bluuebunny/crossref_metadata_2025 huggingface dataset:
On the duration of face-to-face contacts
Authors: Plaszczynski Stéphane , Nakamura Gilberto , Grammaticos Basile , Badoual Mathilde
Published: January 2024

The analysis of social networks, in particular those describing face-to-face interactions between individuals, is complex due to the intertwining of the topological and temporal aspects. We revisit here both, using public data recorded by the sociopatterns wearable sensors in some very different sociological environments, putting particular emphasis on the contact duration timelines. As well known, the distribution of the contact duration for all the interactions within a group is broad, with tails that resemble each other, but not precisely, in different contexts. By separating each interacting pair, we find that the fluctuations of the contact duration around the mean-interaction time follow however a very similar pattern. This common robust behavior is observed on 7 different datasets. It suggests that, although the set of persons we interact with and the mean-time spent together, depend strongly on the environment, our tendency to allocate more or less time than usual with a given individual is invariant, i.e. governed by some rules that lie outside the social context. Additional data reveal the same fluctuations in a baboon population. This new metric, which we call the relation “contrast”, can be used to build and test agent-based models, or as an input for describing long duration contacts in epidemiological studies.
On the Local Metric Dimension of Graphs
Authors: Yang Chenxu , Deng Xingchao , Liang Jinxia , Liu Yuhu
Published: January 2024

Let [Formula: see text] be a graph. A set [Formula: see text] is a local resolving set of [Formula: see text] if there exists [Formula: see text] such that [Formula: see text] for any [Formula: see text]. The local metric dimension [Formula: see text] of [Formula: see text] is the minimum cardinality of all the local resolving sets of [Formula: see text]. In this paper, we characterize the graphs with [Formula: see text]. Next, we obtain the Nordhaus–Gaddum-type results for local metric dimension. Finally, the local metric dimension of several graph classes is given.
Food as a Feminist Issue
Authors: Chopra Simran , Kirts Leah
Published: January 2024

This forum is dedicated to exploring the notion of meaningfulness in design processes, taking the perspectives of community groups, nongovernmental organizations, and those who are marginalized in society as starting points. Authors will reflect conceptually and methodologically on practical engagements. ---
Rosanna Bellini and Angelika Strohmayer, Editors
Evolutionary Optimization with a Simplified Helper Task for High-Dimensional Expensive Multiobjective Problems
Authors: Wu Xunfeng , Lin Qiuzhen , Zhou Junwei , Liu Songbai , Coello Coello Carlos A. , Leung Victor C. M.
Published: January 2024

In recent years, surrogate-assisted evolutionary algorithms (SAEAs) have been sufficiently studied for tackling computationally expensive multiobjective optimization problems (EMOPs), as they can quickly estimate the qualities of solutions by using surrogate models to substitute for expensive evaluations. However, most existing SAEAs only show promising performance for solving EMOPs with no more than 10 dimensions, and become less efficient for tackling EMOPs with higher dimensionality. Thus, this article proposes a new SAEA with a simplified helper task for tackling high-dimensional EMOPs. In each generation, one simplified task will be generated artificially by using random dimension reduction on the target task (i.e., the target EMOPs). Then, two surrogate models are trained for the helper task and the target task, respectively. Based on the trained surrogate models, evolutionary multitasking optimization is run to solve these two tasks so that the experiences of solving the helper task can be transferred to speed up the convergence of tackling the target task. Moreover, an effective model management strategy is designed to select new promising samples for training the surrogate models. When compared to five competitive SAEAs on four well-known benchmark suites, the experiments validate the advantages of the proposed algorithm on most test cases.
What do Trains, Horses, and Home Internet Installation have in Common?
Authors: Limoncelli Thomas A.
Published: January 2024

At first, I thought he was just trying to shirk his responsibilities and pass the buck on to someone else. His advice, however, made a lot of sense. The installation team probably generated configurations ahead of time, planned out how and when those changes need to be activated, and so on. The entire day is planned ahead. Bureaucracies usually have a happy path that works well, and any deviation requires who knows what? Managers getting involved? Error-prone manual steps? Ad hoc database queries? There's no way I could know. The point was clear, however: Don't change horses midstream, or the color of the train.
Predicting Group Choices from Group Profiles
Authors: Emamgholizadeh Hanif , Delić Amra , Ricci Francesco
Published: January 2024

Group recommender systems (GRSs) identify items to recommend to a group of people by aggregating group members’ individual preferences into a group profile and selecting the items that have the largest score in the group profile. The GRS predicts that these recommendations would be chosen by the group by assuming that the group is applying the same preference aggregation strategy as the one adopted by the GRS. However, predicting the choice of a group is more complex since the GRS is not aware of the exact preference aggregation strategy that is going to be used by the group.

To this end, the aim of this article is to validate the research hypothesis that, by using a machine learning approach and a dataset of observed group choices, it is possible to predict a group’s final choice better than by using a standard preference aggregation strategy. Inspired by the Decision Scheme theory, which first tried to address the group choice prediction problem, we search for a group profile definition that, in conjunction with a machine learning model, can be used to accurately predict a group choice. Moreover, to cope with the data scarcity problem, we propose two data augmentation methods, which add synthetic group profiles to the training data, and we hypothesize that they can further improve the choice prediction accuracy.

