bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 3 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Authors: Fandrei David , Seiffert Sabine , Rade Michael , Rieprecht Susanne , Gagelmann Nico , Born Patrick , Wiemers Thomas , Weidner Heike , Kreuz Markus , Schassberger Tamara , Koßmann Jannik , Mangold Marlene , Fürst Daniel , Fischer Luise , Baber Ronny , Heyn Simone , Wang Song Yau , Bach Enrica , Hoffmann Sandra , Metzeler Klaus H. , Herling Marco , Jentzsch Madlen , Franke Georg-Nikolaus , Köhl Ulrike , Friedrich Maik , Boldt Andreas , Reiche Kristin , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian
Published: January 2025

Detailed overview of all regimens administered as bridging therapy for each patient.
Supplementary Table 1 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Authors: Fandrei David , Seiffert Sabine , Rade Michael , Rieprecht Susanne , Gagelmann Nico , Born Patrick , Wiemers Thomas , Weidner Heike , Kreuz Markus , Schassberger Tamara , Koßmann Jannik , Mangold Marlene , Fürst Daniel , Fischer Luise , Baber Ronny , Heyn Simone , Wang Song Yau , Bach Enrica , Hoffmann Sandra , Metzeler Klaus H. , Herling Marco , Jentzsch Madlen , Franke Georg-Nikolaus , Köhl Ulrike , Friedrich Maik , Boldt Andreas , Reiche Kristin , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian
Published: January 2025

Overview of bridging therapies and clinical characteristics.
Supplementary Figures S15-S19 from Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Authors: Fandrei David , Seiffert Sabine , Rade Michael , Rieprecht Susanne , Gagelmann Nico , Born Patrick , Wiemers Thomas , Weidner Heike , Kreuz Markus , Schassberger Tamara , Koßmann Jannik , Mangold Marlene , Fürst Daniel , Fischer Luise , Baber Ronny , Heyn Simone , Wang Song Yau , Bach Enrica , Hoffmann Sandra , Metzeler Klaus H. , Herling Marco , Jentzsch Madlen , Franke Georg-Nikolaus , Köhl Ulrike , Friedrich Maik , Boldt Andreas , Reiche Kristin , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian
Published: January 2025

Fig. S15: Gating scheme used for quantification of CAR-T cells. Fig. S16: Gating scheme used for immune checkpoint marker detection on non-transduced and CAR-T cells. Fig. S17: Gating scheme used for T cell subsets. Fig. S18: Gating scheme used for detection of perforin and granzyme B on non-transduced and CAR-T cells. Fig. S19: Gating scheme used for flow cytometry readout of the in vitro cytotoxicity assay.
The overlap between type 1 diabetes and celiac disease in children and the role of tTG-IgA positivity in endoscopy decision
Authors: Eviz Elif , Sari Sinan , Uslu Kizilkan Nuray , Doger Esra , Yesiltepe Mutlu Gul , Eğritaş Ödül , Arikan Cigdem , Bideci Aysun , Dalgic Buket , Hatun Sukru
Published: January 2025

Introduction: Celiac Disease (CD)-related antibody positivity in children with Type 1 Diabetes (T1D) may fluctuate and become negative spontaneously. There are uncertainties about the optimal tTG-IgA titre and timing of endoscopy in the diagnosis of CD, and this study aimed to contribute to the debate on the tTGA-IgA threshold titre for endoscopy decisions in children with T1D.
Methods: The data of 991 children with T1D who had undergone serologic evaluation for CD were analysed retrospectively. The tTG-IgA positivity rate and the upper limit of normal (ULN) tTG-IgA positivity were assessed. Participants were grouped according to the frequency, course and test results of tTG-IgA tests. Those with and without histopathologic diagnosis of CD by endoscopic biopsy were compared in terms of tTG-IgA screening time and tTG-IgA predictive values.
Results: In 10.2% (n:101) of all cases, tTG-IgA antibody was positive and endoscopic biopsy was performed in 68.3% (n:69) of these cases. Of all cases, 4.3% (n:43) were diagnosed with CD by endoscopic biopsy. A tTG-IgA titre of 7xULN and above was found to be the best predictive value for the diagnosis of CD with 79.1% sensitivity, 80.8% specificity 87.2% positive predictive value and 70% negative predictive value.
Conclusions: Approximately 10% of antibody positive cases showed fluctuating and low titre positivity, and no CD was detected by endoscopic biopsy in the group with fluctuating antibody course. The results of our study suggest that endoscopy in children with tTG-IgA levels 7xULN or above may prevent both false positive results and missed cases.
Disseminated Marginal Zone Lymphoma in a Patient with Lyme Neuroborreliosis: A Case Report
Authors: Weisbjerg Dorit Kraft , Skarphedinsson Sigurdur , Andersen Nanna Skaarup , Kristensen Louise , Larsen Thomas Stauffer , Knudtzen Fredrikke Christie
Published: January 2025

