bluuebunny/crossref_metadata_2025 huggingface dataset:
Dimensional Analysis Demystified — Navigating the Universe through Dimensions
Authors: Thakur Soumendra Nath
Published: November 2023

Dimensional analysis is a powerful tool for unraveling the fundamental relationships that govern the physical world. This paper takes a comprehensive journey through the concept of dimensions, their powers, and the intriguing transitions between them. These dimensions, including length, width, height, and time, are the building blocks of our physical reality. By exploring the shift between lower and higher dimensions, new attributes and powers emerge, enriching our understanding of the cosmos.

This study delves into the mathematics behind quantum mechanics and quantum gravity, emphasizing the connections between energy, length scales, and fundamental constants. Notably, it elucidates the role of the fourth dimension, often associated with time. Through careful analysis, this paper demonstrates the prowess of dimensional analysis as a tool to investigate the relationships between dimensions and their significance in mathematical and physical equations.

In summary, this work aims to demystify dimensional analysis, presenting its applications, and revealing the insights it offers into the bedrock of the laws governing the universe.
H. Maiboroda National Honoured Bandura Choir of Ukraine: History of Functioning and Priority Principles of Creativity
Authors: Kubik Olha
Published: November 2023

The purpose of the article is to identify the leading trends in the activity of one of the oldest professional creative teams – the H. Maiboroda National Honoured Bandura Choir of Ukraine in the context of the development of academic folk vocal and instrumental art. The research methodology is determined by general philosophical, dialectical and historical principles, systematic and comparative approaches, as well as special musicological methods for the study of bandura instruments, concert and touring activities, repertoire formation trends, and personological aspects of musical creativity. The scientific novelty of the article is a systematic analysis of the creative activity of the H. Maiboroda National Honoured Bandura Choir through the prism of academicisation of folk vocal and instrumental art, development of ensemble bandura performance, selection and optimisation of bandura instruments, formation of repertoire principles, contribution of leading directors and conductors of the band to its professional formation, cooperation with composers and soloists, and the thematic principle in organising concert and touring programmes. Conclusions. The H. Maiboroda National Honoured Bandura Choir of Ukraine is a unique collective with a rich history, accumulation and synthesis of both folk music traditions – kobzarism and academic choral traditions. More than a century of the choir's functioning has become an expression of the cultural peculiarities of the time periods of bandura creativity and performance: at the level of improving the instrumentation, involving other folk and academic instruments in banduras, selecting male voices, choosing the texture of choral singing and instrumental playing, genre and thematic directions of the repertoire, collaborating with soloists and conductors, and a wide geography of concert and touring activities. The priority directions of the repertoire of the choir are folklore samples in a cappella and vocal-instrumental representation and composer's elaboration, original works and arrangements of Ukrainian and foreign composers, covering historical, Cossack, lyrical, humorous, riflemen's songs, Shevchenko's songs, UPA songs, and modern patriotic works.

Keywords: bandura art, folk vocal and instrumental art, collective folk and instrumental art, bandura ensemble, bandura chapel, academisation, repertoire, composers' works, concert activity.
The Relations Between Breast Cancer and Hormonal Contraception Acceptor At RSUP Dr. Mohammad Hoesin Palembang in 2021
Authors: Sabrina Nur Nabila , Manan Heriyadi , Putra Hadrians Kesuma
Published: November 2023

Introduction. Breast cancer is a non-communicable disease that has become a health problem in the world. One of the risk factors for breast cancer is hormonal factors that can be obtained from the use of hormonal contraception. This study describes the relationship between the incidence of breast cancer and the use of hormonal contraception at RSUP Dr. Mohammad Hoesin Palembang in 2021.
Method. This is an observational analytic study with a case-control design. The data used are secondary data and primary data. The sample are women with breast cancer and benign breast tumors at RSUP Dr. Mohammad Hoesin Palembang in 2021who met the inclusion criteria.
Results. There was a significant relationship between the use of hormonal contraceptives (p = 0.003), duration of the use of hormonal contraceptives>5 years (p = 0.004), the type of injectable hormonal contraceptive (p = 0.001), the type of hormonal pills (p = 0.018) and a family history (p = 0.001). Meanwhile, there was no significant relationship between the type of hormonal contraceptive implant (p = 0.724), parity (p = 1.000), and age at menarche (p = 0.129),with the incidence of breast cancer.
Conclusion. There is a significant relationship between the use of hormonal contraception, duration of use of hormonal contraception >5 years, type of injectable hormonal contraceptive use, type of use of hormonal contraceptive pills, and family history of breast cancer with breast cancer incidence.
Computational Group Theory and Quantum-Era Cryptography
Authors: John Michael N. , O. G. Udoaka
Published: November 2023

This paper provides an overview of the significant role of computational group theory in cryptography. Group theory plays a crucial role in various cryptographic applications, such as key exchange, encryption, and digital signatures. This paper examines the fundamental concepts, algorithms, and applications of computational group theory in cryptography, using polycyclic groups with a focus on key findings and recent developments in quantum-era cryptography.
VOLATILITAS HARGA JAMBU KRISTAL DI KABUPATEN KEBUMEN
Authors: Imade Yoga Prasada  , Wibisonya Irawan , Saridewi Larasati Puspita , Anisya Ayu Putri Merry
Published: November 2023

