bluuebunny/crossref_metadata_2025 huggingface dataset:
Selected toxicological aspects of honey
Authors: Šramková Katarína Fatrcová , Kačániová Miroslava
Published: January 2021

The aim of the present review was to analyze grayanotoxin and its healthy and poisoning effect to human health according to available resources of literature. Plants contain many compound components which can be categorized as "medical" or "poisonous" depending on their effects to human body.  There are also secondary products derived from plants, such as honey, which can contain many chemical compounds with medicinal or poisonous effects depending on their concentration and application. Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. The consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, hypotension and atrial-ventricular block.
ANALISIS PENGARUH PERSPEKTIF-PERSPEKTIF BALANCED SCORECARD TERHADAP KINERJA PERUSAHAAN PADA PERUSAHAAN DAERAH AIR MINUM KARANGANYAR
Authors: Saryanti Endang , Tiningrum Erna
Published: January 2021

ABSTRAKPenelitian ini dilaksanakan untuk memberikan bukti bahwa perspektif-perspektif dalam balanced scorecard secara simultan dan parsial berpengaruh terhadap kinerja perusahaan pada Perusahaan Daerah Air Minum Karanganyar. Penelitian ini dilakukan dengan responden karyawan perusahaan dalam menilai kinerja perusahaan yang beralamatkan di Komplek Perkantoran Cangakan Karanganyar 57712. Populasi dalam penelitian ini 95 responden, tetapi hanya 88 sampel yang sempurna. Data dalam penelitian ini diperoleh melalui kuesioner yang dikirimkan pada responden penelitian dan data sekunder, yang diperoleh dari literature-literatur atau data yang mendukung.Teknik analisis data yang digunakan uji validitas, reliabilitas, analisis regrisi linier berganda, ujiasumsi klasik, uji t, uji F, dan koefisien determinasi. Hasil analisis regresi linier berganda menunjukan perspektif keuangan berpengaruh negatif terhadap kinerja perusahaan, perspektif pelanggan, proses bisnis internal, pembelajaran dan pertumbuhan berpengaruh positif terhadap kinerja perusahaan. Uji F yang dilakukan menunjukan terdapat pengaruh positif dan signifikan perspektif keuangan, perspektif pelanggan, perspektif proses bisnis internal, perspektif pembelajaran dan pertumbuhan secara simultan terhadap kinerja perusahaan pada PDAM Karanganyar. Hasil Uji t menunjukan perspektif keuangan berpengaruh negatif tidak signifikan terhadap kinerja Perusahaan Daerah Air Minum Karanganyar. Perspektif pelanggan berpengaruh positif tidak signifikan terhadap kinerja Perusahaan Daerah Air Minum Karanganyar. Perspektif proses bisnis internal berpengaruh positif signifikan terhadap kinerja Perusahaan Daerah Air Minum Karanganyar. Perspektif pembelajaran dan pertumbuhan berpengaruh positif tidak signifikan terhadap kinerja Perusahaan Daerah Air Minum Karanganyar. Hasil koefisien determinasi menunjukan bahwa perspektif keuangan, pelanggan, proses bisnis internal, pembelajaran dan pertumbuhan dapat menjelaskan kinerja perusahaan sebesar 26,4% dan sisanya dijelaskan oleh variabel lain yang tidak diteliti. Kata Kunci: Kinerja Perusahaan,Perspektif Keuangan, Perspektif Pelanggan, Perspektif Proses Bisnis Internal Serta Perspektif,Pembelajaran Dan Pertumbuhan.
FLUKTUASI INDEKS SAHAM GLOBAL YANG PERLU DIPERHATIKAN UNTUK TRADING SAHAM SEKTOR FINANCE DI INDONESIA
Authors: Murti Nugroho Wisnu , Widyastuti Indriyana , Rahayu Saptani
Published: January 2021

ABSTRAKPenelitian ini dikembangkan tidak hanya memberikan pertimbangan pada investasi saham pada dengan mempertimbangkan fluktuasi indeks saham internasional.Akan tetapi juga melakukan analisis pada Informasi ini penting untuk mempertimbangkan investasi saham yang lebih fokus pada sektor tertentu karena beberapa penelitian terdahulu yang lebih banyak memberikan pertimbangkan alternative investasi dengan melakukan analisis pada indeks harga saham gabungan. Data yang digunakan adalah data time series fluktuasi harga saham mingguan indeks harga saham internasional antara lain Dow Jones 30, Hangseng, Nikkei, dan Strait Times dari tahun 2008 sampai dengan 2018 yang diestimasi untuk memprediksi pergerakan indeks harga saham finance indonesia. Penelitian ini menemukan bahwa beberapa indeks internasional yang diobservasi memiliki hubungan yang kuat dengan fluktuasi indeks saham finance Indonesia. Akan tetapi arah hubungan tersebut berbeda-beda. Akan tetapi informasi yang lebih harus diketahui adalah hampir semua indeks tersebut memilikibeda yang signifikan antara indeks internasional ketika diestimasi dalam model yang memiliki efek terhadap reaksi pada pasar modal di Indonesia. Temuan tersebut memberikan implikasi praktis bahwa ketika investor memperhatikan indeks internasional untuk memprediksi arah reaksi pasar modal Indonesia, indeks – indeks tersebut perlu diperhatikan semuanya secara spesifik. Penelitian ini mengidentifikasi dalam enam perbedaan antara dua indeks internasional terhadap pergerakan indeks finance Indonesia.
THE EFFECT OF TAX INFORMATION SOCIALIZATION AND TAX KNOWLEDGE ON TAXPAYER COMPLIANCE WITH TAXPAYER AWARENESS AS MEDIATION VARIABLES
Authors: Hasian Purba
Published: January 2021

