bluuebunny/crossref_metadata_2025 huggingface dataset:
Labeling adipose derived stem cell sheet by ultrasmall super-paramagnetic Fe3O4 nanoparticles and magnetic resonance tracking in vivo
Authors: Zhou Shukui , Yin Ting , Zou Qingsong , Zhang Kaile , Gao Guo , Shapter Joseph G. , Huang Peng , Fu Qiang
Published: February 2017

Cell sheet therapy has emerged as a potential therapeutic option for reparation and reconstruction of damaged tissues and organs. However, an effective means to assess the fate and distribution of transplanted cell sheets in a serial and noninvasive manner is still lacking. To investigate the feasibility of tracking Adipose derived stem cells (ADSCs) sheetin vivousing ultrasmall super-paramagnetic Fe3O4nanoparticles (USPIO), canine ADSCs were cultured and incubated with USPIO and 0.75 μg/ml Poly-L-Lysine (PLL) for 12 h. Labeling efficiency, cell viability, apoptotic cell rate were assessed to screen the optimum concentrations of USPIO for best labeling ADSCs. The results showed ADSCs were labeled by USPIO at an iron dose of 50 μg/ml for a 12 h incubation time, which can most efficiently mark cells and did not impair the cell survival, self-renewal, and proliferation capacity. USPIO-labeled ADSCs sheets can be easily and clearly detectedin vivoand have persisted for at least 12 weeks. Our experiment confirmed USPIO was feasible forin vivolabeling of the ADSCs sheets with the optimal concentration of 50 μg Fe/ml and the tracing time is no less than 12 weeks.
Identification of miRNA-mRNA Modules in Colorectal Cancer Using Rough Hypercuboid Based Supervised Clustering
Authors: Paul Sushmita , Lakatos Petra , Hartmann Arndt , Schneider-Stock Regine , Vera Julio
Published: February 2017

Differences in the expression profiles of miRNAs and mRNAs have been reported in colorectal cancer. Nevertheless, information on important miRNA-mRNA regulatory modules in colorectal cancer is still lacking. In this regard, this study presents an application of the RH-SAC algorithm on miRNA and mRNA expression data for identification of potential miRNA-mRNA modules. First, a set of miRNA rules was generated using the RH-SAC algorithm. The mRNA targets of the selected miRNAs were identified using the miRTarBase database. Next, the expression values of target mRNAs were used to generate mRNA rules using the RH-SAC. Then all miRNA-mRNA rules have been integrated for generating networks. The RH-SAC algorithm unlike other existing methods selects a group of co-expressed miRNAs and mRNAs that are also differentially expressed. In total 17 miRNAs and 141 mRNAs were selected. The enrichment analysis of selected mRNAs revealed that our method selected mRNAs that are significantly associated with colorectal cancer. We identified novel miRNA/mRNA interactions in colorectal cancer. Through experiment, we could confirm that one of our discovered miRNAs, hsa-miR-93-5p, was significantly up-regulated in 75.8% CRC in comparison to their corresponding non-tumor samples. It could have the potential to examine colorectal cancer subtype specific unique miRNA/mRNA interactions.
Layer-by-Layer Insight into Electrostatic Charge Distribution of Few-Layer Graphene
Authors: Rokni Hossein , Lu Wei
Published: February 2017

In few-layer graphene (FLG) systems on a dielectric substrate such as SiO2, the addition of each extra layer of graphene can drastically alter their electronic and structural properties. Here, we map the charge distribution among the individual layers of finite-size FLG systems using a novel spatial discrete model that describes both electrostatic interlayer screening and fringe field effects. Our results reveal that the charge density in the region very close to the edges is screened out an order of magnitude more weakly than that across the central region of the layers. Our discrete model suggests that the interlayer charge screening length in 1–8 layer thick graphene systems depends mostly on the overall gate/molecular doping level rather than on temperature, in particular at an induced charge density >5 × 1012 cm−2, and can reliably be determined to be larger than half the interlayer spacing but shorter than the bilayer thickness. Our model can be used for designing FLG-based devices, and offers a simple rule regarding the charge distribution in FLG: approximately 70%, 20%, 6% and 3% (99% overall) of the total induced charge density reside within the four innermost layers, implying that the gate-induced electric field is not definitely felt by >4th layer.
Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8+ T cells
Authors: Sun Michael , Ha Ngoc , Pham Duc-Hung , Frederick Megan , Sharma Bandana , Naruse Chie , Asano Masahide , Pipkin Matthew E. , George Rani E. , Thai To-Ha
Published: February 2017

Cbx3/HP1γ is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8+ T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In tumors obtained from Cbx3/HP1γ-insufficient mice or wild type mice treated with Cbx3/HP1γ-insufficient CD8+ T cells, there is an increase of CD8+ effector T cells expressing the stimulatory receptor Klrk1/NKG2D, a decrease in CD4+ CD25+ FOXP3+ regulatory T cells (Treg cells) as well as CD25+ CD4+ T cells expressing the inhibitory receptor CTLA4. Together these changes in the tumor immune environment may have mitigated tumor burden in Cbx3/HP1γ-insufficient mice or wild type mice treated with Cbx3/HP1γ-insufficient CD8+ T cells. These findings suggest that targeting Cbx3/HP1γ can represent a rational therapeutic approach to control growth of solid tumors.
Siliceous spicules in a vauxiid sponge (Demospongia) from the Kaili Biota(Cambrian Stage 5), Guizhou, South China
Authors: Yang X.-L. , Zhao Y.-L. , Babcock L. E. , Peng J.
Published: February 2017

Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and Raman spectroscopy analysis indicate the presence of silica in the skeletal elements of these fossils, suggesting that this taxon possessed a skeleton comprised of spicules. This is the first confirmation of siliceous skeletal elements in fossils of the family Vauxiidae, and it lends support to the hypothesis that some early demosponges possessed biomineralized siliceous skeletons, which were subsequently lost and replaced by spongin later in the evolutionary history of this lineage. The new materials provide critical insight into the phylogeny and evolution of biomineralization in the Demosopongiae.
Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current
Authors: Cheng Jianding , Kyle John W. , Wiedmeyer Brandi , Lang Di , Vaidyanathan Ravi , Makielski Jonathan C.
Published: February 2017

Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to the appearance of cardiomyopathy. We hypothesized VCL mutations underlie risk for SUNDS. A rare heterozygous variant VCL-M94I was found in a SUNDS victim who suffered sudden nocturnal tachypnea and lacked pathogenic variants in known arrhythmia-causing genes. VCL was identified to interact with SCN5A in vitro/vivo. The VCL-M94I was co-expressed with the cardiac sodium channel in HEK293 cells and also overexpressed in induced pluripotent stem cells derived cardiomyocytes (iPSCs-CM). In HEK293 cells with pH 7.4, VCL-M94I caused ~30% decrease in peak sodium current (INa) amplitude compared to WT; under acidotic conditions (pH 7.0) typically found with hypoxia during sleep apnea, M94I resulted in 37% reduction in peak INa compared to WT and the combination of VCL-M94I and pH 7.0 decreased peak INa by ~56% compared to WT at pH 7.4. In iPSCs-CM, similar effects of M94I on reduction of peak INa were observed. This study initially shows both physical and functional interaction between VCL and cardiac sodium channel, and suggests an important role for respiratory acidosis in triggering the fatal arrhythmia underlying SUNDS.
Coupling effect of nodes popularity and similarity on social network persistence
Authors: Jin Xiaogang , Jin Cheng , Huang Jiaxuan , Min Yong
Published: February 2017

Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in social networks, the network structure is growing with the cascading inactivity of existed individuals. Here, we address this challenge through analysis for nodes under a coevolution model, which characterizes individual activity changes under three network growth modes: following the descending order of nodes’ popularity, similarity or uniform random. We show that when nodes possess high spontaneous activities, a popularity-first growth mode obtains highly persistent networks; otherwise, with low spontaneous activities, a similarity-first mode does better. Moreover, a compound growth mode, with the consecutive joining of similar nodes in a short period and mixing a few high popularity nodes, obtains the highest persistence. Therefore, nodes similarity is essential for persistent social networks, while properly coupling popularity with similarity further optimizes the persistence. This demonstrates the evolution of nodes activity not only depends on network topology, but also their connective typology.
Extending calibration-free force measurements to optically-trapped rod-shaped samples
Authors: Català Frederic , Marsà Ferran , Montes-Usategui Mario , Farré Arnau , Martín-Badosa Estela
Published: February 2017

Optical trapping has become an optimal choice for biological research at the microscale due to its non-invasive performance and accessibility for quantitative studies, especially on the forces involved in biological processes. However, reliable force measurements depend on the calibration of the optical traps, which is different for each experiment and hence requires high control of the local variables, especially of the trapped object geometry. Many biological samples have an elongated, rod-like shape, such as chromosomes, intracellular organelles (e.g., peroxisomes), membrane tubules, certain microalgae, and a wide variety of bacteria and parasites. This type of samples often requires several optical traps to stabilize and orient them in the correct spatial direction, making it more difficult to determine the total force applied. Here, we manipulate glass microcylinders with holographic optical tweezers and show the accurate measurement of drag forces by calibration-free direct detection of beam momentum. The agreement between our results and slender-body hydrodynamic theoretical calculations indicates potential for this force-sensing method in studying protracted, rod-shaped specimens.
Atom-Based Sensing of Weak Radio Frequency Electric Fields Using Homodyne Readout
Authors: Kumar Santosh , Fan Haoquan , Kübler Harald , Sheng Jiteng , Shaffer James P.
Published: February 2017

We utilize a homodyne detection technique to achieve a new sensitivity limit for atom-based, absolute radio-frequency electric field sensing of 5 μV cm−1 Hz−1/2. A Mach-Zehnder interferometer is used for the homodyne detection. With the increased sensitivity, we investigate the dominant dephasing mechanisms that affect the performance of the sensor. In particular, we present data on power broadening, collisional broadening and transit time broadening. Our results are compared to density matrix calculations. We show that photon shot noise in the signal readout is currently a limiting factor. We suggest that new approaches with superior readout with respect to photon shot noise are needed to increase the sensitivity further.
Floating of the lobes of mosquito (Aedes togoi) larva for respiration
Authors: Lee Seung Chul , Kim Jun Ho , Lee Sang Joon
Published: February 2017

Mosquito (Aedes togoi) larva has to float its siphon on the water surface to breathe air. To elucidate the floating mechanism of the siphon, morphological structures, especially the flap-like lobes and spiracle of the siphon, were observed. Wettability and dynamic behavior of the lobes on the water surface were also experimentally examined. The lobes formed a hollow cone shape under water and expanded on the water surface. The spiracle was located at the base of the cone. The lobes exhibited hydrophobic wettability. During floating process, the lobes were spread into a triangular shape in apical view, and the spiracle was exposed to air. When they were submerged in water, the lobes were folded into a cone shape to seal the spiracle and protect it from water penetration. These dynamic processes occurred at the water surface. In this study, the floating mechanism of the lobes for respiration was described based on the cross-sectional morphology of the lobes with the pressure induced by surface tension and the hydrostatic pressure proportional to depth. This study would be helpful in elucidating the behavior of mosquito larvae near the water surface and may facilitate the formulation of methods to control mosquito larvae.
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome
Authors: Bando Hironori , Iguchi Genzo , Okimura Yasuhiko , Odake Yukiko , Yoshida Kenichi , Matsumoto Ryusaku , Suda Kentaro , Nishizawa Hitoshi , Fukuoka Hidenori , Mokubo Atsuko , Tojo Katsuyoshi , Maniwa Yoshimasa , Ogawa Wataru , Takahashi Yutaka
Published: February 2017

