bluuebunny/crossref_metadata_2025 huggingface dataset:
The electrochemical performance of perovskite LaMnO3
Authors: Palayyan Raja Bai Paulcy Rani , Sarojam Sivakala , Salimkumar Shailaja Anju Krishna , Mini Aravind Anu , Suryabai Xavier Thankappan
Published: July 2024

Perovskite oxides have attracted as promising electrode materials for supercapacitors because of their unique structure, compositional flexibility, and inherent oxygen vacancy. In the present work, LaMnO3(LMO) perovskites are synthesised by microwave assisted chemical coprecipitation and followed by calcination at 750 ˚  C. The crystal structure and the presence of functional groups in LaMnO3 were studied through X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The surface morphology was characterized by field emission scanning electron microscopy (FESEM). Electrochemical performance of LMO electrodes is evaluated in 3M KOH and 3M NaOH electrolytes. The specific capacitance of the LMO electrode in 3M NaOH and 3M KOH electrolyte were calculated to be 557.76 F/g and 290.63 F/g at scan rate of 5mV/s. The enhancement in the specific capacitance of the LMO electrode in 3M NaOH can be attributed to the effective charge storage mechanism.
“Now there is a lot of business in the museum”: letters from I. A. Vinogradov to S. F. Platonov (1925–1930)
Authors: Mitrofanov V. V. ,   University under the Interparliamentary Assembly of EURASEC
Published: July 2024

The epistolary materials of the outstanding Tver local historian and museum figure I. A. Vinogradov during the last years of his communication with academician S. F. Platonov are introduced into scientific circulation. Many mutual acquaintances are mentioned - famous scientists, lovers of local history. Since 1926, interesting facts related to the name of A.S. Pushkin have been reported. The development of the museum, the growth of its collections, the return to Tver of many artistic treasures from other institutions are important evidence of the fruitful activity of I. A. Vinogradov. The arrest, trial and administrative exile to Novgorod came as a complete surprise to those around him. Torn away from his beloved work in the Tver museum, even in new conditions he looked for opportunities to be useful and serve the interests of culture, which he succeeded in, although not to the fullest. The museum theme, along with others, remains the main one. Among the new ones is the situation of the archives in Novgorod, their destruction and the loss of many valuable documents. Relations with the academician remain active and humanly kind.
Exploring electron ptychography for low dose imaging
Authors:   , Gao Chuang
Published: July 2024

Transmission electron microscopy is an important technique in the exploration of materials’ structures. This is especially true since the development of electron optical aberration correctors greatly facilitated atomic resolution imaging. We are currently experiencing an ongoing revolution in electron microscopy with the widespread adoption of direct electron detectors. Scientists have reported a lot of key scientific findings facilitated by direct electron detectors. One particular research domain is electron ptychography, which holds promise for unraveling the intricate structures of highly beam-sensitive materials like bio samples and achieving super-resolution without the limitation of aperture in the condenser lens system. Nevertheless, challenges persist both in experimental setups and algorithmic processes. Issues such as the comparatively sluggish scanning speed of cameras and contrast reversals of the reconstructed phase for relatively thick specimens, disrupting phase or weak phase approximations, remain noteworthy limitations. This thesis addresses these challenges by the event-driven Timepix3 detector, presenting a viable solution to the speed bottleneck. Moreover, innovative approaches for applying electron ptychography to relatively thick samples, employing a middle focusing strategy, are proposed. This research aims to push the boundaries of electron microscopy, offering solutions to existing limitations and advancing the field towards more efficient and accurate imaging techniques.
Molecular imaging for early response assessment of neo-adjuvant chemotherapy and drugs targeting the PI3K/Akt/mTOR pathway in HER-2 amplified breast cancer
Authors:   , Dockx Yanina
Published: July 2024

Neoadjuvant chemotherapy (NACT) is a well-established, safe, and effective treatment for breast cancer, offering benefits like increased rates of breast-conserving surgery and early evaluation of therapy effectiveness. Combining NACT with the anti-HER-2 antibody trastuzumab improves survival in patients with HER-2 overexpressing breast cancer. However, only a minority of these patients respond to trastuzumab, with relapse often linked to drug resistance through the PI3K/Akt/mTOR pathway. This resistance suggests that combining trastuzumab with PI3K inhibitors might improve outcomes. Early identification of non-responders could allow for timely modification of treatment strategies, but currently, there are no clinical biomarkers to predict or monitor response to PI3K/Akt/mTOR-targeted drugs. Imaging modalities like PET scans, which assess tumor glucose metabolism using [18F]FDG, provide a comprehensive view of the tumor burden. However, it's unclear if [18F]FDG PET effectively indicates cell kill. An alternative tracer, [18F]FLT, which focuses on cell proliferation, might offer a better indication of response, although its efficacy in HER-2 positive breast cancer remains uncertain. In comparative studies of [18F]FDG and [18F]FLT uptake in HER-2 overexpressing breast cancer cell lines treated with trastuzumab and PI3K/Akt/mTOR inhibitors, [18F]FDG uptake reductions were not evident before cell kill, while [18F]FLT PET showed earlier response reflections. Nonetheless, [18F]FLT uptake had temporary increases, or metabolic flares, potentially affecting assessment accuracy. Further studies on HER-2 overexpressing tumor xenografts treated with PI3K/Akt/mTOR inhibitors confirmed that [18F]FDG uptake correlated with tumor volume, validating [18F]FDG PET as an early response biomarker. However, treatment responses might be underestimated due to early metabolic flares. A clinical study evaluated the role of [18F]FDG PET as a biomarker of response to combined chemotherapy and targeted therapies in HER-2 overexpressing breast cancer. The study found that tumor metabolic response after six weeks of NACT, assessed with [18F]FDG, was an early predictor of response. The metabolic flare seen in preclinical data was not observed clinically, likely due to the timing of the PET scan. In summary, the timing of PET scans is critical for accurate assessment. Scanning too early can result in false positives due to metabolic flares, while delayed scanning can hinder the effectiveness of tailored therapies. Properly timed [18F]FDG PET scans are essential for predicting treatment response in HER-2 overexpressing breast cancer.
Technological breakthroughs towards motion-robust super-resolution quantitative magnetic resonance imaging for improved detection of brain diseases
Authors:   , Beirinckx Quinten
Published: July 2024

