bluuebunny/crossref_metadata_2025 huggingface dataset:
Sella Turcica Morphology in Patients With Genetic Syndromes: Protocol for a Systematic Review (Preprint)
Authors: Roomaney Imaan Amina , Chetty Manogari
Published: November 2020

BACKGROUND

The sella turcica is an important anatomical reference used in orthodontics and the evaluation of craniofacial growth. Studies have found an association between variations in sella turcica morphology in patients with certain syndromes affecting the craniofacial complex. It is hypothesized that each related syndrome or pathological condition is associated with a specific pattern of malformation of the sella turcica.

OBJECTIVE

This study outlines the protocol for a systematic review that aims to determine if genetic syndromes involving the craniofacial complex are associated with abnormal radiographic sella turcica morphology and if there is a pattern of malformation that is consistent with each syndrome.

METHODS

An electronic database search was conducted using a planned search strategy to identify relevant studies. We included primary studies evaluating the morphology of the sella turcica based on imaging from a lateral view. Specifically, only studies with postnatal human participants with genetic syndromes involving the craniofacial complex were included in this review. We placed no restrictions on the language or time frame of these studies.
Based on the search findings, studies were further screened for relevance and eligibility by two independent reviewers. Data were extracted from the selected studies. We assessed the selected studies for risk of bias and quality by using risk of bias tools from the Joanna Briggs Institute. We will provide a narrative synthesis of our findings and a structured summary based on prespecified themes.

RESULTS

The protocol is registered with PROSPERO (#CRD42019148060) and approved by the University of Western Cape Biomedical Science Research Ethics Committee (BM205/3). The literature search was conducted in September 2019 and updated in July 2020. The study was completed in August 2020, and the findings will be published in an open-access journal.

CONCLUSIONS

The results of this systematic review are expected to provide a comprehensive list of morphological variations of the sella turcica, which will aid in the identification of syndromes associated with the craniofacial complex. We also expect to identify patterns of sella turcica morphology that highlight genotype-phenotype correlations, thus adding to the body of evidence relating to genetics and craniofacial malformations.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42019148060; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=148060

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/16633
Generating publicly available progress notes of authentic quality: A crowdsourcing-based approach (Preprint)
Authors: Kagawa Rina , Baba Yukino , Tsurushima Hideo
Published: November 2020

BACKGROUND

Sharing progress notes as a common social capital is essential in research and education, but the content of progress notes is sensitive and needs to be kept confidential. Publishing actual progress notes are difficult due to privacy concerns.

OBJECTIVE

This study aims to generate a large repository of pseudo-progress notes of authentic quality. We focused on two requirements for authentic quality: the validity and consistency of the data, from the perspective of medical practice, and the empirical and semantic characteristics of progress notes, such as shorthand styles used for reporting changes in a patient's physical status, long narrative sentences detailing patient anxiety, and interprofessional communications.

METHODS

We proposed a practical framework that consists of a simulation of the notes and evaluation of the simulated notes. The framework utilized two human cognitive traits: (1) the ability to use imitation to simulate objects with diverse characteristics without background knowledge and (2) the use of comparison as a strategy for deep thinking. This enabled crowd workers to generate a large number of progress notes. Our framework involved three steps. In step 1, crowd workers imitated actual progress notes decomposed into subject data (S), object data (O), and assessment and plan (A/P). These imitated texts were then shuffled and recomposed in S, O, and A/P in order to create simulated progress notes. In step 2, crowd workers identified the characteristics of actual progress notes based on comparisons between actual and dummy progress notes. These characteristics were clustered based on their similarities. Each cluster exhibited the empirical and semantic characteristics of the actual progress notes. Finally, in step 3, the texts from step 1 that exhibited the identified characteristics from step 2 were evaluated as quality-guaranteed progress notes that met the two requirements. All data were preprocessed to protect patient privacy.

RESULTS

Step 1: By recomposing the 700 imitated texts, 9,856 simulated progress notes were generated.
Step 2: 3,938 differences between actual progress notes and dummy progress notes were identified. After clustering, 166 characteristics were evaluated to be appropriate as empirical and semantic characteristics of the actual progress notes.
Step 3: 500 crowd workers demonstrated that 83.0% of the simulated progress notes satisfied at least one of the characteristics obtained in step 2. The crowd workers' artificially-reproduced progress notes were evaluated to determine the most realistic, based on four metrics: disease, morpheme, readability, and reality.

CONCLUSIONS

Our results demonstrated that crowd workers could generate and evaluate highly professional documents. We have made our large repository of high-quality crowdsourced progress notes publicly available, and we encourage their use in the development of medical education and research.
Not Race or Age but Their Interaction Predicts Pre-Adolescents’ Inhibitory Control
Authors: Assari Shervin , Akhlaghipour MD Golnoush
Published: November 2020

