bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil sociodemográfico e sociopolítico de profissionais de enfermagem eleitos para o cargo de prefeitos nos pleitos no Brasil em 2020
Authors: Benito Linconl Agudo Oliveira , Benito Rosana da Cruz , Silva Izabel Cristina Rodrigues da , Azevedo Helder Lima Garcia , Aguiar Valéria Cristina da Silva
Published: November 2024

Objetivo: Analisar o quantitativo de profissionais de enfermagem eleitos para o cargo de prefeitos nos pleitos municipais realizados no recorte geográfico formado pelo “Brasil” no ano de 2020, construindo também o seu perfil sociodemográfico e sociopolítico. Método: Pesquisa exploratória, descritiva, comparativa e quantitativa. Os dados foram solicitados no Tribunal Superior Eleitoral (TSE). Resultados: No processo de organização e análise dos dados, foram identificados 120 profissionais, sendo que 77,5% (n=93) eram de Enfermeiros (ENF) e 22,5% (n=27) eram de Técnicos de Enfermagem e Assemelhados (TEA). A região sudeste (SE) registrou a maior preponderância de ENF com 40,9% (n=38) e a região nordeste (NE) a maior de TEA com 29,6% (n=8). O estado de Minas Gerais (MG) registrou a maior preponderância de ENF com 21,5% (n=20) e de TEA com 14,8% (n=4). Considerações finais: A presente pesquisa verificou a reduzida representação de profissionais de enfermagem nos pleitos eleitorais municipais realizados no Brasil em 2020.
Sífilis Congênita: estudo de caso
Authors: Matos Natália Batista , Ribeiro Leila Batista , Correia Sara Fernandes , Rosa Marcos Antonio de Carvalho , Morais Jefferson Amaral de , Silva Caio César Medeiros da , Faria Tarcísio Souza , Santos Elissandro Noronha dos
Published: November 2024

Objetivo: abordar a sífilis congênita como um sério problema de saúde pública no Brasil, destacando suas complicações, fisiopatologia e desafios no diagnóstico e tratamento, além de apresentar um caso clínico ilustrativo. Metodologia: A pesquisa consistiu em abordagem qualitativa e método de revisão bibliográfica e estudo de caso clínico de uma paciente com suspeita de sífilis congênita. Foram utilizadas fontes confiáveis e atualizadas para embasar as discussões sobre a epidemiologia, fisiopatologia, diagnóstico, tratamento e cuidados de enfermagem relacionados à sífilis congênita. Resultados: A sífilis congênita representa um desafio significativo para a saúde pública no Brasil, com potencial para causar óbitos neonatais e complicações graves. A transmissão vertical da infecção é um problema complexo, muitas vezes agravado por disparidades de acesso e qualidade do cuidado pré-natal. O diagnóstico precoce é fundamental, mas enfrenta obstáculos devido à presença de anticorpos maternos e à necessidade de procedimentos diagnósticos específicos para recém-nascidos. O tratamento com penicilina é essencial para prevenir complicações no desenvolvimento fetal, com doses adequadas prescritas para cada estágio da doença. Conclusão: O estudo de caso destacou a importância da anamnese detalhada, exame físico minucioso e estratégias de cuidados de enfermagem para fornecer um tratamento eficaz e abrangente aos pacientes com sífilis congênita
Analisis Kinerja dan Harmonik Motor Induksi 3 Fasa Dengan Variable Frequency Drive pada Boiler Feed Water Pump di PT. Cahaya Fajar Kaltim Menggunakan ETAP
Authors: Suratno Suratno , Ashabullah Muhammad Hafiz , Yadie Erry
Published: November 2024

Boiler Feed Water Pump (BFWP) merupakan peralatan penting di Pembangkit Listrik Tenaga Uap (PLTU) yang berfungsi mengalirkan air umpan dari deaerator ke boiler. Penggunaan Variable Frequency Drive (VFD) pada BFWP bertujuan untuk menghemat energi, namun dapat menimbulkan harmonik yang dapat mempengaruhi kualitas daya listrik. Penelitian ini menganalisis kinerja dan harmonik motor induksi 3 fase dengan VFD pada BFWP di PT. Cahaya Fajar Kaltim menggunakan ETAP 19.0.1. Metode penelitian meliputi studi literatur, pengumpulan data, dan simulasi. Hasil simulasi menunjukkan, dengan penambahan VFD tidak berdampak signifikan pada efisiensi motor, namun menghasilkan distorsi harmonik sebesar 8,52% pada tegangan dan 9,29% pada arus. Pemasangan bank kapasitor berhasil menekan distorsi harmonik tegangan menjadi 3,61%, namun distorsi harmonik arus meningkat menjadi 10,71%. Nilai harmonik ini masih berada di bawah batas aman standar IEEE 519-2014
Implementasi Deteksi Tepi Iris Mata pada Citra Mata Normal dan Kolesterol
Authors: Rian Rahmawati Eba , Utari Evrita Lusiana , Listyalina Latifah
Published: November 2024

