bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing and Understanding HGNN Training on GPUs
Authors: Han Dengke , Yan Mingyu , Ye Xiaochun , Fan Dongrui
Published: November 2024

Owing to their remarkable representation capabilities for heterogeneous graph data, Heterogeneous Graph Neural Networks (HGNNs) have been widely adopted in many critical real-world domains such as recommendation systems and medical analysis. Prior to their practical application, identifying the optimal HGNN model parameters tailored to specific tasks through extensive training is a time-consuming and costly process. To enhance the efficiency of HGNN training, it is essential to characterize and analyze the execution semantics and patterns within the training process to identify performance bottlenecks. In this study, we conduct a comprehensive quantification and in-depth analysis of two mainstream HGNN training scenarios, including single-GPU and multi-GPU distributed training. Based on the characterization results, we reveal the performance bottlenecks and their underlying causes in different HGNN training scenarios and propose optimization guidelines from both software and hardware perspectives.
Ferroptosis‐Related LncRNA BCRP3 Promotes the Proliferation and Migration of Prostate Cancer
Authors: Zhou Peng , Gu Yueying , Zhao Wenchao , Wang Hui , Gu Junhua , Xu Zhen , Jin Xin
Published: November 2024

Background: Long noncoding RNAs (lncRNAs) are reported that play an important role in regulating tumorigenesis. This study aims to develop a ferroptosis‐related lncRNA gene signature for predicting biochemical recurrence of prostate cancer (PCa) and prove a functional lncRNA BCRP3 as a promotor toward PCa progression.

Methods: The ferroptosis‐related lncRNA were identified by interoperating the databases of The Cancer Genome Atlas (TCGA) and FerrDb. A predictive model for biochemical recurrence of PCa was established based on the LASSO Cox regression. Kaplan–Meier cures were applied in the measurement of the impact on patients’ survival caused by key lncRNAs. Meanwhile, the molecular assays of CCK8, EdU, wound healing, and Transwell were conducted to evaluate the tumor‐suppressive effect of BCRP3 in vitro.

Results: This study presented that 17 differentially expressed ferroptosis‐related lncRNAs were confirmed and further screened out 9 key lncRNAs for the establishment of risk model. The nomogram involved the risk model was also proved with an excellent predictive performance toward 1‐, 3‐, and 5‐year survival with the area of curves (AUC) as 0.77, 0.79, and 0.65 separately. Notably, the lncRNA BCRP3 was significantly correlated with the survival of PCa patients based on multivariate Cox regression. Additionally, downregulation of BCRP3 effectively inhibited the proliferation, migration, and invasion of PC3 cells which further proved its anti‐tumor function.

Conclusion: We developed a ferroptosis‐related lncRNA risk model for predicting biochemical recurrence, which assisting in the clinical therapy of patients with PCa.
Intrapartum and 30‐Day Postpartum Complications in Patients With Antenatal COVID‐19 Infection: A Retrospective Cohort Study
Authors: Donthi Sriya , Kloos Jacqueline , Gibson Kelly S. , Olson Danielle , Kaelber David C.
Published: November 2024

Objective: The study was aimed at comparing intrapartum and postpartum outcomes between pregnant patients with and without antenatal COVID‐19 infection using aggregated, deidentified electronic health record (EHR) data.

Design and Setting: This retrospective cohort study included data from over 80 health care organizations within the TriNetX Analytics Research Network.

Population: Individuals admitted for delivery from Jan 2020 to May 2023 were studied.

Methods: We studied individuals with ICD‐10 codes for delivery, COVID‐19 diagnosis, and primary outcomes. We compared the incidence of adverse intrapartum and 30‐day postpartum outcomes in those with and without antenatal COVID‐19.

Main Outcome Measures: The main outcomes compared were obstetric, cardiovascular, neurovascular, and respiratory outcomes within 30 days postpartum.

Results: Twenty‐six thousand nine hundred seventy‐four of 369,923 (7%) birthing parents with a delivery encounter had an antenatal COVID‐19 diagnosis. Compared to matched controls, having COVID‐19 was associated with an increased risk of postpartum hemorrhage (RR—1.24 (CI—1.16–1.33)), gestational hypertension (RR—1.27 (CI—1.27–1.34)), preeclampsia (RR—1.25 (CI—1.18–1.32)), eclampsia (RR—1.66 (CI—1.29–2.32)), preterm labor (RR—1.21 (CI—1.21–1.34)), cerebral infarction (RR—1.74 (CI—1.04–2.90)), cardiomyopathy (RR—2.08 (CI—1.30–3.32)), heart failure (RR—1.55 (CI—1.04–2.31)), sepsis (RR—2.21 (CI—1.54–3.19)), DVT (RR—2.32 (CI—1.45–3.71)), and pulmonary embolism (RR—2.68 (CI—1.74–2.90)).

