bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Kinetics and Mechanism of the One-Pot Formation of 3,4,5-Substituted Furan-2(5H)-Ones in the Presence of Lactic Acid: Effect of Different Substituents
Authors: Asheri Osman , Habibi-Khorassani Sayyed Mostafa , Shahraki Mehdi
Published: October 2018

The kinetics of the reaction between para-substituted anilines and dimethyl acetylenedicarboxylate (DMAD) with derivatives of benzaldehyde for the one-pot formation of 3,4,5-substituted furan-2(5 H)-ones in the presence of lactic acid as a catalyst have been studied spectrophotometrically at different temperatures. A mechanism involving four steps was proposed for the reactions, all of which followed second-order kinetics. The partial orders with respect to substituted aniline and DMAD were one and one and the reactions revealed zero-order kinetics for benzaldehyde and its derivatives. Changing of substituents on benzaldehyde left rates of reaction unaffected. However, various substituents on aniline showed that para electron-withdrawing groups decreased the rate of reaction. According to investigation of an isokinetic relationship, a common mechanism exists for all studied substituents and a general mechanism can be formulated. Kinetic values ( k and Ea) and associated activation parameters (Δ G‡, Δ S‡ and Δ H‡) of the reactions were determined.
Counterfactual Objectives of University Education
Authors: Boychenko Natalia
Published: October 2018

Subject of counterfactuality is essential for ethics and philosophy of education, but despite this fact, still has not found a proper philosophical reflection in domestic science - rather philosophical texts meet philologists, in linguistics counterfactuality associated primarily with Plusquamperfekt, long-past time that also  used increasingly to describe unreality of the situation and actions in the present and future time. Unreality of moral standards is relative – they are unreal only to the extent that they can not be implemented without any special effort – very this effort gives them the power and reality even more than ones having “realistic”, positivist standards. This temporal aspect recedes into the background, and to the foreground opposition steps – of traditionalism and modernity desire to change, to improve the world, ourselves, the others. With Plusquamperfekt one can identify different models as models of counterfactual subjective distancing from the flow of events through distancing from: inadequate (partially adequate) senses; inadequate (excessive, reduced or even false) emotional perception; inadequate action results intentions; values discrepancy of the object of perception. Values are always opposed to the counter-value or irrelevant value. Then and there appears actually a philosophical interest to the concept of counterfactuality that can be called a priori selected context. Thus, taking a counterfactual position, we choose a semantic context of our behavior – sensual, emotional, instrumentally rational, value, etc – and give it absolute value relatively to all other possible contexts – within our strategy of certain behavior. Not omly academic values should be considered after the model of counterfactuality –also other values of university education should be. And the same academic values should be deprived of a significant part of their idealization – a value that acquire a real education is regulatory, not absolute. Academic values become variability in the structure of value orientations of different university communities. If the version of each academic values considered as self-sufficient in its counterfactuality subsystem of values, then one gets pluralistic academic values picture in which different versions of their interpretation partially complementary, but may partially be contradict one another. And counterfactual academic values may be supplemented by other counterfactual university values, such as institutional. Counterfactuality may have different directions and different levels of modalities – both for different communities within the university and for different universities.
Registration of NM 970123, NM 990813, and NM W1218 Germplasm Lines of Upland Cotton
Authors: Zhang Jinfa , Cantrell Roy G. , Hughs Sidney E. , Jones Don C.
Published: October 2018

Three Acala cotton (Gossypium hirsutum L.) germplasm lines, designated as NM 970123 (Reg. No. GP‐1045, PI 688432) and NM 990813 (Reg. No. GP‐1046, PI 678373), both with the normal leaf, and NM W1218 (Reg. No. GP‐1047, PI 678372) with the okra leaf, were developed through pedigree selections by New Mexico State University to provide parental lines with improved yield potentials, lint percentage, or fiber quality. NM 970123 was derived from the hybridization of ‘Acala Prema’ by W5250, NM 990813 was derived from the cross of 87D3‐24/‘Acala 1517‐95’, and NM W1218 was derived from the hybridization of B4222 by H1014. The three lines were evaluated in four to eight replicated field tests in Las Cruces, NM. Compared with ‘Acala 1517‐99’, NM 970123 had consistently higher lint percentage (by 7.5%), with higher lint yield (by 6.3%); NM 990813 improved lint yield by 14.1%; and NM W1218 with the okra leaf outyielded the check by 5.9%. When evaluated in the Western Regional Variety Tests in 2001 to 2004, NM 970123 displayed significantly higher fiber strength and higher yarn tenacity, and it also had higher seed N content but significantly lower seed oil content.
Registration of the Barley Transposon‐Tagged Population II: Sixty‐One Lines Each Characterized for Ds Insertion Sites
Authors: Bregitzer Phil , Brown Ryan H. , Dahleen Lynn S. , Singh Jaswinder , Cooper Laurel D. , Hayes Patrick M. , Lemaux Peggy G.
Published: October 2018

