bluuebunny/crossref_metadata_2025 huggingface dataset:
Spontaneous deep vein thrombosis of the upper arm due to an intravascular myopericytoma: A case report and literature review
Authors: Jang Lee Chan , Yoo Kwon Cheol
Published: February 2024

Introduction:

Intravascular myopericytomas are a rare type of myopericytomas. In most previously reported cases, these were benign, occurred on the legs or neck, and had low recurrence rates. We have described a unique case of an intravascular myopericytoma that caused spontaneous deep vein thrombosis.

Main symptoms, important clinical findings, and main diagnoses:

A 37-year-old man presented with sudden-onset pain and swelling in the upper arm; physical examination revealed a 10 cm, palpable, firm, and mobile lesion in the upper arm. A biopsy revealed intravascular myopericytoma; immunohistological examination revealed a lesion in the lumen of the basilic vein. The tumor comprised abundant myxoid stroma with spindle cells proliferating in a concentric perivascular manner around the blood vessel. The tumor cells stained positive for CD34 and smooth muscle actin.

Therapeutic interventions and outcomes:

The patient underwent total excision of the mass under local anesthesia; no recurrence was observed thereafter. A literature review was performed using PubMed and Google Scholar; the key terms were “intravascular myopericytoma” and “IVMP.” Nineteen cases of intravascular myopericytomas across 14 articles published between January 2002 and January 2022 were identified. These involved 11 men and 7 women (sex was unknown in 1 case); the ages were 22 to 80 years (mean: 59.8 ± 14 years). In most cases, the tumor was slow-growing, and the etiology was previous surgical history or trauma. No pain was reported by patients with tumors on the face or feet, and no recurrence was observed after surgery in any of the reported cases. Immunohistochemical staining for smooth muscle actin, h-caldesmon, calponin, and CD34 was performed for differential diagnosis. Contrary to the slow-growing nature reported in the literature, the nature related to growing in the present case was unclear that lesion was discovered because of sudden pain caused by thrombosis. However, the diagnostic method and recurrence rate in our case were similar to those in the previously reported cases.

Conclusion:

Our case shows that although intravascular myopericytomas are rare, they can cause spontaneous thrombosis. They have low recurrence rates after complete resection. Spontaneous deep vein thrombosis that occurs in rare locations must be treated after determining the causes.
Are fish immunocompetent enough to face climate change?
Authors: Franke Andrea , Beemelmanns Anne , Miest Joanna J.
Published: February 2024

Ongoing climate change has already been associated with increased disease outbreaks in wild and farmed fish. Here, we evaluate the current knowledge of climate change-related ecoimmunology in teleosts with a focus on temperature, hypoxia, salinity and acidification before exploring interactive effects of multiple stressors. Our literature review reveals that acute and chronic changes in temperature and dissolved oxygen can compromise fish immunity which can lead to increased disease susceptibility. Moreover, temperature and hypoxia have already been shown to enhance the infectivity of certain pathogens/parasites and to accelerate disease progression. Too few studies exist that have focussed on acidification, but direct immune effects seem to be limited while salinity studies have led to contrasting results. Likewise, multi-stressor experiments essential for unravelling the interactions of simultaneously changing environmental factors are still scarce. This ultimately impedes our ability to estimate to what extent climate change will hamper fish immunity. Our review about epigenetic regulation mechanisms highlights the acclimation potential of the fish immune response to changing environments. However, due to the limited number of epigenetic studies, overarching conclusions cannot be drawn. Finally, we provide an outlook on how to better estimate the effects of realistic climate change scenarios in future immune studies in fish.
Quantifying the relationship between within-host dynamics and transmission for viral diseases of livestock
Authors: Gubbins Simon
Published: February 2024

Understanding the population dynamics of an infectious disease requires linking within-host dynamics and between-host transmission in a quantitative manner, but this is seldom done in practice. Here a simple phenomenological model for viral dynamics within a host is linked to between-host transmission by assuming that the probability of transmission is related to log viral titre. Data from transmission experiments for two viral diseases of livestock, foot-and-mouth disease virus in cattle and swine influenza virus in pigs, are used to parametrize the model and, importantly, test the underlying assumptions. The model allows the relationship between within-host parameters and transmission to be determined explicitly through their influence on the reproduction number and generation time. Furthermore, these critical within-host parameters (time and level of peak titre, viral growth and clearance rates) can be computed from more complex within-host models, raising the possibility of assessing the impact of within-host processes on between-host transmission in a more detailed quantitative manner.
Nineteenth-century Japanese and British science in context: an introduction to transnational-comparative studies
Authors: Lightman Bernard , Sera-Shriar Efram , Kikuchi Yoshiyuki
Published: February 2024

