bluuebunny/crossref_metadata_2025 huggingface dataset:
Gasmessgeräte mit System managen
Authors: Weich Rüdiger
Published: October 2023

Die Software-Lösung ›Gas Detection Connect‹ von Dräger vernetzt mobile Gasmessgeräte und automatische Prüfstationen zu einem intelligenten System, das Industrieanlagen eine digitale Verwaltung ihrer Gasmessgeräte ermöglicht. Das System speichert Prüfergebnisse, Gerätestatus und Berichte direkt in einer Cloud, um sie zentral verfügbar zu machen. Neuester Bestandteil des Systems ist das das mit Bluetooth ausgestattete Mehrgasmessgerät X-am 5800 für die persönliche Überwachung.
Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one
Authors: Nimz Jonathan-Gabriel , Rerkshanandana Pichayut , Kloypan Chiraphat , Kalus Ulrich , Chaiwaree Saranya , Pruß Axel , Georgieva Radostina , Xiong Yu , Bäumler Hans
Published: October 2023

Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in common that they are affected by degradation and excretion at an early stage in test organisms. Several possible mechanisms that may be responsible for this are discussed in the literature. One of them is CD163, the receptor of the complex of haptoglobin (Hp) and hemoglobin (Hb). The receptor has been shown in various studies to have a direct affinity for Hb in the absence of Hp. Thus, it seems reasonable that CD163 could possibly also bind Hb within HBOCs and cause phagocytosis of the particles. In this work we investigated the role of CD163 in the uptake of our hemoglobin sub-micron particles (HbMPs) in monocytes and additionally screened for alternative ways of particle recognition by monocytes. In our experiments, blockade of CD163 by specific monoclonal antibodies proved to partly inhibit HbMP uptake by monocytes. It appears, however, that several other phagocytosis pathways for HbMPs might exist, independent of CD163 and also Hb.
Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect
Authors: Nakashima Ken-ichi , Abe Naohito , Oyama Masayoshi , Murata Hiroko , Inoue Makoto
Published: October 2023

Breynia spp. are a key source of sulfur-containing spiroketal glycosides with potential anti-inflammatory activity. In this study, three new sulfur-containing spiroketals – breynin J (1), epibreynin J (2), and probreynogenin (3) – along with four known compounds – probreynin I (4), phyllaemblic acid (5), breynin B (6), and epibreynin B (7) – were isolated from the roots of Breynia disticha. The structures of compounds 1–7 were elucidated by extensive 1D and 2D NMR spectroscopic analyses, including 1D total correlation spectroscopy (TOCSY), HSQC, HMBC, double quantum-filtered (DQF)-COSY, heteronuclear two-bond correlation (H2BC), and HSQC-TOCSY experiments, as well as high-resolution electrospray ionization HRESIMS analysis, and quantum chemical electronic CD calculations. Furthermore, the absolute configurations of sugar residues were determined by derivatization of the hydrolysates with ʟ-cysteine methyl ester and o-tolyl isothiocyanate followed by HPLC analysis. The anti-inflammatory effects of the isolated compounds were evaluated based on the mRNA levels of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells. Compounds 1, 2, 6, and 7 inhibited the increase in interleukin (IL)-1β and IL-6 mRNA levels stimulated by LPS. Moreover, the most potent compound 7 was found to significantly inhibit the production of IL-1β and IL-6 proteins, as revealed by the analysis of culture supernatants.
Osmanlı Süreli Çocuk Yayınlarında Çocukluk ve Eğitim Anlayışı "Çocuk Dostu" Örneği
Authors: Gurbetoğlu Ali
Published: October 2023

Çocuk Dostu (1914), Türkiye’de okulöncesi kademesi çocukları için çıkarılan ilk çocuk dergisidir. Dergi tarihsel malzeme olarak dönemin imkanlarını ve çocukluk anlayışını yansıtması yanında Türk çocukluk tarihi açısından da önemli bir belgedir. Dergi araştırmacılarca genel değerlendirmelerin dışında geniş bir incelemeye tabi tutulmamıştır. Dönemin eğitim anlayışı ve çocuk paradigmasını anlama açısından, dergi içeriğinin incelenmesi önemlidir. Nitel araştırma yönteminin uygulandığı çalışmada çocukluk kavramı, çocuklara yönelik süreli yayınların işlevleri ve dönemin çocuk dergiciliği kısaca incelenmiş, derginin eğitim açısından önemi değerlendirilmiştir. Biçimsel açıdan derginin yayın bilgileri, hedef kitlesi, amacı-önemi, içerik açısından da görselliği, başlıca konuları eğitici-öğretici yönü incelenmiştir. İncelemede derginin tüm sayıları kullanılmıştır.
Derginin genel söylemi, çocuğa görelik boyutu, amaç-içerik uyumu, içerdiği sakıncalı mesajlar değerlendirilmiştir. İçerikten, hedef kitlenin bilgi sahibi, araştırmacı, azimli, girişimci, dürüst, çalışkan, paylaşımcı ve vatansever duygularla yetiştirilmesinin hedeflendiği görülmüştür. Çağdaşı diğer çocuk dergilerine göre dönemin olumsuz şartlarından kaynaklı pedagojik sakıncalardan önemli ölçüde uzak durmayı başarmıştır. Biçim ve içeriğiyle çağdaş çocuk yayıncılığı anlayışıyla uyumlu olduğu görülmüştür. Çocuklara sunduğu içeriklerle bir yönüyle çocuk merkezci diğer yönüyle geleceğin yetişkini anlayışını sergilemiştir. Bu bakımdan “Romantik” ve “Protestan” çocukluk anlayışından etkilenerek iki kulvarda gelişmiş olan 20.yüzyıl çocuk paradigmasına uyumlu bir yayın olduğu söylenebilir. Dergi ait olduğu dönemin çocuk yetiştirme imkanları ile model insan anlayışı konusunda kanaat oluşturmaya yardımcı bir belge nitelindedir. Bu bakımdan çalışmanın Türk eğitim ve çocukluk tarihi literatürüne önemli katkısı olacağı umulmaktadır.
The Use of Canva and Powtoon Learning Media in Learning Poetry Materials to Improve Student Learning Outcomes for High School
Authors: Choirunnisa Adinda , Yulandari Esti , Tanjung Muhammad Arif Alamsyah , Afifah Riski Aprilia Nur , Kusnasari Zanida
Published: October 2023

