bluuebunny/crossref_metadata_2025 huggingface dataset:
Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature
Authors: Kang Junlin , Tian Shilai , Zhang Lei , Yang Gang
Published: February 2024

Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.
Risk prediction models for lung cancer in people who have never smoked: a protocol of a systematic review
Authors: Issanov Alpamys , Aravindakshan Atul , Puil Lorri , Tammemägi Martin C. , Lam Stephen , Dummer Trevor J. B.
Published: February 2024

Background

Lung cancer is one of the most commonly diagnosed cancers and the leading cause of cancer-related death worldwide. Although smoking is the primary cause of the cancer, lung cancer is also commonly diagnosed in people who have never smoked. Currently, the proportion of people who have never smoked diagnosed with lung cancer is increasing. Despite this alarming trend, this population is ineligible for lung screening. With the increasing proportion of people who have never smoked among lung cancer cases, there is a pressing need to develop prediction models to identify high-risk people who have never smoked and include them in lung cancer screening programs. Thus, our systematic review is intended to provide a comprehensive summary of the evidence on existing risk prediction models for lung cancer in people who have never smoked.

Methods

Electronic searches will be conducted in MEDLINE (Ovid), Embase (Ovid), Web of Science Core Collection (Clarivate Analytics), Scopus, and Europe PMC and Open-Access Theses and Dissertations databases. Two reviewers will independently perform title and abstract screening, full-text review, and data extraction using the Covidence review platform. Data extraction will be performed based on the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS). The risk of bias will be evaluated independently by two reviewers using the Prediction model Risk-of-Bias Assessment Tool (PROBAST) tool. If a sufficient number of studies are identified to have externally validated the same prediction model, we will combine model performance measures to evaluate the model’s average predictive accuracy (e.g., calibration, discrimination) across diverse settings and populations and explore sources of heterogeneity.

Discussion

The results of the review will identify risk prediction models for lung cancer in people who have never smoked. These will be useful for researchers planning to develop novel prediction models, and for clinical practitioners and policy makers seeking guidance for clinical decision-making and the formulation of future lung cancer screening strategies for people who have never smoked.

Systematic review registration

This protocol has been registered in PROSPERO under the registration number CRD42023483824.
Monocyte lymphocyte ratio, IL 6, and their association with increased carotid intima-media thickness as simple predictive markers for nephropathy in Egyptian diabetic patients
Authors: Ibrahim Heba Mahmoud Mohamed , Bahgat Heba Morad , Sharshar Deena Ahmed , Ramzy Tarek Abdel Azim
Published: February 2024

Background

Inflammation is a cardinal mechanism of diabetic kidney disease (DKD). Interleukin-6 (IL6) is a reliable indicator that plays a role in the progression of DKD. Monocyte-to-lymphocyte ratio (MLR) is also implicated in this inflammatory process. The progression of DKD is associated with increased carotid intima-media thickness (CIMT), which is an independent predictor of atherosclerosis.

Aim

The role of IL6 and MLR ratio influencing the progression of DKD was assessed using the urinary albumin creatinine ratio (UACR) and glomerular filtration rate (GFR). Moreover, their contribution to increasing CIMT in DKD was assessed.

Methods

An observational prospective study was conducted on ninety diabetic patients presented to the Internal Medicine Clinic at Kasr AlAiny. The subjects were classified into three groups, thirty patients for each, according to UACR: with normoalbuminuria, microalbuminuria, and macroalbuminuria. A history and clinical assessment, CBC, MLR, HbA1c, lipid profile, IL6, creatinine, and eGFR were carried out. Furthermore, CIMT was measured using Doppler ultrasound.

Results

The results showed that IL6 and MLR were significantly higher in the macroalbuminuria group compared to the other two groups with p < 0.001, suggesting that their higher level could predict the progression of DKD. According to the ROC curve, the cutoff values of MLR and IL6 were 0.3425 and 7 pg/ml, respectively. Moreover, CIMT increased significantly in micro and macroalbuminuric patients with p > 0.001. IL6 and MLR were positively correlated with CIMT in micro and macroalbuminuric patients.

Conclusion

Both MLR and IL-6, as simple biomarkers associated with increased CIMT, play an important role in predicting the nephropathy of DKD patients.
Empowering scientific progress: the vital role of open-access, peer-reviewed methods and protocols
Authors: Cilibrasi Chiara
Published: February 2024

In the ever-evolving landscape of scientific research, the importance of detailed, accessible methods and step-by-step reusable protocols cannot be overstated. In alignment with this BMC Methods, is dedicated to facilitating the dissemination of open-access, peer-reviewed novel experimental procedures, techniques, and methodologies to promote reproducibility, transparency, and the advancement of scientific methods in the natural sciences.
Accelerated Early Childhood Growth Is Associated With the Development of Earlier Adrenarche and Puberty
Authors: Liimatta Jani , Jääskeläinen Jarmo , Mäntyselkä Aino , Häkkinen Merja R , Auriola Seppo , Voutilainen Raimo , Flück Christa E , Lakka Timo A
Published: February 2024

Context

Small birth size and increased postnatal growth have been associated with earlier timing of adrenarche and puberty, but it is not well known whether these factors alone or together lead to earlier maturation.

Objective

This work aimed to search for different growth trajectories using a clustering approach to analyze the effects of birth size and postnatal growth on adrenarchal and pubertal development.

