bluuebunny/crossref_metadata_2025 huggingface dataset:
Alimentação, patrimônio e vida: desafios pós-pandêmicos
Authors: Falcão Leal Brotero Duprat Mariana , Le Guerroué Jean Louis , De Oliveira Areas Patrícia
Published: January 2023

O meio ambiente tem sido impactado, principalmente, por ações humanas. Mudanças climáticas, doenças pandêmicas, superexploração da sociobiodiversidade, insegurança alimentar e nutricional, até conflitos bélicos são alguns dos elementos deste contexto que exigem uma mudança da forma como vivemos no mundo. O presente artigo busca discutir as relações entre as ações do homem sobre o meio ambiente e das suas escolhas produtivas sobre a capacidade de promover saúde e garantir a conservação das espécies, inclusive a própria. Sem a pretensão de aprofundarmos os conceitos apresentados, buscamos delinear a dependência entre meio ambiente, produção e vida a partir da reflexão sobre a efetividade das cadeias de produção de alimentos, principalmente as relacionadas a sistemas tradicionais, para a garantia da segurança alimentar e nutricional, utilizando como principal marco temporal os anos de pandemia de Covid 19. Reconhecemos o patrimônio alimentar como possível ferramenta para a resiliência e a sustentabilidade dos territórios neste contexto de crise que se vivencia.
Ações de uma universidade comunitária no campo da psicologia para a promoção da saúde, da qualidade de vida e do bem-estar
Authors: Cleuri Pereira Santos Marciane , Alexandre Cidral  , Sofia Cieslak Zimath
Published: January 2023

O movimento de promoção da saúde em universidades não é tão recente e, aliado ao fato do momento desafiador enfrentado pela humanidade atualmente, tem levado as instituições, especialmente as universidades, a se debruçar cada vez mais sobre as questões de saúde, qualidade de vida e bem-estar, e o olhar da Psicologia sobre o tema tem se mostrado importante. Objetivou-se neste artigo evidenciar as ações sistematizadas de acolhimento desenvolvidas em uma universidade comunitária com a sua comunidade interna, visando à promoção da saúde, da qualidade de vida e do bem-estar das pessoas. Quanto à metodologia, o artigo resultou de um estudo de caso sobre as ações de uma universidade comunitária do norte catarinense, tendo como fonte de dados as evidências documentais da Gerência de Gestão de Pessoas e da Central de Relacionamento com o Estudante da instituição. A análise considerou o período de 2017 a 2021, sendo encontrado um total de oito serviços ofertados, sendo dois para estudantes e 6 para docentes e pessoal administrativo. A instituição tem utilizado o olhar da Psicologia no intuito de promover a saúde, a qualidade de vida e o bem-estar de seu público interno e tem perseguido o desafio de consolidar-se como uma universidade promotora da saúde, ao mesmo tempo em que se espelha nos objetivos do desenvolvimento sustentável.
Framework Nucleic Acids: A Promising Vehicle for Small Molecular Cargos
Authors: Zhang Junjiang , Li Jiayin , Sui Lei , Li Yanjing
Published: January 2023

Framework nucleic acids (FNAs), which are a series of self-assembled DNA nanostructures, are highly
versatile tools for engineering intelligent molecular delivery vehicles. Owing to their precise and controllable design
and construction, excellent programmability and functionality, as well as favorable intercalation between DNA and
small molecules, FNAs provide a promising approach for small molecule delivery. This review discusses the advantages,
applications, and current challenges of FNAs for the delivery of small molecular cargo. First, the physicochemical
and biological properties that make FNAs favorable for the transport of small molecules are introduced.
Thereafter, the classification of loaded cargos and the mechanism of combination between small molecules and
FNAs are summarized in detail, and recent research on FNA-based delivery systems and their applications are highlighted.
Finally, the challenges and prospects of FNA nanocarriers are discussed to advance their exploitation and
clinical adoption.
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by
CRISPR/Cas9
Authors: Liu Jie , Shang Xuyang , Yao Bingyi , Zhang Yuanjin , Huang Shengbo , Guo Yuanqing , Wang Xin
Published: January 2023

Background:

Carboxylesterase 2 (CES2) is mainly distributed in the human liver and gut, and plays an
active role in the metabolic activation of many prodrugs and lipid metabolism. Although CES2 is of great significance,
there are still few animal models related to CES2.

Objectives:

This research aims to construct Ces2c gene knockout (KO) rats and further study the function of CES2.

Methods:

CRISPR/Cas9 gene editing technology was used to target and cleave the rat Ces2c gene. Compensatory
effects of major CES subtypes both in the liver and small intestine of KO rats were detected at mRNA levels. Meanwhile,
diltiazem and aspirin were used as substrates to test the metabolic capacity of Ces2c in KO rats.

Results:

This Ces2c KO rat model showed normal growth and breeding without off-target effects. The metabolic
function of Ces2c KO rats was verified by the metabolic study of CES2 substrates in vitro. The results showed that
the metabolic capacity of diltiazem in KO rats was weakened, while the metabolic ability of aspirin did not change
significantly. In addition, the serum physiological indexes showed that the Ces2c deletion did not affect the liver
function of rats.