This study aims to test the effectiveness of Canva and Powtoon learning media in learning poetry material to improve student learning outcomes in class X IPA 1 SMAN 1 Kelapa Kampit. The research subjects were class X IPA 1 students at Kelapa Kampit State Senior High School. The method used in this research is research and development. The application of information technology-based learning materials is expected to improve teaching standards in the classroom. The study results show that the Canva and Powtoon learning media are appropriate for learning Indonesian for class X IPA 1 SMA Negeri 1 Kelapa Kampit. This is because it meets the requirements for media validation, material validation, and evaluation validation. The pretest and posttest results found that Canva and Powtoon media helped class X IPA 1 SMA Negeri 1 Kelapa Kampit understand the material needed to recognize the atmosphere, themes, and meaning in the poetry anthology. Based on this, the Canva and Powtoon learning tools can be developed in teaching Indonesian, especially when teaching students how to recognize the atmosphere, themes, and meaning of poetry anthologies.
Improving Student's Vocabulary Mastery Through Hello English Application at Tenth-Grade Students of High School
Authors: Ulfa Ulfa , Wiyaka Wiyaka , Wahyuni Sri
Published: October 2023

This study aims to determine 1) the effect of using the Hello English application in English teaching on improving students' ability in vocabulary mastery and 2) determine students' perceptions of the application of Hello English application in teaching English subjects at SMAN 1 Mayong, Jepara. This study used a type of quantitative research with a pseudo-experimental research design. This study used test data collection techniques and questionnaires to measure students' vocabulary mastery. The population of this study was grade X students of SMAN 1 Mayong, with a total of 72 students consisting of grades X 7 and X 9. The test result data in this study was calculated and analyzed automatically using SPSS. Based on the data analysis using the t-test, the test data shows that the result of t count (df = 70) = 9.881 and p-value or significant level of 0.000, which is smaller than 0.05. Researchers use α = 0.05 (5%) as a significant standard, so the null hypothesis (Ho) is rejected, and the alternative hypothesis (Ha) is accepted because the p or sig (2-tailed) value of 0.000 is lower than α = 0.05 (5%). This means a significant difference exists between the results of using the Hello English Application in teaching vocabulary to grade X students of SMA Negeri 1 Mayong for the 2022/2023 school year. The results showed that the Hello English application significantly increased students' vocabulary mastery after treatment. The average score of experimental class students increased from 73 on the pre-test to 91 on the post-test.Moreover, the control class's average score was 74 on the pre-test to 79 on the post-test. This means that the average score of the students in the experimental class is higher than the average score in the control class. Researchers concluded that the Hello English Application is effective through mastery of student vocabulary, especially for tenth-grade students of SMA Negeri 1 Mayong for the 2022/2023 academic year. Based on the questionnaire, the results showed that using the Hello English application in teaching English has many positive impacts on students, including students being more motivated in learning and making it easier for students to understand the material.
Estrategia de Ehrlichia Chaffeensis para Evitar el Mecanismo de Defensa Celular en Ehrlichiosis Monocítica Humana
Authors: Delgado Arellano Nayelli , Hernández Jiménez José Bernardo
Published: October 2023

Introducción.  Existen diferentes vectores en la transmisión de enfermedades en los animales y el humano; después de los mosquitos, las garrapatas son el segundo vector, los cuales son motivo de preocupación para la salud pública, por su morbilidad y mortalidad en seres humanos alrededor del mundo. Por ejemplo la Ehrlichiosis monocítica la pueden padecer tanto perros como humanos, transmitida por Ehrlichia canis y Ehrlichia chaffensis, es una bacteria Gram negativa obligatoria intracelular. Estas son transmitidas por dos especies de garrapatas: Rhipicephalus sanguineus vector de la Ehrlichia canis y Ambyloma americanum para E.Chaffeensis quien origina Ehrlichiosis Monocítica Humana la cual es una enfermedad infecciosa febril emergente transmitida por la mordedura de garrapatas y latentemente mortal.  Objetivo.  Describir la enfermedad, mecanismo de transmisión y la estrategia principal de Ehrlichia chaffeensis para evitar el mecanismo de defensa en leucocitos causado en Ehrlichiosis Monocítica Humana.  Metodología: Revisión descriptiva por medio de una búsqueda en la literatura en diversas bases de datos Google Académico, PubMed, SciELO, Redalyc, utilizando los términos “Ehrlichiosis Monocitica Humana”, “Ehrlichia Chaffensis”.  Resultados y conclusión: se revisaron y consultaron artículos científicos, encontrando la estrategia de Ehrlichia Chaffensis, distribución, mecanismo de transmisión, patogenia, cuadro clínico y diagnóstico de la Ehrlichiosis Monocitica Humana.
The Effect of Training Program Given to Multiple Pregnants by Motivational Interview Method on Fear of Birth and Delivery Style
Authors: ALKAN AKALIN Senem , ÖCAL Ece , ÖZÇELİK OTCU Serap Mutlu
Published: October 2023

Aim: Within the scope of our research, it was aimed to evaluate the effects of the training programs given with the motivational interview attitude given specifically to the mothers with multiple pregnancies on possible fears of childbirth and self-perception. In this direction, case and control studies were conducted with two groups. In summary, it focused on the effect of self-efficacy experienced during birth and self-efficacy experienced at the same time.