Introduction: Lyme borreliosis has been associated with lymphoma, particularly cutaneous lymphomas. The literature is conflicted regarding the effect of antibiotic therapy in cutaneous marginal zone lymphomas (MZLs) in individuals with Lyme borreliosis. We present a patient diagnosed with Lyme neuroborreliosis (LNB) and disseminated MZL. Case Presentation: A 67-year-old man was seen due to 6 weeks of neuropathic pain with nightly worsening, headache, and 5 kg weight loss. Two weeks prior to symptom debut, he had a tick bite in the left groin, no subsequent rash. A lumbar puncture revealed mononuclear pleocytosis and elevated CSF protein. The patient was admitted and started on ceftriaxone. The Borrelia burgdorferi intrathecal test showed intrathecally produced Borrelia antibodies, and treatment was changed to doxycycline with a total treatment duration of 21 days. A PET/CT revealed enlarged lymph nodes with increased FDG uptake. On pathological examination, the CSF showed 62% clonal B cells – compatible with low-grade B-cell lymphoma. Examination of bone marrow and an inguinal lymph node confirmed disseminated MZL. A control lumbar puncture 8 weeks later showed declining pleocytosis and clonal B cells. At last follow-up 20 months later, he was still asymptomatic and had not required antineoplastic treatment. Conclusion: To our knowledge, this is the first published case of LNB with non-cutaneous B-cell lymphoma treated and remitting on antibiotics alone. Antibiotic treatment for Borrelia-positive lymphomas has yet to be investigated with high-evidence study designs, so clinicians are encouraged to publish both positive and negative findings relevant to this. We believe this case brings new perspectives to future diagnosis and treatment of lymphomas in patients with verified Lyme borreliosis.
Pokémon e as fronteiras da identidade nas diferentes plataformas midiáticas
Authors: Carmo João Paulo de Oliveira , Carneiro Maristela , Bragagnolo Bibiana
Published: January 2025

Pokémon is a Japanese media franchise that comprehends a vast array of products, being characterized for its transmedia inclination. The narratives that permeate the franchise revolve around fictional creatures distinctive for their designs and patterns of behavior, named pokémon. In this investigation, we aim to observe how identities are formulated in the dialogue between the graphic aspects used in the construction of characters in Pokémon and matters of gender, performance and sexualities. To this end, we will analyze diferente Pokémon Productions responsible for materializing narratives that, due to their imagery and plot dynamics, reflect on the representations and performances of their characters in relation to genders and sexualities.
Mercurial Queer: Localized Sexualities in Contemporary Moroccan Cinema
Authors: Reeser Todd W.
Published: January 2025

Queer Moroccan cinematic subjects tend to leave the Maghreb for the West to fully realize their “gay” sexual subjectivity. By contrast, two recent Moroccan films, Maryam Touzani’s The Blue Caftan (Le Bleu du caftan, 2022) and Nabil Ayouch’s Razzia (2017), insert queerness into localized forms or, more precisely, into localized networks, defined through time and space and in dialogue with Indigenous representational forms. Queer is not suddenly visible or “out,” but rather is shown to have always been present locally, meaning that Western discursive taxonomies are not needed. These two films opens up possibilities for queer Moroccan film to ignore and speak back to Western hegemonic constructs of sexuality.
Monitoring Soil Water Content and Measurement Depth of Cosmic-Ray Neutron Sensing in the Tibetan Plateau
Authors: Wang Xin , Liu Rong , Köhli M. , Marach J. , Wang Zuoliang
Published: January 2025

This work aims at evaluating the potential application of two cosmic-ray neutron sensing (CRNS) soil water content (SWC) retrieval methods and discusses the effective measurement depth of CRNS retrieval and vertical weights of different layers in a semihumid alpine meadow on the Tibetan Plateau. In this study, the widely used N0 method and the latest published method derived from physical principles named the universal transport solution (UTS) were used for SWC estimation during the whole nonfrozen season on the Tibetan Plateau. The N0 and UTS methods successfully retrieved the SWC on the Tibetan Plateau, and their variations were generally consistent. The effective measurement depths calculated by the N0 and UTS methods showed similar fluctuation patterns, ranging from 9.7 to 14.5 cm and 17.8 to 20 cm, with mean values of 12.0 and 19.2 cm, respectively. This work verified that the weighting methods of the N0 and UTS models provided credible performance for the effective measurement depths. The N0 method provided measurement depths more close to the surface, and the UTS method yielded slightly deeper averages. The UTS equation had a more sensitive response to periods of low precipitation. Including detailed Ultra Rapid Neutron-Only Simulation (URANOS) Monte Carlo simulations of the full time series, we find specifically an excellent agreement in the summer period. Our analysis suggests that CRNS is a promising innovation for SWC measurement and can be extended in its application at hectometer scales to monitor SWC in the Tibetan meadow ecosystem.

