bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Utility of Glimepiride and Metformin Fixed-Dose Combination in Obese/Overweight Patients with Type 2 Diabetes Mellitus in Indian Settings
Authors: Sinha Binayak , Kant Saket , Bandyopadhyay Sabyasachi , Mukherjee Sagarika , Sarkar Dasarathi , Singh Kiran P. , Chaudhury Tirthankar , Kumar Surender , Ahmed Rahimuddin , Abhyankar Mahesh , Prasad Ashish , Talathi Mayuri
Published: August 2023

Background:

In India, glimepiride has become a promising option for add-on therapy with metformin in patients with type-2 diabetes mellitus (T2DM) owing to its efficacy, safety, and cost-effectiveness. This study aimed to analyze the clinical utility of multiple strengths of glimepiride and metformin fixed-dose combination (FDC) in obese/overweight patients with T2DM.

Methods:

This case-based questionnaire survey was conducted between June 2020 and June 2021 and included health-care professionals across India to assess the usage pattern of glimepiride and metformin FDC.

Results:

Overall, data from 1345 patients taking multiple strengths of glimepiride and metformin FDC were analyzed, of which 64.7% were men. A total of 57.6% of patients were overweight, 29.4% were obese Class I, 9.6% were obese Class II, and 3.4% belonged to obese Class III. Sedentary lifestyle (60.3%), smoking (36.7%), and emotional stress (33.3%) were the most common risk factors. Among the available strengths, glimepiride 2 mg and metformin 500/850/1000 mg FDC was most widely used in 50.5% and 47.4% of patients from overweight and obese groups, respectively. A total of 90.3% and 89.1% of patients, respectively, from the overweight and obese groups did not observe weight gain. The majority of the patients from overweight and obese groups observed blood pressure within optimum levels (68.5% and 71.4%, respectively). The mean glycated hemoglobin, fasting plasma glucose, and postprandial plasma glucose levels were significantly reduced with posttreatment of glimepiride and metformin FDC with a mean change of 1.4%, 44.3 mg/dL, and 73.5 mg/dL, respectively (P < 0.01). The physician global evaluation of efficacy (90.3%) and tolerability (91.1%) showed the majority of the patients on a good to excellent scale.

Conclusion:

The real-world evidence in the Indian clinical setting indicates that the glimepiride and metformin FDC was found to be effective in achieving glycemic control and it is observed to be safer in terms of weight gain and hypoglycemia.
Minimizing Hypoglycemia with Insulin Therapy
Authors: Priya Gagan , Grewal Emmy
Published: August 2023

Iatrogenic hypoglycemia is the most feared and common complication of insulin therapy. Hypoglycemia can have serious consequences and can be potentially life-threatening. In addition to the neurological manifestations of severe hypoglycemia, hypoglycemia may be associated with cognitive dysfunction, cardiovascular events, arrhythmias, and increased mortality. Recurrent episodes of hypoglycemia may lead to hypoglycemia unawareness, which increases the risk of severe hypoglycemia. Therefore, prevention of hypoglycemia remains a priority in persons with diabetes on insulin therapy. The “THINK” strategy provides a comprehensive approach for diabetes care providers to minimize the risk of hypoglycemia related to insulin therapy by mitigating factors that increase the risk. This requires setting reasonable glycemic Targets keeping in mind a person's risk of hypoglycemia; choosing the right Tools such as insulin formulation and regimen with lower risk and adequate glucose monitoring; judicious Titration of insulin doses; use of modern Technology such as continuous glucose monitoring, continuous subcutaneous insulin infusion, and sensor augmented pumps in patients at high risk; maintaining Harmony between insulin dose, diet, physical activity, and changes in lifestyle; Individualization of diabetes therapy; ensuring there are No errors in insulin administration; and empowering patients with Knowledge about hypoglycemia. The THINK strategy offers a handy tool for tailoring insulin therapy to minimize hypoglycemia risk.
Emerging Trends in Dermatophytosis among Pediatric Age Group - A View from the South
Authors: Satheesh Durga , Bhat Ramesha M. , Madhumita Monisha , Jayaraman Jyothi
Published: August 2023

Background:

Dermatophytosis is a common dermatological condition in children. Recent trends indicate increasing occurrence of dermatophytic infection in the paediatric age group and with growing anti-fungal resistance; however, more studies describing clinic-epidemiological and mycological pattern in paediatric population are needed.

Aims and Objectives:

The present study was undertaken to assess the clinical pattern and mycological isolates from the lesions of dermatophytosis involving the glabrous skin and to assess the association of fixed dose combinations creams with clinical and mycological pattern of cutaneous dermatophytosis.

Materials and Methods:

Paediatric patients (ages 1 -14) with suspected tinea infections presenting in the Department of Dermatology at a tertiary care medical college hospital in South India for a duration of four months, in 2020, were included in this study. Samples were collected and tested for potassium hydroxide (KOH) positivity. Additionally, the scales were also sent for fungal culture.

Results:

Out of 45 patients, 29 (64.4%) were male and 16 (35.6%) were female. The groin was the most common site affected in 89.65% patients. Around 57% of the study participants (21/45) have used corticosteroid-containing creams. Out of the 45 study participants, KOH mount was positive in 39(86.7%). Fungal Culture revealed Trichophyton mentagrophytes (55.6%) as the most common species isolated.

