bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloning and high-level expression of monomeric human superoxide dismutase 1 (SOD1) and its interaction with pyrimidine analogs
Authors: LeVatte Marcia , Lipfert Matthias , Roy Dipankar , Kovalenko Andriy , Wishart David Scott
Published: February 2021

Superoxide dismutase 1 (SOD1) is known to be involved in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS) and is therefore considered to be an important ALS drug target. Identifying potential drug leads that bind to SOD1 and characterizing their interactions by nuclear magnetic resonance (NMR) spectroscopy is complicated by the fact that SOD1 is a homodimer. Creating a monomeric version of SOD1 could alleviate these issues. A specially designed monomeric form of human superoxide dismutase (T2M4SOD1) was cloned into E. coli and its expression significantly enhanced using a number of novel DNA sequence, leader peptide and growth condition optimizations. Uniformly 15N-labeled T2M4SOD1 was prepared from minimal media using 15NH4Cl as the 15N source. The T2M4SOD1 monomer (both 15N labeled and unlabeled) was correctly folded as confirmed by 1H-NMR spectroscopy and active as confirmed by an in-gel enzymatic assay. To demonstrate the utility of this new SOD1 expression system for NMR-based drug screening, eight pyrimidine compounds were tested for binding to T2M4SOD1 by monitoring changes in their 1H NMR and/or 19F-NMR spectra. Weak binding to 5-fluorouridine (FUrd) was observed via line broadening, but very minimal spectral changes were seen with uridine, 5-bromouridine or trifluridine. On the other hand, 1H-NMR spectra of T2M4SOD1 with uracil or three halogenated derivatives of uracil changed dramatically suggesting that the pyrimidine moiety is the crucial binding component of FUrd. Interestingly, no change in tryptophan 32 (Trp32), the putative receptor for FUrd, was detected in the 15N-NMR spectra of 15N-T2M4SOD1 when mixed with these uracil analogs. Molecular docking and molecular dynamic (MD) studies indicate that interaction with Trp32 of SOD1 is predicted to be weak and that there was hydrogen bonding with the nearby aspartate (Asp96), potentiating the Trp32-uracil interaction. These studies demonstrate that monomeric T2M4SOD1 can be readily used to explore small molecule interactions via NMR.
Self-focused attention and safety behaviours maintain social anxiety in adolescents: An experimental study
Authors: Leigh Eleanor , Chiu Kenny , Clark David M.
Published: February 2021

Background

Self-focused attention and safety behaviours are both associated with adolescent social anxiety. In adults, experimental studies have indicated that the processes are causally implicated in social anxiety, but this hypothesis has not yet been tested in a youth sample.

Methods

This experiment explored this possibility by asking high and low socially anxious adolescents (N = 57) to undertake conversations under different conditions. During one conversation they were instructed to focus on themselves and use safety behaviours, and in the other they focused externally and did not use safety behaviours. Self-report, conversation partner report and independent assessor ratings were taken.

Results

Self-focus and safety behaviours increased feelings and appearance of anxiety and undermined performance for all participants, but only high socially anxious participants reported habitually using self-focus and safety behaviours.

Conclusions

The findings provide support for the causal role of self-focus and safety behaviours in adolescent social anxiety and point to the potential clinical value of techniques reversing them to treat the disorder.
Transcriptome analysis of the role of autophagy in plant response to heat stress
Authors: Zhang Yan , Min Haoxuan , Shi Chengchen , Xia Gengshou , Lai Zhibing
Published: February 2021

Autophagy plays a critical role in plant heat tolerance in part by targeting heat-induced nonnative proteins for degradation. Autophagy also regulates metabolism, signaling and other processes and it is less understood how the broad function of autophagy affects plant heat stress responses. To address this issue, we performed transcriptome profiling of Arabidopsis wild-type and autophagy-deficient atg5 mutant in response to heat stress. A large number of differentially expressed genes (DEGs) were identified between wild-type and atg5 mutant even under normal conditions. These DEGs are involved not only in metabolism, hormone signaling, stress responses but also in regulation of nucleotide processing and DNA repair. Intriguingly, we found that heat treatment resulted in more robust changes in gene expression in wild-type than in the atg5 mutant plants. The dampening effect of autophagy deficiency on heat-regulated gene expression was associated with already altered expression of many heat-regulated DEGs prior to heat stress in the atg5 mutant. Altered expression of a large number of genes involved in metabolism and signaling in the autophagy mutant prior to heat stress may affect plant response to heat stress. Furthermore, autophagy played a positive role in the expression of defense- and stress-related genes during the early stage of heat stress responses but had little effect on heat-induced expression of heat shock genes. Taken together, these results indicate that the broad role of autophagy in metabolism, cellular homeostasis and other processes can also potentially affect plant heat stress responses and heat tolerance.
Myocardial injury in hospitalized patients with COVID-19 infection—Risk factors and outcomes
Authors: Efros Orly , Barda Noam , Meisel Eshcar , Leibowitz Avshalom , Fardman Alexander , Rahav Galia , Klempfner Robert , Grossman Ehud
Published: February 2021

Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9th, 2020 to August 28thwith a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06), female sex (OR, 3.03; 95% CI 1.54–6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42–14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44–5.73). The risk for death (hazard ratio [HR] 4.32, 95% CI 2.08–8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15–3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.
High prevalence of gastroschisis in Brazilian triple side border: A socioenvironmental spatial analysis
Authors: de Souza Suzana , Nihei Oscar Kenji , Pestana Cezar Rangel
Published: February 2021

This research investigated the spatial association between socioenvironmental factors and gastroschisis in Brazilian triple side border. A geographic analysis for gastroschisis prevalence was performed considering census sector units using Global Moran Index, Local Indicator of Spatial Association Analysis and Getis Ord statistics. Sociodemographic factors included rate of adolescent and parturients over 35 years; population with no income and above 5 minimum wages; rate of late prenatal; and proximity to power transmission lines. Logistic regression models were applied to verify the association between socio-environmental factors and prevalence of gastroschisis. No global spatial correlation was observed in the distribution of gastroschisis (Moran´s I = 0.006; p = 0.319). However, multiple logistic regression showed census sectors with positive cases had higher probability to power transmission lines proximity (OR 3,47; CI 95% 1,11–10,79; p = 0,031). Yet, spatial scan statistic showed low risk for gastroschisis in southern city region (OR = 0; p = 0.035) in opposite to power transmission lines location. The study design does not allow us to attest the causality between power transmission lines and gastroschisis but these findings support the potential exposure risk of pregnant to electromagnetic fields.
Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation
Authors: Feng Yuebiao , Chen Lu , Gao Li , Dong Li , Wen Han , Song Xiumei , Luo Fang , Cheng Gong , Wang Jingwen
Published: February 2021

Repeated blood meals provide essential nutrients for mosquito egg development and routes for pathogen transmission. The target of rapamycin, the TOR pathway, is essential for vitellogenesis. However, its influence on pathogen transmission remains to be elucidated. Here, we show that rapamycin, an inhibitor of the TOR pathway, effectively suppresses Plasmodium berghei infection in Anopheles stephensi. An. stephensi injected with rapamycin or feeding on rapamycin-treated mice showed increased resistance to P. berghei infection. Exposing An. stephensi to a rapamycin-coated surface not only decreased the numbers of both oocysts and sporozoites but also impaired mosquito survival and fecundity. Transcriptome analysis revealed that the inhibitory effect of rapamycin on parasite infection was through the enhanced activation of immune responses, especially the NF-κB transcription factor REL2, a regulator of the immune pathway and complement system. Knockdown of REL2 in rapamycin-treated mosquitoes abrogated the induction of the complement-like proteins TEP1 and SPCLIP1 and abolished rapamycin-mediated refractoriness to Plasmodium infection. Together, these findings demonstrate a key role of the TOR pathway in regulating mosquito immune responses, thereby influencing vector competence.
Polymorphisms in hormone-sensitive lipase and leptin receptor genes and their association with growth traits in Barki lambs
Authors: Ibrahim Adel H. M.
Published: February 2021

Background and Aim: Marker-assisted selection has many advantages over conventional selection in animal breeding. The candidate gene approach has been applied to identify genetic markers associated with economically important traits in livestock. This study was established to investigate variation in the hormone-sensitive lipase (HSL) and leptin receptor (LEPR) genes, and their association with growth traits in Barki lambs.

Materials and Methods: Records for birth weight (BW), pre-weaning average daily gain (ADG1), weaning weight (WW), post-weaning average daily gain (ADG2), and marketing weight (MW) were obtained from 247 Barki lambs. Polymerase chain reaction–single-stranded conformational polymorphism analyses were used to detect variation in exon 9 of HSL and exon 19 of LEPR. General linear models were used to test for associations between the variation in ovine HSL and LEPR, and growth traits.

Results: The SSCP banding patterns for HSL showed three variants (H1, H2, and H3), which contained two nucleotide-sequence differences (c.1865C>T and c.2038T>C). Two SSCP banding patterns (L1 and L2) were observed for LEPR and these contained two nucleotide-sequence differences (c.2800G>A and c.2978C>G). The HSL genotype showed no effect on the studied traits. The LEPR genotype was proven to have significant effects (p<0.05) on ADG2 and MW. The presence of the L1 variant was associated (p<0.01) with decreased ADG2 and MW.

Conclusion: The finding of an association between LEPR gene variation and growth rate after weaning in Barki lambs warrants efforts to improve this trait.
Revisiting Jane Jacobs’s Urban Complexity in Global Sustainability City Discourse
Authors: Wong May Ee , Stasiowski Maciej
Published: February 2021

