bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacodynamic Modelling of Biomarker Data in Oncology
Authors: Jackson Robert C.
Published: February 2012

The development of pharmacodynamic (PD) biomarkers in oncology has implications for design of clinical protocols from preclinical data and for predicting clinical outcomes from early clinical data. Two classes of biomarkers have received particular attention. Phosphoproteins in biopsy samples are markers of inhibition of signalling pathways, target sites for many novel agents. Biomarkers of apoptosis in plasma can measure tumour cell killing by drugs in phase I clinical trials. The predictive power of PD biomarkers is enhanced by data modelling. With pharmacokinetic models, PD models form PK/PD models that predict the time course both of drug concentration and drug effects. If biomarkers of drug toxicity are also measured, the models can predict drug selectivity as well as efficacy. PK/PD models, in conjunction with disease models, make possible virtual clinical trials, in which multiple trial designs are assessed in silico, so the optimal trial design can be selected for experimental evaluation.
Distribuição espacial dos idosos no município de Botucatu segundo o grau de atividade física em atividades de recreação e lazer
Authors: Yamaguti Fabia Tetsue Bicalho , Ruiz Tania , Barrozo Ligia Vizeu , Corrente José Eduardo
Published: February 2012

Introdução: À medida que a população envelhece, cresce a preocupação com a manutenção da sua qualidade de vida e capacidade funcional, que estão associadas ao grau de atividade física mantida. O uso de técnicas de geoprocessamento possibilita a análise espacial de dados de saúde, relacionando-os às características da população estudada, o que permite a o direcionamento de ações a grupos de risco específicos. Objetivo: Estudar a distribuição espacial da população de sessenta anos e mais do município de Botucatu segundo seu grau de atividade física. Métodos: Foi realizada uma amostragem sistemática populacional por famílias. Dessas que possuíam idosos, foram sorteados 365 correspondente a uma prevalência de 50% com uma margem de erro de 5% e confiança de 95%. A esses idosos, foi aplicado vários intrumentos para avaliarqualidade e estilo de vida, dentre eles o International Physical Activities Questionaire (IPAQ). Utilizando o domínio de atividades físicas, esporte, recreação, lazer esses idosos foram classificados como muito ativo, ativo, irregularmente ativo e sedentário,como proposto por Matsudo (2001).Para avaliar a distribuição espacial dos idosos segundo o grau de atividade física de lazer, utilizou-se o indice de Moran. As abálises foram feitas através do programa GeoDa. Resultados: Observou-se que o grau de atividade física é baixo e que existe associação entre os locais de oferta para a prática de esportes, topografia e o grau de atividade física. Não foi observada relação entre o grau de atividade física e o sexo ou a idade dos entrevistados. Conclusão: Aumento e melhor distribuição da estrutura para a prática de atividade física ajudaria a melhorar a atividade desta faixa etária e, portanto, sua qualidade de vida.
Maternagem: estratégia de prevenção em saúde para formação de sujeitos saudáveis
Authors: Buccini Gabriela dos Santos , Tulha Marina Lucia Pereira de Almeida
Published: February 2012

Após o primeiro ano de experiência do Núcleo de Apoio à Saúde da Família (NASF), realizou-se uma análise das principais demandas ou sintomas. Na população infantil, observaram-se dificuldades relacionadas à linguagem, aprendizagem, comportamento e vinculação. Na população adulta, foram encontradas dificuldades relacionadas à autonomia no processo saúde/doença, corpo e resolução de conflitos. Com base nas diretrizes da Atenção Básica, elaborou-se uma intervenção para lidar com as queixas provenientes dos vínculos frágeis que constituem as relações parentais, acarretando consequências para o desenvolvimento ou formação dos sujeitos. Para tanto, criou-se o grupo de Maternagem, que se trata da atividade de cuidar que propicia à criança atenção necessária e suporte emocional para um desenvolvimento neuropsicomotor saudável. Trata-se de um grupo terapêutico-educativo. Em relação às mães, observou-se mudança no posicionamento em relação à educação e colocação de limites, elaboração de conflitos familiares, reflexão sobre sua relação com seus pais, aprimoramento da escuta e vinculação. Nos bebês, observou-se melhora na vinculação, na aceitação do toque materno e nos limites, maior tranquilidade e aprimoramento das habilidades neuropsicomotoras. O desafio é tratar de maternagem com sujeitos que foram pouco maternados, portanto, vulneráveis, pouco autônomos, com dificuldade de estabelecer relações pautadas na confiança/segurança. Em muitos momentos, as mães é que são maternadas, ressignificando seus primeiros vínculos, recuperando o brincar e a fantasia. Acredita-se que a mudança do sujeito-mãe possa ocorrer por meio da transformação da relação mãe-bebê, o que será determinante na formação do sujeito-bebê e possibilitará a ressignificação das relações familiares, produzindo saúde.
Permeability mapping in naturally heterogeneous sandstone cores by magnetization prepared centric‐scan sprite
Authors: Romanenko Konstantin , Balcom Bruce J.
Published: February 2012

A time‐efficient MRI method suitable for quantitative two‐dimensional (2‐D) mapping of permeability in sedimentary rock cores, and granular media samples is discussed. The images of porosity and mean axial velocity in the plane transverse to the average flow direction are essential to determine 2‐D distribution of permeability in a core sample. The 2‐D permeability mapping is particularly useful for discrimination of bedding and lamination layers, fractures and fault facies that occur in sedimentary rocks. The proposed method combines the 13‐interval APGSTE scheme and centric‐scan SPRITE. The APGSTE scheme is known to substantially reduce gradient‐related errors in diffusion measurements. The SPRITE method provides quantitative information on fluid content within the core samples. The experiment time is critically reduced when only a few samples near theq‐space origin are collected. The APGSTE‐SPRITE method is illustrated through mapping of 2‐D permeability and 3‐D velocity field in naturally heterogeneous sandstone cores. © 2012 American Institute of Chemical Engineers AIChE J, 2012
Chemistry of Anthracene–Acetylene Oligomers XX: Synthesis, Structures, and Self‐Association of Anthracene–Anthraquinone Cyclic Compounds with Ethynylene Linkers
Authors: Iwanaga Tetsuo , Miyamoto Kazuaki , Tahara Kazukuni , Inukai Koji , Okuhata Satoshi , Tobe Yoshito , Toyota Shinji
Published: February 2012

