bluuebunny/crossref_metadata_2025 huggingface dataset:
Methods of group dynamics as the instrument of the stuff potential development in libraries
Authors: Palkevich O. Ya.
Published: July 2022

The purpose of the article is to present the first results of application of group dynamics methods in the Irkutsk regional library network as a tool for developing libraries personnel potential. In September 2021, a group of specialists of the Irkutsk Regional State Library – representatives of the administration, the scientificmethodological department, the department of cultural programs and the user service department – united into a core group, which started working on methods of group dynamics. The group identified a range of problems of libraries in the Irkutsk region, set goals and tasks for the development of the regional library and the library network of the Irkutsk region, formulated the mission of its activities, created the image of the future of the regional library network, and developed a roadmap for achieving this image of the future. The group expects to work for three years. Having mastered the methods of group dynamics in the ontological school version of “T-System” company and developed shared goals, values and rules, the group members define their functional areas and then form the «group of groups»: specialists from the Irkutsk Regional State Library or from the network of regional libraries and together continue the transformation of the library network. The first results of the group work have been obtained: methods of group dynamics allows to settle to solve complex collective tasks, to create projects of higher quality and degree of elaboration, to hold high-quality operational meetings with a large number of discussed issues. The work on implementing methods of group dynamics into the library network of the Irkutsk region as the instrument of developing the library stuff potential will be continued.
Information support of the topic “Turkic peoples of Siberia”: database and bibliographic index
Authors: Mandrinina L. A. , Rykova V. V. , Busygina T. V. , Balutkina N. A.
Published: July 2022

The article presents the bibliographic database “Türks of Siberia (book editions)”, on which base an eponymous index was formed. The resources were generated within the framework of the Otrar electronic library project curated by the YERTAD Association of History and Culture of the Republic of Turkey. While creating the database and index, the task was to show publications devoted to particular Turkic peoples and their subjects. Thus, the DB documents were indexed by two rubricators: topical and subject, where the subject headings were the Turkic people names including all variants of peoples’ names reflected in publications (above 50 nations). Combining bibliographic resources on Siberian Türks in the form of a database and a printed bibliographic index allows the consumer to view in full the information on the topic accessible to different categories of users. The article analyzes a documentary flow on linguistics of DB “Türks of Siberia (book editions)” with the objectives to characterize publications (dictionaries, monographs, textbooks) on studying the linguistic culture of Siberian Turkic peoples (Yakuts, Tuvans, Altaians, Khakasses, Shors, Siberian Tatars, Dolgans, Kumanlins, Telets, Chelkans, Tofalars of the Chulyms). The analysis showed rather huge volume of book editions on linguistics (over 36% of the total number of publications). Scientific institutes of the relevant profile and universities investigate language and prepare publications on linguistics. The authors state that studying languages of almost all Siberian Turkic peoples is provided with appropriate book editions.
Library and information services: the evolution of approaches to the definition
Authors: Bezmenova A. S.
Published: July 2022

The dynamics of the society and information technologies evolution has a significant impact on all spheres of human life, allowing to develop and expand the range of services provided. This trend is also typical for the library field of activity, where the range of services provided to users is also growing; it actualizes essence and meaning studies of the term “library and information service”. The purpose of the article is to consider the main approaches to the term “library and information service”, taking into account the influence of information technologies and sociocultural factors on the society. To achieve this goal, the analysis of the most famous and frequently encountered 31 concepts has been carried out. The presented definitions are reflected in the current GOSTs for librarianship, current reference and educational literature, as well as in the author’s interpretations of librarians. The analysis has showed that scientists have been revising approaches to the term for many years, but there is still no comprehensive formulation revealing the latest achievements and the essence of library and information services. The terminological analysis has made it possible to identify the genesis of library innovations and to predict the direction of changes in the field of library and information services. It has been concluded that library services are multifaceted actions aimed not only at meeting the user’s needs in various library, information, sociocultural requests in the online and offline space, but also at providing for temporary use the unique equipment for self-realization of one’s creative and educational potential.
The first academic library in Krasnoyarsk (65th anniversary of the library of the Kirensky Institute of Physics of SB RAS)
Authors: Spirina T. V.
Published: July 2022

The publication presents some details to the portrait of the library of the Kirensky Institute of Physics SB RAS, which has its deserved place in the row of libraries, founded in the period of active development of academic science in Siberia, accumulating acceptable practices and creating its own experience.
Comparison of the Short-term Surgical Outcomes in Patients with Closed Traction Injuries to Brachial Plexus
Authors: Ulyanov Vladimir , Bazhanov Sergey P. , Shuvalov Stanislav D. , Korshunova Galina A. , Ostrovskij Vladimir V.
Published: July 2022

