bluuebunny/crossref_metadata_2025 huggingface dataset:
Agricultural Water Price Sharing
Authors: huang yulin , Luo Canxia
Published: January 2025

Quantitative research on the scale of agricultural water price sharing can enrich the theoretical research system of agricultural water price, which is highly important for guaranteeing the benign operation of irrigation areas and promoting the high-quality sustainable development of agriculture. This paper takes Xianyang city as the research area, analyzes agricultural irrigation benefits from the perspective of agricultural irrigation water utilization, defines the main body of agricultural water price sharing, constructs a value accounting model of agricultural irrigation benefits via the value quantity assessment method, explores the quantitative method of agricultural water price sharing on the basis of this method, and establishes an agricultural water price sharing model. The model is applied to Baoji Gorge Irrigation District in Xianyang city, and combined with the current agricultural water price in the irrigation district, the agricultural water price shared by farmers growing different crops in the irrigation district and the governments at all levels is obtained. The results show that the sharing coefficient of farmers who plant grain and oil crops is 0.24, the sharing price of water is 0.314 yuan/m³, the sharing coefficient of farmers who cultivate cash crops is 0.41, and the sharing price of water is 0.535 yuan/m³; the central government's sharing coefficient is 0.09, the sharing price of water is 0.116 yuan/m³, the sharing coefficient of the local government is 0.26, and the sharing price of water is 0.347 yuan/m³. The results of this study can be combined with the actual situation to provide a scientific basis for the rational development of agricultural water prices in the study area and promote the comprehensive reform of agricultural water prices in the study area.
Investigating the protective mechanism of Astragalus membranaceous (Fisch.) against cerebral ischemia-reperfusion injury in rats: A metabolomics and network pharmacology approach
Authors: Liang Ruimin , Chen Yue , Zhang Ruizhen , Wang Kai , Shu Yan , Qiao Yi , Song Fahuan , Cao Jinyi , Yang Zhifu
Published: January 2025

Astragalus membranaceous (Fisch.) has a rich history as a traditional medicine in various Asian countries, showcasing a notable neuroprotective effect. However, the underlying therapeutic mechanisms warrant further investigation. This study employs metabolomics and network pharmacological analysis to elucidate the protective effects of Radix Astragali (Huangqi, HQ) against cerebral ischemia-reperfusion injury (CI/RI) in rats. The investigation aims to reveal the potential protective mechanisms of HQ in CI/RI rats. Plasma metabolomics analysis, utilizing multivariate statistical methods, highlights biomarkers and associated metabolic pathways. The integrated approach of network pharmacology comprehensively analyzes HQ’s effective components, therapeutic targets, and amino acid metabolites. Pharmacodynamic experiments demonstrate a significant cerebral protective effect in the HQ group compared to the model group (p < 0.05). Metabolomics results indicate significant differences (P < 0.05) in L-glutamic acid, L-arginine, L-ornithine hydrochloride, L-valine, and L-phenylalanine in the model group compared to the sham operation group, indicating plasma metabolic disorders in CI/RI rats. Network pharmacology analysis identifies quercetin, kaempferol, and astragaloside IV components within HQ that may act on IL6, TNF, and IL-1B targets, influencing five different amino acids to exert brain protection. This study provides valuable insights into the neuroprotective mechanisms of HQ in the context of CI/RI.
Improved DV-HOP Localization Algorithm Based on Grey Wolf Optimization
Authors: Yang Siqi , Wang Xiaohua
Published: January 2025

DV-HOP is a widely used localization algorithm, commonly applied in areas such as node localization in Wireless Sensor Networks (WSN), deployment of Internet of Things (IoT) devices, and navigation for mobile robots. However, the DV-HOP algorithm faces challenges in practical applications, including cumulative hop count errors between nodes, inaccuracies in estimated hop distances, and computational bias introduced by the least squares method when dealing with nonlinear problems. To address these issues, this paper proposes an improved DV-HOP localization algorithm based on Grey Wolf Optimization (GWO). By incorporating dual communication radii, weighted hop distance correction, and an improved Grey Wolf Optimization algorithm (IGWO), the proposed approach enhances the localization accuracy of nodes in WSN. First, the dual communication radii strategy is utilized to refine the hop count between nodes, improving the accuracy of hop estimations. Second, a hop adjustment factor is introduced to further correct the minimum hop count between anchor nodes, resulting in more precise average hop distances. Weighted optimization of estimated hop distances from unknown nodes to anchor nodes is achieved using the minimum mean square error criterion. Finally, the improved Grey Wolf Optimization algorithm replaces the least squares method for solving the coordinates of unknown nodes. Simulation results demonstrate that the proposed improved DV-HOP algorithm consistently achieves lower localization errors under various experimental conditions. Compared with other methods, it provides higher localization accuracy, verifying its effectiveness and advantages.
Olfactory responses of sex pheromone receptors in Spodoptera litura (Lepidoptera: Noctuidae) to inter- and intra-specific sex pheromone
Authors: Zhang Yueying , Li Jiaying , Xiao Yansong , Zeng Weiai , Teng Kai , Chen Mengdan , Du Caroline , Liu Tianbo , Wu Shaolong , Du Yongjun
Published: January 2025

