bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiling of Sanitary Napkin Materials for Effective Menstrual Waste Management
Authors: Tendulkar Mamata , Ambadekar Sushama , Somaiya K. J.
Published: January 2024

Menstruation plays a crucial role in health and reproductive cycles of females. However, Menstrual Hygiene Management (MHM) poses significant challenges to many developing emerged in women's menstrual health and the environmental factors that influence it. This report represents the profiling of materials used during manufacturing of sanitary napkins to optimized practices required to manage and dispose menstrual waste effectively. Methodology: Various sanitary napkin brands were chosen based on popularity, affordability, and biodegradability. The selected brands were tested in accordance with the Bureau of Indian Standards (BIS) guidelines, using optimized procedures recommended by the textile committee. Around twenty-eight (n=28) napkins were tested for the same. Result: - The materials used for the top sheet, core absorbent material, and bottom sheet of each napkin were examined. Out of the 27 napkins tested, 12 napkins (35.71%) had natural fibre top sheets, 26 napkins (92.85%) had natural fiber absorbent materials, and all 27 napkins (100%) had synthetic bottoms. Conclusion: The majority of commonly used sanitary napkins are made of synthetic materials, and their absorbent gel components are not biodegradable. It is essential to explore alternative solutions for effectively managing this waste and promoting sustainable menstrual hygiene practices.
Physico-Chemical and Sensory Attributes of Developed Avocado Pulp-Carrot Juice Blended Probiotic Dahi as Effected by Different Packaging Materials
Authors: Gangaraju B. V. , Venkatesh M. , Rajanna M. , Babu A. Sachindra , jum An
Published: January 2024

A study was conducted for the development of value added dahi by incorporating avocado pulp and carrot juice to increase the nutritional and sensory quality. The research work was undertaken to develop the avocado pulp-carrot juice blended probiotic dahi to get functional attributes. Combination of Avocado pulp and carrot juice incorporated at the level 5.0, 10.0, 15.0 per cent, added with optimized probiotic culture (1 per cent) and combination of avocado pulp-carrot juice at 10.0 per cent was optimized for further trials. The control and developed avocado pulp-carrot juice blended probiotic dahi samples were packed in Polyethylene (C), Polystyrene (P1), Polypropylene (P2) and Polyethylene teraphthalate (P3) cups. The sensory evaluation of the samples showed significant effect on sensory scores. The overall acceptability score for P3 was found to be higher 8.41 as against 8.50 for control. The control and developed avocado pulp-carrot juice blended probiotic dahi samples packed in Polyethylene (C), Polystyrene (P1), Polypropylene (P2) and Polyethylene teraphthalate (P3) cups are stored at room temperature 30±1ËšC. The control and developed avocado pulp-carrot juice blended probiotic dahi samples packed in Polyethylene (C), Polystyrene (P1), Polypropylene (P2) and Polyethylene teraphthalate (P3) cups are stored at room temperature 30±1ËšC and analyzed for physico-chemical characteristics showed increased in acidity with decrease in pH in all the samples irrespective of the packaging material used. Moisture loss was also observed in the samples which resulted in increase of total solids and fat content to a lesser content. The packaging materials were found to have significant effect on the physic-chemical characteristics of the samples.
Antagonism Capability invitro of Trichoderma harziaum and Trichoderma viride against Pathogenic Fungi Colletotrichum gloeosporioides in Mangifera caesia Jack
Authors: Khotimah Khusnul , Hastuti Utami Sri
Published: January 2024

Mangifera caesia plant was a plant from Kalimantan which was now rarely found, due to the pathogenic fungi infection found on the leaves, thus it was able to obstruct photosynthesis process on the plant. One of attempts to hamper this pathogenic fungi growth was to present antagonistic fungi. The aims of this research: (1) to identify the highest antagonism effect of Trichoderma harzianum and T. viride, (2) to analyze the amount of enzyme produced from Trichoderma harzianum and T. viride, (3) to examine antagonism mechanism of Trichoderma harzianum and T. viride on Collectotrichum gloeosporioides fungi based on microscopic examination. The research method was multiple culture method inoculating antagonistic fungi: Trichoderma harzianum and T. viride also pathogenic fungi: Colletotrichum gloeosporioides on media of paired PDA plate, and then incubated at 250-270C for 4x24 hours. Next, the antagonism effect of Trichoderma harzianum and T. viride on Colletotrichum gloeosporioides, and the mechanism of antagonism would be examined by Scanning Electron Microscope (SEM), the results were analyzed descriptively and quantitatively. This research results referred that: (1) antagonistic fungi of Trichoderma harzianum has the highest antagonism power with the average percentage of antagonism 78,39% rather than T. Viridae fungi on Colletotrichum gloeosporioides, (2) cellulose enzyme produced by Trichoderma harzianum was greater, around 143,562 U/,L than T. Viridae fungi, (3) antagonism mechanism of Trichoderma spp. indicated that three mycoparasitism mechanisms in three methods: sticking, twisting, and piercing on hyphae fungi of Colletotrichum gloeosporioides.
Crop Production Technology of Tomato Crop for Indian Region
Authors: Ramgiry Pragya , Ramgiry Meenakshi
Published: January 2024

