bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing a Youth Environmental Stewardship Educational Program by Adopting Logical Framework Approach in Catur Village, Kintamani, Bali
Authors: Susanto Putu Chris , Erfiani Ni Made Diana , Darmawijaya I Putu , Lestari Putu Indah , Pratama I Gede Ngurah Wira
Published: October 2023

Universitas Dhyana Pura (Undhira) has been involved in various research and community empowerment projects in Catur Village, Kintamani, Bangli, Bali. However, no projects in Catur Village have specifically reached the village youths until 2020. Hence, this article discusses developing an empowerment project called the Youth Environmental Stewardship program in Catur Village (YES Catur). Using the Logical Framework Approach (LFA), the authors describe the underlying problem the village youths face, such as a lack of self-efficacy and awareness of micro and macro-environmental issues facing them and their generation. Furthermore, the LFA became the overarching goal of empowering the youths through an environmental stewardship education program, encouraging positive self-view and worldview, the resources and activities designed to engage them, and the intended outputs and outcomes from the project. From this pilot project, the youths are expected to realize their true potential as they appreciate the great natural potential in their village, especially in ecology. They were encouraged to take on active roles in environmental stewardship (including eco-entrepreneurship and circular economy). Finally, they can share about themselves and their village through storytelling and photography to showcase their potential and share about sustainability issues.
The Role of Communities in the Sustainability of Screen-printing Business in Tegal Regency: Case Study on Tegal Screen Printing Community
Authors: Mustofa Rochman Hadi , Utama Refa Putra , Suranto  , Dzikra Noor Syahidah Mutiara
Published: October 2023

This study aims to describe the role of the Tegal T-shirt screen printing community (Tegal Screen Printing) in the t-shirt screen printing business in Tegal and to find out the obstacles faced by screen printing business actors and how to overcome the role of the Tegal T-shirt screen printing community (Tegal Screen Printing) in the t-shirt screen printing business in Tegal. This study employs a qualitative case study methodology. The participants included Tegal Screen Printing's founders, community leaders, and community members. Included among the data collection methods are interviews, observations, and documentation. The validity of the data is carried out by triangulating the source and method. Data collection, reduction, display, and conclusion are the data analysis techniques used. The outcomes demonstrated the community's role as a sharing forum, adding insights related to business ethics, such as communication skills, social skills, and networking; adding insights related to business management, such as leadership, problem-solving, and teamwork; and contributing to the quality of the products produced. There are technical production/technical screen-printing obstacles, e.g., registers and screen clogged either in the design section or the overall design, the difficulty of raw materials, and communities that need to provide counseling on making financial reports. Several options exist for overcoming these obstacles: The Tegal Screen Printing Community also seeks to assist its members with technical matters and scarcity of raw materials in the form of color errors in screen printing with designs, e.g., registers, and obstacles encountered during the film process of screen printing. Additionally, the Community seeks to offer guidance on preparing financial reports.
Primagravida System Usability for Pregnancy and Child Growth Monitoring in Rural Areas
Authors: Lismidiati Wiwin , Kusumawati Happy Indah , Akhmadi  , Lazuardi Lutfan , Sumunar Dimas SEW , Purnama Mia
Published: October 2023

Over the past few decades, medicine and healthcare have significantly improved and decentralized, offering high-quality yet accessible care to individuals. Despite mHealth's substantial role in postpartum and maternity care, the adoption rate in rural and remote areas remains limited in Indonesia. mHealth apps for tracking and monitoring during and after pregnancy can potentially improve both the mother and child’s quality of life. Primagravida is a web-based application introduced for maternal and childcare in a municipality at Kulon Progo Regency, Yogyakarta, Indonesia. A collaborative approach with two primary health care and the local government facilitates expert teams to reach out to pregnant women and parents at risk for health complications. Field supervision sessions were organized to coach targeted populations and voluntary health workers. At the end of the sessions, a System Usability Scale (SUS) questionnaire was distributed to capture users’ experiences. Generally, a SUS score over 68 is considered good [3]. Primagravida application was acceptable and easy to learn among the users. However, the SUS questionnaire was intended as a quick and dirty assessment tool for shallow evaluation. The questions are aimed at identifying possible inconsistencies in the system rapidly. The future study must address more detailed identification with rigorous and comprehensive methods. The study's overall finding is that Primagravida was valued as satisfactory by the targeted audience of users. However, the app's usability is expected to improve through an iterative approach continuously. The findings of this study highlight the connection between efficient health apps and how their layout may foster patient engagement in care delivery. Therefore, developing health apps is essential to introduce an interdisciplinary strategy with early target group participation.
Education of Raja Manta (Gerakan Jajanan Aman dan Sehat) to Promote and Achieve Healthy Indonesia 2025
Authors: Purwestri Yekti Asih , Sari Dini Wahyu Kartika , Nuringtyas Tri Rini , Nilasari Fita
Published: October 2023