Spodoptera litura is an important crop pest while sex pheromone trapping has been used as a tool for S. litura population monitoring. The objective of this study was to detect olfactory responses of sex pheromone receptors in S. litura to inter- and intra- specific sex pheromone. We identified three pheromone odorant receptors (ORs) --- SlituOR13, SlituOR6 and SlituOR16. SlituOR6 had the strongest response to the minor sex pheromone component E11-14:Ac of S. litura, and weak responses to the inter-specific sex pheromone components 16:Ac and Z9-14:Ac. SlituOR13 had a strong response to the minor sex pheromone component E11-14:Ac of S. litura, and a weak response to the minor component Z9-14:Ac. SlituOR16 responded strongly to the sex pheromone component Z9-14:OH of S. exigua, had some responses to the intra-specific sex pheromone component Z9-14:Ac, Z9E11-14:Ac and Z9E12-14:Ac of S. litura, and the inter-specific sex pheromone component Z7-12:Ac of Agrotis ipsilon, but a weak response to the minor component E11-14:Ac of S. litura. Field data from sex pheromone trapping supported that Z9-14:OH and Z7-12:Ac inhibited the olfactory response of male S. litura to sex pheromones.
Results of functioning of the Federal databank of radiation doses to the population of the Russian Federation due to natural sources of ionizing radiation in 2022–2024
Authors: Kormanovskaya T. A.
Published: January 2025

The paper presents results of analysis of data accumulated during 2022–2024 in the Federal databank of radiation doses to the public from exposure to natural and technologically enhanced background radiation, which functions within the framework of the Unified State System for Monitoring and Accounting for Individual Doses of Radiation to the Citizens. The results of 598,604 measurements of ambient gamma dose rate in dwellings and public buildings and outdoors in various regions of the country, 155,249 measurements of indoor radon isotopes equilibrium equivalent concentration, 58,804 measurements of activity concentrations of natural radionuclides in drinking water were analyzed. Based on these data, a hygienic assessment of the radiation safety of the population of the Russian Federation due to exposure to natural sources of ionizing radiation in the period 2021–2023 was performed. The analysis of data on indoor radon isotopes equilibrium equivalent concentration showed that in a number of regions of Russia (the Altai Republic, the Republic of Sakha (Yakutia), the Republic of Tyva, Zabaykalsky Krai, Irkutsk Oblast, etc.), in the study period, hygienic norms (action levels) for dwellings and public buildings were exceeded. The analysis of data on activity concentrations of natural radionuclides in drinking water revealed significant (more than an order of magnitude) exceedances of the intervention level for radon in drinking water of certain sources of drinking water supply in Chelyabinsk Oblast and Zabaikalsky Krai. The assessment of public doses due to natural sources of ionizing radiation showed that in several regions of Russia (the Altai Republic, the Republic of Bashkortostan, the Republic of Tyva, Irkutsk Oblast, Stavropol Krai, etc.) public exposure to natural sources can be classified as “increased” (average annual effective dose is in the range 5–10 mSv), and in Zabaikalsky Krai public exposure can be classified as “high” (average annual effective dose exceeds 10 mSv/year) in 2021 and 2023.
Implementation of a machine learning approach to predict streamflows in watersheds: a case study of the Leaf River catchment
Authors: Rostampour Javad , Mollazadeh Mahdi , Pourreza-Bilondi Mohsen , Sahranavard Hamed
Published: January 2025

Accurate prediction of streamflows is crucial for managing water resources. Machine learning approaches have gained popularity for their ability to handle noisy and non-linear data and develop models that are capable of detecting relationships from the data they are provided with. This study was conducted to compare the performance of three machine learning algorithms (including extreme learning machine (ELM), random forest (RF), and gene expression programming (GEP)) and their hybrid versions in predicting the monthly streamflow of the Leaf River catchment. The models were tested with three scenarios and the most accurate scenario has been selected for the implementation of hybrid models. Results of all the models have been examined with a new evaluation index called general index (GI), which is calculated based on the three error statistical indices. Finally, the GEP model outperformed the other models, all the scenarios with GI = 11.268 in the M3 scenario and later, the ELM algorithm presented the best performance with GI = 12.811 in the M2 scenario, while the RF model had the worst overall performance. Regarding the hybrid models, using the EMD and principal components analysis (PCA) methods decreased the precisions of the models with the GI values fluctuating around 35.
Plantas medicinais e fitoterápicos como alternativa terapêutica às infecções urinárias: um diagnóstico dessa realidade na saúde pública de Mossoró
Authors:   , Queiroga Geruzia Marques Teodoro
Published: January 2025

As plantas medicinais são um recurso terapêutico e vêm sendo cada vez mais utilizadas nas sociedades em todo o mundo. Constitui uma ferramenta de preservação do ambiente cultural, de desenvolvimento econômico e social, promovendo melhorias na qualidade de vida da população. O objetivo desse estudo foi avaliar o uso da fitoterapia como alternativa terapêutica no âmbito da saúde pública de Mossoró/RN, considerando o conhecimento popular e científico. O instrumento de coleta de dados quanto a informações sobre a fitoterapia foi um questionário estruturado, aplicado a uma população de 453 sujeitos, dentre os quais, usuários (269) e profissionais de saúde (184) do SUS, arrolados nas Unidades Básicas de Saúde. Para avaliação do uso de espécies vegetais, em enfermidades específicas, fez-se a determinação da atividade antibacteriana dos extratos de plantas citadas em ITU (Phyllanthus niruri L, Punica granatum L e Zea mays L), sobre isolados clínicos de pessoas da comunidade e cepas padrão ATCC de Escherichia coli, Klebsiella pneumoniae e Staphylococcus aureus, utilizando-se o método de Disco Difusão em meio sólido. Os extratos brutos foram testados nas concentrações de 100, 200 e 300 mg/mL tendo como solvente o DMSO. Para a análise dos dados obtidos com os questionários foi utilizado o teste exato de Fisher para tabelas de contingência, já para a comparação do diâmetro dos halos de inibição dos extratos, utilizou-se a análise de variância no delineamento em blocos aleatorizados, e para a comparação das médias dos halos o teste de Student-Newman-Keuls, por meio do software R, com um nível de significância de 5%. Os resultados mostraram que 86,41% dos profissionais da saúde e 89,96% dos usuários dos serviços públicos de saúde conhecem, aceitam e utilizam a fitoterapia como opção terapêutica, e o extrato de Punica granatum como o mais eficaz e com maior espectro de ação quanto às bactérias testadas, confirmando o conhecimento popular quanto à propriedade antibacteriana destas plantas, possibilitando a implantação de uma política pública de saúde municipal, voltada para a fitoterapia como forma de assegurar o direito à saúde da população, sem necessariamente depender da alopatia, tendo o senso comum como instrumento de busca de plantas potencialmente terapêuticas na região.
Synthesis, Characterization, and Reactions of Halogenated Ortho-acetamidostilbenes Mediated by Lewis Acids
Authors: Md. Din Mohd Fadzli , Azmi Mohamad Nurul , Mikhaylov Andrey A. , Sulaiman Syazreen Nadia , Awang Khalijah
Published: January 2025

