bluuebunny/crossref_metadata_2025 huggingface dataset:
Problem oporności farmakokinetycznej na ASA
Authors: Rudnicka Magdalena
Published: November 2024

Kwas acetylosalicylowy (ASA) jest podstawowym lekiem przeciwpłytkowym, jednak zaburzenie procesów farmakokinetycznych na etapie wchłaniania może prowadzić do wystąpienia oporności farmakokinetycznej na ASA. Skutkiem tego jest niepełne hamowanie agregacji i zwiększone ryzyko zdarzeń sercowo-naczyniowych. Zjawisko oporności częściej dotyczy pacjentów otyłych, chorych na cukrzycę czy starszych. Jednym ze sposobów przełamywania oporności farmakokinetycznej może być zastosowanie tabletki o natychmiastowym uwalnianiu oraz dodanie substancji, które przyspieszają wchłanianie, takich jak glicyna. Glicyna ponadto ma działanie przeciwzapalne, immunomodulujące i cytoprotekcyjne, co może ograniczać uszkodzenia przewodu pokarmowego związane z terapią ASA. Badania kliniczne wskazują, że suplementacja glicyną może zmniejszać ryzyko wystąpienia choroby sercowo-naczyniowej u pacjentów z zespołem metabolicznym. Zatem u osób z populacji geriatrycznej, otyłych czy chorych na cukrzycę zastosowanie postaci o natychmiastowym uwalnianiu z dodatkiem glicyny może okazać się skuteczną opcją leczenia przeciwpłytkowego.
Profilaktyka i leczenie niedoboru witaminy D dawkami 7000 j.m. i 30 000 j.m.
Authors: Płudowski Paweł , Marcinowska-Suchowierska Ewa
Published: November 2024

Kryteria niedoboru witaminy D oraz stężeń uznawanych za optymalne, czyli 25(OH)D <20 ng/ml oraz ≥30–50 ng/ml, a także dane epidemiologiczne wskazały potrzebę prowadzenia działań profilaktycznych i terapeutycznych w Polsce. Dla osób otyłych, dla pacjentów przewlekle leczonych lekami wpływającymi na metabolizm witaminy D (np. przeciwdrgawkowymi, przeciwretrowirusowymi, glikokortykosteroidami itp.), pacjentów z zespołami złego wchłaniania (np. mukowiscydozą, nieswoistymi zapaleniami jelit, popromiennym zapaleniem jelit, po operacjach bariatrycznych), z niewydolnością wątroby, przewlekłą chorobą nerek, rozmiękaniem kości, z przewlekłymi bólami mięśniowo-szkieletowymi, a także z nadczynnością przytarczyc, chorobami autoimmunizacyjnymi, dla osób w podeszłym wieku (>65 lat), zwłaszcza u seniorów, u których w przeszłości występowały upadki lub złamania niskoenergetyczne (osteoporoza), zaproponowano schematy profilaktyki i terapii niedoboru witaminy D przy użyciu 7000 j.m. i 30 000 j.m. cholekalcyferolu w podaży dobowej lub skumulowanej, z uwzględnieniem bezpieczeństwa.
Praktyczne aspekty terapii reumatoidalnego zapalenia stawów przy użyciu metotreksatu
Authors: Rupiński Robert
Published: November 2024

Metotreksat jest antagonistą kwasu foliowego odgrywającym kluczową rolę w leczeniu wczesnego i zaawansowanego reumatoidalnego zapalenia stawów. Metotreksat odznacza się wysoką skutecznością kliniczną, hamowaniem uszkodzeń strukturalnych, dobrym profilem bezpieczeństwa, możliwością podawania doustnego lub podskórnego oraz niezrównaną efektywnością kosztową. Metotreksat może być stosowany zarówno w monoterapii, jak i jako wiodący lek w połączeniach z innymi syntetycznymi lub biologicznymi lekami modyfikującymi przebieg choroby.
Efficient antiseptic prophylaxis in the era of antibiotic resistance
Authors: Adamiec-Mroczek Joanna , Misiuk-Hojło Marta
Published: November 2024

An excessive use of antibiotic preparations in daily practice frequently without clear medical indications has led to the development of dangerous strains of bacteria resistant to the available pharmaceutical drug. Today, antibiotics are used not only to treat infections, but also as preoperative infection prevention. Intravitreal injection is one of the most commonly performed ophthalmological procedures where, until recently, perioperative antibiotics prevention was recommended. Currently, antibiotics in this procedure are not advised at all. Nowadays, for anti-infective prophylaxis we use iodopovidone and preparations that combine antiseptic and soothing effects.
How does digital transformation affect corporate governance paradigms? A synthesis of the literature
Authors: Sun Yulong , Guo Juancan
Published: November 2024

At present, digital transformation has become a vital way for companies to achieve sustainable growth. This paper reviews the literature on the correlation between digital transformation and corporate governance paradigm, analyzes the specific impact mechanism of AI technology and big data technology in the field of corporate governance, and explores the influence effect of the most popular ChatGPT technology on corporate governance from the perspective of business practice. It is found that digital transformation has an important impact on stakeholder management, information disclosure, green governance and other aspects of corporate governance. The purpose of the study is to provide a new reference for the construction of corporate governance paradigm and help companies achieve long-term development in the digital wave.
Literature review of impacts of mega-sport global events on destination sustainability and sustainability marketing—Reflection on Qatar 2022 FIFA World Cup
Authors: Al-Muhannadi Khawla , Boros Anita , Vinogradov Szergej , Dávid Lóránt Dénes
Published: November 2024

