bluuebunny/crossref_metadata_2025 huggingface dataset:
The Importance of Drug Safety and the Strategies for Promoting it
Authors: PAPOYAN TATSHAT
Published: June 2024

With medications becoming the standard of treatment for many illnesses these days, drug safety has turned into a high priority in contemporary healthcare. Medicines might offer therapeutic benefits but carry side effects and risks. Drug safety is crucial for positive patient outcome, injury prevention, and lower healthcare expenditures. This particular paper offers a sweeping review of the significance of drug safety and also covers drug development, regulation, surveillance and control of unwanted side effects. The literature review points to the difficulty of drug safety because of patient variables including age, health condition and concurrent medicine. Specific care is required for vulnerable groups - people that are older, kids or even pregnant - who present considerable safety risks. Preclinical testing is informative but clinical trials with human subjects are still crucial for evaluating efficacy and drug safety before marketing. The paper discusses the crucial role of drug safety in public health and also offers views on its intricacy and advancement methods.
Fintech Development Degree in the RA Banking System. Opportunities and Challenges
Authors: GRIGORYAN GRIGOR
Published: June 2024

The development of digital technologies was a great stimulus for the faster
development of a number of areas. The banking sector could not be left out of all of that
where the provision of traditional banking services was gradually replaced by the
provision of remote digital banking services. Most of the banks operating in the world
have already accepted digitization as a challenge and are taking active steps towards
digitization. Newly established banks, which are trying to occupy a place in the market,
mainly provide services remotely through mobile or online banking excluding the
existence of a branch network. All this significantly changes the principles traditional
banking services and the ways of receiving services by clients.
Among digital technologies financial technology stands out which is a rapidly
developing field at the intersection of financial services and advanced technologies. We
can say that it is a powerful engine of technological progress which increases the
global technological influence year by year. It promotes the development of innovative
technologies leading to a new level of speed and flexibility in banking and the field of
information technologies.
In recent years the active development of fintech has also been taking place in the
RA. It brings not only new opportunities but also some risks with it which we will try to
reveal in this work
Banking Stability Multifactor Modelling Using Varma Methodology in the Republic of Armenia
Authors: MINASYAN DAVIT
Published: June 2024

The banking stability modelling with VARMA model has been conducted in the
given research where 48 factors, representing different sectors of economy, have been
selected. After that, by using RIDGE and Lasso regressions, as well as correlation
coefficients with the dependent variable, only the most significant factors have been
chosen. As the determinant of the banking stability, the banking Z-score has been
selected, which is calculated as a country level measure, and not for individual banks.
Using these factors, the VARMA model has been estimated, and the best model is
identified as the VARMA(2,1). It is proven, that factors like Regulatory capital to riskweighted assets, dollarization rate, exchange rates, CPI, profitability of government
bonds, nonperforming loans, ROA, ROC, liquid assets to demand deposits, and other
factors selected in the result of model evaluation are good indicators for modelling the
banking stability.
The model prediction power is tested by splitting data into train and test parts and
comparing predicted values with test dataset. The model shows quite small mean
squared error and proves to be useful for modelling Armenian banking stability with
existing dataset.
Post Pandemic Mental Health and Care Strategies
Authors: Dhillon Rupan
Published: June 2024

This article highlights the changes, pandemic COVID-19 brought along with it. In this phase, people have witnessed huge number of deaths, loss of loved ones and risks with physical health. Of even greater significance is the mental health of the individuals. Apart from boredom in social isolation, they underwent serious symptoms of depression and anxiety. There has been an increase in domestic abuse in the families. Recession and unemployment have led to despair in populations. With no sign of an easy life yet and more drastic changes experienced after the pandemic, people are coping by seeking help of mental health professionals. Revenge tourism and revenge shopping has currently dominated the minds of people and people are seeking wider stimulations after experiencing such a prolonged distress. Therefore, this article will highlight the psychological problems experienced during the COVID times and the mental health of the individuals after the pandemic phase.

Keywords: Revenge tourism, travel, mental health, Integrative care
Development of Teaching Materials Based on Augmented Reality (AR) Digestive System Materials to Improve Creativity and Cognitive Learning Outcomes
Authors: Lestari Utik Puji , Linuwih Suharto , Widiarti Nuni
Published: June 2024

The problem at SD Negeri Ngijo 01 and SD Negeri Mangunsari 01 concerns the lack of technology-based teaching materials and less than optimal learning outcomes in IPAS learning. The formulation of the problem in this research is how to develop, validate and improve student learning outcomes after using Augmented Reality-based teaching materials. This research aims to develop learning media and determine the feasibility and effectiveness of articulate storyline-based E-module media. This research was conducted using the ADDIE model. The ADDIE model consists of five stages: Analysis, Design, Development, Implementation and Evaluation. The study aims to determine the results of the development and effectiveness of articulate storyline-based modules. This research shows that the experts' assessment obtained a median score of very decent criteria with a percentage of 93%. Material experts obtained very appropriate criteria with a rate of 88.8%. Meanwhile, linguists obtained a rate of 100% with very appropriate criteria. The increase in students' cognitive learning outcomes was measured using the N-gain score. The results of the N-Gain test on the pretest and posttest scores obtained an average difference of 39.8 with an n-gain of 0.76 and medium criteria; in the effectiveness interpretation, it received a score of 76.50 with very high criteria. The data description shows that classes that apply Augmented Reality-based teaching materials to science and science subject content achieve more learning outcomes with very effective criteria.

