bluuebunny/crossref_metadata_2025 huggingface dataset:
Dose-Specific Intratumoral GM-CSF Modulates Breast Tumor Oxygenation and Antitumor Immunity
Authors: Mihalik Nicole E , Steinberger Kayla J , Stevens Alyson M , Bobko Andrey A , Hoblitzell E Hannah , Tseytlin Oxana , Akhter Halima , Dziadowicz Sebastian A , Wang Lei , O’Connell Ryan C , Monaghan Kelly L , Hu Gangqing , Mo Xiaokui , Khramtsov Valery V , Tseytlin Mark , Driesschaert Benoit , Wan Edwin C K , Eubank Timothy D
Published: September 2023

GM-CSF has been employed as an adjuvant to cancer immunotherapy with mixed results based on dosage. We previously showed that GM-CSF regulated tumor angiogenesis by stimulating soluble vascular endothelial growth factor (VEGF) receptor-1 from monocytes/macrophages in a dose-dependent manner that neutralized free VEGF, and intratumoral injections of high-dose GM-CSF ablated blood vessels and worsened hypoxia in orthotopic polyoma middle T Ag (PyMT) triple-negative breast cancer (TNBC). In this study, we assessed both immunoregulatory and oxygen-regulatory components of low-dose versus high-dose GM-CSF to compare effects on tumor oxygen, vasculature, and antitumor immunity. We performed intratumoral injections of low-dose GM-CSF or saline controls for 3 wk in FVB/N PyMT TNBC. Low-dose GM-CSF uniquely reduced tumor hypoxia and normalized tumor vasculature by increasing NG2+ pericyte coverage on CD31+ endothelial cells. Priming of “cold,” anti-PD1–resistant PyMT tumors with low-dose GM-CSF (hypoxia reduced) sensitized tumors to anti-PD1, whereas high-dose GM-CSF (hypoxia exacerbated) did not. Low-dose GM-CSF reduced hypoxic and inflammatory tumor-associated macrophage (TAM) transcriptional profiles; however, no phenotypic modulation of TAMs or tumor-infiltrating lymphocytes were observed by flow cytometry. In contrast, high-dose GM-CSF priming increased infiltration of TAMs lacking the MHC class IIhi phenotype or immunostimulatory marker expression, indicating an immunosuppressive phenotype under hypoxia. However, in anti-PD1 (programmed cell death 1)–susceptible BALB/c 4T1 tumors (considered hot versus PyMT), high-dose GM-CSF increased MHC class IIhi TAMs and immunostimulatory molecules, suggesting disparate effects of high-dose GM-CSF across PyMT versus 4T1 TNBC models. Our data demonstrate a (to our knowledge) novel role for low-dose GM-CSF in reducing tumor hypoxia for synergy with anti-PD1 and highlight why dosage and setting of GM-CSF in cancer immunotherapy regimens require careful consideration.
Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients
Authors: Rosenberg-Hasson Yael , Holmes Tyson H , Diray-Arce Joann , Chen Jing , Kellogg Ryan , Snyder Michael , Becker Patrice M , Ozonoff Al , Rouphael Nadine , Reed Elaine F ,   IMPACC Network, Maecker Holden T
Published: September 2023

The clinical trajectory of COVID-19 may be influenced by previous responses to heterologous viruses. We examined the relationship of Abs against different viruses to clinical trajectory groups from the National Institutes of Health IMPACC (Immunophenotyping Assessment in a COVID-19 Cohort) study of hospitalized COVID-19 patients. Whereas initial Ab titers to SARS-CoV-2 tended to be higher with increasing severity (excluding fatal disease), those to seasonal coronaviruses trended in the opposite direction. Initial Ab titers to influenza and parainfluenza viruses also tended to be lower with increasing severity. However, no significant relationship was observed for Abs to other viruses, including measles, CMV, EBV, and respiratory syncytial virus. We hypothesize that some individuals may produce lower or less durable Ab responses to respiratory viruses generally (reflected in lower baseline titers in our study), and that this may carry over into poorer outcomes for COVID-19 (despite high initial SARS-CoV-2 titers). We further looked at longitudinal changes in Ab responses to heterologous viruses, but found little change during the course of acute COVID-19 infection. We saw significant trends with age for Ab levels to many of these viruses, but no difference in longitudinal SARS-CoV-2 titers for those with high versus low seasonal coronavirus titers. We detected no difference in longitudinal SARS-CoV-2 titers for CMV seropositive versus seronegative patients, although there was an overrepresentation of CMV seropositives among the IMPACC cohort, compared with expected frequencies in the United States population. Our results both reinforce findings from other studies and suggest (to our knowledge) new relationships between the response to SARS-CoV-2 and Abs to heterologous viruses.
Are elevated mitochondrial DNA fragments in prostatic inflammation a potential biomarker for prostate cancer?
Authors: Aferin Ugur , Bahtiyar Nurten , Onaran Ilhan , Ozkara Hamdi
Published: September 2023

Background: We sought to determine whether two soluble forms with different size of mtDNA are linked to prostatic inflammation, and whether they discriminate prostate cancer (PCa) from inflammatory prostatic conditions. Methods: Histopathologically diagnosed prostatitis, PCa and benign prostatic hyperplasia patients (n = 93) were enrolled in this study and they were categorized as with and without prostate inflammation. Quantitative RT-PCR was used to analyze the levels of 79-bp and 230-bp fragments in urine and blood samples collected following prostate massage. Results: The urine mtDNA-79 and mtDNA-230 were significantly increased in patients with prostate inflammation compared with those in without inflammation. Here, 79-bp fragment of apoptotic origin was significantly higher level than 230-bp fragment of necrotic origin. Although mtDNA-79 copy number in serum samples was also increased in patients with prostate inflammation, mtDNA-230 was similar in the two groups. Furthermore, mtDNA-79 and mtDNA-230 copy numbers in postprostate massage urine were higher (about 16-fold and 22-fold, respectively) than those from serum samples. ROC analysis showed that, although post-prostate massage urine have relatively higher performance than blood, ability to discriminate cases of both fragments was not better than that of serum total PSA. Conclusions: Our results demonstrate that shorter cf-mtDNA fragment size in particular, increase in the presence of prostate inflammation in post-prostatic massage urine but both fragments could never improve serum total PSA performance.
Omne aevum tribus explicare annis: Predlog za celovito obravnavo antične kulture in civilizacije
Authors: Kvartič Gašper
Published: September 2023