We validate our research hypotheses by using a dataset containing 282 participants organized in 79 groups. The experiments indicate that the proposed method outperforms baseline aggregation strategies when used for group choice prediction. The method we propose is robust with the presence of missing preference data and achieves a performance superior to what humans can achieve on the group choice prediction task. Finally, the proposed data augmentation method can also improve the prediction accuracy. Our approach can be exploited in novel GRSs to identify the items that the group is likely to choose and to help groups to make even better and fairer choices.
A Survey on Network Attack Surface Mapping
Authors: Everson Douglas , Cheng Long
Published: January 2024

Network services are processes running on a system with network exposure. A key activity for any network defender, penetration tester, or red team is network attack surface mapping, the act of detecting and categorizing those services through which a threat actor could attempt malicious activity. Many tools have arisen over the years to probe, identify, and classify these services for information and vulnerabilities. In this article, we survey network attack surface mapping by reviewing several prominent tools and their features and then discussing recent works reflecting unique research using those tools. We conclude by covering several promising directions for future research.
Modality-collaborative Transformer with Hybrid Feature Reconstruction for Robust Emotion Recognition
Authors: Chen Chengxin , Zhang Pengyuan
Published: January 2024

As a vital aspect of affective computing, Multimodal Emotion Recognition has been an active research area in the multimedia community. Despite recent progress, this field still confronts two major challenges in real-world applications: (1) improving the efficiency of constructing joint representations from unaligned multimodal features and (2) relieving the performance decline caused by random modality feature missing. In this article, we propose a unified framework, Modality-Collaborative Transformer with Hybrid Feature Reconstruction (MCT-HFR), to address these issues. The crucial component of MCT is a novel attention-based encoder that concurrently extracts and dynamically balances the intra- and inter-modality relations for all associated modalities. With additional modality-wise parameter sharing, a more compact representation can be encoded with less time and space complexity. To improve the robustness of MCT, we further introduce HFR, which consists of two modules: Local Feature Imagination (LFI) and Global Feature Alignment (GFA). During model training, LFI leverages complete features as supervisory signals to recover local missing features, while GFA is designed to reduce the global semantic gap between pairwise-complete and -incomplete representations. Experimental evaluations on two popular benchmark datasets demonstrate that our proposed method consistently outperforms advanced baselines in both complete and incomplete data scenarios.
Pulse Electroplating of Gold-Nickel Alloys: Morphological and Aesthetic Improvement Compared to DC
Authors: Mariani Elena , Giurlani Walter , Verrucchi Margherita , dell’Aquila Vincenzo , Lo Nostro Pierandrea , Innocenti Massimo
Published: January 2024

The use of pulsed current is well known as a research tool to study the electrodeposition mechanism of metals, however, it was realized that this method could provide a means to improve the properties of deposits. Electrodeposition of gold or its alloys is not only used in the electronics industry due to its conductive and anti-corrosive properties, but also as a final layer due to its aesthetic properties. In this study we focused on a cyanide gold-nickel bath, among the most frequently used in the electroplating industry intended for the decorative sector. The use of modulated currents has proven to be an effective methodology to be able to control and improve the chemical and physical characteristics of metal deposits. Deposits obtained through pulsed currents have a smaller grain size and a more homogeneous surface, both at the level of thickness dispersion on the surface and at the roughness of the samples themselves. A direct consequence of the above results is the improvement of the aesthetic finish of the workpieces with an increase in brightness as well as anti-corrosive properties.
Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment
Authors: van der Velden Anouk I. M. , Koudijs Angela , Kooijman Sander , Rietjens Rosalie G. J. , Sol Wendy M. P. J. , Avramut M. Cristina , Wang Gangqi , Rensen Patrick C. N. , Rabelink Ton J. , van der Vlag Johan , van den Berg Bernard M.
Published: January 2024

Repeated fasting mimicking diet (FMD) partially prevents glomerular damage in a diabetic mouse model; however, although endothelial glycocalyx heparan sulfate contents were preserved, hyaluronan surface expression was reduced in the presence of UDP-glucuronic acid. The weight loss observed was of lean mass, not fat mass, and increased glomerular oxidative stress argue whether such a diet is safe in patients with diabetes.
The anterior chamber of the eye technology and its anatomical, optical, and immunological bases
Authors: Yang Shao-Nian , Shi Yue , Berggren Per-Olof
Published: January 2024

The anterior chamber of the eye (ACE) is distinct in its anatomy, optics, and immunology. This guarantees that the eye perceives visual information in the context of physiology even when encountering adverse incidents like inflammation. In addition, this endows the ACE with the special nursery bed iris enriched in vasculatures and nerves. The ACE constitutes a confined space enclosing an oxygen/nutrient-rich, immune-privileged, and less stressful milieu as well as an optically transparent medium. Therefore, aside from visual perception, the ACE unexpectedly serves as an excellent transplantation site for different body parts and a unique platform for noninvasive, longitudinal, and intravital microimaging of different grafts. On the basis of these merits, the ACE technology has evolved from the prototypical through the conventional to the advanced version. Studies using this technology as a versatile biomedical research platform have led to a diverse range of basic knowledge and in-depth understanding of a variety of cells, tissues, and organs as well as artificial biomaterials, pharmaceuticals, and abiotic substances. Remarkably, the technology turns in vivo dynamic imaging of the morphological characteristics, organotypic features, developmental fates, and specific functions of intracameral grafts into reality under physiological and pathological conditions. Here we review the anatomical, optical, and immunological bases as well as technical details of the ACE technology. Moreover, we discuss major achievements obtained and potential prospective avenues for this technology.
Synthesis and Networking of Spaceborne Deployable Prismatic Antenna Mechanisms Based on Graph Theory
Authors: Zhu Jialong , Shi Chuang , Fan Xiaodong , Ma Xiaofei , Guo Hongwei , Zheng Shikun , Liu Rongqiang
Published: January 2024

