bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of patient–family physician language concordance on healthcare utilisation and mortality: a retrospective cohort study of home care recipients in Ontario, Canada
Authors: Reaume Michael , Batista Ricardo , Sucha Ewa , Pugliese Michael , Roberts Rhiannon , Rhodes Emily , Seale Emily , Kendall Claire , Bjerre Lise , Bouchard Louise , Johnston Sharon , Sood Manish , Prud'homme Denis , Manuel Douglas , Tanuseputro Peter
Published: June 2024

Introduction

As the world’s linguistic diversity continues to increase at an unprecedented rate, a growing proportion of patients will be at risk of experiencing language barriers in primary care settings. We sought to examine whether patient–family physician language concordance in a primary care setting is associated with lower rates of hospital-based healthcare utilisation and mortality.

Methods

We conducted a population-based retrospective cohort study of 497 227 home care recipients living in Ontario, Canada. Patient language was obtained from home care assessments while physician language was obtained from the College of Physicians and Surgeons of Ontario. We defined primary care as language concordant when patients and their rostered family physicians shared a mutually intelligible language, and we defined all other primary care as language discordant. The primary outcomes were Emergency Department (ED) visits, hospitalisations and death within 1 year of index home care assessment.

Results

Compared with non-English, non-French speakers who received language-discordant primary care, those who received language-concordant primary care experienced fewer ED visits (53.1% vs 57.5%; p<0.01), fewer hospitalisations (35.0% vs 37.6%; p<0.01) and less mortality (14.4% vs 16.6%; p<0.01) during the study period. In multivariable regression analyses, non-English, non-French speakers had lower risks of ED visits (adjusted hazard ratio [aHR] 0.91, 95% CI 0.88 to 0.94), hospitalisations (aHR 0.94, 95% CI 0.90 to 0.98) and death (aHR 0.87, 95% CI 0.82 to 0.93) when they received language-concordant primary care. For francophones, the risk of experiencing an ED visit, a hospitalisation or death was not impacted by the language of their family physician.

Conclusions

Patient–family physician language concordance is associated with a lower risk of adverse outcomes in non-English and non-French speakers. Optimising the delivery of language-concordant care could potentially result in significant decreases in the use of acute healthcare services and mortality at the population level.
Persistent effects of legal status on healthcare access and outcomes: findings from a state-wide representative cross-sectional survey in California
Authors: Sudhinaraset May , Chen Lei , Pourat Nadereh , Nakphong Michelle Kao , De Trinidad Young Maria-Elena
Published: June 2024

Background

To examine how legal status and past undocumented status are associated with healthcare access and health outcomes.

Methods

Data were collected between 2018 and 2020 as a follow-on, cross-sectional survey to the California Health Interview Survey (N=2010). We used multiple regression models to assess associations between past and current legal status and usual source of care, delayed medical care and psychological distress.

Results

Overall, 26.2% of the sample had ever been undocumented. Compared with citizens who have always held lawful status (CLS), non-citizens who were previously undocumented (adjusted OR (aOR)=0.48, p<0.05) and non-citizens who have always held lawful status (NLS) (aOR=0.41, p<0.01) were less likely to have a usual source of care. Citizens who were previously undocumented were more likely to delay medical care (aOR=2.32, p<0.05) compared with CLS. NLS were more likely to have moderate and above distress (aOR=2.31, p<0.01) compared with CLS.

Conclusion

Public health efforts are needed to address the burden of trauma and disadvantage among those experiencing persistent effects of undocumented status.
Development and use of axial load test databases for analysis and design of soft rock sockets
Authors: Ye Xiaoyong , Tang Chong , Phoon Kok-Kwang , Chen Jinbo
Published: June 2024

This paper presents the state of knowledge of analysis and design of rock sockets—main features of axial loading behavior and influential factors, methods for predicting the mobilized strength (shaft shearing fs and end bearing qb) and load–displacement ( Q– w) curves. A total number of 363 field load tests on full-scale rock sockets are compiled into a database—DUT/PileROC/363 and analyzed in a consistent manner. This database is used to evaluate the variability of predictions of mobilized resistances ( fs and qb), loads Qa at settlements w = 5–20 mm and 0.5%–2% of socket diameter, and Q– w curves. For fs, qb, and Qa, the results are characterized as the mean and coefficient of variation (COV) of the ratio of measured over predicted values. It is observed that (1) both shaft shearing and end bearing can be mobilized at small displacements when good construction and inspection procedures are followed, (2) the majority of empirical models for fs and qb are too simplistic (solely accounting for the unconfined compressive strength of rock) and the resulting predictions are highly dispersive (COV > 0.6), (3) the prediction quality does not necessarily improve with an increased level of model sophistication, (4) rock mass modulus Em is crucial for predicting Qa and Q– w curves, (5) predictions of Qa by one nonlinear and two side-slip design methods are of medium dispersion (COV = 0.3–0.6), and (6) only the nonlinear design method produces Q– w curves that resemble the shape of measured Q– w curves in load tests.
Geochronology of the Mines Gaspé porphyry deposit, Québec, Canada
Authors: Marcelissen Mitch , Hollings Pete , Cooke David R. , Baker Michael J. , Belousov Ivan , Orovan Evan , Friedman Richard
Published: June 2024

