bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAGEMENT PUBLIC FINANCE IN THE CONDITIONS OF DYNAMIC DEVELOPMENT OF THE TOKENIZED ECONOMY OF UKRAINE
Authors: Yemelyanov Volodymyr , Ivashova Lyudmila , Antonova Lyudmila
Published: April 2024

The article highlights the results of a study of the specifics of public finance management in the context of the dynamic development of Ukraine's tokenized economy. It is substantiated that with the beginning of Russia's full-scale military aggression against Ukraine, budget revenues have significantly decreased and expenditures have begun to grow rapidly, which has led to significant imbalances in public finances and a significant increase in the budget deficit, which today has to be covered mainly from external sources. The author emphasizes that one of the alternative options for filling the budget revenues is taxation of the crypto industry, which has been developing rapidly and has become one of the TOP-5 countries in the world of cryptocurrency introduction in recent years. The author reviews the novelties of domestic legislation in the field of regulation of circulation of virtual assets and emphasis is the presence of contradictions in them with regard to the interpretation of their content and functions. The author identifies specific features of virtual assets and proves that they should be considered as an expression of the value of digital things created using the technology of a distributed ledger or other similar technology that allows their issue, transfer and storage in a decentralized manner, without the need to involve traditional financial intermediaries or centralized administrators. The author studies the global experience of taxation of virtual assets. It is substantiated that Ukraine should choose a policy of moderate regulation of the virtual asset market, capable of ensuring both budget revenues and control over the income from transactions with virtual assets. The author develops proposals for accelerating the introduction of the mechanism of taxation of virtual assets turnover as one of the alternative sources of formation of the state revenues of the country and successful implementation of the policy of moderate regulation of the virtual assets market.
APPLICATION OF PROGRESSIVE MANAGEMENT THEORIES FOR THE DEVELOPMENT OF THE MODERN UKRAINIAN MANAGEMENT MODEL
Authors: Verba Svitlana
Published: April 2024

The importance of public management, especially in transitional systems or emergency situations, the problem of institutional adaptability to the realities of management has a priority basis. Of course, the development of a management approach in public administration should not be considered as a panacea, it also has quite fundamental limitations arising from the remaining rather serious differences between management in public and commercial organizations and the criteria for evaluating their performance. Thus, in public institutions, such a criterion, along with efficiency and effectiveness, is social justice, which has a valuable nature that goes beyond management.

In addition, there is one fundamental difference related to the huge impact of politics on public administration, without taking into account public management turns into only a rather narrow set of management technologies, the application of which can have rather limited consequences. Traditional management was built only on the principles of bureaucracy, while modern management is oriented towards adaptive systems that can create innovations in response to today's challenges.
4,4-Dimethylsterols Reduces Fat Accumulation via Inhibiting Fatty Acid Amide Hydrolase In Vitro and In Vivo
Authors: Zhang Tao , Xie Liangliang , Guo Yiwen , Wang Zhangtie , Guo Xin , Liu Ruijie , Jin Qingzhe , Chang Ming , Wang Xingguo
Published: April 2024

4,4-Dimethylsterols constitute a unique class of phytosterols responsible for regulating endogenous cannabinoid system (ECS) functions. However, precise mechanism through which 4,4-dimethylsterols affect fat metabolism and the linkage to the ECS remain unresolved. In this study, we identified that 4,4-dimethylsterols, distinct from 4-demethseterols, act as inhibitors of fatty acid amide hydrolases (FAAHs) both in vivo and in vitro. Genetic ablation of FAAHs (
faah-1
) abolishes the effects of 4,4-dimethylsterols on fat accumulation and locomotion behavior in a
Caenorhabditis elegans
model. We confirmed that dietary intervention with 4,4-dimethylsterols in a high-fat diet (HFD) mouse model leads to a significant reduction in body weight (>11.28%) with improved lipid profiles in the liver and adipose tissues and increased fecal triacylglycerol excretion. Untargeted and targeted metabolomics further verified that 4,4-dimethylsterols influence unsaturated fatty acid biosynthesis and elevate oleoyl ethanolamine levels in the intestine. We propose a potential molecular mechanism in which 4,4-dimethylsterols engage in binding interactions with the catalytic pocket (Ser241) of FAAH-1 protein due to the shielded polarity, arising from the presence of 2 additional methyl groups (CH
3
). Consequently, 4,4-dimethylsterols represent an unexplored class of beneficial phytosterols that coordinate with FAAH-1 activity to reduce fat accumulation, which offers new insight into intervention strategies for treating diet-induced obesity.
Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
Authors: Xiong Weichen , Chai Jinwei , Wu Jiena , Li Jiali , Lu Wancheng , Tian Maolin , Jmel Mohamed Amine , Ippel Johannes H. , Kotsyfakis Michail , Dijkgraaf Ingrid , Liu Shuwen , Xu Xueqing
Published: April 2024

Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction. Although Cathelicidin can alleviate sepsis, its role in sepsis regulation remains largely unexplored. In this study, we identified Cath-HG, a novel Cathelicidin from
Hylarana guentheri
skin, and analyzed its structure using nuclear magnetic resonance spectroscopy. The modulatory effect of Cath-HG on the symptoms of mice with sepsis induced by cecal ligation and puncture was evaluated in vivo, and the platelet count, degree of organ damage, and microthrombosis were measured. The antiplatelet aggregation activity of Cath-HG was studied in vitro, and its target was verified. Finally, we further investigated whether Cath-HG could regulate thrombosis in vivo in a FeCl
3
injury-induced carotid artery model. The results showed that Cath-HG exhibited an α-helical structure in sodium dodecyl sulfate solution and effectively reduced organ inflammation and damage, improving survival in septic mice. It alleviated sepsis-induced thrombocytopenia and microthrombosis. In vitro, Cath-HG specifically inhibited collagen-induced platelet aggregation and modulated glycoprotein VI (GPVI) signaling pathways. Dot blotting, enzyme-linked immunosorbent assay, and pull-down experiments confirmed GPVI as the target of Cath-HG. Molecular docking and amino acid residue truncations/mutations identified crucial sites of Cath-HG. These findings suggest that GPVI represents a promising therapeutic target for sepsis, and Cath-HG may serve as a potential treatment for sepsis-related thrombocytopenia and thrombotic events. Additionally, identifying Cath-HG as a GPVI inhibitor provides insights for developing novel antithrombotic therapies targeting platelet activation mediated by GPVI.
Evaluation of the causes and diagnosis of acute hepatitis in children admitted to Tabriz Children Hospital
Authors: Abdinia Babak , Shoaran Maryam , Abdollahi Orang , Golchinfar Zahra
Published: April 2024

Introduction: The hepatotropic viruses are the most common causes of hepatitis worldwide; however, other infectious and non-infectious reasons can play a role in disease progress. In this study, we examined the infectious and non-infectious causes, and diagnoses of clinical signs of acute hepatitis in children admitted to Tabriz Children Hospital. Methods: In this study, the files of the children hospitalized between 2006 and 2016 with acute viral and non-viral clinical signs were extracted in Tabriz Children Hospital and patients’ information including age, sex, place of residence, type of disease, and their recovery status were investigated. Results: Of all patients, 62 were boys (48.4%) and the mean age of the hospitalized children was 6.92±0.46 years. The most common cause was hepatitis A, followed by autoimmune hepatitis. There was no significant relationship between age, gender, and place of residence with diagnosis, but there was a significant relationship between diagnosis and hepatitis type. Conclusion: The most common type of hepatitis in our study was hepatitis A, and according to its method of transmission, observing health tips is of high significance. Based on the obtained results, autoimmune hepatitis is chronic and requires long-term follow-up.
Sosyal Medya ve Sosyal Medya Kaynaklı Haksız Rekabetten Doğan Sorumluluk
Authors: Bozgeyik Hayri , Avcı Zehra
Published: April 2024

İnternetin yaygınlaşması, özellikle sosyal medyanın hızla büyümesiyle birlikte iletişimi kolaylaştırmış ve çeşitlendirmiştir. Bu platformlar kullanıcılara içerikleri paylaşma ve etkileşime geçme imkânı sunarak dünya genelinde yaygın bir etkileşim sağlamıştır. Fikri mülkiyet haklarına ve haksız rekabete yönelik ihlallerin meydana gelmesi de kaçınılmaz olmuştur. Çalışmada öncelikle sosyal medyanın tanımı ve unsurları ele alınacaktır. Haksız rekabetin genellikle istenmeyen e-posta gönderimi, alan adları, reklam araçları ve iletişim yoluyla meydana geldiği görülür. Bu ihlaller, Türk Ticaret Kanunu'nun 55. maddesi kapsamında değerlendirilir. Sosyal medyada haksız rekabet durumunda sorumluluğun içerik sağlayıcıya mı yoksa yer, erişim veya toplu kullanım sağlayıcıya mı ait olduğu önem arz eder. İçerik sağlayıcılar sundukları içerikten sorumlu olup, bağlantı sağladıkları diğer içerik sağlayıcılarından sorumlu değillerdir. Ancak, içeriği benimsedikleri durumda genel hükümlere göre sorumluluk taşırlar. Yer ve erişim sağlayıcıların sorumluluğu, kullanıcının paylaştığı hukuka aykırı içerikleri belirli kurallar çerçevesinde yönetmekle sınırlıdır. Toplu kullanım sağlayıcılarının sorumluluğu ise ticari amaçlarına göre değişmektedir. Ticari olmayan sağlayıcılar sadece suç içeren içeriklere erişimi engellemekle sorumludur, ancak ticari amaçlı sağlayıcılar çocukların korunması ve suçların önlenmesi amacıyla belirlenen prosedürlere uymakla yükümlüdürler. Sorumluluklarını yerine getirmeyenler, belirli koşullar altında sorumlu tutulabilirler.
An Integrated Review of Difficulties and Response Strategies
Experienced by Korean Nurses during the COVID-19 Outbreak: Based on
Qualitative Research
Authors: YOU Jayoung , CHO Dan Bi
Published: April 2024

Since the end of 2019, thousands of healthcare professionals worldwide have lost
their lives due to COVID-19 infections. In South Korea too, healthcare
professionals have experienced various physical and psychological difficulties
stemming from COVID-19 infections. The purpose of this study was to
comprehensively analyze the difficulties, responses, and changes in experience
of Korean nurses during the recent COVID-19 pandemic. Using the integrated
literature review method suggested by Whittemore and Knafl, qualitative research
papers on the experiences of Korean nurses during the COVID-19 pandemic were
analyzed. A total of nine documents were selected, and the experiences of nurses
during the COVID-19 pandemic were classified in terms of the difficulties they
encountered, their responses, and other relevant changes. The main finding of
this study is that Korean nurses underwent severe physical and mental stress
during the COVID-19 pandemic. This finding suggests that plans should be
developed now, both by governments and medical institutions, to provide better
support and protection to nurses in the event of future pandemics.
Structural And Mechanical Properties Of Oils From The Muradkhanly And Sangachal-Deniz Fields Of Azerbaijan
Authors: Rzayev Yusif , Osmanova Sevinj , Ismailov Etibar
Published: April 2024

