bluuebunny/crossref_metadata_2025 huggingface dataset:
Zwischen Internationalismus und Sachpolitik
Authors: Federer Lucas
Published: April 2022

Der Schweizer Trotzkismus in der Nachkriegszeit bestand aus kleinen, aber beständigen politischen Gruppierungen. Diese schafften es trotz ihrer geringen Größe und entgegen dem antikommunistischen Klima der geistigen Landesverteidigung, für sie zentrale Themen in breiteren gesellschaftlichen Kreisen ins Gespräch zu bringen. So etwa den Widerstand gegen die atomare Bewaffnung der Schweizer Armee, die Solidarität mit der algerischen Bevölkerung während des Algerienkrieges oder Forderungen nach einem allgemeingültigen Mindestlohn. Lucas Federer untersucht das Wirken und die politischen Konzeptionen dieser einzigartigen Strömung der Arbeiter*innenbewegung und fragt nach ihrem Einfluss auf die politischen und gesellschaftlichen Entwicklungen der Schweiz im Kalten Krieg.
Sie wollen uns erzählen: Pop(artist) goes literature
Authors: Jürgensen Christoph
Published: April 2022

Christoph Jürgensen erläutert in seiner Einleitung die Fragestellung des Bandes und stellt kurz den zugrundeliegenden theoretischen Ansatz Pierre Bourdieus vor. Es geht darum, wie sich künstlerische Inszenierungsstrategien in den Feldern Literatur und Popmusik gegenseitig beeinflussen können.
»Ich erzähle dir alles, und alles ist wahr«
Authors: Quicker Pascal
Published: April 2022

Pascal Quicker nimmt in diesem Beitrag Tocotronics Album Die Unendlichkeit (2018) und Dirk von Lowtzows Buch Aus dem Dachsbau (2019) in den Blick, um deren werkpolitische Engführung im Graubereich von Autobiographie und Autofiktion zu evaluieren.
»immer haben Typen wie du, was auf die Fresse verdient«
Authors: Buschbeck Celine , Kuhr Martje
Published: April 2022

Celine Buschbeck und Martje Kuhr situieren in diesem Beitrag Bela B Felsenheimers Debütroman Scharnow (2017) im typologisch vertrackten Zusammenhang von Scherz, Satire, Ironie und tieferer Bedeutung, wobei es ihnen vor allem um die qua satirischer Perspektive artikulierte Gesellschaftskritik geht.
Unschuld in Gefahr - Kinder und Gewalt in Till Lindemanns Lyrik
Authors: Mück Michelle , Raschke Katina
Published: April 2022

Michelle Mück und Katina Raschke nähern sich in diesem Beitrag dem lyrischen Werk von Rammstein-Frontmann Till Lindemann über Inhalt und Form und untersuchen Horror und Schockeffekte der Texte, die von Kindern und Gewalt handeln.
Magical Mystery - Der Mythos Musiktour bei Sven Regener
Authors: Tiemann Christian , Göbel Lennart
Published: April 2022

Christian Tiemann und Lennart Göbel widmen sich in diesem Beitrag dem Phänomen der Musiktournee, die hier am Beispiel von Regeners Roman Magical Mystery (2013) und im Rückgriff auf das Begriffsarsenal von Strukturalismus und Poststrukturalismus (namentlich Barthes, Bachtin und Foucault) erläutert wird.
Matter, Affect, AntiNormativity
Authors: Braunmühl Caroline
Published: April 2022

Dualistic thinking has been questioned by some writers associated with the material, ontological, and affective turns. Yet, these and other writers linked to the ›turns‹ have themselves reproduced dualistic theorizing. Caroline Braunmühl also shows that there are dualistic patterns in significant contributions to queer theory as well as Foucauldian diagnoses of the present. From a perspective sympathetic to the critical efforts made by poststructuralist and related theorists, she analyzes works by Sara Ahmed, Karen Barad, Michael Hardt, Antonio Negri, Michel Foucault, and others. The book suggests specific alternatives to dualistic as well as identitarian ways of framing conceptual pairs such as matter/mind, affect/discourse and negativity/affirmation.
MÉTODO, PSICOLOGIA HISTÓRICO-CULTURAL E ONTOLOGIA DO SER SOCIAL:
Authors: Furtado Vanessa , Maia Pinheiro Paulo Wescley
Published: April 2022

O presente artigo visa discutir a centralidade do método materialista histórico e dialético na Psicologia vygotskiana, trazendo contribuições para a construção de uma Psicologia de base marxista, à luz da Ontologia do Ser Social, a partir do referencial teórico de Lukács. Compreendemos que o diálogo entre Vygotski e Lukács pode aclarar questões na Psicologia Histórico Cultural no que se refere ao método e aos procedimentos metodológicos desenvolvidos por Vygotski. A teoria vygotskiana, sob uma leitura da Ontologia do Ser Social, transcende o campo das aparência, buscando as determinações entre universalidade, particularidade e singularidade, compreendendo o sujeito numa perspectiva de totalidade, indo à essência do que nos faz seres humanas (os), numa leitura onto-histórica da subjetividade.
Training for Industry 4.0: a systematic literature review and directions for future research
Authors: Cazeri Gustavo Tietz , Santa-Eulália Luis Antonio de , Serafim Milena Pavan , Anholon Rosley
Published: April 2022

