bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Female Directors on Product Recall Decisions
Authors: Wowak Kaitlin D. , Ball George P. , Post Corinne , Ketchen David J.
Published: March 2020

Problem definition: The influence of female directors on firm decision-making and performance is a frequently studied research topic but has received limited attention in operations management. We investigate if adding female directors to a firm’s board of directors changes whether and how quickly the firm recalls defective products. Academic/practical relevance: By demonstrating a relationship between an increase in female directors and more rule-conscious, customer-focused recall decisions, we highlight that adding female directors may enable more societally beneficial operational decisions. Methodology: We analyze 4,271 medical product recalls from 2002 to 2013 across 92 publicly traded firms regulated by the Food and Drug Administration using negative binomial and ordinary least squares fixed effect regression models. In robustness checks, we include an instrumental variable analysis, propensity score matching models, and reverse causality regression models. Results: As boards add female directors, recall decisions change. Firms initiate more medical product recalls that are low in severity and hence easier for firms to avoid initiating, highlighting the increased rule-following brought to bear by adding female directors. Firms also make faster recall decisions for the most serious defects that are high in severity and dangerous for customers, highlighting the increased stakeholder responsiveness resulting from adding female directors. Managerial implications: Firms may more closely align recall decisions with regulatory rules and become more sensitized to customer health and safety by adding female directors. Further, at least two female directors may be required to speed up recall decisions for the most serious, life-threatening defects.
A Odisseia de Penélope
Authors: Castro Elis Crokidakis , De Oliveira Sandra Verônica Vasque Carvalho
Published: March 2020

RESUMO: Na pós-modernidade, a Odisseia é de Penélope e não de Ulisses. Revisitando o clássico de Homero, através da escritora Margaret Atwood, daremos voz à personagem que, se era antes secundária, agora é a principal do enredo. O objetivo desse trabalho é, assim, apresentar tal assertiva e as relações existentes entre os textos, mostrando como a antiguidade dialoga com os tempos atuais. Palavras-Chave: Odisseia, Penélope, Pós-modernidade.
AFINAL, O QUE É TRAGÉDIA?
Authors: Da Rocha Alexandra Marla Marques
Published: March 2020

Percebe-se que o tempo dá conta de fazer mudanças não só em nós, seres de linguagem, mas também, e por extensão, no sentido das palavras. Tragédia, por exemplo, palavra que vem do grego traigoidia, pelo latim tragoedia, adquiriu grafias distintas como já se observa, mas também sentido diverso ao longo do tempo. Antes, porém, da referida análise, seria o caso de verificar o conceito de tragédia que tem início com os tragediógrafos gregos e assume variações de sentido até a contemporaneidade. Para observar tal alteração, faz-se necessário revisitar o passado, especificamente, a antiga Grécia, uma vez que lá foi o berço desse gênero literário. É certo que, mais afastado ou semelhante em seu sentido ao que os gregos atribuíam ao termo, a palavra “tragédia” perdura ainda hoje em temas de romances, dramas, contos, poesias. Utilizado em notícias para qualificar acidentes e catástrofes, o termo também compõe o vocabulário da vida doméstica, atribuído a desafortunados e às vezes simples acontecimentos do dia a dia. O terror e a piedade que sentimos, hoje, diante de acontecimentos inesperados, a que chamamos de tragédias, evidencia, que os homens mantêm em sua história, desde o princípio de sua existência, sentimentos que afloram de modo similar. Para discorrer sobre a origem da tragédia grega, consultamos os autores: Jacqueline de Romilly (1997), Albin Lesky (1990) e o indispensável estagirita Aristóteles. Quanto à tragédia moderna nos pautaremos nas reflexões de Williams (2002), Machado (2006) e Serra (2006).
Uma imagem do homoerotismo em Contra Timarco
Authors: Coutinho Marcelo
Published: March 2020

O presente artigo tem como objetivo abordar o tema da moral sexual na sociedade ateniense do século IV a.C. com base na obra de Ésquines Contra Timarco, um discurso jurídico que visa a impedir um político em ascensão de testemunhar em um processo contra si no futuro, sob a acusação de, entre outros desvios morais, ter se prostituído no início da vida adulta. Para tal, serão utilizadas as considerações de Michel Foucault, que em História da Sexualidade: o uso dos prazeres traçou bases para a investigação do código moral que deveria orientar o comportamento sexual dos gregos, e também os apontamentos de Kenneth Dover, que em Greek Homosexuality apresenta como os gregos lidavam com relações homoeróticas e de que forma representavam as mesmas na poesia, no teatro e nas artes. Cumpre informar que todas as datas no texto em questão, a menos que haja indicação contrária, são da era pré-cristã.
Jesus, o Herói Trágico: Estudo comparativo entre o herói da tragédia e o protagonista do romance A Última Tentação de Cristo
Authors: Oliveira Heitor Victor Narciso de
Published: March 2020

