bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation-Based Learning to Improve Athletic Trainers’ Knowledge of Exertional Sudden Death Conditions: A Pilot Study
Authors: Winkelmann Zachary , Neil Elizabeth , Games Kenneth , Walker Stacy , Eberman Lindsey
Published: September 2021

Purpose: Continuing education for the practicing clinician typically involves reading peer-reviewed journals and attending professional conferences. These mechanisms do not allow for practice and real-time evaluation of healthcare skills. Simulation-based learning has been widely used in professional education yet is not common in the continued development of the clinician in their lifespan. Method: We used a cross-sectional, repeated measures pilot study. The participants included 11 athletic trainers (age=40±14 years; certified experience=17±14 years) that engaged in a multi-modal continuing professional development session that included a lecture, large-scale simulated learning experience, and debriefing session at a healthcare conference. The outcome measures included 1) a 6-item effectiveness tool to assess the overall program, 2) pre, post, and 6-month follow-up knowledge assessments, and 3) a 6-month follow-up qualitative viewpoint statement. Results: The participants rated the program as effective and useful. On the knowledge assessment, the participants scored an average of 74% on the pre-test and 87% on the post-test with an average change score of a 20.5% increase following the educational session. We identified a significant improvement (P=0.002) in the participants from pre-test to post-test, however a decay in the knowledge improvements from post-test to follow-up at six months (P=0.188) was noted. Conclusion: A multi-modal educational intervention was effective at improving knowledge immediately following the session. This study offers promise that continuing education through simulation may improve knowledge acquisition while serving as a catalyst for clinical practice behavior change.
MATHEMATICAL MODELLING OF VIBRATIONS OF NON-UNIFORM RING-SHAPED ULTRASONIC WAVEGUIDES
Authors:   Belarusian National Technical University, STEPANENKO Dmitry A. , BUNCHUK Ksenija A. ,   State Unitary Innovative Enterprise “Science and Technology Park of BNTU “Polytechnic”
Published: September 2021

The article describes technique for modelling of ultrasonic vibrations amplifiers, which are implemented in the form of non-uniform ring-shaped waveguides, based on application of harmonic balance method. Bending vibrations of the waveguide are described by means of non-uniform integral and differential equations equivalent to Euler–Bernoulli equations in order to simplify calculation of amplitude-frequency characteristics of vibrations, particularly, to exclude the need of working with singular matrices. Using harmonic balance method, equations of vibrations are reduced to overdetermined non-uniform linear system of algebraic equations, which least-squares solution is determined by means of pseudo-inverse matrix. On the basis of analysis of numerical example possibility of existence of variable-sign and constant-sign vibration modes of the waveguide is shown and it is determined that for realization of amplifying function it is necessary to use waveguide at constant-sign vibration mode. The constant-sign vibration modes are combinations of bending defor-mation and extensional deformation of central line of the waveguide and they are detected due to accounting extensibility of the central line in equations of vibrations. Validity of the obtained results is confirmed by comparing them to the results of modelling by means of finite element method.
Impact of Network Factors on Supply Chain Performance: A Case of Textile Sector of Pakistan
Authors: Hassan Nadir Munir , Abbasi Muhammad Nauman
Published: September 2021

This study elaborates the importance of network perspective in driving performance outcomes especially in the context of agriculture (Textile) supply chains. The impact of network factors (i.e. actors, resources, and activities) on overall supply chain performance have been explored. By deploying survey, a two-stage cluster sampling was used to attain study objectives. The Textile firms from Punjab and Sindh were selected for data collection. Through a structured questionnaire, 482 responses were generated and analyzed using PLS-SEM. The findings of the study confirmed that Network Actors (Textile Firms), the activities they perform, and the resources they have, generate a significant and positive impact on supply chain performance. The study recommends the need for understanding the role of integrative initiatives between the studied variables, i.e. network factors. Further, it is argued that integrated Network Factors can generate a significant impact on Supply Chain Performance.
KINERJA RUAS JALAN TAMAN - KEGANTERAN SEBAGAI FUNGSI AKSESIBILITAS DAN MOBILITAS WILAYAH
Authors: Artiwi Nila Prasetyo
Published: September 2021

Jalan Taman – Keganteran menurut klasifikasi sistem jaringan jalan, termasuk jalan lokal sekunder .Memiliki panjang jalan ± 4.250 m, lebar 3,5 m, terdiri atas 2 lajur 2 arah (2/2 UD), bahu jalan 0,5 m tidak merata sepanjang jalan, saluran drainase tersedia tidak merata sepanjang jalan. Jalan tidak dapat dilalui oleh kendaraan roda empat secara berpapasan. Penelitian untuk mengetahui kinerja jalan  dan tingkat pelayanan Jalan Taman – Keganteran. Survey Lalu lintas menghitung langsung arus lalu lintas pada hari kerja dan hari libur. Metodologi Kuantitatif Deskriptif dengan pengolahan data primer menggunakan aplikasi Excell. Total volume lalu lintas 1.032 smp/ jam, tingkat pelayanan ruas jalan pada tahun 2020 adalah “B”, Derajat kejenuhan (DS) jalan 0.4973 ≤ 0.54. Diperkirakan pertumbuhan lalu lintas 5% per tahun,  maka pada tahun 2030 ruas jalan Taman – Keganteran mencapai derajat kejenuhan, 0.8101 dengan tingkat pelayanan “D”. Pada tahun 2030  sudah mengalami kemacetan. Memasuki tahun 2033, kinerja ruas jalan sudah tidak memenuhi pelayanannya terhadap fungsi jalan. Saran yang dapat diberikan oleh penulis adalah ruas Jalan Taman – Keganteran sangat layak untuk mendapatkan penanganan berupa pelebaran jalan dan pembetonan (rigid pavement). Setelah dilebarkan menjadi 7 m dengan lebar bahu jalan 1,5m, akan memiliki tingkat pelayanan “A” dan berpotensi meningkatkan aksesibilitas dan mobilitas masyarakat .
Barter Sistemi: Türkçe Literatürde Yapılmış Çalışmalar Üzerine Bir İnceleme
Authors: KESKİN Ömer , AYTEKİN Yunus Emre
Published: September 2021

