bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Reinforcement Learning-Based Trading Strategy for Load Aggregators on Price-Responsive Demand
Authors: Yang Guang , Du Songhuai , Duan Qingling , Su Juan
Published: September 2022

With the development of the Internet of things and smart grid technologies, modern electricity markets seamlessly connect demand response to the spot market through price-responsive loads, in which the trading strategy of load aggregators plays a crucial role in profit capture. In this study, we propose a deep reinforcement learning-based strategy for purchasing and selling electricity based on real-time electricity prices and real-time demand data in the spot market, which maximizes the revenue of load aggregators. The deep deterministic policy gradient (DDPG) is applied through a bidirectional long- and short-term memory (BiLSTM) network to extract the market state features that are used to make trading decisions. The effectiveness of the method is validated using datasets from the New England electricity market and Australian electricity market by introducing a bidirectional LSTM structure into the actor-critic network structure to learn hidden states in partially observable Markov states through memory inference. Comparative experiments of the method show that the method can provide greater yield results.
Enzymatic Activities of Bok Choy (Brassica rapa subsp. Chinensis) Grown Soil with the Amendment of Sandwich Compost
Authors: Phooi Chooi Lin , Azman Elisa Azura , Ismail Roslan
Published: September 2022

Soil enzymes ensure our food security, yet they are vulnerable to abiotic stresses. Solving the global issues of food waste by amending the Sandwich compost can be a great solution to ensure food security. Food waste Sandwich compost substrate (as soil amendment) and leachate (as seed priming solution and liquid fertilizer) were used to grow Bok Choy for 4 growing cycles, where soil pH, cation exchangeable capacity, moisture content, aggregate stability, and enzyme activity were determined. The Sandwich compost substrate amendment increased soil pH close to neutral and CEC up to 1.5-fold. Anaerobic Sandwich compost substrate-amended soil reduced soil catalase activity. Still, it steadily increased during the growing cycle. The Sandwich compost substrate amendment soil sustained the aggregate stability for 4 growing cycles. On the flip side, aggregate stability without the Sandwich compost substrate amended soil declined from the growing cycle to the next growing cycle. All variables were positively correlated except catalase activity. Henceforward, Sandwich compost substrate is recommended to improve soil quality in the aspects of pH, CEC urease activity, and dehydrogenase activity.
Security Hardened and Privacy Preserved Android Malware Detection Using Fuzzy Hash of Reverse Engineered Source Code
Authors: Ali Hasnat , Batool Komal , Yousaf Muhammad , Islam Satti Muhammad , Naseer Salman , Zahid Saleem , Gardezi Akber Abid , Shafiq Muhammad , Choi Jin-Ghoo
Published: September 2022

The risk of malware has increased drastically in recent years due to advances in the IT industry but it also increased the need for malware analysis and prevention. Hackers inject malicious code using awful applications. In this research, a framework is proposed to identify malicious Android applications based on repacked malicious code. The sensitive features of android applications are extracted using source code. These extracted features are compared with existing malware signatures to identify repacked malicious android applications. Experiments are performed using 3490 android-based malware samples belonging to 21 different malware families. A threshold value for malware categorization is defined using fuzzy logic. If the fuzzy comparison match is greater than 40%, the application is malicious. Meanwhile, if the match is greater than 10% and less than 40%, the application is suspicious otherwise benign. Furthermore, the proposed framework presents around 74% of the repacked malware compared to other similar approaches.
Electroacupuncture Improves Intestinal Motility through Exosomal miR-34c-5p Targeting SCF/c-Kit Signaling Pathway in Slow Transit Constipation Model Rats
Authors: Kuang Hongjun , Zhang Chengshun , Zhang Wei , Cai Huzhi , Yang Layuan , Yuan Nan , Yuan Yangyang , Yang Yutao , Zuo Chuanyi , Zhong Feng
Published: September 2022

Background. The pathogenesis of slow transit constipation (STC) is associated with exosomal miR-34c-5p. Electroacupuncture (EA) improves gastrointestinal motility in gastrointestinal disorders, especially STC. Our study aimed to explore the mechanism by which EA improves intestinal motility by modulating the release of exosomes and the transmission of exosomal miR-34c-5p. Methods. Fifty rats were randomly divided into five groups. STC model rats were induced, and GW4869, the exosome release inhibitor, was used to inhibit the release of exosome. The serum exosomes were authenticated under a transmission electron microscope and nanoparticle tracking analysis. RT-qPCR detected the expression of miR-34c-5p in serum exosomes and colonic tissues. The fecal number in 24 hours, Bristol scores, and intestinal transit rates were used to assess intestinal motility. Subsequently, hematoxylin and eosin (H&E) staining was used to examine the colonic mucosal histology. Finally, the expression of stem cell factor (SCF) and receptor tyrosine kinase (c-Kit) protein was measured using immunohistochemistry staining. Results. We found that EA upregulated exosomal miR-34c-5p in serum and downregulated miR-34c-5p in colonic tissues (

P
<
0.01

). EA improved fecal numbers in 24 hours, Bristol scores, and intestinal transit rates in STC rats (

P
<
0.01

). EA recovered the colonic histological structure and enhanced the expression of SCF and c-Kit protein (

P
<
0.01

). The therapeutic effect of EA was attenuated after inhibiting the release of the exosome. Conclusion. Our results indicated that EA improves intestinal motility in STC rats by transporting of exosomal miR-34c-5p targeting the SCF/c-Kit signaling pathway.
The Expression of GPR30 in Iron‐Overloaded Atypical Ovarian Epithelium and Ectopic Endometrium Is Closely Correlated with Transferrin Receptor and Pi3K
Authors: Long Li , Duan Zhaoning
Published: September 2022

