bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of the geriatric assessment in older caregivers of older adults with cancer to guide supportive care.
Authors: Kadambi Sindhuja G , Stupia Lisa , Wang Lu , Cacciatore Jenna , Kehoe Lee , Gilmore Nikesha , Norton Sally , Mohile Supriya Gupta , Magnuson Allison
Published: October 2023

224

Background: Older caregivers of older patients with cancer are at high risk for adverse physical and psychological outcomes. Performing a caregiver geriatric assessment (GA) may help identify caregivers at increased risk of adverse outcomes and guide supportive care strategies. In this study, we aimed to determine the feasibility of a GA to evaluate age-related conditions, and physical and emotional health of both patients and caregivers. Methods: Caregivers aged 65+ and patients aged 65+ with diagnosis of cancer receiving a new line of cancer treatment and caregivers aged 65+ were recruited (Goal 60 dyads; current N=40). Patient and caregiver physical and emotional health was captured using the GA which included assessment of physical function (activities of daily living [ADLs], instrumental activities of daily living [IADLs], Short Physical Performance Battery [SPPB], fall history), comorbidity, psychological health (Geriatric Depression Scale [GDS], General Anxiety Disorder-7 [GAD-7]), cognition (Montreal Cognitive Assessment [MOCA] or Blessed Orientation Memory Concentration [BOMC]), Social Support (Older Americans Resources and Services [OARS] Social Support), polypharmacy, nutrition, caregiver Environmental Mastery, and Modified Caregiver Strain Index. Results: Of 40 dyads who have consented, 17 dyads (42%) completed the GA, 14 dyad GAs are pending (35%), eight have withdrawn (20%), and one was lost to follow-up (2.5%). Mean time for caregivers to complete self-reported GA assessment was 47 minutes (range 20-120 minutes) and return to study staff was 5 days (range 0-22 days). Caregivers had mean age 78 years (range 65-85), 100% white, 94% female, and 94% spouses. Caregivers had high prevalence of age-related conditions, including comorbidities (mean 3.7), impairments in ADLs (24%), IADLs (31%), and physical function (55%). More patients than caregivers screened positive for depression (29% vs 12%) and anxiety (17% vs 6%). Caregivers reported high mastery (Ryff subscale, mean 38, range 26-49) and low strain (4.4, range 0-16). Conclusions: The GA is feasible to use in older cancer caregivers to help identify aging related conditions that may influence caregiving ability. Future work should identify how GA in older cancer caregivers can be used to identify intervention strategies to optimize caregiving abilities and improve outcomes in both older adults with cancer and their caregivers. Clinical trial information: NCT05244915 .[Table: see text]
Feasibility of screening for and matching adolescents and young adults with cancer to a community-partnered financial and health-related social needs navigation intervention.
Authors: Beauchemin Melissa P , Solomon Samrawit , Gallagher Kathleen D. , Angove Rebekah SM , Kahn Justine , Hershman Dawn L.
Published: October 2023

281

Background: Adolescents and young adult (AYAs, defined by the NCI as aged 15-39) cancer survivors experience high rates of financial toxicity, and the risk for and severity of financial toxicity are associated with unmet health-related social needs (HRSN: e.g., difficulty affording housing, food, transportation, insurance). Financial navigation may be an effective intervention to reduce financial toxicity and improve health outcomes. We have adapted an AYA- and caregiver-informed intervention to reduce financial burden among English- and Spanish-speaking AYAs on active cancer treatment. We report on the preliminary feasibility of a baseline financial and HRSN assessment among AYAs and navigating AYAs with unmet needs to the Patient Advocate Foundation (PAF), our community-partner, at a large, urban comprehensive cancer center. Methods: AYAs aged 15-39 years who speak English or Spanish and are receiving curative-intent treatment for cancer completed a baseline needs assessment that assessed financial and HRSN. The following indicates a positive screen for financial or HRSN: Comprehensive Score for Financial Toxicity (COST, AYA) score < 22 or Personal Financial Wellness Scale (PFWS, caregiver) ≤ 4; Any food, housing, transportation, utility insecurity or uninsurance. Participants are also distinctly offered connection to our community partner regardless of screening response. Participants with a positive screen will receive a needs navigation intervention in partnership with PAF for 6 months. We report the initial uptake, rates of baseline assessment completion, and reasons for screening positive in preparation for the next wave of recruitment. Results: Of 12 AYAs approached, eleven participated in the baseline assessment: one was completed by a parent proxy, and seven caregivers concurrently completed a dyadic assessment. In total, of the 11 AYAs, six screened positive for one or more unmet needs, thus meeting criteria to receive the financial and HRSN navigation intervention. Additionally, one AYA and caregiver dyad requested connection to the intervention in the absence of a positive screen. Unmet needs included housing insecurity (n=3), transportation (n=2), utilities (n=1); all six AYAs who screened positive met criteria for financial toxicity. Among dyadic responses, 5 of 6 were concordant. Conclusions: Preliminary data support the feasibility of screening AYAs for and matching them to a financial and HRSN navigation intervention. Next steps will include recruitment and expansion to demonstrate feasibility of the intervention and explore impact on financial and HRSN as well as health outcomes.
Community driven support platform BlueHQ: An innovative solution to address the needs of patients with colorectal cancer.
Authors: Newcomer Kim , Fenstermacher David , Riedesel Monica ,   Never Too Young Task Force
Published: October 2023