Qatar FIFA 2022 was the first FIFA Football World Cup to be hosted by an Arab state and was predicted by some to fail. However, it did not only succeed but also showed a new display of destination sustainability upon hosting mega-sport events and linked tourism. Yet, some impacts tend to be long-term and need further analysis. The study aims to understand both positive and negative impacts on destination sustainability resulting from hosting mega-sport events, using bibliometric analysis of published literature during the last forty-seven years, and reflecting on the recent World Cup 2022 tournament in Qatar. A total of 2519 sources containing 665 open-access articles with 10,523 citations were found using the keywords “sport tourism” and “mega-sport”. The study found various literature researching the economic impacts in-depth, less on environmental impacts, and much less on social and cultural impacts on host communities. Debates exist in the literature concerning presumed economic benefits and motivations for hosting, and less on actual results achieved. Although World Cup 2022 is considered the most expensive among previous versions, destination sustainability seems to have benefited from the event’s hosting. Socio-cultural impacts of hosting mega-sport events seem to be addressed to an extent in the Qatar version of the World Cup, as well as environmental impacts while creating a unique image for FIFA 2022 and the destination itself. FIFA showcased this as using carbon-neutral technologies to create the micro-climate including perforated walls in the eight state-of-the-art stadiums, with the incorporation of a circular modular design for energy and water efficiency and zero-waste deconstruction post-event. The global event also drew attention and respect to the local community and underprivileged groups such as people with disabilities. Further research is needed to understand the demand-side perspective including the local community of Qatar and the event’s participants, and to analyze the long-term impacts and lessons learned from the Qatari experience.
Examining the sustainable leisure and business values in sporting events and lottery analyses development
Authors: Gau Li-Shiue , Chu Hsiu-Tan , Nguyen Nguyen Phan Thao
Published: November 2024

Purpose: This study aims to clarify the meaning of sport analysis, explore the contributions derived from sporting event analysts, and highlights the importance of responsible sport gambling. It also investigates how sustainable practices can be integrated into sports analysis to enhance social well-being. Design/methodology/approach: Secondary text data from government documents, news articles, and website information were extracted by searching keywords such as sports lottery and sports analysis in traditional Chinese, and then analyzed to establish the research framework and scope. Subsequently, 18 interviews were conducted with stakeholders to gain deeper insights. Findings: The content analyses reveals that sport analysis tends to be sport data science. Sporting event analysts may contribute to improving the performance of players or a team, enhancing spectator sports, and increasing sports lottery revenues. In the leisure aspect, the professionalism of sporting event analysts not only increases epistemic and entertainment values in spectator sports but also boosts engagement with sport lotteries. To ensure these enhancements remain beneficial, it is vital to emphasize responsible sport gambling and sustainable practices that protect vulnerable groups and promote long-term health benefits for those involved in sports. The integration of sustainable practices in sport analysis and the expertise of sporting event analysts can significantly advance economic and social development by generating funds through sport lottery industry for athlete programs, sports infrastructure, and educational initiatives, aligning with multiple Sustainable Development Goals. Additionally, the professionalism of these analysts may enhance public understanding and engagement of sports, promoting increased participation in sports, reducing healthcare costs, and contributing to the development of a healthier and more resilient society. Originality: Emphasizing responsible sports gambling is essential to the sustainability of sports lotteries and the role of sporting event analysts.
A pöszörlegyek magyarországi lelőhelyei, elterjedése és gyakorisága (Diptera: Bombyliidae)
Authors: Tóth Sándor
Published: November 2024

„A pöszörlegyek magyarországi lelőhelyei, elterjedése és gyakorisága (Diptera: Bombyliidae)” című tanulmánykötet, mintegy 60 éves intenzív kutatómunka eredményeképpen állt össze. A kötet bevezető fejezeteiben a szerző részletesen ismerteti a magyarországi pöszörlégy fauna kutatás történetét. A hatalmas adatmennyiség összeállításához 103 gyűjtő működött közre és továbbított példányokat a szerzőnek meghatározásra. A szerző szinte az egész országot lefedő különböző kutatóprogramok aktív résztvevőjeként végezte a terepi gyűjtéseket rovarhálóval és Malaise-csapdák segítségével. Az elmúlt évtizedek alatt országszerte 25 helyen állított fel éves szinten rendszeresen működtetett Malaise-csapdát. Ez a kötet egy olyan ökofaunisztikai alapvetés, amely az elmúlt évtizedekben Magyarországról kimutatott 65 faj, 974 lelőhelyét tartalmazza. A publikált adatok a lelőhelyek felsorolása mellett a példányok mennyiségi és a nemek szerinti eloszlását is tartalmazzák. A fajok hazai elterjedése 10x10 UTM grid ponttérképen van feltüntetve a kisszámú irodalmi adattal együtt. A faunatérképezési adatok alapján a szerző öt gyakorisági kategóriába sorolta a fajokat. A fajok többségének sikerült ábrázolnia a rajzási diagramját is. A fajok ismertetését a viráglátogatási szokásaik információival is kiegészítette. Ez a kötet a következő kutatói generációk számára is egy alapmunka.
Predicting performance and onset criteria of a three-stage double-acting thermoacoustic Stirling oscillator: Analysis and experiment
Authors: Sangdani Mohammad Hossein , Tavakolpour-Saleh Alireza
Published: November 2024

