bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Optical Nanofibers for Atom-Photon Hybrid Quantum Systems: Chirality Effects and Optical Forces
Authors: Mohammed Aldawsari Haya , Bougouffa Smail
Published: November 2023

Recent advancements have revealed the growing effectiveness of optical nanofibers in enabling the implementation of atom-photon hybrid quantum systems. These nanofibers serve as non-intrusive tools for probing cold atoms, offering a unique approach to circumvent the limitations imposed
by the Rayleigh domain, thereby achieving increased intensities in a beam of light over long distances. This study investigates the interaction between the atom and light, focusing on the dipole transition in sodium atoms near a nanofiber. Notably, we uncover the influence of the direction
of light propagation, known as the optical chirality effect, on the spatial distribution of the steady-state density matrix elements. Furthermore, we examine the optical forces acting on a two-level atom during the 32S1/2 →32P3/2
transition in sodium. Our findings demonstrate that optical chirality’s effect significantly impacts the magnitude of these optical forces. The concept of optical chirality holds great promise for advancing technology and enhancing our understanding of atomic behavior. The numerical
results presented in this work are based on experimental parameters within a realistic range.
Unsupervised Classification of Non-Gaussian Terrain Based on Polarimetric Decomposition
Authors: Huang Zhi-Zhong , Zheng Lin , Yin Wan-Jun
Published: November 2023

Polarimetric synthetic aperture radar (PolSAR) can provide complete polarization property of terrain. Terrain classification is the most common application of PolSAR data. In this paper, an unsupervised clustering algorithm based on Freeman-Durden decomposition (FDD) and a non-Gaussian
K-Wishart distribution classifier is proposed. This algorithm combines an advanced statistical distribution with spatial polarization scattering information of multi-looks PolSAR data. We use the prior probability characteristics of the Markov random field model to adaptively adjust
the cluster center to make the classification more accurate. The experiment result shows that the proposed algorithm based on non-Gaussian models can better retain the polarization information of the target and the clustering accuracy was effectively improved on the real SAR images.
Short Distance Detection and Control System Based on Photoelectric Sensor and Its Application in Target Detection of Handling Robot
Authors: Lu Yaping
Published: November 2023

The photoelectric sensor is an electronic device that is widely used in industrial automation processes. The device uses light to detect whether an object exists. The photoelectric sensor detection control system is the core part of the photoelectric sensor. The system includes sensor
processing chip, control circuit, detection optical structure and automatic teaching control algorithm. In this research, the core control chip of the automatic teaching system and the core part of the control circuit of the short-distance photoelectric sensor are set up. The modular circuit
around the above chip is designed. The optical structure of the sensor is designed by Position sensitive sensor (PSD) photoelectric accessories and triangulation method. Meanwhile, the core circuit control chip (CSP) is applied to complete the basic functions of the short-distance photoelectric
sensor. Among them, the optical structure is designed to collect and process the optical signal of the detected object. Based on this, the I/V conversion is needed after collecting the optical signal by PSD, and then the signal processing is carried out. The fuzzy PID control model is used
to solve the problem that the control object cannot accurately establish the mathematical model. The designed photoelectric sensor is used for the handling robot, and the D-H mathematical model of the handling robot is established. The Robotics toolbox provided by MatLab is used to simulate
the movement of the robot, and the sensor is used to detect the target of the robot grabbing. The experimental results show that the sensor uploads the coordinate information of the object to be grabbed to the software interface, and the handling robot can accurately grab the object with the
help of the photoelectric sensor, and place it in the corresponding position according to the appearance color of different objects to be grabbed.
Research on 3D Point Cloud Classification Based on Density-Based Spatial Clustering of Algorithm with Noise
Authors: He Keren , Chen Hang
Published: November 2023

The classification of three-dimensional point clouds is a complex task because of its disorder and uneven density. This paper proposes that in the point-cloud preprocessing stage, the Density-Based Spatial Clustering of Algorithm with Noise (DBSCAN) is added to cluster the three-dimensional
point cloud, then the clustering results are extracted through the PointNet deep learning network to extract the characteristics of the local area, thus outputting the classification results of the point cloud. This method can not only reflect the feature distribution of point cloud in three-dimensional
space, but also can be divided into several classes according to the different shape features of point cloud. Verified in the ModelNet10 and ModelNet40 point cloud dataset, the classification accuracy of this method on both ModelNet10 and ModelNet40 can reach more than 92.5%.
Design and Analysis of Static Random-Access Memory FinFET Circuit Using Self Controlled Voltage Level Controller
Authors: Rao Gadipudi VishnuVardhan , Kavitha A.
Published: November 2023

