bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro and In Silico Anticyclooxygenase and Antitopoisomerase Activity of Anonna cherimola Ent-Kaurenes
Authors: Camacho-González Carlos Eduardo , Pérez-Larios Alejandro , Sáyago-Ayerdi Sonia G. , Salazar-Mendoza Jasmin , Sánchez-Burgos Jorge A.
Published: September 2024

Annona cherimola is noted for its bioactive compounds, particularly diterpenes called ent-kaurenes, which exhibit various biological activities. This study focused on evaluating the ability of ent-kaurenes from Annona cherimola to inhibit cyclooxygenase (COX) and topoisomerase (TOP) enzymes. Researchers used solvent-free lipophilic eluates (SFLEs) from the plant in enzymatic assays and a yeast model. The major compounds in SFLE were identified using gas chromatography–mass spectrometry (GC-MS), and in silico studies explored their inhibition mechanisms. SFLE showed significant inhibition of COX-II (95.44%) and COX-I (75.78%) enzymes and fully inhibited the yeast strain. The effectiveness of inhibition is attributed to the compounds’ structural diversity, lipophilicity, and molecular weight. Two main compounds, kauran-16-ol and isopimaral, were identified, with in silico results suggesting that they inhibit COX-II by blocking peroxidase activity and COX-I by interacting with the membrane-binding region. Additionally, these compounds allosterically and synergistically inhibit TOP-II and potentially sensitize cancer cells by interacting with key amino acids. This research is the first to identify and evaluate kauran-16-ol and isopimaral in silico, suggesting their potential as anti-inflammatory and anticancer agents.
A Systematic Review of Economic and Concrete Support to Prevent Child Maltreatment
Authors: Cusick Gretchen , Gaul-Stout Jennifer , Kakuyama-Villaber Reiko , Wilks Olivia , Grewal-Kök Yasmin , Anderson Clare
Published: September 2024

The association between poverty and maltreatment is well established, and numerous studies show the detrimental effects of economic and material hardship on maltreatment, child welfare involvement, and family well-being. In turn, an increasing body of literature suggests the value of programs and services that provide economic and concrete support in stabilizing and supporting families and, ultimately, reducing occurrences of maltreatment. In this article, we examine the effectiveness of economic and concrete support in reducing primary outcomes of child maltreatment and child welfare involvement and in improving secondary outcomes of child and adult well-being through a systematic review of the literature. We review studies published between 1990 and 2023 through searches of scholarly databases, child welfare websites, and evidence-based clearinghouses. We used a two-stage review process to identify a final sample of articles for data extraction. Twenty-four studies with low risk of bias were included in the synthesis. Regardless of delivery mechanism, we found consistent, favorable evidence of the impact of economic and concrete support as a prevention strategy to reduce child maltreatment and child welfare entry and to a lesser extent, improvements in child and adult well-being across these studies. Implications for policy, practice, and racial equity are discussed.
Crip Digital Intimacies: The Social Dynamics of Creating Access through Digital Technology
Authors: Johnson Megan A. , Chandler Eliza , Jones Chelsea Temple , East Lisa
Published: September 2024

Disabled people are uniquely positioned in relation to the digital turn. Academic ableism, the inaccessibility of digital space, and gaps in digital literacy present barriers, while, at the same time, disabled, Deaf, and neurodivergent people’s access knowledge is at the forefront of innovations in culture and crip technoscience. This article explores disability, technology, and access through the concept of crip digital intimacy, a term that describes the relational and affective advances that disabled people make within digital space and through digital technology toward accessing the arts. We consider how moments of crip digital intimacy emerged through Accessing the Arts: Centring Disability Perspectives in Access Initiatives—a research project that explored how to make the arts more accessible through engaging disabled artist-participants in virtual storytelling, knowledge sharing, and art-making activities. Our analysis tracks how crip digital intimacies emerged through the ways participants collectively organized and facilitated access for themselves and each other. Guided by affordance theory and in line with the political thrust of crip technoscience, crip legibility, and access intimacy, we argue that crip digital intimacy emphasizes the interdependent and relational nature of access, recognizes the creativity and vitality of nonnormative bodyminds, and understands disability as a political—and frequently transgressive—way of being in the world.
Research Duos: Unveiling the Collaborative Essence of Research
Authors: Glebova Ekaterina
Published: September 2024

Through an integrative literature review and theory adaption approach, this research aims to shed light on the efficacy of research partnerships and their implications for academic scholarship and knowledge production. Adapting the concept of creative duos to research activities presents a promising avenue for interdisciplinary collaboration and enhanced productivity. This review explores the application of research partnerships, akin to creative duos, in academic contexts. Research duos involve pairs of scholars who collaborate closely to investigate specific topics, address complex problems, or advance knowledge within their respective fields. This paper delineates the characteristics and potential benefits of research duos, drawing parallels to creative partnerships in various artistic domains. Additionally, it examines the advantages and disadvantages of researching in duos, roles within partnerships, the possible role of artificial intelligence as a partner within a duo, and factors contributing to successful research collaborations and identifies best practices for forming and sustaining effective research duos. By recognizing duos as the fundamental unit of collaborative research, we can understand how their inherent strengths contribute to the effectiveness of larger groups, supporting efficient communication, strong interpersonal bonds, and clear organizational structures.
How Screen Time and Social Media Hyperconnection Have Harmed Adolescents’ Relational and Psychological Well-Being since the COVID-19 Pandemic
Authors: Tintori Antonio , Ciancimino Giulia , Cerbara Loredana
Published: September 2024

