bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of the relationship between radiographic parameters and patient-reported outcomes in Lenke type-1 adolescent idiopathic scoliosis
Authors: ARIK İlker , BÜKER Nihal , ŞAVKIN Raziye , ÖK Nusret , KITER Ahmet Esat
Published: March 2023

Purpose: This study aims to examine sagittal alignment and spinopelvic parameters in patients with surgically treated Lenke type-1 AIS and to determine the relationship between radiographic outcomes and body image, self-esteem, disability and anxiety.

Materials and methods: Twenty-five patients who underwent posterior spinal fusion surgery and followed up for more than 1 years were eveluated (mean age 14.20±1.63 years) retrospectively. Radiographic analysis of A/P and lateral full spine standing radiographs was carried out with the Surgimap software. The patient-reported outcomes were evaluated with Walter Reed Visual Assessment Scale, Rosenberg Self-Esteem Scale, Oswestry Disability Index and Beck Anxiety Inventory. Correlations between deformity measures and patient-reported outcomes were evaluated by the Pearson’s correlation test.

Results: There was a significant decrease in Cobb angle, AVT, trunk shift, T1 tilt and pelvic incidence at early postoperative and final follow up compared with the preoperative measurement (p0.05).

Conclusion: Patient-reported outcomes are important in terms of evaluating the physical and psychosocial effects of scoliosis-related deformity from the patient's perspective. However, low or no correlation was found between radiographic evaluation and patient-reported outcomes. This result indicates that objective and patient-reported results should be interpreted separately.
Research on digital native media: an emerging topic in the field of digital communication
Authors: Vázquez-Herrero Jorge , Negreira-Rey María-Cruz , López-García Xosé
Published: March 2023

Digital native media have gone through different stages since their emergence in the last decade of the twentieth century under the shadow of the evolution of the ‘network of networks’ and digital transformation. Despite the influence that legacy media have exerted on the models of many digital media, the efforts they have made to find their own way in the digital communication ecosystem have resulted in the introduction of new practices and strategies that have fuelled renewed debates on journalistic frontiers. The aim of this paper is to review the birth, evolution and current landscape of digital native media with special attention given to research in this field. This is an object of study with its own and differential characteristics in relation to legacy media, which attracts the focus of more and more digital communication researchers every day. To offer a current assessment of such research, a systematized review of articles published in scientific journals included in the Web of Science and Scopus databases was carried out. The results show that the conceptualization of digital native media, their mapping in media ecosystems and comparison with legacy media, the study of their typology and characteristics, research on their economic and organizational models, the analysis of their content, and their relationship with audiences are among the main objects of research. These media constitute a fundamental sector in the current media ecosystem, which will require multidisciplinary and interdisciplinary perspectives in their research to face the challenges of digital media, digital native media and digital journalism.
Recent photographic records, a new specimen, and a review of the distribution and habitat associations of Caluromys lanatus (Mammalia, Didelphidae) in Paraguay
Authors: Owen Robert D. , Weiler Gustafson Andrea , Smith Paul
Published: March 2023

La cuica lanosa, Caluromys lanatus, se distribuye ampliamente en Sudamérica al este de los Andes, incluyendo el este y sur de Paraguay. Sin embargo, su hábitat y distribución en Paraguay están poco documentados. Recopilamos los registros reportados en la literatura científica, especímenes y fotografías de procedencia conocida, para proporcionar una evaluación actualizada de esta zarigüeya en Paraguay. Enumeramos y mapeamos 15 localidades (una de las cuales es probablemente errónea) y proporcionamos comentarios sobre cada uno de los registros. En Paraguay, la especie está asociada principalmente al Bosque Atlántico, pero también puede encontrarse en otros hábitats boscosos.
Zakaz dyskryminacji genetycznej w prawie międzynarodowym publicznym
Authors: Kofin-Brończyk Klaudia
Published: March 2023

Dyskryminacja genetyczna oznacza traktowanie kogoś w odmienny sposób ze względu na jego cechy genetyczne, które pozwalają stwierdzić, jakie predyspozycje zdrowotne ma człowiek. Przykładem jest gene­tyczne uwarunkowanie do zapadnięcia na chorobę Huntingtona czy ryzyko rozwoju raka jelita grubego. Z punktu widzenia prawa pojawia się ważny problem: czy wiedza o danych genetycznych może być wykorzystana w sposób, który będzie dyskryminował jednostkę? Przykładowo problem ten może polegać na tym, że ubezpieczyciel odmó­wi zawarcia z nami umowy dotyczącej ubezpieczenia na życie lub podwyższy naszą składkę.
Pierwszą metodą badawczą jest analiza dogmatyczna, która obejmuje dwa elementy: metodę ilościową i jakościową przeprowadzenia inwentaryzacji prawa międzynarodowego oraz metodę prawnodogmatyczną, tj. krytyczną analizę literatury i orzecznictwa. Drugą metodą badawczą jest analiza prawnoporównawcza, która ma na celu porównanie regulacji występujących w uniwersalnym oraz regionalnym systemie praw człowieka.
Celem niniejszego artykułu jest zbadanie, na ile kwestia zakazu dyskryminacji genetycznej jest uregulowa-na w prawie międzynarodowym publicznym. Dlaczego dyskryminacja genetyczna powinna być wyróżniona na tle ogólnych norm dyskryminacyjnych? Wiele aktów prawnych (np. Powszechna Deklaracja Praw Człowieka) zawiera ogólne normy antydyskryminacyjne. Przykłady dyskryminacji genetycznej wskazują jednak, że obecnie istniejące regulacje mogą okazać się niewystarczające. Artykuł jest także próbą odpowiedzi na pytanie, czym jest dyskryminacja genetyczna.
Ks. Wojciech Góralski, „Iudicis est ius dicere … Wykluczenie nierozerwalności małżeństwa (kan. 1101 § 2 KPK) w najnowszym orzecznictwie Roty Rzymskiej (2018-2021)”
Authors: Sztychmiler Ryszard
Published: March 2023