Anti-PIT-1 antibody syndrome has recently been reported and characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with autoimmunity to a pituitary specific transcription factor PIT-1, which plays an essential role in GH-, PRL-, and TSH-producing cells. Although circulating anti-PIT-1 antibody and PIT-1-reactive cytotoxic T cells (CTLs) were detected in the patients, the pathophysiology and precise mechanisms for the autoimmunity remain unclarified. During the follow up, thymoma was diagnosed in all 3 cases with anti-PIT-1 antibody syndrome. Immunohistochemical analysis revealed that PIT-1 was strongly expressed in neoplastic cortical thymic epithelial cells. Importantly, after thymectomy, the titer of anti-PIT-1 antibody decreased and reactivity of CTLs toward PIT-1 diminished. These data strongly suggest that the aberrant expression of PIT-1 in the thymoma plays a causal role in the development of this syndrome. Thus, we define that this syndrome is a novel thymoma-associated autoimmune disease.
A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
Authors: Rockwood K. , Blodgett J. M. , Theou O. , Sun M. H. , Feridooni H. A. , Mitnitski A. , Rose R. A. , Godin J. , Gregson E. , Howlett S. E.
Published: February 2017

Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measuring variability in health in animals of the same age. In humans, this variability has been quantified by counting age-related health deficits in a frailty index. Here we show the results of extending that approach to mice. Across the life course, many important features of deficit accumulation are present in both species. These include gradual rates of deficit accumulation (slope = 0.029 in humans; 0.036 in mice), a submaximal limit (0.54 in humans; 0.44 in mice), and a strong relationship to mortality (1.05 [1.04–1.05] in humans; 1.15 [1.12–1.18] in mice). Quantifying deficit accumulation in individual mice provides a powerful new tool that can facilitate translation of research on ageing, including in relation to disease.
Enhancement of Local Photovoltaic Current at Ferroelectric Domain Walls in BiFeO3
Authors: Yang Ming-Min , Bhatnagar Akash , Luo Zheng-Dong , Alexe Marin
Published: February 2017

Domain walls, which are intrinsically two dimensional nano-objects exhibiting nontrivial electronic and magnetic behaviours, have been proven to play a crucial role in photovoltaic properties of ferroelectrics. Despite this recognition, the electronic properties of domain walls under illumination until now have been accessible only to macroscopic studies and their effects upon the conduction of photovoltaic current still remain elusive. The lack of understanding hinders the developing of nanoscale devices based on ferroelectric domain walls. Here, we directly characterize the local photovoltaic and photoconductive properties of 71° domain walls on BiFeO3 thin films with a nanoscale resolution. Local photovoltaic current, proven to be driven by the bulk photovoltaic effect, has been probed over the whole illuminated surface by using a specially designed photoelectric atomic force microscopy and found to be significantly enhanced at domain walls. Additionally, spatially resolved photoconductive current distribution reveals a higher density of excited carriers at domain walls in comparison with domains. Our measurements demonstrate that domain wall enhanced photovoltaic current originates from its high conduction rather than the internal electric field. This photoconduction facilitated local photovoltaic current is likely to be a universal property of topological defects in ferroelectric semiconductors.
Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies
Authors: Zhang Tie-Ning , Gao Shan-Yan , Shen Zi-Qi , Li Da , Liu Cai-Xia , Lv Hai-Chen , Zhang Yuan , Gong Ting-Ting , Xu Xin , Ji Chao , Wu Qi-Jun
Published: February 2017

The relationship between selective serotonin-reuptake inhibitors (SSRIs) use during first trimester and cardiovascular-related malformations of infants is still uncertain. Therefore, we conducted this systematic review and meta-analysis to assess the aforementioned association. A systematic literature review identified studies for cohort studies about SSRIs use and cardiovascular-related malformations in PubMed and Web of Science. We summarized relative risk (RRs) and 95% confidence intervals (CIs) of cardiovascular-related malformations using random-effects model, and heterogeneity and publication-bias analyses were conducted. Eighteen studies met the inclusion criteria. Pregnant women who were exposed to SSRIs at any point during the first trimester had a statistically significant increased risk of infant cardiovascular-related malformations (RR = 1.26, 95%CI = 1.13–1.39), with moderate heterogeneity (I2 = 53.6). The corresponding RR of atrial septal defects (ASD), ventricular septal defects (VSD), ASD and/or VSD was 2.06 (95%CI = 1.40–3.03, I2 = 57.8), 1.15 (95%CI = 0.97–1.36; I2 = 30.3), and 1.27 (95%CI = 1.14–1.42; I2 = 40.0), respectively. No evidence of publication bias and significant heterogeneity between subgroups was detected by meta-regression analyses. In conclusion, SSRIs use of pregnant women during first trimester is associated with an increased risk of cardiovascular-related malformations of infants including septal defects. The safety of SSRIs use during first trimester should be discussed to pregnant women with depression.
Theory of topological insulator waveguides: polarization control and the enhancement of the magneto-electric effect
Authors: Crosse J. A.
Published: February 2017

