bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances and challenges in friction pendulum bearings for seismic isolation systems
Authors: Xu Gang , Zhang Rui-Jun , Liu Yang , Zhang Heng-Yuan
Published: September 2024

Friction pendulum bearings (FPBs) have emerged as critical structural isolation devices in the field of earthquake engineering. Extensive research and development efforts have led to the exploration and refinement of these bearings, resulting in the creation of various models with unique structural configurations and superior mechanical properties. This paper offers an in-depth review of the friction materials employed in FPBs, alongside an analysis of the mechanical performance and advancements in research regarding single-pendulum, double-pendulum, multiple-pendulum, and other types of friction bearings. Characterized by their low sensitivity and high stability, these bearings are adept at resisting seismic forces, thus providing dependable isolation protection for structures. This review also includes a succinct examination of the seismic performance and engineering applications of these isolation structures. With robust self-centering capabilities, excellent isolation, and energy dissipation mechanisms, FPBs are capable of quickly resuming normal operations post-seismic events. This reduces structural damage and maintenance expenses, significantly improving the seismic resilience of structures. Moreover, the paper outlines the current challenges in the research and development of FPBs and suggests future research directions, including optimizing friction materials, enhancing the design and performance of isolation structures, and improving the seismic performance and engineering application efficiency of FPBs. By identifying underexplored areas and synthesizing findings differently, this review provides a comprehensive and novel perspective that advances the field of earthquake engineering.
Positive assessments, monitoring of activities, and dementia
Authors: Lindholm Camilla
Published: September 2024

This article studies the use of positive assessments in interaction in Swedish residential care in Finland. The data consisted of four video recordings of baking activities involving professional caregivers and residents with dementia. The method used was conversation analysis. In these activities, caregivers used positive assessments to facilitate the residents’ performance of the task, either by providing them with the resources needed to perform the task or by performing things for the residents. Assessments were used to encourage the residents in attempting to perform the task, making progress in the task, and achieving autonomous activity in the task. The study demonstrated how residents’ reduced functional capacity makes also minor success worth praising, without an undertone of infantilization.
Impact through engagement? A critical self-reflection on the engaged journalism exchange
Authors: Nelson Jacob L , Wenzel Andrea , Crittenden Letrell
Published: September 2024

Journalism studies scholars have increasingly focused on finding ways to improve the profession and practice they have dedicated their academic careers to better understanding. This critical self-reflection reviews the ways that we have attempted to make our own academic work impactful on journalistic practice. We discuss the challenges, opportunities, successes, and failures of our efforts to both increase the impact of our academic research among journalism professionals, as well as to build better connections with journalists and publics so that we can better inform our research questions and priorities. Our efforts have been difficult to maintain, and their impact has been all but impossible to assess. Our experiences suggest that journalists rarely have the time or resources to listen and act on assessments from academics, and academics rarely have the time, resources, incentives, or patience to find the best paths to sharing what they learn in ways that may lead to change in journalism practices'. In light of these circumstances, we argue that the questions and obstacles journalism scholars face when it comes to improving the impact of their work among media practitioners and community members eerily mirrors the questions and obstacles journalists face when it comes to improving the impact of their work among the public. We conclude by calling for more humility, honesty, and help when it comes to efforts to bridge the gap between journalism studies and practice.
Disseminating archaeological heritage knowledge for development in Africa with special reference to Zimbabwe
Authors: Shenjere-Nyabezi Plan , Pwiti Gilbert , Sagiya Munyaradzi Elton
Published: September 2024

In recent years, culture has gained recognition as a vital element in sustainable development efforts, both globally through the Sustainable Development Goals (SDGs) and in Africa through the African Union’s Vision 2063. However, there remains a significant gap between the scientific community and local communities in terms of understanding and benefiting from archaeological heritage resources. This article draws on a research project conducted in north-western Zimbabwe to explore strategies for effectively engaging communities and empowering them with archaeological knowledge that is traditionally confined to academic circles. In doing so, the discussion draws attention to the need for the adoption of more inclusive approaches to the utilisation of archaeological heritage knowledge for community and national development.
Simple or complex statistical models: Non-traditional regression models with intuitive interpretations
Authors: Heller Gillian Z.
Published: September 2024

The evolution of statistical modelling has historically been constrained by the practical limitations of computation; early statistical modelling favoured models which could feasibly be estimated. As increased mathematical complexity often implies more intricate computation, statistical models have grown both mathematically and computationally more complex. However, paradoxically, sometimes conceptually simpler models present more computational challenges than complex ones, and these have historically been neglected. In the case of binary responses, logistic regression models are the gold standard; covariates are modelled additively on the log-odds scale. In the case of time-to-event responses, the Cox proportional hazards regression model has additivity on the log-hazard rate scale. Both of these methods are computationally convenient, and yet the scales on which covariates are modelled are far from intuitive. We demonstrate the use of alternative models which are computationally more complex, yet feasible, but in which modelling is on a more interpretable scale. In the case of binary responses, a more intuitive alternative is log-binomial regression, in which modelling is on the log-relative risk scale. In the case of time-to-event responses, distributional regression enables modelling on the time scale. While logistic regression and proportional hazards regression qualitatively both deliver the same conclusions as the alternative models, log-binomial and distributional regression provide more interpretable coefficients, which are readily estimated.
A comparison of data visualization tools: A case study in health-related research
Authors: Huang Hongtai , Ravi Sreedevi , Warrington Timothy , Cui Howe , Wang Carlson , McCreary Mark , Lauffer Benjamin , Lu Christina
Published: September 2024

