bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic metastases in large cell neuroendocrine prostate cancer: a rare case report and literature review
Authors: Xiao Maolin , Tong Wei , Xiao Xiao , Pu Xiaofeng , Yi Faxian
Published: May 2024

Neuroendocrine prostate neoplasms, encompassing small cell carcinoma, carcinoid, and large cell carcinoma, are infrequently observed in malignant prostate tumors. The occurrence of large cell neuroendocrine prostate cancer (LCNEPC) is exceedingly rare. In this study, the patient initially presented with a persistent dysuria for a duration of one year, accompanied by a serum prostate-specific antigen (PSA) level of 17.83ng/mL. Prostate magnetic resonance imaging (MRI) and chest computed tomography (CT) scan showed that a neoplastic lesion was considered, and prostate biopsy confirmed prostate adenocarcinoma with a Gleason score of 7 (4 + 3). Then, thoracoscopic lung tumor resection was performed, and the pathological examination revealed the presence of primary moderately differentiated invasive adenocarcinoma of the lung and metastatic prostate adenocarcinoma, the Gleason score was 8 (4 + 4). After 1 year of endocrine therapy with goserelin acetate and bicalutamide, he underwent a laparoscopic radical prostatectomy (LRP), the pathological report indicated the presence of adenocarcinoma mixed with NE carcinoma. Two months after the LRP, the patient experienced gross hematuria and sacral tail pain. Further examination revealed multiple metastatic lesions throughout the body. He also underwent transurethral resection of bladder tumor (TURBT) for bladder tumor and received etoposide+ cisplatin chemotherapy three weeks post-surgery. The patient eventually died of multi-organ failure due to myelosuppression after chemotherapy. This case report presents an uncommon instance of LCNEPC with widespread systemic metastases, while also providing a comprehensive review of existing literature to facilitate improved management and treatment strategies for similar patients in subsequent cases.
Cold-evoked potentials in Fabry disease and polyneuropathy
Authors: Kersebaum Dilara , Sendel Manon , Lassen Josephine , Fabig Sophie-Charlotte , Forstenpointner Julia , Reimer Maren , Canaan-Kühl Sima , Gaedeke Jens , Rehm Stefanie , Gierthmühlen Janne , Baron Ralf , Hüllemann Philipp
Published: May 2024

Background

Fabry disease (FD) causes cold-evoked pain and impaired cold perception through small fiber damage, which also occurs in polyneuropathies (PNP) of other origins. The integrity of thinly myelinated fibers and the spinothalamic tract is assessable by cold-evoked potentials (CEPs). In this study, we aimed to assess the clinical value of CEP by investigating its associations with pain, autonomic measures, sensory loss, and neuropathic signs.

Methods

CEPs were examined at the hand and foot dorsum of patients with FD (n = 16) and PNP (n = 21) and healthy controls (n = 23). Sensory phenotyping was performed using quantitative sensory testing (QST). The painDETECT questionnaire (PDQ), FabryScan, and measures for the autonomic nervous system were applied. Group comparisons and correlation analyses were performed.

Results

CEPs of 87.5% of the FD and 85.7% of the PNP patients were eligible for statistical analysis. In all patients combined, CEP data correlated significantly with cold detection loss, PDQ items, pain, and autonomic measures. Abnormal CEP latency in FD patients was associated with an abnormal heart frequency variability item (r = −0.684; adjusted p = 0.04). In PNP patients, CEP latency correlated significantly with PDQ items, and CEP amplitude correlated with autonomic measures (r = 0.688, adjusted p = 0.008; r = 0.619, adjusted p = 0.024). Furthermore, mechanical pain thresholds differed significantly between FD (gain range) and PNP patients (loss range) (p = 0.01).

Conclusions

Abnormal CEPs were associated with current pain, neuropathic signs and symptoms, and an abnormal function of the autonomic nervous system. The latter has not been mirrored by QST parameters. Therefore, CEPs appear to deliver a wider spectrum of information on the sensory nervous system than QST alone.
Analysis of imaging in pediatric bronchopulmonary foregut malformations with literature review: case reports
Authors: Ji Shaohua , Zhang Hong , Guan Yan , Song Chen , Han Meirong
Published: May 2024

Background

Bronchopulmonary foregut malformation (BPFM) is an uncommon condition, with few case reports documented in both national and international literature. This scarcity underscores the importance of utilizing effective imaging techniques to improve our understanding and diagnostic precision concerning this disorder.

Case description

In the first case report, a neonate, born at full term and aged 15 days, presented with symptoms including dyspnea, coughing, wheezing, cyanosis, and vomiting. Initial diagnostic evaluations, which included chest radiography and upper gastrointestinal tract radiography, led to an erroneous initial diagnosis of a left-sided diaphragmatic hernia, accompanied by a suspicion of infection. In the second case report, another neonate, also born at full term but aged 5 days, exhibited symptoms such as coughing, choking, and mild vomiting. Utilizing a combination of computed tomography (CT) scans (plain, enhanced, and reconstructed), chest x-ray, and upper gastrointestinal tract radiography, the diagnosis of BPFM was accurately determined.

