bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Dust Storms on Non-Accidental, Cardiovascular, and Respiratory Mortality: A Case of Dezful City in Iran
Authors: Aghababaeian Hamidreza , Ostadtaghizadeh Abbas , Ardalan Ali , Asgary Ali , Akbary Mehry , Yekaninejad Mir Saeed , Sharafkhani Rahim , Stephens Carolyn
Published: November 2021

Background:

Despite the fact that Iran has been exposed to severe dust storms during the past 2 decades, few studies have investigated the health effects of these events in Iran. This study was conducted to assess the association between dust storms and daily non-accidental, cardiovascular, and respiratory mortality in Dezful City (Khuzestan Province, Iran) during 2014 to 2019.

Methods:

In this study, mortality, meteorological, and climatological data were obtained from the Dezful University of Medical Sciences, Iranian Meteorological Organization, and Department of Environment in Khuzestan Province, respectively. Days of dust storm were identified based on the daily concentration threshold of particulate matter with an aerodynamic diameter of less than 10 μm (PM10) according to Hoffmanns҆ definition, and then an ecological time-series was used to estimate the short-term effects of dust storms on daily mortality. Statistical analysis was performed using a distributed lag linear model (DLM) and a distributed lag non-linear model (DLNM) packages by R software and the study results were reported as excess mortality.

Results:

During the study period, 15 223 deaths were recorded, and 139 dust storms occurred in Dezful city. In addition, there was statistically significant excess risk of mortality due to dust storms in Dezful City (mortality in the group under 15 years of age, lag4: 34.17% and 15-64 years of age groups, lag5: 32.19%, lag6: 3.28%), also dust storms had statistically significant effects on respiratory mortality (lag6: 5.49%).

Conclusion:

The findings of the current study indicate that dust storms increase the risk of mortality with some lags. An evidence-based early warning system may be able to aware the people of the health effects of dust storms.
A Survey of Topical Cannabis Use in Canada
Authors: Mahmood Farhan , Lim Megan M. , Kirchhof Mark G.
Published: November 2021

Background

Since its legalization in Canada, cannabis use has expanded to include commercially available topical formations. Several scientifically unsupported claims regarding the therapeutic efficacy of topical cannabis are also being made. Developing an understanding of the consumer uses of topical cannabis is important for clinicians to provide appropriate counseling and inform potential areas of therapeutic development. We are examining the prevalence, purpose of use, and sources of information regarding topical cannabis in the Canadian population, with a focus on dermatologic uses.

Method

A cross-sectional, anonymous electronic, voluntary survey was developed to assess the use of topical cannabis amongst adults in Canada.

Results

Cannabis was used topically at least once by 24.3% of respondents who started the survey. The commonest form of topical cannabis were creams (26.2%). The most common dermatologic conditions being treated with topical cannabis included atopic dermatitis (25%), acne (19%), and anti-aging (16%); for non-dermatologic conditions, common uses were for joint stiffness or tendonitis (30%) and headaches and migraines (27%). Topical cannabis was reported to be most effective for joint stiffness and tendonitis, general muscular soreness, headaches, eczema, pruritus, acne, and psoriasis. Most respondents obtained and received information about topical cannabis from dispensaries.

Conclusion

Canadians use topical cannabis for a broad range of systemic and dermatologic purposes, most of which have limited evidence. Future clinical studies are required to elucidate the therapeutic efficacy and safety of topical cannabis. Dermatologists should screen their patients for topical cannabis use and be aware of the limited evidence of therapeutic potential.
Framing the startup accelerator through assemblage theory: A case study of an intensive hub in Indonesia
Authors: Luik Jandy , Hook Jonathan , Ng Jenna
Published: November 2021

This article presents how assemblage theory, as taken from Deleuze and Guattari, can be used to understand the intensive approaches of startup accelerators in supporting startup companies. Through a study of a startup accelerator in Jakarta, Indonesia, we present three snapshots to exemplify manifestations of what we argue as the accelerator’s “ seed accelerator” form of content and “ seed funding” form of expression as well as their reciprocal presupposition to demonstrate the multiplicity of assemblage as the organizational principles of the accelerator. Employing the tenets of formalization and territorialization from assemblage theory to analyze the results, this article shows that the “ seed accelerator” form of content is manifested by way of how the accelerator’s bodies of its human elements, activities, events, and infrastructure relate and interconnect throughout the accelerator’s 12-week program towards its end point, that is, fulfilling the stakes for the Final Demo-Day, while, on the other hand, the “ seed funding” form of expression is manifested by way of the usage of terms related to fund-raising, expressions of worry, and the expectations of the hub management and the VC in preparing the startups for the next level of funding. Moreover, we argue that the formalized function of the accelerator assemblage is to intensively seed scalable startups. This assemblage analysis thus offers an interrelational perspective regarding startup accelerators, and demonstrates the value of formalization and territorialization in assemblage theory to understand the programming arrangements in a startup accelerator.
Investigating preservice classroom teachers’ practices and views about teaching physical education lessons: An exploratory case study
Authors: Tsangaridou Niki , Kyriakides Ermis , Charalambous Charalambos Y.
Published: November 2021