Following the COVID-19 pandemic, the increase in screen time and hyperconnection on social media is raising significant concerns, with particular emphasis of their effects on the relational and psychological well-being of children and adolescents. The present study analyses data from two representative cross-sectional surveys conducted among Italian adolescents in 2019 and 2022. Through bivariate analyses and binary logistic regression models, the study examines changes in screen time on social media, identifies key socio-demographic predictors of hyperconnection, and explores its effects on both the relational and psychological well-being of young people. The findings reveal the profound impact of the pandemic on daily social media use, showing a significant increase across all social groups regardless of socio-demographic characteristics, with girls consistently exhibiting higher levels of hyperconnection. Additionally, the results indicate that hyperconnected individuals are 1.4 times more likely to experience negative psychological states compared to their peers. The effects of hyperconnection vary by gender, influencing both horizontal and vertical social interactions, reducing trust in adult figures, increasing the likelihood of cyberbullying victimisation, phubbing, and body image concerns, and fostering the belief that online relationships can replace offline ones. Overall, the study highlights the urgent need for more effective prevention, awareness, and educational strategies aimed at educators, parents, and adolescents.
Conflict in Love: An Examination of the Role of Dark Triad Traits in Romantic Relationships among Women
Authors: Furtado Beatriz Ferrarini , Anacleto Geovana Mellisa Castrezana , Bonfá-Araujo Bruno , Schermer Julie Aitken , Jonason Peter K.
Published: September 2024

The present study examined how the personality dimensions of the Dark Triad (i.e., Machiavellianism, narcissism, and psychopathy) predict infidelity intentions and jealousy and whether these variables predict conflict tactics used in relationships. Adult women (N = 567, 18–73 years old, Mage = 31.91; SD = 10.29) completed self-report scales assessing the Dark Triad traits, jealousy (i.e., cognitive, emotional, and behavioral), intentions towards infidelity, and conflict tactics, including negotiation, psychological aggression, physical assault, sexual coercion, and injury. Our results demonstrated that the Dark Triad traits had strong links to the intention to commit infidelity and jealousy, and at the correlational level, there were small correlations between jealousy and the intention to commit infidelity. Both jealousy and the intention to commit infidelity predicted conflict tactics. As this is possibly one of the first studies to examine these variables jointly, the present results add to our understanding of the role of personality in romantic relationships.
Green Innovation Driven by Digital Transformation: An Innovation Chain Perspective
Authors: Dong Chenguang , Shen Yang , Geng Guobin
Published: September 2024

Taking the innovation chain (IC) as the perspective, we discuss the effect of digital transformation (DT) on enterprises’ green innovation (GI) using data from Chinese listed companies from 2013 to 2021. The results show that DT has a positive effect on enterprises’ GI, and this effect is not only reflected in the quantity of green patent applications but also the GI efficiency and quality. Heterogeneity analysis shows that DT has a positive effect on GI for both large firms and small and medium-sized enterprises (SMEs), but the effect is greater for SMEs. Relative to enterprises that have received governmental incentive-based industrial policies, the effect is smaller in the enterprises that have no incentive-based industrial policies and are subjected to command-based environmental regulations. As the level of industry competition increases from low to high, the impact of DT on GI will grow. However, when the level of industry competition becomes excessively high, the impact will decrease. DT positively affects enterprises’ GI behaviors by facilitating the cultivation of human capital, improving the allocation of innovation resources, and increasing the level of cooperative green innovation.
Three-Dimensional Quantum Black Holes: A Primer
Authors: Panella Emanuele , Pedraza Juan F. , Svesko Andrew
Published: September 2024

We review constructions of three-dimensional ‘quantum’ black holes. Such spacetimes arise via holographic braneworlds and are exact solutions to an induced higher-derivative theory of gravity consistently coupled to a large-c quantum field theory with an ultraviolet cutoff, accounting for all orders of semi-classical backreaction. Notably, such quantum-corrected black holes are much larger than the Planck length. We describe the geometry and horizon thermodynamics of a host of asymptotically (anti-) de Sitter and flat quantum black holes. A summary of higher-dimensional extensions is given. We survey multiple applications of quantum black holes and braneworld holography.
Impact of Anti-SARS-CoV-2 Vaccination on Disease Severity and Clinical Outcomes of Individuals Hospitalized for COVID-19 Throughout Successive Pandemic Waves: Data from an Italian Reference Hospital
Authors: Mondi Annalisa , Mastrorosa Ilaria , Navarra Assunta , Cimaglia Claudia , Pinnetti Carmela , Mazzotta Valentina , Agresta Alessandro , Corpolongo Angela , Zolezzi Alberto , Al Moghazi Samir , Loiacono Laura , Bocci Maria Grazia , Matusali Giulia , D’Annunzio Alberto , Gallì Paola , Maggi Fabrizio , Vairo Francesco , Girardi Enrico , Antinori Andrea
Published: September 2024