Conclusion:

Our study illustrates a major epidemiological shift of dermatophytosis causing species from Trichophyton rubrum to Trichophyton mentagrophytes among paediatric patients akin to that observed in adults. It is also observed that there is an increase in an atypical presentation owing to topical steroid use. The present study provides evidence that a high index of suspicion in needed to effectively curb the rising incidence of dermatophytosis in paediatric patients.
The Diagnostic Dilemma of Rothmund-Thomson Syndrome Type II: A Rare Disorder with a Novel Mutation in the RECQL4 Gene in an Indian Boy
Authors: Goyal Manisha , Bharadia Lalit , Gupta Ashok , Kotecha Udhaya H.
Published: August 2023

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder caused by homozygous or compound heterozygous mutations in RECQL4 gene and has characteristic clinical features of poikiloderma, congenital bone defects, gastrointestinal disturbances such as chronic diarrhea and vomiting, and an increased susceptibility to malignancy. A 2½-year-old Indian boy presented with reticulate hyperpigmented erythema with superimposed hypopigmented atrophic macular lesions over the cheeks and diffuse background hyperpigmentation with multiple discrete atrophic hypopigmented macules of variable size over the abdomen and extensor aspects of the forearms. X-rays suggested metaphyseal irregularity around knee joint and radioulnar synostosis. Whole-exome sequencing was suggestive of a de novo novel RECQL4 gene mutation causing RTS Type II. There is an overlapping of clinical features of the group of syndrome associated with skin lesions, skeletal, and gastric manifestations. All these conditions present a challenge to the clinician. Thus, molecular diagnosis is the only way to resolve these phenotypically similar conditions. This report expands the RECQL4 gene pathogenic mutations spectrum.
Gemcitabine Inhibits the Progression of Pancreatic Cancer by Restraining the WTAP/MYC Chain in an m6A-Dependent Manner
Authors: Cao Pei , Zhang Weigang , Qiu Junyi , Tang Zuxiong , Xue Xiaofeng , Feng Tingting
Published: August 2023

Purpose Pancreatic cancer (PC) is a common malignant tumor of the digestive system, and its 5-year survival rate is only 4%. N6-methyladenosine (m6A) RNA methylation is the most common post-transcriptional modification and dynamically regulates cancer development, while its role in PC treatment remains unclear.Materials and Methods We treated PC cells with gemcitabine and quantified the overall m6A level with m6A methylation quantification. Real-time quantitative reverse transcription polymerase chain reaction and Western blot analyses were used to detect expression changes of m6A regulators. We verified the m6A modification on the target genes through m6A-immunoprecipitation (IP), and further in vivo experiments and immunofluorescence (IF) assays were applied to verify regulation of gemcitabine on Wilms’ tumor 1–associated protein (WTAP) and MYC.Results Gemcitabine inhibited the proliferation and migration of PC cells and reduced the overall level of m6A modification. Additionally, the expression of the “writer” WTAP was significantly downregulated after gemcitabine treatment. We knocked down WTAP in cells and found target gene MYC expression was significantly downregulated, m6A-IP also confirmed the m6A modification on MYC. Our experiments showed that m6A-MYC may be recognized by the “reader” IGF2BP1. In vivo experiments revealed gemcitabine inhibited the tumorigenic ability of PC cells. IF analysis also showed that gemcitabine inhibited the expression of WTAP and MYC, which displayed a significant trend of co-expression.Conclusion Our study confirmed that gemcitabine interferes with WTAP protein expression in PC, reduces m6A modification on MYC and RNA stability, thereby inhibiting the downstream pathway of MYC, and inhibits the progression of PC.
Erratum to “The line bundles on moduli stacks of principal bundles on a curve”
Authors: Biswas Indranil , Hoffmann Norbert
Published: August 2023

A missing hypothesis is added to Lemma 2.2.1 in [Doc. Math. 15 (2010), 35–72]. The
rest of the text remains unchanged.
Evaluation of two commercially available rumen buffers derived from calcified seaweed for grazing dairy cows: Pilot trial in commercial farms
Authors: Rivero J.M. , Merino V.M. , Plaza J.E. , Pena J.
Published: August 2023

Calcified seaweed (CS) based products have been proposed as an alternative ruminal pH buffer to sodium bicarbonate. It has been reported that magnesium can aid in ruminal pH control too, especially those natural marine forms. We assessed the rumen buffer capacity and milk production and milk composition of two CS: Acid Buf (AB) compared with M12 (a natural marine magnesium enriched CS) on grazing dairy cows in a replicated Latin Square design involving 2 farms with the dairy herd in good sanitary and health status, 2 supplements and 4 measurements periods of one month each. Holstein Friesian dairy cows fed with a partial mixed ration (PMR) were supplemented for 30-d periods with either AB or M12. Total milk production and milk composition were measured in each farm, and five cows in each herd had rumen boluses for the monitoring of ruminal pH, allowing us to identify and monitor total subacute ruminal acidosis (SARA) events (i.e., = 2 h with pH < 5.8). The average pH during the experimental period was 2% greater (p < 0.05) and the number of SARA events per cow was lower (p = 0.007) for cows supplemented with M12 compared to AB. If only the cows that developed SARA events were considered, M12 showed a trend (p = 0.068) to reduce the number of SARA events and their duration compared to those cows supplemented with AB. Milk production and composition were similar between both rumen buffers at all periods.
KESEGARAN JASMANI SISWA SMAN 1 DANGIA DI MASA PANDEMIK COVID-19
Authors: Abadi Resky Ana , Ika Sartika
Published: August 2023

Physical fitness is the ability of a person to carry out his daily duties easily, without feeling excessively tired, and still having leftover or spare energy to enjoy his spare time and for sudden needs. Good physical fitness can increase body immunity during the Covid-19 pandemic. This study used a qualitative descriptive approach to determine the level of physical fitness of students of SMAN 1 Dangia during the Covid-19 pandemic. The sample in this study was 40 students in  Kolaka Timur Regency using purposive sampling technique. Physical fitness of the students of SMAN 1 Dangia was in the good category as many as 55% or as many as 22 students, the moderate category was 40% or as many as 16 students and 5% were in the poor category.

