bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia—UK Nationwide Multicenter Assessment
Authors: Lawrence Neil Richard , Bacila Irina , Dawson Jeremy , Mahdi Sundus , Alvi Sabah , Cheetham Timothy D , Crowne Elizabeth , Das Urmi , Dattani Mehul Tulsidas , Davies Justin H , Gevers Evelien , Krone Ruth E , Patel Leena , Randell Tabitha , Ryan Fiona J , Keevil Brian , Ahmed S Faisal , Krone Nils P
Published: July 2023

Context

Quality of life (QoL) has been inconsistently reported in children and young people (CYP) with congenital adrenal hyperplasia (CAH).

Objective

Assess QoL in CYP with CAH in the UK alongside biometric and androgen profiles.

Design

To define the evidence base for health care delivery, we conducted a cross-sectional study in CYP with CAH in the UK. Questionnaire results were compared with normative data and between groups, and modelled for association with sex, height, weight, body mass index, or steroid biomarkers of CAH control.

Setting

Tertiary care in 14 UK centers.

Patients

Results from 104 patients, 55% female, mean age 12.7 years (SD 3.0), paired responses from parents.

Interventions

Strengths and Difficulties questionnaire (SDQ) and pediatric QoL questionnaire.

Main Outcome Measure

Total QoL scores as assessed by SDQ and a pediatric QoL questionnaire in comparison to normative data.

Results

Total scores were worse in parents than normative data, but similar in patients. Patient QoL was rated better in social functioning but worse in emotional, school, and peer domains by patients, and worse in total scores and domains of peer problems, and psychosocial, emotional, and school functioning by parents. Parents consistently scored QoL of their children lower than their child. Larger height-SD score and lower weight-SD score were associated with better QoL. Girls with lower steroid biomarkers had worse SDQ scores.

Conclusions

In CYP with CAH, reduced height, increased weight, and hormonal biomarkers consistent with overtreatment were associated with worse QoL; addressing these problems should be prioritized in clinical management.

Clinical Trials Registration Number: SCH/15/088
Leptin, but not Estradiol, Signaling in PACAP Neurons Modulates Puberty Onset
Authors: Evans Maggie C , Wallace Elliot G , Ancel Caroline M , Anderson Greg M
Published: July 2023

The adipose-derived hormone leptin critically modulates reproductive function, such that its absence results in hypothalamic hypogonadism. Pituitary adenylate cyclase-activating polypeptide (PACAP)-expressing neurons are potential mediators of leptin's action on the neuroendocrine reproductive axis because they are leptin-sensitive and involved in both feeding behavior and reproductive function. In the complete absence of PACAP, male and female mice exhibit metabolic and reproductive abnormalities, yet there is some sexual dimorphism in the reproductive impairments. We tested whether PACAP neurons play a critical and/or sufficient role in mediating leptin's effects on reproductive function by generating PACAP-specific leptin receptor (LepR) knockout and rescue mice, respectively. We also generated PACAP-specific estrogen receptor alpha knockout mice to determine whether estradiol-dependent regulation of PACAP was critically involved in the control of reproductive function and whether it contributed to the sexually dimorphic effects of PACAP. We showed that LepR signaling in PACAP neurons is critically involved in the timing of female, but not male, puberty onset, but not fertility. Rescuing LepR-PACAP signaling in otherwise LepR-deficient mice was unable to rescue the reproductive deficits observed in LepR null mice but led to a marginal improvement in body weight and adiposity in females. Finally, PACAP-specific estrogen receptor alpha knockout did not lead to any changes in body weight or puberty onset compared with control mice. These data highlight that PACAP is a critical mediator of some of leptin's, but not estradiol's, influence on puberty onset in females, but is not critically involved in relaying leptin's effects in males or in adult females.
Primary Sellar Neuroblastoma Masquerading as a Pituitary Macroadenoma
Authors: Seshan Nandini , Hanft Simon , Goswami Gayotri , Syal Arjun
Published: July 2023

Olfactory neuroblastomas, or esthesioneuroblastomas, are rare and aggressive malignant tumors that typically arise from the olfactory neuroepithelium in the upper nasal cavity. In rare instances, they can be ectopic originating from areas outside the upper nasal cavity such as the sellar region. These tumors, also known as primary sellar neuroblastomas, may be mistaken for pituitary macroadenomas. We present a rare case of a primary sellar neuroblastoma in a 30-year-old woman with a prior diagnosis of presumed prolactinoma, status post transsphenoidal resection, with residual visual deficits, who presented with worsening vision and headaches. Pituitary magnetic resonance imaging showed a large sellar mass causing compression of the optic chiasm, and invasion of the right cavernous sinus and bilateral cavernous internal carotid arteries. The patient underwent a second transsphenoidal resection. Postoperatively, she developed central adrenal insufficiency, central hypothyroidism, central hypogonadism, and transient syndrome of inappropriate antidiuretic hormone secretion. Owing to rapid tumor regrowth, she underwent a craniotomy with plans for radiation treatment. This condition is challenging to diagnose and has poorly defined clinical management guidelines. An early, aggressive approach with surgical intervention is recommended.
Comparison of clinical efficacy and safety between interventional embolization and craniotomy clipping for anterior circulation aneurysms
Authors: Lei Bo , You Guoliang , Wan Xiaoqiang , Wu Honggang , Zheng Niandong
Published: July 2023

Objective: To investigate the clinical efficacy and safety of interventional embolization in the treatment of anterior circulation aneurysms.

