bluuebunny/crossref_metadata_2025 huggingface dataset:
Von Vulkan zu Vulkan – Inselhopping auf den Liparischen Inseln
Authors: Steinecke Hilke , Schubert Peter
Published: December 2020

Die Liparischen Inseln sind der Nordküste Siziliens vorgelagert und vulkanischen Ursprungs. Die bekannteste Insel ist Stromboli mit gleichnamigem Vulkan, der permanent aktiv ist. Alle sieben Inseln haben ihr eigenes Gesicht. Die einzelnen Inseln werden hinsichtlich ihrer Pflanzenwelt und Geologie vorgestellt. Sie wurden im Jahr 2000 in die Liste der UNESCO-Weltkulturerbe aufgenommen und sind bisher glücklicherweise von Negativeigenschaften eines Massentourismus verschont geblieben.
Historische Darstellungen blühender Agaven
Authors: Maué Hermann , Steinecke Hilke
Published: December 2020

Die Amerikanische Agave (Agave americana) war in vorlinnéscher Zeit unter dem Namen Aloe americana bekannt. Wenn Agaven in herrschaftlichen Gärten zur Blüte kamen, war das eine große Attraktion. Blühende Exemplare der sog. Aloe americana wurden auf Gemälden, Kupferstichen und Medaillen abgebildet. Einige Beispiele hierfür werden vorgestellt.
Kohlröschen – mehr als nur Nigritella nigra
Authors: Baumann Kurt
Published: December 2020

Das Kohlröschen (Nigritella) ist eine in den Alpen weit verbreitete Orchideen-Gattung. Lange unterschied man nur zwischen dem Roten und dem Schwarzen Kohlröschen (Nigritella rubra und N. nigra). Heute unterscheidet man 18 Arten, Unterarten und Varietäten. Gymnadenia ist eine mit Nigritella eng verwandte Gattung, weshalb Kohlröschen von manchen Botanikern auch als Gymnadenia bezeichnet werden. Äußeres Erscheinungsbild, Biologie und Verbreitung von Kohlröschen werden vorgestellt.
Jan de Koning, Gerda van Uffelen, Alicja Zemanek & Bogdan Zemanek: Drawn after Nature. The complete botanical watercolours of the 16th-century Libri Picturati
Authors: Steinecke Hilke
Published: December 2020

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Schuljahr im Palmengarten Helmholtzschüler entdecken die Faszination der Pflanzenwelt
Authors: Hummel Annette
Published: December 2020

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Lotosblumen (Nelumbo Adans.) im heimischen Gartenteich?
Authors: Schubert Peter , Lorenz Jutta , Ullrich Dirk
Published: December 2020

Der indische (Nelumbo nucifera) und der amerikanische Lotos (Nelumbo lutea) sind außerordentlich attraktive Wasserpflanzen. Nelumbo nucifera hat hohen Symbolwert in den südostasiatischen Kulturen, wird in Asien aber auch als Nahrungspflanze sehr geschätzt. Die Oberfläche der Blätter hat wichtige Hinweise zur Entwicklung selbstreinigender Oberflächen von Kunststoffen und Lacken geliefert. Weil für die Blütenentwicklung Sommertemperaturen über 20 °C notwendig sind, ist Lotos im Freiland mitteleuropäischer Gärten kaum zu finden. Wenn man jedoch bestimmte Kulturmaßnahmen beachtet, ist seine Freilandkultur in sommerwarmen Gebieten Deutschlands durchaus zu empfehlen. Davon konnte man sich in den letzten Jahren im Botanischen Garten in Mainz und im Palmengarten in Frankfurt überzeugen.
Alma de l'Aigle: Ein Garten
Authors: Wittstock Karin
Published: December 2020

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Berkheya – bew(a)ehrte Blütenwunder
Authors: Nürnberger Sven
Published: December 2020

Südafrika ist das Hauptverbreitungsgebiet der Gattung Berkheya. Berkheya purpurea und B. multijuga dringen bis in die kühlen Gebirgsregionen der Drakensberge vor und verfügen daher über eine entsprechende Kälte- und Frosttoleranz. Ihre auffallend gefärbten Korbblüten von beachtlicher Größe machen sie für den Staudengarten interessant.
Frank Erdnüss: Blütenpracht am Lago Maggiore
Authors: Steinecke Hilke
Published: December 2020

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Acer pentaphyllum – eine Rarität unter den Ahornen
Authors: Dörken Veit Martin
Published: December 2020

Acer pentaphyllum ist ein kleiner, laubabwerfender Baum aus der westchinesischen Provinz Sichuan. Am Naturstandort ist dieser Ahorn mit weniger als 200 Individuen als extrem stark gefährdet einzustufen. Innerhalb der Ahorne hat diese Art eine einzigartige, charakteristische Blattform. Die Blätter sind handförmig gefiedert und haben 5 bis 7 Fiederblättchen.
Vielfalt der Eichen im Palmengarten
Authors: Kamm Katharina
Published: December 2020

Eichen wachsen weltweit in den unterschiedlichsten Lebensräumen. Weltweit gibt es über 500 Eichenarten. Auch im Palmengarten werden etwa 30 Arten kultiviert. Ihre Vielgestaltigkeit soll an interessanten Exemplaren kurz vorgestellt werden.
subalpine Gebirgsflora in Teneriffas Nationalpark Teide
Authors: Goetz Rolf
Published: December 2020