330

Background: Colorectal cancer (CRC) is the third-most commonly diagnosed cancer and the second-leading cause of cancer death in men and women combined in the United States. In efforts to manage the disease, patients and caregivers turn to various tools and resources for financial assistance, information dissemination, emotional and peer support, and treatment planning, among other critical issues and needs they face. The Colorectal Cancer Alliance (the Alliance) created BlueHQ to provide patients and caregivers with a resource solution that encompasses all potential areas of need. Methods: A survey aimed at understanding needs, barriers, and quality improvement opportunities was disseminated via the Alliance's Blue Hope Nation community for two weeks and by email. One hundred sixty-seven colorectal cancer patients and forty caregivers of colorectal cancer patients completed the survey. Results: Patients and caregiver respondents report reliance on external tools and resources to manage disease and support information. Of the support methods, patient respondents reported using social media (46.11%); notebooks, journals, and planners (45.41%); online articles (44.91%); the Blue Hope Nation Facebook group (41.32%); cancer discussion boards (35.33%); and spiritual or religious advice (29.94%). To minimize diagnosis-related stressors, patients reported seeking financial assistance, local peer support and groups, and mental health help. To provide more efficient care and limit stress, the community suggested financial help, communication and support from other patients and caregivers, and informational resources. Conclusions: These survey results are consistent with other published learnings about patient and caregiver reliance on support tools and highlight the myriad resources that patients and caregivers currently use for managing CRC. BlueHQ is a support solution that provides patients and caregivers with access to information and resources tailored to users’ specified profiles, including molecular characteristics of the tumor. Users can also store documents and information from healthcare encounters, creating a longitudinal record and tracking disease progression. In the age of precision oncology, BlueHQ ensures patients and users are presented with personalized educational materials and multimedia resources to help manage their disease and bridge the gaps in patient support. BlueHQ was explicitly designed to connect the CRC community to the latest therapeutic and clinical research resources to improve outcomes and quality of life for all CRC patients.
Wellbeing and burnout among oncology fellows compared to prior fellows and current practicing oncologists: An ASCO State of Cancer Care in America (SOCCA) trend analysis.
Authors: Subbiah Ishwaria M. , Schenkel Caroline , Kirkwood Margaret Kelsey , Levit Laura A. , Shanafelt Tait D.
Published: October 2023

47

Background: Burnout impacts oncology clinicians across their professional lifecycle. To better understand clinician wellbeing and the role of fellowship training, we characterized trends in oncology fellows’ burnout and perception of preparedness during training. Methods: As an ASCO SOCCA initiative, all medical oncology fellows taking the 2023 ASCO Medical Oncology In-Training Exam (ITE) were invited to complete an optional post-ITE professional wellbeing survey. Fellows were asked 1 item on fatigue (on a 0-10 Likert scale, 10 = “as bad as can be”), 1 item on satisfaction with work-life integration (WLI) and 2 Maslach Burnout Inventory (MBI) items on emotional exhaustion (EE) and depersonalization (DP), each scored on a 1-7 scale, >5 being high. Per convention, respondents with a high EE and/or DP were categorized as having burnout. 2023 ITE responses were compared to (1) 2013 ASCO Fellows Post-ITE survey (n=1345),1 (2) 2012-13 ASCO survey of practicing oncologists (n=1117),2 and (3) 2023 ASCO survey of practicing oncologists (n=328; 26% tagged as early career, using age <40 as proxy; 64% in academia). Results: 2231 fellows who took the ITE in 2023. Responses from 1568 first (33%), second (36%) and third year (31%) fellows who responded to at least one wellbeing item are included in this analysis. Compared to 10 years prior, oncology fellows in 2023 reported less burnout (20% in 2023 vs 34% in 2013, p<.001) and higher satisfaction with WLI (50% in 2023 vs 34% in 2013; p<.001). Fellows across both 2013 and 2023 studies reported higher satisfaction with WLI with advancing fellowship year (1-3). The 2013 analyses found no statistically significant difference in EE, DP or overall burnout between fellows and practicing oncologists. However, in 2023, the prevalence of high EE, DP and burnout was significantly lower in fellows vs both all and early career practicing oncologists (all p<.005, Table). Most (72%) fellows in 2023 felt their training is adequately preparing them to manage burnout in future practice. Conclusions: Oncology fellows in 2023 reported significantly less burnout and higher WLI satisfaction than fellows in 2013 and current practicing oncologists. Most fellows felt prepared to manage burnout in future practice. The higher prevalence of burnout in early career oncologists vs fellows suggests a gap between expectations of practice during training and the actual experience of oncology practice. (1) Shanafelt et al: JCO 32(27), 2014. (2) Shanafelt et al: JCO 32(11), 2014. [Table: see text]
Don't You Worry 'bout a Thing: Harnessing the Power of Music to Improve Emotional Health in Oncology
Authors: Peppercorn Jeffrey , Miller Earl K. , Hasselmo Michael E.
Published: October 2023