Methods

Altogether 351 children (48% girls) were examined prospectively at ages 6 to 9 and 9 to 11 years. Birth and early-growth data were collected retrospectively. Main outcome measures included clinical signs of adrenarche and puberty, and serum androgen concentrations (dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone).

Results

We detected 4 clusters with different birth sizes and postnatal growth trajectories: 1) children with average birth size and increased postnatal growth (AI), 2) children with small birth size and increased postnatal growth (SI), 3) children with average birth size and postnatal growth (AA), and 4) children with small birth size and average postnatal growth (SA). Thelarche at age 9 to 11 was most common and serum androgens at ages 6 to 9 and 9 to 11 years were highest in girls belonging to the AI and SI groups. Similar patterns in the onset of puberty and in androgen levels were not seen in the SA group.

Conclusion

Increased early growth and weight gain predict higher serum androgen concentrations and earlier onset of puberty in girls. Adrenarche and puberty do not appear to be shifted earlier in children with small birth size who do not have catch-up growth.
A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans
Authors: Bai Xiaofei , Smith Harold E. , Romero Luis O. , Bell Briar , Vásquez Valeria , Golden Andy
Published: February 2024

The mechanosensitive PIEZO channel family has been linked to over 26 disorders and diseases. Although progress has been made in understanding these channels at the structural and functional levels, the underlying mechanisms of PIEZO-associated diseases remain elusive. In this study, we engineered four PIEZO-based disease models using CRISPR/Cas9 gene editing. We performed an unbiased chemical mutagen-based genetic suppressor screen to identify putative suppressors of a conserved gain-of-function variant pezo-1[R2405P] that in human PIEZO2 causes distal arthrogryposis type 5 (DA5; p. R2718P). Electrophysiological analyses indicate that pezo-1(R2405P) is a gain-of-function allele. Using genomic mapping and whole-genome sequencing approaches, we identified a candidate suppressor allele in the C. elegans gene gex-3. This gene is an ortholog of human NCKAP1 (NCK-associated protein 1), a subunit of the Wiskott-Aldrich syndrome protein (WASP)-verprolin homologous protein (WAVE/SCAR) complex, which regulates F-actin polymerization. Depletion of gex-3 by RNAi, or with the suppressor allele gex-3(av259[L353F]), significantly increased brood size and ovulation rate, as well as alleviating the crushed oocyte phenotype of the pezo-1(R2405P) mutant. Expression of GEX-3 in the soma is required to rescue the brood size defects in pezo-1(R2405P) animals. Actin organization and orientation were disrupted and distorted in the pezo-1 mutants. Mutation of gex-3(L353F) partially alleviated these defects. The identification of gex-3 as a suppressor of the pathogenic variant pezo-1(R2405P) suggests that the PIEZO coordinates with the cytoskeleton regulator to maintain the F-actin network and provides insight into the molecular mechanisms of DA5 and other PIEZO-associated diseases.
[Δημοσθένους] 58 'ενδειξις κατά Θεοκρίνου'
Authors: Χουστουλάκη Γεωργία
Published: February 2024

Ο Κατὰ Θεοκρίνου (or. 58) είναι λόγος κατηγορίας που εκφωνήθηκε περί το 340 π.Χ. σε υπόθεση ἐνδείξεως, δηλαδή σε δίκη δημόσιου ενδιαφέροντος που έχει κινηθεί εναντίον προσώπoυ που ασκεί κάποιο δικαίωμα το οποίο έχει στερηθεί διά νόμου. Παρότι ο λόγος προσγράφεται στον Δημοσθένη, η πατρότητά του έχει αμφισβητηθεί ήδη από την αρχαιότητα και πλέον αποτελεί κοινή πεποίθηση ότι ο Αθηναίος ρήτορας δεν μπορεί να είναι ο συγγραφέας του, γιατί μεταξύ άλλων αντιμετωπίζεται με εχθρότητα. Η παρούσα διατριβή αποτελείται από τρία μέρη. Το πρώτο μέρος περιλαμβάνει μια εκτενή εισαγωγή στην οποία συζητούνται η υπόθεση, η χρονολόγηση, το νομικό πλαίσιο, η ταυτότητα και η σκιαγράφηση των διαδίκων, η πατρότητα, το ύφος και άλλα κεντρικά ζητήματα του λόγου. Έπειτα ακολουθεί το αρχαίο κείμενο που βασίζεται κυρίως στην πρόσφατη έκδοση του Dilts. Παραπλεύρως του κειμένου υπάρχει μετάφραση, με βασική μέριμνα την απόδοση του αρχαιοελληνικού κειμένου σε σύγχρονο νεοελληνικό λόγο που διασώζει, στο μέτρο του εφικτού, το γράμμα και το πνεύμα του πρωτοτύπου. Το τρίτο μέρος αποτελείται από το ερμηνευτικό υπόμνημα στο οποίο σχολιάζονται κατά λήμμα ποικίλα ζητήματα (γλώσσας και ύφους, ρητορικής, δικαίου, ιδεολογίας, πολιτικής κ.α.), με στόχο την κατά το δυνατόν πληρέστερη και εγκυρότερη ενημέρωση του αναγνώστη.
Diogenes syndrome - causes and treatment of pathological hoarding and self neglect
Authors: Czarnota-Kuczyńska Julia , Cichoń Katarzyna , Chyćko Małgorzata , Trąbka Natalia , Demidowicz Gabriela , Younes Martyna , Lasota Nina , Wiśniewski Wojciech , Lambach Maciej , Kowalczyk Klaudia
Published: February 2024

Introduction

Diogenes syndrome is a behavioral disorder typically described in physically neglected people living in extreme poverty, unsanitary conditions and self-imposed isolation, who often refuse outside help and tend to accumulate unusual objects. This syndrome is gaining increasing attention in the world of neurology and psychiatry.