Significance Statement

The purpose of this study is to better understand if cosmic-ray neutron sensing (CRNS) has the potential to sense soil water content (SWC) for the Tibetan meadow ecosystem with harsh climate conditions. Techniques for measuring SWC have evolved over many decades, from point-scale measurements of a few meters to satellite-based remote sensing methods of several kilometers, each with advantages and disadvantages. This is important because CRNS has emerged to fill the scale gap between point measurements and microwave remote sensing methods. The results are helpful in assessing the applicability of CRNS in alpine meadow ecosystems on the Tibetan Plateau.
Convection-Permitting Ensembles of an Isolated Mountain Thunderstorm during RELAMPAGO/CACTI
Authors: Lopez Andres , Kirshbaum Daniel J. , Lareau Neil
Published: January 2025

The north–south-oriented Sierras de Córdoba (SDC) ridge in central Argentina is noted for initiating thunderstorms that may grow into intense mesoscale convective systems (MCSs). It also initiates more isolated, shorter-lived cells under weaker synoptic forcing. These cells are less impactful than MCSs but may be difficult to predict in convective-scale numerical weather prediction (NWP) due to their strong sensitivities to subgrid and partially resolved processes. To study the mechanisms and predictability of such cells, convection-permitting ensemble simulations were conducted of an isolated, diurnally forced SDC thunderstorm during Cloud, Aerosol, and Complex Terrain Interactions (CACTI)/Remote Sensing of Electrification, Lightning, and Mesoscale/Microscale Processes with Adaptive Ground Observations (RELAMPAGO). The rich observational data facilitated detailed ensemble verification, where dry biases in the surface energy balance and soil moisture were identified. These biases promoted rapid removal of convective inhibition and an early onset of precipitating cells over the SDC that were shallower and weaker than the observed cell. Correction, and then overcorrection, of the soil moisture bias in two successive ensembles was required to rectify the surface energy balance and improve the representation of the SDC cell. Nevertheless, substantial ensemble variability in convective precipitation was found, with some members producing more widespread convection than observed and others producing no deep convection at all. This variability was largely explained by a combination of thermodynamic and dynamic mechanisms, dominated by a positive sensitivity of convective precipitation to preconvective moist instability over the ridge. Secondary sensitivities were found to low-level upward mass flux and midlevel cross-barrier winds, the latter of which caused gravity waves with elevated downdrafts that tended to suppress incipient clouds.
The Influence of Psychosocial Skills on the Development of Musical Abilities: Cross-Sectional Results From Secondary School Pupils in Latvia
Authors: Voitova Tatjana , Bernhofs Valdis , Müllensiefen Daniel
Published: January 2025

Psychosocial skills are variables related to human behavior, beliefs, and attitudes and shape social interactions, learning processes, academic achievements, and general goal-directed behavior. Psychosocial skills seem particularly important during the adolescent period when large changes in goal setting, learning attitudes, and ability development take place. However, it remains unclear to what degree the growth of musical abilities is influenced by psychosocial skills in musically gifted children and children who are not musically gifted. Hence, the aim of this study is to determine the impact of psychosocial skills on music listening abilities beyond demographics, musical training, and cognitive factors. At four secondary schools in Latvia (two general schools and two schools for musically gifted individuals), we tested 191 adolescents (aged 11–18 years) with an online test battery assessing musical listening abilities, cognitive ability, socio-demographics, musical training activities, and a range of psychosocial skills. Data were analyzed through a series of hierarchical regression models determining the effect of different groups of independent variables. Results indicate that, in general, psychosocial variables make a substantial contribution to musical listening abilities beyond demographics, musical training, and cognitive capacity. When students from general secondary schools and schools for the musically gifted were analyzed separately, the contribution of psychosocial skills differed noticeably, with a greater relative importance for musically gifted children. Thus, the results suggest an important role of psychosocial variables in musical giftedness education. However, the specific role of individual psychosocial variables such as grit still needs to be clarified in future studies.
Multimodal identity work: The power of visual images for identity construction in the gig economy
Authors: Alacovska Ana , Bucher Eliane , Fieseler Christian
Published: January 2025

We adopt a visual methods approach, in conjunction with an interview-based study, to investigate the identity work of creative workers who sell their services remotely as online freelancers via gig economy platforms. Based on visual self-portrayals elicited from 53 remote gig workers, including illustrators, animators and graphic designers, and their subsequent verbal reflections on these images, our study elucidates the generative power of visual images for gaining insights into identity work, especially in non-traditional work contexts facilitated by digital technologies. We distinguish key identity work strategies that remote gig workers use to construct their identities in relation to idealized, publicly available and free-floating imaginaries of platform labour. These strategies ranged from fully embracing such imaginaries to their vehement rejection, as well as strategies aimed at maintaining a balance between these extremes. Besides the embodied, sensorial intensities and imaginative projections underpinning such identity construction in the gig economy, our analysis foregrounds also the spatial aspects of identity work. Theoretically, we propose a redefinition of identity work as a multimodal accomplishment rather than exclusively a narrative one to better explain the elusive and contradictory aspects of identity work, including its affective and spatial character.
Stabilisation Policy Options in a ‘Lower and Longer’ Interest Rates Environment
Authors: Nachane D. M.
Published: January 2025

During episodes of severe depression, interest rates can approach the zero lower bound (ZLB) and stay there for a fairly long time. Mainstream macroeconomic theory (the so-called New Consensus Economics) then fails to provide adequate guidance under a Taylor type rule to conventional monetary policy. Various alternatives have been suggested to revitalise monetary policy in such a situation. The major alternatives can be divided into three categories, namely, (a) those that do not recognise the ZLB as an effective floor, (b) those based on the Keynesian liquidity trap and (c) those based (implicitly) on Hawtrey’s credit deadlock. We discuss these alternatives with a special focus on quantitative easing (QE). In particular, we draw attention to the largely ignored fact that QE had been suggested by the British economist Hawtrey at least as early as 1931 in the policy debates on ways to emerge from the Great Depression.

