bluuebunny/crossref_metadata_2025 huggingface dataset:
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
Authors: Zhang Jin-Lan , Li Yu-Huan , Wang Lu-Lu , Liu Hong-Qi , Lu Shuai-Yao , Liu Yong , Li Ke , Liu Bin , Li Su-Yun , Shao Feng-Min , Wang Kun , Sheng Ning , Li Rui , Cui Jin-Jin , Sun Pei-Chun , Ma Chun-Xia , Zhu Bo , Wang Zhe , Wan Yuan-Hao , Yu Shi-Shan , Che Yongsheng , Wang Chao-Yang , Wang Chen , Zhang Qiangqian , Zhao Li-Min , Peng Xiao-Zhong , Cheng Zhenshun , Chang Jun-Biao , Jiang Jian-Dong
Published: December 2021

Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patients. FNC monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC50 between 1.2 and 4.3 μM, depending on viruses or cells, and selective index (SI) in 15–83 range. Oral administration of FNC in rats revealed a substantial thymus-homing feature, with FNC triphosphate (the active form) concentrated in the thymus and peripheral blood mononuclear cells (PBMC). Treating SARS-CoV-2 infected rhesus macaques with FNC (0.07 mg/kg, qd, orally) reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray. Single-cell sequencing suggested the promotion of thymus function by FNC. A randomized, single-arm clinical trial of FNC on compassionate use (n = 31) showed that oral FNC (5 mg, qd) cured all COVID-19 patients, with 100% viral ribonucleic acid negative conversion in 3.29 ± 2.22 days (range: 1–9 days) and 100% hospital discharge rate in 9.00 ± 4.93 days (range: 2–25 days). The side-effect of FNC is minor and transient dizziness and nausea in 16.12% (5/31) patients. Thus, FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus, followed by promoted immunity.
Virtual reality: a powerful technology to provide novel insight into treatment mechanisms of addiction
Authors: Mazza Massimiliano , Kammler-Sücker Kornelius , Leménager Tagrid , Kiefer Falk , Lenz Bernd
Published: December 2021

Due to its high ecological validity, virtual reality (VR) technology has emerged as a powerful tool for mental health research. Despite the wide use of VR simulations in research on mental illnesses, the study of addictive processes through the use of VR environments is still at its dawn. In a systematic literature search, we identified 38 reports of research projects using highly immersive head-mounted displays, goggles, or CAVE technologies to provide insight into treatment mechanisms of addictive behaviors. So far, VR research has mainly addressed the roles of craving, psychophysiology, affective states, cognition, and brain activity in addiction. The computer-generated VR environments offer very realistic, dynamic, interactive, and complex real-life simulations requesting active participation. They create a high sense of immersion in users by combining stereoscopic three-dimensional visual, auditory, olfactory, and tactile perceptions, tracking systems responding to user movements, and social interactions. VR is an emerging tool to study how proximal multi-sensorial cues, contextual environmental cues, as well as their interaction (complex cues) modulate addictive behaviors. VR allows for experimental designs under highly standardized, strictly controlled, predictable, and repeatable conditions. Moreover, VR simulations can be personalized. They are currently refined for psychotherapeutic interventions. Embodiment, eye-tracking, and neurobiological factors represent novel future directions. The progress of VR applications has bred auspicious ways to advance the understanding of treatment mechanisms underlying addictions, which researchers have only recently begun to exploit. VR methods promise to yield significant achievements to the addiction field. These are necessary to develop more efficacious and efficient preventive and therapeutic strategies.
Less entanglement exhibiting more nonlocality with noisy measurements
Authors: Zhu Gaoyan , Dilley Daniel , Wang Kunkun , Xiao Lei , Chitambar Eric , Xue Peng
Published: December 2021

The Clauser–Horne–Shimony–Holt (CHSH) inequality test is widely used as a mean of invalidating the local deterministic theories. Most attempts to experimentally test nonlocality have presumed unphysical idealizations that do not hold in real experiments, namely, noiseless measurements. We demonstrate an experimental violation of the CHSH inequality that is free of idealization and rules out local models with high confidence. We show that the CHSH inequality can always be violated for any nonzero noise parameter of the measurement. Intriguingly, less entanglement exhibits more nonlocality in the CHSH test with noisy measurements. Furthermore, we theoretically propose and experimentally demonstrate how the CHSH test with noisy measurements can be used to detect weak entanglement on two-qubit states. Our results offer a deeper insight into the relation between entanglement and nonlocality.
Adipose derived mesenchymal stem cell secretome formulation as a biotherapeutic to inhibit growth of drug resistant triple negative breast cancer
Authors: Nadesh Ragima , Menon Krishnakumar N. , Biswas Lalitha , Mony Ullas , Subramania Iyer K. , Vijayaraghavan Sundeep , Nambiar Ajit , Nair Shantikumar
Published: December 2021