As the problem of traction injuries to brachial plexus is a common one and of high socio-economic significance, the analysis of the surgical outcomes in patients with this pathology is significant for neurosurgery, neurology, traumatology-orthopedics, and rehabilitation. The aim of the research is to compare the short-term outcomes of using various surgical methods for managing patients with closed traction injuries of brachial plexus. Material and methods. The research involved 61 patients with closed traction injury of brachial plexus divided into two groups homogeneous in sex, age and severity of their neurological deficit: Group I – 33 patients who underwent microsurgical neurolysis, Group II – 28 patients who underwent microsurgical neurolysis combined with one-level electrostimulation. The dynamic assessment of clinical and functional status of upper limbs was performed using scale methods and electrophysiological monitoring. Results. The research revealed a more evident recovery of the upper limb function in Group II patients suggesting the method of microsurgical neurolysis combined with electrostimulation to be preferable in case of closed traction injuries to brachial plexus. Conclusion. The combination of microsurgical neurolysis with one-level electrostimulation improves the short-term outcomes of surgical treatment in patients with closed traction injuries of brachial plexus due to a sooner decrease in pain in postoperative period, and positive dynamics of clinical and electrophysiological parameters.
Morfologia urbana e crescimento periférico nas cidades médias brasileiras: geotecnologias e inovações metodológicas aplicadas a Montes Claros, Minas Gerais
Authors: Tavares de Paiva Silva Júlio César , Sathler Douglas , Rodrigues Macedo Diego
Published: July 2022

A análise integrada da morfologia urbana e das características funcionais permite uma melhor compreensão da estrutura e da dinâmica intraurbana das cidades médias, indicando uma série de elementos que demonstram associações entre o espaço intraurbano e a intensidade e qualidade do relacionamento de uma determinada centralidade com o seu entorno. Com base no estudo de caso de Montes Claros, Minas Gerais, apresentamos uma proposta metodológica de avaliação de aspectos morfológicos e funcionais de cidades médias, utilizando como principal fonte de dados o Censo Demográfico em conjunto com outras informações geoespaciais livres (i.e., modelo digital de terreno e imagens de satélite). Identificamos a distribuição espacial dos tipos de ocupação, isto é, a densidade de edificações dos tipos domicílio, comércio e serviços e em construção. Ademais, quantificamos e avaliamos as características (renda e estrutura etária) dos vetores de expansão de Monte Claros. Nesse município, identificamos a formação de centralidades intraurbanas menos desenvolvidas em relação a outros polos de desenvolvimento de Minas Gerais (Juiz de Fora, Uberlândia, Pouso Alegre, dentre outros). Na cidade, a concentração das funções em duas centralidades (centro principal e subcentro de maior destaque) amplia a segregação socioespacial, diante da ausência de centralidades importantes nas proximidades das áreas de maior crescimento periférico entre 2000 e 2010.
Two-phase hyperelastic model. “Scalar” case
Authors: Alekseev Mikhail Vladislavovich , Savenkov Evgeny Borisovich
Published: July 2022

The work is devoted to the phenomenological derivation of the multivelocity multifluid model to describe dynamics of the multiphase medium with hyperelastic phase behavior using the Coleman-Noll procedure. The proposed model can be considered as a generalization of the Baer and Nunziato type multiphase models with isotropic stress tensor. The paper presents the well-known particular cases to which the obtained multiphase model can be reduced. The resulting model is completely non-equilibrium, and the joint deformation of the phases is described by a single scalar parameter, which is the volume fraction of the phases.
AMADEOS student school on the design and optimization of interplanetary space missions
Authors: Trofimov Sergey Pavlovich , Korneev Kirill Romanovich , Pyriaev Evgeniy Viktorovich , Zagrebin Ivan Vyacheslavovich , Fattakhov Eldar Maratovich , Morgunov Nikolay Vital'evich , Khurtina Iuliia Olegovna , Lunin Danila Sergeyevich , Yakusheva Diana Evgenievna , Vasiurin Kirill Sergeevich , Tselousova Anastasia Aleksandrovna
Published: July 2022

In September-October of 2021, the first student school on the interplanetary space mission analysis, design and optimization was initiated and hosted by Keldysh Institute of Applied Mathematics. The school objectives and format are presented and discussed in this preprint. The competition problem of designing a science mission to the Neptune system is described. The winner project is published to illustrate the level of the teams.
Tinnitus and the Triple Network Model: A Perspective
Authors: De Ridder Dirk , Vanneste Sven , Song Jae-Jin , Adhia Divya
Published: July 2022

Tinnitus is defined as the conscious awareness of a sound without an identifiable external sound source, and tinnitus disorder as tinnitus with associated suffering. Chronic tinnitus has been anatomically and phenomenologically separated into three pathways: a lateral “sound” pathway, a medial “suffering” pathway, and a descending noise-canceling pathway. Here, the triple network model is proposed as a unifying framework common to neuropsychiatric disorders. It proposes that abnormal interactions among three cardinal networks—the self-representational default mode network, the behavioral relevance-encoding salience network and the goal-oriented central executive network—underlie brain disorders. Tinnitus commonly leads to negative cognitive, emotional, and autonomic responses, phenomenologically expressed as tinnitus-related suffering, processed by the medial pathway. This anatomically overlaps with the salience network, encoding the behavioral relevance of the sound stimulus. Chronic tinnitus can also become associated with the self-representing default mode network and becomes an intrinsic part of the self-percept. This is likely an energy-saving evolutionary adaptation, by detaching tinnitus from sympathetic energy-consuming activity. Eventually, this can lead to functional disability by interfering with the central executive network. In conclusion, these three pathways can be extended to a triple network model explaining all tinnitus-associated comorbidities. This model paves the way for the development of individualized treatment modalities.
A State of the Art Review on the Wellbore Blockage of Condensate Gas Wells: Towards Understanding the Blockage Type, Mechanism, and Treatment
Authors: Shi Bowen , Wang Zhihua , Zhang Zhongwu , Xu Yunfei , Ling Kegang
Published: July 2022

