bluuebunny/crossref_metadata_2025 huggingface dataset:
Eosinophilic esophagitis
Authors: Watts Melissa M. , Saltoun Carol , Greenberger Paul A.
Published: November 2019

Eosinophilic esophagitis (EoE) is defined by symptoms related to esophageal dysfunction, persistent esophageal eosinophilia, and exclusion of other etiologies that may be contributing to the condition. EoE is different from erosive esophagitis. In children, symptoms vary by age groups,
such as feeding disorders in 2 year olds; vomiting in 8 year olds; and abdominal pain, dysphagia, and/or food impaction in adolescents. Most adults present with dysphagia, food impaction, heartburn, or chest pain. Common endoscopic features in adults with EoE include linear furrows (creases
that orient longitudinally), mucosal rings (esophageal “trachealization”), small-caliber esophagus, white plaques or exudates (which are microabscesses of eosinophils), and strictures. Children often present with similar endoscopic features, yet one-third of pediatric patients
with EoE have a normal result in an endoscopic examination. Histologic features of EoE include increased intramucosal eosinophils in the esophagus (≥15 eosinophils per high power field), without similar findings in the stomach or duodenum. There also may be eosinophilic microabscesses.
In addition to evidence of mast cell activation, mucosa from patients with EoE have increased levels of interleukin 5; supporting eosinophilia; and upregulation of gene expression of eotaxin-3, a chemokine important in eosinophil migration. The majority of patients have evidence of either
aeroallergen and/or food sensitization. Dietary therapy is considered first-line therapy for patients with EoE because it is inexpensive and effective, without requiring pharmacologic therapy. Removal of food antigens has been shown to improve symptoms in patients with EoE. Topical corticosteroids
improve esophageal eosinophilia and symptoms, and have become the criterion standard of pharmacotherapy.
Design Chart of a footing located on a Crest of the Unsaturated Soil slopes
Authors: Khattab Suhail A. A. , Al-Sulaifanie Bayer J. , Mohammed Rabi' A.
Published: November 2019

A parametric study points out the effect of various influential parameters on the stability of the unsaturated clayey and alluvial soil slopes using finite element computer programs of GEOSLOPE. The rainfall intensity and duration is considered as one of the studied parameters, three intensity values are selected (10, 24 and 50) mm/day (with different duration 10, 20, 30, 40, 50 and 60) day. Phreatic line level is the second parameter studied, at 2, 4, and 6m from surface. In addition to that, footing width is studied as the third parameter. Consequently, three different widths are selected (1, 2, and 3m). Slope angle is also selected as the fourth parameters; four different angles are selected (31, 45, 63 and 81) degree. As a result, a chart for routine design is obtained.
AVOIMET KIRJAT OSAKSI KORKEAKOULUJEN JULKAISUKULTTUURIA — HAASTEITA JA MAHDOLLISUUKSIA
Authors: Hirn Marja , Ylönen Irene
Published: November 2019

Kirjastojen on aktiivisesti oltava mukana edistämässä humanistis-yhteiskuntatieteellisen tutkimuksen moninaisuutta tukevaa avointa tieteellistä monografiajulkaisemista. Avoimet julkaisut ja aineistot eivät enää voi olla kirjastoissa niihin erikoistuneiden asiantuntijoiden tehtävää vaan ovat valtavirtaa, siksi niiden tuntemus kuuluu jokaisen kirjastoasiantuntijan osaamiseen.
OPPIMINEN JALKAUTUU KIRJASTOON — tilojen kehittäminen aiheena Helsingin yliopiston kirjaston Pedaforum-työpajassa
Authors: Suikka Minna
Published: November 2019

Pedaforum-päivät houkuttelivat 5.–6.6.2019 Helsingin yliopiston Kumpulan kampukselle yli 650 korkeakoulupedagogiikan asiantuntijaa ja edelläkävijää eri puolilta Suomea pohtimaanyliopisto-opetuksen nykytilaa ja tulevaisuutta.
TKI-AINEISTOJEN AVARUUS — 3AMKIN AINEISTONHALLINNAN KÄYTÄNNÖT JA OSAAMINEN
Authors: Merimaa Maija , Lahtinen Hanna
Published: November 2019

Tiedontuotannon vastuullisuuden lisääminen on tällä hetkellä yksi eurooppalaisen tutkimus- ja innovaatiopolitiikan keskeisiä pyrkimyksiä. Käytännössä tämä näkyy muun muassa siinä, että tutkimuksessa kerättävien aineistojen hallintaan kiinnitetään aiempaa enemmän huomiota. Monet rahoittajat edellyttävätkin hankehakemuksilta tutkimusaineiston tallentamista, jatkokäyttöä ja mahdollista jakamista pohtivaa aineistonhallintasuunnitelmaa. Ammattikorkeakouluissa aineistojen tallentamisen, jakamisen ja hyödyntämisen käytännöt ovat vasta kehittymässä.
Internalisasi Nilai Pendidikan Agama Hindu Dalam Membentuk Siswa Berkarakter Mulia
Authors: Murtini Putu , Wardhani Ni Ketut Srie Kusuma , Sugita I Wayan , Sudarsana I Ketut , Hendrawathy Putri I Dewa Ayu
Published: November 2019

The aim of national education is to educate the life of the nation and develop Indonesian people as a whole, namely people who believe in and fear God Almighty, virtuous character, have knowledge and skills, physical and spiritual health, a steady and independent personality, and social responsibility, and social responsibility and nationality. To improve morale and form students of noble character, SDN 2 Tamanbali implements the internalization of the value of Hindu religious education. The results of this study indicate that: (1) The factors that cause the internalization of Hindu religious education values in forming students with noble character in SD Negeri 2 Tamanbali are in the form of internal (student) and external factors (family, school, and community). (2) The process of internalizing the value of Hindu religious education in forming students of noble character in SD Negeri 2 Tamanbali through the process of learning, habituation, example, school culture development, and extracurricular activities. (3) Implications of internalizing the value of Hindu religious education to students of Tamanbali 2 Elementary School, namely the formation of religious student characters (sraddha and bhakti), discipline (yoga sadhana), courtesy and hospitality (samiksantam), honest (satya), and caring.

