bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial Activities of Ag/Cellulose Nanocomposites Derived from Marine Environment Algae against Bacterial Tooth Decay
Authors: Hamouda Ragaa A. , Makharita Rabab R. , Qarabai Fauzia A. K. , Shahabuddin Fathi S. , Saddiq Amna A. , Bahammam Laila Ahmed , El-Far Shaymaa W. , Bukhari Mamdouh A. , Elaidarous Mohammad A. , Abdella Asmaa
Published: December 2023

Dental caries is an infectious oral disease caused by the presence of different bacteria in biofilms. Multidrug resistance (MDR) is a major challenge of dental caries treatment. Swabs were taken from 65 patients with dental caries in Makkah, Saudi Arabia. Swabs were cultivated on mitis salivarius agar and de Man, Rogosa, and Sharpe (MRS) agar. VITEK 2 was used for the identification of isolated bacteria. Antibiotic susceptibility testing of the isolated bacteria was performed using commercial antibiotic disks. Ulva lactuca was used as a reducing agent and cellulose source to create nanocellulose and Ag/cellulose nanocomposites. Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction spectroscopy (XRD) were used to characterize nanocellulose and Ag/cellulose nanocomposites. The results showed that most bacterial isolates were Streptococcus spp., followed by Staphylococcus spp. on mitis salivarius media. Lactobacillus spp. and Corynebacterium group f-1 were the bacterial isolates on de Man, Rogosa, and Sharpe (MRS) media. The antibiotic susceptibility test revealed resistance rates of 77%, 93%, 0, 83%, 79%, and 79% against penicillin G, Augmentin, metronidazole, ampicillin, ciprofloxacin, and cotrimoxazole, respectively. Ag/cellulose nanocomposites and Ag/cellulose nanocomposites with fluoride were the most effective antibacterial agents. The aim of this work was to assess the antibacterial activity of Ag/cellulose nanocomposites with and without fluoride against bacteria isolated from the oral cavities of patients with dental caries. This study demonstrated that Ag/cellulose nanocomposites have antibacterial properties against multidrug-resistant bacteria that cause dental caries.
Distribution and Implications of Haloarchaeal Plasmids Disseminated in Self-Encoded Plasmid Vesicles
Authors: Lücking Dominik , Alarcón-Schumacher Tomás , Erdmann Susanne
Published: December 2023

Even though viruses and plasmids are both drivers of horizontal gene transfer, they differ fundamentally in their mode of transfer. Virus genomes are enclosed in virus capsids and are not dependent on cell-to-cell contacts for their dissemination. In contrast, the transfer of plasmids most often requires physical contact between cells. However, plasmid pR1SE of Halorubrum lacusprofundi is disseminated between cells, independent of cell-cell contacts, in specialized membrane vesicles that contain plasmid proteins. In this study, we searched for pR1SE-like elements in public databases and a metagenomics dataset from Australian salt lakes and identified 40 additional pR1SE-like elements in hypersaline environments worldwide. Herein, these elements are named apHPVs (archaeal plasmids of haloarchaea potentially transferred in plasmid vesicles). They share two sets of closely related proteins with conserved synteny, strongly indicating an organization into different functional clusters. We find that apHPVs, besides transferring themselves, have the potential to transfer large fragments of DNA between host cells, including virus defense systems. Most interestingly, apHPVs likely play an important role in the evolution of viruses and plasmids in haloarchaea, as they appear to recombine with both of them. This further supports the idea that plasmids and viruses are not distinct but closely related mobile genetic elements.
Proton Irradiation on Halide Perovskites: Numerical Calculations
Authors: Rasmetyeva Alexandra V. , Zyryanov Stepan S. , Novoselov Ivan E. , Kukharenko Andrey I. , Makarov Efrem V. , Cholakh Seif O. , Kurmaev Ernst Z. , Zhidkov Ivan S.
Published: December 2023

The results of numerical SRIM and SCAPS calculations for the ionization, displacement and heating of hybrid perovskites under the influence of protons (E = 0.15, 3.0 and 18 MeV) are presented and show that the lowest transfer energy is demonstrated by the MAPbI3, FAPbBr3 and FAPbI3 compounds, which represent the greatest potential for use as solar cells in space devices. On the other hand, it is found that perovskite compositions containing FA and Cs and with mixed cations are the most stable from the point of view of the formation of vacancies and phonons and are also promising as radiation-resistant materials with respect to powerful proton fluxes. Taking into account the lateral distribution of proton tracks showed that, at an energy level of several MeV, the release of their energy can be considered uniform over the depth and area of the entire solar cell, suggesting that the simple protection by plastic films from the low-energy protons is sufficient.
Nanostructural Characterization of Luminescent Polyvinyl Alcohol/Graphene Quantum Dots Nanocomposite Films
Authors: Elumalai Dhanumalayan , Rodríguez Beatriz , Kovtun Ganna , Hidalgo Pedro , Méndez Bianchi , Kaleemulla Shaik , Joshi Girish M. , Cuberes M. Teresa
Published: December 2023

