bluuebunny/crossref_metadata_2025 huggingface dataset:
High resolution Tibetan Plateau regional reanalysis 1961-present
Authors: Zhou Peifeng , Tang Jianping , Ma Mengnan , Ji Dabin , Shi Jiancheng
Published: May 2024

With the rapid global warming in recent decades, the Tibetan Plateau (TP) has suffered severe impacts, such as glacier retreat, glacial lake expansion, and permafrost degradation, which threaten the lives and properties of the local and downstream populations. Regional Reanalysis (RR) is vital for TP due to the limitations of observations. In this work, a 62-year (1961–2022) long atmospheric regional reanalysis with spatial resolution of 9 km (convective gray-zone scale) and temporal resolution of 1 hour over the TP (TPRR) was developed using the Weather Research and Forecasting (WRF) model, combined with re-initialization method, spectral nudging (SN), and several optimizations. TPRR is forced by ERA5 at hourly intervals. TPRR outperforms ERA5, realistically capturing climatological characteristics and seasonal variations of precipitation and T2m (air temperature at 2m above ground level). Moreover, TPRR better reproduces the frequency and intensity of precipitation, as well as the diurnal cycle of precipitation. This study also quantifies the wetting trend of 0.0071 mm/year over the TP amid global warming using TPRR.
Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy
Authors: Chin Wee Loong , Zemek Rachael M. , Tilsed Caitlin M. , Forrest Alistair R. R. , Fear Vanessa S. , Forbes Catherine , Boon Louis , Bosco Anthony , Guo Belinda B. , Millward Michael J. , Nowak Anna K. , Lake Richard A. , Lesterhuis W. Joost , Lassmann Timo
Published: May 2024

Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tumor RNA sequencing data in the context of treatment with ICB in murine models of AB1 mesothelioma and Renca renal cell cancer. We sequenced 144 bulk RNAseq samples from these two cancer types across 4 time points prior and after treatment with ICB. We also performed single-cell sequencing on 12 samples of AB1 and Renca tumors an hour before ICB administration. Our samples were equally distributed between responders and non-responders to treatment. Additionally, we sequenced AB1-HA mesothelioma tumors treated with two sample dissociation protocols to assess the impact of these protocols on the quality transcriptional information in our samples. These datasets provide time-course information to transcriptionally characterize the ICB response and provide detailed information at the single-cell level of the early tumor microenvironment prior to ICB therapy.
Comparing vitamin D receptor gene polymorphisms in rs11568820, rs7970314, rs4334089 between COVID-19 patients with mild and severe symptoms: a case control study
Authors: Mohammadifard Noushin , Sadeghian Ladan , Hassannejad Razieh , Khosravi Elham , Gharipour Mojgan , Karimi Simin , Hosseini Shidokht , Sepahifar Mahtab , Bahrami Ghazaleh , Haghighatdoost Fahimeh , Sarrafzadegan Nizal
Published: May 2024

The associations of vitamin D receptor (VDR)- single nucleotide polymorphisms (SNPs) with the symptoms of COVID-19 may vary between patients with different severities of COVID-19. Therefore, in the present study, we aim to compare VDR polymorphisms in severe and mild COVID-19 patients. In this study, a total number of 85 hospitalized patients and 91 mild/moderate patients with COVID-19 were recruited. SNPs in VDR genes were determined using ARMS and then confirmed by sanger sequencing. The mean (SD) age of participants in hospitalized and non-hospitalized group was 59.0 (12.4) and 47.8 (14.8) years, respectively. Almost 46% of participants in hospitalized and 48% of participant in non-hospitalized group were male. The frequency of TT genotype of SNP rs11568820 was significantly lower in hospitalized than non-hospitalized group (3.5% vs. 17.6%; P = 0.018). However, there was no significant differences between genotypes of SNPs rs7970314 and rs4334089 and also alleles frequencies in all SNPs of two groups. The genotype of rs11568820 SNP had an inverse association with hospitalization of patients with COVID-19 after adjustment for comorbidities [OR 0.18, 95% CI 0.04, 0.88; P = 0.034]. While, there was no relationship between genotypes of SNPs rs7970314 and rs4334089 and hospitalization. The TT genotype of rs11568820 plays protective role in sever COVID-19 and hospitalization. Further studies with a large sample size which consider various confounding factors are warranted to confirm our results.
Killing vector fields of locally rotationally symmetric Bianchi type V spacetime
Authors: Ahmad Shakeel , Hussain Tahir , Saqib Abdul Baseer , Farhan Muhammad , Farooq Muhammad
Published: May 2024

The classification of locally rotationally symmetric Bianchi type V spacetime based on its killing vector fields is presented in this paper using an algebraic method. In this approach, a Maple algorithm is employed to transform the Killing’s equations into a reduced evolutive form. Subsequently, the integration of the Killing’s equations is carried out subject to the constraints provided by the algorithm. The algorithm demonstrates that there exist fifteen distinct metrics that could potentially possess Killing vector fields. Upon solving the Killing equations for all fifteen metrics, it is observed that seven out of the fifteen metrics exclusively exhibit the minimum number of Killing vector fields. The remaining eight metrics admit a varying number of Killing vector fields, specifically 6, 7, or 10. The Kretschmann scalar has been computed for each of the obtained metrics, revealing that all of them possess a finite Kretschmann scalar and thus exhibit regular behavior.
Gentamicin loaded niosomes against intracellular uropathogenic Escherichia coli strains
Authors: Forte Jacopo , Maurizi Linda , Fabiano Maria Gioia , Conte Antonietta Lucia , Conte Maria Pia , Ammendolia Maria Grazia , D’Intino Eleonora , Catizone Angela , Gesualdi Luisa , Rinaldi Federica , Carafa Maria , Marianecci Carlotta , Longhi Catia
Published: May 2024