O teatro trágico dos gregos não pode mais retornar, isso é um fato, mas é marcante a sua presença ainda em nossa literatura ocidental. Analisar o elemento trágico não é necessariamente uma novidade, mas sem dúvidas uma tarefa menos comum é atualizarmos a relação entre o trágico e mítico na literatura moderna. O presente trabalho pretende, pois, indicar como o mito cristão pode ser atualizado por meio do elemento trágico, não mais pelo texto dramático, mas por meio do romance. Analisarei o herói trágico como elo entre a tragédia grega e o romance A Última Tentação de Cristo, de Níkos Kazantzákis, estabelecendo um paralelo entre a função do teatro grego e o possível impacto do romance sobre uma sociedade que reconheça a Paixão como um mito.
Fluorescence modulation of the nitrogen-vacancy center with competition between charge-state conversion and stimulated emission
Authors: Du Bo , Chen Xiang-Dong , Zhang Shao-Chun , Dong Yang , Li Cui-Hong , Guo Guang-Can , Sun Fang-Wen
Published: March 2020

The nitrogen-vacancy (NV) center in diamond has been widely used for quantum information processing, nanophotonics, and biological imaging. In this work, we experimentally studied the charge-state conversion and stimulated emission of the NV center with a near-infrared (NIR) pumping laser. The competition between these two processes resulted in a nonmonotonic dependence of the NV center’s fluorescence intensity on the NIR laser power. Fluorescence enhancement was observed with a weak NIR laser, while fluorescence depletion was observed with a high-power NIR laser. It led to the nonmonotonic change of the spatial resolution with stimulated emission depletion microscopy, which has been used for subdiffraction imaging of the NV center. Our work can help to further understand the optical mechanism and extend the applications of the NV center.
Demonstration of multi-channel fiber optic interrogator based on time-division locking technique in subway intrusion detection
Authors: Huang Wenzhu , Zhang Wentao , Huang Jiantao , Li Fang
Published: March 2020

Low noise, good consistency, and long-term stability are critical for a multi-channel fiber optic intrusion detection system. This paper proposes a low-noise 32-channel fiber optic interrogator based on phase generation carrier technique, which emphasizes on the analysis of key parameters related to system consistency and stability. A novel time-division locking technique of the carrier modulation depth and carrier phase delay is proposed. By locking the carrier modulation depth and carrier phase delay simultaneously, the consistency and stability of the multi-channel interferometric interrogator is significantly improved. The results show that in the multi-channel system, the noise level of each channel is below 12.6 ng/√Hz @ 5 Hz, and the noise level differences between each two channels are less than 2.6 dB, the noise level fluctuations of all channels are less than 1.4 dB over 24 hours. A subway intrusion detection is demonstrated in Shenzhen, China. Geological drilling events can be clearly recorded and identified.
CARBOHYDRATE COUSINIA ANGRENI JUS (ASTERACEAE), ESTABLISHING THE STRUCTURE OF THEIR GLU-COFRUCTANS
Authors: Turdumambetov Kenesh Turdumambetovich , Azhibaeva Zulayka Sulaimanovna , Jorupbekova Dzhanymbyu , Goncharova Raisa Andreyevna , Ernazarova Elnura Esenbaevna
Published: March 2020

Currently, a lot of attention is paid to a number of researchers oligo – and polysaccharides. This is due to their high content in plant materials and the fulfillment of a special role in the development of living organisms, which is of great importance in the production of fructose, sucrose and inulin.

Kyrgyzstan has huge reserves of still little-studied, environmentally friendly medicinal and other plant species.

The article deals with the study of the chemical composition of the carbohydrate complex in plants of the genus Cousinia angreni Jus. Experimental studies have been carried out to isolate and establish structures of water-soluble polysaccharides and alcohol-soluble oligosaccharides. Glucofructan was isolated from the roots of Cousinia angreni Jus, the structure of individual fractions was studied by methylation, periodic oxidation, paper chromatography, thin-layer chromatography and GLC, IR and 13C-NMR spectroscopy.

When compared with witnesses, 2,3,4,6-tetra-O-Me-D-glucose, 1,3,4,6-tetra-O-Me-D-fructose, 3,4,6-tri-O-Me-D-fructose (main product) and trace amounts of 1,3,4-tri-O-Me-D-fructose. The presence of the main product 3,4,6-tri-O-Me-D-fructose indicates the predominance of β-(2→1) bonds. Thus, it was found that glucofructans of the Angren cousin (C. angreni Jus) consist of fructofuranose residues linked by β-(2→1) inulin type bonds.
STANDARDIZATION OF DRY EXTRACT OF ZIZIPHUS JUJUBA MILL. FRUITS
Authors: Presniakova Viktoriya Sergeyevna , Farmanova Nadira Tahirovna , Turdieva Zilola Vohobjanovna
Published: March 2020

Ziziphus jujuba Mill. (jujube) fruits have been used in folk medicine for a long time as a drug to treat arterial hypertension. Scientists in A. Sultanov Uzbek Research Institute for Chemistry and Pharmaceutics have developed a technology that permits to obtain dry extract named «Unabin» with hypotensive effect.

The aim of research: to develop quality control and standardization methods for dry extract of jujube fruits.

Jujube dry extract was described as a brown powder with sweet taste and specific odor. Water content in samples was 3.1–4.8% (measured according to State Pharmacopoeia of Russian Federation XI).