The modern production technology is very important for increasing production and productivity of the horticultural crops. By using modern production technology, we can save time by optimizing the smartly use of resources. The production technology tells us how to use inputs in an effective way. In crop production several factors affecting crop production including micro climate, soil fertility, availability of irrigation water and insect pests & diseases. How to manage these factors described by the productive production technology.
Overcoming Antibiotic Resistance
Authors: Biswas Sumit , Mandal Partha Pratim , Bhattacharya Susinjan , Mukherjee Soma
Published: January 2024

The main focus of this review article is to need for “an alternative to antibiotic usage in Agriculture and medicine”. Antibiotics, a group of chemicals, either derived from, or naturally produced that along with their synthetic analogues can kill microorganisms at low concentrations. Non-judicious use of these drugs leads to the development of resistance, untreatable and complicated emerging infections demanding search for an alternative. Inspite of new antibiotic and hybrid antibiotic development, natural antibiotics looks to be a promising option. Resistance to antibiotic degradation can lead to the ineffective breakdown of wastes and biomedical wastes because of evolutionary developments. Understanding of the breakdown of antibiotic resistance by use of natural antibiotics when interpreted with metabolic adaptations, biochemical pathways and thermodynamic changes will be of help to understand the problems in medicine and agriculture including development of new microbial species and suggest appropriate measures as the targeted therapeutic intervention in medicine. The work suggests on elucidation and enumeration of the pathways for antibiotic resistance transmission and identification of the prime causes of microbial evolution in environment resulting out from generation of antibiotic resistance. The present work hypothesizes on bioprospecting of natural substances with antimicrobial action to eradicate the problem of antibiotic resistance and suggests the use of natural antibiotics that can change the process of changed metabolic adaptations.
Invitro Evaluation of Botanicals and Bioagents against Colletotrichum gloeosporoides Causing Blight of Foxtail Palm
Authors: Vineeth M. , Reddy Trilok , Ravishankar L. V. , Gopi P. , Sai Charan B. Naga , Lakshmi Venkata , Huded Sharanabasav , Prasad Arcot Purna
Published: January 2024

Foxtail palm (Wodyetia bifurcata L.), is a graceful palm species native to Australia, belongs to family Arecaceae. It is recognized as valuable addition by palm enthusiasts and landscapers to be used in a wide spectrum of landscapes. Leaf blight is one of the emerging and serious disease of foxtail palm. The first evidence of disease appeared as minute circular to irregular spots, which were light-dark brown in colour, lightly sunken surrounded by brown margin and yellow halo. Studies on in vitro evaluation of botanicals and bioagents against blight of the foxtail palm were carried out in the department of Plant Pathology, College of Agriculture, Bengaluru. Among the botanicals evaluated maximum per cent inhibition (65.60 %) was recorded in Curcuma longa followed by Lantana camara (49.75 %). Least mycelial inhibition of fungus was recorded in Nicotiana tabacum (17.09 %) showing its least effectiveness against Colletotrichum gleosporoides. Among bacterial bioagents Bacillus subtilis (36.85 %) showed evaluated maximum inhibition percentage which was followed by Bacillus megaterium (35.74 %). Pseudomonas fluroscens has shown least inhibition of 30.37 per cent against C. gloeosporoides. Among the fungal bioagents evaluated maximum (55.93 %) inhibition of mycelial growth was noticed in Trichoderma harzianum followed by T. hamatum (53.33 %) and T. asperellum (50.74 %).
Studies on Genetic Variability, Heritability and Genetic Advance in Field Pea (Pisum sativum L)
Authors: Lokesh P. , Kanwar R. R. , Kar Sonali , Sao A. , Gupta A. K. , R. Saxena Ravi , Mandavi J. S.
Published: January 2024

Study on association analysis for seed yield and its yield contributing traits in field pea genotypes for characters to identify genotypes to be used in future breeding programme. The result showed high GCV and PCV was recorded for the characters number of primary branches per plant (GCV= 25.12; PCV= 26.87) followed by seed yield per plant(23.70 ; 26.17), harvest index(%) (23.49; 25.00) and number of pods per plant(19.40 ; 21.19). If the value of PCV is higher than the GCV, suggested that the apparent variation is not only due to genotypic but also due to the influence of environment. High heritability coupled with high genetic advance as percentage of mean reported in harvest index (88.28%), number of primary branches per plant (87.41%), number of pod per plant (83.88%), seed yield per plant(82.04%), pod length (80.01%) and number of seed per pod (78.69%). This indicated substantial of additive genetic variance in expression of these characters and can be useful in hybridization and selection for higher pod yield.
Kepastian Hukum Pengenaan BPHTB kepada Pemilik Tanah dan / atau Bangunan yang Belum Bersetifikat dalam Rangka Pendaftaran Tanah Sistematis Lengkap
Authors: Azminazilah Azminazilah , Darmaini Yohanna , Amiludin Amiludin , Ahmad Dwi Nurfauziah , Razif Imran Bukhari
Published: January 2024