Urinary tract infections (UTIs) are the most common bacterial infections and uropathogenic Escherichia coli (UPEC) is the main etiological agent of UTIs. UPEC can persist in bladder cells protected by immunological defenses and antibiotics and intracellular behavior leads to difficulty in eradicating the infection. The aim of this paper is to design, prepare and characterize surfactant-based nanocarriers (niosomes) able to entrap antimicrobial drug and potentially to delivery and release antibiotics into UPEC-infected cells. In order to validate the proposed drug delivery system, gentamicin, was chosen as “active model drug” due to its poor cellular penetration. The niosomes physical–chemical characterization was performed combining different techniques: Dynamic Light Scattering Fluorescence Spectroscopy, Transmission Electron Microscopy. Empty and loaded niosomes were characterized in terms of size, ζ-potential, bilayer features and stability. Moreover, Gentamicin entrapped amount was evaluated, and the release study was also carried out. In addition, the effect of empty and loaded niosomes was studied on the invasion ability of UPEC strains in T24 bladder cell monolayers by Gentamicin Protection Assay and Confocal Microscopy. The observed decrease in UPEC invasion rate leads us to hypothesize a release of antibiotic from niosomes inside the cells. The optimization of the proposed drug delivery system could represent a promising strategy to significatively enhance the internalization of antimicrobial drugs.
Real-time data visualization of welding robot data and preparation for future of digital twin system
Authors: Magyar Péter , Hegedűs-Kuti János , Szőlősi József , Farkas Gábor
Published: May 2024

The application of industrial technologies is undergoing significant changes. Finding the level at which to use efficient cyberphysical systems is perhaps one of the most important technical preparatory tasks in implementing digital manufacturing. Welding technology systems are investigated, and a framework for capturing the data sets required for data-driven manufacturing is developed. To make full autonomy in a manufacturing environment meaningful, formerly isolated groups of equipment need to be organized into a production information system. In our research, a test system is created that can implement a digital virtual interface and achieve new levels of efficiency with a future digital twin system. In the discourse of the study, the technological parameters of welding test pieces were investigated, namely the available measurement data sets of current, and voltage data. In the summary section, most of the tasks and research directions are presented, which can be envisaged as a continuation of the present study. Our study will be followed by further research, already testing a complete digital twin system, thus reaching another milestone on the way to autonomous manufacturing.
RETRACTED ARTICLE: Study of defensive behavior of a venomous snake as a new approach to understand snakebite
Authors: Alves-Nunes João Miguel , Fellone Adriano , Almeida-Santos Selma Maria , de Medeiros Carlos Roberto , Sazima Ivan , Vuolo Marques Otavio Augusto
Published: May 2024

Snakebites affect millions of people worldwide. The majority of research and management about snakebites focus on venom and antivenom, with less attention given to snake ecology. The fundamental factor in snakebites is the snakes’ defensive biting behavior. Herein we examine the effects of environmental variables (temperature, time of day, and human stimulus) and biological variables (sex and body size) on the biting behavior of a medically significant pit viper species in Brazil, Bothrops jararaca (Viperidae), and associate it with the epidemiology of snakebites. Through experimental simulations of encounters between humans and snakes, we obtained behavioral models applicable to epidemiological situations in the State of São Paulo, Brazil. We found a significant overlap between behavioral, morphological, environmental, and epidemiological data. Variables that increase snakebites in epidemiological data also enhance the tendency of snakes to bite defensively, resulting in snakebites. We propose that snakebite incidents are influenced by environmental and morphological factors, affecting the behavior of snakes and the proportion of incidents. Thus, investigating behavior of snakes related to snakebite incidents is a valuable tool for a better understanding of the epidemiology of these events, helping the prediction and, thus, prevention of snakebites.
Ketamine-induced prevention of SD-associated late infarct progression in experimental ischemia
Authors: Zdunczyk A. , Schumm L. , Helgers S. O. A. , Nieminen-Kelhä M. , Bai X. , Major S. , Dreier J. P. , Hecht N. , Woitzik Johannes
Published: May 2024

Spreading depolarizations (SDs) occur frequently in patients with malignant hemispheric stroke. In animal-based experiments, SDs have been shown to cause secondary neuronal damage and infarct expansion during the initial period of infarct progression. In contrast, the influence of SDs during the delayed period is not well characterized yet. Here, we analyzed the impact of SDs in the delayed phase after cerebral ischemia and the potential protective effect of ketamine. Focal ischemia was induced by distal occlusion of the left middle cerebral artery in C57BL6/J mice. 24 h after occlusion, SDs were measured using electrocorticography and laser-speckle imaging in three different study groups: control group without SD induction, SD induction with potassium chloride, and SD induction with potassium chloride and ketamine administration. Infarct progression was evaluated by sequential MRI scans. 24 h after occlusion, we observed spontaneous SDs with a rate of 0.33 SDs/hour which increased during potassium chloride application (3.37 SDs/hour). The analysis of the neurovascular coupling revealed prolonged hypoemic and hyperemic responses in this group. Stroke volume increased even 24 h after stroke onset in the SD-group. Ketamine treatment caused a lesser pronounced hypoemic response and prevented infarct growth in the delayed phase after experimental ischemia. Induction of SDs with potassium chloride was significantly associated with stroke progression even 24 h after stroke onset. Therefore, SD might be a significant contributor to delayed stroke progression. Ketamine might be a possible drug to prevent SD-induced delayed stroke progression.
Multi-attention fusion transformer for single-image super-resolution
Authors: Li Guanxing , Cui Zhaotong , Li Meng , Han Yu , Li Tianping
Published: May 2024