Keywords: IPAS, Sistem Pencernaan, Augmented Reality.
Alternative Media from Mangrove Fruit for the Growth of Shigella dysentery, Escherichia coli, and Salmonella typhi bacteria
Authors: Suwandi Edy , Sari Emilda , Nurhidayatulloh Ariffaldi
Published: June 2024

Objectives: Mangroves are rich in bioactive substances that support bacterial growth. The fruit of the mangrove tree can serve as a valuable source of carbohydrates, making it a potential substitute for Nutrient Agar (NA) as a growth medium.
Methodology and Results: The samples in this study were suspensions of Shigella dysentery, Escherichia coli, and Salmonella typhiwith 16 replications. Thus, the total number of samples in this study was 94 samples. The samples were isolated and identified as colony growth on alternative Mangrove and NA media. The results showed that in alternative media prepared from Mangrove fruit flour, there was a significant growth difference (p-value <0,01) between S. dysentery bacteria with an average of 61 colonies, E. coli bacteria with an average of 2 colonies, and S. typhi bacteria with an average of 2 colonies. The comparison between media of Mangrove and NA also showed a significant growth difference with p-value < 0,01.
Conclusions: Mangrove media has been found to be less conducive to the growth of S. dysentery, E. coli, and S. typhi bacteria, despite being a more cost-effective option compared to NA. Notably, S. dysenteriae bacteria exhibit greater potential for propagation in this medium.

Keywords: Alternative, culture, mangrove, media, nutrient agar
Evaluation of Drinking Water Service Achievement in Tanah Bumbu Regency, South Kalimantan
Authors: Paramitha Dwi Maulidya , Sri Mahreda Emmy , Mahyudin Idiannoor
Published: June 2024

The issues with drinking water services in Tanah Bumbu Regency include the fact that service levels have not yet reached 100% adequacy and 15% safety as outlined in the RPJMN 2024, and the level of water loss remains high. The research aims to evaluate the achievement of drinking water services in Tanah Bumbu Regency, South Kalimantan Province. The study was conducted in Tanah Bumbu Regency, South Kalimantan Province. Sampling for community respondents utilized purposive sampling methods. Sampling for PTAM respondents employed purposive sampling methods, with 11 employees selected from the organizational structure of the office (head of general affairs and personnel; head of technical affairs; and head of each IKK unit). The evaluation results regarding the management of drinking water services in Tanah Bumbu Regency in terms of the 4K aspects (Quality, Quantity, Continuity, and Affordability) indicate that the quality aspect is still suboptimal due to limited funding for health department inspections, resulting in limited water sample collection at household connections. Regarding Quantity, the provision of drinking water services is prioritized in urban areas, while in rural areas, the operator (PTAM Tanah Bumbu) has not been able to meet the needs of the entire population of Tanah Bumbu Regency, both urban and rural, due to production capacity constraints.

Keywords: Evaluation, Drinking water, Tanah Bumbu
Utilizing Machine Learning Techniques for Power Estimation in Residential Electricity Consumption
Authors: Azmi Fadhillah , Saleh Amir
Published: June 2024

Electricity consumption analysis and estimation play a vital role in various contexts, ranging from business planning to household financial management. In an era where electrical energy is a primary source of human activity, understanding power usage patterns and estimating them becomes crucial. This research enables an understanding of energy consumption from individual to national scales and supports efficient energy policy planning. Power estimation provides insights into the expenditures that consumers or companies will incur, enabling effective financial planning. Research and development of accurate predictive models using machine learning techniques are essential to providing useful information for the energy industry and the general public. This study uses machine learning to compare the performance of different power prediction models. The decision tree (DT) method, with an MAE of 0.3613, an MSE of 0.4184, and an RMSE of 0.6469, gives the best results. The results show that the model can provide accurate predictions of electricity consumption, potentially becoming a reliable tool in power management and financial management. Its contribution is crucial in the energy industry and daily life, providing insights needed to enhance energy efficiency and budget management. As a result, this research provides relevant and beneficial solutions to energy and financial management for society and industry.

Keywords: Electricity consumption analysis, Estimation, Machine learning, Power management, financial management
Level of E-health Literacy in Physiotherapy students of Gujarat - A Survey
Authors: Trivedi Shreya
Published: June 2024

INTROCUTION: The skills and ability to access health care resources digitally is understood as E-health literacy. With the increasing use of the internet, digital devices and advancement in health care systems, the ability and need to develop E-health literacy is increased and may have a huge impact on health care providers and health care seekers in the future. This area is not yet explored, and less literature is available, hence the need of study arises. This study was aimed to evaluate the level of E-health literacy in Physiotherapy students of Gujarat. E-health literacy scale (Eheals) is a valid tool to assess the level of E-health literacy among various health care providers.
RESULT: 310 graduate students (83 males, 227 females) across the physiotherapy colleges of Gujarat filled the form and data was analysed using Microsoft excel-Windows 11 version 22H2. 75% students considered that internet is useful and important still the level of confidence to use it was found low among physiotherapy students of Gujarat state.
CONCLUSION: The level of E-health literacy is found moderate to low in Physiotherapy students of Gujarat. There is a vast scope of further studies in this area.