Conclusion

Comprehensive imaging examinations play a crucial role in reducing misdiagnosis and diagnostic oversights in cases of BPFM. Given its rarity, BPFM often manifests as a sequestered lung accompanied by gastrointestinal abnormalities. Hence, the integration of CT scans with gastrointestinal tract radiography can substantially improve diagnostic precision in such cases.
Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4
Authors: Albadry Mohamed , Küttner Jonas , Grzegorzewski Jan , Dirsch Olaf , Kindler Eva , Klopfleisch Robert , Liska Vaclav , Moulisova Vladimira , Nickel Sandra , Palek Richard , Rosendorf Jachym , Saalfeld Sylvia , Settmacher Utz , Tautenhahn Hans-Michael , König Matthias , Dahmen Uta
Published: May 2024

There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap essential for translational studies. This study investigated the critical interplay between lobular geometry and key cytochrome P450 (CYP) zonation in four species: mouse, rat, pig, and human. We developed an automated pipeline based on whole slide images (WSI) of hematoxylin-eosin-stained liver sections and immunohistochemistry. This pipeline allows accurate quantification of both lobular geometry and zonation patterns of essential CYP proteins. Our analysis of CYP zonal expression shows that all CYP enzymes (besides CYP2D6 with panlobular expression) were observed in the pericentral region in all species, but with distinct differences. Comparison of normalized gradient intensity shows a high similarity between mice and humans, followed by rats. Specifically, CYP1A2 was expressed throughout the pericentral region in mice and humans, whereas it was restricted to a narrow pericentral rim in rats and showed a panlobular pattern in pigs. Similarly, CYP3A4 is present in the pericentral region, but its extent varies considerably in rats and appears panlobular in pigs. CYP2D6 zonal expression consistently shows a panlobular pattern in all species, although the intensity varies. CYP2E1 zonal expression covered the entire pericentral region with extension into the midzone in all four species, suggesting its potential for further cross-species analysis. Analysis of lobular geometry revealed an increase in lobular size with increasing species size, whereas lobular compactness was similar. Based on our results, zonated CYP expression in mice is most similar to humans. Therefore, mice appear to be the most appropriate species for drug metabolism studies unless larger species are required for other purposes, e.g., surgical reasons. CYP selection should be based on species, with CYP2E1 and CYP2D6 being the most preferable to compare four species. CYP1A2 could be considered as an additional CYP for rodent versus human comparisons, and CYP3A4 for mouse/human comparisons. In conclusion, our image analysis pipeline together with suggestions for species and CYP selection can serve to improve future cross-species and translational drug metabolism studies.
Low-sampling high-quality Hadamard and Fourier single-pixel imaging through automated optimization neural network
Authors: Lei Guozhong , Lai Wenchang , Meng Qi , Cui Wenda , Liu Hao , Wang Yan , Han Kai
Published: May 2024

In this manuscript, an automated optimization neural network is applied in Hadamard single-pixel imaging (H-SPI) and Fourier single-pixel imaging (F-SPI) to improve the imaging quality at low sampling ratios which is called AO-Net. By projecting Hadamard or Fourier basis illumination light fields onto the object, a single-pixel detector is used to collect the reflected light intensities from object. The one-dimensional detection values are fed into the designed AO-Net, and the network can automatically optimize. Finally, high-quality images are output through multiple iterations without pre-training and datasets. Numerical simulations and experiments demonstrate that AO-Net outperforms other existing widespread methods for both binary and grayscale images at low sampling ratios. Specially, the Structure Similarity Index Measure value of the binary reconstructed image can reach more than 0.95 when the sampling ratio is less than 3%. Therefore, AO-Net holds great potential for applications in the fields of complex environment imaging and moving object imaging.
Redefining awn development in rice through the breeding history of Japanese awn reduction
Authors: Suganami Mao , Yoshida Hideki , Yoshida Shinya , Kawamura Mayuko , Koketsu Eriko , Matsuoka Makoto , Kojima Soichi
Published: May 2024

The study challenges the conventional understanding of awn loss as a domestication syndrome, showing instead that many awned varieties continued to be widely grown in Japan until the early twentieth century and that selection for awn reduction was active at that time, demonstrating that awn loss is not a domestication syndrome but “a trait that emerged during crop improvement”. Although selection for awnless mutants was carried out independently using different types of awned cultivars in the early twentieth century in Japan, awn loss was caused by the mutation in OsEPFL1. This suggests that a single mutant haplotype of OsEPFL1 was conserved in the genomes of different cultivars and subsequently selected within each line to meet the demand for awnless varieties. The study also conducts phylogenetic analyses of EPFL1 in 48 grass plants, revealing its unique involvement in awn formation in rice while potentially playing a different role in the domestication of other grass plants. Finally, an attempt is made to isolate an awn-forming gene that has not been identified from the awned rice cultivar “Omachi”, which is still cultivated in Japan. The results presented in this paper provide a new perspective on domestication against the conventional understanding of awn development, shedding light on its potential as a useful organ for breeding to mitigate environmental stress.
Increase in potato yield by the combined application of biochar and organic fertilizer: key role of rhizosphere microbial diversity
Authors: Hou Jianwei , Xing CunFang , Zhang Jun , Wang Zuhua , Liu Min , Duan Yu , Zhao Hui
Published: May 2024

Purpose

The large-scale planting of potatoes leads to soil degradation, thus limiting the potato yield. An effective method of improving soil quality involves the combined application of biochar and organic fertilizer. However, the proportion of biochar and organic fertilizer at which potato yield can be improved, as well as the improvement mechanism, remain unclear.