Der Teide-Nationalpark befindet sich im Zentrum der Kanareninsel Teneriffa. Mit jährlich bis zu 4 Millionen Besuchern ist er die am meisten besuchte Touristenattraktion der Kanarischen Inseln. 2007 wurde die Region von der UNESCO zum Weltnaturerbe erklärt. Neben einer spektakulären Vulkanlandschaft zeichnet sich das Schutzgebiet durch die außergewöhnliche Bergflora mit zahlreichen Endemiten aus. Die wichtigsten Arten werden kurz vorgestellt.
Jahr 2017 im Palmengarten
Authors: Steinecke Hilke , Wessel Manfred , Bayer Clemens
Published: December 2020

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Schönheit und Vielfalt der Palmen im Detail
Authors: N N
Published: December 2020

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Alcantarea imperialis – eine Riesenbromelie im Tropicarium
Authors: Schulmeyer Karl-Heinz
Published: December 2020

Alcantarea imperialis gehört zu den größten Bromelien. Sie blüht regelmäßig im Tropicarium des Palmengartens. Die Art wurde durch den berühmten Landschaftsarchitekten Burle Marx in Brasilien als Zierpflanze populär.
Norbert Griebl: Die Kosmos Alpenflora. Alle Arten der alpinen und subalpinen Stufe.
Authors: Steinecke Hilke
Published: December 2020

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Dictamnus albus (Diptam), eine äußerst attraktive Staude in der Steppenwiese des Palmengartens
Authors: Steinecke Hilke
Published: December 2020

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Herbstliche Farbenpracht des Amberbaums (Liquidambar styraciflua)
Authors: Steinecke Hilke
Published: December 2020

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Paul Smith (Editor): The book of seeds. A lifesize guide to six hundred species from around the world.
Authors: Steinecke Hilke
Published: December 2020

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Flatter-Ulme (Ulmus laevis), Baum des Jahres 2019
Authors: Dörken Veit Martin , Jagel Armin
Published: December 2020

Die Flatter-Ulme (Ulmus laevis) ist Baum des Jahres 2019. Von den beiden anderen heimischen Ulmen-Arten unterscheidet sie sich deutlich durch ihre Brettwurzeln. Durch Flussbegradigungen und Trockenlegungen von Auengebieten sind ihre Bestände zurückgegangen. Die Flatter-Ulme ist seltener vom Ulmensterben betroffen als die Berg- und Feld-Ulme. Das Ulmensterben beruht auf einer Infektion durch Schlauchpilze der Gattung Ophiostoma. Die Pilze können in die Ulmen eindringen, wenn diese vorher vom Ulmensplintkäfer (Gattung Scolytus) befallen worden sind.
großen wissenschaftlichen Leistungen von Stefan Vogel (1925–2015) Teil 5c. Öl statt Nektar– die Ölblumen (monokotyle Vertreter und abschließende Bemerkungen)
Authors: Weber Anton , Gerlach Günter , Schäfer Hanno
Published: December 2020

Bei den Monokotyledonen haben sich Ölblumen in zwei Familien entwickelt: Iridaceen und Orchideen. Bei ersteren (mit Trichom-Elaiophoren) zweimal, bei letzteren mindestens 10 mal voneinander unabhängig (sowohl Trichom- als auch Epithel-Elaiophoren). Wichtige Vertreter aus beiden Familien, die bereits von Stefan Vogel entdeckt wurden, werden näher dargestellt und illustriert. Abschließend werden folgende Aspekte der Ölblumen angesprochen: Pflanzengeographie, Evolution und sekundärer Verlust der floralen Ölproduktion, Mimikry und Voraussage in der Wissenschaft.
Henning Haeupler: Vom Äquator zu den Polarkreisen. Vegetationsbilder der Erde
Authors: Steinecke Hilke
Published: December 2020

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Sven Nürnberger, Hilke Steinecke, Theodor C. H. Cole: Palmengarten Frankfurt am Main. Gartenreisen.
Authors: N N
Published: December 2020

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Makrofotografie mit der Stacking-Technik am Beispiel von Nadelgehölz-Zapfen
Authors: König Peter , Luhn Michael
Published: December 2020

Herkömmlichen Makroaufnahmen mangelt es häufig an Tiefenschärfe. Ein neuartiges digitales Verfahren („Stacking“) nimmt Objekte abschnittsweise auf und fügt die scharfen Anteile der Bilder rechentechnisch zusammen, so dass die Motive von vorn bis hinten scharf wiedergegeben werden. Die fotografisch erzielbaren Resultate dieser Technik werden am Beispiel von Nadel- gehölzblüten vorgestellt.
Farbklecks in der Nebelwüste
Authors: Wehlmann Christian
Published: December 2020

Sisyndite spartea ist ein wärmeliebender Strauch. Er kommt von Südafrika bis Namibia vor. Sisyndite spartea wurde 2015 im Palmengarten ausgesät und wächst nun im Nebelwüstenhaus des Tropicariums. Durch den heißen und sonnigen Sommer 2019 wurde die Entwicklung zahlreicher gelber Blüten gefördert. Sisyndite spartea gedeiht sehr gut und ist zudem sehr pflegeleicht.
Winterschutz für empfindliche Gewächse im Winter 2019/2020
Authors: N N
Published: December 2020

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Tiere und Pilze in Frankfurts Botanischen Gärten – ein Bürgerwissenschaftsprojekt
Authors: Steinecke Hilke
Published: December 2020

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Frühling 2006 in Bangalore
Authors: Schauer Roland
Published: December 2020

