bluuebunny/crossref_metadata_2025 huggingface dataset:
Diversität und Digitalität in der spätmodernen Gesellschaft
Authors: Breiwe René
Published: September 2023

Die (zunehmende) Thematisierung und Umsetzung inklusiver Medienbildung vollzieht sich im Kontext widersprüchlicher gesellschaftlicher Transformationsprozesse. Diese beziehen sich einerseits auf Diversifizierungsentwicklungen bzw. den Wandel zur Kultur der Diversität, die sich beispielsweise in entscheidenden (rechtlichen) Schritten wie der Verabschiedung der UN-BRK oder der Anerkennung des Dritten Geschlechts (vgl. §22 PStG) manifestieren. Andererseits erfolgen Mediatisierungsprozesse bzw. ein Wandel zur Kultur der Digitalität, die Alltagspraktiken fortlaufend (subtil) sowie auch Mechanismen der Inklusion (und Exklusion) verändern. Gleichzeitig sind die gesellschaftlichen Verhältnisse geprägt von kapitalistischen bzw. neoliberalen Logiken und Strukturen und können als eine an Singularitäten ausgerichtete Gesellschaft der Spätmoderne verstanden werden. Diesen Umständen können sich schulische Inklusionsprozesse bzw. Formen inklusiver Medienbildung nicht entziehen. Vor dem Hintergrund der Diversifizierung (zu einer Kultur der Diversität) und Digitalisierung (zu einer Kultur der Digitalität) in kapitalistischen Verhältnissen der spätmodernen Gesellschaft wird Inklusive Medienbildung somit in den Kontext widersprüchlicher Verhältnisse gestellt und ein begrifflich-konzeptionelles Plädoyer für eine reflexive inklusionsorientierte Medienbildung vorgenommen.
Inklusive Medienbildung in beruflichen (Bildungs-)Kontexten
Authors: Sonnenschein Nele
Published: September 2023

Im Diskurs um Inklusive Medienbildung stellen Überlegungen mit Bezug auf berufliche (Bildungs-)Kontexte weitgehend eine Leerstelle dar, obgleich dieses Handlungsfeld angesichts der fortlaufenden Digitalisierung der Arbeitswelt für eine Auseinandersetzung mit Fragen an der Schnittstelle von Inklusion, Teilhabe, digitalen Medien und Medienbildung hochgradig relevant erscheint. So gilt es beispielsweise, Möglichkeiten für die berufliche Teilhabe von Menschen mit Behinderungen unter den spezifischen Bedingungen digital geprägter Arbeitsprozesse und -aufgaben näher zu betrachten. Lediglich aus einigen innovativen Forschungs- und Entwicklungsprojekten, die sich vorwiegend praxisorientiert mit Möglichkeiten zur Förderung beruflicher Inklusion durch digitale Medien auseinandergesetzt haben, liegen erste konzeptionelle Ansätze vor. Diese werden im Beitrag anhand ausgewählter Beispiele aufgearbeitet und aus der Perspektive der Inklusiven Medienbildung diskutiert. Die vorliegenden Ansätze lassen sich mit Blick auf die adressierten Zielgruppen, fachlichen Kontexte sowie die Konzepte zum inklusiven Medieneinsatz insgesamt als sehr spezifisch beschreiben und bedürfen einer theoretischen und konzeptionellen Weiterentwicklung. Als gewinnbringende Perspektive für die Umsetzung einer Inklusiven Medienbildung in beruflichen (Bildungs-)Kontexten stellt sich in diesem Zusammenhang ein pädagogisch begleiteter Einsatz digitaler Medien heraus, der auf Unterstützung im Arbeitsprozess, im beruflichen Wissens- und Kompetenzerwerb wie auch auf Persönlichkeitsbildung abzielt.
BEHAVIOR OF MADRASAH HEADS IN CREATING AN EFFECTIVE MADRASAH CULTURE
Authors: Safi'i Asrop
Published: September 2023

Madrasah principals play an important role in creating an effective madrasah culture. This research analyzed the behavior of the madrasah head in fostering an effective culture in human resources and services in the institution he leads. The research was conducted in 9 madrasah in Tulungagung Regency. Data was obtained through interviews and observation techniques. The research results show that efforts to create an effective madarasah culture are carried out through an adaptive and visionary leadership style. These include delegating tasks proportionally, having effective communication skills, being able to foster motivation in subordinates, and exercising measurable control. This research shows how a madrasah head has a big influence in fostering an effective work culture, if he can optimize the potential and he has power.
Entanglement classification via operator size
Authors: Wu Qi-Feng
Published: September 2023

In this work, multipartite entanglement is classified by polynomials. I show that the operator size is closely related to the entanglement structure. Given a generic quantum state, I define a series of subspaces generated by operators of different sizes acting on it. The information about the entanglement is encoded into these subspaces. With the dimension of these subspaces as coefficients, I define a polynomial which I call the entanglement polynomial. The entanglement polynomial induces a homomorphism from quantum states to polynomials. It implies that we can characterize and find the building blocks of entanglement by polynomial factorization. Two states share the same entanglement polynomial if they are equivalent under the stochastic local operations and classical communication. To calculate the entanglement polynomial practically, I construct a series of states, called renormalized states, whose ranks are related to the coefficients of the entanglement polynomial.
Assessing market efficiency in Palestine Securities Exchange (PSE) market at weak form: Analysis from 2010–2022
Authors: Mukarker Elias
Published: September 2023