In this paper, a novel analytical approach is proposed to predict the performance and onset criteria of a three-stage double-acting thermoacoustic Stirling oscillator (TDTASO). First, a coupled dynamic-thermodynamic model justifying the behavior of TDTASO is presented, taking into account Schmidt's theory assumptions. Subsequently, the manipulation of the obtained governing equations reveals that the considered Stirling oscillator is a physical regulator system. Thus, the onset criteria, which are the necessary conditions for designing such oscillators, are assessed based on a new analytical method resulting from a regulator-like model. Accordingly, the onset temperature difference is predicted corresponding to different dimensions of the resonator section in the TDTASO. Next, the sensitivity of the TDTASO to the inconsistency of resonators' dimensions is investigated. The results show that increasing the length of the mismatched water column results in a higher frequency. Finally, a prototype TDTASO is constructed and experimentally evaluated. Accordingly, the oscillator frequency is measured 3.14 Hz corresponding to the onset temperature of 163 C and the resonator length of 0.52 m. The experimental data demonstrate the effectiveness of the proposed analytical scheme in predicting the necessary conditions for designing the TDTASO.
Point-of-care viscoelastic coagulation monitoring device shows promise for informing resuscitation strategies in a canine hemorrhagic shock model
Authors: Baird Taylor N. , Zersen Kristin M. , Guillaumin Julien
Published: November 2024

OBJECTIVE

To use a point-of-care viscoelastic coagulation monitoring device (VCM-Vet; Entegrion) and traditional tests to assess hemostatic changes during hemorrhagic shock in dogs.

METHODS

8 healthy, purpose-bred Beagles were enrolled in a hemorrhagic shock model conducted from September through December 2021. Dogs were anesthetized, had baseline hemostatic variables measured after blood pressure was stabilized at 70 to 80 mm Hg for 10 minutes (T1), had blood withdrawn from a jugular vein to achieve a mean blood pressure of 40 ± 5 mm Hg for 10 minutes (T2), were resuscitated with 100% shed blood, and then had hemostatic variables evaluated 10 minutes later (T3). At each time point, hemostatic variables were measured with traditional tests (Hct, WBC count, platelet count, mean platelet volume, prothrombin time, activated partial thromboplastin time [aPTT], and concentrations of fibrinogen, antithrombin, and D-dimer) and the VCM-Vet device (clot time, clot formation time, α-angle, maximum clot formation, amplitude at 10 minutes [A10], amplitude at 20 minutes [A20], clot lysis index at 30 minutes [LI30], and clot lysis index at 45 minutes [LI45]).

RESULTS

All dogs survived without complication. At T2 and T3 (vs T1), samples had significantly higher coagulability (increased median α-angle, A10, and A20) and fibrinolysis (decreased median LI30 and LI45) and significantly longer aPTT; however, all values remained within reference limits.

CONCLUSIONS

The use of VCM-Vet helped identify complex hemostatic disturbances in dogs with hemorrhagic shock.

CLINICAL RELEVANCE

The use of VCM-Vet shows promise in aiding veterinarians in optimizing resuscitation strategies based on real-time clotting data.
Development of Multiple Representation Learning Videos on Hydrocarbon Nomenclature
Authors: Fatmala Fatmala , Lestari* Ira , Enawaty Eny , Hairida Hairida , Erlina Erlina
Published: November 2024

This research focuses on the development of learning media based on multiple representations in organic chemistry courses. Multiple representation-based learning media has the potential to improve students understanding of the concepts of chemical materials that are often considered difficult. However, the lack of learning media used by lecturers to discuss the three aspects of representation is a problem that needs to be addressed. This research aims to produce a nomenclature of hydrocarbon compounds learning video based on multiple representations and to find the eligibility and response for the developed learning video. The research methods are research and development using the 4d development model. The instruments used were the eligibility sheet and response questionnaire using a Likert scale. The eligibility for learning video is included as very feasible, with an average eligibility percentage of 95,03%. The eligibility of learning video was viewed in three aspects, namely, the lesson aspect (94.67%), the language aspect (95.56%), and the media aspect (94.87%). The responses given by students were included as a good category, as shown by the percentage of response results on the small-scale trial of 83,79% and large-scale trial of 83,31%. Based on the outcome of eligibility assessment and field trials, the nomenclature of hydrocarbon compounds learning video based on multiple representations is very feasible for learning media in the organic chemistry of monofunctional compounds course.
Enhancing Students' Science Process Skills Through Design Worksheet-Based Inquiry Integrated PhET Simulation on Acid and Base Material
Authors: Buhera* Rusdiman , Ayu Sri Bona , Nurohman Sabar
Published: November 2024

Integrating PhET on inquiry-based worksheets can foster a more interactive and hands-on learning environment that encourages active student participation throughout the educational process. The research aims to develop an integrated inquiry-based worksheet PhET simulation. This research type is RD, using the 4-D model, which designs learning activities to enhance science process skills. The validators totaled four people, including media experts, content experts, and two practitioners. The readability test uses ten for 9th-grade students. The research findings indicate that the worksheets created have a very high average validity, with an Aiken V value of 0.97. The readability test results were obtained with an average readability percentage of 96% in the very good category and without revision. The effectiveness of the worksheets developed to improve science process skills obtained an N-gain of 0.71 in the high category. This means that PhET simulation integrated inquiry-based worksheets are feasible, practical, and effective for science learning to improve science process skills
Utilization of Banana Peel Waste as Anti-bacterial Organic Gloves with Latex Addition
Authors: Sari* Sri Adelila , Kabeakan Feri Yuni , Purba Elsa Christine , Vedha Renjana Sekar , Simarmata Yesi Angelia , Aldi Irfan , Hasibuan Hanisah
Published: November 2024