Magnetic resonance imaging (MRI) is one of the most widely used neuroimaging techniques, thanks to its exceptional soft tissue contrast and intrinsic safety for patients. Unfortunately, signal intensities in conventional MRI images are expressed in relative units that depend on scanner hardware and software. While this poses no issue for visual inspection of anatomy, it complicates the quantitative comparison of signal intensities within a scan, between successive scans, and among different subjects. In contrast, quantitative MRI (qMRI) generates quantitative maps of absolute biophysical tissue parameters by voxel-wise fitting a biophysical signal model to a series of contrast-weighted scans. Increasing evidence suggests that qMRI can detect and quantify subtle microscopic tissue damage, aiding in the early detection and accurate diagnosis of various neurodegenerative diseases such as Alzheimer's or multiple sclerosis. The impact of these diseases is growing in our rapidly aging society. However, current qMRI techniques require long scan times due to the need for multiple contrast-weighted scans with high-resolution and high signal-to-noise ratio (SNR). Long scan times increase the risk of motion artifacts, reduce patient throughput, and decrease patient comfort, hindering the clinical adoption of qMRI. This work therefore investigates the use of model-based super-resolution reconstruction (SRR) for qMRI, aiming to optimize the trade-off between spatial resolution, SNR, and scan time. SRR enables the reconstruction of a high-resolution scan or parameter map from a series of low-resolution MRI scans, with typically shorter scan time per image. As an additional innovation in this thesis, patient movement is jointly estimated, which is crucial to avoid motion artifacts in the reconstruction. The new SRR framework is extensively tested and compared with existing SRR methods, both in computer simulations and using real brain MRI data. Furthermore, the new framework uses Bayesian statistics to incorporate prior knowledge about noise and brain tissue characteristics into the reconstruction process. This allows for the reconstruction of a 3D high-resolution quantitative tissue parameter map from motion-affected low-resolution MRI scans. Application to real brain MRI shows that the proposed framework significantly improves the accuracy of tissue parameter quantification compared to methods with a separate motion correction step. Finally, the SRR framework is extended to perfusion MRI for improved quantification of cerebral blood flow (CBF), in combination with Arterial Spin Labeling (ASL). As a result, a high-resolution quantitative CBF parameter map can be directly reconstructed from low-resolution ASL MRI scans, significantly improving SNR and CBF accuracy over traditional ASL methods.
A gestão pedagógica das escolas multisseriadas do município de quixabeira
Authors: Castro Éden Santos de
Published: July 2024

Este trabalho apresenta uma análise sobre o processo das ações pedagógicas realizadas com as escolas multisseriadas do município de Quixabeira – BA no período de 2010 a 2012 e pretendeu refletir sobre a contribuição do Programa Saberes do Campo para a gestão pedagógica das escolas multisseriadas do município de Quixabeira e descrever as ações pedagógicas do Programa Saberes do Campo para as escolas multisseriadas do município de Quixabeira. O mesmo consta de uma reflexão teórica inicial sobre Educação do Campo, classe multisseriada, bem como de uma descrição da realização dos módulos do Programa Escola Ativa, apresentando também o resultado da iniciativa municipal em dar continuidade às ações de formação continuada para professores do campo, após o encerramento do Programa Escola Ativa, com a criação do Programa Saberes do Campo que, através de um curso de formação presencial e em módulos, visou promover formação dos professores das classes multisseriadas para atuarem como formadores de alunos- pesquisadores, oportunizando o acesso introdutório à pesquisa e à ciência, ao mesmo tempo em que valorizando os saberes locais e globais historicamente construídos pelos indivíduos, pelas comunidades e pela humanidade.
A importância dos jogos matemáticos no processo de aprendizagem na educação infantil
Authors: Neto Paulo Byron Oliveira Soares
Published: July 2024