Land is the most important agrarian aspect of a country which has cultural, political, social, and economic value. The need for registration by the land owner, where this registration is carried out at the land office can guarantee land control by a party by obtaining a land certificate. The certificate exists as proof that the party occupies and controls and has rights to the land. Disputes often lead to chaos or disparities due to commotion between communities fighting over land rights. Land Registration According to Article 1 Paragraph 1 of Government Regulation Number 24 of 1997 is the continuation of activities carried out by public bodies in a place that are continuous and regular, including sorting, handling, bookkeeping, as well as presenting and maintaining actual and juridical information. Information, as a guide and note, regarding a collection of information. The Land Rights Registrar can revoke tax levies if there is valid evidence through an authentic deed of land maintenance and registration. This tax collection will later be deposited by the Land Rights Registrar to the regional revenue office usually abbreviated to the Regional Revenue Office to provide legal certainty and protection for interested parties. Land registration activities are a form of government concern and fees for registering land and building rights are a form of tax on land registration. This tax is to ensure the continuity of land rights owned by individuals or entities over that land.
Implikasi Hukum dan Kekuatan Pembuktian Akta Jaminan Fidusia yang Penandatanganannya Tidak Dilakukan di Hadapan Notaris
Authors: Herliyani Herliyani
Published: January 2024

Notaries must sign the deed in front of the parties and witnesses, but in practice this signing is often not done in front of the parties and witnesses, giving rise to legal implications. This research discusses the legal implications of signing a deed that is not carried out in the presence of a notary and the evidentiary strength of a fiduciary guarantee deed whose signing is not carried out in the presence of a notary. The research method used is normative research, using a statutory approach and a conceptual approach, using secondary data which will be analyzed using descriptive analysis. The results of this research are that the legal implications of signing a deed that is not done in the presence of a notary means that the deed will turn into a private deed. Therefore, if the fiduciary guarantee deed is made privately, it does not fulfill the provisions of Article 5 paragraph (1) UUJF, so the deed becomes invalid and cannot be registered at the Fiduciary Registration Office and the evidentiary power of the fiduciary guarantee deed whose signing is not carried out in before a notary, making the deed only have the power of proof of a private deed, a private deed only has the power of formal proof, namely if the signature on the deed is acknowledged (in this case it is proof of recognition) which means the statement stated in the deed recognized and justified.
Investigation of the Casimir Effect in the Hubble Universe and Black Holes
Authors: Haug Espen , Wojnow Stephane
Published: January 2024

The Casimir effect can either work over very short distances or at very low temperatures. At the cosmic scale, we naturally deal with long distances, but at the same time, we encounter extraordinarily low temperatures, namely the CMB (Cosmic Microwave Background) tem- perature. Recently, there has been increased interest in the Casimir effect and its implications in cosmology. Here, we briefly demonstrate that the luminosity and radiation pressure of the CMB is mathematical identical to a theoretical Casimir effect within the Hubble sphere, or actually our solution seems to be valid for any Schwarzschild black hole. The Casimir effect forevery Schwarzschild black hole is identical. This also include the Hubble sphere if we treat it as a Schwarzschild black hole that is related to increased interest in black hole cosmology.
On the Precise Link Between Energy and Information
Authors: Witkowski Cameron , Brown Stephen , Truong Kevin
Published: January 2024

We present a modified version of the Szilard Engine, demonstrating that an explicit measurement procedure is entirely unnecessary for its operation. By considering our modified engine, we are able to provide a new interpretation of Landauer’s original argument for the cost of erasure. From this view, we demonstrate that a reset operation is strictly impossible in a dynamical system with only conservative forces. Then, we prove that to approach a reset yields an unavoidable instability at the reset point. Finally, we present an original proof of Landauer’s principle that is completely independent from the Second Law of Thermodynamics.
Content Protection Method for Remote Sensing Images Based on Deep Information Hiding
Authors: Luo Peng , Liu Jia , Mu Jun de
Published: January 2024

To ensure the security of highly sensitive remote sensing images (RSI) during their transmission, it is essential to implement effective content security protection methods. Generally, secure distribution schemes for remote sensing images often employ cryptographic techniques. However, sending encrypted data exposes communication behavior, which poses significant security risks to the distribution of remote sensing images. Therefore, this paper introduces deep information hiding to achieve secure distribution of remote sensing images, which can serve as an effective alternative in certain specific scenarios. Specifically, the Deep Information Hiding for RSI Distribution (hereinafter referred to as DIH4RSID) based on encoder-decoder network architecture with Parallel Attention Mechanisms (PAM) by adversarial training was proposed. Our model is constructed with four main components: a preprocessing network (PN), an embedding network (EN), a revealing network (RN) and a discriminating network (DN). The PN module is primarily based on Inception to capture more details of RSI and targets of different scales. The PAM module obtains features in two spatial directions to realize feature enhancement and context information integration. The experimental results indicate that our proposed algorithm achieves relatively higher visual quality and secure level compared to related methods. Additionally, after extracting the concealed content from hidden images, the average classification accuracy is unaffected.
Dual-Energy Computed Tomography in Detecting and Predicting Lymph Node Metastasis in Malignant Tumor Patients: A Comprehensive Review
Authors: Chen Mengting , Jiang Yundan , Zhou Xuhui , Wu Di , Xie Qiuxia
Published: January 2024