Recenzja książki: Ks. Wojciech Góralski, "Iudicis est ius dicere… Wykluczenie nierozerwalności małżeństwa (kan. 1101 § 2 KPK) w najnowszym orzecznictwie Roty Rzymskiej (2018–2021)", Wydawnictwo Bernardinum, Pelplin 2022, ss. 248.
Професор Бережницький М.М. — вчитель і педагог
Authors: Katerenchuk I.P.
Published: March 2023

У статті наведено спогади про діяльність одного із фундаторів Прикарпатської школи внутрішньої медицини галицького професора-інтерніста Мирослава Миколайовича Бережницького.
Etnomathematics In E-Modules Using A Scientific Learning Approach For JHS Students
Authors: Faisyal Intan Dyra Shari , Supriadi Nanang , Pratiwi Dona Dinda
Published: March 2023

This study has the aim of obtaining a suitable e-mathematical module, valid and interesting, and effective for use in learning. The research method used is development research or R&D (Research and Development) through the ADDIE approach (Analysis, Design, Development, Implementation, and Evaluation) with the subject of State Junior High School (Junior High School) students in Bandar Lampung City. The instruments used are interviews, questionnaires (questionnaires) in the form of expert validation questionnaires, needs analysis, and product trials to students, as well as documentation. The results of the study based on the validation of material and media experts obtained scores of 3.55 and 3.43 with the criteria "fit for use". The results of the product attractiveness trial to students for large groups and small groups obtained scores of 3.71 and 3.73 on the "very interesting" criteria. The effectiveness test of the N-gain score obtained a result of 0.71 which was classified in the "high" category.
Binary Logistics Regression To Predict The Opportunity Of SNMPTN Graduation In Statistics Study Program Of Tanjungpura University
Authors: Satyahadewi Neva , Tamtama Ray , Perdana Hendra , Huriyah Syifa Khansa
Published: March 2023

The National Selection of State University Entrance or Seleksi Nasional Masuk Perguruan Tinggi Negeri (SNMPTN) is one of the selections for high school students seeking higher education. The Statistics Study Program as one of the study programs at Tanjungpura University has a capacity of 20 seats in the SNMPTN. This limited capacity causes prospective students to prepare the right strategy in order to be accepted through the SNMPTN. In this study, logistics regression was used to predict the probability of graduation status on the SNMPTN path in the Statistics Study Program of Untan. Binary logistic regression is a statistical analysis technique for representing the relationship between a response variable with two (binary) categories and one or more predictor variables on a continuous or categorical scale. Data for this study were primary data from a questionnaire that received 93 samples. The response variable used is graduation status (Y) through the SNMPTN in Statistics Study Program, Tanjungpura University classified as 1 (passed) and 0 (not passed). Based on the results of the study, it is known that the variables that have a significant effect on graduation status are the status of choice in Statistics Study Program (X1), national level achievement ownership (X3), the average value of Mathematics (X4), the average value of Chemistry (X6), Biology average score (X7), Indonesian average score (X8), and English average score (X9). Meanwhile, provincial level achievement (X2) and Physics average (X5) did not have a significant effect on graduation status. The binary logistic regression model obtained has an accuracy error of 15,05% with an accuracy rate of 84,95%, meaning that this model has a good criteria.
Utilization Of Website-Based Learning Videos For Mathematics Learning
Authors: Pratama Singgih , Hendriana Benny
Published: March 2023

This research has the aim of developing learning media in website-based mathematics lessons by using video as a material deliverer. Research and Development with a 4D model is used in this study in the process of developing mathematics learning media using the website. The interpretation, design, development, and distribution are the four main stages in the 4D model. There are 77 grade VII students of SMPN 11 Depok as the subjects of this research. Media expert validation is the source of the validity test in this study while the validity of media experts and student responses are the basis of the practicality test in this study so that the development of website-based media in this study is assessed as valid
Development Of Website-Based Learning Media Combined With Geogebra On Pythagoras Materials For VIII-Class Students Of Smp Negeri 1 Pasawahan, Kuningan District
Authors: Zahra Nisrina Az , Cahdriyana Rima Aksen
Published: March 2023

This study aims to develop a website-based learning media on Pythagorean material. This study uses a development research method with the Research and Development (R&D) method with a 4D model (Define, Design, Development, and Dissemination. The research was carried out at SMP Negeri 1 Pasawahan Kuningan Regency  by dividing into two trials, namely 5 students for small class trials and 26 students for a large class trial. Instruments of the assessment used a questionnaire assessment of material experts, media experts and student responses. The results in this study were from material experts with an average of 3.71 categorized as very valid, from media experts with an average of 3.63 categorized as very valid and student responses in the interesting category with an average percentage of 77.23% so that the website-based learning media with Pythagorean material that the researcher developed is feasible to use in the learning process.
The Effectiveness of Using Android-Based Interactive Learning Media Development Results With The Assistance of Smart Apps Creator (SAC) on Social Aritmatic Materials
Authors: Romdhoni Mohammad Rifqi , Agustina Eka Nurmala Sari , Ayuningtyas Nurina
Published: March 2023

