bluuebunny/crossref_metadata_2025 huggingface dataset:
Vascular comorbidity is associated with decreased cognitive functioning in inflammatory bowel disease
Authors: Patel Ronak , Marrie Ruth Ann , Bernstein Charles N , Bolton James M , Graff Lesley A. , Marriott James J , Figley Chase R , Kornelsen Jennifer , Mazerolle Erin L , Uddin Md Nasir , Fisk John D.
Published: October 2022

Background: Reports of cognitive impairment in inflammatory bowel disease (IBD) have been mixed. IBD and cardiovascular disease are often co-morbid, yet it remains unknown whether vascular comorbidity confers a risk for decreased cognitive functioning, as observed in other populations.
Methods: Participants with IBD were recruited from a longitudinal study of immune-mediated disease. Participants were administered a standardized neuropsychological test protocol, evaluating information processing speed, verbal learning and memory, visual learning and memory, and verbal fluency/executive function. Cognitive test scores were standardized using local regression-based norms, adjusting for age, sex, and education. Vascular risk was calculated using a modified Framingham Risk Score (FRS). We tested the association between FRS and cognitive test scores using a quantile regression model, adjusting for IBD type.
Results: Of 84 IBD participants, 54 had ulcerative colitis and 30 had Crohn’s disease; mean (SD) age was 53.36 (13.95) years, and a high proportion were females (n = 58). As the risk score (FRS) increased, participants demonstrated lower performance in information processing speed (β=-0.12; 95% CI: -0.24, -0.006) and verbal learning (β=-0.14; 95% CI: -0.28, -0.01) at the 50th percentile. After adjusting for IBD type, higher FRS remained associated with lower information processing speed (β=-0.13; 95% CI: -0.24, -0.03).
Conclusion: Vascular comorbidity is associated with lower cognitive functioning in persons with IBD, particularly in the areas of information processing speed and verbal learning. These findings suggest that prevention, identification, and treatment of vascular comorbidity in IBD may play a critical role for improving functional outcomes in IBD.
A prediction method for influenza during COVID-19 in Shanxi Province, China: LSTM-SARIMA hybrid model based on Singular Spectrum Analysis
Authors: Zhao Zhiyang , Zhai Mengmeng , Li Guohua , Gao Xuefen , Wang Xuchun , Ren Hao , Cui Yu , Qiao Yuchao , Ren Jiahui , Chen Limin , Qiu Lixia
Published: October 2022

To handle the difficulties of modeling and prediction caused by the abnormal influenza sequence during COVID-19, this study established a hybrid prediction model of Long-Short Term Memory neural network (LSTM) and seasonal autoregressive integrated moving average (SARIMA) based on Singular spectrum analysis (SSA), which provided an effective scientific basis for the high-precision prediction of influenza in Shanxi Province during the COVID-19. Seasonal-trend decomposition using Loess (STL) was adopted to analyze the season characteristics of the ratio of weekly influenza-like illness (ILI) patients in Shanxi Province, China, from the 14th week in 2010 to the 13th week in 2021. The SARIMA model, the LSTM model and the LSTM-SARIMA hybrid model based on SSA were established to predict the influenza in Shanxi Province during the COVID-19. Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) were used to evaluate the performance of the models. Affected by the COVID-19, the influenza time sequence in Shanxi Province has been complicated since the beginning of 2020, with the peak incidence much lower than before. Compared with those of the SARIMA model, the MAE and MAPE of the LSTM-SARIMA hybrid model based on SSA decreased by 28.9 and 32.2%, respectively, in fitting performance; in terms of prediction performances, the MAE and MAPE decreased by 52.5 and 52.1%, respectively. Compared with those of the LSTM model, the MAE and MAPE of the LSTM-SARIMA hybrid model based on SSA decreased by 26.2 and 27.5%, respectively, in fitting performance; in terms of prediction performances, the MAE and MAPE decreased by 35.0 and 35.3%, respectively. The fitting and prediction performances of the LSTM-SARIMA hybrid model based on SSA were better than those of the SARIMA and the LSTM models. Generally speaking, we can apply the LSTM-SARIMA hybrid model based on SSA to the prediction of influenza during the COVID-19, and offer a leg-up for public policy.
Family UNited: Piloting of a new universal UNODC family skills programme to improve child mental health, resilience and parenting skills in Indonesia and Bangladesh
Authors: Haar Karin , El-Khani Aala , Narotama Narendra , Hussain Amir , Fitri Eva , Badrujaman Aip , Wahyuni Eka , Naheeaan Shah Mohammad , Yassine Ali , Maalouf Wadih
Published: October 2022