The efficient market hypothesis (EMH) asserts that financial markets are efficient, meaning that current market values of stocks incorporate all available information. This study examines the weak-form efficiency of Palestine Stock Exchange stocks using the indices returns from 2010 to 2022. The study used parametric tests (Augmented Dickey-Fuller (ADF) unit root, serial autocorrelation) and nonparametric tests (Phillips-Perron (PP) unit root, run test, variance ratio test). The findings of these tests provide insights into the behavior of the Palestine Stock Exchange market. The run test outcomes reveal a statistically significant pattern in the data for general, insurance, and service indices, with a p-value below the significance level. Furthermore, the unit root tests indicate statistical significance for all indices with 0.00 p-values and t-statistic below the critical values of –2.86 for level and intercept, and –3.14 for level, trend, and intercept, signifying that the indices returns are stationary. In addition, serial autocorrelation test show that the general and Al-Quds indices show statistically significant links between consecutive observations at all four lags. However, the insurance, investment, and services indices show statistically significant results on three lags. The variance ratio test results challenge the random-walk hypothesis for all indices except industry and insurance. With low probability values, a discernible, long-term, predictable pattern is evident in the Palestine Stock Exchange indices. The analysis reveals that Palestine Stock Exchange index returns exhibit nonrandom behavior, suggesting predictability and patterns in daily returns, indicating the possibility of exploiting market inefficiencies in investment strategies.
Going Back with Glee: A Case Study of Indonesian Migrant Workers Engaging in Circular Migration
Authors: Setijaningrum Erna , Kassim Asiyah , Triana Rochyati , Dzulfikri Reza
Published: September 2023

Driven by a wide range of social and cultural forces, circular migration has become a prominent phenomenon in the contemporary world, and it is especially common among Indonesian migrant workers. The research delved into what pushes Indonesian migrant workers to going back to host countries for employment after returning to their home country. A case study approach was employed by which a total of 24 semi-structured interviews were conducted with Indonesian migrant workers from Blitar, Malang, Ponorogo, and Tulungagung in East Java, Indonesia. The research reveals that non-monetary incentives such as supportive and amicable workplace environments, including the possibility of career advancements and adequate accommodations, as well as productive and family-oriented communities, act as important motivators for Indonesian migrant workers to go back to host countries. Furthermore, the research adds to the widening topography of migration studies by which it provides a broader picture in painting the “human” rationality behind circular migration in Global South.
Analysis of hydrological regime evolution and ecological response in the Min River, China
Authors: Wang Hongxiang , Wang Baoliang , Yang Huan , Zhou Haotong , Chen Hao , Guo Wenxian
Published: September 2023

Natural fluctuation of the hydrological regime is the key to maintaining river ecosystem function. Given the shortcomings of previous studies on hydrological regime change and the ecological response of the Min River, this study combined two change degree evaluation methods and Budyko theory to quantify the degree of ecohydrological change and its driving factors. Ecological significance indicators (ecosurplus and ecodeficit) and the Shannon index (SI) were used to identify the characteristics of ecohydrological variation and ecological response mechanisms. The results showed the following: (1) The hydrological regime in the Min River basin had an abrupt change in 1993, with the overall alteration degree reaching 44%, which further led to a decrease in ecological surplus and an increase in the ecological deficit in ecological indicators. (2) Budyko's theoretical results show that climate change and human activities together lead to an 83.83 mm reduction in Min River runoff, with human activities contributing 54.20% of the change in the mean annual runoff, while rainfall and evapotranspiration contribute 43.88 and 1.92%, respectively. (3) The SI index indicates a decreasing trend in Min flow biodiversity. The results of the study can provide a reference for enhancing ecological protection and restoration in the Min River basin.
ACORDO DE PARCERIA PARA PESQUISA, DESENVOLVIMENTO E INOVAÇÃO COMO MECANISMO ESTRATÉGICO DE INTERAÇÃO ENTRE A UNIVERSIDADE E AS EMPRESAS
Authors: Azin Diana Guimarães , Carvalho Joelia Marques de , Cavalcante Tarique da Silveira
Published: September 2023

O Marco Legal de Ciência, Tecnologia e Inovação (MLCTI), composto pela EC n. 85/2015, Lei n. 13.243/2016 e Decreto n. 9.283/2018, inaugura um novo regime jurídico no âmbito da ciência, tecnologia e inovação no país, estabelecendo como princípio fundamental a promoção da colaboração e interação entre as entidades públicas, setores público e privado, e empresas, visando impulsionar o sistema nacional de inovação através de uma abordagem cooperativa e sinérgica para avanços científicos e tecnológicos conjuntos. Entre os instrumentos previstos na legislação para o alcance desse objetivo, tem-se o Acordo de Parceria para PDI, que atua como ferramenta estratégica para formalizar e regulamentar a interação entre Instituições Científica, Tecnológica e de Inovação (ICT) e empresas, estimulando a colaboração e a transferência de conhecimento, essenciais para o progresso da inovação no país. Apesar da importância do instrumento jurídico, há desafios na sua aplicação pelas ICT. Desta forma, o objetivo desse trabalho foi apresentar através de uma abordagem análise teórica e da observação participante a relevância do Acordo de Parceria para Pesquisa, Desenvolvimento e Inovação no que se refere à disseminação e à transferência do conhecimento tecnológico impulsionado pelas ICT em direção às empresas. No trabalho foram apresentados os principais aspectos jurídicos e de estruturação do documento, evidenciando sua importância na efetivação da tríplice hélice da inovação.
DESENVOLVIMENTO DE COMPETÊNCIAS DIGITAIS DA EDUCAÇÃO POR INTERMÉDIO DA TRANSFERÊNCIA DE TECNOLOGIA
Authors: Silva Luan Carlos Santos , Lima Valdimeire de Oliveira , Pessoa Débora Luana Ribeiro , Caldeira Rebeca Teles , Zaparoli Dilene
Published: September 2023