JEL Codes: E4, E5, N1
Fascists and Gentlemen? The Last Dictatorship's Vexed Relationship with Argentinian Fascism (‘Nacionalismo’)
Authors: Kressel Daniel Gunnar
Published: January 2025

While there is a consensus among historians that Argentina's Last Dictatorship was one of the most radically right-wing regimes in modern Latin American history, the question of whether this regime's ideology was informed by fascist ideology has remained, to a large extent, open. This article explores the relationship between the Proceso de Reorganización Nacional (PRN) and Argentina's fascist movement, self-labeled the ‘nacionalistas’. It begins by examining how, in the 1970s, this movement's ‘revolutionary’ sectors resurged in demand for a constitution of a totalitarian and corporatist regime in Argentina. The study then illuminates which components of the nacionalista doctrine the PRN chose to incorporate into its public discourse, particularly in its early and more ideologically foundational years. Finally, the article explores the strained relationship between the PRN and nacionalistas amid the regime's neoliberal reforms. The article's findings suggest that, despite its murderousness, the PRN was of the least indebted to neo-fascist ideology of the military regimes that had ruled Argentina since 1943.
Sacred song, spirituality and social justice
Authors: Arnold Jonathan
Published: January 2025

This article explores the relationship between music, particularly sacred singing, spirituality and social justice, by means of investigating, through a combination of scholarship, case studies and first-hand experience, how music and singing are able to encourage community cohesion, promote human dignity, and be an embodied form of spirituality; how music and song can challenge societal assumptions and norms, as well as confront injustice and inhumanity; and also how music and song can express the pain of human suffering and political oppression and challenge them, focusing on the particular example of the singing revolution in the Baltic states and the work of Arvo Pärt.
Resonant relationships and ecological crisis
Authors: Porter Mark
Published: January 2025

As a means of world relation and interaction, music can be a powerful medium for situating human beings in relation to other entities and spaces by which they are surrounded. While Christian musical practices often focus most strongly on human–divine relationships, a recent turn to concepts of resonance suggests the potential to consider a wider range of interactions and aspirations. I propose that attentiveness to dimensions of resonance might prove productive in connection with contemporary experiences of ecological crisis and I suggest that rethinking our patterns of resonant interaction may be an important part of our response to these challenges.
A qualitative investigation of how UK-based educational psychologists use a cognitive behavioral therapy workbook with young people
Authors: Redburn James , Hayes Ben
Published: January 2025

The “workbook” is an underexplored concept in the literature of cognitive behavioral therapy (CBT). Unlike manuals, workbooks provide resources without prescribing standardized procedures for practitioners to follow, potentially allowing for greater flexibility. This study explored the experiences of six UK-based educational psychologists using a popular workbook, Think Good – Feel Good (TGFG), to support CBT for young people (YP). Semistructured interviews were conducted online, and data were analyzed using thematic analysis. Five themes were identified. Practitioners felt practically and emotionally supported by TGFG. Think Good – Feel Good was used flexibly, combined with other therapeutic modalities, and its resources were adapted. Think Good – Feel Good helped practitioners make CBT developmentally appropriate and engaging for YP. There were potential benefits and challenges to school staff using TGFG in tandem with psychologists. Finally, supplementary resources (e.g., worksheets) helped to contain the emotional intensity of therapeutic interactions and supported practitioners to develop therapeutic alliances with YP.
‘The national media just sees Muslims as if they are not people like us’: The alternate social imaginaries of local journalists reporting on Muslims
Authors: Haq Nadia
Published: January 2025

This article contributes a missing insight into the everyday experiences of local journalists when reporting on stories involving Muslims. Using qualitative interviews with local and national journalists on their experiences of reporting stories involving Muslims, I investigate how ideas of belonging shape their journalistic practices. The study finds that the experiences of national journalists mirror the Othering of Muslims found in studies of press discourse, reflecting national newspapers’ preoccupation with questions relating to the loyalty and belonging of British Muslims. In contrast, the experiences of local journalists’ and their very different interpretations of journalism built on ideas of community, audience and public interest reflect conscious efforts towards fairer reporting on stories involving Muslims. Using Charles Taylor’s concept of social imaginaries to make sense of these findings, I demonstrate how the accounts of the local journalists reflected a social imaginary of their audiences that very much included, rather than excluded, local Muslim communities. This inclusive social imaginary became reflective of the practices of local newspapers, both in terms of their media outputs and their own journalistic identity.
Performance Evaluation of University-Based Scientific Research Institutions With a Non-Independent Parallel System
Authors: Guo Junming , Liu Chuanbin , Zhang Han , Wang Dan , Lu Jintao
Published: January 2025