We have synthesized anthracene–acetylene oligomers, which contained one 10‐substituted anthracene unit and one anthraquinone unit, by cyclization with Sonogashira coupling. X‐ray analysis revealed an almost‐planar framework and significant out‐of‐plane deformation around the inner carbonyl moiety because of steric hindrance. These compounds underwent self‐association in solution and their association constants for monomer–dimer exchange were determined by variable‐concentration 1H NMR measurements in CDCl3: 8 mol−1 L (10‐substituent: isopropyl), <5 mol−1 L (methoxy), and 19 mol−1 L (octyloxy). These results were discussed on the basis of spectroscopic and molecular‐orbital analysis. A linear molecular assembly of the octyloxy compound at a liquid/graphite interface was observed by STM measurements.
Open‐field arena boundary is a primary object of exploration for Drosophila
Authors: Soibam Benjamin , Mann Monica , Liu Lingzhi , Tran Jessica , Lobaina Milena , Kang Yuan Yuan , Gunaratne Gemunu H. , Pletcher Scott , Roman Gregg
Published: February 2012

Drosophila adults, when placed into a novel open‐field arena, initially exhibit an elevated level of activity followed by a reduced stable level of spontaneous activity and spend a majority of time near the arena edge, executing motions along the walls. In order to determine the environmental features that are responsible for the initial high activity and wall‐following behavior exhibited during exploration, we examined wild‐type and visually impaired mutants in arenas with different vertical surfaces. These experiments support the conclusion that the wall‐following behavior of Drosophila is best characterized by a preference for the arena boundary, and not thigmotaxis or centrophobicity. In circular arenas, Drosophila mostly move in trajectories with low turn angles. Since the boundary preference could derive from highly linear trajectories, we further developed a simulation program to model the effects of turn angle on the boundary preference. In an hourglass‐shaped arena with convex‐angled walls that forced a straight versus wall‐following choice, the simulation with constrained turn angles predicted general movement across a central gap, whereas Drosophila tend to follow the wall. Hence, low turn angled movement does not drive the boundary preference. Lastly, visually impaired Drosophila demonstrate a defect in attenuation of the elevated initial activity. Interestingly, the visually impaired w1118 activity decay defect can be rescued by increasing the contrast of the arena's edge, suggesting that the activity decay relies on visual detection of the boundary. The arena boundary is, therefore, a primary object of exploration for Drosophila.
New Isoprenylated Flavones and Stilbene Derivative from Artocarpus hypargyreus
Authors: Yu Mei‐Hua , Zhao Ting , Yan Gui‐Rui , Yang Hong‐Xun , Wang He‐Yao , Hou Ai‐Jun
Published: February 2012

Three new isoprenylated flavones, hypargyflavones A–C (1–3, resp.), and one novel stilbene derivative, hypargystilbene A (4), together with seven known compounds, 5–11, were isolated from the stems of Artocarpus hypargyreus Hance. The structures were elucidated by spectroscopic methods. Hypargyflavone A (1), cudraflavone C (8), brosimone I (10), and norartocarpin (11) showed inhibitory effects on pancreatic lipase.
The Influence of Certain Taxonomic and Environmental Parameters on Biomass Production and Triterpenoid Content in the Leaves of Centella asiatica (L.) Urb. from Madagascar
Authors: Rahajanirina Voninavoko , Rakotondralambo Raoseta Soaharin'ny Ony , Roger Edmond , Razafindrazaka Harena , Pirotais Sarah , Boucher Marie , Danthu Pascal
Published: February 2012

Centella asiatica (Apiaceae family; Talapetraka in Malagasy) is a tropical and subtropical plant with leaves containing glycotriterpenoids (asiaticosides) used in traditional and modern medicine. C. asiatica is collected exclusively in natural stands. It is Madagascar's second most important indigenous plant export. The objective in this study is to provide data which will make it possible to optimize the harvest and thus effectively develop this resource. Two foliar morphotypes were identified: morphotype A with small reniform leaves (leaf area ca. 4.5 cm2), found in the east of Madagascar, and morphotype B with large round leaves (up to 7.5 cm2) found in the west, with sympatric zones in the central part of the island. Morphotype A produces a higher biomass, and is twice as rich in asiaticosides as morphotype B. Significant variations in biomass yield and asiaticoside content are observed depending on the date of collection: higher during the rainy season (December to April) and lower during the dry season (June to August). Inter‐annual variations are also observed. Populations located at around 800–1400 m altitude on the eastern side of Madagascar, in a sub‐humid climate, appeared to be more productive. These results provide more precise information to the economic sector, which confirms the empirical choices made by collectors. They represent the first elements towards sustainable management of the resource, and maybe even domestication.
A Novel Phytotoxic Nonenolide from Phomopsis sp. HCCB03520
Authors: Yang Zhijun , Ge Mei , Yin Yu , Chen Yi , Luo Minyu , Chen Daijie
Published: February 2012

A novel phytotoxic nonenolide, (6S,7R,9R)‐6,7‐dihydroxy‐9‐propylnon‐4‐eno‐9‐lactone (1), was isolated from solid cultures of the endophytic fungus Phomopsis sp. HCCB03520, together with three known compounds, cytochalasin H (2), cytochalasin N (3), and epoxycytochalasin H (4). The structures of these compounds were elucidated through spectroscopic analysis, and the absolute configurations were determined by CD spectroscopy. Phytotoxic activities of compounds 1–4 were also investigated. Compound 1 showed phytotoxic activity on germination and radicle growth of Medicago sativa, Trifolium hybridum, and Buchloe dactyloides.
Phytochemical and Biological Studies of Ochna Species
Authors: Bandi Anil Kumar Reddy , Lee Dong‐Ung , Tih Raphaël Ghogomu , Gunasekar Duvvuru , Bodo Bernard
Published: February 2012

The genus Ochna L. (Gr, Ochne; wild pear), belonging to the Ochnaceae family, includes ca. 85 species of evergreen trees, shrubs, and shrublets, distributed in tropical Asia, Africa, and America. Several members of this genus have long been used in folk medicine for treatment of various ailments, such as asthma, dysentery, epilepsy, gastric disorders, menstrual complaints, lumbago, ulcers, as an abortifacient, and as antidote against snake bites. Up to now, ca. 111 constituents, viz. flavonoids (including bi‐, tri‐, and pentaflavonoids), anthranoids, triterpenes, steroids, fatty acids, and a few others have been identified in the genus. Crude extracts and isolated compounds have been found to exhibit analgesic, anti‐HIV‐1, anti‐inflammatory, antimalarial, antimicrobial, and cytotoxic activities, lending support to the rationale behind several of its traditional uses. The present review compiles the informations concerning the traditional uses, phytochemistry, and biological activities of Ochna.
Seasonal Variations of Phenolic Compounds and Biological Properties in Sage (Salvia officinalis L.)
Authors: Generalić Ivana , Skroza Danijela , Šurjak Jana , Možina Sonja Smole , Ljubenkov Ivica , Katalinić Ana , Šimat Vida , Katalinić Višnja
Published: February 2012