The purpose of this study are as follows: 1) Finding empirical evidence regarding the effect of Tax Socialization on Taxpayer Awareness; 2) Finding empirical evidence regarding the effect of Tax Knowledge on Taxpayer Awareness; 3) Finding empirical evidence regarding the effect of Tax Socialization on Taxpayer compliance; 4) Finding empirical evidence regarding the effect of Taxation Knowledge on Taxpayer compliance; and 5) Finding empirical evidence regarding the influence of Taxpayer Awareness on Taxpayer compliance. This type of research used in this study is causal which will test the hypothesis about the effect of one or several independent variables on the dependent variable. The population in this study are all individual taxpayers who are registered in Jakarta Kramatjati Tax Office. Sample selection with convenience sampling method. The analytical method used to test hypotheses is the path analysis test and multiple test. The results showed that: 1) Tax socialization has a direct effect on the awareness of taxpayers; 2) Tax knowledge directly affects the awareness of taxpayers; 3) Tax socialization directly affects the compliance of taxpayers; 4) Tax knowledge directly affects the compliance of taxpayers; and 5) Taxpayer awareness directly influences taxpayer compliance.

KEYWORDS : Taxation Socialization, Taxation Knowledge, Taxpayer Awareness, Taxpayer Compliance
Optimization Of Natural Ventilation In Building As Passive Design Strategy For Health Security
Authors: Cynthia Permata Dewi
Published: January 2021

The use of natural ventilation strategy in a building is currently encouraged by the emergence of a pandemic Covid-19. In addition to its advantages in minimizing the use of electrical energy, the natural ventilation system is believed could reduce the possibility of spreading the virus. One design approach to this system is by using the window's design properly. Air movement inside a building should be utilized well to allow the movement from inlet to outlet. The position of the window was one of the variables examined in this study besides the types of the window. This study found that the use of a combination of 300 awnings produced the highest airspeed in the living room (R1), while a combination of horizontal sliding windows resulted in the highest air velocity in the bedroom (R2). Still, the airspeed generated from the two combinations less than the minimum level of it is generally required, 0.75 – 0.9 m/s.
Study of Adaptive-Reuse Application in Rumah Atsiri (Ex. Citronella Factory), Karanganyar
Authors: Rakhmanty Febrione Putri , Krisnawati Eny
Published: January 2021

Abandoned and unused old buildings are often seen as a waste of land. One of the ways that old buildings can be reused is to use the adaptive-reuse concept, which is an attempt to reuse an old, unused building into a different function from the original function while maintaining the original building values. The purpose of this research is to understand how the Adaptive Reuse concept is applied in Rumah Atsiri Indonesia. Firstly, the data has been collected through literature survey and field survey. Then, analyzed the elements of Rumah Atsiri Indonesia that can be categorized as adaptive reuse examples and have been investigated in the light of the de?ned factors. At the end, according to the result we can find what kind of work that has been done in Rumah Atsiri Indonesia that makes it as a sample of adaptive reuse projects. Rumah Atsiri that we see today is the result of the revitalization of an old factory building with a touch of modern architecture. Revitalization is carried out while maintaining the authenticity of the design of the building. The contrass of materials makes visitors able to distinguish which of the old buildings and which buildings and new elements are added by looking at the materials used.
Evaluation of the Frequency of Pain Occurrence of the Lumbar Spine Measured in the Employees of Szczecin’s Universities Depending on Age and Pathomechanisms
Authors: Jagucka-Mętel Wioletta , Baranowska Agata , Ciosek Żaneta , Sobolewska Ewa , Lietz-Kijak Danuta , Bulsa Marek
Published: January 2021

Introduction: With age, there are many pathologies in the organs of our body. The sedentary lifestyle in specific professional groups cause the emergence and intensification of functional and structural defects of the spine.
Aim: The aim of the study was to examine the frequency of pelvic and lumbar spine disorders (measured using functional tests and imaging tests) affecting the frequency of pain.
Material and Methods: The study involved 114 patients with lumbosacral pain (75 women, 39 men, 24-85 years of age, average age of the respondent 53 years). It was carried out between July 2017 and September 2019 at SP ZOZ SW in Szczecin. In the study group, the author’s questionnaire was used, functional tests were carried out and imaging analysis was performed.
Results: The frequency of occurrence of pain episodes depends statistically significantly on the age (p <0.05). The highest percentage of frequent pain occurs in people over 65 years of age (70.83%). Over half (57.02%, n = 65) of respondents struggle with pain in the ilio-lumbar and / or sacro-tumor ligaments. Strong pain in the ilium-lumbar ligament is statistically significant in people with lumbar hyperlordosis (84.62%, n = 22). This relationship was also observed during the lifting of hands. For 6 people declaring the pain while doing this - 4 of them also show severe pain in the ilio-lumbar ligaments. The pain of the cruciate ligament alleviates the standing position, which is also statistically significant. In the employees of the Szczecin universities, the disc herniation of the intervertebral disc was most often found in people between the 4th and 6th decade of life. Pain discomfort associated with discopathy accompany patients throughout all day (p <0.05).
Conclusions: The degree of advancement of changes in the lumbar-sacral spine increases with age. The type of lumbar lordosis affects pain in the ilium-lumbar ligament.
The Evaluation of the Changes In Blood Pressure and the Heart Rate
in the Course of Applying Pearl Bath at Persons With the Normal Blood Pressure and Heart Rate
Authors: Kochański Wiesław J. , Kochański Maciej , Frankowska Adrianna
Published: January 2021