Deteksi tepi bertujuan untuk menyoroti bagian-bagian penting dalam citra dan memperbaiki detail yang kabur karena kerusakan atau efek akuisisi data. Sebagian besar informasi penting dalam citra berada pada batas antara dua wilayah yang berbeda. Dalam citra medis, deteksi tepi berfungsi untuk menandai detail penting, seperti kontur organ, jaringan, atau struktur lainnya yang relevan. Ini sangat penting karena informasi berharga sering ditemukan pada perbatasan antara dua area yang berbeda, seperti antara tumor dan jaringan sehat atau antara berbagai lapisan organ. Proyek akhir ini menggunakan antarmuka pengguna grafis (GUI) dan menerapkan metode Prewitt dan Canny. Pengambilan gambar mata dilakukan dengan kamera Webcam dan diproses pada tahap preprocessing dengan mengubah gambar menjadi tampilan grayscale serta menggunakan dua metode tersebut, yaitu "Prewitt" dan "Canny". Kesimpulannya, metode Canny memberikan hasil deteksi tepi terbaik karena menghasilkan morfologi garis yang lebih baik terlihat pada tepi gambar. Garis-garis vertikal dan horizontal pada bagian depan objek juga tampak lebih jelas dibandingkan dengan metode lainnya
A Comprehensive Exploration of Agents Targeting Tumor Microenvironment: Challenges and Future Perspectives
Authors: Lopes Carlos Diego Holanda , Braganca Xavier Camila , Torrado Carlos , Veneziani Ana Carolina , Megid Thais Baccili Cury
Published: November 2024

The tumor microenvironment (TME) encompasses the complex and diverse surroundings in which tumors arise. Emerging insights highlight the TME's critical role in tumor development, progression, metastasis, and treatment response. Consequently, the TME has attracted significant research and clinical interest, leading to the identification of numerous novel therapeutic targets. Advances in molecular technologies now enable detailed genomic and transcriptional analysis of cancer cells and the TME and the integration of microenvironmental data to the tumor genomic landscape. This comprehensive review discusses current progress in targeting the TME for drug development, addressing associated challenges, strategies for modulating the pro-tumor microenvironment, and the discovery of new targets.
El lugar de la ciudad sana en la defensa de Sócrates de la justicia: República I-II
Authors: Gerena Carrillo Luis Alonso
Published: November 2024

En este trabajo se sostiene que el comentario despectivo de Glaucón de que en la ciudad sana vivirían mejor los cerdos se tiene que entender con base en la clasificación de bienes que hace al inicio de su intervención, señalando de este  modo que en la ciudad sana no hay bienes que sean  agradables por ellos mismos, lo cual significa que no hay actividades que permitan un elogio de la justicia por sí misma (cf. 358d), en el que se distinga lo que parece justo de lo que es realmente justo (cf. 367c). Por esto Sócrates abandona la ciudad sana y lleva a cabo su defensa de la justicia en la ciudad enferma.
Filosofía política epicúrea: seguridad, justicia y tranquilidad. A propósito de la publicación del libro de Javier Aoiz y Marcelo Boeri
Authors: Costa Ivana
Published: November 2024

El texto proporciona un estudio crítico del libro Theory and Practice in Epicurean Political Philosophy: Security, Justice and Tranquility (Javier Aoiz y Marcelo Boeri, 2023), enfatizando algunas líneas de contacto entre Platón y el epicureísmo que allí se proponen, especialmente a propósito del problema de si un sabio epicúreo vulneraría las leyes si supiera que no va a ser descubierto
Deep Learning for CAD Prediction: X-ray Angiography Insights
Authors: Srivastava Sankalp , Matura Rishi , Sharma Sudhanshu , Hitesh  , Singh Chanpreet
Published: November 2024

This study presents a deep learning-based approach to improve the prediction of coronary artery disease (CAD) using X-ray angiography images. The primary objective is to achieve accurate and automated CAD identification by employing a convolutional neural network (CNN) model. The methodology involves preprocessing the dataset through normalization and augmentation techniques and utilizes a U-Net architecture for precise detection of coronary stenosis. To ensure robustness and generalizability, hyperparameter tuning and dropout regularisation are applied during model training. The proposed model achieves high performance, with an average Dice coefficient of 0.57 and a Jaccard Index of 0.47 on a held-out test set, indicating its effectiveness in segmenting coronary artery stenosis. These findings support the integration of deep learning methods into clinical workflows for enhanced CAD diagnosis and early intervention.
LESÕES DE PELE EM ATLETAS: IDENTIFICAÇÃO, PREVENÇÃO E TRATAMENTO
Authors: Jorge Albernaz Maria Carolina , Frazão Luiz Felipe Neves , De Souza Lopes Pedro Henrique , Martins Freires Vitor Hugo , De Moura Azevedo João Victor Bezerra , Limirio Silva Gabriela Elias , Fontes de Oliveira Jobiany Rocha , Rabelo Velloso Bruna Renata , Junqueira Bersani Marco Antônio , Oliveira Santos Brenda De , Daniel Zanoni Rodrigo
Published: November 2024

A revisão tem como objetivo destacar as principais patologias dermatológicas que afetam atletas, além de abordar estratégias de prevenção dessas condições. Trata-se de uma revisão narrativa de caráter crítico e analítico, na  pesquisa  sobre os principais  conceitos  no que tange às principais patologias dermatológicas que afetam os atletas. Foi  realizada  uma  revisão  de  artigos  nas  bases  de  dados   Scientific  Electronic  Library  Online (SciELO) e PubMed, com os seguintes Descritores em Ciências  da  Saúde  (DeCS): Atletas; Doença de pele; Esporte. Diversas lesões dermatológicas estão vinculadas à prática esportiva. As principais lesões podem ser categorizadas em quatro subgrupos: neoplásicas, mecânicas, inflamatórias e secundárias a alterações nutricionais. A prática regular de atividade física é conhecida por reduzir o risco de diferentes tipos de câncer; no entanto, quando realizada sob exposição solar prolongada, especialmente em horários de alta incidência de radiação ultravioleta (RUV) e com uso de vestuário leve, pode aumentar a probabilidade de câncer de pele. Atletas envolvidos em esportes aquáticos, como natação, surfe, canoagem e vela, enfrentam um risco adicional devido à maior refletividade da água e da areia. Embora os benefícios da prática esportiva sejam amplamente reconhecidos, sua realização sem as devidas medidas de proteção pode resultar no surgimento de patologias cutâneas. Traumas mecânicos, exposição a agentes ambientais e infecciosos, contato com a pele de outros atletas e a alimentação desses indivíduos estão associados ao desenvolvimento de dermatoses.
LESÃO PULMONAR ASSOCIADA AO USO DE CIGARRO ELETRÔNICO (EVALI): CARACTERÍSTICAS E REPERCUSSÕES
Authors: Brito Douglas Guimarães , Farias Siqueira Lowhana , Barradas Jéssica Lima , Costa Maria Clara da Cunha Mendes , Siqueira Vanessa Greiner , Oliveira Vanessa de Arêa Leão Ramos , Peixoto dos Santos Isabell , Alves Luciana Rocha , Moreira Gabriel Chagas , Neto José Gumercindo de Vasconcelos , Gomes Breno Freitas , Neto Epitácio Fernandes de Mesquita
Published: November 2024

