bluuebunny/crossref_metadata_2025 huggingface dataset:
Effective Elements for Workplace Responses to Critical Incidents and Suicide: A Rapid Review
Authors: Pearce Tania , Bugeja Lyndal , Wayland Sarah , Maple Myfanwy
Published: April 2021

Despite high rates of critical incidents (CIs) in working class occupations, there is a significant gap in our understanding of responses to these events. In this study, we aimed to inform a response training module by synthesising the key elements of pre-, during- and post-incident responses to CIs and suicide in the workplace. A rapid review identified studies on responses to CIs or suicide deaths in the workplace published between January 2015 and June 2020. A systematic search of six databases (Medline, CINAHL, PsycINFO, Sociology Collection, Academic Search and Business Search Complete) and grey literature was performed. Studies were excluded if the focus was on non-colleagues. Two reviewers independently conducted record screening, a review of the full text and assessed study quality. The existing evidence was synthesised and interventions were categorised using Haddon’s Matrix. Five studies were included, reporting on CIs across a range of workplace settings, including railways, factories, police and military, along with external critical response units. Overall, study quality was assessed as being poor. Most of the evidence focused on the pre-incident and post-incident stage. There is little evidence on responses to CIs in the workplace. Evidence-based education and training is necessary to establish organisational responses to assist with supporting workers exposed to workplace CIs.
Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea
Authors: Shin Jiyoung , Oh Jongmin , Kang In-Sook , Ha Eunhee , Pyun Wook-Bum
Published: April 2021

Background/Aim: Previous studies have suggested that the short-term ambient air pollution and temperature are associated with myocardial infarction. In this study, we aimed to conduct a time-series analysis to assess the impact of fine particulate matter (PM2.5) and temperature on acute myocardial infarction (AMI) among adults over 20 years of age in Korea by using the data from the Korean National Health Information Database (KNHID). Methods: The daily data of 192,567 AMI cases in Seoul were collected from the nationwide, population-based KNHID from 2005 to 2014. The monitoring data of ambient PM2.5 from the Seoul Research Institute of Public Health and Environment were also collected. A generalized additive model (GAM) that allowed for a quasi-Poisson distribution was used to analyze the effects of PM2.5 and temperature on the incidence of AMI. Results: The models with PM2.5 lag structures of lag 0 and 2-day averages of lag 0 and 1 (lag 01) showed significant associations with AMI (Relative risk [RR]: 1.011, CI: 1.003–1.020 for lag 0, RR: 1.010, CI: 1.000–1.020 for lag 01) after adjusting the covariates. Stratification analysis conducted in the cold season (October–April) and the warm season (May–September) showed a significant lag 0 effect for AMI cases in the cold season only. Conclusions: In conclusion, acute exposure to PM2.5 was significantly associated with AMI morbidity at lag 0 in Seoul, Korea. This increased risk was also observed at low temperatures.
Lifestyle Effects on the Risk of Transmission of COVID-19 in the United States: Evaluation of Market Segmentation Systems
Authors: Ozdenerol Esra , Seboly Jacob
Published: April 2021

The aim of this study was to associate lifestyle characteristics with COVID-19 infection and mortality rates at the U.S. county level and sequentially map the impact of COVID-19 on different lifestyle segments. We used analysis of variance (ANOVA) statistical testing to determine whether there is any correlation between COVID-19 infection and mortality rates and lifestyles. We used ESRI Tapestry LifeModes data that are collected at the U.S. household level through geodemographic segmentation typically used for marketing purposes to identify consumers’ lifestyles and preferences. According to the ANOVA analysis, a significant association between COVID-19 deaths and LifeModes emerged on 1 April 2020 and was sustained until 30 June 2020. Analysis of means (ANOM) was also performed to determine which LifeModes have incidence rates that are significantly above/below the overall mean incidence rate. We sequentially mapped and graphically illustrated when and where each LifeMode had above/below average risk for COVID-19 infection/death on specific dates. A strong northwest-to-south and northeast-to-south gradient of COVID-19 incidence was identified, facilitating an empirical classification of the United States into several epidemic subregions based on household lifestyle characteristics. Our approach correlating lifestyle characteristics to COVID-19 infection and mortality rate at the U.S. county level provided unique insights into where and when COVID-19 impacted different households. The results suggest that prevention and control policies can be implemented to those specific households exhibiting spatial and temporal pattern of high risk.
Does Environmental Regulation Improve the Green Total Factor Productivity of Chinese Cities? A Threshold Effect Analysis Based on the Economic Development Level
Authors: Li Xinfei , Xu Chang , Cheng Baodong , Duan Jingyang , Li Yueming
Published: April 2021