Recently, Transformer-based methods have gained prominence in image super-resolution (SR) tasks, addressing the challenge of long-range dependence through the incorporation of cross-layer connectivity and local attention mechanisms. However, the analysis of these networks using local attribution maps has revealed significant limitations in leveraging the spatial extent of input information. To unlock the inherent potential of Transformer in image SR, we propose the Multi-Attention Fusion Transformer (MAFT), a novel model designed to integrate multiple attention mechanisms with the objective of expanding the number and range of pixels activated during image reconstruction. This integration enhances the effective utilization of input information space. At the core of our model lies the Multi-attention Adaptive Integration Groups, which facilitate the transition from dense local attention to sparse global attention through the introduction of Local Attention Aggregation and Global Attention Aggregation blocks with alternating connections, effectively broadening the network's receptive field. The effectiveness of our proposed algorithm has been validated through comprehensive quantitative and qualitative evaluation experiments conducted on benchmark datasets. Compared to state-of-the-art methods (e.g. HAT), the proposed MAFT achieves 0.09 dB gains on Urban100 dataset for × 4 SR task while containing 32.55% and 38.01% fewer parameters and FLOPs, respectively.
Storage conditions affect the composition of the lyophilized secretome of multipotent mesenchymal stromal cells
Authors: Rogulska Olena , Vackova Irena , Prazak Simon , Turnovcova Karolina , Kubinova Sarka , Bacakova Lucie , Jendelova Pavla , Petrenko Yuriy
Published: May 2024

The widespread use of multipotent mesenchymal stromal cell-derived secretome (MSC-sec) requires optimal preservation methods. Lyophilization offers benefits like concentrating the secretome, reducing the storage volume, and making storage conditions more flexible. This study evaluated the influence of storage duration and temperature on lyophilized MSC-sec. The conditioned medium from Wharton’s jelly MSCs was stored at – 80 °C or lyophilized with or without trehalose. Lyophilized formulations were kept at – 80 °C, − 20 °C, 4 °C, or room temperature (RT) for 3 and 30 months. After storage and reconstitution, the levels of growth factors and cytokines were assessed using multiplex assay. The storage of lyophilized MSC-sec at – 80 °C ensured biomolecule preservation for 3 and 30 months. Following 3 month storage at 4 °C and RT, a notable decrease occurred in BDNF, bNGF, and sVCAM-1 levels. Prolonged 30 month storage at the same temperatures significantly reduced BDNF, bNGF, VEGF-A, IL-6, and sVCAM-1, while storage at – 20 °C decreased BDNF, bNGF, and VEGF- A levels. Trehalose supplementation of MSC-sec improved the outcome during storage at 4 °C and RT. Proper storage conditions were crucial for the preservation of lyophilized MSC-sec composition. Short-term storage at various temperatures maintained over 60% of the studied growth factors and cytokines; long-term preservation was only adequate at −80 °C.
Inferior vena cava filter use at a large community hospital: a retrospective cohort study
Authors: Fontyn Stephanie , Bai Yuxin , Bolger Samantha , Greco Kaity , Wang Tzu-Fei , Hamm Caroline , Cervi Andrea
Published: May 2024

Inferior vena cava (IVC) filters are considered when patients with venous thromboembolism (VTE) develop a contraindication to anticoagulation. Use of IVC filters is increasing, despite associated complications and lack of data on efficacy in reducing VTE-related mortality. We characterized the pattern of IVC filter use at a large community hospital between 2018 and 2022. Specifically, we assessed the indications for IVC filter insertion, filter removal rates, and filter-associated complications. Indications for IVC filters were compared to those outlined by current clinical practice guidelines. We reviewed 120 consecutive filter placement events. The most common indications included recent VTE and active bleeding (40.0%) or need for anticoagulation interruption for surgery (25.8%). Approximately one-third (30.0%) of IVC filters were inserted for indications either not supported or addressed by guidelines. Half (50.0%) of patients had successful removal of their IVC filter. At least 13 patients (10.8%) experienced a filter-related complication. In a large community-based practice, nearly one-third of IVC filters were inserted for indications not universally supported by current practice guidelines. Moreover, most IVC filters were not removed, raising the risk of filter-associated complications, and supporting the need for development of comprehensive guidelines addressing use of IVC filters, and post-insertion monitoring practices.
Dynamic molecular signatures of acute myocardial infarction based on transcriptomics and metabolomics
Authors: Wang Xuejiao , Yang Guang , Li Jun , Meng Chao , Xue Zengming
Published: May 2024

