bluuebunny/crossref_metadata_2025 huggingface dataset:
APLIKASI GOOGLE INTERNET SEBAGAI MEDIA PEMBELAJARAN ANAK SD DI DESA RAMBUTAN
Authors: Fatoni Fatoni , Putra M. Soekarno , Rasmila Rasmila , Lyanda Doli
Published: December 2023

Pendidikan yang terdapat pada desa rambutan dapat dikatakan telah maju akan tetapi pendidikan tentang teknologi komputer masih jauh belum berkembang terkhusus siswa maupun anak-anak desa rambutan yang masih buta terhadap teknologi komputer. Pemanfaatan teknologi komputer, yang salah satunya internet dapat dimaksimalkan untuk proses pembelajaran untuk meningkatkan kemampuan dalam membaca, berpikir kritis serta melakukan integrasi terhadap satu sumber bacaan dengan sumber bacaan lainnya. Kegiatan pengabdian ini memiliki tujuan dalam mengenalkan media aplikasi google untuk pembelajaran pada SDN 15 di desa rambutan secara pelatihan berkelompok. Aplikasi google dengan memanfaatkan internet dinilai menjadi salah satu media pembelajaran yang mudah untuk dipahami serta digunakan baik guru maupun siswa. Pelaksanaan pelatihan ini juga menerangkan bagaimana proses pemanfaatan aplikasi google. Adapun materi pada pelatihan ini yaitu pemanfaatan google search, youtube, gmail, google meet, google drive dan google form. Hasil pelatihan terhadap siswa SDN 15 yaitu siswa telah paham dasar dari penggunaan komputer serta mampu memanfaatkan aplikasi google dalam proses pembelajaran. Secara khusus, pelatihan ini memberikan suatu kemudahan untuk siswa dalam memahami materi saat proses pembelajaran berlangsung dengan memberikan sentuhan perubahan di sektor Pendidikan menuju arah yang lebih baik dan juga memberikan materi yang bernilai inovatif dan efektif.
WORKSHOP MANAJEMEN PEMBELAJARAN DIGITAL PENDIDIKAN MERDEKA BELAJAR BAGI GURU SMP NEGERI 32 KOTA PALEMBANG
Authors: Zubaidah R. A. , Susanto Yohanes
Published: December 2023

Di era Revolusi Industri 4.0 keinginan yang ingin dicapai dalam dalam metode pembelajaran yakni siswa atau mahasiswa yaitu penguasaan literasi baru. Literasi baru tersebut adalah Pertama, literasi data dan yang Kedua, literasi teknologi. Tujuan workshop ini adalah untuk mengkaji metode pembelajaran dalam pengembangan pendidikan. Merdeka Belajar Pendidikan merupakan jawaban atas kebutuhan sistem pendidikan di era Revolusi Industri 4.0. Selain itu, dalam sistem Pendidikan Merdeka Belajar masih mengutamakan pendidikan karakter di kota palembang Metode Workshop pengembangan pendidikan dengan 2 sesi yaitu pemaparan materi dan praktek penggunaan media digital. Metode yang digunakan Action Reaseach yang mementingkan beberapa proses tahapan : mulai dari persiapan, pelaksanaan hingga evaluasi kegiatan. Hasil: Workshop pembelajaran daring yang telah diselenggarakan oleh Tim Layanan Dosen STIE Trisna Negara dan Dosen Universitas Bina Insan memberikan pemahaman dan keterampilan baru kepada guru SMP Negeri 32 Kota Palembang dalam menggunakan berbagai platform digital yang dapat mendukung proses pembelajaran di masa pandemi Covid-19 . Kekurangan dari kegiatan ini adalah terbatasnya sarana dan prasarana yang dimiliki guru untuk mendukung pembelajaran berbasis digital, karena masih sedikitnya guru yang memiliki laptop atau komputer untuk mendukung pembelajaran. Kontribusi: dari kegiatan ini adalah mendukung sekolah untuk mendorong kemampuan tenaga pendidik dalam melaksanakan pembelajaran berbasis digital, khususnya di masa pandemi COVID-19.
PENINGKATAN PENGEMBANGAN UMKM BERKELANJUTAN DI ERA DIGITAL DAN GO GREEN PASCA PANDEMI COVID-19
Authors: Herlawati Herlawati , Andriansyah Bayu , Prasetya Ajie , Hartino Handry , Firdaus Ivan Nur , Shevani Juandika , Al Faiq Muhammad Zidan , Nurfaidzi Raihan
Published: December 2023