This special issue focuses on the complex cultural connections between Japanese and British science in the nineteenth century. This was a period when intellectuals around the globe began to interact more intensively due to increased opportunities to travel and the growth in translations of important scientific works into many languages. This was also an era when, in the latter part of the century, Japanese intellectuals were searching for ways to modernize their culture, while in Britain there was a renewed interest in Japanese culture and religion as traditional forms of thought were being questioned. Although there has been some excellent scholarly work on the impact of British evolutionary theory on Japanese intellectuals, the fuller picture of cultural exchange across all the sciences has yet to be undertaken. This special issue will begin to close this historiographical gap by examining the intersection of nineteenth-century Japanese and British science across a range of disciplines from engineering, chemistry and physics to biology, sociology and anthropology.
Chitiniphilus purpureus sp. nov., a novel chitin-degrading bacterium isolated from crawfish pond sediment
Authors: Li Kaiyang , Luo Xiong , Fan Rongrong , Ding Zhuoran , Zheng Shixue , Chen Zhengjun
Published: February 2024

A novel Gram-stain-negative, curved rod-shaped, motile and chitin-degrading strain, designated CD1T, was isolated from crawfish pond sediment in Caidian District (30° 58′ N 114° 03′ E), Wuhan City, Hubei Province, PR China. Growth of this strain was observed at 15–40°C (optimum between 28 and 30 °C), at pH 7.0–9.0 (optimum between pH 7.0 and 8.0) and with 0–1 % (w/v) NaCl (optimum at 0 %). With respect to the 16S rRNA gene sequences, strain CD1T had the highest similarity (96.91–97.25 %) to four type strains of the genera ‘Chitinolyticbacter’ and Chitiniphilus within the family Chitinibacteraceae. The phylogenetic trees based on genome sequences and 16S rRNA gene sequences indicated that strain CD1T was close to members of these two genera, in particular to the genus Chitiniphilus. The genomic DNA G+C content of strain CD1T was 64.8 mol%. The average nucleotide identity and the Genome-to-Genome Distance Calculator results showed low relatedness (below 95 and 70 %, respectively) between strain CD1T and the closely related type strains. Ubiquinone-8 was the predominant quinone. The major cellular fatty acids were C10 : 0, C16 : 0, summed feature 3 (C16 : 1 ω7c and/or C16 : 1 ω6c) and summed feature 8 (C18 : 1
 ω7c and/or C18 : 1
 ω6c). The polar lipid profile was composed of a mixture of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, four unidentified lipids, two unidentified phospholipids, two unidentified aminolipids and an unidentified aminoglycolipid. On the basis of the evidences presented in this study, strain CD1T represents a novel species of the genus Chitiniphilus, for which the name Chitiniphilus purpureus sp. nov. is proposed, with strain CD1T (=CCTCC AB 2022395T=KCTC 92850T) as the type strain.
ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline
Authors: Alavattam Kris G. , Esparza Jasmine M. , Hu Mengwen , Shimada Ryuki , Kohrs Anna R. , Abe Hironori , Munakata Yasuhisa , Otsuka Kai , Yoshimura Saori , Kitamura Yuka , Yeh Yu-Han , Hu Yueh-Chiang , Kim Jihye , Andreassen Paul R. , Ishiguro Kei-ichiro , Namekawa Satoshi H.
Published: February 2024

H3K9 trimethylation (H3K9me3) plays emerging roles in gene regulation, beyond its accumulation on pericentric constitutive heterochromatin. It remains a mystery why and how H3K9me3 undergoes dynamic regulation in male meiosis. Here, we identify a novel, critical regulator of H3K9 methylation and spermatogenic heterochromatin organization: the germline-specific protein ATF7IP2 (MCAF2). We show that in male meiosis, ATF7IP2 amasses on autosomal and X-pericentric heterochromatin, spreads through the entirety of the sex chromosomes, and accumulates on thousands of autosomal promoters and retrotransposon loci. On the sex chromosomes, which undergo meiotic sex chromosome inactivation (MSCI), the DNA damage response pathway recruits ATF7IP2 to X-pericentric heterochromatin, where it facilitates the recruitment of SETDB1, a histone methyltransferase that catalyzes H3K9me3. In the absence of ATF7IP2, male germ cells are arrested in meiotic prophase I. Analyses of ATF7IP2-deficient meiosis reveal the protein's essential roles in the maintenance of MSCI, suppression of retrotransposons, and global up-regulation of autosomal genes. We propose that ATF7IP2 is a downstream effector of the DDR pathway in meiosis that coordinates the organization of heterochromatin and gene regulation through the spatial regulation of SETDB1-mediated H3K9me3 deposition.
False vacuum decay rates, more precisely
Authors: Ai Wen-Yuan , Alexandre Jean , Sarkar Sarben
Published: February 2024

We develop a method for accurately calculating vacuum decay rates beyond the thin-wall regime in pure scalar field theory at the one-loop level of the effective action. It accounts for radiative effects resulting from quantum corrections to the classical bounce, including gradient effects stemming from the inhomogeneity of the bounce background. To achieve this, it is necessary to compute not only the functional determinant of the fluctuation operator in the background of the classical bounce but also its functional derivative evaluated at the classical bounce. The former is efficiently calculated using the Gel’fand-Yaglom method. We illustrate how the latter can also be calculated with the same method, combined with a computation of various Green’s functions.