Conclusion:

The Ces2c KO rat model was successfully constructed by CRISPR/Cas9 system. This rat model can not
only be used as an important tool to study the drug metabolism mediated by CES2, but also as an important animal
model to study the physiological function of CES2.
Chalcones As Potent Agents Against Staphylococcus aureus: A Computational Approach
Authors: da Cunha Xavier Jayze , dos Santos Hélcio Silva , Machado Marinho Márcia , Nunes da Rocha Matheus , Rodrigues Teixeira Alexandre Magno , Coutinho Henrique Douglas Melo , Marinho Emmanuel Silva , Sucheta  , Kumar Nitin , Mishra Raghav
Published: January 2023

Background:

Studies on natural or synthetic products from chalcones have shown to be very
promising due to their peculiar structure that allows different possibilities of reallocation that will define
their diverse bioactivities in the creation of new substances. This creation is facilitated by the synthesis of
substances in conjunction with the molecular study, which allows a considerable advancement in
research, reducing the number of in vitro tests.

Objective:

This work focuses on the antibacterial activity of chalcones against Staphylococcus aureus,
which causes several diseases and is one of the main microorganisms with increasing resistance to
conventional drugs.

Methods:

Articles that studied antibacterial activity, efflux pump, or molecular docking were considered
complimentary analyses of chalcones. From these data, molecular docking and ADMET of the first five
chalcones were performed with the best activity found.

Results:

The result of the antimicrobial activity against Staphylococcus aureus was confirmed through in
silico study and pharmacokinetic data.

Conclusion:

The results of the antimicrobial activity of the most active chalcones against Staphylococcus
aureus were supported by in silico and pharmacokinetic studies, which not only confirmed their potential
to act against resistant strains but also established the future utility of chalcones as lead molecules or prototypes
for the synthesis of potent new antimicrobial agents against Staphylococcus aureus.
Development and Application of Chitosan Nanogel as a Sorbent for
Methotrexate Extraction
Authors: Mehdi-Alamdarlou Sanaz , Azadi Amir , Karbasian Mojgan , Ashrafi Hajar
Published: January 2023

Background:

Successful drug extraction from biological fluids is challenging due to
interfering factors and the trace levels of the target analytes.

background:

Today, successful drug extraction, especially in biological fluids, due to interfering factors and the trace level of targeted analytics, faces many challenges in a complex matrix. Therefore, providing a suitable and sensitive method that can be increased the efficacy of extraction method has been considered.

Objective:

We aimed to provide a suitable and sensitive method to increase the efficiency of
methotrexate extraction from biological fluids.

objective:

In this study, the chitosan-based nanogels, which were synthesized by the ionic gelation method were used for solid-phase microextraction of methotrexate

Methods:

Chitosan-based nanogel synthesized by the ionic gelation method was used for solidphase
microextraction of methotrexate from aqueous and plasma media. The nanogel was characterized
in vitro in terms of morphological characteristics (transmission electron microscopy), particle
size, polydispersity index (PDI), and zeta potential. High-performance liquid chromatography
was used to determine the methotrexate concentrations and extraction yield.

method:

The in vitro characterization of nanogels were performed by evaluation of morphological characteristics with TEM, determination of particle size, PDI, and zeta potential and also the HPLC assay method for determination of methotrexate concentration in different media and determination of extraction yield

Results:

A nanogel with an average size of 135.6 nm and PDI of 0.14 was used for the nanoextraction
of methotrexate in this study. The methotrexate concentration, nanogel amount, and extraction
time affected the extraction yield. Maximum recovery percentages of 75% and 69% were
achieved when extracting methotrexate from aqueous and plasma media, respectively.

result:

The nanogels with the average size of 135.6 nm and PDI of 0.14 were used for nanoextraction of methotrexate in this study. The concentration of methotrexate, amount of nanogel, and time of extraction were evaluated as an essential factor affecting the extraction yield.

Conclusion:

The high extraction yields in both studied media indicate that using chitosan-based
nanogel as a sorbent during the solid-phase microextraction of methotrexate is a promising prospect,
with potential uses for other drugs in different media. It seems that using nanogels can be
an excellent way to improve the extraction of drugs from biological environments.

other:

non
A Review on Advanced Nanomaterials for Antibacterial Applications
Authors: Jose Jephin K. , Cherian Christie Thomas , Balachandran Manoj
Published: January 2023

The management of infectious diseases is one of the major public health challenges of
the 21st century. Mutation of the microbes, biofilm formation, and other structural-morphological
behaviors have resulted in pathogens acquiring multi-drug resistance. The development of
advanced materials that can provide long-lasting and effective protection against harmful microbes
is becoming a need of the hour. Biocompatibility, efficient microbial inactivation, thermal
and chemical stability of nanomaterials help to reduce the excessive use of antibiotics and,
thus, to overcome antimicrobial resistance. Metal and metal oxide nanostructures, graphene,
carbon dots, and other two-dimensional materials exhibit excellent antimicrobial properties. This
review provides a comprehensive overview of antibacterial mechanisms and factors that help to
inactivate the bacteria by nanomaterials. It also points out the enhanced antibacterial behaviors
of the modified nanomaterials for future research concerns.