The increased use of synthetic gloves made from plastics such as nitrile and vinyl resulted in serious environmental problems due to plastic waste that was difficult to decompose. This study aimed to utilize banana peel waste for producing antibacterial organic gloves with the addition of latex. The manufacturing method involved mixing latex with ionol as an antioxidant, sulfur for vulcanization, and banana peel powder to add antibacterial properties. Tensile strength testing was conducted by varying the proportion of banana peel and chemical treatment using NaOH and NH4OH solutions. The results showed that increasing the proportion of banana peel led to a decrease in tensile strength and elongation of the material, from 22.5 MPa and 550% at a 10% banana peel ratio to 16.0 MPa and 480% at a 40% ratio. Treatment with NaOH resulted in a greater reduction than NH4OH. This study demonstrated that banana peels had potential as an environmentally friendly additive for the manufacture of antibacterial organic gloves. To improve its effectiveness, it was recommended that future research focus on optimizing the proportion of ingredients, developing the production process, and evaluating costs to achieve an optimal balance between quality, durability, and production efficiency
COORDINATES OF FOOD WASTE
Authors:   Bucharest University of Economic Studies, Romania, ION Raluca Andreea , LADARU Georgiana Raluca ,   Bucharest University of Economic Studies, Romania, PETRE Ionut Laurentiu ,   Bucharest University of Economic Studies, Romania, TRICA Carmen Lenuta ,   Bucharest University of Economic Studies, Romania
Published: November 2024

Studying food waste is crucial to achieving sustainability goals and ensuring global food security. A thorough understanding of food waste issues and the development of effective solutions requires detailed research and analysis. Through food wastage studies, effective strategies and policies can be developed to help reduce this major problem and support a more equitable and sustainable food system. Studying the factors causing food waste and its social, economic, environmental and nutritional implications helps stakeholders to better understanding this global issue and to identify solutions for its reduction.
FARM CARBON FOOTPRINT – ASSESSMENT METHODS
Authors:   Bucharest University of Economic Studies, AGRIDATA – Center for Research, Innovation, Extension and Technological Transfer, PĂTĂRLĂGEANU Simona Roxana , DINU Mihai ,   Bucharest University of Economic Studies, AGRIDATA – Center for Research, Innovation, Extension and Technological Transfer, PETRESCU Irina Elena ,   Bucharest University of Economic Studies, AGRIDATA – Center for Research, Innovation, Extension and Technological Transfer, DEACONU Elena-Mădălina ,   Bucharest University of Economic Studies, AGRIDATA – Center for Research, Innovation, Extension and Technological Transfer, CONSTANTIN Marius ,   Bucharest University of Economic Studies, AGRIDATA – Center for Research, Innovation, Extension and Technological Transfer
Published: November 2024

Minimizing the negative environmental effects of agricultural practices has become a shared objective through initiatives like the 2030 Agenda for Sustainable Development and the European Green Deal. In this regard, this research aimed at complementing the literature with a comparative view on a selection of farm carbon footprint assessment methods. This research is positioned within the broader context of the global efforts aimed at achieving agri- environmental sustainability. Through the exploration of diverse farm carbon footprint assessment frameworks, this paper sheds novel insights onto the quantification techniques of agricultural greenhouse gas emissions. Findings can support policy recommendations based on the identified methodologies that can successfully capture the most influential variables on the agri-food sector's transition towards practices that uphold the principles of sustainability at societal, economic, and environmental dimensions. Research results argue for the potential of life cycle assessment techniques to capture key agricultural elements in the quantification of greenhouse gas emissions. Hence, implementing these techniques in farm carbon footprint assessment frameworks ensures their efficiency.
ENERGY DEPENDENCY IN THE EUROPEAN UNION AND ROMANIA
Authors:   Bucharest University of Economic Studies, Romania, TORÓ Gyöngyi
Published: November 2024

This paper analyses the energy dependency rate in the European Union and Romania during 2010-2021. The quantitative research method is used to make a statistical analysis to establish the trend towards increasing or decreasing the energy dependency rate. Thus, analysing the official Eurostat data, we can see an increasing trend of the energy dependency rate between 2010 and 2019, both in the European Union and in Romania. And in 2020 is recorded the sharpest decrease in the entire period under analysis. Therefore, the hypothesis that the sharp decrease in the energy dependency rate is due to the negative effects of the COVID-19 pandemic is verified, which is fully confirmed.
Strategi Pengadaan Bahan Pustaka di Perpustakaan STMIK Triguna Dharma
Authors: Dani Suci Rahma , Sinamo Rizqi Aditya , Hasibuan Silva Lestari
Published: November 2024

Pengadaan bahan pustaka di perpustakaan mempunyai peranan yang sangat penting dalam meningkatkan kualitas perpustakaan. Tujuan penelitian ini ingin mengetahui bagaimana pengadaan koleksi Perpustakaan STMIK Triguna Dharma dan bagaimana cara mengelolanya. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi pustaka (library research). Teknik pengumpulan data dengan cara mencari dan mengumpulkan informasi yang relevan dari berbagai sumber seperti buku, jurnal, dan hasil riset yang pernah dilakukan. Hasil penelitian menunjukkan bahwa Perpustakaan STMIK Triguna Dharma merupakan salah satu perpustakaan perguruan tinggi yang mempunyai koleksi tentang manajemen dan teknologi informasi di Medan.  Perpustakan STMIK Triguna Dharma Medan mengolah, merawat, mengoleksi, dan mendayagunakan koleksi yang dimiliki untuk keperluan pemustaka. Untuk sumber pengadaan koleksi hanya dari mahasiswa, koleksi perpustakaan tersebut berupa buku, skripsi, dan laporan praktek. Library Procurement Strategy in the Library STMIK Triguna Dharma. Procuring library materials has a vital role in improving the quality of the library. This research aims to determine how to procure and manage STMIK Triguna Dharma Library collections. This research uses a qualitative approach with a library research method. Data collection techniques are used to search and collect relevant information from various sources such as books, journals, and research results. The results showed that STMIK Triguna Dharma Library is one of the university libraries with a management and information technology collection in Medan. STMIK Triguna Dharma Medan Library processes, maintains, collects, and utilizes the collections owned for users' needs. For the source of collection procurement only from students, the library collection is in the form of books, theses, and practice reports.
The role of virtual reality in improving the quality of professional training of natural science teachers
Authors: Truskavetska Iryna , Kyryienko Olena , Buslenko Lesia , Hrudynin Borys , Hurska Oksana
Published: November 2024