Background: African American pre-adolescents are at a higher risk of risky behaviors such as aggression, drug use, alcohol use, and subsequent poor outcomes compared to Caucasian pre-adolescents. All these high-risk behaviors are connected to low levels of Inhibitory Control (IC). Aim: We used the Adolescent Brain Cognitive Development (ABCD) data to compare Caucasian and African American pre-adolescents for the effect of age on pre-adolescents IC, a driver of high-risk behaviors. Methods: This cross-sectional analysis included 4,626 pre-adolescents between ages 9 and 10 from the ABCD study. Regression was used to analyze the data. The predictor variable was age measured in months. The main outcome was IC measured by a Stop-Signal Task (SST). Race was the effect modifier. Results: Overall, age was associated with IC. Race also showed a statistically significant interaction with age on pre-adolescents’ IC, indicating weaker effects of age on IC for African American than Caucasian pre-adolescents. Conclusion: Age-related changes in IC are more pronounced for Caucasian than African American pre-adolescents. To eliminate the racial gap in brain development between African American and Caucasian pre-adolescents, we should address structural and societal barriers that alter age-related development for racial minority pre-adolescents. Social and public policies, rather than health policies, are needed to address structural and societal barriers that hinder African American adolescents’ brain development. Interventions should add resources to the urban areas that many African American families live in so their children can have better age-related brain development. Such changes would be essential given IC in pre-adolescents is a predictor of a wide range of behaviors.
Maternal Opioid Abuse and Neonatal Abstinence Syndrome in the United States
Authors: Armstrong-Mensah Elizabeth , Woolcock Deja , Lee Christi , Diaz Morelia Torres
Published: November 2020

In the past decade, the United States has experienced an increase in deaths related to nonmedical and medical opioid overdose. This is due to a number of factors including an increase in recreational opioid use, and the over prescription of opioids for various conditions such as during pregnancy, injury, and illness. The over utilization of opioids during pregnancy in the United States has led to an increase in adverse neonatal birth outcomes including poor fetal growth, preterm birth, stillbirth, neonatal abstinence syndrome in neonates, and an increase in maternal mortality among mothers. These are dire consequences that should not be ignored. This paper discusses opioid abuse during pregnancy and its effects on neonates in the United States. It also discusses some challenges associated with the diagnosis of neonatal abstinence syndrome and provides recommendations for addressing the issue Additionally, it discusses what mothers can do to prevent neonatal abstinence syndrome.
Measuring mineralised tissue formation and resorption in a human 3D osteoblast-osteoclast co-culture model
Authors:   Orthopaedic Biomechanics, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands, Remmers S , Mayer D , Melke J , Ito K , Hofmann S
Published: November 2020

In vitro tissue engineered bone constructs have been developed, but models which mimic both formation and resorption in parallel are still lacking. To be used as a model for the bone remodeling process, the formation and resorption of mineralised tissue volume over time needs to be visualised, localised and quantified. The goal of this study was to develop a human 3D osteoblast-osteoclast co-culture in which 1) osteoblasts deposit mineralised matrix, 2) monocytes differentiate into resorbing osteoclasts, and 3) the formation and resorption of mineralised matrix could be quantified over time using micro-computed tomography (μCT). Mesenchymal stromal cells were seeded on silk fibroin scaffolds and differentiated towards osteoblasts to create mineralised constructs. Thereafter, monocytes were added and differentiated towards osteoclasts. The presence of osteoblasts and osteoclasts was confirmed using immunohistochemistry. Osteoclastic activity was confirmed by measuring the increased release of osteoclast marker tartrate resistant acid phosphatase (TRAP), suggesting that osteoclasts were actively resorbing mineralised tissue. Resorption pits were visualised using scanning electron microscopy. Mineralised matrix formation and resorption were quantified using μCT and subsequent scans were registered to visualise remodelling. Both formation and resorption occurred in parallel in the co-culture. The resorbed tissue volume exceeded the formed tissue volume after day 12. In conclusion, the current model was able to visualise, localise and quantify mineralised matrix formation and resorption. Such a model could be used to facilitate fundamental research on bone remodeling, facilitate drug testing and may have clinical implications in personalised medicine by allowing the use of patient cells.
4, 5-Dihydro-1H-Pyrazol-1-YL Derivatives as MAO-A Inhibitors with Antidepressant Profile: Insilico Design and Docking
Authors:   Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Kurnool–518218, Andhra Pradesh , India, Rajkumar T. , Kumar S.V. Suresh ,   Department of Pharmacognosy, Creative Educational Society’s College of Pharmacy, Kurnool–518218, Andhra Pradesh, India, Srinivasan N. ,   Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram–608002, India
Published: November 2020

Mono Amine Oxidase-A will be a key controller for typical brain activity. It is a flavoenzyme which debases amines, for example, dopamine, norepinephrine, and serotonin, by means of oxidative deamination. Main focal point of the existent research work is to design, docking and biological screening of novel Pyrazole derivatives on MAO-A as Antidepressants. In our present study we used software’s like ACD chemsketch and biological data bases like Protein Data Bank (PDB). ACD/Chem sketch (v 14.00) to draw molecules, reactions and schematic diagrams, calculate chemical properties and design professional reports and presentation. Also it can produce SMILES notations to structure. Open babel converts SMILES to PDB file for docking. Receptors like 2z5x, 2z5y, 2bxs 6fvz, 2bxr are downloaded from the Protein Data Bank (PDB). Docking studies were performed on docking Server. In order to explore their binding mode and selectivity behavior, molecular docking in the active site of MAO-A was carried out for these derivatives. Analysis of the docked poses of the compounds showed that they adopt similar conformations to the highly selective MAO-A inhibitor. The docking pose of compound with 2BXR was confirmed by molecular dynamics. By all these in silico data, it can be confirmed that all the designed compounds are having drug like nature and suitable as drug candidates and extremely promising which on further assessments may provoke medicine particles against Monoamine oxidase A. Especially, C, N can be considered as potent and can be used to treat depression and anxiety.
Fractional Order Two Temperature Generalized Thermoelasticity in a Symmetric Spherical Shell
Authors:   Mohsin Islam Department of Mathematics Vidyasagar Metropolitan College 39, Sankar Ghosh Lane, Kolkata–700006, India, Islam Mohsin
Published: November 2020