Die Gebäude des Indian Institute of Science im südindischen Bangalore sind in einem großen Park verstreut, der eine Vielzahl von tropischen Pflanzen beherbergt. Der waldähnliche Park wird auch von zahlreichen Tieren, insbesondere Vögeln, belebt. Ende Februar 2006 zeigte sich das Gelände trotz großer Trockenheit in schönem Frühlingsflor, wobei vor allem Tabebuia-, Jacaranda- und Cassia-Bäume ein eindrucksvoll buntes Bild lieferten.
Naturnahe Wälder im Rhein-Main-Gebiet
Authors: Offer Christian
Published: December 2020

Im Rhein-Main-Gebiet gibt es noch Reste naturnaher Waldvegetation. Ihre große ökologische Bedeutung wird erläutert, einige ihrer charakteristischen Baum-Arten werden vorgestellt.
Poor Knights Lily – eine seltene Schönheit vom anderen Ende der Welt
Authors: Dressler Stefan
Published: December 2020

Eine eigentümliche monokotyle Pflanze mit leuchtend roten, flaschenbürstenförmigen Blütenständen und schwertlilienartiger Belaubung wird vorgestellt: die Poor Knights Lily (Xeronema callistemon). Diese Art hat ein sehr kleines Verbreitungsgebiet: Sie ist endemisch auf zwei der neuseeländischen Nordinsel vorgelagerten Inselgruppen. Sie wächst an offenen Felsstandorten und wird teilweise von Meerwasser übersprüht. Einige Kulturhinweise werden gegeben.
Weihnachtskaktus (Schlumbergera) – beliebte Zimmerpflanze zur Winterszeit
Authors: Kasielke Till
Published: December 2020

Weihnachtskakteen (Schlumbergera spp.) stammen aus dem atlantischen Regenwald Brasiliens. Aufgrund ihrer Blütezeit im Winter sind sie beliebte Weihnachtspflanzen. Sie werden in vielen Kulturvarietäten angeboten. Biologie, Ökologie und Kulturbedingungen werden vorgestellt.
Anzucht von Farnen aus Sporen
Authors: Schwerdtfeger Michael
Published: December 2020

Im Alten Botanischen Garten Göttingen wurden in den letzten Jahren zahlreiche Farne erfolgreich durch Aussaat von Sporen vermehrt. Im Beitrag werden praktische Tipps zur Vermehrung von Farnen gegeben.
Effect of the 7E Instructional Strategy on the Overall Attitude of Students in Biology in Public Secondary Schools in Adamawa State, Nigeria
Authors: Shuaibu Abdullahi , Ishak Nor Asniza
Published: December 2020

The effect of attitude as a psychological construct that impacts students achievement in secondary schools have been widely reported, and the need to address that non-cognitive trait, so as to improve students’ achievement have been stressed. Negative attitude of students have adversely affected educational outcomes and the need to improve this trait in students is the aim of this study. The study investigated the effect of the 7E instructional strategy on the overall attitude of students of the 11th grade, in Biology, in public secondary schools in Adamawa State, Nigeria. Four attitude constructs, namely; attitude towards Biology as a subject; attitude towards the Biology teacher; perception of importance of Biology and perception of difficulty of Biology; were used in the study. Two randomly selected schools were denoted as experimental and control groups and were taught using the 7E instructional strategy and the teacher-centered methods, respectively. A 38-item Likert-based questionnaire was used to collect data before and after intervention was given. The research question was answered by the means and standard deviations, while the hypothesis was analysed using the Analysis of Covariance (ANCOVA) statistics. The descriptive statistics results showed that the experimental group had higher mean scores in three out of the four attitude variables, while no significant difference was recorded on one variable. The overall attitude of students taught by the 7E instructional strategy and when taught by traditional teacher-centered method, showed that students’ attitude is positively affected, by the 7E instructional strategy. Therefore, 7E instructional strategy significantly improved students’ attitude towards Biology.
Scaling Gifted Children’s Dominant Characteristics Using Pair-Wise Comparison Method
Authors: BÜYÜKKIDIK Serap , ŞİMŞEK Ayşe
Published: December 2020

Introduction: In this study, it is aimed to conduct a scaling study to determine the dominant characteristics of gifted children who attend Science and Art Centers (SAC). In this scaling study, the opinions of the parents of the children identified with gifted/talented were taken. Method: The dominant characteristics of gifted children were collected under eight statements by the researchers. Data were collected from 204 parents who voluntarily participated in the descriptive research. Results: At the end of the scaling process with the Case V and Case III Full Data Matrix, it was seen that the parents ranked the dominant characteristics in gifted children as strong curiosity, keen powers of observation ability, vivid imagination, high degree of creativity, rapid learning ability, good problem solving / reasoning ability, extensive vocabulary, and perfectionism, respectively. Conclusion and Discussion: At the end of the research, it has been determined that the stimulus sequences obtained by the Case V and Case III equations are completely consistent with each other. When the scale values are examined, it is seen that the intervals of the scale values obtained from the Case III equation are wider than the Case V equation. The scale values obtained from the Case III equation are higher than the scale values obtained from the Case V equation.
APLICAÇÃO DE FERRAMENTAS LEAN EM UMA INDÚSTRIA DE TRANSFORMAÇÃO DE PLÁSTICOS
Authors: Santos Bruno Sousa , Souza Santos Pedro Vieira
Published: December 2020