Aim: The aim of this study was to investigate the effect of pearl bath on basic parameters of the cardiovascular system in patients without hypertension
Material and Methods: This study recruited 40 patients without hypertension (20 male and 20 female). All patients had their blood pressure and heart rate measured immediately before and during the procedure.
Results: During the pearl bath HR increased by an average of 2.6 bpm (p=0,018355), and from the measurement before surgery by 5.5 bpm (p=0,000404). SBP decreased during the bath by 8.7 mmHg (p=0.000001), DBP by 4.8 mmHg (p=0,000727). SBP, DBP values for pre-treatment measurements decreased by 14.4 mmHg (p=0,000000) and 9.7 mmHg (p=0,000005), respectively.
Conclusions: Pearl baths decreases blood pressure and increase pulse. The dynamics of changes in systolic blood pressure, diastolic blood pressure and heart rate do not differ significantly between male and female.
Analysis of Physical Therapy in Knee Osteoarthritis
Authors: Kuliński Włodzisław , Siołek Agnieszka
Published: January 2021

1,2, 1
1,2
1Department of Rehabilitation, Military Institute of Medicine, Warsaw, Poland

Introduction: Osteoarthritis (OA) is the most common disorder of the musculoskeletal system. It is characterised by the destruction of joint cartilage and the presence of lesions in the subchondral bone, synovial membrane, joint capsule, and periarticular structures. OA damages the anatomical joint structure and impairs joint function.
Aim: To analyse the effects of physical therapy procedures used during a two-week rehabilitation cycle on patients with OA.
M
aterial and Methods: The study involved 25 patients (19 women and 6 men aged 51 to 83 years) treated with electrotherapy, laser therapy, low-frequency alternating magnetic fields, ultrasound therapy, and kinesiotherapy. Rehabilitation outcomes were assessed with
a survey questionnaire created by the authors and a VAS scale.
Results: All study patients experienced pain reduction or elimination and an improvement in physical fitness after physical therapy.
Conclusion: 1.Knee osteoarthritis is a clinical and social problem. 2. The physical therapy procedures used in the study considerably reduced pain in OA patients, both at rest and during movement, and resulted in improved physical fitness. 3. Seeing that a very large group of study patients with gonarthrosis declares no physical activity and avoids exercise due to pain, it is important to highlight the benefits of physical activity in OA prevention. 4. Seeing that the mean BMI in the study group usually indicated overweight or obesity, it is important to highlight the effects of a healthy lifestyle and diet in OA prevention.
Rehabilitation of Patients with Long-Term Complications
of Mild Closed Traumatic Brain Injuries Using Sensory Deprivation
Authors: Korshnyak Volodymyr O. , Donnik Tetyana A.
Published: January 2021

Introduction: This study’s primary goal was to develop and implement a new non-pharmacological method of therapy to increase the effectiveness of rehabilitation treatment of patients with long-term complications of mild closed traumatic brain injuries.
Material and Methods: We examined 100 patients with complications of mild closed traumatic brain injuries in the stage of decompensation. We studied the dynamics of subjective and objective neurological symptoms, vegetative indices (vegetative tonus, vegetative responsiveness, vegetative provisioning), and neuro mediators levels (adrenaline, noradrenaline, serotonin, dopamine, and melatonin) before and after sensory deprivation.
Results: During rehabilitation, we observed the positive changes in neurological status as well as in the balance restoration of the nervous system and the neurohormonal normalization of the sympathoadrenal system. It contributed to a more adequate generalized adaptive response of the body. After a series of rehabilitation procedures, the difference between the maximal and control markers of melatonin excretion significantly decreased, which might confirm the evidence of normalization of the processes’ rhythmicity and vital functions, as well as the improvement of complex neuroprotection. Also, the normalization of melatonin excretion in patients was associated with sleep improvement, decreased intensity of the headache syndromes, and increased activity and ability to act.
Conclusions: Long-term complications of mild closed traumatic brain injury develop due to activity imbalance of supratentorial structures of the vegetative nervous system, desynchronization of the cortex’s activity, and desynchronization of humoral mechanisms of vegetative activity realization. The use of sensory deprivation promotes much faster rehabilitation of this group of patients, reduces the pharmacological burden on the patient’s body, and improves the brain system’s functioning.
Effects of Prophylactic Use of a Decoction of Blueberry Leaves
in Modeling the Lesion of the Gastrointestinal Tract by Non-Steroidal Anti-Inflammatory Drugs
Authors: Pachevska Alisa V. , Biloshitska Alina V. , Istoshyn Valery M.
Published: January 2021

Introduction: Today there is a continuing search for an effective, affordable remedy that can be used to treat and prevent diseases of periodontal, stomach and duodenum during the use non-steroidal anti-inflammatory drugs ( NSAIDs ).
Aim: To study the protective effect of phytopreparation (decoction of blueberry leaves) on an experimental model of gastric ulcer and periodontitis.
Material and Methods: The study was performed on 30 rats, which were evenly divided into three groups: 1 – control animals, 2 – animals that were modeled with non-steroid gastric ulcer and periodontitis (7 mg/kg diclofenacum natrium intragastrically for 5 days) and 3 – group in the background experimental pathology was introduced decoction of blueberry leaves 1:10 2 ml intragastrically (30 minutes after the introduction of diclofenacum natrium).
Results: Histological examination of the mucous membrane of rats, which used as a preventive agent decoction of blueberry leaves, showed that it is characterized only by single erosion, no fibrinosis and hemorrhagic plaque, lympho-macrophage infiltration.
Conclusions: Simultaneous use of a decoction of blueberry leaves can be used as a preventive and curative agent to prevent the development of erosions and ulcers of the mucous membrane of the digestive system.
Thermal Therapy In Patients with Post-pandemic Stress Syndrome
as a S upporting Therapy
Authors: Ponikowska Irena , Adamczyk Przemysław , Krupka-Matuszczyk Irena
Published: January 2021