Background
Family is one of the most influential social institutions and caregivers act as the main protective factors for children’s mental health and resilience skills. Family skills programmes support caregivers to be better parents and strengthen positive age-specific and age-appropriate family functioning and interactions. We developed a universal, brief and light programme for implementation in low-resource settings; the Family UNited (FU) programme and conducted a pilot study to show feasibility of implementation, replicability and effectiveness in improving family functioning, child behaviour and resilience.
Methods
We recruited caregivers with children aged 8-14 years through schools in East Java, Indonesia and Dhaka, Bangladesh to the FU programme. Demographic data, emotional and behavioural difficulties of children, child resilience and parental skills and family adjustment measures were collected from children and caregivers before, 2 and 6 weeks after the intervention. Outcome was assessed through the SDQ (Strengths and Difficulties Questionnaire), PAFAS (Parenting and Family Adjustment Scales) and CYRM-R (Child and Youth Resilience Measure).
Results
We enrolled 29 families in Bangladesh and allocated 37 families to the intervention and 33 to the control group in Indonesia. Overall, there was no effect over time in the control group on any of the PAFAS subscales, whereas significant reductions in scores were found on six of the seven subscales in either country in the intervention group, most prominently in caregivers with higher scores at baseline. We found highly significant reductions in total SDQ scores in the intervention group in both countries, whereas there was no effect over time in the control group in Indonesia. Boys in the intervention group in Indonesia and in Bangladesh seemed to have benefitted significantly on the SDQ as well as the total resilience scale. Overall, on the CYRM-R, particularly children below the 33rd percentile at pre-test benefitted substantially from the programme.
Conclusions
The implementation of a brief family skills programme was seemingly effective and feasible in resource-limited settings and positively improved child mental health, resilience and parenting practices and family adjustment skills. These results suggest the value of such a programme and call for further validation through other methods of impact assessment and outcome evaluation.
Trial registration
Clinical Trial Registration: ISRCTN (number pending payment, technically approved), retrospectively registered, 22 September, 2022.
Quantum spin Hall states and topological phase transition in germanene
Authors: Bampoulis Pantelis , Castenmiller Carolien , Klaassen Dennis , Mil Jelle van , Liu Yichen , Liu Cheng-cheng , Yao Yugui , Ezawa Motohiko , Rudenko Alexander , Zandvliet Harold
Published: October 2022

The realization of the topological field-effect transistor requires an electric field-induced transition from a topological state with dissipationless conductive channels (`On') to a trivial insulator state (`Off'). Monoelemental and buckled quantum spin Hall insulators with large topological band gaps are ideal candidates to investigate topological phase transitions. We provide compelling experimental evidence that low-buckled epitaxial germanene is a quantum spin Hall insulator with a large bulk gap and robust metallic edge states. The low-buckled structure of germanene allows for topological phase transitions to take place. Upon the application of a critical transversal electric field, the topological gap closes and germanene becomes a Dirac semimetal. Increasing the electric field further results in opening of a trivial gap and disappearance of the edge states. This reversible electric field-induced switching of the topological state and the sizeable gap make germanene suitable for room-temperature topological field-effect transistors, which could revolutionize low-energy electronics and spintronics.
Ultrasonographic assessment of diaphragmatic function in preterm infants on Non-Invasive Neurally Adjusted Ventilatory Assist (NIV-NAVA) compared to Nasal Intermittent Positive-Pressure Ventilation (NIPPV): A prospective observational study
Authors: Elkhouli Mohamed , Tamir-Hostovsky Liran , BSc Jenna Ibrahim , Nasef Nehad , Mohamed Adel
Published: October 2022

Purpose of the study: NIV-NAVA mode for respiratory support in preterm infants is not well-studied. The aim of this study was to describe diaphragmatic function, diaphragmatic excursion (DE) and thickness fraction (DTF), in preterm infants < 30 weeks’ gestation supported by NIV-NAVA compared to NIPPV using bedside ultrasonography.
Methods: In this consecutive prospective study, DE, diaphragmatic thickness at end of expiration (DTexp), end of inspiration (DTins), and DTF were assessed using bedside ultrasound. Lung aeration evaluation using lung ultrasound score (LUSs) was performed for the two groups. Diaphragmatic measurements and LUSs were compared for the 2 groups (NIV-NAVA group versus NIPPV group). Statistical analyses were conducted using SPSS software version 22.
Results: Out of 70 infants evaluated, 40 were enrolled. Twenty infants were on NIV-NAVA (mean [SD] study age of 25.7 [0.9] weeks) and 20 infants were on NIPPV (mean [SD] study age of 25.1 [1.4] weeks p= 0.15). Baseline characteristics and respiratory parameters at the time of the scan, showed no significant difference between groups. DE was significantly higher in NIV-NAVA with a mean SD 4.7 (1.5) versus 3.5 (0.9) in NIPPV, p=0.007. Additionally, the mean (SD) of DTF for the NIV-NAVA group was 81.6 (30) vs 78.2 (27) for NIPPV group [p=0.71]. Both groups showed relatively high LUSs but no significant difference between groups [12.8 (2.6) vs 12.6 (2.6) p=0.8].
Conclusion: Preterm infants managed with NIV-NAVA showed significantly higher DE compared to those managed on NIPPV. Longitudinal studies to assess diaphragmatic function over time are needed.
Trial Registry: Clinicaltrials.gov (NCT05079412)
Date of registration 09/30/2021
Abstract publication/presentation: Portions of this paper were presented at the Pediatric Academic Society (PAS) meeting in Denver, USA, May 2022 as poster presentation as well as at the 4th Neonatal Research Day- Toronto, Canada on April, 2022 as an oral presentation.
Bidirectional Formation-involved Consensus for Uncertain Multi-Lagrange Systems under Directed Signed Topology Networks
Authors: Ma Xinru , Liu Jingyi , Li Hengyu , Xie Yonghao , Zhang Tiehui , Wang Zhaoyan , Wang Yueying , Liu Jun , Xie Shaorong , Luo Jun
Published: October 2022

