bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic Social Defeat Stress Shifts Peripheral Circadian Clocks in Male Mice in a Tissue-Specific and Time-of-Day Dependent Fashion
Authors: Kong Xiangpan , Ota Simone M. , Suchecki Deborah , Lan Andy , Peereboom Anouk I. , Hut Roelof A. , Meerlo Peter
Published: January 2022

Uncontrollable stress is linked to the development of many diseases, some of which are associated with disrupted daily rhythms in physiology and behavior. While available data indicate that the master circadian pacemaker in the suprachiasmatic nucleus (SCN) is unaffected by stress, accumulating evidence suggest that circadian oscillators in peripheral tissues and organs can be shifted by a variety of stressors and stress hormones. In the present study, we examined effects of acute and chronic social defeat stress in mice and addressed the question of whether effects of uncontrollable stress on peripheral clocks are tissue specific and depend on time of day of stress exposure. We used mice that carry a luciferase reporter gene fused to the circadian clock gene Period2 (PER2::LUC) to examine daily rhythms of PER2 expression in various peripheral tissues. Mice were exposed to social defeat stress in the early (ZT13-14) or late (ZT21-22) dark phase, either once (acute stress) or repeatedly on 10 consecutive days (chronic stress). One hour after the last stressor, tissue samples from liver, lung, kidney, and white adipose tissue (WAT) were collected. Social defeat stress caused a phase delay of several hours in the rhythm of PER2 expression in lung and kidney, but this delay was stronger after chronic than after acute stress. Moreover, shifts only occurred after stress in the late dark phase, not in the early dark phase. PER2 rhythms in liver and WAT were not significantly shifted by social defeat, suggesting a different response of various peripheral clocks to stress. This study indicates that uncontrollable social defeat stress is capable of shifting peripheral clocks in a time of day dependent and tissue specific manner. These shifts in peripheral clocks were smaller or absent after a single stress exposure and may therefore be the consequence of a cumulative chronic stress effect.
Biomedical applications of tannic acid
Authors: Baldwin Andrew , Booth Brian W
Published: January 2022

Tannic Acid (TA) is a naturally occurring antioxidant polyphenol that has gained popularity over the past decade in the field of biomedical research for its unique biochemical properties. Tannic acid, typically extracted from oak tree galls, has been used in many important historical applications. TA is a key component in vegetable tanning of leather, iron gall ink, red wines, and as a traditional medicine to treat a variety of maladies. The basis of TA utility is derived from its many hydroxyl groups and its affinity for forming hydrogen bonds with proteins and other biomolecules. Today, the study of TA has led to the development of many new pharmaceutical and biomedical applications. TA has been shown to reduce inflammation as an antioxidant, act as an antibiotic in common pathogenic bacterium, and induce apoptosis in several cancer types. TA has also displayed antiviral and antifungal activity. At certain concentrations, TA can be used to treat gastrointestinal disorders such as hemorrhoids and diarrhea, severe burns, and protect against neurodegenerative diseases. TA has also been utilized in biomaterials research as a natural crosslinking agent to improve mechanical properties of natural and synthetic hydrogels and polymers, while also imparting anti-inflammatory, antibacterial, and anticancer activity to the materials. TA has also been used to develop thin film coatings and nanoparticles for drug delivery. In all, TA is fascinating molecule with a wide variety of potential uses in pharmaceuticals, biomaterials applications, and drug delivery strategies.
Differences Between Sexual and Nonsexual Homicides of Women in the United States: Findings From the National Violent Death Reporting System
Authors: De Veauuse Brown Natasha F. , Watson Ashley E. N.
Published: January 2022

Sexual homicide (SH) is the most severe outcome of sexual violence and disproportionately affects women. While SH is rare (<1% in the U.S.) and gravely understudied, it is among the most violent, feared, and well publicized forms of murder. Thus, examining predictors is pertinent to identifying targets for prevention and response efforts. Secondary analysis of 2015–2018 National Violent Death Reporting System data on 6461 female homicide victims age 20–64 was conducted to determine if SH represents a unique killing characterized by specific offender, victim, and incident profiles. Law enforcement and coroner/medical examiner narratives were reviewed to identify cases with sexual elements ( N=324). Logistic regression estimated odds ratios with 95% confidence intervals. Findings highlight important differences between SH and non-SH. SH victims were more likely to be single (AOR=1.7, p=.006), have a substance abuse problem (AOR=1.4, p=.04), or engaged in prostitution (AOR=10.4, p<.001). SH suspects were more likely to be male (AOR=2.5, p=.04), use an illicit substance in the preceding hours (AOR=1.6, p=.03), or had recent contact with police (AOR=1.6, p=.01). SH was more likely to occur in a hotel/motel (AOR=3.0, p=.002), by asphyxiation (AOR =13.38, p<.001), be perpetrated against an acquaintance (AOR=1.64, p=.007), or be precipitated by another serious crime (AOR=2.1, p<.001). Findings advance our understanding of SH victim, suspect, and incident profiles, which can help to better inform police/investigative practices and crime prevention strategies/interventions as well as to improve how SH cases are managed in correctional programs for offenders who have the opportunity for release back into society.
Districts Implementation of Active Shooter Drill Policies
Authors: Howard Cassandra C. , Kelchner Viki P. , Hilaire Breahannah , Campbell Laurie O. , Laguardia Eric D.
Published: January 2022