Focusing on preservice classroom teachers (PCTs) with a physical education (PE) specialization, this exploratory case study aimed at investigating the teaching quality in the lessons offered by these teachers during their field placement, as well as examining their views about teaching PE. Toward this end, seven volunteer female PCTs studying at a national university in Cyprus were recruited; all had attended three PE specialization courses before their field placement. Data were gathered through systematic observations, semi-structured interviews, and document analysis. The quantitative data were analysed using SPSS and the qualitative data using case and cross-case analysis. These analyses suggested that the PCTs could effectively employ classroom and time management as well as skill demonstration; they could also provide quality student practice. In contrast, task progression, accountability of student practice, and task explicitness appeared to be more challenging for them to successfully enact. Interestingly, their lesson plans foreshadowed how effectively most of the examined practices would be employed by the PCTs. This study contributes a new understanding of PCTs’ PE teaching during field placement and their views thereof. The implications of the findings for PCTs’ education are discussed.
Too old for technology? Use of wearable healthcare devices by older adults and their willingness to share health data with providers
Authors: Chandrasekaran Ranganathan , Katthula Vipanchi , Moustakas Evangelos
Published: November 2021

Wearable healthcare devices offer tremendous promise to effectively track and improve the well-being of older adults. Yet, little is known about the use of wearable devices by older adults. Drawing upon a national survey in US with 1481 older adults, we examine the use of wearable healthcare devices and the key predictors of use viz. sociodemographic factors, health conditions, and technology self-efficacy. We also examine if the predictors are associated with elders’ willingness to share health data from wearable devices with healthcare providers. We find low level of wearable use (17.49%) among US older adults. We find significant positive associations between technology self-efficacy, health conditions, and demographic factors (gender, race, education, and annual household income) and use of wearable devices. Men were less likely (OR = 0.62, 95% CI 0.36–1.04) and Asians were more likely (OR = 2.60, 95% CI 0.89–7.64) to use wearables, as did healthy adults (OR = 1.98, 95% CI 1.37–2.87). Those who electronically communicated with their doctors (OR = 1.86, 95% CI 1.16–2.97), and those who searched online for health information (OR = 1.79, 95% CI 1.03–3.10) were more likely to use wearables. Though 80.15% of wearable users are willing to share health data with providers, those with greater technology self-efficacy and favorable attitudes toward exercise are more willing.
Application of radial basis function-based meshless method for torsional analysis of elliptical and bone shaped-irregular sections
Authors: Prasad Ram Bilas , Singh Jeeoot , Shukla Karunesh Kumar
Published: November 2021

This article presents a torsional analysis of solid elliptical, hollow circular, and actual bone sections of orthotropic and functionally graded material. The formulation of the governing equation is done using the Saint-Venant torsion theory. A classical power law is considered for the modelling of functionally graded material. Five different radial basis functions-based meshless methods are used for the discretization of the governing differential equations. MATLAB code is developed to solve the discretized partial differential equations. A convergence and validation study has been carried out to demonstrate the effectiveness and accuracy of the present method. Numerical examples for torsional rigidity and shear stresses are presented for circular, elliptical, and bone-shaped irregular sections made up of orthotropic and functionally graded materials. Finally, the proposed radial basis function-based meshless method is applied to the modelling and torsional analysis of an actual bone cross-section.
Multilingualism and the International Baccalaureate Diploma Programme (IBDP): An Analysis of Language Learning in the IBDP in Light of the ‘Multilingual Turn’
Authors: Huckle Jacob
Published: November 2021

This article analyses various International Baccalaureate policy documents to establish whether the International Baccalaureate Diploma Programme has undergone what is described as a multilingual turn. After defining multilingualism and the multilingual turn, it outlines three main implications of what might be considered this paradigm shift for educational policies related to curriculum, pedagogy, and assessment. These implications are used as a framework for the policy analysis to follow, which argues that International Baccalaureate Diploma Programme approaches to language learning are underpinned by a monolingual bias that might delegitimate the knowledge and experience of multilingual learners.
Being and becoming internationally minded: Snapshots of novice Canadian teachers in international schools
Authors: Budrow James
Published: November 2021

This paper examines the experiences of three Canadian teachers beginning their formal careers in international schools. International mindedness is taken up as a sensitivity that international schoolteachers both bring to their international teaching assignments and further develop in the transnational spaces of international schools. As such, the internationally minded teacher is able to respond and learn from the intercultural complexities of teaching and living overseas. Findings suggest some elements of international mindedness are more readily appreciated and practiced by these novice teachers while others require greater awareness and effort to attain. The findings also suggest that ‘cosmopolitan learning’ (Rizvi, 2009), foregrounding the importance of critically reflecting upon one’s ‘locatedness’ in the world, represents a generative orientation for teachers wanting to deepen their international mindedness.
Comparison of the Outcomes of Total Endovascular Aortic Arch Repair Between Branched Endograft and Chimney Endograft Technique in Zone 0 Landing
Authors: Kudo Tomoaki , Kuratani Toru , Shirakawa Yukitoshi , Shimamura Kazuo , Kin Keiwa , Sakamoto Tomohiko , Shijo Takayuki , Watanabe Yoshiki , Masada Kenta , Sakaniwa Ryoto , Sawa Yoshiki
Published: November 2021

Purpose:

Zone 0 landing in thoracic endovascular aortic repair (TEVAR) has recently gained increasing attention for the treatment of high-risk patients. The aim of this study was to compare the outcomes of total endovascular aortic arch repair between branched TEVAR (bTEVAR) and chimney TEVAR (cTEVAR) in the landing zone (LZ) 0.