Če želimo učencem in dijakom ponuditi celotno sliko rimske antike, nam na področju kulture in civilizacije v obstoječih učnih načrtih nekaj manjka. Bistveni elementi so nedvomno prisotni; toda če želimo doseči tudi globino, ki jo nudi klasična tradicija, moramo nejezikovne vsebine dopolniti in jih v roku treh oziroma štirih let ponuditi na smiseln, organiziran način. V članku ponujena dopolnitev učnih načrtov je namenjena temu, da bi se pouk kulturno-civilizacijskih vsebin po Sloveniji poenotil (tako kot so jezikovne vsebine že zdaj). Seveda pa moramo vedno imeti v mislih, da se pogovarjamo o eni sami stvari – klasični rimski antiki – ter tematskih sklopov ne na silo ločevati, temveč se jih truditi integrirati in povezovati v eno samo koherentno celoto, ki bo učitelju in učencu v veselje.
Pouk latinščine kot priložnost za kulturno in jezikovno ozaveščanje
Authors: Osredkar Olga
Published: September 2023

Gimnazijska leta so za mladega človeka priložnost, da raste in se razvija na vseh področjih, tako telesno in umsko kot čustveno in duhovno. Izobraževanje ne pomeni le nabiranja splošnega znanja ali podlage za študij. Pouk klasičnih jezikov daje mladim izobraževalno širino in je priložnost za jezikovno ozaveščanje. Latinščina je jezik, ki povezuje in ne ločuje, jezik, ki pripada vsakomur v enaki meri in je od vsakogar enako oddaljen. Ni ne moj ne tvoj, ni od nikogar in je od vseh.
Katja Pavlič Škerjanc septuagenaria
Authors: Movrin David , Ahačič Kozma , Batagelj Katarina , Dekleva Goran , Grošelj Nada , Gruden Nina , Homar Nataša , Inkret Andreja , Jevtić Iva , Komelj Miklavž , Kovač Petersson Vanja , Krošelj Košec Lucija , Lihtenvalner Maja , Narat Boštjan , Okorn Niko , Pobežin Gregor , Ponikvar Primož , Sašek Simona , Senegačnik Brane , Uhlik Mladen , Vidmar Rukavina Nadja , Weiss Sonja , Žmavc Janja , Novak Aleš
Published: September 2023

Ad multos annos
Eksistenca literarnih likov in neverbalna motivacija v Sofoklovi tragediji ter dramska klima
Authors: Senegačnik Brane , Valijev Sergej
Published: September 2023

Pričujoči članek obravnava vpliv dramske klime, v kateri se prepletajo zunanje in notranje okoliščine dramskega dogajanja, na odločitve, sodbe in ravnanja dramskih likov. To ponazarjava s primeroma iz Antigone in Trahink. V vzdušju povojnih Teb Ismena omahuje med strahom pred kaznijo in strahom pred božanskim srdom zaradi nepokopa Polinejka. Prav tako lahko vpliv dramske klime opazimo v Kreontovi spremembi odločitve glede Ismenine obsodbe na smrt. Posebno pozornost v članku dobi tudi zahtevno vprašanje atribucije verzov v Antigoni 572, 574 in 576, ki pomembno vpliva na razume­vanje psihologije junakov. Druga obravnavana junakinja, Dejanejra, strahoma pričakuje prerokovano odločitev Heraklove usode v Tra­hini, na robu civilizacije. S spoznanjem resnice o Ioli se Dejanejrina psihološka napetost zaostri do skrajnosti in po premisleku, ki zori v njej v zaodrski tišini med prvim in drugim dejanjem, se odloči za usodno dejanje.
Linguam Latinam didicisse: Cilji in izzivi sodobnega pouka latinščine
Authors: Inkret Andreja
Published: September 2023

Kaj učimo, ko v sodobni slovenski gimnaziji učimo latinsko? S kakšnimi cilji vstopamo v razrede, kaj pričakujemo, da bodo naši dijaki znali? Navedena vprašanja so le na videz preprosta. V najbolj pragmatičnem smislu nanje odgovarja veljavni učni načrt za latinščino, ki niza cilje pouka in s tem pričakovane zmožnosti dijakov. V tem prispevku skušam slednje osvetliti z zornega kota prakse in sicer z vpogledom v slovensko državno tekmovanje v znanju latinščine, namenjeno di­jakom tretjega letnika gimnazije. Ob tem izhajam iz predpostavke, da je tekmovalne naloge moč vsaj do določene mere imeti za »praktično« dopolnilo učnemu načrtu, za dovolj reprezentativne odgovore na vpra­šanje, kaj si pod začrtanimi cilji predstavljamo povsem pragmatično, in tako tudi za ilustrativen prikaz naših skupnih pričakovanj o tem, katere kompetence naj bi dijaki po skoraj treh letih gimnazijskega učenja imeli. Tekmovalne naloge, deloma pa tudi dileme, ki jih pred ocenjevalce postavlja točkovanje odgovorov, mi obenem služijo kot osnova za razmislek o tem, kje ležijo prednosti in didaktični izzivi sodobnega pouka latinščine.
Sistem Kendali Robot Pemadam Api Pintar menggunakan Metode Fuzzy Logic Tsukamoto
Authors: Deolika Agatha , Setiawan Erik
Published: September 2023