Spaceborne deployable cylindrical antennas have broad application prospects in the fields of space earth observation and remote-sensing detection because of their significant advantages of ultralong aperture, high gain, and flexible beam scanning. As application requirements rapidly develop, a new type of spaceborne deployable cylindrical antenna mechanism with a large diameter and deployability is urgently needed. This paper presents an innovative design for a cylindrical deployable antenna mechanism based on 18R triangular prism elements based on graph theory. The correctness of the configuration is verified by developing a prototype. First, four kinds of nonoverconstrained 12-bar triangular prism-stabilized truss structure configurations and their corresponding topological diagrams are constructed. Second, based on graph theory, three types of 102 triangular prism-stabilized truss mechanism configurations that can be folded into linear mechanisms are derived. Third, the kinematic pair configuration is established to achieve a single-degree-of-freedom 7R2U9S triangular prism deployable unit. Fourth, combined with the geometric topology characteristics of the unit network, a triangular prism unit networking method is proposed, and a cylindrical network mechanism configuration based on 18R triangular prism units is obtained. A prototype was fabricated by 3D printing, and an expansion and retraction function test was conducted, which verified the correctness of the theoretical analysis in this paper. Finally, a new concept configuration for a parabolic cylindrical antenna is proposed. This paper provides a reference for the configuration of large-scale folding truss structures with unit expansion.
Prevalence of Maxillary and Mandibular Frenal Attachment and Its Association with Age, Gender, and Oral Hygiene Status in Nepalese Population Seeking Dental Treatment
Authors: Rijal Arjun Hari , Humagain Manoj , Lamichhane Simant , Ghimire Pratistha , Thapa Sachita
Published: January 2024

Objective. Frenum attachments are folds of mucous membrane that connect the lips to the alveolar mucosa and underlying periosteum. Aberrant positioning of the maxillary and mandibular labial frenum can lead to various clinical issues, including mucogingival problems and midline diastema. The objective of this study was to assess the prevalence of maxillary and mandibular frenal attachments and their association with age, gender, and oral hygiene status in the Nepalese population seeking dental treatment. Materials and Methods. This descriptive cross‐sectional study was conducted over a period of 6 months, from February 2023 to August 2023, among patients visiting the Department of Periodontology and Oral Implantology, aged 6 years and above, after obtaining official permission from the Institutional Review Committee (IRC‐KUSMS Approval No. 8/23). The study collected data on morphological variations of frenal attachment and various periodontal parameters such as Oral Hygiene Index‐Simplified (OHI‐S), pocket depth, recession, and midline diastema in both arches. Descriptive statistics, including frequency and percentage, were used to analyze the data. The χ2‐test was employed to determine the correlation between gender and types of frenulum attachment, while analysis of variance was used to assess the association of frenal attachments with oral hygiene status. Results. Among 380 patients, the prevalence of frenal attachment was as follows: gingival 248 (65.30%), mucosal 71 (18.70%), papillary 42 (11.10%), and papillary penetrating 19 (5.00%) in the maxilla, and mucosal 225 (59.20%) and gingival 155 (40.78%) in mandible. Among the different morphological variations of frenal attachments, normal frenum was the most common, accounting for 231 cases (60.80%), followed by frenum with a nodule, with 101 cases (26.60%). Conclusions. The study found significant associations between frenal attachment and gender, as well as oral hygiene status. The prevalence of frenal attachments in this study was comparable to findings from previous research.
A Dynamic Interrelationships among Clean Energy, Environmental Pollution, and Economic Growth in GCC Economies: A Panel ARDL Approach
Authors: Hazmi Abdulaziz , Kort Hanene Matoussi , Khallouli Wajih , Raissi Nizar
Published: January 2024

The paper investigates the interplay between clean energy, environmental pollution reduction, and economic growth in the Gulf Cooperation Council (GCC) countries from 1980 to 2019, utilizing the autoregressive distributed lag (ARDL) method. The study underscores the global transition towards cleaner energy sources and its implications for the region. In assessing the determinants of economic growth, the findings reveal a positive and significant short‐ and long‐term impact of energy production, with energy consumption exhibiting a positive and significant effect solely in the long term. The absence of a confirmed relationship in the short term is notable. Causality tests demonstrate a significant link from both energy consumption types to environmental pollution, alongside causal relationships from urbanization, energy production, and consumption to economic growth. Moreover, the results include the pivotal role of energy production in driving GDP growth, caution in short‐term energy consumption effects, and significant causal links between energy consumption and environmental pollution. The recommendations to incentivize sustainable energy production, engage in long‐term energy consumption planning, and adopt integrated urbanization policies provide actionable insights for policymakers. These suggestions are aimed at guiding the GCC countries in balancing the pursuit of economic growth with environmental sustainability—a delicate equilibrium that necessitates careful consideration of various factors.
Malignant Epithelioid Mesothelioma of the Tunica Vaginalis Testis Presenting as Hydrocele in a Kidney Transplant Recipient
Authors: Behers Brett M. , Guske Christopher W. , Behers Benjamin J. , Kortum Spencer B. , Bermingham Isabella G. , Warner Christina L. , Carey Robert I.
Published: January 2024