This study focuses on the fabrication of polymer nanocomposite films using polyvinyl alcohol (PVA)/graphene quantum dots (GQDs). We investigate the relationship between the structural, thermal, and nanoscale morphological properties of these films and their photoluminescent response. Although according to X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and differential thermal analysis (DTA), the incorporation of GQDs does not significantly affect the percentage crystallinity of the PVA matrix, for a range of added GQD concentrations, atomic force microscopy (AFM) showed the formation of islands with apparent crystalline morphology on the surface of the PVA/GQD films. This observation suggests that GQDs presumably act as nucleating agents for island growth. The incorporation of GQDs also led to the formation of characteristic surface pores with increased stiffness and frictional contrast, as indicated by ultrasonic force microscopy (UFM) and frictional force microscopy (FFM) data. The photoluminescence (PL) spectra of the films were found to depend both on the amount of GQDs incorporated and on the film morphology. For GQD loads >1.2%wt, a GQD-related band was observed at ~1650 cm−1 in FT-IR, along with an increase in the PL band at lower energy. For a load of ~2%wt GQDs, the surface morphology was characterized by extended cluster aggregates with lower stiffness and friction than the surrounding matrix, and the PL signal decreased.
Effects of Malnutrition on the Immune System and Infection and the Role of Nutritional Strategies Regarding Improvements in Children’s Health Status: A Literature Review
Authors: Morales Fátima , Montserrat-de la Paz Sergio , Leon Maria J. , Rivero-Pino Fernando
Published: December 2023

Malnutrition refers to a person’s status as under- or overnourished, and it is usually associated with an inflammation status, which can subsequently imply a different health status, as the risk of infection is increased, along with a deterioration of the immune system. Children’s immune systems are generally more susceptible to problems than adults. In the situation of malnutrition, because malnourished children’s immune systems are compromised, they are more likely to die. However, little is known about the underlying mechanism of altered immune functioning and how it relates to starvation. Nutritional interventions have been reported as cost-effective strategies to prevent or treat the development of malnourishment, considering the link between food intake and health, especially in children, and also the susceptibility of this population to diseases and how their health status during childhood might affect their long-term physiological growth. The ingestion of specific nutrients (e.g., vitamins or oligoelements) has been reported to contribute to the proper functioning of children’s immune systems. In this review, we aim to describe the basis of malnutrition and how this is linked to the immune system, considering the role of nutrients in the modulation of the immune system and the risk of infection that can occur in these situations in children, as well as to identify nutritional interventions to improve their health.
Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
Authors: Konstantinou Evangelia K. , Panagiotopoulos Athanasios A. , Argyri Konstantina , Panoutsopoulos George I. , Dimitriou Maria , Gioxari Aristea
Published: December 2023

Breast cancer is the most frequent type of cancer in women. Oncogenic transcription factors promote the overproduction of cellular adhesion molecules and inflammatory cytokines during cancer development. Cancer cells exhibit significant upregulation of antiapoptotic proteins, resulting in increased cell survival, tumor growth, and metastasis. Research on the cell cycle-mediated apoptosis pathway for drug discovery and therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched for anticancer activity, providing indirect protection by activating endogenous defense systems. The role of polyphenols in key cancer signaling pathways could shed light on the underlying mechanisms of action. For instance, Rosmarinic Acid, a polyphenol constituent of many culinary herbs, has shown potent chemoprotective properties. In this review, we present recent progress in the investigation of natural products as potent anticancer agents, with a focus on the effect of Rosmarinic Acid on triple-negative BC cell lines resistant to hormone therapy. We highlight a variety of integrated chemical biology approaches aimed at utilizing relevant mechanisms of action that could lead to significant clinical advances in BC treatment.
Re-Thinking Hyperkalaemia Management in Chronic Kidney Disease—Beyond Food Tables and Nutrition Myths: An Evidence-Based Practice Review
Authors: MacLaughlin Helen L. , McAuley Erynn , Fry Jessica , Pacheco Elissa , Moran Natalie , Morgan Kate , McGuire Lisa , Conley Marguerite , Johnson David W. , Ratanjee Sharad K. , Mason Belinda
Published: December 2023

Potassium dysregulation can be life-threatening. Dietary potassium modification is a management strategy for hyperkalaemia. However, a 2017 review for clinical guidelines found no trials evaluating dietary restriction for managing hyperkalaemia in chronic kidney disease (CKD). Evidence regarding dietary hyperkalaemia management was reviewed and practice recommendations disseminated. A literature search using terms for potassium, hyperkalaemia, and CKD was undertaken from 2018 to October 2022. Researchers extracted data, discussed findings, and formulated practice recommendations. A consumer resource, a clinician education webinar, and workplace education sessions were developed. Eighteen studies were included. Observational studies found no association between dietary and serum potassium in CKD populations. In two studies, 40–60 mmol increases in dietary/supplemental potassium increased serum potassium by 0.2–0.4 mmol/L. No studies examined lowering dietary potassium as a therapeutic treatment for hyperkalaemia. Healthy dietary patterns were associated with improved outcomes and may predict lower serum potassium, as dietary co-factors may support potassium shifts intracellularly, and increase excretion through the bowel. The resource recommended limiting potassium additives, large servings of meat and milk, and including high-fibre foods: wholegrains, fruits, and vegetables. In seven months, the resource received > 3300 views and the webinar > 290 views. This review highlights the need for prompt review of consumer resources, hospital diets, and health professionals’ knowledge.
RNA-Seq of Phenotypically Distinct Eimeria maxima Strains Reveals Coordinated and Contrasting Maturation and Shared Sporogonic Biomarkers with Eimeria acervulina
Authors: Tucker Matthew S. , O’Brien Celia N. , Johnson Alexis N. , Dubey Jitender P. , Rosenthal Benjamin M. , Jenkins Mark C.
Published: December 2023