This study aims to: determine the effectiveness of the use of instructional media, and determine the practical effect of using instructional media on student learning outcomes. The research method used is descriptive quantitative which aims to describe the practicality of using learning media, the effectiveness of using learning media, and the effect of using learning media on student learning outcomes. The analysis technique used in this study to determine the effect of the practicality of using instructional media on student learning outcomes is simple linear regression analysis. The results showed that the practicality level of learning media was 80%, and the completeness level of students was 76%, so it can be concluded that the learning media developed met practical and effective criteria. The results showed that the assumptions of linear regression were met, namely the data were normally distributed, the data were homogeneous and there was no correlation between the data. So that a simple linear regression test can be carried out partially and the results obtained are tcount = 5.617 which is greater than the value ttable = 2.04841 which means H0 is rejected, so the practicality of using instructional media influences student learning outcomes.
Ethnomathematics Exploration At The State Museum Of North Sumatra
Authors: Sagala Siti Aisyah , Hasanah Rusi Ulfa
Published: March 2023

Ethnomatematics can be used as a way to convey local culture and mathematics simultaneously, because ethnomatematics is a combination of culture and mathematics. The State Museum of North Sumatra is one of the historic buildings of North Sumatra which contains ethnomathematics concepts. This study aims to explore the ethnomathematics contained in the State Museum of North Sumatra. This research is a qualitative descriptive study with an ethnographic approach. The research subject was one of the officers of the State Museum of North Sumatra. Data collection techniques include observation, interviews, documentation and literature studies. The results of the study prove that there are geometric shapes and geometric shapes in the North Sumatra State Museum building and several historical heritage objects in the North Sumatra State Museum. And there is the concept of geometric transformation in the ornaments of the North Sumatra State Museum.
Sistem informasi pendaftaran online pada lembaga bahasa universitas muhammadiyah palembang berbasis web
Authors: Fauzan R.M. Rizki , Mukmin Chairul
Published: March 2023

Penelitian ini dilatarbelakangi dari beberapa masalah yang muncul di Lembaga Bahasa (LB) Universitas Muhammadiyah Palembang (UM Palembang) yang diketahui oleh peneliti yang juga merupakan salah satu staf di LB UM Palembang. Kesulitan mahasiswa dalam memahami proses pendaftaran kegiatan mereka di LB serta kekurangan sistem pendataan dan pelaporan manual yang sebelumnya di gunakan oleh LB UM Palembang mendasari dua permasalahan yang diangkat dalam penelitian ini. Permasalahan penelitian ini adalah bagaimana cara mengembangkan sistem pendaftaran online yang baik dan bagaimana hasil pengamatan ahli terhadap sistem pendaftaran yang telah di buat. Metode pengembangan aplikasi yang digunakan dalam penelitian ini adalah metode Prototype dan metode pengumpulan datanya adalah berupa kuisioner yang di berikan kepada ahli materi dan ahli media. Hasil penelitian menunjukkan bahwa sistem informasi pendaftaran berbasis web dapat membantu proses pendaftaran. Menurut evaluasi ahli, perangkat lunak ini sangat layak dalam hal akurasi dan keandalan, serta dalam hal kelengkapan dan kemudahan penggunaan.
Sistem Pakar Mendeteksi Tindak Pidana Cyber Crime untuk Penanganan Komputer Forensik Menggunakan Backward Chaining
Authors: Bellini Yustida , Sutabri Tata
Published: March 2023

Sistem pakar mendeteksi tindak pidana cybercrime untuk penanganan komputer forensik menggunakan backward chaining adalah suatu sistem yang dirancang untuk mendeteksi tindak pidana cybercrime yang dilakukan oleh pelaku kejahatan. Masalah yang dihadapi adalah bagaimana mendeteksi tindak pidana cybercrime yang dilakukan, pasal yang sesuai dengan kejahatan cybercrime yang dilakukan dan hukuman apa yang sepantasnya diberikan kepada pelaku kejahatan cybercrime. Tujuan dibuatnya sistem pakar ini yaitu untuk memudahkan dalam proses mendeteksi tindak pidana cybercrime yang dilakukan, pasal yang sesuai dengan kejahatan yang dilakukan, dan hukuman yang sepantasnya didapatkan oleh pelaku kejahatan, agar pelaku kejahatan tidak akan mengulangi lagi kejahatan yang pernah dilakukan. Metode penelitian dalam pembuatan sistem pakar ini yaitu menggunakan metode observasi, studi pustaka dan wawancara. Sistem pakar berkembang melalui pembuatan sistem yang menggunakan bentuk pemograman Hypertext Prepocessor (PHP) dan juga basis data menggunakan MySQL. Pad pembuatan desain menggunakan HTML dan CSS yang mana pada pembuatan sistem ini dapat memiliki hasil yaitu agar dapat membantu dalam proses pendeteksian tindak pidana cybercrime untuk penanganan kompoter forensik sehingga dapat diketahui dengan mudah kejahatan-kejahatan yang terjadi, jenis kejahatan dan hokum kejahatan cybercrime yang dilakukan.
Zsarnokölés és királyi felelősség a francia vallásháborúk idején
Authors: Kevevári István
Published: March 2023

