bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Molecular Docking with Network Pharmacology to Reveal the Molecular Mechanism of Simiao Powder in the Treatment of Acute Gouty Arthritis
Authors: Fan Yihua , Liu Wei , Jin Yue , Hou Xu , Zhang Xuewu , Pan Hudan , Lu Hang , Guo Xiaojing
Published: April 2021

Background. The incidence of gout has been rapidly increasing in recent years with the changing of diet. At present, modern medications used in the clinical treatment of gout showed several side effects, such as gastrointestinal damage and the increased risk of cardiovascular disease. The traditional Chinese prescription Simiao Powder (SMP) has a long history in the treatment of acute gouty arthritis (AGA) and has a good curative effect. However, the mechanism and target of its therapeutic effects are still not completely understood. Methods. Potential active compounds (PACs) and targets of SMP were found in the TCMSP database, and the disease target genes related to AGA were obtained by searching CTD, DisGeNET, DrugBank, GeneCards, TTD, OMIM, and PharmGKB disease databases with “acute gouty arthritis” and “Arthritis, Gouty” as keywords, respectively. The network of “Traditional Chinese medicine (TCM)-PACs-potential targets of acute gouty arthritis” was constructed with the Cytoscape 3.7.2 software, and the target genes of acute gouty arthritis were intersected with genes regulated by active compounds of SMP. The resultant common gene targets were input into Cytoscape 3.7.2 software, and the BisoGenet plug-in was used to construct a PPI network. The GO functional enrichment analysis and KEGG pathway enrichment analysis of the intersecting target proteins were performed using R software and corresponding program packages. The molecular docking verification was carried out between the potentially active compounds of SMP and the core target at the same time. Results. 40 active components and 203 targets were identified, of which 95 targets were common targets for the drugs and diseases. GO function enrichment analysis revealed that SMP regulated several biological processes, such as response to lipopolysaccharide and oxidative stress, RNA polymerase II transcription regulator complex, protein kinase complex, and other cellular and molecular processes, including DNA-binding transcription factor binding. Results of KEGG pathway analysis showed that SMP was associated with AGA-related pathways such as interleukin-17 (IL-17), tumor necrosis factor (TNF), p53, and hypoxia-inducible factor 1 (HIF-1) signaling pathways. The results of molecular docking showed that active compounds in SMP exhibited strong binding to five core protein receptors (TP53, FN1, ESR1, CDK2, and HSPA5). Conclusions. Active components of SMP, such as quercetin, kaempferol, wogonin, baicalein, beta-sitosterol, and rutaecarpine, showed therapeutic effects on AGA. These compounds were strongly associated with core target proteins (such as TP53, FN1, ESR1, CDK2, and HSPA5). This study reveals that IL-17, TNF, p53, and HIF-1 signaling pathways mediate the therapeutic effects of SMP on AGA. These findings expand our understanding of the mechanism of SMP in the treatment of AGA.
Association between Low Muscle Mass and Inflammatory Cytokines
Authors: Ito Sadayuki , Nakashima Hiroaki , Ando Kei , Kobayashi Kazuyoshi , Machino Masaaki , Seki Taisuke , Ishizuka Shinya , Fujii Ryosuke , Takegami Yasuhiko , Yamada Hiroya , Ando Yoshitaka , Suzuki Koji , Hasegawa Yukiharu , Imagama Shiro
Published: April 2021

Sarcopenia is a multifaceted geriatric syndrome associated with the loss of muscle mass. We examined the relationship between low muscle mass and inflammatory cytokines in the context of aging. This study involved 299 participants (127 men and 172 women; mean age 63.3 ± 9.8 years) who underwent health checkups for body composition and inflammatory cytokine (TNF‐alpha, IL‐6, and MCP‐1) levels. Muscle mass was determined using the skeletal muscle mass index. We divided the participants into the normal (N) and low muscle mass (L) groups and compared the levels of inflammatory cytokines in nonelderly (<65 years) and elderly (≥65 years) participants. Among the nonelderly subjects, C‐reactive protein was significantly lower in the L group than in the N group (p < 0.05). However, there was no significant difference in the inflammatory cytokine levels between the groups. Among the elderly subjects, the TNF‐alpha level was significantly lower in the L group than in the N group (p < 0.05), whereas there were no significant differences in the IL‐6 and MCP‐1 levels. Moreover, TNF‐alpha was identified as a risk factor for the L group in the logistic regression analysis (Exp (B) 0.935, 95% CI: 0.876–0.997, p = 0.04). Although a low TNF‐alpha level is a risk factor for low muscle mass, inflammatory cytokine levels are not necessarily elevated in elderly individuals with the loss of muscle mass.
MHD Mixed Convection Nanofluid Flow over Convectively Heated Nonlinear due to an Extending Surface with Soret Effect
Authors: Bouslimi Jamel , Abdelhafez M. A. , Abd-Alla A. M. , Abo-Dahab S. M. , Mahmoud K. H.
Published: April 2021