Performance management in university-based scientific research institutions is essential for driving reform, advancing education quality, and fostering innovation. However, current performance evaluation models often focus solely on research indicators, neglecting the critical interdependence between the education and research systems. This oversight leads to inefficiencies in resource allocation and an underestimation of overall institutional performance, particularly in universities with varying development levels. To address these deficiencies, this study introduces two innovative two-stage data envelopment analysis models: the group-frontier and meta-frontier evaluation models. The findings are validated using data from 144 universities across China. They demonstrate that the proposed models effectively mitigate the underestimation of efficiency in traditional models and accurately reflect the intertwined nature of university subsystems and the disparities in university development. These results offer valuable insights for improving the performance of scientific research institutions and informing the strategic decisions of university administrators and government education departments.
Hierarchy and authority: ideological motivations of opponents of the affirmation of the rights of Latin American immigrants in Chile / Jerarquía y autoridad: motivaciones ideológicas de la oposición hacia la afirmación de derechos de inmigrantes latinoamericanos en Chile
Authors: Obregón Felipe , Bahamondes Joaquín , González Lya , Gutiérrez Francisca , Cárdenas Manuel
Published: January 2025

Prejudice and anti-immigrant attitudes are strongly motivated by more general ideological attitudes. Considering the current situation of migration in Chile, we conducted two studies on the ideologies underlying rejection of the affirmation of the rights of the Latin American migrant population in Chile. The first study ( n = 1,103) examined the associations between right-wing authoritarianism (RWA) and social dominance orientation (SDO) on the one hand and opposition to the affirmation of rights on the other. Subsequently, Study 2 ( n = 1,046) analysed the moderating role of perceptions of criminal threat in the relationship between RWA and opposition to the affirmation of rights. The results show that there is a distinct effect of both variables on the dependent variable, and that the relationship between RWA and the affirmation of immigrants’ rights in Chile is conditioned upon the perception of criminal threat.
Teacher experiences with twice-exceptional students
Authors: Sakar Seda , Baloglu Mustafa
Published: January 2025

We investigated the observations and experiences of k-12 teachers and school counselors with twice-exceptional students. For this purpose, we used the phenomenological research design. The study group consisted of nine teachers and two counselors who had working experiences with twice-exceptional students. We prepared and used an interview form to collect the data via interviews held with teachers and counselors. Additionally, we conducted a focus-group interview with three teachers. Results show various prominent characteristics of 2e students from the views of teachers and counselors such as creativity, solid verbal skills in areas of interest, inconsistent academic performances, and restlessness. Participating teachers and counselors expressed the need for professional development and collaboration when working with twice-exceptional students. Several recommendations were made, specifically for teachers and counselors.
The Cumulative Model for Empirical Research in the Arts: A Semiotic Answer to the Challenge of Interdisciplinarity
Authors: Gallegos González Héctor G. , van Heusden Barend
Published: January 2025

The empirical study of the arts would greatly benefit from truly interdisciplinary research. The diverse epistemic perspectives of the main disciplines concerned with researching the artistic experience (humanities, psychology, natural sciences) pose, however, a challenge to their collaboration. Rather than starting from a conceptual definition of art, we take a theoretical, cognitive-semiotic stance, analyzing art as a recursive imaginative sense-making process. This provides us with a clear picture of the multilayered structure of the artistic. As it acknowledges the innate, the learned, and the semiotic dimensions that together are constitutive of the artistic experience, the Cumulative Model for Empirical Research in the Arts, although it does not offer a practical experimental guide, provides a comprehensive theory-based framework that can support cooperation across disciplines in the research of the arts.
The effect of early rehabilitation on therapeutic outcomes in ICU patients on mechanical ventilation: A meta-analysis
Authors: Li Saisai , Xu Xiulu , Hu Jingjing , Wang Yuexia
Published: January 2025

Objective:

To evaluate the effect of early rehabilitation on therapeutic outcomes of patients in the ICU requiring mechanical ventilation.

Methods:

Electronic databases up to June 15, 2024 were searched. Randomized controlled trials (RCTs) that compared early rehabilitation with standard rehabilitation for patients in the ICU on mechanical ventilation were included. The effects of early rehabilitation on outcomes such as duration of mechanical ventilation (days), ICU length of stay (days), hospital length of stay (days), ICU and in-hospital mortality, and ICU-acquired weakness (ICU-AW) were evaluated using a random-effects model.

Results:

Nineteen RCTs met the inclusion criteria for this study, involving 3076 patients in the ICU on mechanical ventilation. Meta-analysis based on the random-effects model showed that early rehabilitation significantly reduced the duration of mechanical ventilation, ICU-AW risk, ICU length of stay, and total hospital length of stay. Analysis of the timing of early rehabilitation indicated that implementing early rehabilitation within ⩽48 or ⩽72 h after ICU admission or mechanical ventilation had varying effects on the duration of mechanical ventilation, ICU length of stay, and total hospital length of stay.

Conclusion:

Early rehabilitation can improve the therapeutic outcomes for ICU patients on mechanical ventilation. The optimal time for implementing early rehabilitation appears to be 48–72 h after ICU admission or initiation of mechanical ventilation, but further research is needed.