Methods

A combined application experiment involving biochar (B) and organic fertilizer (O) with four concentration gradients was conducted using the equal carbon ratio method. On this basis, rhizosphere soil fertility, bacterial community composition, and bacterial diversity in potato crops, as well as the potato yield difference under different combined application ratios, were investigated. Then, the direct and indirect effects of these factors on potato yield were analyzed.

Results

The results suggest that soil fertility was improved by the combined application of biochar and organic fertilizer, with the best effect being achieved at a ratio of B:O=1:2. The dominant bacterial communities in the potato rhizosphere included Proteobacteria, Actinobacteria, Gemmatimonadetes, Chloroflexi, and Bacteroidetes. When compared to the control, the relative abundance and diversity index of soil bacteria were significantly improved by the treatment at B:O=1:2, which exerted a stronger effect on improving the relative abundance of beneficial bacteria. Soil available phosphorus (AP), soil pH (SpH), and soil organic carbon (SOC) explained 47.52% of the variation in bacterial composition. Among them, the main factor was the content of soil available nutrients, while SpH generated the weakest effect. The bacterial diversity index showed a significant positive correlation with soil AP, SOC, available potassium (AK), total nitrogen (TN), and C/N ratio, and a significant negative correlation with SpH. Bacterial diversity directly affected the potato yield, while soil fertility indirectly affected potato yield by influencing the soil bacterial diversity.

Conclusion

The combined application of biochar and organic fertilizer elevates potato yield mainly by improving the diversity of bacterial communities in potato rhizosphere soil, especially the combined application of biochar and organic fertilizer at a 1:2 ratio (biochar 0.66 t ha-1+organic fertilizer 4.46 t ha-1), which made the largest contribution to increasing potato yield.
Woody encroachment induced earlier and extended growing season in boreal wetland ecosystems
Authors: Sun Hongchao , Wang Wen J. , Liu Zhihua , Wang Lei , Bao Suri G. , Ba Shengjie , Cong Yu
Published: May 2024

Woody plant encroachment (WPE), a widespread ecological phenomenon globally, has significant impacts on ecosystem structure and functions. However, little is known about how WPE affects phenology in wetland ecosystems of middle and high latitudes. Here, we investigated the regional-scale effects of WPE on the start (SOS), peak (POS), end (EOS), and length (GSL) of the growing season in boreal wetland ecosystems, and their underlying mechanisms, using remote sensing dataset during 2001–2016. Our results showed that WPE advanced the annual SOS and POS, while delaying EOS and extending GSL in boreal wetlands with these impacts increasing over time. When boreal wetland ecosystems were fully encroached by woody plants, the SOS and POS were advanced by 12.17 and 5.65 days, respectively, the EOS was postponed by 2.74 days, and the GSL was extended by 15.21 days. We also found that the impacts of WPE on wetland SOS were predominantly attributed to the increased degree of WPE (α), while climatic factors played a more significant role in controlling the POS and EOS responses to WPE. Climate change not only directly influenced phenological responses of wetlands to WPE but also exerted indirect effects by regulating soil moisture and α. Winter precipitation and spring temperature primarily determined the effects of WPE on SOS, while its impacts on POS were mainly controlled by winter precipitation, summer temperature, and precipitation, and the effects on EOS were mainly determined by winter precipitation, summer temperature, and autumn temperature. Our findings offer new insights into the understanding of the interaction between WPE and wetland ecosystems, emphasizing the significance of considering WPE effects to ensure accurate assessments of phenology changes.
Decomposing the variance in early maladaptive schemas: the major role of one general factor, the minor role of domains, and their differential relations to facial emotion recognition
Authors: Tabesh Sajedeh , Zia-Tohidi Ali , Firoozi Manijeh , Farahani Hojjatollah
Published: May 2024

Introduction

Despite the growing interest in the early maladaptive schemas, the progress in understanding their impacts is decelerated by a lack of clear understanding of their structure. Different composite scores are calculated without a solid ground or a clarified meaning. Here we explain that the schema variance can be theoretically decomposed into three components: schema-specific, domain-specific due to the unmet core needs, and the common variance we call general susceptibility; each can differentially correlate with other substantive variables. Using this framework, we empirically examine the structure of schemas and their relationships to facial emotion recognition, a crucial ability that can widely affect our social interactions.

Methods

A sample of adults completed an emotion recognition task and the Young Schema Questionnaire. Using different factor models, the specific and shared variance across schemas was analyzed. Then, the relation of these variance components to facial emotion recognition was explored.

Results

A general factor explained 27%, 40%, and 64% of the total variance in items, schemas, and domains, respectively. Partialling out the common variance, there was little domain-specific variance remained. Regarding facial emotion recognition, they were not correlated with specific schemas; however, the general susceptibility factor was correlated with anger recognition.