High-profile school shootings provoke public outcry and calls for policy responses to gun violence in schools. However, policy makers face pressure from diverse stakeholders with distinct agendas, and in some areas, there is little empirical research to guide policy makers’ decisions. Active shooter drills are one such example of a hotly debated policy response in need of further study. As a preliminary step to filling this research gap, this mixed-methods study investigated how school districts in Florida have implemented active shooter drills following legislation passed after the Marjory Stoneman Douglas High School shooting in Parkland, Florida. We analyzed school safety specialists’ perceptions and reports of drill procedures and their alignment with best practices. The majority of the districts surveyed aligned with Best Practices established by the National Association of School Psychologists and National Association of School Resource Officers. Implications for future research and considerations for the implementation of active shooter drills are discussed.
Acute Portal and Superior Mesenteric Vein Thrombosis with Topical Testosterone Therapy: An Adverse Drug Event Case Report
Authors: Adams Megan R. , Pijut Kyle D. , Uttal-Veroff Kelsey C. , Davis George A.
Published: January 2022

This is a case report of a 55-year-old Caucasian male prescribed topical testosterone therapy for 12 months prior to admission, when he was diagnosed with acute thrombosis in the portal vein (PVT) and superior mesenteric vein (SMV). The patient had a negative thrombophilia workup, including Factor V Leiden, Prothrombin G20210A, and JAK2 V617F mutations. There were no other pertinent laboratory markers that raised concern for the cause of thrombus. No strong familial history of venous thromboembolism (VTE) was reported during the patient’s initial workup. With this in mind, the patient’s use of topical testosterone therapy was considered the most likely risk factor for the PVT and SMV thrombus. During hospitalization, the patient was initiated on therapeutic anticoagulation with a heparin drip and discharged to home on apixaban for 3 months with extended therapy to be determined by outpatient hematologist. With no other identified VTE risk factors, probability that this patient’s VTE was attributed to testosterone was evaluated using the Naranjo scale with a calculated score of 6, which classifies the adverse reaction as “likely.” Clinicians should be aware of the possibility that topical testosterone therapy may be a risk factor for venous thrombosis in unusual sites.
Investigation on the microstructure and mechanical properties of Ti6Al4V titanium alloy electron beam welding joint
Authors: Zhao Xilong , Lu Xinhong , Wang Kun , He Feng
Published: January 2022

Electron beam welding (EBW) is a fusion joining process particularly suitable for welding titanium plates. In the present work, 2.5 mm thickness Ti6Al4V titanium alloy plates were butt-welded together with backing plates by EBW. The detailed procedures of experiments were used to investigate the microstructure and mechanical properties of welded joints. The optimum welding speed was determined by microstructure examinations, microhardness tests, X-Ray diffraction tests, shear punch tests (SPT) and stress simulation calculations. The results showed that all microstructure of welded metal (WM) was martensite phase under the different welding speeds. In the heat-affected zone (HAZ), the martensite phase gradually evolved to be small and equiaxed. It can be seen that the microstructure of each region in welded joints did not change significantly. When the welding speed is between 8 mm/s and 14 mm/s, it can be seen from the macroscopic appearance of the joints that there was no utterly fused penetration between the butt plate and substrate. Finite element simulation was carried out for the no-penetration depth under different welding conditions, and it was found that the stress suffered by the small no-penetration depth was the smallest. Using different welding parameters shows that the engineering stress in WM was higher than other areas, and BM was the lowest. As welding speed increases from 8 mm/s to 14 mm/s, the variation of microhardness distribution was not evident.
Fault diagnosis of rolling bearings based on improved direct fast iterative filtering and spectral amplitude modulation
Authors: Zhong Xianyou , Mei Quan , Gao Xiang , Huang Tianwei
Published: January 2022

As the transient impulse components in early fault signals are weak and easily buried by strong background noise, the fault features of rolling bearings are difficult to be extracted effectively. Focusing on this issue, a novel method based on improved direct fast iterative filtering and spectral amplitude modulation (IDFIF-SAM) is presented for detecting the early fault of rolling bearings. First, the ratio of the average crest factor of autocorrelation envelope spectrum to the average envelope entropy is taken as the fitness function to search the optimal parameters of direct fast iterative filtering (DFIF) adaptively via particle swarm optimization (PSO). Then, the efficient kurtosis entropy (EKE) index is being employed to choose the suitable components to reconstruct the signal. Finally, the reconstructed signal is subjected to spectral amplitude modulation (SAM) to strengthen the impulse features. The superiority of improved direct fast iterative filtering (IDFIF) over fixed-parameter DFIF, fast iterative filtering (FIF), and hard thresholding fast iterative filtering (HTFIF) is clarified through the simulated signal. Moreover, the comparative experimental analysis shows that the proposed IDFIF-SAM method can identify the early fault feature of rolling bearings more effectively.
Effects of interval friction coefficients on the differential mechanism dynamics
Authors: Lafi Wassim , Gharbi Fathi , Akrout Ali , Haddar Mohamed
Published: January 2022