 

The aim of the study

To summarize current knowledge on the causes of Diogenes syndrome, its characteristics and treatment.

 

Material and methods

The search of the Pubmed and Google Scholar database was carried out using keywords, in order to find the latest publications.

 

Summary

Diogenes syndrome is a complex disease that will affect an increasing number of elderly people as the population ages. There is a lack of extensive research to create clear diagnostic criteria, classification and treatment for Diogenes syndrome. The creation of a disease entity would enable earlier diagnosis and help patients.
Assessment of the Relationship Between Genetic Determinants of Migraine and Thyroid Dysfunction - Review
Authors: Kwiecień Justyna , Getka Beata , Łata Michał , Przyborowska Kinga , Wiejak Katarzyna , Rukat Mateusz
Published: February 2024

Introduction and objective: The purpose of this paper is a systematic review of articles and research in the context of the relationship between genetic determinants of migraine and thyroid dysfunction.
Materials and methods: A non-systematic review of the scientific literature was carried out according to the following keywords:  PubMed was searched and 76 articles published up to 2023 were analyzed.
Description of the state of knowledge: Epidemiological studies confirm the co-occurrence of migraine and thyroid dysfunction, especially hypothyroidism, which are considered to be diseases with a strong genetic background. Thyroid function parameters such as TSH and fT4 are susceptible to genetic influences. However, there is a lack of consistent interpretation of the observational results, which highlights the need for further research. Analysis of gene overlaps and links between headache and thyroid function, based on GWAS data, could shed light on the complex genetic interactions underlying this association.
Summary: The genetic associations revealed in the study enhance our comprehension of the intricate relationship between migraine and thyroid dysfunction. These findings not only offer the prospect of developing biomarkers for identifying migraine patients who might benefit from thyroid hormone therapy but also underscore the promising potential of future genetic studies in providing biological insights to advance clinical decision-making in understanding and addressing these interconnected phenomena.
Italica. Espacios de culto en el anfiteatro
Authors: Beltrán Fortes José , Rodríguez Hidalgo José Manuel
Published: February 2024

El núcleo de este estudio arqueológico lo constituye un análisis arquitectónico y la identificación exacta de los espacios de culto, la catalogación y análisis de los exvotos. Se pretende por tanto, proporcionar al especialista el máximo de datos arqueológicos, así como dar a conocer, al público en general, la importancia de los cultos que se realizaron en el anfiteatro italicense.
Staging Masculinity in Ancestral and Colonial Legacies in Sembene Ousmane's Cinematic Debut during Senegal's Independence Interlude (1960-1965).
Authors: Bayo Saiba
Published: February 2024

This article studies the debut of Sembene Ousmane’s cinematic narrative during the early years of Senegal’s independence. Sembene was a renowned anti-colonial Senegalese writer who shifted to filmmaking during the “independence interlude”, from 1960 to 1965, with his first film Borom Sarret (1963), he became a pioneer of African cinema. Sembene’s revolutionary filmmaking and radical artistic project catapulted him to the realm of world cinema. Drawing on postcolonial film criticism, this article focuses on two of Sembene’s pioneering films: Borom Sarret and Niaye. I argue that he strategically crafted these films to genuinely contribute to the collective effort of postcolonial reconstruction. I start with a brief review of Sembene’s literary works during the independence interlude to understand how this period influenced his artistic perspective and cinematic narrative regarding gender. I then delve into an analysis of masculinity and colonial legacy in Borom Sarret, and finally focus on Niaye to explore how the filmaker depicts collective memory and patriarchal dynamics in a pseudo-feudal society in transition from colonialism to independence, from tradition to modernity. This article contributes to a better understanding of how Sembene approached social transformation, navigated (post)colonial power structures shaped by colonial and ancestral legacies, and established himself as an iconoclastic artist
O canto das vozes esquecidas: : as tradições orais no cinema de Assia Djebar.
Authors: Gama de Lima Morgana , Maia Guilherme
Published: February 2024

Embora o envolvimento de mulheres nas revoluções africanas, especialmente na Argélia, seja um fato reconhecido no curso da história (Bedjaoui, 2020), ao observar filmes produzidos no contexto africano que buscam a reconstituição de tais acontecimentos, é possível perceber ausências quanto ao modo como essa participação feminina foi representada. Logo, no presente trabalho propomos uma abordagem em torno dos filmes La Nouba des femmes du Mont Chenoua (1975- 1977) e La Zerda, les chants de l’oubli (1978-1982), realizados pela cineasta argelina Assia Djebar (1936-2015), partindo da hipótese de que tais produções além de permitirem outros modos de representação das mulheres na revolução argelina, também convidam a uma outra compreensão da narrativa histórica ao se apropriar de elementos das tradições orais como recurso retórico da narrativa fílmica (Soulez, 2011). Um processo que tem início na valorização de contos e cantos como fontes inspiradoras na composição da narrativa fílmica e que, por meio da análise, oferece possíveis contribuições sobre a forma como pensamos a oralidade nos cinemas africanos, de modo geral, e de modo específico, sobre o potencial da voz (Chion, 1992; Châteauvert, 1996), especialmente feminina, em acionar memórias, por meio da narrativa fílmica em favor da revisão de fatos históricos.
GUERRA DE PAPEL EN EL MAR CARIBE. LA CIRCULACIÓN DE LA INFORMACIÓN DURANTE LOS PROCESOS BÉLICOS MARÍTIMOS DEL SIGLO XVIII.
Authors: Moreno Cabanillas Rocío
Published: February 2024