Discussion

The variance decomposition approach to schemas, which uses the bifactor model, may offer a clearer way to explore the impacts of schemas. While domain scores are widely used, their reliability, validity, and meaning are questionable. The generic factor, which is consistently extractable from empirical data, requires further attention.
A comprehensive study of the academic benefits and practical recommendations to include resistance training programs in institutional education
Authors: Fraile-Martinez Oscar , García-Montero Cielo , Fraile-Martinez Marcos , Pekarek Leonel , Barrena-Blázquez Silvestra , López-González Laura , Álvarez-Mon Miguel Ángel , Pekarek Tatiana , Casanova Carlos , Álvarez-Mon Melchor , Diaz Raul , Saez Miguel A. , Ortega Miguel A.
Published: May 2024

The connection between physical activity and cognitive function has become a focus of attention in educational research in recent years. Regular exercise has been shown to have significant positive effects on physical health, but it also appears to have a significant impact on cognitive function and academic performance. Of all the exercise modalities, resistance training has drawn interest for its ability to improve cerebral abilities in addition to physical well-being. However, there is limited available knowledge exploring the relationship between resistance training regimens and academic performance. This narrative review aims to investigate the underlying mechanisms linking resistance training to academic performance. Firstly, we will examine the biological mechanisms and psychosocial links that potentially connect resistance training to academic performance to find and describe the different mechanisms by which resistance training improves academic performance. In the next part of the work, we delve into the existing observational and intervention studies that have explored the relationship between resistance training and academic performance. Lastly, we provide practical recommendations for including resistance training in institutional education settings, emphasizing the need of dispelling myths and addressing barriers to increase participation as well as the relevance of considering key training variables and adaptation of protocols to developmental stages, always guided by a properly trained professional. Overall, the available evidence supports that resistance training provides potential benefits to the academic performance of youth students with many biological and psychosocial factors that explain this relationship. However, most of the studies are observational, and broader interventional studies are needed to understand and maximize the benefits of this type of physical exercise.
Effects of coach-delivered verbal encouragement on the physiological and psychological responses of adolescent players in small-sided basketball games
Authors: Khayati Ala , Sahli Faten , Ghouili Hatem , Labbadi Rabeh , Selmi Okba , Sahli Hajer , Jebabli Nidhal , Romdhani Amir , Zghibi Makram , Haddad Monoem
Published: May 2024

Introduction

The confluence of physiological and psychological dynamics is fundamental to athletic performance, particularly in basketball, where physical skill and mental resilience are imperative. While the role of verbal encouragement (VE) as a catalyst for enhancing performance has been explored in various sports disciplines, its specific effects within the basketball have not been adequately examined. Addressing this gap, the current study zeroes in on the influence of coach-delivered VE on the physiological and psychological responses of adolescent basketball players engaged in small-sided games (SSG), providing a focused analysis of how directed encouragement can modulate performance and experience in young athletes. This study aimed to investigate the effects of coach-delivered verbal encouragement on the psychological and physiological responses of adolescent basketball players.

Methods

Sixteen male participants (age: 16.93 ± 0.36 years; height: 176.8 ± 0.8 cm; body mass: 73.43 ± 12.57 kg; BMI: 21.70 ± 3.55) were allocated to a Verbal Encouragement Group (VEG, n = 8, mean age: 16.80 ± 0.44) and a Control Group (CG, n = 8, mean age: 17.06 ± 0.26). Each participant engaged in four sessions of small-sided games (SSGs) consisting of four players per side in a 14 × 10 m pitch.

Results

The findings revealed significant benefits of coach-delivered verbal encouragement on both the physical and psychophysiological responses of the players (p < 0.05), including increased physical enjoyment, positive mood state, lower heart rate, and higher physical activity intensity level.

Discussion

Coaches should incorporate verbal encouragement strategies during SSGs to enhance player performance and optimize both psychological and physiological adaptations.
Who spoke that language? Assessing early face-language associations in monolingual and bilingual infants
Authors: Marcet Laia , Birulés Joan , Bosch Laura , Pons Ferran
Published: May 2024

Introduction

In bilingual communities, knowing the language each speaker uses may support language separation and, later, guide language use in a context-appropriate manner. Previous research has shown that infants begin to form primary associations between the face and the language used by a speaker around the age of 3 months. However, there is still a limited understanding of how robust these associations are and whether they are influenced by the linguistic background of the infant. To answer these questions, this study explores monolingual and bilingual infants’ ability to form face-language associations throughout the first year of life.

Methods

A group of 4-, 6-, and 10-month-old Spanish and/or Catalan monolingual and bilingual infants were tested in an eye-tracking preferential-looking paradigm (N = 156). After the infants were familiarized with videos of a Catalan and a Spanish speaker, they were tested in two types of test trials with different task demands. First, a Silent test trial assessed primary face-language associations by measuring infants’ visual preference for the speakers based on the language they had previously used. Then, two Language test trials assessed more robust face-language associations by measuring infants’ ability to match the face of each speaker with their corresponding language.

