bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Physical Training Towards Body Balance in Overweight Condition
Authors: Rejeki Purwo Sri , Rahim Anita Faradilla , Prasetya Rizki Eka
Published: August 2019

An overweight individual has morphological changes in the muscle resulting functional impairment and can cause reduction in body balance system. Balance is an ability to maintain both static and dynamic equilibrium on various positions. An overweight person will experience a decrease in abdominal muscle strength and center of gravity shift. Physical training has positive effects to increase body balance. Stretching exercise maintains and increases the elasticity of muscle, tendon, fascia, ligament and joint motion and improve balance. Resistance exercise increases muscle performance which has benefit effect on balance system dynamically. The proprioceptive, an important part of balance maintenance to feel joint position or body when moving, can be improved by training that performed using balance board. Mechanoreceptor that is stimulated and the adaptation of the body's balance control that is influenced by balance board training results a good proprioceptive.
Risk Factors for Urinary Tract Infection in Hospitalized Patients
Authors: Setyorini Hadiati , Mardiana Nunuk , Tjempakasari Artaria
Published: August 2019

Introduction: Urinary tract infection (UTI) is the most common infection that can be fatal and has higher rate mortality especially in some patient. This study is aim to analyze risk factors for urinary tract infection in hospitalized patients for prevention and more aggressive approach can be taken.Methods: Consecutively, medical records of 285 patients with urinary analysis was recorded for risk factors and urine culture results if suspected UTI. Risk factors for sex, age, urinary catheter, urolithiasis, DM, and immobilization was analyzed with bivariate analysis and multivariate analysis.Results: From 285 patients, 92 patients had UTI with average age was 52.45 years old, 48 (56.49%) were female. Most common pathogen were E. coli (41.3%), Enterobacter sp. (8.8%) and Enterococcus faecalis (7.6 %). From bivariate analysis, geriatric age (>60 years) has RR 1.421 (95% CI 1.015-1.989, p=0.046) and immobilization has RR 1.861 (95% CI 1.266-2.738, p=0.007), whereas sex (RR 1.190 95% CI 0.851 – 1.664, p=0.310), diabetes (RR 1.171 95% CI 0.833 – 1.645, p=0.367), insulin usage (RR 0.900 95% CI 0.519 – 1.561, p= 0.703), glycosuria (RR 1.152 95% CI 0.741 – 1.791, p=0.522), and CKD (RR 1.475 95% CI 0.896 – 2.430, p= 0.126) give insignificant result. From multivariate analysis, urinary catheter has OR 4.506 (95% CI 2.312-8.872, p=0.000), urolithiasis with OR 4.970 (95% CI 1.931-12.787, p=0.001), and hyperglycemia has OR 2.871 (95% CI 1.485-5.551, p=0.002).Conclusion: Geriatric age and immobilization are risk factors for urinary tract infection, and urinary catheter, urolithiasis, and hyperglycemia are independent risk factors for urinary tract infection.
LDL Level in Ischaemic Stroke Patients at Dr. Soetomo General Hospital Surabaya
Authors: Rachmawati Mayori , Sugianto Paulus , Wardhani Rr. Indrayuni Lukitra
Published: August 2019

Introduction: Stroke is one of the top killers amongst the non-infectious diseases. Ischemic stroke dominates the rate by 87.0% amongst all type of strokes. One of the risk factors for stroke ischemic stroke is atherosclerosis which caused by lipid build-up in the arteries.Methods: This research is a retrospective study on secondary data. Admitted Ischaemic stroke patients. Lipid profile, and Barthel Index were collected from medical record and presented descriptively.Results: Of the 248 patients, 144 (58.1%) were men, mean age was 59.33. 61.7% ischemic stroke patients have their LDL level elevated, 59.7% HDL decreased, 39.1% total cholesterol elevated, and 33.9% TG elevated. This study also observe the dependency based on Barthel Index of the admitted stroke patients. 75% percents amongst subjects were categorized as “total dependece” are having their LDL level elevated.Conclusion: Most of stroke patients have elevated LDL and HDL while the TG and total cholesterol are mostly optimized. Stroke patients whose admitted with “total dependence” most likely to have elevated LDL in this study.
Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia
Authors: Salfi Qorina Nadya , Saharso Darto , Atika Atika
Published: August 2019

Introduction: Limited profile data of Cerebral Palsy (CP) patients in Indonesia leads CP to be a less-known disease. The aim of this study is to describe CP patient’s characteristics, including demographic aspect, gestation and birth history, and CP related condition in Dr. Soetomo General Hospital Surabaya, Indonesia.Methods: Cross-sectional study using medical records of CP patients in Dr. Soetomo General Hospital (Surabaya, Indonesia) Outpatient Installation for Pediatric Neurology from January 2016 to June 2018. Data processed descriptively.Results: From total 107 patients, 50 subjects met inclusion criteria. Mean age was 6.16 years old, with domination of male (3:2), live in Surabaya (56%), malnourished (24%), normal birth weight (80.9%), term age of birth (66.7%), spontaneous labor (60%), and also prenatal events as causes of Cerebral Palsy (69.5%). Pneumonia was found to be most among postnatal events leading to Cerebral Palsy (30%). Most of the type was spastic (9:1) with quadriplegic as the dominating one (64%). Congenital malformation was rarely found (38%), but co-morbidities were found in almost all sample (92%).Conclusion: Gestation and birth history of CP patients are mostly ranged normal. Prenatal etiology is found dominating as the cause of CP, therefore emendation in antenatal care (ANC) shall be considered. Analytical study about CP in Indonesia also must be improved because it is still hardly found.
Head Computed Tomography Images of HIV/AIDS Patients with Suspected Cerebral Toxoplasmosis in Dr. Soetomo General Hospital Surabaya
Authors: Wibawani Ria , Soeprijanto Bambang , Ferriastuti Widiana , Triyono Erwin A
Published: August 2019

