bluuebunny/crossref_metadata_2025 huggingface dataset:
SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the
Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients
Authors: Dong Yuxuan , Jin Fengbo , Wang Jing , Li Qingsheng , Huang Zhenqi , Xia Leiming , Yang Mingzhen
Published: July 2023

Background:

DNA hypermethylation plays a critical role in the occurrence and progression
of acute myeloid leukemia (AML). The mitochondrial serine transporter, SFXN3, is vital for onecarbon
metabolism and DNA methylation. However, the impact of SFXN3 on the occurrence and progression
of AML has not been reported yet.

Objective:

In this study, we hypothesized that SFXN3 indicates a poor prognosis and suggested tailored
treatment for AML patients.

Methods:

We used GEPIA and TCGA repository data to analyze the expression of SFXN3 and its correlation
with survival in AML patients. RT-qPCR was used to detect the SFXN3 level in our enrolled
AML patients and volunteers. Additionally, Whole Genome Bisulfite Sequencing (WGBS) was used
to detect the genomic methylation level in individuals.

Results:

Through the TCGA and GEPIA databases, we found that SFXN3 was enriched in AML patients,
predicting shorter survival. Furthermore, we confirmed that SFXN3 was primarily overexpressed
in AML patients, especially non-M3 patients, and that high SFXN3 in non-M3 AML patients
was found to be associated with poor outcomes and frequent blast cells. Interestingly, non-M3
AML patients with high SFXN3 levels who received hypomethylating therapy showed a higher CR
ratio. Finally, we found that SFXN3 could promote DNA methylation at transcription start sites (TSS)
in non-M3 AML patients. These sites were found to be clustered in multiple vital cell functions and
frequently accompanied by mutations in DNMT3A and NPM1.

Conclusion:

In conclusion, SXFN3 plays an important role in the progression and hypermethylation
in non-M3 AML patients and could be a potential biomarker for indicating a high CR rate for hypomethylating
therapy.
THE INFLUENCE OF THE PLANT ADAPTOGENE "VICTORIN" ON THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM IN PERSONS WITH INCREASED THERMAL SENSITIVITY.
Authors: Гук Вікторія , Вадзюк Степан
Published: July 2023

Abstract. Introduction. Global warming is the most urgent environmental problem today. It has been established that the optimal functioning of the cardiovascular system is necessary for the survival of the human body in the conditions of climate change. Such means as adaptogens are used to increase the body's resistance to adverse environmental factors.

The aim of the study. To study the influence of the plant adaptogen "Victorin" on the functional state of the cardiovascular system of healthy individuals with increased sensitivity to heat.

Research materials and methods. 14 healthy students aged 17-20 years with increased sensitivity to temperature were selected. All persons were suggested to use 1 capsule of the herbal preparation "Victorin" daily in the first half of the day for 30 days. Assessment of subjective changes in the general state, well-being and functional state of the cardiovascular system using the Robinson index, the index of the response of the cardiovascular system to psycho-emotional stress, the Kerdo index, determination of adaptation potential according to the method of R.M. Baevsky was conducted on the 1st, 15th and 30th days of the study.

Research results. All those examined on the 30th day of the study noted that they feel better heat tolerance, feel more comfortable in conditions of increased ambient temperature. The established tendency to decrease the average value of the Robinson index by 10 n.u. (10.1%), compared to the 1st day of the study. The average value of the index of the response of the cardiovascular system to psycho-emotional stress on the 30th day decreased by 0.147 n.u. (11%) (p<0.01). After a 30-day intake of the plant adaptogen "Victorin", a decrease in the tone of the sympathetic nervous system and its shift towards autonomous balance was revealed. The value of adaptation potential on the 30th day of the study is 9.3% less, compared to the initial indicators (р<0.01).

Conclusions. Taking a plant adaptogen in people with a higher sensitivity to heat caused a tendency to increase the reserve capacity of the cardiovascular system and its more economical activity, contributed to an increase in stress resistance, a decrease in the tone of the sympathetic nervous system, and an increase in the adaptation potential.
Фактори ризику розвитку рецидиву або продовження хвороби у хворих на колоректальний рак
Authors: Maliborska S.V. , Holotiuk V.V.
Published: July 2023