Since the 1990s, a recurrent trope of the ‘global sustainable city’ has emerged in popular and professional discussions of globalization, sustainable development and urban innovation. Published in commercial publications and grey literature on policy, design and global trends, the trope is also articulated in a genre of trade books by urban consultants and in public showcases that project the city as a socially, economically and environmentally beneficial entity – a sustainable complex system that is even promoted to be humanity’s best hope for solving the global ecological problems of the twenty-first century. This article traces how urbanist Jane Jacobs’s notion of urban complexity becomes an allusive reference in examples of popular global sustainability discourse that present the city as an evolutionary self-organizing entity of systemic networks and physical flows. It examines urban economist Edward Glaeser’s Triumph of the City: How Our Greatest Invention Makes Us Richer, Smarter, and Greener (2011), urbanist Leo Hollis’s Cities Are Good for You: The Genius of the Metropolis (2013) and urban strategist Jeb Brugmann’s Welcome to the Urban Revolution (2009), as well as the smart building showcase of engineering multinational conglomerate Siemens, The Crystal. The article demonstrates how the trope of urban complexity is mobilized to project the city as a generic scalable entity of creativity and energy efficiency. It becomes the basis of an infrastructural imaginary of neoliberal innovation that supports entrepreneurial and ‘smart-eco’ agendas of urban design and governance that promise – but have yet to deliver – planetary ecological amelioration.
Izvršenje na nekretninama u svjetlu propisa izvršnog, zemljišnoknjižnog i stvarnog prava u Bosni i Hercegovini
Authors: Mutapčić Hamid
Published: February 2021

Mogućnost izvršenja na izvršenikovom neupisanom pravu na nekretnini uslovljena je pravilnim razumijevanjem nove zakonske definicije načela upisa. Neusaglašenost odredaba materijalnog prava u pogledu dejstva uknjižbe i trenutka u kojem se stiče pravo na nekretnini dovodi do različitih pravnih shvatanja u pravnoj teoriji, što može generirati pojavu neujednačene prakse u primjeni prava. U radu je izvršena analiza odredaba izvršnog, a u vezi s odredbama zemljišnoknjižnog i stvarnog prava, koje predviđaju mogućnost izvršenja na nekretnini koja je u samostalnom posjedu izvršenika, odnosno na nekretnini na kojoj izvršenik ima utvrđeno vanknjižno pravo vlasništva.
Ogled o odnosu demokratije i federalizma: teorija, ustavne slike i socio-političke stvarnosti
Authors: Trlin Davor
Published: February 2021

Autor se u radu bavi analizom teorijskih osnova odnosa dva oblika države, te ispitivanjem ustavnih sistema selektovanih izvedbenih oblika federalizma (Sjedinjene Američke Države, evropskokontinentalni pravni krug i Evropska unija). Cilj rada je pokušati izvesti neke poopćive zaključke te prikazati kako su najprogresivniji izvedbeni oblici federalizma regulirali demokratiju u svojim najvišim pravno-političkim aktima, a posebno neposredno učešće građana u donošenju odluka. Poseban cilj rada je da se kompariraju rješenja iz drugih federacija sa stanjem u Bosni i Hercegovini, a posebno nas zanimaju Švicarska i Belgija, za koje se smatra da imaju elemente konsocijacijske demokratije u svom ustavnom sistemu. Bosna i Hercegovina je idealni tip konsocijacijske demokratije. Na državnom nivou BiH nema mogućnosti za neposrednu demokratiju. Pokušaćemo pronaći sličnu ustavnu sliku u selektovanim državama.
L' harmonisation travail-vie personnelle des gestionnaires du réseau de la santé : exploration des défis et des stratégies
Authors: Payette Benoît , Chrétien Lise
Published: February 2021

L’objectif de cet article est de proposer un cadre d’analyse des défis que doivent relever des gestionnaires du réseau de la santé lors de la réalisation d’une démarche d’harmonisation travail-vie personnelle. Les résultats s’appuient sur l’analyse qualitative d'autodiagnostics d’harmonisation travail-vie personnelle de 84 gestionnaires évoluant dans un contexte de travail sous pression. À l’aide d’une méthode d’analyse de contenu, cet article dresse un panorama détaillé des problèmes vécus et des stratégies mobilisées par des gestionnaires du réseau québécois de la santé pour résoudre certains conflits de travail-vie personnelle. À titre de contribution à la littérature existante, nous proposons une typologie de cinq types de stratégies – de gestion, affectives, de légitimation, de réduction de surcharge, et temporelles – par lesquelles des gestionnaires tentent de créer et de maintenir leur équilibre de vie. L’efficacité de ces stratégies est discutée et illustrée au moyen de cas servant de modèles, ou prototypes.
La dynamique du stress au travail est-elle transactionnelle?
Authors: Harnois Claudie , Picard Karine , Rivard Sébastien , Tremblay Jean-François , Gosselin Éric
Published: February 2021

Le modèle transactionnel du stress est l'un des modèles explicatifs les mieux connus. Par un mécanisme de double évaluation, cette perspective cognitivo-phénoménologique propose que l'état de stress émane d'une inadéquation entre les demandes contextuelles et les ressources personnelles. Peu de validations intégrales de ce modèle ont été effectuées jusqu’à maintenant. Cette étude propose une vérification de l’ensemble de la dynamique transactionnelle du stress en contexte professionnel au moyen d’une étude transversale auprès de 420 enseignants. L'étude cherche à vérifier la séquence sous-jacente au modèle transactionnel ainsi que divers effets médiateurs/modérateurs issus de l'intervention de certaines caractéristiques individuelles. Les résultats des analyses statistiques permettent globalement de considérer que la perspective transactionnelle est une façon efficace de conceptualiser le stress au travail en milieu scolaire.
Vietnamese Studies in Germany
Authors: Engelbert Thomas
Published: February 2021