Strains of Eimeria maxima, an enteric parasite of poultry, vary in virulence. Here, we performed microscopy and RNA sequencing on oocysts of strains APU-1 (which exhibits more virulence) and APU-2. Although each underwent parallel development, APU-1 initially approached maturation more slowly. Each strain sporulated by hour 36; their gene expression diverged somewhat thereafter. Candidate biomarkers of viability included 58 genes contributing at least 1000 Transcripts Per Million throughout sporulation, such as cation-transporting ATPases and zinc finger domain-containing proteins. Many genes resemble constitutively expressed genes also important to Eimeria acervulina. Throughout sporulation, the expression of only a few genes differed between strains; these included cyclophilin A, EF-1α, and surface antigens (SAGs). Mature and immature oocysts uniquely differentially express certain genes, such as an X-Pro dipeptidyl-peptidase domain-containing protein in immature oocysts and a profilin in mature oocysts. The immature oocysts of each strain expressed more phosphoserine aminotransferase and the mature oocysts expressed more SAGs and microneme proteins. These data illuminate processes influencing sporulation in Eimeria and related genera, such as Cyclospora, and identify biological processes which may differentiate them. Drivers of development and senescence may provide tools to assess the viability of oocysts, which would greatly benefit the poultry industry and food safety applications.
Synthesis, Characterization, and Investigation of Anti-Inflammatory and Cytotoxic Activities of Novel Thiourea Derivatives of Naproxen
Authors: Nedeljković Nikola , Nikolić Miloš , Čanović Petar , Zarić Milan , Živković Zarić Radica , Bošković Jelena , Vesović Marina , Bradić Jovana , Anđić Marijana , Kočović Aleksandar , Nikolić Marina , Jakovljević Vladimir , Vujić Zorica , Dobričić Vladimir
Published: December 2023

The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate the cytotoxic potential of both sets of synthesized compounds (1–7 and 8–14), and select the most promising anti-inflammatory and antitumor drug candidates. The results of the in vivo anti-inflammatory study clearly showed that compounds 8 and 9 were capable of decreasing paw edema, as evident from a high percentage of inhibition (44.83% and 49.29%, respectively). In addition, the results of in vitro enzyme inhibition assays demonstrated that neither of the newly synthesized compounds reached 50% inhibition of 5-LOX at concentrations lower than 100 µM. In terms of antitumor potential, derivatives 3 and 8 exhibited strong cytotoxic effects on the HeLa cell line, suggesting the involvement of the extrinsic pathway of apoptosis. According to the overall results obtained for both sets of synthesized molecules, derivatives 4 and 8 can be underlined as molecules with the strongest anti-inflammatory activity, while derivatives 3 and 8 are the most promising cytotoxic agents.
Update and Application of a Deep Learning Model for the Prediction of Interactions between Drugs Used by Patients with Multiple Sclerosis
Authors: Hecker Michael , Frahm Niklas , Zettl Uwe Klaus
Published: December 2023

Patients with multiple sclerosis (MS) often take multiple drugs at the same time to modify the course of disease, alleviate neurological symptoms and manage co-existing conditions. A major consequence for a patient taking different medications is a higher risk of treatment failure and side effects. This is because a drug may alter the pharmacokinetic and/or pharmacodynamic properties of another drug, which is referred to as drug-drug interaction (DDI). We aimed to predict interactions of drugs that are used by patients with MS based on a deep neural network (DNN) using structural information as input. We further aimed to identify potential drug-food interactions (DFIs), which can affect drug efficacy and patient safety as well. We used DeepDDI, a multi-label classification model of specific DDI types, to predict changes in pharmacological effects and/or the risk of adverse drug events when two or more drugs are taken together. The original model with ~34 million trainable parameters was updated using >1 million DDIs recorded in the DrugBank database. Structure data of food components were obtained from the FooDB database. The medication plans of patients with MS (n = 627) were then searched for pairwise interactions between drug and food compounds. The updated DeepDDI model achieved accuracies of 92.2% and 92.1% on the validation and testing sets, respectively. The patients with MS used 312 different small molecule drugs as prescription or over-the-counter medications. In the medication plans, we identified 3748 DDIs in DrugBank and 13,365 DDIs using DeepDDI. At least one DDI was found for most patients (n = 509 or 81.2% based on the DNN model). The predictions revealed that many patients would be at increased risk of bleeding and bradycardic complications due to a potential DDI if they were to start a disease-modifying therapy with cladribine (n = 242 or 38.6%) and fingolimod (n = 279 or 44.5%), respectively. We also obtained numerous potential interactions for Bruton’s tyrosine kinase inhibitors that are in clinical development for MS, such as evobrutinib (n = 434 DDIs). Food sources most often related to DFIs were corn (n = 5456 DFIs) and cow’s milk (n = 4243 DFIs). We demonstrate that deep learning techniques can exploit chemical structure similarity to accurately predict DDIs and DFIs in patients with MS. Our study specifies drug pairs that potentially interact, suggests mechanisms causing adverse drug effects, informs about whether interacting drugs can be replaced with alternative drugs to avoid critical DDIs and provides dietary recommendations for MS patients who are taking certain drugs.
Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase
Authors: Khramtsov Yuri V. , Ulasov Alexey V. , Lupanova Tatiana N. , Slastnikova Tatiana A. , Rosenkranz Andrey A. , Bunin Egor S. , Georgiev Georgii P. , Sobolev Alexander S.
Published: December 2023