Колоректальний рак (КРР) в Україні впевнено посідає 4-5 місце в структурі загальної онкологічної захворюваності впродовж багатьох років. Незважаючи на постійний прогрес та вдосконалення методів діагностики та лікування хворих на КРР, безрецидивна виживаність залишається низькою. Нами було проаналізовано результати обстеження та лікування 188 хворих на КРР ІІ-IІІ стадій (Т2-3N0-2М0), у яких виник рецидив або продовження хвороби в КНП «Прикарпатський клінічний онкологічний центр Івано-Франківської обласної ради» в період 2012-2020 роки. Аналізували такі прогностичні фактори: стадія, стать, вік пацієнта, локалізація пухлини, кількість уражених лімфовузлів, інвазію пухлини до серозної оболонки, некроз пухлини та наявність периопераційного хіміопроменевого лікування. Під час визначення прогностичних факторів було встановлено достовірний прямий непараметричний зв'язок між наявністю післяопераційних ускладнень та безрецидивною виживаністю хворих, а також отриманням цими хворими курсів ад'ювантної хіміотерапії (p <0,01). При аналізі локалізації пухлини не виявлено достовірного зв'язку з безрецидивною виживаністю хворих (p> 0,05). Встановлено, що кількість уражених лімфатичних вузлів не впливає на безрецидивну та загальну виживаність хворих (p = 0,35075; p = 0,08584), але факт ураження лімфатичних вузлів має прямий вплив на безрецидивну та загальну виживаність хворих (p = 0,01869; p = 0,00919). Встановлено прямий кореляційний зв'язок у хворих з раком прямої кишки між дозою телегамматерапії та протяжністю пухлини (r = 0,37; p <0,05). Для індивідуалізації та покращення ефективності лікування хворих на КРР слід продовжувати пошуки факторів ризику, що можуть сприяти рецидиву захворюваня та зменшувати тривалість життя пацієнта.
Professionalism and the challenges of inclusion: An evaluation of special education teachers' practice
Authors: Algraigray Hatim Hamdi
Published: July 2023

This research paper critically examines the role of professionalism in shaping the practice of special education (SE) teachers. Working with students with diverse needs, SE teachers face complexities and contradictions in their profession. Despite the initiation of inclusive education in 1994 as a promising concept to support students with disabilities, its effective implementation remains elusive. Therefore, this study delves into the educational system and regulatory frameworks that govern teacher work to identify areas of improvement. Qualitative methods were employed to explore the impact of accountability activities, particularly standards-based tests, on SE teachers' professionalism. The findings reveal a negative influence of such activities on their professional autonomy and well-being. The prevailing nature of educational systems that restrict teachers' authority and collaborative opportunities appears to contribute to stress and ethical dilemmas. Interestingly, the study contradicts prior research by indicating that SE teachers' professionalism is not necessarily linked to the successful implementation of inclusion. The research underscores the significance of autonomy and flexibility for SE teachers, allowing them to tailor their approaches to meet the needs of students with disabilities effectively. This autonomy contributes significantly to the successful integration of inclusion practices. Moreover, the study emphasizes the crucial role of autonomous education systems in fostering teacher practices in inclusive classrooms and facilitating the development of knowledge and skills among students with disabilities. Overall, this research enhances our understanding of how empowering education systems can foster a conducive environment for SE teachers, consequently benefiting students with disabilities in inclusive settings.
HAS SECONDARY MORTGAGE MARKET PROMOTE HOUSE AFFORDABILITY? EVIDENCE FROM INDONESIA
Authors: Dipta Praditya Mega
Published: July 2023

The advantage of secondary mortgage market establishment to decrease housing cost, theoretically, had been mentioned frequently in domestic and international research. However, research on this matter in Indonesia is still limited to narrative descriptive. This research engages sequential explanatory design by utilizing empirical evidence from financial perspective to analyse the impact of securitization to the yield spread premium from monthly data ranging from June 2017-April 2021. In quantitative phase, this research found that either securitization volume or the launch of new series of asset backed securities (ABS) significantly affects mortgage rate, contrary to aggregate mortgage volume, prepayment risk, and yield curve risk. In the qualitative phase, it is explored that the reason of securitization’s stagnation is market unreadiness.
MALAYSIAN PROPERTY MARKET, THE STOCK MARKET AND MACROECONOMIC VARIABLES
Authors: Mohd Idris Tajul Ariffin
Published: July 2023

This study examined the interactions and linkages between the property market, stock market, and macroeconomic variables. The stock market, in the long run, has a significant impact on property. Changes in house prices and stock markets have wealth and credit-price effects spilled over to economic growth. Both property and equity markets have a close dependency on income, inflation and monetary policy. The inference and dynamic relationship within asset markets have the capacity to explain the boom and bust cycles. The great potential lies with property and stock market interaction mechanisms to reflect economic conditions and as a source to enrich the present macroeconomic indicators. The Malaysian equity market was observed to be significantly co-integrated with the disaggregated real estate market (state level). The real estate market was mainly found to have a positive relationship with the stock market, GDP per capita (income) and consumer price index (CPI). However, real estate always had a negative relationship with interest rates. While real estate had a positive relationship with real GDP per capita in the long run, the relationship was not significant. This insignificance relationship covers all states and property types. The income coefficients were low and most of non-causality in the short run. This suggests a need for cautious from house price overheating. Price upsurge beyond the reach of the public may get caught with a sudden decline of the people’s affordability level. The impact of property price increase was higher than CPI (inflation). The inflation positive response on property is unusual as it normally follows the interest rate being negative. The shortage of affordable houses has pushed up prices. Inflation coefficients were mainly significant and much higher compared to stock and income coefficients. In short term dynamic linkages, bidirectional causality was detected between lending rates and the overall property market. This suggests a high temporal impact of monetary policy on the property market at the national level.
FACTORS INFLUENCING HOUSE BUYER’S DECISION IN MALAYSIA. CASE STUDY: SEPANG, SELANGOR
Authors: Zulkifli Fatimah , Ismail Hafiszah
Published: July 2023

