bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing Maternal Fatigue During Childbirth: A Systematic Review
Authors: Chaisitsanguan Kunnikar , Kongwattananon Puangpaka , Hawthrone Dawn
Published: August 2022

Background:

Fatigue is a complex phenomenon. It is a common problem that occurs at
all periods of childbearing. Pregnancy and labor are recognized as a normal physiological process,
and fatigue, a common symptom that occurs frequently throughout the childbearing experience, has
the potential to negatively affect the woman’s prenatal and birth experience. Fatigue is often overlooked
by health professionals.

Objective:

The aim of this systematic review is to review the literature regarding the factors influencing
maternal fatigue during childbirth and its management.

Methods:

The Joanna Briggs Institute (JBI) systematic review was used to guide this study. Preferred
Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was performed to report
this systematic review. The database was searched from CINALH, Pubmed, PsyInfo, ThaiJO,
and other sources for grey literature from 1990-2021. The methodological quality process used the
critical appraisal tool for RCT study and MINORS (Methodological Index for Non-randomized
Studies). Nine published articles were selected for this study.

Results:

The factors influencing maternal fatigue during childbirth were found to be physiological,
psychological, and situational. The physiological factors were age, parity, uterine contractility,
available energy substrate, nutrition adequacy, and prenatal exercise. The psychological factors
were pain and anxiety. The situational factors were childbirth education, pain medication, prenatal
employment, sleep, breathing technique, and pushing intervention. The strategies of managing fatigue
during childbirth were 1) assessing maternal fatigue in early pregnancy; 2) childbirth preparation; 3)
conservation of energy; 4) shortened duration of labor; and 5) reduced labor pain and anxiety.

Conclusion:

Maternal fatigue during childbirth impacts the mother, the child, and the family. It is
important for nurses to understand the deleterious effects of fatigue on childbearing women and to
promote interventions that reduce or prevent fatigue during pregnancy and childbirth.
Design Synthesis and in vitro Evaluation of Tacrine-flavone Hybrids as
Multifunctional Cholinesterase Inhibitors for Alzheimer’s Disease
Authors: Remya R. S. , Ramalakshmi N. , Nalini C.N. , Niraimathi V. , Amuthalakshmi S.
Published: August 2022

Background:

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder.
The multifactorial etiology of AD has led to the design of multitarget directed ligands (MTDL) for
AD. Tacrine an acetylcholinesterase (AChE) inhibitor was the first FDA approved drug for AD but
is discontinued due to hepatotoxicity.

Objective:

Present research focused on incorporating a flavone to the tacrine nucleus to enhance the
anti-Alzheimer’s property of the tacrine with the synergistic effect of flavone which is a very good
antioxidant. It is expected that the antioxidant property and hepatoprotective nature of flavones will
reduce the hepatotoxic side effect of tacrine.

Method:

We designed and synthesized ten flavone substituted tacrine derivatives and evaluated for
in vitro AChE and BuChE inhibitoy activity by modified Ellman’s method using eeAChE and
eqBuChE. In vitro antioxidant activity was studied by DPPH radical scavenging assay. Molecular
modeling studies were conducted in Schrodinger and AutoDock Vina with TcAChE(PDB
ID:1H23),hAChE(PDB ID:4EY7) and hBuChE(PDB ID:4TPK).

Results:

All the compounds exhibited potent inhibitory effect on AChE and BuChE with IC50 values
in μM concentration. The compounds exhibited very good antioxidant activity in DPPH radical
scavenging assay. Among the compounds the compound AF1 showed highest activity with IC50
value of 0.93 μM for AChE and 1.48 μM for BuChE and also showed significant antioxidant activity
(2.6 nM). A correlation graph was plotted for IC 50 values vs Dock score and the results are
promising with r2 values of 0.62 and 0.73 for AChE and BuChE inhibition respectively which
proved the reliability of docking approaches.

Conclusion:

The results highlighted the multifunctional nature of the novel Tacrine-Flavone hybrids
and they may be promising MTDL for AD.
Surveillance on Adverse Events Following COVISHIELD (ChAdOx1
nCoV-19) vaccination in Goa, India: An Observational Study
Authors: Jose Dhanya , Dhupdale Nitin , Cacodcar Jagadish A. , Kamat Umesh
Published: August 2022

Background:

COVISHIELD, ChAdOx1 nCoV- 19 Corona Virus Vaccine was granted
emergency use authorization (EUA) as the first vaccine in India in January 2021. Knowing what to
anticipate after vaccination will reduce vaccine hesitancy in the public. This study aimed to identify
and measure the adverse events following COVID-19 vaccination.

Materials and Methods:

A cross-sectional observational study was conducted at Goa Medical College,
starting on February 21 till May 23, 2021. A total of 418 people were enrolled. We collected
the data using the Microsoft Form and analyzed using Microsoft Excel and R-program.

Results:

Of the 418 vaccine recipients, the incidence rate of AEFI (Adverse Events Following Immunization)
was 54.31%. Fever, fatigue, and headache were the most commonly reported systemic
AEFIs. Among these, 54.7% of AEFI were mild, 42.38% were of the moderate category, and only
2.96% were of grade 3 severity. None of the AEFIs were severe enough for hospitalization. Most
of them developed symptoms within 24 hours of the first dose. Complete recovery from AEFIs
took a median time of 24 hours.