In the present study, a protocol was developed for processing of human adipose derived mesenchymal stem cell secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro using breast cancer cell lines, and in vivo in a nude mice breast cancer model was studied to determine its role in suppressing triple negative breast cancer in a dose dependent manner. Because the secretome could have value as an add-on therapy along with a current drug, the effectiveness of the secretome both in monotherapy and in combination therapy along with paclitaxel was evaluated. The results showed significant cell kill when exposed to the secretome above 20 mg/ml at which concentration there was no toxicity to normal cells. 70 mg/ml of SF showed 90 ± 10% apoptosis and significant decrease in CD44+/CD24−, MDR1+ and PDL-1+ cancer cells. In vivo, the tumor showed no growth after daily intra tumor injections at 50 mg/ml and 100 mg/ml doses whereas substantial tumor growth occurred after saline intra tumor injection. The study concludes that SF is a potential biotherapeutic for breast cancer and could be used initially as an add-on therapy to other standard of care to provide improved efficacy without other adverse effects.
The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells
Authors: Khing Tin Myo , Choi Won Seok , Kim Dong Min , Po Wah Wah , Thein Wynn , Shin Chang Yell , Sohn Uy Dong
Published: December 2021

Paclitaxel is an anti-microtubule agent that has been shown to induce cell death in gastric cancer. However, the detailed mechanism of action is unclear. In this study, we reveal that the paclitaxel-induced cell death mechanism involves mitotic catastrophe, autophagy and apoptosis in AGS cells. Paclitaxel induced intrinsic apoptosis by activating caspase-3, caspase-9 and PARP. In addition, the significant increase in autophagy marker LC3B-II, together with Atg5, class III PI3K and Beclin-1, and the down-regulation of p62 following paclitaxel treatment verified that paclitaxel induced autophagy. Further experiments showed that paclitaxel caused mitotic catastrophe, cell cycle arrest of the accumulated multinucleated giant cells at the G2/M phase and induction of cell death in 24 h. Within 48 h, the arrested multinucleated cells escaped mitosis by decreasing cell division regulatory proteins and triggered cell death. Cells treated with paclitaxel for 48 h were grown in fresh medium for 24 h and checked for CDC2, CDC25C and lamin B1 protein expressions. These proteins had decreased significantly, indicating that the remaining cells became senescent. In conclusion, it is suggested that paclitaxel-induced mitotic catastrophe is an integral part of the cell death mechanism, in addition to apoptosis and autophagy, in AGS cells.
Understanding host-microbiota interactions in the commercial piglet around weaning
Authors: Saladrigas-García M. , D’Angelo M. , Ko H. L. , Nolis P. , Ramayo-Caldas Y. , Folch J. M. , Llonch P. , Solà-Oriol D. , Pérez J. F. , Martín-Orúe S. M.
Published: December 2021

Weaning is a critical period in the life of pigs with repercussions on their health and welfare and on the economy of the swine industry. This study aimed to assess the effect of the commercial early weaning on gut microbiota, intestinal gene expression and serum metabolomic response via an integrated-omic approach combining 16S rRNA gene sequencing, the OpenArray gene expression technology and 1H-NMR spectroscopy. Fourteen piglets from different litters were sampled for blood, jejunum tissue and caecal content two days before (− 2d), and three days after (+ 3d) weaning. A clearly differential ordination of caecal microbiota was observed. Higher abundances of Roseburia, Ruminococcus, Coprococcus, Dorea and Lachnospira genera in weaned piglets compared to prior to weaning showed the quick microbial changes of the piglets’ gut microbiota. Downregulation of OCLN, CLDN4, MUC2, MUC13, SLC15A1 and SLC13A1 genes, also evidenced the negative impact of weaning on gut barrier and digestive functions. Metabolomic approach pinpointed significant decreases in choline, LDL, triglycerides, fatty acids, alanine and isoleucine and increases in 3-hydroxybutyrate after weaning. Moreover, the correlation between microbiota and metabolome datasets revealed the existence of metabolic clusters interrelated to different bacterial clusters. Our results demonstrate the impact of weaning stress on the piglet and give insights regarding the associations between gut microbiota and the animal gene activity and metabolic response.
A free-geometry geodynamic modelling of surface gravity changes using Growth-dg software
Authors: Camacho Antonio G. , Vajda Peter , Miller Craig A. , Fernández José
Published: December 2021

Globally there is abundant terrestrial surface gravity data used to study the time variation of gravity related to subsurface mass and density changes in different geological, geodynamical and geotechnical environments. We present here a tool for analysing existing and newly acquired, 4D gravity data, which creates new findings from its reuse. Our method calculates in an almost automatic way the possible sources of density change responsible for the observed gravity variations. The specifics of the new methodology are: use of a low number of observation points, relatively small source structures, low signal/noise ratio in the data, and a free 3D source geometry without initial hypothesis. The process is based on the non-linear adjustment of structures defined by aggregation of small cells corresponding to a 3D section of the sub-floor volume. This methodology is implemented in a software tool, named GROWTH-dg, which can be freely downloaded for immediate use, together with a user manual and application examples.
Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas
Authors: Kido Takashi , Ishimoto Hiroshi , Ishii Hiroshi , Hara Kanako , Ozasa Mutsumi , Kawabata Hiroki , Kawanami Toshinori , Suzuki Yu , Yoshikawa Hiroki , Hara Atsuko , Sakamoto Noriho , Matsumoto Nobuhiro , Yoshii Chiharu , Fukuoka Junya , Fujita Masaki , Nakazato Masamitsu , Kadota Junichi , Mukae Hiroshi , Yatera Kazuhiro
Published: December 2021

Diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. We previously showed that pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma can be diagnosed by detecting MALT lymphoma translocation gene 1 (MALT1) translocations in bronchoalveolar lavage fluid (BALF) cells. Analysis of B-cell clonality based on immunoglobulin heavy chain (IGH) gene rearrangements was also reportedly useful for diagnosing pulmonary lymphoma. The aim of this prospective multicenter study was to evaluate the yet unknown diagnostic potential of combined detection of MALT1 translocations and clonality using BALF. We analyzed B- and T-cell clonality based on IGH and T-cell receptor (TCR) rearrangements together with MALT1 translocations using BALF of patients with clinically suspected pulmonary lymphomas. In total, 39 patients were evaluated and categorized into three groups: B-cell lymphoma, lymphoproliferative disorders, and other diseases. IGH rearrangement detection for B-cell lymphoma diagnosis exhibited sensitivity and specificity of 88.9% and 90.0%, respectively. TCR rearrangements were not observed in patients with B-cell lymphomas. The presence of IGH rearrangements together with the absence of TCR rearrangements indicated 96.0% specificity for the diagnosis of B-cell lymphoma. The sensitivity and specificity of MALT1 translocations for diagnosing MALT lymphoma were 28.6% and 100%, respectively. The combined detection of lymphocyte clonality and MALT1 translocations using BALF is suitable for screening and diagnosis of B-cell lymphomas. Analysis of specific genes such as MALT1 should improve the precision of B-cell lymphoma diagnosis.
A nomogram for predicting probability of low risk of MammaPrint results in women with clinically high-risk breast cancer
Authors: Lee Young Joo , Hwang Young Sol , Kim Junetae , Ahn Sei-Hyun , Son Byung Ho , Kim Hee Jeong , Ko Beom Seok , Kim Jisun , Chung Il Yong , Lee Jong Won , Lee Sae Byul
Published: December 2021

We aimed to develop a prediction MammaPrint (MMP) genomic risk assessment nomogram model for hormone-receptor positive (HR+) and human epidermal growth factor receptor-2 negative (HER2–) breast cancer and minimal axillary burden (N0-1) tumors using clinicopathological factors of patients who underwent an MMP test for decision making regarding adjuvant chemotherapy. A total of 409 T1-3 N0-1 M0 HR + and HER2– breast cancer patients whose MMP genomic risk results and clinicopathological factors were available from 2017 to 2020 were analyzed. With randomly selected 306 patients, we developed a nomogram for predicting a low-risk subgroup of MMP results and externally validated with remaining patients (n = 103). Multivariate analysis revealed that the age at diagnosis, progesterone receptor (PR) score, nuclear grade, and Ki-67 were significantly associated with MMP risk results. We developed an MMP low-risk predictive nomogram. With a cut off value at 5% and 95% probability of low-risk MMP, the nomogram accurately predicted the results with 100% positive predictive value (PPV) and negative predictive value respectively. When applied to cut-off value at 35%, the specificity and PPV was 95% and 86% respectively. The area under the receiver operating characteristic curve was 0.82 (95% confidence interval [CI] 0.77 to 0.87). When applied to the validation group, the nomogram was accurate with an area under the curve of 0.77 (95% CI 0.68 to 0.86). Our nomogram, which incorporates four traditional prognostic factors, i.e., age, PR, nuclear grade, and Ki-67, could predict the probability of obtaining a low MMP risk in a cohort of high clinical risk patients. This nomogram can aid the prompt selection of patients who does not need additional MMP testing.
Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan
Authors: Huang Chung-Feng , Kuo Hsing-Tao , Chang Te-Sheng , Lo Ching-Chu , Hung Chao-Hung , Huang Chien-Wei , Chong Lee-Won , Cheng Pin-Nan , Yeh Ming-Lun , Peng Cheng-Yuan , Cheng Chien-Yu , Huang Jee-Fu , Bair Ming-Jong , Lin Chih-Lang , Yang Chi-Chieh , Wang Szu-Jen , Hsieh Tsai-Yuan , Lee Tzong-Hsi , Lee Pei-Lun , Wu Wen-Chih , Lin Chih-Lin , Su Wei-Wen , Yang Sheng-Shun , Wang Chia-Chi , Hu Jui-Ting , Mo Lein-Ray , Chen Chun-Ting , Huang Yi-Hsiang , Chang Chun-Chao , Huang Chia-Sheng , Chen Guei-Ying , Kao Chien-Neng , Tai Chi-Ming , Liu Chun-Jen , Lee Mei-Hsuan , Tsai Pei-Chien , Dai Chia-Yen , Kao Jia-Horng , Lin Han-Chieh , Chuang Wang-Long , Chen Chi-Yi , Tseng Kuo-Chih , Yu Ming-Lung
Published: December 2021

The study evaluated the real-world treatment outcomes of Glecaprevir/pibrentasvir (GLE/PIB) including effectiveness, safety and healthcare resource utilization based on a nation-wide registry in Taiwan. The Taiwan HCV Registry (TACR) is a nation-wide platform organized and supervised by the Taiwan Association for the Study of the Liver. Data were analyzed for patients treated with GLE/PIB, including 3144 patients who had treatment outcome available. The primary endpoint was sustained virological response (SVR12, undetectable HCV RNA throughout 12 weeks of end-of-treatment). The overall SVR12 rate was 98.9% (3110/3144), with 98.8%, 99.4% and 100% in patients receiving 8 weeks, 12 weeks, and 16 weeks of GLE/PIB respectively. The SVR12 rate in the treatment-naïve cirrhotic patients receiving 8 weeks of GLE/PIB was 98.2% (108/110). The most common AEs were fatigue (7.5%), pruritus (6.7%) and dizziness (1.5%). The mean number of outpatient visits during the GLE/PIB was 5.94 visits for patients treated with 8 weeks, significantly different from the patients treated with 12 weeks of GLE/PIB (6.90 visits). The results support the effectiveness and safety of GLE/PIB treatment in real-world clinical practice, and provide further evidence that the shorter, 8-week GLE/PIB regimen is effective and cost-saving.
Diversification of ergot alkaloids and heritable fungal symbionts in morning glories
Authors: Beaulieu Wesley T. , Panaccione Daniel G. , Quach Quynh N. , Smoot Katy L. , Clay Keith
Published: December 2021

