bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengelompokan Produksi Daging Sapi Menurut Provinsi di Indonesia Tahun 2017-2022 dengan Menggunakan Metode K-Means
Authors: Ningsih Diah Restu
Published: January 2024

Demand for beef is a commodity that will continue to increase. In addition to nutritious milk and protein-rich meat, cows are very beneficial to humans. The consumption trend of Indonesians which continues to increase every year also shows this. However, adequate beef production, both in terms of quality and quantity, has not been sufficient to meet the increasing demand for beef. As a result, beef production has not been evenly distributed in all Indonesian provinces. This study aims to apply the K-Means Cluster method to group provinces and determine the characteristics of the clusters formed based on the level of beef production in Indonesia in 2017-2022. With this research, it can be input to the government and the people of Indonesia so that they can handle policies for regions that are included in the low cluster as an increase in the equity of beef production. This study clustered 3 groups. The results obtained were 10 provinces included in the low cluster, 21 provinces included in the medium cluster and 3 provinces included in the high cluster.
The Effect of Technology Utilization in Learning on Learning Motivation of Grade 11 PPLG Students of State Vocational Schools in Surakarta
Authors: Pratama Septian Nur Fajar , Basori Basori , Kurniasari Kurniasari
Published: January 2024

Education is a field that continues to develop along with technological advances. One important aspect of learning is student motivation because high motivation can improve learning outcomes. The utilization of information technology is very relevant, especially in State Vocational Schools in Surakarta which focus on the field of software and game development. Learning activities and the relevance of the material are the two key aspects that affect students' motivation. High meaningfulness of subject matter can encourage students to learn because students feel that the material studied is relevant to their lives. Interesting and fun learning activities can also increase student motivation to learn. Information technology can be a powerful tool to increase student motivation. To help kids study more efficiently and reach their full potential, specially created technology may be adapted to each student's needs and skills. In this study, grade XI students at State Vocational Schools in Surakarta will have their motivation to learn about the impact of using information technology in the classroom examined. This research uses qualitative methods to explore this. Through qualitative data analysis with interview and observation methods, it is expected to find a comprehensive picture of the extent of the influence of information technology utilization on learning motivation.
Flipped Book Based E-Module Interactive to Develop Meat Processing Technology Learning Media
Authors: Cakrawati Dewi - , Fitri Dewi - , Rahayu Dwi Lestari
Published: January 2024

The application of interesting learning media during the learning process is important to increase student enthusiasm which leads to increasing students’ cognitive results.  This study aimed to develop meat processing technology learning media using a flipped-book based e-module interactive. Meat processing technology was one of the subjects for students in class XI Agribusiness vocational high school. The learning media was developed based on the research and development method by applying the ADDIE model that consists of five steps: Analysis, Design, Development, Implementation dan Evaluation. The learning media was validated by judgment experts namely computer teacher, language teacher, and subject-related teacher. The instruments used for validation were questionnaires with a Likert scale from 1-to 4.  Judgment expert validation showed the learning media was qualified based on content (95.45%), language (95.83%), and features (86.67%). Features of media had the lowest grade according to judgment experts since several improvements were needed namely repairing the media cover, changing the font color to brighter color, give different colors to the font to differentiate the menu in the e-module. The media was improved based on suggestions from judgment experts before being used as learning media for meat processing technology subjects.
Kolaborasi dan Motivasi: Model Pembelajaran Berbasis Proyek sebagai Solusi untuk Meningkatkan Kompetensi Siswa di Sektor Industri
Authors: Fadhilah Roni Yudi , Efendi Agus , Pramono Sidik
Published: January 2024

Pembelajaran berbasis proyek (PjBL) merupakan salah satu model pembelajaran yang terbukti efektif dalam meningkatkan kompetensi siswa, khususnya dalam hal kolaborasi dan motivasi. PjBL mendorong siswa untuk bekerja sama dalam tim untuk memecahkan masalah dan menghasilkan produk yang nyata. Hal ini dapat meningkatkan keterampilan kolaborasi siswa, seperti kemampuan berkomunikasi, bekerja sama, dan memecahkan masalah secara kolaboratif. Selain itu, PjBL juga dapat meningkatkan motivasi siswa, karena siswa merasa lebih terlibat dalam pembelajaran dan memiliki tanggung jawab terhadap hasil proyeknya.
The Relationship between Students' Searning Interest and Learning Outcome
Authors: Wahdi Anang Saiful , Effendi Agus , Khurniawati Wiji
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh minat belajar terhadap hasil belajar siswa pada sekolah vokasi jurusan pengembang perangkat lunak & gim di salah satu sekolah kejuruan daerah Surakarta. Metode yang digunakan dalam penelitian ini adalah metode survei dengan pendekatan kuantitatif-kualitatif. 

 
Spinal Epidural Tuberculoma with Adjacent Vertebral Fracture
Authors: Kageshima Koutaro , Nagai Sota , Kawabata Soya , Ito Kei , Takeda Hiroki , Ikeda Daiki , Kaneko Shinjiro , Fujita Nobuyuki
Published: January 2024

Case:

An 85-year-old woman was transported to our institution due to difficulty in walking. Preoperative imaging showed spinal cord lesions indicative of spinal cord tumor at the T7-8 level, accompanied by T8 vertebral fracture. Intraoperatively, the spinal lesion was suspected to be an epidural abscess; therefore, the capsule was resected, and the abscess was drained. We added pedicle screw fixation at the T6-10 level. Postoperatively, the spinal cord lesion was definitively diagnosed as spinal epidural tuberculoma.