The management of infectious diseases is one of the major public health challenges of
the 21st century. Mutation of the microbes, biofilm formation, and other structural-morphological
behaviors have resulted in pathogens acquiring multi-drug resistance. The development of
advanced materials that can provide long-lasting and effective protection against harmful microbes
is becoming a need of the hour. Biocompatibility, efficient microbial inactivation, thermal
and chemical stability of nanomaterials help to reduce the excessive use of antibiotics and,
thus, to overcome antimicrobial resistance. Metal and metal oxide nanostructures, graphene,
carbon dots, and other two-dimensional materials exhibit excellent antimicrobial properties. This
review provides a comprehensive overview of antibacterial mechanisms and factors that help to
inactivate the bacteria by nanomaterials. It also points out the enhanced antibacterial behaviors
of the modified nanomaterials for future research concerns.
Breast Tissue Classification Method Based on Machine Learning
Authors: Li Yong , Tang Zhiling , Zhang Liangxi
Published: January 2023

Early detection and treatment of breast cancer are very necessary, and effective classification
of breast tissue is helpful for the diagnosis of breast cancer; so, a classification method named
FT_GA_GBDT is proposed. First, the correlations between the features and classification labels of
breast tissue samples were determined, and features with higher correlation were analyzed statistically
and combined by weight. Thus, feature transformation (FT) is realized. The datasets were then
enhanced by calculating the mean and root mean square of the feature attributes of each adjacent
odd- and even-row sample with both belonging to the same class. Finally, the genetic algorithm
(GA) was used to search the optimal parameters of the gradient boosting decision tree (GBDT)
model, and the optimal parameters were substituted into the GBDT to classify the breast tissue. In
addition, the K-nearest-neighbor (KNN), support-vector-machine (SVM) and GBDT methods were
also used to test the breast tissue classification. Results of 6-fold cross validation on three breast
tissue datasets showed that the average Precision, Recall, and F1 score obtained by the
FT_GA_GBDT method were better than those obtained by the KNN, SVM and GBDT methods. The
results further show that the FT algorithm and searching for the optimal hyper-parameters by the GA
were helpful in improving the performance of the breast tissue classification model, which is more obvious
when the correlations between features and classification labels are generally not high.
Informirani pristanak u psihotičnoj dekompenzaciji
Authors: Podgornjak Matea , Salopek Igor , Gutić Ena , Stanišić Anita , Hrvat Matić Lea
Published: January 2023

Pristanak obaviještenog pacijenta na liječenje nije samo potpisivanje pravno obvezujućeg dokumenta suglasnosti o liječenju, već i proces u kojem se pacijent osnažuje i postaje aktivni saveznik u liječenju. Valjani informirani pristanak podrazumijeva adekvatnost informacija, njihovo priopćavanje na primjeren način, dobrovoljnost pristanka i sposobnost pacijenta za donošenje odluke o liječenju. Kod osoba koje se liječe zbog psihičkih poremećaja ispunjavanje ovih uvjeta često predstavlja izazov. Psihički poremećaji mogu ugroziti sposobnost osobe za razumijevanje relevantnih informacija o prirodi svoje bolesti te kompromitirati njenu sposobnost odlučivanja o liječenju. No, psihijatrijska dijagnoza ne podrazumijeva da osoba nije u stanju odlučivati o svome liječenju, niti je isključuje kao ravnopravnog partnera iz terapijskog procesa. Prikazom 39-godišnjeg pacijenta koji razvija akutni psihotični poremećaj tijekom liječenja koronavirusne upale pluća istražujemo etičke dileme koje se javljaju u pristupu pacijentu prilikom liječenja psihotične dekompenzacije.
Control Biológico
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, Espinel Correal Carlos
Published: January 2023

La Agencia de Desarrollo Rural, ADR y la Corporación Colombiana de Investigación Agropecuaria, AGROSAVIA. En equipo continúan con tips para el manejo de Agroinsumos. Este video habla sobre el control biológico, cuando usamos enemigos naturales para bajar la cantidad de población que hay en un cultivo.
Uso de Biofertilizantes
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, Estrada Bonilla Germán Andrés
Published: January 2023

Un biofertilizante es un producto biológico a base de microorganismos benéficos que han sido aislados de los propios cultivos y que pueden optimizar la fertilización y absorción de nutrientes.
Experiences of Connecticut Community Health Center Patients With Telemedicine During the COVID-19 Pandemic
Authors: Delvy Roberta , Coman Emil , Sanchez Kelly , Powell Wizdom , Agresta Thomas
Published: January 2023

Background

Since COVID-19 rapidly made telemedicine a necessity, it is clear that virtual patient visits are going to be part of the new norm in continued outpatient care as we move into a postpandemic reality. However, we are still learning about patients’ experiences and preferences amid the rapid and widespread deployment of telemedicine.

Objective

The aim of this paper is to determine patients’ satisfaction with and experiences of telehealth services during the COVID-19 pandemic among those seeking care at Community Health Center Association of Connecticut member clinics.

Methods

Data were collected using a 24-question phone survey, which asked about telehealth use, frequency of telehealth visits, and barriers experienced. Participants were eligible if they aged 18 years or older, were English speaking, and were receiving care at 1 of 3 participating Community Health Center Association of Connecticut clinics.

Results

A total of 383 participants completed the phone survey throughout July 2021. The median age grouping was between 55 and 59 years, and the majority (63%) were female. Since COVID-19, in total, 78% reported having one or more audio-only telehealth visits (from 31% before), and 53% had one or more video telehealth visit (from 13% before). Most reported being very satisfied with their visits (86%) and that they felt confident in their provider’s ability to address their needs (74%). Most did not experience technical problems or have difficulty understanding how to connect to their provider. Even among older participants (60 years and older), only 28% reported having difficulty understanding how to connect to their provider, compared with 23% of 40- to 59-year-old patients and 18% of 18- to 39-year-old patients. Moreover, 45% reported being very likely to continue using telehealth even after the pandemic. However, 52% would have liked the option of in-person visits if they had been available in the past year.

Conclusions

These results suggest that most patients find telehealth visits an appropriate and accessible means of accessing health care, though some still like the option of seeing their provider in person. Future work should compare provider and patient experiences and identify optimal means of making the encounters mutually satisfying and beneficial.