We studied 5 series of dry extract. It was revealed that 1 g of dry extract contains 106 of aerobic bacteria, 103 of yeasts and mold fungi altogether, 102 of enterobacteria and other gram-negative bacteria in average. Esherichia coli, Salmonella, Pseudomоnаs aeruginosa и Staphylococcus aureus were not detected. Therefore, the studied pharmaceutical meets the standard of microbiological cleanliness.

The optimal content of the following substances was determined: flavonoids (in rutin equivalent; no less than 0.2%), polysaccharides (no less than 1.8%), organic acids (in malic acid equivalent; no less than 1.5%), tanning agents (in tannin equivalent; no less than 5.0%). The proposed permissible content of heavy metals (Pb, Cd) is 0.01% or less.

The shelf life of jujube dry extract is 2 years and more (assessed in natural conditions according to Branch Standard 42-2-70). The project of Pharmacopoeia article was prepared on the basis of conducted reseach.
THE CHANGES OF CHEMICAL PARAMETERS OF PEAT-FORMING PLANTS DURING DECOMPOSITION PRO-CESSES ON KARST-SUFFUSION MIRES OF THE MIDDLE-RUSSIAN UPLAND
Authors: Volkova Elena Mikhaylovna , Boykova Ol'ga Ivanovna , Khlytin Nikolay Viktorovich
Published: March 2020

The variety of biosphere functions of mire ecosystems is associated with the intensity of vertical growth of peat deposits, which is correlated with the rate of decomposition of plant remains. This process depends on the complex of ecological conditions and accompanies by changes in the chemical composition of plants. For studying of dynamics of the chemical parameters of the main peat-forming plants on the model karst-suffusion mire, an experiment was conducted with the laying of plant material in the peat. Plant samples were placed in peat to a depth of 5–7 cm in different parts of the mire, which is corresponded to the original place of species growing. After 1 and 2 years, the samples were removed from the peat and elemental analysis was carried out on the CHN-analyzer Carlo Erba 1100, ash content was determined by weight method and the degree of decomposition of plant remains was done by microscopy method. The results shows, that during the 2-year experiment the degree of decomposition of plants remains was changed by different ways. The herbs are least resistant for decomposition in the peat, but sphagnum mosses are the most resistant. The process of decomposition of plant remains is accompanied by a decreasing of ash content in vascular plants and increasing in sphagnum mosses, which is associated with their ability to accumulate surface runoff substances and atmospheric dust. During the transformation of plant material the content of carbon and nitrogen are changing. The C/N ratio indicates an uneven proportion of carbon and nitrogen at different stages of decomposition in different plant species, which correlates with the degree of decomposition.
STRAWBERRY FRUIT (FRAGARIA × ANANASSA DUCH.) AS A VALUABLE SOURCE OF NUTRITIONAL AND BIO-LOGICALLY ACTIVE SUBSTANCES (REVIEW)
Authors: Akimov Mikhail Yur'yevich , Luk’yanchuk Irina Vasil'yevna , Zhbanova Ekaterina Viktorovna , Lyzhin Aleksandr Sergeyevich
Published: March 2020

For the last time a lot of attention has been paid to strawberry as a garden crop. All this thanks to its preventive and medical benefits related to the consumption of its fruit. The paper presents the data analysis of foreign and domestic researchers on the accumulation of basic food components (sugars, organic acids), vitamins, mineral substances and other valuable ones in. Which determine the high antioxidant properties of strawberries. On the basis of scientific literature sources, the vitamin profile was compiled wich reflects the accumulation of vitamin groups, specific for a given crop. With all diversity of vitamins found in strawberry fruits, the fruits of this plant are primarily good as a valuable source of ascorbic acid, folic acid, polyphenolic compounds (anthocyanins, ellagic acid). As for mineral substances, the presence of iron amount confirms the fact. In spite of fact that the strawberry composition is studied enough, the further detailed characterization of genetic resources is necessary both by total antioxidant activity and by definite chemical components, the last ones, obviously, present the antioxidant complex of strawberry fruits. The given information will be a base for future related investigations of phytochemical compounds of fruits and berries. They are extraordinary important in healthy food of humans as well as in creation of nutraceutical products.
STRUCTURE OF POLYPHENOLS OF LEAVES TANNING SUMAC RHUS CORIARIA L.
Authors: Ziyavitdinov Zhamollitdin Fazlitdinovich , Oshchepkova Yuliya Igorevna , Abdulladzhanova Nodira Gulyamzhanovna , Salikhov Shavkat Ismailovich
Published: March 2020

The aim of this work is to study the composition and structural characteristics of the polyphenols of the tanning sumac Rhus coriaria L. of the Anacardiaceae family, growing in Uzbekistan, using a high-performance liquid chromatograph with a diode-matrix detector (HPLC-DAD) and a tandem temple mass-spectrometer (HPLC– Q-TOF-MS / MS).