The accurate and timely assessment of lymph node involvement is paramount in the management of patients with malignant tumors, owing to its direct correlation with cancer staging, therapeutic strategy formulation, and prognostication. Dual-energy computed tomography (DECT), as a burgeoning imaging modality, has shown promising results in the diagnosis and prediction of preoperative metastatic lymph nodes in recent years. This article aims to explore the application of DECT in identifying metastatic lymph nodes (LNs) across various cancer types, including but not limited to thyroid carcinoma (focusing on papillary thyroid carcinoma), lung cancer, and colorectal cancer. Through this narrative review, we aim to elucidate the clinical relevance and utility of DECT in the detection and predictive assessment of lymph node metastasis in malignant tumors, thereby contributing to the broader academic discourse in oncologic radiology and diagnostic precision.
Enhancing Urban Resilience: Smart City Data Analyses, Forecasts, and Digital Twin Techniques at the Neighborhood Level
Authors: Gkontzis Andreas F. , Kontsiantis Sotiris , Feretzakis Georgios , Verykios Vassilios S.
Published: January 2024

Smart cities, leveraging advanced data analytics, predictive models, and digital twin techniques, offer a transformative model for sustainable urban development. Predictive analytics plays a crucial role in proactive planning, enabling cities to adapt to evolving challenges. Concurrently, digital twin techniques provide a virtual replica of the urban environment, fostering real-time monitoring, simulation, and analysis of urban systems. This research underscores the significance of real-time monitoring, simulation, and analysis of urban systems to support test scenarios that identify bottlenecks and enhance smart city efficiency. The paper delves into the crucial roles of citizen report analytics, prediction, and digital twin technologies at the neighborhood level. The study integrates ETL/ELT processes, AI techniques, and a digital twin methodology to process and interpret urban data streams derived from citizen interactions with the city's coordinate-based problem mapping platform. By employing an interactive GeoDataFrame within the digital twin methodology, dynamic entities facilitate simulations based on various scenarios. This approach enables users to visualize, analyze, and predict the response of the urban system at the neighborhood level. Consequently, antecedent and predictive patterns, trends, and correlations are visualized at the physical level of each city area, leading to improvements in urban functionality, resilience, and resident quality of life.
Numerical Simulation of a Dovetail Tee and Its Role in Pipeline Improvement at LNG Fueling Stations
Authors: Kang Zhangyang , Tan Rufei , Yao Qiongqiong , Zhang Junmiao
Published: January 2024

Certain configurations of liquefied natural gas refueling stations exhibit a deficiency in managing boil-off gas. Furthermore, the ill-conceived linkage between the submersible pump and the gas storage tank pipeline leads to impeded natural gas transmission. This study employs Computational Fluid Dynamics (CFD) methodology to scrutinize the hydrodynamic attributes of T-type tee and dovetail tee configurations implemented in the pipeline design connecting the submersible pump and storage tank in an LNG filling station across diverse operational scenarios. The T-type tee induces detachment of the primary flow from the inner wall due to inertial forces, resulting in vortex formation and heightened resistance, accompanied by increased energy dissipation. Conversely, the dovetail tee, with its circular wall transition, mitigates vortex generation, reducing the separation zone and consequently minimizing resistance and energy loss. The maximum static differential pressure between the inlet and outlet of the dovetail tee is diminished by 52.52% when compared to that of the T-type tee. In the most noteworthy scenarios, the local resistance coefficient of the dovetail tee is even less than 1/10 of that of the T-type tee. In practical engineering applications, the incorporation of dovetail tees leads to a 17.58% reduction in the required elevation difference. This results in a more uniform flow field and enhanced stability in both flow rate and pressure. Such improvements contribute to heightened engineering efficiency and environmental sustainability, particularly evident in the design of LNG filling stations.
Optimizing Chitin Extraction and Chitosan Production From Domestic Cricket Flour
Authors: Espinosa-Solís Andrea , Velázquez-Segura Angélica , Lara-Rodríguez Carlos , Martínez Luz María , Rodríguez-Sifuentes Lucio , Chuck-Hernández Cristina
Published: January 2024

Chitin and its derivative, chitosan, have diverse applications in fields such as agriculture, medicine, and biosensors, amongst others. Extraction is primarily conducted from marine sources, such as crustaceans, which have been the focus of optimization process studies. However, there are other sources that are more readily available, such as insects, where insufficient research has been conducted. The house cricket (Acheta domesticus) is a promising source for chitin extraction because of its high chitin content, availability, and short lifespan. Modern chemical chitin extraction methods have not been standardized due to the use of different reagents, molar concentrations, temperatures, and reaction times across publications. Therefore, in this study, the compositional analysis of Acheta domesticus cricket flour was determined: 2.62% humidity, 4.3% ash content, 56.29% protein, 13.35% fat, 23.44% carbohydrates, and 15.71% crude fiber content. After a drying, defatting, demineralization, deproteinization, and bleaching process, chitin extraction was performed, and chitosan was obtained via a deacetylation reaction. The demineralization process was standardized at 30ºC for 3 hours using HCl 2M, resulting in 95.85 ± 0.012%. The deproteinization process was optimized at 80ºC for 45 minutes using NaOH 2.56 M, yielding 46.37 ± 3.86%. Finally, the identity and physicochemical characteristics of the compounds were determined through characterization with FTIR, XRD, SEM and DSC.
Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells
Authors: Alves Talita Gabriela Luna , Xavier Pedro Luiz Porfirio , Garnica Taismara Kustro , Rochetti Arina Lázaro , Vendramini Thiago Henrique Annibale , Haddad Felipe , Munir Muhammad , Brunetto Márcio Antonio , Fukumasu Heidge
Published: January 2024