Conflicts of Interest

None declared.
Predicting Clinically Significant Weight Loss in a Multimodal Commercial Digital Weight Management Program: Machine Learning Approach
Authors: Bannor Richard , Pagoto Sherry , Cardel Michelle I , Lee Alexandra , Foster Gary D , Xu Ran
Published: January 2023

Background

Generally, adherence to diet and physical activity in behavioral weight management programs predicts weight loss. Moreover, meeting attendance and platform or app use predict weight loss. Many weight-loss–prediction studies primarily use regression. However, little is known about the levels of adherence to specific web-based weight management program tools as well as behavioral and psychosocial variables that predict significant weight loss using machine-learning approaches.

Objective

In this paper, we aimed to examine variables that can predict clinically significant weight loss (≥5%) in a multimodal commercial digital weight management program, including levels of adherence to intervention tools and changes in behavioral and psychosocial states using machine-learning approaches.

Methods

We performed secondary analyses using data from a one-arm trial online WW (formerly Weight Watchers) weight-loss intervention program, lasting 6 months, that recruited US adults with a BMI range of 25-45 kg/m2. We used a WW Bluetooth scale and digital intervention tools such as mobile app for point tracking, weekly virtual workshops, weekly wellness check-ins and a Facebook group, and changes in psychosocial and behavioral variables (ie, food craving, Pittsburgh sleep quality index, diet, hunger, and physical activity). Using the receiver operating characteristics (ROC) curve, we identified the predictors of significant weight loss, as well as the associated cut points (CP) and area-under-curve (AUC) values for each variable. We further used a classification tree to confirm the importance of these predictors and assessed the out-of-sample prediction accuracies using 5-fold cross-validation.

Results

Participants (N=153) were 70% female and 66% White, with a mean age of 41.09 (SD 13.78) years, and had a mean BMI of 31.8 kg/m2 (SD 5.0). Approximately 51% of participants lost ≥5% weight. Using ROC curve, food tracking (CP≥9.4%; AUC=0.744; P<.001), increase in self-weighing (CP≥0.5; AUC=0.733; P<.001), wellness check-in attendance (CP≥31.3%; AUC=0.723; P<.001), and workshop attendance (CP≥35.4%; AUC=0.699; P<.001) were identified as significant predictors of achieving ≥5% weight loss. We confirmed the importance of these variables using classification tree, and together they achieved an out-of-sample prediction accuracy of 78%.

Conclusions

ROC curve and classification tree provided consistent results of predictors of clinically significant weight loss (ie, food tracking, increase in self-weighing, workshop attendance, and wellness check-in attendance). Our study extends the weight management literature by using machine-learning approaches to identify significant weight loss predictors and specific levels of these predictors needed to achieve clinically significant weight loss.

Conflicts of Interest

None declared.
Physicians’ and Individuals’ Attitudes Toward Digital Mental Health Tools: Protocol for a Web Survey Study With Physician and Stakeholder Interviews
Authors: Nogueira-Leite Diogo , Cruz-Correia Ricardo
Published: January 2023

Background

Digital transformation is impacting health care delivery and showing great market dynamism, bringing opportunities and concerns alike. Digital health applications are a vibrant segment where regulation is emerging, with Germany paving the way with its DiGA program. Simultaneously, anxiety and depression constitute global health concerns, and their prevalence is expected to worsen due to the COVID-19 pandemic and its containment measures. Portugal and its National Health System may be a useful testbed for digital health interventions seeking to manage anxiety and depression. This research methodology is very relevant in studies on mental health, making the protocol highly reusable.

Objective

The paper outlines the protocol for a research project on the attitudes of physicians and potential users toward digital mental health apps to improve access to care and patient outcomes and to reduce the burden of disease for anxiety and depression.

Methods

Web surveys will be conducted to acquire data from main stakeholders (physicians and academic community). Data analysis will replicate studies from Dahlhausen and Borghouts to derive conclusions regarding the relative acceptance and likelihood of successful implementation of digital mental health apps in Portugal.

Results

The findings of the proposed studies will elicit important information on how physicians and individuals perceive digital mental health apps interventions to improve access to care and patient outcomes and to reduce the burden of disease for anxiety and depression.

Conclusions

The results of the studies projected in this research protocol will have implications for researchers and academia, industry, and policy makers regarding the adoption and implementation of digital health mental apps and associated interventions.

Conflicts of Interest

None declared.
Non-Linear Static Analysis of Concrete Structure using Brick Infill Material: A Review
Authors: Singh Amit , Vyas Dr. J N
Published: January 2023

Abstract: The properties of masonary and its constitutive materials were reviewed, giving special emphasis to those aspects which contribute to a better understanding of the strength mechanism. Computer based procedures were developed for the rational evaluation of the strength of masonry subjected to compressive and shear stresses. The effect of pinching of the hysteresis loops in the response of infilled frames subjected to earthquakes was investigated. This paper was prepared to study various research work related to the Seismic analysis of reinforced concrete structures using brick as an infill material.
Real Time Indian Sign Language Recognition using Deep LSTM Networks
Authors: Rambhia Jainam , Doshi Manan , Lodha Rashi , Correia Stevina
Published: January 2023