The presence of a differential mechanism is fundamental in most automotive applications. Its importance stems from allowing a vehicle to take a curve. The differential should be well-lubricated to ensure its smooth operation and mitigate its vibration level. With lubrication conditions deteriorating over time, the sliding friction coefficient becomes difficult to predict its accurate value. Thus, scrutinizing the dynamic performance of the mechanism with deterministic sliding friction can be misleading. This paper aims to investigate the dynamic performance of the automotive differential with the presence of interval sliding friction. To this end, a 3D dimensional model of automotive differential with time-varying mesh stiffness (TVMS) and bearing flexibility is proposed. The influence of sliding friction on TVMS for straight bevel gear is revealed. The Newton-Euler formulation is used to derive the dynamic equations governing the motions of the automotive differential with friction. The Chebyshev inclusion function and the least square method are used to deal with the interval mathematical formulation of the model. The scanning method is used as a reference method in this paper. There are quite similarities between the results derived by the scanning method and that of the interval process method. The reliability analysis of the differential is conducted. The outcome of this research shows that any variation of the sliding friction can alter the dynamic performance of the differential significantly. The differential is more sensitive to the friction coefficient between the ring gear and the drive pinion and between the left-side gear and two planets. The findings should make an important contribution to the analysis of the differential mechanism.
Impacts of Joule heating and viscous dissipation on MHD pulsatile flow of third grade nanofluid in a channel
Authors: Govindarajulu K , Subramanyam Reddy A
Published: January 2022

The current exploration deals with the third grade hydromagnetic pulsating flow of blood-gold nanofluid in a channel with the presence of Ohmic heating, viscous dissipation and radiative heat. In the present analysis, blood (base fluid) is considered as third-grade fluid and gold (Au) as nanoparticle. This investigation is useful in the fields of food processing system, pressure surges (pulsatile flow application), biomedical engineering, nano drug delivery, radiotherapy, and cancer therapeutic (nanofluid application). Perturbation method is employed to transform the set of governing partial differential equations (PDEs) into the ordinary differential equations (ODEs) and then solved by employing the fourth order Runge-Kutta method with the aid of the shooting technique. The impacts of emerging dimensionless parameters of velocity, temperature, and heat transfer rate of blood-Au nanofluid are analysed via pictorial outcomes in detail. The obtained results depict that the improvement in viscous dissipation and heat source enhanced the temperature of third grade nanofluid. The velocity and temperature of the nanofluid are declining functions with the enhancement of frequency parameter, material parameter, and non-Newtonian parameter respectively. Intensifying the volume fraction of nanoparticle dwindles the velocity and temperature of nanofluid. Enhancing volume fraction and viscous dissipation accelerates the heat transfer rate of nanofluid. The velocity, temperature, and heat transfer rates are decreased by an escalation of the Hartmann number. Further, enhancing the radiation parameter reduces the heat transfer rate and temperature of nanofluid.
Influence of Fly Ash and Emery based particulate reinforced AA7075 surface composite processed through friction stir processing
Authors: Suganeswaran K. , Parameshwaran R. , Sathiskumar R. , Ram Prabhu T. , Nithyavathy N.
Published: January 2022

The novel friction stir technology is adopted in modern automotive industries to meet the desired properties like hardness, impact toughness and tribological behaviour over the conventional techniques like stir casting, compo casting, squeeze casting, electroplating and infiltration methods. AA7075 surface composites fabricated with different volume fractions of fly ash and emery particles is said to enhance the aforementioned properties. The composites are processed through friction stir process (rotational speed −1200 rpm, transverse speed – 56 mm/min, tool tilt angle – 2 °). During characterization, the Microstructural examination of surface composites depicts fine and homogenous distribution of reinforcements in the friction stir process region owing to severe plastic deformation and dynamic recrystallization process. Substantially, good interface is formed between the reinforcement particulates and base substrate. Inclusion of Fe3O4, Al2O3 and SiO2 constituents through fly ash and emery reinforcements associated with the homogenous dispersion strengthening mechanism favours for the superior hardness of surface hybrid composite specimen 50E50FA. Decremented grain size and load bearing capacity of the reinforcements is beneficial for the crack propagation resistance that enhances the impact toughness behaviour (17.4 J/cm2) of the same specimen. Wear rate of the specimens are evaluated through pin on disc tribometer. The decrease in the wear rate of hard specimen 50E50FA is observed due to the reduced contact area between its surface and counter disc. The morphology of worn specimens using SEM analysis shows the combined abrasive and adhesive wear as the worn mechanism.
Part dynamics in the intermediate regime of a linear vibratory feeder
Authors: Boopathi Balaji , Gupta Burela Ramesh , Ponniah Ganeshthangaraj
Published: January 2022

Linear vibratory feeder is one of the most extensively used part feeding systems in a production line. The part motion on the feeder can be sliding or hopping or a combination of these two. Based on the dynamics of part motion this paper identifies three distinct regimes. A mathematical model was developed that can predict the trend in conveying velocity in these regimes. This model can provide the parts position as a function of time and has considered relative displacement between the part and the conveying surface. The simulation was validated by performing experiments for a range of vibration frequencies and amplitudes.
Branding in libraries: Identifying key requirements and dimensions to provide a conceptual model
Authors: Sahli Farzane , Alidousti Sirous , Naghshineh Nader
Published: January 2022