Topological insulators subject to a time-reversal-symmetry-breaking perturbation are predicted to display a magneto-electric effect that causes the electric and magnetic induction fields to mix at the material’s surface. This effect induces polarization rotations of between ≈1–10 mrad per interface in an incident plane-polarized electromagnetic wave normal to a multilayered structure. Here we show, theoretically and numerically, that by using a waveguide geometry with a topological insulator guide layer and magneto-dielectric cladding it is possible to achieve rotations of ≈100 mrad and generate an elliptical polarization with only a three-layered structure. This geometry is beneficial, not only as a way to enhance the magneto-electric effect, rendering it easier to observe, but also as a method for controlling the polarization of electromagnetic radiation.
Uniformly Dispersed ZnFe2O4 Nanoparticles on Nitrogen-Modified Graphene for High-Performance Supercapacitor as Electrode
Authors: Li Lei , Bi Huiting , Gai Shili , He Fei , Gao Peng , Dai Yunlu , Zhang Xitian , Yang Dan , Zhang Milin , Yang Piaoping
Published: February 2017

A facile strategy has been adopted for the preparation of ZnFe2O4/NRG composite by anchoring ultrasmall ZnFe2O4 nanoparticles on nitrogen-doped reduced graphene (denoted as NRG) for high-performance supercapacitor electrode. Remarkably, the growth of ZnFe2O4 nanocrystals, the reduction of graphitic oxide and the doping of nitrogen to graphene have been simultaneously achieved in one process. It is found that the NRG employed as substrate can not only control the formation of nano-sized ZnFe2O4, but also guarantee the high dispersion without any agglomeration. Benefiting from this novel combination and construction, the hybrid material has large surface area which can provide high exposure of active sites for easy access of electrolyte and fast electron transport. When served as supercapacitor electrode, the ZnFe2O4/NRG composite exhibits a favorable specific capacitance of 244 F/g at 0.5 A/g within the potential range from −1 to 0 V, desirable rate stability (retain 131.5 F/g at 10 A/g) and an admirable cycling durability of 83.8% at a scan rate of 100 mV/s after 5000 cycles. When employed as symmetric supercapacitor, the device demonstrates favorable performance. These satisfactory properties of the ZnFe2O4/NRG composite can make it be of great promise in the supercapacitor application.
Application of carbohydrate arrays coupled with mass spectrometry to detect activity of plant-polysaccharide degradative enzymes from the fungus Aspergillus niger
Authors: van Munster Jolanda M. , Thomas Baptiste , Riese Michel , Davis Adrienne L. , Gray Christopher J. , Archer David B. , Flitsch Sabine L.
Published: February 2017

Renewables-based biotechnology depends on enzymes to degrade plant lignocellulose to simple sugars that are converted to fuels or high-value products. Identification and characterization of such lignocellulose degradative enzymes could be fast-tracked by availability of an enzyme activity measurement method that is fast, label-free, uses minimal resources and allows direct identification of generated products. We developed such a method by applying carbohydrate arrays coupled with MALDI-ToF mass spectrometry to identify reaction products of carbohydrate active enzymes (CAZymes) of the filamentous fungus Aspergillus niger. We describe the production and characterization of plant polysaccharide-derived oligosaccharides and their attachment to hydrophobic self-assembling monolayers on a gold target. We verify effectiveness of this array for detecting exo- and endo-acting glycoside hydrolase activity using commercial enzymes, and demonstrate how this platform is suitable for detection of enzyme activity in relevant biological samples, the culture filtrate of A. niger grown on wheat straw. In conclusion, this versatile method is broadly applicable in screening and characterisation of activity of CAZymes, such as fungal enzymes for plant lignocellulose degradation with relevance to biotechnological applications as biofuel production, the food and animal feed industry.
Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations
Authors: Liu C , Bousman C A , Pantelis C , Skafidas E , Zhang D , Yue W , Everall I P
Published: February 2017

Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousands of alleles associated with increased liability for the disorder. However, the generalizability of any one allelic marker of liability is remarkably low and has bred the notion that schizophrenia may be better conceptualized as a pathway(s) disorder. Here, we empirically tested this notion by conducting a pathway-wide association study (PWAS) encompassing 255 experimentally validated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways among 5033 individuals diagnosed with schizophrenia and 5332 unrelated healthy controls across three distinct ethnic populations; European-American (EA), African-American (AA) and Han Chinese (CH). We identified 103, 74 and 87 pathways associated with schizophrenia liability in the EA, CH and AA populations, respectively. About half of these pathways were uniquely associated with schizophrenia liability in each of the three populations. Five pathways (serotonergic synapse, ubiquitin mediated proteolysis, hedgehog signaling, adipocytokine signaling and renin secretion) were shared across all three populations and the single-nucleotide polymorphism sets representing these five pathways were enriched for single-nucleotide polymorphisms with regulatory function. Our findings provide empirical support for schizophrenia as a pathway disorder and suggest schizophrenia is not only a polygenic but likely also a poly-pathway disorder characterized by both genetic and pathway heterogeneity.
Novel1H NMR relaxometry methods to study the proton distribution and water migration properties of tobacco
Authors: Zheng Songjin , Li Teng , Li Yuan , Shi Qunyan , Wu Fei
Published: February 2017

The water and oil distribution in tobacco has a significant impact on its industrial manufacturing.
Hyperbranched polymer based fluorescent probes for ppt level nerve agent simulant vapor detection
Authors: Jiang Haibo , Wu Pengcheng , Zhang Yu , Jiao Zinuo , Xu Wei , Zhang Xiangtao , Fu Yanyan , He Qingguo , Cao Huimin , Cheng Jiangong
Published: February 2017

A terpyridine end capped hyperbranched polymer for the sensitive detection of sarin mimic diethyl chlorophosphate.
DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription
Authors: MacPherson I. S. , Temme J. S. , Krauss I. J.
Published: February 2017