O uso de cigarros eletrônicos aumentou nos últimos anos e foi promovido pela mídia como uma alternativa menos prejudicial aos cigarros tradicionais. No entanto, o aumento de lesões pulmonares associadas à utilização destes dispositivos, denominada EVALI, tem causado grande preocupação nos cuidados de saúde em virtude do grande impacto social e físico aos envolvidos. Existem muitos fatores que proporcionam a descrita lesão, incluindo a presença de toxinas e alterações de difícil acompanhamento na composição do produto, em virtude da vasta variedade no mercado. Pesquisas recentes mostram que produtos que contêm tetrahidrocanabinol (THC) e acetato de vitamina E estão notadamente associados a estas condições.
USO DO PARACETAMOL DURANTE A GRAVIDEZ E O DESENVOLVIMENTO NEUROLÓGICO INFANTIL
Authors: Carvalho Filho Glauber Pablo Soriano De , Salaroli Robson
Published: November 2024

O paracetamol é amplamente utilizado para tratar dor e febre e é considerado seguro para uso durante a gravidez. Contudo, pesquisas recentes apontam que a exposição pré-natal a este medicamento pode estar relacionada a mudanças no desenvolvimento neurológico infantil. Essas alterações incluem um risco aumentado para transtornos como TDAH (Transtorno de Déficit de Atenção e Hiperatividade) e TEA (Transtornos do Espectro Autista). Estudos epidemiológicos e experimentais sugerem que o uso do paracetamol durante a gravidez pode afetar fatores neurobiológicos, como a expressão do BDNF (fator neurotrófico derivado do cérebro) e a regulação do sistema endocanabinoide. Pesquisas, como as de Liew et al. (2014) e Brandlistuen et al. (2013), indicam que o uso prolongado do paracetamol aumenta o risco de TDAH em crianças expostas ao medicamento. Modelos animais também reforçam a hipótese de que o paracetamol pode interferir na formação neural, afetando a cognição e o comportamento social. Apesar desses achados, as pesquisas apresentam limitações, incluindo o controle insuficiente de fatores de confusão e a dependência de relatos maternos, que podem ser tendenciosos. Além disso, as diferenças nas doses e períodos de uso dificultam a determinação de uma relação causal. Revisões sistemáticas mostram que, embora a associação seja significativa, o efeito é moderado, sugerindo que fatores genéticos e ambientais também desempenham papel relevante. Portanto, embora exista uma possível associação entre o uso de paracetamol na gestação e desfechos neurológicos adversos, a causalidade ainda não é clara. É recomendável cautela no uso deste medicamento durante a gravidez, empregando a menor dose possível e por tempo limitado, sempre com orientação médica. Estudos longitudinais de alta qualidade são necessários para compreender melhor esses riscos e orientar a prática clínica.
Tendência temporal da mortalidade por suicídio no Acre e no Brasil, 2010 a 2022
Authors: Maia Raquel , Maia Kennedy , Maciel Vanízia , Bezerra Jader , Castro Antônio Clodoaldo , Cavalcante Joy , Silva Adriele , Souza Rodonilton
Published: November 2024

Este artigo tem por objetivo descrever o perfil epidemiológico e analisar a tendência temporal dos óbitos por suicídio no estado do Acre e no Brasil no período de 2010 a 2022. Trata-se de um estudo de série temporal que incluiu dados sobre óbitos  que tiveram como causa básica o suicídio coletados do Sistema de Informações sobre Mortalidade (SIM). A análise de dados incluiu o cálculo das taxas de mortalidade por suicídio; razão de sexo; análise da tendência temporal por meio de modelos de regressão linear generalizados segundo o método de Prais-Winsten; frequência absoluta e relativa de óbitos segundo variáveis selecionadas. No Acre, as taxas de mortalidade por suicídio por 100 mil habitantes variaram de 5,35 a 8,94, com tendência crescente de 4,03% ao ano (p<0,001). No Brasil, o valor mínimo e máximo da mortalidade foram observados nos anos de 2010 (5,23) e 2022 (7,72) respectivamente; houve tendência crescente com variação percentual anual (APC) de 3,16% (p<0,001). As taxas de mortalidade por suicídio foram superiores entre os homens com razão de sexo variando de 2,58 a 7,08 no Acre e 4,74 a 5,08 no Brasil. Houve crescimento estatisticamente significante da mortalidade para ambos os sexos com maior crescimento entre as mulheres no estado do Acre (APC= 6,95%). Indivíduos com escolaridade entre 8 e 11 anos e solteiros foram mais afetados. No Acre, maior incidência foi observada entre jovens de 15 a 24 anos e raça parda, enquanto no Brasil, houve predominância entre pessoas de 25 a 34 anos e raça branca. A tendência crescente de suicídios observada no Acre e no Brasil se manifesta de maneira preocupante considerando as elevadas taxas entre homens e crescimento acentuado entre as mulheres. O aumento observado contraria a tendência global de redução demandando uma reavaliação das estratégias de prevenção e promoção da saúde mental, com ênfase na criação de políticas públicas mais assertivas e equitativas, alinhadas aos desafios regionais e nacionais.
USO DE CICATRIZADOR PERSONALIZADO EM IMPLANTES IMEDIATOS: revisão de literatura
Authors: Rodrigues Izabelly , Beltrão Leticia , Muniz Emelly , Tavares Paula , Dantas Matheus , Cavalcanti Tayguara , Leão Michelle
Published: November 2024