Published by the American Physical Society
2024
The missing link in the sustainability chain: Gulf women
Authors: Fadhel Shareefa
Published: February 2024

Purpose

This paper offers a unique perspective on the urbanisation process in developing cities, with a particular focus on the region of the Gulf States. Beyond economic considerations, the analysis sheds light on the complex interplay of socio-cultural factors, gender dynamics and urban development. Based on the calls for human-centred approaches to rethinking urban design and management of cities require the integration of these cities’ inhabitants’ lived experiences, that impact residents’ daily lives. The focus is on the importance of women’s perspectives in the development process.

Design/methodology/approach

The paper uses a systematic literature review that builds on existing knowledge relating to urbanisation, modernisation, sustainable cities, gender and the Arabian Gulf. It uses Lefebvre’s 'right to the city' theory to understand the evolution of the Gulf Cities which is a novel approach. This adaptation offers a unique perspective on the transformations and challenges that these urban spaces face. Furthermore, it offers a firm foundation for developing advanced knowledge on the interdisciplinary nature of the topic discussed and assists in integrating empirical findings and perspectives from different resources.

Findings

The extreme levels of transformation in urbanisation in the Gulf States built cities that are no longer solely places for settlement, production and services but operate as significant influencers on the social, economic and political relations that produced design and cultural challenges. These cities became epicentres of power and politics that shaped the national visions and influenced policy. The process of inclusive and considerate urban development that the Arabian Gulf region is aiming to embark on is not a new exclusive strategy. But a process that has been implemented and tested in other urbanised areas globally.

Research limitations/implications

Very little historical urban research on the Arabian Gulf countries exists, hence, the difficulty in researching the Gulf urbanisation process or providing historical encounters of the change.

Originality/value

This paper delves into the gendered aspects of urban planning, an aspect that is frequently overlooked. It contributes to the discourse on gender inclusivity in urban spaces by focussing on Khaleeji women’s experiences, offering insights that go beyond economic considerations. The use of Lefebvre’s “right to the city” theory to understand the evolution of the Gulf Cities is a unique approach. It investigates the interaction of various factors such as economic, cultural and political influences on Gulf urban development. This adaptation offers a distinctive perspective on the transformations and challenges that these urban spaces face.
Impact of extreme rainfall shocks on the educational performance of vulnerable urban students: evidence from Brazil
Authors: Ferreira de Lima Francisca Letícia , Barbosa Rafael Barros , Benevides Alesandra , Mayorga Fernando Daniel de Oliveira
Published: February 2024

Purpose

This paper examines the impact of extreme rainfall shocks on the performance in test scores of students living near at-risk urban areas in Brazil.

Design/methodology/approach

To identify the causal effect, we consider the exogenous variation of rainfall at the municipal level conditioned on the distance from the school to risk areas and the rainfall intensity in the school months.

Findings

The results suggest that extreme precipitation shocks, defined as a shock of at least three months of high-intensity rainfall, have an adverse impact on both math and language performance. Through a heterogeneous effects analysis, we find that the impact varies by student gender, with girls being more affected. In addition, among students who study near at-risk areas, those with better previous school performance and higher socioeconomic status are more negatively affected.

Originality/value

Our results suggest that extreme weather events can increase the differences in human capital accumulation between the population living near risk areas and those living more distant from these areas.
The role of community colleges in preparing students with special and common skills for the workforce: a longitudinal case study
Authors: Gauthier Thomas
Published: February 2024

Purpose

American Community colleges are vital to the country's economic mobility and are leaders in developing and facilitating career, technical, and workforce education. This study explored employer perspectives on employees' common and specialized skills across industries in the United States.

Design/methodology/approach

Employers were profiled for one year using a case study and content analysis method. They submitted performance records for at least three employees who graduated from community college career, technical, or workforce programs.

Findings

Data revealed that overall, employees were successful at work, but employers focused on employability skills across disciplines (common skills); specialized skills employers focused on were associated with business operations and processes and seemed to be something other than industry-specific technical knowledge.

Originality/value

This article and the research it refers to constitute original work that has not been reproduced or published. The value of this article is premised on new longitudinal data, which could be used to improve and progress institutional CTE and WD programs.
Getting on board with certified public accountant evolution: re-evaluating a financial statement analysis project in light of a changing profession
Authors: Gioiosa Marie Elaine , Meegan Cathryn M. , D'Aquila Jill M.
Published: February 2024

Purpose

Given the implementation of a new Certified Public Accountant (CPA) licensure exam and the CPA Evolution Model Curriculum, accounting educators must integrate more advanced skills in their coursework. We illustrate how a commonly-used project in accounting classes, which teaches technical accounting content, can address skills and competencies identified by the Pathways Commission and the American Institute of Certified Public Accountants (AICPA) and, as a result, enhance skills all business school graduates need in the workplace.