From modest beginnings in the 1950s and 1960s, Vietnamese studies experienced a slow but consistent rise in Germany. In the GDR, the rise was connected first with close relations between the two communist states. Second, the area studies’ concept favored Vietnamese studies as a subject of Southeast Asian studies, rather than as a side subject of sinology as it had been before. In both parts of Germany, the interest in Vietnam has grown, especially after its reunification in 1975. Since 1990, at least one place is continuing to teach the subject in the framework of the Southeast Asian Languages and Cultures Program. In this way, one of the two professorships could be preserved.
AI at banking infrastructure
Authors:   State Higher Education Institution “Vadym Hetman Kyiv National Economic University”, S.V. Ustenko , T.V. Ostapovych ,   State Higher Education Institution “Vadym Hetman Kyiv National Economic University”
Published: February 2021

Efforts for better services are achieved by small steps such as analyzing data of the customer. What is significant for the customer should as well significant for the banking institution. Transparency and a better understand- ding of the pattern behavior of customers can be used for the good of both partners such as good relationships in the fu- ture eventually be beneficial for the customer as well as a banking institution. The responsibility of both sides is crucial to understand the accountability of customers and banking institutions. The method of identification of user messages of the banking application proposed in the article involves the use of user data for information processing, taking into account the peculiarities of the use of mobile devices and the user's dialogue with bank messages. Also, the proposed method allows you to rank messages to identify the most important messages and get the desired result by providing ef- fective recommendations in favor of each of the participants in customer interaction with the bank. The introduction of modern educational programs "Information Control Systems and Technologies", "Artificial Intelligence Systems" and "Systems Analysis" in the field of information technology, allows users and managers to interact with the bank's custo- mers sufficient information to make informed recommendations for effective management decisions. The article consi- ders the conceptual model of interaction of users and managers on interaction with users of the bank, use of technolo- gies and algorithms of artificial intelligence, machine learning processes to formalize the process of dialogue, systema- tization and ranking of messages and notifications between customers and managers. The Conceptual model of inter- action of the user of banking services with messages is presented. The article also describes the features of the dialogue between the user of banking services and the manager for the implementation of algorithms for interaction with custo- mers. The example of the city block of bank users considers and takes into account the difference in the amount of in- formation received by the bank, which must be sent during different periods of the week and take into account the amount of information to be sent, which will be significantly less and, consequently, the number of necessary services. will also be smaller. In this example, taking into account the amount of information that can be consumed during differ- rent periods of the week, the number of services that can be provided to the user will also be much smaller. The reflec- tion of such interactions in the model is an important aspect, as noted in the article.
Analysis and modification of graphic data compression algorithms
Authors:   Belarusian State University, M.K. Bouza
Published: February 2021

The article examines the algorithms for JPEG and JPEG-2000 compression of various graphic images. The main steps of the operation of both algorithms are given, their advantages and disadvantages are noted. The main differences between JPEG and JPEG-2000 are analyzed. It is noted that the JPEG-2000 algorithm allows re-moving visually unpleasant effects. This makes it possible to highlight important areas of the image and improve the quality of their compression. The features of each step of the algorithms are considered and the difficulties of their implementation are compared. The effectiveness of each algorithm is demonstrated by the example of a full-color image of the BSU emblem. The obtained compression ratios were obtained and shown in the corresponding tables using both algorithms. Compression ratios are obtained for a wide range of quality values from 1 to ten. We studied various types of images: black and white, business graphics, indexed and full color. A modified LZW-Lempel-Ziv-Welch algorithm is presented, which is applicable to compress a variety of information from text to images. The modification is based on limiting the graphic file to 256 colors. This made it possible to index the color with one byte instead of three. The efficiency of this modification grows with increasing image sizes. The modified LZW-algorithm can be adapted to any image from single-color to full-color. The prepared tests were indexed to the required number of colors in the images using the FastStone Image Viewer program. For each image, seven copies were obtained, containing 4, 8, 16, 32, 64, 128 and 256 colors, respectively. Testing results showed that the modified version of the LZW algorithm allows for an average of twice the compression ratio. However, in a class of full-color images, both algorithms showed the same results. The developed modification of the LZW algorithm can be successfully applied in the field of site design, especially in the case of so-called flat design. The comparative characteristics of the basic and modified methods are presented.
Spatial injustice in the formation of land use territories in united communities
Authors:   SO ", Popova O. L. ,   Institute for Economics and Forecasting, National Academy of Sciences of Ukraine",   26, Panasa Myrnoho, Kyiv, 01011, Ukraine
Published: February 2021