The USDA–ARS has developed and released a transposon‐tagging barley (Hordeum vulgare L.) population comprising 61 lines: TNPs 1, 3, 6, 11, 13, 18, 19, 22, 24, 26–35, 32B, 39–41, 48, 52, 53, 66–69, 71, 74, 79–83, 90, 92–94, 99, 100, 103, 112, 115, 116A, 116B, 117–120, 125, 130, 132, 141, 142, 144, 230, 231, and 234 (Reg. Nos. GS‐83–GS‐143; PIs 687803–687863). Each line is homozygous for a single modified Ds element encoding bar (Ds‐bar) insertion at a different genomic location, except for TNP 120, which has two insertions. The ∼3.6 kb Ds‐bar element is a modified maize (Zea mays L.) Dissociation (Ds) element containing a bar expression cassette. Two of lines (TNP 32B and TNP 48) derive from primary Ds (PDS) transpositions resulting from biolistic co‐introduction of Ds‐bar and maize Ac transposase (AcT) into ‘Golden Promise’. The rest contain either secondary or tertiary transpositions generated by remobilizing Ds‐bar via hybridization of AcT‐expressing Golden Promise plants with, respectively, PDS lines containing primary transpositions or TNP lines containing secondary transpositions. Each line was characterized for the 5′ and/or 3′ sequences flanking the Ds‐bar insertion. Insertions that interrupt native genes or regulatory elements likely will alter or abolish their function, and these lines are expected to be useful for the study of the biological roles of such genes or regulatory sequences. Most of these lines can also be used as parents for the creation of additional lines with novel transpositions of Ds‐bar.
Do RATs save lives? A retrospective analysis of out-of-hospital cardiac arrest in an English Ambulance Service
Authors: Pilbery Richard , Teare M. Dawn
Published: October 2018

Study aim
This study aims to determine the impact of the red arrest teams (RATs) on survival to 30 days and return of spontaneous circulation (ROSC) at hospital.
Methods
A retrospective cohort study analysing routinely collected data was undertaken. All adult (≥18 years) OHCAs entered onto the YAS computer aided dispatch (CAD) system between the 1st October, 2015 and 30th September, 2017 were included if the patient was resuscitated, and the cause of the arrest was considered to be medical in origin. Multivariable logistic regression models were created to enable adjustment for common predictors of survival and ROSC.
Results
During the 2-year data collection period, 15,151 cardiac arrests that were attended by Yorkshire Ambulance Service. After removing ineligible cases, 5,868 cardiac arrests remained. RATs attended 2,000/5,868 (34.1%) incidents, with each RAT attending a median of 13 cardiac arrests (IQR 7–23, minimum 1, maximum 78).

The adjusted odds ratios suggest that a RAT on scene is associated with a slight increase in the odds of survival to 30 days (OR 1.01, 95%CI 0.74–1.38) and odds of ROSC on arrival at hospital (OR 1.13, 95%CI 0.99–1.29), compared to the odds of not having a RAT present, although neither results are statistically significant.
Conclusion
The presence of a RAT paramedic was associated with a small increase in survival to 30 days and ROSC on arrival at hospital, although neither were statistically significant. Larger prospective studies are required to determine the effect of roles such as RAT on outcomes from OHCA
Ungelöste Probleme einer wirtschaftspolitischen Alternative in Frankreich
Authors: Leithäuser Gerhard
Published: October 2018

Ungelöste Probleme einer wirtschaftspolitischen Alternative in Frankreich
,,Wo die Macht aufüört, entsteht die Hoffnung"
Authors: Bieling Thomas
Published: October 2018

Die zweite italienische Studentenbewegung zwischen sozialer Emanzipation und politischer Regression*
Zur Kritik der Überakkumulationstheorie von Beckenbach und Krätke
Authors: Mattick Paul
Published: October 2018

Zur Kritik der Überakkumulationstheorie von Beckenbach und Krätke
Treatment of Vertically Unstable Pelvic Ring Injuries in Patients with Complicated Pelvic Trauma
Authors: Ushakov S. A. , Lukin S. Yu. , Nikol’Skiy A. V.
Published: October 2018

The purpose of the work was to improve the treatment results for patients with complicated pelvic injury using differentiated application of transosseous and internal osteosynthesis. Retrospective analysis of treatment results is presented for 52 patients with vertically unstable pelvic ring injuries and concomitant abdominal injuries. Clinical cases demonstrate the variants of clinical decision depending on the type of injury, degree of pelvic ring instability, pattern of concomitant abdominal injuries. Protocol of patient management in such injuries is suggested.
Temporary Noninvasive Pelvic Stabilization
Authors: Samokhvalov I. M. , Borisov M. B. , Denisenko V. V. , Grebnev A. R. , Ganin E. V.
Published: October 2018

Pelvic ring stabilization is the basic emergency care measure in unstable pelvic injuries. The purpose of the work was to determine the efficacy of pelvic bandage in patients with unstable pelvic fractures and persistent intrapelvic hemorrhage. Thirty seven patients were divided into 2 groups. In study group (n=19) primary pelvic stabilization was performed using extempore pelvic bandage; in patients from control group (n=18) external fixation devices were applied. Duration of pelvic fixation procedure, hemodynamics and quality of reposition were assessed. Duration of pelvic bandage application was significantly lower than that required for pelvic external fixation - 2.4±0.8 min versus 29±3.2 min. That advantage enabled to use the bandage before the diagnosis was completed and other injuries were eliminated - in 6.0±2.1 min after patient’s admission while the time before the application of external fixation device made up 86.0±5.6 min ( p < 0.001). Application of pelvic bandage enabled to stabilize blood pressure in the course diagnostic and treatment measures. In some cases pelvic roentgenography revealed excessive internal rotation when bandage was applied. So, application of pelvic bandage is a simple, effective, rapid method for temporary pelvic fixation.
Peculiarities of Bone Tissue Regeneration at Application of Osteoplastic Material in Experimental Model of Purulent Bone Wound
Authors: Bugrov S. N. , Mitrofanov V. N. , Aleinik D. Ya. , Kulakova K. V. , Zhivtsov O. P. , Lekishvili M. V.
Published: October 2018