Design/methodology/approach

We incorporate a financial statement analysis research project under a group work format in three levels of financial accounting classes. Using both quantitative and qualitative analysis, we evaluate changes in student perceptions of skills and competencies important for business graduates.

Findings

We find students perceive improvement in critical thinking, problem-solving, the ability to work with other people, their understanding of the course material, and data analysis abilities after completion of the project. We also find statistically significant increases pre-to post-project in student perceptions of their knowledge, confidence, competence, and enthusiasm with respect to accounting material.

Originality/value

We provide an example of how educators can align a commonly-used project with the CPA Evolution Model Curriculum, yet still meet the needs of non-accounting majors and prepare all students for future business careers. Group work has been studied and similar financial statement analysis projects have been implemented in the classroom for years. We contribute by not only extending and updating this research, but also by re-evaluating a project to determine whether it meets the shifting needs of a rapidly changing profession. By doing so, we answer recent researchers’ call for research in higher education that addresses employability and workplace skills.
Whose option ratios contain information about future stock prices?
Authors: Koo Bonha , Kim Ryumi
Published: February 2024

Using the next-day and next-week returns of stocks in the Korean market, we examine the association of option volume ratios – i.e. the option-to-stock (O/S) ratio, which is the total volume of put options and call options scaled by total underlying equity volume, and the put-call (P/C) ratio, which is the put volume scaled by total put and call volume – with future returns. We find that O/S ratios are positively related to future returns, but P/C ratios have no significant association with returns. We calculate individual, institutional, and foreign investors’ option ratios to determine which ratios are significantly related to future returns and find that, for all investors, higher O/S ratios predict higher future returns. The predictability of P/C depends on the investors: institutional and individual investors’ P/C ratios are not related to returns, but foreign P/C predicts negative next-day returns. For net-buying O/S ratios, institutional net-buying put-to-stock ratios consistently predict negative future returns. Institutions’ buying and selling put ratios also predict returns. In short, institutional put-to-share ratios predict future returns when we use various option ratios, but individual option ratios do not.
Land prices, digital instruments and retail performance
Authors: GuoWei Zhang
Published: February 2024

Purpose

The results indicate that land prices exert pressure on retail performance (RP) and that the enhancement of digital means has a positive effect on RP. Additionally, digital instruments (DI) play a significant moderating role in the relationship between land prices and RP.

Design/methodology/approach

This paper empirically examines the impact of land prices on RP using panel data from 239 Chinese cities between 2011 and 2022.

Findings

The use of lagged land prices as instrumental variables effectively alleviates endogeneity issues. Both two-stage least squares (2SLS) and generalized method of moments (GMM) regression results suggest that higher land prices are associated with improved RP. Further analysis reveals that the increase in land prices leads to scale effects, structural effects and technological effects, contributing to the enhancement of RP. The impact of land prices on RP becomes more pronounced in larger cities and economically developed regions experience the pressure from land prices earlier.

Originality/value

The findings of this study have practical implications for discussions on retail industry development, site selection for retail businesses and the establishment of sustainable mechanisms for expanding domestic demand.
Craft representation network and innovative heritage: the Forbidden City’s cultural and creative products in a complex perspective
Authors: Feng Xin , Yu Lei , Tu Weilong , Chen Guoqiang
Published: February 2024

Purpose

With the development of science and technology, more creators are trying to use new crafts to represent the cultural trends of the social media era, which makes cultural heritage innovative and new genres emerge. This compels the academic community to examine craft from a new perspective. It is very helpful to understand the hidden representational structure of craft more deeply and improve the craft innovation system of cultural and creative products that we deconstruct the craft based on Complex Network and discover its intrinsic connections.

Design/methodology/approach

The research crawled and cleaned the craft information of the top 20% products on the Forbidden City’s cultural and creative products online and then performed Complex Network modeling, constructed three craft representation networks among function, material and technique, quantified and analyzed the inner connections and network structure of the craft elements, and then analyzed the cultural inheritance and innovation embedded in the craft representation networks.

Findings

The three dichotomous craft representation networks constructed by combining function, material and technique: (1) the network density is low and none of them has small-world characteristics, indicating that the innovative heritage of the craft elements in the Forbidden City’s cultural and creative products is at the stage of continuous exploration and development, and multiple coupling innovation is still insufficient; (2) all have scale-free characteristics and there is still a certain degree of community structure within each network, indicating that the coupling innovation of craft elements of the Forbidden City’s cultural and creative products is seriously uneven, with some specific “grammatical combinations” and an Island Effect in the network structure; (3) the craft elements with high network centrality emphasize the characteristics of decorative culture and design for the masses, as well as the pursuit of production efficiency and economic benefits, which represent the aesthetic purport of contemporary Chinese society and the ideological trend of production and life.