A method for the physical attachment of folded RNA libraries to their encoding DNA is presented as a way to circumvent the reverse transcription step during systematic evolution of RNA ligands by exponential enrichment (RNA-SELEX).
Substituent and catalyst effects on GAC lactonization of γ-hydroxy esters
Authors: Brenna Elisabetta , Distante Francesco , Gatti Francesco G. , Gatti Giuseppe
Published: February 2017

The effect of catalyst, substituent and leaving group on reactivity was probed experimentally and computationally rationalized.
Bridgehead isomer effects in bis(phosphido)-bridged diiron hexacarbonyl proton reduction electrocatalysts
Authors: Rahaman Ahibur , Gimbert-Suriñach Carolina , Ficks Arne , Ball Graham E. , Bhadbhade Mohan , Haukka Matti , Higham Lee , Nordlander Ebbe , Colbran Stephen B.
Published: February 2017

The influence of the substitution, orientation and structure of the phosphido bridges in [Fe2(CO)6(μ-PR2)2] electrocatalysts of proton reduction has been studied.
Optimizing the binder percentage to reduce matrix effects for the LIBS analysis of carbon in coal
Authors: Yao Shunchun , Zhao Jingbo , Xu Jialong , Lu Zhimin , Lu Jidong
Published: February 2017

Quantitative analysis of elements by laser-induced breakdown spectroscopy (LIBS) is significantly affected by matrix effects in coal.
Chemical communication and dynamics of droplet emulsions in networks of Belousov–Zhabotinsky micro-oscillators produced by microfluidics
Authors: Torbensen Kristian , Rossi Federico , Ristori Sandra , Abou-Hassan Ali
Published: February 2017

This tutorial provides an introduction to the Belousov–Zhabotinsky oscillatory reaction and reviews the role of microfluidics in engineering compartmentalized and dynamical BZ systems.
DNA condensation in live E. coli provides evidence for transertion
Authors: Gorle Anil K. , Bottomley Amy L. , Harry Elizabeth J. , Collins J. Grant , Keene F. Richard , Woodward Clifford E.
Published: February 2017

Fluorescence microscopy has been used to examine the condensation of DNA in live bacteria by a tetranuclear polypyridylruthenium(ii) complex.
Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I
Authors: Krishnathas Robin , Bonke Erik , Dröse Stefan , Zickermann Volker , Nasiri Hamid R.
Published: February 2017

By probing the quinone substrate binding site of mitochondrial complex I with a focused set of quinazoline-based compounds, we identifiedEVP4593as a novel, highly potent and specific inhibitor of mitochondrial complex I.
Divergent synthesis from reactions of 2-trifluoromethyl-1,3-conjugated enynes with N-acetylated 2-aminomalonates
Authors: Yang Jieru , Zhou Xiaofan , Zeng Yu , Huang Chaoqian , Xiao Yuanjing , Zhang Junliang
Published: February 2017

Divergent synthesis of fluorinated heterocycles from the reactions of 2-trifluoromethyl-1,3-conjugated enynes with N-acetylated 2-aminomalonates and subsequent gold-catalysed cyclization were developed.
Effect of graphene oxide interlayer electron-phonon coupling on the electro-optical parameters of a ferroelectric liquid crystal
Authors: Singh D. P. , Kumar V. , Kumar A. , Manohar R. , Pasricha Renu , Duponchel B. , Boussoualem Y. , Sahraoui A. H. , Daoudi A.
Published: February 2017

Electro-optical properties of FLC are cell thickness dependent. Interlayer electron-phonon coupling is responsible for the change in the E-O properties. The FLC–GO composite is suitable for use in UV filters.
Synthesis, characterization and performance of bifunctional catalysts for the synthesis of menthol from citronellal
Authors: Dam J. ten , Ramanathan A. , Djanashvili K. , Kapteijn F. , Hanefeld U.
Published: February 2017

TUD-1 based catalysts containing WO3 and Pt were synthesized and assessed in the conversion of citronellal to menthol. The hydrogenation on Pt is highest for small WO3 particles, while their agglomeration leads to a decreased interaction and catalytic performance.
Electrochemical study on the corrosion behavior of Ti3SiC2 in 3.5% NaCl solution
Authors: Zhu Ming , Wang Rui , Chen Chen , Zhang Haibin , Zhang Guojun
Published: February 2017

The differences between the Ti–C and Ti–Si chemical bonds limit the passivation ability, resulting in a decreased passivation ability.
Silica sub-microspheres induce autophagy in an endocytosis dependent manner
Authors: Huang Dengtong , Zhou Hualu , Gong Xuanqing , Gao Jinhao
Published: February 2017

Silica sub-microparticles, 0.5–0.7 μm in diameter, induce high levels of autophagy due to their suitable size for endocytosis.
Towards understanding of laccase-catalysed oxidative oligomerisation of dimeric lignin model compounds
Authors: Ramalingam B. , Sana B. , Seayad J. , Ghadessy F. J. , Sullivan M. B.
Published: February 2017

The isolation of early intermediates in the laccase-catalysed oligomerisation of lignin model compounds indicated the preferential formation of C5–C5′ over C5–O–C4′ linkages.
Assessment of the toxicity and inflammatory effects of different-sized zinc oxide nanoparticles in 2D and 3D cell cultures
Authors: Wu Zhipan , Guan Rongfa , Tao Miao , Lyu Fei , Cao Guozhou , Liu Mingqi , Gao Jianguo
Published: February 2017

Two-dimensional (2D) monolayer cell cultures are the most common in vitro models for mechanistic studies on the toxicity of engineered nanoparticles (NPs).
Simultaneous fluorescence analysis of the different carbohydrates expressed on living cell surfaces using functionalized quantum dots
Authors: He Dongxiu , Wang Danxia , Shi Xiaoxin , Quan Wenjie , Xiong Runde , Yu Cui-yun , Huang Honglin
Published: February 2017

