bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy
Authors: Bustos Silvina Odete , Antunes Fernanda , Rangel Maria Cristina , Chammas Roger
Published: November 2020

The tumor microenvironment (TME) is a complex environment where cancer cells reside and interact with different types of cells, secreted factors, and the extracellular matrix. Additionally, TME is shaped by several processes, such as autophagy. Autophagy has emerged as a conserved intracellular degradation pathway for clearance of damaged organelles or aberrant proteins. With its central role, autophagy maintains the cellular homeostasis and orchestrates stress responses, playing opposite roles in tumorigenesis. During tumor development, autophagy also mediates autophagy-independent functions associated with several hallmarks of cancer, and therefore exerting several effects on tumor suppression and/or tumor promotion mechanisms. Beyond the concept of degradation, new different forms of autophagy have been described as modulators of cancer progression, such as secretory autophagy enabling intercellular communication in the TME by cargo release. In this context, the synthesis of senescence-associated secretory proteins by autophagy lead to a senescent phenotype. Besides disturbing tumor treatment responses, autophagy also participates in innate and adaptive immune signaling. Furthermore, recent studies have indicated intricate crosstalk between autophagy and the epithelial-mesenchymal transition (EMT), by which cancer cells obtain an invasive phenotype and metastatic potential. Thus, autophagy in the cancer context is far broader and complex than just a cell energy sensing mechanism. In this scenario, we will discuss the key roles of autophagy in the TME and surrounding cells, contributing to cancer development and progression/EMT. Finally, the potential intervention in autophagy processes as a strategy for cancer therapy will be addressed.
Promoting Breastfeeding and Interaction of Pediatric Associations With Providers of Nutritional Products
Authors: Bognar Zsolt , De Luca Daniele , Domellöf Magnus , Hadjipanayis Adamos , Haffner Dieter , Johnson Mark , Kolacek Sanja , Koletzko Berthold , Saenz de Pipaon Miguel , Shingadia Delane , Tissieres Pierre , Titomanlio Luigi , Topaloglu Rezan , Trück Johannes
Published: November 2020

Pediatric associations have been urged not to interact with and not to accept support from commercial providers of breast milk substitutes (BMSs), based on the assumption that such interaction would lead to diminished promotion and support of breastfeeding. The leadership of seven European pediatric learned societies reviewed the issue and share their position and policy conclusions here. We consider breastfeeding as the best way of infant feeding and strongly encourage its active promotion, protection, and support. We support the World Health Organization (WHO) Code of Marketing of BMSs. Infant formula and follow-on formula for older infants should not be advertised to families or the public, to avoid undermining breastfeeding. With consistently restricted marketing of BMSs, families need counseling on infant feeding choices by well-informed pediatricians. Current and trustworthy information is shared through congresses and other medical education directed and supervised by independent pediatric organizations or public bodies. Financial support from commercial organizations for congresses, educational, and scientific activities of pediatric organizations is an acceptable option if scientific, ethical, societal, and legal standards are followed; any influence of commercial organizations on the program is excluded, and transparency is ensured. Public–private research collaborations for improving and evaluating pharmaceuticals, vaccines, medical devices, dietetic products, and other products and services for children are actively encouraged, provided they are guided by the goal of enhancing child health and are performed following established high standards. We support increasing investment of public funding for research aiming at promoting child health, as well as for medical education.
Expression of Putative Defense Responses in Cannabis Primed by Pseudomonas and/or Bacillus Strains and Infected by Botrytis cinerea
Authors: Balthazar Carole , Cantin Gabrielle , Novinscak Amy , Joly David L. , Filion Martin
Published: November 2020

Cannabis (Cannabis sativa L.) offers many industrial, agricultural, and medicinal applications, but is commonly threatened by the gray mold disease caused by the fungus Botrytis cinerea. With few effective control measures currently available, the use of beneficial rhizobacteria represents a promising biocontrol avenue for cannabis. To counter disease development, plants rely on a complex network of inducible defense pathways, allowing them to respond locally and systemically to pathogens attacks. In this study, we present the first attempt to control gray mold in cannabis using beneficial rhizobacteria, and the first investigation of cannabis defense responses at the molecular level. Four promising Pseudomonas (LBUM223 and WCS417r) and Bacillus strains (LBUM279 and LBUM979) were applied as single or combined root treatments to cannabis seedlings, which were subsequently infected by B. cinerea. Symptoms were recorded and the expression of eight putative defense genes was monitored in leaves by reverse transcription quantitative polymerase chain reaction. The rhizobacteria did not significantly control gray mold and all infected leaves were necrotic after a week, regardless of the treatment. Similarly, no systemic activation of putative cannabis defense genes was reported, neither triggered by the pathogen nor by the rhizobacteria. However, this work identified five putative defense genes (ERF1, HEL, PAL, PR1, and PR2) that were strongly and sustainably induced locally at B. cinerea’s infection sites, as well as two stably expressed reference genes (TIP41 and APT1) in cannabis. These markers will be useful in future researches exploring cannabis defense pathways.
Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis
Authors: Wu Jinfeng , Yan Mingli , Zhang Dawei , Zhou Dinggang , Yamaguchi Nobutoshi , Ito Toshiro
Published: November 2020

Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression. However, the details of the ABA–BR crosstalk remain largely unknown. Here, we show that JUMONJI-C domain containing histone demethylases (JMJs) coordinate the antagonistic interaction between ABA and BR signaling pathways during the post-germination stage in Arabidopsis. BR blocks ABA-mediated seedling arrest through repression of JMJ30. JMJs remove the repressive histone marks from the BRASSINAZOLE RESISTANT1 (BZR1) locus for its activation to balance ABA and BR signaling pathways. JMJs and BZR1 co-regulate genes encoding three membrane proteins, a regulator of vacuole morphology, and two lipid-transfer proteins, each of which play a different role in transport. BZR1 also regulates stimuli-related target genes in a JMJ-independent pathway. Our findings suggest that the histone demethylases integrate ABA and BR signals, leading to changes in growth program after germination.
Grip Strength, Neurocognition, and Social Functioning in People WithType-2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia
Authors: Aliño-Dies María , Sánchez-Ortí Joan Vicent , Correa-Ghisays Patricia , Balanzá-Martínez Vicent , Vila-Francés Joan , Selva-Vera Gabriel , Correa-Estrada Paulina , Forés-Martos Jaume , San-Martín Valenzuela Constanza , Monfort-Pañego Manuel , Ayesa-Arriola Rosa , Ruiz-Veguilla Miguel , Crespo-Facorro Benedicto , Tabarés-Seisdedos Rafael
Published: November 2020

Background: Frailty is a common syndrome among older adults and patients with several comorbidities. Grip strength (GS) is a representative parameter of frailty because it is a valid indicator of current and long-term physical conditions in the general population and patients with severe mental illnesses (SMIs). Physical and cognitive capacities of people with SMIs are usually impaired; however, their relationship with frailty or social functioning have not been studied to date. The current study aimed to determine if GS is a valid predictor of changes in cognitive performance and social functioning in patients with type-2 diabetes mellitus and SMIs. Methods: Assessments of social functioning, cognitive performance, and GS (measured with an electronic dynamometer) were conducted in 30 outpatients with type 2 diabetes mellitus, 35 with major depressive disorder, 42 with bipolar disorder, 30 with schizophrenia, and 28 healthy controls, twice during 1-year, follow-up period. Descriptive analyses were conducted using a one-way analysis of variance for continuous variables and the chi-squared test for categorical variables. Differences between groups for the motor, cognitive, and social variables at T1 and T2 were assessed using a one-way analysis of covariance, with sex and age as co-variates (p < 0.01). To test the predictive capacity of GS at baseline to explain the variance in cognitive performance and social functioning at T2, a linear regression analysis was performed (p < 0.05). Results: Predictive relationships were found among GS when implicated with clinical, cognitive, and social variables. These relationships explained changes in cognitive performance after one year of follow-up; the variability percentage was 67.7%, in patients with type-2 diabetes mellitus and 89.1% in patients with schizophrenia. Baseline GS along with other variables, also predicted changes in social functioning in major depressive disorder, bipolar disorder, and schizophrenia, with variability percentages of 67.3, 36, and 59%, respectively. Conclusion: GS combined with other variables significantly predicted changes in cognitive performance and social functioning in people with SMIs or type-2 diabetes mellitus. Interventions aimed to improve the overall physical conditions of patients who have poor GS could be a therapeutic option that confers positive effects on cognitive performance and social functioning.
Development and Testing of a Novel Measure to Assess Fidelity of Implementation: Example of the Mini-AFTERc Intervention
Authors: Brandt Nathalie Georgia , McHale Calum Thomas , Humphris Gerald Michael
Published: November 2020

Background

Fidelity of implementation (FOI) reflects whether an intervention was implemented in clinical practice according to the originally developed manual and is a key aspect in understanding intervention effectiveness. To illustrate this process of developing a fidelity measure, this study uses the Mini-AFTERc, a brief psychological intervention aimed at managing breast cancer patients’ fear of cancer recurrence, as an example.

Objectives

To illustrate the development of an FOI measure through (1) applying this process to the Mini-AFTERc intervention, by including the design of a scoring system and rating criteria; (2) content validating the FOI measure using thematic framework analysis as a qualitative approach; (3) testing consistency of the FOI measure using interrater reliability.

Methods

The FOI measure was developed, its scoring system modified and the rating criteria defined. Thematic framework analysis was conducted to content validate the FOI measure using nine intervention discussions between four specialist cancer nurses and four breast cancer patients, and one simulated breast cancer patient. Intraclass-correlation was conducted to assess interrater reliability.

Results

The qualitative findings suggested that the Mini-AFTERc FOI measure has content validity as it was able to measure all five components of the Mini-AFTERc intervention. The interrater reliability suggested a moderate to excellent degree of reliability among three raters, rICC = 0.84, 95% CI [0.51, 0.96].