 
KOMPARASI AKURASI DUA MODEL KECURANGAN LAPORAN KEUANGAN MENGGUNAKAN BENEISH RATIO INDEX DAN ALTMAN Z SCORE PADA PERUSAHAN MANUFAKTUR Tbk 2016-2017
Authors: Islam Mohammad
Published: November 2019

Penelitian ini bertujuan untuk membuktikan secara empiris akurasi dua model kecurangan laporan keuangan antara beneish ratio index dengan altman z score pada perusahaan manufaktur di bursa efek indonesia 2016-2017. Penelitian ini bersifat kuantitatif dengan menggunakan data sekunder. Populasi dari penelitian ini adalah 162 perusahaan manufaktur yang terdaftar di bursa efek Indonesia yang memenuhi kriteria sampel yaitu sebanyak 82 perusahaan. Hasil dari penelitian ini, berdasarkan perhitungan menggunakan beneish ratio index terdapat 50 perusahaan tergolong manipulator. Sedangkan berdasarkan perhitungan menggunakan altman z score terdapat 28 perusahaan tergolong fraud/kebangkrutan Hasilnya dari tahun 2016 sampai dengan tanggal 26 Juni 2019 tidak ditemukan perusahaan manufaktur yang dikenai sanksi Otoritas Jasa Keuangan terkait kecurangan laporan keungan. Namun, bedasarkan berita online terkait dengan adanya indikasi kecurangan laporan keuangan ditemukan 3 perusahaan yaitu PT Tiga Pilar Sejahtera Food Tbk, PT Krakatau Steel (Persero) Tbk dan PT Bentoel Internasional Investama Tbk. Almant z score lebih mampu mendeteksi indikasi kecurangan atas ketiga perusahaan tersebut dibandingkan dengan beneish ratio index.
FAKTOR DETERMINAN INTENSI WHISTLEBLOWING
Authors: Sholihun Sholihun
Published: November 2019

Penelitian ini bertujuan untuk memberikan bukti empiris mengenai faktor determinan terhadap intensi whistleblowing. Subjek penelitian adalah auditor yang bekerja di Kantor Akuntan Publik di Jakarta dan sebanyak 98 responden. Penelitian ini menggunakan data primer untuk memperoleh informasi dari responden dengan menggunakan metode convenience sampling. Menggunakan teknik analisis regresi linier berganda diolah menggunakan perangkat lunak IBM SPSS versi 25. Adapun hasil penelitian ini secara parsial variabel komitmen organisasi, keseriusan pelanggaran dan saluran pelaporan anonim berpengaruh positif terhadap intensi whistleblowing, sedangkan variabel personal cost berpengaruh negatif terhadap intensi whistleblowing
STRATEGI KOMUNIKASI PEMASARAN MELALUI MEDIA WHATSAPP (STUDI KASUS GARUDA INDONESIA SOLO)
Authors: Priantoro Boedi
Published: November 2019

Abstrak

Penelitian ini dilatar belakangi karena banyaknya pengguna media sosial whatsapp sebagai media komunikasi untuk berbagi dokumen dan gambar,Video call,  bahkan untuk melakukan aktifitas marketing komunikasi. Dalam menghadapi persaingan di industri Penerbangan sangat diperlukanstrategi Komunikasi pemasaran untuk melakukan promosi, bentuk komunikasi pemasaran digital sangat tepat di era 4.0 saat ini. Strategi komunikasi pemasaran melalui media sosial ini dapat  menggunakan pendekatan DAMO (Discovery, Adventure, Momentum, dan Outlook). Penggunaan media sosial seperti whatsapp sekarang ini sudah digunakan para pebisnis, profesional, mahasiswa dan bahkan pelajar. Penelitian ini bertujuan untuk melihat strategi komunikasi pemasaran dengan memanfaatkan media whatsapp oleh sales dan Marketing Garuda Indonesia Solo dalam menyampaikan pesan-pesan promosi produk secara visual agar bisa tersampaikan kepada masyarakat. Penelitian ini menggunakan metodelogi kualitatif deskriptif. Data penelitian ini didapatkan dari informan-informan utama dari unit marketing dan sales garuda Indonesia Solo. Hasil dari penelitian ini adalah : pertama strategi komunikasi dengan menggunakan media whatsapp dapat memangkas biaya marketing, kedua, komunikasi dengan media whatsapp dengan sangat cepat sampai ke target market yang diinginkan, ketiga, dengan strategi komunikasi pemasaran melalui whatsapp, konsumen dapat memberikan feedback sehingga akan terjalin interaksi secara langsung.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI CORPORATE SOCIAL RESPONSIBILITY DENGAN PERTUMBUHAN PERUSAHAAN SEBAGAI VARIABEL MODERASI
Authors: Simamora Bachtiar Leo H , Herawaty Vinola
Published: November 2019

Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh variabel independen yaitu profitabilty, block holder ownership, leverage dan SIZE terhadap variabel dependen yaitu corporate social responsibility. Selain itu, penelitian ini menguji pertumbuhan perusahaan sebagai variable moderasi pada hubungan antara profitabilty, block holder ownership, leverage dan SIZE terhadap corporate social responsibility. Sampel dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada periode 2016 - 2018. Total sampel yang digunakan adalah 33 perusahaan yang diambil secara purposive sampling. Penelitian ini menggunakan analisis regresi logistik. Hasil uji hipotesis menunjukkan bahwa block holding ownership berpengaruh positif terhadap CSR, begitu pula dengan block holding ownership yang dimoderasi pertumbuhan perusahaan memiliki pengaruh positif terhadap CSR. Sedangkan profitabilitas, leverage, size tidak berpengaruh terhadap CSR. Demikian juga pertumbuhan perusahaan tidak dapat memoderasi hubungan profitabilitas, leverage, size terhadap CSR.
MOTION CAPTURE DALAM PENCIPTAAN GERAK NATURAL KARAKTER ALITA DALAM FILM “ALITA: BATTLE ANGEL”
Authors: Sijabat Alfo Jordan
Published: November 2019

Perkembangan film memiliki perjalanan cukup panjang hingga pada akhirnya menjadi seperti film di masa kini yang kaya dengan efek, dan sangat mudah didapatkan sebagai media hiburan salah satu contohnya film animasi. Film animasi, adalah film yang merupakan hasil dari pengolahan gambar tangan sehingga menjadi gambar yang bergerak. Animasi yang berasal dari Bahasa Yunani anima yang berarti memberi nyawa. Penelitian ini membahas pendekatan anatomi, visual edit dengan menggunakan karakter Alita dalam film Alita : Battle Angel. Alita adalah karakter animasi yang dibuat senatural dan sehidup mungkin. Ada beberapa faktor yang mempengaruhi efek natural dalam animasi yaitu gerak anatomis, motion capture, facial capture, serta elemen-elemen pendukung dalam proses editing. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan gerak anatomis tubuh yang didapat dari studi literatur.
STRUKTUR MODAL SEBAGAI VARIABEL INTERVENING LIKUIDITAS, PROFITABILITAS DAN STRUKTUR ASET TERHADAP NILAI PERUSAHAAN: TERBUKTIKAH SECARA EMPIRIS?
Authors: Asih Thorida Nur , Inayati Titik , Wany Eva
Published: November 2019

Tujuan dari penelitian ini adalah untuk menguji dan mendapatkan bukti empiris pengaruh likuiditas, profitabilitas, dan struktur aset terhadap nilai perusahaan dengan struktur modal sebagai variabel intervening pada perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia periode 2015-2018. Model analisis untuk penelitian ini menggunakan Structural Equation Modeling berbantuan SmartPLS versi 3.2.8. Penelitian ini menggunakan 156 laporan perusahaan property dan real estate bersumber dari www.idx.co.id. Hasil studi pada perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia untuk periode 2015-2018 menunjukkan bahwa likuiditas dan profitabilitas memiliki efek positif pada nilai perusahaan pada perusahaan property dan real estate yang terdaftar. Likuiditas berpengaruh negatif, profitabilitas tidak berpengaruh, dan struktur aset berpengaruh positif terhadap struktur modal. Struktur modal berpengaruh positif terhadap nilai perusahaan. Likuiditas berpengaruh negatif, profitabilitas tidak berpengaruh, dan struktur aset berpengaruh positif terhadap nilai perusahaan dengan struktur modal sebagai variabel intervening.
PELATIHAN PEMBUATAN BIBIT STEK BATANG TANAMAN REHABILITASI DI DESA KARANGSARI KABUPATEN KUNINGAN
Authors: Hendrayana Yayan , Ismail Agus Yadi
Published: November 2019

Ficus spp. is a plant that can play an important role in efforts to increase environmental conservation and forest productivity. One type is beunying (Ficus fistulosa) which is included in plant rehabilitation and restoration. Propagation of the Ficus plant is easiest to do by vegetative or stem cuttings. Therefore community service offers a solution in the form of making rehabilitation plant seeds through cuttings of Ficus fistulosa tree trunks. The hope is that by utilizing the rehabilitation tree that tastes in the Pasirbatang Block, this tourism mobilizing farmer group can produce rehabilitation plant seeds and increase the opinions of its members.Keywords: Vegetative propagation, training, empowerment.��AbstrakFicus spp. merupakan tanaman yang dapat berperan penting dalam upaya peningkatan konservasi lingkungan maupun produktivitas hutan. Salah satu jenis nya adalah beunying (Ficus fistulosa) merupakan yang termasuk ke dalam tanaman rehabilitasi dan restorasi. Perbanyakan tanaman Ficus yang paling mudah dilakukan adalah dengan cara vegetatif atau stek batang. Oleh karena itu pengabdian kepada masyarakat menawarkan solusi berupa cara pembuatan bibit tanaman rehabilitasi melalui stek batang pohon Ficus fistulosa. Harapannya adalah dengan memanfaatkan pohon rehabilitasi yang berasa di Blok Pasirbatang ini kelompok tani penggerak pariwisata ini dapat menghasilkan bibit tanaman rehabilitasi serta meningkatkan pendapatn para anggotanya.Kata kunci : Perbanyakan vegetatif, pelatihan, pemberdayaan
How to Make Sense of the Civil Prohibition of Hate Speech in Terms of the Promotion of Equality and Prevention of Unfair Discrimination Act 4 of 2000
Authors: Kok Johann Anton , Botha Louis
Published: November 2019