The aim was to investigate the phenolic content, antioxidant capacity, and antibacterial activity of Dalmatian sage (Salvia officinalis L.) leaves collected during different vegetation periods. Separation and quantification of the individual phenols were performed by reversed‐phase (RP)‐HPLC coupled with a PDA (photodiode array) detector and using an internal standard, while the contents of total phenols, flavonoids, flavones, and flavonols were determined spectrophotometrically. The antioxidant properties of the sage leaf extracts were evaluated using five different antioxidant assays (FRAP, DPPH, ABTS, BriggsRauscher reaction, and β‐carotene bleaching). The antimicrobial activity of the extracts was tested against two Gram‐positive (Bacillus cereus and Staphylococcus aureus) and two Gram‐negative (Salmonella Infantis and Escherichia coli) bacterial reference strains. All extracts were extremely rich in phenolic compounds, and provided good antioxidant and antibacterial properties, but the phenophase in which the leaves were collected affected the phenolic composition of the sage extracts and consequently their biological activity. The May Extract, the richest in total flavonoids, showed the best antioxidant properties and the highest antimicrobial activity. Thus, collection of the plants during May seems the best choice for further use of them in the pharmaceutical and food industry.
Putative Binding Sites, and Pathways to Them, for Amidine and Guanidine Current Inhibitors on Acid‐Sensing Ion Channels (ASIC). A Theoretical Approach with hASIC1a Homology Model
Authors: Pietra Francesco
Published: February 2012

Central inhibition of the acid‐sensing hASIC1a channel, acting upstream of the opiate system, might serve to treat any type of pain, avoiding the unwanted addiction problems of the opioid drugs. To this end, inhibition of hASIC1a channel by PcTx1, a peptide from the Trinidad chevron tarantula, is under development. New inhibitors of the hASIC1a channel are also being sought, in the hope of further modulating the activity, from which antiplasmodial amidine and guanidine phenyl drugs have emerged as promising candidates. However, how such current inhibition takes place remains obscure from the molecular point of view, hindering any further progress in developing drugs. Therefore, the nature of the binding sites, and how they are reached by the amidine‐guanidine drugs, was investigated here via automated docking and molecular dynamics with hASIC1a homology models. This study has revealed that this ion channel is rich in binding sites, and that flexible drugs, such as nafamostat, may penetrate it in a snake‐like elongated conformation. Then, crawling like a snake through temporary holes in the protein, nafamostat either simply flips, or changes to a high‐energy folded conformation to become adapted to the shape of the binding site.
ChemInform Abstract: Variation of Oxygen Content in Selected Potassium Fluorido‐oxido‐tantalate Phases.
Authors: Boca Miroslav , Moncol Jan , Netriova Zuzana , Velic Dusan , Jerigova Monika , Nunney Tim S. , Baily Christopher J. , Kubikova Blanka , Simko Frantisek , Janderka Pavel
Published: February 2012

K3[TaO4]·K3 [TaF4O2] is characterized by powder and single crystal XRD, XPS, and SIMS.
ChemInform Abstract: Efficient Synthesis of Plate‐Like Crystalline Hydrated Tungsten Trioxide Thin Films with Highly Improved Electrochromic Performance.
Authors: Jiao Zhihui , Wang Xiu , Wang Jinmin , Ke Lin , Demir Hilmi Volkan , Koh Tien Wei , Sun Xiao Wei
Published: February 2012

Nanostructured 3WO3·H2O films are prepared by hydrothermal treatment of a crystal‐seed‐coated F‐doped tin oxide glass substrate and an aqueous Na2WO4 solution containing HCl, H2O2, and Na2SO4 as a capping agent (autoclave, 180 °C, 2 h).
ChemInform Abstract: A Perovskite Oxide Optimized for Oxygen Evolution Catalysis from Molecular Orbital Principles.
Authors: Suntivich Jin , May Kevin J. , Gasteiger Hubert A. , Goodenough John B. , Shao‐Horn Yang
Published: February 2012

Ba0.5Sr0.5Co0.8Fe0.2 O3‐δ catalyzes the oxygen evolution reaction with intrinsic activity that is at least one order of magnitude higher than that of the state‐of‐the‐art IrO2 catalyst in alkaline media.
ChemInform Abstract: Solvothermal Synthesis of a Bimetallic Thiometallate Containing Germanium in Two Oxidation States.
Authors: Powell Anthony V. , Mackay Rosalyn
Published: February 2012

Single crystals of the new compound [Ge(en)3][GeSb2S6] are prepared by solvothermal reaction of GeO2, Sb2S3, and sulfur in ethylenediamine (autoclave, 463 K, 6 d, 80% yield).
ChemInform Abstract: New Quaternary Sulfides in the AE‐RE‐Sn‐S System (AE = Alkaline‐Earth, RE = Rare Earth).
Authors: Zeng Hui‐Yi , Zhao Zhong‐Yan , Guo Sheng‐Ping , Zheng Fa‐Kun , Guo Guo‐Cong , Huang Jin‐Shun
Published: February 2012

The new compounds Sr2Y2.67Sn3S12, Ca3La2Sn3S12, and Ca3Er2Sn3s12 are prepared from appropriate mixtures of CaS, SrS, La2S3, Er2S3, SnS2, Sn, S, La, or Y using KBr as fluxing agent (silica ampules, 950—1000 °C, 100—316 h).
ChemInform Abstract: New Antimonato Polyoxovanadates Based on the [V14IVSb8IIIO42 (H2O)]4‐ Cluster Type.
Authors: Antonova Elena , Wutkowski Adam , Naether Christian , Bensch Wolfgang
Published: February 2012

The new compounds (III) and (IV) are characterized by single crystal XRD and IR and Raman spectroscopy.
ChemInform Abstract: Spontaneous Self‐Assembly of a Giant Spherical Metal‐Oxide Keplerate: Addition of One Building Block Induces “Immediate” Formation of the Complementary One from a Constitutional Dynamic Library.
Authors: Schaeffer Christian , Todea Ana Maria , Gouzerh Pierre , Mueller Achim
Published: February 2012

(NH4)42 [MoVI72MoV60O372 (OAc)30(H2O)72] ·300H2O·10NH4OAc (I) is synthesized by addition of the oxalato complex (NH4)2 [Mo2O4(C2O4)2 (H2O)2]·3H2O to an aqueous solution of (NH4)6Mo7O24, AcOH, and NH4OH at pH 4 (4 h, 16% yield).
ChemInform Abstract: Synthesis, Structures and Properties of New Hybrid Solids Containing Ruthenium Complexes and Polyoxometalates.
Authors: Yan Bangbo , Hodsdon Samantha A. , Li Yan‐Fen , Carmichael Christopher N. , Cao Yan , Pan Wei‐Ping
Published: February 2012