This paper deals with the determination of thermoelastic stresses, strain and conductive temperature in a spherically symmetric spherical shell in the context of the fractional order two temperature generalized thermoelasticity theory (2TT). The two temperature three-phase-lag thermoelastic model (2T3P) and two temperature Green Naghdi model III (2TGN-III) are combined into a unified formulation. There is no temperature at the outer boundary and thermal load is applied at the inner boundary. The basic equations have been written in the form of a vector-matrix differential equation in the Laplace- transform domain which is then solved by the state-space approach. The numerical inversion of the transform is carried out using Fourier-series expansion techniques. The physical quantities have been computed numerically and presented graphically. The effect of the fractional order parameter on the solutions has been studied and the comparisons among different thermoelastic models are made.
Experimental Investigation on Effects Accumulator Initial Pressure, Pump Displacement and Vehicle Speed on Regeneration Efficiency of the Hydraulic Regenerative Braking System
Authors:   Mechanical Engineering Department, Gujarat Technological University, Ahmedabad, Gujarat, Oza Nityam P. , Rathod Pravin P. ,   Gujarat Technological University, Ahmedabad, Gujarat
Published: November 2020

Recently researchers are focus on evaluation of hydraulic regenerative braking systems for improving fuel economy and reducing pollutant emissions. Present work is oriented to study effects of variation in vehicle speed at braking, accumulator initial pressure and pump displacement on regeneration efficiency of hydraulic regenerative braking system (HRBS) on the school van conveyance in Vadodara city. The results show that the HRBS regeneration efficiency improves between 1.7 to 10% with reduction in initial pressure from 110 to 90bar. Increase in pump displacement from 16 LPM to 23 LPM results in rise in regeneration efficiency of the HRBS between2.6 to 16.7%. While increasing initial speed at braking from 20 to 35 KMPH, regeneration efficiency of the HRBS system rises by 48%. This is the maximum rise in regeneration efficiency while varying the initial braking speed.
Optimasi nisbah natrium nitrat : urea dan konsentrasi nitrogen pada kultivasi Spirulina platensis untuk produksi protein dan pigmen fikosianin
Authors: KURNIAWATI Rizki , PRAHARYAWAN Swastika , TRI-PANJI .
Published: November 2020

The need of nitrogen (N) for the growth of Spirulina platensis and the production of protein and phycocyanin pigment is influenced by the type of source and the concentration of N contained in the growing media. Spirulina platensis can assimilate various N sources, including nitrate (NO3-) and urea. Urea is a cheap N source and easy to be obtained. Urea can also have a role as potential N source to support the growth and the metabolites production of cyanobacteria S. platensis. Partial substitution of N source (NO3‑) to urea in Zarrouk medium for S. platensis cultivation has not been conducted before. This study was aiming at determining the optimum ratio of NaNO3 : CO(NH2)2 and the optimum N concentration in the Zarrouk medium for protein and phycocyanin production by S. platensis. Response Surface Method (RSM)-one factor experimental design was employed in this study for determining the optimum N concentration at specific N concentration range and optimum ratio of N source that had been previously determined. The results demonstrated that the optimum ratio of NaNO3 : CO(NH2)2 for protein and phycocyanin production was 1:1. The optimum N concentration for protein and phycocyanin pigment production in S. platensis cultivation were 5.13 mmol L-1 and 4.94 mmol L-1 with the increament in about 51.95% and 25.16%, respectively, compared to the standar Zarrouk medium.Kebutuhan unsur nitrogen (N) untuk pertumbuhan Spirulina platensis serta produksi protein dan pigmen fikosianin dipengaruhi oleh jenis sumber dan konsentrasi N yang terkandung dalam media tumbuh. Spirulina platensis dapat mengasimilasi berbagai sumber N, termasuk nitrat (NO3-) dan urea. Urea merupakan sumber N yang murah dan mudah diperoleh. Urea juga dapat berperan sebagai sumber N potensial untuk mendukung pertumbuhan dan produksi metabolit pada sianobakteria S. platensis. Substitusi sebagian sumber N (NaNO3) oleh urea dalam media Zarrouk untuk kultivasi S. platensis belum banyak dilakukan sebelumnya. Penelitian ini bertujuan untuk menentukan nisbah NaNO3 : CO(NH2)2 dan konsentrasi N optimum yang diperlukan dalam media Zarrouk untuk produksi protein dan fikosianin oleh S. platensis. Desain eksperimen RSM-one factor digunakan dalam penentuan konsentrasi N optimum pada rentang konsentrasi N dan nisbah sumber N optimum yang telah ditentukan sebelumnya. Hasil penelitian menunjukkan bahwa nisbah NaNO3 : CO(NH2)2 optimum untuk meningkatkan kandungan protein dan pigmen fikosianin S. platensis adalah 1:1. Konsentrasi N optimum untuk produksi protein dan pigmen fikosianin pada kultivasi S. platensis ialah 5,13 mmol L-1 dan 4,94 mmol L-1 dengan peningkatan sebesar 51,95% dan 25,16%, secara berturut-turut, bila dibandingkan dengan saat dikultivasi menggunakan media Zarrouk standar.
Guerra y canibalismo en el valle del río Cauca en la época de la conquista española
Authors: Jaramillo E Luis Gonzalo
Published: November 2020