The purpose of this review is to explore factors affecting brand building in libraries. Based on the nine steps of the National Health Service (NHS) center for reviews and dissemination, articles on the subject of library branding were searched in nine Iranian databases and seven international databases. The search period includes all date range of databases until 7–22 January 2021. The results were assessed for quality and 44 English articles and 3 Persian articles were selected for further analysis. Factors in promoting libraries brand building fall five categories. They include library architecture, library information resources and services, librarians’ personal branding, marketing, and library management. Inhibiting factors in libraries brand building have two final categories including internal and external inhibiting factors to brand building. Internal inhibitors covered branding costs, lead-time for branding, effort for branding and its management, the difficulty of strategic brand planning, and library staff unpreparedness. External inhibitors covered the difficulties of branding in the digital age and the economic situation of the country. If libraries manage their brand and move toward rebranding in line with the new information environment, they will be able to survive in today’s competitive world and build their true value in relationship with users.
Reaching into the basket of doom: Learning outcomes, discourse and information literacy
Authors: Hicks Alison , Lloyd Annemaree
Published: January 2022

Learning outcomes form a type of arrangement that holds the practice of information literacy within higher education in place. This paper employs the theory of practice architectures and a discourse analytical approach to examine the learning goals of five recent English-language models of information literacy. Analysis suggests that the practice of information literacy within higher education is composed of 12 common dimensions, which can be grouped into two categories, Mapping and Applying. The Mapping category encompasses learning outcomes that introduce the learner to accepted ways of knowing or what is valued by and how things work within higher education. The Applying category encompasses learning outcomes that encourage the learner to implement or integrate ideas into their own practice, including to their own questions, to themselves or to their experience. Revealing what is prioritised as well as what is less valued within the field at the present time, these findings also raise questions about supposed epistemological differences between models, the influence of research, and the language employed within these documents. This paper represents the third and final piece of work in a research programme that is interrogating the epistemological premises and discourses of information literacy within higher education.
Race/Ethnicity Differences in COVID-19 Vaccine Uptake Among Nurses
Authors: Choi Kristen , Rondinelli June , Cuenca Emma , Lewin Bruno , Chang John , Luo Yi X. , Bronstein David , Bruxvoort Katia
Published: January 2022

Introduction:

There is evidence for relatively lower COVID-19 vaccine uptake among people of color in the United States. The purpose of this study was to investigate associations between race/ethnicity and COVID-19 vaccine uptake among nurses.

Methods:

Nurses in Southern California ( N = 1183) completed a one-time, web-based survey to assess COVID-19 vaccine perceptions and uptake.

Results:

In all, 82.8% of respondents ( N = 979) received at least one COVID-19 vaccine dose. Identifying as East Asian was associated with 14% higher odds of COVID-19 vaccine uptake relative to identifying as White (odds ratio [OR] = 1.14/95% confidence interval [CI] = [1.06, 1.24]); identifying as Filipino was associated with 14% higher odds of uptake (OR = 1.14/95% CI = [1.08, 1.20]); and identifying as Hispanic/Latinx was associated with 6% higher odds of uptake (OR = 1.06/95% CI = [1.00, 1.12]).

Discussion:

Although nurses and people of color have been identified as groups with low levels of COVID-19 vaccine uptake, this study found that nurses of color received the vaccine at higher levels than their White counterparts.
A Retrospective Characterization of Dexmedetomidine-Suspected Fever and Its Consequences in Adult Critically Ill Patients
Authors: Schranz Emily , Rappaport Stephen , Groth Christine , Prasad Paritosh , Cooper Kevin , Connor Kathryn
Published: January 2022

Background:

Current evidence for dexmedetomidine-suspected fever (DSF) is limited. Lack of recognition may lead to costly or potentially harmful interventions for critically ill patients.

Objective:

The primary objective was to characterize escalations of care related to DSF. Secondary objectives were to describe the incidence, severity, and consequences associated with DSF.

Methods:

A retrospective review was conducted in critically ill adults who developed fever ≥39°C within 12 h from initiation of dexmedetomidine, with resolution of fever to <39°C within 12 h after discontinuation. The primary outcome was percentage of patients who received an escalation of care due to fever. Secondary outcomes included the percentage of patients who developed a multidrug-resistant organism or Clostridium difficile infection.

Results:

Eighteen of 3943 patients screened in 4099 encounters met criteria for DSF (0.4%). The majority were white (83.3%), male (66.7%), and underwent cardiac surgery (61.1%). Median (interquartile range [IQR]) time to fever onset and resolution were 5.5 (3.6-7.6) and 1.3 (1.0-2.9) h. Nine patients (50%) underwent infectious workup including antimicrobial initiation (n = 1, 5.6%), broadening of antimicrobials (n = 4, 22.2%), or culture collection (n = 9, 50%). Eleven patients (61.1%) underwent attempted temperature reduction. Twelve patients (66.7%) underwent diagnostic imaging. Incidence of multidrug-resistant organism and C. difficile infection were low (11.1 and 16.7% of fever patients, respectively).