The aberrant expression of carbohydrates has been associated with the occurrence, growth, progression and metastasis of tumors.
Sequential crystallization of high and low melting waxes to improve oil structuring in wax-based oleogels
Authors: Tavernier Iris , Doan Chi Diem , Van de Walle Davy , Danthine Sabine , Rimaux Tom , Dewettinck Koen
Published: February 2017

The objective of this study was to investigate the combination of a high-melting wax (sunflower wax or rice bran wax) with a low-melting wax (berry wax) on the crystallization and gelation behavior of the corresponding oleogels in rice bran oil (RBO).
Antibacterial and catalytic activities of biosynthesized silver nanoparticles prepared by using an aqueous extract of green coffee bean as a reducing agent
Authors: Wang Mengmeng , Zhang Wenjing , Zheng Xuesong , Zhu Peizhi
Published: February 2017

Spherical biogenic silver nanoparticles (AgNPs) were synthesized using aqueous green coffee bean extract as a reducing agent.
Exploring the catalytic activity of Lewis-acidic uranyl complexes in the nucleophilic acyl substitution of acid anhydrides
Authors: Takao Koichiro , Akashi Shin
Published: February 2017

Uranyl(vi) ion is a strongly hard Lewis-acid and plays a catalytic role in the nucleophilic acyl substitution of acid anhydrides.
Uptake dynamics of graphene quantum dots into primary human blood cells following in vitro exposure
Authors: Fasbender Stefan , Allani Sonja , Wimmenauer Christian , Cadeddu Ron-Patrick , Raba Katharina , Fischer Johannes C. , Bulat Bekir , Luysberg Martina , Seidel Claus A. M. , Heinzel Thomas , Haas Rainer
Published: February 2017

Human leukocytes obtained from samples of leukapheresis products of three healthy donors stimulated by granulocyte colony stimulating factor (G-CSF) were exposed to graphene quantum dots.
Mixed conduction in BaF2 nanocrystals under high pressure
Authors: Cui Xiaoyan , Hu Tingjing , Wang Jingshu , Zhang Junkai , Zhao Rui , Li Xuefei , Yang Jinghai , Gao Chunxiao
Published: February 2017

The charge transport behavior of barium fluoride nanocrystals has been investigated by in situ impedance measurement up to 23 GPa.
Functional organic click-materials: application in phosphorescent organic light emitting diodes
Authors: Kautny Paul , Zhao Chenyang , Kader Thomas , Stöger Berthold , Horkel Ernst , Chen Jiangshan , Ma Dongge , Fröhlich Johannes , Lumpi Daniel
Published: February 2017

1,2,3-Triazole has been applied as a novel linker in donor–acceptor materials to control intramolecular charge transfer phenomena.
Developmental, chemical and transcriptional characteristics of artificially pollinated and hormone-induced parthenocarpic fruits of Siraitia grosvenorii
Authors: Tu Dongping , Luo Zuliang , Wu Bin , Ma Xiaojun , Shi Hongwu , Mo Changming , Huang Jie , Xie Wenjuan
Published: February 2017

Unpollinated ovaries of Siraitia grosvenorii grew parthenocarpically in response to the application of GA3 and CPPU.
Spectroscopic and thermodynamic investigations of clathrate hydrates of methacrolein
Authors: Ahn Yun-Ho , Youn Yeobum , Cha Minjun , Lee Huen
Published: February 2017

This study characterized new structure II (sII) clathrate hydrates, consisting of 136 H2O molecules with 8 large 51264 cages and 16 small 512 cages, with methacrolein for the first time.
Effects of solution treatment and aging on the microstructure, mechanical properties, and corrosion resistance of a β type Ti–Ta–Hf–Zr alloy
Authors: Lin Jixing , Ozan Sertan , Munir Khurram , Wang Kun , Tong Xian , Li Yuncang , Li Guangyu , Wen Cuie
Published: February 2017

A β type TTHZ alloy (Ti–40Ta–22Hf–11.7Zr) experienced various phase transitions during solution and aging treatments, and the different phases of the alloy significantly influenced its mechanical properties and corrosion behaviour.
A protector-free one-pot strategy to synthesize highly dispersed Pd hydrogenation catalysts in a broad loading range on polystyrene
Authors: Le Li-Yun , Ren Ai-Min , Gao Xing-Heng , Zhao Dan , Xie Run-Hong , Zhang Ning
Published: February 2017

Pd nanocatalysts in desired size range (ca. 3.0–5.0 nm) and clean state (protector-free) were feasibly prepared in one-pot system by a surface electrostatic manipulation on polystyrene in broad loading (0.2–4.6 wt%).
Generation of cloned adult muscular pigs with myostatin gene mutation by genetic engineering
Authors: Kang Jin-Dan , Kim Seokjoong , Zhu Hai-Ying , Jin Long , Guo Qing , Li Xiao-Chen , Zhang Yu-Chen , Xing Xiao-Xu , Xuan Mei-Fu , Zhang Guang-Lei , Luo Qi-Rong , Kim Yong Soo , Cui Cheng-Du , Li Wen-Xue , Cui Zheng-Yun , Kim Jin-Soo , Yin Xi-Jun
Published: February 2017

Skeletal muscle is the most economically valuable tissue in meat-producing animals and enhancing muscle growth in these species may enhance the efficiency of meat production.
High performance MWCNT–Pt nanocomposite-based cathode for passive direct methanol fuel cells
Authors: Pu Longjuan , Zou Liangliang , Zhou Yi , Zou Zhiqing , Yang Hui
Published: February 2017