Acute myocardial infarction (AMI) commonly precedes ventricular remodeling, heart failure. Few dynamic molecular signatures have gained widespread acceptance in mainstream clinical testing despite the discovery of many potential candidates. These unmet needs with respect to biomarker and drug discovery of AMI necessitate a prioritization. We enrolled patients with AMI aged between 30 and 70. RNA-seq analysis was performed on the peripheral blood mononuclear cells collected from the patients at three time points: 1 day, 7 days, and 3 months after AMI. PLC/LC–MS analysis was conducted on the peripheral blood plasma collected from these patients at the same three time points. Differential genes and metabolites between groups were screened by bio-informatics methods to understand the dynamic changes of AMI in different periods. We obtained 15 transcriptional and 95 metabolite expression profiles at three time points after AMI through high-throughput sequencing. AMI-1d: enrichment analysis revealed the biological features of 1 day after AMI primarily included acute inflammatory response, elevated glycerophospholipid metabolism, and decreased protein synthesis capacity. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) might stand promising biomarkers to differentiate post-AMI stage. Anti-inflammatory therapy during the acute phase is an important direction for preventing related pathology. AMI-7d: the biological features of this stage primarily involved the initiation of cardiac fibrosis response and activation of platelet adhesion pathways. Accompanied by upregulated TGF-beta signaling pathway and ECM receptor interaction, GP5 help assess platelet activation, a potential therapeutic target to improve haemostasis. AMI-3m: the biological features of 3 months after AMI primarily showed a vascular regeneration response with VEGF signaling pathway, NOS3 and SHC2 widely activated, which holds promise for providing new therapeutic approaches for AMI. Our analysis highlights transcriptional and metabolomics signatures at different time points after MI, which deepens our understanding of the dynamic biological responses and associated molecular mechanisms that occur during cardiac repair.
Enhancement of thermal energy transfer behind a double consecutive expansion utilizing a variable magnetic field
Authors: Bahrami Hamid-Reza , Ghaedi Mahziyar
Published: May 2024

This research focuses on utilizing non-uniform magnetic fields, induced by dipoles, to control and enhance thermal energy transfer in a two-dimensional cooling conduit including a double backward-facing step. The presence of electronic equipment along the straight channel path creates such arrangements, and cooling is often ineffective in the corners of the formed steps. The use of a non-constant magnetic field is a passive technique to improve the cooling rate in these sections without changing the internal geometry, thereby increasing the heat transfer rate. A commercial software based on the finite volume technique is employed to solve the governing equations of fluid flow and heat transfer. Multiple parameters are examined in this study, including the flow Reynolds number (12.5–50), dipole location and strength (0.1–5 A-m), and the number of dipoles (single or double). The results indicate that all of these parameters have a significant impact on the thermal energy transfer. The results of the study show that a single dipole increase the average heat transfer by about 22%, two magnetic fields by 40%, the strength of the magnetic source by 24% with respect to the non-magnetic field in the present study.
Follicle-stimulating hormone receptor expression in advanced atherosclerotic plaques
Authors: Ghinea Nicolae , Liehn Elisa Anamaria , Grommes Jochen , Delattre Diane Dalila , Olesen Tine Kold
Published: May 2024

Experimental evidence indicates that follicle-stimulating hormone (FSH), an essential hormone for reproduction, can act directly on endothelial cells inducing atherosclerosis activation and development. However, it remains unknown whether the FSH-receptor (FSHR) is expressed in human atherosclerosis plaques. To demonstrate the FSHR presence, we used immunohistochemical and immunoelectron microscopy involving a specific monoclonal antibody FSHR1A02 that recognizes an epitope present in the FSHR-ectodomain. In all 55 patients with atherosclerotic plaques located in carotid, coronary, femoral arteries, and iliac aneurysm, FSHR was selectively expressed in arterial endothelium covering atherosclerotic plaques and endothelia lining intraplaque neovessels. Lymphatic neovessels were negative for FSHR. M1-macrophages, foam cells, and giant multinucleated cells were also FSHR-positive. FSHR was not detected in normal internal thoracic artery. Immunoelectron microscopy performed in ApoEKO/hFSHRKI mice with atherosclerotic plaques, after injection in vivo with mouse anti-hFSHR monoclonal antibody FSHR1A02 coupled to colloidal gold, showed FSHR presence on the luminal surface of arterial endothelial cells covering atherosclerotic plaques. Therefore, FSHR can bind, internalize, and deliver into the plaque circulating ligands to FSHR-positive cells. In conclusion, we report FSHR expression in endothelial cells, M1-macrophages, M1-derived foam cells, giant multinucleated macrophages, and osteoclasts associated with human atherosclerotic plaques.
Experimental study on failure mode and fracture evolution characteristics of red shale in Kaiyang Phosphorus mining area
Authors: Ma Zhenqian , Zhou Lang , Zuo Shaojie , Zhang Jimin
Published: May 2024

In order to study the failure mode and fracture evolution characteristics of red shale in Kaiyang Phosphorus mining area, conventional triaxial compression mechanical tests of red shale with different bedding dip angles were carried out by using DSTD-1000 electro-hydraulic servo rock mechanics experiment system. Based on the laboratory test results, the conventional triaxial particle flow simulation of red shale samples with different bedding dip angles was carried out using discrete element PFC2D. The results show that: (1) the failure mode of red shale is controlled by bedrock when the bedding dip angle is 0° and 60° ~ 90°. When the bedding dip angle is 15° ~ 45°, the rock failure mode is controlled by bedding. The compressive strength of rock is the minimum when the bedding dip angle is 30°and the maximum at 0°, which is about 2 times of the minimum. (2) In the failure process of red shale, the cracks with different bedding dip angles show slow growth stage, accelerated growth stage and stable stage with axial strain. The whole failure process is dominated by tensile cracks, accompanied by a few shear cracks. (3) The type of displacement field varies with the bedding dip angle: tensile failure and shear failure are the main displacement field types at 15° ~ 45°, and mixed failure is often the main mode at 60° ~ 90°and 0°. The research results provide the basis and reference for the safety control of red shale roadway.
Projected habitat preferences of commercial fish under different scenarios of climate change
Authors: Sharifian Sana , Mortazavi Mohammad Seddiq , Mohebbi Nozar Seyedeh Laili
Published: May 2024