Originality/value

The Forbidden City’s cultural and creative products should continue to develop and enrich the multi-coupling innovation of craft elements, clarify and continue their own brand unique craft genes, and make full use of the network important nodes role.
Applying the third-place concept for transitional spaces in the Korean university using the design charrette approach
Authors: Durrani Sabeen Mehmood , Kim Suk-Kyung , Madill Holly
Published: February 2024

Purpose

This research investigates the impact of the COVID-19 pandemic on the use of transitional spaces in a Korean academic setting, to assess the impact of the pandemic on users' utilization of transitional spaces and evaluate any changes in their usage patterns. The research explores whether transitional spaces can function as social interactive spaces, aligning with Ray Oldenburg's “third-place” theory. The focus is on South Korean academic settings, aiming to create neutral and safe zones for users.

Design/methodology/approach

The adopted methodology involves reviewing the literature and employing design charrette as a major data collection tool. The design charrette provided a platform for users to share insights on current transitional spaces during the pandemic and envision these spaces as future social and interactive spaces.

Findings

The design charrette participants advocated for modifying the current transitional space design to transform these spaces into shared spaces for both visitors and regular users in the future. Restricting access for external users to the main building area until necessary. The significance of site amenities in determining transitional spaces as “third-places” was emphasized. While the nature of the building, its location and transitional space amenities are crucial aspects to consider, designers may prioritize user opinions and preferences, as the success or failure of the design ultimately centers on user behaviors.

Research limitations/implications

The research focused on a specific university, hindered by limited access to other institutions during the pandemic. Restrictions on external users discouraged entry without proper permission, which was challenging to obtain. The conventional design charrette outlined in the research method was impossible due to pandemic-related limitations on gathering participants in one location. Therefore, the researcher modified the design charrette method to align with strict social distancing measures.

Social implications

The results of the research are not limited to academic settings, but they can be implied in other environments where social interaction spaces are required and where there is a constant flow of visitors and regular users. The design charrette can be used as a methodology for interior spaces along with large-scale projects of urban planning.

Originality/value

The research analyzed transitional spaces during the pandemic, suggesting redesign to serve and act as buffer zones between private and public areas and become a common social gathering place for visitors and regular users within the built environment.
Needs assessment of police pre-deployment training for dispatch experts in international development cooperation of policing
Authors: Jeong Junseon , Park Minji , Jo Hyeonah , Kim Chunju , Song Ji Hoon
Published: February 2024

Purpose

This study identifies the policing pre-deployment training content for Korean experts based on needs assessments. Korean policing is at an excellent level to transfer knowledge and skills. Pre-deployment training should be designed systematically and training of trainers approaches should be implemented.

Design/methodology/approach

This study used T-tests, Borich needs assessments, and Locus for Focus model analyses to determine the priorities of needs for pre-deployment training in policing. A survey of 116 experienced experts was conducted, with 87 responding (75%).

Findings

The study identified 26 factors that deployed law enforcement professionals want to learn from pre-deployment training. These factors were categorized into three areas: research, training design and methods and understanding of partner countries and international development cooperation. The nine highest priorities for training needs were related to understanding the status and conditions of police training in the country to which policing experts are deployed.

Research limitations/implications

This study was limited to Korean policing experts. And the study did not evaluate the validity of the training curriculum or indicators.

Practical implications

Technical assistance in international policing development cooperation aims to train future trainers who can train local police. This study found that limited learner information and poor communication skills can lead to ineffective technical assistance.

Originality/value

This study highlights the importance of knowledge transfer and effective pre-deployment training for policing. The findings can be used to improve training programs and police human resource development.
Application of fuzzy logic in multi-sensor-based health service robot for condition monitoring during pandemic situations
Authors: Rout Amruta , Mahanta Golak Bihari , Biswal Bibhuti Bhusan , T. Renin Francy , Vardhan Raj Sri , B.B.V.L. Deepak
Published: February 2024

Purpose

The purpose of this study is to plan and develop a cost-effective health-care robot for assisting and observing the patients in an accurate and effective way during pandemic situation like COVID-19. The purposed research work can help in better management of pandemic situations in rural areas as well as developing countries where medical facility is not easily available.

Design/methodology/approach

It becomes very difficult for the medical staff to have a continuous check on patient’s condition in terms of symptoms and critical parameters during pandemic situations. For dealing with these situations, a service mobile robot with multiple sensors for measuring patients bodily indicators has been proposed and the prototype for the same has been developed that can monitor and aid the patient using the robotic arm. The fuzzy controller has also been incorporated with the mobile robot through which decisions on patient monitoring can be taken automatically. Mamdani implication method has been utilized for formulating mathematical expression of M number of “if and then condition based rules” with defined input Xj (j = 1, 2, ………. s), and output yi. The inputs and output variables are formed by the membership functions µAij(xj) and µCi(yi) to execute the Fuzzy Inference System controller. Here, Aij and Ci are the developed fuzzy sets.