Housing is a basic human need as explained in the Maslow hierarchy needs. Having a house is a very important entity in ensuring a sense of security for each individual and family. Deciding on buying a house is a crucial decision since housing expenses involved a large amount of cost in individual monthly expenses. Furthermore, the homeownership rate in Malaysia as reported by the Department of Statistics Malaysia (DOSM) in 2019 didn’t increase significantly. Thus, the government and house developers need to identify the important factors that influence the house buying decision-making to increase the homeownership rate in Malaysia.   This study investigates the factors influencing housing buying decisions and the difference in factors influencing different income groups in Sepang, Selangor. This study measures the internal factors and external factors influencing house-buying decisions. The internal factors measure the income, stage of life cycle, employment and education subfactors. The external factors measure the financial and economic condition, house price, location, neighbourhood, house type and design and also government housing incentives. A mixed method was applied in this study by interviewing real estate experts and also a survey of 184 respondents in the case study area. Using transcribe method and analysing of the survey data with descriptive and inferential analyses to study the influencing factors. The real estate expert and respondents agreed all the factors were influencing house buying decisions except for education. The importance of the factors is also different among the income groups. For internal factors, all income groups agree that income is the most influential factor followed by employment, stage of life cycle and education. The importance of external factors is different among the groups.
SUSTAINABLE AFFORDABLE STRUCTURAL MODEL IN HOME OWNERSHIP
Authors: Ismail Suhana , Abdul Manaf Azima , Hussain Mohd Yusof , Awang Zainudin , Muhamad Azian Fatin Umaira , Syarifuddin Noviatin
Published: July 2023

Home is a basic human need. Every year, the government is responsible for enacting a more sustainable and inclusive housing policy to ensure the adequate provision, quality and affordable housing to meet the needs of the growing sustainable communities. The aim of the current research is to analyse affordability as a mediator in the relationship between economic, social and environmental factors towards the need for home ownership among civil servants in Klang Valley. Path Analysis and Boostrapping through Structural Equation Modelling (SEM) are used to see the relationship and influence between sustainability and affordability variables. There is a significant relationship between all elements of affordability with economic, social and environmental factors. Mediation effect (mediator) for the element of affordability that is tested in the construct relationship between economic, social and environmental factors on the need for home ownership. Finally, this study succeeded in forming a sustainable affordable structural model in home ownership.
Political Decision-Making in the Context of the Migration Process in Russia at the Present Stage (Problems and Prospects)
Authors: Muhina Ya. A.
Published: July 2023

Relevance.The genesis and conjuncture of the development of the modern migration process on a global scale and at the level of individual states are accompanied by the dynamization and intensification of most political risks and threats in the actualized conditions of increasing international and interstate interdependence and interdependence. In turn, this requires the development and coordination of optimal mechanisms and tools for making political decisions on migration issues, taking into account national specifics. For Russian political realities, the most preferable option is to operate with the terminology of socio-political stability and security. Accordingly, it is necessary to transform the system of approaches to understanding the modern migration agenda adopted at the level of the Russian political leadership.Purpose.The main purpose of writing the article is to offer the author's methodological recommendations for making political decisions on migration problems.Objectives:determination of the features of the migration process in Russia at the present stage, formulation of the main problems and prospects for the development of the modern Russian migration process.Methodology.The author mainly used the following group of methods in the process of writing the article: secondary analysis of information data, content analysis, event analysis, sociological analysis, formal legal analysis, statistics.Results.Taking into account, firstly, the peculiarities of the migration process in Russia at the present stage, and secondly, the main problems and prospects for the development of the modern Russian migration process at the present stage, some author's methodological recommendations for political decision-making are proposed within the following key blocks: ideological and value design, normative activity, the work of specialized state authorities, the implementation of monitoring of political decision-making.Conclusion.At the present stage of Russia's political and socio-economic development, there is a rather serious and extensive block of unresolved issues and problems in the field of migration, requiring the appropriate joint active participation of various social groups and forces. It is assumed that within the framework of Russian national realities, when making political decisions, a practice-oriented approach based on full consideration of cultural characteristics and maximum provision of socio-political stability is most appropriate.
Mechanism of Realization of National Interests: Efficiency Factors
Authors: Belyaev V. P. , Belyaeva G. S.
Published: July 2023

