bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-Contact Co-Design: Considering more flexible spatiotemporal models for the co-design workshop
Authors: Davis Aaron , Gwilt Ian , Wallace Niki , Langley Joe
Published: June 2021

The recent global experience of COVID-19 has problematized the face-to-face co-design process and forced co-design researchers and practitioners to rethink the process of collaboration that typically takes place in a co-design workshop. This paper considers how we might continue to co-design when physical proximity is not possible. Recognising that technology has long played a role in co-design practice, we argue that to date, the technologically mediated experience of co-design has been largely based on the assumption of replicating the physical and embodied experience of the co-design workshop. Rather than accepting the deficit culture implied through the curtailing of much of the conventional face-to-face activities we associate with co-design, this paper reports on proactive research into novel possibilities for continuing collaborative research work through the concept of ‘low-contact co-design’. A series of proprietary visual models that explore a range of spatiotemporal conditions within which co-design practices can occur are presented. Opportunities for engaging with new communities, and in new processes are highlighted and a spatiotemporal framework for planning co-design processes is presented.
‘Breathful’ design in breathless times
Authors: Wernli Markus , Boyer Britta
Published: June 2021

This position paper seeks to address the operational logic that created the conditions for the pandemic to take hold. Grasping the crisis as an opportunity for an anthropological inquiry across disciplines, this exploration firmly anchors design inside the social commitment required by breathing bodies and life-enabling atmospheres. By infusing the self-understanding of design with experiences and conceptions from Eastern and Western ‘breathwork’ practices the adaptation strategy in uncertainty shifts from perpetuating the status quo towards the creative reinterpretation of internal priorities. It also changes the nature of our projects, from making to enacting, from preprogrammed solutions to earthly engagement, from interfacing with inert matter to caring for living matters. Taking our universally shared breath as the resounding call for action, ‘breathful’ design is about the never-finished, perpetually opening task of persisting through bodily vigilance, diligence, and self-critical forsight for ‘knowing what to do when no one knows what to do’.
Design during COVID-19: agents and allies in the role of designer, digital fabrication and distributed production
Authors: Herrera Pablo C. , Dreifuss-Serrano Cristina , Juarez Benito
Published: June 2021

During COVID-19 global emergency, designers proposed solutions at different scales, as quick responses to demands from different agents. In the same way, we critically analyzed the emergence of allies, protocols and tools, which allowed the optimization of fabrication, from traditional manufacturing into distributed co-production. The analyzed local networks produced global co-design experiences, with involvement of FabLabs and users from different disciplines. Through case studies and the evaluation of surveys and testimonials from users and makers, we analyze the global panorama, to finally explore the specific situation in Latin America. This establishes a relationship between medical demand and digital fabrication, which allows evidence of positive and negative situations to be consider as new, significant aspects for the design in the future. The leading role acquired by the ecosystem surrounding digital fabrication during the pandemic, could enhance its processes in the search for greater positioning, changing society from within the different communities.
Data visualization in the time of coronavirus
Authors: Rabetti Giannella Júlia , Velho Luiz
Published: June 2021

Currently, we observe a proliferation of data visualizations about Covid-19 in the media, which makes it a convenient time to study the topic from the perspective of different disciplines, including information design and mathematics. If, on the one hand, the abundance of such pandemic representations would already be a legitimate reason to address the issue, on the other hand, it is not the central motivation of the present discussion. The uniqueness of the epidemiological phenomenon that we are experiencing highlights new aspects regarding the production and use of data visualizations, one of which is its diversification beyond counting and visual representation of events related to the virus spread. In this sense, the article discusses, through the analysis of examples, three different approaches for this type of schematic representation, namely: visualization of hypothetical data, visualizations based on secondary data, and visualization for social criticism and self-reflection. Ultimately, we can argue that design contributes to the production of data visualizations that can help people to understand the causes and implications involved in the new coronavirus and encourage civic responsibility through self-care and the practice of social distancing.
Tactical Acts from Lockdown Homes
Authors: Acharya Karthikeya , Pop Madalina
Published: June 2021

The COVID 19 lockdown brought work home. As design researchers our interest has been in the socio-material changes which the pandemic lockdown, as a top down strategy has brought to the domestic realm. Using an online response gathering tool we undertook an inquiry with 31 different households from around the world. Analyzing this data, we present 7 inter-connected activity categories performed by people as they merged and separated their professional work and domestic living within their homes. From within these categories we note particular activities let people overcome the pressures of merging professional work and domestic living. We see these activities to be tactically emerging from specific characteristics of the domestic realm. Targeting innovation specialists, product designers, architects and service designers we seek the potential for amplifying such tactical characteristics when designing for working from home futures.
Aligning and Assessing Teaching Approaches With SOLO Taxonomy in a Computer Programming Course
Authors: Malik Sohail Iqbal , Tawafak Ragad M. , Shakir Mohanaad
Published: June 2021