The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a biologically active agent that provides the degradation of one of these key proteins and/or destroys the viral factory could suppress viral replication efficiently. The nucleocapsid protein (N-protein) is a key protein for the SARS-CoV-2 virus. As a bioactive agent, we offer a modular nanotransporter (MNT) developed by us, which, in addition to an antibody mimetic to the N-protein, contains an amino acid sequence for the attraction of the Keap1 E3 ubiquitin ligase. This should lead to the subsequent degradation of the N-protein. We have shown that the functional properties of modules within the MNT permit its internalization into target cells, endosome escape into the cytosol, and binding to the N-protein. Using flow cytometry and western blotting, we demonstrated significant degradation of N-protein when A549 and A431 cells transfected with a plasmid coding for N-protein were incubated with the developed MNTs. The proposed MNTs open up a new approach for the treatment of viral diseases.
A Thermodynamic Comparison of Nanotip and Nanoblade Geometries for Ultrafast Laser Field Emission via the Finite Element Method
Authors: Mann Joshua , Rosenzweig James
Published: December 2023

Strong laser field emission from metals is a growing area of study, owing to its applications in high-brightness cathodes and potentially as a high harmonic generation source. Nanopatterned plasmonic cathodes localize and enhance incident laser fields, reducing the spot size and increasing the current density. Experiments have demonstrated that the nanoblade structure outperforms nanotips in the peak fields achieved before damage is inflicted. With more intense surface fields come brighter emissions, and thus investigating the thermomechanical properties of these structures is crucial in their characterization. We study, using the finite element method, the electron and lattice temperatures for varying geometries, as well as the opening angles, peak surface fields, and apex radii of curvature. While we underestimate the energy deposited into the lattice here, a comparison of the geometries is still helpful for understanding why one structure performs better than the other. We find that the opening angle—not the structure dimensionality—is what primarily determines the thermal performance of these structures.
Regenerating Saffron (Crocus sativus L.) from Corm Lateral Buds via Indirect Somatic Embryogenesis
Authors: Ma Yangyang , Pan Yiyu , Mao Bizeng
Published: December 2023

Saffron (Crocus sativus L.), being one of the distinguished commercial spice crops in the world, is in demand for its culinary, colorant, and pharmaceutical benefits. In this study, a novel indirect somatic embryogenesis (SE) system was, thus, established for the study of this plant. To this end, firstly, the lateral buds were cultured. Then, the cultures were transformed using Murashige and Skoog (MS) medium supplemented with either 6-benzyladenine (BA: 5 and 10 mg/L), naphthalene acetic acid (NAA: 0, 1, and 2 mg/L), or trans-zeatin (tZ: 0, 0.5, and 1.0 mg/L), before being classified into four structures: white globular (WG), yellow compact nodular (YCN), yellow-brown fragile (YBF), and dark-brown porous (DBP). As soon as BA (10 mg/L) and NAA (2 mg/L) were added, elevated percentages of white globular calli (56.8%) and white globular calli (31.5%) structures were induced. Additionally, 6-benzyladenine (5 mg/L) and naphthalene acetic acid (1 mg/L) allowed the formation of yellow-brown fragile structures, and the combination of 6-benzyladenine (10 mg/L) with trans-zeatin (1 mg/L) formed the DBP structures. After three months, the white globular calli were incubated using the MS basal medium, before being augmented with thidiazuron (TDZ: 1 mg/L) and picloram (PIC: 2 mg/L), from which 60% of the cases matured into shoots and, ultimately, cormlets. Morphoanatomical analyses also showed that the white globular calli cells were closely arranged, as they had a dense cytoplasm, a significant vascular differentiation, and embryoids. Furthermore, the yellow compact nodular structures were characterized by a strong differentiation capacity and contained many meristematic cells with high caryomitosis centers. We observed that the yellow-brown fragile calli had looser cell arrangements, with a vascular structure located on the protoderm edge, while there was no obvious cellular arrangement in the dark-brown porous structures. The induction of the adventitious buds in vivo on the MS medium that was supplemented with thidiazuron and picloram accordingly demonstrated the highest rates (60%) of white globular calli.
Advancements in Fiber-Reinforced Polymer Composites: A Comprehensive Analysis
Authors: Diniță Alin , Ripeanu Razvan George , Ilincă Costin Nicolae , Cursaru Diana , Matei Dănuța , Naim Ramadan Ibrahim , Tănase Maria , Portoacă Alexandra Ileana
Published: December 2023