The viral pandemic causes multidirectional adverse effects and the greatest of which is health. The viral infection itself and severe infectious disease with pulmonary complications are of government concern. However, less is said about the effects of pandemic restrictions, e.g., social isolation leading to a series of severe psychosomatic disorders. In social isolation and quarantine, the classic negative lifestyle factors are working – the lack of exercise, excessive eating, stress, and addiction intensity. In turn, these factors lead to the exacerbation of chronic diseases such as diabetes, obesity, hypertension, heart disease, and others. Stress plays a unique role as it causes a number of stress syndromes, including the most severe form – post-traumatic stress disorder (PTSD). Stress is destructive to the entire body. It causes changes mainly in the autonomic nervous system and the endocrine system. In a stressful situation, the sympathetic nervous system’s activity increases, which leads to disorders in the functioning of many organs. Together with the autonomic nervous system’s stimulation, the secretion of stress hormones such as adrenaline, noradrenaline, and cortisol increases. Increased adrenaline secretion leads to arrhythmias, hypertension, and metabolic changes. Excessive secretion of cortisol increases protein catabolism, glucagon secretion, increases gluconeogenesis, lipolysis, and, consequently, increases blood glucose and cholesterol levels. Post-pandemic stress syndromes should be treated. Classic psychotherapy proposes the most important methods of treating these syndromes. The thermal therapy is the most useful and of pathogenetic significance. Thermal therapy includes heat therapy, hydrotherapy, peloid therapy, massages, music therapy, and physical training. These procedures, included in the appropriate treatment program, positively affect the autonomic nervous system, reduce the secretion of stress hormones, and reduce the level of stress. Thanks to thermal therapy, patients regain their mental balance, eradicate anxiety, improve physical condition, and increase resistance to infections. Moreover, they acquire knowledge about the proper lifestyle and methods to deal with stress.
Impact of telephone cardiopulmonary resuscitation on the return of spontaneous
circulation in patients with out-of-hospital cardiac arrest
Authors: Jaskuła Jerzy , Niemczyk Karolina
Published: January 2021

The aim: Research aim is the evaluation of return of spontaneous circulation (ROSC) ratio among the individuals with
out-of-hospital sudden cardiac arrest (SCA), depending on the so-called Telephone Cardiopulmonary Resuscitation (TCPR). T-CPR is based on live instruction given by the dispatcher to incident witness, who is performing CPR efforts until the EMS team arrives on scene.
Material and methods: Research was based on the analysis of 782 entries (from EMS documentation) which recorded SCA and CPR. Emergency call voice recording has been rehearsed for each case, in order to confirm the capability of recognizing SCA and providing T-CPR instructions. Data was divided into two groups and the results have been compared. The ROSC ratio for both groups (“T-CPR” and “No T-CPR”) were analyzed along with the type of incident location.
Results: The research has shown that 26,4% of all SCA cases researched ended up with the ROSC. In 94% of cases the dispatcher had succeeded in encouraging the witness to perform CPR with telephone instruction (T-CPR) until the EMS team has arrived. In the “T-CPR” group, 28,7% of cases have ended with ROSC. In the “No T-CPR” group, 19,7% of cases have ended with ROSC (28,7% vs. 19,7%).
Conclusions: The T-CPR should be utilized by dispatcher in the form of uniform protocol. In the process of training dispatchers there should be special emphasis on the skill of recognizing SCA upon receiving a call. The evaluation of SCA recognition, T-CPR undertaken and ROSC ratio may be an effective indicator of quality monitoring within the State Emergency Medical System.
Respiratory tract burns in emergency medical care
Authors: Białoń Piotr , Bobiński Rafał , Mikulska Monika , Kijanka Robert , Szlagor Michał , Ćwiertnia Michał , Ilczak Tomasz , Rak Małgorzata , Stasicki Arkadiusz , Kawecki Marek
Published: January 2021

Respiratory tract burns are among the most serious injuries. Complications include rapid swelling of the respiratory tract, which is the cause of high mortality rates. Such injuries require appropriate specialist treatment. The priority in emergency medical care is to ensure the airways remain unobstructed. If symptoms appear that suggest rapidly increasing swelling of the respiratory tract, intubation becomes essential to ensure the airways remain open. The aim of this article is to discuss the issue of the necessity to develop guidelines for emergency medical personnel attending patients with respiratory tract burns. Currently, according to the State Emergency Medical Care statute, paramedics may carry out intubation on patients suffering from sudden cardiac arrest. According to the Regulation of the Minister of Health of the 20th April 2016, the list of actions that a paramedic may freely undertake does not include intubation of patients with rapidly increasing swelling of the respiratory tract caused by burns. Taking into consideration the decrease in the number of specialist teams, recommendations should be developed as quickly as possible on indications for prompt intubation of patients with inhalation injuries. The scope of emergency medical treatment carried out independently by paramedics should also be expanded.
COMPARATIVE CHARACTERISTICS OF THE PARAMETERS’ CHANGES OF SKIN AND FAT FLEXURES THICKNESS OF EXTREMETIES AT YOUTH UNDER THE CONDITION OF HIGHER EDUCATION
Authors: Alekseyenko Nataliia S. , Andriychuk Vitalii M. , Radoha Ruslan V. , Fomina Lyudmila V. , Fedoniuk Larysa Ya.
Published: January 2021