A indústria de plásticos cresce com a globalização, trazendo novas perspectivas produtivas, e o aumento do consumo e da concorrência exige das empresas uma melhor utilização dos seus recursos. Este artigo teve como objetivo apresentar um estudo de caso de como uma organização pode desenvolver uma formulação objetiva e prática para eliminar desperdícios  em uma indústria de plásticos. Tal formulação baseia-se em utilizar ferramentas do Lean Manufacturing. Através da análise e solução de problemas verificou-se a possibilidade de implementar a gestão visual e a padronização das tarefas. Após tais modificações, observou-se inicialmente um ganho substancial em comparação com configuração anterior. Após implantação das melhorias foi alcançado à redução significativa dos desperdícios no processo. Através da análise dos dados dos resultados obtidos, verificou-se uma resposta positiva à proposta inicial. Podemos concluir que com a adoção das novas configurações foram obtidos ganhos de produtividade, redução de tempo de produção e aumento de eficiência do processo.
Acid Ceramidase, a Double-edged Sword in Cancer Aggression: A Minireview
Authors: Vethakanraj Helen Shiphrah , Chandrasekaran Niveditha , Sekar Ashok Kumar
Published: December 2020

Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway, hydrolyzes
pro-apoptotic ceramide to sphingosine, which is metabolized to mitogenic sphingosine-1-phosphate
by the action of sphingosine-1-kinase. The intracellular level of AC determines ceramide/
sphingosine-1-phosphate rheostat, which in turn decides the cell fate. The upregulated AC
expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic
ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is
decreased, and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether
aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited
increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous
strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological
inhibition of AC sensitized the resistant cells to chemo/radiotherapy, thereby promoting
cell death. The core objective of this review is to explore AC mediated tumour progression and the
potential role of AC inhibitors in various cancer cell lines/models.
Importance of BODIPY-based Chemosensors for Cations and Anions in Bio-imaging Applications
Authors: Kursunlu Ahmed Nuri , Bastug Elif , Guler Ersin
Published: December 2020

Background:

Chemosensor compounds are useful for sensitive selective detection of cations and anions with fluorophore groups in an attempt to develop the effective selectivity of the sensors. Although familiar fluorescent sensors utilizing inter-molecular interactions with the cations and anions, an extraordinary endeavor was executed the preparation of fluorescent-based sensor compounds. 4,4-difluoro-4- bora-3a,4a-diaza-s-indacene (Bodipy) and its derivatives were firstly used as an agent in the imaging of biomolecules due to their interesting structures, complexation, and fluorogenic properties. Among the fluorescent chemosensors used for cations and anions, Bodipy-based probes stand out owing to the excellent properties such as sharp emission profile, high stability, etc. In this review, we emphasize the Bodipy-based chemosensor compounds, which have been used to image cations and anions in living cells, because of as well as the biocompatibility and spectroscopic properties.

Methods:

Research and online content related to chemosensor online activity is reviewed. The advances, sensing mechanisms and design strategies of the fluorophore exploiting selective detection of some cation and anions with Bodipy-based chemosensors are explained. It could be claimed that the using of Bodipy-based chemosensors is very important for cations and anions in bio-imaging applications.

Results:

Molecular sensors or chemosensors are molecules that show a change can be detected when affected by the analyte. They are capable of producing a measurable signal when they are selective for a particular molecule. Molecular and ion recognition that it is important in biological systems such as enzymes, genes, environment, and chemical fields. Due to the toxic properties of many heavy metal ions, it is of great importance to identify these metals due to their harmful effects on living metabolism and the pollution they create in the environment. This process can be performed with analytical methods based on atomic absorption and emission. The fluorescence methods among chemosensor systems have many advantages such as sensitivity, selectivity, low price, simplicity of using the instrument and direct determination in solutions. The fluorescence studies can be applied at nanomolar concentrations.

Conclusion:

During a few decades, a lot of Bodipy-based chemosensors for the detection of cations & anions have been investigated in bio-imaging applications. For the Bodipy-based fluorescent chemosensors, the Bodipy derivatives were prepared by different ligand groups for the illumination of the photophysical and photochemical properties. The synthesized Bodipy-based chemosensors have remarkable photophysical properties, such as a high quantum yield, strong molar absorption coefficient etc. Moreover, these chemosensors were successfully implemented on living organisms for the detection of analytes.
Challenges to Antiretroviral Therapy Adherence and Coping Strategies to Overcome Them: Qualitative Investigations of Adolescents Living with HIV, their Caregivers, and Clinicians in Vietnam
Authors: Sabin Lora L. , Nguyen Vu Cong , Harvey Kelsee , Bonawitz Rachael , Hai Le Thanh , Van Lam Nguyen , Yen Le Thi , Gifford Allen L. , Haberer Jessica E. , Linh Dang Thuy , DeSilva Mary Bachman
Published: December 2020

Background:

Adolescents living with HIV (ALHIV) in Vietnam are known to struggle with adherence to Antiretroviral Therapy (ART).

Objective:

To examine treatment challenges and facilitators experienced by ALHIV from the perspective of adolescents, their caregivers, and providers, and to inform an adherence intervention.

Methods:

In-depth Interviews (IDIs) of adolescent/caregiver dyads and Focus Group Discussions (FGDs) with adolescents, caregivers, and clinicians were conducted in Hanoi, Vietnam. We used semi-structured guides to encourage open-ended responses. We queried the challenges adolescents experience taking ART medications and being adherent, their awareness of disease status, and facilitators to support high adherence. Audio-recorded IDIs were translated into English, and coded and analyzed in NVivo using a thematic approach.

Results:

A total of 78 individuals participated in the study. Forty individuals participated in IDIs (20 adolescents and 20 caregivers). All adolescents had acquired HIV perinatally. We conducted six FGDs: four with adolescents, and one each with caregivers and clinicians. We identified major themes regarding awareness of HIV status (most caregivers reported they had disclosed to their child, while few adolescents revealed the knowledge of their status); perceived barriers to adherence (medication-related challenges, stigma, school-associated issues, financial obstacles, system challenges, awareness of HIV status); and adherence facilitators (development of dose-taking habits, reminder systems, social support). Differences between adolescents and caregivers related to key issues were evident.