The phenolic compounds of the aerial part (leaves) of Rhus coriaria L. plants of the Anacardiaceae family were studied. For the first time, polyphenol fractions were isolated from tanning sumac leaves using stepwise hydrophobic chromatography. By HPLC, as a result of semi-preparative chromatography from the fraction eluted with 30% ethanol, 9 individual compounds were obtained, in the amount of: R-1 – 0.5 mg, R-2 – 0.8 mg, R-3 – 2.3 mg, R-4 – 12.6 mg, R-5 – 34.5 mg, R-6 – 15 mg, R-7 – 8 mg, R-8 – 7.1 mg, R-9 – 45.5 mg As a result of mass spectrometric analyzes and NMR spectroscopy for individual polyphenols, it was established that the polyphenols isolated in the individual state consist of gallic acid and glucose, interconnected by an ester bond: mono-, di-, tri-, tetra-, penta- , hexa-, hepta-, octa- and non-O-galloyl-β-D-glucose.
Predictors of Adherence to Anti-Hypertensive Therapy: Systematic Review and Meta-Analysis
Authors: Silva Neto Raimundo Monteiro da , Silva Cícero Rafael Lopes da , Arrais Teresa Maria Siqueira Nascimento , Tavares Sâmia Macedo Queiroz Mota Castellão , Moura Maria Elisa Regina Benjamim de , Saraiva Emanuela Machado Silva , Veras Helenicy Nogueira Holanda , Santana Milana Drumond Ramos , Carvalho Poliana Moreira de Medeiros
Published: March 2020

Low adherence to antihypertensive therapy is one of the main modifiable risk factors for several other secondary pathologies. Therefore, we aimed to evaluate the predictors that most interfere in the adherence process. This is a systematic review with meta-analysis that followed the Cochrane recommendations, the search for studies occurred between January and February 2020 using the MeSH: "Hypertensive", "Medication Adherence", "World Population" and "Risk Factors". After applying the filters and criteria 31 studies were selected. The review included studies with intended perspectives and the main predictors were: interventions, satisfaction, cost reduction, the factors were also found: diagnostic impact, medical inertia and execution of the prescribed regimes. The research exposed that more work is needed on health promotion by age group and hypertension (SAH) can be detected and controlled early, readjust high costs, ensure well-being and satisfaction in therapy so that the patient can feel comfortable. Personalized recommendations and constructive comments can drive this process, it is necessary to develop actions aimed at greater compliance by reducing the impact of these diseases and promoting greater control Compliance has always been complex by nature. However, relatively small interventions can substantially improve it. Keywords: Hypertensive; Medication Adherence; World Population; e Risk Factors.
Fertilizer doses for jute cultivation after onion harvest
Authors: Rani Debnath Manika , Mahabubul Islam Md. , Ayub Khan Md. , Akter Sharmin , Mukul Mia1, Protap Narayan Nandi Md.
Published: March 2020

An experiment was conducted to evaluate the fertilizer dose for jute cultivation at the field after harvesting of onion at Gangabordi and Talma, Faridpur during 2017 with five treatments with different level of Urea, Triple Super Phosphate, Muriate of Potash and Gypsum. The result revealed that the treatment of higher doses of fertilizer gave the statistically significant highest fibre (2.76t/ha) yield whereas treatment of lower doses of fertilizer gave the lowest fibre yield (2.40 t/ha) but the Benefit Cost ratio from different treatment showed statistical non significance. From the view of economic profitability, farmers may use no fertilizer at their field during jute cultivation where previous crop was onion.
Demand-aware route planning for shared mobility services
Authors: Wang Jiachuan , Cheng Peng , Zheng Libin , Feng Chao , Chen Lei , Lin Xuemin , Wang Zheng
Published: March 2020

The dramatic development of shared mobility in food delivery, ridesharing, and crowdsourced parcel delivery has drawn great concerns. Specifically, shared mobility refers to transferring or delivering more than one passenger/package together when their traveling routes have common sub-routes or can be shared. A core problem for shared mobility is to plan a route for each driver to fulfill the requests arriving dynamically with given objectives. Previous studies greedily and incrementally insert each newly coming request to the most suitable worker with a minimum travel cost increase, which only considers the current situation and thus not optimal. In this paper, we propose a demand-aware route planning (DARP) for shared mobility services. Based on prediction, DARP tends to make optimal route planning with more information about requests in the future. We prove that the DARP problem is NP-hard, and further show that there is no polynomial-time deterministic algorithm with a constant competitive ratio for the DARP problem unless P=NP. Hence, we devise an approximation algorithm to realize the insertion operation for our goal. With the insertion algorithm, we devise a prediction based solution for the DARP problem. Extensive experiment results on real datasets validate the effectiveness and efficiency of our technique.
DeepDB
Authors: Hilprecht Benjamin , Schmidt Andreas , Kulessa Moritz , Molina Alejandro , Kersting Kristian , Binnig Carsten
Published: March 2020

The typical approach for learned DBMS components is to capture the behavior by running a representative set of queries and use the observations to train a machine learning model. This workload-driven approach, however, has two major downsides. First, collecting the training data can be very expensive, since all queries need to be executed on potentially large databases. Second, training data has to be recollected when the workload or the database changes. To overcome these limitations, we take a different route and propose a new data-driven approach for learned DBMS components which directly supports changes of the workload and data without the need of retraining. Indeed, one may now expect that this comes at a price of lower accuracy since workload-driven approaches can make use of more information. However, this is not the case. The results of our empirical evaluation demonstrate that our data-driven approach not only provides better accuracy than state-ofthe- art learned components but also generalizes better to unseen queries.
Enabling low tail latency on multicore key-value stores
Authors: Lersch Lucas , Schreter Ivan , Oukid Ismail , Lehner Wolfgang
Published: March 2020