Abstrak

Kesegaran jasmani adalah kemampuan seseorang untuk menunaikan tugasnya sehari-hari dengan mudah, tanpa merasa lelah yang berlebihan, serta masih mempunyai sisa atau cadangan tenaga untuk menikmati waktu senggangnya dan untuk keperluan-keperluan mendadak. Kesegaran jasmani yang baik dapat meningkatkan imunitas tubuh pada masa pandemik covid-19. Penelitian ini menggunakan pendekatan deskriptif kualitatif untuk mengetahui tingkat kesegaran jasmani siswa SMAN 1 Dangia dimasa pandemik covid-19. Sampel dalam penelitian ini adalah 40 siswa di Kabupaten Kolaka Timur dengan menggunakan teknik purposive sampling. Kesegaran jasmani siswa SMAN 1 Dangia masuk dalam kategori baik sebanyak 55% atau sebanyak 22 siswa, kategori sedang sebesar 40% atau sebanyak 16 siswa dan 5% masuk dalam kategori kurang.

Kata Kunci:  Kesegaran Jasmani, Siswa
TECNOLOGIAS DE APRENDIZAGEM INTEGRADAS
Authors: Gaspar Alexandre Paiva , Caciatori Amneris Ribeiro , Cabral Marcio da Veiga , Ferrari Renata Fermino , Teracin Vera Cristina Souza
Published: August 2023

Este estudo trata dos desafios e impactos oriundos do uso de tecnologias integradas às práticas pedagógicas em sala de aula. Ainda busca destacar os muitos benefícios que as novas tecnologias proporcionam para o processo ensino e aprendizagem, discorrendo pelas dificuldades do docente para se adaptar ao uso desses novos recursos, que reforçam a necessidade da capacitação contínua desse profissional. Sabemos que o professor tem ciência da importância da aplicação das tecnologias como ferramenta de apoio ao ensino em sala de aula, mas, além de saber manusear o recurso ele precisa saber relacionar o conteúdo proposto ao instrumento tecnológico adequado, daí a necessidade de permanente capacitação do professor a fim de desenvolver habilidades necessárias para propor uma aprendizagem que seja significativa e integrada com o uso das tecnologias digitais em sala de aula. Diante desses desafios que permeiam os processos do ensino e aprendizagem com inserção de novas tecnologias, percebe-se que o grande impasse da educação atual é ser capaz de aplicar os recursos tecnológicos integradores disponíveis atualmente alinhando-os as teorias tradicionais da educação para que esses recursos de fato estimulem o conhecimento.
OS ALUNOS DA ESCOLA HOJE
Authors: Ribeiro Claudia , Polizello Ângela  Ap. de A. , Almeida Agnólia Pereira de , Meroto Monique Bolonha das Neves , Santos Silvana Maria Aparecida Viana
Published: August 2023

Resumo: Estamos vivendo em um momento em que a leitura e a informação estão cada vez mais acessíveis e disponíveis devido à democratização proporcionada pela internet e pelas diversas redes sociais. Com um dispositivo nas mãos, podemos facilmente acessar textos, vídeos, podcasts, filmes e documentários sobre uma infinidade de temas, além de nos comunicarmos com pessoas de diferentes lugares. A geração Screenager nasce, cresce e desenvolve sua identidade nesse contexto contemporâneo de informação em massa. No entanto, é contraditório que alunos inseridos na era digital, com acesso fácil à informação, encontrem dificuldades dentro da estrutura escolar e nas atividades propostas lá. Diante dessas questões, o objetivo deste trabalho é compreender as características de personalidade da geração screenager por meio de uma pesquisa bibliográfica, a fim de visualizar os desafios que esses alunos podem enfrentar no ambiente escolar, bem como as dificuldades enfrentadas pelos professores. Foi possível observar que algumas habilidades dos alunos podem dificultar as interações sociais e de aprendizagem dentro da escola, especialmente quando os professores se mantêm inflexíveis aos antigos métodos de ensino. Portanto, é necessário que haja uma maior flexibilidade, principalmente por parte dos docentes, a fim de promover o engajamento dos alunos.
INTEGRAÇÃO DA APRENDIZAGEM COLABORATIVA COM A TAXONOMIA DE BLOOM
Authors: Modesto Valéria Teixeira , Almeida Agnólia Pereira de , Dias Graciele , Andrade Jaqueline Edy de , Pareschi Sheila Costa Silva
Published: August 2023