The variety of safe and healthy snacks for elementary school students still challenges parents and teachers. The lack of knowledge about safety and healthy snacks among students raises concerns, especially regarding their health. Students often buy delicious snacks that have a flashy color without knowing the safety level of the snacks. Lack of parental and teacher control and the unavailability of school canteen facilities are why students buy snacks randomly. One of the ways to improve awareness for elementary school students is through educational activities related to health and safety snacks. It is essential to deliver educational activities to increase awareness to influence impulsive behavior in choosing healthier and safer snacks. Education of Raja Manta (Gerakan Jajanan Aman dan Sehat/Safe and Healthy Snacks Movement) to promote and achieve Healthy Indonesia 2025 is one of the initiatives to increase awareness regarding selecting healthy and safe snacks for elementary school students. This activity collaborates with SDN Sukosari and SDN Seloharjo, located in Kapanewon Ngaglik, Kalurahan Sukoharjo, Sleman Regency, Daerah Istimewa Yogyakarta. This activity is also in collaboration with Poklasar Usaha Mulia Niki Ulam. Niki Ulam is a Small and Medium Enterprise/Usaha Mikro Kecil dan Menengah (UMKM) that produces healthy food based on processed fish. The educational activity was held indoors, followed by outdoor activities through various educational posts. Indoor activities include interactive education about the function of food for the body, rules for washing hands, and food ingredients, checking expiration dates on food, daily water needs, and proper disposal of food waste. The educational post explains how to distinguish healthy and unhealthy snacks, simple tests on food, make healthy snacks, introduce traditional foods, natural and artificial food dyes, and educational puzzle games for healthy snacks and healthy lifestyles. Through this activity, students learn about healthy and unhealthy snacks, how to choose healthy snacks, and support and promote Healthy Indonesia 2025 by creating a healthy and intelligent young generation.
Keynote Talk: Community Empowerment in Indigenous Resettlement Communities of Southern Taiwan After Typhoon Morakot
Authors: Lin Hui-Nien
Published: October 2023

Typhoon Morakot produced more than 2000 mm of rainfall in two days during August 2009, causing catastrophic damage to parts of southern Taiwan. In the aftermath, 673 people died; 26 went missing; and 1,766 houses were destroyed. To facilitate recovery and reconstruction after the typhoon, the state approved a Special Act of Reconstruction for delimiting specific disaster regions and imposing forced relocation of villagers. A total of 3,096 households, mostly indigenous groups, were relocated to 35 permanent housing units from mountains to lowlands. Without any farmlands, villagers struggled to maintain their livelihoods. In 2020, indigenous villagers protested against the county government for its intention to demolish illegal structures, built by villagers as tourism-related businesses. This advocacy was supported and followed by several university faculty members and NGOs through numerous actions, including organizing protests, filing petitions, and conducting workshops to advocate indigenous human rights. In addition, through university-community collaborations, several “soft actions” were emerged, such as building genealogy and curating settlement history and pictures in local museums, for more community involvement and empowerment. Above all, these advocacy and community actions reflected Sustainable Developments Goals (SDGs) in “climate actions” and “reduced inequalities.” Moreover, through reflections of these actions, community post-disaster resilience may be more about resistance than adaptation. In the future, university scholars and students will continue to work with indigenous communities for advocating indigenous human rights in the era of climate change.
Management accounting methods for financial decisions: Case of industrial companies in Jordan
Authors: Habis Alrawashedh Nahed
Published: October 2023

Management accounting plays a critical role in decision making since it supplies accounting information that would be helpful to managers in making critical decisions for an organization. In light of this assertion, the aim of the study was to determine how the listed Jordanian industrial organizations used management accounting techniques to make financial decisions. The study employed the descriptive research design and used primary data to collect the information on the related objectives of the study. The target population for this study was the employees of industrial enterprises in Jordan. Specifically, the employees forming the part of the sample were the managers and non-managers (excluding lower-level staff) working in industrial companies of Jordan. The industrial firms from where the employees were chosen included the industrial firms listed on the Amman Stock Exchange. The sample size for the study has been 371 employees, selected based on the Krejcie and Morgan rule. The study’s findings supported the notion that budgeting, financial ratio analysis and activity-based costing are the most widely used management accounting techniques in these organizations. The results show that employees differ in their perception on the role of management accounting techniques in financial decision making. Specifically, the results of the study confirm the significant p-value (0.000) for t-statistics and f-value, thereby confirming that employees differ in their perception regarding the role of management accounting in financial decision making based on gender, type of job and years of experience.
Efficacy and safety of ab-externo radiofrequency sclerostomy in management of open-angle glaucoma
Authors: Fathallah M. Abd El Latief , Abdel-Hamid R. M. , Salah S. H. , El-Shiaty A. F. , El-Zawahry O. M.
Published: October 2023

Purpose. To evaluate the efficacy and safety profile of an innovative ab-externo technique in the management of uncontrolled open angle glaucoma (OAG) through creating filtering tracts subconjunctivally.Material and methods. This is a randomized clinical trial including 40 eyes (40 patients) divided into 2 equal groups, group (A), underwent ab-externo radiofrequency sclerostomy and group (B), underwent ab-externo radiofrequency sclerostomy with subconjunctival injection of mitomycin C. Intraoperative and postoperative complications, visual acuity, intraocular pressure (IOP) and bleb status were evaluated for 6 months.Results. The mean preoperative IOP was 28 ± 3.5 mm Hg reduced to 21.9 ± 5.2 mm Hg (p = 0.001) in group (A) and was 29.4 ± 3.4 mm Hg reduced to 20.8 ± 6.3 mm Hg (p = 0.001) in group (B), 6 months postoperatively. Both groups showed a significant percent reduction of IOP 15.1 ± 17.3%, 27.1 ± 22.4% in groups (A) and (B) respectively with group (B) showing lower values on days 1, 7, 14, 30, 90 and 180 but was not statistically significant. The number of anti-glaucoma medications was significantly reduced in both groups. Heat radiation to the cornea from radiofrequency waves was obvious in early cases — 5 (25%) in group (A), and 3 (15%) in group (B) that was reversible within the first 3 months postoperatively. Shallow anterior chamber and choroidal detachment were the most encountered early postoperative complication, which all managed conservatively.Conclusion. Ab-externo radiofrequency sclerostomy offers a promising minimally invasive, quick and simple procedure in management of early and moderate cases of OAG with effective reduction of IOP and number of glaucoma medication.
Keratoprostheses: from the past to the future
Authors: Grishchenko M. V. , Myasnikova V. V. , Nefedov D. A.
Published: October 2023