Abstract: On our planet, people with speech and hearing disabilities are part of society. Communication becomes difficult when it is necessary to interact with survivors and the general public. In some races, people with disabilities practice different sign languages for communication. For people with speech and hearing disabilities, sign language is a basic means of communication in everyday life. However, a large portion of our community is unaware of the sign languages they practice, so bringing them into the mainstream is an incredible challenge. Today, computer vision-based solutions are still well received for helping the general public understand sign language. Many analysts are trying out one of his computer vision-based sign language recognition solutions, Recognition of Hand Gesture. Lately it’s been a popular area of research in various vernacular languages being used across the world. Through this research work, we propose a solution to this problem using Keypoint identification and Neural Network architecture for real time sign language recognition. This architecture uses a Long Short Term Memory architecture (LSTM) giving the best accuracy of 91.5% in prediction of words as well as phrases of Indian Sign Language
Smart Trolley System
Authors: Kodape Mayuresh M , Kinare Tejas , Mangrulkar Yash , Kasar Nakul , Bhatlawande Dr. Prof. Shripad
Published: January 2023

bstract: In this modern twenty-first century mostly all families like to spend time shopping in malls, shopping complexes and retail stores. In all these shops people usually carry trolleys on their own in which they collect the desired items and then locomote the trolley to the billing counter where they have to wait in long queues, but nowadays there is a need to convert the old traditional trolley with a modern automatic trolley, which is exactly our project. The main idea of the project is to automate the process of shopping in such a manner that we will scan the products using RFID attached to the products and an RFID reader attached to the trolley as well as display the total amount on the LCD. We also have included a feature to send a message to the customer's registered mobile number. This process not only helps in reducing the waiting time in the long queues and moving the trolley automatically but also helps in managing and checking the budget while shopping which indeed provides a huge difference in their shopping experience as well.
Educação em saúde: fatores de risco e proteção para doenças crônicas não transmissíveis em idosos
Authors: Carvalho Rodrigues Andreza , Franzner Donath Camila , Yamaguti Lenoch Camila , De Lima Kauling Matheus , Ramos Marques Renata , Peter Grillo Luciane
Published: January 2023

Introdução: Com o aumento significativo da expectativa de vida, o avançar do envelhecimento traz consigo a necessidade de implantação de ações voltadas à prevenção e à promoção de qualidade de vida à terceira idade frente às doenças crônicas não transmissíveis, entre elas as ligadas à saúde mental. Objetivo: Desenvolver atividades de educação em saúde frente aos fatores de risco e proteção para doenças crônicas não transmissíveis em idosos. Metodologia: A população foi constituída por idosos que responderam um questionário composto pelos indicadores monitorados pelo Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas e após foram aplicadas estratégias utilizando o guia alimentar para a população brasileira idosa de acordo com a realidade encontrada. Resultados: A amostra foi constituída por 67 idosos, sendo 70% (n=47) do sexo feminino. Encontrou-se 63% de sobrepeso, 69% assistiam televisão 3 horas ou mais por dia, 45% avaliaram sua saúde como regular/ruim, 78% apresentaram hipertensão, 39% diabetes, 19% depressão, 52% hipercolesterolemia, 81% consumiam hortaliças regularmente e 49% o recomendado e 54% praticavam atividades físicas. A partir do diagnóstico local foram desenvolvidas estratégias personalizadas como a distribuição de um imã de geladeira, salientando seis bons hábitos na alimentação do idoso, uma cartilha com sete desafios diários e um banner com os resultados do estudo para ser fixado no local dos encontros do grupo. Conclusão: As atividades de educação em saúde desenvolvidas possivelmente contribuirão para a diminuição dos fatores de risco e aumento nos de proteção para doenças crônicas neste grupo populacional.
Antinociceptive activity of marine derived chitosan coated triphala extract against formalin-induced zebrafish pain model
Authors:   Department of Research & Innovation, Saveetha School of Engineering, SIMATS Deemed University, Chennai-602 405, India, Karthick Raja Namasivayam S. , Avinash K.G.P. ,   Department of Biotechnology, Sathyabama Institute of Science & Technology (Deemed University), Chennai-600 119, India, Samrat K. ,   Department of Biotechnology, Manonomanium Sundaranar University, Tirunelveli-627 012, India, Krishnaveni P. ,   Department of Biotechnology, Manonomanium Sundaranar University, Tirunelveli-627 012, India, Bharani R.S.A. ,   Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bengaluru-560 054, India, Kumar R.G. ,   Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bengaluru-560 054, India, Kumar R.D. ,   Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bengaluru-560 054, India, Priyalakshmi B. ,   Department of Biotechnology, M.S. Ramaiah Institute of Technology, Bengaluru-560 054, India, Pattukumar V. ,   Department of Animal Sciences, Manonmanium Sundaranar University, Tirunelveli-627 012, India
Published: January 2023

Aim: The present study aimed to evaluate the antinociceptive effect of Triphala extract coated with marine derived chitosan against the formalin-induced adult zebrafish (Danio rerio) model. Methodology: Marine derived chitosan was extracted from Aspergillus niger and the extracted chitosan was coated witha commercial formulation of Triphala by a simple dispersion method. The prepared formulation was administrated to formalin-induced zebra fish model followed by studying changes in various behavioural parameters like swimming pattern, dark-light cycle pattern, antioxidants which include catalase, superoxide dismutase, lipid peroxidase, glutathione S. transferase, glutathione peroxidase and the expression pattern of inflammatory markers genes like tumour necrosis factor (TNF) and induced nitrous oxide synthase (, iNOs). Results: Marine derived chitosan-coated extract reveals notable antinociceptive activity by modulation of behavioural changes and inflammatory marker gene expression. The marine derived chitosan treatment group exhibits normal swimming patterns, dark-light cycle patterns, and morphological parameters as in the control group marine derived chitosan-coated Triphala treatment showed notable changes in the antioxidants. MARINE DERIVED CHITOSAN treatment did not induce any inflammatory signals, confirmed by a less expression pattern of inflammatory marker genes. Interpretation: These findings imply that marine derived chitosan-coated Triphala can be used as an antinociceptive agent through active phyto-principles involved in the molecular mechanism of pain manifestation. Key words: Antinociceptive, Chitosan, Marker genes, Triphala, Zebrafish
Predicting the incidence and severity of wheat aphids and development of a web-enabled forewarning system in India
Authors:   Agricultural Knowledge Management Unit, ICAR- Indian Agricultural Research Institute, New Delhi - 110 012, India, Kumar A. , Sharma R. ,   Agricultural Knowledge Management Unit, ICAR- Indian Agricultural Research Institute, New Delhi - 110 012, India, Singh B. ,   Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana - 141 004, India, Patil S.D. ,   Agricultural Research Station, Niphad, Mahatma Phule Krishi Vidyapeeth, Rahuri - 413 722, India, Srivastava C.P. ,   Department of Entomology and Agricultural Zoology, Banaras Hindu University, Varanasi - 221 005, India, Singh G.P. ,   Indian Institute of Wheat and Barley Research, Karnal - 132 001, India, Joshi A.K. ,   International Maize and Wheat Improvement Center, New Delhi - 110 012, India, India,   Borlaug Institute for South Asia, New Delhi - 110 012, India
Published: January 2023