In the range of 278-293 K, the structural-mechanical properties of high-viscosity asphaltene-resinous and highly solidifying paraffinic oils of the Muradkhanly and Sangachal-deniz fields of Azerbaijan, which exhibit abnormal viscosity at various shear rates and are characterized by non-Newtonian, viscoplastic and thixotropic properties, have been studied. According to the Eyring-Frenkel equation, the activation energies of the viscous flow Ea and the change in the entropy ΔS of these oils are calculated for the indicated temperature range. Various algorithms for estimating the thermodynamic parameters of the flow ΔH and ΔS published in the literature are analyzed, and the scatter of the values of the estimates of parallel calculations is shown. It is shown that with a decrease in temperature, phase transitions in oils are activated, in particular, for the highly solidifying paraffin oil Sangachal-deniz, it originates from 297 K. For the oils under consideration for the selected shear rate of 64 s-1, the values of the temperature of the beginning of structure formation, static and limiting dynamic shear stresses were determined: for Muradkhanly oil T = 282.83 K, Sangachal-deniz - T = 297.23 K. The results obtained can be used to predict the behavior of oils.
Quality of life of institutionalized older adults. Quasi- experimental study in a residential center in Tlaltenango, Mexico
Authors: MORALES-MARTÍNEZ Mario Alberto , REYNOSO-LUNA María Gabriela , GONZÁLEZ-SANDOVAL Daniela
Published: April 2024

This chapter presents the results of a study that sought to
modify the level of quality of life reported by older adults
institutionalized in a residential center. A quasiexperimental study of repeated measures was carried out,
without a control group. The study was carried out in three
stages. First, users were evaluated using the WHOQOLOLD BREF scale. Second, they were provided with
treatment to modify their quality of life. Third, they were
re-evaluated using the same scale. Adults in the care home
reported a low level of quality of life before treatment.
After treatment the levels increased. The Student t test was
applied to compare the scores reported by the study
participants before and after treatment. The result of this
test allows us to attribute a statistically significant increase
in quality of life to the treatment developed. This result is
relevant in practical terms, because it partially suggests
that the treatment is effective and can be expanded for
clinical purposes.
Evaluating the Effects of Acute and Chronic Doxorubicin Administration on Cardiac Function Through Electrocardiographic Measurements
Authors: Gökçe Yasin , Danışman Betül , Cicek Betul
Published: April 2024

Background: The medications used to treat cancer can lead to cardiac problems, which restricts their use. Furthermore, the method these medications are taken seems to have an impact on varied out-comes. Therefore, this study aimed to examine whether administering doxorubicin (DOX) agent acutely and chronically has distinct impacts on the electrical activity of the heart.
Materials and Methods: Twenty-six male Wistar-Albino rats, weighing between 200-250 grams, were split into three groups: control group; no treatment was applied to animals (n=8), DOX acute group: a single dosage of 15.05 mg/kg of DOX was given at the end of the 3 weeks (n=8), DOX chronic group; which received an intraperitoneal (i.p.) 2.15 mg/kg DOX for 3 weeks, 7 doses in total (n=10). At the end of the experimental period, electrocardiogram (ECG) measurements were taken for all animals and evaluated.
Results: ECG data showed that heart rate (HR), P wave amplitude, and P duration did not differ between the acute and control groups but did statistically significantly declined in the chronic group. In both DOX groups, PR interval remained unchanged compared to the control. Also, RR interval increased significantly in the chronic group while it remained unchanged in the acute DOX dose group. The QRS duration was found to have considerably increased in both DOX groups. Furthermore, it was found that both DOX groups had a considerable increase in the QT interval, although the chronic group's increase was more noticeable.
Conclusions: In conclusion, it is thought that the ways in which these medications are administered may result in significant variations in heart function. Acute DOX treatment appears to be less harmful than chronic exposure, as evidenced by its lack of adverse effects, particularly on P wave amplitude (a measure of atrial contraction) and P wave duration (the length of the contraction). However, more research is required to validate these findings.

Key Words: Electrocardiogram (ECG), Doxorubicin (DOX), Cardiotoxicity
Mujeres, padecimiento mental y violencias por razones de género: Derechos humanos y acceso a justicia
Authors:   , Bega Martínez Renata
Published: April 2024

A lo largo de estas paginas, en relacion al trabajo de tesis final de la Maestria en Derechos HUmanos, destacamos el análisis critico, el enfoque de derechos humanos y la perspectiva de género y feminista que atraviesan de manera transversal el contenido, así como el interés y foco en las mujeres con padecimiento mental que sufren situaciones de violencias por razones de género. Daremos inicio a la investigación con un análisis general de lo que entendemos por los términos y nociones adoptadas, así como la normativa que lo recoge. Para luego realizar un análisis situado en el Partido de La Plata, con un recorte temporal a partir del año 2014 desde donde se aplica la reglamentación de la Ley del Derecho a la Protección de la Salud Mental (de aquí en adelante LNSM) Nº 26.657); que se centre en las políticas públicas actuales, la protección jurídico-normativa y las barreras concretas que impiden garantizar promover y respetar los derechos humanos de las mujeres mencionadas (así como la posible violación a derechos humanos), sobre todo en el acceso a justicia, mediante los servicios de justicia y de salud.
Crystallization conditions of olivine in dunites the Guli massif, Siberian platform
Authors: Simonov V.A. , Kotlyarov A.V. , Sharygin V.V. , Vasiliev Yu.R.
Published: April 2024