Clinical trial number:

INPLASY202470068.
Taking consent for granted: A case for rethinking hegemony
Authors: Osman Sonny
Published: January 2025

This paper focuses on the position of consent in prevailing models of hegemony. It is argued that the commonly invoked consent assumption is a weakness in the hegemony construct that demands review. Consent is purportedly a crucial element of the hegemony dynamic, yet is often overlooked in favour of dominance and resistance. To illustrate this, the paper provides a genealogical account of the consent premise as it is formulated in notable models of political hegemony. This reveals a declining interest in the purportedly crucial consent element of the hegemony construct, accompanied by a reductive view of language and discourse. Next, the paper contrasts the collective consent premise with modern notions of individual sexual consent. This highlights the connection between the consent assumption and hegemonic masculinity. It is observed that if hegemony is based on modes of control and the lack of meaningful choice, it is not founded on consensus. Rather, it is postulated that such conditions might aptly be described as a form of tolerance. This concept is outlined here as a means of departure towards theorizing how hegemonic domination might be actualized discursively without the requirement of consent. In this respect, the paper responds to proponents of post-hegemony by arguing that it is not the concept of hegemony that is outmoded, but rather how it is secured.
The fear of uselessness: From the normalization to the enjoyment of ecological destructiveness
Authors: Schaupp Simon
Published: January 2025

Protest against the mitigation of climate change has become a core issue for right-wing populism across the globe. Such politics can mobilize a widespread normalization of ecological destructiveness. Drawing on Frankfurt School critical theory and Lacanian psychoanalysis, this article argues that climate protection provokes such outrage because it appears to negate all the sacrifices that had to be made for the world of work. Thus, the normalization of destructiveness relates to a fear of uselessness common to the modern subject. This fear is taken up by the right-wing anti-climate protest and turned into something positive to be enjoyed. The phenomenon is illustrated by interviews with Swiss construction workers about their experiences with climate change.
‘For the good of the Gugu Badhun people’: Indigenous Nation building, economic development and sharing as sovereignty
Authors: Gertz Janine , Petray Theresa , Jorgensen Miriam , Vivian Alison , Achterberg Coralie
Published: January 2025

As part of an ongoing process of Indigenous Nation Building, Gugu Badhun Nation is engaged in developing an economy according to Gugu Badhun values. Rather than simply mimicking capitalism, the practice of visioning this economy begins with considering core cultural principles for the Nation. Sharing is central for Gugu Badhun, and we argue that sharing is considered an act of sovereignty stemming from Gugu Badhun law. Other factors emerge from the focus on sharing, such as the responsibility to look after one another, Country, plants and animals, and neighbouring Nations. This articulation of sharing as sovereignty illustrates Indigenous conceptions of sovereignty as a verb, rather than a noun. Storytelling is one way that Gugu Badhun enacts economic sovereignty through centring the Nation. Our research demonstrates the transformative potential of Indigenous Nation Building and Gugu Badhun people’s freedom to consider and express a preference for alternative economies.
A phenomenological approach to Ibn Khaldun's concept of group feeling
Authors: Augusto Alexandre Henrique
Published: January 2025

Ibn Khaldun's groundbreaking sociological investigations led to the development of the concept of group feeling ( asabiyyah), responsible for describing not only the basis of all social cohesion, but also to explain the cyclical rise and fall of communities in a philosophical theory of history. We will analyze Malešević's naturalistic anthropological interpretation of the nature of group feeling and complement it with a phenomenological interpretation of the subjective experience of asabiyyah. We will rely on Stein's insights into the problem of empathy and Schütz's phenomenological investigations into the structure of social relationships. We expose Ibn Khaldun's concept of asabiyyah, followed by Malešević's analysis of the concept. Afterwards, we analyze how Malešević uses group feeling to explain the formation of group solidarity in nationcentric States. After showing how phenomenology can answer the open-ended questions posed by Malešević in his article, we lean on Stein’s and Schütz's investigations in order to describe asabiyyah phenomenologically.
Rethinking revolution in the Andes: Contrasting logics of social transformation in Bolivia
Authors: Augsburger Aaron
Published: January 2025

Indigenous movements throughout the Andes have put forward the idea of plurinationalism as a theoretical concept of social transformation. Plurinationalism demands a complete overturning of the existing state structure and a rethinking of the idea of the national collective and social formation undergirding a given nation state. In essence, plurinationalism, through a variety of both ideological and material programs and processes, recognizes and incorporates the various distinct indigenous nationalities that comprise a social formation into a unified state apparatus while maintaining and expanding those communities’ powers of autonomy, self-governance, and cultural and economic reproduction. Plurinationality, therefore, can be understood to represent the most fundamental and critical endeavor put forward by Bolivia's largely indigenous popular classes over the past two decades. Not only does the concept challenge our understanding of the modern socio-political formations of the nation state, but it also offers a distinct perspective on the notion of revolution.
Feeding- and Light-Cycle Synergistically Regulate Mouse Blood Pressure Daily Rhythm via Bmal1-Dependent and Independent Mechanisms
Authors: Hou Tianfei , Su Wen , Chacon Aaron N. , Lin An-Hsuan , Guo Zhenheng , Gong Ming C.
Published: January 2025