Introduction: Toxoplasma gondii is an intracellular pathogenic parasite with the majority of co-infections occurring in HIV/AIDS patients. This study assesses the head computed tomography (CT) images of cerebral toxoplasmosis in patients with HIV/AIDS.Methods: This study was a cross-sectional design using head CT images of 35 HIV/AIDS patients with suspected cerebral toxoplasmosis. Variables include lesion type, location, size, CD4 count, and therapeutic result with anti-cerebral toxoplasmosis. All data analysed descriptively.Results: From total 110, 35 patients met the inclusion criteria. 24 patients (68.6%) were male and 11 (31.4%) female, average age, was 36.1. 8 patients (22.3%) had lesions in cortical, 31 patients (88.6%) had < 1 cm lesion. Single lesions mainly calcified and found in the right centrum semiovale while multiple lesions were subcortical. A hypodense lesion with rim or nodular contrast enhancement is found in 75% of patients with CD4 > 200 in contrast to slight rim contrast enhancement and perifocal edema in patients with CD4 < 200. 20 patients (57.4%) had improved condition after anti-toxoplasmosis therapy.Conclusion: Cerebral toxoplasmosis lesions in HIV/AIDS patients have various types of imaging findings, mostly multiple, with most frequent location being cortical and diameter < 1 cm. Total recovery is achieved in the majority of patients with therapy.
INTEREST OF USING E-COMMERCE CHANNELS BASED ON SOCIAL MEDIA TO IMPROVE THE QUALITY OF REGIONAL SUPERIOR PRODUCT MARKETING ON FEMALE GROUP OF CRAFTSMEN FROM SANITAIR KLASEMAN MALANG CITY
Authors: Puspitasari Ayu Febriyanti , Ervianty Rizka Miladiah , Dwikesumasari Phima Ruthia , Dwijayanti Ida Setya
Published: August 2019

Background: Industrial centers (UKM) in Malang are scattered throughout the city. According to data from the Malang Cooperative and UMKM Office, only 30% have gone online from the 70,000 UMKM currently available. This is an opportunity for young people to be able to help UMKM to go online. The main obstacles experienced by UMKM are financing problems, technology and product innovation, market research and inefficiencies. Purpose: To solve the problems of MSMEs in Malang City, especially in the field of technology and product innovation for women groups, UKM Craftsmen Sanitair Klaseman Malang. Method: Training on making e-commerce based marketing channels and social media which includes training on making e-commerce channels through social media and the internet. Results: The UKM of sanitation products in Malang were mostly dominated by 50% flower pots and 25% carvings. The use of social media for UKM partners had an impact on increasing orders from consumers through social media. The types of social media used was Whatsapp (100%), Instagram (55%), and Facebook (87.5%). Communication of sellers and buyers was effective and efficient through media chat messenger. Means of direct contact between sellers and buyers reached 87.5% through social media. Conclusion: Partners got increased orders from consumers after using social media. They could also grow their business bigger because they could have transaction directly with bank transfer payment method.
THE EFFORTS TO INCREASE KNOWLEDGE ABOUT BALANCED NUTRITION AT ELEMENTARY SCHOOL CHILDREN
Authors: Damayanti Ratih , Lutfiya Indah , Nilamsari Neffrety
Published: August 2019

Background: The balanced  nutrition  paradigm is currently unknown  to  the  general public, especially school-age children. The old paradigm of four healthy five perfects is still taught in schools. Whereas in the new paradigm of balanced nutrition, in addition to the principle of nutrition that must be consumed in a balanced manner, there is another message that must be conveyed, namely physical activity at least 30 minutes every day, regular exercise, drinking 8 glasses of water a day, washing hands before and after eating and always monitor your weight. Purpose: This community service activity aims to improve balanced nutrition knowledge in elementary school age children. Method: The method of community service is through lectures and games for ice breaking so that the atmosphere becomes more fun. Results: Most of the students of SDN Kalisari 1 Surabaya were female (54%), 10 years old (62%), and parents had jobs in the “other” category namely construction workers, janitors and farm workers (38%). As many as 83% of students have breakfast habits and 88% of students often access the internet. The level of student’s knowledge of balanced nutrition is included in the sufficient category (59%). There is a difference in the level of knowledge before and after counseling about the concept of balanced nutrition (α = 0.04). Conclusion: Efforts to increase knowledge of balanced nutrition with counseling and game methods are considered effective because there is a significant increase in the level of knowledge of SDN Kalisari 1 Surabaya students.
Dietary Contaminants and Their Effects on Zebrafish Embryos
Authors: Tye Marc , Masino Mark
Published: August 2019