Keywords: E-health literacy, Health, Physiotherapy, Digitalization in health care, health
Capítulo 2. Locución para proyectos sonoros. Dar vida al sonido a través de las cualidades de la voz
Authors: Rodero Emma
Published: June 2024

Este capítulo analiza la importancia crítica de la voz en proyectos sonoros, no solo como un vehículo para transmitir el contenido sino como una herramienta expresiva y persuasiva esencial en la creación de emociones y significados. Las principales cualidades de la voz, como el tono, timbre, intensidad y duración se describen en términos de cómo influyen en la percepción del oyente y en la efectividad comunicativa del mensaje. La intensidad de la voz, medida en decibelios, varía según la presión del aire y es crucial para producir efectos expresivos. La duración afecta la comprensión del mensaje y la atención del oyente, optimizando la velocidad del habla para mantener el interés. El tono, generado por la vibración de las cuerdas vocales, afecta la percepción emocional y la credibilidad; los tonos graves a menudo se perciben como más creíbles y seguros. El timbre, resultante de la anatomía de las cavidades de resonancia, define la singularidad de una voz. La habilidad para manejar estas cualidades es crucial para cualquier locutor porque permite adaptar la expresión y hacer que el mensaje sea más convincente y atractivo. Por eso, un entrenamiento adecuado en estas áreas es indispensable para maximizar la eficacia comunicativa de cualquier proyecto sonoro.
Development of circular supply chain implementation model for MSMEs using extended theory of planned behaviour and DEMATEL approach
Authors: Upadhyay Anjali , Shukla A.C.
Published: June 2024

This study emphasizes circular supply chain management (CSCM) implementation model development for Micro, Small, and Medium enterprises (MSMEs) in the context of India by using the Extended Theory of Planned Behavior (ETPB) and Decision-Making Trial and Evaluation Laboratory (DEMATEL) method of decision making. This study identifies seven factors to develop an extended theory of planned behavior (ETPB) with the help of experts and literature surveys. The DEMATEL method is used to analyze the prominence of factors, interrelationships, and causal relationships between the identified ETPB factors based on experts' opinions. The results indicate that there are three cause factors and the rest four are effect factors. ‘Social Pressure’, ‘Circular Incentives’, and ‘Pro-environmental Behavior and Responsibility’ are the significant causes. The Inbound Supply Chain is the prominent factor affected by all the six factors of ETPB. The research findings will be beneficial for academicians, policymakers, and practitioners as they provide insights into CSCM model development and help in recognizing significant measures to implement it.
Health related Quality of Life of patients with Chronic Kidney Disease undergoing Hemodialysis in National Medical College and Teaching Hospital Birgunj, Province 2, Nepal
Authors: Yadav Rinku , Bhandari Keshav , Sah Shiwani , Singh Richa , Yadav Poonam Kumari
Published: June 2024

INTRODUCTION: Chronic diseases are slow in progression, long in duration and they require medical treatment. The majority of chronic diseases hold the potential to worsen overall health of patients by limiting their capacity to live well, limit the functional status, productivity and health related quality of life (HRQOL) are major contributor to health care costs. And Chronic Kidney Disease (CKD) is also one of them. Assessment of quality of life of patients with Chronic kidney disease not only helps to assess the quality of dialysis program but also is useful to guide nephrologists to develop better interventions and plans of care for the future. OBJECTIVES: This study aimed to assess the quality of life of patient with Chronic kidney disease (CKD) undergoing hemodialysis in National Medical College And Teaching Hospital Birgunj, parsa, Nepal. MATERIAL METHODS: Quantitative descriptive cross sectional study design was adopted for the study. This study was carried out in CKD patients undergoing hemodialysis in dialysis unit of National Medical College, Teaching Hospital with sample size of 79, the instrument CKD patient undergoing hemodialysis. The data were gathered through A semi structured interview schedule was used to collect data. The standardized tool WHOQOL BREF was used, which consists of 26 items. RESULTS: the study finding revealed that the 43% of the respondents had good quality of life, and 57% of respondents had poor quality of life.
CONCLUSIONS: On the basis of study findings; it can be concluded that most of the patient with Chronic Kidney Disease undergoing hemodialysis had poor quality of life in physical (89.9%); psychological (83.5%); social (51.9%) and environmental health (69.6%).
Treatment of the Bitumen and Heavy Oil in Zubair Formation/ East Baghdad Field
Authors: Alhusseini Dr. Ahmed K. , Mohammed Harith A. , Hamzah Sarah H.
Published: June 2024