The challenges of commercial species with the threats of climate change make it necessary to predict the changes in the distributional shifts and habitat preferences of the species under possible future scenarios. We aim to demonstrate how future climatic changes will affect the habitat suitability of three species of commercial fish using the predictive technique MaxEnt. The dataset used to extract geographical records included OBIS (54%), GBIF (1%), and literature (45%). The output of the model indicated accurate projections of MaxEnt (AUC above 0.9). Temperature was the main descriptor responsible for the main effects on the distribution of commercial fish. With increasing RCP from 2.5 to 8.5, the species would prefer saltier, higher temperatures and deeper waters in the future. We observed different percentages of suitable habitats between species during RCPs showing distinct sensitivity of each fish in facing climate changes. Negative effects from climate change on the distribution patterns of commercial fish were predicted to lead to varying degrees of reduction and changes of suitable habitats and movement of species towards higher latitudes. The finding emphasizes to implement adaptive management measures to preserve the stocks of these commercial fish considering that the intensification of the effects of climate change on subtropical areas and overexploited species is predicted.
Effect of the chromaticity of stimuli on night vision disturbances
Authors: Castro-Torres José J. , Casares-López Miriam , Ortiz-Peregrina Sonia , Martino Francesco , Gómez-Robledo Luis , Jiménez José R.
Published: May 2024

The perception of halos and other night vision disturbances is a common complaint in clinical practice. Such visual disturbances must be assessed in order to fully characterize each patient’s visual performance, which is particularly relevant when carrying out a range of daily tasks. Visual problems are usually assessed using achromatic stimuli, yet the stimuli encountered in daily life have very different chromaticities. Hence, it is important to assess the effect of the chromaticity of visual stimuli on night vision disturbances. The aim of this work is to study the influence of the chromaticity of different visual stimuli on night vision disturbances by analyzing straylight and visual discrimination under low-light conditions. For that, we assessed the monocular and binocular visual discrimination of 27 subjects under low illumination using the Halo test. The subjects’ visual discrimination was assessed after exposure to different visual stimuli: achromatic, red, green, and blue, both at the monitor’s maximum luminance and maintaining the same luminance value for the different visual stimuli. Monocular straylight was also measured for an achromatic, red, green, and blue stimuli. The blue stimulus had the greatest effect on halos in both monocular and binocular conditions. Visual discrimination was similar for the red, green, and achromatic stimuli, but worsened at lower luminance. The greatest influence of straylight was observed for the blue stimulus. In addition, visual discrimination correlated with straylight measurements for achromatic stimuli, wherein greater straylight values correlated with an increased perception of halos and other visual disturbances.
Field-effect Transistor Biosensors for Rapid SARS-CoV-2 Detection
Authors: Ibijbijen A. , Besbes F. , Korri-Youssoufi H.
Published: May 2024

Coronavirus disease 2019 is an emerging human infectious disease causing acute respiratory syndrome and death, which has been classified by the World Health Organization (WHO) as a pandemic. The rate of spread, virus mutation, and the lack of efficient drugs point out the need to develop point-of-care sensing devices with high accuracy and sensitivity. Among the various biosensor detection systems, field effect transistor biosensors (BioFETs) have several advantages, including high sensitivity, rapidity of measurement, and the need for a small amount of sample. Such sensing devices also have the advantage of being simple to manufacture on a large scale while utilizing nanotechnology and electronic developments. Another advantage is that they are simple to implement in POC devices with wireless reading technology and the Internet of Things for signal transmission and data analysis. This chapter is devoted to the description and discussion of BioFET systems specialized in SARS-CoV-2 detection. It highlights the state-of-the-art of BioFETs developed for SARS-CoV-2 detection regarding the FET structure, methods of functionalization through the gate or semiconductor, and FETs based on various nanomaterials such as graphene, silicon, and others. The bioanalytical detection method based on protein detection or RNA detection will be analyzed and discussed. The pros and cons of the different approaches will be reviewed, as well as their potential implementation as POC devices for early diagnosis.
Exploration of antimony(iii) oxyhalides via single-site substitution in quest of large birefringence
Authors: Hu Chenhui , Chu Dongdong , Hou Xueling , Zhang Feng , Han Jian
Published: May 2024

Using the SbOCl compound as a template, we researched six antimony(iii) oxyhalides via single-site substitution, which are favorable for generating birefringences greater than 0.1.
(±)-Hypandrone A, a pair of polycyclic polyprenylated acylphloroglucinol enantiomers with a caged 7/6/5/6/6 pentacyclic skeleton from Hypericum androsaemum
Authors: Wei Jiangchun , Fan Pingping , Huang Yahui , Zeng Hanxiao , Jiang Rui , Wu Zhengzhi , Zhang Yonghui , Hu Zhengxi
Published: May 2024

