bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenetic substantiation of personified correction of folate cycle disorders using a complex with metapholine for the congenital malformations prevention
Authors: І. В. Руденко  , В. П. Міщенко
Published: September 2020

Congenital malformations are pathology with a multifactorial etiology. Among their many endogenous, exogenous factors and hereditary predisposition are important. In particular a decrease in follicular enzymes (MTHFR, MTR, MTRR) activity at the genetic level, as well as a deficiency of vitamins and vitamin-like compounds of group B.Objective: to provide a pathogenetic justification for personified correction of disorders in the folate cycle in biological parents preparing for pregnancy to prevent congenital malformations in their children by using folates containing metafolin (5-MTHF).Materials and methods. The study involved 75 women and 75 men (biological parents) who had children/fetuses with congenital malformations in previous pregnancies, and 75 newborn children of these couples. All of them used the proposed preconceptional preparation. Alleles of folate cycle enzyme genes (MTHFR, MTR, MTRR) were determined by polymerase chain reaction in blood and saliva.Results. A high frequency of polymorphism of the folate cycle enzyme genes was observed in men among subjects (father, mother, child). The indicator was 77.7% compared with 68.7% in mothers and 60.7% in their children. The frequency of homozygous alleles was highest in parents (men) – 19.6%, lower in mothers – 13.1% and in children – 12.7%. Result of heterozygous alleles decreased from children indicator (87.3%) to their mothers (86.7%) and parents (80.4%).Conclusions. Obtained results emphasize the practical importance for determining the alleles of the folate cycle enzyme genes (MTHFR, MTR, MTRR) at the stage of preconception preparation for pregnancy in biological parents and then in their newborn children from the standpoint of preventive medicine. Reduced activity of the corresponding enzymes pathogenetically explains the feasibility of using folate complexes containing active folate metafolin (5-MTHF) in order to prevent congenital malformations.
Pregravid preparation of women with polycystic ovary syndrome.
Authors: Г. О. Ісламова
Published: September 2020

Polycystic ovary syndrome (PCOS) is a significant component in the structure of diseases that cause female infertility, and the most common cause of ovarian dysfunction in women of reproductive age. This disease significantly increases the risk of miscarriage, the development of preterm labor, and increases the incidence of perinatal complications such as gestational diabetes, fetal macrosomia, and gestational hypertension.A comparative prospective study was conducted with 60 patients of reproductive age suffering from PCOS (phenotype A) and having an increased body mass index. At the beginning of the study, all patients received recommendations about an individually selected reduction diet, a set of physical exercises, and adherence to an eight-hour night's sleep regimen. By random sampling, the patients were divided into 2 groups of 30 people each. For 6 months, the patients of the main group received twice a day 1 sachet Miofolik. 1 sachet contains: myo-inositol 2000 mg, vitamin B12 5 μg, folic acid ((68)-5-methyltetrahydrofolate) 200 μg. Patients in the control group did not receive drug support, observing dietary recommendations and performing a set of physical exercises only.An analysis of the results of the study of the drug Myofolik in women with PCOS indicates its positive complex effect on metabolic disorders (improved lipid and carbohydrate metabolism), decreased hyperandrogenia, restoration of the ovulatory cycle (decreased levels of LH and LH / FSH, increased levels of estradiol, progesterone), which accordingly significantly increases the chances of pregnancy. The results of the study allow us to recommend the drug Miofolik for pregravid preparation in patients with polycystic ovary syndrome.
Effectiveness of the preventive use of folic acid and complex with active folates in women with MTHFR C677T genetic polymorphism and with history of embryonic loss
Authors: О. Б. Ластовецька  , О. В. Булавенко  , Д. Г. Коньков  , В. В. Буран
Published: September 2020

Objective: to evaluate the clinical efficacy and safety of Femibion Natalcare vitamin complex containing metafolin in women of late reproductive age with MTHFR C677T genetic polymorphism who had anamnestic embryonic losses.Materials and methods. Study included 100 women of late reproductive age with MTHFR C677T genetic polymorphism and anamnestic embryonic losses. Patients of main group were divided in subgroups: first – 45 women who received folic acid (400 mcgper day) and second – 55 patients who received vitamin complex Femibion Natalcare 1 tablet  daily. Prescription of medications began before preconception (6–8 weeks), intake ended at 28 weeks of gestation. Control group included 40 healthy women with physiological pregnancy. The studied parameters reflected information about the features of the pregnancy and birth.Results. After a course of prophylactic supplementation with Femibion Natalcare compared with monotherapy of folic acid, it was possible to reliably reduce cases of early pregnancy loss (p =0.03), anemia in I trimester (p =0.009), preeclampsia (p =0.014), anemia in II and III trimesters (p =0.001), placental dysfunction (p =0.0005), decrease in the level of placental hormones (p =0.014), pathology of placental development and localization (p =0.0499), fetal growth retardation (p =0, 0499), premature maturation of placenta (p =0.02), induction of labor (p =0.015), disorders of neonatal adaptation (p =0.03), neonatal jaundice (p =0.018), postpartum anemia (p =0.015). There were no cases of side effects of drugs on the mother and child.Conclusions. The use of a vitamin complex containing active folate metapholine for women of late reproductive age with MTHFR C677T genetic polymorphism and anamnestic embryonic losses had a positive effect on clinical symptoms, helps to reduce cases of perinatal pathology and impaired early neonatal adaptation.
Imagem Técnica e Imagem Turística: considerações sobre o Instagram como motivador para o turismo
Authors: Moraes Conceição Renan Augusto
Published: September 2020