Bitumen precipitation refers to the separation and settling of heavier, denser hydrocarbon compounds from crude oil, which can occur under certain conditions of pressure and temperature. Crude oils with high viscosity, high density, low API gravity, and high sulfur content are more prone to bitumen precipitation. Understanding these properties is essential in the oil industry for predicting the behavior of crude oils during production, transportation, refining, and storage. The viscosity, density, API, and sulfur content of crude oil were examined as part of this investigation. The viscosity test is achieved by using automated viscometer apparatus with ASTM D 7042 standard, while the sulfur content test is performed by using Sindie 2622 Sulfur Analyzer with ASTM D 7039 standard. However, density and API gravity tests are done depending on manually condition related to mixing, time, method, temperature and percentages until obtained an optimized result. In order to determine the reduction in viscosity and other physical properties of crude oil, which will offer a better solution against the precipitating of asphaltene and Bitumen that essentially lead to plug the production pipe and stop oil production. The chosen solvent was kerosene, which mixed with three samples of crude oil over the course of three periods under standard conditions from the Zubair formation/East Baghdad field [EB-58]. However, the kerosene is selected because it has a high specific gravity which is considered as the best solvent for heavy crude oil and it is inexpensive. Moreover, in experimental work used three percentage of kerosene to mix with crude oil; [6%, 12% and 18%]. The results show that all ratio of kerosene addition will optimize the crude oil properties. The best result was gotten by adding 18 % kerosene to crude oil and the best optimization results were viscosity 89.3%, density 4.27%, API 39.5% and sulfur content 21.2%. In addition to reduce the viscosity of the heavy crude oil, using kerosene for 1 job will minimize the expenses approximately 1,177,000 IQD.
Effect of the Deep Marin Balambo Formation on the Qamchuqa Reservoirs in Jambur Field
Authors: Shwani Ayub Mohammed Ahmed , Qadir Jayran K. , Rahman Shukur A. , Alsaqi Ali S. Alsaqi , Nooralddin Amel K.
Published: June 2024

A shallow-marine carbonate known as Qamchuqa Formation was originally discovered in northern Iraq's Qamchuqa Gorge at an outcrop section. For the present study the available conventional well logs include gamma ray, porosity logs (density, and neutron) with the resistivity logs used to achieve the depositional environment of the studied area in selected wells Ja-21, Ja-32, Ja-41, Ja-46, and Ja-18. The Aptian-Albian age include lower and upper Qamchuqa formations, respectively are considered a major reservoir in Jambur Oil field; therefore, the present study focused only on lower and upper Qamchuqa formations. Deep marine environment Balambo Formation separated the Aptian-Albian reservoir into three parts each part is different in petrophysical properties and lithology composition. Zone -1 is shoal facies including lower and upper Qamchuqa formations composed of dolomite, dolomitic limestone and limestone, this part is far from interfingers with Balambo Formation. Zone -2 is mixed facies between shoal facies and basinal facies composed of limestone, marly limestone,shaly limestone and with a few streaks of dolomitic limestone. This part includes well Ja-32, Ja-41, and Ja-46. Zone -3 basinal facies include Balambo Formation composed of limestone, shaly and marly limestone involving well Ja-18 only. These differences above caused interfingering and lateral change in both reservoir units (lower and upper Qamchuqa formations) with Balambo Formation, and both are not depicting reservoir in Zone -2 and especially in Zone -3. The current study explains well Ja-18 located on the permanent basin and well Ja-32, Ja-41, and Ja-46 located between permanent basin and neritic zone (mixed zone or slope margin); therefore, the south east of Jambur Oil field abandoned to drill in it to Cretaceous age.
Biosynthesis of Fe/Pd Bimetallic Nanoparticles and Used for Removal of Synthetic Oily Wastewater
Authors: Hassan Ahmed Khudhair , Hashim Luay Q. , Rezooqi Ahmed M. , Hashim Mohammed F.
Published: June 2024

Eucalyptus plant leaves aqueous extract was used to produce a green bimetallic Fe/Pd nanoparticles (G-Fe/Pd NPs) catalyst for the degradation of synthetic oily effluent. Using Brunauer-Emmett-Teller (BET) analysis, Fourier-transform infrared spectroscopy (FTIR), particle size, and a zeta potential analyzer, the synthesized G Fe/Pd NPs were evaluated. G-Fe/Pd NPs have been found to contain nanoparticles, with a mean size of 182 nm and a surface area of 5.106 m2/g. The resulting nanoparticles were then used as a catalyst for a Fenton-like reaction. The amount of green catalyst G-Fe/Pd NPs (0.125-0.5 g/L), H2O2 concentration (15-37.5 mmol/L), pH (3-7), and temperature (25-45°C) all have a significant impact on the degradation efficiency of synthetic oily wastewater. Batch experiments showed that 88.9% degraded chemical oxygen demand (COD) from synthetic oily wastewater within the optimum conditions of peroxide concentration, catalyst dose, pH, and temperature which were 30.0 mmol/L, 0.375 g/L, 3, and 45℃ respectively along with 60 min contact time. The results of kinetic models showed that oily wastewater removal followed the Behnajady-Modirshahla-Ghanbary (BMG) model. Finally, the thermodynamic study of the reaction was also examined and concluded to endothermic reaction with an enthalpy of 37.39 kJ/mol.
Optimizing Environmental Parameters with Intelligent Systems to Enhance Prawn Survival
Authors: Adnan Alam Khan
Published: June 2024