Methods: Eighty patients with anterior circulation aneurysms admitted to People’s Hospital of Leshan from June 2019 to December 2021 were retrospectively analyzed. According to the different surgical methods, they were divided into two groups: the observation group and the control group. Patients in the observation group were given interventional embolization, while those in the control group were given craniotomy clipping. The surgical efficacy, postoperative neurological function and quality of life, surgical prognosis and surgical complications of the two groups were compared.

Results: The intraoperative blood loss and hospitalization time in the observation group were lower than those in the control group (p<0.05). The scores of the Hunt-Hess and modified Rankin scale in the observation group were significantly lower than those in the control group three months after surgery (p<0.05). The good prognosis rate of the observation group was higher than that of the control group (p<0.05). Moreover, the complication rate of the observation group was 12.50%, which was significantly lower than 32.50% in the control group (p<0.05).

Conclusion: Interventional embolization shows the advantages of minimally invasive procedures such as shorter operative times and shorter hospital stays. It has better clinical safety because it can significantly improve the neurological function and quality of life of patients, improve the prognosis of patients, and reduce the incidence of complications.

doi: https://doi.org/10.12669/pjms.39.5.7092

How to cite this: Lei B, You G, Wan X, Wu H, Zheng N. Comparison of clinical efficacy and safety between interventional embolization and craniotomy clipping for anterior circulation aneurysms. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7092

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Association of plasma folic acid, vitamin-B12 and homocysteine with recurrent pregnancy loss. “A case control study”
Authors: Afaq Erum , Ali Anwar , Jamil Rabia , Waseem Hira Fatima
Published: July 2023

Objective: To investigate the relationship of serum homocysteine, folic acid, and vitamin-B12 levels with recurrent pregnancy loss (RPL).

Methods: A case-control study was conducted in the Department of Gynecology and Obstetrics, Dr. Ruth Pfau Civil Hospital, Karachi from July 2021 to June 2022. Total 124 participants were recruited from gynecology outpatient department after taking informed consent. The participants included 62 females with two or more consecutive unexplained RPLs and 62 healthy women having at least two successful deliveries without any pregnancy loss. Serum folic acid and vitamin-B12 levels were measured by chemiluminescent method and serum homocysteine was measured by enzyme-linked immunosorbent assay (ELISA). Comparison of quantitative variables with RPL cases and control was done by Mann-Whitney U-test (for non-normally distributed data) and independent sample t-test (for normally distributed data), while Pearson’s chi-square test was used for the association of qualitative variables with RPL cases and control. Correlation of homocysteine with vitamin-B12 and folic acid was assessed in RPL cases.

Results: The median age of the study population was 27 (IQR 25-32) years. The median body mass index (BMI) was 26.25 (IQR 22-29) kg/m2. Cases had significantly lower serum folic acid (p-value=0.022), while vitamin-B12 was decreased in cases as compared to controls (p-value=0.295). Mean concentration of serum homocysteine was higher in RPL cases as compared to controls (p-value=0.094). There was significant association of serum vitamin B12 (p-value=0.001) and folic acid levels (p-value=0.004) with RPL. The homocysteine was not significantly correlated with vitamin-B12 (r=0.124, p=0.338) and folic acid (r=0.067, p=0.606) in the RPL group.

Conclusion: Reduced level of serum folic acid and vitamin B12 was significantly associated with RPL cases, while homocysteine was marginally raised however the difference was not significant. Folic acid and vitamin B12 supplementation before next pregnancy in RPL patients is likely to be beneficial in improving pregnancy outcomes.

doi: https://doi.org/10.12669/pjms.39.5.7432

How to cite this: Afaq E, Ali A, Jamil R, Waseem HF. Association of plasma folic acid, vitamin-B12 and homocysteine with recurrent pregnancy loss. “A case control study”. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7432

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sovereignty as an environmental practice: the problem of territoriality and anthropocentrism
Authors: Walewicz Piotr
Published: July 2023

The article is a theoretical study of state sovereignty. By looking at the concept in a different way from traditional methods, it tries to discern whether sovereignty is necessarily antithetical to a sustainable world. Emphasis is put on its territoriality and anthropocentrism – both of which make it into a major obstacle when tackling global and transnational environmental problems. State sovereignty is analyzed as an environmental practice of the state, which allows for the control of resources to be used by capital. The analysis is conducted using theoretical and conceptual critique as the main method. It is based on various sources ranging from critical geopolitics and critical geography to political science and political ecology, including the concept of Capitalocene.