This is a retrospective observational study including all COVID-19 patients admitted at our Institute throughout three successive pandemic waves, from January 2021 to June 2023. The main in-hospital outcomes (clinical progression [CP], defined as admission to Intensive Care Unit [ICU]/death, and death within 28 days) were compared among participants unvaccinated (NV), fully vaccinated (FV), with one (FV&B1) and two (FV&B2) booster doses. Vaccinated participants were stratified into recently and waned FV/FV&B1/FV&B2, depending on the time elapsed from last dose (≤ and >120 days, respectively). There were 4488 participants: 2224 NV, 674 FV, 1207 FV&B1, and 383 FV&B2. Within 28 days, there were 604 ICU admissions, 396 deaths, and 737 CP. After adjusting for the main confounders, the risk of both in-hospital outcomes was reduced in vaccinated individuals, especially in those who received the booster dose (approximately by 36% for FV and >50% for FV&B1 and FV&B2 compared to NV). Similarly, after restricting the analysis to vaccinated participants only, we observed a risk reduction of approximately 40% for FV&B1 and 50% for FV&B2, compared to FV, regardless of the distance since the last dose. Our data confirm the vaccine’s effectiveness in preventing severe COVID-19 and support the efforts to increase the uptake of booster doses, mainly among older and frailer individuals, still at a greater risk of clinical progression.
Chalkbrood Disease Caused by Ascosphaera apis in Honey Bees (Apis mellifera)—Morphological and Histological Changes in Infected Larvae
Authors: von Knoblauch Tammo , Jensen Annette B. , Mülling Christoph K. W. , Aupperle-Lellbach Heike , Genersch Elke
Published: September 2024

Chalkbrood is a mycological brood disease of the Western honey bee (Apis mellifera), caused by the fungus Ascosphaera apis. The aim of this study was the investigation of the pathology of artificially reared Apis mellifera larvae, experimentally infected with A. apis spores (1.0 × 103 spores/larva). Non-infected larvae served as control. Five living larvae and every dead larva were collected daily (day 1–7 p.i.). All larvae were macroscopically measured, photographed, formalin-fixed, and histologically processed (hematoxylin-eosin stain, Grocott silvering). Histological sections were digitized, and the size of the larvae was measured (mouth-after length, area) and statistically analyzed. Twenty-six larvae from the collected larvae (n = 64; 23 dead, 3 alive) showed histological signs of infection from 3 d p.i. onwards. The dead larvae showed macroscopically white/brown deposits, indistinct segmentation, and a lack of body elongation. Infected larvae were significantly smaller than the controls on days 3 p.i. (p < 0.05), 4 p.i. (p < 0.001), and 6 p.i. (p < 0.05). The early time of death, the low number of transitional stages, and the strong penetration of the larval carcass with fungal mycelium indicate a rapid and fulminant infection process, which is probably relevant for spreading the disease within the colony.
A Novel Battery Temperature-Locking Method Based on Self-Heating Implemented with an Original Driving Circuit While Electric Vehicle Driving: A Numerical Investigation
Authors: Li Wei , Xiong Shusheng , Shi Wei
Published: September 2024

In extremely cold environments, when battery electric vehicles (BEVs) are navigating urban roads at low speeds, the limited heating capacity of the on-board heat pump system and positive temperature coefficient (PTC) device can lead to an inevitable decline in battery temperature, potentially falling below its permissible operating range. This situation can subsequently result in vehicle malfunctions and, in severe cases, traffic accidents. Henceforth, a novel battery self-heating method during driving is proposed to maintain battery temperature. This approach is ingeniously embedded within the heating mechanism within the motor driving system without any necessity to alter or modify the existing driving circuitry. In the meantime, the battery voltage can be regulated to prevent it from surpassing the limit, thereby ensuring the battery’s safety. This method introduces the dead zone into the space vector pulse width modulation (SVPWM) algorithm to form the newly proposed dSVPWM algorithm, which successfully changes the direction of the bus current in a PWM period and forms AC, and the amplitude of the battery alternating current (AC) can also be controlled by adjusting the heating intensity defined by the ratio of the dead zone and the compensation vector to the original zero vector. Through the Simulink model of the motor driving system, the temperature hysteresis locking strategy, grounded in the field-oriented control (FOC) method and employing the dSVPWM algorithm, has been confirmed to provide controllable and sufficiently stable motor speed regulation. During the low-speed phase of the China Light Vehicle Test Cycle (CLTC), the battery temperature fluctuation is meticulously maintained within a range of ±0.2 °C. The battery’s minimum temperature has been successfully locked at around −10 °C. In contrast, the battery temperature would decrease by a significant 1.44 °C per minute without the implementation of the temperature-locking strategy. The voltage of the battery pack is always regulated within the range of 255~378 V. It remains within the specified upper and lower thresholds. The battery voltage overrun can be effectively avoided.
ANALISIS NOVEL RE: KARYA MAMAN SUHERMAN BERDASARKAN PENDEKATAN FEMINISME
Authors: Oktavia Utami Putri , Kusyani Diah , - Arianto
Published: September 2024

Feminism comes from the Latin femina or woman. The term began to be used in the 1890s, referring to the theory of equality between men and women and the movement to obtain women's rights. This research uses a library research design. The subject of this research is the novel Re: by Maman Suherman. The object of research is feminism found in the novel Re: by Maman Suherman. Important data will be the subject of this research is marked and recorded to be grouped according to feminism, and the struggle of Re: which will be researched. This study found that there are 1 aspect that discusses feminism which is described as part of the right to freedom, 1 aspect that discusses the struggle in the field of education, 0 aspects that discuss the struggle in civil rights, 2 aspects that discuss the struggle in the economic field, 8 aspects that discuss the struggle in the right to express opinions, and 5 aspects that discuss the struggle in the right to assemble. This research aims to describe the study of feminism and describe the struggle of Re: in realizing feminism in the novel Re: by Maman Suherman. As a literary work, novels can be used as a lesson. One of the novels that can be used as learning is the novel Re: by Maman Suherman, which can be utilized to add insight into feminism. This novel can be implied by providing sexual direction or learning from an early age, because the counseling can be used as a guide so that unwanted things do not happen.
Analisis Pola Faktor Penyebab Balita Stunting Pada Dinas Kesehatan Kota Bekasi Menggunakan Algoritma FP-Growth
Authors: Khoirunnisaa Nabiilah , Priatna Wowon , - Rasim , Warta Joni
Published: September 2024