The Mines Gaspé area hosts multiple Cu–Mo skarn and porphyry orebodies near the town of Murdochville in the northeastern part of the Gaspé Peninsula, Québec. The orebodies occur within overlapping alteration aureoles in calcareous Lower Devonian sedimentary rocks. The strata are intruded by numerous multiphase porphyry sills, dykes, and plugs of Devonian age. The Porphyry Mountain intrusion and a sill in the Copper Mountain pit have been dated at 378.80 ± 0.37 and 377.60 ± 0.45 Ma, respectively, refining the results of previous studies, and demonstrating Porphyry Mountain intrusion emplacement at least 0.38 m.y. before Copper Mountain. Circa 392 Ma inherited zircon grains at Mines Gaspé suggest an early phase of magmatism that produced the extensive skarn alteration aureoles throughout the Gaspé Peninsula at sites such as Mines Gaspé and the nearby McGerrigle Complex, followed by significantly later (>10 m.y.) porphyritic intrusions and associated mineralization that added to existing skarn resources. Epidote at both Mines Gaspé and Sullipek occur as disseminated/granular crystals within the host groundmass and as larger crystals within veinlets or veinlet halos in metasomatised sedimentary rocks. Epidote ages suggest that there are several different propylitic hydrothermal events within the region at Mines Gaspé and Sullipek, which combined with new zircon U–Pb ages implies a prolonged and complex history of propylitic alteration within Gaspésie.
Working towards decolonial futures in Canada: first steps for non-Indigenous fisheries researchers
Authors: Cadman Rachael , Bodwitch Hekia , Hamelin Kayla M. , Ortenzi Kate , Seidler Dylan , Sinan Hussain , Kim Abigael , Akinrinola Grace , Sheik Heile Abdirahim , Hopton Aimée , Bailey Megan
Published: June 2024

Motivated by the leadership, scholarship, and activism of Indigenous Peoples, there are growing calls to transform and decolonize Canadian institutions that govern fisheries research in Canada. As a predominantly non-Indigenous group that works at the intersection of fisheries and justice, we encounter questions daily about how to act as allies in these efforts and take up this urgent call in our own work. Our goal with this perspective is to synthesize and share some of what we have learned about encountering and combatting colonialism in the hope that it may offer something to other non-Indigenous and settler fisheries researchers who are grappling with colonization in their own work. This synthesis is based on both Indigenous scholarship and our own experiential learning. We look to actions fisheries researchers may take to advance Indigenous sovereignty in fisheries research. We offer this to our fellow non-Indigenous researchers who likely also struggle with similar questions, and hope that in doing so, we can help move towards decolonial fisheries futures.
Laplace’s first law of errors applied to diffusive motion
Authors: Hamdi Omer , Burov Stanislav , Barkai Eli
Published: June 2024

In biological, glassy, and active systems, various tracers exhibit Laplace-like, i.e., exponential, spreading of the diffusing packet of particles. The limitations of the central limit theorem in fully capturing the behaviors of such diffusive processes, especially in the tails, have been studied using the continuous time random walk model. For cases when the jump length distribution is super-exponential, e.g., a Gaussian, we use large deviations theory and relate it to the appearance of exponential tails. When the jump length distribution is sub-exponential, the packet of spreading particles is described by the big jump principle. We demonstrate the applicability of our approach for finite time, indicating that rare events and the asymptotics of the large deviations rate function can be sampled for large length scales within a reasonably short measurement time.

Graphical abstract

The universality of Laplace tails appears everywhere
Automatic Algerian Sarcasm Detection from Texts and Images
Authors: Bousmaha Kheira Zineb , Hamadouche Khaoula , Djouabi Hadjer , Hadrich-Belguith Lamia
Published: June 2024

In recent years, the number of Algerian Internet users has significantly increased, providing a valuable opportunity for collecting and utilizing opinions and sentiments expressed online. They now post not just texts but also images. However, to benefit from this wealth of information, it is crucial to address the challenge of sarcasm detection, which poses a limitation in sentiment analysis. Sarcasm often involves the use of nonliteral and ambiguous language, making its detection complex. To enhance the quality and relevance of sentiment analysis, it is essential to develop effective methods for sarcasm detection. By overcoming this limitation, we can fully harness the expressed online opinions and benefit from their valuable insights for a better understanding of trends and sentiments among the Algerian public. In this work, our aim is to develop a comprehensive system that addresses sarcasm detection in Algerian dialect, encompassing both text and image analysis. We propose a hybrid approach that combines linguistic characteristics and machine learning techniques for text analysis. Additionally, for image analysis, we utilized the deep learning model VGG-19 for image classification, and employed the EasyOCR technique for Arabic text extraction. By integrating these approaches, we strive to create a robust system capable of detecting sarcasm in both textual and visual content in the Algerian dialect. Our system achieved an accuracy of 92.79% for the textual models and 89.28% for the visual model.
KannadaLex: A lexical database with psycholinguistic information
Authors: Aithal Shreya R. , Sn Muralikrishna , Ganiga Raghavendra , Rao B. Ashwath , Hegde K. Govardhan
Published: June 2024

Databases containing lexical properties are of primary importance to psycholinguistic research and speech-language therapy. Several lexical databases for different languages have been developed in the recent past, but Kannada, a language spoken by 50.8 million people, has no comprehensive lexical database yet. To address this,
KannadaLex
, a Kannada lexical database, is built as a language resource that contains orthographic, phonological, and syllabic information about words that are sourced from newspaper articles from the past decade. Along with these vital statistics such as the phonological neighborhood, syllable complexity summed syllable and bigram syllable frequencies, and lemma and inflectional family information are stored. The database is validated by correlating frequency, a well-established psycholinguistic feature, with other numerical features. The developed lexical database contains 170K words from varied disciplines, complete with psycholinguistic features. This
KannadaLex
is a comprehensive resource for psycholinguists, speech therapists, and linguistic researchers for analyzing Kannada and other similar languages. Psycholinguists require lexical data for choosing stimuli to conduct experiments that study the factors that enable humans to acquire, use, comprehend, and produce language. Speech and language therapists query these databases for developing the most efficient stimuli for evaluating, diagnosing, and treating communication disorders, and rehabilitation of speech after brain injuries.
Supplemental Table 8 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors
Authors: Hathaway Cassandra A. , Townsend Mary K. , Wang Tianyi , Vinci Christine , Jake-Schoffman Danielle E. , Hecht Jonathan L. , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Conejo-Garcia Jose R. , Fridley Brooke L. , Tworoger Shelley S.
Published: June 2024