Lymphoma is the most prevalent type of cancer in cats, and the search for alternative treatments is of utmost importance given the significant number of animals that exhibit tumor recurrence or are unresponsive to conventional chemotherapy treatment. Oncolytic viruses possess a unique ability to target and eliminate cancer cells while simultaneously stimulating an immune response against these malignant cells. The present study aimed to explore the oncolytic potential of Newcastle Disease Virus expressing green fluorescent protein (NDV-GFP) in a feline leukemia virus (FeLV)-positive lymphoma cell line. Our research suggests that NDV-GFP has a propensity to selectively target, infiltrate, and replicate with-in feline lymphoma cells, resulting in the induction of apoptosis in these cells, as opposed to non-tumor cells. Therefore, our research provides evidence supporting the development of novel oncolytic therapies based on NDV for the treatment of feline lymphomas.
Long-Read Sequencing and De Novo Genome Assembly Pipeline of Two Plasmodium falciparum Clones (Pf3D7, PfW2) Using Only the PromethION Sequencer from Oxford Nanopore Technologies without Whole Genome Amplification
Authors: Delandre Océane , Lamer Ombeline , Loreau Jean-Marie , Papa Mze Nasserdine , Fonta Isabelle , Mosnier Joel , Gomez Nicolas , Javelle Emilie , Pradines Bruno
Published: January 2024

Antimalarial drug resistance has become a real public health problem despite WHO measures. New sequencing technologies make it possible to investigate genomic variations associated with resistant phenotypes at the genome-wide scale. Based on the use of hemisynthetic nanopores, the PromethION technology from Oxford Nanopore Technologies can produce long-read sequences, in contrast to previous short-read technologies used as gold-standard to sequence Plasmodium. Two clones of P.falciparum (Pf3D7 and PfW2) were sequenced in long-read using the PromethION sequencer from Oxford Nanopore Technologies without genomic amplification. This made it possible to create a processing analysis pipeline for human Plasmodium with ONT Fastq only. De novo assembly revealed N50 lengths of 18,488 kb and 17,502 kb for the Pf3D7 and PfW2, respectively. The genome size was estimated at 23,235,407 base pairs for the Pf3D7 clone and 21,712,038 base pairs for the PfW2 clone. The average genome coverage depth was estimated at 787X and 653X for the Pf3D7 and PfW2 clones, respectively. This study proposes an assembly processing pipeline for the human Plasmodium genome using software’s adapted to large ONT data and the high AT percentage of Plasmodium. This search provides all the parameters, which have been optimized, for use with the software selected in the pipeline.
Simulating Water Vapor Removal in Glycol Gas Dehydration Mechanisms: A Comprehensive Analysis of Natural Gas and Dry Nitrogen.
Authors: JOHNSON. NNADIKWE , UME CYRIL SUNDAY , NWOSI HEZEKIAH ANDREW
Published: January 2024

Natural gas is an important energy source among various fossil fuels. However, natural gas typically contains a significant amount of water vapor, which can pose challenges in its usage. Therefore, the process of removing water vapor from natural gas, known as gas dehydration, is crucial in the gas industry. The presence of water vapor in the gas supply can lead to the formation of hydrates, which can cause issues such as blockages in pipelines. To tackle this problem effectively, gas dehydration makes use of Tri ethylene glycol (TEG) as a drying agent. TEG works by selectively absorbing water vapor from the natural gas flow, thereby significantly reducing its moisture content.In the gas dehydration process, wet gas is treated by using lean glycol in an absorber, where the water vapor is removed. The resulting rich glycol is then recovered and recycled for further use. In this study, we explore the possibility of replacing nitrogen with dry natural gas in the re-generator of the glycol dehydration system. The aim is to evaluate the feasibility and effectiveness of this alternative approach. To assess the performance of both techniques, we employed HYSYS modeling and simulation. Through this analysis, we compared the capital and utility expenses associated with each method while ensuring that the glycol purity requirements remained unchanged. By examining the results obtained from the simulations, we can gain insights into the economic viability and efficiency of utilizing dry natural gas in the re-generator stage of the glycol dehydration process.In addition to the primary purpose of removing water vapor, the wet gas obtained from the stripping mechanisms in the glycol dehydration process can serve additional functions. It can be utilized to power steam pumps and compressors, thereby maximizing energy efficiency within the system. Alternatively, the wet gas can be recycled back into the process for further treatment. To develop a comprehensive understanding of the entire mechanism, we constructed a model based on the actual flow diagram. This model takes into account the various components and processes involved in the glycol dehydration system, including the stripping mechanisms and their connection to other equipment. By analyzing the data and outcomes generated by this model, we can derive valuable insights. These findings can be utilized to optimize the heat and material balance within the plant, ensuring efficient operation and potentially leading to the design of an improved system in terms of energy consumption and overall performance
The Language of Spheres in Physics
Authors: Gazeau Jean-Pierre
Published: January 2024