Conclusion: Individuals with antenatal COVID‐19 were more likely to have intrapartum and postpartum obstetric, cardiovascular, neurovascular, and respiratory complications. This data will inform risk stratification and screening for prenatal care providers.
Neuroprotective Effect of Benzyl Ferulate on Ischemia/Reperfusion Injury via Regulating NOX2 and NOX4 in Rats
Authors: Xiang Yu , Mao Li , Dai Zhao-Hui , Liu Xiao-Hua , Yang Zhong-Bao
Published: November 2024

Oxidative stress is a primary contributor to cerebral ischemia/reperfusion (CI/R) injury, and the use of antioxidants represents a crucial therapeutic strategy for managing CI/R injury. This study aims to explore the antioxidant effects of benzyl ferulate on CI/R injury and elucidate its underlying mechanisms. In vivo models of CI/R injury and hypoxia/reoxygenation (H/R) injury in SH‐SY5Y cells were established, followed by treatment with benzyl ferulate. The extent of oxidative stress was assessed through evaluations of neurobiological function, cerebral infarct volume, reactive oxygen species (ROS), apoptosis levels, etc. Results indicated that benzyl ferulate significantly downregulated the expression of NADPH oxidase 2 (NOX) 2/NOX4 while upregulating miRNAs (652/532/92b) in CI/R rats or SH‐SY5Y cells. It also reduced total NOX enzyme activity, enhanced superoxide dismutase (SOD) activity, decreased ROS and malondialdehyde (MDA) production, and inhibited cleaved caspase‐3 and Bax expression—ultimately leading to reduced cell apoptosis. Benzyl ferulate effectively mitigates oxidative stress injuries of middle cerebral artery occlusion (MCAO) rats or SH‐SY5Y cells subjected to H/R, and its mechanism appears to involve modulation of the miRNAs (652/532/92b)/NOX2/4 axis. This study first proved that benzyl ferulate is a promising antioxidant candidate for treating CI/R injury.
Long‐Term Survival of Mitroflow and Perimount Aortic Valve Replacements
Authors: Krasniqi Lytfi , Dahl Jordi Sanchez , Jensen Christian Greve , Mortensen Poul Erik , Brandes Axel , Gerke Oke , Ravn Emil Johannes , Poulsen Viktor , Riber Lars Peter Schødt
Published: November 2024

Objectives: The American College of Cardiology (ACC) guidelines recommend the same imaging frequency for all bioprosthetic valves, but some have demonstrated poor durability. We aimed to assess mortality differences between small (19–21 mm) and large (23–29 mm) in Mitroflow and Carpentier‐Edwards Perimount aortic valves.

Methods: A retrospective observational study was conducted by all patients undergoing isolated surgical aortic valve replacement with Mitroflow or Perimount in Western Denmark between 1999 and 2014 and followed until January 2024. The primary endpoint was all‐cause mortality. Secondary endpoints were cardiovascular mortality and sudden cardiac death. A propensity score‐matched analysis was performed.

Results: A total of 1150 patients were analyzed, with 496 (43%) receiving Mitroflow valves and 654 (57%) receiving Perimount valves. In the Mitroflow group, 108 (22%) had a valve size of 19–21 mm, and 388 (78%) in the size range of 23–29 mm. In the Perimount group, the distribution was 99 (15%) and 555 (85%), respectively. The compromised survival of Mitroflow valves was attributed to the valve type, regardless of the valve sizes. Larger Mitroflow valves exhibited the same compromised late mortality as smaller valves, 66.7% vs 61.5%, respectively (p = 0.95). The same pattern of mortality was observed in the matched population, with Perimount demonstrating significant lower risk of mortality.

Conclusion: Mitroflow valves were associated with a poorer prognosis compared to Perimount valves. Additionally, larger Mitroflow valves were not associated with an improved prognosis compared to smaller valve sizes. EuroSCORE2 had a significant impact on patient survival.
Association of Dietary Flavonoids Intake With All‐Cause and Cardiovascular Disease Mortality in Diabetic Kidney Disease: A Cohort Study From the NHANES Database
Authors: Wang Qian , Deng Weizhu , Yang Jian , Li Yaqing , Huang Hui , Luo Yayong , Li Zhongxia , Dong Zheyi
Published: November 2024

The relationship between dietary flavonoid intake and mortality in the diabetic kidney disease (DKD) population is unknown. So this study is aimed at investigating the association of total dietary flavonoid intake and their subclasses with all‐cause and cardiovascular disease (CVD) mortality. Data of this cohort study were extracted from the NHANES (2007–2010 and 2017–2018). The survival status of participants was determined by linking to the National Death Index through the end of 2019. Flavonoid intake was measured using two 24‐h dietary recall interviews. The Kaplan–Meier curves and weighted Cox proportional hazard regression models were used to assess the effect of dietary flavonoid intake on CVD and all‐cause mortality, with adjustments for multiple covariates. A total of 1155 participants were included for analysis. After a median follow‐up of 76.36 (S.E: 3.24) months, 409 participants died of all‐cause mortality, of which 138 died of CVD. In the fully adjusted model, higher total dietary flavonoids intake (HR = 0.69, 95% CI: 0.52–0.92) was associated with lower all‐cause mortality and subclasses of higher flavones (HR = 0.60, 95% CI: 0.35–0.85) was also with lower all‐cause mortality. In subclasses of flavonoids, higher intake of both anthocyanidins (HR = 0.54, 95% CI: 0.28 to 0.87) and flavones (HR = 0.50, 95% CI: 0.28–0.87) were associated with lower odds of CVD mortality. Higher flavonoid intake was associated with a reduced risk of CVD and all‐cause mortality in DKD. Higher flavonoid intake provides a potential opportunity to improve the prognosis of DKD. And future research into the mechanisms between flavonoids and mortality is needed.
Some Approximation Properties of the (p, q)–Stancu–Schurer–Bleimann–Butzer–Hahn Operators
Authors: Torun Gülten
Published: November 2024