Results

When measuring primary face-language associations, both monolingual and bilingual infants exhibited language-based preferences according to their specific exposure to the languages. Interestingly, this preference varied with age, with a transition from an initial familiarity preference to a novelty preference in older infants. Four-month-old infants showed a preference for the speaker who used their native/dominant language, while 10-month-old infants preferred the speaker who used their non-native/non-dominant language. When measuring more robust face-language associations, infants did not demonstrate signs of consistently matching the faces of the speakers with the language they had previously used, regardless of age or linguistic background.

Discussion

Overall, the results indicate that while both monolingual and bilingual infants before the first year of life can form primary face-language associations, these associations remain fragile as infants seemed unable to maintain them when tested in a more demanding task.
Bolstering the adaptive information processing model: a narrative review
Authors: Rydberg Jenny Ann , Virgitti Lisa , Tarquinio Cyril
Published: May 2024

In recent years, several theoretical models have been suggested as complementary to the adaptative information processing model of eye movement desensitization and reprocessing therapy. A narrative review of such models was conducted to assess the contributions of each, as well as their convergences, contradictions, and potential complementarity. Seven theoretical models were identified. All focus on the effects of EMDR therapy as a comprehensive psychotherapy approach with its principles, procedures, and protocols. Several refer to concepts related to propositional or predictive processing theories. Overall, the contribution of these proposals does appear to bolster Shapiro’s original AIP model, potentially offering additional depth and breadth to case conceptualization and treatment planning in clinical practice, as well as a more precise theoretical understanding. The current exploratory comparative analysis may serve as a preliminary baseline to guide research into the relative merit of suggested theoretical proposals to enhance current standards for the clinical practice and teaching of EMDR therapy.
Move for Life an intervention for inactive adults aged 50 years and older: a cluster randomised feasibility trial
Authors: Woods Catherine B. , O’Regan Andrew , Doyle Ciaran , Hayes Grainne , Clifford Amanda , Donnelly Alan E. , Gillespie Paddy , Glynn Liam , Murphy Andrew W. , Sheikhi Ali , Bengoechea Enrique García
Published: May 2024

Background

Move for Life (MFL) is a theory-informed intervention that was developed to augment established physical activity (PA) programmes and enable inactive adults aged 50 years and older to be more active. This study examined the feasibility of MFL and sought to provide evidence of its potential for improving PA and associated health outcomes.

Methods

A 3-arm cluster randomised feasibility trial compared MFL intervention, usual provision (UP) and control (CON) groups at baseline (T0), post-intervention (T1, at 8, 10 or 12- weeks) and 6-month follow up (T2). We used purposive sampling strategies to recruit participants according to characteristics of interest. Feasibility outcomes assessed recruitment, fidelity, adherence, retention and data completion rates based on pre-set criteria. Primary outcomes were accelerometer-based moderate-to-vigorous intensity PA (MVPA) and self-reported compliance with physical activity guidelines (PAGL). Secondary outcomes included light intensity PA (LiPA), standing time, sedentary time, body composition (adiposity), physical function and psychological well-being. We used linear mixed models (continuous outcomes) or generalized estimated equations (categorical outcomes) to estimate group differences over time in the study outcomes.

Results

Progression criteria for feasibility outcomes were met, and 733 individuals were recruited. Considering a 6-month period (T0-T2), while self-reported compliance with PAGL increased in MFL relative to UP and CON and in UP relative to CON, standing time decreased in MFL relative to CON and sedentary time increased in the latter compared to UP. Waist circumference decreased in MFL relative to UP and CON. MFL outperformed UP in the Timed Up and Go Test while MFL and UP increased the distance covered in the Six-Minute Walk Test compared to CON. Psychological well-being increased in MFL relative to CON (all p < 0.05).

Conclusion

Findings show that MFL is feasible, while data are promising with regards to the potential of improving community PA programmes for adults aged 50 or more years.

Clinical trial registration

https://www.isrctn.com/Registration#ISRCTN11235176.
Congenital cytomegalovirus in Sub-Saharan Africa—a narrative review with practice recommendations
Authors: Payne Helen , Barnabas Shaun
Published: May 2024

Cytomegalovirus (CMV) is the most common cause of congenital infection internationally, occurring in 0.67% of births, and increasingly recognised as a major public health burden due to the potential for long-term neurodevelopmental and hearing impairment. This burden includes estimates of 10% of childhood cerebral palsy and up to 25% of childhood deafness. In Sub-Saharan Africa, where CMV-seroprevalence is almost ubiquitous, prevalence of congenital CMV (cCMV) is higher than the global average, and yet there is a dearth of research and initiatives to improve recognition, diagnosis and treatment. This narrative review outlines the epidemiology and clinical presentation of cCMV, discusses issues of case identification and treatment in Sub-Saharan Africa, and recommends a framework of strategies to address these challenges. Considering the significant burden of cCMV disease in this setting, it is undoubtably time we embark upon improving diagnosis and care for these infants.
Multilevel analysis of discrimination of people living with HIV/AIDS and associated factors in Ghana: demographic health survey of 2022 Ghana data
Authors: Melkam Mamaru , Fente Bezawit Melak
Published: May 2024

Introduction

The negative effects of stigma and discrimination in communities and families include medication non-adherence, heightened psychological distress, verbal and physical abuse, a lack of social support, isolation, and dangerous health behaviors such as hiding prescriptions. Despite the huge burden of HIV/AIDS discriminatory attitudes, limited studies were conducted in Ghana. Therefore, this study examines the burden of discriminatory attitudes and their determinant factors on people who are living with HIV/AIDS in Ghana.