Supplemental Table 8: Hazard ratios and 95% confidence intervals between smoking and ovarian cancer risk by tumor immune infiltration of immunoglobulins, NHS and NHSII
Supplemental Table 7 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors
Authors: Hathaway Cassandra A. , Townsend Mary K. , Wang Tianyi , Vinci Christine , Jake-Schoffman Danielle E. , Hecht Jonathan L. , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Conejo-Garcia Jose R. , Fridley Brooke L. , Tworoger Shelley S.
Published: June 2024

Supplemental Table 7: Hazard ratios and 95% confidence intervals between smoking and ovarian cancer risk by tumor immune infiltration of B cells, NHS and NHSII
Supplementary Table S1 from Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)
Authors: Habeshian Talar S. , Peeri Noah C. , De Vivo Immaculata , Schouten Leo J. , Shu Xiao-ou , Cote Michele L. , Bertrand Kimberly A. , Chen Yu , Clarke Megan A. , Clendenen Tess V. , Cook Linda S. , Costas Laura , Dal Maso Luigino , Freudenheim Jo L. , Friedenreich Christine M. , Gallagher Grace , Gierach Gretchen L. , Goodman Marc T. , Jordan Susan J. , La Vecchia Carlo , Lacey James V. , Levi Fabio , Liao Linda M. , Lipworth Loren , Lu Lingeng , Matias-Guiu Xavier , Moysich Kirsten B. , Mutter George L. , Na Renhua , Naduparambil Jeffin , Negri Eva , O'Connell Kelli , O'Mara Tracy A. , Onieva Hernández Irene , Palmer Julie R. , Parazzini Fabio , Patel Alpa V. , Penney Kathryn L. , Prizment Anna E. , Ricceri Fulvio , Risch Harvey A. , Sacerdote Carlotta , Sandin Sven , Stolzenberg-Solomon Rachael Z. , van den Brandt Piet A. , Webb Penelope M. , Wentzensen Nicolas , Wijayabahu Akemi T. , Wilkens Lynne R. , Xu Wanghong , Yu Herbert , Zeleniuch-Jacquotte Anne , Zheng Wei , Du Mengmeng , Setiawan Veronica Wendy
Published: June 2024

Characteristics of the 27 studies included in the E2C2 pooled analysis
Supplemental Table 4 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors
Authors: Hathaway Cassandra A. , Townsend Mary K. , Wang Tianyi , Vinci Christine , Jake-Schoffman Danielle E. , Hecht Jonathan L. , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Conejo-Garcia Jose R. , Fridley Brooke L. , Tworoger Shelley S.
Published: June 2024

Supplemental Table 4: Percent positive immune cells or Ig positive cells in the tumor among all cells in the tumor by ovarian tumor subtype in NHS and NHSII
Supplementary Figure S1 from Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)
Authors: Habeshian Talar S. , Peeri Noah C. , De Vivo Immaculata , Schouten Leo J. , Shu Xiao-ou , Cote Michele L. , Bertrand Kimberly A. , Chen Yu , Clarke Megan A. , Clendenen Tess V. , Cook Linda S. , Costas Laura , Dal Maso Luigino , Freudenheim Jo L. , Friedenreich Christine M. , Gallagher Grace , Gierach Gretchen L. , Goodman Marc T. , Jordan Susan J. , La Vecchia Carlo , Lacey James V. , Levi Fabio , Liao Linda M. , Lipworth Loren , Lu Lingeng , Matias-Guiu Xavier , Moysich Kirsten B. , Mutter George L. , Na Renhua , Naduparambil Jeffin , Negri Eva , O'Connell Kelli , O'Mara Tracy A. , Onieva Hernández Irene , Palmer Julie R. , Parazzini Fabio , Patel Alpa V. , Penney Kathryn L. , Prizment Anna E. , Ricceri Fulvio , Risch Harvey A. , Sacerdote Carlotta , Sandin Sven , Stolzenberg-Solomon Rachael Z. , van den Brandt Piet A. , Webb Penelope M. , Wentzensen Nicolas , Wijayabahu Akemi T. , Wilkens Lynne R. , Xu Wanghong , Yu Herbert , Zeleniuch-Jacquotte Anne , Zheng Wei , Du Mengmeng , Setiawan Veronica Wendy
Published: June 2024

Figure S1 shows the study flowchart for the inclusion of participants. It depicts how we arrived at our final analytic population.
Supplemental Table 2 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors
Authors: Hathaway Cassandra A. , Townsend Mary K. , Wang Tianyi , Vinci Christine , Jake-Schoffman Danielle E. , Hecht Jonathan L. , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Conejo-Garcia Jose R. , Fridley Brooke L. , Tworoger Shelley S.
Published: June 2024

Supplemental Table 2: Age-standardized baseline characteristics by parental smoking during childhood or adolescence, NHS (1982) and NHSII (1999)
Supplemental Table 1 from Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors
Authors: Hathaway Cassandra A. , Townsend Mary K. , Wang Tianyi , Vinci Christine , Jake-Schoffman Danielle E. , Hecht Jonathan L. , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Conejo-Garcia Jose R. , Fridley Brooke L. , Tworoger Shelley S.
Published: June 2024

Supplemental Table 1: List of Markers Included in Analyses
Table 2 from Assessing the Value of Incorporating a Polygenic Risk Score with Nongenetic Factors for Predicting Breast Cancer Diagnosis in the UK Biobank
Authors: Collister Jennifer A. , Liu Xiaonan , Littlejohns Thomas J. , Cuzick Jack , Clifton Lei , Hunter David J.
Published: June 2024