Conclusion:

Further research is needed to elucidate discrepancies in adolescent-caregiver viewpoints and develop interventions tailored to both ALHIV and their caregivers.
COVID-19 Pandemic: Physical Activity as Prevention Mean
Authors: Hammami Nadhir , Jdidi Hela , Frih Bechir
Published: December 2020

Background:

The consequences of the new pandemic caused by the Coronavirus Disease 2019 (COVID-19) have ruined the whole world. To date, more than 180 countries have been affected with more than 13 million people afflicted of all categories (young people, the elderly, athletes, and children) and more than 500,000 deaths around the globe. Moderate-intensity physical activity should be recommended as a non-pharmacological, low-cost, and feasible mean to cope with the COVID-19 virus

Objective:

The first objective is to provide an overview of the COVID-19 pandemic along with the evolution of this disease, the modes of inter-persons transmission, and the symptoms. The second objective is to suggest means of prevention for people, including the practice of regular physical activity.

Conclusion:

No drugs or treatments exist until today. The solution remains confinement in order to minimize contact between people (social distancing) and the strengthening of the immune system through a healthy lifestyle (healthy food and regular physical and sports practice) in addition to the recommended preventive measures.
Gene Expression of GSK3 in Type II Diabetics Compared to Non-Diabetics (ex vivo)
Authors: Khorami Somayeh A.H. , Mutalib Mohd S. Abd , Shiraz Mohammad F. , Abdullah Joseph A. , Rejali Zulida , Ali Razana M. , Khaza’ai Huzwah
Published: December 2020

Background:

GSK3 is a serine/threonine kinase that is involved in the storage of glucose into glycogen through the negative regulation of glycogen synthase. Defects in GSK3 and glycogen synthase function are early stages of the development of insulin resistance, which may cause impaired glycogen synthesis in Type II diabetes.

Methods:

In this cross-sectional study, the gene expression level of GSK3 from Type II diabetic and non-diabetic participants was compared via real-time RT-PCR. To investigate the relationships between GSK3 expression and indicators of insulin resistance, Pearson's correlation analysis was performed. To compare the differences between GSK3 expression levels based on BMI categories, one-way ANOVA was used.

Results:

Gene expression of GSK3 was slightly higher in diabetic participants compared to non-diabetics, but it was statistically insignificant. Also, no significant difference was found based on BMI categories in the two groups. No significant association between GSK3 expression and indicators of insulin resistance was observed in non-diabetic participants. There was only a positive significant correlation between GSK3 expression and FBS in diabetic participants.

Conclusion:

These results indicate that the regulation of GSK3 may occur at the translation level, as gene expression level was unaltered between diabetic and non-diabetic participants. Also, since circulating levels of both glucose and insulin regulate GSK3 activity, tissue specificity for the expression and post-translation regulations of GSK3 may exist, which cause hyperactivation or overexpression in some target tissues in diabetes. Furthermore, it is probable that glycogen synthase activity is also regulated by non-insulin mediated mechanisms like exercise or allosteric changes, independent of GSK3 expression.
Lantana undulata Schrank – A New Source of Biological Potential in the
Verbenaceae Family
Authors: Ascendino D.M.S , T.L Barreto , C.E.D Igídio , J.O Castro , J.S.P Sousa , G.M Henriques , M.S Melo , L.D Silva , R.A Oliveira , F.F Oliveira , S.C.O Melo , E.L.A Malpezzi-Marinho , A.O Conceição
Published: December 2020

Background :

The presence of condensed tannins, flavonones, flavonols, flavones, xantones,
catechins and alkaloids in the ethanolic extract of Lantana undulata leaves has been associated
with cytotoxicity and virucidal effect on suid herpesvirus.

Objective:

To evaluate cellular toxicity, antimicrobial and antioxidant activities, and anti-phlogistic
property of the ethanolic extract leaves of Lantana undulata, a plant from the Verbenaceae family.

Method:

Cytotoxicity was evaluated on Madin Darby bovine kidney (MDBK) cells and erythrocytes
and through leukocyte DNA damage. Antibacterial and antifungal activities were performed
using the agar diffusion technique and broth microdilution. The inhibition percentage and viral inhibition
index were established against bovine herpesvirus. The antioxidant effect (EC50) was determined
by the DPPH technique and the mouse ear edema model was used to determine the anti-phlogistic
activity.

Results:

The maximum nontoxic concentration for MDBK cells was 650 μg/ml. The ethanolic extract
of L. undulata was considered non-hemolytic from 2 to 16 μg/ml and not genotoxic at the concentration
tested (<8 μg/ml). High concentrations (3500 μg/ml) were needed to inhibit bacteria and
yeasts, and the action of the extract was bacteriostatic or fungistatic. The IIV was of 0.37 and the
IP was of 57.34% against bovine herpesvirus. The antioxidant EC50 was 540.87 μg/ml and the reduction
of oedema occurred at 10, 30 and 100 mg/kg in the mouse model used.