Este artigo científico discute a importância da transferência de tecnologia para o desenvolvimento de competências digitais na educação. Com o rápido avanço da tecnologia, é essencial que os educadores e estudantes estejam preparados para lidar com as ferramentas digitais. A transferência de tecnologia pode ajudar a alcançar esse objetivo, permitindo que instituições de ensino tenham acesso a equipamentos e software atualizados. O artigo apresenta um estudo exploratório aplicado para docentes de escolas públicas do ensino fundamental. Os resultados mostraram que a transferência de tecnologia ajudou os professores a aprimorar suas habilidades digitais e também melhorou o engajamento dos docentes em suas aulas. Além disso, o artigo discute a importância da colaboração escolas com os docentes e redes de ensino.  Isso pode ser alcançado por meio de programas de treinamento, suporte técnico e assistência contínua para garantir o uso efetivo da tecnologia em sala de aula. Por fim, o estudo destaca a necessidade de uma mudança na cultura escolar do ensino fundamental para incentivar o uso da tecnologia e aprimorar as habilidades digitais. Os educadores devem se tornar líderes de inovação em suas escolas, criando um ambiente propício para a transferência de tecnologia e o desenvolvimento de competências digitais.
Molecular Subtypes and Prognostic Models for Predicting Prognosis
of Lung Adenocarcinoma based on MiRNA-related Genes
Authors: Wei Yuxi , Zhong Wei , Bi Yalan , Liu Xiaoyan , Zhou Qing , Liu Jia , Wang Mengzhao , Zhang Hong , Chen Minjiang
Published: September 2023

Background:

MicroRNAs (miRNAs) are crucial in cancer development and
progression, and therapies targeting miRNAs demonstrate great therapeutic promise.

Aim:

We sought to predict the prognosis and therapeutic response of lung adenocarcinoma
(LUAD) by classifying molecular subtypes and constructing a prognostic model
based on miRNA-related genes.

Methods:

This study was based on miRNA-mRNA action pairs and ceRNA networks in
the Cancer Genome Atlas (TCGA) database. Three molecular subtypes were determined
based on 64 miRNA-associated target genes identified in the ceRNA network. The S3
subtype had the best prognosis, and the S2 subtype had the worst prognosis. The S2 subtype
had a higher tumor mutational load (TMB) and a lower immune score. The S2 subtype
was more suitable for immunotherapy and sensitive to chemotherapy. The least absolute
shrinkage and selection operator (LASSO) algorithm was performed to determine
eight miRNA-associated target genes for the construction of prognostic models.

Result:

High-risk patients had a poorer prognosis, lower immune score, and lower response
to immunotherapy. Robustness was confirmed in the Gene-Expression Omnibus
(GEO) database cohort (GSE31210, GSE50081, and GSE37745 datasets). Overall, our
study deepened the understanding of the mechanism of miRNA-related target genes in
LUAD and provided new ideas for classification.

Conclusion:

Such miRNA-associated target gene characterization could be useful for
prognostic prediction and contribute to therapeutic decision-making in LUAD.
Butadiene Sulfone-catalyzed Monobromination of Arenes with NBS as
the Bromination Source: A Simple, Mild, Efficient, and Chemoselective
Protocol
Authors: Sharma Amit , Rudrawar Santosh , Jadhav Hemant R.
Published: September 2023

In literature, dimethyl sulfoxide (DMSO) catalyzed bromination of arenes and heteroarenes
is reported. In this study, simple, mild, and chemoselective N-bromosuccinimide (NBS) mediated
monobromination of arenes and heteroarenes using butadiene sulfone as a catalyst is reported.

:

Butadiene sulfone is a good substitute for DMSO as it is volatile, easy to recover and recycle, and environment-
friendly. The method has been demonstrated to give high-yield brominated products for an
extensive range of activated and deactivated arenes.
Omega Invariant of Complement Graphs and Nordhaus-gaddum Type
Results
Authors: Gunes Aysun Yurttas
Published: September 2023

Aims::

To obtain relations between the omega invariants of a graph and its complement.

Background::

We aim to use some graph parameters including the cyclomatic numbers, number of components, maximum number of components, order and size of both graphs G and G. Also we used triangular numbers to obtain our results related to the cyclomatic numbers and omega invariants of G and G.

Objective::

Several bounds for the above graph parameters will be given by direct application of omega invariant.

Methods:

We use combinatorial and graph theoretical methods to study formulae, relations and bounds on the omega invariant, the number of faces and the number of components of all realizations of a given degree sequence. Especially so-called Nordhaus-Gaddum type results in our calculations. In these calculations, the number of triangular numbers less than a given number plays an important role. Quadratic equations and inequalities are intensively used. Several relations between the size and order of the graph have been utilized.

Result::

In this paper, we obtained relations between the omega invariants of a graph and its complement in terms of several graph parameters such as the cyclomatic numbers, number of components,maximum number of components, order and size of G and G and triangular numbers.