As long as sovereignty remains utilized by the state in service to capital, it will be used to cement its ability to control space and extract resources. However, a different kind of sovereignty is imaginable and therefore the institution itself is neither friend nor enemy to environmental politics. This new understanding of sovereignty opens up new avenues for theoretical research in political ecology and International Relations, bridging the gap between traditional state-centric approaches and the transboundary nature of ecological problems.
The genome sequence of the Brindled Beauty, Lycia hirtaria (Clerck, 1759)
Authors: Boyes Douglas , Holland Peter W.H. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: July 2023

We present a genome assembly from an individual male Lycia hirtaria (the Brindled Beauty; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence is 552.0 megabases in span. Most of the assembly is scaffolded into 14 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.58 kilobases in length.
A PROTOTYPE DESIGN OF A DEDICATED SMART HOME ENERGY MANAGEMENT SYSTEM
Authors: Al-Naima Fawzi M , Kareem Hassanain H
Published: July 2023

With the continuous rise of electrical energy costs for heating, cooling, and ventilation and the increasing number of energy-consuming home appliances, designing a cost-effective efficient residential electric energy management system has become crucial. This paper presents a prototype simulated design of a Smart Home Energy Management System (SHEMS), dedicated to the management of residential electrical energy according to the user-preassigned comfort requirements and cost criteria. All planted sensors and home appliances are controlled by one master microcontroller. The Proteus Software ISIS was used for all simulation results.  The proposed application collects information from sensors to control the required home appliances by switching them ON or OFF based on a specified design algorithm. The sensors' assigned values and home appliance status are stored in a main database. The proposed design also allows home appliances to be monitored and controlled remotely via the Internet. Simulated results are given for a two-room residential home.
FOOD SECURITY ISSUES IN COVID-19 PANDEMIC AND ITS PARTICULARITIES IN GEORGIA
Authors: Arnania-Kepuladze Tamila , Kepuladze Giorgi
Published: July 2023

Insurance stable food security was and remains, one of the most significant issues faced by human society. Food security is an important socioeconomic and political issue at the individual, national, and global levels. In the conditions of global cataclysms like the COVID-19 pandemic, the problem of food security becomes even more difficult. As mentioned at the opening of the Joint Technical Symposium held on December 16th, 2022, “There is no certainty when the next pandemic will strike us, but there is the absolute certainty that it will happen again”. In such conditions, rethinking the gained experience obtained through the COVID-19 pandemic becomes particularly important. The article distinguished two aspects of food security – the food quantity problem and the food quality problem and considers the impact of COVID-19 on food security at the levels of countries, human groups, and economic sectors. On the country level, the paper discusses countries that experienced food problems in the past, food-import-dependent countries, and food-export-dependent countries. On the human groups level, the article distinguishes communities and groups of people who already experienced hunger, socially unprotected populations, and the so-called "new poor". On the economic level, the paper defines sectors of the economy that were highly affected by the COVID-19 pandemic. It also analyses the food security issues in Georgia and the effects of COVID-19 on the domestic production of main groups of products, the ratio of import and export by groups of products, and the self-sufficiency ratio according to some groups of products.
BLOCKCHAIN TECHNOLOGY AND APPLICATION – SMEs ASPECT
Authors: Cekerevac Zoran P , Cekerevac Petar Z
Published: July 2023

This review article is designed for SME owners and directors to understand better what blockchains are and how they work and to support them to start an entirely new blockchain or fork an existing one and create a new token. The article presents technology bases and how blockchains can serve SMEs and foreseeable challenges that could jeopardize the achieved results. Particular attention the authors paid to blockchain applications, transaction cost reduction, and sensitive business information security. Even more attention the authors gave to the challenges connected with digital infrastructures and business practices, investments, lack of interoperability, lack of skills, and legal aspects. Chapter four discusses the creation of blockchains for SMEs from the aspects of choosing a type of blockchain, choosing of consensus mechanism, a platform selection, nodes design, operating systems, instances design, application programming interfaces, and user interfaces, and the blockchain finalizing. In chapter five, Conclusions, the authors draw conclusions based on the work presented in the article.
ALLEVIATING POVERTY THROUGH ENTREPRENEURSHIP: HOMO ENTREPRENEUR, ENTREPRENEURIAL CULTURE, AND STATE
Authors: Bogdanovic Mario
Published: July 2023