A educação colaborativa e tecnologia integrada com a taxonomia de Bloom, promove para as equipes e o docente parâmetros assertivos refletidos no trabalho colaborativo dos alunos quando direcionados para uma Aprendizagem Baseada em Projetos (ABP). O objetivo deste trabalho é estimular o uso de ferramentas digitais colaborativas e propor soluções inovadoras a um desafio para a realização de projetos, respeitando o trabalho em equipe considerando os objetivos em comum dos envolvidos. A aprendizagem colaborativa e tecnologia torna o processo de produção dinâmico e contribui para o alcance dos objetivos esperados, além de, fornecer dados para lista de critérios de avaliação. A implementação de tecnologias digitais numa prática colaborativa em projetos, permite ao docente e discentes refletirem se os critérios do aprendizado foram alcançados e em que nível se encontram conforme o grau de aprendizado e objetivos a serem alcançados do nível mais simples aos mais complexos. A metodologia utilizada foi revisão bibliográfica realizada a partir do referencial teórico abordado na disciplina Educação Colaborativa e Tecnologia e de autores sobre taxonomia de Bloom, escolhidos de acordo com as discussões e assuntos requeridos para a construção do conhecimento. Conclui-se que este trabalho exibe assuntos importantes sobre aprendizagem colaborativa e tecnologia aplicadas em projetos.
Molecular Modeling
Authors: Bharat Kumar S. Ankalagi  , Nagaraj Gangadhar Hanshul  , Ramprasad H.  , Sudeep Shetty  , Tejaswi M.N.  , Dr. Sindhu Sree M.  , Dr. Pavithra G  , Dr. T.C.Manjunath
Published: August 2023

In this paper, the modelling of molecule is presented. Chemistry, as the central science, utilizes models in virtually every aspect of the discipline. Integral to the progress of chemistry has been its ability to draw from physics, mathematics, statistics, and computer science to develop new sub disciplines, such as computational chemistry. As computing hardware has become faster and more accessible, so to have techniques to perform modelling and simulations of molecular systems. Software systems today assist researchers in the study of molecular systems and provide mechanisms for deriving a rigorous and consistent explanation for the chemical or biological behaviour observed or help the researcher to develop a model for predictions. Molecular modelling is a field that encompasses a wide range of theoretical and computational methods used to represent the structure and behavior of molecules, ions, and particles. These models can be classified based on their length and time scales, ranging from electronic-level models to continuous-level models. One of the main applications of molecular modelling is in drug discovery, where it can be used to predict the activity and behavior of molecules in the body, aiding in the design of new drugs. Additionally, molecular modelling plays a crucial role in materials science, where it can be used to design new materials with specific properties, such as strength, flexibility, and conductivity. With advances in computing hardware and software, molecular modelling has become an increasingly powerful tool in the fields of chemistry, physics, biology, and materials science, allowing researchers to gain a deeper understanding of the behavior of molecules and particles at the molecular level. The work done & presented in this paper is the result of the mini-project work that has been done by the first sem engineering students of the college and as such there is little novelty in it and the references are being taken from various sources from the internet, the paper is being written by the students to test their writing skills in the starting of their engineering career and also to test the presentation skills during their mini-project presentation. The work done & presented in this paper is the report of the assignment / alternate assessment tool as a part and parcel of the academic assignment of the first year subject on nanotechnology & IoT.
Active Power Factor Correction
Authors: Dr.S.N.Dhurvey  , Sagar Sakhare  , Shubham Wase  , Nikhil Manawar
Published: August 2023

Lower in Power Factor of electrical equipment's will draws high current from supply power. The effect of this is affected by impedance of electrical equipment. Power factor correction of boost converter is done by using predictive control strategy. In this project predictive control algorithm is presented based on this algorithm all of the duty cycles required to achieve unity power factor in one half line period are calculated in advance by proportional Integral (PI) controller, the simulation results show that the proposed predictive strategy for PFC achieves near unity power factor. The power factor and input current distortion are analyzed using with control and without control techniques. Simulation results are shows that the power factor is higher than 0.99, and current total harmonics distortion (THD) is smaller than 20% under full load condition. In this project is how impedance of electrical equipment affects the power factor of electrical loads, and then distributed power as the whole. This project is important to verify the right action to increase low power factor effectively for electrical energy efficiency concern.
Da'wah of Betawi Scholars in the Development of Islamic Society in the 19th-21st Century
Authors: Anim Sarbini
Published: August 2023

Ulama Betawi in the 19th to 21st centuries played an important role in the development of the Muslim community in Jakarta. They helped spread Islam through education and preaching, as well as playing an active role in the formation of religious organizations. In addition, they also played a role in the economic development of the Muslim community through entrepreneurship and economic empowerment. The contribution of the Ulama Betawi was an important factor in the development of the Muslim community in Jakarta during that period. The Ulama Betawi also played a role in maintaining the unity of the Muslim community in Jakarta. They often served as guides in solving social problems that occurred among Muslim communities, such as family, economic, and other social issues. They also played a role in preserving the traditions and culture of Betawi that developed among the Muslim community in Jakarta. The Ulama Betawi realized that Betawi traditions and culture were an integral part of the identity of the Muslim community in Jakarta and as one of the cultural treasures that needed to be preserved. This research uses a qualitative method with a historical approach to understand the concept of dakwah and the role of the Ulama Betawi in the development of the Muslim community in Jakarta in the 19th to 21st centuries. Data was obtained from various sources such as literature, archives, historical documents, and interviews with Ulama Betawi figures. A historical approach was used to describe the development of dakwah and the development of the Muslim community in the past. The results showed that the Ulama Betawi played an important role in the development of the Muslim community in Jakarta through dakwah and socio-economic development strategies. This method provides a holistic perspective and can provide inspiration for the development of dakwah and the Muslim community in the future. The contribution of the Ulama Betawi in the development of the Muslim community in Jakarta in the 19th to 21st centuries was significant. They played an important role in spreading Islam, maintaining the unity of the community, and preserving the culture and traditions of Betawi that developed among the Muslim community.
Kualitas Pelayanan Publik dalam Penerbitan Persetujuan Bangunan Gedung di Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu
Authors: Heryanto Yanto , Sutarjo Moh. , Ramadhani Resa
Published: August 2023