En el momento de la conquista los españoles informaron de una alta incidencia de la guerra y el canibalismo entre los grupos del Valle del Cauca. En este artículo se señala que uno de los principales problemas de las recientes interpretaciones de la guerra y el canibalismo es la suposición de que la incidencia de estas prácticas, tal y como las denuncian los españoles, refleja la situación real de los asuntos indígenas. Esta actitud no tiene en cuenta el impacto de la presencia española en términos de la creación de nuevas condiciones políticas, militares y sociales. Aunque se discuten ambos aspectos (guerra y canibalismo), el artículo se concentra en la guerra en la medida en que se relaciona con la organización social. Se propone el desarrollo de la investigación arqueológica de los patrones de asentamiento como una estrategia de investigación para descubrir hebras independientes de pruebas para promover una mejor comprensión de las condiciones sociopolíticas y económicas en las que operaba el sistema de guerra y canibalismo en la época prehispánica. Los grupos Anserma, Quimbaya y Arma se discuten desde esta perspectiva.
Lugares y redes. Las mediaciones de la cultura urbana
Authors: Agier Michel
Published: November 2020

La investigación sobre la importancia relativa aplicada a las zonas de una ciudad nos habla de las identidades urbanas; el estudio de las conexiones sociales nos habla de las culturas responsables del apego a los lugares urbanos y también de la reproducción o reinvención de los vínculos sociales en los entornos densos, abiertos y heterogéneos de las sociedades contemporáneas. El popular suburbio de Liberdade, en San Salvador de Bahía (Brasil), se toma como estudio de caso desde estos dos puntos de vista. Se trata de un suburbio negro proletario, densamente poblado y animado, acogedor y amenazador, conservador y -paradójicamente- con una fuerte tradición urbana: antigüedad, permanencia y estabilidad son otros conceptos asociados a él. El estudio trata de determinar qué lazos sociales son responsables del sentimiento de apego a este lugar por parte de sus habitantes; o, dicho de otro modo, cómo se crea la identidad social. Busca la fuente de las identidades ligadas a ciertas partes de la ciudad, que definen al individuo como persona, y utilizando el concepto de la red intenta determinar el tipo de cultura creada por el mundo de las relaciones urbanas.
“Just Look,” He Said
Authors: Alvord Ellsworth C.
Published: November 2020

Five personal examples are given illustrating the general principle that one can see if one looks or, conversely, that one cannot see anything that one believes not to exist. ( J Child Neurol 2006;21:247—249; DOI 10.2310/7010.2006.00042).
Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis
Authors: Henderson C. Beth , Filloux Francis M. , Alder Stephen C. , Lyon Joseph L. , Caplin Deirdre A.
Published: November 2020

The evidence base for the efficacy of the ketogenic diet was assessed among pediatric epileptic patients by application of a rigorous statistical meta-analysis. Nineteen studies from 392 abstracts met the inclusion criteria. The sample size was 1084 patients (mean age at initiation 5.78 ± 3.43 years). The pooled odds ratio, using a random effects model, of treatment success (> 50% seizure reduction) among patients staying on the diet relative to those discontinuing the diet was 2.25 (95% confidence interval = 1.69—2.98). The reasons for diet discontinuation included < 50% seizure reduction (47.0%), diet restrictiveness (16.4%), and incurrent illness or diet side effects (13.2%). The results indicate that children with generalized seizures and patients who respond with > 50% seizure reduction within 3 months tend to remain on the diet longer. Although no class I or II studies have been published regarding the efficacy of the ketogenic diet, this meta-analysis shows that current observational studies reporting on the therapeutic effect of the ketogenic diet contain valuable statistical data. Future observational studies should aim for long-term follow-up, patient dropout analysis, and improved seizure type characterization. ( J Child Neurol 2006;21:193—198; DOI 10.2310/7010.2006.00044).
Adolescents' Perception of Epilepsy Compared With Other Chronic Diseases: “Through a Teenager's Eyes”
Authors: Cheung Christina , Wirrell Elaine
Published: November 2020

Adolescent perception of physical and social impact of chronic illness was assessed to determine (1) if there is greater prejudice toward epilepsy than other chronic disease and (2) if adolescents with chronic disease have less prejudice toward similarly affected peers with all types of chronic disease or just their specific chronic disease. Cognitively normal teens aged 13 to 18 years without chronic disease ( n = 41) and with epilepsy ( n = 32), asthma ( n = 38), diabetes ( n = 21), and migraine ( n = 17) were interviewed in the outpatient clinics of a tertiary care pediatric center regarding their perceptions of the physical and social impact of eight chronic diseases (epilepsy, asthma, diabetes, Down syndrome, arthritis, migraine, leukemia, human immunodeficiency virus [HIV] infection). Epilepsy was perceived to have a more adverse physical impact than all chronic illnesses except Down syndrome. The perception was that it more frequently caused mental handicap, injured the afflicted individual and bystanders, and led to death. Epilepsy was also perceived to have a more negative social impact, particularly on behavior, honesty, popularity, adeptness at sports, and fun. Significantly more adolescents expressed reluctance to befriend peers with epilepsy, both from their own and their perceived parental perspectives. Having a chronic disease did not generally alter the adolescents' perceptions of peers with chronic disease. However, cases with epilepsy ranked this disease to have less social impact than teens with other chronic diseases. In conclusion, adolescents consider epilepsy to have a greater physical and social impact than most chronic diseases. Educational efforts should focus on the “normality” of most persons with epilepsy and emphasize the low risk of injury when proper first aid is followed. ( J Child Neurol 2006;21:214—222; DOI 10.2310/7010.2006.00053).
Effects of a tailored text messaging intervention among diverse adults with type 2 diabetes: Evidence from the 15-month REACH RCT
Authors: Nelson Lyndsay A. , Greevy Robert A. , Spieker Andrew , Wallston Kenneth A. , Elasy Tom A. , Kripalani Sunil , Gentry Chad , Bergner Erin M. , LeStourgeon Lauren M. , Williamson Sarah E. , Mayberry Lindsay S.
Published: November 2020

