bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethos da riqueza
Authors: Moraes Érika de
Published: November 2019

O artigo desenvolve uma reflexão sobre o ethos discursivo construído (e em construção) por Nathalia Arcuri em seu canal do YouTube, Me Poupe!. Com respaldo no quadro teórico-metodológico da Análise do Discurso francesa, as análises de três vídeos buscam compreender os dispositivos de enunciação que tornam possível a emergência de discursos que legitimam a imagem da especialista em finanças. É destacado o conceito de ethos discursivo, conforme reelaborado por Maingueneau, revelador do caráter e corporalidade que moldam os discursos na mesma intensidade que os “conteúdos” que estes veiculam. O ethos da educadora de pulso firme, guerreira e elaboradora de autoestima sinaliza a construção de uma subjetividade forte, tratada aqui em sua complexidade.
As pin-ups contemporâneas
Authors: Lara Glaucia Muniz Proença , Gomes Tânia Maria de Oliveira
Published: November 2019

À luz da análise do discurso francesa, na sua interlocução com um referencial teórico ligado, mais especificamente, à moda, analisamos, no presente artigo, produções discursivas extraídas de blogs atuais com temática retrô que foram criados por mulheres brasileiras, a fim de apreender como se elaboram os éthe daquelas que, na contemporaneidade, autodenominam-se “pin-ups modernas”. Por meio do exame dos discursos manifestados em seus blogs, conseguimos vislumbrar pontos de contato e de distanciamento entre as construções ethóticas que elas promovem. Assim, se a referência ao universo retrô é aquilo que as une, cada uma homenageia o passado a partir do bojo de suas vivências, projetando uma imagem singular. Este estudo nos permitiu, portanto, constatar a eficiência da noção de éthos como instrumento de análise capaz de deslindar o universo cultural retrô imbricado nos dizeres das blogueiras.
Notas sobre competição e bloqueio de afixos
Authors: Resende Maurício Sartori
Published: November 2019

Este artigo explora fenômenos morfológicos e semânticos que subjazem à sufixação, com ênfase na formação de nominalizações eventivas do português à luz dos pressupostos da Morfologia Distribuída (HALLE & MARANTZ, 1993). Primeiramente, este estudo discute o estatuto da sufixação como processo geral de formação de palavras que envolve mudança de classe em português e levanta questões a respeito das motivações para o grande repertório de sufixos nominalizadores do PB. Em seguida, o presente trabalho mostra que, pelo menos, um subconjunto dos sufixos nominalizadores produz algum efeito semântico sobre a raiz/estrutura com que se combina, mas que tal contribuição semântica não deve ser confundida com aspecto, como defendem alguns autores. Por fim, este artigo tece algumas considerações sobre a melhor forma de o sistema acomodar a ocorrência de diferentes sufixos, tanto com motivações semânticas quanto puramente morfológicas.
Editorial
Authors: Mello Paulo Eduardo Dias de
Published: November 2019

Editorial
Special Issue on Advanced Abrasive Process Technologies
Authors: Suzuki Hirofumi , Ohashi Kazuhito
Published: November 2019

The demand for high-precision and high-efficiency machining of hard ceramics such as silicon carbide (SiC) for semiconductors and hardened steel for molding dies has significantly increased for power devices in automobiles, optical devices, and medical devices. Certain types of hard metals can be machined by deterministic precision-cutting processes. However, hard and brittle ceramics, hardened steel for molds, or semiconductor materials have to be machined by precision abrasive technologies such as grinding, polishing, and ultrasonic vibration technologies with diamond super abrasives. The machining of high-precision components and their molds/dies by abrasive processes is much more difficult owing to their complex and nondeterministic nature as well as their complex textured surface. Furthermore, high-energy processes with UV lasers and IR lasers, and ultrasonic vibration can be used to assist abrasive technologies for greater precision and efficiency. In this sense, precision grinding and polishing processes are primarily used to generate high-quality and functional components usually made of hard and brittle materials. The surface quality achieved by precision grinding and polishing processes becomes more important to reduce processing time and costs.

This special issue features seven research papers on the most recent advances in precision abrasive technologies for hard materials. These papers cover various abrasive machining processes such as grinding, polishing, ultrasonic-assisted grinding, and laser-assisted technologies.

We deeply appreciate the careful work of all the authors and thank the reviewers for their incisive efforts. We also hope that this special issue will encourage further research on abrasive technologies.
Effects of Blade Tip Profile on In-Plane Tensile Properties of Wedge-Notched Polypropylene Sheet
Authors: Nagasawa Shigeru , Yamamoto Akihiro , Ruchirabha Thepwachara , Umemoto Kazuki ,   Department of Mechanical Engineering, Nagaoka University of Technology 1603-1 Kamitomioka, Nagaoka, Niigata 940-2188, Japan,   FANUC Corporation, Oshino-mura, Japan
Published: November 2019

