bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Potential Intermediates in the Cross-Species Transmission of Influenza A Virus to Humans
Authors: Lee Chung-Young
Published: July 2024

The influenza A virus (IAV) has been a major cause of several pandemics, underscoring the importance of elucidating its transmission dynamics. This review investigates potential intermediate hosts in the cross-species transmission of IAV to humans, focusing on the factors that facilitate zoonotic events. We evaluate the roles of various animal hosts, including pigs, galliformes, companion animals, minks, marine mammals, and other animals, in the spread of IAV to humans.
Temporal Dynamics of Purinergic Receptor Expression in the Lungs of Marek’s Disease (MD) Virus-Infected Chickens Resistant or Susceptible to MD
Authors: Akbar Haji , Jarosinski Keith W.
Published: July 2024

Marek’s disease virus (MDV) is an economic concern for the poultry industry due to its poorly understood pathophysiology. Purinergic receptors (PRs) are potential therapeutic targets for viral infections, including herpesviruses, prompting our investigation into their role in MDV pathogenesis. The current study is part of an experimental series analyzing the expression of PRs during MDV infection. To address the early or short-acting P2 PR responses during natural MDV infection, we performed an “exposure” experiment where age-matched chickens were exposed to experimentally infected shedders to initiate natural infection. In addition, select non-PR regulatory gene responses were measured. Two groups of naïve contact chickens (n = 5/breed/time point) from MD-resistant (White Leghorns: WL) and -susceptible (Pure Columbian) chicken lines were housed separately with experimentally infected PC (×PC) and WL (×WL) chickens for 6 or 24 h. Whole lung lavage cells (WLLC) were collected, RNA was extracted, and RT-qPCR assays were used to measure specific PR responses. In addition, other potentially important markers in pathophysiology were measured. Our study revealed that WL chickens exhibited higher P1 PR expression during natural infection. WL chickens also showed higher expression of P1A3 and P2X3 at 6 and 24 h when exposed to PC-infected chickens. P2X5 and P2Y1 showed higher expression at 6 h, while P2Y5 showed higher expression at 6 and 24 h; regardless of the chicken line, PC chickens exhibited higher expression of P2X2, P2Y8, P2Y10, P2Y13, and P2Y14 when exposed to either group of infected chickens. In addition, MDV infection altered the expression of DDX5 in both WL and PC groups exposed to PC-infected birds only. However, irrespective of the source of exposure, BCL2 and ANGPTL4 showed higher expression in both WL and PC. The expression of STAT1A and STAT5A was influenced by time and breed, with major changes observed in STAT5A. CAT and SOD1 expression significantly increased in both WL and PC birds, regardless of the source of infection. GPX1 and GPX2 expression also increased in both WL and PC, although overall lower expression was observed in PC chickens at 24 h compared to 6 h. Our data suggest systemic changes in the host during early infection, indicated by the altered expression of PRs, DDX5, BCL2, ANGPTL4, and other regulatory genes during early MDV infection. The relative expression of these responses in PC and WL chickens suggests they may play a key role in their response to natural MDV infection in the lungs and long-term pathogenesis and survival.
Quantitative Prediction of Human Immunodeficiency Virus Drug Resistance
Authors: Stolbova Ekaterina A. , Stolbov Leonid A. , Filimonov Dmitry A. , Poroikov Vladimir V. , Tarasova Olga A.
Published: July 2024

Drug resistance of pathogens, including viruses, is one of the reasons for decreased efficacy of therapy. Considering the impact of HIV type 1 (HIV-1) on the development of progressive immune dysfunction and the rapid development of drug resistance, the analysis of HIV-1 resistance is of high significance. Currently, a substantial amount of data has been accumulated on HIV-1 drug resistance that can be used to build both qualitative and quantitative models of HIV-1 drug resistance. Quantitative models of drug resistance can enrich the information about the efficacy of a particular drug in the scheme of antiretroviral therapy. In our study, we investigated the possibility of developing models for quantitative prediction of HIV-1 resistance to eight protease inhibitors based on the analysis of amino acid sequences of HIV-1 protease for 900 virus variants. We developed random forest regression (RFR), support vector regression (SVR), and self-consistent regression (SCR) models using binary vectors containing values from 0 or 1, depending on the presence of a specific peptide fragment in each amino acid sequence as independent variables, while fold ratio, reflecting the level of resistance, was the predicted variable. The SVR and SCR models showed the highest predictive performances. The models built demonstrate reasonable performances for eight out of nine (R2 varied from 0.828 to 0.909) protease inhibitors, while R2 for predicting tipranavir fold ratio was lower (R2 was 0.642). We believe that the developed approach can be applied to evaluate drug resistance of molecular targets of other viruses where appropriate experimental data are available.
Evaluating Factors That Influence Influenza Vaccination Uptake among Pregnant People in a Medically Underserved Area in Washington State
Authors: McKeirnan Kimberly , Brand Damianne , Giruzzi Megan , Vaitla Kavya , Giruzzi Nick , Krebill-Prather Rose , Dang Juliet
Published: July 2024