Researchers in the field of device research are always searching for a device that meets certain criteria, such as having low leakage and a low threshold voltage, without sacrificing performance. This pursuit has led to the development of numerous gate architectures. As a result of
the enormous size of the static random-access memory (SRAM), its yield and leakage power consumption account for the majority of the chip’s total yield and leakage power consumption respectively. However, as CMOS technology continues to grow in the sub-65 nanometer domain to lower the
cost of transistors and the dynamic power, it presents a number of issues on the design of SRAM. In this paper, a 6T SRAM cell with differential write and single ended read operations working in the near-threshold region is proposed. The structure is based on modifying a recently proposed
6T cell which uses high and low VTH transistors to improve the read and write stability. Also, the changes of cell parameters when the temperature rises from 40 °C to 100 °C are investigated. Finally, the write margin as well as the read and hold SNMs of the cell are studied at two
supply voltages of 400 mV and 500 mV.
The Impact of a Thick-Doping-Layer on the Charge Collection Efficiency in the P-Type Silicon Substrate of EBCMOS Devices
Authors: Qin Xulei , Shi Qidong , Shi Feng , Li Ye , Song De
Published: November 2023

In order to improve the charge collection efficiency of EBCMOS, we predicted and experimentally confirmed the doping structure of the electron multiplication layer. In this study, we simulate the charge collection efficiency of EBCMOS using various doping strategies by modeling the
collisional scattering of electrons with solid atoms in semiconductor materials and combining the travel paths of electrons in the electron multiplication layer. The simulation findings demonstrate that the electric field distribution in EBCMOS could be optimized by using a layered doping
structure to decrease the thickness of the index strongly doped layer. The enhanced doping structure directly contributes to the enhanced charge collecting efficiency. Based on the results of the simulations, doped samples were created and evaluated. The charge collection efficiency of EBCMOS
devices might be significantly increased by decreasing the thickness of the index highly doped layer to 0.1 μm, reaching 86.27%. The testing was done on a 7 μm thick P-type silicon substrate with a 1 μm thick index highly doped layer.
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
Authors: Gong Yang , Yu Tingting , Shuai Wei , Chen Tao , Zhang Jingjing , Huang He
Published: November 2023

Background

Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The role of USP38, a member of the ubiquitin-specific protease family, on MI-induced atrial inflammation, fibrosis, and associated AF is unclear.

Methods

In this study, we surgically constructed a mouse MI model using USP38 cardiac conditional knockout (USP38-CKO) and cardiac-specific overexpression (USP38-TG) mice and applied biochemical, histological, electrophysiological characterization and molecular biology to investigate the effects of USP38 on atrial inflammation, fibrosis, and AF and its mechanisms.

Results

Our results revealed that USP38-CKO attenuates atrial inflammation, thereby ameliorating fibrosis, and abnormal electrophysiologic properties, and reducing susceptibility to AF on day 7 after MI. USP38-TG showed the opposite effect. Mechanistically, The TAK1/NF-κB signaling pathway in the atria was significantly activated after MI, and phosphorylated TAK1, P65, and IκBα protein expression was significantly upregulated. USP38-CKO inhibited the activation of the TAK1/NF-κB signaling pathway, whereas USP38-TG overactivated the TAK1/NF-κB signaling pathway after MI. USP38 is dependent on the TAK1/NF-κB signaling pathway and regulates atrial inflammation, fibrosis, and arrhythmias after MI to some extent.

Conclusions

USP38 plays an important role in atrial inflammation, fibrosis, and AF susceptibility after MI, providing a promising target for the treatment of AF after MI.
Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study
Authors: Legdeur Nienke , Moonen Justine E. , Badissi Maryam , Sudre Carole H. , Pelkmans Wiesje , Gordon Mark Forrest , Barkhof Frederik , Peters Mike , Visser Pieter Jelle , Muller Majon
Published: November 2023

Background

Prior studies suggest a changing association between blood pressure (BP) and cognition with aging, however work in the oldest-old has yielded ambiguous results. Potentially, these mixed results can be explained by modifying factors. The aim of this study was to establish whether physical, vascular or brain pathology markers that describe a state of increased vulnerability, affect the association between BP and cognition in the oldest-old. Results may influence clinicians’ decisions regarding the use of antihypertensives in this age group.

Methods

We included 122 individuals (84 without cognitive impairment and 38 with cognitive impairment) from the EMIF-AD 90 + Study (mean age 92.4 years). First, we tested cross-sectional associations of systolic and diastolic BP with a cognitive composite score. Second, we tested whether these associations were modified by physical markers (waist circumference, muscle mass, gait speed and handgrip strength), vascular markers (history of cardiac disease, carotid intima media thickness as a proxy for atherosclerosis and carotid distensibility coefficient as a proxy for arterial stiffness) or brain pathology markers (white matter hyperintensities and cortical thickness).

Results

In the total sample, there was no association between BP and cognition, however, waist circumference modified this association (p-value for interaction with systolic BP: 0.03, with diastolic BP: 0.01). In individuals with a high waist circumference, higher systolic and diastolic BP tended to be associated with worse cognition, while in individuals with a low waist circumference, higher systolic BP was associated with better cognition. The others physical, vascular and brain pathology markers did not modify the association between BP and cognition.

Conclusions

When examining various markers for physical, vascular and brain vulnerability, only waist circumference affected the association between BP and cognition. This warrants further research to evaluate whether waist circumference may be a marker in clinical practice influencing the use of antihypertensives in the oldest-old.
Novel biomarkers to predict treatment response and prognosis in locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy
Authors: Guan Bingjie , Xu Meifang , Zheng Rong , Guan Guoxian , Xu Benhua
Published: November 2023

Purpose

To identify genes associated with treatment response and prognosis for locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (NCRT).