Kebumen merupakan salah satu sentra penghasil komoditas jambu kristal. Hal ini didorong oleh tingginya produksi dan produktivitas jambu kristal di Kabupaten Kebumen. Meskipun demikian, pergerakan harga komoditas jambu kristal di tingkat petani masih sangat tinggi. Oleh karena itu, penelitian ini dilakukan untuk mengetahui volatilitas harga jambu kristal di tingkat petani di Kabupaten Kebumen. Data yang digunakan pada penelitian ini merupakan data sekunder yang bersumber dari Badan Pusat Statistik. Data selanjutnya dianalisis dengan menggunakan model ARCH-GARCH. Hasil analisis menunjukkan bahwa harga jambu kristal di tingkat petani di Kabupaten Kebumen memiliki volatilitas yang tinggi. Selain itu, harga jambu kristal di tingkat petani juga cenderung sensitive terhadap guncangan harga.
Tinjauan Maqashid Syari’ah Terhadap Pembangunan Bendungan Di Desa Wadas
Authors: Muhammad Kamal
Published: November 2023

Penelitian ini dilatar belakangi oleh rencana pembangunan bendungan di desa Wadas Kecamatan Bener Kabupaten Purworejo. rencana pertambangan batuan andesit di Desa Wadas sebagai bahan material Proyek Strategis Nasional (PSN) Bendungan. Rencana pertambangan ini memerlukan lahan seluas 462,22 hektar yang terletak di Desa Guntur, Kecamaran Bener, Purworejo. Selain itu, proyek ini akan memotong bukit di wilayah tersebut dan hancurnya ekosistem sekitar. Maka dari itu, pelaksanaan pembangunan harus dilakukan dengan memperhatikan maslahat. Mengingat kebijakan pembebasan tanah justru menyebabkan hilangnya sumber mata pencaharian dan kerusakan lingkungan. konstruk maqasid syari’ah menyatakan kemaslahatan yang meliputi penjagaan terhadap 5 hal (kulliyyah al khams). Pembangunan menempatkan manusia sebagai tujuan akhir pembangunan dalam rangka menciptakan lingkungan yang memungkinkan rakyat untuk menikmati umur panjang, sehat, dan menjalankan kehidupan dengan produktif. Bahasan tentang tujuan shariah (maqashid  al-shariah) menarik  untuk  kemudian dijadikan  alat  analisis  dalam  mendekati  kajian  tentang pembangunan bendungan.
ВПЛИВ ЗАСОБІВ ФІЗИЧНОЇ ТЕРАПІЇ НА ПОКРАЩЕННЯ ПСИХОЕМОЦІЙНОГО СТАНУ ПАЦІЄНТІВ ІЗ РЕВМАТОЇДНИМ АРТРИТОМ
Authors: Ногас А. О.
Published: November 2023

У статті наведені дані щодо поширеності захворювання на ревматоїдний артрит. Встановлено, що висока ураженість осіб працездатного віку, швидка інвалідизація хворих представляє серйозну медико-соціальну проблему та спричиняє величезні економічні витрати. Досліджено, що хронічний, прогресуючий процес захворювання призводить до формування в пацієнтів психоемоційних порушень, які негативно впливають на якість їхнього життя. Мета роботи – оцінити ефективність впливу засобів фізичної терапії на психоемоційний стан пацієнтів із ревматоїдним артритом. Матеріал та методи. Обстежено 188 пацієнтів із ревматоїдним артритом, із них жінок – 156 (83 %), чоловіків – 32 (17 %), середній вік яких склав 45 років. Усі хворі були розподілені методом рандомізації на контрольну (n = 92) та основну (n = 96) групи. З метою оцінки ефективності впливу засобів фізичної терапії на психоемоційний стан пацієнтів із ревматоїдним артритом нами проведено анкетування з використанням Госпітальної шкали тривоги і депресії HADS. Результати. До технології реабілітаційних заходів належали: терапевтичні вправи, лікувальний масаж, самомасаж, ортезування, фізіотерапевтичні процедури, гідротерапія, кінезіотейпування, механотерапія. Проводили психологічну підтримку пацієнтів, застосовували аутогенне тренування та позитивну психотерапію. Первинне обстеження показало, що в більшості пацієнтів із ревматоїдним артритом (86 %) спостерігаються психоемоційні порушення тривожного та депресивного характеру, що підтверджує дані різних авторів. Представлені результати показників тривожного та депресивного синдрому в пацієнтів із ревматоїдним артритом через 3 місяці від початку курсу фізичної терапії / реабілітації показали зниження рівня тривоги та депресії за шкалою HADS в обстежених групах. Водночас у пацієнтів основної групи зміни були більш вираженими, ніж у пацієнтів контрольної групи, де вказані показники були значно вищими. Аналіз показників тривожного та депресивного синдрому за опитувальником HADS після 6 місяців проведених реабілітаційних заходів засвідчив значне їх покращення в обстежених пацієнтів основної групи. Так, відсутність симптомів тривоги спостерігалися значно в більшої кількості пацієнтів основної групи – 62,5 % осіб, із відсутніми симптомами депресії – 68,7 % пацієнтів; у контрольної групи таких випадків було набагато менше: із відсутніми симптомами тривоги – 41,3 % осіб, із відсутніми симптомами депресії – 53,3 % пацієнтів. Висновки. Ефективність розробленої технології реабілітаційних заходів підтверджується достовірним покращенням показників за шкалою HADS у пацієнтів основної групи, на відміну від показників контрольної групи, які були значно гіршими.
СТРАТЕГІЯ ЗАБЕЗПЕЧЕННЯ ПРОДОВОЛЬЧОЇ БЕЗПЕКИ УКРАЇНИ В УМОВАХ ВІЙНИ
Authors: Кривохижа Євген , Башлай Сергій , Курило Юрій
Published: November 2023