In this article, the (p, q)–Stancu–Schurer–Bleimann–Butzer–Hahn ((p, q)‐SSBBH) operators are introduced. The Korovkin‐type theorem is obtained to show the approximation properties of these operators. Then, the rate of convergence of these operators with the help of the modulus of continuity and Lipschitz‐type maximal functions is calculated, respectively. Finally, for the asymptotic behavior of these operators, the Voronovskaja‐type theorem is given. Furthermore, the convergence of these operators to the considered function f by plotting the graphs is demonstrated. And, this convergence is compared with the convergence of the (p, q)–Bleimann–Butzer–Hahn ((p, q)‐BBH) operators to the same function.
Fabrication and Compression Properties of Reinforced Epoxy Syntactic Foam With Basalt Fiber
Authors: Cao Shuai , Jiang Tao , Shi Shanshan , Gui Xiaofan , Wang Ying , Tang Bo , Xiang Lixue , Dai Xuming , Lin Donghai , Zhong Ning , Li Wenge , Yu Jinhong , Wu Xinfeng
Published: November 2024

Deep‐sea equipment is generally made of lightweight and pressure‐resistant materials in order to meet the requirements of the actual work. In order to explore marine resources better, it is necessary to research lightweight buoyancy materials for loading on mining equipment. These buoyancy materials contribute not only to providing adequate buoyancy to the mining equipment but also to reducing economic expenses. In this paper, hollow glass microspheres reinforced epoxy hollow spheres (HGMSs‐EHSs) were prepared by the rolling ball method using expanded polystyrene (EPS), epoxy resin (EP), and HGMS as raw materials. Epoxy syntactic foam (ESF) was manufactured by blending EP, curing agent, HGMS, and HGMS‐EHS with molding method. Basalt fiber (BF) reinforced ESF was fabricated by adding BFs to form a fiber network inside the syntactic foam. The results revealed that the density and compressive strength of ESF increased progressively with the number of HGMS‐EHS layers. The density and compressive strength of ESF decreased prospectively with the increase of the stacking volume fraction of HGMS‐EHS. The density and compressive strength of ESF increased gradually with the enlargement of the length and content of BF. In the range of influencing factors mentioned above, the density of ESF remains around 0.3 g/cm3, which has a low density. When the number of layers of HGMS‐EHS was two, the stacking volume fraction was 90%, the length of BF was 12 mm, the content of BF was 4%, the density of BF‐ESF was 0.316 g/cm3, and the compressive strength was 6.93 MPa. The compressive strength of prepared buoyancy material can meet the pressure resistance requirements for operations in waters of a certain depth. With a density of only 0.316 g/cm3, it provides sufficient buoyancy to balance the gravity of the equipment. Compared with the current study, in this paper, BFs were used as the reinforcing phase to prepare solid buoyancy foam with low density and high compressive strength. The experimental results demonstrate that this economical fiber material can effectively improve the compressive strength of buoyancy materials. This buoyancy material may be suitable for loading on small equipment for extracting marine resources. This work provides a reference for the preparation of low‐density solid buoyancy materials.
Supplementary Figure S1 from The Genomic Landscape of Benign and Malignant Thyroid Tumors from Individuals Carrying Germline PTEN Variants Is Distinct from Sporadic Thyroid Cancers
Authors: Plitt Gilman , Brewer Takae , Yehia Lamis , Rabinowitz Laura , Griffith Christopher C. , Eng Charis
Published: November 2024

Comparison of TMB in PHTS-associated thyroid tumors and sporadic PTC from TCGA
Supplementary Table S5 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S5
Supplemental Figure 6 from Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A.
Published: November 2024

YES1 inhibition improves taxane efficacy in resistant TNBC in vitro.
Supplemental Figure 4 from Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A.
Published: November 2024

YES1 is essential for microtubule function and centrosome homeostasis in SUM159 cells.
Figure S4 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Figure S4 and it's legend
Figure S2 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Figure S2 and it's legend
Table S5 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Table S5
Table S2 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Table S2
Figure S7 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Figure S7
Figure S6 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Figure S6
Figure S4 from Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
Authors: Becker Jeffrey H. , Metropulos Anastasia E. , Spaulding Christina , Marinelarena Alejandra M. , Shields Mario A. , Principe Daniel R. , Pham Thao D. , Munshi Hidayatullah G.
Published: November 2024