In this editorial, Drs Peppercorn and noted neuroscientists Miller and Hasselmo comment on a recent randomized trial of music to reduce stress during infusion, noting that our understanding of the brain supports a unique and particularly effective role for music in improving mood and reducing distress for patients with cancer
Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
Authors: Bahnassy Shaymaa , Stires Hillary , Jin Lu , Tam Stanley , Mobin Dua , Balachandran Manasi , Podar Mircea , McCoy Matthew D , Beckman Robert A , Riggins Rebecca B
Published: October 2023

Breast tumors overexpressing human epidermal growth factor receptor (HER2) confer intrinsic resistance to endocrine therapy (ET), and patients with HER2/estrogen receptor–positive (HER2+/ER+) breast cancer (BCa) are less responsive to ET than HER2–/ER+. However, real-world evidence reveals that a large subset of patients with HER2+/ER+ receive ET as monotherapy, positioning this treatment pattern as a clinical challenge. In the present study, we developed and characterized 2 in vitro models of ET-resistant (ETR) HER2+/ER+ BCa to identify possible therapeutic vulnerabilities. To mimic ETR to aromatase inhibitors (AIs), we developed 2 long-term estrogen deprivation (LTED) cell lines from BT-474 (BT474) and MDA-MB-361 (MM361). Growth assays, PAM50 subtyping, and genomic and transcriptomic analyses, followed by validation and functional studies, were used to identify targetable differences between ET-responsive parental and ETR-LTED HER2+/ER+ cells. Compared to their parental cells, MM361 LTEDs grew faster, lost ER, and increased HER2 expression, whereas BT474 LTEDs grew slower and maintained ER and HER2 expression. Both LTED variants had reduced responsiveness to fulvestrant. Whole-genome sequencing of aggressive MM361 LTEDs identified mutations in genes encoding transcription factors and chromatin modifiers. Single-cell RNA sequencing demonstrated a shift towards non-luminal phenotypes, and revealed metabolic remodeling of MM361 LTEDs, with upregulated lipid metabolism and ferroptosis-associated antioxidant genes, including GPX4. Combining a GPX4 inhibitor with anti-HER2 agents induced significant cell death in both MM361 and BT474 LTEDs. The BT474 and MM361 AI-resistant models capture distinct phenotypes of HER2+/ER+ BCa and identify altered lipid metabolism and ferroptosis remodeling as vulnerabilities of this type of ETR BCa.
The shift to 3D growth during embryogenesis of kelp species, atlas of cell division and differentiation of Saccharina latissima
Authors: Theodorou Ioannis , Charrier Bénédicte
Published: October 2023

In most organisms, 3D growth takes place at the onset of embryogenesis. In some brown algae, 3D growth occurs later in development, when the organism consists of several hundred cells. We studied the cellular events that take place when 3D growth is established in the embryo of the brown alga Saccharina, a kelp species. Semi-thin sections, taken from where growth shifts from 2D to 3D, show that 3D growth first initiates from symmetrical cell division in the monolayered lamina, and then is enhanced through a series of asymmetrical cell divisions in a peripheral monolayer of cells called the meristoderm. Then, daughter cells rapidly differentiate into cortical and medullary cells, characterised by their position, size and shape. In essence, 3D growth in kelps is based on a series of differentiation steps that occur rapidly after the initiation of a bilayered lamina, followed by further growth of the established differentiated tissues. Our study depicts the cellular landscape necessary to study cell-fate programming in the context of a novel mode of 3D growth in an organism phylogenetically distant from plants and animals.
CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility
Authors: Shimada Keisuke , Ikawa Masahito
Published: October 2023

Sperm flagellum plays a crucial role in male fertility. Here, we generated Ccdc183 knockout mice using the CRISPR/Cas9 system to reveal the protein function of the testis-specific protein CCDC183 in spermiogenesis. We demonstrated that the absence of CCDC183 causes male infertility with morphological and motility defects in spermatozoa. Owing to the lack of CCDC183, centrioles after elongation of axonemal microtubules do not connect the cell surface and nucleus during spermiogenesis, which causes subsequent loss of cytoplasmic invagination around the flagellum. As a result, the flagellar compartment does not form properly and cytosol-exposed axonemal microtubules collapse during spermiogenesis. In addition, ectopic localization of accessory structures, such as the fibrous sheath and outer dense fibers, and abnormal head shape as a result of abnormal sculpting by the manchette are observed in Ccdc183 knockout spermatids. Our results indicate that CCDC183 plays an essential role in cytoplasmic invagination around the flagellum to form functional spermatozoa during spermiogenesis.
Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis
Authors: Mao Aihua , Li Zhuyun , Ning Guozhu , Zhou Zhengrong , Wei Chiju , Li Jianchao , He Xinyu , Wang Qiang
Published: October 2023