The aim of this paper is to investigate the flow of MHD mixed convection nanofluid flow under nonlinear heated due to an extending surface. The transfer of heat in nanofluid subject to a magnetic field and boundary conditions of convective is studied to obtain the physical meaning of the convection phenomenon. The governing partial differential equations (PDEs) of the boundary layer are reduced to ordinary differential equations (ODEs) considering a technique of the transformation of similarity. The transformed equations are solved numerically considering the technique of an efficient numerical shooting applying the Runge–Kutta technique scheme from the fourth‐fifth order. The results corresponding to the dimensionless speed, temperature, concentration profiles, and the Nusselt number reduced, and the Sherwood numbers are presented by figures to display the physical meaning of the phenomena. A comparison has been made between the obtained results with the previous results obtained by others and agrees with them if the new parameters vanish. The results obtained indicate the impacts of the nondimensional governing parameters, namely, magnetic field parameter M, Soret number Sr, heat source λ, thermal buoyancy parameterλT , and solutal buoyancy parameterλC on the flow, temperature, and concentration profiles being discussed and presented graphically.
Expert Control of Mine Hoist Control System
Authors: Liu Xiuzhi , Sui Tao
Published: April 2021

This paper presents a kind of intelligence control algorithm for the mine hoist control system. Firstly, the desired output of the system is described by a speed curve of hoisting process. Then, the structure diagram of the hoist system is constructed, and the expert PID controller is designed based on the model of this control system; the expert knowledge base was established according to the analysis of characteristics in different periods of the hoist process. Finally, the control effect was verified by SIMULINK simulation; by comparing with the result of conventional PID control, expert PID control is improved more safe and suitable for the mine hoist control system.
Centrality Dependence of Chemical Freeze-Out Parameters and Strangeness Equilibration in RHIC and LHC Energies
Authors: Biswas Deeptak
Published: April 2021

We have estimated centrality variation of chemical freeze-out parameters from yield data at midrapidity of

π

±

,

K

±

and

p

,

p
¯

for collision energies of RHIC (Relativistic Heavy Ion Collider), Beam Energy Scan (RHIC-BES) program, and LHC (Large Hadron Collider). We have considered a simple hadron resonance gas model and employed a formalism involving conserved charges (

B
,
Q
,
S

) of QCD for parameterization. Along with temperature and three chemical potentials (

T
,

μ

B

,

μ

Q

,

μ

S

), a strangeness undersaturation factor (

γ

S

) has been used to incorporate the partial equilibration in the strange sector. Our obtained freeze-out temperature does not vary much with centrality, whereas chemical potentials and

γ

S

seem to have a significant dependence. The strange hadrons are found to deviate from a complete chemical equilibrium at freeze-out at the peripheral collisions. This deviation appears to be more prominent as the collision energy decreases at lower RHIC-BES energies. We have also shown that this departure from equilibrium reduces towards central collisions, and strange particle equilibration may happen after a threshold number of participants in

A

-

A

collision.
Pricing and Safety Investment Decisions in Food Supply Chains with Government Subsidy
Authors: Yu Yanan , He Yong , Salling Melissza
Published: April 2021

As the demand for safe food has been rapidly increasing these years, more and more stakeholders are dedicated to the safety of the food in the supply chain of this sector. To expand the market share of safe food, governments of some countries also provide subsidies to encourage food processors to invest in better food safety efforts. This paper establishes a three-stage game model between the government and a two-stage food supply chain that consists of one supplier and one processor, where the government subsidizes processors to invest in food safety efforts; furthermore, this paper determines the optimal wholesale price, marginal profit, food safety investment, and government subsidies. This paper analyzes the effects of the government subsidies and risk aversion of the food processor and introduces the mode of order quantity-based payment and demand-based payment; moreover, it also analyzes the impacts of subsidies and different payment methods on demands. The results show that suppliers can increase the market share of products by adopting the demand-based payment, but this method does not always benefit the members of the supply chain. As the processor is more risk-averse, the optimal subsidy is higher, encouraging the processor to invest in more efforts. Finally, the supplier’s profit increases with the processor’s risk aversion indicator.
Different Parts of the Chicken Embryo Egg Improve D‐Galactose‐Induced Aging in a Mice Model
Authors: Hong Hsin-Tai , Hsu Tsung-Hsien , Hung Shao-Wen , Chiu Chien-Chao , Wu Chun-Yun , Chen Chia-Chi , Lee Guo-Chi , Lin Jyh-Shiun , Wu Chean-Ping
Published: April 2021