Jelen tanulmányban a reformáció 16. századi politikai teológiáját vizsgálom az ellenállás és a zsarnokölés problémáját középpontba helyezve. Célom annak a szellemi mozgásnak a leírása a rendelkezésre álló elsődleges források elemzésének segítségével, hogy a világi hatalommal való szembenállás alátámasztását miként kívánták a reformáció legfontosabb szerzői megindokolni.Álláspontom szerint a francia vallásháborúk idején a királyi hatalom alapjait tekintve lényeges változás állt be, amely túlmutatott a vallási megfontolásokon. Kálvin János és főleg az őt követő francia protestáns monarchomachok azonban már egy jogi alapokon álló ellenállási jogról beszéltek, sőt a királyi hatalom népi eredetének tanával a modern politikai filozófiát is megelőlegezték.
Life Style Factors and Morbidity Pattern of Biscuit Company Workers in Puducherry City, India
Authors:   Department of Community Medicine, ADepartment of Community Medicine, Aarupadai Veedu Medical College, Puducherry, India.arupadai Veedu Medical College, Puducherry, India., Fathima Aumrin , Daniel Arun ,   Department of Community Medicine, Aarupadai Veedu Medical College, Puducherry, India.
Published: March 2023

Background: The baking industry does not have a hazardous occupational environment; however, it is not free from ergonomic derangement. The biscuit factory workers are exposed to noise, heat, odor, flour dust, sugar dust, and biscuit dust Methods: A cross-sectional study was conducted on all males and females of more than 18 years of age among employees of a biscuit company in Puducherry City, India, who met the inclusion criteria. According to previous research, the sample size was calculated at 494. We used the simple random sampling method. The data regarding participants’ sociodemographic variables, namely dietary patterns, physical activity, and addictions (including alcohol and smoking) were recorded using a pretested semi-structured questionnaire. The statistical analysis was done in the SPSS software, version 28. Results: Most of the participants (41.8%) were in the productive age group (18 to 30 years). The prevalence of hypertension and diabetes mellitus was 62.69% and 37.31%, respectively. Skin disorders (14.2%) were shown to be the most common cause of morbidities, followed by dental morbidity at 13.4%. Meanwhile, the least of the participants were in musculoskeletal morbidity (10%). There was an association between mixed diet, physical inactivity, alcoholic and tobacco consumption, and fruit consumption of fewer than 2 days per week with noncommunicable diseases. These differences were statistically significant (P≤0.05). Conclusion: The employees of the biscuit factory are exposed to chemicals that may be linked to morbidities. The non-communicable diseases were also more prevalent among tobacco and alcohol users, suggesting more research to determine whether these behaviors were stress busters for tension and discomfort. Nearly all of the employees in the companies had undergone a sort of medical examination in recent years. This shows that the workplace has high safety and sanitary requirements.
Investigating the Effectiveness of Art Therapy Based on Painting on Sleep Quality of Pregnant Women
Authors:   Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University, Kerman, Iran., Sharifpour Latifeh , Askarizadeh Ghasem ,   Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University, Kerman, Iran., Bagheri Masoud ,   Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University, Kerman, Iran.
Published: March 2023

Background: Various factors, such as pregnancy, can lead to irregular sleep patterns. Sleep disturbances are common during pregnancy, leading to adverse maternal and neonatal outcomes. Accordingly, this study aims to examine the effectiveness of art therapy based on painting on the sleep quality of pregnant women in the third trimester. Methods: This was a quasi-experimental study followed by a pre-test, post-test design and a control group. The statistical population included pregnant women in their third trimester of pregnancy who were referred to 22 Bahman Health Center of Kerman City, Iran, in 2019. According to the inclusion criteria, 34 individuals were selected via the convenience sampling method and randomly assigned into the experimental (n=17) and the control group (n=17). To collect the data, we used the Pittsburgh sleep quality index. Then, twelve 90-min sessions of art therapy based on painting were carried out on the experimental group. After completing these sessions, we conducted a post-test. Data analysis was performed by multivariate analysis of covariance and the Bonferroni post hoc test in the SPSS software, version 26. Results: Art therapy based on the painting had significant effects on sleep quality and its components (P<0.001), while no significant differences were found in the control group (P>0.05). Conclusion: Art therapy based on painting can effectively improve pregnant women’s sleep quality. Accordingly, applying this method is recommended to improve the status of these individuals.
Investigating the Effects of Cognitive-Behavioral-Therapy-based Psychoeducation Program on University Students’ Automatic Thoughts, Perceived Stress, and Self-efficacy Levels
Authors:   Department of Nursing, School of Health Sciences, Harran University, Şanlıurfa, Turkey., Kaplan Veysel , Emin Düken Mehmet ,   Department of Nursing, School of Health Sciences, Harran University, Şanlıurfa, Turkey., Kaya Rabia ,   Department of Nursing, School of Health Sciences, Harran University, Şanlıurfa, Turkey., Almazan Joseph ,   Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Published: March 2023