Crystallization conditions of olivine in dunites of the Guli massif (Siberian Platform) are established using petrological, geochemical, mineralogical and thermobarogeochemical methods. The formation of olivine and chromite from picrite-meimechite ultramafc magmas was followed by the fractionation of clinopyroxenes from basaltic systems with the formation of residual high-alkaline melts. The calculations in PETROLOG and COMAGMAT programs based on the compositions of inclusions and minerals, as well as using olivine-spinel geothermometer, showed that a magmatic system, which was responsible for the formation of dunites of the Guli massif, evolved during the crystallization of olivine in a wide temperature range of 1520–1250 °C in a magma chamber at a depth of about 17 km.
Types of gold placers of the Amyl-Sistighem placer region, West Sayan
Authors: Khertek Ch.M. , Sazonov A.M.
Published: April 2024

Native gold from seven placers of the Amyl-Sistighem ore placer region (the Republic of Tyva, Krasnoyarsk region) is classifed on the basis of its structure, morphology and chemical composition, which are studied by optical and electronic microscopy. Three chemical types of native gold are identifed: Ag-Au, Hg-Ag-Au, Cu-Ag-Au. There are rounded and angular particles with and without a high-fneness rim. Seventeen types of native gold are established on the basis of combination of various characteristics. These varieties characterize the mineralogical-geochemical types of primary ores, the distance of the transportation of clastic material, the degree of mechanogenic and crystallophysical deformations of gold particles, and the duration of their occurrence in a gold-bearing layer under relatively calm conditions. Our results can be used in planning thematic pre-project and prospecting-assessing work at this territory, whereas methodological issues can be applied in other gold placer areas.
Processing of gypsum-bearing materials in the bronze age Gonur Depe archeological site (Southeast Karakum Desert)
Authors: Kabanova L.Ya. , Yuminov A.M. , Blinov I.A.
Published: April 2024

The technology of preparation of an ancient binder mixture used in construction work at the Gonur Depe archeological site (Southeast Karakum desert) is interpreted on the basis of study of its mineral composition and textural-structural features. The material is composed of thin prismatic-angular and fbrous aggregates of reduced gypsum (60–70 %) and β-bassanite (3 %) enclosed in clay-siliceous matrix (20–30 %). The mixture also contains grains of quartz (5–10 %), feldspar (up to 1%), mica (up to 1 %) and other minerals. The mixture was produced from a crushed natural gypsum stone, which was calcinated in air. In this case, gypsum is converted to β-bassanite and partly to anhydride. The morphology and sizes of mineral particle confrm the presence of the calcination stage up to 200 °C. The further addition of water to a dry mixture caused rapid thickening and cementation of the material, which could be used for whitewashing and plastering of the walls.
PENGARUH KEMAMPUAN BERPIKIR KREATIF TERHADAP HASIL BELAJAR MATEMATIKA SISWA PADA MATERI LINGKARAN
Authors: Firdaus Firda , Yudhanegara Mokhammad Ridwan , Roesdiana Lessa
Published: April 2024

Penelitian ini bertujuan untuk mengetahui adakah pengaruh kemampuan berpikir kreatif terhadap hasil belajar matematika siswa dan seberapa besarkah pengaruh kemampuan berpikir kreatif terhadap hasil belajar matematika siswa. Jenis penelitian yang digunakan adalah pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa SMP kelas VIII SMP Negeri 7 Karawang Barat. Pengambilan sampel dilakukan dengan teknik proporsionate stratified random sampling. Sampel penelitian berjumlah 132 siswa. Dalam penelitian ini pengumpulan data menggunakan instrumen tes kemampuan berpikir kreatif dan hasil Ulangan Tengah Semester (UTS) siswa. Data diolah dan dianalisis menggunakan uji regresi linear sederhana dengan menggunakan software IBM SPSS Statistics 25. Hipotesis dalam penelitian ini adalah terdapat pengaruh yang signifikan antara kemampuan berpikir kreatif terhadap hasil belajar matematika siswa pada materi lingkaran kelas VIII SMP Negeri 7 Karawang Barat. Hasil penelitian ini menunjukkan bahwa kemampuan berpikir kreatif berpengaruh secara signifikan terhadap hasil belajar matematika siswa pada materi lingkaran dengan tingkat siginifikansi  dan nilai t hitung sebesar . Adapun besar pengaruh antara keduanya yaitu sebesar 62,6 % yang ditunjukan oleh nilai koefisien deteminasi (R Square ) sebesar 0,626.
ETNOMATEMATIKA DALAM TENUN TROSO: KONTEKS PEMBELAJARAN UNTUK TRANSFORMASI GEOMETRI
Authors: Maisaroh Dewi , Permatasari Dian
Published: April 2024

Penelitian ini bertujuan untuk mengeksplorasi konsep geometri dalam motif tenun Troso dari Jepara sebagai potensi bahan ajar matematika di sekolah dasar. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan etnografi, melibatkan observasi, wawancara, dan dokumentasi terhadap batik Troso dari kabupaten Jepara, Jawa Tengah. Analisis data menggunakan metode Miles dan Huberman (1992). Hasil penelitian menunjukkan bahwa motif-motif tenun Troso dapat dijadikan alat bantu pembelajaran geometri untuk siswa SMP. Motif-motif tersebut melibatkan konsep transformasi geometri seperti translasi, rotasi, refleksi, dan dilatasi. Setiap motif melibatkan konsep transformasi geometri tertentu, seperti translasi pada motif tenun bulu, rotasi pada motif tenun rewoven, dan refleksi pada motif tenun blanket. Eksplorasi sifat-sifat transformasi bisa dilakukan dengan memperhatikan motif-motif tersebut. Motif-motif kain tenun Troso memberikan kontribusi pada pemahaman siswa terhadap konsep-konsep transformasi geometri, sesuai dengan Kurikulum Merdeka kelas VII SMP/MTs.
PENGEMBANGAN MEDIA KHS MATERI PHBS TENTANG MAKANAN SEHAT SISWA KELAS I SD MUHAMMADIYAH MRISI
Authors: Setyawan Feri Budi , Sari Ayu Puspita
Published: April 2024