Dietary contaminants are often an over-looked factor in the health of zebrafish. Typically, water is considered to be the source for most contaminants, especially within an aquatic environment. For this reason, source water for zebrafish recirculating systems is highly regulated and monitored daily. Most facilities use reverse osmosis or de-ionized water filtration systems to purify incoming water to ensure that contaminants, as well as pathogens, do not enter their zebrafish housing units. However, diets are rarely tested for contaminants and, in the case of manufactured zebrafish feeds, since the product is marketed for aquaculture or aquarium use it is assumed that the feed is acceptable for animals used for research. The following provides examples as to how contaminants could lead to negative effects on development and behavior of developing zebrafish.
KESIAPAN KAWASAN COMMERCIAL STRIP SURAKARTA UTARA BAGIAN BARAT SEBAGAI PUSAT AKTIVITAS BARU
Authors: Pamungkas Muhammad Rizal , Soedwiwahjono Soedwiwahjono , Miladan Nur
Published: August 2019

Berdasarkan RTRW Kota Surakarta tahun 2011-2031, kawasan Surakarta utara adalah kawasan strategis dari segi pertumbuhan ekonomi. Koridor komersial (commercial strip) di Surakarta utara bagian barat direncanakan melalui koridor jalan Adi Sumarmo, Mangunsarkoro dan Pierre Tendean. Pengembangan pada kawasan utara diperlukan untuk mengurangi beban aktivitas yang saat ini menjadi pusat aktivitas. Namun, pengembangan pada kawasan utara masih perlu perbaikan pada aspek fisik dan non-fisik seperti perbaikan infrastruktur penunjang dan tingkat investasi. Dengan begitu, perlu mengetahui bagaimana kesiapan kawasan commercial strip Surakarta utara bagian barat dari aspek fisik dan non fisik. Pendekatan penelitian ini adalah deduktif. Metode pengumpumlan data menggunakan teknik purposive sampling, observasi, dan kuesioner pada data primer sedangkan studi literatur pada data sekunder. Teknik analisis mennggunakan teknik statistik deskriptif, dan overlay peta tematik. Hasil dari penelitian ini adalah tingkat kesiapan pengembangan kawasan commercial strip di Surakarta utara bagian barat berada pada kategori cukup siap. Cukup siap berarti kawasan Surakarta utara bagian barat layak dikembangkan sebagai pusat aktivitas baru namun perlu dilakukan perbaikan pada beberapa aspek. Perlu perencanaan yang komprehensiff baik aspek yang sudah memenuhi kriteria maupun yang belum memenuhi kriteria kesiapan agar seluruh komponen kesiapan berada pada tingkat kesiapan yang memadai. Maka dari itu, perencanaan yang perlu dilakukan yaitu mengembangkan kawasan commercial strip dengan konsep strip-center development pada area di sekitar jaringan jalan agar pemanfaatan lahan menjadi lebih efisien dan mengurangi beban perjalanan
Muographic Observation of Density Variations in the Vicinity of Minami-Dake Crater of Sakurajima Volcano
Authors: Oláh László , Tanaka Hiroyuki K. M. , Hamar Gergő , Varga Dezső ,   Earthquake Research Institute, The University of Tokyo 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan,   Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest, Hungary
Published: August 2019

Muography is an innovative imaging technique used for inspecting and monitoring density-length variations of large-sized natural or human-made objects based on the measurement of the absorption rate of cosmic-ray muons. The first large-sized, high-resolution muography observatory based on Multi-Wire Proportional Chamber (MWPC) technology is being developed to monitor the mass density variations in the vicinity of Minami-dake crater of Sakurajima volcano. We found that the track rates provided by five ongoing tracking systems with a total surface area of 4 m2 are stable within ±3% from the backward direction, which demonstrates that the MWPC-based Muographic Observation System (MMOS) is applicable for the detection of average density variations above 2%, which is well below the practical limit of 5%. We quantified the time resolution of the designed muography observatory by modeling the muon flux across the volcano; the average density-length variation of 5 (10)% is expected to be detected within 5–20 (2–8) days at a 1σ (68%) confidence level (CL) with an MMOS orientation of 10.86° above the horizon. An automated analysis framework was developed as a data base for raw data reconstruction, analysis, and preparation, and which is accessible via web-server. We observed a more than 2σ CL decrease in average density across the West side of Crater A during the ongoing data collection period. The observed density decrease suggests that the amount of material has decreased inside Crater A due to the consecutive eruptions of Minami-dake during the data collection period from November 30, 2018 to January 11, 2019.
Rotational Osteotomy of the Humeral Shaft for Malunion in Osteogenesis Imperfecta
Authors: Nicholson Thema A. , Elder Alexandra , Gallen Kate , Namdari Surena
Published: August 2019

Case:

We report a case of an adult with osteogenesis imperfecta, who underwent humeral shaft osteotomy to correct an internal rotation deformity results from a humeral shaft malunion. The patient incurred a temporary radial nerve palsy.