Barter sistemi, Türkçe literatürdeki çalışmaların özellikle bazılarında hem bütünüyle tutarsız bir terminoloji kullanılarak hem de kendine özgü bazı yönleriyle doğrudan bağdaştırılamayacak çıkarımlarda bulunularak açıklanmıştır. Bu çalışmanın amacı, barter sistemi ile ilgili yapılmış bazı çalışmalardaki açıklamaları inceleyerek, sistemle doğrudan bağdaştırılamayacak noktaları tespit edip bu noktaları eleştirel bir bakış açısıyla değerlendirmek suretiyle teorik açıdan Türkçe literatüre katkı sağlamaktır. Bu bağlamda, çalışma kapsamında ilk önce barter sistemi, bütünüyle daha tutarlı olacağı düşünülen bir terminoloji kullanılarak açıklanmıştır. Daha sonra, barter sistemi ile ilgili yapılmış bazı çalışmalardaki açıklamalar incelenerek, sistemle doğrudan bağdaştırılamayacak noktalar tespit edilmeye çalışılmıştır. Son olarak, tespit edilen noktalar, bulgular başlığı altında kategorilere ayrılmış ve tek tek yorumlanmıştır. Çalışmanın sonucuna göre, incelemeye tabi tutulan açıklamalar, genel anlamda barter sisteminin kendine özgü hukuki mahiyeti ve kredilendirme ilkesiyle tam anlamıyla uyuşmamaktadır.
The Influence of Leadership Styles and Work Motivation on Employees Performance of Islamic Banks
Authors:   Faculty of Islamic Economic and Business, Universitas Islam Negeri (UIN) Datokarama Palu, Bachmid Sofyan
Published: September 2021

This paper aims to determine the influence of leadership style and work motivation on employee performance at Bank Mandiri Syariah Palu Indonesia. This study employed a quantitative study, and the data were collected through a survey. There were 48 samples in this study. We used the saturation sampling technique to determine the samples because all populations were recruited for the samples. The data were analyzed using multiple linear regression analysis. The results show that leadership style and work motivation simultaneously affect employee performance at the Bank Mandiri Syariah Palu Indonesia. Among those variables, leadership style has a more significant effect on employee performance. In contrast, work motivation has less influence on employees' work performance, but it still plays a role in the employees' work performance. Our study contributes to better strategy in managing leadership and works motivation to enhance employees' work performances within Islamic banking industries.
Strengthening The Corruption Eradication Commission as an Institution at The Forefront of Law Enforcement on Corruption in Indonesia
Authors:   Universitas Pembangunan Nasional Veteran Jakarta, Susastyo Damian Adhi
Published: September 2021

The Corruption Eradication Commission (KPK) has broad duties and authorities in the prevention and prosecution of corruption with the functions of investigation, investigation and prosecution. In Law Number 30 of 2002 Article 6 states that the Corruption Eradication Commission has the following duties: a. Coordination with agencies authorized to do eradicate criminal acts of corruption; b. Supervision of agencies authorized to do eradicate criminal acts of corruption; c. Carry out investigations, investigations and prosecutions of criminal acts of corruption; d. Taking steps to prevent criminal acts of corruption; and e. Monitor to the implementation of government. However, over time since its to establish, regulatory reviews of the KPK have continued to be carried out, given the increasing number of judicial reviews in the Constitutional Court regarding the position and authority of the KPK. Apart from the pros and cons, as part of the most important agenda in reforming governance in Indonesia, the presence of the KPK was motivated by the low level of public trust in law enforcement agencies (the Attorney General's Office and the Police) at that time in eradicating corruption. On the other hand, especially during the 17 years of Law Number 30 of 2002, there have been many changes in conditions, so the revision of the KPK Law is deemed necessary to determine whether efforts to eradicate corruption are in accordance with the objectives of establishing the KPK. Whether the reason for evaluating and revising the authority of the KPK is seen as a form of strengthening or weakening the Corruption Eradication Commission (KPK), is the basis for this research being carried out.
Nature of Conflicts and Their Resolution in Korogocho Slums, Nairobi, Kenya
Authors:   University of Nairobi, Kinyua Judy Wathata
Published: September 2021

Majority of the households in slums are female headed and have very low incomes. Survival for these women exposes them to illegal income generating activities including prostitution, hawking and making illegal local brews. This results in conflicts not just among themselves for competition over the shared resources but also with the law enforcement agencies. The study sought to establish the nature of conflicts prevalent in Korogocho slum, Nairobi Kenya. The study employed the Liberal Feminism Theory to conceptualize and analyze the nature of conflicts and focused on two ideals, equality and liberty to explain the consequence of the push factors leading women into slum life. The study respondents were women, local administrators and leaders, village elders, clinical staff and officers from Civil Society Organizations selected through simple random sampling procedure and purposive sampling. Data was collected using a standard questionnaires with both open and closed ended items. There was also a focused groups and key informants interviews. Quantitative data was exported to Statistical Package for Social Science (SPSS) while qualitative data was thematically analyzed. Findings showed that most of the conflicts were: over competition for scarce resources. The conflicts resulted in physical battery. The slum vigilante groups led in the resolution of the conflicts with limited police intervention. Given that the groups were male dominated, women got little justice. The study recommends the need for the government and development partners to build inclusive community agencies to identify and respond to the common problems facing women in the slums instead of leaving the slum residents to solve them on their own.
Effect of Service Quality on Consumer Satisfaction at the Jakarta Claim Center Division Pt. Wahana Tata Insurance
Authors:   Lecture at University of Faletehan Banten, Indonesia, Kusuma Hero Wirasmara
Published: September 2021