The use of information technologies, in particular virtual reality (VR), is becoming a topical issue in the professional training of natural science teachers. The study aims to assess the effectiveness of a professional development program that utilizes virtual reality as an educational tool to enhance the quality of training for natural science teachers. The obtained results testify to the positive impact of the VR use on various aspects of teachers’ professional training. The study found that the attitude towards technology improved significantly after the VR introduction (from 65% to 72%). The percentage of positive responses regarding the feasibility of using STEM (Science, Technology, Engineering and Mathematics) technologies in education increased by 25%. Student feedback emphasizes the importance of integrating new technologies into STEM education. Further research should examine the training needs of STEM teachers in different educational contexts, explore effective technology integration strategies, and assess their impact on student outcomes.
Assessment of Multifidelity Surrogate Approaches for Expedient Loads Prediction in High-Speed Flows
Authors: Korenyi-Both Tyler E. , McNamara Jack J. , Willems Jon , Reasor Daniel A.
Published: November 2024

Fast and accurate predictions about the flowfield surrounding a hypersonic flight vehicle are necessary for both early design phases and autonomous vehicle control. Data-driven model reduction presents an opportunity to harness the accuracy of high-fidelity techniques for expedient online application. Surrogate modeling is one approach that seeks to emulate the response of a system with evaluation times much faster than the data source. Multifidelity surrogate modeling seeks to reduce the amount of high-fidelity data needed for a sufficiently accurate online model. The objective of this paper is to assesses the tradeoffs between a kriging-based multifidelity model and a neural-network-based multifidelity model, applied to high-speed flow past a canonical flight geometry. All models studied in this work reproduce the results of the benchmark simulations with less than 100 training cases. The kriging models marginally outperform the neural-network-based models in accuracy, but requirements for training and storing the kriging models scale exponentially as the training data gets larger. Kriging models offer built-in uncertainty quantification and require significantly less decision making about hyperparameters and architecture choices. This study also indicates that the inclusion of data from classical engineering methods can improve the prediction accuracy of surrogate models at practically no cost.
Local-Variable-Based Transition Model for Hypersonic Flows Considering Wall Mass Injection
Authors: Fan Yuxiang , Zhao Rui , Shen Lihui , Liu Zaijie
Published: November 2024

Pyrolysis gas injection during the ablation process will affect the hypersonic boundary-layer transition. This paper proposes a three-equation [Formula: see text] transition model that considers wall mass injection. First, the boundary conditions of wall mass injection are established and verified. Second, based on analysis of the compressible boundary-layer solutions under wall mass injection, new transition correlations are developed. This allows an injection factor transport equation to be constructed using strictly local variables, and this equation is coupled with the [Formula: see text] transition model. Additionally, to model the wall mass injection effects in the fully turbulent zone, the wall boundary conditions for the specific turbulence dissipation rate are amended. The results of numerical simulations show that the transition onset locations and the changes in the heat transfer rate are reasonably consistent with experimental data.
Система кредитного менеджменту банку та її основні функції
Authors:   Національний університет «Чернігівська політехніка», Дубина Максим , Лобко Олег ,   Національний університет «Чернігівська політехніка»
Published: November 2024

У статті проведено дослідження теоретичних положень функціонування та розвитку системи кредитного менеджменту банку. Це реалізовано через вивчення сутності банківського менеджменту та конкретизації ролі кредитної діяльності в його розвитку. Також у статті виокремлено специфічні риси банківського менеджменту й проаналізовано основні його компоненти. Відповідно приділена увага обґрунтуванню доцільності використання системного підходу до дослідження кредитного менеджменту банку, поглибленню теоретичних положень функціонування системи такого менеджменту. У результаті розгляду підходів до конкретизації структури системи кредитного менеджменту банку виокремлено такі підходи її дослідження: організаційний, процесний, суб'єктний, структурно-продуктовий, стратегічний. У статті побудовано модель структури системи кредитного менеджменту банку та визначено особливості впливу такої системи на розвиток банківського менеджменту і її роль у забезпеченні фінансової стабільності комерційного банку.
Вплив цифрових технологій на стратегії розвитку фінансових посередників в Україні
Authors:   Національний університет «Чернігівська політехніка», Шишкіна Олена , Волошин Дмитро ,   Національний університет «Чернігівська політехніка», Ринжук Денис ,   Національний університет «Чернігівська політехніка»
Published: November 2024