Heritable microorganisms play critical roles in life cycles of many macro-organisms but their prevalence and functional roles are unknown for most plants. Bioactive ergot alkaloids produced by heritablePeriglandulafungi occur in some morning glories (Convolvulaceae), similar to ergot alkaloids in grasses infected with related fungi. Ergot alkaloids have been of longstanding interest given their toxic effects, psychoactive properties, and medical applications. Here we show that ergot alkaloids are concentrated in four morning glory clades exhibiting differences in alkaloid profiles and are more prevalent in species with larger seeds than those with smaller seeds. Further, we found a phylogenetically-independent, positive correlation between seed mass and alkaloid concentrations in symbiotic species. Our findings suggest that heritable symbiosis has diversified among particular clades by vertical transmission through seeds combined with host speciation, and that ergot alkaloids are particularly beneficial to species with larger seeds. Our results are consistent with the defensive symbiosis hypothesis where bioactive ergot alkaloids fromPeriglandulasymbionts protect seeds and seedlings from natural enemies, and provide a framework for exploring microbial chemistry in other plant-microbe interactions.
Electromagnetic response in spiral magnets and emergent inductance
Authors: Kurebayashi Daichi , Nagaosa Naoto
Published: December 2021

Emergent electromagnetism in magnets originates from the strong coupling between conduction electron spins and those of noncollinear ordered moments and the consequent Berry phase. This offers possibilities to develop new functions of quantum transport and optical responses. The emergent inductance in spiral magnets is an example recently proposed and experimentally demonstrated, using the emergent electric field induced by alternating currents. However, the microscopic theory of this phenomenon is missing, which should reveal factors to determine the magnitude, sign, frequency dependence, and nonlinearity of the inductanceL. Here we theoretically study electromagnetic responses of spiral magnets by taking into account their collective modes. In sharp contrast to collinear spin-density wave, the system remains metallic even in one dimension, and the canonical conjugate relation of uniform magnetization and phason coordinate plays an essential role, determining the properties ofL. This result opens a way to design the emergent inductance of desired properties.
Rbec: a tool for analysis of amplicon sequencing data from synthetic microbial communities
Authors: Zhang Pengfan , Spaepen Stjin , Bai Yang , Hacquard Stephane , Garrido-Oter Ruben
Published: December 2021

Synthetic microbial communities (SynComs) constitute an emerging and powerful tool in biological, biomedical, and biotechnological research. Despite recent advances in algorithms for the analysis of culture-independent amplicon sequencing data from microbial communities, there is a lack of tools specifically designed for analyzing SynCom data, where reference sequences for each strain are available. Here we present Rbec, a tool designed for the analysis of SynCom data that accurately corrects PCR and sequencing errors in amplicon sequences and identifies intra-strain polymorphic variation. Extensive evaluation using mock bacterial and fungal communities show that our tool outperforms current methods for samples of varying complexity, diversity, and sequencing depth. Furthermore, Rbec also allows accurate detection of contaminants in SynCom experiments.
Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic
Authors: Di Domenico Laura , Sabbatini Chiara E. , Boëlle Pierre-Yves , Poletto Chiara , Crépey Pascal , Paireau Juliette , Cauchemez Simon , Beck François , Noel Harold , Lévy-Bruhl Daniel , Colizza Vittoria
Published: December 2021

Background

After one year of stop-and-go COVID-19 mitigation, in the spring of 2021 European countries still experienced sustained viral circulation due to the Alpha variant. As the prospect of entering a new pandemic phase through vaccination was drawing closer, a key challenge remained on how to balance the efficacy of long-lasting interventions and their impact on the quality of life.

Methods

Focusing on the third wave in France during spring 2021, we simulate intervention scenarios of varying intensity and duration, with potential waning of adherence over time, based on past mobility data and modeling estimates. We identify optimal strategies by balancing efficacy of interventions with a data-driven “distress” index, integrating intensity and duration of social distancing.

Results

We show that moderate interventions would require a much longer time to achieve the same result as high intensity lockdowns, with the additional risk of deteriorating control as adherence wanes. Shorter strict lockdowns are largely more effective than longer moderate lockdowns, for similar intermediate distress and infringement on individual freedom.