Mesotheliomas of the tunica vaginalis testis are rare malignant tumors that can present as a scrotal mass or hydrocele. These tumors are typically aggressive with high rates of recurrence and metastasis. Suspected risk factors for malignant mesothelioma include asbestos exposure, chronic inflammation, trauma, and persistent hydrocele. We report the case of a malignant epithelioid mesothelioma of the tunica vaginalis testis that presented as a finding at hydrocelectomy and was ultimately treated with radical inguinal orchiectomy. This patient was on chronic immunosuppression therapy with tacrolimus and mycophenolate mofetil secondary to a kidney transplant but had none of the common risk factors for mesothelioma formation. To our knowledge, this is the first case describing a possible connection between chronic immunosuppression and mesothelioma of the tunica vaginalis. However, future studies are needed to investigate this association and discern whether this could have played a role in our patient or if his mesothelioma formation was coincidental.
Data from 3-Phosphoinositide–Dependent Protein Kinase-1 Regulates Proliferation and Survival of Cancer Cells with an Activated Mitogen-Activated Protein Kinase Pathway
Authors: Lu Zhuomei , Cox-Hipkin Mary Ann , Windsor William T. , Boyapati Anita
Published: January 2024

Abstract
Engagement of cell surface receptor tyrosine kinases by insulin and growth factors activates phosphatidylinositol 3-kinase (PI3K) and generates the second messenger, phosphatidylinositol 3,4,5-trisphosphate. This second messenger leads to the recruitment of 3-phosphoinositide–dependent protein kinase-1 (PDK1) to the proximal side of the plasma membrane, which results in the activation of AKT kinase. In addition, PDK1 can phosphorylate numerous other kinases, including p90RSK, a kinase downstream of mitogen-activated protein kinase (MAPK) that is important for cell proliferation and survival. Previous studies have shown that the loss of PDK1 sensitizes tumor cells to chemotherapeutic agents and radiation but have not focused on delineating the contribution of PDK1 to pathway-specific mutations associated with various cancers other than the PI3K/AKT pathway. In this study, we show that the reduction of PDK1 by RNAi in melanoma and colon cancer cell lines activated in the MAPK pathway results in significant cell growth inhibition and apoptosis. Furthermore, PDK1 reduction in tumor cells resulted in impaired PAK kinase signaling, altered actin polymerization, and reduced cell migration. These studies show that PDK1 plays a pivotal role in MAPK and PI3K signaling in tumor cells. Mol Cancer Res; 8(3); 421–32
Data from Skp2 Directs Myc-Mediated Suppression of p27Kip1 yet Has Modest Effects on Myc-Driven Lymphomagenesis
Authors: Old Jennifer B. , Kratzat Susanne , Hoellein Alexander , Graf Steffi , Nilsson Jonas A. , Nilsson Lisa , Nakayama Keiichi I. , Peschel Christian , Cleveland John L. , Keller Ulrich B.
Published: January 2024

Abstract
The universal cyclin-dependent kinase inhibitor p27Kip1 functions as a tumor suppressor, and reduced levels of p27Kip1 connote poor prognosis in several human malignancies. p27Kip1 levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the E3 ubiquitin ligase SCFSkp2 complex following its phosphorylation by the cyclin E–cyclin-dependent kinase 2 complex. Binding of phospho-p27Kip1 is directed by the Skp2 F-box protein, and this is greatly augmented by its allosteric regulator Cks1. We have established that programmed expression of c-Myc in the B cells of Eμ-Myc transgenic mice triggers p27Kip1 destruction by inducing Cks1, that this response controls Myc-driven proliferation, and that loss of Cks1 markedly delays Myc-induced lymphomagenesis and cancels the dissemination of these tumors. Here, we report that elevated levels of Skp2 are a characteristic of Eμ-Myc lymphomas and of human Burkitt lymphoma that bear MYC/Immunoglobulin chromosomal translocations. As expected, Myc-mediated suppression of p27Kip1 was abolished in Skp2-null Eμ-Myc B cells. However, the effect of Skp2 loss on Myc-driven proliferation and lymphomagenesis was surprisingly modest compared with the effects of Cks1 loss. Collectively, these findings suggest that Cks1 targets, in addition to p27Kip1, are critical for Myc-driven proliferation and tumorigenesis. Mol Cancer Res; 8(3); 353–62
Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells
Authors: Zoubeidi Amina , Ettinger Susan , Beraldi Eliana , Hadaschik Boris , Zardan Anousheh , Klomp Leo W.J. , Nelson Colleen C. , Rennie Paul S. , Gleave Martin E.
Published: January 2024