The review outlines the models of keratoprostheses currently used in various countries and their effectiveness, conceptual models under development, prospects and trends in keratoprosthetics observed in the world.
Medical and technical aspects of using intraocular lenses with extended depth of field
Authors: Konovalov M. E. , Morenko A. V.
Published: October 2023

Purpose: to analyse the medical and technical aspects of intraocular lenses (IOLs) with extended depth of field (EDOF). Literature analysis was performed in the PubMed international database, the search keywords being “IOL with extended depth of field” (EDOF), “Optical Bench Evaluation of IOL”, “Preclinical evaluation of IOL”, “Aberrations”, “Monofocal IOL” (MOFIOL), “Multifocal IOLs” (MUFIOL). A total of 226 sources were analyzed, further using systematic review filters and the authors' knowledge of the topic. The duration of the retrospective analysis was 7 years (2016–2022), some of the considered work dates back to 2023. Unlike MUFIOL, EDOF lenses create a single elongated focal point to increase the depth of field, rather than several foci. Thus, EDOFs are aimed at reducing light phenomena, glare and halos, the occurrence of which is characteristic of MUFIOL. A potential disadvantage of EDOF is the reduction in retinal image quality with an excessive increase in the number of aberrations. The factors of the medical and technical assessment of the IOL indicate a high correlation with the predicted visual acuity (VA). EDOFs, whose design features are based on a higher order aspherical design, provide comparable optical quality for the far and extended intermediate ranges, while producing halo effects comparable to those of MOFIOL. Designed to improve depth of field with a full correction of corneal spherical aberration, EDOF provides intermediate-level pupil-independent improvement in VA and maintains visual acuity unlike conventional MOFIOLs. The quality of visual perception and the predicted VA of various types of EDOFs depend on the optical technology and the correction of corneal spherical aberrations. EDOFs can be expected to provide adequate vision at an intermediate distance (with a possibility of insufficient near vision). At the same time, the expansion of the depth of field varies between models, which should be taken into account when preoperatively choosing EDOF for a specific type of daily visual activity of the patient, especially for people with visually strenuous work. The results of the medical and technical assessment are widely used in the clinical testing of specific types of EDOF IOLs.
Modifying treatment of degenerative retinal diseases. Part 2. Conditioning therapy techniques and the problem of maximizing retinal plasticity
Authors: Neroeva N. V. , Zueva M. V. , Katargina L. A. , Kotelin V. I. , Zhuravleva A. N. , Tsapenko I. V. , Fadeev D. V.
Published: October 2023

In the first part of the review [ROJ, 2023; 16 (2): 160–2], we discussed the common and specific features of adaptive and non-adaptive retinal plasticity characteristic of glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity. The presented part of the review discusses the issues of axon regeneration of retinal ganglion cells and analyzes therapeutic approaches aimed at maximizing the plasticity and stimulating the reparative potential of the retina. The protective effects of "conditioning" stimuli in the modifying treatment of retinal diseases are considered. Some of the present-day visual rehabilitation strategies based on visual perception training and visual fixation training using biofeedback systems are reported.
Diagnostics of retinal pathologies by optical coherence tomography images using artificial intelligence tools
Authors: Neroev V. V. , Bragin A. A. , Zaytseva O. V.
Published: October 2023

The importance of early detection and monitoring of retinal diseases determines the relevance of the study devoted to the diagnosis of retinal pathologies by OCT images using artificial intelligence (AI) tools.The purpose is to develop algorithms for diagnosing retinal pathologies from OCT images by machine learning methods.Material and methods. The study used a dataset (20,000 eyes), publicly available on the Internet, which contains OCT images of healthy retina (5,000 eyes) and retina affected by three different pathologies (choroid neovascularization, macular edema, multiple drusen, 15,000 eyes). The retinal pathology recognition system is based on a trained neural network VGG16 (developed by a visual geometry group of Oxford University).Results. The main result of the research is the development of an algorithm, implemented on Python, for the diagnosis of retinal diseases from OCT images based on convolutional neural network AI tool. The sensitivity and selectiveness of the neural network model during the diagnosis of retinal diseases were 97 and 98%, respectively.Conclusion. AI methods used in the retinal pathology automatic detection system developed at the Helmholtz National Medical Research Center of Eye Diseases as part of automated medical decision-making system have been shown to have high potential and efficiency. In the future, this service can be used to improve the effectiveness of early diagnosis and monitoring of retinal diseases in conditions of reduced availability of primary ophthalmological care in some of the territories of the Russian Federation, including that provided at the pre-doctoral stage.
Suriye Mülteci Kamplarının ve İnsani Yardım Depo Konumlarının Coğrafi Bilgi Sistemi (CBS) ve Doğrusal Programlama ile Modellenmesi
Authors: ATAY Metehan , ALHAMAD Mohamad , ÇETİNKAYA Cihan , SEÇKİNER Serap
Published: October 2023

Tüm dünyada yüzlerce sivil toplum kuruluşu, savaşlar ve afetler nedeniyle ülkelerinden göç etmek zorunda kalan ve kamplarda yaşayan mültecilere destek olmak için çaba göstermektedir. Suriye bu konuda bir örnektir. Suriye'de bulunan sivil toplum kuruluşlarının insani yardım depolarından kamplara gidecek olan malzemelerin lojistiği ise bilinen ve çözümlenebilen bir insani yardım lojistiği problemidir. Bu makalenin amacı, Sivil Toplum Kuruluşlarının (STK) depo alanları için uygun yerleri araştırmaktır. Her insani yardım lojistiği probleminde olduğu gibi belirlenen depo lokasyonlarından nihai kullanıcı ve ihtiyaç sahiplerine ulaştırılması gereken malzemelerin taşıma işlemleri gerçekleştirilirken minimum miktarda maliyet ile maksimum miktarda ürün dağıtımı amaçlanmıştır. Bu çalışma, Doğrusal Programlama (LP) ve Coğrafi Bilgi Sistemi (CBS) kullanılarak tanımlanmış, çözülmüş ve her bir çözüm yönteminin sonuçları arasında bir karşılaştırma gösterilerek maliyet analizleri yapılmıştır.
Analysis of Current Limiting Algorithm with Anti-Windup Control for Transient Stability of Grid-Forming Converters
Authors: ÇELİK Özgür
Published: October 2023