Background. The mechanism of atypical hyperplasia of the ovarian epithelium and ectopic endometrium caused by iron overload remains unclear. Accordingly, we investigated possible effects on the human ovarian ectopic endometrium and ovarian epithelium by producing a high‐iron environment with rat ovaries. Objective. Human ovarian ectopic endometrium with atypical hyperplasia was collected, and the correlation between transferrin receptor GPR30 and Pi3K protein expression was studied by immunohistochemistry staining. Twenty SPF Sprague–Dawley female rats were microinjected with iron into one side of the ovary once a month, and the other ovary was used as the control. After 10 months of microinjection, the iron histological analysis was examined by Prussian blue staining, and ovarian endometrium morphology was assessed by HE staining. Abnormal lesion changes were measured by Pi3K staining. Evaluation of GPR30 was performed using reverse transcription PCR (RT‐PCR) and western blotting, and the interrelationship between GPR30 and Pi3K was also assayed. Results. GPR30 was significantly increased and correlated with the transferrin receptor and Pi3K in atypical human ovarian ectopic endometrium. Iron overload was confirmed in the 20 microinjected ovary cortexes, epithelial hyperplasia was observed in 12 ovaries, and papillary atypical hyperplasia was noted in eight ovaries. The RNA and protein levels of GPR30 were significantly increased in atypical hyperplasia compared to hyperplasia tissue samples. A positive relationship between GPR30 and Pi3K was found (P = 0.001). Conclusion. The results suggest that persistent iron exposure may be a potential stimulus for ovarian endometriosis with atypical changes, and the abnormal increase in the new estrogen receptor GPR30 is closely related to this process.
An Exploratory Study on the Effects of Invisible Violence on Students’ Mental Health in Physical Education
Authors: Liang Duan , Xiangjing Ren
Published: September 2022

Invisible violence in school physical education can negatively affect students’ body and mind and is detrimental to students’ sports cognition, sports participation, and sound personality cultivation and shaping. We analyze the manifestation and causes of invisible violence in physical education and propose a path to eliminate it, so as to improve the quality of school physical education and promote students’ physical and mental health. In this study, 30 students were interviewed, relevant research data were collected, and coding and clustering were conducted using the rooting theory research method. The results of the study are as follows: Invisible violence in physical education is characterized by concealment, unconsciousness, and indirect harm. According to the 11 characteristics of invisible violence in physical education, invisible violence in physical education is classified as invisible behavioral violence, invisible verbal violence, and invisible discrimination violence. The root causes of invisible violence in physical education are physical education teachers’ lack of understanding of the value of physical education, misplaced transfer of bad emotions and teaching. The root causes of invisible violence in physical education are teachers’ lack of understanding of the value of physical education, misplaced emotions, and the wrong expression of teaching language. The three countermeasures to eliminate invisible violence in physical education are: reshaping physical education teachers’ professional beliefs, improving physical education teachers’ emotional self‐management ability, and strengthening physical education teachers’ oral expression ability.
Fine Particulate Matter Concentrations during Independence Day Fireworks Display in the Lower Rio Grande Valley Region, South Texas, USA
Authors: Mendez Esmeralda , Temby Owen , Wladyka Dawid , Sepielak Katarzyna , Raysoni Amit U.
Published: September 2022

Fireworks are typically discharged as a mark of celebration and joy in many societies spanning various cultures. In the United States of America, 4th July is celebrated as the Independence Day when the nation overthrew the British colonial yoke in 1776. While this day instills a sense of patriotism in every American’s heart, it is also a major PM2.5 air pollution concern. This study is first of its type in the Lower Rio Grande Valley (RGV) Region of South Texas, USA, that characterizes fine particulate matter pollution. Using a low-cost sensor (TSI BlueSky Air Quality Monitor), real-time PM2.5 measurements were assessed at eleven different locations in four different towns and cities of Lower RGV Region: Brownsville, Edinburg, Weslaco, and Port Isabel. Hourly PM2.5 concentrations from July 03–06, 2021 are presented in this research work. Intraurban PM2.5 spatial and temporal variations provide an insight on the general population’s exposure burden during the festive period. Results indicate an increase in fine particulate matter pollution across the region, but the levels do not exceed the U.S. National Ambient Air Quality Standards (NAAQS). Findings from this study would possibly help in the formulation of effective firework policies to minimize the pollution impact.
Accuracy and Safety of Robot‐Assisted versus Fluoroscopy‐Guided Posterior C1 Lateral Mass and C2 Pedicle Screw Internal Fixation for Atlantoaxial Dislocation: A Preliminary Study
Authors: Zhan Jiheng , Xu Wenke , Lin Jinhao , Luan Jiyao , Hou Yu , Wang Yufeng , Li Yongjin , Chen Bolai , Lin Dingkun , Chen Shudong
Published: September 2022