Conclusion::

Some relations between the omega invariants of a graph and its complement are obtained.
Identification of Prognostic Markers and Potential Therapeutic Targets
using Gene Expression Profiling and Simulation Studies in Pancreatic
Cancer
Authors: Singh Samvedna , Kaushik Aman Chandra , Gupta Himanshi , Jhinjharia Divya , Sahi Shakti
Published: September 2023

Background:

Pancreatic ductal adenocarcinoma (PDAC) has a 5-year relative survival
rate of less than 10% making it one of the most fatal cancers. A lack of early measures of prognosis,
challenges in molecular targeted therapy, ineffective adjuvant chemotherapy, and strong resistance
to chemotherapy cumulatively make pancreatic cancer challenging to manage

Objective:

The present study aims to enhance understanding of the disease mechanism and its
progression by identifying prognostic biomarkers, potential drug targets, and candidate drugs that
can be used for therapy in pancreatic cancer.

Methods:

Gene expression profiles from the GEO database were analyzed to identify reliable
prognostic markers and potential drug targets. The disease's molecular mechanism and biological
pathways were studied by investigating gene ontologies, KEGG pathways, and survival analysis
to understand the strong prognostic power of key DEGs. FDA-approved anti-cancer drugs were
screened through cell line databases, and docking studies were performed to identify drugs with
high affinity for ARNTL2 and PIK3C2A. Molecular dynamic simulations of drug targets
ARNTL2 and PIK3C2A in their native state and complex with nilotinib were carried out for 100
ns to validate their therapeutic potential in PDAC.

Results:

Differentially expressed genes that are crucial regulators, including SUN1, PSMG3,
PIK3C2A, SCRN1, and TRIAP1, were identified. Nilotinib as a candidate drug was screened using
sensitivity analysis on CCLE and GDSC pancreatic cancer cell lines. Molecular dynamics simulations
revealed the underlying mechanism of the binding of nilotinib with ARNTL2 and PIK3C2A
and the dynamic perturbations. It validated nilotinib as a promising drug for pancreatic cancer.

Conclusion:

This study accounts for prognostic markers, drug targets, and repurposed anti-cancer
drugs to highlight their usefulness for translational research on developing novel therapies. Our
results revealed potential and prospective clinical applications in drug targets ARNTL2, EGFR,
and PI3KC2A for pancreatic cancer therapy.
Targeting Mutant-p53 for Cancer Treatment: Are We There Yet?
Authors: Lim Dhi Vya , Woo Wei Hwei , Lim Jing Xuan , Loh Xin Yee , Soh Hui Ting , Lim Seng Yung Adrian , Lee Zheng Yang , Yow Hui Yin , Hamzah Sharina Binti , Sellappans Renukha , Foo Jhi Biau
Published: September 2023

Background:

Mutations in the TP53 gene are the most common among genetic alterations in human cancers, resulting in the formation of mutant p53 protein (mutp53). Mutp53 promotes proliferation, migration, invasion, and metastasis in cancer cells. Not only does the initiation of oncogenesis ensue due to mutp53, but resistance towards chemotherapy and radiotherapy in cancer cells also occurs. This review aims to summarise and discuss the oncogenesis of mutant p53 in cancer cells and introduce the various mutant p53 inhibitors currently being evaluated at the pre-clinical and clinical stages. Compounds that induce the wild-type conformation on the targeted p53 missense mutation, restore or enhance the DNA binding of mutant p53, and inhibit cancer cells' growth are highlighted. In addition, the progression and development of the mutant p53 inhibitors in clinical trials are updated.

Conclusion:

The progress of developing a cancer treatment that may successfully and efficiently target mutant p53 is on the verge of development. Mutant p53 proteins not only initiate oncogenesis but also cause resistance in cancer cells to certain chemo or radiotherapies, further endorse cancer cell survival and promote migration as well as metastasis of cancerous cells. With this regard, many mutant p53 inhibitors have been developed, some of which are currently being evaluated at the pre-clinical level and have been identified and discussed. To date, APR-246 is the most prominent one that has progressed to the Phase III clinical trial.
Comparison of Ussing Chamber and Caco-2 Model in Evaluation of
Intestinal Absorption Mechanism of Compounds from Different BCS
Classifications
Authors: Tian Dong , Yang Yingxin , Zhang Huiying , Du Hongwen , Zhou Hongyu , Wang Tao
Published: September 2023

Background:

Oral bioavailability (F), which is evaluated by permeability and sol-ubility, is one of the key parameters in drug discovery. Currently, Caco-2 and Ussing cham-ber are both used in the study of intestinal permeability of drugs at different stages of drug development. However, comparative research between the Ussing chamber and Caco-2 for predicting the intestinal availability data (Fa×Fg) in humans has not been reported.

Methods:

In the present study, we evaluated the permeability of 22 drugs in rat intestines by Ussing chamber and compared them with the reported permeability data from Caco-2. In addition, the active transport of gabapentin was evaluated by Ussing Chamber.

Results:

Intestine segments were selected by corresponding absorption site for Ussing cham-ber analysis. BCS Class I and II compounds were more absorbed in the duodenum and jeju-num, and Class III and IV compounds were more absorbed in the ileum. Papp values in the Caco-2 model were moderately correlated with human Fa×Fg (R2=0.722), and the Papp of the rat in the Ussing chamber revealed a better correlation with human Fa×Fg (R2=0.952). In addi-tion, we also used the Ussing chamber to identify the transporter of gabapentin, and the re-sults showed that the active absorption of gabapentin was related to LAT1.