Improvement of green total factor productivity (GTFP) through environmental regulation is of great practical significance in promoting the high-quality development of urban economies. Based on panel data for 163 cities in China from 2003 to 2016, five indicators were selected to quantify the effects of environmental regulation: the SO2 removal rate, smoke and dust removal rate, solid waste utilization rate, domestic sewage treatment rate, and waste harmless treatment rate. This study evaluated the impact of environmental regulation on urban GTFP, and analyzed the threshold effect of urban economic development levels. The research results showed that the impact of environmental regulations on GTFP changed as the level of urban economic development increases. When the economic development level was low, environmental regulation had a significant positive effect on GTFP, especially the SO2 removal rate. When the economy developed to reach a medium level, the impact of environmental regulation on GTFP was negative. When the economic development level was high, the SO2 removal rate still had a significant positive impact on GTFP. The solid waste utilization rate had a significant negative impact on GTFP. It was concluded that the government should consider the local economic development level when formulating environmental regulation policies.
COVID-19 Medical Vulnerability Indicators: A Predictive, Local Data Model for Equity in Public Health Decision Making
Authors: Ong Paul M. , Pech Chhandara , Gutierrez Nataly Rios , Mays Vickie M.
Published: April 2021

This article reports the outcome of a project to develop and assess a predictive model of vulnerability indicators for COVID-19 infection in Los Angeles County. Multiple data sources were used to construct four indicators for zip code tabulation areas: (1) pre-existing health condition, (2) barriers to accessing health care, (3) built environment risk, and (4) the CDC’s social vulnerability. The assessment of the indicators finds that the most vulnerable neighborhoods are characterized by significant clustering of racial minorities. An overwhelming 73% of Blacks reside in the neighborhoods with the two highest levels of pre-existing health conditions. For the barriers to accessing health care indicator, 40% of Latinx reside in the highest vulnerability places. The built environment indicator finds that selected Asian ethnic groups (63%), Latinx (55%), and Blacks (53%) reside in the neighborhoods designated as high or the highest vulnerability. The social vulnerability indicator finds 42% of Blacks and Latinx and 38% of selected Asian ethnic group residing in neighborhoods of high vulnerability. The vulnerability indicators can be adopted nationally to respond to COVID-19. The metrics can be utilized in data-driven decision making of re-openings or resource distribution such as testing, vaccine distribution and other pandemic-related resources to ensure equity for the most vulnerable.
Frequency and Characteristics of Injuries and Rehabilitation Procedures in Rugby Players in Poland and France
Authors: Lipert Anna , Rasmus Paweł , Marczak Michał , Kozłowski Remigiusz , Jegier Anna , Timler Małgorzata , Timler Dariusz
Published: April 2021

Objectives: Rugby is sport with a high risk of injury. Repeated changes in exercise intensity and the high training intensity may cause to overuse injuries and long-term disability. The aim of the study was to analyze the prevalence of injuries during trainings and forms of rehabilitation procedures performed after their occurrence among elite and sub-elite rugby players. Methods: The data was obtained from 60 professional rugby males from France and Poland. Data were collected using paper-based recording form. It was a specially designed questionnaire which concerned specific details of the injury, including body location, type of injury, treatment and number of days off lost from playing rugby and on forms of rehabilitation procedures performed after their occurrence among elite and sub-elite rugby players. Results: During the study period, the overall incidence rate for injury suggested a 1.04 times more often injury occurrence (IRR = 1.04, 95% CI: 0.08; 2.00) among Polish players compared with French players; however, the distribution of injuries varied by country. The training injury incidence (TII) and incidence proportion (IP) were also higher in Poland than in France (p < 0.05) with the sprain as the most frequent type of injury in all rugby players. France was 7.8 times (IRR = 7.88, 95% CI: 1.29; 3.21) more likely to sustain a fracture than Poland, which much often experienced less serious injuries (bruise, rapture of muscle and ligament) (IRR = 3.02, 95% CI: 2.06; 3.98). Polish players were provided with various forms of physiotherapy while Franch players often worked with a physiotherapist with a therapeutic method (p < 0.005). Poland and France reported experiencing side effects after an injury and the most frequent was pain. In their opinions, the reasons influencing the effectiveness of rehabilitation are too quick return to the game and too short time of rehabilitation. Conclusions: The competitive level of the rugby player influences not only the frequency and type of injury occurrence, but also access to the different forms of rehabilitation. Nonetheless, the side effects occurring after injury and the causes of ineffective rehabilitation are still similar. Further studies are needed to gather significant data to accurately formulate future injury prevention protocols or recommend modifications to game laws or competition formats, aiming at players’ welfare.
Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve
Authors: Chen Szu-Han , Wu Chia-Ching , Lin Sheng-Che , Tseng Wan-Ling , Huang Tzu-Chieh , Yadav Anjali , Lu Fu-I , Liu Ya-Hsin , Lin Shau-Ping , Hsueh Yuan-Yu
Published: April 2021