To better describe the complex behaviors of multi-agent systems (MAS), this paper proposes a bidirectional formation-involved (FI) consensus control method for multi-Lagrange systems (MLS). It primarily considers the Lagrange systems with uncertain parameters and employs the bipartite topology in communication network. Under bidirectional formation control, the validity of this control protocol and the stability of the MLS are verified, by determining the consistency convergence of the Lyapunov function of the systems. For the given stabilized MLS, the leader is added with first-order linear system to provide trajectory guidance. With cooperative-competitive interactions, MLS perform the FI complex behavior considering trajectory tracking. The experiment part provides sufficient simulation examples that are selected to be consistent with the systems in the theoretical part.
Development and Validation of a Stability Indicating RP-HPLC Method of a Synthetic Thiophene Chalcone and its degradation products
Authors: Raheja Radhika , Pise Nikita , Prabhu Arati
Published: October 2022

The current paper describes a simple accurate, precise, and robust reversed-phase high-performance liquid chromatographic-stability-indicating assay method using isocratic elution for quantitative estimation of a 1-(4-benzyloxy)phenyl-3-(2-thienyl)prop-2-en-1-one; a benzyl thiophene chalcone (TC) synthesized in our laboratory for anti-Alzheimer’s activity and its degradation products obtained from forced degradation studies. The method was developed using Thermo Scientific C18 column (250 x 4.6 mm, 5 µm) as stationary phase and sodium acetate buffer (pH 3.0): acetonitrile (40:60, v/v) as the mobile phase at 1 ml/min flow rate and 280 nm as detection wavelength. TC eluted at a retention time of 27.4 min. The method was validated as per ICH guidelines. Linearity was obtained in the range of 5–15 µg/ml, the limit of detection was found to be 0.323 µg/ml and the limit of quantification was found to be 0.978 µg/ml. Inter-day and intra-day precision was 0.59% and 0.90% respectively. TC was subjected to forced degradation studies in basic, acidic, oxidative, thermal, photolytic, and thermal humidity stress conditions in accordance with ICH guidelines. It was found to be stable under thermal and thermal-humidity stress but degraded to different extents under acidic and basic hydrolytic conditions, oxidative stress, and photolytic conditions.
Analysis of characteristics and prognostic factors among young patients with lung cancer
Authors: Li Mengqi , Yang Hao , Mu Junhao , Li Weiyi , Yang Li , Mei Tonghua
Published: October 2022

Purpose
To assess characteristics and prognostic factors among 18–40-year-old patients with lung cancer.
Methods
A retrospective analysis was performed using clinical data of 18–40-year-old patients diagnosed with primary lung cancer in the Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of the First Affiliated Hospital of Chongqing Medical University from 1 January 2015 to 1 January 2021. The patients’ characteristics and prognostic risk factors were analysed.
Results
This study included 284 patients (74 males and 210 females). Their median age was 36 years. In total, 77.11% of patients were asymptomatic at initial diagnosis. Moreover, 14.08%, 3.87% and 10.21% of patients had a smoking history, personal tumour history and family tumour history, respectively. Furthermore, 59.86% of the lesions were located on the right side, 58.10% were located in the upper lobe, 88.03% were sized ≤ 3 cm, 93.31% were adenocarcinomas, 84.51% were TNM stage 0-I and 90.85% required surgical treatment. Significant differences in smoking history, cough and expectoration, tumour density, tumour size, pathological type, disease stage and treatment modalities were noted between men and women. Multivariate analysis revealed that smoking history, disease stage, surgical treatment and targeted therapy were independent prognostic factors for overall survival.
Conclusion
The onset of lung cancer in 18–40-year-old people was insidious, and the symptoms were atypical, mainly in patients with early adenocarcinoma. Surgical treatment and targeted therapy were factors improving prognosis. Early diagnosis and treatment are thus crucial for improving the prognosis of young patients with lung cancer.
Particulate organic carbon (POC) estimation and algorithm development in northeast Arabian Sea coastal water
Authors: Sarangi R. K. , Jaiganesh S. N.N. , Patel Bimalkumar R. , Prajapati Apurva , Patel Hitesh D.
Published: October 2022

In situ sampling and analysis for water quality and bio-optical parameters carried out in the northeast Arabian Sea, in Diu and Daman coastal waters during February and August 2021. The in situ sampled water analysed to estimate chlorophyll, nutrients, Particulate Organic Carbon (POC) in the study area. The bio-optical parameters, normalized water leaving radiance (Lwn) and remote sensing reflectance (Rrs) retrieved with the operation of underwater hyperspectral radiometer (Satlantic/Wetlabs inc.). The main objective of the work was to develop POC algorithm using in situ radiometer derived Rrs for selected wavelengths in visible regions and linking the band ratios to in situ POC data. In Diu, total 11 stations data collected and produced POC range (44–608 mg m− 3). These 11 points POC data correlated with Rrs band ratios using 2nd order polynomial function and indicated coefficient of determination (R2 values 0.37, 0.34 and 0.13). This correlation was also made using 3rd order polynomial fit and indicated R2 values 0.41, 0.42 and 0.26. The same datasets were observed with 3-Dimensional correlation between Rrs(490/555), Rrs(443/555), Rrs(510/555) and POC using linear, paraboloid, gaussian and Lorentzian function fit, which showed improved R2 values ranging 0.34 to 0.66. The data from Daman added to Diu data (total 18 points), which resulted with further better correlation (R2 = 0.75, RMSE = 9.12) with higher range of POC upto 2600 mg/m3. The Modis-Aqua satellite derived POC data for our in situ stations for the sampling dates ranged 392–411 mg m− 3 as compared to our in situ data range 44–608 mg m− 3. Out of these different POC algorithms inter-comparison and satellite data, it is observed mandatory to have regional POC algorithms with sufficient in situ data points.
HDACs/mTOR inhibitor synergizes with pyrotinib in HER2-positive pancreatic cancer through degradation of mutant P53
Authors: Mao Tiebo , Zhang Xiaofei , Xu Haiyan , Zhang Xiao , Ge Weiyu , Li Shumin , Ma Jingyu , Yue Ming , Xue Shengbai , Cui Jiujie , Wang Liwei
Published: October 2022

Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among whichHER2 receptor tyrosine kinase inhibitor pyrotinib as treatment targets has not be decided.
Methods
Anti-PDAC efficacy of pyrotinib was evaluated both in vitro and in vivo using both cell lines and patient-derived xenografts. By screening a large-scale library of 1453 compounds, we identified HDACs/mTOR inhibitor 1 as a promising candidate to synergize with pyrotinib. The combination therapy was evaluated in vitro and in vivo in multiple cell lines and animal models. Furthermore, RNA-seq analysis was performed to reveal the latent molecular mechanism of combination therapy.
Results
In our study, pyrotinib monotherapy was found to be inefficient to anti-PDAC which exhibited limited anti-proliferation effect in vitro and in vivo. Through therapy combined with HDACs/mTOR inhibitor 1, pyrotinib triggered intense apoptosis in PDAC both in cell lines and animal models. Mechanistic analyses revealed that mutant P53 degradation mediated by HDAC inhibition synergized with HER2 and mTOR inhibition.
Conclusions
In conclusion, identification of HDACs/mTOR inhibitor as a synergistic inhibitor, provides a potent therapeutic strategy that targets HER2-positive pancreatic cancer.
Comparative aerobiological study between two stations located at different points in a coastal city in southern Spain
Authors: Ruiz-Mata Rocío , Trigo María del Mar , Recio Marta , de Gálvez-Montañez Enrique , Picornell Antonio
Published: October 2022

Due to the increase in allergies, aerobiological studies carried out in cities are essential to keep the population informed about the pollen atmospheric concentrations detected. However, the high cost and complexity of aerobiological studies often means that the information is generated from a single sampling point what may not be representative of the entire city. So, the precision and functionality of the information and alert systems for allergy sufferers can be reduced. This effect may be increased in coastal cities or in those with an asymmetric growth. In this study, the data obtained by two volumetric pollen traps, located in the coastal city of Malaga (Spain) were analyzed. One of the pollen traps was situated in the city center while the other was in the outskirts of the city, 5 km away from the first. Despite being located within the same city, the data obtained from both collectors showed significant differences in the relative abundance and annual integrals of the main pollen types, as well as in the periods in which elapse their main pollen seasons, probably due to being located in areas with quantitative differences in land uses. These differences were more notable in the case of ornamental plants, weeds that usually appear in brownfields sites, and some taxa that predominate in the agro-forestry areas of the outskirts. For all the above, we consider that it is important to keep operational several sampling points in cities of a certain magnitude to provide more detailed information about atmospheric pollen concentrations.
Four novel large deletions and complex variants were identified in α-globin locus in Chinese population
Authors: Bao Xiuqin , Wang Jicheng , Qin Danqing , Yao Cuize , Liang Jie , Liang Kailing , Zeng Yukun , Du Li
Published: October 2022

Background: At present, the usual methods used to detect a-thalassemia mutations are confined to detect the common mutations, which may easy to result in misdiagnosis or missed diagnosis. Single molecule real time sequencing (SMRT) enables long-read single-molecule sequencing with high detection accuracy, and long-length DNA chain reads in high-fidelity reads mode.
Methods: Herein, we used SMRT to detect rare and complex variants in a-globin locus in four individuals whose hematological data indicated microcytic hypochromic anemia but conventional thalassemia detecting result was negative. Multiplex ligation-dependent probe amplification (MLPA) and droplet digital polymerase chain reaction (ddPCR) were used to confirm the results of SMRT.
Results: We found 4 novel large deletions ranging from 23 kb to 81 kb in a-globin locus, among which one patient also has a duplication inserted in the deletional fragment. In addition, one patient with 27.31 kb deletion on chromosome 16 (hg 38) was also detected to be abnormal hemoglobin Siriraj (Hb Siriraj).
Conclusion: We first identified the four novel deletions in a-globin locus by using SMRT. Given that conventional methods may lead to misdiagnosis or missed diagnosis, SMRT served as a good method to discover rare and complex variants in thalassemia, especially in prenatal diagnosis.
Methods for meta-analysis and meta-regression of proportions: concepts and tutorial with Stata command metapreg
Authors: Nyaga Victoria Nyawira , Arbyn Marc
Published: October 2022

