bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1-15 from Merkel Cell Polyomavirus Small T Antigen Activates Noncanonical NF-κB Signaling to Promote Tumorigenesis
Authors: Zhao Jiawei , Jia Yuemeng , Shen Shunli , Kim Jiwoong , Wang Xun , Lee Eunice , Brownell Isaac , Cho-Vega Jeong Hee , Lewis Cheryl , Homsi Jade , Sharma Rohit R. , Wang Richard C.
Published: April 2023

Figure S1. Protein sequence alignment of HPyV6, HPyV7 and MCPyV small T antigens. Figure S2. Expression of HPyV sT induces p53-dependent senescence in human fibroblasts. Figure S3. Proliferation of BJ fibroblasts with expression of HPyV sT. Figure S4. Analysis of RNA-Seq from HPyV6, HPyV7, and MCPyV sT expressing BJ fibroblasts. Figure S5. Time course and extended analysis of additional SASP gene expression in BJ cells after sT expression. Figure S6. MCPyV sT shRNA confirms role of sT in SASP gene expression. Figure S7. Impact of LSD motif of MCPyV sT on gene expression and proliferation. Figure S8. MCPyV st, but not HPyV6/7 sT, stabilizes and activates c-Myc in an LSD motif dependent manner. Figure S9. Chromatin remodeling signatures induced by MCPyV sT. Figure S10. Mechanism of ncNF-ÃŽÂºB and SASP induction by MCPyV sT. Figure S11. ncNF-ÃŽÂºB signaling is required for SASP and EZH2 expression and affects cell proliferation. Figure S12. PyV sT conditioned media is not sufficient for growth in low serum. Figure S13. ST expression in VP-MCC lines and tumors. Figure S14. Impact of ncNF-ÃŽÂºB inhibition on VP-MCC and VN-MCC. Figure S15. Summary Figure.
Figure S2 from Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression
Authors: Alzofon Nathaniel , Koc Katrina , Panwell Kristin , Pozdeyev Nikita , Marshall Carrie B. , Albuja-Cruz Maria , Raeburn Christopher D. , Nathanson Katherine L. , Cohen Debbie L. , Wierman Margaret E. , Kiseljak-Vassiliades Katja , Fishbein Lauren
Published: April 2023

MAML3 overexpression has no effect on proliferation or apoptotic signaling. SK-N-SH, QGP-1 and BON-1 transfected with FL or dEx1 MAML3 and showed A) no increase in proliferation by BrdU assay when grown in full serum media for 72 hours and B) no increase in total or cleaved PARP or Caspase 3 when grown in serum free media for 48 or 72 hours. No cleaved caspase 3 was seen at all. The % of cleaved PARP was calculated after normalizing to beta tubulin and no significant differences were found at either time point for any cell line. Experiment performed N=3 with representative blots shown. T-PARP= total PARP; C-PARP=cleaved PARP; T-Caspase 3=total Caspase 3; C-Caspase 3=cleaved Caspase 3
Supplemental Methods including references, Supplemental Table 1, and Supplemental Figures 1-5 from Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling
Authors: Dwyer Amy R. , Kerkvliet Carlos Perez , Krutilina Raisa I. , Playa Hilaire C. , Parke Deanna N. , Thomas Warner A. , Smeester Branden A. , Moriarity Branden S. , Seagroves Tiffany N. , Lange Carol A.
Published: April 2023

Table S1. Oligonucleotide sequences used in this study. Figure S1. Amino acid sequence used to generate PTK6 domain mutant models. Figure S2. Characterization of PTK6 genetically modified MDA-MB-231 TNBC cell lines. Figure S3. PTK6 silencing reduces tumor-sphere formation. Figure S4: Dose-dependent effects of CT04 or CH223191 on growth inhibition in MDA-MB-231 and cHCI-10 TNBC cells. Figure S5: GR and AHR expression alone are not predictive of patient outcome.
Figure S1 from Thyroid Hormone Receptor Beta Induces a Tumor-Suppressive Program in Anaplastic Thyroid Cancer
Authors: Bolf Eric L. , Gillis Noelle E. , Davidson Cole D. , Rodriguez Princess D. , Cozzens Lauren , Tomczak Jennifer A. , Frietze Seth , Carr Frances E.
Published: April 2023

Supplemental Figure 1: TRβ Repressed PI3K Signaling. A) Endogenous expression of TRβ is greater in KTC-2 cells than in SW1736. B-C) ATC cell lines were treated with T3 for up to 8 days to measure cell counts. D) Growth kinetics of KTC-2 cells were significantly altered by T3 treatment as determined by area under the curve (AUC). n=3, * p<0.05.
Supplementary Tables 1-4 from ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells
Authors: Singh Latika , Muise Eric S. , Bhattacharya Anannya , Grein Jeff , Javaid Sarah , Stivers Peter , Zhang Jun , Qu Yujie , Joyce-Shaikh Barbara , Loboda Andrey , Zhang Chunsheng , Meehl Michael , Chiang Derek Y. , Ranganath Sheila H. , Rosenzweig Michael , Brandish Philip E.
Published: April 2023

Table S1 - Antibodies used for flow cytometry-based assessment of binding of anti-ILT3 and anti-ILT4 antibody to human primary cells and SK-MEL-5-educated monocytic myeloid-derived suppressor cells.

Table S2 - Antibodies used for flow cytometry-based assessment of ILT3 expression on myeloid cells in SK-MEL-5 tumor-infiltrating lymphocytes.

Table S3 - Differential gene expression in SK-MEL-5 educated MDSCs treated with anti-ILT3 vs. isotype control using RNAseq.