This study aims to determine the significant positive effect simultaneously and partially between the independent variables: the quality of service consisting of physical evidence, reliability, responsiveness, assurance, and empathy for the dependent variable, namely customer satisfaction at the Jakarta Claim Center Division of PT. Wahana Tata Insurance. System. The sample in this study was 100 consumers in the Jakarta Claim Center Division of PT. Wahana Tata Insurance. Furthermore, the sampling technique used in this study is "Simple Random Sampling" for respondents who are currently carrying out the process of filing claims at the JCC Division of PT. Wahana Tata Insurance. Data collection was done by using a questionnaire technique. Simultaneous research results quality of service (physical evidence, reliability, responsiveness, assurance, and empathy) have a positive, solid, and significant effect on customer satisfaction. Partially, physical evidence, reliability, responsiveness, and empathy have a positive, relatively strong, and significant effect on customer satisfaction at the Jakarta Claim Center Division of PT. Wahana Tata Insurance.
How Motivation, Competency, and Working Environment Affect Employee Performance in Indonesian Private University
Authors:   Politeknik Pajajaran ICB, Bandung, Indonesia, Pringgabayu Dematria
Published: September 2021

The purpose of this study to determine: 1) Motivation, Competence, Work Environment and Performance of Employees in Private-owned Politechnic; 2) to determine the effect of motivation on Employee Performance, 3) to determine the effect of Competence on employee performance; 4) to determine the effect of Work Environment Employee Performance; 5) to determine the effect of Motivation, Competence and the Work Environment simultaneously on Employee Performance Politeknik Swasta. The method is a method of research used census (population) of 35 respondents using descriptive analysis and verifikatif. From the results of descriptive analysis showed that the total effect of motivation (X1) of the Employee Performance (Y) of 63.3%, the total effect of Competency (X2) of the Employee Performance (Y) of 14.8%, and the total effect of Work Environment (X3) Performance of Employees (Y) of 7.7%. While the influence of Competence, Motivation, Corporate Culture of Performance jointly or simultaneously have the effect of a total of 85.8%.
Na real presença de Vossa Magestade!:A administração de Manoel Tovar no Espírito Santo (1804-1812)
Authors: Carvalho Enaile Flauzina , Oliveira Ueber José de
Published: September 2021

Quando Manoel Vieira da Silva de Albuquerque e Tovar assumiu a administração do Espírito Santo, entre 1804 e 1812, sua missão foi dar continuidade ao projeto de inserir a capitania na lógica de desenvolvimento do Estado português, numa conjuntura, inaugurada na última década do século XVIII, marcada pela inserção de acadêmicos nos postos chave da administração colonial. A missão do governador era gerar formas de exploração da terra, tendo como base estudos científicos, com o propósito de atender demandas da Metrópole, mesmo que isso significasse desconsiderar a estrutura socioeconômica já constituída no território capixaba, ao longo dos séculos coloniais, caracterizada pela dinâmica comercial envolvendo o abastecimento interno e o uso da cabotagem costeira. O presente artigo busca compreender o período de Manoel Tovar no Espírito Santo, considerando as instruções enviadas pela Coroa e o posicionamento das elites locais quanto aos rumos da administração do governador. Para tanto, a pesquisa envolve a análise qualitativa de documentos oficiais e de cunho privativo, objetivando analisar a passagem do personagem histórico em epígrafe pelas terras espírito-santenses.
Effect of sulphur and zinc management on yield, quality and nutrient uptake in pearl millet (Pennisetum glaucum) – lentil (Lens culinaris) crop sequence
Authors:   Department of Agricultural Chemistry and Soil Science, Raja Balwant Singh College Bichpuri, Agra (U.P.) 283 105, YADAV KAUSHAL
Published: September 2021

A field experiment was conducted at Panwari village of Agra district during Kharif and rabi season of 2015-16 and 2016-17 to study the effect of sulphur and zinc management on yield, nutrient uptake and residual soil fertility under pearl millet (Pennisetum glaucum) – lentil (Lens culinaris Medikus) crop sequence. Four levels each of sulphur and zinc were evaluated under randomized block design with three replications. Both the nutrients were applied to pearl millet and their direct and residual response was ascertained to pearl millet and lentil in sequence. Pooled results indicated that grain and stover yield of pearl millet improved significantly with increasing levels of S up to 20 kg S ha-1 over control. An increase of 17.0 and 16.5 % in grain and stover yield was recorded with 20 kg S ha-1 over control. Similarly, grain and stover yield of pearl millet increased significantly with Zn and maximum grain (3.46 t ha-1 ) and stover (8.19 t ha-1 ) yields were recorded with 4 kg Zn ha-1 . The content and yield of protein in both the crops increased significantly with the addition of S and Zn over control. The residual effect of S in lentil was significant at 40 kg S ha-1 and grain and straw yield increments were to the extent of 18.6 and 15.8 per cent, respectively. The residual effect of 6 kg Zn ha-1 on succeeding lentil crop produced 16.7 and 14.0 % higher grain and straw yield over control, respectively. Application of S and Zn showed significantly beneficial effect on S and Zn uptake by pearl millet and succeeding lentil crop over control. Nitrogen and P uptake by both the crops also improved significantly with these elements over control
Bu günah kimin boynuna? Diyarbakır anneleri
Authors: Kalafat Yaşar
Published: September 2021