This research title is “Public Service Quality in Issuing Building Approval at the Office of Investment and One Stop Integrated Services, Cirebon Regency. So far, the public’s mind that PBG services seem complicated and convoluted, old services and less than optimal. Therefore, the formulation of the problem in this study is how the quality of PBG publishing services, what factors contribute to PBG issuance and what effort need to made to optimize PBG publishing services at DPMPSTP Cirebon Regency. This research uses qualitative research with a descriptive approach. Data collection techniques used interview, observation and documentation techniques used interview, observation and documentation techniques in the form documents and archives related to the quality of PBG services at DPMPTSP Cirebon Regency. The conclusion of the study is that PBG services at DPMPTSP Cirebon Regency have been going well although there are still some things that are not optimal and need to be improved. Researchers suggest that the services provided by DPMPTSP Cirebon Regency must be more professional, effective, efficient and the existing deficiencied need to be improved so that optimal.
Falsafah Tallu Lolona dan Perspektif Teologi Penciptaan Norman Wirzba sebagai Landasan Ekoteologi Kontekstual
Authors: Pakpahan Binsar Jonathan , Masseleng Hiskianta Septian
Published: August 2023

This article builds a contextual eco-theology based on the Toraja’s local wisdom of tallu lolona and Norman Wirzba's eco-theology to respond to the environmental crisis, especially in Toraja. Tallu lolona is the philosophy of the Toraja people which shows the relationship between humans, animals, and plants as fellow creatures. The relations between creations should form a harmony because no creature should be dominant than others. Meanwhile, Norman Wirzba emphasized that God is the creator and humans should not dominate other creations; they are responsible for protecting and caring for them. Through descriptive methods with the theology of creation, the research shows that the philosophy of tallu lolona combined with the emphasis on God is the creator and humans are only part of creation, strengthen the contextual eco-theology especially for the Toraja people. Humans must no longer abuse other creation purposes for their interests but must respect and care for them. Artikel ini membangun ekoteologi kontekstual berdasarkan falsafah Tallu Lolona dan ekoteologi Norman Wirzba untuk menjawab krisis lingkungan hidup khususnya di Toraja. Tallu Lolona merupakan falsafah masyarakat Toraja yang memperlihatkan hubungan manusia, binatang dan tumbuhan sebagai sesama ciptaan. Relasi antar ciptaan membentuk kerukunan dan harmoni karena tidak ada yang lebih dominan. Sementara Norman Wirzba memberi penekanan bahwa Tuhan adalah pencipta dan manusia tidak boleh mendominasi ciptaan lain, bahkan bertanggung jawab untuk menjaga dan merawatnya. Melalui metode deskriptif dan pendekatan teologi penciptaan, penelitian menunjukkan bahwa falsafah Tallu Lolona yang dikombinasikan dengan penekanan bahwa Tuhan adalah pencipta dan manusia hanya bagian dari ciptaan, membuat bangunan ekoteologi kontekstual khususnya bagi masyarakat Toraja menjadi kuat. Manusia tidak boleh lagi menyalahgunakan tujuan ciptaan lainnya untuk kepentingan dirinya, namun harus menghargai bahkan merawatnya.
Multidisciplinary Approach and Therapeutic Advances in the Management of Meningioma: A Comprehensive Review
Authors:   Hospital de Especialidades Dr. Bernardo Sepulveda Gutiérrez. Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI.Hospital de Especialidades Dr. Bernardo Sepulveda Gutiérrez. Instituto Mexicano del Seguro Social. Centro Médico Nacional Siglo XXI., Mendoza Alejandro Arias , Muñoz Avendaño Ana Laura Esmeralda ,   Hospital General de Zona 6 Tepeji Del Río – Instituto Mexicano del Seguro Social, México., Blancas Luis Daniel Mendoza ,   Facultad de Medicina, Universidad Nacional Autónoma de México. México, Hernández Torres Lisset Guadalupe ,   Hospital general de zona 2. Instituto Mexicano del Seguro Social. Aguascalientes, Aguascalientes, México., Velasco Mónica Maya ,   Escuela Superior de Medicina, Instituto Politécnico Nacional. México., Altamirano Alexis Genaro Ortíz ,   Escuela Superior de Medicina, Instituto Politécnico Nacional. México.
Published: August 2023