Background: University life is a special period in which students take full responsibility for their lives, especially as individuals. This period includes many positive and negative situations. As a result, they need serious psychological support to cope with the potential or real problems they experience. This study aims to determine the effects of cognitive-behavioral-therapy-based psychoeducation programs on university students’ automatic thoughts, perceived stress, and self-efficacy levels. Methods: This was a quasi-experimental study with a single group pre-test and post-test design. The research was carried out at a university in Turkey from October 1 to November 15, 2022. The sample consisted of 223 students who agreed to participate in the research. The psychoeducation program prepared within the scope of the study was conducted face-to-face for four 45-min sessions. In this study, we used an individual introduction form, automatic thought questionnaire, perceived stress scale, and general self-efficacy scale. Data analysis was done via SPSS software, version 23. To analyze the data, we used descriptive statistics along with the Pearson correlation test and the Spearman correlation test. Results: A total of 73.4% of the students who participated in the research were female and 49.5% stayed in the student dormitory. The economic situation of 53.2% was moderate and 41.4% to 67.1% of the students had a good relationship with their families, while 63.5% had a good relationship with their friends. After the psychoeducation, a significant decrease was observed in the mean scores of students’ automatic thoughts and perceived stress, while their self-perception scores increased significantly (P<0.05). Conclusion: The cognitive-behavioral-therapy-based psychoeducation program positively affects university students in various aspects. After the psychoeducation, the perceived stress levels of the students decreased, their self-efficacy levels were positively affected, and their negative automatic thinking levels decreased.
Designing Multi‐Epitope Subunit Vaccine Candidate for Zika Virus Utilizing In silico Tools
Authors:   Department of microbiology, Faculty of Basic Siences, Lahijan Branch Islamic Azad University, Lahijan, Guilan, Iran., Shams Moattar Fatemeh , Asadzadeh Azizeh ,   Department of biology, faculty of science, Nour Danesh institute of higher education, Meymeh, Isfahan, Iran, Heydari Maryam ,   Department of biology, faculty of science, Nour Danesh institute of higher education, Meymeh, Isfahan, Iran, Zamani Maryam ,   Department of biology, faculty of science, Nour Danesh institute of higher education, Meymeh, Isfahan, Iran, Esnaashari Fatemeh ,   Department of microbiology, Faculty of Basic Siences, Lahijan Branch Islamic Azad University, Lahijan, Guilan, Iran., Jeldani Fatemeh ,   Department of microbiology, Faculty of Basic Siences, Lahijan Branch Islamic Azad University, Lahijan, Guilan, Iran.
Published: March 2023

Background: The arboviruses Zika virus (ZIKV) is a pathogen that threatens human health. Scientists have warned that a single mutation in the mosquito-borne ZIKV could spark another major outbreak of the disease in humans. Therefore, designing a suitable vaccine for this virus seems necessary. This study aimed to predict the protective epitopes of envelope protein from the Zika virus with bioinformatics methods for multi-epitope vaccine development. Materials and Methods: Computational studies including the identification of potential B-cell and T-cell epitopes were used. For generating a multi-epitopic vaccine construct (MEVC), selected epitopes are connected by suitable linkers. To enhance protein immunogenicity, Maltosebound protein was added to the MEVC after the prediction and refinement of the 3D structure of the designed vaccine. The binding mode of the MEVC with toll-like receptor was investigated by molecular docking technique. Finally, molecular dynamics and in silico cloning were performed for the designed vaccine. Results: This study showed that this recombinant vaccine is nontoxic, nonallergenic, and thermostable and elicits immune responses against the Zika virus. Conclusion: The computational data suggest that the MEVC has appropriate characteristics and a high-quality structure.
MODEL FOR CALCULATING THE RELIABILITY OF SAMPLES OF KINEMATIK PAIRS OF MACHINE-ROBOTS
Authors:   Odesa Polytechnic National University, Yahlinskyi V. P. , Hutyria S. S. ,   Odesа Polytechnic National University, Vovk V. V. ,   Odesа Polytechnic National University
Published: March 2023

In the article, the reliability issues of machine tool mechanisms are still more at the stages of pre-project studies and experimental tests. In connection with the introduction of highly effective technological processes, systems of automated design and production, complex systems that provide a high level of labor productivity, the requirements for reliability, durability and workability are constantly growing. Failures of mechanisms in the composition of robotic machines, in accordance with their physical nature, can be associated with the destruction of nodes and details of mechanisms and their drives, jamming of individual elements and other reasons that lead to the fact that the technological equipment becomes unable to perform its functions. Rice's formula was used to determine the average parameter of the flow of rejections. To estimate the average parameter of the flow of failures, it is necessary to know the density of the joint distribution of the state parameter and the rate of its change over time. In many cases, such processes are described by a stationary random function with a normal law of distribution of both the state parameter and the rate of its change. Parametric failures precede functional failures, and can also cause them. Sudden failures are considered in a quasi-static formulation as the process of a random sequence of parameters exceeding the permissible limits in space. It is proposed to carry out the reliability study in the following three main stages: construction on the basis of theoretical or experimental studies of the dependence of the initial parameter on load indicators; thorough statistical analysis of operating conditions, probabilistic description of load indicators; construction of the distribution of the initial parameter. The algorithm for calculating system reliability indicators is presented, the initial parameter of which is presented in the form of a random sequence, imitating the work of a certain number of samples of the machine-work kinematic pair in real operational conditions up to their complete wear. The initial basic size and criterion parameter for each sample are determined by the Monte Carlo method.
ANALYSIS OF WAVELET TRANSFORMATION METHODS IN IMAGE COMPRESSION PROBLEMS
Authors:   State University of Intellectual Technology and Communications, Solodka V. I. , Tymoshevskyi O. V. ,   State University of Intellectual Technology and Communications
Published: March 2023

In this work, an analysis is carried out using spectral transformations to obtain compression indicators and signal-to-noise ratio, the best wavelet basis, namely, a special case of the Fourier transform for image compression according to the signal-to-noise ratio criteria. The increase in the compression ratio with increasing Dobeshi order is shown due to the fact that increasing the order increases the scaling function, which allows to increase the degree of compression of the image, obtaining a satisfactory quality of this image. But with increasing scaling function, the length of the filter increases, which complicates the implementation of this method. Spectral transformations in the problems of image compression in modern algorithms are shown that they can increase the compression ratio of black and white and color images with a comparative visual quality in relation to the algorithms of the previous generation, based on discrete cosine transform. Also, the design of a mesh volumetric object in two-dimensional coordinates is carried out to remove invisible vertices and segments. A study of the transfer of the remainder in the two-dimensional field of vertices during alternation and sequential television scans. It is shown that in order to reduce the data flow, it is advisable to perform a spectral wavelet transform before transforming a three-dimensional grid image into a two-dimensional one. By removing insignificant values of the wavelet coefficients, it is possible to achieve compression by a factor of 5, while the image quality represented by the signal-to-noise ratio reaches 35 dB – an estimate of the indicator of acceptable visual quality for comfortable viewing.
QUALITY CONTROL TOOLS VISUALIZATION IN THE PDCA CYCLE BY MEANS OF INFORMATION AND COMMUNICATION TECHNOLOGIES
Authors:   Kharkiv National University of Radio Electronics, Moshchenko I. O. , Nikitenko O. M. ,   Kharkiv National University of Radio Electronics, Kozlov Yu. V. ,   Kharkiv National University of Radio Electronics
Published: March 2023