Primitive erythropoiesis serves a vital role in embryonic development, generating primitive red blood cells responsible for transportation of oxygen throughout the body. Although diverse niche factors are known to function in definitive hematopoiesis, the microenvironment contributing to primitive hematopoiesis remains largely elusive. Here, we report that platelet-derived growth factor (PDGF) signaling is required for erythroid progenitor differentiation in zebrafish. Ablating pdgfαa (also known as pdgfaa) and pdgfαb (also known as pdgfab) or blocking PDGF signaling with an inhibitor impairs erythroid progenitor differentiation, thus resulting in a significant decrease in the number of erythrocytes. We reveal that pdgfαb is expressed in sclerotomal cells, and that its receptor genes, pdgfra and pdgfrb, are expressed in the adjacent erythroid progenitor cells. Sclerotome-specific overexpression of pdgfαb effectively restores primitive erythropoiesis in pdgfαa−/−;pdgfαb−/− mutant embryos. In addition, we have defined ERK1/2 signaling as a downstream pathway of PDGF signaling during embryonic erythropoiesis. Taken together, our findings indicate that PDGF signaling derived from sclerotome functions as a niche cue for primitive erythropoiesis.
The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility
Authors: Dunleavy Jessica E. M. , Graffeo Maddison , Wozniak Kathryn , O'Connor Anne E. , Merriner D. Jo , Nguyen Joseph , Schittenhelm Ralf B. , Houston Brendan J. , O'Bryan Moira K.
Published: October 2023

Katanins, a class of microtubule-severing enzymes, are potent M-phase regulators in oocytes and somatic cells. How the complex and evolutionarily crucial, male mammalian meiotic spindle is sculpted remains unknown. Here, using multiple single and double gene knockout mice, we reveal that the canonical katanin A-subunit KATNA1 and its close paralogue KATNAL1 together execute multiple aspects of meiosis. We show KATNA1 and KATNAL1 collectively regulate the male meiotic spindle, cytokinesis and midbody abscission, in addition to diverse spermatid remodelling events, including Golgi organisation, and acrosome and manchette formation. We also define KATNAL1-specific roles in sperm flagellum development, manchette regulation and sperm-epithelial disengagement. Finally, using proteomic approaches, we define the KATNA1, KATNAL1 and KATNB1 mammalian testis interactome, which includes a network of cytoskeletal and vesicle trafficking proteins. Collectively, we reveal that the presence of multiple katanin A-subunit paralogs in mammalian spermatogenesis allows for ‘customised cutting’ via neofunctionalisation and protective buffering via gene redundancy.
Metabolic switches during development and regeneration
Authors: Mahmoud Ahmed I.
Published: October 2023

Metabolic switches are a crucial hallmark of cellular development and regeneration. In response to changes in their environment or physiological state, cells undergo coordinated metabolic switching that is necessary to execute biosynthetic demands of growth and repair. In this Review, we discuss how metabolic switches represent an evolutionarily conserved mechanism that orchestrates tissue development and regeneration, allowing cells to adapt rapidly to changing conditions during development and postnatally. We further explore the dynamic interplay between metabolism and how it is not only an output, but also a driver of cellular functions, such as cell proliferation and maturation. Finally, we underscore the epigenetic and cellular mechanisms by which metabolic switches mediate biosynthetic needs during development and regeneration, and how understanding these mechanisms is important for advancing our knowledge of tissue development and devising new strategies to promote tissue regeneration.
Sex-Specific Impact of CARM1 in Skeletal Muscle Adaptations to Exercise
Authors: vanLieshout Tiffany L. , Stouth Derek W. , Raziee Rozhin , Sraka Anne-Sophie J. , Masood Hooriya A. , Ng Sean Y. , Mattina Stephanie R. , Mikhail Andrew I. , Manta Alexander , Ljubicic Vladimir
Published: October 2023

Purpose

The purpose of this study was to determine how the intersection of coactivator-associated arginine methyltransferase 1 (CARM1) and biological sex impacts skeletal muscle adaptations to chronic physical activity.

Methods

12-week-old female (F) and male (M) wild-type (WT) and CARM1 skeletal muscle-specific knockout mice (mKO) were randomly assigned to sedentary (SED) or voluntary wheel running (VWR) experimental groups. For 8 weeks, the animals in the VWR cohort had volitional access to running wheels. Subsequently, we performed whole-body functional tests, and 48 hours later muscles were harvested for molecular analysis. Western blotting, enzyme activity assays, as well as confocal and transmission electron microscopy (TEM) were used to examine skeletal muscle biology.