Com um mercado que atrai investimentos maciços em publicidade, o turismo movimenta cerca de 1 trilhões de dólares ao ano, segundo a Organização Mundial do Turismo. Deste modo, as empresas turísticas investem em publicidade nas mais variadas formas e redes sociais, como o Instagram, são uma forma de propagação dessa publicidade, impulsionando o desejo pela atividade turística. O objetivo desse artigo é caracterizar o Instagram como um propagador de imagens turísticas de caráter técnico, em que o uso de imagens publicitárias para o turismo ocorre de maneira intensiva e intencional. De caráter bibliográfico, pois se fundamenta nas obras de autores como Belting (2007), Flusser (2011, 2013), Sartre (2008) e Wulf (2013); documental e jornalístico, uma vez que analisa material imagético e de veículos como o jornal El Pais; e exploratório, levantando informações sobre o uso de imagens por alguns usuários do Instagram, essa pesquisa tem como resultado a detecção de padrões nas imagens publicitárias veiculadas no Instagram, originando um movo de vida pautado pela publicidade espontânea, tornando os usuários de aplicativos de imagens em agências de publicidade turística ambulante.Palavras-chave: Turismo e publicidade, imagem técnica, Instagram
INVESTIGATING THE ROLE OF ISSUING CORPORATE ISLAMIC BOND AND SELECTED DETERMINANTS ON FIRM'S PROFITABILITY
Authors: Najmudin  , Widiastuti Ekaningtyas , Taufiqurrahman Ghifari
Published: September 2020

Purpose of the study: The purpose of this study is to investigate the effect of corporate Islamic bond issuance, internal and macroeconomic factors on firm's profitability. The internal factors involved potentially as determinants of profitability are leverage and firm size. Meanwhile, the macroeconomic factors are economic growth and the inflation rate.

Methodology: The sample is taken from companies listed at Indonesia Stock Exchange (IDX) and selected from 24 companies. The sample is 21 companies whose data completely and issued the Islamic bond during the period 2012 until 2018. Moreover, the panel data regression was employed as an analytical tool to test the data.

Main Findings: The results suggest that Islamic bond issuance and financial leverage have a negative influence on profitability, firm size has no significant influence on profitability, and economic growth and inflation rate have a positive influence on profitability.

Applications of this study: A firm, as well as an investor, must consider the lower Islamic bond issuance and debt proportion. Besides, they should anticipate decreased economic growth and the inflation rate.

Novelty/Originality of this study: This study observes evidence from Indonesia Stock Exchange (IDX) that develops the previous studies and adds references for further studies about Islamic bond issuance. Also, it combines Islamic fund source and firm-specific internal as well as macroeconomic factors (economic growth and inflation rate) macroeconomics factors insert what are the macroeconomic factor which affects the profitability of the business to give a clear picture of how the effect of all factors on profitability.
IMPACT OF SUPPLY CHAIN MANAGEMENT PRACTICES ON SUPPLY CHAIN PERFORMANCE IN IRANIAN OIL AND GAS COMPANIES
Authors: E-Vahdati Sahar , Akbari Mohsen , Habibi Khosro
Published: September 2020

Purpose of the study: This study aims to examine the influence of supply chain management practices on the performance of the supply chain in oil and gas companies in Iran.

Methodology: This is quantitative survey-based research and sampling is a simple random in which data are collected through a standard questionnaire. The questionnaires are distributed among 170 respondents in west oil and gas companies in Iran. The sample consists of 78% male and 22% female, who are mostly from the age range of 35-45. For hypotheses testing, descriptive statistics and structural modeling systems are used through SPSS and AMOS software to investigate the relationships between variables.

Main Findings: The finding reveals that all supply chain management practices, namely supply chain unity, information sharing, and partner relationship management, have a significant positive impact on supply chain performance.

Applications of this study: The findings of the study can be implemented in the oil and gas industry to enhance supply chain performance. Besides, chain managers will understand the effects of implementing effective and high-quality supply chain unity, information sharing, and partner relationship management in performing of the supply chain in their companies.

Novelty/Originality of this study: This study contributes to the literature by utilizing the social exchange theory in the relationship between supply chain management practices and supply chain performance in oil and gas companies.
FACTORS AFFECTING THE WILLING TO JOIN IN COFFEE CROP INSURANCE IN DAK LAK PROVINCE, VIETNAM: A NOVEL APPLICATION OF BAYESIAN MODEL AVERAGING APPROACH
Authors: Dinh Thang Le , Van Si Nguyen
Published: September 2020

Purpose of the study: this paper aims to determine factors affecting the willingness to join crop insurance. Besides, this paper is the purpose of developing a coffee tree insurance program.

Methodology: The authors used a systematic random sampling technique. The authors used the Bayesian Model Average (BMA) that calculated the probability of all independent variables affecting the dependent variable with significance level 0.05. Besides, the data based on 480 coffee farmers in Dak Lak province, Vietnam.

Main Findings: Authors calculated the probability of all independent variables affecting the dependent variable with significance level 0.05. Independent variables, including loans, drought risks, educational level, experiences, and productivity.