Methods

In our cohort, gene expression profiles of 64 tumor biopsy samples before NCRT were examined and generated. Weighted gene co-expression network analysis was performed to identify gene modules. External validation datasets included GSE3493, GSE119409, and GSE133057. The expression of candidate genes was evaluated using immunohistochemistry (IHC). TIMER was used to assess immune infiltration.

Results

We identified and validated the capability to predict the treatment response of CCT5 and ELF1 using our data and external validation datasets. The trends of survival differences of candidate genes in the GSE133057 dataset were similar to our cohort. High levels of CCT5 and ELF1 expression were associated with NCRT resistance and poor prognosis. Furthermore, the expression of CCT5 and ELF1 were also assessed in 117 LARC patients’ samples by the IHC method. Based on IHC results and Cox analysis, the risk score model with CCT5 and ELF1 was constructed and performed well. The risk score was an independent prognostic factor for progression-free survival and overall survival in LARC patients and was then used to build nomogram models. The underlying mechanisms of CCT5 and ELF1 were explored using gene set enrichment analysis. The underlying pathway including apoptosis, cell cycle, and other processes. CCT5 and ELF1 expressions were significantly correlated with immune cell infiltration.

Conclusion

CCT5 and ELF1 were determined as biomarkers for treatment response and prognosis in LARC patients. The risk score model and nomograms helped predict treatment response and survival outcomes for LARC patients undergoing NCRT.
Evaluation of the Acute flaccid paralysis surveillance indicators in Zambia from 2015–2021: a retrospective analysis
Authors: Bessing Barnabas , Dagoe Edward A. , Tembo Deborah , Mwangombe Alice , Kanyanga Muzala K. , Manneh Fadinding , Matapo Belem B. , Bobo Patricia M. , Chipoya Musole , Eboh Victor A. , Kayeye Princess L. , Masumbu Penelope K. , Muzongwe Chilweza , Bakyaita Nathan N. , Zomahoun Delayo , Tuma Jude N.
Published: November 2023

Background

The resurgence of poliovirus infection in previously polio free regions and countries calls for renewed commitment to the global polio eradication efforts including strengthening of Acute Flaccid Paralysis (AFP) surveillance systems. Zambia is one of the countries substantially at risk for the importation of poliovirus infection from neighbouring countries including Malawi, Mozambique, and Democratic Republic of the Congo (DRC). This study describes a seven-year AFP surveillance, assesses the surveillance indicators, and highlights areas for improvement.

Methods

We conducted retrospective analysis of the routinely collected AFP surveillance data from January 2015 to December 2022. The AFP surveillance indicators performance was assessed using the World Health Organisation’s recommended minimum AFP surveillance indicators performance.

Results

Cumulatively, a total of 1715 AFP cases were reported over the study period. More than half, 891 (52%) of reported cases were aged < 5 years with 917 (53.5%) of males. More than half, 1186 (69.2%) had fever at onset, 718 (41.9%) had asymmetric paralysis and 1164 (67.9%) had their paralysis progressed within 3 days of onset. The non-polio AFP rate ranges from 3.4 to 6.4 per 100,000 children < 15 years old and stool adequacy ranging from 70.9% to 90.2% indicating sensitive surveillance with late detection of cases. The percentage of cases with early stool collection, timely transportation was above the World Health Organisation (WHO) minimum of 80% but with declining proportion of stools arriving in the laboratory in optimal condition. Completeness of 60-days follow-up evaluation was suboptimal ranging from 0.9% to 28.2%.

Conclusion

The AFP surveillance system in Zambia is doing well. However, additional efforts are needed to improve early detection of cases; stool sample collection, transportation and monitoring to ensure arrival in good condition in the laboratory; and improve 60-days follow-up evaluation for evidenced-based classification of inadequate AFP cases and proper care.
The effectiveness of simulation-based education combined with peer-assisted learning on clinical performance of first-year medical residents: a case-control study
Authors: Murakami Taku , Yamamoto Akira , Hagiya Hideharu , Obika Mikako , Mandai Yasuhiro , Miyoshi Tomoko , Kataoka Hitomi , Otsuka Fumio
Published: November 2023

Background

Simulation-based education and peer-assisted learning (PAL) are both known as useful educational methods. Previous research has reported that combining these two methods are effective for training medical residents in short-term evaluation. This study was aimed to evaluate the middle- to long-term effects of simulation-based education combined with PAL on the performance of medical residents during emergency department duties.

Methods

This study was designed as a case-control study and conducted over three years at Okayama University Hospital in Japan. Postgraduate-year-one medical residents were assigned to three groups: a simulation group that received simulation-based education, a lecture group that received traditional lecture-based education, and a control group that received no such prior trainings. Prior training in emergency department duties using PAL was performed as an educational intervention for the simulation and lecture groups during the clinical orientation period. The residents’ medical knowledge was assessed by written examinations before and after the orientation. The performance of residents during their emergency department duties was assessed by self-evaluation questionnaires and objective-assessment checklists, following up with the residents for three months after the orientation period and collecting data on their 1st, 2nd, and 3rd emergency department duties. All the datasets collected were statistically analyzed and compared by their mean values among the three groups.