Conclusions

Our study shows that favoring milder interventions over more stringent short approaches on the basis of perceived acceptability could be detrimental in the long term, especially with waning adherence.
How do visible and UV light affect the structure and function of leaf-associated aquatic fungal communities polluted by TiO2 nanoparticles?
Authors: Du Jingjing , Qv Wenrui , Pu Gaozhong , Qv Mingxiang , Zhang Jin , Zhang Wenfang , Zhang Hongzhong
Published: December 2021

We assessed the phototoxicity of TiO2 nanoparticles on fungal structure and function. The fungal diversity was reduced by long-term exposure. However, the leaf decomposition rate was not inhibited rather than promoted under natural photoperiod.
Following the crystal growth of anthradithiophenes through atomistic molecular dynamics simulations and graph characterization
Authors: Ryno Sean M. , Noruzi Ramin , Karunasena Chamikara , Pokuri Balaji Sesha Sarath , Li Shi , Ganapathysubramanian Baskar , Risko Chad
Published: December 2021

An approach that combines atomistic molecular dynamics simulations and graph characterization is developed and deployed to follow the growth of organic crystals from the melt.
Unraveling the six stages of the current–time curve and the bilayer nanotubes obtained by one-step anodization of Zr
Authors: Li Pengze , Wang Heng , Ni Yilin , Song Ye , Sun Ming , Gong Tianle , Li Chengyuan , Zhu Xufei
Published: December 2021

This paper shed light on the growth mechanism of ZrO2 bilayer nanotubes and explain the six stages of the current–time curve in the anodization of Zr.
NHC-catalysed [3 + 2]-asymmetric annulation between pyrazolin-4,5-diones and enals: synthesis of novel spirocyclic pyrazolone γ-butyrolactones and computational study of mechanism and stereoselectivity
Authors: Gil-Ordóñez Marta , Maestro Alicia , Ortega Pablo , Jambrina Pablo G. , Andrés José M.
Published: December 2021

Herein we present the first asymmetric synthesis of spiropyrazolone γ-butyrolactones from 1H-pyrazol-4,5-diones and enals by an NHC-catalysed [3 + 2] annulation. DFT calculations carried out predict the experimental configuration of final adducts.
Glutaraldehyde cross-linked CDA/HBP-NH2nanofiber membrane for adsorption of heavy metal ions in wastewater
Authors: Chuanfeng Zang , Xiangye Han , Erying Dong , Feiyu Shen , Tingting Yan , Runyue Wang , GuangyuYu Zhang
Published: December 2021

A new type of nanofiber membrane was prepared by mixed electrospinning of cellulose diacetate and amino-terminated hyperbranched polymer (HBP-NH2), and glutaraldehyde (GA) crosslinking was used to improve its water resistance and shape retention.
UV electroluminescence emissions from high-quality ZnO/ZnMgO multiple quantum well active layer light-emitting diodes
Authors: Chen Shanshan , Zhan Tengrun , Pan Xinhua , He Haiping , Huang Jingyun , Lu Bin , Ye Zhizhen
Published: December 2021

ZnO/ZnMgO MQWs was employed as an active layer to fabricate p-GaN/MQWs/n-ZnO diode by molecular beam epitaxy. It showed sharp and efficient UV emission around 370 nm due to constraint of carriers in high-quality MQWs well layer.
Zein as a versatile biopolymer: different shapes for different biomedical applications
Authors: Tortorella Silvia , Maturi Mirko , Vetri Buratti Veronica , Vozzolo Giulia , Locatelli Erica , Sambri Letizia , Comes Franchini Mauro
Published: December 2021

Zein a versatile biomaterial in the biomedical field. Easy to chemically functionalize with good emulsification properties, can be employed in drug delivery, fabrication of bioactive membranes and 3D scaffolds for tissue regeneration.
Hybrid levan–Ag/AgCl nanoparticles produced by UV-irradiation: properties, antibacterial efficiency and application in bioactive poly(vinyl alcohol) films
Authors: Haddar Anissa , Ben Ayed Emna , Sila Assaad , Putaux Jean-Luc , Bougatef Ali , Boufi Sami
Published: December 2021

Hybrid Ag/AgCl nanoparticles with high antibacterial activity were synthesised using bacterial levan.
Effect of H-ZSM-5 zeolite content on the intrinsic kinetics of methanol dehydration to dimethyl ether over H-ZSM-5/Al2O3 molded catalyst
Authors: Zhokh Alexey , Trypolskyi Andrey , Gritsenko Valentina , Strizhak Peter
Published: December 2021

The catalyst composition affects the activation energy and methanol absorption heat, whereas the mechanism of methanol absorption (associative or dissociative) and pre-exponential factor exhibit no sensitivity to catalyst composition.
Chemical effects induced by gas–liquid jet flow
Authors: Zhang Zhiliang , Lu Jiaqi , Lv Bingqian , Liu Wei , Shen Shuyuan , Wang Dongting , Ji Jianbing
Published: December 2021

Gas–liquid jet flow is proved to be capable of inducing chemical effects which can lead to the decomposition of methylene blue.
Exfoliating spent cathode materials with robust interlayer interactions into atomic-thin nanosheets for boosting the oxygen evolution reaction
Authors: Huang Cheng , Lv Hong , Yang Zeheng , Lian Cheng , Du Jianglong , Liu Guoqiang , Tang Weijian , Xu Zhengjie , Chi Ziwei , Liu Honglai , Huang Haijian , Zhang Weixin
Published: December 2021

An efficient exfoliation strategy is developed to exfoliate spent electrode materials with robust interlayer interactions into atomically thin nanosheets for high performance in OER electrocatalysis.
Support-based modulation strategies in single-atom catalysts for electrochemical CO2 reduction: graphene and conjugated macrocyclic complexes
Authors: Fu Zhanzhao , Wu Mingliang , Zhou Yipeng , Lyu Zhiyang , Ouyang Yixin , Li Qiang , Wang Jinlan
Published: December 2021