Objective

This study aimed to determine the prevalence of discriminatory attitudes and associated factors among people who are living with HIV/AIDS in Ghana based on recent DHS data.

Method

Secondary data analysis was used for this multilevel logistic regression analysis based on the Ghana Demographic Health Survey of 2022. Data extraction, cleaning, and analysis were conducted using Stata version 14. The community of Ghana, from the 15 to 49 age group, was used for this study, with a final sample size of 22,058 participants. Four separate models were fitted, incorporating individual and community levels. Multilevel logistic regression models were calibrated to determine the associated factors at the individual and community level with discriminatory attitudes, with a 95% CI and AOR.

Results

The prevalence of discriminatory attitudes toward people living with HIV/AIDS was 60.92%, with a 95% CI (60.13, 61.70) among Ghana DHS. Lower wealth status, having no comprehensive knowledge of HIV, low educational status at the individual level, and low wealth status at the community level, poorest and poorer [AOR =2.03; 95% CI: (1.04, 3.94)] and [AOR = 2.09; 95% CI: (1.84, 8.65)], respectively, no comprehensive knowledge [AOR = 3.42; 95% CI: (1.74, 6.73)], no and primary education [AOR = 3.18; 95% CI: (2.48, 5.51)] and [AOR = 3.78; 95% CI: (2.68, 5.92)], respectively, at the individual level and low wealth status [AOR = 1.58; 95% CI: (1.00, 2.46)] community level were the associated factors.

Conclusion

The prevalence of discriminatory attitudes toward people living with HIV/AIDS was high (60.92%) in Ghana’s DHS. The associated factors for this study were lower wealth status, having no comprehensive knowledge of HIV, and low educational status at the individual level.
Affiliative nomads in Japan: potential sustainable tourism stakeholders in depopulated rural areas
Authors: Horiuchi Shiro , Morishige Masayuki
Published: May 2024

In Japan, the overall population is declining. Depopulation is severe, resulting in various negative consequences, particularly in rural areas. Rural communities could benefit by collaborating with people from other places, mainly urban areas. Typical examples of visitors or tourists from urban areas in these cases are referred to as “kankei jinko.” The more fundamental issue, however, is that many rural residents have lost confidence in their ability to live in areas with declining and aging populations. It is important to note the potential for highly mobile people from urban areas to increase the civic pride of rural residents. This raises questions about who these nomadic people, or “affiliative nomads,” are and how they interact with residents. To answer these questions, we analyzed cases of affiliative nomads in previous studies. The nomadic people showed respect for the rural areas to the residents; as a result, they were perceived by the residents as being in a stage of growth. When the nomads and residents interact, they create common values such as nature conservation and economic and community revitalization. Thus, the nomads cultivate civic pride among the residents and could be regarded as affiliative nomads. Furthermore, some coordinators bridge residents and nomads to expand their relationships with other people. Affiliative nomads may be sustainable tourism stakeholders and contribute to solving the problems of depopulated areas in Japan and other developed or emerging countries.
Facebook reactions in the context of politics and social issues: a systematic literature review
Authors: Anwar Sawood , Giglietto Fabio
Published: May 2024

In February 2016, Facebook expanded the original “Like” button by introducing five additional “Reactions”—Love, Haha, Wow, Sad, and Angry—using modified versions of Unicode emojis. These reactions enable users to express more nuanced emotions towards posts. This literature review investigates scholarly research on user behavior in response to these reactions, with a focus on a broad spectrum of socioeconomic and psychological issues. We conducted a systematic search across databases including Scopus and Google Scholar, using keywords such as “Facebook” and “Reaction,” combined with various key phrases and Boolean operators. Our review synthesizes sixty-four articles published from 2016 to 2023, exploring diverse topics such as political news, far-right and extremist parties, racism, and hate speech during the COVID-19 pandemic. We organized these articles by theme and publication date. Our meta-analysis reveals that lifestyle and entertainment posts predominantly receive positive reactions, while sociopolitical content tends to elicit a broader spectrum of emotions, including negative sentiments. Furthermore, emotionally charged content consistently attracts higher volumes of reactions, regardless of sentiment. This research highlights the intricate relationship between user reactions and content characteristics, providing deeper insights into the dynamics of online engagement. By understanding these interaction patterns, we gain a better grasp of emotional responses and engagement levels, which ultimately shape online discourse and user interactions.
Computed tomographic heterogeneous enhancement of spleen in healthy cats: comparing with diffuse infiltrative splenic lesions
Authors: Lee Yooyoung , Chang Dongwoo , Kim Sojin , Oh Miju , Ban Jiyoung , Lee Minju , Chang Jinhwa , Ahn Jisoo , An Taegeon
Published: May 2024

Introduction

Contrast-enhanced computed tomography (CT) of the spleen in dogs and cats often displays a heterogeneous enhancement pattern. This study aimed to describe the CT appearances and duration of heterogeneous splenic enhancement in clinically healthy cats and to compare those enhancements with diffuse infiltrative splenic lesions (DISL).