Conclusion and Relevance:

Incidence of DSF was low and more common in cardiac surgery patients. Unrecognized DSF led to an escalation of care in most patients. Dexmedetomidine exposure should be considered as a potential cause of fever in critically ill adults.
Peer Support Experienced by Mothers of Children With Congenital Heart Defects in Sweden
Authors: Carlsson Tommy , Mattsson Elisabet
Published: January 2022

The aim of this study was to describe experiences of peer support among mothers of children with congenital heart defects. Ten mothers were interviewed through a semi-structured approach and interviews were analyzed with systematic text condensation. The respondents established various channels used for peer support and navigated between the channels depending on what type of information or support they needed. Through the channels, they found peers they developed strong friendships with and who they relied on for emotional support. Communicating with peers involved the reciprocal exchange of unique emotional support between peers who understand each other as well as the exchange of information derived from their collective knowledge, and thus, difficult to find without the help of peers. The findings illustrate the potential strengths of establishing reliable collaboration and liaisons between clinical units and peer support networks.
Association Between Pre-delivery Coagulation Indicators and Invasive Placenta Accreta Spectrum
Authors: Guo Zhirong , Han Xueyan , Zhang Huijing , Zheng Weiran , Yang Huixia , Ma Jingmei
Published: January 2022

Objectives

To analyze the association between pre-operational coagulation indicators and the severity of placenta accreta spectrum (PAS), as well as blood loss volume during operation.

Methods

Hospitalized patients of the obstetric department in a major hospital from 2018 to 2020 who were clinically and/or pathologically diagnosed with invasive PAS were included. Univariate and multivariate logistic regression and Poisson regression models were used to quantify the association between each of the 6 coagulation indicators and PAS severity (measured by FIGO grade) as well as maternal outcomes.

Results

Ninety-five patients (46 FIGO grade 2 and 49 FIGO grade 3) were included. Higher PT [adjusted OR (aOR): 5.54; 95% CI, 1.80 to 17.07] and FDP (aOR: 1.19; 95% CI, 1.01–1.42) levels were associated with an increased risk of FIGO grade 3 after adjusting for covariates. D-dimer [incidence rate ratio (IRR): 1.19; 95% CI, 1.05 to 1.35)] and FDP (IRR: 1.03; 95% CI, 1.01–1.04) levels were significantly associated with higher blood loss volume after adjusting for covariates.

Conclusion

Preoperative coagulation indicators, especially PT, D-dimer and FDP, are associated with disease severity and blood loss volume during operation of invasive PAS. The underlying mechanism for the coagulation profile of PAS patients warrants further analysis.

Synopsis

Preoperative coagulation indicators, especially PT, D-dimer and FDP, are associated with disease severity and blood loss volume during operation among invasive placenta accreta spectrum patients.
Development and Implementation of a Hybrid Online and In-Person Food Sovereignty and Nutrition Education Curriculum for Native American Parents: The FRESH Study
Authors: Haslam Alyson , Love Charlotte , Taniguchi Tori , Williams Mary B. , Wetherill Marianna S. , Sisson Susan , Weedn Ashley E. , Jacob Tvli , Blue Bird Jernigan Valarie
Published: January 2022

The Food Resource Equity and Sustainability for Health (“FRESH”) study is an Indigenous-led intervention to increase vegetable and fruit intake among Native American children. As part of this study, we developed a hybrid (online and in-person) food sovereignty and nutrition education curriculum for the parents of these children. This 16-week curriculum was developed to promote household- and community-level healthy eating and food sovereignty practices to parents of preschool-aged children residing in Osage Nation, Oklahoma. A total of 81 parent/caregivers participated in the curriculum component of the FRESH study, with a median age of 34 years (range: 23–54 years). Most study participants were female (88.9%) and less than half (45.7%) had an annual household income of more than US$50,000. Most were married or had a significant other (76.5%) and worked full-time (65.4%). The median total number of children in the home <18 years of age was three (range: 1–8). Participation among the 94 parents was 56% during the first week and was 12% in the final week. Having some college or technical training (vs. having a college degree) and having an annual household income of US$20,000–US$50,000 (vs. more than US$50,000) were associated with fewer sessions attended ( p = 0.004 and 0.02, respectively) Being married (vs. not) was associated with higher attendance ( p < .0001). Participation in a hybrid food sovereignty and nutrition education curriculum for parents was generally low, but income, education, and marital status were associated with curriculum participation. Our research adds to the literature by describing the development and implementation of this curriculum and recommendations for future research incorporating Indigenous approaches to health.
Drinking Water Source, Chlorinated Water, and Colorectal Cancer: A Matched Case-Control Study in Ethiopia
Authors: Tafesse Nebiyou , Porcelli Massimiliano , Robele Gari Sirak , Ambelu Argaw
Published: January 2022

Background:

There is no study conducted on the association between disinfection byproducts (DBPs) in chlorinated drinking water and colorectal cancer (CRC) in Ethiopia. Therefore, this study aimed to determine the relation between chlorine based DBPs in drinking water and CRC in Addis Ababa, Ethiopia.