Data visualization tools are important tools for making health decisions based on large amounts of data. However, very few comparisons of data visualization tools have been done in the context of health-related research. This paper compares commonly available visualization tools from the perspective of a dashboard developer in the context of scientific health research using real-world data and to provide general suggestions for dashboard developers’ future visualization efforts in health-related scientific discoveries. We evaluated four commonly available visualization tools (Tableau, Spotfire, PowerBI, and R Shiny). Each tool was evaluated on visualization outcomes (comparing the generated outputs of tables, scatterplots, correlation plots, treemaps, heatmaps, and geographic maps), usability, Cloud compatibility, analytic integration, and a few other factors. All tools generated comparable visualization outcomes in our tests and were equally usable with the exception of R Shiny which is not recommended for users with limited coding experience. Every tool except R Shiny supports connections to PostgreSQL, gSheets, and Athena without additional configurations. All tools support integration with R and Python; however, PowerBI requires some additional configuration. Every tool is capable of data pre-processing and supports data transformation, null detection and outlier detection. Each tool has its own unique advantages and limitations.
Alfred Labinjoh: Edinburgh doctor, Nigerian Pan-Africanist
Authors: Dee Henry
Published: September 2024

Standing at an imposing 6”2, Dr Alfred Labinjoh was a man of considerable stature in Edinburgh – physically, socially and politically – between the 1920s and 1950s. Born in Lagos, Nigeria, he studied medicine in Edinburgh during the early 1920s and subsequently lived in the city until 1957, working as a popular family doctor. By the 1940s, he ran surgeries in Fountainbridge, Pilton and Newlandrig, as well as the Carnegie Nursing Home at 29 Morningside Road. A prominent freemason, philanthropist, and baritone singer, he was also politically active during the 1920s and 1930s, working with the local Edinburgh African Association to raise money for the Red Cross mission to Ethiopia after fascist Italy’s invasion. Although monetary donations and military volunteers from Scotland to Republican Spain are well known, there were also important earlier precedents set by West African students and graduates in Edinburgh in support of Ethiopian resistance fighters which helped galvanise a new form of popular politics in explicit opposition to colonialism and fascism, at home and abroad.
The Try Guys: Making Their Brand Through Direct Address and Cancellation With Feelings
Authors: White Michele
Published: September 2024

The Try Guys’ “what happened” video, which appears on their YouTube channel, narrates their cancellation of colleague Ned Fulmer because of an extra-marital relationship with an employee. Some literature suggests that cancel culture offers disempowered individuals and groups methods of identifying and correcting hateful practices. However, I employ the humanities practice of close reading to demonstrate how emotional cancel practices can elide intolerant systems and sustain norms. I analyze The Try Guys’ content, reportage about the group, and YouTube. As I argue, The Try Guys’ claims about enacting an ethical cancellation displace their reliance on “humorously” sexualizing women’s bodies and mocking femininity in videos about incongruously wearing women’s clothing. I also elaborate on direct address literature as a method of articulating cancel culture’s “direct addresses with feelings,” how The Try Guys use the cancellation to render the brand and connect with fans, and how my analysis contributes to related scholarship.
“Fundamentalist, Mentally Unstable, Male”: A Gendered Analysis of Fear of Terrorism and Crime in Canada
Authors: Corradi Andrea , Egan Kasey
Published: September 2024

Despite the infrequent nature of terrorism in Canada, multiple high-profile extremist incidents have specifically targeted women including the 2018 Toronto van attack. Using a mixed-methods approach informed by constructivist grounded theory, we examine fear and perception of victimization risk of terrorism in Canada in 262 individuals from a gendered perspective, contrasting it with similar measures for crime, finding that women both significantly fear and perceive a higher likelihood of terrorist victimization than men. An examination of cognitive schemas of terrorism revealed divergent patterns by gender, demonstrating that women were also significantly less likely to associate mental illness with terrorism.
Arthrodesis as Salvage for Failed Metacarpophalangeal Arthroplasty
Authors: Rode Matthew M. , Wu Kitty Y. , Welling Benjamin D. , Rizzo Marco
Published: September 2024

Background:

Surgical management of failed metacarpophalangeal (MCP) arthroplasties includes revision arthroplasty and arthrodesis. The purpose of this study was to review the indications and outcomes of arthrodesis as a salvage procedure for failed MCP arthroplasties.

Methods:

This was a retrospective cohort study of all patients undergoing salvage MCP arthrodesis at a single institution from 1990 to 2020. Patient charts were reviewed for patient demographics, indication for salvage, surgical technique, revision rate, and time to radiographic union. Patient-reported outcomes, including the Michigan Hand Outcomes Questionnaire and an MCP-specific questionnaire detailing pain, functional, appearance, and patient satisfaction, were also collected.