Results

A total of 75 residents were included in the comparative study: 27 in the simulation group, 24 in the lecture group, and 24 in the control group. The simulation and lecture groups obtained significantly higher written examination scores than the control group. From the self-evaluation questionnaires, the simulation group reported significantly higher satisfaction in their prior training than the lecture group. No significant differences were found in the emergency department performance of the residents among the three groups. However, when evaluating the improvement rate of performance over time, all three groups showed improvement in the subjective evaluation, and only the simulation and lecture groups showed improvement in the objective evaluation.

Conclusion

Simulation-based education combined with PAL is effective in improving the knowledge and satisfaction of medical residents, suggesting the possibility of improving work performance during their emergency department duties.
Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression
Authors: Zhou Jie , Li Peiwei , Zhao Xiaogang , Zhao Yuanhao , Luo Junwen , Deng Yupeng , Jiang Ning , Xiao Zhaohua , Zhang Wenhao , Zhou Yongjia , Zhao Jiangfeng , Li Peichao , Li Yuliang , Tian Zhongxian
Published: November 2023

Background

Lung cancer represents a significant public health issue in China, given its high incidence and mortality rates. Circular RNAs (circRNAs) have been recently proposed to participate in the development and progression of tumors. Nevertheless, their particular roles in the pathogenesis of lung adenocarcinoma (LUAD), the tumor microenvironment (TME), and the underlying molecular mechanisms are still not well understood.

Methods

High-throughput sequencing was used to analyze the circRNAs expression profiles in 7 pairs of human LUAD tissues. shRNA was used to knockdown the YAP1 and FGB genes. RNA sequencing and RT-qPCR were performed to classify the regulatory effects of circ_16601 in LUAD cells. The progression effect of circ_16601 on lung cancer was investigated in vitro and in vivo.

Results

The circ_16601 is significantly elevated in LUAD tissues compared to adjacent normal lung tissues, and its high expression is positively associated with poor prognosis in LUAD patients. Additionally, circ_16601 overexpression promotes LUAD cell proliferation in vitro and increases xenograft tissue growth in mice in vivo; circ_16601 also could recruit fibroblasts to cancer associate fibroblasts. Mechanistically, circ_16601 can directly bind to miR-5580-5p, preventing its ability to degrade FGB mRNA and enhancing its stability. Subsequently, circ_16601 promotes the activation of the Hippo pathway in a YAP1-dependent manner, leading to LUAD progression.

Conclusions

Our findings shed valuable insights into the regulatory role of circ_16601 in LUAD progression and highlight its potential as a diagnostic and therapeutic target in LUAD. Overall, this study provides theoretical support to improve the prognosis and quality of life of patients suffering from this devastating disease.
NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage
Authors: Chen Ping , Liu Xue-Yan , Lin Mou-Hui , Li Yu-Xi , Kang De-Zhi , Ye Zu-Cheng , Lin Qing-Song
Published: November 2023

Background

Subarachnoid hemorrhage (SAH) causes significant long-term neurocognitive dysfunction, which is associated with hippocampal neuroinflammation. Growing evidences have shown that astrocytes played a significant role in mediating neuroinflammation. Recently, in vivo reprogramming of astrocytes to neurons by NeuroD1 or PTBP1 administration has generated a lot of interests and controversies. While the debates centered on the source of neurogenesis, no attention has been paid to the changes of the astrocytes-mediated neuroinflammation and its impact on endogenous neurogenesis after NeuroD1 administration.

Methods

80 adult male C57BL/6 mice were used in this study. SAH was established by pre-chiasmatic injection of 100 μl blood. AAV–NeuroD1–GFP virus was injected to the hippocampus 3 day post-SAH. Neurocognitive function, brain water content, in vivo electrophysiology, Golgi staining, western blot and immunofluorescent staining were assessed at day 14 post-virus injection.

Results

NeuroD1 administration markedly attenuated reactive astrocytes-mediated neuroinflammation by reversing neurotoxic A1 astrocytes transformation, decreasing the secretion of neuroinflammatory cytokines, and reducing the activation of harmful microglia. NeuroD1 treatment significantly reversed the brain–blood barrier impairment and promoted the release of neurotrophic factors pleiotrophin (PTN), all of which contributed to the improvement of cellular microenvironment and made it more suitable for neurogenesis. Interestingly, besides neurogenesis in the hippocampus from cells transfected with NeuroD1 at the early phase of SAH, NeuroD1 administration significantly boosted the endogenous neurogenesis at the late phase of SAH, which likely benefited from the improvement of the neuroinflammatory microenvironment. Functionally, NeuroD1 treatment significantly alleviated neurocognitive dysfunction impaired by SAH.