O presente trabalho tem por objetivo apresentar ao leitor a utilidade da psicopedagogia na educação infantil, no que tange o ensino da matemática, com o intuito de tornar o aluno protagonista da sua educação. Destarte, utilizaremos os jogos matemáticos como forma de estimular a criança ao aprendizado da matemática. Para tanto, aplicamos o método de pesquisa bibliográfica, que no embasa de ferramentas complementares ao estudo aqui apresentado.
A magia do circo no desenvolvimento de crianças da educação infantil
Authors: Menezes Andressa , Jung Hildegard Susana , Silva Louise de Quadros da
Published: July 2024

Esta pesquisa tem como tema a ludicidade e o circo na educação Infantil. O objetivo consiste em narrar a experiência do estágio supervisionado do Curso de Pedagogia desenvolvido em uma turma de nível III da educação infantil. Para isso, a investigação de cunho qualitativo se ancora em uma pesquisa bibliográfica, além do estudo de caso por relato de experiência como abordagem metodológica. Como principais resultados da pesquisa destacamos que o tema circo: a) oferece a oportunidade de desenvolver a expressão e as linguagens; b) potencializa o trabalho com as artes visuais, como prevê a Base Nacional Comum Curricular (BNCC); c) promove a aprendizagem de forma natural. Concluímos que a aprendizagem proposta pelo tema circo extrapola a dimensão da expressão corporal, permitindo, por meios lúdicos, além do conhecimento e percepção do próprio corpo e do espaço do corpo do outro, a diversão, o lazer e a socialização
Concepções que norteiam os documentos oficiais para a educação infantil
Authors: Silva Natiely Almeida da
Published: July 2024

Durante muito tempo o atendimento à criança foi pautado na concepção assistencialista e compensatória. Com a promulgação da Lei de Diretrizes e Bases da Educação Nacional (Lei 9394/96), a Educação Infantil passa a integrar a primeira etapa da Educação Infantil, com isso surge à concepção global que visa o desenvolvimento integral da criança, considerando a aquisição do conhecimento como uma construção coletiva e oferecendo as crianças experiências significativas. Esse presente artigo tem o objetivo de analisar as concepções da Educação Infantil (assistencialista, compensatória e a global) presentes em documentos oficiais para a Educação Infantil como: Lei de Diretrizes e Bases da Educação Nacional (LDB, 1996), Referencial Curricular Nacional para a Educação Infantil (RCNEI, 1998), Parâmetros Nacionais de Qualidade para a Educação Infantil (2006), Diretrizes Curriculares Nacionais para a Educação Infantil (DCNEI, 2010) e a Base Nacional Comum Curricular (BNCC, 2017).
GENERAL PEDAGOGICAL ISSUES OF BULLYING AT SCHOOLS AND ITS ELIMINATION WAYS
Authors: Məmmədzadə Günay
Published: July 2024

The article deals about what bullying is, its causes, and solutions that can be taken to prevent bullying. The article mentions the cases of bullying that have become a scourge of modern schools, and touches upon the approaches of a number of scientists of the world who have conducted research on this issue. Here, paying attention to the negative effects of bullying on students' lives, it is emphasized what kind of consequences the widespread cases of bullying in Azerbaijani schools have and how these cases can be prevented. In the research work, is talked about the duties of the school management in preventing bullying in secondary schools.
Penerapan Prinsip Pengembangan Materi PAI dalam Menciptakan Pembelajaran Efektif
Authors: Mokoagow Geischa , Pontoh Rini Virgiani , Mokoagow Geischa Cicilia , Solong Najamuddin Petta
Published: July 2024

Penelitian tentang penerapan prinsip pengembangan materi PAI dalam menciptakan pembelajaran efektif ini bertujuan untuk menjelaskan tentang prinsip-prinsip pembelajaran Pendidikan Agama Islam yang bersumber dari Al-Qur’an dan Hadits. Pembelajaran dalam Islam selalu memperhatikan perbedaan individu (alfarq al-fardiyyah). Bagi pendidik proses pembelajaran merupakan kewajiban yang bernilai ibadah, yang akan dipertanggungjawabkan dihadapan Allah SWT di akhirat, sehingga dalam pelaksanaannya haruslah dengan sungguh-sungguh dalam mendidik anak-anak. Hasil penelitian ini menunjukan bahwa prinsip pembelajaran berpusat pada siswa (student centered learning) merupakan pembelajaran yang lebih berpusat pada kebutuhan, minat, bakat dan kemampuan siswa, sehingga pembelajaran akan menjadi sangat bermakna. Dengan pendekatan pembelajaran berpusat pada siswa menghasilkan siswa yang berkepribadian, pintar, cerdas, aktif, mandiri, tidak bergantung pada pengajar, melainkan mampu bersaing atau berkompetisi dan memiliki kemampuan komunikasi yang lebih baik. Mengingat pentingnya peran guru, khususnya guru PAI dituntut untuk mengembangkan kompetensi mengajar secara komprehensif sehingga dapat berperan dan melaksanakan tugas mengajar atau proses belajar-mengajar PAI dengan efektif.
TRANSFORMING THE WAY TRAVELERS EXPLORE: A PHP-DRIVEN TOURS AND TRAVELS PLATFORM
Authors: Patel Aniket
Published: July 2024