Objective. To compare the accuracy, efficiency, and safety of robotic assistance (RA) and conventional fluoroscopy guidance for the placement of C1 lateral mass and C2 pedicle screws in posterior atlantoaxial fusion. Methods. The data of patients who underwent posterior C1–C2 screw fixation (Goel‐Harm’s technique) in our hospital from August 2014 to March 2021 were retrospectively evaluated, including 14 cases under fluoroscopic guidance and 11 cases under RA. The hospital records, radiographic results, surgical data, and follow‐up records were reviewed. Accuracy of screw placement was assessed using the Gertzbein and Robbins scale, and clinical outcomes were evaluated by Japanese Orthopedic Association (JOA) score, visual analogue scale (VAS), modified MacNab criteria, and postoperative complications. Results. Baseline characteristics of both groups were similar. The mean estimated blood loss in the fluoroscopic guidance and RA groups was 205.7 ± 80.3 mL and 120.9 ± 31.9 mL, respectively (p = 0.03). The mean surgical duration was 34 min longer with RA compared to that performed with free‐hand (FH) method (p = 0.15). In addition, lower intraoperative radiation exposure was detected in the RA group (12.4 ± 1.4 mGy/screw) versus the FH (19.9 ± 2.1 mGy/screw) group (p = 0.01). The proportion of “clinically acceptable” screws (graded 0 and I) was higher in the RA group (93.2%) than that in the FH group (87.5%, p = 0.04). There was no significant difference in the increase of JOA score and decrease of VAS score between the two surgical procedures. Furthermore, there were no significant differences in overall clinical outcome between the two groups and no neurovascular complications associated with screw insertion. Conclusions. RA is a safe and potentially more accurate alternative to the conventional fluoroscopic‐guided FH technique for posterior atlantoaxial internal fixation.
Evaluation of the Clinical Efficacy of the Classic Prescription “Baihe Dihuang Decoction” Based on Meta-Analysis
Authors: Peng Lei , Zhang Xiao-Fei , Guo Dong-Yan , Zhai Bing-Tao , Liang Yu-Jie , Chen Zhi-Ze , Zou Jun-Bo , Shi Ya-Jun
Published: September 2022

Purpose. To explore the clinical application of Baihe Dihuang Decoction. To provide certain data support and theoretical basis for the clinical application of Baihe Dihuang Decoction in the future. Methods. With “Baihe Rehmannia Tang” as the search term, the search was carried out on CNKI, VIP, Wanfang, PubMed and other databases. The statistical analysis of Baihe Dihuang decoction for treating diseases was obtained. Meta-analysis of the data was performed using RevMan 5.3 software to analyze the main therapeutic indicators of the disease. Results. According to the 83 valid literature that can be found, it is shown that 17 are used for the treatment of depression, 14 are used for the treatment of menopausal syndrome, 24 are used for the treatment of insomnia, and 28 are used for the treatment of other diseases. Conclusion. In the treatment of depression, menopausal syndrome, and insomnia combined with Baihe Dihuang Decoction can have a better therapeutic effect and diminish the incidence of adverse reactions. It provides a theoretical basis for the study and experimental study of its active components.
Development of a Public Transport Accessibility Index for Older Commuters: A Time-Based Approach
Authors: Fatima Kaniz , Moridpour Sara , Saghapour Tayebeh
Published: September 2022

The development of a public transport accessibility index for older travellers using total travel time is not a subject of frequent discussion. This study proposes a public transport accessibility index (EPTAI) which considers older peoples’ travel time and the populations of the second-smallest statistical areas according to census data. EPTAI identifies the level of access of the elderly to public transport (train, tram, and bus) in an urban area. The time-based EPTAI includes different trip purposes, including shopping trips (trips to shopping centres), medical trips (travel to healthcare centres), education trips (travel to education centres), and recreation trips (e.g., restaurants, parks, and cafes). The developed index is validated using statistical validation methods, including Pearson’s chi-square, likelihood ratio, linear-by-linear association, Cramer’s V, contingency coefficient, and phi. In addition, the performance of the developed index is compared with household survey data and the public transport accessibility level (PTAL). The results indicate that older adults’ public transport access varies depending on travel time, population density, and travel destination. The proposed index can be used for future planning/expansion and modification of public transport networks in urban and regional areas to meet the travel demands of older travellers.
Targeting Macrophages with CAR T Cells Delays Solid Tumor Progression and Enhances Antitumor Immunity
Authors: Sánchez-Paulete Alfonso R. , Mateus-Tique Jaime , Mollaoglu Gurkan , Nielsen Sebastian R. , Marks Adam , Lakshmi Ashwitha , Khan Jalal A. , Wilk C. Matthias , Pia Luisanna , Baccarini Alessia , Merad Miriam , Brown Brian D.
Published: September 2022

Tumor-associated macrophages (TAM) are one of the most abundant cell types in many solid tumors and typically exert protumor effects. This has led to an interest in macrophage-depleting agents for cancer therapy, but approaches developed to date have had limited success in clinical trials. Here, we report the development of a strategy for TAM depletion in mouse solid tumor models using chimeric antigen receptor (CAR) T cells targeting the macrophage marker F4/80 (F4.CAR-T). F4.CAR-T cells effectively killed macrophages in vitro and in vivo without toxicity. When injected into mice bearing orthotopic lung tumors, F4.CAR-T cells infiltrated tumor lesions and delayed tumor growth comparably with PD-1 blockade, and significantly extended mouse survival. Antitumor effects were mediated by F4.CAR-T–produced IFNγ, which promoted upregulation of MHC molecules on cancer cells and tumor-infiltrating myeloid cells. Notably, F4.CAR-T promoted expansion of endogenous CD8 T cells specific for tumor-associated antigen and led to immune editing of highly antigenic tumor cell clones. Antitumor impact was also observed in mouse models of ovarian and pancreatic cancer. These studies provide proof of principle to support CAR T-cell targeting of TAMs as a means to enhance antitumor immunity.
Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis
Authors: Kane Laura E. , Mellotte Gregory S. , Mylod Eimear , O'Brien Rebecca M. , O'Connell Fiona , Buckley Croí E. , Arlow Jennifer , Nguyen Khanh , Mockler David , Meade Aidan D. , Ryan Barbara M. , Maher Stephen G.
Published: September 2022

Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate below 5%. Carbohydrate antigen 19-9 (CA19-9) is the most commonly used blood-based biomarker for PDAC in current clinical practice, despite having been shown repeatedly to be inaccurate and have poor diagnostic performance. This review aims to assess the reported diagnostic accuracy of all blood-based biomarkers investigated to date in PDAC, by directly comparing individual biomarkers and multi-biomarker panels, both containing CA19-9 and not (novel). A systematic review was conducted in accordance with PRISMA standards in July 2020. Individualized search strategies for three academic databases identified 5,885 studies between the years 1973 and 2020. After two rounds of screening, 250 studies were included. Data were extracted and assessed for bias. A multivariate three-level meta-analysis with subgroup moderators was run in R using AUC values as effect size. On the basis of this model, the pooled AUC value for all multi-biomarker panels (AUC = 0.898; 95% confidence interval (CI): 0.88–0.91) was significantly higher than all single biomarkers (AUC = 0.803; 95% CI: 0.78–0.83; P < 0.0001). The pooled AUC value for CA19-9 alone was significantly lower compared with the multi-biomarker panels containing CA19-9 (P < 0.0001). For the novel biomarkers, the pooled AUC for single biomarkers was also significantly lower compared with multi-biomarker panels (P < 0.0001). Novel biomarkers that have been repeatedly examined across the literature, such as TIMP-1, CEA, and CA125, are highlighted as promising. These results suggest that CA19-9 may be best used as an addition to a panel of biomarkers rather than alone, and that multi-biomarker panels generate the most robust results in blood-based PDAC diagnosis.

Significance:

In a systematic review and three-level multivariate meta-analysis, it is shown for the first time that blood-based multi-biomarker panels for the diagnosis of PDAC exhibit superior performance in comparison with single biomarkers. CA19-9 is demonstrated to have limited utility alone, and to perform poorly in patient control cohorts of both healthy and benign individuals. Multi-biomarker panels containing CA19-9 produce the best diagnostic performance overall.
Usable Data Visualization for Digital Biomarkers: An Analysis of Usability, Data Sharing, and Clinician Contact
Authors: Scheuer Luke , Torous John
Published: September 2022

Background: While digital phenotyping smartphone apps can collect vast amounts of information on participants, less is known about how these data can be shared back. Data visualization is critical to ensuring applications of digital signals and biomarkers are more informed, ethical, and impactful. But little is known about how sharing of these data, especially at different levels from raw data through proposed biomarkers, impacts patients’ perceptions. Methods: We compared five different graphs generated from data created by the open source mindLAMP app that reflected different ways to share data, from raw data through digital biomarkers and correlation matrices. All graphs were shown to 28 participants, and the graphs’ usability was measured via the System Usability Scale (SUS). Additionally, participants were asked about their comfort sharing different kinds of data, administered the Digital Working Alliance Inventory (D-WAI), and asked if they would want to use these visualizations with care providers. Results: Of the five graphs shown to participants, the graph visualizing change in survey responses over the course of a week received the highest usability score, with the graph showing multiple metrics changing over a week receiving the lowest usability score. Participants were significantly more likely to be willing to share Global Positioning System data after viewing the graphs, and 25 of 28 participants agreed that they would like to use these graphs to communicate with their clinician. Discussion/Conclusions: Data visualizations can help participants and patients understand digital biomarkers and increase trust in how they are created. As digital biomarkers become more complex, simple visualizations may fail to capture their multiple dimensions, and new interactive data visualizations may be necessary to help realize their full value.
Carotid Artery Stenosis and Progression of Hemispheric Brain Atrophy: The SMART-MR Study
Authors: Ghaznawi Rashid , Rissanen Ina , de Bresser Jeroen , Kuijf Hugo J. , Zuithoff Nicolaas P.A. , Hendrikse Jeroen , Geerlings Mirjam I. ,   on behalf of the UCC-SMART-Study Group
Published: September 2022

Introduction: It has been hypothesized that carotid artery stenosis (CAS) may lead to greater atrophy of subserved brain regions; however, prospective studies on the impact of CAS on progression of hemispheric brain atrophy are lacking. We examined the association between CAS and progression of hemispheric brain atrophy. Methods: We included 654 patients (57 ± 9 years) of the SMART-MR study, a prospective cohort study of patients with manifest arterial disease. Patients had baseline CAS duplex measurements and a 1.5T brain MRI at baseline and after 4 years of follow-up. Mean change in hemispheric brain volumes (% of intracranial volume [ICV]) was estimated between baseline and follow-up for left-sided and right-sided CAS across three degrees of stenosis (mild [≤29%], moderate [30–69%], and severe [≥70%]), adjusting for demographics, cerebrovascular risk factors, and brain infarcts. Results: Mean decrease in left and right hemispheric brain volumes was 1.15% ICV and 0.82% ICV, respectively, over 4 years of follow-up. Severe right-sided CAS, compared to mild CAS, was associated with a greater decrease in volume of the left hemisphere (B = −0.49% ICV, 95% CI: −0.86 to −0.13) and more profoundly of the right hemisphere (B = −0.90% ICV, 95% CI: −1.27 to −0.54). This pattern was independent of cerebrovascular risk factors, brain infarcts, and white matter hyperintensities on MRI, and was also observed when accounting for the presence of severe bilateral CAS. Increasing degrees of left-sided CAS, however, was not associated with greater volume loss of the left or right hemisphere. Conclusions: Our data indicate that severe (≥70%) CAS could represent a risk factor for greater ipsilateral brain volume loss, independent of cerebrovascular risk factors, brain infarcts, or white matter hyperintensities on MRI. Further longitudinal studies in other cohorts are warranted to confirm this novel finding.
Diagnosis of Fluid Overload: From Conventional to Contemporary Concepts
Authors: Koratala Abhilash , Ronco Claudio , Kazory Amir
Published: September 2022