Effect of the combination of MRTX1133 and Venetoclax on the weights of tumor-bearing mice.
Figure S4 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Figure S4
Figure S2 from Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
Authors: Becker Jeffrey H. , Metropulos Anastasia E. , Spaulding Christina , Marinelarena Alejandra M. , Shields Mario A. , Principe Daniel R. , Pham Thao D. , Munshi Hidayatullah G.
Published: November 2024

PDAC cells grown on 2D tissue culture plastic exhibit increased sensitivity to MRTX1133 in ‘low’ confluent than in ‘high’ confluent 2D cultures.
Figure S9 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Authors: Liu Xiaoli , Chen Bonan , Xie Fuda , Wong Kit Yee , Cheung Alvin H.K. , Zhang Jinglin , Wu Qian , Fang Canbin , Hu Jintao , Wang Shouyu , Xu Dazhi , Chen Jianwu , Wang Yuzhi , Wong Chi Chun , Chen Huarong , Wu William K.K. , Yu Jun , Chan Michael W.Y. , Tsang Chi Man , Lo Kwok Wai , Tse Gary M.K. , To Ka-Fai , Kang Wei
Published: November 2024

Supplementary Figure S9
Figure S5 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Authors: Liu Xiaoli , Chen Bonan , Xie Fuda , Wong Kit Yee , Cheung Alvin H.K. , Zhang Jinglin , Wu Qian , Fang Canbin , Hu Jintao , Wang Shouyu , Xu Dazhi , Chen Jianwu , Wang Yuzhi , Wong Chi Chun , Chen Huarong , Wu William K.K. , Yu Jun , Chan Michael W.Y. , Tsang Chi Man , Lo Kwok Wai , Tse Gary M.K. , To Ka-Fai , Kang Wei
Published: November 2024

Supplementary Figure S5
Supplementary Video S2 from Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
Authors: Jiao Meng , Pirozzi Christopher J. , Yu Chen , Bao Xuhui , Hu Mengjie , Pan Dong , Littleton Sejiro , Reynolds Nathan , Saban Daniel R. , Li Fang , Li Chuan-Yuan
Published: November 2024

Supplementary Video S2
Figure S4 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Authors: Liu Xiaoli , Chen Bonan , Xie Fuda , Wong Kit Yee , Cheung Alvin H.K. , Zhang Jinglin , Wu Qian , Fang Canbin , Hu Jintao , Wang Shouyu , Xu Dazhi , Chen Jianwu , Wang Yuzhi , Wong Chi Chun , Chen Huarong , Wu William K.K. , Yu Jun , Chan Michael W.Y. , Tsang Chi Man , Lo Kwok Wai , Tse Gary M.K. , To Ka-Fai , Kang Wei
Published: November 2024

Supplementary Figure S4
Figure S14 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Authors: Liu Xiaoli , Chen Bonan , Xie Fuda , Wong Kit Yee , Cheung Alvin H.K. , Zhang Jinglin , Wu Qian , Fang Canbin , Hu Jintao , Wang Shouyu , Xu Dazhi , Chen Jianwu , Wang Yuzhi , Wong Chi Chun , Chen Huarong , Wu William K.K. , Yu Jun , Chan Michael W.Y. , Tsang Chi Man , Lo Kwok Wai , Tse Gary M.K. , To Ka-Fai , Kang Wei
Published: November 2024

Supplementary Figure S14
Supplementary Table 1 from H3K18 Lactylation Potentiates Immune Escape of Non–Small Cell Lung Cancer
Authors: Zhang Cai , Zhou Lijie , Zhang Mingyuan , Du Yue , Li Cai , Ren Huijun , Zheng Lu
Published: November 2024

Patient information
Data from H3K18 Lactylation Potentiates Immune Escape of Non–Small Cell Lung Cancer
Authors: Zhang Cai , Zhou Lijie , Zhang Mingyuan , Du Yue , Li Cai , Ren Huijun , Zheng Lu
Published: November 2024

Abstract
Recently discovered epigenetic modification lysine lactylation contributes to tumor development and progression in several types of cancer. In addition to the tumor-intrinsic effects, histone lactylation may mediate tumor microenvironment remodeling and immune evasion. In this study, we observed elevated pan–lysine lactylation and histone H3 lysine 18 lactylation (H3K18la) levels in non–small cell lung cancer (NSCLC) tissues, which was positively correlated with poor patient prognosis. Interruption of glycolysis by 2-deoxy-D-glucose and oxamate treatment and silencing of lactate dehydrogenase A and lactate dehydrogenase B reduced H3K18la levels and circumvented immune evasion of NSCLC cells by enhancing CD8+ T-cell cytotoxicity. Mechanistically, H3K18la directly activated the transcription of pore membrane protein 121 (POM121), which enhanced MYC nuclear transport and direct binding to the CD274 promoter to induce PD-L1 expression. In a mouse NSCLC xenograft model, combination therapy with a glycolysis inhibitor and an anti-PD-1 antibody induced intratumoral CD8+ T-cell function and exhibited strong antitumor efficacy. Overall, this work revealed that H3K18la potentiates the immune escape of NSCLC cells by activating the POM121/MYC/PD-L1 pathway, which offers insights into the role of posttranslational modifications in carcinogenesis and provides a rationale for developing an epigenetic-targeted strategy for treating NSCLC.