Results:

Eleven digits in 9 patients (6 women, 3 men, median age of 66) with median 36-month follow-up were included. The majority (91%) of patients also had concomitant soft tissue deformities, including joint contractures, extension lag, and collateral ligament insufficiency. The overall revision rate following arthrodesis was 45% with 3 digits requiring one revision each, and 2 digits undergoing 3 revisions. The overall union rate was 91% with median time to union of 4 months from most recent arthrodesis. Patient-reported outcomes obtained from 4 patients demonstrated improvements in pain and function.

Conclusion:

Despite a high revision rate of 45%, salvage MCP arthrodesis following arthroplasty has a high eventual union rate of 91% and is associated with improved pain and function based on 4 patients’ experiences. Arthrodesis as a salvage procedure for failed MCP arthroplasties should be considered in patients with persistent joint instability and functionally limiting soft tissue deformities.
Individual Joint Distractions Using Ilizarov Mini-Fixator Device for Chronic Simultaneous Dislocation of the Distal and Proximal Interphalangeal Joints in the Same Finger
Authors: Usami Satoshi , Sonoki Kentaro , Kawahara Sanshiro
Published: September 2024

Simultaneous dislocation of the distal and proximal interphalangeal joints is an uncommon injury. Treating chronic cases proves challenging due to severe contractures affecting both joints and surrounding soft tissues. Here, we report an unusual chronic contracture case in a 46-year-old man who suffered a dorsal dislocation of the distal and proximal interphalangeal joints of the little finger. The patient underwent primary joint distraction followed by open reduction, leading to stable radiographic restoration and a functional range of motion in the affected finger 6 months postoperatively. Joint distraction was a reliable approach for the treatment of chronic joint dislocation with severe soft tissue contracture, especially for multiple joint contractures. In addition, the Ilizarov mini-fixator device was effective in enabling individualized traction on both the distal and proximal interphalangeal joints.
Radiographic predictors of neurologic outcomes in patients with basilar artery occlusion: A single-center experience
Authors: Goldman Daryl , Al-Kawaz Mais , Reddi Preethi , Mehta Amol , Belani Puneet , Shafizadeh Milad , Matsoukas Stavrous , Kellner Christopher P , Mocco J , Fifi Johanna T , Majidi Shahram
Published: September 2024

Background

Randomized controlled trials indicate functional and mortality benefits in endovascular therapy for basilar artery occlusion (BAO). However, these studies only include patients who meet specific prognostic scores. This study investigates radiographic predictors of posterior circulation territory infarcts that may predict neurologic outcome at 90-day post-intervention.

Methods

This is a retrospective cohort study of a prospectively maintained thrombectomy database of all patients who underwent mechanical thrombectomy for BAO. Baseline demographics, comorbidities, baseline functional status (mRS), and severity of presenting neurologic deficits (NIHSS) were collected. Pc-ASPECTS, posterior circulation collateral score (PCCS), and basilar artery on computed tomography angiography (BATMAN) measured radiographic characteristics. Core infarct territory was identified. Primary outcomes were good neurologic outcome (mRS 0–3) and poor neurologic outcome (mRS 4–6) at 90-day post-thrombectomy. 90-day mortality was a secondary outcome.

Results

About 21.5% of patients achieved a good neurologic outcome. About 32.3% of patients were deceased at 90 days. Receiver operating characteristic analysis shows PCCS collateral scores (AUC = 0.74, SE = 0.03, CI = 0.62–0.74) and BATMAN (AUC = 0.72, SE = 0.04, CI = 0.35–0.49) have potential to differentiate between those with good neurologic outcome from those with poor neurologic outcome. Although there was no statistically significant difference in AUC between the three curves, pc-ASPECTS score trended toward being weaker predictor of neurologic outcome (AUC = 0.49, SE = 0.04, CI = 0.35–0.49). There were significant associations between 90-day poor neurologic outcome and established infarcts within the pons ( p = 0.01), left cerebellum ( p = 0.01), and left occipital lobe ( p = 0.03) on pre-thrombectomy CT.

Conclusion

Low BATMAN and PCCS collateral scores can be predictors of poor neurologic outcomes at 90-day post-thrombectomy for BAO while pc-ASPECTS score may be a weaker predictor of outcome.
Venous sinus stenosis intracranial hypertension, rethinking idiopathic intracranial hypertension in the setting of venous sinus stenosis: A call for new nomenclature and diagnostic precision
Authors: Abou-Mrad Tatiana , Alaraj Ali
Published: September 2024

Idiopathic intracranial hypertension (IIH) is traditionally characterized by elevated intracranial pressure without an identifiable cause, primarily affecting obese women. However, recent evidence suggests that venous sinus stenosis may play a significant role in the pathophysiology of IIH, challenging its designation as “idiopathic.” This editorial discusses the limitations of the current nomenclatures and diagnostic criteria, highlighting the importance of routine venography in detecting venous sinus abnormalities, irrespective of a patient's demographic profile. We propose a new nomenclature of this subset of patients to venous sinus stenosis intracranial hypertension in order to promote more accurate diagnosis and targeted treatment, including potential endovascular interventions.
Estimating Breakfast Characteristics Using Continuous Glucose Monitoring and Machine Learning in Adults With or at Risk of Type 2 Diabetes
Authors: Pai Ryan , Barua Souptik , Kim Bo Sung , McDonald Maya , Wierzchowska-McNew Raven A. , Pai Amruta , Deutz Nicolaas E. P. , Kerr David , Sabharwal Ashutosh
Published: September 2024

Background:

Continuous glucose monitoring (CGM) systems allow detailed assessment of postprandial glucose responses (PPGR), offering new insights into food choices’ impact on dysglycemia. However, current approaches to analyze PPGR using a CGM require manual meal logging, limiting the scalability of CGM-driven applications like personalized nutrition and at-home diabetes risk assessment.