Goal: This study aims to identify, synthesize and classify the main features explored by current research encompassing training for Industry 4.0 and propose directions for future research.
Design / Methodology / Approach: The methodological procedure was oriented by a systematic literature review (PRISMA) methodology and followed by content analysis. After a review of academic databases, 78 papers dealing with training for Industry 4.0 were included and classified based on topics related to the science of training and Industry 4.0.
Results: Most of the studies in training for Industry 4.0 are oriented to undergraduate and graduate students (in an educational approach) or industrial employees (in an enterprise approach) and, in general, they explore technical, technological, and human oriented subjects. There is a lack concerning studies targeting managers who deal with Industry 4.0 and few studies consider content related to Industry 4.0 impact on business models, sustainability, corporate social responsibility, and other related concepts.
Limitations of the investigation: The main limitation is related to the database selection criteria. Search in non-indexed databases, book chapters, and non-English language are not included in this study.
Practical Implications: The findings presented in this paper are relevant for researchers and academics as they can serve as a guide for future research work. Consultants, professionals, and trainers can enhance their courses by including currently less explored content or target audiences.
Originality/Value: No similar papers were found in scientific databases and this reinforces this manuscript's originality and contribution.
Method for aligning the load graph powerful induction plants
Authors: Bazarov Alexander A. , Danilushkin Alexander I.
Published: April 2022

The paper deals with the issues of load balancing in the shop power supply system containing powerful electrothermal installations. There is a cyclical change in load parameters with significant variations in current and power factor during operating multi-section induction installations of methodical action. The largest deviations of these parameters occur in transient modes at heater start or at changing the billets nomenclature. It is shown that when the load changes in starting modes, an increase in power and a decrease in the power factor can lead to unacceptable current overloads of the power supply. Correction during start-up of section currents and power factor allows us to reduce current fluctuations, to provide a smoother power diagram and eliminate power supply overload. It is possible to implement current and power factor correction using semiconductor frequency converters in each section. This approach prevents decreasing the voltage quality indicators and reduces possible deviations of the billets temperature distribution. The parameters of the heater sections in transient modes are calculated. The ranges of power, voltage, current and frequency variation are determined, corresponding to the capabilities of semiconductor frequency converters used in these installations. The proposed start-up algorithm provides the smallest of all possible power fluctuations.
What’s working in Los Angeles? Two decades of achievement gains
Authors: Fuller Bruce
Published: April 2022

A novel set of civic activists arose in Los Angeles in the 1990s, gaining independence from neoliberal advocates and labor leaders to advance a variety of school reforms over the next  three decades. In turn, student learning climbed steadily during the period. This paper first describes the rise of these “new pluralists” – a diverse coalition of black and Latina leaders, civil rights attorneys, pro-equity nonprofits, and pedagogical reformers – and sketches their efforts to equitably fund central-city schools, improve teacher quality and student engagement, and decriminalize discipline. I then review accumulating evidence on which institutional changes empirically predict gains in pupil outcomes, further informed by qualitative studies. These plural actors, rooted in humanist ideals, challenged the individualistic and competitive values of neoliberals. Carving-out a third civic space, they lifted achievement on average, but have yet to find policy strategies that narrow racial disparities in learning.
Poziom rozwoju regionalnego województwa wielkopolskiego w dobie globalizacji w świetle wybranych wskaźników
Authors: Sala Stanisław
Published: April 2022

Wzrost znaczenia regionów w UE jest impulsem do badania rozwoju regionalnego. W publikacji, koncentrując się na zagadnieniach gospodarczych, przedstawiono zarys analizy poziomu rozwoju regionalnego województwa wielkopolskiego na tle najlepiej rozwiniętych województw w kraju. Wyróżniono trzy grupy czynników, takie jak: produktywność, przedsiębiorczość oraz innowacyjność. Produktywność opisano za pomocą PKB, PKB per capita, wartości dodanej brutto i wartości dodanej brutto per capita, przedsiębiorczość scharakteryzowano za pomocą liczby podmiotów gospodarki narodowej oraz wielkości nakładów inwestycyjnych, natomiast poziom innowacyjności określono na podstawie liczby podmiotów i pracujących w działalności badawczej i rozwojowej oraz wielkości nakładów inwestycyjnych na działalność badawczą i rozwojową. Następnie przy użyciu wskaźnika syntetycznego uszeregowano najlepiej rozwinięte województwa w Polsce, wskazując na różnice między kolejnymi cechami.
Rynek mleka w województwie wielkopolskim w latach 2004–2020
Authors: Wiza Paulina Luiza
Published: April 2022

Celem badań było przedstawienie i ocena rynku mleka w województwie wielkopolskim na tle kraju w latach 2004–2020. W pracy analizie poddano produkcję, pogłowie, skup, ceny oraz konsumpcję mleka w województwie wielkopolskim i Polsce. Analizy rozpatrywano w oparciu o dane Głównego Urzędu Statystycznego oraz Instytutu Ekonomiki Rolnictwa i Gospodarki Żywnościowej – PIB w Warszawie. W artykule wykorzystano analizę opisową wspartą tabelaryczną i graficzną prezentacją danych. W oparciu o przeprowadzone badania wykazano, że po integracji Polski z Unią Europejską produkcja w województwie wielkopolskim wzrosła o 73%, podczas gdy pogłowie zmniejszyło się o 0,61%. Tendencja ta jest adekwatna do sytuacji na krajowym rynku mleka. Zmiany zachodzące na rynku mleka w województwie wielkopolskim oraz w Polsce spowodowane są koncentracją chowu krów mlecznych oraz eliminacją z rynku gospodarstw o małej skali produkcji mleka.
Zmiany kierunków użytkowania gruntów ze szczególnym uwzględnieniem użytków rolnych w miastach powiatu poznańskiego w latach 2010 i 2020
Authors: Bąk Mariusz , Abramowicz Dawid
Published: April 2022