Türkiye Cumhuriyeti, Resmi milli dilin Türkçe olduğunu esas alırken, Türkiye Cumhuriyeti halkı arasında anadilleri Türkçe olmayan Kürtçe gibi dillerin de lehçeler ile varlığını kabul etmiş olmalıdır. Zira, bu kabulün kapsamında Türk dili incelemeleri için kurulmuş olan Türk Dil Kurumunun Kürtçe-Türkçe ve Türkçe-Kürtçe sözlük yayınlarını da faaliyet alanı kapsamına alarak göstermiştir.
Resmi dilin Türkçe olduğu değiştiremeyeceği hükmüne rağmen Türkiye’de Türkçeye alternatif dillerin oluşması, bazı dillerin eğitim dili olarak geliştirildiği görülmektedir. Mesela Anadili Arapça olan Türkiye’deki Suriyeliler eğitimlerini Büyük ölçüde, Arap eğitmenlerden, Arap müfredatı ve eğitim araçlarından hareketle almaktadırlar. Miktarları milyonlarla anlatılan sığınmacıların “anadil” anlayışı farklıdır ve bu anlayış farklılığı ilgili maddelerle çelişki içermektedir.
Bu çalışmada Diyarbakır Anneleri adı altında bir platform oluşturan grup üzerinden ayrı bir Kürt kimliği yaratmak istenmesinin yanlışlığını bin yıllık birlikteliği bozma girişimi olduğunu ve siyasi oryantalistlerin amaçlarına hizmet ettiğini ortaya koymaya çalışacağız.
Pengaruh Profesionalisme Aparatur Terhadap Kualitas Pelayanan Publik Bidang Administrasi Pemerintahan
Authors: Amin Muhammad
Published: September 2021

The purpose of this study was to determine the extent of the influence of professionalism of the apparatus on the quality of public services in the field of government administration at the Kairatu subdistrict office, West Seram district (Studies on the Waimital Village Community, Kairatu district). The method used in this research is descriptive method with a quantitative approach. The population of this research is 40 people. The results show that after identifying the research variables, it is known that the distribution of respondents' answers to all independent variables is quite varied, but on average they are in the good category. Meanwhile, the condition of public service quality that was perceived by respondents (service users / customers) was also in the good category, but training was not satisfactory. Partially, aspects of the professionalism of urban village officials have a positive and significant influence and have a contributive relationship to the quality of public services.
Efektifitas Implementasi Kebijakan Kurikulum 2013 pada Satuan Pendidikan di Kota Ambon dan Kabupaten Maluku Tengah
Authors: Matdoan Muhammad Nur
Published: September 2021

The purpose of this study was to determine: 1) the effectiveness of 2013 curriculum planning in educational units (SD / MI, SMP / MTs, SMA / MA, SMK) in Ambon City and Central Maluku Regency 2) the effectiveness of 2013 curriculum development in educational units in Ambon City and Central Maluku Regency 3) the effectiveness of the 2013 curriculum implementation in the education units of Ambon City and Central Maluku Regency. This type of research is descriptive qualitative using unstructured interview guidelines for data collection purposes with 42 informants.

The research results are; The education unit in carrying out the planning, both the education unit and the education and culture office, has formed a curriculum development team (TPK) in Ambon City whose steps are; (1) for the city level, the team works to provide material in the form of training to school principals, supervisors, teacher working groups (KKG) and subject teacher deliberations (MGMP) and holds workshops for guiding teachers, especially in the context of efforts to increase teacher competence. (2) The parties involved in the curriculum development team consist of; school committees, education boards, education offices, professional associations, school principals, the world of industry and the world of work (DUDI), natural resources and socio-culture, all work together to monitor and evaluate to validate the curriculum documents that have been made.
Strategi Mendorong Kinerja dengan Meningkatkan Komunikasi Interpersonal dan Komitmen Organisasi
Authors: Latupapua Conchita Valentina
Published: September 2021

Komunikasi Interpersonal adalah proses komunikasi yang terjadi antara dua orang atau lebih dan terjadi timbal balik secara langsung. Sedangkan Komitmen Organisasi adalah derajat dimana karyawan ingin terus berpartisipasi secara aktif dalam organisasi tersebut.Tujuan Penelitian ini adalah untuk mengetahui seberapa besar Pengaruh Komunikasi Interpersonal dan Komitmen Organisasi.

Penelitian ini menjelaskan hubungan antar variable secara parsial dengan metode pengambilan sampel dengan metode sensus terhadap 37 pegawai Balai Proteksi Pertanian dan Peternakan Provinsi Maluku.Metode analisis yang digunakan adalah analisis regresi linear berganda. Dari hasil pengujian ini diperoleh Pengaruh Komunikasi Interpersonal ( X1 ) dan Komitmen Organisasi ( X2 ) Variabel dependen yaitu Kinerja Pegawai ( Y ) .

Hasil Penelitian ini menunjukan bahwa Semaikin baik pegawai membangun dan meningkatkan komunikasi interpersonal dan Komitmen Organisasi maka akan semakin meningkatkan kinerja pegawai.
Dampak Lingkungan Kerja dan Etos Kerja Terhadap Kinerja Pegawai
Authors: Dolonseda Herman Philips , Watung Sjeddie R
Published: September 2021

This study aims to determine the effect of work environment and work ethic on employee performance in the Regional Education and Culture Office of Sangihe Islands Regency. This study used a survey research method, where the research instrument was a tested questionnaire and met the validity and reliability test requirements. Data were analyzed using multiple regression analysis. The population in this study were all employees at the Education and Culture Office of the Sangihe Islands Regency totaling 70 people, while the number of samples was 60 people. The results show that there is an influence of the work environment on the performance of employees at the Regional Education and Culture Office of the Sangihe Islands Regency, there is an influence of work ethic on the performance of employees at the Regional Education and Culture Office of the Sangihe Islands Regency, and there is a joint influence on the work environment and work ethic on the performance of employees at the Regional Education and Culture Office of Sangihe Islands Regency.
Profil Pranata Sosial Komunitas Suku Nuaulu
Authors: Manuputty Anike J. M. , Nahuway Lodewyk
Published: September 2021

ABSTRACT

Social institutions are rules that apply in regulating human behavior in acting based on considerations of norms and values ​​that live in the life of society. This study aims to determine the existence and benefits of socio-cultural institutions in the Nuaulu tribe community. Data collection techniques with observation and in-depth interviews. Research informants came from elements of the state government, traditional leaders, youth leaders, educators and community leaders.