Стаття присвячена дослідженню та розробці стратегії забезпечення продовольчої безпеки в умовах війни. В сучасних умовах ця тема набуває особливої актуальності для України, оскільки вона стикається з різноманітними викликами та складнощами в контексті геополітичних конфліктів та нестабільності. Метою статті є вивчення підходів до розв'язання завдань забезпечення продовольчої безпеки в умовах військових дій та розробка оптимальної стратегії, що враховує військові обставини та забезпечує стале постачання продуктів харчування населенню. Дослідницький процес базувався на аналізі відповідних літературних джерел, документів та існуючих стратегій продовольчої безпеки. Основною новизною статті є розроблений стратегічний план продуктової безпеки на період післявоєнного відновлення. З урахуванням стратегічних напрямків, розроблених для забезпечення продовольчої безпеки в умовах післявоєнного відновлення, та ураховуючи складений стратегічний план на 2030 рік, важливо зазначити, що даний план відповідає поточній ситуації та враховує необхідність адаптації до викликів післявоєнного відновлення. Результати дослідження вказують на важливість врахування військової ситуації та особливостей післявоєнного відновлення при формуванні стратегії продовольчої безпеки. Перший етап передбачає відновлення інфраструктури та засобів виробництва, надання продовольчої допомоги та залучення інвестицій. Також підкреслюється важливість підготовки кваліфікованих фахівців та забезпечення безпеки сільськогосподарських угідь. Другий етап спрямований на зміцнення продовольчої безпеки та включає розробку систем реагування на кризові ситуації, заохочення інновацій у сільському господарстві, співпрацю з міжнародними партнерами, зміцнення ринків продовольчих товарів та охорону навколишнього середовища. Практичне значення дослідження полягає в можливості застосування розробленого стратегічного плану органами влади та громадськими організаціями для забезпечення сталого доступу населення до продуктів харчування в умовах конфлікту та війни.
FINANCIAL ASPECTS OF INNOVATIVE DEVELOPMENT
Authors: Заїка Світлана , Грідін Олександр , Заїка Олена
Published: November 2023

Innovation is a key factor in economic growth and competitiveness. It enables businesses to create new products and services, which increases their efficiency and profitability. However, innovation is costly. It requires significant financial resources, which are not always available to enterprises. This is one of the main problems hindering the innovative development of the economy. The purpose of this article is to study modern approaches to financing innovations, identify the factors that influence the choice of financing sources, identify existing problems, and develop proposals for their solution. The article examines the main sources of financing innovations, which include budget financing, company’s own funds, and attracted and borrowed funds. It argues that effective financing of innovative activity requires a comprehensive approach that takes into account both internal and external factors. Solving the problems of financing innovations and increasing the efficiency of innovative projects is an important task for increasing the competitiveness of the economy. For the successful development of innovations, it is necessary to create a favorable environment for financing and develop effective mechanisms for evaluating the effectiveness of innovative projects. Solving the problems identified during the research will help increase the level of innovative activity in the country and contribute to the growth of its competitiveness.
Las caras del prisma en la formación de investigadores
Authors:   Tecnológico Nacional de México/IT de Ciudad Jiménez, Chihuahua, México, Sánchez Luján Bertha Ivonne , Carrera Hernández Celia ,   Universidad Pedagógica Nacional del Estado de Chihuahua, Campus Chihuahua, México
Published: November 2023

La investigación educativa es el prisma a través del cual se ilumina el conocimiento en el ámbito de la educación, descomponiendo sus distintas facetas para comprender su complejidad y transformarla en saberes significativos. En este libro, titulado Las caras del prisma en la formación de investigadores, nos adentramos en un fascinante viaje por los diferentes enfoques, reflexiones y experiencias que dan forma a la formación de investigadores educativos. La necesidad de fortalecer la investigación educativa se vuelve más apremiante que nunca. La sociedad contemporánea enfrenta desafíos y cambios constantes, y la educación juega un papel crucial en la cons­trucción de un futuro más justo y equitativo. Para responder a estos desafíos es imprescindible formar a investigadores capaces de abordar problemáticas complejas y de generar soluciones innovadoras que im­pacten positivamente en la práctica docente y en las políticas educativas El texto tiene como objetivo aportar una visión integral y multidis­ciplinar sobre la formación de investigadores, que permita reflexionar sobre sus desafíos actuales y proponer estrategias y soluciones para mejorarla. En resumen, este libro es una valiosa herramienta para aquellos interesados en la formación de investigadores y la investigación educativa, en la que se aborda desde distintas perspectivas la importancia de la investigación educativa y se presentan experiencias y reflexiones que contribuyen al desarrollo de esta área de estudio.
KEBERKESANAN PENGGUNAAN MEDIUM PAPAN TANDA DALAM KEMPEN BAHAYA PENYALAHGUNAAN DADAH
Authors: Jamri Mohamad Hafifi , Ismail Nurzali , Ridzuan Abdul Rauf , Rosli Nurul Hafizah , Abdul Rani Nur Shazana , Ibrahim Noor Afzaliza Nazira , Hassan Hanita , Sultan Mohideen Rosilawati
Published: November 2023