Results of study of new osteoplastic material conditionally named «Kombas» were presented. That material consisted of nondemineralized animal collagen in a form of chips impregnated by vascular endothelium growth factor. The first step of experiment included in vitro study of the material was for cytotoxicity in diploid fibroblast cultures of 4-6 passages. At the second step purulent bone wounds were modelled in 36 Chinchilla rabbits. After debridement bone defect in the study group of animals (n=18) was filled with study material, in control group (n=18) the defect was not filled. Radiologic (X-ray, CT) and morphologic examination were performed at terms 1, 2 and 3 months. For objectification of the achieved data integral indices were proposed. Index of bone defect restoration in study group was 70% higher in 1 month, 47 % - in 2 months and 24% - in 3 months, as compared to the control group. In control group the index which characterized the completion of reparative processes exceeded that index in study group by 42% in 2 months and by 54% in 3 month of observation. Study results showed that elaborated material was not cytotoxic, possessed plasticity, marked osteoinductive and osteoconductive properties, as well as an ability to substitute bone tissue defects under conditions of purulent bone cavity in animal experiment.
Applied Anatomy of Median and Ulnar Nerve Branches in Operations for Forearm Muscles Neurotization
Authors: Golubev I. O. , Zhuravlyov S. A.
Published: October 2018

To determine the potentialities of median nerve motor branches neurotization by the ulnar nerve and vice versa the anatomy of muscular branches of median and ulnar nerves in the forearm was studied in detail. Study was performed on 20 upper extremities from 10 adult cadavers. The number of branches, their length and precise place of divergence from the main trunk were assessed. It was stated that topographic anatomy of muscular branches of the median and ulnar nerves in the forearm was quite invariable. For neuratization from the median nerve the longest branches that passed to pronator teres muscles and superficial flexor muscle of fingers can be used; from the ulnar nerve - long branch to the ulnar flexor muscle of wrist.
Experience in Transosseous Arthroscopic Restoration of Shoulder Rotator Cuff
Authors: Lomtatidze E. Sh. , Kubashev A. A. , Belyak E. A. , Lazko F. L. , Prizov A. P.
Published: October 2018

Results of arthroscopic treatment for 10 patients (10 shoulder joints) with rotator cuff rupture using transosseous suture are presented. Mean age of patients made up 49 (38-63) years. In 2 cases the size of defect was under 1 cm, in 6 cases - 1-3 cm, in 2 cases - 3-5 cm. Mean score by UCLA scale was 13 (8-14) preoperatively and 26 (24-28) in 3 months after intervention. Advantages of the described technique include rapidity of performance, low price and provision of anatomic restoration of injured structures.
Intramedullary Osteosynthesis by Fixion System at Treatment of Long Bones Diaphyseal Fractures
Authors: Yamkovoi A. D. , Zorya V. I.
Published: October 2018

Treatment results for 61 patients with diaphyseal fractures of long bones of the extremities are presented. Fractures of the humerus were diagnosed in18 (29.5%) patients, femur - in 22 (36.1%) and tibia - in 21 (34.4%) patients. In most cases fractures of A1, A2, A3 and B1 were observed. For osteosynthesis blocking and non-blocking Fixion intramedullary nails were used. Long-term results (1 - 1.5 years) were analyzed for 42 patients and showed excellent and good results in 93% of patients. Nonunion and deformity was observed in 7% of observations. The advantages of the technique included low traumatization, short duration of surgical intervention, minimum (up to 200 ml) blood loss.
Outcomes of Surgical Treatment of Infectious Complications after Large Joints Arthroplasty
Authors: Norkin I. A. , Shpinyak S. P. , Girkalo M. V. , Barabash A. P.
Published: October 2018

Surgical outcomes were analyzed for 108 patients with infectious complications developed at different terms after large joints arthroplasty. When complications develop in the early postoperative period than independently of the process depth and in stable implant components radical surgical debridement of the inflammation focus is indicated. In the rest of cases the removal of all implant components with subsequent either joint arthrodesis or revision arthroplasty using spacers of different modifications should be performed. We consider spacer application to be a method of choice as it enables to preserve extremity function and to perform revision arthroplasty in future.
Intraneural Ganglion as the Cause of Compression-Ischemic Lesion of Peroneal Nerve in Children
Authors: Merkulov V. N. , Imyarov Sh. D. , Dorokhin A. I.
Published: October 2018

Two clinical cases of peroneal nerve lesion (patients 13 and 16 years) resulted from intraneural ganglion are presented. It is shown that only radical surgical intervention including resection of tibiofibular junction, removal of communicating canal and nerve decompression using cyst dissection (Spinner technique) could prevent ganglion relapse. In first patient completely lost peroneal nerve function was restored by musculotendinous transposition.
Osteosynthesis of Distal Humeral Metaepiphyseal Fractures Via Posterior Approach with Olecranon Preservation
Authors: Kalantyrskaya V. A. , Golubev I. O.
Published: October 2018