Conclusions

NeuroD1 significantly promoted neurofunctional recovery by attenuating reactive astrocytes-mediated neuroinflammation and boosting neurogenesis decimated by SAH. Specifically, NeuroD1 efficiently converted transfected cells, most likely astrocytes, to neurons at the early phase of SAH, suppressed astrocytes-mediated neuroinflammation and boosted endogenous neurogenesis at the late phase of SAH.
Optimization of hydraulic design of approach channel of spillway by hydraulic model studies
Authors: Ramarao Vankayalapati S. , Reddy Mutukuru G. Muni , Sahu Kanhu C.
Published: November 2023

The approach channel is intended to divert the flow safely from its original course and the diversion may be intended towards spillway, power intake or any other hydraulic structure. The hydraulic design of the approach channel involves determining cross-section dimensions of the channel for the design flood at a given flow velocity, slope and shape or alternatively determining the discharge capacity for the given layout and cross-section dimensions. Proper alignment of approach channel minimizes the head loss by reducing the oblique flows. Sometimes, the spillway approach channel is submerged with unconfined boundaries, asymmetrical in layout. However, these conditions are site-specific. Hydraulic model studies play a substantial role in testing these kinds of layouts to find out an optimum layout. Studies have been carried out on a 1:140 scale model of the spillway to optimize the layout of an unconfined, unlined, asymmetrical, and submerged approach channel by the assessment of velocity profiles and flow pattern in the approach channel for different shaped layouts. Studies indicated that the efficient layout of the approach channel is governed by its maximum available width and straightforward approach, prevention of lateral inflows by the provision of additional embankments and provision of suitable length of the guide bund.
Paradigm Shift in the Management of Metabolic Diseases—Next-Generation Incretin Therapy
Authors: Ahrén Bo
Published: November 2023

Recently impressive weight loss has been reported for novel incretin therapies based on dual-and triple-hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases for which weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases, and nonalcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.
Military macroconcepts of Russian linguoculture
Authors: Bodrikov Aleksey B.
Published: November 2023

Работа выполнена в русле лингвокультурологии и когнитивистики и посвящена рассмотрению милитарных макроконцептов - макроментальных образований, отличающихся сложной структурой. В исследовании рассмотрены милитарные макроконцепты армия, войско, дружина в русской лингвокультуре. Рекомендуется студентам, магистрантам, аспирантам, а также специалистам в области лингвоконцептологии, лингвокультурологии, когнитивной и аксиологической лингвистики.
Temperament and attachment dimensions as predictors for impairments of personality functioning according to DSM-5
Authors: Machowicz Małgorzata , Cieciuch Jan
Published: November 2023

Cel pracy

Celem badania było określenie roli wymiarów temperamentu i przywiązania dla zaburzeń osobowości, definiowanych zgodnie z kryterium A z DSM-5, jako nieprawidłowości w funkcjonowaniu intrapsychicznym i interpersonalnym.

Metoda

Badanie zostało przeprowadzone w Polsce w grupie 391 uczestników. Wykorzystano w nim następujące narzędzia: Krótką Skalę Poziomu Funkcjonowania Osobowości LPFS-BF 2.0 (Level of Personality Functioning Scale-Brief Form 2.0), Kwestionariusz Metawymiarów Temperamentu TMQ (Temperament Metadimensions Questionnaire), Kwestionariusz Stylu Przywiązania ASQ (Attachment Style Questionnaire) oraz Zrewidowaną Skalę Doświadczeń w Bliskich Związkach ECR-R ( Experiences in Close Relationships-Revised).

Wyniki

Łączne oszacowanie znaczenia temperamentu oraz przywiązania dla wyjaśniania nieprawidłowości w funkcjonowaniu osobowości doprowadziło do następujących konkluzji: (1) Temperament w większym stopniu wyjaśniał nieprawidłowości w funkcjonowaniu intrapsychicznym niż interpersonalnym. (2) Predyktorem zaburzeń osobowości była w większym stopniu temperamentalna Reaktywność niż Aktywność. (3) Dodanie przywiązania zwiększyło wielkość wyjaśnionej wariancji zaburzeń osobowości. (4) Przywiązaniowe Unikanie w większym stopniu wyjaśniało nieprawidłowości w funkcjonowaniu interpersonalnym, podczas gdy przywiązaniowy Lęk w większym stopniu wyjaśniał nieprawidłowości w funkcjonowaniu interpersonalnym.