Significance: H3K18 lactylation supports immunosuppression in non-small cell lung cancer by inducing POM121 to increase MYC activity and PD-L1 expression, which can be reversed by metabolic reprogramming and immunotherapy treatment.
FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma
Authors: Jessa Selin , De Cola Antonella , Chandarana Bhavyaa , McNicholas Michael , Hébert Steven , Ptack Adam , Faury Damien , Tsai Jessica W. , Korshunov Andrey , Phoenix Timothy N. , Ellezam Benjamin , Jones David T.W. , Taylor Michael D. , Bandopadhayay Pratiti , Pathania Manav , Jabado Nada , Kleinman Claudia L.
Published: November 2024

Central nervous system neuroblastoma with forkhead box R2 (FOXR2) activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and glial markers, leading to frequent misdiagnoses, and limited information exists on the role of FOXR2 in their genesis. To identify their cellular origins, we profiled the transcriptomes of NB-FOXR2 tumors at the bulk and single-cell levels and integrated these profiles with large single-cell references of the normal brain. NB-FOXR2 tumors mapped to LHX6+/DLX+ lineages derived from the medial ganglionic eminence, a progenitor domain in the ventral telencephalon. In vivo prenatal Foxr2 targeting to the ganglionic eminences in mice induced postnatal cortical tumors recapitulating human NB-FOXR2–specific molecular signatures. Profiling of FOXR2 binding on chromatin in murine models revealed an association with ETS transcriptional networks, as well as direct binding of FOXR2 at key transcription factors that coordinate initiation of gliogenesis. These data indicate that NB-FOXR2 tumors originate from LHX6+/DLX+ interneuron lineages, a lineage of origin distinct from that of other FOXR2-driven brain tumors, highlight the susceptibility of ventral telencephalon–derived interneurons to FOXR2-driven oncogenesis, and suggest that FOXR2-induced activation of glial programs may explain the mixed neuronal and oligodendroglial features in these tumors. More broadly, this work underscores systematic profiling of brain development as an efficient approach to orient oncogenic targeting for in vivo modeling, critical for the study of rare tumors and development of therapeutics.

Significance: Profiling the developing brain enabled rationally guided modeling of FOXR2-activated CNS neuroblastoma, providing a strategy to overcome the heterogeneous origins of pediatric brain tumors that hamper tumor modeling and therapy development.

See related commentary by Orr, p. 195
Intestinal Subtype as a Biomarker of Response to Neoadjuvant Immunochemotherapy in Locally Advanced Gastric Adenocarcinoma: Insights from a Prospective Phase II Trial
Authors: Wang Lei , Sun Mengting , Li Jinyang , Wan Linghong , Tan Yuting , Tian Shuoran , Hou Yongying , Wu Linyu , Peng Ziyi , Hu Xiao , Zhang Qihua , Huang Zening , Han Mengyi , Peng Shiyin , Pan Yuwei , Ren Yuanfeng , Zhang Mengsi , Chen Dongfeng , Liu Qin , Li Xianfeng , Qin Zhong-yi , Xiang Junyv , Li Mengxia , Zhu Jianwu , Chen Qiyue , Luo Huiyan , Wang Shunan , Wang Tao , Li Fan , Bian Xiu-wu , Wang Bin
Published: November 2024

Purpose:

Neoadjuvant immunochemotherapy (NAIC) markedly induces pathologic regression in locally advanced gastric adenocarcinoma. However, specific biomarkers are still lacking to effectively identify the beneficiary patients for NAIC.

Patients and Methods:

A prospective, single-arm, phase II study was conducted to treat locally advanced gastric adenocarcinoma with NAIC (NCT05515796). Correlation between clinicopathologic characteristics and neoadjuvant efficacy was investigated. Bulk RNA sequencing data from 104 samples (from 75 patients in two independent cohorts) and single-cell RNA sequencing data from 105 treatment-naïve gastric adenocarcinomas were comprehensively analyzed to decipher the association of epithelial and microenvironmental characteristics and clinical responses.

Results:

The prespecified primary endpoints were achieved: pathologic complete regression rate was 30%, major pathologic regression rate was 43%, and the regimen was well tolerated. Analysis of baseline clinical–pathologic parameters revealed the intestinal subtype of Lauren’s classification as a key feature stratifying patients with increased sensitivity to NAIC. Mechanistically, an increased pool of DNA damage repair–active cancer cells and enrichment of CLEC9A+ dendritic cells in the tumor microenvironment were associated with enhanced responsiveness of the intestinal subtype gastric adenocarcinoma to NAIC. More importantly, an intestinal subtype–specific signature model was constructed by the machine learning algorithm NaiveBayes via integrating the transcriptomic features of both DNA damage repair–active cancer cells and CLEC9A+ dendritic cells, which accurately predicted the efficacy of NAIC in multiple independent gastric adenocarcinoma cohorts.

