Effects of probiotics on inflammatory bowel disease: A systematic review
Authors:   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Lopes Gabriela , Sorrentino dos Santos Campanari Gyovanna ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Barbalho Sandra M ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Matias Júlia Novaes ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Lima Vinícius Marinho ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Araújo Adriano Cressoni ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Goulart Ricardo de Alvares ,   Postgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR – Marília-SP, Brazil, Detregiachi Claudia Rucco P ,   Postgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR – Marília-SP, Brazil, Santos Haber Jesselina F ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Alves de Carvalho Antonelly Cassio ,   Postgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR – Marília-SP, Brazil, Alvarenga Luiz Henrique ,   Postgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR – Marília-SP, Brazil, Ullman Thais de Oliveira ,   Postgraduate Program in Structural and Functional Interactions in Rehabilitation-UNIMAR – Marília-SP, Brazil, Bueno Patrícia C Santos ,   Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., Guiguer Élen Landgraf ,   School of Food and Technology of Marilia (FATEC) – Marilia – SP, Brazil.
Published: December 2021

Inflammatory Bowel Disease (IBD) is a chronic idiopathic inflammation of the gastrointestinal tract, characterized by periods of exacerbation and remission, which includes two primary forms: Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is an autoimmune disorder influenced by genetics, hereditary, environment, and infection. Alternative treatments with fewer side effects have been searched. Thus, the use of probiotics stands out due to several beneficial effects. For this reason, the objective of this systematic review is to evaluate the effects of the use of probiotics in patients diagnosed with IBD. This review included studies available in the MEDLINE databases - PubMed, EMBASE, and Cochrane, and the final selection included thirteen randomized clinical trials. The results showed that the oral use of probiotics and, mainly for a prolonged period, can help in the improvement of reducing symptoms related to IBD. In endoscopic analyzes, a reduction in intestinal inflammation was noted, in addition to a reduction in proinflammatory cytokines. Although there are positive effects, there is a need for further studies to define the best composition of probiotics and time of use since there are many variations in this treatment.