Cardiovascular health requires the orchestration of the daily rhythm of blood pressure (BP), which responds to changes in light exposure and dietary patterns. Whether rhythmic light and feeding can modulate daily BP rhythm directly or via modulating intrinsic core clock gene Bmal1 is unknown. Using inducible global Bmal1 knockout mice (iBmal1KO), we explored the impact of rhythmic light, rhythmic feeding, or their combination on various physiological parameters. Daily rhythms of BP, heart rate, and locomotor activity were monitored via radiotelemetry, while food intake patterns were tracked using the BioDAQ system. Respiratory exchange ratio (RER) and energy expenditure (EE) were assessed through indirect calorimetry. In addition, spectrum analysis was employed to analyze spontaneous baroreflex sensitivity and heart rate variability, and urinary norepinephrine excretion was quantified using high-performance liquid chromatography (HPLC). Neither rhythmic feeding nor rhythmic light alone was sufficient to reinstate the daily BP rhythm in arrhythmic iBmal1KO mice. However, combining the light and feeding cues in synchrony partially restored the daily BP rhythm. Interestingly, rhythmic feeding alone robustly reinstated RER and EE rhythms, even without rhythmic light. Similar to BP, the partial reinstatement of the daily rhythms in heart rate and locomotor activity was observed only when rhythmic light and feeding were applied in tandem. Rhythmic light by itself did not restore the light–dark phase difference in baroreflex sensitivity, urinary norepinephrine excretion, or the daily rhythm of heart rate variability. However, rhythmic feeding, alone or in combination with rhythmic light, successfully reinstated the light–dark phase differences in these parameters. In the absence of Bmal1, the synergy between rhythmic light and feeding can partially restore daily BP rhythm.
Gingival keratinocyte adhesion on atomic layer-deposited hydroxyapatite coated titanium
Authors: Abushahba Faleh , Riivari Sini , Areid Nagat , Närvä Elisa , Kylmäoja Elina , Ritala Mikko , Tuukkanen Juha , Vallittu Pekka K. , Närhi Timo O.
Published: January 2025

This study aimed to evaluate the effects of the atomic layer deposited hydroxyapatite (ALD-HA) coating of the titanium (Ti) surface on human gingival keratinocyte (HGK) cell adhesion, spreading, viability, and hemidesmosome (HD) formation. Grade 2 square-shaped Ti substrates were used ( n = 62). Half of the substrates were ALD-HA coated, while the other half were used as non-coated controls (NC). The ALD-HA surface was characterized with scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) analysis. The initial cell adhesion and HD formation of HGKs were evaluated after a 24-h cultivation period. The cell proliferation was assessed by cultivating cells for 1, 3, and 7 d. The expression levels of the integrin mediating cell adhesion were detected with the Western Blot method. In addition, cell spreading and expression of the proteins mediating cell adhesion were imaged using a confocal microscope. SEM-EDS analysis demonstrated the formation of HA on the ALD-HA surfaces. The relative cell attachment was significantly higher ( p < .05) on the ALD-HA compared to the NC surface after 1 and 3 d of cell culture. No significant difference was found in integrin α6 or β4 expression. The microscope evaluation showed significantly increased cell spreading with peripheral HD expression on ALD-HA compared to the NC surfaces ( p = .0001). Moreover, laminin γ2 expression was significantly higher on the ALD-HA than on the NC surfaces ( p < .001). Compared to the NC Ti surface, the ALD-HA coating has favorable effects on HGK proliferation, growth, and cell spreading. This indicates that the ALD-HA coating has good potential for improving mucosal attachment on implant surfaces.
Historical Housing Discrimination, Redlining, and the Contemporary Distribution of Local Economic Development Funding: The Case of Chicago
Authors: Schwegman David J.
Published: January 2025

Local economic development programs, which provide financial support to attract, retain, or expand businesses and increase economic opportunity in local communities, are a powerful tool available for local governments to ameliorate the impacts of systemic underinvestment in particular areas. Using the residential security maps produced by the Home Owners’ Loan Corporation (HOLC) and the Federal Housing Administration (FHA) for Chicago, Illinois, this paper examines the extent to which local economic development funding is being directed to areas that suffered historic (pre-1940s) discrimination and (post-1940s) underinvestment. This author finds that areas designated by the HOLC and FHA as “risky” receive more local economic development funding than “less risky” communities. Moreover, the author finds limited evidence that this local economic development funding is correlated with changes in the median home values of these communities.
Mediating the Cost-of-Living Crisis: The Meaning of a ‘Keyphrase’ in UK Contemporary Cultural Discourse
Authors: Hoff Isaac , Happer Catherine
Published: January 2025

In this article, we draw on Raymond Williams’ notion of ‘keywords’ and Neil Davidson’s conceptualisation of ‘crisis neoliberalism’ to understand how the ‘cost-of-living’ crisis has become a ‘keyphrase’ which sustains, legitimates, reproduces and provides space for a potential challenge to the current social settlement. We draw on illustrative examples from across the UK media – including the ideological construction and naming of crises, Martin Lewis as the leading cost-of-living crisis (COLC) celebrity, discourses around ‘fiscal responsibility’ and the promotion of a socialisation of struggle – to show how mediations of the COLC relate to the current conjuncture, and its priorities. Finally, we argue that because the COLC draws in those newly struggling who are used to having a public voice, the COLC opens up a potentiality in respect of challenge to the hegemonic project of neoliberalism, rather than producing a rerun of the 2007–2008 post-crash landscape in which a coherent financialised media class consolidated to close down all possible alternatives.
Application of machine learning in polyimide structure design and property regulation
Authors: Huo Wenjia , Wang Haiyue , Guo Liying , Zheng Rongrong , Liang Boyang , Wu Xiang , Wang Cheng
Published: January 2025

