bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S2 from EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer
Authors: Okada Yasuyuki , Kimura Tetsuo , Nakagawa Tadahiko , Okamoto Koichi , Fukuya Akira , Goji Takahiro , Fujimoto Shota , Sogabe Masahiro , Miyamoto Hiroshi , Muguruma Naoki , Tsuji Yasushi , Okahisa Toshiya , Takayama Tetsuji
Published: April 2023

The genetic alteration of colorectal cancer cell lines
Table S1 from EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer
Authors: Okada Yasuyuki , Kimura Tetsuo , Nakagawa Tadahiko , Okamoto Koichi , Fukuya Akira , Goji Takahiro , Fujimoto Shota , Sogabe Masahiro , Miyamoto Hiroshi , Muguruma Naoki , Tsuji Yasushi , Okahisa Toshiya , Takayama Tetsuji
Published: April 2023

The colorectal cancer cell lines and their culture conditions
Figure S3 from EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer
Authors: Okada Yasuyuki , Kimura Tetsuo , Nakagawa Tadahiko , Okamoto Koichi , Fukuya Akira , Goji Takahiro , Fujimoto Shota , Sogabe Masahiro , Miyamoto Hiroshi , Muguruma Naoki , Tsuji Yasushi , Okahisa Toshiya , Takayama Tetsuji
Published: April 2023

The activity of cell surface EGFR and total EGFR.
Figure S1 from EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer
Authors: Okada Yasuyuki , Kimura Tetsuo , Nakagawa Tadahiko , Okamoto Koichi , Fukuya Akira , Goji Takahiro , Fujimoto Shota , Sogabe Masahiro , Miyamoto Hiroshi , Muguruma Naoki , Tsuji Yasushi , Okahisa Toshiya , Takayama Tetsuji
Published: April 2023

The relative amount of EGFR labeled with cetuximab.
Supplementary Table 1 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

XLSX file - 91K, List of complete protein identification results from LKB1 IP complex by LC MS/MS analysis in A549 and H460 LKB1 cells.
Supplementary Table 1 from Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3
Authors: di Martino Erica , Kelly Gavin , Roulson Jo-An , Knowles Margaret A.
Published: April 2023

Supplementary Table 1. Clinico-pathological characteristics and FGFR3 mutation status of the tumours used for the mRNA study
Supplementary Figure 6 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

PDF file - 50K, LKB1 inhibits cyclin D, c-Myc and VEGF expression in lung cancer cells.
Supplementary Figure 1 from Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3
Authors: di Martino Erica , Kelly Gavin , Roulson Jo-An , Knowles Margaret A.
Published: April 2023

Supplementary Figure 1. TACSTD1 protein expression in normal bladder (A) and pTaG2 tumours (B, C); HAS3 protein expression in normal bladder (D) and pTaG2 tumours (E, F). Original magnification x400. Horizontal bar indicates 20 µm.
Supplementary Figure 5 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

PDF file - 105K, Decreased expression of CD44 in LKB1 proficient lung cancer cells by immunofluorescent analysis.
Supplementary Figure 3 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

PDF file - 332K, Identification of LKB1 tumor suppressor network by co-IP LC MS/MS analysis.
Supplementary Figure 2 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

PDF file - 185K, LKB1 suppresses tumor formation in vivo mouse orthotopic human lung tumor model.
Supplementary Figure 1 from Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells
Authors: Jian Shu-Fang , Hsiao Chang-Chun , Chen Shin-Yi , Weng Ching-Chieh , Kuo Tzu-Lei , Wu Deng-Chyang , Hung Wen-Chun , Cheng Kuang-Hung
Published: April 2023

PDF file - 20K, LKB1 induces cell cycle arrest and increases the percentage of A549 cells in G0/G1.
Supplementary Table Legends from Differential Expression of Stress and Immune Response Pathway Transcripts and miRNAs in Normal Human Endothelial Cells Subjected to Fractionated or Single-Dose Radiation
Authors: Palayoor Sanjeewani T. , John-Aryankalayil Molykutty , Makinde Adeola Y. , Falduto Michael T. , Magnuson Scott R. , Coleman C. Norman
Published: April 2023

PDF - 61K, Legends for Supplementary Tables
Supplementary table 1 from β-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation
Authors: Kallifatidis Georgios , Munoz Daniel , Singh Rajendra Kumar , Salazar Nicole , Hoy James J. , Lokeshwar Bal L.
Published: April 2023

The primary antibodies used were: Î²-Actin (Cell Signaling, #5125s), Î²-arrestin-2 Antibody (SantaCruz Biotechnology, sc-13140), Akt Antibody (Cell Signaling, # 9272), phospho-Akt (pT308) (epitomics, #2214-1), phospho-Akt (pS473) (epitomics, #2118-1), Cyclin A (Cell Signaling, # 4656s), Cyclin D1 (Abcam, ab 134175), CXCR7 Antibody (Proteintech, 20423-1-AP, and customized Antibody from Abmart, GeneTech), EGFR Antibody (Cell Signaling, #2646), phospho-EGFR (pY1110) (Abcam, ab68470, ab47370), phospho-EGFR (pY1068) (Epitomics, 1138-1), Lamin A/C (epitomics, 2966-1), phospho-p44/42 MAPK (pERK1/2) (cell signaling, #9106s), p44/42 MAPK (cell signaling, #9102), Src Family (Tyr416) Antibody (Cell Signaling, #2108), phospho-Src Family (pY416) Antibody (Cell Signaling, #2101), É‘-Tubulin Antibody (Cell Signaling, #2144). Blots were probed with a 1:10,000 dilution of an anti-rabbit or anti-mouse horseradish peroxidase-conjugated secondary antibody (Cell Signaling).
Supplementary Table 1 from Differential Expression of Stress and Immune Response Pathway Transcripts and miRNAs in Normal Human Endothelial Cells Subjected to Fractionated or Single-Dose Radiation
Authors: Palayoor Sanjeewani T. , John-Aryankalayil Molykutty , Makinde Adeola Y. , Falduto Michael T. , Magnuson Scott R. , Coleman C. Norman
Published: April 2023