With the development of high-pressure and high-temperature condensate gas wells, the wellbore blockage problems have become increasingly serious. Hence, selecting appropriate treatment technology plays a crucial role in solving the wellbore blockage problems. This study presents a comprehensive literature review on understanding the blockage type, mechanism, and treatment of the high-temperature and high-pressure condensate gas wells. The causes, endangerments, mechanisms, influences, and preventive technologies of the 4 wellbore blockage types are presented. The significant aspects of the treatment technology, such as the principle, type, advantage and disadvantage, adaptability, limitation, and future research direction of the treatment technologies, are thoroughly discussed. The breakthrough solid autogenetic heat treatment technology has been selected to remove hydrate blockage. The present review highlights the current state in the industry, future position, and strategies for the researchers to follow. Finally, the advantages and disadvantages and future research directions of specific treatment technology are presented on the removing effect, cost, and environmental aspects.
Cervical cancer screening programs in Latin America: current recommendations for facing elimination challenges
Authors: Fernández-Deaza Ginna , Caicedo-Martínez Maria , Serrano Beatriz , Roura Esther , Castillo Juan Sebastián , De Sanjosé Silvia , Bruni Laia , Murillo Raúl
Published: July 2022

Objective. To describe current cervical cancer screening program guidelines in Latin America. Materials and methods. We searched official recommendations for the general population and women living with HIV (WLHIV) by reviewing official sources from 19 countries; these data were supplemented with a consultation carried out by the WHO with the Ministries of Health. Results. Screening policies vary significantly in regard to target populations, primary tests, and screening intervals. Sixteen countries have recently updated their recommendations; however, cytology remains the primary screening test for most countries. Eleven countries have introduced HPV tests, and eight countries have implemented screen-and-treat algorithms; only three countries have developed evidence-based guidelines. All countries but Costa Rica have specific recommendations for WLHIV. Conclusions. Although most countries have updated their screening policies, only a few are properly alig­ned with the WHO elimination strategy. Recommendations for WLHIV require better integration with cervical cancer screening programs.
Violencia intrafamiliar, tiempo para una articulación efectiva
Authors: Dávila-Raigoza Angélica María , García-Perdomo Herney Andrés
Published: July 2022

No disponible
Outcomes of neonates born to women with Covid-19
Authors: Castillo-Bejarano José Iván , Siller-Rodríguez Daniel , Cisneros-Saldaña Daniela , Garza-Cantú Jesús María , Garza-Bulnes Raúl , Vera-Delgado Jorge , Ruíz-Rodríguez Claudia , Alanís-Cruz Orlando Sebastián , García-Rodríguez Fernando , Mascareñas-De los Santos Abiel Homero
Published: July 2022

Not available
Prevalence of anti-SARS-CoV-2 antibodies and associated factors in healthcare workers of a Mexican Covid-19 hospital
Authors: Herrera-Ortiz Antonia , Rojas-Delgado Héctor Ugo , García-Cisneros Santa , Xibille-Friedmann Daniel X , Martínez-Barnetche Jesús , Olamendi-Portugal María , González-Sánchez Hilda Minerva , Sánchez-Alemán Miguel Ángel
Published: July 2022

Objective. To determine the prevalence of SARS-CoV-2 antibodies among healthcare workers (HCW) and to identify factors associated with infection. Materials and meth­ods. A cross-sectional study was conducted in a Covid-19 hospital in Morelos, Mexico. Antibodies against SARS-CoV-2 spike and nucleocapsid proteins were detected by ELISA. A bivariate and multivariable Poisson regression model were performed to identify factors associated with infection. Results. Among all participants, 31% had anti-SARS-CoV-2 antibodies, while only 13.1% had reported a history of positive RT-PCR. Individuals who reported cohabiting with someone with Covid-19, and those who had a previous RT-PCR test, were more likely to be seropositive. Laboratory personnel had the lowest seroprevalence (12.0%), while social workers had the highest (35.7%). Conclusions. The results of this study show the seroprevalence of SARS-CoV-2 antibodies among HCW in a hospital in Mexico, and underline the importance of serological tests for a better estimate of prevalence in health systems where only symptomatic cases are recorded.
An Optimal Classifier discovery for diagnosing the account health in financial firms and a study of classifier performance on imbalanced data
Authors: Suguna R. , Subhashini R. , Lakshmanan Ramanathan , S Ananda Kumar , S Stavros N Shiaeles Stavros N Shiaeles , Sangeetha R
Published: July 2022

Customers are the backbone for any financial companies. The behaviour of customer changes over time and they disconnect when the services do not meet their expectations. Earning loyalty of the customer by providing remarkable services and adopting retention strategies are mandatory to run any user centric businesses. In view of the growth perception there is need for company to identify the churn and avoid them in time. The mechanism for churn prediction requires to explore the insight of data. Machine learning algorithms are capable of mining the patterns present in the data and able to discriminate between classes with statistical learning. A Standard bank dataset has been considered for the study and exploratory data analysis performed to understand the nature of the data. Suitable data pre-processing is done and training data split from dataset has been used to build classifier models. The dataset was found to be imbalanced and by adopting appropriate sampling the dataset was balanced. Linear, Non-linear and boosting classifiers were built and their performances on test data are summarized. A comparative study on the classifier performance for both imbalanced as well as balanced dataset was observed and an optimal classifier for diagnosing customer account health has been suggested.
Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients
Authors: Liu Xianyu , Shan Yunhan , Zhao Deze , Cui Weifang , Xie Qun , Jiang Junjie , Peng Wei , Zhang Chunfang , Duan Chaojun
Published: July 2022