Meningioma, a predominantly benign intracranial neoplasm originating in the meninges, has been the subject of extensive study in the medical community due to its prevalence, clinical diversity, and associated therapeutic challenges. This article aims to provide a comprehensive review of current advances in the understanding, diagnosis and treatment of meningiomas, focusing on the application of multidisciplinary approaches and innovative therapies. Through a detailed exploration of the molecular pathogenesis, updated histopathologic classifications, and varied clinical presentations of meningiomas, an in-depth understanding of the inherent heterogeneity of these neoplasms is sought. The importance of advanced neuroimaging, including diffusion-weighted MRI and positron emission tomography, in the accurate assessment of tumor extent and precise surgical planning will be highlighted. In the therapeutic arena, conventional options, such as surgery and radiation therapy, will be examined in detail and the challenges and limitations associated with these modalities will be discussed. In addition, emerging pharmacologic therapies, such as angiogenesis inhibitors and therapies specifically targeting genetic mutations frequently found in meningiomas, will be reviewed, highlighting their potential to modify the clinical course of the disease. The multidisciplinary approach, involving close collaboration between neurosurgeons, neuroradiologists, pathologists and oncologists, will be explored in detail, highlighting its crucial role in informed clinical decision making and optimizing patient outcomes. Finally, future prospects and areas of ongoing research, such as immunotherapy and gene therapy, which promise to further revolutionize the therapeutic paradigm for meningiomas, will be outlined. This article will provide a comprehensive overview of meningiomas, from their molecular basis to state-of-the-art treatment strategies, with the purpose of enriching medical knowledge and fostering a holistic approach in the care of patients affected by this complex pathological entity.
Philosophical Analysis of Teachers’ Perceptions on Instructional Media for Students’ Academic Performance in Civics in Morogoro, Tanzania
Authors:   St. Augustine University of Tanzania, Department of Philosophy and Ethics P.O. Box, 307, Mwanza-Tanzania., Muhamba Denis , Kisandu Francis ,   St. Augustine University of Tanzania, Department of Philosophy and Ethics P.O. Box, 307, Mwanza-Tanzania., Komu Seraphine ,   St. Augustine University of Tanzania, Department of Philosophy and Ethics P.O. Box, 307, Mwanza-Tanzania., Kemikimba Catherine F. ,   St. Augustine University of Tanzania, Department of Journalism and Mass Communication P.O. Box, 307,Mwanza-Tanzania, Manyama Tabu A. ,   St. Augustine University of Tanzania, Department of Journalism and Mass Communication P.O. Box, 307,Mwanza-Tanzania
Published: August 2023

The use of instructional media, a combination of text, graphics, audio, and animations, has been shown to positively impact students’ learning and retention of memory. This study aimed to explore teachers' perceptions of using instructional media to enhance the academic performance of secondary school students in Civics in Morogoro Municipality, Tanzania. Using a survey research design of twenty respondents using questionnaires and eight structured interviews with heads of schools, data were analysed thematically for qualitative data and descriptive statistics was used for quantitative data. The findings revealed that teachers perceived instructional media as essential tools that deepened students' understanding of content, improved recall, motivated students, provoked curiosity, reduced truancy, and increased creativity and innovation. The study concluded that instructional media are essential for students' academic performance, and recommended the establishment of a conducive environment for schools to use instructional media in the teaching and learning process. Philosophically, this study underscores the importance of incorporating different learning modalities to facilitate students' learning and the need for educators to be aware of the benefits and limitations of various instructional tools to maximize students' academic potential.
Forgetfulness of Being as the Biggest Threat to Humanity
Authors:   P.o. Box 1878 Morogoro, Tanzania Assistant Lecturer in Philosophy at Jordan University College in Morogoro, Nari Mr. Thomas Joseph ,   affiliated with Urbaniana University of Rome, Italy.
Published: August 2023

This paper attempts to describe the major issue confronting humanity. I contend that the greatest threat to mankind is human forgetting of being, or rather the perception one has of what constitutes being. The way one interprets being influences one’s orientation and attitudes towards that being. As a result, it is critical to have a clear conception of being, one that does not compromise the uniqueness of each creature. As a result, throughout our conversation, we will look at the meaning of being, different ways of being, and the interdependence of being. The paper also investigates what is meant by amnesia of being and what causes forgetfulness. It went on to say that human arrogance, fueled by some antagonistic worldviews, is the main issue undermining other people’s individuality. The study proposed various viable counter-threat approaches as a remedy to the problem. As a result, unless such orientations and attitudes are clearly addressed and understood, humanity will undoubtedly continue to face the repercussions of being forgetful.
AUTENTIKASI ISRĀILIYYĀT DALAM TAFSIR AL-QUR’AN
Authors: Rohmah Khoirida , Mildasari Dina Aulia
Published: August 2023