The results of the data analysis concluded that hereditary customs strongly influenced the life of the Nuaulu people with the loyalty of the people in carrying out the prevailing institutions. The economic system and the community's livelihood system are farming, processing sago, gathering and laboring. The socio-cultural institutional arrangements are in the form of an adult ceremony for boys (Brokeneri), an adult ceremony for girls (pinamou), a wedding ceremony, a pregnancy ceremony, a birth ceremony, a haircut ceremony (tihtikuau) and a funeral ceremony. The structure of the kinship system is a patrilineal (male lineage) and it is not required to have intermarriage. Religious institutions and beliefs are tribal religions. Educational institutions, knowledge, and technology are based on experience (local knowledge) from generation to generation, and children of school age have attended various levels of education to tertiary education.

 Keywords: Social Institutions, Nuaulu Tribe Community.
CONTAGEM DE PLAQUETAS NA ADMISSÃO COMO PREDITOS DE MAIOR GRAVIDADE EM PACIENTES HOSPITALIZADOS POR COVID-19
Authors: Cruz Gustavo Alexandre , Liberato Érica Letícia Angelo , Gregorio João Paulo , Anibal Fernanda de Feitas , Roscani Meliza Goi
Published: September 2021

Introdução: Mesmo com o progresso gradual na área fisiopatologia e dos fatores relacionados ao prognóstico em pacientes com COVID-19, contudo não se sabe ainda se a contagem de plaquetas no plasma nestes pacientes pode ter uma correlação com o pior desfecho clinico, como óbito durante a internação na fase aguda da doença. Objetivos: O objetivo desse estudo foi avaliar quais fatores de risco e marcadores laboratoriais correlacionados ao pior prognóstico clinico, o óbito e com a contagem de plaquetas do plasma pacientes hospitalizados por COVID-19 em hospital universitário Métodos: Estudo clínico prospectivo observacional em pacientes hospitalizados por COVID-19 com mais de 18 anos internados em hospital universitário. Todos os pacientes incluídos foram avaliados quanto a sintomas e exames laboratoriais nas primeiras 24 horas e fatores de risco para doença cardiovascular (DCV). Análise estatística foi realizada para avaliar quais fatores se associaram ao desfecho óbito durante a internação. Resultados: Foram avaliados 104 pacientes internados consecutivamente pela doença no período de agosto a dezembro de 2020, com idade média de 6218 anos, sem diferença entre sexo, média de 113 dias de internação, média de dias de sintomas no momento da internação de 103 sendo que 49% precisaram de UTI e 18% faleceram. A amostra apresentou 44% de hipertensos, 14,4% com DCV conhecida e 23% de diabéticos. Nenhum fator de risco ou sintoma na admissão se associaram a maior mortalidade. Em 67 pacientes que apresentaram todos os exames, os fatores que se associaram a maior mortalidade foram idade (p=0,001) e contagem de plaquetas (p=0,002) na admissão. Nem dímero D, troponina ou PCR foram associados à gravidade pela doença. O valor de corte de contagem de plaquetas 156000 mm 3 apresentou sensibilidade de 22% e especificidade de 82% para mortalidade, com área sobre a curva de 0,75 [IC: 0,63-0,87; p=0,002). Conclusão: Grande parte dos marcadores não teve relação com a alta taxa de mortalidade, contudo a contagem de plaqueta no limite inferior da normalidade no momento da internação apresentou especificidade de 82% para desfecho desfavorável: óbito. Além disso, o fator idade teve uma relação com o pior prognóstico em pacientes internados.
BIOLOGIA DO ENVELHECIMENTO
Authors: Ferreira Carlos Eduardo Gomes , Costa Matheus Antonio Pereira , Carvalho Rafael Leite , Oliveira Adriana Sarmento De
Published: September 2021

Introdução: Ao longo dos anos, mudanças na qualidade de vida vêm impactando diretamente a expectativa de vida humana. Estudos apontam certo envelhecimento mundial. Isso indica a importância de pesquisar a relação do impacto das atividades físicas no organismo e no envelhecimento, principalmente a nível celular, como em estruturas celulares consideradas possíveis marcadores: os telômeros. Compostos por uma curta e repetitiva sequência de DNA rica em guanina (5’-TTAGGG-3’)n, têm a função de proteger a integridade do DNA e a informação genética. Contudo, os telômeros são encurtados a cada ciclo celular, logo, acredita-se que estejam ligados ao envelhecimento biológico e senescência da célula. Para contornar tal situação, algumas células possuem a telomerase, enzima capaz de sintetizar DNA telomérico através de transcriptase reversa. Objetivos: Familiarizar o leitor com a questão atual dos telômeros, fornecendo informações atualizadas e integradas sobre a sua estrutura e função e a possível relação da prática de atividades físicas com seu comprimento e o envelhecimento, além de debater possíveis mecanismos de ação. Metodologia: Revisão bibliográfica a partir dos bancos de dados PubMed, MEDLINE e LILACS, adotando os seguintes indexadores, em diferentes combinações: telomere(s), telomerase, exercise, physical activity, aging, elderly. E a partir de artigos pré-selecionados foi realizada uma lista de referências. Resultados: A maioria dos estudos alega a associação entre a atividade física e o aumento do comprimento dos telômeros em idosos. No caso de jovens não há diferença significativa. Achados revelam telômeros, em média, 200 pb mais longos em indivíduos idosos que treinavam do que os sem treinamento. Estudos sugerem que atividade física moderada apresenta um efeito protetor no comprimento dos telômeros de leucócitos. Porém, a prática de exercícios de modo intenso possui efeito contrário na proteção dos telômeros. Ou seja, atividades físicas tanto em níveis baixos quanto em altos podem ser fatores que, em longo prazo, favorecem o encurtamento dos telômeros de leucócitos. Conclusão: Alguns estudos apresentam certa limitação, pois os dados sobre atividade física foram autorrelatados, podendo ser tendenciosos. E a inconsistência entre as pesquisas pode ser atribuída às diferentes etnias das amostras, aos métodos utilizados e a outras variáveis não levadas em consideração.
VACINAS CONTRA SARS-COV-2: ALVOS MOLECULARES E MECANISMOS DE AÇÃO
Authors: Rodrigues Maria Luíza Ferreira , Souza Felipe Oliveira Fernandes De , Camargo Kaendra Almeida Vale De , Modesto Lucas Fernandes , Gremski Luiza Helena
Published: September 2021