En el siglo XVIII, durante el contexto de rivalidades imperiales, la circulación de información se convirtió en un elemento crucial para el éxito en la guerra y la política. En este artículo se argumenta que la adaptabilidad de los sistemas de comunicación postal desempeñó un papel esencial en la toma de decisiones militares y políticas en el espacio caribeño, caracterizado por su dinamismo y su conectividad.
EL DIARIO DE ANDRÉS DE URDANETA (1524-1536). SECUESTRO Y RECUPERACIÓN.
Authors: Romero Tallafigo Manuel
Published: February 2024

Andrés de Urdaneta fue despojado por la Corona de Portugal de su Diario de la expedición castellana a las Molucas (1525-1536). En esta centuria, los frailes de la Orden de San Agustín recuperaron una copia para argumentar sus Crónicas y Centurias, en respuesta católica a la Historia Ecclesiastica de los luteranos Centuriadores de Magdeburgo. En el siglo XIX, del “Colegio de Cuenca” de Salamanca pasó a la Biblioteca Nacional de Madrid. La trayectoria del manuscrito revela prácticas de escritura, de transmisión por copias y de usos de la información
EL ARCHIVO GENERAL DE PLEITOS FENECIDOS DE LA REAL CHANCILLERÍA DE GRANADA EN EL SIGLO XVIII: HISTORIA DE UN FRACASO.
Authors: de la Guardia y López Luis Díaz
Published: February 2024

El presente trabajo aborda el proyecto que en la segunda mitad del siglo XVIII buscó dotar a la Real Chancillería de Granada de un Archivo General de Pleitos fenecidos y retardados, a imitación del existente en Valladolid. Un proyecto fracasado por las defectuosas propuestas, su coste y la oposición de los escribanos de Cámara granadinos.
EL EXPEDIENTE DE INDULTO DE RAMÓN LLANOS BAEZA (PUERTO RICO, 1893): INJERENCIAS DEL PODER EJECUTIVO EN EL JUDICIAL Y SUS REMINISCENCIAS DEL ANTIGUO RÉGIMEN.
Authors: Torres Aguilar Manuel
Published: February 2024

En este trabajo se introducen algunas de las regulaciones que sobre el indulto estaban vigentes en el siglo XIX, como reminiscencias del Antiguo Régimen, para llamar la atención de que solamente hasta 1870 no se aprobó la regulación de la institución del indulto, que sirvió de marco legal para tramitar el indulto de un alcalde de Puerto Rico, que mereció cierto trato de favor por las autoridades gubernamentales a pesar de los graves delitos electorales cometidos.
THE INFLUENCE OF CARIBBEAN COLONIES ON EUROPEAN WOMENS FASHION AT THE END OF THE XVIII CENTURY AND BEGINNINGS OF XIX.
Authors: Malagon-Mancebo Massiel
Published: February 2024

Neoclassical fashion defined its diaphanous look by seeking to revive the style of the ancient Roman civilization, and the marble statues of ancient Greece; further influenced by the excavation of Pompeii in 1738 and its archeological developments in 1748. The attitudes towards voluminous and pompous fashions had changed, however the acceptance of the new modern and much more revealing silhouette did not occur without challenges. For neoclassical fashion to be accepted it needed a foundation to make it plausible, and it needed a pioneer to wear and deem it ‘appropriate’. This study builds a comprehensive analysis of some of the relationships France, England and other European countries built with their colonies in terms of textile manufacturing, imports and exports, and most importantly cultural appropriation. This study seeks to analyze how those colonies gave them new fashion perspectives, to develop the neoclassical fashions, we recognize from that period. In addition, this study will analyze the powerful influence of Josephine Bonaparte and other important female figures from neoclassical France, in perpetuating and expanding the use of these fabrics and styles; most importantly Josephine’s Caribbean background and her possible preference for lighter fabrics due to her birth on the island of Martinique, and how that influenced her sophisticated and cosmopolitan approach to fashion.
MUJERES COMERCIANTES EN EL NORTE DEL VIRREINATO PERUANO (1780-1821).
Authors: Rosas Navarro Ruth Magali
Published: February 2024

Si bien se ha publicado abundantemente acerca del comercio liderado por los varones, es también necesario prestar atención al esfuerzo de las mujeres en su contribución a la economía familiar, solas o al lado de esposos u otros parientes. Este artículo identificará tanto a mujeres de la elite social como a las de clases bajas para verificar su aporte al comercio interno del norte del virreinato peruano.
DESIGN MODELING USING DEM DATA AND APPLICATION OF GEOTECHNICAL STUDY ON CLAY 134 MINE PT SOLUSI BANGUN INDONESIA TBK, TUBAN PLANT
Authors: Assagaf Umar Raihan , Charea Wanda Nurlaily
Published: February 2024