Introdução: Eventos fisiológicos, como reabsorção óssea e perda iminente do ligamento periodontal, podem ocorrer após a exodontia. A implantação imediata surgiu com o propósito de preservar as paredes do alvéolo, mas, pode estar associado à recessão marginal. O uso de cicatrizador personalizado (CP) em implantes imediatos (IM) é uma nova alternativa para a conformação de perfil de emergência gengival, permitindo evitar a fase de coroa provisória sobre implante, reduzindo o custo de um tratamento e otimizando a modelagem dos tecidos. Objetivo: demonstrar as características do uso do CP em IIM com busca na literatura. Metodologia: Trata-se de uma revisão de literatura com onze artigos selecionados das bases de dados: PubMed, Lilacs e Google Acadêmico que possuem como avaliação principal o uso de cicatrizador personalizado em implantes imediatos. Resultados esperados: Colaborar com discussão científica a respeito do uso de cicatrizadores personalizados na implantodontia. Considerações Finais: O uso do cicatrizador personalizado proporciona possível otimização no pós-operatório do paciente, com menor perda óssea e maior previsibilidade de cicatrização tecidual final.
Risk Factors, Management, and Evolution after the First Acute Myocardial Infarction: A Real-World Study Comparing Cohorts of Women and Men in the TriNetX Network
Authors: Guida Camila Mota , Souza Eduardo Juvenal de , Costa Leandro Menezes Alves da , Scudeler Thiago Luis , Nunes Rafael Amorim Belo , Oliveira Gustavo Bernardes de Figueiredo
Published: November 2024

Abstract Background: International cohort studies have consistently demonstrated an unfavorable prognosis in female patients after the first acute myocardial infarction (AMI) over the past decades. However, national data on this topic are limited. Objectives: This study aims to compare national cohorts of men and women hospitalized due to the first acute myocardial infarction, examining long-term outcomes. Methods: A retrospective, observational study using real-world data extracted from the global TriNetX platform, including patients of both sexes with a confirmed diagnosis of AMI according to the International Classification of Diseases (ICD), version 11, code I21. The level of statistical significance adopted in the analysis was 5% (0.05). The primary outcome assessed was a composite of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up. Results: Data from 29,041 patients were evaluated, of which 11,284 (38.4%) were women. The mean age of the female and male populations was 64.4 and 59.8 years, respectively. The group of women showed a higher occurrence of the composite outcome of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up (OR 1.058; CI 1.005 - 1.113; p = 0.03). Conclusions: In this large Brazilian cohort, the female sex was associated with a higher occurrence of cardiovascular events within 5 years after hospital discharge.
Causal Relationship between Television Viewing Time, Cardiovascular Diseases, and Potential Mechanisms
Authors: Hu Mengjin , Li Boyu , Xia Jinggang , Yin Chunlin , Yang Yuejin
Published: November 2024

Abstract Background: As the predominant leisure-time sedentary behavior, television viewing was documented to increase cardiovascular diseases in observational studies, yet the causal relationship and potential mechanisms remain to be determined. Objectives: To systematically investigate the causal relationship between television viewing time, cardiovascular diseases, and potential mechanisms. Methods: We conducted a two-sample Mendelian randomization (MR) analysis to estimate causal associations with cardiovascular diseases and biomarkers of cardiometabolic risk. The random inverse-variance weighted method was used as the primary estimate. To account for multiple comparisons, a Bonferroni correction p value for cardiovascular diseases and biomarkers of cardiometabolic risk was 0.0045 and 0.0024, respectively. Results: Genetically instrumented television viewing time was associated with higher risks of type 2 diabetes (odd ratio [OR]=2.51; 95% confidence interval [CI]: 1.89-3.33; p<0.00001), hypertension (OR=2.11; 95% CI: 1.67-2.66; p<0.00001), coronary heart disease (OR=1.53; 95% CI: 1.23-1.91; p=0.00015), and heart failure (OR=1.42; 95% CI: 1.18-1.70; p=0.00017). Suggestive evidence of harmful associations was also observed for peripheral artery disease (OR=1.58; 95% CI: 1.07-2.34; p=0.02253) and ischemic stroke (OR=1.34; 95% CI: 1.10-1.63; p=0.00328). Biomarkers of cardiometabolic risk, including interleukin 10, leptin, visceral adipose, abdominal subcutaneous adipose, liver fat, body mass index, waist circumference, triglycerides, and C-reactive protein, were increased. Systolic blood pressure, heart rate, low-density lipoprotein, and total cholesterol were potentially increased while high-density lipoprotein was decreased. However, television viewing time had no effect on venous thromboembolism or pulmonary embolism. Conclusion: Television viewing time was causally associated with increased risks of cardiovascular diseases, which may be explained by metabolic and inflammatory mechanisms.
Prognostic Evaluation of Chagasic and Non-Chagasic Patients Undergoing Pacemaker Implantation and Cardiac Resynchronization in a Tertiary Center
Authors: Vasconcelos Laís Toledo de , Martins Larissa Natany Almeida , França Anna Terra , Castilho Fábio Morato de , Ribeiro Antônio Luiz Pinho
Published: November 2024