Obserwowana  w  Polsce  presja  inwestycyjna  przyczynia  się  do  zmian w użytkowaniu gruntów w miastach, co przejawia się zwłaszcza ubywaniem gruntów rolnych. W literaturze istnieją przykłady badań prowadzonych w tym zakresie na terenie dużych miast w Polsce, jednak w przypadku mniejszych miast badań brakuje. Ważnym problemem jest rozpoznanie tych zmian w mniejszych miastach. Celem opracowania jest analiza zmian w użytkowaniu gruntów ze szczególnym uwzględnieniem gruntów rolnych w miastach powiatu poznańskiego w latach 2010 i 2020. W tym okresie największe zmiany zaszły w Luboniu, Swarzędzu i Mosinie. Powierzchnia gruntów rolnych w tych miejscowościach zmniejszyła się odpowiednio o 17,5%, 10,0% i 9,5%.
Rola samorządu terytorialnego w kreowaniu produktu lokalnego na przykładzie gminy Trzcianka
Authors: Chudzyńska Izabela
Published: April 2022

W 1989 r. w Polsce rozpoczął się proces zmian ustrojowych, które ukierunkowane były na przejście od państwa totalitarnego do demokratycznego oraz od gospodarki centralnie planowanej do wolnorynkowej. Pierwszym zauważalnym efektem tych zmian było zatowarowanie sklepów produktami spożywczymi z całego świata. W tym czasie konsumenci niechętnie sięgali po produkty pochodzące od lokalnych firm, kojarząc je z żywnością gorszej jakości. Z czasem wzorem innych krajów Unii Europejskiej nastąpiło znużenie tanim produktem spożywczym, powstającym na masową skalę. W efekcie regiony oraz poszczególne miasta rozpoczęły poszukiwania charakterystycznych dla nich potraw/produktów, które mogłyby się stać „jedzeniową marką” danego miejsca.

Celem opracowania jest wskazanie roli samorządu terytorialnego w tworzeniu rozpoznawalnego dla miasta/regionu produktu spożywczego. Jako przykład posłużyła tu wielkopolska gmina Trzcianka. Całość badań terenowych przypadła na 2021 r. Wykonano je metodą sondażu diagnostycznego. W ramach badań zrealizowano wywiady z pracownikami Urzędu Miasta w Trzciance, z właścicielami lokalnych piekarni oraz badania ankietowe z mieszkańcami gminy Trzcianka. Wykazano, że w opinii lokalnych przedsiębiorców wsparcie władz gminy ma bardzo duży wpływ na rozpoznawalność ich produktów. Zdaniem mieszkańców trzcianeckie pieczywo jest chętnie przez nich kupowane, choć nie jest kojarzone jako produkt lokalny. Badania wykazały, że brak akcji promocyjnej ukierunkowanej na wybrany produkt spożywczy sprawia, iż pochodzące z trzcianeckich piekarni pieczywo, licznie nagradzane na krajowych piekarskich konkursach, choć mogłoby być, nie jest „jedzeniową marką” Trzcianki.
Distinct morphologies of arterial waveforms reveal preload‐, contractility‐, and afterload‐deficient hemodynamic instability: An in silico simulation study
Authors: Mulder Marijn P. , Broomé Michael , Donker Dirk W. , Westerhof Berend E.
Published: April 2022

Hemodynamic instability is frequently present in critically ill patients, primarily caused by a decreased preload, contractility, and/or afterload. We hypothesized that peripheral arterial blood pressure waveforms allow to differentiate between these underlying causes. In this in‐silico experimental study, a computational cardiovascular model was used to simulate hemodynamic instability by decreasing blood volume, left ventricular contractility or systemic vascular resistance, and additionally adaptive and compensatory mechanisms. From the arterial pressure waveforms, 45 features describing the morphology were discerned and a sensitivity analysis and principal component analysis were performed, to quantitatively investigate their discriminative power. During hemodynamic instability, the arterial waveform morphology changed distinctively, for example, the slope of the systolic upstroke having a sensitivity of 2.02 for reduced preload, 0.80 for reduced contractility, and −0.02 for reduced afterload. It was possible to differentiate between the three underlying causes based on the derived features, as demonstrated by the first two principal components explaining 99% of the variance in waveforms. The features with a high correlation coefficient (>0.25) to these principal components are describing the systolic up‐ and downstroke, and the anacrotic and dicrotic notches of the waveforms. In this study, characteristic peripheral arterial waveform morphologies were identified that allow differentiation between deficits in preload, contractility, and afterload causing hemodynamic instability. These findings are confined to an in silico simulation and warrant further experimental and clinical research in order to prove clinical usability in daily practice.
Mechanical properties, elastic moduli, transmission factors, and gamma-ray-shielding performances of Bi2O3–P2O5–B2O3–V2O5 quaternary glass system
Authors: Tekin Huseyin Ozan , ALMisned Ghada , Rammah Yasser Saad , Susoy Gulfem , Ali Fatema T. , Sen Baykal Duygu , Zakaly Hesham M. H. , Issa Shams A. M. , Ene Antoaneta
Published: April 2022