Interaksi antara pendidik dan peserta didik dapat menghasilkan proses pembelajaran yang baik melalui media KHS (Kunci Hidup Sehat) yang merupakan media visual diam berisikan macam-macam gambar, pengertian, dan manfaat (sayur, buah, lauk pauk, dan makanan pokok). Tujuan penelitian untuk menjelaskan dan mendeskripsikan kualitas media KHS berdasarkan pendapat para ahli dan respon siswa. Jenis metode penelitian R&D (Research and Development) dengan menggabungkan dua jenis penelitian kuantitatif dan kualitatif. Teknik pengumpulan data wawancara, observasi, angket, dan dokumentasi. Model pengembangan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Objek penelitian di SD Muhammadiyah Mrisi dan subjek penelitian kepala sekolah, guru, dan siswa kelas I. Hasil penelitian menunjukkan bahwa penilaian media didapatkan nilai rata-rata 93,33 kategori “sangat baik”, ahli materi didapatkan nilai rata-rata 91 kategori “sangat baik”, dan ahli bahasa didapatkan nilai rata-rata 88 kategori “sangat baik”. Skor keseluruhan dari validasi ahli 272,33 dengan rata-rata nilai 90,77 kategori “sangat baik” digunakan uji coba. Setelah media diuji cobakan mendapat jumlah keseluruhan 112 dengan rata-rata nilai 100 kategori “sangat baik”. Dinyatakan media KHS materi PHBS tentang makanan sehat siswa kelas I SD Muhammadiyah Mrisi memiliki kualitas sangat baik digunakan untuk media belajar bagi guru dan siswa.
SINERGI PENDIDIKAN JASMANI DAN TEKNOLOGI MULTIMEDIA DI ERA DIGITAL
Authors: Syafruddin Muhammad Akbar , Anwar Nur Indah Atifah
Published: April 2024

Pemanfaatan teknologi informasi dan komunikasi membuat peran teknologi dalam pendidikan menjadi sangat penting. Dengan bantuan berbagai aplikasi untuk pendidikan, sangat membantu bagi guru maupun siswa. Mereka dapat melihat manfaat teknologi pendidikan tanpa pernah bertemu langsung. Multimedia adalah bagian yang sangat penting dari topik ini. Kajian ini mencoba memberikan garis besar bagaimana dan mengapa teknologi multimedia penting dalam pendidikan jasmani. Data dari arteknologi multimediael ini dikumpulkan melalui google scholar dengan kata kunci teknologi dalam pendidikan. Kesimpulannya Teknologi multimedia mendorong siswa untuk bekerja secara mandiri, dan ketersediaan teknologi modern yang luas membuat siswa lebih mungkin untuk belajar dengan kondisi jarak jauh.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA PEMBELAJARAN TEKS DEBAT SISWA KELAS X
Authors: Putri Adinda Insani
Published: April 2024

Pesatnya perkembangan IPTEK pada dunia pendidikan di abad 21, mengharuskan seorang guru dapat menyesuaikan bahan ajar dan madia pembelajaran yang digunakan. Salah satu media pembelajaran yang sesuai dengan karakteristik pembelajaran di abad 21 yaitu penggunaan media pembelajaran berbasis android. Dengan mempertimbangkan permasalahan yang ada,penelitian ini bertujuan untuk memberikan salah satu amedia pembelajaran  yang dapat membantu seorang pendidik dan juiga peserta didik dalam pembelajaran Bahasa Indonesia khusunya dalam pembelajaran teks debat. Metode penelitian yang digunakan pada penelitian ini yaitu metode penelitian Research and Development dengan mengacu pada model Sommerville. Teknik pengumpulan data pada penelitian ini menggunakan teknik deskriptif kualitatif. Hasil dari pengembangan media pembelajaran berbasis android yaitu terciptanya salah satu aplikasi Kelas Debat yang mengacu pada permasalahan yang ada pada Siswa SMKelas X
PENGARUH KESIAPAN BELAJAR DAN DUKUNGAN ORANG TUA TERHADAP KEPERCAYAAN DIRI ANAK
Authors: Kuswantini Yogi , Priyanti Nita
Published: April 2024

Permasalahan kepercayaan diri menjadi tantangan tersendiri bagi anak usia dini atau prasekolah. Bersiap-siap memasuki usia sekolah, anak usia dini membutuhkan kemampuan beradaptasi yang baik terhadap berbagai perubahan yang terjadi. Kemampuan beradaptasi terhadap perubahan lingkungan, interaksi sosial, dan tuntutan akademis membutuhkan kepercayaan diri anak. Peran orang tua dianggap penting untuk memberikan dukungan bagi terbangunnya kepercayaan diri anak. Demikian pula dengan kesiapan belajar anak yang dianggap penting untuk membangun kepercayaan diri mereka dalam beradaptasi. Penelitian dengan pendekatan kuantitatif ini bertujuan mengungkapkan pengaruh kesiapan belajar dan dukungan orang tua terhadap kepercayaan diri anak usia dini. Data penelitian diperoleh melalui kuesioner dan diolah dengan menggunakan perangkat lunak SPSS V26.0 for Windows.  Sebelum pengujian hipotesis, dilakukan uji validitas, reliabilitas, dan normalitas data. Pembuktian hipotesis menunjukkan adanya pengaruh kesiapan belajar dan dukungan orang tua terhadap kepercayaan diri anak usia dini. Dari regresi linier berganda diperoleh hasil bahwa variabel bebas, baik kesiapan belajar maupun dukungan orang tua secara parsial berpengaruh positif dan signifikan terhadap variabel terikat kepercayaan diri (uji t). Kesiapan belajar dan dukungan orang tua secara simultan berpengaruh positif dan signifikan terhadap kepercayaan diri (uji F). Kesiapan belajar dan dukungan orang tua memiliki kontribusi sebesar 55,2% terhadap kepercayaan diri (uji koefisien determinasi)
Methodological characteristics of statistical support of regional innovation policy
Authors: Dvas G. V. , Busheneva Yu. I.
Published: April 2024

Aim. To identify the possibilities of expanding the general sample of organizations involved in the provision of statistical data regarding the issues of innovation activity implementation to improve the quality of information in decision-making within the framework of regional innovation policy implementation.