Introduction: Despite substantial evidence demonstrating the effectiveness of influenza vaccines, only 38.6% of the adult United States population received an influenza vaccine during the 2023–2024 flu season. Vaccination rates are typically lower among U.S. minority groups, and in 2022, pregnant persons from U.S. minority racial and ethnic groups showed a decrease in influenza vaccine coverage. Methods: A survey was conducted with residents of Yakima County, Washington, which is home to one of the state’s largest percentages of people who identify as Hispanic or Latino/a. The objective was to evaluate the uptake of influenza vaccine among pregnant persons. Surveys were sent to a random sample of 3000 residential mailing addresses. Of the 500 respondents, 244 (52.1%) reported that they had been pregnant, with those identifying as Hispanic or Latino/a constituting 23.8% of this total. Only 62 (26.2%) reported being immunized against influenza during pregnancy. Respondents who were immunized against influenza chose to be vaccinated to protect themselves from the flu (85.5%, n = 53); because a healthcare provider recommended getting vaccinated (85.5%, n = 53); to protect the baby from the flu (82.3%, n = 51); because it was available for free or low cost (62.9%, n = 39); and because vaccination was convenient (54.8%, n = 34). Qualitative evaluation identified that participants who were not vaccinated against influenza during pregnancy believed the vaccination was not needed, was not recommended by a healthcare provider, was difficult to access, they were against vaccination in general, or they were concerned about the safety and ingredients of the vaccine. Conclusion: Barriers to vaccination identified in this study included vaccine distrust, lack of awareness, and concerns about vaccine efficacy and safety. Healthcare providers can help address these concerns by providing education and recommendations about the importance of influenza vaccination during pregnancy.
Factors Influencing COVID-19 Vaccine Hesitancy in Pregnant and Breastfeeding/Puerperium Women: A Cross-Sectional Study
Authors: Comparcini Dania , Tomietto Marco , Pastore Francesco , Nichol Bethany , Miniscalco Daniela , Flacco Maria Elena , Stefanizzi Pasquale , Tafuri Silvio , Cicolini Giancarlo , Simonetti Valentina
Published: July 2024

Vaccination among pregnant and breastfeeding women is critical for protecting this vulnerable population and their children. COVID-19 vaccination is recommended both during pregnancy and breastfeeding; however, we still do not fully understand the determinants that influence hesitancy towards COVID-19 vaccination. This study aimed to identify the determinants of vaccine hesitancy in pregnant and breastfeeding, puerperium women. A multicenter, cross-sectional study, involving 435 pregnant and breastfeeding women, was conducted. Vaccination hesitancy was evaluated by administering the Vaccination Attitudes (VAX) Scale and the Zung Anxiety Self-Assessment Scale (SAS) was adopted to measure anxiety levels. Overall, 14% of the participants reported that they did not receive the COVID-19 vaccine, and 78.3% received their first dose during pregnancy or while breastfeeding. The descriptive statistics for the VAX scale showed a total mean score of 3.35 (±1.6), and 75% of participants reported an anxiety index equal to or lower than the threshold. Vaccine hesitancy increased as “adverse events after vaccination” increased (p < 0.01), while SAS levels positively correlated with the participants’ mean age (p < 0.05). Investigating the factors influencing vaccine hesitancy enables the development of targeted health policies and SARS-CoV-2 vaccination programs.
Capturing the Value of Vaccination within Health Technology Assessment and Health Economics—Practical Considerations for Expanding Valuation by Including Key Concepts
Authors: Biundo Eliana , Dronova Mariia , Chicoye Annie , Cookson Richard , Devlin Nancy , Doherty T. Mark , Garcia Stephanie , Garcia-Ruiz Antonio J. , Garrison Louis P. , Nolan Terry , Postma Maarten , Salisbury David , Shah Hiral , Sheikh Shazia , Smith Richard , Toumi Mondher , Wasem Jurgen , Beck Ekkehard
Published: July 2024

Following the development of a value of vaccination (VoV) framework for health technology assessment/cost-effectiveness analysis (HTA/CEA), and identification of three vaccination benefits for near-term inclusion in HTA/CEA, this final paper provides decision makers with methods and examples to consider benefits of health systems strengthening (HSS), equity, and macroeconomic gains. Expert working groups, targeted literature reviews, and case studies were used. Opportunity cost methods were applied for HSS benefits of rotavirus vaccination. Vaccination, with HSS benefits included, reduced the incremental cost-effectiveness ratio (ICER) by 1.4–50.5% (to GBP 11,552–GBP 23,016) depending on alternative conditions considered. Distributional CEA was applied for health equity benefits of meningococcal vaccination. Nearly 80% of prevented cases were among the three most deprived groups. Vaccination, with equity benefits included, reduced the ICER by 22–56% (to GBP 7014–GBP 12,460), depending on equity parameters. Macroeconomic models may inform HTA deliberative processes (e.g., disease impact on the labour force and the wider economy), or macroeconomic outcomes may be assessed for individuals in CEAs (e.g., impact on non-health consumption, leisure time, and income). These case studies show how to assess broader vaccination benefits in current HTA/CEA, providing decision makers with more accurate and complete VoV assessments. More work is needed to refine inputs and methods, especially for macroeconomic gains.
Systemic and Mucosal Immunogenicity of Monovalent XBB.1.5-Adapted COVID-19 mRNA Vaccines in Patients with Inflammatory Bowel Disease
Authors: Woelfel Simon , Dütschler Joel , Junker Daniel , König Marius , Leinenkugel Georg , Graf Nicole , Krieger Claudia , Truniger Samuel , Franke Annett , Koller Seraina , Metzger-Peter Katline , Oberholzer Melanie , Frei Nicola , Geissler Nora , Schaub Peter ,   STAR SIGN Investigators, Albrich Werner C. , Friedrich Matthias , Niess Jan Hendrik , Schneiderhan-Marra Nicole , Dulovic Alex , Korte Wolfgang , Bürgi Justus J. , Brand Stephan
Published: July 2024

