bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Resilience on Happiness at Work of Healthcare Workers: The Moderated Mediating Effect of Work-Life Balance by Social Support at Work
Authors:   Human Engagement Institute, Kim Seoyoon , Lee Jaeeun
Published: October 2023

This study explored the intricate interplay between healthcare workers' resilience and their overall workplace happiness. Additionally, it delved into the mediating role of work-life balance in this relationship and the moderating influence of social support. Data from 275 healthcare worker respondents were collected through an online survey conducted between September 5 and November 30, 2022, and analyzed using SPSS/WIN 27.0 and Process Macro v3.5. The key findings are as follows: First, significant positive correlations existed among workplace happiness, resilience, work-life balance, and social support. Second, Work-life balance played a vital mediating role, significantly enhancing the connection between resilience and workplace happiness. Resilient individuals exhibited improved work-life balance, positively affecting their happiness at work. Third, the mediation was influenced by social support levels; as support decreased, work-life balance's impact on happiness strengthened, while resilience maintained a substantial indirect effect. These findings provide valuable insights into the well-being of healthcare workers and underscore the critical roles played by both resilience and social support in enhancing workplace happiness.
The Importance of Organizational Agility to Improve Performance: Evidence from the Hotel Industry in the Post-Covid-19 Era
Authors: Devie Devie , Kwistianus Hendri , Wellyani Chantika Virginia Putri , Goenadi Go Ruth Natasya Olivia
Published: October 2023

The hospitality industry is one of the industries that has experienced the hardest hit by the COVID-19 pandemic, such as a drastic drop in visitor levels and closed businesses. Despite the importance of organizational agility in the hospitality industry during post-pandemic recovery, there has been rare research on organizational agility in the hotel industry, especially in Indonesia. The research analyzed the effect of organizational agility on organizational performance through competitive advantage and organizational culture as mediating variables in hotels in Indonesia. The research sample was 76 hotels that consist of three-to-five-star hotels in Indonesia. The analysis was conducted using the Structural Equation Modeling (SEM) analysis method through smart Partial Least Square (PLS) software to test the research hypothesis. The results indicate that organizational agility has an important role in increasing organizational performance. Organizational agility has a significant and positive impact on organizational performance in hospitality in Indonesia, with a competitive advantage and organizational culture as mediating variables. The research helps management to understand the importance of having organizational agility in a company to deal with uncertain conditions. The findings also help management not only focus on quality but also on how companies can meet customer needs, create competitiveness, take risks, innovate, and increase profitability to improve organizational performance.
Afgan Kralı Amanullah Han’ın Türkiye Ziyareti (1928)
Authors: ÇELİKBİLEK Abdul Metin
Published: October 2023

Afganistan Türkiye’nin kurtuluş mücadelesinde önemli bir yere sahiptir. Afganistan, Kurtuluş Savaşı sürerken Ankara Hükümeti’ni ilk tanıyan ülkelerin başında olması iki ülke arasındaki ilişkileri olumlu yönde etkimiştir. Afganistan ile Türkiye arasında imzalanan dostluk antlaşmaları, elçiler, teknik ekipler ve heyetlerin gidip gelmesiyle kurulan iyi ilişkiler neticesinde Türk-Afgan münasebetlerinde yeni bir dönem başlamıştır. Bu yeni dönemde Afganistan’ın başında Gazi Mustafa Kemal Paşa’dan ve onun yaptığı büyük devrimlerden çok etkilenen Amanullah Han vardır. Cumhuriyetin ilanından sonra iyi ilişkiler devam etmiştir. Amanullah Han ve eşinin 20 Mayıs 1928’de Türkiye’yi ziyaret etmesi Türk-Afgan münasebetlerinin geliştirilmesi bakımından önemlidir. Ayrıca bu ziyaret, yeni kurulan Türkiye Cumhuriyeti için diğer devletler tarafından tanınması ve kendini dünyaya tanıtması bakımından önemli bir fırsattır. Bu fırsatı iyi değerlendirmek isteyen Gazi Mustafa Kemal Paşa Afganistan kralı Amanullah Han ve eşi kraliçe Süreyyâ’yı büyük bir misafirperverlikle karşılamıştır. Bu sayede ilk kez yabancı bir ülke liderini misafir etmenin heyecanını yaşayan Gazi Mustafa Kemal Paşa ve devlet erkânı Amanullah Han’a Türkiye Cumhuriyeti’nin kazanımlarını tanıtma fırsatı bulmuşlardır. Bu ziyaret Türk-Afgan ilişkilerinde yeni bir dönemin kapılarını açmıştır. Bu çalışmada Afganistan Kralı Amanullah Han’ın Türkiye ziyareti, nasıl karşılandıkları, İstanbul ve Ankara gezileri ele alınmıştır. Ayrıca Amanullah Han’ın Türkiye’de gerçekleşen devrimlerden etkilenmesi ve bu devrimleri Afganistan’da yapmaya çalışmasının doğurduğu sonuçlar üzerinde de durulmuştur.
Ulus-Devletin Anadolu’ya Taşınmasında Demiryolları
Authors: İLYAS Ahmet
Published: October 2023