Conclusion

The study has illustrated the steps that an FOI measure can be developed through a systematic approach applied to the Mini-AFTERc intervention. The FOI measure was found to have content validity and was consistently applied, independently, by three researchers familiar with the Mini-AFTERc intervention. Future studies should determine whether similar levels of interrater reliability can be obtained by distributing written and/or video instructions to researchers who are unfamiliar with the FOI measure, using a larger sample. Employing developed and validated FOI measures such as the one presented for the Mini-AFTERc would facilitate implementation of interventions in the FCR field in clinical practice as intended.

Clinical Trial Registration

www.ClinicalTrials.gov, identifier: NCT03763825.
COVID-19 Related Distress Is Associated With Alcohol Problems, Social Media and Food Addiction Symptoms: Insights From the Italian Experience During the Lockdown
Authors: Panno Angelo , Carbone Giuseppe Alessio , Massullo Chiara , Farina Benedetto , Imperatori Claudio
Published: November 2020

Background: Several scholars hypothesize that one of the most negative impacts of the coronavirus disease 2019 (COVID-19) crisis would concern the increase of prevalence and severity of both substances and behavioral addiction. Despite the general concerns about the increase of prevalence and severity of addictions related to the COVID-19 emergency, few data are still available. Thus, the main aim of this study was to investigate the association between COVID-19 related distress and: (i) alcohol problems, (ii) social media addiction (SMA) symptoms, (iii) food addiction (FA) symptoms.

Methods: A national online-survey was carried out during the Italian lockdown (i.e., 9 March 2020–4 May 2020). In the current study, 1,519 participants (365 men and 1,154 women, mean age: 28.49 ± 10.89 years) were included. The survey included socio-demographic related items (e.g., age, sex, residential regions, education level, civil status, tobacco use, etc.), as well as ad-hoc developed questions aimed to investigate COVID-19 related variables (e.g., isolation/quarantine, personal diagnosis to COVID-19, friends or relatives with COVID-19 diagnosis, etc.). Participants also completed the following self-report measures in order to investigate: the psychological impact of COVID-19, alcohol problems, SMA symptoms, FA symptoms, and impulsivity.

Results: The psychological impact of COVID-19 was independently associated with alcohol problems (β = 0.058, p = 0.043), SMA symptoms (β = 0.259, p < 0.001), and FA symptoms (β = 0.150, p < 0.001).

Conclusion: Taken together, our results seem to confirm the general concerns about the negative impacts of the COVID-19 emergency on addictive behaviors, suggesting that this issue should be carefully monitored.
COVID-19 Solutions Are Climate Solutions: Lessons From Reusable Gowns
Authors: Baker Natalie , Bromley-Dulfano Rebecca , Chan Joshua , Gupta Anshal , Herman Luciana , Jain Navami , Taylor Anita Lowe , Lu Jonathan , Pannu Jaspreet , Patel Lisa , Prunicki Mary
Published: November 2020

The COVID-19 pandemic has laid bare the inadequacy of the U.S. healthcare system to deliver timely and resilient care. According to the American Hospital Association, the pandemic has created a $202 billion loss across the healthcare industry, forcing health care systems to lay off workers and making hospitals scramble to minimize supply chain costs. However, as the demand for personal protective equipment (PPE) grows, hospitals have sacrificed sustainable solutions for disposable options that, although convenient, will exacerbate supply strains, financial burden, and waste. We advocate for reusable gowns as a means to lower health care costs, address climate change, and improve resilience while preserving the safety of health care workers. Reusable gowns' polyester material provides comparable capacity to reduce microbial cross-transmission and liquid penetration. In addition, previous hospitals have reported a 50% cost reduction in gown expenditures after adopting reusable gowns; given the current 2000% price increase in isolation gowns during COVID-19, reusable gown use will build both healthcare resilience and security from price fluctuations. Finally, with the United States' medical waste stream worsening, reusable isolation gowns show promising reductions in energy and water use, solid waste, and carbon footprint. The gowns are shown to withstand laundering 75–100 times in contrast to the single-use disposable gown. The circumstances of the pandemic forewarn the need to shift our single-use PPE practices to standardized reusable applications. Ultimately, sustainable forms of protective equipment can help us prepare for future crises that challenge the resilience of the healthcare system.
Microbiology in the Field: Construction and Validation of a Portable Incubator for Real-Time Quantification of Coliforms and Other Bacteria
Authors: Wight Jordan , Varin Marie-Pierre , Robertson Gregory J. , Huot Yannick , Lang Andrew S.
Published: November 2020