Introdução: A pandemia do SARS-CoV-2 (Coronavírus 2, causador da Síndrome Respiratória Aguda Grave) tornou-se um grande desafio na área da saúde, pela alta taxa de transmissão viral e letalidade significativa. Nesse contexto, o desenvolvimento de vacinas eficazes é essencial como abordagem decisiva para o controle da mortalidade e da própria pandemia. Assim, é necessário o entendimento de alguns princípios imunológicos, entre eles o mecanismo de ação e os alvos moleculares das vacinas, bem como o conhecimento do vírus e sua estrutura, principalmente suas proteínas “spike” (cuja função é mediar a entrada na célula hospedeira). Objetivos: Realizar um levantamento bibliográfico referente às vacinas disponíveis e em desenvolvimento contra o SARS-Cov-2, destacando seus mecanismos de ação e alvos moleculares no processo de resposta imunológica. Material e métodos: Foi realizada uma revisão de literatura incluindo artigos em inglês relacionados ao desenvolvimento das vacinas contra o SARS-Cov-2, com ênfase nos aspectos imunopatológicos, publicados desde 2020. Como ferramenta de busca foi utilizada a base de dados eletrônica National Library of Medicine, utilizando-se os descritores: “COVID-19”; “Immune response”; “Immunopathology”; “SARS-CoV-2” e “Vaccines”. Resultados: Diversos mecanismos de ação foram estudados no desenvolvimento dessas vacinas. Vacinas de mRNA utilizam a transcrição e tradução, respectivamente, de glicoproteína S, S do tipo selvagem e proteínas estruturais S, M (membrana) e E (envelope) como antígenos do vírus para desencadear a resposta imunológica. Vacinas de Partículas Semelhantes a Vírus (Virus-Like Particles - VLPs) são estruturas proteicas que imitam a estrutura do vírus real sem capacidade infecciosa, induzindo resposta imune por meio da ativação células B ou T, com envolvimento de células T citotóxicas CD8+. Vacinas de vetores não replicantes utilizam comumente o vetor adenoviral para gerar respostas imunes humoral e celular. Há, também, vacinas à base de proteína recombinante e aquelas envolvendo o patógeno atenuado vivo, esta última promove a mesma resposta imune anterior. Por fim, vacinas inativadas utilizam inativação completa ou morte do patógeno para produção de anticorpos contra determinantes antigênicos de glicoproteína hemaglutinina na superfície do vírus. Conclusão: O desenvolvimento de vacinas contra COVID-19 caracterizou-se pelo aprimoramento biotecnológico, pois mecanismos citológicos foram estudados como fator imunológico.
REVISÃO: DOENÇA DE PARKINSON E SUAS ETIOLOGIAS MITOCONDRIAIS
Authors: Zamprogno Nathália Perini , Novaes Maria Angélica Santos
Published: September 2021

Introdução: A doença de Parkinson (DP) apresenta etiologia multifatorial, que inclui disfunções genéticas e ambientais. Resulta da perda progressiva de células produtoras de dopamina na substância negra e do acúmulo de proteínas, principalmente a alfa-sinucleína (SNCA), nos corpos de Lewy. Esses aspectos levam a sintomatologia de bradicinesia, tremor de repouso e rigidez. Neurônios dopaminérgicos necessitam de demanda energética, assim, distúrbios mitocondriais, como bioenergéticos, mutações no DNA nuclear ou mitocondrial, alterações no transporte, movimento e morfologia dessa organela, estão associados à DP. Objetivo: Esclarecer a relação de distúrbios mitocondriais e o desenvolvimento da DP. Materiais e Métodos: Revisão bibliográfica da literatura realizada na bases de dados PubMed/MEDLINE, durante abril e maio de 2021, por meio do cruzamento dos descritores, cadastradas no DeCS, “Parkinson Disease” AND “Mitochondria”. Foram incluídos artigos com textos disponíveis completos gratuitamente, publicados nos últimos cinco anos, em inglês e português, com o estudo envolvendo humanos e excluídos aqueles cujo título ou resumo eram incoerentes com a linha de interesse da atual revisão. Com base nisso, encontraram-se 106 artigos, dos quais 8 foram selecionados, além de outros 2 e um livro didático, julgados importantes para a discussão do tema. Resultados: Evidências científicas mostram que mutações nos genes SNCA, LRRK2, Parkin e PINK1 implicam em mecanismos mitocondriais deficitários que desenvolvem a DP. A mutação do gene SNCA sensibiliza neurônios ao estresse oxidativo e provoca danos por toxinas, o que induz a fragmentação mitocondrial e a produção de radicais livres. A PARKIN previne o edema e a ruptura mitocondrial secundária à toxicidade, ou seja, relaciona-se à integridade mitocondrial. Alterações na proteína PINK1 interferem no potencial da membrana mitocondrial. Ademais, mutações na quinase LRRK2 interferem no tráfego mitocondrial e nas proteínas da membrana externa. Logo, modificações nesses genes além de diminuírem a atividade do complexo I da cadeia transportadora de elétrons, prejudicam a produção energética, a regulação da síntese de dopamina e sua neurotransmissão. Conclusão: De acordo com a literatura, observa-se a fundamental relação entre DP e disfunções mitocondriais, todavia mais estudos são necessários para esclarecer e justificar tal abordagem, como forma de melhorar o prognóstico e a terapêutica.
ALTERNATIVAS FARMACOLÓGICAS PROMISSORAS PARA O TRATAMENTO DA LEISHMANIOSE
Authors: Silva Thallys Mendes da , Oliveira Eduardo Felipe Da Silva , Sousa Maria De Fátima De , Farias Vitória Denise Soares , Santos Gleyka Daísa De Melo
Published: September 2021