An overview of two types of SACs for the CO2RR and the corresponding strategies to regulate the catalytic activity.
Organic rubrene/topological insulator Bi2Se3/SiO2 hybrid heterojunction photodetectors for broadband and ultrafast photodetection application
Authors: Wali Sartaj , Yin Qin , Li Jiao , Si Guoxiang , Shafi Muhammad , Ren Junfeng , Zhang Hongbin
Published: December 2021

Novel photodetectors have been developed by using the organic/inorganic hybrid heterostructure of the rubrene/topological insulator Bi2Se3, which demonstrate superior photodetection performance benefiting from the Dirac surface state at the heterointerface.
Quasi-three-dimensional self-doped conjugated polyelectrolytes based on a triphenylamine skeleton for non-fullerene organic solar cells
Authors: Zhou Dan , Zhang Hehui , Yang Fei , You Wen , Xu Zhentian , Xu Haitao , Tong Yongfen , Hu Bin , Hu Lin , Lv Ruizhi , Li Mingjun , Chen Lie
Published: December 2021

Two quasi-three-dimensional self-doped conjugated polyelectrolytes based on a triphenylamine skeleton are designed and employed as ETLs to modulate the cathode interface for efficient non-fullerene organic solar cells.
Ancrage territorial du modèle contractuel rizicole sénégalais : une perspective géographique et relationnelle
Authors: Touré Jean Marie Fodé , Chevalier Pascal , Bourgoin Jérémy
Published: December 2021

Pour relever les défis de l’agriculture africaine, notamment de l’autosuffisance alimentaire, de la création d’emploi et de richesse, le modèle du contrat agricole est promu par certains États et bailleurs de fonds internationaux dans le cadre d’un discours performatif sur les vertus des partenariats entre agro-industries et producteurs. Toutefois, les contrats agricoles suscitent des interprétations contradictoires. Les uns en font un modèle qui aurait des effets d’entraînement sur l’économie rurale, tandis que les autres y voient des stratégies de prédation des ressources agricoles, qui sont néfastes pour les communautés locales. D’un côté comme de l’autre, les analyses restent centrées sur des questions éthiques et parfois idéologiques. Les conditions de fonctionnement des contrats et leurs impacts en termes de développement sont peu abordés. Notre contribution, basée sur des enquêtes sociologiques menées au Sénégal, vise à caractériser objectivement les formes d’interaction (positive ou négative) entre contrats agricoles et développement des territoires qui abritent une filière rizicole. C’est à partir de ces enjeux de croisement entre développement agricole et développement territorial que nous développons une démarche méthodologique permettant de réaliser ce type de diagnostic. À l’échelle des régions dominées par la riziculture, nous mettons en exergue des trajectoires territoriales contrastées par rapport à l’interaction entre modèle agricole et développement territorial. Ce diagnostic est interprété par la connaissance des systèmes d’acteurs, notamment à l’aide de deux indicateurs, à savoir : la centralité, qui donne une indication sur les questions de gouvernance territoriale, et la densité des liens, qui renseigne sur l’importance du contrat agricole par rapport à d’autres modes de mise en relation. Concernant l’insertion des contrats agricoles, la structure des réseaux d’acteurs permet d’identifier un mode de gouvernance centralisé autour de la banque agricole nationale et de quelques industriels. Mais on note aussi une persistance des rapports informels et des structures communautaires (familles, amis, voisins) qui fonctionnent en parallèle du contrat agricole et qui remettent en cause le discours politique par rapport au potentiel transformateur des contrats agricoles.
Potential of Fermented Leek (Allium porrum L.) Cultured by Lactobacillus plantarum B1765 to Deliver Probiotics
Authors: Wikandari Prima Retno , Juniariani Renita Eka , Sujadmiko Wijo Kongko Kartika Yudha
Published: December 2021

The aim of this research is to study the probiotic properties of L.plantarum B1765 including the growth resistance at digestive tract pH, bile salts, antibiotics and invasion to pathogenic bacteria of Staphylococcus aureus and Escherichia coli in vitro. The potential of leek (Allium porrum L.) as a probiotic agent then were studied by inoculated the L.plantarum B1765 into pieces of leek and were fermented for 0, 6, 12, 18, 24 and 30 h at 37°C. The growth, pH and total acid then were identified. The results showed that L.plantarum B1765 had probiotic characteristics, namely resistance to gastrointestinal pH and bile salts with viability of more than 90%, showed a strong bactericidal against S. aureus and moderate to E. coli. In addition, L. plantarum B1765 can survive at 50 ppm of amoxicillin. The L.plantarum B1765 probiotic growth well in leek as indicated by its optimum growth reach to 1.17 x 108 CFU / mL for 6 hours of fermentation, an increase of 1 log cycle from the initial conditions of inoculation. A decrease in pH to 3.24 and an increase in TAT of 0.393%. L.plantarum B1765 is a potentially probiotics candidate and fermented leek could be an agent to deliver the L.plantarum B1765.
CO2 Capture using Sodium Silicate Solution in a Packed Bed Column
Authors: Muljani Srie , Setyawan Heru , Irianto Fryski Indra , Fransisco Sylvanus Pridia
Published: December 2021