Modern applications employ key-value stores (KVS) in at least some point of their software stack, often as a caching system or a storage manager. Many of these applications also require a high degree of responsiveness and performance predictability. However, most KVS have similar design decisions which focus on improving throughput metrics, at times by sacrificing latency. While latency can be occasionally reduced by over provisioning hardware, this entails significant increase in costs. In this paper we present RStore, a KVS which focus on low tail latency as its primary goal, while also enabling efficient usage of hardware resources. To that aim, we argue in favor of techniques such as an asynchronous programming model, message-passing communication, and log-structured storage on modern hardware. Throughout the paper we discuss these and other design decisions of RStore that differ from those of more traditional systems. Our evaluation shows that RStore scales its throughput with an increasing number of cores while maintaining a robust behavior with low and predictable latency.
Russell’s Use Theory of Meaning
Authors: Griffin Nicholas
Published: March 2020

Russell is often accused of having a naive ‘Fido’–Fido theory of meaning of the sort Wittgenstein attacked at the beginning of the Philosophical Investigations. In this paper I argue that he never held such a theory though I concede that, prior to 1918, he said various things that might lead a very careless reader to suppose that he had. However, in The Analysis of Mind (1921), a book which (from the work of Garth Hallett) we know Wittgenstein studied closely, Russell put forward an account of understanding an utterance which clearly anticipates the use theory of meaning usually attributed to Wittgenstein. The paper concludes with some problems for understanding the use theory of meaning as presented by both Russell and, derivatively, Wittgenstein.
The role of 68Ga-DOTA derivatives PET-CT in patients with ectopic ACTH syndrome
Authors: Ceccato Filippo , Cecchin Diego , Gregianin Michele , Ricci Giacomo , Campi Cristina , Crimì Filippo , Bergamo Marta , Versari Annibale , Lacognata Carmelo , Rea Federico , Barbot Mattia , Scaroni Carla
Published: March 2020

Introduction and aim

Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs) or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of CT with 68Ga-Dota derivatives (68Ga-SSTR) PET in localizing ACTH-secreting tumor in patients with EAS.

Materials and methods

68Ga-SSTR-PET/CT was performed and compared with the nearest enhanced CT in 18 cases (16 primary and 2 recurrent neoplasms). Unspecific, indeterminate and false-positive uptakes were assessed using conventional imaging, follow-up or histology.

Results

We diagnosed 13 thoracic (9 primary and 2 recurrent bronchial carcinoids, 2 SCLCs) and 1 abdominal (pancreatic NET) tumors. Eight ACTH-secreting tumors were promptly identified at EAS diagnosis (’overt’, four pulmonary carcinoids with two recurrences and two SCLC); six EAS have been discovered during the subsequent follow-up (’covert’, five bronchial carcinoids and one pancreatic NET). At the time of EAS diagnosis, imaging was able to correctly detect the ACTH-secreting tumour in 8/18 cases (6 new diagnosis and 2 recurrences). During the follow-up, six out of initially ten ‘occult’ cases became ‘covert’. At last available follow-up, CT and 68Ga-SSTR-PET/CT were able to diagnose 11/18 and 12/18 ACTH-secreting tumours, respectively (11/14 and 12/14 considering only overt and covert cases, respectively). Four cases have never been localized by conventional or nuclear imaging (’occult EAS’), despite an average follow-up of 5 years.

Conclusion

The 68Ga-SSTR-PET/CT is useful in localizing EAS, especially to enhance positive prediction of the suggestive CT lesions and to detect occult neoplasms.
Familial dysalbuminaemic hyperthyroxinaemia interferes with current free thyroid hormone immunoassay methods
Authors: Khoo Serena , Lyons Greta , McGowan Anne , Gurnell Mark , Oddy Susan , Visser W Edward , van den Berg Sjoerd , Halsall David , Taylor Kevin , Chatterjee Krishna , Moran Carla
Published: March 2020

Objective

Familial dysalbuminaemic hyperthyroxinaemia (FDH), most commonly due to an Arginine to Histidine mutation at residue 218 (R218H) in the albumin gene, causes artefactual elevation of free thyroid hormones in euthyroid individuals. We have evaluated the susceptibility of most current free thyroid hormone immunoassay methods used in the United Kingdom, Europe and Far East to interference by R218H FDH.

Methods

Different, one- and two-step immunoassay methods were tested, measuring free T4 (FT4) and free T3 (FT3) in 37 individuals with genetically proven R218H FDH.

Results

With the exception of Ortho VITROS, FT4 measurements were raised in all assays, with greatest to lowest susceptibility to interference being Beckman ACCESS > Roche ELECSYS > FUJIREBIO Lumipulse > Siemens CENTAUR > Abbott ARCHITECT > Perkin-Elmer DELFIA. Five different assays recorded high FT3 levels, with the Siemens CENTAUR method measuring high FT3 values in up to 30% of cases. However, depending on the assay method, FT4 measurements were unexpectedly normal in some, genetically confirmed, affected relatives of index FDH cases.