PDF - 22K, Genes differentially expressed (> 2-fold change, P < 0.05) in response to SD and MF irradiations were classified into functional categories by gene ontology classification. Enrichment of individual functional gene categories was determined by hypergeometric distribution of P values obtained from comparison of the number of the number of genes differentially expressed to the number of annotated genes in each category.
Figure S4 from MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling
Authors: McNew Kelsey L. , Whipple William J. , Mehta Anita K. , Grant Trevor J. , Ray Leah , Kenny Connor , Singh Anurag
Published: April 2023

Regulation of pro-inflammatory cytokine expression and by activated KRAS and BMP receptor signaling.
Supplemental Figure 2 from Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, in Lung Adenocarcinoma
Authors: Caswell Deborah R. , Chuang Chen-Hua , Ma Rosanna K. , Winters Ian P. , Snyder Eric L. , Winslow Monte M.
Published: April 2023

SELENBP1 expression correlates with NKX2-1 and NKX2-1 target gene expression in human lung adenocarcinoma, and is identified as a potential direct target of Nkx2-1 using an Nkx2-1 ChIP-seq dataset from a mouse model of lung adenocarcinoma.
Supplemental Figure 1 from TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma
Authors: Cabal-Hierro Lucia , O'Dwyer Peter J.
Published: April 2023

TNF and SN38 combination in HT29 cells induces both apoptosis and necrosis.
Supplemental Figure 2b from Proteomic Characterization of Head and Neck Cancer Patient–Derived Xenografts
Authors: Li Hua , Wheeler Sarah , Park Yongseok , Ju Zhenlin , Thomas Sufi M. , Fichera Michele , Egloff Ann M. , Lui Vivian W. , Duvvuri Umamaheswar , Bauman Julie E. , Mills Gordon B. , Grandis Jennifer R.
Published: April 2023

Primary HNSCC and PDX jitter plots for data range visualization. 173 primary HNSCC and 12 PDXs are plotted in separate columns by protein. B) 64 proteins expressed at significantly different levels in both primary HNSCC and PDX.
Supplemental data figure 2 from A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity
Authors: Mysore Veena S. , Szablowski Jerzy , Dervan Peter B. , Frost Patrick J.
Published: April 2023

This is supplemental data demonstrating the homing of 8226 human MM tumor cells to the bone marrow microenvironment of NOG mice in vivo.
Patient Clinicopathological Data for Tissue Microarray from PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27
Authors: Link Laura A. , Howley Breege V. , Hussey George S. , Howe Philip H.
Published: April 2023

S3. Patient vital status, recurrence status, and time to death or recurrence for tissue microarray analysis.
Supplementary Tables from Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
Authors: Wilson Jennifer L. , Kefaloyianni Eirini , Stopfer Lauren , Harrison Christina , Sabbisetti Venkata S. , Fraenkel Ernest , Lauffenburger Douglas A. , Herrlich Andreas
Published: April 2023

Tables for all scoring methods and gene expression accession numbers.
Supplementary Figure S1 from miR-211-5p Suppresses Metastatic Behavior by Targeting SNAI1 in Renal Cancer
Authors: Wang Kefeng , Jin Wei , Jin Peng , Fei Xiang , Wang Xia , Chen Xiaonan
Published: April 2023

Supplementary Figure S1
Supplementary Figure Legends from miR-211-5p Suppresses Metastatic Behavior by Targeting SNAI1 in Renal Cancer
Authors: Wang Kefeng , Jin Wei , Jin Peng , Fei Xiang , Wang Xia , Chen Xiaonan
Published: April 2023

Supplementary Figure Legends
Supplementary Table 1 from Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma
Authors: Schulze Heuling Eva , Knab Felix , Radke Josefine , Eskilsson Eskil , Martinez-Ledesma Emmanuel , Koch Arend , Czabanka Marcus , Dieterich Christoph , Verhaak Roel G. , Harms Christoph , Euskirchen Philipp
Published: April 2023

Telomerase promoter genotype and MGMT status in matched glioblastoma tumor vs. cell line pairs.
Supplementary Figure 5 from NEDD9 Regulates Actin Dynamics through Cortactin Deacetylation in an AURKA/HDAC6–Dependent Manner
Authors: Kozyreva Varvara K. , McLaughlin Sarah L. , Livengood Ryan H. , Calkins Robin A. , Kelley Laura C. , Rajulapati Anuradha , Ice Ryan J. , Smolkin Matthew B. , Weed Scott A. , Pugacheva Elena N.
Published: April 2023

PDF - 131K, Supplementary Figure 5. Rescue of NEDD9-knockdown with CTTN deacetylation mimicking mutant. Immunoprecipitation of CTTN or myc-CTTN with anti-CTTN or anti-myc antibodies from MDA-MB-231 cells co-transfected with siRNA against NEDD9 (N1) and either empty vector (-) or myc-fusion CTTN deacetylation mimicking mutant (9KR). Western blot analysis with anti-acetyl-lysine antibodies shows acetylation of endogenous CTTN and lack of acetylation on myc-tagged exogenous CTTN 9KR mutant. Expression of both endogenous and exogenouse CTTN shown by probing with anti-CTTN and anti-myc antibodies, respectively.
Supplementary Figure 3 from NEDD9 Regulates Actin Dynamics through Cortactin Deacetylation in an AURKA/HDAC6–Dependent Manner
Authors: Kozyreva Varvara K. , McLaughlin Sarah L. , Livengood Ryan H. , Calkins Robin A. , Kelley Laura C. , Rajulapati Anuradha , Ice Ryan J. , Smolkin Matthew B. , Weed Scott A. , Pugacheva Elena N.
Published: April 2023