Methods:

A facility based matched case control study was conducted involving 224 cases and 448 population controls from June 2020 to May 2021. Cases were defined as histologically confirmed CRC cases. Cases were matched with controls by residence, age, and sex using frequency and individual matching. Geocoding of cases, health facility, and georeferencing of controls were carried out. Data was collected using a pretested structured questionnaire. Pearson Chi square and Fisher’s exact tests were employed to assess associations. Stratified analysis was used to detect confounding factors and effect modification. A multivariable conditional logistic regression was used to identify risk factors of CRC.

Results:

Of 214 CRC cases, 148 (69.2%) used chlorinated water whereas out of 428 controls 161 (37.6%) used chlorinated water. In the final regression model, drinking chlorinated surface water (adjusted matched odds ratio [adjusted mOR] = 2.6; 95% CI 1.7-4.0), history of swimming (adjusted mOR = 2.4; 95% CI 1.4-4.1), years at the place of current residence (adjusted mOR = 1.5; 95% CI 1.1-2.2), hot tap water use for showering (adjusted mOR; 3.8 = 95% CI 2.5-5.9) were significantly associated with CRC. The stratified analysis confirmed that smoking and meat ingestion were not effect modifiers and confounders.

Conclusion:

Drinking chlorinated water for extended years is a significant risk factor for CRC in Addis Ababa, Ethiopia. In addition, hot tap water use for showering, and swimming history are risk factors for CRC. This information is essential to design integrated interventions that consider chlorination by-products and exposure routes toward the prevention and control of CRC in Ethiopia. Initiating alternative methods to chlorine disinfection of drinking water is also essential.
Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data
Authors: Dattilo Maurizio , Fontanarosa Carolina , Spinelli Michele , Bini Vittorio , Amoresano Angela
Published: January 2022

Background:

Hydrogen sulfide (H2S) is a pivotal gasotransmitter networking with nitric oxide (NO) and carbon monoxide (CO) to regulate basic homeostatic functions. It is released by the alternative pathways of transulfuration by the enzymes Cystathionine Beta Synthase (CBS) and Cystathionine Gamma Lyase (CSE), and by Cysteine AminoTransferase (CAT)/ 3-Mercaptopyruvate Sulfur Transferase (3MPST). A non-enzymatic, intravascular release is also in place. We retrospectively investigated the possibility to modulate the endogenous H2S release and signaling in humans by a dietary manipulation with supplemented micronutrients (L-cystine, Taurine and pyridoxal 5-phopsphate/P5P).

Methods:

Patients referring for antiaging purposes underwent a 10-day supplementation. Blood was collected at baseline and after treatment and the metabolome was investigated by mass spectrometry to monitor the changes in the metabolites reporting on H2S metabolism and related pathways.

Results:

Data were available from 6 middle aged subjects (2 women). Micronutrients increased 3-mercaptopyruvate ( P = .03), reporting on the activity of CAT that provides the substrate for H2S release within mitochondria by 3MPST, decreased lanthionine ( P = .024), reporting the release of H2S from CBS, and had no significant effect of H2S release from CSE. This is compatible with a homeostatic balancing. We also recorded a strong increase of reporters of H2S-induced pathways including 5-MethylTHF ( P = .001) and SAME ( P = .022), reporting on methylation capacity, and of BH4 ( P = .021) and BH2 ( P = .028) reporting on nitric oxide metabolism. These activations may be explained by the concomitant induction of non-enzymatic release of H2S.

Conclusions:

Although the current evidences are weak and will need to be confirmed, the effect of micronutrients was compatible with an increase of the H2S endogenous release and signaling within the control of homeostatic mechanisms, further endorsing the role of feeding in health and disease. These effects might result in a H2S boosting effect in case of defective activity of pathologic origin, which should be checked in duly designed clinical trials.
E-cigarette Use Among Middle and High School Students in New York City Before and After Passage of Tobacco 21
Authors: Debchoudhury Indira , Farley Shannon M , Roods Kristi , Talati Achala , Jasek John
Published: January 2022

Introduction

Despite declines in cigarette smoking in the US, electronic cigarette (e-cigarette) use has increased among middle and high school students. In 2014, New York City (NYC) implemented Tobacco 21 (T21) to prohibit sales to anyone under age 21. Our study goal was to measure the effectiveness of T21 on e-cigarette use.

Methods

We used the New York State (NYS) Youth Tobacco Survey—a biennial, school-based, self-administered survey. We explored middle (N = 5249) and high (N = 7296) school NYC students’ (male and female) current (past 30 days’) e-cigarette use from 2014 (pre-T21) to 2018 (post-T21). Results were compared with students in the rest of NYS (ROS). Bivariate and multivariable logistic regression analyses assessed correlates of e-cigarette use, beliefs about harmfulness, addictiveness, and susceptibility.

Results

NYC high school students’ current e-cigarette use increased from 2014 to 2018 (8.1% vs 23.5%, P < .001). Middle school students’ use increased between 2014 (4.8%) and 2016 (9.0%) yet reversed by 2018 (5.7%) (2014 vs 2018, P = .576). ROS middle school (2.2% vs 7.4%, P < .001) and high school (12.0% vs 29.3%, ( P < .001) use increased from 2014 to 2018. Willingness to try e-cigarettes among those who had never tried an e-cigarette was twice as high (AOR = 2.19, 95% CI = 1.15-3.17) among NYC high school students in 2018 compared with 2014.