Compounds (IV) and (VI) (yields are given in gram) are characterized by powder and single crystal XRD and FTIR, UV/VIS, and luminescence spectroscopy.
ChemInform Abstract: Crystal Growth, Structure, and Physical Properties of Ln2PdGa12 (Ln: La, Pr, Nd, and Sm).
Authors: Kangas Michael J. , Drake Brenton L. , Haldolaarachchige Neel , Young D. P. , Chan Julia Y.
Published: February 2012

Single crystals of the title compounds are prepared by reaction of the elements using excess Ga as flux (alumina crucibles, 1150 °C, 7 h).
ChemInform Abstract: Experimental and Theoretical Investigation of the Scope of Enantioselective Ketone Allylations Employing Nakamura′s Allylzinc—Bisoxazoline Reagent.
Authors: Johnson A. George , Loertscher Brad M. , Moeck Adam R. , Matthews Sam S. , Ess Daniel H. , Castle Steven L.
Published: February 2012

The allylation of asymmetric ketones generally proceeds with good yields and low to moderate enantiomeric excess.
ChemInform Abstract: Catalytic Asymmetric Activation of a C(sp3)—H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α‐Alkyl α‐Amino Acids and C1‐Alkylated Tetrahydroisoquinoline Derivatives.
Authors: Zhang Gen , Zhang Yaohu , Wang Rui
Published: February 2012

The DDQ‐mediated cross‐dehydrogenative coupling of a variety of oxocyclopentanecarboxylates or analogues with glycine esters is efficiently catalyzed by Cu(II)/chiral bisoxazoline.
ChemInform Abstract: New Chiral Sulfonamide Ligands Derived from L‐Proline for Catalytic Enantioselective Cyclopropanation.
Authors: Shi Xiao‐hua , Li Cun , Jin Zhao , Zhou Cai‐rong , Jiang Deng‐gao
Published: February 2012

Chiral ligands derived from L‐proline are found to catalyze the Simmons—Smith cyclopropanation of cinnamyl alcohol (I).
ChemInform Abstract: Organocatalytic Enantioselective [3 + 2] Cycloaddition Using Stable Azomethine Ylides.
Authors: Fernandez Naiara , Carrillo Luisa , Vicario Jose L. , Badia Dolores , Reyes Efraim
Published: February 2012

The catalytic enantioselective [3 + 2] cycloaddition between enals (II) and stable azomethine ylides (I) and (IV) is described.
ChemInform Abstract: One‐Pot Oxidation of Alanine and Its Ethyl Ester with a Mild Oxidant 4′‐Methylazobenzene‐2‐sulfenyl Bromide.
Authors: Barman Pranjit , Bhattacharjee Saibal Kanti , Bhattacharjee Tirtha
Published: February 2012

One pot oxidation of alanine (I) and its ethyl ester (V) with sulfenyl bromide (II) followed by hydrolysis leads ethanal (IV) and pyruvic acid (VII), resp., which are isolated as 2,4‐dinitrophenylhydrazones (no yields given).
ChemInform Abstract: Novel Synthetic Methodologies. Part 228. Copper‐Catalyzed Coupling of Imidazoles and Pyrazoles with 1,1‐Dibromo‐1‐alkenes: A Distinct Approach for Direct N‐Alkylation of Heteroarenes.
Authors: Das Biswanath , Salvanna N. , Reddy Gandolla Chinna , Balasubramanyam Penagaluri
Published: February 2012

Under optimized conditions, the reactions of imidazoles or pyrazoles with dibromoalkenes afford the corresponding N‐alkynylated products.
ChemInform Abstract: Cobalt‐Catalyzed Reductive Allylation of Alkyl Halides with Allylic Acetates or Carbonates.
Authors: Qian Xin , Auffrant Audrey , Felouat Abdellah , Gosmini Corinne
Published: February 2012

Under optimized conditions, a variety of allylic acetates and carbonates undergo the title reaction with primary, secondary, and tertiary alkyl halides to give predominantly the linear products (with a minimal proportion of 78%).
ChemInform Abstract: Catalytic Monosilylation of 1,2‐Diols
Authors: Takeichi Tsubasa , Kuriyama Masami , Onomura Osamu
Published: February 2012

using dimethyltin dichloride as the catalyst
ChemInform Abstract: An Expedient, Fast and Competent Synthesis of Organic Dithiocarbamates over Nanocrystalline MgO in Water at Room Temperature.
Authors: Karmakar Bikash , Banerji Julie
Published: February 2012

MgO nanoparticles efficiently catalyze the three component reaction of amines, olefins, and carbon disulfide to produce dithiocarbamates (IV) (16 examples).
ChemInform Abstract: Solvent‐Free and Efficient Synthesis of Highly Functionalized Cyclohexa‐1,3‐diene Derivatives via a Novel One‐Pot Three‐Component Reaction.
Authors: Alizadeh Abdolali , Rezvanian Atieh , Mokhtari Javad
Published: February 2012

The procedure allows readily access to the title compounds as important substructures of biologically active products.
ChemInform Abstract: Carbene Adduct of Cyclopalladated Ferrocenylimine Catalyzed α‐Arylation of Ketones with Aryl Chlorides or Bromides.
Authors: Zhang Jinli , Yang Xueqian , Cui Xiuling , Wu Yangjie
Published: February 2012

A variety of aryl chlorides and bromides, including unactivated and sterically hindered halides, successfully undergoes α‐arylation of aryl alkyl ketones as well as cyclic ketones in the presence of a novel ferrocenylimine—Pd(II)—NHC ligand.
ChemInform Abstract: Short Synthesis of Ethyl 3‐(3‐Aminophenyl)propanoate (V).
Authors: Nagel Ulrike , Radau Gregor , Link; Andreas Link; Andreas
Published: February 2012

The title compound (V) is efficiently obtained using a tandem Knoevenagel condensation/alkylidene reduction of 3‐nitrobenzaldehyde with Meldrum′s acid in the presence of triethylammonium formate followed by reduction of the intermediate 3‐(3‐nitrophenyl)propanoic acid by stannous chloride.
ChemInform Abstract: Oxidative C—H Homodimerization of Phenylacetamides.
Authors: Pintori Didier G. , Greaney Michael F.
Published: February 2012

The reaction applies catalytic amounts of Pd(OAc)2 and Cu(OTf)2 under oxygen atmosphere to afford symmetrical 2,2‐disubstituted biaryls that display a wide range of amide functionality and tolerates ortho‐, meta‐ and para substitution at the biphenyl rings.
ChemInform Abstract: Mild Synthesis of N′‐Aryl‐N,N‐dimethylformamidinium Chloride by Vilsmeier—Haack Reagent.
Authors: Meng Ge , Sha Yao Wu , Zhang Rui , Bai Nan
Published: February 2012