Applications of this study: This result is a vital science document for insurance companies and managers to apply and suggest recommendations for developing coffee tree insurance in the future.

Novelty/Originality of this study: Vietnam is an agricultural country, 60-70% of the population lives in rural areas, and agricultural insurance should have a considerable market. Farmers’ agrarian insurance cultivated the coffee trees that are currently underdeveloped and challenging.
Boyun ve mediasten tutulumlu hodgkin lenfoma olgularında Butterfly VMAT tekniği avantajlı mıdır?
Authors: ATASEVER AKKAŞ Ebru , GÜVENÇ Olgu
Published: September 2020

Amaç: Bu çalışmada, erken evre Hodgkin lenfoma (HL) tanılı bilateral boyun ve mediasten yerleşimli genç kadın ve erkek olgularda, üç boyutlu konformal radyoterapi (3DCRT) ile volumetric modulated arc therapy (VMAT) ve butterfly VMAT tekniklerinin dozimetrik olarak karşılaştırılması amaçlanmıştır.

Gereç ve Yöntemler: Erken evre HL'lı 20 hastaya radyoterapi uygulandı. Tüm plan verileri, hedef hacim ve kritik organ doz hacim histogramları karşılaştırıldı. Her üç teknik için konformite indeksi, homojenite indeksi ve % V107 farklılıkları değerlendirildi.

Bulgular: Sağ meme maksimum, V25, V30 ve sol meme maksimum, V20, 25, 30 değerleri ise 3DCRT planlamada diğer VMAT planlarında elde edilen değerlerden daha yüksek idi. Bu da istatistiksel olarak anlamlı bulundu. Akciğer V5 değerleri 3DCRT planlamasında, VMAT planlarından daha düşüktü ve V20, 25,30 değerleri ise VMAT planlarından istatistiksel olarak daha yüksekti. Sağ ve sol parotis ortalamaları, V5,20 25, 30 değerleri butterfly VMAT planlamasında diğer planlara göre anlamlı olarak daha düşüktü. Sağ parotis V20, V25 değerinin butterfly VMAT planlamasında, ikili karşılaştırmalarda VMAT planından daha düşük olduğu bulunmuştur.

Sonuçlar: Memede 20 Gy ve üzerinde VMAT, butterfly VMAT, 20 Gy ve altında ise 3DCRT tekniğinin daha avantajlı olduğu görülmektedir. Parotis dozları açısından ise butterfly VMAT’ın daha avantajlı olduğu görülmektedir.
Effects of isoflurane, ketamine and dantrolene on apoptosis in the rat hippocampus
Authors: KARTAL Seyfi , GÜNAYDIN Berrin , BARUN Süreyya , ELMAS Çiğdem
Published: September 2020

Aim: Since both isoflurane and ketamine were already known to cause neurodegenerative apoptotic effects and dantrolene was known to inhibit degeneration, we investigated whether dantrolene could play a cytoprotective role under isoflurane and/or ketamine anesthesia. Therefore, we aimed to determine caspase activation as a marker of apoptosis in hippocampus (CA1 and dentate gyrus regions) of rats exposed to either administration of isoflurane with or without ketamine and dantrolene or isoflurane+ketamine+dantrolene.

Material and Methods: Thirty Wistar male rats were randomly assigned to five groups. Only oxygen 100% was administered into the closed cage for 2 hours in the control group (group A) whereas in the four study groups (as B,C,D and E), either 1.4% isoflurane alone in 100% oxygen was administered (group B) or 1.4% isoflurane in 100% oxygen was administered 60 minutes after intraperitoneal (ip) injection of dantrolene 10 mg/kg (group C), subcutaneous (sc) ketamine 40 mg/kg (group D) or ip dantrolene + sc ketamine (group E). Rats were sacrified to perform histopathologic and immunohistochemical analysis (hematoxylin staining caspase activation).

Results: Isoflurane alone (group B) and isoflurane+ketamine (group D) exposure to rats resulted in a significantly increased caspase activation when compared to control (group A) and dantrolene inhibited isoflurane + ketamine induced apoptosis in the hippocampus. Conclusion: Isoflurane with or without ketamine caused neuroapoptosis in rats and dantrolene attenuated the apoptotic effect of both isoflurane and isoflurane+ketamine by decreasing caspase activation. These results might have an important promising role in anesthetic choice for specific susceptible group after further clinical studies.
A Constituição Federal brasileira e suas controvérsias interpretativas: uma perspectiva pragmática
Authors: Domingos Crisbelli , Zanotti Marina Godoy
Published: September 2020

Desenvolvemos neste trabalho uma proposta de análise da interpretação jurídica da Constituição Federal Brasileira, envolvida na criação das Súmulas Vinculantes instituídas pelos magistrados do poder judiciário em suas cortes. Utilizamos a perspectiva da pragmática cognitiva para construir uma base epistêmica mais sólida sobre o conceito de interpretação forense. Com isso, buscamos elucidar, tanto aos juristas como aos linguistas, que a integração da pragmática à concepção desse tipo de interpretação é capaz de oferecer um modelo teórico mais aprofundado do que as abordagens estritamente sociológicas, recorrentes nesse tipo de estudo. A relação controversa da interpretação da lei entre um tribunal e outro, no exemplo prático utilizado, torna oportuna uma outra maneira de avaliar o processo de interpretação jurídica
A imagem do ser enfermeira/enfermeiro em filmes de longa metragem à luz da história da enfermagem
Authors: Dos Santos Allan Ferreira , Barbosa Elane Da Silva , Chaves Márcia Jaínne Campelo , Fernandes Helder Matheus Alves , Nóbrega-Therrien Silvia Maria
Published: September 2020