The author revealed the injustices in the territories formation of the united territorial communities (UTC) under the local self-government reform, which are manifested in different, uneven volumes of their land use and the resource basis in general for local socio-economic development. The methodological approach used by the authorities in determining the capacity of united communities in their formation (in terms of compliance with the criteria – the area and the population density), led to the fact that in rural areas with low population density they had to form large UTCs to reach specific parameters by population. The hypothesis that territorially large UTCs are capable is ambiguous: on the one hand, land tenure and land use is a resource for socio-economic development of communities, on the other – in a large area the cost of providing essential services to the population in remote villages increases together with the administrative and other costs. Paper proves that large-scale rural UTCs should become objects of the state support as the “rural areas in unfavourable conditions” under the State Strategy for Regional Development for 2021–2027. The author justifies injustices in the centralization of powers on disposal of land resources. The land decentralization as a transfer of relevant powers to UTC local governments will be finally completed, according to the Decree of the President of Ukraine “On some measures to accelerate reforms in the field of land relations” № 449 from 15.10.2020, which will contribute to orderliness in this area and filling local budgets. It is also advisable within the UTCs to give internal communities the right to dispose of their economic territory’s land resources in these communities’ interests. The paper shows discriminatory aspects of administrative reformatting of 120 voluntarily formed and functioning UTCs, according to the Government’s long-term plans for 2020: by recognizing them as insufficiently capable, they should join other communities or unite into larger UTCs.
Socio-educational activity of students in the framework of social projects
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University 32, Ostrozkogo Str., Vinnytsia, 21001, Ukraine, Sarancha I. H. , Khilya A. V. ,   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University 32, Ostrozkogo Str., Vinnytsia, 21001, Ukraine
Published: February 2021

This article focuses on the organization and implementation of social projects, programs and their importance for future professionals such as teachers, social educators, social workers, psychologists and others. Based on the experiences of the NGO “Vinnytsia City Organization for Social Development of specific categories of vulnerable youth “Parostok”, authors presented a brief methodological overview to encourage students to social and educational activities. This allowed to partially characterize the areas of interaction between public authorities, civil society institutions and higher education institutions. Also, the authors presented practical examples of cooperation between social institutions; the training of specialists in the educational and social spheres to provide services to crisis categories of the population in terms of social benefits and educational management. The aforementioned allowed to reveal the purpose of authors’ research from the scientific and pedagogical perspective; reveal the social significance of project activities; explore the main factors of successful socio-pedagogical activities in various projects; explore issues related to educational management (goals, objectives). The experience gained in the implementation of social projects and their administration provided an opportunity to present the educational potential of interaction between social institutions and higher education faculty prepare for volunteer, planning, administrative, and socio-pedagogical activities of future professionals. Authors also stressed the importance of such work from the pedagogical management viewpoint, which is also evident in the article’s conclusions and identifies areas for the further scientific development. The presented results do not cover the whole range of organizational cooperation in preparing students for socio-pedagogical activities, development and implementation of social projects and programs. However, paper outlined a wide range of opportunities for further scientific research and development by various specialists in education and human resourcing. It can be used by a wide range of professionals who plan to join the project activities.
Socio-economic attitudes of the Ukrainian population at the end of 2020
Authors:   SO ", Balakireva O. M. ,   Institute for Economics and Forecasting, National Academy of Sciences of Ukraine",   26, Panasa Myrnoho Str., Kyiv, 01011, Ukraine, Dmytruk D. A. ,   SO "Institute for Economics and Forecasting, National Academy of Sciences of Ukraine" 26, Panasa Myrnoho Str., Kyiv, 01011, Ukraine
Published: February 2021

The national survey data is presented on the self-assessment of financial situation, delay or non-payment of wages, pensions, shadow incomes, subsistence wage, indices of socio-economic assessments and expectations of the Ukrainian population, the level of trust in the President of Ukraine, the Verkhovna Rada of Ukraine and the Cabinet of Ministers, as well as on the general political situation in Ukraine.
Digest of U-Report surveys: 4th quarter of 2020 (youth career development, creative potential of youth, healthy lifestyle)
Authors:   NGO “Ukrainian Institute for Social Research after Olexander Yaremenko” 26, Panasa Myrnoho Str., Кyiv, 01011, Ukraine, Nesterenko Ye. O. , Liudohovska K. V. ,   NGO “Ukrainian Institute for Social Research after Olexander Yaremenko” 26, Panasa Myrnoho Str., Кyiv, 01011, Ukraine
Published: February 2021

Paper presents the results of the innovative youth project U-Report. Report for October – December 2020: job satisfaction; factors influencing the choice of profession by young people; career development skills; creative leisure; opportunities for the realization of the creative potential of adolescents; the healthy lifestyle of young people.
Development and implementation in medical practice of new information technologies and metrics for the analysis of subtle changes in the electromagnetic field of the human heart
Authors:   Glushkov Institute of Cybernetics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Chaikovsky Illya A. , Primin Mykhailo A. ,   Glushkov Institute of Cybernetics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Kazmirchuk Anatolii P. ,   National Military Medical Clinical Center "Main Military Clinical Hospital"
Published: February 2021