Recently updated COVID-19 mRNA vaccines encode the spike protein of the omicron subvariant XBB.1.5 and are recommended for patients with inflammatory bowel disease (IBD) on immunosuppressive treatment. Nonetheless, their immunogenicity in patients with IBD against rapidly expanding virus variants remains unknown. This prospective multicenter cohort study is the first study to investigate the immunogenicity of XBB.1.5-adapted vaccines in patients with IBD. Systemic and mucosal antibodies targeting the receptor-binding domains (RBDs) of the omicron subvariants XBB.1.5, EG.5.1, and BA.2.86, as well as their neutralization were quantified before and two to four weeks after vaccination with monovalent XBB.1.5-adapted mRNA vaccines. Vaccination increased levels of serum anti-RBD IgG targeting XBB.1.5, EG.5.1, and BA.2.86 (1.9-fold, 1.8-fold, and 2.6-fold, respectively) and enhanced corresponding neutralization responses (2.3-fold, 3.1-fold, and 3.5-fold, respectively). Following vaccination, anti-TNF-treated patients had reduced virus neutralization compared to patients on treatments with other cellular targets. 11.1% and 16.7% of patients lacked EG.5.1 and BA.2.86 neutralization, respectively; all these patients received anti-TNF treatment. At mucosal sites, vaccination induced variant-specific anti-RBD IgG but failed to induce RBD-targeting IgA. Our findings provide a basis for future vaccine recommendations while highlighting the importance of frequent booster vaccine adaptation and the need for mucosal vaccination strategies in patients with IBD.
Therapeutic Anti-Tumor Efficacy of DC-Based Vaccines Targeting TME-Associated Antigens Is Improved When Combined with a Chemokine-Modulating Regimen and/or Anti-PD-L1
Authors: Taylor Jennifer L. , Kokolus Kathleen M. , Basse Per H. , Filderman Jessica N. , Cosgrove Chloe E. , Watkins Simon C. , Gambotto Andrea , Lowe Devin B. , Edwards Robert P. , Kalinski Pawel , Storkus Walter J.
Published: July 2024

We previously reported that dendritic cell (DC)-based vaccines targeting antigens expressed by tumor-associated vascular endothelial cells (VECs) and pericytes effectively control tumor growth in translational mouse tumor models. In the current report, we examined whether the therapeutic benefits of such tumor blood vessel antigen (TBVA)-targeted vaccines could be improved by the cotargeting of tumor antigens in the s.c. B16 melanoma model. We also evaluated whether combination vaccines incorporating anti-PD-L1 checkpoint blockade and/or a chemokine-modulating (CKM; IFNα + TLR3-L [rintatolimod] + Celecoxib) regimen would improve T cell infiltration/functionality in tumors yielding enhanced treatment benefits. We report that DC–peptide or DC–tumor lysate vaccines coordinately targeting melanoma antigens and TBVAs were effective in slowing B16 growth in vivo and extending survival, with superior outcomes observed for DC–peptide-based vaccines. Peptide-based vaccines that selectively target either melanoma antigens or TBVAs elicited a CD8+ T cell repertoire recognizing both tumor cells and tumor-associated VECs and pericytes in vitro, consistent with a treatment-induced epitope spreading mechanism. Notably, combination vaccines including anti-PD-L1 + CKM yielded superior therapeutic effects on tumor growth and animal survival, in association with the potentiation of polyfunctional CD8+ T cell reactivity against both tumor cells and tumor-associated vascular cells and a pro-inflammatory TME.
2DH Numerical Study of Solitary Wave Processes around an Idealized Reef-Fringed Island
Authors: Liu Weijie , Qian Feng , Ning Yue , Cheng Rongliang
Published: July 2024

In order to better understand the role of coral reefs around an isolated island in mitigating tsunami hazards, this study performed a horizontally two-dimensional (2DH) numerical study of tsunami-like solitary wave propagation and run-up around an idealized reef-fringed island. The shock-capturing Boussinesq wave model, the FUNWAVE-TVD is used in the present study and well-validated with existing experimental data for its robustness in predicting 2DH solitary wave processes around an island. Based on the validated model, the typical solitary propagation process around the reef-fringed island and the effects of morphological and hydrodynamic parameters on the maximum run-up heights were systematically investigated. It is found that coral reefs can effectively reduce maximum run-up heights around an isolated island. The reef flat’s water depth, reef flat width, and reef surface roughness are the main factors affecting maximum run-up heights around an island, while the fore-reef slope has little impact. For the idealized reef-fringed island in this study, sea-level rise will cause coral reefs to lose their protective capability on the lee side, and the presence of coral reefs may even enhance tsunami hazards around an island when the reef flat width is very narrow or coral bleaching happens.
Unraveling the Potential of Microbial Flocculants: Preparation, Performance, and Applications in Wastewater Treatment
Authors: Yang Yang , Jiang Cancan , Wang Xu , Fan Lijing , Xie Yawen , Wang Danhua , Yang Tiancheng , Peng Jiang , Zhang Xinyuan , Zhuang Xuliang
Published: July 2024

Microbial flocculants (MBFs), a class of eco-friendly and biodegradable biopolymers produced by various microorganisms, have gained increasing attention as promising alternatives to conventional chemical flocculants in wastewater treatment and pollutant removal. This review presents a comprehensive overview of the current state of MBF research, encompassing their diverse sources (bacteria, fungi, and algae), major categories (polysaccharides, proteins, and glycoproteins), production processes, and flocculation performance and mechanisms. The wide-ranging applications of MBFs in removing suspended solids, heavy metals, dyes, and other pollutants from industrial and municipal wastewater are critically examined, highlighting their superior efficiency, selectivity, and environmental compatibility compared to traditional flocculants. Nonetheless, bioflocculants face significant challenges including high substrate costs, low production yields, and intricate purification methodologies, factors that impede their industrial scalability. Moreover, the risk of microbial contamination and the attendant health implications associated with the use of microbial flocculants (MBFs) necessitate thorough evaluation. To address the challenges of high production costs and variable product quality, strategies such as waste valorization, strain improvement, process optimization, and biosafety evaluation are discussed. Moreover, the development of multifunctional MBF-based flocculants and their synergistic use with other treatment technologies are identified as emerging trends for enhanced wastewater treatment and resource recovery. Future research directions are outlined, emphasizing the need for in-depth mechanistic studies, advanced characterization techniques, pilot-scale demonstrations to accelerate the industrial adoption of MBF, and moreover, integration with novel wastewater treatment processes, such as partial nitrification and the anammox process. This review is intended to inspire and guide further research and development efforts aimed at unlocking the full potential of MBFs as sustainable, high-performance, and cost-effective bioflocculants for addressing the escalating challenges in wastewater management and environmental conservation.
Responses of Soil Moisture to Gully Land Consolidation in Asian Areas with Monsoon Climate
Authors: Lin Mingyi , Zhang Jing , Cao Guofan , Han Hao , Jin Zhao , Luo Da , Zeng Guang
Published: July 2024