Wnioski

Nieprawidłowości w funkcjonowaniu osobowości ujęte w Kryterium A DSM-5 są w znacznym stopniu wyjaśniane dwoma rodzajami zmiennych: bardziej trwałym i wrodzonym temperamentem oraz nabytym w toku wczesnych interakcji przywiązaniem. Takie rozróżnienie jest istotne z perspektywy klinicznej, w której skuteczne oddziaływania mogą być nakierowane na te właściwości, które mogą podlegać modyfikacji oraz brać pod uwagę te, których modyfikacja jest trudna lub niemożliwa.
MECHANICAL PROPERTIES OF COMPOSITES CONTAINING EXFOLIATED-GRAPHITE/EPOXY SENSORS
Authors: VERBOSKY ARIANNA L. , ZEGEYE EPHRAIM F. , REED QUINN T.
Published: November 2023

One structural health monitoring (SHM) approach involves the embedding of sensors within a composite. However, embedded sensors may act as defects and could affect the composite’s mechanical properties. The objective of this study is to determine the effects of embedding exfoliated graphite (EG)/epoxy sensors on the mechanical properties of the hosting composite system. EG/epoxy composite sensor strips with two different volume fractions were fabricated. Two sets of tensile test specimens were fabricated by embedding the sensors in the epoxy system along the length and width directions of the test specimens. To develop a data baseline, EG/epoxy tensile test specimens were also fabricated. Tensile tests were performed on the samples and the results were analyzed to determine the effects of the embedded sensors on the composite material’s elastic modulus and tensile strength. The addition of EG slightly increased the elastic modulus and tensile strength of the samples. For test samples containing the sensor strips, the orientation of the sensors has a significant effect on the composite’s mechanical properties. Samples containing sensors along the widthwise direction were observed to have a lower tensile strength, and this is attributed to the observed delamination along the edge of the sensors.
CRITICAL PROGRESSIVE DAMAGE ANALYSIS MODEL FEATURES FOR LOW-VELOCITY IMPACT ON THERMOSET AND THERMOPLASTIC PANELS
Authors: LEONE FRANK , JACKSON WADE , ROSE CHERYL , SESHADRI BANAVARA
Published: November 2023

A previous verification and validation framework evaluated the ability of various progressive damage analysis (PDA) tools to predict the mechanical response and damage state in post-buckled stiffened aerospace structures composed of fiberreinforced thermoset composite materials. Herein, the ability of PDA tools to predict damage in thermoplastic composite materials subject to low-velocity impact (LVI) loading has been assessed. LVI tests and analyses have been conducted for similar panels, comprising thermoset or thermoplastic composite materials. Preliminary test/analysis correlations revealed that using the same combination of PDA model features and finite element model-building guidelines for the thermoset and thermoplastic LVI specimens resulted in underprediction of matrix crack lengths and delaminated area in the thermoplastic analyses despite yielding good correlations for the thermoset specimens. In this paper, the quality of the test/analysis correlations for analyses of thermoplastic LVI specimens performed with different combinations of PDA model features using the NASA CompDam material model are presented. Model features that were assessed in terms of effect on the quality of the test/analysis correlation include the representation of damageable interfaces, residual thermal stresses, and fiber damage.
PROPERTIES OF DECONSTRUCTABLE FRONTALLY CURED FIBER-REINFORCED THERMOSET COMPOSITES
Authors: PRICE TYLER C. , COOPER JULIAN C. , MEJIA EDGAR B. , IVANOFF DOUGLAS G. , PARIKH NIL A. , HUSTED KEITH E. L. , LE THIEN B. , FILMAN BENJAMIN D. , JOHNSON JEREMIAH A. J , MOORE JEFFREY S. , SOTTOS NANCY R.
Published: November 2023

Fiber-reinforced thermoset polymer matrix composites (FRPCs) possess the chemical, physical, and mechanical properties required for applications in critical industries such as defense, transportation, and energy. However, thermoset FRPCs lack sustainable end-of-life management strategies that recapture their desirable thermomechanical properties. Frontal curing with cleavable comonomers is a promising strategy to extend the lifecycle of constituent materials used in FRPCs by decreasing manufacturing cost and improving end-of-life management with little impact on thermomechanical performance. Here, we demonstrate energy efficient, out-of-autoclave manufacturing and fiber reclamation in high-performance carbonfiber/ poly(dicyclopentadiene) (CF/pDCPD) FRPCs. Through vacuum assisted resin transfer molding (VARTM) and through thickness frontal curing, we produce deconstructable high-performance (Vf ~ 50 %, Vv < 2 %) FRPCs with glass transition temperatures over 140°C using four orders of magnitude less energy than conventional bulk curing. We achieve chemical deconstruction by cleaving silyl-ether-containing comonomers and crosslinkers incorporated in the matrix. We recover the oligomeric fragments of the matrix and the in-tact woven fibers. The reclaimed fibers have excellent integrity and show minimal visual evidence of matrix residue. The thermomechanical performance of the deconstructable FRPCs presented is a step towards efficiently manufacturing sustainable FRPCs that do not compromise performance.
The Local Anesthetic Activity of Lavandula angustifolia and Eugenia caryophyllata Essential Oils
Authors: Uthirapathy Subasini
Published: November 2023