Peripheral compressive neuropathy causes significant neuropathic pain, muscle weakness and prolong neuroinflammation. Surgical decompression remains the gold standard of treatment but the outcome is suboptimal with a high recurrence rate. From mechanical compression to chemical propagation of the local inflammatory signals, little is known about the distinct neuropathologic patterns and the genetic signatures after nerve decompression. In this study, controllable mechanical constriction forces over rat sciatic nerve induces irreversible sensorimotor dysfunction with sustained local neuroinflammation, even 4 weeks after nerve release. Significant gene upregulations are found in the dorsal root ganglia, regarding inflammatory, proapoptotic and neuropathic pain signals. Genetic profiling of neuroinflammation at the local injured nerve reveals persistent upregulation of multiple genes involving oxysterol metabolism, neuronal apoptosis, and proliferation after nerve release. Further validation of the independent roles of each signal pathway will contribute to molecular therapies for compressive neuropathy in the future.
The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
Authors: Adamcova Michaela , Kawano Ippei , Simko Fedor
Published: April 2021

Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets
Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship
Authors: Briu Lina-Marie , Maric Chrystelle , Cadoret Jean-Charles
Published: April 2021

The replication-timing program constitutes a key element of the organization and coordination of numerous nuclear processes in eukaryotes. This program is established at a crucial moment in the cell cycle and occurs simultaneously with the organization of the genome, thus indicating the vital significance of this process. With recent technological achievements of high-throughput approaches, a very strong link has been confirmed between replication timing, transcriptional activity, the epigenetic and mutational landscape, and the 3D organization of the genome. There is also a clear relationship between replication stress, replication timing, and genomic instability, but the extent to which they are mutually linked to each other is unclear. Recent evidence has shown that replication timing is affected in cancer cells, although the cause and consequence of this effect remain unknown. However, in-depth studies remain to be performed to characterize the molecular mechanisms of replication-timing regulation and clearly identify different cis- and trans-acting factors. The results of these studies will potentially facilitate the discovery of new therapeutic pathways, particularly for personalized medicine, or new biomarkers. This review focuses on the complex relationship between replication timing, replication stress, and genomic instability.
Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy
Authors: Subedi Lalita , Gaire Bhakta Prasad , Kim Sun-Yeou , Parveen Amna
Published: April 2021

Nitric oxide (NO) is a neurotransmitter that mediates the activation and inhibition of inflammatory cascades. Even though physiological NO is required for defense against various pathogens, excessive NO can trigger inflammatory signaling and cell death through reactive nitrogen species-induced oxidative stress. Excessive NO production by activated microglial cells is specifically associated with neuroinflammatory and neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, ischemia, hypoxia, multiple sclerosis, and other afflictions of the central nervous system (CNS). Therefore, controlling excessive NO production is a desirable therapeutic strategy for managing various neuroinflammatory disorders. Recently, phytochemicals have attracted considerable attention because of their potential to counteract excessive NO production in CNS disorders. Moreover, phytochemicals and nutraceuticals are typically safe and effective. In this review, we discuss the mechanisms of NO production and its involvement in various neurological disorders, and we revisit a number of recently identified phytochemicals which may act as NO inhibitors. This review may help identify novel potent anti-inflammatory agents that can downregulate NO, specifically during neuroinflammation and neurodegeneration.
Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models
Authors: Desamero Mark Joseph Maranan , Chung Soo-Hyun , Kakuta Shigeru
Published: April 2021

Understanding the host anti-fungal immunity induced by beta-glucan has been one of the most challenging conundrums in the field of biomedical research. During the last couple of decades, insights on the role of beta-glucan in fungal disease progression, susceptibility, and resistance have been greatly augmented through the utility of various beta-glucan cognate receptor-deficient mouse models. Analysis of dectin-1 knockout mice has clarified the downstream signaling pathways and adaptive effector responses triggered by beta-glucan in anti-fungal immunity. On the other hand, assessment of CR3-deficient mice has elucidated the compelling action of beta-glucans in neutrophil-mediated fungal clearance, and the investigation of EphA2-deficient mice has highlighted its novel involvement in host sensing and defense to oral mucosal fungal infection. Based on these accounts, this review focuses on the recent discoveries made by these gene-targeted mice in beta-glucan research with particular emphasis on the multifaceted aspects of fungal immunity.
Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease
Authors: Alabed Sedra , Zhou Heping , Sariyer Ilker K. , Chang Sulie L.
Published: April 2021