PDF - 95K, Supplementary Figure 3. Morphometric analysis of CTTN distribution. Intensity of signal for IF staining for CTTN and actin was calculated based on 3D reconstracted confocal projections of the whole cell along the line drawn across the cell length starting from morphologically distinct lamellipodia edge-point A on cell diagram (also on Fig.3A), through the nucleus towards the rear end of the cell- point B on cell diagram (also on Fig.3A). Intensity of staining was counted using ImageJ for each pixel along the line as a Sum of Max Grey value in each of 10 confocal sections taken at 0.2!m steps comprasing the Z-stack for each cell. MDA-MB-231 cells nucleofected with either siCon or siNEDD9 (10 cells per group) were evaluated. Length of each cell was taken as 100% and distribution of CTTN and actin in relation to percent of the cell length was calculated.
Supplementary Figure 2 from NEDD9 Regulates Actin Dynamics through Cortactin Deacetylation in an AURKA/HDAC6–Dependent Manner
Authors: Kozyreva Varvara K. , McLaughlin Sarah L. , Livengood Ryan H. , Calkins Robin A. , Kelley Laura C. , Rajulapati Anuradha , Ice Ryan J. , Smolkin Matthew B. , Weed Scott A. , Pugacheva Elena N.
Published: April 2023

PDF - 606K, Supplementary Figure 2. A. Quantification of Boyden chamber migration assay for MDA-MB-231 cells expressing shControl (shCon) or shNEDD9 (shN1, shN2). Data presented as average mean values of relative fluorescense intensity units (RFU) with +S.E.M from three independent experiments, with triplicates per each treatment condition. One-way ANOVA *p=0.026 for shCon/shN1; **p=0.0003 for shCon/shN2. B. WB analysis of NEDD9 expression in the cells as in (A) with anti-NEDD9 and -GAPDH antibodies. C. IP of NEDD9 using anti-GFP tag antibodies from HEK293T cells cotransfected with indicated constructs: GFP-fusion C-terminus truncation mutant of human NEDD9 (N626-834aa) or full length (FL) and myc-tagged C-terminus (351-546aa) or N-terminus truncation (1-350aa) mutant of human CTTN for 24h. WB with anti-GFP, -myc antibodies.
Data Supplement from FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma
Authors: Weiss Michele B. , Abel Ethan V. , Dadpey Neda , Aplin Andrew E.
Published: April 2023

Supplementary Figures S1-S2. Supplementary Figure S1. 1205Lu cells were transfected with a control non-targeting siRNA or one of two different FOXD3 targeting siRNAs. Lysates and mRNA were harvested four days after siRNA transfection. In addition, control siRNA treated cells were treated for 24 hours with the RAF inhibitor PLX4720 (1 μM) as a positive control for FOXD3 expression. Western blots and quantitative RT-PCR were performed. Columns, average of three independent experiments; bars, SD; *p<0.05, **p<0.01. Supplementary Figure S2. FOXD3 does not alter EMT protein expression consistently across a panel of human melanoma cell lines. (A) A time course of FOXD3-V5 ectopic expression was performed with the addition of doxycycline to WM793TR-, WM115TR-, 1205LuTR-, and A375TR-FOXD3-V5 cells. Protein lysates were assessed for expression changes of a panel of EMT-promoting factors. For proteins with undetectable levels, normal human melanocyte lysates were also run as a positive control of protein expression. (B) Western blot analysis comparing 1205Lu parental cell lysates to A375 lysates.
Supplementary Figures S1 and S2 from Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade
Authors: Williams Michelle M. , Lee Linus , Hicks Donna J. , Joly Meghan M. , Elion David , Rahman Bushra , McKernan Courtney , Sanchez Violeta , Balko Justin M. , Stricker Thomas , Estrada Monica Valeria , Cook Rebecca S.
Published: April 2023

S1. CCLE-curated cancer cells were grouped according to tumor type and assessed for miRNA expression for BCL2 and BCL2L1 (Bcl-xL) using cBio portal (www.cbio.org). S2. Whole cell lysates form a panel of breast cancer cell lines were assessed by western analysis (BL = Basal-like).
Supplementary Figure S3 from Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling
Authors: Jiang Hong , Wu Lisha , Chen Jing , Mishra Murli , Chawsheen Hedy A. , Zhu Haining , Wei Qiou
Published: April 2023

The layout of the human protein profiler phospho-RTK assay (A) and list of RTKs (B).
Supplementary Figure S2 from Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling
Authors: Jiang Hong , Wu Lisha , Chen Jing , Mishra Murli , Chawsheen Hedy A. , Zhu Haining , Wei Qiou
Published: April 2023

EGF induces a dose-dependent increase of cell invasion and the effect of Srx knockdown in HCT116 cells. Compared to control cells, * p< 0.05 (t test).
Supplementary Figure/Table Legends from Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2
Authors: Brown Caitlin W. , Brodsky Alexander S. , Freiman Richard N.
Published: April 2023

Supplementary Figure/Table Legends
Supplementary Figure 1, Tables 1 - 3 from Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2
Authors: Brown Caitlin W. , Brodsky Alexander S. , Freiman Richard N.
Published: April 2023

Supplementary Figure 1. Reduction in Notch1 levels did not alter levels of col4α2 expression. Supplementary Table 1. List of Antibodies. Supplementary Table 2. List of Primers. Supplementary Table 3. Increased Notch3 expression correlates with increased col4α2 in the human ovarian tumor dataset from TCGA.
Table S2 from Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues
Authors: Cacciatore Stefano , Zadra Giorgia , Bango Clyde , Penney Kathryn L. , Tyekucheva Svitlana , Yanes Oscar , Loda Massimo
Published: April 2023