Osmanlı Devleti’nin demiryolu ile buluşması XIX. yüzyılın ortalarıdır. Öncelikli alan olarak ticari anlamda kullanılan demiryolu hatları, II. Abdülhamit’in askeri ve devlet gücünün yansıtılması amacıyla kullanılmıştır. Birinci Dünya Savaşı’nda ise demiryolları hatları savaşta, askeri teçhizat ve ordunun taşınmasında önemli bir rolü vardır. Geç Osmanlı ve Erken Cumhuriyet Dönemi’nde ise demiryolu bir anlamda ulus-devletin inşa sürecinin başat noktalardan biri haline gelmiştir. Milli Mücadelede hem askeri üstünlük hem de propaganda olarak kullanılan demiryolu, Cumhuriyet idaresinin kurulmasıyla birlikte en çok önem verilen alan olmuştur. Bu çalışma ulus-devlet inşa paradigmasında demiryolunun hangi amaçlarla kullanıldığının ve işlevselliğinin hangi noktada olduğunu yansıtmak amacıyla hazırlanmıştır. Çalışmada Osmanlı’nın demiryolu politikasının temeli ve Cumhuriyet Dönemi’nde dönüşmesine yer verilmiştir. Cumhuriyet Dönemi demiryolu politikasından yola çıkılarak ulus-devlet inşa sürecinde demiryolu ağının ne denli önemli olduğu da örneklerle ifade edilmeye çalışılmıştır. Ayrıca Cumhuriyet mekân ideolojisinin diğer Anadolu şehirlere taşınmasında demiryolu ağının önemine değinilmiştir. Merkez kentlerinin çevresindeki kentlere olan etkisinin demiryolu sayesinde kazanılan ekonomi, nüfus ve sosyo-kültürel kazanımlarda bu çalışmada yer almaktadır.
A study on consumer protection measures in Japan: Focusing on the penalty system
Authors:   European Constitutional Law Association, Park Yongsook
Published: October 2023

Humans are constantly engaged in consumption activities throughout their lives. Regardless of gender, age, residential area, education level, and cultural differences, people participate in economic activities while purchasing various goods and services to satisfy their needs. However, compared to business operators, consumers are often affected by exaggerated advertisements or promotional activities because it is difficult for consumers to obtain accurate and diverse information about products and they are in an inferior position in technical manipulation. In order to reduce the damage caused by this, consumers organize various organizations to seek protection of their rights and interests. In addition, the government stipulates the duties of the state, local governments, business operators, and the roles of consumers and consumer groups, as well as enacting consumer protection laws for the purpose of improving and rationalizing consumer life.
In this paper, four laws, “Act on Prohibition of Private Monopolization and Maintenance of Fair Trade”, “Financial Instruments and Exchange Act”, “Certified Public Accountants Act”, and “Act against Unjustifiable Premiums and Misleading Representations”, for which the penalty system was introduced in Japan, were reviewed.
I would like to summarize Through this, it is intended to discover problems with the penalty system adopted as a consumer protection measure in Japan, and to draw implications for finding ways to recover actual damages for individual consumers.
Growers' irrigation practices, knowledge, trust, and attitudes toward wastewater reuse in Lebanon, Jordan, and Tunisia through a food safety lens
Authors: Faour-Klingbeil Dima , Taybeh Asma’ O. , Mahjoub Olfa , Almashaqbeh Othman , Bou-Mitri Christelle , Samaha Joy J. , Dhaouadi Latifa , Todd Ewen C. D.
Published: October 2023

Maximizing water reuse requires addressing legal and regulatory frameworks, but growers’ understanding of water as a vehicle for pollutants and safe practices is vital in this process. A cross-sectional survey of 85 growers in Lebanon, Jordan, and Tunisia explored these factors. Results showed that 70.6% of growers had limited knowledge about the transmission of pathogens, pesticides, and pharmaceuticals to food crops via treated wastewater (TWW). Additionally, 55% of farmers used TWW for irrigation, while 65.9% believed that it poses health risks to consumers when applied to crops eaten raw. A positive attitude toward TWW was a determining factor for maximizing water reuse applications. However, the limited access and unavailability of treatment plants were the primary reasons for not using TWW (32.9%). More concerning, less than half controlled the quality of irrigation water using microbiological tests (32.9%), chemical tests (37.6%), and turbidity tests (29.4%). Meanwhile, only 40% trusted local authorities’ control of TWW quality and 69.4% had no access to regulatory information. The present study showed the importance of prioritizing growers’ awareness of potential risks and establishing the practice of monitoring of water quality indicators and contaminants. These should be at the forefront of water reuse expansion strategies to mitigate associated risks.
Therapeutic Intervention of Serine Protease Inhibitors against
Hepatitis C Virus
Authors: Kamal Shagufta , Shahzad Asif , Rehman Kanwal , Tariq Komal , Akash Muhammad Sajid Hamid , Imran Muhammad , Assiri Mohammed Ali
Published: October 2023