Good to excellent yields of the title compounds, suitable synthons for biologically important heterocyclic systems, are obtained for p‐substituted anilines, whereas lower yields are achieved with m‐ and o‐substituted substrates.
ChemInform Abstract: Stereoselective Synthesis of Polyfunctional Tetrasubstituted Alkenyl Sulfides via a Carbocupration of Alkynyl Sulfides with Aryl and Benzylic Diorganozincs.
Authors: Dunst Cora , Metzger Albrecht , Zaburdaeva Elena A. , Knochel Paul
Published: February 2012

The process results in an (E)‐selective synthesis of tri‐ and tetrasubstituted alkenyl sulfides.
ChemInform Abstract: Heterobimetallic Dianionic Guanidinate Complexes of Lanthanide and Lithium: Highly Efficient Precatalysts for Catalytic Addition of Amines to Carbodiimides to Synthesize Guanidines.
Authors: Zhang Xingmin , Wang Chuanyong , Qian Cunwei , Han Fubin , Xu Fan , Shen Qi
Published: February 2012

The addition of a wide variety of aromatic and aliphatic primary (III) and secondary amines (IV) towards carbodiimides, e.g. (II), is efficiently catalyzed by a heterobimetallic La/Li guanidinate complex.
ChemInform Abstract: An Efficient Synthesis of N‐Substituted‐3‐aryl‐3‐ (2‐hydroxy‐4,4‐dimethyl‐6‐oxocyclohex‐1‐enyl)propanamides by Four‐Component Reaction in Aqueous Medium.
Authors: Dou Guolan , Zhong Xiaoxing , Wang Deming , Shi Daqing
Published: February 2012

The reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Synthesis of 5‐Substituted 2,3‐Dihydrobenzofurans in a One‐Pot Oxidation/Cyclization Reaction.
Authors: Baragona Fabien , Lomberget Thierry , Duchamp Christian , Henriques Natali , Piccolo Eugenio Lo , Diana Patrizia , Montalbano Alessandra , Barret Roland
Published: February 2012

The oxidation of N‐protected p‐aminophenol derivatives to quinone imides is combined with cycloaddition towards azadiene (II) in a one‐pot reaction to give dihydrobenzofuran derivatives in moderate to good yields.
ChemInform Abstract: Non‐Steroidal Dissociated Glucocorticoid Agonists: Indoles as A‐Ring Mimetics and Function‐Regulating Pharmacophores.
Authors: Betageri Raj , et al. et al.
Published: February 2012

SAR analysis of non‐steroidal glycocorticoid mimetics lead to the discovery of new agonist (I), which shows high progesterone receptor and mineralocorticoid receptor selectivity, potent agonist activity, and reduced transactivation activity in the MMTV (mouse mammary tumor virus) and aromatase assays.
ChemInform Abstract: PdII/IV‐Catalyzed Oxidative Cyclization of 1,6‐Enynes Derived by Ugi‐4‐Component Reaction.
Authors: Welsch Sebastian J. , Umkehrer Michael , Ross Guenther , Kolb Juergen , Burdack Christoph , Wessjohann Ludger A.
Published: February 2012

Various functionalities are tested in the process which affords the ring system (VI) with 3 points of diversity.
ChemInform Abstract: Design, Synthesis, and Antiproliferative Activity of 3,4‐Diarylpyrazole‐1‐carboxamide Derivatives Against Melanoma Cell Line.
Authors: El‐Gamal Mohammed I. , Choi Hong Seok , Cho Hae‐Guk , Hong Jun Hee , Yoo Kyung Ho , Oh Chang‐Hyun
Published: February 2012

The title compounds (III) and (IV) are screened for their antiproliferative activity against the A375 human melanoma cell line.
ChemInform Abstract: Synthesis and Reactivity of 5‐Methylenehydantoins.
Authors: Fraile Jose M. , Lafuente Gustavo , Mayoral Jose A. , Pallares Antonio
Published: February 2012

Methylenehydantoins (V)/(VI), (IX) or (XXVII) are prepared on different ways.
ChemInform Abstract: Synthesis of Mono‐ and Bis‐N‐heterocyclic Carbene Copper(I) Complexes via Decarboxylative Generation of Carbenes.
Authors: Le Gall Tatiana , Baltatu Sandra , Collins Shawn K.
Published: February 2012

Zwitterionic carboxylate derivatives (III) and (VII) are easily prepared from the corresponding imidazolium or imidazolinium tetrafluoroborates.
ChemInform Abstract: Discovery, Synthesis and SAR Analysis of Novel Selective Small Molecule S1P4‐R Agonists Based on a (2Z,5Z)‐5‐((Pyrrol‐3‐yl)methylene)‐3‐alkyl‐2‐ (alkylimino)thiazolidin‐4‐one Chemotype.
Authors: Roberts Edward , et al. et al.
Published: February 2012

The promising lead molecule (CYM50308) (I), a full spectrum selective S1P4‐R agonist, displays low nanomolecular S1P4 agonist activity and exquisite selectivity over the other S1P1‐3.5‐Rs family members.
ChemInform Abstract: One‐Pot Click Synthesis of 1N‐Alkyl‐4‐aryl‐1,2,3‐triazoles from Protected Arylalkynes and Alkyl Bromides.
Authors: Ladouceur Sebastien , Soliman Ahmed M. , Zysman‐Colman Eli
Published: February 2012

A convenient protocol allows the synthesis of the target compounds via in situ alkyl azide formation, alkyne deprotection and subsequent copper‐catalyzed cycloaddition.
ChemInform Abstract: Enantioselective Palladium‐Catalyzed Allylic Substitution of Sodium Benzotriazolide.
Authors: Liu Wei , Zhang Dazhi , Zheng Shengcai , Yue Yinshuang , Liu Dongge , Zhao Xiaoming
Published: February 2012

Asymmetric allylic allylation of sodium benzotriazolide (II) is efficiently catalyzed by a Pd—PHOX catalyst to afford a mixture of regioisomers (III) and (IV).
ChemInform Abstract: Synthesis of (Tetrahydrofuranyl)methyl‐1,2,3‐triazoles Through Alkyne‐Azide Cycloaddition Catalyzed by a Dithioic Acid Copper(I) Complex.
Authors: Velasco Bayardo E. , Fuentes Aydee , Gonzalez Carlos , Corona David , Garcia‐Orozco Ivan , Cuevas‐Yanez Erick
Published: February 2012