The aim: To determine and compare annual changes of skin and fat flexures thickness of the extremities of rural and urban youths during training at a university.
Materials and methods: 200 practically healthy young men (100 residents of the village, 100 residents of the city) were studied at the 1st, 2nd and 3rd courses of their education at the University of Life Safety by means of Shephard R. method.
Results: Based on the data we`ve got, the annual reduction of most indicators of the thickness of the fat layer of the upper and lower extremities was supervised. The most substantial decrease was supervised during the first year. The intra-group annual changes were significantly smaller throughout the first year of study, both in the rural and urban groups.
Conclusions: Significant differences in intra-group and inter-group indicators were found between youth living in the city and rural residents. In addition, significant differences were found in the thickness of the skin and fat flexures in youngers of both groups during the three years of education process.
MODERN METHODS OF PATIENTS TREATMENT WITH DENTITION DEFECTS COMBINED WITH FUNCTIONAL DISORDERS OF THE TEMPOROMANDIBULAR JOINT
Authors: Ozhohan Roman , Rozhko Mykola M. , Ozhogan Zinoviy R. , Khopta Roman M. , Miziuk Lidiia
Published: January 2021

The aim: The purpose of the research was to increase the efficiency of treatment at patients with dentition defects and functional disorders of the temporomandibular joint.
Materials and methods: We examined 140 patients aged from 25 to 65 years with functional disorders of the temporomandibular joint, analysed there diagnostic models in the articulator and 3D scanner, used radiographic methods of examination and condylography.
Results: The results of the conducted studies showed that in the 1st group, the biomechanical parameters of temporomandibular joint movements before treatment were significantly lower: 6,4 ± 0,2 mm and 6,8 ± 0,2 mm for right and left temporomandibular joint during protrusion movements; 7,8 ± 0,1 mm and 7,9 ± 0,2 mm during vertical movements; 6,7 ± 0,1 mm and 6,5 ± 0,2 mm during transversal movements. After 12 month of complex and prosthetic treatment with a help of non-removable dentures the magnitude of movements remains at the achieved level at all excursions. As a result, proposed by us comprehensive treatment of functional disorders of the temporomandibular joint is carried out in stages. The proposed design of an individual tire makes it possible to gradually increase the bite height and perfectly forms the occlusal ratio. After 6 and 12 months of the proposed treatment, we have found that the indicators of vertical and protrusion movements of articular heads at patients of 2nd group were significantly better than before treatment.
Conclusions: The proposed design of an individual tire makes it possible to gradually increase the bite height and perfectly forms the occlusal ratio.
PECULIARITIES OF METABOLIC CHANGES IN ASTHMA
Authors: Yeryomenko Galyna V. , Bezditko Tetiana V. , Vysotska Olena V. , Rysovana Liubov M. , Pecherska Anna I.
Published: January 2021

The aim: Revealing of clinical-pathogenetic peculiarities in manifestations of uncontrolled As+MS. Materials and methods: Sixty-five cases, divided into 2 groups: Group I – severe As (n=20), Group 2 – severe As+MS (n=45). The general clinical examination included fasting blood glucose, insulin level, HOMA-IR index, body mass index (BMI), spirometry, levels of ММР-9, МСР-1, IL-8 and IL-12. Results: In Group I, 20 patients (100%) had obstructive respiratory dysfunction. Group II had 13 cases (28.88%) with the restrictive, 15 (33.33%) with the obstructive and 17 (37.77%) with the mixed types. BMI revealed: Group I had the normal mass (BMI averaged 24.62 [22.76; 25.71]; Group II had 21 overweighed cases (46.66%) and 24 (53.33%) with grade 1 obesity, averaging 29.70 [28.35; 31.23]. Correlation analysis in Group II showed significant correlations between: age and WHR (r=0.52, p<0.001) (increase of abdominal fat depots during life), FEV1 and BMI (r=-0.63, р<0.001) (obesity affects pulmonary function). IL-8 and IL-12 levels in Group II were increased, respectively, by 27.86 and 13.18 times versus Group I. A relationship was found between MCP-1 and MMP-9 (r=0.77, р<0.05), Group II revealed direct correlation between MCP-1 and total FEV1 (r=0.53, р<0.05). Conclusions: Overweight and obesity in As+MS deteriorate respiratory function versus the same indices in isolated As. Relationships between proinflammatory cytokines and MMP-9 and MCP-1 prove pathogenetic peculiarities of systemic inflammation and metabolic homeostasis. As and MS can cause their coexistence, facilitating development of mutual aggravation.
FEATURES OF THE COURSE OF PERINATAL INFECTIONS AT THE PRESENT STAGE
Authors: Vygivska Liudmyla A. , Rudenko Lesia A. , Kalnytska Violeta B. , Litvinenko Olena Yu.
Published: January 2021

The aim: To characterize the course of the most common perinatal infections on the basis of assessment of the literature data.
Materials and methods: This article provides an assessment of 125 literature sources submitted to PubMed, Medline, Cochrane Library, CyberLeninka, Google Scholar and
V.I. Vernadsky National Library of Ukraine. The description of the most common viral, bacterial and parasitic perinatal infections, transmission methods, clinical manifestations, methods of diagnosis and treatment, their clinical consequences are described. Perinatal infections are the leading cause of severe congenital pathology, a serious worldwide medical and social problem that needs to be addressed.
Conclusions: Perinatal infections are a serious issue of today, requiring a multidisciplinary approach and the collaboration of doctors of different specialties. Their prevalence among the population, high rates of perinatal mortality, concealment under the mask of other disorders, and the absence of specific clinical symptoms in pregnant and newborns require careful consideration of this problem. Improving the quality of diagnosis and treatment of this pathological condition will help to minimize the risk of transmission of infection, as well as to avoid a number of abnormaalities in the neonatal period and the development of congenital infection.
INSTRUMENTAL MARKERS OF THE RIGHT VENTRICLE FUNCTIONAL CONDITION WITH TISSUE DOPPLER IN CHILDREN WITH TETRALOGY OF FALLOT AFTER SURGICAL CORRECTION AND THEIR CONNECTION WITH VALVULAR FUNCTION OF PULMONARY ARTERY
Authors: Dudnyk Veronika M. , Zborovska Olha O. , Vyzhga Yuilia V. , Popov Vladymyr P. , Bakhnivskyi Valentyn S.
Published: January 2021