Creating economic well-being considers entrepreneurship as a basic factor. Improving entrepreneurship improves economic well-being/wealth at all levels of aggregation: individual, family, social community, state, and world civilization. Improving entrepreneurship means applying knowledge and understanding its causal factors. It is essentially a psychological, socio-cultural, and political-economic phenomenon. As a psychological/mental phenomenon, it can be recognized in individual conative (value), emotional-motivational, intellectual, and behavioral characteristics of people who start businesses (characteristics of enterprising persons/homo entrepreneur). As a social/cultural phenomenon, entrepreneurship recognizes social attitudes and behavior (culture), manifested as a mentality as a key success ingredient. As a political-economic phenomenon, it recognizes the importance of the political-economic situation, that is, in the actual resource support of state institutions, the absence of obstacles/disincentives for entrepreneurs, and in economic policies, practices, and habits that stimulate entrepreneurial ventures and economic growth. The results of the discussion about the individual, socio-cultural, and political-economic characteristics necessary for an entrepreneurial (creative) society have several outcomes.   In the context of poverty alleviation, there is indicated the necessity of cultivating/internalizing: a) specific characteristics of entrepreneurs that make up an entrepreneurial person/homo entrepreneur, b) specific entrepreneurial values - cultural characteristics that form an entrepreneurial culture/mentality, and c) specific political-economic entrepreneurship prone characteristics/behavior of the state (state institutions) that form an entrepreneurial state. In such a context, management solutions for entrepreneurial/economic development improvement should suggest an integral strategy for poverty alleviation. Such a strategy should have different levels of aggregation from the individual to the global civilization of the human species.
DEVELOPMENT AND ECONOMIC EFFICIENCY OF THE RECLAMATION INDUSTRY IN THE REPUBLIC OF TATARSTAN
Authors: Hismatullin Mars , Valiev Ayrat , Khismatullin Marsel , Asadullin Nail , Mikhaylova Valerikovna
Published: July 2023

Sustainable and efficient production of agricultural products, regardless of the influence of weather and climate factors in the zone of risky farming, is largely possible only with the widespread introduction of land reclamation measures. The research was carried out with the aim of studying the current state of the reclamation industry in the Republic of Tatarstan and developing scientifically based ways of its development. In the course of the studies of the economic efficiency of irrigated agriculture in the republic, it was found that in potatoes production due to irrigation, the yield increases from 3.89 to 4.2 times, and the marketability of finished products due to improved quality and standardization of tubers by 2.58 times. It was revealed that with a potato marketability of 80%, the net income per 1 ha is 495.9 thousand rubles. The net income from 1 ha of corn for silage under irrigation is 52.4 thousand rubles. This suggests that one ruble spent on irrigation allows farms to receive up to 12 rubles of additional production in the production of grain crops. And in the production of vegetables and marketable potatoes - up to 40 rubles. The cultivation of perennial crops on irrigation makes it possible to obtain up to four full-fledged cuttings, which makes it possible to provide the livestock industry with a reliable fodder base. At this stage of development of the reclamation industry of the Republic of Tatarstan, about 1.5% of the arable land of the Republic is under irrigation reclamation, it produces up to 18.5% of the gross crop production. However, the widespread introduction of land reclamation elements by agricultural producers is limited due to a number of reasons. This series includes: the high cost of restoration, construction, operation and maintenance of reclamation facilities and their network, the lack of technical and financial resources for agricultural enterprises, the need for preliminary costly survey and design work to obtain design estimates (DED). According to expert estimates, to provide food for the inhabitants of the Republic of Tatarstan, it is necessary to have at least 150 thousand hectares of irrigated land, against the currently available 35 thousand hectares. Achieving the indicated value of irrigated lands is not possible without the adoption of a comprehensive program for the development of melioration and agrolandscape farming system, which should be adequately financially secured for the implementation of program activities.
THE NATURE AND STRENGTH OF THE CORRELATION OF SPRING WHEAT YIELD WITH SOIL FACTORS IN CONDITIONS OF GRAY FOREST SOIL
Authors: Serzhanova Al'bina , Gilyazov Minnegali , Shaykhutdinov Farit , Serzhanov Igor , Daminova Anisa
Published: July 2023

The study was carried out in order to assess the dependence of the yield of spring soft wheat on the main agrochemical indicators and spring reserves of productive moisture in a meter layer of gray forest soil. The work was carried out in 1982-2018. in the Kama zone of the Republic of Tatarstan. Spring wheat was cultivated in the crop rotation link: pure fallow - winter rye - spring wheat. Under the predecessor, the average recommended norms of mineral fertilizers (N40 ... 60P40 ... 50K40 ... 60) were annually introduced; fertilizers were not applied directly under the wheat. The soil of the experimental plot is gray forest medium loamy with the following agrochemical parameters: organic matter content - 2.8 ... 3.2%, easily hydrolyzable nitrogen - 100 ... 149 mg / kg, mobile phosphorus and potassium (according to Kirsanov). ) - 105...184 and 79...149 mg/kg, respectively, pHrast. – 5.6...5.7. The yield of spring wheat cultivated without fertilization varied greatly over the years and ranged from 0.99 to 2.97 t/ha. It amounted to 62% due to the influence of the provision of gray forest soil with the main nutrient macronutrients (NMC) in a form available to plants. The content of readily hydrolysable nitrogen 150 mg/kg, mobile forms of phosphorus and potassium 150 and 140 mg/kg, respectively, turned out to be the optimal level for the formation of the largest grain yield of spring wheat in the experiment on gray forest soil. without the use of fertilizers.
Precisos manejos y progresos del arte del toreo
Authors: Daza Josef
Published: July 2023