Conclusion:

Ussing chamber combined with rat intestinal tissue would be a significant tool for predicting the intestinal absorption and metabolism of compounds with diverse physio-chemical characteristics.
Permodelan Sumur Resapan Inovatif untuk Konservasi Air Tanah Permeabilitas Rendah Daerah Kota Malang
Authors: Muntaha Yasnuar , Prayogo Tri Budi , Yuliani Emma
Published: September 2023

Air merupakan kebutuhan pokok manusia yang sebagian besar berasal dari dalam tanah. Konservasi air tanah menggunakan sumur resapan merupakan alternatif dalam menambah cadangan air tanah pada tanah berjenis lanau-lempung seperti Kota Malang yang memiliki permeabilitas tanah rendah. Dalam mencapai tujuan tersebut dilakukan penelitian dengan metode eksperimen pembuatan sumur resapan inovatif yang dapat memaksimalkan masuknya air ke dalam tanah pada lokasi yang mempunyai permeabilitas rendah. Penelitian ini mengkaji, menganalisa dan membandingkan hasil pengujian sumur resapan konvensional dan inovatif. Analisis debit yang dirancang menggunakan Metode Rasional. Perencanaan dimensi dihitung dengan rumus Sunjoto dan desain serta model sumur resapan yang dibuat menggunakan material paving, pasir, semen, kerikil, pipa diameter 10 cm, penutup biopori, sampah organik, air, dan geotekstile. Model sumur resapan inovatif direncanakan dengan ketinggian 0,42 m dengan diameter 0,6 m. Dari hasil analisa pengujian model sumur resapan yang sudah di terapkan dalam skala lapangan, sumur resapan inovatif lebih efektif dari pada sumur resapan konvensional.
Concept and Content of Pardon and Apologize in Language
Authors: Brzo Omed Barzan , Ghaidan Layla Aziz
Published: September 2023

This research is entitled (Concept and Content of Pardon and Apologize inLanguage), the research is an attempt to show how to apologize and justificationin language, the content of the research consists of three topics In the HolyScriptures, the strategies of apology and how the action is done according to themistakes, or crimes. The second topic discusses the concepts, origins, laws andtypes of justification. The third topic discusses the reasons for the success of theact of forgiveness and justification, and finally the results and a list of sources arediscussed.
Research on the Assessment Approaches to Pronunciation Training for Pre-Service EFL Teachers
Authors: Li Muyun
Published: September 2023

For EFL teacher education, it’s important to polish pre-service teachers’ pronunciation and their pronunciation teaching skills. Currently, the pronunciation training for pre-service EFL teachers in China only focuses on pronunciation improvement and lacks the element of teacher education so that its efficacy still needs improvement. This paper points out the rationale of applying the Learning-Oriented Assessment (LOA) to the pronunciation training for pre-service EFL teachers. Then the author discusses the evaluation approaches integrating assessment of learning, assessment as learning and assessment for learning after reformulating the goals of the pronunciation training for pre-service EFL teachers. Finally, the author analyzes the effectiveness of the evaluation approaches for improving pre-service English teachers’ pronunciation as well as their pronunciation teaching skills.
Preparing for College and Graduate School
Authors: Nemeth Andrea , Shamirian Tatiana , Schultz Maseri Kisa , Hogue Cheryl Courtney , Zavala Maria Elena , Giacopuzzi Rachel , Oppenheimer Steven
Published: September 2023

We know of no single programs that prepare students both for success in college and entry to graduate school. Here we will describe a 5- week summer program that attempts to do that.This 5- week summer program helps students with Math, Writing and gives them access to information on graduate schools and research as a career. We recruit primarily underrepresented or economically disadvantaged (Pell eligible) entering freshmen science students (likely science majors) using a rigorous application form that includes high school transcripts, letter of recommendation and an essay. For success in improving academic skills, motivation is key. That’s why we carefully and rigorously evaluate all candidates for this program. And that’s why we can claim some success.For science majors, Math is critical. So let’s begin with describing our Math program, which runs 3 days a week, for 5 weeks, all day, usually Mon, Tues and Fri.
The Innovation and Practice of Synergistic Cultivation Model of Integrating the Spirit of Volunteer Teaching in Western China into the Moral Education of College English
Authors: Fu Huijun , Li Feipeng
Published: September 2023

Volunteer teaching in western China is an important initiative to serve the development of the western region of the country and contribute to the talent and science education of the west region. As a distinctive culture of Baoding University, volunteer teaching in western China is rich in educational values. Based on College English course, this paper mainly discusses the current dilemmas of the moral education of this course, puts forward synergistic cultivation strategies of integrating the spirit of volunteer teaching in western China into the moral education of College English, and presents some preliminary achievements of the synergistic cultivation model. It is expected that this research will promote the combination of college English teaching and patriotic education, realize the fundamental task of fostering virtue through education, and increase the output of volunteer teaching talents.
Analysis of distortion, corrosion and mechanical properties of welded ASTM A36 steel U-type profiles
Authors: Pereira Josemairon Prado , Hernandez Bruno Agostinho , Gonçalves Gilberto de Magalhães Bento , Sousa Edson Antonio Capello , Pereira Jonatas Martins
Published: September 2023

