bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase III Study of Matrix Metalloproteinase Inhibitor Prinomastat in Non–Small-Cell Lung Cancer
Authors: Bissett Donald , O’Byrne Ken J. , von Pawel J. , Gatzemeier Ulrich , Price Allan , Nicolson Marianne , Mercier Richard , Mazabel Elva , Penning Carol , Zhang Min H. , Collier Mary A. , Shepherd Frances A.
Published: January 2005

Purpose

Matrix metalloproteinases (MMPs) degrade extracellular proteins and facilitate tumor growth, invasion, metastasis, and angiogenesis. This trial was undertaken to determine the effect of prinomastat, an inhibitor of selected MMPs, on the survival of patients with advanced non–small-cell lung cancer (NSCLC), when given in combination with gemcitabine-cisplatin chemotherapy.

Patients and Methods

Chemotherapy-naive patients were randomly assigned to receive prinomastat 15 mg or placebo twice daily orally continuously, in combination with gemcitabine 1,250 mg/m2 days 1 and 8 plus cisplatin 75 mg/m2 day 1, every 21 days for up to six cycles. The planned sample size was 420 patients.

Results

Study results at an interim analysis and lack of efficacy in another phase III trial prompted early closure of this study. There were 362 patients randomized (181 on prinomastat and 181 on placebo). One hundred thirty-four patients had stage IIIB disease with T4 primary tumor, 193 had stage IV disease, and 34 had recurrent disease (one enrolled patient was ineligible with stage IIIA disease). Overall response rates for the two treatment arms were similar (27% for prinomastat v 26% for placebo; P = .81). There was no difference in overall survival or time to progression; for prinomastat versus placebo patients, the median overall survival times were 11.5 versus 10.8 months (P = .82), 1-year survival rates were 43% v 38% (P = .45), and progression-free survival times were 6.1 v 5.5 months (P = .11), respectively. The toxicities of prinomastat were arthralgia, stiffness, and joint swelling. Treatment interruption was required in 38% of prinomastat patients and 12% of placebo patients.

Conclusion

Prinomastat does not improve the outcome of chemotherapy in advanced NSCLC.
Breast Cancer Treatment Guidelines in Older Women
Authors: Giordano Sharon H. , Hortobagyi Gabriel N. , Kau Shu-Wan C. , Theriault Richard L. , Bondy Melissa L.
Published: January 2005

Purpose

To determine patterns and predictors of concordance with institutional treatment guidelines among older women with breast cancer.

Methods

The study population included 1,568 patients aged 55 years and older who were treated at M.D. Anderson Cancer Center between July 1997 and January 2002 for stage I to IIIA invasive ductal and lobular breast cancer. Concordance with institutional guidelines was determined for definitive surgical therapy, radiotherapy after breast-conserving surgery, radiation therapy after mastectomy, adjuvant chemotherapy use, and adjuvant hormonal therapy use. The following variables were considered as possible modifiers of concordance: patient age, marital status, race, educational level, Eastern Cooperative Oncology Group performance status, comorbidity score, clinical stage, hormone receptor status, HER2-neu status, tumor grade, pathologic tumor size, lymphatic invasion, and number of lymph nodes involved. Logistic regression modeling was performed to determine the independent effect of each variable on guideline concordance.

Results

Older women were less likely to receive treatment in concordance with guidelines for definitive surgical therapy (P < .001), postlumpectomy radiation (P = .03), adjuvant chemotherapy (P < .001), and adjuvant hormonal therapy (P < .001). In multivariate analysis, age ≥ 75 years predicted a deviation from guidelines for definitive surgical therapy, adjuvant chemotherapy, and adjuvant hormonal therapy. Nonwhite race was associated with decreased likelihood of adjuvant radiation therapy after breast conservation.

Conclusion

After adjustment for comorbidity score, race, marital status, educational status, clinical stage, and tumor characteristics, increasing patient age was independently associated with decreased guideline concordance for definitive surgery, adjuvant chemotherapy, and adjuvant hormonal therapy. Future research should focus on delineating the possible reasons for guideline discordance.
EGFR Mutations in Non–Small-Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic Treatment
Authors: Marchetti Antonio , Martella Carla , Felicioni Lara , Barassi Fabio , Salvatore Simona , Chella Antonio , Camplese Pier P. , Iarussi Teodorico , Mucilli Felice , Mezzetti Andrea , Cuccurullo Franco , Sacco Rocco , Buttitta Fiamma
Published: January 2005

Purpose

It has been reported that EGFR mutations in lung carcinomas make the disease more responsive to treatment with tyrosine kinase inhibitors. We decided to evaluate the prevalence of EGFR mutations in a large series of non–small-cell lung carcinomas (NSCLCs) and to develop a rapid and sensitive screening method.

Patients and Methods

We examined 860 consecutive NSCLC patients for EGFR mutations in exons 18, 19, and 21 using a dual technical approach—direct sequencing of polymerase chain reaction (PCR) products and PCR single-strand conformation polymorphism (SSCP) analysis. Moreover, all lung adenocarcinomas were analyzed for K-ras mutations at codon 12 by allele-specific oligoprobe hybriditations.

Results

There were no EGFR mutations in 454 squamous carcinomas and 31 large cell carcinomas investigated. Thirty-nine mutations were found in the series of 375 adenocarcinomas (10%). Mutations were present in 26% of 86 bronchioloalveolar carcinomas (BACs) and in 6% of 289 conventional lung adenocarcinomas; P = .000002. EGFR mutations and K-ras mutations were mutually exclusive. A multivariable analysis revealed that BAC histotype, being a never smoker, and female sex were independently associated with EGFR mutations (odds ratios: 4.542, 3.632, and 2.895, respectively). The SSCP analysis was accurate and sensitive, allowing identification of mutations that were undetectable (21% of cases) by direct sequencing.