Composites made from fiber-reinforced polymers (FRPs) are a crucial and highly adaptable category of materials widely utilized in numerous fields. Their flexibility and the range of criteria for classification enable the creation of tailored solutions to address distinct requirements in sectors such as civil engineering, aerospace, automotive, and marine, among others. The distinguishing characteristics of FRP composites include the type of reinforcing fiber used, the composition of the matrix material, the employed manufacturing process, the orientation of the fibers, and the specific end-use application. These classification variables offer engineers a versatile structure to determine and select the most appropriate materials and production techniques for their specific needs. Furthermore, the present study aims to reunite the criteria of classification for FRPs and specific manufacturing technologies of FRPs, such as conventional ones (matched die molding, contact molding), automated ones (filament winding, tape lay-up, and fiber placement), and advanced ones (electrospinning and additive manufacturing),with the chronological development of FRPs, insights on material characteristics, and comprehensive design guidelines based on their behavior in different environments of use.
Construction Strategy for Flexible and Breathable SiO2/Al/NFs/PET Composite Fabrics with Dual Shielding against Microwave and Infrared–Thermal Radiations for Wearable Protective Clothing
Authors: Ye Hui , Liu Qiongzhen , Xu Xiao , Song Mengya , Lu Ying , Yang Liyan , Wang Wen , Wang Yuedan , Li Mufang , Wang Dong
Published: December 2023

Microwave and infrared–thermal radiation-compatible shielding fabrics represent an important direction in the development of wearable protective fabrics. Nevertheless, effectively and conveniently integrating compatible shielding functions into fabrics while maintaining breathability and moisture permeability remains a significant challenge. Here, we take hydrophilic PVA-co-PE nanofibrous film-coated PET fabric (NFs/PET) as a flexible substrate and deposit a dielectric/conductive (SiO2/Al) bilayer film via magnetron sputtering. This strategy endows the fabric surface with high electrical conductivity, nanoscale roughness comparable to visible and infrared waves, and a dielectric–metal contact interface possessing localized plasmon resonance and Mie scattering effects. The results demonstrate that the optimized SiO2/Al/NFs/PET composite conductive fabric (referred to as S4-1) possesses favorable X-band electromagnetic interference (EMI) shielding effectiveness (50 dB) as well as excellent long-wave infrared (LWIR) shielding or IR stealth performance (IR emissivity of 0.60). Notably, the S4-1 fabric has a cooling effect of about 12.4 °C for a heat source (80 °C) and an insulating effect of about 17.2 °C for a cold source (−20 °C), showing excellent shielding capability for heat conduction and heat radiations. Moreover, the moisture permeability of the S4-1 fabric is about 300 g/(m2·h), which is better than the requirement concerning moisture permeability for wearable fabrics (≥2500–5000 g/(m2·24 h)), indicating excellent heat and moisture comfort. In short, our fabrics have lightweight, thin, moisture-permeable and excellent shielding performance, which provides novel ideas for the development of wearable multi-band shielding fabrics applied to complex electromagnetic environments.
Thermosensitive Scattering Hydrogels Based on Triblock Poly-Ethers: A Novel Approach to Solar Radiation Regulation
Authors: Qian Dewei , Yang Siyu , Wang Xiaofang , Tian Yang , Wen Weijia
Published: December 2023

Energy conservation in buildings is paramount, especially considering that glass accounts for 50% of energy consumption. The solar heat gain coefficient (SHGC) of glass is a critical energy-saving index for transparent structures. However, the fixed SHGC of ordinary glass makes it difficult to provide both summer shading and winter heating. In this study, we synthesized a hydrogel with a thermosensitive scattering (TS) property using triblock polyether and acrylamide. This hydrogel can realize the transition of clearness and atomization based on the temperature. When sealed within a glass cavity, it exhibits a high SHGC of 0.682 in its transparent state and a low SHGC of less than 0.31 when atomized. The lower critical solution temperature (LCST) of the TS glass can be adjusted from 0 to 70 °C to suit different regions. The photothermal properties of the material remained stable after 200 hot and cold cycles and 200 h of ultraviolet irradiation. This glass can prevent solar radiation from entering the room in summer, thereby reducing air conditioning usage and power consumption. In winter, it allows solar heat radiation to enter the room, minimizing the need for artificial heating. Its adaptable temperature design makes it an excellent solution for designers to create energy-efficient building exteriors.
Enhanced Enzymatic Production of Antioxidant Peptides from Carya cathayensis Cake Using an Enzymatic Membrane-Coupled Reactor
Authors: Wang Qingqing , Chang Yinzi , Yuan Qinjie , Wu Fenghua , Hu Hao , Zhang Jiaojiao , He Zhiping
Published: December 2023