Kebutuhan robot pada era sekarang ini sangat dibutuhkan karena banyak sekali pekerjaan yang beresiko tinggi. Robot pemadan api salah satunya, sangat penting sekali karena memadamkan api adalah pekerjaan beresiko dan butuh ketelitian. Suatu robot pemadam api untuk menemukan lokasi titik api harus memiliki pergerakan yang efisien seperti kecepatan robot mencapai titik api. Pergerakan robot bergantung pada posisinya pada arena atau jalan, sehingga sering terjadi gerakan sia-sia yang berakibat menabrak dinding atau halangan. Pada penelitian ini dilakukan penerapan metode Tsukamoto untuk kontrol kecepatan robot berdasarkan sensor-sensor. Setelah dilakukan penelitian dan penerapan metode Tsukamoto, robot dapat bergerak efisien dengan akurasi 90%.
Literatura argentina y extranjería: variaciones Piglia sobre Hudson
Authors: Bracamonte Jorge
Published: September 2023

Los vínculos construidos por la poética de Ricardo Piglia con la figura, trayectoria y obra de William Hudson recorren distintas etapas, diferentes variaciones. Respecto a Hudson, resulta decisiva para Piglia la valoración que Ezequiel Martínez Estrada hace de la obra y trayectoria de Hudson. Ello se detecta desde los años de formación del joven escritor Piglia, durante la década de 1950. Luego, durante las décadas de 1960 y 1970, el gradual y radical posicionamiento teórico y político-literario de Piglia lo llevará a considerar en algún momento la figura de Hudson como la de un extranjero de notable obra, pero en definitiva exótico y que permanece en una mirada colonizada respecto a la cultura argentina. Finalmente, Piglia revaloriza al Hudson lector y escritor, clave para las literaturas y culturas argentina y anglosajona, quien también es un crítico radical del capitalismo. Este ensayo interroga los matices de esos diferentes momentos.
¿Región Hudson?
Authors: Arancet Ruda María Amelia
Published: September 2023

En el presente artículo postulamos la existencia de lo que denominamos Región Hudson. Para ello elegimos el nombre de región (Molina y Varela; Heredia), pero enriquecemos el concepto con lo que regionalidad (Arendt) y biorregión (McGinnis et alii) tienen para aportar. A su vez, nuestra mirada sobre esta región es eco, de acuerdo con algunos de los teóricos del amplio espectro de la ecocrítica, especialmente Mathews, Naess y Fukuoka. Esta elección parece el devenir natural para considerar un autor como William Henry Hudson, preocupado por el conservacionismo natural desde el siglo XIX. Así, damos notas de lo que consideraremos región; tomaremos para la región Hudson los elementos cognitivos indicados para ello por Mariana N. Saua y finalmente veremos cómo se concreta esta región. No es una propuesta que parte de lo abstracto, sino de constatar que en la zona del Río de la Plata son las muchas producciones que, de distintas maneras, se ubican en la estela de Hudson en cuanto a: el amor por la naturaleza, su percepción como vivencia íntima y, luego, la puesta en discurso. Aquí, además de considerar su Allá lejos y hace tiempo (1918), añadimos las obras Allá en lo verde Hudson (2012), de Arnaldo Calveyra; Libro de horas (2015), de Laura Forchetti; y Ornitología para principiantes (2018), de Daniel Dellazuana.
Tabaconas. Un proceso histórico, turístico y cultural desde la perspectiva de la ceja de selva
Authors: Carrasco Huaman Dilser Ivan , Fernández Alvarado Julio César , Cervera Gomez Rovin Liskens , Moreto Guerrero Wesley Nilver
Published: September 2023

El libro es una visión integral de todo el proceso de cambios que ha experimentado el distrito de Tabaconas, que está dentro de la ceja de selva del Perú, el mismo que destaca por la geografía propia de zona de Paramó, con el Santuario Nacional Tabaconas Namballe, refugio natural del oso de anteojos (Tremarctos ornatus) y del Tapir de altura (Tapirus pinchaque). La relación entre la historia y la tradición oral del distrito, ayuda a comprender parte de esa historia poco conocida, pero que existe en el inconsciente colectivo de su población trasmitido de padres a hijos. La actividad turística propia de la zona que es de carácter vivencial, natural y cultural, que tiene recursos turísticos que amerita conocer y desarrollar para incentivar el turismo sin chimeneas, cuidando el medio ambiente. Se destaca los antecedentes de la zona en estudio, el tema de la cultura asentada en esta parte de la ceja de selva, la prospección realizada en colaboración con la población del distrito, permitiendo la identificación de los petroglifos de Manchara o Piedra Bola, el cerro Coyona, el caserío Puente Piedra, el coliseo de piedra del Huascaray y el cerro Shipa o Cueva del Higuerón. Al final, se presenta una propuesta interpretativa y cronológica acerca del distrito de Tabaconas destacando que la zona de ceja de selva, tiene una presencia desde la época de pescadores, recolectores nómades, el periodo Formativo hasta la presencia Inca.
Существование классических решений для класса уравнений типа Хохлова - Заболоцкой - Кузнецова
Authors: Bouakaz A. , Bouhmila F. , Georgiev S.G. , Kheloufi A. , Khoufache S.
Published: September 2023

In medical sciences, during medical exploration and diagnosis of tissues or in medical imaging, we often use mathematical models to answer questions related to these examinations. Among these models, the nonlinear partial differential equation of the Khokhlov--Zabolotskaya--Kuznetsov type (abbreviated as the KZK equation) is of proven interest in ultrasound acoustics problems. This mathematical model describes the nonlinear propagation of a sound pulse of finite amplitude in a thermo-viscous medium. The equation is obtained by combining the conservation of mass equation, the conservation of momentum equation and the equations of state. It should be noted that for this equation little mathematical analysis is reserved. This equation takes into account three combined effects: the diffraction of the wave, the absorption of energy and the nonlinearity of the medium in which the wave propagates. KZK-type equation introduced in this paper is a modified version of the KZK model known in acoustics. We study a class of~the~Khokhlov--Zabolotskaya--Kuznetsov type equations for the existence of global classical solutions. We~give conditions under which the considered equations have at least one and at least two classical solutions. To prove our main results, we propose a new approach based on recent theoretical results.
Интегрирование модифицированного уравнения Кортевега - де Фриза с зависящими от времени коэффициентами и с самосогласованным источником
Authors: Собиров Ш.К. , Хоитметов У.А.
Published: September 2023