The deposition of amyloid-beta (Aβ) through the cleavage of amyloid-beta precursor protein (APP) is a biomarker of Alzheimer’s disease (AD). This study used QIAGEN Ingenuity Pathway Analysis (IPA) to conduct meta-analysis on the molecular mechanisms by which methamphetamine (METH) impacts AD through modulating the expression of APP. All the molecules affected by METH and APP were collected from the QIAGEN Knowledge Base (QKB); 78 overlapping molecules were identified. Upon simulation of METH exposure using the “Molecule Activity Predictor” feature, eight molecules were found to be affected by METH and exhibited activation relationships on APP expression at a confidence of p = 0.000453 (Z-score = 3.51, two-tailed). Core Analysis of these eight molecules identified High Mobility Group Box protein 1 (HMGB1) signaling pathway among the top 5 canonical pathways with most overlap with the 8-molecule dataset. Simulated METH exposure increased APP expression through HMGB1 at a confidence of p < 0.00001 (Z-score = 7.64, two-tailed). HMGB1 is a pathogenic hallmark in AD progression. It not only increases the production of inflammatory mediators, but also mediates the disruption of the blood-brain barrier. Our analyses suggest the involvement of HMGB1 signaling pathway in METH-induced modulation of APP as a potential casual factor of AD.
A Venom Allergen-Like Protein, RsVAP, the First Discovered Effector Protein of Radopholus similis That Inhibits Plant Defense and Facilitates Parasitism
Authors: Li Junyi , Xu Chunling , Yang Sihua , Chen Chun , Tang Shiqiao , Wang Jiafeng , Xie Hui
Published: April 2021

Radopholus similis is a migratory endoparasitic nematode that is extremely harmful to host plants. Venom allergen-like proteins (VAPs) are members of the cysteine-rich secretory protein family that are widely present in plants and animals. In this study, we cloned a VAP gene from R. similis, designated as RsVAP. RsVAP contains an open reading frame of 1089 bp encoding 362 amino acids. RsVAP is specifically expressed in the esophageal gland, and the expression levels of RsVAP are significantly higher in juveniles than in other life stages of R. similis. This expression pattern of RsVAP was consistent with the biological characteristics of juveniles of R. similis, which have the ability of infection and are the main infection stages of R. similis. The pathogenicity and reproduction rate of R. similis in tomato was significantly attenuated after RsVAP was silenced. In tobacco leaves transiently expressing RsVAP, the pathogen-associated molecular pattern-triggered immunity (PTI) induced by a bacterial flagellin fragment (flg22) was inhibited, while the cell death induced by two sets of immune elicitors (BAX and Gpa2/RBP-1) was repressed. The RsVAP-interacting, ras-related protein RABA1d (LeRabA1d) was identified in tomato hosts by yeast two-hybrid and co-immunoprecipitation assays. RsVAP may interact with LeRabA1d to affect the host defense response, which in turn facilitates nematode infection. This study provides the first evidence for the inhibition of plant defense response by a VAP from migratory plant-parasitic nematodes, and, for the first time, the target protein of R. similis in its host was identified.
One-Sided Chronic Intervillositis of Unknown Etiology in Dizygotic Twins: A Description of 3 Cases
Authors: van der Meeren Lotte E. , Krop Juliette , Dijkstra Kyra L. , Bloemenkamp Kitty W. M. , Cornish Emily F. , Nikkels Peter G. J. , van der Hoorn Marie-Louise P. , Bos Manon
Published: April 2021

Chronic intervillositis of unknown etiology (CIUE) is a rare, poorly understood, histopathological diagnosis of the placenta that is frequently accompanied by adverse pregnancy outcomes including miscarriage, fetal growth restriction, and intrauterine fetal death. CIUE is thought to have an immunologically driven pathophysiology and may be related to human leukocyte antigen mismatches between the mother and the fetus. Dizygotic twins with one-sided CIUE provide an interesting context to study the influence of immunogenetic differences in such cases. The main immune-cell subsets were investigated using immunohistochemistry. We identified three dizygotic twin pregnancies in which CIUE was present in only one of the two placentas. Two of the pregnancies ended in term delivery and one ended in preterm delivery. Presence of CIUE was correlated with lower placental weight and lower birthweight. Relative number of CD68, CD56, CD20, and CD3 positive cells were comparable between co-twins. The presence of one-sided CIUE in dizygotic twin pregnancy was associated with selective growth restriction in the affected twin. This suggests a unique fetal immunogenetic contribution to the pathogenesis of CIUE. Further study of dizygotic and monozygotic placentas affected by CIUE could identify new insights into its pathophysiology and into the field of reproductive immunology.
Micro- and Nanosized Substances Cause Different Autophagy-Related Responses
Authors: Wang Yung-Li , Zheng Cai-Mei , Lee Yu-Hsuan , Cheng Ya-Yun , Lin Yuh-Feng , Chiu Hui-Wen
Published: April 2021