Analysis of the metabolites found in the supernatant categorized by superclass, class, subclass, substituent, physical/chemical properties, and pathways.
Supplementary Table 2 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
Authors: Aronchik Ida , Appleton Brent A. , Basham Stephen E. , Crawford Kenneth , Del Rosario Mercedita , Doyle Laura V. , Estacio William F. , Lan Jiong , Lindvall Mika K. , Luu Catherine A. , Ornelas Elizabeth , Venetsanakos Eleni , Shafer Cynthia M. , Jefferson Anne B.
Published: April 2023

PDF file - 28K, Percent Inhibition of MDA-MB-231 or H358 cells when grown as colonies on Scivax plates in the presence of LJI308.
Supplementary Figure Legends from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
Authors: Aronchik Ida , Appleton Brent A. , Basham Stephen E. , Crawford Kenneth , Del Rosario Mercedita , Doyle Laura V. , Estacio William F. , Lan Jiong , Lindvall Mika K. , Luu Catherine A. , Ornelas Elizabeth , Venetsanakos Eleni , Shafer Cynthia M. , Jefferson Anne B.
Published: April 2023

PDF file - 74K
Supplemental Figure 1 from PKCϵ Is an Essential Mediator of Prostate Cancer Bone Metastasis
Authors: Gutierrez-Uzquiza Alvaro , Lopez-Haber Cynthia , Jernigan Danielle L. , Fatatis Alessandro , Kazanietz Marcelo G.
Published: April 2023

List of 84 genes analyzed by qPCR in control (NTC) or PKCε-depleted cells, using the Human Tumor Metastasis RT2 Profiler PCR array (Qiagen).
Supplementary Figure 2 from PAI-1 Leads to G1-Phase Cell-Cycle Progression through Cyclin D3/cdk4/6 Upregulation
Authors: Giacoia Evan Gomes , Miyake Makito , Lawton Adrienne , Goodison Steve , Rosser Charles J.
Published: April 2023

PDF file - 148KB, Genetic manipulation of PAI-1 in human tumor cell lines.
Supplementary Tables S1-S4 from AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition
Authors: Shah Khyati N. , Mehta Kshama R. , Peterson David , Evangelista Marie , Livesey John C. , Faridi Jesika S.
Published: April 2023

PDF file - 184 KB, Legends for Supplementary Tables: Supplementary Table S1A: Primers used for real-time RT-PCR gene regulation and confirmation Supplementary Table S1B: Microarray data deposited into the Gene Expression Ominbus (GSE34291) using Agilent's platform GPL4133 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34291) Supplementary Table S2: Genes modified upon hormonal treatment in MCF-7 and Akt3 overexpressing cells Supplementary Table S3: Ingenuity database gene networks associated with hormonal treatment and Akt over-expression Supplementary Table S4: Comparison of Fold change of selected genes by microarray analysis and RT-qPCR
Supplementary Figure 3 from A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G.
Published: April 2023

PDF file - 172KB, A: Strategy for filtering and selecting the FPG signature. We selected those probes that were common to the three types of fibroblasts with RMA-normalized values >4 (10,779 probes). By this means we eliminated many genes that either were not represented in any of the classes or whose expression values were so low that they could be confused with background noise. B: In a second step, we selected genes that fulfilled the condition: (logFC) NCF vs. CAF-PT >1.5 and CAF-PT vs. CAF-LM >1.5 (179 genes) and CAF-PT vs. NCF >1.5 and CAF-LM vs. CAF-PT >1.5 (98 genes), and with values of q<0.05. C: Unsupervised hierarchical standardized heatmap of the 277-gene signature in the 34 fibroblasts samples. Columns represent fibroblast samples and are arranged along the X axis; genes are arranged along the Y axis. The sequence of normal colonic fibroblasts (NCF) > carcinoma-associated fibroblasts from the primary tumour (CAF-PT) > carcinoma-associated fibroblasts from the liver metastasis (CAF-LM) had been assimilated to cancer progression. Blue and red indicate overexpression and underexpression, respectively. D: Signature optimization by PAM analysis in the training set (34 fibroblast samples), showing the minimum 25 genes providing the lowest misclassification error (Best 25 genes out off 277 gene signature). PAM selects a set of probes according to a threshold value, usually containing those probes that minimize the cross-validation error. The 25 genes are those selected by PAM analysis from the 277 probes common to the three types of fibroblasts but which were differentially expressed following the signature definition log n-fold change (logFC) values of NCF vs. CAF-PT >1.5 and CAF-PT vs. CAF-LM >1.5 (179 genes) and CAF-PT vs. NCF >1.5 and CAF-LM vs. CAF-PT >1.5 (98 genes), and with values of q<0.05. E: For the 25 genes described in C the misclassification error (confusion with the CAF-PT class) was zero for NCF and CAF-LM classes. F: Representative western blot of selected genes (SLC7A2, ARHGDIB, TFGB2) in four samples of each fibroblast class. Tubulin was used to normalize expression (loading control). As clearly depicted in the graph SLC7A2, ARHGDIB and TGFB2 were overexpressed in CAF-LM vs CAF-PT and CAF-PT vs NCF.
Supplementary Figure 2 from A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G.
Published: April 2023

PDF file - 173KB, Overview and design of the development of the 277-signature, 25- and 19-gene classifiers.
Supplementary Figure 1 from A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G.
Published: April 2023

PDF file - 2635KB, Fibroblast characterization.
Supplemental figure legends from Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors
Authors: Hensel Jonathan , Duex Jason E. , Owens Charles , Dancik Garrett M. , Edwards Michael G. , Frierson Henry F. , Theodorescu Dan
Published: April 2023