Pelaksanaan Pengabdian kepada Masyarakat (PkM) dalam bentuk Kuliah Kerja Nyata (KKN) oleh Mahasiswa serta Dosen dari Fakultas Ilmu Komputer Universitas Bhayangkara Jakarta Raya diadakan pada Perumahan Mustika Karangsatria RW 14 Tambun Utara Kabupaten Bekasi yang ditujukan untuk pelaku UMKM. Adapun tujuan dari pelaksanaan kegiatan ini yaitu agar pelaku UMKM yang termasuk pengurus pada RW 14 dapat: i) Memahami peranan penting digitalisasi terhadap data dari pelaku UMKM, dan ii) Memahami seberapa penting Go Green di lingkungan RW 14 setelah melewati pandemi Covid-19. Kegiatan KKN ini diharapkan dapat memberikan solusi permasalahan yang dialami oleh pelaku UMKM serta pengurus RW 14 yang termasuk ke dalam mitra kegiatan ini yaitu data pelaku UMKM di daerah tersebut belum tersusun dengan rapi, sehingga salah satunya dibuatlah sebuah aplikasi untuk menyimpan data tersebut berbasis website. Pada pelaksanaan kegiatan PKM ini, tim menerapkan pendekatan bidang edukasi (pendidikan) yang secara berkelanjutan. Metode pelaksanaan pada pelaksanaan kegiatan KKN ini yaitu a) Metode sosialisasi, b) Metode pengembangan, c) Metode penyuluhan serta d) Metode Pembelajaran. Hasil yang diperoleh dari pelaksanaan kegiatan ini berupa aplikasi yang dapat digunakan untuk proses pendataan pelaku UMKM untuk diolah serta memberikan bantuan kepada pengurus yang berada di sekitaran RW 14. Selain itu, itu diperoleh kondisi lingkungan yang hijau pada wilayah lapangan RW 14 pada sisi Go Green dengan melakukan penanaman kembali beberapa tanaman hijau
Suggestions for the Use of Big Data for a Manufacturing Company
Authors: Pavlov E. , Ryzhov A. , Balanev K. , Krepkov I.
Published: December 2023

This paper discusses the stages and methods of working with big data. It describes the tasks and problems in the field of logging and wood products production, solved by analyzing processed data. The article presents an algorithm for working with big data and its realization in the form of a program complex developed in the Python language. The main benefits derived from the visualization of processed information are listed.
Modelling of Phenol Biocatalytic Oxidation Tubular Reactor
Authors: Sidorov A. , Kosivtsov Yu. , Matveeva V. , Molchanov V. , Doluda V.
Published: December 2023

The oxidation of organic substrates to obtain popular products is an important part of modern chemistry and chemical technology. 1,4-benzoquinone is widely used for the preparation of dyes, pharmaceutical substances, and also as an intermediate product in basic chemical synthesis. Traditionally, 1,4-benzoquinone is synthesized by the oxidation of aniline with strong oxidizing agents, which is not very environmentally friendly and requires additional purification of the final product. The use of enzyme-containing catalysts can significantly improve the environmental performance of this process. As an enzyme, it is possible to use oxidoreductases of various structures, including peroxidases that catalyze the oxidation of organic substrates with hydrogen peroxide. Currently, a large number of works are devoted to the problem of enzymatic oxidation of organic substrates, but the issue of their use in large-volume reactors has not been considered in sufficient detail, and therefore modeling of such systems is an actuarial task of modern chemistry and chemical technology. The article presents the results of modeling a flow reactor for the oxidation of phenol with hydrogen peroxide to produce 1,4-benzoquinone. The simulation was carried out in the COMSOL Multiphysics 5.3 environment, taking into account the kinetic patterns of phenol oxidation, substance transfer processes, as well as thermal processes occurring inside the reactor. The possibility of achieving a yield of 1,4-benzoquinone of 94% with a reactor reaction zone length of 4 m has been shown; an increase in the diameter of the reaction zone from 0.05 to 0.15 m leads to a decrease in the yield of the target product to 50%, and an increase in the temperature of the heating wall from 30℃ to 40℃ leads to a 15% increase in yield. An increase in the initial concentration of phenol from 0.1 mol/L to 0.8 mol/L leads to a decrease in the yield of the reaction product 1,4-benzoquinone from 94% to 50%. This shows the need to add additional reaction zones if it is necessary to use concentrated solutions.
Patent Analysis of Atomic Emission Study of Sodium Content in Potash
Authors: Khafizov S. , Akhsanova O. , Sagdeeva G.
Published: December 2023

Potash is one of the most common and important chemical substances, widely used in various branches of the scientific and industrial sectors. During the production and receipt of potash, undesirable impurities are formed: alkaline (Na, K, Li), alkaline earth (Ca, Ba) elements, etc. It is proposed to identify such impurities using atomic emission spectroscopy. This article discusses atomic emission spectroscopy as a method based on the analysis of optical line emission spectra of atoms in the gas phase. This is one of the new and promising areas of qualitative and quantitative analysis. One type of atomic emission spectroscopy is flame photometry. This method is used to determine alkali (Na, K, Li), alkaline earth (Ca, Ba) and some other elements by atomic spectra or molecular bands. In order to study it, an analysis of patent activity was carried out up to 1960 on the website of the Patent Office of the Russian Federation. Based on the research data, a summary table was made and a graph was constructed for studying this method and obtaining potash, which shows an increase in interest on the part of researchers. A search of patents from 1960 to the present shows that interest in the study of atomic emission spectroscopy as a method of elemental analysis is growing, as well as interest in the chemical processes for producing potash. Conducted research proves that potash is a sought-after product due to its sustainable consumption and stable demand in the market.
Comparative Analysis of Plant Cover of Plain and Mountain Shirvan (Azerbaijan)
Authors: Gasimzade T.
Published: December 2023

A complete comparative analysis of the plain and mountainous parts of the Shirvan region of Azerbaijan has been shown in the paper. Basis the ecological and phytocenological principles widely used in modern geobotany have been taken in classifying the vegetation of the Shirvan territory. The species composition of edificators and subedificators (life forms) was taken as the main criterion when grouping and systematizing plants. Comparative analysis was carried out and for the first time, a map of the vegetation cover of Shirvan was compiled with botanical and geographical zoning on a scale of 1:100,000 based on ecological and phytocenological principles.
The Molecular Detection of the Anaplasma ovis Pathogens of the Serological Samples in Small Ruminants and Ixodid Ticks in Azerbaijan
Authors: Azizova A.
Published: December 2023