A novel kind of dithioic acid copper(I) complex is employed as catalyst in an azide‐alkyne cycloaddition (CuAAC) reaction leading regioselectively to triazoles (III) and (VIII).
ChemInform Abstract: A Multicomponent Reaction Between α‐Substituted Acroleins, Nitroalkanes and Paraformaldehyde: Efficient Construction of Nitro δ‐Lactol.
Authors: Xiong Guoxi , Wei Mohui , Zhou Yirong , Li Yungui , Zhang Fanglin , Gong Yuefa
Published: February 2012

A three‐component reaction followed by deoxygenation or oxidation offers an interesting synthesis of nitropyrans (IV) or analogous pyranones (IX).
ChemInform Abstract: Green Synthesis of Chromen‐2‐one Derivatives Catalyzed by L‐Proline.
Authors: Shi Chunling , Shi Da‐Qing
Published: February 2012

A mild and efficient synthesis of the title compounds (III) via reaction of 4‐hydroxy‐6‐methyl‐pyran‐one with various substituted 2‐hydroxybenzaldehydes in water is described.
ChemInform Abstract: Aldol Condensation and Michael Addition of 4,4‐Diemthylcyclohexane‐1,3‐dione and Aromatic Aldehydes. Unconventional Substituent Effects.
Authors: Kaya Muharrem
Published: February 2012

Electronic and steric effects on the aromatic aldehydes influence the regiochemistry of the title reaction.
ChemInform Abstract: Synthesis and Biological Evaluation of New 3‐(6‐Hydroxyindol‐2‐yl)‐5‐(phenyl) Pyridine or Pyrazine V‐Shaped Molecules as Kinase Inhibitors and Cytotoxic Agents.
Authors: Merour Jean‐Yves , et al. et al.
Published: February 2012

The new V‐shaped library which is represented by the general indole structure (VII) is obtained by using palladium catalyzed cross‐coupling reactions (Stille, Suzuki and Buchwald), mostly performed under microwave irradiation.
ChemInform Abstract: A Versatile Synthesis of Substituted Isoquinolines.
Authors: Si Chong , Myers Andrew G.
Published: February 2012

Highly substituted isoquinolines of extraordinary structural versatility are prepared starting from N‐tert‐butylimines of o‐tolualdehydes.
ChemInform Abstract: Mechanistic Studies on a New Catalyst System (CuI—NaHSO4·SiO2) Leading to the One‐Pot Synthesis of Imidazo[1,2‐a]pyridines from Reactions of 2‐Aminopyridines, Aldehydes, and Terminal Alkynes.
Authors: Mishra Sarita , Ghosh Rina
Published: February 2012

The procedure is highly suitable for the preparation of the clinically potent skeleton (28 examples).
ChemInform Abstract: Suzuki—Miyaura and Negishi Approaches to a Series of Forensically Relevant Pyridines and Pyrimidines.
Authors: Blachut Dariusz , Szawkalo Joanna , Czarnocki Zbigniew
Published: February 2012

A variety of 5‐arylpyrimidines (III) (13 examples) is prepared by Suzuki—Miyaura coupling.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel (Thio)Urea Derivatives as Potential Antitumor Agents.
Authors: Jin Chuanfei , Liang Yong‐Ju , He Hongwu , Fu Liwu
Published: February 2012

Compound (Ve) displays more potent cytotoxic activities against KB, MGC‐803 and MCF‐7 tumor cell lines than reference 5‐fluorouracil.
ChemInform Abstract: Improvement of the Synthesis and Pharmacokinetic Properties of Chromenotriazolopyrimidine MDM2‐p53 Protein‐Protein Inhibitors.
Authors: Beck Hilary P. , et al. et al.
Published: February 2012

A more robust and scalable synthetic route to chromenotriazolopyrimidine core (VI) is developed.
ChemInform Abstract: Palladium‐Catalyzed Direct 5‐Arylation of 1,3‐Dimethyluracil with Aryl Bromides: An Electrophilic Metalation—Deprotonation with Electrophilic Arylpalladium Intermediate.
Authors: Kim Ko Hoon , Lee Hyun Seung , Kim Jae Nyoung
Published: February 2012

The 6‐aryl derivatives (IV) are generated via a Heck‐type mechanism as minor products.
ChemInform Abstract: An Efficient Approach for the One‐Pot Synthesis of Ethyl 4‐Oxo‐4H‐benzo[d][1,3]oxazine‐2‐carboxylates.
Authors: Nikpour Farzad , Sharafi‐Kolkeshvandi Mahnaz , Bahmani Asrin
Published: February 2012

A simple and convenient access to title compounds (III) is described.
ChemInform Abstract: A Convenient and General Palladium‐Catalyzed Carbonylative Coupling for the Synthesis of 2‐Arylbenzoxazinones.
Authors: Wu Xiao‐Feng , Schranck Johannes , Neumann Helfried , Beller Matthias
Published: February 2012

A new Pd‐catalyzed double carbonylation of o‐aminoaryl bromides in the presence of aryl bromides is presented to furnish a diversity of benzoxazinones, e.g. (IV) and (IX), in good yields.
ChemInform Abstract: A New Synthetic Approach to Pentacyclic Ring, 6,7,14,15‐Tetrahydro[1,5]diazocino[1,2‐a:6,5‐a′]‐8‐dihydrodiindole.
Authors: Sripha Kittisak , Zlotos Darius Paul , Holzgrabe Ulrike , Ruchirawat Somsak
Published: February 2012

The construction of the new pentacyclic title ring system (VII) is presented.
ChemInform Abstract: Orally Bioavailable Imidazoazepanes as Calcitonin Gene‐Related Peptide (CGRP) Receptor Antagonists: Discovery of MK‐2918.
Authors: Paone Daniel V. , et al. et al.
Published: February 2012

Fused heterocyclic derivatives of telcagepant are explored with the aim to achieve a lower projected clinical dose.
ChemInform Abstract: Dialkylaluminum Hydride‐Promoted Cyclodimerization of Silylated 1,3‐Enynes via Skeletal Rearrangement.
Authors: Kinoshita Hidenori , Ishikawa Tomoyuki , Miura Katsukiyo
Published: February 2012