Conclusions:

Humeral shaft malunion can be successfully treated with rotational osteotomy of the humerus through an anterior approach; however, the risk of radial nerve palsy exists and may be minimized by a posterior approach.
General Orthopaedic Roundtable: Workup of Recurrent Knee Effusions in a 57-Year-Old Male with Mild Knee Arthritis
Authors: Sasek Cody A. , Eggers-Knight Jill Tricia , Frost Charles , Salzmann Brad , Cloutier Dagan
Published: August 2019

The purpose of the JOPA Roundtable discussion is to give orthopaedic PAs insight on how each participating editorial board member treats certain orthopaedic conditions in his or her current practice. In this General Orthopaedic Roundtable, editorial board members with a general orthopaedic practice discuss the management of recurrent knee effusions in a 57-year-old male with mild knee arthritis. Participants share their knowledge and experience on the topic.
Private Midwives’ Perceptions on Barriers and Enabling Factors to Voluntary Counselling and HIV Test (VCT) in Bali, Indonesia
Authors: Lubis Dinar Saurmauli , Wulandari LPL , Suariyani Ni Luh Putu , Tresna Adhi Kadek , Andajani Sari
Published: August 2019

In Indonesia, more than half of pregnant women seek antenatal care (ANC) at private midwifery clinics. The midwives play an important role in advocating for voluntary counseling and testing (VCT) uptake among pregnant women during ANC. This study examined midwives’ perception of barriers and enabling factors with regards to refer pregnant women for HIV testing. The study was conducted in Denpasar City and Badung District, two localities in Bali with high HIV prevalence. Two focus groups discussions with 15 private midwives and five in-depth interviews were conducted. Data were transcribed verbatim and thematic analysis methods were used to examine patterns emerging from the data. Results showed that private midwives face personal barriers in the form of stigma as well as institutional barriers such as VCT operational hours that limit how and when they refer women for VCT. Barriers are strengthened by lack of support or reward from the health office. However, opportunities for integrated and comprehensive support systems within the health system and supportive social environment which would make it easy and rewarding for midwives to refer women to VCT clinics were seen as enabling factors. Increasing uptake of VCT is a necessity for eliminating mother to child HIV transmission.
Duration of Hormonal Contraception and Risk of Cervical Cancer
Authors: Kusmiyati Yuni , Prasistyami Annisaputri , Wahyuningsih Heni Puji , Widyasih Hesty , Adnani Qorinah Estiningtyas Sakilah
Published: August 2019

The use of long hormonal contraceptives can disrupt the balance of estrogen in the body, resulting in abnormal cell changes. This study aimed to determine a correlation between the duration of hormonal contraception and risk of cervical cancer. This study used a case-control design. The population  were patients who had examined at a cancer installation and obstetrics-gynecology polyclinic Dr. Sardjito Hospital in 2018. Case samples were 95 women have cervical cancer diagnosis and control were 95 women with a negative pap smear. Sampling with random sampling. Dependent variable cervical cancer and independent variable the duration of hormonal contraception are obtained from medical records. Cervical cancer is assessed by doctor’s diagnosis. Data analysis used logistic regression. Results showed that 44.7% of samples used long-term hormonal contraception (over 5 years). Length of use of hormonal contraception had a significant correlation with the incidence of cervical cancer (p-value < 0.01). Hormonal contraceptive use more than 5 years have a risk 4.2 times (95% CI 1.01-5.69) of cervical cancer than using less than 5 years after being controlled with the first marriage age and parity
Hematological Indices of Pesticide Exposure Rice Farmers in Southern Thailand
Authors: Kwanhian Wiyada , Yimthiang Supabhorn , Jawjit Siriuma , Mahaboon Junjira , Vattanasit Udomratana , Thirarattanasunthon Phiman
Published: August 2019

The most common pesticides used in rice farming are organophosphates and carbamates. These pesticides inhibit acetylcholinesterase (AChE) activity, resulting in excessive levels of acetylcholine accumulation and disrupted neurotransmission. This study compared AChE activity and hematological parameters between pesticide-using rice farmers, non-pesticide using rice farmers, and non-agricultural occupational groups (non-farmers). Pesticide residues that accumulated in rice and the water and soil of the study area were also determined. AChE activity of all participants showed 10 from 87 samples (11.49%) as borderline depressed, with 50% of these being pesticide-using farmers. Most of the hematological parameters were normal in all samples. However, platelet numbers of pesticide self-spraying rice farmers were significantly lower than non-self-spraying rice farmers. The results suggested that the use of pesticides during rice farming affected AChE activity and some hematological cells. In addition, pesticide residues in soil, water and rice in rice fields using pesticides were higher than in non-pesticide use areas. Results confirmed that the exposure rates of farmers using pesticides were at higher risk than farmers who did not use pesticides
Value of clinical examination in the assessment of penetrating neck injuries: a retrospective study of diagnostic accuracy test
Authors: Isaza-Restrepo Andres , Contreras Julián Andrés Quintero , Escobar-DiazGranados Jorge , Ruiz-Sternberg Ángela María
Published: August 2019

Background: There are many high-volume trauma centers in limited resource environments where a thorough clinical examination of patients may contribute to a more economic, accurate, and widely applicable method of determining the proper management of patients with penetrating neck injuries. The purpose of this study was to validate thorough physical examination as a reliable diagnostic tool in these patients.