Mechanical properties, elastic moduli, transmission factors (TFs), and gamma-ray shielding performance of quaternary glass systems with chemical composition (0.25−x)Bi2O3–xB2O3−0.75(50%P2O5−50%V2O5), where x = 0.05 (S1), 0.10 (S2), 0.15 (S3), and 0.20 (S4) mol%, were comprehensively studied. The MCNPX code, Phy-X/PSD software, and the Makishima–Mackenzie model were utilized to achieve the mentioned purposes. The values of the packing density (V
t) decreased from 0.634432 to 0.600611, while those of the dissociation energy (G
t) increased from 51.6125 kJ/cm3 for the S1 glass sample (with Bi2O3 = 5 mol%) to 56.7525 kJ/cm3 for the S4 glass sample (with Bi2O3 = 20 mol%). This means that the mechanical properties were enhanced by increasing the Bi2O3 content in glasses. Linear (µ) and mass attenuation (µ
m) coefficients for the S4 glass sample were the greatest compared to those for glass materials investigated, i.e., (µ, µ
m)S1 < (µ, µ
m)S2 < (µ, µ
m)S3 < (µ, µ
m)S4. Half- and tenth-value layers (HVL and TVL, respectively) follow the trend: (HVL, TVL)S1 > (HVL, TVL)S2 > (HVL, TVL)S3 > (HVL, TVL)S4. The effective atomic number (Z
eff) of investigated glasses has the same trend as of linear and mass attenuation coefficients. Our findings indicate that increasing the amount of Bi2O3 reinforcement decreased the exposure buildup factor and energy absorption buildup factor values for all mean free path values (0.5–40 mfp). All glasses recorded the minimum TF values at a thickness of 3 cm. The findings would benefit the scientific community in determining the most appropriate additive bismuth(iii) oxide/diboron trioxide type and related glass composition to provide the shielding properties previously mentioned in terms of needs and utilization requirements, as well as the most suitable glass composition.
Coefficient of thermal expansion and mechanical properties of modified fiber-reinforced boron phenolic composites
Authors: Zhao Chenglong , Qin Yan , Wang Xiaotian , Xiao Han
Published: April 2022

Boron phenolic resin is widely used in the aerospace field because of its excellent thermal properties. In this article, nitrile rubber powder was added to phenolic resin to modify fiber-reinforced phenolic resin composites. The results showed that the tensile strength continued to decrease; the elongation ratio increased from 20.01% to 32.04%; and flexural strength and flexural modulus reached the highest values of 188 and 9,401 MPa, respectively. Thermal analysis showed that rubber had little effect on the heat resistance at low temperatures, especially below 350°C. Furthermore, the coefficient of thermal expansion of the composites increased from 8.9 × 10−6 to 1.5 × 10−5 K−1, increasing by nearly 70%. The electron microscopy images showed a tortuous fracture path in modified composites, which indicated that rubber powder–modified phenolic composites had a ductile fracture.
Experimental determination of isothermal sections of the Hf–Nb–Ni system at 950 and 1100°C
Authors: Wei Dawei , Zhao Jianyu , Guo Cuiping , Li Changrong , Du Zhenmin
Published: April 2022

The complete isothermal sections of the Hf–Nb–Ni system at 950 and 1100 °C were constructed, in which the phase constituents and compositions of alloy samples were determined by scanning electron microscopy with energy dispersive X-ray spectroscopy, and X-ray diffraction. Nine three-phase regions at 950 °C and nine three-phase regions at 1100 °C were confirmed. Four three-phase regions at 950 °C and five three-phase regions at 1100 °C were proposed. The solid solubilities of third components in the binary compounds were determined. A new ternary compound τ with Hf2Rh structure was found.
Investigation of interdiffusion behavior in the Ti–Zr–Cu ternary system
Authors: Xue Junpeng , Li Hongxiao , Liu Boshu , Ren Yuping , Jiang Min , Qin Gaowu
Published: April 2022

The interdiffusion behavior of diffusion couples Ti-25Zr/Cu, Ti-50Zr/Cu and Ti-75Zr/Cu (at.%) at 973–1073 K was investigated by using electron probe microanalysis. The results show that the diffusion paths in all diffusion couples deviate away from the faster-diffusing Cu–Ti side. The diffusion paths pass the tie-line, across or parallel to, corresponding to the different diffusion layer structures and phase morphologies. The average effective interdiffusion coefficients and activation energies of Cu in both solid solutions and intermetallic compounds were determined. The diffusion coefficients of Cu in β(Ti, Zr) solid solution increase slightly and then decrease with the increase in Zr content, while the diffusion coefficients of Cu in Cu(Ti,Zr)2 intermetallic compound decrease with the increase in Zr content. The diffusion coefficients of Cu in Cu51Zr14 are the largest among all the intermetallic compounds in diffusion couples.
Review of the application of intelligent speech technology in education
Authors: Gao Jianqing , Wan Genshun , Wu Kui , Fu Zhonghua
Published: April 2022

Education is the main application field of intelligent speech technology, including automatic speech recognition and speech assessment. In this paper, we introduce some popular application cases of intelligent speech technology in education, such as intelligent micro-lessons, online distance learning and spoken English learning and testing. With the help of intelligent speech technology, people can acquire knowledge faster, learn languages more efficiently, and even communicate by using different languages. Moreover, we propose three kinds of challenging problems in the application of intelligent speech technology, including the recognition of domain-related terms, the recognition of code-switching and the fine-grained mispronunciation diagnosis. Viable state-of-art solutions to these problems are also discussed in detail. Meanwhile, we also discuss what language teachers and researchers can do in solving the above technical problems.
Overcoming reward deficiency syndrome by the induction of “dopamine homeostasis” instead of opioids for addiction: illusion or reality?
Authors: Blum Kenneth , Soni Diwanshu , Badgaiyan Rajendra D. , Baron David
Published: April 2022