Conclusion:

Most of our study findings were consistent with the phase 1, 2/3 trials findings of
Oxford-AstraZeneca's ChAdOx1 vaccine. The AEFI symptoms were considered immune reactions
to the vaccine. The AEFIs were more common among younger individuals and females. The
chance of missing a serious adverse event like a thromboembolic phenomenon cannot be ruled out.
We observed low AEFI rates with COVISHIELD in the Indian population compared to Oxford-
AstraZeneca's ChAdOx1 vaccine in the UK-based population, which can be explained by preexisting
immunity against adenovirus in the Indian population. However, based on the study findings,
we may interpret that the COVISHIELD, Serum Institute of India, carries a good safety profile
overall.
LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus
Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects
the Progression of Intervertebral Disc Degeneration
Authors: Xu Shimin , Li Yuezhong , Zhang Junshan , Li Zhiwei
Published: August 2022

Objective::

Intervertebral disc degeneration (IDD) represents one of the leading causes of low
back pain. Research suggests the participation of LINC01116 in IDD progression. Herein, the current
study explored the underlying mechanism of LINC01116 in IDD.

Methods::

The differential expression patterns of LINC01116 in IDD and normal tissues were analyzed
using the GEO database. Human nucleus pulposus (NP) cells were provided and treated with IL-1β to
establish IDD models in vitro. LINC01116 expression was detected and intervened. Indices such as cell
proliferation, apoptosis, and extracellular matrix (ECM)-related factor expression were determined using
CCK-8 assay, flow cytometry, and Western blotting. LINC01116 sublocation was identified by means of
nuclear/cytosol fractionation assay. The binding relationships between LINC01116 and miR-9-5p and
miR-9-5p and ZIC5 were verified by bioinformatics analysis, dual-luciferase assays, RNA immunoprecipitation
(RIP) assay, and RNA-pull-down. Western blotting was conducted to measure the levels of the
Wnt pathway key factors.

Results and Discussion::

LINC01116 was highly expressed in the degenerative NP cells. Silencing of
LINC01116 critically promoted degenerative NP cell proliferation and inhibited apoptosis and ECM loss.
LINC01116 was located in the cytoplasm. In degenerative NP cell models, LINC01116 could competitively
bind to miR-9-5p to elevate ZIC5 expression. LINC01116 induced NP cell apoptosis and impeded
NP cell proliferation and ECM synthesis by inhibiting miR-9-5p and miR-9-5p targeted ZIC5. ZIC5 could
effectively increase the levels of the Wnt pathway-related factors.

Conclusion::

Silencing LINC01116 blocked its adsorption of miR-9-5p as a sponge to promote the miR-9-
5p expression and inhibit ZIC5/Wnt activation, thus impacting NP cell biological functions
Insight into the Tubulin-Targeted Anticancer Potential of Noscapine and its Structural
Analogs
Authors: Shukla Shefali , Kumar Sanjay , Sagar Bulbul , Gaur Abhay , Pandey Ekta , Gulati Shikha
Published: August 2022

Cancer is known as a notorious disease responsible for threatening millions of lives every year. Natural
products which act by disrupting the microtubule assembly and dynamics have proven to be highly successful as anticancer
agents but their high toxicity owing to lower selectivity has limited their usage. Recently, Noscapine (NOS), a
known anti-tussive, has come out to be an effective anti-tubulin candidate with far lesser toxicity. Since its first report
as an anti-mitotic agent in 1998, NOS has been extensively studied and modified by various groups of researchers to
optimize its anti-tubulin activity. In this review, the recent advancements about the potential of these therapeutic candidates
against various cancers have been compiled and analyzed for their inhibitory mechanism in distinct health conditions.
It has been observed that the non-polar substitutions (e.g., halides, aryl groups) at specific sites (9-position and
N-sites of isoquinoline ring; and modification of a methoxy group) have an enhanced effect on efficacy. The mechanistic
studies of NOS and its modified analogs have shown their inhibitory action primarily through interaction with microtubules
dynamics thus disrupting the cell-cycle and leading to apoptosis. This review highlights the latest research
in the field by providing a rich resource for the researchers to have a hands-on analysis of NOS analogs and the inhibitory
action in comparison to other microtubule disrupting anti-cancer agents. The article also documents the newer
investigations in studying the potential of noscapine analogs as possible anti-microbial and antiviral agents.
WITHDRAWN: Pathway Linking Emotional Suppression to Depression and Anxiety in Cancer Patients undergoing Chemotherapy: The Mediating
Role of Ego-strength
Authors: Heshmati Rasoul , Lo Chris , Khooy Maryam Parnian , Naseri Elaheh
Published: August 2022

This article has been withdrawn from the journal “Current Aging Science”, after noticing that it is already published in another
journal, “Journal of Mental Health and Aging (2022) Volume 6, Issue 1”. The corresponding author is requested for an explanation
of this violation. However, this paper still appears on the website of the journal "Journal of Mental Health and Aging" even
after the author’s confirmation that they have withdrawn it from that journal.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

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of their article is transferred to the publishers if and when the article is accepted for publication.
The increasing physical inactivity of teenagers aged 12-16 years old of Saint Joseph College
Authors: Gula Louie Petere , Sumayang Kevin
Published: August 2022