Methods: We performed an observational retrospective study of a diagnostic accuracy test where we compared clinical findings (symptoms and soft signs on admission of the patient) with the definitive findings according to the gold standard test for each particular situation (selective studies, clinical observation and surgical exploration). The study was conducted at Hospital Occidente Kennedy (HOK) between August 2009 and June 2010.

Results: The sample consisted of the clinical records of 207 (n=207) patients who went to the emergency room for penetrating neck wounds at Hospital Occidente Kennedy (HOK) . Of the total sample, 36.2% (n=75) of patients were considered “asymptomatic” as they didn’t present with any soft signs of injury. Vascular soft signs were present in 57% (n=118) of the patients, soft signs of the airway and the upper gastrointestinal tract were present in 15.9% (n=33) and 21.3% (n=44) of the patients respectively. The sensitivity and negative predictive value (NPV) of any soft sign to determine injuries which require surgical repair was 97.4% [CI] [86.5%-99.5%] and 98.7% [CI] [92.8%-99.8%] respectively, with a range of confidence [CI] of 95%.

Conclusions: Our study´s main findings suggest that patients with neck injuries and no vascular, airway, or gastrointestinal soft sign can be safely managed with a conservative approach. It is important to emphasize the value of the clinical examination since there are many contexts in the modern world where a considerable amount of the population is afflicted by neck trauma and treated under conditions where technological resources are limited.
Do virtual renal clinics improve access to kidney care? an impact evaluation of a virtual clinic in east London
Authors: Hull Sally Ann , Rajabzadeh Vian , Thomas Nicola , Hoong Sec , Dreyer Gavin , Rainey Helen , Ashman Neil
Published: August 2019

BACKGROUND

Evidence from the UK national chronic kidney disease (CKD) audit, identifies deficits in the identification and management of CKD within primary care. Aligning the requirement of GPs for a responsive nephrology service, with the capacity of renal services and the need to prioritise patients with progressive disease requires a re-think of traditional models of care. Utilising the health data in the primary care electronic health record (EHR) to bridge the primary secondary divide is one way forward.

METHODS

We describe a novel community kidney service based in the renal department at Barts Health NHS Trust and four clinical commissioning groups (CCGs) in east London. An impact evaluation of the changes in service delivery used quantitative data from the virtual CKD clinic and from the primary care electronic health records (EHR) of 166 participating practices. Survey and interview data from health professionals were used to explore changes to working practices.

RESULTS

Analysis of the virtual clinic data shows a rapid rise in referrals. The majority (>80%) do not require a traditional face to face appointment but can be managed with advice to the referring clinician. The wait for a nephrology opinion fell from 64 to 5 days. The age adjusted referral rate was 2.5 per 1000 registered patients. Primary care clinicians expressed positive views including the rapid response to clinical queries, increased confidence in CKD management, improved access for patients unable to travel to clinic, and reported patient satisfaction. Nephrologists valued seeing the entire clinical record which improved clinical advice, but had concerns about the volume of referrals and changes to working practices.

CONCLUSIONS

It is feasible to develop ‘virtual’ specialist services using shared access to the primary care EHR. Such services expand capacity to deliver timely advice based on a review of the entire EHR. To use both specialist and generalist expertise efficiently such services are best supported by community interventions which engage primary care clinicians in a data driven programme of service improvement.
Interaction between serum FGF-23 and PTH in renal phosphate excretion, a case-control study in hypoparathyroid patients
Authors: Saki Forough , Kassaee Seyed Reza , Salehifar Azita Salehifar , omrani gholamhossein Ranjbar
Published: August 2019

Background

phosphate homeostasis is mediated through complex counter regulatory feed-back balance between parathyroid hormone, FGF-23 and 1,25(OH)2D. Both parathyroid hormone and FGF-23 regulate proximal tubular phosphate excretion through signaling on sodium- phosphate cotransporters IIa and IIc. However, the interaction between these hormones on phosphate excretion is not clearly understood. We performed the present study to evaluate whether the existence of sufficient parathyroid hormone is necessary for full phosphaturic function of FGF-23 or not.

Methods

In this case-control study, 19 patients with hypoparathyroidism and their age- and gender-matched normal population were enrolled. Serum calcium, phosphate, alkaline phosphatase,parathyroid hormone, FGF-23, 25(OH)D, 1,25(OH)2D and Fractional excretion of phosphorous were assessed and compared between the two groups, using SPSS software.

Results

The mean serum calcium and parathyroid hormone level was significantly lower in hypoparathyroid patients in comparison with the control group(P<0.001 and P<0.001, respectively). We found high serum level of phosphate and FGF-23 in hypoparathyroid patients compared to the control group (P<0.001 and P<0.001,respectively). However, there was no significant difference in Fractional excretion of phosphorous or 1,25OH2D level between the two groups. There was a positive correlation between serum FGF-23 and Fractional excretion of phosphorous just in the normal control population(P <0.001, r = 0.79).