Breakdown of case and control classification in the test data (N = 25,369) using 10-year risks from the Tyrer-Cuzick model with and without PRSBC, with a fixed proportion (6.47%) of women considered at “moderate risk”.
Figure 2 from Assessing the Value of Incorporating a Polygenic Risk Score with Nongenetic Factors for Predicting Breast Cancer Diagnosis in the UK Biobank
Authors: Collister Jennifer A. , Liu Xiaonan , Littlejohns Thomas J. , Cuzick Jack , Clifton Lei , Hunter David J.
Published: June 2024

Time-dependent ROC plots at 10 years of follow up for both the Tyrer–Cuzick (left) and Gail (right) models, with and without PRSBC, as well as PRSBC alone in test data (N = 25,369).
Figure 1 from Assessing the Value of Incorporating a Polygenic Risk Score with Nongenetic Factors for Predicting Breast Cancer Diagnosis in the UK Biobank
Authors: Collister Jennifer A. , Liu Xiaonan , Littlejohns Thomas J. , Cuzick Jack , Clifton Lei , Hunter David J.
Published: June 2024

Calibration plots of 10-year observed versus predicted risk by risk decile, for the Tyrer–Cuzick and Gail models, plotting the observed proportion of women with breast cancer by 10 years of follow-up against the predicted 10-year risk from the models. Top row, predicted risks in training dataset from Tyrer–Cuzick and Gail models. Middle row, predicted risks in test dataset from Tyrer–Cuzick and Gail models, calibrated using the training dataset. Bottom row, predicted risks in test dataset from Cox model containing Tyrer–Cuzick or Gail model and PRSBC, developed in training dataset.
Supplementary Figure S4 from Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy
Authors: Magbanua Mark Jesus M. , Ahmed Ziad , Sayaman Rosalyn W. , Brown Swigart Lamorna , Hirst Gillian L. , Yau Christina , Wolf Denise M. , Li Wen , Delson Amy L. , Perlmutter Jane , Pohlmann Paula , Symmans W. Fraser , Yee Douglas , Hylton Nola M. , Esserman Laura J. , DeMichele Angela M. , Rugo Hope S. , van 't Veer Laura J.
Published: June 2024

Relationship of cfDNA concentration and circulating tumor DNA (ctDNA) with residual cancer burden (RCB) index. A. CfDNA (ng/mL, log10-transformed) and B. ctDNA concentrations (mean tumor molecules per mL of plasma, MTM/ml, log10-transformed) were measured in the plasma of patients with hormone receptor-positive HER2-negative (HR+HER2-) and triple-negative breast cancer (TNBC). The RCB index is a continuous measure of residual cancer in the breast and axillary lymph nodes after neoadjuvant chemotherapy, with an RCB index of zero equivalent to a pathologic complete response. The blue line represents the regression line, and the gray shading shows the 95% confidence interval. Pearson’s correlation test was used to calculate the correlation coefficient and the p-value. Blood was collected at pretreatment (T0), 3 weeks after treatment initiation (T1), 12 weeks after treatment initiation between paclitaxel-based treatment and anthracycline regimens (T2), and after neoadjuvant chemotherapy before surgery (T3).
Supplementary Figure S2 from Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy
Authors: Magbanua Mark Jesus M. , Ahmed Ziad , Sayaman Rosalyn W. , Brown Swigart Lamorna , Hirst Gillian L. , Yau Christina , Wolf Denise M. , Li Wen , Delson Amy L. , Perlmutter Jane , Pohlmann Paula , Symmans W. Fraser , Yee Douglas , Hylton Nola M. , Esserman Laura J. , DeMichele Angela M. , Rugo Hope S. , van 't Veer Laura J.
Published: June 2024

CfDNA concentration in patients with HER2-negative breast cancers. CfDNA concentration was measured in the plasma of patients with hormone receptor-positive HER2-negative (HR+HER2-) and triple-negative breast cancer (TNBC). P values were calculated using the Wilcoxon rank sum test. Blood was collected at pretreatment (T0), 3 weeks after treatment initiation (T1), 12 weeks after treatment initiation between paclitaxel-based treatment and anthracycline regimens (T2), and after neoadjuvant chemotherapy before surgery (T3).
Supplementary Table S3 from Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC
Authors: Swiecicki Paul L. , Bellile Emily , Dragovic Aleksandar F. , McHugh Jonathan , Udager Aaron , Mierzwa Michelle Lynn , Shah Jennifer , Heft-Neal Molly , Rosko Andrew , Malloy Kelly M. , Casper Keith , Chinn Steven Bennett , Shuman Andrew G. , Stucken Chaz , Chepeha Douglas B. , Wolf Gregory T. , Bradford Carol Rossier , Eisbruch Avraham , Prince Mark E. , Worden Francis P. , Spector Matthew E.
Published: June 2024

Supplementary Table 3: Swallowing Function
Supplementary Video S4 from A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer
Authors: Zanoni Daniella K. , Demétrio De Souza França Paula , Valero Cristina , Peterson Gary , Ardigo Marco , Ghossein Ronald , Dusza Stephen W. , Matsuura Danielli , Scholfield Daniel W. , Adilbay Dauren , Montero Pablo H. , Migliacci Jocelyn , Pillarsetty Naga Vara Kishore , Kose Kivanc , Ganly Ian , Rajadhyaksha Milind , Patel Snehal G.
Published: June 2024

Supplementary Video S4 demonstrates irregular tissue pattern. Carcinoma comprise cells arranged in a disorganized and irregular pattern.
Supplementary Table S3 from A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer
Authors: Zanoni Daniella K. , Demétrio De Souza França Paula , Valero Cristina , Peterson Gary , Ardigo Marco , Ghossein Ronald , Dusza Stephen W. , Matsuura Danielli , Scholfield Daniel W. , Adilbay Dauren , Montero Pablo H. , Migliacci Jocelyn , Pillarsetty Naga Vara Kishore , Kose Kivanc , Ganly Ian , Rajadhyaksha Milind , Patel Snehal G.
Published: June 2024