Performing microbiological assays on environmental samples in field settings poses logistical challenges with respect to the availability of suitable equipment or the ability to get samples to the laboratory in a timely fashion. For example, the viability of some bacteria can decrease greatly between sampling and arrival to the laboratory for processing. We developed and constructed rugged, reliable, and cost-effective portable incubators that were used by 10 independent field teams to perform microbiological assays on surface water samples from lakes across Canada. Rigorous testing and validation of our incubators ensured that incubation conditions were consistent within and across all 10 field teams and 2 sampling years. Samples from all sites were processed in duplicate and bacterial counts were highly repeatable within and across sampling teams. Bacterial counts were also found to be statistically equivalent to counts obtained with standard laboratory techniques using a conventional incubator. Using this method, thermotolerant coliforms (TTCs) and Escherichia coli were quantified from 432 lakes, allowing comparison to both historical datasets that relied on TTCs and those following current guidelines that use E. coli counts. We found higher loads at the shoreline than the middle of lakes and different patterns between ecozones. E. coli was not frequently detected, but many lakes exceeded Canadian guideline values for activities such as swimming and some even exceeded the guideline value for secondary recreational activities such as boating. To the best of our knowledge, this is the largest bacteriological water quality assessment of freshwater lakes to date in terms of both spatial scale and the number of lakes sampled. Our incubator design can be easily adapted for a wide variety of researcher goals and represents a robust platform for field studies and other applications, including those in remote or low-resources settings.
Sensitivity and Tolerance of Different Annual Crops to Different Levels of Banana Shade and Dry Season Weather
Authors: Blomme Guy , Ntamwira Jules , Kearsley Elizabeth , Bahati Liliane , Amini Daniel , Safari Nancy , Ocimati Walter
Published: November 2020

Intercropping in small-holder production systems in East and Central Africa is very common and offers potential for significant yield and environmental benefits. However, the reduced light availability under banana canopies constrains the success of the intercrop in banana systems. Determining a balance between the optimal spacing/densities of banana plants with optimized intercrop selection based on their sensitivity and tolerance to shade is imperative. This study, through extensive field experiments performed in South Kivu, DR Congo investigated the resilience of a wide range of food and forage crops to varying banana shade levels. The same crop species grown as monocrops served as controls. Quantitative yield assessments showed yam, sweet potato, ginger and forage grasses to have a good potential to grow under moderately dense to dense banana fields. Taro, soybean, mucuna, chili, eggplant, and Crotalaria sp. performed well in sparsely spaced banana fields with moderate shading. Cassava and soybean showed limited tolerance to shade. Intercropping in banana systems is also generally confined to the rainy seasons due to the high sensitivity of most annual intercrops to long dry weather in the dry season months. We also thus assessed the sensitivity of chickpea and mucuna to the long dry weather of the dry seasons and found them to have great potential for extending farming production into the dry season. Overall, we show that careful selection and allocation of crops with varying sensitivity to various banana shade levels and dry season weather can potentially increase whole field productivity.
Oxidative and Epigenetic Changes and Gut Permeability Response in Early-Treated Chickens with Antibiotic or Probiotic
Authors: Ognik Katarzyna , Konieczka Paweł , Stępniowska Anna , Jankowski Jan
Published: November 2020

The aim of this study was to compare the effect of the use of enrofloxacin and a probiotic containing Enterococcus faecium and Bacillus amyloliquefaciens strains in the first week of life of chickens on oxidative and epigenetic changes in molecules and intestinal integrity. The three treatments were as follows: the control group received no additive in the drinking water (GC); the second group (GP) received a probiotic preparation in the drinking water during the first five days of life, providing E. faecium strain 4a1713 at 1.0 × 107 CFU/L water and B. amyloliquefaciens 4b1822 at 1.0 × 107 CFU/L water, the third group (GA) received an antibiotic (enrofloxacin 0.5 mL/L water) in the drinking water during the first five days of life. The use of both enrofloxacin and a probiotic containing E. faecium and B. amyloliquefaciens strains in chickens’ first week of life improved intestinal integrity and reduced inflammation and oxidative and epigenetic changes in the small intestine. This effect was evident both at 6 days of age and at the end of the rearing period.
Fasting Finisher Pigs before Slaughter Influences Pork Safety, Pork Quality and Animal Welfare
Authors: Driessen Bert , Freson Louis , Buyse Johan
Published: November 2020

The final phase in pork production is the transport of finisher pigs to the slaughterhouse. Fasting is one of the parameters that influence the stress coping ability of the pigs during transport and lairage. When implemented correctly with attention to the local factors, pre-slaughter fasting can improve animal welfare, pathogen risk and carcass hygiene. The length of pre-slaughter feed withdrawal time is important to the success of the production practice. In practice, a fasting time before slaughter between 12 and 18 h enhances pork safety, pork quality, and animal welfare. This means that communication between producer and slaughterhouse is essential when planning the fasting and lairage times to avoid carcass and technological pork quality problems (such as pale, soft, and exudative (PSE) meat or dark, firm and dry (DFD) meat).
Online Control Strategy for Plug-In Hybrid Electric Vehicles Based on an Improved Global Optimization Algorithm
Authors: Wang Shaoqian , Qin Datong
Published: November 2020