In modern power grids, renewable energy sources (RESs) are integrated to the grid through voltage source converters (VSCs) with grid-forming capabilities. Grid forming VSCs’ weak overcurrent capability revealed the need for current limiting techniques under large disturbances like short-circuit faults. However, current saturation algorithms induce transient instabilities due to the AC voltage controller windup issue when the current is saturated. Therefore, analyzing the transient stability of the grid-forming units in case of fault conditions is crucial for ensuring the reliable and secure operation of the grid. This paper investigates the effects of the current limiting algorithm with anti-windup control to handle transient instabilities during fault conditions. An elaborated theoretical analysis of the presented system is performed by considering different case studies. The simulations are conducted by using Matlab/Simulink software to test the validity of the presented system. The obtained results highlight the advantages of an anti-windup controller during current saturation mode.
Derin Öğrenme Modelleri ve Veri Ön İşleme Yöntemleri ile Çeltik Yaprak Hastalıklarının Erken Teşhisi
Authors: ÖZDEMİR Cüneyt
Published: October 2023

Son yıllarda tarım sektöründe, derin öğrenme temelli bilgisayar destekli sistemler büyük bir önem kazanmış ve farklı uygulama alanlarında etkili bir rol oynamıştır. Bu sistemler sadece hastalıkların erken teşhisine katkı sağlamakla kalmamış, aynı zamanda tarım profesyonellerine önemli bir destek sunmuştur. Bu bağlamda, bu çalışma çeltik yapraklarında mevcut hastalıkların erken teşhisinde derin öğrenme yöntemlerinin etkinliğini araştırmayı amaçlamaktadır. Bu araştırma için, 13 farklı çeltik hastalığına ait toplam 4160 görüntü içeren Paddy Doctor veri kümesi kullanılmıştır. Veri kümesi üzerinde beş farklı transfer öğrenme modeli titizlikle değerlendirilmiştir. Elde edilen sonuçlar, Xception modelinin %93,37'lik doğruluk oranı ile en üstün performansı gösterdiğini açıkça ortaya koymaktadır. Ayrıca, bu çalışma veri ön işleme ve veri artırma tekniklerini optimize etme konusuna da değinerek veri kümesini zenginleştirmeyi ve teşhis doğruluğunu artırmayı amaçlamıştır. Başarılı bulunan modelin çeltik yaprak hastalıklarını teşhis etmedeki performansı ayrıntılı bir şekilde değerlendirilmiştir. Bu değerlendirme sonucunda, modelin en başarılı olduğu hastalık sınıfları belirlenmiş ve aynı şekilde modelin en zorlandığı veya en düşük doğruluk oranına sahip hastalık sınıfları da tespit edilmiştir. Bu bulgular, çeltik hastalıklarının erken teşhisinde transfer öğrenme modellerinin potansiyelini vurgulayarak tarım sektöründe etkili otomatik teşhis sistemlerinin geliştirilmesine olanak tanımaktadır. Bu yaklaşım, tarım sektöründe mahsul verimini artırma ve pestisit kullanımını azaltma yolunda umut vadetmektedir. Ayrıca, daha sağlıklı ve sürdürülebilir tarım uygulamalarını teşvik etme odaklı bu araştırma, gelecekteki stratejilere de katkı sağlayabilir.
EYM ile Üretilen YMK Yapılı Numunelerde Kenar Genişliğinin Basma Dayanımı Üzerine Etkisinin Araştırılması
Authors: TUNÇEL Oğuz , TUTAR Mumin
Published: October 2023

Bu çalışmada, 3 boyutlu baskı (3D printing) kullanılarak üretilen farklı kenar genişliklerine sahip yüzey merkezli kübik YMK yapılı numunelerin basma dayanımı üzerindeki etkisi incelenmiştir. PLA malzemesi kullanılarak Eriyik Yığma Modellemesi (EYM) yöntemi ile numuneler üretilmiştir. Kenar genişliği arttıkça, maksimum basma yüklerinde ve basma dayanımlarında artışlar gözlenmiştir. En düşük yük 1,2 mm kenar genişliğinde 2849 N iken, en yüksek yük 2,4 mm kenar genişliğinde 6351 N olarak ölçülmüştür. Benzer şekilde, en düşük basma gerilimi 34,76 MPa ile 1,2 mm kenar genişliğinde, en yüksek basma gerilimi ise 40,15 MPa ile 2,4 mm kenar genişliğinde kaydedilmiştir. Kenar genişliğinin artmasıyla birlikte maksimum yük/kütle değeri %33,1 oranında artış göstermiştir. Sonuçlar, 3D baskı üretiminde kenar genişliğinin tasarım faktörü olarak önemini vurgularken, daha geniş kenar genişliklerinin ürünlerin mekanik dayanıklılığını artırabileceğini ve uygulama gereksinimlerine uygunluğunu sağlayabileceğini göstermiştir.
Spatiotemporal rainfall variability and its relationship to flash flood risk in Northeastern Sylhet Haor of Bangladesh
Authors: Akter Nurunnaher , Islam Md. Rafiqul , Karim Md. Abdul , Miah Md. Giashuddin , Rahman Md. Mizanur
Published: October 2023