This study establishes an enzymatic membrane-coupled production process for antioxidant peptides from Carya cathayensis cake by comparing the effects of not feeding, water feeding, substrate feeding, and gradient dilution feeding supplementary material modes, to assess their impact on production efficiency. The optimal operational conditions were determined as follows: pH 10.5, temperature 50 °C, and enzyme-to-substrate ratio of 10% (w/w). The continuous production using the gradient dilution supplementary material mode resulted in Chinese pecan antioxidant peptides with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging rate of 0.044 mg/mL, 2, 2-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) radical scavenging rate of 0.518 mg/mL, and ferrous ion chelating ability (IC50) of 0.252 mg/mL. Compared with traditional enzymatic hydrolysis processes, the gradient dilution supplementary material enzymatic membrane-coupled production process increased peptide yield, peptide production, and unit enzyme-peptide production by 14.36%, 11.35%, and 235.63%, respectively. This continuous production method facilitates scalability, enabling the production of high-yield and high-activity Carya cathayensis cake peptides, making better use of byproducts after oil extraction, and laying a solid foundation for the comprehensive development and deep processing of Chinese pecan, thus enhancing its economic value.
Wastewater Treatment Using Shear Enhanced Flotation Separation Technology: A Pilot Plant Study for Winery Wastewater Processing
Authors: Vlotman David , Key David , Cerff Bradley , Bladergroen Bernard Jan
Published: December 2023

The agricultural sector is one that requires and consumes enormous amounts of fresh water globally. Commercial wine production in particular uses large volumes of fresh water and, through various processes, generates significant quantities of wastewater. The wastewater produced by wineries typically exhibits elevated levels of chemical oxygen demand (COD), total suspended solids (TSS), an acidic pH, and varying salinity and nutrient contents. The overall characteristics of winery wastewater indicate that it is a potential environmental hazard if not processed and disposed of appropriately. Due to significant variations in wastewater contaminant levels among wineries, the implementation of a universally applicable, environmentally friendly, and sustainable waste management system seems practically unattainable. This study investigated the design, fabrication, and modification of a shear enhanced flotation separation (SEFS) pilot plant to be used as a primary treatment stage during winery wastewater processing. This technology combines the synergistic advantages of hydrodynamic shear, coagulation, flocculation, and dissolved air flotation. To date, there have been only limited publications on the feasibility and application of hydrodynamic shear and its potential to assist with coagulation/flocculation and flotation efficiencies specifically for winery wastewater treatment. The results obtained indicate that the SEFS pilot plant may well be able to process winery wastewater to a quality level where reuse of the water for irrigation of crops may be considered.
Creation and Grace: Understanding the Pre-Modern Frame of Aquinas’ Approach to Sanctification
Authors: Lynch Reginald
Published: December 2023

This article proposes a Thomistic account of graced human nature that emphasizes the importance of underlying developments in Aquinas’ doctrine of creation that inform his approach to the doctrine of grace. While post-Cartesian accounts of the human person often reduce the complex causal structure that marks the relationship between God and the human person in Aquinas’ pre-modern theological anthropology, this article recovers a more comprehensive account of Aquinas’ account of human sanctification and divine causality. Where modern and postmodern anthropologies are often marked by scientific determinism or subjectivism, Aquinas’s anthropology of grace refuses the modern dichotomization of immanence and transcendence, proposing instead an understanding of grace as the divinization of the human person as image of God that is marked not only by the supernatural finality of beatitude, but the intrinsic and personal immanence of divine indwelling.
A Review of Trajectory Prediction Methods for the Vulnerable Road User
Authors: Schuetz Erik , Flohr Fabian B.
Published: December 2023

Predicting the trajectory of other road users, especially vulnerable road users (VRUs), is an important aspect of safety and planning efficiency for autonomous vehicles. With recent advances in Deep-Learning-based approaches in this field, physics- and classical Machine-Learning-based methods cannot exhibit competitive results compared to the former. Hence, this paper provides an extensive review of recent Deep-Learning-based methods in trajectory prediction for VRUs and autonomous driving in general. We review the state and context representations and architectural insights of selected methods, divided into categories according to their primary prediction scheme. Additionally, we summarize reported results on popular datasets for all methods presented in this review. The results show that conditional variational autoencoders achieve the best overall results on both pedestrian and autonomous driving datasets. Finally, we outline possible future research directions for the field of trajectory prediction in autonomous driving.
Automated High-Resolution Bathymetry from Sentinel-1 SAR Images in Deeper Nearshore Coastal Waters in Eastern Florida
Authors: Mudiyanselage Sanduni D. , Wilkinson Ben , Abd-Elrahman Amr
Published: December 2023

Synthetic aperture radar (SAR) imagers are active microwave sensors that could overcome many challenges of passive optical bathymetry inversion, yet their capacity to yield accurate high-resolution bathymetric mapping is not studied sufficiently. In this study, we evaluate the feasibility of applying fast Fourier transform (FFT) to SAR data in coastal nearshore bathymetry derivation in Florida’s coastal waters. The study aims to develop a robust SAR bathymetry inversion framework across extensive spatial scales to address the dearth of bathymetric data in deeper nearshore coastal regions. By leveraging the Sentinel-1 datasets as a rich source of training data, our method yields high-resolution and accurate depth extraction up to 80 m. A comprehensive workflow to determine both the wavelength and peak wave period is associated with the proposed automated model compilation. A novel contour geometry-based spectral analysis technique for wavelength retrieval is presented that enables an efficient and scalable SAR bathymetry model. Multi-date SAR images were used to assess the robustness of the proposed depth-retrieval model. An accuracy assessment against the GMRT data demonstrated the high efficacy of the proposed approach, achieving a coefficient of determination (R2) above 0.95, a root-mean-square error (RMSE) of 1.56–10.20 m, and relative errors of 3.56–11.08% in automatically extracting the underwater terrain at every 50 m interval. A sensitivity analysis was conducted to estimate the uncertainty associated with our method. Overall, this study highlights the potential of SAR technology to produce updated, cost-effective, and accurate bathymetry maps of high resolution and to fill bathymetric data gaps worldwide. The code and datasets are made publicly available.
Classification of Urban Surface Elements by Combining Multisource Data and Ontology
Authors: Zhu Ling , Lu Yuzhen , Fan Yewen
Published: December 2023