The article details the concept of clinical information technology (IT), i.e. a set of methods and software and hardware combined into a technological chain, the product of which is an automated diagnostic report, prognostic report or recommendation on patient management tactics. There are several examples of innovative information technologies and metrics implemented by the authors in Ukraine and abroad, designed to register and evaluate subtle changes in the electromagnetic field of the heart for early diagnosis of the most common and dangerous heart diseases, especially coronary heart disease. It is shown that new metrics of analysis of spatial structure of 2D and 3D magnetocardiographic maps of current density distribution allow to diagnose with high accuracy various forms of myocardial ischemia. The new method of the electrocardiogram scaling is used in various areas of clinical medicine, sports medicine, occupational medicine, as well as in large-scale population studies.
Ukraine as a civilizational subject: a new method-ology for human development and society (review of monograph by S. Pyrozhkov, N. Khamitov Ukraine as a civilizational subject: from potencies to a new worldview and human existence)
Authors:   National Academy of Educational Sciences of Ukraine, Kyiv, Ukraine, Kremen Vasyl H.
Published: February 2021

The monograph by S. Pyrozhkov, N. Khamitov “Ukraine as a civilizational subject: from potencies to a new worldview and human existence” (Kyiv, Naukova Dumka, 2020) is devoted to understanding the civilizational subjectivity of Ukraine: a state of development when our country decides its civilized destiny, chooses identity and partners. The authors pose and solve the problem of inventing an effective methodology for understanding the country as a subject of history and geopolitics, propose the development of a humanistic civilization project that would contribute to a decent human self-realization. The paper substantiates the need for the formation of a new security system in a hybrid war, as well as the Euro-Atlantic vector as a catalyst for the subjectivity of Ukraine.
Complex stress state of materials and structural elements and strength criteria: the scientific business card of Academician A.O. Lebedev
Authors:   Pisarenko Institute for Problems of Strength of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Matveev Valentin V. , Zinkovskii Anatoliy P. ,   Pisarenko Institute for Problems of Strength of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Published: February 2021

On February 1, the scientific community celebrates the 90th anniversary of a prominent Ukrainian scientist in the field of deformable solid mechanics, laureate of the USSR State Prize (1982), the State Prize of Ukraine in Science and Technology (1997), Honored Worker of Science and Technology of Ukraine (2001), laureate of S.P. Tymoshenko (2004) and G.S. Pysarenko (2011) Prizes of the NAS of Ukraine, Doctor of Technical Sciences (1972), Professor (1976), Academician of the NAS of Ukraine (1988) Anatoliy O. Lebedev.
An outstanding organizer of academic legal science and higher legal education in Ukraine is our con- temporary (to the 85th anniversary of Academician of NAS of Ukraine Yu.S. Shemshuchenko)
Authors:   Koretsky Institute of State and Law of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Skrypniuk Olexandr V.
Published: February 2021

December 14, 2020, marks the 85th anniversary of an outstanding Ukrainian scientist in the field of jurisprudence and political science, laureate of the State Prize of Ukraine in the Field of Science and Technology (2004), Honored Worker of Science and Technology of Ukraine (1995), laureate of the NAS of Ukraine Prizes named after D.Z. Manuilsky (1991) and M.P. Vasylenko (1998), winner of the Yaroslav the Wise Prize of the National Academy of Law Sciences of Ukraine and the Yaroslav the Wise National Law University (2014), Director of the V.M. Koretsky Institute of State and Law of the NAS of Ukraine (since 1988), Honorary Rector of Kyiv University of Law of NAS of Ukraine (2006), Doctor of Law (1979), Professor (1985), Academician of NAS of Ukraine (1992), Academician of National Academy of Law Sciences of Ukraine (1993) Yu.S. Shemshuchenko.
Analisa Faktor yang Mempengaruhi Kondisi Kesehatan Menggunakan Algoritma Frequent Pattern Growth
Authors: Evadini Sukma , Nazir Alwis , Pizaini Yusra
Published: February 2021

Health is an important factor in human life that have to be guarded, both physically and mentally. This study aimed to analyze the factors that affect health condition using medical check up data. Factors analyzed were consuming alcohol, smoking, exercise, age and gender. The method was the association rule using FPGrowth. The result of this study was factors that affect the health condition is alcohol, exercise and age. This result evidenced by the rules A3→K3, which means that if a person consumes more alcohol than 4 days/week with the amount of alcohol is less than 180ml/day, then health condition was poor with 11% support and 67% confidence. E1→K3, which means that if one rarely exercise then health condition was poor with 24% support and 99% confidence. G2→K3, which means that if a person in middle age group, then the condition of health was poor with 24% support and 99% confidence.
Rancang Bangun Sistem Informasi Pengamanan Lingkungan Kampus Berbasis Mobile
Authors: Aninditho Garrin Alif , Arham Zainul , Khudzaeva Eva
Published: February 2021