This study aims to identify the following factors that affect the physical inactivity of the students in saint joseph college aged 12- 16 years old. It aims to understand the impact of this crisis and how to address this pressing issue. A descriptive- survey research design was utilized to document the respondents' behavior, demographics, and experiences correlated to the questions provided. The questionnaire includes 15-item questions that seek to gather information on their basic profile, current experiences, and behavior towards physical activities. The study discovers that teenagers aged 12-16 years old are inactive in physical activities and sports due to some reasons like exposure to too much time to gadgets, whether the activity provides a fun and offers socialization, lack of motivation, occupied schedules for other matters, the covid-19 pandemic, costly sports equipment on the sports of their interest, the unavailability of playing area, and lastly health concerns. Therefore, physical inactivity only alleviates certain issues, physically, mentally, spiritually, and socially. Physical inactivity is the result of demotivated individuals, physical illiteracy, prolonged screen time, and health issues.
Synthesis of Si/SiO2 core/shell fluorescent submicron-spheres for monitoring the accumulation of colloidal silica during the growth of diatom Chaetoceros sp.
Authors: Quynh Luu Manh , Huy Hoang Van , Thien Nguyen Duy , Van Le Thi Cam , Dung Le Viet
Published: August 2022

Marine diatoms play a very crucial role in carbon export, and current food-web and become an important factor in global silica cycle. This then has made the mechanism of their biosilicification interesting to be a research subject. The classical theory states that the silica metabolism has been originated from the absorption of silicate ions, which might not give a suitable explanation for the solid silica silicification. In this study, mono-disperse Si/SiO2 fluorescent submicron-spheres were synthesized in aqueous solution, and applied in monitoring the extracellular solid silica accumulation of Chaetoceros sp. diatom. The Si/SiO2 submicron particles emitted light-blue color with the spectrum centered at 440 nm under the excitation of 365 nm UV light, similar to the typical excitation/emission pair of the DAPI fluorophore (excitation/emission: 358 nm/461 nm).  The fluorescence-microscopic investigation showed that the Si/SiO2 particles delocalized on the diatoms’ surface and increased a silicic-acid-level surrounding the microalgae. As a consequence, the growth rate of the diatoms increased as the concentration of the SiO2 particles was at 120 mg/L, and reached 1.5 times higher than the growth rate calculated from the F2 media. The study not only introduces a new aspect to the extracellular metabolism of microalgae biosilicification corresponding to the global silica cycle, but also presents a new-type of culturing media using SiO2 nanoparticles for diatom cultivation, which increases the growth rate of artificial diatom-culturing for further applications.
A review of measurement of electromagnetic emission in electronic product: Techniques and challenges
Authors: Yuwono Tito , Baharuddin Mohd Hafiz , Misran Norbahiah , Ismail Mahamod , Mansor Mohd Fais
Published: August 2022

Nowadays, electronic products are being used extensively in many fields and applications. The dense population of electronic devices in human life has become a challenge for microwave engineers to ensure that their products can meet the Electromagnetic Compatibility (EMC) standards. Complex electronic products with smaller sizes and denser components will be a challenge for compliance with EMC standards. In addition, the occurrence of non-stationary emission at certain operating modes becomes a challenge for analysis. Error in analyzing EM emissions will make the products unable to meet the requirements of EMC standards; hence, they will be prohibited to be marketed. Currently, there are two methods of emission analysis, i.e. by measurement and modeling or computation. There are some problems, however, in the analysis of EM emissions regarding the area of test, complexity, DUT positioning error, installation cost, and time consumption. In this paper, the analysis techniques for EM emissions including Open Area Test Site (OATS), Anechoic chamber, Transverse Electromagnetics TEM Cell, Compact Antenna Test Range (CATR) and near field scanning are reviewed comprehensively. This survey covered EMC standards, principles of EM emission measurement techniques, advantages and disadvantages of EM emission measurement techniques, studies and applications of each technique, recommendations for which technique to be used, and challenges for future research in EM emission measurement. The final section of this paper discusses the challenges for near-field measurements related to the non-stationary emissions phenomenon. This papers also presents the challenges of how to detect and characterize them.
A Smartphone Intervention to Promote a Sustainable Healthy Diet: Protocol for a Pilot Study (Preprint)
Authors: Fresán Ujué , Bernard Paquito , Fabregues Sergi , Boronat Anna , Araújo-Soares Vera , König Laura M , Chevance Guillaume
Published: August 2022

BACKGROUND

Changing current dietary patterns into sustainable healthy diets (ie, healthy diets with low environmental impact and socioeconomic fairness) is urgent. So far, few eating behavior change interventions have addressed all the dimensions of sustainable healthy diets at once and used cutting-edge methods from the field of digital health behavior change.

OBJECTIVE

The primary objectives of this pilot study were to assess the feasibility and effectiveness of an individual behavior change intervention toward the adoption of a more environmentally sustainable healthy diet as a whole and changes in specific relevant food groups, food waste, and obtaining food from fair sources. The secondary objectives included the identification of mechanisms of action that potentially mediate the effect of the intervention on behaviors, identification of potential spillover effects and covariations among different food outcomes, and identification of the role of socioeconomic status in behavior changes.