The aim: To improve efficacy of the right ventricle functional condition evaluation in children with tetralogy of Fallot after surgical correction by estimation of instrumental markers of myocardial dysfunction.
Materials and methods: We completely examined 35 children with tetralogy of Fallot after their surgical correction at the age of 3 – 17 years. For all the patients was presented tissue doppler. We evaluated peak myocardial velocities of right ventrical in different phases of the heart cycle (S, E`, A`), tricuspid annular plane systolic excursion (TAPSE), diastolic myocardial velocities ratio (E/E`), peak myocardial velocity during isovolumic contraction (IVV), isovolumic relaxation time (IVRT).
Results: All children of the study group had pulmonary insufficiency of different severity with main predominance of mild pulmonary regurgitation (20 patients, 57,14±8,36 %). Children with tetralogy of Fallot after surgical correction were admitted with: decreased TAPSE up to 1,39±0,28 cm, decreased S` up to 8,00±1,90 cm/s, and decreased IVV up to 5,69±0,95 cm/s that is significantly lower results of the healthy children. Severe pulmonary regurgitation usually followed by high chances of the right ventricle systolic dysfunction, exactly with: decresed TAPSE<1,5 cm (OR=0,500; 95% CI 0,323 – 0,775), S`<8,1 cm/s (OR=0,600; 95% CI 0,420 – 0,858) and IVV<5,9 cm/s (OR=0,250; 95% CI 0,117 – 0,534). As well we admitted significant decline of the velocities in earl and end diastole periods to compare with the results of the control group (E`= 12,11±1,22, A`= 4,56±0,92 cm/s (Р=0,009 and P=0.0002)), boost of the E/E` ratio – 7,96±2,33 (P=0.01) and decline of the RV IVRT up to 43,49±6,04 ms (P=0.017). Severe pulmonary regurgitation followed by high chances of the right ventricle systolic dysfunction development with TAPSE <1,5 cm (OR=0,500; 95% CI 0,323 – 0,775), S`<8,1 cm/s (OR=0,600; 95% CI 0,420 – 0,858) and IVV<5,9 cm/s (OR=0,250; 95% CI 0,117 – 0,534). As well we noticed high chances of the E/E`ratio > 6,0 in 1,5 times (95% CI 1,072 – 1,903) and decreased E` <12,2 cm/s (OR=0,200; 95% CI 0,083 – 0,481).
Conclusions: Apart of clinical symptoms of the heart failure in children with tetralogy of Fallot after surgical correction markers of the right ventricle myocardial dysfunction are presented by indices of myocardial velocities, received during tissue doppler in different phases of the heart cycle.
EVALUATION OF BONE RESORPTIVE POTENTIAL
IN THE TREATMENT OF GENERALIZED PERIODONTITIS
Authors: Fastovets Olena O. , Masheiko Ivan V. , Lucash Anna Y.
Published: January 2021

The aim: Is to study dynamics of resorptive potential of bone tissue by indicators of protease and antiprotease systems in the process of treatment generalized periodontitis in patients with age-related osteoporosis and without osteoporotic changes in the skeleton.
Materials and methods: In 102 patients, before the start of treatment of generalized periodontitis and in 2, 4 and 12 weeks, the concentration of pro-resorbing matrix metalloproteinases: stromelysin (MMP-3), collagenase (MMP-8) and gelatinase (MMP-9) were determined in blood plasma and mixed oral fluid. The antiresorbtive potential of bone tissue was evaluated by the concentration of a tissue inhibitor of metalloproteinases (TIMP-1) in plasma. The general antiprotease activity was determined by the activity of α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-MG).
Results: The most significant changes are recorded for the content of MMP-9 in blood and oral fluid, regardless of the presence of systemic disorders of bone metabolism (P < 0.05). Concentration of MMP-8 is significantly increased in blood plasma and oral fluid in accordance with the severity of the disease and in the course of treatment (P <0.05). The observed increase in the ratio of MMP-8 to TIMP-1 and MMP-9 to TIMP-1 in patients with generalized periodontitis, complicated by systemic osteoporosis (P < 0.05), indicates an imbalance of the protease-antiprotease system.
Conclusions: The resorptive potential of bone tissue in patients with generalized periodontitis allows us to correctly choose treatment tactics and to prevent the development of complications.
THE ROLE OF SECRETING FUNCTION OF DECIDUA IN THE DEVELOPMENT OF COMPLICATIONS OF GESTATION PROCESS IN PREGNANT WOMEN WITH A PAST HISTORY
OF CHRONIC ENDOMETRITIS
Authors: Taranovska Olena О. , Likhachov Volodymyr К. , Dobrovolska Ludmyla М. , Makarov Oleg G. , Shymanska Yanina V.
Published: January 2021