Chick (CE) or duck embryo eggs are known for nutritional supplement foods in traditional East countries for physical fitness enhancement and postpartum conditioning for many years. In this study, we evaluated the effects of different parts of the 10‐day CE (embryo: CEr, yolk: CEw, and chorioallantoic membrane: CEp) on the antifatigue and antiaging activities in a D‐galactose‐ (D‐gal) induced aging mice model. The results showed CEp obviously increased the muscle weight and the liver and muscle glycogen content and enhanced exercise performance. In the antiaging assay, CEp significantly increased the activity of superoxide dismutase (SOD) and Glutathione Peroxidase (GPx). Moreover, the immunohistochemistry results of NRF‐2 and HO‐1 were also detected in the livers of mice in the D‐gal/CEp group. The only partially potential such as CEr might improve OFT function with TG level, and CEw had strange grip strength. Therefore, we suggest that CEp has a potent antifatigue ability and could minimize the occurrence of age‐associated disorders, more than other parts of the 10 days chicken embryo egg.
The New Scramble for Faure Sequence Based on Irrational Numbers
Authors: O. Ali Mogharrabi , V. Behrooz Fathi , Behzadi M. H. , Farnoosh R.
Published: April 2021

This article intends to review quasirandom sequences, especially the Faure sequence to introduce a new version of scrambled of this sequence based on irrational numbers, as follows to prove the success of this version of the random number sequence generator and use it in future calculations. We introduce this scramble of the Faure sequence and show the performance of this sequence in employed numerical codes to obtain successful test integrals. Here, we define a scrambling matrix so that its elements are irrational numbers. In addition, a new form of radical inverse function has been defined, which by combining it with our new matrix, we will have a sequence that not only has a better close uniform distribution than the previous sequences but also is a more accurate and efficient tool in estimating test integrals.
A Secure and Lightweight Three‐Factor Remote User Authentication Protocol for Future IoT Applications
Authors: Taher Bahaa Hussein , Liu Huiyu , Abedi Firas , Lu Hongwei , Yassin Ali A. , Mohammed Alzahraa J.
Published: April 2021

With the booming integration of IoT technology in our daily life applications such as smart industrial, smart city, smart home, smart grid, and healthcare, it is essential to ensure the security and privacy challenges of these systems. Furthermore, time‐critical IoT applications in healthcare require access from external parties (users) to their real‐time private information via wireless communication devices. Therefore, challenges such as user authentication must be addressed in IoT wireless sensor networks (WSNs). In this paper, we propose a secure and lightweight three‐factor (3FA) user authentication protocol based on feature extraction of user biometrics for future IoT WSN applications. The proposed protocol is based on the hash and XOR operations, including (i) a 3‐factor authentication (i.e., smart device, biometrics, and user password); (ii) shared session key; (iii) mutual authentication; and (iv) key freshness. We demonstrate the proposed protocol’s security using the widely accepted Burrows–Abadi–Needham (BAN) logic, Automated Validation of Internet Security Protocols and Applications (AVISPA) simulation tool, and the informal security analysis that demonstrates its other features. In addition, our simulations prove that the proposed protocol is superior to the existing related authentication protocols, in terms of security and functionality features, along with communication and computation overheads. Moreover, the proposed protocol can be utilized efficiently in most of IoT’s WSN applications, such as wireless healthcare sensor networks.
Association between Postural Orthostatic Tachycardia Syndrome and Joint Hypermobility
Authors: Atuesta-Rodriguez Alexis Javier , Medina-Velasquez Yimy F. , Motta Orfa , Narvaez-Reyes Maria Isabel , Rondon-Herrera Federico
Published: April 2021

Joint hypermobility syndrome refers to increased joint flexibility beyond the normal range of motion. This syndrome has a benign form known as Ehlers-Danlos syndrome type 3. This is a disorder in which hypermobility is accompanied by clinical manifestations in the absence of any systemic disease. A clinical finding associated with this condition is postural orthostatic tachycardia syndrome. The following is a rare case of joint hypermobility syndrome and postural orthostatic tachycardia syndrome. The relevance of this case report lies in the impact that this disease had on the patient’s quality of life and the limitation in the performance of activities of daily living.
Biometry, Refractive Errors, and the Results of Cataract Surgery: A Large Sample Study
Authors: Hernández-López Iván , Estradé-Fernández Sahily , Cárdenas-Díaz Taimí , Batista-Leyva Alfo José
Published: April 2021

The statistical characteristics of biometry and refractive error in a large sample of cataractous Cuban patients are presented, comparing between sexes and age groups. All patients were studied at the Cuban Institute of Ophthalmology “Ramón Pando Ferrer,” La Habana. The sample consists of 28252 eyes of 25068 patients, subjected to cataract surgery during the time period between 2006 and 2019. Their biometry was obtained using IOL Master devices; also, visual acuity, refraction, and corneal power were registered. After surgery, the visual acuity and refraction were measured. The refractive prediction error was determined. For patients with both eyes registered, anisometropia was also calculated. Age and sex were used to segment the data. The preoperative biometric parameters show highly significant differences between sexes, with male eyes being longer and with a deeper anterior chamber but with a thinner lens. Also, keratometry shows highly significant differences, with female eyes being steeper than male. Before surgery, both sexes have myopic eyes as average, with males being more myopic than females (

p

 < 0.001). After surgery, the average spherical equivalent is −0.36 D and female eyes are more myopic than males (

p

 < 0.001). Visual acuity with and without distance correction has a significant increase after surgery. These results are of importance not only for Cuba but also for other countries with a large Cuban population and/or similar ethnic composition, such as the USA (particularly the south of Florida), Spain, and many countries in Latin America.
Reducing Skin Toxicities from EGFR Inhibitors with Topical BRAF Inhibitor Therapy
Authors: Lacouture Mario E. , Wainberg Zev A. , Patel Anisha B. , Anadkat Milan J. , Stemmer Salomon M. , Shacham-Shmueli Einat , Medina Egmidio , Zelinger Galit , Shelach Noa , Ribas Antoni
Published: April 2021