Conclusion:

Spinal epidural tuberculomas should be considered in the treatment of spinal cord lesions causing paralysis attributed to spinal cord compression.
Plan de negocios de snack de pitahaya deshidratada
Authors:   , Gutierrez Mantilla Rosila , Rojas Rojas Melissa Lizeth , Ricalde Gonzales Meri Luz , Tintaya Quispe Shary , Zuñiga Ugarte Luisa Anayka
Published: January 2024

El trabajo de investigación tiene como finalidad idear un plan de negocio, basado en introducir al mercado local snacks de pitahaya deshidratada por ser una fruta con alto valor nutricional, el principal objetivo es brindar una alternativa de consumo natural de snacks contribuyendo con el cuidado y la salud del consumidor quienes llevan un estilo de vida fatigoso. Como herramientas de investigación se utilizó las encuestas, entrevistas personales y la recopilación de información de fuentes primarias para establecer los objetivos y estrategias de marketing con el fin de promocionar los snacks utilizando los diferentes medios digitales de publicidad. Finalmente, se detalla el aspecto operacional de la cadena de suministros y la comercialización de los snacks con pitahaya deshidratada, rigiéndonos con el cumplimiento en base a los estándares de calidad en todos los procesos en base a la inocuidad para el consumo humano.
Plan de negocio para la exportación de licor de mango al mercado de Toronto – Canadá 2024
Authors:   , Cruz Alania Jhohann Isidro
Published: January 2024

El presente proyecto consiste en la producción de Licor a base de mango peruano que tiene como destino incursionar en el mercado de Toronto – Canadá, el cual se realiza por la empresa Agroindustrias del Norte Exportador (Agronortex SAC). Agronortex SAC viene hacer una empresa agroindustrial dedicada a la producción y exportación de Licores a base de mango peruano de calidad, licores elaborados con insumos naturales sin conservantes, velando así por la salud de los consumidores, el producto es de sabor exquisito para la degustación como aperitivo y después de cada comida, se caracteriza principalmente por ser una bebida antioxidante que regula el sistema digestivo del consumidor. La región Piura es considerada la primera región de productores y exportadores de mango en sus distintas variedades, posee una gran capacidad de producción por hectáreas es así que nuestra empresa establecerá su planta de producción en el distrito de Chulucanas, distrito en crecimiento productivo de mango en los últimos años. De la misma manera se da prioridad de contar con mano de obra directa de la misma zona de producción. Dentro de todo el análisis se detalla y estudia la situación actual del mercado de Toronto Canadá, cuestiones políticas, económicas, sociales y culturales que ayudan a determinar la aceptación del producto. Así mismo se hace un análisis interno de la compañía, se expone todo el plan de negocio y se busca la viabilidad y factibilidad del proyecto. El principal objetivo de la empresa es alcanzar una buena participación de mercado en el primer año, lograr un buen margen de utilidad y posterior a ello incursionar en nuevos mercados emergentes. En efecto, el resultado nos muestra un proyecto viable y factible con un VAN de S/1.511.677 soles y un TIR de 29%.
Resentimiento y resolución de problemas sociales en estudiantes adolescentes de nivel secundario en el distrito de Surcubamba VRAEM-2022
Authors:   , Lozano Olivar Kely Yasninda , Maravi Conopuma Anali Sandy
Published: January 2024

La principal fuente de motivación de este estudio fue encontrar la correlación entre la variable resentimiento y resolución de problemas sociales en adolescentes del nivel secundario de una institución educativa pública del distrito de Surcubamba VRAEM. El método de estudio es básico con alcance correlacional, diseño no experimental de corte transversal, el muestreo es no probabilístico en el cual la muestra estuvo constituida por 90 alumnos de tercero cuarto y quinto grado de secundaria de sexo femenino y masculino. Para medición de variables se utilizó los siguientes cuestionarios: Inventario de Actitudes Hacia la Vida (Escala de resentimiento), Permitió evaluar la variable independiente y la Escala de Habilidades de Resolución de Problemas Sociales (EHRPS) evaluó la variable dependiente. En cuanto a los hallazgos finales se demostró que existe una relación relevante entre la variable resentimiento y resolución de problemas sociales con valor de significancia menor P= 0.032 en la muestra investigada. Por otro lado; el nivel que predomina en la primera variable es la tendencia muy acentuada con un 93.3% y en la segunda variable el nivel que predomina es alto con un 97.8 %. En la dimensión de afrontamiento del problema el nivel que prima es alto con un 93.3% y en la dimensión orientación del problema el nivel que prevalece es alto con un 96.7%. Las conclusiones indican que los estudiantes presentan resentimiento, pero también poseen la capacidad para resolver problemas de índole social.
Asociación entre discapacidad visual y depresión en adultos mayores de 50 años de Perú: resultados de una encuesta poblacion
Authors:   , Jacinto Cabanillas Valeria Silvana
Published: January 2024