Papan tanda merupakan sebuah media konvensional luar yang digunakan sebagai platform penyampaian informasi kepada masyarakat. Penggunaan papan tanda dalam aktiviti promosi dan kempen di negara ini dirujuk masih lagi berlangsung sehingga ke hari ini termasuklah dalam Kempen Bahaya Penyalahgunaan Dadah. Objektif kajian ini dijalankan adalah untuk menilai keberkesanan strategi lokasi media luar papan tanda dalam Kempen Bahaya Penyalahgunaan Dadah. Kaedah kajian keratan rentas kuantitatif survei digunakan bagi pengrekrutan sejumlah 400 orang belia di negeri Pulau Pinang. Dapatan kajian menunjukkan bahawa keberkesanan strategi lokasi media luar papan tanda dalam kempen adalah di tahap sederhana tinggi. Penambahbaikan strategi ini masih boleh dijalankan dalam usaha memastikan keberkesanannya dapat dipertingkatkan sekaligus menjadikan kempen lebih berimpak kepada golongan masyarakat.
Kültürlerarası Modeller Merceğinden Göç Yönetiminde Ebelik Hizmetleri
Authors: Hancıoğlu Aytaç Selma
Published: November 2023

Bir coğrafi yer değişimi olarak tanımlanan göç, dünya çapında artarak devam ederken özellikle zorunlu göç edenler için önemli sorunları da beraberinde getirmekte ve toplumun genelinde sosyal yaşamı, kültürel normları, ekonomik ve fizikî koşullarla birlikte göçmen sağlığına da olumsuz etki etmektedir.
Kadınlar, mülteci grubunun dezavantajlı gruplarındandır. Türkiye’de; Irak, Rusya Federasyonu, Türkmenistan, İran, Suriye, Azerbaycan, Özbekistan, Afganistan, Ukrayna, Kazakistan, Suriye vb. ülkelerden mülteci statüsünde gelenler arasında Suriye’den gelenlerin çoğunluğu oluşturduğu görülmekte ve kalıcı nüfus oluşturan topluluğun neredeyse yarısının kadın olması dikkat çekmektedir. Bu da, politikalar belirlenirken üzerinde durulması gereken önemli bir konudur. Kadınların yaşam tarzı, sağlık inançları ve sağlık uygulamalarının dikkate alındığı bir yaklaşım; hem kadınlar hem sağlık profesyonelleri için pratikte stres ve çatışmayı azaltılabilir ve sağlık bakımında verimi artırabilir.
Doğurganlık dönemi; 15-49 yaş aralığı, kadınların en yüksek oranda hizmete ihtiyaç duydukları dönem olarak bilinmektedir. Bu dönemdeki kadınların aile planlaması, üreme ve kadın sağlığı ile ilgili sağlık hizmetlerine ulaşması ve alabilmesi önemlidir. Süreçte hizmet sunacak sağlık profesyonelleri arasında ebeler yer almalıdır.
Görev tanımları gereği ebeler, verecekleri kültürlerarası ebelik bakımı ile meslek temsilcisi sivil toplum kuruluşları ve diğer disiplinlerle ortak çalışma sonucu süreç yönetimine katkı sağlayabilir. Bu çalışma, göçmen kadın sağlığına genel bakışla birlikte göç sürecinden en çok etkilenen kadınlara destek sağlamada ve uyumunu kolaylaştırmada ebelerin, kültürlerarası yaklaşımla katkı sağlayabilecek diğer bir disiplin olduğunu göstermek amacı ile ele alınmıştır.
ANALISIS SENTIMEN DAN TOPIK PERBINCANGAN NETIZEN INDONESIA MENGENAI KEBIJAKAN VAKSIN COVID-19
Authors: Dzikrillah Akhmad Rizal , Dyvia Oliviani Dyvia Oliviani
Published: November 2023

Pemerintah Republik Indonesia dalam upaya menjalankan percepatan penanganan penyebaran Covid-19 di Indonesia memiliki rencana mengenai pelaksanaan vaksinasi covid-19 bagi Masyarakat Indonesia pada tahun 2020 akhir. Akan tetapi, masyarakat masih banyak yang merasa kebingungan terhadap keamanan, efek samping dan cara memperolehnya. Pengumpulan data respon dan opini masyarakat Indonesia terhadap kebijakan vaksin COVID-19 dilakukan dengan menggunakan teknik web scraping pada media sosial twitter dalam bentuk tweets. Kegiatan mengklasifikasikan tweets atau analisis sentimen pada penelitian ini dilakukan dengan metode lexicon-based atau berbasis kamus positif-negatif. Mengacu pada penelitian yang dilakukan sebelumnya, kegiatan mengelompokkan opini masyarakat di media sosial twitter dilakukan dengan menggunakan model Latent Dirichlet Allocation (LDA). Sentimen positif lebih besar dibandingkan dengan Sentimen negatif mengenai kebijakan vaksin Covid-19. Topik-topik yang mencuat dan populer pada perbincangan para pengguna social twitter adalah topik edukasi fungsi vaksin, harapan, serta kepercayaan masyarakat terhadap vaksinasi . Topik populer yang lain adalah pemberitahuan netizen mengenai kegiatan vaksinasi yang telah dia ikuti.
PENENTUAN PENERIMA BIBIT PERTANIAN DI KABUPATEN SELUMA DENGAN METODE WEIGTHED PRODUCT
Authors: Darnita Yulia , Toyib Rozali , Rumbiyiani Riri
Published: November 2023