Neural networks are widely used in the learning of offline global optimization rules to reduce the fuel consumption and real-time performance of hybrid electric vehicles. Considering that the torque and transmission ratio are direct control variables, online recognition by a neural network of these two parameters is insufficiently accurate. In the meanwhile, the dynamic program (DP) algorithm requires huge computing costs. Based on these problems, a fusion algorithm combining a dynamic programming algorithm and an approximate equivalent fuel consumption minimum control strategy (A-ECMS) is proposed in this paper. Taking the equivalent factor as the control variable, the global optimal sequence of the factor is obtained offline. The back propagation (BP) neural network is used to extract the sequence to form an online control strategy. The simulation results illustrate that, compared with the traditional dynamic programming algorithm, although the fuel consumption increases slightly, the computational cost of the fusion algorithm proposed in this paper is significantly reduced. Moreover, because the optimal sequence of the equivalent factors is within a particular range, the online control strategy based on DP-A-ECMS has a high robustness. Compared with an online control strategy based on the torque and transmission ratio, the fuel economy is improved by 2.46%.
Sensor Micro and Nanoparticles for Microfluidic Application
Authors: Mazetyte-Stasinskiene Raminta , Köhler Johann Michael
Published: November 2020

Micro and nanoparticles are not only understood as components of materials but as small functional units too. Particles can be designed for the primary transduction of physical and chemical signals and, therefore, become a valuable component in sensing systems. Due to their small size, they are particularly interesting for sensing in microfluidic systems, in microarray arrangements and in miniaturized biotechnological systems and microreactors, in general. Here, an overview of the recent development in the preparation of micro and nanoparticles for sensing purposes in microfluidics and application of particles in various microfluidic devices is presented. The concept of sensor particles is particularly useful for combining a direct contact between cells, biomolecules and media with a contactless optical readout. In addition to the construction and synthesis of micro and nanoparticles with transducer functions, examples of chemical and biological applications are reported.
A Comprehensive Motivation of Multilayer Control Levels for Microgrids: Synchronization, Voltage and Frequency Restoration Perspective
Authors: Jackson Ronald , Zulkifli Shamsul Aizam , Benbouzid Mohamed , Salimin Suriana , Khan Mubashir Hayat , Elhassan Garba , Pathan Erum
Published: November 2020

The current paradigm in integrating intermittent renewable energy sources into microgrids presents various technical challenges in terms of reliable operation and control. This paper performs a comprehensive justification of microgrid trends in dominant control strategies. It covers multilayer hierarchical control schemes, which are able to integrate seamlessly with coordinated control strategies. A general overview of the hierarchical control family that includes primary, secondary, tertiary controls is presented. For power sharing accuracy and capability, droop and non-droop-based controllers are comprehensively studied to address further development. The voltage and frequency restoration techniques are discussed thoroughly based on centralized and decentralized method in order to highlights the differences for better comprehend. The comprehensive studies of grid synchronization strategies also overviewed and analyzed under balanced and unbalanced grid conditions. The details studies for each control level are displayed to highlight the benefits and shortcomings of each control method. A future prediction from the authors’ point of view is also provided to acknowledge which control is adequate to be adopted in proportion to their products applications and a possibility technique for self-synchronization is given in this paper.
Neuromorphic Spatiotemporal Information Processing Using Neuro-Photodetector Systems
Authors: Kumar Mohit , Kim Joondong
Published: November 2020

Spatiotemporal information processing within the human brain is done by a joint task of neurons and synapses with direct optical inputs. Therefore, to mimic this neurofunction using photonic devices could be an essential step to design future artificial visual recognition and memory storage systems. Herein, we proposed and developed a proof-of-principle two-terminal device that exhibits key features of neuron (integration, leaky, and relaxation) and synapse (short- and long-term memory) together in response with direct optical input stimuli. Importantly, these devices with processing and memory features, are further effectively integrated to build an artificial neural network, which are enabled to do neuromorphic spatiotemporal image sensing. Our approach provides a simple but effective route to implement for an artificial visual recognition system, which also has applications in edge computing and the internet of things.
Sport-Specific Differences in Power–Velocity–Force Profiling during Trunk Rotations at Different Loads
Authors: Zemková Erika , Poór Oliver , Jeleň Michal
Published: November 2020