La obra taurina de Josef Daza, varilarguero, rejoneador y picador del siglo XVIII, constituye uno de sus principales legados. Organizada en dos tomos, se presenta esta edición modernizada realizada directamente de los ejemplares conservados en la Biblioteca del Palacio Real y adaptada a los usos ortográficos actuales. En ella se percibe cómo el autor recurre a la escritura no solo como un medio para evocar y difundir su testimonio profesional taurino, sino fundamentalmente para redimir a la tauromaquia de sus detractores. Para ello, esgrime argumentos, datos y un considerable número de autoridades y maestros. De esta manera, su obra contribuye a clarificar ese periodo del siglo XVIII, considerado de tránsito, entre el repliegue del toreo caballeresco y la institucionalización del toreo a pie.
Críticos con el atomismo mecanicista: Ostwald, Mach y Duhem.
Authors: Álvarez Fernández Alberto
Published: July 2023

Wilhelm Ostwald, Ernst Mach y Pierre Duhem se encuentran entre los más relevantes críticos del atomismo de finales del siglo XIX. Repasamos y analizamos los argumentos que aducen dichos autores para oponerse a la concepción atomista de la materia. Mostramos cómo esos argumentos surgen de posiciones filosóficas de fondo sobre el fundamento de la naturaleza, el objeto de la ciencia y el papel de la metafísica. Comparamos dichas posiciones filosóficas. Y enmarcamos la crítica del atomismo en el problema epistemológico más general de la explicación para mostrar la tensión entre explicación y experiencia, y su relación con la metafísica.
Arithmetical Certainties: A Few Exceptions Among Countless Knowledge-Statements.
Authors: Ariso José María
Published: July 2023

En este artículo discrepo de Kusch (2016) en tres cuestiones relacionadas con las expresiones de certezas aritméticas –en el sentido de Wittgenstein– y los usos regulares de las expresiones aritméticas. Específicamente, explico por qué los cálculos no se convierten en certezas por el hecho de haber sido probados; Argumento que los cálculos probados constituyen enunciados de conocimiento; y, por último, pero no menos importante, concluyo de esto que tales cálculos probados son decibles, mientras que las certezas aritméticas son inefables o indecibles.
Interpretación de las nociones de transindividualidad e interindividualidad en Gilbert Simondon.
Authors: Berlaffa Cenzano Mateo
Published: July 2023

En este artículo nos proponemos pensar acerca de las nociones simondonianas de interindividualidad y transindividualidad con el fin de reconsiderar las diferencias psicosociales en los modos de relacionarnos. Para ello, presentamos a modo esquemático algunos elementos fundamentales de la obra de Simondon que nos ayudarán para el desarrollo de ambos conceptos, dialogando a su vez con ideas de otros autores de gran utilidad.
Univocité, infinité et transcendance divine chez Marin Mersenne.
Authors: Basilico Brenda Verónica
Published: July 2023

Cet article a pour but principal de déterminer la façon dont le modèle de rationalité mathématique de Marin Mersenne (1588-1648) pourrait conduire nécessairement à l'univocité. Il s’agit de savoir si les humains connaissent-ils, par exemple, le théorème de Pythagore de la même façon que Dieu le fait. Pour répondre à cette question, nous abordons la notion de vérité comme conformitas dans son dédoublement théologique et épistémologique. Ensuite, nous nous concentrons sur le concept des possibles en tant qu’objet des mathématiques et de l’entendement divin. En dernier lieu, nous interpellons la thèse d’une univocité radicale soutenue par Jean-Luc Marion pour finalement exposer nos conclusions.
El humanismo bestial contra las bestias: Un acercamiento teórico-filosófico al problema de los animales.
Authors: Pérez Hernández Aylén
Published: July 2023

Desde la tradición humanista occidental se ha instituido una oposición radical entre el ser humano y el animal no-humano en tanto dos regímenes de existencia diferentes e irreconciliables; oposición que ha partido, esencialmente, de una construcción ficcional del hombre y de lo “propiamente humano” como especie superior y dominante respecto al resto de los vivientes. Dicho fenómeno, o fabulación, ha venido aparejado, además, de un proceso de no reconocimiento de la animalidad que habita en el hombre y de la urgencia por suprimir tales rasgos como si se tratase de una dimensión inaceptable de la existencia humana. El artículo examina, entonces, algunos de aquellos rasgos del paradigma humanista occidental que han delineado relaciones binarias y especistas en el mundo contemporáneo y que han negado lo animal en la búsqueda de lo “propiamente humano”. El trabajo hace un breve recorrido por algunas de las hipótesis que han abordado, desde diversos posicionamientos, la problemática de los animales: Berger, Descartes, Sloterdijk, Agamben, Derrida y Bailly son algunos de los aludidos. En ese sentido, el ensayo explora determinados tópicos teóricos, entre los que se encuentran: el animal-máquina cartesiano, las civilizaciones como invernaderos antropogénicos, la máquina antropocéntrica y la riqueza de mundo de lo animal.
En attendant l’Europe: crisis migratoria y los límites de la condición postfotográfica.
Authors: Gómez Masdeu Alejandro
Published: July 2023