Relevance. This article is based on the meanings that reveal the problem of increasing the effectiveness of the mechanism for regulating national interests. The main factors of this plan affecting the functionality of the mechanism are considered. In particular, the relevant conditions are investigated, criteria are named, among which the main attention is paid to achieving the goals of the mechanism under study, overcoming the obstacles that arise in this case, as well as some other ways (methods) of its optimization. Scientific judgments, results and conclusions are supported by an analysis of regulatory legal acts.Purpose. To investigate the factors influencing the effectiveness of the mechanism of realization of national interests: conditions, criteria, requirements and others.Objectives: to study, in particular, the conditions, criteria, goals of the mechanism for the realization of national interests, as well as to identify the circumstances that hinder its effectiveness.Methodology. The methodological basis of the research includes general scientific techniques and methods of scientific cognition, as well as special and private scientific methods - formal legal and interpretative.Results. Based on the analysis of scientific, regulatory and legal sources and legal practice, the factors (including requirements) of the effectiveness of the mechanism for the implementation of national interests have been established and systematized, including: economic and resource feasibility; balance of the legal framework; clarity, utmost simplicity and intelligibility of legal constructions and formulations, ensuring in practice their uniform interpretation and subsequent application by authorized entities; social validity and others.Conclusion. The factors of effectiveness of the legal security mechanism in the sphere of realization of national interests are: creation of necessary conditions, including control over its functioning, identification of shortcomings of legal consolidation, reasons for its inefficiency, updating of the regulatory framework in accordance with changing circumstances and existing public needs, elimination of emerging obstacles to the realization of national interests.
"Deeds for the Benefit of the Development of Cities": About the Association of Artists of the Irkutsk Province in the 1880-1900s
Authors: Tkachev V. V.
Published: July 2023

Relevance. In the 1880s - 1900s, artists sought to create creative associations, whose activities were aimed at the development of public initiative, urban spaces. The gradual discovery of new funds, sources in the archives, the identification of information about artists, the history of acquisition of museums, the creation of exhibitions, update the process of studying the association of artists for the benefit of the development of cities in the Irkutsk province.The purpose is to restore the history of the association of artists and deeds in the organization of work on the development of cities in the Irkutsk province in the 1880-1900s.Objectives: to study documentary evidence of artistic events in order to understand the principles of interaction between artists and the urban community on the construction of work on the improvement of spaces, the development of territories; consider the activities of artists in the framework of the creation of museum collections, creative associations for the organization of traveling exhibitions and expositions based on the research; determine the role of art communities in the creation of exhibition, mobile spaces, the formation of visitors' ideas about the role of museums in the development of cities in the Irkutsk province.Methodology. The work uses an integrated approach. The principle of historicism, objectivity, scientific character is taken into account, problem-chronological and historical-genetic methods are used.Results. In the process of parsing the archives of Irkutsk, materials were found that describe the artistic work of artists in the development of museums in the Irkutsk province. In the 1880s-1900s, it is possible to observe the process of urban residents turning to the preservation of artistic heritage, the improvement of cultural centers to attract the attention of the younger generation to the work of creative associations in the acquisition of regional museum collections.Conclusions. Artists of the Irkutsk province create associations to maintain exhibition, mobile spaces that existed at museums and generally significant city places. The attitude of urban residents to well-known artistic and educational centers is changing. The interest of artists in the development of cities confirms the effectiveness of interaction with the public. Materials about the work of creative associations represent events about the formation of art spaces.
Actual Problems of Domestic Legal Regulation of the Collection, Storage and Transmission of Genomic Information in the Context of Modern Challenges
Authors: Balashov K. G. , Kravchenko N. V.
Published: July 2023

Relevance. The implementation of the international project "Human Genome" made it possible to decipher it, however, the volume of this information and possibilities of its application both for universal (pandemic control) and terrorist purposes (development of biological weapons, targeted at a particular nation), especially in conditions of political tension and competition for leadership, determine the need to forecast potential risks and develop an adequate legal regulation.The purpose of this study is to assess the current state of security of genomic information obtained in the framework of biomedical research, as well as within the framework of implementation of public policy in the sphere of public security. It is also necessary to study the experience of foreign countries in this field with a view to its further use in Russian legal practice.Objectives. Comprehensive study of legal regulation of the collection, storage, use and destruction of genomic information allowed to identify gaps in legal regulation. Finding ways to solve them is the objective of this study.Methodology. To achieve the set objective were applied methods of scientific knowledge: analysis, synthesis, system-analytical, formal-logical, system-legal methods by means of which the authors carried out an analytical review of domestic and foreign legislation, identified the specifics of legal relations under study and proposed solutions to the identified legal problems.Results of the study are formulated suggestions for changes in legal acts of domestic legislation relating to the collection, storage and control of access to genomic information, taking into account the studied foreign experience. Conclusion. The existing regulations on genomic information do not provide protection from processing and transfer to third parties. For this reason human genomic data should be designated as "sui generis", and legal regulation should be expanded, including formation of federal agencies responsible for regulation of ethical and legal aspects of genetic and genomic research.
Ir Sensory Properties of Multilayer Nanocomposite CuO/CNPs Films Produced by Electroporetic Synthesis
Authors: Aung N. W. , Pugachevskii М. A. , Filippov V. V. , Yemelyanov V. M.
Published: July 2023