Groundwater resources are essential for sustaining ecosystems and human activities, especially under the pressures of climate change. This study employed Electrical Resistivity Tomography (ERT) to assess the impact of Gully Land Consolidation (GLC) engineering on the groundwater hydrological field of small watersheds in the China Loess Plateau (CLP). Results revealed ample subsurface water storage in backfilled areas, primarily migrating along the original river path owing to topographical limitations. Although the distribution patterns of soil moisture in each backfilling block varied slightly, the boundaries of soil moisture content and variation mainly appeared at depths of 8 m and 20 m underground. Significant moisture variation occurred across the 0–20 m underground layers, suggesting the 8–20 m layer could function as a groundwater collection zone in the study area. Human activities could disturb groundwater, altering migration pathways from the original river path. An optimized “Drainage–Conveyance–Barrier” system is proposed to enhance GLC sustainability, involving upstream groundwater level control, midstream soil moisture management, and downstream hydrological connectivity improvement. These findings carry substantial implications for guiding the planning and execution of GLC engineering initiatives. The novelty of this study lies in its application of ERT to provide a detailed spatial and temporal understanding of soil moisture dynamics in the GLC areas. Future research should focus on factors such as soil types and topographical changes for a comprehensive assessment of GLC’s impact on small watershed groundwater hydrology.
Removal of Nitrogen and Phosphorus in Low Polluted Wastewater by Aquatic Plants: Impact of Monochromatic Light Radiation
Authors: Fan Lingyun , Zhang Xujia , Li Qi , Liu Yi , Wang Hanxi , Zang Shuying
Published: July 2024

Plant absorption via aquatic plants is vital for the deep purification of treated wastewater. This study aimed to determine the removal efficiencies of nitrogen and phosphorus for different aquatic plants and the effect of monochromatic light as compared to white light. Five plants (i.e., Iris pseudacorus, Oenanthe javanica, Zantedeschia aethiopica, Ipomoea aquatica Forssk. and Sagittaria trifolia) were cultured in prepared wastewater and radiated by white, red, green and blue LED lamps with 8 h radiation per day, respectively. After 4 d of cultivation, the O. javanica and S. trifolia exhibited relatively better growth status and higher TP removal rates (90%). The blue light radiation played a key role in the TP uptake of the tested plants. The N removal rates of plants were relatively lower (10–40%), limited by the low COD content. The S. trifolia exhibited the highest efficiency, and red light promoted the removal of TN and NO3−-N, whereas NH4+-N removal was driven by blue light radiation. So, O. javanica and S. trifolia coupled with blue and red lamps as supplementary light were suggested for the deep purification of municipal treated wastewater. The effect of intensity and ratio of monochromatic lights could be a direction for further research.
Evaluation and Comparison of Five Long-Term Precipitation Datasets in the Hang-Jia-Hu Plain of Eastern China
Authors: Wang Kunxin , Qiang Yaohui , Nie Wei , Gou Peng , Wang Feng , Liu Yang , Zhang Xuepeng , Zhou Tianyu , Wang Siyu
Published: July 2024

This study analyzed the applicability of five long-term precipitation datasets in the Hang-Jia-Hu Plain of eastern China based on meteorological observation data. The accuracy of each dataset at different time scales (yearly, monthly) was analyzed. Besides, their spatiotemporal distributions and differences in precipitation event frequency were also compared. The results indicate that the high-resolution (1 day, 1 km) and long-term (1961–2019) gridded dataset for temperature and precipitation across China (HRLT) exhibited the best overall performance at the annual scale, while the long-term, gauge-based gridded precipitation dataset for the Chinese mainland (CHM_PRE) performed the best at the monthly scale. The dataset of monthly precipitation with a resolution of 1 km in China from 1960 to 2020 (HHU) and the China Meteorological Forcing Dataset (CMFD) tend to overestimate the local precipitation amounts, while the other three products are characterized by an underestimation. The mean result of the five datasets indicates a slight, statistically insignificant rise in precipitation, by 4.19 mm annually, with an overall multi-year average of 1303.28 mm. The analysis of the five datasets successfully captures the spatial precipitation patterns across the Hang-Jia-Hu Plain, characterized by higher precipitation levels in the southwest and lower in the northeast. Although the interannual variability displays general consistency, there are significant discrepancies in the interannual growth rates and the spatial distribution of significance across different regions. This study can provide a reference for the accuracy of precipitation data in the fields of hydrology, meteorology, agriculture, and ecology, facilitating the analysis of uncertainties in related research.
Agricultural Drought-Triggering for Anticipatory Action in Papua New Guinea
Authors: Isaev Erkin , Yuave Nathan , Inape Kasis , Jones Catherine , Dawa Lazarus , Sidle Roy C.
Published: July 2024

Throughout its history, Papua New Guinea (PNG) has faced recurrent agricultural droughts, imposing considerable strain on both livelihoods and the economy. Particularly severe droughts have been associated with El Niño climate patterns. During these episodes, PNG becomes especially vulnerable to extended periods of aridity and diminished precipitation. Historically, humanitarian assistance for these events has primarily focused on responding to emergencies after an agricultural drought has been declared and communities have already been impacted. Here, we developed a proactive agricultural drought-triggering method for anticipatory action (AA) in PNG to offer a more sustainable and cost-effective approach to address this hazard. Our AA uses weather forecasts and risk data to identify and implement mitigative actions before a disaster occurs. The research details a step-by-step guide from early warning to action implemented by the Food and Agricultural Organization of the United Nations and the Government of Papua New Guinea. This preemptive disaster risk management initiative integrates a combined drought index (CDI) with specific thresholds and tailored anticipatory actions based on crop calendars. Moreover, the developed CDI provides a 3-month lead time for implementing AA to reduce the impact of the agricultural drought. During the El Niño-induced drought event that began in 2023, the CDI was tested and the AA was piloted for the first time.
CCBA-NMS-YD: A Vehicle Pedestrian Detection and Tracking Method Based on Improved YOLOv7 and DeepSort
Authors: Yuan Zhenhao , Wang Zhiwen , Zhang Ruonan
Published: July 2024