Objetiva-se analisar a imagem de Enfermagem veiculada nos filmes de longa-metragem, apresentando o perfil de enfermeira (o) enfocado e refletindo sobre o significado das informações veiculadas nas cenas desses filmes. Trata-se de estudo de abordagem qualitativa, do tipo analítico e descritivo, no qual foram analisados três filmes: Um estranho no ninho (1975); Servindo em silêncio (1995) e Fale com ela (2002). Identifica-se que a(o) enfermeira(o) apresenta distintas imagens nos longasmetragens, transitando de uma imagem feminina maquiavélica em Um Estranho no Ninho, para um aspecto rígido, desumanizado e masculinizado com a enfermeira em Servindo em silêncio, chegando à perspectiva de um profissional humanizado, sensível e empático em Fale com Ela, cuja orientação sexual é questionada, o que traz à tona da discussão da feminização da categoria. Constata-se, portanto, que o cinema retrata a(o) enfermeira(o) sob diversas imagens, assim desvelá-las torna-se fundamental para fortalecer o papel desse profissional, sem estereótipos.
A Case Report of Cervicitis Gonorrhea
Authors: Indramaya Diah Mira , Ahmad Zahruddin , Widyantari Septiana
Published: September 2020

Background: Gonorrhea refers to a set of clinical conditions involving infection with the sexually acquired bacterial pathogen, Neisseria gonorrhoeae. One of the simplest gonococcal infections in women involves mucosal surfaces of the endocervix that cause cervicitis, a frequently asymptomatic inflammatory condition that results in an abnormal mucopurulent discharge and cervical friability. Purpose: To report a case of cervicitis gonorrhea in a female patient whose sexual partner had a hisstory of unprotected promiscuous intercource with multiple sex worker. Case: A 24-year-old female patient presented with increased vaginal discharge for 4 days. Her husband had a history of having sexual intercourse with a sex worker 8 days before. Physical examination revealed mucopurulent exudate in the genitalia and endocervical canal. The Gram staining showed numerous leucocytes and Gram-negative intracellular diplococci, while the result of polymerase chain reaction (PCR) examination for Chlamydia trachomatis was negative. The patient was treated with single-dose cefixime 400 mg orally and doxycycline 100 mg orally twice a day for 7 days. Discussion: The present case report showed cervicitis gonorrhea co-infected with a nonspecific genital infection that was felt asymptomatic and unintentionally found when the patient accompanied her husband to Sexually Transmitted Infection (STI) clinic. The presumptive treatment of cervicitis directed against N. gonorrhoeae and C. trachomatis in this patient leads to a complete cure of the disease. Conclusion: It is important to treat the sexual partner of a patient with urethritis gonorrhea. The empiric treatment of cervicitis that is directed against N. gonorrhoeae and also against C. trachomatis is mandatory in preventing further possible complications.
Side Effects of Methotrexate for Psoriasis Therapy
Authors: Agustina Melida , Hidayati Afif Nurul , Hasanatuludhhiyah Nurina
Published: September 2020

Background: Psoriasis is a chronic and relapsing inflammatory disease of the skin, characterized by the presence of well-defined erythematous plaque covered by silvery-white scales. Methotrexate is a folic acid antimetabolic for psoriasis therapy and given systemically so unexpected effects can occur. Purpose: To evaluate the side effects of methotrexate as therapy in psoriasis. Methods: The descriptive research based on the medical record of psoriasis patients who were treated for hospitalization on at Kemuning I and II ward Dr. Soetomo General Academic Hospital Surabaya during the period January 2017 – December 2018. The sampling method used was total sampling. Result: Twenty two psoriasis patients receiving methotrexate therapy with the dose of methotrexate is 10-15 mg once weekly, there were 4.5% low erythrocyte level, 27.3% high leukocyte level, 13.6% high thrombocyte level, 18.2% high SGOT level, 22.8% high SGPT level, 18% nausea, 9.1% vomiting, 4.6% headache, and 4.6% shortness of breath. Conclusion: Methotrexate for psoriasis therapy may cause several side effects even not the severe ones, therefore careful dosing and side effect monitoring are necessary.
Improving the Quality of Learning Through Academic Supervision (Study in SMP Negeri 14 Banjarbaru)
Authors: Rachman Aidil Abdi
Published: September 2020

Terdapat beberapa cara untuk meningkatkan mutu pendidikan di antaranya dengan supervisi. Artikel ini bertujuan untuk mendeskripsikan supervisi akademik yang dilakukan di SMP Negeri 14 Banjarbaru dengan Penelitian Tindakan Sekolah (PTS) dalam kerangka meningkatkan motivasi guru dalam menyusun administrasi mengajar. Empat tahap pelaksanaan : (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi. Hasil penelitian menunjukkan bahwa guru serius dalam memahami dan menyusun administrasi mengajar setelah mendapatkan bimbingan pengembangan administrasi mengajar/RPP dengan peningkatan rata-rata dalam penyusunan administrasi mengajar sebesar 27, 91%. Berdasarkan observasi terjadi peningkatan kompetensi guru dalam mengajar dari siklus ke siklus dengan peningkatan rata-rata dalam perencanaan pembelajaran sebesar 17, 91%.
Bonding Social Capital in Social Activities of Urang Banjar in the Martapura Riverbank
Authors: Subiyakto Bambang , Sari Nina Permata , Mutiani Mutiani , Faisal M , Rusli Rusli
Published: September 2020