Hepatitis C virus (HCV) is a globally prevalent and hazardous disorder that is
responsible for inducing several persistent and potentially fatal liver diseases. Current
treatment strategies offer limited efficacy, often accompanied by severe and debilitating
adverse effects. Consequently, there is an urgent and compelling need to develop novel
therapeutic interventions that can provide maximum efficacy in combating HCV while
minimizing the burden of adverse effects on patients. One promising target against HCV
is the NS3-4A serine protease, a complex composed of two HCV-encoded proteins. This
non-covalent heterodimer is crucial in the viral life cycle and has become a primary focus
for therapeutic interventions. Although peginterferon, combined with ribavirin, is
commonly employed for HCV treatment, its efficacy is hampered by significant adverse
effects that can profoundly impact patients' quality of life. In recent years, the development
of direct-acting antiviral agents (DAAs) has emerged as a breakthrough in HCV
therapy. These agents exhibit remarkable potency against the virus and have demonstrated
fewer adverse effects when combined with other DAAs. However, it is important to
note that there is a potential for developing resistance to DAAs due to alterations in the
amino acid position of the NS3-4A protease. This emphasizes the need for ongoing research
to identify strategies that can minimize the emergence of resistance and ensure
long-term effectiveness. While the combination of DAAs holds promise for HCV treatment,
it is crucial to consider the possibility of drug-drug interactions. These interactions
may occur when different DAAs are used concurrently, potentially compromising
their therapeutic efficacy. Therefore, carefully evaluating and monitoring potential drug
interactions are vital to optimize treatment outcomes. In the pursuit of novel therapeutic
interventions for HCV, the field of computational biology and bioinformatics has
emerged as a valuable tool. These advanced technologies and methodologies enable the
development and design of new drugs and therapeutic agents that exhibit maximum efficacy,
reduced risk of resistance, and minimal adverse effects. By leveraging computational
approaches, researchers can efficiently screen and optimize potential candidates, accelerating
the discovery and development of highly effective treatments for HCV, treatments.
Exploring the Theranostic Applications and Prospects of Nanobubbles
Authors: Shah Rahul , Phatak Niraj , Choudhary Ashok , Gadewar Sakshi , Ajazuddin  , Bhattacharya Sankha
Published: October 2023

Anticancer medications as well as additional therapeutic compounds, have poor clinical
effectiveness due to their diverse distribution, non-selectivity for malignant cells, and undesirable
off-target side effects. As a result, ultrasound-based targeted delivery of therapeutic compounds
carried in sophisticated nanocarriers has grown in favor of cancer therapy and control.
Nanobubbles are nanoscale bubbles that exhibit unique physiochemical properties in both their
inner core and outer shell. Manufacturing nanobubbles primarily aims to enhance therapeutic
agents' bioavailability, stability, and targeted delivery. The small size of nanobubbles allows for
their extravasation from blood vessels into surrounding tissues and site-specific release through
ultrasound targeting. Ultrasound technology is widely utilized for therapy due to its speed, safety,
and cost-effectiveness, and micro/nanobubbles, as ultrasound contrast agents, have numerous
potential applications in disease treatment. Thus, combining ultrasound applications with NBs
has recently demonstrated increased localization of anticancer molecules in tumor tissues with
triggered release behavior. Consequently, an effective therapeutic concentration of drugs/genes
is achieved in target tumor tissues with ultimately increased therapeutic efficacy and minimal
side effects on other non-cancerous tissues. This paper provides a brief overview of the production
processes for nanobubbles, along with their key characteristics and potential therapeutic
uses.
A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Authors: Garg Akash , Agrawal Rutvi , Chopra Himansu , Singh Talever , Chaudhary Ramkumar , Tankara Abhishek
Published: October 2023

There are several vaccines available for preventing various bacterial and viral infections,
but still, there are many challenges that require the development of noninvasive, more
efficient, and active vaccines. The advancement in biotechnological tools has provided safer
antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants
of stronger immune response are required. Nanovaccines are effective vaccines when compared
with conventional vaccines as they can induce both Humoral and cell-mediated immune
responses and also provide longer immunogenic memory. The nanocarriers used in vaccines act
as adjuvant. They provide site-specific delivery of antigens and can be used in conjugation with
immunostimulatory molecules for enhancing adjuvant therapy. The nanovaccines avoid degrading
cell pathways and provide effective absorption into blood vessels. The higher potential of
nanovaccines to treat various diseases, such as Acquired Immuno Deficiency Syndrome, Cancer,
Tuberculosis, Malaria and many others, along with their immunological mechanisms and different
types, have been discussed in the review.
A Survey of the Course: ‘How to Successfully Write a Scientific Article’
Authors: Jakovljevic Tamara Sljivancanin , Nikolic Nadja , Martic Jelena
Published: October 2023

Background:

The aim of the present survey was to analyze the knowledge and skills in
medical paper writing of physicians who attended the course “how to write successfully a scientific
paper.”

Methods:

A blind survey was used to analyze participants' knowledge on the topic of the course
“how to write successfully a scientific paper.” Before starting the workshop, participants anonymously
filled out the input questionnaire containing 12 preliminary data questions. The three-hour
course included a lecture on the steps of creating and writing a scientific article with examples. At
the end, all participants anonymously completed the exit questionnaire consisting of 18 questions.
Differences and associations between the collected data were analyzed using appropriate statistical
tests.

Results:

The survey included 22 participants, most of whom were women (16, 72.7%). The participants'
educational level was proportional to their age. 12 of the participants had an intermediate
level, while the others reported higher English proficiency. Half of the participants had never published
an article. A significant difference was observed between English level and being the first
author of an article published in a scientific journal (p = 0.044). Before class, only 13.6% of participants
knew that guidelines are mandatory for making clinical decisions according to evidence-
based medicine. There was a significant positive correlation between sex and current affiliation
(p = 0.038). A negative correlation was observed between sex and article publication (p =
0.037). A positive correlation was observed between English level and current affiliation (p =
0.020). There was a negative correlation observed between previous sources of learning scientific
article writing and having already published an article (p = 0.025). A positive correlation was
found between reading an article and publishing it (p = 0.046). Statistical analysis showed a significant
difference between reading frequency, number of published articles, being the first author,
and knowing the title of a scientific article (p = 0.036, p = 0.027, and p = 0.030, respectively).

