bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da atividade antioxidante e antibacteriana do extrato da flor de Hibiscus sabdariffa e Hibiscus rosa-sinensis
Authors: Silva Nathalia Lucca , Viana Fernanda Campos , Alves Laila Francielli , Santos Esther Camila Silva , De Andrade Lorrana Rodrigues , Morais Melissa Grazielle , Dos Santos Alan Cristian , Amaro Sergio Henrique
Published: April 2019

Introdução: O Hibiscus rosa-sinensis pertence à família Malvaceae, é utilizada na medicina popular para aliviar cólicas menstruais, auxiliar no parto, aliviar dor de cabeça, febre, inflamação, problemas respiratórios, infecções cutâneas, distúrbios digestivos entre outros. O Hibiscus sabdariffa também pertence à família Malvaceae, na medicina popular é utilizado como diurético, tratamento gastrointestinal, infecções hepáticas, febre e hipertensão. Objetivo: Avaliar a capacidade antioxidante pelo método de redução do radical livre DPPH, a Concentração Inibitória Mínima (CIM) e a Concentração Bactericída Mínima (CBM). Metodologia: Para a avaliação da capacidade antioxidante foi utilizado o método de sequestro de radicais livres DPPH (2,2­ Difenil-­1­-picrilhidrazila), em espectrofotômetro. Para análise da atividade antimicrobiana, foi utilizado quatro Bactérias da Coleção de Cultura do tipo Americana, Escherichia coli, Staphylococcus aureus, Listeria monocytogenes e Streptococcus agalactiae. Resultados: O H. rosa-sinensis apresentou uma CE50 = 10,33 µg /mL, enquanto o H. sabdariffa apresentou CE50= 20,38 µg /mL. O H. rosa-sinensis possui uma maior capacidade sequestradora de radicais livres. No estudo da atividade antibacteriana a espécie H. sabdariffa apresentou CBM de 1000 µg/mL frente a L. monocytogenes e superior a 2000 µg/mL frente as outras espécies de bactérias avaliadas, enquanto a espécie de H. rosa-sinensis apresentou CBM superior a 2000 µg/mL para todas as espécies avaliadas. Conclusão: O extrato metanólico de H. sabdariffa e H. rosa-sinensis apresentaram capacidade de sequestrar radicais livres,sendo superiores em algumas concentrações ao padrão BHT. Além disso as espécies avaliadas apresentam potencial ação antibacteriana especialmente frente a L. monocytogenes.
Moradia, educação e desenvolvimento para os moradores de ocupações urbanas
Authors: Campolina Pedro
Published: April 2019

Introdução: Este artigo problematiza a história de dificuldades da classe trabalhadora brasileira em ter acesso com dignidade à moradia e educação. Em especial, apresenta a situação atual das ocupações urbanas e dos seus moradores em relação a estes direitos. Objetivo: O objetivo é questionar se estas dificuldades foram constituídas e podem ser solucionadas pela construção de um projeto de desenvolvimento e educação para a sociedade em geral, e as ocupações urbanas em particular. Metodologia: Para tanto, a metodologia deste trabalho consistiu em uma revisão de literatura sobre o tema, por meio de consultas em livros, dissertações, artigos e outras produções científicas. Resultados: O resultado encontrado foi que os projetos hegemônicos de desenvolvimento, habitação e educação implementados ontem e hoje não atenderam e nem atendem a classe trabalhadora brasileira, entre ela, os moradores de ocupações urbanas, e sim, contemplam os interesses da classe dominante. Conclusão: Faz-se necessário, a reflexão, construção e aplicação de teorias e projetos contra-hegemônicos e populares de desenvolvimento e educação que atendam as ocupações urbanas e os seus moradores, e a sociedade brasileira no geral.
Palavras-chave: Educação; Ocupação urbana; Desenvolvimento local.
Score-based Fusion Schemes for Plant Identification from Multi-organ Images
Authors: Nhan Nguyen Thi Thanh , Binh Do Thanh , Hoang Nguyen Huy , Hai Vu , Hai Tran Thi Thanh , Lan Le Thi
Published: April 2019

This paper describes some fusion techniques for achieving high accuracy species identification from images of different plant organs. Given a series of different image organs such as branch, entire, flower, or leaf, we firstly extract confidence scores for each single organ using a deep convolutional neural network. Then, various late fusion approaches including conventional transformation-based approaches (sum rule, max rule, product rule), a classification-based approach (support vector machine), and our proposed hybrid fusion model are deployed to determine the identity of the plant of interest. For single organ identification, two schemes are proposed. The first scheme uses one Convolutional neural network (CNN) for each organ while the second one trains one CNN for all organs. Two famous CNNs (AlexNet and Resnet) are chosen in this paper. We evaluate the performances of the proposed method in a large number of images of 50 species which are collected from two primary resources: PlantCLEF 2015 dataset and Internet resources. The experiment exhibits the dominant results of the fusion techniques compared with those of individual organs. At rank-1, the highest species identification accuracy of a single organ is 75.6% for flower images, whereas by applying fusion technique for leaf and flower, the accuracy reaches to 92.6%. We also compare the fusion strategies with the multi-column deep convolutional neural networks (MCDCNN) [1]. The proposed hybrid fusion scheme outperforms MCDCNN in all combinations. It obtains from + 3.0% to + 13.8% improvement in rank-1 over MCDCNN method. The evaluation datasets as well as the source codes are publicly available.

