bluuebunny/crossref_metadata_2025 huggingface dataset:
AAV Production in HEK293T Cells v1
Authors: The Nonprofit Plasmid Repository Addgene
Published: November 2019

This protocol is used for AAV production in HEK293T cells. To see the full abstract and additional resources, visit the Addgene protocol page. Sample Data
iconHi-C Protocol (ver. 1.0) v1
Authors: Kadota Mitsutaka
Published: November 2019

Hi-C, a derivative of chromosome conformation capture (3C) targeting the whole genome, was originally developed as a means for characterizing chromatin conformation and is recently employed widely in scaffolding nucleotide sequences obtained by de novo genome sequencing. To gain insights into the best practice of Hi-C scaffolding, we performed a multifaceted methodological comparison and optimized various factors during sample preparation, sequencing, and computation. As a result, we have identified some key factors for efficient Hi-C data acquisition, including preparation of tissues, library preparation conditions, and quality controls of prepared samples. By incorporating those optimal conditions revealed by our experience, we release this customized protocol designated the ‘inexpensive and controllable Hi-C (iconHi-C) protocol’.
Lentivirus Production v1
Authors: The Nonprofit Plasmid Repository Addgene
Published: November 2019

This protocol is for Lentivirus production. To see the full abstract and additional resources, visit the Addgene protocol page. Sample Data
Vencidos pela 'fama' do não visto César: os boatos e a invasão de César à Itália em 49 a.C.
Authors: Belchior Ygor Klain
Published: November 2019

Este artigo tem como objetivo estudar o papel dos boatos durante o avanço de César sobre a Itália, no contexto das guerras civis contra Pompeu (49-48 a.C.). Como sabemos, César, ao cruzar o Rubicão, estava em desvantagem e em menor número de homens, só que mesmo assim conseguiu conquistar a Península, afugentando o seu inimigo. A nossa hipótese é que tal vitória foi facilitada pela circulação de boatos acerca da fama do general vitorioso e das suas tropas. Almejando, então, avaliar essa influência dos boatos neste contexto, estudamos as obras de Lucano, Cícero, Dião Cássio, Suetônio, Plutarco, Apiano e, é claro, as do próprio César.
'Pax' e imperialismo: da República ao Principado através das guerras civis
Authors: Cunha Macsuelber de Cássio Barros
Published: November 2019

Resenha do livro: CORNWELL, Hannah. Pax and the Politics of Peace: Republic to Principate. Oxford: Oxford University Press, 2017. 272 p.
Apolo, Hércules e Chrysas no 'De Signis', de Cícero (Verr. 2, 4, 93-96)
Authors: Beltrão Claudia
Published: November 2019

O De signis, o quarto discurso da segunda actio das Verrinas de Cícero, é uma rica fonte para o estudo das estátuas divinas e os modos de percepção, conhecimento e práticas religiosas na República tardia. O discurso de Cícero é pleno de informações sobre essas estátuas, seus lugares e gestos a elas relacionados, lidando com emoções religiosas. Em uma breve seção do De signis, pode‑se perceber o conflito entre o (mau) propretor e (bons) povos aliados materializado nas estátuas divinas de Apolo, Hércules e Chrysas. Cícero elogia as violentas respostas das populações locais contra um violento e indigno magistrado romano – como ele constrói a figura de Verres. O orador não apenas lança mão de conceitos e ideias sobre as divindades, mas, com base em crenças, temores e esperanças compartilhadas, Cícero os cria para sua audiência.
Avaliação do consumo de fósforo, potássio e alimentos ultraprocessados em pacientes com doença renal crônica
Authors: Bertani Juliana Paula Bruch , Crislei Ludvig Tuani , Giovanella Cleidi Eunice , Rufatto Conde Simara
Published: November 2019

Introdução: Pacientes com doença renal crônica em hemodiálise necessitam orientações adequadas quanto a escolha de uma alimentação equilibrada, pois a qualidade da dieta pode influenciar diretamente no curso da doença. Objetivo: Caracterizar e avaliar o consumo de alimentos processados e ultraprocessados, fósforo e potássio em relação às recomendações para pacientes com doença renal crônica em hemodiálise. Métodos: Estudo transversal e quantitativo, realizado em uma Clínica de Nefrologia, no Vale do Taquari/RS, Brasil. A amostra foi por conveniência, composta por 47 pacientes. Foi utilizado registro alimentar de três dias não consecutivos, sendo avaliado o consumo de carboidrato, proteína, lipídios, fósforo e potássio para posteriormente serem comparados aos valores preconizados para pacientes com doença renal crônica renal. Para avaliar o consumo de alimentos processados e ultraprocessados, foi avaliada a frequência dos alimentos correspondentes encontrados no registro alimentar, utilizando como recomendação o Guia Alimentar para a População Brasileira. Resultados: Constatou-se um consumo inferior significativamente ao recomendado para carboidrato e lipídio (p ≤ 0,01), significativamente superior (p ≤ 0,01) em relação às proteínas. A ingestão de potássio estava abaixo da recomendação e do fósforo dentro das recomendações. Para os alimentos processados e ultraprocessados, o consumo médio foi de 17,70% das calorias totais ingeridas. Conclusão: O consumo de carboidrato, proteína, lipídios e potássio foi inadequado, quando comparado às recomendações preconizadas para os pacientes com doença renal crônica em hemodiálise. Quanto aos alimentos processados e ultraprocessados, o percentual encontrado é preocupante, visto que a qualidade desses alimentos pode trazer prejuízos ao estado nutricional e consequentemente ao tratamento dos pacientes avaliados.
Descritores: Nefropatias; Diálise Renal; Consumo de Alimentos; Fósforo; Potássio.
Methods for Preventing Depression on Digital Platforms and in Social Media
Authors: Danina M.M. , Kiselnikova N.V. , Kuminskaya E.A. , Lavrova E.V. , Greskova P.A.
Published: November 2019