This study investigated factors influencing low survival rates of Pacific white shrimp post-larvae (PSL) from hatching to nauplii stage. Particle swarm optimization (PSO) and fuzzy analytic hierarchy process (FAHP) were applied to PSL migration modeling and environmental optimization. PSO simulated nauplii movement towards optimal feeds. FAHP assessed growth based on weighted variables across four ponds. Results demonstrated balancing nutrient diet, temperature, pH, salinity, minerals, and technical pond requirements minimized nauplii distraction and maximized PSL yields. However, birth and mortality imbalances persist, motivating further intelligent optimization to enhance blue economy sustainability and profits. PSO is the only one that can provides the intelligent system about PSL best location, guides about directions, feeds, chemicals and temperature. The proposed system adopts particle PSL characteristics such position, velocity, cost, ideal position, and optimal cost position. The PSL as a particle velocity equation  shows the relationship between particle velocity and the best cost of nature.  The outcome of the system depicts successful PSL. Additional research is needed to elucidate primary causes of nauplii and PSL mortality during early development.
The Impact of Social Capital on Vietnam Rural Economic Development
Authors: Anh Tran Phuong
Published: June 2024

Social capital is always considered as an important resource in the development process. In each nation, social capital shows different characteristics; as a result, these differences create varieties in both styles' lives and social relationships. Usually, social capital is traditionally studied in the sociology field; however, this research will examine it from an economic perspective; and focus to discourse on social capital within the context of economic development in rural areas in Vietnam - a middle-income developing country. Through the author's practical experiences in 6 rural areas in northern Vietnam, combined with in-depth interviews with farmers in these 6 regions and official statistical data from state agencies, the article has synthesized and summarized and pointed out the impact of social capital on Vietnam's rural economic development.
Recurrent cyclops lesion after primary resection of fibroreactive nodue following anterior cruciate ligament reconstruction
Authors: Lee Cadence , Amirouche Farid
Published: June 2024

In this case report featured in World Journal of Orthopedics , Kelmer et al describe a rare finding of a 28-year-old female patient who presented with a recurrent fibroreactive nodule 7 months following the resection of a primary cyclops lesion, suggesting recurrent cyclops syndrome. The patient had undergone an initial anterior cruciate ligament reconstruction for a non-contact right knee injury and reported successful recovery. Two years later, the patient sustained a repeat right knee injury followed by a positive McMurray test and acute pain with terminal extension. Arthroscopic synovectomy confirmed magnetic resonance imaging (MRI) finding of a cyclops lesion, which was surgically removed. Seven months postoperatively, the patient reported stiffness and difficulty with terminal extension. Repeat MRI indicated a recurrent cyclops lesion, which was surgically resected. Following resection of the second lesion, the patient underwent physical therapy and achieved full range of motion, maintaining complete recovery 19 months postoperatively. Recurrent cyclops lesions have rarely been reported in the literature, and this article is novel in its report of recurrent cyclops syndrome following a bone-patellar tendon-bone allograft. The presentation of this unusual finding exposes a need for further investigation of cyclops lesion pathology, which will aid its prevention and treatment.
Advancing orthopaedic trauma care through WhatsApp: An analysis of clinical and non-clinical applications, challenges, and future directions
Authors: Saini Ravi , Jeyaraman Madhan , Jeyaraman Naveen , Jain Vijay Kumar , Ramasubramanian Swaminathan , Iyengar Karthikeyan P
Published: June 2024

The integration of WhatsApp, a widely-used instant messaging application (IMA), into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent years. This paper explores the multifaceted role of WhatsApp in orthopaedics, focusing on its clinical and non-clinical applications, advantages, disadvantages, and future prospects. The study synthesizes findings from various research papers, emphasizing the growing reliance on mobile technology in healthcare. WhatsApp’s role in orthopaedics is notable for its ease of use, real-time communication, and accessibility. Clinically, it facilitates triage, teleconsultation, diagnosis, treatment, patient advice, and post-operative monitoring. Non-clinically, it supports telemedicine, teleradiology, virtual fracture clinics, research, and education in orthopaedic surgery. The application has proven beneficial in enhancing communication among healthcare teams, providing quick responses, and motivating junior physicians. Its use in educational settings has been shown to improve learner’s understanding and patient care. However, the use of WhatsApp in orthopaedics is not without challenges. Risks include the potential spread of misleading information, privacy concerns, and issues with image quality affecting diagnosis and treatment decisions. The paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content accuracy. Looking forward, the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval, improve doctor-patient communication, and address challenges like bureaucratic red tape and limited resources. The paper suggests that future orthopaedic practice, particularly in emergency departments, will increasingly rely on such technologies for efficient patient management. This shift, however, must be approached with an understanding of the ethical, legal, and practical implications of integrating social media and mobile technology in healthcare.
Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus: A systematic review
Authors: Esser Katherine , Butler James J , Roof Mackenzie , Mercer Nathaniel P , Harrington Michael C , Samsonov Alan P , Rosenbaum Andrew J , Kennedy John G
Published: June 2024

BACKGROUND

Cheilectomy of the 1st metatarsophalangeal joint (MTPJ) is one of the most common procedures for the management of hallux rigidus. However, there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy (MIDC) for the management of hallux rigidus.

AIM

To evaluate outcomes following MIDC for the management of hallux rigidus.

METHODS

During November 2023, the PubMed, EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux rigidus.

RESULTS

Six studies were included. In total, 348 patients (370 feet) underwent MIDC for hallux rigidus at a weighted mean follow-up of 37.9 ± 16.5 months. The distribution of patients by Coughlin and Shurna's classification was recorded in 4 studies as follows: I (58 patients, 27.1%), II (112 patients, 52.3%), III (44 patients, 20.6%). Three studies performed an additional 1st MTPJ arthroscopy and debridement following MIDC. Retained intra-articular bone debris was observed in 100% of patients in 1 study. The weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9 ± 3.2 to a postoperative score of 87.1. The complication rate was 8.4%, the most common of which was persistent joint pain and stiffness. Thirty-two failures (8.7%) were observed. Thirty-three secondary procedures (8.9%) were performed at a weighted mean time of 8.6 ± 3.2 months following the index procedure.