Fluid overload has been associated with morbidity and mortality in various clinical scenarios including heart failure and critical illness. It exerts pathologic sequelae in almost all the organ systems. Proper management of patients with fluid overload requires knowledge of the underlying pathophysiology, objective evaluation of volume status, selection of appropriate therapeutic options, and maintenance and modulation of tissue perfusion. There are several methods to appraise volume status but none without limitations. In this review, we discuss the diagnostic utility, prognostic significance, and shortcomings of various bedside tools in the detection of fluid overload and evaluation of hemodynamic status. These include clinical examination, biomarkers, blood volume assessment, bioimpedance analysis, point-of-care ultrasound, and remote pulmonary pressure monitoring. In our opinion, clinicians must adopt a multiparametric approach offsetting the limitations of individual methods to formulate a management plan tailored to patients’ needs.
O Museu Nacional além do Paço: três projetos no Horto Botânico da Quinta da Boa Vista
Authors: Correia Marina Pedroso
Published: September 2022

O Paço Imperial, edifício sede do Museu Nacional do Rio de Janeiro, sofreu, em 2 de setembro de 2018, um grande incêndio que devastou boa parte de seu interior, comprometendo não apenas seu acervo, mas também as dinâmicas da comunidade científica que ali cotidianamente se reunia. Três projetos desenvolvidos em uma ação emergencial coordenada por professores da Faculdade de Arquitetura e Urbanismo da Universidade Federal do Rio de Janeiro (FAUUFRJ) são apresentados com o intuito de revelar as espacialidades do Museu Nacional e suas funções acomodadas além do Paço Imperial, no Horto Botânico da Quinta da Boa Vista. Trata-se de intervenções em pequena escala e de sutil visibilidade que compõem, a partir das premissas do projeto arquitetônico, uma análise crítica das condições espaciais e dinâmicas funcionais que envolvem a história e o presente do Museu Nacional. Será apresentado, inicialmente, o ponto de partida teórico e prático das intervenções, marcado pelo debate acerca do potencial crítico do projeto arquitetônico e suas formas de representação. Em seguida, algumas temáticas metodológicas para o desenvolvimento do projeto arquitetônico no ambiente universitário serão abordadas com o intuito de fomentar a participação discente e docente nos processos de transformação, manutenção e expansão da infraestrutura universitária pública.
Educação museal e mediação do Núcleo de Ofiologia e Animais Peçonhentos da Bahia da Universidade Federal da Bahia
Authors: Lira-da-Silva Josefa Rosimere , Almeida Rosiléia Oliveira de , Lira-da-Silva Rejâne Maria
Published: September 2022

Os museus de ciências são espaços de educação e divulgação científica para diferentes públicos. Em 2017, o Instituto Brasileiro de Museus publicou a Política Nacional de Educação Museal (PNEM) e, em 2018, o Caderno da Política Nacional de Educação Museal. Nesse documento estão os princípios que regem o trabalho educativo museal. O objetivo deste trabalho foi investigar a mediação na divulgação científica sobre animais peçonhentos no Museu do Núcleo de Ofiologia e Animais Peçonhentos da Bahia (NOAP) com base na educação museal proposta pela PNEM. A mediação analisada foi de uma das exposições do NOAP, a Rede de Zoologia Interativa, que possui kits zoológicos, terrários com animais vivos e jogos sobre zoologia e desenvolve palestras e teatro de fantoches. Foram aplicados questionários ao público visitante da exposição e realizadas entrevistas individuais e grupo focal, com os mediadores da exposição, sobre a itinerância do museu, o contato com o público, a qualificação dos mediadores e a produção de material. Foi possível concluir que o NOAP tem um caminho que, em parte, atende às perspectivas do PNEM, principalmente em relação às discussões dos grupos de trabalho sobre estudos e pesquisa, acessibilidade e relação com a comunidade, no entanto, em relação à formação, qualificação e capacitação, o museu precisa aproximar sua dinâmica do que preconiza o documento, ainda que se ressalte que o PNEM é uma referência, e as instituições museais têm autonomia na sua gestão, tendo em vista suas especificidades.
O Museu de Arte da UFC, por entre reinvenções e ressignificações: notas em tempos pandêmicos
Authors: Siqueira Graciele Karine , Rocha Saulo Moreno , Correia Helem Cristina Ribeiro de Oliveira , Silveira Kathleen Raelle De Paiva
Published: September 2022