Abstract
Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast cancer. However, the molecular mechanisms by which sCLU inhibits treatment-induced apoptosis in prostate cancer remain incompletely defined. We report that sCLU increases NF-κB nuclear translocation and transcriptional activity by serving as a ubiquitin-binding protein that enhances COMMD1 and I-κB proteasomal degradation by interacting with members of the SCF-βTrCP E3 ligase family. Knockdown of sCLU in prostate cancer cells stabilizes COMMD1 and I-κB, thereby sequestrating NF-κB in the cytoplasm and decreasing NF-κB transcriptional activity. Comparative microarray profiling of sCLU-overexpressing and sCLU-knockdown prostate cancer cells confirmed that the expression of many NF-κB–regulated genes positively correlates with sCLU levels. We propose that elevated levels of sCLU promote prostate cancer cell survival by facilitating degradation of COMMD1 and I-κB, thereby activating the canonical NF-κB pathway. Mol Cancer Res; 8(1); 119–30
Data from Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of β-Catenin
Authors: Li Huchun , Sekine Masayuki , Tung Nadine , Avraham Hava Karsenty
Published: January 2024

Abstract
BRCA1 is an essential caretaker protein in the surveillance of DNA damage, is mutated in ∼50% of all hereditary breast cancer cases, and its expression is frequently decreased in sporadic breast cancer. β-Catenin is a multifunctional protein that forms adhesion complex with E-cadherins, α-catenin, and actin, and plays a central role in Wnt signaling through its nuclear translocation and activation of β-catenin–responsive genes. Although significant progress has been made in understanding the Wnt/β-catenin and BRCA1 signaling cascades, it is not known whether there is a link between β-catenin and BRCA1. We observed that the expression of the active nuclear form of β-catenin (also known as ABC, Ser37/Thr41-nonphosphorylated β-catenin, dephosphorylated β-catenin) was lower or absent in the nucleus in most BRCA1 familial breast cancer tissues (17 cases) compared with sporadic breast cancer (14 samples) and normal breast tissues. Wild-type-BRCA1, but not mutated BRCA1, interacted with β-catenin and increased the levels of β-catenin protein expression in vitro. Furthermore, H2O2 induced the interaction of the nuclear form of β-catenin with BRCA1. The active form of β-catenin protein was downregulated upon exposure to H2O2 in the nucleus of BRCA1-deficient HCC1937 breast cancer cells, whereas reconstitution of WT-BRCA1 in HCC1937 cells inhibited this downregulation. This study provides evidence of a novel interaction between BRCA1 and β-catenin, and that loss of BRCA1 leads to impaired expression of the nuclear form of β-catenin, which may contribute to the pathogenesis of breast cancer. Mol Cancer Res; 8(3); 407–20
Figure S1 from Analysis of Changes in Plasma Cytokine Levels in Response to IL12 Therapy in Three Clinical Trials
Authors: Schwarz Emily , Benner Brooke , Yu Lianbo , Tounkara Fode , Carson William E.
Published: January 2024

Difference in cytokine fluxes between progressive disease, stable disease and complete/partially responding patients.
International Cohort of Neonatal Timothy Syndrome
Authors: Matthews Alexandra , Timothy Katherine , Golden Andy , Gonzalez Corcia M. Cecilia
Published: January 2024

Introduction: Timothy syndrome (TS) is an extremely rare, multisystem disorder classically associated with long QT, syndactyly, ventricular arrhythmias, and hypoglycaemia. A neonatal diagnosis allows maximal medical and device therapy to be implemented to avoid malignant arrhythmias and sudden cardiac death. Methods: This was a retrospective case series study of type I TS (TS1) patients using data from the Timothy Syndrome Foundation’s international registry, encompassing patients with a genetic diagnosis (CACNA1C variant G406R in exon 8A) recruited over a 28-year period. Results: Forty-four cases of TS1 were included (26 male; 60%). Mean gestational age (GA) was 35.6 weeks (range 28 weeks – term), with 43% of patients born less than 37 weeks GA. In TS1 patients presenting with foetal bradycardia, mean GA was significantly lower (34.2 weeks, p < 0.05). Foetal bradycardia secondary to atrioventricular block was present in 20 patients (45%), resulting in premature delivery in 14 patients (32%). Fifteen patients (34%) were diagnosed with TS1 as neonates. Long QT at birth helped secure a diagnosis in 25 patients (57%). Syndactyly was seen in most patients (n = 40, 91%). Twenty patients died, with an average age of death of 2.3 years (range 1 month–6 years). Of the 7 patients who died before the first year of life (16%), the average age of death was 2.5 months. Conclusion: TS is associated with high early mortality. TS should be considered in paediatric patients presenting with long QT and syndactyly. Recognition of TS in the neonatal period allows for early intervention to prevent life-threatening arrhythmias.
Treatment of Hemodialysis Vascular Access Repeated Stenosis with Paclitaxel-Coated Balloon Angioplasty: A Retrospective Study
Authors: Chen Chao , Gao Jun , Gong Feng , Liu Lihua , Shi Peng , Ma Shengyin
Published: January 2024