Objective: Text
messaging interventions have high potential for scalability and to reduce health
disparities; however, more rigorous, long-term trials are needed. We examined
the long-term efficacy and mechanisms of a tailored text messaging intervention.

Research Design and Methods: Adults
with type 2 diabetes participated in a parallel-groups, 15-month randomized
trial, assigned to receive REACH (Rapid Education/Encouragement and
Communications for Health) for 12 months or control. REACH included interactive
texts and tailored texts addressing medication adherence, and non-tailored
texts supporting other self-care behaviors. Outcomes included HbA1c, diabetes
medication adherence, self-care, and self-efficacy.

Results: Participants (N=506)
were approximately half racial/ethnic minority and half were underinsured, had
annual household incomes <$35,000 USD and ≤ high school education; 11% were
homeless. Average baseline HbA1c was 8.6%±1.8%; 70.0±19.7 mmol/mol) with n=219
having HbA1c≥8.5% (69 mmol/mol) and half were prescribed insulin. Retention
was over 90%. Median response rate to interactive texts was 91% (interquartile
range 75%, 97%). The treatment effect on HbA1c at 6 months (-0.31%; 95% CI
[-0.61%, -0.02%]) was greater among those with baseline HbA1c≥8.5% (-0.74%; 95%
CI [-1.26%, -0.23%]), and there was not evidence of effect modification by race/ethnicity
or socioeconomic disadvantage. REACH
improved medication adherence and diet through 12 months, and self-efficacy
through 6 months. Treatment effects were not significant for any outcome at 15
months. REACH reduced barriers to adherence, but barrier reduction did not
mediate outcome improvements.

Conclusions: REACH
engaged at-risk patients in diabetes self-management and improved short-term
HbA1c. More than texts alone may be needed to sustain effects.
A Study to Assess the Behavioural and Psychological Symptoms in Patients with Dementia
Authors: Singh Dr. Manjit , Kaur Dr. Manmeet , Garg Dr. P. D. , Bala Dr. Neeru
Published: November 2020

Introduction: With the aging population, the prevalence of dementia is rising. The aim of the study was to assess the frequency of Behavioural and Psychological symptoms (BPSD) in patients with dementia. Materials and Methods: A semi-structured proforma was used to gather sociodemographic details including age, gender, educational status, economic status, living conditions, family and personal history of any psychiatric illness. Mini Mental Status Examination was administered to record the level of cognitive impairment. Neuropsychiatric Inventory (NPI) was used to assess the presence of behavioral and psychological symptoms of dementia (BPSD) in patients with dementia. Findings: Out of 54 patients, 53.7% were females and 46.3% were males. 61.12% were above 65 years of age. Most of them 51.85% were illiterate. 66.67% belong to rural background. 59.25% came from nuclear families. MMSE score distribution showed that 51.85% belong to mild dementia group. Mean MMSE score was 16.12+/-4.778 SD. On Neuropsychiatric Inventory (NPI), most common symptoms were apathy (70. 37%), agitation (64.8%), sleep disturbances (59.25%) followed by other symptoms. Mean item score was 27.84+/-17.58 SD. Mean distress score was 17.72+/-8.99 SD. Conclusion: BPSD are universally present in patients with dementia and cause significant caregiver distress.
Fatores que influenciam o processo de design do livro digital:
Authors: Dick Maurício Elias , Gonçalves Berenice Santos
Published: November 2020

As potencialidades do meio digital libertam o livro das restrições do meio físico. Assim, os limites que definem livros são expandidos, abarcando aplicativos e jogos interativos, entre outros. É preciso, portanto, se desprender dos elementos característicos do entorno impresso em benefício de outros exclusivos do ambiente digital para que o livro digital evolua para um modelo mais autônomo e distanciado da referência impressa. Nessa direção, é necessário que os livros digitais sejam projetados, desde o início, à luz das características materiais e imateriais das plataformas de uso e distribuição no ambiente digital. Este estudo, portanto, partiu do pressuposto que o processo de design do livro digital demanda perceber um conjunto próprio de elementos inter-relacionados que demonstrem a complexidade vigente do cenário editorial, frente às transformações trazidas pela digitalização e pela própria existência do livro digital. Nesse sentido, representa uma etapa de uma pesquisa mais ampla e teve como objetivo identificar elementos e relações que influenciam o processo de design do livro digital. Com uma abordagem qualitativa, foram realizadas nove entrevistas semiestruturadas a partir da prática de profissionais que atuam na concepção e produção de livros digitais. Para o tratamento de dados, utilizou-se o método de análise de conteúdo e a técnica de análise categorial com o auxílio do software de análise de dados qualitativos ATLAS.ti. Em conjunto com os achados na literatura, os resultados da pesquisa permitiram a identificação dos principais fatores de influência do processo de design do livro digital em três diferentes níveis: primários (Conteúdo, Tecnologia e Leitor), secundários (Autor, Outros Agentes, Editor, Gestão do Negócio e Distribuidor) e terciários (Livro Impresso, Direitos Digitais, Livros Digitais Similares e Players Tecnológicos).
CONTINUIDADES Y DISCONTINUIDADES EN LA TRADUCCIÓN DE LAS LOCUCIONES PREPOSITIVAS EN LOS ROMANCEAMIENTOS BÍBLICOS MEDIEVALES
Authors: CODITA Viorica
Published: November 2020