PT Solusi Bangun Indonesia Tbk is one of of the companies engaged in the building materials solutions industry in Indonesia, with an annual cement production capacity of 14,8 million tons and operates four plant namely in Lhoknga, Narogong, Cilacap, and one of them is located in Tuban, East Java precisely in Mekarwang, Tambakboyo, Tuban, East Java. The mining operation can proceed if it fulfils the requirements of the Work Plan and Budget (RKAB) in accordance with the Minister of Energy and Mineral Resources Decree No. 1806 K/30/MEM/2018. The mine planning is important aspect in planning mine design as the production objective. mine planning is the most crucial aspect in the mine design planning as a reference to achieve production targets. The raw material targets production in 2024 for clay is 2 million tons and the calculated tonnage obtained is 1.95 million tons. The opening of a new area is carried out in two blocks, namely E3 and D3, which are divided into three sections of new open-pit mining. To provide practical, fast, and efficient mapping, mapping is carried out using UAV (Unmanned Aerial Vehicle) which produces topographic and orthophoto maps. To understand the relationship of slope stress-strain, slope stability is identified using a geotechnical study with the simplified bishop method. The results show that the north-south cut has a safety factor of 1.882, while the east-west cut has a safety factor of 1.845 and categorized as safe because it complies with the Minister of Energy and Mineral Resources Decree No. 1827 K30 MEM 2018, which states that a Safety Factor (FS) value is >1.5. From this research, the researcher hopes for improvements in the quality of aerial photo data to produce accurate and optimal slope stability results.
DIGITAL MANUFACTURING MODEL FOR REMOTELY OPERATED VEHICLE (ROV) IN INDONESIA: A CONCEPT STUDY
Authors: Artaraharja Yoseph Daniswara , Widjaja Sjarief , Hermawan Yuda Apri
Published: February 2024

Industrial revolution 4.0 era represents a paradigm shift in manufacturing and technology, which is characterized by an integrated and interconnected system to support the operation of an industry. Many countries contributed to this era, including Indonesia. As a maritime country, maritime-related products have the potential to be offered. Remotely operated vehicles (ROV) is a form of digitalization product that is frequently used to support the operation of the maritime industry. Therefore, ROV is manufactured locally to provide easier access to industries demanding ROV. Digital manufacturing for ROV can bring further contributions towards industrial revolution 4.0, which involves the usage of digital technologies such as computer-aided design and manufacturing (CAD/CAM), internet of things (IoT), artificial intelligence (AI), and robotics to create an integrated manufacturing system. Furthermore, digital manufacturing information system provides real-time information during the manufacturing process. According to this study, digital manufacturing can significantly improve the efficiency and integration in manufacturing the ROV.
INVESTIGATING THE IMPACT OF INNOVATION TECHNOLOGIES IN LOGISTICS (CROSSING TRANSPORTATION MODEL: CASE STUDY OF THE LANGARA - KENDARI ROUTE)
Authors: Siddiq Muhammad Sya’ban Shibawaihi , Hardiyanti Fitri , Buana I Gusti Ngurah Sumanta
Published: February 2024

Konawe Islands is a regency in the Southeast Sulawesi Province. This area heavily relies on Kendari City, the provincial capital, to support daily necessities, recreational activities, and higher education pursuits for the people of Konawe Islands. Wooden boats and ferries serve as the primary means of transportation for the locals. However, during harsh weather, only ferries is operational. Yet, there have been loading violations on ferries, increasing the risk to maritime safety. This research aims to formulate ways to address loading issues on ro-ro ferries along the Langara-Kendari route, ensuring compliance with laws and facilitating smooth cargo distribution. The distribution system is structured based on the method persona user and empathy mapping. Research findings indicate that distribution service users require a freight forwarder for large-scale cargo and consolidation for smaller-scale loads. Therefore, the author recommends the use of applications like Uber, Grab, and Uber to resolve this issue.
REDISCOVER PARADISE: ELEVATING BALI’S MARINE TOURISM THROUGH SUSTAINABLE SOLID WASTE MANAGEMENT (SSWM)
Authors: Ardiyanto Feri , Prakasa Gilang , Achmadi Tri
Published: February 2024

As a global tourist destination, Bali’s marine ecosystem holds significant value for the leisure industry. However, along with the enormous growth of the industry, the island also faces an imminent waste crisis. As of 2022, 1,085,507 metric tonnes of waste are produced by the island, which 18% of it or 190,726 metric tonnes of waste left unmanaged. Coupled with monsoon and wet season weather that delivers trash ashore, effective waste management holds a pivotal role to preserve the marine ecosystem of the island and its tourism industry. By conducting a qualitative descriptive method, this research proposes sustainable solid waste management (SSWM) as an attempt to combat the waste crisis on the island. This research aims to depict the feasibility – cost, and benefit – of implementing the SSWM. The findings of this research conclude that the implementation of SSWM will benefit the marine ecosystem and further sustain tourism in Bali.
All about… clay
Authors: Rawstrone Annette
Published: February 2024

What are the particular benefits of providing clay as a resource, and how are some settings introducing clay-making skills? Annette Rawstrone finds out
Market view: SELL AND TELL
Authors: Turner Leah
Published: February 2024

Leah Turner, co-founder of Owen Froebel, which offers day nursery brokerage, valuations and sales, on whether providers should tell their landlord they are selling.
Radiological outcomes following surgical fixation with wires versus moulded cast for patients with a dorsally displaced fracture of the distal radius: a radiographic analysis from the DRAFFT2 trial
Authors: Plant Caroline E. , Ooms Alexander , Cook Jonathan A. , Costa Matthew L.
Published: February 2024

Aims

The primary aim of this study was to report the radiological outcomes of patients with a dorsally displaced distal radius fracture who were randomized to a moulded cast or surgical fixation with wires following manipulation and closed reduction of their fracture. The secondary aim was to correlate radiological outcomes with patient-reported outcome measures (PROMs) in the year following injury.