The rapid pace of urbanization and increasing demands for urban functionalities have led to diversification and complexity in the types of urban surface elements. The conventional approach of relying solely on remote sensing imagery for urban surface element extraction faces emerging challenges. Data-driven techniques, including deep learning and machine learning, necessitate a substantial number of annotated samples as prerequisites. In response, our study proposes a knowledge-driven approach that integrates multisource data with ontology to achieve precise urban surface element extraction. Within this framework, components from the EIONET Action Group on Land Monitoring in Europe matrix serve as ontology primitives, forming a shared vocabulary. The semantics of surface elements are deconstructed using these primitives, enabling the creation of specific descriptions for various types of urban surface elements by combining these primitives. Our approach integrates multitemporal high-resolution remote sensing data, network big data, and other heterogeneous data sources. It segments high-resolution images into individual patches, and for each unit, urban surface element classification is accomplished through semantic rule-based inference. We conducted experiments in two regions with varying levels of urban scene complexity, achieving overall accuracies of 93.03% and 97.35%, respectively. Through this knowledge-driven approach, our proposed method significantly enhances the classification performance of urban surface elements in complex scenes, even in the absence of sample data, thereby presenting a novel approach to urban surface element extraction.
Effects of Hydrolysis Condition and Detection Method on the Monosaccharide Composition Analysis of Polysaccharides from Natural Sources
Authors: Zhao Meijuan , Kuang Fengyan , Zhang Yingyue , Lv Guangping
Published: December 2023

Monosaccharide composition analysis is essential to the structural characterization and research into the biological activity of polysaccharides. In this study, a systematic comparison was performed among commonly used monosaccharide composition analysis methods, including colorimetric and chromatographic methods. These were tested on 16 aldoses, ketoses, alditols, amino sugars, and uronic acids. Furthermore, the effect of hydrolysis methods was also investigated. The results showed that the phenol sulfuric acid method is greatly affected by the type of monosaccharide that is used as the reference substance. The determination of uronic acid using sulfuric acid carbazole is less affected by neutral sugars than that method using m-hydroxybiphenyl. The high-performance thin-layer chromatography (HPTLC) method can simultaneously analyze multiple samples and accurately determine the type of uronic acid. High-performance liquid chromatography (HPLC) can provide a good qualitative and quantitative analysis of aldose, amino sugars, and uronic acids, while gas chromatography–mass spectrometry (GC-MS) can detect aldose, ketose, and alditols. Fructose was detected in a large amount in inulin and Codonopsis pilosula after one-step hydrolysis, while it was totally destroyed in two-step hydrolysis. The release of galacturonic acid significantly increased after two-step hydrolysis in pectin and Lycium barbarum, which indicated that one-step hydrolysis is not enough for acidic polysaccharides. The results of this study are beneficial for selecting appropriate hydrolysis and analysis methods in order to accurately analyze the monosaccharide compositions of natural polysaccharides.
Restoration of the Nanjing Circumvallation in Sustainable Urban Planning: Application of Environmental Ethical Decision-Making Model
Authors: Lv Wenyu , Dai Di , Wei Renjie , Bai Lanlan
Published: December 2023

The Nanjing Circumvallation has been severely damaged due to natural factors, human interference, and urban expansion. Restoring this edifice serves not only as a preservation of historikcal and cultural values, but also as an advancement towards sustainable urban development. This research proposes an environmental ethical decision-making model (EEDM) grounded in sustainable urban development indicators. The model is then applied to the restoration of the Nanjing Circumvallation. Based on feedback from the research trial section, the renovation of the Circumvallation trial segment, guided by the EEDM, effectively embodies the core principles of sustainable urban development. By extending this model to the entire restoration project, it is feasible to achieve a harmonious balance between heritage preservation and urban sustainability. This methodology offers a novel framework for the restoration of similar heritage sites, ensuring the concurrent achievement of conservation and sustainable development goals. Furthermore, this approach holds considerable promise for fostering sustainable urban progression.
Analysis of the Potential Economic Impact of Parking Space Comprehensive Utilization on Traditional Business District
Authors: Guo Jun , Guan Hongzhi , Han Yan , Xue Yunqiang
Published: December 2023