Supplementary Table S3 shows the measures of association and effect for RCM features by presence/absence of tumor by H&E.
Supplementary Figure S9 from A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer
Authors: Zanoni Daniella K. , Demétrio De Souza França Paula , Valero Cristina , Peterson Gary , Ardigo Marco , Ghossein Ronald , Dusza Stephen W. , Matsuura Danielli , Scholfield Daniel W. , Adilbay Dauren , Montero Pablo H. , Migliacci Jocelyn , Pillarsetty Naga Vara Kishore , Kose Kivanc , Ganly Ian , Rajadhyaksha Milind , Patel Snehal G.
Published: June 2024

Supplementary Figure S9 shows in vivo RCM images of a tumor area in a 47-year-old male, never smoker and with no history of alcohol exposure, harboring a 1.5 cm leukoplastic lesion on his left lateral tongue.
Supplemental Figure 11 from GD2-Targeting CAR T-cell Therapy for Patients with GD2+ Medulloblastoma
Authors: Ciccone Roselia , Quintarelli Concetta , Camera Antonio , Pezzella Michele , Caruso Simona , Manni Simona , Ottaviani Alessio , Guercio Marika , Del Bufalo Francesca , Quadraccia Maria Cecilia , Orlando Domenico , Di Cecca Stefano , Sinibaldi Matilde , Aurigemma Mariasole , Iaffaldano Laura , Sarcinelli Andrea , D'Amore Maria Luisa , Ceccarelli Manuela , Nazio Francesca , Marabitti Veronica , Giorda Ezio , Pezzullo Marco , De Stefanis Cristiano , Carai Andrea , Rossi Sabrina , Alaggio Rita , Del Baldo Giada , Becilli Marco , Mastronuzzi Angela , De Angelis Biagio , Locatelli Franco
Published: June 2024

Supplemental Figure 11. Quantification of murine plasma neurofilament (NFL) levels in an orthotopic mouse model of the human DAOY-GFP cell line, treated with NT or CAR.GD2 T-cells.
Supplementary Figure S5 from A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer
Authors: Zanoni Daniella K. , Demétrio De Souza França Paula , Valero Cristina , Peterson Gary , Ardigo Marco , Ghossein Ronald , Dusza Stephen W. , Matsuura Danielli , Scholfield Daniel W. , Adilbay Dauren , Montero Pablo H. , Migliacci Jocelyn , Pillarsetty Naga Vara Kishore , Kose Kivanc , Ganly Ian , Rajadhyaksha Milind , Patel Snehal G.
Published: June 2024

Supplementary Figure S5 shows in vivo RCM images of a tumor area in an 84-year-old female patient, with a history of 2 packs of cigarettes per day for 65 years and no history of alcohol exposure, harboring a 3.2-cm infiltrating moderately differentiated oral squamous cell carcinoma of the right lateral tongue.
Supplementary Table S1 from The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer
Authors: Han Yoo Jane , Liu Siyao , Hardeman Ashley , Rajagopal Padma Sheila , Mueller Jeffrey , Khramtsova Galina , Sanni Ayodele , Ajani Mustapha , Clayton Wendy , Hurley Ian W. , Yoshimatsu Toshio F. , Zheng Yonglan , Parker Joel , Perou Charles M. , Olopade Olufunmilayo I.
Published: June 2024

Supplementary Table S1: The PAM110 Genes
Supplementary Figure S3 from The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer
Authors: Han Yoo Jane , Liu Siyao , Hardeman Ashley , Rajagopal Padma Sheila , Mueller Jeffrey , Khramtsova Galina , Sanni Ayodele , Ajani Mustapha , Clayton Wendy , Hurley Ian W. , Yoshimatsu Toshio F. , Zheng Yonglan , Parker Joel , Perou Charles M. , Olopade Olufunmilayo I.
Published: June 2024

Supplementary Fig. S3. An Association with MKI67, ESR1, or ERBB2 Expression.
Supplementary Figure S6 from IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
Authors: Moyer Cassandra L. , Lanier Amanda , Qian Jing , Coleman Darian , Hill Jamal , Vuligonda Vidyasagar , Sanders Martin E. , Mazumdar Abhijit , Brown Powel H.
Published: June 2024

Supplementary figure with additional cell line growth assays of drug combinations
Supplementary Table 7 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Authors: Carpenter Eileen S. , Kadiyala Padma , Elhossiny Ahmed M. , Kemp Samantha B. , Li Jay , Steele Nina G. , Nicolle Rémy , Nwosu Zeribe C. , Freeman Julia , Dai Henry , Paglia Daniel , Du Wenting , Donahue Katelyn , Morales Jacqueline , Medina-Cabrera Paola I. , Bonilla Monica E. , Harris Lindsey , The Stephanie , Gunchick Valerie , Peterson Nicole , Brown Kristee , Mattea Michael , Espinoza Carlos E. , McGue Jake , Kabala Sarah M. , Baliira Rachel K. , Renollet Nur M. , Mooney Ayden G. , Liu Jianhua , Bhalla Sean , Farida Jeremy P. , Ko Christopher , Machicado Jorge D. , Kwon Richard S. , Wamsteker Erik-Jan , Schulman Allison , Anderson Michelle A. , Law Ryan , Prabhu Anoop , Coulombe Pierre A. , Rao Arvind , Frankel Timothy L. , Bednar Filip , Shi Jiaqi , Sahai Vaibhav , Pasca Di Magliano Marina
Published: June 2024