With rapid industrialization, humans produce an increasing number of products. The composition of these products is usually decomposed. However, some substances are not easily broken down and gradually become environmental pollutants. In addition, these substances may cause bioaccumulation, since the substances can be fragmented into micro- and nanoparticles. These particles or their interactions with other toxic matter circulate in humans via the food chain or air. Whether these micro- and nanoparticles interfere with extracellular vesicles (EVs) due to their similar sizes is unclear. Micro- and nanoparticles (MSs and NSs) induce several cell responses and are engulfed by cells depending on their size, for example, particulate matter with a diameter ≤2.5 μm (PM2.5). Autophagy is a mechanism by which pathogens are destroyed in cells. Some artificial materials are not easily decomposed in organisms. How do these cells or tissues respond? In addition, autophagy operates through two pathways (increasing cell death or cell survival) in tumorigenesis. Many MSs and NSs have been found that induce autophagy in various cells and tissues. As a result, this review focuses on how these particles interfere with cells and tissues. Here, we review MSs, NSs, and PM2.5, which result in different autophagy-related responses in various tissues or cells.
Cobalt Regulates Activation of Camk2α in Neurons by Influencing Fructose 1,6-Bisphosphatase 2 Quaternary Structure and Subcellular Localization
Authors: Duda Przemysław , Budziak Bartosz , Rakus Dariusz
Published: April 2021

Fructose 1,6-bisphosphatase 2 (Fbp2) is a gluconeogenic enzyme and multifunctional protein modulating mitochondrial function and synaptic plasticity via protein-protein interactions. The ability of Fbp2 to bind to its cellular partners depends on a quaternary arrangement of the protein. NAD+ and AMP stabilize an inactive T-state of Fbp2 and thus, affect these interactions. However, more subtle structural changes evoked by the binding of catalytic cations may also change the affinity of Fbp2 to its cellular partners. In this report, we demonstrate that Fbp2 interacts with Co2+, a cation which in excessive concentrations, causes pathologies of the central nervous system and which has been shown to provoke the octal-like events in hippocampal slices. We describe for the first time the kinetics of Fbp2 in the presence of Co2+, and we provide a line of evidence that Co2+ blocks the AMP-induced transition of Fbp2 to the canonical T-state triggering instead of a new, non-canonical T-state. In such a state, Fbp2 is still partially active and may interact with its binding partners e.g., Ca2+/calmodulin-dependent protein kinase 2α (Camk2α). The Fbp2-Camk2α complex seems to be restricted to mitochondria membrane and it facilitates the Camk2α autoactivation and thus, synaptic plasticity.
Current and Prospective Methods for Assessing Anti-Tumor Immunity in Colorectal Cancer
Authors: Nussbaum Yulia I. , Manjunath Yariswamy , Suvilesh Kanve N. , Warren Wesley C. , Shyu Chi-Ren , Kaifi Jussuf T. , Ciorba Matthew A. , Mitchem Jonathan B.
Published: April 2021

Colorectal cancer (CRC) remains one of the deadliest malignancies worldwide despite recent progress in treatment strategies. Though immune checkpoint inhibition has proven effective for a number of other tumors, it offers benefits in only a small group of CRC patients with high microsatellite instability. In general, heterogenous cell groups in the tumor microenvironment are considered as the major barrier for unveiling the causes of low immune response. Therefore, deconvolution of cellular components in highly heterogeneous microenvironments is crucial for understanding the immune contexture of cancer. In this review, we assimilate current knowledge and recent studies examining anti-tumor immunity in CRC. We also discuss the utilization of novel immune contexture assessment methods that have not been used in CRC research to date.
Factors Affecting the Use of Smart Mobile Examination Platforms by Universities’ Postgraduate Students during the COVID-19 Pandemic: An Empirical Study
Authors: Alshurideh Muhammad Turki , Al Kurdi Barween , AlHamad Ahmad Qasim , Salloum Said A. , Alkurdi Shireen , Dehghan Ahlam , Abuhashesh Mohammad , Masa’deh Ra’ed
Published: April 2021