Conclusions

Although the FGF-23 is a main regulator of urinary phosphate excretion but the existence of sufficient parathyroid hormone is necessary for the full phosphaturic effect of FGF-23.
TRAINING OF SOCIAL WORKERS IN THE INNOVATIVE EDUCATIONAL ENVIRONMENT OF A UNIVERSITY: CONCEPTUAL IDEAS AND INNOVATION MECHANISMS
Authors: Savelchuk Irina
Published: August 2019

The study presents a reflection of the problem of innovation training of future social workers in Ukraine in the context of forming the innovative educational environment of higher educational institutions.
Changes in the system of social workers training are characterized, frames of adding and widening their realization by conceptual ideas and mechanisms as to education in the field of social work are outlined. There is presented the multi-vector type of educational evolution in the field of social education that provides co-existence, development and interaction of conceptions, statements and views, different by their ideas as to the theoretical-methodological base of social workers training.
Solving the problem of functioning of the innovative educational environment of social workers training provides a purpose-oriented preparation to elaboration and implementation of social work innovations, based on ideas of pedagogical innovation, competence-oriented and project teaching, social partnership. This process is specially organized, purpose-oriented, dynamic, which socio-pedagogical conditions are realized in the common activity of teaching subjects due to integration of innovative possibilities of the educational environment and personal potential of a specialist, support of students’ ideas and initiatives, introduction of the method of situational modeling of social situations, provision of teaching subjects’ interaction as a special type of social partnership of state institutions and public organizations.
Such social workers training provides orientation on general scientific principles (system, open, variation, complex ones), concrete-scientific principles of organizing the educational environment (subjective activity, innovation, reflection, integration of the content of educational and other types of activity, principle of social partnership as realization of interaction between social institutions, organization of studio training).
It has been proved, that renovation of social workers training as a process of purpose-oriented support of the innovative content of environment possibilities corresponds to the characteristics (practice-orientation, polyfunctionality, openness, innovativeness) and may be provided by organization-managerial, scientific-methodological, activity-practical mechanisms.
ON THE ORIGINS OF SOME ENGLISH IDIOMS AND THE ADEQUACY OF THEIR DEFINITIONS IN THE GEORGIAN DICTIONARIES (II PART)
Authors: Dvalidze Nino
Published: August 2019

The aim of this article is to fill the informative gap and to overcome those difficulties which arise in case of not having the adequate interpetation or exact definition of the English idioms in the Georgian dictionaries.This paper investigates some idiomatic expressions and observes how often they are used in the modern English publicist texts from “The Guardian”, “Fortune”, “The Scotsman”, “The Independent” etc. whether they have preserved their original meanings or obtained some other new senses and coloring. More than this, the goal is to research if there is an adequate translation or interpretation of those English idioms in the Georgian language bilingual dictionaries. If there is not any, then the objective is how to make their adequate Georgian equivalents and, as a result to compose a new mini-dictionary of idioms. The urgent need for etymological study of idioms is also stimulated by the fact that the phraseology condensates the complex interaction of the culture and psychology of people, national self-being and their unique metaphoric mentality
The reaserch value is dectated by its outcome, namely, it will be the research not only of those idioms which have the adequate definitions in the Georgian dictionaries, but find out some cases of not having the right definition and in result to compile the mini be-lingual dictionary of idioms. It can be assumed, that it will make a siginificant contribution to the development of lexicography in Georgia.
DETERMINATION METHODS OF FOOD FIBERS CHARACTERISTICS IN MILK MIXTURES WITH THE MODIFIED FAT COMPOSITION
Authors: Grek Olena , Tymchuk Alla , Tsygankov Sergii , Savchenko Oleksandr , Ovsiienko Kіra , Ochkolyas Оlena
Published: August 2019

The article presents main determination methods of technological parameters of food fibers in milk mixtures of the modified fat composition.

The methods of studying the ability of food fibers to water and fat-absorption are offered. The values that characterize swelling parameters of vegetable ingredients in experimental mixtures are obtained.

The effectiveness of the method of IR-spectroscopy for indentifying and comparing water-binding forms in mixtures of food fibers with water and butterdish is proved.

The indices of thermal stability and degree of liquid fat outflow for mixtures with the modified fat composition with the maximal replacement of cream butter by 25 % of oil are obtained. The research results indicate objective possibilities for the effective use of food fibers Vicetal for stabilizing the structure and preventing consistence defects of products with the modified fat composition.
FEATURES OF DETERMINING THE QUALITY OF ETHNIC SOURDOUGHS AND WAYS OF USING THEM IN BAKING AND CATERING BUSINESS
Authors: Lebedenko Tetiana , Kozhevnikova Viktoriia , Novichkova Tamara , Kotuzaki Olena
Published: August 2019

The usage of various sourdoughs increases in order to expand the range and improve the quality, nutritional properties, and safety of bread products. Spontaneous sourdoughs with different formulas and preparation parameters are used in technologies of popular ethnic products. This paper is devoted to the study of wheat spontaneous sourdoughs, such as hop, pea-anise, and wine yeast sourdough. The effect of the grade and baking properties of flour, the inclusion of additional ingredients that can act as enrichers of the nutrient medium, carriers of additional fermentation microorganisms, as well as controllers of the species composition of the microflora, on their quality has been studied.

The basic scheme of preparing spontaneous wheat sourdough is developed; the basic stages and parameters of the dilution and production cycles are noted. The methods of controlling the process and quality of sourdough are described, the recommended values of the lifting force and titrated acidity are presented, as well as sensory characteristics.