In this paper, we propose a vehicle pedestrian detection and tracking method based on the improved YOLOv7 and DeepSort algorithms. We aim to improve the quality of vehicle pedestrian detection and tracking, addressing the challenges that current commercially available autonomous driving technologies face in complex and changing road traffic situations. First, the NMS (non-maximum suppression) algorithm in YOLOv7 is replaced with a modified Soft-NMS algorithm to ensure that targets can be accurately detected at high densities, and second, the CCBA (coordinate channel attention module) attention mechanism is incorporated to improve the feature extraction and perception capabilities of the network. Finally, a multi-scale feature network is introduced to extract features of small targets more accurately. Finally, the MobileNetV3 lightweight module is introduced into the feature extraction network of DeepSort, which not only reduces the number of model parameters and network complexity, but also improves the tracking performance of the target. The experimental results show that the improved YOLOv7 algorithm improves the average detection accuracy by 3.77% compared to that of the original algorithm; on the MOT20 dataset, the refined DeepSort model achieves a 1.6% increase in MOTA and a 1.9% improvement in MOTP; in addition, the model volume is one-eighth of the original algorithm. In summary, our model is able to achieve the desired real-time and accuracy, which is more suitable for autonomous driving.
MENTAL HEALTH APPLICATION PROTOTYPE WITH MACHINE LEARNING AND AUGMENTED REALITY APPLICATION DURING THE COVID-19 PANDEMIC
Authors: Saputra Royan Dwi , Agusty Mella Aulia , Hanifah Jihan , Rezkyandar Muhammad , Inda Septa , Abdiansah
Published: July 2024

The Covid-19 pandemic has impacted all aspects of human life, regardless of the impact on mental health. Mental health is an essential issue because many people experience mental health problems, but they are appropriately not resolved. There are many methods in solving mental health problems, but not all of them can reach people due to distance, time, and costs. This study aims to explain the findings regarding an application made to minimize problems, maintain, and improve the mental health of an application called Soodo. The method used in this research is descriptive quantitative. From the findings of this study, this application can help to maintain and improve people's mental health. The results from system user testing (SUS) showed a satisfactory assessment of the Soodo application. From the results of calculations using the (SUS) method, the statistical results of the evaluation of the Soodo application prototype are Excellent or at grade A.
DESIGN AND DEVELOPMENT OF ACCOUNTING INFORMATION SYSTEM FOR CASH SALES OF MILD STEEL
Authors: Puspita Ari , Yuningsih Yuyun , Fahmi Muhammad , Yunandar Rahmat Tri
Published: July 2024

Abstract
Technological developments are now experiencing rapid growth, so many entrepreneurs compete to produce new companies. At this time, the light steel business is multiplying. The researcher tries to research the weak steel sales system. Most companies do not have a computerized recording system, so inputting invoices is hampered. Sales notes are written manually to report generation, so that it will take a long time. In making the information system, the author will use the waterfall model and will use the PHP programming language for the manufacture of this software. The purpose of making this sales information system is to make it easier to carry out a mild steel sales system to shorten processing time and minimize all forms of errors in reporting.
Pediatric Endonasal Endoscopic Dacryocystorhinostomy: Own Experience
Authors: Бабаханов Г.К.
Published: July 2024

Дакриоцисториностомия – создание функциональной анормальной фистулы (стомы) из слезного мешка в средний носовой ход при дакриоциститах посредством остеотомии костей слезной ямки (fossa sacci lacrimalis). Ее можно проводить наружным или эндоназальным доступом. Эндоназальный хирургический подход у детей с дакриоциститами отличается от такового у взрослых. Нами разработаны показания и противопоказания к проведению операции, так как с 1986 г. по сей день в нашей клинике произведено более 400 эндоназальных дакриоцисториностомий у детей. Цель работы – оповестить о показаниях, противопоказаниях и эффективности эндоназальной эндоскопической дакриоцисториностомии у детей. Анализ результатов показал, что следование определенным показаниям, противопоказаниям и рекомендуемой технике оториноларингологической эндоназальной эндоскопической дакриоцисториностомии у детей способствует эффективному (98%) и безопасному лечению детей с хроническими дакриоциститами и даже осложненной флегмоной слезного мешка при низкой частоте осложнений.

Dacryocystorhinostomy is a creation of a functional abnormal fistula (stoma) from the lacrimal sac into the middle nasal meatus in dacryocystitis, through osteotomy of the bones of the lacrimal fossa (fossa sacci lacrimalis). It can be performed externally or endonasally. The endonasal surgical approach in children with dacryocystitis differs from that in adults. We have established indications and contraindications for the operation, because from 1986 to the present day, our clinic has performed more than 400 endonasal dacryocystorhinostomies in children. Purpose of the work – to provide information about indications, contraindications and effectiveness of endonasal endoscopic dacryocystorhinostomy in children. The analysis of the results revealed that following our indications, contraindications and recommended techniques for otorhinolaryngological endonasal endoscopic dacryocystorhinostomy in children contributes to effective (98%) and safe treatment of children with chronic dacryocystitis and even with complicated phlegmon of the lacrimal sac along with low complication rate.
SUTURE MATERIAL WITH ANTIBACTERIAL COATING IN SMALL AND LARGE INTESTINE RESECTION
Authors: Скальская Н. Т. ,   Surgut District Clinical Hospital, Surgut, Russia, Дарвин В. В. ,   Surgut State University, Surgut, Russia
Published: July 2024