Objectives. To determine the significance of statistical information for the processes of strategic planning in the country and regions; to identify the problems of adequate reflection of innovation activity in modern Russian statistics; to establish the deviations of the methodological apparatus of Rosstat from the recommendations of the Oslo Manual; to analyze some statistical parameters of innovation activity in the regions of the North-West of Russia; to develop recommendations for changing the approaches of Rosstat to the organization of statistical observation in the sphere of innovation activity.

Methods. The article characterizes the state of innovation statistics in the country on the basis of analysis methods. The method of pair correlation allowed to reveal the inconsistency of the parameters of innovation activity of organizations with the key economic indicators of regional development.

Results. The authors have identified two main directions of expanding the general sample of organizations when conducting innovation statistics: a larger-scale inclusion of service sector enterprises in the list of surveyed organizations and a decrease in the number of personnel of organizations, starting from which organizations are obliged to provide statistical information on the issues of innovation activity, from 15 to 10 people. In addition, the article substantiates the necessity of applying in Russia the subject approach to the statistical survey of innovation activity of enterprises, which contributes to the identification of factors that affect the innovation activity of organizations, and the assessment of such an impact, taking into account regional characteristics.

Conclusions. The change of approaches to innovation statistics will provide the authorities in the regions with correct information for more effective realization of regional innovation policy.
Hierarchical classification of entrepreneurial risks
Authors: Yulgushev A. M.
Published: April 2024

Aim. Improvement of the hierarchical classification of entrepreneurial risks.

Objectives. Justification of the relevance of modernization of the hierarchical classification of entrepreneurial risks, coverage of this problem and the experience of its solution in the scientific community; selection of the most acceptable classification of entrepreneurial risks and search for its weaknesses; introduction of new classes and determination of their place in the hierarchical classification of entrepreneurial risks; addition of existing classes of entrepreneurial risks; visualization of cause-and-effect relations between the elements of the hierarchical classification of entrepreneurial risks; argumentation of the following aspects of the hierarchical classification of entrepreneurial risks.

Methods. The author applied the system approach, methods of logical analysis, synthesis, induction and deduction, as well as situational modeling and classification.

Results. On the basis of the known researches the hierarchical structure, interconnected system of entrepreneurial risks is selected and supplemented. The class “Economic risks” was supplemented: the place and interrelations of transportation risks in the classification of the upper level were established. The class “Personnel risks” has been expanded: the place and interrelations of risks of reduction of personnel potential of the company have been determined. The scheme of influence of factor risks on decrease of personnel potential of the company is developed, and also causal relations are grounded. The architecture of the “Financial Risks” class is enriched with six risks. They include interest and credit risks, settlement risk, risk of solvency loss, risk of lost profit, risk of non-payment on commercial transactions and risk of loss of competitiveness. A new class in the system classification of top-level entrepreneurial risks “Digital Risks” is supplemented and described. The structural definitions are singled out, the place and interrelations of the proposed class are determined. The author proposed the place of the risk of reduction of innovation potential outside the classes, opening the prospect of considering a new class of the upper level.

Conclusions. Risk management should have a regular and systematic character. Classification as an element of entrepreneurial risk management requires updating and modernization in connection with new challenges in the business environment. The article substantiates the scientific and practical significance of the outlined approach.
Pengaruh Iklan Obat Bebas Non Resep di Televisi Terhadap Perilaku Swamedikasi pada Penggunaan Obat Pereda Gejala Flu di Jawa Barat
Authors: Hadi Ezra Aurelia Glenia , Destiwati Rita
Published: April 2024

Iklan obat disiarkan melalui televisi secara persuasive menjual produk obat dengan memberikan informasi mengenai obat dan kesehatan sehingga khalayak memiliki ketertarikan dan kepercayaan dalam memilih produk obat tersebut kemudian membelinya untuk melakukan tindakan swamedikasi. Swamedikasi atau pengobatan sendiri ini adalah keadaan ketika seseorang menggunakan obat-obatan untuk mengatasi penyakit atau gejala yang mereka kenali. Adapun tujuan penelitian ini ialah untuk mengukur besar pengaruh iklan obat bebas non resep yang ditayangkan pada televisi dengan perilaku swamedikasi pada penggunaan obat pereda gejala flu non resep di Jawa Barat. Metode penelitian yang digunakan ialah regresi linear sederhana dengan menguji normalitas, uji determinansi data, serta uji hipotesis. Diperoleh hasil yang signifikan dari pengujian terhadap variabel dependen dan independen. Kesimpulannya ialah iklan obat di televisi mempengaruhi masyarakat dalam mengobati dirinya sendiri khususnya dalam penanganan gejala flu. Dengan begitu, iklan sebagai media komunikasi pemasaran suatu perusahaan obat telah berhasil mencapai tujuan dan fungsi dari iklan itu sendiri.
"Black-Scholes-Artificial Neural Network": A novel option pricing model
Authors: Shahvaroughi Farahani Milad , Babaei Shiva , Esfahani Amirhossein
Published: April 2024