Physical laws find expression through combinations of mathematical symbols, numbers, functions, geometries, and relations. These amalgamations unfold within a mathematical model designed to represent the “objective reality” of the system under scrutiny. The language used and the associated concepts are in a perpetual state of evolution, mirroring the ongoing expansion of the phenomena accessible to our scientific understanding. In this contribution, we delve into fundamental, at times seemingly elementary, elements of the mathematical language inherent to the physical sciences, guided by the overarching principles of symmetry and group theory. Our focus turns to the captivating realm of spheres, those strikingly symmetric entities that manifest prominently within our geometric landscape. By exploring the interplay between mathematical abstraction and the tangible beauty of symmetry, we seek to deepen our understanding of the underlying structures that govern our interpretation of the physical world.
miR-223, but Not miR-195, Modulates Myocardial-Induced Proepicardial Cell Migration
Authors: Lozano-Velasco Estefanía , Aranega Amelia , Franco Diego
Published: January 2024

Cardiac development is a complex developmental process that results in the formation of the four-chambered organ from a single linear heart tube. In the early stages of development, the linear heart tube is composed of only two tissue layers, an external myocardium that is internally lined by the endocardium. Subsequently, the proepicardium emerges at the septum transversum and soon thereafter proepicardial cells will migrate into the naked myocardium, leading to the formation of the embryonic epicardium. As cardiac development proceeds, epicardial-derived cells migrate into the subepicardial space and subsequently invade the developing ventricular chambers leading to the contribution of distinct cardiovascular cell types such as the cardiac fibroskeleton and different components of coronary vasculature. At present, the molecular mechanisms that regulate the transitional process from the proepicardium to the embryonic myocardium are largely unexplored. In this study we have implemented an ex vivo proepicardium/septum transversum (PE/ST)-embryonic myocardium explant model and we demonstrated that miR-223, but not miR-195, is capable of modulating PE/ST migration, a process that seems to be mediated by Slug expression. Thus, our study demonstrates for the first time the implication of distinct microRNAs in the PE/ST to embryonic myocardium transition in chicken embryonic hearts.
Inverse Problems in Pump-Probe Spectroscopy
Authors: Tikhonov Denis S. , Garg Diksha , Schnell Melanie
Published: January 2024

Ultrafast pump-probe spectroscopic studies allow for deep insights into the mechanisms and timescales of photophysical and photochemical processes. Extracting valuable information from these studies, such as reactive intermediates' lifetimes and coherent oscillation frequencies, is an example of the inverse problems of chemical kinetics. This article describes a consistent approach for solving this inverse problem that avoids the common obstacles of simple least-squares fitting that can lead to unreliable results. The presented approach is based on the regularized Markov Chain Monte Carlo sampling for the strongly nonlinear parameters, allowing for a straightforward solution of the ill-posed nonlinear inverse problem. The software to implement the described fitting routine is introduced and the numerical examples of its application are given. We will also touch on critical experimental parameters, such as the temporal overlap of pulses and cross-correlation time and their connection to the minimal reachable time resolution.
First Case Report of Sunvozertinib for the Treatment of Her2 Exon 20 Insertion in Lung Adenocarcinoma
Authors: Luan Tao , Lin Xin Qing , Xie Xiao Hong , Wang Shuai Yin , Lu Heng , Liu Lian sheng , Yang Gang , Zhang Yun Hui , Zhou Cheng Zhi
Published: January 2024

Human Epidermal Growth Factor Receptor 2(HER2) is a transmembrane glycoprotein receptor with intracellular tyrosine kinase activity. It is generally considered as a poor prognostic marker. Targeted therapies, such as small molecule tyrosine kinase inhibitors (TKIs), showed limited efficacy in HER2-mutant advanced Non-Small Cell Lung Cancer (NSCLC). In the 2023 NCCN guidelines for NSCLC, Antibody-Drug Conjugate(ADC) Trastuzumab emtansine (T-DM1) is recommended for the treatment of HER2-mutant Lung Cancer (LC). However, this medication is currently not approved in certain regions.So it is necessary to explore alternative treatment options for HER2-mutant NSCLC patients.In our study of a patient with HER2 exon 20ins Lung Adenocarcinoma who had previously failed multiple TKI treatments, we discovered that Sunvozertinib could stabilize the patient's condition, achieving a progression-free survival (PFS) of 87 days. This is a novel finding that may provide new treatment options for HER2 exon 20ins patients who have failed TKI therapy.
Common Concepts and Theories between Fisheries Management and Other Environmental Issues
Authors: Matsuda Hiroyuki
Published: January 2024