The membrane electrode assembly with MWCNT–Pt nanocomposite-based cathode shows high performance for passive direct methanol fuel cells.
Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors
Authors: Ren Jie , Li Yuhang , Ke Hongwei , Li Yanting , Yang Longhe , Yu Helin , Huang Rui , Lu Canzhong , Qiu Yan
Published: February 2017

Preventing PEA degradation by inhibition of NAAA is a novel strategy for the treatment of inflammation and pain. We reported the discovery of oxazolidone derivative as highly potent NAAA inhibitors, including 2f, 3h, 3i and 3j.
Achieving efficient violet-blue electroluminescence with CIEy<0.06 and EQE >6% from naphthyl-linked phenanthroimidazole–carbazole hybrid fluorophores
Authors: Chen Wen-Cheng , Yuan Yi , Ni Shao-Fei , Tong Qing-Xiao , Wong Fu-Lung , Lee Chun-Sing
Published: February 2017

Naphthyl-linked donor–π–acceptor fluorophores were utilized to achieve high performance and good color purity violet-blue emission in organic light-emitting devices (OLEDs).
Role of carbon defects in the reversible alloying states of red phosphorus composite anodes for efficient sodium ion batteries
Authors: Li Mengya , Carter Rachel , Oakes Landon , Douglas Anna , Muralidharan Nitin , Pint Cary L.
Published: February 2017

Here we report the first mechanistic study investigating the effect of carbon defects on the evolution of different sodium–red phosphorus (red P) alloy states for stable high capacity sodium ion battery anodes.
Towards a stable ion-solvating polymer electrolyte for advanced alkaline water electrolysis
Authors: Aili David , Wright Andrew G. , Kraglund Mikkel Rykær , Jankova Katja , Holdcroft Steven , Jensen Jens Oluf
Published: February 2017

Steric hindrance is employed as a design strategy of polybenzimidazoles for ion-solvating polymer electrolyte membrane alkaline water electrolysis.
Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials
Authors: Chen Yi-Xuan , Zhu Rong , Xu Zheng-liang , Ke Qin-Fei , Zhang Chang-Qing , Guo Ya-Ping
Published: February 2017

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.
A biomaterial approach to cell reprogramming and differentiation
Authors: Long Joseph , Kim Hyejin , Kim Dajeong , Lee Jong Bum , Kim Deok-Ho
Published: February 2017

Improving cell reprogramming methods is vital to regenerative medicine efforts. This review discusses advances in reprogramming using biomaterial based approaches.
Click-based functionalization of a 2′-O-propargyl-modified branched DNA nanostructure
Authors: Valsangkar Vibhav , Chandrasekaran Arun Richard , Wang Rui , Haruehanroengra Phensinee , Levchenko Oksana , Halvorsen Ken , Sheng Jia
Published: February 2017

We report a click-based strategy to incorporate a metal chelating (bipyridine) ligand and a fluorescent tag (FAM) into a three-point-star DNA tile containing 2′-O-propargyl groups.
A versatile strategy for fabricating various Cu2ZnSnS4 precursor solutions
Authors: Liu Kaisi , Yao Bin , Li Yongfeng , Ding Zhanhui , Sun Hao , Jiang Yuhong , Wang Gang , Pan Daocheng
Published: February 2017

Herein, we successfully prepared dithiocarbamate-based Cu2ZnSnS4 (CZTS) precursor solutions using various amino groups such as methylamine, ethylamine, propylamine, butylamine, amylamine, hexylamine, octylamine, and ethanolamine.
Novel benzo[c][1,2,5]oxadiazole-naphthalenediimide based copolymer for high-performance air-stable n-type field-effect transistors exhibiting high electron mobility of 2.43 cm2 V−1 s−1
Authors: Zhao Zhiyuan , Yin Zhihong , Chen Huajie , Guo Yunlong , Tang Qinxin , Liu Yunqi
Published: February 2017

A copolymer (PNBO) containing benzo[c][1,2,5]oxadiazole and naphthalenediimide acceptors was developed for high-performance air-stable n-type field-effect transistors with a mobility of 2.43 cm2 V−1 s−1.
A magnetic resonance disruption (MaRDi) technique for the detection of surface immobilised magnetic nanoparticles
Authors: Parslow S. T. , Hughes-Riley T. , Newton M. I. , Morris R. H.
Published: February 2017

The relative quantity of surface bound magnetic nanoparticles can be determined by measuring how much the signal measured from a suitable liquid covering the surface is disrupted.
Dopamine-assisted fixation of drug-loaded polymeric multilayers to osteoarticular implants for tuberculosis therapy
Authors: Li Dan , Li Litao , Ma Yunlong , Zhuang Yaping , Li Dawei , Shen Hong , Wang Xing , Yang Fei , Ma Yuanzheng , Wu Decheng
Published: February 2017

Isoniazid could release from the polymeric multilayers covalently fixed to smooth Ti surfaces for over 8 weeks in vivo.
The screened pseudo-charge repulsive potential in perturbed orbitals for band calculations by DFT+U
Authors: Huang Bolong
Published: February 2017

The dependence of screening behavior on the occupation response qI is illustrated, and the corresponding potential variation of the pseudo-charge is shown in both two-dimensional (left-panel) and three-dimensional (right-panel) forms.
An efficient route to fabricate fatigue-free P(VDF-TrFE) capacitors with enhanced piezoelectric and ferroelectric properties and excellent thermal stability for sensing and memory applications
Authors: Singh Deepa , Deepak Deepak , Garg Ashish
Published: February 2017