Conclusion

Mutations in the EGFR tyrosine kinase domain define a new molecular type of lung carcinoma, more frequent in particular subsets of patients. The SSCP assay is a rapid and reliable method for the detection of EGFR kinase domain mutations in lung cancer.
Phenotypic Heterogeneity in Multiple Myeloma Families
Authors: Lynch Henry T. , Watson Patrice , Tarantolo Stefano , Wiernik Peter H. , Quinn-Laquer Brigid , Isgur Bergsagel Karin , Huiart Laetitia , Olopade O.I. , Sobol Hagay , Sanger Warren , Hogg David , Weisenburger Dennis
Published: January 2005

Purpose

To describe a series of families with familial multiple myeloma (MM). Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM.

Patients and Methods

This observational study consisted of 39 families with multiple cases of MM or related disorders from four collaborating research centers. Each center followed its usual family study method. Probands were interviewed, and, when possible, cancers were verified by medical records and pathology review. A working pedigree was compiled on each family.

Results

Seventeen families had affected members in two or more generations, and eight families had two or more affected members in a single generation. Four families had two or more members with plasma cell dyscrasias, with or without a single case of MM. In the remaining 10 families, a single MM case occurred with a family history of other cancers. Other cancers observed in family members included hematologic malignancies and solid tumors. In families with MM in multiple generations, there was a decrease in the age at MM diagnosis in successive generations.

Conclusion

The study of familial MM may provide insights into the pathogenesis and, ultimately, the control and prevention of MM and related disorders. Population-based epidemiologic studies are crucial, but because of the rarity of familial MM, a concerted case-finding approach may also be fruitful. Therefore, we propose an international consortium to study familial MM, and we invite all interested colleagues to participate.
Relationship Between MYCN Copy Number and Expression in Rhabdomyosarcomas and Correlation With Adverse Prognosis in the Alveolar Subtype
Authors: Williamson Daniel , Lu Yong-Jie , Gordon Tony , Sciot Raf , Kelsey Anna , Fisher Cyril , Poremba Christopher , Anderson John , Pritchard-Jones Kathy , Shipley Janet
Published: January 2005

Purpose

Amplification of the transcription factor MYCN is an important molecular diagnostic tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression of MYCN in the pediatric cancer rhabdomyosarcoma has been described in a number of small studies with conflicting conclusions about its association with clinicopathologic characteristics. We aimed to study the phenomenon in the largest series to date.

Patients and Methods

Using quantitative polymerase chain reaction, we measured MYCN copy number and expression levels in rhabdomyosarcoma samples from 113 and 92 individuals with a confirmed diagnosis of rhabdomyosarcoma, respectively.

Results

Increased copy number of MYCN was found to be a feature of both the embryonal and alveolar subtypes. The copy number and expression levels were significantly greater in the alveolar subtype, although the range of expression in both subtypes spanned several orders of magnitude. MYCN copy number showed a significant correlation with expression in the alveolar subtype; this relationship between copy number and expression could be modeled as a logarithmic function. It is notable that relatively high expression frequently occurred in embryonal rhabdomyosarcoma without high copy number and that low expression was found in some cases with high copy number. In patients with alveolar rhabdomyosarcoma, overexpression (greater than median) or gain of genomic copies of MYCN were significantly associated with adverse outcome.

Conclusion

MYCN deregulation is a feature of rhabdomyosarcoma tumorigenesis, defines groups of patients with a poor prognosis, and is a potential target for novel therapies.
Immunoassay for Sex Hormone-Binding Globulin in Undiluted Serum Is Influenced by High-Molecular-Mass Aggregates
Authors: Thaler Markus , Metzger Jochen , Schreiegg Anita , Denk Barbara , Gleixner Andreas , Hauptmann Hagen , Luppa Peter B
Published: January 2005

Background: The new Elecsys® chemiluminescence assay for measurement of homodimeric sex hormone-binding globulin (SHBG) was designed for use with undiluted serum, in contrast to other methods that require predilution. During assay development, unexpected calibration difficulties were observed that were attributable to particular biochemical properties of the highly concentrated SHBG in solution.

Methods: We used a surface plasmon resonance (SPR) biosensor, which enables biomolecular interaction analysis of SHBG, and size-exclusion chromatography for this investigation. The immunoassay was evaluated for imprecision, linearity, and suitability of the dilution medium, and the method was compared with an IRMA for SHBG.

Results: The SPR biosensor characterized the special protein properties of SHBG in various concentrations. Above 200 nmol/L there was a strong tendency toward formation of high-molecular-mass aggregates. This was also detectable by size-exclusion chromatography and could be reversed by simple dilution of the sample. On the basis of these results, the dynamic measuring range of the SHBG assay is restricted to 0.350–200 nmol/L. Assay evaluation on a 2010 analyzer revealed excellent precision (CV ≤2.5%). Mean recoveries were 84.2–98.8%. Intermethod comparison with an IRMA yielded a satisfactory concordance of the two assays with a Spearman correlation coefficient of 0.8807.

Conclusions: Aggregates of human SHBG may have a detrimental impact on the accurate measurement of the protein if measurements are performed with undiluted serum samples. Further work is needed to clarify whether these high-molecular-mass aggregates influence the free fraction of steroid hormones in vivo.
Amitriptyline or Not, That Is the Question: Pharmacogenetic Testing of CYP2D6 and CYP2C19 Identifies Patients with Low or High Risk for Side Effects in Amitriptyline Therapy
Authors: Steimer Werner , Zöpf Konstanze , von Amelunxen Silvia , Pfeiffer Herbert , Bachofer Julia , Popp Johannes , Messner Barbara , Kissling Werner , Leucht Stefan
Published: January 2005

Background: Amitriptyline has been replaced in many countries by alternative and more expensive drugs based on claims of improved tolerability and toxicity and despite slightly reduced efficacy. Preliminary studies indicate that adverse effects could be linked to polymorphisms of drug-metabolizing enzymes, but information on their clinical impact remains scanty and includes mainly case reports. We conducted a prospective blinded two-center study seeking correlations between CYP2C19 and CYP2D6 genotypes, drug concentrations, adverse events, and therapy response.