Stunting is a common long-term nutritional problem among children under five, especially in developing countries, including Indonesia. Recently, the term stunting has become a popular topic of discussion while diverting attention from the problems of malnutrition and obesity. This study aims to determine the results of the formation of rules or association rules in determining the causal factors that most affect stunting in toddlers at the Bekasi City Health Office. The method that will be used in this research is the FP-Growth Algorithm. With the application of the FP-Growth Algorithm, accurate results can be obtained in determining the rules for determining the causal factors that most affect stunting in toddlers. The dataset has 4575 data and will be evaluated using the lift ratio. This research produces 26 rules, the best of which are Not Getting Exclusive Breastfeeding, Thinness, and Malnutrition, with a minimum support value of 0.5, a confidence value of 0.6, and a lift ratio of 1.17. Thus, applying the FP-Growth Algorithm in this study is effective because it achieves a lift ratio value of more than 1.
Analisis Implementasi Metode Fuzzy Tsukamoto Dalam Penentuan Calon Legislatif
Authors: Salim Stanley , - Sutrisno , Laia Yonata , Ompusunggu Elvis sastra , Barus Ertina Sabarita , Sihombing Oloan
Published: September 2024

Being elected as a legislative candidate is a challenging matter. Of course, you must know in the field of politics, both locally and globally, qualified leadership attitudes, moral values, and integrity, financially and financially established in order to carry out campaigns and have a base of followers so that all visions and programs can be conveyed to the public as a whole and clearly. Voters are also required to be wiser and more selective in choosing quality legislative candidates, given that the eligibility rate of candidates in Indonesia is still relatively low, and many participants still need to meet the criteria as ideal legislative candidates. Therefore, a technology and support system is needed that can sort and help the general public in determining quality candidates; in this case, the Tsukamoto Fuzzy method is used, which can be a solution in providing competent candidate recommendations because it has the characteristics of shortening time and simplifying the selection process objectively. This fuzzy method is a support system that is very
Pengaruh Dukungan Sosial Terhadap Optimisme Masa Depan Anak Berhadapan Dengan Hukum (ABH) Di Jabodetabek
Authors: Anisa Adelya Shofa , Sumiati Neneng Tati
Published: September 2024

Seeing the number of Children Against the Law (ABH) in Indonesia and the importance of optimism for the future of ABH, this study aims to examine the effect of social support on the future optimism of Children Against the Law in Jabodetabek. The research method used was quantitative, involving 176 Children Against the Law (ABH) categorized as perpetrators in Jabodetabek selected through non-probability sampling techniques, specifically purposive sampling. The questionnaire used contains modifications of the Life Orientation Test-Revised (LOT-R) measuring instrument and instruments compiled by researchers based on the theory of Sarafino and Smith (2011). Test the validity of each questionnaire item using Confirmatory Factor Analysis (CFA), while Multiple Regression Analysis tests the effect of independent variables on the dependent variable. The results showed that ABH's future optimism was significantly influenced by social support by 43.4%. However, based on hypothesis testing regarding the significance of each independent variable regression coefficient, only two social support variables significantly influenced optimism, namely emotional support (sig. 0.029 < 0.05) and information support (sig. 0.00 < 0.05). In contrast, instrumental support and friendship did not significantly influence optimism. The results of this study can be used as a basis for creating programs aimed at increasing ABH's future optimism.
Pengaruh Subjective Well-Being Terhadap Kinerja Karyawan Di PT. X Di Jakarta
Authors: Adeline Aurelia , Basaria Debora , Fahlevi Reza
Published: September 2024

This study explores subjective well-being's influence on employee performance at PT X, a company in the building chemical industry sector in Jakarta. This research is based on the importance of employee well-being in achieving optimal performance and how subjective well-being can be a determining factor, as supported by several studies that show a positive influence between subjective well-being and performance. Initial observations showed high employee performance results, with most employees able to complete work quickly and precisely, as well as a work atmosphere full of happiness and positive emotions based on the results of an initial survey of 30 employees. This study used a quantitative approach with data collected through an online questionnaire distributed to 165 employees of PT X. The instruments used included the Satisfaction With Life Scale (SWLS) and Scale of Positive and Negative Experience (SPANE) to measure subjective well-being, as well as the Individual Work Performance Questionnaire (IWPQ) to measure employee performance. Using a simple regression test, the analysis results obtained an R square value of 9.7% and a significance level of p < 0.05, indicating that subjective well-being significantly affects the employee performance of PT X in Jakarta.
Pengaruh Growth Mindset Terhadap Employee Resilience di Unit Foods PT X
Authors: Aurellia Patricia , Basaria Debora , Fahlevi Reza
Published: September 2024