Materials and Methods:

This was a single-center, retrospective, and observational cohort study. From January 2010 to March 2020, 40 patients (bTEVAR, n=25; cTEVAR, n=15; median age: 79 years) were enrolled in this study, with a median follow-up period of 4.1 years. These patients were considered unsuitable for open surgical treatment.

Results:

All procedures were successful and no cases of conversion to open repair were noted during the 30-day postoperative period. The 30-day mortality was 2.5% (n=1; bTEVAR [0 of 25, 0%] vs cTEVAR [1 of 15, 6.7%]; p=0.375), the perioperative stroke rate was 10.0% (n=4; bTEVAR [4 of 25, 16.0%] vs cTEVAR [0 of 15, 0%], p=0.278), and type 1a endoleak rate was 15.0% (n=6; bTEVAR [0 of 25, 0%] vs cTEVAR [6 of 15, 40.0%], p=0.001). The risk factor for stroke was atheroma grade of ≥2 in the brachiocephalic artery (p<0.001). The risk factor for type 1a endoleak was cTEVAR (p=0.001). The 8-year survival rate was 49.9%. The aorta-related death-free rate and aortic event-free rate at 8 years were 94.4% (bTEVAR: 95.5% vs cTEVAR: 93.3%, p=0.504) and 60.7% (bTEVAR: 70.7% vs cTEVAR: 40.0%, p=0.048), respectively.

Conclusions:

Total endovascular aortic arch repair using bTEVAR and cTEVAR is feasible for the treatment of aortic arch diseases in high-risk patients who are unsuitable for open surgery. However, as the rate of stroke is high, strict preoperative evaluation to prevent stroke is needed. No rupture of the aneurysm was observed in cTEVAR, but patients should be selected carefully because of the high incidence of type 1a endoleak.
The Effects of COVID-19 on External Political Efficacy
Authors: McBrayer Markie Rae , Baumgaertner Bert , Justwan Florian
Published: November 2021

Significant scholarship examines the effects of disasters and disaster management on political behavior and attitudes. Yet, no research has assessed how health crises might shape people’s levels of external efficacy, nor how disaster response affects external efficacy beyond localized extreme-weather events. Using the United States as a case study, we seek to fill these gaps in the literature by exploring how individuals’ external political efficacy is affected by assessments of the federal COVID response. With an original collection of survey data from April 2020, we find that respondents who view the government’s handling of COVID more positively report higher levels of external efficacy. In a secondary analysis, we performed an experiment in February 2021 where people were given different narratives about government management of the pandemic response. The experimental results strongly suggest that disaster management—in this case the handling of the pandemic—shapes individuals’ efficacy.
Exploration of the Tumor Mutational Burden as a Prognostic Biomarker and Related Hub Gene Identification in Prostate Cancer
Authors: Wang Licheng , Yao Yicong , Xu Chengdang , Wang Xinan , Wu Denglong , Hong Zhe
Published: November 2021

To explore the signature function of the tumor mutational burden (TMB) and potential biomarkers in prostate cancer (PCa), transcriptome profiles, somatic mutation data, and clinicopathologic feature information were downloaded from The Cancer Genome Atlas (TCGA) database. R software package was used to generate a waterfall plot to summarize the specific mutation information and calculate the TMB value of PCa. Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was used to select the hub genes related to the TMB from the ImmPort network to build a risk score (RS) model to evaluate prognostic values and plot Kaplan–Meier (K-M) curves to predict PCa patients survival. The results showed that PCa patients with a high TMB exhibited higher infiltration of CD8+ T cells and CD4+ T cells and better overall survival (OS) than those with a low TMB. The anti-Mullerian hormone (AMH), baculoviral IAP repeat-containing 5 (BIRC5), and opoid receptor kappa 1 (OPRK1) genes were three hub genes and their copy number variation (CNV) was relatively likely to affect the infiltration of immune cells. Moreover, PCa patients with low AMH or BIRC5 expression had a longer survival time and lower cancer recurrence, while elevated AMH or BIRC5 expression favored PCa progression. In contrast, PCa patients with low OPRK1 expression had poorer OS in the early stage of PCa and a higher recurrent rate than those with high expression. Taken together, these results suggest that the TMB may be a promising prognostic biomarker for PCa and that AMH, OPRK1, and BIRC5 are hub genes affecting the TMB; AMH, OPRK1, and BIRC5 could serve as potential immunotherapeutic targets for PCa treatment.
Cardiac Dose Control and Optimization Strategy for Left Breast Cancer Radiotherapy With Non-Uniform VMAT Technology
Authors: Qiu Jianjian , Zhang Shujun , Lv Bo , Zheng Xiangpeng
Published: November 2021