Material and Methods: Our study was carried out between August 2022 and November 2022 in Adana Seyhan State Hospital Obstetrics and Gynecology Polyclinic with 73 multiple pregnant women (intervention: 37, control: 36) who met the study. More than one pregnant mother in the sample was randomly selected according to the intervention and control groups. "Training Program Based on Motivational Interview Method for Fear of Birth" was given to 37 pregnant women in the case group, four sessions individually, once a week.

Results: In obtaining the relevant data within the scope of our study; Descriptive Personal Form, Wijma Birth Expectation/Experience Scale (W-DEQ) Versions A and B, Birth Self-Efficacy Scale (DSS) Short Version and Birth Evaluation Form were used. During the evaluation of the data, descriptive statistics such as the number of patients and the percentage of gender were recorded. Data are shown as mean±standard deviation, median (percentage). Chi-square test, Independent Groups t test, Mann Whitney U test, Wilcoxon test, repeated measures ANOVA test and Friedman test were used in statistical analysis.

Conclusion: In the training program conducted with the motivational interview approach with pregnant mothers, it was revealed that possible fears of birth were minimized, positive increases were observed in birth self-efficacy, and the effect on birth types was not much. Looking at the results of the research; In order to minimize the fear of birth in the prenatal period and to increase self-efficacy during birth, it is recommended to include it in nursing care in a training program based on the motivational interview approach for fear of birth.
Evaluation of Demographic and Clinical Characteristics of the Patients with Syphilis Who Applied to the Dermatology Clinic of a Tertiary Referral Hospital Between the Years 2019-2023
Authors: ERDURAN Funda
Published: October 2023

Aim: The aim of this study is to evaluate the demographic and clinical features of syphilis patients followed up in a tertiary referral hospital, and thus to provide current contributions to epidemiological data related to syphilis.

Material and Methods: The demographic characteristics, clinical and laboratory findings, and treatments received of all patients diagnosed with syphilis and followed up in our clinic between January 2019 and June 2023 were evaluated retrospectively.

Results: We included a total of 118 patients, 24 women and 94 men. The average age of the patients was 36.56±5.1 years. Forty-one of the patients (34.7%) were married, 56 were single (47.4%) and the marital status of 21 (17.8%) was unknown. Sixty-two of the patients (52.5%) had primary syphilis , 29 (24.6%) had secondary syphilis and 27 (22.9%) had latent syphilis. When the patients' admission symptoms were evaluated, genital chancre was found in 58 (49.1%), roseola syphilitica in 24 (20.3%), mucous plaque in 11 (9.3%), condyloma lata in 7 (5.9%) and syphilis papulosa psoriasiformis in 3 (2.5%) patients. Twenty-five patients (21.1%) were asymptomatic. Transmission from spouse was in 14 (11.9%) patients while suspicious sexual contact was in 77 (65.3%) patients. The source of transmission was unknown in 27 (22.9%) patients. Response to treatment was obtained in all of the patients who were not lost to follow up. Twenty-two of the patients (18.64%) were HIV positive.

Conclusion: Rising syphilis incidence which is observed globally in the recent years indicates the need to raise the level of public awareness about the disease and its transmission routes. In addition, since it can mimic many diseases, it should always be considered in the differential diagnosis, especially in patients with a history of suspicious sexual contact. It is necessary to investigate other sexually transmitted diseases, especially HIV, in patients diagnosed with syphilis.
Role of SARS-CoV2 Virus in the Etiology of Acute Pancreatitis
Authors: KIZILOĞLU İlker , DERELİ AKDENİZ Didem , UĞUR KANTAR Funda
Published: October 2023

Aim: To investigate whether severe acute respiratory syndrome coronavirus is involved in the etiology of acute pancreatitis.

Material and Methods: This study was conducted in Çiğli Educational Hospital, Bakırçay Univesity. The study included 2060 patients with AP admitted to hospital between March, 2020 and August, 2023. The patients were assigned into 2 groups based on presence of COVID-19 infection. Ethiological factors for AP were determined in all patients.

Results: Gallstone was the etiological factor in 614 patients (32.9%) who were COVID (-) but it was the etiological reason in only 19 patients (19%) in COVID (+) group. No etiology was identified in 217 (11.6%) of COVID (-) patients who were diagnosed as idiopathic pancreatitis. Idiopathic pancreatitis was diagnosed in 107 cases (54%) in COVID (+) group. There was significant difference presence of the diagnosis, which was made according to etiological factor, between groups.