The prevalence of depression among the population estimated at 8-12%. The World Health Organization admits that the existing help system is not sufficiently successful in dealing with depression, and gives priority to online methods – accessible and anonymous. So it can be used by a large number of people and can help to overcome the problem of stigmatization of people with depression. In the article current trends in using online diagnostics tools (mobile applications and gadgets) are discussed and detection of groups with depression risk in social media digital footprints are analyzed. The prospect of research consists in studying the mechanisms and identifying specific components of programs related to the preventive effect, as well as the possibilities of using online methods to work with other mental disorders.
The role of Astana primary health care declaration for development of primary health care at postsoviet countryes
Authors: Brimkulov Nurlan N. , Nugmanova Damilya S.
Published: November 2019

The article presents the goals, principles and results of the implementation of the Almaty Declaration of the World Health Organization (WHO) on primary health care (PHC) of 1978; the background and main provisions of the Astana Declaration of WHO on PHC 2018. The article presents the stages of PHC development in the USSR, which was characterized by the widespread introduction of narrow specialists at the primary level of health care, which subsequently had certain negative consequences. In a number of post-Soviet countries, the principles of General medical practice (family medicine) were implemented in health care reform, but some provisions of the Alma-Ata Declaration were introduced with distortions. This has led to a lack of effective functioning of the PHC system, a shortage of General practitioners, especially in rural areas. The implementation of the main principles of the new Astana Declaration will be important for the effective implementation of health care reforms in all post-Soviet countries.
Podstawowe czynniki wpływające na funkcjonowanie systemu readaptacji społecznej skazanych – diagnoza i rozwój
Authors: Stasiorowski Sławomir
Published: November 2019

Zmieniający się obraz polityki karnej Państwa i wiodąca w niej rola kar alternatywnych wobec kary pozbawienia wolności, tj. kary grzywny oraz ograniczenia wolności, przy jednoczesnym ograniczeniu funkcji wychowawczo-resocjalizacyjnej kuratora sądowego, prowadzą niepostrzeżenie do ewolucji jego zadań. Jednocześnie rosną oczekiwania w zakresie podniesienia skuteczności działań mających na celu pomoc skazanemu opuszczającemu jednostkę penitencjarną w społecznej readaptacji, która zazwyczaj postrzegana jest przez pryzmat świadczeń i usług o charakterze wspierającym, materialnym lub administracyjnym. Dostrzegając te zjawiska, autor artykułu prezentuje systemowe podejście do readaptacji społecznej skazanych oparte na nowym, hybrydalnym modelu przygotowania skazanego do życia na wolności. System opierający się na wzajemnej wiedzy o sobie jego uczestników jest nieskomplikowany, zrozumiały i winien być powszechny. Centralną w nim rolę upatruje w instytucji kuratora sądowego, którego zadania nie zostały precyzyjnie określone przepisami prawa. Jednocześnie wskazano na możliwości, jakie daje obserwacja funkcjonującego systemu pod względem jego skuteczności, która może być wykorzystywana w prognozie powrotności do przestępstwa sprawców objętych jego oddziaływaniami.
Utilization of Hydrolysis Lignin in Compositions Soil-Cements
Authors: Konovalova N.A. , Dabizha O.N. , Pankov P.P. , Rush E.A.
Published: November 2019

The article investigated the compositions of road-building materials containing screenings of rock crushing, Portland cement, hydrolyzed lignin, modified by the stabilizing additive “Element”. The road-building compositions containing screenings of rock crushing, Portland cement, hydrolyzed lignin modified with the stabilizing additive "Element" were investigated. The optimal content of raw materials has been established, which allows to obtain soil-cements with a strength mark of at least M 60 - M 75. Using a model experiment, it was shown that the stabilizing additive “Element” is active and can interact with each of component of the raw materials. Using the methods of scanning electron microscopy, infrared spectroscopy, X-ray phase analysis, it has been experimentally shown that the processes of hydration, carbonization and increasing the connectivity of orthosilicate anions play a significant role in the structure formation of soil-cements.
The Use of Polymer and Glass Waste to Obtain a Self-Glazing Facing Ceramic
Authors: Vitkalova I.A. , Torlova A.S. , Pikalov E.S. , Selivanov O.G.
Published: November 2019