In this work, the tensile characteristics of a 0.2-mm-thick polypropylene (PP) sheet subjected to indentation with virgin and blunt knives (apex angle, α=42◦; tip thickness, w=6 and 20 μm, respectively), were experimentally investigated. To determine the effect of mechanical condition, such as the notched depth and the profile of the root surface, on the breaking behavior of the half-cut PP specimen, the tensile testing of the half-cut specimen was carried out by varying the indentation depth and tensile velocity. By the experiments, the breakage behavior of the scored (half-cut) zone was determined by varying the indentation depth, tip thickness of the blade, and elongation rate. A kind of crazing or cracking by the blunt knife decreased the tensile resistance and burr elongation for an indentation depth larger than 0.9, whereas the work hardening by the blunt knife increased these properties for an indentation depth less than 0.8. When a blunt knife was used at a high elongation rate larger than 0.01 s-1, the half-cut zone of the PP sheet exhibited brittle fracture, i.e., the tensile resistance and burr elongation decreased.
Influencia de la ansiedad de los padres y niños antes de la primera visita odontológica
Authors: Meza Orihuela Jackeline , Cárdenas Flores Carol
Published: November 2019

Objetivo: Determinar la relación entre la ansiedad al tratamiento odontológico de los padres y la del niñode 2 a 5 años en la primera visita odontológica en el puesto de salud del distrito de Huaricolca, provinciade Tarma.Metodología: Estudio descriptivo correlacional, se realizó con 63 padres de familia con sus respectivosniños que utilizaron los servicios odontológicos. Las técnicas utilizadas incluyeron la entrevista con la Escalade Ansiedad Dental del Corah (EAD) que va dirigida a los padres, la cual ya se encuentra estandarizada yvalidada, y la técnica de observación en la toma de la presión arterial con el oxímetro de pulso en los niñosde 2 a 5 años, ambas fueron aplicadas antes de la primera visita odontológica.Conclusiones: Existe correlación en la ansiedad del padre y el niño antes de la primera visita odontológica.
Frenectomía: .abordaje transdisciplinario
Authors: Fournier Romero, Catherine
Published: November 2019

El propósito de este trabajo es presentar un protocolo de atención de frenectomía para una atención temprana de las alteraciones de la lengua en niños. El enfoque transdisciplinario involucra la participación en conjunto de dos o más profesionales en un mismo espacio terapéutico, enriqueciendo el abordaje. Requiere del compromiso de todos los profesionales, incluidos los cuidadores. En la práctica clínica, observamos la necesidad de contar con fonoaudiólogas y odontopediatras que conjuntamente realicen la detección de alteraciones en las funciones del sistema estomatognático. De esta manera, se realiza el abordaje eficiente de la frenectomía, considerando los procedimientos pre y posquirúrgicos. El propósito de este artículo es proponer un protocolo del área para la atención en la fase prequirúrgico y posquirúrgico de la cirugía del frenillo lingual en pacientes odontopediátricos.
Impacto de la lactancia no materna en el infante
Authors: Jara Porroa Jackeline Jajaira , Montalvo Castillo Sandra Catherine , Romero González María Alejandra , Ticse Tovar Jéssica
Published: November 2019

Objetivo: La lactancia materna ha sido la principal fuente de alimentación desde el nacimiento del serhumano, siendo recomendada por la Organización Mundial de la Salud como alimento exclusivo durantelos seis primeros meses de vida; sin embargo, por diversas causas se ha ido reemplazando por fórmulaslácteas u otros tipos de leche artificial, al cual se le ha denominado lactancia no materna. Este tipo dealimentación se da principalmente a través del uso del biberón proporcionando ventajas y desventajastanto a los padres como al infante. El uso de estas fórmulas lácteas es de acuerdo a la etapa de vida en la quese encuentra el infante y debe ser orientado por un profesional; por otro lado, si este tipo de alimentaciónno es acompañada con la adecuada higiene oral, se prolonga y se da con mucha frecuencia, se convierteen un factor predisponente a la aparición de caries de infancia temprana, hábitos nocivos, etc.Por lo tanto, el objetivo del presente artículo de revisión es proporcionar información actualizada sobre lalactancia no materna y sus implicancias a nivel de la cavidad bucal.
Alternativa estética y funcional del sector anterior en dentición decidua
Authors: Alarcón Calle Catherine Sharlot , Perona Miguel de Priego Guido , Mock Ferreyros Augusto
Published: November 2019

El tratamiento odontológico del niño con dentición decidua tiene como fin la  preservación e integridad de la cavidad oral. Son muchas las causas que desencadenan la ausencia dentaria. La pérdida prematura de manera individual o múltiple puede generar trastornos como: limitación en funciones básicas,  disminución de la longitud de los arcos dentarios, aparición de hábitos incorrectos y llegar al punto de disminuir la autoestima del niño. La  prótesis  fija con bandas ortodóncicas es una opción para obtener un recurso funcional y estético en niños que  son poco colaboradores para usa aparatos removibles. El presente caso tuvo como objetivo preservar el tejido de sostén y mucosa oral; para que de esa manera las funciones de masticación, deglución y fonación no se vean alteradas; proveer una estética armónica dentofacial lo cual evitará la extrusión de los dientes antagonistas al espacio edéntulo y recuperar la autoestima perdida
¿Tratamiento o procedimiento dental?
Authors: Otero Injoque Jaime
Published: November 2019

Objetivo: Se describen diferentes motivos para utilizar correctamente el término tratamiento dental, diferenciándolo del concepto de procedimiento dental. Para ello, se detallan distintas implicancias que afectan los resultados de la práctica dental cuando se da preponderancia solo al componente procedimental de la terapia odontológica.
Convergencia de lo onírico y lo alegórico en la narrativa de Manuel Scorza
Authors: Grillo María Teresa
Published: November 2019