Treatment of cancer with EGFR inhibitors is limited by on-target skin toxicities induced by inhibition of the MAPK pathway. BRAF inhibitors are known to paradoxically activate the MAPK downstream of EGFR, which we confirmed using human skin keratinocytes. We then conducted a phase I clinical trial testing the hypothesis that topical therapy with the BRAF inhibitor LUT014 could improve skin toxicities induced by EGFR inhibitors. Ten patients with metastatic colorectal cancer who had developed acneiform rash while being treated with cetuximab or panitumumab were enrolled in three cohorts. LUT014 was well tolerated, and there were no dose-limiting toxicities. The acneiform rash improved in the 6 patients who started with grade 2 rash in the low and intermediate cohorts. We conclude that topical LUT014 is safe and efficacious in improving rash from EGFR inhibitors, consistent with the mechanism of action inducting paradoxical MAPK activation.

Significance:

BRAF inhibitor topical therapy could avoid dose reductions of EGFR inhibitors, locally treating the main dose-limiting skin toxicity of this class of agents.

This article is highlighted in the In This Issue feature, p. 2113
Sparse, Dense, and Attentional Representations for Text Retrieval
Authors: Luan Yi , Eisenstein Jacob , Toutanova Kristina , Collins Michael
Published: April 2021

Dual encoders perform retrieval by encoding documents and queries into dense low-dimensional vectors, scoring each document by its inner product with the query. We investigate the capacity of this architecture relative to sparse bag-of-words models and attentional neural networks. Using both theoretical and empirical analysis, we establish connections between the encoding dimension, the margin between gold and lower-ranked documents, and the document length, suggesting limitations in the capacity of fixed-length encodings to support precise retrieval of long documents. Building on these insights, we propose a simple neural model that combines the efficiency of dual encoders with some of the expressiveness of more costly attentional architectures, and explore sparse-dense hybrids to capitalize on the precision of sparse retrieval. These models outperform strong alternatives in large-scale retrieval.
Adaptive Semiparametric Language Models
Authors: Yogatama Dani , de Masson d’Autume Cyprien , Kong Lingpeng
Published: April 2021

We present a language model that combines a large parametric neural network (i.e., a transformer) with a non-parametric episodic memory component in an integrated architecture. Our model uses extended short-term context by caching local hidden states—similar to transformer-XL—and global long-term memory by retrieving a set of nearest neighbor tokens at each timestep. We design a gating function to adaptively combine multiple information sources to make a prediction. This mechanism allows the model to use either local context, short-term memory, or long-term memory (or any combination of them) on an ad hoc basis depending on the context. Experiments on word-based and character-based language modeling datasets demonstrate the efficacy of our proposed method compared to strong baselines.
Unsupervised Learning of KB Queries in Task-Oriented Dialogs
Authors: Raghu Dinesh , Gupta Nikhil , Mausam
Published: April 2021

Task-oriented dialog (TOD) systems often need to formulate knowledge base (KB) queries corresponding to the user intent and use the query results to generate system responses. Existing approaches require dialog datasets to explicitly annotate these KB queries—these annotations can be time consuming, and expensive. In response, we define the novel problems of predicting the KB query and training the dialog agent, without explicit KB query annotation. For query prediction, we propose a reinforcement learning (RL) baseline, which rewards the generation of those queries whose KB results cover the entities mentioned in subsequent dialog. Further analysis reveals that correlation among query attributes in KB can significantly confuse memory augmented policy optimization (MAPO), an existing state of the art RL agent.

To address this, we improve the MAPO baseline with simple but important modifications suited to our task. To train the full TOD system for our setting, we propose a pipelined approach: it independently predicts when to make a KB query (query position predictor), then predicts a KB query at the predicted position (query predictor), and uses the results of predicted query in subsequent dialog (next response predictor). Overall, our work proposes first solutions to our novel problem, and our analysis highlights the research challenges in training TOD systems without query annotation.
A Computational Framework for Slang Generation
Authors: Sun Zhewei , Zemel Richard , Xu Yang
Published: April 2021