Polyimide (PI) is widely used in modern industry due to its excellent properties. Its synthesis methods and property research have significantly progressed. However, the design and regulation of PI structures through traditional technologies are slow and expensive, which make it difficult to meet the practical demand of modern materials. With the rapid development of high-throughput computing and data-driven technology, machine learning (ML) has become an important method for exploring new materials. Data-driven ML is envisaged as a decisive enabler for new PIs discovery. This paper first introduces the basic workflow and common algorithms of ML. Secondly, applications of ML in material properties prediction, assisting computational simulation technologies and inverse design for desired structures are reviewed. Finally, we discuss the main challenges and possible solutions of ML in PI research.
Effectiveness, safety, and patient-reported outcomes of bictegravir/emtricitabine/tenofovir alafenamide in routine clinical care in Italy: 12-Month results from the BICSTaR cohort
Authors: Antinori Andrea , Marchetti Giulia , Esposito Vincenzo , Rusconi Stefano , Canetti Diana , Quiros-Roldan Eugenia , Candelaresi Bianca , Saracino Annalisa , Andreoni Massimo , Marongiu Andrea , Cassidy Tali , Thorpe David , Albini Laura , Caldera Roberto , Forcina Gabriele , Di Perri Giovanni
Published: January 2025

Background

BICSTaR is a multi-national, observational cohort evaluating the effectiveness, safety, and patient-reported outcomes (PROs) in treatment-naïve (TN) and -experienced (TE) people with HIV-1 receiving bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in routine clinical care. We present the 12-month (M12) outcomes of the Italian BICSTaR cohort.

Methods

Participants initiating B/F/TAF in routine care were prospectively followed. Outcomes included virological and immunologic effectiveness, drug-related adverse events (DRAEs), treatment persistence, and PROs using the HIV Symptom Index (HIV-SI) and the HIV Treatment Satisfaction Questionnaires (HIVTSQ).

Results

N = 201 were included (29 TN, 172 TE), 83% male, median age 38 years in TN, 48 years in TE. At baseline, 94% of TE had an HIV-1 RNA <50 cp/mL, 92% switched to B/F/TAF for simplification. Overall, 69% reported comorbidities (TN: 59%, TE: 70%). At M12, 88% (23/26) of TN and 96% (152/159) of TE had an HIV-1 RNA <50 cp/mL in the discontinuation = failure analysis (without emergence of resistance to B/F/TAF). Median CD4 count changes were +296 cells/µL (interquartile range [IQR], 118, 383) in TN, and +23 cells/µl (−137, 114) in TE. DRAEs were reported for 5% and led to discontinuation in 1%. M12 persistence on B/F/TAF was 97%. TN had a median HIV-SI bothersome symptom count decrease of −1.5 (IQR, −5.0, 0.0). Median treatment satisfaction change score was +29.0 (21, 30) in TE indicating an improvement.

Conclusions

In this real-world Italian cohort of mostly treatment-experienced people switching for simplification, B/F/TAF demonstrated high effectiveness and persistence over 12 months and confirmed the favourable safety profile shown in clinical trials.

Trial registration

European cohort: EUPAS22185.
The Influence of Pigments on the Dimensional Stability of Moulded Platest†This paper was first presented at Addcon '98, held on 9th-10th November 1998 in London
Authors: Tomlins P.E. , Banyard J. , Butler B. , Lord G.
Published: January 2025

Many of the vibrantly coloured inorganic pigments prized for their colour fastness and thermal stability contain heavy metals such as cadmium and are being, or have been, phased out because of their environmental unacceptability. Some of the organic pigment replacements are renowned for causing dimensional instability in mouldings, particularly those manufactured from polyolefins. This study assesses the influence that pigments have on the in-plane shrinkage and warpage and out-of-plane distortion of a square plate moulding manufactured from high density polyethylene. Variables such as plate thickness and post-moulding treatment are considered, in addition to colour.
Investigation of a Novel Curing Agent for Novolac Resins*This paper was first presented at Addcon '98 on 9th-10th November 1998, held in London, UK
Authors: Hadef A. , Taoudoucht A.
Published: January 2025

This present study represents an attempt to assess degraded polyacetal resin as a curing agent for novolac resins.

First, degraded polyacetal was obtained by extrusion of virgin DELRIN®. Secondly, it was investigated for its reactivity with novolacs by torque rheometry analysis, by differential scanning calorimetry (DSC) and by a solubility test. Once the ability of degraded polyacetal to cure novolac resin was confirmed, the thermal decomposition behaviour of degraded polyacetal and hexamethylene tetramine (HMTA) were compared by thermogravimetric analysis (TGA). The results show that degraded polyacetal decomposes at higher temperatures and at lower rates than HMTA.

As expected from the TGA results, the extent of prior degradation of polyacetal affects its curing capability. The best curing performance (in terms of curing rate, degree of cure and impact strength) was obtained with the most degraded polyacetal product.

Finally, in order to establish the optimum conditions for the use of degraded polyacetal as a curing agent for novolac resins, the effects of polyacetal content and processing temperature were investigated.