Abstract: A Old Age Care Funds is a sort of investment vehicle in which the combined capital of several participants is used to purchase a diverse range of bonds, equities, and other securities. Funds, which are professionally managed, give people the chance to invest in a variety of assets without having to handle them themselves. The value of the Fund shares that investors purchase varies according to how well the underlying assets perform. Funds are well-liked by both rookie and seasoned investors because they offer diversity, liquidity, and expert management. Diverse mutual fund categories, such as stock, bond, money market, and hybrid funds, are available to suit varying investment goals and risk tolerances. Investors can select funds according to their risk tolerance, time horizon, and financial objectives. Securities regulators supervise mutual funds to maintain transparency and safeguard the interests of investors. They are now an essential instrument for people to develop a diversified investment portfolio and engage in the financial markets. Old Age Care Fund portfolio analysis is an important component of investment management that includes a variety of approaches for evaluating the performance, risk, and composition of investment portfolios. The efficient market hypothesis (EMH) states that markets are efficient and reflect all available information, making it difficult for fund managers to regularly outperform the market, according to Malkiel and Fame (1970). Jensen (1968) proposed the Capital Asset Pricing Model (CAPM), which emphasizes risk-adjusted returns and the identification of alpha, which indicates a fund manager’s capacity to create excess returns above the market. IndexTerms – Python, Powet-BI, Data Analysis.
NestMate: Simplifying Relocation with a Student-Friendly Rental System
Authors: Neware Shradha
Published: July 2024

Abstract – Relocating to a new city can be a challenging task, particularly when it comes to finding suitable accommodation. NestMate: Simplifying Relocation with a Student-Friendly Rental System is a web-based platform designed to assist employees and students during this transition by providing an intuitive interface for locating housing that fits their needs. Homeowners can register their properties on the platform and specify facilities, rules, and regulations, making it easier for users to find accommodation that matches their preferences. One of the main features of NestMate: Simplifying Relocation with a Student-Friendly Rental System is its ability to streamline the housing search process, thus reducing the stress and uncertainty of relocating to unfamiliar environments. By offering a centralized platform for property listings, NestMate: Simplifying Relocation with a Student-Friendly Rental System simplifies the housing search process and enhances the overall user experience. Additionally, NestMate: Simplifying Relocation with a Student-Friendly Rental System provides a variety of tools and resources to help users make well-informed decisions about their accommodation. This includes comprehensive property listings, photos, and virtual tours, as well as information about local amenities and neighborhood characteristics. Furthermore, the platform enables users to communicate directly with homeowners, facilitating the booking process and ensuring a seamless transition to their new location. KEYWORDS Node.js, Tailwind CSS, JavaScript, Rental Accommodation, Mess Facilities, Web-Based Platform.
Heart Failure Prediction Heart Failure Prediction Using Machine Learning
Authors: Watekar Anushka
Published: July 2024

Abstract : Cardiovascular diseases (CVDs) are the leading cause of death globally. Early detection of heart failure, a common CVD complication, is crucial for improved patient outcomes. This paper presents the development and evaluation of a machine learning model for heart failure prediction using Python Django and an XMPP database. The model utilizes various classification algorithms, including MLP Classifier, XGBoost Classifier, Random Forest Classifier, LightGBM Classifier, and K-Nearest Neighbors Classifier. We employed Sequential Feature Selection (SFS) to identify the most relevant features from the dataset, improving model accuracy and reducing user input requirements. Furthermore, Randomized Search CV was used to optimize the hyperparameters of the best-performing model (MLP Classifier), achieving a cross-validation score of 0.8899. The Django framework facilitates a user-friendly interface for data input and prediction visualization. The XMPP database provides a scalable solution for data storage and potential real-time updates. This research demonstrates the effectiveness of machine learning in predicting heart failure and highlights the potential benefits of such a system for early detection and improved cardiovascular health management.. IndexTerms – Heart Failure Prediction, Machine Learning, Cardiovascular Disease (CVD), Early Detection.
Student Engagement and Satisfaction with a College Departments Internship Portal
Authors: Navghare Rutuja .D.
Published: July 2024

Abstract: The internship program provides an excellent opportunity for budding scholars to familiarize themselves with the process of formulation of foreign policy and its implementation by the Government. Interns shall report to and work under close supervision of the concerned Head of Division (HOD). They may be required to conduct research, write reports, analyze evolving developments, or carry out any other task entrusted to them by the HOD. An honorarium of INR 10,000 per month will be paid to each intern to defray basic costs. Cost of one-time to and fro air travel subject to a ceiling of the prevailing economy class air fare between the State capital and Delhi, from the domicile State or from the college / university of the selected candidates will be provided. The interns would be responsible for their board and lodging in Delhi during the period of their internship.Every student is individually responsible for finding an internship. This implies actively seeking such a placement and directly contacting the organizations that you are interested in. We advise students to start searching for internship early on, as there may be early deadlines for some of the most attractive places. Internship ads are found in the university portal. It is allowed to receive payment from the internship organization. When contacting organization. you have the option of using our introductory letter presenting the master’s program . Please download and complete with your details before sending it to the student officefor signature. The letter of introduction may be used as a complement to the CV and personal letter that you send to potential internship organizations. KEYWORDS: HTML, CSS, Javascript, Bootsrap, C# , SQL SERVERIntroduction
Empowering Educators Engaging Students: The Impact of School Management Systems
Authors: Kubade Om
Published: July 2024