The aim: To determine the serum FAMG in the I and II trimester of pregnancy in women with a past history of chronic endometritis, and to clarify its impact on the development of pathology of pregnancy.
Materials and methods: The level of FAMG was determined at 6-8 and 16-18 weeks of gestation in 135 pregnant women with a past history of chronic endometritis, who received treatment of chronic endometritis at the stage of pregravid preparation and 168 women who became pregnant without its prior treatment. The dependence of the development of pre-eclampsia on the level of FAMG at the early stages of pregnancy has been evaluated.
Results: At 6-8 weeks of pregnancy, the level of FAMG in women with a past history of chronic endometritis was 20.6% lower (122.4 ± 7.6 ng/ml) compared to the control group. In FAMG of 90.3 ± 4.3 ng/ml at 6-8 weeks of gestation, spontaneous abortion occurred in 100% of cases within the next 2 weeks. FAMG lower than 122,1 ± 3,0 ng/ml can be the predisposing factor for the development of pre-eclampsia.
Conclusions: Reduced FAMG in the beginning of pregnancy in women with untreated chronic endometritis in the past history increases the incidence of miscarriages at the early stages by 2.6 times, and by 1.8 times the probability of preeclampsia development. Treatment of chronic endometritis at the stage of pregravid preparation promotes the increase of FAMG by 24,6% compared to untreated women that reduces the probability of complications during the subsequent course of pregnancy.
THERAPEUTIC APPROACHES TO THE CORRECTION OF COGNITIVE IMPAIRMENT IN PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES
Authors: Osovska Natalia Y. , Knyazkova Iryna I. , Kuzminova Natalia V. , Mazur Yulia V. , Shchepina Natalia V.
Published: January 2021

The aim: Was to improve the effectiveness of the treatment of cognitive impairment in patients with hypertension and type 2 diabetes.
Materials and methods: 56 patients (11 women and 45 men, average age 61.7 ± 4.3 years) with hypertension II, 2 degree and type 2 diabetes (average severity, subcompensation stage) were examined. 40 patients had moderate CI and 16 had mild CI. After the examination, the patients were divided into two groups and treated accordingly. The control group consisted of 20 healthy individuals.
Results: Vascular brain lesions that cause hypertension and diabetes very often lead to impaired cognitive function whose therapeutic correction has received little attention, especially in the pre-operative stages. 56 patients have been examined to study the efficacy and safety a combination of Phenibut and Ipidacrine as an additional therapy to standard basic treatment (antihypertensive and hypoglycemic) for the correction of cognitive dysfunction in patients with comorbidity of hypertension and type 2 diabetes mellitus.
Conclusions: One month after the beginning of the treatment, an improvement in psycho-emotional state and psychometric parameters was identified, which was manifested by an increase in concentration of attention, memory, psychomotor functions, speech activity together with normalization of blood pressure and metabolic parameters.
FEATURES OF CEREBROVASCULAR REACTIVITY IN PATIENTS OF YOUNG AGE WITH MIGRAINE
Authors: Kalashnikov Valeriy I. , Stoyanov Alexander N. , Pulyk Oleksandr R. , Bakumenko Iryna K. , Skorobrekha Viacheslav Z.
Published: January 2021

The aim of the study was to Doppler sonography study of cerebrovascular reactivity in young patients with migraine and comparison of autoregulation patterns between groups of migraine patients with aura and migraine without aura.
Materials and methods: We conducted the clinical Doppler examination of 124 young patients (18-45 years old), including 55 men and 69 women in the conditions of the clinical base of the Kharkiv Medical Academy of Postgraduate Education in 2017-2019. The criteria for involvement of patients in the study were: migraine without aura (group 1-63 patients), migraine with aura (group 2-61 patients) The control group consisted of 45 patients of the corresponding gender and age. The indicators of CVR were studied using the ultrasound device.
Results: A hyperreactive response to tests with CO2 and photoreactivity were more pronounced in the patients with migraine without aura. The patients with migraine with aura showed hyperreactivity in the test with O2, which was an indicator of the tendency to hyperconstriction. The hyperreactivity in the functional nitroglycerin test and the carotid compression test shows the state of the myogenic mechanism of changes in vascular tone. Insignificant hyperreactivity to orthostatic load detected in both groups shows the interest of the neurogenic regulatory link.
Conclusions: 1. The most important hemodynamic patterns in the patients with migraine are excessive perfusion with migraine without aura and difficult perfusion with migraine with aura. 2. For the patients with migraine without aura, a characteristic criterion for autoregulation is the pattern of hyperreactivity hypercapnic load and photostimulation. 3. The most important difference in the autoregulatory response in the patients with migraine with aura compared with migraine without aura is the hyperresponse to hyperventilation load, compression carotid and nitroglycerin tests.
MARKETING AUDIT OF UKRAINIAN PHARMACEUTICAL MARKET FOR LOCAL TREATMENT ACNE AND DEMODICOSIS
Authors: Koval Alina S. , Davtian Lena L. , Drozdova Anna A. , Naumova Liudmyla A.
Published: January 2021

The aim: To conduct a marketing audit of the pharmaceutical market of Ukraine for acne and demodicosis medications.
Materials and methods: The study used marketing methods of analysis, survey, observation methods and reference literature – State Register of Medicines of Ukraine of the State Expert Center of the Ministry of Health of Ukraine.
Results: As a result of marketing audit of retail audit data of pharmacy sales revealed that the leading sales in packaging is MNL benzylbenzoate, the share of which reached in different years from 45% to 32%, which was 1380902 and 647576 packages per year, respectively, in second place – metronidazole , benzoyl peroxide, zinc ointment and sulfur ointment respectively.
Conclusions: According to our analysis, it has been found that the highest sales volume (in packs) are of the low-cost brands, which are the most economically available and have the most effective therapeutic effect. Therefore, it is important to create multicomponent soft drugs in the form of cream and gel based on metronidazole, benzyl benzoate and benzoyl peroxide.
THE ROLE OF LIPOPROTEIN (A) AND PREGNANCY ASSOCIATED PLASMA PROTEIN A IN DIAGNOSTICS CORONARY HEART DISEASE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Sierkova Valentyna K. , Romanova Valentyna О. , Lilevska Anastasiia A. , Savytska Olena O.
Published: January 2021