The results of the development of a composition of a mixture based on low-plastic clay, which includes the waste of unplasticized polyvinyl chloride as some combustible additives, the cullet of common window glass as a flux-hardening additive and additionally containing boric acid as a flux, are presented. This composition allows you to comprehensively dispose of two types of consumption waste with obtaining high quality ceramic facing materials. In this case, waste of unplasticized polyvinyl chloride of any degree of purity and destruction can be used. Practical use of the developed composition allows you to expand the raw material base for the production of building ceramics, reduce the cost of products and reduce the environmental load from waste.
Álvaro Siza and Carlos Castanheira’s China Design Museum: Form, Contemporary City and Design Method
Authors: de Araújo Miguel Borges
Published: November 2019

Portuguese architects, Álvaro Siza and Carlos Castanheira’s China Design Museum of the China Academy of Art in Hangzhou (2012-2018) calls for a problematization of the theme of the “boundary” at different levels. In this essay the project is compared with other relevant works in regards to form, the contemporary city and design method. Formed by two bars and a partly sunken volume enclosing a triangular courtyard, the building is immediately reminiscent of other L and U plans by Siza that question private/public and interior/exterior relationships. After Rem Koolhaas published “The Generic City” in 1994, the Chinese city became the epitome of the contemporary city. Since Siza’s architecture has been discussed in terms of its continuity with the city and tradition, the project of the China Design Museum raises the question: How does Siza work in the Chinese city? Siza and Castanheira’s building is at the same time part of a large campus planned by the well-known local architects Wang Shu and Lu Wenyu/Amateur Architecture, whose experimental approach to drawing and craft skills suggests yet another set of comparisons. To sum up, Siza and Castanheira avoid easy solutions: the siting and massing, scale, spatial organization and material expression of the China Design Museum provide a measure between realities – open/closed, traditional/contemporary, local/universal – that ﬁrst appeared incommensurable.
Globalisation, National Identity and the Transformation and Renovation of Museums in France and Mainland China
Authors: Jiang Yi
Published: November 2019

In the neoliberal era, to attract more visitors, museums serve not only as cultural landmarks but also as commodities. The new role leads to a transnational and consumer-oriented subsequent form of museums. Many private museums and royal palaces are renovated into publicly accessible consumer-driven architecture. Such a transformation sometimes employs globalised identities, involving collaborative architectural practice in balanced cultural exchanges of ideas. However, since the museums are national projects, they are guided by governments more or less different agendas. So as to understand the role these governments play with, comparisons between two national landmark museums - the Louvre Pyramid in Paris and the Northern part of the Palace Museum in Beijing - will be made here, according to their extension and renovation. The paper analyses similarities in museum situations and it investigates different renovation strategies to fulﬁlling the respective transformation. Moreover, it discusses causes and effects between the functions, political situations and global practices, associated with ‘governmentality’, referring to the economics and politics in the 1980s’ France and the 21
‘Global modernity’ in China and France: Flattening boundaries between Foreign Brandscapes & Regional Urban Heritage
Authors: Troiani Igea
Published: November 2019

This paper studies transnational architecture and ‘global modernity’ through the reading of two photographs of foreign, iconic buildings in China and France. The ﬁrst photograph by Hufton + Crow (2012) is of the Galaxy SOHO in Beijing by the Iraqi-born, British architect, Zaha Hadid Architect (ZHA) in collaboration with the state-ownedChineseBIAD(BeijingInstituteofArchitectureandDesign).Thelandmark, futurist ZHA building looks to have gobbled up the local urban heritage around it. The second photograph by Marc Petitjean taken in 1975 is of the Pompidou Centre in Paris under-construction and was designed by Richard Rogers and Renzo Piano with Gianfranco Franchini. In front of the Pompidou Centre is Gordon Matta-Clark’s Conical Intersect (1975) contained within a row of soon-to-be-demolished 17th century townhouses. Both the Galaxy SOHO and the Centre Pompidou are examples of transnational architecture where foreign architects crossing new global market frontiers, design landmark buildings at the expense of local heritage. They show how the rise in image culture tied to capitalism–through global branding and brand scapes – and promoted by ‘governmentality’ nurtures a culture of producing and consuming foreign architecture to redeﬁne the image of nation state. The paper discusses how globalisation ‘ﬂattens’ regionalism for modernisation. Foreign architects working on transnational architecture and their clients have an ethical responsibility to resist ‘cultural [architectural] imperialism’ (including the visual allure of the West as the alpha culture) and should instead engage deeply with regional and domestic urban values, typologies, scales and traditions to be critical of global capitalism.
Collective Form for Post-Developmental Inner-city Regeneration
Authors: Shinohara Hiroyuki , Yiu Melody
Published: November 2019