This study aimed to synthesize a total of seven halogenated amidostilbenes 3a-3f using the Heck
cross-coupling method. The synthesized stilbenes underwent further reactions with Lewis acids, such as FeCl3
and SnCl4, resulting in imines 4 and indolines 5, respectively. The structure of all synthesized compounds was
elucidated using FTIR, 1D- and 2D-NMR, XRD, and HRMS analysis. Furthermore, the mechanistic details
underlying the formation of both imines and indolines were also discussed.
The Quality of Hatching Egg and Development of Embryonic Somites in Kampung and Sentul Chickens
Authors: Zulfikar Muhammad Irsyad , Ulfah Maria , Fahrudin Mokhamad
Published: January 2025

Kampung and Sentul chickens are Indonesian local chicken breeds that are widely developed by breeding companies as strains for meat production. The genetic differences among these chicken strains can impact the quality of the hatching eggs they produce. Somite development is a crucial part of chicken embryo growth during the hatching process, as it precedes the formation of vertebrae and skeletal muscles, ultimately affecting chick quality. This study aimed to analyse how both strains of hens affect hatching egg quality and somite development. The sample included 126 hatching eggs, with 63 from Kampung chickens and 63 from Sentul chickens. The observed parameters of hatching egg quality included egg weight, egg shape index, eggshell thickness, eggshell weight, eggshell strength, albumen index, yolk index, yolk color score, Haugh Unit (HU), and embryo development indicators, such as the development of the primitive streak and progression of somite number. The data were analysed using a t test. Differences between chicken strains significantly affected (P<0.05) egg weight, shell thickness, the albumen index, and HU. The different strains also showed significant differences (P<0.05) in embryo somite development, with the primitive streak development of the Sentul chicken being slower than that of the Kampung chicken. In conclusion, Kampung chickens produce hatching eggs with superior interior quality, primitive streak development and somite number compared to the hatching eggs of other chickens. However, Sentul chickens also demonstrate good exterior egg quality, as shown by their egg weight and shell thickness.
Assessing the Impact of a Virtual Reality Cognitive Intervention on Tennis Performance in Junior Tennis Players: Pilot Study
Authors: Anguera Joaquin A , Choudhry Aleem , Seaman Michael , Fedele Dominick
Published: January 2025

Background

There is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. While the engagement of executive functions is suggested to be part of high-level sporting activities, it is unclear whether such training approaches could directly benefit athletic performance.

Objective

The objective of this study was to evaluate the impact of a combined virtual reality (VR)– and tablet-based cognitive training intervention on adolescent tennis players’ performance. Here, we examined differences in Universal Tennis Rating (UTR) between players who supplemented their regular tennis training with a cognitive training intervention and a group that continued regular tennis training alone. This custom cognitive training program targeted specific cognitive control abilities including attention, working memory, and goal management.

Methods

Data were collected from a cohort of tennis players in a randomized controlled trial design led by the dedicated research team. Participants (N=23, age: mean 14.8, SD 2.4 years) from the Czech Lawn Tenis Klub (Prague, Czech Republic) were invited to participate in this study. These individuals were randomized into an intervention + training-as-usual group (n=13) or training-as-usual group (control group; n=10), with the change in UTR score being the primary metric of interest.

Results

There was no difference in UTR between the 2 groups at baseline (intervention: mean 8.32, SD 2.7; control: mean 7.60, SD 2.3). Following the treatment period, individuals in the intervention group showed a significant improvement in their UTR (an increase of 0.5; t12=4.88, P<.001) unlike the control group (an increase of 0.02; t9=1.77, P=.12). On comparing the change in UTR (posttraining UTR minus pretraining UTR) attained by each group, we found that the intervention group had a 38% greater improvement in UTR than the control group. An analysis of covariance revealed a significantly greater improvement in UTR for the intervention group than for the control group (F1,20=8.82, P=.008).

Conclusions

The present findings suggest that training cognitive abilities through an immersive visual platform may benefit athletic performance, including tennis. Such a result warrants careful consideration, given the known difficulties in evidencing far transfer not only in cognitive studies but also in athletic activities. These preliminary pilot findings suggest that the Mastermind Cognitive Training program may be a viable tool for supplementing athletic training practices, although this result warrants further investigation and replication. However, many questions remain unanswered, and further work is needed to better understand the potential utility and mechanisms underlying potential effects of such a platform.
A Novel Treatment for Scabies with Herbal Formulation: A Clinical Safety Assessment Study
Authors: Shah Arjumand , Habib Arif , Iqbal Arsheed , Rafiq Huma , Ara Irfat , Nighat Dr , Bashrat Dr
Published: January 2025