Conclusion:

Although the ethanolic extract of L. undulataleaves showed to be potentially toxic
and to have a reduced spectrum of action on microorganisms, the outstanding antiphlogistic action
puts the therapeutic potential of this plant into perspective.
Is There A Role of Glycated Hemoglobin for Predicting Major Ad- verse Cardiac Event in ST-Elevation Myocardial Infarction?
Authors: Abusari Muhammad , Tri Tjahjono Cholid , Hendrawan Dadang , Waranugraha Yoga , Asri Devi Adityawati Ayu , Pancasari Ratna
Published: December 2020

Background : Coronary Artery Disease (CAD) especially ST-Elevation Myocardial Infarction (STEMI) is the leading cause of mortality worldwide. Hyperglycemia and diabetes mellitus are both prevalent among patients with STEMI admitted to the hospital. Glycated hemoglobin (HbA1c) is a marker of glucose control. Objectives : We aimed to investigate the role of HbA1c as the predictor of major adverse cardiovascular events in STEMI patients. Methods : This was a retrospective cohort study. STEMI patients visiting Saiful Anwar General Hospital were registered. Patients were divided into three groups based on the HbA1c level <6.5%; 6.5-8.4% and ≥8.5%; respectively. The primary endpoint was in-hospital Major Adverse Cardiovascular Events (MACE), including cardiac death, recurrent myocardial infarction (MI), recurrent revascularization, acute pulmonary edema, cardiogenic shock, malignant arrhythmia, and stroke. Results: A total of 118 STEMI patients were included in this study, with distribution of 61 patients with HbA1c <6.5%, 25 patients with HbA1c 6.5-8.4%, and 31 patients with HbA1c ≥8.5%; respectively. The HbA1C level was associated with the history of diabetes mellitus (3.2% vs 36% vs 71%; p =0.000) and random blood glucose level at hospital admission (140.71 ± 39.67 mg/dL vs 172.96 ± 53.43 mg/dL vs 366.61 ± 169.67 mg/dL; p = 0.000). The MACE among three groups was not significantly different (17.7% vs 20% vs 35.5%; p=0,149). Conclusion: Our study reveals that the HbA1c level at hospital admission is associated with the history of diabetes mellitus and random blood glucose at hospital admission. However, HbA1c could not predict MACE in STEMI patients
Depression and Cognitive Impairment in Patients on Hemodialysis: A cross-sectional study
Authors: Raduan Nor Jannah Nasution , Salleh Mohd Razali , Ahmad Ghazali , Ismail Zaleha
Published: December 2020

Depression and cognitive impairment are the most common complications of patients on hemodialysis. The objective of this study is to identify contributing factors to depression and cognitive impairment in hemodialysis patients. This is a cross-sectional study involving 110 hemodialysis patients in Hospital Kuala Lumpur. The samples were recruited through universal sampling. Patients were assessed with the Beck Depression Inventory and Montreal Cognitive Assessment. This study found that 18.2% of patients had depression, and 48.2% had cognitive impairment. Factors associated with depression were unmarried status, low education level, and cognitive impairment. Factors associated with cognitive impairment were low education level, depression, and unemployment.
Keywords: hemodialysis, depression, cognitive, ESRD
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2468.
A Survey on the Evidence-Based Practice of Optometrists in Malaysia
Authors: Zainodin Elly Liyana , Jantan Nur Dzakirah
Published: December 2020

Evidence-based practice is useful to help healthcare practitioners, including optometrists, to give the best level of patient care. To date, little is known about the form of evidence used by optometrists in Malaysia in their clinical decision-making. A cross-sectional survey that explores the implementation of evidence-based practice was completed online by 137 registered optometrists. Overall, findings indicate that the respondents did not sufficiently apply evidence-based practice in clinical. Time constraints and restriction in access hinder the respondents from reading journals regularly. The evidence-based practice needs to be formally nurtured in optometry education to bridge the gap between research and clinical.   
Keywords: evidence-based practice; optometry; clinical
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2502.
NİKEL (II) İYONLARININ ATIK ÇAY’A BİYOSORPSİYONU: DENGE, KİNETİK VE TERMODİNAMİK ÇALIŞMALARI
Authors: ÖZTÜRK Mustafa , YILDIZ Sayiter , ASLAN Şükrü
Published: December 2020

Bu çalışmada atık çay (AÇ) kullanılarak Ni(II) iyonunun biyosorpsiyonu araştırılmıştır. Ni(II) giderme veriminin (E) ve biyosorpsiyon kapasitesinin (qe) belirlenebilmesi amacıyla temas süresi, sıcaklık, pH, başlangıç Ni(II) derişimi ve AÇ dozu gibi çeşitli deney koşulları altında kesikli deneyler yapılmıştır. Biyosorpsiyonun ilk dakikalarda çok hızlı gerçekleştiği ve ilk 30 dk.’da dengeye ulaşıldığı tespit edilmiştir. Ayrıca pH’ın yükselmesi ile biyosorpsiyon veriminin arttığı ve pH 5–7 arasında en yüksek değerlerde olduğu ve çözelti sıcaklığının artmasıyla qe’nin de yükseldiği belirlenmiştir. Deneysel veriler kullanılarak hesaplanan R2, qden ve qhes değerlerine göre adsorpsiyon eşitliğin en iyi, Langmuir ve Temkin izoterm modelleri ile tanımlanmaktadır. Deney verileri Ni(II) iyonlarının AÇ’ye biyosorpsiyonunun ekzotermik bir reaksiyon olduğunu göstermektedir. Kinetik modeller kıyaslandığında, biyosorpsiyonun en iyi yalancı II. derece kinetik model tarafından tanımlandığı belirlenmiştir. Termodinamik parametreler adsorpsiyon işleminin AÇ tarafından Ni(II) iyonlarının uzaklaştırılmasında kullanılabileceğini göstermektedir. Ayrıca farklı çözücüler ile yapılan desorpsiyon çalışmasında AÇ’nin sorbent olarak yeniden kullanabilirliği belirlenmiştir.
Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study
Authors: Cerniglia Luca , Cimino Silvia , Marzilli Eleonora , Pascale Esterina , Tambelli Renata
Published: December 2020

Background

International research has emphasized that youths are at higher risk for the onset of internet addiction (IA), but studies investigating biological, psychological, and social factors associated with this condition are limited.