Several factors affect the performance, manufacturing, and assembly of metallic profiles: equipment, welding parameters, and consumables. ASTM A36 steel profiles are widely used to obtain high-quality welded joints. Three factors in the welded joints need to remain nearly invariable and within predictable limits: distortion, corrosion, and mechanical properties. However, industries still have problems with welding steel profiles, such as warping misalignment, misfit, and poor mechanical properties. As a result, it is necessary a calibrated and affordable methodology for welding ASTM A36 steel profiles on the factory floor. Therefore, this study aims to analyse the mechanical performance of ASTM A36 steel profile welded joints using a robot welding machine. A GMAW (Metal Active Gas) welding process was applied to an ASTM A36 type U 100 x 50 profile, 3.0 mm thick, employing a Motoman UP6 robotic arm in butt joints, with and without dots. Two different rod electrode types were used (AWS ER70S-3 and ER70S-6), with a 75%Ar/25%CO2 shielding gas and current density welding set at 160.6 A and 20.5 V. A three-dimensional scanning methodology was adopted to investigate welded joint distortions. While salt spray accelerated corrosion test was used to analyse deterioration. The mechanical properties were analysed by macrography, microhardness, and chemical analyses in the Heat Affected Zone (HAZ). It was found a distortion displacement lower than 450 µm on the sample's surface, and a mass loss of 10.1 µm/year was detected in terms of corrosion resistance. There was also evidence of chemical heterogeneity between the base metal and weld, mainly in the manganese content with an average reduction of 13% in microhardness measurements when AWS ER70S-3 electrode was used. By using calibrated welding parameters and a welding robot, it was possible to obtain mechanically resistant high-quality standardised welds. This procedure can be further improved by using other profile types to implement new robotic welding procedures.
Beef Cattle Farmers’ Economic Behavior in the Minahasa Tenggara Regency, Indonesia
Authors: Wantasen Erwin , Umboh Sintya JK , Leke Jein R
Published: September 2023

The purpose of this research is to analyze the influencing factors of household income from beef cattle business in the use of artificial insemination and natural mating and evaluate the impact of changes in various external factors on economic behavior, such as the added value of cattle, income from cattle and production costs, allocation of family labor, the income of food crop farming, family income, food consumption, and non-food consumption as well as farmer household savings in the use of artificial insemination and natural mating systems in beef cattle. Further, the measurement of insemination and natural mating employed the approach of inseminator and natural mating costs. This research was conducted using a case study method on 150 beef cattle farmers located in Tababo Selatan Village and Buku Selatan Village, Belang District and Molompar Village and Molompar I Village, Tombatu Timur District, Minahasa Tenggara Regency. Specifically, the study used a purposive random sampling method. Data were analyzed by simultaneous equations, using the two-stage least squares (2 SLS) method and simulated analysis, using the SAS statistical application program. The results show that artificial insemination and natural mating systems had a significant effect on the added value of cattle, increasing the family time allocation of the farmer to the cattle business, production costs, the value of manure production, the rent value of bulls, and the value of unsold cattle. The simulation model demonstrated that an increase in inseminator costs and natural mating costs by 20% could increase the added value of beef cattle, allocation of family working time in the cattle business, beef cattle income, family income of the farmers, and food and non-food consumption.
Studies on chemical, physical and microbiological quality characteristics of Barki sheep burger fed on medicinal plants with yeast
Authors: Zaki Engy Fayz , Ghandour Moustafa Mohamed M.A.
Published: September 2023

The current study aimed to evaluate the effect of dietary supplementation of medicinal plants with yeast on the fatty acid profile, chemical, physical and microbiological quality of Barki sheep burger during frozen storage at -20 °C for 90 days. Fifteen Barki lambs (13.46 ± 3.47 kg body weight, 4.5 months of age) were randomly divided into three groups (5 lamb/group). T1: control group fed on berseem hay and concentrate feed mixture. T2: fed on control diet + air dried powder of medicinal plants mixture which consisted of (garlic, cumin, ginger and turmeric). T3: fed as group two with (Saccharomyces cerevisiae). Results indicated that addition of yeast to medicinal plants significantly decreased (p<0.05) palmitic acid, myristic acid and increased the content of oleic acid and decatrienoic acid with non-significant effect on linoleic acid and α linolenic acid. Burger of medicinal plants with yeast group had the lowest index of atherogenicity (IA) which is healthier for human consumption. Feeding type had a slight significant effect on pH values of fresh sheep burger. No significant differences were found in shear force values of sheep burger. Cooking loss of sheep burger processed from sheep fed on medicinal plants recorded the lowest cooking loss, followed by sheep burger of medicinal plants with yeast. Burger of medicinal plants group showed the lowest TBA value. Feeding types and storage conditions significantly (p<0.05) affected on color parameters (L*, a* and b*). No significant changes in microbiological quality of sheep burger during frozen storage. In conclusion, sheep burger processed from lambs fed on diet supplemented with medicinal plants and yeast improved the composition of fatty acids, delayed the lipid oxidation and decreased the cooking loss without any negative effects on color parameters, shear force and microbial analysis which is subsequently affected on sheep burger quality and human health.
Analysis of Factors Affecting the Growth and Development of Maize Crops (Zea Mays L) in Adiankoting Sipoholon and Paranginan Districts
Authors: Panjaitan Nixson , Simangunsong Saudur , Simatupang Lambok , Purba Weslyh
Published: September 2023