Table S4 - Pantherdb.org analysis for GO term enrichment of the 623 signatures.
Supplementary Materials and Methods and Supplementary Figure Legends 1-7 from ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells
Authors: Singh Latika , Muise Eric S. , Bhattacharya Anannya , Grein Jeff , Javaid Sarah , Stivers Peter , Zhang Jun , Qu Yujie , Joyce-Shaikh Barbara , Loboda Andrey , Zhang Chunsheng , Meehl Michael , Chiang Derek Y. , Ranganath Sheila H. , Rosenzweig Michael , Brandish Philip E.
Published: April 2023

Figure S1A-C - Dot plots and histograms from flow cytometry analysis of SK-MEL-5-educated M-MDSCs and PBMCs cultured in medium alone.

Figure S1D - FACS result of cell surface staining of cytokine-induced M-MDSCs and PBMCs cultured in medium alone.

Figure S1E - Cell surface staining of monocytes cultured in the presence of M-CSF and IL4 and SK-MEL-5-educated M-MDSCs by staining with HLA-DR.

Figure S2 A-B - ILT3 is highly expressed on CD45+CD33+CD14+ myeloid cells in SK-MEL-5 tumor-infiltrating lymphocytes.

Figure S3 - Single-cell RNAseq (scRNAseq) of human immune cells in non-small cell lung cancer (NSCLC) public dataset.

Figure S4 - Association of LILRB4 expression with deconvoluted cell fractions for human tumor types in the TCGA database.

Figure S5 - Suppression of autologous CD8+ T cell proliferation by cytokine-induced M-MDSCs.

Figure S6 - CD33+ cells from PBMCs cultured in medium alone are not suppressive.

Figure S7 - Differentially expressed genes (DEG) between SK-MEL-5 educated M-MDSCs and monocytes.
Supplementary Table 2 from Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells
Authors: Wang Qinglin , Wu Hao , Hu Jian , Fu Haijuan , Qu Yanghui , Yang Yijun , Cai Kathy Q. , Efimov Andrey , Wu Minghua , Yen Tim , Wang Yuan , Yang Zeng-Jie
Published: April 2023

Supplementary Table 2
Supplementary Figure Legends 1-7 from Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells
Authors: Wang Qinglin , Wu Hao , Hu Jian , Fu Haijuan , Qu Yanghui , Yang Yijun , Cai Kathy Q. , Efimov Andrey , Wu Minghua , Yen Tim , Wang Yuan , Yang Zeng-Jie
Published: April 2023

Supplementary Figure Legends 1-7
Supplementary Table 2 from Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13
Authors: Baietti Maria Francesca , Zhao Peihua , Crowther Jonathan , Sewduth Raj Nayan , De Troyer Linde , Debiec-Rychter Maria , Sablina Anna A.
Published: April 2023

ccRCC karyotype
Supplementary Table 2 from RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1
Authors: Kim Laura C. , Rhee Christopher H. , Chen Jin
Published: April 2023

List of Antibodies
Supplementary Figure 1 from RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1
Authors: Kim Laura C. , Rhee Christopher H. , Chen Jin
Published: April 2023

Copy number analysis of TCGA NSCLC samples with RICTOR amplification
Supplementary Table 1 and Legend from Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model
Authors: El Meskini Rajaa , Atkinson Devon , Kulaga Alan , Abdelmaksoud Abdalla , Gumprecht Michelle , Pate Nathan , Hayes Susana , Oberst Michael , Kaplan Ian M. , Raber Patrick , Van Dyke Terry , Sharan Shyam K. , Hollingsworth Robert , Day Chi-Ping , Merlino Glenn , Weaver Ohler Zoë
Published: April 2023

Study mouse cohorts
Figure S2 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Authors: Park Yuri , Baik Seunghan , Ho Charles , Lin Chin-Yo , Chung Sang-Hyuk
Published: April 2023

IHC results for p16 and Mcm7.
Supplementary Data from Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer
Authors: Shimizu Aasa , Sawada Kenjiro , Kobayashi Masaki , Yamamoto Misa , Yagi Taro , Kinose Yasuto , Kodama Michiko , Hashimoto Kae , Kimura Tadashi
Published: April 2023

Supplementary Data from Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer
Table S1 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Top pathways enriched at baseline (N=45) and progression (N=28) during ingenuity pathway analysis (IPA, Qiagen). Selection criteria; top genes altered in >=40% of the cases.
Supplemental Table S4 from Genomic Landscape of Primary and Recurrent Anal Squamous Cell Carcinomas in Relation to HPV Integration, Copy-Number Variation, and DNA Damage Response Genes
Authors: Aldersley Jordan , Lorenz David R. , Mouw Kent W. , D'Andrea Alan D. , Gabuzda Dana
Published: April 2023

Supplemental Table S4. Functional ontology enrichment of genes within recurrent CNVs in all ASCC tumors, primary ASCC tumors, and recurrent or metastatic ASCC tumors
Supplemental Figures S1-S2 from Genomic Landscape of Primary and Recurrent Anal Squamous Cell Carcinomas in Relation to HPV Integration, Copy-Number Variation, and DNA Damage Response Genes
Authors: Aldersley Jordan , Lorenz David R. , Mouw Kent W. , D'Andrea Alan D. , Gabuzda Dana
Published: April 2023

Supplemental Figure S1. HPV-18 genome coverage in ASCC. Supplemental Figure S2. Copy number variation in 81 ASCCs.
Figure S5 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Visualization of reference vs. alternate alleles in baseline vs. progression CTCs DNA. All the COSMIC validated mutations uniquely detected in baseline and paired progression CTCs DNA was visualized in the IGV genome browser with sequence read depth coverage, shown as snapshot images.
Figure S2 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Copy number alterations validations in independent publically available clinical datasets. (A) and (B) illustrating the top CTCs DNA genomic alterations were independently validated in 1115 patients from 1154 metastatic prostate cancer biopsy tissue samples using the cBioPortal database.
Supplementary Figure from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers
Authors: Hu Zhengbo , Viswanathan Ramya , Cheng Hui , Chen Jianghong , Yang Xinping , Huynh Angel , Clavijo Paul , An Yi , Robbins Yvette , Silvin Christopher , Allen Clint , Ormanoglu Pinar , Martin Scott , Cornelius Shaleeka , Saleh Anthony , Chen Zhong , Van Waes Carter , Morgan Ethan L.
Published: April 2023