Background. Lung Squamous Cell Carcinoma (LUSC) is an aggressive malignancy with limited therapeutic options. The response to immune therapy is a determining factor for the prognosis of LUSC patients. This study aimed to develop a reliable immune-related prognostic signature in LUSC.Methods. We extracted gene expression and clinical data of LUSC from The Cancer Genome Atlas (TCGA). A total of 502 patients enrolled and were divided into respond and non-respond groups by the TIDE algorithm. The CIBERSORT algorithm and the LM22 gene signature were used to analyze the distribution of immune cells in LUSC. Efficacy and response strength of immunotherapy are calculated by the tumor mutation burden (TMB) and ESTIMATE Score. Differentially expressed genes (DEGs) between the two groups were analyzed. The differential expression genes related to overall survival were pointed as hub DEGs, and a prognostic signature was constructed with lasso regression analysis.Results. LUSC patients were divided into responder and non-responder groups based on the response to immunotherapy. The distribution of immune cells was significantly different between the two groups. Forty-four DGEs were considered as overall survival-related genes. A prognostic signature was constructed, consisting of 11 hub-DGEs, including MMP20, C18orf26, CASP14, FAM71E2, OPN4, CGB5, DIRC1, C9orf11, SPATA8, C9orf144B, and ZCCHC5. The signature can accurately distinguish LUSC patients into high and low-risk groups. Moreover, the high-risk group had a shorter survival time than the low-risk group. The area under the ROC curve was 0.67. The multivariate Cox regression showed that the risk score calculated by the constructed signature was an independent prognostic predictor for LUSC patients.Conclusion. In short, we established a novel immune-related prognostic signature in LUCS, which has significant sensitivity and accuracy in predicting the prognosis of patients. Our research can guide the evaluation of the prognosis of LUSC patients in clinical, and the discovered immune-related genes can provide a theoretical basis for the discovery of new therapeutic targets.
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo/YAP pathway
Authors: Wang Lijun , Wang Lihui , Wang Rongli , Xu Ting , Wang Jingyuan , Cui Zhiwei , Cheng Feiyan , Wang Wei , Yang Xinyuan
Published: July 2022

Background: Stem cells have been documented as a new therapeutic method for ovarian injuries such as premature ovarian failure (POF). However, effects of exosomes (Exos) derived from human endometrial stem cells (EnSCs) on diminished ovarian failure remain to be carefully elucidated. Our study aims to investigate the mechanisms of EnSC-Exos in the recovery of the cisplatin-induced granulosa cell injury model in vitro or POF mouses model in vivo and whether the Hippo signal pathway is involved in the regulation. Methods: Exosomes derived from human EnSCs were isolated by ultracentrifugation and identified by electron microscopy and western blot (WB) analysis, stained by PKH26, respectively. The mechanism involving suppression of Hippo signaling pathway and activation of Yes-associated protein (YAP) was investigated for evaluating EnSC-Exos therapeutic effects in the cisplatin-induced granulosa cell injury model in vitro using flow cytometry, WB, qRT-PCR, immunofluorescence and EdU staining. Hematoxylin-eosin staining, ELISA and immunohistochemistry analysis were used for evaluating EnSC-Exos therapeutic effects in POF mouses model.Results: In this study, we established successful construction of the cisplatin-induced granulosa cell injury model and evaluated Hippo signaling pathway activation in cisplatin-damaged granulosa cells (GCs). Furthermore, laser scanning confocal microscope and immunofluorescence demonstrated that EnSC-Exos can be transferred to cisplatin-damaged GCs to decrease apoptosis. In addition, the enhanced expression of YAP at the protein level as well as YAP/TEAD target genes, such as CTGF, ANKRD1 and the increase of YAP into the nucleus in immunofluorescence staining after the addition of EnSC-Exos to cisplatin-damaged GCs confirmed the suppression of Hippo signaling. While in vivo, EnSC-Exos successfully remedied POF in a mouse model. Conclusions: Collectively, our findings suggest that human EnSC-Exos is effective in recovery of ovarian function by chemotherapy-induced POF via activating YAP and inhibiting the Hippo signaling pathway. These findings provide new insights for further understanding of EnSC-Exos in the recovery of ovary function.
Study on the interaction mechanism between Crocus sativus and Fusarium oxysporum based on dual RNA-seq
Authors: Luo Juan , Zhang Aolai , Tan Kaifeng , Yang Shuting , Ma Xiaona , Bai Xiaolin , Hou Yutong , Bai Jie
Published: July 2022

Fusarium oxysporum is a widely distributed soil-borne fungus, which is the most serious pathogen in Crocus sativus production. Due to the lack of resistant cultivars of saffron，and the unclear disease resistance and pathogenic mechanism, there is no really effective control method at present. In this study, the process of F.oxysporum infection of saffron corms and the physiological responses of saffron were analyzed. On this basis, dual RNA-seq was performed on the saffron corms inoculated on the 3th and 6th days of F. oxysporum to analyze the defense-related genes of saffron and the pathogenicity-related genes of F. oxysporum. The results showed that on the third day of infection, it was observed that the hyphae completely entered the corm cells and colonized and spread in the cells; on the sixth day of infection, hyphae have appeared in xylem cells to block vessels. Interacting transcriptome results indicate that in the host saffron, its phenylpropanoid metabolism, plant hormone signal transduction and plant-pathogen interaction pathways were activated during infection process, which were conducive to the enhancement of cell wall, the occurrence of hypersensitivity, and the accumulation of various antibacterial proteins and phytoantitoxins. Meanwhile, in the fungus, the expression levels of cell wall degradationenzyme-related genes, growth and development -related genes and pathogenicity-related genes in F. oxysporum were up-regulated, indicating its strong pathogenicity. The study provides a new insight into the molecular mechanism of the interaction between C. sativus and F. oxysporum, and also provides a theoretical basis for mining saffron disease resistance genes.
Association between Interleukin-8 Polymorphism and Wheezing: A Meta-Analysis
Authors: Zhang Bo , Liu Ying , Qi Wen , Zhou Liting , Ye Lin
Published: July 2022