PT X is one of the companies engaged in Fast Moving Customer Goods (FMCG) in Indonesia, located in Jakarta. The achievement of PT X certainly must maintain the role of qualified employees so that the company can increase its productivity, efficiency, and competitiveness to excel in competition in the era of globalization. The intense competition in the FMCG industry encourages PT X's Foods unit employees to withstand pressure and rise from failure to continue to grow. To encourage employee performance, PT X applies several values to support the effectiveness of employee performance in achieving targets, one of which is a growth mindset. Some previous research results show ambiguity in the relationship between a growth mindset and employee resilience. Therefore, this study aims to determine the effect of a growth mindset on employee resilience in the PT X Foods unit. Research data were obtained through the distribution of Google Forms to 87 employees who met the criteria for research characteristics. The results of this study's data analysis indicate an effect of a growth mindset on employee resilience in the Foods unit of PT X with a Sig value. 0,000 < 0,05. In addition, the coefficient of determination shows that the effect of growth mindset on employee resilience is 15%, while other variables influence the remaining 85%.
Elaboração e caracterização de estruturados da polpa concentrada de amora preta
Authors: Faria Ana Paula de Oliveira , Faria Marco Aurélio da Silva , Campolina Gabriela Aguiar , Dias Juliana Maria da Silva , Viana Pollyanna Amaral
Published: September 2024

As frutas vêm apresentando destaque no agronegócio brasileiro, com o desenvolvimento de novos produtos. A amora preta é cultivada no Brasil, porém por ser perecível não possui alto valor comercial, estando associada a diversos benefícios à saúde como, prevenção de doenças, entre elas, diabetes, infarto, aterosclerose e pressão alta, devido à presença de antocianinas, ácido elágico e taninos. Dentre as técnicas de processamento, a estruturação de polpa de frutas representa uma inovação na área de alimentos, com resultados promissores. Estruturados da polpa de amora preta foram obtidos empregando-se diferentes combinações de glicerol/glicose com os hidrocoloides, pectina, gelatina, alginato de sódio e ágar-ágar, avaliando as características físico-químicas (pH, acidez titulável, umidade, °Brix, cinzas, lipídeos, proteínas, açúcar redutor e não-redutor) e microbiológicas, da polpa e dos estruturados (F1 a F6). A análise sensorial foi realizada com os estruturados F5 (glicose/pectina/gelatina) e F6 (glicerol/pectina/gelatina). A estruturação da polpa de amora preta garantiu redução considerável do teor de umidade e acidez titulável e, aumento no teor de açúcares redutor e não redutor, °Brix, pH e cinzas, comparando-se com os resultados da polpa. Como o estruturado F5 teve média superior ao F6 para os atributos sensoriais, impressão global e textura, e para intenção de compra, isso indica que, os avaliadores tiveram maior aceitação para os estruturados contendo gelatina, pectina e glicose. A estruturação da polpa concentrada de amora preta obteve produtos com maior durabilidade, praticidade para consumo da fruta estruturada como sobremesa, podendo ser utilizada em caldas, sorvetes, recheios de iogurtes ou produtos de confeitaria.
Delirium em unidade de terapia intensiva: uma revisão abrangente
Authors: Rapozero João Felippe Donaire , Oliveira Eduardo Camilo de , Obeid Maruan , Ribeiro Lucas Oliveira Pinto , Rocini Emily Rovaris Cesario
Published: September 2024

O delirium é uma síndrome neuropsiquiátrica prevalente em Unidades de Terapia Intensiva (UTIs), caracterizada por uma confusão mental aguda que surge de uma etiologia multifatorial. Fatores predisponentes, como a idade avançada e comorbidades preexistentes, aumentam significativamente o risco de delirium, enquanto fatores precipitantes incluem o uso de sedativos, infecções e outros estressores ambientais e fisiológicos. A fisiopatologia do delirium é complexa, envolvendo desequilíbrios neurotransmissores, particularmente na acetilcolina e dopamina, inflamação sistêmica e hipóxia cerebral. Diagnosticar o delirium é particularmente desafiador devido à sobreposição de sintomas com outras condições, como demência e transtornos psiquiátricos. Ferramentas como o Confusion Assessment Method for the ICU (CAM-ICU) e a Intensive Care Delirium Screening Checklist (ICDSC) são essenciais para um diagnóstico preciso e oportuno. As estratégias de tratamento para o delirium envolvem uma combinação de abordagens não farmacológicas—como a promoção da higiene do sono, reorientação cognitiva e mobilização precoce—e o uso criterioso de agentes farmacológicos, incluindo antipsicóticos e sedativos, quando necessário. Medidas preventivas são cruciais nas UTIs para minimizar a incidência de delirium e melhorar os desfechos clínicos gerais. O monitoramento regular e a implementação de protocolos de cuidados abrangentes são essenciais para mitigar os efeitos adversos do delirium e aprimorar a recuperação e a qualidade de vida dos pacientes.
Infecções do trato urinário: etiologia, diagnóstico e desafios no tratamento e prevenção
Authors: Radd Luis Gustavo Amaral , Queiroz Giovana Rocha , Ribeiro Giovanna Fortes Carvalho , Lisbôa Leandra Alvarenga , Rodrigues Maria Clara Gomes
Published: September 2024