Findings

The fuzzy-based prediction model has been tested with the output of medicines for the initial 27 runs and was validated by the correlation of predicted and actual values. The correlation coefficient has been found to be 0.989 with a mean square error value of 0.000174, signifying a strong relationship between the predicted values and the actual values. The proposed research work can handle multiple tasks like online consulting, continuous patient condition monitoring in general wards and ICUs, telemedicine services, hospital waste disposal and providing service to patients at regular time intervals.

Originality/value

The novelty of the proposed research work lies in the integration of artificial intelligence techniques like fuzzy logic with the multi-sensor-based service robot for easy decision-making and continuous patient monitoring in hospitals in rural areas and to reduce the work stress on medical staff during pandemic situation.
Urbanization drives biotic homogenization of the avian community in China
Authors: DENG Jiewen , ZHU Younan , LUO Yuelong , ZHONG Yongjing , TU Jiahao , YU Jiehua , HE Jiekun
Published: February 2024

Urbanization‐driven biotic homogenization has been recorded in various ecosystems on local and global scales; however, it is largely unexplored in developing countries. Empirical studies on different taxa and bioregions show conflicting results (i.e. biotic homogenization vs. biotic differentiation); the extent to which the community composition changes in response to anthropogenic disturbances and the factors governing this process, therefore, require elucidation. Here, we used a compiled database of 760 bird species in China to quantify the multiple‐site β‐diversity and fitted distance decay in pairwise β‐diversities between natural and urban assemblages to assess whether urbanization had driven biotic homogenization. We used generalized dissimilarity models (GDM) to elucidate the roles of spatial and environmental factors in avian community dissimilarities before and after urbanization. The multiple‐site β‐diversities among urban assemblages were markedly lower than those among natural assemblages, and the distance decays in pairwise similarities in natural assemblages were more rapid. These results were consistent among taxonomic, phylogenetic, and functional aspects, supporting a general biotic homogenization driven by urbanization. The GDM results indicated that geographical distance and temperature were the dominant predictors of avian community dissimilarity. However, the contribution of geographical distance and climatic factors decreased in explaining compositional dissimilarities in urban assemblages. Geographical and environmental distances accounted for much lower variations in compositional dissimilarities in urban than in natural assemblages, implying a potential risk of uncertainty in model predictions under further climate change and anthropogenic disturbances. Our study concludes that taxonomic, phylogenetic, and functional dimensions elucidate urbanization‐driven biotic homogenization in China.
Bacterial surface display of human lectins in Escherichia coli
Authors: Vázquez‐Arias Alba , Vázquez‐Iglesias Lorena , Pérez‐Juste Ignacio , Pérez‐Juste Jorge , Pastoriza‐Santos Isabel , Bodelon Gustavo
Published: February 2024

Lectin‐glycan interactions sustain fundamental biological processes involved in development and disease. Owing to their unique sugar‐binding properties, lectins have great potential in glycobiology and biomedicine. However, their relatively low affinities and broad specificities pose a significant challenge when used as analytical reagents. New approaches for expression and engineering of lectins are in demand to overcome current limitations. Herein, we report the application of bacterial display for the expression of human galectin‐3 and mannose‐binding lectin in Escherichia coli. The analysis of the cell surface expression and binding activity of the surface‐displayed lectins, including point and deletion mutants, in combination with molecular dynamics simulation, demonstrate the robustness and suitability of this approach. Furthermore, the display of functional mannose‐binding lectin in the bacterial surface proved the feasibility of this method for disulfide bond‐containing lectins. This work establishes for the first time bacterial display as an efficient means for the expression and engineering of human lectins, thereby increasing the available toolbox for glycobiology research.
Climate change affects the spread of typhoid pathogens
Authors: Jia Chenghao , Cao Qianzhe , Wang Zining , van den Dool Annemieke , Yue Min
Published: February 2024

Typhoid fever is caused by Salmonella enterica serotype Typhi (Salmonella Typhi). Syndromes in patients vary from asymptomatic carriers to severe or death outcomes, which are frequently reported in African and Southeast Asian countries. It is one of the most common waterborne transmission agents, whose transmission is likely impacted by climate change. Here, we claimed the evidence and consequences of climate‐related foodborne and waterborne diseases have increased and provided possible mitigations against Typhoidal Salmonella dissemination.
Mechanism of action of adapalene for treating EGFR‐TKI‐induced skin disorder
Authors: Mimura Chihiro , Nagano Tatsuya , Miwa Nanako , Matsumura Kanoko , Yamada Jun , Satoh Hiroki , Suraya Ratoe , Hazama Daisuke , Tamura Daisuke , Yamamoto Masatsugu , Tachihara Motoko , Nishimura Yoshihiro , Kobayashi Kazuyuki
Published: February 2024

Background

Skin disorders are the most common side effect associated with epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) therapy. It is important to manage skin lesions. Adapalene has been used to treat skin lesions caused by EGFR‐TKIs in some cases. The aim of this study was to investigate the functional mechanism of adapalene in erlotinib‐induced skin disorder.