Purpose. Formation and studying the sensory properties of multilayer nanocomposite electrophoretic CuO/CNPs films in the infrared range.Methods. Study of the morphology and size composition of CuO/CNPs nanocomposite films using atomic force microscopy and scanning electron microscopy; determination of the chemical composition using X-ray diffractometry, the study of sensory sensitivity under infrared irradiation with a fiber-optic laser source with a wavelength of λ = 1064 nm; study of the temporal characteristics of the induced photoelectromotive force using optoelectric measurements (ADC L-CARD E2010D) interfaced with a personal computer.Results. Nanocomposite CuO/CNPs films 0.1 to 1 µm thick were obtained by electrophoretic synthesis on a glass substrate. It has been established that CuO/CNPs nanocomposite films are formed due to the ordered structuring of carbon nanoparticles along the direction of the electric field under the action of electrophoretic forces. At the same time, due to the electrolytic process, a layer of copper oxide from metal electrodes is formed on the surface of the carbon particles. The limiting size of carbon particles was 50-70 nm, depending on the parameters of film production. A technique has been developed for producing multilayer CuO/CNPs composite films with a thickness of one to ten layers. It has been established that when the synthesized ten-layer nanofilms are irradiated with infrared radiation with an intensity of 75 mW/cm-2, the value of the photogenerated EMF reaches 122.5 mV.Conclusion. Multilayer nanocomposite CuO/CNPs films with infrared sensor properties were obtained. It has been established that with an increase in the thickness of the synthesized films from one to ten layers, the photo-EMF under IR irradiation with an intensity of 75 mW/cm-2 increases from 17 to 122.5 mV.
Composition, Structure and Properties of Antifriction Alloys Based on the Charge Obtained by Electrodispersion of Bronze Waste BrO5C25 in Kerosene
Authors: Ageev E. V. , Pereverzev A. S. , Yemelyanov V. M. , Serebrovsky V. V.
Published: July 2023

Purpose. Study of the composition, structure and properties of antifriction alloys based on the electroerosion charge of bronze BrO5C25 obtained in a carbon–containing medium lighting kerosene.Methods. Dispersion of the waste of the BrO5S25 alloy was carried out at an installation for electrodispersing electrically conductive materials. The waste of the BrO5C25 alloy was used as metal waste. Lighting kerosene was used as the working fluid.As a result of exposure to short-term electrical discharges between the electrodes and the waste, their destruction occurred with the formation of fine particles. To obtain compacted materials, a Herzog TP 20 manual table press was used. Modern equipment and complementary methods of physical materials science were used to study the composition, structure and properties of the sintered products obtained.Results. Surface analysis showed that the alloys have a fine-grained structure, uniform phase distribution and a small number of pores. The analysis of the elemental composition found that carbon is contained on the surface of the new alloys, and all other elements Sn, Cu and Pb are distributed relatively evenly. The analysis of the studied alloys showed the presence of phases in them: Cu, CuSn, SnO, CuO, PbO, Pb. There are no carbide-forming elements in the alloy. It has been experimentally established that the composition, structure and properties of the charge dispersed by electroerosion of bronze BrO5C25 affect the tribological properties of the alloy blanks. In particular, the presence of free carbon in the alloy from the electroerosion charge obtained in kerosene, which acts as a solid lubricant, leads to a decrease in the coefficient of friction.Conclusion. It is shown that alloys obtained from an electroerosive charge have higher microhardness values in comparison with an alloy obtained from an industrially used charge. A significant increase in the microhardness of alloys is explained by the presence of highly hard particles formed during the quenching of metal vapors in the working fluid during dispersion. The presence of small fractions in electroerosive materials contributes to an increase in the density of compressions and a decrease in the porosity of workpieces.
Optimization of the Process of Obtaining a Charge of Lead-Antimony Alloy SSu3 by the Electroerosion Method in Distilled Water
Authors: Ageeva E. V. , Korolev M. S. , Pereverzev А. S. , Ageeva A. E.
Published: July 2023

The purpose of this work was to optimize the process of obtaining a charge of lead-antimony alloy SSu3 by the electroerosion method in distilled water according to the criterion of average particle size.Methods. At the experimental facility for the production of lead-antimony powders from conductive materials, the waste of the SSu3 alloy was dispersed in distilled water at a loading weight of 250 g. The following electrical parameters of the installation were used: voltage at the electrodes from 100–200 V; capacitance of capacitors 25–65 UF; pulse repetition frequency 25–50 Hz. The average particle size was studied using the Analysette 22 NanoTec plus laser particle size analyzer. The determination of the optimal parameters of the EED installation was carried out by setting up a complete factorial experiment (PFE) on the average particle size of the obtained electroerosive materials. The parameters of the EED installation operation were selected as factors: the voltage at the electrodes, the capacitance of the discharge capacitors and the pulse repetition rate.Results. According to the conducted series of experiments, the results of which are presented in the table, the limiting values of the optimization parameter y (the average size of electroerosive particles) were determined, which amounted to: 44 microns with a capacity of 65.5 UF discharge capacitors, a voltage at the electrodes of 200 V, a pulse repetition frequency of 75 Hz.The conducted studies have shown that by the method of electroerosive dispersion of SSu3 alloy waste in distilled water, it is possible to obtain an alloy powder with a uniform distribution of alloying elements.Conclusion. Optimization of the process of obtaining the charge of lead-antimony alloy SSu3 by the electroerosion method in distilled water according to the criterion of the average particle size was carried out. The results obtained can be used by enterprises of the industrial sector for the production of lead-antimony powder.
Detection of Anomalies in Additively Manufactured Metal Parts Using CNN and LSTM Networks
Authors: Modir Alireza , Casterman Arnaud , Tansel Ibrahim
Published: July 2023