Este artigo tem por objetivo apresentar as ações e projetos desenvolvidos pelo Museu de Arte da Universidade Federal do Ceará (Mauc/UFC) durante o isolamento social em virtude da pandemia de covid-19. Durante este período, a equipe do museu passou a desenvolver seus trabalhos de maneira remota, buscando estratégias de atendimento ao público, de produção de conteúdo para o ambiente digital e de qualificação profissional por meio da participação em cursos e do estabelecimento de parcerias intra e interinstitucionais. As ações ensejaram novas modalidades de presentificação e articulação junto à sociedade, fortalecendo vínculos anteriores e deflagrando novos, favorecendo diálogos, intercâmbios e novas formas de ser museu. A metodologia consistiu na consulta aos documentos institucionais elaborados pela equipe na execução dos trabalhos durante este período, assim como outros documentos basilares sobre a história e a gestão do museu. A partir destas fontes, foram estruturadas a apresentação da história da instituição e de suas políticas de gestão e atuação antes e durante a pandemia de covid-19. Como resultado, este trabalho apresenta um relato multifacetado sobre políticas de gestão e atuação museal em tempos de crise, refletindo sobre os desafios e as experiências de um museu universitário na pandemia, com o objetivo de contribuir com as reflexões mais amplas sobre o campo museal, seus dilemas no contemporâneo e o papel da arte, da cultura e da ciência em tempos pandêmicos.
Acervos e coleções da Universidade Federal de Pelotas: identificar, conhecer e divulgar como política de preservação do patrimônio universitário
Authors: Bojanoski Silvana de Fátima , Bachettini Andréa Lacerda , Pereira Lisiane Gastal
Published: September 2022

Este artigo aborda os museus e coleções existentes em várias unidades da Universidade Federal de Pelotas (UFPel), incluindo os museus universitários, as coleções e objetos dispersos existentes em várias unidades, assim como os projetos de extensão que trabalham com as questões museológicas, de memória e de patrimônio junto à comunidade. Dá-se ênfase às ações realizadas para identificar e dar visibilidade aos acervos, tanto os que já são reconhecidos pelos seus valores museológicos ou documentais como aqueles que não se enquadram plenamente na definição formal de museu. Considera-se que as coleções e acervos formados a partir das atividades realizadas nas instituições de ensino superior constituem um patrimônio universitário significativo, não somente pelo seu valor de memória, bem como por espelhar e potencializar a produção do conhecimento, tanto no âmbito da pesquisa como do ensino e da extensão. Ressalta-se a necessidade de dar maior visibilidade a estes acervos, inclusive para os gestores, buscando-se estabelecer uma política de preservação e de divulgação do patrimônio histórico, cultural e científico universitário.
Museus da Universidade Federal do Pará: ensino, pesquisa e extensão
Authors: Santos Manuela Soutello Mendes da Fonseca , Benchimol Alegria Celia , Rocha Luisa Maria Gomes de Mattos
Published: September 2022

No Brasil, os museus universitários surgiram a partir da incorporação de instituições existentes ou através da criação de museus interligados ao ambiente universitário. Estes espaços têm particularidades que os diferenciam dos demais museus, porém, sem excluir as definições adotadas em esfera maior. Na Universidade Federal do Pará (UFPA), existem cerca de 12 espaços que se mostram como museus ou coleções universitárias. Por este número significativo, o questionamento que norteia o trabalho é quais são as ações que estes locais promovem, considerando o ambiente universitário e a tríade universitária de ensino, pesquisa e extensão que rege as universidades brasileiras. O objetivo é apresentar quais ações os museus e coleções universitárias da UFPA desenvolvem. As informações foram coletadas a partir de documentos institucionais e dos sites dos institutos e do Portal da UFPA, com o propósito de observar como esses lugares são citados e de que maneira são retratados. Os resultados indicam que nem todas as áreas são citadas por seus institutos ou pela própria universidade, mesmo que desenvolvam atividades que contribuem para o ensino, pesquisa e extensão. Museus e coleções universitárias podem contribuir para a difusão científica, cultural e tecnológica, elevando a visibilidade da diversidade de coleções da instituição, no entanto, o reconhecimento desses locais é fundamental para a viabilização do seu desenvolvimento e para o crescimento da universidade.
Harmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections, and Recommendations
Authors: Whelton Paul K. , Carey Robert M. , Mancia Giuseppe , Kreutz Reinhold , Bundy Joshua D. , Williams Bryan
Published: September 2022

The 2017 American College of Cardiology/American Heart Association and 2018 European Society of Cardiology/European Society of Hypertension clinical practice guidelines for management of high blood pressure/hypertension are influential documents. Both guidelines are comprehensive, were developed using rigorous processes, and underwent extensive peer review. The most notable difference between the 2 guidelines is the blood pressure cut points recommended for the diagnosis of hypertension. There are also differences in the timing and intensity of treatment, with the American College of Cardiology/American Heart Association guideline recommending a somewhat more intensive approach. Overall, there is substantial concordance in the recommendations provided by the 2 guideline-writing committees, with greater congruity between them than their predecessors. Additional harmonization of future guidelines would help to underscore the commonality of their core recommendations and could serve to catalyze changes in practice that would lead to improved prevention, awareness, treatment, and control of hypertension, worldwide.
Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden
Authors: Rillig Andreas , Borof Katrin , Breithardt Günter , Camm A. John , Crijns Harry J.G.M. , Goette Andreas , Kuck Karl-Heinz , Metzner Andreas , Vardas Panos , Vettorazzi Eik , Wegscheider Karl , Zapf Antonia , Kirchhof Paulus
Published: September 2022

Background:

The randomized EAST-AFNET4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial–Atrial Fibrillation Network) demonstrated that early rhythm control (ERC) reduces adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. The effectiveness and safety of ERC in patients with multiple cardiovascular comorbidities is not known.