PurposeA number of studies reported on associations of single nucleotide polymorphisms (SNPs) present in Interleukin-8 with wheezing. The present study was then undertaken to perform a meta-analysis of all the results published to date.MethodsAll studies on the association of IL-8 gene polymorphisms with wheezing published before December 312020 were retrieved from the PubMed, Web of Science, Embase and ScienceDirect databases and Cochrane Library. RevMan 5.0 software was used to perform meta-analysis of the data that fulfilled the criteria for our meta-analysis. The effect size of 3 SNPs on IL-8 gene on wheezing was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).ResultsA total of 6952 subjects (3755 cases and 3197 controls) from 13 studies were genotyped. Meta-analysis suggested the association of rs4073 AA, rs4073 AA + AT, rs2227306 TT, rs2227306 TT + TC, rs2227307 TT with wheezing was 0.90 (95% CI 0.71 ~ 1.15), 0.96 (95% CI 0.76 ~ 1.21), 0.85 (95% CI 0.72 ~ 1.00), 0.88 (95% CI 0.77 ~ 1.01), 0.67 (95% CI 0.32 ~ 1.40). Meta-analysis demonstrated asthma association for rs4073 AA (OR = 0.61, 95% CI 0.44 ~ 0.85, P = 0.004) and rs2227306 TT (OR = 0.54, 95% CI 0.38 ~ 0.78, P = 0.0009).ConclusionThe present meta-analysis suggests that rs4073 AA and rs2227306 TT genotype polymorphisms of IL-8 are associated with decreased risk for asthma.
Tapered PCF Mach-Zehnder interferometer based on Surface Plasmon Resonance (SPR) for estimating concentration Toxic metal ions (Lead)
Authors: Jassam Ghufran Mohammed
Published: July 2022

In this work, Mach-Zehnder interferometer (MZI) based Surface-Plasmon-Resonance (SPR), is created by fusing two regular single-mode fibers with a photonic crystal fiber (PCF) (SMF -PCF-SMF) for estimating the concentration and refractive index of Toxic lead ion. A little part (4cm) of Photonic crystal fiber is manufactured in the middle of the sensor, and then the tapering process is completed, the gold metal is then deposited at a thickness of about (40nm). Toxic lead ion are placed on gold coated core of a Photonic crystal fiber. The calculated the signal to noise ratio, sensitivity, resolution and Figures of merit are approaching SNR is 0.09, S 714 nm/RIU, Resolution is 2.8x10-3and the FOM is5.368 is a chivied.
Convergence of a modification of the Jacobi method particularly indicated on matrices with non-negative coefficients. Version 2
Authors: tagliaferro fulvio
Published: July 2022

The rate of convergence of an iterative method for linear systems analogous to Jacobi's method is tested. The method is particularly suitable for systems with a matrix with non-negative coefficients. An attempt is being made at this point to justify this fact.
Impact of the geometric parameters on the performance of silicon TG SOI N FinFET 5nm
Authors: lazzaz abdelaziz , Bousbahi Khaled , Ghamnia Mustapha
Published: July 2022

Semiconductor device dimensions have been downsized to nanoscale dimensions to upgrade the driving capacity and increasing speed. At the lower technology node, the performance of conventional CMOS circuits degrades because of the short channel effects (SCEs). the researchers expect to identify new solutions for different design issues as a result, the FinFET device has been introduced as an alternative to MOSFET for advanced scalability which allows the use of multi gates in order to dissipate lower power. This paper presents an analysis of TG N SOI (Semiconductor On insulator) FinFET 5 nm using Hafnium Dioxide and the Non-Equilibrium Green Function (NEGF) formalism to study the quantum effect. The different parameters such as leakage current, the ON current, the performance ratio ION/IOFF which are calculated and optimized. The aim and the novelty of this simulation is to present novel geometric parameters that improve the performance of the device, and hence to have optimized CMOS circuits.
Evaluation of the Agro-morphological traits, seed characterization and the genetic diversity of local Rice (Oryza sativa L.) Varieties of Pakistan
Authors: Fazal Urooj , Uddin Israr , Khan Amir Muhammad , Khan Fahim Ullah , Khan Mudassar Nawaz , Iqbal Navid , Ibrahim Muhammad , Bangash Sajid Ali Khan
Published: July 2022