Latar belakang pada penelitian ini ialah untuk menanggapi Isrāiliyyāt sebagai salah satu instrumen dalam penafsiran Al-Qur’an. Artikel ini berfokus pada apa dan bagaimana Isrāiliyyāt masuk dalam penafsiran al-Qur’an beserta tokoh-tokohnya, berbagai perspektif terkait Isrāiliyyāt serta autentikasi Isrāiliyyāt dalam tafsir al-Qur’an. Adapun tujuan penelitian Ini adalah untuk mengetahui keautentikan kisah-kisah Isrāiliyyāt dalam penafsiran al-Qur’an. Metodologi yang digunakan dalam penelitian ini adalah studi kepustakaan (library research), data-data yang telah dikumpulkan dari beberapa sumber, diseleksi lalu dirangkai ke dalam hubungan-hubungan sehingga menjadi suatu bentuk penulisan deskriptif. Teori yang digunakan dalam artikel ini adalah naqd al-matan dan naqd sannad yaitu meninjau riwayat dari segi internal maupun eksternal dengan memperhitungkan terhindarnya matan dari illat, syadz  dan  mempertimbangkan kesahihan sanad.  Hasil dari penelitian ini adalah terdapat tiga pandangan terkait autentikasi Isrāiliyyāt dan penggunaanya dalam penafsiran, yaitu: 1) receptionist, 2) rejectionist, 3) sintesa kreatif.  Penelitian ini menjadi penting dibahas, karena tanpa disadari kehadiran Isrāiliyyāt dapat menimbulkan bahaya yang bisa merusak akidah, sehingga isu terkait Isrāiliyyāt ini perlu dikaji dengan benar agar tidak menimbulkan salah persepsi dalam memahami Al-Qur’an mengingat al-Quran adalah kitab sekaligus pedoman hidup manusia, manuskrip yang terjaga dari pemalsuan serta keautentikannya dijamin Allah SWT. Eksistensi Al-Qur’an tidak sekedar dibaca kemudian dihafal, namun dipelajari dan dikaji dari berbagai disiplin ilmu pengetahuan oleh manusia sepanjang zaman, sehingga jika dalam penafsiran terdapat kekeliruan maka fatal akibatnya.
KONSEP UMMAH WĀHIDAH DALAM AL-QUR’AN DAN RELEVANSINYA DENGAN KONTEKS KEKINIAN
Authors: Nurmansyah Ihsan , Oktaviana Sherli Kurnia , Annisa Nur
Published: August 2023

Pada dasarnya umat Islam di seluruh dunia adalah ummah wahidah. Namun kenyataannya, sebagian umat Islam malah saling konflik dan berpecah belah disebabkan perbedaan pendapat, pandangan, dengan saling menyalahkan dan mengkafirkan. Oleh karena itu, bagaimana konsep dari kedua tafsir yang ditulis oleh Hamka dan Kementerian Agama RI dalam merespon problem tersebut yang mana corak kedua tafsirnya membicarakan tentang masyarakat. Metode yang digunakan adalah metode komparatif. Hasil penelitian ini adalah 1) Hamka dan Kementerian Agama RI sependapat mengartikan ummah wahidah adalah satu akidah tauhid dan satu suka berbuat baik. Keduanya, sama-sama memberikan cara untuk mewujudkan ummah wahidah dengan kembali kepada kitab yang mengandung kebenaran dan menyebutkan faktor yang menjadi kendala terwujudnya ummah wahidah, yakni sifat dengki. Perbedaannya, dalam menguraikan makna, kendala dan cara mewujudkan ummah wahidah, Hamka lebih rinci, sedangkan Kemeterian Agama RI lebih sederhana; 2) Konsep ummah wahidah yang ditawarkan Hamka dan Kementerian Agama RI masih sangat relevan dengan konteks kekinian. Dari kedua kitab tafsirnya memberikan solusi agar umat Islam berpegang kepada Kitab al-Quran dan as-Sunnah. Sementara itu, Hamka secara spesifik memberikan cara agar manusia kembali kepada kesatuannya dengan mencari titik temu yang mengacu kepada nilai-nilai kebaikan, bahkan sebagai sarana untuk berlomba-lomba dalam kebaikan; 3) Implikasinya umat Islam harus merubah mindset dan bersikap dewasa untuk menerima perbedaan yang ada.
Manajemen Anestesi pada Pasien Obstetri dengan Kelainan Jantung Kongenital dan Risiko Hipertensi Pulmonal
Authors: Hartono Pinter , Rahardjo Sri
Published: August 2023

Jumlah ibu hamil dengan penyakit jantung saat ini meningkat tajam dikarenakan perbaikan daya tahan anak- anak yang lahir dengan masalah penyakit jantung kongenital. Hal ini dapat meningkatkan frekuensi faktor risiko kardiovaskular pada wanita usia subur dan penyakit kardiovaskular merupakan penyebab tersering kematian maternal di negara berkembang. Perubahan kardiovaskular selama kehamilan menambah beban dari penyakit pada ibu hamil dengan penyakit jantung dan dapat meningkatkan kejadian morbiditas dan mortalitas peripartum. Kehamilan merupakan problematika terkait kardiovaskular pada ibu hamil dengan hipertensi pulmonal. Perubahan anatomis dan fisiologis kardiovaskular selama kehamilan serta kelainan patologis jantung yang dimiliki harus menjadi pertimbangan dalam memilih mode persalinan dan pembiusan. Fase kritis terjadi pada saat persalinan dan pascapersalinan. Kondisi yang harus diperhatikan adalah menghindari peningkatan tahanan vaskular pulmonal, penurunan systemic vascular resistance (SVR), kelebihan cairan, nyeri, dan mencegah terjadinya sindrom Eisenmenger serta gagal jantung kanan.
Peleas de perros y razas potencialmente peligrosas en la legislación mexicana
Authors: Torres Alfaro Dinorah del Carmen
Published: August 2023