This study aims to determine the factors that affect the growth and development of corn plants (zea mays l.) in the sub-districts of Adiankoting, Sipoholon and Paranginan. This study uses the Statistical Package Social Sciences (SPSS) stastika formula consisting of each sub-district using 50 questionnaires from Adiankoting sub-district 50 questionnaires, from Sipoholon sub-district 50 questionnaires and from Paranginan sub-district 50 questionnaires, and the total amount to 150 questionnaires. This research was conducted by a direct field survey system and interviews with respondents or corn farmers in each of the 150 farmers, the results of this study indicate that in each sub-district there are different and some are the same in terms of altitude, land area, planting distance, age of farmers and others. The three sub-districts are dominated by male farmers, mostly only diparanginan more female farmers but maybe in other areas or in other villages there may also be many female farmers. I conducted this research during October to November 2021 where there is still strict health protocol supervision because corona has spread everywhere, so caution is needed. In the Adiankoting, Sipoholon and Paranginan sub-districts, the various types of fertilizers used and the way they are applied and pests and diseases are too many to attack in these areas.
Transmission Electron Microscopic (TEM) analysis of STZ-diabetes induced Cardiac Structural changes in Rats.
Authors: Manikandhan C , Daniel Vivek , Daniel Kratika
Published: September 2023

Diabetes mellitus (DM) is a global health crisis, imposing a substantial burden on both healthcare systems and individuals due to its chronic nature and associated complications. Among these complications, cardiovascular diseases rank as the primary cause of morbidity and mortality in people with diabetes. Diabetic cardiomyopathy (DCM), a distinctive form of heart disease, is characterized by structural and functional abnormalities within the heart, independent of conventional cardiovascular risk factors. The multifaceted pathophysiology of DCM involves factors like hyperglycemia-induced oxidative stress, inflammation, altered myocardial metabolism, and fibrosis, collectively leading to cardiac tissue structural changes and impaired function. Streptozotocin (STZ), a compound derived from Streptomyces achromogenes, is commonly used to induce diabetes in animal models, particularly rodents, making it a valuable tool for simulating diabetes in laboratory settings. Transmission Electron Microscopy (TEM) provides a powerful means to investigate ultrastructural changes within cardiac tissues at the microscopic level, encompassing myofibrillar structure, mitochondrial integrity, sarcoplasmic reticulum, and interstitial components. Figure-1 illustrates the pathological changes caused by STZ-induced diabetes in experimental animals, showing structural alterations in cardiac and brain tissues. Notably, the use of a polyherbal extract containing Curcuma amada rhizome and Sida spinosa leaves appears to mitigate some of the detrimental effects of STZ-induced diabetes on cardiac cells, suggesting potential protective benefits.
A Study of Construct Validity of English Language Reading Test of Secondary School Certificate (SSC) Examination in Bangladesh
Authors: Halder Joyanty
Published: September 2023

The aim of this study was to investigate the construct validity of the English Language reading test of secondary school certificate examination in Bangladesh. A qualitative research method was incorporated to collect and analyze the data followed by a retrospective and introspective interview. For conducting the research, the eight SSC candidates of session 2021-2022 and three teaching and testing experts were invited. The students were asked to participate in an instant English reading test and the experts were invited to make judgments on three reading strategies and students’ reading performances. The study found a little agreement among specified reading strategies of secondary education curriculum, experts’ judgments and students’ used reading strategies for establishing the construct validity of the English reading test of secondary school certificate examination in Bangladesh.
ECONOMIC IMPACT OF COVID-19 ON THE EUROPEAN AIRLINE INDUSTRY
Authors: Stanojević Jelena , Mitić Gabrijela , Radivojević Vladimir
Published: September 2023

Business entities from various industries are facing significant challenges since the COVID-19 pandemic outbreak. The airline industry, along with travel, tourism and hospitality, have been the worst affected economic sectors during the coronavirus health crisis. The paper analyzes the economic impact of COVID-19 on the European airline industry. The research is made by measuring the liquidity and profitability of five leading European airline companies before and after the pandemic outbreak (in the period from 2015 to 2020). The aim is to determine the extent of the health crisis consequences on the financial results of the five European companies with the largest number of passengers in 2019. The research is conducted through financial statement analysis and descriptive statistics. The results show that the COVID-19 pandemic had a significantly more detrimental effect on profitability compared to the liquidity of European airlines.
A Comprehensive Research Study on Cloud Security
Authors: Bhatt Devanshi , Desai Ishika , Parekh Kunal
Published: September 2023

Abstract: With the aid of a significant quantity of virtual storage, cloud computing delivers on-demand services through the Internet. The key advantages of cloud computing are that the customer does not need to build up costly computer equipment and that the cost of its services is lower. Cloud computing has been integrating with the industry and many other fields in recent years, which has encouraged researchers to do research on new related technologies. Individual users and enterprises migrate their applications, data, and services to the cloud storage server due to the availability of its services and scalability for computing activities. Regardless of its benefits, the shift from local to remote computing has created a slew of security risks and hurdles for both consumers and providers. Many cloud services are delivered by a trusted third party, posing additional security risks. The cloud provider offers its services through the Internet and employs several online technologies, which raise new security concerns. This article explored the fundamentals of cloud computing, as well as security concerns, threats, and solutions. Furthermore, the article discusses various essential cloud themes, such as the cloud architectural framework, service and deployment model, cloud technologies, cloud security ideas, threats, and assaults. The report also highlights a number of outstanding research challenges concerning cloud security.
Performance and Economical Analysis of Solar Roof Plant with and without Reflectors
Authors: Singh Punit Kumar , Agrawal Amit
Published: September 2023