Conclusions:

Intestinal subtype is a histologic biomarker of enhanced sensitivity of gastric adenocarcinoma to NAIC. The intestinal subtype–specific signature model is applicable to guide NAIC for patients with locally advanced gastric adenocarcinoma.
Supplementary Method from SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Authors: Dave Foram , Vaghela Poonam , Heath Bryony , Dunster Zuzana , Dubinina Elena , Thakker Dhruma , Mann Katie , Chadwick Joe , Cane Gaëlle , Kaira Bubacarr G. , Mohammed Omar J. , Choudhury Ruhul , Paston Samantha , Parsons Tina , Vankemmelbeke Mireille , Durrant Lindy
Published: November 2024

Protein sequence and generation of SC134-TCB
Supplementary Table 2 from Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
Authors: Wang Weini , Zhou Yanchi , Wang Ji , Zhang Shu , Ozes Ali , Gao Hongyu , Fang Fang , Wang Yue , Chu Xiaona , Liu Yunlong , Wan Jun , Mitra Anirban K. , O’Hagan Heather M. , Nephew Kenneth P.
Published: November 2024

Pathways
Supplemental Figure 3 from SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Authors: Dave Foram , Vaghela Poonam , Heath Bryony , Dunster Zuzana , Dubinina Elena , Thakker Dhruma , Mann Katie , Chadwick Joe , Cane Gaëlle , Kaira Bubacarr G. , Mohammed Omar J. , Choudhury Ruhul , Paston Samantha , Parsons Tina , Vankemmelbeke Mireille , Durrant Lindy
Published: November 2024

Target-dependent killing
Supplemental Figure 11 from SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Authors: Dave Foram , Vaghela Poonam , Heath Bryony , Dunster Zuzana , Dubinina Elena , Thakker Dhruma , Mann Katie , Chadwick Joe , Cane Gaëlle , Kaira Bubacarr G. , Mohammed Omar J. , Choudhury Ruhul , Paston Samantha , Parsons Tina , Vankemmelbeke Mireille , Durrant Lindy
Published: November 2024

Individual tumour growth curves, dosing regimen study
Supplemental Figure 1 from SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Authors: Dave Foram , Vaghela Poonam , Heath Bryony , Dunster Zuzana , Dubinina Elena , Thakker Dhruma , Mann Katie , Chadwick Joe , Cane Gaëlle , Kaira Bubacarr G. , Mohammed Omar J. , Choudhury Ruhul , Paston Samantha , Parsons Tina , Vankemmelbeke Mireille , Durrant Lindy
Published: November 2024

Glycolipid binding validation and IHC
Supplementary Table 5 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

Comparison of published toxicokinetic parameters of approved vedotin ADCs with T-mavg-MMAU DAR4.
Supplementary Figure 10 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

Lysosomal degradation of T-mavg-MMAU DAR8 at pH 4.5.
Supplemental Table 1 from Plasma Concentrations of Multiple Oxysterols and Risk of Colorectal Adenomas
Authors: Passarelli Michael N. , McDonald Jeffrey G. , Thompson Bonne M. , Pomares-Millan Hugo , Palys Thomas J. , Rees Judy R. , Barry Elizabeth L.
Published: November 2024

Supplemental Table 1. Baseline characteristics of participants according to highest quartile of oxysterols.
Figure S7 from A Single-Cell Analysis of the NK-Cell Landscape Reveals That Dietary Restriction Boosts NK-Cell Antitumor Immunity via Eomesodermin
Authors: He Junming , Chen Donglin , Xiong Wei , Wang Yuande , Chen Shasha , Yang Meixiang , Dong Zhongjun
Published: November 2024

DR-fed mice promote the accumulation of DP NK cells by enhancing the expression of Eomes and its downstream target CXCR3.
Figure S9 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S9. H&E (hematoxylin and eosin) staining images for the entire dataset.
Figure S5 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S5. Random forest feature importance results with increased spatial network trimming threshold. Main text Figure 7 repeated if edges in spatial networks are trimmed with a higher threshold of 100 pixels (∼48.8 μm).
Figure S9 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S9. Up-regulation of PD-L1 and CD47 expression on tumor cells after oADV-W6-CaP infection.
Data from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Abstract
Surgical resection is a primary treatment option for patients with triple-negative breast cancer (TNBC), but it is associated with a high rate of postoperative local and metastatic relapse. Although chimeric antigen receptor–engineered NK (CAR-NK) cell therapy can specifically recognize and eradicate tumor cells, its therapeutic potency toward TNBCs is markedly suppressed by the hostile tumor microenvironment, which restricts the infiltration, survival, and effector functions of CAR-NK cells inside tumor masses. In this study, HER1-overexpressing TNBC-targeted CAR-NK (HER1-CAR-NK) cells were genetically engineered with catalase to endow them with tolerance toward the high levels of oxidative stress and hypoxia inside TNBC tumors through the catalytic decomposition of hydrogen peroxide, which is a principle reactive oxygen species inside tumors, into O2. We refer to these cells as HER1-CAR-CAT-NK cells. Upon intratumoral fixation with an injectable alginate hydrogel, HER1-CAR-CAT-NK cells enabled sustained tumor hypoxia attenuation and exhibited markedly enhanced persistence and effector functions inside TNBC tumors. As a result, locoregional HER1-CAR-CAT-NK cell therapy not only inhibited the growth of local primary residual tumors but also elicited systemic antitumor activity to suppress the growth of distant tumors. This study highlights that genetic engineering of HER1-CAR-NK cells with catalase is a promising strategy to suppress the postoperative local and distant relapse of TNBC tumors.
Data from Increased Red Cell Superoxide Dismutase Activity Is Associated with Cancer Risk: A Hidaka Cohort Study
Authors: Tanaka Shin-ichiro , Fujioka Yoshio , Tsujino Takeshi , Ishida Tatsuro , Hirata Ken-ichi
Published: November 2024