Methods:

These prespecified subanalyses of EAST-AFNET4 compared the effectiveness and safety of ERC with usual care (UC) stratified into patients with higher (CHA
2
DS
2
-VASc score ≥4) and lower comorbidity burden. Sensitivity analyses ignored sex (CHA
2
DS
2
-VA score).

Results:

EAST-AFNET4 randomized 1093 patients with CHA
2
DS
2
-VASc score ≥4 (74.8±6.8 years, 61% female) and 1696 with CHA
2
DS
2
-VASc score <4 (67.4±8.0 years, 37% female). ERC reduced the composite primary efficacy outcome of cardiovascular death, stroke, or hospitalization for worsening of heart failure or for acute coronary syndrome in patients with CHA
2
DS
2
-VASc score ≥4 (ERC, 127/549 patients with events; UC, 183/544 patients with events; hazard ratio [HR], 0.64 [0.51–0.81];
P
< 0.001) but not in patients with CHA
2
DS
2
-VASc score <4 (ERC, 122/846 patients with events; UC, 133/850 patients with events; HR, 0.93 [0.73–1.19];
P
=0.56,
P
interaction
=0.037). The primary safety outcome (death, stroke, or serious adverse events of rhythm control therapy) was not different between study groups in patients with CHA
2
DS
2
-VASc score ≥4 (ERC, 112/549 patients with events; UC, 132/544 patients with events; HR, 0.84 [0.65, 1.08];
P
=0.175), but occurred more often in patients with CHA
2
DS
2
-VASc scores <4 randomized to ERC (ERC, 119/846 patients with events; UC, 91/850 patients with events; HR, 1.39 [1.05–1.82];
P
=0.019,
P
interaction
=0.008). Life-threatening events or death were not different between groups (CHA
2
DS
2
-VASc score ≥4, ERC, 84/549 patients with event, UC, 96/544 patients with event; CHA
2
DS
2
-VASc scores <4, ERC, 75/846 patients with event, UC, 73/850 patients with event). When female sex was ignored for the creation of higher and lower risk groups (CHA
2
DS
2
-VA score), the
P
interaction
was not significant for the primary efficacy outcome (
P
=0.25), but remained significant (
P
=0.044) for the primary safety outcome.

Conclusions:

Patients with recently diagnosed atrial fibrillation and CHA
2
DS
2
-VASc score ≥4 should be considered for ERC to reduce cardiovascular outcomes, whereas those with fewer comorbidities may have less favorable outcomes with ERC.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01288352. URL:
https://www.clinicaltrialsregister.eu
; Unique identifier: 2010-021258-20. URL:
https://www.isrctn.com/
; Unique identifier: ISRCTN04708680.
The Australian Pentastirini (Hemiptera: Fulgoromorpha: Cixiidae)
Authors: LÖCKER BIRGIT , FLETCHER MURRAY J. , LARIVIÈRE MARIE-CLAUDE , GURR GEOFF M.
Published: September 2022

The Australian Pentastirini are revised taxonomically. The fauna comprises 56 species, 38 of which are new to science. Species are classified into seven genera: Cordoliarus gen. nov., Miclucha Emeljanov, Oliarus Stål, Oteana Hoch, Ozoliarus gen. nov., Pentastiridius Kirschbaum and Prosops Buckton. All species are described and illustrated and identification keys to genera and species are provided. New species described are: Cordoliarus mareebensis sp. nov., Miclucha australiensis sp. nov., Oliarus acanthopygophoris sp. nov., O. cochleatus sp. nov., O. cuberlii sp. nov., O. globosus sp. nov., O. gracilis sp. nov., O. hamatus sp. nov., O. hirsutus sp. nov., O. lawlerorum sp. nov., O. trispiralis sp. nov., Ozoliarus alces sp. nov., Oz. antennoides sp. nov., Oz. bullocki sp. nov., Oz. bumarangoides sp. nov., Oz. catherinae sp. nov., Oz. cuspidistylus sp. nov., Oz. cynosurus sp. nov., Oz. dedariensis sp. nov., Oz. golgolensis sp. nov., Oz. latifundus sp. nov., Oz. maru sp. nov., Oz. nourlangiensis sp. nov., Oz. olene sp. nov., Oz. pelecanus sp. nov., Oz. pitta sp. nov., Oz. poculum sp. nov., Oz. quadratistylus sp. nov., Oz. quercistylus sp. nov., Oz. rotundistylus sp. nov., Oz. semicircularis sp. nov., Oz. serratus sp. nov., Oz. smithi sp. nov., Oz. taroomensis sp. nov., Oz. triangularis sp. nov., Oz. umbella sp. nov., Oteana salicoides sp. nov. and Ot. tattendi sp. nov. Lectotypes are designated for Oliarus clipealis Jacobi, Oliarus dingkana Distant, Oliarus felis Kirkaldy, Oliarus incerta Distant, Oliarus laertes Kirkaldy, Oliarus latipennis Jacobi, Oliarus lubra Kirkaldy, and Oliarus sponsa Kirkaldy. Oliarus latipennis Jacobi is synonymised with Pentastiridius felis (Kirkaldy) syn. nov., and Oliarus hackeri Muir and Miclucha morobensis (Van Stalle) are synonymised with Miclucha incerta (Distant) syn. nov. and Oliarus lubra var. vitiensis, Kirkaldy is synonymised with Oliarus lubra, Kirkaldy syn. nov. New combinations proposed are: Miclucha incerta (Distant) comb. nov., Oteana lubra (Kirkaldy) comb. nov., Oteana sponsa (Kirkaldy) comb. nov., Ozoliarus asaica (Kirkaldy) comb. nov., Ozoliarus clipealis (Jacobi) comb. nov., Ozoliarus dingkana (Distant) comb. nov., and Ozoliarus laertes (Kirkaldy) comb. nov., all from Oliarus. The following names are treated as nomina dubia since the only available types are females: Oliarus alexanor Kirkaldy, O. doddi Muir, O. kampaspe Kirkaldy, O. lilinoe Kirkaldy, O. phelia Kirkaldy, O. talunia Kirkaldy, Ozoliarus asaica (Kirkaldy), and Prosops pedisequus Buckton.
Taxonomic revision of the Odontophrynus cultripes species group, with description of a new related species (Anura, Cycloramphidae)
Authors: CARAMASCHI ULISSES , NAPOLI MARCELO FELGUEIRAS
Published: September 2022