Longitudinal Single Cell Sequencing PBMC Differentially Expressed Genes
Supplementary Table 10 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Authors: Carpenter Eileen S. , Kadiyala Padma , Elhossiny Ahmed M. , Kemp Samantha B. , Li Jay , Steele Nina G. , Nicolle Rémy , Nwosu Zeribe C. , Freeman Julia , Dai Henry , Paglia Daniel , Du Wenting , Donahue Katelyn , Morales Jacqueline , Medina-Cabrera Paola I. , Bonilla Monica E. , Harris Lindsey , The Stephanie , Gunchick Valerie , Peterson Nicole , Brown Kristee , Mattea Michael , Espinoza Carlos E. , McGue Jake , Kabala Sarah M. , Baliira Rachel K. , Renollet Nur M. , Mooney Ayden G. , Liu Jianhua , Bhalla Sean , Farida Jeremy P. , Ko Christopher , Machicado Jorge D. , Kwon Richard S. , Wamsteker Erik-Jan , Schulman Allison , Anderson Michelle A. , Law Ryan , Prabhu Anoop , Coulombe Pierre A. , Rao Arvind , Frankel Timothy L. , Bednar Filip , Shi Jiaqi , Sahai Vaibhav , Pasca Di Magliano Marina
Published: June 2024

Univariate and Multivariate Surivival Analysis of Locally Advanced and Metastatic PDAC Patients
Supplementary Fig 9 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Authors: Carpenter Eileen S. , Kadiyala Padma , Elhossiny Ahmed M. , Kemp Samantha B. , Li Jay , Steele Nina G. , Nicolle Rémy , Nwosu Zeribe C. , Freeman Julia , Dai Henry , Paglia Daniel , Du Wenting , Donahue Katelyn , Morales Jacqueline , Medina-Cabrera Paola I. , Bonilla Monica E. , Harris Lindsey , The Stephanie , Gunchick Valerie , Peterson Nicole , Brown Kristee , Mattea Michael , Espinoza Carlos E. , McGue Jake , Kabala Sarah M. , Baliira Rachel K. , Renollet Nur M. , Mooney Ayden G. , Liu Jianhua , Bhalla Sean , Farida Jeremy P. , Ko Christopher , Machicado Jorge D. , Kwon Richard S. , Wamsteker Erik-Jan , Schulman Allison , Anderson Michelle A. , Law Ryan , Prabhu Anoop , Coulombe Pierre A. , Rao Arvind , Frankel Timothy L. , Bednar Filip , Shi Jiaqi , Sahai Vaibhav , Pasca Di Magliano Marina
Published: June 2024

CXCL8-high tumor infiltrating granulocytes are marked by a pro-tumor gene signature.
Supplementary Fig 13 from KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Authors: Carpenter Eileen S. , Kadiyala Padma , Elhossiny Ahmed M. , Kemp Samantha B. , Li Jay , Steele Nina G. , Nicolle Rémy , Nwosu Zeribe C. , Freeman Julia , Dai Henry , Paglia Daniel , Du Wenting , Donahue Katelyn , Morales Jacqueline , Medina-Cabrera Paola I. , Bonilla Monica E. , Harris Lindsey , The Stephanie , Gunchick Valerie , Peterson Nicole , Brown Kristee , Mattea Michael , Espinoza Carlos E. , McGue Jake , Kabala Sarah M. , Baliira Rachel K. , Renollet Nur M. , Mooney Ayden G. , Liu Jianhua , Bhalla Sean , Farida Jeremy P. , Ko Christopher , Machicado Jorge D. , Kwon Richard S. , Wamsteker Erik-Jan , Schulman Allison , Anderson Michelle A. , Law Ryan , Prabhu Anoop , Coulombe Pierre A. , Rao Arvind , Frankel Timothy L. , Bednar Filip , Shi Jiaqi , Sahai Vaibhav , Pasca Di Magliano Marina
Published: June 2024

Plasma CXCL8 levels correlate with worse overall survival.
Supplementary Table S4 from Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Authors: Jamieson Amy , Sobral de Barros Juliana , Cochrane Dawn R. , Douglas J. Maxwell , Shankar Sameer , Lynch Branden J. , Leung Samuel , Martin Spencer , Senz Janine , Lum Amy , Drew Yvette , Gilks C. Blake , Huntsman David G. , McAlpine Jessica N.
Published: June 2024

Supplemental Table 4: Ploidy calls by Rascal and FISH
Supplementary Figure S4 from Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Authors: Jamieson Amy , Sobral de Barros Juliana , Cochrane Dawn R. , Douglas J. Maxwell , Shankar Sameer , Lynch Branden J. , Leung Samuel , Martin Spencer , Senz Janine , Lum Amy , Drew Yvette , Gilks C. Blake , Huntsman David G. , McAlpine Jessica N.
Published: June 2024

Supplemental figure 4. Plot summarizing the relationship between Vancouver signature exposures per sample, copy number status and targeted panel mutations for key HRD genes.
Supplementary Figure S2 from Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Authors: Jamieson Amy , Sobral de Barros Juliana , Cochrane Dawn R. , Douglas J. Maxwell , Shankar Sameer , Lynch Branden J. , Leung Samuel , Martin Spencer , Senz Janine , Lum Amy , Drew Yvette , Gilks C. Blake , Huntsman David G. , McAlpine Jessica N.
Published: June 2024

Supplemental Figure 2. Oncoplot of HR associated genes.
Supplementary Table 6 from Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase–Deficient Renal Cell Carcinoma
Authors: Chen Junru , Hu Xu , Zhao Junjie , Yin Xiaoxue , Zheng Linmao , Guo Jingjing , Chen Jianhui , Wang Yongquan , Sheng Xinan , Dong Haiying , Liu Xiaodong , Zhang Xingming , Liang Jiayu , Liu Haolin , Yao Jin , Liu Jiyan , Shen Yali , Chen Zhibin , He Zhengyu , Wang Yaodong , Chen Ni , Nie Ling , Zhang Mengni , Pan Xiuyi , Chen Yuntian , Liu Haoyang , Zhang Yaowen , Tang Yanfeng , Zhu Sha , Zhao Jinge , Dai Jindong , Wang Zilin , Zeng Yuhao , Wang Zhipeng , Huang Haojie , Liu Zhenhua , Shen Pengfei , Zeng Hao , Sun Guangxi
Published: June 2024