The use of solid adsorbents such as amine-modified silica aerogels to capture CO2 has been commonly used but poses several obstacles, including expensive raw materials, production complexity, and considerations for adsorbent regeneration. This research develops sodium silicate solution as a carbon scrubber in a packed column. Besides being able to capture CO2, the amorphous silica which has economic value can also be produced. The packing size and CO2 flow rate were studied to prevent the deposition of silica inside of the packed column. The precipitated product analysis using XRF, XRD, FTIR, and SEM Image observed that CO2 was well absorbed by sodium silicate solution. The amorphous silica precipitated concentration reaches 98.6%.
Charcoal fuel from the mixture of coconut shell waste and coal: effect of carbonization temperature and the amount of coal mass in the mixture
Authors: Siswanto  , Nurma Wahyusi Kindriari , Panjaitan Renova
Published: December 2021

Contributing to the solution-finding for the availability of dwindling fossil energy, this study produced charcoal fuel from a biomass mixture of coconut shell waste and coal, using adhesive from meranti wood. The research was conducted by observing the effect of the carbonization temperature parameters and the amount of coal used in the mixture on the quality of charcoal fuel. The quality was evaluated on the calorific value, water content, and ash content. In addition, the data were analyzed mathematically using the response surface methodology to determine the interaction effect of independent variables on the response and to obtain the best conditions for producing charcoal fuel with the desired quality in the variable range of carbonization temperature of 300oC-500oC and coal mass in the range 10-30 grams. The results revealed that the temperature parameter had a significant effect on the calorific value, water content, and ash content. While the amount of coal mass did not significantly affect the calorific value and ash content but significantly affected the water content of charcoal fuel. The carbonization temperature and the amount of coal in the mixture of raw materials suggested were 409.625oCand10gr.
Enhancement of Computer Network Performance with VLAN
Authors: Ubaidillah Achmad , Joni Koko , Bachtiar Mohammad Iqbal , Kholida S. Ida
Published: December 2021

The computer network service provider must provide a good network service. Service quality is the most important factor and must always be maintained properly. The quality of service can change depending on the number and characteristics of service users. This study optimizes the performance of existing computer networks, namely ordinary LAN networks with the application of VLANs. It is very important because the number of network users is increasing and will continue to increase, while the need for good service quality is very urgent. The results showed that VLANs can improve computer network performance from the system existing, namely LAN network.
Information of Technology Service Governance Capability Level Audit on Khairun Ternate University (Case Study, System Information of Kubermas)
Authors: Dwi Surya Satria , Khairan Amal , Ahmad MS , Sirajuddin Hairil Kurniadi , Zainuddin
Published: December 2021

The Information system KUBERMAS (SIMAS) in an organization or information management plays an important role as an asset for the company, because it is very necessary for good and structured management of the information system. The purpose of this study was to see the results of the level of information technology capability at the LPPM Khairun Ternate University using the COBIT 5 framework in order to help universities in IT strategy and IT services. The results of the SIMAS audit at the capability level using the COBIT 5 framework were found at an average level of 2 managed processes. The result ability level or SIMAS ability level at LPPM Khairun University in the whole process of the MEA01 and BAI01 domain is at level 2 which is managed with a value process of 2.21 at this level the process has been implemented and managed appropriately and maintained. Management that has been set is controlled and executed.
Benefits and Risks of Cloud Computing in E-Government Tasks: A Systematic Review
Authors: Assaf Arief , IisHamsir Ayub Wahab , Muhammad Miftah
Published: December 2021

The utilities of Cloud Computing have an essential role in e-government affairs because they can reduce the cost of using information technology services and allow users to access services anytime and anywhere. The success factor of e-government requires leadership, significant funds and the ability to overcome the risks faced by governments. In several government agencies, such as Ministries or Local Governments in developing countries, cloud computing is still not widely adopted compared to other developed countries. In order to build cloud computing adoption, it is crucial to recognize that an essential and specific issue related to cloud computing is the potential and perceived security risks posed by the adoption of the technology. Cloud computing is an option that can provide e-government with lower infrastructure costs and less initial investment than traditional systems. Cloud computing in e-government offers excellent benefits, despite its many risks. Therefore, the main objective of this paper mainly focuses on analyzing the benefits and risks associated with cloud computing in e-government affairs. In this paper, researchers conducted a systematic review (SR) research method to identify the 12 benefits and 8 risks of cloud computing in e-government affairs. Then, these government organizations can benefit significantly from cloud computing.
Implementation Of K-Nearest Neighbor - Certainty Factor For Expert System Detection Of Idiopathic Thrombocytopenic Purpura
Authors: Puspaningrum Eva Y. , Nugroho Budi , Safira Dwi Putri
Published: December 2021

Idiopathic Thrombocytopenic Purpura (ITP) is an autoimmune disorder. ITP can occur in children and adults. This disease can be fatal because the platelet count is low due to the destruction of excessive platelets so that it can interfere with vital organs and bleeding occurs. The lack of knowledge of ordinary people about ITP disease, so many people assume that bruises and nosebleeds on the body are caused by fatigue. For that, we need a system that can imitate the expertise of an expert in diagnosing this disease based on the symptoms felt. The method used to support the expert system is the K-Nearest Neighbor and Certainty Factor methods which are a combination of 2 methods, where the classification results from the K-Nearest Neighbor method will be given a certainty value by the Certainty Factor method so as to produce a prediction. The results of combining the two methods can produce certainty in the diagnosis. Based on the test results using 3 test scenarios using parameter values k=3, k=5, k=7 and the results obtained the highest accuracy value with parameter value k=7 obtained an accuracy rate of 90,9%.
Design and Implementation of Travel Agent in the Face of the COVID-19 pandemic
Authors: Jauhari  , Doni A F , Ayu Mufarroha Fifin , Negara YDP
Published: December 2021