The aim: To identify the significance of biomarkers characterizing the role of lipid disorders and the processes of destruction atherosclerotic plaque for the early diagnosis of CHD in patients with COPD.
Materials and methods: There were examined 153 patients, men aged 40-70 years, including 53 patients with COPD, 56 with a combination of COPD and CHD and 44 patients with stable CHD. The level of LP (a) and PAPP-A in the serum was determined by ELISA.
Results: There was increased level of LP (a) and PAPP-A in patients with CHD and with a combination of COPD and CHD. This increased level of LP (a) and PAPP-A was associated with the level of C-reactive protein. The mid level of LP (a) and PAPP-A in patients with COPD did not significantly differ from the reference values.
Conclusions: The increase level of lipoprotein (a) more than 18 mg/dl in patients with COPD may be regarded as a predictor of the development of CHD. The level PAPP-A more than 5 mIU/L in plasma of patients with COPD makes it possible to isolate the groups for CHD risk. The definition of LP (a) and PAPP-A in patients with COPD may contribute to the early diagnostics of coronary heart disease in the absence of its pronounced clinical manifestations.
PSYCHOCULTURAL TRAINING OF SENIOR PUPILS TO ADEQUELY PERCEIVE THE MEDIA SPACE CHALLENGES
Authors: Palamar Svitlana P. , Nazarenko Liudmyla A. , Vaskivska Halyna O. , Nezhyva Liudmyla L. , Korniienko Iryna A. , Zhelanova Viktorija V.
Published: January 2021

The aim: The research consists in the theoretical substantiation and experimental verification of the cultural and mental transformations of senior pupils under the influence of works of art, the media; highlighting the steps of forming the media literacy of pupils in the lessons of Ukrainian literature and in the after lessons in the process of independent activity of pupils to acquire their values and moral orientations.
Materials and methods: The complex of methods is used in the work: general scientific (analysis, synthesis, simile, comparison, systematization, generalization) and empirical
(observations, conversations, questionnaires).
Results: It is established, that media tools have manipulative character in the minds of teens, which is both destructive and constructive and also carry propaganda of deceptive spirituality ; education and science are the main tools to counteract speculative juggling of information. The necessity of formation of media literacy, media competence, their theoretical and methodological foundations for the protection of senior students from emotional manipulation is substantiated. The author’s vision of the definitions of “manipulation” of consciousness, “media education” is presented on the basis of research of scientific sources. Significant is the proposed steps to overcome stress as a result of emotional and cognitive transformations.
Conclusions: Educational activities of teachers, aimed at understanding of the media manipulation means by the pupils, the essential features of the art of words, will promote to preserve the health of pupils, serve the formation of their moral values, the formation of media literacy and media competence.
Tecnologías para la mejora de la transparencia
Authors: Ross Ibarra Marco Antonio
Published: January 2021

En este trabajo se analiza la transparencia, así como se observan las herramientas de las tecnologías de lainformación que han estado mejorando la eficiencia de la transparencia en múltiples campos. Debemos aclarar, que la transparencia no es algo nuevo, lo que, si es novedoso, es como se ha adaptado dentro de múltiples campos profesionales, usualmente pensamos en la transparencia como algo único del gobierno y su rendición de cuentas, pero la transparencia es algo mucho más adaptable. A través de este trabajo se mostrarán múltiples ejemplos de las tecnologías de la información que convierten a la transparencia en una herramienta para la mejora continua, para ofrecer sugerencias dentro de los múltiples ámbitos profesionales, demostrando los beneficios que han traído en otras áreas.
Investigating the importance of clinical topics for developing a curriculum on gastroenterology for pediatric residents
Authors: McNeil Kathleen , Rashid Mohsin
Published: January 2021

Background: Focused objectives provide effective learning. Pediatric residents in Canada follow objectives set by the Royal College of Physicians and Surgeons of Canada (RCPSC) with the goal of becoming competent general pediatricians. During the gastroenterology rotation, it remains unclear as to what clinical problems listed in the aforementioned objectives are crucial to understand as part of general pediatric practice. The purpose of this study was to identify the gastroenterological conditions of most importance to incorporate into a focused curriculum for pediatric residents.

Methods: All pediatricians across four Canadian Atlantic provinces were surveyed by a mailed questionnaire. Questions included demographics and ranking of the 14 clinical problems currently listed in the RCPSC objectives along with six more generated after input was gained from pediatric gastroenterologists.

Results: Of the 234 pediatricians surveyed, 132 (56%) responded, 48% of whom were general pediatricians. Celiac disease, gastroesophageal reflux, and obesity (currently not on the RCPSC list) were identified as important/very important conditions to understand by 94.4%, 96.1%, and 96.0% of respondents, respectively. There were no significant differences in rankings between general pediatricians and subspecialists. Most (75.6%) recommended  that a rotation in gastroenterology be mandatory during pediatric residency.

Conclusions: A survey of Canadian pediatricians provided an overview of the importance of different diseases to use in developing a  gastroenterology curriculum for core pediatric residency training. Such information is crucial as it can identify gaps in RCPSC learning objectives. Ongoing input from practicing general pediatricians can help keep medical schooling curricula updated.