bluuebunny/crossref_metadata_2025 huggingface dataset:
A coherent trio of, distance and size based, measures for nomic and actual truthlikeness
Authors: Kuipers Theo A. F.
Published: February 2023

So far, the most prominent measure for actual truthlikeness, i.e. the likeness of a theory to the actual truth, is Ilkka Niiniluoto’s minsum definition, which is purely based on distances. A competing definition is the average distance measure proposed by Pavel Tichy and Graham Oddie. We will define three related, distance and size based, measures for actual truthlikeness and compare them with the two well-known options. However, we will start, Sect. 2, from a trio of such measures for nomic truthlikeness. The nomic truth, or the true theory, here refers to what is nomically, e.g. physically, possible. In a nomic (and factual) context there are two basic kinds of theories, viz. either based on an exclusion claim or on an inclusion claim. Two-sided theories combine these claims, with the maximal claim as extreme special case. We will base truthlikeness measures for exclusion, inclusion, two-sided, and hence maximal, nomic theories on two similarity measures, one in terms of distances between conceptual possibilities and the other in terms of sizes of sets of such possibilities. In Sect. 3 we will treat actual truthlikeness as extreme special case of nomic truthlikeness, viz. assuming that there is just one nomic possibility, the actual one. Next we will compare the resulting measures mutually and with the above mentioned measures of Niiniluoto and Tichy & Oddie. Finally, in Sect. 4, we will sum up the results and explore five questions for further research.
Genetic variability of the prion protein gene in Indonesian goat breeds
Authors: Pakpahan Suhendra , Widayanti Rini , Artama Wayan Tunas , Budisatria I. Gede Suparta , Lühken Gesine
Published: February 2023

Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goats. Resistance or susceptibility of small ruminants to classical scrapie is influenced by polymorphisms in the prion protein gene (PRNP). PRNP variability in Indonesian indigenous goat breeds has not been investigated so far and therefore was the goal of this study. Sanger sequencing of the PRNP gene coding region in 72 goats of the seven Indonesian breeds Kacang, Gembrong, Samosir, Kejobong, Benggala, Jawarandu, and Peranakan Etawah revealed three amino acid substitutions, namely W102G, H143R, and S240P. Some silent mutations were also found at codons 42 (a/g), 138 (c/t), and 179 (g/t). The PRNP alleles K222 and D/S146 known to have significant protective effects on resistance to classical scrapie in goats were not detected. The allele R143, which may have a moderate protective effect, had a frequency of 12% among the analyzed Indonesian goat breeds. While R143 was missing in Kacang and Benggala, its frequency was highest in the breed Gembrong (32%). No scrapie cases have been reported in Indonesia until now. However, in the case that selection for protective PRNP variants would become a breeding goal, the analyzed breeds will not be very useful resources. Other goat breeds which are present in the country should be investigated regarding resistance to scrapie, too.
Hydraulic Diagnostic Kit for the Automatic Expeditious Survey of in-line Valve Sealing in Long, Large Diameter Transmission Mains
Authors: Capponi Caterina , Brunone Bruno , Maietta Filomena , Meniconi Silvia
Published: February 2023

In long transmission mains (TMs), maintenance operations and repairs often require the preliminary closure of some of the installed in-line valves. If perfectly sealed, these valves avoid leakage and then the possible emptying of the pipelines, air entry through leaks, and the successive unwanted transients at the filling completion. The poor accessibility of TMs makes the check of the valve sealing quite difficult since in most cases the confined space where they are installed implies the adoption of severe prevention measures. Therefore, expeditious and possibly remote survey procedures are strongly required by pipe system managers. In this paper, an innovative technique based on the execution of safe transient tests is proposed. It is tested on the Dorsale TM – a long, large diameter pipe system – in the northeast of Milan, Italy, where the sealing of three in-line valves had to be checked. The analysis of the test results allows pointing out successfully not only the valves sealing, but also refining a quick and reliable procedure – the so called “diagnostic kit” – that leads the way to automatic and periodic checks of the valve sealing. In the proposed procedure – that can be straightforwardly exported to other TMs – only a single pressure measurement section is required, that significantly simplifies the survey.
On the radiotoxic 210Po in coffee beans worldwide and the impact of roasting and brewing on its extraction into beverages: from the experiments to 210Po content prediction
Authors: Olszewski Grzegorz , Moniakowska Aleksandra , Zhang Dan , Strumińska-Parulska Dagmara
Published: February 2023

We determined radiotoxic 210Po in roasted coffee beans from different regions worldwide, the beverages, and tried to create the prediction model of 210Po content based on its growth location. Additionally, the experiments on 210Po losses and extraction were performed to describe the actual exposure to 210Po. 210Po concentrations in coffee beans and brews tuned out low (maximally of 0.20 Bq∙kg−1 and 2.31 Bq∙L−1, respectively). We assessed the impact of the roasting process on 210Po content and its losses at a maximum of 56.7%. During infusion experiments, we estimated the extraction of 210Po to the coffee brew at a maximum of 40.6%. The amount of 210Po in the coffee brew depended on the infusion style and water type. We calculated the effective radiation doses from the coffee drink ingestion. Coffee drinking does not contribute significantly to the annual effective radiation dose worldwide.