A total of 704 blood samples (561 sheep, 143 goats) were examined for the Anaplasma ovis infection during a 1-year period. PCR and ELISA were used for the detection of the A. ovis antibodies. PCR assay identified A. ovis in 20 (8.1%) sheep and 15 (6.09%) goats. Using ELISA assay, 8.53% (31) were positive (21 sheep, 10 goats). A total of 246 blood smears were examined for the presence of intra-erythrocytic inclusions using Giemsa stain. Among the collected specimens, 60 were found positive with an overall prevalence of 24.3%. Among the 60 positive animals, 26 (43.3%) were sheep and 34 (56.7%) were goat. In the peripheral blood samples, the other piroplasmids — Babesia ovis, Theileria ovis, Th. recondita — were followed in an associative form. The ticks were collected, and the species composition was appointed in order to determine the ticks parasitized and have a pathogenic lifestyle in small ruminants. The intensive infection with the ticks of 2 genera — Rhipicephalus and Hyalomma was followed in small ruminants. It was determined that 45.8% of sheep and 35.1% of goats were infected intensively with the ticks of the Hyalomma genus. 110 samples prepared from the ticks of the Hyalomma genus were tested from the PCR test according to the Anaplasma ovis pathogen. 45 samples (40.9%) were assessed positively that 21 samples of them belonged to sheep and 24 of them to goats. 80 samples prepared from the internal organs of the ticks were examined according to the A. ovis parasite and the obtained results were analyzed. In 5 out of 35 samples which detected the parasites, A. ovis was followed, and in 30 samples, the associative parasites: Th. ovis, B. ovis piroplasmids. The Rickettsia and Coxiella pathogens were also detected in the samples.
The Dynamics of the Prevalence of Diseases Among Women of Fertile Age in the Charyshsky District of the Altai Region, Living Near the Fall Areas of Separable Parts of Launch Vehicles
Authors: Kolyado I. , Plugin S.
Published: December 2023

Part of the territory of the Altai Region is involved in rocket and space activities as fall areas of separable parts of launch vehicles. This creates a number of specific problems for the ecological situation and the population living near the fall areas. Taking into account the aggravated demographic situation in Russia, this paper presents a dynamic analysis of the prevalence of diseases among women of fertile age in the Senteleksky village Council of the Charyshsky district, as a territory adjacent to the zone of rocket and space activities. The results of the medical examination of the population in 1999, 2006, 2011 and 2015 were used in the work. The most significant diseases and features of the dynamics of the prevalence of classes of diseases and individual nosologies were identified.
Experience of Using Temporary Balloon Occlusion of the Aorta for Delivery in Placenta Previa With Accreta (pl. percreta) (Clinical Observation)
Authors: Shostak D.
Published: December 2023

A clinical case is presented of a multiparous woman using temporary balloon occlusion of the aorta for delivery of placenta previa with accreta. The clinical picture and method of delivery are described in detail. Teamwork and the use of modern medical technologies made it possible to reduce intraoperative risks and preserve the patient’s quality of life.
Historical and Legal Aspects of Establishing the Boundaries of the Kyrgyz Republic
Authors: Sarbagysheva A.
Published: December 2023

Article focuses on the historical and legal aspects of the establishment of the borders of the Kyrgyz Republic. It examines the historical context and events that influenced the formation of the country’s borders, including territorial disputes, colonial heritage and post-Soviet development. Also analyzes the legal framework used to define and regulate borders, discusses international treaties, agreements and domestic legislation. Analyzing historical and legal aspects, this article gives an idea of the complex processes and factors affecting the establishment of the borders of the Kyrgyz Republic. The main purpose of the article is a comprehensive study of the historical and political aspects of the development of the problem of territorial integrity of states.
Legal Status of International Non-governmental Organizations in the Kyrgyz Republic
Authors: Tokhtakunova M.
Published: December 2023