Objective:

We propose a machine learning (ML) framework to automatically identify and characterize breakfast-related PPGRs from CGM profiles in adults at risk of or living with noninsulin-treated type 2 diabetes (T2D).

Methods:

Our PPGR estimation framework uses a random forest ML algorithm trained on 15 adults without diabetes who wore a CGM for up to four weeks. The algorithm performance was evaluated on a held-out subset of the participants’ CGM data as well as on an external validation data set of 36 individuals at risk for or with noninsulin-treated T2D.

Results:

Our algorithm’s estimations of breakfast PPGRs displayed no statistically significant differences to annotated PPGRs, in terms of incremental area under the curve and glucose rise ( P > .05 for both data sets), while a small difference in prebreakfast glucose was found in the nondiabetes data set ( P = .005) but not in the validation T2D data set ( P = .18).

Conclusions:

We designed an ML framework to automatically estimate the timing of meal events from CGM data in individuals without diabetes and in individuals at risk or with T2D. This could provide a more scalable approach for analyzing postprandial glycemia, increasing the feasibility of CGM-based precision nutrition and diabetes risk assessment applications.
Angelica sinensis Polysaccharide Suppresses Pyroptosis in Myocardial Ischemia/Reperfusion Injury via the FN1/NF-κB/NLRP3 Pathway
Authors: Niu Xiaowei , Zhang Wen Jun , Zhao Fei , Zhang Jingjing , Hu Shuwen , Bai Xue , Zhang Zheng , Bai Ming
Published: September 2024

Background

Pyroptosis, a form of inflammatory programmed cell death, has recently emerged as a pivotal factor in the pathogenesis of myocardial ischemia/reperfusion (MI/R) injury. Despite its significance, effective therapeutic strategies targeting MI/R-induced pyroptosis remain elusive in current clinical practice. Previous studies have demonstrated the promising anti-inflammatory effects of Angelica sinensis polysaccharide (ASP) in the context of certain inflammatory disorders.

Objectives

We aimed to investigate the effects of ASP on pyroptosis in MI/R injury and elucidate the potential molecular mechanisms by combining transcriptomic analysis with complementary in vivo and in vitro experiments.

Materials and methods

H9c2 cells were used to establish a hypoxia/reoxygenation (H/R) model, and MI/R injury was induced in rats by ligating and releasing the left anterior coronary artery. Myocardial tissue samples were harvested for transcriptomic sequencing and bioinformatic analyses. Cardioprotective effects were evaluated through electrocardiography, echocardiography, and histological examination. Enzyme-linked immunosorbent assay (ELISA) was employed to quantify levels of inflammatory mediators. Biochemical assays were conducted to assess myocardial injury biomarkers and Caspase-1 activity. Western blotting was performed to analyze the protein expression levels of Fibronectin 1 (FN1), Nuclear factor kappa B (NF-κB) p65, phosphorylated NF-κB p65 (p-NF-κB p65), Nod-like receptor protein 3 (NLRP3), and Gasdermin-D (GSDMD).

Results

Pretreatment with ASP conferred potent cardioprotective effects in a rat model of MI/R injury, as evidenced by significant attenuation of infarct size, myocardial enzyme levels, and ST-segment elevation on electrocardiography, alongside notable improvements in cardiac function. Transcriptomic profiling unveiled that differentially expressed genes modulated by ASP treatment were predominantly implicated in the pyroptosis-elicited inflammatory response. Concordantly, both in vivo and in vitro experiments substantiated that ASP treatment effectively attenuated MI/R-induced pyroptosis, as manifested by diminished levels of pyroptosis-related indicators, encompassing the proportion of TUNEL-positive cells, Caspase-1 activation, GSDMD cleavage, and the liberation of pro-inflammatory cytokines. Further mechanistic investigations revealed ASP inhibition of the FN1/NF-κB/NLRP3 signaling pathway.

Conclusions

Our investigation, leveraging system-level transcriptomic profiling, demonstrates that ASP confers cardioprotective effects against MI/R injury through the suppression of cardiomyocyte pyroptosis, culminating from downregulation of the FN1/NF-κB/NLRP3 pathway.
Imaging and Surgical Procedures After Surface-Related Collegiate Football Injuries on Artificial Turf Versus Natural Grass: Prevalence and Trends Over 15 Seasons
Authors: Meyers Michael C. , Sterling James C. , Robinson Shad K.
Published: September 2024

Background:

Few longitudinal studies exist comparing medical procedures after football injuries on artificial and natural grass surfaces.

Purpose/Hypothesis:

The purpose of this study was to specifically compare imaging and surgical procedures after surface-related collegiate football injuries on artificial turf versus natural grass. It was hypothesized that there would be no difference in the incidence of imaging and surgical procedures, combined medical procedures, or combined substantial and severe injuries over time between these surfaces.

Study Design:

Cohort study; Level of evidence, 2.