The tourism agent information system is an information system that brings together people who need tourism agents with tourism agent providers. This information system contains offers of tourism packages in several well-known tours that are often visited, this system is also available with request packages which will be directed to the admin to confirm with the desired request package. This system does not only contain offers about tour packages but also provides information and education about these tours, making it easier for users to choose the desired tour packages because they have received education or an overview of the tour. The development stages implemented include surveys, needs analysis, dedication, and implementation. Surveys and needs analysis serve as stages used in finding target users and their needs. User Interface Design is used to make user interaction as simple and efficient as possible, in terms of achieving user goals or what is often referred to as user-centered design. Conversion of the user interface design is done by choosing the right programming language on the web and generating an information system.
Automation system spraying desinfectant at Universitas Musamus
Authors: Zubaedah Reza , Loppies Stanly Hence Dolfi , Loudry Loudry
Published: December 2021

During the pandemic the learning process was conducted online and partly done face-to-face so that every day there are still students and employees who are in the campus environment. One of the prevention of covid transmission is done by spraying disinfectant when passing through the front gate of the campus. A design a prototype of an automatic disinfectant spray system and build a system on the prototype that can provide real time information related to monitoring the contents of the disinfectant tank by designing hardware. The results of the research built a disinfectant spraying automation system in front of the entrance gate of Universitas Musamus, to get results that prove that the system performance has been running as expected, there are several tests carried out such as tool testing and measuring the reading distance of the ultrasonic proximity sensor, and testing. sending SMS alert. How to provide information that the liquid in the tank has run out. Sensor sends a status signal for the disinfectant liquid level after spraying, a warning SMS is sent went the distance of disinfectant liquid and the ultrasonic sensor at a predetermined threshold.
Application of the Waterfall Method on a Web-Based Job Training Management Information System at Trunojoyo University Madura
Authors: Herawati Sri , Negara Yudha Dwi Putra , Febriansyah Husnul Fuadi , Fatah Doni Abdul
Published: December 2021

With the development of information technology, practical work at Trunojoyo University Madura needs improvement in applied management. Practical work is a mandatory activity for Information Systems undergraduate students which aims to test and apply theory as well as scientific proof of the courses that have been obtained. In the practical work management process is still done manually, it will take up a lot of time and frequent errors. Therefore, the Job Training Management Information System will be implemented using the waterfall model, the PHP programming language with Codeingniter as its framework. The waterfall model provides a sequential approach to software life phases starting from analysis, design, code implementation, testing, and maintenance. This research produces the results of the analysis of hardware and software requirements. The design produces Use case diagrams and Entity Diagrams. Testing produces a system by testing with black box testing with valid test results. This research produces a management system that is used to manage data related to practical work activities.
Development Of A Boarding House Search Information System Using The Waterfall Model
Authors: Dwi Putra Negara Yudha , Rizal Setiawan Dwi , Rochman Eka Mala Sari , Ayu Mufarroha Fifin
Published: December 2021

Internet technology can balance entrepreneurs in their efforts to develop their business ventures. Boarding house business. In Indonesia, especially in Madura, educational centers are mushrooming, especially private colleges and universities. This is followed by an increase in the number of houses or special buildings that offer boarding services for students who need them. The purpose of this research is to make a prototype application for finding and ordering boarding houses in Telang to make it easier for boarding house seekers to find information related to boarding houses that match what they want without having to go to the place one by one. As for the boarding house owners help recommend their boarding house. The stages in this study adopt the Waterfall system development method which consists of literature study, problem analysis, requirements modelling, business process modelling, system design and the results of each stage in building a boarding house search system. The results of this study indicate that the test is valid, that is, the compatibility test found minor issues on the IE, Firefox and Safari web browsers, but in this test sampled the opera, chrome and Firefox web browsers, this test is considered valid.
Decision Support Systems Suitability in Agarwood Tree Planting Using Simple Additive Weighting Method (Saw) In Merauke District
Authors: Xaverius Fransiskus , Zubaedah Reza , Resubun Yesenia
Published: December 2021

Gaharu is a blackish colored wood produced by a number of tree species from the genusAquilaria,especiallyAquilaria Malaccensis. This type is used in the fragrance industry (perfume and clover) because it has a fragrant aroma. Gaharu is a commodity of non-timber forest products (HHBK) which is quite reliable, especially when viewed from its very special price when compared to other NTFPs. A simple decision support system (DSS) can be defined as a computer-based system that is used to make it easier to make decisions. The decision-making ability used by the community is still conventional in determining suitable land for gaharu planting, without a model to assist the assessment process. Based on the results of research conducted using the Simple Additive Weighting (SAW) method with three samples of land and the type of gaharu to be planted isAquilaria Malaccensis, which refers to several indicators including soil type, soil pH, altitude, rainfall, and temperature. land C with a value of 0.42.