Conclusion: There was no definitive etiological link between COVID-19 and AP; however, the fact that same team diagnosed such a different idiopathic AP in the same hospital with same diagnostic facilities implies an etiological role for SARS-CoV-2 virus in AP.
Investigation of Work Motivation and Anxiety Levels of Trainers Working in Antalya
Authors: KARADEMİR Mehmet Bilgin
Published: October 2023

The universe and sample of this research, which was carried out with trainers working in individual and team sports, consists of a total of 163 trainers actively working in 50 sports branches in Antalya. Within the scope of the research, the work motivation scale whose validity and reliability studies were conducted by Yılmaz (2012) and the state and trait anxiety scale adapted to Turkish by Öner and Le Compte (1983) were used. The SPSS 26 package program was used in the analysis of the data obtained in this study, in which participation was made on a voluntary basis, and it was determined that the data provided a normal distribution. In this context, independent sample t-test from parametric tests and one-way analysis of variance (ANOVA) were used in the study. Homogeneity of variances was found to be significant with Levene's test. For this reason, Scheffe test was used in multiple comparisons. The relationship between work motivation and anxiety was examined by Pearson correlation analysis.

As a result of the research carried out with individuals actively coaching in team and individual sports branches; It has been determined that as the anxiety levels of the coaches decrease, there is an increase in the work motivation levels.
Opinions of the Top Managers of the Ministry of National Education on the Implementation of Physical Education Policies in Schools
Authors: TEKİN Nedim , ERCAN Özge
Published: October 2023

"World Physical Education Summit" was held in Berlin in 1999. In the summit, participants from more than 80 countries have determined the policies and reforms for the common solution of all problems related to physical education teaching. At the end of the Berlin Summit, the policies and reforms related to physical education have reconsidered and regulated in many countries. As it is well known, the firstly responsible agency in teaching physical education policies in Turkey is the Ministry of National Education (MEB). Therefore, in this study, it is aimed to reveal the views of the top level managers of the MEB. In this study, phenomenology design which is one of the qualitative research methods has been used. The study group of the research consists of 11 senior managers working in the Ministry of National Education. The data have been analyzed using the semi-structured interview technique and content analysis method. According to the findings of the research, MEB senior managers have listed the components of a quality physical education program as teachers, school administrators, equipment and physical conditions (facility, hall, etc.). They have stated that the biggest obstacles for the physical education curriculum to reach the desired goals are the inadequacy of tools and equipment in schools, the unsuitability of physical conditions, and the fact that the same types of schools do not have the physical conditions at similar standard. They considered the goals and strategies in the development and implementation of physical education curriculum as physical and academic collaborations.
Model Pembelajaran Berintegritas: Praksis Model Pembelajaran Yesus dalam Alkitab Bagi Para Pendidik Kristen
Authors: Maryanto Jaka
Published: October 2023

Pada saat ini para pendidik Kristen perlu untuk fokus pada tugas dan fungsinya sebagai pendidik untuk menghasilkan peserta didik yang berkualitas dan perlu menyadari bahwa mengajar merupakan pelayanan atau perintah Ilahi yang perlu dilakukan dengan penuh rasa integritas tinggi. Keteladanan Yesus sebagai sosok Guru Agung harus menjadi dasar motivasi bagi semua pendidik Kristen untuk menjadi pendidik yang berintegritas sehingga mampu membawa peserta didik untuk bertumbuh dalam pengenalan akan Kristus. Metode penelitian yang dipakai dalam penulisan ini adalah deskriptif kualitatif dengan pendekatan studi literatur, di mana integritas Yesus sebagai pengajar tampak dalam beberapa hal, yakni: bertanggungjawab, tulus, jujur dan penuh kasih serta setia.
Analisis Hukuman atas Ananias dan Safira Versus Anugerah Pengampunan Dosa
Authors: Prananto Prananto , Sumiwi Asih Rachmani Endang
Published: October 2023

Dalam Alkitab yaitu Kisah Para Rasul 5:1-11 dituliskan kisah tentang hukuman Allah atas Ananias dan Safira yang menyebabkan kematian mereka berdua merupakan peristiwa yang unik dan khusus. Peristiwa tidak bisa digeneralisasikan di setiap kejadian yang mirip atau sama. Mengapa hukuman Allah ditimpakan kepada mereka tanpa diberi kesempatan untuk bertobat dan menerima anugerah pengampunan dosa dari Allah? Dosa seperti apa yang menyebabkan Allah murka kepada mereka? Apakah anugerah pengampunan dosa dari Allah tidak berlaku atas Ananias dan Safira? Dengan menggunakan metode kualitatif deskriptif yang berupa penelitian kepustakaan, peneliti mencoba memaparkan jawaban atas pertanyaan tersebut di atas. Dari hasil penelitian menunjukkan bahwa di tengah-tengah sedang dibangunnya jemaat mula-mula menjadi saksi Kristus yang tulus dan kudus maka Allah sangat menjaga kekudusan mereka. Allah tidak berkenan atas perbuatan Ananias dan Safira yang menodai kemurnian jemaat mula-mula. Mereka berdua mencobai Allah yang dengan sengaja dan terencana mendustai Roh Tuhan. Sekalipun Ananias dan Safira merupakan bagian dari jemaat mula-mula, namun dari apa yang dilakukannya menunjukkan bahwa mereka berdua tidak sungguh-sungguh bertobat, bahkan hati mereka dikuasai Iblis yang dengan sengaja melawan Allah sehingga anugerah pengampunan dosa dari Allah tidak dialami oleh Ananias dan Safira. Anugerah pengampunan dosa dari Allah diberikan dan dialami oleh setiap orang yang sungguh-sungguh bertobat dan menjadi percaya kepada Yesus Kristus sebagai Tuhan dan Juruselamatnya.
The Destiny of Dark Matter
Authors: Tracanna Fabiano , Hansen Steen H.
Published: October 2023