Objetivo: estimar la asociación entre el autorreporte de dificultad visual y los síntomas depresivos en adultos mayores de 50 años de Perú, durante el 2020. Materiales y método: se realizó un estudio transversal analítico de los datos secundarios de la Encuesta Demográfica y de Salud Familiar (ENDES) 2020. La variable independiente fue el autorreporte de dificultad visual y la variable dependiente fue la depresión medida con el Patient Health Questionnaire (PHQ-9). Se incluyeron posibles variables de confusión. Se utilizaron modelos crudos y ajustados de regresión logística ordinal y se estimaron odds ratios (OR) con sus intervalos de confianza al 95% (IC95%). Todos los resultados fueron ponderados de acuerdo al diseño muestral de la ENDES 2020. Resultados: incluimos los datos de 9033 adultos de 50 a más años. El 23,7% refirió que tenía dificultad visual y el 29,8% tenía síntomas depresivos. Las personas con dificultad visual tuvieron 2,28 veces la probabilidad de tener más síntomas depresivos en comparación con las personas sin dificultad visual (OR=2,28 IC95%: 1,95–2,68), ajustado por múltiples variables de confusión. Conclusiones: en el Perú, las personas de 50 a más años con dificultad visual tienen mayor probabilidad de tener más síntomas depresivos que sus pares sin dificultad visual.
The Effect of Mood on Shaping Belief and Recollection Following False Feedback
Authors: Li Chunlin , Otgaar Henry , Battista Fabiana , Muris Peter , Zhang Yikang
Published: January 2024

The current study examined how mood affects the impact of false feedback on belief and recollection. In a three-session experiment, participants first watched 40 neutral mini videos, which were accompanied by music to induce either a positive or negative mood, or no music. Following a recognition test, they received false feedback to reduce belief in the occurrence of the events displayed in some of the videos (Session 2). This was followed by an immediate memory test and a delayed memory assessment one week later (Session 3). The results revealed that participants in negative mood reported higher belief scores compared to those in positive moods, despite an overall decline in belief scores for all groups following the false feedback. Notably, individuals in negative moods exhibited less reduction in their belief scores after encountering challenges, thereby maintaining a higher accuracy in their testimonies. Over time, a reduction in the clarity of participants’ memory recall was observed, which correspondingly reduced their testimony accuracy. This study thus indicates that mood states play a role in shaping belief and memory recall under the influence of false feedback.
A universal strategy to induce oxidative stress-mediated cell death in biological systems
Authors: Möckl Leonhard , Almahayni Karim , Salvador Jana Bachir , Conti Riccardo , Widera Anna , Spiekermann Malte , Wehner Daniel , Grützmacher Hansjörg
Published: January 2024

Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we integrate the spatio-temporal precision of light delivery and the structural versatility of bisacylphosphane oxides (BAPOs), establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.
Do ethnic disparities exist in disease burden and healthcare utilization of male breast cancer: a 9-year cohort study of 18.19 million adults in China
Authors: Chen Jieying , Qiao Liying , Qi Meng , Zhang Yunjing , Yan Ying , Kang Weiwei , Zhou Huziwei , Yu Yuelin , Ke Yalei , Jiang Yuling , Rao Yingting , Xu Lu , He Guohua , Ren Jing , Yan Xue , Deng Siwei , Yang Xinyu , Song Yutong , Yang Yingzi , Wen Qiaorui , Han Jing , Wu Yiwei , Liu Guozhen , Wang Mingyuan , Zhang Xiaoyu , Xi Yunfeng , Wang Shengfeng
Published: January 2024

Background
As a rare disease, male breast cancer (MBC) is of increasing concern in China. Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear. We aim to measure disease burden and healthcare utilization by ethnicity among male breast cancer patients in China.
Methods
A retrospective cohort study was established during 2012–2021 based on Inner Mongolia Regional Health Information Platform. Disease burden including incidence, 5-year prevalence, mortality, survival rate, and medical cost were analyzed.
Results
Among 630 participants (mean [SD] age, 59.4 [13.1] years), age-standardized rates of incidence were 1.2 (95% CI: 0.4–2.1) per 100000. All-cause mortality was 50.8 per 1000 person-years (95% CI: 42.4–60.4) but breast cancer-specific mortality was 5.5 per 1000 person-years (95% CI: 3.0-9.3). Regarding ethnicity, Mongolian had a higher age-standardized 5-year prevalence rate than Han (3.2[95% CI: 2.5-4.0] vs 2.3[95% CI: 1.7-3.0], P = 0.016), but no significant differences existed in incidence rates, survival rates, and risk of all-cause and breast cancer-specific mortality. Patients residing in areas of lower GDP level were associated with increased breast-cancer specific mortality (HR, 22.5, [95% CI: 1.6–325.0]; P = 0.022).
Conclusions
This study revealed a moderate disease burden and relatively lower healthcare utilization for male breast cancer in Inner Mongolia, China. No significant ethnic disparities existed in disease burden and healthcare utilization. However, we still demanded for increasing attention to male breast cancer due to the crucial influence of economic factors on potential ethnic disparities.
Numerical Analysis of the Equilibrium Composition and Structural Features of Coal Combustion Products
Authors: Rah Shaon Md Tariqur , Hashan Antor Mahamudul , Rah Sharon Md Mahabubur
Published: January 2024