Previous studies show that Lavandula angustifolia (lavender) and Eugenia caryophyllata (clove) essential oils can help relieve dental pain. Clove oil and lavender oil were tested as topical anesthetics in this study on rabbits, and their effects and likely mechanisms of action were analyzed. Clove oil and lavender oil were extracted by hydrodistillation using a Clevenger-setup apparatus. Topically applying lidocaine, clove oil, or lavender oil topically all significantly reduced corneal sensitivity. The sensitivity of the cornea was successfully reduced by treatments consisting of lidocaine at a concentration of 0.5%, 25 μg of clove oil, and 50 μg of lavender oil. When clove oil is applied topically to the cornea, it produces effects similar to those of a local anesthetic due to the involvement of the cholinergic system. To achieve the desired effect of producing local anesthesia in the cornea of the rabbit, lidocaine, clove oil, and lavender oil were applied topically to the animal. A noticeable local

anesthetic effect was produced when sub-anesthetic doses of lidocaine were combined with sub-anesthetic doses of lavender or clove oil.
University of Patras: A "Green" University? A Case Study of a Greek University Institution
Authors: Kavasakalis Aggelos , Sidiropoulou Kyriaki
Published: November 2023

The unprecedented intensity of climate change shows how urgent the need to make our societies more sustainable is. It is therefore positive that many enterprises and educational organizations worldwide are making efforts to integrate the principles of sustainable development into their way of operating. The aim of this article is to highlight the research findings on the actions and processes adopted in a Greek university, the University of Patras, to promote sustainability and ‘green’ operation. It is a qualitative survey conducted at the University of Patras with the participation of 13 professors of the university as the key - actors as they: a) teach relevant courses, b) participate in relevant actions, c) hold (at the time of the research) positions of responsibility in the leadership of the university. By generating the data, through the use of thematic analysis of official university texts and semi-structured interviews it is concluded that this university is in an early stage of transformation to a green operating model.
A Decade-Long Roadmap to Understanding and Accommodating IB Students at a Japanese National University
Authors: Sabina Mahmood
Published: November 2023

Okayama University is a Super Global National University in Japan that introduced IB admissions in 2012 and proudly celebrates 11 years this year. As of April 2023, 122 IB students from IB schools in Japan and abroad have enrolled in 10 Faculties and 1 International Program. During the first decade of IB admissions, Okayama University gradually transitioned into one of the most IB-friendly Universities in Japan, not only among prospective IB students but also their family members and IB college counselors. A significant reason for this was due to the efforts put in by Okayama University to continuously obtain feedback from enrolled IB students regarding their needs, their hurdles, and their suggestions on how to improve their academic and campus lives. Student support and student voices merged as powerful resources for Okayama University to improve the overall condition of IB students from entry to graduation and created a robust platform for welcoming prospective IB students, who became Okayama University’s brand ambassadors following admission. Successful IB admissions result from a balance between what Universities have to offer IB students and what IB Students want. This paper will include a detailed description of the changes made by Okayama University regarding modifying IB admission guidelines, strengthening the IB student support system, and establishing the IB Office to better cater to IB student needs. Other highlights will emphasize the importance of understanding IB student backgrounds, IB education, and IB research by University representatives to make admission policies compatible with global higher education standards from the hands-on experience of Faculty members at Okayama University.
PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization
Authors: Wei Dongyu , Birla Hareram , Dou Yannong , Mei Yixiao , Huo Xiaodong , Whitehead Victoria , Osei-Owusu Patrick , Feske Stefan , Patafio Giovanna , Tao Yuanxiang , Hu Huijuan
Published: November 2023

Peripheral sensitization is one of the primary mechanisms underlying the pathogenesis of chronic pain. However, candidate molecules involved in peripheral sensitization remain incompletely understood. We have shown that store-operated calcium channels (SOCs) are expressed in the dorsal root ganglion (DRG) neurons. Whether SOCs contribute to peripheral sensitization associated with chronic inflammatory pain is elusive. Here we report that global or conditional deletion of Orai1 attenuates Complete Freunds adjuvant (CFA)-induced pain hypersensitivity in both male and female mice. To further establish the role of Orai1 in inflammatory pain, we performed calcium imaging and patch-clamp recordings in wild-type (WT) and Orai1 knockout (KO) DRG neurons. We found that SOC function was significantly enhanced in WT but not in Orai1 KO DRG neurons from CFA- and carrageenan-injected mice. Interestingly, the Orai1 protein level in L3/4 DRGs was not altered under inflammatory conditions. To understand how Orai1 is modulated under inflammatory pain conditions, prostaglandin E2 (PGE2) was used to sensitize DRG neurons. PGE2-induced increase in neuronal excitability and pain hypersensitivity was significantly reduced in Orai1 KO mice. PGE2-induced potentiation of SOC entry (SOCE) was observed in WT, but not in Orai1 KO DRG neurons. This effect was attenuated by a PGE2 receptor 1 (EP1) antagonist and mimicked by an EP1 agonist. Inhibition of Gq/11, PKC, or ERK abolished PGE2-induced SOCE increase, indicating PGE2-induced SOCE enhancement is mediated by EP1-mediated downstream cascade. These findings demonstrate that Orai1 plays an important role in peripheral sensitization. Our study also provides new insight into molecular mechanisms underlying PGE2-induced modulation of inflammatory pain.