Abstract Background: Chagas cardiomyopathy (ChCC) is one of the causes of the implantation of pacemakers (PM) in many patients and has been associated with an adverse prognosis. Objectives: To compare the prognosis of the chagasic and non-chagasic populations undergoing PM and cardiac resynchronizer implantation. Methods: Observational, retrospective study, which analyzed a cohort of patients who underwent implantation of these devices, in a tertiary center, from October 2007 to December 2017, comparing the chagasic group with non-chagasic patients. The non-parametric Kaplan-Meier method was used to calculate patient survival. The significance level adopted in the statistical analysis was 5%. The primary outcome was mortality from any cause, while the secondary outcomes were the occurrence of hospitalization and the combination of hospitalization and death. Results: A total of 911 patients were included, of which 23.4% had ChCC. In a Cox analysis adjusted for sex and age, Chagas disease (ChD) was not associated with an increased risk of death (HR: 1.14, CI:95%, 0.86-1.51, p=0.365), hospitalization (HR: 0.79, CI:95%, 0.61-1.04, p=0.09) or combined outcome of death and hospitalization (HR: 0.90, CI:95%, 0.72-1 .12, p=0.49). Conclusions: ChD was not associated with an increased risk of death, hospitalization, or combined outcome of death and hospitalization, even after adjustment for sex and age. These results contrast with those of previous studies and suggest changes in the quality of care of patients with cardiomyopathy.
Associação Individual e Simultânea entre Fatores de Risco para Doença Cardiovascular e Hábitos Inadequados do Estilo de Vida em uma Amostra do Brasil
Authors: Gonçalves Letícia , Zanlorenci Suellem , Pelegrini Andreia , Lima Tiago Rodrigues de , Silva Diego Augusto Santos
Published: November 2024

Resumo Fundamento: As doenças cardiovasculares (DCV) são frequentemente influenciadas por fatores modificáveis, principalmente pelas escolhas de estilo de vida dos indivíduos, que desempenham um papel crucial na modulação do risco cardiovascular. Objetivo: Investigar a associação individual e simultânea entre comportamentos inadequados do estilo de vida e fatores de risco para DCV em adultos e idosos. Métodos: Trata-se de um estudo transversal com 1.079 usuários do Programa Academia da Saúde no Brasil. Foram investigadas individual e coletivamente informações relacionadas a dieta inadequada, consumo excessivo de álcool, tabagismo e inatividade física (0, 1 ou ≥ 2 fatores) em associação com fatores de risco para DCV (hipertensão, hipercolesterolemia, diabetes mellitus e obesidade), considerando os dois desfechos seguintes: presença de fatores de risco para DCV e número de fatores de risco para DCV presentes no mesmo indivíduo (0, 1, 2 ou ≥ 3 fatores de risco). Foram utilizadas análises de regressão logística e multinomial. A significância estatística adotada foi de 5%. Resultados: Um maior número de comportamentos do estilo de vida inadequados foi associado a maiores chances de presença simultânea de 1, 2 ou ≥ 3 fatores de risco de DCV. A adoção simultânea de 1 e ≥ 2 comportamentos de estilo de vida inadequados foi associada a maiores chances de hipercolesterolemia. A adesão simultânea a ≥ 2 comportamentos de estilo de vida inadequados foi associada a menores chances de hipertensão. Conclusão: Um maior número de comportamentos de estilo de vida inadequados foi associado a maiores chances de presença simultânea de múltiplos fatores de risco de DCV.
Individual and Joint Association between Cardiovascular Disease Risk Factors and Inadequate Lifestyle Behaviors in a Sample from Brazil
Authors: Gonçalves Letícia , Zanlorenci Suellem , Pelegrini Andreia , Lima Tiago Rodrigues de , Silva Diego Augusto Santos
Published: November 2024

Abstract Background: Cardiovascular diseases (CVD) are often influenced by modifiable factors, notably individuals’ lifestyle choices, which play a crucial role in modulating cardiovascular risk. Objective: To investigate the individual and simultaneous association between inadequate lifestyle behaviors and risk factors for CVD in adults and older adults. Method: A cross-sectional study with 1079 users of the Health Academy Program in Brazil. Information related to inadequate diet, excessive alcohol consumption, smoking, and physical inactivity were individually and collectively investigated (0, 1, or ≥ 2 factors) in association with CVD risk factors (hypertension, hypercholesterolemia, diabetes mellitus, and obesity), considering the following two outcomes: presence of CVD risk factors and number of CVD risk factors present in the same individual (0, 1, 2, or ≥ 3 risk factors). Logistic and multinomial logistic regression analyses were used. The statistical significance adopted was 5%. Results: A higher number of inadequate lifestyle behavior was associated with greater odds of simultaneous presence of 1, 2, or ≥ 3 CVD risk factors. The simultaneous adoption of 1 and ≥ 2 inadequate lifestyle behaviors was associated with greater odds of hypercholesterolemia. Simultaneous adherence to ≥ 2 inadequate lifestyle behaviors was associated with lower odds of hypertension. Conclusion: A greater number of inadequate lifestyle behaviors was associated with higher odds of simultaneous presence of multiple CVD risk factors.
Endomyocardial Biopsy Using Rigid Bioptome Technique and the Risk of Tricuspid Regurgitation after Heart Transplantation
Authors: Beck-da-Silva Luís , Bridi Leonardo Hennig , Matte Bruno S. , Valle Felipe Homem
Published: November 2024