En su obra novelística, el autor peruano Manuel Scorza hace uso de la fantasía y el mito para representar los conflictos entre los campesinos de los Andes peruanos, y los terratenientes, empresas mineras y autoridades. Como uno de sus recursos narrativos, el escritor reviste de características sobrenaturales a sus protagonistas, y abre un espacio onírico en que resulta posible concebir la posibilidad de derrota de los opresores, espacio que es clausurado violentamente por los desenlaces trágicos que culminan en la masacre de los campesinos. Además de inscribirse en un espacio textual onírico, los dones sobrenaturales metaforizan la esperanza de un pueblo, y permiten apreciar la dimensión alegórica de los personajes centrales.
Los universos opuestos en El camino de regreso, de José de Piérola
Authors: Vargas Yábar Miguel
Published: November 2019

La novela El camino de regreso (2007) visibiliza el complejo y conflictivo entramado social de nuestra nación, donde las normas y las leyes operan de manera distinta en función de la raza, la clase social y el lugar de origen de los ciudadanos. La relación conflictiva entre los personajes centrales sirve como metáfora del fratricidio entre compatriotas. El conflicto armado interno conmociona a la nación, pero no afecta de la misma manera a todos sus ciudadanos. A través de sólidos y complejos personajes, la novela realiza una fuerte crítica a las estructuras que posibilitaron el conflicto armado, pero también anuncia épocas de cambio y desarreglos del statu quo. Por ello, en el presente ensayo propondremos que, en la novela, las clases populares, históricamente marginadas y las clases dirigentes, tradicionalmente irresponsables e injustas, finalmente enfrentan cambios de paradigmas sociales. El camino de regreso da cuenta de un nuevo paradigma que busca solucionar problemas, históricamente irreconciliables, a través de personajes de distintas clases sociales que comparten su interés por el progreso, la legalidad y la protección de las mayorías. La novela, desde un registro realista, aporta nuevas significaciones con respecto a lo acontecido a través de las experiencias de distintos actores sociales, por lo que puede afirmarse que están insertos en un proceso literario de verdad que muestra una toma de conciencia por parte del autor respecto del mundo representado y reflexiona sobre las coordenadas sociales y culturales producto del conflicto, posibilitando la revisión crítica de las mismas.
Las competencias del docente de posgrado: un estudio comparativo en cuatro maestrías especializadas desde la percepción de los estudiantes
Authors: Valcazar Montenegro Edy Esther
Published: November 2019

El presente estudio tuvo el propósito de probar que existen diferencias significativas al comparar los niveles de evaluación de las competencias del docente desde la percepción de los estudiantes de las cuatro maestrías especializadas de CENTRUM PUCP en Lima. La investigación fue de tipo aplicada, con diseño no experimental, descriptivo comparativo, de método hipotético-deductivo y cuantitativo. La muestra fue de 143 estudiantes de cuatro maestrías especializadas, elegidos aleatoriamente. Se compiló información por encuesta, mediante la elaboración de un cuestionario con 30 ítems para las competencias del docente. Se hizo inferencia mediante el estadístico Kruskal-Wallis, p-valor < 0,01, por el cual se probó estadísticamente la hipótesis general, y se concluyó que existen diferencias significativas al comparar los niveles de evaluación de las competencias del docente desde la percepción de los estudiantes de las cuatro maestrías especializadas.
"Un tal Scorza empieza a meterse en camisa de once varas": la posición ambigua del narrador en La guerra silenciosa
Authors: Polo Taboada Marco
Published: November 2019

A partir de los planteamientos de Antonio Cornejo Polar sobre el sujeto y el discurso migrantes, en este artículo se analiza la inestabilidad del narrador de Redoble por Rancas y la autofiguración del autor en La tumba del relámpago, la primera y la última novela del ciclo narrativo La guerra silenciosa del peruano Manuel Scorza. El escrutinio de ambas estrategias narrativas permitirá evidenciar, al mismo tiempo, la inoperatividad de las categorías habituales mediante las que se ha interpretado a la pentalogía y el complejo y múltiple andamiaje discursivo a través del cual el autor desea estrechar la distancia entre la realidad referida y su representación textual.
Optimizing Acid Fracture Design in Calcite Formations: Guidelines Using a Fully Integrated Model
Authors: Aljawad Murtada Saleh , Palharini Schwalbert Mateus , Zhu Ding , Hill Alfred Daniel
Published: November 2019

The performance of acid-fractured wells depends on the conductivity distribution along the acid-penetration length, which is a function of reservoir properties, treatment design, and execution. The previously published models for fractured-well performance assume constant fracture conductivity, which cannot be achieved in acid-fracturing operations. This work proposes a design optimization method where acid-fracture and reservoir models are integrated. Fracture-conductivity distribution along the fracture surface is considered in the optimization process.

In the new integrated model, the acid transport and reaction are joined to the fracture-propagation and heat-transfer models. The dissolution patterns along fracture surfaces are generated, and this is converted to a conductivity distribution. To predict the fractured-well productivity, the reservoir model is built using the input reservoir properties, as well as the calculated acid-fracture geometry and conductivity distribution. The acid-fracturing parameters that lead to the optimal fracture productivity are determined with this integrated model.