Methods:

A total of 39 universities across all Football Bowl Subdivision conferences were evaluated over 15 seasons (2006-2020). Playing surfaces evaluated were either a heavyweight artificial turf infill system (≥9.0 lb infill/ft2) or natural grass. Outcomes of interest included medical procedures across injury category, primary injury type, injury location, and specific procedures. Data involved multivariate analyses of variance (MANOVA) and Wilks λ criteria using general linear model procedures and were expressed as medical procedure incidence rates (IRs) per 10-game season.

Results:

Overall, 2224 games were documented: 1106 (49.7%) on artificial turf and 1118 (50.3%) on natural grass. Of the 9137 total injuries reported, 4010 (44%) were surface-related cases. MANOVA indicated significant main effects between surfaces according to imaging procedure ( F2,1738 = 4.718; P = .009), surgical procedure ( F1,539 = 5.974; P = .003), and medical diagnosis ( F2,456 = 2.643; P = .040). Post hoc analyses indicated significantly lower ( P < .05) incidences on artificial turf versus natural grass, respectively, for the following outcomes: imaging procedures ordered after player-to-surface impact trauma (IR [95% CI], 1.5 [1.3-1.8] vs 2.1 [1.9-2.4]), shoe-to-surface trauma during physical contact (4.4 [4.1-4.7] vs 5.2 [4.9-5.5]), foot injuries (0.6 [0.5-0.7] vs 1.1 [0.9-1.2]), ligament sprains/tears (4.6 [4.3-4.9] vs 5.3 [5.0-5.6]), muscle strains/tears (0.2 [0.2-0.3] vs 0.7 [0.6-0.9]), surgeries performed after shoe-to-surface trauma during physical contact (1.1 [0.9-1.3] vs 1.6 [1.4-1.8]), lower body surgeries (1.8 [1.6-2.0] vs 2.3 [2.1-2.6]), and surgeries involving ligament tears (1.0 [0.9-1.2] vs 1.5 [1.3-1.7]), as well as fewer diagnoses of syndesmosis sprains/tears (0.7 [0.5-0.8] vs 1.0 [0.8-1.2]) and Lisfranc trauma (0.3 [0.2-0.4] vs 0.5 [0.4-0.7]). Trends over the 15 seasons indicated a significant rise in combined medical procedures ( P = .005) and combined substantial and severe injuries ( P = .0007) irrespective of surface.

Conclusion:

Results indicated that collegiate football competition on heavyweight artificial turf resulted in lower incidences of imaging and surgical procedures and medical diagnoses compared with natural grass.
The Differences in Content of Health Care Plans of Medical and Nursing Students in Interprofessional and Uniprofessional Education
Authors: Teuwen Carolyn , Scheffer Hanke , Sekmen-Algin Suheda , Kusurkar Rashmi A. , Schreurs Hermien , Daelmans Hester , Peerdeman Saskia
Published: September 2024

Background

With a growing population of older people in all Western countries, interprofessional education (IPE) can help to prepare students for the complex care for these patients. Which aspects of this complex care could benefit from IPE? In this study we evaluated the differences in content of health care plans made by students who participated in IPE.

Methods

Undergraduate nursing and medical students were included and attended four sessions in which they wrote a health care plan for a paper-based geriatric patient case. Approximately half of the students were included in the IPE-group. To evaluate the content of interprofessional collaboration between the students, the other half of the students were included in a ‘uniprofessional education’ (UPE) group. UPE-students made the health care plan alone. In the IPE-group a medical and a nursing students compiled the health care plan together. All health care plans were assessed by comparing them with a validated health care plan. We zoomed into the differences in the content of the health care plans, and calculated a score ratio, proportion of correct items.

Results

The health care plans made by IPE-students had an average score ratio of 0.31. The health care plans made by UPE-students had an average score ratio of 0.22. Most differences were found in the subcategories medication, nursing actions and aftercare. Specific items within these categories were more frequently thought of in the IPE-group than in the UPE-group, for example delirium interventions and consultation with a transfer nurse.

Conclusion

This study gives insights into which health care actions are more often considered by interprofessional couples in IPE than by students in UPE. Awareness of these items in clinical practice could make a difference in the care for older patients.
Well-being policies and applicant attraction: The mediating role of employer brand personality
Authors: Dierickx Lucas , Van Hoye Greet , Kozusznik Malgorzata W. , Kanwal Hira
Published: September 2024

Increasingly, (potential) employees take their well-being into account when choosing or quitting jobs. However, we do not yet know whether and how organizations can influence applicant attraction by communicating their well-being policy within recruitment materials. Based on signaling theory, we hypothesize that a well-being policy functions as a signal through which potential applicants make inferences about employer brand personality (organizational warmth and competence), ultimately increasing organizational attractiveness and application intentions. Moreover, we examine whether the content of the well-being policy matters and compare (a) prevention versus promotion policies and (b) individual-level versus organizational-level policies. Two experimental studies among samples of Belgian employed potential applicants showed that a well-being policy increased organizational attractiveness and application intentions, while organizational warmth served as an explaining mechanism. Organizational-level well-being policies elicited higher application intentions compared to individual-level well-being policies, which was mediated by organizational warmth and competence. Moreover, we found that even in the presence of another strong signal (salary information), a well-being policy is still linked to increased applicant attraction. Lastly, a well-being policy increases organizational attractiveness especially when salary is average in comparison to when salary is above average.
Comprehensive endometriosis care: a modern multimodal approach for the treatment of pelvic pain and endometriosis
Authors: Mick Ido , Freger Shay M. , van Keizerswaard Jolanda , Gholiof Mahsa , Leonardi Mathew
Published: September 2024