Coal is one of the primary working substances in the fossil-based power generation sector. The objective of this study is to investigate the combustion process of coal and its associated environmental consequences. We conduct numerical simulations to analyze the intricate processes associated with coal burning, considering both proximal and ultimate properties of various coal variants. The structural features in the fluidized bed, such as porosity and mass concentration in relation to pressure distribution, along with the limit value of pressure of a plume of dust at theoretical combustion temperature, are thoroughly studied. Various chemical reactions that occur during the burning of coal are considered to calculate the equilibrium composition of combustion products. We determine how the excess temperature and the amount of oxygen present significantly affect the equilibrium composition of combustion products. The study's findings provide valuable insights into the behavior of coal burning and its associated impacts. The enhancement of efficiency and environmental sustainability in coal-fired power plants can be achieved by a comprehensive study of the structural features and equilibrium composition of combustion byproducts. This work contributes to the field of energy research by offering a thorough numerical analysis of coal combustion products. The study findings can be utilized to improve combustion processes, reduce emissions, and enhance combustion efficiency. In order to enhance the comprehensiveness of our findings, we propose the utilization of the computational fluid dynamics (CFD) methodology.
Climate change may not reduce but redistribute global tuna abundance
Authors: Chen Xin Jun , Wang Jintao , Kang Bin , Zhang Fang , Zhu JiangFeng
Published: January 2024

Tuna, an invaluable source of animal protein for humanity, faces significant challenges due to climate-induced disturbances in its oceanic habitat. The resultant alterations in spatial distribution and abundance of tuna have perturbed the balance between supply and demand for tuna seafood on a global scale. Understanding the intricate interplay of potential positive and negative effects of climate change on tuna abundance is crucial for prudently ensuring sustainable resource utilization. Based on global longline and purse seine tuna fisheries datasets (albacore tuna, bigeye tuna, skipjack tuna, and yellowfin tuna), we used extreme gradient boosting to construct species distribution models to investigate the effects of abiotic and biotic environmental variabilities on the distribution and abundance for the four tunas during 1995–2019 worldwide and then predict the expected changes end-of‐the‐century under five shared socio-economic pathway (SSP119, SSP126, SSP245, SSP370, SSP585) emission scenarios. The model identify that the physical factors have more influence than biological factors, and similarly, the environmental variable from deep layer have more influence than those from surface on the tuna spatiotemporal distribution in the perspective of ocean-wide scale. The anticipated findings indicate that key areas of tuna abundance are poised to undergo shifts ranging from 1 to 8 degrees in diverse directions. Aggregate abundance is expected to fluctuate exceeding 60%, either decreasing or increasing relative to the levels observed in the year 2000S. These changes are contingent upon the specific tuna species and the oceanic context. In the context of medium-high intensity emission scenarios (specifically SSP379 and SSP585), the complexities of these situations are heightened. The continual manifestations of climate change underscore the imperative to proactively administer tuna resources, with a focus on open ocean ecosystem dynamics and global seafood security.
The Single-Dependence Sequential Testing Problem for the Living Kidney Donor Workup Process
Authors: Nielsen Joshua , El-Amine Hadi , Gentili Monica , Koizumi Naoru
Published: January 2024

The Sequential Testing Problem (STP) seeks to minimize the total expected cost of administering a series of tests which determine the quality of a system. When the probabilities of passing or failing a test are independent there exist many methods to solve the problem efficiently, but there is little research exploring the effect of dependency between tests. Motivated by the process of evaluating living kidney donors, we explore a variant of the STP which assumes that the probability of passing a given test is conditional upon passing the preceding test, and refer to this variant as the Single-Dependence Sequential Testing Problem (SDSTP). We present an optimization model to solve the SDSTP to optimality and simple - but effective methods to approximate the solution. Though we conjecture that the problem is NP-Complete, our experiments show that the model can be solved to optimality for many practical applications where the set of tests is small (say, less than 20), and our proposed algorithms also find near-optimal solutions in rapid time even for large numbers of tests.
Efficient Nonlinear Model Predictive and Active Disturbance Rejection Control for Trajectory Tracking of Unmanned Vehicles
Authors: Wang Hongwei , Liu Chenyu , Zhang Qingqing , Wang Liqiang
Published: January 2024

This article proposes an efficient trajectory tracking control strategy of unmanned vehicles. The method is based on nonlinear model predictive control (NMPC) and active disturbance reject control (ADRC). The designed control algorithm considers three challenges including nonlinear characteristics, multiple constraints and external disturbance. First, NMPC method is presented for the nonlinear vehicle model with multiple constraints. To relax inequality constraints and reduce the heavy calculation burden, the penalty term with the variable factor is added to the cost function, an improved continuous/generalized minimum residual method is proposed to solve NMPC online optimization problem. Then, an ADRC scheme is deigned to estimate the unknown disturbance via extended state observer, and compensate them by feedback control law in real time, the corresponding parameters are obtained by novel particle swarm optimization algorithm to further improve the control precision. It ensures the stability to a certain extent. Finally, the results indicate the designed algorithm can raise the calculation efficiency and meet the real-time requirements, and obviously increase the tracking accuracy and robustness performance.
An assessment of the implementation of HIV in the Workplace Policy, an anti- stigma and discrimination policy in Akwa Ibom State, Nigeria: A cross-sectional descriptive study
Authors: Idiong Helen M. , Ekanem Anyiekere M. , Nwanja Esther , Idiong Prince E. , Udofia Emilia A.
Published: January 2024