The relevance of developing software tools based on traditional quality control methods for analyzing and visualizing the statistical information during the implementation of the PDCA cycle was shown. Guidelines for the use of statistical quality control tools contained in ISO international standards was presented. The quality control tools were analyzed in terms of the obtained statistical results features and the needs for their visual interpretation. The advantages and disadvantages of Сomputer algebra system (CAS) Maple, Matlab, MathCad, Mathematica are given in terms of the availability of random data processing and qualitative statistical results visualization. Based on the analysis of statistical data obtained by quality control tools, it has been proved that it is possible to most effectively solve the task using CAS Maple and the LaTeX publishing system combination. At every stage of the PDCA cycle the software modules for seven basic quality tools were realized using the CAS Maple and the LaTeX publishing system. The computational experiment results were presented. The parameters for the computational experiment results visualization of the using the LaTeX publishing system for their presentation as a single document in the cross-platform PDF format have been determined. A complex model for processing and visualizing statistical information in the PDCA cycle using the CAS Maple and LaTeX system has been developed. The model takes into account the peculiarities of input statistical information and visual interpretation of each basic quality tool. The model allows getting a single file in PDF format at the output. This PDF file contains a complex analysis of the technological process quality in a form that is simple for visual perception. Using the comparative analysis method, an expert map was compiled, that analyzed the advantages and disadvantages of each quality control tool. General recommendations were given on the use of the developed modules during the realization of the PDCA cycle in practice in the process of quality control in production and in the educational process of the engineering students.
SPECTRAL ANALYSIS OF VIBRATION SIGNAL USING FOURIER TRANSFORM
Authors:   National Aviation University, Kvasnikov V. P. , Stakhova A. P. ,   National Aviation University
Published: March 2023

The paper analyzes the topical issue of timely detection and prevention of a dangerous state of critical machines and mechanisms using vibration diagnostics as a promising method. It is proposed to use the method of analysis of vibration spectra in order to identify malfunctions, by processing the output signal from the sensor, which is sent to a personal computer, where a spectral analysis of the measured vibration signal is performed using a diagnostic program based on MATLAB. It is proposed to use spectral analysis, which is a traditional method of vibration diagnostics. It is supposed to determine the faulty state according to vibration measurement data and then to determine the nature of the fault according to the vibration signals analysis using the Fourier transform. It is proposed to process the output signal from the vibration sensor to a personal computer, where a spectral analysis of the measured vibration signal is carried out using a diagnostic program based on MATLAB. The use of FFT algorithms is due to a decrease in the number of operations performed, and, consequently, an increase in performance. It is shown that the decomposition of a complex signal in a Fourier series gives the components of the spectrum, which are, in narrow-band analysis, the harmonic components of the complex signal. It has been determined that narrowband spectral analysis allows detecting a larger number of faults or defects and is used for monitoring and in-depth diagnostics of equipment. Knowing the frequencies at which malfunctions of the kinematic pairs of machinery are manifested, the amplitude of the spectrum components can be used to assess their state. It was determined that spectral analysis is widely used in the processing of vibration diagnostics data, being the main and classical method of analysis. To optimize the duration of the test, it is necessary to take into account the relationship between the spectrum bandwidth and the signal accumulation time. The pass-through characteristic reflects the dependence of the signal level on time at a certain frequency, illustrating the process of signal accumulation during narrow-band spectral analysis. The narrower the analysis strip, the longer the measurements take.
Immunomodulatory Effects of Phaleria macrocarpa Leaf Extract in Normal And Cyclophosphamides Induced in Wistar Rats
Authors: Febriady Andy , Harahap Urip , Yuandani Yuandani
Published: March 2023

Abstract. Cyclophosphamide is an antineoplastic drug belonging to the alkylating agents commonly used in treating cancer. However, the use of cyclophosphamide causes a decrease in the body's immune system by reducing lymphocyte proliferation. The curent study was conducted to evaluate the immunomodulatory effect of ethyl acetate extracts of the leaf of the P. macrocarpa (EEADMD) and the ethanol extracts of the leaf of the P. macrocarpa (EEDMD) in normal and cyclophosphamide induced rats. This study used rats classified into two major groups: normal rats and rats induced by cyclophosphamide which were then given P. macrocarpa leaf extract until day 14. On day 4, the test animals were infected with 1% Staphylococcus aureus suspension in. Induced with cyclophosphamide 70 mg/kg BW was carried out on the 8th and 13th days, and then the immunomodulatory activity was tested using total leukocyte analysis, leukocyte differential, and delayed type hypersensitivity response. The results showed that EEDMD 400 mg/kg BW  in normal rats and EEDMD 100 mg/kg BW in cyclophosphamide induced rats could increase total leukocytes and leukocyte differential with a significant difference to the negative group (p <0.05). The results of the delayed hypersensitivity response test of EEADMD and EEDMD at a dose of 100 mg/kg BW with cyclophosphamide induction and normal rats could give an increase in rat paw volume with a significant difference to the negative group (p <0.05). This study shows that EEADMD and EEDMD have an immunomodulatory effect on increasing total and differential leukocytes and leukocyte differential and delayed type hypersensitivity response.
ОЦІНКА БАКТЕРИЦИДНОЇ ТА ФУНГІЦИДНОЇ АКТИВНОСТІ СІРКОВМІСНИХ 2,3-ДИГІДРОІМІДАЗО[2,1-b]ТІАЗОЛІВ
Authors: САЛІЄВА Леся , СЛИВКА Наталія , МАРУШКО Лариса , КОМАРОВСЬКА-ПОРОХНЯВЕЦЬ Олена , ТОЛМАЧОВА Валентина , КОВАЛЕНКО Наталія , ВОВК Михайло
Published: March 2023