Over the past decades, the relationship between the government and representatives of international non-governmental organizations has undergone dramatic changes. These changes are reflected in the bills for 2023 that are related to non-governmental commercial organizations. Taking into account the amendments to the law on NPOs, there is a strong need to analyze the legal status of INGOs in the Kyrgyz Republic. This article is an analysis of the status of NPOs over the past 10 years for the period from 2013 to 2023. Historical and comparative research methods were chosen as the methodology.
Analisis kemampuan pemecahan masalah ditinjau dari pikiran pseudo
Authors: Wulandari Hardiana Tri , Purnomo Eko Andy , Mawarsari Venissa Dian
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsikan kemampuan siswa memecahkan masalah. Kemampuan tersebut mencakup pemahaman mendalam yang melibatkan aspek konseptual dan potensi munculnya proses berpikir pseudo selama menyelesaikan masalah matematika. Penting bagi para pendidik untuk memahami kemampuan siswa dalam memecahkan masalah, dengan mempertimbangkan kemungkinan terjadinya proses berpikir pseudo selama proses pemecahan masalah. Berupa penelitian deskriptif kualitatif dengan subjek penelitian 30 siswa SMP kelas VII yang dianalisis lebih lanjut sebanyak 3 siswa, dikategorikan berdasarkan kemampuan matematisnya yaitu kemampuan tinggi, sedang dan rendah. Analisis data dilakukan dengan triangulasi data yaitu tes kemampuan, observasi dan wawancara. Tahapan dalam proses analisis dilakukan dengan reduksi, penyajian dan verifikasi data. Hasil penelitian menunjukkan bahwa siswa mengalami konteks pikiran pseudo dalam langkah pemecahan masalah yang berbeda, subjek KT mengalami pikiran pseudo dalam tahap merencanakan dan memeriksa, sementara KS pada tahap melaksanakan dan memeriksa, dan KR mengalami hal serupa pada seluruh langkah polya. Diharapkan untuk penelitian selanjutnya agar dapat melibatkan pengembangan strategi pembelajaran yang dapat mengurangi pikiran pseudo dalam proses berpikir siswa ketika memecahkan masalah matematika.
Pengaruh Kepemilikan Terhadap Nilai Perusahaan dengan Keputusan Investasi sebagai Moderasi pada Sektor Keuangan
Authors: Arsita Rinda Tri , Nurmawati Binar Arum
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh tidaknya kepemilikan manajerial, kepemilikan institusional terhadap nilai perusahaan dengan keputusan investasi sebagai moderasi pada emiten sektor asuransi dan lembaga pembiayaan di BEI tahun 2019-2021. Analisis data menggunakan metode SmartPLS. Hasil penelitian ini menunjukan bahwa kepemilikan manajerial tidak berpengaruh terhadap nilai perusahaan hal ini ditunjukan dengan nilai sebesar 0.945, artinya nilai signifikan lebih besar dari 0.05. kepemilikan institusional tidak berpengaruh terhadap nilai perusahaan hal ini ditunjukan dengan nilai sebesar 0.901, artinya nilai signifikan lebih besar dari 0.05.  Interaksi keputusan investasi pada hubungan kepemilikan manajerial tidak berpengaruh dengan nilai perusahaan hal ini ditunjukan dengan nilai sebesar 0.965, artinya nilai signifikan lebih besar dari 0.05.  Interaksi keputusan investasi pada hubungan kepemilikan institusional tidak berpengaruh dengan nilai perusahaan hal ini ditunjukan dengan nilai sebesar 0.956, artinya nilai signifikan lebih besar dari 0.05.
Pengaruh Net Interest Margin, Loan to Deposit Ratio, dan Non-Performing Loan Terhadap Return On Asset (Studi pada Perbankan yang Listing di BEI)
Authors: Prakoso Adi Bagus , Agustina Rachma
Published: December 2023

A healthy bank or not can be measured from the level of profit. If the bank has a profit every year, the bank is still able to maintain its viability. Bank profits can be measured from the Return on assets. This study aims to determine the effect of Net interest margin, Loan to deposit ratio and Non-performing loan on Return on assets in banking companies listed on the IDX in 2019-2021. The sample technique used in this study uses purposive sampling and the number of samples is 54 banking companies listed on the IDX in 2019-2021. The data analysis technique used is the classical assumption test (autocorrelation test), multiple linear regression test, and hypothesis testing. The results of this study indicate that the net interest margin has an effect on return on assets. Loan to deposit ratio has no effect on return on assets. Non-performing loans have no effect on return on assets.
Pengaruh Harga, Kualitas Produk, dan Promosi terhadap Minat Beli Kopi Kenangan pada Mall Ambassador, Jakarta Selatan
Authors: Pujiati Herni , Yosepha Sri Yanthy , Aditia Yudi
Published: December 2023

The purpose of the study was to determine whether price, product quality, and promotion affect the purchase intention of memorable coffee. This research used a quantitative method with a descriptive approach. The population is buyers of Kopi Kenangan Mall Ambassador with an average population of 200 people each day. The sampling technique uses a probability sampling method with a random sampling technique. Based on the Slovin formula with an error tolerance level of 5%, the number of samples used in this study was 135 respondents. The results showed that price has a significant effect on buying interest, product quality has a significant effect on buying interest, promotion has a significant effect on buying interest, also price, product quality, and promotion simultaneously have a significant effect on buying interest in Kopi Kenangan products at Ambassador Mall, South Jakarta.

Abstrak

Tujuan penelitian adalah untuk mengetahui apakah harga,kualitas produk dan promosi berpengaruh terhadap minat beli kopi kenangan. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan deskriptif. Populasi yang digunakan dalam penelitian ini adalah pembeli Kopi Kenangan Mall Ambassador dengan jumlah populasi rata – rata 200 orang perhari. Teknik pengambilan sampel menggunakan metode probability sampling dengan teknik random sampling.  Dari kisaran populasi sekitar 200 orang, berdasarkan rumus slovin dengan tingkat toleransi error 5% maka jumlah sampel yang digunakan dalam penelitian ini sebanyak 135 responden. Hasil penelitian menunjukan bahwa Harga berpengaruh signifikan terhadap Minat Beli,  Kualitas produk berpengaruh signifikan terhadap Minat Beli, Promosi berpengauh signifikan terhadap Minat Beli, serta ditemukan bahwa Harga, Kualitas Produk dan Promosi secara simultan berpengaruh signifikan terhadap Minat beli pada produk Kopi Kenangan di Mall Ambassador Jakarta Selatan.