Methods

Spleens of 14 healthy cats were imaged using contrast-enhanced CT protocols which were obtained at 10, 25, and 45 s, and then every 40 s thereafter until 245 s had past from the initiation of contrast medium injection. The presence of transient splenic heterogeneity was evaluated. In addition, the relationships of certain variables including age, weight, systolic blood pressure, and splenic volume to the duration and the degree of splenic enhancement were determined. Also, medical records and CT images of five cats with DISL were retrospectively evaluated.

Result

Transient heterogeneous enhancement of the spleen was observed in all 14 healthy cats, and the maximum heterogeneity was observed 25 s after the injection. Splenic heterogeneity lasted more than 5 min in nine of 14 cats (64.3%). No statistically significant relationships were seen between the duration and degree of splenic heterogeneity in the images taken 25 s after the injection and variables including weight, age, systolic blood pressure, and splenic volume.

Discussion

Compared to the healthy group, early homogeneous splenic enhancement along with generalized splenomegaly was observed in all cats with DISL. Transient splenic heterogeneity is highly common in cats undergoing contrast-enhanced CT even in the generally scanned delayed phases, which can help with the interpretation of CT images of feline spleens. In addition, our results suggest that homogeneous splenic enhancement in post-contrast CT scans along with splenomegaly on CT images could be useful as a diagnostic indicator of DISL in cats.
Sequential Optimal Trajectory Planning Scheme for Robotic Manipulators along Specified Path Based on Direct Collocation Method
Authors: Xiong Ziyao , Ding Jianwan , Chen Liping , Chen Yu , Yan Dong
Published: May 2024

Robotic manipulators play a pivotal role in modern intelligent manufacturing and unmanned production systems, often tasked with executing specific paths accurately. However, the input of the robotic manipulators is trajectory which is a path with time information. The resulting core technology is trajectory planning methods which are broadly classified into two categories: maximum velocity curve (MVC) methods and multiphase direct collocation (MPDC) methods. This paper concentrates on addressing challenges associated with the latter methods. In MPDC methods, the solving efficiency and accuracy are greatly influenced by the number of discretization nodes. When dealing with systems with complex dynamics, such as robotic manipulators, striking a balance between solving time and path discretization errors becomes crucial. We use a mesh refinement (MR) algorithm to find a suitable number of nodes under the premise of ensuring the path discretization error. So, the actual device can effectively implement the planned solutions. Nonetheless, the conventional application of the MR algorithm requires solving the original problem in each iteration; these processes are extremely time-consuming and may fail to solve when dealing with a complex dynamic system. As a result, we propose a sequential optimal trajectory planning scheme to solve the problem efficiently by dividing the original optimal control (OC) problem into two stages: path planning (PP) and trajectory planning (TP). In the PP stage, we employ a DC method based on arc length and an MR algorithm to identify key nodes along the specified path. This aims to minimize the approximation error introduced during discretization. In the TP stage, the identified key nodes serve as boundary conditions for an MPDC method based on time. This facilitates the generation of an optimal trajectory that maximizes motion performance, considering constant velocity in Cartesian space and dynamic constraints while keeping the path discretization error. Simulation and experiment are conducted with a six-axis robotic manipulator, ROCR6, and show significant potential for a wide range of applications in robotics.
Research on Multi-Mode Control of Electro-Hydraulic Variable Displacement Pump Driven by Servo Motor
Authors: Zhang Zhiqiang , Yan Yupeng , Li Lin , Chao Qun , Jin Kunshan , Liu Zhiqi
Published: May 2024

The electro-hydraulic power source with an electro-hydraulic variable pump driven by a servo motor is suitable for electrified construction machinery. To achieve better energy efficiency in different working conditions, the multi-mode control scheme was proposed for the electro-hydraulic power source. The control scheme includes pressure control, flow control, and torque control modes. The switching rule among the three control modes was formulated based on the minimum pump pressure. The fuzzy PID controller was designed, and a composite flow regulation strategy was formulated, including the load-sensitive adaptive displacement regulation and servo motor variable speed regulation. The AMESim-Simulink co-simulation model of multi-mode control was established. The test platform was built, and the experimental study was carried out. The results indicate that the fuzzy PID control has a shorter response time and a more stable control effect compared with PID control. Additionally, the composite flow regulation strategy improves the flow regulation range by 36% and reduces the flow overshoot by 20% compared with the load-sensitive adaptive displacement regulation. As the main control valve received an opening step signal, the full flow regulation (7~81 L/min) of the power source took approximately 0.5 s to rise and 0.2 s to fall. The relative error of pressure difference for the main control valve was 0.63%. When receiving the pressure and torque step signal, the pump pressure and pump input torque both took approximately 0.45 s to rise and 0.2 s to fall. The relative errors of pump pressure and torque control were 0.2% and 0.16%, respectively. In the multi-mode control, the electro-hydraulic power source could switch smoothly between flow control mode, pressure control mode, and torque control mode. These results provide a reference for the multi-mode control of an electro-hydraulic power source with an electro-hydraulic variable pump driven by a servo motor.
Rolling Mechanism of Launch Vehicle during the Prelaunch Phase in Sea Launch
Authors: Wang Deng , Xiao Wenhao , Shao Jianshuai , Li Mingjun , Zhao Yuanyang , Jiang Yi
Published: May 2024