Results

Our data reveal a sex-dependent reduction in VWR volume caused by muscle-specific ablation of CARM1, as F CARM1 mKO mice performed less chronic, volitional exercise than their WT counterparts. Regardless of VWR output, exercise-induced adaptations in physiological function were similar between experimental groups. A broad panel of protein arginine methyltransferase (PRMT) biology measurements, including markers of arginine methyltransferase expression and activity, were unaffected by VWR, except for CARM1 and PRMT7 protein levels, which decreased and increased with VWR, respectively. Changes in myofiber morphology and mitochondrial protein content showed similar trends among animals. However, a closer examination of TEM images revealed contrasting responses to VWR in CARM1 mKO mice compared to WT littermates, particularly in mitochondrial size and fractional area.

Conclusions

The present findings demonstrate that CARM1 mKO reduces daily running volume in F mice, as well as exercise-evoked skeletal muscle mitochondrial plasticity, which indicates that this enzyme plays an essential role in sex-dependent differences in exercise performance and mitochondrial health.
Analysis of carbon nano particle variant as the propellant fuel to increase specific impulses of rockets
Authors: Navalino RDA , Muda NRS , Hafizah MAE , Ruyat Y
Published: October 2023

Background: This study compares propellant fuels' specific thrust and impulse parameters using nanocarbon variant fuels from coconut shells and coal. Specific impulses and impulses are essential parameters that determine rocket performance. The specific thrust and impulses are influenced by fuel type, material composition, heat flow, and burning time parameters. The characteristics of nanocarbon as a fuel are proven to have high-value features and a long combustion time. This parameter is essential to add value to specific thrusts and impulses.

Methods: The method to prove the quality of solid fuel material was done experimentally. The composition of the propellant fuel variant mixed with NH4ClO4 as an oxidizer through the printing process and sample testing was carried out using scanning electron microscope (SEM), X-ray diffraction analysis (XRD), combustion time, and specific impulse tests.

Results: Test results with the composition of CBK2 (Coconut Shell + NH4ClO4 + Binder + Al = 15: 70: 10: 5) produced a specific impulse of 267 seconds or an increase of 37 seconds without carbon. CBB2 (Coal + NH4ClO4 + Binder + Al = 15: 70: 10: 5) produced a specific impulse of 261 seconds or an increase of 31 seconds.

Conclusions: The composition of nanocarbon as a solid fuel propellant has been proven to increase a rocket's thrust and specific impulses. After all the material variants have been tested for thrust and specific impulse, the best rocket propellant is CBK2.
Prevalence of tooth wear diseases in patients with diabetes and its impact on the quality of life in Dakshina Kannada population: a cross sectional study
Authors: Sinha Poojakumari , Nayak Sangeeta , Sehgal Lavangi , Shenoy Kudupi Ramya
Published: October 2023

Background Early detection and management of tooth wear (TW) has not been given due consideration in the dental profession. Thus, this study aimed to explore the prevalence of TW in adults with diabetes in Dakshina Kannada population using the Basic Erosive Wear Examination (BEWE) and recording its impact on quality of life using the Oral Health Impact Profile (OHIP-14). Methods In total, 236 dentate adults with diabetes and TW, who visited the Manipal College of Dental Sciences, Mangalore were recruited to the study. Assessment of TW was done using BEWE during examination of each participant and was categorized as none, mild, moderate, and severe. Impact of TW on quality of life was assessed using the OHIP-14. Results Overall, 81 (34.30%) individuals had a poor score on the basic erosive tooth index, 82 (34.70%) had a medium score, . The level of TW, both moderate and severe (high), affected quality of life. Erosion, abrasion and attrition were seen in a large proportion of the study population. The diabetic status of the individual was collected from their medical file. The HbA1C level was found to range from good, fair and poor control. The quality of life among the study population was affected because of TW and diabetes. Few participants had hypertension along with diabetes. The majority of study participants were on oral hypoglycaemic agents. Participants used tooth brushes and tooth paste and brushing frequency varied between once or twice daily. Conclusions In the study population, there were moderate and severe TW patterns. Quality of life was found to be impacted by TW. Dental professionals must give proper consideration to the influence of TW on quality of life in addition to clinical findings. This will make it easier to offer preventive or restorative management depending on the situation.
Designing Tasks Aimed at Developing the Fundamentals of Functional Literacy in Primary Schoolchildren
Authors: Timofeeva L. , Butrimova I.
Published: October 2023

The article examines personal, meta-subject and subject-specific results of students mastering primary general education programs, directly related to the formation of the foundations of functional literacy. Definitions of the concepts “educational-cognitive task” and “educational-practical task” are given, as well as the main characteristics of developmental tasks built on their basis. Universal educational cognitive (research) and regulatory actions are identified that enable students to solve educational problems, as well as the stages of mastering them. The structural elements of developmental tasks associated with universal educational cognitive actions, which relate to basic logical actions and methods of working with information, are considered; a step-by-step process of their development is outlined. Examples of tasks are presented that meet generalized criteria characterizing the levels of mastery of the Basic Educational Program: knowledge, understanding, application, functionality. A matrix and algorithm for developing tasks have been compiled.
Preparing Students for Health-Oriented Activities with Younger Schoolchildren
Authors: Shukshina Svetlana , Borisova M. , Pavlova N. , Morozova L. , Korobova O.
Published: October 2023