Supplementary Figure from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Authors: Kim Minjung , Vu Ngoc T. , Wang Xue , Bulut Gamze B. , Wang Min-Hsuan , Uram-Tuculescu Cora , Pillappa Raghavendra , Kim Sungjune , Chalfant Charles E.
Published: April 2023

Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Supplementary Figure from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers
Authors: Maxwell Pamela J. , McKechnie Melanie , Armstrong Christopher W. , Manley Judith M. , Ong Chee Wee , Worthington Jenny , Mills Ian G. , Longley Daniel B. , Quigley James P. , Zoubeidi Amina , de Bono Johann S. , Deryugina Elena , LaBonte Melissa J. , Waugh David J.J.
Published: April 2023

Supplementary Figure from Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers
Supplementary Data from O-GlcNAcylation of Blimp-1 in Lymphocytes Inhibits Its Transcriptional Function and Is Associated with Migration and Invasion of Breast Cancer Cells
Authors: Chen Yan-Fang , Shao Guang-Can , Li Jie , Yang An-Qi , Li Jing , Ye Xin-Shan
Published: April 2023

Supplementary Data from O-GlcNAcylation of Blimp-1 in Lymphocytes Inhibits Its Transcriptional Function and Is Associated with Migration and Invasion of Breast Cancer Cells
Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS
Authors: Rathore Moeez , Zhang Wei , Wright Michel'le , Bhattacharya Rajat , Fan Fan , Vaziri-Gohar Ali , Winter Jordan , Wang Zhenghe , Markowitz Sanford D. , Willis Joseph , Ellis Lee M. , Wang Rui
Published: April 2023

Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS
Supplementary Figures 1-6 from Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells
Authors: McBrearty Noreen , Cho Christina , Chen Jinyun , Zahedi Farima , Peck Amy R. , Radaelli Enrico , Assenmacher Charles-Antoine , Pavlak Clarice , Devine Anne , Yu Pengfei , Lu Zhen , Zhang Hongru , Li Jinyang , Pitarresi Jason R. , Astsaturov Igor , Cukierman Edna , Rustgi Anil K. , Stanger Ben Z. , Rui Hallgeir , Fuchs Serge Y.
Published: April 2023

S1. Frequency of Pan-IN lesion types in KC versus KCC mice.
S2. Re-expression of Ch25h in PDAC cell lines.
S3. Presence of exogenous lipids diminishes effect of Ch25h re-expression in PDAC.
S4. Re-expression of Ch25h does not affect Ras localization.
S5. CH25H decreases autophagic flux in PDAC cells.
S6. Ch25h slows PDAC tumor growth.
Supplementary Figure from Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer
Authors: Peng Jian , Ma Yiming , Zhao Xinhua , Yang Xu , Wang Hongying
Published: April 2023

Supplementary Figure from Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer
Supplementary Figure from A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
Authors: Yang Fan , Rodriguez-Blanco Jezabel , Long Jun , Swiderska-Syn Marzena , Wynn Daniel T. , Li Bin , Shen Chen , Nayak Anmada , Ban Yuguang , Sun Xiaodian , Suter Robert K. , McCrea Heather J. , Capobianco Anthony J. , Ayad Nagi G. , Robbins David J.
Published: April 2023

Supplementary Figure from A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
Supplementary Data from Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition
Authors: Rahman Masum , Olson Ian , Mansour Moustafa , Carlstrom Lucas P. , Sutiwisesak Rujapope , Saber Rehan , Rajani Karishma , Warrington Arthur E. , Howard Adam , Schroeder Mark , Chen Sisi , Decker Paul A. , Sananikone Eliot F. , Zhu Yi , Tchkonia Tamar , Parney Ian F. , Burma Sandeep , Brown Desmond , Rodriguez Moses , Sarkaria Jann N. , Kirkland James L. , Burns Terry C.
Published: April 2023

Supplementary Data from Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition
Supplementary Figure from Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer
Authors: Gao Xueliang , Wang Yubao , Ribeiro Caroline F. , Manokaran Cherubin , Chang Hyeyoun , Von Thanh , Rodrigues Silvia , Cizmecioglu Onur , Jia Shidong , Korpal Manav , Korn Joshua M. , Wang Zhigang , Schmit Fabienne , Jiang Lan , Pagliarini Raymond , Yang Yi , Sethi Isha , Signoretti Sabina , Yuan Guo-Cheng , Loda Massimo , Zhao Jean J. , Roberts Thomas M.
Published: April 2023

Supplementary Figure from Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer
Supplementary Figure from GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
Authors: Sun Wenxiang , Guo Jingtao , McClellan David , Poeschla Alexandra , Bareyan Diana , Casey Mattie J. , Cairns Bradley R. , Tantin Dean , Engel Michael E.
Published: April 2023

Supplementary Figure from GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia
Supplementary Figure from Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth
Authors: Alam Shamshad , Zunic Amanda , Venkat Swati , Feigin Michael E. , Atanassov Boyko S.
Published: April 2023

Supplementary Figure from Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth
Supplementary Figure from KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity
Authors: Xiao Jin-Fen , Kua Ley-Fang , Ding Ling-Wen , Sun Qiao-Yang , Myint Khine Nyein , Chia Xiu-Rong , Venkatachalam Nachiyappan , Loh Xinyi , Duex Jason E. , Neang Vanessa , Zhou Siqin , Li Ying , Yang Henry , Koeffler H. Phillip , Theodorescu Dan
Published: April 2023