Introduction: Scabies, known as Jarb in Unani medicine, is a parasitic infection caused by the mite Sarcoptes scabiei var. Hominis. It is characterized by intense itching, particularly noted by patients at night. In India, this disease affects over three million people, manifesting as papular or vesicular eruptions accompanied by pruritus. Unani physicians have developed comprehensive treatments for scabies, considering its causative factors and various types.
Methods: This study was conducted as an open-label, single-arm clinical trial involving 75 patients diagnosed with scabies with male female ration of 1:2.7. The primary objective was to assess the efficacy and safety of a compound Unani formulation. The test group received a Compound Unani formulation Irtifal Shahtra (Fumaria indica Pugsley) at a dose of 5 grams twice daily, Marham Kharish Jadeed (Lawsonia inermis) for topical application twice daily, and Aab-e-Barg-e-Neem (a decoction of Neem leaves) for washing the affected areas before applying Marham twice daily, for a duration of 15 days. Both subjective and objective parameters were evaluated before and after the treatment period.
Results: In this study, 94% patients reported a significant reduction in itching after using unani formulation for Scabies. Only 5% patients had mild itching at the end of the study. Regarding cure of the lesions, the reduction in mean values from before to after treatment indicates an improvement in skin lesions. P-value less than 0.05 indicate that the results are statistically significant. Objective parameters such as the skin scraping test, demonstrated a significant reduction (p<0.001). Importantly, no adverse effects were observed with the treatment regimen, further highlighting its effectiveness in alleviating scabies symptoms.
Conclusion: This study highlights the safe and effective utilization of Unani formulations in treating one of the most distressing skin disease scabies, without any adverse effects.
Keywords: Scabies, Jarb, Itrifal shahtra, Barg neem, Marham Kharish Jadeed, Classical Pharmacopoeial formulations.
In-vitro approaches to evaluate the anti-inflammatory potential of phytochemicals: A Review
Authors: Sabalingam Sriaandhal
Published: January 2025

Phytochemicals, bioactive compounds derived from plants, have drawn considerable attention for their ability to modulate inflammatory pathways, presenting promising alternatives for the treatment of chronic inflammatory diseases. Inflammation, a complex biological response to injury or infection, involves a cascade of cellular and molecular events mediated by enzymes, cytokines, and reactive species. In vitro assays provide an essential platform for screening and investigating the anti-inflammatory potential of phytochemicals, offering valuable insights into their mechanisms of action. Commonly used techniques include the inhibition of protein denaturation and membrane stabilization, which evaluate the ability of compounds to prevent structural damage to proteins and cell membranes. Enzymatic assays, such as cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibition tests, focus on the suppression of key enzymes involved in arachidonic acid metabolism, thereby reducing the production of pro-inflammatory mediators like prostaglandins and leukotrienes. Other assays, like proteinase and hyaluronidase inhibition tests, assess the ability of compounds to block enzymes contributing to tissue degradation and inflammation. These assays offer robust, reproducible frameworks for evaluating phytochemicals in preclinical research, helping to identify compounds with potential therapeutic value. However, their limitations, such as lack of in vivo context and inter-assay variability, necessitate their integration with complementary studies to validate findings and understand their translational significance.
Keywords: Phytochemicals, in vitro methods, anti-inflammatory activity, protein denaturation, membrane stabilization
Epidemiological and clinical profile of rifampicin-sensitive and -resistant pulmonary tuberculosis in sites of displaced persons due to the 2022-2024 floods in N'Djamena, Chad
Authors: Djimenan Boilengar , Togde Gildas le Djimbaye , Nadlaou Bessimbaye , Keloumta Mantangar Clarisse , Rimtebaye Kimassoum
Published: January 2025

Patients with rifampicin-resistant tuberculosis (RR-TB) may remain a source of infection longer than rifampicin-susceptible tuberculosis (RS-TB). The objective of this study was to detect active cases of rifampicin-susceptible and -resistant tuberculosis in displaced persons sites in the 9th District of N’Djamena.
This observational, cross-sectional and analytical study was conducted among 418 contacts of the displaced persons, including 285 in the Walia site and 133 in the Toukra site. Data were collected using a pre-tested, semi-structured questionnaire administered by an interviewer. The identification of active cases of tuberculosis among the displaced persons was carried out by an interview to verify the presence or absence of TB symptoms. The TB-LAMP molecular technique was used to detect active tuberculosis among symptomatic and asymptomatic contacts. Instead, a GeneXpert analysis was carried out to detect cases of tuberculosis sensitive and resistant to rifampicin.
TB-LAMP detected 76 (5.5%) cases of active TB among 418 displaced persons, including 11 lost to follow-up and 65 new cases. Female patients were more dominant (59.21%) than males (40.78%), and the age of patients ranged from 12 to 65 years, with a mean age of 38.5 years with a sex ratio of 1.45 in favor of females. Loss of appetite (31%), asthenia (20.0%) and cough (16%) were the most common symptoms.
GeneXpert confirmed the 76 positive cases of Mycobacterium tuberculosis, of which 8 (10.52%) were resistant and 69 (90.78%) were sensitive to rifampicin.
HIV1/2 immunochromatographic tests detected 12 (15.78%) cases of HIV/tuberculosis coinfection among the positive cases.
This study highlighted the emergence of strains of the Mycobacterium tuberculosis complex resistant and sensitive to rifampicin.
Regular and effective screening of RR-TB contacts is necessary to stop transmission in displaced persons sites in Chad, Africa and even worldwide.
Keywords: Flood, displaced person, Mycobacterium tuberculosis, resistance, rifampicin, molecular technique, Chad.
The Relationship Between Body Mass Index, Waist Circumference, Neck Circumference and Cardiovascular Risk Factors
Authors: AYDIN Mehmet Kasım , BAHÇECI Mitat
Published: January 2025