Conclusions

E-cigarette use increased among NYC high school students despite T21. T21 may have reduced use among middle school students over time. Programs that denormalize e-cigarettes and policies that further restrict access are needed to decrease youth e-cigarette use.
An exploration of the structural and colligational characteristics of lexical bundles in L1–L2 corpora for English language teaching
Authors: Dahunsi Toyese Najeem , Ewata Thompson Olusegun
Published: January 2022

Multi-word expressions are formulaic language universals with arbitrary and idiosyncratic collocations. Their usage and mastery are required of learners of a second language in achieving naturalness. However, despite the importance of multi-word expressions to mastering a second language, their syntactic architecture and colligational possibilities have received little attention in English language teaching (ELT). This study examined lexical bundles, a type of multi-word expressions, to understand their structure and co-occurrence possibilities with other syntactic elements. It was aided by an automated frequency-driven approach using two corpora, the British component of the British National Corpus – a first language (L1) corpus – and a purpose-built Nigerian Media Discourse corpus – a second language (L2) corpus. Two items of lexical analysis software were used to extract three-word lexical bundles with a minimum of 50 frequencies per corpus. The syntactic structures of the identified lexical bundles were determined, and their in-corpus usages were analysed for their colligational characteristics. Results showed that both corpora had instances of general and genre-specific lexical bundles (LBs) with varying frequencies. Five categories of lexical bundles with different structural patterns and peculiar colligational characteristics were identified in the study. Since lexical bundles are more frequently found in both L1–L2 texts, mastering how they are used will further enhance the teaching of English as a second language. The teaching of lexical bundles as a multi-word expression is therefore recommended in ELT as a way of enhancing learners’ proficiency and naturalness in English.
Sufficient sleep duration in autistic children and the role of physical activity
Authors: Elkhatib Smidt Stacey D , Gooneratne Nalaka , Brodkin Edward S , Bucan Maja , Mitchell Jonathan A
Published: January 2022

Emerging evidence suggests that physical activity may be associated with improved sleep in autistic children. We aimed to determine whether physical activity associated with sufficient sleep duration in children and whether this association was modified by reported autism spectrum disorder (ASD) status. We analyzed existing data of children 6–17 years old whose caregivers completed the 2018 National Survey of Children’s Health (nonautistic N = 20,845; ASD N = 681). Logistic regression determined whether physical activity (days active in the past week) associated with sufficient sleep duration. Physical activity-by-ASD interactions were included to determine whether the association differed for autistic children. Physical activity-by-ASD-by-sex and physical activity-by-ASD-by-age-group interactions were also modeled. Physical activity was associated with increased odds of sufficient sleep duration (e.g. 0 days vs 4–6 days: odds ratio (OR) = 1.85; 95% confidence interval (CI): 1.48–2.32). We did not observe an overall statistically significant interaction between physical activity and reported ASD status; however, the positive association between physical activity and sufficient sleep duration was weaker in autistic children, especially those with more severe ASD, female autistic children, and autistic children ages 6–12 years old. In conclusion, physical activity is a promising approach to improve sufficient sleep duration but with nuanced findings in autistic children.

Lay abstract

Higher levels of physical activity may be associated with improved sleep in children, but this relationship is still being determined, especially in autistic children. In this study, we used existing data from the 2018 National Survey of Children’s Health. Caregivers of children 6–17 years old, including caregivers of autistic children, completed a questionnaire that included questions about physical activity (days active in the past week) and sleep duration. We then determined if children were obtaining the recommended hours of sleep for their age (i.e. sufficient sleep). We found that higher physical activity levels were associated with sufficient sleep duration, but this finding was weaker in autistic children. In particular, this association was not observed in autistic children with more severe autism spectrum disorder, female autistic children, and autistic children 6–12 years old. In conclusion, physical activity is a promising approach to help children obtain sufficient sleep duration. However, more personalized approaches to improving sleep may be needed for certain groups of autistic children.
Damage detection in bridges under moving loads based on subspace projection residuals
Authors: Nie Zhenhua , Xie Yongkang , Li Jun , Hao Hong , Ma Hongwei
Published: January 2022

This paper proposes a data-driven method using subspace projection residual of the responses to identify the damage locations in bridges subjected to moving loads. In this method, a moving window with a certain length determined by the sampling frequency and the fundamental frequency of the measured responses is used to cut out the acceleration responses of the bridge subjected to a moving vehicle. The characteristic subspaces of the windowed signals are subsequently extracted to calculate the local damage index using the subspace projection residual. When the window moves to the damage location, the orthogonality between the active subspace of the damaged state and the null subspace of the healthy state is invalid, which leads to a relatively large projection residual that can be used to localize the damage. To improve the reliability of the proposed approach, a one-side upper confidence limit is introduced. A simply supported beam bridge subjected to a moving mass is simulated to verify the effectiveness of the proposed method. Numerical results indicate that the proposed approach can accurately localize the single and multiple damages, even when the responses are smeared with a significant noise. Experimental tests conducted on a steel beam bridge model also demonstrate the performance and accuracy of the proposed approach. The results demonstrate that the proposed method can localize the damage even with a small number of sensors, indicating the method has a good and promising performance for practical engineering applications.
Modal analysis and demonstration of metastructure combining local resonators and an autonomous synchronized switch damping circuit
Authors: Asanuma Haruhiko , Yamauchi Sumito
Published: January 2022