Many individuals in the United States are plagued by addiction, and the rate at which it is affecting people in the United States only seems to be increasing. Research shows that addiction is a preventable disorder rather than a flaw in one’s moral fiber. It is driven by the imbalance of dopamine and the brain’s reward system. Although medication-assisted treatment (MAT), the most common treatment for addiction, are effective in reducing harm, they provide minimal aid in addressing the root cause of this preventable disorder. The authors aim to convey that the proper treatment should help restore dopamine balance so the quality of life can be improved in the recovering community. Osteopathic principles emphasize the importance of homeostasis and allostasis in allowing the body to heal itself. Viewing reward deficiency syndrome (RDS) through this osteopathic lens can bring about treatments that aim to restore the dopamine homeostasis. The article discusses various potential therapeutic modalities that can provide dopamine homeostasis via activation of dopaminergic pathways.
Addressing disparities in medicine through medical curriculum change: a student perspective
Authors: Kureshi Amina , Landman Scott , Ahmed Meher , Savinova Olga V. , Becker Diane
Published: April 2022

Cultural competency training has been a focus of medical schools for some time. An essential step in developing culturally competent physicians, effective cultural competency training has previously been researched at medical schools. Before forming a diversity task force to head cultural competency training, one medical school utilized medical student volunteers to review current teaching material and provide suggestions to increase cultural competency training. A study group consisting of three faculty members and 29 medical students was formed on a voluntary basis during the summer of 2020. Based on medical student opinion and reviewed teaching materials, learning tools were created to guide medical curricular updates. This experience resulted in the formation of four teaching tools: a didactic lecture checklist to include more diverse patient populations; case-based learning objectives that focus on social determinants of health; a facilitator question script to encourage group discussion and student feedback on the given clinical cases; and a student reflection form on the effects of race, gender, and socioeconomic status on patients and medical professionals in the clinical setting. Updating the medical school curriculum is a constant and ongoing process. Forming a diversity task force to guide these changes and regularly review medical teaching materials will help train physicians ready to care for a diverse patient population. In addition, the use of the suggested teaching tools may help guide the review process for such committees at other medical schools.
Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus
Authors: Kurban Sevil , Selver Eklioglu Beray , Selver Muhammed Burak
Published: April 2022

Objectives

Diabetes mellitus (DM) is widely known to have a detrimental effect on bone health and is associated with increased fracture risk. Recently, the Wnt/beta-catenin signaling pathway and its inhibitors sclerostin and dickkopf-1 (Dkk-1) were found to be involved in the control of bone mass. The present study aimed to measure serum sclerostin and Dkk-1 protein levels in children and adolescents with type-1 DM and compare with other bone turnover markers and bone mineral density (BMD).

Methods

This study was performed on 40 children and adolescents with type-I DM and 40 healthy children and adolescents. Anthropometric measurements and pubertal examination were done. In addition to laboratory analysis, dickkopf-1, sclerostin, cross-linked N-telopeptides of type I collagen (NTx), bone alkaline phosphatase (bALP), and osteocalcin levels were studied. BMD of the participants was measured by calcaneus ultrasonography.

Results

Dickkopf-1 levels of the children and adolescents with type-1 DM were significantly higher, vitamin D, NTx, osteocalcin, and phosphorus levels were significantly lower than those of the controls (p<0.001). Fasting blood glucose, HbA1c, and insulin were significantly higher in the type 1 DM group (p<0.01).

Conclusions

Both bone remodeling and its compensatory mechanism bone loss are lower in children and adolescents with type-1 DM than in the controls. Also, higher levels of Dkk-1 play a role in decreased bone turnover in these patients. Since Dkk-1 and sclerostin seem to take a role in treating metabolic bone diseases in the future, we believe that our findings are significant in this respective.
Sensorlose Positionsmessung in elektrischen Antrieben mittels Fluss-Bypass-Verfahren
Authors: Schleicher André , Werner Ralf
Published: April 2022

Sensorlose Messverfahren ermöglichen eine platzsparende und gegen Umgebungseinflüsse unempfindliche Bestimmung der Läuferposition in elektrischen Maschinen. Die konventionellen Verfahren weisen jedoch einen verhältnismäßig hohen Rauschpegel auf und sind empfindlich gegenüber magnetischer Sättigung sowie Veränderungen der elektrischen Betriebsparameter. Beim Fluss-Bypass-Verfahren wird über einen im Stator integrierten Fluss-Bypass die zeitliche Änderung eines Streuflusses im Stator der Maschine gemessen. Die Sättigung des Stators kann damit effektiv kompensiert werden. Die sonst übliche Differenziation des Stroms oder ein aufwändiges Modell zur Ermittlung von Induktivität und Wicklungswiderstand sind nicht erforderlich. Mittels theoretischer und experimenteller Untersuchungen werden der Rauschpegel, die Linearität sowie der Einfluss von Strom, Schaltfrequenz und Tastverhältnis auf das Lagemesssignal untersucht. Das Fluss-Bypass-Verfahren weist eine höhere Linearität, erheblich geringere Rauschpegel sowie eine größere Sättigungstoleranz auf, als eine konventionelle sensorlose Messung mittels Induktivitätsbestimmung. Ein wesentlicher Störeffekt sind Wirbelströme im Material. Bei entsprechender Auslegung des Fluss-Bypasses können innerhalb eines gewissen Messwertbereich parasitäre Efekte verschiedener Art gleichzeitig gemindert werden.
Human APOER2 Isoforms Have Differential Cleavage Events and Synaptic Properties
Authors: Omuro Kerilyn Casey , Gallo Christina M. , Scrandis Lauren , Ho Angela , Beffert Uwe
Published: April 2022