METHODS

We will run a series of ABA n-of-1 trials over a year, with the first A phase corresponding to a 2-week baseline evaluation, the B phase to a 22-week intervention, and the second A phase to a 24-week postintervention follow-up. We plan to enroll 21 participants from low, middle, and high socioeconomic statuses, with 7 from each socioeconomic group. The intervention will involve sending text messages and providing brief individualized web-based feedback sessions based on regular app-based assessments of eating behavior. The text messages will contain brief educational messages on human health and the environmental and socioeconomic effects of dietary choices; motivational messages to encourage the adoption of sustainable healthy diets by participants, providing tips to achieve their own behavioral goals; or links to recipes. Both quantitative and qualitative data will be collected. Quantitative data (eg, on eating behaviors and motivation) will be collected through self-reported questionnaires on several weekly bursts spread through the study. Qualitative data will be collected through 3 individual semistructured interviews before the intervention period, at the end of the intervention period, and at the end of the study. Analyses will be performed at both the individual and group levels depending on the outcome and objective.

RESULTS

The first participants were recruited in October 2022. The final results are expected by October 2023.

CONCLUSIONS

The results of this pilot study will be useful for designing future larger interventions on individual behavior change for sustainable healthy diets.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/41443
Robust estimation of dementia prevalence from two-phase surveys with non-responders via propensity score stratification (Preprint)
Authors: Shen Chong , Pei Minyue , Wang Xiaoxiao , Zhao Yiming , Wang Luning , Tan Jiping , Deng Ke , Li Nan
Published: August 2022

BACKGROUND

Missing data appeared in dementia cross-sectional studies. Non-responders were related to diagnosis and would lead to biased estimation of prevalence if not properly handled.

OBJECTIVE

We aimed to introduce a robust approach to estimating the prevalence under the framework of propensity score stratification, which could significantly reduce the negative impact of non-responders on prevalence estimation.

METHODS

The probability of each participant in the Chinese Veteran Clinical Research being a non-responder (i.e., propensity score) was estimated via logistic regression. All participants were divided into five strata based on their PSS. The stratum-specific prevalence of dementia was estimated by simple estimation (SE), regression estimation (RE) and multiple imputation (MI). The overall prevalence and its variance was obtained by integrating the stratum-specific prevalence.

RESULTS

The prevalence of dementia without imputation in CVCR were 9.95%. The prevalence estimation of SE, RE and MI with PSS were 12.24%, 12.28% and 12.20%, separately. It showed higher consistency to the estimation of SE, RE and MI without PSS, which were 11.64%, 12.33%, 11.98%, separately. The estimated prevalence after imputation, either with or without PSS, were higher than the prevalence without imputation in the CVCR platform. Compered the estimation with other non-imputed cross-sectional studies, the results were still higher.

CONCLUSIONS

Prevalence estimation with PSS could give a more robust and less biased result.
From testers to co-creators: the value and approaches to successful patient engagement in the development of eHealth solutions – Qualitative Expert Interviews Study (Preprint)
Authors: Jacob Christine , Bourque Steven , Heuss Sabina
Published: August 2022

BACKGROUND

Research has shown that patient engagement is most commonly done in the beginning of research or to test readily available prototypes and less commonly in other phases such as the execution phases. Previous studies report that patients usually are assigned a consultative, rather than decision-making role in health service planning and evaluation.

OBJECTIVE

The aim of this study was to better understand the challenges and opportunities in the inclusion of patients in the development of eHealth technologies, and to create a research-based end-to-end practical blueprint that can guide the relevant stakeholders to successfully engage patients as co-creators in all human-centered design phases rather than mere testers of preplanned prototypes.

METHODS

Key informant interviews were conducted, through in-depth semi-structured interviews with 20 participants in 6 countries across Europe. This was followed by a focus group to validate the initial findings. Participants encompassed all the relevant stakeholder groups including patient experts, eHealth experts, health technology providers, clinicians, pharma executives, and health insurance experts.

RESULTS

This study shows that engaging patients in eHealth development can help provide different types of value; namely identifying unmet needs, better usability and desirability, better fit into the patient journey, better adoption and stickiness, better health outcomes, advocacy and trust, sense of purpose, and better health equity and access. However, the participants agreed that patients are usually engaged too late in the development process, mostly assuming a sounding role to test a ready-made prototype. These gaps in engagement were justified by some prominent barriers, notably compliance risks, patient related factors, power dynamics, patient engagement as lip service, poor value perception, lack of resources, mistrust, and inflexibility. On the positive side, the participants also reflected on facilitators for better patient engagement; for instance, engaging through engagement partners, novel approaches such as the rise of professional patient experts, embedding patients in the development teams, expectation management, and professional moderation services.

CONCLUSIONS

Overcoming the current gaps in patient engagement in eHealth development requires consolidated efforts from all stakeholders in the complex healthcare ecosystem. The shift towards more patient-driven eHealth development requires education and awareness, frameworks to monitor and evaluate the value of patient engagement, regulatory clarity and simplification, platforms to facilitate patient access and identification, patient incentivization, transparency and trust, and a mindset shift towards a more value-based healthcare.