Supplementary Figure from KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity
Supplementary Data from CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2
Authors: Wu Yanjie , Duan Yang , Li Xuanyuan , Zhao Ran , Lan Bei , Zhang Xingyan , Wang Xiaochen , Chen Hao , Feng Shengyun , Liu Zhenfeng , Cheng Yiming , Xi Lishan , Wang Yingmei , Xue Fengxia , Xuan Chenghao
Published: April 2023

Supplementary Data from CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2
Supplementary Materials, Supplementary Figures 1-5 from Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants
Authors: Pinto Emilia M. , Maxwell Kara N. , Halalsheh Hadeel , Phillips Aaron , Powers Jacquelyn , MacFarland Suzanne , Walsh Michael F. , Breen Kelsey , Formiga Maria N. , Kriwacki Richard , Nichols Kim E. , Mostafavi Roya , Wang Jinling , Clay Michael R. , Rodriguez-Galindo Carlos , Ribeiro Raul C. , Zambetti Gerard P.
Published: April 2023

S1. Proband pedigrees. S2. TP53 status as determined by Multiplex Ligation Probe Amplification for Saos-2 and H1299 cell lines. S3. TP53 altering splice variants in the (a) IARC database (b) PCGP database. (c) Total germline TP53 variants observed in IPACTR and COG studies Circles represent number of cases. S4. Chromatogram representing the constructs for the TP53 variants included in this study. S5. p53 Immunostaining of pediatric tumors associated with germline mutations at codon 125 and surrounding sequences.
Supplementary Tables 1-3 from A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1
Authors: Ge Ruixiang , Wang Chenci , Liu Jiangang , Jiang Haibo , Jiang Xiaochun , Liu Zhuohao
Published: April 2023

Table S1. Primer sequences for mRNA expression analysis.
Table S2. Sequences of shRNA.
Table S3. Antibodies for immunoblotting.
Supplementary Figure 1-6 from A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1
Authors: Ge Ruixiang , Wang Chenci , Liu Jiangang , Jiang Haibo , Jiang Xiaochun , Liu Zhuohao
Published: April 2023

S1. Full images of immunoblotting.
S2. NFIX knockdown has no effect on p53 and p21 expression.
S3. Knockdown of GINS1 by shRNAs in U87 cells.
S4. Knockdown of GINS1 represses proliferation of GL261 cells
S5. GINS1 rescues the delayed growth of NFIX-null GL261 tumor.
S6. NFIX directly up-regulated GINS1 gene by occupying its promoter
Supplementary Table 1 from Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Du Qiang , Liu Silvia , Dong Kun , Cui Xiao , Luo Jing , Geller David A.
Published: April 2023

Expression of iNOS and EMT markers in different cancers
Table S5 from Hypertension Promotes the Proliferation and Migration of ccRCC Cells by Downregulation of TIMP3 in Tumor Endothelial Cells through the miR-21–5p/TGFBR2/P38/EGR1 Axis
Authors: Wang Chenguang , Xu Haibo , Liao Xinhui , Wang Weiming , Wu Wanjun , Li Wujiao , Niu Liman , Li Zhichao , Li Aolin , Sun Yangyang , Huang Weiren , Song Fei
Published: April 2023

Transcription factors that could potentially bind to the promoter region of TIMP3 estimated by HOCOMOCO (A) and JASPAR2018 (B)
Supplementary Table S1 from BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification
Authors: Barnett Sarah E. , Kenyani Jenna , Tripari Martina , Butt Zohra , Grosman Rudi , Querques Francesca , Shaw Liam , Silva Luisa C. , Goate Zoe , Marciniak Stefan J. , Rassl Doris M. , Jackson Richard , Lian Lu-Yun , Szlosarek Peter W. , Sacco Joseph J. , Coulson Judy M.
Published: April 2023

STR profiling MPM cell lines
Supplementary Figures S1 to S16 from BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification
Authors: Barnett Sarah E. , Kenyani Jenna , Tripari Martina , Butt Zohra , Grosman Rudi , Querques Francesca , Shaw Liam , Silva Luisa C. , Goate Zoe , Marciniak Stefan J. , Rassl Doris M. , Jackson Richard , Lian Lu-Yun , Szlosarek Peter W. , Sacco Joseph J. , Coulson Judy M.
Published: April 2023

Fig. S1. SNP6.0 analysis of parental MeT5A-BAP1+/+ cells.Fig. S2. Expression of catalytically active BAP1 in parental MeT5A.Fig. S3. Characterisation of BAP1 expression in gene-edited MeT5A.Fig. S4. Whole genome sequencing of gene-edited MeT5A.Fig. S5. Proliferative profiles for gene-edited MeT5A.Fig. S6. Enriched GO terms in gene-edited MeT5A SILAC-MS.Fig. S7. Enriched KEGG pathways in gene-edited MeT5A SILAC-MS include EMT.Fig. S8. Metabolite responses to BAP1 mutation in isogenic MeT5A.Fig. S9. Immunoblotting for differentially expressed metabolic enzymes identified by SILAC-MS in isogenic MeT5A cell lines.Fig. S10. Characterisation of BAP1-status for MPM cell panel.Fig. S11. Evaluating correlation between BAP1 and selected metabolic enzymes in a panel of MPM cell lines and the TCGA MESO pan-cancer dataset.Fig. S12. Validation of ASS1 response to BAP1 alteration.Fig. S13. Improved prognosis for epithelioid MPM patients with loss of nBAP1 and increased expression of ASS1.Fig. S14. Relationship between BAP1 and ASS1 transcripts in the TCGA Pan-Cancer datasets for other cancer types.Fig. S15. The influence of BAP1-status on response to inhibition of purine metabolism.Fig. S16. The influence of BAP1-status on response to ASS1 inhibition.
Supplementary Table 2 from ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Authors: Bass Thomas E. , Fleenor Donald E. , Burrell Paige E. , Kastan Michael B.
Published: April 2023