Keywords: Plant identification, Convolutional neural network, Deep learning, Fusion.
Learning and transferring motion style using Sparse PCA
Authors: Do Khac Phong , Xuan Thanh Nguyen , Yu Hongchuan
Published: April 2019

Motion style transfer is a primary problem in computer animation, allowing us to convert the motion of an actor to that of another one. Myriads approaches have been developed to perform this task, however, the majority of them are data-driven, which require a large dataset and a time-consuming period for training a model in order to achieve good results. In contrast, we propose a novel method applied successfully for this task in a small dataset. This exploits Sparse PCA to decompose original motions into smaller components which are learned with particular constraints. The synthesized results are highly precise and smooth motions with its emotion as shown in our experiments.
Abbreviation Detection in Vietnamese Clinical Texts
Authors: Vo Chau , Cao Tru , Ho Bao
Published: April 2019

Abbreviations have been widely used in clinical notes because generating clinical notes often takes place under high pressure with lack of writing time and medical record simplification. Those abbreviations limit the clarity and understanding of the records and greatly affect all the computer-based data processing tasks. In this paper, we propose a solution to the abbreviation identification task on clinical notes in a practical context where a few clinical notes have been labeled while so many clinical notes need to be labeled. Our solution is defined with a semi-supervised learning approach that uses level-wise feature engineering to construct an abbreviation identifier, from using a small set of labeled clinical texts and exploiting a larger set of unlabeled clinical texts. A semi-supervised learning algorithm, Semi-RF, and its advanced adaptive version, Weighted Semi-RF, are proposed in the self-training framework using random forest models and Tri-training. Weighted Semi-RF is different from Semi-RF as equipped with a new weighting scheme via adaptation on the current labeled data set. The proposed semi-supervised learning algorithms are practical with parameter-free settings to build an effective abbreviation identifier for identifying abbreviations automatically in clinical texts. Their effectiveness is confirmed with the better Precision and F-measure values from various experiments on real Vietnamese clinical notes. Compared to the existing solutions, our solution is novel for automatic abbreviation identification in clinical notes. Its results can lay the basis for determining the full form of each correctly identified abbreviation and then enhance the readability of the records.

Keywords: Electronic medical record, Clinical note, Abbreviation identification, Semi-supervised learning, 

Self-training, Random forest.
Percutaneous Sacroplasty for Sacral Insufficiency Fractures: Case Series and Review of Presentation, Diagnosis, and Treatment
Authors: Clark Andrew C. , Butani Devang
Published: April 2019

Sacral insufficiency fractures (SIFs) are a cause of debilitating low back pain that is often difficult to diagnosis and manage. The diagnosis of SIF is often delayed due to inaccurately attributing symptoms to spondylosis, which is a commonly present in the elderly population where SIFs are most prevalent. Historically, treatment consisted of medical management and open reduction internal fixation reserved for severe cases. However, percutaneous sacroplasty has emerged as a minimally invasive treatment option which provides early pain relief without significant complications. The objective of this article is to raise awareness of SIFs and percutaneous sacroplasty as an effective and safe treatment method.
Polymer Supported Carbon for Safe and Effective Remediation of PFAS-Contaminated Water
Authors: Lundquist Nicholas , Sweetman Martin , Scroggie Kymberley , Worthington Max , Esdaile Louisa , Alboaiji Salah , Plush Sally , Hayball John , Chalker Justin
Published: April 2019

Powdered activated carbon (PAC) is an economical sorbent for removing micropollutants from water, but it generates hazardous dust that is flammable and a respiration hazard. Additionally, the fine particles of PAC can cake and block filters and membranes, complicating its use in continuous processes. In this study, we present a sulfur polymer support for PAC that overcomes these problems. The blend of the sulfur polymer and PAC generates low dust and it does not block filters. The utility of the sorbent is demonstrated in the remediation of water contaminated with perfluorinated alkyl substances (PFASs)—persistent micropollutants that currently threaten water safety worldwide. Fundamental discoveries of PFAS self-assembly are reported, as well as testing on field samples.
Enlarging the Application of the Food Security Index at European Union Regions
Authors: Mihoreanu Larisa , Cismas Laura Mariana , Danila Jianu Laura Maria
Published: April 2019

The food security remains a major priority and a typical issue that requires immediate international solutions. Recent studies reveal the increasing complexity of food security issues focusing on the necessity to address formal actions and solve the dramatic situations. New tools are always welcome to facilitate solutions’ implementation.In September 2015, the United Nations Assembly adopted the 2030 Agenda of Sustainable Development among the goals of which the followings are fundamental: no poverty, zero hunger, good health and well-being, clean water and climate action. The European Union joined the Program, expressing the full commitment to its implementation. According to the Food and Agriculture Organization (FAO), the number of undernourished people reached in 2017 about 821 million peoples, representing an increase from about 804 million peoples in 2016. The 2018 statistics of FAO state that 22% of children under-five are affected by malnutrition, while over 38 million children in the same age group are overweight.Beyond the premises, as a novelty, we contribute at the food security knowledge by calculating a regional index at European and Romanian levels to better outline the realities and provide the decision-makers with a new tool to find better solutions.
DEVELOPMENT OF LEARNING MATERIALS ON CREATIVE MEDIA LEARNING TO SUPPORT ECOPRENEURSHIP IN CHEMISTRY DEPARTMENT FMIPA UNESA
Authors: Novita Dian , Muchlis Muchlis , Tjahjani Siti
Published: April 2019