The study reviewed the scientific literature available on the CyberLeninka and eLIBRARY.RU electronic scientific libraries, as well as the PubMed database. The study focused on the use of suture material with antibacterial triclosan coating for small and large intestine resection; the reduction of the risk of surgical site infection during small and large intestine resection; the feasibility of using antibiotic therapy and the validity of combining the latter with systemic antibacterial therapy; and the prospects of developing a biologically active suture material.
FINDINGS OF THE RUSSIAN PRACTICING PHLEBOLOGISTS' SURVEY ON THE CHALLENGES OF TREATING THE VENOUS TROPHIC ULCERS: CLINICAL PRACTICE
Authors: Новицкая К. С. ,   Surgut State University, Surgut, Russia, Маркин С. М. ,   Phlebology Center of the Clinical Hospital of the Russian Academy of Sciences, St. Petersburg, Russia
Published: July 2024

The study presents the findings of the survey conducted among 152 practicing phlebologists, members of the Russian Phlebological Association. The survey focused on the challenges in determining etiology of trophic ulcers, which over 74 % of surgeons encounter in their practice, and their treatment; shave-therapy and the issues of its application; and the evaluation of the prospects of using shave-therapy as the most efficient treatment method in surgical practice.
PENGGUNAAN METODE ROLE PLAYING UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS VI SD NEGERI 38 PADA PEMBELAJARAN IPS TENTANG DAMPAK GLOBALISASI
Authors: Said Ishak
Published: July 2024

ABSTRAK
Latar belakang masalah dalam penelitian tindakan kelas ini adalah siswa belum aktif karena guru masih banyak menggunakan metode konvensional berupa ceramah, sehingga hasil belajar IPS siswa kelas VI SD Negeri 38 Pangkalpinang, belum mencapai nilai ketuntasan yang optimal. Masalah yang dirumuskan sebagai berikut: â€œApakah dengan penggunaan Metode Pembelajaran Role Playing  dapat meningkatkan hasil belajar IPS tentang Dampak Globalisasi pada siswa kelas VI SD Negeri 38 Pangkalpinang?â€.
Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Model PTK menggunakan 2 siklus, masing-masing siklus terdiri dari 4 tahap yakni 1) perencanaan tindakan (planning), 2) pelaksanaan tindakan (action) dan 3) pengamatan (observation), dan 4) refleksi (reflection). Subyek penelitian adalah siswa kelas VI SD Negeri 38 Pangkalpinang  sebanyak 23 siswa. Teknik pengumpulan data adalah teknik tes dan teknik observasi. Adapun instrumen penelitiannya dengan menggunakan butir-butir soal dan lembar observasi. Teknik analisis yang digunakan adalah deskriptif komparatif yang meliputi perbandingan mean, dan persentase.
Hasil penelitian ini menunjukkan peningkatan hasil belajar IPS siswa tentang dampak globalisasi, setelah menggunakan metode pembelajaran role playing. Hal ini nampak pada perbandingan nilai rata-rata yakni pada kondisi pra siklus sebesar 60, sedangkan pada siklus 1 naik menjadi 65 dan pada siklus 2 meningkat lagi menjadi 70. Adapun skor kreativitas belajar klasikal pada kondisi pra siklus 55 %; siklus I meningkat naik menjadi 75% dan pada siklus II meningkat naik menjadi 85%.
Kata Kunci : Metode,Role Playing dan Hasil Belajar
Penerapan Model Pembelajaran Kooperatif Tipe STAD untuk Meningkatkan Hasil Belajar Matematika Di Kelas V SD Negeri 1 Windunegara, Kabupaten Banyumas
Authors: Hoziyana Greffi , Muryaningsih Sri
Published: July 2024

Penelitian ini dilatar belakangi oleh rendahnya hasil belajar peserta didik dikelas V SDN 1 Windunegara. Penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik pada mata pelajaran matematika materi sifat-sifat bangun ruang melalui model pembelajaran kooperatif tipe STAD. Penelitian ini merupakan jenis Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam dua siklus. Subjek penelitian ini yaitu peserta didik kelas V SDN 1 Windunegara dengan jumlah peserta didik 22 yang terdiri dari 12 peserta didik laki-laki dan 10 peserta didik perempuan. Hasil penelitian menunjukan adanya peningkatan dari hasil belajar peserta didik. Hasil belajar peserta didik pada aspek afektif siklus I memperoleh presentase siklus yaitu 53,26% dengan kriteria kurang. Pada siklus II memperoleh presentase siklus yaitu 83,35% dengan kriteria sangat baik. Hasil belajar peserta didik pada aspek kognitif pada siklus I memperoleh presentase ketuntasan 79,47% dengan kriteria baik. Pada siklus II memperoleh presentase ketuntasan 82,50% dengan kriteria sangat baik. Hasil belajar peserta didik pada aspek psikomotor pada siklus I memperoleh presentase ketuntasan 78,75% dengan kriteria baik. Pada siklus II memperoleh presentase ketuntasan 96,25% dengan kriteria sangat baik. Hasil tersebut menunjukan bahwa pembelajaran melalui model pembelajaran kooperatif tipe STAD dapat meningkatkan hasil belajar matematika pada materi sifat-sifat bangun ruang di kelas V SDN 1 Windunegara.
Validitas dan Reliabilitas Instrumen Penilaian Berbasis Respon Perilaku untuk Mengukur Keterampilan Membaca Siswa Kelas Tinggi Sekolah Dasar Negeri Pongtiku II Makassar
Authors: Aminah Nur Aminah Radjab , Akib Erwin , Arief Tarman A.
Published: July 2024