Conclusion:

The results of the questionnaires revealed discrepancies in prior research engagement
and understanding of scientific concepts and rules. This survey highlights the importance of the
course “how to successfully write a scientific article” in improving participants' knowledge of scientific
work and the process of creating an article for submission to medical journals.
Fluorescent Materials for Latent Fingerprint Detection
Authors: Rasin Puthiyavalappil , Kumar Vaishnu Suresh , Malappuram Kailas Mahipal , Sreekanth Anandaram
Published: October 2023

This review provides a comprehensive examination of the application of fluorescence
materials for the detection of latent fingerprints in forensic sciences. Traditional methods like powder
dusting, cyanoacrylate fuming, chemical methods, and small particle reagent techniques have shown
limitations due to issues like low contrast, sensitivity, selectivity, and high toxicity. To overcome
these drawbacks, recent focus has shifted towards using fluorescent materials, owing to their unique
optical and chemical properties. This review underscores the importance of latent fingerprint development
employing metal nanoparticles, semiconductor nanoparticles, and organic fluorescence compounds.
These advanced materials not only provide heightened contrast, sensitivity, and selectivity
compared to traditional methods but also manifest diminished toxicity. In essence, the review delivers
a methodical survey of these pioneering techniques.
Impact of Changing Cannabis Laws on Cannabis Use Disorders,
Serious Mental Illness, and Mortality Outcomes in US Youth: A
Narrative Review
Authors: Hammond Christopher J. , Boustead Anne E. , Fristad Mary A. , Pawar Aditya , Steelesmith Danielle L. , Fontanella Cynthia A.
Published: October 2023

Youth cannabis use is a major public health crisis. Cannabis laws carry
significant health implications for American youth. Relaxing of these laws –
through decriminalization, medical and recreational legalization – by a majority of
states in the United States (US) over the past 25 years has dramatically shifted
societal perceptions and adult use. How cannabis policy changes have affected the
population-wide health of US youth and downstream public health implications of
cannabis laws remain topics of significant debate. Cannabis is the most commonly
used federally-illicit drug by US adolescents and the main drug for which US teens
obtain substance use treatment. Adolescent cannabis use is associated with negative
long-term consequences for mental health, risk-taking behaviors, and academic/job
achievement. As of January 2023, 37 states and the District of Columbia (DC) have
enacted medical cannabis laws; of these, 21 states and DC have recreational
cannabis laws. Multiple studies have assessed the association between cannabis
laws and youth cannabis use; results indicate mostly null effects for medical laws
and mixed effects for recreational laws. Little is known about the effects of
cannabis laws on mental health and mortality outcomes for American youth.
Methodological limitations have made the interpretation of this literature difficult.
This article presents a narrative review of current scientific literature investigating
the impact of changing cannabis policies on cannabis and other drug use, mental
health, and mortality outcomes in US youth. Implications are framed within a larger
discussion on national trends in youth drug use, effects of adolescent cannabis
exposure on health outcomes, and research-based policymaking.
Research on Foothold Optimization of the Quadruped Crawling Robot
based on Reinforcement Learning
Authors: Liu Xiulian , Wang Peng , Dong Renquan
Published: October 2023

Background:

Quadruped crawling robots will be faced with stability problems when
walking on a raised slope. The stability of robot is affected by gait planning and selection of its foothold
in this terrain. The slope reaction force on anterior and posterior legs is uneven. The selection
strategy of its foothold should achieve good performance for the stability of the quadruped crawling
robot.

Objective:

Aimed at the uneven problem of slope reaction force on the anterior and posterior legs of
the quadruped crawling robot when walking on the raised slope, a patent method for foothold optimization
using reinforcement learning based on strategy search is proposed.

Methods:

The kinematic model of the quadruped crawling robot is created in D-H coordinate method.
According to the gait timing sequence method, the frame description of the quadruped crawling
robot's gait on the slope is proposed. The fitting polynomial coefficients and fitting curves of all
joints of the leg can be obtained by using the polynomial fitting calculation method. The reinforcement
learning method based on Q-learning algorithm is proposed to find the optimal foothold by
interacting with the slope environment. Comparative simulation and test of other gait and climbing
slope gait, the climbing slope gait with and without the Q-learning algorithm is carried out by
MATLAB platform.

Results:

When the quadruped crawling robot adopts the reinforcement learning method based on Qlearning
algorithm to select foothold, the robot posture curves are compared without optimization
strategy. The result proves that the selection strategy of its foothold is valid.

Conclusion:

The selection strategy of its foothold with reinforcement learning based on Q-learning
algorithm can improve the stability of the quadruped crawling robot on the raised sloped.
Vehicle Trajectory Prediction Considering Multi-feature Independent
Encoding Based on Graph Neural Network
Authors: Su Xiao , Wang Xiaolan , Li Haonan , Xu Xin , Wang Yansong
Published: October 2023

Background:

Today, self-driving cars are already on the roads. However, driving safety
remains a huge challenge. Trajectory prediction of traffic targets is one of the important tasks of an
autonomous driving environment perception system, and its output trajectory can provide necessary
information for decision control and path planning. Although there are many patents and articles
related to trajectory prediction, the accuracy of trajectory prediction still needs to be improved.

Objective:

This paper aimed to propose a novel scheme that considers multi-feature independent
encoding trajectory prediction (MFIE).