The process of metal additive manufacturing (AM) involves creating strong, complex components by using fine metal powders. Extensive use of AM methods is expected in near future for the production of small and medium-sized batches of end-use products and tools. The ability to detect loads and defects would enable AM components to be used in critical applications and improve their value. In this study, the Surface Response to Excitation (SuRE) method was used to investigate wave propagation characteristics and load detection on AM metallic specimens. With completely solid infills and the same geometry, three stainless steel test bars are produced: one conventionally and two additively. To investigate the effect of infills, four bars with the same geometries are 3D printed with triangular and gyroid infills with either 0.5 mm or 1 mm skin thickness. Two piezoelectric disks are attached to each end of the test specimens to excite the parts with guided waves from one end and monitor the dynamic response to excitation at the other end. The response to excitation was recorded when bars were in a relaxed condition and when compressive loads were applied at five levels in the middle of them. For converting time-domain signals into 2D time-frequency images, the Short-Time Fourier Transform (STFT) and Continuous Wavelet Transform (CWT) were implemented. To distinguish the data based on fabrication characteristics and level of loading, two deep learning models (Long Short-term Memory algorithm (LSTM) and Convolutional Neural Networks (2D CNN)) were utilized. Time-frequency images were used to train 2D CNN, while raw signal data was used to train LSTM. It was found that both LSTM and 2D CNN could estimate solid parts' loading level with an accuracy of more than 90%. In parts with infills, CNN outperformed LSTM for the classification of over five classes (internal geometry and loading level simultaneously).
Effectiveness of Home-Based Telerehabilitation Interventions for Dysphagia in Patients With Head and Neck Cancer: Systematic Review
Authors: Yang Wenwen , Du Yifei , Chen Mengran , Li Sufang , Zhang Fan , Yu Peiyang , Xu Xiaoxia
Published: July 2023

Background

Multimodal treatment–induced dysphagia has serious negative effects on survivors of head and neck cancer. Owing to advances in communication technologies, several studies have applied telecommunication-based interventions that incorporate swallowing exercises, education, monitoring, feedback, self-management, and communication. It is especially urgent to implement home-based remote rehabilitation in the context of the COVID-19 pandemic. However, the optimal strategy and effectiveness of remote interventions are unclear.

Objective

This systematic review aimed to examine the evidence regarding the efficacy of telerehabilitation for reducing physiological and functional impairments related to swallowing and for improving adherence and related influencing factors among head and neck cancer survivors.

Methods

The PubMed, MEDLINE, CINAHL, Embase, and Cochrane Library databases were systematically searched up to July 2023 to identify relevant articles. In total, 2 investigators independently extracted the data and assessed the methodological quality of the included studies using the quality assessment tool of the Joanna Briggs Institute.

Results

A total of 1465 articles were initially identified; ultimately, 13 (0.89%) were included in the systematic review. The quality assessment indicated that the included studies were of moderate to good quality. The results showed that home-based telerehabilitation improved the safety of swallowing and oral feeding, nutritional status, and swallowing-related quality of life; reduced negative emotions; improved swallowing rehabilitation adherence; was rated by participants as highly satisfactory and supportive; and was cost-effective. In addition, this review investigated factors that influenced the efficacy of telerehabilitation, which included striking a balance among swallowing training strategy, intensity, frequency, duration, and individual motor ability; treating side effects of radiotherapy; providing access to medical, motivational, and educational information; providing feedback on training; providing communication and support from speech pathologists, families, and other survivors; and addressing technical problems.

Conclusions

Home-based telerehabilitation has shown great potential in reducing the safety risks of swallowing and oral feeding, improving quality of life and adherence, and meeting information needs for dysphagia among survivors of head and neck cancer. However, this review highlights limitations in the current literature, and the current research is in its infancy. In addition, owing to the diversity of patient sociodemographic, medical, physiological and functional swallowing, and behavioral factors, we recommend the development of tailored telemedicine interventions to achieve the best rehabilitation effects with the fewest and most precise interventions.
The Association Between Solid Fuel Use and Visual Impairment Among Middle-Aged and Older Chinese Adults: Nationwide Population-Based Cohort Study (Preprint)
Authors: Jiang Qingqing , Wang Shiqi , Zhang Hao , Guo Yan , Lou Yiling , Huang Shen , You Qiqi , Cao Shiyi
Published: July 2023

BACKGROUND

Indoor air pollution has been reported to have adverse effects on the eye; however, the health effects of exposure to cooking with solid fuels on visual impairment remain unclear in China.