Background: Despite the widespread use of meta-analysis of proportions, its rationale, certain theoretical and methodological concepts are poorly understood.The framework of logistic regression is well-established and provides a natural and optimal model for meta-analysis, network meta-analysis, and meta-regressionof proportions. Nonetheless, classical tools for meta-analysis of proportions based on approximation to the normal distribution continue to dominate.
Methods: We explain the rationale and concepts essential in understanding statistical methods for meta-analysis of proportions. We then present metapreg; a flexible model-based tool with advanced statistical procedures to perform ameta-analysis, network meta-analysis, and meta-regression of proportions in Stata. The tool implements the logistic and the logistic-normal regression, andmarginal standardization to yield population-averaged estimates. Finally, we demonstrate using metapreg with data from four published meta-analyses; a)cure rate of treatment for cervical pre-cancer using cold coagulation, b)incomplete excision of cervical precancer as a predictor of treatment failure, c)effect of geographical area on the protective effect of BCG vaccination againsttuberculosis and d) response rate to treatment of acute mania in adults withdiverse drugs.
Conclusion: metapreg is an efficient and user-friendly statistical tool dedicatedt o meta-analysis, network meta-analysis and meta-regression of binomial data. It allows both continuous and categorical explanatory covariates including relevant interactions to explain the variability in the proportions.
Leveraging Technology To Diagnose Alzheimer's Disease: A Meta Analysis
Authors: Kruse Clemens Scott , Mileski Michael M. , Wilkinson Reagan , Larson Britney , Samson Roger , Castillo Taylor
Published: October 2022

Background:About 50 million people worldwide suffered from dementia in 2018 – two-thirds of those with Alzheimer's Disease (AD). By 2050, this number is expected to rise to 152 million – which is slightly larger than the country of Russia. About 90% of these people are over the age of 65, but early-onset dementia can occur younger ages. The objective of this meta-analysis is to objectively analyze the effectiveness of health information technology to diagnose AD. We analyzed data from studies published over the last 10 years to meet this objective: Cost, efficiency, accuracy, acceptability (by physician and patient), patient satisfaction, and barriers to adoption.Methods:Four research databases were queried (PubMed, CINAHL Ultimate, Web of Science, and ScienceDirect). The study was conducted in accordance with a published protocol, the Kruse Protocol, and reported in accordance with PRISMA (2020).Results:Ten technological interventions were identified to help diagnose AD among older patients, and some involved a combination of methods (such as MRI and PET). The average sample size was 320. These 10 interventions were identified as accurate, non-invasive, non-stressful, in expensive, convenient, and rapid. Only one intervention was identified as ineffective, and this same intervention was used effectively in other studies. Barriers identified were cost, training, expense of travel, and requires physical presence of patient. The weighted average sensitivity was 85.16%, specificity was 88.53, and the weighted average effect size was 0.7339.Conclusion:Technological innovation can accurately diagnose AD, but not all methods are successful. Providers must ensure they have the proper training and familiarity with these interventions to ensure accuracy in diagnosis. While the physical presence of the patient is often required, many interventions are non-invasive, non-stressful, and relatively inexpensive.
Ethnobotanical study of medicinal plants used to treat livestock ailment in Delomena district southeast Ethiopia.
Authors: Gobana Awal Hussein , Jilo Sufian Abdo
Published: October 2022

Traditional knowledge on the use of medicinal plants is in danger of extinction because of different changes taking place all over the world including Ethiopia and thus there is a need for its immediate documentation for the purpose of conservation, sustainable utilization and development. Thus, an ethnobotanical study was conducted in Dalomana District, Oromia Regional State of Ethiopia to document and analyze local knowledge on medicinal plants used for the treatment of animal diseases. The overall objective of the study were to investigate ethnobotany of traditional medicinal plants used to treat livestock diseases in Dalomana district, Bale Zone, Oromia, Ethiopia. Data were collected between June, 2021 and February, 2022 mainly through semi-interviews conducted with purposively selected informants. Data collected mainly included demographic information of respondents, local names of medicinal plants, plant parts used, preparation methods, mode of applications, diseases treated, and habit and habitat of the reported plants. Based on data obtained through interviews, Informant Consensus Factor (ICF) values were computed. A total of 55 medicinal plants used to manage livestock ailment were reported by informants in the Dalomana District. Herbs were commonly used in the preparation of remedies. Leaf was the most frequently utilized plant part accounting for 49.1% of the total reported medicinal plants. The majority (69.0%) of the medicinal plants used in the study District were uncultivated ones mainly harvested from edges of forests and bushlands, roadsides, river banks and grasslands. High ICF values were obtained for ophthalmological (0.82), dermatological (0.79), febrile (0.77) and gastro-intestinal ailments (0.77). The current study shows that there is still rich traditional knowledge on the use of plants to control various animal diseases in study District. However, such claim needs to be scientifically verified with piriority given to medicinal plants used in the treatment of ailment catagories with high ICF values as such plants are considered to be good candidates for further pharmacological evaluations
Cost Benefit Analysis Of Traditional Healer A Case Study At Dalomana Town In Bale Zone Southeast Ethiopia.
Authors: Gobana Awal Hussein , Shure Hasan Abdela , Kecho Abdo Hussein , Adem Mohammed Edris , Abdurahman Taha Kedir , Jilo Sufian Abdo , Nigatu Abay
Published: October 2022