Abstract Endomyocardial biopsy (EB) is the preferred procedure for post-heart transplant rejection diagnosis. The rigid bioptome technique has been used due to its greater simplicity and has been criticized for the potential risk of tricuspid regurgitation (TR). We aimed to review all the EBs performed by this technique in a tertiary center and estimate the rate of complications and/or aggravation of TR. Cross-sectional, retrospective, anterograde study. Data were collected from 729 EBs performed in 55 post-heart transplant patients with a rigid Scholten Novatome™ bioptome between September 2012 to March 2022. All EBs were performed via the right jugular vein under local anesthesia and through micro-puncture and ultrasound guidance. A total of 729 procedures had an echocardiography performed before and after the procedures. The estimate of TR was categorized as absent, minimal, mild, moderate, and severe. McNemar's chi-square test was used to analyze the degree of pre- and post-EB TR. There was a worsening enough to become moderate or severe post-biopsy TR in two (0.27%) procedures, and there was a slight change in TR from minimal to mild TR in 25 (3.42%) procedures. In 729 percutaneous EBs performed with a rigid bioptome, there was no myocardial perforation, cardiac tamponade or pneumothorax. One death occurred within 24 hours after the procedure for an unknown reason. EB using a rigid bioptome is safe and has not been associated with worsening TR in a follow-up of 729 EBs performed after cardiac transplantation. The overall complication rate, including moderate to severe TR, was 0.81%. The mortality rate was 0.14%.
Escores de Risco Poligênico: O Próximo Passo para Melhorar a Estratificação de Risco na Doença Arterial Coronariana?
Authors: Stein Ricardo , Ferrari Filipe , García-Giustiniani Diego
Published: November 2024

Resumo Apesar dos avanços significativos no tratamento da doença arterial coronariana (DAC) e das reduções nas taxas de mortalidade anuais nas últimas décadas, a DAC continua sendo a principal causa de morte no mundo. Consequentemente, há uma necessidade contínua de esforços para abordar essa situação. Os algoritmos clínicos atuais para identificar pacientes em risco são particularmente imprecisos para indivíduos de risco moderado. Por esse motivo, foi sugerido que são necessários testes auxiliares, incluindo triagem genética preditiva. À medida que os estudos genéticos se expandem rapidamente e os dados genômicos se tornam mais acessíveis, diversos escores de risco genético têm sido propostos para identificar e avaliar a suscetibilidade de um indivíduo ao desenvolvimento de doenças, incluindo a DAC. De fato, o campo da genética tem contribuído substancialmente para a previsão de risco, particularmente nos casos em que as crianças têm genitores com DAC prematura, resultando em um risco aumentado de até 75%. Os escores de risco poligênico (PRSs, do inglês polygenic risk scores) surgiram como uma ferramenta potencialmente valiosa para compreender e estratificar o risco genético de um indivíduo. O PRS é calculado como uma soma ponderada de variantes de nucleotídeo único presentes em todo o genoma humano, identificáveis por meio de estudos de associação genômica ampla, e associadas a várias doenças cardiometabólicas. O uso dos PRSs é promissor, pois permite o desenvolvimento de estratégias personalizadas para prevenir ou diagnosticar patologias específicas de forma precoce. Ademais, seu uso é capaz de complementar os escores clínicos existentes, aumentando a precisão da previsão de risco individual. Consequentemente, a aplicação dos PRSs tem o potencial de impactar positivamente os custos e os desfechos adversos associados à DAC. A presente revisão narrativa oferece uma visão ampla do papel dos PRSs no contexto da DAC.
UX Maturity in Southeast Brazilian Companies
Authors: Comuniam Kalle Ana Caroline , Frogeri Rodrigo Franklin
Published: November 2024

User Experience (UX) refers to all interactions users have with a product or service, from the initial impression to its actual use. UX maturity assesses an organization’s ability to effectively deliver user-centered design. Organizations with a higher level of UX maturity are better able to provide products that align with their customers' needs. However, reaching UX maturity is challenging, requiring strategic, cultural, and procedural changes. This study aimed to assess the UX maturity of companies in the Southeast region of Brazil from the perspective of their managers. The study follows a qualitative approach, with interviews conducted with 10 UX managers. The analysis and classification of the organizations' UX maturity were based on the Nielsen Norman Group model. Results showed that the "Structured" and "User-Driven" maturity levels are the most common in these organizations. This indicates that while UX practices are generally well-organized, there are still challenges in reaching a level of maturity where users are central to all decision-making.
The The Relationship Between Consumption of Blood Supplemental Tablets to the Incidence of Anemia in Adolescent Women
Authors: Sudarti Fitri , Bahriyah Fitriyani , Putri Monifa
Published: November 2024

Adolescent girls are a group that is prone to anemia. In Indonesia, the incidence of anemia is still quite high. This is influenced by the habit of consuming iron tablets that are not optimal. This study aims to determine the relationship of compliance with blood supplement consumption tablets to the incidence of anemia in female adolescents. The method used is analytic with a cross sectional approach. Using a total sampling technique, 113 final year adolescents attending SMK N 1 Rengat were used as research respondents. Data were analyzed using the chi-square test. Based on the results of the study, the adherence of adolescents in consuming iron tablets was disobedient, namely 75.2%. The majority of young women have anemia, amounting to 66.4%. It can be concluded that there is a relationship between adherence to taking iron tablets and the incidence of anemia in young women at Rengat 1 Public Vocational School in 2022 with a p-value of 0.00
The The Utilization of International Subscription E-Journals in Supporting Research on Stunting
Authors: Oktariani Falinda , Aisyah Siti
Published: November 2024

This study investigates the utilization of international e-journals for stunting-related research at Poltekkes Kemenkes Riau. The purpose is to uncover insights into how students interact with international e-journals about stunting, identify challenges, and assess the librarian's role in promoting awareness. Employing in-depth interviews, the research gathers data thematically to gain a profound understanding of these dynamics. The findings highlight students' limited familiarity with international e-journals, primarily due to language barriers and a lack of guidance. However, librarians play a pivotal role in fostering awareness of these resources. The study concludes by emphasizing the significance of collaboration between librarians and students, supported by initiatives aimed at enhancing access and language proficiency. This collaborative approach holds the potential to invigorate the use of international e-journals for stunting-related research and contributes to the broader knowledge domain.
Education Of Knowledge And Basic Life Support Training For Teenage Students
Authors: Syahferi Anwar  , Tanjung Dudut , Damanik Balqis Nurmauli , Sianturi Marta Imelda Br , Lubis Izmi Arisa Putri , Padang Alisarjuni
Published: November 2024