OBJECTIVE

We aimed to examine the association between cooking with solid fuels and visual impairment, including distance visual impairment (DVI) and near visual impairment (NVI).

METHODS

Data were obtained from the China Health and Retirement Longitudinal Study, a nationwide survey of adults aged over 45 years who were enrolled in 2011 (Wave 1) and followed up in Wave 2 (2013), Wave 3 (2015), and Wave 4 (2018). We used Cox proportional hazards models to determine the association between solid fuels use and visual impairment. Additionally, the impact of switching cooking fuel types on vision function were examined through wave-specific data analysis (Wave 1 and Wave 4). Interaction and subgroup analyses were performed to explore the potential effect modifiers. Data were collected using the stratified multistage random sampling method and further analyzed using SPSS 27.0 and R 4.2.1 statistical software packages.

RESULTS

A total of 9559 middle-aged and older Chinese adults without visual impairment at baseline were included in the study, with 51.2% (n=4914) of the participants reporting that they cooked with solid fuels. During the follow-up period, 2644 (27.5%) and 3130 (32.6%) participants developed DVI and NVI, respectively. Compared with the clean fuel users, participants who cooked with solid fuels had a higher risk of DVI (hazards ratio [HR] 1.38, 95% CI 1.28-1.50) and NVI (HR 1.18, 95% CI 1.10-1.27). In addition, switching the cooking fuel type from clean to solid fuels was associated with an elevated risk of DVI (HR 1.51, 95% CI 1.15-1.98) and NVI (HR 1.39, 95% CI 1.06-1.82) compared to persistently using clean fuels during the follow-up period, although no protective effect of switching from solid to clean fuels on NVI was found (P=.52). In subgroup analysis, we found that cooking with solid fuels increased the risk of DVI in participants younger than 65 years (HR 1.41, 95% CI 1.28-1.55), men (HR 1.45, 95% CI 1.28-1.65), urban residents (HR 1.41, 95% CI 1.08-1.75), and smokers (HR 1.43, 95% CI 1.25-1.64). By contrast, negative effects of cooking with solid fuels on NVI were found in nonsmokers (HR 1.21, 95% CI 1.11-1.33) and urban residents (HR 1.20, 95% CI 1.10-1.37).

CONCLUSIONS

Cooking with solid fuels was associated with an increased risk of visual impairment among middle-aged and older Chinese adults. These findings indicate that promoting the utilization of clean fuels is conducive to reducing the burden of visual impairment for the public.
Daily Activity Lifelogs of People With Heart Failure: Observational Study (Preprint)
Authors: Tegegne Teketo Kassaw , Tran Ly-Duyen , Nourse Rebecca , Gurrin Cathal , Maddison Ralph
Published: July 2023

BACKGROUND

Globally, heart failure (HF) affects more than 64 million people, and attempts to reduce its social and economic burden are a public health priority. Interventions to support people with HF to self-manage have been shown to reduce hospitalizations, improve quality of life, and reduce mortality rates. Understanding how people self-manage is imperative to improve future interventions; however, most approaches to date, have used self-report methods to achieve this. Wearable cameras provide a unique tool to understand the lived experiences of people with HF and the daily activities they undertake, which could lead to more effective interventions. However, their potential for understanding chronic conditions such as HF is unclear.

OBJECTIVE

This study aimed to determine the potential utility of wearable cameras to better understand the activities of daily living in people living with HF.

METHODS

The “Seeing is Believing (SIB)” study involved 30 patients with HF who wore wearable cameras for a maximum of 30 days. We used the E-Myscéal web-based lifelog retrieval system to process and analyze the wearable camera image data set. Search terms for 7 daily activities (physical activity, gardening, shopping, screen time, drinking, eating, and medication intake) were developed and used for image retrieval. Sensitivity analysis was conducted to compare the number of images retrieved using different search terms. Temporal patterns in daily activities were examined, and differences before and after hospitalization were assessed.

RESULTS

E-Myscéal exhibited sensitivity to specific search terms, leading to significant variations in the number of images retrieved for each activity. The highest number of images returned were related to eating and drinking, with fewer images for physical activity, screen time, and taking medication. The majority of captured activities occurred before midday. Notably, temporal differences in daily activity patterns were observed for participants hospitalized during this study. The number of medication images increased after hospital discharge, while screen time images decreased.