Objective

This study aims to investigate the possible association between IA and genetic polymorphisms in monoamine oxidase A (MAO-A), serotonin-transporter (5-HTTPR), dopamine receptor (DRD4), and dopamine transporter (DAT1) genes by considering the role played by the perception of young adults in their family functioning and their depression, anxiety, and avoidant personality problems.

Methods

In a sample of 104 male and female young adults aged between 19 and 23 years (mean age 21.87, SD 2.29 years) recruited from universities in the central southern part of Italy, we addressed the presence of IA using the Young criteria of the IA test. Moreover, the perception of young adults of their family functioning and their psychopathological symptoms were assessed through the Family Assessment Device (FAD) and the Adult Self-Report, respectively.

Results

We found no significant association between IA and any genetic polymorphisms, neither among males or females. Young adults with IA reported significantly higher scores in the subscale of FAD affective responsiveness (AR; P=.01) and in depressive problems (P=.02), anxiety problems (P=.009), and avoidant personality problems (P=.003) than those in the control group. Results of mediation analyses showed a mediation role played by depressive symptoms (B=0.99; 95% CI 0.22 to 1.97) and avoidant personality problems (B=1.09; 95% CI 0.32 to 2.05) of young adults on the relationship between the FAD, AR, and IA. Finally, this relationship was moderated by the genotype of the 5-HTTLPR (P<.001), DAT1 (P<.001), and MAO-A (P<.001) genes in young adults.

Conclusions

This exploratory study supports the recent evidence on the mutual relationship among biological, individual, and social risk factors associated with IA in young adulthood. Our findings may have important clinical implications for the development of prevention and treatment programs.
Use of a Remote Oncology Pharmacy Service Platform for Patients With Cancer During the COVID-19 Pandemic: Implementation and User Acceptance Evaluation
Authors: Chen Zhuo-Jia , Liang Wei-Ting , Liu Qing , He Rong , Chen Qian-Chao , Li Qiu-Feng , Zhang Yao , Du Xiao-Dong , Pan Ying , Liu Shu , Li Xiao-Yan , Wei Xue , Huang He , Huang Hong-Bing , Liu Tao
Published: December 2020

Background

The COVID-19 outbreak has increased challenges associated with health management, especially cancer management. In an effort to provide continuous pharmaceutical care to cancer patients, Sun Yat-sen University Cancer Center (SYSUCC) implemented a remote pharmacy service platform based on its already existing web-based hospital app known as Cloud SYSUCC.

Objective

The aim of this study was to investigate the characteristics, acceptance, and initial impact of the Cloud SYSUCC app during a COVID-19 outbreak in a tertiary cancer hospital in China.

Methods

The total number of online prescriptions and detailed information on the service were obtained during the first 6 months after the remote service platform was successfully set up. The patients’ gender, age, residence, primary diagnosis, drug classification, weekly number of prescriptions, and prescribed drugs were analyzed. In addition, a follow-up telephonic survey was conducted to evaluate patients’ satisfaction in using the remote prescription service.

Results

A total of 1718 prescriptions, including 2022 drugs for 1212 patients, were delivered to 24 provinces and municipalities directly under the Central Government of China between February 12, 2020, and August 11, 2020. The majority of patients were female (841/1212, 69.39%), and 90.18% (1093/1212) of them were aged 31-70 years old. The top 3 primary diagnoses for which remote medical prescriptions were made included breast cancer (599/1212, 49.42%), liver cancer (249/1212, 20.54%), and thyroid cancer (125/1212, 10.31%). Of the 1718 prescriptions delivered, 1435 (83.5%) were sent to Guangdong Province and 283 (16.5%) were sent to other provinces in China. Of the 2022 drugs delivered, 1012 (50.05%) were hormonal drugs. The general trend in the use of the remote prescription service declined since the 10th week. A follow-up telephonic survey found that 88% (88/100) of the patients were very satisfied, and 12% (12/100) of the patients were somewhat satisfied with the remote pharmacy service platform.

Conclusions

The remote pharmacy platform Cloud SYSUCC is efficient and convenient for providing continuous pharmaceutical care to patients with cancer during the COVID-19 crisis. The widespread use of this platform can help to reduce person-to-person transmission as well as infection risk for these patients. Further efforts are needed to improve the quality and acceptance of the Cloud SYSUCC platform, as well as to regulate and standardize the management of this novel service.
User engagement analysis of visual vs text-based summaries of new medical research in the general medical community (Preprint)
Authors: Wu Constance , Chan Alex K. , Cheung Andrew , Succi Marc D.
Published: December 2020

BACKGROUND

In the digital age of publication and era of social media, there is increased need for precise and concise reporting of medical manuscripts to educate students, physicians, and other health professionals. Both visual abstracts (VAs) and textual reports (TRs) have been utilized online, but there is a paucity of study about whether VAs really boost user engagement through visual representation of key study findings. Furthermore, prior studies have focused on specialty journals content as opposed to the general medical community.

OBJECTIVE

The current study was designed to analyze the effectiveness of standardized VAs across the general medical community.

METHODS

In this prospective case-control study, we used Twitter to publish 18 pairs of VAs and TRs from an open-access, physician-run medical news organization with healthcare professional readership across all medical specialties in order to investigate the effect of VAs on user engagement. Each VA/TR pair, which generally covered new research applicable to the general internist, was published on the same day, covered the same content, and had the same title on Twitter; posts for TRs had a nonspecific control image and link to a text abstract, while VA posts had a partial preview and link to the full VA. The outcomes studied were views, engagement rate, and percent change in engagement rate.