Eighteen patients with distal humeral metaepiphyseal fractures were operated on during the period from 2010 to 2013. Mean age of patients made up 43.1±8.4 (22-72) years, term after injury - 4.6±1.9 (2-11) days. According to AO classification C1 fractures were diagnosed in 13, C2 - in 3, C3 - in 2 patients. In all patients distal humeral metaepiphyseal osteosynthesis with two plates placed at 90° to each other was performed. Surgical intervention was performed without olecranon osteotomy and triceps tendon was kept intact. In 12 (66.7%) cases longitudinal dissection of the triceps in its middle third was performed. Residual intraarticular displacement averaged 0.2±0.03 mm. Long term results were assessed in 10 patients at an average 12 months after operation. Mean score by subjective and objective scales made up 4.3±0.3 and 4.2±0.3 points, respectively. Main advantages of the applied osteosynthesis technique were preservation of forearm extensor muscles integrity; absence of additional fixatives in olecranon zone; absence of the necessity to perform additional intervention to remove fixatives from the olecranon.
Experience in Treatment of Total Hand Syndactyly in a Child with Apert Syndrome
Authors: Kozhevnikov O. V. , Ivanov A. V. , Gavrilova Yu. V.
Published: October 2018

Experience in surgical treatment of total hand syndactyly in a child with Apert syndrome is presented. Surgical technique that includes the application of МЦТ-01 apparatus, distraction period and interdigital space formation with local tissues, i.e. interchanging triangular or oblique-trapeziform flaps is described. Within 18 months interdigital spaces between II and III, III and IV, IV and V fingers were formed in turn. Besides marked cosmetic effect comparatively good functional result was achieved.
Treatment of Type 1 Complex Regional Pain Syndrome in 14 Years Old Child
Authors: Merkulov V. N. , Dorokhin A. I. , Krupatkin A. I. , Merkulov M. V. , Avakova M. A.
Published: October 2018

Case report on 14 years old girl with type 1 complex regional pain syndrome (CRPS) is presented. At first admission in 5.5 months after right hand injury and development of type 1 CRPS, paravasal sympathectomy on the right upper extremity was performed. Complete elimination of pain syndrome and restoration of the extremity function was achieved. Five and a half months after discharge the left foot and in 3 weeks later the right hand were injured. In both cases injuries were accompanied by pronounced CRPS clinical picture. At second admission in 6 weeks after foot injury interventional treatment with placement of catheters next to nerve trunks and bolus administration of antibiotics was performed for 1 week and enabled to achieve remission of the disease. It was noted that not only hypersymphaticotony but also psychological status of a patient were important for the disease development.
Hip Reconstruction with Demineralized Allografts in Revision Arthroplasty
Authors: Chekanov A. S. , Voloshin V. P. , Lekishvili M. V. , Ochkurenko A. A. , Martynenko D. V.
Published: October 2018

Long term results of revision arthroplasty with hip joint reconstruction using demineralized allograft based on cranial vault flat bones are presented. Since 2005 nine patients (14 substitutions) aged from 46 to 67 years were operated on. Control of implanted material remodeling was performed in 12 months after surgery and then annually up to 8 years. No one case of implanted material suppuration was observed. Roentgenologic control showed relatively early remodeling of allografts in 1.5-2 years after intervention. Remodeling process was characterized by the increase of roentgenologic density in plasty site. Positive results were achieved 8 patients (13 substitutions) that made up 93%.
Russian Experience in Rational Thromboprophylaxis in Traumatology and Orthopaedics
Authors: Firsov S. A. , Levshin A. G. , Matveev R. P.
Published: October 2018

Analysis of safety and efficacy of the currently marked peroral anticoagulants was performed in long term follow up of patients after large joints arthroplasty. Total number of 5025 patients after total knee arthroplasty and 5216 patients after total hip arthroplasty were examined. All patients were divided into groups depending on the prescribed anticoagulant. The course of anticoagulant therapy made up 35 days and 6 weeks after surgery, respectively. US examination of the veins of lower extremities was performed to all patients prior to and on day 5 after operation. In patients on Dabigatran the rate of clinically significant deep vein thrombosis was lower than in group of patients on Rivaroxaban and Apixaban, but the rate of postoperative hematomas in lust two groops was higher.
Hip-spineSyndrome and its Significance in Complex Treatment of Patients with Combination of Degenerative Dystrophic Pathology of Hip Joint and Spine (literature review)
Authors: Kudyashev A. L. , Khominets V. V. , Shapovalov V. M. , Miroevskiy F. V.
Published: October 2018

In foreign literature a combination of degenerative dystrophic changes in hip joint and lumbosacral spine accompanied by their mutual aggravation is referred to as hip-spine (coxo-vertebral)syndrome. This pathologic condition is characterized by the variety of clinical forms, morphologic manifestations and degrees of the pathologic process intensity that predetermines objective difficulties in diagnosis and treatment of such patients. The main role in the process of degenerative dystrophic changed development is played by biomechanical factors including vertebropelvic relationships. In the overwhelming majority of patients with coxarthrosis the low back pain is caused by the changes in spinal motion segments that progress with the development of hip deforming arthrosis resulting in biomechanical disorders. All that leads to objective difficulties in diagnosis of this complex pathology and patients’ dissatisfaction with the hip arthroplasty results.
Revision Hip Arthroplasty: Epidemiology, Causes, Risk Factors (foreign literature review)
Authors: Kaminskiy A. V. , Marchenkova L. O. , Pozdnyakov A. V.
Published: October 2018

Publications related to revision hip arthroplasty were analyzed. Data of National Registers from different countries were presented, problems of epidemiology and prognostication of need in revision arthroplasty were highlighted, the causes (demographic, clinical, surgical, rehabilitation) and the most significant risk factors that conditioned the failure of primary hip arthroplasty were described.
Peroneal Tendon Dislocations
Authors: Koryshkov N. A. , Khodjiev A. S. , Dzyuba A. M. , Platonov S. M. , Larionov S. V. , Shcherbakov A. O.
Published: October 2018