Background
Nigeria, like other countries in the world, has adopted policies to facilitate the implementation of HIV programs. One such policy, the HIV in the Workplace policy (HIV WPP), is an anti-stigma and discrimination policy that aims at protecting the rights of Persons living with HIV (PLHIV) in the workplace. Akwa Ibom State, one of the thirty-six states in Nigeria, adopted this policy in 2014. However, since its adoption, its implementation has not been assessed. This study aimed to assess the implementation of the HIV WPP in the state.
Methods
A cross-sectional study using a mixed methods approach was conducted for 591 consecutively recruited employees and 43 employers/ decision-makers across 23 organizations in Akwa Ibom State, Nigeria. The data were collected from October 2022 to February 2023. Seven criteria were used to assess policy implementation. They included policy availability, socio-economic and political contexts, stakeholders’ involvement, resource availability, leadership, operations and feedback. Scores above 70% were regarded as optimal policy implementation. Results were analyzed using SPSS 15.1 for quantitative and NVivo 10 for qualitative data.
Results
The study showed that 95% of organizations assessed had sub-optimal implementation (86.4% non-implementation and 9.1% poor implementation) of the AKS HIV WPP. Of the seven criteria used to assess policy implementation, the policy implementation failed on all points except one, socio-political environment. Prolonged engagement with donor agencies provided a good socio-political environment resulting in increased awareness of HIV in the state. However, only one (4.6%) organization, a private organization, fully implemented the policy on the seven domains of policy implementation. Most organizations had no HIV WPP policy (95.4%), no HIV committee (72.7%), inadequate resources (73.1%), and sub-optimal involvement of their leadership (59.2). There was a statistically significant association between the type of organization and the level of implementation of the AKS HIV WPP (p = 0.004).
Conclusion
The implementation of the AKS HIV WPP was poor due to many factors ranging from the unavailability of the document to lack of structures for its operationalization. It is recommended that the Akwa Ibom State Agency for the Control of AIDS (AKSACA) initiates and operationalizes the structures for its implementation through public-private collaboration. The availability of HIV-related organizational practices should provide a rationale for translating the state’s anti-stigma policy into organizational policies.
Hepatic Artery Stenosis Following Adult Liver Transplantation: Evaluation of Different Endovascular Treatment Approaches
Authors: Desai Sagar V. , Natarajan Balasubramani , Khanna Vinit , Brady Paul
Published: January 2024

Purpose:
To evaluate the efficacy and safety of hepatic artery interventions (HAI) versus extra-hepatic arterial interventions (EHAI) when managing clinically significant hepatic artery stenosis (HAS) after adult orthotopic liver transplantation.
Materials and Methods:
A single-center retrospective cohort analysis was conducted on liver transplant patients who underwent intervention for clinically significant HAS from September 2012 to September 2021. The HAI treatment arm included hepatic artery angioplasty and/or stent placement while the EHAI treatment arm comprised of non-hepatic visceral artery embolization. Primary outcomes included peri-procedural complications and 1-year liver-related deaths. Secondary outcomes included biliary ischemic events, longitudinal trends in liver enzymes and ultrasound parameters pre-and post-intervention.
Results:
The HAI arm included 21 procedures in 18 patients and the EHAI arm included 27 procedures in 22 patients. There were increased 1-year liver-related deaths (10% [2/21] vs 0% [0/27], p=0.10) and complications (29% [6/21] vs 4% [1/27], p=0.015) in the HAI group compared to the EHAI group. Both HAI and EHAI groups exhibited similar improvements in transaminitis including changes of ALT (-72 U/L vs -112.5 U/L, p=0.60) and AST (-58 U/L vs -48 U/L, p=0.56) at 1-month post-procedure. Both treatment arms demonstrated increases in post-procedural peak systolic velocity of the hepatic artery, while the HAI group also showed significant improvement in resistive indices following the intervention.
Conclusion:
Direct hepatic artery interventions remain the definitive treatment for clinically significant hepatic artery stenosis; however, non-hepatic visceral artery embolization can be considered a safe alternative intervention in cases of unfavorable hepatic anatomy.
11ip lymph node may play as N2 stage in right middle NSCLC
Authors: Han Xu , Zhang Wenjing , Jiang Wenjun
Published: January 2024

Background Right middle lobe NSCLC has a worse prognosis compared to other lobes possibly due to the lower number of lymph node dissections in surgery.So,we investigate the clinical significance of #11ip lymph node(LN) metastasis in right middle lobe NSCLC.Methods Symbolize the right lung #11 LN as superior 11(#11s), anterior 11(#11ia), and posterior 11(#11ip), based on their adjacency to the superior lobar bronchus, the middle lobar bronchus, and the region between right dorsal segmental bronchus and intermediate bronchus of right lung respectively in the view of single-port thoracoscopic surgery. The clinical data of mediastinal and #11 LN metastasis in 80 cases of right middle lobe NSCLC who were underwent surgical pulmonary resection from 2015–2022 were analyzed retrospectively and one case of #11ip LN metastasis retrogradely from #7 LN in bladder cancer was reported.Results None of 32 patients with pure ground-glass nodule (pGGN) were found to have lymph node metastasis (LNM). Out of the 48 patients with mixed ground-glass nodule (mGGN), no case with #11ip LNM was found in N1 cases(n = 6), but there was one case of #11ip LNM in N2 cases(n = 6).This tumor was in lateral segment and > 2 cm. #11ip LN resection with undifferentiated dorsal oblique fissure need more operative time than those with differentiated dorsal oblique fissure(149.32m to109.68m,p < 0.05) ,but postoperative drainage extubation time has no difference(5.22 days to 4 days,p = 0.116) and the postoperative drainage volume has no difference either (823.33ml to 607.14ml,p = 0.100). In addition, the survival period of N2 patient with #11ip LNM is 6 months.Conclusion To right middle lobe NSCLC with pGGN, #11ip LN dissection or biopsy is not necessary.Presenting as mGGN, #11ip LN should be dissected or biopsied particularly #4 or #7 LNM were found during surgery. #11ip LNM has a worse prognosis and may play as N2 stage in right middle lobe NSCLC.
The Impact of Utilizing Electronic Information Databases on Evidence-Based Practice Among Iranian Pharmacists: A Simulated-Based Survey.
Authors: Pourbala Hooman , Mohammadnezhad Ghader , Esmaily Hadi
Published: January 2024