Abstract: This research paper examines the Susanskar School website project, which uses digital technology to improve educational experiences and foster community engagement. The project demonstrates the transformative potential of digital connectivity in reshaping traditional educational frameworks and creating inclusive learning environments. The study uses a comprehensive case study approach, including interviews, surveys, and website analytics, to analyze the design principles, implementation strategies, and stakeholder perceptions of the website. The findings highlight the significant impact of the project on educational engagement and community connectivity. The website’s user-friendly interface, interactive features, and rich multimedia content have facilitated communication and information dissemination among students, parents, teachers, and administrators. It has also served as a platform for showcasing student achievements, sharing educational resources, and promoting community involvement in school activities. IndexTerms – HTML, CSS, Javascript, Mysql, php.
La filosofía social de Karol Wojtyla II. Nosotros. Comunidad, sociedad y communio personarum. El bien común
Authors: Burgos Juan Manuel
Published: July 2024

Karol Wojtyla elaboró una filosofía social que se encuentra dispersa en diferentes textos entre los que destacan el capítulo “Participación” de Persona y acción, y el escrito: Persona: sujeto y comunidad. No ofreció, sin embargo, en ningún momento una visión sistemática de su pensamiento por lo que resulta complejo finar sus posiciones sobre estos temas. El objetivo de este escrito es solventar esa carencia presentando de manera sistemática su filosofía social y posibilitando también de este modo su valoración. Nuestro análisis ha detectado 8 puntos centrales a través de los cuales expondremos su pensamiento: 1) Primacía de la persona; 2) Valor personalista de la acción: participación y alienación; 3) Yo-tú: la dimensión interpersonal de la comunidad; 4) El nosotros: la dimensión social de la comunidad; 5) Comunidad, sociedad y Communio personarum; 6) La persona en la sociedad: individualismo, colectivismo y personalismo; 7) El bien común: la construcción conjunta de la persona y la comunidad; 8) Actitudes ante el bien común. Por la extensión de este trabajo, el escrito se divide en dos artículos. En el primero, se presentan los puntos 1 a 3, y en el segundo, los 5 restantes. El conjunto de la investigación muestra de manera clara la originalidad y potencia de esta reflexión, a pesar de cierta falta de sistematicidad.
Swyer Syndrome with Gonadoblastoma: A Case Report
Authors: TB Ahmend , ME Ha que , N Huq
Published: July 2024

These patients have female external phenotype and usually presented with primary amenorrhea.Detailed history, clinical, radiological and hormonal evaluation, karyotyping and histopathologyare needed for diagnosis. Due to the presence of Y chromosomes these patients have streak gonadswith increased risk of development of gonadoblastoma. Early diagnosis of Swyer syndromefollowed by prophylactic gonadectomy is very important. Case presentation: A 19-year-old female presented with the complaints of primary amenorrhea.The clinical, radiological, hormonal assessment and karyotyping test made the diagnosis of Swyersyndrome. The histopathological examination revealed left sided streak gonad and right sidedgonadoblastoma.Conclusion: Swyer syndrome is a rare form of disorders of sexual development. As there is highchance of gonadal malignancy, these patients should be counseled for preventive bilateral salpingooophorectomy
Global care chains and empowerment through the social economy: women’s participation in care cooperatives
Authors: García-Azpuru Amaia , Izagirre-Olaizola Julen , Etxezarreta-Etxarri Aitziber , Díaz Molina Liseth
Published: July 2024

The main objective of this paper is to analyse women’s participation in care cooperatives as a fundamental tool for their empowerment. To this end, concepts related to migration, participation in the social economy and women’s empowerment are discussed. The situation of crisis of the traditional care system in the Global North attracts foreign female migration to partially alleviate the problem. However, these women face conditions of vulnerability and precariousness. Global care chains emerge, entailing high family and personal costs for the weakest link.In this context, this study develops a qualitative analysis based on in-depth interviews with workers from three care cooperatives in the Basque Country. The aim is to highlight, through an exploratory thematic analysis, the way in which the social economy, through care cooperatives, can be a fundamental tool for the empowerment of women (migrant or not) involved in the care sector.The analysis of the information reveals that the cooperative is an ideal way to encourage women’s participation and this, in turn, leads to increased confidence, self-esteem and, in general, a sense of empowerment for these women. However, additional difficulties and barriers are also identified for women migrants in an irregular situation.
Análisis de la transformación digital en las cooperativas agroalimentarias desde la perspectiva de género
Authors: Guzmán Carmen , Santos Francisco J. , Ahumada Pedro
Published: July 2024