Purpose: A novel in-house technology “Non-Uniform VMAT (NU-VMAT)” was developed for automated cardiac dose reduction and treatment planning optimization in the left breast radiotherapy. Methods: The NU-VMAT model based on IGM (gantry MLC Movement coefficient index) was established to optimize the volumetric modulated arc therapy (VMAT) MLC movement and modulation intensity in certain gantry angles. The ESAPI embedded in Eclipse® was employed to connect TPS and the optimization program via I/O relevant DICOM RT files. The adjuvant whole-breast radiotherapy of 14 patients with left breast cancer was replanned using our NU-VMAT technology in comparison with VMAT and IMRT technology. Dosimetric parameters including D1%, D99%, and Dmean of PTV, V5, V10, and V20 of ipisilateral lung, V5, D20, D30, and Dmean of heart, monitor units (MUs), and delivery time derived from IMRT, VMAT, and NU-VMAT plans were evaluated for plan quality and delivery efficiency. The quality assurance (QA) was conducted using both point-dose and planar-dose measurements for all treatment plans. Results: The IGM−NU−VMAT curves with plan optimization (range from 50% to 147%) were converged more significantly than IGM-VMAT curves (range from 0% to 297%). The dose distribution requirements of the target and normal tissues could be met using IMRT, VMAT, or NU-VMAT; the lowest Dmean was achieved in NU-VMAT plans (5.38 ± 0.46 Gy vs 5.63 ± 0.61 Gy in IMRT and 7.95 ± 0.52 Gy in VMAT plans). Statistically significant differences were found in terms of delivery time and MU when comparing IMRT with VMAT and NU-VMAT plans ( P < .05). In comparison with IMRT plans, the MU and delivery time in NU-VMAT plans dramatically decreased by 69.8% and 28.4%, respectively. Moreover, NU-VMAT plans showed a high gamma passing rate (96.5% ± 1.11) in plane dose verification and minimal dose difference (2.4% ± 0.19) in point absolute dose verification. Conclusion: Our non-uniform VMAT facilitated the treatment strategy optimization for left breast cancer radiotherapy with dosimetric advantage in cardiac dose reduction and delivery efficiency in comparison with the conventional VMAT and IMRT.
Post-transplantation Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Patients with Lymphoblastic Lymphoma is an Independent Prognostic Factor with an Impact on Progression-Free Survival but not Overall Survival
Authors: Dai Na , Liu Hang , Deng Shengming , Sang Shibiao , Wu Yiwei
Published: November 2021

Purpose: In the present study, we mainly aimed to evaluate the prognostic value of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]F-FDG) positron emission tomography (PET)/computed tomography (CT) after allogeneic stem cell transplantation (allo-SCT) in lymphoblastic lymphoma (LBL) patients using Deauville Scores (DS). Materials and Methods: A total of 63 LBL patients who benefited from 18F-FDG PET-CT after allo-SCT in our institution between April 2010 and August 2020 were enrolled in this retrospective study. These above-mentioned patients were divided into two groups based on the Deauville criteria. Diagnostic efficiency of 18F-FDG PET/CT and integrated CT in detecting lymphoma were calculated. Consistencies were evaluated by comparing 18F-FDG PET/CT and integrated CT results through kappa coefficient. Kaplan-Meier method was used in survival analysis, and the log-rank method was adopted in comparisons. Prognostic factor analysis was performed by the Cox regression model. Results: The sensitivity, specificity, positive predictive value, negative predictive value, accuracy of post-SCT 18F-FDG PET-CT were 100%(12/12), 92.2%(47/51), 75.0%(12/16), 100%(47/47) and 93.7%(59/63). The consistency of 18F-FDG PET-CT and integrated CT was moderate(Kappa = .702，P < .001). Positive post-SCT 18F-FDG PET-CT was associated with lower progression-free survival (PFS) but not overall survival (OS) (p = .000 and p = .056, respectively). The 3-year PFS of the PET-positive group and PET-negative group was 18.8% and 70.2%, respectively. Multivariate analysis showed that post-SCT PET-CT findings was an independent prognostic factor for PFS (p = .000; HR, 3.957; 95%CI, 1.839-8.514). Other factors independently affecting PFS were sex (p = .018; HR, 2.588; 95% CI, 1.181 − 5.670) and lactate dehydrogenase (LDH) (p = .005; HR, 3.246; 95% CI, 1.419 − 7.426). However, none of the above-mentioned factors were associated with OS. Conclusions: Collectively, we found that 18F-FDG PET-CT after allo-SCT was a strong indicator for PFS, but not OS, which might provide important evidence for the selection of subsequent treatment regimen for LBL patients. Trial registration number: ChiCTR2100046709.
Dosimetric Comparison of Helical Tomotherapy and Intensity-Modulated Proton Therapy in Hippocampus- and Scalp-Sparing Whole Brain Radiotherapy
Authors: Takaoka Taiki , Tomita Natsuo , Mizuno Tomoki , Hashimoto Shingo , Tsuchiya Takahiro , Tomida Masashi , Yanagi Takeshi
Published: November 2021

Objective: Cognitive decline and alopecia after radiotherapy are challenging problems. We aimed to compare whole brain radiotherapy (WBRT) plans reducing radiation dose to the hippocampus and scalp between helical tomotherapy (HT) and intensity-modulated proton therapy (IMPT). Methods: We conducted a planning study of WBRT for 10 patients. The clinical target volume was defined as the whole brain excluding the hippocampus avoidance (HA) region. The prescribed dose was 30 Gy in 10 fractions to cover 95% of the target. Constraint goals were defined for the target and organs at risk (OAR). Results: Both techniques met the dose constraints for the target and OAR. However, the coverage of the target (dose covering 95% [D95%] and 98% [D98%] of the volume) were better in IMPT than HT (HT vs IMPT: D95%, 29.9 Gy vs 30.0 Gy, P < .001; D98%, 26.7 Gy vs 28.1 Gy, P = .002). The homogeneity and conformity of the target were also better in IMPT than HT (HT vs IMPT: homogeneity index, 1.50 vs 1.28, P < .001; conformity index, 1.30 vs 1.14, P < .001). IMPT reduced the D100% of the hippocampus by 59% (HT vs IMPT: 9.3 Gy vs 3.8 Gy, P < .001) and reduced the Dmean of the hippocampus by 37% (HT vs IMPT: 11.1 Gy vs 7.0 Gy, P < .001) compared with HT. The scalp IMPT reduced the percentage of the volume receiving at least 20 Gy (V20Gy) and V10Gy compared with HT (HT vs IMPT: V20Gy, 56.7% vs 6.6%, P < .001; V10Gy, 90.5% vs 37.1%, P < .001). Conclusion: Both techniques provided acceptable target dose coverage. Especially, IMPT achieved excellent hippocampus- and scalp-sparing. HA-WBRT using IMPT is a promising treatment to prevent cognitive decline and alopecia.
Celastrus orbiculatus Extract Reduces Stemness of Gastric Cancer Stem Cells by Targeting PDCD4 and EIF3H
Authors: Zhu Yao-dong , Ba He , Chen Jie , Zhang Mei , Li Ping
Published: November 2021