The majority of baryons, which account for 15% of the matter in the Universe, will end their lives as carbon and oxygen inside cold black dwarfs. Dark matter (DM) makes up the remaining 85% of the matter in the Universe; however, the fate of DM is unknown. Here we show that the destiny of purely gravitationally interacting DM particles follows one of two possible routes. The first possible route, the “radiation-destiny” scenario, is that massive DM particles lose sufficient energy through gravitational radiation, causing them to spiral into a supermassive black hole that ultimately disappears through Hawking radiation. The second possible route, the “drifting-alone” destiny, applies to lighter DM particles, where only the central DM halo region spirals into the central BH, which is then Hawking radiated away. The rest of the DM halo is ripped apart by the accelerated expansion of the Universe.
Polarization Evolution of Fast Radio Burst Sources in Binary Systems
Authors: Xia Zhao-Yang , Yang Yuan-Pei , Li Qiao-Chu , Wang Fa-Yin , Liu Bo-Yang , Dai Zi-Gao
Published: October 2023

Recently, some fast radio bursts (FRBs) have been reported to exhibit complex and diverse variations in Faraday rotation measurements (RM) and polarization, suggesting that dynamically evolving magnetization environments may surround them. In this paper, we investigate the Faraday conversion (FC) effect in a binary system involving an FRB source and analyze the polarization evolution of FRBs. For a strongly magnetized high-mass companion binary, when an FRB with ∼100% linear polarization passes through the radial magnetic field of the companion star, the circular polarization (CP) component will be induced and oscillate symmetrically around the point with the degree of CP equal to zero, the rate and amplitude of the oscillation decrease as the frequency increases. The very strong plasma column density in the HMCBs can cause CP to oscillate with frequency at a very drastic rate, which may lead to depolarization. Near the superior conjunction of the binary orbit, the DM varies significantly due to the dense plasma near the companion, and the significant FC also occurs in this region. As the pulsar moves away from the superior conjunction, the CP gradually tends toward zero and then returns to its value before incidence. We also investigate the effect of the rotation of the companion star. We find that a sufficiently significant RM reversal can be produced at large magnetic inclinations and the RM variation is very diverse. Finally, we apply this model to explain some polarization observations of PSR B1744-24A and FRB 20201124A.
A comparison of conventional and accelerated hypofractionated radiotherapy in definitive chemoradiation for locally advanced head and neck carcinoma: a retrospective cohort study
Authors: Tripathy Arkaja , Muzumder Sandeep , Srikantia Nirmala , Babu Ajay , Sebastian MG John , Udayashankar Avinash H. , Vashishta Ganesha Dev , Raj John Michael
Published: October 2023

Purpose: The study evaluates accelerated hypofractionated radiotherapy (AHRT) compared to conventional fractionation radiotherapy (CFRT) in patients with locally advanced head and neck cancer (LAHNC) receiving definitive chemoradiation therapy.Materials and Methods: The study includes a retrospective cohort analysis of 120 patients. CFRT arm (n = 65) received 2 Gy per fraction to a dose of 70 Gy over 7 weeks in a three-volume approach, whereas the AHRT arm (n = 55) received 2.2 Gy per fraction to a dose of 66 Gy in 6 weeks with a two-volume approach. The primary outcome was overall survival (OS). Results: With a median follow-up of 18.9 months, 23 patients died in the AHRT arm, and 45 deaths in the CFRT arm. The median OS was 23.4 and 37.63 months in the CFRT and AHRT arms, respectively (hazard ratio [HR] = 0.709; 95% confidence interval [CI], 0.425–1.18; p = 0.189). The median time to loco-regional control was 33.3 months in the CFRT arm and was not reached in the patient group receiving AHRT (HR = 0.558; 95% CI, 0.30–1.03; p = 0.065). The median progression-free survival was 15.9 months in the CFRT arm and 26.9 months in the AFRT arm (HR = 0.801; 95% CI, 0.49–1.28; p = 0.357). Out of 11 acute toxic deaths, eight were in the CFRT arm. Conclusion: The study showed a trend towards benefit in terms of locoregional control in the AHRT arm and similar OS. A longer follow-up of patients receiving AHRT is required to assess the benefit.
Targeting Proteus mirabilis BAM Complex Proteins for Development of Novel Antibiotics
Authors: Abban Raphael , Kwabena Sarpong , Duodu Samuel , Mosi Lydia , Abiola Isawumi
Published: October 2023

Urinary tract infections (UTIs) are frequent hospital-acquired infection, with Escherichia coli and Proteus mirabilis accounting for 90% of complicated UTIs. Emergence of multidrug-resistant (MDR) bacteria have complicated the treatment UTIs. P. mirabilis related UTIs has been associated with the production of urinary stones and long-term infections in patients with catheters. P. mirabilis and other uropathogens constitute a largely unexplored pathogen group. The pathogen is resistant to most antibiotics as a result of its impermeable outer membrane (OM). The β-barrel assemble machinery folds and inserts outer membrane proteins; however, there are no antibiotics targeting the OM assemble in clinical use currently. Therefore, this study seeks to identify drugs that will inhibit the activity of P. mirabilis B complex proteins and also determine their effects on P. mirabilis OM biogenesis. This would be achieved by screening approved drugs against the P. mirabilis Bam complex using computer-based in silico screening and cellular-based assays. First, the binding effects of drugs on P. mirabilis B complex proteins will be determined using docking algorithms. The antimicrobial and antivirulence activity of selected drugs from in silico analysis will be screened against MDR P. mirabilis. Finally, the effect of active drug(s) on the OM biogenesis of wild-type P. mirabilis and mutant P. mirabilis will be determined using peptide nucleic acids (PNA). Western lot analysis will be used to determine the abundance of proteins involved in OM biogenesis. Successful completion of this study will lead to the identification of novel antibiotics against MDR P. mirabilis and associated mechanisms while providing the foundation for future research endeavours on other uropathogens.
La frontière franco-britannique à Calais : des évolutions opérationnelles permanentes pour faire face aux enjeux internationaux
Authors: Billant Jacques
Published: October 2023