Kata Kunci: Harga, Kualitas Produk, Promosi, Minat Beli
Pengaruh Program Cashback Xtra dan Gratis Ongkir Xtra terhadap Peningkatan Penjualan Toko “Tencomp” pada E-Commerce Shopee
Authors: Murniwati Murniwati , Yusnaldi Yusnaldi , Azzahra Fasa
Published: December 2023

This study aims to determine the effect of the Cashback Xtra  and Free Xtra  Delivery programs on increasing sales. This study uses Quantitative methods with 100 respondents with the criteria of "Tencomp" customers who have shopped using Xtra  cashback vouchers and free Xtra  shipping at E-Commerce Shopee. Cashback Xtra  has a positive effect on increasing sales with a significant value of 0.019 <0.050 with a t value of 2.380> 1.984. Free Shipping Xtra  has a positive effect on increasing sales obtained from a significant value of 0.002 <0.050 with a t value of 3.250> 1.984. The results of research on the F test with the influence of Cashback Xtra  and Free Shipping Xtra  affect the increase in sales with the results of the F test count> F table of 16.514> 3.087 with a significance level of 0.000. The magnitude of the influence of the independent variables on the increase in sales, namely by obtaining an R Square value of 0.254 or 25.4% means a positive effect. The result of this study is that there is a significant influence between Cashback Xtra  and Free Xtra  Shipping on increasing sales of the "Tencomp" store in shop e-commerce.

Abstrak

Penelitian ini bertujuan untuk mengetahui pengaruh program Cashback Xtra  dan Gratis Ongkir Xtra  Terhadap Peningkatan Penjualan. Penelitian ini menggunakan metode Kuantitatif dengan jumlah responden 100 orang dengan kriteria pelanggan “Tencomp” yang pernah berbelanja menggunakan voucher cashback Xtra  dan gratis ongkir Xtra  di E-Commerce Shopee. Cashback Xtra  berpengaruh secara positif terhadap peningkatan penjualan dengan nilai signifikan sebesar 0,019 < 0,050 dengan nilai t hitung 2,380 > 1,984. Gratis Ongkir Xtra  berpengaruh positif terhadap peningkatan penjualan diperoleh dari nilai signifikan 0,002 < 0,050 dengan nilai t hitung 3,250 > 1,984. Dan hasil penelitian pada uji F dengan pengaruh Cashback Xtra  dan Gratis Ongkir Xtra  berpengaruh terhadap peningkatan penjualan dengan hasil uji F hitung > F table sebesar 16,514 > 3,087 dengan tingkat signifikansi 0,000. Besarnya pengaruh variable bebas terhadap peningkatan penjualan, yaitu dengan diperoleh nilai R Square sebesar 0,254 atau 25,4% yang berarti berpengaruh secara positif. Hasil penelitian ini adalah terdapat pengaruh yang signifikan antara Cashback Xtra  dan Gratis Ongkir Xtra  terhadap peningkatan penjualan toko “Tencomp” di e-commerce shopee.

Kata Kunci: Cashback, Gratis Ongkir, Peningkatan Penjualan
Distribución mutación Braf según características epidemiológicas e histopatológicas en cáncer papilar de tiroides
Authors: Mendieta Álvarez Ximena Estefanía , Patiño Murillo Doménica Carolina , Bravo Muñoz Marx Ítalo
Published: December 2023

Introducción: El cáncer de tiroides se posiciona como una de las neoplasias más prevalentes en Ecuador, manifestándose típicamente en la cuarta década de vida, con una mayor incidencia en mujeres. El subtipo histológico predominante es el papilar (CPT), y diversos estudios han evidenciado que hasta un 80% de los casos de CPT presentan la mutación BRAF. Esta mutación se ha asociado con factores de pronóstico desfavorable, como la presencia de metástasis ganglionares, estadíos tumorales avanzados, extensión extratiroidea y características histológicas agresivas. Además, se ha observado una relación con una mayor tasa de recurrencia y una respuesta reducida al tratamiento con yodo. Ante este contexto, esta investigación se propone analizar la distribución de la mutación BRAF según características epidemiológicas e histopatológicas en pacientes con diagnóstico de cáncer papilar de tiroides en Ecuador.

Materiales y métodos: Este estudio se llevó a cabo de manera descriptiva y retrospectiva, abarcando a pacientes con diagnóstico de cáncer papilar de tiroides a quienes se les practicó el análisis genético para la detección de la mutación BRAF. La muestra incluyó 106 historias clínicas que cumplían con los criterios de selección establecidos

Resultados: La evaluación de las historias clínicas reveló la presencia de la mutación BRAF en el 75% de los casos. Este porcentaje fue más elevado en mujeres, individuos mayores de 45 años y residentes en áreas urbanas. Respecto a la ocupación, la mayoría de los pacientes se dedicaba a labores de limpieza y no presentaban antecedentes personales de exposición a radiación ionizante ni antecedentes oncológicos familiares. El 84% se encontraba en la etapa clínica I, y en su mayoría, la neoplasia estaba localizada en el lóbulo tiroideo derecho.

Conclusión: Este análisis subraya la imperiosa necesidad de identificar los factores de riesgo vinculados con la aparición del carcinoma papilar de tiroides en la población ecuatoriana. Los resultados indican una prevalencia significativa de la mutación BRAF, lo que subraya su relevancia como marcador pronóstico en esta enfermedad. Estos hallazgos pueden contribuir a una mejor comprensión de la epidemiología y la patogenia del cáncer de tiroides, así como a la mejora de las estrategias de prevención y tratamiento en el ámbito local.
Sustainability in High Reliability Organizations Employing Digitized Automation Inspection Processes
Authors: Koursaris Constantine
Published: December 2023