Supplementary Table 6. Clinical and molecular features of tumor samples used in the single-cell RNA analysis.
Supplementary Table S2 from Preclinical Efficacy of a PSMA-Targeted Actinium-225 Conjugate (225Ac-Macropa-Pelgifatamab): A Targeted Alpha Therapy for Prostate Cancer
Authors: Schatz Christoph A. , Zitzmann-Kolbe Sabine , Moen Ingrid , Klotz Monika , Nair Shankari , Stargard Stefan , Bjerke Roger M. , Wickstrøm Biseth Katrine , Feng Yuan Zeng , Indrevoll Bård , Cruciani Veronique , Karlsson Jenny , Haendler Bernard , Nielsen Carsten H. , Alfsen Maria Z. , Hammer Stefanie , Hennekes Hartwig , Cuthbertson Alan , Hagemann Urs B. , Larsen Åsmund
Published: June 2024

Table S2. Antibodies used in detection of PSMA expression and induction of markers of DNA damage.
Supplementary Figure S1 from Preclinical Efficacy of a PSMA-Targeted Actinium-225 Conjugate (225Ac-Macropa-Pelgifatamab): A Targeted Alpha Therapy for Prostate Cancer
Authors: Schatz Christoph A. , Zitzmann-Kolbe Sabine , Moen Ingrid , Klotz Monika , Nair Shankari , Stargard Stefan , Bjerke Roger M. , Wickstrøm Biseth Katrine , Feng Yuan Zeng , Indrevoll Bård , Cruciani Veronique , Karlsson Jenny , Haendler Bernard , Nielsen Carsten H. , Alfsen Maria Z. , Hammer Stefanie , Hennekes Hartwig , Cuthbertson Alan , Hagemann Urs B. , Larsen Åsmund
Published: June 2024

Figure S1. 225Ac-pelgi induces the phosphorylation of DNA damage markers in LNCaP, C4-2, and
22Rv1 prostate cancer cells
Supplementary Figure S9 from Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk
Authors: Silver Alexander J. , Vlasschaert Caitlyn , Mack Taralynn , Sharber Brian , Xu Yaomin , Bick Alexander G. , Pinson C. Wright , Savona Michael R.
Published: June 2024

Supplementary Figure S9. Similar allograft organ distributions among those evaluated for incident complications.
Supplementary Figure S4 from Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk
Authors: Silver Alexander J. , Vlasschaert Caitlyn , Mack Taralynn , Sharber Brian , Xu Yaomin , Bick Alexander G. , Pinson C. Wright , Savona Michael R.
Published: June 2024

Supplementary Figure S4. Analysis of CHIP with large variant allele fraction.
Supplementary Table S10 from Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study
Authors: Pinato David J. , D'Alessio Antonio , Fulgenzi Claudia Angela Maria , Schlaak Alexandra Emilia , Celsa Ciro , Killmer Saskia , Blanco Jesus Miguens , Ward Caroline , Stikas Charalampos-Vlasios , Openshaw Mark R. , Acuti Nicole , Nteliopoulos Georgios , Balcells Cristina , Keun Hector C. , Goldin Robert D. , Ross Paul J. , Cortellini Alessio , Thomas Robert , Young Anna-Mary , Danckert Nathan , Tait Paul , Marchesi Julian R. , Bengsch Bertram , Sharma Rohini
Published: June 2024

Supplementary Table 10.
Baseline characteristics of patients included in the metabolomics analysis.
Supplementary Methods S7 from Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study
Authors: Pinato David J. , D'Alessio Antonio , Fulgenzi Claudia Angela Maria , Schlaak Alexandra Emilia , Celsa Ciro , Killmer Saskia , Blanco Jesus Miguens , Ward Caroline , Stikas Charalampos-Vlasios , Openshaw Mark R. , Acuti Nicole , Nteliopoulos Georgios , Balcells Cristina , Keun Hector C. , Goldin Robert D. , Ross Paul J. , Cortellini Alessio , Thomas Robert , Young Anna-Mary , Danckert Nathan , Tait Paul , Marchesi Julian R. , Bengsch Bertram , Sharma Rohini
Published: June 2024

Supplementary Methods 7. Primary annotations and related number of genes profiled using the NanoString PanCancer Immune panel.
Supplementary Figure 4 from Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation
Authors: Rolfo Christian D. , Madison Russell W. , Pasquina Lincoln W. , Brown Derek W. , Huang Yanmei , Hughes Jason D. , Graf Ryon P. , Oxnard Geoffrey R. , Husain Hatim
Published: June 2024

Supplementary Figure 4: Positive percent agreement (PPA) and negative predictive value (NPV) of liquid biopsy collected no more than 90 days after tissue biopsy.
Data from Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Authors: Makhlin Igor , Demissei Biniyam G. , D'Agostino Ralph , Hundley W. Greg , Baleanu-Gogonea Camelia , Wilcox Nicholas S. , Chen Anna , Smith Amanda M. , O'Connell Nathaniel Sean , Januzzi James L. , Lesser Glenn J. , Scherrer-Crosbie Marielle , Ibáñez Borja , Tang W.H. Wilson , Ky Bonnie
Published: June 2024