Methods: Fifty Caucasian inpatients with at least medium-grade depressive disorder received amitriptyline at a fixed dose of 75 mg twice a day. Blood samples for concentration monitoring of amitriptyline and nortriptyline were taken weekly until discharge along with evaluations of depression (Hamilton Depression Scale and Clinical Global Impression Scale) and side effect (Dosage Record and Treatment Emergent Symptoms Scale; DOTES) scores.

Results: In a ROC analysis, nortriptyline but not amitriptyline concentrations correlated with side effects (DOTES sum score ≥5; area under the curve, 0.733; P = 0.008). Carriers of two functional CYP2D6 alleles had a significantly lower risk of side effects than carriers of only one functional allele (12.1% vs 76.5%; P = 0.00001). The lowest risk was observed for carriers of two functional CYP2D6 alleles combined with only one functional CYP2C19 allele [0 of 13 (0%) vs 9 of 11 (81.8%) for the high-risk group; P = 0.00004]. We found no correlations between drug concentrations or genotypes and therapeutic response.

Conclusions: Combined pharmacogenetic testing for CYP2D6 and CYP2C19 identifies patients with low risk for side effects in amitriptyline therapy and could possibly be used to individualize antidepressive regimens and reduce treatment cost. Identification of genotypes associated with slightly reduced intermediate metabolism may be more important than currently anticipated. It could also be the key to demonstrating cost-effectiveness for CYP2D6 genotyping in critical dose drugs.
Screening for Primary Aldosteronism in Essential Hypertension: Diagnostic Accuracy of the Ratio of Plasma Aldosterone Concentration to Plasma Renin Activity
Authors: Schwartz Gary L , Turner Stephen T
Published: January 2005

Background: The ratio of plasma aldosterone concentration to plasma renin activity (PRA) is considered the screening test of choice for primary aldosteronism. Uncertainty exists, however, regarding its diagnostic accuracy and the effects of antihypertensive drugs and dietary sodium balance on test characteristics.

Methods: We measured PRA and aldosterone in 118 white adults [71 men and 47 women; mean (SD) age, 51 (7) years] with previously diagnosed essential hypertension. Measurements were made while individuals were on antihypertensive drug therapy, after a 2-week drug-free period, after 4 days of dietary sodium loading, and after acute furosemide diuresis. We measured 24-h urine aldosterone excretion and PRA on the 4th day of dietary sodium loading to establish the diagnosis of primary aldosteronism. ROC curves were constructed for ratios measured under each clinical condition, and likelihood ratios were determined for individuals on or off antihypertensive drug therapy.

Results: Fifteen patients [13%; 95% confidence interval (CI), 7–20%] met the reference standard for primary aldosteronism. The mean (SD) areas under the ROC curves did not differ significantly across conditions of measurement [range, 0.80 (0.10) to 0.85 (0.04); P = 0.72]. When measured on and off antihypertensive drug therapy, the 95% CIs for the optimum cutpoint for the ratio overlapped. Point estimates of sensitivity on and off therapy were 73% (95% CI, 50–96%) and 87% (70–100%), respectively, and specificities were 74% (65–83%) and 75% (66–84%). Under either condition, increased ratios were associated with 2.4- to 13-fold increases of posttest odds above pretest odds.

Conclusions: The aldosterone:PRA ratio provides only fair diagnostic accuracy in screening for primary aldosteronism, but concomitant antihypertensive drug therapy or acute variation in dietary sodium balance does not adversely affect test accuracy. Reporting of likelihood ratios associated with ranges of values of the aldosterone:PRA ratio, rather than use of a single “optimum” cutpoint, may enhance the usefulness of the test.
Jews, Multiculturalism, and Boasian Anthropology
Authors: Frank Gelya
Published: January 2005

Standard histories of American anthropology have downplayed the preponderance of Jewish intellectuals in the early years of Boasian anthropology and the Jewish identities of later anthropologists. Jewish histories, however, foreground the roles and deeds of Jews. This essay brings together these various discourses for a new generation of American anthropologists, especially those concerned with turning multiculturalist theories into agendas for activism. Although Boas's anthropology was apolitical in terms of theory, in message and purpose it was an antiracist science.
Christians, Jews, and the Other in German Anthropology
Authors: Hauschild Thomas
Published: January 2005

National anthropologies, wrote George Stocking, can be seen as little "nations" that develop their own foreign policies, formulating distinctions between "us" and "them." American and German anthropological nations were both built on literary traditions of primitivism and exoticism, and both exalted the idea of culture. But they developed very different policies toward their interior others. The Indian was the romanticized precursor to American civilization, while the sophisticated, and thus more dangerous, other lay outside the borders. German Jews, because they participated in German intellectual life, were sophisticated internal savages and hence the most dangerous enemy.
Missionary Encounters: Histories and Memoirs
Authors: Poewe Karla
Published: January 2005

Alexander Merensky: Erinnerungen aus dem Missionsleben in Transvaal (Südafrika) 1859 bis 1882. Ulrich van der Heyden. ed. Cognoscere, 5. Berlin: Edition Ost, 1996.560 pp.