Graphical Abstract
Carbon footprint of transhumant sheep farms: accounting for natural baseline emissions in Mediterranean systems
Authors: Pardo Guillermo , Casas Raquel , del Prado Agustín , Manzano Pablo
Published: February 2023

Purpose

Transhumance has rarely been analyzed through LCA approaches, and there is little evidence about its emissions level when conducted under different practices (by truck or on foot) or compared to sedentary livestock systems. Moreover, mobile pastoralism is strongly linked to natural resources by its seasonal grazing patterns, thereby occupying the niche of wild herbivores. Considering natural emission baselines in these ecosystems could have relevant effects when estimating their carbon footprint.

Materials and methods

Inventory data of 20 sheep farms was collected to estimate the carbon footprint (CF) of lamb meat produced. Farms were divided into three sub-groups representing typical management practices in the region: (1) sedentary (SED), (2) transhumance by truck (THT), and (3) transhumance on foot (THF). Livestock GHG emissions were modeled according to herd structure and IPCC guidelines. Off-farm emissions from external feeds and fuels were accounted based on existent LCA databases. A natural baseline of wild herbivores was established from the population of red deer reported in a hunting preserve, previously considered to be a reference for the natural carrying capacity in Mediterranean ecosystems. GHG emissions of wild herbivores were estimated through two methods based on (1) IPCC guidelines and (2) allometric regression equations.

Results and discussion

Carbon footprint ranged from 16.5 up to 26.9 kgCO2-eq/kg of lamb liveweight (LW). Significant differences were identified among sedentary and transhumant farms, the latter consistently showing lower CF values (SED: 25.1 kg CO2-eq/kg LW, THT: 18.3 kg CO2-eq/kg LW, THF: 18.2 kg CO2-eq/kg LW). Sedentary farms resulted in higher GHG emissions (+ 27%) and higher CO2 and N2O, contributions derived from the consumption of additional feeds. Both methods applied to compute emissions for wild herbivores led to similar results (25.3–26.8 Mg CO2-eq/km2), comparatively lower than estimation for transhumant sheep (47.7 Mg CO2-eq/km2). When considering natural baseline emissions, the CF of transhumant lamb meat is reduced by almost 30%, reaching values quite below those reported for intensive lamb production systems in Spain.

Conclusions

From our results, mobility of grazing livestock can be considered as a strategy promoting climate change mitigation. This is achieved mainly by reducing the need of external feeds, while maximizing the use of local forage resources that otherwise would be difficult to valorize. Further reductions in the CF result when considering natural baseline emissions. The application of this new GHG accounting perspective could have relevant implications when aiming at climate neutrality of grazing-based ruminant systems.
Safe surgical training: evaluation of a national functional endoscopic sinus surgery model simulation course using the Kirkpatrick evaluation model
Authors: Gillanders Sarah Louise , McHugh Alison , Lacy Peter D. , Thornton Mona
Published: February 2023

Background

Simulation is a rapidly developing field in modern undergraduate skills education and postgraduate surgical training.

Aim

We aim to evaluate simulation training as a tool for higher surgical training in functional endoscopic sinus surgery (FESS) using the Kirkpatrick evaluation model.

Methods

This was a prospective cohort study in which a qualitative survey and multiple-choice questionnaire were distributed to otolaryngology trainees pre- and post-FESS training course using simulation models. Participants’ reactions and interpretations of the models were assessed. Pre- and post-simulation knowledge and subjective skills were assessed.

Results

A total of 21 trainees completed the course. Trainees reported simulation models to be accurate representations of human anatomy 95% and easy to use 90%. There was an improvement in anatomical 54 to 62% (Z = 76, p0.03) and procedural 65 to 72% (Z = 87, p0.03) knowledge overall.

Conclusion

Simulation training is an effective method of postgraduate education. This has been particularly useful following reduced operative exposure in the COVID-19 era.
Health risk assessment for particulate matter: application of AirQ+ model in the northern Caribbean region of Colombia
Authors: Arregocés Heli A. , Rojano Roberto , Restrepo Gloria
Published: February 2023

Air pollution is considered the world’s most important environmental and public health risk. The annual exposure for particulate matter (PM) in the northern Caribbean region of Colombia between 2011 and 2019 was determined using PM records from 25 monitoring stations located within the area. The impact of exposure to particulate matter was assessed through the updated Global Burden of Disease health risk functions using the AirQ+ model for mortality attributable to acute lower respiratory disease (in children ≤ 4 years); mortality in adults aged > 18 years old attributable to chronic obstructive pulmonary disease, ischaemic heart disease, lung cancer, and stroke; and all-cause post-neonatal infant mortality. The proportions of the prevalence of bronchitis in children and the incidence of chronic bronchitis in adults attributable to PM exposure were also estimated for the population at risk. Weather Research and Forecasting-California PUFF (WRF-CALPUFF) modeling systems were used to estimate the spatiotemporal trends and calculate mortality relative risk due to prolonged PM2.5exposure. Proportions of mortality attributable to long-term exposure to PM2.5were estimated to be around 11.6% of ALRI deaths in children ≤ 4 years of age, 16.1% for COPD, and 26.6% for IHD in adults. For LC and stroke, annual proportions attributable to PM exposure were estimated to be 9.1% and 18.9%, respectively. An estimated 738 deaths per year are directly attributed to particulate matter pollution. The highest number of deaths per year is recorded in the adult population over 18 years old with a mean of 401 events. The mean risk in terms of the prevalence of bronchitis attributable to air pollution in children was determined to be 109 per 100,000 inhabitants per year. The maximum RR values for mortality (up 1.95%) from long-term PM2.5exposure were predicted to correspond to regions downwind to the industrial zone.
Endocrine Dysfunction After Traumatic Brain Injury: An Ignored Clinical Syndrome?
Authors: Mahajan Charu , Prabhakar Hemanshu , Bilotta Federico
Published: February 2023