This study investigates differences in power and velocity at different loads and power and force at different velocities during trunk rotations in athletes who practice sports with rotational demands on the trunk. Athletes of combat (n = 23), fighting (n = 39), ball (n = 52) and water sports (n = 19) with a mean age of 23.8 ± 1.5 years performed standing trunk rotations on each side with bars of different weights (from 1 kg up to 50 kg) placed on their shoulders. The findings showed significant between-group differences in mean power in the acceleration phase of trunk rotations, especially at higher weights (≥10.5 kg) or lower velocities (≤334.2 rad/s). The power at 10.5 kg was significantly higher in fighting than water (p = 0.035; d = 0.86), combat (p = 0.001; d = 1.53) and ball sports athletes (p = 0.001; d = 1.48), with no significant differences between the two latter groups; at 15.5 kg, it was higher in water than combat (p = 0.027; d = 0.91) and ball sports athletes (p = 0.009; d = 1.17) but not those in fighting sports; and at 20 kg, it was higher in water than combat (p = 0.013; d = 0.98) and ball sports athletes (p = 0.006; d = 1.33), with no significant differences with those in fighting sports. This testing is sensitive in discriminating between athletes of various sports, which may reflect the specificity of their training, including trunk rotations at various velocities under different load conditions.
A 5.43 nV/√Hz Chopper Operational Amplifier Using Lateral PNP Input Stage with BJT Current Mirror Base Current Cancellation
Authors: Kim Hyungseup , Kwon Yongsu , You Donggeun , Choi Hyun-Woong , Kim Seong Hyun , Heo Hyunwoo , Kim Choul-Young , Lee Hi-Deok , Ko Hyoungho
Published: November 2020

This paper presents a low-noise chopper operational amplifier using a lateral PNP input stage with bipolar junction transistor (BJT) current mirror base current cancellation. The BJT has a lower noise characteristic than the metal–oxide–semiconductor (MOS) transistor, where low-noise characteristics can be achieved by implanting the BJT to the input stage of the amplifier; however, the base current of the BJT input stage causes low input impedance of the amplifier. The BJT current mirror base current cancellation technique is implemented to enhance the input impedance of the BJT input stage by canceling the base current. BJT current mirror base current cancellation is implemented with a simple scheme using NPN transistors with deep n-well in a generic complementary metal–oxide–semiconductor (CMOS) process. For further noise reduction with the BJT input stage, a chopper amplifier scheme is adopted to reduce low-frequency components such as 1/f noise terms in the low-frequency range. The prototype chip is fabricated in a 0.18-μm CMOS process. The active area of the prototype amplifier is 0.213 mm2. The measured input-referred noise is 5.43 nV/√Hz. The measured input base current of the amplifier with base current cancellation is 67.971 nA. The total amplifier current consumption is 278.3 μA, with a power supply of 3.3 V.
Oblique Deposition of Ti/Pt/Au Electrode on Photonic Crystal for Vertical Current Injection
Authors: Ye Hanqiao , Saeki Ryota , Xiong Yifan , Kogure Takashi , Morifuji Masato , Kajii Hirotake , Maruta Akihiro , Kondow Masahiko
Published: November 2020

We describe a device for inter-chip or intra-chip optical communications that contains the Circular Defect in photonic crystal (CirD) lasers array driven by vertical current injection. In order to improve the conductivity of the structure while also preventing current leakage, we introduce the oblique deposition of electrodes on a photonic crystal pattern by using an electron beam evaporation apparatus. The performance of an electrode is investigated by a transmission line method, and the CirD structure is fabricated with the electrode. We analyze the voltage-current relationship and confirm the CirD structure’s low resistance of under 1 kΩ.
Impact of Preheating Temperatures and RAP Characteristics on the Activation of RAP Binder
Authors: Meng Yifu , Liu Liping
Published: November 2020

Reclaimed asphalt pavement (RAP) is preheated to 120 °C or lower in hot central plant recycling due to specification and equipment limitations. However, the insufficient activation of reclaimed asphalt (RA) caused by low preheating temperature may affect the final properties of reclaimed asphalt mixtures (RAM) and lead to insufficient utilization of RA binder. This study evaluated the influence of preheating temperature and aging of RA binder on binder activation by producing specimens with 100% RAP. The volumetric and mechanical properties of specimens were analyzed to reflect the effect of activation. The results indicate that preheating temperature has a significant impact on the activation of RA binder. Regardless of the source of RAP, RA binder can be highly activated at 180 °C, while the degree of activation decreases significantly at 120 °C. By using an artificial RAP with different degrees of aging, the aging of RA binder is found to be harmful to activation only when the preheating temperature is low (such as 120 °C). Hence, if the equipment is capable of doing so, it is better to raise the preheating temperature of RAP to improve the activation of RA binder, especially for binder with a higher degree of aging.
Study on Aided Optical Alignment by Programmable Spots Array Generated by Off-Axis Parabolic Phase Based on LCoS-SLM
Authors: Zeng Zhen , Li Zexiao , Fang Fengzhou , Zhang Xiaodong
Published: November 2020

We present an aided optical alignment method using the liquid crystal on silicon spatial light modulator (LCoS-SLM). An optical system composed of an interferometer and an LCoS-SLM was established to verify the effectiveness of the method. The system was also calibrated to solve the phase modulation nonlinear and nonuniformity problem for better performance of LCoS-SLM as an easily programmable phase compensator. The LCoS-SLM could modulate the phase of incident light precisely to generate an accurate phase desired to achieve a virtual off-axis parabolic phase to generate light spots array. Finally, the 2 × 2 light spots array generated by the optical system was used to verify its potential in optical alignment.
Sleep Quality in Older Women: Effects of a Vibration Training Program
Authors: Palop-Montoro María Victoria , Lozano-Aguilera Emilio , Arteaga-Checa Milagros , Serrano-Huete Víctor , Párraga-Montilla Juan Antonio , Manzano-Sánchez David
Published: November 2020