Background: This study aimed to estimate the correlation between body mass index, waist circumference and neck circumference and cardiovascular risk factors in healthy adult men and women with no history of any disease or chronic drug intake from Diyarbakır and Dicle University medical faculties.
Materials and methods: The study included 199 subjects, 113 males (mean age 36.5 ± 11.3 years) and 86 females (mean age 33.8 ± 11.7 years) aged between 20 and 73 years. Age, height, weight, blood pressure, pulse rate, anthropometric methods; waist circumference (WC), body mass index (BMI), neck circumference (NC), blood glucose and insulin levels were determined. Insulin resistance was evaluated with the Homeostasis model assessment (HOMA-IR) formula. Total-cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol levels were measured. Pearson correlation and independent t-test were applied to the obtained study parameters.
Results: 47.7% of women were obese, 1.2% were morbidly obese and 59.3% of men were obese. Waist circumference correlated with systolic blood pressure (r=0.426, p<0.001), diastolic blood pressure (r=0.414, p<0.001), total cholesterol (r=0.450, p<0.001), triglycerides (r=0.556, p<0.001) and LDL-cholesterol (i=0.486, p<0.001), and a negative correlation was found between waist circumference and HDL-cholesterol (r=0.261, p<0.001). In women, the relationship between BMI and HOMA-IR (r-0.415, p<0.001) was stronger than the relationship between waist circumference and HOMA-IR (r=0.333, p=0.02). In men, we found a positive correlation between waist circumference and HOMA-IR (r=0.271, p=0.04). In men, we found no correlation between BMI and HOMA-IR. Neck circumference was correlated with waist circumference (i=0.732), total cholesterol (r=0.534), triglycerides (r=0.365), LDL cholesterol (i=0.406), BMI (r=0.568), systolic blood pressure (r=0.200), diastolic blood pressure (r=0. 290), and glucose (r=0.280) (p < 0.001).
Conclusions:  Waist circumference was more tightly correlated with metabolic parameters. Waist circumference may better reflect the risk of cardiovascular disease than BMI. Neck circumference measurement, a new obesity indicator, can also be used as an obesity assessment method.
Keywords: Cardiovascular risk factors, body mass index, waist circumference, neck circumference
Design and Characterization of Aceclofenac-Loaded Microballoons using Eudragit with Hydroxypropyl Methylcellulose
Authors: Biswas Souvik , Sengupta Sindhuja , Pegu Padmanath , Dey Nikita , Sen Amartya , Debnath Biplab , Nag Mrinmoy , Amin Nurul , Das Arijit , Datta Soumya , Bishal Amlan
Published: January 2025

Background: Drug delivery systems based on microballoons are one of the promising approaches for gastric retention, especially useful for drugs with site-specific absorption in the stomach. The microballoons are hollow, spherical particles under 200 micrometers, designed to float in the gastric environment. The Aceclofenac formulation of an NSAID is helpful with a half-life of 4–4.3 hours; this delivery form gives a sustained release and maintains constant plasma levels with enhanced bioavailability and decrease in dosing frequency.
Methodology: Microballoons of Aceclofenac were prepared using Eudragit RS 100 and Hydroxy Propyl Methyl Cellulose as polymers from the emulsion–solvent diffusion method. In this, the polymers impart stability along with a profile of controlled release. Here, the microballoons was evaluated for physical parameter and the release profile regarding average particle size, floatation percentage, entrapment efficiency, true tapped density, and percentage yield, and FTIR will be carried out on complexes of drug and polymer.
Results and Discussion: The prepared microballoons exhibit excellent floating properties and uniformity in size, which aided in long gastric retention. High entrapment efficiency with controlled and sustained release of the drug for an extended period was obtained. FTIR studies indicated that Aceclofenac remained stable in the polymer matrix with no considerable chemical interaction between the drug and the polymers.
Conclusion: This research shows promise in microballoons-based delivery systems that could maintain the release for a longer duration from the delivery device with respect to Aceclofenac, which enhances bioavailability and reduces dosing frequencies.
Keywords: Aceclofenac, Microballoons, NSAID, Sustain Release Medication, Eudragit RS100, HPMC
The Life and Art of The Master Singer Park Ki-hong and Characteristics of His Chunhyangga
Authors:   Soc Kor Oral Literature, Choi Hye Jin
Published: January 2025

This study examines the historical status of pansori master Park Ki-hong, examining his life, activities, artistic characteristics, and his view on the education of pansori. It organizes his Chunhyangga, which remains as Okjunghwa, into the context and characteristics of the transmission of Joonggoje (中古制). First, we summarize Park Ki-hong’s life. Park was born in Naju in 1845 and lived there until 1925, gaining fame as a master of Joonggoje. Second, we examine the characteristics of Park’s vocals. To this end, we summarize the characteristics of the vocals and activities of master singers from Park Ki-hong’s teacher Jeong Chun-pung to his disciples Kim Jeong-gil and Jo Hak-jin from the perspective of the history of transmission. Third, we examine Park Ki-hong’s views on vocal education. Park was a strict yet warm educator, and he seemingly taught thorough training and effort. Fourth, we explore the context in which his vocals were transformed into new novels by viewing Okjunghwa as Park Ki-hong’s Joonggoje, Chunhyangga. The fact that Park's Chunhyangga was chosen as a modern performance piece for the improvement of Chunhyangga proves that intellectuals had a strong opinion of Joonggoje. Park's Chunhyangga can be considered to have played a role in announcing a new beginning for modern Chunhyangga. As a work of Park Ki-hong, the characteristics of Okjunghwa include the following: the conflict of love is highlighted, the critical awareness of lyrics that do not fit with customs is revealed, Chunhyang is acknowledged by Lee doryeong's family, there is a scene of Buddhist service at Manbok temple, the reflection of modern lyrics, and the absence of punishment for Byeonsato. In summary, Park Ki-hong must be recognized as a Joonggoje master singer, and Okjunghwa can be said to reflect the reality of Joonggoje Chunhyangga.
Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects
Authors: Hohenstein Anita C. , Gallegos Joylynn , Dang Mylinh , Groegler Jason , Broncucia Hali , Tensun Fatima , Waugh Kathleen , Dong Fran , James Eddie A. , Speake Cate , Steck Andrea K. , Rewers Marian J. , Gottlieb Peter A. , Haskins Kathryn , Delong Thomas , Baker Rocky L.
Published: January 2025