Traumatic brain injury (TBI) incurs substantial health and economic burden, as it is the leading reason for death and disability globally. Endocrine abnormalities are no longer considered a rare complication of TBI. The reported prevalence is variable across studies, depending on the time frame of injury, time and type of testing, and variability in hormonal values considered normal across different studies. The present review reports evidence on the endocrine dysfunction that can occur after TBI. Several aspects, including the pathophysiological mechanisms, clinical consequences/challenges (in the acute and chronic phases), screening and diagnostic workup, principles of therapeutic management, and insights on future directions/research agenda, are presented. The management of hypopituitarism following TBI involves hormonal replacement therapy. It is essential for health care providers to be aware of this complication because at times, symptoms may be subtle and may be mistaken to be caused by brain injury itself. There is a need for stronger evidence for establishing recommendations for optimum management so that they can be incorporated as standard of care in TBI management.
The Kurdish kaçakçı on the Iran-Turkey border: corruption and survival as EU sponsored counter-smuggling effects
Authors: Augustova Karolina , Suber David Leone
Published: February 2023

This article examines people smuggling in the Kurdish borders between Turkey and Iran, and describes how members of local Kurdish border communities use their roles as kaçakçı (smuggler in Turkish) to navigate externalised EU border controls amid internal displacement and poverty. It draws upon ethnographic data collection between 2020 and 2022 in the Turkey-Iran border that has not been considered in studies on the EU-supported external counter-smuggling. This article specifically narrows down on corruption, an often mentioned yet understudied element of smuggling, and discusses the payment of bribes to border officials, and the creation of riskier routes to facilitate border crossing. We show how unequal access to corruption allow some people smuggling attempts to result in relatively uneventful passages while others are permeated by risks and death. While vilified by governments, corruption is also widely known and accepted as a social equalizer: as a safety valve that allows marginalized Kurds – both kaçakçı and border and security guards – to navigate precarity and survive borderland enforcement regimes. Our analysis from the perspectives of Kurds working as kaçakçı in the context of conflict and internal displacement seeks to move away from the dominant lens used in the analysis of people smuggling, which has almost solely examined it as a form of transnational organized crime and/or as an element of externalised border governance.
The Role of Sexual Consent and Past Non-consensual Sexual Experiences on Rape Supportive Attitudes in a Heterosexual Community Sample
Authors: Rollero Chiara , Moyano Nieves , Roccato Michele
Published: February 2023

The present study aimed to investigate the relationship between (a) sociodemographic variables, past non-consensual experiences and sexual consent and (b) the endorsement of rape supportive attitudes. A sample of 1042 heterosexual adults (42.4% men) was surveyed. A predictive model indicated that the most relevant predictors of rape supportive attitudes were gender (i.e., being male) and most dimensions from sexual consent such as (Lack of) perceived behavioural control, Sexual consent norms, and Awareness and discussion. On the contrary, holding a positive attitude for the establishment of consent in sexual encounters negatively predicted rape supportive attitudes. The positive association between gender (i.e., being male) and (Lack of) perceived behavioural control was stronger among participants who were not victims of past non-consensual sexual experiences than among participants who were victims of past non-consensual sexual experiences, and the same held true when Positive attitude toward establishing sexual consent was involved in the interaction. These findings may help us understand the role of sexual consent on the attitudes that support violence, which can better guide future prevention programs aimed at reducing them.
How negative emotions influence arithmetic performance: a comparison of young and older adults
Authors: Melani Paola , Fabre Ludovic , Lemaire Patrick
Published: February 2023

We investigated the influence of negative emotions on arithmetic problem-solving performance and age-related differences therein. Participants were asked to verify complex multiplication problems that were either true (e.g., 4 × 26 = 104) or false (e.g., 5 × 41 = 201). Half the problems were five problems (e.g., 5 × 28 = 140) and half were non-five problems (e.g., 6 × 36 = 216). False five problems violated the five-rule, the parity-rule, both rules, or no rule. Problems were preceded by emotionally neutral or negative pictures. For true problems, emotions impaired performance while verifying non-five problems in young adults only and while verifying five problems in older adults only. For false five problems, negative emotions influenced young adults’ performance while verifying both-rule and no-rule violation problems but not when verifying parity-rule violation or five-rule violation problems. Negative emotions did not influence older adults’ performance whichever false five problems they solved. These findings suggest that negative emotions may change the mechanisms that participants use to solve arithmetic problems and that emotions influence young and older adults via different mechanisms.
Functional connectivity abnormalities of brain networks in obsessive–compulsive disorder: a systematic review
Authors: Fornaro Silvia , Vallesi Antonino
Published: February 2023