In this article the authors offer a workable interpretation of section 10 of the Promotion of Equality and Prevention of Unfair Discrimination Act 4 of 2000. Many constitutional law and freedom of expression scholars have argued that section 10 is at least in part unconstitutional. The authors of this article analyse these scholars’ views and chart a path towards saving section 10 from unconstitutionality. Section 10 is analysed by interrogating each of the requirements for hate speech as set out in the section: ‘no person’; ‘publish, propagate, advocate or communicate words’; ‘based on one or more of the prohibited grounds’; ‘that could reasonably be construed to demonstrate a clear intention’; ‘to be hurtful; be harmful or to incite harm; promote or propagate hatred’ and the defences listed in section 12. The article concludes with a proposal for legislative amendments to section 10 to remove any doubt about its constitutionality.
Land Matters and Rural Development: 2018
Authors: Pienaar Juanita M , Du Plessis Willemien , Johnson Ebrezia
Published: November 2019

Tthis note discusses the most important legal measures and court decisions pertaining to the three legs of land reform (restitution, redistribution and tenure reform), as well as unlawful occupation, housing, land-use planning, deeds and sectional titles.
Uwagi na temat ukształtowania domum vi introire na gruncie sullańskiej lex Cornelia de iniuriis
Authors: Nowicka Dobromiła
Published: November 2019

The article concerns the matter of domum vi introire – a violent intrusion into someone’s house, introduced into Roman Law by Cornelian law de iniuriis in 81 BC. The issue is analysed in the socio-political context of introduction of this regulation aimed to define its ratio legis as strictly connected to the goal of providing peace and safety in the city, and, by this means, establishing the new order. However, the conduct of domum vi introire was considered as closely related to the dignity of an individual from the very beginning, and as such complying with the concept of iniuria created within the praetorian edicts. It is exactly this feature that enabled the evolution of perception of this conduct in the direction of the contemporary concept of trespass.
Miasta w polityce władz Królestwa Polskiego w latach 1815–1830
Authors: Kania Rafał
Published: November 2019

Cities and towns are of greater significance than a mere form of urbanization. They are centres of development and progress, accumulating the potential of industry and culture. The 19th century was the period of a dynamic development of cities and towns in Europe. It also saw flourishing of the middle-class and maturing of their views and system of values. Those processes involved towns on the territory of the Commonwealth of Poland, although on a very limited scale. This was a consequence of the exceptional situation after the Third Partition in 1795. The article analyses the position of towns in the policy of the government of the Kingdom of Poland (1815–1830).
Miasta i mieszczanie w życiu politycznym przedrozbiorowej Polski
Authors: Wiązek Paweł
Published: November 2019

The publication is devoted to the problems of towns and townspeople’s activity in the political life of Poland before the Partitions. The research problem taken up in the article determined the possibly universal understanding of the term “town” and resignation from penetrating into terminological disputes related to the multifaceted nature of “urban issues” resulting in polemical multithreading in the doctrine. A broad temporal range was supposed to show the dynamics of undertaken actions, the progress and regress of the discussed process and the diversity of forms of active participation of towns and townspeople in the political life of the state. The author also tried to consider whether the explored issue could have an impact on the original direction of the systemic evolution of the former Polish statehood.
Sąd Diecezji Opolskiej i kanoniści opolscy po drugiej wojnie światowej
Authors: Sadowski Piotr
Published: November 2019

This article presents the Opole Diocesan Court in the years 1951–2018 and Opole canonists in the years 1945–2018. It discusses the functions, structure, history and profiles of judicial vicars of the court, and gives summary information focusing on Opole canonists. Members of the Opole Diocesan Court are compared with Opole canonists because the both groups have often created or co-created the both of these realities. The article does not present any statistical information or names of trials taking place before the Opole Diocesan Court during the analyzed period, or possible trial costs. Furthermore, it does not analyze court judgements or individual reasons for declaring the nullity of a marriage solemnized at the Roman Catholic church. While determining the composition of the court is relatively easy, the concept of canon law study of Opole is a more complicated matter. A person related to the Opole Diocese area by birth, upbringing, residence or job is recognized by the author as an Opole canonist. However, the above-listed factors are not always cumulative. In many cases, someone who is considered to be an Opole canonist may also be identified as belonging to other scientific circles. In the past few decades, the Opole canonist community has been composed of graduates of numerous Polish and foreign academic centers, and, afterwards, such people dealt with various research areas. Their publications, professional, social and organizational activities, and their membership of different associations are the evidence of proper creativity. Even if the author does not discuss detailed scientific achievements of Opole canonists, the above summary presentation shows that these achievements are rather extensive.
On the borderlines and the scope of pragmatics
Authors: Timofeeva Mariya K.
Published: November 2019