Type 1 Diabetes (T1D) is an autoimmune disease mediated by autoreactive T cells. Our studies indicate that CD4 T cells reactive to Hybrid Insulin Peptides (HIPs) play a critical role in T cell-mediated beta-cell destruction. We have shown that HIPs form in human islets between fragments of the C-peptide and cleavage products of secretory granule proteins. To identify T cell specificities contributing to T1D pathogenesis, we tested T cell reactivity from T1D patients or healthy control using an IFN-γ ELISPOT assay against a library of 240 C-peptide HIPs. We observed elevated T cell responses to peptide pools containing HIPs that form at the amino acid residues G15, A18 and L26 of C-peptide. In a second cohort of healthy controls, at-risk individuals, and T1D patients, T cell reactivity to HIPs forming at these three residues was monitored. Results indicate that, prior to clinical onset of T1D, there were significantly elevated responses to multiple pools of HIPs, and the magnitude of T cell reactivity to HIPs forming at residue A18 of the C-peptide was increased. Overall, our study identifies new T cell specificities in at-risk subjects and indicates that T cell reactivity to HIPs can be observed before T1D onset.
ANÁLISE DO POTENCIAL VERSUS EFETIVA GERAÇÃO DE BIOGÁS NA AGROINDÚSTRIA BRASILEIRA: UM ESTUDO DE 2021
Authors: Oliveira Thais Gomes de , Calil Francine Neves , Sette Junior Carlos Roberto
Published: January 2025

Com o aumento da produção de biogás, resultante da decomposição anaeróbica da matéria orgânica seca por microrganismos, as estimativas do seu uso energético no Brasil têm crescido. Esse crescimento tem motivado cadeias produtivas a reconhecer o potencial dessa fonte energética, levando à concepção de instalações orientadas por requisitos legais, políticas públicas e demandas de mercado, envolvendo diversos atores interessados. Este artigo tem como objetivos: estimar o potencial de geração e a produção efetiva de biogás no Brasil em 2021; destacar o potencial dos resíduos do agronegócio para a geração de energia renovável na forma de biogás; analisar as instalações e a produção de biogás no Brasil durante o ano de 2021; e comparar o potencial de geração com a produção efetiva de biogás em 2021. Como metodologia, trata-se de uma análise documental, comparativa e descritiva. A metodologia adotada é uma análise documental, comparativa e descritiva. Os resultados incluem a produção efetiva de biogás em 2021, juntamente com um ranking relacionado ao potencial de produção de biogás proveniente da agroindústria em diferentes regiões do Brasil.
IMPLEMENTASI SISTEM INFORMASI MANAJEMEN KLINIK MENGGUNAKAN METODE BLACK BOX TESTING
Authors: MARDIATI DINA , SAPUTRA YANTO
Published: January 2025

Sistem Informasi Manajemen Klinik (SIM Klinik) merupakan perangkat lunak yang dirancang untuk mengelola data dan proses operasional di lingkungan klinik secara efektif dan efisien. Penelitian ini bertujuan untuk mengimplementasikan dan menguji SIM Klinik dengan menggunakan metode Black Box Testing. Metode ini dipilih karena mampu menguji fungsionalitas perangkat lunak berdasarkan kebutuhan pengguna tanpa memeriksa kode sumbernya. Pengujian difokuskan pada validasi input, proses, dan output dari fitur-fitur utama, seperti pendaftaran pasien, pencatatan riwayat terapi, penjadwalan janji temu, dan pengelolaan inventaris obat. Hasil pengujian menunjukkan bahwa sistem yang dikembangkan telah memenuhi spesifikasi kebutuhan dan berfungsi dengan baik sesuai dengan yang diharapkan. Dengan implementasi ini, SIM Klinik diharapkan dapat meningkatkan efisiensi operasional, meminimalkan kesalahan data, dan mempercepat proses pelayanan di klinik. Penelitian ini juga memberikan kontribusi dalam mengevaluasi kendala sistem informasi berbasis teknologi dalam sektor kesehatan.
PENERAPAN METODE NEWTON GREGORY DALAM MERAMALKAN GARIS KEMISKINAN DI SUMATERA SELATAN
Authors: Damayanti Nadia , Aprianoputri Aurahaqqi , Desfourtheen Rinda , Oktalia Marheska , Saputra Dimas Riski , Puspasari Shinta
Published: January 2025

Kemiskinan masih menjadi masalah kompleks di berbagai daerah termasuk Sumatera Selatan. Garis kemiskinan diprediksi menggunakan metode interpolasi Newton-Gregory berdasarkan data historis dari Badan Pusat Statistik (BPS) dari tahun 2022–2024. Metode ini dipilih karena mudah digunakan dan mampu memberikan data yang akurat. Penelitian ini menggunakan bahasa pemrograman Python, yang membantu pengolahan data menjadi lebih efisien. Hasil penelitian menunjukkan bahwa metode ini memberikan prediksi yang sangat akurat dengan nilai Mean Absolute Percentage Error (MAPE) sebesar 2,81%. Berdasarkan hasil prediksi menunjukkan bahwa garis kemiskinan di sebagian besar wilayah akan meningkat pada tahun 2024 dan 2025. Ogan Komering Ulu Selatan memiliki garis kemiskinan terendah, sedangkan Kota Palembang memiliki garis kemiskinan tertinggi. Diharapkan penelitian ini bisa menjadi alternatif untuk membantu perencanaan pembangunan berbasis data yang lebih baik.Keywords: Proverty, Newton-Gregory Interpolation, South Sumatera, Prediction, MAPE
RANCANG BANGUN APLIKASI PENJUALAN BERBASIS WEB (TOKO AKBAR)
Authors: Duson Irwahya , Sulaeman Budiawan , Suppa Rinto
Published: January 2025