Hate the Old and Follow the New: Khoekhoe and Missionaries in Early Nineteenth‐Century Namibia. Tilman Dedering. Stuttgart, Germany: Franz Steiner Verlag, 1997. 205 pp.
The Common Ground of Contested Space: Historical Archaeology and American Landscapes
Authors: Rubertone Patricia E.
Published: January 2005

Landscape Archaeology: Reading and Interpreting the American Historical Landscape. Rebecca Yamin and Karen Bescherer Metheny, eds. Knoxville: University of Tennessee Press, 1996. 292 pp.

Culture Change and the New Technology: An Archaeology of the Early American Industrial Era. Paul A. Shackel. New York: Plenum Press, 1996. 217 pp.
Political Violence and the Politics of Ethnography
Authors: Dusenbery Verne A.
Published: January 2005

The Sikhs of the Punjab: Unheard Voices of State and Guerrilla Violence. Joyce J. M. Pettigrew. Atlantic Highlands, NJ: Zed Books, 1995. 212 pp.

Fighting for Faith and Nation: Dialogues with Sikh Militants. Cynthia Keppley Mahmood. Philadelphia: University of Pennsylvania Press, 1996.314 pp.
Other Anthropological Traditions: Japan
Authors: Ohnuki‐Tierney Emiko
Published: January 2005

Kegare no minzokushi: Sabetsu no bunkateki yôin (Anthropology of impurity: Cultural bases of social discrimination). Noboru Miyata. Tokyo: Jinmon Shoin. 1996.
The Culture of Science in the Late 20th Century
Authors: Fischer Michael M. J.
Published: January 2005

Modest_Witness@Second_Millmnium:.FemaleMan©_ Meets OncoMouse™_Feminism and Technoscience. Donna Haraway. With paintings by Lynn M. Randolph. New York: Routledge, 1997. 361 pp.
Explorations in Southeastern Archaeology
Authors: Peebles Christopher S.
Published: January 2005

The Paleoindian and Early Archaic Southeast. David G. Anderson and Kenneth E. Sassaman. eds. Tuscaloosa: University of Alabama Press, 1996. 526 pp.

Native American Interactions: Multiscalar Analyses and Interpretations in the Eastern Woodlands. Michael S. Nassaney and Kenneth E. Sassaman. eds. Knoxville: University of Tennessee Press, 1995. 376 pp.
A Place against Time: Land and Environment in the Papua New Guinea Highlands
Authors: Moran Emilio F.
Published: January 2005

Place against Time: Land and Environment in the Papua New Guinea Highlands. Paul Sillitoe. London: Harwood Academic Publishers, 1996. 438 pp.
The Channeling Zone: American Spirituality in an Anxious Age
Authors: Hess David J.
Published: January 2005

The Channeling Zone: American Spirituality in an Anxious Age. Michael F. Brown. Cambridge, MA: Harvard University Press, 1997. 236 pp.
The Mexican Outsiders: A Community History of Marginalization and Discrimination
Authors: Wilson Tamar Diana
Published: January 2005

The Mexican Outsiders:. Community History of Marginalization and Discrimination. Martha Menchaca. Austin: University of Texas Press, 1995. 250 pp.
Mayan Tales from Zinacantan: Dreams and Stories from the People of the Bat
Authors: Herrera Juan Felipe
Published: January 2005

Mayan Tales from Zinacantan: Dreams and Stories from the People of the Bat. Robert M. Laughlin. trans. Carol Karasik, ed. Washington, DC: Smithsonian Institution Press, 1997. 282 pp.
Women of Belize: Gender and Change in Central America
Authors: Bonner Donna
Published: January 2005

Women of Belize: Gender and Change in Central America. Irma McClaurin. New Brunswick, NJ: Rutgers University Press, 1996.218 pp.
The Vulnerable Observer: Anthropology That Breaks Your Heart
Authors: Turner Edith
Published: January 2005

The Vulnerable Observer: Anthropology That Breaks Your Heart. Ruth Behar. Boston, MA: Beacon Press, 1996. 196 pp.
South Pacific Oral Traditions
Authors: Turner James W.
Published: January 2005

South Pacific Oral Traditions. Ruth Finnegan and Margaret Orbell. eds. Bloomington: Indiana University Press, 1995.259 pp.
Economies and Cultures: Foundations of Economic Anthropology
Authors: Halperin Rhoda H.
Published: January 2005

Economies and Cultures: Foundations of Economic Anthropology. Richard R. Wilk. Boulder, CO: Westview Press, 1996. 189 pp.
The Macedonian Conflict: Ethnic Nationalism in a Transnational World
Authors: Schwartz Jonathan M.
Published: January 2005

The Macedonian Conflict: Ethnic Nationalism in. Transnational World. Loring M. Danforth. Princeton, NJ: Princeton University Press, 1995. 273 pp.
Modes of Thought
Authors: Pospisil Leopold
Published: January 2005

Modes of Thought. Wolfgang Fikentscher. Tübingen, Germany: J. C. B. Mohr, 1995. 652 pp.
Lebenslust und Fremdenfurcht: Ethnologie im Dritten Reich
Authors: Messing Simon D.
Published: January 2005

Lebenslust und Fremdenfurcht: Ethnologie im Dritten Reich. Thomas Hauschild. ed. Frankfurt am Main, Germany: Suhrkamp, 1995. 224 pp.
The Russian Concept of Work: Suffering, Drama, and Tradition in Pre‐ and Post‐Revolutionary Russia
Authors: Ries Nancy
Published: January 2005

The Russian Concept of Work: Suffering, Drama, and Tradition in Pre‐ and Post‐Revolutionary Russia. Anna Feldman Leibovich. Westport, CT: Praeger, 1995. 166 pp.
The Health Consequences of Cultural Consonance: Cultural Dimensions of Lifestyle, Social Support, and Arterial Blood Pressure in an African American Community
Authors: Dressler William W. , Bindon James R.
Published: January 2005