Supplemental figure legends
Supplemental Figure 2 from Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors
Authors: Hensel Jonathan , Duex Jason E. , Owens Charles , Dancik Garrett M. , Edwards Michael G. , Frierson Henry F. , Theodorescu Dan
Published: April 2023

Supplemental Figure 2. Knockdown of TGFBR2 reduces the anchorage independent growth induced by loss of IQGAP1.
Data Supplement from Altered Endosome Biogenesis in Prostate Cancer Has Biomarker Potential
Authors: Johnson Ian R.D. , Parkinson-Lawrence Emma J. , Shandala Tetyana , Weigert Roberto , Butler Lisa M. , Brooks Doug A.
Published: April 2023

Supplementary Figure 1. Confocal micrographs of endosomal markers in prostate cancer cell lines compared to non-malignant control cell lines.
Data Supplement from Altered Endosome Biogenesis in Prostate Cancer Has Biomarker Potential
Authors: Johnson Ian R.D. , Parkinson-Lawrence Emma J. , Shandala Tetyana , Weigert Roberto , Butler Lisa M. , Brooks Doug A.
Published: April 2023

Supplementary Figure 2. Time-course of transferrin uptake in prostate cell lines.
Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer
Authors: Jiao Jing , Ishikawa Tomo-O , Dumlao Darren S. , Norris Paul C. , Magyar Clara E. , Mikulec Carol , Catapang Art , Dennis Edward A. , Fischer Susan M. , Herschman Harvey R.
Published: April 2023

Keratinocytes from Cox-2deltaE Cox-2flox/flox;K14Cre+) mice undergo effective targeted Cox-2 gene deletion. Keratinocyte were isolated from Cox-2deltaE and Cox-2flox/flox (Cox-2fl/fl) mice. Briefly, skin specimens isolated from 7-9 week old mice were treated with 3 mg/ml Dispase (Invitrogen, Carlsbad, CA) for 16 hrs at 4oC, and the epidermis was separated from the dermis. The isolated keratinocytes were plated on dishes containing keratinocyte serum-free medium. After seven days of culture, DNAs from the keratinocytes were extracted and the presence of the Cox-2fl, Cox-2del and Cre alleles were examined by PCR. PCR analysis demonstrates both the presence of the Cre+ and the Cox-2del alleles in Cox-2deltaE keratinocytes and the absence of the Cre+ allele and the presence of the Cox-2fl allele in Cox-2fl/fl keratinocytes.
Supplementary Material from Novel Assay to Detect RNA Polymerase I Activity In Vivo
Authors: Guner Gunes , Sirajuddin Paul , Zheng Qizhi , Bai Baoyan , Brodie Alexandra , Liu Hester , af Hällström Taija , Kulac Ibrahim , Laiho Marikki , De Marzo Angelo M.
Published: April 2023

Supplementary table ("clinicopathological features of cases on the TMAs") and figures (1; "increased 5'ETS/45S CISH signal in cancer glands", 2; "scatterplot showing correlation between 5ʹETS/45S CISH levels by quantitative image analysis and quantitative real time PCR levels from the experiments shown in Figure 2E") S1. Increased 5ʹETS/45S CISH signals in cancer glands. S2. Scatterplot showing correlation between 5ʹETS/45S CISH levels by quantitative image analysis and quantitative real time PCR levels from the experiments shown in Figure 2E.
Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer
Authors: Jiao Jing , Ishikawa Tomo-O , Dumlao Darren S. , Norris Paul C. , Magyar Clara E. , Mikulec Carol , Catapang Art , Dennis Edward A. , Fischer Susan M. , Herschman Harvey R.
Published: April 2023

Skin and papilloma samples from Cox-2fl/fl and Cox-2deltaE littermate mice taken 18 hours after the last TPA treatment of the DMBA/TPA tumor induction protocol were immunostained for Cleaved-Caspase 3. Arrows indicate apoptotic cells.
Supplementary figure legend and table from Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy
Authors: Anjanappa Manjushree , Burnett Riesa , Zieger Michael A. , Merfeld-Clauss Stephanie , Wooden William , March Keith , Tholpady Sunil , Nakshatri Harikrishna
Published: April 2023

Figure legends for supplementary figures and a Table with patient characteristics.
Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer
Authors: Jiao Jing , Ishikawa Tomo-O , Dumlao Darren S. , Norris Paul C. , Magyar Clara E. , Mikulec Carol , Catapang Art , Dennis Edward A. , Fischer Susan M. , Herschman Harvey R.
Published: April 2023

Papillomas developed on Cox-2deltaE mice have a significantly increased percentage of small vessels and a significantly decreased percentage of (medium-sized + large-sized) vessels when compared to papillomas from littermate control Cox-2fl/fl mice. Vessel size analysis was performed with the Definiens' Tissue Studio program to determine vessel sizes from papillomas (n = 9) from Cox-2deltaE mice, papillomas (n = 19) from their littermate Cox-2fl/fl mice, papillomas (n = 9) from Cox-2deltaM mice, and papillomas (n = 10) from their Cox-2fl/fl littermate mice. Parameters were set to distinguish small vessels (<100µm2), medium-sized vessels (100-1000µm2), and large vessels (>1000µm2). The graph shows the vessel size distribution of small, medium-sized and large vessels in papillomas from each of the four cohorts. The percentage of small vessels in papillomas of Cox-2deltaE mice was significantly increased when compared to the percentage of small vessels in papillomas of their Cox-2fl/fl littermates (p = 0.003), and the percentage of (medium-sized + large vessels) was correspondingly reduced (p = 0.002). In contrast, vessel size distribution did not differ for papillomas from Cox-2deltaM mice and their Cox-2fl/fl littermates. Data were analyzed using an unpaired Student's t test. Error bars are SD. * indicates p<0.05.
Figure S3 from Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy
Authors: Anjanappa Manjushree , Burnett Riesa , Zieger Michael A. , Merfeld-Clauss Stephanie , Wooden William , March Keith , Tholpady Sunil , Nakshatri Harikrishna
Published: April 2023