This method shows that there is an optimal productivity that can be obtained for a given acid treatment volume and reservoir properties. Design parameters such as flow rate, viscosity, acid concentration, acid treatment volume, and pad and overflush volumes can be selected to achieve optimal well performance. Reservoir permeability has an important impact on how acid-fracture jobs should be designed. At low-reservoir permeability, a more evenly distributed conductivity and a long acid-penetration length are preferred. This can be accomplished by injecting a retarded acid system at moderate- to high-flow rate. However, excessive fracture-height growth should be prevented by carefully designing the injection rate and viscosity. For high-permeability reservoirs, higher conductivity along a shorter acid-penetration length is targeted. This can be obtained by selecting a more-reactive acid system such as straight acid and injecting at moderate rates, or by lowering the injection rate of retarded acids. A minimum amount of pad should be used in this case. Still, the flow rate should be highly sufficient to keep the fracture open during acid injection. We also show how acid concentration and fluid stages can be designed to optimize productivity and presents a procedure for selecting the acid treatment volume.

A theoretical model, which integrates acid fracturing and reservoir flow, is used to implement the guidelines on optimizing acid-fracture design parameters. In this paper we provide a scientific approach to determine acid treatment volume that yields optimal outcomes for acid fracturing.
Genome-wide comparative analysis of the BAHD superfamily in seven Rosaceae species and expression analysis in pear (Pyrus☓ bretschneideri)
Authors: Liu Chunxin , Qiao Xin , Li Qionghou , Zeng Weiwei , Wei Shuwei , Wang Xin , Chen Yangyang , Wu Xiao , Wu Jun , Yin Hao , Zhang Shaoling
Published: November 2019

Background: The BAHD acyltransferase superfamily exhibits various biological roles in plants, including regulating fruit quality, catalytic synthesizing of terpene, phenolics and esters, and improving stress resistance. However, the copy numbers, expression characteristics and associations with fruit aroma formation of the BAHD genes remain unclear.
Results: In total, 717 BAHD genes were obtained from the genomes of seven Rosaceae, ( Pyrus bretschneideri , Malus domestica , Prunus avium , Prunus persica , Fragaria vesca , Pyrus communis and Rubus occidentalis ). Based on the classifications in model plants, we divided the BAHD family genes into seven groups, I-a, I-b, II-a, II-b, III-a, IV and V. An intra-species synteny analysis detected 78 syntenic gene pairs among the seven Rosaceae species. Dispersed gene duplication occurred frequently in all the investigated species. Different modes of duplicated gene pairs identified in each investigated species revealed that the Ka/Ks ratios were less than one, indicating that they evolved through purifying selection. Based on the correlation analysis between the ester content and expression levels of BAHD genes at different developmental stages, we selected five genes for verification as assessed by qRT-PCR. Pbr020016.1 , Pbr019034.1 , Pbr014028.1 and Pbr029551.1 are important candidate genes involved in aroma formation during pear fruit development.
Conclusion: We have thoroughly annotated the BAHD superfamily genes and performed a comprehensive comparative analysis of their colinearity, phylogenetic relationships and gene duplication patterns in seven Rosaceae species, and we also obtained four candidate genes involved in aroma synthesis in pear fruit. These results provide a theoretical basis for future studies of the specific biological functions of BAHD superfamily members and the improvement of pear fruit quality.
Keywords : BAHD, pear, evolution, Rosaceae, transcriptome, volatile esters
Pregnancy outcomes of Q fever : Prospective follow-up study on Reunion Island
Authors: Mboussou Yoan , Jaubert Julien , Larrieu Sophie , Atiana Laura , Naze Florence , Folio Christine , Randrianaivo Hanitra , Bertolotti Antoine , Picot Sandrine , Robillard Pierre-Yves , Boukerrou Malik , Gérardin Patrick
Published: November 2019

Background Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs.
Methods Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders.
Results Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women with an acute Q fever, the chronology between the onset of infection, the APO (2 miscarriages, 1 preterm birth) and the seroconversion suggested causality in the pathogenesis. The cumulative incidence of Q fever related APOs was estimated between 2.2‰ and 5.2‰, whether causality was required or not. Both C. burnetii exposure and acute Q fever were independently associated with APOs (IRR 1.55, 95% CI 1.31-1.84; IRR 1.47, 95% CI 1.15-1.89, respectively).
Conclusions In the endemic context of Reunion island, acute Q fever may lead to APOs. To limit the burden of Q fever on reproduction, pregnant women should be kept away from farms and avoid direct contact with ruminants.
Association between Severe Unaddressed Dental Needs and Developmental Health at School Entry in Canada: A Cross-sectional Study
Authors: Janus Magdalena , Reid-Westoby Caroline , Lee Catherine , Brownell Marni , Maguire Jonathon L.
Published: November 2019