A teaching approach plays an important role in teaching and learning process of an introductory programming (IP) course. The teaching approach should focus on different programming skills required by novice programmers. In this study, we introduced the teaching and learning approach based on an ADRI (Approach, Deployment, Result, Improvement) approach in the IP course which focuses on both programming knowledge (syntax and semantics) and problem solving strategies. We compared the teaching and learning approach of the IP course with the five levels of SOLO taxonomy. We assessed the students’ performance by using different assessment tasks based on the four stages of the ADRI approach. Results show that the current teaching and learning approach of the IP course addressed all the five levels of SOLO taxonomy. The students’ performance in the Approach and Result stages (82%) are good, and the performance in the Improvement (71%) and Deployment (69%) stages are satisfactory. Overall, the ADRI approach provides positive impact on the teaching and learning process of the IP course.
Influential Indicators and Measurements of Mediating and Moderating Roles on SME Performance
Authors: Kim Seok-Soo
Published: June 2021

Overcoming the failure of SMEs has been an important research topic. The critical research finding is that it has verified the essential elements of performance improvement. We presented a solution to the research question, "Is there a causal relationship between the effect on SMEs' success on capacity and business performance?". We analyzed whether the competence of SMEs had a mediating effect between success variables and performance. Secondary effects were empirically studied by converting independent variables to Higher-Order Component (HOC). The second-order variable of management influenced financial, non-financial, and technical performance, and the second-order variable of technology affected technical performance. As a result of introducing demographic variables as a controlling variable for performance, gender, and year of establishment showed a moderating effect on technical and non-financial performance. We expect to contribute to practical application to SME CEOs and government policymakers, support organizations, academia, and industry.
A Flipped Instructional Design as an Online Pedagogy Enabling Student Learning in an ODeL Course
Authors: van Wyk Micheal M.
Published: June 2021

The growing body of literature is reporting positive results when it comes to flipped learning which across disciplines and contexts involves student-centered, technology-integrated teaching. Using a systematic scoping review, this paper seeks to examine the impact of the flipped instructional design (FID) as an online pedagogy on students’ learning. This paper employed a pragmatic approach, an explanatory mixed-methods design. This paper concluded that the flipped instructional design does engage students’ learning and empowers them in terms of modeling to teach during the course. Undeniably, this scholarly endeavor revealed that benefits outweighed drawbacks regarding the functionality, usefulness, personalized learning outcomes, freeing-up-time, collaboration, and active participation towards self-directed learning. The flipped instructional design strategy was used as reliable, relevant and appropriate to search scholarly works systematically, but more research needs to be conducted for an ODeL environment.
Two adventive species of European Chrysomelidae (Coleoptera) new to North America:Cryptocephalus moraei(Cryptocephalinae) andPsylliodes dulcamarae(Galerucinae: Alticini), and the origins of adventive Chrysomelidae in Canada and United States of America
Authors: Douglas Hume B. , Dumont Stéphane , Savard Karine , Chantal Claude
Published: June 2021

First North American records are presented forCryptocephalus moraei(Linnaeus, 1758) (Coleoptera: Cryptocephalinae) andPsylliodes dulcamarae(Koch, 1803) (Coleoptera: Galerucinae: Alticini), as confirmed by morphology and DNA barcoding. Additional information is presented about phenology and host use forC. moraei, the first European Cryptocephalinae to be found elsewhere as conclusively adventive.Cryptocephalus moraeiis expected to have no ecological impact on its host, the adventiveHypericum perforatumLinnaeus (Hypericaceae). However,P. dulcamarae,the second recently discovered flea beetle associated with the adventiveSolanum dulcamaraLinnaeus (Solanaceae), probably does harm that host. Both species are hypothesised to have arrived from Europe with woody plant material imported with soil during 1960–1965. A literature review of introduced Chrysomelidae found that Canada and the United States of America are together home to 68–78 species of adventive Chrysomelidae. All non-Bruchinae species among these are both native to Europe and occur either in Canada or both Canada and United States of America, except for intentionally introduced biological control agents and two species that feed onEucalyptusL’Héritier de Brutelle (Myrtaceae). This suggests a dominant role of accidental introductions of cool-climate European species in recent unplanned additions to the fauna of leaf-feeding Chrysomelidae in North America.
Specific COVID-19 Symptoms Correlate with High Antibody Levels against SARS-CoV-2
Authors: Amjadi Maya F , O’Connell Sarah E , Armbrust Tammy , Mergaert Aisha M , Narpala Sandeep R , Halfmann Peter J , Bashar S Janna , Glover Christopher R , Heffron Anna S , Taylor Alison , Flach Britta , O’Connor David H , Kawaoka Yoshihiro , McDermott Adrian B , Sethi Ajay K , Shelef Miriam A
Published: June 2021