As infecções do trato urinário (ITUs) são condições prevalentes que afetam uma ampla gama de indivíduos, desde crianças até idosos, com maior incidência em mulheres. Estas infecções ocorrem quando microrganismos, principalmente bactérias, colonizam o trato urinário, podendo afetar desde a uretra até os rins. A distinção entre ITUs simples e complicadas é fundamental para a escolha do tratamento adequado, sendo que as complicadas geralmente estão associadas a anormalidades estruturais, comorbidades ou a utilização de cateteres, o que aumenta o risco de recorrência e resistência antimicrobiana. A etiologia envolve predominantemente a Escherichia coli, embora outros patógenos, como Klebsiella pneumoniae e Proteus mirabilis, também sejam frequentes. O diagnóstico dessas infecções é baseado na avaliação clínica e na análise laboratorial de amostras de urina, destacando-se a urocultura como o padrão-ouro. No entanto, a resistência crescente aos antibióticos comumente utilizados, como trimetoprim-sulfametoxazol e fluoroquinolonas, tem se tornado um desafio significativo no manejo das ITUs, exigindo uma abordagem terapêutica mais cuidadosa e individualizada. A prevenção de ITUs, especialmente em pacientes com infecções recorrentes, abrange tanto intervenções farmacológicas quanto mudanças no estilo de vida. O uso de extratos de cranberry e a adoção de práticas como a ingestão adequada de líquidos e a micção regular após a atividade sexual são estratégias recomendadas. Além disso, o desenvolvimento de vacinas contra ITUs e a prevenção de infecções associadas ao uso de cateteres representam áreas emergentes de pesquisa, com o potencial de reduzir significativamente a incidência e as complicações dessas infecções. Por fim, este artigo aborda os principais aspectos relacionados à etiologia, diagnóstico, tratamento e prevenção das ITUs, destacando os desafios atuais e as perspectivas futuras na gestão dessas infecções. A compreensão dessas questões é essencial para o desenvolvimento de estratégias eficazes que possam mitigar o impacto das ITUs na saúde pública.
Avanços recentes no tratamento da Hepatite Viral: eficácia das terapias antivirais e impacto na prevenção do câncer hepático
Authors: Celestino Priscila Lacerda Oliveira , Silva Ana Clara Bianchi da , Quintela Anna Luiza Batista , Egidio Bárbara Caroline Ganzella , Moura Neto Emidio Pires de , Cortizo Gabriel Silvestre , Souza Letícia Ferreira de , Angioletti Lucas Félix , Chagas Thiago Silva , Cunha Victória Freitas Vieira da
Published: September 2024

Nos últimos anos, os avanços no tratamento da hepatite viral têm promovido melhorias notáveis na eficácia das terapias antivirais e na prevenção do câncer hepático. A introdução de terapias antivirais de ação direta (DAAs) tem sido fundamental para o tratamento da hepatite C, proporcionando altas taxas de cura com regimes terapêuticos mais curtos e menos efeitos colaterais. Esses novos medicamentos têm possibilitado a erradicação do vírus em um número significativo de pacientes, reduzindo a incidência de complicações graves, como a cirrose e o câncer hepático. Além disso, o progresso no tratamento da hepatite B também tem sido notável, com novos antivirais e combinações terapêuticas que melhoram o controle da replicação viral e diminuem a inflamação hepática. Além das terapias antivirais, novas estratégias, como a utilização de interferon peguilado e combinações de medicamentos, têm mostrado resultados promissores. As combinações inovadoras de antivirais têm proporcionado melhores taxas de resposta e menos efeitos adversos, contribuindo para a eficácia geral do tratamento. O impacto dessas terapias antivirais vai além do controle das infecções virais, influenciando diretamente a prevenção do câncer hepático. A erradicação da hepatite C e o controle efetivo da hepatite B têm sido associados a uma redução significativa no desenvolvimento de hepatocarcinoma. A diminuição da carga viral e a redução da inflamação hepática resultam em uma menor incidência de tumores, sublinhando a importância das terapias antivirais não apenas para a gestão da infecção, mas também para a prevenção secundária do câncer hepático. Apesar dos avanços, persistem desafios, como a desigualdade no acesso às novas terapias e a necessidade de monitoramento contínuo para detectar e gerenciar efeitos adversos. A resistência a medicamentos e a variabilidade genética dos vírus ainda apresentam obstáculos importantes para a eficácia universal dos tratamentos.
Síndrome dos Ovários Policísticos: avanços no diagnóstico, fisiopatologia e abordagens terapêuticas
Authors: Alcântara João Pedro Toledo Lima de , Cordeiro Ana Luiza Soares , Nandi Isabella Garcia , Chagas Thiago Silva , Rocha Junio Alves
Published: September 2024

A Síndrome dos Ovários Policísticos (SOP) é um distúrbio endócrino prevalente que afeta 5% a 10% das mulheres em idade reprodutiva, caracterizado pela presença de múltiplos cistos ovarianos e desequilíbrios hormonais, incluindo hiperandrogenemia e resistência à insulina. Desde sua descrição inicial na década de 1930, o conhecimento sobre a SOP evoluiu para incluir uma compreensão detalhada de sua fisiopatologia, que envolve resistência à insulina, inflamação crônica e disfunção do eixo hipotálamo-hipófise-ovário. O diagnóstico é baseado em critérios clínicos e ultrassonográficos, com a avaliação de sintomas como ciclos menstruais irregulares, hirsutismo e acne, complementada por exames laboratoriais para confirmar hiperandrogenemia e resistência à insulina. O tratamento da SOP é multifacetado, envolvendo mudanças no estilo de vida, manejo farmacológico com contraceptivos orais e medicamentos para resistência à insulina, além de suporte psicológico para lidar com os aspectos emocionais da condição. O progresso contínuo na pesquisa e no tratamento promete aprimorar as abordagens terapêuticas, oferecendo melhores opções para a gestão eficaz da SOP e para a melhoria da qualidade de vida das mulheres afetadas.
Conhecendo o MINOCA: infarto do miocárdio com artérias coronárias não obstrutivas
Authors: Perissê Rafaella Afonso Tormin , Oliveira Yasmmin Linda de , Rodrigues Samara Cabral , Silva Victor Franco de Azevedo , Rocha Camila de Oliveira , Chaves Marcela Pessoa , Rezende Amanda Oliveira de , Sampaio Laurha Helena Faustino , Oliveira Vinícius Feijó de , Cruz Amanda Cristina Alves da , Peres Neto Gilberto de Almeida , Lima Ana Beatriz Paz , Andriani Lucas , Lira Lorenna Cristina Leite , Gaia Maria Luísa Vieira , Silva Felipe Nogueira Affiune , Vaz Mariana Gomes de Morais , Silva Caio Nogueira Affiune , Silva Glauco Giuliano Lima da , Zanetti Karina Lasmar Sampaio , Rodrigues Henia Coelho
Published: September 2024