CLINICALTRIAL

NA
Respuesta del sistema erosivo fluvial en las cuencas Ameca y Santiago, centro-occidente de México, ante el control tectónico y volcánico
Authors: Godínez-Tamay Arturo , Castillo-Rodríguez Miguel
Published: August 2022

El volcanismo del Mioceno tardío asociado a la Faja Volcánica Trans-Mexicana modificó las rutas de transporte de sedimento proveniente del relieve del Oligoceno tardío-Mioceno temprano del centro-occidente de México. Se hipotetiza que los materiales de la Sierra Madre Occidental hubiesen llegado a la planicie aluvial del Graben de Puerto Vallarta. La actividad volcánica de la Faja Volcánica Trans-Mexicana al sur de la Sierra Madre Occidental posiblemente generó el cambio en el curso de la descarga de sedimentos provenientes de la Sierra Madre Occidental, hacia la planicie fluvial de Nayarit, a través del río Santiago. Este evento frenó el transporte de sedimentos provenientes de la Sierra Madre Occidental al Graben de Puerto Vallarta y la Bahía de Banderas y aisló una porción de relieve que actualmente corresponde a la cuenca del río Ameca, la cual suministra, hoy en día, los sedimentos que conforman la planicie fluvial del Graben de Puerto Vallarta. La distribución de edades de zircones detríticos del Oligoceno tardío al Mioceno temprano en las desembocaduras de las cuencas Santiago y Ameca, indica que ambas cuencas comparten sedimentos originados en la Sierra Madre Occidental.
On the presence of Xiphactinus (Teleostei, Ichthyodectiformes) in the Coniacian-Campanian marine deposits of the Piedritas site, Coahuila, northern Mexico
Authors: Alvarado-Ortega Jesús , Porras-Múzquiz Héctor Gerardo
Published: August 2022

The discovery of the first Mexican fossil specimen belonging to the species Xiphactinus audax is reported here. This specimen was recovered in the Coniacian-Campanian marine deposits of the Austin Group at the Piedritas site, within the homonymous ejido, Municipality of Ocampo, north of Coahuila. Although the specimen is strongly fragmentary, partially preserved by impressions or molds of the bones, and only shows parts of the head, the opercular series, and the pectoral fins, this has enough anatomical features that allow its specific taxonomic determination. Among these diagnostic features, this fossil has a well-developed ethmopalatine bone, a well-developed supraoccipital crest, a maxilla anteriorly higher than the rest of the bone, and a very robust palatine articular head. Particularly, this fossil exhibits two distinctive features of the genus Xiphactinus, a row of conical teeth, irregularly sized and distributed in the maxilla and dentary bones, as well as a pectoral radius 1 extremely developed and at least 2.5 times wider than the subsequent ray. At the same time, its teeth are smooth and have no sharp edges or carenae, which allows its specific identification. The present discovery complements the geographical distribution of Xiphactinus confirming its wide longitudinal distribution throughout America.
Effects of Functional Cognitive Gait Pattern Program on Gait Pattern and Cognitive Function in Mental Retarded Children
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Hyun Kwang-Suk , Park Jeong-Min , Kim Kyeong-Lae
Published: August 2022

Objectives The purpose of this study was to help neurological disorders seen of the children and improve their quality of life by investigating the functional cognitive gait pattern program on gait pattern and cognitive function in mental retarded children.
Methods In order to achieve the purpose of this study, 33 mental retarded children at N located in K city, were selected at random and allocated 11 mental retarded children each for the Non Exercise group (NEG), Deficient Exercise group(DEG), Over Exercise group (OEG) and measured kinematic gait pattern and cognitive function before and after the experiment. The data obtained from this study were analyzed using the SPSS 26.0 statistical program the two-way repeated measures ANOVA and Bonferroni post-hoc test was performed.
Results The conclusions obtained through this study were as follows. First, as a result of analyzing the change of gait pattern to functional cognitive gait pattern program, there were significantly improved in velocity, cadence, step length, stride length in OEG compared with NEG and DEG after 16 weeks. Second, as a result of analyzing the change of cognitive function according to functional cognitive gait pattern program, there were significantly improved in body part, number display, movement, operation in OEG compared with NEG and DEG after 16 weeks.
Conclusions As conclusions, this study confirmed that the functional cognitive gait pattern program could improve the gait pattern and cognitive function in the mental retarded children.
Analisis Perencanaan Dan Pengawasan Persediaan Minyak Kelapa Sawit Pada PT. Pacific Palmindo Industri Medan
Authors: Anggraini Ratih , Sari Purwita , Aisyah Siti , Adhiko Ridho Gilang , Fadillah Tri Dessy , Awalia Kiki
Published: August 2022

Pengendalian persediaan meliputi pengendalian fisik dan pengendalian akuntansi. Pengendalian material terutama ditujukan pada sarana penyimpanan persediaan di gudang dan pengendalian jumlah yang dibutuhkan. Sedangkan pengawasan akuntansi terkait dengan sistem pengendalian internal perusahaan. Pengendalian persediaan harus dapat memberikan informasi yang akurat kepada manajemen sehingga dapat membantu manajemen dalam proses pengambilan keputusan. Masalahnya adalah apakah teknik pengendalian persediaan cukup efektif dan efisien untuk bisnis. Data sekunder yang diperoleh dari bisnis mencakup sejarah singkat bisnis, struktur organisasinya, dan laporan inventarisnya. Jenis penelitian yang penulis pakai dalam penelitian ini yaitu pendekatan kuantitatif.Metode analisis data dalam penelitian ini adalah deskriptif. Hasil penelitian menunjukkan bahwa pelacakan persediaan minyak sawit oleh perusahaan menggunakan teknik pengendalian persediaan, baik pengendalian persediaan fisik maupun pengendalian mutu, telah diterapkan sepenuhnya. Sistem akuntansi persediaan cukup baik dalam upayanya melindungi persediaan dari penipuan dan meningkatkan keandalan dan keakuratan pencatatan akuntansi persediaan. Adanya pemisahan tugas dan tanggung jawab, sistem otorisasi yang memadai, dan pemeriksaan operasional yang independen menunjukkan bahwa perusahaan memiliki prosedur pengendalian persediaan yang benar.  
The Growth and Impact of e-Filing in Indonesia
Authors: Lubis Nurul Izzah , Susilawaty Tengku Eka , Lyanto Benny
Published: August 2022