Abstract: This thesis aims to explore the feasibility and potential benefits of implementing a solar roof plant in Gwalior, Madhya Pradesh. The escalating demand for energy, coupled with the urgent need to reduce greenhouse gas emissions, calls for innovative and sustainable solutions. Solar energy has emerged as a viable alternative to conventional power sources, offering significant environmental and economic advantages. This research focuses on Gwalior, a city with abundant sunlight and ample roof space, making it an ideal candidate for solar energy harnessing. The study begins with a comprehensive assessment of the current energy scenario in Gwalior, analyzing the energy consumption patterns and the existing power infrastructure. This analysis establishes a baseline for evaluating the impact and potential of a solar roof plant in the region. Key areas of investigation include the technical feasibility of installing solar panels on rooftops, the economic viability of the project, and the environmental benefits it would bring. The thesis also addresses the regulatory framework and policy support necessary to encourage solar power adoption in Gwalior. Key stakeholders, such as government bodies, utility companies, and local communities, will be involved in the research process to ensure a holistic approach. By utilizing advanced simulation tools and data analysis techniques, this thesis will quantify the energy generation potential of a solar roof plant in Gwalior. Factors such as solar irradiance, panel efficiency, and rooftop suitability will be considered to determine the optimal configuration and capacity of the plant. Furthermore, financial models will be developed to assess the return on investment and the long-term cost-effectiveness of the project. The findings of this study are expected to demonstrate the significant advantages of a solar roof plant in Gwalior. These advantages include reduced reliance on fossil fuels, decreased carbon emissions, and improved energy security. The research outcomes will contribute to the body of knowledge on solar energy implementation and serve as a valuable reference for policymakers, urban planners, and renewable energy enthusiasts.
Inclusion of deuterated glycopeptides provides increased sequence coverage in hydrogen/deuterium exchange mass spectrometry analysis of SARS-CoV-2 spike glycoprotein
Authors: Haynes Christopher A. , Keppel Theodore R. , Mekonnen Betlehem , Osman Sarah H. , Zhou Yu , Woolfitt Adrian R. , Baudys Jakub , Barr John R. , Wang D
Published: September 2023

Rationale. Hydrogen/deuterium exchange mass spectrometry
(HDX-MS) can provide precise analysis of a protein’s conformational
dynamics across varied states, such as heat-denatured vs. native protein
structures, localizing regions that are specifically affected by such
conditional changes. Maximizing protein sequence coverage provides high
confidence that regions of interest were located by HDX-MS, but one
challenge for complete sequence coverage is N-glycosylation sites. The
deuteration of peptides post-translationally modified by
asparagine-bound glycans (glycopeptides) has not always been identified
in previous reports of HDX-MS analyses, causing significant sequence
coverage gaps in heavily glycosylated proteins and uncertainty in
structural dynamics in many regions throughout a glycoprotein.
Methods. We detected deuterated glycopeptides with a Tribrid
Orbitrap Eclipse mass spectrometer performing data-dependent
acquisition. An MS scan was used to identify precursor ions, if
high-energy collision-induced dissociation (HCD) MS/MS of the precursor
indicated oxonium ions diagnostic for complex glycans then electron
transfer low-energy collision-induced dissociation (EThcD) MS/MS scans
of the precursor identified the modified asparagine residue and the
glycan’s mass. As in traditional HDX-MS the identified glycopeptides
were then analyzed at the MS level in samples labeled with D
O. Results. We report HDX-MS analysis of the
SARS-CoV-2 spike protein ectodomain in its trimeric pre-fusion form,
which has 22 predicted N-glycosylation sites per monomer, with and
without heat treatment. We identified glycopeptides and calculated their
average isotopic mass shifts from deuteration. Inclusion of the
deuterated glycopeptides increased sequence coverage of spike ectodomain
from 76% to 84%, demonstrated that glycopeptides had been deuterated,
and improved confidence in results localizing structural
re-arrangements. Conclusion. Inclusion of deuterated
glycopeptides improves the analysis of the conformational dynamics of
glycoproteins such as viral surface antigens and cellular receptors.
Predicting Fast Visual Discrimination Through Slow Theta Oscillation of Visual ERPs
Authors: Ma Zhaonan , Wang Xiaoyu , Astikainen Piia , Hämäläinen Timo , Cong Fengyu
Published: September 2023

In the context of sensory processing, visual discrimination is a
fundamental function that enables survival. Previous findings suggest
that such discrimination function can be decoded from
electroencephalographic brain responses, especially by using oscillation
feature. However, how to evaluate the fast visual discrimination is
still unclear. In this study, we hypothesize that brain’s oscillatory
activity in a passive viewing condition can serve as a sensitive
predictor of fast visual discrimination. A visual multi-feature paradigm
which allowing investigation of several different change types was used
to record both event-related potentials (ERPs) and behavioral responses.
First, we investigated separating the behavioral hit rate as a function
of reaction time (categorized from 200 ms to 1000 ms with step of 100
ms). In the subsequent step, we extract the slow theta component from
ERP’s time frequency represents with time frequency principal component
analysis (TF-PCA) and correlate its average power with behavioral
performance. Our results showed that the significant detect window for
different deviants’ level was from 400 to 600 ms, while the hit rates in
such detect window showed a significant correlation with the averaged
time frequency power in the slow theta band during 100-300 ms latency
for the color and shape deviants. These findings suggest that the
oscillation power, particularly in the slow theta range, of the brain
responses is a predictor of fast visual discrimination.