В данной работе рассматривается задача Коши для модифицированного уравнения Кортевега - де Фриза с зависящими от времени коэффициентами и самосогласованным источником в классе быстроубывающих функций. Для решения поставленной задачи используется метод обратной задачи теории рассеяния. Найдены пары Лакса, что позволит применить метод обратной задачи рассеяния для решения поставленной задачи Коши. Отметим, что в рассматриваемом случае оператор Дирака не является самосопряженным, поэтому собственные значения могут быть кратными. Найдены уравнения динамики изменения во времени данных рассеяния несамосопряженного оператора Дирака с потенциалом, являющимся решением модифицированного уравнения Кортевега - де Фриза с переменными коэффициентами, зависящими от времени и с самосогласованным источником в классе быстроубывающих функций. Рассмотрен особый случай модифицированного уравнения Кортевега - де Фриза с переменными коэффициентами, зависящими от времени, и самосогласованным источником, а именно нагруженное модифицированное уравнение Кортевега - де Фриза с самосогласованным источником. Найдены уравнения динамики изменения во времени данных рассеяния несамосопряженного оператора оператора Дирака с потенциалом, являющимся решением нагруженного модифицированного уравнения Кортевега - де Фриза с переменными коэффициентами в классе быстроубывающих функций. Приведены примеры, иллюстрирующие применение полученных результатов.
ON LITERARY AND FOLKLORE TRANSFORMATION IN THE NOVEL “A HUNDRED AND FIRST PASS” BY I. MASHBASH
Authors: ТХАГАЗИТОВ Ю.М. , ХАВЖОКОВА Л.Б.
Published: September 2023

Авторами статьи предлагается концепция осмысления/переосмысления «малоформатного» романа «Сто первый перевал» Исхака Машбаша как редкого и оригинального явления в северокавказской литературе. Актуальность заявленной проблемы определяется диалектикой соотношения «своего» и «чужого» (национального и общечеловеческого), уровней взаимообусловленности этнически-циклического и «эсхатологического» типов сознания, актуализированных противоречиво глобализирующимся миром. Научная новизна исследования состоит в том, что роман И. Машбаша исследуется в новаторском аспекте, с акцентированием внимания на отчетливо проявляющейся в нем литературно-фольклорной трансформации. Отмечается заслуга двух ключевых писателей – Алима Кешокова и Исхака Машбаша, сыгравших заметную роль в становлении и эволюции национальной романистики: выявляются типологические схождения и различия их романов «Сломанная подкова» и «Сто первый перевал». Главным объектом исследовательского внимания является второй из указанных романов. В статье применен ряд научных методов, в числе главных – анализ, описание, сравнительно-исторический и герменевтический методы. Полученные результаты могут быть использованы при изучении истории адыгской литературы, и в более обширном плане – литературы народов Северного Кавказа и Российской Федерации, а также при составлении спецкурсов и написании квалификационных и другого рода исследовательских работ.

The authors of the article propose the concept of understanding/rethinking the "small-format" novel "A hundred and first pass" by Iskhak Mashbash as a rare and original phenomenon in the North Caucasian literature. The urgency of the stated problem is determined by the dialectic of the correlation of "one's own" and "alien" (national and universal), the levels of interdependence of ethnic-cyclic and "eschatological" types of consciousness, actualized by the contradictory globalizing world. The scientific novelty of the study lies in the fact that the novel by I. Mashbash is studied in an innovative aspect, with an emphasis on the literary and folklore transformation that is clearly manifested in it. The merit of two key writers – Alim Keshokov and Iskhak Mashbash, who played a significant role in the formation and evolution of national romance is noted: typological similarities and differences between their novels "The Broken Horseshoe" and "A hundred and first pass" are revealed. The main object of research attention is the second of these novels. The article uses a number of scientific methods, among the main ones are analysis, description, comparative historical and hermeneutical methods. The results obtained can be used in the study of the history of the Adyghe literature, and in a broader sense – the literature of the peoples of the North Caucasus and the Russian Federation, as well as in the preparation of special courses and writing qualifying and other kinds of research papers.
Inversion of a Convolution Operator Associated with Spherical Means
Authors: Волчкова Н.П. , Волчков В.В.
Published: September 2023

Очевидным свойством произвольной ненулевой гладкой антипериодической функции является отсутствие соответствующего периода у ее производной. Другими словами, если $r$ - фиксированное положительное число и на вещественной оси $f(x+r)+f(x-r)=0$ и $f'(x+r)-f'(x-r)=0$, то $f=0$. Этот факт допускает нетривиальные обобщения на многомерные пространства. Одним из общих методов для таких обобщений является следующая теорема Брауна - Шрейбера - Тейлора о спектральном анализе: любое ненулевое подпространство $\mathcal{U}$ в $C(\mathbb{R}^n)$, инвариантное относительно всех движений $\mathbb{R}^n$, содержит радиальную функцию вида $(\lambda|x|)^{1-\frac{n}{2}}J_{\frac{n}{2}-1}(\lambda|x|)$, где $\lambda$ - некоторое комплексное число, $J_\nu$ -- функция Бесселя первого рода порядка $\nu$. В частности, если функция $f\in C^1(\mathbb{R}^n)$ и ее нормальная производная имеют нулевые интегралы по всем сферам фиксированного радиуса $r$ в $\mathbb{R}^n$, то $f=0$. В терминах сверток это означает инъективность оператора $\mathcal{P}f =(f\ast \Delta \chi_r, f\ast \sigma_r)$, $f\in C(\mathbb{R}^n)$, где $\Delta$ - оператор Лапласа, $\chi_{r}$ - индикатор шара $B_r=\{x\in\mathbb{R}^n: |x|<r\}$, $\sigma_{r}$ - поверхностная дельта-функция, сосредоточенная на сфере $S_r= \{x\in\mathbb{R}^n: |x|=r\}$. В данной работе изучается задача об обращении оператора $\mathcal{P}$ на классе распределений. Получена новая формула восстановления распределения $f\in \mathcal{D}'(\mathbb{R}^n)$ по известным сверткам $f\ast \Delta \chi_r$ и $f\ast \sigma_r$. В работе используются методы гармонического анализа, а также теории целых и специальных функций. Ключевым шагом в доказательстве основного результата является разложение дельта-функции Дирака по системе радиальных распределений с носителями в $\overline{B}_r$, биортогональной к некоторой системе сферических функций. Подобный подход можно использовать для обращения других операторов свертки с радиальными распределениями из $\mathcal{E}'(\mathbb{R}^n)$.
Pengaruh Motivasi dan Lingkungan Masyarakat Terhadap Keputusan Bekerja di Luar Negeri
Authors: Andiyatul Lu’lu  , Muhammad Syaifulloh  , Mukson Mukson , Afridah Nur
Published: September 2023