Introduction: The objective of this study was to report our experience of angioplasty with paclitaxel-coated balloon (PCB) versus common balloon (CB) for the treatment of repeated failing vascular access. Methods: Retrospective, single-center analysis consisting of 88 patients treated with percutaneous transluminal angioplasty in the period from October 2020 through December 2021. Patients were divided into two groups according to the type of treatment as PCB (n = 41) and CB (n = 47). We analyzed target lesion primary patency and vascular access primary patency for 6 months and the rate of complications. Results: There was no significant difference in the target lesion primary patency which was similar for 6 months between the two groups (PCB group vs. CB group at 1, 3, and 6 months; 95.12 vs. 89.36% (p = 0.55), 75.61 versus 74.47% (p = 0.90), 53.66% versus 63.83% (p = 0.33), respectively). Similarly, vascular access primary patency in the PCB group and CB group was 90.24 and 89.36% (p = 0.83), respectively, at 1 month, 65.85 and 68.09% (p = 0.82), respectively, at 3 months, 39.02 and 53.19% (p = 0.18), respectively, at 6 months. There were no major complications after endovascular treatment. Conclusion: Compared to CB angioplasty, PCB angioplasty has no short-term patency benefit in the treatment of vascular access repeated stenosis.
Is reassessment of Computed Tomography Reports Worthwhile in Acute Diverticulitis?
Authors: Mäntymäki Leena-Mari , Grönroos Juha , Aronen Anu , Karvonen Jukka , Ukkonen Mika
Published: January 2024

Introduction: Since the assessment of the disease severity in acute diverticulitis (AD) is of utmost importance to determine the optimal treatment and the need for follow-up investigations, we wanted to investigate whether the first CT report is compatible with daytime reassessment report and whether the value of initial report changes according to the experience of the radiologist. Methods: Consecutive patients from tertiary referral centre with AD were included. CT images done in the emergency department were initially analysed by either resident radiologists or consultant radiologists and then later reanalysed by consultant abdominal radiologists. Discrepancies between reports were noted. Results: Of total of 562 patients with AD, CT images were reanalysed in 439 cases. In 22 reports (5.0%) the final report was significantly different from the initial report and management changed in 20 cases. In reports of uncomplicated acute diverticulitis, reanalysis changed initial assessment in 4.0% of the cases and in complicated acute diverticulitis (CAD) in 9.1%. When consultant and resident radiologists were compared, there was no significant difference. Conclusion: Although no statistical difference could be noted between residents and consultants, the final report was significantly different in overall 5% of the cases when reanalysed at normal working hours by an experienced consultant abdominal radiologist. Therefore, we conclude that reassessment of CT reports is worthwhile in AD.
Management of Patients Undergoing CAR-T Cell Therapy in Germany
Authors: Penack Olaf , Dreger Peter , Ajib Salem , Ayuk Francis , Baermann Ben-Niklas , Bug Gesine , Kriege Oliver , Jentzsch Madlen , Kobbe Guido , Koenecke Christian , Lutz Mathias , Martin Sonja , Schlegel Paul-Gerhard , Schroers Roland , von Tresckow Bastian , Vucinic Vladan , Subklewe Marion , Bethge Wolfgang , Wolff Daniel
Published: January 2024

Introduction: Chimeric antigen receptor positive T cell (CAR-T cell) treatment became standard therapy for relapsed or refractory hematologic malignancies, such as non-Hodgkin’s lymphoma and multiple myeloma. Owing to the rapidly progressing field of CAR-T cell therapy and the lack of generally accepted treatment guidelines, we hypothesized significant differences between centers in the prevention, diagnosis, and management of short- and long-term complications. Methods: To capture the current CAR-T cell management among German centers to determine the medical need and specific areas for future clinical research, the DAG-HSZT (Deutsche Arbeitsgemeinschaft für Hämatopoetische Stammzelltransplantation und Zelluläre Therapie; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy) performed a survey among 26 German CAR-T cell centers. Results: We received answers from 17 centers (65%). The survey documents the relevance of evidence in the CAR-T cell field with a homogeneity of practice in areas with existing clinical evidence. In contrast, in areas with no – or low quality – clinical evidence, we identified significant variety in management in between the centers: management of cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, IgG substitution, autologous stem cell backups, anti-infective prophylaxis, and vaccinations. Conclusion: The results indicate the urgent need for better harmonization of supportive care in CAR-T cell therapies including clinical research to improve clinical outcome.
The Delivery Room Resuscitation of Infants with Congenital Diaphragmatic Hernia Treated with Fetoscopic Endoluminal Tracheal Occlusion: Beyond the Balloon
Authors: Wild K. Taylor , Rintoul Natalie E. , Ades Anne M. , Gebb Juliana S. , Moldenhauer Julie S. , Mathew Leny , Flohr Sabrina , Bostwick Anna , Reynolds Tom , Ruiz Ryan L. , Javia Luv R. , Nelson Olivia , Peranteau William H. , Partridge Emily A. , Adzick N. Scott , Hedrick Holly L.
Published: January 2024

Introduction: Randomized controlled trials found that fetoscopic endoluminal tracheal occlusion (FETO) resulted in increased fetal lung volume and improved survival for infants with isolated, severe left-sided congenital diaphragmatic hernia (CDH). The delivery room resuscitation of these infants is particularly unique, and the specific delivery room events are largely unknown. The objective of this study was to compare the delivery room resuscitation of infants treated with FETO to standard of care (SOC) and describe lessons learned. Methods: Retrospective single-center cohort study of infants treated with FETO compared to infants who met FETO criteria during the same period but who received SOC. Results: FETO infants were more likely to be born prematurely with 8/12 infants born <35 weeks gestational age compared to 3/35 SOC infants. There were 5 infants who required emergent balloon removal (2 ex utero intrapartum treatment and 3 tracheoscopic removal on placental bypass with delayed cord clamping) and 7 with prenatal balloon removal. Surfactant was administered in 6/12 FETO (50%) infants compared to 2/35 (6%) in the SOC group. Extracorporeal membrane oxygenation use was lower at 25% and survival was higher at 92% compared to 60% and 71% in the SOC infants, respectively. Conclusion: The delivery room resuscitation of infants treated with FETO requires thoughtful preparation with an experienced multidisciplinary team. Given increased survival, FETO should be offered to infants with severe isolated left-sided CDH, but only in high-volume centers with the experience and capability of removing the balloon, emergently if needed. The neonatal clinical team must be skilled in managing the unique postnatal physiology inherent to FETO where effective interdisciplinary teamwork is essential. Empiric and immediate surfactant administration should be considered in all FETO infants to lavage thick airway secretions, particularly those delivered <48 h after balloon removal.
Intertextualidade mitológica presente no episódio de Inês de Castro, transcrito na epopeia camoniana
Authors: Botelho Michael Jones
Published: January 2024