Human apolipoprotein E receptor 2 (APOER2) is a type I transmembrane protein with a large extracellular domain (ECD) and a short cytoplasmic tail. APOER2-ECD contains several ligand-binding domains (LBDs) that are organized into exons with aligning phase junctions, which allows for in-frame exon cassette splicing events. We have identified 25 human APOER2 isoforms from cerebral cortex using gene-specific APOER2 primers, where the majority are exon-skipping events within the N-terminal LBD regions compared with six identified in the heart. APOER2 undergoes proteolytic cleavage in response to ligand binding that releases a C-terminal fragment (CTF) and transcriptionally active intracellular domain (ICD). We tested whether the diversity of human brain-specific APOER2 variants affects APOER2 cleavage. We found isoforms with differing numbers of ligand-binding repeats generated different amounts of CTFs compared with full-length APOER2 (APOER2-FL). Specifically, APOER2 isoforms lacking exons 5–8 (Δex5–8) and lacking exons 4–6 (Δex4–6) generated the highest and lowest amounts of CTF generation, respectively, in response to APOE peptide compared with APOER2-FL. The differential CTF generation of Δex5–8 and Δex4–6 coincides with the proteolytic release of the ICD, which mediates transcriptional activation facilitated by the Mint1 adaptor protein. Functionally, we demonstrated loss of mouseApoer2decreased miniature event frequency in excitatory synapses, which may be because of a decrease in the total number of synapses and/or VAMP2 positive neurons. Lentiviral infection with human APOER2-FL or Δex4–6 isoform inApoer2knockout neurons restored the miniature event frequency but not Δex5–8 isoform. These results suggest that human APOER2 isoforms have differential cleavage events and synaptic properties.

SIGNIFICANCE STATEMENTHumans and mice share virtually the same number of protein-coding genes. However, humans have greater complexity of any higher eukaryotic organisms by encoding multiple protein forms through alternative splicing modifications. Alternative splicing allows pre-mRNAs transcribed from genes to be spliced in different arrangements, producing structurally and functionally distinct protein variants that increase proteomic diversity and are particularly prevalent in the human brain. Here, we identified 25 distinct human APOER2 splice variants from the cerebral cortex using gene-specific APOER2 primers, where the majority are exon-skipping events that exclude N-terminal ligand-binding regions of APOER2. We show that some of the APOER2 variants have differential proteolytic properties in response to APOE ligand and exhibit distinct synaptic properties.
Microorganism-mediated green synthesis of silver nanoparticles using Aspergillus niger and Bacillus megaterium
Authors:   Faculty of Natural Sciences, Quy Nhon University, Vietnam, Hieu H. N. , Trang D. T. H. ,   Faculty of Natural Sciences, Quy Nhon University, Vietnam, Hien V. T. T. ,   Faculty of Natural Sciences, Quy Nhon University, Vietnam, Nghia N. V. ,   Faculty of Natural Sciences, Quy Nhon University, Vietnam, Lam N. T. ,   Faculty of Natural Sciences, Quy Nhon University, Vietnam, Nguyen T. M. D. ,   Faculty of Natural Sciences, Quy Nhon University, Vietnam
Published: April 2022

Research in the field of nanotechnologies, the development of reliable and environmentally friendly processes for the synthesis of metallic nanoparticles constitutes an important element in this field. In this study, biosynthesis of silver nanoparticles using Bacillus megaterium and Aspergillus niger is reported. The results show that the characteristic UV-vis absorbance peak of AgNPs synthesized using Aspergillus niger was observed in the 433 - 448 nm range and around 475 nm with Bacillus megaterium. Most of the particles were spherical in shape and within a size range of 1 to 10.5 nm using Aspergillus niger and 3 to 15 nm with Bacillus megaterium. The FTIR analysis of AgNPs showed five absorbance bands at 3446, 1645, 1373, 1080, and 790 cm−1 . These AgNPs have potential antibacterial activity against Escherichia coli. The results of our study could help to improve the silver nanoparticle synthesis since our method makes them small, stable, and with a high antibacterial efficiency.
Growth and characterization of DL-Norleucine maleate crystals
Authors:   Department of Physics, Sadakathullah Appa College, Tirunelveli, Tamilnadu, India, Bazeera A. Z. , Muthuraj D. ,   Department of Physics, M.D.T.Hindu College, Tirunelveli, Tamilnadu, India, Mohamed A. S. ,   Department of Chemistry, Sadakathullah Appa College, Tirunelveli, Tamilnadu, India, Durai S. C. V. ,   Department of Physics, JP College of Arts & Science, Tenkasi, Tamilnadu, India, Nashrin M. A. ,   Department of Physics, Sadakathullah Appa College, Tirunelveli, Tamilnadu, India, Affiliated to Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli, Tamilnadu, India
Published: April 2022

To obtain the single crystals of DL-Norleucine Maleate (DLNM), slow evaporation solution growth technique was used. The good crystalline quality of the crystal was validated by the diffraction peaks of the Powder X-Ray diffraction techniques. The functional groups which are present in the crystal were validated by FTIR and FT Raman method. Density functional theory (DFT) computation gives optimized structure parameters of DLNM molecule. The compound is changeless thermally up to 160°C and it is illustrated by TG-DTA thermal studies. The composition of the DLNM crystal was studied by EDAX spectroscopy. NMR spectral and chemical shifts of the grown crystal of DLNM were analyzed. The study of Vickers micro hardness study leads to the hardness number (HV) evaluation and work hardening coefficient. Various dielectric parameters like AC conductivity, dielectric constant and loss energy of the sample were determined from the dielectric studies.
Synthesis of CuO/SnO2 NPs on quartz substrate for temperature sensors application
Authors:   Ibn khaldun privte university college -Iraq, Faisal A. D. , Kalef W. K. ,   University of Technology-Iraq, Department of Applied Science, , Baghdad, Iraq, Salim E. T. ,   University of Technology-Iraq, Department of Applied Science, , Baghdad, Iraq, Alsultany F. H. ,   Al-Mustaqbal university collage, Department of Medical Physics, Iraq
Published: April 2022