The revision of the O. cultripes species group is presented, through the definition and characterization of O. cultripes, theredescription of O. carvalhoi based on recently collected specimens, and the description of a new species. Odontophrynusmonachus sp. nov. is described from the headwaters of the São Francisco River, in the Parque Nacional da Serra da Ca-nastra (20o 10'S, 46o 30'W, 1350 m above sea level), Municipality of São Roque de Minas, State of Minas Gerais, Brazil. The geographic distributions of the referred species are described and mapped.
Two new species of Austrotinodes Schmid (Insecta, Trichoptera, Ecnomidae) from southeastern Brazil
Authors: CAVALCANTE BRUNA MARIA DA SILVA , DUMAS LEANDRO LOURENÇO , NESSIMIAN JORGE LUIZ
Published: September 2022

The genus Austrotinodes Schmid, with 55 species described from the New World and Australia, is the second largest genus of the family Ecnomidae. Herein, we describe and figure two new species of Austrotinodes from Parque Nacional da Tijuca, Rio de Janeiro state, southeastern Brazil: A. carioca sp. nov. and A. quintarellii sp. nov.
Parapsilorhynchus alluriensis, a new species of cyprinid fish (Teleostei: Cyprinidae) from the Eastern Ghats, of India
Authors: JADHAV S. S. , KARUTHAPANDI M. , CHANDRA KAILASH , JAISWAL DEEPA , DINESH K. P. , NARAHARI A.
Published: September 2022

A new species of cyprinid fish, Parapsilorhynchus alluriensis, is described from the Alluri Hills of Andhra Pradesh State, India. It is distinguished from its congeners by the combination of the following characters: A poorly-developed callous pad present behind lower lip; head deep (depth at occiput 47.3–72.3% head length, HL); body stout and deep (depth at dorsal fin origin 17.3–21.7 % standard length, SL); gape width 27.3–32.8% HL; inter-orbital space 33.9–43.2% HL; lower lip rounded; mouth opening situated very close to the anterior tip of snout; upper lip concealed by a poorly-developed rostral fold which is slightly fringed; minute papillae on rostral fold; 3 simple pectoral-fin rays; 33–34 lateral-line scales. A partial phylogeny based on the DNA Barcode COI gene suggests a sister-group relationship between the new species and P. prateri. Till date, the genus consists of four species from the Western Ghats, three from the Eastern Ghats, including the species described herein totaling it to seven from the peninsular India.
Case series: acupuncture-related pneumothorax
Authors: Th’ng Francesca , Rao Kailing Adriel , Huang Po Yu
Published: September 2022

Background

Acupuncture has become a more popular complementary and alternative medicine worldwide. As pneumothorax is a rare acupuncture-related adverse event (AE), it is thought to be under-recognized by acupuncturists and emergency physicians, and the public is often not aware of this potential AE resulting in delayed hospital presentation.

Methods

This is a case series of acupuncture-related pneumothoraces diagnosed in an emergency department (ED) in Singapore. Data was collected retrospectively from patients’ notes and prospectively from the patients over the phone.

Case presentations

Between 2017 and 2021, 4 out of 474 (0.84%) pneumothoraces were acupuncture related. Three of these patients consented to participate in this study. One patient developed bilateral pneumothoraces. All 3 patients claimed that they were not informed by the acupuncturists of potential serious AEs prior to acupuncture treatments and that they were not aware that such AE could occur. All 3 patients had reported their symptoms of chest pain and/or breathlessness to their acupuncturists post-treatment, but they were not advised to seek urgent medical attention. When the 3 patients had informed their acupuncturists about their diagnosis of pneumothorax, 2 of the acupuncturists did not seem to be aware of this acupuncture-related AE.

Discussion

When pneumothorax manifests, there is a potential need for an invasive procedure and continuous monitoring as it may devolve into a life-threatening condition with cardiovascular compromise. Early medical recognition and attention are needed to ensure optimal patient outcomes. In the appropriate population cohort, a history of prior acupuncture treatments should be included as part of history-taking assessment in patients presenting with chest pain and/or breathlessness.

Conclusion

Emergency physicians should be vigilant of this potentially serious and life-threatening complication for anyone presenting with chest discomfort and/or breathlessness after recently undergoing acupuncture to ensure earlier diagnosis, management, and better patient outcome.