Universitas Indonesia Depok merupakan kampus yang luas dengan atmosfer green campus yang dipenuhi area hijau dengan wujud hutan kota. UI Depok sering digunakan sebagai jalan lintas yang menghubungkan beberapa wilayah, sehingga memudahkan orang lain tanpa kepentingan untuk memasuki lingkungan kampus dengan tujuan tertentu. Hal ini menyebabkan lingkungan kampus dirasa kurang aman, yang dibuktikan dengan angka kasus kriminalitas yang cukup tinggi. Korban yang mengalami kasus kriminalitas masih harus mencari petugas atau datang ke kantor UPT PLK (Unit Pengelola Teknis Pengamanan Lingkungan Kampus) untuk melaporkan kejadian demi mendapatkan penanganan. Petugas UPT PLK tidak memiliki informasi mengenai lokasi dimana kejadian kriminalitas terjadi dalam bentuk peta serta tanpa bantuan petunjuk arah menuju lokasi tersebut. Selain itu dalam pelaksanaanya, pencatatan pelaporan mengenai kasus kriminalitas masih bersifat manual dalam bentuk kertas, sehingga beresiko mengalami penumpukan dan kehilangan data. Oleh karena itu tujuan dari penelitian ini adalah menghasilkan sistem informasi pengamanan lingkungan kampus yang mampu menyelesaikan masalah-masalah tersebut. Metode pengembangan sistem yang digunakan dalam penelitian ini adalah RAD (Rapid Application Development), serta perancangan sistem dengan menggunakan tools UML (Unified Modeling Language). Tahap pengkodean dilakukan dengan menggunakan bahasa pemrograman PHP (framework Laravel 5.4) dan JAVA, MySQL sebagai database, dan Google Maps API sebagai Map Server. Hasil akhir dari penelitian ini adalah sebuah Sistem Informasi Pengamanan Lingkungan Kampus berbasis Mobile yang dapat digunakan dalam meminta pertolongan demi mendapatkan penanganan segera di lingkungan kampus Universitas Indonesia Depok berupa sinyal SOS (Save Our Souls) dengan memanfaatkan teknologi LBS (Location Based Services) pada platform Android, yang menyediakan petunjuk arah menuju lokasi kejadian, serta memberikan otomatisasi dalam pengelolaan kasus kriminalitas dalam bentuk digital.
Sistem Informasi Disposisi Surat Berbasis Android
Authors: Rahmawati Diajeng , Kumaladewi Nia , Sugiarti Yuni
Published: February 2021

Sesuai dengan peraturan Menteri Negara Pendayagunaan Aparatur Negara dan Reformasi Birokrasi Republik Indonesia Nomor 6 Tahun 2011 tentang Pedoman Umum Tata Naskah Dinas Elektronik di lingkungan instansi pemerintah, pemerintah menghimbau pada semua instansi pemerintah untuk menyusun tata naskah dinas elektronik (sistem informasi administrasi persuratan) masing-masing, yang mengacu pada panduan dalam peraturan tersebut. Pada proses tata naskah dinas yang dilaksanakan oleh pusat pembinaan kompetesi dan pelatihan konstruksi (Pusbin KPK) ialah disposisi persuratan. Disposisi merupakan salah satu media pemberitahuan informasi yang penting bagi suatu instansi pemerintahan ini. Permasalahan disposisi yang terjadi pada Pusbin KPK adalah proses disposisi yang membutuhkan waktu yang lama. Penelitian ini bertujuan untuk memudahkan staf untuk mengelola data persuratan yang ada pada Pusat Pembinaan Kompetensi dan Pelatihan Konstruksi. Rancang Bangun Sistem Informasi Disposisi Surat ini menggunakan metode RAD (Rapid Application Development) dengan Tools UML (Unified Modeling Language). Dari hasil penelitian sistem disposisi surat berbasis android ini dapat membantu dalam pengelolaan, penyimpanan serta pencarian arsip surat pada Pusat Pembinaan Kompetensi dan Pelatihan Konstruksi.
Enterprise Architecture Menggunakan TOGAF Architecture Development Method 9.1
Authors: Nurmiaty Evy , Zulfiandri Zulfiandri , Syafi’i Abdul Mughni Ashirotu
Published: February 2021

LEMIGAS merupakan lembaga pemerintahan yang bergerak sebagai badan penelitian dan pengembangan yang berfokus pada sektor teknologi minyak dan gas bumi milik kementerian energi dan sumber daya mineral. Saat ini penerapan SI/TI di lingkungan LEMIGAS belum optimal mengacu kepada sistem yang belum terintegrasi sehingga pertukaran data dan informasi tidak efektif, investasi SI/TI yang dilakukan juga belum memberi return yang baik, proses pengadaan setiap tahunnya secara konsisten tidak optimal, dan beberapa indikator kinerja ditemukan tidak memenuhi targetnya. Oleh sebab itu, diperlukan adanya perencanaan enterprise architecture pada LEMIGAS yang bertujuan untuk merumuskan prinsip dan dasar-dasar LEMIGAS agar sesuai dengan arah tujuannya sehingga menghasilkan proses bisnis yang sehat, sistem yang dapat mendukung kegiatan operasional serta infrastruktur yang mampu menunjang sistem tersebut dapat berjalan baik. Perencanaan enterprise architecture ini dibuat menggunakan TOGAF (The Open Group of Architecture Framework) versi 9.1 dengan metode ADM (Architecture Development Method). Perencanaan enterprise architecture ini akan menghasilkan diantaranya peta kegiatan utama dan pendukung LEMIGAS, stakeholder, fokusnya, tujuan bisnisnya dan prinsip dasarnya, blueprint target arsitektur bisnis, arsitektur sistem informasi, arsitektur teknologi, analisis gap, serta roadmap implementasi aplikasi.
The Influence of Corporate Communication Strategy and Customer Value Creation Toward Creation of Reputation (Case Study)
Authors: Syaifuddin Syaifuddin
Published: February 2021