Supplementary Table 2 - BioID ATM screen data
Supplementary Table 1 from ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Authors: Bass Thomas E. , Fleenor Donald E. , Burrell Paige E. , Kastan Michael B.
Published: April 2023

Supplementary Table 1 - pSTQ
Supplementary Information Figures 1-10, Videos 1-8 from Autocrine Fibronectin Inhibits Breast Cancer Metastasis
Authors: Shinde Aparna , Libring Sarah , Alpsoy Aktan , Abdullah Ammara , Schaber James A. , Solorio Luis , Wendt Michael K.
Published: April 2023

S1. Differential fluorescent labeling of epithelial and mesenchymal cells. S2. Ca1h cells are not metastatic. S3. Fibronectin coated polystyrene induces a partial epithelialmesenchymal transition. S4. Fibronectin is in a fibular form in patient tumors. S5. Fibrillar fibronectin induction of EMT is dependent on the expression of b1 integrin. S6. Fibrillar fibronectin induces a mesenchymal phenotype. S7. Depletion of b1 increases intracellular FN. S8. Intracellular FN colocalizes with the actin cytoskeleton. S9. Systemically dormant cells express intracellular FN. S10.Depletion of FN increases pulmonary tumor proliferation.
Perspectives on this Article from Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging
Authors: Roblyer Darren , Kurachi Cristina , Stepanek Vanda , Williams Michelle D. , El-Naggar Adel K. , Lee J. Jack , Gillenwater Ann M. , Richards-Kortum Rebecca
Published: April 2023

Perspectives on this Article from Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging
Supplementary Appendix 1 from Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Fedirko Veronika , Bostick Roberd M. , Flanders W. Dana , Long Qi , Shaukat Aasma , Rutherford Robin E. , Daniel Carrie R. , Cohen Vaunita , Dash Chiranjeev
Published: April 2023

Supplementary Appendix 1 from Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Perspective on this Article from Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Fedirko Veronika , Bostick Roberd M. , Flanders W. Dana , Long Qi , Shaukat Aasma , Rutherford Robin E. , Daniel Carrie R. , Cohen Vaunita , Dash Chiranjeev
Published: April 2023

Perspective on this Article from Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Supplementary Table 1 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Authors: Morey Kinney Shannon R. , Zhang Wa , Pascual Marien , Greally John M. , Gillard Bryan M. , Karasik Ellen , Foster Barbara A. , Karpf Adam R.
Published: April 2023

Supplementary Table 1 from Lack of Evidence for Green Tea Polyphenols as DNA Methylation Inhibitors in Murine Prostate
Finasteride and Prostate Cancer: New York Times Article from Estimating Rates of True High-Grade Disease in the Prostate Cancer Prevention Trial
Authors: Pinsky Paul , Parnes Howard , Ford Leslie
Published: April 2023

Finasteride and Prostate Cancer: New York Times Article from Estimating Rates of True High-Grade Disease in the Prostate Cancer Prevention Trial
Supplementary Figure 3 from Aerosolized 3-Bromopyruvate Inhibits Lung Tumorigenesis without Causing Liver Toxicity
Authors: Zhang Qi , Pan Jing , North Paula E. , Yang Shoua , Lubet Ronald A. , Wang Yian , You Ming
Published: April 2023

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Perspective from Pathologic Characteristics of Cancers Detected in the Prostate Cancer Prevention Trial: Implications for Prostate Cancer Detection and Chemoprevention
Authors: Lucia M. Scott , Darke Amy K. , Goodman Phyllis J. , La Rosa Francisco G. , Parnes Howard L. , Ford Leslie G. , Coltman Charles A. , Thompson Ian M.
Published: April 2023

Perspective from Pathologic Characteristics of Cancers Detected in the Prostate Cancer Prevention Trial: Implications for Prostate Cancer Detection and Chemoprevention
Supplementary Figure 2 from A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social Isolation
Authors: Williams J. Bradley , Pang Diana , Delgado Bertha , Kocherginsky Masha , Tretiakova Maria , Krausz Thomas , Pan Deng , He Jane , McClintock Martha K. , Conzen Suzanne D.
Published: April 2023

Supplementary Figure 2 from A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social Isolation
Related Article from Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?
Authors: Kensler Thomas W. , Groopman John D.
Published: April 2023

Related Article from Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?
Supplementary Figure Legend from Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3
Authors: Tyagi Alpna , Singh Rana P. , Ramasamy Kumaraguruparan , Raina Komal , Redente Elizabeth F. , Dwyer-Nield Lori D. , Radcliffe Richard A. , Malkinson Alvin M. , Agarwal Rajesh
Published: April 2023

Supplementary Figure Legend from Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3
Supplementary Figure 1 from Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3
Authors: Tyagi Alpna , Singh Rana P. , Ramasamy Kumaraguruparan , Raina Komal , Redente Elizabeth F. , Dwyer-Nield Lori D. , Radcliffe Richard A. , Malkinson Alvin M. , Agarwal Rajesh
Published: April 2023

Supplementary Figure 1 from Growth Inhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokines and Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3
Supplementary Methods, Figures 1-4 from Deregulation of XPC and CypA by Cyclosporin A: An Immunosuppression-Independent Mechanism of Skin Carcinogenesis
Authors: Han Weinong , Soltani Keyoumars , Ming Mei , He Yu-Ying
Published: April 2023