Background: Broad base genetic diversity is essential for a sustainable crop yield to provide tolerance against biotic and abiotic stresses. In Pakistan, rice is ranked second as a staple food and cultivated under different climatic zones. However, very little is known in terms of rice genetic diversity.Methods and results: Present research were performed to evaluate the genetic diversity among 12 local rice varieties by using 5 SSR markers. Furthermore, agro-morphological parameters and seed characterization of these varieties were studied. The highest plant height (204.3 cm) and panicle length (40.1 cm) were observed for Hans-raj, the maximum number of panicles were recorded for dilrosh-97 (47.3). The maximum number of primary and secondary panicle branches were observed in Ratua-81 (51) and super basmati (62), respectively. Super basmati showed highest number of filled grains (264.3) and total number of grains per panicle (315). The minimum days to maturity was recorded for ratua-81 (140 days), and highest 1000 grains weight was recorded for Ksk-133 (27g). The highest concentration of elements, e.g. zinc (Zn) was observed in Ks-282 (44µg/g), Iron (Fe) in hansraj (190.3µg/g), manganese in bamla sufaid (111.3µg/g), copper (Cu) in hansraj (856.3µg/g), lead (Pb) in super basmati (3883.3µg/g), and nickel (Ni) was found in basmati-385 (314.6ug/g). For the genetic diversity analysis, five SSR markers were used and a total of 60 alleles were amplified with 20% polymorphism, RM28130 showed the highest PIC value (0.60). The maximum number (3) of alleles were produced by RM28089. Based on secondary panicle branches and total number of filled grains, Super basmati showed best panicle architecture and grain yield, which can be used in breeding program to develop high yielding aromatic rice genotypes.Conclusions: The highest number of filled grains and total number of grains per panicle were observed in super basmati, which indicated the potential adaptation. Basmati Hansraj, Ks-282, Super basmati and Basmati surkh-161 were found to be highly rich in micronutrients (iron, zinc, copper, lead and manganese). The maximum genetic distance was observed in basmati-2000 and basmati surkh 161 genotypes.
Enhancement in Performance of the PVC / Nanoclay Mixed Matrix Nanofiltration Membrane
Authors: Ferdowsi Amirhoosein , Kikhavani Tavan , Ashrafizadeh S.Nezamoddin
Published: July 2022

Mixed matrix membranes are considered as a novel generation of membranes that have favorable separation and stability properties of inorganic and polymeric membranes at the same time. In this study, the effects of presence of clay nanoparticles (CNs) on the enhancement of properties and performance of PVC nanofiltration membranes were investigated. FTIR, AFM, XRD, EDS, and FESEM analyses were used to evaluate the mixed matrix membranes. Significant improvements in the membrane hydrophilicity, porosity, permeation flux, and rejection were observed by incorporating CNs. The highest rejection of 94.8% was obtained with mixed matrix membranes containing 2 wt% of CNs. The permeation flux of this membrane was enhanced by 75% relative to the neat membrane.
Integrator complex subunit 15 controls mRNA splicing and is critical for eye development
Authors: Azuma Noriyuki , Yokoi Tadashi , Tanaka Taku , Matsuzaka Emiko , Saida Yuki , Nishina Sachiko , Terao Miho , Takada Shuji , Fukami Maki , Okamura Kohji , Maehara Kayoko , Yamasaki Tokiwa , Hirayama Jun , Nishina Hiroshi , Handa Hiroshi , Yamaguchi Yuki
Published: July 2022

The eye and brain are composed of elaborately organized tissues, development of which is supported by spatiotemporally precise expression of a number of transcription factors and developmental regulators. Here we report the molecular and genetic characterization of Integrator complex subunit 15 (INTS15). INTS15 was identified in search for the causative gene(s) for an autosomal-dominant eye disease with variable individual manifestation found in a large pedigree. While homozygous INTS15 knockout mice are embryonic lethal, mutant mice lacking a small C-terminal region of INTS15 show ocular malformations similar to the human patients. INTS15 is highly expressed in the eye and brain during embryogenesis and stably interacts with the Integrator complex to support snRNA 3′ end processing. Its knockdown resulted in missplicing of a large number of genes, probably as a secondary consequence, and substantially affected genes associated with eye and brain development. Moreover, studies using human iPS-derived neural progenitor cells showed that INTS15 is critical for axonal outgrowth in retinal ganglion cells. This study suggests a new link between general transcription machinery and a highly specific hereditary disease.
Circularly Polarized Tunable Graphene-Patch over SiO2 substrate for THz Applications
Authors: Narayaswamy Nagesh Kallollu , Bhosle Manju Ramrao , Penmatsa Krishna Kanth Varma , Dwivedi Ajay Kumar
Published: July 2022

In this communication, a graphene-based radiator is designed and analyzed at THz frequency. A tilted dumbbell-shaped aperture is loaded on a graphene patch for creating degenerated orthogonal mode with 900 phase shift, which in turn produces circularly polarized (CP) waves. Graphene patch is placed over SiO2 substrate. Slot loading in graphene patch shifts the frequency band due to a reduction in effective permittivity. Another important feature of the proposed antenna is to provide a tunable feature in the frequency response and axial ratio by changing the chemical potential. The proposed antenna operates from 5.85 THz to 6.05 THz. 3-dB axial ratio is obtained from 5.85 THz to 5.95 THz. Good value of gain, as well as left-handed circular polarization characteristics, makes the proposed THz antenna in biomedical applications
Anatomical Analysis of Sphenoid Sinus and its Surrounding Structures in Cone-beam Computed Tomography Images: A Retrospective Cross-sectional Study
Authors: Foroozandeh maryam , Salemi fatemeh , khodakarami leyla , alafchi behnaz
Published: July 2022