The effect of HGF and IFNgamma on MCF10A-ER-SRC cells
Supplementary Figure S3 A-E from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Authors: Balestrini Alessia , Nicolas Laura , Yang-lott Katherine , Guryanova Olga A. , Levine Ross L. , Bassing Craig H. , Chaudhuri Jayanta , Petrini John H.J.
Published: April 2023

Events upstream AID-mediated switch lesion are not affected in Nbs1deltaB/deltaB Atm -/- VAV B cells
Supplementary Text and Legends from Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer
Authors: Mustachio Lisa Maria , Lu Yun , Tafe Laura J. , Memoli Vincent , Rodriguez-Canales Jaime , Mino Barbara , Villalobos Pamela Andrea , Wistuba Ignacio , Katayama Hiroyuki , Hanash Samir M. , Roszik Jason , Kawakami Masanori , Cho Kwang-jin , Hancock John F. , Chinyengetere Fadzai , Hu Shanhu , Liu Xi , Freemantle Sarah J. , Dmitrovsky Ethan
Published: April 2023

Contains supplementary methods and supplementary figure legends.
Supplementary Figure S2 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Authors: Balestrini Alessia , Nicolas Laura , Yang-lott Katherine , Guryanova Olga A. , Levine Ross L. , Bassing Craig H. , Chaudhuri Jayanta , Petrini John H.J.
Published: April 2023

Flow cytometric analysis of haematopoietic tissues
Supplementary Materials and Methods, Figure Legend from TGFβ Induces “BRCAness” and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA-Repair Genes
Authors: Liu Liang , Zhou Weiying , Cheng Chun-Ting , Ren Xiubao , Somlo George , Fong Miranda Y. , Chin Andrew R. , Li Hui , Yu Yang , Xu Yang , O'Connor Sean Timothy Francis , O'Connor Timothy R. , Ann David K. , Stark Jeremy M. , Wang Shizhen Emily
Published: April 2023

Supplementary Materials and Methods, Figure Legend from TGFβ Induces “BRCAness” and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA-Repair Genes
Visual overview from AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2
Authors: Fogarty Sarah , Ross Fiona A. , Vara Ciruelos Diana , Gray Alexander , Gowans Graeme J. , Hardie D. Grahame
Published: April 2023

Cellular stresses that increase AMP:ATP and AMP:ATP ratios activate AMPK in normal cells by promoting its phosphorylation by LKB1. This triggers inhibition of cell growth by phosphorylation of acetyl-CoA carboxylase (ACC), Raptor and other targets, and inhibition of the cell cycle by up-regulation of the cyclin-dependent kinase inhibitor, CDKN1A. This mechanism fails, due to the lack of sufficient upstream kinase activity, in tumor cells that have lost the tumor suppressor LKB1. However, it can be restored by increasing cell Ca2+ to activate the alternate Ca2+-dependent upstream kinase, CAMKK2.
Supplementary Figures and Legends S1-S4 from Long-term Tumor Adaptation after Radiotherapy: Therapeutic Implications for Targeting Integrins in Prostate Cancer
Authors: Eke Iris , Makinde Adeola Y. , Aryankalayil Molykutty J. , Reedy Jessica L. , Citrin Deborah E. , Chopra Sunita , Ahmed Mansoor M. , Coleman C. Norman
Published: April 2023

S1. Growth curves of PC3 xenograft tumors after radiation. S2. AIIB2 binds to prostate cancer cells. S3. Integrin expression is elevated after radiation in vitro and in vivo. S4. Cell cycle distribution is unchanged in PC3 long-term survivors (in vitro).
Supplementary Figure 2 from Actin-Binding Protein, Espin: A Novel Metastatic Regulator for Melanoma
Authors: Yanagishita Takeshi , Yajima Ichiro , Kumasaka Mayuko , Kawamoto Yoshiyuki , Tsuzuki Toyonori , Matsumoto Yoshinari , Watanabe Daisuke , Kato Masashi
Published: April 2023

PDF file - 32K, Transcript expression of Espin isoforms in melanocytic tumors that developed in RET-mice.
Supplementary Figure 3 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Authors: Lee Sue-Chin , Fujiwara Yuko , Liu Jianxiong , Yue Junming , Shimizu Yoshibumi , Norman Derek D. , Wang Yaohong , Tsukahara Ryoko , Szabo Erzsebet , Patil Renukadevi , Banerjee Souvik , Miller Duane D. , Balazs Louisa , Ghosh Manik C. , Waters Christopher M. , Oravecz Tamas , Tigyi Gabor J.
Published: April 2023

Supplementary Figure 3. (A) ATX and LPA receptor profiling in B16F10 cells transduced with GFP lentivirus using quantitative real-time PCR. Data are expressed as mean {plus minus} SD of an experiment performed twice in quadruplicates. (B) Representative images of lungs harvested at day 21 from mice that were injected with PBS (left panel, control) and mice that were injected with 1 x 105 GFP-expressing B16F10 cells (right panel). Arrow denotes a single fluorescent tumor nodule on lung surface. Scale bar = 200 microns.
Data Supplement from Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms
Authors: Virtanen Sanna S. , Kukkonen-Macchi Anu , Vainio Minna , Elima Kati , Härkönen Pirkko L. , Jalkanen Sirpa , Yegutkin Gennady G.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 1 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Authors: Lee Sue-Chin , Fujiwara Yuko , Liu Jianxiong , Yue Junming , Shimizu Yoshibumi , Norman Derek D. , Wang Yaohong , Tsukahara Ryoko , Szabo Erzsebet , Patil Renukadevi , Banerjee Souvik , Miller Duane D. , Balazs Louisa , Ghosh Manik C. , Waters Christopher M. , Oravecz Tamas , Tigyi Gabor J.
Published: April 2023