Background: Evidence-based medicine (EBM) involves the conscious and careful utilization of the most reliable evidence available when making decisions regarding patient care. EBM can improve treatment plan success, patient compliance, rational use of medications, and healthcare costs.
Objectives: This study evaluated the knowledge, attitude, and practice of pharmacists regarding EBM utilization in community pharmacies.
Methods: A short questionnaire designed and validated to assess the knowledge and attitudes of community pharmacists. A simulated-patient method (SPM) was used to evaluate the practice one week after completing the questionnaire.
Results and Discussion: Within 284 pharmacy visits, the results of 200 pharmacists were collected entirely. The average knowledge score was 37.91 ± 15.4 out of 100. The pharmacists aged 24-29 demonstrated higher knowledge levels than older pharmacists (P=0.042). Furthermore, those who consult more than 30 prescriptions daily showcased a higher knowledge level (P=0.024). Additionally, it was found that pharmacists who utilized the UpToDate® clinical resource exhibited greater knowledge and practice in comparison to others (P<0.001). Most pharmacists had a positive attitude towards EBM and its implementation in the pharmacy (99.5%). The mean score of practice was 50.34 ± 21.35. A direct association was detected between knowledge and practice (r=0.73, P=0.023). There was no association between pharmacists' attitudes and their practice scores.
Conclusion: Most pharmacists agreed about the crucial need to incorporate EBM into pharmacy practices. Pharmacists with advanced knowledge of EBM and using UpToDate® showed better knowledge and practice.
Registration code: https://ethics.research.ac.ir/EthicsProposalView.php?id=152834
Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.
Authors: Yanagisawa Toshiki , Hayashi Koichiro , Tsuchiya Akira , Kishida Ryo , Ishikawa Kunio
Published: January 2024

Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granules from bone defects. Although covering the defect with a barrier membrane prevents granule emanation, this procedure is troublesome. To resolve these problems, we fabricated bioresorbable mesh cages (BMCs) in this study. Bone graft granules composed of carbonate apatite alone (Gr) and bioresorbable mesh cages (BMCs/Gr) introduced the bone graft granules and were implanted into the bone defect in the rabbit femur. Micro-computed tomography and histological analysis were conducted at 4 and 12 weeks after implantation. Osteoprogenitors in the bloodstream from the host bone passed through the pores of BMCs, penetrated the porous structure of graft granules, and might interact with individual granules. Then bone remodeling could progress actively and new bone was formed. The new bone formation was similar to the host bone at 12 weeks and there were minimal signs of local tissue inflammation. BMCs/Gr could reduce the risk of unwanted new bone formation occurring due to loss of granules from the bone defects compared with Gr because BMCs enclosed granules and prevent granules leakage from bone defects and BMCs could not induce unfavorable effects to forme new bone. Additionally, BMCs/Gr could keep specific amounts of granules assembled in one place, avoid displacement of granules to unintended locations, and carry easily. These results demonstrated that BMCs/Gr was effective in bone regeneration and improved clinical handling.
CD56 bright NK cell expansion correlated with EBV reactivation control post allogeneic hematopoietic stem cell transplantation
Authors: Juan Xie , Fan Zeying , Cao Xunhong , Shang Qian-nan , Liu Xuefei , Zhao Xiaosu , Chang Yingjun , Wang Yu , Xu Lanping , Zhang Xiaohui , Liu Kaiyan , Huang Xiaojun , Zhao Xiangyu
Published: January 2024

Natural killer (NK) cells are equipped with anti-Epstein-Barr virus (EBV) function, however，whether EBV infection will affect NK cells reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. To identify the characteristics of NK cells, we prospectively enrolled 22 patients with malignant hematological disease who occurred EBV reactivation or not post allo-HSCT. We found that that EBV infection resulted in the expansion of CD56bright and NKG2A+KIR- NK subsets ,and decreased the cytotoxicity function of NK cells. The percentages of NKG2A+KIR- NK cells were higher in patients who progressed into post-transplant lymphoproliferative disorder (PTLD) than EBV viremia patients, which also correlated with decreased proliferation and cytotoxic function. By screening the activation receptors of NK cells, we found the DNAM1+CD56bright NK cells is significantly increased after EBV stimulation. We found that DNAM1 is essential for EBV induced NK cells activation. After blocking DNAM1 on NK cells, the cytokine release against EBV-transformed lymphoblastoid cell lines(EBV-LCL) of CD56bright NK cells were significantly decreased. Anti-DNAM1 of NK cells diminished the clearance of EBV-LCL cells in EBV-related tumor mice model. A prospective cohort showed that old donor age was an independent risk factor for EBV infection. Rapid CD56bri expansion and high expression of DNAM-1 on CD56bri NK cells in response to EBV reactivation correlated with rapid EBV clearance post allo-HSCT in patients with younger donors. In summary, our data showed that high expression of DNAM-1 receptors on NK cell may participate protective CD56bri NK cells response to EBV infection after allo-HSCT.
The impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran: an interrupted time series analysis
Authors: Beiranvand Siavash , Behzadifar Meysam , Aryankhesal Aidin , Ehsanzadeh Seyed Jafar , Teli Banafshe Darvishi , Behzadifar Masoud
Published: January 2024