A locally resonant metastructure is a promising approach for low-frequency vibration attenuation, whereas the attachment of many resonators results in unnecessary and multiple resonance outside the bandgap. To address this issue, we propose a damping metastructure combining local resonators and an autonomous synchronized switch damping circuit. On the basis of modal analysis, we derive an electromechanically coupled equation of the proposed metastructure. The piezo ceramics, which are attached on a small portion of the metastructure and connected to the circuit, remarkably decrease the magnitude of the resonant vibration with no extra sensors, signal processors, or power sources. The displacement at unnecessary resonance was decreased by approximately 75%. The results of the coupled analysis were similar to the experimentally observed results in terms of the location and width of the bandgap on the frequency axis and the decreased displacement for the circuit. The proposed technique can overcome the disadvantage of the metastructure.
Modeling and simulation of marine SCR system based on Modelica
Authors: Shi Jie , Zhu Yuanqing , Peng Hui , Yan Haoyu , Li Tinghui , Zhang Jin , Zhou Song
Published: January 2022

With the increasing awareness of global marine environmental protection, the emission of ship exhaust pollutants is strictly restricted. Selective catalytic reduction (SCR) technology is the mainstream technology to reduce ship NOx emission and make it meet IMO tier III regulations. A SCR reaction kinetic model based on Modelica language was established by Dymola software to predict the denitration efficiency, ammonia slip rate, and other parameters of SCR system. According to the functional structure of marine SCR system, the SCR system model is divided into urea injection module, mixer module, and SCR reactor module. The model was verified by SCR system bench test of WD10 diesel engine, which proved that the model can preferably reflect the actual situation. Using the established model, the effects of temperature, flow rate, NH3/NOx Stoichiometric Ratio (NSR), and cell density on the denitration performance of SCR system were analyzed. The results showed that the exhaust gas temperature and NSR have a great influence on the denitration efficiency. The injection amount of urea solution in marine SCR system should be based on the exhaust gas temperature and exhaust flow rate.
Walking through the city soundscape: an audio-visual analysis of sensory experience for people with psychosis
Authors: Merlino Sara , Mondada Lorenza , Söderström Ola
Published: January 2022

This article discusses how an aspect of urban environments – sound and noise – is experienced by people walking in the city; it particularly focuses on atypical populations such as people diagnosed with psychosis, who are reported to be particularly sensitive to noisy environments. Through an analysis of video-recordings of naturalistic activities in an urban context and of video-elicitations based on these recordings, the study details the way participants orient to sound and noise in naturalistic settings, and how sound and noise are reported and reexperienced during interviews. By bringing together urban context, psychosis and social interaction, this study shows that, thanks to video recordings and conversation analysis, it is possible to analyse in detail the multimodal organization of action (talk, gesture, gaze, walking bodies) and of the sensory experience(s) of aural factors, as well as the way this organization is affected by the ecology of the situation.
Spaces of exposure: Re-thinking ‘publicness’ through public transport
Authors: Kemmer Laura , Sgibnev Wladimir , Weicker Tonio , Woods Maxwell
Published: January 2022

Developing thoughts on exposure in cultural geography, literary studies, and mobilities research, this article aims to provide a more comprehensive account towards the publicness of public space. What would happen if we assessed publicness not by degrees of openness and inclusion, but through the nexus of vulnerability and complicity that is fundamental to the notion of exposure? To grasp such an intrinsic dualism, our perspective goes towards public transport, where experiences of exposure are intensified by its specific conditions of encapsulation and movement. We illustrate this perspective drawing from the autobiographical chronicles of the Chilean writer Pedro Lemebel, in order to then propose a ‘learning from’ the case of public transport for a rethinking of publicness. Specifically, we argue that exposure provides new insights on agency, power and vulnerability as part of a more processual notion of public space.
Patient-related outcomes in patients referred to a respiratory clinic with persisting symptoms following non-hospitalised COVID-19
Authors: Harvey-Dunstan Theresa C , Jenkins Alex R , Gupta Ayushman , Hall Ian P , Bolton Charlotte E
Published: January 2022

Survivors of COVID-19 can present with varied and persisting symptoms, regardless of hospitalisation. We describe the ongoing symptoms, quality of life and return to work status in a cohort of non-hospitalised COVID-19 survivors with persisting respiratory symptoms presenting to clinic, who consented and completed patient-reported outcome measures. We identified fatigue, reduced quality of life and dysregulated breathing alongside the breathlessness. Those with co-existent fatigue had worse mood and quality of life and were less likely to have returned to normal working arrangements compared to those without fatigue. For non-hospitalised people with persisting symptoms following COVID-19 referred to a respiratory assessment clinic, there was a need for a wider holistic assessment, including return to work strategies.