Methods

To analyze the effect of adapalene on skin rash, afatinib and adapalene were administered to mice. The relationship between the concentration of adapalene and skin disorders was also examined by analyzing AQP3 expression. A skin lesion model was experimentally established in human skin keratinocytes (HaCaT) by using erlotinib with TNF‐α and IL‐1β. We used qRT–PCR to analyze chemokine‐induced inflammation and western blotting to analyze the effects of adapalene on the NF‐κB signaling pathway. Antimicrobial peptides and adhesion factors were also examined using qRT–PCR.

Results

Mice administered 0.01% adapalene had less skin inflammation than mice treated with afatinib alone. The expression level of AQP3 decreased in an adapalene concentration‐dependent manner. The mRNA levels of proinflammatory cytokines such as CCL2 and CCL27 in HaCaT cells were significantly reduced by adapalene. The expression of an antimicrobial peptide, hBD3, was upregulated after adapalene treatment. Adhesion factors, such as E‐cadherin, were significantly downregulated by EGFR‐TKI and significantly upregulated by adapalene treatment. Western blot analysis suggested that erlotinib‐induced phosphorylation of p65 was decreased by adapalene.

Conclusion

We suggest that adapalene may be a possible treatment option for skin disorders induced by EGFR‐TKIs.
Early exposure to cannabis and bipolar disorder incidence: Findings from a 22‐year birth cohort study in Brazil
Authors: Jorge Alan Cristian Rodrigues , Montezano Bruno Braga , de Aguiar Kyara Rodrigues , Noronha Lucas Tavares , Baldez Daniel Prates , Watts Devon , Menezes Ana Maria Baptista , Wehrmeister Fernando C. , Gonçalves Helen , Kunz Maurício , Kapczinski Flávio , Passos Ives Cavalcante
Published: February 2024

Background and Objectives

Bipolar disorder is a chronic condition affecting millions of people worldwide. Currently, there is some evidence to suggest that cannabis use during adolescence may be an environmental risk factor for its onset, however inconsistencies have been observed across the literature. Considering this, we aimed to assess whether early lifetime cannabis is associated with subsequent bipolar disorder in young adults between 18 and 22 years of age.

Methods

Using data from the 1993 Pelotas (Brazil) birth cohort (n = 5249), cannabis exposure was examined at age 18 by self‐report, and bipolar disorder diagnosis was measured at age 22 using the Mini International Neuropsychiatric Interview (MINI). In order to control the analysis, we considered socioeconomic status index, sex, skin color, physical abuse by parents and lifetime cocaine use.

Results

A total of 3781 individuals were evaluated in 2015 aged 22 years, of whom 87 were diagnosed with the bipolar disorder onset after the age of 18. Lifetime cannabis use predicted bipolar disorder onset at 22 years old (OR 1.82, 95% CI [1.10, 2.93]), and the effect remained after adjusting for socioeconomic status, sex, skin color, and physical abuse by parents (OR 2.00, 95% CI [1.20, 3.25]). However, this association was attenuated to statistically non‐significant after further adjustment for all available covariates, including lifetime cocaine use (OR 1.79, 95% CI [0.95, 3.19]). We also found similar results for early cocaine use, where the association with bipolar disorder onset did not maintain significance in the multivariate model (OR 1.35, 95% CI [0.62, 2.86]). Otherwise, when we considered cannabis or cocaine lifetime use as a unique feature, our findings showed that the adolescent exposure to cannabis or cocaine increased the odds by 1.95 times of developing bipolar disorder at 22 years age, even when controlling for all other study variables (OR 2.14, 95% CI [1.30, 3.47]). Finally, our models suggest that cocaine use may potentially exert a major influence on the effect of lifetime cannabis use on bipolar disorder onset, and that physical abuse by parents and sex may modify the effect of cannabis use for later bipolar disorder onset.

Conclusion

Based on our findings, early cannabis exposure predicted bipolar disorder onset in young adults, but this association was confounded by cocaine use. Contrary to schizophrenia, cannabis as a sole exposure was not associated with bipolar disorder onset after adjusting for control variables.
Novel mating behaviours in male tuatara (Sphenodon punctatus) expand our understanding of reptile courtship
Authors: Lamar Sarah K. , Ormsby Diane K. , Nelson Nicola J.
Published: February 2024

Observations of reptile courting and mating behaviour are relatively scant in the literature. Here, using the largest sample of observed courting attempts and matings in tuatara (Sphenodon punctatus) ever published, we describe novel behaviours in this rare species: mirrored head bobbing between courting pairs, purring vocalizations by displaying males, and several potential instances of anejaculation in otherwise normal matings. These results highlight the complexity of reptile mating displays and have implications for how we manage this vulnerable species.
Biomarkers associated with cardiovascular disease in women with spontaneous preterm birth: A case–control study
Authors: Cederlöf Elin Täufer , Lager Susanne , Larsson Anders , Sundström Poromaa Inger , Lindahl Bertil , Wikström Anna‐Karin , Christersson Christina
Published: February 2024

Introduction

Women with spontaneous preterm birth have an increased risk of cardiovascular disease later in life. Studies suggest potential pathophysiological mechanisms in common, but whether these could be identified by measurement of soluble circulating protein biomarkers in women with spontaneous preterm birth is unknown. The aim of this study was to determine if protein biomarkers associated with cardiovascular disease distinguish women with spontaneous preterm birth from healthy controls, both at pregnancy and at follow up.