Temperature sensor of p-CuO/n-SnO2 heterojunction was successfully fabricated and investigated. SnO2 nanostructure was firstly synthesized via chemical vapor deposition. Followed by a top layer of CuO nanoparticles was deposited on SnO2 by drop cast method. The SnO2 film was analyzed via x-ray diffraction (XRD) and scanning electron microscope (SEM). The XRD confirms the formation of the SnO2 nanstructure .The SEM reveals the SnO2 nanoparticles agglomerated together forming a cauliflowers-like nanostructure with a calculated particle size of 17nm. The temperature response corresponding to the relative variation of sensor resistance (ΔR) to a given temperature was measured. It was found that the present sensor has a high sensitivity of 0.56%/°C. Temperature sensor p-CuO/n-SnO2 heterojunction was found to be quite promising material in the temperature range of 25-200⁰ C.
Preparation and synthesis of the nanoferrite Ni0.3Co0.2Zn0.5AlxFe2-xO4 utilizing sol-gel auto-combustion approach
Authors:   Dept. of Physics, College of Science, University of Kirkuk, Kirkuk, Iraq, Munef R. A. , Omar B. A. ,   Dept. of Physics, College of Science, University of Kirkuk, Kirkuk, Iraq, Fathi S. J. ,   Dept. of Physics, College of Science, University of Kirkuk, Kirkuk, Iraq
Published: April 2022

Nanoferrite, which has the chemical structure (Ni0.3Co0.2Zn0.5AlxFe2-xO4), have been produced with the use of the sol-gel auto–combustion approach that have (X=0, 0.1, 0.2, 0.3, 0.4 and 0.5) values. Samples are calcined at a temperature of (1,250oC) for a duration of (2 h), structure characteristics of the ferrite was confirmed by XRD. The results of the XRD have shown that the ferrite that has a size of the grain that ranges between (22 nm and 40 nm) and have a spinal Cubic phase, the x-ray result density (ρx-ray) has been decreased with the content of Al+3 . Electrical properties have shown that the dielectric loss factor and dielectric constant are reduced with an increase in frequency. Conductivity increases as well (σa.c) with the increase in the frequency value.
Deposition of (Ag,Cu)2Zn(Sn,Ge)S4 thin films on Mo-coated glass substrate by vacuum magnetron sputtering and post-sulfurization techniques
Authors:   School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China, Xu J. X. , Tian X. ,   School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China
Published: April 2022

Cation substitution is a useful way to improve the properties of semiconducting Cu2ZnSnS4 thin film. In this work, partial Cu and Sn in Cu2ZnSnS4 are substituted by Ag and Ge, respectively. The (Ag,Cu)2Zn(Sn,Ge)S4 thin films were successfully fabricated using vacuum magnetron sputtering and post-sulfurization techniques. The formation of Ag & Ge co-doped Cu2ZnSnS4 structure with secondary phase is proved by XRD and Raman results. The Ag and Ge ratios depend on the composition of Cu-Ag target and the sputtering time of Ge, respectively. The direct optical band gap values of thin films increase with the increase of Ge content. When the sputtering time of Ge is 90 s, the Urbach energy of (Ag,Cu)2Zn(Sn,Ge)S4 thin films reaches the minimum value of 339 meV, revealing the reduced band tail state by Ge incorporation.
Missing value imputation with linear methods in the database of cardiological patients in prediction of mortality
Authors: Bibicheva Tatiana S. , Skazkina Viktoriia V. , Ogneva Marina V. , Simonyan Margarita A. , Gridnev Vladimir I. , Karavaev Anatoly S.
Published: April 2022

This study examines missing value imputation in the Russian Acute Coronary Syndrome Registry (RusACSR) and assessment of the probability of predicting mortality. Linear methods with the most probable or average value were used for imputation. The prediction problem was solved using the k-nearest neighbors method. This work reveals that the imputation method, despite their simplicity, increases the probability of prediction of mortality by 6%.
Spectral analysis of signals of autonomic regulation of blood circulation in patients with COVID-19 and arterial hypertension
Authors: Skazkina Viktoriia V. , Popov Konstantin A. , Krasikova Natalia S.
Published: April 2022

The work aims to carry out a comparative analysis of the spectral indices of the photoplethysmogram signals and RR-intervals of healthy volunteers, patients with COVID-19, as well as patients with COVID-19 and chronic arterial hypertension of 1-2 degrees. The study included 45 records of pairs of electrocardiogram and photoplethysmogram signals. Each sample included 15 pairs of 20-minute experimental signals. The study revealed an increase in the integrated power of the low-frequency (LF) band over the integrated power of the high-frequency (HF) band in the photoplethysmogram signals in patients with COVID-19, burdened with hypertension. In the signals of the RR-intervals, the largest values of the ratio of the LF to HF indices are associated with patients without cardiovascular diseases. In turn, this may be an indicator of the different effects of viral infection and arterial hypertension on the loops of autonomic control of heart rate and vascular tone.
The Effects of Calina Papaya Leaf Ethanol Extract On Estrus Cycle And Uterus Morphology of Wistar Rats
Authors: Setiawan Haris , Wulandari Sri Wijayanti , Nurwidyantary Fauziana Eka , Dewantari Intan
Published: April 2022