CONCLUSIONS

Wearable cameras offer valuable insights into daily activities and self-management in people living with HF. E-Myscéal efficiently retrieves relevant images, but search term sensitivity underscores the need for careful selection.
Aktivitas Kehidupan Malam di Kawasan Jalan Malioboro (Studi Terhadap Pemuda Pengunjung Malioboro Saat Pandemi COVID–19)
Authors: Sukarno Isfan Fajar , Vernanda Rani Noor
Published: July 2023

The COVID-19 pandemic that occurred in Indonesia caused the closure of public spaces as an effort to limit social interaction to prevent transmission. This policy affects the needs of youth for public spaces as a means for them to carry out night activities. For youth, nightlife activities are not just moments to find fun, but also build their identity. Malioboro is one of the places in Yogyakarta that is a destination for youth to do night activities. This research focuses on nightlife activities carried out by youth in Malioboro during the COVID-19 pandemic. In addition, this study seeks to see the need for youth to have space for expression and shape their identity. Based on this focus, this study looked at how a Malioboro Area space can be reproduced by youth through activities at night to meet their needs. This research uses the case study method, whereresearchers conduct an in-depth analysis of a case through and tracing a number of data that is limited in time and place.  Based on the findings of field data, it shows that activities at night in Malioboro for youth are a necessity even during a pandemic. They see the Malioboro Area as having an appeal through symbols that are displayed as the identity of the space. So the youth use Malioboro as a place to express according to their wishes in taking advantage of free time at night. Based on these findings, it can be explained that youth and a space are related in the formation of identity.
Pemaknaan "Ngevent" dengan Perspektif Student Volunteering: Menjadi Mahasiswa yang Lebih ‘Bernilai’ dalam Masa Transisi Anak Muda
Authors: Siregar Achmed Faiz Yudha
Published: July 2023

This article focuses on individual reflections on ‘ngevent’, which later became ‘slang’ among youths who represent their existence in seeking experiences outside of the campus as volunteers in art and cultural events during their status as students in Yogyakarta. This study is based on a phenomenological study, which uses in-depth interviews, participant observation, and document studies in data collection and is carried out after selecting several participants who have similar experiences in this topic. The findings based on this study show that this experience is proven to be self-enhancing as well as helping to form the values that are attached to identity as agents in youth work who continue to progress through social life. This article explains how the experience is interpreted through construction of the meaning of ‘ngevent’ related to perspectives, motivations, and benefits, as a youth in the context of an late modernity societies that is close to the risk of uncertainty of youth transition in Furlong & Cartmel’s. By using the phenomenological approach with student volunteering perspective and analytical framework of reflexive identity presented by Anthony Giddens help me explain how the social process and the self-construction of the experience, this study found 3 levels of aspect as a result to understand the meaning on the process of ‘ngevent’: External Consciousness, Internal Consciousness, and Oriented Motive & Outcomes. in this end, such experiences can help youth reflection the process & minimize the risk of ‘uncertainty’ in the transition from education to work.
Process Study on the Preparation of Degradable Antifouling Paint Coatings by Solvent Method
Authors: Yu Xincheng , Kou Mingzhe , Wang Jin
Published: July 2023

Marine anti-fouling coatings have been widely used as one of the effective methods to prevent marine fouling organisms from adhering to the surfaces of various marine facilities. The main types are self-polishing anti-fouling coatings and low surface energy anti-fouling coatings, and biomimetic antifouling paint. Due to the increasing awareness of environmental protection, the anti-fouling coatings harmful to the environment have been gradually banned, so the research and development of new anti-fouling coatings has become the primary direction of development.In this paper, polycaprolactone and PLA were used as resin base materials, capsaicin as bio-friendly anti-fouling agent, starch as polysaccharide additive, the experimental samples were prepared by adjusting the mixture ratio of these materials. The experiment of adding starch and unadded starch was carried out by using Magnetic stirrer and other experimental equipment to simulate the hanging board method on the sea and observed and recorded, the effect of Starch on the hydrolysis of anti-fouling coatings using single component or blends of biodegradable materials such as polycaprolactone, polylactic acid (PLA) as resin matrix was investigated.The results showed that starch could promote the hydrolysis of resin-based materials such as PCL, and the solubility of PCL and PLA in chloroform was obtained, a preparation method of antifouling coating for marine static culture equipment was obtained.
Mediation through Computerized Dynamic Assessment (C-DA) for Second and Foreign Language Learning: A Literature Review
Authors: Liu Xiaotian , Hu Miao
Published: July 2023

This paper examines research on the effects and roles of computerized dynamic assessment (C-DA) in mediating second language (L2) learning and development. The review synthesizes studies on C-DA interventions for developing language skills including reading comprehension, vocabulary and grammar skills. C-DA studies indicate the promotion of language development, but the effectiveness is not all attributed to C-DA mediations. Effectiveness seems dependent on both C-DA and additional factors like noticing skills or teacher mediation. In these studies, most C-DA prompts are pre-constructed and not fully attuned to learners’ zone of proximal development, and some C-DA studies address this by complementing C-DA with human mediator interaction. Given the limited number of C-DA studies, the findings of this review are limited. More research is needed, especially on integrating human and computer mediation. However, this review offers implications for designing responsive C-DA platforms to better attune to learners’ needs.