El concepto de postfotografía es uno de los más fértiles que ha dado la estética contemporánea. En el presente artículo pretendemos estudiar la posible participación de las poblaciones migrantes en la condición postfotográfica. Igualmente, comentaremos desde la teoría de la postfotografía tres imágenes y obras audiovisuales ligadas a la migración en el siglo XXI. A través de ellas, se mostrará la posible aplicación del concepto de postfotografía a obras relacionadas con la migración. Asimismo, a partir de ellas creemos poder localizar algunos límites a lo postfotográfico y a su potencialidad política.
Un problema metafísico en la filosofía de Catharine Trotter Cockburn: el espacio, el alma y la jerarquía de seres.
Authors: Calvente Sofía Beatriz
Published: July 2023

La metafísica de Catharine Trotter Cockburn disuelve la relación necesaria entre inmaterialidad, inmortalidad y pensamiento. Mientras que en su juventud esto la lleva a admitir la posibilidad de la materia pensante, en su madurez le permite concebir al espacio como sustancia inmaterial no pensante que oficia como eslabón entre la sustancia material no pensante y la sustancia inmaterial pensante. Para ello, apela también a la tesis de la gran cadena del ser. Sin embargo, la posibilidad de la materia pensante no es consistente con la tesis de la jerarquía de seres, porque en ella la materia ocupa el lugar más bajo. Me propongo estudiar si existe alguna alternativa dentro de la filosofía de Trotter que permita resolver esta contradicción.
El sujeto: Hades y Cerbero. Una reflexión sobre el giro espacial en la filosofía.
Authors: Campillos Morón Luis Ángel
Published: July 2023

Presentamos una reflexión en torno al llamado giro espacial en la filosofía. En primer lugar, enmarcaremos la problemática general y analizaremos el viejo paradigma de carácter trascendente e idealista. Presentaremos a éste como el Hades. Después caracterizaremos sus tres pilares fundamentales con las tres cabezas de su guardián Cerbero. Contra la identidad, el individualismo y la jerarquía vertical, la nueva concepción del espacio se basa en la diferencia, en la comunidad y en otras semióticas
Los rostros de un estado delegado. Religiosos, indígenas y comerciantes en el Putumayo, 1845-1904
Authors: Mongua Calderón Camilo
Published: July 2023

En la frontera amazónica entre Colombia y Ecuador,comerciantes y religiosos lideraron el desarrollo, el éxito y el fracaso de losproyectos estatales durante la segunda mitad del siglo XIX. De igual modo,jugaron un papel clave en tanto incorporaron a la población indígena al difícilproceso de consolidación del Estado colombiano en el Putumayo. Al tiempo quedefendían sus intereses, estos actores tomaron parte en las disputasfronterizas con los países vecinos. Con su presencia y acciones, los tresgrupos sostuvieron, de distintos modos, las pretensiones de Colombia enterritorio amazónico. Mediante el estudio de fuentes documentales inéditas, elautor ofrece una mirada renovada de la historia del Putumayo, superando laslecturas centradas en la "ausencia del estado" y en la extracción dela quina y el caucho.
Entomologia Forense: Análise da Produção Científica no Brasil
Authors: De Freitas Thamyres Borges , Caetano Rebecca Leal , Barbosa Júlio Vianna , Carriço Cesar , Pinto Zeneida Teixeira
Published: July 2023

A Entomologia Forense é uma ciência que aplica o estudo dos insetos a métodos legais, sendo utilizada como evidência física nas perícias, podendo ser usadas em causas cíveis e causas criminais. As evidências encontradas nos insetos podem mostrar muito sobre o que aconteceu na cena do crime, como: a causa da morte, a estimativa do intervalo pós-morte (PMI), alguma mudança na posição do corpo etc. O objetivo deste estudo foi analisar a produção científica nacional no que diz respeito à Entomologia Forense no Google Acadêmico em dez anos, no período de 2008 a 2018. Para a busca dos artigos foram usados os seguintes descritores: entomologia forense, insetos necrófagos, fauna cadavérica e/ou ciência forense. Nestes estudos foram gerados dados sobre as características dos artigos sobre a entomologia forense, sobre a sucessão dos artrópodes na carcaça/cadáver, sobre o grupo de artrópodes mais utilizados como tema de estudo, e os estados do Brasil onde foram desenvolvidos os estudos. Os resultados mostraram um total de 49 artigos sobre a entomologia forense no período analisado, o ano que mais publicou sobre o assunto foi em 2015 com sete artigos, e o de menor foi o ano de 2011 com um artigo. Os periódicos com maior número de publicações foram: EntomoBrasilis com 7, Revista Brasileira de Entomologia e Revista Brasileira de Criminalística com 4, e a Revista Iheringia com três publicações durante esse período. A ordem Diptera foi a que teve maior representação no total dos grupos de artrópodes estudados, seguida pela Ordem Coleoptera.
Saúde mental e o cuidado à população LGBTQIAPN+: orientação sexual e diversidade de gênero como determinantes sociais da saúde.
Authors: Silva Luan Layzon Souza , Leite Junior Francisco Francinete , Nascimento Isaac Marlon Vasconcelos do
Published: July 2023