Calais a toujours été au centre des grands enjeux internationaux entre le Royaume-Uni et l’Europe, en raison de sa situation géographique, mais aussi de ses liens historiques avec la Grande-Bretagne. Le premier enjeu est économique avec deux plateformes transmanche – le port de Calais et le Tunnel sous la manche – qui agissent comme un vrai poumon économique aux niveaux local et régional. Calais est également l’épicentre d’une forte pression migratoire, au cœur des politiques et des relations gouvernementales françaises et britanniques, et dont la physionomie est changeante (problématique des « small-boats », troubles à l’ordre public…). Le Brexit a par ailleurs complexifié la gestion de la frontière franco-britannique de Calais en imposant désormais des contrôles sur les marchandises et les voyageurs, tout en assurant le défi de la fluidité du trafic qui est la base du modèle économique local. Si les différents accords entre la France et le Royaume-Uni ont permis d’avoir une frontière juxtaposée spécifique à Calais et d’accompagner financièrement la lutte contre l’immigration clandestine, c’est bien toujours grâce à l’adaptation des services de l’État et à la bonne coopération franco-britannique sur le terrain – au plan opérationnel et sur le volet du renseignement – que ces défis frontaliers peuvent être relevés au quotidien.
Les Pyrénées, une frontière dynamique pour une action renforcée de l’État
Authors: Durand Pierre-André
Published: October 2023

Frontière la plus longue de France métropolitaine, les Pyrénées demeurent un espace difficile à traverser en sa partie centrale mais aussi préservé par une riche biodiversité. Cette difficulté n’a pas empêché l’émergence très ancienne de bassins de vie entre la France et l’Espagne à l’est et à l’ouest de la chaîne pyrénéenne. Ces bassins de vie ont nécessité l’engagement de coopérations transfrontalières à différents niveaux de collectivités publiques (État, régions, communes). Si les coopérations de proximité des collectivités locales se veulent avant tout opérationnelles autour de sujets d’intérêts communs comme l’accès aux services publics (hôpital de Cerdagne), la frontière demeure un espace d’action renforcée de l’État. La permanence de circulations de flux illégaux (migrants, contrefaçons, stupéfiants et animaux notamment) dans la montagne pyrénéenne rend indispensable la conduite de contrôles et d’actions concertés entre les trois États (France, Espagne, Andorre). Les Pyrénées symbolisent la volonté forte et renouvelée de l’État de lutter contre les trafics en tout genre, mais en assurant la libre circulation des personnes et des biens dans des territoires à l’identité commune entre les deux États (Catalogne, Pays Basque). L’efficacité de l’État s’apprécie donc à sa capacité à maintenir une approche équilibrée de la gestion de la frontière.
Le Brésil, voisin de la Guyane et première frontière terrestre de la France
Authors: Paillard Christophe-Alexandre
Published: October 2023

La Guyane est à la fois le plus grand département français par sa superficie et celui qui possède la plus longue frontière terrestre, soit 730 km, qui fait du Brésil un voisin et un partenaire stratégique pour la France. Les récentes réunions du Comité interministériel des Outre-mer et de la Commission mixte de coopération transfrontalière franco-brésilienne ont mis en avant la variété et l’ampleur des sujets à traiter au niveau bilatéral. Malgré l’importance du sujet guyanais, cette question n’est cependant pas une priorité pour le Brésil qui fait face à des défis internes massifs et qui se cherche aujourd’hui un nouveau positionnement à l’international, par exemple au travers des rencontres des BRICS. Il est donc difficile, sur les sujets intéressant le plus la Guyane, en particulier les activités illégales venues du Brésil comme l’orpaillage ou la pêche clandestine, d’obtenir de nouveaux engagements de nos partenaires brésiliens, malgré l’existence d’une réelle bonne volonté de coopérer des deux côtés de la frontière de la rivière Oyapock.
Les opérations de la gendarmerie en forêt équatoriale guyanaise
Authors: Sintive Jean-Christophe
Published: October 2023

La gendarmerie nationale a toujours su s’adapter aux territoires qu’elle protège. En Guyane, elle fait face à des menaces spécifiques liées principalement à l’orpaillage illégal qui se propage au cœur de la forêt équatoriale. Pour y répondre et protéger les populations autochtones, ainsi que la biodiversité amazonienne, elle développe des savoir-faire particuliers et met en œuvre, en étroite coopération avec ses partenaires, une véritable stratégie de lutte multi-domaine qui évolue en permanence pour contrer un adversaire « garimpeiros » particulièrement résilient.
L’Europe et les frontières
Authors: Schott Cyrille
Published: October 2023

« Limites qui séparent un État d’un autre État » : c’est la définition lapidaire de la frontière retenue dans la seconde moitié du XIX e siècle par Émile Littré dans son dictionnaire de la langue française. Appliquée à l’Union européenne, qui n’est pas un État, cette vision si simple apparaît plutôt obsolète. La construction européenne a été bâtie sur le dépassement en son sein des frontières des États et à l’extérieur elle n’a cessé, en Europe sans frontière, de s’élargir pacifiquement. Toutefois, cette construction souffrant la diversité, des Europes avec des frontières différentes coexistent. Par ailleurs, face au phénomène des migrations humaines, l’Europe s’est repliée derrière ses frontières présentes et a exporté sa frontière. Plusieurs réalités se font jour lorsque l’on associe les termes Europe et frontière. Essayons de les saisir.
Le Lyon-Turin, un lien vital sous les Alpes qui se fait attendre
Authors: Lepine François
Published: October 2023