Імідазо[2,1-b]тіазоли належать до привілейованих гетероциклічних систем та користуються підвищеною увагою дослідників, що обумовлено їх потужним медико-біологічним потенціалом. З метою пошуку неток- сичних антимікробних засобів видавалось доцільним вивчити бактерицидну та фунгіцидну активність сір- кофункціоналізованих імідазо[2,1-b]тіазолів. Модельні об'єкти, S-(тетрагідроімідазо[2,1-b]тіазолілметил) тіоацетати 2a,b, О-бутил S-(тетрагідроімідазо[2,1-b]тіазолілметил)карбонодитіоати 3a-d та 6-(пропан-2-іліден)-2-тіоціанатометилімідазо[2,1-b]тіазолон 4, були синтезовані реакцією нуклеофільного заміщення ато- мів брому та йоду у 2-галогенометил-2,3-дигідроімідазо[2,1-b]тіазолонах на тіоацетатну, бутилксантогенатну та тіоціанатну функції. Результати проведеного біоскринінгу засвідчили, що досліджувані сполуки характеризуються помірною бактерицидною та фунгіцидною активностями, які оцінювали за величинами зон пригнічення росту тест-культур, а також за величинами мінімальної інгібуючої концентрації (МІК) і мінімальної бактерицидної концентрації (МБК) методом серійних розведень. Встановлено, що найкращою антимікробною та протигрибковою дією відзначається 6-(пропан-2-іліден)тіоцетат 2b, який за концентрації 0,5% пригнічує ріст бактерій Micrococcus luteus в діаметрі 12 мм та грибів Aspergillus niger в діаметрі 13 мм. При визначенні мінімальної бактеріостатичної концентрації (МБсК) та мінімальної фунгістатичної концентрації (МФсК) сполук 2-4 методом серійних розведень встановлено, що вони виявляють протимікробну дію в концентраціях 15.6-500 мкг/мл. Знайдено, що О-бутил S-(6-бензилідентетрагідроімідазо[2,1-b]тіазолілметил)карбонодитіоат 3d в концентрації 31.2 мкг/мл проявляє інгібуючу активнісь проти Micrococcus luteus, а 6-(пропан-2-іліден)-2- тіоціанатометилімідазо[2,1-b]тіазолон 4 – проти Candida tenuis вже за концентрації 15.6 мкг/мл.
КРИСТАЛІЧНА СТРУКТУРА Ce1.5Tb1.5Ga1.67S7
Authors: БЛАШКО Назарій , МАРЧУК Олег , ФЕДОРЧУК Анатолій , РОМАНЮК Ярослав
Published: March 2023

В роботі представлено результати дослідження кристалічної структури Ce1.5Tb1.5Ga1.67S7 як перспективного матеріалу, що прогнозовано може володіти цікавими нелінійно-оптичними властивостями. Синтез зразка стехіометричного складу Ce1.5Tb1.5Ga1.67S7, загальною масою 0.8 г, отримано сплавлянням простих речовин у вакуумованому кварцевому контейнері до залишкового тиску 10 -2 Па за максимальної температури синтезу 1100 °С. Кристалічна структура Ce1.5Tb1.5Ga1.67S7 (a = 10.0316(4) Å, c = 6.0640(4) Å, V = 528.48(6) Å3, RI = 0.0498, Rp = 0.1553) вивчена рентґенівським методом порошку. Встановлено приналежність структури синтезованого сульфіду до гексагональної сингонії (структурний тип La3CuSiS7, просторова група P63; символ Пірсона hP24). Сульфід Ce1.5Tb1.5Ga1.67S7 синтезований на основі La3Ga1.67S7 шляхом заміщення атомів лантану в правильній системі точок 6с атомами статистичної суміші M (0.5 Ce + 0.5 Tb). Елементний склад зразка Ce1.5Tb1.5Ga1.67S7 (Ce: 7.56 ± 1.34%; Tb: 16.82 ± 3.18%; Ga: 15.93 ±1.44 %; S: 59.70 ± 3.07 %) підтверджено EDAX-аналізом. У структурі дослідженого тетрарного сульфіду атоми статистичної суміші M (0.5Ce + 0.5Tb) локалізовані в ПСТ 6с і разом з атомами сульфуру формують тригональні призми, що мають один додатковий атом [M 3S13S21S3]. Тригональні призми утворюють “блоки” 3[M 7S]. У цих “блоках” тригональні призми між собою з’єднані ребрами. Із-за незначного індексу спотворення (розрахований за довжинами зв’язків) ефективне координаційне число атомів статистичної суміші M (0.5 Ce + 0.5 Tb) становить 6.84. Атоми Ga1 (заповнення 0.667), що сконцентровані в ПСТ 2а, формують октаедри [Ga1 6S1]. Ці октаедри між собою з’єднані гранями та в напрямку осі с утворюють колони. Введення у структуру La3Ga1.67S7 атомів статистичної суміші спричинює значне спотворення октаедрів [Ga1 6S1]. В ПСТ 2b атоми Gа2 оточені чотирма атомами cульфуру [Ga2 3S21S3]. Незначний індекс спотворення (0.017 (розрахований за довжинами зв’язків)) тетраедрів свідчить про їх високу симетричність (ефективне координаційне число рівне 3.93).
Melatonin: A review of its physiopathological and therapeutic relationship with parasitic diseases
Authors: Cardenas Ricardo Jose , Chacin-Bonilla Leonor , Bonilla Ernesto
Published: March 2023