The strong and rapid urban growth of China in the past decades was largely realised through territorial expansion and essentially building cities from the ground up, a condition known as a ‘developmental city’. Many expanding Chinese cities are developmental in character with imported types in vast quantity that are becoming the new dominant types. As outward expansion began to decline in recent years, the focus of development is returning to the city centre,with the risk of large-scaleerasure of existing urban fabric along with its history and social life. This paper explores the possibilities for inner-city regeneration through evaluation of current architecture types in the urbanised Chinese city centre of Ningbo, and the potential to engage in the developmental future. Typology is utilised as a tool of investigation to reveal the evolution of the idea of the city over time.Theaimistopoint towards an urban vision of the common good with a new collective form, which can then respond to the inevitable developmental forces through a theoretical position for regeneration rooted in urban social life.
Coral Stone Architecture, Chinese Porcelain, and Indian Ocean Artifacts along the Swahili Coast: Cross-Cultural Dynamics in Medieval East Africa
Authors: Schulz Vera-Simone
Published: November 2019

While the use of Chinese porcelain dishes in the stone towns along the Swahili coast has recently found much attention in art historical scholarship regarding the eighteenth to early twentieth centuries, the pre-history of these dynamics in the medieval period has up to now only been fully considered in other ﬁelds such as archaeology and anthropology. This paper sheds new light on the interrelations between the built environment and material culture in coastal East Africa from an art historical perspective, focusing on premodern Indian Ocean trajectories, the role of Chinese porcelain bowls that were immured into Swahili coral stone buildings, and on architecture across boundaries in a medieval world characterized by far-reaching transcultural entanglements and connectivity. It will show how Chinese porcelain bowls in premodern Swahili architecture linked the stone towns along the coast with other sites both inland and across the Indian Ocean and beyond, and how these dynamics were shaped by complex intersections between short-distance and long-distance-relationships and negotiations between the local and the global along the Swahili coast and beyond.
Interactive Architecture-Interdisciplinary Design Pedagogy in Shenzhen University
Authors: . Yifei Li
Published: November 2019

Interactive architecture is deemed as a real-time narrative medium, able to reconnect and renew the relationships between participants (users) and the surroundings to help the explore the irown motivations,inspirations decisions,and outcomes.The sensor based, human-computer (machine) integrated architecture can transform and uplift people’s daily life in entirely new ways, by strategically unlocking the potentials that technological innovations bring. This paper intends to provide a platform for further research and experimentation in the realm of interactive architecture, to encourage rethinking of the relationship between human desires and responsive space (physical or intangible) through a brief introduction to interactive architecture, and to explain the original interdisciplinary teaching methods utilized in the thesis project. By reviewing conceptual and practical cases and related theories, the readers can have a primary understanding of the particular subject and may also change their way of thinking and doing architecture. As interactive architecture is still in its beginning stage, many explorations and related methodologies need to be put in a theoretical framework. Therefore, the author of this paper strongly suggests formulating a comprehensive framework in order to guide the future generation of architects for sustainable urban development.
A Study of Sustainable Social Housing Community Design in Britain and China
Authors: . Ke Liu , Leng Jiawei
Published: November 2019

BritainandChinahaveexperiencedperiodsofrapidpopulationgrowthandinadequate housing construction. Social housing is a form of housing tenure easing the housing pressure. It solves residential demands of different living patterns in middle to low-income groups. The sustainable strategy lies in three aspects:1. Making the utmost use of the local natural environment;2. Providing reasonable public spaceandsuitabletrafﬁc to revitalize community awareness; and 3. The holistic design of multiple dwelling units for different people and long-term needs. This paper shows two projects – Park Hill in Shefﬁeld, UK and Longnan Garden in Shanghai – as precedents of how to design social housing with sustainable approaches by following the local natural characteristics,by respecting traditions and the different demands of residents and the long-term housing usage. UP TO HERE Compared with China’s 20-year social housing development, that in Britain has a long history and presents complicated multiplicities, could provide signiﬁcant references. This paper shows that such communities could be design in steps: using the organic gallery apartment building layout, the special corridor system connecting the public function to neighborhoods, SI House theories optimizing the hostile design of dwelling units and components. During the design, the local nature and tradition should be respected. Speciﬁcally, the Park Hill is built up along the sloping ﬁeld, four types of apartment units are based on the traditional terraced house, designed holistically for different families; the deck, which is called “street in the sky”, is not only the trafﬁc but also the active place promoting public and neighborhoods relationships; the renovation design retains the former structure and makesthemaximizationofindoorﬂexibility.LongnanGardenissurroundedbyexisting resident districts; the organic planning based on the traditional courtyards ensures the enough sunlight and river views in the community; the community environment is improved by the courtyards,which include the ground are and roof gardens;elevated corridors run through courtyards connecting common rooms on the second ﬂoor; the 7.6-meter-heightskeletonisinnovatedfromSIhousingandtheexperienceofEuropean social housing. The paper summarizes the development tendency of social housing and provides reference for future.
Economía naranja: una opción de emprendimiento para Colombia de la mano de las instituciones de educación superior
Authors: Rodríguez Sánchez María Victoria , López López Mildre Karola
Published: November 2019

Los análisis del ecosistema emprendedor colombiano han identificado oportunidades alrededor de la economía naranja. Adicionalmente, su articulación con la educación superior tiene un gran potencial para contribuir en la formación de profesionales generadores de empleo, que contribuyan al desarrollo y bienestar de poblaciones vulnerables. El artículo presenta los primeros resultados de una investigación orientada a diseñar un modelo de internacionalización de economía naranja entre dos ciudades latinoamericanas: Bogotá (Colombia) y Zacatecas (México). Para ello, explora diferentes vínculos entre el emprendimiento y la academia, así como la reciente incorporación de la economía naranja, no solo como una alternativa de generación de ingresos, sino que añade un componente de creatividad.
Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon
Authors: TANIK Veysel Ozan , ERKEN PAMUKÇU Hilal
Published: November 2019