A partir do entendimento que orientação sexual é o caminho do desejo e gênero é o papel social de ser mulher, homem ou outro, ambos componentes dos corpos e identidades, é possível compreender, com base nos determinantes de saúde, que a LGBTQIAPN+fobia interfere no processo saúde-doença, causando sofrimento e adoecimento. O Estado Brasileiro reconheceu as questões de orientação sexual e gênero como determinantes da saúde a partir de discussões realizadas na 13ª Conferência Nacional de Saúde e expressamente na Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais. Com o objetivo de analisar as possíveis interferências das questões de orientação sexual e gênero na efetivação do acesso e do cuidado da população LGBTQIAPN+ nos serviços de saúde mental do município de Iguatu/CE, foi realizada, uma pesquisa qualitativa e exploratória, sendo a pesquisa-ação a técnica principal de coleta de dados, tendo sido produzidas oficinas com trabalhadores da saúde nos três Centros de Atenção Psicossocial - CAPS no município, contando com participação de 27 profissionais. Essas oficinas tiveram a finalidade de problematizar três pontos específicos a partir das perspectivas dos participantes: os conceitos de orientação sexual e gênero; a saúde da população LGBTQIAPN+; e as questões do preconceito, do acesso e do cuidado da população LGBTQIAPN+ nos serviços de saúde mental. Após, foi realizada uma análise de discurso. Conclui-se que o acesso é fragilizado, ameaçando a universalização do SUS e o cuidado é precário, diante do sofrimento, preconceito, invisibilização e falta de informação, limitando o cuidado integral e equanime.
Baixo peso ao nascer associado a fatores de risco maternos e neonatais
Authors: Carvalho Rillary Maria De Sousa , Oliveira Maria Auxiliadora Silva
Published: July 2023

O baixo peso ao nascer (BPN) é definido por um peso menor a 2.500 gramas em recém-nascidos. Ele se associa a prematuridade e/ou restrição do crescimento intrauterino, sendo fator determinante para complicações neonatais. Sendo assim, a presente pesquisa avaliou o perfil obstétrico e neonatal de recém-nascidos com baixo peso ao nascer e de suas genitoras atendidos na maternidade Santa Casa de Misericórdia de Sobral (SCMS). A pesquisa foi realizada através de um estudo documental, retrospectivo, quantitativo e descritivo, realizado em uma maternidade pública referência no Norte do estado do Ceará. A pesquisa foi aprovada pelo comitê de ética da Universidade Estadual do Vale do Acaraú. A partir disso, foram avaliadas 1.101 declarações de nascidos vivos registradas no ano de 2015. Desse total, foram incluídos 300 prontuários (n=300) de recém-nascidos com BPN buscando variáveis obstétricas e neonatais como idade materna, idade gestacional no nascimento, número de consultas pré-natal e índice de Apgar.  Após coleta dos dados, as informações foram alocadas em tabelas para posterior análise. Através da interpretação dos resultados foi evidenciado que a região norte do Ceará apresenta um alto índice de recém-nascidos com BPN, podendo estar associado a prematuridade, gravidez na adolescência e número de consultas pré-natal inferior ao recomendado. Como complicação, apresentam baixos índices de Apgar. Logo, se faz necessário medidas governamentais de planejamento familiar, melhor assistência pré-natal e maior disponibilidade de insumos para prevenção e tratamento de recém-nascidos com BPN.
A Petrobras e as mudanças climáticas
Authors: Costa Heitor Scalambrini
Published: July 2023

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Editorial
Authors: Camello Thereza Cristina Ferreira
Published: July 2023

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Health check
Authors: Costis Rachel
Published: July 2023

In a new series of columns penned by senior health visitors, Rachel Costis, operational manager for public health nursing at Swindon Borough Council, sets out key safeguarding lessons from two recent child deaths: Arthur Labinjo-Hughes and Star Hobson
Let's go to… The Whitworth, Manchester
Authors: Turner Lucy
Published: July 2023

Today we are exploring things which roll, says Lucy Turner, producer for the Early Years and Families programme at The Whitworth arts gallery
Motoring on with 5G Tech to Step up Safety in Cars
Authors: Knight Helen
Published: July 2023

Partnership to investigate autonomous vehicle tech and aid safety
UAVs to Support Military Air Operations
Authors: Ford Jason
Published: July 2023