e-Filing is an application provided by the Directorate General of Taxes to facilitate taxpayers in reporting their Annual SPT and as a support to increase state revenue from tax sector. This study aims to find out how the growth and impact of e-Filing in Indonesia over a period of 7 years, namely 2014 to 2020 and what things the government should do in order to maintain or increase the use of e-Filing as a means of receiving tax in Indonesia. This type of descriptive research is carried out with a desk study approach where both types of qualitative and quantitative data are used and taken from trusted secondary data sources. The conclusion of this research is the average percentage of e-Filing users compared to the number of registered taxpayers who are required to SPT for a period of 7 years is only 39% and that the growth of e-Filing users is indicated to decline from 2017 to 2020. In order to maintain or increase the use of e-Filing in Indonesia, government must continue to improve the quality of e-Filing in terms of ease of access, trust, environmental interaction functions, reliability, display of information content, support for users, and responsiveness to feedback, continuing socialization and counseling activities, accelerate the mandatory use of e-Filing in reporting SPT and focus on the growth of compliance ratio of each taxpayers division.
Pengaruh Kompensasi Terhadap Kinerja Karyawan Pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara
Authors: Dewi Ananda Fitriani
Published: August 2022

Tujuan penelitian adalah untuk mengetahui Pengaruh Kompensasi Terhadap Kinerja Karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara, dan manfaatnya sebagai bahan masukan dan informasi bagi perusahaan untuk merumuskan kebijakan pemasaran, sebagai bahan kajian ilmiah dari teori yang pernah didapat untuk bisa diimplementasikan secara empiris dilapangan, sebagai bahan referensi bagi penelitian selanjutnya.Data dalam penelitian diambil melalui kuesioner dengan teknik pengumpulan data menggunakan metode observasi dan studi dokumentasi. Sedangkan teknik analisis data menggunakan analisis korelasi.Hasil penelitian ini memperlihatkan bahwa pengaruh bersifat positif atau searah berarti jika kompensasi meningkat maka kinerja karyawan juga akan meningkat. Sedangkan signifikan atau nyata berarti kompensasi memang benar-benar penentu atau prediktor dari kinerja karyawan PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara. Sehingga dapat dikatakan bahwa semakin tinggi kompensasi maka kinerja karyawan juga akan meningkat. Demikian sebaliknya semakin rendah kompensasi semakin rendah kinerja karyawan yang dicapai perusahaan. Selanjutnya dapat dilihat bahwa kontribusi kompensasi terhadap kinerja karyawan PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara  sebesar 42,0%, uji t (uji hipotesis) sebesar 2,80 menunjukkan bahwa adanya pengaruh positif dan signifikan antara kinerja karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara dengan nilai 2,80 (2,80 > 1,696). Hasil koefisien determinan adalah 17,6% memiliki makna bahwa variabel kompensasi tidak memiliki hubungan yang erat terhadap kinerja karyawan pada PT. Pusri Pemasaran Pupuk Daerah (PPD) Sumatera Utara.
Deviation bounds and concentration inequalities for quantum noises
Authors: Benoist Tristan , Hänggli Lisa , Rouzé Cambyse
Published: August 2022

We provide a stochastic interpretation of non-commutative Dirichlet forms in the context of quantum filtering. For stochastic processes motivated by quantum optics experiments, we derive an optimal finite time deviation bound expressed in terms of the non-commutative Dirichlet form. Introducing and developing new non-commutative functional inequalities, we deduce concentration inequalities for these processes. Examples satisfying our bounds include tensor products of quantum Markov semigroups as well as Gibbs samplers above a threshold temperature.
A ESTRATÉGIA DA INVESTIGAÇÃO E SUA RELAÇÃO COM O ENVOLVIMENTO, INTERESSE E A PARTICIPAÇÃO DA CRIANÇA
Authors: Pozzebon Iasmin , Silva da Silva Jacqueline
Published: August 2022

Configurando-se como uma pesquisa de abordagem qualitativa, do tipo bibliográfico, o presente artigo tem como objetivo conhecer e relacionar a estratégia da investigação com o envolvimento, o interesse e a participação da criança no ambiente escolar, partindo do pressuposto de que é importante que a criança esteja conectada e envolvida no processo de aprendizagem. Dessa forma, todo o seu aprendizado e conhecimento passa a ter sentido, agregando valor e significado em sua trajetória escolar. Concluímos, a partir deste estudo, que as práticas pedagógicas, na Educação Infantil, que envolvem a estratégia da investigação promovem a participação das crianças no processo de aprendizagem.
ESTUDO DE RELAÇÕES INTERCULTURAIS AFRO-BRASILEIRAS NO ENSINO MÉDIO INTEGRADO: DOS MARCOS LEGAIS À ORGANIZAÇÃO CURRICULAR
Authors: De Sousa Pereira Cassia Maria , Porto Cavalcante Rivadavia , Gomes Silveira de Senna Mary Lúcia , Maldaner Jair José , Rythowem Marcelo
Published: August 2022