The variability and distribution of rainfall are uniquely significant for climatic risk prediction. This study aims to assess spatiotemporal rainfall variability and flash flood intensity events in the Sylhet haor region of Bangladesh by analyzing rainfall data from April for the period 1995–2022. For this, we used both Climate Hazards Group InfraRed Precipitation with Station (CHIRPS) data and Bangladesh Meteorological Department (BMD) daily rainfall data. Rainfall patterns were studied using zonal statistics in ArcGIS and graphical illustration. The results revealed that the rainfall pattern was erratic and showed a range of spatiotemporal variability. If the average rainfall exceeds 250 mm in Meghalaya and Assam and 400 mm in Sylhet, severe flash floods may occur in the Sylhet haor region. An increase in pre-monsoon rainfall and its shift from May to April may increase the intensity of flash floods and consequently damage the rice crop. This finding might help flood management agencies to develop flood management strategies, prepare flood contingency plans, provide real-time and advanced warnings to strengthen flood warning and forecasting systems, and schedule seasonal agricultural activities.
Ortaöğretim Öğrencilerinin Acil Durum Uzaktan Öğretime Yönelik Tutumları, Dijital Vatandaşlıkları ve Deneyimlerinin İncelenmesi
Authors: KIYMET Çağlar , ÇAKIR Recep
Published: October 2023

Bu çalışmanın amacı; ortaöğretimdeki öğrencilerin uzaktan eğitime yönelik tutumları ile dijital yeterlilikleri arasındaki ilişkiyi incelemek ve salgın sürecinde yürütülen derslerle ilgili öğrencilerin görüşleri analiz edilerek sürecin verimliliğini ortaya koymaktır. Çalışma, karma yöntem araştırması ile yürütülmüştür. Çalışmanın örneklemini Amasya ilinde farklı liselerdeki 689 öğrenci oluşturmuştur. Nitel veriler için 10 öğrenci ile görüşmeler yapılmıştır. Nicel veriler öğrencilerden “E-öğrenmeye Yönelik Tutum Ölçeği” ve “Gençlere Yönelik Dijital Vatandaşlık Ölçeği” ile toplanmıştır. Yarı yapılandırılmış görüşme formu ile nitel veriler toplanmıştır. Çalışma sonuçlarına göre; öğrencilerin eöğrenmeye yönelik tutumları ve dijital vatandaşlıkları orta seviyededir. Öğrencilerin cinsiyete göre e-öğrenmeye yönelik tutumları anlamlı bir farklılık göstermekte, dijital vatandaşlıkları ise anlamlı bir farklılık göstermemektedir. E-öğrenmeye yönelik tutumları ve dijital vatandaşlıkları sınıf düzeylerine göre anlamlıdır. Öğrencilerin e-öğrenmeye yönelik tutumları ile dijital vatandaşlıkları arasında pozitif yönde ve anlamlı bir ilişki bulunmaktadır. Öğrencilerin dijital vatandaşlıkları, e-öğrenmeye yönelik tutumlarını anlamlı bir şekilde yordamaktadır. Nitel veriler içerik analiziyle çözümlenmiştir. Uzaktan eğitimle yapılan dersler fırsat eşitsizliğine ve sınıf yönetiminde zorluğa sebep olurken, mekândan ve zamandan bağımsız olunmasını sağlamaktadır. Uzaktan eğitim ile yürütülen derslerin kalitesinin arttırılması için öğrencilerin görüşleri doğrultusunda çalışmada sunulan önerilerle ortaöğretimde yaşanan olumsuzlukların önüne geçilmesi amaçlanmıştır.
Friedrich Hölderlin or Emanuele Severino? The Sacral Dimension of Nature in the Context of Modern Technology
Authors: Kobylinski Andrzej
Published: October 2023

The main purpose of inquiries undertaken in this study is to present a synthesis of the views of the German poet Friedrich Hölderlin and the Italian thinker Emanuel Severino on nature and technology, and to analyze the contemporary manifestations of the re-sacralization of nature in many ecological currents, as discussed in her studies by the French philosopher Chantal Delsol. For Hölderlin, nature is never limited to being an empirical object of scientific investigation. It is a divine reality that does not undergo change. It is a space inhabited by the sacred. Nature constitutes the sacred All, beyond which nothing else exists. Severino, in turn, analyzes the impact of modern technology on nature, man and the entire existing world. He believes science and modern technology have become an extremely effective tool of man’s dominion over the natural world. The Italian philosopher says that today the human will to power applied to nature leads to its objectification and desacralization. Delsol, on the other hand, points out that throughout Western culture we are now witnessing the birth of a new religion of nature, which is a modern form of ancient paganism. The analyses performed demonstrate that, on the one hand, nature is currently being subjected to profound changes due to science and technology, while on the other – its former sacral character is being restored, forming the foundation of a new form of religiosity.
Bioisosteric Replacement through 1,2,3-triazolyl Linkage Significantly Potentiate
Biological Activity in Lidocaine and Etidocaine Analogs: Rational Design and Local
Anesthetic Activity
Authors: Sahu Adarsh , Agrawal Ram Kishore
Published: October 2023