Abstract
Superoxide dismutase (SOD) catalyzes the highly reactive superoxide anion to form hydrogen peroxide, which facilitates cell proliferation and death. We investigated whether red cell SOD (R-SOD) activity is associated with an increased risk of cancer in a Japanese general population. We prospectively analyzed data from 1,921 participants (800 men and 1,121 women; age, 58.7 ± 14.7 years) in a Hidaka cohort study. After a median follow-up period of 10.9 years, 160 participants had developed cancer. The Cox proportional hazards model was used to estimate quartile-specific HRs and 95% confidential intervals (CI) for cancer risk. After adjustment for potential cancer risk factors including age, sex, current smoking habit, alcohol use, physical activities, body mass index, plasma immunoreactive insulin, and non–high-density lipoprotein cholesterol levels, we found a significant association between R-SOD activity and an increased risk of cancer (HR, 1.61; 95% CI, 1.03–2.52; P = 0.037). In analyses conducted separately by sex, a significant association was found in men (HR, 2.49; 95% CI, 1.35–4.59; P = 0.003) but not women (HR, 1.46; 95% CI, 0.70–3.05; P = 0.320). After excluding participants who developed cancer within 5 years of the baseline survey, the association was more evident in men (HR, 4.64; 95% CI, 1.88–11.45; P = 0.001). We found no association with cancer risk in women (HR, 1.01; 95% CI, 0.39–2.65; P = 0.983). Increased R-SOD activities were associated with an increased risk of cancer, particularly in men in this population.
Significance:
Our study is the first to show that increased R-SOD activity is associated with a significantly higher cancer risk in men but not in women. Antioxidative enzymes such as SOD are essential for maintaining cellular redox balance. Their roles in cancer development and prevention are yet to be fully elucidated.
Bicho Mau: notas sobre matanças de serpentes no norte e noroeste de Minas Gerais
Authors: Pereira Luzimar Paulo
Published: November 2024

La matanza de serpientes es una práctica generalizada en los límites de las regiones norte y noroeste de Minas Gerais. Una de las razones que justifican el sacrificio se refiere a la asociación que se establece entre el animal y el mal. En este artículo pretendo comprender el significado del mal, describir formas de matar serpientes y discutir posibles formas pacíficas de convivencia entre personas y animales.
O Bixiga em disputa: ambiente, cultura, memória e interesses imobiliários
Authors: Almeida Eneida de , Nascimento Flávia Brito do
Published: November 2024

Bixiga is currently experiencing a critical situation that threatens the preservation of what constitutes its most unmistakable cultural and environmental heritage, associated with the strong impact caused by the advance of real estate interests, announced by new buildings recently approved by Conpresp in its territory. Particular concern is the vulnerability to which the area known as Grota do Bixiga is being exposed, despite the existence of protective legislation agreed since the early 2000s. Concern is intensified by the fact that these developments create reckless precedents for others to be approved in the near future, thus putting an end to the possibility of preserving what remains of Grota do Bixiga. This approach allows us to look at a whole process of study, inventorying and consolidation of knowledge produced within the Historical Heritage Department, which began in the 1980s, linking architectural assets to the structuring elements of the urban fabric and to the social relationships that not only populate the memory of the place, but are kept alive in the cultural practices of the present. It also allows us to deal with the impasses between cultural heritage preservation policies and urban policies of a broader nature. It also allows us to deal with the impasses between cultural heritage preservation policies and broader urban policies. Finally, it allows us to analyze another layer of latent memory, unveiled by the discoveries linked to the excavations carried out for the construction of the Orange Line Subway Station. The recent archaeological finds have sparked an important debate about the origin of occupation of the neighborhood associated with the presence of the Quilombo Saracura, strengthening the memory of the black population, due to its representativeness and its persistence over time, as an essential element of the culture of the place, which cannot be erased or made invisible.
A norma de preservação de Ouro Preto como estratégia de preservação da paisagem histórica
Authors: Giannecchini Ana Clara , Guia George Alex da
Published: November 2024