Calina papaya leaf is an Indonesian papaya plant type that has the potential to be used as a medicinal plant. Phytochemical compounds found in papaya leaves act as antifertility agents. The research aimed to study the antifertility effect of Calina papaya leaf ethanol extract on estrus cycle and uterine morphology of wistar rats. The experiment lasted 30 days and involved 25 female wistar rats. The treatment consisted of 5 groups, namely K (distilled water), K+ (contraceptive pill), P1 (Calina papaya leaf ethanol extract 200mg/KgBW), P2 (Calina papaya leaf ethanol extract 300mg/KgBW), and P3 (Calina papaya leaf ethanol extract 400mg/KgBW). The parameters of estrus cycle consisted of estrus cycle phase, total cycle and estrus cycle ratio. Uterus morphological parameters consist of wall thickness of the endometrium, myometrium, and perimetrium. The estrus cycle examination was carried out every day using the vaginal smear method (Giemsa 5%). On the 31st day, surgery was performed and the uterus was taken for histological observation using the paraffin method (HE staining). Data were analyzed using One Way ANOVA with further Duncan’s test. The results showed that a dose of 400 mg/KgBW could affect the estrus cycle with accelerate the estrus phase and increase the estrus cycle ratio compared to the control (P0.05). There was a decrease in endometrium and myometrium wall thickness at a dose of 400 mg/KgBW compared to the control (P0.05). The conclusion of the study is that the ethanol extract of Calina papaya leaves at a dose of 400 mg/KgBW has the potential to be a natural antifertility agent on female wistar rats.
Production Improvement of M1 Generation Garut (Maranta arundinacea) Rhizomes through Gamma Radiation Mutation
Authors: Deswina Puspita , Priadi Dody , Paradisa Yashanti Berlinda , Anggraheni Yuliana Galih Dyan , Mulyaningsih Enung Sri , Perdani Ambar Yuswi , Indrayani Sri
Published: April 2022

Garut (Maranta arundinacea L.) is a tuber containing flour with a low Glycemic Index (IG) suitable for diabetics and other degenerative diseases. It needs to be developed to reduce the dependence on imports or to substitute wheat flour. The objective of the study was to obtain superior arrowroot seedlings and observe the effect of gamma-ray irradiation on the density and position of stomata on arrowroot leaves. In this research, the irradiation of five arrowroot accessions of second-generation (MV1) with gamma rays (0, 10, 20, 30, 40, and 50 Gray) was carried out to obtain mutants with superior character so that they could be used as parent plants for arrowroot flour production. The treatments administered were arrowroot accessions (V), gamma-ray radiation dose (R), and their interaction. The qualitative and quantitative characters on plant characteristics, tuber production, and arrowroot leaves' stomata were observed. The research results showed that increased production is primarily for 25-Pandeglang accession (808.33 grams) and 10 Gray (800.00 grams) of gamma ray radiation treatment. It is expected that this accession can be released as a new variety candidate after subsequent selection and evaluation in a further generation. Moreover, the dose of gamma-ray radiation is inversely proportional to the number of stomata, which will increase the photosynthesis, thus increasing the number of tubers produced.
Morphological Differences between Chaetodon auriga and Chaetodon vagabundus based on Truss Morphometric Characters
Authors: Hadi Rosewitha Anggraeni Privieshanti , Winarni Elly Tuti , Bhagawati Dian , Nuryanto Agus
Published: April 2022

Chaetodon auriga and Chaetodon vagabundus are popular marine aquaria fish from Cahetodontidae family. Both species show subtle morphological variations, especially in juvenile stages, which might lead to misidentification. Additional morphological characteristics, such as truss morphometric, are valuable characters for species identification in Chaetodontidae. This study aimed to evaluate morphological differences between Chaetodon auriga and C. vagabundus based on truss morphometric characters. The study is expected to provide new morphometric characters for Chaetodon auriga and C. vagabundus differentiation on the southern coast of West Java, Indonesia. Fish samples were collected from Ujunggenteng and Taman Manalusu Beach. The specimens were identified based on morphological characteristics and referred to the characters available in the literature. Truss morphometric characters were measured using callipers with an accuracy of 0.01mm and convert to ratio values to obtain constant value. The data were analyzed statistically using the Mann-Whitney test in SPSS software packages. The result showed that five truss morphometric characters were significantly different between C. auriga and C.vagabundus.  This study concluded that C. auriga and C. vagabundus could be differentiated using truss morphometric character. This study provides five new morphometric characters for species differentiation in fish species, especially between C. auriga and C. vagabundus.
Ethnobotanical Studies of Medicinal Plants Used in Managing Diabetes mellitus in Rejang Lebong Districts, Bengkulu - Indonesia
Authors: Rahayu Sri Endarti , Marisa Yusi , Matondang Ikhsan
Published: April 2022

Diabetes mellitus is becoming a major cause of concern throughout the world. Many people, especially in rural communities, use medicinal plants to treat the disease and its complications. This study aimed to document the medicinal plant species used to manage diabetes mellitus and traditional knowledge of local communities in Curup Tengah, Rejang Lebong district, Bengkulu, Indonesia. This study was conducted using a semi-structured questionnaire targeting 32 diabetic patients, and 2 traditional healers. Twenty women (58.8%) and 14 men used medicinal plants to manage the disease. Furthermore, 44 plant species belonging to 34 botanical families were found. The Fabaceae family (9.1%) contributes the highest number of medicinal plant (4 species) followed by Zingiberaceae (3 species) and Asteraceae (2 species). Leaves (38.63%), fruit (18.18%), and seeds (13.36%) were the predominant parts used to prepare the medicine through the extraction method. Documentation of medicinal plants used to treat diabetes as a foundation for subsequent scientific research, with a focus on plants with a high level of informant consensus. Plants with low UV levels, on the other hand, need bioactive screening to confirm their use for the condition. This could be interpreted as a sign of potential plants for the discovery of novel medications. Smallanthus sonchifolius and Anredera cordifolia are reported for the first time as being used in the traditional treatment of diabetes in this study.