Lasting immunity will be critical for overcoming COVID-19. However, the factors associated with the development of high titers of anti–SARS-CoV-2 Abs and how long those Abs persist remain incompletely defined. In particular, an understanding of the relationship between COVID-19 symptoms and anti–SARS-CoV-2 Abs is limited. To address these unknowns, we quantified serum anti–SARS- CoV-2 Abs in clinically diverse COVID-19 convalescent human subjects 5 wk (n = 113) and 3 mo (n = 79) after symptom resolution with three methods: a novel multiplex assay to quantify IgG against four SARS-CoV-2 Ags, a new SARS-CoV-2 receptor binding domain-angiotensin converting enzyme 2 inhibition assay, and a SARS-CoV-2 neutralizing assay. We then identified clinical and demographic factors, including never-before-assessed COVID-19 symptoms, that consistently correlate with high anti–SARS-CoV-2 Ab levels. We detected anti–SARS-CoV-2 Abs in 98% of COVID-19 convalescent subjects 5 wk after symptom resolution, and Ab levels did not decline at 3 mo. Greater disease severity, older age, male sex, higher body mass index, and higher Charlson Comorbidity Index score correlated with increased anti–SARS-CoV-2 Ab levels. Moreover, we report for the first time (to our knowledge) that COVID-19 symptoms, most consistently fever, body aches, and low appetite, correlate with higher anti–SARS-CoV-2 Ab levels. Our results provide robust and new insights into the development and persistence of anti–SARS-CoV-2 Abs.
Practical issues and research trends of oncofertility in gynecologic cancer
Authors: Park Jeong-Yeol
Published: June 2021

In recent years, there has been a greater impetus toward preserving fertility in young women with gynecologic cancer. This is related to the increasing incidence of gynecologic cancer in young women and to the social phenomenon in which women, on average, are getting married and having their first child at an older age. For women with early gynecologic cancer, treatment strategies can be undertaken to preserve the uterus and part of the ovaries, which can be used to preserve fertility. For women with advanced gynecologic cancer, treatment strategies using assisted reproductive technology are the main option to preserve fertility. Young women with gynecologic cancer who want to preserve fertility should be counseled thoroughly regarding treatment options that allow fertility preservation before commencing anti-cancer treatment. This article describes various methods for preserving fertility and examines recent research trends related to young women with gynecologic cancer.
Observational Study on Healthcare Workers Protection in the Angiographic Suite during the Sars-COV-2 Pandemic: Before and during Vax Era
Authors: Cernigliaro Massimiliano , Negroni Davide , Sassone Miriana , Paladini Andrea , Carriero Alessandro , Saba Luca , Guzzardi Giuseppe
Published: June 2021

Background

Since the first case of Coronavirus Disease 2019 (COVID-19) in Italy, all the hospital facilities had to reform their daily activities. Amidst them, the Interventional Radiology Department in the “Azienda Ospedaliera Universitaria” of Novara (Italy) had to create a dedicated protocol for the patent's management during the pandemic.

Design and methods

The time interval between February 2020 and March 2021 was divided into three different periods and we reported the evolution of our safety protocol, the changes in our daily activities and the rates of SARS-CoV-2 infection among the healthcare workers (HCW) of the Angiographic Suite. Personnel who had positive partners/family members or who had established close contacts of another nature outside the workplace were excluded from the study, in order to reduce any bias.

Results

A total of 35 HCWs served in 355 patient procedures on SARS-CoV-2 positive patients from February 2020 to March 2021. During the year there was a reduction in the morbidity rate first from 7.9% to 1.4% and then currently reaching 0%.

Conclusions

Dedicated routes, elevators, establishing filter areas and a clear demarcation between clean and contaminated areas, dressing and undressing procedures, cleaning procedures and the obligation to always wear a surgical mask during the working shift are essential to prevent in-hospital infection. The vaccines’ arrival seems to further reduce the risk for healthcare workers, but it is still necessary to take docile precautions in view of the new mutations of the virus.
Ointment therapy and prevention of cannulation-induced superficial phlebitis
Authors: Raziani Yosra , Othman Brwa Salah
Published: June 2021

The primary aim of this prospective randomized trial is to determine the effect of clobetasol ointment with nitroglycerin ointment on the prevention of phlebitis caused by cannulation. The target sample is 144 patients admitted to surgical ward, randomized to 3 groups. the data collection tools included demographic information, information about intravenous treatment and phlebitis measurement scale. In the intervention groups, after venipuncture, 1.5 cm of ointments (clobetasol and nitroglycerin) was applied n three time periods of 24, 48 and 72 hours from the time of venipuncture. In the first 24 hours after cannulation, there was no significant difference between the three groups. But at 48 and 72 hours after placement, the difference between intervention and control groups was significant (P<0.0001). It is recommended to use clobetasol ointment and nitroglycerin ointment to prevent the occurrence of phlebitis in patients who need long-term use of cannula (more than 48 hours).
Medication Adherence in Indian Epilepsy Patients
Authors: Kumar Shrawan , Singh Mamta Bhushan , Kumar Amit , Padma Srivastava M V , Goyal Vinay
Published: June 2021

Purpose:

While two-thirds of epilepsy patients can become seizure free on medical treatment, poor adherence to medication is a major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated factors of antiepileptic drug (AED) non-adherence.

Methods:

We conducted a subgroup analysis based on results that emerged from a single center, cross-sectional study. Patients who were 18 years or older were included. The 4-item Morisky Medication Adherence Scale was used to measure adherence to AED (s). Multivariable logistic regression analysis was used to predict factors associated with AED non-adherence.

Results:

A total of 268 patients fulfilled inclusion criteria and were included in this subgroup analysis. Among the participants, 81 (30%) were non-adherent to medication. Three factors associated with non-adherence were AED polytherapy [OR: 4.5 (2.1-9.5) P = 0.001], drug related adverse events [OR: 3.9 (2.1-7.3) P = 0.001], and treatment duration exceeding 3 years [OR: 2.6 (1.3-5.0) P = 0.003].