Tujuan pada penelitian ini untuk mengetahui pengaruh motivasi dan lingkungan masyarakat terhadap keputusan bekerja di luar negeri desa songgom lor. Metode penelitian yang digunakan adalah metode survey dengan pendekatan kuantitatif. Populasi dalam penelitian ini dilakukan terhadap warga songgom sedangkan sampel sebanyak 30 reponden yang dibagi secara acak atau random. Metode penelitian yang digunakan yaitu Uji hipotesis menggunakan product moment, uji koefisien determinasi dan uji reliabilitas alpha. Teknik pengumpulan data dilakukan dengan menggunakan angket atau kuisoner pernyataan-pernyataan mengenai motivasi dan lingkungan masyarakat terhadap keputusan bekerja di luar negeri yang dibagikan kepada para perempuan didesa songgom. Pengujian hipotesis menggunakan analisis regresi linear berganda melalui (uji F) dan (uji t) dengan maksud untuk mengetahui pengaruh variabel independent terhadap variabel dependent pada tingkat signifikansi α = 0,05. Hasil penelitian menunjukkan bahwa hipotesis alternatif (Ha) diterima dan hipotesis nol (Ho) ditolak yang berarti terdapat pengaruh antara motivasi dan lingkungan masyarakat terhadap keputusan bekerja di luar negeri Songgom lor.
Pengaruh Gaya Kepemimpinan dan Motivasi Kerja Terhadap Kinerja Karyawan Pada PT. Daehan Global
Authors: Dumadi Dumadi , Ayu Ainunnisa  , Khojin Nur , Harini Dwi
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan dan motivasi kerja terhadap kinerja karyawan PT.Daehan-Global-Brebes.Data diperoleh dari penyebaran kuesioner kepada karyawan PT.Daehan Global di departemen cutting berjumlah 40 orang. Teknik analisis data yang digunakan dalam penelitian ini yaitu uji asumsi klasik. Analisis data menggunakan regresi linier berganda untuk memperoleh gambaran menyeluruh mengenai hubungan antara variabel. Hasil penelitian menunjukkan bahwa gaya kepemimpinan tidak berpengaruh terhadap kinerja karyawan dan motivasi kerja berpengaruh positif  signifikan terhadap kinerja karyawan PT.Daehan Global. Berdasarkan analisis data persamaan regresi linier di peroleh sebagai berikut Y = 18.859 - 0,047X1 + 0,390X2. Pengujian Hipotesis menggunakan Uji t bahwa variabel gaya kepemimpinan tidak berpengaruh terhadap kinerja karyawan dan variabel motivasi kerja berpengaruh positif terhadap kinerja karyawan.Hasil penelitian secara simultan dengan menggunakan uji F,menunjukan bahwa dua variabel bebas ada yang tidak berpengaruh signifikan terhadap kinerja karyawan. Nilai R Square sebesar 0,203 yang dapat di artikan bahwa variabel gaya kepemimpinan (X1) dan motivasi kerja (X2) terhadap kinerja karyawan (Y) sebesar 20,3% sedangkan sisanya 70,7% di pengaruhi oleh variabel
Analisis Kendala Pengembangan Pertumbuhan Produksi Perusahaan Semen dan Struktur Keuangan terhadap Kinerja SCM di Periode Pandemi
Authors: Fuad Syamlan Adiba , Soelistya Djoko , Ilham Rachmad
Published: September 2023

The success of companies in today's global competition is strongly influenced by their ability to utilize resources. In our country, which has an open market system with government linkages through the customs and excise department of state-owned enterprises, development is very rapid. Management teams in the project business are faced with the challenge of making choices and decisions that support desired goals, even though change often complicates their task. Researchers make earlystage observations to obtain data and manage it to show the progress of achievement in each buyer's transaction during a certain period. In managing a business, there are two competing theories, namely maximizing producer surplus and maximizing stakeholder surplus. Both of these theories can be alternatives that compete or complement each other. It is important for companies to understand and implement expansion, which is the expansion of the company's territory by occupying other areas either partially or wholly. This aims to achieve efficiency, gain higher profits, and remain competitive. This study uses a combination of qualitative and quantitative methods, with a focus on the effect of changes in work pattern systems on improving company performance and profits. The results of the study show that changes in work pattern systems have a positive impact on companies, increasing activities and the range of products offered. These changes also affected the performance of all employees in the marketing division and the company as a whole. In order to reach a conclusion, this study confirms that the change in the work pattern system is more profitable than the previous pattern system, because it has brought development to the company with a positive influence on performance and profits, as well as affecting the overall company turnover.
Korelasi Atribut Produk Dan Performa Karyawan Terhadap Kepuasan Konsumen Fazza T&T
Authors: Sudirman Rendy
Published: September 2023

This study aims to determine the impact that product attributes and employee performance have on customer satisfaction in companies in the tourism sector that are returning after the COVID-19 pandemic. The research method uses associative quantitative methods with data collection methods using questionnaires to Fazza Tour and Travel consumers, with as many as 300 respondents through accidental sampling techniques during May–July 2023. Meanwhile, the hypothesis analysis uses Spearman's rank correlation analysis. The results showed that product attributes had a positive and significant effect on customer satisfaction as evidenced by a correlation value of 0.791 and a significance value below 5%, which meant that the correlation was in the strong category, and employee performance had a positive and significant effect on customer satisfaction as evidenced by a correlation value of 0.672 and a significance value below 5%, which meant that the correlation was in the strong category.
PENGEMBANGAN KEDAI BESTE COFFEE
Authors: Kurniawan Akh Khotib , Qintari Yudith Vitarani Safira
Published: September 2023