(±)-Hypandrone A (1), a pair of highly modified PPAP enantiomers, with an unprecedented caged 2,8,17-trioxapentacyclo-[11.4.2.01,9.04,9.010,15]-nonadecane core, were isolated from the fruits of Hypericum androsaemum.
The impact of pH and temperature on the green gold nanoparticles preparation using Jeju Hallabong peel extract for biomedical applications
Authors: Ariski Ridhola Tri , Lee Kyung Kwan , Kim Yongkwan , Lee Chang-Soo
Published: May 2024

Promising AuNPs were synthesized through reduction of gold chloride salt (Au3+) to gold nanoparticles (Au0) is carried out by phenolic compound as a reduction agent and flavonoid molecules as stabilizing agents by utilizing Jeju Hallabong peel extract.
Photocatalytic degradation of methyl blue dye with H2O2 sensing
Authors: Sharma Priyanka , Ganguly Mainak , Sahu Mamta
Published: May 2024

ZnO nanoparticles impregnated polymer for the degradation of methyl blue dye with H2O2 sensing colorimetrically and fluorometrically.
Construction of an electrochemical pH sensor using one-pot synthesis of a molybdenum diselenide/nitrogen doped graphene oxide screen-printed electrode
Authors: Poorahong Sujittra , Oin Wipawee , Buapoon Saowaluk , Nijpanich Supinya , Harding David J. , Siaj Mohamed
Published: May 2024

In this study, a one-pot synthesis of a molybdenum diselenide/nitrogen-doped graphene oxide (MoSe2/NGO) composite was demonstrated and used for the fabrication of an electrochemical pH sensor.
An Na/TM-site Mg substituted P2-Na2/3[Fe1/3Mg1/12Mn7/12]O2 cathode with extremely high capacity for sodium-ion batteries
Authors: Cao Ming-Hui , Li Ren-Yan , Sun Qing-Wen , Cui Miao , Guo Ze-Wei , Ma Lu , Shadike Zulipiya , Fu Zheng-Wen
Published: May 2024

The well-designed Na/TM-site Mg substituted P2-Na2/3[Fe1/3Mg1/12Mn7/12]O2 exhibits extremely high energy density, highly reversible anionic redox reaction, robust crystal structure, and superior sodium storage performance.
Stabilizing oxygen-deficient Mn sites active in seawater oxidation
Authors: Haq Tanveer ul , Smari Mourad , Tahir Aleena , Haik Yousef
Published: May 2024

This study presents the engineering of a sustainable electrode for unpurified seawater electrolysis, featuring Ca-doped manganese oxide nanorods anchored on a Ni(OH)2 microarray.
Synergistic crystallization regulation and defect passivation for growth of high-quality perovskite single crystals towards ultrasensitive X-ray detection
Authors: Chen Zhilong , Wang Hu , Fu Jie , Wang Pengxiang , Liu Xin , Dong Hao , Yang Shuang , Shao Yuchuan
Published: May 2024

This report demonstrates a method of synergistic defect passivation and crystallization regulation, which can significantly improve crystal quality and promote X-ray detector performance.
Kinetic modulation-eliminated precursor liquid inclusions in solution-grown CsPbBr3 bulk crystals for gamma-ray detection
Authors: Bai Ruichen , Ge Bangzhi , Liu Xin , Peng Xinkai , Zhang Xin , Liu Shilin , Zhu Menghua , Zhou Chongjian , Dubois Alain , Jie Wanqi , Xu Yadong
Published: May 2024

Liquid inclusion defects in CsPbBr3 crystals are attributed to natural convection generated around the crystal surface. Forced convection is introduced to eliminate liquid inclusions, and the crystal achieves high radiation detection performance.
A highly conductive, robust, self-healable, and thermally responsive liquid metal-based hydrogel for reversible electrical switches
Authors: Lee Joo Hyung , Hyun Ji Eun , Kim Jongbeom , Yang Jungin , Zhang Huanan , Ahn Hyunchul , Lee Sohee , Kim Jung Han , Lim Taehwan
Published: May 2024

A PNIPAM/LMPs hydrogel exhibits the highest electrical switching, with an unprecedented switch of 6.1 orders of magnitude. The hydrogel also possesses robust mechanical properties, a tissue-like compression modulus and self-healing capabilities.
Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal–organic frameworks
Authors: Yu Yu-Sheng , Liang Yung-Yi , Hsieh Chia-Chun , Lin Zi-Jing , Cheng Po-Hsiu , Cheng Chih-Chan , Chen Shu-Ping , Lai Lee-Jene , Wu Kevin C.-W.
Published: May 2024

Synthesis and downsizing of interpenetrated metal–organic frameworks (MOFs) for biomedical applications. Soft X-ray tomography was applied to characterize the cellular uptake of a MOF by cells.
Facile synthesis of benzothiadiazole and its derivative-based covalent organic frameworks using “two-in-one” monomers for photocatalytic hydrogen generation
Authors: Guo Jia-Xin , Wang Ze-Yang , Han Chao-Qin , Sun Shuai , Wang Lei , Lu Gonghao , Liu Xiao-Yuan
Published: May 2024

Four benzothiadiazole and its derivative-based imine-type COFs have been successfully constructed using “two-in-one” monomers for efficient photocatalytic hydrogen generation.
Bilingualism Predicts Affective Theory of Mind in Autistic Adults
Authors: Cummings Kaitlin K. , Greene Rachel K. , Cernasov Paul , Kan Dang Dang Delia , Parish-Morris Julia , Dichter Gabriel , Kinard Jessica L.
Published: May 2024

Purpose:

This study examined the impact of bilingualism on affective theory of mind (ToM) and social prioritization (SP) among autistic adults compared to neurotypical comparison participants.