CONCLUSION

This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDC for the management of hallux rigidus at short-term follow-up. A moderate re-operation rate at short-term follow-up was recorded. The marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.
Carbamazepine in osteoarthritis treatment: A novel approach targeting Nav1.7 channels
Authors: Vaid Rayyan , Sohail Afra , Amir Nabiha
Published: June 2024

Osteoarthritis (OA) presents a growing health concern, with substantial societal and healthcare burdens. Current management focuses on symptom relief, lacking disease-modifying options. Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment. Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade, offering significant joint protection in animal models. However, human trials are needed to validate these findings. Carbamazepine's repurposing holds promise for OA management, potentially revolutionizing treatment paradigms. Further research is essential to bridge the gap between preclinical evidence and clinical application, offering hope for improved OA management and enhanced patient quality of life.
Understanding the Emergence of Computational Institutional Science: A Review of Computational Modeling of Institutions and Institutional Dynamics
Authors: Oesterling Nicholas , Ambrose Graham , Kim Jiho
Published: June 2024

Computational Institutional Science (CIS) is an emerging stream of social science research performing institutional analysis with computational methods. While such scholarship is garnering increased attention, it draws on many different theories and engages disparate disciplinary backgrounds. Thus, this article provides an overview of CIS articles utilizing agent-based modeling, a computer simulation experiment method, to better understand critical theoretical lenses and topics. More specifically, this article clusters and analyzes 148 articles based on commonalities and differences empirically derived from their overlapping citations (i.e., citation cluster) and abstract content (i.e., topic cluster). Based on our analysis, we discuss the trends observed across cluster types and the overlap between them to better situate CIS inquiry.
Morphological and genetic characterization of Stylophora madagascarensis, Pocillopora acuta, and Pocillopora verrucosa in Mauritius and their thermal photophysiological stress responses
Authors: Jeetun Sruti , Ricot Melanie , Jogee Shakeel Yavan , Kaullysing Deepeeka , Taleb-Hossenkhan Nawsheen , LaJeunesse Todd Christopher , Philippart Grégory , Collard Olivier , Flot Jean-François , Wijayanti Diah Permata , Yucharoen Mathinee , Nascimento Bernardo , Suzuki Yoshimi , Casareto Beatriz Estela , Bhagooli Ranjeet
Published: June 2024

Increasing frequency and intensity of marine heatwaves worldwide warrant characterizing and understanding variation in thermal response among reef corals through in situ and ex situ experimentation to ultimately help with coral conservation and management strategies. This study first characterized species of Pocilloporidae, including two morphs of Stylophora and Pocillopora spp., from the Mauritian waters using morphology and genetics. The photophysiological responses and bleaching sensitivity were then examined when exposed to experimental and natural thermal stress. Pocillopora acuta and Pocillopora verrucosa were identified from Grand Gaube (GG) and harbored a species of Cladocopium (clade C) as their symbiont. The two morphs of Stylophora madagascarensis from Amber Island (AI) and GG were genetically similar and harbored a unique species of Durusdinium (clade D). These pocilloporid taxa exhibited differential bleaching responses during warm water events that occurred in March 2016 and again in 2019. The latter year was characterized by narrower daily variations in sea surface temperature allowing for minimal acclimatization, and possibly explains why bleaching was more severe. Coral nubbins subjected to 28, 30 and 32 °C, and 170 and 10 μ mol quanta m−2 s–1 light levels for a period of 55 hrs revealed variable thermal photo-physiological responses. These findings indicate that the regionally endemic morphotypes of S. madagascarensis are thermally robust and P. acuta tended to be more heat tolerant than P. verrucosa. These results indicate how increasing episodes of thermal stress are likely to affect coral populations in the region and have implications for coral conservation.
The Relationship Between Family Support And Medication Adherence Among Type II Diabetic Patients
Authors: Pakaya Sri Wahyuni , Katili Ansar , Basir Ita Sulistiani
Published: June 2024

Diabetes Mellitus is a chronic metabolic disorder characterized by high bloodsugar levels. Consequently, this condition can cause various problems andcomplications, so patients’ medication adherence is essential to preventcomplications. Apart from that, family support is also a factor that affectsincreasing medication adherence in type 2 DM patients. This research wasclassified as quantitative research using a descriptive correlation method witha Cross-sectional design. The research population was all type 2 DM patientswith complications in the working area of Puskesmas (Public Health Center)Kabila, with as many as 516 people. In the meantime, the samples were 84people determined through Accidental Sampling. The research findingsindicated that 59 respondents (70.2%) had good family support, while 25respondents (29.8%) had poor one. Meanwhile, 48 respondents (57.1%)adhered to taking medication, whereas 36 respondents (42.9%) didnot.Additionally, the results of statistical tests using chi-square denoted a pvalue = 0.000 <?=0.05.In conclusion, there is a relationship between familysupport and medication adherence in type 2 diabetes Mellitus patients withcomplications in the working area of Puskesmas Kabila. Therefore, it isrecommended that this research be used as reference material, and futureresearchers can develop research related to factors affecting medicationadherence.
Kejadian Stunting Pada Balita
Authors: Nurharlinah Nurharlinah , Rosnani Rosnani , Athiutama Ari , Enisah Enisah
Published: June 2024