The paper elicits the questions concerning the borderlines of pragmatics, and analyzes some ways of resolving these questions. Contemporary pragmatics seems to be a distinct area of investigation, bringing together different, often conflicting theories and putting them under the same name; this makes it difficult to develop pragmatics on the whole, as an integral part of linguistics. Presumably, the cause of it lies in an unreasonably high degree of abstractness that is characteristic of the investigative area outlined by the founders of semiotics, primarily by Charles Pierce and Charles Morris. The paper suggests that pragmatics is one unified field, and the branches within it – as having stemmed from different strategies applied to specify the under-defined field. Each step of the way was began with conceiving some theoretical opacity, followed by posing the corresponding question, searching for an answer, and reaching the most appropriate solution. Since pragmatic phenomena are rather complicated, the process of further specification seems to be step-like. It presumably starts with primary questions about the borderlines, and then passes over to more specific notions and theories. This means that considering the borderlines of pragmatics is inseparable from considering its scope; one cannot speak about the former without taking into account the latter because every scientific borderline is inevitably drawn along some conceptual traces of previous research. Therefore, the question about the scope is also important, but only as far as it is substantial for discussing the borderlines. No doubt, the scope of pragmatics needs a more detailed analysis; so, it is necessary to study the links between different research areas in pragmatics.
Linguistic consciousness in the study of a language situation
Authors: Tsybenova Chechek S.
Published: November 2019

The article deals with the psycholinguistic aspect of the language situation. The main object of the article is the term «linguistic consciousness» considered as a linguocultural component of the language situation. The author analyses the specific features of linguistic consciousness of the modern bilingual Tuvans. Two levels of analysis are presented: structural and conceptual.
Quasi-conditional constructions in Catalan
Authors: Repnina Tatiana V.
Published: November 2019

This article aims to single out quasi-conditional constructions in Catalan and describe their main types. The author proceeds from the hypothesis that Catalan quasi-conditional constructions must show considerable similarity with quasi-conditional constructions in Russian, English, French, and other languages. The number of the constructions addressed is about 1 000 examples from Catalan texts by native Catalan authors and about 2 000 examples from Catalan texts by non-Catalan authors, selected by total sampling. The paper shows that quasi-conditional constructions, although formally similar to conditional constructions, differ on certain points from them. Their protasis does not express hypothetical condition, apodosis doesn’t imply consequence, the condition-consequence meaning is often missing from them altogether. In contrast to conditional constructions, transformation of quasi-conditionals ones into formally narrative constructions doesn’t change their meaning. Quasi-conditional constructions can be split into five major groups: presumptive constructions, constructions with protasis in the function of parenthesis, conditional-evaluative constructions, conditional-causal constructions, and logical conclusion constructions.
The observables selected as criteria for this classification include:
Construction meaning (comparative, existential, evaluative, causative constructions etc.);
Changeability of the main dependent clause order;
Use of markers. Both my analysis and literature on conditional constructions in other languages confirm that the structure of Catalan quasi-conditional constructions is similar to their counterparts in other languages. The findings can be used for teaching purposes as well as for research in Catalan, other Romance languages, or in typology/syntax.
New and traditional approaches to interpretation of the antithesis SENSE / SENSIBILITY in the title of J. Austin's novel
Authors: Bobyleva Tatiana V.
Published: November 2019

The purpose of analyzing possible interpretations of the antithesis Sense and Sensibility in the title of J. Austen's novel is to provide a theoretical basis for the author’s broader research. Presented also in other articles, the entire study is devoted to the analysis of different interpretations of the antithesis in French and Russian translations: both in the title and in the main message (macrocontext) of the novel. As a practical part of the research, the author presents in the current article her own arguments related to possible new interpretations of the antithesis. Namely: 1) hypothesis about a dual nature in the meaning of the antithesis itself: not only the traditional opposition "reason vs. feelings", but also the sense of objective reality vs. individual’s subjective sensibility; 2) comparison of the moral message of the novel (opposition "reason vs. feelings" in favor of the merits of reason) and modern theories of emotional intelligence. The author tries to prove that the four-branch model of emotional intelligence by P. Salovey and J. Mayer is based on the classic message – the merits of reason, however completed with commercial and pragmatic aspects. In addition, this new interpretation of the antithesis (sense of objective reality vs. individual’s subjective sensibility) is complemented by the author with her own possible Russian versions of the novel title, reflecting the new meaning and at the same time preserving the alliteration that the English original has.
Image of time in language consciousness of Russians and the Japanese
Authors: Palkin Alexei D.
Published: November 2019

Perception of the image of time in Russian and Japanese linguocultures is analysed. An association experiment has become the main experimental method. Three samplings are under consideration: that of Russians of the early 1990s, that of Russians of the early 21st century, and that of the Japanese of the early 21st century. Russians and the Japanese share general human values, but cultural differences stand out in association reactions of Russian and Japanese respondents. The experimental material available shows that the Japanese are more time-conscious than Russians. The Japanese tend to consider things in a long-term perspective, while for Russians a medium-term perspective is more urgent. The specificity of hieroglyphs leads the Japanese to perceiving a close connection between time and space, while the Russian language does not provide clues of the kind, which results in fewer reactions indicating space in Russian samplings. The paper argues that the perception of time image has altered in the Russian linguoculture recently. Russians of the early 1990s lost their axiological targets in the turmoil of the Soviet Union collapse, which is not characteristic of the 21st century Russians, who started to regain their emotional stability.
Axumin Positron Emission Tomography: Novel Agent for Prostate Cancer Biochemical Recurrence
Authors: Songmen Swachchhanda , Nepal Pankaj , Olsavsky Thomas , Sapire Joshua
Published: November 2019