Digitization technologies offer several advantages over manual methods of accomplishing job-related tasks. Accurately measuring, documenting, and reporting surface damages, due to volume calculation variations are vital in increased efficiency, productivity, and thus mainly, human performance. Several sensation and perception issues were identified, mainly with concerns about accuracy of visual measurements that take place during quality control inspections. This research project portrays High Reliability Organizations utilizing digitized systems and automation concepts, with emphasis in Sensation, Perception, and Human Performance. Problem areas in measuring and assessing damaged Thermal Protection System (TPS) tile surfaces are identified and documented. Analysis of performance issues, causes, and effects, of human error factors are analyzed.
Сost-volume-profit analysis: practical aspects in e-commerce
Authors: Rozhkova Darya , Rozhkova Nadezhda , Serna Daniela , Blinova Uliana
Published: December 2023

As a result of the COVID-19 pandemic, e-commerce has experienced a significant increase. For Russian companies it's quite hard to compete with international organizations, mainly due to companies’ size and constant investments. The article addresses the issues that e-commerce companies face in terms of business models, costs, pricing and reaching a break-even point. We have studied the financial metrics of Ozon (leader company in Russian e-commerce market and have predicted net income for Ozon in 2023-2028. We outlined the limitations of break-even analysis in real-world scenarios for digital platforms.
Public debt from the viewpoint of national security and sovereignty
Authors: Tsvirko Svetlana
Published: December 2023

The paper examines public debt from the viewpoint of national security and sovereignty. The current situation with public debts in different types of countries is revealed. The risks, challenges and threats in the public debt sphere are presented. Different forms of public borrowings, such as loans from international organizations and banks, issuance of the securities on the domestic and international markets were analyzed. It was shown, that the international credits are characterized by the conditionality. In the case of borrowing on the open market using securities, the debtor depends on the current market conditions and can face significant deterioration of the situation. It was proved, that no form of borrowing is free from potential problems. The suggested classification of risks, challenges and threats can be useful for the efficiency of the public debt management.
RACIONALISMO CRÍTICO CONTRA O TOTALITARISMO
Authors: Baruk Andrêi
Published: December 2023

Resenha do livro:

RACIONALISMO CRÍTICO CONTRA O TOTALITARISMO
Crack influence and fatigue life assessment in rail profiles: a numerical study
Authors: Urassa Patrick , Habte Haileleoul Sahle , Mohammedseid Awel
Published: December 2023

Rail transportation is a pivotal mode of land transport for its efficiency in transporting passengers and freight across short or long distances; hence, the reliability and safety of rail systems are of key importance. Rolling contact fatigue (RCF), characterized by the cyclic loading of wheel-rail contacts, presents a significant challenge in the rail industry. This study presents a comprehensive numerical investigation on the influence of different crack orientations on the contact stress of the rail profile and subsequently the fatigue life. Using finite element analysis (FEA) with Abaqus and FE-safe software, the study examined different crack orientations’ impact on stress distribution and fatigue life of rail profiles. Employing the extended finite element method (XFEM), this study modeled cracks in rail profiles with different orientations: parallel, perpendicular, and oblique to the rail axis. finite element analysis was used to obtain stress distribution results, highlighting the impact of crack presence, and orientation on maximum contact stresses. Subsequently, fatigue analysis was performed using FE-safe software, wherein the FEA results were imported to estimate fatigue life and damage evolution. The study revealed that the presence of a crack significantly influences contact stress, fatigue life, and damage accumulation. The results further demonstrated that crack orientation has an impact on the severity of those effects. Oblique cracks exhibited higher impact compared to lateral and longitudinal cracks. The study provides valuable insights into rolling contact fatigue-related failures, aiding in better understanding and mitigation of such issues, thereby contributing to improved rail maintenance practices and system safety.
Discovering common pathogenetic processes between COVID-19 and tuberculosis by bioinformatics and system biology approach
Authors: Huang Tengda , He Jinyi , Zhou Xinyi , Pan Hongyuan , He Fang , Du Ao , Yu Bingxuan , Jiang Nan , Li Xiaoquan , Yuan Kefei , Wang Zhen
Published: December 2023

Introduction

The coronavirus disease 2019 (COVID-19) pandemic, stemming from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has persistently threatened the global health system. Meanwhile, tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) still continues to be endemic in various regions of the world. There is a certain degree of similarity between the clinical features of COVID-19 and TB, but the underlying common pathogenetic processes between COVID-19 and TB are not well understood.

Methods

To elucidate the common pathogenetic processes between COVID-19 and TB, we implemented bioinformatics and systematic research to obtain shared pathways and molecular biomarkers. Here, the RNA-seq datasets (GSE196822 and GSE126614) are used to extract shared differentially expressed genes (DEGs) of COVID-19 and TB. The common DEGs were used to identify common pathways, hub genes, transcriptional regulatory networks, and potential drugs.

Results

A total of 96 common DEGs were selected for subsequent analyses. Functional enrichment analyses showed that viral genome replication and immune-related pathways collectively contributed to the development and progression of TB and COVID-19. Based on the protein-protein interaction (PPI) network analysis, we identified 10 hub genes, including IFI44L, ISG15, MX1, IFI44, OASL, RSAD2, GBP1, OAS1, IFI6, and HERC5. Subsequently, the transcription factor (TF)–gene interaction and microRNA (miRNA)–gene coregulatory network identified 61 TFs and 29 miRNAs. Notably, we identified 10 potential drugs to treat TB and COVID-19, namely suloctidil, prenylamine, acetohexamide, terfenadine, prochlorperazine, 3′-azido-3′-deoxythymidine, chlorophyllin, etoposide, clioquinol, and propofol.