Individuals and groups, including the general public, are currently required to be able to provide immediate assistance when facing emergency conditions. To ensure assistance is provided according to proper procedures, it is necessary to offer training on Basic Life Support (BLS). Students of SMK Kesehatan Haji Sumatera Utara, who are teenagers with significant potential, are ideal candidates for such training. Although they are organized into a KKR Cadre Team or Youth Health Cadre group, they currently lack the necessary knowledge and need to be equipped with BLS skills. The purpose of this service is to enhance the knowledge and technological capabilities of students at SMK Kesehatan Haji Sumatera Utara regarding Basic Life Support in emergency cases. The method used includes interactive lectures, questions and answers, pre-tests, interventions, and post-tests. The results of the counseling and training showed a marked improvement in knowledge about Basic Life Support and an increase in the skills required to administer BLS. It is essential to carry out continuous counseling and socialization efforts within the school, particularly in the area of Basic Life Support
Comparative Analysis of Multicriteria Inventory Classification and Forecasing: A Case Study in PT XYZ
Authors: Purwandaru Dhanang , Ruldeviyani Yova , Nugraheni Sani , Prisillia Galuh
Published: November 2024

One crucial aspect of supply chain management is inventory management. Inefficient inventory management can lead to various issues, such as product expiration, where a high number of items in the warehouse either have expired or are approaching expiration. This issue is experienced by a distribution SME in Indonesia, PT XYZ. Without such classifications, it becomes challenging to predict demand and manage stock levels efficiently. Therefore, the aim of this study is to classify inventory to identify the most important items to business and make a forecasting model of sales quantity to predict inventory replenishment using machine learning algorithms. To advance our research, we adopted the Cross Industry Standard Process for Data Mining (CRISP-DM) methodology. For inventory classification, we conducted a hybrid approach that combined TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) and ABC analysis (A: high-value items, B: medium-value items, and C: low-value items). The data employed in this study comprised secondary data, including purchase orders, sales orders, and stock movement records. The result reveals that 11 of the total 383 items under class A are important items for business. After obtaining labels from the ABC Analysis, we proceed to train models using KNN, SVC, and Random Forest for predicting inventory classification. Notably, the Random Forest model showcased remarkable performance and outperformed the rest of the models, achieving an accuracy of 99.21%. For inventory forecasting ARIMA displays a competitive performance with RMSE value 5.305 and MAE value 3.476, indicating a relatively accurate prediction with lower forecasting errors than two other models
Numerical Treatment for the Distributed Order Fractional Optimal Control Coronavirus (2019-nCov) Mathematical Model
Authors: Alsenaideh Nehaya R. , Al-Mekhlafi Seham M. , Hassan Saleh M. , Radwan Abdelaziz E. , Sweilam Nasser H.
Published: November 2024

In this paper, we presented the distributed order fractional optimal control of the Coronavirus (2019-nCov) mathematical model. The distributed order fractional operator is defined in the Caputo sense. Control variables are considered to reduce the transmission of infection to healthy people. The discretization of the composite Simpson's rule and Grünwald-Letnikov nonstandard finite difference method is constructed to solve the obtained optimality system numerically. The stability analysis of the proposed method is studied. Numerical examples and comparative studies for testing the applicability of the utilized method and to show the simplicity of this approximation approach are presented. Moreover, by using the proposed method we can conclude that the model given in this paper describes well the confirmed real data given in Spain and Wuhan.
Enhancing playful interactions: eCoaching mothers of preschool children with disabilities
Authors: Passmore Amanda H. , Tejero Hughes Marie
Published: November 2024

Pretend play is crucial for developing communication and cognitive skills in preschool children. Targeted coaching during pretend play can effectively support family-centered practices and home-based assistance. This study employed a detailed collective case study to explore how eCoaching can aid family-centered practices during at-home pretend play for children with speech-language and developmental delays. Two mother-child pairs, each involving a preschool child with an Individual Education Plan (IEP), participated in at-home eCoaching sessions while engaging in pretend play. Implementing eCoaching helped mothers acquire play-based knowledge and better facilitate pretend play tailored to their child's developmental needs. Throughout the eCoaching process, improvements were noted in the children's quality of pretend play and language behaviors. After the eCoaching sessions concluded, both mothers and children experienced benefits from the process. The mothers had positive perceptions of their eCoaching sessions, found them easy to implement, and considered eCoaching beneficial for themselves and their children. This indicates that eCoaching is a socially valid family-centered practice. Future research should investigate how individual variables associated with the eCoaching influence child and family outcomes.
Hubungan kelelahan dengan kejadian depresi pada mahasiswa kedokteran semester 7 di Universitas Palangka Raya
Authors: Martha Furi Lewi , Br Surbakti Ranintha , Nuryagus Siringo Yulinar , Pradnya Paramita Parameswari
Published: November 2024