Boeing model will protect manned jets
Surgical Glove Simulation
Authors: Wade Andrew
Published: July 2023

HaptX to have hand in assisting VR feedback
Decarbonising Heat Becomes a Hot Topic
Authors: Stirling Will
Published: July 2023

District networks that use locally available waste heat could be key to delivering on the UK's low-carbon energy commitments
Plant-based diet and its effect on coronary artery disease: A narrative review
Authors: Mehta Priyal , Tawfeeq Sawsan , Padte Smitesh , Sunasra Rayyan , Desai Heet , Surani Salim , Kashyap Rahul
Published: July 2023

Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
High expression of autophagy-related gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer
Authors: Yang Shan , Hui Tian-Li , Wang Hao-Qi , Zhang Xi , Mi Yun-Zhe , Cheng Meng , Gao Wei , Geng Cui-Zhi , Li Sai-Nan
Published: July 2023

Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
Delineation of fatty acid metabolism in gastric cancer: Therapeutic implications
Authors: Fu Yu , Wang Bin , Fu Peng , Zhang Lei , Bao Yi , Gao Zhen-Zhen
Published: July 2023

Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
Defining the awareness and attitude of the clinicians through pharmacovigilance in Turkey
Authors: Aydin Ozlem Celik , Aydin Sonay , Guney Hakkı Zafer
Published: July 2023

Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
Contrast-induced ischemic colitis following coronary angiography: A case report
Authors: Qiu Hui , Li Wei-Ping
Published: July 2023

Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
Effect of Nonlocal Elasticity and Phase Lags on the Magneto Thermoelastic Waves in a Composite Cylinder with Hall Current
Authors: Selvamani Rajendran , Mahesh S. , Ebrahimi Farzad
Published: July 2023

In this study, the effect of nonlocal scale value and two phases lags on the free vibration of generalized magneto thermoelastic multilayered LEMV (Linear Elastic Material with Voids)/CFRP (Carbon Fiber Reinforced Polymer) composite cylinder is studied using nonlocal form of linear theory of elasticity. The governing equation of motion is established in longitudinal axis and variable separation model is used to transform the governing equations into a system of differential equations. To investigate vibration analysis from frequency equations, the stress free boundary conditions are adopted at the inner, outer and interface boundaries. The graphical representation of the numerically calculated results for frequency shift, natural frequency, and thermoelastic damping is presented. A special care has been taken to inspect the effect of nonlocal parameter on the aforementioned quantities. The results suggest that the nonlocal scale and the phase lag parameters alter the vibration characteristics of composite cylinders significantly.
Protest Crowds through the Lens of Distributed Cognition
Authors: Wagoner Brady , Awad Sarah H. , Power Séamus A.
Published: July 2023

Abstract: How are ideas transformed into collective causes that can rally and sustain protest crowds? We present a theoretical framework of crowd mobilization through the perspective of distributed cognition. We look at protest crowds as distributed processes that happen across brains, bodies, social interactions, and material-technological resources. This perspective is illustrated by protest crowd dynamics as they are facilitated by social interaction, symbols, narrative forms, and physical and virtual spaces.
The Aesthetics of Protest on Kyiv's Maidan: Reflections on Political Emergence and the Twenty-First-Century Crowd
Authors: Jonsson Stefan
Published: July 2023

Abstract: This essay argues that aesthetic works offer an understanding of the performativity of democratic protests and crowd action. It analyzes a handful of artworks from the Ukrainian Revolution of 2013–2014. The article demonstrates how aesthetic works express what may be termed political emergence: people who have no say in political institutions come together to change the political order. Aesthetic works enable an understanding of political emergence that is mostly unavailable to the social sciences, history, and journalism. The article contends that analysis of crowd action and twenty-first-century collective protest in particular would gain from theoretical and methodological efforts to conjoin social research and aesthetic analysis.
Terrace mode of the Keck telescope primary mirror
Authors: Chanan Gary , Troy Mitchell
Published: July 2023

It has been well-established that for the extremely large segmented-mirror telescopes (ELTs) currently under construction, segment clocking (in-plane rotation) will result in piston errors between neighboring segments. By contrast, the Keck telescopes utilize a fundamentally different edge sensor geometry, which should in principle render them insensitive to this effect. However, we show that as the result of a systematic internal misalignment of the Keck edge sensors, they in fact suffer from clocking-dependent effects that are remarkably similar to those anticipated for segmented-mirror ELTs. The Keck telescopes thus provide a convenient testbed for studying segment clocking and its associated effects. Analysis of Keck phasing data shows that the segment clocking effects are not random, but systematic and lead to a global segment misalignment mode of striking symmetry in which the primary mirror assumes a terraced structure. This terrace mode has been known for some time at Keck but has only recently been understood to be a direct consequence of segment clocking. A quantitative measurement of terrace mode can be used to diagnose and calibrate segment clocking effects at Keck and for future ELTs.