Traditional medicine refers to health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illnesses or maintain well-being. A reconnaissance survey was conducted between March 25 to May 5, 2022. The main objective of the study intends to examine the costs of input, total income and expenditure of traditional healer and identify the economic benefits of those applications of traditional medicine for the country Dalomana Southeastern, Ethiopia. The study sites were selected depending on recommendation from elders, local authorities, and altitudinal range. Thus, the study was carried out in eight PA from two agro-climatic zones. Dallo Manna. The income they generated from their jobs is recorded. The daily income is recorded. The major incomes are direct selling of the drugs as pharmacists and amount of earns they get from diagnosis and treatment of patients. Some practitioners also sell the other products which taken with drugs such as honey and other oil. The total benefit (profits) from the job is analyzed with an average of 650.8 birr daily generated as income and annually 237542 birr is estimated to be as total profit for traditional healer. Analysis of production cost structure revealed that the highest proportion of the production costs across the lead traditional healer for used health related technology and neglect technological and coset went to cost of labor (58%) and different technological activities (22%). As opposed to the traditionally used application of technology was produce more than normal amount of birr without applications., the current study indicated that reduced uses of technology for benefits increased yield per unit area but traditional healer challenged the researchers to improve the feasibility of using reduced seed rate for both row planting and broadcasting.
Distinct time trends in colorectal cancer incidence in countries with SDI levels from 1990 to 2019: An age–period–cohort analysis for the Global Burden of Disease 2019 study
Authors: Zhang Yan , Li Pu–Heng , Ding Yu–Wei , Kong Yang , Zhu Xiao-Feng , Tian Yang , Zhang Qing–Wei
Published: October 2022

Introduction: The burden of colorectal cancer (CRC) plays a pivotal role in the global cancer epidemic. Our study reported the incidence trends in CRC and the associated effects of age, period, and birth cohort in 204 countries and territories over the past 30 years.
Methods:The incidence data of CRC wereextracted from the Global Burden of Disease Study (GBD) 2019. We performed the age–period–cohort (APC) model to estimate the overall annual percentage change (net drift) in the incidence rate, the annual percentage change by age group (local drift), and the relative risk (period and cohort effects) of the period and cohort in CRC during 1990–2019. This approach allows examining and distinguishing age, period, and cohort effects in incidence and potentially distinguishing colorectal cancer gaps in prevention and screening.
Results: In 2019, the incidence of CRC was 2.17 (95% UI 2.00–2.34) million, of which China, the United States of America, and Japan had the highest incidence population, accounting for 45.9% of the global population. The age–standardized incidence rate (ASIR) was 26.7 (95% UI 28.9–24.6) per 100,000 people, of which 30 countries had an incidence rate greater than 40.0 per 100,000 people. From 1990 to 2019, the middle SDI region had the largest increase in incidence rate, with a net drift of 2.33% (95% CI 2.2%–2.46%, P< 0.001). Globally, the incidence population was concentrated in the age group of 50–69 years, and the age group of 30–34 years had the largest increase in incidence rate (local drift 1.19% (95% CI 1.01%–1.37%)). At the same time, the sex and age distributions of CRC incidence had significant heterogeneity across regions and countries. In the past 30 years, the incidence rate in 31 countries has been well controlled (net drift <0), and most of them were concentrated in high–and high–middle–SDI regions, such as Australia, Czechia, and Belgium, and the relative risk of incidence generally improved over time and consecutive young birth cohorts. CRC incidence showed an unfavorable trend (net drift ≥1%) in 89 countries, of which 27 countries were more significant (net drift >2%), mostly concentrated in the middle SDI region, such as China, Mexico, and Brazil, and the risk of period and birth cohort was unfavorable.
Conclusion: Globally, the incidence of CRC has shown an overall upward trend over the past 30 years, with the exception of some countries with higher SDI values. Significant age–period–cohort differences were observed in the risk of incidence in CRC worldwide. Effective prevention and control policies need to take into account the age–period–cohort effect characteristics of different regions.
Isolated cardiac hydatid cyst in interventricular septum: a case report and literature review
Authors: Li Tiange , Ling Yunfei , Qian Yongjun
Published: October 2022

Background: Human hydatid disease occurs after infection with Echinococcus granulosus, mainly involves liver and lung, while hydatid involves heart is infrequent. A great majority of hydatid diseases could be asymptomatic, and incidentally found through examination. Here, we reported a woman who suffered an isolated cardiac hydatid cyst located at the interventricular septum.
Case presentation: A 48-year-old woman presented intermittent chest pain was admitted to the hospital. Imaging examination revealed a cyst located at the interventricular septum near the right ventricular apex. Considering medical history and serological results, cardiac hydatid disease was diagnosed. The cyst was successfully removed, while pathological biopsy confirmed the infection of Echinococcus granulosus. Postoperative course was uneventful, the patient was discharged from hospital without complications.
Conclusion: For symptomatic cardiac hydatid cyst, surgical resection is necessary to avoid progression of disease. During surgical procedure, appropriate methods to reduce the potential risk of hydatid cyst metastasis are essential. Besides surgery, combined with regular drug therapy is an effective strategy to prevent reappearance.
The dielectric property and thermal conductivity properties of epoxy composite filled by P-CdS with patterned surface structure
Authors: Yang Juxiang , Jia Yuan , Li Xiaoyan , Li BeiBei , Sun Ping
Published: October 2022