Recent years have seen an increasingly widespread use of online learning technologies. This has prompted universities to make huge investments in technology to augment their position in the face of extensive competition and to enhance their students’ learning experience and efficiency. Numerous studies have been carried out regarding the use of online and mobile phone learning platforms. However, there are very few studies focusing on how university students will accept and adopt smartphones as a new platform for taking examinations. Many reasons, but most recently and importantly the COVID-19 pandemic, have prompted educational institutions to move toward using both online and mobile learning techniques. This study is a pioneer in examining the intention to use mobile exam platforms and the prerequisites of such intention. The purpose of this study is to expand the Technology Acceptance Model (TAM) by including four additional constructs: namely, content quality, service quality, information quality, and system quality. A self-survey method was prepared and carried out to obtain the necessary basic data. In total, 566 students from universities in the United Arab Emirates took part in this survey. Smart PLS was used to test the study constructs and the structural model. Results showed that all study hypotheses are supported and confirmed the effect of the TAM extension factors within the UAE higher education setting. These outcomes suggest that the policymakers and education developers should consider mobile exam platforms as a new assessment platform and a possible technological solution, especially when considering the distance learning concept. It is good to bear in mind that this study is initial and designed to explore using smartphones as a new platform for student examinations. Furthermore, mixed-method research is needed to check the effectiveness and the suitability of using the examination platforms, especially for postgraduate higher educational levels.
Socioeconomic Benefits of the Shinkansen Network
Authors: Rungskunroch Panrawee , Jack Anson , Kaewunruen Sakdirat
Published: April 2021

High speed rail (HSR) networks have been an essential catalyst in stimulating and balancing regional economic growth that ultimately benefits the society as a whole. Previous studies have revealed that HSR services sustainably yield superior social values for people, especially for adults and those of working age. This has become an advantage of HSR networks over other forms of public transportation. The Shinkansen network in Japan is one of most successful HSR models. Its services bring significant social advantages to the communities it serves, such as shorter travel times and increased job opportunities. Nevertheless, the societal impact of HSR networks depends on many factors, and the benefits of HSR could also be overrated. The goal of this research is to measure the socioeconomic impacts of HSR on people of all genders and age groups. The outcomes could lead to more suitable development of HSR projects and policies. This study investigates data sets for Japanese social factors over 55 years in order to determine the impacts of HSR. The assessment model has been established using Python. It applies Pearson’s correlation (PCC) technique as its main methodology. This study broadly assesses social impacts on population dynamics, education, age dependency, job opportunities, and mortality rate using an unparalleled dataset spanning 55 years of social factors. The results exhibit that younger generations have the most benefits in terms of equal educational accessibility. However, the growth of the HSR network does not influence an increase in the employment rate or labour force numbers, resulting in little benefit to the workforce.
Spatial Distribution of Hunting Billbugs (Coleoptera: Curculionidae) in Sod Farms
Authors: Gireesh Midhula , Rijal Jhalendra P. , Joseph Shimat V.
Published: April 2021

The hunting billbug, Sphenophorus venatus vestitus Chittenden (Coleoptera: Curculionidae), is an important turfgrass pest, especially in sod farms. S. venatus vestitus larvae feed on the stems and roots of turfgrass. Damaged turfgrass is loosely held together and poses a challenge for machine harvesting. Additionally, the normal growth of turfgrass is affected, especially after winter dormancy. Because S. venatus vestitus larvae are hidden inside the stems or under the soil, larval management is challenging. To improve sampling and management, the spatial distribution patterns of S. venatus vestitus larvae and adults were assessed at four sod farm sites with a history of S. venatus vestitus infestation in central Georgia (USA). The larvae were sampled by soil cores using a hole cutter, whereas adults were collected using pitfall traps for 7 d. The spatial distributions of larvae and adults was analyzed using SADIE and variograms. The SADIE and variogram analyses revealed a significant aggregation pattern for adults, whereas aggregated distributions were detected for larvae with variogram analyses. The average ranges of spatial dependence for larval and adult samples were 3.9 m and 5.4 m, respectively. Interpolated distribution maps were created to visually depict S. venatus vestitus infestation hotspots within the sod farms.
Perceived Risk of Insect-Based Foods: An Assessment of the Entomophagy Attitude Questionnaire Predictive Validity
Authors: La Barbera Francesco , Amato Mario , Fasanelli Roberto , Verneau Fabio
Published: April 2021

Insects are a promising alternative protein source and their possible integration in the human diet has been extensively studied, also with reference to the degree of consumer acceptability and the main factors determining reluctance among Western consumers. Several studies have also proposed the use of protein meals derived from insects in animal feed as a possible way to promote the development of the insect chain. Consumer attitudes, perceived risks, and intention to eat insect-based foods have been extensively researched, yet the relationships between those factors are still unclear. On a sample of 202 Italian consumers, the present research used the Entomophagy Attitude Questionnaire (EAQ) to analyse the degree of acceptability of insects as food and meat obtained from animals raised on insect-based feeds with a specific focus on the role of attitudes and perceived risk. The research also evaluated the differences in acceptability between different types of animals fed with insects. The results show that the intention to engage in entomophagy is significantly correlated with all three of the EAQ’s subscales, as well as with perceived risk. However, the effect of perceived risk does not significantly improve the predictive validity of EAQ with respect to the intention to eat insect-based food. The results also show that the degree of acceptability for different insect meal-reared animals changes among consumers: beef and pork are characterized by a lower degree of acceptability, while poultry and fish are more accepted by consumers.
Bio-Insecticide of Thymus vulgaris and Ocimum basilicum Extract from Cell Suspensions and Their Inhibitory Effect against Serine, Cysteine, and Metalloproteinases of the Red Palm Weevil (Rhynchophorus ferrugineus)
Authors: Darrag Hossam Moustafa , Alhajhoj Mohammed Refdan , Khalil Hany Ezzat
Published: April 2021