Cultural dimensions of health and behavior have been difficult to study because of limited theoretical and methodological models linking the cultural, the individual, and the biological. We employ a cognitive theory of culture to understand culture and health in an African American community in the southern United States. First, cultural consensus analysis is used to test for shared cultural models of lifestyles and social supports within the community. Then, the theoretical and operational construct of "cultural consonance" is used to assess the degree to which individuals behave in a way consistent with cultural models. Findings indicate that cultural consonance in lifestyle and social support combine synergistically in association with blood pressure. These associations of cultural consonance and health are not altered by taking into account a variety of other variables, indicating an independent association of cultural dimensions of behavior with health status. Implications of these results for culture theory are discussed, [culture theory, culture consensus analysis, cultural consonance, African American community, arterial blood pressure]
Between a Rock and a Hard Place: The Power and Powerlessness of Transnational Narratives among Gay Martinican Men
Authors: Murray David A. B.
Published: January 2005

In Martinique, self‐identified gay men often tell each other stories about gay communities in other societies. France and Martinique are central characters in these stories but their presence is largely negative: life in the former is criticized for its economic or racial hardships and life in the latter is criticized for homophobia, hypocrisy, and smallness, creating a frustrating catch‐22 for these men. However, in these narratives Quebec often emerges as an ideal destination of racial and sexual freedom. In this paper, I argue that Quebec is signified as utopic in terms that are antithetical and therefore profoundly connected to impressions of social life in France and Martinique. At the same time, however, I maintain that these narratives also reveal common threads in the African‐pan‐American diasporic experience. Furthermore, these men's experiences of "gay" life in other countries demonstrate their awareness of a "global gay" identity, albeit one that is commercially and ideologically centered in Euro‐American societies, [homosexuality, Martinique, transnationalism, diaspora, race]
Expect a Different Story: Portraying the Contemporary Plateau
Authors: Dobkins Rebecca J.
Published: January 2005

By Hand through Memory. Henry J. Casey Hall of Plateau Indians, The High Desert Museum, Bend, Oregon, permanent installation.

Native Arts of the Columbia Plateau: The Doris Swayze Bounds Collection. Susan E. Harless. ed. Seattle: The University of Washington Press. Published in Association with The High Desert Museum, Bend, Oregon, 1998. 136 pp.
The Georgia and South Carolina Coastal Expeditions of Clarence Bloomfield Moore; The East Florida Expeditions of Clarence Bloomfield Moore
Authors: Scarry John
Published: January 2005

The Georgia and South Carolina Coastal Expeditions of Clarence Bloomfield Moore. Lewis Larson. ed. Tuscaloosa: University of Alabama Press, 1998.312pp.

The East Florida Expeditions of Clarence Bloomfield Moore. Jeffrey M. Mitchem. ed. Tuscaloosa: University of Alabama Press, 1999.376pp.
La Genèse
Authors: Stoller Paul
Published: January 2005

La Genèse. 1999.103 minutes, color. film by Cheick Oumar Sissoko. in Bamana with English subtitles. For more information contact California Newsreel, 149 Ninth Street, No. 420, San Francisco, CA 94103, Tel. (415) 621‐6196.
Inagina: The Last House of Iron
Authors: Baerends Els A.
Published: January 2005

Inagina: The Last House of Iron. 1998. 52 minutes, color. video by Eric Huyesecom and Bernard Augustoni in French and English. For more information contact Documentary Educational Resources, 101 Morse Street, Watertown, MA 02172, Tel. (617) 926‐0491, Fax (617) 926‐9519; http://anthropologie.unige.ch/inagina.
The Ethnography of Contradiction: Studying Post‐Unification Germany
Authors: Fiske‐Rusciano Roberta
Published: January 2005

Crumbling Walls and Tarnished Ideals: An Ethnography of East Germany before and after Unification. Hans Baer. Lanham, MD: University Press of America, 1998 155 pp.

Where the World Ended: Re‐Unification and Identity in the German Borderland. Daphne Berdahl. Berkeley: University of California Press, 1999. 294 pp.
Culture and the Future
Authors: Peacock James
Published: January 2005

Culture:. Problem That Cannot Be Solved. Charles W. Nuckolls. Madison: University of Wisconsin Press, 1998. 301 pp.

Culture as Given, Culture as Choice. Dirk van der Elst with Paul Bohannan. Prospect Heights, IL: Waveland Press Inc., 1999. 236 pp.

Culture: Beacon of the Future. D. Paul Schafer. Westport, CT: Praeger Publishers, 1998. 272 pp.
Archaeology of Prehistoric Native America: An Encyclopedia
Authors: Crothers George M.
Published: January 2005

Archaeology of Prehistoric Native America: An Encyclopedia. Guy Gibbon. ed. New York: Garland Publishing, Inc., 1998.941pp.
The Early Days of Sociolinguistics: Memories and Reflections
Authors: Beeman William O.
Published: January 2005

The Early Days of Sociolinguistics: Memories and Reflections. Christina Bratt Paulston and G. Richard Tucker. eds. Dallas, TX: Summer Institute of Linguistics, 1997. 362 pp.
Clash of Spirits: The History of Power and Sugar Planter Hegemony on a Visayan Island
Authors: Howell Brian
Published: January 2005

Clash of Spirits: The History of Power and Sugar Planter Hegemony on. Visayan Island. Filomeno V. Aguilar Jr. Manila/Honolulu: Ateneo de Manila University Press/University of Hawaii Press, 1998. 313 pp.
Across the Boundaries of Belief: Contemporary Issues in the Anthropology of Religion; Religion and Magic: Approaches and Theories
Authors: Winkelman Michael
Published: January 2005

Across the Boundaries of Belief: Contemporary Issues in the Anthropology of Religion. Morton Klass and Maxine K. Weisgrau. eds. Boulder, CO: Westview Press, 1999. 416 pp.