Significance Statement
Store-operated calcium channel (SOC) Orai1 is expressed and functional in dorsal root ganglion (DRG) neurons. Whether Orai1 contributes to peripheral sensitization is unclear. The present study demonstrates that Orai1-mediated SOC function is enhanced in DRG neurons under inflammatory conditions. Global and conditional deletion of Orai1 attenuates complete Freunds adjuvant (CFA)-induced pain hypersensitivity. We also demonstrate that prostaglandin E2 (PGE2) potentiates SOC function in DRG neurons through EP1-mediated signaling pathway. Importantly, we have found that Orai1 deficiency diminishes PGE2-induced SOC function increase and reduces PGE2-induced increase in neuronal excitability and pain hypersensitivity. These findings suggest that Orai1 plays an important role in peripheral sensitization associated with inflammatory pain. Our study reveals a novel mechanism underlying PGE2/EP1-induced peripheral sensitization. Orai1 may serve as a potential target for pathological pain.
Basic methodological approaches and applied mechanisms of transition to nationally rooted development in the agri-food system of Ukraine
Authors:   State Institution “Institute for Economics and Forecasting, NAS of Ukraine”, Borodina Olena
Published: November 2023

The article, referring to the newest methodology of global agri-food systems’ transformation, substantiates that the determining direction of changes in the Ukrainian agri-food system towards nationally rooted development should be the need for free access to high-quality, fresh and safe food and domestically produced agricultural outputs, obtained in a way that is safe for the environment and rural communities, based on stimulating national food markets and outputs that are produced, processed, sold (distributed) and consumed in a certain territory based on stimulating supply and demand. It is shown that the mechanisms of food supply, in such circumstances, are not inflationary, since supply and demand are linked to and balanced by the state indirect financing of the basic human right to domestically produced food and stimulation of solidarity responsibility for food production and consumption. The author proposes various effective and feasible basic approaches to enhancing the role of local markets in food systems oriented towards people's interests rather than traditional economic growth, including linked food subsidies to promote healthy diets; public procurement from small producers for special needs of school meals; and promotion of solidarity food security at the community level. The article shows that such food programmes, along with other social protection initiatives, are one of the most reasonable directions for long-term public investment, especially if they are focused on linked multiplier effects. A nationally rooted approach to stimulating local markets has been shown to not only provide the most vulnerable groups with quality food and promote the consumption of fresh and healthy food, but also build the sustainability of nutrition programmes, and open up new markets and opportunities to increase family farm incomes, while stimulating local development. Purchasing food from local sources makes markets more predictable, helps create jobs and creates opportunities for people to develop a lifelong preference for fresh local produce.
Influence of international economic entities on the state regulation of economy
Authors:   State Institution “Institute for Economics and Forecasting, NAS of Ukraine”, Trofymchuk Oleh
Published: November 2023

Based on the concept of jointly-divided activities, the paper reveals the essence of the government’s regulation of economy as a sub-function of state’s economic functions, where the government is a bearer of society’s general economic interests. The work substantiates the positive and negative sides of the influence of international economic entities on economic policy by splitting up state’s own functions and state’s applied functions, so that the latter may contradict the former and be not corresponding to the essence of state. The author reveals the main interests of the triad of globalizers – TNCs, international organizations and developed countries. The study shows the asymmetric nature of the interaction between the open economies and the main international economic entities – international organizations and TNCs, which is due to the difference in their interests and opportunities to influence each other. The paper outlines the main causes and consequences of the negative influence of international organizations and TNCs on the government’s economic regulation in developed countries and other open economies. Revealed the problems of imposing unified rules on economic policy in transition economies by international organizations, of setting requirements for crediting, and of promoting the neoliberal concept and the austerity policy. The work analyzes the negative consequences of the influence of TNCs on state economic regulation, namely: the weakening of employees’ bargaining power and the fall of their incomes, the growth of inequality, the reduction of the tax burden on corporations, offshorization, the hypertrophied development of the financial sphere, etc. The study shows various methods to mitigate the consequences of the negative influence of TNCs on open economies. The paper highlights the main mechanisms of influence of international economic entities on state economic regulation. Revealed the main challenges of state economic regulation caused by the increasing influence of international economic entities and globalization in general. Based on these challenges, the paper highlights the following main necessary transformations of state economic regulation: (1) increasing the level of subjectivity of the state as a bearer of national interests, (2) ensuring institutional foundations for inclusive global development based on the principles of equality, justice and transparency, and (3) neutralizing the negative impact on national socio-economic security exerted by international actors.
EFFECTS OF THE INSTITUTIONAL ENVIRONMENT ON THE MARITIME TRANSPORT DEVELOPMENT IN BULGARIA
Authors: Koralova–Nozharova P. , Nozharov Sh.
Published: November 2023

In the last years, the national economies have been subject to sporadic lockdowns, introduction of recurrent regulations for mobility control, supply chain disruptions, liquidation of the economic activity of many sectors. These circumstances have also affected the normal functioning of the transport sector and especially the maritime transport. Dealing with the COVID-19 pandemic and the military conflict in Ukraine, the maritime operators should also meet the requirements of the European green deal, the European emissions trading scheme, digitalizing and maintaining the seafarers’ employment in the sector. In the case of Bulgaria, these challenges are very difficult to overcome because of the institutional environment conditions, therefore, their evaluation is of great importance for the development of the subsector.