Background: Sleep is an important phenomenon to restore the body, both physically and emotionally, providing a state of balance in the person. It has been proven that adequate sleep at night is one of the main needs of older people in order to maintain an active and healthy life; among other factors, regular physical exercise can improve the quality of sleep. The aim of this research is to evaluate the effects of a physical exercise program supplemented with vibration training on sleep quality and the use of sleep drugs in women over 65 years of age. Methods: Fifty-two independent, physically active adult women were randomised into two groups: a physical exercise program (n = 26, control group) and the same physical exercise program supplemented with vibration training (n = 26, experimental group). The control group performed two weekly sessions of exercise, and the experimental group added another two sessions of vibration training to these two sessions for 12 weeks. Sleep quality was assessed using the Pittsburgh index. Statistical significance was established as p < 0.05. Results: After the intervention, there were significant changes to the quality of sleep (p = 0.001) and hours of sleep (p = 0.002) in the experimental group. The consumption of drugs decreased in this group, although not significantly; however, it did have a moderate effect size (p = 0.058; d = 0.36). The control group, on the other hand, reported significantly worsened sleep quality (p = 0.001) and increased drug use (p = 0.008). Conclusion: Three months of vibration training, as a complement to a conventional physical exercise program, improves sleep quality and reduces the consumption of sleeping pills in women over 65 years of age.
“Dance and Abstraction” Special Issue Introduction
Authors: Archias S. Elise , Bellow Juliet
Published: November 2020

In his 2013 book Hating Empire Properly, historian Sunil Agnani helpfully reminds his audience that an emphasis on cultural difference—a perspective that we tend to think of as the postmodern antidote to Enlightenment-era universalizing rhetoric—can in fact be traced back to early modern European thought [...]
The Evolution of a Consolidated Market for Neo-Traditional Chinese Contemporary Art
Authors: Robertson Iain
Published: November 2020

The purpose of this paper is to determine whether there is an incipient market in China strong enough to replace the global market for Chinese contemporary art. The (informal) market I have identified supports traditional methods of transaction and practice. It charts a course twixt slavish emulation of the past and unqualified acceptance of the present. To demonstrate the contemporary application of this trend, I introduce three case studies, which examine the attitude and behaviour of three Chinese artists active between 2005 and 2015. This period marks the transformation of China from an aspirant economic power to a self-confident advocate of Chinese values. The premise of this paper is that the China market today is moving towards a harmonious ideal rooted in Chinese thought. In the nineteenth-century art movement known as the Shanghai School, I have found a precedent for the evolutionary transformation of Chinese art from the traditional to the modern. This study will reveal how the Shanghai School market might be an exemplar for today’s Chinese contemporary art market. I will refer to this historical model to show how conventional methods of creation, distribution and consumption can effectively be modernised. Another effort to culturally transform China was attempted a generation later in the southern city of Guangzhou. The movement, known as the Lingnan School, attempted to fuse Western-style realism with Chinese techniques and media. I argue that these two early attempts to amalgamate the traditional with the modern failed to metamorphose into a consolidated Chinese contemporary art market model. They have, instead, resulted in the co-existence of two corrupted models; the one, a diffident fusion of the past and the modern world, and the other a concerted alliance of nationalism and globalism.
Microbiota and Obesity: Where Are We Now?
Authors: Ballini Andrea , Scacco Salvatore , Boccellino Mariarosaria , Santacroce Luigi , Arrigoni Roberto
Published: November 2020

Genetic and environmental factors are underlying causes of obesity and other metabolic diseases, so it is therefore difficult to find suitable and effective medical treatments. However, without a doubt, the gut microbiota—and also the bacteria present in the oral cavity—act as key factors in the development of these pathologies, yet the mechanisms have not been fully described. Certainly, a more detailed knowledge of the structure of the microbiota—composition, intra- and inter-species relationships, metabolic functions—could be of great help in counteracting the onset of obesity. Identifying key bacterial species will allow us to create a database of “healthy” bacteria, making it possible to manipulate the bacterial community according to metabolic and clinical needs. Targeting gut microbiota in clinical care as treatment for obesity and health-related complications—even just for weight loss has become a real possibility. In this topical review we provide an overview of the role of the microbiota on host energy homeostasis and obesity-related metabolic diseases, therefore addressing the therapeutic potential of novel and existing strategies (impact of nutrition/dietary modulation, and fecal microbiota transplantation) in the treatment of metabolic disease.
Mediators of Host–Microbe Circadian Rhythms in Immunity and Metabolism
Authors: Frazier Katya , Frith Mary , Harris Dylan , Leone Vanessa A.
Published: November 2020