Supplementary Figure 1. Time course of ATX activity measured in the conditioned media (CM) of (A) MM1 rat hepatocarcinoma, (B) HUVEC, (C) RLMVEC, and (D) isolated murine mesothelial cells. Control represents media that were not exposed to cells. Data are expressed as mean {plus minus} SD of an experiment performed three times in triplicates.
Supplemental Figure Legends from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Authors: Lee Sue-Chin , Fujiwara Yuko , Liu Jianxiong , Yue Junming , Shimizu Yoshibumi , Norman Derek D. , Wang Yaohong , Tsukahara Ryoko , Szabo Erzsebet , Patil Renukadevi , Banerjee Souvik , Miller Duane D. , Balazs Louisa , Ghosh Manik C. , Waters Christopher M. , Oravecz Tamas , Tigyi Gabor J.
Published: April 2023

Supplemental Figure Legends. Supplemental Figure Legends
Data Supplement from Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms
Authors: Virtanen Sanna S. , Kukkonen-Macchi Anu , Vainio Minna , Elima Kati , Härkönen Pirkko L. , Jalkanen Sirpa , Yegutkin Gennady G.
Published: April 2023

Supplementary Figure S1. The effect of adenosine on the expression of focal adhesion kinase (FAK) in PC-3 cells.
Data Supplement from Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms
Authors: Virtanen Sanna S. , Kukkonen-Macchi Anu , Vainio Minna , Elima Kati , Härkönen Pirkko L. , Jalkanen Sirpa , Yegutkin Gennady G.
Published: April 2023

Supplementary Figure S3. Intracellular nucleotide and nucleoside levels in control and adenosine-treated PC-3 cells.
Supplemental Table 1 from Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth
Authors: Guan Xiangnan , LaPak Kyle M. , Hennessey Rebecca C. , Yu Christina Y. , Shakya Reena , Zhang Jianying , Burd Christin E.
Published: April 2023

Real-time PCR primer sets for the analysis of SASP gene expression.
Data Supplement from Targeting mTORC1–Mediated Metabolic Addiction Overcomes Fludarabine Resistance in Malignant B Cells
Authors: Sharma Arishya , Janocha Allison J. , Hill Brian T. , Smith Mitchell R. , Erzurum Serpil C. , Almasan Alexandru
Published: April 2023

Supplementary Figure S1. P70S6k knockdown does not impact on cell death in Nalm-6 cells.
Supplementary Figure Legends, Figures 1 - 4 from EZH2: Not EZHY (Easy) to Deal
Authors: Deb Gauri , Singh Anup Kumar , Gupta Sanjay
Published: April 2023

PDF file - 433KB, S1: CIP2A and SET levels are increased in some primary human pancreatic cancer samples. S2: Increased expression of PP2A inhibitors trend toward decreased PP2A activity, which trends toward increased Myc expression and Myc protein stabilization in pancreatic cancer cell lines. S3: OP449 treatment decreases c-Myc DNA binding and half-life in pancreatic cancer cell lines, and SET knockdown reduces OP449 sensitivity. S4: OP449 treatment reduces pancreatic cancer cell migration in vitro, proliferation in vivo, and increases tumor cell apoptosis in vivo.
Supplemental Figure 2: Activation of the AHR with a mixture of agonists' results in further increase in SCC2 cell migration. from Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis
Authors: Stanford Elizabeth A. , Ramirez-Cardenas Alejandra , Wang Zhongyan , Novikov Olga , Alamoud Khalid , Koutrakis Petros , Mizgerd Joseph P. , Genco Caroline A. , Kukuruzinska Maria , Monti Stefano , Bais Manish V. , Sherr David H.
Published: April 2023

A) Representative images of HSC-3 cell migration at 24 hours after cells were cultured to confluence, scratched, and treated with vehicle, 10 μM B(a)P, 1 μM PYO, particulate matter 2.5 um (PM2.5), 10 μM B(a)P and 1 μM PYO, or 10 μM B(a)P and PM2.5. Data are representative of 3 independent experiments. Vertical black lines indicate the borders of the original scratch at zero hours. B) SCC2 cells were treated as in "A" and percent exposed area was quantified. Data from 3 experiments were normalized to results obtained with naïve cells and presented as mean percent exposed area + standard error. Asterisks indicate a significant decrease in exposed area, *p<0.05.
Supplemental Figure 1: Immortalized OSCC cell lines express AHR protein. from Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis
Authors: Stanford Elizabeth A. , Ramirez-Cardenas Alejandra , Wang Zhongyan , Novikov Olga , Alamoud Khalid , Koutrakis Petros , Mizgerd Joseph P. , Genco Caroline A. , Kukuruzinska Maria , Monti Stefano , Bais Manish V. , Sherr David H.
Published: April 2023

Expression of AHR in whole cell lysates from HSC-3 and Cal27 cells was determined by Western immunoblot analysis, using AhR-specific (1:1000, 13790#, Cell signaling), and β-actin-specific (1:2000, A5441, Sigma-Aldrich) antibodies. Cell lysates from three different experiments were prepared and tested.
Supplementary Table 3 from RNA-seq Reveals Aurora Kinase–Driven mTOR Pathway Activation in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma
Authors: Pal Sumanta K. , He Miaoling , Tong Tommy , Wu Huiqing , Liu Xueli , Lau Clayton , Wang Jin-Hui , Warden Charles , Wu Xiwei , Signoretti Sabina , Choueiri Toni K. , Karam Jose A. , Jones Jeremy O.
Published: April 2023