Kekuatan modal sosial dijelaskan secara teoritis melalui tiga tipologi, yaitu; bonding social capital, bridging social capital, dan linking social capital. Artikel ini bertujuan mendeskripsikan satu tipologi modal sosial yakni sistem perekat (bonding social capital). Perihal ini dimaksudkan agar memberikan analisis nilai apa yang menjadi pengikat-perekat pada Urang Banjar. Penelitian dilakukan di tiga kelurahan yang berbeda, antara lain: sungai jingah, sungai bilu, dan kuin. Pemilihan lokasi untuk memberikan representasi aktivitas sosial Urang Banjar di bantaran sungai. Pendekatan kualitatif dengan metode deskriptif digunakan pada penelitian. Observasi, wawancara, dan dokumentasi dilakukan untuk mengumpulkan data penelitian. Analisis data model Miles dan Huberman yakni: reduksi data, penyajian data secara naratif, dan penarikan kesimpulan menghasilkan data yang redundan. Adapun uji keabsahan data dilakukan dengan teknik triangulasi. Hasil penelitian mendeskripsikan bonding social capital diwujudkan dalam aktivitas sosial gotong royong. Adapun aktivitas gotong royong tersebut antara lain; mengawah, babarasih, batimbuk/manimbuk, dan bahandil. Bonding social capital dipengaruhi oleh rasa kepercayaan satu sama lain. Kepercayaan kemudian dijadikan sebagai pegangan dalam berinteraksi sosial untuk mewadahi asosiasi sosial internal keluarga.
Social Services in The Sosial Home Tresna Werdha Budi Sejahtera Banjarbaru
Authors: Yani Putri , Syaharuddin Syaharuddin , Putra Muhammad Adhitya Hidayat
Published: September 2020

Pelayanan sosial di panti sosial Tresna Werdha berpusat pada lima tahapan pelaksanaan pelayanan sosial. Hal ini dikarenakan panti sosial Tresna Werdha (PSTW) mempunyai ciri khusus yang tidak dimiliki oleh panti sosial lainnya dengan memberikan pelayanan sosial kepada lanjut usia yang mempunyai spesifik berbeda antara satu dengan yang lainnya, baik yang berkaitan dengan tingkah laku masing-masing individu, fisik dan kemampuan karena faktor usia yang dialami oleh lanjut usia pada umumnya secara terus menerus sampai lanjut usia merasa cukup untuk tinggal di panti atau sampai akhir hidup mereka. Sejalan dengan konsep pelayanan sebagai aktivitas dan keterkaitannya dengan sumber pembelajaran IPS. Pendekatan kualitatif digunakan dalam pendekatan ini dengan menggunakan metode deskriptif dan data yang didapatkan melalui observasi, wawancara dan dokumentasi di tempat penelitian. Data yang didapat direduksi, disajikan dalam bentuk narasi yang dilengkapi dengan gambar dan tabel yang selanjutnya dapat ditarik kesimpulan. Keabsahan data melalui triangulasi waktu, sumber dan teknik. Hasil penelitian menunjukkan bahwa pelayanan sosial yang ada di panti sosial Tresna Werdha Budi Sejahtera Banjarbaru adalah satu langkah untuk memberikan bantuan kepada lanjut usia sesuai dengan kebutuhan masing-masing lanjut usia yang dijalankan berdasarkan rencana dan terus berlanjut.
The Caring Attitudes for Environment of Lanting Householders as a Learning Resource on Social Studies
Authors: Ahya Rahmad Rizaldi , Syaharuddin Syaharuddin , Rahman Akhmad Munaya
Published: September 2020

Sikap peduli lingkungan merupakan satu aspek yang penting untuk diajarkan kepada kepada peserta didik, untuk menumbuhkan pemahaman kepada peserta didik mengenai lingkungan, sehingga mereka memiliki sikap untuk selalu menjaga dan melestarikan lingkungan. Pembelajaran IPS merupakan mata pelajaran yang dapat dimanfaatkan untuk menanamkan sikap peduli lingkungan kepada peserta didik, melalui pemanfaatan sumber belajar. Tujuan penulisan artikel ini adalah untuk mendeskripsikan sikap peduli lingkungan masyarakat di rumah lanting, serta keterkaitannya sebagai sumber belajar IPS.. Pengumpulan data diperoleh dari hasil observasi dan wawancara di lingkungan masyarakat penghuni rumah lanting. Subjek dalam penelitian ini adalah masyarakat penghuni rumah lanting. Analisis data yang digunakan  reduksi data, kemudian penyajian data, dan terakhir yaitu verifikasi. Uji keabsahan data  menggunakan triangulasi. Hasil penelitian didapatkan bahwa terdapat empat sikap peduli lingkungan penghuni rumah lanting, yaitu (1)tidak membuang sampah sembarangan ke sungai, (2) menggunakan produk ramah lingkungan, (3) melakukan kebersihan lingkungan sekitar rumah lanting, (4) mendaur ulang sampah. Sikap peduli lingkungan penghuni rumah lanting dapat digunakan sebagai sumber belajar IPS pada materi keragaman etnik dan budaya, dinamika interaksi manusia dengan lingkungan, dan interaksi manusia dengan lingkungan alam sosial, budaya, dan ekonomi.
INFLUÊNCIA DOS DEJETOS DA CAPRINOCULTURA NA COMPOSIÇÃO DE SUBSTRATOS PARA PRODUÇÃO DE MUDAS DE Anadenanthera peregrina (L) Speg.
Authors: Campos Aguiar Bruno Aurelio , Da Silva Norivania Diniz , Reis Sousa Mirlla Rayra , Santos Bárbara Maria Martins , Souza Flávia Bezerra , Souza Priscila Bezerra de
Published: September 2020