La liaison Lyon-Turin est la pièce manquante d’un puzzle beaucoup plus large. D’une longueur de 270 km, elle doit permettre de relier la France et l’Italie pour connecter les grands réseaux ferroviaires européens et faciliter le transport international des marchandises et des voyageurs. Près de deux millénaires après l’épopée d’Hannibal, et malgré les formidables progrès accomplis depuis, cette connexion est toujours fortement contrainte par la barrière physique des Alpes. Le Lyon-Turin ambitionne de s’en affranchir. Plus de vingt ans après la signature du premier traité franco-italien actant sa réalisation, le dossier a bien avancé. Il est toutefois régulièrement exposé aux risques d’erreurs d’aiguillages.
Liturgie et participation de la vie divine
Authors: Nassif Charbel
Published: October 2023

Cet article propose une lecture critique de l’ouvrage de Mgr Job Getcha paru en 2020 sur la spiritualité orthodoxe intitulé Participants de la nature divine. La spiritualité orthodoxe à l’âge de la sécularisation. Après avoir présenté les thèmes majeurs (spiritualité et vie liturgique, témoignage du Christ dans un monde sécularisé, la confession et la direction spirituelle, la création et la beauté) des différents chapitres, nous évaluerons cet ouvrage en s’attardant sur trois points évoqués par l’auteur : la langue liturgique, l’orthodoxie et l’inculturation et la sécularisation. Il est indispensable de traduire les textes liturgiques dans les langues modernes pour rendre la liturgie accessible aux fidèles orthodoxes et ce, tout en mettant en avant la nécessité de prendre en compte des éléments tels que l’hymnographie, l’architecture et l’iconographie pour rendre la liturgie compréhensible et participative. L’inculturation de la liturgie ne doit pas être négligée. La liturgie doit s’adapter à différentes cultures tout en préservant sa dimension spirituelle. La sécularisation doit être perçue comme inhérente au monde mais cela ne doit pas entraver la propagation du message évangélique.
Botanical Assessment of Remnant Floodplain Habitats Along Plaster Creek, Kent County, Michigan: Assessing Changes Since the 1890s
Authors: Weesies Haley R. , Crow Garrett E. , Warners David P.
Published: October 2023

Plaster Creek, a tributary of the Grand River, drains a 58-square mile watershed in Kent County, Michigan. Its headwaters originate in the agriculturally dominated southwestern portion of the county, and then it meanders through residential, commercial, and urban areas of Kentwood and Grand Rapids before it empties into the Grand River about one mile south of downtown Grand Rapids. Much of Plaster Creek’s original floodplain, like the rest of its watershed, has been drastically altered and degraded over time due to the development of residential neighborhoods, commercial properties, agriculture, and industrial zones. Floodplains house unique assemblages of Michigan’s native biodiversity and sustain stream and watershed health, warranting their preservation and restoration. Over several seasons, Calvin University Herbarium’s Emma Cole Grand Rapids Flora Project inventoried seven remnant floodplain sites along Plaster Creek from near its source in Gaines Township to downstream areas within the City of Grand Rapids. A total of 438 species of vascular plants were documented for the combined seven floodplains, of which 341 (77.9%) are native. Floristic Quality Assessments were calculated for each of the sites with values ranging from a Total Floristic Quality Index (FQI) of 30.4 (Total Mean C = 2.8) at the smallest site with only 93 native species (78.7%), to a Total FQI of 52.7 (Total Mean C = 3.6) at the Ken-O-Sha Park floodplain, with 176 (82.2%) native species. The Stanaback Park floodplain had a similar number of native species, 174 (80.9%), and a Total FQI of 48.4 (Total Mean C = 3.3). In order to make comparisons with floristic information compiled by Emma Cole in the 1890s, a Floristic Quality Assessment was calculated based on 65 species (98.5% native) collected and reported by Cole (1901) as occurring along Plaster Creek. The Total FQI of Cole’s list was 48.4 (Total Mean C = 6.0), and 27 of her species have a high level of fidelity to a narrow range of ecological conditions, five of which today hold Special Concern, Threatened, or Endangered status in Michigan. By comparing our inventory findings with the floristic information gathered by Cole, this study highlights changes that have taken place in the Plaster Creek floodplain over the past 120+ years, describes the present-day condition of Plaster Creek’s floodplains, and can be used to inform future ecological restoration efforts along this and other local creeks.
Des prêts-à-écrire au service de l’écriture et de la créativité des élèves de 8 à 11 ans
Authors: Sardier Anne , Roubaud Marie-Noëlle
Published: October 2023