Conclusion:

About one-third patients were not compliant with their medication. If the treatment of patients is restricted to monotherapy as far as possible and patients are educated about duration of treatment and possible adverse effects of AEDs, non-adherence may be reduced.
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
Authors: Zhou Hua , Wu Shunhong , Tang Xiaohua , Zhou Guanqing , Yuan Jingru , Li Qing , Chen Yaoyong , Xu Xia , Sun Xiaofang , Zhu Detu , Luo Yumei
Published: June 2021

Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlike that in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective study was to explore the impacts of CT infection in the genital tract on sperm quality, sperm acrosin activity, antisperm antibody levels, and inflammation in a large cohort of infertile males in China. A total of 7154 semen samples were collected from infertile male subjects, 416 of whom were CT positive (CT+ group) and 6738 of whom were CT negative (CT− group), in our hospital between January 2016 and December 2018. Routine semen parameters (semen volume, pH, sperm concentration, viability, motility, morphology, etc.), granulocyte elastase levels, antisperm antibody levels, and sperm acrosin activity were compared between the CT+ and CT− groups. Our results showed that CT infection was significantly correlated with an abnormally low semen volume, as well as an increased white blood cell count and granulocyte elastase level (all P < 0.05) in the semen of infertile males; other routine semen parameters were not negatively impacted. The antisperm antibody level and sperm acrosin activity were not affected by CT infection. These findings suggested that CT infection might contribute to inflammation and hypospermia but does not impair sperm viability, motility morphology, and acrosin activity or generate antisperm antibodies in the infertile males of China.
Acute Liver Failure in a Patient with Thyroid Storm and Hepatitis E Infection
Authors: Sharma Vivek Mohan , Mathur Amit , Saxena Kandarp , Singh Arun
Published: June 2021

Hepatic dysfunction with thyroid storm presents a diagnostic challenge. A young male presented with symptoms suggestive of acute liver failure (ALF). Examination revealed bilaterally enlarged thyroid gland. Viral marker was positive for immunoglobulin M anti-hepatitis E virus. Thyroid profile revealed suppressed thyroid-stimulating hormone and raised T3 and T4. Working diagnosis of ALF due to viral hepatitis E and thyroid storm was made. The patient was stabilized with Lugol's iodine and lithium, after which he underwent total thyroidectomy. Postsurgery patient had significant clinical improvement and was put on oral thyroxine. He achieved normal liver function on subsequent follow-ups.
A Novel “BISSHOAP” Score for Predicting Severe and Moderately Severe Acute Pancreatitis in Emergency Room
Authors: Zanwar Shankar , Mohan Arumugam T. , Paramsivan Piramanayagam , Parmeswaran Sarojini Ashok , Srinivas Usha , Mutthuswamy Hariharan , Dhus Ubal , Venkatesh Seshadri , Mahalingam Preethi , Ramasamy Palanisamy Kallipatti , Nayak Sathish , Parikh Pallav
Published: June 2021

Background:

The existing scores for predicting severity of acute pancreatitis (AP) underperform in sensitivity. The existing scores do not predict moderately severe pancreatitis.

Methods:

We performed a prospective observational study from August 2014 to April 2016 on patients hospitalized at Apollo Hospitals, Chennai, with a clinical diagnosis of AP (as per Atlanta 2012 classification). Three established scoring systems – Complete Ranson's (at 48 h), Acute Physiology and Chronic Health Evaluation (APACHE-II), Bedside Index of Severity in AP (BISAP) and new score BISAP + saturation of oxygen, hematocrit (BISAP + SHO) (packed cell volume [PCV]) and overweight by body mass index [BMI]) were calculated at admission. In BISAP + SHO score 5 points were given as in BISAP and 3 points were added 1 each for low oxygen saturation ≤92%, PCV ≥47% and BMI of ≥23 making BISAP + SHO an 8-point score. The prediction by scores was validated against the actual clinical outcome of severity.

Results:

Of 102 patients with AP, 34 (33%) patients had organ failure (OF) and in 17 patients (16.5%) it lasted >48 h, classified as severe AP. Remaining 17 were moderately severe AP as OF resolved within <48 h. Cut-off values to predict severe pancreatitis were - Ranson's score - ≥3, APACHE-II - ≥8, BISAP - ≥3, and BISAP + SHO - ≥5. Area under receiver operator curve (AUC) for Ranson's, APACHE-II, BISAP and BISAP + SHO were 0.958, 0.953, 0.899 and 0.989, respectively. With a score 3 or 4, BISAP + SHO predicted moderately severe AP with a sensitivity of 94.12%, specificity 97.6%.