Prostate cancer remains one of the top common cancers in terms of incidence and cancer-related deaths. Approximately 1/3rd cases develop biochemical recurrence during surveillance post-definite therapy. Multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) (including multiparametric prostate MRI), bone scan, and positron emission tomography (PET) using different tracers are being used for the characterization of the prostate cancer recurrence. CT and MRI do not provide physiological information, thus have lower sensitivity in detecting the metastasis. A bone scan has low sensitivity (depending on the prostate-specific antigen level) with low specificity as well. Among different PET tracers, Axumin PET appears to be the most promising tool. Axumin PET is Food and Drug Administration approved for the evaluation of prostate cancer biochemical recurrence. Several studies have shown that Axumin PET findings played a key role in treatment modification by finding otherwise undetected lesions. We briefly discuss the salient characteristics, imaging protocol and image interpretation criteria for Axumin PET in the workup of prostate cancer biochemical recurrence.
Demystifying and Unravelling the Factual Molecular Structure of the Biopolymer Sporopollenin
Authors: Mikhael Abanoub , Jurcic Kristina , Schneider Celine , carr David , Fisher Gregory L. , Fridgen Travis D. , Diego-Taboada Alberto , Mackenzie Grahame , BANOUB JOSEPH
Published: November 2019

Sporopollenin is a natural highly cross-linked biopolymer composed of carbon, hydrogen, and oxygen which forms the outer wall of pollen grains. Sporopollenin is resilient to chemical degradation. Because of this stability, its exact chemical structure and the biochemical pathways involved in its biosynthesis remains a mystery and unresolved. It is obvious that a well-conceived coherent study of the sporopollenin structure details will help immensely scientists in better understanding the chemistry of their current applications of sporopollenin exines such as drug delivery, peptide synthesis, micro-reactors, and wastewater purification. As well, it may also lead to the discovery of newer biomedical applications in the next coming years. We have identified and characterized the molecular structure of the clean, intact sporopollenin using mass spectrometric and nuclear magnetic resonance techniques. These analyses showed that sporopollenin is composed of a circular polyhydroxylated tetraketide polymer rigid backbone and a poly(hydroxyacid) branched network. The poly(hydroxyacid) network chains are attached by covalantly ether bonds to the polyhydroxylated tetraketides rigid backbone, forming the scaffold of the spherical sporopollenin.
Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins
Authors: Tranter Dale , Paatero Anja , Kawaguchi Shinsaku , Kazemi Soheila , Serrill Jeffrey D. , Kellosalo Juho , Vogel Walter K. , Richter Uwe , Thornburg Christopher C. , Oishi Shinya , McPhail Kerry L. , Ishmael Jane E. , Paavilainen Ville
Published: November 2019

Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target remain unknown. Here, we develop an optimized synthetic CbA photoaffinity probe (photo-CbA) and use it to demonstrate that CbA directly targets the Sec61α subunit of the trimeric Sec61 translocon. CbA binding to Sec61 results in broad substrate-nonselective inhibition of ER protein import and potent cytotoxicity against specific cancer cell lines. CbA targets a lumenal cavity of Sec61α that is partially shared with known Sec61 inhibitors, yet profiling against resistance conferring Sec61α mutations identified from human HCT116 cells suggests a distinct binding mode for CbA. Specifically, despite conferring strong resistance to all previously known Sec61 inhibitors, the Sec61α mutant R66I remains sensitive to CbA. A further unbiased screen for Sec61α resistance mutations identified the CbA-resistant mutation S71P, which confirms non-identical binding sites for CbA and apratoxin A and supports the susceptibility of the Sec61 plug region for channel inhibition. Remarkably, CbA, apratoxin A andipomoeassin F do not display comparable patterns of potency and selectivity in the NCI60 panel of human cancer cell lines.Our work connecting CbA activity with selective prevention of secretory and membrane protein biogenesis by inhibition of Sec61 opens up possibilities for developing new Sec61 inhibitors with improved drug-like properties that are based on the coibamide pharmacophore.
Convergent Synthesis of Trisubstituted Tetrahydrofurans via Bis-Thermally Reactive 1,5-Diene-Tert-Butyl Carbonates.
Authors: Grenning Alex , Emmetiere Fabien
Published: November 2019

Cascade reactions (also known as domino- or tandem reactions) are an efficient strategy for generating molecular complexity. We report that synergizing the thermal reactivity of 3,3-dicyano-1,5-dienes and tert-butyl carbonates result in stereospecific 2,3,4-trisubstituted tetrahydrofuran synthesis. While substituted tetrahydrofurans can be challenging to synthesize, this discovery converts readily available 1,5-dienes derived from aldehydes, malononitrile, and cis-buten-1,4-diol into complex tetrahydrofurans via a process involving thermal Cope rearrangement, Boc-deprotection, and oxy-Michael addition. Described herein includes background related to the discovery, optimization and scope, and representative functional group interconversion chemistry for the scaffolds.
Controlling Eu2+ Substitution towards a Narrow-Band Green-Emitting Borate Phosphor NaBaB9O15:Eu2+
Authors: Zhuo Ya , Zhong Jiyou , Brgoch Jakoah
Published: November 2019

Highly efficient, thermally stable, narrow-band phosphors that can be excited by a blue LED chip are crucial for energy-efficient light bulbs and display lighting. Here, a rare narrow-band, green-emitting phosphor based on the compound NaBaB9O15:Eu2+ is demonstrated. The emission peak is centered at 515 nm with a full-width at half-maximum (fwhm) of 61 nm (2294 cm−1), and a photoluminescence quantum yield of >80% using blue or near-UV LED excitation. This borate’s remarkable green emission stems from Eu2+ substituting on the smaller [NaO6] polyhedron instead of the larger and more favorable [BaO9] polyhedron. The phosphor also exhibits negligible thermal quenching up to 650 K owing to the wide band gap, high connectivity of the rigid NaBaB9O15 crystal structure, and the depopulation of trap-states. This combination of optical properties and its straightforward synthesis conditions makes NaBaB9O15:Eu2+ an ideal green phosphor for next-generation LED-based lighting or display systems.
Analysis of Benzenoid Substitution Patterns in Small Molecule Active Pharmaceutical Ingredients
Authors: Nilova Aleksandra , Stuart David
Published: November 2019