Methods

Participants were recruited as part of DRAFFT2, a UK multicentre clinical trial. Participants were aged 16 years or over with a dorsally displaced distal radius fracture, and were eligible for the trial if they needed a manipulation of their fracture, as recommended by their treating surgeon. Participants were randomly allocated on a 1:1 ratio to moulded cast or Kirschner wires after manipulation of the fracture in the operating theatre. Standard posteroanterior and lateral radiographs were performed in the radiology department of participating centres at the time of the patient’s initial assessment in the emergency department and six weeks postoperatively. Intraoperative fluoroscopic images taken at the time of fracture reduction were also assessed.

Results

Patients treated with surgical fixation with wires had less dorsal angulation of the radius versus those treated in a moulded cast at six weeks after manipulation of the fracture; the mean difference of -4.13° was statistically significant (95% confidence interval 5.82 to -2.45). There was no evidence of a difference in radial shortening. However, there was no correlation between these radiological measurements and PROMs at any timepoint in the 12 months post-injury.

Conclusion

For patients with a dorsally displaced distal radius fracture treated with a closed manipulation, surgical fixation with wires leads to less dorsal angulation on radiographs at six weeks compared with patients treated in a moulded plaster cast alone. However, the difference in dorsal angulation was small and did not correlate with patient-reported pain and function.

Cite this article: Bone Jt Open 2024;5(2):132–138.
A Multi-Path QKD Algorithm with Multiple Segments
Authors: Liu Cheng , Che Xuanxuan , Xie Jianshe , Dong Yumin
Published: February 2024

Quantum Key Distribution (QKD) provides unconditional peer-to-peer security based on the principles of quantum physics. By utilizing relay nodes, the security of QKD can be extended over longer distances. However, the introduction of relay nodes brings both security and communication success rates issues. To tackle those issues we propose an enhanced multi-path scheme. The key features of our proposal are as follows: 1. By taking the reliability of relay nodes as one of the algorithm inputs,making the scheme more suitable for partially trusted QKD (PTQKD) networks. 2. By using Multi-Segment Multi-Path approach increases the difficulty for attackers to obtain complete key information and improves the security of PTQKD. 3. The adaptive routing algorithm generates a sufficient number of diverse paths based on node contribution rate, key freshness, and reliability. We conducted a theoretical analysis of the algorithm,and simulation results on PTQKD demonstrate that our method outperforms traditional QKD methods in terms of security and transmission success rate. This advancement has the potential to enhance the adoption of QKD networks.
An Analysis of the Mean Chart Under OC Function for Correlated Data
Authors: Khanday Manzoor A. , Pandey Shiv Shankar , Rawat Akansha , Sowjanya Chukka
Published: February 2024

In this paper, we determine and illustrate the effects of correlation between the observations on the operating characteristics curve, Type-I error and Average Run length. In addition, for different correlated coefficient the control limits have been developed. To study the effect of correlated observations the OC curves, Type-I error, ARL and factor A have been worked out using various equation and values are given in Tables 1 to 4. To give a visual comparison of OC function and ARL, curves have been drawn in Figures 1 to 6. It is found that correlation between observations seriously affected the OC, Type-I error, ARL and factor A for the mean chart when standards are known. When the center line and control limits are based on the large value. Thus, it will be healthy contribution in manufacturing process which tracks important product characteristics in industry.
Science Fiction's Facial Optics
Authors: Cameron Allan
Published: February 2024

abstract: In science fiction films involving space travel, the face is often linked aesthetically and conceptually not only with the flat surface of the screen interface but also the spherical environments of the helmet, the spacecraft, and the planetary atmosphere. I explore the relations between eye, face, and screen in Stanley Kubrick's 2001 and its successors, showing how they use facial-optical motifs to mediate encounters between human subjectivity and unfathomable otherness. Ultimately, investigating the ethical dimensions of space exploration cinema's aesthetics of roundness, I argue that recent films display a turning inward and a contraction of both ethical and ontological spheres.
Una Antígona para tiempos de supervivencia: Lo heroico y lo sucio en Antígona del dramaturgo cubano Yerandy Fleites
Authors: Rojo Roseli
Published: February 2024