The current study was designed to investigate the insecticide role of volatile constituents produced from cell suspensions of T. vulgaris and O. basilicum against R. ferrugineus. Constituents were extracted from cell suspension after 40 days. Growth kinetics were measured with an inoculation of Verticillium dahliae and identified by GC-MS. Total volatile phenolic constituents were measured. Insecticidal activity against R. ferrugineus (adult) and proteolytic enzyme activity in larvae were assessed. GC-MS showed that the T. vulgaris extract has higher amounts of thymol, p-cymene, γ-terpinene, β-caryophyllene, and linalool in comparison to the O. basilicum extract, which is rich in estragole, β-terpineol, (E)-β-ocimene, 1,8-cineole, germacrene D, and eugenol. The T. vulgaris extract showed an LC50 of 1032 µg/mL, followed by O. basilicum with an LC50 of 1246 µg/mL. The IC50 values against the total proteases were 110.8 and 119.4 µg/mL for T. vulgaris and O. basilicum, respectively. The IC50 for the trypsin-like serine proteinase assessment was 81.6 and 91 µg/mL for T. vulgaris and O. basilicum, respectively. Cysteine, chymotrypsin, and metalloproteinase assessment showed an IC50 above 5000 µg/mL for both extracts. The study is proposed as a potential approach to use T. vulgaris and O. basilicum extract as a bio-insecticide against R. ferrugineus using an accessible and efficient cell suspension technique.
A Greedy Scheduling Approach for Peripheral Mobile Intelligent Systems
Authors: Fadlallah Ghassan , Rebaine Djamal , Mcheick Hamid
Published: April 2021

Smart, pervasive devices have recently experienced accelerated technological development in the fields of hardware, software, and wireless connections. The promotion of various kinds of collaborative mobile computing requires an upgrade in network connectivity with wireless technologies, as well as enhanced peer-to-peer communication. Mobile computing also requires appropriate scheduling methods to speed up the implementation and processing of various computing applications by better managing network resources. Scheduling techniques are relevant to the modern architectural models that support the IoT paradigm, particularly smart collaborative mobile computing architectures at the network periphery. In this regard, load-balancing techniques have also become necessary to exploit all the available capabilities and thus the speed of implementation. However, since the problem of scheduling and load-balancing, which we addressed in this study, is known to be NP-hard, the heuristic approach is well justified. We thus designed and validated a greedy scheduling and load-balancing algorithm to improve the utilization of resources. We conducted a comparison study with the longest cloudlet fact processing (LCFP), shortest cloudlet fact processing (SCFP), and Min-Min heuristic algorithms. The choice of those three algorithms is based on the efficiency and simplicity of their mechanisms, as reported in the literature, for allocating tasks to devices. The simulation we conducted showed the superiority of our approach over those algorithms with respect to the overall completion time criterion.
Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
Authors: Bikov Andras , Frent Stefan M. , Meszaros Martina , Kunos Laszlo , Mathioudakis Alexander G. , Negru Alina Gabriela , Gaita Laura , Mihaicuta Stefan
Published: April 2021

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.
Astronomical Tide and Storm Surge Signals Observed in an Isolated Inland Maar Lake Near the Coast
Authors: Li Mingming , Li Chunyan , Xie Lingling , Huang Wei , Zheng Quanan , Tan Keyi , Hong Yingbin
Published: April 2021