Background and Objective Dental problems are the most prevalent chronic disease worldwide, with up to half of all kindergarten children having tooth decay. However, there is a lack of evidence of whether unaddressed dental needs (UDNs) are associated with children’s developmental health, a concept reflecting holistic child development - encompassing physical, emotional, and cognitive development. The objective of the current study was to evaluate the relationship between UDNs and developmental health among kindergarten children using the Early Development Instrument (EDI). Methods We examined associations between teacher reported UDNs and developmental vulnerability on the EDI. Children were included in the study if they were enrolled in kindergarten in publicly-funded schools in Canada between 2010 and 2015, had been in the classroom for at least one month, and had no more than 25% of missing items on the questionnaire. Results Among 576,264 children who met inclusion criteria (95.4% of eligible children), 2,465 (0.4%) were identified as having UDNs by their teachers. Children with UDNs had 4.58 to 8.27 times higher odds of being vulnerable on any of the five developmental domains (physical health and well-being, social competence, emotional maturity, language and cognitive development, communication skills and general knowledge), compared to children without UDNs. Conclusion In this study, teacher-reported UDNs were associated with developmental vulnerability in kindergarten children. Teacher reported unmet dental needs in kindergarten children may be a proxy for poor developmental health at school entry, and thus a marker for supporting both children’s oral health and early developmental needs.
Comparison of dental plaque reduction after use of electric toothbrushes with and without QLF-D-applied plaque visualization: A 1-week randomized controlled trial
Authors: Akifusa Sumio , Isobe Ayaka , Kibata Kanako , Oyama Akinori , Oyama Hiroko , Ariyoshi Wataru , Nishihara Tatsuji
Published: November 2019

Background: To evaluate the efficacy of a newly developed electric toothbrush in reducing dental plaque via a quantitative light-induced fluorescence-digital (QLF-D)-applied visualisation system in the brush head.Methods: Participants included 20 adults aged 19 to 28 years. Participants were randomly assigned either (i) an electric toothbrush with a monitor to visualise red-fluorescent dental plaque via a camera built into the brush head (monitor usage group, n = 10) or (ii) an electric toothbrush without a monitor (monitor-non-use group, n = 10). The amount of dental plaque was assessed by personal hygiene performance (PHP) at baseline and 1 week later.Results: In the monitor-usage group, PHP score was significantly lower at the 1-week follow-up than at baseline (6 vs 16; range, 0–12 vs 13–21; P = 0.029). This change was not observed in the monitor-non-use group (14 vs 13; range, 6-21 vs 2-26; P = 0.778). After 1 week, the change in PHP scores in the monitor usage group was significantly greater than that in the monitor non-use group (−10 vs 0; range, -21 to 9 vs -8 to 16; P = 0.021).Conclusions: Our results clearly demonstrate that brushing teeth while looking at a monitor that depicts red-autofluorescent dental plaque via application of QLF-D improved the efficacy of dental-plaque removal relative to brushing teeth without a monitor.
Bismuth Containing Quadruple Therapy versus Tailored Therapy as first-line treatments for Helicobacter pylori infection in a high clarithromycin resistance area
Authors: Bang Byoung Wook , Shin Jong Beom , Ko Eun Jung , Kwon Kye Sook , Shin Yong Woon , Suh Young Ju , Kim Hyungkil , Ko Weonjin
Published: November 2019

Background Increasing clarithromycin resistance has led to the need for an alternative first-line therapy for the eradication of Helicobacter pylori (H. pylori) in Korea, and bismuth containing quadruple therapy (BQT) and tailored therapy (TT) have been proposed as alternative regimens. The aim of this study was to compare the eradication rates of BQT and TT as first-line H. pylori eradication therapies. Methods H. pylori infection was diagnosed using the rapid urease test or dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) during endoscopy. Patients positive for H. pylori were divided into two groups; those tested using the rapid urease test received empirical BQT (the BQT group) whereas those tested by DPO-PCR received TT (the TT group). Eradication rates, adverse events, and overall medical costs, which included diagnostic test and eradication regimen costs, were compared. Results Three hundred and sixty patients were included in the study (TT group 178, BQT group 182). The modified intention-to-treat eradication rates of BQT and TT were 88.2% (142/161) and 80.3% (118/147), respectively (p=0.055), and corresponding eradication rates in the per-protocol population were 88.8% (142/160) and 81.4% (118/145) (p=0.07). Compliance and adverse event rates were similar in the two groups. Average medical costs were $ 90.3 per patient in the TT group and $ 75.5 in the BQT group (p=0.000). Conclusions Empirical BQT and tailored therapy were similar in terms of H. pylori eradication rate, safety, and tolerability, but BQT was more cost-effective.
Morphological, molecular and pathological appraisal of Hymenolepis nana (Hymenolepididae) infecting laboratory mice Mus musculus
Authors: Al-Olayan Ebtsam , Abdel-gaber Rewaida , Aloufi Abeer , Alanazi Zainab
Published: November 2019

The authors have withdrawn this preprint from Research Square
Validation and evaluation of a common biomarker in human cancers sera protein detected by a monoclonal antibody UNIVMab
Authors: Dandi Manjunath , Kumaraswamy Sunil B , V Shashidhara A , Appaiah Hitesh N , Thomas Anil , BANERJEE SHIBDAS
Published: November 2019

Abstract
Objective:
Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hyaluronan binding protein not detected earlier. We applied this test both with ELISA, Western blot, fractionated in anion exchange, cibacron gel exclusion, b-Hyaluronan interaction and HA-Oligo competition from various grades of Human cancers sera and processed for the detection of hyaluronan binding protein H11, reacted with Monoclonal antibody UNIVMab and with b-HA.
Results:
Studies from ELISA, Western blot and b-Hyaluronan interactions showed a definitive positive over-expression of UNIVMab reacted H11 antigen in all fortyfive cancer sera compared to normal sera and can be used as a common biomarker. We believe, UNIVMab detected H11 antigen, a unique hyaluronan binding protein, is a common biomarker for all cancer sera.
Keywords:
ELISA, Western blot, Hyaluronic acid binding protein, H11 (sera antigen), UNIVMab. Common Biomarker, Cancers Sera
Finite Elements Analysis of the Temporomandibular Joint Disc in Patient with Intra-articular Disorders
Authors: Lai Linfeng , Xiong Guofeng , Huang Chenyao , Zhou Fan , Xia Fujian
Published: November 2019