Aim: Forecasting the incidence and severity of aphids, the major insect pest of wheat, is expected to significantly help in their management. In the present study, a set of weather-based models were developed to predict the timing and severity of Rhopalosiphum maidis infestation at Ludhiana falling under the North Western Plain Zone and R. padi at Niphad in the Peninsular Zone of India. Methodology: The weather indices-based regression models for two locations, Ludhiana and Niphad, were developed using the aphid population and weather data gathered over eight years (2006–14), and the models' predictive accuracy was successfully tested over four additional years (2014-18). The developed statistical models were transformed into three-tier architecture, web-based system, i.e. Presentation, application and data tier for dissemination of information. Results: The developed models can predict the crop’s age - when aphids first colonize the plants, when the aphid population attains the peak and the information about the peak intensity of the aphid population. For predicting the crop’s age at which population peaked at Ludhiana, the weighted interaction of the relative humidity (RH) in the evening and the number of hours of sunshine (NHS) along with the weighted interaction of minimum temperature and RH (morning) were important parameters while, at Niphad, the weighted NHS and the interaction of RH (morning and evening) were important. Likewise, for predicting the maximum aphid population at Ludhiana, the weighted interaction of minimum temperature and RH (morning) were important, while at Niphad, the key parameters were the weighted interaction of RH (evening) with the NHS. Interpretation: A prototype system developed to forecast the location-specific (Ludhiana and Niphad) infestation of wheat crops by aphids is expected to facilitate aphid management through an accurate forewarning at the locations.
Factores psicosociales y red de apoyo en trabajadores de una universidad pública
Authors: Fajardo-Zapata Álvaro , González-Valencia Yuri Lilian , Hernández-Niño Jenny Fabiola
Published: January 2023

Introducción. Los factores psicosociales en el trabajo consisten en las interacciones entre, el trabajo, el medio ambiente y las condiciones de la organización, con las capacidades del trabajador, sus necesidades, su cultura y su situación personal fuera del trabajo, a través de percepciones y experiencias que pueden influir en la salud, el rendimiento y la satisfacción en el trabajo. Objetivo. Caracterizar los factores psicosociales y el apoyo social laboral percibido por el personal académico y administrativo de una universidad pública. Materiales y métodos. Estudio descriptivo transversal orientado a caracterizar la percepción de los factores psicosociales y el apoyo social laboral de los funcionarios de una universidad pública, a través de dos instrumentos aplicados a los participantes en el estudio. Resultados. El análisis mostró que existe incomodidad y descontento en cuanto a algunas condiciones laborales, así mismo, los funcionarios mostraron tener una buena red de apoyo familiar y extra-laboral. Conclusiones. Es importante que la dirección de recursos humanos y el departamento de bienestar universitario realicen un análisis pormenorizado de los resultados con fin de establecer estrategias para mejorar los aspectos que fueron señalados como críticos por los funcionarios.
La enseñanza de Historia en Colombia: breve recuento historiográfico sobre sus inicios y reformas para su enseñanza en la actualidad
Authors: Cardona Osorno Cristian Felipe
Published: January 2023

El presente artículo propone realizar un recuento historiográfico sobre el origen de la asignatura de Historia en las instituciones educativas de Colombia; asimismo, revisar las metodologías implementadas en su enseñanza y conocer las reformas educativas que en algún momento se establecieron. Además, presentar algunas estrategias metodológicas que se están pensando alrededor de la obligatoriedad de su enseñanza bajo la ley 1874 del 2017, entre ellas, la propuesta didáctica de entender el cine como herramienta pedagógica oportuna para la enseñanza de la historia, que potencializa los procesos educativos y le permite al docente un abanico de posibilidades para su enseñanza.
Endocardial pacing in a single-ventricle patient with tricuspid atresia- a case report
Authors: Yamini-Sharif Ahmad , Yaghoubian Ramin , Ghaderian Homa , Moosavi Najme-Sadat
Published: January 2023

The use of endocardial pacing in patients with univentricular hearts is
limited. However, it may be the better option when the risk of surgery
is high. We report a case of complete heart block who underwent left
ventricular endocardial pacing due to the high risk of epicardial lead
placement.
Splenic Hematoma Following Acute Pancreatitis, and the role of Conservative Management: A Case Report
Authors: Ali Zulfeqar , Karim M.Masood , Javeed Maria , Khan Qaisar Ali , Farkouh Christopher , Zepeda David , Abdi Parsa , Anthony Michelle , Farkouh Mathew , Khan Arooba , Ghosh Bikona
Published: January 2023