Objetivos: Neste artigo propomos um estudo que visa entender O MINOCA (Infarto do Miocárdio com as Artérias Coronárias não Obstruiídas), bem como sua etiologia e fisiopatologia. Métodos: Revisão de literatura de caráter exploratório, com uma avaliação integrativa de artigos, em que se fez uma análise do MINOCA e seu quadro clínico. Resultados: Foram selecionados 20 estudos para compor essa revisão de literatura. Entre as bases de dados selecionadas estão: PubMed, Google Scholar e SciELO. Discussão: A MINOCA é uma síndrome pelo qual há um infarto sem a obstrução das artérias coronárias. Dentro da síndrome, há três grupos principais: Causas epicárdicas, microvasculares e miscelâneas. Porém, dentro de cada grupo há diversas etiologias que podem ser consideradas, cada uma com sua individualidade tanto no diagnóstico como no tratamento. Conclusão: Concluiu-se que a síndrome MINOCA é um enigma tendo em vista suas diversas etiologias e a diferença de diagnóstico de cada uma dela e o fato de não haver critérios para o seu diagnóstico, dificultando assim seu tratamento adequado e consequentemente o prognóstico do paciente.
Síndrome de Takotsubo na pediatria: uma revisão de literatura
Authors: Oliveira Yasmmin Linda de , Perissê Rafaella Afonso Tormin , Rodrigues Samara Cabral , Silva Victor Franco de Azevedo , Silva Ana Beatriz de Morais Emerick , Rezende Amanda Oliveira de , Moraes Amanda Silva de , Leandro Akemi Kudo e , Silva Laura Teresa Lopes , Medeiros Priscila Sereno de , Pereira Maria Eduarda Wassouf , Ferro Ana Carolina Linhares Lima , Alves Ana Luiza Pereira , Penna Marina Carvalho Robichez , Rodrigues Ana Clara Mariano , Crivellaro Anna Clara de Lima , Rodrigues Henia Coelho , Souza Rodrigo Queiroz de
Published: September 2024

Considerando que a síndrome de Takotsubo é um diagnóstico diferencial relevante na abordagem de sintomas cardiorrespiratórios na emergência, o presente artigo tem como objetivos revisar os dados sobre essa síndrome na pediatria disponíveis na literatura e reforçar a possibilidade dessa condição como hipótese durante as avaliações diagnósticas. Dessa forma, foi realizada uma revisão de literatura de caráter exploratório com estudos selecionados nas plataformas PubMED, Google Scholar e SciELO, no período de 2018 a 2024. Foram elegidos, após a aplicação dos critérios de seleção e exclusão, 11 artigos para a leitura completa e adicionados 11 materiais extras de valor para o estudo, totalizando uma revisão de 22 artigos. A análise entre os estudos permitiu observar-se que a síndrome de Takotsubo é uma condição caracterizada por uma disfunção ventricular esquerda transitória grave que, geralmente, é desencadeada por um evento estressante emocional ou físico. As manifestações clínicas incluem início súbito de dor torácica, dispneia, palpitações e síncope. Os exames complementares revelam alterações eletrocardiográficas, laboratório sugestivo de lesão miocárdica e acometimento ventricular na ecocardiografia. O tratamento é baseado no interrompimento dos fatores desencadeantes e manejo do excesso de catecolaminas, que ocorre por conta de mecanismos fisiopatológicos ainda não muito bem esclarecidos. Portanto, conclui-se que a síndrome de Takotsubo deve ser considerada em crianças que apresentam sintomas cardiopulmonares com alterações eletrocardiográficas e elevação de biomarcadores cardíacos. O reconhecimento dessa condição diante de diagnósticos diferenciais como miocardite permite um manejo rápido e eficiente dessa cardiomiopatia.
Prevalência dos casos de esquistossomose na região norte do Brasil entre os anos de 2007 e 2022
Authors: Pimenta Thaís de Angiolis , Souza Filho Paulo Gabriel Cruz de , Franco Tamires Costa , Costa Júnior Claúdio Jackson , Trindade Eliane Leite da , Ferreira Lucas Araújo
Published: September 2024