Amaç: Hastaların nütrisyonel
durumu ve mitral anüler kalsifikasyon (MAK) arasında ilişki daha önce herhangi
bir şekilde ortaya konulamamıştır. Daha önceki çalışmalarda prognostik nütrisyonel
indeksinin (PNİ) kolorektal kanserli hastalardaoperasyon sonrası septik
komplikasyonlar ve ST yükselmeli miyokart enfarktüsü gibi birçok hastalıkta
prognostik öneme sahip olduğu gösterilmiştir. Bu çalışmanın amacı PNİ ile MAK
varlığı arasındaki ilişkiyi ortaya koymaktır.Gereç ve Yöntemler: Bu retrospektif çalışmaya
ekokardiyografi laboratuvarına başvuran 398 hasta dahil edildi. MAK saptanan
310 hasta ile çalışma grubu,MAK saptanmayan 88 kişi ile kontrol grubu
oluşturuldu. Kontrol grubuna; yaş,cinsiyet,hipertansiyon ve diyabetesmellitus
varlığı gibi demografik özellikler açısından, MAK (+) grupla benzer özellikler
taşıyan hastalar dahil edildi. Laboratuvar parametreleri kaydedildi ve PNİ
değerleri hesaplandı.Bulgular: Gruplar
arasında ortalama yaş, hipertansiyon ve diyabet varlığı açısından fark mevcut
değildi. Serum albümin düzeyleri MAK (+) grupta kontrol grubuna göre
istatistiki olarak anlamlı olacak şekilde daha düşük seviyelerde saptandı (3,76±0,57;
4,12 ±0,31,p<0,001). Lenfosit sayısı MAK (+) grupta kontrol grubuna göre
sınırda düşük saptandı (1,86±0,63; 2,02 ±0,66,p =0,05)Prognostik nütrisyonel
indeks, mitral anulus kalsifikasyonu saptanan hasta grubunda kontrol grubuna
göre anlamlı olarak düşük saptandı (38,5±5,8 ; 42,2±3.1 ,p <0,001).
Prognostik nütrisyonel düzeyi mitral anulus kalsifikasyonun bulunması açısından
istatiksel olarak anlamlı ve güçlü, bağımsız bir risk faktörü olarak saptandı.

Sonuç: Çalışmamız sonuç olarak MAK
varlığı ile PNİ birbiriyle ilişkili bulmuştur. MAK pozitifliği ile düşük
seviyedeki PNİ değeri istatistiksel olarak anlamlı bir şekilde ilişkili
bulunmuştur.
Köpek ısırığı sonrası Proteus penneri'ye bağlı yara infeksiyonu gelişen olgu
Authors: ÖZSOY Metin , ŞENOL Selin , CESUR Salih , SEVİM Şükran , KINIKLI Sami , GÜL Sultan
Published: November 2019

Proteus penneri (P.penneri)
invaziv infeksiyon hastalalıklarına neden olabilen, nadir görülen bir Gram
negatif basildir. P.penneri  üriner sistem infeksiyonu, yara infeksiyonu,
sepsis gibi klinik tablolara neden olabilir. Bu yazıda , köpek ısırığı
sonrasında P.penneri'ye bağlı sağ
kolunda yara infeksiyonu ve pürülan akıntı gelişen, amoksisilin-klavunat
tedavisine yanıt vermeyen 57 yaşında bir kadın olgu sunuldu. Hastaya
antibiyogram sonucuna göre piperasilin-tazobaktam tedavisi 3x4.5 gr dozda
intravenöz (i.v.) yolla başlandı, tedavi 7 gün süreyle uygulandı. Tedavi
sonrası lezyon bölgesindeki akıntı ve yara yeri infeksiyonu tamamen düzeldi.
İncir (Ficus carica L.) Genetik Kaynaklarının Belirlenmesine Yönelik Bir Çalışma: Türkiye, Siirt Yöresi
Authors: GÜL Yasin , ÖZRENK Koray
Published: November 2019