Learning materials have been developed which then conducted the study and validation to the expert lecturers and then tested to the students to find out the validity of the feasibility of learning materials in the field of Industrial Chemistry as one of the supporting subjects of Ecopreneurship in Chemistry Department. From the data obtained can be concluded that learning materials in the form of Lesson Plan, Worksheet, and Instrument Rating get very good criteria. These criteria are obtained based on theoretical feasibility and empirical feasibility. Based on these results, learning tools developed can be used as learning tools for Industrial Chemistry courses to support ecopreneurship.
Media Pembelajaran Pengenalan Hewan Untuk Siswa Sekolah Dasar Menggunakan Augmented Reality Berbasis Android
Authors: Irfansyah Juki
Published: April 2019

Kurikulum 2013 adalah kurikulum berbasis kompetensi yang dirancang untuk mengantisipasi kebutuhan kompetensi Abad 21. Pada abad ini, kemampuan kreativitas dan komunikasi akan menjadi sangat penting. Sejalan dengan itu, rumusan kompetensi sikap, pengetahuan, dan keterampilan yang dipergunakan dalam Kurikulum 2013 mengedepankan pentingnya kreativitas dan komunikasi. Metode pembelajaran yang digunakan untuk kurikulum 2013 pada tingkat SD berikut menggunakan pendekatan pembelajaran tematik. Dimana guru dituntut untuk memberikan materi pembelajaran dengan cara yang kreatif dan inovatif maka dari itu salah satu alternatifnya berupa sebuah media pembelajaran interaktif. Media pembelajaran dalam hal ini memakai fitur yang terbilang masih baru yaitu fitur Augmented Reality dimana fitur ini memadukan antara objek nyata dengan objek maya. Media pembelajaran ini dibuat dengan menggunakan software Unity3D dengan memasukan unsur objek 3D yang dibuat dengan menggunakan software Blender/Lightwave 3D sebagai peraga. Materi pembelajaran diambil dari buku panduan Kelas 1 SD Kurikulum 2013 mengenai Hewan di Sekitarku. Hasil dari pengujian aplikasi Pengenalan Hewan dapat berjalan pada berbagai perangkat mobile Android. Berdasarkan hasil data pengujian dapat disimpulkan bahwa aplikasi ini dapat membantu meningkatkan minat dan pemahaman siswa dalam belajar.
El concepto de cultura como clave para el análisis de la relación entre las subjetividades e instituciones en G. Deleuze
Authors: Gulino Pablo Martín
Published: April 2019

El presente trabajo pretende señalar al concepto de cultura expresado en la obra Nietzsche y la filosofía de G. Deleuze, como una clave para comprender la producción de subjetividades e instituciones así como la relación entre ambas. De este modo, pretendemos señalar a la cultura como el elemento que nos muestra la compleja trama de fenómenos en la que se ve envuelta la producción de sujetos e instituciones. Así también, y en relación con esta complejidad, se inscribe una manera no causal de comprender la relación entre las instituciones y los sujetos. De esta forma, entendemos que la cultura puede ser entendida como el concepto que nos permite observar la complejidad que esconde la producción de sujetos e instituciones así como su relación no lineal entre estas.

 
El biopoder patriarcapitalista y la destrucción de la masculinidad. La resistencia en clave femenina y feminista
Authors: Bordón Gabriele Camila V.
Published: April 2019

El feminismo permite nuevas formas de interpretar la propuesta foucaultiana sobre la biopolítica. El biopoder se emplaza en una estructura patriarcapitalista, heredera del Estado moderno, donde sus mecanismos de control de la población se vuelven claves en el cuerpo percibido femenino o cuerpa, término apropiado por el feminismo contemporáneo. El entramado de luchas no es solo en política, en términos de esfera pública, sino que la vista se vuelve sobre el espacio doméstico, lugar que históricamente se asocia y se restringe a la feminidad. En él hay cuatro mecanismos representativos: el sexo falocéntrico, el aborto, el parto y el feminicidio. Estos mecanismos disponen fuerzas productivas en el trabajo, en una lógica binaria, jerárquica y sexual. Operan como estrategias dos figuras, tomadas de la antropóloga Rita Segato, el varón moralizador y la mujer sospechosa. El análisis del juego poder-resistencia permite el encuentro de puntos de fuga. El espacio de lucha es principalmente el lugar doméstico, lo privado o lo íntimo, lo otro binario en relación al Estado y al interés público. La resistencia es al saber normalizador de las prácticas de lo cotidiano, que significa normalizar sobre los cuerpos y la vida principalmente de mujeres e identidades que se perciban femeninas.