Obsessive-compulsive disorder (OCD) is characterized by cognitive abnormalities encompassing several executive processes. Neuroimaging studies highlight functional abnormalities of executive fronto-parietal network (FPN) and default-mode network (DMN) in OCD patients, as well as of the prefrontal cortex (PFC) more specifically. We aim at assessing the presence of functional connectivity (FC) abnormalities of intrinsic brain networks and PFC in OCD, possibly underlying specific computational impairments and clinical manifestations. A systematic review of resting-state fMRI studies investigating FC was conducted in unmedicated OCD patients by querying three scientific databases (PubMed, Scopus, PsycInfo) up to July 2022 (search terms: “obsessive–compulsive disorder” AND “resting state” AND “fMRI” AND “function* *connect*” AND “task-positive” OR “executive” OR “central executive” OR “executive control” OR “executive-control” OR “cognitive control” OR “attenti*” OR “dorsal attention” OR “ventral attention” OR “frontoparietal” OR “fronto-parietal” OR “default mode” AND “network*” OR “system*”). Collectively, 20 studies were included. A predominantly reduced FC of DMN – often related to increased symptom severity – emerged. Additionally, intra-network FC of FPN was predominantly increased and often positively related to clinical scores. Concerning PFC, a predominant hyper-connectivity of right-sided prefrontal links emerged. Finally, FC of lateral prefrontal areas correlated with specific symptom dimensions. Several sources of heterogeneity in methodology might have affected results in unpredictable ways and were discussed. Such findings might represent endophenotypes of OCD manifestations, possibly reflecting computational impairments and difficulties in engaging in self-referential processes or in disengaging from cognitive control and monitoring processes.
Picard schemes of noncommutative bielliptic surfaces
Authors: Reede Fabian
Published: February 2023

We study the nontrivial elements in the Brauer group of a bielliptic surface and show that they can be realized as Azumaya algebras with a simple structure at the generic point of the surface. We go on to study some properties of the noncommutative Picard scheme associated to such an Azumaya algebra.
Limitations of democratic rights during the Covid-19 pandemic—exploring the citizens’ perception and discussions on dangers to democracy in Germany
Authors: Katsanidou Alexia , Kneuer Marianne , Bensmann Felix , Dimitrov Dimitar , Dietze Stefan
Published: February 2023

The governments’ mitigation measures to fight the COVID-19 pandemic are unprecedented in our post-war history. For overcoming this crisis, citizens were expected to act in compliance with these measures in order to control the spread of the virus and keep public health systems functional. This call for protecting the public health at the same time confronted citizens with several and severe limitations of their democratic freedoms and rights: confinement, restriction on freedoms of movement, religion, specific provisions for public protest and finally also limitations to the right of education by school closures. This paper analyzes how citizens perceive the threat the COVID-19 pandemic and especially the mitigation measures posed for democracy. We assume that pandemic waves and pandemic fatigue have an impact on the perception of threat. To see the overall societal picture, we exploit a large-scale archive of online discourse on Twitter out of which we extract democracy-related discourse with the same temporal and geospatial coverage for our investigation. From that data source, we apply computational methods to extract time series data reflecting aggregated opinions and their evolution over time concerned with the correlation of attitudes towards democracy. We them move deeper using a longitudinal panel survey we conducted in November/December 2020, March/April 2021, and July/August 2021. to have a view of the relationship between citizens’ socio-economic status and basic political attitudes. Our multi-method analysis bases on the German case and covers the period from December 2020 to August 2021.
Photodynamische Therapie – aktuelle Trends
Authors: Harpain L. , Radakovic S.
Published: February 2023

Die photodynamische Therapie (PDT) ist eine minimal-invasive Behandlungsoption, welche auf der dynamischen Wechselwirkung von drei Komponenten basiert, einem Photosensibilisator, Lichtenergie und molekularem Sauerstoff. Das Zusammenspiel dieser Komponenten führt einerseits zur Schädigung bzw. Zerstörung des Zielgewebes, andererseits auch zur Aktivierung von immunmodulierenden Prozessen. Die topische PDT wird sowohl als läsionsgerichtete als auch als feldgerichtete Therapie eingesetzt. In der Dermatologie kommt die topische PDT in der Behandlung aktinischer Keratosen, dem Morbus Bowen und dem Basalzellkarzinom, aber auch off-label bei einer Reihe weiterer Indikationen wie Viruswarzen, Lichtalterung, Akne und Leishmaniose zum Einsatz. Als topische Photosensibilisatoren werden Vorläufer des Häm-Biosynthesewegs, insbesondere 5‑Aminolävulinsäure (5-ALA) oder deren Ester, Methylaminolevulinat (MAL), verwendet. Studien der letzten Jahre deuten darauf hin, dass in der Behandlung oberflächlicher nichtmelanozytärer Hauttumoren der Einsatz von Tageslicht als Lichtquelle (Daylight-PDT) zu vergleichbaren Ergebnissen führt wie die konventionelle PDT unter Anwendung künstlicher Lichtquellen. Im Allgemeinen wird die PDT sehr gut vertragen, die meisten Nebenwirkungen sind vorübergehender Natur und geringfügig, wobei Schmerz während der Behandlung am häufigsten auftritt. Die seit Einführung der topischen PDT anfangs der 1990er Jahre kontinuierlich zunehmende Zahl präklinischer und klinischer Studien haben die PDT mittlerweile als festen Bestanteil der therapeutischen Möglichkeiten in der Dermatologie verankert.
The Inhibition and Variability of Two Different RT-qPCR Assays Used for Quantifying SARS-CoV-2 RNA in Wastewater
Authors: Scott George , Evens Nicholas , Porter Jonathan , Walker David I.
Published: February 2023