PDF file - 332K, Supplemental materials and methods 2. Fig. s1. CsA down-regulates PTEN levels in non-tumor skin and tumors from UVB-irradiated mice and skin from sham- irradiated mice by immunohistochemical analysis. 3. Fig. s2. Alteration of CypA expression by CsA and in skin cancers. 4. Fig. s3. CypA had no effect on XPC levels, AKT activation, or UVB-induced DNA damage repair. 5. Fig. s4. The Effect of CsA on ATF3 levels and the role of Calcineurin B1 (CnB1)
Supplementary Table 1, Methods from Gut-Derived Lipopolysaccharide Promotes T-Cell–Mediated Hepatitis in Mice through Toll-Like Receptor 4
Authors: Lin Yan , Yu Le-Xing , Yan He-Xin , Yang Wen , Tang Liang , Zhang Hui-Lu , Liu Qiong , Zou Shan-Shan , He Ya-Qin , Wang Chao , Wu Meng-Chao , Wang Hong-Yang
Published: April 2023

PDF file - 85K, Table S1 (Real-time PCR primer sequence) and supplementary experimental procedures
Perspective on This Article from Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
Authors: Liby Karen T. , Royce Darlene B. , Risingsong Renee , Williams Charlotte R. , Maitra Anirban , Hruban Ralph H. , Sporn Michael B.
Published: April 2023

Perspective on This Article from Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
Perspective on this Article from Multiple Aberrations of Chromosome 3p Detected in Oral Premalignant Lesions
Authors: Tsui Ivy F.L. , Rosin Miriam P. , Zhang Lewei , Ng Raymond T. , Lam Wan L.
Published: April 2023

Perspective on this Article from Multiple Aberrations of Chromosome 3p Detected in Oral Premalignant Lesions
Supplementary Figure 1 Legend from Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer
Authors: Ford Nikki A. , Rossi Emily L. , Barnett Kelsey , Yang Peiying , Bowers Laura W. , Hidaka Brandon H. , Kimler Bruce F. , Carlson Susan E. , Shureiqi Imad , deGraffenried Linda A. , Fabian Carol J. , Hursting Stephen D.
Published: April 2023

Supplemental Figure 1. EPA+DHA supplementation does not significantly alter serum levels of A.
Legend for Supplementary Figure S1 from CXCR4 Is a Novel Target of Cancer Chemopreventative Isothiocyanates in Prostate Cancer Cells
Authors: Sakao Kozue , Vyas Avani R. , Chinni Sreenivasa R. , Amjad Ali I. , Parikh Rahul , Singh Shivendra V.
Published: April 2023

Legend for Supplementary Figure S1
Supplementary Table 2 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Authors: Ichimura Norihisa , Shinjo Keiko , An Byonggu , Shimizu Yasuhiro , Yamao Kenji , Ohka Fumiharu , Katsushima Keisuke , Hatanaka Akira , Tojo Masayuki , Yamamoto Eiichiro , Suzuki Hiromu , Ueda Minoru , Kondo Yutaka
Published: April 2023

Supplementary Table 2. Primer sets for pyrosequencing methylation analysis, mutation analysis, and RT-PCR
Supplementary Figure 3 from Prevention of Chemically Induced Urinary Bladder Cancers by Naproxen: Protocols to Reduce Gastric Toxicity in Humans Do Not Alter Preventive Efficacy
Authors: Lubet Ronald A. , Scheiman James M. , Bode Ann , White Jonathan , Minasian Lori , Juliana M. Margaret , Boring Daniel L. , Steele Vernon E. , Grubbs Clinton J.
Published: April 2023

Naproxen Serum Levels in Animals Administered Naproxen i.g. (40 mg/Kg BW)
Supplementary Figure 1 A from Prevention of Chemically Induced Urinary Bladder Cancers by Naproxen: Protocols to Reduce Gastric Toxicity in Humans Do Not Alter Preventive Efficacy
Authors: Lubet Ronald A. , Scheiman James M. , Bode Ann , White Jonathan , Minasian Lori , Juliana M. Margaret , Boring Daniel L. , Steele Vernon E. , Grubbs Clinton J.
Published: April 2023

Effects on Final Tumor Weights of Intermittent Dosing Regimens of Naproxen Compared to Control
Supplementary Data from Genome-wide Association Analysis of Proinflammatory Cytokines and Gene–lifestyle Interaction for Invasive Breast Cancer Risk: The WHI dbGaP Study
Authors: Jung Su Yon , Scott Peter A. , Papp Jeanette C. , Sobel Eric M. , Pellegrini Matteo , Yu Herbert , Han Sihao , Zhang Zuo-Feng
Published: April 2023

Supplementary Figures S1 to S3 and Supplementary Tables S1 to S8
Supplementary Figure from COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes
Authors: Cecil Denise L. , Gad Ekram A. , Corulli Lauren R. , Drovetto Nicholas , Lubet Ronald A. , Disis Mary L.
Published: April 2023

Supplementary Figure from COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes
Press Conference from Functional Viability Profiles of Breast Cancer
Authors: Brough Rachel , Frankum Jessica R. , Sims David , Mackay Alan , Mendes-Pereira Ana M. , Bajrami Ilirjana , Costa-Cabral Sara , Rafiq Rumana , Ahmad Amar S. , Cerone Maria Antonietta , Natrajan Rachael , Sharpe Rachel , Shiu Kai-Keen , Wetterskog Daniel , Dedes Konstantine J. , Lambros Maryou B. , Rawjee Teeara , Linardopoulos Spiros , Reis-Filho Jorge S. , Turner Nicholas C. , Lord Christopher J. , Ashworth Alan
Published: April 2023

Press Conference from Functional Viability Profiles of Breast Cancer
Download Supplementary Movie File from Toward Molecular Imaging–Driven Drug Development in Oncology
Authors: de Vries Elisabeth G.E. , Munnink Thijs H. Oude , van Vugt Marcel A.T.M. , Nagengast Wouter B.
Published: April 2023

Format: .mp4; Size: 59 MB.