 
When doing good pays : A first research into the remuneration practices of non-profit executives (particularly the IT sector).
Authors: Akmut Camille
Published: April 2019

Research into the compensation of executives of non-profit organizations (with particular attention paid to the technology sector). Collected data is presented in original form, with some analysis of the differentiated remuneration strategies.
Good on paper: sociological critique, pragmatism, and secularization theory
Authors: Dromi Shai M. , Stabler Samuel D.
Published: April 2019

Recent years have seen numerous sociological disagreements devolve into heated debates, with scholars openly accusing their peers of being both empirically wrong and morally misguided. While social scientists routinely reflect on the ethical implications of certain research assumptions and data collection methods, the sociology of knowledge production has said little about how moral debates over scholarship shape subsequent research trajectories. Drawing on the new French pragmatic sociology, this article examines how sociologists respond to criticisms of the moral worth of their research. The article outlines three typical responses: (1) accepting the criticism and changing direction completely; (2) accepting the criticism but changing discursive framing to incorporate existing research without being subject to critique; and (3) navigating through the debate by devising new research directions that do not trigger such criticism. To demonstrate, the article looks at how sociologists of religion responded, in their published scholarship, to criticisms of secularization theory as depreciating religious people and spiritual experience. Across the responses, we show that sociologists have included moral considerations in their empirical investigations, and have switched among several diverse moral justifications to address—and also avoid—criticism. We conclude by demonstrating that this model can be extended to other domains of sociological inquiry, including the study of gender-based wage inequality and methodological nationalism. The article highlights the importance of mapping the moral frameworks sociologists use for the sociology of knowledge and the sociology of morality.
Evaluation of User Behavior and Acceptance of an On-Bike System
Authors: Prati Gabriele , Puchades Víctor Marín , De Angelis Marco , Pietrantoni Luca , Fraboni Federico , Decarli Nicolò , Guerra Anna , Dardari Davide
Published: April 2019

In this study, users’ acceptance of an on-bike system that warns about potential collisions with motorized vehicles as well as its influence on cyclists’ behavior was evaluated. Twenty-five participants took part in a field study that consisted of three different experimental tasks. All participants also completed a follow-up questionnaire at the completion of the three-task series to elicit information about the acceptance of the on-bike system. In the experiment phase, participants were asked to ride the bicycle throughout a circuit and to interact with a car at an intersection. Participants completed three laps of the circuit. The first lap involved no interaction with the car and served the purpose of habituation. In the second and third laps participants experienced a conflict with an incoming car at an intersection. In the second lap, the on-bike device was not activated, while in the third lap, participants received a warning message signaling the imminent conflict with the car. We compared the difference in user’s behavior between the second lap (conflict with a car without the warning of the on-bike system) and the third lap (conflict with a car with the warning of the on-bike system). Results showed that, when entering the crossroad, participants were more likely to decrease their speed in case of warning of the on-bike system. Further, the on-bike system was relatively well accepted by the participants. In particular, participants did not report negative emotions when using the system, while they trusted it and believed that using such technology would be free from effort. Participants were willing to spend on average 57.83€ for the system. This study highlights the potential of the on-bike system for promoting bicycle safety.
Agent-Based Models for Assessing Complex Statistical Models: An Example Evaluating Selection and Social Influence Estimates from SIENA
Authors: Daza Sebastian , Kreuger L. Kurt
Published: April 2019

Although Agent-based models (ABM) have been increasingly accepted in social sciences as a valid tool to formalize theory, propose mechanisms able to recreate regularities, and guide empirical research, we are not aware of any research using ABMs to assess the robustness of our statistical methods. We argue that ABMs can be extremely helpful to assess models when the phenomena under study is complex. As an example, we create an ABM to evaluate the estimation of selection and influence effects by SIENA, a stochastic actor-oriented model proposed by Tom A. B. Snijders and colleagues. It is a prominent network analysis method that has gained popularity during the last 10 years and been applied to estimate selection and influence for a broad range of behaviors and traits such as substance use, delinquency, violence, health, and educational attainment. However, we know little about the conditions for which this method is reliable or the particular biases it might have. The results from our analysis show that selection and influence are estimated by SIENA asymmetrically, and that with very simple assumptions, we can generate data where selection estimates are highly sensitive to mis-specification, suggesting caution when interpreting SIENA analyses.
A Critique of the Adverse Childhood Experiences Framework in Epidemiology and Public Health: Uses and Misuses
Authors: Kelly-Irving Michelle , Delpierre Cyrille
Published: April 2019

Adverse childhood experiences (ACEs) have emerged as a major research theme. They make reference to an array of potentially harmful exposures occurring from birth to eighteen years of age and may be involved in the construction of health inequalities over the lifecourse. As with many simplified concepts, ACEs present limitations. They include diverse types of exposures, are often considered cumulatively, can be identified using prospective and retrospective approaches, and their multidimensional nature may lead to greater measurement error. From a public health perspective, ACEs are useful for describing the need to act upon complex social environments to prevent health inequalities at a population level. As the ACEs concept becomes popular in the context of policy interventions, concerns have emerged. As a probabilistic and population-level tool, it is not adapted to diagnose individual-level vulnerabilities, an approach which could ultimately exacerbate inequalities. Here, we present a critique of the ACEs framework, discussing its strengths and limits.
Epstein-Barr Virus (EBV) infection related thrombocytosis : A Case Report
Authors: Adhikari Suman , Malla Rewati Raman , Shah Manoj , Upreti Ananta , Thapa Bhawesh
Published: April 2019

EBV infection can occur worldwide. We managed a 17 year old male who developed transient pancytopenia followed by thrombocytosis concurrent with EBV infection. To the best of our knowledge we have not encountered any cases of thrombocytosis concurrent with EBV infection before. Our case was diagnosed as a case of EBV infection with the help of serology and managed conservatively. In our case, though it is uncommon to find thrombocytosis due to EBV infection, it is possible that following pancytopenia concurrent with the EBV infection, the patient might have developed secondary or reactive thrombocytosis due to elevated endogenous levels of thrombopoietin, interleukin-6, catecholamines.
रातो आकाश उपन्यास जनयुद्धजन्य यथार्थको उदात्तीकरण Rato Aakash Upanyas Janayuddhajanya Yatharthako Udattikaran
Authors: शर्मा Sharma अमृता Amrita देवी Devi
Published: April 2019

Not available.