Slang is a common type of informal language, but its flexible nature and paucity of data resources present challenges for existing natural language systems. We take an initial step toward machine generation of slang by developing a framework that models the speaker’s word choice in slang context. Our framework encodes novel slang meaning by relating the conventional and slang senses of a word while incorporating syntactic and contextual knowledge in slang usage. We construct the framework using a combination of probabilistic inference and neural contrastive learning. We perform rigorous evaluations on three slang dictionaries and show that our approach not only outperforms state-of-the-art language models, but also better predicts the historical emergence of slang word usages from 1960s to 2000s. We interpret the proposed models and find that the contrastively learned semantic space is sensitive to the similarities between slang and conventional senses of words. Our work creates opportunities for the automated generation and interpretation of informal language.
Prohibition of Bottom Trawling on Extended Continental Shelves: Creeping Jurisdiction or Enforcement of Sovereign Rights?
Authors: Antsygina Ekaterina
Published: April 2021

This article discusses whether the regime of the continental shelf includes a right to conserve living natural resources and whether a unilateral establishment of a ban on bottom trawl fishing is possible on the high seas superjacent the extended continental shelf (ECS). Based on Article 77 and Part XII of the United Nations Convention on the Law of the Sea, coastal States can impose reasonable conservation measures to protect sedentary species from harmful fishing practices. The article also explores how the competing rights of coastal and flag States, as well rights of coastal States with overlapping ECS entitlements, should be balanced in case of the imposition of unilateral conservation measures.
The recently proposed odonatan ‘suborder’ Cephalozygoptera: fact or fiction

Authors: NEL ANDRÉ , ZHENG DARAN
Published: April 2021

The new ‘suborder’ Cephalozygoptera was recently proposed for three fossil families of damselfly-like Odonata, on the basis of three characters of the head. Here we show, thanks to counter-examples of the presence of these characters in compression fossils of genuine Zygoptera, that these ‘characters’ do not exist in reality but are due to deformations and compression of the heads, a very frequent phenomenon in the fossil record of the whole superorder Odonatoptera. Furthermore, these alleged characters would have to have been regarded as symplesiomorphies, insufficient to support a new clade. Consequently, we consider the Cephalozygoptera as unfounded, to be rejected in the current state of knowledge. A new phylogenetic analysis of the whole clade Panodonata would be welcome. We also discuss the position of some previously described fossils: the Paleocene genus Valerea is restored in the Epallagidae (Euphaeidae), and the two Burmese amber genera Electrodysagrion and Palaeodysagrion are restored in the family Dysagrionidae.
7. The Anatomist Curate
Authors: Yeandle David
Published: April 2021

This chapter documents Hunt’s time at St Botolph’s, Aldgate (1863–64), where he got into trouble over his clandestine dissection of a foetus in the crypt of the church, and the ensuing scandal made the national press, including the Spectator and Punch (6). He was dismissed from this curacy, and his prospects looked bleak.
8. Country Life
Authors: Yeandle David
Published: April 2021

This chapter documents a brief interlude in Swallow, Lincolnshire (1864), where Hunt held a temporary curacy (7) and wrote the first part of Clergymen Made Scarce.
10. Conclusions
Authors: Yeandle David
Published: April 2021

This chapter sums up Hunt’s time as a curate and its significance in the context of the Victorian Church.
Characteristics of people on long-acting injectable antipsychotics in Australia: Data from the 2010 National Survey of High Impact Psychosis
Authors: Suetani Shuichi , Siskind Dan , Phillipou Andrea , Waterreus Anna , Morgan Vera A , Castle David
Published: April 2021

Objective:

This study investigates (1) the proportion of people with psychosis who are on long-acting injectable antipsychotics; (2) the difference in the demographic, clinical, substance use and adverse drug reaction profiles of people taking long-acting injectables compared to oral antipsychotics; and (3) the differences in the same profiles of those on first-generation antipsychotic versus second-generation antipsychotic long-acting injectables.

Methods:

Data were collected as part of the Survey of High Impact Psychosis. For this study, participants with diagnoses of schizophrenia or schizoaffective disorder who were on any antipsychotic medication were included ( N = 1049).

Results:

Nearly a third (31.5%) of people with psychosis were on long-acting injectables, of whom 49.7% were on first-generation antipsychotic long-acting injectables and 47.9% were on second-generation antipsychotic long-acting injectables. This contrasts with oral antipsychotics where there was a higher utilisation of second-generation antipsychotics (86.3%). Of note, compared to those on the oral formulation, people on long-acting injectables were almost four times more likely to be under a community treatment order. Furthermore, people on long-acting injectables were more likely to have a longer duration of illness, reduced degree of insight, increased cognitive impairment as well as poor personal and social functioning. They also reported more adverse drug reactions. Compared to those on first-generation antipsychotic long-acting injectables, people on SGA long-acting injectables were younger and had had a shorter duration of illness. They were also more likely to experience dizziness and increased weight, but less likely to experience muscle stiffness or tenseness.