O esterco caprino é um material orgânico que pode ser uma alternativa para a formulação de substratos para produção de mudas de espécies nativas. O trabalho foi conduzido em um viveiro, coordenado em delineamento experimental inteiramente casualizado com cinco tratamentos: T1 – Terra de subsolo (TS) (100%), T2 – Terra de subsolo (TS) + Esterco caprino (EC) (75%:25%), T3 – Terra de subsolo (TS) + Esterco caprino (EC) (50%:50%), T4 – Terra de subsolo (TS) + Esterco caprino (EC) (25%:75%) e T5 - Esterco caprino (EC) (100%) com 4 repetições. Foi possível observar pela análise de variância que houve diferença significativa (p<0,05) entre os tratamentos na porcentagem de esterco caprino (EC) para as variáveis germinação (G), altura (H) e diâmetro do colo (DC) aos 30 e 60 dias após a semeadura, massa seca da parte aérea (MSPA) massa seca da parte radicular (MSPR), massa seca total (MST). O T4 proporcionou os melhores resultados nas variáveis analisadas, mesmo assim não é recomendado para a produção de mudas de Anadenanthera peregrina (L) Speg. no tempo avaliado, pois as mesma obtiveram  valor inferior a 0,20 ao qual é recomendado na literatura para o índice de qualidade de Dickson.
QUALIDADE DE VIDA E SATISFAÇÃO NO TRABALHO DE AGENTES COMUNITÁRIOS DE SAÚDE
Authors: Alecrim Cardoso Ana Karoliny
Published: September 2020

Introdução: Agente Comunitário de Saúde (ACS), é o principal agente social da Estratégia de Saúde da Família constituindo o elo entre o serviço e a comunidade, sendo imprescindível nesse cenário. Assim, faz-se necessário avaliar a Qualidade de Vida no Trabalho (QVT) e a Satisfação no Trabalho (ST), visto que possuem relação com a produtividade e alcance dos objetivos organizacionais. Objetivo: avaliar a QVT e a ST dos ACS da região sul de Palmas-TO. Metodos e Materiais: Estudo descritivo, exploratório, quantitativo realizado com 27 ACS dos Centros de Saúde da Comunidade da região sul de Palmas- TO. Utilizou-se o Quality of Working Life Questionnaire - QWLQ-bref e o Questionário de Satisfação no Trabalho S20/S23. Resultados: O escore total médio para QVT foi 3,49, variando de 1,90 a 4,55 e o escore total médio para ST foi 3,40, variando de 1,80 a 5,00. Conclusão: Verificou-se índices elevados de QVT e de ST. Os escores dos domínios da QVT apresentaram correlação positiva moderada ou forte com os fatores da ST, demonstrando na amostra estudada, quanto maior a qualidade de vida no trabalho, maior a satisfação no trabalho.
THE ROLE OF PALM OIL PRICE IN INDONESIA’S AGGREGATE DEMAND
Authors: Sharma Susan Sunila
Published: September 2020

This study examines the predictability of Indonesia’s aggregate demand using palm oil price. We conduct both in-sample and out-of-sample forecasting evaluations. These evaluations are based on time-series quarterly and monthly data frequencies and cover three different forecasting horizons. Overall, we find that palm oil price predicts real GDP, consumption expenditure, total investment, net spending from overseas, while predictability of government spending is sensitive to the use of forecasting approaches and horizons.
The Impact of Legalization of Access to Recreational Cannabis on Canadian Medical Users with Cancer.
Authors: Hawley Philippa Helen , Gobbo Monica , Afghari Narsis
Published: September 2020