उपलब्ध छैन ।
Comparative Analysis of Memristor based Synaptic Circuits for Neuromorphic Architectures
Authors: Budhathoki Ram Kaji
Published: April 2019

Memristor is one of the fundamental electrical elements, which has recently been successfully built. Memristor is being used extensively as synapses in neuromorphic applications. A common method for developing memristor based synaptic circuits is to store synaptic weight values within memristors as resistance values. It requires use of the continuous resistance (memristance) range available in the memristors to store the weights. In this paper, we study how different compact synaptic circuits implemented using Ti02 memristors to perform zero, negative, and positive synaptic weightings. Results of different memristor based circuits, based on pulsed input signals, are compared, analyzed and presented using Ti02 memristors via simulations.
Prospect of Floor Heating System in Residential Buildings in Kathmandu Using Compound Parabolic Concentrator (CPC)
Authors: Khanal Ramesh
Published: April 2019

Underfloor heating system is more suitable for space heating because of its unique temperature gradient profile. If solar radiation can be utilized for heating of water in radiant floor heating system, the cost of electricity can be reduced. Because of the sufficient availability of solar radiation in Kathmandu Valley during winter season, underfloor heating with solar water heating can be a viable technology for residential buildings. So this paper is focused on identifying suitable system/or domestic radiant floor heating system. Compound parabolic concentrator (CPC) water heating system is more suitable for heating water because tracking system is not required and sufficient water temperature can be achieved. It is also found that more studies are necessary to make the system cost effective and suitable for the residential buildings in Kathmandu.
PENERAPAN METODE AHP UNTUK MENENTUKAN KUALITAS PAKAIAN JADI DI INDUSTRI GARMENT
Authors: Rachman Rizal
Published: April 2019

Dalam era globalisasi, persaingan bisnis menjadi sangat tajam, baik dipasar nasional maupun di pasar internasional. Meningkatnya intensitas persaingan dan jumlah pesaing juga menuntut setiap perusahaan untuk selalu memperhatikan kebutuhan dan keinginan konsumen serta berusaha memenuhi apa yang mereka harapkan dengan cara yang lebih memuaskan dari pada yang dilakukan para pesaing. Kualitas merupakan faktor terpenting untuk menghasilkan standart mutu dalam mengambil keputusan. Selama ini di perusahaan hanya mengandalkan perhitungan manual untuk sistem penunjang keputusan. Biasanya penilaian terhadap kualitas suatu jenis pakaian biasanya bergantung pada jenis bahannya. Padahal bukan hanya bahan pakaian saja yang bisa menjadi acuan kualitas. Berbagai hal detail lainnya juga patut menjadi perhatian, misalnya bagian jahitan. Maka dari itu peneliti akan membuat perhitungan dengan menggunakan metode AHP (Analytic Hierarchi Process) dengan mendefinisikan masalah, pembuatan struktur hierarki serta menentukan kriteria-kriteria dan alternatif-alternatif pilihan. Selanjutnya menghitung nilai Eigen Vector dan menguji konsistensinya. Hasil penelitian menunjukkan sistem penunjang keputusan yang digunakan untuk menentukan kualitas pakaian jadi sudah dapat melakukan perhitungan dengan metode AHP lebih cepat dibandingkan perhitungan secara manual sehingga bisa lebih efesien dan tingkat keakuratan data
Analisis Sentimen Review Restoran menggunakan Algoritma Naive Bayes berbasis Particle Swarm Optimization
Authors: Sari Retno
Published: April 2019

Terdapatnya aplikasi yang memudahkan untuk mengetahui ulasan dari suatu tempat atau makanan membuat pembaca dengan mudah menentukan tempat untuk mereka berwisata kuliner. Ulasan yang diberikan terdiri dari ulasan positif dan ulasan negatif. Algoritma Naive Bayes berbasis Particle Swarm optimization dilakukan untuk mengetahui apakah terdapat peningkatan akurasi. Dataset yang digunakan berupa review restoran yang dibagi menjadi 2 class yaitu class positif dan class negatif, data diujikan menggunakan 10 Fold Cross Validation. Analisis sentimen review restoran menggunakan Algoritma Naive Bayes berbasis Particle Swarm Optimization menghasilkan akurasi sebesar 82.45%. Hasil ini lebih baik dibandingkan dengan menggunakan algoritma Naive Bayes saja yang menghasilkan akurasi sebesar 74.34%.
ВОЗМОЖНОСТИ МЕДИАЦИИ В КОЛЛЕДЖЕ
Authors: Ivanova E. N. , Dobryakova M. G. , Loginova I. E.
Published: April 2019