Material and methods

Study participants were identified in the population‐based Uppsala biobank of pregnant women in Sweden, where plasma samples were collected in mid‐pregnancy. In a first screening phase, we identified participants who subsequently experienced spontaneous preterm birth (<37 weeks) in the index pregnancy (N = 13) and controls (N = 6). In these samples, differences in protein expression were examined by comparative mass spectrometry. In a second validation phase, we invited 100 cases with previous spontaneous preterm birth in the index pregnancy and 100 controls (matched for age, body mass index, and year of delivery) from the same source population, to a follow‐up visit 4–15 years after pregnancy. At follow up, we collected plasma samples and data on cardiovascular risk factors. We measured concentrations of selected biomarkers identified in the screening phase, as well as lipid profiles in samples both from pregnancy (biobank) and follow up. ClinicalTrials.gov registration NCT05693285.

Results

In the screening phase, fibrinogen, cadherin‐5, complement C5, factor XII, plasma kallikrein, apolipoprotein M, and vitamin D‐binding protein differed significantly at pregnancy. In the validation phase, 65 women agreed to participate (35 cases and 30 controls), with a median follow‐up time of 11.8 years since pregnancy. The concentration of fibrinogen (p = 0.02) and triglycerides (p = 0.03) were slightly higher in cases compared with matched controls at follow up.

Conclusions

Compared with women without preterm birth, those with spontaneous preterm birth had slightly higher concentrations of fibrinogen, both at mid‐pregnancy and a decade after pregnancy. Additionally, we found slightly higher concentration of triglycerides at follow up in women with previous spontaneous preterm birth. The relevance of this finding is uncertain but might indicate potential pathophysiological mechanisms in common between spontaneous preterm birth and cardiovascular disease.
From mindreading to originality: Exploring the relationship between Theory of Mind and Creativity across the lifespan
Authors: Beloyianni Vassiliki , Zbainos Dimitrios , Karagianni Maria‐Paraskevi
Published: February 2024

In the previous psychoeducational literature, many theorists have argued that creativity and originality require the ability to make predictions and assumptions regarding other individuals' ideas. Thus, it has been widely hypothesized that social cognition and theory of mind (ToM) might be a fundamental component or even a prerequisite of creativity. Despite their common grounds, the empirical evidence examining the potential link between ToM and creative thinking throughout their development seems to be indirect, limited, and fragmented. In this respect, this scoping review aimed to collect and synthesize the existing knowledge about the relationship between ToM and creativity at different ages to identify significant literature gaps and generate updated research questions that might guide future research. The search process led to the inclusion, analysis, and collation of 6 relevant studies only, indicating that this research topic has been poorly investigated. Results demonstrated that ToM and creativity are strongly correlated even after partialling out significant mediators, such as age and intelligence. Such a strong association should be further investigated and explained.
Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos
Authors: Umeda Koto , Tanaka Kaiho , Chowdhury Gazlima , Nasu Kouhei , Kuroyanagi Yuri , Yamasu Kyo
Published: February 2024

The vertebrate telencephalic lobes consist of the pallium (dorsal) and subpallium (ventral). The subpallium gives rise to the basal ganglia, encompassing the pallidum and striatum. The development of this region is believed to depend on Foxg1/Foxg1a functions in both mice and zebrafish. This study aims to elucidate the genetic regulatory network controlled by foxg1a in subpallium development using zebrafish as a model. The expression gradient of foxg1a within the developing telencephalon was examined semi‐quantitatively in initial investigations. Utilizing the CRISPR/Cas9 technique, we subsequently established a foxg1a mutant line and observed the resultant phenotypes. Morphological assessment revealed that foxg1a mutants exhibit a thin telencephalon together with a misshapen preoptic area (POA). Notably, accumulation of apoptotic cells was identified in this region. In mutants at 24 h postfertilization, the expression of pallium markers expanded ventrally, while that of subpallium markers was markedly suppressed. Concurrently, the expression of fgf8a, vax2, and six3b was shifted ventrally, causing anomalous expression in regions typical of POA formation in wild‐type embryos. Consequently, the foxg1a mutation led to expansion of the pallium and disrupted the subpallium and POA. This highlights a pivotal role of foxg1a in directing the dorsoventral patterning of the telencephalon, particularly in subpallium differentiation, mirroring observations in mice. Additionally, reduced expression of neural progenitor maintenance genes was detected in mutants, suggesting the necessity of foxg1a in preserving neural progenitors. Collectively, these findings underscore evolutionarily conserved functions of foxg1 in the development of the subpallium in vertebrate embryos.