Symmetrical tetrasubstituted benzenes (II) and (IV) are prepared as single regioisomers by a novel cyclodimerization reaction of silylated 1,3‐enynes (I) and (III) in the presence of a dialkylaluminum hydride.
ChemInform Abstract: An Efficient One‐Pot Synthesis of Trialkyl 2‐(Dialkoxyphosphoryl)ethene‐1,1,2‐tricarboxylates
Authors: Yavari Issa , Sanaeishoar Tayebeh , Azad Leila , Arab‐Salmanabadi Samira
Published: February 2012

via reaction of activated acetylenes, trialkyl phosphites, and alkyl cyanoformates under neutral reaction conditions
ChemInform Abstract: Stereoselective Synthesis of Dialkyl 2‐(Dialkoxyphosphoryl)‐3‐(3,5‐dioxo‐4‐phenyl‐[1,2,4]triazolidin‐1‐yl) Succinates
Authors: Mohebat Razieh , Moghaddam Mahtab Iravani , Motlagh Ramin Askari , Hassanabadi Alireza , Kalami‐Yazdi Masoud
Published: February 2012

via multicomponent reaction of acetylenedicarboxylates (III) with the N‐H acid triazolidine‐dione (I) in the presence of phosphites (II)
ChemInform Abstract: Microwave‐Assisted Solvent‐Free Synthesis of Pseudohalophosphates.
Authors: Shi Enxue , Xiao Junhua , Pei Chengxin , Chen Jisheng
Published: February 2012

An efficient and catalyst‐free procedure for the synthesis of pseudohalophosphates is developed.
ChemInform Abstract: Direct Synthesis of Alkynylstannanes: ZnBr2 Catalyst for the Reaction of Tributyltin Methoxide and Terminal Alkynes.
Authors: Kiyokawa Kensuke , Tachikake Nodoka , Yasuda Makoto , Baba Akio
Published: February 2012

Rather than acting as a Lewis acid, ZnBr2 is transmetalated with Bu3SnOMe to give Zn(OMe)2, which is the key to the catalytic reaction.
ChemInform Abstract: Spicachlorantins G—J, New Lindenane Sesquiterpenoid Dimers from the Roots of Chloranthus spicatus.
Authors: Kim Sang‐Yong , Kashiwada Yoshiki , Kawazoe Kazuyoshi , Murakami Kotaro , Sun Han‐Dong , Li Shun‐Lin , Takaishi Yoshihisa
Published: February 2012

Four new lindenane sesquiterpenoid dimers named spicachlorantins G—J (I)‐(III) are isolated from the roots of Chloranthus spicatus together with seven known compounds.
ChemInform Abstract: Crassocolides N—P, Three Cembranoids from the Formosan Soft Coral Sarcophyton crassocaule.
Authors: Wang Guey‐Horng , Huang Ho‐Cheng , Su Jui‐Hsin , Huang Chiung‐Yao , Hsu Chi‐Hsin , Kuo Yao‐Haur , Sheu Jyh‐Horng
Published: February 2012

The crassocolides N—P (I)—(III) are screened for their cytotoxic activity against KB, HeLa, and Daoy cells.
ChemInform Abstract: A Phosphine‐Mediated Synthesis of 1,4‐Oxazepine‐ and 1,5‐Oxazocine‐Based Sugar Hybrids from Deoxysugar Azides.
Authors: Kurhade Suresh E. , Salunkhe Videsh T. , Siddaiah V. , Bhuniya Debnath , Reddy D. Srinivasa
Published: February 2012

The process allows the preparation of biologically interesting heterocyclic systems of type (III) and (VI).
ChemInform Abstract: Reactions of Arylhydrazones of Dehydro‐L‐ascorbic Acid and of D‐Arabino‐2,3‐diulosono‐1,4‐lactone.
Authors: El‐Sekily M. A. , Mancy S. H.
Published: February 2012

With the aim to produce effective chemotherapeutic agents, pyrazole derivatives (I) ‐ (III) are synthesized from the carbohydrate‐derived arylhydrazones.
ChemInform Abstract: Hydrolysis of Sugars Using Magnetic Silica Nanoparticles with Sulfonic Acid Groups.
Authors: Takagaki Atsushi , Nishimura Masatoshi , Nishimura Shun , Ebitani Kohki
Published: February 2012

A highly active and reusable solid catalyst, which can be recovered by facile magnetic separation, for the title reaction is presented.
ChemInform Abstract: Alkaloids from Chelidonium majus and Their Inhibitory Effects on LPS‐Induced NO Production in RAW264.7 Cells.
Authors: Min Byung Sun , et al. et al.
Published: February 2012

The new alkaloid (Ia), methyl 2′‐(7,8‐dihydrosanguinarine‐8‐yl)acetate, is isolated together with six known alkaloids.
ChemInform Abstract: Synthesis of New Oxabicyclo[3.3.0]octane Nucleoside Analogues with Pyrimidine Bases.
Authors: Tanase Constantin , Cocu Florea G. , Caproiu Miron T. , Draghici Constantin , Neagoe Ionela Victoria , Manda Gina
Published: February 2012

The synthesis of new isomeric nucleosides (III) and (IV) with an oxabicyclo[3.3.0]octane fragment in the sugar moiety is performed by Vorbruggen glycosylation.
ChemInform Abstract: Inhibitory Effect on NO Production of Phenolic Compounds from Myristica fragrans
Authors: Min Byung Sun , et al. et al.
Published: February 2012

isolation, structure determination and antiinflammatory activity of three new phenolic compounds (I) and (II) along with four known compounds
ChemInform Abstract: Synthesis of 4‐[4‐(3‐Pyridinyl)imidazol‐1‐yl]‐1‐butylamine.
Authors: Cao Zhiling , Liu Bing , Liu Weiwei , Yao Guowei , Li Hongxia , Zou Ting
Published: February 2012

The title compound (VI), the side chain of the semisynthetic erythromycin derivative telithromycin, is obtained utilizing the HBr‐induced DMSO oxidation of 3‐acetylpyridine followed by direct transformation of the glyoxal formed into 4‐(3‐pyridyl)imidazole by a Debus reaction as the key steps.
ChemInform Abstract: A Simple Synthesis of the Pentacyclic Lamellarin Skeleton from 3‐Nitro‐2‐(trifluoromethyl)‐2H‐chromenes and 1‐Methyl(benzyl)‐3,4‐dihydroisoquinolines.
Authors: Korotaev Vladislav Yu. , Sosnovskikh Vyacheslav Ya. , Barkov Alexey Yu. , Slepukhin Pavel A. , Ezhikova Marina A. , Kodess Mikhail I. , Shklyaev Yurii V.
Published: February 2012

A variety of lamellarin‐type pentacyclic compounds are prepared by use of Grob synthesis, i.e.
ChemInform Abstract: Synthesis of (R)‐(+)‐Tanikolide, a Toxic and Antifungal δ‐Lactone from the Marine Cyanobacterium Lyngbya majuscula.
Authors: Matsuo Keizo , Hikita Junko , Nishiwaki Keiji
Published: February 2012