Continuities and Discontinuities in the Translations of Prepositional Phrases in Medieval Biblical Texts. In this work we present an analysis of prepositional phrases in two contemporary translations, Biblia prealfonsí and the biblical part of General Estoria 4, on the basis of the Book of Ecclesiasticus. The aim of this study is to describe the state of variation of prepositional phrases in 13th century, delineating the similarities and divergences of solutions, and also to try to elucidate how much interferes the original Latin text, Vulgata, in the use of the prepositional phrases.
REZUMAT. Continuităţi şi discontinuităţi în traducerea locuţiunilor prepoziţionale în versiunile biblice medievale. În studiul de faţă, sunt analizate locuţiunile prepoziţionale din două traduceri medievale castiliene din secolul al XIII-lea, Biblia prealfonsí şi partea biblică din General Estoria 4, pornind de la Eclesiast. Se abordează statutul variaţional al construcţiilor prepoziţionale într-o perioadă concretă, insistându-se atât asupra coincidenţelor şi a divergenţelor, cât şi a gradului de interferenţă al textului original latin, Vulgata, în uzul locuţiunilor prepoziţionale.
Cuvinte-cheie: locuţiuni prepoziţionale, traduceri biblice castiliene, limbi în contact, Evul Mediu.
CASE MARKING IN ISTRO-ROMANIAN
Authors: GEANĂ Ionuț
Published: November 2020

Case Marking in Istro-Romanian. This paper focuses on the key elements of case marking in Istro-Romanian (IR). Similar to Daco‑Romanian, IR has a four-case system (nominative, accusative, genitive, dative), added by the vocative (not to be dealt with specifically in this paper). As a member of the so‑called Balkan Sprachbund, IR nouns oppose nominative-accusative to genitive‑dative. Pronouns, on the other hand, show a full paradigm, with specific forms for each case (in line with all other Eastern Romance varieties). For the oblique, IR has both stressed/strong and non-stressed/clitic forms, however they have a different distribution than in standard and sub‑standard Daco-Romanian. Differential object marking is virtually unheard of (with minor cases in northern IR). Indirect object doubling is rare(r), with possibly different pragmatic values than in Daco‑Romanian.
REZUMAT. Marcarea cazuală în istroromână. Lucrarea de față se axează pe elementele-cheie ale marcării cazuale în istroromână (IR). La fel ca în dacoromână, IR are patru cazuri (nominativ, acuzativ, genitiv, dativ), la care se adaugă vocativul (de care nu ne vom ocupa în mod special aici). Similar situației din alte varietăți ale uniunii lingvistice balcanice, substantivele din IR opun nominativul și acuzativul genitivului și dativului. Pe de altă parte, pronumele au o paradigmă completă, cu forme specifice pentru fiecare caz (la fel ca în celelalte varietăți romanice orientale). Pentru cazurile oblice, IR are atât forme accentuate/tari, cât și forme neaccentuate/clitice, care au totuși o distribuție diferită față de româna standard și substandard. Marcarea diferențiată a obiectului direct este practic necunoscută în IR (cu mici excepții în varietatea din nord). Dublarea obiectului indirect este (mai) rară, posibil cu valori pragmatice diferite de dacoromână.
Cuvinte-cheie: morfologie istroromână, topică istroromână, inovații morfosintactice, varietăți romanice orientale.
CONCORDANCES ROMANES ET CONVERGENCES BALCANO-ROMANES DANS LES DIALECTS ROUMAINS SUD-DANUBIENS. ASPECTS PHONETIQUES, MORPHOLOGIQUES ET SYNTAXIQUES
Authors: NEVACI Manuela
Published: November 2020