Conclusions:

The BISAP + SHO (rephrased as BISSHOAP) stratifies AP with better AUC than existing scores and is also able to predict moderately severe pancreatitis in the ER.
Immunosuppression
Authors: Raju Swati , Jain Mayank , Varanasi Bhargav Yugandar , Selvan Thamarai S. , Venkataraman Jayanthi
Published: June 2021

Immunosuppression in immediate post liver transplantation (LT) setting is crucial to prevent rejection. Most immunosuppressant (IS) drugs have several adverse effects, necessitating dose adjustment, close monitoring of blood levels, and choosing the right drug on a case-to-case basis so as to achieve optimal immunosuppression with minimal side effects. Although guidelines are available for management, the IS regimen differs from center to center, especially with introduction of new agents. The calcineurin inhibitors (CNIs) are the most important class of IS regimen. However, the occurrence of major adverse effects with CNIs has necessitated the need for alternative drugs such as mammalian target of rapamycin inhibitors and antibody induction therapies. Early rejection episode management, especially within the first 3 months after LT, needs special consideration. The present review will highlight the current strategies in induction and maintenance of LT recipients in the immediate post-LT period and in a selective special situation.
Cost-Effectiveness Analysis of Head Computed Tomography in Children with Mild Traumatic Brain Injury
Authors: Tunthanathip Thara , Phuenpathom Nakornchai , Sae-heng Sakchai , Oearsakul Thakul , Sakarunchai Ittichai , Krewborisutsakul Anukoon , Taweesomboonyat Chin
Published: June 2021

Background:

Head computed tomography (CT) is used as a diagnostic tool for intracranial injury following traumatic brain injury (TBI). However, the long-term effects of radiation exposure should be of concern in children. This study compared the cost-effectiveness of the early head CT (ECT) strategy with that of initial conservative treatment with parent education of the nonearly CT (NECT) in pediatric TBI with a Glasgow Coma Scale (GCS) score of 15.

Methods:

A retrospective study was conducted with TBI children with a GCS of 15, who were treated at an emergency department (ED). The costs and outcomes of the children were recorded. The authors used a decision tree model (Plant-A-Tree, International Decision Support Initiative, United Kingdom) to compare the cost-effectiveness analysis of two strategies. The incremental cost-effectiveness ratio (ICER) was also calculated.

Results:

For the ECT group, the rate of the positive results following head CT was 17.6%, and the common intracranial injuries were epidural hematoma, skull fracture, and subdural hematoma in 11.5%, 9.8%, and 6.6%, respectively. The children in the ECT group who underwent surgery were 3.2%. For the NECT group, revisions were observed in 5.3%, and all patients with revision underwent CT. Therefore, the frontal contusion was observed in 10% following CT, and none underwent surgery in the NECT group. From a healthcare provider’s perspective, the expected cost of the ECT group was US $597.49, whereas the expected cost of the NECT group that included overall costs at ED was US $115.27. The expected outcome of the ECT group was less than the NECT group that caused the base-case ICER to be negative (−US $30,715.28 per outcome gained). A sensitivity analysis revealed that an early CT strategy became a dominant strategy that needed a low revision rate but a high rate of positive findings after head CT.

Conclusion:

The initial conservative treatment was the dominant strategy. This strategy was safe and effective and could diminish the unnecessary exposure to radiation in children.
COVID-19 and manifest psychological morbidity
Authors: Kumar Parmod , Kamal Shubham , Tuli Shubhangi , Gupta Nitin
Published: June 2021

The COVID-19 pandemic in India has been reported to be associated with numerous major mental health issues globally; the most common is – stress, anxiety, depressive symptoms, insomnia, denial, anger, and fear. This case series presents three different cases, wherein the COVID-19 pandemic resulted not only in deterioration of previous symptoms experienced by patients (obsessive–compulsive disorder and depression) but also led to the development of new symptoms specifically related to coronavirus (Psychosis). Authors highlight the need to develop preventive strategies for vulnerable groups and try to understand the etiopathogenesis of illnesses so developing, in order to identify support systems and management strategies during the pandemicrelated crisis.
A study to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors and serotonin dopamine antagonists
Authors: Tomar Love Kumar , Patra Priyadarshee , Nigam Ankur
Published: June 2021

Introduction:

Hyponatremia can be a common but often overlooked side effects of psychotropics drugs. Most patients with drug-induced hyponatremia are asymptomatic and diagnosis is made incidentally following routine blood tests.

Objectives:

The aim of the study was to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors (SSRI) and serotonin dopamine antagonists (SDA).

Materials and Methods:

All inpatients and outpatients who were diagnosed with International Classification of Diseases-10 psychiatric disorders and undergoing treatment with SSRI, SDA, or combination of both for the same, were included in the study after simple random sampling, subject to inclusion and exclusion criteria.

Statistical Analysis Used:

Categorical variables were observed as numbers and percentages. Continuous variables were evaluated as mean ± standard deviation. A Chi-square test was done to find the association between categorical variables. SPSS (IBM) version 21 was used for data analysis.

Results:

In 150 patients, we found hyponatremia in 17 patients (11.33%). About 66–75 age group patients had maximum found cases of hyponatremia (66.66%). About 20.31% of females found hyponatremia. Among SSRIs, 16% of individuals had hyponatremia whereas among SDA it was 6%. Patients who were taking both SSRIs and SDA total prevalence of hyponatremia was 12%.