Religion and Magic: Approaches and Theories. Graham Cunningham. New York: New York University Press, 1999. 126 pp.
History, Power, Ideology: Central Issues in Marxism and Anthropology
Authors: Francisconi Michael
Published: January 2005

History, Power, Ideology: Central Issues in Marxism and Anthropology. Donald L. Donham. Berkeley: University of California Press, 1999. 240 pp.
Missing Persons: A Critique of Personhood in the Social Sciences
Authors: Carrier James G.
Published: January 2005

Missing Persons:. Critique of Personhood in the Social Sciences. Mary Douglas and Steven Ney. Berkeley: University of California Press, 1998. 223 pp.
Keep Your Head to the Sky: Interpreting African American Home Ground
Authors: Phillips Evelyn Newman
Published: January 2005

Keep Your Head to the Sky: Interpreting African American Home Ground. Grey Gundaker. ed., with the assistance of Tynes Cowan. Charlottesville: University Press of Virginia, 1998. 344 pp.
Cooperative Learning in Context: An Educational Innovation in Everyday Classrooms
Authors: New Wiluam
Published: January 2005

Cooperative Learning in Context: An Educational Innovation in Everyday Classrooms. Evelyn Jacob. Albany: State University of New York Press, 1999. 223 pp.
Ritual and Myth in Odawa Revitalization: Reclaiming a Sovereign Place
Authors: Walter Nancy Peterson
Published: January 2005

Ritual and Myth in Odawa Revitalization: Reclaiming. Sovereign Place. Melissa A. Pflüg. with. foreword by Lee Irwin. Norman: University of Oklahoma Press, 1998. 280 pp.
Waorani: The Contexts of Violence and War
Authors: Cook Klmberley
Published: January 2005

Waorani: The Contexts of Violence and War. Clayton Robarchek and Carole Robarchek. Fort Worth, TX: Harcouit Brace College Publishers, 1998. 202 pp.
The Anthropology of Korea: East Asian Perspectives
Authors: Chin Soo‐Young
Published: January 2005

The Anthropology of Korea: East Asian Perspectives. Mutsuhiko Shima and Roger L. Janelli. eds. Osaka: National Museum of Ethnology, 1998. 237 pp.
Farmers of the Golden Bean: Costa Rican Households and the Global Coffee Economy
Authors: Jarvenpa Robert
Published: January 2005

Farmers of the Golden Bean: Costa Rican Households and the Global Coffee Economy. Deborah Sick. Dekalb: Northern Illinois University Press, 1999. 169 pp.
Housewives, Chosen Women, Skilled Men: Cloth Production and Social Identity in the Late Prehispanic Andes
Authors: Costin Cathy Lynne
Published: January 2005

Cloth was the most economically, politically, and rituaUy valuable item in the late prehispanic Andes, and it might be expected that producers, distributors and consumers of this valuable would compete to capture the symbolic significance of these goods as an attribute or identity for themselves. Much has been said of the elite patrons of the textile arts in the Andes; far less has been said of the producers. Cloth production traditionally employed domestic – largely female – labor for both utilitarian and wealth production. The Inka state expanded textile production by taxing conquered households and by developing two new categories of specialist weavers. In reorganizing the economy, the Inka redefined the social identities of cloth producers to ensure that the symbolic significance of cloth accrued to the state, rather than to producers. The traditional category of domestic producers were dissociated from their products, likely seeing their own status diminish as the value of their products increased. The aqUakuna category of female specialist weavers enjoyed an idealized high status commensurate with the value of the exquisite cloth they wove, but at a high personal cost, as they remained sequestered virgins under control of the state.
The Multiple Identities of Aztec Craft Specialists
Authors: Brumfiel Elizabeth M.
Published: January 2005

This paper argues that because Atec specialists worked in a variety of institutional settings and produced a range of goods with different symbolic implications, they shared no single social identity. These factors produced almost a continuous range of variation in the social identities of specialists. For both male and female specialists, the concentration of production was the most important determinant of specialist identity because it determined the ability of specialists to negotiate their own status through collective action and public ritual.
Ritual Craft Specialists in Middle Range Societies
Authors: Spielmann Katherine A.
Published: January 2005

This chapter focuses on the social identity of specialists who produced items used in ritual contexts in prehistoric middle range societies. After introducing two prehistoric case studies (Mimbres and Ohio Hopewell) that illustrate the range of productive scale for ritual crafts, ethnographic case studies (Iroquois and Northwest Coast) are discussed to provide more detail on the social identities of ritual craft specialists. It is concluded that artistic skill, regardless of social status, is the primary criterion for the production of ritual icons in many middle range societies. In contexts in which ritual knowledge is critical in status‐building, however, the ritual practitioners themselves are likely to be the ritual craft specialists.
Identity and Social Action among South Indian Craft Producers of the Vijayanagara Period
Authors: Sinopoli Carla M.
Published: January 2005

Economic, political, demographic, territorial, and social changes in fourteenth through seventeenth century southern India contributed to an expansion in the production and exchange of a range of craft goods. Producers of these goods responded to and benefited from changing conditions in a variety of ways. In this paper I consider archaeological and inscriptional evidence for craft production from the Vijayanagara period, with a focus on how changing demands and valuations of goods differentially affected the ability of craft producing communities to manipulate or redefine their social identity and social status. I focus on three scales of social identity and action: the individual artisan, local caste communities, and multi‐caste or regional artisan groups.
Craft Specialization, Gender, and Personhood among the Postconquest Maya of Yucatan, Mexico
Authors: Clark John E. , Houston Stephen D.
Published: January 2005