Clinical observation of patients with posttraumatic deforming arthrosis of subtalar joint resulted from calcaneus fracture and preoperatively diagnosed closed old dislocation of left foot peroneal tendons is presented. The necessity of thorough examination of patients with hindfoot injuries and expediency of surgical interventions not only on the bony but also on the soft tissue structures is substantiated. Such interventions will provide for the restoration of the normal anatomical position of peroneal tendons.
Surgical Treatment of Juvenile Femoral Head Epiphysiolysis in Children
Authors: Barsukov D. B. , Krasnov A. I. , Kamosko M. M. , Baskov V. E. , Pozdnikin I. Yu. , Aleksandrenko I. P.
Published: October 2018

To optimize the anatomical and functional surgical treatment results in patients with early (I-II) stages of juvenile femoral head epiphysiolysis both pre- and postoperative data of clinical, x-ray and magnetic-resonance examinations were analyzed for 120 patients aged 11 - 15 years. Maximum follow up period after surgical interventions, i.e. femoral head epiphysiodesis (n=60) and femoral head epiphysis fixation (n=60) made up 23 and 3 years, respectively. It was shown that surgical intervention for the fixation of femoral head epiphysis ensured reliable stability of the epiphysis preventing the latter from displacement development and progression, and did not exert significant influence upon either femoral neck and head endochondral growth or the length of the upper extremity.
Differential Diagnosis of Large Joints Chronical Synovitis
Authors: Zar V. V. , Shatokhina S. N.
Published: October 2018

To determine the genesis of large joint chronical synovitis the morphologic picture (facia) of synovial exudate was studied in 23 patients using the method of cuneate dehydration of biological liquid. Cytologic investigation showed leukocytosis with prevalence of neutrophils in all patients. All patients were divided into two groups. First group included 8 patients in whom septic pattern of inflammation was confirmed by the results of synovial fluid culture inoculation, second group - 15 patients with negative bacteriologic study results. The obtained data enabled to describe two types of synovial fluid facia that allowed differentiating septic pattern of inflammation from the reactive one.
Comparative Study of the Adhesive Component of Friction in Hip Endoprostheses
Authors: Minasov B. Sh. , Yakupov R. R. , Shuster L. Sh. , Chertovskikh S. V. , Emaev I. I. , Filimonov G. N. , Korshunov A. A. , Khairov T. E.
Published: October 2018

Kinematic unit friction pairs of human hip endoprosthesis and rabbit hips with induced osteoarthrosis were studied under conditions of either dry or biological medium friction. Deterioration of tribologic characteristics in destructive dystrophic lesions of joints is the key component of joint kinematic properties decompensation. Experimental animal model of osteoarthrosis showed negative influence of dystrophic changes upon the hip joint adhesive characteristics. Study of the adhesive component of friction coefficient in different tribologic pairs of endoprostheses detected that friction characteristics of the studied tribologic pairs depended upon the magnitude of external load and strength of the kinematic unit.
Use of PlateletRich Autoplasma in Complex Therapy of Knee Osteoarthrosis
Authors: Gorbatenko A. I. , Kostyanaya N. O.
Published: October 2018

Efficacy of platelet-rich autoplasma (PRA) in treatment of osteoarthrosis was evaluated. Prospective study included 120 patients (83 females, 37 males, mean age 52.8±4.5 years) with clinical and roentgenologic diagnosis of II-IV stage osteoarthrosis by Kellgren-Lawrence classification. The patients from the main group (n=60) were on courses of PRA intraarticular injections (3 injections with 1-2 weeks interval). In the control group the patients received nonsteroidal anti-inflammatory drugs (NSAIDs) and periodically injections of glucocorticoids when indicated. Results were assessed by the verbal efficacy scale, Lequesne index and the pain visual analog scale. Follow up period made up 6 months. Use of PRA enabled to eliminate pain syndrome and improve knee joint function without adverse effects. In 6 months the number of patients who noted the efficacy of treatment was 31% higher in the main group than in the control one. The obtained results allow recommending PRA use for knee osteoarthrosis treatment as an alternative to NSAIDs especially in contraindications to the latter.
Arthroscopy in Treatment of Knee Arthroplasty Complications
Authors: Alabut A. V. , Sikilinda V. D. , Kubasov D. O.
Published: October 2018

Results of the operated joint arthroscopy were presented for 16 patients with complications after knee arthroplasty. The reasons for arthroscopic intervention were: implant instability - 1 case, breaking of implant hinge - 1 case, arthrofibrosis - 2 cases, recurrent hemarthrosis with synovial membrane vessels malformation - 2 cases, reactive aseptic necrosis - 4 cases and resistant medial pain syndrome resulting from neuropathy of the infrapatellar branch of subcutaneous femoral nerve - 6 cases. Arthroscopy after knee arthroplasty enables with high accuracy to diagnose knee joint pathology, to avoid revision arthrotomy, to minimize intraoperative trauma, to improve functional results and patient’s quality of life as well as to reduce the cost of treatment.
Efficacy and Safety of Two-Level Brachial Plexus Block at Locking Intramedullary Shoulder Osteosynthesis
Authors: Dubinenkov V. B. , Lyuboshevskiy P. A. , Larionov S. V. , Koryshkov N. A. , Shushpanova E. V.
Published: October 2018