O artigo descreve como uma abordagem inovadora de leitura da paisagem fundamentou a Portaria Iphan n.º 312/2010 da norma de preservação de Ouro Preto, considerando o espírito do lugar e as transformações urbanas e paisagísticas. A leitura realizada revelou fragilidades institucionais, riscos à preservação e preocupações com desastres naturais. Parte do pressuposto que a norma de preservação do Iphan é instrumento fundamental de gestão da paisagem, evidenciando suas relações com os instrumentos e  práticas de planejamento e gestão urbanos do município e a importância da cooperação intergovernamental. À luz de debates institucionais ocorridos em 2016 sobre a percepção do desempenho da Portaria n.o 312, o artigo encerra com apontamentos críticos sobre seus avanços e desafios.
O todo nas partes
Authors: Nassar Paulo , Farias Luiz Alberto de
Published: November 2024

Editorial da edição.
Detection of Right and Left Ventricular Dysfunction in Pediatric Patients Using Artificial Intelligence–Enabled ECGs
Authors: Anjewierden Scott , O'Sullivan Donnchadh , Mangold Kathryn E. , Greason Grace , Attia Itzhak Zachi , Lopez‐Jimenez Francisco , Friedman Paul A. , Asirvatham Samuel J. , Anderson Jason , Eidem Benjamin W. , Johnson Jonathan N. , Havangi Prakash Shisheer , Niaz Talha , Madhavan Malini
Published: November 2024

Background

Early detection of left and right ventricular systolic dysfunction (LVSD and RVSD respectively) in children can lead to intervention to reduce morbidity and death. Existing artificial intelligence algorithms can identify LVSD and RVSD in adults using a 12‐lead ECG; however, its efficacy in children is uncertain. We aimed to develop novel artificial intelligence–enabled ECG algorithms for LVSD and RVSD detection in pediatric patients.

Methods and Results

We identified 10 142 unique pediatric patients (age≤18) with a 10‐second, 12‐lead surface ECG within 14 days of a transthoracic echocardiogram, performed between 2002 and 2022. LVSD was defined quantitatively by left ventricular ejection fraction (LVEF). RVSD was defined semiquantitatively. Novel pediatric models for LVEF ≤35% and LVEF <50% achieved excellent test areas under the curve of 0.93 (95% CI, 0.89–0.98) and 0.88 (95% CI, 0.83–0.94) respectively. The model to detect LVEF <50% had a sensitivity of 0.85, specificity of 0.80, positive predictive value of 0.095, and negative predictive value of 0.995. In comparison, the previously validated adult data‐derived model for LVEF <35% achieved an area under the curve of 0.87 (95% CI, 0.84–0.90) for LVEF ≤35% in children. A novel pediatric model for any RVSD detection reached a test area under the curve of 0.90 (0.87–0.94).

Conclusions

An artificial intelligence–enabled ECG demonstrates accurate detection of both LVSD and RVSD in pediatric patients. While adult‐trained models offer good performance, improvements are seen when training pediatric‐specific models.
Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular–Vascular Coupling and Wasted Pressure Effort
Authors: Marôco João L. , Lane Abbi D. , Ranadive Sushant M. , Yan Huimin , Baynard Tracy , Fernhall Bo
Published: November 2024

Background

Black compared with White adults have a higher risk for left‐ventricular hypertrophy and heart failure possibly due to the early onset of alterations in ventricular–vascular coupling (ie, arterial [
E
a
] to ventricular elastance [
E
es
] ratio) and wasted pressure effort (
E
w
). Aerobic training preserves the coupling ratio (
E
a
/
E
es
) and attenuates
E
w
, but whether this applies to Black adults is unknown. We hypothesized that Black rather than White adults would have greater training‐induced improvements in the
E
a
/
E
es
and
E
w
.

Methods and Results

Fifty‐four young adults with normal blood pressure (Black=24 [58% female]; White=30 [47% female], mean=24 years; SD=5 years) completed an 8‐week aerobic training (3 times/week, 65%–85% peak oxygen uptake).
E
a
/
E
es
was estimated via echocardiography and scaled to body surface area, and the
E
w
was estimated from pulse contour analysis. Black adults had lower
E
a
/
E
es
(difference (
d
)=0.49 [95% CI, 0.14–0.84 mm Hg/mL],
P
=0.007) and higher
E
w
(
d
=1127 [95% CI, 104–2007 dyne cm
−2
 s],
P
=0.005). Both groups exhibited similar (race‐by‐training interaction,
P
=0.986) training‐induced reductions in scaled
E
a
(
d
=−0.11 [95% CI, −0.18 to −0.04 mm Hg/mL],
P
<0.001). Only in White adults, scaled
E
es
increased (
d
white
=0.39 [95% CI, 0.11–0.32 mm Hg/mL],
P
=0.003) and
E
a
/
E
es
was reduced (
d
white
=−0.16 [95% CI, −0.33 to −0.18 mm Hg/mL/m
2
],
P
<0.001). Conversely, only Black adults exhibited reductions in
E
w
after training (
d
black
=−699 [95% CI, −1209 to −189 dyne cm
−2
 s],
P
=0.008).

Conclusions

Aerobic training‐induced differential effects on
E
a
/
E
es
and
E
w
of White and Black young adults hold the potential to reduce racial disparities. This warrants confirmation in a larger sample.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01024634.