Abstract
Background：Anterior and/or medial displacement of the articular disc or intra-articular disorders( ID) is the most common form of TMJ dysfunction.In the present study,3D finite elements analysis (FEA) models including the maxilla, disc and mandible were established using 3D data registration technology.Methods：Six healthy volunteers and 20 TMD patients were selected.CT and MRI data were collected to build 3D FEA model of mandibular and TMJ disc.Stress distribution with different friction coefficient was measured.Result:Results showed that maximum stress of the lateral articular disc in the normal and pathological models. In the normal model, stress distribution was 2.21,1.56,1.49 MPa with 0.001 0.3 and 0.4 friction coefficient.In ID model,stress distribution is 3.87,7.23,7.77MPa respectively. Conclusion:When the friction coefficient of the side with anterior displacement increased, stress on the disc, condyle and mandible of the opposite side increased. Simultaneously, stress values of the disc, condyle and mandible were higher than those of the normal lateral joint.
Potent antibacterial activity of Dihydydropyrimidine-1,3,5-triazines via inhibition of DNA gyrase and antifungal activity with favourable metabolic profile
Authors: Masih Anup , Shrivastava Jitendra Kumar , Bhat Hans Raj , Singh Udaya Pratap
Published: November 2019

The compounds were tested against panel of three Gram-positive, viz. Staphylococcus aureus, Bacillus subtilis, Bacillus cereus and three Gram-negative bacterial strains viz. Pseudomonas aeruginosa, Escherichia coli, and Proteus vulgaris for determination of their antibacterial efficacy using cefixime as a standard drug. The antibiofilm activities of the compounds were determined against Staphylococcus aureus, and Bacillus subtilis. The most potent compounds 7l amd 7m found bacteriostatic in time kill assay via inhibition of DNA Gyrase enzyme. The metabolic liability of compound 7m was determined using RS-Predictor and MetaPrint 2D React. The antifungal activity against human fungal pathogens was also estimated, where these compounds showed considerable activity in comparison to standard. The in vivo antibacterial activity of compound 7m was also determined using S. aureus induced murine infection model.
Early same-admission laparoscopic cholecystectomy for acute mild biliary pancreatitis: a retrospective study
Authors: lyu yunxiao , Cheng Yunxiao , Wang Bin
Published: November 2019

Background As the standard procedure for the surgical treatment for gallbladder stones, we investigated the controversy surrounding the optimal time for laparoscopic cholecystectomy (LC) for acute mild biliary pancreatitis.Methods This retrospective study included medical records of all patients who were admitted with a diagnosis of acute mild biliary pancreatitis at Dongyang People’s Hospital from July 2011 to June 2018. Main outcomes included perioperative characteristics, length of hospital stay, complications, morbidity, and mortality.Results A total of 119 patients were divided into an early LC group (Group I; 52 patients) and a control group (Group II; 67 patients). The mean age was 60.5 years (range, 30–79 years). Conversion to open cholecystectomy (COC) was performed in 17 patients (6 patients in Group I and 11 patients in Group II, P=0.62). There were no significant differences in terms of estimated blood loss and duration of surgery (P=0.08 and P=0.64, respectively). Bile duct injury (BDI) occurred in one patient from each group. The overall hospital stays in Group I were significantly less than in Group II (10.86±3.21 vs 13.29±4.51, P=0.001). Compared with postoperative bile leakage (P=0.72) and postoperative morbidity (P=0.97) and mortality, there were no significant differences between the groups.Conclusions Early LC during the same admission is safe for acute mild biliary pancreatitis and has the advantage of shortening overall hospital stay. There was no significant increase in COC, BDI, and complications.
Presbyopia Management with Diffractive Phakic Posterior Chamber IOL.
Authors: Bianchi Germán Roberto
Published: November 2019