La transformación digital (TD) implica la aparición de nuevos modelos de negocio basados en el uso generalizado de las tecnologías digitales. La TD es necesaria para mejorar la productividad y el acceso a los mercados; sin embargo, desde la perspectiva de género, existe una brecha digital. En esta investigación, el objetivo es estudiar la TD desde la perspectiva de género en un sector específico, el agroalimentario, y en un tipo de entidad específico de la economía social que es fundamental en las zonas rurales, las cooperativas agroalimentarias. En estas empresas sigue habiendo una brecha de género, especialmente debido a la menor proporción de mujeres en los equipos directivos y, además, presentan un atraso en su TD respecto a otras empresas. En concreto, se analiza la TD en estas cooperativas tanto globalmente como mediante el análisis de cada una de sus dimensiones: infraestructuras, productos, organización, procesos y clientes. Para ello se utilizan los datos de una encuesta a una muestra de cooperativas agroalimentarias extremeñas, región con una fuerte especialización en el sector agroalimentario y donde las cooperativas desempeñan una importante función económica, social y medioambiental. Los resultados muestran que la presencia de mujeres en la presidencia de estas cooperativas influye positivamente en la presencia de mujeres en sus equipos directivos. Asimismo, no existen diferencias significativas en la TD global de estas cooperativas respecto al factor género, aunque sí en las dimensiones específicas de “clientes” y “procesos”.
La diversidad de género como instrumento de buen gobierno en las cooperativas
Authors: García Companys Anna
Published: July 2024

El artículo propone una revisión de las leyes de cooperativas españolas con el objeto de identificar aquellas disposiciones que contienen medidas para favorecer la igualdad de género en la composición de los órganos de administración y dirección de estas sociedades. Teniendo en cuenta que la igualdad es uno de los valores esenciales de la identidad cooperativa, sería esperable que la concreción de este principio en el contexto del gobierno corporativo estuviera, cuando menos, al nivel del previsto para las sociedades capitalistas, especialmente las sociedades cotizadas con quienes las sociedades cooperativas comparten similar estructura corporativa. Sin embargo, el análisis evidencia que, si bien algunas leyes autonómicas destacan por haber incluido medidas significativas en esta materia de carácter genérico, societario, económico y de fomento, la mayoría sigue sin explicitar ningún compromiso con la igualdad de género. Por ello, se considera conveniente formular una serie de principios y recomendaciones sobre esta materia en la línea de los previstos en el Código de Buen Gobierno de Sociedades Cotizadas (CBGSC) a las que todo el movimiento debería adherirse sometiéndose al principio comply or explain. En este sentido, los Principios del Derecho Cooperativo Europeo (PECOL) podrían servir como inspiración.
Revealing unexpected complex encoding but simple decoding mechanisms in motor cortex via separating behaviorally relevant neural signals
Authors: Li Yangang , Zhu Xinyun , Qi Yu , Wang Yueming
Published: July 2024

In motor cortex, behaviorally-relevant neural responses are entangled with irrelevant signals, which complicates the study of encoding and decoding mechanisms. It remains unclear whether behaviorally-irrelevant signals could conceal some critical truth. One solution is to accurately separate behaviorally-relevant and irrelevant signals at both single-neuron and single-trial levels, but this approach remains elusive due to the unknown ground truth of behaviorally-relevant signals. Therefore, we propose a framework to define, extract, and validate behaviorally-relevant signals. Analyzing separated signals in three monkeys performing different reaching tasks, we found neural responses previously considered to contain little information actually encode rich behavioral information in complex nonlinear ways. These responses are critical for neuronal redundancy and reveal movement behaviors occupy a higher-dimensional neural space than previously expected. Surprisingly, when incorporating often-ignored neural dimensions, behaviorally-relevant signals can be decoded linearly with comparable performance to nonlinear decoding, suggesting linear readout may be performed in motor cortex. Our findings prompt that separating behaviorally-relevant signals may help uncover more hidden cortical mechanisms.
A synergistic workspace for human consciousness revealed by Integrated Information Decomposition
Authors: Luppi Andrea I , Mediano Pedro AM , Rosas Fernando E , Allanson Judith , Pickard John , Carhart-Harris Robin L , Williams Guy B , Craig Michael M , Finoia Paola , Owen Adrian M , Naci Lorina , Menon David K , Bor Daniel , Stamatakis Emmanuel A
Published: July 2024

How is the information-processing architecture of the human brain organised, and how does its organisation support consciousness? Here, we combine network science and a rigorous information-theoretic notion of synergy to delineate a ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across the human brain. This information is then integrated within the workspace and widely distributed via broadcaster regions. Through functional MRI analysis, we show that gateway regions of the synergistic workspace correspond to the human brain’s default mode network, whereas broadcasters coincide with the executive control network. We find that loss of consciousness due to general anaesthesia or disorders of consciousness corresponds to diminished ability of the synergistic workspace to integrate information, which is restored upon recovery. Thus, loss of consciousness coincides with a breakdown of information integration within the synergistic workspace of the human brain. This work contributes to conceptual and empirical reconciliation between two prominent scientific theories of consciousness, the Global Neuronal Workspace and Integrated Information Theory, while also advancing our understanding of how the human brain supports consciousness through the synergistic integration of information.
Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons
Authors: Hiramatsu Shun , Saito Kokoro , Kondo Shu , Katow Hidetaka , Yamagata Nobuhiro , Wu Chun-Fang , Tanimoto Hiromu
Published: July 2024