The article is devoted to the urgent problem of conflict in educational departments. Possibilities of different types of mediation implementation in the system of secondary specialized education are discussed on the example of successful experience of mediators’ practice in the one of Petersburg colleges. The presence of enough legal and administrative bases for mediation application in the system of secondary specialized education is shown. Practical absence of such activities compare with the similar work on mediation implementation in schools was noticed. There were several most widely spread conflict types in the college and their similarity with school problems are identified. Specific features of conflicting parties in college and connected with them complication were appointed. On the particular cases examples the technology of problem management are shown, the factors and dynamics of the situations development are analyzed and the results of mediator’s professional penetration are displayed. The accent on need of neutral objective approach of conflict resolution specialists to conflict participants and significance of the college administration readiness to not formal participation in the process of mediation implementation is made. The hardness of taking responsibility for the investment to conflict arising and escalation by the parties, especially the adult ones, is identified. Here is the need and possibility to help conflictants to get aware of the idea that conflict is a result of actions from both sides. The prolonged influence of mediations conducting and their positive aside effects are shown. The plans of future mediation development in college are presented and recommendations for spreading these practices in the system of secondary specialized education is made.
New Steel Grades for Deep Carburizing of Windmill Transmission Components*
Authors: Catteau S. , Sourmail T. , Elvira R. , Ziegler C. , Fayek P. , Prahl U. , Staudt J. , Solf M. , Woehrle T.
Published: April 2019

However, while low pressure carburizing (LPC) is now well established for smaller components and conventional conditions (up to 980 °C), a number of difficulties are expected when considering high temperature LPC of large components. First, conventional carburizing steels will undergo extensive grain growth during an exposure to 1050 °C for 20 hours; while there are solutions to avoid the problem for shorter durations, there are no materials adapted to such heat-treatment durations. Second, the long exposure at high temperature means that the possibility of significant creep deformation should be considered. And third, the hardenability of the material commonly used for wind turbine gears (18CrNiMo7-6) may not be sufficient when switching from oil to gas quenching. The present work attempts to address these issues. On the basis of theoretical alloy design, numerical modeling and experimental work, two purposely designed steel compositions were industrially cast. They were used to manufacture large wind turbine gears and extensively tested. Experimental results are compared to those obtained with a standard 18CrNiMo7-6. Based on a full analysis of the possible production routes, a cost benefit of 20 % is estimated by switching from the actual to the newly developed manufacturing route.
Simulation-Aided Process Chain Design for the Manufacturing of Hybrid Shafts
Authors: Behrens B.-A. , Breidenstein B. , Duran D. , Herbst S. , Lachmayer R. , Löhnert S. , Matthias T. , Mozgova I. , Nürnberger F. , Prasanthan V. , Siqueira R. , Töller F. , Wriggers P.
Published: April 2019

Researchers of the Collaborative Research Centre CRC 1153 are investigating novel process chains to manufacture function-adapted and lightweight machine components. In each step of the process chain, numerical simulation tools are utilised in the process design to take into account locally specific material behaviour under particular processing conditions. In this paper, solution approaches associated with the modelling of manufacturing processes are presented.
RISKS IN FORMATION OF BUDGET RELATIONS IN DECENTRALIZATION CONDITIONS AND PROBLEMS OF REFORM OF THE PENSION SYSTEM IN UKRAINE
Authors: Vasylchak S. V. , Dubyna Mariya Petrivna M. P. , Soloviy S. B. , Zhydyak O. R.
Published: April 2019

The subject of the study is theoretical and methodological principles of theformation of inter-budgetary relations in Ukraine in the conditions of decentralization andreformation of the pension system.The purpose of the study is to identify the most significant problems of the development ofthe pension system in Ukraine in the context of developing intergovernmental fiscal relations ina context of decentralization and outlining possible solutions.

Research methods. The study uses a set of scientific methods and approaches, includinglogical generalization, systemic, comparison method, graphical, which allowed to ensure theconceptual unity of the research .Results of work. The article investigates the state of inter-budgetary relations of Ukraine inthe conditions of decentralization. A comparative characteristic of centralized and decentralizedmodels of intergovernmental fiscal relations has been done. An analysis of the structure of localbudget revenues in Ukraine in 2017 has been conducted. Describes the possible risks in theprocess of decentralization.The directions of improvement of interbudgetary relations in the conditions ofdecentralization in the context of solving the problems of the reformed pension systemdevelopment in modern Ukraine are grounded. It is determined that the improvement of thecurrent pension system has a multi-faceted nature and is designed for a long-term perspective,which consists in the implementation of already adopted legislative acts, identifying theirshortcomings and developing proposals for improving the system of state regulation in this area.The field of application of results. In the field of economic sciences and in the practicalactivity of the structural units of the Pension Fund of Ukraine.Conclusions. The main results of the study and its theoretical and methodological resultscan be reduced to the following: pension provision and its level determine the economic andsocial situation of the population of the country, forms a system of social protection, the researchproves that the state conducts. The pension reform, while not having the necessary amount offinancial resources, has identified an important role in framing intergovernmental fiscal relationsand anticipating the risks that may arise, and taking measures aimed at preventing them in theprocess of decentralization.
SCIENTIFIC AND METHODOLOGICAL SUPPORT OF IMPROVEMENT OF THE MANAGEMENT SYSTEM OF LOGISTIC ACTIVITIES OF THE ENTERPRISE
Authors: ZALOZNOVA YU. , TRUSHKINA N.
Published: April 2019