Based on the conducted research, the article examines the problem of preparing future primary school teachers for health-oriented activities. The main research methods were system-analytical, comparative, questioning, and mathematical processing of empirical data. Data on the health status of younger schoolchildren and students is disclosed. The content of the concept of “health-oriented activity” is clarified and specified and its semantic characteristics are highlighted. The value of health and the role of a healthy lifestyle in the development of the younger generation are substantiated. The authors analyzed legislative and regulatory documents in the field of education from the perspective of the problem of developing a healthy lifestyle among the younger generation and youth. Contradictions have been identified between the professional requirements for a primary school teacher and the absence of this competency in the Federal State Educational Standard of Higher Education. The need for targeted and systematic training of future primary school teachers for health-oriented activities with students is substantiated. The results of the ascertaining experiment conducted on the basis of the Institute of Pedagogy and Psychology of Education of the Moscow City Pedagogical University and the Pedagogical Institute of Derzhavin Tambov State University, to identify the value of health and students’ readiness for health-oriented activities with younger schoolchildren. Conclusions are drawn about the formal approach and the insufficient focus of the professional training of future teachers on this type of activity with different age categories of students.
Formation of critical thinking personality in the context of the value-sense educational paradigm
Authors:   State Institution Luhansk Taras Shevchenko National University, Bader Svitlana , Pochynkova Mariia ,   State Institution Luhansk Taras Shevchenko National University
Published: October 2023

The article is devoted to the problem of the formation of critical thinking of an individual in the context of the value-sense paradigm of education. The authors provide a thorough description of the essence of the value-sense educational paradigm, the leading ideas of which are defined as: the natural urge of the individual to learn based on internal meanings without presenting ready-made knowledge and facts, but through meaningful learning and “discovery” of knowledge; personality is unique and unique with its own set of values and meanings, and also, in fact, personality produces values and in the educational process there is a kind of mutual exchange of values; mutual exchange of values, and, accordingly, their formation/correction is possible during subject-subject interaction between participants of the educational process, which is what the value-sense paradigm is focused on; the purpose of the educational process is to form a person’s ability to successfully model and, on this basis, realize his future based on values and meanings; the formation of the necessary competences set by society through the legal framework occurs naturally if the individual recognizes the necessary values as meaningful. In turn, the critical thinking of an individual is a type of thinking that cannot be formed in the conditions of outdated (technocratic) paradigms that are focused purely on the knowledge component. After all, critical thinking involves independent “discovery” of knowledge through analysis, reflection, generalization, revision of the formed point of view if necessary. The authors prove that the leading features of critical thinking (meaningfulness and awareness, reflexivity, purposefulness, reasonableness, self-control, independence, flexibility) can be formed only in such an educational environment that is meaningful for the individual. The implementation of the value-sense paradigm in education allows to form the critical thinking of an individual naturally, taking into account the value orientations of a person, by saturating the educational process with interactive forms and methods of work based on dialogic and partner interaction.
The role of design thinking in modern professional education: fostering innovation and problem-solving
Authors:   Kyiv National University of Technologies and Design, Pasko Oksana , Kravchenko Mariia ,   Kyiv National University of Technologies and Design
Published: October 2023

The modern development of society and technology has presented new challenges to professional education in preparing creative, innovative, and analytical professionals across various fields. In this context design thinking, which was initially employed in design professions, is gaining increasing popularity as a vital tool for developing creativity, problem-solving, and seeking innovative solutions in various professional domains. Design thinking is an innovative approach to problem-solving that is based on design principles and considers user needs. It is directed towards understanding the essence of the problem, identifying possible avenues for its resolution, fostering a creative process of idea generation, and testing solutions in practice. Design thinking extends beyond artistic aspects; it emphasizes the synthesis of knowledge from diverse fields to achieve optimal results. Empathy is one of the key elements of design thinking – the ability to sympathize and understand the needs and problems of users. This aspect is particularly crucial in professional education as it fosters the development of responsible and ethical leaders capable of designing products and services that cater to the real needs of society. Design thinking also nurtures problem-solving skills – the ability to consider a problem from different perspectives and find the most effective solutions. Integrating this approach into professional education helps students develop creative and original approaches to problem-solving, encouraging them to cultivate independent critical thinking. Another advantage of this methodology is its ability to promote teamwork by involving diverse specialists in collaborative problem-solving efforts. In the contemporary world, where complex problems demand integrated approaches, this ability is particularly valuable in professional endeavors. However, implementing design thinking into professional education faces certain challenges. Insufficient understanding of this approach and inadequate preparation of educators may impede the integration of design thinking into curricula. Additionally, existing stereotypes about design might hinder its adoption across various fields. Thus, the article focuses on the role of design thinking in modern professional education, highlighting its potential in fostering innovation and problem-solving. It analyzes the advantages of this approach and provides examples of successful implementation in various domains. It also identifies challenges that arise in the process of integrating design thinking into educational programs and proposes strategies to overcome them.
Reintegration of veterans of the hybrid war: features of measurement and characteristics of the levels of their integration
Authors:   Chernihiv Polytechnic National University, Zakharina Tetiana
Published: October 2023