Melatonin (MEL), an indoleamine hormone synthesized in almost all organisms including humans, has been the object of a considerable body of research due to its pleiotropic functions. Recently, focus has been given to its roles as a regulator of the immune and inflammatory response, in the context of numerous disorders; likewise, it has been studied as a potential therapeutic option in numerous infectious diseases. In this sense, the relationship between this molecule and parasitic infections is of particular interest; thus, the present review aims to compile knowledge acquired in the last few years, regarding the participation of MEL in the pathophysiology of parasitic infections, and its potential clinical applications. Since parasitic diseases still represent a significant burden on health systems worldwide, particularly in low and lower-middle income countries with limited access to sanitation facilities and resources for therapeutic approaches, the continuing study of MEL, as an affordable and fundamentally safe healing option, might help better control of these infections.
Melatonin attenuates cardiac injury caused by chromium-mediated oxidative stress in male Wistar rats: involvement of antioxidative mechanisms
Authors: Ghosh Priyanka , Dey Tiyasa , Majumder Romit , Datta Madhuri , Chattopadhyay Aindrila , Bandyopadhyay Debasish
Published: March 2023

Cardiovascular disease (CVD) is a global health concern due to its high mortality. Heavy metals are the potential risk factor for CVD. Among other heavy metals, chromium (Cr) is considered a serious threat to human health due to its high oxidative capacity. In the current study, male Wistar rats were treated with Cr to induce cardiac tissue injuries, meanwhile, melatonin was given to test whether this treatment can protect against Cr-induced cardiac damage. The results showed that Cr markedly altered the heart weight, biomarkers of oxidative stress, activities of antioxidant and pro-oxidant enzymes, as well as tissue morphology. On contrary, melatonin treatment significantly suppressed all these alterations via its antioxidant activity. In addition, melatonin also significantly reduced tissue Cr concentration probably through its metal-chelating activity. The current study has demonstrated that melatonin is a promising antioxidant to protect the heart from Cr-induced oxidative damage, confirming that melatonin can be a future therapeutic agent for Cr-mediated toxicity in the heart or other organs.
PERANCANGAN BUKU PANDUAN PENDAKIAN GUNUNG ARJUNO VIA TAMBAKSARI SEBAGAI MEDIA INFORMASI
Authors: Ardiansyah Sonny , Yani Aditya Rahman , Chidtian Aileena Solicitor Costa Rica El , W Wulan
Published: March 2023

Indonesia merupakan wilayah yang masuk dalam jalur cincin api pasifik, mulai dari Sumatera, Jawa, Bali, Sulawesi, dan Papua. Terdapat kurang lebih 400 gunung, sekitar 130 gunung yang masih aktif. Masing-masing gunung memiliki karakteristik yang berbeda-beda, dan juga menyimpan potensi wisata alam karena memiliki keindahaan dan kekayaan alam. Akan tetapi pada masa pandemi ini, banyak wisata alam yang ditutup. Salah satunya wisata pendakian gunung, salah satunya terjadi di gunung Arjuno. Kemenparekraf sudah berupaya menyiapkan untuk meningkatkan kompetensi pada era new normal di wisata alam, salah satunya  pelatihan instruktur pemandu wisata gunung. Program pelatihan yang akan dilaksanakan antara lain menyusun program pelatihan, desain media pembelajaran, penyajian materi pelatihan, dan melakukan pelatihan secara tatap muka.
Compactability of Agro based Geopolymer using Sodium Silicate Activator
Authors: Agashua Lucia Omolayo , Ogbiye Samuel Adebanji , Amu Olugbenga Oludolapo , Igibah Christopher Ehizemhen
Published: March 2023

The strength of a fine-grained lateritic soilfrom three (3) different localities on Abuja – Lokoja road where road failure happen was treated with rice husk ash (RSA), cement andsodium silicate activator (SSA), with varying percentage examined by means of Atterberg, Compaction and triaxial shear tests. The addition of optimum cement with additives changes laterite sample of plasticity index (PI) into non-plastic and resulted in a minimum of 11.90 % reduction in PI of lateritic soil which led to the belief that additives decreases plasticity of soils, and this is an advantage, because reduction in PI contents indicates animprovement.Thecompaction characteristics of the natural lateritic soils were altered with the addition of optimum contents of OPC with each of RHA, KCP and SSA. The MDD of cement-stabilized residual soil slightly increased with the increase in cement content, whereas by adding RHA, KCP and cement, the OMC is decreases steeply. Also, CBR results shows that CBR of the soil-cement-SSA content increases upon adding sodium silicate activator content up to 4% SSA content before the value experiences reduction at much higher SSA content. But, theRHA-treated residual soils decrease the CBR value from 6% upwards. This, again, alludes that RHA alone is not suitable as stabilizer.