The early ethnohistoric sources from Yucatan contain a wealth of information concerning Maya artisans, their craft activities, and the special goods they produced. We examine the principal sources for information on the sexual division of labor, engendered craft activities, and the influence of crafts and related domestic arts on Maya perceptions of self. Lexical data from the dictionary sources demonstrate a clear gender complementarity in the organization of work and craft activities. Detailed observations of native practices by early Spanish clerics further suggest that mastery of the basic domestic arts was critical in Maya self perceptions of full personhood.
Elite Maya Pottery and Artisans as Social Indicators
Authors: Reents‐Budet Dorie
Published: January 2005

Pre‐Columbian Maya Classic period (A.D. 250–850) polychrome pottery underwent a metamorphosis during the sixth century A.D. to become a polyvalent pictorial and hieroglyphic narrative phenomenon whose transformation is tied directly to the period's sociopolitical developments. These specialized ceramics, created for and sometimes by members of the ruling stratum, are important indicators of the social and political dynamics of the Late Classic period (A.D. 550–850). This pictorial pottery informs on the heightened sociopolitical role of specialized crafting and also on that of the artists during this dynamic period. The elevated social identities of some of these artisans, in part created by a perceived connection between them and the gods of Creation, lent prestige to their crafted items. This constructed identity increased the social value of these crafted objects in their role as important accouterments of the sociopolitical power structures of the Late Classic period.
Cultures of Unemployment: A Comparative Look at Long‐Term Unemployment and Urban Poverty
Authors: Wilson Tamar Diana
Published: January 2005

Cultures of Unemployment:. Comparative Look at Long‐Term Unemployment and Urban Poverty. Godfried Engbersen. Kess Schuyt. Jaap Timmer and Frans Van Waarden .1993. Boulder, CO: Westview Press, 277 pages.
Bridging Human and Ecological Landscapes: Participatory Research and Sustainable Development in an Andean Frontier
Authors: Gelles Paul H.
Published: January 2005

Bridging Human and Ecological Landscapes: Participatory Research and Sustainable Development in an Andean Frontier. Robert E. Rhoades. ed. Dubuque, IA: Kendall/Hunt Publishing Company, 2001.
Waiting for Rain: Agriculture and Ecological Imbalance in Cape Verde
Authors: Ferrara Enzo
Published: January 2005

Waiting for Rain: Agriculture and Ecological Imbalance in Cape Verde. Mark Langworthy and Timothy J. Finan. Boulder, CO: Lynne Rlenner Publishers, 1997.
Agrarian Environments: Resources, Representation, and Rule in India
Authors: Hardgrove Anne
Published: January 2005

Agrarian Environments: Resources, Representation, and Rule in India. Arun Agrawal and K. Sivaramakrishnan. eds. Durham, NC: Duke University Press, 2000.
Books Received and Noted
Authors: Schevill Margot Blum
Published: January 2005

Heinbuch. Jean. Quillwork Companion: An Illustrated Guide to Techniques of Porcupine Quill Decoration (1990) Liberty, UT: Eagle's View Publishing Company, 92 pp.,. color plates, 53 black‐and‐white illustrations, tables, figures,. 1/2". 11", ISBN 0‐943604‐25‐7, $9.95 (paper), 0‐943604‐26‐5, $15.95 (hardcover). Eagle's View Publishing company, 6756 North Fork Road, Liberty, UT 84310.

Anton. Ferdinand Ancient Peruvian Textiles (1987) Translated from German by Michael Heron. London: Thames and Hudson, 236 pp., 112 color plates, 189 black‐and‐white and sepia photographs, and drawings, table, map, selected bibliography, index, 12". 9 3/4", ISBN 0‐500‐01402‐7, $40 (hardcover).

Duncan. Kate C. Northern Athapaskan Art:. Beadwork Tradition (1989) Seattle: University of Washington Press, 224 pp., 44 color plates, 186 black‐and‐white illustrations, maps, appendix, bibliography, index, 11 1/2". 9 1/4", ISBN O‐295‐96569‐X, $45 (hardcover). University of Washington Press, PO Box 50096, Seattle, Washington 98145‐5096.

LeCount. Cynthia Gravelle Andean Folk Knitting: Traditions and Techniques from Peru and Bolivia (1990) Saint Paul: Dos Tejedorat Fiber Arts Publications, 146 pp., 46 color plates, 120 black‐and‐white photographs, 100 drawings, graphs, maps, glossary, bibliography, index, 11". 8 1/2", ISBN 0‐932394‐ 07‐8, $20 (paper), plus $2.50 postage. Dos Tejedoras, 757 Raymond Ave., Saint Paul, MN 55114.

Gibson‐Roberts. Priscilla Salish Indian Sweaters (1989) Saint Paul: Dot Tejedorai Fiber Arts Publications, 120 pp., 120 charts, 50 line drawings, 62 blackand‐ white photographs, 11". 8 1/2", ISBN 0‐ 032394‐13‐2, $17.50 (paper), plus $2.50 postage. Dos Tejedoras Fiber Arts Publications, 757 Raymond Ave., Saint Paul, MN 55114.
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain
Authors: Cobos Inma , Broccoli Vania , Rubenstein John L.R.
Published: January 2005

The Dlx transcription factors have a central role in controlling the development of γ‐aminobutyric acid (GABA)‐ergic neurons in the forebrain. However, little is known about how they control the properties of GABAergic neurons. One candidate is the Aristaless (Arx) homeobox gene, which lies genetically downstream of the fly Dlx gene (Distal‐less, Dll). The expression of Arx in the mouse forebrain includes Dlx‐expressing territories, such us the ventral thalamus, parts of the hypothalamus, and the ganglionic eminences and their derivatives in the subpallial telencephalon, and is expressed, as with the Dlx genes, in cortical GABAergic neurons. By using gain‐of‐function and loss‐of‐function assays in mouse and chicken embryos, we show that the Dlx genes have a conserved role in regulating the expression of Arx in the forebrain of vertebrates. Ectopic expression of Dlx genes with electroporation in brain slices from mouse embryos and in the neural tube of chick embryos shows that Dlx genes are sufficient to induce Arx ectopically. Moreover, we provide evidence that the Dlx genes exert a functionally relevant role in regulating Arx in vivo, as shown by the severe reduction in the expression of Arx in Dlx1/2 double‐knockout mice. Therefore, our results suggest evolutionarily conserved functions of Dlx genes in regulating Arx expression between Drosophila and vertebrates. J. Comp. Neurol. 483:292–303, 2005. © 2005 Wiley‐Liss, Inc.
Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
Authors: Yu Tun‐Tzu , McIntyre Jeremy C. , Bose Soma C. , Hardin Debra , Owen Michael C. , McClintock Timothy S.
Published: January 2005