Pengembangan kedai kopi ‘’ BESTE COFFEE ‘’ Program Studi Ilmu dan Teknologi Pangan Fakultas Sains dan Teknologi di dalam lingkungan kampus sebagai ruang untuk baik musyawarah, berdiskusi maupun mengerjakan tugas baik dosen maupun mahasiswa di lingkungan kampus sambil menikmati kopi, tujuan dari pengembangan ini adalah mengetahui  strategi yang akan dilakukan dalam pengembangan kedai ‘’BESTE COFFE’’ dilingkungan kampus, menggunakan metode analisis diantaranya pengembangan produk  baru dan menggunakan analisis SWOT Strenght ( Kekuatan ), Weaknes ( Kelemahan), Opportunity (Peluang) dan Treast (Ancaman). Hasil dari pengembangan kedai ‘’BESTE COFFE’’ yaitu adanya produk baru , mengetahui SWOT dari pengembangan kedai. Perlunya sebuah strategi dalam mengembangkan sebuah usaha kopi agar dapat diterima di dalam lingkungan kampus.
PENGARUH TEMPERATUR PEMANASAN TERHADAP SENSORI WARNA PRODUK SARI BUAH LEMON
Authors: Nurlatifah Rois , Unzilatirrizqi Yan El Rizal , Fera Melly
Published: September 2023

Kualitas produk sari buah tergantung dari kesegaran dan kandungan zat. Warna merupakan salah satu indikator untuk menentukan kualitas produk. Penelitian ini bertujuan untuk membandingkan kualitas sensori pada warna yang disebabkan oleh pengaruh temperatur pemanasan sari buah lemon. Metode pada penelitian ini dilakukan secara eksperimental dengan perlakuan suhu dengan pengamatan sensori warna. Hasil menunjukkan bahwa semua perlakuan memiliki warna yang sama yaitu kuning pucat. Perlakuan pemanasan pada 00C pada suhu ruang terjadi kerusakan dengan munculnya gas dalam botol dan aroma tidak lagi segar.
AFIKSASI DALAM RUBRIK DESTINASI MAJALAH DERAP GURU DAN IMPLIKASINYA TERHADAP PEMBELAJARAN BERITA KELAS VIII SMP
Authors: Restu Aulia Hanindya , Kustriyono Erwan , Ristani Yulita Rohmah , Putri Putri
Published: September 2023

Penggunaan bahasa yang digunakan dalam komunikasi lisan dan tulis berbeda. Diperlukan penghayatan yang mendalam dan referensi penggunaan bahasa sesuai tata bahasa. Proses afiksasi merupakan salah satu tata bahasa yang harus dikuasai dalam penggunaan bahasa oleh pengguna bahasa agar dapat melakukan komunikasi secara efektif. Penulisan wacana, terutama teks berita dalam rubrik Destinasi majalah Derap Guru menuntut editor dapat melakukan komunikasi tulis secara efektif sehingga dapat menyampaikan informasi secara akurat dan komunikatif. Berdasarkan hal tersebut, dilakukan penelitian mengenai proses afiksasi dalam rubrik Destinasi majalah Derap Guru yang dapat digunakan sebagai salah satu referensi dalam penggunaan bahasa. Kemudian implikasi dari hasil penelitian dapat digunakan dalam pembelajaran berita yang dilakukan di kelas VIII SMP. Penelitian ini berjenis penelitian deskriptif kualitatif. Kajian diulas dengan pendekatan kualitatif. Penelitian ini mengkaji afiksasi dalam rubrik Destinasi majalah Derap Guru edisi bulan Mei hingga Oktober 2020 dan implikasinya dengan pembelajaran berita kelas VIII SMP. Berdasarkan pemaparan tersebut, maka penelitian ini dapat disimpulkan, sebagai berikut: Pertama, berdasarkan hasil penelitian di atas ditemukan tiga jenis afiksasi, yaitu prefiks, sufiks, dan konfiks dalam rubrik Destinasai majalah Derap Guru edisi bulan Mei hingga Oktober 2020 berjuml;ah 58 data dengan rinciannya yaitu 20 data yang dikenai konfiks, 19 data yang dikenai sufiks, dan 19 data yang dikenai prefiks. Kedua, Afiksasi dalam rubrik Destinasi majalah Derap Guru dan implikasinya pada pembelajaran berita yang dilakukan di kelas VIII SMP yaitu dapat dimanfaatkan sebagai pembelajaran Bahasa Indonesia kelas VIII SMP, khususnya dalam pembelajaran teks berita tentang Kompetensi Dasar 3.2. Menelaah Struktur dan Kebahasaan Teks Berita.
Aula invertida, ¿qué recursos educativos digitales mejoran el desempeño de los estudiantes? Una aproximación fsQCA
Authors: Mendaña-Cuervo Cristitablana , Remo-Díez Nieves , López-González Enrique
Published: September 2023

El entorno actual de los procesos de enseñanza, con la utilización de plataformas de aprendizaje, pone a disposición de los docentes la posibilidad de implementar recursos educativos muy variados, para su utilización tanto en el aula como para apoyar a los estudiantes en su aprendizaje autónomo. En este trabajo se plantea evaluar qué recursos didácticos de los implementados en un curso impartido bajo la metodología de aula invertida suponen un mejor resultado académico. Para ello, se planteó la oportunidad de utilizar la técnica fsQCA, con el fin de conocer aquellas combinaciones de recursos que facilitan la obtención de un mejor desempeño de los estudiantes.
ON CORRECT SOLVABILITY OF DIRICHLET PROBLEM IN A HALF-SPACE FOR REGULAR EQUATIONS WITH NON-HOMOGENEOUS BOUNDARY CONDITIONS
Authors: Khachaturyan Mikayel A.
Published: September 2023