In order to endow epoxy resins (EP) with good thermal conductivity under the condition of maintaining its good dielectric properties, the new poly(N-isopropylacrylamide-co-methacrylic acid)(P(NIPAM-co-MAA))/CdS (P-CdS) microspheres with patterned surface structures was synthesized by reverse suspension polymerization technique and exogenous deposition method using the P(NIPAM-co-MAA) microgels as the template. The P-CdS microspheres with patterned surface structure were then used as modifier to prepare the P-CdS/EP composites. The chemical structure and surface morphologies of the prepared P-CdS and P-CdS/EP composites were characterized by the SEM, XRD and TGA, and influence of the P-CdS content on the dielectric properties, thermal conductivity and thermal resistant properties of P-CdS/EP composites were also studied. The results showed that the slight addition of P-CdS can highly improve the thermal conductivity and thermal resistance of P-CdS/EP composites, as well as endow EP with high dielectric constant and low dielectric loss at high frequencies. This phenomenon can be attributed to the good dispersibility and excellent electrothermal properties of P-CdS. The purpose of this study is aiming to lay a foundation for the microelectronic components application of EP in high frequency.
Accuracy and precision of certified Glucometer-Strips System Contour Plus One in clinical practice
Authors: Chlup Rudolf , Zálešáková Hana , Doubravová Blanka , Ďurajková Emilia , Nezval Martin , Gottwaldová Jiřina , Zapletalová Jana
Published: October 2022

Aims 1.To revise the accuracy and precision of glucometer-strips system (GSS) in a professional routine. 2. To support the feasibility of capillary plasma glucose (cPG) monitoring.
Methods Prospective single-centre study. Triplets of cPG were investigated on GSS Contour Plus One (Ascensia, Switzerland) using glucosedehydrogenase strips. To obtain one triplet, one LOT of strips was used in three glucometers Contour Plus One. Following the cPG readings, venous blood was taken into a Grainer tube to measure venous plasma glucose (vPG) on Cobas Integra 400 analyzer using hexokinase. Software IBM SPSS Statistics for Windows, V. 23.0 was applied. A total of 258 pairs of cPG vs vPG were compared using Wilcoxon signed rank test with Bonferroni correction. P<0.05 was considered significant. Precision was estimated using SD of average differences between individual cPG measurements.
Results Deviations of cPG measured on GSS Contour Plus One from vPG (in range ≥5.55 mmo/L) measured on Cobas Integra Analyser were -0.63±0.71 mmol/L (mean±SD). Number of cPG values measured on Contour Plus One within the required interval ±15% of vPG values was 200/207 (96.6%). For vPG <5.55 mmol/L the required interval of ±0.83 mmol/L was reached in 51/51 (100%) cPG values measured on GSS Contour Plus One. PG precision/variability in triplets of GSS Contour Plus One was demonstrated by SD 0.204±0.247 mmol/L.
Conclusions Required accuracy and precision of GSS Contour Plus One in clinical practice was confirmed and corresponds to the Requirements for blood-glucose monitoring systems for self-testing in managing diabetes mellitus ISO 15197 (2015). In addition to sustainable reviews of registered GSS also experienced data communication between health care professionals and GSS users should be considered.
Cross species horizontal gene transfer of bacterial genes during human evolution controls human cell proliferation through long non coding RNA’s, and is responsible for gallbladder carcinogenesis.
Authors: Pandey Manoj , Rajpoot Monika , Dixit Ruhi , Singh Pooja , Shukla Vijay Kumar
Published: October 2022

Summary

Background

Gallbladder cancer is the commonest cancer of the bile duct, the etiopathogenesis is still debatable. Non coding RNAs are implicated in various carcinogenesis however their role in gallbladder cancer is still not clear.

Methods

Transcriptomic data from gallbladder cancer patients was analyzed for differential expression of long non coding RNA (lncRNA), the data was subjected to cross-species phylogenetic analysis and blast with the bacterial and ancient human genome. Pathway analysis, gene-gene interactions and data and text mining was done for non-conserved non coding genes.

Findings

Of the 16 lncRNA identified as differentially expressed, 7 were found to be phylogenetically of bacterial origin appeared to be acquired by horizontal gene transfer during evolution. These genes were identified in both Homo heidelbergensis and Homo neanderthalensis with dissimilarities. Functional analysis of these gene showed them to regulate various biological and genetic process that appear to promote gallbladder carcinogenesis.