Purpose: This study conducts a comparative study of various options pricing models and introduces a new model.
Research methodology: This paper reviews eight option pricing models, including the Black-Scholes-Merton model (BSM), Monte Carlo simulation (MC), Heston, GARCH, Lattice, Jump Diffusion models (JDM), Normal Inverse Gaussian-Cox-Ingersoll-Ross Model, and a novel model called Black-Scholes-Artificial Neural Network (BSANN). The objective is to predict the European call and put options using a payoff calculation. The underlying asset is Khodro, a famous automobile producer company in Iran, for the last year. The daily prices were also used as historical data. The primary software used for the calculations and plots was MATLAB. An Excel option pricing toolbox was used to obtain more accurate and improved results.
Results: Based on the results, it can be concluded that the proposed model, BS-ANN, provides the most accurate estimation with the lowest standard deviation.
Limitations: There are several limitations to be considered when choosing an underlying asset. An important factor is the availability of sufficient data on the number of shared transactions. Another limitation of this study is the absence of trading halts. Additionally, caution is crucial when selecting an appropriate number of estimated parameters.
Contribution: By utilizing the presented model, researchers, individuals, investors, and stock market analysts interested in trading can enhance their estimations.
Novelty: The most significant novelty of this study is the presentation of a hybrid model incorporating unique features.
Overview of Brown-Sequard Syndrome.
Authors: Sharon Evelyn , Keerthanashree RNP
Published: April 2024

A neurologic syndrome called Brown-Séquard syndrome is brought on by spinal cord hemisection. On the side of the body, ipsilateral to the lesion, it presents as weakness or paralysis, proprioceptive abnormalities, and loss of pain and temperature perception. Brown-Séquard syndrome is an incomplete spinal cord syndrome with a range of severity in its clinical presentation.

     One of the most intricate and fascinating areas of the nervous system to study is the spinal cord. Its overwhelming clinical presentation, development problems, lesions, and intricate connections call for a deeper comprehension of its anatomical and physiological makeup.

     Like the brain, the extremely fragile and sensitive spinal cord is well-protected by the robust bony cage comprising the vertebral arch and vertebral bodies. Together, they create the spinal hollow, or long spinal column, which houses the spinal cord. Millions of neurons reside in the spinal cord, and their bundled fibers run as ascending or descending tracts. Thirty-one pairs of spinal nerves, primarily supplying the trunk and limbs, emerge from the spinal cord. These are mixed spinal nerves with a motor component that assists in controlling the trunk and voluntary muscles in all limbs. Additionally, they have a sensory component that aids in taking in the sensory data from these regions. Therefore, for a better understanding of the clinical presentation and its pathology in any spinal cord lesion, it is imperative to grasp the fundamentals of anatomy.

      In this short review, we have discussed the symptoms, management, and prevention of brown syndrome.
A CASE OF LONG ANO-SCROTAL FISTULA PRESENTING AS A PRIMARY SCROTAL DISCHARGE AND ITS MANAGEMENT BY FISTULECTOMY AND PRIMARY CLOSURE.
Authors: Noor Mohiddin MD. M. M. , Fazila Banu Shaik
Published: April 2024

Introduction: Fistula-in-ano is an anorectal condition prevalent in the population worldwide. It is an inammatory track
lined by granulation tissue which connects perianal skin supercially to anal canal; anorectum or rectum deeply. It is
characterised by chronic purulent discharge or cyclical pain associated with abscess formation followed by intermittent spontaneous
decompression. In some cases of men with anal stulas, the stula can extend into the scrotum, in which case the scrotum is usually painful and
presents with redness, swelling and pus discharge from the external opening that is the secondary scrotal orice of the stula and can sometimes be
misdiagnosed as scrotal abscess. Fistula with extension into scrotum is one of the rare complications of stula. Nearly about 82% ano-scrotal
stulas had anterior opening and they are mostly intersphincteric or transsphincteric stulas.
ENTREPRENEURIAL OPPORTUNITIES: INNOVATION THROUGH HAND STITCHES
Authors: Agrawal Rinku , Sharan Madhu
Published: April 2024

Hand stitching, a craft that was practiced for constructing garments in ancient times has lost its demand due to the advent
of machines. More and more people get engaged in the use of machines rendering hand-stitching obsolete, as it is
strenuous and time-consuming compared to machine stitching. The handcrafted garments do hold a good potential with the use of the right
techniques to assemble and embellish them. This research was taken up to examine the fundamental qualities of hand stitches and their use for
creative clothing seams, surface ornamentation, and decorative elements. Running stitches were explored at length for variation to be used for
both decoration as surface ornamentation and seam construction. The researcher also trained the women without formal education in three
sessions so that they could convert the skill for economic independence. The results were so encouraging that self-help groups for women were
established where they learned the variety of basic hand stitches for ornamental purposes, which added to the value of the garments. The
reversible elements that can be worn on either side of the garment were designed. As the extension of the work, designs (motifs) were prepared by
the researcher and developed by the trainees, which were prepared to keep in mind the commercial market.
HYPER IgE SYNDROME – A CASE REPORT.
Authors: Irfani Shaik , BI P. Fathima
Published: April 2024

Hyper IgE Syndrome is a group of primary immunodeciency
disorders with overlapping and distinct immunologic and non -
immunologic features . It has two types of presentations. Type 1 is an
autosomal dominant disorder with STAT 3 mutation. Type 2 is an
autosomal recessive type with DOCK 8 mutation.
ENHANCING DISASTER RESILIENCE: A COMPREHENSIVE ANALYSIS OF THE MAHARASHTRA STATE DISASTER MANAGEMENT PLAN 2023
Authors: Uttam Chothe Ashok , Garudkar Vikas Rangnath
Published: April 2024