Penelitian ini bertujuan untuk menguji validitas dan realibilitas  instrumen penilaian berbasis respon perilaku untuk mengukur keterampilan membaca siswa kelas tinggi di SDN Pongtiku II Makassar. Jenis penelitian ini adalah penelitian pengembangan. Teknik pengumpulan data kualitatif dilakukan melalui observasi dan data kuantitatif melalui pengisian angket.  Hasil penelitian menunjukkan (1) Berdasarkan hasil analisa kelayakan “Instrumen penilaian berbasis respon  perilaku untuk mengukur keterampilan membaca siswa kelas tinggi” ini   dinyatakan layak untuk digunakan, dengan perolehan validasi ahli sebesar 95%  untuk aspek kelayakan isi, 95% untuk aspek kelayakan penyajian,  95% untuk aspek kelayakan kebahasaan dan 95% untuk aspek penilaian kontekstual, dengan kategori secara keseluruhan Sangat Layak; dan (3) Berdasarkan hasil analisa keefektifan “Instrumen penilaian berbasis respon  perilaku untuk mengukur keterampilan membaca siswa kelas tinggi” ini dinyatakan cukup efektif yang dilakukan pada 92 siswa meski terdapat beberapa siswa  yang mengajukan pertanyaan terkait butir item tertentu, namun dapat dituntaskan.
UPAYA MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR PESERTA DIDIK MUATAN PELAJARAN PPKN MELALUI MODEL PROBLEM BASED LEARNING BERBANTUAN MEDIA E-EDUMAGZ DI KELAS III SD NEGERI CIMANGGU 01
Authors: Shabrina Salsa , Nugroho Agung
Published: July 2024

This classroom action research is motivated by students' low motivation and academic achievement in Civics Education learning in Grade III of SD NEGERI CIMANGGU 01 (Cimanggu 01 Public Elementary School). This research aims to solve students' low motivation and academic achievement through the application of PBL strategies assisted by E-Edumagz (Electronic Educational Magazine) media in Civics Education learning in Grade III of Cimanggu 01 Elementary School. This research was conducted in two cycles, each consisting of two meetings. The research subjects were 24 students in Grade III. The data were collected using observation sheets, evaluation sheets, questionnaires, and documentation. The results of this study show a gradual increase in student motivation and academic achievement. In the first cycle, academic achievement yielded an average score of 76.5 with a completion rate of 64.58% (rated as fair), which subsequently improved in the second cycle to an average score of 84.5, accompanied by a completion rate of 85.4% (rated as good). Similarly, in the first cycle, learning motivation reached a completion rate of 74.24% (rated as fair), and this increased in the second cycle to a completion rate of 80.86% (rated as good). The use of PBL strategies assisted by E-Edumagz (Electronic Educational Magazine) media has positively impacted student motivation and academic achievement in accordance with the expected success indicators.
Pengaruh Media Pembelajaran Holo Math terhadap Hasil Belajar pada Matematika Peserta Didik SD Inpres 40 Matawolot
Authors: Kusuma Hadi Satria
Published: July 2024

ABSTRAK
Satria  Kusuma Hadi  /148620617091.  PENGARUH MEDIA PEMBELAJARAN HOLO MATH (HOLOGRAM MATHEMATIC) TERHADAP HASIL BELAJAR MATEMATIKA PADA MATERI BILANGAN BULAT KELAS VI SD INPRES 40 KABUPATEN SORONG. Skripsi. Fakultas Keguruan dan Ilmu Pendidikan Universitas Pendidikan Muhammadiyah Sorong. Desember 2023
Penelitian ini bertujuan untuk untuk mengetahui Pengaruh media pembelajaran holo math (Hologram Matematic)terhadap hasil belajar matematika pada materi bilangan bulat kelas VI SD Inpres 40 Kabupaten Sorong . Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif  dengan jenis  Pre-Exsperimental atau Pra Eksperimen. Teknik pengumpulan data menggunakan teknik observasi, pembagian lembar angket, menggunakan soal post test pre test, dan dokumentasi. Teknik analisis data yang digunakan adalah menggunakan analisis deskriptif kuantitatif. Menganalisis data dengan cara mendeskripsikan atau mengambarkan data yang telah terkumpul sebagaimana adanya tanpa maksud membuat kesimpulan yang berlaku untuk umum atau genaralisasi. Pada penelitian ini juga dilakukan uji normalitas yang mengggunakan uji Kolmogrov-Smirnov untuk mengetahui persebaran data yang dilakukan normal atau tidak. Kesimpulannya Aktivitas belajar peserta didik yang yang diajarkan dengan menggunakan media holo math lebih baik dibandingkan dengan tidak menggunakan media.mereka lebih mudah memahami  matematika dengan materi yang disugukan bilangan bulat. Hal ini dapat dilihat dari hasil presentase rata-rata kedua pengamat yang dilakukan sebelum diberi tindakan dan sesudah diberi tindakan yang tertera pada hasil SPSS V23.0 nilai singnifikansi 0,153 dan vidio holo math termasuk dalam kategori baik, berdasarkan hasil observasi dan angket yang dibagikan pada peserta didik. Adapun nilai post tes dan pre test yang menunjukkan bahwa setelah di beri tindakan terdapat perubahan yang signifikan.
Contextual Learning Through Cooperative Design Assisted by Vocal Media on Traditional Musical Instruments of Bangka Belitung as an Effort to Increase Student Learning Activity at SD STKIP Muhammadiyah Bangka Belitung
Authors: Cemara Dodi Pranata
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran alat musik tradisional gendang anak dan gendang induk terhadap kreativitas anak menggunakan media vokal pada kelas IV SD STKIP Muhammadiyah Bangka Belitung. Penelitian ini termasuk penelitian tindakan kelas (PTK) yang dilaksanakan pada tahap perencanaan, pelaksanaan, observasi, dan refleksi. Subyek penelitian ini adalah siswa kelas V SD STKIP Muhammadiyah Bangka Belitung. Penelitian ini menggunakan Teknik analisis data yang digunakan adalah reduksi data, penyajian data, penarikan kesimpulan, dan diskusi. Peningkatan aktivitas belajar siswa pada mata pelajaran Seni Budaya dan Prakarya dibuktikan dengan survei data yang dilakukan. Pada kondisi awal rata-rata aktivitas belajar siswa kategori siklus I dilakukan pada penerapan desain pembelajaran kooperatif berbasis media TGT atau vokal/solfegio pada materi alat musik tradisional. Hasil penelitian menunjukkan bahwa rata-rata keseluruhan siklus 1 setelah penerapan desain pembelajaran kooperatif berbantuan media vokal/solfegio TGT pada materi alat musik tradisional adalah 74,36 sehingga termasuk dalam kategori Baik. Pada siklus II diperoleh hasil rata-rata aktivitas belajar sebesar 88,00 atau termasuk dalam kategori sangat baik. Peningkatan aktivitas belajar meliputi delapan dimensi meliputi: visual, motorik, dan solfeggio. Hasil penelitian ini menunjukkan bahwa pembelajaran alat musik tradisional meningkatkan peningkatan aktivitas siswa secara signifikan. Temuan ini menunjukkan bahwa penggunaan alat musik tradisional yaitu gendang anak dan gendang induk sebagai media pembelajaran dapat menjadi strategi pembelajaran yang efektif dalam mengembangkan kreativitas anak di pendidikan dasar.
Türkiye'deki Üniversiteleşme Politikasının Bölgesel Ekonomik Kalkınma ve Büyüme Üzerindeki Etkisinin İncelenmesi
Authors: Demirdağ İsmail
Published: July 2024