Cytochrome P450 3A4, the most abundant form of isoenzyme, in combination
with several other isoforms, metabolizes lignocaine into mono-ethylglycine xylidide
(MEGX) and glycylxylidide (GX), through N-dealkylation, ring hydroxylation, amide
cleavage, and conjugation process which contribute the toxic effects. Inspiring by the rationality,
functional approaches, and predictable facts lay by the emerging research groups,
we were unquestionably fascinated by the rational development of novel lignocaine and
etidocaine compounds, which are highly metabolically stable by applying non-classical
bioisosteric principles. Distinctively, we have investigated the efficacy of 1,4-
disubstituted-1,2,3-triazoles as metabolically stable trans-amide bond mimics. The 1,2,3-
triazoles have been described in the literature as amide bond bioisosteres, which are analogous
in stipulations of size, planarity, hydrogen bonding properties, and dipole moment. The systematic replacement
of the single amide bonds by the 1,2,3-triazole heterocycle in the backbone of the peptide, often
termed a “triazole scan,” provided several stabilized analogs with marked improved in-vivo local anesthetic
properties. The analogs were synthesized using azide-alkyne cycloaddition. The 2a-b was coupled with aromatic
and aliphatic alkynes using click chemistry in the presence of copper sulfate pentahydrate and L-sodium
ascorbate in a Fritsch ball mill under solvent-free conditions at 300 rpm, furnishing the conjugates 4a-n in 80-
85% yields. The study perceptively opened new avenues of systematic replacement of the single amide bonds
by the 1,2,3-triazole heterocycle in the backbone of the peptide, thereby providing several stabilized analogs
with marked improved in-vivo local anesthetic properties. The best active candidates 4a, 4b and 4g produced
analogous local anesthetic activity with that of the lignocaine.
Lipase Catalyzed Synthesis of D-xylose-based Biosurfactants and their Surface
Properties
Authors: Loulou Fatma , Bidjou-Haiour Chahra
Published: October 2023

Synthesis of a homologous series of 1-O-acyl xylose esters with long and very long
acyl chains derived from fatty acids was performed via enzymatic esterification in one step using
Candida antarctica lipase B. The effect of fatty acid chain length on the activity of the lipase
was evaluated. Subsequently, the surface properties of the obtained products have been determined
such as hydrophilic-lipophilic balance, critical micellar concentration, and surfactant
packing parameter. Foaming and emulsifying ability were also measured. The highest conversion
was obtained by using docosanoic acid as an acylant agent (67.50 %). The surface tension
values are between 25 mN.m-1 for 1-O-octadecanoyl-D-xylopyranose and 47,17 mN.m-1 for
1-O-docosanoyl-D-xylopyranose. The emulsifying abilities of all esters exceeded 80%. It was
found that the surface properties of the surfactants are greatly affected by the fatty acid chain length. The surface
parameters results revealed that the prepared compounds have a good surface activity. Additionally, these
bio-surfactants display good emulsifying ability.
Oligomers Electrosynthesis: A Selective and Greener Synthetic Tool
Authors: Scarano Vincenzo , Mattiello Leonardo , Rocco Daniele
Published: October 2023

Oligomeric compounds can be considered from two points of view: polymer chemistry
often sees them as undesired by-products of polymerization processes or, more fruitfully, synthesizes
them as structural models for polymers, while organic chemistry synthesizes oligomers,
with a typical bottom-up approach, starting from the respective monomers. Conjugated oligomers
play a fundamental role in the field of organic semiconductors and therefore in the field of
industrial and high-tech applications. Electrochemistry can make a significant contribution to
the field of oligomers by rendering the syntheses more expeditious in comparison with the classical
organic ones. The electrochemical approach may offer several advantages over the traditional
organic synthesis. For example, cleaner and more sustainable syntheses and simpler and
shorter synthetic pathways. This review outlines the application of electrochemistry techniques
in the synthesis of oligomers.
A Concise Review of Carbon Dots and their Pharmaceutical and Biomedical Applications
Authors: Parashar Ashish Kumar , Verma Krishna Kumar , Kumar Rajeev , Arora Vandana
Published: October 2023

For the last two decades, carbon dots, a revolutionary type of carbon nanomaterial with
less than 10 nm diameter, have attracted considerable research interest. CDs exhibit various physicochemical
properties and favorable characteristics, including excellent water solubility, unique optical
properties, low cost, eco-friendliness, an abundance of reactive surface groups, and high stability.
As a result, the synthesis of CDs and their applications in pharmaceutical and related disciplines
have received increasing interest. Since CDs are biocompatible and biodegradable with low toxicity,
they are a promising healthcare tool. CDs are extensively employed for numerous applications to
date, including theranostics, bioimaging, drug delivery, biosensing, gene delivery, cancer therapy,
electrochemical biosensing, and inflammatory treatment. This comprehensive review aims to explore
various synthesis methods of carbon dots, including top-down and bottom-up approaches, as
well as highlight the characterization techniques employed to assess their physicochemical and biological
properties. Additionally, the review delves into carbon dots' pharmaceutical and biomedical
applications, showcasing their potential in drug delivery, bioimaging, diagnostics, and therapeutics.
Pengaruh Pemberian Minyak Ikan Lemuru Terhadap Kadar Glukosa Darah Puasa Pada Tikus Wistar Hiperglikemia
Authors: Caressa Dea Amanda , Adi Annis Catur , Adiningsih Sri , Purwoto Septyaningrum Putri , Pranoto Adi
Published: October 2023

Penelitian ini bertujuan menganalisis efek pemberian minyak ikan lemuru terhadap penurunan kadar glukosa darah puasa pada tikus dengan hiperglikemia. Penelitian ini merupakan experimental laboratories dengan racangan The Randomized Post Test Only Control Group Design. Sampel penelitian ini adalah 25 ekor tikus jenis Rattus Norvegicus Strain Wistar jantan, usia 2-3 bulan yang dibagi menjadi lima kelompok. Teknik analisis data menggunakan uji one-way ANOVA dan Tukey HSD. Pada uji one-way ANOVA diadaptkan nilai P (0,001) < 0.05. Hasil Tukey HSD didapatkan rata-rata kadar GDP antara K0 dengan K1 (P < 0,005), P1 dengan K1 (P < 0,005), P2 dengan K1 (P < 0,005), P3 dengan K1 (P < 0,005), sedangkan K0 dengan P1, K0 dengan P2, K0 dengan P3, P1 dengan P2, P1 dengan P3, dan P2 dengan P3 tidak menunjukkan perbedaan signifikan (P > 0,05). Berdasarkan hasil penelitian disimpulkan bahwa terdapat perbedaan pengaruh yang signifikan pemberian minyak ikan lemuru (sardinella lemuru) terhadap kadar glukosa darah puasa. Terdapat perbedaan yang signifikan antara K0 dengan K1, P1 dengan K1, P2 dengan K1, P3 dengan K1, sedangkan K0 dengan P1, K0 dengan P2, K0 dengan P3, P1 dengan P2, P1 dengan P3, dan P2 dengan P3 tidak menunjukkan perbedaan yang signifikan.
RETROSPECTIVE ANALYSIS OF THE CLINICAL AND ANAMNESTIC FEATURES OF PATIENTS WITH INFERTILITY AND FAILED IVF ATTEMPTS IN THE ANAMNESIS ON THE BACKGROUND OF UTERINE LEIOMYOMA AND CHRONIC ENDOMETRITIS
Authors: Khmil S.V. , Petryshyn N.Ya.
Published: October 2023