Background
Anatomical analysis of the sphenoid sinus is important because of its proximity to vital neurovascular structures. The aim of this study is investigating the anatomy of the SS and its surrounding structures in CBCT images.
Methodology:
In this retrospective cross-sectional study, 201 cone-beam computed tomography (CBCT) radiographs were analyzed. The analyzed images included the type of SS, protrusion of ICA and optic nerve and foramen rotundum, vidian canal type, the Onodi cell, pneumatization to surrounding bones, the ostium, the septum. The data were analyzed using chi-square and the t-test in SPSS 24 at a significance level of 0.05.
Results
The tilted septum had the highest frequency (46.3%). Ostium was bilateral in most images (56.2%). The protrusion of the ICA (54.7%) and optic nerve (62.2%) was smooth in most images. Foramen rotundum protrusion and Onodi cell prevalence were 25% and 22.9%, respectively. The postsellar type of sinus had the highest frequency (71.1%). Vidian canal Grade II had the highest frequency (40.3%). Greater wing pneumatization had the highest frequency (51.7%). No statistically significant relationship was found between the optic nerve protrusion and Onodi cell (P-value < 0.05). There was a significant relationship between the pneumatization of the pterygoid process and the protrusion of the vidian canal, and the foramen rotundum protrusion (p-value < 0.001).
Conclusion
CBCT imaging is very effective in the anatomical analysis of the SS and its surrounding structures. The postsellar type had the highest frequency.Vidian canal Grade II had the highest frequency; greater wing pneumatization was observed in more than half of the images; the most common type of septum was tilted; ostium was bilateral in most cases; the protrusion of the ICA and optic nerve was mostly smooth.
CRISPR/Cas9-mediated AtGATA25 mutant represents a novel model for regulating hypocotyl elongation in Arabidopsis thaliana
Authors: Kim Kihwan , Shin Juhyung , Kang Tae-An , Kim Byeonggyu , Kim Won-Chan
Published: July 2022

Background: Plants have evolved while adapting to the ever-changing environment through various morphological changes. The circadian clock is an endogenous oscillator with approximately 24 hours that enables an organism to anticipate and respond to changes in its environment. The circadian clock regulates various physiological processes, such as hypocotyl elongation in Arabidopsis thaliana. Phytochrome interacting factor 4 (PIF4), a member of the bHLH protein, plays a vital hub role in light signaling pathways and temperature-mediated growth response mechanisms. PIF4 is controlled under the circadian clock by interaction with several factors. However, the components regulating PIF4 transcription and activity are not clearly known.Methods and results: Here, we show that the Arabidopsis thaliana GATA25 (AtGATA25) transcription factor plays a fundamental role in promoting hypocotyl elongation by positively regulating the expression of PIF4. It was confirmed to in the loss-of-function mutant of AtGATA25 via CRISPR/Cas9-mediated gene editing inhibits hypocotyl elongation and decrease the expression of PIF4. In contrast, the overexpression of AtGATA25 in transgenic plants showed increased expression of PIF4 and enhanced hypocotyl elongation. To better understand AtGATA25-mediated PIF4 transcriptional regulation, we analyzed the promoter region of the target gene PIF4 and characterized the role of GATA25 through transcriptional activation analysis.Conclusion: our findings provide a new perspective on the adaptive development of plants along with the circadian clock, a critical environmental factor.
Role of Nanotechnology in Microbial mediated Remediation
Authors: CHAURASIA PREETI , Jasuja Nakuleshwar Dut , Kumar Sanjeev
Published: July 2022

Man-made pollution and pollutants are increasing day by day which has prompted alarming health issues and a declining availability of clean drinking water. Xenobiotic compounds from the waste of industries aggregate in agricultural soils and penetrates in the food chain. Thus, imposes a negative influence on the natural ecosystem and eventually impacts on human. The limitations of conventional methods used in remediation to get rid of the contaminants have given rise to trial nanotechnological aids for environmental clean-up by various researchers. The use of nanoparticles produced by microorganisms with the aid of nano biotechnology is known as nano bioremediation. This substitute for developing nanoparticles is an eco-compatible, environment-affable and cost-efficient method to eliminate the contaminants. Nanoparticles have shown their effectiveness over bulk materials as they confer easy handling, large surface area, economic viability, higher reactivity, and hence better performance. Microorganisms like bacteria, fungi, yeast, actinomycetes, and algae are exploited as a “biofactory” for the nanoparticle’s synthesis such as cadmium sulfide iron, silver, gold, platinum, titanium, titanium dioxide, palladium, magnetite, etc for the conversion and detoxification of the contaminants. Microbes have secured remarkable attentiveness as they possess the potency to synthesize nanoparticles in varying sizes, shapes and compositions with distinct physicochemical features for the elimination of heavy metals, organic, inorganic contaminants, organochlorines, dyes in soil and water treatment. Developments withinside the subject of nanoparticle biosynthesis will raise the commercial economic system through producing inexperienced energy. This manuscript emphasizes the importance and mechanism of environmental remediation of pollutants by microbe-driven nanoparticles.
3D Biomimetic Tumor Microenvironment of HCC to Visualize the Intercellular Crosstalk between Hepatocytes, Hepatic stellate cells, and cancer cells
Authors: Liu Chun , Liu Yaolin , Yang Xiaoqian , Jiang Dong , Hu Rongcheng , Huang Fangli , Peng Zhenwei
Published: July 2022