Methods:

MFIE is an independently coded trajectory prediction algorithm that consists of a spacetime
interaction module and trajectory prediction module, and considers speed characteristics and
road characteristics. In the spatiotemporal interaction module, an undirected and weightless static
traffic graph is used to represent the interaction between vehicles, and multiple graph convolution
blocks are used to perform data mining on the historical information of target vehicles, capture temporal
features, and process spatial interaction features. In the trajectory prediction module, three long
short-term memory (LSTM) encoders are used to encode the trajectory feature, motion feature, and
road constraint feature independently. The three hidden features are spliced into a tensor, and the
LSTM decoder is used to predict the future trajectory.

Results:

On datasets, such as Apollo and NGSIM, the proposed method has shown lower prediction
error than traditional model-driven and data-driven methods, and predicted more target vehicles at
the same time. It can provide a basis for vehicle path planning on highways and urban roads, and it is
of great significance to the safety of autonomous driving.

Conclusion:

This paper has proposed a multi-feature independent encoders’ trajectory prediction
data-driven algorithm, and the effectiveness of the algorithm is verified with a public dataset. The
trajectory prediction algorithm considering multi-feature independent encoders provides some reference
value for decision planning.
Remote Perimetry in a Virtual Reality Metaverse Environment for Out-of-Hospital Functional Eye Screening Compared Against the Gold Standard Humphrey Visual Fields Perimeter: Proof-of-Concept Pilot Study
Authors: Wong Kang-An , Ang Bryan Chin Hou , Gunasekeran Dinesh Visva , Husain Rahat , Boon Joewee , Vikneson Krishna , Tan Zyna Pei Qi , Tan Gavin Siew Wei , Wong Tien Yin , Agrawal Rupesh
Published: October 2023

Background

The growing global burden of visual impairment necessitates better population eye screening for early detection of eye diseases. However, accessibility to testing is often limited and centralized at in-hospital settings. Furthermore, many eye screening programs were disrupted by the COVID-19 pandemic, presenting an urgent need for out-of-hospital solutions.

Objective

This study investigates the performance of a novel remote perimetry application designed in a virtual reality metaverse environment to enable functional testing in community-based and primary care settings.

Methods

This was a prospective observational study investigating the performance of a novel remote perimetry solution in comparison with the gold standard Humphrey visual field (HVF) perimeter. Subjects received a comprehensive ophthalmologic assessment, HVF perimetry, and remote perimetry testing. The primary outcome measure was the agreement in the classification of overall perimetry result normality by the HVF (Swedish interactive threshold algorithm–fast) and testing with the novel algorithm. Secondary outcome measures included concordance of individual testing points and perimetry topographic maps.

Results

We recruited 10 subjects with an average age of 59.6 (range 28-81) years. Of these, 7 (70%) were male and 3 (30%) were female. The agreement in the classification of overall perimetry results was high (9/10, 90%). The pointwise concordance in the automated classification of individual test points was 83.3% (8.2%; range 75%-100%). In addition, there was good perimetry topographic concordance with the HVF in all subjects.

Conclusions

Remote perimetry in a metaverse environment had good concordance with gold standard perimetry using the HVF and could potentially avail functional eye screening in out-of-hospital settings.
The Impact of Temperature, Humidity, and Sunshine on Internet Search Volumes Related to Psoriasis
Authors: Lane Hakan , Walker Mark
Published: October 2023

We examined internet searches on psoriasis in Germany and found that in weeks with high search volume, mean temperature and humidity were lower and sunshine level was higher compared to weeks with low search volume.
PENGARUH IMPLEMENTASI REKAM MEDIS ELEKTRONIK TERHADAP WAKTU TUNGGU RAWAT JALAN REGULER DI RS HERMINA SOLO
Authors: Fitri Ayu Rachmawati  , Guardian Yoki Sanjaya  , Firman
Published: October 2023

Background: Patient complaints related to the long waiting time for medical record files in the outpatient installation of regular polyclinics at Hermina Solo Hospital increased from January to June 2022, and the average patient waiting time was 3 hours and 30 minutes in the same period.
The Effect of Yijung-tang for Chronic Gastritis: A Systemic Review and Meta-Analysis
Authors: Kim Ye-seul , Lee Yeong-seo , Kim Kyoung-min , Jin Myung-ho
Published: October 2023

Objective: This study assessed the effectiveness of using Yijung-tang to treat chronic gastritis through a systematic review and meta-analysis of randomized controlled trials (RCTs).Methods: The search was conducted using keywords such as “gastritis”, “Lizhong”, “Yijung”, and “Chronic gastritis” on July 31, 2023. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), Traditional chinese medicine symptom score (TSS), gastric hormones, and symptom relief time, using the Review Manager website.Results: A total of 11 RCT studies were selected. The treatment group (Yijung-tang-gagam or Yijung-tang-gagam+ Western medicine) showed significant improvement effects in terms of TER, TSS, serum gastrointestinal hormones (motilin (MTL), gastrin (GAS), and somatostatin (SS)), and symptom relief time compared to the control group (Western medicine). TER-RR : 1.20, 95% CI : 1.11 to 1.30, P≤0.00001, RR : 1.21, 95% CI : 1.14 to 1.28, P≤0.00001; MTL-MD : 35.99, 95% CI : 30.79 to 41.20, P≤0.00001); GAS-MD : 103.33, 95% CI : 97.62 to 109.04, P≤0.00001); SS : MD : -37.19, 95% CI : -41.75 to -32.64, P≤0.00001; symptom relief time (nausea)-MD : -1.96, 95% CI : -2.47 to -1.45, P≤0.00001; symptom relief time (colic)-MD : -1.75, 95% CI : -2.31 to -1.18, P≤0.00001.Conclusion: This study suggests that Yijung-tang is effective against chronic gastritis. However, the number of studies was insufficient, and the diagnosis and evaluation criteria were not standardized. Furthermore, because of the low quality of the included studies, more clinical studies need to be conducted to increase the possibility of clinical use.
Clinical Practice Patterns for Benign Prostatic Hyperplasia: An Online Survey
Authors: Baek Ji-soo , Shin Seon-mi , Cho Chung-sik
Published: October 2023