P(VDF-TrFE), the best known ferroelectric polymer, suffers from a rather low piezoelectric response as well as poor electrical fatigue life, hampering its application potential.
Cobalt nanoparticles embedded in a porous carbon matrix as an efficient catalyst for ammonia decomposition
Authors: Li Lei , Jiang Ruiyu , Chu Wei , Cang Hui , Chen Huawei , Yan Jinlong
Published: February 2017

A metallic Co nanoparticle catalyst embedded in a carbon matrix catalyst was synthesized through a facile solvothermal method and subsequent thermal treatment.
Lanthanide derivatives of Ta/W mixed-addendum POMs as proton-conducting materials
Authors: Peng Qingpo , Li Shujun , Wang Ruoya , Liu Shuxia , Xie Linhua , Zhai Jianxin , Zhang Jie , Zhao Qianyi , Chen Xuenian
Published: February 2017

Four lanthanide derivatives were isolated by the self-assembly of {P2W15Ta3O62} and lanthanide ions, which showed good proton conduction performance.
Switching the electromagnetic properties of multicomponent porous carbon materials derived from bimetallic metal–organic frameworks: effect of composition
Authors: Liu Wei , Pan Junjie , Ji Guangbin , Liang Xiaohui , Cheng Yan , Quan Bin , Du Youwei
Published: February 2017

A series of BMZIFs were converted to multicomponent carbon composites with designed complex structures and tunable electromagnetic properties.
Slow magnetic relaxation in a Co(ii) octahedral–tetrahedral system formed of a [CoL3]2+ core with L = bis(diphenylphosphanoxido) methane and tetrahedral [CoBr4]2− counter anions
Authors: Varga F. , Rajnák C. , Titiš J. , Moncoľ J. , Boča R.
Published: February 2017

A bimetallic Co(ii) compound [Co(dppmO,O)3][CoBr4] consisting of cationic octahedral and anionic tetrahedral units shows a sizable magnetic anisotropy and field-supported slow magnetic relaxation with the relaxation time τ = 0.1–0.3 s at T = 1.9 K.
Reversible luminescent colour changes of mononuclear copper(i) complexes based on ligand exchange reactions by N-heteroaromatic vapours
Authors: Ohara Hiroki , Ogawa Tomohiro , Yoshida Masaki , Kobayashi Atsushi , Kato Masako
Published: February 2017

A highly blue-luminescent mononuclear copper(i) complex showed a reversible emission colour change ranging from blue-green to red by vapour exposure of N-heteroaromatics due to a ligand exchange reaction.
An efficient Sn(ii)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework
Authors: Chavan Santosh S. , Supekar Mrudul V. , Burate Pralhad A. , Rupanwar Bapurao D. , Shelke Anil M. , Suryavanshi Gurunath
Published: February 2017

A novel Sn(ii)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields.
Self-healable, tough and highly stretchable hydrophobic association/ionic dual physically cross-linked hydrogels
Authors: Zhang Yulin , Hu Chengxin , Xiang Xu , Diao Yongfu , Li Binwei , Shi Linying , Ran Rong
Published: February 2017

In this work, we describe a novel method for the production of tough and highly stretchable hydrogels with self-healing behavior, tensile strength of 150–300 kPa and stretch at break of 2400–2800%.
A coiled-coil strategy for the directional display of multiple proteins on the surface of iron oxide nanoparticles
Authors: Hill Brandon J. , Xu Yaolin , Sherwood Jennifer , Raddatz Andrew D. , Kim Yonghyun , Bao Yuping , Duffy Carol
Published: February 2017

Utilization of a coiled-coil strategy for the display of multiple proteins on nanoparticles under physiological conditions.
Further insight into the photochemical behavior of 3-aryl-N-(arylsulfonyl)propiolamides: tunable synthetic route to phenanthrenes
Authors: Chen Ming , Zhao Xinxin , Yang Chao , Wang Yanpei , Xia Wujiong
Published: February 2017

Reported herein is further insight into the photochemical behaviour of 3-aryl-N-(arylsulfonyl)-propiolamides, which provides a straightforward way to access meaningful phenanthrenes.
Electrospun nanofiber membranes as ultrathin flexible supercapacitors
Authors: Chee W. K. , Lim H. N. , Zainal Z. , Harrison I. , Huang N. M. , Andou Y. , Chong K. F. , Pandikumar A.
Published: February 2017

A highly flexible electrochemical supercapacitor electrode was developed with a novel metal oxide-reinforced nanofiber electrode by utilizing a solution-based electrospinning technique.
Franck–Condon simulation for unraveling vibronic origin in solvent enhanced absorption and fluorescence spectra of rubrene
Authors: Hu Ying , Wang Chen-Wen , Zhu Chaoyuan , Gu Fenglong , Lin Sheng-Hsien
Published: February 2017

The damped FC method shows how and which local modes are responsible to solvent enhance vibronic spectra.
Composition-controlled synthesis and tunable optical properties of ternary boron carbonitride nanotubes
Authors: Li Hongling , Tay Roland Yingjie , Tsang Siu Hon , Jing Lin , Zhu Minmin , Leong Fei Ni , Teo Edwin Hang Tong
Published: February 2017

Ternary boron nitride nanotubes (BCNNTs) with controllable compositions and tunable optical band gaps have been successfully achieved.
Cellulose/SnS2 composite with enhanced visible-light photocatalytic activity prepared by microwave-assisted ionic liquid method
Authors: Lin Chunxiang , Zhu Moshuqi , Zhang Teng , Liu Yifan , Lv Yuancai , Li Xiaojuan , Liu Minghua
Published: February 2017

IL type influences the morphology of SnS2 prepared by MAIL methods. Cellulose support enhances the performance of as-synthesized CE/SnS2 composite.