Description of Movie

 Many rapidly dividing tumor cells express or overexpress surface receptor molecules that can be targeted with antibodies. Tracers (for example, the radionuclide zirconium-89) can be attached to these antibodies and administered to patients. Once the antibody reaches the surface receptor on the tumor cell, it is internalized and digested in an endosome, releasing the tracer. Accumulation of the tracer in the tumor cells can then be visualized.

NOTE: There is no audio component associated with this video file.
Supplementary Tables 1-5 from Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification
Authors: Corno Daniela , Pala Mauro , Cominelli Manuela , Cipelletti Barbara , Leto Ketty , Croci Laura , Barili Valeria , Brandalise Federico , Melzi Raffaella , Di Gregorio Alessandra , Sergi Lucia Sergi , Politi Letterio Salvatore , Piemonti Lorenzo , Bulfone Alessandro , Rossi Paola , Rossi Ferdinando , Consalez Gian Giacomo , Poliani Pietro Luigi , Galli Rossella
Published: April 2023

PDF file - 134K, Table S1 A. Lineage-specific differentiation of region-specific clonally derived NSCs is summarized as frequency of neurons, astrocytes and oligodendrocytes. B. Electrophysiological characteristics of neurons derived from the differentiation of region-specific NSCs. C. Analysis of the engraftment of region-specific clonally derived NSCs after transplantation in the early postnatal mouse cerebellum. Table S2 - Statistical analysis of GSEA for gene signatures generated by DEGs up regulated in hindbrain (CB/IVv) or forebrain (SVZ) NSCs. Table S3 - Lineage-specific differentiation of clonally derived MB CSCs is summarized as frequency of neuron-, astrocyte- and oligodendrocyte-like cells. Table S4 - Statistical analysis of GSEA for gene signatures generated by DEGs up regulated in tumorigenic Ptch+/- p53-/- MB CSCs vs. hindbrain NSCs (MB1_EXCLUSIVE), in non-tumorigenic Ptch+/- p53+/+ MB CSCs vs. hindbrain NSCs (MB2_EXCLUSIVE), and commonly expressed in both tumorigenic and non-tumorigenic CSCs vs. hindbrain NSCs (MB1_MB2 COMMON). Table S5 - Expression of EBF proteins in a collection of 33 human MB specimens as determined by immunohistochemistry.
Supplementary List 1 from Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification
Authors: Corno Daniela , Pala Mauro , Cominelli Manuela , Cipelletti Barbara , Leto Ketty , Croci Laura , Barili Valeria , Brandalise Federico , Melzi Raffaella , Di Gregorio Alessandra , Sergi Lucia Sergi , Politi Letterio Salvatore , Piemonti Lorenzo , Bulfone Alessandro , Rossi Paola , Rossi Ferdinando , Consalez Gian Giacomo , Poliani Pietro Luigi , Galli Rossella
Published: April 2023

PDF file - 135K, List of the top-ranking genes included in the two NSC-associated gene signatures List S2 - List of the top-ranking genes included in the three different CSC-associated gene signatures
Supplementary Figure 7 from Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification
Authors: Corno Daniela , Pala Mauro , Cominelli Manuela , Cipelletti Barbara , Leto Ketty , Croci Laura , Barili Valeria , Brandalise Federico , Melzi Raffaella , Di Gregorio Alessandra , Sergi Lucia Sergi , Politi Letterio Salvatore , Piemonti Lorenzo , Bulfone Alessandro , Rossi Paola , Rossi Ferdinando , Consalez Gian Giacomo , Poliani Pietro Luigi , Galli Rossella
Published: April 2023

PDF file - 155K, Enforced expression of Ebf3 in CB WM and SVZ NSCs results in premature neuronal differentiation, under proliferative and differentiative conditions
Supplementary Figure 1 from Identification of Luminal Breast Cancers That Establish a Tumor-Supportive Macroenvironment Defined by Proangiogenic Platelets and Bone Marrow–Derived Cells
Authors: Kuznetsov Hanna S. , Marsh Timothy , Markens Beth A. , Castaño Zafira , Greene-Colozzi April , Hay Samantha A. , Brown Victoria E. , Richardson Andrea L. , Signoretti Sabina , Battinelli Elisabeth M. , McAllister Sandra S.
Published: April 2023

PDF file - 287K, Characterization of responding tumors in LBC and TNBC systemic environments suggests different mechanisms of instigation
Supplementary Table S2 from Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1
Authors: Laine Anni , Sihto Harri , Come Christophe , Rosenfeldt Mathias T. , Zwolinska Aleksandra , Niemelä Minna , Khanna Anchit , Chan Edward K. , Kähäri Veli-Matti , Kellokumpu-Lehtinen Pirkko-Liisa , Sansom Owen J. , Evan Gerard I. , Junttila Melissa R. , Ryan Kevin M. , Marine Jean-Christophe , Joensuu Heikki , Westermarck Jukka
Published: April 2023

Supplementary Table S2 PDF file - 90K, Ingenuity transcription factor analysis of CIP2A depleted cells
Supplementary Figure Legends 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
Authors: Cheung Lydia W.T. , Hennessy Bryan T. , Li Jie , Yu Shuangxing , Myers Andrea P. , Djordjevic Bojana , Lu Yiling , Stemke-Hale Katherine , Dyer Mary D. , Zhang Fan , Ju Zhenlin , Cantley Lewis C. , Scherer Steven E. , Liang Han , Lu Karen H. , Broaddus Russell R. , Mills Gordon B.
Published: April 2023