In this paper we consider the following Dirichlet problem with non-homogeneous boundary conditions in a multianisotropic Sobolev space $W_2^{\mathfrak{M}}(R^2 \times R_+)$ $$\begin{cases} P(D_x, D_{x_3}) u = f(x, x_3), \quad x_3 > 0, \quad x \in R^2, \\ D_{x_3}^s u \big\rvert_{x_3 = 0} = \varphi_s(x),\quad s = 0, \dots, m-1. \end{cases} $$ It is assumed that $P(D_x, D_{x_3})$ is a multianisotopic regular operator of a special form with a characteristic polyhedron $\mathfrak{M}$. We prove unique solvability of the problem in the space $W_2^{\mathfrak{M}}(R^2 \times R_+)$, assuming additionally, that $f(x, x_3)$ belongs to $L_2(R^2 \times R^+)$ and has a compact support, boundary functions $\varphi_s$ belong to special Sobolev spaces of fractional order and have compact supports.
OLIVINE-BASED SORBENTS FOR REMOVAL OF HEAVY METALS
Authors: Hayrapetyan Sergey  S. , Hayrapetyan Martin S. , Khachatryan Hambardzum H.
Published: September 2023

Inductively coupled plasma mass spectrometry (ISP-MS) and scanning electron microscope-X-ray fluorescence (SEM-XRF) methods were used for the investigation of olivine sorption properties. It has been shown, that olivine may be applied as a cheap and available material for the sorption of metals, including heavy metals, from wastewater. The comparatively low sorption capacity of olivine may pay off by its accessibility and cheapness. The mechanism of adsorption on the olivine surface may be described as the substitution of magnesium ions by cations of various metals. One trend can be fixed – when ionic radius of the metal cations increases, their sorption increases as well. However, it is hardly possible to tie everything with the ionic radius of metal ion. The specificity of each element is also important.
CHIRAL SEPARATION OF $(2S,~9S)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID AND $(2R,~9R)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID
Authors: Tsaturyan Avetis H.
Published: September 2023

The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid were separated by a chiral high-performance liquid chromatography (HPLC) method. The separation of α-amino acids was performed using a 5µ 4.0×250 mm column, which was obtained on the basis of a sorbent with eremomycin. The sorbent is silica gel (with 11 nm pore diameter and a surface area of 300 m2/g) with epoxy groups grafted on them with antibiotic eremomycin. Chiral HPLC is one of the most common methods for separating enantiomers of chiral compounds. Synthesis of new pharmaceutical substances, which are one of the isomers of a substance, obtaining of new drugs based on them, as well as the need to control the presence of the second isomer in such drugs, impose new requirements on the modern chromat-ographic separation of isomers.
CLASSIFIED MEDICINAL PLANTS OF CANAKKALE IN THE TROYA REGION AND THEIR USAGE AREAS
Authors: Tutenocakli Tulay
Published: September 2023

In this study, plants with medicinal properties were determined from the plants, which are included in the Flora of Turkey and The East Aegean Islands books, grown in Canakkale, located in the Troy region. The purposes of use of the plants used for treatment in Canakkale center and districts, the active substances they contain and their usage patterns are listed. As a result, 93 plant taxa with medicinal properties that naturally spread in Canakkale were identified. It contains 40 taxa essential oil, 26 taxa tannins, 19 taxa fixed oil, 15 taxa glycosides, 8 taxa alkaloids, 7 taxa organic acids from plants used for therapeutic purposes. Medicinal plants found in Canakkale are diaphoretic, diuretic, gas-reducing, potent, antidiabetic, antipyretic, wound healing, pain reliever, bile enhancer, stone reducer, etc. are used for such purposes. It is use the taxa, 54 are used as infusions, 22 as decoctions, 15 as powders, 2 as pills, 6 as ointments and 5 as mouthwash.
A Pilot Clinical Study on the Efficacy of Bilvamuladi Kwatha Aschyotana in the Management of Kaphaj Abhishyanda w.s.r. to Bacterial Conjunctivitis
Authors: Katwate Dipali Dipak  , Kotangale Sumedha Yogesh
Published: September 2023

Bacterial conjunctivitis is one of the most common ocular diseases that occurs worldwide and affects every age group and social strata. The disease Kaphaj Abhishyanda, which is due to vitiation of Kapha Pradhana Tridosha is comparable with this condition. In the management of bacterial conjunctivitis as per modern ophthalmology antibiotic and antihistaminic eye drops are prescribed. Because of recurrent use of antibiotics, chances of antibiotic resistance are increasing. The present study was planned to evaluate the management of same disease with Ayurvedic formulation. Ayurveda can provide better alternative treatment in such manifestation. Ayurvedic formulation mentioned in Ashtanga Sangraha on Kaphaj Abhishyanda was selected and the Bilwamuladi Kwatha was prepared for Aschyotana as mode of administration. 3 patients diagnosed with Kaphaj Abhishyanda were selected and given Bilwamuladi Kwatha Aschyotana 1 drop twice a day for 7 days. The assessment of symptoms was done before, during the treatment and after treatment. The Bilvamuladi Kwatha has Ushna Veerya and Kaphaghna properties, which helps in treating vitiated Kapha Dosha as well as Madhu and Shigru are known to be Chakshushya. Bilvamuladi Kwatha was found effective with significantly reducing symptoms of Kaphaj Abhishyanda and shows marked difference in bacterial culture and sensitivity testing of conjunctival smear, which is studied as objective parameter.
Agnikarma - Understanding the process from Past to the Present
Authors: Aditya Sharma  , Neha Chauhan  , P. Hemantha Kumar  , Suman Sharma  , Lokendra Pahadiya
Published: September 2023