Pemberian Bantuan Bibit merupakan hal yang sangat penting dikarenakan harus tepat sasaran dalam proses penyeleksiannya. Adapun kriteria penilaian yang digunakan yaitu, jenis tanaman, luas lahan, kapasitas produksi, jumlah anggota, Umur kelompok tani dan pemeriksaan proposal, pertimbangan keputusannya masih berdasarkan perkiraan dan verifikasi datanya belum tersistem makan waktu yang lama. Metode Weighted Product dalam pengambilan keputusan dilakukan dengan menghubungkan rating dari setiap astribut dengan cara perkalian kemudian setiap astribut dipangkatkan dengan bobot setiap astribut, didalm system ini yang menjadi kriteria adalah tangka laku, nilai rata-rata. Hasil pengujian Poktan yang memiliki nilai vector v lebih besar atau sama dengan 0.01613 dinyatakan Layak mendapatkan bantuan bibit tanaman  dan Metode Weighted Product dapat menghasilkan data daftar prioritas penerima bantuan bibit pertanian
A CONVERSATION ANALYTIC INVESTIGATION ON EXPERTISE DEMONSTRATION IN COMMUNITY PHARMACY INTERACTION
Authors: ULUTAŞ DENİZ Elif , BOZBIYIK Merve
Published: November 2023

Objective: In recent years, there have been incresing numbers of the studies based on pharmacist communication skills in community pharmacy. However, different expertise knowledge provision within community pharmacy interaction is an under-researched area. This article aims to investigate how the expertise demonstration is deployed in a community pharmacy interaction.
Material and Method: 30-hour audio and video recordings were collected in a community pharmacy in Türkiye, and analysed through data-driven and bottom-up research perspective of Conversation Analysis.
Result and Discussion: The findings of the study show that the pharmacist displayed his expertise knowledge within three different sequential organizations initiated by the patient, pharmacy staff and pharmacist through a wide range of interactional practices such as providing extended explanations and advices, referring to external authority, and using both professional and trade knowledge. This micro-analytic study in pharmacy interaction makes an important contribution to pharmacy services and education.
Early life-history patterns in Patagonian toothfish Dissostichus eleginoides from the Patagonian Shelf
Authors: Lee B , Skeljo F , Randhawa HS , Brownscombe W , Arkhipkin A
Published: November 2023

Many long-lived, deep-sea species of the higher latitudes possess protracted egg and larval phases leading to dispersal across large geographical areas. The timing of ontogenetic life-history shifts is vital for understanding dispersal potential, a key driver of spatial patterns and stock structure of Patagonian toothfish Dissostichus eleginoides on the Patagonian Shelf. The early life-history patterns from hatching until settlement into a demersal habitat remain elusive and largely unexplored. We applied a complementary approach using otolith microstructure and trace element analysis (by laser ablation-inductively coupled plasma mass spectrometry) to infer time-resolved elemental profiles that reflect the early ontogeny of age-0+ toothfish from key nursery areas on the Patagonian Shelf. Results revealed significant ontogenetic shifts across the early life history. Key biological benchmarks were identified, including (1) the hatch date distribution (predicted mean = 3 October ± 8.47 d); (2) a period of natal dispersal (0-50 d post hatch [dph]; 22 November); (3) entry of pelagic larvae onto the Patagonian shelf (50-100 dph; 1 January); (4) settlement into a demersal habitat (100-120 dph; 31 January); and (5) the start of a downslope ontogenetic migration along pathways to the continental slope (>120 dph). The results provide important considerations in terms of the complexity and protracted nature of early life-history stages in Patagonian toothfish as a complex process, informing future research objectives relating to the identification of the stock origin on the Patagonian Shelf.
Augmentation of analgesic effect of ibuprofen by alprazolam in experimental model of pain.
Authors: Doležal T , Kršiak M
Published: November 2023

The reports of analgesic effects of benzodiazepines are inconsistent. There is evidence of a hyperalgesic effect induced by activation of supraspinal GABAA receptors and an antinociceptive effect induced by activation of receptors located in the spinal cord (dorsal horns). The aim of the study was to discover whether the systemic administration of a benzodiazepine agent alprazolam increases the systemic analgesic efficacy of non-opioid analgesic ibuprofen. Experimental studies combining these agents have not yet been published. We used three experimental methods - writhing test (with acetic acid), tail-flick test and plantar test to assess analgesic action. The drugs were administered orally. Augmentation of the analgesic effect of ibuprofen by alprazolam was proved for the writhing test at a dose of 30 mg/kg of ibuprofen and alprazolam 1 mg/kg. The reaction time of the combination was significantly prolonged in comparison with ibuprofen alone. The results of the tail-flick test and plantar test were negative. The effect of ibuprofen was not enhanced by alprazolam in tests of acute thermal pain. Our results have demonstrated that the analgesic action of ibuprofen is only weakly enhanced by alprazolam.
Formulation of Nano-fertilizer and Phytochemical Screening of orange peel were utilized to enhance the growth of Vigna radiata
Authors: Iqbal Saba , Parveen Gulnaz , Ayub Ambreen , Gul Salma , Batool Tahira , Tara Nain , Sami Amtul , Khowaja Atiya Hussain
Published: November 2023