Abstract: This essay analyzes Antígona (2008) by Yerandy Fleites to show how the author tackles the current Cuban political situation by rewriting the Sophoclean tragedy. Fleites adjusts the Greek myth to the Cuban context by means of parody and an intertextual dialogue with both Jean Anouilh's Antigone (1944) and Peruvian poet José Watanabe's Antígona (2000). The study then unpacks the idea of dirtiness and Fleites' depiction of the female heroine to demonstrate how the dramatist proposes hybris as the main psychological driver behind the Cuban Antígona (and that, to an extent, of the generation she represents) to suggest possible avenues for sociopolitical change. At the same time, this study considers the interpretations of Fleites' Antígona that Cuban directors Pedro Franco and Julio César Ramírez respectively brought to the stage in 2013 and 2020. Ramírez's reading in particular provides an understanding of Antígona in the context of the protests that occurred on November 27, 2020, when intellectuals, writers, and artists demanded that the Cuban Ministry of Culture recognize their rights and their freedom as citizens.
Actitudes políticas: Jaime Kogan y el Equipo Teatro Payró (1967-1980)
Authors: Schcolnicov Eugenio
Published: February 2024

Abstract: This study analyzes the trajectory and stage productions developed by the Argentine theatre director Jaime Kogan between 1967 and 1980. A unique example of the dynamics that directors assumed in the late sixties, the first phase in the production of Kogan and the Equipo Teatro Payró (ETP) took place in a context of enormous political, social, and cultural turbulence. Beyond the alternation between constitutional governments and authoritarian regimes, the period in question includes diverse phenomena that revolve around the same historical process, which is characterized by increasing state violence. In this context, we observe how the transformations in the Kogan's directorial work reveal diverse modes of "micro-political" intervention.
Geometric lightguide for near-eye light field displays
Authors: Chen Shan-Ling , Fu Li-Wei , Huang Jiun-Woei , Shih Kuang-Tsu , Chen Homer H.
Published: February 2024

Most near-eye displays with one fixed focal plane suffer from the vergence–accommodation conflict and cause visual discomfort to users. In contrast, light field displays can provide natural and comfortable 3D visual sensation to users without the conflict. This paper presents a near-eye light field display consisting of a geometric lightguide and a light field generator, along with a collimator to ensure the light rays propagating in the lightguide are collimated. Unlike most lightguides, which reduce thickness by employing total internal reflection that can easily generate stray light, our lightguide directly propagates light rays without total internal reflection. The partially reflective mirrors of the lightguide expand the exit pupil to achieve an eyebox of 13mm(horizontal)×6.5mm(vertical) with an eye relief of 18 mm. The collimator and the light field generator, both having effective focal lengths different in the horizontal and vertical directions, are designed to provide a 40-deg diagonal field of view. The working range of the light field generator, which is 30 cm to infinity, is verified qualitatively and quantitatively by experiments. We optimize the illuminance uniformity and analyze the illuminance variation across the eyebox. Further, we minimize the ghost artifact (referring to the split-up of light fields replicated by the partially reflective mirrors) by orienting the partially reflective mirrors at slightly different angles to enhance the image quality for short-range applications such as medical surgery.
Theory and experiment of transient two-wave mixing in Yb-doped single-frequency fiber amplifiers induced by frequency modulation
Authors: Hauge Jakob M. , Pedersen Jens E. , Bondu Magalie , Papior Sidsel R. , Lægsgaard Jesper
Published: February 2024

This paper presents a theoretical and experimental characterization of an instability phenomenon observed in single-frequency fiber amplifiers when the frequency of the seed laser is modulated. The instability manifests itself as fluctuating elastic back-reflections that occur only when the frequency is decreasing with time. The theory is a generalization of a coupled-mode model developed for a single-frequency fiber amplifier back-seeded with a constant frequency shift relative to the main signal. It can explain most observed features of the experiments in a qualitative and semi-quantitative way. Open questions and directions for further developments are also discussed.
HoloSR: End-to-End 3D Hologram Super-Resolution with Deep Neural Network
Authors: Kim Duksu , No You chan , Lee Jaehong , Yeom Han-Ju , Kwon Sung Min
Published: February 2024

In holography, the resolution of the hologram significantly impacts both display size and angle-of-view, yet achieving high-resolution holograms presents formidable challenges, whether in capturing real-world holograms or in the computational demands of Computer-Generated Holography.
To overcome this challenge, we introduce HoloSR, an innovative hologram super-resolution network powered by deep learning.
Our encoder-decoder architecture, featuring a novel up-sampling block in the decoder, is adaptable to diverse backbone networks.
Employing two critical loss functions, data fidelity and perceptual loss, we guide HoloSR to attain pixel-wise accuracy and perceptual quality.
Rigorous evaluations, using the MIT-CGH-4K dataset, demonstrate HoloSR's consistent superiority over conventional interpolation methods and a prior GAN-based approach.
Particularly, in conjunction with the SwinIR encoder, HoloSR achieves a remarkable 8.46% PSNR enhancement and a 9.30% SSIM increase compared to the previous GAN-based method.
Also, we found that our HoloSR shows more stable reconstruction quality across varying focal distances.
These results demonstrate the robustness and effectiveness of our HoloSR in the context of hologram super-resolution.
Coping and risk perception during the COVID-19 pandemic in type 2 diabetes: Does it influence metabolic control?
Authors: Alcántara-Garcés María Teresa , Rodríguez-Ramírez Alejandra Monserrat , García-Ulloa Ana Cristina , García-Alanis Mario , Martínez-Reyes Gabriela Nazareth , Del Moral Vidal Lupita Paola , Arizmendi-Rodríguez Rodrigo Eduardo , Hernández-Jiménez Sergio , Almeda-Valdes Paloma
Published: February 2024