Conclusion:

Long-acting injectable use in Australia is associated with higher rates of community treatment order use, as well as poorer insight, personal and social performance, and greater cognitive impairment. While long-acting injectables may have the potential to improve the prognosis of people with psychosis, a better understanding of the choices behind the utilisation of long-acting injectable treatment in Australia is urgently needed.
Tobacco smoking and mental disorders in Australian adolescents
Authors: Lawrence David , Johnson Sarah E , Mitrou Francis , Lawn Sharon , Sawyer Michael
Published: April 2021

Objectives:

This study aimed to (1) examine the strength of the association between mental disorders/mental health problems, risk behaviours and tobacco smoking among Australian adolescents, (2) compare rates of tobacco smoking among Australian adolescents with major depressive disorder, attention-deficit/hyperactivity disorder and/or conduct disorder in 2013/14 vs 1998, and (3) identify the extent to which an association between tobacco smoking and mental health problems among adolescents can be attributed to non-mental health risk factors.

Methods:

The study utilised data from the first (1998) and second (2013/14) child and adolescent components of the National Surveys of Mental Health and Wellbeing. Both surveys identified nationally representative samples of Australian young people aged 4–17 years, living in private dwellings. Information was collected from parents and 13- to 17-year-olds about mental disorders, mental health problems, risk behaviours and tobacco smoking.

Results:

In the 2013/14 survey, the rate of current tobacco smoking among those with a mental disorder was 20% compared to 5% in those without a mental disorder. Rates were highest for young people with conduct disorder (50%), major depressive disorder (24%) and anxiety disorders (19%). In 2013/14, 38% of current tobacco smokers had a mental disorder and 32% reported self-harm and/or suicidal ideation vs 10% and 5%, respectively, among adolescents who had never smoked. Females with mental disorders or reporting self-harm or suicidal ideation had higher rates of current smoking than males. Other significant factors associated with current smoking included school-related problems, binge eating and having had more than one sexual partner.

Conclusion:

While smoking rates in 13- to 17-year-olds with mental disorders had declined since 1998, the strength of the association between mental disorders and smoking had increased, especially among females. Our findings highlight the need to address the tobacco smoking among adolescents with mental disorders, particularly females.
The Special Education Teacher Pipeline: Teacher Preparation, Workforce Entry, and Retention
Authors: Theobald Roddy J. , Goldhaber Dan D. , Naito Natsumi , Stein Marcy L.
Published: April 2021

We used data on the student teaching placements, degrees, teaching credentials, and workforce outcomes of more than 1,300 graduates of special education teacher education programs in Washington to provide a descriptive portrait of specific measures of special education teacher preparation and their relationships with workforce entry and early-career retention. Although rates of workforce entry and retention for these special education candidates were high, we documented considerably lower rates of entry into and retention in special education teaching positions for candidates who hold a dual endorsement in special education and another subject. These patterns have potential implications for the state’s new dual-endorsement requirement and for dual-licensure programs more broadly. Student teaching with a cooperating teacher who is endorsed in special education was also associated with a higher likelihood of becoming a special education teacher, even when controlling for whether the placement was in a special or general education setting.
A Bayesian Regression Analysis of the Effects of Alert Presence and Scenario Criticality on Automated Vehicle Takeover Performance
Authors: Alambeigi Hananeh , McDonald Anthony D.
Published: April 2021

Objective

This study investigates the impact of silent and alerted failures on driver performance across two levels of scenario criticality during automated vehicle transitions of control.

Background

Recent analyses of automated vehicle crashes show that many crashes occur after a transition of control or a silent automation failure. A substantial amount of research has been dedicated to investigating the impact of various factors on drivers’ responses, but silent failures and their interactions with scenario criticality are understudied.

Method

A driving simulator study was conducted comparing scenario criticality, alert presence, and two driving scenarios. Bayesian regression models and Fisher’s exact tests were used to investigate the impact of alert and scenario criticality on takeover performance.

Results

The results show that silent failures increase takeover times and the intensity of posttakeover maximum accelerations and decrease the posttakeover minimum time-to-collision. While the predicted average impact of silent failures on takeover time was practically low, the effects on minimum time-to-collision and maximum accelerations were safety-significant. The analysis of posttakeover control interaction effects shows that the effect of alert presence differs by the scenario criticality

Conclusion

Although the impact of the absence of an alert on takeover performance was less than that of scenario criticality, silent failures seem to play a substantial role—by leading to an unsafe maneuver—in critical automated vehicle takeovers.

Application

Understanding the implications of silent failure on driver’s takeover performance can benefit the assessment of automated vehicles’ safety and provide guidance for fail-safe system designs.
Understanding the evolution of open government data research: towards open data sustainability and smartness
Authors: Gao Yingying , Janssen Marijn , Zhang Congcong
Published: April 2021

The past decade has witnessed a rapid development of open government data practices and academic research. However, there is no systematic survey of existing research to understand the evolution of open government data. Such research can facilitate knowledge transfer within and across domains, and foster learning for countries in the early stages of open government data development. This study quantitively extracted the evolution trajectory of open government data based on the main path analysis method and then analysed the underlying motivations. The results show that open government data research went through four main phases and that the open government data movement has spread towards developing countries and smart cities. Different challenges and issues faced by the researchers in each phase drove the evolution of open government data research. Finally, we discuss future directions of open government data research based on our findings and recent development. There is a tendency to create sustainable open government data and smartness by employing artificial intelligence and creating data marketplaces.