Method:

Fifty-two (25 autistic, 27 neurotypical) adult participants (ages 21–35 years) with varying second language (L2) experience, ranging from monolingual to bilingual, completed an affective ToM task. A subset of this sample also completed a dynamic eye-tracking task designed to capture differences in time spent looking at social aspects of a scene (SP). Four language groups were compared on task performance (monolingual autism and neurotypical, bilingual autism and neurotypical), followed by analyses examining the contribution of L2 experience, autism characteristics, and social face prioritization on affective ToM, controlling for verbal IQ. Finally, we conducted an analysis to identify the contribution of SP on affective ToM when moderated by autism status and L2 experience, controlling for verbal IQ.

Results:

The monolingual autism group performed significantly worse than the other three groups (bilingual autism, monolingual neurotypical, and bilingual neurotypical) on the affective ToM task; however, there were no significant differences between the bilingual autism group compared to the monolingual and bilingual neurotypical groups. For autistic individuals, affective ToM capabilities were positively associated with both verbal IQ and L2 experience but did not relate to autism characteristics or SP during eye tracking. Neurotypical participants showed greater SP during the eye-tracking task, and SP did not relate to L2 or autism characteristics for autistic individuals. SP and verbal IQ predicted affective ToM performance across autism and neurotypical groups, but this relationship was moderated by L2 experience; SP more strongly predicted affective ToM performance among participants with lower L2 experience (e.g., monolingual) and had less of an impact for those with higher L2 experience.

Conclusion:

This study provides support for a bilingual advantage in affective ToM for autistic individuals.

Supplemental Material:

https://doi.org/10.23641/asha.25696083
Hydroacoustic method and GIS-Dashboard visualization for fish size in Banggai Sea Waters
Authors: Windra Alivio , Manik Henry M. , Somantri Lili , Atmadipoera Agus S. , Zuraida Rina , Priatna Asep
Published: May 2024

Estimating fish stocks, including their distribution and density, plays a vital role in the management of capture fisheries. Hydroacoustic technology is widely utilized for fish stock estimation study. In September 2022, BRIN and IPB University conducted hydroacoustic data measurement in the Banggai Sea as part of the “Banggai Upwelling Dynamics Exploration and Experiment” to estimate fish stocks. Very large fish (>58 cm) has a density of 12,452 fish km-2. The spatial distribution of fish occurs in the eastern waters of Banggai Island and the northern waters of Taliabu Island. The most significant potential is the epipelagic layer (0 to -200 meters), with very small-sized fish having the highest density, followed by large-sized and small-sized fish. To summarize the analysis results of fish density distribution , a GIS-Dashboard is utilized. This online platform integrates various maps and charts, offering an engaging and easily understandable visualization of the information.
The study of phytoplankton in the Banggai Deep Sea: The study case of Banggai Upwelling Dynamics and Ecosystem Experiment (BUDEE)
Authors: Widianingsih Widianinigsih , Hartati Retno , Atmadipura Agus Saleh , Zuraida Rina
Published: May 2024

The upwelling process in the Banggai deep-sea water occurs yearly during the east monsoon. The upwelling process is characterized by low surface water temperatures compared to the surrounding waters, high nutrient values of phosphate, nitrate, and silicate, and high values of primary productivity. The aim of this research was to determine the types of phytoplankton that are abundant in the Banggai deep-sea waters during the upwelling process. Phytoplankton sampling was conducted at 36 stations using a phytoplankton net from a depth of 150 m to the water surface. The mesh size of the phytoplankton net was 80 µm with a net length of 100 cm. Phytoplankton samples were preserved using 4% formalin. Based on the research results, the highest total abundance of phytoplankton was found at station 13 (315.457 cells.m-3), followed by stations 20 (234.746 cells.m-3), 26 (213.865 cells.m-3), station 14 (202.371 cells.m-3), station 18 (196.983 cells.m-3) and station 46 (187397 cells.m-3). Meanwhile, the other stations had an abundance of <150,000 cells/m3. The highest abundance at station 13 was dominated by the genera Bellerochea (64.068 cells.m-3), Chaetoceros (42.407 cells.m-3) and Nitzschia (35.390 cells.m-3). The high abundance of phytoplankton at Station 13 was due to upwelling.
Moving from an integrated coastal management approach to a transdisciplinary coastal management approach: A review of case study in Indonesia
Authors: Zamani Neviaty Putri , Rahimah Insaniah , Lestarina Putri Mudhlika , Harahap Zulham Apandhy , Paembonan Rustam Effendi
Published: May 2024