Fusion genes were predicted by chimerascan + deFUSE, with BLAT validation.
Supplementary files from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Authors: Laginestra Maria Antonella , Tripodo Claudio , Agostinelli Claudio , Motta Giovanna , Hartmann Sylvia , Döring Claudia , Rossi Maura , Melle Federica , Sapienza Maria Rosaria , Tabanelli Valentina , Pileri Alessandro , Fuligni Fabio , Gazzola Anna , Mannu Claudia , Sagramoso Carlo Alberto , Lonardi Silvia , Lorenzi Luisa , Bacci Francesco , Sabattini Elena , Borges Anita , Simonitsch-Klupp Ingrid , Cabecadas Jose , Campo Elias , Rosai Juan , Hansmann Martin-Leo , Facchetti Fabio , Pileri Stefano Aldo
Published: April 2023

Supplementary figures 1-5, supplementary tables 1-9
Supplemental Video 2 from The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma
Authors: Cheerathodi Mujeeburahiman , Avci Naze G. , Guerrero Paola A. , Tang Leung K. , Popp Julia , Morales John E. , Chen Zhihua , Carnero Amancio , Lang Frederick F. , Ballif Bryan A. , Rivera Gonzalo M. , McCarty Joseph H.
Published: April 2023

Raich-Rac1 Imaging, video 2
Video 1 from Therapeutic Targeting of Nuclear γ-Tubulin in RB1-Negative Tumors
Authors: Lindström Lisa , Villoutreix Bruno O. , Lehn Sophie , Hellsten Rebecka , Nilsson Elise , Crneta Enisa , Olsson Roger , Alvarado-Kristensson Maria
Published: April 2023

Video 1. Fluorescence images from time-lapse confocal microscopy using a laser-scanning confocal microscope of a mitotic U2OS cell transiently expressing pmTurquoise2-tagged- ÃŽÂ±-tubulin (red) treated with DMSO (vehicle). Images were collected every 30 s.
Supplementary Methods and Figure Legends from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Authors: Whitsett Timothy G. , Mathews Ian T. , Cardone Michael H. , Lena Ryan J. , Pierceall William E. , Bittner Michael , Sima Chao , LoBello Janine , Weiss Glen J. , Tran Nhan L.
Published: April 2023

PDF file - 113K
Supplementary figure S1 from Therapeutic Targeting of Nuclear γ-Tubulin in RB1-Negative Tumors
Authors: Lindström Lisa , Villoutreix Bruno O. , Lehn Sophie , Hellsten Rebecka , Nilsson Elise , Crneta Enisa , Olsson Roger , Alvarado-Kristensson Maria
Published: April 2023

Supplementary figure S1. CDA treatment induces a G2/M cell cycle arrest.
Supplementary Figure 2 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Authors: Whitsett Timothy G. , Mathews Ian T. , Cardone Michael H. , Lena Ryan J. , Pierceall William E. , Bittner Michael , Sima Chao , LoBello Janine , Weiss Glen J. , Tran Nhan L.
Published: April 2023

PDF file - 159K, Mcl-1 and Fn14 gene expressions correlate in squamous cell lung carcinoma.
Supplementary Table S3 from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation
Authors: Bell Jonathan B. , Eckerdt Frank , Dhruv Harshil D. , Finlay Darren , Peng Sen , Kim Seungchan , Kroczynska Barbara , Beauchamp Elspeth M. , Alley Kristen , Clymer Jessica , Goldman Stewart , Cheng Shi-Yuan , James C. David , Nakano Ichiro , Horbinski Craig , Mazar Andrew P. , Vuori Kristiina , Kumthekar Priya , Raizer Jeffrey , Berens Michael E. , Platanias Leonidas C.
Published: April 2023

This table shows genes enriched in untreated and ATO-treated polysomes. Relates to Figure 4D.
Supplementary Figure 1 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Authors: Whitsett Timothy G. , Mathews Ian T. , Cardone Michael H. , Lena Ryan J. , Pierceall William E. , Bittner Michael , Sima Chao , LoBello Janine , Weiss Glen J. , Tran Nhan L.
Published: April 2023

PDF file - 26K, Chemical scaffold structure of EU5148.
Supplemental Figure 4 from USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
Authors: Henrich Ian C. , Young Robert , Quick Laura , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

USP6-dependent IFN-induced apoptosis in multiple Ewing sarcoma lines
Supplemental Figure 3 from USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
Authors: Henrich Ian C. , Young Robert , Quick Laura , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

Enhanced IFN response induced by USP6 in additional Ewing sarcoma lines
Supplemental Figure 2 from USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
Authors: Henrich Ian C. , Young Robert , Quick Laura , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

Quantification of STAT1 and STAT3 phosphorylation
Supplemental Figure 1 from USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
Authors: Henrich Ian C. , Young Robert , Quick Laura , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

Methylation of the USP6 promoter in Ewing sarcoma lines
Supplemental Figure Images from HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells
Authors: Romeo Carmella , Weber Matthew C. , Zarei Mahsa , DeCicco Danielle , Chand Saswati N. , Lobo Angie D. , Winter Jordan M. , Sawicki Janet A. , Sachs Jonathan N. , Meisner-Kober Nicole , Yeo Charles J. , Vadigepalli Rajanikanth , Tykocinski Mark L. , Brody Jonathan R.
Published: April 2023

Supplemental Figure Images
Figure S5 from Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian
Published: April 2023

Schematic model for (A) the generation of radiation resistant SW1463RES and (B) whole genome expression profiling experiments.
Video S7 from Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior
Authors: Jones Brandon C. , Kelley Laura C. , Loskutov Yuriy V. , Marinak Kristina M. , Kozyreva Varvara K. , Smolkin Matthew B. , Pugacheva Elena N.
Published: April 2023

Ibidi chemotactic invasion of MDA-MB-231 cells with AURKA and ROCK inhibition