Conclusion

This research provides novel strategies and valuable references for the treatment of tuberculosis and COVID-19.
Comparing sputum microbiota characteristics between severe and critically ill influenza patients
Authors: Gu Zhixia , Zhang Yuanyuan , Zhao Xue , Liu Tingting , Sheng Shugui , Song Rui , Jin Ronghua
Published: December 2023

Background

Currently, limited attention has been directed toward utilizing clinical cohorts as a starting point to elucidate alterations in the lower respiratory tract (LRT) microbiota following influenza A virus (IAV) infection.

Objectives

Our objective was to undertake a comparative analysis of the diversity and composition of sputum microbiota in individuals afflicted by severe and critically ill influenza patients.

Methods

Sputum specimens were procured from patients diagnosed with IAV infection for the purpose of profiling the microbiota using 16S-rDNA sequencing. To ascertain taxonomic differences between the severe and critically ill influenza cohorts, we leveraged Linear Discriminant Analysis Effect Size (LEfSe). Additionally, Spearman correlation analysis was employed to illuminate associations between sputum microbiota and influenza Ct values alongside laboratory indicators.

Results

Our study encompassed a total cohort of 64 patients, comprising 48 within the severe group and 16 within the critically ill group. Intriguingly, Bacteroidetes exhibited significant depletion in the critically ill cohort (p=0.031). The sputum microbiomes of the severe influenza group were hallmarked by an overrepresentation of Neisseria, Porphyromonas, Actinobacillus, Alloprevotella, TM7x, and Clostridia_UCG-014, yielding ROC-plot AUC values of 0.71, 0.68, 0.60, 0.70, 0.70, and 0.68, respectively. Notably, Alloprevotella exhibited an inverse correlation with influenza Ct values. Moreover, C-reactive protein (CRP) manifested a positive correlation with Haemophilus and Porphyromonas.

Conclusion

The outcomes of this investigation lay the groundwork for future studies delving into the connection between the LRT microbiome and respiratory disorders. Further exploration is warranted to elucidate the intricate mechanisms underlying the interaction between IAV and Alloprevotella, particularly in disease progression.
Evaluating successes and challenges for effective governance of privately protected areas in Australia
Authors: Brugler Sarah
Published: December 2023

Australia has one of the world's largest privately protected area (PPA) estates and has been seen as a world leader in establishing PPAs, with significant growth since 2000. Despite the policy expectation that PPAs will continue to grow in Australia, there has been limited policy or academic consideration of the legal and governance arrangements that are best placed to enable this. This article uses adaptive governance as a conceptual framework for conducting doctrinal (to explore the legal rules) and socio-legal (to understand the implication and effects of the rules in practice) research to analyze the governance of conservation covenant regimes in Australia, with a particular focus on the State of Victoria. The article finds that Victoria’s conservation covenant regime has the legal foundations to enable adaptive governance and that conservation covenants are expected to continue to be important in maintaining and establishing new PPAs, with opportunities for covenants to similarly deliver ecosystem restoration and climate adaptation objectives. Ongoing adequate public investment in the regime and the ability of the regime to attract new landowners in important landscapes without better financial incentives are identified as key challenges. The analyses and findings, while focused on the Australian context, are expected to have applicability to other jurisdictions that are focused on implementing the Kunming-Montreal Global Biodiversity Framework and policies related to protected areas, private land conservation, ecosystem restoration, and climate adaptation.
Knowledge, attitude and practice toward oral anticoagulants among patients with atrial fibrillation
Authors: Li Chang , Meng Yubo , Meng Xiaoping , Song Yuming
Published: December 2023

Background

Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of stroke and other cardiovascular complications. Oral anticoagulants (OACs) are effective in reducing this risk. To investigate the knowledge, attitude and practice (KAP) toward OACs among patients with AF.

Methods

This web-based cross-sectional study was conducted at local Hospital between April 2023 and May 2023, and enrolled AF patients.

Results

A total of 491 valid questionnaires were collected, with 293 (59.67%) male and 73.93% resided in urban areas. The KAP scores were 4.64 ± 3.28, 21.09 ± 2.33 and 26.18 ± 2.15, respectively. Multivariate logistic regression analysis showed that junior high school [odd ratio (OR) = 0.346, 95% confidence interval (CI) = 0.145–0.825, P = 0.017], junior college/bachelor and above (OR = 6.545, 95% CI = 2.863–14.963, P < 0.001), monthly income ≥5,000 (OR = 2.343, 95% CI = 1.074–5.111, P = 0.032), never taken OACs (OR = 0.015, 95% CI = 0.004–0.059, P < 0.001), and having been diagnosed AF (6–10 months, OR = 4.003, 95% CI = 1.653–9.692, P = 0.002;over 20 months, OR = 4.046, 95% CI = 1.753–9.340, P = 0.001) were independently associated with knowledge. Knowledge (OR = 1.376, 95% CI = 1.162–1.629, P < 0.001), junior high school (OR = 0.258, 95% CI = 0.084–0.792, P = 0.018), monthly income ≥5,000 (OR = 5.486, 95% CI = 1.834–16.412, P = 0.002), and never undergone AF ablation (OR = 0.214, 95% CI = 0.097–0.471, P < 0.001) were independently associated with attitude. Knowledge (OR = 1.128, 95% CI = 1.030–1.235, P = 0.009), 70–79 years (OR = 2.193, 95% CI = 1.166–4.124, P = 0.015) and ≥80 years (OR = 4.375, 95% CI = 2.034–9.411, P < 0.001) were independently associated with proactive practice.