Coastal areas, small islands, and oceans play a vital role in the Earth’s support systems, harboring rich biodiversity. However, human activities, both direct and indirect, pose significant threats to these ecosystems. In rural regions, traditional coastal area management practices like sasi, awig-awig, sea commanders, and establishing prohibited areas are often utilized. As communities evolve and activities intensify, management strategies have shifted from community-based approaches to sectoral management, which has proven ineffective in ensuring resource sustainability.The concept of Integrated Coastal Management (ICM) emerged in the early ’90s as a collaborative approach involving various sectors, disciplines, and communities. Unfortunately, initial attempts at ICM encountered challenges and failed to adequately sustain resources and ecosystems. In response, a transdisciplinary approach to natural resource management has gained traction, focusing on holistic and sustainable solutions.This paper aims to review Indonesia’s experiences in coastal and small island management, drawing insights from existing literature. It highlights the need for transdisciplinary research to address complex coastal challenges effectively. By integrating diverse perspectives and knowledge domains, transdisciplinary approaches can enhance the sustainable management of coastal areas and support ecosystem resilience.
Oceanographic characteristics of Lampung Bay and its relationship to the Indian Ocean Dipole (IOD) period 2013-2021
Authors: Okgareta Dema , Nurjaya I Wayan , Naulita Yuli , Rastina
Published: May 2024

The Indian Ocean Dipole (IOD) may affect the distribution pattern of the sea surface temperature (SST) in the Indonesian seas. Understanding this impact is crucial for comprehending the dynamics of marine ecosystems, particularly in Lampung Bay. This study evaluates IOD effects on SST and associated upwelling/downwelling in Lampung Bay. 2014 fish catch data analysis reveals during negative IOD phases, SST increases (0.2°C to 2°C) with subsequent downwelling, coinciding with reduced catches (609.18 tons vs. 3,079 tons normal). Conversely, positive IOD phases show SST anomalies (-1°C to -2.5°C) with upwelling, correlating with increased catches to 3,349 tons in 2018. IOD-SST relationship primarily observed in Lampung Bay’s open connection to Sunda Strait (r=0.64 to 0.69), while weak correlations in coastal waters (r < 0.2) suggesting the influence of other factors on SST in Lampung Bay.
Mixing of North Pacific water masses in the Bali Sea
Authors: Pandapotan Andreas , Naulita Yuli , Hernawan Undang
Published: May 2024

As part of the Indonesian Throughflow (ITF) from western route, water masses in the Bali Sea are fed by North Pacific water masses. We examined the mixing strength in the Bali Sea which contributes to reducing the core layer S-max of the North Pacific Subtropical Water (NPSW) from 34. 8 – 35 psu in the source region to 34.5 psu in the Bali Sea. Using Thorpe method, we found the mixing strength in the Bali Sea is relatively low. The turbulent kinetic energy dissipation rate (ɛ) of O( 10-11 - 10-6 ) WKg-1 and density turbulent diffusivity (Kρ) are O (10-5 10-3) m-2s-1 were similar to typical open ocean values. However, mixing in the eastern region of the Bali Sea is relatively stronger than in the western region. Based on the critical Ri #, we found the Thorpe scale (LT) under Ri# < 0.25 in the eastern region, which is contrary to other parts. It indicated the turbulent mixing was dominantly caused by shear instability. Shear from the strong outflow of ITF towards the Lombok Strait and the reversal northward current in the lower layer forces a strong turbulent layer.
Modelling of ocean currents and distribution of total suspended solids in Citarum River estuary
Authors: Namara Aliep Fishabil , Nurjaya I Wayan , Hartanto Mochamad Tri
Published: May 2024

The Citarum River is an important river in West Java, which empties into the Java Sea carrying large suspended sediment concentrations. The purpose of this study is to examine the interaction of current patterns and distribution of total suspended solids (TSS) in the Northwest and Southeast Monsoons using hydrodynamic Modelling. The flow model and TSS used were 2-dimensional models with the OpenFlows FLOOD software. The ocean tide model results were validated using the Root Mean Square Error (RMSE) method with a value of 0.10. The current velocity in the West and East monsoons ranges from 0.07 - 0.35 m/s. Currents flow north and northeast during high-tide conditions and move south and southwest during low-tide conditions in both seasons. The movement of TSS was influenced by the current patterns. The highest concentration of TSS is in the Northwest Monsoon at low tide, which was in the range of 560–575 mg/L. The lowest TSS concentration was in the Southeast Monsoon during high tide conditions, ranging from 80 to 120 mg/L. The high concentration of TSS in the Northwest Monsoon was influenced by higher rainfall, with an average in January and only 23.2 mm/day while in the Southeast Monsoon it is only 7.8 mm/day.
Simulated ocean circulation and its variability in the Northern Banda Sea from CROCO model
Authors: Dompeipen Amanda , Apriansyah  , Atmadipoera Agus , Nabil  , Rumohoira Delta , Nugroho Dwiyoga , Natih Nyoman , Noya Yunita
Published: May 2024

A simulation of 1/24º resolution 3-dimension regional ocean circulation of CROCO was successfully performed from 2015 to 2022 (8 years), covering the ENSO year in El Niño 2015 and La Niña 2022 in the northern Banda Sea (NBS). The model and data comparison of sea surface temperature/height reproduced the observed satellite datasets well, with correlation coefficients above 0.9. It is shown that the mean circulation in the NBS is fed by two inflows from western Buru and the Manipa Strait, resulting in a meandering eastward mean circulation with warmer water accumulated in the eastern NBS, associated with high current variance south of Buru and along the Manipa Strait. Seasonal variations in the oceanographic parameters were dominant in the study area. For example, during the southeast (northwest) monsoon period, the seawater temperature is minimum (maximum) and the salinity is maximum (minimum). Furthermore, the interannual timescale ENSO and IOD significantly modulated seawater temperature and salinity variation, particularly at the thermocline layer (110 m). Much cooler and saltier water is associated with El Niño 2015 and a positive IOD, in contrast to warmer and fresher water during La Niña 2022 and a negative IOD.