Throughout human history, medical practices have evolved and adapted to the prevailing knowledge, culture, and technology of their time. One such ancient medical technique that holds a significant place in history is "Agnikarma," a fire-based therapeutic intervention. Originating in civilizations such as India, China, Greece, and Egypt, Agnikarma's evolution and significance are explored within their cultural and medical contexts. Its origins are traced to ancient medical texts, including the "Sushruta Samhita" and the "Huangdi Neijing," which document its application in Ayurvedic and Traditional Chinese Medicine (TCM), respectively. Agnikarma's role in treating a wide array of conditions, from pain relief to chronic ailments, is examined, reflecting its diverse applications across cultures. Agnikarma involves the application of heat to specific points on the body using a variety of instruments, such as metal rods, needles, and cow dung cakes. By stimulating blood circulation and promoting the body's natural healing process, Agnikarma has been used to address conditions ranging from musculoskeletal pain to skin disorders. An attempt is made using this article to review how the process started from being worshipped like God to a therapeutic procedure, the step-by-step development. This review article explores the historical origins and contemporary use of Agnikarma therapy. The article also discusses the future directions for the research and development of this ancient healing technique. In essence, this historical review illuminates Agnikarma's cultural significance, medical impact, and role in shaping the trajectory of medical practices through time.
Multidimenstional View of Hypothyroidism Through Ayurveda w.s.r to Anukta Vyadhi
Authors: Yash Patel  , Shah Shivani  , Shivaranjani Kantharia
Published: September 2023

Hypothyroidism is a condition characterized by a lack of thyroid hormone (T3 and T4), which can be caused by a variety of factors. The prevalence of this condition is on the rise globally due to increased levels of stress and strain. The symptoms of hypothyroidism are studied in terms of imbalance of Dosha, Dushya, Srotasa, etc and an effort is made to obtain standard possible Samprapti and Samprapti Ghataka of the same disease. All Srotas are involved in the analysis of the signs and symptoms associated with hypothyroidism from the Ayurvedic perspective. The Vata Dosha and Kapha Dosha Vriddhi are elicited and Pitta Dosha Kshaya is seen. Here an attempt is made to understand hypothyroidism as a Vyadhishankarya from Ayurvedic point of view. Aims and Objectives: 1. To study the Samprapti of hypothyroidism through Ayurveda. 2. To study the Samprapti Ghataka of hypothyroidism through Ayurveda. Material and Method: Hypothyroidism has been studied using modern pathology textbooks from different authors, as well as looking up online medical research from places like PubMed, Google Scholar, and other national databases. The study of various Ayurvedic Samhita were made critically and an effort is made to understand the complete Samprapti and Samprapti Ghataka of hypothyroidism in terms of Dosha, Dushya, Agni, and Srotas etc. The modern lifestyle and sedentary lifestyle lead to aggravation of Vata Dosha, and Kapha Dosha cause the Jathragnimandhya with the formation of Ama, Rasadhatavagni depends on Jatharagni, so Dhatvagnimandhya occur and causes improper formation of Sapta Dhatu starting from Rasa to Shukra and improper Dhatu Vriddhi (especially Meda Dhatu). In Dhatvagnimandhya especially Rasa Dhatvagnimandhya leads to Sama rasa Vriddhi and over production of Mala of Rasa Dhatu i.e., Mala rupa Kapha Dosha Vriddhi. Majority of the Nanatmaja Roga of Kapha Dosha can be included as signs and symptoms of hypothyroidism.
A Review on Relevance of Pramana Pariksha (Physical Anthropometry)
Authors: Seetharama Mithanthaya  , Swati Bedekar
Published: September 2023

The estimation of Bala on the basis of Pramana (Physical anthropometry) is one of the glorious concepts of Ayurveda. The Pareeksha of Atura Deha before performing his Chikitsa plays a significant role in the proper assessment of Rogi with respect to his Bala and Ayu. Pramana (physical anthropometry) is mainly assessed by Swa-Angula, which is taken as the unit of measurement of the body parts and structures with respect to length, breadth, height, and circumference. Anthropometry explains about average height, and breadth of a person and his body parts with the help of different measuring units like cm, inch, etc, but applying average will not serve the purpose in every situation as anthropometric measurements are supposed to get influenced by different circumstances like gender, race, place and time, etc. The “Swa-Angula Pramana (physical anthropometry)” is an ideal parameter irrespective of gender, race, and place. The growth of the body varies at different ages and gets ceased after a particular stage. Anguli Pramana (physical anthropometry) is a unit of measure followed in the olden days to denote the dimensions of any object which includes Ayama (length), Vistara (width), Parinaha (circumference), Utsedha (height), etc. An individual with Anga-pratyangas having proper measurements is endured with longevity, wealth, prosperity, happiness, Ojas, strength, etc.
Comparative Clinical Evaluation of Rasnasaptak Kwath and Vaitarana Vasti in the Management of Amavata (Rheumatoid Arthritis)
Authors: Narendra Kumar Gautam  , Aparnesh Pandey  , O.P. Singh
Published: September 2023

Amavata is one of the challenging diseases for the physicians due to its chronicity, incurability, complications and morbidity. It is decided to evaluate certain Ayurvedic management for a series of patients of rheumatoid arthritis which could be safe, effective, cheap, and easily available. Methodology: Total 56 patients of RA (Amavata) fulfilling the inclusion criteria and having symptoms of RA were enrolled for clinical trial from OPD & IPD of department of Kayachikitsa, SS Hospital, IMS, BHU, Varanasi. Patients were treated in four different groups- Group A- 18 clinically diagnosed and registered patients of Amavata were treated by- Rasnasaptak Kwath- 40ml BD with lukewarm water. Group B: 16 clinically diagnosed and registered patients of Amavata were treated by Vaitarana Vasti for 2 times at interval of 15 days in the format of Yoga Vasti with Anuvasana of Saindhavadi Talia. Group C: 5 clinically diagnosed and registered patients of Amavata were treated by- Rasnasaptak Kwath and Vaitarana Vasti. Group D: 17 clinically diagnosed and registered patients of Amavata were treated by- Leflunomide 10mg OD Results: After the trial, treatment given for the clinical study, we got Vata-Kapha trait appears to be more vulnerable for Amavata disease. Overall effect of trial suggests that group C provided better improvement in comparison to group A, B and D in maximum objective and subjective criteria. Discussion: The study concludes that, planned trial drugs and procedure are effective in terms of reduction of symptomatology of Amavata (RA) as compared to standard treatment group.