Conclusions

All FT4 immunoassays evaluated are prone to interference by R218H FDH, with their varying susceptibility not being related to assay architecture but likely due to differing assay conditions or buffer composition. Added susceptibility of many FT3 assays to measurement interference, resulting in high FT4 and FT3 with non-suppressed TSH levels, raises the possibility of R218H FDH being misdiagnosed as resistance to thyroid hormone beta or TSH-secreting pituitary tumour, potentially leading to unnecessary investigation and inappropriate treatment.
The Effect of the Intensity of Telework Use on Employees’ Work-Life Balance
Authors: Grincevičienė Neringa
Published: March 2020

The intensive penetration of information and communication technologies into the labour market has also determined the modernisation of work organization processes. The digitization of information and telecommunications enabled to perform most of intellectual activities not only in the work premises but also in other spaces distant from the main workplace. Thus, as the technology revolution gradually releases modern intellectual work from the constraints of the physical location, telework is becoming an increasingly accelerating trend in the world. Together with technological changes allowing to reach the employee 24 hours a day and 7 days a week create challenges for teleworkers seeking to successfully reconcile two areas of life – work and personal life. Employees from different fields, among them accounting, audit, finances, analysis and others that carry out tasks via telework face this challenge.Relevance of the scientific research problem formulated in this paper was determined by the lack of studies in the scientific research to date, which would evaluate the intensity of telework use as an important factor that has a different effect on work-life balance.The research aim is to reveal the effect of the intensity of telework use on employee work-life balance. A quantitative study – the survey of telework employees was conducted and 320 respondents were surveyed. The results of the empirical study revealed that the intensity of telework use had equally positive effect only on two dimensions of work-life balance: time intended for the family and friends and time intended for oneself.
Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial
Authors: Barlow Karen M. , Brooks Brian L. , Esser Michael J. , Kirton Adam , Mikrogianakis Angelo , Zemek Roger L. , MacMaster Frank P. , Nettel-Aguirre Alberto , Yeates Keith Owen , Kirk Valerie , Hutchison James S. , Crawford Susan , Turley Brenda , Cameron Candice , Hill Michael D. , Samuel Tina , Buchhalter Jeffrey , Richer Lawrence , Platt Robert , Boyd Roslyn , Dewey Deborah
Published: March 2020

BACKGROUND:

Approximately 25% of children with concussion have persistent postconcussive symptoms (PPCS) with resultant significant impacts on quality of life. Melatonin has significant neuroprotective properties, and promising preclinical data suggest its potential to improve outcomes after traumatic brain injury. We hypothesized that treatment with melatonin would result in a greater decrease in PPCS symptoms when compared with a placebo.

METHODS:

We conducted a randomized, double-blind trial of 3 or 10 mg of melatonin compared with a placebo (NCT01874847). We included youth (ages 8–18 years) with PPCS at 4 to 6 weeks after mild traumatic brain injury. Those with significant medical or psychiatric histories or a previous concussion within the last 3 months were excluded. The primary outcome was change in the total youth self-reported Post-Concussion Symptom Inventory score measured after 28 days of treatment. Secondary outcomes included change in health-related quality of life, cognition, and sleep.

RESULTS:

Ninety-nine children (mean age: 13.8 years; SD = 2.6 years; 58% girls) were randomly assigned. Symptoms improved over time with a median Post-Concussion Symptom Inventory change score of −21 (95% confidence interval [CI]: −16 to −27). There was no significant effect of melatonin when compared with a placebo in the intention-to-treat analysis (3 mg melatonin, −2 [95% CI: −13 to 6]; 10 mg melatonin, 4 [95% CI: −7 to 14]). No significant group differences in secondary outcomes were observed. Side effects were mild and similar to the placebo.

CONCLUSIONS:

Children with PPCS had significant impairment in their quality of life. Seventy-eight percent demonstrated significant recovery between 1 and 3 months postinjury. This clinical trial does not support the use of melatonin for the treatment of pediatric PPCS.
Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use
Authors: Mull Eric S. , Erdem Guliz , Nicol Kathleen , Adler Brent , Shell Richard
Published: March 2020

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute eosinophilic pneumonia remains unknown, an acute hypersensitivity reaction to an inhaled antigen is suggested, which is further supported by recent public health risks of vaping (electronic cigarette) use and the development of lung disease. In this case, a patient with a year-long history of vaping in conjunction with tetrahydrocannabinol cartridge use who was diagnosed with idiopathic acute eosinophilic pneumonia with associated bilateral hilar lymphadenopathy is described.
DESENTENDIMIENTO MORAL Y ATRIBUCIÓN DE CULPA: ENCUENTROS Y DESENCUENTROS EN EL ESTUDIO DE LA COGNICIÓN MORAL
Authors: Moreno Romero Camilo Orlando
Published: March 2020