Interpretation

This is the first study that shows that 7 of the human lncRNA are probably of bacterial origin and has been passed to Homo sapiens through ancestry and part of these has been acquired during human evaluation. These genes regulate the transcription and post transcriptional vital RNA, protein functions and thus may induce gallbladder carcinogenesis.
Sacral chordoma, an unusual cause of neurogenic bladder: A case report
Authors: Jelleli Nejmeddine , Mnasser Aymen , Sakly Aymen , Slama Meriem , Fouli Sarra , Chouaya Ines , Jellali Bilel , Chouaya Sabrine , Binous Mohamed Yassine
Published: October 2022

Introduction and importance: Sacral chordoma is a rare tumor arising from notochord remnants. Scaral pain is the most common sign. We report the case of a sacral chordoma diagnosed in a urology department. It was a rare cause of erectile dysfunction and it was unusually reaveled by lower urinary tract symptoms (LUTS).
Case presentation: A 67-year-old man had severe dysuria associated with erectile dysfunction. On digital rectal examination, we palpated a mass protruding through the posterior wall of the rectum. The gluteal region is infiltrated by a firm mass. Magnetic resonance imaging (MRI) revealed an osteolytic sacral tumor. A percutaneous biopsy of the tumor was performed. Pathological examination confirmed the diagnosis of chordoma. Patient had palliative radiotherapy. One year after radiotherapy, he had rectal stenosis associated with severe constipation.
Clinical Discussion: Sacral chordoma is a rare malignant tumor. Sacralgia is the most common sign. LUTS and erectile dysfunction were rarely reported in patients affected by this bon tumor. MRI is very suggestive of this pathology. Diagnostic confirmation requires pathological examination. The curative management consists in a large resection of the tumor. For inextricable tumor, palliative radiotherapy can be carried out. The prognosis of chordoma is defined by a high recurrence potential and a low metastatic risk.
Conclusions: Sacral chordoma is a rare bon tumor. It is an unusual cause for LUTS and erectile dysfunction. Complete tumor excision is the only curative treatment. Recurrence after treatment is the main challenge for surgeons.
Prognostic Factors in Patients with Cirrhosis
Authors: Rasheed Modar Haj , Aldouh Maher , Aldeen Mohammad Assd , Ali Ayman
Published: October 2022

Background
Cirrhosis is defined by fibrosis and nodule development in the liver as a result of persistent damage, changing the liver lobule's natural structure. Portal hypertension and hyperdynamic circulation are the key factors that contribute to morbidity and death in cirrhotic individuals. Secondary to cirrhosis and alterations in intrahepatic and systemic vascular structures that lead to the creation of collateral circulation and hyperdynamic circulation, portal hypertension occurs. We want to correlate the most significant cirrhosis prognostic indicators with many of the ocular characteristics we looked at in this study.
Methods
In this cross-sectional study, 319 liver cirrhosis patients who received care at Damascus Hospital between 2015 and 2022 made up the sample.
Results
According to the findings, there is a statistically significant link between prognosis and both the Child Pugh index and patient symptoms (P < 0.05). Regarding the association between prognosis and the patient's vital signs, age, and duration of hospital stay, we were unable to detect any association between these factors.
Conclusion
In order to keep patients with cirrhosis from progressing to later stages of the illness, it is important to evaluate them early. The prognosis of patients was worsened by the more disturbed the Child Pugh criteria were.
Research and Application of Spherical 2R Mechanism based on Conformal Geometric Algebra
Authors: Tong Zhipeng , Yu Gaohong , Liu Jiangang , Zhao Xiong
Published: October 2022

It’s complex to model and solve spherical 2R mechanism on the strength of given positions and attitude angles of endpoints. In this paper, the spherical 2R mechanism is synthetically studied by using conformal geometry algebra, and applied to the design of a seedling pick-up mechanism. Starting from the given key points, the range of the spherical radius where the mechanism moves was studied. The scope was narrowed down as the structural parameters of the mechanism and the interference conditions between the end-effector and the seedling tray. Then, the mathematical model of 2R were established according to the given data. The data of fixed point and rod length were calculated. Furthermore, genetic algorithm was used to select the better fuzzy point with large attitude angle in seedling pushing stage. Finally, a three-dimensional model was established through the parameters of the mechanism and verified by simulation.
Communicative Resources of Public Chambers for the Formation of Public Opinion (on the example of a municipal territory)
Authors: Plotnikova M. A.
Published: October 2022

The current situation in single-industry towns of the Ural Federal District has long suggested the need to build and implement a strategy for sociological support of work and search for public practices of Public Chambers in municipalities. Hence, the purpose of this study was to develop and substantiate a more advanced model of sociological support for the activities of the Public Chamber for the formation of public opinion in the municipal territory, understanding of the authorities of its usefulness, which, as a result, will significantly simplify the procedures for discussing projects for the formation of a comfortable urban environment and other projects to address issues of life support of the municipality by representatives of the socio-territorial community. The novelty of the material is characterized by the use of reflexive practices of the concept of “Good Governance” in building a model of “Effective Governance” for establishing communication processes, cooperation, and involving the population in the process of power management through the Public Chamber at the municipal level. Using the levels of civic engagement established by the citizen engagement standard, the institutional functions of the Public Chamber for the formation of public opinion, its institutional functions are specified as new formats for citizen engagement. An additional constructivist function is proposed: the formation, as a result of the manifestation of civil initiatives, of new social structures from public opinion leaders such as: public councils, city councils, possible communities, territorial self-government bodies subordinate to the Public Chambers of municipalities (as part of them), which is of interest in the study and clarification as another additional institutional function for the formation of public opinion and the involvement of citizens in resolving issues of local governments. On the basis of the experiment conducted on the territory of the municipality (Sverdlovsk region, 2021), the author formulates the new formats for the involvement of the citizens, and develops recommendations for local authorities that would contribute to the establishment of communication processes, cooperation, and further involvement of the citizens in the process of managing power by the population at the municipal level.