Background

Celastrus orbiculatus ethyl acetate extract (COE) has shown a strong anti-gastric cancer effect, but the understanding of its mechanism is still lacking. The results of previous studies indicated that COE may be able to inhibit the stemness of gastric cancer stem cells (GCSCs) by regulating PDCD4 and EIF3H expression.

Aims

To explore if COE could inhibit the stemness of GCSCs by regulating PDCD4 and EIF3H expression in vitro and in vivo.

Procedure

The GCSCs model was established by stem cell-conditioned culture. Spheroid formation and flow cytometry assays were used to detect the effect of COE on the spheroid formation ability of GCSCs and the percentage of CD44+/CD24+ and ALDH+ cell subpopulations. Western blot analysis was applied to measure the expression of GCSCs biomarkers (Nanog, Oct-4, and SOX-2), PDCD4, and EIF3H in GCSCs treated with COE; and RT-PCR was performed to investigate the effect of COE on PDCD4 mRNA expression in GCSCs. An in vivo tumorigenicity experiment was also conducted to evaluate the effect of COE on tumor-initiating ability of GCSCs in vivo; and the expression of PDCD4 and EIF3H in xenograft tissues was examined by immunohistochemistry (IHC) staining.

Results

After culture in stem cell-conditioned medium, SGC7901 cells manifested significantly enhanced spheroid formation ability, upregulated Nanog, Oct-4, and SOX-2 expression and increased percentages of CD44+/CD24+ and ALDH+ cell subpopulations, indicating successful establishment of the GCSCs model. COE treatment significantly inhibited the spheroid formation ability of GCSCs and reduced the percentage of CD44+/CD24+ and ALDH+ cell subpopulations. The western blot analysis showed a significant decrease of Nanog, Oct-4, SOX-2, and EIF3H expression and an increase of PDCD4 expression in GCSCs after COE treatment in a concentration-dependent manner. COE treatment also significantly upregulated the mRNA expression of PDCD4 in GCSCs. In addition, COE displayed a strong inhibitory effect on the tumor-initiating ability of GCSCs in vivo and upregulated PDCD4 and downregulated EIF3H expression in xenograft tissues.

Conclusion

COE may be able to inhibit GC growth by suppressing the stemness of GCSCs via regulating PDCD4 and EIF3H expression.
“For the Contrary View”: Reconsidering the Early Anti-Zoning Decisions
Authors: Romero Francine S.
Published: November 2021

When the 1926 Euclid v. Ambler decision found municipal zoning valid under the U.S. Constitution, previous state cases opposing the practice were overruled and subsequently almost forgotten. This investigation analyzes those early State Supreme Court cases to determine systematically the basis of these rejections. After constructing a contextual background of the legal arguments that could have been used by the judges, I assess cases to determine which were used, and find a dominance of concern regarding land use segregation justified by municipalities through an “aesthetics” defense. I conclude by considering links between these cases and current controversies.
Microvascular Flow Imaging in a Case of Portal Vein Thrombosis
Authors: Santarsiere Marika , Rumolo Mariateresa , Vergara Emilia , Brunetti Arturo , Gisonni Pietro
Published: November 2021

Portal vein thrombosis (PVT) is a common complication of liver cirrhosis and is often the first sign of undetected hepatocellular carcinoma. It is crucial to differentiate malignant from benign thrombosis in determining prognosis and treatment. We describe a case of malignant PVT, detected for the first time by a new ultrasound technology, microvascular flow imaging, which can depict low flow in small vessels.
Quantitative Proteomics Analysis of Differentially Expressed Proteins in Serum of Former Uranium Miners by Isobaric Tags for the Relative and Absolute Quantitation
Authors: Dang Xuhong , Lin Haipeng , Yuan Yayi , Yang Biao , Dong Juancong , Zhang Zhongxin , Yang Kai , Li Youchen , Li Xiaozhen , Chai Dongliang , Zuo Yahui
Published: November 2021

The carcinogenicity of radon has been convincingly documented through epidemiological studies of underground miners. However, there is a lack of early warning indicators for radon radiation damage. In this study, mixed serum samples of 3 groups were collected from 27 underground uranium miners and seven aboveground miners according to the radiation exposure dose. The differentially expressed proteins in the serum were identified using the isobaric tags for the relative and absolute quantitation (iTRAQ)-based method. Some differentially expressed proteins were validated by enzyme-linked immunosorbent assay (ELISA) in 84 underground and 32 aboveground miners. A total of 25 co-differentially expressed proteins in 2 underground miner groups were screened, of which 9 were downregulated and 13 were upregulated. Biological process analysis of these proteins using Metascape showed that 5 GO terms were enriched, such as negative regulation of very-low-density lipoprotein particle clearance, endocytosis, and regulated exocytosis. The results of the ELISA for the expression levels of GCN1, CIP2A, and IGHV1-24 in the serum of 116 miners’ serum showed that the levels of GCN1 and CIP2A were consistent with the iTRAQ results. In conclusion, APOC1, APOC2, APOC3, ORM1, ORM2, ANTXR1, GCN1, and CIP2A may be potential early markers of radon radiation damage.
State of the art methods to post-process mechanical test data to characterize the hot deformation behavior of metals
Authors: Khoddam Shahin , Solhjoo Soheil , Hodgson Peter D
Published: November 2021