Romance Concordances and Balcano-Romance Convergences in the South-Danubian Romanian Dialects. Phonetic, Morphological, and Syntactic Aspects. This paper proposes to emphasise the linguistic similarities of South-Danubian Romanian dialects (Aromanian, Megleno-Romanian, Istro-Romanian) spoken in Albania, Croatia, R. of North Macedonia, Greece and Romania from the perspective of Romance and Balkan elements. We will take into consideration lexical aspects, from the point of view of linguistic contact with Balkan languages, as well as Romance elements that define these historical dialects of common Romanian. Our exposition is based on the broader theme of the relationship between genealogic (Romance features inherited from Latin, speaking of concordances in the Romance languages) and areal (convergences between the Aromanian and Megleno-Romanian dialects of the Romanian language and the languages spoken in the Balkan area). Through the presence of the Aromanian, Megleno-Romanian and Istro-Romanian dialects of Romanian in the Balkans, creating a bridge between Romània and Balkan, a convergence was attained on the one hand with the Romance languages, and, on the other, with Greek, Albanian North Macedonian as Balkan languages.
REZUMAT. Concordanțe romanice și convergențe balcano-romanice în dialectele româneşti sud-dunărene. Aspecte fonetice, morfologice și sintactice. Articolul nostru are în vedere evidenţierea concordanţelor lingvistice ale dialectelor româneşti sud-dunărene (aromân, meglenoromân, istroromân) din Albania, Grecia, Republica Macedonia de Nord, Croaţia şi România, din perspectiva elementelor romanice şi a celor balcanice. Studiul nostru se bazează pe bibliografia de specialitate şi pe anchetele de teren desfăşurate în ţările menţionate. Cercetarea se întemeiază pe tematica mai largă a raportului dintre genalogic (particularităţi romanice moştenite de română din latină, vorbind de concordanţe la nivelul limbilor romanice) şi areal (convergenţe între dialectele aromân şi meglenoromân al limbii române şi limbile vorbite în aria balcanică).
Cuvinte-cheie: Dialectele româneşti sud-dunărene, dialect aromân, dialect meglenoromân, dialect istroromân, sistem dialectal morfologic și sintactic.
APUNTES PARA LA HISTORIA DE UNA FRASEOLOGÍA DEL ESPAÑOL AMERICANO
Authors: SÁNCHEZ-MÉNDEZ Juan Pedro
Published: November 2020

Notes for the History of a Phraseology of American Spanish. This paper presents the characteristics that would define the historical Hispano-American phraseology as opposed to the European Spanish one. Phraseology is one of the areas in which the greatest variation is perceived among the different Hispanic countries. In this paper I will try to point out the main historical foundations that would explain this variation and the characteristics assumed by what we call the indian or colonial phraseology. This would be the origin of what today we can consider a phraseological Americanism, which presents some characteristics that allow establishing its historical study differentiated from the European Spanish and justifies the necessary diastematic vision of the general historical phraseology of the Spanish language.
Rezumat. Note asupra istoriei frazeologismelor hispano-americane. În cadrul acestui articol, vom prezenta trăsăturile ce caracterizează frazeologia istorică hispano-americană spre deosebire de cea europeană. Frazeologia e unul dintre domeniile cu cea mai mare variaţie în diferitele ţări hispanice, de aceea, în acest studiu, vom încerca să subliniem principalele fundamente istorice care ar explica această variaţie, precum şi caracteristicile aşa-numitei frazeologii indiene sau coloniale. Aceasta ar constitui baza a ceea ce, astăzi, am putea numi americanism frazeologic, ale cărui caracteristici permit stabilirea studiului său istoric diferit de cel al spaniolei europene şi justifică viziunea diasistematică necesară pentru frazeologia istorică generală spaniolă.
Cuvinte-cheie: frazeologia istorică hispano-americană, americanism frazeologic, frazeologia indiană/colonială, istoria spaniolei americane.
Los cajones
Authors: Miraglia Sol
Published: November 2020

En primera persona, la encargada de custodiar y preservar las más de cuarenta mil imágenes del Foto estudio Luisita relata cómo fueron los primeros acercamientos con Luisa y con Graciela Escarria, los motivos que la llevaron a poner en valor las fotografías, y el trabajo de resguardo y de investigación en el archivo.
Pharmacy Programs & Evaluations
Authors: 2018 MIDWEST SAPH
Published: November 2020

Article 1: Positive Deviants for Medication Therapy Management: Behaviors and Delivery Strategies That Distinguish the Highest Performing Community Pharmacies Omolola A. Adeoye, PharmD; Leslie M. Lake, PharmD; Karen S. Hudmon, DrPH, MS; Alan J. Zillich, PharmD, FCCP; Margie E. Snyder, PharmD, MPH, FCCPArticle 2: Establishing Community Pharmacy Links to Clinic Electronic Medical Records (EMRs) William R. Doucette, PhD; William Evans, Pharmacy StudentArticle 3: Error Types with Use of Medication-Related Technology: A Mixed Methods Research Study Shweta R. Shah, MS; Kimberly A. Galt, PharmD, PhD; Kevin T. Fuji, PharmD, MAArticle 4: Satisfaction and Prevalence of Plan Switching for Individuals Utilizing a Pharmacy Medicare Part D Consultation Service Logan T. Murry, PharmD; Huwein Deng, Pharmacy Student; Brandon Gerleman, PharmD; Julie Urmie, PhDArticle 5: Prevalence of Fall-Risk Increasing Drugs Use among Community Dwelling Older Adults Chi-Yin Liao, BS, Graduate StudentArticle 6: Integration of a Fall Risk Assessment Model into Community Pharmacist Workflow Amna Rizvi-Toner, BS, PharmD/MPH Candidate; Korey A. Kennelty, PharmD, MS, PhD, BCGP
Catálogo de publicaciones del Cechiver-UV
Authors: China-Veracruz Centro de Estudios
Published: November 2020

Catálogo de publicaciones delCechiver-UV
La narración como inminencia del cierre. Conversación con Ricardo Piglia
Authors: Cohen Marcelo
Published: November 2020

Desde sus primeros volúmenes de ficción hasta sus tesis sobre el cuento y sus ensayos sobre la lectura, Ricardo Piglia ha visto en los finales de los relatos un motivo capital para interrogar una y otra vez las formas de la literatura e indagar decisivamente cómo operan. Este número era la ocasión indicada para que otra parte mantuviera una conversación con él.
Conflicto armado y medios corporativos. El caso del Ejército de Liberación Nacional ELN
Authors: Trujillo Baca Alexander
Published: November 2020