Conclusions:

Older age groups and females had higher chances of hyponatremia while taking SSRIs and SDAs. Among SSRIs, escitalopram had maximum percentage of hyponatremia, whereas fluvoxamine had minimum. Among SDAs, risperidone had maximum percentage, whereas quetiapine had minimum percentage of hyponatremia. Patients who were taking both fluoxetine + olanzapine or fluoxetine + risperidone had higher percentage of hyponatremia.
Coping strategies and social support as moderators of occupational stress and mental health link among police personnel
Authors: Singh Shweta , Gupta Bandna , Mishra P. C.
Published: June 2021

Background:

The occupation of police personnel is known to be enormously stressful. The occupational stress research shows that coping strategies and social support have a buffering effect on stress and a protective role on mental health. The present research study was set out to investigate the role of coping strategies and social support as moderating factors of the relationship between occupational stress and mental health in police personnel of Uttar Pradesh in terms of their ranking.

Methodology:

The present cross-sectional study was conducted using standardized questionnaires. The sample comprised a total of 300 male police personnel. Hundred constables, 100 inspectors, and 100 officers were incidentally selected from six districts of Uttar: Lucknow, Varanasi, Meerut, Raebareli, Ghaziabad, and Noida.

Results:

Study results showed coping strategies and social support to have a moderating effect on the relationship between stress and mental health in inspectors and officers but failed to show such relationship in constables.

Conclusion:

There is the implication for the training in terms of teaching-specific active and adaptive coping strategies for the management of workplace-related stress and promotion of health and well-being in the police personnel.
Management of obsessive–compulsive disorder with virtual reality-based exposure
Authors: Dua Devakshi , Jagota Gopika , Grover Sandeep
Published: June 2021

Little information is available about use of virtual reality exposure for management of obsessive compulsive disorder (OCD). We present a patient with OCD, who presented with significant dysfunction related to his OC symptoms and was managed with virtual reality based exposure therapy. A 27-year-old male, presented with a history suggestive of OCD for last 8 years. His symptoms were characterized by obsessive images of known people, leading to significant anxiety and distress. To get rid of his anxiety and distress, he would repeat the acts at hand, multiple times till these images would subside or till he would be able to replace these images by desirable images. These symptoms led to marked socio-occupational dysfunction. The treatment history was suggestive of minimal response to adequate trials of multiple selective serotonin reuptake inhibitors and he was on capsule fluoxetine 80 mg/day at the time of presentation. Exposure and Response therapy was tried in the past by using imaginal exposure, but this was unsuccessful, as the patient would avoid imagining the anxiety-provoking images. Hence, he was exposed to the anxiety provoking images by using virtual reality which involved presenting him with videos containing pictures of known and unknown people arranged randomly, along with the anxiety-provoking images. Over a period of 2 months, 60 sessions of ERP were carried out and the whole hierarchy was completed. This case demonstrates that virtual reality can be used in behaviour therapy for OCD, by using virtual reality techniques, and there is a need to develop software and programs for assessment and management of OCD.
A Study on the Cardiac Manifestations and their Short-Term Outcome in Patients with Kawasaki Disease in an Indian Population
Authors: Rajesh Gopalan Nair , Prasanth S , Vellani Haridasan , Jose Jomy Vadasseril
Published: June 2021

Objectives:

This study aimed to assess the prevalence of cardiac manifestations and their short-term outcome in patients with Kawasaki disease (KD) in an Indian population.

Methods:

This single-center prospective study enrolled a total of 56 consecutive patients with classic and incomplete KD. Six months and 1-year clinical outcomes were analyzed.

Results:

Fifty-six consecutive patients were enrolled in the study and followed up for 1 year. About 87% completed 6 months follow-up. A diagnosis of complete KD was made in 41 (73%) patients and incomplete KD in 15 (27%). Cardiac manifestations were present in 25% of patients with KD. Coronary involvement was observed in 11 (20%) patients by either Japanese Ministry of Health Criteria or a z score of ≥2.5. Nonpurulent conjunctivitis was significantly higher among children with cardiac involvement (79% vs. 43% P= 0.04). The mean value of erythrocyte sedimentation rate (ESR) was significantly higher among patients with cardiac involvement (101.92 ± 22 vs. 74.26 ± 28.6; P= 0.002). An ESR value of >100 mm/hr was predictive of cardiac involvement (P = 0.03). The mean serum glutamic-pyruvic transaminase value was higher among those with cardiac involvement (P = 0.008). Coronary dilatation got resolved in 3 months in 73% of patients. Valvular regurgitations, aortic root involvement, and depressed left ventricular myocardial function were not observed in the population studied.