Sampai saat ini stunting masih menjadi permasalahan global yang dibuktikan dengan tingginya angka kejadian sebesar 21,9%. Stunting terjadi pada anak yang ditandai dengan ketidaksesuaian antara usia dan tinggi badan yang diakibatkan karena kekurangan gizi kronis dan akhirnya menghambat perkembangan fisik serta kognitif anak. Penelitian ini bertujuan untuk mengetahui gambaran kejadian stunting di Wilayah Kerja Puskesmas Palemraya Kabupaten Ogan Ilir. Penelitian ini merupakan penelitian kuantitatif menggunakan pendekatan deskriptif dengan jumlah 655 responden yang dipilih dengan teknik total sampling. Data diambil memakai antropometri untuk mengukur tinggi badan dan kemudian dicatat beserta tanggal lahir pada buku KIA. Analisis data dilakukan secara univariat untuk melihat distribusi frekuensi masing-masing variabel. Hasil penelitian didapatkan bahwa sebagian besar responden berjenis kelamin laki-laki (52,06%), berusia 24-59 bulan (61,53%) dan mayoritas responden tidak mengalami stunting (94,66%). Dari hasil penelitian dapat disimpulkan bahwa terdapat 5,34% anak di Wilayah Kerja Puskesmas Palemraya Kabupaten orang ilir mengalami stunting, hal ini sudah memenuhi target pemerintah terhadap penurunan stunting yakni sebesar 14%.
Zircon Petrochronology of Au-Rich Porphyry and Epithermal Deposits in the Golden Quadrilateral (Apuseni Mountains, Romania)
Authors: Markovic Sava , Brunner Manuel , Müller Lukas , Peytcheva Irena , Guillong Marcel , Chelle-Michou Cyril , Kouzmanov Kalin , Gallhofer Daniela , Heinrich Christoph A. , von Quadt Albrecht
Published: June 2024

The Golden Quadrilateral of the Apuseni Mountains (Romania) represents the richest Au(-Cu-Te) porphyry and epithermal district of Europe and the Western Tethyan metallogenic belt. The Au(-Cu-Te) mineralization is associated with Neogene calc-alkaline magmatism along graben structures growing during the late stages of the Alpine-Carpathian orogeny. We use zircon petrochronology to study the time-space distribution, sources, composition, and timescales of the Au(-Cu-Te)-mineralizing magmatism and explore its link to regional tectonics. Our own and published U-Pb zircon ages document ore-forming magmatic activity between ~13.61 and 7.24 Ma. In combination with available paleomagnetic data, the new zircon ages corroborate the hypothesis that the magmatism in the Golden Quadrilateral evolved in a tectonic environment dominated by major (up to 70°) crustal block rotation. Hafnium isotope composition of Neogene zircon (εHf between –2 and 10) supports the predominant origin of the magmas from a heterogeneous lithospheric mantle, which may have been fertilized during an earlier Cretaceous subduction event and possibly by concurrent Miocene subduction. Xenocrystic zircon shows involvement of crustal sources resembling European continental basement. Fertility indicators, including Eu/Eu* and oxygen fugacity based on zircon composition, show no systematic correlation with the mineralizing events and/or age. High-precision (isotope dilution-thermal ionization mass spectrometry) U-Pb zircon geochronology demonstrates that the magmatic systems exposed at district scale evolved over less than ~100 k.y. and that durations of hydrothermal mineralization pulses were even shorter.
Formation of Topaz-Greisen by a Boiling Fluid: A Case Study from the Sn-W-Li Deposit, Zinnwald/Cínovec
Authors: Qiao Shilei , John Timm , Loges Anselm
Published: June 2024

Zinnwald/Cínovec is one of the largest Li-Sn-W greisen deposits in Europe. Greisens in general are important hosts for many major ore deposits of several high-tech elements—most prominently Sn, W, and Li. However, the mechanisms of greisenization in relationship to ore formation are still not well understood, especially for the important case of fluoride-rich greisen. Here, we investigate the sequence and formation mechanism of the topaz-greisen in the Zinnwald/Cínovec deposit. Based on the mineral abundances, the alteration profile can be divided into four distinct zones: (1) rhyolite, (2) albitite, (3) low-degree greisen, and (4) high-degree greisen. In the greisen zones, almost all the feldspar has been replaced by topaz (up to 12 vol %) + quartz (up to 78 vol %), and the abundance of mica gradually decreases from 11 to 3 vol % with increasing degree of greisenization. Mass balance calculations indicate a net influx of F and silica during greisenization.