El estudio de la cognición moral pareciera estar marcado por dos tradiciones: una centrada en el estudio del procesamiento de información referente a la causalidad y la intencionalidad, y otra que, con origen en posturas sociocognitivas, privilegia la agencia moral y regulación conductual más allá del procesamiento. Así, pareciera existir una brecha entre el estudio del razonamiento y el estudio de la conducta cuando se habla de moral. La presente propuesta muestra una interacción entre un modelo de culpa (path model) centrado en el procesamiento de información y el Desentendimiento Moral (DM) como un conjunto de mecanismos que surgen para justificar la conducta inmoral. Si bien la integración no es completa, aporta a una visión de la cognición moral centrada en la regulación social y en las interacciones entre juicios y respuestas evidentes en las interacciones sociales. Adicionalmente, como producto de la interacción se presenta una propuesta metodológica para indagar por el origen del DM en el desarrollo.
Improving the Measurement of Children’s Mental Health Problems in Colombia with Item Response Theory
Authors: Cuartas Jorge
Published: March 2020

The present study examines the psychometric properties of the mental health scale for children used in the 2015 Colombian Mental Health Survey. To do so, a nationally representative sample of 2,727 children is used Mage=8.99; range=7-11, with reports from their main caregivers regarding 26 mental health problem symptoms taken from the Reporting Questionnaire for Children (RQC), Child Behavior Checklist (CBCL), and the Brief Screening and Diagnostic Questionnaire (CBTD). Classical test theory and factor analysis were conducted to analyze the classical location and information of each item, along with the dimensionality, reliability, and convergent validity of the scale. Item Response Theory (IRT) was used in order to estimate theoretically invariant item parameters for location and information. Findings reveal that the mental health scale for children has adequate psychometric properties for its use in Colombia. Furthermore, irt analyses reveals a set of items that maximize information and that may be used in future administrations when more efficiency is warranted.
Socio-cultural factors forming marriage motivations of young people (on the example of Saransk)
Authors: Kasarkina Elena N. , Antipova Alyona A.
Published: March 2020

Introduction. The study of marriage intentions in the attitudes of young people summarizes the experience of the past and create a prototype of the future of the family. The style of prenuptial behavior of young people is not isolated, but largely determines the state of the demographic structure of the whole society. The research novelty of the research is that the conceptual empirical analysis of the trends in the culture of family and marriage attitudes of young people and the prospects of its increase in the crisis of family values.
Materials and Methods. The theoretical and methodological basis of the study is represented by a set of concepts and theoretical approaches in accordance with the subject and the problem of the study, which required an appeal to the methodological tools of family sociology, psychology, pedagogy, cultural studies, sociology of youth, demography. When writing the work, general reasearch methods of analysis, synthesis, comparison, generalization, interpretation, system method, secondary analysis of empirical data were used. The author’s empirical research was conducted by the method of questioning. A questionnaire survey of Saransk youth was conducted (300 people).
Results and Discussion. The research has proved the contradiction of the simultaneous influence on the motives and attitudes of premarital behavior of young people of traditional and modern sociocultural norms, attitudes, relationships and relationships is empirically substantiated.
Conclusion. Today young people face a choice of traditional foundations of the family and more radical orientations in the marital and family sphere. As a result, the relations between young adults in the system of premarital behavior are carried out in a difficult situation, which affects marital and family motivation, premarital attitudes and raises the age of marriage. Young people do not have rules of premarital relations enshrined, sanctioned by society and parents. Being the bearer of the innovative potential for the development of society, they have special opportunities for the implementation of their attitudes and needs in the field of premarital behavior.
An adaptation of pseudo-score confidence interval method for linear mixed models
Authors: AKDUR Hatice Tul Kubra , OZONUR Deniz , BAYRAK Hulya
Published: March 2020

We adapt a confidence interval method based on a generalized Chi-Square test for fixed effect parameters of linear mixed models. Under different correlation structure of a response variable of a linear mixed model, the performances of the adaptation method pseudo-score and some of the existing confidence interval methods are investigated by carrying out a Monte Carlo simulation study. The simulation study suggests that pseudo-score method provides better results for small to moderate sample size cases with dependent observations in terms of coverage probability rates and average expected lengths. A depression study is analyzed for demonstrating the adaptation method.
On fourth Hankel determinant for functions associated with Bernoulli's lemniscate
Authors: ARİF M. , UMAR Sadaf , RAZA Mohsan , BULBOACA Teodor , FAROOQ Muhammad Umar , KHAN Hasan
Published: March 2020

The aim of this paper is to find an upper bound of the fourth Hankel determinant $H_{4}(1)$ for a subclass of analytic functions associated with the right half of the Bernoulli's lemniscate of the form $\left(x^{2}+y^{2}\right) ^{2}-2\left( x^{2}-y^{2}\right) =0$. The problem is also discussed for 2-fold and 3-fold symmetric functions. The key tools in the proof of our main results are the coefficient inequalities for class $\mathcal{P}$ of functions with positive real part.***************************************************************************************************************************
Visual research on the trustability of classical variable selection methods in Cox regression
Authors: ATA TUTKUN Nihal , KAYHAN ATILGAN Yasemin
Published: March 2020