Nanotechnology has developed into one of the most valued fields of sciences in the current century owing to the introduction of revolutionary changes in several disciplines of sciences. A key product of nanotechnology, i.e., nanoparticles (NPs) are abundantly used in modern research due to their novel applications. Orange peel contains vital nutrients that can be recycled into valuable material used for different purposes. In this study, we synthesized nano fertilizer from orange peel and tested its potential for promoting the growth of Vigna radiata and reducing the population of root rot pathogens. Nano-fertilizer extract was subjected to physical and chemical analyses for characterization. Transmission electron microscopy indicated spherical nanoparticles with sizes ranging between 18.22nm and 61.05nm.  While the X-Ray diffraction analysis the peaks were observed at 2ɵ value of 19.830, 20.550, 21.240, 24.440, 27.330 and 29.770 which represented the similarity with urea slandered peak.  The Synthesized nano-fertilizers contained phenols, steroids, triterpenes and xanthoproteins. In a screen house experiment, the nano fertilizer extract was administered to the seeds of Vigna radiata. The research demonstrated that increasing the dose of orange peel extract enhanced germination percentage by positively influencing plant growth characteristics. Meanwhile, a high concentration of orange peel amendment successfully reduced the colonization and infection percentage of root rotting pathogens when compared to the positive and negative controls.
Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review
Authors: Tang Xiao , Li Li , You Gehang , Li Xinyi , Kang Jian
Published: November 2023

Wound healing is a dynamic and complex restorative process, and traditional dressings reduce their therapeutic effectiveness due to the accumulation of drugs in the cuticle. As a novel drug delivery system, microneedles (MNs) can overcome the defect and deliver drugs to the deeper layers of the skin. As the core of the microneedle system, loaded drugs exert a significant influence on the therapeutic efficacy of MNs. Metallic elements and herbal compounds have been widely used in wound treatment for their ability to accelerate the healing process. Metallic elements primarily serve as antimicrobial agents and facilitate the enhancement of cell proliferation. Whereas various herbal compounds act on different targets in the inflammatory, proliferative, and remodeling phases of wound healing. The interaction between the two drugs forms nanoparticles (NPs) and metal-organic frameworks (MOFs), reducing the toxicity of the metallic elements and increasing the therapeutic effect. This article summarizes recent trends in the development of MNs made of metallic elements and herbal compounds for wound healing, describes their advantages in wound treatment, and provides a reference for the development of future MNs.
Computational charisma—A brick by brick blueprint for building charismatic artificial intelligence
Authors: Schuller Björn W. , Amiriparian Shahin , Batliner Anton , Gebhard Alexander , Gerczuk Maurice , Karas Vincent , Kathan Alexander , Seizer Lennart , Löchner Johanna
Published: November 2023

Charisma is considered as one's ability to attract and potentially influence others. Clearly, there can be considerable interest from an artificial intelligence's (AI) perspective to provide it with such skill. Beyond, a plethora of use cases opens up for computational measurement of human charisma, such as for tutoring humans in the acquisition of charisma, mediating human-to-human conversation, or identifying charismatic individuals in big social data. While charisma is a subject of research in its own right, a number of models exist that base it on various “pillars,” that is, dimensions, often following the idea that charisma is given if someone could and would help others. Examples of such pillars, therefore, include influence (could help) and affability (would help) in scientific studies, or power (could help), presence, and warmth (both would help) as a popular concept. Modeling high levels in these dimensions, i. e., high influence and high affability, or high power, presence, and warmth for charismatic AI of the future, e. g., for humanoid robots or virtual agents, seems accomplishable. Beyond, also automatic measurement appears quite feasible with the recent advances in the related fields of Affective Computing and Social Signal Processing. Here, we therefore present a brick by brick blueprint for building machines that can appear charismatic, but also analyse the charisma of others. We first approach the topic very broadly and discuss how the foundation of charisma is defined from a psychological perspective. Throughout the manuscript, the building blocks (bricks) then become more specific and provide concrete groundwork for capturing charisma through artificial intelligence (AI). Following the introduction of the concept of charisma, we switch to charisma in spoken language as an exemplary modality that is essential for human-human and human-computer conversations. The computational perspective then deals with the recognition and generation of charismatic behavior by AI. This includes an overview of the state of play in the field and the aforementioned blueprint. We then list exemplary use cases of computational charismatic skills. The building blocks of application domains and ethics conclude the article.
Determinants of device success after transcatheter aortic valve replacement in patients with type-0 bicuspid aortic stenosis
Authors: Xiao Zhicheng , Yao Jing , Liu Xinmin , Yuan Fei , Yan Yunfeng , Luo Taiyang , Wang Moyang , Zhang Hongliang , Ren Faxin , Song Guangyuan
Published: November 2023

Background

Clinical evidence of transcatheter aortic valve replacement in patients with type-0 bicuspid aortic valve was relatively scarce.

Aims

Our goal was to explore determinants of device success after transcatheter aortic valve replacement in patients with type-0 bicuspid aortic valve morphology.

Methods

In this retrospective multicenter analysis, we included 59 patients with symptomatic severe aortic stenosis with type-0 bicuspid aortic valve morphology who underwent transcatheter aortic valve replacement. Type-0 bicuspid aortic valve was identified with multidetector computed tomography scans. The technical success rate was 89.8%, and the device success rate was 81.4%. Patients were divided into a device success group and a device failure group according to Valve Academic Research Consortium- 3 criteria.

Results

When we compared the two groups, we found that the ellipticity index of the aortic root and the presence of bulky calcifications at the commissure were statistically different (ellipticity index 35.7 ± 1.7 vs. 29.7 ± 1.1, p = 0.018; bulky calcification at the commissure, 54.5% vs. 4.5%, p < 0.001). Further multivariate logistic analysis showed that bulky calcification at the commissure had a negative correlation with device success (odds ratio 0.030, 95% confidence interval 0.003–0.285, p = 0.002). Yet there was no statistical correlation between the ellipticity index and device success (odds ratio 0.818, 95% confidence interval 0.667–1.003, p = 0.053).