Points for practitioners

Open government data efforts have evolved over the years into a global phenomenon. Countries have learned from each other and more and more efforts are focused on innovating with open government data by stimulating co-creation and using other incentives. The way that data are opened should focus on achieving goals like innovation, participation, transparency and accountability. There is a tendency to create sustainable open government data and smartness by employing artificial intelligence and creating data marketplaces.
The “Idea Advantage”: How Content Sharing Strategies Impact Engagement in Online Learning Platforms
Authors: Narang Unnati , Yadav Manjit S. , Rindfleisch Aric
Published: April 2021

In recent years, online learning platforms (e.g., Coursera, edX) have experienced massive growth and have reached nearly 200 million learners. Although their reach is quite large, the impact of these platforms is constrained by a low level of learner engagement. In traditional face-to-face classrooms, educators aim to engage learners by asking them to participate in class discussions and share information about their identity and ideas. However, the effectiveness of these strategies in online learning platforms is uncertain. The authors examine this issue by assessing the impact of two different types of content sharing on learner engagement. The authors conduct a textual analysis of over 12,000 text postings during an 18-month period (Study 1) and a field experiment among over 2,000 learners (Study 2) in a popular Coursera offering by a large U.S. university. The results indicate that asking learners to share ideas (vs. their identity) has a stronger effect on their video consumption and assessment completion. The authors explain this “idea advantage” by suggesting that learners who share ideas (vs. identity) exhibit a greater degree of elaboration. This idea advantage is strongest for learners from English-speaking countries and those new to online learning.
Association between fluoroquinolone utilization rates and susceptibilities of gram-negative bacilli: Results from an 8-year intervention by an antibiotic stewardship program in an inner-city United States hospital
Authors: Zeana Cosmina , Palmieri Frank E. , Gupta Vikas , Ye Gang , Lao Peter , Yu Kalvin , Kang Kyoung-Sil , Schiller Larry , Purswani Murli
Published: April 2021

This study evaluated an antibiotic stewardship program (ASP) intervention aimed at reducing inpatient fluoroquinolone (FQ) use and examined its impact on ciprofloxacin susceptibilities of gram-negative bacteria in a large 611-bed community hospital. A two-step ASP intervention was implemented: an electronic medical record algorithm that prompted physicians to re-evaluate FQ use shortly after admission and changed institutional UTI/pneumonia guidelines that recommended options alternate to FQs for first-line empiric antibiotic therapy in 2010 and 2011 respectively. Between 2007 and 2017 FQ use and ciprofloxacin susceptibilities of all non-duplicate cultured isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa obtained ≥72 h after admission were reviewed. Ambulatory care isolates served as a comparison group. FQ utilization rates and relationships to ciprofloxacin susceptibility were evaluated using interrupted time series models. Over the 11-year period, FQ use decreased from 110.0 (2007) to 26.2 (2017) days of therapy/1000 days at risk ( p < 0.001). Compared to pre-intervention, the estimated (post-intervention) reduction in FQ utilization was 28.4 (95% CI: 10.9–46) days of therapy/1000 days at risk. Reduced FQ utilization was correlated with increase susceptibilities to ciprofloxacin of hospital onset isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis ( p < 0.02), and Pseudomonas aeruginosa ( p = 0.07). No significant susceptibility change was observed in the ambulatory care isolates. Persuasive interventions by an ASP successfully modified physicians’ inpatient empiric antibiotic use, produced a sustained reduction in FQ utilization rates and increased ciprofloxacin susceptibility to four commonly encountered gram-negative bacteria in a community hospital.
Thermodynamic properties of cotton dyeing with indigo dyes in non-aqueous media of liquid paraffin and D5
Authors: Fan Jie , Shao Min , Miao Junhua , Ma Junran , Hu Mingan , An Yuan , Shao Jianzhong
Published: April 2021

On the basis of investigation into the dyeing equilibrium of cotton fibers with indigo dyes in decamethylcyclopentasiloxane (D5), liquid paraffin and water, the thermodynamic properties of cotton dyeing with indigo dyes in non-aqueous medium systems were studied in comparison with aqueous dyeing. The main works involved are as follows: firstly, the adsorption isotherms were created; then, the three theoretical adsorption models of Nernst, Langmuir and Freundlich were used to fit the adsorption isotherms created; finally, the thermodynamic parameters were calculated. The results showed that the adsorption isotherms were all in line with the Freundlich model. The order of dyeing affinity was in the sequence: liquid paraffin > D5 > water. The dyeing entropy in the three media showed positive values, which is mainly attributed to the adsorption of both indigo-leuco and water onto cotton fibers, thus reducing the ice-like structure formed among the water molecules in the dyeing system and the hydrophobic bonding structure formed among the non-aqueous medium molecules, then leading to an increase in the system disorder. The dyeing heat in the three media also showed positive values, due mainly to the absorption of thermal energy to “melt” the ice-like structure and to “break” the hydrophobic bonding structure. These dyeing thermodynamic properties are conducive to understanding and interpreting the dyeing performance and behavior of indigo dyes in non-aqueous dyeing systems.
Civil–Military Relations and Human Rights
Authors: Bell Sam R. , Clay K. Chad , Kiyani Ghashia , Murdie Amanda
Published: April 2021