Faecal shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its subsequent detection in wastewater turned the spotlight onto wastewater-based epidemiology (WBE) for monitoring the coronavirus-disease 2019 (COVID-19) pandemic. WBE for SARS-CoV-2 has been deployed in 70 countries, providing insights into disease prevalence, forecasting and the spatiotemporal tracking and emergence of SARS-CoV-2 variants. Wastewater, however, is a complex sample matrix containing numerous reverse transcription quantitative PCR (RT-qPCR) inhibitors whose concentration and diversity are influenced by factors including population size, surrounding industry and agriculture and climate. Such differences in the RT-qPCR inhibitor profile are likely to impact the quality of data produced by WBE and potentially produce erroneous results.

To help determine the possible impact of RT-qPCR assay on data quality, two assays employed by different laboratories within the UK’s SARS-CoV-2 wastewater monitoring programme were assessed in the Cefas laboratory in Weymouth, UK. The assays were based on Fast Virus (FV) and qScript (qS) chemistries using the same primers and probes, but at different concentrations and under different cycling conditions. Bovine serum albumin and MgSO4 were also added to the FV assay reaction mixture. Two-hundred and eighty-six samples were analysed, and an external control RNA (EC RNA)-based method was used to measure RT-qPCR inhibition. Compared with qS, FV showed a 40.5% reduction in mean inhibition and a 57.0% reduction in inter-sample inhibition variability. A 4.1-fold increase in SARS-CoV-2 quantification was seen for FV relative to qS; partially due (1.5-fold) to differences in reverse transcription efficiency and the use of a dsDNA standard. Analytical variability was reduced by 51.2% using FV while qS increased the number of SARS-CoV-2 negative samples by 2.6-fold. This study indicates the importance of thorough method optimisation for RT-qPCR-based WBE which should be performed using a selection of samples which are representative of the physiochemical properties of wastewater. Furthermore, RT-qPCR inhibition, analytical variability and reverse transcription efficiency should be key considerations during assay optimisation. A standardised framework for the optimisation and validation of WBE procedures should be formed including concessions for emergency response situations that would allow flexibility in the process to address the difficult balance between the urgency of providing data and the availability of resources.
Schizophrenic Thought Insertion and Self-Experience
Authors: Mathieson Darryl
Published: February 2023

In contemporary philosophy of mind and psychiatry, schizophrenic thought insertion is often used as a validating or invalidating counterexample in various theories about how we experience ourselves. Recent work has taken cases of thought insertion to provide an invalidating counterexample to the Humean denial of self-experience, arguing that deficiencies of agency in thought insertion suggest that we normally experience ourselves as the agent of our thoughts. In this paper, I argue that appealing to a breakdown in the sense of agency to explain thought insertion is problematic, and that rather than following the prevailing binary approach which holds that certain features of consciousness go missing while others remain wholly intact, a better explanation involves construing thought insertion as a disturbing or disrupting of the subjectivity (for-me-ness) of experience. The result is that experiencing ourselves as the subject of our thoughts is where future research should be directed, given the robust persistence of this form of self-experience across psychopathological and non-psychopathological cases alike.
Divide and Rule? Why Ethical Proliferation is not so Wrong for Technology Ethics
Authors: Llorca Albareda Joan , Rueda Jon
Published: February 2023

Although the map of technology ethics is expanding, the growing subdomains within it may raise misgivings. In a recent and very interesting article, Sætra and Danaher have argued that the current dynamic of sub-specialization is harmful to the ethics of technology. In this commentary, we offer three reasons to diminish their concern about ethical proliferation. We argue first that the problem of demarcation is weakened if we attend to other sub-disciplines of technology ethics not mentioned by these authors. We claim secondly that the logic of sub-specializations is less problematic if one does adopt mixed models (combining internalist and externalist approaches) in applied ethics. We finally reject that clarity and distinction are necessary conditions for defining sub-fields within ethics of technology, defending the porosity and constructive nature of ethical disciplines.
Innovative multiple resource recovery pathways from EBPR wastewater treatment–derived sludge
Authors: Binder Pablo M. , Frison Nicola , Guerra-Gorostegi Nagore , Hidayat Ipan , Paredes Lidia , Llenas Laia , Blázquez Enric , Mora Mabel , Ballottari Matteo , Cazzaniga Stefano , Fatone Francesco , Salas Sergio Ponsá
Published: February 2023