A Esquistossomose, ou Barriga d’água, é uma parasitose causada por Schistosoma mansoni, sendo predominante em países tropicais e subtropicais. É transmitida através do contado com água contendo as formas infectantes do parasito, chamadas de cercárias, que são liberadas pelo seu hospedeiro intermediário, caramujos do gênero Biomphalaria. Dada a sua gravidade, o monitoramento epidemiológico é fundamental para o direcionamento de ações em saúde. Trata-se de um estudo descritivo, transversal com abordagem quantitativa que usou dados públicos disponíveis no Sistema de Informação de Agravos de Notificação (SINAN) sobre os casos de Esquistossomose no Norte do Brasil entre os anos de 2007 e 2022. Houve 948 casos da patologia notificados ao longo do recorte temporal, onde a predominância de casos confirmados ocorreu nos estados de Rondônia e Pará com 649 e 242 registros, respectivamente. As notificações em alguns anos podem estar associadas a subnotificação em áreas endêmicas, bem como o método diagnóstico utilizado que pode refletir em baixa sensibilidade e, consequentemente, um maior risco de falso-negativos. A Esquistossomose continua sendo um problema severo de saúde pública, onde enfrenta desafios desde o seu controle ao tratamento, assim, é fundamental ações mais direcionadas em saúde.
Relato autobiográfico e simbólico da jornada do eu em momento pandêmico
Authors: Battaglia Claudia Lemos de Pontes , Graciani Juliana Santos , Grandi Eliana Valença , Mercúrio Graziela Fernanda , Miranda Vanelise Michaela Lira
Published: September 2024

O objetivo geral desta pesquisa foi compreender o fenômeno da jornada do eu através de uma investigação do processo de individuação e da análise simbólica de uma mandala autobiográfica, ambos conceitos dispostos na Psicologia Analítica, diante das participantes de um curso de Arteterapia. Os objetivos específicos, abrangeram três aspectos: identificar o processo de individuação das participantes do curso Mandalando: despertar da Mandala Interior, diante da análise do relato autobiográfico; descrever as múltiplas facetas simbólicas da jornada do eu no momento atual, através dos conceitos contidos nos desenhos elaborados pelas participantes; refletir como a arteterapia pode auxiliar no momento de pandemia. Quanto ao método utilizado, consistiu numa pesquisa qualitativa, revisão bibliográfica e análise documental da produção de uma mandala, com a temática jornada do eu e um breve relato autobiográfico do momento atual. Os resultados indicam as vivências de arterapia realizadas por meio da participação no curso Mandalando: despertar da Mandala Interior, pode colaborar no desenvolvimento do processo de individuação dos participantes auxiliando no desenvolvimento do autoconhecimento, transformação pessoal e grupal, na busca pela cura de suas dores, na promoção da auto aceitação, na compreensão da comunicação com o inconsciente, contribuindo para a expansão do ser transcendental e dos propósitos existenciais durante o período da pandemia.
Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands
Authors: Lee Jung Ro , Kim Young-Min , Kim Eun-Ji , Jang Mi-Kyeong , Park Seong-Cheol
Published: September 2024

Although curcumin has been well known as a phytochemical drug that inhibits tumor promotion by modulating multiple molecular targets, its potential was not reported as a targeting ligand in the field of drug delivery system. Here, we aimed to assess the tumor-targeting efficiency of curcumin and its derivatives such as phenylalanine, cinnamic acid, coumaric acid, and ferulic acid. Curcumin exhibited a high affinity for estrogen receptors through a pull-down assay using the membrane proteins of MCF-7, a breast cancer cell line, followed by designation of a polymer-based gene therapy system. As a basic backbone for gene binding, dextran grafted with branched polyethylenimine was synthesized, and curcumin and its derivatives were linked to lysine dendrimers. In vitro and in vivo antitumor effects were evaluated using plasmid DNA expressing anti-
bcl-2
short hairpin RNA. All synthesized gene carriers showed excellent DNA binding, protective effects against nuclease, and gene transfection efficiency in MCF-7 and SKBr3 breast cancer cells. Preincubation with curcumin or 17α-estradiol resulted in a marked dose-dependent decrease in gene transfer efficiency and suggested targeting specificity of curcumin. Our study indicates the potential of curcumin and its derivatives as novel targeting ligands for tumor cells and tissues.
Hubungan perilaku konsumsi nutrisi dengan risiko kejadian preeklamsia
Authors: Mangkuluhur Ando , Azza Awatiful , Kholifah Siti
Published: September 2024

Latar Belakang: Perilaku konsumsi nutrisi ibu hamil merupakan cara makan ibu dan ditentukan oleh faktor lingkungan, sosial dan biologis, seperti keterampilan memasak, preferensi rasa, kebiasaan dan pengetahuan pola hidup sehat. Berdasarkan hasil studi pendahuluan di Puskesmas Gumukmas tahun 2024 didapatkan 72 ibu hamil, 15 orang diantaranya adalah preeklamsia. Penelitian ini bertujuan untuk menganalisis hubungan antara perilaku konsumsi nutrisi dengan risiko kejadian preeklamsia pada ibu hamil di Wilayah Kerja Puskesmas Gumukmas Kabupaten Jember.Metode: Desain penelitian deskriptif kuantitatif dengan metode cross-sectional. Sampel dalam penelitian ini adalah ibu hamil trimester 2 sampai trimester 3 di Wilayah Kerja Puskesmas Gumukmas selama bulan Januari 2024 dengan besar populasi terjangkau sebanyak 50 ibu hamil yang diperoleh dengan teknik cluster random sampling dan data dikumpulkan menggunakan kuesioner.Hasil: Sebagian besar perilaku konsumsi nutrisi ibu hamil di Wilayah Kerja Puskesmas Gumukmas Kabupaten Jember berada pada kategori baik dan tidak berisiko preeklamsia.Kesimpulan: Terdapat hubungan antara perilaku konsumsi nutrisi dengan risiko kejadian preeklamsia.