Introdução: A leishmaniose é um complexo de doenças ocasionadas por protozoários do gênero Leishmania, que ainda caracteriza-se como emergente e sem controle, com uma incidência anual de 1,5 a 2 milhões de casos. Dentre as opções de tratamento existentes, a farmacoterapia é a mais ideal, entretanto, limitada, pois a maioria destas drogas apresentam elevada toxicidade e ocasionam efeitos adversos graves. Assim, impulsionando a busca por fármacos mais efetivos e menos tóxicos. Objetivos: Apresentar novas farmacoterapias promissoras no tratamento da leishmaniose. Material e métodos: Trata-se de uma revisão de literatura produzida a partir da análise de estudos científicos no idioma inglês, publicados entre os anos de 2018 e 2021. A pesquisa foi realizada nos bancos de dados ScienceDirect e LILACS, utilizando os descritores: “leishmania potential drugs”, “anti-leishmania drugs” e “leishmanicidal activity”. Inicialmente, dos 621 estudos encontrados nas bases de dados, vinte foram selecionados para leitura e fichamento, dos quais, o total de dez enquadraram-se no tema, por contemplarem de forma concisa os objetivos da revisão. O critério de exclusão, por sua vez, foi a não correlação direta dos artigos com os objetivos do trabalho. Resultados: As recentes pesquisas têm apresentado inúmeras alternativas terapêuticas promissoras para o tratamento da leishmaniose, por meio de fármacos projetados com base em moléculas de atividade já conhecida, porém de maior atividade e menor potencial tóxico. Neste sentido, derivados indol-tiossemicarbazonas demonstraram efeitos leishmanicidas, após levar o parasita à inviabilidade celular e exibir baixa citoxicidade em células animais. Ensaios envolvendo um derivado quinolina, por sua vez, apresentaram uma redução significativa na carga parasitária, além de baixos níveis de toxicidade e propriedades farmacocinéticas adequadas. Além disso, diferentes estudos envolvendo complexos metálicos ligados a trimetroprima e diclofenaco, apontaram considerável atividade leishmanicida e menor citotoxicidade, para ambos os candidatos. A literatura relata ainda, a existência de incontáveis outras moléculas em análise, que possuem o conjunto de critérios necessários para sua aplicação como agentes anti-leishmania. Conclusão: As evidências sugeriram que existem diversas possibilidades de novos fármacos leishmanicidas que apresentam efetividade e segurança, o que, só reforça a necessidade do desenvolvimento destes estudos para definir melhorias nos tratamentos da doença.
An analytical study of the different methods of handling informal areas on state property “Case study of the informal unsafe areas near the railway on Sudan street, Giza”
Authors:   Civil and Architectural Constructions Dept., Faculty of Technology and Education, Suez University, Egypt., Serry Azza , Mohamed Sherif ,   Civil and Architectural Constructions Dept., Faculty of Technology and Education, Suez University, Egypt., Amin Mohamed ,   Civil and Architectural Constructions Dept., Faculty of Technology and Education, Suez University, Egypt., Mabrouk Youssef ,   Civil and Architectural Constructions Dept., Faculty of Technology and Education, Suez University, Egypt.
Published: September 2021

The problem of informal areas in Egypt, despite the difference in these informal areas in terms of location, area, population and the quality of services, they share their suffering from rising population density, insufficiency of basic facilities and services, the spread of environmental pollution and low standard of living. The importance of this research lies in a new problem that hinders planning and executive authorities in the development of informal areas, which is land ownership. This comes in different entities such as private property whither for residents or companies, and central authorities such as the Ministry of Endowments, Railway Authority, State Property, or the Antiquities Authority. the research exposes all of this to reach results and solutions that help the planning and executive authorities in providing services to these areas, and in the implementation of vital projects and development projects.
Evaluation of anxiolytic and anticonvulsant potential of Mirabilis jalapa ethanolic extracts on standardized rat models
Authors:   Vinayaka Mission’s College of Pharmacy, Salem-636008, India., Kumar M. , Thamotharan G. ,   Vinayaka Mission’s College of Pharmacy, Salem-636008, India.,   J.K.K.MMRF’S Annai J.K.K.Sampoorani Ammal College of Pharmacy, Komarapalayam, India., Revathi P. ,   Kongunadu Arts and Science College, Coimbatore-641 029, India., Shyji S. ,   J.K.K.MMRF’S Annai J.K.K.Sampoorani Ammal College of Pharmacy, Komarapalayam, India.
Published: September 2021

Anxiety and Convulsion are the most prominent, crippled and cruel neurological diseases in recent times. There are many indigenous plants have beneficial properties to treat mental disease and psychic complaints. Evaluation of anxiolytic and anticonvulsant activity of leaf and root ethanolic extracts of mirabilis jalapa in rat models were carried out using standardized experimental methods. The dried leaves and root was macerated with ethanol separately and administered the discern dose of 200 mg/k g p.o. and 400mg/kg p.o. from each extract and employed in Elevated Plus Maze test (EPM) and Open field test (OFT) with 2mg/kg i.p of Diazepam as a standard drug to assess the anxiolytic activity. Maximal electroshock induced convulsion (MES) (Phenytoin-20mg/kg i.p as a standard drug) and Pentylenetetrazol (PTZ) induced seizures analyzed where Diazepam (5mg/kg) i.p as a standard drug to assess the anticonvulsant activity. Substantial changes in all tested activities EPM, OFT in anxiety model and MES, PTZ in anticonvulsant model were observed. The results revealed that ethanol leaf extract (400 mg/kg p.o.) was more impetus due to the high amount of flavonoid, phenolic compounds, steroids, terpenoid contents possess tremendous anti-anxiety whereas the ethanol root extract (400 mg/kg p.o.) and ethanol leaf extract (400 mg/kg p.o.) produce significant anticonvulsant potential effect compared to the control and standard drug treatment group. This study suggested that the plant M. jalapa is a much more active compound consistent medicinal plant to derive a potent drug against anxiety and convulsion.
Role of Stress Situation at Diabetic Nephropathy Development
Authors:   AL–Esraa University College , Baghdad , Iraq., Al-Dahy Dr.Lara Balasim
Published: September 2021