Aimed at the explanation of clear tidal signal and storm surge signals in a closed inland lake near the coast (the Huguangyan Lake), this work uses a combined approach with observations and model experiments. Huguangyan Lake is a closed inland freshwater coneless volcanic crater lake near the coast in tropical southern China, less than 5 km from an estuary. It has a diameter of about 1.5 km and relatively deep water of up to 20 m. Bottom pressure was measured from an acoustic Doppler current profiler (ADCP) for 10 days in September 2018 and 10 days in January 2019. The observations encompass the period of Typhoon Mangkhut, which passed the region when it made its landfall. The time series demonstrate clear tidal and subtidal signals. The tidal signal remains even if we exclude the barometric pressure effect. Interestingly, the lake has no surface connection with the ocean. The astronomical tide has an amplitude of about 2 cm. The major tidal signals include the principal solar semidiurnal (S2) and lunisolar (K1) constituents. During the passage of Typhoon Mangkhut, the water level variability inside the lake increased by an order of magnitude (>0.3 m). To examine whether the lake water level change was due to the natural oscillations inside the lake (or seiche), a numerical wind-driven hydrodynamics model was designed using the 3-D Finite Volume Community Ocean Model (FVCOM). The results show that a small first-order seiche can be generated, but only with a time scale of minutes and with a magnitude much smaller than the observed surface elevation changes. This excludes any measurable seiche and the observed surface elevation change inside the lake cannot be wind-driven. Moreover, tides inside the lake are not generated by tidal potential, as the lake is too small for having a locally generated tide. The main result of our study has therefore excluded the local tidal-generating force, wind-driven seiche, and barometric effect, as possible causes of the lake oscillation which has tidal and subtidal signals. The subtidal variation is at least one order of magnitude greater than tides inside the lake and is caused by weather-induced overall coastal ocean water level oscillations transmitted into the lake through groundwater connection. All these lead to the major conclusion that the lake is connected to the coastal ocean through groundwater.
A Numerical Solution for Modelling Mooring Dynamics, Including Bending and Shearing Effects, Using a Geometrically Exact Beam Model
Authors: Martin Tobias , Bihs Hans
Published: April 2021

During the operation of moored, floating devices in the renewable energy sector, the tight coupling between the mooring system and floater motion results in snap load conditions. Before snap events occur, the mooring line is typically slack. Here, the mechanism of energy propagation changes from axial to bending dominant, and the correct modelling of the rotational deformation of the lines becomes important. In this paper, a new numerical solution for modelling the mooring dynamics that includes bending and shearing effects is proposed for this purpose. The approach is based on a geometrically exact beam model and quaternion representations for the rotational deformations. Further, the model is coupled to a two-phase numerical wave tank to simulate the motion of a moored, floating offshore wind platform in waves. A good agreement between the proposed numerical model and reference solutions was found. The influence of the bending stiffness on the motion of the structure was studied subsequently. We found that increased stiffness increased the amplitudes of the heave and surge motion, whereas the motion frequencies were less altered.
Falls Prevention and Quality of Life Improvement by Square Stepping Exercise in People with Parkinson’s Disease: Project Report
Authors: Mayoral-Moreno Asunción , Chimpén-López Carlos Alexis , Rodríguez-Santos Laura , Ramos-Fuentes María Isabel , Vaz-Leal Francisco José , Moral Manuel Alfredo , Pérez-Gómez Jorge , Adsuar José Carmelo
Published: April 2021

Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects physical, psychological, and social quality of life. Square Stepping Exercise (SSE) is an effective balance training program to prevent falls and to stimulate cognitive function in the elderly; however, no study has analyzed the effect of SSE in people with PD. The main objective is to investigate whether the application of SSE is safe, applicable, and can improve balance, and is effective in preventing falls, improving cognitive and psychological aspects and thus maximize quality of life in people with PD. Methods/Design: SSE will be performed three times per week for 8 weeks with an additional month follow-up after the intervention. Sixty people with PD will participate, randomly distributed into two groups: experimental group (SSE: n = 30) and control group (Usual care: n = 30). The primary measurements will be: (1) Applicability, (2) Safety, (3) Balance, and (4) Annual number of falls. Secondary measurements will be: (1) Sociodemographic information, (2) Physical condition, (3) Health-related quality of life, (4) Depressive symptoms, (5) Cognitive aspects, (6) Perceived functional social support, and (7) Anticipatory cognition.
The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, RB1 and ERBB2 Somatic Mutations
Authors: Kałużewski Tadeusz , Przybylski Grzegorz K. , Bednarek Michał , Glazar Sławomir , Grabiec Magdalena , Jędrzejczyk Adam , Kępczyński Łukasz , Kubiak Izabela , Kucharska Dorota , Morel Agnieszka , Owczarek Magdalena , Rożniecki Marek , Sałamunia Jordan , Szewczyk Dominika , Szwalski Jarosław , Kałużewski Bogdan
Published: April 2021

Bladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of non-invasive diagnostic tools. This short communication presents a case of a 68 year old male patient after an ineffective therapy, carried on for several years with symptoms commonly associated with prostate overgrowth that masked a carcinoma in situ of the urinary bladder. Implementation of several diagnostic techniques, including urine sediment cytology, immunocytochemistry, the fluorescence in situ hybridisation technique, the Bladder EpiCheck test and whole-genome sequencing, enabled the establishment of a correct diagnosis, implementation of appropriate treatment and provision of patient-friendly monitoring. The described case emphasises the usefulness of cell-based and liquid-based urine tests in bladder cancer diagnostic procedures.