Este artigo tem por objetivo empreender uma análise interpretativa do episódio de Inês de Castro, transcrito em Os Lusíadas (1572), de Luís de Camões, e, sob a perspectiva intertextual, cotejá-lo com as três referências mitológicas presentes no canto – Rainha Semíramis, juntamente com os irmãos Rômulo e Remo, Tiestes e Atreu e, por fim, Polixena e Aquiles. Tais referências aproximam esse episódio às tragédias clássicas, tanto em sua estrutura, quanto em sua temática e corroboram para a importância literária e histórica da tragédia de Inês de Castro, imortalizada por Camões.
Tempo e Memória: constituição do sujeito em A Cidade de Ulisses
Authors: Santos Rosilene Aparecida Froes , Sousa Marcio Jean Fialho de
Published: January 2024

Partindo da perspectiva de que no mundo da pós-modernidade o sentido de todas as coisas está no princípio do movimento e da construção, a proposta deste estudo é analisar como os mecanismos da memória corroboram para a constituição do sujeito por meio de narrativas demonstradas no livro A cidade de Ulisses, de Teolinda Gersão, publicado em 2011. Desse modo, o estudo que segue neste artigo parte dos pressupostos teóricos de que a memória individual e coletiva são auxiliares no processo de construção do sujeito, por meio de processos de rememoração e da percepção da presença do mito, do imaginário e da ficção para o desenvolvimento, não só do eu ou de territórios, mas da própria realidade humana. Para essa análise, foram utilizados, como aporte teórico, as contribuições de Le Goff (1990) e Stuart Hall (2021).
Eurico, o presbítero nos cursos de literatura de Cônego Fernandes Pinheiro e Sotero dos Reis: ensino de literatura, identidade e memória cultural
Authors: Portela Luís Fernando
Published: January 2024

Este artigo propõe uma leitura da exposição da obra Eurico, o presbítero, de Alexandre Herculano nas produções didáticas de história da literatura do Cônego Joaquim Caetano Fernandes Pinheiro (Curso Elementar de Literatura Nacional) e de Francisco Sotero dos Reis (Curso de Literatura Portuguesa e Brasileira). Pretende-se fazer uma análise crítica dessa produção historiográfica como espaço de constituição de memória cultural e afirmação da nacionalidade literária em constante tensão com a herança cultural portuguesa no cenário das letras brasileiras da segunda metade do século XIX. Para tanto, o foco no discurso a respeito do romance de Alexandre Herculano por esses autores pode se tornar capaz de revelar certos aspectos implícitos ou incongruentes do projeto de construção de uma identidade cultural nacional inspirada pelo romantismo: tanto na forma de se representar essa obra contemporânea aos críticos, quanto em seu caráter histórico e épico como ponto de apoio para a distorção dessa representação e apropriação de seu conteúdo mítico. Uma vez que essas são produções de professores, voltadas especificamente para o ensino de literatura, busca-se traçar um panorama de sua inserção nesse âmbito, da consonância das propostas pedagógicas com a orientação crítica e historiográfica dos cursos, além de uma visada às suas estratégias de ensino. Esta análise será sustentada por pesquisas historiográficas a respeito da leitura, do livro didático e do ensino de literatura no Brasil do século XIX, em trabalhos como o de Regina Zilberman e Marisa Lajolo sobre a formação da leitura no país (1996), bem como por contribuições teóricas acerca da formação do cânone literário e da memória cultural, com atenção às produções de Antonio Candido (2000) e Aleida Assmann (2011), respectivamente.
Utopia e Quinto Império em Antônio Vieira
Authors: Bittencourt Roberto Nunes
Published: January 2024

Antônio Vieira é conhecido por ser um escritor entre dois mundos, em uma zona limítrofe tanto cultural quanto literária. Sua produção, bem como as influências que geralmente são apontadas em seus textos, se inscrevem no Barroco. Uma das perguntas que surge daí é justamente como se faz uma leitura de seus trabalhos. Acontece muito de suas obras serem imediatamente rejeitadas, uma vez que se costuma acreditar que elas são de uma linha estética que pouco pode atrair a atenção de um leitor do nosso tempo. Em seu livro História do Futuro, encontramos um Vieira bem distinto do que se pode supor a partir dessas notas biográficas e análises parciais de suas obras. Esse texto tanto nos evidencia que seu autor era capaz de romper com certos traços estilísticos do Barroco, fugindo do tão aversivo cultismo, quanto inovar em alguns dos aspectos mais fundamentais de seu material, fazendo inclusive uma aproximação com obras excepcionais de seu tempo, que marcaram tanto a literatura dos séculos XV e XVI quanto posteriores. Sendo assim, o objetivo deste trabalho é, ao se deter em um exame sobre a História do Futuro identificar, dentre outros aspectos, algumas marcas mais curiosas sobre Veira em sua produção artística, relvando que o Quinto Império português era uma idealização que estava ancorada no pensamento daquele período.
“Enfrentamos todos o desafio das nossas criações, quer lhe chamemos I.A. ou Adamastor”: entrevista a Alberto Manguel
Authors: Baptista Mónica Santana
Published: January 2024