Wastewater treatment–derived sludge is a growing concern. Environmental issues, rising sludge production rates, and stringent regulations create the necessity to seek for treatment and valorization alternatives. Sludge is a potential source of high-value materials which can be recovered and transformed into new products such as animal feeds; bioplastics; biofuels, biostimulants; or biobased fertilizers. Considering the current legal constraints hindering the use of certain waste streams, the objective of this work is to show the technical viability for obtaining multiple valuable products from sludge. The emphasis is placed on novel valorization pathways, such as microalgae and purple bacteria cultures growing over sludge. The obtained products are benchmarked against traditional methods for resource recovery such as direct land application and P recovery from ashes. Our results show, besides the nutrient (TKN 7.38, TP 4.41; K 0.47 g 100 g TS-1) and energy content (HHV 22.53 MJ Kg-1 TS), that sludge could be employed to produce a suitable growing medium for microalgae and purple bacteria cultures obtaining, in the latter, remarkable high contents of high-quality proteins (64.50 % dw) for potential valorization as animal feed ingredient. We also obtained nutrient rich microalgae biomass (TKN 7.10, TP 8.10; K 0.40 g 100 g TS-1) which could be used as inputs for biobased fertilizers or biostimulants preliminarily complying with the nutrient requirements in EU 2019/1009. Current global scenario, showing economic and supply risk uncertainties regarding food production inputs, generates the urgent need to find feasible pathways for obtaining recovered products such as the ones presented in this study.

Graphical abstract
On the effects that motivate pesticide use in perspective of designing a cropping system without pesticides but with mineral fertilizer—a review
Authors: Pergner Isabell , Lippert Christian
Published: February 2023

In the future, a cropping system that guarantees food security by delivering high yields and, simultaneously, protects our environment is desperately needed. This can be achieved through a cropping system that waives chemical synthetic plant protection products, which endanger, for example, biodiversity and water resources. However, such a system, referred to here as the mineral-ecological cropping system (MECS), should still allow for the usage of mineral fertilizers to ensure high yields. It can be thought of as a compromise between the current conventional and organic cropping systems. This article presents a comprehensive literature review on the economic, social, and environmental effects of pesticides and the resulting reasons farmers have to use (or not use) them. Hereby, regarding future pesticide reduction, we identify hindrances and potential benefits that could be mobilized to design the MECS. The major points are the following: in a MECS, (1) it is expected that yields and temporal stability of yields will be higher than in organic farming, but lower than in conventional farming; (2) profitability might suffer due to high input costs and energy consumption; (3) it is expected that soil fertility and biodiversity protection will increase along with the promotion of alternative disease and pest control measures; (4) crop rotations will be wider and more diverse than in conventional farming; (5) mineral fertilizer cannot be optimally used by the crops unless a balanced supply of nitrogen is achieved. Farmers who want to switch to MECS should be compensated as they are likely to experience higher costs and lower yield and yield stability. The lessons learned from this review will help to progress toward an innovative and sustainable cropping system. Further research should focus on rational farmers’ adaptation possibilities when abandoning pesticides while still using mineral fertilizers.
Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control
Authors: Xiao Si-Jia , Xu Xi-Ke , Chen Wei , Xin Jia-Yun , Yuan Wen-Lin , Zu Xian-Peng , Shen Yun-Heng
Published: February 2023

Euodiae Fructus, referred to as “Wuzhuyu” in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anti-cardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.
Electronic Monitoring Devices to Support Inhalation Technique in Patients with Asthma: a Narrative Review
Authors: Eikholt Amber A. , Wiertz Mechteld B. R. , Hew Mark , Chan Amy H. Y. , van Boven Job F. M.
Published: February 2023

Purpose of Review

Improper inhaling technique is common and is associated with poor patient outcomes. However, digital e-health devices may offer novel opportunities for educational support. This narrative review provides an overview of electronic monitoring devices (EMDs) measuring patient inhalation technique. We summarise their technical features, capabilities and limitations and discuss the steps necessary for implementation in clinical practice.

Recent Findings

Six EMDs measuring inhalation were identified. The quality of published evidence varied widely. Devices differed in the inhalation technique steps measured, the feedback provided and the type of sensor employed. Sustainability and battery life differed according to whether devices were built into inhalers or add-ons. Nevertheless, all EMDs could reliably capture diverse inhaler technique errors, and some can guide educational interventions and follow-up treatment. In addition, some EMDs may serve as an early warning system for exacerbations.