Fatigue can be defined as a feeling of lack of energy and difficulty in initiating or maintaining spontaneous activities.  Fatigue is a growing problem among medical students. A common reason for fatigue in medical students is excessive academic workload. In recent years, fatigue has been linked to stress which can lead to depression. Therefore, this study aims to examine the relationship between fatigue and the incidence of depression in 7th semester medical students at Palangkaraya University. This research is an observational study with a cross sectional research design. which data were taken using a questionnaire from 140 respondents using purposive sampling technique. Statistical analysis using Spearman. The results of statistical analysis showed that of 140 respondents with an age range of 20 – 23 years, 82 respondents (58.57%) experienced significant fatigue. There were 93 respondents (66.43%) experiencing minimal depression, 24 respondents (17.14%) experiencing mild depression, 16 respondents (11.43%) experiencing moderate depression and 7 respondents (5%) experiencing severe depression. From the results of the hypothesis test, it was found that there was a relationship between fatigue and the incidence of depression with a value of p = 0.001. This research shows there is a statistically significant relationship between fatigue and depression.
Skrining fitokimia tumbuhan potensi obat kanker kolorektal Begonia medicinalis Ardi & D.C. Thomas
Authors: Ardiputra Muh. Akbar , Musjaya M. Guli  , Andi Saifah  , Santi  , Bambang Sardi  , Wafiq Nurfadilah  , Mohammad Rivaldi Putra Pratama  , Afifah Islamia
Published: November 2024

Cancer is a condition in which cells or tissues undergo abnormal progressive growth. Colorectal cancer is cancer that occurs in the colon to rectum organs of humans. Alternative therapy for colorectal cancer treatment is the use of herbs such as Begonia medicinalis Ardi & D.C. Thomas. This study aimed to screen the bioactive compounds in the Begonia medicinalis Ardi & D.C. Thomas. extract and its potential as a colorectal cancer drug. This research consists of two stages, namely the extraction stage using the maceration method and the screening stage. The results showed that the extract of Begonia medicinalis Ardi & D.C. Thomas. positively contains flavonoids, alkaloids, and saponins. These bioactive compounds have potential activity as preventive and curative agents for colorectal cancer through several mechanisms, including suppressing oxidative stress, inhibiting CDK activity, suppressing intestinal inflammation, and increasing floranormal diversity and probiotic barrier activity in the intestine.
Pengetahuan kecacingan menggunakan media video pada siswa sekolah dasar
Authors: Sahariyani Menik , Sari Rita Kartika , Tasyahuri Syabila Aldiffah
Published: November 2024

Helminthiasis in children still occurs in Seren Rembang. Educational video can enhance knowledge and attitudes in order to reduce the morbidity of Helminthiasis.  This study aims to determine the impact of providing Helminthiasis educational video on the level of knowledge and attitude of students at SDN Seren Rembang. Research method is Quasi Experimental using a "pre-post test one group only" design. Total sampling involved 37 students of SDN Seren Rembang. Two questionnaires utilized to measure the knowledge and the attitude. Data analysis using the Paired Sample t-test. Result : Educational video is able to increase the average level of students' knowledge and attitude from 4.43 into 7.75, and from 30.43 into 33.37, respectively. Paired samples t-test is significant for both knowledge (p = 0,000), and attitude (p = 0,002). This study conclude that providing Helminthiasis educational video affect the level of knowledge and attitude of students at SDN Seren Rembang.
Tingkat Pengetahuan, Skill Dan Pelatihan Terhadap Kinerja Karyawan Pada Rumah Sakit XYZ Di Surabaya
Authors: Irba Salsalbilah Athillah , Hidayat Arif
Published: November 2024

Penelitian ini berfokus pada tantangan yang dihadapi oleh organisasi, khususnya rumah sakit, dalam meningkatkan kinerja karyawan, karena di dunia yang semakin kompetitif, kinerja karyawan menjadi salah satu indikator utama keberhasilan organisasi. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengetahuan, keterampilan, dan pelatihan mempengaruhi kinerja karyawan secara parsial maupun simultan. Selain itu, penelitian ini bertujuan memberikan masukan kepada manajemen Rumah Sakit XYZ di Surabaya mengenai pengembangan sumber daya manusia. Penelitian ini menggunakan metode kuantitatif dengan pengambilan sampel menggunakan Simple Random Sampling dan rumus Slovin, di mana 86 responden dipilih dari 638 karyawan. Metode analisis yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa pengetahuan, keterampilan, dan pelatihan masing-masing berpengaruh signifikan terhadap kinerja karyawan, baik secara parsial maupun simultan.
Dispersi Kepemilikan, Pertumbuhan Penjualan, dan Kesulitan Keuangan terhadap Kebijakan Dividen yang Dimoderasi oleh Ukuran Perusahaan
Authors: Alfiana Siti Tina , Ardhani Lutfi
Published: November 2024

Indonesia merupakan negara kepulauan terbesar di dunia memiliki keindahan alam yang menjadi daya tarik utama bagi wisatawan, baik lokal maupun mancanegara. Sektor pariwisata mengalami kenaikan kunjungan wisata yang signifikan. Hal ini terbukti dengan perolehan peringkat ke-32 oleh Indonesia dalam Travel and Tourism Development Index (TTDI) pada tahun 2022. Adanya peningkatan dalam jumlah kunjungan wisatawan domestik maupun internasional memberikan sinyal positif bagi potensi pengembangan bisnis di sektor pariwisata. Investor melihat peluang besar dalam berbagai segmen, termasuk pengembangan resor, hotel, restoran, dan infrastruktur transportasi. Tujuan dari riset ini adalah untuk mengetahui pengaruh dispersi kepemilikan, pertumbuhan penjualan, dan kesulitan keuangan terhadap kebijakan dividen yang dimoderasi oleh ukuran perusahaan. Metode yang digunakan adalah kuantitatif dengan menggunakan purposive sampling. Software STATA digunakan untuk mengolah data. Temuan dari penelitian mengindikasikan bahwa hanya dispersi kepemilikan yang berpengaruh terhadap kebijakan dividen. Ukuran perusahaan hanya mampu memoderasi dispersi kepemilikan terhadap kebijakan dividen.