Results of the comparative study of the efficacy and safety of one- and two-level brachial plexus block (BPB) at locking intramedullary shoulder osteosynthesis are presented. Fifty five patients (mean age 43.4±3.2 years) with humeral diaphysis fracture were operated on. In the main group of patients (n=28) two-level BPB was performed: interscalene block was combined with supraclavicular brachial plexus block and superficial brachial plexus block (SBPB). In control group (n=27) one-level interscalene and superficial BPB and SBPB were performed. Severity of pain syndrome was assessed by visual analog scale. It was shown that two-level BPB ensured better anesthetic, postoperative analgesic effect and higher percent of successful regional anesthesias as well as decreased the requirement in narcotic analgesics on the first postoperative day. The number of complications did not differ significantly between the groups.
Spontaneous Resorption of Intervertebral Disc Herniations
Authors: Kuleshov A. A. , Krupatkin A. I. , Murav’Yova N. V.
Published: October 2018

The data on the possibility of intervertebral disc herniation regress at terms from 3 to 12 months are presented. Immune response of the organism and the factor of peripheral fibrous ring neovascularization play an important role in the process of disc herniation resorption. Transligamentous and sequesteredherniations are resorbed better than the subligamentous ones. To intensify the intervertebral disc herniation resorption it is necessary to activate microcirculation of the injured spinal motion segment.
Effect of Postoperative Wound Drainage on the Frequency of Red Blood Cells Transfusion after Primary Hip Arthroplasty
Authors: Grechanyuk N. D. , Zver’Kov A. V. , Ovsyankin A. V. , Zhiburt E. B.
Published: October 2018

The effect of postoperative wound drainage on the frequency of red blood cells transfusion after primary hip arthroplasty was assessed. Prospective comparative study included 632 patients. The patients were divided into 2 groups depending on whether the postoperative drainage was performed (1st group) or not (2nd group). Duration of surgery, volume of intraoperative blood loss, the level of hemoglobin before surgery and during the first postoperative day, frequency and volume of red blood cells transfusion during the whole period of hospital treatment was evaluated. In group 1 donor red blood cells transfusion was required in 1.3%, in group 2 - in 0.8% of cases (p>0.05). No data on the effect of postoperative wound drainage upon the frequency of red blood cells transfusion after primary hip arthroplasty was obtained.
History, Present and Future of Knee Arthroplasty
Authors: Prokhorenko V. M. , Mamedov A. A. , Baitov V. S.
Published: October 2018

The review covers different aspects of knee joint arthroplasty. With improvement of arthroplasty techniques the joint implants are constantly perfected: the more strong alloys with high biocompatibility are used for their production, design is developed using mathematical models, endoprosthesis friction node are subjected to long-term bench testing. All these innovations are directed at the improvement of implant quality, increase of their survival time, minimization of toxic effect on the patient’s organism. Taking into account all advantages and disadvantages of the available joint implants with different design and various friction pairs being detected from literature data and by our experience it was concluded that elaboration of joint implant with increased wear resistance is required.
Use of Modified Arthroscopic Ankle Joint Stabilization for the Treatment of Chronic Lateral Instability
Authors: Matsakyan A. M. , Kesyan G. A. , Ochkurenko A. A. , Butaev B. G. , Shirmazanyan A. G. , Protsko V. G.
Published: October 2018

Comparative analysis of the results of anatomic restoration of capsuloligamentous system in chronic lateral ankle instability using low invasive arthroscopic techniques was performed.

Patients and methods.Forty seven patients (17 - 60 years old) with chronic lateral ankle instability were operated on. In 20 patients a standard “ArthroBrostrum” technique with a use of 2-3 biocomposite fixatives and in 27 patients - the modified arthroscopic intervention with use of 1 titanium anchor was performed. Treatment efficacy was evaluated by AOFAS score.

Results. One year after surgery treatment results were followed up in 39 patients: excellent results were achieved in 7 (36.84%), good - in 7 (36.84%), satisfactory - in 3 (15.79%) and poor - in 2 patients after standard technique and in 8 (40.00%), 7 (35.00%), 4 (20.00%) and 1 (5.00%) after modified method, respectively.

Conclusion.Thus modified arthroscopic technique is in no way inferior to a standard “ArthroBrostrum” intervention having certain advantages (use of 1 versus 3 fixatives, possibility of intraoperative X-ray control, and shortening of the operation duration). So it could be recommended for the treatment of patients with lateral ankle instability.
Treatment of Benign Bone and Joint Tumors and TumorLike Diseases Using Alloplasty and Collagen Containing Material (Clinical and Experimental Study)
Authors: Zorya V. I. , Krasil’Nikov A. A. , Chemyanov I. G. , Matveev A. G.
Published: October 2018

Purpose. Improvement of surgical treatment results in patients with benign bone and joint tumors and tumor-like diseases.

Materials and methods.Evaluation of the efficacy of plastic collagen containing material for bone defect plasty was performed in 58 Chinchilla rabbits (3-4 kg). In animals from study group the bone defect was filled with collost. Histological examination of the samples was performed in 14, 30, 60 and 90 days after operation. During the period from 2007 to 2015 ninety eight patients, aged 14-75 years, with benign bone and joint tumors and tumor-like diseases were operated on. In all cases postresection defect (1-50 см_) plasty was performed by the proposed combined method that included the use of frozen allograft and collost. During subsequent follow up the potentiality of pathologic process relapse was determined as well as the dynamics of bone structure restoration, extremity function and bone anatomic shape were assessed.