Do civil–military relations influence human rights practices? Building on principal–agent theory, we argue that civilian–military relations, instead of having an effect on mean levels of repression, will be associated with the dispersion in human rights practices. States where there is less control of the military or more conflict between civilian and military leadership will see a wider range of human rights practices. We test our hypotheses quantitatively on a global sample of countries, using updated data on civil–military relations and find evidence that civil–military conflict and lack of control increase the variance in human right practices.
Goon Squad Democracy? The Rise of Vigilant Citizenship through Victim Support and Neighborhood Watches in Amsterdam (1980-1990)
Authors: De Jong Wim
Published: April 2021

This paper analyses the rise of a new kind of urban citizenship in the context of the urban crisis of the 1980s: the vigilant citizen, characterized by a view of citizens as possible victims, who assume and are called upon to take responsibility for social safety. Top-down policy explanations insufficiently clarify why the polarized debate over urban petty crime developed into a consensus by the mid-1980s. Tying in with recent trends in urban police history, this paper shows the diversity of bottom-up actors in Amsterdam that helped to, sometimes unintentionally, further a communitarian “social safety” agenda: vigilantes and victim-support groups, the former based in more conservative circles, the latter partly inspired by women advocacy groups. These actors entered into a sometimes-tense dynamic with the police and municipality, which took up the challenge of providing victim support and of educating the public for neighborhood prevention. This slowly yielded results.
The deep organisation: The organisational view in a public management and leadership development programme
Authors: Knudsen Morten , Larsson Magnus
Published: April 2021

This article studies the organisational view inherent in a public management and leadership development programme. Organisational views are important to study as they guide and frame the actions of the members of the organisation. In the management and leadership development programme under investigation the organisational view was a linguistic-discursive representation that was empirically inept, but which nevertheless was offered as a guide to the managers. Inspired by Clifford Geertz’s notion of religion we suggest conceptualising the presented organisational view as the deep organisation. The analysis contributes to the literature on public management and leadership development programmes by calling attention to the implicit concepts of organisation that on the one hand provide managers with the motivation and authority to carry out their daily ordering of the constantly fluctuating empirical organisation, while to some extent making managers immune to experience-based learning on the other. The notion of the deep organisation expands our understanding of the layered nature of assumptions about organisations, through which seeming contradictions can be handled. In the discussion we outline three important implications of the analysed organisational view.
Work, play, and precariousness: An overview of the labour ecosystem of esports
Authors: Johnson Mark R , Woodcock Jamie
Published: April 2021

Professionalised competitive digital gaming or ‘esports’ has grown to a point where millions of dollars are being awarded in competitions watched globally by tens of millions of viewers. Previous analyses of the phenomenon have examined the role(s) of labour in esports performed by various actors – players, tournament organisers, sponsors, game developers – but these have yet to be unified into a ‘big picture’ of esports labour, especially when considering the relationships between the labour performed by different esports actors. In this paper we therefore present a comprehensive overview of the labour that different actors within the emerging Esports ecosystem perform, and how they intersect and influence each other in order to contribute to the existence of this highly contemporary phenomenon. In doing so we show that the rapid growth of Esports has created new labour processes and forms of work, transformed existing ones, yielded new career options, and tremendous profits to be made by a range of involved actors. Esports’ emerging position as a major global industry both within gaming and within contemporary media more broadly demands close attention to its work, its workers, and who is winning and losing in this dynamic media space.
Anatomy of a precarious newsroom: precarity and agency in Syrian exiled journalism in Turkey
Authors: Badran Yazan , Smets Kevin
Published: April 2021

This paper contributes to the ongoing debate on the precarisation of journalistic work by looking at the case of Syrian exiled journalists in Turkey, whose professional and personal lifeworlds are underpinned by multiple layers of precarity. The article builds on data collected during a 3-month-long period of participant observations at the newsroom of Enab Baladi, a Syrian news outlet based in Istanbul, Turkey. It develops a relational notion of precarity through insights from the growing body of work on precarity in the journalistic field, as well as research on precarity and migration. It proposes a multidimensional understanding of the ‘precarious newsroom’ that takes into account the people, organisation and place, as a way to map how different layers of precarity, and responses to them, are articulated, experienced and negotiated. Our research underlines the complex anatomy of the precarious newsroom as a paradoxical place and an amalgamation of precarity and agency.