Background : To evaluate safety and refractive efficiency after posterior chamber diffractive implantable phakic contact lens (IPCL) surgery was performed.Methods: A prospective n on-randomized observational case-series study was performed in 54 myopic eyes from 27 patients who underwent diffractive IPCL surgery. The corneal endothelial cell density (ECD), central corneal thickness (CCT), intra-ocular pressure (IOP), vault, uncorrected distance (UDVA), spherical equivalent (SE) and defocus curve, were evaluated 12 months after implantation of the diffractive IPCL. By slit-lap, the presence of cataract was evaluated during post-operative follow-up. Results: Mean age was 47 ±2.62 years-old. The mean SE decreased from -5.95 ±2.56 D pre-operatively to -0.25 ± 0.25 D at 12 months after surgery . The UDVA achieved was 20/20 in 24.1%, 20/25 in 74.1%, remaining eyes obtained 20/32, and no eye lost lines of vision. The binocular defocus curve was 0.06 ±0.05 logMAR for -3.0 D of defocus, 0.11 ±0.04 logMAR for -1.5 D of defocus and 0.08 ±0.03 logMAR for 0 D of defocus. The mean ECD decrease 1.43% and the mean CCT increase 0.06% at 12 months post-operative, without a statistically significant difference ( p : 0.28 and p : 0.93 respectively). No difference ( p : 0.86) in vault was observed at 6 months vs. 12 months, as well as between IOP measurements ( p : 0.22). Non intra or post-operative complications occurred, and specifically cataract did not develop.Conclusions: Diffractive IPCL was implanted safely. Corneal endothelial CD, CCT, vault and IOP remained stable 12 months after surgery. Visual acuity for distance, intermediate and near sight could be improved without spectacles in myopic population with presbyopia.
Epidemiology characteristics for non-myopic Chinese children aged 6 to 12 years in Jiangsu Province
Authors: Zhang Xiyan , Zhou Yonglin , Yang Jie , Wang Yan , Yang Wenyi , Gao Liuwei , Xiang Yao , Zhang Fengyun
Published: November 2019

Background: We aimed to present epidemiology characteristics including SE value, age, BMI, sex for non-myopic Chinese children after indicating the prevalence of myopia among children aged six to twelve . Based on these we were trying to develop alert values for predicting the future onset of myopia. Methods: All students took part in the ophthalmic examination filled in a questionnaire to provide basic demographic information. We used an autorefractor applying with cycloplegia to obtain spherical equivalent value, and part of their parents filled in a questionnaire of factors related to myopic among children. Results: We finally had 3900 non-myopic observations from 6362 students, and the prevalence of myopia is 38.0% for boys and 39.5% for girls respectively. The average values for SE were 0.5±0.7 for boys and 0.6±0.8 for girls respectively. The mean SE decreased with age in children, and the value of height and BMI took on a stable trend. Alert values for myopia could be set as follows, for children aged six years of age, 0.4-0.6 D for boys and 0.8-1.0 D for girls respectively. For children aged seven years of age, 0.4-0.6 D for boys and 0.3-0.5 D for girls respectively, for children aged eight years, 0.2-0.4 D for boys and 0.3-0.5D for girls, for children aged nine years, 0.2-0.4 D for boys and 0.3-0.4D for girls, 0.1-0.3 D for boys aged ten and 0.3D for girls aged ten years, 0.10-0.3 D for boys aged eleven and -0.3-0.3 D for girls aged eleven years, and for children aged twelve ,-0.1-0.1 D for boys and -0.3-0.1 D for girls aged twelve years. Father’s myopia ( OR:1.22,95%CI:1.01-1.48 ), near work on weekends (OR:2.56,95%CI:1.17-5.61) and outdoor activities (OR:0.68,95%CI:0.54-0.86) had an impact to non-myopic students with myopic alerting. Conclusion: Our study presented an epidemiology description for non-myopic students in Jiangsu Province, and we proposed a series of alert values to provide early warning reference for Chinese children aged six to twelve years. We draw a nomograph to predict the probability of myopia onset and found that family, near work and outdoor activities, had an impact on non-myopic students with myopic alerting.
A novel approach to sample size determination of clinical trials for rare diseases assuming symmetry
Authors: Wang Emma , North Bernard , Sasieni Peter
Published: November 2019

Abstract Background Rare and uncommon diseases are difficult to study in clinical trials due to limited recruitment. If the incidence of the disease is very low, international collaboration can only solve the problem to a certain extent. A consequence is a disproportionately high number of deaths from rare diseases, due to unclear knowledge of the best way to treat patients suffering from these diseases. Hypothesis testing using the conventional Type I error in conjunction with the number of patients who can realistically be enrolled for a rare disease, would cause the trial to be severely underpowered. Methods Our proposed method recognises these pragmatic limitations and suggests a new testing procedure, wherein conclusion of efficacy of one arm is grounded in robust evidence of non-inferiority in the endpoint of interest, and reasonable evidence of superiority, over the other arm. Results Simulations were conducted to illustrate the gains in statistical power compared with conventional hypothesis testing in several statistical settings as well as the example of clinical trials for Merkel cell carcinoma, a rare skin tumour. Conclusions Our proposed analysis method enables conducting clinical trials for rare diseases, potentially leading to better standard of care for patients suffering from rare diseases
Non-steroidal anti-inflammatory drug-induced enteropathy as a major risk factor for small bowel bleeding
Authors: Lim Doo-Ho , Jung Kyoungwon , Lee Seung Bum , Park In Kyu , Cha Hee Jeong , Park Jae Ho , Kim Byung Gyu , Jung Seok Won , Jeong In Du , Kim Jae Hyun , Kim Sung Eun , Moon Won , Park Moo In , Park Seun Ja
Published: November 2019