Background Canada legalized cannabis use for medical purposes in 1999. Legalization of cannabis for recreational purposes in October 2018 offered the opportunity to assess the impact of recreational legalization on cancer patients’ patterns of use to identify learning points that could be helpful to other countries considering similar legislation.Method Two identical anonymous cross-sectional surveys were administered to cancer patients in British Columbia (2 months before and 3 months following legalization), with the same eligibility criteria. The prevalence of medical cannabis use, the distribution of symptoms leading to use, the most common types of cannabis products and sources, reasons for stopping using cannabis, and barriers to access were assessed.Results The overall response rate was 27%. Both cohorts were similar regarding age (median= 66yrs), gender (53% female), and education (approximately 85% of participants had an education level of high school graduation and higher). Respondents had multiple motives for taking cannabis, including to manage multiple symptoms, to treat cancer, and for recreational reasons. The majority of patients in both surveys did not use the legal medical access system. Comparison of the two cohorts showed that after legalization the prevalence of current cannabis use increased by 26% (23·1% to 29·1%, p-value 0·01), including an increased disclosure of recreational motive for use, from 32% to 40%. However, in the post-legalization cohort more Current Users reported problems getting cannabis (18%) than the pre-legalization cohort (8%), (p-value <0·01). The most common barrier cited was lack of available preferred products, including edibles, as these were only available from illegal dispensaries.Conclusions Results showed that legalization of cannabis for recreational purposes may have an impact on those who use medical cannabis. Impacts include an increase in prevalence of use; problems accessing preferred products legally; higher cost, and difficulties using a legal access system. The desired goal of regulation in reducing harms from use of illegal cannabis products are unlikely to be achieved if the legal process is less attractive to patients than use of illegal sources.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in silico whole genome subtraction.
Authors: Dissanayake Duminda Sampath Bandara , Holleley Clare Ellen , Hill Laura Kate , O’Meally Denis , Deakin Janine Eileen , Georges Arthur
Published: September 2020

Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential influence on the sexes and sequence divergence on the hemizygous homolog. Divergence in the non-recombining regions leads to the accumulation of Y or W specific sequence useful for developing sex-linked markers. Here we use in silico whole-genome subtraction to identify putative sex-linked sequences in the scincid lizard Bassiana duperreyi which has heteromorphic XY sex chromosomes. Results: We generated 96.7 x 109 150 bp paired-end genomic sequence reads from a XY male and 81.4 x 109 paired-end reads from an XX female for in silico whole genome subtraction to yield Y enriched contigs. We identified 7 reliable markers which were validated as Y chromosome specific by polymerase chain reaction (PCR) against a panel of 20 males and 20 females. Conclusions: The sex of B. duperreyi can be reversed by low temperatures (XX genotype reversed to a male phenotype). We have developed sex-specific markers to identify the underlying genotypic sex and its concordance or discordance with phenotypic sex in wild populations of B. duperreyi. Our pipeline can be applied to isolate Y or W chromosome-specific sequences of any organism and is not restricted to sequence residing within single-copy genes. This study greatly improves our knowledge of the Y chromosome in B. duperreyi and will enhance future studies of reptile sex determination and sex chromosome evolution.
Cannabis against chronic musculoskeletal pain: A scoping review on users and their perceptions
Authors: Furrer Daniela , Kröger Edeltraut , Marcotte Martine , Jauvin Nathalie , Bélanger Richard , Ware Mark , Foldes-Busque Guillaume , Aubin Michèle , Pluye Pierre , Dionne Clermont E.
Published: September 2020

Background Chronic musculoskeletal pain (CMP) may lead to reduced physical function and is the most common cause of chronic non cancer pain. Currently, the pharmacotherapeutic options against CMP are limited and frequently consist of pain management with non-steroidal anti-inflammatories, gabapentinoids or opioids, which carry major adverse effects. Although the effectiveness of medical cannabis (MC) for CMP still lacks solid evidence, several patients suffering from it are exploring this therapeutic option with their physicians.Objectives Little is known about MC users suffering from CMP. We aimed to increase this knowledge, useful for health care professionals and patients considering this treatment, as well as for researchers planning rigorous randomized clinical trials on the effectiveness of MC.Methods We conducted a scoping literature review, according to the methods developed by Arksey and O’Malley, to describe the views and perceptions of adult patients who had consumed MC to relieve chronic CMP. The review includes patients’ perceptions on MC against other non-cancer pain since most of the literature reports on both, as well as their demographic characteristics, patterns of MC use, and perceived positive and negative effects.Results Participants of the 49 included studies reported that MC use helped them to reduce CMP and other chronic non-cancer pain, with only minor adverse effects, and some reported improved psychological well-being.Where MC was legally available, persistent users were frequently young or middle-aged men, and the preferred form of use was smoking. The information from these studies has several methodological limitations and results are exploratory.Conclusion MC users suffering from CMP or other chronic non-cancer pain, perceived more benefits than harms. However, these user reported experiences must be examined by well-designed and methodologically sound clinical or observational studies, particularly regarding CMP, since reports on CMP are very scarce.
Transgenerational effect of drug-mediated inhibition of LSD1 on eye pigment expression in Drosophila
Authors: Hoyer-Fender Sigrid
Published: September 2020