This paper investigates the latent classes of parking preference for drivers and the economic effects after implementing Parking Space Comprehensive Utilization (PSC) in traditional business districts (TBD), with a particular focus on the parking preferences of electric vehicle users (EVU). Firstly, Exploratory Factor Analysis (EFA) is used to reduce dimensionality and determine the latent structure. Then, based on the Latent Class Model (LCM), the customers are classified, and the proportion of each class under various latent variables is analyzed. Finally, the paper conducts a quantitative analysis of economic effects by considering different psychological factors across different customer classes. With the data obtained from revealed preference (RP) and stated preference (SP) surveys, this paper identifies the customers’ preferences for the three scenarios presented. The results show that (1) customers can be classified into four classes: core customers (CCS, 34%), potential customers (PCS, 29%), regular customers (RCS, 22%), and marginal customers (MCS, 15%), among which EVU do not show a significant preference for parking charging facilities in TBD; (2) the potential economic improvements for these four classes are: 9%, 12%, 8%, and 10%; (3) CCS has the greatest potential to increase store revenue by ¥7041, while PCS has the greatest potential to increase store customer flow by 31%. These findings provide a valuable reference for decision-making by TBD store managers.
Sustainable Valorization of Sour Cherry (Prunus cerasus) By-Products: Extraction of Antioxidant Compounds
Authors: Chatzimitakos Theodoros , Athanasiadis Vassilis , Kalompatsios Dimitrios , Kotsou Konstantina , Mantiniotou Martha , Bozinou Eleni , Lalas Stavros I.
Published: December 2023

Prunus cerasus, commonly known as sour cherry, is a fruit widely consumed during the summer season. Processing of sour cherries results in the generation of substantial amounts of by-products. Following the extraction of juice, the residual pomace (comprising of skin and flesh) and pits remain as by-products. This study delves into the antioxidant potential derived from the phenolic compounds present in sour cherry pomace and the oil derived from its seeds, both demonstrating significant implications for human health and longevity. The increasing demand for bioactive compounds from natural resources, to be used as ingredients in functional foods, as well as the increased global production of sour cherries, has spurred considerable interest in these by-products. The growing demand for more sustainable practices has necessitated the use of industrial fruit by-products. To this end, many articles have been published regarding sour cherry skin and pits utilization. This comprehensive review aims to elucidate advanced techniques for extracting antioxidants from sour cherries and discern optimal strategies for broad-scale industrial implementation.
A Simplified Optimization Model for Hydrokinetic Blades with Diffuser and Swept Rotor
Authors: Andrade Silvia C. de P. , do Rio Vaz Déborah A. T. D. , Vaz Jerson R. P.
Published: December 2023

The use of a diffuser in hydrokinetic turbines can improve the power coefficient. However, the risk of cavitation in the rotor blades increases. Studies suggest that backward-curved blades can reduce the axial load on the rotor and therefore prevent cavitation. Therefore, this work develops an optimization procedure applied to backward-curved blades in hydrokinetic turbines with diffusers based on the Blade Element Momentum Theory. The main contribution is to consider both the sweep effect and the presence of a diffuser in the optimization in an innovative way. We use a radial transformation function that adjusts the radial position considering the curvature of the blade during optimization under the effect of the diffuser. The results showed that the increase in blade curvature resulted in greater chord distributions and twist angles, especially at the blade tips. The Prandtl’s loss factor was not sensitive to sweep, but the linked circulation increased at the blade tips, suggesting an increased risk of cavitation. Depending on the sweep angle, the optimized blades were able to mitigate or avoid cavitation. In particular, a sweep angle of 30∘ eliminated cavitation. This study indicated that the proposed optimization can effectively prevent cavitation, showing satisfactory results.
Plane Partitions and Divisors
Authors: Ballantine Cristina , Merca Mircea
Published: December 2023

In this paper, we consider the sum of divisors d of n such that n/d is a power of 2 and derive a new decomposition for the number of plane partitions of n in terms of binomial coefficients as a sum over partitions of n. In this context, we introduce a new combinatorial interpretation of the number of plane partitions of n.
Do Surface Charges on Polymeric Filters and Airborne Particles Control the Removal of Nanoscale Aerosols by Polymeric Facial Masks?
Authors: Zhang Zhaobo , Ersan Mahmut S. , Westerhoff Paul , Herckes Pierre
Published: December 2023

The emergence of facial masks as a critical health intervention to prevent the spread of airborne disease and protect from occupational nanomaterial exposure highlights the need for fundamental insights into the interaction of nanoparticles (<200 nm) with modern polymeric mask filter materials. While most research focuses on the filtration efficiency of airborne particles by facial masks based on pore sizes, pressure drop, or humidity, only a few studies focus on the importance of aerosol surface charge versus filter surface charge and their role in the net particle filtration efficiency of mask filters. In this study, experiments were conducted to assess mask filter filtration efficiency using positively and negatively charged polystyrene particles (150 nm) as challenge aerosols at varying humidity levels. Commercial masks with surface potential (Ψf) in the range of −10 V to −800 V were measured by an electrostatic voltmeter and used for testing. Results show that the mask filtration efficiency is highly dependent on the mask surface potential as well as the charge on the challenge aerosol, ranging from 60% to 98%. Eliminating the surface charge results in a maximum 43% decrease in filtration efficiency, emphasizing the importance of electrostatic charge interactions during the particle capture process. Moreover, increased humidity can decrease the surface charge on filters, thereby decreasing the mask filtration efficiency. The knowledge gained from this study provides insight into the critical role of electrostatic attraction in nanoparticle capture mechanisms and benefits future occupational and environmental health studies.