Background: Small bowel (SB) bleeding has been known to account for 5% of all gastrointestinal (GI) bleeding cases and 80% of obscure GI bleeding cases. Although angioectasia is the common etiology of SB bleeding, non-steroidal anti-inflammatory drug (NSAID)-induced SB lesion is also reported as a major cause in previous studies from the Eastern countries. Herein, we assessed the frequency of NSAID-induced SB lesion in Korean patients with obscure GI bleeding. Methods: We retrospectively analyzed medical records of all consecutive patients aged ≥18 years who underwent capsule endoscopy from March 2018 to February 2019 at Ulsan University Hospital and Kosin University Gospel Hospital. Results: Of the 83 subjects (age, mean ± standard deviation: 59 ± 18 years; age range: 18–84 years; men, n=52; women, n=31), 55 (66.2%) had a clear bloody stool and 28 (33.8%) had a normal stool, but all had iron deficiency anemia. A significantly higher frequency (40 of 51) of ulcerative/erosive lesions was observed in patients with inactive bleeding but visible SB lesions than other causes, and as a result, NSAID-induced enteropathy accounted for 41.7% (25 of 60) of all SB bleeding cases. Conclusions: Contrary to findings of previous studies from the Western countries, ulcerative/erosive lesions were found to have higher occurrence than angioectasia in this study, with an implication of NSAIDs in the etiology of obscure GI bleeding. Aggressive small intestine examination is required for patients with unexplained GI bleeding.
lncRNA_Mdeep: an alignment-free predictor for long non-coding RNAs identification by multimodal deep learning
Authors: Fan Xiao-Nan , Zhang Shao-Wu , Zhang Song-Yao , Ni Jin-Jie
Published: November 2019

Background: Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming. Results: In this study, we present an alignment-free multimodal deep learning framework (namely lncRNA_Mdeep) to distinguish lncRNAs from protein-coding transcripts. LncRNA_Mdeep incorporates three different input modalities (i.e. OFH modality, k-mer modality, and sequence modality), then a multimodal deep learning framework is built for learning the high-level abstract representations and predicting the probability whether a transcript is lncRNA or not.Conclusions: LncRNA_Mdeep achieves 98.73% prediction accuracy in 10-fold cross-validation test on human. Compared with other eight state-of-the-art methods, lncRNA_Mdeep shows 93.12% prediction accuracy independent test on human, which is 0.94%~15.41% higher than that of other eight methods. In addition, the results on 11 cross-species datasets show that lncRNA_Mdeep is a powerful predictor for identifying lncRNAs. The source code can be downloaded from https://github.com/NWPU-903PR/lncRNA_Mdeep.
Evaluation of oral care protocols practice by professionals towards HIV/AIDS individuals
Authors: Silva-Boghossian Carina Maciel , Boscardini Brenda Azzariti Berrondo , Pereira Claudia Maria , Moreira Edson Jorge Lima
Published: November 2019

Background The aim of this study was to evaluate the dentists’ knowledge and practice regarding HIV positive individuals’ oral care.Methods Dentists from Rio de Janeiro State (n = 242) answered an electronic questionnaire on biosafety procedures, oral manifestations of AIDS, and knowledge of HIV infection. Data were analyzed using Chi-square and t tests.Results From the 14 oral manifestations investigated, oral candidiasis, necrotizing ulcerative gingivitis, and hairy leucoplakia were more associated with HIV, with no differences between the responses from men and women. Above 85% of the participants would be concerned about becoming infected with HIV after a needle/ sharp object injury and more than 80% them were willing to be tested for HIV. However, significantly more women (98.8%), compared to men (91.3%), said they knew that HIV/ AIDS patients can contaminate dental care professionals, p = 0.007. There was a significant difference in the answers for the questions: “Are there special dental clinics for treatment of HIV/AIDS patients in Brazil?” (p = 0.044), and “Do the negative HIV tests surely indicate that the persons are free of viruses?” (p = 0.005). Significant differences between men and women were also observed regarding use of disposable mask (p = 0.01), and cap (p < 0.0001).Conclusion Most dentists who participated in the study presented a good knowledge on the care of HIV/ AIDS individuals, including biosafety protocols and in terms of the oral manifestations commonly associated to AIDS.
The propionic acid and butyric acid in serum but not in feces are increased in patients with diarrhea-predominant irritable bowel syndrome
Authors: Tian Zhenyi , Zhuang Xiaojun , Luo Mei , Yin Wei , Xiong Lishou
Published: November 2019

Background & Aims ： Short-chain fatty acids (SCFAs) play a pivotal role in maintaining homeostasis in humans. It might be involved in the pathogenesis of irritable bowel syndrome (IBS). Our study aims to explore the alteration of SCFAs in patients with diarrhea-predominant IBS (IBS-D). Methods： We recruited patients with IBS-D defined by Rome Ⅳ criteria and age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography–mass spectrometric (HS-SPME-GC-MS) method was developed for the analysis of acetic, propionic and butyric acid in feces and serum. Results: Compared with HCs, the levels of the serum propionate (2.957 ± 0.157 vs 2.843 ± 0.098 mmol/L, P = 0.012) and butyrate (2.798 ± 0.126 vs 2.697 ± 0.077 mmol/L, P = 0.012) were significantly higher in IBS-D group. No significant differences were found among two groups with regard to the concentration of fecal acetate (4.953 ± 1.065 vs 4.774 ± 1.465 mg/g, P = 0.679), propionate (6.342 ± 1.005 vs 6.282 ± 1.077 mg/g, P = 0.868) and butyrate (2.984 ± 0.512 vs 3.071 ± 0.447 mg/g, P = 0.607). Conclusions ： Metabolites of gut microbiota, the propionic and butyric acid, are increased in patients with IBS-D in serum but not in feces. It suggests that propionic and butyric acid might be involved in the pathogenesis of IBS.