An analysis of benzenoid substitution patterns in small molecule active pharmaceutical ingredients (APIs) approved by the FDA reveals a preference for 1,4-substituted (para), 1-substituted (mono), 1,2,4-substituted, and 1,2-substituted (ortho) arenes. Notably, these substitution patterns are widely commercially available and readily accessible by electrophilic aromatic substitution (SEAr), but more highly substituted and contra-electronic substitution patterns are severely underrepresented in drug substances. Finally, structural variation decreases with increasing substitution and there is a strong reliance on natural product scaffolds in drugs with more highly substituted benzenoid rings.
Antibacterial activity of water spinach herbs against acne-inducing bacteria
Authors: Singgih M  , Ivan A  , Fidrianny I
Published: November 2019

Acnes is commonly caused by infection by Propionibacterium acnes when the sebum is overproduced from the body. Based on previous research, water spinach extract had antimicrobial activity. The purpose of this study was to determine the antibacterial activity of water spinach (Ipomoea aquatic Forsk.) herbs extract against bacteria Propionibacterium acnes. Extraction was carried out by the reflux method using three different polarity solvents. The extracts were evaporated using a rotary evaporator. Antibacterial activities were assessed by using disc diffusion, microdilution, and equality to reference antibiotics. All three extracts of water spinach herbs had better antibacterial activity against Gram-positive bacteria than Gram-negative bacteria. The ethanol-water spinach herbs extract had the best antibacterial activity against P. acnes. The minimum inhibitory concentration (MIC) value of ethanol-water spinach herbs extract on P. acnes was 1280 µg/ml while the minimum bactericidal concentration (MBC) value was > 5120 µg/ml. The equivalency of ethanol-water spinach herbs extract to tetracycline hydrochloride presented 1163.87 µg ethanol extract (with density 1% extract: 0.780) equal to 1 µg tetracycline hydrochloride. All three extracts of water spinach herbs had antibacterial activity against P. acnes. The ethanol extract had the best antibacterial activity against P. acnes among all three extracts.
RE-ACTUALIZATION OF HERRITAGE OF SURABAYA IN SOCIAL STUDIES LEARNING
Authors: Hermawan Eko Satriya
Published: November 2019

Development of IPS learning media is still limited to the use of maps and power points, developed by teachers and students themselves. Teachers realize that in learning social studies (IPS) is needed the use of media learning, but because of the limitations of media owned schools so they rarely use the media as a supporter of the learning process. In addition to factors of facilities and infrastructure is also limited ability of teachers in making media and cost factors and time. This research used reseach and development (R & D) approach, which was conducted in Surabaya. The result obtained showed the characteristics of IPS education as a synthetic discipline. IPS education not only synthesizes the concept of relevant concepts between educational sciences and the social sciences but also the purpose of education and development as well as social problems in social life will be a consideration of educational materials IPS. That the identity and context of children's social and culture plays an important role in the development of social studies.
Effects of TASC Learning Model (Thinking Actively In A Social Context) on Ability Problem-solving in Natural Resource Management Materials
Authors: Mutaqy Rosikh Musabikha , Nasution Nasution , Purnomo Nugroho Hari
Published: November 2019

This study aims to analyze the effect of the TASC learning model on students' ability to solve problems in natural resource management material. This study uses an experimental method with the design of Non-equivalent Pretest-Postest Control Group Design. The results of this study indicate that the TASC learning model has an effect on students' problem solving abilities in natural resource management materials, where experimental class students who use the TASC learning model have better problem solving skills than the control class that uses the class discussion model. in natural resource management material. Based on the results of hypothesis testing, it was concluded that there were significant differences between students learning using the TASC learning model (Active Thinking in Social Context) with students learning to use cooperative type class discussion learning models to solve problems.
The Effect of STAD Learning Model On The Motivation And Social Studies Knowledge In Junior High School
Authors: Alim Muhamad Miftahul , Prasetyo Ketut , Sunarto Sunarto
Published: November 2019

This study aims to determine the consistent changes of students' learning motivation resulting from the learning process using the STAD learning model and its effect on student learning outcomes. This study was the pretest-posttest control group design. Sample in this study was VIII class who were randomly determined. The data obtained then tested different using independent sample t-test. The results showed that the two research classes experienced a positive change in the motivation and learning outcomes of students. In the experimental class with STAD learning model showed motivation and learning outcomes that were better than class control. The post-test calculation shows that learners' motivation with the Sig. (2-tailed) 0.003, where 0.003 <0.05 means that there are significant differences. Learning outcomes that show the value of Sig. (2-tailed) 0,000, where 0,000 <0,05 means that there are significant differences between the experimental and control classes. The existence of significant differences indicates that there is an effect of the STAD learning model on students' motivation and learning outcomes.
Improve Creative Thinking Ability With Posing Problem Learning
Authors: Yanto Supri , Nasution Nasution , Wisnu Wisnu
Published: November 2019