Objectives: This study investigated Korean medicine doctors’ perspectives on clinical practice patterns in the process of developing Korean medicine clinical practice guidelines for benign prostatic hyperplasia.Methods: A questionnaire was developed for Korean medicine doctors. A total of 323 oriental medicine doctors participated in the survey, which was live for a total of 9 days from September 22, 2022, to September 30, 2022.Results: Regarding awareness of treatments for benign prostatic hyperplasia, 63.8% of respondents showed high awareness of Korean medical treatments. However, items such as diagnostic criteria (17.7%), evaluation methods (17.0%), and Western medical treatments (22.9%) showed low recognition rates. In clinical practice, 76.2% of respondents were found to treat five or fewer patients with benign prostatic hyperplasia per month, and the average treatment period was 1 to 3 months for most at 41.2%. Korean medicine doctors diagnosed benign prostatic hyperplasia based on clinical features. The main interventions used were acupuncture, herbal medicine (prescription medicine), and moxibustion. This study has several limitations because of the low response rate for this survey; therefore, the participants are not representative of all Korean medicine doctors. In addition, because the study was conducted broadly on various topics related to benign prostatic hyperplasia, sufficient quality management was not carried out. Further studies that include a larger sample size and more in-depth studies on benign prostatic hyperplasia are needed.Conclusions: It is necessary to develop appropriate and reasonable Korean medicine clinical practice guidelines for benign prostatic hyperplasia.
Flow conditions for continuous variable measurement-based quantum computing
Authors: Booth Robert I. , Markham Damian
Published: October 2023

In measurement-based quantum computing (MBQC), computation is carried out by a sequence of measurements and corrections on an entangled state. Flow, and related concepts, are powerful techniques for characterising the dependence of the corrections on previous measurement results. We introduce flow-based methods for quantum computation with continuous-variable graph states, which we call CV-flow. These are inspired by, but not equivalent to, the notions of causal flow and g-flow for qubit MBQC. We also show that an MBQC with CV-flow approximates a unitary arbitrarily well in the infinite-squeezing limit, addressing issues of convergence which are unavoidable in the infinite-dimensional setting. In developing our proofs, we provide a method for converting a CV-MBQC computation into a circuit form, analogous to the circuit extraction method of Miyazaki et al, and an efficient algorithm for finding CV-flow when it exists based on the qubit version by Mhalla and Perdrix. Our results and techniques naturally extend to the cases of MBQC for quantum computation with qudits of prime local dimension.
MOBILIZAÇÕES DO “JUNHO INDÍGENA” DE 2021 CONTRA O PL 490 E O MARCO TEMPORAL NO BRASIL
Authors: Mondardo Marcos Leandro , Chaparro Roberto Lopes
Published: October 2023

O ano de 2021 foi histórico para a luta dos povos indígenas no Brasil, seja pelo combate à Covid-19 nos seus territórios, seja na luta para reafirmar seus direitos garantidos constitucionalmente e que estão ameaçados diante do PL 490/2007, que tramita no Congresso Nacional sobre a tese do marco temporal, ainda em processo de votação no Supremo Tribunal Federal (STF). O objetivo deste texto foi, assim, analisar a mobilização realizada pelo Movimento Indígena no Brasil no mês de junho de 2021, denominado de “Junho Indígena”, contra o PL 490/2007 e a tese do marco temporal e os seus impactos na existência dos povos indígenas. Realizou-se uma pesquisa qualitativa para levantar as ações realizadas no período por meio de publicações em redes sociais de organizações e lideranças indígenas, complementadas com informações oriundas de sites, jornais e blogs do movimento indígena e indigenista. Os resultados foram sistematizados e categorizados por meio da análise de conteúdo proposta por Bardin. Os dados revelam que a capacidade de articulação nacional do Movimento Indígena capilarizou ações em todas as cinco regiões do Brasil e performou manifestações variadas em diversos arranjos espaciais, principalmente, bloqueios de tráfegos em rodovias e protestos em ambientes urbanos.
CONSIDERAÇÕES TEÓRICAS SOBRE A MERCADORIA-MORADIA E A PRODUÇÃO DO ESPAÇO URBANO
Authors: Valfré Lorenzo
Published: October 2023

A moradia é, com efeito, o bem imobiliário de maior complexidade das cidades. Não só possui forte dimensão simbólica, material e social, mas também está atrelada fisicamente a uma fração específica e não reprodutível do espaço urbano, o que significa que acessar uma moradia é também acessar, com maior ou menor facilidade, os diversos valores de uso da cidade. Nesse sentido, o objetivo deste artigo é desenvolver considerações teóricas acerca da produção capitalista desse bem, assim como do espaço urbano de modo geral, resgatando para tanto, principalmente, expoentes da sociologia urbana marxista, bem como alguns dos postulados de Marx e Engels - em especial a teoria da renda da terra desse primeiro. Acreditamos que tais considerações possuem forte relevância para a compreensão das particularidades da produção habitacional e do espaço urbano atuais, bem como o potencial de servirem como subsídios para futuros trabalhos inseridos nessa temática, sobre os quais apontamos, ao fim, alguns direcionamentos de atual importância - em especial o que chamamos de "nova produção rentista".
Eficácia da realidade virtual no manejo da dor pediátrica: contribuições da inovação tecnológica em saúde
Authors: Araujo Lucas Vieira , Truppel Thiago Christel , Nitz Darlan , Ogradowski Karin Rosa Persegona
Published: October 2023