Multivariate models such as the Cox regression model, if developed carefully, are powerful tools for making prognostic prediction which are frequently used in studies of clinical outcomes. Many applications require a large number of variables to be modelled by using a relatively small patient sample. Determination of the important variables in a model is critical to understand the behaviour of phenomena as the independent variables contribute the most to the outcome. From a practical perspective, a small subset of independent variables are usually selected from a large data set without the loss of any predictive efficiency. Automatic variable selection algorithms in scientific studies are commonly used for obtaining interpretable and practically applicable models. However, the careless use of these methods may lead to statistical problems. The performance of the generated models may be poor due to the violation of assumption, omission of the important variables, problems of overfitting, and the problem of multicollinearity and outliers. In order to enhance the accuracy of a model, it is essential to explore the data and its main characteristics before making any statistical inference. This study suggests an approach for acquiring a trustworthy model selection procedure for survival data by performing classical variables selection methods, accompanied by a graphical visualization method, namely robust coplot. Thus, it enables us to investigate the discrimination of observations, clusters of the variables and clusters of the observations that are highly characterized by a particular variable in a one graph. We present an application of combined method, as an integral part of statistical modelling, on survival data on multiple myeloma to show how coplot results are used in automatic variable selection algorithm in Cox regression model-building.
Effects on cognitive load of tutoring in virtual reality simulation training
Authors: Andersen Steven Arild Wuyts , Frendø Martin , Sørensen Mads Sølvsten
Published: March 2020

This article was migrated. The article was not marked as recommended. Aims: According to the guidance hypothesis, tutoring during technical skills training can result in tutoring over-reliance, reflected in a negative effect on performance when tutoring is discontinued. In this study, we wanted to explore if similar effects would be found for cognitive load. Methods: Two cohorts of novice medical students were recruited for distributed virtual simulation training (five practice blocks of three procedures): 16 participants received intermittent simulator-integrated tutoring and 14 participants served as a reference cohort and did not receive simulator-integrated tutoring. Cognitive load during simulation was estimated using secondary task reaction time. Linear mixed models were used to account for repeated measurements. Results: Overall, the tutored cohort had a significantly higher cognitive load than the reference cohort (mean difference = 7 %, p=0.006). Simulator-integrated tutoring did seem to lower cognitive load when active but also caused the tutored cohort to have a substantially higher cognitive load in subsequent performances where it was turned off (mean difference = 7 %, respectively, p<<0.001). Conclusions: Concurrent feedback by simulator-integrated tutoring causes tutoring over-reliance and modifies cognitive load. This suggests that tutoring, in addition to degrading motor skills learning also affects the cognitive processes involved.
The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats
Authors: TURAN Fatih , SAYAR İlyas , SALCAN İsmail
Published: March 2020

AbstractBackground/Aims:Tympanosclerosis
is an abnormal tissue reaction resulting in sclerotic and hyalinization changes
in the tympanic membrane and middle ear. 
We hypothesized that alpha lipoic acid, an antioxidant, may represent a
simple and effective form of treatment in inflammattion-related
tympanosclerosis. The purpose of the study was to investigate the effects
of alpha lipoic acid on experimentally induced inflammattion-related tympanosclerosis
in rats.Methods:Twenty
albino Wistar rats were randomly divided into two equal groups. The first
(study) group was administered 50 mg/kg alpha lipoic acid by the intraperitoneal
route once daily for 7 days. The second group was administered the same saline
solution intraperitoneally once daily for 7 days. Inflammation, fibrosis and
lamina propria thickness were assessed at the subsequent histopathological
examination.Results:In
the study group, significantly less middle ear inflammation and fibrosis
developed and the tympanic membrane lamina propria was thinner compared to the control
group. Conclusions: Alpha
lipoic acid was found capable of preventing experimentally induced inflammattion-related
tympanosclerosis with its antioxidant characteristics.
Uso académico de WhatsApp en grupos de estudiantes de ingeniería y arquitectura de una universidad privada
Authors: Lynch Becilla Augusto , Calsín Molleapaza Jose
Published: March 2020

El objetivo de la presente investigación fue determinar el uso de la aplicación WhatsApp en grupo en estudiantes de la Facultad de Ingeniería y Arquitectura de la Universidad Peruana Unión (UPeU), Lurigancho-Chosica, Lima, 2018. La investigación es de tipo básica con enfoque cuantitativo, de diseño no experimental y descriptivo aplicado a una muestra de 304 estudiantes universitarios. Para este estudio se aplicó un cuestionario estandarizado para “WhatsApp en la regulación de trabajo en grupo”, con cuatro dimensiones y 59 ítems, los cuales fueron adaptados y validados por juicio de expertos para evaluar la claridad, dominio de constructo, congruencia y contexto. Los resultados del análisis evidencian que el 68,8 % de los estudiantes poseen un nivel alto en el uso de la aplicación WhatsApp en grupos académicos. Asimismo, en cuanto a las dimensiones de uso de WhatsApp para trabajos grupales, el 67,6 % de los estudiantes evidenciaron un nivel alto: 79,8 % como sistema de comunicación, 71,4 % alto para las relaciones interpersonales, y 42,2% manifiesta que el uso de WhatsApp para trabajos académicos presenta limitaciones. Se concluye que los estudiantes de la Facultad de Ingeniería y Arquitectura de la Universidad Peruana Unión del año 2018, poseen un alto nivel de uso de la aplicación WhatsApp para trabajos en grupos, lo cual representa una herramienta potencial para mejorar y aprovechar en el proceso de comunicación con fines académicos.