Bu çalışma, Türkiye’nin Güneydoğu Anadolu
Bölgesi’nde yer alan ve incir popülasyonunun yoğunlukta olduğu Siirt ili Eruh ilçesi
Mışar Ovası’nda ve Siirt Merkez ilçeye bağlı Gökçebağ beldesinde yetiştirilen yerel
incir çeşitleri üzerinde yürütülmüştür. Çalışmada, yörenin incir gen kaynakları
araştırılmış, seçilen
ağaçlarda morfolojik ve fenolojik gözlemler yapılmış, toplanan meyve
örneklerinde pomolojik özellikler incelenmiş ve
kimyasal analizler yapılmıştır.
Pomolojik ve kimyasal özellikler yönünden incelenen çeşitlerin; meyve ağırlığı 2.31-64.82 g, ortalama
meyve boyu 20.00-52.50 mm, ortalama meyve eni 20.00-55.00 mm, meyvelerin suda çözünebilir kuru madde
miktarı % 9.00-32.00, titre edilebilir asitliği % 0.141-0.544 ve pH’sı
3.21-4.68 arasında değişim göstermiştir. Özellikle, Türkiye kurutmalık incir sektöründe ön planda olan sarılop
çeşidi ve sofralık incir piyasasında önemli yeri olan Bursa Siyahı çeşidi ile
benzer niteliklere sahip olduğu düşünülen genotiplerin varlığı tespit
edilmiştir.
Congratulations! JACIII Best Paper, Young Researcher, & Best Review Paper Awards 2019
Authors:   Editorial Office
Published: November 2019

We are pleased to announce that the JACIII Awards of 2019 have been decided by the JACIII Editorial Board. This year, the award winning papers were severely and fairly selected among 399 papers published in JACIII Vols. 20 (2016) to 22 (2018). The awarding achievements of 2019 are as follows:

 

JACIII BEST PAPER AWARD 2019

Title: Analyzing Potential of Personal Values-Based User Modeling for Long Tail Item Recommendation

Authors: Yasufumi Takama, Yu-Sheng Chen, Ryori Misawa, and Hiroshi Ishikawa

J. Adv. Comput. Intell. Intell. Inform., Vol.22 No.4, pp. 506-513, July 2018

 

JACIII YOUNG RESEARCHER AWARD 2019

Title: Characteristics of Rough Set C-Means Clustering

Authors: Seiki Ubukata, Keisuke Umado, Akira Notsu, and Katsuhiro Honda

J. Adv. Comput. Intell. Intell. Inform., Vol.22 No.4, pp. 551-564, July 2018

 

JACIII BEST REVIEW PAPER AWARD 2019

Title: A Survey of Video-Based Crowd Anomaly Detection in Dense Scenes

Authors: Junjie Ma, Yaping Dai, and Kaoru Hirota

J. Adv. Comput. Intell. Intell. Inform., Vol.21 No.2, pp. 235-246, March 2017
Interaction Between Population Aging and Technological Innovation: A Chinese Case Study
Authors: Li Xiang , Zhao Xindong ,   School of Economics and Finance, Huaqiao University No. 269, Chenghua North Road, Fengze District, Quanzhou, Fujian 362021, China,   Institute of Quantitative Economics, Huaqiao University No. 668, Jimei Avenue, Jimei District, Xiamen, Fujian 361021, China
Published: November 2019

Based on the method of unidirectional causality measure, this paper analyzes the long-term and short-term dynamic effects and causality between China’s population aging and technological innovation. According to the empirical results, first, the aging of the population will eventually have a continuous long-term impact, although it has little effect on the technology innovation in the short term. Second, when compared with the old-age dependency ratio, the child-raising ratio has a remarkable unidirectional causal effect on the technological innovation in the short term. Third, when compared with the old-age dependency ratio, the total dependency ratio has a stronger impact on the scientific and technological innovation ability, which is a long-term effect. The finding indicates that the elderly population and the children’s population have a continuous impact on China’s scientific and technological innovation, that is, the increase in social support burden affects the technological innovation for a long time.
Joint Trajectory Planning Based on Minimum Euclidean Distance of Joint Angles of a Seven-Degrees-of-Freedom Manipulator for a Sequential Reaching Task
Authors: Taniai Yoshiaki ,   Graduate School of Engineering, University of Fukui 3-9-1 Bunkyo, Fukui, Fukui 910-8507, Japan, Naniwa Tomohide
Published: November 2019

When a nuclear power disaster occurs at a nuclear power plant, it is hazardous for humans to enter the plant. If robots could remove radioactive substances adhering to a plane such as a plant wall, humans would be able to enter the plant to investigate the situation and to work. In this study, to efficiently remove radioactive substances from a wall with a manipulator, we examined joint trajectory planning based on the minimum Euclidean distance of joint angles of a seven-degrees-of-freedom (7-DOF) serial link manipulator for a sequential reaching task on a plane. We demonstrate the planning for the sequential reaching task, which is an iterative point-to-point reaching movement between positions on a plane. The joint angles for each target position were obtained based on the inverse kinematics for an arm angle, and the optimal arm angles within the constraints of the joint angles were computed by the sequential quadratic programming method. The optimal trajectories for the arm angles were compared with the trajectories of the joint angles that were the eight inverse kinematic solutions for a fixed arm angle. The result showed that through optimal planning, an efficient trajectory within the movable ranges of the joint angles could be obtained for the sequential reaching task.
Expression and Identification of Confidence Based on Individual Verbal and Non-Verbal Features in Human-Robot Interaction
Authors: Li Youdi ,   Tokyo Metropolitan University 6-6 Asahigaoka, Hino, Tokyo 191-0065, Japan, Hsieh Wei Fen , Sato-Shimokawara Eri , Yamaguchi Toru
Published: November 2019