Dopamine can play opposing physiological roles depending on the receptor subtype. In the fruit fly Drosophila melanogaster, Dop1R1 and Dop2R encode the D1- and D2-like receptors, respectively, and are reported to oppositely regulate intracellular cAMP levels. Here, we profiled the expression and subcellular localization of endogenous Dop1R1 and Dop2R in specific cell types in the mushroom body circuit. For cell-type-specific visualization of endogenous proteins, we employed reconstitution of split-GFP tagged to the receptor proteins. We detected dopamine receptors at both presynaptic and postsynaptic sites in multiple cell types. Quantitative analysis revealed enrichment of both receptors at the presynaptic sites, with Dop2R showing a greater degree of localization than Dop1R1. The presynaptic localization of Dop1R1 and Dop2R in dopamine neurons suggests dual feedback regulation as autoreceptors. Furthermore, we discovered a starvation-dependent, bidirectional modulation of the presynaptic receptor expression in the protocerebral anterior medial (PAM) and posterior lateral 1 (PPL1) clusters, two distinct subsets of dopamine neurons, suggesting their roles in regulating appetitive behaviors. Our results highlight the significance of the co-expression of the two opposing dopamine receptors in the spatial and conditional regulation of dopamine responses in neurons.
Cell-type-specific fluorescent tagging of endogenous target proteins reveals synaptic enrichment and dynamic regulations of dopamine receptors
Authors: Hiramatsu Shun , Saito Kokoro , Kondo Shu , Katow Hidetaka , Yamagata Nobuhiro , Wu Chun-Fang , Tanimoto Hiromu
Published: July 2024

Dopamine can play opposing physiological roles depending on the receptor subtype. In the fruit fly
Drosophila melanogaster
,
Dop1R1
and
Dop2R
encode the D
1
- and D
2
-like receptors, respectively, and are reported to oppositely regulate intracellular cAMP levels. Here, we profiled the expression and subcellular localization of endogenous Dop1R1 and Dop2R in specific cell types in the mushroom body circuit. For cell-type-specific visualization of endogenous proteins, we employed reconstitution of split-GFP tagged to the receptor proteins. We detected dopamine receptors at both presynaptic and postsynaptic sites in multiple cell types. Quantitative analysis revealed enrichment around the active zones, particularly for Dop2R. The presynaptic localization of Dop1R1 and Dop2R in dopamine neurons suggests dual feedback regulation as autoreceptors. Furthermore, we discovered a starvation-dependent, bidirectional modulation of the presynaptic receptor expression in the PAM and PPL1 clusters, two distinct subsets of dopamine neurons, suggesting regulation of appetitive behaviors. Our results highlight the significance of the co-expression of the two antagonizing dopamine receptors in the spatial and conditional regulation of dopamine responses in neurons.
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
Authors: Shang Jinsai , Kojetin Douglas J
Published: July 2024

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor transcription factor that regulates gene expression programs in response to ligand binding. Endogenous and synthetic ligands, including covalent antagonist inhibitors GW9662 and T0070907, are thought to compete for the orthosteric pocket in the ligand-binding domain (LBD). However, we previously showed that synthetic PPARγ ligands can cooperatively cobind with and reposition a bound endogenous orthosteric ligand to an alternate site, synergistically regulating PPARγ structure and function (Shang et al., 2018). Here, we reveal the structural mechanism of cobinding between a synthetic covalent antagonist inhibitor with other synthetic ligands. Biochemical and NMR data show that covalent inhibitors weaken—but do not prevent—the binding of other ligands via an allosteric mechanism, rather than direct ligand clashing, by shifting the LBD ensemble toward a transcriptionally repressive conformation, which structurally clashes with orthosteric ligand binding. Crystal structures reveal different cobinding mechanisms including alternate site binding to unexpectedly adopting an orthosteric binding mode by altering the covalent inhibitor binding pose. Our findings highlight the significant flexibility of the PPARγ orthosteric pocket, its ability to accommodate multiple ligands, and demonstrate that GW9662 and T0070907 should not be used as chemical tools to inhibit ligand binding to PPARγ.
The optimization and operation of multi-energy-coupled microgrids by the improved fireworks algorithm-shuffled frog-leaping algorithm
Authors: Yue Xubo , Zhang Jing , Guo Junhui , Li Jianfei , Chen Diyu
Published: July 2024

This study aims to address optimization and operational challenges in multi-energy coupled microgrids to enhance system stability and reliability. After analyzing the requirements of such systems within comprehensive energy systems, an improved fireworks algorithm (IFWA) is proposed. This algorithm combines an adaptive resource allocation strategy with a community genetic strategy, automatically adjusting explosion range and spark quantity based on individual optimization status to meet actual needs. Additionally, a multi-objective optimization model considering active power network losses and static voltage is constructed, utilizing the shuffled frog-leaping algorithm (SFLA) to solve constrained multi-objective optimization problems. Through simulation experiments on a typical northern comprehensive energy system, conducted with a scheduling period of T = 24, the feasibility and superiority of IFWA-SFLA are validated. Results indicate that IFWA-SFLA performs well in optimizing microgrid stability, managing electrical energy flow effectively within the microgrid, and reducing voltage fluctuations. Furthermore, the circuit structure and control strategy of microgrid energy storage bidirectional inverters based on IFWA are discussed, along with relevant simulation results.
Classification of major species in the sericite–Artemisia desert grassland using hyperspectral images and spectral feature identification
Authors: Liu Wenhao , Han Wanqiang , Jin Guili , Gong Ke , Ma Jian
Published: July 2024

Background

The species composition of and changes in grassland communities are important indices for inferring the number, quality and community succession of grasslands, and accurate monitoring is the foundation for evaluating, protecting, and utilizing grassland resources. Remote sensing technology provides a reliable and powerful approach for measuring regional terrain information, and the identification of grassland species by remote sensing will improve the quality and effectiveness of grassland monitoring.