Topicality. The issues of improving the management of logistics activities of enterprises are currently actualized. The logistics component is becoming strategically the most important factor that appear in the financial results of the enterprises. Logistics activity is the main centre of cost optimization and, as a consequence, the lever to raise the level of profitability, as the supply chain accounts for a substantial part of the cost of the enterprise. Thus, in modern conditions of managing one of the most important reserves of cost reduction and increase of efficiency of functioning of domestic enterprises is formation of system of management of logistic activities using a systematic approach.Aim and tasks. The aim of this study is to develop scientific and methodological support of improving the management system of logistic activities of the company.Research results. The concept and definition of the main elements of the term «management system of logistic activities of an enterprise» have been clarified. The structural and structural-functional schemes of formation of management system of logistic activities of the enterprise have been proposed.To improve the management system of logistic activities of the enterprise a set of proposals has been developed on: the management of material and technical supply, the inventory management, traffic management, management of customer service processes, sales activity management, risk management of logistics activities in the risk management system of enterprises, improvement of pricing, information support of the organization of processes of logistic activity on the basis of use of modern digital technologies.Conclusions. It is proved that the implementation of proposals for the formation of the management system of logistic activities promotes cost savings for the organization of the processes of material and technical supply, reserves, transportation and sales.
PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND
Authors: Bahmut I. Yu. , Halmyz O. O. , Hramatiuk S. М. , Titkova A. V.
Published: April 2019

Taking into account the importance of platelets in the mechanisms of inflammation and the autoimmune process, the aim of this study was to experimentally answer a simple question: whether platelets in people with autoimmune euthyroidism, hyperthyroidism and hypothyroidism exhibit the characteristics of high activity. The study included 35 patients with autoimmune thyroid gland disease, positive for both TRO-Ab and Tg-Ab, and with elevated TTH, and 50 patients with elevated T4 and / or T3 concentrations and depressed levels of TTH, presence of TSHR antibodies, and / or anti-microsomal antibodies. As a result of this study, it was found that ADP-induced aggregation, that is, its parameters depend on the concentration of the aggregation inductor. According to the results of our study, we hypothesized that PMPs can interact with circulating autoantibodies and C1q involved in the formation of immune complexes, which can be a pathophysiological cause of the immune response.
ULTRASOUND STUDY OF PATIENTS WITH KELOID SCARS OF THE MAXILLOFACIAL AREA
Authors: Avetikov D. S. , Bukhanchenko O. P. , Aipert V. V. , Lokes K. P.
Published: April 2019

Despite the possibility of modern surgery and dermatological cosmetology, the problem of differential diagnosis of patients with keloid scars remains relevant and significant at present. As clinical practice shows, not just the presents and the size of functional or aesthetic defect in scar tissue changes are important, but also the degree of their negative influence on the process of physical, psychological and social adaptation of the patient. The aim of our study was to optimize and improve the effectiveness of treatment of facial keloid scarring by identifying the type of scarred skin of the head and neck, and using ultrasound examination. The ultrasound method of investigation was performed on 50 patients with keloid scars of the head and neck. Clinical study of the general characteristics of the scar was supplemented by an additional analysis of the structural features of the cicatricial tissues by ultrasound examination. For the purpose of comparison, intact skin was used. Analysis of ultrasonography allowed to determine the color echogenic pattern of keloid scars, which differed substantially from the dermis of intact skin. Among the echogenic signs of postoperative keloid scarring, one should point out an increase in the depth of cicatrix of the tissue in comparison with the thickness of the intact derma, an average of 8-11%, an average thickness of the epidermis is 18-26%, a clear boundary between intact skin and keloid scar is traced, which is a clear differential sign of this type of scar. Only in 7% of cases, we have visualized the border with the hypodermis in the peripheral edges of the scar, which indicates the infiltration character of the growth of the keloid and again proves its similarity with the tumor. Today, there is no universal method for differential diagnosis of various types of scars of the head and neck. Therefore, it is necessary to develop an informative and economically expedient method of diagnostics. Ultrasonography of scarring is a non-invasive survey method that can objectively, informatively and safely evaluate numerous anatomical structures, determine the type and depth of scar formation.
Prophylactic regimens with fluconazole for candidiasis in neonates under 1.500g: A retrospective chart review of two cohorts
Authors: Silva-Rios J. , Camargos P. , Correa L. , Romanelli R.
Published: April 2019

BACKGROUND:

The incidence rate of invasive candidiasis in newborns with birth weight below 1,500 g ranges from 2% to 8%, and fluconazole prophylaxis in neonatal units is recommended when the incidence of invasive candidiasis is higher than 5%. This study aimed to compare the effectiveness of targeted prophylaxis and universal prophylaxis with fluconazole in the prevention of invasive candidiasis.

METHODS:

This was a historical cohort comparing the targeted prophylaxis for newborns weighing less than 1,500 g and the universal prophylaxis for newborns weighing less than 1,000 g.

RESULTS:

The overall incidence rate of invasive candidiasis was 5.25% and was reduced from 7.1% to 3.72% with universal prophylaxis ( p = 0.04). In a multivariate analysis, the significant factors associated with the development of candidiasis were birth weight less than 1,000 g, prolonged hospitalization, previous surgery, prolonged use of mechanical ventilation, prior exposure to antimicrobial treatments, and use of targeted prophylaxis.