AbstractPurpose:
Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of atorvastatin on oxidative and nitrosative stress biomarkers, and explored whether these biomarkers could explain the lack of effect of atorvastatin on LVEF (left ventricular ejection fraction) in PREVENT.
Patients and Methods:
Blood samples were collected and cardiac MRI was performed before doxorubicin initiation and at 6 and 24 months. Thirteen biomarkers [arginine–nitric oxide metabolites, paraoxonase-1 (PON-1) activity, and myeloperoxidase] were measured. Dimensionality reduction using principal component analysis was used to define biomarker clusters. Linear mixed-effects models determined the changes in biomarkers over time according to treatment group. Mediation analysis determined whether biomarker clusters explained the lack of effect of atorvastatin on LVEF.
Results:
Among 202 participants with available biomarkers, median age was 53 years; 86.6% had breast cancer; median LVEF was 62%. Cluster 1 levels, reflecting arginine methylation metabolites, were lower over time with atorvastatin, although this was not statistically significant (P = 0.081); Cluster 2 levels, reflecting PON-1 activity, were significantly lower with atorvastatin (P = 0.024). There were no significant changes in other biomarker clusters (P > 0.05). Biomarker clusters did not mediate an effect of atorvastatin on LVEF (P > 0.05).
Conclusions:
Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.
Data from Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Authors: Jamieson Amy , Sobral de Barros Juliana , Cochrane Dawn R. , Douglas J. Maxwell , Shankar Sameer , Lynch Branden J. , Leung Samuel , Martin Spencer , Senz Janine , Lum Amy , Drew Yvette , Gilks C. Blake , Huntsman David G. , McAlpine Jessica N.
Published: June 2024

AbstractPurpose:
Shallow whole-genome sequencing (sWGS) can detect copy-number (CN) aberrations. In high-grade serous ovarian cancer (HGSOC) sWGS identified CN signatures such as homologous recombination deficiency (HRD) to direct therapy. We applied sWGS with targeted sequencing to p53abn endometrial cancers to identify additional prognostic stratification and therapeutic opportunities.
Experimental Design:
sWGS and targeted panel sequencing was performed on formalin-fixed, paraffin-embedded p53abn endometrial cancers. CN alterations, mutational data and CN signatures were derived, and associations to clinicopathologic and outcomes data were assessed.
Results:
In 187 p53abn endometrial cancers, 5 distinct CN signatures were identified. Signature 5 was associated with BRCA1/2 CN loss with features similar to HGSOC HRD signature. Twenty-two percent of potential HRD cases were identified, 35 patients with signature 5, and 8 patients with BRCA1/2 somatic mutations. Signatures 3 and 4 were associated with a high ploidy state, and CCNE1, ERBB2, and MYC amplifications, with mutations in PIK3CA enriched in signature 3. We observed improved overall survival (OS) for patients with signature 2 and worse OS for signatures 1 and 3. Twenty-eight percent of patients had CCNE1 amplification and this subset was enriched with carcinosarcoma histotype. Thirty-four percent of patients, across all histotypes, had ERBB2 amplification and/or HER2 overexpression on IHC, which was associated with worse outcomes. Mutations in PPP2R1A (29%) and FBXW7 (16%) were among the top 5 most common mutations.
Conclusions:
sWGS and targeted sequencing identified therapeutic opportunities in 75% of patients with p53abn endometrial cancer. Further research is needed to determine the efficacy of treatments targeting these identified pathways within p53abn endometrial cancers.
Data from A Signal-Finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration–Resistant Prostate Cancer: Results from CYCLONE 1
Authors: Agarwal Neeraj , Castellano Daniel , Alonso-Gordoa Teresa , Arranz Arija Jose Angel , Colomba Emeline , Gravis Gwenaelle , Mourey Loic , Oudard Stephane , Fléchon Aude , González Macarena , Rey Pablo M. , Schweizer Michael T. , Gallardo Enrique , Johnston Erica , Balar Arjun , Haddad Nadine , Appiah Adams K. , Nacerddine Karim , Piulats José M.
Published: June 2024

AbstractPurpose:
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in breast cancer, androgen receptor signaling activates cyclin D–CDK4/6, driving proliferation and resistance to hormonal manipulation in prostate cancer. This study was designed to detect signals of clinical activity for abemaciclib in treatment-refractory metastatic castration-resistant prostate cancer (mCRPC).
Patients and Methods:
Eligible patients had progressive mCRPC, measurable disease, and previously received ≥1 novel hormonal agent(s) and 2 lines of taxane chemotherapy. Abemaciclib 200 mg twice daily was administered on a continuous dosing schedule. Primary endpoint was objective response rate (ORR) without concurrent bone progression. This study was designed to detect a minimum ORR of 12.5%.
Results:
At trial entry, 40 (90.9%) of 44 patients had objective radiographic disease progression, 4 (9.1%) had prostate-specific antigen (PSA)–only progression, and 20 (46.5%) had visceral metastases (of these, 60% had liver metastases). Efficacy analyses are as follows: ORR without concurrent bone progression: 6.8%; disease control rate: 45.5%; median time to PSA progression: 6.5 months [95% confidence interval (CI), 3.2–NA]; median radiographic PFS; 2.7 months (95% CI, 1.9–3.7); and median OS, 8.4 months (95% CI, 5.6–12.7). Most frequent grade ≥3 treatment-emergent adverse events (AE) were neutropenia (25.0%), anemia, and fatigue (11.4% each). No grade 4 or 5 AEs were related to abemaciclib.
Conclusions:
Abemaciclib monotherapy was well tolerated and showed clinical activity in this heavily pretreated population, nearly half with visceral metastases. This study is considered preliminary proof-of-concept and designates CDK4/6 as a valid therapeutic target in prostate cancer.
Uncropped Western Blots from Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy
Authors: Kazansky Yaniv , Cameron Daniel , Mueller Helen S. , Demarest Phillip , Zaffaroni Nadia , Arrighetti Noemi , Zuco Valentina , Kuwahara Yasumichi , Somwar Romel , Ladanyi Marc , Qu Rui , de Stanchina Elisa , Dela Cruz Filemon S. , Kung Andrew L. , Gounder Mrinal M. , Kentsis Alex
Published: June 2024

Uncropped images of all western blots used in this study.