Supplementary Figure Legends 1-6 from High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
Supplementary Figure Legends 1-9 from The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer
Authors: McKie Arthur B. , Vaughan Sebastian , Zanini Elisa , Okon Imoh S. , Louis Louay , de Sousa Camila , Greene Mark I. , Wang Qiang , Agarwal Roshan , Shaposhnikov Dmitry , Wong Joshua L. C. , Gungor Hatice , Janczar Szymon , El-Bahrawy Mona , Lam Eric W-F. , Chayen Naomi E. , Gabra Hani
Published: April 2023

PDF file - 76K
Supplementary Figure 3 from The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer
Authors: McKie Arthur B. , Vaughan Sebastian , Zanini Elisa , Okon Imoh S. , Louis Louay , de Sousa Camila , Greene Mark I. , Wang Qiang , Agarwal Roshan , Shaposhnikov Dmitry , Wong Joshua L. C. , Gungor Hatice , Janczar Szymon , El-Bahrawy Mona , Lam Eric W-F. , Chayen Naomi E. , Gabra Hani
Published: April 2023

PDF file - 113K
Figure S5 from Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma
Authors: Clozel Thomas , Yang ShaoNing , Elstrom Rebecca L. , Tam Wayne , Martin Peter , Kormaksson Matthias , Banerjee Samprit , Vasanthakumar Aparna , Culjkovic Biljana , Scott David W. , Wyman Sarah , Leser Micheal , Shaknovich Rita , Chadburn Amy , Tabbo Fabrizio , Godley Lucy A. , Gascoyne Randy D. , Borden Katherine L. , Inghirami Giorgio , Leonard John P. , Melnick Ari , Cerchietti Leandro
Published: April 2023

Figure S5 - PDF file 224K, Toxicity studies in mice
Supplementary Table S5 from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
Authors: Van Allen Eliezer M. , Wagle Nikhil , Sucker Antje , Treacy Daniel J. , Johannessen Cory M. , Goetz Eva M. , Place Chelsea S. , Taylor-Weiner Amaro , Whittaker Steven , Kryukov Gregory V. , Hodis Eran , Rosenberg Mara , McKenna Aaron , Cibulskis Kristian , Farlow Deborah , Zimmer Lisa , Hillen Uwe , Gutzmer Ralf , Goldinger Simone M. , Ugurel Selma , Gogas Helen J. , Egberts Friederike , Berking Carola , Trefzer Uwe , Loquai Carmen , Weide Benjamin , Hassel Jessica C. , Gabriel Stacey B. , Carter Scott L. , Getz Gad , Garraway Levi A. , Schadendorf Dirk
Published: April 2023

XLSX file 13K, Supplementary Table S5. PI3K pathway alterations. This table provides additional details on the PI3K pathway alterations observed in this cohort. Additional information regarding the time point, protein change, and appropriate reference are provided. Biopsy time point entries in gray denote situations where the tumor was unavailable for sequencing. Allelic fractions in bold denote situations where there is evidence for loss of the alternate allele between time points. (PMID = PubMed identification number). For activating or inactivating alterations, predicted function was derived by review of the published literature. The "likely" designation was reserved for alterations that occurred at the same amino acid residue as reported events but involved different changes at that site. For remaining missense mutations, "Probably Damaging" and "Possibly Damaging" designations were obtained from PolyPhen2 in silico predictions; alterations that met that criteria had PolyPhen2 scores between 0.9 and 1. Remaining nonsense mutations were considered "Probably Damaging"
Supplementary Table Legends from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
Authors: Van Allen Eliezer M. , Wagle Nikhil , Sucker Antje , Treacy Daniel J. , Johannessen Cory M. , Goetz Eva M. , Place Chelsea S. , Taylor-Weiner Amaro , Whittaker Steven , Kryukov Gregory V. , Hodis Eran , Rosenberg Mara , McKenna Aaron , Cibulskis Kristian , Farlow Deborah , Zimmer Lisa , Hillen Uwe , Gutzmer Ralf , Goldinger Simone M. , Ugurel Selma , Gogas Helen J. , Egberts Friederike , Berking Carola , Trefzer Uwe , Loquai Carmen , Weide Benjamin , Hassel Jessica C. , Gabriel Stacey B. , Carter Scott L. , Getz Gad , Garraway Levi A. , Schadendorf Dirk
Published: April 2023

PDF file 73K, This file contains legends for the five supplementary tables
Supplementary Figure from Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation
Authors: Xu Jin , Haigis Kevin M. , Firestone Ari J. , McNerney Megan E. , Li Qing , Davis Elizabeth , Chen Shann-Ching , Nakitandwe Joy , Downing James , Jacks Tyler , Le Beau Michelle M. , Shannon Kevin
Published: April 2023

Supplementary Figure 2 - PDF file 177K, Data showing survival and Hematologic Parameters of Nras heterozygous, hemizygous and homozygous mice
Supplementary Figure 1 from Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation
Authors: Xu Jin , Haigis Kevin M. , Firestone Ari J. , McNerney Megan E. , Li Qing , Davis Elizabeth , Chen Shann-Ching , Nakitandwe Joy , Downing James , Jacks Tyler , Le Beau Michelle M. , Shannon Kevin
Published: April 2023

Supplementary Figure 1 - PDF file 150K, Figure showing the generation and Functional Validation of a Conditional Mutant Nrasflox Allele
Supplementary Table S4 from The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer
Authors: Bishop Jennifer L. , Thaper Daksh , Vahid Sepideh , Davies Alastair , Ketola Kirsi , Kuruma Hidetoshi , Jama Randy , Nip Ka Mun , Angeles Arkhjamil , Johnson Fraser , Wyatt Alexander W. , Fazli Ladan , Gleave Martin E. , Lin Dong , Rubin Mark A. , Collins Colin C. , Wang Yuzhuo , Beltran Himisha , Zoubeidi Amina
Published: April 2023

Primer sequences.