Diabetes and poor glycemic control are significant predictors of severity and death in the COVID-19 disease. The perception of this risk in individuals with type 2 diabetes (T2D) could modify coping styles, leading to behaviors associated with better self-care and metabolic control. Theoretically, active coping is associated with better glycemic control in patients with T2D. Nonetheless, information during extreme risk like the COVID-19 pandemic is still limited. Our objective was to evaluate the association between coping styles and risk perception in the COVID-19 pandemic and the change in metabolic parameters. This is a prospective study that included individuals with T2D treated in a tertiary care center during the COVID-19 outbreak who returned to follow-up one year later. We assessed coping styles and risk perception with the Extreme Risk Coping Scale and the risk perception questionnaire. Clinical characteristics and metabolic parameters were registered in both visits. Groups were compared using Kruskal Wallis tests, and changes in metabolic parameters were assessed with Wilcoxon rank sum tests. Our sample included 177 participants at baseline, and 118 concluded the study. Passive coping was more frequent in women. Low-risk perception was associated with higher age, lower psychiatric comorbidities, and lower frequency of psychiatric treatment compared with other risk perception groups. Patients with active coping plus high-risk perception did not have a change in metabolic parameters at follow-up, whereas patients with other coping styles and lower risk perception had an increase in total cholesterol, LDL-cholesterol, and triglycerides. There were no differences by coping group or by risk perception in glycemic control.
Access to and utilization of COVID-19 antigen rapid diagnostic tests (Ag-RDTs) among people living with HIV (PLWH): A mixed methods study from Cambodia
Authors: Seang Kennarey , Vogt Florian , Ky Sovathana , Ouk Vichea , Kaldor John , Vallely Andrew , Saphonn Vonthanak
Published: February 2024

Several COVID-19 antigen rapid diagnostic tests have been approved in Cambodia, but no evidence exists about the access to and utilization of these tests. This limits public health interventions to increase testing, especially among vulnerable populations such as people living with HIV (PLWH). We conducted a mixed method study among PLWH in Phnom Penh, Cambodia, between July and August 2022 to understand their current Ag-RDT access and utilization levels, as well as key barriers and drivers. We undertook a cross-sectional survey and focus group discussions among 280 and 10 PLWH, respectively, from five HIV treatment centres using a probability-proportional-to-size and simple random sampling approach. Access was defined as having received a COVID-19 Ag-RDT within the six months and utilization as having administered a COVID-19 Ag-RDT, either to oneself or to others, within the 12 months prior to the study. We calculated means, standard deviations and proportions for continuous and categorical variables, using a linear regression model with random effects to account for clustering. Additionally, we fitted a logistic model with random effects to assess factors associated with Ag-RDT access. For the qualitative data, we used thematic analyses to identify barriers/enablers of Ag-RDT access and utilization. About 35% (n = 101) of PLWH reported having had access to an Ag-RDT test in the past six months. About 11% (n = 32) of the study participants administered the Ag-RDT to themselves, 4% (n = 10) to others and 9% (n = 24) have done both, in the past 12 months. Age and education appeared to be associated with Ag-RDT access in the logistic models. Price and advice from pharmacists were commonly reported to be the main selection criteria for the brand of Ag-RDT chosen. Ag-RDTs are an important diagnostic tool for COVID-19 among PLWH in Cambodia, but familiarity of use and price could hinder better uptake, access and utilization.
Slope stability assessment in the seismically and landslide-prone road segment of Gerese to Belta, Rift Valley, Ethiopia
Authors: Gebreyohannes Daniel , Getahun Ephrem , Jothimani Muralitharan
Published: February 2024

Slope instability on several sections of the Gerese-Belta route in Southern Ethiopia poses a major risk to infrastructure and safety. This research was aimed at evaluating certain areas of the road susceptible to slope instability. Through intensive fieldwork including geological analysis, surveys, and testing, three crucial slope portions were determined. Both limit equilibrium and finite element calculations demonstrated that these sections are problematic under different circumstances. The slope modification analysis shows that the safety factor increases as bench widths and the number of benches increase. In the slope section D1S3, this factor reached 1.222 when two benches measuring 5 meters in width were used on slide 2D. This initially showed an unstable safety factor of 0.26. Three benches of the same width were used under slide 2D. This resulted in a safety factor of 1.219. At the slope section (D1S2), flattening of the slope angle from initial 45⁰ to 35⁰, 28⁰, 25⁰ and 18⁰ increases the factor of safety of the slope from initial 0.284 to 0.77, 0.89, 1.022, and 1.151 respectively under slide 2D analysis. At the slope section (D2S1), flattening the slope angle from initial 46⁰ to 35⁰, 25⁰, 23⁰, and 20⁰ increases the safety factor from initial 0.412 to 0.684, 0.920, 1.02, and 1.315 respectively. Based on the analysis of the study results, it can be concluded that the identified slope sections are susceptible to failure under actual field scenarios, depending on the conditions under which they are predicted to occur. According to this study, the Benching method is an economical method for mitigating soil slopes, as a result of which it was recommended to be used.
Biological Grounding - Real or Imagined
Authors: Brell Edward
Published: February 2024

This article explores the practice of biological grounding (earthing), examining its historicalroots, potential health benefits, and underlying scientific principles. We delved into the roleof the Earth as a natural conductor and the impact of static electricity buildup on the humanbody. Additionally, we reviewed safety considerations, the therapeutic potential of air ions,and the limitations of current research.