Disasters pose signicant threats to communities, economies, and ecosystems, necessitating the development and
implementation of robust disaster management plans. Maharashtra, a state with diverse geographical and demographic
characteristics, has recently formulated its State Disaster Management Plan (SDMP) for the year 2023. This research paper aims to critically
analyze and evaluate the key components of the Maharashtra SDMP 2023, assessing its strengths, weaknesses, and potential areas for
improvement. The study utilizes a combination of qualitative and quantitative research methods, incorporating data from ofcial documents,
expert interviews, and case studies to provide a comprehensive overview of the state's preparedness and resilience in the face of disasters.
IN SILICO STUDIES OF THE INTERACTIONS OF KEY TERPENOIDS OF ESSENTIAL OILS OF HEDYCHIUM CORONARIUM J. KOENIG, AN ENDANGERED MEDICINAL AND AROMATIC PLANT WITH MATRIX PROTEINS OF BACTERIAL BIOFILMS
Authors: Vaishali Kamath , S Suveena , Himanshu Dawda
Published: April 2024

Essential oils so far have been investigated for their use in wound healing, treating respiratory disorders, antimicrobial
and antioxidant properties. They are now looked upon as novel therapeutic agents to treat bacterial biolms. Interactions
of four key components of essential oils of Hedychium coronarium J. Koenig, an endangered, medicinal and aromatic plant with matrix proteins
viz., Self-associating proteins of Escherichia coli, with Lec B protein of Pseudomonas aeruginosa and Sortase protein of Staphylococcus aureus
were studied through molecular docking and molecular dynamics. The key components of the essential oils selected were β-carotene,
caryophyllene oxide, eucalyptol and sitosterol..All the four components showed good, stable interactions with Self-Associating Protein of
Escherichia coli. β-carotene, eucalyptol and sitosterol interactions with Lec B protein of Pseudomonas aeruginosa were also stable with the
exception of caryophyllene. In case of Staphylococcus aureus, with the exception of eucalyptol, promising results were seen with β-carotene,
caryophyllene and sitosterol. The selected essential oil components showed good stable interactions with matrix proteins through in silico results
thereby validating that natural remedies may be considered for treating fatal illnesses as well.
GIANT RENAL ANGIOMYOLIPOMA WITH EPITHELIAL CYST IN YOUNG WOMAN CAUSING ABORTION: A RARE CASE REPORT
Authors: Dutt Sharma Dinesh , Bhatnagar Rakesh , Kumar Hemant , Chitara Kunal , Akshay Akshay
Published: April 2024

Angiomyolipoma with epithelial cysts (AMLEC) is an uncommon subtype of kidney angiomyolipoma. AMLEC has a distinct histological and
immunohistochemical staining pattern, which helps in the pathological diagnosis. We present a rare case of AMLEC in a 20-year-old female,
associated with pregnancy lost, which was provisionally diagnosed as Retroperitoneal Liposarcoma on radiology and on histopathological
examination diagnosed as AMLEC. She underwent surgical intervention to relieve her symptoms and successful possibility of upcoming
pregnancy
PROSPECTIVE COMPARATIVE STUDY ON THE EFFICACIOUSNESS OF PLATELET RICH PLASMA VS. CORTICOSTEROID INJECTION IN THE TREATMENT OF CHRONIC PLANTAR FASCIITIS
Authors: Krishna Reddy K. hari , Kumar A. Sandeep , kumar reddy K. Saran
Published: April 2024

Chronic plantar fasciitis (CPF) represents a substantial cause of heel discomfort, adversely affecting the daily functioning and overall quality of life
of aficted individuals. Characterized by persistent pain emanating from the plantar fascia, CPF's pathophysiology involves microtears,
degeneration, and inammation, often attributed to repetitive stress and overuse. The condition not only presents a clinical challenge but also
contributes signicantly to patient morbidity through restricted mobility and prolonged discomfort. Traditional management strategies, including
physical therapy, orthotic support, and anti-inammatory medication, occasionally fall short in providing long-term relief, necessitating the
exploration of alternative therapeutic approaches such as platelet-rich plasma (PRP) and corticosteroid injections. This comparative study aims to
assess the efcacy of PRP against corticosteroid injections in mitigating pain and enhancing functional outcomes in CPF patients over a six-month
period. By employing a randomized control design, the investigation provides insights into the therapeutic potential of PRP, which promotes tissue
regeneration and healing, versus the primarily anti-inammatory action of corticosteroids. Preliminary results suggest that PRP injections may
offer a more sustainable reduction in pain and improvement in functionality, proposing a shift towards regenerative treatments in managing chronic
plantar fasciitis.
PURPUREOCILLIUM LILACINUM UNMASKED: THE ELUSIVE FUNGUS BEHIND SKIN MYSTERIES IN HEALTHY WARRIORS
Authors: Rana Ankita , Anand Kavita Bala , Grover Jayant , Singh Neha
Published: April 2024

Purpureocillium lilacinum, formerly Paecilomyces lilacinus, is an ubiquitous hyaline hyphomycete frequently found in soil, decaying vegetation
but is considered as an emerging human pathogen. It mainly affects immunocompromised or those who have undergone surgical procedures.
Clinical cases caused by P. lilacinum are often difcult to treat because of the intrinsic resistance of the fungus to conventional antifungal agents
and its variable susceptibility to novel triazoles. In immunocompetent hosts, infections caused by this fungus are very unusual and mainly involve
skin. Here in we present a case series of cutaneous infection due to P. lilacinum in an apparently immunocompetent patients with no co-morbidities.