Methods

Ground hyperspectral images of a sericite–Artemisia desert grassland in different seasons were obtained with a Soc710 VP imaging spectrometer. First-order differential processing was used to calculate the characteristic parameters. Analysis of variance was used to extract the main species, namely, Seriphidium transiliense (Poljak), Ceratocarpus arenarius L., Petrosimonia sibirica (Pall), bare land and the spectral characteristic parameters and vegetation indices in different seasons. On this basis, Fisher discriminant analysis was used to divide the samples into a training set and a test set at a ratio of 7:3. The spectral characteristic parameters and vegetation indices were used to identify the three main plants and bare land.

Results

The selection of parameters with significant differences (P < 0.05) between the recognition objects effectively distinguished different land features, and the identification parameters also differed due to differences in growth period and species. The overall accuracy of the recognition model established by the vegetation index decreased in the following order: June (98.87%) > September (91.53%) > April (90.37%). The overall accuracy of the recognition model established by the feature parameters decreased in the following order: September (89.77%) > June (88.48%) > April (85.98%).

Conclusions

The recognition models based on vegetation indices in different months are superior to those based on feature parameters, with overall accuracies ranging from 1.76% to 9.40% higher. Based on hyperspectral image data, the use of vegetation indices as identification parameters can enable the identification of the main plants in sericite–Artemisia desert grassland, providing a basis for further quantitative classification of the species in community images.
Monitoring deforestation, forest health, and environmental criticality in a protected area periphery using Geospatial Techniques
Authors: Withanage Neel Chaminda , Mishra Prabuddh Kumar , Abdelrahman Kamal , Singh Rajender
Published: July 2024

Protected areas in South Asia face significant challenges due to human disturbance and deforestation. The ongoing debate surrounds the recent surge in illegal encroachment of forest buffer zones in the Musali divisional secretariat division (DSD), which has led to a significant loss of forest cover over the past three decades. In this context, detecting changes in forest cover, assessing forest health, and evaluating environmental quality are crucial for sustainable forest management. As such, our efforts focused on assessing forest cover dynamics, forest health, and environmental conditions in the DSD from 1988 to 2022. We employed standardized image processing techniques, utilizing Landsat-5 (TM) and Landsat-8 (OLI) images. However, the forest area in the DSD has shown minimal changes, and environmental conditions and forest health have illustrated considerable spatial-temporal variations over the 34 years. The results indicated that 8.5 km2 (1.9%) of forest cover in the DSD has been converted to other land use classes. Overall, the Normalized Difference Vegetation Index (NDVI) has declined over time, while Land Surface Temperature (LST) exhibits an increasing trend. The regression results demonstrated a robust inverse relationship between LST and NDVI. The declining vegetation conditions and the increasing LST contribute to an increase in environmental criticality. The derived maps and indices will be beneficial for forest authorities in identifying highly sensitive locations. Additionally, they could enable land use planners to develop sustainable land management strategies.
Impacts of Aircraft Noise on Psychosocial Health of Man: A Study in Sam Mbakwe International Cargo Airport, Imo State, Nigeria
Authors: Acholonu Chidinma , Bridget Diagi E. , Nwaogu Chukwudi , Okorondu Justin N. , Chinonye Ekweogu , Susan Ajiere , Victor Agidi , Uyo Chijioke , Ifeoma Obijuru
Published: July 2024

Noise can be seen as unwanted sound which is unpleasant to man and the Environment. One of the sources of noise pollution which has effect on man is aircraft noise.  Noise assessment level data were obtained at three stages of aircraft operation; Standby, Take-off and Landing for a period of five days. Two airlines within the same age limit were assessed for the study. The sound meter utilized in this study is sound meter android application. It has the measurement range of 30 to 130 dB(A) with an accuracy of ±2 dB(A) and resolution 0.1 dB(A). 100 copies of structured questionnaire were used to solicit information within the airport environment from workers on the perceived effects of aircraft noise on their health and daily activities within the airport. Data were collected and compared with World Health Organization (W.H.O) standard. Findings of the study revealed that the recorded noise levels were above the W.H.O permissible limit. Although, there were variation in noise level between the two airlines and the different stages assessed.  Findings from the questionnaire survey also revealed that 80% of the population admitted that the noise levels had impact on their health ranging from annoyance, stress, deprivation of sleep, hearing problems amongst others.  The study confirmed that aircraft noise had an impact on health and well-being of people. The study therefore, recommends that there is need to reduce the aviation noise impacts in other to promote human and environmental health.