У статті виявлено основні види стратегій, які можуть використовувати фінансові посередники, у тому числі стратегія цифрової трансформації, стратегія клієнтоорієнтованості, стратегія інновацій та розвитку продуктів, стратегія експансії та масштабування, стратегія злиття та поглинання, стратегія управління ризиками, стратегія сталого розвитку. Сформульовано сутність та зміст кожної з наведених стратегій, охарактеризовано їхні специфічні характеристики, переваги, недоліки й обмеження (умови) впровадження. Встановлено, що наведені стратегії надають фінансовим посередникам різноманітні цифрові інструменти для адаптації до мінливого ринкового середовища, але також вимагають ретельного планування та оцінки ризиків для їх ефективної реалізації. Доведено, що цифрові технології не лише підвищують ефективність та адаптивність фінансових посередників до змін, але й відкривають нові можливості для інноваційного зростання та сталого розвитку. Інтеграція зазначених технологій у бізнес-процеси фінансових установ дозволяє їм залишатися конкурентоспроможними та готовими до викликів сучасної цифрової економіки. Досліджено як FinTech, Big Data, блокчейн, штучний інтелект, машинне навчання та мобільні платформи, впливають на формування різних стратегій розвитку фінансових посередників.
Сучасні тенденції розвитку кредитного ринку України
Authors:   Національний університет «Чернігівська політехніка», Садчикова Ірина , Кальченко Ольга ,   Національний університет «Чернігівська політехніка», Панченко Олена ,   Національний університет «Чернігівська політехніка»
Published: November 2024

У статті розглянуто етапи історичного становлення кредитного ринку України, описано суб’єкти кредитного ринку , що дало змогу сформулювати поняття «кредитний ринок». Визначено основні функції забезпечення нормального функціонування кредитного ринку України. Проаналізовано структуру кредитного ринку та досліджено вплив інституційних факторів на його розвиток. Структуровано складові стратегічного розвитку кредитного ринку внаслідок впровадження інноваційних трансформацій. Показано та проаналізовано індекс фінансового стресу кредитного ринку України за 2013-2023 роки. Визначено заборгованість небанківських фінансових компаній, вивчено ринок нерухомості та іпотечного кредитування та визначено їхню роль у розвитку сучасного кредитного ринку. Проаналізовано боргове кредитне навантаження на домогосподарства. Структуровано показник кредитного ризику та виділена його роль у плануванні нових типів кредитних продуктів.
Теоретико-прикладні аспекти цифровізації сфери агробізнесу
Authors:   Чернівецький національний університет ім. Ю. Федьковича, Кифяк Вікторія
Published: November 2024

У статті поглиблено теоретико-прикладні положення цифровізації сфери аграрного бізнесу. Це реалізовано через детальний розгляд сутності цифровізації на основі аналізу існуючих наукових підходів до вивчення змісту цієї категорії, визначення її особливостей та ролі у розвитку економічних. систем. Також у статті значна увага приділена дослідженню впливу цифровізації на розвиток сучасного бізнесу, що дозволило конкретизувати сутність поняття «цифровізація аграрного бізнесу» та виокремити передумови впровадження інформаційно-комунікаційних технологіях в аграрній сфері. Також увага приділена визначенню і систематизації переваг і недоліків цифровізації аграрного бізнесу в сучасних умовах.
Unmasking Mania: A case report of risperidone-induced mania in a schizophrenia patient
Authors: Batra Shreya , Bhattacharya Sushmita
Published: November 2024

Risperidone is an atypical antipsychotic widely prescribed for the management of various psychiatric disorders, including schizophrenia. It is found to be most effective for treating the positive symptoms of psychosis and is also used for mania. Its mechanism of action is attributed to partial antagonism at serotonin and dopaminergic receptors. Through this mechanism, it has effectively treated the positive and negative symptoms of schizophrenia. However, there are few cases reported of risperidone-induced hypomania, a possible mechanism of this side effect is attributed to the partial agonistic action at the 5-HT2A receptors, by some authors. This case report presents the unique occurrence of manic symptoms due to risperidone in a 31-year-old male diagnosed with schizophrenia.
ТОКСИЧЕСКИЕ ЭФФЕКТЫ ХИМИОТЕРАПИИ НА ОРГАН ЗРЕНИЯ ПРИ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЯХ: ОБЗОР ЛИТЕРАТУРЫ
Authors: Е. Муратов , Е. Изтлеуов , Р. Ирмекбаев , Н. Алдашева , С. Кожантаева , Ф. Жумагельдиева , M. Таушанова
Published: November 2024

Химиотерапия при лечении злокачественных новообразований может вызывать токсические эффекты на орган зрения, такие как ретинопатия, кератопатия и конъюнктивит. На основе анализа публикаций из баз данных PubMed, MEDLINE, Scopus и Web of Science, подчеркивается необходимость регулярного офтальмологического мониторинга и разработки методов профилактики и лечения глазных осложнений. Также выявлены перспективы для дальнейших исследований по улучшению стратегий управления этими побочными эффектами. Цель: Изучение токсических эффектов химиотерапии на орган зрения у пациентов со злокачественными новообразованиями. Методы: Для исследования был проведен комплексный поиск в базах данных PubMed, MEDLINE, Scopus и Web of Science с использованием ключевых слов, связанных с химиотерапией, токсическими эффектами на зрение и злокачественными новообразованиями. Это позволило охватить широкий спектр публикаций и обеспечить достоверность результатов. Результаты: Химиотерапевтические препараты, такие как цисплатин и паклитаксел, могут вызывать глазные осложнения, включая ретинопатию, кератит и дисфункцию слезных желез, ухудшая качество жизни пациентов с раком. Препараты, как метотрексат и 5-фторурацил, вызывают апоптоз клеток сетчатки, что снижает остроту зрения. Целевая терапия (ингибиторы EGFR и FGFR) также приводит к осложнениям, подчеркивая необходимость офтальмологического наблюдения.
SiCN Nanofibers Supported Gold Catalyst for the Selective Oxidation of Cyclic Alkenes
Authors: Pillai Saravana K T
Published: November 2024