New-generation EMDs can measure patient inhalation technique, yet there is limited data on patient preferences, acceptability of inhaler technique monitoring, cost-effectiveness and the influence of inhaler technique monitoring on clinical outcomes, all representing areas for further research.
Volatile Lubricants Injected Through Laser Drilled Micro Holes Enable Efficiently Hydrocarbon-Free Lubrication for Deep Drawing Processes
Authors: Reichle Paul , Reichardt Gerd , Henn Manuel , Umlauf Georg , Barz Jakob , Riedmüller Kim Rouven , Liewald Mathias , Tovar Günter E. M.
Published: February 2023

In order to reduce the use of classic lubricants such as synthetic or mineral oils, emulsions or waxes in the deep drawing process, a new tribological system based on volatile lubricants was investigated. In this system, a volatile medium is injected under high pressure through laser drilled micro holes directly into the contact zone between the tool and the sheet metal and serves as a temporary lubricant. In order to investigate this tribological system under realistic conditions, strip drawing experiments with different volatile lubricants (air, nitrogen, carbon dioxide and argon) were performed on galvanized sheets. Therefore, a new generation of strip drawing tools was designed and numerically calculated for low elastic deformations to ensure a uniform contact pressure distribution over the entire friction contact area. To obtain a homogeneous distribution of the volatile lubricants, a number of micro holes with a depth of several millimeters were drilled into the hardened strip drawing jaws using ultrashort pulsed laser radiation. Taking into account the capabilities of this laser drilling technique in terms of size and shape of the micro holes, computational fluid dynamics simulations were performed to predict the flow behavior of the lubricant within the micro hole as well as the contact zone and were compared with observable effects in outflow tests. The chemical composition of the acting tribological layers was characterized by means of X-ray photoelectron spectroscopy and their changes during the deep drawing process were correlated with the lubricants used as well as the measured wear and friction values.
Growth, Yield and Water Productivity of Tomato as Influenced by Deficit Irrigation Water Management
Authors: Mukherjee Sangeeta , Dash Prosanta Kumar , Das Debesh , Das Shimul
Published: February 2023

The deficit irrigation offers water savings potential that is becoming popular in arid and semi-arid regions reducing freshwater use over time. A two-year factorial experiment was conducted to evaluate growth, yield and water productivity of tomato under water deficit irrigation of the drip and furrow method. The experiment was carried out in a split-plot design with drip irrigation and furrow irrigation as main plot treatments, and soil moisture regimes (0, -10, -20, -30 kPa) as subplots. Data were collected on growth parameters, physiological traits, yield and water productivity of tomato. The results showed that physiological traits, yield, and water productivity were significantly influenced by irrigation system and soil moisture regime. The drip irrigation system with -10 kPa soil moisture regime reduced total water input by 22.6% and 19.8% and gave 28% and 22% higher fruit yields in 2020 and 2021, respectively, compared with furrow irrigation system. Plant growth was higher and flowering occurred earlier (3 days) with drip irrigation system than with furrow irrigation. When the soil water content was -10 kPa, drip irrigation performed significantly better than for other soil moisture regimes by improving physiological and phenological attributes, and thereby, advancing tomato growth and fruit yield. Thus, a drip irrigation system with soil moisture regime -10 kPa could reduce total water input through precise irrigation, maximizing tomato yield and water productivity.
The multiple-level framework of developmental dyslexia: the long trace from a neurodevelopmental deficit to an impaired cultural technique
Authors: Lachmann Thomas , Bergström Kirstin
Published: February 2023

Developmental dyslexia is a neurodevelopmental disorder characterized by an unexpected impairment in literacy acquisition leading to specific poor academic achievement and possible secondary symptoms. The multi-level framework of developmental dyslexia considers five levels of a causal pathway on which a given genotype is expressed and hierarchically transmitted from one level to the next under the increasing influence of individual learning-relevant traits and environmental factors moderated by cultural conditions. These levels are the neurobiological, the information processing and the skill level (prerequisites and acquisition of literacy skills), the academic achievement level and the level of secondary effects. Various risk factors are present at each level within the assumed causal pathway and can increase the likelihood of exhibiting developmental dyslexia. Transition from one level to the next is neither unidirectional nor inevitable. This fact has direct implications for prevention and intervention which can mitigate transitions from one level to the next. In this paper, various evidence-based theories and findings regarding deficits at different levels are placed in the proposed framework. In addition, the moderating effect of cultural impact at and between information processing and skill levels are further elaborated based on a review of findings regarding influences of different writing systems and orthographies. These differences impose culture-specific demands for literacy-specific cognitive procedures, influencing both literacy acquisition and the manifestation of developmental dyslexia.
Geriatric rehabilitation care after hip fracture
Authors: Mattiazzo G. F. , Drewes Y. M. , van Eijk M. , Achterberg W. P.
Published: February 2023

Purpose

After acute hospital admission, patients with a hip fracture are frequently discharged to skilled nursing homes providing geriatric rehabilitation (GR). There are few evidence-based studies regarding specific treatment times and assessments during GR. This study aims to provide a description of care for hip fracture patients during GR in the Netherlands.

Methods

Descriptive study analyzing the care pathways from GR facilities, regarding healthcare professionals involved, allocated treatment time per profession, total length of rehabilitation stay, and assessment instruments. Based on the reimbursement algorithm (diagnostic treatment combination = DBCs), of 25 patients, the registered actual treatment time per profession was calculated.