Abstark. Perkembangan teknologi informasi yang pesat mendorong banyak bisnis untuk beralih ke platform digital guna meningkatkan efisiensi dan jangkauan pasar. Toko Akbar, sebuah usaha dagang, membutuhkan sistem penjualan berbasis web untuk mempermudah pengelolaan data produk, transaksi, dan pelaporan penjualan. Penelitian ini bertujuan untuk merancang dan membangun aplikasi penjualan berbasis web yang dapat mengotomatisasi proses bisnis di Toko Akbar, meningkatkan pengalaman pelanggan, dan mengoptimalkan pengelolaan usaha. Metodologi yang digunakan dalam pengembangan aplikasi ini adalah metode Waterfall, yang meliputi tahapan analisis kebutuhan, perancangan, implementasi, pengujian, dan pemeliharaan. Teknologi yang digunakan mencakup framework CodeIgniter sebagai platform pengembangan, MySQL sebagai basis data, dan HTML/CSS untuk antarmuka pengguna. Aplikasi ini dilengkapi dengan fitur-fitur utama seperti manajemen produk, keranjang belanja, sistem pemesanan, pembayaran, dan laporan penjualan.Hasil pengujian menunjukkan bahwa aplikasi mampu memenuhi kebutuhan fungsional dan non-fungsional yang telah ditetapkan. Dengan adanya aplikasi penjualan berbasis web ini, Toko Akbar dapat meningkatkan efisiensi operasional, mengurangi kesalahan dalam pengelolaan data, serta memperluas akses pelanggan terhadap produk yang ditawarkan.Abstract. The rapid development of information technology has encouraged many businesses to transition to digital platforms to improve efficiency and expand market reach. Toko Akbar, a trading business, requires a web-based sales system to facilitate the management of product data, transactions, and sales reporting. This study aims to design and develop a web-based sales application to automate business processes at Toko Akbar, enhance customer experience, and optimize business management. The methodology used in the development of this application is the Waterfall method, which includes the stages of requirements analysis, design, implementation, testing, and maintenance. The technologies utilized include the CodeIgniter framework as the development platform, MySQL as the database, and HTML/CSS for the user interface. This application features key functionalities such as product management, shopping cart, ordering system, payment, and sales reporting. Testing results show that the application meets the defined functional and non-functional requirements. With this web-based sales application, Toko Akbar can improve operational efficiency, reduce errors in data management, and expand customer access to its products.
PROTOTYPE SISTEM KONTROL RUMAH PINTAR MENGGUNAKAN KAMERA BERBASIS INTERNET OF THINGS (IoT)
Authors: Ferella Ferella , Paembonan Solmin , Abduh Hisma
Published: January 2025

Abstark. Kemajuan teknologi Internet of Things (IoT) telah membuka peluang besar dalam pengembangan sistem rumah pintar yang lebih cerdas dan efisien. Penelitian ini bertujuan untuk merancang dan membangun sebuah prototipe sistem kontrol rumah pintar menggunakan kamera berbasis IoT. Sistem ini mengintegrasikan perangkat keras, seperti modul kamera dan mikrokontroler, dengan aplikasi berbasis web atau seluler untuk memantau dan mengontrol perangkat rumah secara real-time. Fitur utama dari sistem ini meliputi pemantauan visual melalui kamera, deteksi gerakan, dan notifikasi otomatis ke pengguna jika terdeteksi aktivitas mencurigakan. Sistem juga memungkinkan pengguna untuk mengontrol perangkat rumah seperti lampu, kipas angin, atau pintu melalui koneksi internet, baik secara manual maupun otomatis berdasarkan data dari kamera. Teknologi yang digunakan mencakup protokol komunikasi IoT (seperti MQTT atau HTTP) dan pemrosesan gambar untuk meningkatkan keamanan dan kenyamanan. Hasil pengujian menunjukkan bahwa sistem prototipe mampu memberikan respons cepat terhadap input pengguna dan deteksi kamera, serta memastikan keamanan data melalui enkripsi. Dengan demikian, prototipe ini dapat menjadi langkah awal dalam mengembangkan solusi rumah pintar yang lebih cerdas, aman, dan mudah diakses bagi masyarakat luas.Abstract. The advancement of Internet of Things (IoT) technology has opened significant opportunities in developing smarter and more efficient smart home systems. This research aims to design and develop a prototype of a smart home control system using a camera based on IoT. The system integrates hardware, such as camera modules and microcontrollers, with web- or mobile-based applications to monitor and control home devices in real time. The main features of this system include visual monitoring through cameras, motion detection, and automatic notifications to users when suspicious activities are detected. The system also enables users to control home devices, such as lights, fans, or doors, via internet connections, either manually or automatically based on data from the camera. The technologies utilized include IoT communication protocols (such as MQTT or HTTP) and image processing to enhance security and convenience. Testing results demonstrate that the prototype system can respond quickly to user inputs and camera detection while ensuring data security through encryption. Therefore, this prototype serves as an initial step in developing smarter, safer, and more accessible smart home solutions for the broader community.
PERANCANGAN SISTEM MONITORING KETAHANAN JEMBATAN BERBASIS IOT (INTERNET OF THINGS)
Authors: Satria Syach Dewa Dinasti , Astutik Rini Puji
Published: January 2025