Materials engineering and science rely heavily on the indirect measurement of plastic stress and strain by post-processing of mechanical test data, including tension, torsion, and compression test. There is no consensus among researchers regarding the best test or the post-processing theory nor do adequate standards exist on the characterization methods. The tests are typically performed as customized tests, discrepancies exist in the flow curves obtained by different methods and the chosen mechanical test. More critically, the curves are dominantly treated (perceived) as a set of measured data rather than calculated values. The plasticity-based calculated flow curves and their gradients are, in turn, the basis for several second-tier indirect measurements, such as stacking fault energy and recrystallization. Such measurements are quite prone to errors due to oversimplified post-processing of the tests’ data and can only be experimentally verified in a qualitative or in an average fashion. Therefore, their findings are highly restricted by the limitations of each test, data type and post-processing method, and should be used carefully. This review examines some of the most commonly used data conversion methods and some recent developments in the field followed by recommendations. It will highlight the need to develop test rigs that can provide new data types and to provide advanced post-processing techniques for the indirect measurement.
Comparison between menstrual cups: first step to categorization and improved safety
Authors: Manley Hannah , Hunt John A , Santos Lívia , Breedon Philip
Published: November 2021

Objectives:

Menstrual cups come in a range of shapes, sizes, and firmnesses, but unlike tampons are not categorized in any way. With these factors having an impact on product leaks and comfort, as well as being linked to illness and injury, women need the same level of transparency when purchasing a menstrual cup. The comparison of physical and mechanical properties of menstrual cups will be the first step to achieve this.

Methods:

In October 2020, 14 popular and highly rated menstrual cups underwent quantitative comparison in laboratory settings (the United Kingdom), and they were compared in terms of their dimensions, volume, and compressive strength (firmness) using the Instron Universal Testing System. The overall designs were compared including shape, material, and features.

Results:

Although all the products in this comparison were marketed to women below 30 years of age having never given birth, total volume varied from 18.88 mL to 38.14 mL, and compressive load to compress the menstrual cup 50% (±0.5%) maximum diameter varied from 3.39 N to 13.92 N.

Conclusions:

Women are not sufficiently informed when choosing a menstrual cup. With no correlation between menstrual cup size, shape, and its volume, or material, shape, and its firmness, consumers cannot estimate which menstrual cup might be most suitable, and incorrect choice could cause injury. Transparency is needed across menstrual cup brands. With this and further regulation, women will make an informed decision to choose the correct menstrual cup and minimize injury. This work recommends firmness categories, ranging from ‘very soft’ to ‘very firm’ as a first step.
Pregnancy‐associated haemolytic anaemia: A cause not to be forgotten
Authors: Creeper Katherine , Graham Dorothy
Published: November 2021

Anaemia in pregnancy is common, however, only a few cases of pregnancy-associated autoimmune haemolytic anaemia have been documented. Typically, such cases involve a positive direct antiglobulin test and have the potential to cause haemolytic disease of the fetus and newborn. Rarely, no autoantibodies are detected. We report two cases of direct antiglobulin test negative haemolytic anaemia occurring in multiparous women with no cause found. Both women had a haematological response to corticosteroid therapy and delivery.
Liposomal irinotecan pre-emptive dose reduction in patients with pancreatic ductal adenocarcinoma: 667 patients’ experience within a population-based study
Authors: Chiu Tai-Jan , Su Yung-Yeh , Yang Shih-Hung , Li Chung-Pin , Bai Li-Yuan , Chiang Nai-Jung , Chuang Shih-Chang , Shan Yan-Shen , Chan De-Chuan , Chen Li-Tzong , Yen Chia-Jui , Peng Cheng-Ming , Chen Yen-Yang , Chen Jen-Shi , Chou Wen-Chi
Published: November 2021

Background:

Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) is currently the standard second-line treatment for patients with pancreatic ductal adenocarcinoma (PDAC) after previous failed gemcitabine-based therapy. This population-based study aimed to evaluate the efficacy and safety of nal-IRI + 5-FU/LV and the association of pre-emptive nal-IRI dosing with treatment outcomes in patients with PDAC.

Methods:

We retrospectively enrolled a total of 667 consecutive patients with PDAC who received nal-IRI plus 5-FU/LV treatment between August 2018 and November 2020 at 9 medical centers in Taiwan. Patients were allocated into groups according to pre-emptive nal-IRI dosing (⩾75%, 50–74%, <50%) for comparison of treatment efficacy and safety.