O artigo objetiva fomentar discussões sobre atualização curricular relacionando Educação Profissional e Tecnológica com Educação para relações étnico-raciais numa perspectiva humanística e intercultural. O estudo baseou-se nos aportes teóricos de estudiosos da Pedagogia histórico-crítica e de estudiosos da temática História e cultura afro-brasileira. Mediante pesquisa exploratória, revisão bibliográfica e análise documental analisou-se no recorte investigativo como esta temática, prevista em marcos legais vigentes, está organizada no Projeto Pedagógico de um Curso Técnico em Agropecuária Integrado ao Ensino Médio de um Instituto Federal da região norte brasileira. O estudo indica que a referida temática ocupa lugar periférico e exíguo no currículo, se revelando desvinculada de práticas interculturais e da formação integrada. Urge, portanto, articulação entre currículo escolar e igualdade de direitos educacionais.
O ETHOS DISCURSIVO EM CHICO BUARQUE: ENUNCIAÇÃO PROJETADA E APRECIAÇÃO SOCIAL EVOCADA
Authors: Saratt Luciana , Paschoal Cristiano Sandim
Published: August 2022

O presente artigo teve como proposição analítica o ethos discursivo que emerge das canções Apesar de você e As caravanas, de Francisco Buarque de Hollanda. Ancorando-se no quadro cênico enunciativo postulado por Dominique Maingueneau, foram destacadas as marcas linguísticas projetadas no discurso e as apreciações crítico-sociais por elas evocadas. Por fim, ao se asseverar, à luz da Análise do Discurso, que a situação extraverbal se faz imbricada na construção de sentidos no fio do discurso, observou-se que nas duas composições analisadas o musicista deu voz a enunciadores que, ao projetarem-se nos enunciados, demonstram representar minorias oprimidas durante o regime militar, bem como as diferenças sociais que permeiam a atual conjuntura social.
Doprinos Družbe „Braća Hrvatskoga Zmaja” njegovanju sjećanja na Prvi svjetski rat
Authors: Gabelica Mislav
Published: August 2022

U članku autor analizira odnos hrvatskoga kulturnog društva, Družbe „Braća Hrvatskoga Zmaja”, čija je jedna od svrha bila njegovati uspomenu na „slavne događaje iz hrvatske prošlosti i na znamenite Hrvate”, prema baštini Prvoga svjetskog rata. Pritom taj odnos promatra kroz tri vremenske faze koje su djelovale izvan ovoga društva (fazu djelovanja društva unutar Austro-Ugarske Monarhije, unutar monarhističke Jugoslavije i unutar Nezavisne Države Hrvatske) te kroz dvije faze koje su djelovale unutar društva (fazu djelovanja društva pod Emilom Laszowskim do sredine 1930-ih i fazu nakon toga). Budući da autor ovo društvo u tom razdoblju određuje kao reprezentativno hrvatsko kulturno društvo, smatra da bi njegov odnos prema baštini Prvoga svjetskog rata mogao biti i pokazatelj odnosa cjelokupne hrvatske javnosti prema tom ratu.
Health Beliefs Associated with Metformin Use Among Insured Adults with Prediabetes
Authors: McEwen Laura N. , Hurst Thomas E. , Joiner Kevin L. , Herman William H.
Published: August 2022

  

Objective: To use the framework of the Health Belief Model (HBM) to explore factors associated with metformin use among adults with prediabetes.

Research Design and Methods: We analyzed survey data from 200 metformin users and 1,277 non-metformin users with prediabetes identified from a large, insured workforce. All subjects were offered the National Diabetes Prevention Program (DPP) at no out-of-pocket cost.  We constructed bivariate and multivariate models to investigate how perceived threat, perceived benefits, self-efficacy, and cues to action impacted metformin use and how demographic, clinical, sociopsychological, and structural variables impacted the associations.

Results: Adults with prediabetes who used metformin were younger, more likely to be women, and to have worse self-rated health and higher BMIs than those with prediabetes who did not use metformin. Those who used metformin were also more likely to be aware of their prediabetes and to have a personal history of gestational diabetes or a family history of diabetes. After considering perceived threat, perceived benefits, self-efficacy, and cues to action, the only independent predictors of metformin use were younger age, female sex, higher BMI, and cues to action, most specifically, a doctor offering metformin therapy. 

Conclusions: Demographic and clinical factors and cues to action impact the likelihood of metformin use for diabetes prevention. Perceived threat, perceived benefits, and self-efficacy were not independently associated with metformin use. These results highlight the importance of patient-centered primary care and shared decision making in diabetes prevention. Clinicians should proactively offer metformin to patients with prediabetes to facilitate effective diabetes prevention. 
Evolution of Clinical Complexity, Treatment Burden, Healthcare Utilization, and Diabetes-Related Outcomes among Commercial and Medicare Advantage Beneficiaries with Diabetes in the U.S., 2006-2018
Authors: Benning Tyler J. , Heien Herbert C. , McCoy Rozalina G.
Published: August 2022

  

Objective: To characterize trends in clinical complexity, treatment burden, healthcare utilization, and diabetes-related outcomes among adults with diabetes.

Research Design and Methods: A nationwide claims database was used to identify enrollees in commercial and Medicare Advantage plans who met claims criteria for diabetes between 01/01/2006 and 03/31/2019 and to quantify annual trends in clinical complexity (e.g., active health conditions), treatment burden (e.g., medications), healthcare utilization (e.g., ambulatory, emergency department [ED], and hospital visits), and diabetes-related outcomes (e.g., hemoglobin A1c [HbA1c] levels) between 2006 and 2018. 