Резюме. Мета. Провести порівняльний аналіз клініко-анамнестичної картини пацієнток із безпліддям та невдалими спробами ЕКЗ в анамнезі при коморбідності лейоміоми матки та хронічного ендометриту.
Матеріали та методи. Проведено ретроспективний аналіз амбулаторних карток 130 пацієнток з безпліддям. Для проведення аналізу пацієнток розділили на три клінічні групи.  Першу групу дослідження склали 47 жінок із невдалими спробами ЕКЗ та лейоміомою матки, другу – 53 жінки із безпліддям на тлі лейоміоми матки та хронічного ендометриту (у пацієнток цієї групи також наявні невдалі спроби ЕКЗ в анамнезі). Третю (контрольну) групу порівняння склало 30 пацієнток із безпліддям, обумовленим чоловічим фактором.
Результати. Клініко-анамнестична картина жінок з лейоміомою матки та хронічним ендометритом характеризується порушеннями репродуктивної функції. Найчастіші скарги включають зміну характеру та ритму менструації, в тому числі аномальні маткові кровотечі, звичне невиношування, безпліддя, синдром хронічного тазового болю, в тому числі диспареунія, та білі із статевих шляхів. Дані вказують на збільшену частоту урогенітальних інфекцій та більшу кількість перенесених оперативних втручань як факторів розвитку ХЕ та ЛМ. Аналіз анамнестичних даних жінок з ЛМ та ХЕ встановив превалювання вторинної форми безпліддя та наявність попереднього його лікування, в тому числі за допомогою ДРТ. Невдалі спроби ЕКЗ зафіксовано у всіх групах, включених в дослідження. Кількість проведених стимуляцій овуляції в протоколах ЕКЗ коливалась від 1 до 3, а спроб ембріотрансферу у цих же пацієнток – від 2 до 5.
Висновки. Отримані результати ретроспективного аналізу вказують на характерні клініко-анамнестичні особливості у пацієнток із безпліддям на тлі коморбідності лейоміоми матки та хронічного ендометриту. Наявність в анамнезі невдалих спроб ЕКЗ обгрунтовують подальший науковий пошук для оптимізації тактики ведення таких пацієнток в програмах допоміжних репродуктивних технологій.
MULTIPLE HEMANGIOMAS ON THE HEAD OF THE PENIS
Authors: Voloshynovych M.S. , Tkach V.Ye. , Girnyk G.Ye. , Matkovska N.R. , Voloshynovych V.M. , Kozak N.V.
Published: October 2023

Вступ. Гемангіоми є доброякісними судинними мальформаціями, що складаються зі збільшених, звивистих, диспластичних судинних камер. Клінічно виглядають як блакитні м’які судинні маси. Викликають такі симптоми, як біль, тяжкість, набряк, виразка, кровотеча та тромбоз.
Можуть бути локалізовані по всьому тілу, проте рідко зустрічаються на геніталіях. В загальній структурі гемангіом частка утворів такої локалізації складає лише 1-2%. к правило пацієнти звертаються за допомогою у випадку гемангіом значного розміру, тоді як дрібні утворення залишаються поза увагою до моменту їх зростання.
Презентація випадку. В публікації описано клінічний випадок множинних дрібних гемангіом на головці статевого члена у хворого А. 34-ох років. Виявлені під час профілактичного огляду. Зважаючи на розмір висипань, для уточнення діагнозу використана дермоскопія. На фоні типових, для слизової оболонки, судинних структур, та дифузної пігментації, визначаються множинні, різного розміру, переважно округлої форми, синього-блакитного кольору глобули, що розташовані на різній глибині. Також поміж дифузно розсіяних ретикулярних судин поодиноко спостерігаються значно розширені, неправильної форми судинні резервуари, що ймовірно являють проміжну стадію перед трансформацією в судинні глобули. Описана картина відповідає множинним гемангіомам.
Висновки. Завдяки застосуванню дермоскопії гемангіоми діагностовані на етапі, коли зважаючи на розмір елементів та їх розповсюдженість використання хірургічного лікування недоцільне. Пацієнту рекомендовано застовування судинного лазера для видалення окремих гемангіом, що змінюють рельєф поверхні головки статевого члена та чинять дискомфорт, та наступне динамічне спостереження.
PLANEJAMENTO NAS AULAS DE EDUCAÇÃO FÍSICA ESCOLAR
Authors: Carvalho Gilianne dos Santos , Araújo Beatriz Lima de , Costa Fábio Soares da
Published: October 2023