While a significant number of studies have focused on elucidating the functioning mechanisms of the Hepatocellular carcinoma (HCC) microenvironment, the intercellular crosstalk between multiple cells in the tumor microenvironment remains unclear. Here we co-cultured spheroids of HCC cells, hepatic stellate cells (HSCs), and hepatocytes in a biomimetic composite hydrogel to construct a 3D model of the HCC microenvironment in vitro. The model reproduced the major cellular components of early HCC in a biomimetic 3D microenvironment, realizing the visualization of the cellular interplay between cells and the microenvironment. Using this model, we showed the HSCs were activated when co-cultured with HCC cells and deposed collagen to remodel the microenvironment, which in turn triggered higher EMT levels in HCC cells. The hepatocytes also responded to the existence of HCC cells and the activation of HSCs in co-culture, showing the downregulated expression level of ALB, AFP, and HNF4A. This model recapitulated the activation of HSCs in the HCC microenvironment and enabled visualization of multi-cellular interplay in 3D, providing a biomimetic platform to investigate mechanisms of HCC and related hepatic fibrosis.
Ab-Initio Characterization of Iron Embedded Nitrogen Doped Graphene as a Toxic Gas Sensor
Authors: Nosheen Uzma , Abdul Jalil , Ilyas Syed Zafar , Ahmed Sarfraz , Illahi Ahsan , Rafiq Muhammad Aftab
Published: July 2022

Special binding sites in graphene are beneficial for near surface interaction. These binding sites are provided by single atom catalyst results in the modification of electronic characteristics of graphene and its derivatives which largely extend their application as gas sensors. In present work, transition metal atom iron supported on nitrogen doped graphene (FeN/G) was analyzed by density functional theory. The effect of gas adsorption on the structural and electronic properties were investigated with adsorption energy, charge transfer, work function and band structure. The results indicate chemisorption nature of CO, NO and NO2 with strong adsorption energies of -1.641 eV, -2.081 eV and − 1.345 eV. They induced spin polarization when adsorbed on the graphene support which drastically modulate the electronic characteristics of the substrate. While other gas molecules (CO2, H2S and NH3) with adsorption energies of -0.154 eV, -0.371 eV and − 0.46 eV were weakly physisorbed and electron donor in nature. SO2 exhibited weak chemisorption at a value of -0.62 eV. Nitrogen containing gas molecules of NO, NO2 and NH3 showed band gap shortening with increasing conductivity as compared to bare iron embedded graphene supported structure. On the basis of investigation, the structure has potential application for detection of NO and NO2.
YM155 and chrysin cooperatively suppress survivin expression in SMARCB1/INI1-deficient tumor cells
Authors: Yoshino Yuki , Goto Hiroaki , Ito Mieko , Tsurusaki Yoshinori , Takita Junko , Hayashi Yasuhide , Yanagimachi Masakatsu
Published: July 2022

SMARCB1/INI1 deficiency is seen in several malignant tumors including malignant rhabdoid tumor (MRT), a highly aggressive pediatric malignancy. Loss of SMARCB1/INI1 function alters diverse oncogenic cellular signals, making it difficult to discover effective targeting therapy. By utilizing an in vitro drug screening system, effective therapeutic agents against SMARCB1/INI1-deficient tumors were explored in this study.In the in vitro drug sensitivity test, 80 agents with various actions were screened for their cytotoxicity in a panel of five SMARCB1/INI1-deficient tumor cell lines. The combination effect was screened based on the Bliss independent model. The growth inhibitory effect was determined in both the conventional two-dimensional culture and the collagen-embedded three-dimensional culture system. Survivin expression after agent exposure was determined by Western blot analysis.All five cell lines were found to be sensitive to YM155, a selective survivin inhibitor. In the drug combination screening, YM155 showed additive to synergistic effects with various agents including chrysin. Chrysin enhanced YM155-induced apoptosis, but not mitochondrial depolarization upon exposure of SMARCB1/INI1-deficient tumor cells to the two agents for 6 hours. YM155 and chrysin synergistically suppressed survivin expression, especially in TTN45 cells in which such suppression was observed as early as 6 hours after exposure to the two agents.Survivin is suggested to be a therapeutic target in MRT and other SMARCB1/INI1-deficient tumors. Chrysin, a flavone that is widely distributed in plants, cooperatively suppressed survivin expression and enhanced the cytotoxicity of YM155.
DFT Study of Alanine Interactions with Carbon Nanotubes
Authors: LONE BALIRAM
Published: July 2022

The interactions of biomolecules with nanomaterials play crucial role to design new material in wide range of applications for practical use. The physical adsorption mechanism of Alanine (Ala) molecules on surface of pristine semiconducting, zigzag single walled carbon nanotubes (8,0) (SWNTs) were quantum chemically computed by applying density functional theory (DFT). Thermodynamical extracted data indicates favorable binding of L-alanine-SWNT complex system. It depends on orientation of L-alanine molecules i.e., the weak binding is observed. We calculated various parameters including adsorption energy, HOMO-LUMO gap and density of states (DOS) on surface of SWNT (8,0), which absorb the amino acids L-alanine with release of energy owing to its CH3, -COOH and -NH2 functional groups. There are no bonded interactions between Ala-SWNT (8,0) biomolecular complex system. Our results are useful for targeted drug delivery of L-Alanine in biomedical applications, besides to this, the biosensors[1] can be used to check concentration level of alanine in patients to avoid delay in treatment as well.