Splenic hematoma following an acute pancreatitis is a rare complication
which is thought to be due to the distribution of pancreatic exudates to
the spleen. We presented a case of a 44-year-old patient with acute
pancreatitis who developed splenic hematoma. He responded well to
conservative management and the hematoma resolved.
Applicability of the Wöhler Curve Method for fatigue life assessment of metallic materials in low and extremely low cycle fatigue regime
Authors: yan xiangqiao
Published: January 2023

In this letter, an attempt is made that, in low and extremely low cycle
fatigue regime, applicability of the Wöhler Curve Method is examined
using experimental fatigue data from the literature. The conclusion is
that the Wöhler Curve Method is well suitable for fatigue life
assessment of metallic materials in low and extremely low cycle fatigue
regime.
Development of two-leaf photosynthetic model sensitive to chlorophyll content and its couple with wheat growth model
Authors: Tang Yining , Wang Jiacheng , Hong Yifan , Guo Caili , Zheng Hengbiao , Yao Xia , Cheng Tao , Zhu Yan , Cao Weixing , Tian Yongchao
Published: January 2023

Crop growth model simulates the response of photosynthetic rate to
nitrogen (N) dynamic by calculating critical N concentration. However,
critical N concentration cannot describe the physiological effect of N
dynamic to photosynthesis. In this paper, a Two-leaf Photosynthetic
Model Sensitive to Chlorophyll Content (TPMSCC) was developed and
coupled with the crop growth model (WheatGrow) to improve the mechanism
of N dynamics on photosynthesis. The simulating results of TPMSCC
revealed the high sensitivity of LCC on photosynthesis. The
relationships of LCC to the maximum photosynthetic rate (A
) and the initial light use efficiency (ɑ) simulated
by TPMSCC were linear and logarithmic. In addition, canopy
photosynthetic rate benefited from the increase of diffuse radiation
fraction (DRF) except for the condition of dense canopy at high solar
zenith angle. The optimized WheatGrow performed better than WheatGrow on
describing the response of N level on biomass accumulation and
distribution in different organs.
OPERATING SURPLUS OF LGUS IN THE CONTEXT OF LEGAL CHANGES RESULTING IN A DECLINE OF LGUS' CURRENT INCOME FROM PIT
Authors: Kowalska Iwona
Published: January 2023

The issue of an operating surplus of local government units (LGUs) is gaining significance due to, inter alia, the enactment of legal changes resulting in a decline in the current income of LGUs from PIT. The purpose of the research is evaluation of the development of the LGUs' operating surplus in the context of legal changes (enacted in 2019-2022) causing the said decline as well as the evaluation of the mechanisms compensating LGUs for that decline. The following were applied to accomplish the research objective:(1) quantitative analysis, taking into consideration the data of the Ministry of Finance presented in the reports on LGUs' budget implementation for 2020-2021 and multi-annual financial forecasts for the LGUs’ budget plan for 2022; (2) review of source literature and legislation related to the research subject. The analysis performed for the years 2020-2022 shows that the period of growth in the value of the operating surplus in all types of LGUs in 2021 in comparison to 2020 is followed by a significant decline in its value in 2022 (as planned). Across Poland, this applies to: municipalities, cities with county rights and voivodeships. Whereas, in the case of counties (on a Poland-wide scale), no operating surplus has been planned at all for 2022. The above situation may result not only in a decline in the capacity to finance investments from the operating surplus in LGUs, but also in the differentiation of these capacities within specific LGU types. Increased differentiation of this phenomenon in specific local governments may be affected by, inter alia, the adopted system of criteria of distribution of funds as part of the compensation for the decline in current income from PIT (especially in the development part of the general subsidy).
Analiza konkurencyjności polskiego eksportu nawozów azotowych
Authors: Zalewski Arkadiusz
Published: January 2023

Eksport odgrywa ważną rolę w funkcjonowaniu sektora nawozów azotowych. Polska jest w UE jednym z największych eksporterów nawozów azotowych, a obroty handlowe systematycznie rosną. Celem artykułu była analiza konkurencyjności polskiego eksportu nawozów azotowych w latach 2004-2012 w handlu światowym. Badano saldo wymiany handlowej. Do oceny konkurencyjności zastosowano wskaźnik ujawnionych przewag komparatywnych oraz wskaźnik pokrycia importu eksportem. Badania wykazały, że w badanym okresie poprawiło się dodatnie saldo handlu zagranicznego nawozami azotowymi, jednak konkurencyjność wymiany handlowej uległa pogorszeniu.
Produktywność gospodarstw rolnych w Polsce na tle innych krajów
Authors: Grochowska Renata , Mańko Stanisław
Published: January 2023

W niniejszej pracy dokonano krótkiego przeglądu badań pokazujących szacunki wskaźnika całkowitej produktywności rolnictwa (Total Factor Productivity – TFP) w skali globalnej i w wybranych krajach. Zaprezentowano także wyniki własne, dotyczące analizy TFP w rolnictwie polskim w latach 2004-2012. Analizę wykonano w oparciu o dane rachunkowe gospodarstw rolnych z Polskiego FADN. Wskaźniki TFP policzono dla czterech typów gospodarstw rolnych, tj. polowych, mlecznych, trzodowych i mieszanych, na podstawie modeli regresji Cobb-Douglasa. Przeprowadzona analiza wykazała, że całkowita produktywność rolnictwa polskiego nie odbiega od krajów UE-15. Podobnie jak w tych krajach, polskie gospodarstwa mleczne charakteryzowały się najwyższym TFP. Niepokoi jednak średnioroczny spadek TFP w poszczególnych typach rolniczych w analizowanym okresie. Jest to głównie skutek znacznego obniżenia się produktywności w latach 2008-2009, co wiązało się z ogólną koniunkturą w tym okresie.
Źródła rent gruntowych w rolnictwie Unii Europejskiej
Authors: Czyżewski Bazyli
Published: January 2023