Endometriosis is a prevalent gynecological disease, leading to chronic pain and inflammation, affecting 1 in 10 individuals presumed female at birth. The diagnostic journey is often arduous, marked by neglect of the right diagnosis and prolonged wait times, significantly compromising the quality of life among those affected. This review provides a nuanced exploration of endometriosis-associated pain management, encompassing medical, surgical, and holistic approaches, all guided by accurate and refined diagnostics. Our paramount goal is to empower physicians as key figures in confronting this intricate challenge with a patient-centric approach, ultimately aiming to improve treatment and quality of life. Acknowledging each patient’s unique needs, we emphasize the importance of tailoring a spectrum of options informed by current literature and insights gleaned from our experience in a high-volume tertiary endometriosis center. It is imperative to recognize endometriosis as a complex and chronic disease, often occurring with co-morbid conditions and nuanced complexities, necessitating a long-term personalized multimodal approach for each case. In addition, incorporating principles such as patient autonomy, profound respect for diverse experiences, and practical education on treatment choices is pivotal in enhancing treatment outcomes and overall patient satisfaction.
Computerized Principal Component–Canonical Discriminant Analysis Classification Model for Pollen Grain Identification Using Surface-Enhanced Raman Spectroscopy
Authors: Mert Sevda
Published: September 2024

Pollen identification and quantification are employed in various applications, and studies have been conducted to achieve precise automated pollen recognition to minimize the manual labor and subjectivity associated with human identification. The objective of the study was to evaluate the potential of surface-enhanced Raman spectroscopy (SERS) properties of pollen grain spectra, specifically within the spectral range of 582–1563 cm–1, using the convective assembly combined principal component–canonical discriminant analysis (PC-CDA) classification model. This research aimed to explore the feasibility of using this approach for the automated identification of pollen in the future. This approach facilitates the optimal arrangement of pollen grains and colloidal silver nanoprobes, thereby enhancing SERS spectra reproducibility using the convective assembly sampling method. Pollen grains can be characterized at a microscopic level without the need for purification-based analysis procedures. The findings demonstrate the possibility of rapid and accurate classification of pollen grains with the PC-CDA detection model with a 99.3% sensitivity, 97.6% specificity, and 98.5% accuracy. Research study indicates that the SERS properties of pollen spectra could serve as a promising method for automated pollen identification using the PC–CDA classification model.
Sustained benefit of zanubrutinib vs ibrutinib in patients with R/R CLL/SLL: final comparative analysis of ALPINE
Authors: Brown Jennifer R. , Eichhorst Barbara , Lamanna Nicole , O’Brien Susan M. , Tam Constantine S. , Qiu Lugui , Jurczak Wojciech , Zhou Keshu , Šimkovič Martin , Mayer Jiří , Gillespie-Twardy Amanda , Ferrajoli Alessandra , Ganly Peter S. , Weinkove Robert , Grosicki Sebastian , Mital Andrzej , Robak Tadeusz , Osterborg Anders , Yimer Habte A. , Wang Megan , Salmi Tommi , Wang Liping , Li Jessica , Wu Kenneth , Cohen Aileen , Shadman Mazyar
Published: September 2024

The ALPINE trial established the superiority of zanubrutinib over ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia and small lymphocytic lymphoma; here, we present data from the final comparative analysis with extended follow-up. Overall, 652 patients received zanubrutinib (n = 327) or ibrutinib (n = 325). At an overall median follow-up of 42.5 months, progression-free survival benefit with zanubrutinib vs ibrutinib was sustained (hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.54-0.84), including in patients with del(17p)/TP53 mutation (HR, 0.51; 95% CI, 0.33-0.78) and across multiple sensitivity analyses. Overall response rate remained higher with zanubrutinib compared with ibrutinib (85.6% vs 75.4%); responses deepened over time with complete response/complete response with incomplete bone marrow recovery rates of 11.6% (zanubrutinib) and 7.7% (ibrutinib). Although median overall survival has not been reached in either treatment group, fewer zanubrutinib patients have died than ibrutinib patients (HR, 0.77 [95% CI, 0.55-1.06]). With median exposure time of 41.2 and 37.8 months in zanubrutinib and ibrutinib arms, respectively, the most common nonhematologic adverse events included COVID-19–related infection (46.0% vs 33.3%), diarrhea (18.8% vs 25.6%), upper respiratory tract infection (29.3% vs 19.8%), and hypertension (27.2% vs 25.3%). Cardiac events were lower with zanubrutinib (25.9% vs 35.5%) despite similar rates of hypertension. Incidence of atrial fibrillation/flutter was lower with zanubrutinib vs ibrutinib (7.1% vs 17.0%); no cardiac deaths were reported with zanubrutinib vs 6 cardiac deaths with ibrutinib. This analysis, at 42.5 months median follow-up, demonstrates that zanubrutinib remains more efficacious than ibrutinib with an improved overall safety/tolerability profile. This trial was registered at www.ClinicalTrials.gov as #NCT03734016.
Neighborhood social cohesion and physical disorder in relation to social isolation in older adults: racial and ethnic differences
Authors: Qin Weidi , Nicklett Emily J. , Yu Jiao , Nguyen Ann W.
Published: September 2024

Background

Neighborhood factors of social isolation have been understudied, hindering efforts to reduce social isolation at the neighborhood level. This study aims to investigate the longitudinal effects of neighborhood social cohesion and physical disorder on social isolation in community-dwelling older adults, as well as to examine whether race/ethnicity moderates the neighborhood-isolation relationship.