In our daily life, it is inevitable to confront the condition which we feel confident or unconfident. Under these conditions, we might have different expressions and responses. Not to mention under the situation when a human communicates with a robot. It is necessary for robots to behave in various styles to show adaptive confidence degree, for example, in previous work, when the robot made mistakes during the interaction, different certainty expression styles have shown influence on humans’ truthfulness and acceptance. On the other hand, when human feel uncertain on the robot’s utterance, the approach of how the robot recognizes human’s uncertainty is crucial. However, relative researches are still scarce and ignore individual characteristics. In current study, we designed an experiment to obtain human verbal and non-verbal features under certain and uncertain condition. From the certain/uncertain answer experiment, we extracted the head movement and voice factors as features to investigate if we can classify these features correctly. From the result, we have found that different people had distinct features to show different certainty degree but some participants might have a similar pattern considering their relatively close psychological feature value. We aim to explore different individuals’ certainty expression patterns because it can not only facilitate humans’ confidence status detection but also is expected to be utilized on robot side to give the proper response adaptively and thus spice up the Human-Robot Interaction.
Reduced flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI
Authors: Corrado Philip A , Macdonald Jacob A. , Francois Christopher J. , Aggarwal Niti R. , Weinsaft Jonathan W. , Wieben Oliver
Published: November 2019

Background: Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI.
Methods: 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates.
Results: Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01).
Conclusions: A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany
Authors: Graf Jonas , Hartmann Christian , Lehmann Helmar C , Otto Carolin , Adams Ortwin , Karenfort Michael , Schneider Christian , Ruprecht Klemens , Bosse Hans Martin , Diedrich Sabine , Böttcher Sindy , Schnitzler Alfons , Hartung Hans-Peter , Aktas Orhan , Albrecht Philipp
Published: November 2019

BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases.RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and one EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. CONCLUSIONS: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.
Combined use of apatinib mesylate and vinorelbine versus single use of vinorelbine in recurrent or metastatic triple-negative breast cancer: study protocol for a randomized controlled clinical trial
Authors: Wu Shuo , Zhang Liang , Li Huan , Xu Junnan , Jiang Cui , Sun Tao
Published: November 2019

Background: The emergence of new molecular targeted drugs provides new prospects for the treatment of advanced breast cancer; the future therapeutic trend includes chemotherapy combined with molecular targeted therapy. Apatinib mesylate, a novel, small anti-angiogenic agent, highly selectively inhibits the activity of vascular endothelial growth factor receptor-2 tyrosine kinase. Apatinib mesylate also blocks the signaling of vascular endothelial growth factor binding to its receptor, thereby, strongly inhibiting tumor angiogenesis and exerting an anti-tumor effect. However, a randomized controlled clinical trial of apatinib combined with vinorelbine for triple-negative breast cancer (TNBC) has not been reported. We will compare the therapeutic effect of vinorelbine alone or in combination with apatinib mesylate in patients with recurrent or metastatic TNBC in North China who have received at least two drug treatments including anthracyclines and taxanes. Methods/analysis: This study is a triple-blind, randomized, placebo-controlled, parallel-group clinical trial. We plan to include 164 female patients with locally recurrent or metastatic TNBC and without BRCA1 mutation (as BRCA-positive patients would have poor responses to the therapeutic methods designed in this study), admitted at the Liaoning Cancer Hospital & Institute, Northeast China. All enrolled patients will be randomized to orally take vinorelbine alone (40 mg orally, thrice a week (Mondays, Wednesdays, and Fridays) in each 3-week cycle) or combined with apatinib mesylate (500 mg orally, once daily of each 3-week cycle). Radiographic assessment will be performed every 6 weeks for 36 weeks, and every 9 weeks thereafter. The primary outcome is measurement of progression-free survival and secondary outcomes include overall survival, disease control rate, objective response rate, and incidence of adverse events at grades 3 and 4 as defined by the National Cancer Institute Common Toxicity Criteria [NCI-CTC] Version 4.0. Outcome measures will be evaluated at baseline (< 2 weeks before starting treatment), every 6 weeks during treatment, and at 4 weeks and every 3 months after treatment discontinuation. Discussion: Based on the data from this trial, we hope to identify a treatment plan that is suitable for female TNBC patients in Northeast China who have been treated with anthracyclines and taxanes.
Using digital tools in the recruitment and retention in randomised controlled trials: Survey of UK Clinical Trial Units and a qualitative study
Authors: Blatch-Jones Amanda Jane , Nuttall Jacqueline , Bull Abby , Worswick Louise , Mullee Mark , Peveler Robert , Falk Stephen , Tape Neil , Hinks Jeremy , Lane Athene J , Wyatt Jeremy C , Griffiths Gareth
Published: November 2019