RESULTS

Results showed that while there was no difference in number of views on Twitter (P=.83), VAs had significantly higher engagement rates (P=.002), with an average fold change of 2.75 (95% CI 1.83 to 3.67).

CONCLUSIONS

Our results show that Twitter posts containing previews and links to VAs had more user engagement than posts with no visual content and links to TRs, which suggests that VAs are more effective tools for promoting engagement with medical content.
Мониторинг назначений лекарственных препаратов врачами-стоматологами в течение 2019–2020 годов
Authors: Mazur I.P. , Suprunovych I.M. , Stadnyk M.B.
Published: December 2020

Актуальность. Рациональное использование лекарственных препаратов является актуальной проблемой в мире. Ежегодное пополнение фармацевтического рынка Украины новыми препаратами, обновления медицинской информации по использованию, механизмам действия, побочным реакциям обусловливает необходимость информирования врачей и анализа назначений для лечения стоматологических заболеваний. Цель исследования: провести анализ назначений фармакотерапевтических препаратов и средств по уходу за полостью рта врачами-стоматологами за I полугодие 2020 года. Материалы и методы. В исследование включено 5707 респондентов — врачей-стоматологов из всех областей Украины. Исследование было проведено поэтапно во время научно-практических мероприятий в I полугодии 2020 года. Опросы врачей проводились путем заполнения анкеты-опросника, подготовленной ОО «Ассоциация стоматологов Украины», на бумажных носителях и онлайн по основным назначениям лекарственных препаратов и средств ухода за полостью рта. Данные анкеты были статистически обработаны в программе SPSS (Statistical Package for the Social Sciences). Результаты. Результаты исследования показали, что врачи-стоматологи широко используют фармакотерапевтические препараты в своей ежедневной практике; 89,87 % стоматологов регулярно назначают антибактериальные препараты, а именно пенициллины (39,48 %), фторхинолоны (37,57 %), метронидазол (39,18 %). Для лечения болевого синдрома большая часть стоматологов использует нимесулид (85,98 %). Практически все стоматологи (98,8 %) в своей ежедневной практике применяют средства для местного лечения инфекционно-воспалительных процессов: хлоргексидин (68,62 %), метрогил дента (55,11 %), холисал (29,27 %). Проведен анализ назначений средств ухода за полостью рта — зубных паст, ополаскивателей, зубных щеток. Выводы. Результаты анализа назначений фармакологических препаратов и средств по уходу за полостью рта свидетельствуют об их широком использовании в ежедневной практике врачами-стоматологами. Осведомленность врачей-стоматологов о современных фармакотерапевтических препаратах и средствах ухода за полостью рта, об их показаниях, противопоказаниях и возможных взаимодействиях фармакологических препаратов будет способствовать достижению высокоэффективных и клинически предполагаемых результатов лечения.
Клинические состояния: жжение полости рта. Что может разрушить безупречную работу стоматолога — глоссодиния или непереносимость сплавов и материалов?
Authors: Gasyuk N.V. , Mazur I.P.
Published: December 2020

Целью данной публикации являются анализ и синтез ведущих клинических дифференциально-диагностических критериев при состояниях жжения в полости рта. Результаты. В работе приведено аналитическое обобщение клинических критериев диагностики парестетических состояний слизистой оболочки полости рта, которые дадут возможность своевременной и профессиональной диагностики данных заболеваний в повседневной практической деятельности стоматолога. Первое место при анализе этиологических факторов жжения в полости рта занимают нарушение взаимодействия психологических и нейрофизиологических составляющих и дисбаланс именно вегетативной иннервации слизистой оболочки полости рта. Кроме того, выделяют ряд параметров, которые способствуют развитию данного синдрома и включают в себя как местные провоцирующие факторы (ортопедические конструкции, бруксизм), так и соматические (патология внутренних органов и систем). Выводы. Клинические состояния жжения в полости рта целесообразно рассматривать как мультидисциплинарную проблему, которая требует интеграции врачей различных специальностей. Отсутствие унифицированных подходов к систематике и дефицит знаний о доскональных патофизиологических механизмах особенно остро ставят вопрос о целесообразности разработки алгоритмов ведения таких пациентов в Украине и реализации в ежедневной практике стоматолога.
High-Dimensional Pixel Entanglement: Efficient Generation and Certification
Authors: Herrera Valencia Natalia , Srivastav Vatshal , Pivoluska Matej , Huber Marcus , Friis Nicolai , McCutcheon Will , Malik Mehul
Published: December 2020

Photons offer the potential to carry large amounts of information in their spectral, spatial, and polarisation degrees of freedom. While state-of-the-art classical communication systems routinely aim to maximize this information-carrying capacity via wavelength and spatial-mode division multiplexing, quantum systems based on multi-mode entanglement usually suffer from low state quality, long measurement times, and limited encoding capacity. At the same time, entanglement certification methods often rely on assumptions that compromise security. Here we show the certification of photonic high-dimensional entanglement in the transverse position-momentum degree-of-freedom with a record quality, measurement speed, and entanglement dimensionality, without making any assumptions about the state or channels. Using a tailored macro-pixel basis, precise spatial-mode measurements, and a modified entanglement witness, we demonstrate state fidelities of up to 94.4% in a 19-dimensional state-space, entanglement in up to 55 local dimensions, and an entanglement-of-formation of up to 4 ebits. Furthermore, our measurement times show an improvement of more than two orders of magnitude over previous state-of-the-art demonstrations. Our results pave the way for noise-robust quantum networks that saturate the information-carrying capacity of single photons.