Results:

The median overall survival (OS) and time to treatment failure (TTF) were 5.9 months [95% confidence interval (CI), 5.3–6.5] and 2.8 months (95% CI, 2.6–3.0), respectively. The median OS was 6.5 months (95% CI, 5.7–6.7), 5.0 months (95% CI, 3.4–6.5), and 4.1 months (95% CI, 2.7–5.6), respectively, among the ⩾75%, 50–74%, and <50% pre-emptive nal-IRI dosing groups, whereas the median TTF of the three groups was 3.0 months (95% CI, 2.6–3.4), 2.6 months (95% CI, 2.3–2.9), and 1.9 months (95% CI, 1.6–2.2), respectively. Pre-emptive nal-IRI dosing <50% was an independent negative prognostic factor for OS and TTF in multivariate analyses. The most common severe adverse events were neutropenia (22.9%), anemia (21.1%), and hypokalemia (15.4%). Patients in the <50% pre-emptive nal-IRI dosing group had a significantly lower incidence of neutropenia and non-neutropenic infection than those in the other groups.

Conclusion:

Our results support the use of nal-IRI + 5-FU/LV as standard clinical practice for treating patients with PDAC based on this large population-based study. Our findings encourage physicians to provide adequate doses of nal-IRI in order to achieve better outcomes without compromising safety profiles.
COVID-19 conspiracy theories and compliance with governmental restrictions: The mediating roles of anger, anxiety, and hope
Authors: Peitz Linus , Lalot Fanny , Douglas Karen , Sutton Robbie , Abrams Dominic
Published: November 2021

The COVID-19 pandemic has been an ideal breeding ground for conspiracy theories. Yet, different beliefs could have different implications for individuals’ emotional responses, which in turn could relate to different behaviours and specifically to either a greater or lesser compliance with social distancing and health-protective measures. In the present research, we investigated the links between COVID-19 conspiracy beliefs, emotions (anger, anxiety, and hope), attitudes towards government restrictions, and self-reported compliant behaviour. Results of a cross-sectional survey amongst a large UK sample ( N = 1,579) provided support for the hypothesis that COVID-19 conspiracy beliefs showed a polarizing relationship with compliant behaviour through opposing emotional pathways. The relation was mediated by higher levels of anger, themselves related to a lesser perceived importance of government restrictions, and simultaneous higher levels of anxiety, related to a greater perceived importance. Hope was also related to conspiracy beliefs and to greater perceived importance but played a weaker role in the mediational model. Results suggest that the behavioural correlates of conspiracy beliefs might not be straightforward, and highlight the importance of considering the emotional states such beliefs might elicit when investigating their potential impact.
Relationship among sleep quality, depressed mood, and perceived social support in older adults: A longitudinal study
Authors: Xu Ran , Lin Yao , Zhang Baoshan
Published: November 2021

Sleep quality and perceived social support (PSS) are acknowledged to play indispensable roles in enhancing the adaptation of later life and improving the health condition and well-being of older adults. Both have received widespread attention from researchers. Some researchers have begun focusing on physical factors or health-related behaviors, such as sleep, that have significant effects on PSS. Good sleep quality has been widely established to be significantly associated with a high level of PSS. However, research on the temporal effects of sleep quality on PSS is limited, and the potential health mechanisms of the relationship between sleep quality and PSS in older adults are mixed. This study aims to investigate the temporal relationship between sleep quality and PSS, including the mediating role of depressed mood in the relationship between sleep quality and PSS in older adults. A total of 281 older adults completed the self-reported questionnaires assessing sleep quality, PSS, and depressed mood at three time-points: at intake, a 6-month follow-up, and a 12-month follow-up. Cross-lagged panel analysis using structural equation modeling indicated that sleep quality at Times 1 and 2 positively predicated PSS at Times 2 and 3, respectively. In addition, the longitudinal mediation analysis showed that depressed mood mediated the effect of sleep quality on PSS. The study found that sleep quality influences PSS through depressed mood in older adults, which enriched the theoretical basis of the field. Findings also offer some practical implications. Particularly for community practitioners, the current findings suggest that improving sleep quality can be a strategy for improving psychological health and social functioning (e.g., PSS) in older adults.
How Frequently and for How Long Do Adults With Type 2 Diabetes Use Management Apps? The REALL Study
Authors: Fisher Lawrence , Fortmann Addie L. , Florissi Caterina , Stoner Keaton , Knaebel Jennifer , Stuhr Andreas
Published: November 2021

Objective:

The objective of the study is to identify predictors of utilization of a type 2 diabetes (T2D) management App over time for insulin users (IUs) and noninsulin users (NIUs).

Research Design and Methods:

We followed over 16 weeks a national sample of unselected T2D adults who independently elected to download and pair a CONTOUR DIABETES App with their CONTOUR NEXT ONE glucose meter. App use and frequency of glucose testing were recorded. Baseline surveys recorded participant demographic, disease status, distress, medication taking, and views of technology to predict utilization.

Results:

Mean age was 51.6 years (108 IUs; 353 NIUs), 48% were female, time with diabetes was 6.9 years, and self-reported HbA1c was 8.1% (36.3 mmol/mol). Mean duration of App use was 85.4 days and 40% stopped using the App before 16 weeks. Continuous users were older and reported higher distress, better medication taking, and more positive attitudes toward technology (all P < .01). IUs tested more frequently than NIUs, but frequency and intensity of testing decreased markedly for both groups over time. More predictors of App use frequency and testing occurred for NIUs than IUs: older age, higher HbA1c, lower distress, more medication taking (all P < .05).