Cuando en la década de 1960 corría por Colombia los ideales cubanos que fortalecerían los orígenes campesinos y revolucionarios del Ejército de Liberación Nacional (En adelante, ELN), la prensa completaba más de un siglo narrando ideales políticos de la República, la radio más de dos décadas emitiendo su señal por el territorio (a través de la Radio Nacional de Colombia) y la televisión escasos años (con Televisión Comercial –TVC-) proyectando en la pantalla a blanco y negro los rostros del país y sus guerras.
Writing Process Approach and Its Effect on Studentsâ€™ Writing Anxiety and Performance
Authors: Kurniasih Kurniasih , Sholihah Fitri Awaliyatus , Umamah Atik , Hidayanti Ika
Published: November 2020

This study aims at investigating the effect of the process approach on student writing anxiety and performance. Teachers should find ways to cope with anxiety as it is known as the negative predictor of studentsâ€™ writing performance. Fifteen students participated in this study. They were assigned to write an argumentative essay under the topic â€˜should national exam be banned?â€. The treatment was given following the writing stages, from outlining to publishing. SLWAI questionnaire was distributed before and after the treatment to measure the effectiveness of the process approach on studentsâ€™ anxiety. The findings indicated that students writing anxiety decreases from 71.27 to 63.20, which means that the anxiety level goes down from high to moderate anxiety. The second findings informed us that there is a significant difference in students writing performance after the treatment with the level of significant .000. It can be said that the writing process approach has a significant effect on students writing anxiety and performance. The pedagogical implication is also discussed.
Sistem Monitoring Kendaraan Dinas Secara Real-Time Dengan Menggunakan Metode Geo-fence Berbasis Android
Authors: Prima Dwiyana Nugraha  , Derisma  , Nefy Puteri Novani
Published: November 2020

This study aims to be a means in preventing the misuse of official vehicles. By using a geofencing system to monitor vehicles using Android. Because many government employees use official vehicles for personal use. In this system an application that has been installed with a geofencing system is installed on the smartphone. Then the system can track the gps of the vehicle you want to monitor. So that official vehicles can be monitored for their existence and the use of vehicles in a government agency can be used effectively and there is no misuse of state facilities.
The existence of karabhat symbolic communication in Tanean Lanjhang community in Madurese society
Authors: Sudahri Sudahri , Ida Rachmah
Published: November 2020

Tanean Lanjhang (the long yard) is a large yard with traditional Madurese houses built in a row and facing each other. ‘Tanean’ means the distance between one house and another. Meanwhile, ‘Lanjhang’ is the area of the yard that extends along the Tanean. The group that inhabits the Tanean Lanjhang is a genealogical group from one lineage, usually from the maternal (matrilineal) line. These social phenomena happened in Sanatengah Village, Pasean District, Pamekasan Regency. The current research used descriptive qualitative methodology and studied the people of Sanatengah Village, Pasean Subdistrict, Pamekasan Regency and all its community components. The results of this study indicated that the Tanean Lanjhang community is a social order that maintains the influence of relatives in life. Communication between relatives exists because of the role of Pangaseppo, or the eldest person of the family; Oreng Toah (parents), or mother and father; and Taretan, or siblings. Those were the three relatives who have the highest position in Madurese society and must be obeyed by every household members. In maintaining kinship, marriage is also arranged within close relatives, such as between cousins, uncles, and nieces. This study concluded that the Tanean Lanjhang upholds the values of kinship. Furthermore, kinship is not only built based on traditional houses but also the tradition of marriage between close relatives.
Lokale und auswärtige Musik in Chorbüchern mit polyphoner Musik der Kathedralen von Guatemala und Mexiko
Authors: Morales Abril Omar
Published: November 2020

(Übersetzung von Horst Pietschmann)
Efficient C3-alkylsulfenylation of indoles under mild conditions using Lewis acid-activated 8-quinolinethiosulfonates.
Authors: galardon erwan
Published: November 2020

The importance of sulfur-containing compounds in various fields, ranging from material science1-2 to medicinal chemistry, 3 has called for the development of synthetic strategies to form carbon-sulfur (C-S) bonds. Thus, numerous approaches based on the nucleophilicity of thiols have been designed over the years, which mostly use air-sensitive noble metal catalysts.4- 9 At the opposite, the use of electrophilic sulfur reagents is also a powerful, more eco-friendly approach, in particular for the sulfenylation of C-H bonds into C-S bonds.10-11 In this context, the sulfenylation of indoles (Equation 1) has become a benchmark reaction to develop and test new sulfenyl transfer reagents, because indoles are good nucleophiles and their occurrence in many natural products or biological active compounds makes them attractive synthetic targets.12-14 For instance, metal-catalyzed or metal-free protocols have been proposed, in which disulfides, sulfinic acid and their salts, sulfonyl chlorides, sulfonylhydrazine, or Nthiophtalimides are used as source of electrophilic sulfur.10,15-16 Thiosulfonates (RSO2SR’) are another class of emerging17 reagents, which were also studied for C-S bond formation18-20 and for indole sulfenylation.21 However, despite the large pool of sulfenylation agents listed above, the difficult activation of the chalcogen centre essentially limits these reagents to the formation of C-S(aryl) bonds. On the other hand, the transfer of alkylsulfenyl groups requires harsher activating conditions and is so far still limited