Results: Among 1,470,799 commercially-insured patients, the proportion with ≥10 active health conditions increased from 33.3% (95% CI 33.1%-33.4%) in 2006 to 38.9% (38.8%-39.1%) in 2018 (p=0.001), and the proportion taking ≥3 glucose-lowering medications increased from 11.6% (11.5%-11.7%) to 23.1% (22.9%-23.2%), (p=0.007). The proportion with HbA1c ≥8.0% (≥64 mmol/mol) increased from 28.0% (27.7%-28.3%) in 2006 to 30.5% (30.2%-30.7%) in 2015, decreasing to 27.8% (27.5%-28.0%) in 2018 (overall trend p=0.04). Number of ambulatory visits per patient/year decreased from 6.86 (6.84-6.88) to 6.19 (6.17-6.21), (p=0.001), while ED visits increased from 0.26 (0.257-0.263) to 0.29 (0.287-0.293), (p=0.001). Among 1,311,903 Medicare Advantage enrollees, the proportion with ≥10 active conditions increased from 51.6% (51.2%-52.0%) to 65.1% (65.0%-65.2%), (p<0.001), the proportion taking ≥3 glucose-lowering medications was stable at 16.6% (16.3%-16.9%) and 18.1% (18.0%-18.2%), (p=0.98), and the proportion with HbA1c ≥8.0% increased from 17.4% (16.7%-18.1%) to 18.6% (18.4%-18.7%), (p=0.008). Ambulatory visits per patient per year remained stable at 8.01 (7.96-8.06) and 8.17 (8.16-9.19), (p=0.23), but ED visits increased from 0.41 (0.40-0.42) to 0.66 (0.66-0.66), (p<0.001).

Conclusions: Patients with diabetes are becoming increasingly complex over time, have higher treatment burden, and experience more ED visits for potentially low acuity conditions.
Plasma exosomal microRNAs associated with metabolism as early predictor of gestational diabetes mellitus
Authors: Ye Zhixin , Wang Songzi , Huang Xiaoqing , Chen Peisong , Deng Langhui , Li Shiqi , Lin Suiwen , Wang Zilian , Liu Bin
Published: August 2022

To date, the microRNA (miRNA) expression profile of plasma exosomes in women whose pregnancy is complicated by gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs in plasma exosomes were identified by high-throughput small RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 22 exosomal miRNAs were found and five of them were verified by qRT-PCR. Exosmal miR-423-5p was upregulated, while miR-122-5p, miR-148a-3p, miR-192-5p, and miR-99a-5p were downregulated in women whose pregnancy is complicated by GDM. IGF1R and GYS1 as target genes of miR-423-5p, and G6PC3 and FDFT1 as target genes of miR-122-5p, were associated with insulin and AMPK signaling pathways and may participate in the regulation of metabolism in GDM. The five exosomal miRNAs showed an AUC of 0.82 (95%CI, 0.73~0.91) in early prediction of GDM. Our study demonstrated that dysregulated exosomal miRNAs in plasma from GDM pregnant women might influence the insulin and AMPK signaling pathways and could contribute to the early prediction of GDM. 
Principles of territory zoning as a basis for planning linear objects
Authors: Tikhonova K. V. , Kutsenko M. M. , Ozerov A. A.
Published: August 2022

Functional zoning of the territory is the basis for the effective development of the land, the place-ment of linear objects is also part of the zoning process of the territory.

This article presents the results of the analysis of the main regulatory documents necessary for the development and planning of the territory.

Linear objects are quite complex objects for the formation of documentation on them, further regis-tration and registration.

Despite the issue of preparing cadastral documentation that has been worked out from the point of view of legislation, as well as the vast practical experience of entering information about linear ob-jects both in the EGRN and in other related resources, the placement of each object is a unique process that requires additional research. This circumstance determines the relevance of the research topic.
Working design is an important task of land management (on the example of horticultural farms)
Authors: Sviridova A. D. , Vlasov A. I.
Published: August 2022

The issues of working design in land management, a set of measures for the organization and opera-tion of intensive gardens, technological and economic aspects of the formation and cultivation of perennial plantings, modern methods in the activities of fruit farms are considered.
PENGENALAN BAHASA INGGRIS BERBASIS GAME ANAK-ANAK DI PANTI ASUHAN AL BERKAH PALANGKA RAYA
Authors: Qamariah Zaitun
Published: August 2022

Pengabdian masyarakat ini bertujuan untuk untuk mendeskripsikan pembelajaran pengenalan bahasa inggris berbasis game pada anak-anak di Panti Asuhan Al Berkah Palangka Raya. Metode analisis yang digunakan pada pengabdian ini adalah metode deskriptif. Teknik pengumpulan data diperoleh melalui teknik observasi, tanya jawab, dan dokumentasi. Berdasarkan hasil pengabdian masyarakat yang dilakukan dapat disimpulkan bahwa pengenalan bahasa inggris berbasis game dilakukan dengan tahap persiapan berupa penyampaian materi dasar (berhitung dan kosakata) yang akan dikenalkan kepada anak-anak Panti Asuhan Al Berkah Palangka Raya manfaat setelah mempelajari materi tersebut pada anak, tahap inti berupa penyampaian materi dasar (berhitung dan kosakata) berbasis game pada anak, dan tahap penutup berupa evaluasi dan foto bersama anak-anak Panti Asuhan Al Berkah Palangka Raya.