A Educação Física Escolar ainda possui muitos desafios de legitimação na escola, dos quais a construção de um planejamento inclusivo é objeto deste estudo. O objetivo foi analisar as relações que a construção do planejamento pedagógico das aulas de Educação Física estabelece com a estrutura física, o material pedagógico, as propostas curriculares e o desenvolvimento curricular nacional e local. É uma pesquisa quanti-qualitativa que investigou 11 professore(a)s em 09 escolas de Teresina-PI. A Análise de Conteúdo Categorial das narrativas docentes fundamentou a construção de quatro categorias e a conclusão de que mesmo diante das dificuldades como a escassez de materiais pedagógicos e a insuficiente estrutura física, a cultura do planejamento inclusivo vem crescendo, fato que tem resultado em ações pedagógicas com aulas mais significativas na vida dos escolares e estratégias são elaboradas para tornar as atividades corporais mais inclusivas.
Knowledge Sharing and Patient Choice: Exploring the Curvilinear and Moderated Relationships in the Online Health Community (Preprint)
Authors: Zhang Pengfei , Chen Min , Yin Yishuai
Published: October 2023

BACKGROUND

An increasing number of patients are opting to utilize online health communities as their access to healthcare. However, there is limited research on the factors influencing patient choice in online health communities.

OBJECTIVE

The aim of this study was to explore the impact of physicians' knowledge-sharing in online health communities on patient choice and to analyze the potential theoretical boundaries of the relationship.

METHODS

This study used data collected from a large online health community in China for empirical analysis to illustrate a nonlinear relationship between physicians' knowledge-sharing and patients’ choices.

RESULTS

There was an inverted U-shaped relationship between physicians' knowledge-sharing and patients' choices. Moreover, the physician's pricing marked the non-linear relationship even steeper.

CONCLUSIONS

This research serves to enrich the existing literature concerning determinants of patient choice by investigating the nonlinear impact of physicians’ knowledge-sharing. This study has important practical implications for improving the quality of online healthcare services and the doctor-patient relationship.
Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial (Preprint)
Authors: Leung Nicholas , Waki Kayo , Nozoe Satoshi , Enomoto Shunpei , Saito Ryo , Hamagami Sakurako , Yamauchi Toshimasa , Nangaku Masaomi , Ohe Kazuhiko , Onishi Yukiko
Published: October 2023

BACKGROUND

Lifestyle modifications are a key part of type 2 diabetes mellitus treatment. Many patients find long-term self-management difficult, and mobile apps could be a solution. In 2010, in the United States, a mobile app was approved as an official medical device. Similar apps have entered the Japanese market but are yet to be classified as medical devices.

OBJECTIVE

The objective of this study was to determine the efficacy of Save Medical Corporation (SMC)–01, a mobile app for the support of lifestyle modifications among Japanese patients with type 2 diabetes mellitus.

METHODS

This was a 24-week multi-institutional, prospective randomized controlled trial. The intervention group received SMC-01, an app with functions allowing patients to record data and receive personalized feedback to encourage a healthier lifestyle. The control group used paper journals for diabetes self-management. The primary outcome was the between-group difference in change in hemoglobin A1c from baseline to week 12.

RESULTS

The change in hemoglobin A1c from baseline to week 12 was –0.05% (95% CI –0.14% to 0.04%) in the intervention group and 0.06% (95% CI –0.04% to 0.15%) in the control group. The between-group difference in change was –0.11% (95% CI –0.24% to 0.03%; P=.11).

CONCLUSIONS

There was no statistically significant change in glycemic control. The lack of change could be due to SMC-01 insufficiently inducing behavior change, absence of screening for patients who have high intention to change their lifestyle, low effective usage of SMC-01 due to design issues, or problems with the SMC-01 intervention. Future efforts should focus on these issues in the early phase of developing interventions.

CLINICALTRIAL

Japan Registry of Clinical Trials jRCT2032200033; https://jrct.niph.go.jp/latest-detail/jRCT2032200033
Performance of ChatGPT on Nephrology Test Questions
Authors: Miao Jing , Thongprayoon Charat , Garcia Valencia Oscar A. , Krisanapan Pajaree , Sheikh Mohammad S. , Davis Paul W. , Mekraksakit Poemlarp , Suarez Maria Gonzalez , Craici Iasmina M. , Cheungpasitporn Wisit
Published: October 2023

Background

ChatGPT is a novel tool that allows people to engage in conversations with an advanced machine learning model. ChatGPT's performance in the US Medical Licensing Examination is comparable with a successful candidate's performance. However, its performance in the nephrology field remains undetermined. This study assessed ChatGPT's capabilities in answering nephrology test questions.

Methods

Questions sourced from Nephrology Self-Assessment Program and Kidney Self-Assessment Program were used, each with multiple-choice single-answer questions. Questions containing visual elements were excluded. Each question bank was run twice using GPT-3.5 and GPT-4. Total accuracy rate, defined as the percentage of correct answers obtained by ChatGPT in either the first or second run, and the total concordance, defined as the percentage of identical answers provided by ChatGPT during both runs, regardless of their correctness, were used to assess its performance.

Results

A comprehensive assessment was conducted on a set of 975 questions, comprising 508 questions from Nephrology Self-Assessment Program and 467 from Kidney Self-Assessment Program. GPT-3.5 resulted in a total accuracy rate of 51%. Notably, the employment of Nephrology Self-Assessment Program yielded a higher accuracy rate compared with Kidney Self-Assessment Program (58% versus 44%; P < 0.001). The total concordance rate across all questions was 78%, with correct answers exhibiting a higher concordance rate (84%) compared with incorrect answers (73%) (P < 0.001). When examining various nephrology subfields, the total accuracy rates were relatively lower in electrolyte and acid-base disorder, glomerular disease, and kidney-related bone and stone disorders. The total accuracy rate of GPT-4's response was 74%, higher than GPT-3.5 (P < 0.001) but remained below the passing threshold and average scores of nephrology examinees (77%).

Conclusions

ChatGPT exhibited limitations regarding accuracy and repeatability when addressing nephrology-related questions. Variations in performance were evident across various subfields.