Występowanie rent gruntowych we współczesnym rolnictwie UE potwierdza wieloletni rosnący trend cen ziemi rolniczej. Nasuwa się jednak pytanie, czy są to przede wszystkim renty różniczkowe związane z różną wydajnością gruntów rolnych, czy renty absolutne w klasycznym rozumieniu, czy też renty instytucjonalne w ujęciu teorii wyboru publicznego? Cele artykułu mają przede wszystkim wymiar teoriopoznawczy. Podejmuję w nim próbę weryfikacji koncepcji renty gruntowej, którą sformułowałem na podstawie badań przeprowadzonych w Polsce. Tym razem jednak zakres badań obejmuje pełen przekrój struktur agrarnych UE. Według wspomnianej koncepcji źródłem współczesnej renty gruntowej jest wyższa oczekiwana produktywność kapitału w rolnictwie niż w jego otoczeniu rynkowym. U podstaw tej tezy leżą kluczowe założenia ekonomii neoklasycznej oraz nowej ekonomii klasycznej. Przeprowadzone badania odpowiadają m.in. na pytanie, gdzie (w jakich krajach i strukturach agrarnych) ewentualna różnica wspomnianej produktywności kapitału jest największa i na ile wynika to z subsydiów z WPR, a na ile z czynników strukturalnych? Ogólna konkluzja sprowadza się do tego, że nawet bez płatności obszarowych wyższa produktywność nakładów kapitału w rolnictwie niż w jego otoczeniu jest powszechnym zjawiskiem w UE.
Sektor mięsa wieprzowego w Polsce i na świecie w latach 2000-2012
Authors: Wojtasik-Kalinowska Iwona , Guzek Dominika , Głąbska Dominika , Konarska Małgorzata , Sakowska Anna , Wierzbicka Agnieszka
Published: January 2023

Mięso wieprzowe odgrywa kluczową rolę na polskim, europejskim, jak
i światowym rynku mięsa. W artykule scharakteryzowano zmiany wielkości produkcji trzody chlewnej, spożycia mięsa wieprzowego, a także jego eksportu i importu w latach 2000-2012. Na światowym rynku mięsa w roku 2012 wieprzowina zajmowała pierwsze miejsce pod względem wielkości produkcji (110,8 mln ton), natomiast w Polsce plasowała się na drugim miejscu – za mięsem drobiowym (2,2 mln ton). W analizowanym okresie wieprzowina była najchętniej spożywana wśród wszystkich gatunków mięsa, a jej spożycie utrzymywało się na stabilnym poziomie i wynosiło w 2000 roku 39,2 kg/osobę, a w 2012 roku – 39,0 kg/osobę. W 2012 r. znaczący popyt zagraniczny na mięso wieprzowe przyczynił się do wzrostu jego eksportu z Polski. W roku tym eksport żywca, mięsa i jego przetworów wynosił 588,4 tys. ton i w porównaniu z rokiem poprzednim wzrósł o ok. 14,5%. Natomiast import zwiększył się w tym czasie o około 9,8 %.
Społeczne, prawne i ekonomiczne aspekty rozwoju gospodarki leśnej w lasach prywatnych
Authors: Wysocka-Fijorek Emilia
Published: January 2023

W Europie właściciele lasów prywatnych mają kluczową rolę w prowadzeniu zrównoważonej gospodarki leśnej, utrzymaniu produkcyjności lasów oraz zaspokojeniu potrzeb społeczeństwa na drewno. Lasy prywatne w Polsce to 18,4% powierzchni lasów. Charakteryzują się one dużym zróżnicowaniem, zarówno ze względu na wielkość kompleksów leśnych, jak i powierzchnię należącą do jednego właściciela, a także rozmieszczenie w obrębie kraju. Obecnie funkcjonujące rozwiązania prawne w zakresie lasów prywatnych są niewystraczające. Niezbędne zdaje się być wprowadzenie możliwości organizowania się właścicieli lasów tak, aby mogli wspólnie prowadzić gospodarkę leśną. W tym, też kontekście należy zaktualizować obecnie obowiązujące przepisy lub wprowadzić nowe regulacje prawne. W coraz większym stopniu widoczna jest potrzeba zwiększenia efektywności gospodarowania w lasach prywatnych w Polsce oraz wzmocnienia ich roli środowiskotwórczej.
Produkcja i ceny owoców z upraw ekologicznych
Authors: Zmarlicki Krzysztof , Brzozowski Piotr
Published: January 2023

W opracowaniu, na podstawie dostępnej literatury, przedstawiono zarys stanu produkcji ekologicznej owoców na świecie i w Polsce. W celu oceny sytuacji na rynku owoców ekologicznych przeprowadzono analizę porównawczą cen jabłek i truskawek z certyfikowanych plantacji ekologicznych i z produkcji konwencjonalnej na wybranych rynkach hurtowych w USA, Francji i w handlu detalicznym w Polsce. Ponadto na podstawie badań ankietowych przeprowadzono analizę czynników mających wpływ na funkcjonowanie rynku owoców ekologicznych w Polsce i oczekiwań ze strony ich potencjalnych konsumentów.