Assessing and managing pain in the post-operative period is essential, as acute pain, if left untreated, can alter several organic systems. Virtual reality is a promising low-cost tool for pain relief. This study aimed to determine the effectiveness of virtual reality in the management of mild to moderate acute pain in patients in the immediate postoperative period. This is a randomized clinical study, carried out in a pediatric hospital in Curitiba. Research participants were randomized and allocated into two groups, and shown a relaxing thematic video and virtual reality. Data were subjected to descriptive and inferential statistical analysis. Pain reduction provided by virtual reality is statistically significant and superior when compared to the reduction induced by the relaxing thematic video, and can optimize the hospitalization experience, with attention focused on the patient's experience, mitigating side effects related to the use of opioids.
Hiperdia em uma abordagem interdisciplinar e sua contribuição para o processo de formação do trabalhador de saúde: um relato de experiência
Authors: Dos Santos Silva Fernanda Ayalla , Feltrin de Oliveira Luciane Cristina
Published: October 2023

Este estudo objetiva relatar a vivência frente aos atendimentos de HIPERDIA realizados em uma Unidade de Saúde da Família de forma interdisciplinar e sua contribuição para o processo de formação de trabalhadores de saúde por meio da residência multiprofissional em saúde da família da Universidade Estadual de Feira de Santana (UEFS). Trata-se de um estudo descritivo qualitativo, do tipo relato de experiência, sobre as atividades vivenciadas na Residência Multiprofissional em Saúde da Família (RMSF). Dos 18 pacientes atendidos, observou-se que 58% destes, obtiveram melhorias, bem como um melhor entendimento em relação a sua condição de saúde e os cuidados para além da adesão ao tratamento farmacológico. Assim, atendimentos realizados de forma interdisciplinar aos pacientes do programa, não só contribuiu de forma positiva para a formação do trabalhador em saúde, permitindo a troca de sabres entre profissionais, bem como garantiu a integralidade da atenção aos pacientes. Desta forma, diante da necessidade de que estes pacientes têm quanto a garantia do cuidado em saúde na atenção primária, e da fragilidade que ainda existe nas graduações quanto a atuação interdisciplinar, a Residência Multiprofissional em Saúde da Família, é de grande importância para a formação do trabalhador em saúde, e principalmente para o fortalecimento do SUS.  

Palavras chaves: doenças crônicas por hipertensão e diabetes, sistema único de saúde multiprofissionalidade, interdisciplinaridade.
Participação do sexo feminino nos conselhos editoriais de periódicos científicos da área da farmácia no Brasil
Authors: Lima Tácio de Mendonça , Massa Graziela dos Santos
Published: October 2023

O objetivo do estudo é investigar a distribuição do sexo feminino entre membros do conselho editorial de revistas científicas da área de Farmácia no Brasil. Trata-se de um estudo transversal conduzido no mês de janeiro de 2023. Dados foram extraídos das plataformas Scimago Journal & Country Rank e Qualis Periódicos. Os membros do conselho editorial foram divididos em quatro grupos e determinados com base nas informações disponíveis no endereço eletrônico da revista. O sexo foi classificado de forma binária por meio do nome e da fotografia, das páginas pessoais e institucionais ou do programa Genderize. Um total de 223 periódicos científicos foram identificados nas bases de dados, sendo 10 analisados. Identificamos 359 membros do conselho editorial, sendo apenas 151 (42%) do sexo feminino. Foram identificados 17 editores-chefe, 24 co-editores, 150 editores associados e 168 os demais membros; sendo destes, 9 (52,9%), 12 (50%), 54 (36%) e 76 (45,2%) do sexo feminino, respectivamente. Seis revistas (60%) apresentaram uma maior representação do sexo feminino em relação a toda a equipe do conselho editorial, porém quando estratificado por subgrupo, metade eram mais representados pelo sexo masculino. Foi identificado uma menor participação do sexo feminino entre os membros do conselho editorial de periódicos científicos da área das Ciências Farmacêuticas no Brasil. Estratégias devem ser elaboradas para diminuir essa disparidade e envolver mais o sexo feminino nesses conselhos.
Lesões hepáticas em frangos infectados com escherichia coli: uma revisão sistemática
Authors: Melo Santos Caline , Souza de Oliveira Sampaio Gabriel , De Oliveira Tozetto Klein Sibele , De Matos Mendes da Silva Isabella , Mendes da Silva Ricardo
Published: October 2023