Circadian rhythms are essential for nearly all life forms, mediated by a core molecular gene network that drives downstream molecular processes involved in immune function and metabolic regulation. These biological rhythms serve as the body’s metronome in response to the 24-h light:dark cycle and other timed stimuli. Disrupted circadian rhythms due to drastic lifestyle and environmental shifts appear to contribute to the pathogenesis of metabolic diseases, although the mechanisms remain elusive. Gut microbiota membership and function are also key mediators of metabolism and are highly sensitive to environmental perturbations. Recent evidence suggests rhythmicity of gut microbes is essential for host metabolic health. The key molecular mediators that transmit rhythmic signals between microbes and host metabolic networks remain unclear, but studies suggest the host immune system may serve as a conduit between these two systems, providing homeostatic signals to maintain overall metabolic health. Despite this knowledge, the precise mechanism and communication modalities that drive these rhythms remain unclear, especially in humans. Here, we review the current literature examining circadian dynamics of gut microbes, the immune system, and metabolism in the context of metabolic dysregulation and provide insights into gaps and challenges that remain.
Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions
Authors: Kudriaeva Anna A. , Saratov George A. , Kaminskaya Alena N. , Vladimirov Vasiliy I. , Barzilovich Petro Yu , Belogurov Alexey A.
Published: November 2020

Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a dose-dependent manner. Proteasome activity in the classical amine-containing buffers, such as 2-(N-morpholino)ethanesulfonic acid (MES), Tris, (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), glycylglycine, bis-Tris propane, and bicine, has a skewed distribution with a maximum at pH of 7.0–8.0. The activity of proteasomes in buffers containing imidazole and bis-Tris is maintained almost on the same level, in the pH range of 6.5–8.5. The third type of activation is observed in buffers based on the amino acids arginine and ornithine, as well as the natural polyamines spermine and spermidine. Proteasome activity in these buffers is dramatically increased at pH values greater than 7.5. Anionic buffers such as phosphate or carbonate, in contrast, inhibit proteasome activity during alkalization. Importantly, supplementation of a carbonate–phosphate buffer with spermine counteracts carbonate-driven proteasome stalling in alkaline conditions, predicting an additional physiological role of polyamines in maintaining the metabolism and survival of cancer cells.
Haptic Perception in Extreme Obesity: qEEG Study Focused on Predictive Coding and Body Schema
Authors: Gambino Giuditta , Giglia Giuseppe , Schiera Girolamo , Di Majo Danila , Epifanio Maria Stella , La Grutta Sabina , Lo Baido Rosa , Ferraro Giuseppe , Sardo Pierangelo
Published: November 2020

Haptic perception (HP) is a perceptual modality requiring manual exploration to elaborate the physical characteristics of external stimuli through multisensory integrative cortical pathways. Cortical areas exploit processes of predictive coding that collect sensorial inputs to build and update internal perceptual models. Modifications to the internal representation of the body have been associated with eating disorders. In the light of this, obese subjects were selected as a valid experimental model to explore predictive coding in haptic perception. To this purpose, we performed electroencephalographic (EEG) continuous recordings during a haptic task in normally weighted versus obese subjects. EEG power spectra were analyzed in different time intervals. The quality of haptic performance in the obese group was poorer than in control subjects, though exploration times were similar. Spectral analysis showed a significant decrease in theta, alpha and beta frequencies in the right temporo-parietal areas of obese group, whereas gamma bands significantly increased in the left frontal areas. These results suggest that severe obesity could be characterized by an impairment in haptic performances and an altered activation of multisensory integrative cortical areas. These are involved in functional coding of external stimuli, which could interfere with the ability to process a predicted condition.
Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naïve Patients with Resectable Non-Small-Cell Lung Cancer
Authors: Safi Seyer , Yamauchi Yoshikane , Hoffmann Hans , Weichert Wilko , Jost Philipp J. , Winter Hauke , Muley Thomas , Beckhove Philipp
Published: November 2020

Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines in the peripheral blood and tumor tissues from treatment-naïve patients with NSCLC (n = 36) and analyzed associations between local and systemic cytokine profiles and both TA-specific T cell responses and clinical parameters. We defined T cell responders as patients with circulating T cells that were reactive to TAs and T cell nonresponders as patients without detectable TA-specific T cells. TA-specific T cell responses were correlated with serum cytokine levels, particularly the levels of interleukin(IL)-4 and granulocyte colony-stimulating factor (G-CSF), but poorly correlated with the cytokine levels in tumor tissues. Nonresponders showed significantly higher serum IL-4 levels than responders (p = 0.03); the predicted probability of being a responder was higher for individuals with low serum IL-4 levels. In multivariable Cox regression analyses, in addition to IL-4 (hazard ratio (HR) 2.8 (95% confidence interval (CI): 0.78–9.9); p = 0.116), the age-adjusted IL-8 level (HR 3.9 (95% CI: 1.05–14.5); p = 0.042) predicted tumor recurrence. However, this study included data for many cytokines without adjustment for multiple testing; thus, the observed differences in IL-4 or IL-8 levels might be incidental findings. Therefore, additional studies are necessary to confirm these results.