Results

The care pathways pivoted on three groups of health care professionals: medical team (MT), physiotherapy (PT), and occupational therapy (OT). There was some discrepancy between the allocated time in the care pathways and the calculated mean actual treatment time from the DBCs. First week: MT 120–180 min, DBC 120 (SD: 59) minutes; PT 120–230 min, DBC 129 (SD: 58) minutes; and OT 65–165 min, DBC 93 (SD: 61) minutes. From week two onwards, MT 15–36 min, DBC 49 (SD: 29) minutes; PT 74–179 min, DBC 125 (SD: 50) minutes; and OT 25–60 min, DBC 47 (SD: 44) minutes. Dieticians, psychologists, and social workers were sporadically mentioned. There was heterogeneity in the assessment and screening tools.

Conclusions

It is difficult to define current standard care in GR after hip fracture in the Netherlands due to the diversity in care pathways and large practice variation. This is a problem in conducting randomized effectiveness research with care provided as control.

Trial register and date of registration

NL7491 04-02-2019.
Research on auxiliary training system of oral English pronunciation based on data extraction
Authors: Qin Xiaomei
Published: February 2023

Due to the limitations of the language environment and other aspects, students generally have problems such as inaccurate English pronunciation in oral English learning. To solve the English pronunciation problem, an English oral pronunciation auxiliary training system based on data extraction is designed. With the help of the B/S three-tier structure, the system designs the overall framework of the system, including the data layer, business logic layer, and display layer. In the hardware design of the system, the collection, transmission, and processing of oral English pronunciation audio are realized with the help of pickup, audio Bluetooth chip, and programmable logic controller. Three business processing programs are designed, including a pronunciation audio input processing program, pronunciation audio data extraction program, and pronunciation auxiliary training program, to correct oral English pronunciation. The experimental results show that the system can improve students' oral English pronunciation and improve students' oral learning performance.
A novel strategy for a reinforced anammox process with iron-modified Enteromorpha prolifera biochar
Authors: Xu Ao , Tian Yuan , Chen Guanghui , Gao Dawen , Yu Deshuang , Liang Hong , Wang Yanyan , Zhang Qiang
Published: February 2023

Modified biochar with higher electron transport and adsorption capabilities could significantly improve the performance of anaerobic ammonia oxidation (anammox). However, there are few related investigations on the reinforcement of anammox through iron-modified Enteromorpha prolifera biochar (IMEPB). In this study, with the addition of the IMEPB in the anammox system, the enhancing process of anammox performance was studied, the improving feasibility of anammox was evaluated, and the reinforcing mechanism of anammox was elucidated. The results showed that the optimal iron−charcoal ratio (Fe:C) and IMEPB dosage were 1:10 and 10 g L−1, respectively. Under the optimal conditions, when the nitrogen loading rate gradually increased to 0.557 (kg m−3 day−1), the nitrogen removal efficiency and nitrogen removal rate of the anammox process supplemented with IMEPB increased by 11%, and the specific anammox activity increased by 23.8%. Compared with the control, the secretion of extracellular polymeric substances (EPS) of anammox bacteria supplemented IMEPB increased by 24.4%, greatly improving the stability of the anammox system. Meanwhile, EPS secretion further promoted the microbial activity of anammox bacteria, achieving a 19% increase in the abundance of Candidatus Brocadia. These findings demonstrate the potential mechanism of IMEPB in improving anammox, provide new insights into recycling E. prolifera, and provide a novel reinforcement strategy for anammox. In the future, adding IMEPB may be a vital measure for the practical application of anammox in coastal areas.

Graphical Abstract
Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons
Authors: Pasierski Michał , Kołba Weronika , Szulczyk Bartłomiej
Published: February 2023

Background

Guanfacine (an alpha-2A receptor agonist) is a commonly used drug with recognized efficacy in the treatment of attention deficit hyperactivity disorder (ADHD). This study aimed to assess the effects of guanfacine on short-lasting (interictal) epileptiform discharges in cortical neurons. Moreover, we assessed the effects of guanfacine on voltage-gated sodium currents.

Methods

We conducted patch-clamp recordings in prefrontal cortex pyramidal neurons obtained from young rats. Interictal epileptiform events were evoked in cortical slices in a zero magnesium proepileptic extracellular solution with an elevated concentration of potassium ions.

Results

Interictal epileptiform discharges were spontaneous depolarisations, which triggered action potentials. Guanfacine (10 and 100 µM) inhibited the frequency of epileptiform discharges. The effect of guanfacine on interictal events persisted in the presence of alpha-2 adrenergic receptor antagonist idazoxan. The tested drug inhibited neuronal excitability. Tonic NMDA currents were not influenced by guanfacine. Recordings from dispersed neurons showed that the tested drug (10 and 100 µM) inhibited persistent and fast inactivating voltage-gated sodium currents.

Conclusions

This study shows that guanfacine inhibits interictal discharges in cortical neurons independently of alpha-2A adrenergic receptors. This effect may be mediated by voltage-gated sodium currents. Inhibition of interictal activity by guanfacine may be of clinical importance because interictal events often occur in patients with ADHD and may contribute to symptoms of this disease.

Graphical abstract