Jembatan ialah merupakan bagian penting dari infrastruktur jalan sering kali digunakan untuk layanan lalu lintas, menyatukan ruas jalan yang terputus oleh rintangan seperti sungai, lembah, dan saluran lainnya. Namun, seiring waktu, jembatan dapat mengalami kerusakan struktural akibat faktor lingkungan, beban berlebih, getaran, dan usia. Kerusakan ini sering kali tidak terlihat dan dapat mengakibatkan bencana jika tidak terdeteksi dan ditangani.Salah satu penyebab utama adalah beban berlebih yang melewati jembatan. Oleh karena itu, diperlukan pemeliharaan dan monitoring jembatan yang efektif untuk meminimalisir terjadinya keruntuhan. Pemantauan kondisi jembatan secara manual memiliki keterbatasan karena bersifat periodik dan tidak mampu mendeteksi perubahan atau kerusakan secara tiba-tiba, selain memerlukan biaya dan waktu yang besar. Teknologi Internet of Things (IoT) menawarkan solusi dengan memungkinkan perangkat untuk memperbarui diri sesuai perubahan lingkungan dan bekerja dengan akurasi tinggi. Dalam penelitian ini, penulis mengusulkan sistem monitoring ketahanan jembatan berbasis IoT. Sistem ini dirancang untuk mendeteksi parameter lingkungan yang berkaitan dengan ketahanan jembatan, seperti getaran, suhu, kelembaban, dan perubahan struktur. Dengan menggunakan mikrokontroler sebagai pusat data, sistem ini telah memberikan update secara real-time dan dapat diakses setiap saat, sehingga mendeteksi kerusakan dan ketahanan jembatan lebih awal.
RANCANGAN MONITORING BATTERY CHARGING PERALATAN GLIDE PATH SELEX SI-2100 MENGGUNAKAN NODEMCU BERBASIS APLIKASI ANDROID
Authors: Naufal Achmad
Published: January 2025

Glide Path bekerja pada frekuensi Ultra High Frekuensi (UHF) antara 309,15Mhz hingga 335,4Mhz dan berfungsi memberikan informasi panduan sudut luncur 3ᵒ saat melakukan prosedur pendaratan agar pesawat mendarat tepat pada touchdown. Pada Perusahaan umum (Perum) Lembaga Penyelenggara Pelayanan Navigasi Penerbangan Indonesia (LPPNPI) Cabang Palembang dalam pelaksanaan perawatan peralatan navigasi diwajibkan mengisi LogBook harian terutama pada peralatan Glide Path merek Selex tipe SI-2100. Sesuai Peraturan Direktur Jendral Perhubungan KP 35 Pasal 12 Tahun 2019 ayat 2 dijelaskan bahwa pada poin b pemeriksaan status indikator dan pembacaan parameter termasuk kedalam pemeliharaan tingkat 1 fasilitas navigasi penerbangan. Oleh karena itu, penulis memiliki ide untuk membuat sebuah rancangan monitoring Battery Charging pada peralatan Glide Path yang dapat memonitoring tegangan pada baterai 1 dan baterai 2 dengan menampilkan informasi suhu, tegangan, arus dan daya secara aman dan mudah. Diharapkan rancangan ini dapat digunakan sebagai monitoring tegangan Battery Charging pada peralatan Glide Path merk Selex agar memudahkan teknisi untuk melakukan perawatan dan memonitoring baterai back up peralatan navigasi Glide Path Selex SI-2100 yang sebelumnya hanya menggunakan avo meter sebagai media alat ukur.
ANALISIS PERBANDINGAN ANGKA PUTUS SEKOLAH DASAR NEGERI DAN SWASTA MENGGUNAKAN ALGORITMA K-NEAREST NEIGHBORS (K-NN)
Authors: Silalahi Yayi Naulia , Panjaitan Rosita , Harahap Lailan Sofinah
Published: January 2025

Artikel ini mengulas perbandingan tingkat putus sekolah antara sekolah dasar negeri dan swasta di Indonesia, dengan memanfaatkan algoritma K-Nearest Neighbors (KNN) untuk menganalisis data. Studi ini bertujuan untuk menemukan provinsi yang memiliki tingkat putus sekolah tertinggi serta menganalisis pola-pola yang membedakan status pendidikan berdasarkan informasi yang ada. Data menunjukkan bahwa tingkat putus sekolah lebih tinggi di sekolah negeri daripada di sekolah swasta. Algoritma KNN telah berhasil digunakan dalam klasifikasi dan menghasilkan evaluasi yang memuaskan, yang menunjukkan kemampuannya sebagai alat bantu dalam pengambilan keputusan di bidang pendidikan. Artikel ini ditutup dengan saran kebijakan untuk mengurangi tingkat putus sekolah, khususnya pada sekolah negeri.
REKOMENDASI DRAMA KOREA MENGGUNAKAN CONTENT-BASED FILTERING DENGAN WEIGHTED TREE SIMILARITY
Authors: Yuricha Yuricha , Phan Irwan Kurnia
Published: January 2025

Setiap tahun, ratusan drama Korea dirilis, menghadirkan tantangan bagi penonton untuk memilih tontonan yang sesuai dengan preferensi mereka. Fenomena Paradox of Choice menggambarkan bagaimana manusia cenderung bingung saat dihadapkan dengan banyak pilihan dan salah satu cara mengatasinya adalah dengan sistem rekomendasi yang dapat membantu pengguna dalam mempercepat pengambilan keputusan dan mencapai kenyamanan pengguna. Penelitian ini bertujuan membangun sistem rekomendasi drama Korea menggunakan metode Content Based Filtering (CBF) dengan algoritma Weighted Tree Similarity untuk membantu penonton memilih drama berdasarkan kesamaan konten. Model dikembangkan dengan pembobotan fitur, di mana screenwriter memiliki bobot tertinggi (6), diikuti synopsis (2), actor (1), dan director (1). Evaluasi model dilakukan menggunakan ground truth dari rekomendasi MyDramaList dengan metrik precision, recall, dan F1-score. Hasil evaluasi menunjukkan nilai precision 0,80 dan recall 0,75, dengan F1-score sebesar 0,774.