The purpose of this study is to describe the students' creative thinking skills in social studies learning using the Problem Posing model. The subjects in this study were 28 eighth grade students of SMP Negeri 1 Tulangan academic year 2019. Researchers used primary data and data collection techniques, namely tests. Tests were carried out before and after learning. The results showed that the test results of independent sample t-test posttest creative thinking abilities of learners shows that there are differences in the ability of creative thinking between the experimental class and class control after being given treatment. Based on the analysis of the t-test, it was concluded that the problem posing learning model influenced students' creative thinking abilities. This research is useful for teachers, that is, they can develop teacher insights to be more innovative and creative in creating fun learning activities in the classroom and increasing students' knowledge competencies and creative thinking abilities. The problem posing learning model is implemented into the class because it can improve the ability of creative thinking and understanding in addressing problems and conflicts that occur in society and is expected to optimize the ability to think creatively.
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Authors: Abdi Jurnal
Published: November 2019

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IMPLEMENTASI IPTEK BAGI MASYARAKAT (IbM) PADA PENGRAJIN MINIATUR MENARA
Authors: Fiati Rina , Wijayanti Esti
Published: November 2019

This activity of Community Service aims to develop and form an economically independent group of society,to enhance the development of minaret miniature's craftsmen in seizing market opportunities by means ofimproving its product quality and marketing. The specific target expected to reach by the partner-craftsmenis to improve the craft design so as to develop its sales. The method used as a solution to overcome theseproblems is the accompaniment and strengthening of the production process. The problem solving is in itsproduction process, i.e. to produce quality products and e-commerce training for minarets miniature'scraftsmen in Bacin Village, Kudus Regency. The results obtained from the activity are Introduction ofcomputer information technology to craftsmen-partners, Introduction and training of internet and websitemanagement, making e commerce for minaret miniature's craftsmen to market their products on ecommerce basis.
PENGGUNAAN MEDIA SOSIAL (YOUTUBE) SEBAGAI MEDIA INOVATIF DALAM PEMBELAJARAN DI MADRASAH GRESIK
Authors: Abdulloh Abdulloh , Fahmi Mochamad Zakki , Siswanto Imam
Published: November 2019

The community service activities have been carried out at Madrasah Aliyah Masyhudiyah Gresik. Thepurpose of service is: 1) providing understanding to teachers in making learning material throughYouTube, 2) providing motivation to teachers, 3) building teachers' confidence, and 4) using YouTube forfun learning tools. Methods of activities are lectures, demonstrations, workshops and training using theCamtasia application. Data collection techniques are based on the results of the pretest - posttest andparticipatory approach. Data analysis to measure the success category is done by calculating thepercentage of correct answers for each aspect asked, the percentage of learning videos made and thenumber of learning videos uploaded. The results of the activities are: 1) the teacher's understanding inmaking construction of video-based learning materials on average increased by 52%, 2) 100% of teachershave made videos for learning media using the Camtasia application, 3) 30% of teachers have uploadedlearning videos on social media YouTube This activity resulted in an increase in teacher understandingrelated to the importance of using YouTube as a learning medium and videos containing learning materialscreated by madrasa teachers.
Reduction of multidimensional poverty and strength of social inclusion through a municipal program. The case of the impact assessment of the program «Un Solo San Pedro»
Authors: Portales Luis
Published: November 2019

Poverty is the Objective of Sustainable Development number 1, encouraging local governments to create programs aimed at its reduction. However, poverty worldwide and in Mexico has been reduced marginally, making impact assessments more critical. In this article, it is presented the results of the evaluation of the «Un Solo San Pedro» program, aimed at reducing multidimensional poverty and strengthening social inclusion in fourteen neighborhoods of San Pedro Garza García, a Mexican municipality. The results show the impact that the program had in the reduction of multidimensional poverty and the improvement in social inclusion indicators, as well as the difficulty that represents the change of cultural patterns linked to this problem. The article contributes to the generation of knowledge about the value of these evaluations in the understanding of poverty and the impact that programs have on their eradication.
Aspectos generales del conocimiento simbólico y diagramático: el caso de los diagramas de Venn
Authors: Canela Morales Luis Alberto , Ruiz Sosa Francisco Gabriel
Published: November 2019

El objetivo de este ensayo es exponer, por un lado, la naturaleza simbólica del razonamiento lógico formal y, por otro lado, su naturaleza diagramática. En particular, este ensayo trata de exponer qué significa conocer por medio de diagramas y símbolos y cómo este conocimiento está vinculado al carácter formal de la lógica. Como caso concreto de estudio se analizará el aspecto diagramático y didáctico de los diagramas de Venn y su enseñanza en el Nivel Medio Superior y Superior.
Puente de los asnos: una propuesta de aplicación para la enseñanza
Authors: Gómez Álvarez José Enrique
Published: November 2019

Se presenta una nueva versión simplificada del “Puente de los Asnos” (Pons asinorum) desarrollado a partir de la interpretación de fuentes clásicas y del reajuste del mismo propuesto por Hamblin (1976). Se describe el sentido y alcance del Pons asinorum así como otros intentos históricos de la automatización del silogismo. Posteriormente se compara a Juan de Santo Tomás y Aristóteles para explicar los criterios para la elaboración de la aplicación informática señalando las mejoras técnicas y conceptuales dando lugar al software del Puente de los Asnos. Se mues- tra cómo el software y la enseñanza por medio del mismo puede ser un detonador de nuevos modos de razonar a los estudiantes potenciales, en consecuencia, se demuestran nuevas formas de enseñanza a través de la lógica tradicional.