El estudio de los daños y delitos ambientales ha figurado en los últimos años en las investigaciones criminológicas contemporáneas. Sin embargo, a pesar de ello, el maltrato animal sigue siendo un tópico poco explorado al no considerársele relevante en comparación con el estudio de otras conductas antisociales. La presente investigación revisa la legislación estatal y federal en lo que respecta a las peleas de perros, así como la regulación y/o prohibición de ciertas razas al considerárseles potencialmente peligrosas. Se encontró que los marcos legales tienen una visión antropocentrista al centrarse en sancionar la actividad sin velar por el bienestar animal. Si bien la legislación en materia animal ha tenido grandes avances en sancionar la crueldad hacia estos, el Estado es laxo en las sanciones penales y administrativas, así como no existen medidas, además de las legales, que disuadan la comisión de la crueldad contra los animales y contribuyan a la eliminar la estigmatización de ciertas razas caninas al considerárseles peligrosas.
On Roger Penrose's Even-Handed Marriage of General Relativity and Quantum Mechanics
Authors: Bollinger Terry
Published: August 2023

The simplest, most self-consistent path to unifying general relativity and quantum mechanics is rein-terpreting classical mechanics' single-frame xyzt operators as emergent behaviors that lose resolution at the lower end, giving quantum mechanics, and transition smoothly into curved space at the high end.
Advancements in Smart Thermostat Technology for Enhanced HVAC Energy Management
Authors: Ireneo C. Plando, Jr.
Published: August 2023

This study examines the transformative potential of smart thermostat technology in revolutionizing Heating, Ventilation, and Air Conditioning (HVAC) energy management. Through a combination of literature review and empirical analysis, the research explores the significance of energy-efficient HVAC systems in reducing carbon footprint and energy costs. Traditional thermostat limitations, including inflexible scheduling and lack of user engagement, underscore the need for innovative solutions. The evolution of smart thermostat technology is traced from basic programmable thermostats to advanced systems integrated with learning algorithms, occupancy sensing, and the Internet of Things (IoT). Empirical data from surveys, case studies, and energy consumption analysis showcase the tangible impact of smart thermostat adoption. Energy savings of up to 30% in commercial settings and 25% in residential contexts underscore the technology's potential for efficiency. User satisfaction surveys reveal improved comfort levels and satisfaction with remote control capabilities. Challenges such as installation complexities and data security concerns highlight areas for improvement. Data analytics and machine learning emerge as pivotal in enhancing smart thermostat efficiency, contributing to additional energy savings. Comparisons between smart thermostat models underscore the importance of occupancy sensing and remote control features in optimizing energy efficiency and user satisfaction. The study's findings suggest a promising avenue for transforming HVAC energy management towards a more sustainable and user-centric approach
A Study on the Effects of Business Performance of Core Competency and Obstacles in Small Manufacturers
Authors:   The Korean Career·Entrepreneurship & Business Association, Kim Daegu , Ha Kyusoo
Published: August 2023

This study analyzes the effect of core competency and obstacles of small manufacturer, Also, it analyzes how much more positive impact could be made by competitive advantage by the mediated effect. For this study, data was collected from 293 CEO by using questionnaires. The statistics analysis SPSS 24.0 and Process macro was used, it is a factor analysis, reliability test and multiple regression analysis, Process macro for hypothesis verification. The result of the study is the following. First, as a result of examining the effect of the core competency on the business performance, it was found that among the core competency factors, marketing competency and technology competency had a significantly positive effect on the business performance. Second, as a result of examining the effect of obstacles factor on the business performance, financing had a negative effect on the business performance. Thirdly, in the relationship between core competency, obstacles factor and business performance, the mediating effect of competitive advantage was significant marketing competency→competitive advantage→business performance, technology competency→competitive advantagey→business performance, financing→competitive advantagey→business performance. Thus, the results of the present study provide the following managerial implications. First, government should provide support to enhance marketing competence and technical competence for sustained competitive advantage and better performance in small manufacturers. Second, marketing competency and technology competency may be a good strategic orientation for sustained competitive advantage and better performance.
A Study on the Support Plan for Small Business Labor Education and Consulting policies through Needs analysis
Authors:   The Korean Career·Entrepreneurship & Business Association, Kim Sunghwan , Kim Minchang
Published: August 2023

This study attempted to analyze needs for labor education and consulting support based on 166 survey responses collected by conducting a survey of small business owners who are direct consumers of policies, and it is meaningful in that it derived Needs and priorities for each labor management items. For each of the 10 labor management items analyzed by the study, it was confirmed that there is a significant gap between the importance perceived by small business owners and the achievement they are actually acquiring. In addition, according to the results fo deriving the priorities of education and consulting needs using Borich needs assessment and the locus for focus model, it was confirmed that education and consulting support for 'employment contract' and 'wage and severance pay' items were the most urgent. The policy implications of this study are as follows. First, labor education and consulting support for small business owners in the future should be implemented with the priority of ‘employment contract’ and “wage and severance pay” items, which are high need and have a large difference between importance and current achievement level. Second, education and consulting should focus on detailed and specific cases. In addition, it is necessary to consider using various types of online and mobile channels such as YouTube and SNS. The analysis results and implications of this study can be used as useful basic data for preparing successful labor education and consulting support plans for small business.
Task-Oriented Training With Cognitive Strategies for Adults With Stroke to Improve ADL and/or Functional Mobility Performance (2012–2019)
Authors: Geller Daniel , Goldberg Carly , Winterbottom Lauren , Nilsen Dawn M. , Mahoney Danielle , Gillen Glen
Published: August 2023

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. This Systematic Review Brief presents findings from the systematic review on interventions to improve activities of daily living and functional mobility performance for people with stroke. This theme reports on task-oriented training with cognitive strategies.