Background Recruitment and retention of participants in Randomised Controlled Trials (RCTs) is a key determinant of success, but is challenging. Trialists and UK Clinical Research Collaboration (UKCRC) Clinical Trials Units (CTUs) are increasingly exploring the use of digital tools to identify, recruit and retain participants. The aim of this UK National Institute for Health Research (NIHR) study was to identify what digital tools are currently used by CTUs and understand the performance characteristics required to be judged useful.Methods A scoping of searches (and a survey with NIHR funding staff), a survey with all 52 UKCRC CTUs and 16 qualitative interviews were conducted with five stakeholder groups including trialists within CTUs, funders and research participants. A purposive sampling approach was used to conduct the qualitative interviews during March-June 2018. Qualitative data were analysed using a content analysis and inductive approach.Results Responses from 24 CTUs (46%) identified that database-screening tools were the most widely used digital tool for recruitment, with the majority being considered effective. The reason (and to whom) these tools were considered effective was in identifying potential participants (for both Site staff and CTU staff) and reaching recruitment target (for CTU staff/CI). Fewer retention tools were used, with Short Message Service (SMS) or email reminders to participants being the most reported. The qualitative interviews revealed five themes across all groups: ‘security and transparency’, ‘inclusivity and engagement’, ‘human interaction’, ‘obstacles and risks’ and ‘potential benefits’. There was a high level of stakeholder acceptance of the use of digital tools to support trials, despite the lack of evidence to support them over more traditional techniques. Certain differences and similarities between stakeholder groups demonstrated the complexity and challenges of using digital tools for recruiting and retaining research participants.Conclusions Our studies identified a range of digital tools in use in recruitment and retention of RCTs, despite the lack of high quality evidence to support their use. Understanding the type of digital tools in use to support recruitment and retention will help to inform funders and the wider research community about their value and relevance for future RCTs. Consideration of further focused digital tool reviews and primary research will help to reduce gaps in the evidence base.
An exploration of the experiences of professionals supporting patients approaching the end of life in medicines management at home. A qualitative study. An exploration of the experiences of professionals supporting patients approaching the end of life in medicines management at home. A qualitative study.
Authors: Wilson Eleanor , Caswell Glenys , Latif Asam , Anderson Claire , Faull Christina , Pollock Kristian
Published: November 2019

Background: The management of medicines towards the end of life can place increasing burdens and responsibilities on patients and families. This has received little attention yet it can be a source of great difficulty and distress patients and families. Dose administration aids can be useful for some patients but there is no evidence for their wide spread use or the implications for their use as patients become increasing unwell.
Aim: To explore how healthcare professionals describe the support they provide for patients to manage medications at home at end of life.
Methods: Qualitative interview study with thematic analysis. Participants were a purposive sample of 40 community healthcare professionals (including GPs, pharmacists, and specialist palliative care and community nurses) from across two English counties.
Results: Healthcare professionals reported a variety of ways in which they tried to support patients to take medications as prescribed. While the paper presents some solutions and strategies reported by professional respondents it was clear from both professional and patient/family caregiver accounts in the wider study that rather few professionals provided this kind of support. Standard solutions offered included: rationalising the number of medications; providing different formulations; explaining what medications were for and how best to take them. Dose administration aids were also regularly provided, and while useful for some, they posed a number of practical difficulties for palliative care. More challenging circumstances such as substance misuse and memory loss required more innovative strategies such as supporting ways to record medication taking; balancing restricted access to controlled drugs and appropriate pain management and supporting patient choice in medication use.
Conclusions: The burdens and responsibilities of managing medicines at home for patients approaching the end of life has not been widely recognised or understood. This paper considers some of the strategies reported by professionals in the study, and points to the great potential for a more widely proactive stance in supporting patients and family carers to understand and take their medicines effectively. By adopting tailored, and sometimes, ‘outside the box’ thinking professionals can identify immediate, simple solutions to the problems patients and families experience with managing medicines.
HIV testing experiences in Nairobi slums: The good, the bad and the ugly
Authors: Wekesa Eliud
Published: November 2019

Background
HIV testing is an integral component of HIV prevention, treatment and care and, therefore, is crucial in achieving UNAIDS 90-90-90 targets. HIV testing in Kenya follows both the voluntary counselling and testing (VCT) and provider initiated testing and counselling (PITC) models. However, little is known about the individual experiences of undergoing an HIV test in the two testing models. This study provides experiential evidence of undergoing an HIV test in a resource poor urban slum setting.
Methods
The study explored testing experiences and challenges faced in respect to ensuring the 3 Cs (consent, counselling and confidentiality), using in-depth interviews (N=41) with HIV-infected men and women in two slum settlements of Nairobi City. The in-depth interview respondents were aged above 18 years with 56% being females. All interviews were audio-recorded, transcribed and then translated into English. The transcribed data were analysed using thematic analysis method.
Results
The respondent HIV-testing experiences were varied and greatly shaped by circumstances and motivation for HIV testing. The findings show both positive and negative experiences, with sporadic adherence to the 3Cs principle in both HIV testing models. Although some respondents were satisfied with the HIV testing process, a number of them raised a number of concerns, with instances of coercion and testing without consent being reported.
Conclusion
The 3Cs (consent, counselling and confidentiality) principle must underlie HIV testing and counselling practices in order to achieve positive testing outcomes. The study concludes that adherence to the 3Cs during HIV testing contributes to both the individual and public health good – irrespective of whether testing is initiated by the individual or by the health provider.

Keywords: HIV testing, VCT, PITC, PLWHA, Slums, Kenya, sub-Saharan Africa