Background: Diabetic Nephropathy (DN) is disorder occur in renal nephrons caused by diabetes mellitus (DM) disease . Therefore uncontrol DM consider as high risk factor for developed renal disease , the un-control DM detection by high glycated hemoglobin (HbA1c) level for long periods . Cystatin C is monomeric and non-glycosylated protein many roles in human body such as diagnosis role in renal, heart and neurology diseases . Cortisol is the most important stress hormone ,it’s release from adrenal cortex layer to all cells by blood .The functions of cortisol in cells include: regulation of blood sugar levels, metabolic process , anti-inflammatory, and other functions. Objective of the Study: Explain effect of stress situation on Diabetic Nephropathy disease Materials and Methods: The present study included 40 DM cases group classified into 20 control DM (without DN) and 20 un-control DM (with DN) ,all subjects age in current study was more than 50 years of both genders. The current study focused on psychological situation of all study individuals when sample collection ,and the blood sample usedto measured cortisol ,HbA1c and cystatin c levels Results: This study shows elevation of serum Cystatin C level , serum cortisol level and HbA1c in un-control DM (with DN) group compare with control DM (without DN) group Conclusion: This study confirms that depression can cause elevation of cortiaol level that lead to increase HbA1c level to result un-control DM , that cause early stage of DN . DN detect by elevation of cystatin C level
KẾT QUẢ ĐIỀU TRỊ CHẤN THƯƠNG SỌ NÃO VỠ XƯƠNG SỌ TẠI BỆNH VIỆN ĐA KHOA TỈNH THÁI BÌNH
Authors: Minh Hải Vũ
Published: September 2021

Mục tiêu: Nhận xét tỉ lệ, triệu chứng lâm sàng, hình ảnh chụp cắt lớp vi tính và kết quả điều trị 68 bệnh nhân chấn thương sọ não vỡ xương sọ. Phương pháp: Mô tả cắt ngang 68 bệnh nhân chấn thương sọ não vỡ xương sọ điều trị tại Khoa Phẫu thuật thần kinh–Cột sống bệnh viện Đa khoa tỉnh Thái Bình trong khoảng thời gian từ tháng 2 đến tháng 9 năm 2020. Kết quả: 68 bệnh nhân vỡ xương sọ do chấn thương trong tổng số 534 bệnh nhân chấn thương sọ não trong khoảng thời gian 8 tháng, chiếm tỉ lệ (12,7%) gồm 56 nam (82,4%); 12 nữ (17,6%); Tuổi nhỏ nhất: 3; Tuổi cao nhất: 96; Tuổi trung bình: 33,26 ± 22,15 tuổi. Nguyên nhân do tai nạn giao thông (63,2%); tai nạn sinh hoạt (29,5%); tai nạn lao động (4,4%); bao lực chiếm (2,9%). Triệu chứng lâm sàng đau đầu chiếm (88,2%); nôn (29,4%); vết thương vùng đầu (33,8%); sưng nề, tụ máu dưới da đầu (27,9%); bầm tím quanh mắt (20,6%). Đa số bệnh nhân mức độ nhẹ (GCS: 14-15 điểm: 91,2%). Chụp cắt lớp vi tính thấy: Vỡ vòm sọ chiếm (79,4%), vỡ nền sọ (20,6%); máu tụ ngoài màng cứng chiếm (39,7%), máu tụ dưới màng cứng cấp tính (33,8%), chảy máu màng mềm (27,9%). Đa số điều trị nội khoa chiếm (88,2%), chỉ có (11,8%) phẫu thuật. Đa số bệnh nhân có kết quả tốt (97,1%). Kết luận: Chấn thương sọ não vỡ xương sọ chiếm tỉ lệ (12,7%), thường gặp ở nam giới, nguyên nhân chủ yếu do tai nạn giao thông.
ĐÁNH GIÁ KẾT QUẢ PHẪU THUẬT ĐIỀU TRỊ UNG THƯ ĐẠI TRÀNG SIGMA
Authors: Lê Huy Trịnh , Tiến Đạt Mai
Published: September 2021

Mục tiêu nghiên cứu: Đánh giá kết quả phẫu thuật điều trị ung thư đại tràng sigma tại bệnh viện K từ 10/2015 đến tháng 7/2016. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, hồi cứu kết hợp tiến cứu trên55 bệnh nhân ung thư đại tràng sigma được phẫu thuật tại bệnh viện K từ 10/2015-7/2016. Kết quả: Phẫu thuật mở chiếm 81.8%, nội soi chiếm 18.2%. Thời gian phẫu thuật trung bình chung là 128 phút, giữa mổ nội soi và mổ mở không có sự khác biệt. Số lượng máu mất trung bình là 115ml, mổ nội soi mất ít máu hơn mổ mở. Thời gian có trung tiện trở lại trung bình 3.26 ngày, của mổ nội soi có thời gian ngắn hơn so với của mổ mở. Thời gian hậu phẫu trung bình là 10.28 ngày, mổ nội soi có thời gian ngắn hơn so với mổ mở. Mổ nội soi và mổ mở không có khác biệt về số lượng hạch trung bình vét được và tỷ lệ vét được từ 12 hạch trở lên. Kết luận: Phẫu thuật nội soi cho thấy hiệu quả phẫu thuật cũng như độ an toàn tương đương mổ mở trong khi cải thiện chất lượng cuộc sống và giảm nguy cơ một số biến chứng sau mổ nên cần được áp dụng rộng rãi cho bệnh nhân ung thư đại tràngsigma.