The objectives of this research are to know and to analyze corporate communication strategy, customer value creation, creation of corporate reputation and the influence of corporate communication strategy and customer value creation toward creation of corporate reputation. This research is descriptive and verificative with descriptive survey and explanatory with stratified random sampling. The amount of sample is 55 respondents. Data collection techniques are library data, observation, and questioner. Analysis data used is path analysis. Research results show that the corporate communication strategy and customer value creation influence the creation of reputation Len Industri Group is 53.7% simultaneously. The influence of corporate communication strategy to the creation of reputation is at 47.2% partially whereas the customer value creation does not significantly influence the creation of reputation is 5.1%.
SISTEM PENGINGAT PADA GUDANG PT. ALFA BEAUTY COSMETICA MENGGUNAKAN SMS GATEWAY
Authors: Warisman Arey Nur , Salamah Umniy , Jumaryadi Yuwan
Published: February 2021

The development of technology is very important for humans, especially in the field of storage of goods that become a useful and important thing in the world of warehousing. In this study the authors take a case study at PT. Alfa Beauty Cosmetica  who still uses warehouse reports manually. This study aims to facilitate the work of employees of PT. Alfa Beauty Cosmetica. Employees can store in-app items consisting of goods unique code, item name, recording location of goods and recording transactions of goods. Message reminder simulation is if stock will run out using web based Gateway SMS. With stock reminder messages, employees are quicker at updating inventory. This application is expected to accelerate employee work.
IMPLEMENTASI METODE FUZZY TIME SERIES DENGAN MODEL ALGORITMA CHEN UNTUK MEMPREDIKSI HARGA EMAS
Authors: Nababan Darsono , Alexander Eric
Published: February 2021

Gold is one of the people's preferred forms of investment and is considered the safest (save -heaven). Gold risk which is considered small is the main attraction because in general Indonesian people are not yet familiar with capital market investments such as stocks and mutual funds. But the price of gold is very volatile as for the factors that affect the fluctuations of gold are consumption demand, volatility and market uncertainty, protection of low-interest rates, and the US dollar. Predicting the movement of the gold price and knowing where the direction of the exchange rate moves and determining the price of gold up or down cannot be done accurately and consistently. For this reason, in reducing the risk of loss, an application is needed to predict gold prices using the Fuzzy Time Series Chen algorithm using MATLAB software. In this study to obtain prediction results and comparison charts using actual data and prediction data for the 2015-2017 gold price. From the calculation results obtained by the prediction results with the Fuzzy Time Series method with the Chen algorithm where the average difference between the actual data and prediction data is not more than Rp. 2,850, - where predictions using the Fuzzy Time Series method Chen's algorithm is sufficient to use 1 data to predict the second data which makes this method accurate in predicting the price of gold.
BULGARIAN AND MACEDONIAN STUDENTS’ EXPERIENCE IN VOLUNTEERING
AND OPPORTUNITIES FOR ITS PROMOTION
Authors: Hristova Petya , Popeska Bilyana
Published: February 2021

The article highlights the importance of volunteering as a way to create more democratic, caring and responsible society. It overviews the possibilities and personal benefits offered by this activity nowadays. It also emphasizes the significance of volunteering in sport events as a way for introducing the importance of physical exercise for humans’ health. It shows the results from a study aimed at exploring the experience in volunteering of university’ students in Bulgaria and Macedonia as well as their motives to stay or become a volunteer. The results show that young people do not have much experience in this field and that they are not very well educated about all possibilities that volunteering offers today. The authors give some recommendations for the promotion of volunteering among young people.
Winder, B., Blagden, N., Hocken, K., Swaby, H., Lievesley, R., & Banyard, P. (eds) (2019). Sexual crime, religion and spirituality.
Authors: Heslop Andrew
Published: February 2021

Winder, B., Blagden, N., Hocken, K., Swaby, H., Lievesley, R., & Banyard, P. (eds) (2019). Sexual crime, religion and spirituality. Cham, Switzerland: Palgrave Macmillan. 232 pp. (ebook). ISBN 978-3-030-26040-8. https:// doi.org/10.1007/978-3-030-26040-8
Gobierno y órdenes sociales en «Quién es el hombre. Un espíritu en el tiempo»
Authors: García-Muñoz José-Alpiniano
Published: February 2021

Quién es el hombre. Un espíritu en el tiempo es un libro que muestra de qué modo están involucrados los órdenes sociales en la filosofía poliana. En esta obra Leonardo Polo presenta explícitamente su pensamiento político en dos fases. En la primera diagnostica sobre la situación política actual. En la segunda propone un modelo de gobierno que empodera a la sociedad civil, y un orden político-económico fundamentado en el derecho al libre desarrollo de la personalidad.