Conclusions:

Cardiac manifestations were present in 25% of patients with KD, 20% of children had coronary involvement in the form of an aneurysm, or ectasia. About 73% of patients with coronary dilatation got resolved in 3 months. Significant valvular heart diseases, aortic root involvement, and myocardial contractile dysfunction were not seen in the studied population with KD.
Family Support is Key to Overcome Alcohol Dependence
Authors: Singh Aditya , Thakkar Konark , Pandit Niraj
Published: June 2021

Alcohol dependence is a complex medical, social, and psychological problem. It affects the family life adversely. However, if family takes the lead role, this problem is easily controlled at home level with medical support. A middle-aged male, the only breadwinner of the family, had alcohol dependence for more than 20 years. With family support, he overcame the dependence. The management of this illness has the greatest role of the family and society in addition to medical. Symptomatic management of alcoholism is only a tiny part of the treatment. Once the patient's symptoms are managed, the arduous journey to prevent relapse banks upon the persons own resolve and the support offered by their family. This is a peculiar case where medical aid and family support are playing an important role in the elimination of alcohol dependence. The family support models will helpful to the primary health-care physician to reduce alcohol dependence.
Utility of Napsin-A in Diagnosis of nOn-Small Cell Lung Carcinomas and its Addition with Thyroid Transcription Factor-1 (TTF-1) in Small Biopsies of Lung
Authors: Ranjan Richa , Prashar Manoj , Taur Nishant , Singh Sankalp , Lohia Nishant , Sivasubramananian R. , Sundaram Viswanath , Subramananiam Anand
Published: June 2021

Background:

Lung cancer is the leading cause of cancer-related deaths in the world. Primary lung carcinomas were being divided simply as small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) in recent past as the chemotherapy offered in NSCLC was not majorly different in the various subtypes. With the advent of targeted therapy, the management of primary lung adenocarcinomas (PLA) and squamous cell carcinomas (SqCCs) became divergent and hence a stringent separation of the two subgroups is imperative. This study was designed to see whether inclusion of immunohistochemistry (IHC) for Napsin-A in the panel of CK7, CK20, p40, and thyroid transcription factor-1 (TTF-1) improves the diagnostic rates of lung adenocarcinomas.

Materials and Methods:

A total of 56 cases of primary lung malignancies were studied and subtyped, based on Hematoxylin and Eosin stained slides along with IHC for CK 7, CK 20, p40, TTF-1, and Napsin-A. NSCLC was divided into five groups-PLA, SqCC, NSCLC–favor adenocarcinoma, NSCLC–favor SqCC, and NSCLC–not otherwise specified (NOS).

Results:

Out of the total, 38 cases were diagnosed to be NSCLC. Of these 38, only 55% cases were diagnosed using histomorphology alone. The rest required immunohistochemical stains for classification. The NSCLC-NOS group comprised 11% in this study. It was observed that by including Napsin-A in the panel, 01/04 (25%) cases in NSCLC-NOS group could be included in NSCLC–favor adenocarcinoma group.

Conclusions:

This study finds that Napsin-A labels additional cases as adenocarcinomas in NSCLC-NOS group. Napsin-A is more sensitive but less specific than TTF-1 in diagnosis of PLA and has a definite use, in conjunction with TTF-1 to classify NSCLC.
Influence of catechol-O-methyltransferase enzyme gene polymorphism on alcohol and tobacco consumption in North Indian treatment seeking population
Authors: Quraishi Rizwana , Sharma Jaydeep , Jain Raka , Ambekar Atul
Published: June 2021

Background:

The co-occurrence of alcohol and tobacco dependence is frequently witnessed in treatment settings. It is a challenge for clinicians to treat such patients due to their powerful biological association.

Aim:

The study is aimed to assess the relationship of Catechol-O-methyltransferase (COMT) Val158Met polymorphism with substance intake among individuals who are dependent on both alcohol and tobacco.

Materials and Methods:

A cross-sectional study involving patients coming to the outpatient department was planned. Brief information on their sociodemographic and substance use profile was recorded. Genotyping of COMT Val158Met was carried out using established polymerase chain reaction-restriction fragment length polymorphism method. The COMT genotyping was classified based on the presence or absence of Met allele using the dominant model. Descriptive statistics, Chi-square test, Mann–Whitney test, and Binary logistic regression analysis were performed to analyze the data.

Results:

The study included 104 alcohol and nicotine co-dependent subjects. More than eighty percent of the participants were educated above secondary level, married, and employed. The allele frequencies of met and Val were found to be 0.23 and 0.77, respectively. Forty percent of the participants reported tobacco-related health problems. The odds of consuming alcohol and nicotine were four times high among Met allele carriers. While the Fagerström test for nicotine dependence and heaviness of smoking index scores were up to four and eight times higher among met allele (odds ratio 4.3 and 8.9, respectively).

Conclusion:

Patients carrying Met allele are reported to consume higher amounts of alcohol and tobacco and were likely to score high among measures of nicotine dependence. Thus met allele carriers needs additional attention for a successful treatment outcome.
A Radó theorem for complex spaces
Authors: Vîjîitu Viorel
Published: June 2021

We generalize Radó’s extension theorem from the complex plane to reduced complex spaces.
Le tolérantisme musical – komentarji k študiji Antoinea Bemetzriederja o nacionalnih glasbenih kulturah v 18. stoletju. Pripombe k spoznavoslovju glasbe
Authors: Stefanija Leon
Published: June 2021