Our observations are best explained by a two-stage greisenization process involving phase separation by boiling in the pore space of the sample: first an acidic HF-rich phase, likely a vapor, reacted with feldspar to form topaz and quartz in a dissolution-precipitation reaction. This reaction created substantial transient porosity, which was subsequently sealed by the precipitation of quartz and fluorite from a boiling liquid. We interpret the vapor and liquid as emerging from a common supercritical aqueous parental fluid. The characteristic sequence of creation of pore space by a vapor and the subsequent reduction of porosity by precipitation from the associated boiling liquid constrain the conditions and time available for ore formation. This study evaluates the mechanism of topaz greisenization and the controls on porosity evolution, which are crucial to ore element redistribution.
Sulfide Remobilization in the Metamorphosed Kayad Sedimentary Exhalative Zn-Pb Deposit, Western India: Evidence from Mode of Occurrence, Texture, Hydrothermal Alteration Features, and Trace Element Chemistry
Authors: Das Eileena , Pal Dipak C. , Upadhyay Dewashish , Tripathi Aparajita , Kashyap Vijendra , Meena Kastoor
Published: June 2024

The Kayad Zn-Pb deposit, situated within the Proterozoic Aravalli-Delhi fold belt in western India, is primarily characterized by sphalerite and galena along with pyrrhotite and chalcopyrite. The mineralization occurs as disseminated ores in quartzite, disseminated/laminated and massive ores in quartz-mica schist, and in pegmatite and quartz veins. The laminated ores conform to the regional schistosity and folding, whereas the massive Zn-Pb ores postdate the pervasive tectonic fabric, accumulating at the fold hinges. The massive ore is characterized by durchbewegung texture, discrete blebs of galena and chalcopyrite in a sphalerite matrix with low interfacial angles, and discrete intergrowths of sulfides and sulfosalts such as pyrargyrite, gudmundite, Ag-tetrahedrite, and breithauptite. Geochemical analyses of sulfides reveal microinclusions of sulfosalts comprising Ag, Sb, Cu, Tl, and As, which are regarded as low-melting chalcophile elements (LMCEs). Hydrothermal alteration is insignificant in the laminated and massive ores but prominent around Fe-Cu ± Zn-Pb and Zn-Pb ± Fe-Cu veins. The alteration assemblages in these veins evince a pervasive K + Na ± Fe alteration, later overprinted by a subsidiary Ca ± Na alteration. We interpret the laminated/disseminated ores to be of syndiagenetic sedimentary-exhalative (SedEx) origin formed within an euxinic basin. Conversely, the textural features, mineralogical composition, lack of associated hydrothermal alterations, and evident structural influence on the emplacement of the massive ores suggest they have been remobilized both via plastic flow and by sulfide partial melting. Temperature estimates of up to 650°C, derived from Ti-in-biotite geothermometry of the metamorphosed host rocks, indicate lower-middle amphibolite facies conditions during regional metamorphism. The initiation of melting at these temperatures was promoted by the desulfurization of pyrite to pyrrhotite in quartz-mica schist, aided by melting point depression due to the presence of LMCEs like Ag, Sb, and As.
The Spatial and Temporal Evolution of the Sadisdorf Li-Sn-(W-Cu) Magmatic-Hydrothermal Greisen and Vein System, Eastern Erzgebirge, Germany
Authors: Leopardi Dino , Gutzmer Jens , Lehmann Bernd , Burisch Mathias
Published: June 2024

The Sadisdorf Li-Sn-(W-Cu) prospect in eastern Germany is characterized by vein- and greisen-style mineralization hosted in and around a small granite stock that intruded into a shallow crustal environment. The nature and origin of this mineral system are evaluated in this contribution by a combination of petrography and fluid inclusion studies, complemented by Raman spectroscopy and whole-rock geochemical analyses. The early magmatic-hydrothermal evolution is characterized by a single-phase low-salinity (7.0 ± 4 wt % NaCl equiv), high-temperature (>340°C), CO2-CH4–bearing aqueous fluid, which caused greisen alteration and mineralization within the apical portions of the microgranite porphyry. The bimodal distribution of brine and vapor fluid inclusions, and the formation of a magmatic-hydrothermal breccia associated with the proximal vein mineralization are interpreted to mark the transition from lithostatic to hydrostatic pressure. The vein- and stockwork-style mineralization (main stage) displays lateral zonation, with quartz-cassiterite-wolframite-molybdenite mineral assemblages grading outward into base-metal sulfide-dominated assemblages with increasing distance from the intrusion. Late fluorite-bearing veinlets represent the waning stage in the evolution of the mineral system. The similarity in the homogenization temperature (250°–418°C) of fluid inclusions in quartz, cassiterite, and sphalerite across the Sadisdorf deposit suggests that cooling was not a significant factor in the mineral zonation. Instead, fluid-rock interaction along the fluid path is considered to have controlled this zonation. In contrast to quartz-, cassiterite- and sphalerite-hosted fluid inclusions, which have a salinity of 0.0 to 10.0 wt % NaCl equiv, the fluid inclusions in late fluorite veins that overprint all previous assemblages have a salinity of 0.0 to 3.0 wt % NaCl equiv and homogenize at temperatures of 120° to 270°C, thus indicating cooling with or without admixture of meteoric fluids during the waning stage of the mineral system. The Sadisdorf deposit shares similar characteristics with other deposits in the Erzgebirge region, including a shallow level of emplacement, similar mineralization/alteration styles, and a hydrothermal evolution that includes early-boiling, fluid-rock interaction, and late cooling. In contrast to most systems in the region, both proximal and distal mineralization are well preserved at Sadisdorf. The recognition of such spatial zoning may be a useful criterion for targeting greisen-related Li and Sn resources.