Background: The Drosophila melanogaster mutant white-mottled is a well-established model for position-effect variegation (PEV). Transposition of the euchromatic white gene into the vicinity of the pericentric heterochromatin caused variegated expression of white due to heterochromatin spreading. The establishment of the euchromatin-heterochromatin boundary and spreading of silencing is regulated by mutually exclusive histone modifications, i.e. the methylations of histone H3 at lysine 9 and lysine 4. Demethylation of H3K4, catalysed by lysine-specific demethylase LSD1, is required for subsequent methylation of H3K9 to establish heterochromatin. LSD1 is therefore essential for heterochromatin formation and spreading. We asked whether drug-mediated inhibition of LSD affects the expression of white and if this induced change can be transmitted to those generations that have never been exposed to the triggering signal, i.e. transgenerational epigenetic inheritance.Results: We used the lysine-specific demethylase 1 (LSD1)-inhibitor Tranylcypromine to investigate its effect on eye colour expression in consecutive generations by feeding the parental and F1 generations of the Drosophila melanogaster mutant white-mottled. Quantitative Western blotting revealed that Tranylcypromine inhibits H3K4-demethylation both in vitro in S2 cells as well as in embryos when used as feeding additive. Eye colour expression in male flies was determined by optical measurement of pigment extracts and qRT-PCR of white gene expression. Flies raised in the presence of Tranylcypromine and its solvent DMSO showed increased eye pigment expression. Beyond that, eye pigment expression was also affected in consecutive generations including F3, which is the first generation without contact with the inhibitor. Conclusions: Our results show that feeding of Tranylcypromine and DMSO caused desilencing of white in treated flies of generation F1. Consecutive generations, raised on standard food without further supplements, are also affected by the drug-induced alteration of histone modifications. Although eye pigment expression eventually returned to the basal state, the observed long-lasting effect points to a memory capacity of previous epigenomes. Furthermore, our results indicate that food compounds potentially affect chromatin modification and hence gene expression and that the alteration is putatively inherited not only parentally but transgenerationally.
Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study
Authors: Kaze Francois Folefack , Nguefack Seraphin , Asong Constantine Menkoh , Assob Jules Clement Nguedia , Nansseu Jobert Richie , Kowo Mathurin Pierre , Nzana Victorine , Kalla Ginette Claude Mireille , Halle Marie Patrice
Published: September 2020

Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children.Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.
Adolescents Nutritional Status and its association with Academic Performance in South Ethiopia; a facility-based cross-sectional study
Authors: Katiso Selamawit Woldeyohanes , Kerbo Amene Abebe , Dake Samson Kastro
Published: September 2020

Background: Though evidence about the magnitude of malnutrition is well established in Ethiopia, the evidence is scarce about the association of nutritional status with academic performance among adolescents. Thus, this study aimed at determining the association of nutritional status with academic performance among adolescents attending secondary schools in Wolaita Sodo town, Southern Ethiopia.Methods: A facility-based cross-sectional study was conducted among 670 systematically selected adolescents in secondary schools of Wolaita Sodo town from April to June 2019. The academic performance of the adolescents was measured using the average mark score of two consecutive semester's results of the overall subjects. Data were analyzed with STATA software Version 15. Descriptive statistics, Pearson Correlation, and linear regression were used in the statistical analysis. A p-value <0.05 was considered as statistically significant.Results: The mean academic performance of students was 69.21±0.42 (95% CI: 68.34%-70.02%). An average mark score of students increased by 1.89 (β=1.89; 95 %CI: 1.14, 2.64) for a unit increase in BMI for age z-score. Being female decreased an average mark score by 2.63 (β=-2.63; 95 %CI: -4.28, -0.98) and being from a separated parents decreased by 4.73 (β=-4. 73; 95 %CI: -6.73, -2.74). An average mark score of students from the lowest wealth class decreased by 9.92(-9.92; 95 %CI: -12.79, -7.04) as compared to students from the highest wealth class. Attending private schools increased the average mark score of students by 4.18 (β=4.18; 95 %CI: 2.46, 5.90). Conclusion: This study has ascertained that poor academic performance was reported among undernourished students, girls, students whose parents were separated, students of low wealth status households, and students enrolled to public schools. Launching nutritional interventions, household income generating activities targeting lowest wealth status households, and giving tutorial classes for female students were recommended.
Craniofacial morphology/phenotypes influence on mandibular range of movement in the design of a mandibular advancement device
Authors: Sanz Pedro Mayoral , Reyes Mariano Garcia , Torras Alex Bataller , Castillo JA Cabrera , Lagravere Manuel
Published: September 2020

Background. The mandibular opening path movements have different directions according to the craniofacial morphology of the patient but always downward and backward, therefore increasing the collapse of the upper airway. The aim of this work is to determine if there is a relationship between the craniofacial morphology and the mandibular movement to help understand the impact on the mandibular position. Methods. 52 students with full permanent dentition aged 19 to 23 years (mean 21.3 SD 1.7; 29 females and 23 males), participated in the study. Each subject had a lateral cephalometric radiograph taken. The opening angle was determined for two levels of vertical openings at 5 and 10 mm. Results. The opening angle showed a greater variability between subjects ranging from 63,15 to 77,08 for 5 mm angle and from for 61,65 to 75,72 for the 10 mm angle. Differences of facial phenotypes was evident when comparing the individual dissoccluding angle of the low angle horizontal pattern and high angle vertical pattern. Conclusions. The opening angle is related to craniofacial morphology with higher vertical anterior and shorter anteroposterior faces having a more horizontal path of mandibular movement than shorter vertical anterior and longer anteroposterior subjects who have a more vertical path.
Network Pharmacology study of Curcuma longa L.: Potential Target Proteins and their Functional Enrichment Analysis.
Authors: KUMARI SANGEETA
Published: September 2020

Objective This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein-protein interaction network.Results We used target proteins to create protein-protein interaction network (PPIN) and identified significant node and edge attributes of PPIN. We identified the cluster of proteins in the PPIN, which were used to identify enriched pathways. . We identified closeness centrality and jaccard score as most important node and edge attribute of the PPIN respectively. The enriched pathways of various clusters were overlapped suggesting synergistic mechanism of action. The three pathways found to be common among three clusters were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.