CONCLUSIONS:

Universal prophylaxis had lower incidence of invasive candidiasis, and preventive measures considering the risk factors are mandatory to reduce the incidence of invasive candidiasis.
Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma
Authors: Kolesnik D.L. , Pyaskovskaya O.N. , Yakshibaeva Yu.R. , Solyanik G.I.
Published: April 2019

Summary. The use of inhibitors of energy metabolism of malignant cells is a new promising trend in the treatment of cancer patients, based on one of the unique features of the malignant cell, namely the dominance of glycolysis over oxidative phosphorylation, even in the presence of oxygen, the so-called Warburg effect. Aim: To study time-dependent cytotoxicity of sodium dichloroacetate (DCA) and metformin (MTF) against metastatic tumor cells and action of these agents on tumor cell migration. Materials and Methods: In the study low metastatic LLC/R9 variant of Lewis lung carcinoma was used. The number of living cells in the cytotoxic test was evaluated using sulforhodamine B after 1, 2 and 3 days of cell incubation in vitro. The parameters of the sensitivity of tumor cells to the action of DCA and MTF in vitro were calculated using nonlinear and linear regression of experimental data. The effect of DCA and MTF on cellular motility in vitro was evaluated using a Boyden chamber by calculation of the number of cells that migrated to the bottom side of the filter within 3 days of incubation. The statistical analysis of the data was carried out with the use of descriptive methods, Student’s t-criterion, nonlinear, and linear regression analysis. Results: IC50 of DCA was found to be equal to 50.8 ± 7.6 mM at the first day of incubation with LLC/R9 cells and decreased by 1.9 (p < 0.05) and 2.1 (p < 0.05) times at the 2nd and 3rd days, respectively. Despite the almost identical ІC50 at the 2nd and 3rd days, an increase in the incubation period of cells with DCA for up to 3 days increased the C0 parameter, which reflects the maximum concentration of the agent that does not exhibit cytotoxic effects, by 93% (p < 0.05) compared to this at the 2nd day (16.2 ± 1.4 mM vs 8.4 ± 1.0 mM, correspondently). Unlike DCA, the LLC/R9 cell population was not homogeneous by the sensitivity to the action of MTF; at least at the 3rd day, an appearance of MTF-resistant subpopulation was observed, accounting for 35% of all cells. IC50 of MTF was equal to 12.1 ± 0.6 mM, and unlike DCA, this index progressively decreased at the 2nd and 3rd days by 1.4 (p < 0.05) and 9.3 times (p < 0.05) respectively. Action of DCA at a concentration of 25 mM alone and in combination with MTF at the concentrations of 0.1 mM and 0.7 mM resulted in an increase in cell migration by 65% (p < 0.05), 63% (p < 0.05) and 78.5% (p < 0.05), respectively. There was no significant effect of MTF on the tumor cell migration. Conclusions: The sensitivity of the metastatic Lewis lung carcinoma cells to the action of the modifiers of the energy metabolism increased significantly with an increase in the incubation period, apparently, primarily due to the shortage of nutrient substrates and, in particular, glucose, indicating the relevance of their combined use as well as with other agents, which promote the deficiency of glucose in the tumor microenvironment.
DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor
Authors: Burlaka A.A. , Vovk A.V. , Burlaka A.P. , Kolesnik O.O.
Published: April 2019

Summary. Prognosis of metastatic colorectal cancer (mCRC) patients nowadays is an important subject in the field of oncology. R0-resection of colon with primary tumor and liver metastasis remains the only treatment which significantly improves survival rate. However, recent experimental data show that surgical trauma can indirectly stimulate tumor growth due to mitochondrial dysfunction and unregulated superoxide radical (O2-) generation. Aim: To study the clinical significance of 8-oxo-2'-deoxyguanosine (8-oxodGu) marker, to assess the oncological effects of warm ischemia of liver parenchyma on disease prognosis in patients with mCRC. Material and Methods: 69 urine 24-hour volume tests of patients with mCRC and 17 healthy individuals were studied. Urine 8-oxodGu level was measured using spectrophotometric method with pre-solid phase DNA extraction. The energy system and hepatocyte detoxification system state, levels of O2- in tumor tissue were determined using the method of electron paramagnetic resonance (EPR) and SpinTraps technology at room temperature. Experiments were carried out on a computerized EPR spectrometer RE-1307. EPR spectra were recorded at temperature of liquid nitrogen (–196 °C) in paramagnetically pure quartz dewar on a computerized spectrometer PE-1307 with resonator H011. Error of the method of spectrum integration and spread of spectrum reproduction of one sample was not more than 3%. Results: The average level of marker in healthy individuals was 0.244 ± 0.063 nM/kg ∙ day, whereas before the resection and on day 3 after the R0-resection of liver in mCRC patients was 3.42 ± 0.18 nM/kg ∙ day and 2.12 ± 0.08 nM/kg ∙ day (p < 0.05), respectively. On day 3 after the liver resection due to its metastatic lesions with a total duration of warm ischemia period < 30 min and > 30 min have had marker at level 2.108 ± 0.13 nM/kg ∙ day and 2.9883 ± 0.159 nM/kg ∙ day (p < 0.0001), respectively. The volume of metastatic tissue significantly and directly correlated with the level of urine 8-oxodGu (R2 = 0.54, 95% CI 0.037–0.0991, p < 0.0001), also duration of surgical intervention (≥ 300 min) and duration of worm liver ischemia (> 30 min) during the surgery significantly increased urine level of 8-oxodGu (R2 = 0.54, 95% CI 0.001–0.004, p < 0.001). Conclusions: Warm liver ischemia (> 30 min), long-term surgical intervention (≥ 300 min) and metastatic tissue volume (≥ 12 cm3) in liver parenchyma in mCRC patients significantly increase urine 8-oxodGu levels. R0-resection of liver metastases in mCRC patients decreases urine 8-oxodGu levels already on day 3 after the surgery. 8-oxodGu is a new factor of oncological prognosis in patients with mCRC.