Methods

We used 11-year data from the National Health and Aging Trend Study, a longitudinal national study of Medicare beneficiaries aged 65 and older. Social isolation was measured through a summary score across four domains: marital/partner status, family and friend contact, religious attendance, and club participation. A series of weighted mixed-effects logistic regression models were performed to test the study aims. Sample sizes ranged from 7,303 to 7,291 across individual domains of social isolation.

Results

Approximately 20% of participants reported social isolation. Findings indicated a negative association between neighborhood social cohesion and social isolation. Higher levels of neighborhood social cohesion were longitudinally associated with lower odds of social isolation (odds ratio [OR] = 0.52, 95% CI: 0.47–0.58). Yet, the presence of neighborhood physical disorder was associated with an increased risk of overall social isolation ([OR] = 1.2, 95% CI: 1.00, 1.44). Race/ethnicity significantly moderated the effects of neighborhood social cohesion and physical disorder on social isolation. The odds of no in-person visits associated with neighborhood social cohesion are smaller among Black adults compared to White adults. Black adults had constantly lower odds of isolation from religious attendance compared to White adults regardless of the level of neighborhood social cohesion. Hispanic adults had decreased odds of having no friends associated with signs of physical disorder, while no associations were found among older White adults. White adults had higher odds of isolation from in-person visits when living in neighborhoods with signs of physical disorder, whereas no association was observed among older Black and Hispanic adults.

Conclusions

This study elucidates the role of neighborhood characteristics in shaping social isolation dynamics among older adults. Furthermore, the observed moderation effects of race/ethnicity suggest the need for culturally sensitive interventions tailored to address social isolation within specific neighborhood and racial contexts.
Determining the predictors of preventive behaviors adopted by pregnant women against COVID-19 based on the Health Belief Model constructs: a cross sectional study
Authors: Bayrami Roghieh , Masudi Sima , Didarloo Alireza , Nournezhad Homeira
Published: September 2024

Background

Pregnant women face great challenges during the coronavirus disease 2019(COVID-19) pandemic. The purpose of this study was to explain the main dimensions of adoption of self-care behaviors against COVID-19 based on the health belief model(HBM) in pregnant women.

Methods

This cross-sectional and analytical study was conducted in Iran, at the end of the third wave of the COVID-19 pandemic, between January and April 2021. Two hundred and thirty pregnant women who referred to Urmia health centers were selected using multi-stage random sampling. The data were collected using an online questionnaire including items that measured the participants’ demographic characteristics, the knowledge questionnaire, the HBM items, and questions assessing the adoption of self-care behaviors against COVID-19. The data were analyzed using SPSS software version 20. Descriptive statistics, bivariate Pearson’s correlation test, and multiple linear regression were used to analyze the data.

Results

The results of this study showed that the rate of self-care behaviors against COVID-19 in the pregnant women participating in the present study was not very favorable. It was also shown that among the constructs of the HBM, knowledge, self-efficacy, and perceived barriers were the most important predictors of adopting self-care behaviors with a variance of 24% change among the pregnant women.

Conclusion

Knowledge, self-efficacy, and perceived barriers were found in this study as the strongest predictors of self-care behaviors among pregnant women. Thus, it is suggested to implement interventions commensurate with the results of this study.
Hippocampal sclerosis in women with temporal lobe epilepsy: seizure and pregnancy outcomes
Authors: Chen Yujie , Hao Nanya , Xiong Weixi , Zhang Hesheng , Zhang Enhui , Ou Zhujing , Chen Lei , Wu Xintong , Zhou Dong
Published: September 2024

Background

Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is typically resistant to pharmacological interventions; however, achieving seizure freedom is possible through surgery. Our objective was to focus on the pregnancy and seizure outcomes during pregnancy of women with TLE-HS, and aim to identify predictors of seizure control.

Methods

The West China Registry of Pregnancy of Women with Epilepsy (WCPR_EPi) was a monocentric prospective cohort study of women with epilepsy (WWE). We screened women with TLE-HS in this database. Their clinical profile, anti-seizure medication (ASM) use, and pregnancy outcomes were extracted from the records of the registry (2010–2023).

Results

Out of 2320 WWE followed up, 47 pregnancies in women with TLE-HS were identified and analyzed. Seizure exacerbation occurred in 40.4% of pregnancies, and seizure freedom was present in 34.0% of these during pregnancy. Factors associated with seizure exacerbation during pregnancy was ASM non-adherence (odds ratio [OR] =7.00, 95% confidence interval [CI] 1.43–34.07, P=0.016). The surgery group showed a significantly higher seizure freedom rate (OR = 6.87, 95% CI 1.02–46.23, P=0.016) and lower rate of induced labor (0.0% vs 26.5%, P=0.047) compared to the medically-treated group alone. Caesarean section was chosen in 77.1% of cases due to seizure concerns, with comparable in epilepsy-related (n=20) and obstetric causes (n=24). No major congenital malformations were reported.