It has been established, that the required fermentation ability and acid accumulation rate of sourdough are obtained in different time: 24 hours for wine yeast sourdough, 7–8 days for hop sourdough, and up to 15 days of a dilution cycle for pea-anise sourdough. The stabilizing effect of active substances of hop and anise on the quality of sourdough has been proven. Hop and pea-anise sourdough retain the necessary biotechnological properties for 90 days of propagation, but wine yeast sourdough loses its quality after 30 days, sourdough without additives loses it after 9 days.

The results of the research have theoretical and practical use, since the proposed scheme and approaches to developing the wheat sourdough technology and controlling their quality can be used to study various ethnic sourdoughs and technology of bread based on them. The experimental data on the quality of selected sourdoughs can be used to develop the technology of bread products with improved quality, nutritional value, and safety, ethnic products, and products "made according to old technologies".
Genetic Control of Seed Coat Darkening in Common Bean Cultivars from Three Market Classes
Authors: Rodrigues Ludivina L. , Rodrigues Luana A. , de Souza Thiago L. P. O. , Melo Leonardo C. , Pereira Helton S.
Published: August 2019

Common bean (Phaseolus vulgaris L.) cultivars with slow seed coat darkening benefit the growers by extending the seed storage period without losses in commercial quality. Seed coat darkening in pinto and carioca seeded common bean is controlled by recessive genes, but it is not known whether these genes are different or not. The objectives of this study were (i) to verify if the gene that controls seed coat darkening in common bean cultivars from different market classes is the same, and (ii) to evaluate the efficiency of the simple sequence repeat (SSR) marker Pvsd‐1158 and the single nucleotide polymorphism (SNP) marker PvbHLHp12804 linked to the Sd gene in identifying carioca and mulatinho seeded lines contrasting for seed coat darkening. Seventeen lines were used for genotypic and phenotypic evaluations in two trials, and F2:3 progenies obtained from crosses between one pinto bean line (Sd gene) and two carioca lines that have slow seed coat darkening were used in segregation tests. The result of the two markers was identical and shown 87.5% coincidence with phenotypic data. Only two lines, CNFM 11940 (mulatinho) and TAA Dama (carioca), exhibited slow seed coat darkening and marker alleles related to regular darkening. Therefore, there was recombination between the markers and the Sd gene, or there is another gene causing slow seed coat darkening in these lines. All F2:3 progenies exhibited slow seed coat darkening, indicating that there was no segregation. The two markers are efficient for assisted selection. Results of the genotypic evaluations and the segregation test indicating that the same gene (Sd) is responsible for seed coat darkening in pinto and carioca beans.
Features of venture capital funded enterprises: evidence from Slovakia
Authors: Freňáková Magdaléna , Kmeťová Oľga , Blaščák Pavel
Published: August 2019

This article contains an exploratory study of micro, small and medium sized enterprises (SMEs) funded by venture capital in conditions of the Slovak Republic. Their features specifically the number of employees and the affiliation to the industry branch in compliance with technological or knowledge demandingness were investigated. For that purpose two scientific hypotheses were verified. Verification of hypotheses was performed by the exact tests on the research sample consisted of 61 venture capital funded SMEs in the Slovak Republic in the time period 2001–2006. According to affiliation of enterprises to the category of micro, small and medium sized enterprises in our research sample, our assumption that the micro and small sized enterprises are more venture capital driven than medium sized enterprises was confirmed. The results showed that the majority of venture capital funded SMEs are micro-enterprises representing 60.66% and small sized enterprises with a share of 27.87%. According to affiliation of enterprise to the industry branch in compliance with its technological or knowledge demandingness in our research sample, our assumption that venture capital is related especially to the enterprises in high-tech sector was not confirmed and we can conclude that venture capital is related more to the enterprises operating in low-tech or medium low-tech sector than to the enterprises operating in high-tech or medium high-tech sector. The share of enterprises in high-tech sector was the lowest (only 3.28%) among all the sectors (low-tech, medium low-tech, medium high-tech and high-tech).
Identification of Phosphoinositide-3 Kinases Delta and Gamma Dual Inhibitors Based on the p110δ/γ Crystal Structure
Authors: Jia Wen-Qing , Feng Xiao-Yan , Liu Ya-Ya , Han Zhen-Zhen , Jing Zhi , Xu Wei-Ren , Cheng Xian-Chao
Published: August 2019

Background:

Phosphoinositide-3 kinases (PI3Ks) are key signaling molecules that affect
a diverse array of biological processes in cells, including proliferation, differentiation, survival, and
metabolism. The abnormal activity of PI3K signals is closely related to the occurrence of many diseases,
which has become a very promising drug target, especially for the treatment of cancer.
PI3Kδ/γ inhibitors can reduce toxicity concerns for chronic indications such as asthma and rheumatoid
arthritis compared with pan PI3Ks inhibitors.

Methods:

With the aim of finding more effective PI3Kδ/γ dual inhibitors, virtual screening,
ADMET prediction Molecular Dynamics (MD) simulations and MM-GBSA were executed based
on the known p110δ/γ crystal structure. Compound ZINC28564067 with high docking score and
low toxicity was obtained.

Results:

By MD simulations and MM-GBSA, we could observe that ZINC28564067 had more favorable
conformation binding to the PI3Kδ/γ than the original ligands.