In comparing purified mouse olfactory sensory neurons (OSNs) with neighboring cells, we identified 54 differentially expressed transcripts. One‐third of the transcripts encode proteins with no known function, but the others have functions that correlate with challenges faced by OSNs. The OSNs expressed a diversity of signaling protein genes, including stomatin (Epb7.2), S100A5, Ddit3, Sirt2, CD81, Sdc2, Omp, and Ptpla. The elaboration of dendrites, cilia, and axons that places OSNs in contact with diverse cell types and signals presumably also requires large investments in cytoskeletal‐associated proteins, lipid biosynthesis, and energy production. Several of the genes encode proteins that participate in these biological processes, including ATP5g3, Ndufa9, Sqrdl, Mdh1, Got1, β‐2 tubulin, Capza1, Bin3, Tom1, Acl6, and similar to O‐MACS. Three transcripts had restricted expression patterns. Similar to O‐MACS and Gstm2 had zonally restricted expression patterns in OSNs and sustentacular cells but not in Bowman's glands, suggesting that zonality can be differentially regulated by cell type. The mosaic expression pattern of S100A5 in approximately 70% of OSNs predicts that it is coexpressed with a subset of odorant receptors. We captured four abundant transcripts, Cyp2a4, similar to Cyp2g1, Gstm2, and Cbr2, that encode xenobiotic metabolizing enzymes expressed by sustentacular cells or Bowman's glands, reinforcing the interpretation that clearance of xenobiotic compounds is a major function of these cells. Within the olfactory epithelium, Cbr2 is a new anatomical marker for sustentacular cells. We also discovered that Reg3g is a marker for respiratory epithelium. J. Comp. Neurol. 483:251–262, 2005. © 2005 Wiley‐Liss, Inc.
Developmental changes in spinal motoneuron dendrites in neonatal mice
Authors: Li Yan , Brewer Diana , Burke Robert E. , Ascoli Giorgio A.
Published: January 2005

We examined the age‐dependent morphological changes of lumbar spinal motoneurons (MNs) in neonatal Swiss‐Webster mice during the first 2 weeks of postnatal life. Neurons labeled by intracellular injection of biocytin in hemisected lumbosacral spinal cords in vitro were reconstructed from serial sections. Digitized data were compared for young (P3; postnatal days 2–4; n = 9) and older animals (P11; postnatal days 10–13; n = 8). As expected, measures of dendritic size (e.g., stem branch diameter, total surface area, maximum distance to tips, and lateral tree spread) were all significantly greater for P11 than for P3 mice. In contrast, the number of dendrites per MN and parameters related to tree topology (e.g., terminations per tree and maximum branch order), although slightly greater for P11 animals, were not significantly different between the two ages. Dendrite growth appeared to be proportional throughout the tree because the ratios between average terminal and internal branch lengths were similar for the two groups. Furthermore, this elongation was proportional to enlargement of overall spinal cord dimensions. A variety of other morphometric measures showed no significant difference between age groups. The relative constancy of MN dendritic topology up to P13 was surprising, given the striking maturation in motor function during this time period. J. Comp. Neurol. 483:304–317, 2005. Published 2005 Wiley‐Liss, Inc.
Tetraspanin‐5 (Tm4sf9) mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En‐2 transgenic mice
Authors: Juenger C. Hendrik , Holst Martin I. , Duffe Katja , Jankowski Jakob , Baader Stephan L.
Published: January 2005

Tetraspanin‐5 (Tspan‐5) mRNA was recently shown to be strongly expressed within the central nervous system. In order to address Tspan‐5 function during nervous system development, we performed a detailed expression analysis in the postnatal FVB/N mouse cerebellum using in situ hybridizations. Tspan‐5 mRNA was expressed within cerebellar Purkinje cells (PCs) throughout postnatal development. The expression level, however, changed significantly with ongoing development. At the day of birth (P0), Tspan‐5 mRNA was expressed at very low levels in PCs. At this time, PCs of the FVB/N strain are postmitotic and bear axons, but no dendrites. At P7, Tspan‐5 mRNA expression was visible in all PCs, but was more prominent in those of the posterior lobules as compared to those of the anterior lobules. After P7, high levels of Tspan‐5 mRNA were seen in all PCs, which is when PCs elaborate and maintain their typical dendritic tree. This demonstrates that the level of Tspan‐5 mRNA is related to the developmental status of PCs. Consistently, expression of Tspan‐5 mRNA was specifically reduced in PCs of L7En‐2 animals, which display a delay in PC maturation during postnatal cerebellar development. In addition, whereas no Tspan‐5 mRNA signal could be detected in the proliferating granule cell layer, low levels could be found in postmitotic, premigratory granule cells and high levels in settled and differentiated granule cells. Thus, the level of Tspan‐5 mRNA expression correlates very well with the differentiation status of particular neurons. The level of Tspan‐5 expression might therefore be important for distinct phases of neuronal maturation. J. Comp. Neurol. 483:318–328, 2005. © 2005 Wiley‐Liss, Inc.