The article examines the results of research into the process of reintegration of veterans of the hybrid war in the conditions of modern Ukrainian society. Special attention is focused on the characteristics of the areas of work on reintegration and the levels of implementation of interaction. Methods of measuring the effectiveness of reintegration activities are also proposed. The results of an empirical study conducted using the test methodology “WHO Quality of Life (WHOQOL) – 100” are presented, which reveals the subjective assessment of a veteran’s quality of life in various areas of its manifestation. The possibility of using diagnostic results in planning and adjusting the reintegration program is outlined. The purpose of the article is to determine and analyze the features of the social reintegration of hybrid war veterans by measuring and characterizing the levels of their integration in modern Ukrainian society. To achieve the set goal, a number of tasks were solved: an analysis of the scientific works of domestic and foreign scientists on the research problem was carried out and, based on the generalized experience, to substantiate the leading provisions of the reintegration of veterans as a social process; the conformity of the defined areas of social work with veterans to the basic needs of this category of citizens was analyzed; the components of social work with veterans of the hybrid war and the main levels of its implementation are defined and substantiated; methods of measuring the effectiveness of reintegration of veterans at different levels of implementation of activities are proposed. Implementation of the set tasks was achieved by using a complex of theoretical, practical and statistical research methods. The scientific novelty and theoretical significance of this study lies in the study of the features of measurement and characteristics of the levels of reintegration of veterans of the hybrid war in modern Ukrainian society with the help of socio-psychological diagnostic tools. The conclusions indicate that according to the basic needs of veterans, the leading directions of reintegration activities are social-legal, social-medical, social-pedagogical and psychological-social, which are implemented at the personal, institutional and state levels. The possibility of using the “WHO Quality of Life (WHOQOL) – 100” method as a diagnostic tool for the current needs of veterans and determining the directions of reintegration work has been confirmed.
Experience of Ukrainian higher education institutions in the implementation of psychological and pedagogical support for applicants with special educational needs
Authors:   State Institution Luhansk Taras Shevchenko National University, Tovstukha Olesia
Published: October 2023

The relevance of the research topic is explained by the fact that the number of applicants with special educational needs is increasing every year. This is due to the state’s social policy towards this category of applicants (clearly defined benefits), positive changes that are taking place in society regarding the integration of these individuals. The purpose of the article is analysis of the experience of organizing psychological and pedagogical support for students of higher education in Ukrainian higher education institutions. After analyzing the mechanisms for implementing psychological and pedagogical support for higher education students with educational needs, 4 higher education institutions were selected that were able to organize this process in the most qualitative and meaningful way (Pavlo Tychyna Uman State Pedagogical University, Open International University of Human Development “Ukraine”, Khmelnytsky Cooperative Institute of Trade and Economics, Poltava State Agrarian University). The main areas of work on psychological and pedagogical support for higher education students with special educational needs are: developing responsibility for their own behaviour, self-awareness and changing attitudes towards disability; counseling work with parents of students on the peculiarities of their adaptation, learning and participation in extracurricular activities on an equal footing with other participants in the educational process; social and psychological diagnostics, monitoring of personal development and social situation of students.
Patient satisfaction of specialist nurse-led renal cancer follow-up
Authors: Vanalia Parthvi , Paracha Areej , Herdman Jennifer , Zelhof Bachar
Published: October 2023

Background:

For many patients with locally advanced renal cancer, management is surgery followed by surveillance imaging for several years. There is no concrete data regarding specialist nurse follow-up for patients after they have had surgery.

Aims:

The authors' aim was to assess patient satisfaction with specialist nurse follow-up for patients with renal cancer who have undergone surgery.

Methods:

A questionnaire was used to measure patient satisfaction of the specialist nurse consultation. There were 100 patients invited who had been followed up in the nurse-led clinic between January 2020 and May 2021. These patients were given a phone call to complete the questionnaire.

Findings:

The audit revealed that in terms of general satisfaction, 97.1% of patients felt totally satisfied with their visit/consultation at the specialist nurse clinic. Furthermore, 94.2% of patients felt that they had good continuity of care with specialist nurse follow-up.