This paper explores the application of fisheries management theories to broader environmental issues, including climate change and biodiversity conservation. It underscores the inherent trade-off in fisheries between yield and resource conservation, identifying harvesting as a significant environmental burden. Early recognition of the sustainability concept aimed to address challenges like economic discounts and the tragedy of the commons, contributing to the issue of overfishing. These insights extend beyond fisries to other environmental concerns, particularly climate change. The development of adaptive management, initially tailored to address uncertainties and non-stationarity in fisheries, has found application in diverse environmental issues. Recognizing humans as integral parts of ecosystems highlights the impossibility of achieving zero environmental impact when utilizing natural resources. The paper advocates for passive restoration to prevent overfishing, leveraging nature's resilience. While goals like complete biodiversity restoration are inherent in fisheries, their relevance may not be immediately apparent to other environmentalists. Despite ongoing discussions on the sustainability of ecosystem services, legislation often tends to favor the long-term maximization of fisheries yield. The paper calls for mutual understanding of theories and experiences across various environmental fields, including fisheries, to enhance collaborative efforts in each field.
Impact Sound Reduction of Additional Floor Mats for Retrofitting of Existing Apartment Building Performances in Accordance With Test-Bed Conditions
Authors: Kim Yong-Hee , Moon Soon-Seong , Yeon Jun-Oh
Published: January 2024

Floor mats are commonly used to improve the impact sound performance of existing homes, but the actual reduction does not consistently appear depending on the test-bed conditions used to determine it. Therefore, this study evaluated the effects of the environmental conditions of the test-bed on the impact sound reduction performance of different floor mats. The Korean Industrial Standard, KS F 2865, specifies the measurement method in the test room and sets the thickness range of the available target floor structure from bare slab 120 mm to 210 mm. The evaluation method is ∆?, which is the difference in standardized impact sound levels before and after the installation of the floor finishing material. In this study, a total of eight types of floor mats were tested in four different test-beds according to KS F 2865. The impact sources used were tapping, bang machines and a rubber ball to consider both light-weight and heavy-weight impact sounds. The results were derived as impact sound reduction performance for each frequency band and a single number quantity. The results showed that light impact sound had a similar minimum reduction characteristic of at least 38 dB, regardless of the floor structure on which the mat was installed. However, the heavy-weight impact sound showed different tendencies depending on the floor mat and the characteristics of the floor structure of the test-bed when a bang machine and a rubber ball were used. In particular, the reduction by the bang machine showed less than half the tendency of the reduction by the rubber ball, and the tendency of the heavy-weight impact sound to be reduced depending on the floor mat was maintained, but the reduction differed depending on the test bed. The reduction was larger in the box-type test room than in the real-life type test room, and among the box-type test rooms, the one with a thicker bare slab showed a relatively larger reduction. In addition, the reliability of the measurement results was discussed through the correlation analysis between the single number quantities depending on the thickness of the bare slab of the test-beds.
Collaborative Semantic Annotation Tooling (CoAT) to Improve Efficiency and Plug-and-Play Semantic Interoperability in Secondary Use of Medical Data: Concept, Implementation, and First Cross-Institutional Experiences
Authors: Wiktorin Thomas , Grigutsch Daniel , Erdfelder Felix , Heidel Andrew J. , Bloos Frank , Ammon Danny , Löbe Matthias , Zenker Sven
Published: January 2024

Cross-institutional secondary use of medical data benefits from structured semantic annotation, which, ideally, enables matching and merging semantically related data items from different sources and sites. While numerous medical terminologies and ontologies, as well as some tooling, exist to support such annotation, cross-institutional data usage based on independently annotated datasets is challenging for multiple reasons: the annotation process is resource intensive and requires a combination of medical and technical expertise since it often requires judgment calls to resolve ambiguities resulting from non-uniqueness of potential mappings to various levels of ontological hierarchies and relational and representational systems. Divergent resolution of such ambiguities can inhibit joint cross-institutional data usage based on semantic annotation since data items with related content from different sites will not be identifiable based on their respective annotations if different choices were made without further steps such as ontological inference, which is still an active area of research. We hypothesize that a collaborative approach to semantic annotation of medical data can contribute to more resource efficient and high-quality annotation by utilizing prior annotational choices of others to inform the annotation process, thus both speeding up the annotation itself and fostering a consensus approach to resolving annotational ambiguities by enabling annotators to discover and follow pre-existing annotational choices. Therefore, we have implemented a prototypical Collaborative Annotation Tool (CoAT), evaluated its usability, and present first inter-institutional experiences with this novel approach to promoting practically relevant interoperability driven by use of standardized ontologies.
Partial mGlu5 Receptor NAM, M-5MPEP, Induces Rapid and Sustained Antidepressant-like Effects in the BDNF-dependent Mechanism and Enhances (R)-Ketamine Action in Mice
Authors: Pałucha-Poniewiera Agnieszka , Rafało-Ulińska Anna , Santocki Michał , Babii Yana , Kaczorowska Katarzyna
Published: January 2024