During the sea launch of a launch vehicle in low sea state, a rolling phenomenon of the launch vehicle has been observed. In rough sea conditions, launch may failure. This study utilizes dimensionality reduction-driven spatial system projection methods and virtual prototype modeling technology to reveal that the launch vehicle’s rolling is caused by differences in the motion paths of the center of mass. Additionally, during the prelaunch stage, the variation in the trajectory of the launch vehicle’s center of mass caused by the rolling and pitching motions of the transportation vessel has a significant impact on the roll motion of the launch vehicle. The motion in other degrees of freedom has minimal influence on the launch vehicle’s rolling. The minimum rocket rolling occurs when the dynamic coefficient of friction of the launchpad–launch vehicle contact is 0.05, and the dynamic coefficient of friction of the adapters and guideways is 0.4. The conclusions provide a theoretical foundation for optimizing the sea launch system and enhancing the reliability of sea launch in rough sea conditions.
Temperature Prediction of Icy Lunar Soil Sampling Based on the Discrete Element Method
Authors: Zhao Deming , Peng Tianyi , Zhang Weiwei , Wang He , Cui Jinsheng
Published: May 2024

This study is part of the preliminary research for the Chang’e 7 project in China. The Chang’e 7 project plans to drill to penetrate the lunar polar soil and collect lunar soil samples using a spiral groove structure. Ice in the cold environment of the lunar polar region is one of the important targets for sampling. In the vacuum environment of the lunar surface, icy soil samples are sensitive to ambient temperature and prone to solid–gas phase change as the temperature increases. To predict the temperature range of lunar soil samples, this study analyzed the effect of thermal parameters on the temperature rise of lunar soil particles and the drill using discrete element simulation. The parameters included in the thermal effect analysis included the thermal conductivity and specific heat capacity of the drilling tools and lunar soil particles. The simulation showed that the temperature of the icy lunar soil sample in the spiral groove ranged from −127.89 to −160.16 °C within the thermal parameter settings. The magnitude of the value was negatively correlated with the thermal conductivity and specific heat capacity of the lunar soil particles, and it was positively correlated with those of the drilling tools. The temperature variation in the drill bit ranged from −51.21 to −132 °C. The magnitude of the value was positively correlated with the thermal conductivity and specific heat capacity of the lunar soil particles and the thermal conductivity of the drilling tool.
Characterization of the Endwall Flow in a Low-Pressure Turbine Cascade Perturbed by Periodically Incoming Wakes, Part 2: Unsteady Blade Surface Measurements Using Pressure-Sensitive Paint
Authors: Schubert Tobias , Kožulović Dragan , Bitter Martin
Published: May 2024

Unsteady pressure-sensitive paint (i-PSP) measurements were performed at a sampling rate of 30 kHz to investigate the near-endwall blade suction surface flow inside a low-pressure turbine cascade operating at engine-relevant high-speed and low-Re conditions. The investigation focuses on the interaction of periodically incoming bar wakes at 500 Hz with the secondary flow and the blade suction surface. The results build on extensive PIV measurements presented in the first part of this two-part publication, which captured the ’negative-jet-effect’ of the wakes throughout the blade passage. The surface pressure distributions are combined with CFD to analyze the flow topology, such as the passage vortex separation line. By analyzing data from phase-locked PIV and PSP measurements, a wake-induced moving pressure gradient negative in space and positive in time is found, which is intensified in the secondary flow region by 33% with respect to midspan. Furthermore, two methods of frequency-filtering based on FFT and SPOD are compared and utilized to associate a pressure fluctuation peak around 678 Hz with separation bubble oscillation.
Interactions between Root Hair Development and Arbuscular Mycorrhizal Fungal Colonization in Trifoliate Orange Seedlings in Response to P Levels
Authors: Cao Xiu , Zhao Yu , Xia Ren-Xue , Wu Qiang-Sheng , Hashem Abeer , Abd_Allah Elsayed Fathi
Published: May 2024

Both arbuscular mycorrhizal (AM) fungi and root hairs are crucial in facilitating plant uptake of phosphorus (P), while it is unclear whether and how they respond to varying P supplies. In order to explore how AM fungal colonization and root hair development are affected by substrate P supply, trifoliate orange (Poncirus trifoliata) seedlings were inoculated with AM fungus Rhizophagus intraradices and grown under low, moderate, and high P conditions; then, root hair morphological features and AM fungal colonization were measured. Following 120 days of AM fungal inoculation, root hair density, root hair length, AM fungal colonization rate, arbuscule colonization rate, and AM fungal colonization frequency all increased significantly under P-deficient conditions but decreased under high P conditions. Moreover, the colonization of AM fungi had a major impact on root hair formation by altering the expression of related genes and the growth of epidermal cells. The effect of AM fungi was dependent on P supply levels, as evidenced by the fact that root hair density and length increased at high P levels but decreased at low P levels. As a result, root hairs may serve as a preferential site for AM fungal colonization, and their morphology could influence the early stage of AM symbiosis establishment.