Escherichia coli ocasiona perdas econômicas e danos à sustentabilidade. O presente artigo objetivou realizar uma revisão sistemática acerca das lesões hepáticas em frangos contaminados com E. coli. Foram utilizadas quatro bases de dados eletrônicos (BVS, PubMed, Web of Science e Scopus). Os resultados foram obtidos entre novembro e dezembro de 2021, sem restrição quanto ao período de publicação. Ao final, 29 artigos foram incluídos. Vinte e cinco estudos observaram alterações macroscópicas no fígado associadas à infecção pela bactéria E. coli (86,20%), nestes as mais presentes foram hepatite (60,00%), presença de fibrina (40,00%), alterações no volume ou peso do fígado (36,00%) e mudanças na coloração (16,00%), a maioria destas com alta severidade (36,00%). Vinte e um estudos (72,41%) realizaram análises histológicas. As alterações microscópicas mais frequentes foram infiltrados inflamatórios (66,66%), necrose (47,61%), presença de fibrina (42,85%), hepatite (38,09%) e edema e/ou hemorragia (28,57%), sendo mais recorrente também a classificação como grave (42,85%). Conclui-se que as análises microbiológicas associadas com as histopatológicas são precisas e eficientes ferramentas diagnósticas. Espera-se, portanto, que o atual estudo contribua para o aumento da produtividade, Segurança Alimentar e Nutricional do campo à mesa.
Qualitative fracture analysis of Si-C-N hard coatings: interfacial and triaxiality effect
Authors: Bhattacharyya Arnab S. , Bhattacharyya Kushal
Published: October 2023

The mechanical properties of hard thin films need meticulous and precise
inspection for their efficient applicability. SiCN hard coatings
deposited on silicon substrates underwent Vickers indentation and
fracture analysis was performed with the help of images of fractured
regions under the microscope. The fractured regions were matched with
geometrical patterns and the mechanism of the occurrence of delaminated
and regions subject to brille failure was studied. Finite Element
Analysis (FEA) were carried out to study the elastic-plastic as well as
ductile to brittle transition in the indentation process. The novel
features in the fracture process identified will add to the knowledge in
the field of fractographic studies of hard coatings. The findings shall
be helpful in fracture analysis of components subject to loading used in
heavy-duty equipment as well as MEMS.
The pathogenesis of Acute Exogenous Lipid Pneumonia based on proteomics
Authors: Weng Tingting , Wang Huamin , Xu Zijin , Liang Dong Shi , Huang Ai-Rong , Ye Wanding , Hu Xiaoguang , Xu Zhiwei , Jin Yimei
Published: October 2023

Introduction Acute exogenous lipoid pneumonia (AELP) is a rare
disease. At present, the specific pathogenesis of AELP is unclear, and
there is no safe and effective specific drug. The purpose of this study
is to explore the biological processes, signal pathways and key proteins
involved in AELP through proteomics, bioinformatics and polymerase chain
reaction, so as to deepen the study of the pathogenesis of AELP.
Methods The experimental rats were randomly divided into 2
groups: experiment group (inhaled 0.5 ml/kg of sewing machine oil) and
control group (inhaled 0.5 ml/kg of normal saline). Collect the proteins
in the upper lobe of the right lung of mice for proteomic sequencing to
obtain the expression data, use the differential analysis software
MaxQuant to screen the differentially expressed proteins (DEPs), and use
the bioinformatics analysis method to carry out gene ontology function
(GO), Kyoto Encyclopedia of genes and genomes (KEGG) analysis and
protein-protein interaction (PPI) network construction for DEGs, Eleven
key proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, DEFB4, F3, MK167,
SLC39A4, LIMD1 and GJA1) were detected by Reverse-transcription
polymerase chain reaction (RT-PCR) for validation. Results A
total of 1253 DEPs were obtained after comparing the data of the
experimental group and the control group with the proteome, including
843 up-regulated proteins and 410 down-regulated proteins. Through the
functional analysis of GO and KEGG, it is found that these DEPs mainly
participate in the regulation process of integrin binding, proteoglycan
binding, chemokine receptor binding, receiver regulator binding, and
cytokine activity, and are significantly enriched in proteoglycan
binding and other signal pathways. PPI network construction was carried
out for DEPs to screen out proteins with high correlation, such as
ACTN3, CX3CR1, CCR3, AGT, MYLPF. 11 proteins were verified by
RT-PCR，compared with the control group, 9 proteins (PADI4, IGF2,
SMPDL3B, UHRF1, ANXA8, MK167, SLC39A4, LIMD1 and GJA1) were
significantly up-regulated in the experimental group.
Conclusion Our findings identified that PADI4, IGF2, UHRF1,
DEFB4 and GJA1 proteins may be potential diagnostic biomarker of AELP.
Advancements in Neovascular Ophthalmopathy: Therapeutic Strategies and Future Prospects
Authors: Zhang Miaomiao , Lu Xinyue , Li Ge , Zhang Shixin , Zhang Jingbo , Fu Xiaoge , Sun Fengying
Published: October 2023

Abnormal ocular angiogenesis is a key factor in the development of many
blinding ocular diseases, including wet age-related macular degeneration
(wAMD), diabetic macular oedema (DME), pathologic myopia with choroidal
neovascularization (PM-CNV), and neovascular glaucoma (NVG). The
development of anti-neovascular drugs and ocular drug delivery systems
(DDS) offers more possibilities for the treatment of neovascular eye
diseases. In addition to anti-vascular endothelial growth factor
(anti-VEGF) agents, the discovery of other anti-angiogenic targets, such
as somatostatin, endostatin and pigment epithelium-derived factor
(PEDF), has been a boon to patients with poor anti-VEGF efficacy and led
to a reduction in the adverse effects of long-term VEGF inhibition. Gene
therapy is currently a very promising approach for the treatment of
neovascular ophthalmopathy. The rapid development of gene therapy and
the potential for viral vector-mediated gene delivery to achieve
sustained expression of anti-vascular substances at the lesion site will
mitigate the risks associated with frequent intraocular injections for
patients. This review provides an overview of several neovascular
ophthalmopathies, discusses the use of anti-vascular therapeutic agents
and common DDS, and summarizes treatment strategies and future
perspectives for neovascular ophthalmopathy.