A general synthetic procedure for mesostructured metal nanoparticles integrated SiCN supports with preferable morphology has been developed. The synthetic procedure consists of two steps including i) concerted block copolymerization, microphase separation, and cross-linking ii) pyrolysis at 1000°C under inert atmosphere. Hydroxyl terminated polyethylene and an inexpensive commercially available polymeric carbosilazane precursor were used as organic and inorganic ceramic precursor blocks, respectively. The linked hybrid block copolymer is structured using microphase separation in a non-polar solvent. The synthesis of metal nanoparticles supported SiCN catalysts with fibrous morphology was synthesized by the addition of aminopyridinato complexes during copolymerisation step. The synthesized Au@SiCN-Nanofibers catalysts were characterized by Thermo gravimetric analysis, transmission electron microscopy, and powder X-ray diffractometer techniques. The Au@SiCN is active in oxidation of higher alkenes in the presence of air/O2 as an oxidant. More interestingly, Au@SiCN is highly selective in the cyclicalkenes over linear alkenes. This selectivity accounts for the activation of molecular oxygen due to surface plasmon resonance effect of Au (111) plane of nanoparticles followed by the epoxidation cycloalkenes. Models of cyclicalkenes oxidation are conducted and analysed by using 1H NMR and GC-MS measurements.
Light-modulated self-assembly of synthetic nanotubes
Authors: Dizani Mahdi , Agarwal Siddharth , Osmanovic Dino , Franco Elisa
Published: November 2024

Artificial biomolecular polymers with the capacity to respond to stimuli are emerging as a key component to develop living materials and synthetic cells. Here, we demonstrate artificial DNA tubular nanostructures that form in response to light in a dose-dependent manner. These nanotubes assemble from programmable DNA tile motifs that are engineered to include a UV-responsive domain, so that UV irradiation activates nanotube self-assembly. We demonstrate that nanotube formation speed can be tuned by adjusting the UV dose. We then couple light-dependent activation of tiles with RNA transcription, making it possible to control nanotube formation via concurrent physical and biochemical stimuli. Finally, we illustrate how UV activation effectively controls nanotube assembly in confinement, as a rudimentary stimulus-responsive cytoskeletal system that can achieve various conformations in a minimal synthetic cell. This study contributes new tile designs that are immediately useful to build biomolecular scaffolds with controllable dynamics in response to multiple stimuli.
On the differences in trimethylaluminum infiltration into PMMA and PLA polymers for sequential infiltration synthesis: insights from experiment and first principles simulations
Authors: Perego Michele , Motta Alessia , Ronnby Karl , Yap Forest Tung Jie , Seguini Gabriele , Wiemer Claudia , Nolan Michael
Published: November 2024

Sequential infiltration synthesis (SIS) is a powerful approach for templated growth of solid materials such as oxides or metals that exploits the difference in interaction of a precursor molecule with a polymer or block copolymer. While there have been studies showing that infiltration of trimethyl-alumina (TMA) in polymers can be used to grow Al2O3 there are still many atomic level details of the SIS process that require more investigation, including the origin of the differences in infiltration of TMA into different polymers. In this paper, we investigated in detail the Infiltration of Al2O3 into poly (methyl methacrylate) (PMMA) and poly (lactic acid) (PLA) experimentally and theoretically. SIS was performed in a standard ALD reactor, operating at 70°C in quasi-static mode, using TMA and water as the metal and oxygen precursors, respectively. Operando spectroscopic ellipsometry and ex-situ x-ray photoelectron spectroscopy (XPS) evidenced that Al2O3 incorporation in PLA is significantly higher than in PMMA even if, in both cases, TMA incorporation occurs through the formation of an Al-O covalent bond at the C-O-C group. The extent of swelling of the polymers upon TMA infiltration is assessed and is clearly larger for TMA in PLA than in PMMA. First principles density functional theory (DFT) calculations highlighted that both polymers display swelling upon TMA infiltration, saturating with increasing TMA, consistent with operando ellipsometry observations. The DFT results also show the origin of the larger swelling in PLA compared to TMA. Changes in vibrational modes of carbonyl backbone groups in the polymers are used to demonstrate TMA-polymer interactions from both experiment and simulation. The differences in TMA infiltration and swelling arises from differences in the TMA-polymer C-O-C group interaction, which is more exothermic in PLA than in PMMA, in agreement with experimental results. The combination of experimental and theoretical studies herein reported provides a toolkit to disclose the complexities of SIS at the molecular level.
Urban–rural geographic distribution of Otorhinolaryngologist, Head and Neck surgeons in Aotearoa New Zealand
Authors: Napier Thomas , Waterhouse David
Published: November 2024