Results.Pathomorphologic picture of experimental samples showed that collast accelerated the bone regenerate maturity in the place of a defect. In 1 year after surgery 74 patients (75%) showed good results - in 8 (11.2%), satisfactory - in 62 (84.1%), poor - in 3 (4.7%) cases and in 3 years after operation (57 patients) - 28 (49.1%), 28 (49.1%) and 1 (1.7%) case respectively. Examination of 56 patients (57.1%) in 5 years after intervention revealed good results in 48 (85.4%) and poor - in 8 (14.6%) cases.

Conclusion.Study results allow recommending the proposed method of plasty using the allograft and collost for the substitution of vast postresection defects in patients with benign bone and joint tumors and tumor-like diseases.
Characteristics of Pain Syndrome in Patients with Lumbosacral Discogenic Pathology in Post- OPERATIVE PERIOD
Authors: Gospod A. O. , Krupatkin A. I. , Kuleshov A. A. , Sokolova T. V.
Published: October 2018

Purpose of study. Evaluation of the pain sources and comparative analysis of chronic pain syndrome peculiarities in patients with various types of disc herniation before and after surgical intervention at lumbosacral level.

Patients and methods. The study included 80 patients (20-60 years old) with discogenic pathology at lumbosacral level. The type and size of herniation was assessed by MSU classification. Every patient went through a complex evaluation of low back pain sources, pain syndrome characteristics and personality before and on day 10 after surgery.

Results.The most common cause of pain was a musculoskeletal syndrome that was more pronounces in the older (41-60 years) group. Neither correlation between the degree of degenerative dystrophic changes and type and size of discogenic pathology, nor the relation between the disc herniation size and type and neurologic symptoms development was detected. The relation between the intensity and other characteristics of pain syndrome and type of disc herniation was not detected too. Analysis of pain syndrome characteristics and mechanisms in complex with the assessment of pain sources revealed the group of patients with high pain and emotionally affected indices before and after surgical intervention and mild vertebrogenic and other pain sources. That group made up 13% of the total number of patients; the majority of them (75%) were females (mean age 37.8±5.0 years) and in 50% of cases the herniation size and localization corresponded to type 2A. Taking into consideration a high degree of disability and other pain indices in postoperative period we do not recommend surgical intervention in this group of patients.

Conclusion.Management of patients with lumbosacral intervertebral disc herniation requires the evaluation of all pain sources and pain syndrome aspects.
Advantages and Disadvantages of Various methods for Dupuytren’s Contracture
Authors: Ulishchenko A. A. , Golubev I. O.
Published: October 2018

Current methods for Dupuytren’s contracture treatment - conservative, radical surgical, low invasive are presented. Their advantages and disadvantages are discussed. Unfortunately no one method allows to avoid relapses at various terms after treatment. In the lack of common approach to the choice of treatment tactics the low invasive techniques such as needle aponeurotomy, collagenase injections, percutaneousaponeurotomywith lipofilling (lipografting)are becoming more popular.
POTENTIALITIES OF 3D-VISUALIZATION IN PREOPERATIVE PLANNING OF PRIMARY AND REVISION TOTAL HIP ARTHROPLASTY
Authors: Sadovoy M. A. , Pavlov V. V. , Bazlov V. A. , Mamuladze T. Z. , Efimenko M. V. , Aronov A. M. , Panchenko A. A.
Published: October 2018

A variant of preoperative planning for revision interventions on a hip joint named “Method of layer by layer 3D visualization of the defect zone” is suggested. The method is realized via three consecutive steps with the ultimate aim to obtain data on the real acetabular defect geometry and bone tissue density. Using that method 9 patients (mean age 60±2 years) with pelvic bones defects were examined preoperatively. Based on the evaluation results of bone tissue condition in the defect zone the model and size of individual augment within the limits of weight bearing bone were corrected, the points of augment and acetabular component fixation were determined.
Reverse Total Shoulder Arthroplasty in Proximal Humeral Fractures
Authors: Petrosyan A. S.
Published: October 2018

Primary reverse total shoulder arthroplasty was performed in 13 patients, aged 65 – 83 years, with three- and four-part (by Neer classification) proximal humeral fractures. Rotator cuff injuries and shoulder contractures of various degrees were present in all patients. Surgical technique and postoperative rehabilitation program were described in details. Treatment results were assessed roentgenologically by Constant-Murley score in 6 months, 1, 2 and 3 years after intervention. Reverse total shoulder arthroplasty enabled to achieve good functional outcomes and considerable pain relief even in elderly patients with compound fractures and rotator cuff injuries.
ANALYSIS OF THE CONSERVATIVE TREATMENT EFFICACY IN PATIENTS WITH SUBACROMIAL IMPINGEMENT SYNDROME
Authors: Emel’yanenko M. V. , Lazko F. L. , Gazhonova V. E. , Krivoshey I. V.
Published: October 2018

Purpose:to evaluate the efficacy of the conservative treatment of patients with subacromial impingement syndrome (SIS) and supraspinatus muscle tendon (SMT) pathology using optimized clinical and beam algorithm.

Patients and methods.Complex evaluation of the conservative treatment efficacy (physiotherapeutic treatment (PHT), exercise therapy (ET), shockwave therapy (SWT)) was performed in 128 patients 67 (52.3%) men, 61 (47.7%) women with SIS. Mean age of patients was 59±8 years (24 – 82 yrs), follow up period – 9.6 ±5.6 months (maximum 18 mos). All patients underwent optimized complex clinical and beam examination. Treatment efficacy was evaluated in dynamics at terms 3, 6 and 9 months. Dynamics of pain syndrome and structural changes in STM regress was assessed depending on the type of treatment.