Nous proposons une analyse de 180 textes narratifs, du CE2 au CM2 (8-11 ans), de différentes classes et différents milieux. Il a été demandé aux élèves de produire un récit dont le début et la fin étaient donnés. Notre intérêt s’est porté sur les mots de la narration utilisés par les élèves. Nos analyses révèlent, premièrement, qu’une tension s’opère, lors de la production écrite, entre le recours à sa langue (la langue de tous les jours) et le recours à une langue plus élaborée. Deuxièmement, nous constatons que les élèves puisent des éléments lexicaux dans des scénarios de leur propre vie (en lien avec le sujet de production), tout en les combinant avec leurs connaissances linguistiques. Ils recourent à des segments plus élaborés issus de leur mémoire des textes lus ou entendus. Cette combinaison provoque soit des réussites, soit des distorsions de diverses natures : recherches lexicales ou télescopages entre différentes constructions disponibles en langue.Notre étude montre la variété des constructions que les élèves sont capables de mobiliser pour répondre à la situation d’écriture. Les choix des élèves, qui ne sont pas effectués au hasard, sont révélateurs de leur créativité.
Feasibility Study on Alternative Sensors for Acoustic Emission Damage Detection in Composite Structures
Authors: Ghadarah Noor , Ayre David , Hurley Jim
Published: October 2023

Polyvinylidene Fluoride (PVDF) and Lead Zirconate Titanate (PZT) thin-film sensors can be used to detect acoustic emissions, and their low thickness (28µm PVDF sensors available) allow them to be embedded (positioned within a laminate). However, the characteristics and sensitivity of these sensors within composite structures require further study. The attenuation curves of PZT, silver ink metallised PVDF and gold metallised PVDF sensors, when mounted using a variety of couplants such as ultrasonic gel, resin, silicone adhesive and thin double-sided adhesive tape, have been generated. Investigations also include positioning the sensor within the laminate, as opposed to on the surface, and monitoring the performance changes with respect to the through-thickness position. The sensors coupled using resin have shown to generally have the highest amplitude, with the highest being the PZT yielding 88 dB at 5cm. Initial comparisons of signal detection by the sensors with respect to fibre orientation have shown that signal travelling along the fibres generally has higher amplitude when compared to at 45o. This research is the first step toward identifying the preferred sensor type and position within the structure for damage detection.
Validation of Variable Rotor Speed Trim Using Computational Fluid Dynamics
Authors: Thai Austin D. , Roget Beatrice , Sitaraman Jayanarayanan , Zawodny Nikolas S. , Grace Sheryl M.
Published: October 2023

A multirotor trim algorithm is developed and validated using the HPCMP CREATETM -AV Helios rotorcraft analysis and simulation framework. Validation data were sourced from experiments in which a quadrotor with xed-pitch rotors was trimmed for steady hover and forward flight
in the NASA Langley Low-Speed Aeroacoustic Wind Tunnel. For each ight condition, the aircraft attitudes were fixed so that the only control variables were the rotation rates of the four rotors, which were varied until the residual loads were minimal. The resultant trim states were rst replicated
in the computational framework to verify the aerodynamic solver. Then, the trim algorithm was validated in Helios by constraining the aircraft attitudes and searching for the rotor speeds that minimized the residual loads. The analysis demonstrated excellent agreement between the predicted
and measured trim states. Finally, free-flight trim cases were simulated to quantify the effect of the trim constraints and verify the experimentally trimmed ight conditions. The predicted free-flight trim state showed reasonable agreement to the constrained case, with negligible change in
the residual loads, indicating trim was achieved in both the experiments and the simulations.
Long-term Rituximab Therapy in Adult Patients with Idiopathic Nephrotic Syndrome
Authors: El-Reshaid Kamel , Al-Bader Shaikha , Madda John Patrick
Published: October 2023

Patients with refractory idiopathic nephrotic syndrome (INS) are at risk of infections, renal failure, and the inherent side effects of immunosuppressive therapy. In the present study, we investigated the efficacy of yearly rituximab therapy in adult patients with this syndrome over 5–10 years. In the minimal change disease group, 14 of the 15 patients had complete remission (CR) and one had partial remission (PR). Of those who achieved CR, eight patients did not require rituximab 4 years later. The patient with PR was treated in the same way as those with focal segmental glomerulosclerosis (FSGS) group and remained stable by the end of the study. In the FSGS group, rituximab therapy resulted in the amelioration of INS in nine patients, although two were non-responders (NR) and developed end-stage renal disease (ESRD). In the membranous glomerulopathy group, 36 patients had CR but two were NR and developed ESRD. Twenty (55%) of those did not require treatment after 4 years, whereas the rest maintained CR with yearly rituximab. Nine women received rituximab after the third month of pregnancy without significant adverse effects on the fetus or subsequent conception. In conclusion, rituximab is a safe, practical, and effective long-term therapy for adult patients in these three groups of INS.
Prevalence of Non-adherence to Prescribed Medications among Hemodialysis Patients in Makkah City
Authors: Alzahrani Ali Mohammed A.
Published: October 2023

Patients with end-stage kidney disease (ESKD) are required to take multiple medications. Adherence to a complex regimen of medications is challenging and might lead to non-adherence. This study aimed to assess nonadherence to prescribed medications among patients with ESKD in Makkah City and determine the factors associated with a such behavior. A cross-sectional study was conducted at three governmental hospitals in Makkah City, Saudi Arabia. Descriptive statistics were performed to characterize participants, and a multivariable logistic regression analysis was used to determine factors associated with nonadherence to prescribed medications among patients with ESKD. In total, 358 patients have submitted completed surveys and were included in this study. A considerable number (45.25%) of participating patients were found to be nonadherent to prescribed medications. The factors: age, belief that taking medications as scheduled is important, adherence to dialysis sessions, and the number of comorbid diseases had significant and negative associations with nonadherence to prescribed medications. On the other hand, the factors: forgetfulness and having depression were significantly and positively associated with non-adherence to prescribed medications. Non-adherence to medications among patients on hemodialysis is a significant issue that leads to life-threatening complications. The factors identified as being significantly associated with nonadherence should be considered in designing future interventions to improve adherence to medications.