Prispevek prinaša komentirani prevod publikacije Antoinea Bemetzriederja Le tolérantisme musical (1779). Njegov spis skozi diskusijo o treh glavnih glasbenih kulturah Evrope in prevladi ene (italijanske nad nemško in francosko) v enaki meri razkriva sociološke koordinate nacionalne identitete glasbe v 18. stoletju (in ponuja pragmatično »pravo rešitev« vprašanja nacionalne glasbe: postavitev nacionalne francoske opere) kakor tudi ponuja pomembne spoznavoslovne iztočnice raziskovanja glasbe, ki so tudi danes vredne upoštevanja. Komentarji k prevodu se nanašajo na spoznavoslovne iztočnice, puščajoč ob strani za ta spis sicer zgodovinsko pomembne vsebine.
“Unusual, Gentle Sensory Stimuli”: A Psychoanalytical Path to the Early Aesthesis of Hans Werner Henze
Authors: Bielefeldt Christian
Published: June 2021

Musicology and psychoanalysis still face each other strangely. Yet, there are quite fruitful initiatives for dealing with musical phenomena from a psychoanalytical perspective, as this article tries to show with the example of the early music aesthetics of Hans Werner Henze. Led by the Lacanian model of imaginary-symbolic-real, Henzes texts from from the 1950s are read in a way in which the aesthetics “of a free, wild sound” is linked to the requirement of music being communicative. Musical communication is understood thereby differently as in the later, politically engaged phase of Henze. It is still understood as an excessive moment of the conventional auditive signs, in which listener dissolves the traditionally fixed senses. With Lacan, this situation of hearing may be described as a musical representation of the ‘I’, which is fundamentally more unstable than linguistic self-representations, leading consequently toward an enjoyment as a condition of temporary self-loss.
A Capricious Aspect of a Haydn Quartet: Parallels Linking Musical Phrasing to Italian Poetic Theory
Authors: Hansell Sven H.
Published: June 2021

Haydn’s Quartet op. 9, no.6, illustrates the application of poetic conventions to music. Viewed as a Capriccio, movement 1 discloses a labyrinthine rhythmic structure both didactic and amusing. A table of musical rhythms and inventory of musical phrase types supplement analyses.
Perceptions, outcomes and attitudes experienced by scholars on stream bio-monitoring through the implementation of the mini-SASS method, using a social learning lens: KwaZulu-Natal, South Africa
Authors: Singh Samiksha , Dent M , Hill Trevor
Published: June 2021

One way of undertaking experiential learning is through the mini-SASS method used as an event of a larger social learning process. The mini-SASS method is used to indicate the ecological condition, at a point in a stream by identifying the macro-invertebrates found at that location. The macro-invertebrates are assigned a sensitivity score which indicates the taxonomic group’s tolerance to pollution. The averaged sensitivity scores of the macro-invertebrates identified are used to determine the ecological condition of the river. This method is said to be user friendly and can be carried out by civil society and scholars. The aim of the project was to determine the perceptions, outcomes and attitude experienced by 12-year-old learners when conducting mini-SASS. The research was guided by the Mintzberg model of learning, which involves a cyclic process including theoretical knowledge, practical implementation followed by reflection. The mini-SASS method was perceived in a positive light by the learners and teacher whose attitude was enthusiastic and the outcome was considered by the learners, teacher and researcher to be a success.
Vecindades conflictivas y relaciones interétnicas en el Nuevo Reino de Granada durante el periodo de dominio hispánico / Conflictive neighborhoods and inter-ethnic relations in the New Kingdom of Granada during the period of Hispanic rule
Authors: Pita Pico Roger
Published: June 2021

El artículo examina las invasiones de ganados pertenecientes a blancos y mestizos y su afectación en los sembradíos que tenían los indígenas al interior de los resguardos del nororiente del Nuevo Reino de Granada en los siglos XVII y XVIII. Era esta una expresión de las complejas relaciones interétnicas entretejidas en torno a aquellos territorios ocupados por los nativos y una prueba fehaciente de la porosidad de las fronteras entre estos espacios y el mundo externo caracterizado por una alta densidad de población libre. Amparados por la política proteccionista diseñada por la Corona, los indígenas afectados no dudaron en hacer valer sus derechos y en acudir a los recursos legales para exigir las debidas indemnizaciones y, de manera extraordinaria, se les autorizó para que tomaran las represalias del caso a través de la posibilidad de incautar y disponer de los semovientes intrusos. En otros casos, fue posible también observar algunas iniciativas de acuerdos formales entre las partes.
Challenges and Opportunities for Educational Actors in light of the COVID-19 Pandemic in Paraguay / Desafíos y oportunidades para los actores educativos ante la pandemia de COVID-19 en Paraguay
Authors: Canese Valentina , Mereles Juan Ignacio , Amarilla Jessica
Published: June 2021

The measures implemented in response to COVID-19 have affected education systems around the world, generating significant disruptions. This study examines the main challenges and opportunities presented to the different educational actors in Paraguay considering the health emergency and the need to give continuity to the educational processes in the country from the last week of March until the first days of May 2020. A total of 2501 people participated, including teachers, students, parents of non-university students, and managers from educational institutions at all levels and from all over the country. It follows a mixed-quan-qual explanatory approach and data collection was conducted through online questionnaires. The study showed changes and strategies implemented by educational actors for the development of classes mediated by digital tools. The results reflect challenges related to access to technological resources, training in the use of ICT, and difficulties in carrying out school activities. Among the opportunities mentioned is the possibility of continuing with studies, learning about technology, and transforming the educational system. These show evidence of the need to improve access to technology to guarantee equal educational opportunities in the country.