Conclusion

Patients with AF had inadequate knowledge, suboptimal attitude and inactive practice towards AF and OACs. Improving patient education, especially among those with lower education levels, enhances understanding and management of AF and OACs.
Investigation of fractured rock beneath a uranium-tailing storage dam through UAV digital photogrammetry and seismic refraction tomography
Authors: Guireli Netto Leonides , Singha Kamini , Moreira César Augusto , Gandolfo Otávio Coaracy Brasil , Albarelli Daniel Seabra Nogueira Alves
Published: December 2023

Failure events in dams can be associated with processes in the dam body and in the foundation of the structure. If they are properly identified in early stages, corrective actions can take place, leading to a reduction in the risk of collapse and/or rupture of the dam. Most studies on dams are carried out on the body of the dam; however, problems associated with the foundation of the structure can also lead to loss of stability and subsequent ruptures. This study presents an analysis of the advantages and limitations of the use of seismic refraction in hydrogeological studies of fractured aquifers under pressure from large loads, specifically a dam in this case. Seismic refraction data were collected on an outcrop of fractured rock near a uranium storage dam foundation in southeastern Brazil. The results and interpretations were supported by a structural analysis performed through manual strike measurements collected with a Clark compass and an uncrewed aerial vehicle digital photogrammetry survey in an outcrop. The digital photogrammetric survey mapped the spatial distribution and orientation of the geological structures of the rock mass. Although the structural measurements performed through digital photogrammetry presented greater variability than the measurements collected from the compass, the maximum density of the fracture measurements obtained from both methods were similar and were corroborated by the regional and local fracture patterning. The integration of seismic refraction data with geotechnical and geological investigations allowed us to identify the positioning of structural lineaments in the rock mass and zones with a higher degree of rock alteration. The identification of highly fractured zones in the rock mass from such non-invasive investigations could be used to assist in decision making for structural reinforcements in the foundation of the dam to avoid the loss of stability at the foot of the dam from possible leaks or water flows from the reservoir.
From gut to placenta: understanding how the maternal microbiome models life-long conditions
Authors: Ruiz-Triviño Jonathan , Álvarez Daniel , Cadavid J. Ángela P. , Alvarez Angela M.
Published: December 2023

The microbiome -defined as the microbiota (bacteria, archaea, lower and higher eukaryotes), their genomes, and the surrounding environmental conditions- has a well-described range of physiological functions. Thus, an imbalance of the microbiota composition -dysbiosis- has been associated with pregnancy complications or adverse fetal outcomes. Although there is controversy about the existence or absence of a microbiome in the placenta and fetus during healthy pregnancy, it is known that gut microbiota can produce bioactive metabolites that can enter the maternal circulation and may be actively or passively transferred through the placenta. Furthermore, the evidence suggests that such metabolites have some effect on the fetus. Since the microbiome can influence the epigenome, and modifications of the epigenome could be responsible for fetal programming, it can be experimentally supported that the maternal microbiome and its metabolites could be involved in fetal programming. The developmental origin of health and disease (DOHaD) approach looks to understand how exposure to environmental factors during periods of high plasticity in the early stages of life (e.g., gestational period) influences the program for disease risk in the progeny. Therefore, according to the DOHaD approach, the influence of maternal microbiota in disease development must be explored. Here, we described some of the diseases of adulthood that could be related to alterations in the maternal microbiota. In summary, this review aims to highlight the influence of maternal microbiota on both fetal development and postnatal life, suggesting that dysbiosis on this microbiota could be related to adulthood morbidity.
A stronger association of depression with rheumatoid arthritis in presence of obesity and hypertriglyceridemia
Authors: Shand Grayden , Fuller Daniel T. , Lufkin Leon , Lovelett Carly , Pal Nabendu , Mondal Sumona , Sur Shantanu
Published: December 2023

Background

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic and systemic inflammation. Recent research underscores the role of chronic inflammation in multiple common RA comorbidities such as depression, obesity, and cardiovascular diseases (CVDs), suggesting a potential overlap of the pathogenic mechanisms for RA. However, it is not well understood how the coexistence of these comorbid conditions impacts the risk of RA and whether any such association relates to body's inflammatory state.

Methods

We used data from the 2007-2010 United States National Health and Nutrition Examination Survey (NHANES) database and compared RA prevalence between subsamples with the presence of any two conditions among depression, obesity, and hypertriglyceridemia (HTG). Each subsample was further divided into three categories based on the serum level of the inflammatory marker C-reactive protein (CRP) and analyzed for statistically significant differences using three-way χ2 tests of independence.

Results

The study was conducted on 4,136 patients who fulfilled the inclusion criteria (representing 163,540,241 individuals after adjustment for sampling weights). Rates of depression, obesity, and HTG were found to be significantly higher (P < 0.001) among the subjects with RA compared with the control population with no arthritis. The presence of depression along with obesity or HTG showed a noticeably higher RA prevalence but such an association was not observed for the combination of obesity and HTG. The synergistic effect of HTG with depression was found to be most prominent at a medium CRP level (1–3 mg/L), while for obesity, the effect was observed across all CRP levels examined. These findings were further confirmed by the three-way χ2 test for independence.

Conclusions

The presence of obesity or HTG in subjects suffering from depression might pose an increased risk of RA. Inflammatory mechanisms potentially play an important underlying role as suggested by the strong dependency of the association to CRP level. Identification of synergistic associations between RA risk conditions could provide useful information to predict the development and progress of RA.