Conclusion:

The results provided a rapid approach for the discovery of novel PI3Kδ/γ dual inhibitors
which might be a potential anti-tumor lead compound.
Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Cutaneous Melanoma
Authors: Basile Debora , Lisanti Camilla , Pizzichetta Maria A. , Baldo Paolo , Fornasier Giulia , Lo Re Francesco , Corona Giuseppe , Puglisi Fabio
Published: August 2019

Background:

Malignant melanoma is a skin cancer responsible for 90% of cutaneous cancer- related deaths. In recent years, breakthroughs in treatment strategy have revolutionized the prognosis in both early and advanced melanoma patients. In particular, treatment with monoclonal antibodies targeting co-inhibitory checkpoints or specific molecular pathways leads to a new era of promising options, by prolonging the survival time of these patients.

:

Moreover, unlike the chemotherapy that was used until some time ago, these new drugs have a good and more manageable toxicity profile. However, because of the recent introduction in clinical practice of the new agents, there is a learning curve among physicians regarding early recognition and management of the associated side effects.

Objective:

The analysis of the toxicity profiles of the different agents currently studied for the treatment of early and advanced melanoma, and the description of several relevant recent patents in this field, are the aims of this review.

Methods:

This is a systematically conducted review based on current clinical guidelines and on international Pharmacovigilance databases (AERS-Eudravigilance - WHO Vigibase).

Results:

Our systematic analysis outlines a comprehensive overview of the pharmacology, clinical application and the safety of recent anticancer drugs to treat melanoma, which can be an essential instrument for health professionals and researchers.

Conclusion:

The new oncological therapies against melanoma are based on increasingly specific biological and immunological targets. For this reason, the potential toxicities that are expected from patients would be less relevant than the systemic "classical" chemotherapy. However, the new therapies are not free from the risk of causing adverse reactions, some of which must be managed promptly and appropriately; moreover, the multiplicity of the metabolic pathways exposes the new target therapies to relevant potential interactions. This review can help to understand how important it is not to underestimate potential adverse drug reactions related to new targeted therapies.
Renewable energy based soil moisture metering system using a smartphone with IoT
Authors: Mishra Devesh , Yadav R. S. , Agrawal K. K.
Published: August 2019

The human civilization has started doing agriculture for its growth from the prehistoric era. Traditional methods of irrigation being followed up from early times are very inefficient and poor due to excess usage of water. In these techniques, plenty of water gets wasted as well as causes different diseases and fungus to plants because of overwater content in the soil generally named soil moisture. For the conservation of soil and water with an increase in efficiency of the farm, irrigation of soil water content monitoring system is very essential. Most of the water resources available globally are used for agricultural purpose only. To cope up with rising demands of efficient agriculture advanced soil moisture metering system have been developed and discussed to provide appropriate water to the crop. This advanced system gets powered through a solar panel a renewable source of energy. This system monitors the water content in the soil through sensors and as per the requirement watering of the plant is done. For processing and storage of a large amount of data storage cloud based Blynk service is used. This is a smartphone based moisture measuring system for appropriate irrigation using IoT. The primitive goal of this article is to monitor and metering of soil moisture to control the content of water in the plant. This is a mobile integrated smart moisture measurement system using IoT.
Experiencing Learning Mathematics and Reflection
Authors: Sterelyukhin Max
Published: August 2019

This study focuses on the assessment strategy that was designed in 2017-2018 academic year in two Calculus 12 classes. Students affect was at the centre of the research questions, thus clinical interviews were used to create data on the relationship with mathematics as well as personal reflections on the learning of mathematics in the given year and overall in students' experience in school. Grounded Theory was used as a research methodology bringing the emerging themes to the surface. The analysis showed that students were interested in reflecting on their learning and the new approach to assessment made a positive change in their relationship with leaning in a mathematics classroom.
The Allãh Lexicon and Arabic
Authors: Al-Saeedi Habeeb M. H.
Published: August 2019

beside their literal meanings, Allãh expressions have acquired over time a number of non-literal meanings that have become accessible to speakers as conventionalized meanings. The present study highlights that Allãh expressions can be used as devices to achieve certain conversational purposes such as holding the floor, changing the topic, closing a turn or ending a conversation. It is a conversation analysis study concerned with investigating the function of Allãh expressions; it aims at exploring what function these expressions may achieve in Arabic everyday interaction.
The Just War and the Mystry of Self Defense
Authors: Fahmyt Walid
Published: August 2019

The theory of the Just War initiated by St. Augustine must absolutely seek peace. To avoid this being the case, two phases are defined: Jus ad Bellum; the Jus in Bello. Thus, self-defense as a just cause is a concept often addressed in international law and its explicit recognition in Article 51 of the United Nations Charter has made it even more present. But, from the adoption of the Charter to today, there are many examples of actions or arguments of states based on self-defense that are more or less in phase with each other. The most recent references to the concept of self-defense have developed in a particularly volatile international context since the attacks of September 11, 2001, and the consequences that ensued. The relationship between the just war and self-defense raises some questions: can the anti-terrorism war, the preventive war and the war against non-state actors be considered part of the principle of self-defense? What are the criteria for Jus ad Bellum and Jus in Bello considered during the Self- defense?