Alberto Manguel tem alma de viajante. Viveu um pouco por todo o mundo, e está actualmente em Lisboa, onde pensa permanecer, uma vez que é na capital portuguesa que está a ser instalada a sua biblioteca como Centro de Estudos da História da Literatura. É um homem para quem o mito está invariavelmente ligado aos livros e a toda a literatura. Mas, também, como bibliógrafo que é, à ideia de biblioteca, como lugar imaginário, e não apenas físico, lugar dinâmico e não apenas ordenado - onde cabem todas as nossas memórias e o que delas, a cada momento, fazemos, sempre e de cada vez que pegamos numa obra, e atravessamos as suas narrativas, espaços e demandas das suas personagens. Foi a propósito do conceito de mito e dos mitos de Portugal, da arte e literaturas portuguesas que Alberto Manguel, argentino de nascença, leitor, em jovem, de Jorge Luis Borges na biblioteca de Buenos Aires, que surgiram muitas questões transversais ao mito e ao país.
Violência, afetos e luta por reconhecimento na criminalidade pauperizada
Authors: Pires Artur
Published: January 2024

O artigo analisa em uma perspectiva compreensiva como as afetividades dos agentes criminais pauperizados – apreendendo dentro desta abordagem aspectos psicoemocionais – se relacionam com suas maneiras de operar as atividades ilegais e com sua luta por reconhecimento. O objetivo central deste trabalho é debater como a opressão estrutural da semiologia dominante provoca, de diferentes formas, afetividades desequilibradas nas pessoas envolvidas com as relações criminais. A pesquisa que deu origem a este trabalho vem sendo desenvolvida desde 2013 nas periferias de Fortaleza, de forma sistemática desde 2016, principalmente em um conjunto de favelas de aproximadamente 30 mil habitantes na região sudeste da capital cearense. Para coleta dos dados empíricos, os métodos utilizados foram conversas espontâneas no campo, entrevistas semiestruturadas, observação direta e diário de campo. Para obtenção dos dados teóricos, os métodos foram leitura, fichamento e sistematização de conceitos. Conclui-se que, diante das opressões estruturais, os agentes criminais pauperizados enfrentam um processo contínuo e recorrente de desgaste emocional, devido principalmente aos riscos de suas atividades. E é a partir de suas práticas violentas que empreendem uma luta por reconhecimento para compensar uma subjetividade marginalizada e oprimida.
Quem são as mulheres encarceradas no Paraná? Mais do que estatísticas, subjetividades e sentimentos nas cartas endereçadas aos excelentíssimos juízes
Authors: Paiva Pamela de Gracia
Published: January 2024

Women have always committed and continue to commit crimes, going against laws and social norms established and considered appropriate for female behavior. Some will be investigated, tried and sentenced to imprisonment. Currently, Brazil is the 3rd country with the largest prison population in the world, reaching a total of 909,000 people behind bars, second only to the United States and China. It is also the 3rd country that most incarcerates women, reaching the mark of 42,600 women incarcerated, a very expressive number, considering that they represent 7% of the prison population in the world. Most are black and poor women, a profile easily criminalized by the justice system. Despite the crimes committed, these women do not lose their humanity, in this way, some fragments of letters written by them to judges and also to family members will be exposed, aiming at their humanization beyond the crime committed. The methodology used will be Discourse Analysis, of the letters that were filed in their medical records, which demonstrate the discourse of reason, truth, operators of law and the law and also that of madness, of the criminal woman, accused and convicted. The richness of these documents comes from being material produced by them, demonstrating their feelings, fears and afflictions regarding prison.
A criação do monstro: sobre milicianos, sujeição criminal e corpo
Authors: Fonseca Tiago Abud da
Published: January 2024

O trabalho tem por objeto avaliar, a partir da representação dos profissionais da Defensoria Pública do Rio de Janeiro, se a expansão das milícias- enquanto fenômeno criminal no território fluminense- guarda relação com a participação de agentes do Estado nesses grupos criminosos e se, em alguma medida, a atuação dos atores do sistema de justiça, a partir do sentido de corpo, colabora com o aumento do poder dessas organizações. Para atingir a finalidade da pesquisa foram realizadas trinta entrevistas semiestruturadas e a análise qualitativa das respostas possibilitou desvendar que, uma dicotomia entre os grupos milicianos e as facções criminosas do varejo das drogas deu aos primeiros o discurso inicial pacificador em confronto com os bandidos, inimigos sociais a serem combatidos. Dentro dessa lógica de guerra às drogas, a sujeição criminal não atingiu os milicianos nos primeiros vinte anos do século XXI, de modo que puderam, abrigados por uma atuação protetora do Estado a algumas práticas autoritárias dos agentes da repressão, expandir os seus negócios, em verdadeira confusão dos papéis de outsiders e insiders.