aim: We identified geographic distribution of Otorhinolaryngologist, Head and Neck surgeons in Aotearoa New Zealand. To identify the future workforce pipeline, we explored trainee intentions for specialist practice. method: A survey was distributed to all New Zealand Society of Otolaryngology, Head and Neck Surgery (NZSOHNS) members and all current New Zealand Otolaryngology, Head and Neck surgery trainees. Data were gathered on work location and patterns of work, including on-call commitments and full-time equivalent hours worked. Trainees were asked about future career plans. results: An 88% response rate was achieved encompassing Senior Medical Officers (SMOs) and trainees. A total of 64.8% (68) of respondents reported primarily working in a metropolitan hospital and 26.7% (28) reported working in a regional centre. Rates of internationally trained surgeons were significantly higher in regional centres compared to metropolitan hospitals (64.3% vs 32.4% p<0.05). Regional respondents had higher after hours on-call burden, a higher full-time equivalent (FTE) worked and higher average hours worked per week. Retirement intentions within the next 10 years were high in both groups (64% regional and 52.9% metropolitan—p<0.05). conclusions: The regional workforce in ORLHNS work longer hours, are older and are reliant on internationally trained surgeons. Current training of ORLHNS surgeons is unlikely to keep pace with expected retirements.
Per-oral endoscopic myotomy: a multi-centre New Zealand experience
Authors: Graddon Christopher , Cameron Rees , Weilert Frank , Ogra Ravinder , Lim Gary , Khan Imran , Pandey Ratna , Htoo Aung , Buddle Georgia , Wynne Alexander , Schauer Cameron
Published: November 2024

background and aims: Per-oral endoscopic myotomy (POEM) is an established treatment for achalasia. We aim to review outcomes of all POEM cases performed in New Zealand for achalasia. methods: A retrospective review of all POEM procedures performed in the five hospitals offering POEM between November 2015 and December 2022 was undertaken. The primary outcome was clinical success, defined as Eckardt score ≤3. Secondary outcomes included procedural complications. results: One hundred and sixty-six index and four redo POEM procedures were performed by seven clinicians. Ninety-six (58%) were male and mean age was 49.6 years (standard deviation [SD] 19.2 years). Eighty-three (50%) had a previous achalasia intervention. Median length of hospital stay was 1 day (interquartile range [IQR] 1–2 days). Median pre-POEM Eckardt score was 8 (IQR 6–9) and improved to 0 (IQR 0–2) at 6 months (p<0.001). Technical success was achieved in 164 (99%). Clinical success was achieved in 124 (93%) at 6 months and sustained to 12 months in 37/42 (88%) of these patients with follow-up data. Clinical success was achieved in 92% who underwent any prior intervention. There were five reported complications: tunnel leak (three), significant pain (one) and pneumothorax (one). One tunnel leak required thoracotomy for empyema debridement, all other complications were managed conservatively. Forty-seven (31%) reported symptomatic reflux after POEM. conclusions: This first review of all POEM procedures performed in New Zealand for achalasia demonstrates high 6-month clinical success and safety for the management of achalasia.
Access to gluten free foods for people with coeliac disease in New Zealand
Authors: Hall Sophie , Kenrick Kristin , Day Andrew , Vernon-Roberts Angharad
Published: November 2024

aim: A strict gluten-free (GF) diet is the current mainstay of treatment for coeliac disease (CD). A limited range of GF foods are available on prescription for those with CD. GF foods purchased in shops are typically more expensive than gluten-containing equivalents. This study sought to understand how New Zealanders with CD obtain GF products and the changes associated with this. method: Coeliac New Zealand members was asked to complete an anonymous electronic survey in June 2023. results: Although 24% of the 522 respondents had accessed GF foods on prescription in the past, only 2% currently used the service. One-third of the respondents were unaware of the service. Cost and limited product range were the key reasons for not accessing prescriptions. Most non-prescription GF foods were purchased from a supermarket, with 54% spending over $50 per week on GF foods. Most respondents (90%) would prefer a discount card to purchase GF products. Preferences regarding the prescription service would be to collect products from a local shop (84%) or a pharmacy (42%). conclusion: This study indicates a very low uptake of GF products on prescription, with awareness, cost, product range and convenience limiting use of the service. Most respondents would prefer financial support for discounted GF products.
Comparison of Short-Term Clinical Effects of Minimally Invasive Anterior Talofibular Ligament Reconstruction versus Suture Anchor Repair for Chronic Lateral Ankle Instability
Authors: Zou Zhi , Zou Lin , Xu Chuntao , Jiang Zehui
Published: November 2024

Objective: To compare the short-term clinical effects of minimally invasive anterior talofibular ligament (ATFL) reconstruction versus suture anchor repair in patients with chronic lateral ankle instability. Methods: A retrospective analysis was conducted on 68 patients at the 960th Hospital of the Chinese People’s Liberation Army Joint Logistics Support Force between January 2022 and June 2023, patients were divided into two groups based on surgical procedure: Group A (ATFL reconstruction, 35 cases) and Group B (suture anchor repair, 33 cases). Follow-up ranged from 1 to 12 months, assessing the American Orthopaedic Foot and Ankle Society (AOFAS) score, VAS pain score, Tegner activity score, and patient satisfaction, while noting any recurrence of ankle instability or complications such as numbness or infection. Results: In Group A, the AOFAS score improved from 74.46 ± 2.96 preoperatively to 90.91 ± 2.79 at final follow-up, Tegner score from 2.40 ± 0.50 to 5.69 ± 0.76, and VAS from 3.14 ± 0.85 to 1.60 ± 0.50; patient satisfaction was 8.31 ± 0.72. In Group B, AOFAS improved from 74.48 ± 2.29 to 90.55 ± 3.12, Tegner from 2.48 ± 0.51 to 5.76 ± 0.79, and VAS from 3.45 ± 0.83 to 1.73 ± 0.50, with patient satisfaction at 8.27 ± 0.63. No significant statistical difference was found between groups in any score (P > 0.05), with both groups showing significant postoperative improvement (P < 0.05) and no serious complications within 1-year follow-up. Conclusion: Both ATFL reconstruction and suture anchor repair yield favorable short-term outcomes in treating lateral ankle instability. Further research is needed to assess if anatomical reconstruction offers superior biomechanical benefits in scar healing over the suture anchor repair in long-term follow-up.