Background: The Covid-19 pandemic has posed unprecedented challenges to healthcare systems worldwide, affecting routine medical services, including for cancer patients. This study investigates the impact of the Covid-19 pandemic on outpatient visits for patients with cancer in Iran.
Methods: We interrupted time series analysis (ITSA) on data collected from electronic medical records. The ITSA methodology was employed to analyze monthly outpatient visits for patients with cancer data from March 2017 to January 2023 in Lorestan University of Medical Sciences.
Results: Following the announcement of Covid-19 in Iran, outpatient visits for patients with cancer decreased immediately, with a sharp mean of 247.08 visits per month. Subsequent waves in June 2020, September 2020, April 2021, July 2021, and January 2022 further affected outpatient visits. However, the initiation of Covid-19 vaccination, particularly for cancer patients, marked a positive turning point, leading to an increase in outpatient visits by 156.39 per month.
Conclusion: Our study provides critical insights into the dynamic relationship between the Covid-19 pandemic, patient behavior, and cancer care utilization. The observed decrease in outpatient visits underscores the multifaceted challenges faced by cancer patients during the pandemic, while the positive influence of vaccination signals a pathway towards recovery. Tailored interventions, informed by the experiences of Iran, can guide global efforts to optimize cancer care in the post-pandemic era. As healthcare systems adapt to ongoing challenges, understanding the complex interplay between public health crises and patient behavior is crucial for shaping resilient and patient-centric healthcare systems.
Effect of Anomeric and Exocyclic Hydroxymethyl Conformers on Intramolecular Hydrogen Bonds in Maltoside: A DFT Approach
Authors: Ramesh Rinaa , ManickamAchari Vijayan , Ahmadi Sara , Hashim Rauzah
Published: January 2024

Glycolipids with their unique structural diversity are used for various applications including food and medicine. For the optimal use of these lipids, it is vital to understand their behaviour at molecular level to design suitable lipids for use. Disaccharide glycolipids, namely n–dodecyl–α–D–maltoside (C12–α–Mal) and n–dodecyl–β–D–maltoside (C12–β–Mal) are chosen in this study since they can form a closed niosomes which can be used as drug delivery agent. A density functional theory (DFT) calculation on C12–α–Mal and C12–β–Mal was performed to optimize their geometry and calculate their electronic properties using Gaussian 09 software. The B3LYP level of theory with 6–31G and 6–31 + G (d,p) basis sets, and the polarizable continuum model (PCM) were used to determine the effects in explicit water condition. The AIM (Atoms in Molecule) was used to calculate the inter- and intra-molecular hydrogen bonding interactions. It is found that, the anomeric orientation of alkyl chain influences the exocyclic rotamer’s conformation and the bond lengths of hydroxyl groups in maltosides. A specific pair of conformers, gt_tg, shows the lowest energy for both the glycosides in the solvent phase. A visual analysis on the HOMO-LUMO orbital within the sugar rings elucidate the exocyclic group being the primary aspects that influences the glycosides behaviours. Among all the hydroxymethyls’ conformations the gt_tg pair of conformers can be found in both the glycolipids in the intramolecular hydrogen bond analysis using the AIM formalism, and this conformer can be considered as not affected by the anomeric orientation of the alkyl chain.
Analysis of influencing factors of assisted reproduction and assisted pregnancy outcome of infertile male based on Logistic Regression and Decision Tree Model
Authors: Wang Ke , Xu Yan , Zheng Jinxia , Qin Ningxin , Bai Jie , Sun Yan , Dong Yueyan , Li Zheyuan
Published: January 2024

Objective: To study the influencing factors of assisted pregnancy outcome in infertile men receiving assisted reproduction.
Design: From January 2023 to June 2023, a total of 1037 infertile men who planned to undergo IVF/ICSI-ET assisted pregnancy in the Department of Assisted Reproductive Medicine of the First Maternal and Infant Health Hospital Affiliated to Tongji University were selected as the research objects. Logistic regression and classification decision tree model were used to study the influencing factors of infertile men. Receiver operating characteristic (ROC) curves were used to evaluate the effects of the two prediction models.
Subjects: Infertile men undergoing assisted reproduction
Main Outcome Measures: Assisted pregnancy outcome of infertile men and construction of prediction model based on Logistic and decision tree
Results: The two models showed that the percentage of grade A sperm, the percentage of grade B sperm, the sperm DFI, whether smoking or drinking alcohol were the influencing factors of assisted pregnancy outcome of infertile men. Logistic regression model showed that age, education level, daily exercise time, spermatozoa survival rate, anxiety, depression and insomnia were the factors affecting the outcome of assisted pregnancy in infertile men. Among them, the percentage of grade A sperm is the main influencing factor of infertile men. Compared with the two models, the sensitivity and specificity of Logistic regression model were 91.3% and 88.4% respectively. The sensitivity and specificity of decision tree model are 80.6% and 64.2% respectively.
Conclusion: Both Logistic regression and decision tree model have certain classification and prediction value, among which Logistic regression model has better prediction ability than decision tree model. Clinical medical staff can make predictive plans according to the prediction results, improve sperm quality as soon as possible, relieve negative emotions, and improve the outcome of assisted pregnancy with assisted reproductive technology.
Heart Rate as a Predictor of Mortality in Heart Failure Patients at the Time of Discharge from the Intensive Care Unit
Authors: Hsiao Chia-Ying , Su Min-I , Chang Yu-Cheng , Lee Ying-Hsiang , Lin Po-Lin , Chiou Wei-Ru
Published: January 2024