Conclusions

The presence of bulky calcifications at the commissure is negatively correlated with device success after transcatheter aortic valve replacement in patients with type-0 bicuspid aortic valve.
Long-term effects of 12-month integrated weight-loss programme for children with excess body weight- who benefits most?
Authors: Szczyrska Joanna , Brzeziński Michał , Szlagatys-Sidorkiewicz Agnieszka
Published: November 2023

The aim of the study was to assess long-term effects of the 12-month integrated weight-loss programme in children with excess body weight. We also attempted to identify the determinants of intervention effectiveness. Two groups were included in the analysis: 241 children with excess body weight who participated in the full 12-month intervention (full participation group) and 891 children with excess body weight who did not participate in the intervention (no participation group). Changes in BMI SDS, SBP SDS, DBP SDS and post-exercise HR with a follow-up period of 4 years between this groups were compared. In the full participation group, the reduction in mean BMI SDS was greater, we also observed significantly higher decrease in DBP SDS. Subgroup analysis by age category and sex showed a significant difference in the change in mean BMI SDS (from baseline to follow-up) in the subgroup of younger children and in the subgroup of younger girls. In the subgroup of younger girls significantly higher decrease in DBP SDS and SBP was also observed. Younger children, who participated in the intervention at age 6, particularly girls, benefited the most.
Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study
Authors: Zeng Qiaoli , Yang Taili , Wei Wenfeng , Zou Dehua , Wei Yue , Han Fengqiong , He Jieyun , Huang Jinzhi , Guo Runmin
Published: November 2023

Background

Glyoxalase 1 (GLO1) plays a crucial role in defending against glycation. Single nucleotide polymorphism (SNP) variants in the GLO1 gene may affect gene expression and alter enzyme activity. However, there have been limited studies evaluating the association between GLO1 and diabetes, especially gestational diabetes mellitus (GDM). Therefore, this study is the first to explore the association of GLO1 SNPs and GDM risk.

Methods

The study included a total of 500 GDM patients and 502 control subjects. The SNPscan™ genotyping assay was used to genotype rs1781735, rs4746 and rs1130534. To assess the disparities in genotype, allele, and haplotype distributions and their correlation with GDM risk, the independent sample t-test, logistic regression, and chi-square test were employed during the data processing phase. Furthermore, one-way ANOVA was conducted to determine the differences in genotype and blood glucose and methylglyoxal(MG) levels.

Results

Significant differences were observed in prepregnancy body mass index (pre-BMI), age, systolic blood pressure (SBP), diastolic blood pressure (DBP), and parity between GDM and healthy subjects (P < 0.05). After adjusting for these factors, GLO1 rs1130534 TA remained associated with an increased risk of GDM (TA vs. TT + AA: OR = 1.320; 95% CI: 1.008-1.728; P = 0.044), especially in the pre-BMI ≥ 24 subgroup (TA vs. TT + AA: OR = 2.424; 95% CI: 1.048-5.607; P = 0.039), with fasting glucose levels being significantly elevated in the TA genotype compared to the TT genotype (P < 0.05). Conversely, the GLO1 rs4746 TG was associated with a decreased risk of GDM (TG vs. TT: OR = 0.740; 95% CI: 0.548-0.999; P = 0.049; TG vs. TT + GG: OR = 0.740; 95% CI: 0.548-0.998; P = 0.048). Additionally, the haplotype T-G-T of rs1781735, rs4746 and rs1130534 was associated with a decreased risk of GDM among individuals with a pre-BMI ≥ 24 (OR = 0.423; 95% CI: 0.188-0.955; P = 0.038). Furthermore, the rs1781735 GG genotype was found to be more closely related to maternal MG accumulation and neonatal weight gain (P < 0.05).

Conclusion

Our findings suggested that GLO1 rs1130534 was associated with an increased susceptibility to GDM and higher blood glucose levels, but GLO1 rs4746 was associated with a decreased risk of GDM. The rs1781735 has been associated with the accumulation of maternal MG and subsequent weight gain in neonates.
Childhood adversity predicts stronger premenstrual mood worsening, stress appraisal and cortisol decrease in women with Premenstrual Dysphoric Disorder
Authors: Nayman Sibel , Schricker Isabelle Florence , Reinhard Iris , Kuehner Christine
Published: November 2023

Background

Lifetime traumatic events are prevalent in women with Premenstrual Dysphoric Disorder (PMDD) and predict stronger premenstrual symptom intensities. Less is known about the unique effects of childhood adversity on PMDD. This study aims to investigate the menstrual cycle related course of mood, stress appraisal and cortisol activity over time and the effects of childhood adversity – by controlling for recent stressful life events – on the cyclicity of these outcomes.

Methods

Fifty-two women with PMDD completed questionnaires on childhood adversity and stressful life events during the past 12 months. Momentary negative and positive affect, stress appraisal, and saliva-cortisol were assessed within an Ambulatory Assessment (AA) design over four consecutive days during both the follicular and the late luteal phase. This AA was repeated after five months, resulting in two measurement bursts.

Results

Women with PMDD showed expected cycle related variations in mood and stress appraisal, whereby these effects weakened over time. No cortisol cyclicity was identified. Higher childhood adversity was linked to stronger increases in negative affect and stress appraisal, and stronger decreases in positive affect from the follicular toward the late luteal phase. Women with higher childhood adversity exhibited lower cortisol levels during the late luteal phase compared to the follicular phase whereas no such cyclicity was found in women with lower childhood adversity.