Conclusion:

Nurse-led follow-up was found to have high levels of patient satisfaction.
Attitudes of Pre-Service Teachers on the Use of 3D Printing with Tinkercad in Science Education
Authors: Güleryüz Hasan
Published: October 2023

3D printer technology and 3D design are used in many fields and are gaining various uses day by day. It is seen that the quality of education and training has increased with the effective use of 3D technology in the education and training environment. This study aims to investigate the attitudes of Pre-Service Teachers about the use of 3D printer activities made with Tinkercad in science education. 43 science pre-service teachers participated in the study, which lasted 8 weeks. A mixed research method was used in this study. The problem-solving scale and the attitude scale towards the use of 3D printers in science education were applied to the pre-service teachers. To collect the research data, the attitude scale was applied as a pre-test and post-test. For Paired samples, a t-test was applied and analyses were performed. In qualitative studies, semi-structured student interview questions were applied. According to the findings of the study, there was a significant increase in students' positive attitudes towards the use of 3D printers in science education. Tinkercad and 3D printer trainings have been given and applications have been made within the scope of these trainings. There have been 6 activities related to 3D printers. Thanks to 3D printers, students have the opportunity to present creative ideas and things they imagine to life by making designs in their minds. It seems that abstract concepts related to the sciences are embodied with a 3D printer and turned into tangible objects. Examining a physical object makes it easier for students to identify mistakes they have made in designs. It is seen that they do creative and solution-oriented work against the problems they encounter. Thus, it is predicted that learning will be more permanent and effective.
Mere Social Trinitarianism, the Eternal Relations of Origin, and Models of God
Authors: Hollingsworth Andrew
Published: October 2023

Social trinitarians are divided on whether the doctrine of the eternal relations of origin (DERO) should be maintained. In this paper, I focus on what social trinitarianism (ST) must affirm and cannot affirm by way of the divine attributes in order to maintain the DERO. First, I offer my own proposal for a mere ST before turning to the DERO, as the ST term currently suffers many uses and definitions. Second, I turn my attention to ST and the divine attributes. The DERO requires one to affirm other divine attributes of God, such as divine atemporality, divine immutability, and divine impassability. If the social trinitarian desires to maintain the DERO, then they have to maintain these other attributes. However, they will have to forgo the doctrine of divine simplicity because it is incompatible with ST. I conclude by bringing this discussion to bear on models of God and the divine attributes, arguing that the DERO-affirming social trinitarian only has one such model available to them.
Classification guided thick fog removal network for drone imaging: ClassifyCycle
Authors: Liu Yan , Qi Wenting , Huang Guan , Zhu Fubao , Xiao Yanqiu
Published: October 2023

The foggy images captured by drones are nonuniform due to inhomogeneous distribution of fog in higher altitude, leading to the obvious fog thickness differences in the images. This paper proposes a classification guided thick fog removal network for drone imaging, termed ClassifyCycle. The drone images are input into the proposed classification module (ICLFn) to enhance the reliability of follow-up learning network. The style migration module (ISMn) is introduced to reduce the image distortion, such as hue artifact and texture distort. The proposed network ClassifyCycle does not require paired foggy and corresponding fog-free datasets, avoiding the phenomena of overexposure, distortion, color deviation and fog residue after defogging. Extensive experimental results show that the proposed ClassifyCycle network surpasses the state-of-the-art algorithms on synthetic and realistic drone images captured in thick fog weather.
Optical bistability modulation based on graphene sandwich structure with topological interface modes
Authors: Li Fengyu , Xu Jiao , Li Wei , Li Jianbo , Peng Yuxiang , He Mengdong
Published: October 2023

In this paper, we have investigated optical bistability modulation of transmitted beam that can be achieved by graphene sandwich structure with topological interface modes at terahertz frequency. Graphene with strong nonlinear optical effect was combined with sandwich photonic crystal to form a new sandwich structure with topological interface modes. The light-limiting properties of the topological interface modes, as well as its high unidirectionality and high transmission efficiency, all contribute positively to the reduction of the optical bistability threshold. In addition, the topological interface modes can effectively ensure the stability of the two steady state switching in the case of external interference. Moreover, optical bistability is closely related to the incident angle, the Fermi energy, the relaxation time, and the number of layers of graphene. Through parameter optimization, optical bistability with threshold of 105 V/m can be obtained, which has reached or is close to the range of the weak field.
Thickness measurement of bimetallic film using surface plasmon resonance holographic microscopy
Authors: Mi Jingyu , Wang Chunyu , Wang Shuqi , Wang Lingke , Zhang Jiwei , Zhao Jianlin
Published: October 2023

Bimetallic film with high stability and sensitivity is often used to excite surface plasmon resonance (SPR). The thicknesses of the bimetallic film play an important role in quantitative retrieval of the sample’s parameters, and a precise measurement method is not available until now. In this paper, we propose a method for measuring the thicknesses of bimetallic film using surface plasmon resonance holographic microscopy (SPRHM). Considering that the refractive index of the dielectric upon the bimetallic film sensitively modulates the SPR phase response, the two thickness parameters of bimetallic film can be calculated by two phase-contrast SPR images with two different liquid dielectrics. The capability of this method was verified with several Ag-Au film couples by using a compact SPRHM setup. Our work provides a precise characterization method for the parameters of SPR configuration and may find wide applications in the research fields of SPR sensing and imaging.