Background
Heart rate serves as a critical prognostic factor in heart failure patients. We hypothesize that elevated heart rate in critically ill heart failure patients upon discharge from the intensive care unit (ICU) could be linked to adverse outcomes.
Methods
We implemented a retrospective cohort study using data collected between 2008 and 2019 from the Medical Information Mart for Intensive Care IV (MIMIC-IV version 2.0) database. From the 76,943 ICU stays, we enrolled 2,365 patients in this study.
Results
We observed correlations between in-hospital mortality and ICU discharge heart rate of 83.56 ± 15.81 bpm (survivors) vs. 93.84 ± 17.28 bpm (nonsurvivors, p < 0.001). Total mortality showed similar trends, with 83.67 ± 15.36 bpm (survivors) vs. 85.23 ± 17.25 bpm (nonsurvivors, p = 0.027), as did ICU readmissions at 83.55 ± 15.77 bpm (nonreadmitted) vs. 88.64 ± 17.49 bpm (readmitted, p < 0.001). Given multivariate analysis, the ICU discharge heart rate strongly predicted in-hospital mortality (OR 1.035 [95% CI 1.024‒1.046], p < 0.001), total mortality (OR 1.007 [95% CI 1.001‒1.014], p = 0.027) and ICU readmission (OR 1.015 [95% CI 1.007‒1.023], p < 0.001). Patients with an ICU discharge heart rate > 90 bpm demonstrated significantly higher in-hospital mortality (OR 2.986 [95% CI 2.066‒4.315], p < 0.001), total mortality (OR 1.341 [95% CI 1.083‒1.661], p = 0.007), and ICU readmission rates (OR 1.638 [95% CI 1.270‒2.114], p < 0.001).
Conclusion
The findings suggest that heart failure patients with an elevated heart rate (> 90 bpm) at ICU discharge are more likely to experience increased in-hospital mortality, total mortality, and ICU readmissions, indicating potential negative outcomes.
Linear Self-Acceptance and Nonlinear Social Comparison: Interacting Influences on Adolescent Depression
Authors: Ruan Qian-Nan , Zheng Yawen , Shen Guang-Hui , Wu Yu-Wei , Yan Wen-Jing , Huang Zi-Ye
Published: January 2024

Background
This research builds on the understanding that low self-acceptance is an important feature of adolescent depression, and that social comparison is a critical factor in self-concept formation during adolescence. However, there are gaps in our understanding of their interactive effects and the non-linear features between these factors in influencing adolescent depression.
Aim
The study attempts to test two main hypotheses: (1) increased levels of self-acceptance will correlate with reduced depressive symptoms and moderate the negative effects of social comparison on depression; and (2) the relationship between social comparison and depression will exhibit nonlinearity at different levels of self-acceptance.
Method
The study involved 243 adolescents undergoing psychiatric assessment, using dyadic polynomial regression analysis and response surface analysis. These methods were used to assess linearity or nonlinearity and interaction effects between self-acceptance, social comparison and depression.
Results
Significant findings included a strong negative correlation between self-acceptance and depression. Self-acceptance also showed a negative correlation with social comparison. Polynomial regression revealed a non-linear relationship between social comparison and depression, with moderate levels being beneficial but excessive levels being detrimental. The interaction effect suggested that high self-acceptance might buffer the negative effects of intense social comparison. Furthermore, response surface analysis revealed complex, non-linear interactions between these variables.
Conclusions
This study highlights the protective role of self-acceptance against depression and the complex, non-linear effects of social comparison. It highlights the importance of promoting self-acceptance and a balanced approach to social comparison in adolescent mental health interventions.
The Effects of Climate Change Atmospheric Tempreture, Rainfall Pattern and Land Use Malaria Incidence Rates: A Retrospective Trend Analysis Over a Ten-Year Period 2010–2020 in Luapula and Southern Province of Zambia
Authors: phiri joshua , Likwa
Published: January 2024

This study examines the impact of climate change on the incidence of malaria in Zambia. The study focused on variations in prevalence influenced by climatic and environmental factors. This study adopted a retrospective comparative analytical approach utilizing 157 case records from each province. The survey investigated temperature, seasonal variations, and land use activities. The findings revealed a fluctuating trend in rainfall from 2010 to 2020, with a significant association between malaria incidence and rainfall (p value=0.041). In 2019, southern provinces experienced the highest percentage of drought (64%), resulting in reduced malaria transmission due to unfavorable environmental conditions for mosquito larvae. Demographic data highlight an urban‒rural divide, with Luapula Province exhibiting a greater number of malaria cases among children under five years of age. These results emphasize the critical role of climate change and local factors in malaria transmission dynamics.