Starting from the known lactol (I) and using its stereogenic center at C‐4, title compound (VI), a brine‐shrimp toxic and antifungal marine metabolite, is obtained in a 5‐step procedure.
ChemInform Abstract: Indentification and Initial SAR of Silybin: An Hsp90 Inhibitor.
Authors: Zhao Huiping , Brandt Gary E. , Galam Lakshmi , Matts Robert L. , Blagg Brian S. J.
Published: February 2012

A library of silybin analogues [cf.
ChemInform Abstract: Bioactive C15 Acetogenins from the Red Alga Laurencia obtusa.
Authors: Ayyad Seif‐Eldin Nasr , Al‐Footy Khalid Omar , Alarif Walied Mohamed , Sobahi Tariq Rashad , Bassaif Salim Ahmed , Makki Mohamed Saleh , Asiri Abdullah Mohamed , Al Halawani Amani Yahya , Badria Adel Farid , Badria Farid Abd Al‐raheem
Published: February 2012

Three new C15 acetogenins (I)—(III) are isolated from the ether extract of the red alga Laurencia obtusa along with one known compound.
ChemInform Abstract: 1‐Aryl‐5‐(1H‐pyrrol‐1‐yl)‐1H‐pyrazole‐3‐carboxamide: An Effective Scaffold for the Design of Either CB1 or CB2 Receptor Ligands.
Authors: Silvestri Romano , et al. et al.
Published: February 2012

The compound (Ia) shows CB1 receptor affinity and selectivity (Ki = 2.3 nM, SI = 163.6) superior to Rimonabant and AM251.
ChemInform Abstract: Electrically Detected Magnetic Resonance in Dielectric Semiconductor Systems of Current Interest
Authors: Lenahan P. M. , Cochrane C. J. , Campbell J. P. , Ryan J. T.
Published: February 2012

Review: 30 refs.
ChemInform Abstract: Continuous Production of Carbon Nanotubes — A Review
Authors: Ying Lim Siang , bin Mohd. Salleh Mohamad Amran , bin Mohamed Yusoff Hamdan , Abdul Rashid Suraya Binti , bin Abd. Razak Jeefferie
Published: February 2012

Review: 47 refs.
ChemInform Abstract: Polar States of the Impurity System KTaO3: Li
Authors: Kleemann Wolfgang , Dec Jan , Miga Seweryn , Rytz Daniel
Published: February 2012

Review: 25 refs.
ChemInform Abstract: Recent Achievements in Chemical Studies of Heaviest Elements
Authors: Gaggeler H. W.
Published: February 2012

Review: recent studies on Cn and element 114; 21 refs.
ChemInform Abstract: Organometallic Chemistry in Non‐Classical Environments
Authors: Dyson Paul J.
Published: February 2012

Review: 67 refs.
ChemInform Abstract: A New Motif for Lewis Base Catalysis: Asymmetric Reduction of β‐Enamino Esters
Authors: Weickgennat Andreas , Oestreich Martin
Published: February 2012

Review: 18 refs.
ChemInform Abstract: Modern Methods for Shortening and Extending the Carbon Chain in Carbohydrates at the Anomeric Center.
Authors: Monrad Rune Nygaard , Madsen Robert
Published: February 2012

Review: 230 refs.
ChemInform Abstract: Gold‐Catalyzed Oxidation in Organic Synthesis: A Promise Kept
Authors: Della Pina Cristina , Falletta Ermelinda
Published: February 2012

Review: 54 refs.
ChemInform Abstract: Highly Enantioselective Synthesis of Tertiary Boronic Esters and Their Stereospecific Conversion to Other Functional Groups and Quaternary Stereocenters.
Authors: Scott Helen K. , Aggarwal Varinder K.
Published: February 2012

Review: 76 refs.
ChemInform Abstract: Synthetic Utilities of o‐Phenylenediamines: Synthetic Approaches for Benzimidazoles, Quinoxalines and Benzo[5,1]diazepines
Authors: Ibrahim Magdy Ahmed
Published: February 2012

Review: 192 refs.
ChemInform Abstract: Strong Bond Cleavage Promoted by Silyl Group Migration in a Coordination Sphere
Authors: Nakazawa H.
Published: February 2012

Review: 37 refs.
ChemInform Abstract: Recent Advances in the Chemistry of Pyrazoles. Part 2. Reactions and N‐Heterocyclic Carbenes of Pyrazole
Authors: Schmidt Andreas , Dreger Andrij
Published: February 2012

Review: 144 refs.
ChemInform Abstract: Reaction Mechanisms: Pericyclic Reactions
Authors: Tantillo Dean J. , Lee Jeehiun K.
Published: February 2012

Review: 56 refs.
ChemInform Abstract: Reaction Mechanisms: Radical and Radical Ion Reactions
Authors: Wille Uta
Published: February 2012

Review: 108 refs.
ChemInform Abstract: Multicomponent Reactions Promoted by Organosilicon Reagents
Authors: Wan Jie‐Ping , Liu Yunyun
Published: February 2012

Review: 78 refs.
ChemInform Abstract: Surface‐Science Models with Chemical Complexity
Authors: Hess Christian
Published: February 2012

Review: 32 refs.
ChemInform Abstract: Ruthenium Active Catalytic States: Oxidation States and Methanol Oxidation Reactions
Authors: Blume Raoul , Haevecker Michael , Zafeiratos Spiros , Techner Detre , Knop‐Gericke Axel , Schloegl Robert , Gregoratti Luca , Barinov Alexei , Kiskinova Maya
Published: February 2012

Review: 48 refs.
ChemInform Abstract: Charge Delocalization in Self‐Assembled Mixed‐Valence Aromatic Cation Radicals
Authors: Navale Tushar S. , Thakur Khushabu , Vyas Vijay S. , Wadumethrige Shriya H. , Shukla Ruchi , Lindeman Sergey V. , Rathore Rajendra
Published: February 2012

Review: 63 refs.
ChemInform Abstract: DNA‐Guided Display of Proteins and Protein Ligands for the Interrogation of Biology
Authors: Diezmann Franziska , Seitz Oliver
Published: February 2012

Review: 107 refs.
ChemInform Abstract: A Roadmap to Implementing Metal—Organic Frameworks in Electronic Devices: Challenges and Critical Directions
Authors: Allendorf Mark D. , Schwartzberg Adam , Stavila Vitalie , Talin A. Alec
Published: February 2012

Review: 93 refs.
ChemInform Abstract: Encapsulation, Release and Applications of LbL Polyelectrolyte Multilayer Capsules
Authors: Skirtach Andre G. , Yashchenok Alexey M. , Moehwald Helmuth
Published: February 2012

Review: 122 refs.
ChemInform Abstract: Evaluating f‐Element Bonding from Structure and Thermodynamics
Authors: Minasian Stefan G. , Krinsky Jamin L. , Arnold John
Published: February 2012

Review: 128 refs.