Results.In 3 months positive effect of conservative treatment was noted in 67 (65%), in 6 months – in 78 (77%) and in 9 months – in 84 (82%) patients. High correlation of data obtained using the elaborated pain scale for a shoulder with the visual analogue scale data at treatment monitoring (r=0,89) as well as with the monitoring US data (r=0,94) was determined. The combination of SWT+ET+PHT or SWT+PHT showed good therapeutic effect in 3 months after treatment and by 6th month excellent result was recorded in 85% of cases. Due to the long rehabilitation period in operated patients in 3 and 6 months after intervention only the satisfactory result with mean point 3.02±0.12 and 3.52±0.14 respectively was achieved.

Conclusion.In patients with SIS and SMT pathology the most effective is a combined conservative treatment with SWT+ET+PHT or SWT+PHT. However a conservative treatment efficacy is significantly influenced by the SIS stage, anatomical structure of acromeonon as well as the type of SMT structural changes.
STUDY OF RIVAROXABAN FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS AFTER LOWER EXTREMITY FRACTURES IN RUSSIAN CLINICAL PRACTICE
Authors: Belov M. V.
Published: October 2018

Thepurposeof the study was to evaluate the efficacy and safety of rivaroxaban in patients after surgical treatment for the lower extremity fractures.

Patients and methods. Retrospective multicenter study included 663 patients with femur fractures, 43 patients with complications after total hip arthroplasty (periprosthetic femur fractures, recurrent dislocation) and 10 patients with shinbone fractures. The majority (81.99%) of patients were elderly or senile. In postoperative period all patients received a standard prophylactic dose of anticoagulants. Out of them 75 (main group) – rivaroxaban (10 mg/day), 241 (control group) – other drugs (enoxaparin – 40 mg/day and dabigatran etexilate 150 or 220 mg/day). The efficacy of prophylaxis was assessed by clinical picture and Doppler ultrasound scans.

Results.Average bed day made up 9.28. During hospitalization no cases of PE were recorded. In the main and control groups the rate of deep vein thrombosis with clinical manifestations made up 1.89 and 3.31%, respectively. No cases of fatal bleeding occurred. Signs of continuous bleeding in the area of surgical intervention (soaking dressings or recurring wound hematomas) in the main group was recorded rarely (3.15%) than in the control one (8.29%).

Conclusion.Reduction of VTE rate with no increase in bleeding risk indicates the feasibility of rivaroxaban use for postoperative PE prophylaxis in patients with lower extremity fractures.
PECULIARITIES OF INTRAMEDULLARY NAILING IN TREATMENT OF EXTRAARTICULAR PROXIMAL TIBIAL FRACTURES
Authors: Semenistyi A. A. , Litvina E. A. , Fedotova A. G. , Mironov A. N.
Published: October 2018

From the biological and biochemical points of view closed blocking intramedullary osteosynthesis is an optimum technique for the treatment of extraarticular proximal tibial fractures. The disadvantage of the technique is the complexity of reposition achievement and maintenance. Great number of surgical methods and implants with different efficacy and safety has been proposed to solve these problems. The review presents the analysis of literature dedicated to different methods of reposition achievement and maintenance in intramedullary osteosynthesis of extraarticular proximal tibial fractures.
IMPROVEMENT OF WORK CLOTHES FOR EMPLOYEES THAT WORK IN LOW TEMPERATURE CONDITIONS
Authors: Gornostay O. , Stanislavchuk O.
Published: October 2018

The article deals with the ways of working conditions improvement for employees that work in the open air during the cold period of the year for a long time. Hypothermia of the body is a consequence of thermal disorder. Such disorder develops in cases when the body heat loss exceeds the heat emission. Untimely regulation of heat exchange processes can lead to various occupational diseases, frostbite, and even death. Hypothermia is promoted by physical fatigue, high humidity and strong wind. The results of the work show that in order to reduce the level of occupational diseases and improve the heat exchange processes of employees working in low temperature conditions it is necessary to provide them with special warmed work clothes with additional heating element (sodium acetate heating pad). Such clothes will provide comfortable thermal conditions in the underwear of the worker.
ROLE OF PERSONAL CENTRATION OF HIGHER SCHOOL TEACHER IN MODERN CONDITIONS
Authors: Labach M.
Published: October 2018

The problem of the teacher’s personal centration is extremely relevant nowadays due to the challenges that arise in the society and the educational environment under the influence of civilizational changes in the world. The negative contradictions of the post-Soviet society (the society was marked by strongly developed collectivist consciousness), the powerful ultra-fast development of information technologies, and other factors in the educational environment require adequate responses from participants of the pedagogical interaction. New conditions encourage the intensification of facilitation teaching, which is currently developing in the world and in Ukraine as the most appropriate to the humanistic ideas of pedagogical science, directing all the attention to the personality of a learner. Therefore, formation of a person, ready to express his or her opinion freely, to be individual, to take responsibility for himself/herself and to declare himself - that is the task of a personally centered teacher in the modern conditions.
TECHNOLOGIES AND COMPUTER SIMULATORS FOR TASK TRAINING DURING CHEMICAL EMERGENCIES
Authors: Yemelyanenko S. O.
Published: October 2018

In modern educational practice simulators are becoming more common and more accessible means for professional training of recuers. The use of computer training complexes creates the preconditions for better learning of educational material, which is necessary during real rescue activites on chemically hazardous objects. This allows to form emergency preparedness of future rescuers. Conducted analysis show that appropriate methodologies considering introduction of computer training complexes to the educational process must be developed and approved by the State Emergency Service of Ukraine.