Günümüzde, öğretim ve araştırma gibi akademik faaliyetlerin ötesine geçen üniversiteler, üçüncü bir misyon yüklenerek bölgesel kalkınmanın, büyümenin ve rekabetin kritik aktörleri olarak yaygın olarak kabul görmeye başlamıştır. Büyük çaplı istihdam sağlayıcıları ve hizmet alıcıları olan üniversiteler araştırma-geliştirme, yenilikler, teknolojik gelişmeler, mekânsal bilgi üretimi ve transferi, ağlar ve iş birliklerindeki rolleriyle bölge ekonomilerinin gelişmesine ve büyümesine kayda değer katkılar sunmaktadır. Her ile en az bir üniversite söylemiyle yola çıkılan hükümet
politikası sonucunda, 2008’den itibaren Türkiye’deki 81 NUTS-III bölgesinin tamamında en az bir üniversite kurulmuştur. Ancak kurulan üniversitelerin bütün bölgeler üzerindeki ekonomik etkisini ölçen çalışma sayısı yok denecek kadar azdır. 81 NUTS-III bölgesinin 1990-2020 dönemine ait geniş kapsamlı veri setini kullanan bu makale, Türkiye’deki üniversitelerin bölgesel ekonomik kalkınma düzeyi ve büyüme hızları üzerindeki etkisini incelemeye çalışmaktadır. Ayrıca, bu araştırma aynı dönem içinde üniversitelerin bölgelerarası yakınsamadaki rollerine de ışık tutmaya çalışmaktadır. Çalışma, ilk olarak Çoklu Regresyon Analizini kullanarak üniversiteyi temsil eden bağımsız değişkenler ile kişi başına düşen ortalama GSYH olarak ölçülen bölgesel kalkınma düzeyi arasındaki ilişkiyi test etmektedir. Daha sonra, bağımsız değişkenlerin 1990-2020 dönemi içindeki ortalama yıllık büyüme hızlarını kullanarak üniversitelerin bölgesel ekonomik büyüme hızı (GSYH büyüme hızı) üzerindeki etkilerini analiz etmektedir. Son olarak, Quadrant Analizini kullanan makale, Türkiye’deki 81 NUTS-III bölgesini dört farklı gelişme kategorisine ayırmakta ve MANOVA-ANOVA analiz yöntemleriyle üniversiteyi temsil eden faktörlerin gelişme kategorileri arasında nasıl farklılaştığını ortaya koymaktadır. Elde edilen bulgular, üniversitelerin bölgelerin ekonomik olarak kalkınmasında, büyümesinde ve yakınsamasında çok yönlü etkilere sahip olduğunu ortaya koymaktadır. Diğer bir ifadeyle, üniversiteler piyasada oluşturdukları talepler, sağladıkları beşerî sermaye, yaptıkları yenilikler, ürettikleri yeni bilgiler ve oluşturdukları çeşitli ağlarla bölgelerin yüksek kalkınma düzeyine ve büyüme performansına erişmesinde kritik birer araçtır.
Co przychodzi po końcu władzy symbolicznej?
Authors: Świrek Krzysztof
Published: July 2024

The question of symbolic power is taking on a special importance today, when the purely symbolic means of legitimisation of power are being transformed, weakened and replaced by new forms of governance that refer to economic and technical norms. Pierre Bourdieu’s account of symbolic power, so influential in contemporary sociology, equates its operation with symbolic violence. Contemporary societies are manifesting multiple symptoms of crisis in the structures of symbolic power — and this crisis is leading not to the easing of violence but to the emergence of new forms of suffering. A different theoretical portrayal of symbolic power is therefore needed, one that would explain what we are losing with the crisis and weakening of this power. This article presents such a take, which refers predominantly to Lacanian psychoanalysis. Its first section lays out the main problem and provides a short reconstruction of Pierre Bourdieu’s account. The second part presents the sources of the notion of symbolic power, in the works of the Durkheimian school and structuralism, while the third introduces the psychoanalytic account. The fourth tackles the crisis in symbolic power, the fifth — new forms of suffering in the new, “post-symbolic” social situation, and the last part offers a summary of the arguments by referring to the issue of the relationship between symbolic and post-symbolic power.