Conclusions

Surgical treatment before pregnancy appears to offer a higher chance of seizure freedom compared to medication alone. Most of women with TLE-HS can deliver healthy offspring regardless of suboptimal seizure control and unwarranted concerns.
Simultaneous beating-heart mitral valve replacement and aortic repair following Bentall procedure via double right mini-thoracotomies: a case report
Authors: Tanaka Toshimasa , Kinoshita Takeshi , Endo Daisuke , Tabata Minoru
Published: September 2024

Background

Redo mitral valve surgery by re-sternotomy approach has challenges such as bleeding and organ injury due to adhesion dissection, sternal bone infection, and poor field of view of mitral valve. On the other hand, redo mitral valve surgery via a right mini-thoracotomy approach appears to address these challenges. We successfully performed a double right mini-thoracotomies approach for mitral valve replacement and pseudoaneurysm repair under the beating-heart condition. Herein, we report the effectiveness and the safety of this technique and detailed procedure.

Case presentation.

The patient is a 71-year-old man with a history of Bentall procedure using a mechanical valve at another hospital 30 years ago. He developed acute heart failure due to severe mitral valve regurgitation. After medication, he was referred to our department for the purpose of surgery for mitral valve regurgitation. Preoperative transesophageal echocardiography showed extensive degenerative change of the both leaflets and chordae tendineae rupture at the P3 segment. Both left atrium and ventricle dilated, and left ventricle contractility reduced. Aortic mechanical valve had no problem. In addition, preoperative contrast enhanced computed tomography revealed a pseudoaneurysm at the distal anastomotic site of Bentall procedure. We performed mitral valve replacement by mechanical valve and repair of distal anastomotic cite under beating heart condition, utilizing a double right mini-thoracotomies approach for mitral valve and ascending aortic pseudoaneurysm respectively. The postoperative course was uneventful, the patient was discharged without complications.

Conclusion

The right mini-thoracotomies approach efficiently accessed mitral valve and ascending aorta in reoperations, reducing the adhesion dissection risks and ensuring clear exposure. Moreover, concomitant use of beating-heart technique minimized adhesion dissection for aortic cross-clamp, preserved cardiac function.
Partial Lipodystrophy Affecting the Extremities in a Young Woman With Autoimmune Polyglandular Syndrome 1
Authors: Agarwal Shubham , Bodansky Aaron , Xing Chao , Anderson Mark S , Garg Abhimanyu
Published: September 2024

Autoimmune polyglandular syndrome 1 (APS1) is an autosomal recessive disorder due to biallelic pathogenic variants in the autoimmune regulator (AIRE) gene that manifests with chronic mucocutaneous candidiasis, primary hypoparathyroidism, and adrenal insufficiency. We report a 39-year-old woman with APS1 who developed partial lipodystrophy during adulthood. She presented with diaper rashes, oral thrush, and tetany during infancy due to candidiasis and hypoparathyroidism. During childhood, she developed hypothyroidism, primary adrenal insufficiency, and ovarian insufficiency.

At age 14, she received a sibling-matched allogenic bone marrow transplant due to multiple antibiotic-refractory fungal infections. At age 35, her serum triglycerides were 914 mg/dL (10.32 mmol/L) and she had loss of subcutaneous fat from the upper and lower extremities and hips. A whole-body dual-energy x-ray absorptiometry revealed lower-extremity fat at less than the first percentile. Whole-exome sequencing on DNA extracted from saliva revealed pathogenic variants, p.Leu28Pro and p.Arg257* in AIRE but none in the known lipodystrophy genes. Phage-immunoprecipitation-sequencing revealed the presence of autoantibodies to MAGEB1, MAGEB4, and RFX6, which have been previously reported in APS1. Our case suggests that patients with APS1 may develop partial lipodystrophy due to autoantibodies against novel adipocyte-expressed proteins. A causal relationship of high levels of autoantibodies in our patient to adipose tissue–expressed ODC1, NUCKS1, or FNBP1L and lipodystrophy remains uncertain.
In-Home Intravenous Dexmedetomidine Infusion for Treatment of Dystonia: A Pediatric Case Report
Authors: Richner Gwendolyn J. , Allen Stephanie S. , Adair Lindsay M. , Grossoehme Daniel H. , Kelly-Langen Catherine A. , McNair Wendy J. , Williams Madelyne L. , Friebert Sarah
Published: September 2024

The off-label use of an intravenous dexmedetomidine infusion is an option for refractory symptoms in pediatric palliative care with a few published cases of in-home use, most limited to end-of-life care. After an intrathecal baclofen pump malfunction with meningitis and medication withdrawal, a 17-year-old adolescent with quadriparetic cerebral palsy and paroxysmal autonomic instability experienced relief of refractory pain and dystonia with an in-home intravenous dexmedetomidine infusion. His interdisciplinary care team collaborated to establish safety measures and adjust his home medication regimen to further improve quality of life well before his end of life.