Conclusion

Childhood adversity appears to show independent deteriorating effects on premenstrual mood worsening and stress appraisal in women with PMDD. The observed cortisol cyclicity in women with higher childhood adversity may point to different neuroendocrine subtypes of PMDD in relation to childhood trauma and requires further systematic research.
Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study
Authors: Xie Weidong , Jiang Haojie , Chen Yao , Zhang Huanhao , Song Yaoyu , Yu Zhaojie , Gu Huayan , Xu Hongkai , Han Saiyi , Li Sen , Liu Naxin , Han Shaoliang
Published: November 2023

Background

Previous studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship between them is still unclear. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis using publicly available summary statistics data to evaluate whether there was a causal relationship between the two diseases.

Methods

Summary statistics for SLE and IBD were downloaded from the Open Genome-Wide Association Study and the International Inflammatory Bowel Disease Genetics Consortium. European and East Asian populations were included in this MR work. We adopted a series of methods to select instrumental variables that are closely related to SLE and IBD. To make the conclusion more reliable, we applied a variety of different analysis methods, among which the inverse variance–weighted (IVW) method was the main method. In addition, heterogeneity, pleiotropy, and sensitivity were assessed to make the conclusions more convincing.

Results

In the European population, a negative causal relationship was observed between SLE and overall IBD (OR = 0.94; 95% CI = 0.90, 0.98; P < 0.004) and ulcerative colitis (UC) (OR = 0.93; 95% CI = 0.88, 0.98; P = 0.006). After removing outliers with Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), the results remained consistent with IVW. However, there was no causal relationship between SLE and Crohn’s disease. In the East Asian population, no causal relationship was found between SLE and IBD.

Conclusion

Our results found that genetic susceptibility to SLE was associated with lower overall IBD risk and UC risk in European populations. In contrast, no association between SLE and IBD was found in East Asian populations. This work might enrich the previous research results, and it may provide some references for research in the future.
Gasdermins in sepsis
Authors: Wang Wenhua , He Zhihui
Published: November 2023

Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages. Gasdermins (GSDMs) proteins are pore-forming executors in the membrane, subsequently mediating the release of pro-inflammatory mediators and inflammatory cell death. With the increasing research on GSDMs proteins and sepsis, it is believed that GSDMs protein are one of the most promising therapeutic targets in sepsis in the future. A more comprehensive and in-depth understanding of the functions of GSDMs proteins in sepsis is important to alleviate the multi-organ dysfunction and reduce sepsis-induced mortality. In this review, we focus on the function of GSDMs proteins, the molecular mechanism of GSDMs involved in sepsis, and the regulatory mechanism of GSDMs-mediated signaling pathways, aiming to provide novel ideas and therapeutic strategies for the diagnosis and treatment of sepsis.
Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application
Authors: Li Yijin , Chen Renyu , Wang Chaofan , Deng Jun , Luo Shanshan
Published: November 2023

It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases. Hemopexin (HPX), a heme-binding protein with the highest affinity for heme in plasma, serves as an effective antagonist against heme toxicity resulting from severe acute or chronic hemolysis. In the present study, changes in HPX concentration were characterized at different stages of hemolytic diseases, underscoring its potential as a biomarker for assessing disease progression and prognosis. In many heme overload-driven conditions, such as sickle cell disease, transfusion-induced hemolysis, and sepsis, endogenous HPX levels are often insufficient to provide protection. Consequently, there is growing interest in developing HPX therapeutics to mitigate toxic heme exposure. Strategies include HPX supplementation when endogenous levels are depleted and enhancing HPX’s functionality through modifications, offering a potent defense against heme toxicity. It is worth noting that HPX may also exert deleterious effects under certain circumstances. This review aims to provide a comprehensive overview of HPX’s roles in the progression and prognosis of hematological diseases. It highlights HPX-based clinical therapies for different hematological disorders, discusses advancements in HPX production and modification technologies, and offers a theoretical basis for the clinical application of HPX.
Characterizing the weather band variability of the Texas shelf current
Authors: Nwankwo Uchenna C. , DiMarco Steven F. , Nowak Heather M. , Whilden Kerri , Buckingham Brian , Walpert John , Knap Anthony H.
Published: November 2023

Considering the benefits of understanding the circulation patterns of the shelf, it is not surprising that there are numerous studies of the Texas Shelf circulation patterns. Given that previous studies were focused on the low-frequency variability of the circulation which is upcoast (northeast flow) in the summer and downcoast (southwest flow) especially on the inner shelf in the non-summer seasons, this study investigates the weather band (2–15 days) variability of the Texas Shelf near-surface circulation pattern. Current meter data at 1.5 m below the sea surface from the inner, mid, and outer shelves were analyzed. This study demonstrated that there are high-frequency current reversals within the weather band in each season. From the estimated persistence of the currents during reversals, the inner and mid shelf currents are predominantly downcoast in the non-summer seasons and upcoast in the summer season whereas the outer shelf currents are mostly upcoast all year round. The Wavelets analysis of the currents revealed that most of the variabilities on the inner and mid shelf regions were within the 4-12-day band whereas on the outer shelf the dominant variability was within the 3–8-day band. From the cross-spectra analysis of both the currents and wind data, it was determined that the influence of the wind was more dominant on the inner and mid shelf regions at the 8–15-day band than on the outer shelf where the contribution of the wind is prevalent at the 2–4-day band.