Conclusions:

App use and testing decreased markedly over time. Variations in the predictors of frequency of App use suggest that the utilization of mobile technologies requires a tailored approach that addresses the specific needs of individual users, compared with adopting a one-size-fits-all strategy, and that IUs and NIUs may require very different strategies of customization.
Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes
Authors: Ji Keven S. Y. , Frank-Ito Dennis , Abi Hachem Ralph , Issa Khalil , Johnson Carrie , Mohamedaly Omar , Goldstein Bradley J. , Jang David W.
Published: November 2021

Background

Endoscopic sinus surgery is a well-established treatment for chronic rhinosinusitis in patients with cystic fibrosis, though its benefits seem to be limited to improving sinonasal symptoms rather than affecting lung function.

Objective

This study aims to identify clinical and demographic factors that may influence sinonasal and pulmonary outcomes after surgery.

Methods

This is a six-year retrospective analysis of adult cystic fibrosis patients who underwent endoscopic sinus surgery at a tertiary care center. 22-Item Sino-Nasal Outcomes Test scores and mean forced expiratory volume data at baseline and three to six months after surgery were analyzed using t-test and stepwise regression with the following covariates: age, gender, lung transplant, revision surgery, and pseudomonas on sinus culture.

Results

119 surgeries were performed on 88 patients, with 69% on patients with transplant. The overall mean (Standard Deviation) improvement in 22-Item Sino-Nasal Outcomes Test score was 9.42 (18.15) for the entire cohort ( P < .001). Pseudomonas on culture was associated with less improvement in sinonasal scores ( P = .002). There was no significant change in forced expiratory volume after surgery ( P = .94). Revision surgery ( P = .004) and older age ( P = .007) were associated with less favorable change of pulmonary function on stepwise regression ( P = .002). There was no correlation between change in sinonasal scores and pulmonary function.

Conclusion

Although surgery was associated with a clinically and statistically significant improvement in sinonasal scores in cystic fibrosis patients, patients with pseudomonas may experience less benefit. Revision surgery and older age may be associated with less favorable pulmonary outcomes. Awareness of such variables may help when deciding which cystic fibrosis patients should undergo surgery.
Clinical Replacement Strategies for Meniscus Tissue Deficiency
Authors: Wang Dean , Gonzalez-Leon Erik , Rodeo Scott A. , Athanasiou Kyriacos A.
Published: November 2021

Meniscus tissue deficiency resulting from primary meniscectomy or meniscectomy after failed repair is a clinical challenge because the meniscus has little to no capacity for regeneration. Loss of meniscus tissue has been associated with early-onset knee osteoarthritis due to an increase in joint contact pressures in meniscectomized knees. Clinically available replacement strategies range from allograft transplantation to synthetic implants, including the collagen meniscus implant, ACTIfit, and NUSurface. Although short-term efficacy has been demonstrated with some of these treatments, factors such as long-term durability, chondroprotective efficacy, and return to sport activities in young patients remain unpredictable. Investigations of cell-based and tissue-engineered strategies to treat meniscus tissue deficiency are ongoing.
Surgical strategy for pulmonary sequestration: Focus on precautions for aberrant vessels under minimally invasive surgery
Authors: Nakagawa Tomoki , Wada Atsushi , Aruga Naohiro , Watanabe Hajime , Masuda Ryota , Yamada Shunsuke , Iwazaki Masayuki
Published: November 2021

Background

Recently, thoracoscopic resection of pulmonary sequestration has become more common, since resection of an aberrant artery using an end-stapler is a safe maneuver in many cases. However, injury of the vessels can lead to major hemorrhage. We reported our surgical experience based on thoracoscopic surgery, with five cases of interlobar pulmonary sequestration, focusing on precautions for aberrant arterial vessels.

Object and methods

We performed pulmonary resections for five patients with interlobar pulmonary sequestration in a lower lobe (left, n = 4; right, n = 1) between April 2004 and May 2020. All aberrant vessels were derived from the lower thoracic artery. Two patients had a single aberrant artery and three had multiple. In four patients, these vessels were detected before surgery, and pulmonary sequestration was diagnosed in four. In one elderly patient, the aberrant vessel was overlooked, and lung cancer was suspected before surgery. Angiography or multidetector-row computed tomography was subsequently performed in four cases. The surgical plan was determined according to the location and size of the pulmonary lesion and three-dimensional images of aberrant vessels.

Result

In all patients, approaches were made thoracoscopically. Hemorrhage from an anomalous vessel was encountered in one case. Pulmonary resections included two lobectomies and three limited resections. Angioplasty for the root of anomalous branches was performed following pulmonary resections under converted minimal lateral thoracotomy in two cases.

Conclusion

Preoperative assessment of the anatomical variations in abnormal vessels is essential to achieve safe surgical procedures. According to the situation of the aberrant vessels, selecting surgical procedures with consideration of potential subsequent complications arising over a long period of time is important.
Special issue introduction: Collective redress for the enforcement of labour law
Authors: Rasnača Zane
Published: November 2021

This article introduces the special issue on ‘Collective redress in labour law’. Even the best labour code in the world would be practically useless without procedural rules to enable its enforcement. The contributions in this special issue show that, while the mechanism of collective redress certainly functions with mixed results and often is underused in practice, it is nevertheless a valuable tool in the enforcement toolbox, where available. It might be particularly useful for some groups of workers, such as those who lack individual means for asserting their employment-based rights in their own name. While not an answer to all problems, and undoubtedly, not sufficient to close the justice gap for many European workers on its own, collective redress, if adequately constructed, could complement and improve existing enforcement mechanisms in both national and EU labour law.