Partial negative allosteric modulators (NAM) of the mGlu5 receptor are an excellent alternative to full antagonists and NAMs because they retain some therapeutic effects and, at the same time, have a much broader therapeutic window. Here, we investigated whether partial mGlu5 NAM, M-5MPEP induced a fast and sustained antidepressant-like effect, characteristic of rapid-acting antidepressant drugs (RAADs) like ketamine, in C57BL/6J mice. M-5MPEP caused a rapid, dose-dependent antidepressant-like action in the tail suspension test (TST) 60 min after injection. This effect was antagonized by an AMPA receptor antagonist (NBQX) and a TrkB receptor antagonist (ANA-12) but not by 5HT1A and 5HT2A/2C receptor antagonists. Furthermore, M-5MPEP (30 mg/kg) induced sustained antidepressant-like effects 24 h after the last of four administrations. These effects were revealed in the splash test, designed to measure apathy-like state, and in the TST. Western blot and ELISA analyses indicated the involvement of the TrkB/BDNF pathway in the sustained M-5MPEP effects. Additionally, prolonged effects of M-5MPEP were entirely reversed by the TrkB receptor antagonist ANA-12 in both the splash test and the TST, confirming the critical role of TrkB receptor activation in the sustained antidepressant-like effect of M-5MPEP. Importantly, M-5MPEP enhanced the subthreshold dose of (R)-ketamine in the TST, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression.
Transcranial Magnetic Stimulation to Treat Neuropathic Pain: A Bibliometric Analysis
Authors: Carneiro Bruno Daniel , Tavares Isaura
Published: January 2024

Neuropathic pain is caused by a lesion or disease of the somatosensory system and is one of the most incapacitating pain types, representing a significant non met medical need. Due to the increase in research in the field and since innovative therapeutic strategies are required, namely in intractable neuropathic pain, neurostimulation has been used. Within this approaches, transcranial magnetic stimulation (TMS) that uses a transient magnetic field to produce electrical currents over the cortex emerges in the literature. Since this is an area in expansion and due to the putative role of TMS, we performed a bibliometric analysis in Scopus with the primary objective of identify the scientific production related to the use of TMS to manage neuropathic pain. The research had no restrictions and the analysis focused on the characteristics of the literature retrieved, scientific collaboration and main research topics from inception to July 6, 2023. A total of 474 articles were collected. A biggest co-occurrence between the terms “neuropathic pain” and “transcranial magnetic stimulation” was obtained. The journal “Clinical Neurophysiology” leads the Top 5 most productive sources. The United States is the most productive country with 50% of the documents being “review articles” followed by France with 56% of the documents being “original articles”. Lefaucheur, JP and Saitoh, Y are the two most influents authors. The most frequent type of documents was “original article”. This study allows to perform a general overview in the field of TMS application for neuropathic pain and is useful to establish future directions of research in this field.
Behavioral Health Services Outcomes That Matter Most to Caregivers of Children, Youth, and Young Adults with Mental Health Needs
Authors: Graaf Genevieve , Kitchens Katherine , Sweeney Millie , Thomas Kathleen C
Published: January 2024

To support the development of research evidence and behavioral health policy that aligns with the priorities of youth and families serviced in child and youth mental health systems, this project documents the service outcomes that caregivers value most. A diverse group of caregivers, representing six regions of the United States, participated in two rounds of virtual one-hour focus groups. In round 1, participants identified what they hoped to gain from using behavioral health services for themselves, their families, and their child and discussed what made services a positive experience for them. They then reported their top three most hoped for outcomes. In round 2, groups validated and refined summary findings from round 1. Caregivers prioritize service quality outcomes, primarily. They expressed a desire for an accessible, respectful, and supportive treatment environment underpinned by well-trained and culturally responsive professionals. Caregivers also desire seamless cross-sector provider collaboration and care transitions which integrate the insights and preferences of families and children themselves to craft a customized care plan. Priority outcomes not related to service quality included hoping to gain increased knowledge, resources, and tools and techniques to support the mental health needs of their children, help them improve their daily functioning, and develop more effective interpersonal communication skills. Caregivers also reported hoping to experience less stigma related to the mental health needs of their children and to achieve personal fulfillment for themselves and their children. Research and policies should prioritize and be designed to address the outcomes that matter to youth and families.
Can States Become Wealthier While Keeping Livestock Intensification Low? Evidence From India
Authors: Khire Ishan , Ryba Ren
Published: January 2024

Rising demand and urbanization have led to the global increase and intensification of livestock production. Intensive production has harmful effects on the environment, public health (due to the emergence of zoonotic diseases), and animal welfare. In order to better understand how livestock production intensifies as countries develop and incomes rise, we examine the relationship between income per capita and intensification of poultry and cattle, using the states of India as a study region. We also replicate this analysis at the district level to test whether the relationship holds at different spatial scales. We identify outlying states and districts to see if there are policies that can keep agriculture production largely extensive, even as economic growth occurs. The results support the relationship of income being positively correlated with the proportion of livestock in intensive conditions. However, there are notable outlier states which have grown wealthy while still maintaining largely extensive production, indicating that there may be some cases where economic growth can occur without intensification.