bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling and Simulation of the Hysteretic Behavior of Concrete under Cyclic Tension–Compression Using the Smeared Crack Approach
Authors: Zhang Pei , Wang Shenshen , He Luying
Published: June 2023

Concrete structures under wind and earthquake loads will experience tensile and compressive stress reversals. It is very important to accurately reproduce the hysteretic behavior and energy dissipation of concrete materials under cyclic tension–compression for the safety evaluation of concrete structures. A hysteretic model for concrete under cyclic tension–compression is proposed in the framework of smeared crack theory. Based on the crack surface opening–closing mechanism, the relationship between crack surface stress and cracking strain is constructed in a local coordinate system. Linear loading–unloading paths are used and the partial unloading–reloading condition is considered. The hysteretic curves in the model are controlled by two parameters: the initial closing stress and the complete closing stress, which can be determined by the test results. Comparison with several experimental results shows that the model is capable of simulating the cracking process and hysteretic behavior of concrete. In addition, the model is proven to be able to reproduce the damage evolution, energy dissipation, and stiffness recovery caused by crack closure during the cyclic tension–compression. The proposed model can be applied to the nonlinear analysis of real concrete structures under complex cyclic loads.
Seismic Performance and Nonlinear Strain Analysis of Mechanical Splices for High-Strength Reinforcement in Concrete Structures
Authors: Lee Hung-Jen , Chang Tzu-Yu , Chen Chien-Chung , Lin Ker-Chun
Published: June 2023

This study investigates the strain development in reinforcing bars within the plastic hinge regions of beams and columns, with the main objective of modifying the current acceptance criteria for mechanical bar splices to accommodate high-strength reinforcement. The investigation utilizes numerical analysis based on moment–curvature and deformation analysis of typical beam and column sections in a special moment frame. The results indicate that the use of higher grade reinforcement, such as Grade 550 or 690, results in lower strain demands in the plastic hinge regions compared to Grade 420 reinforcement. To validate the modified seismic loading protocol, over 100 samples of mechanical coupling systems were tested in Taiwan. The test results demonstrate that the majority of these systems can successfully complete the modified seismic loading protocol and are suitable for use in critical plastic hinge regions of special moment frames. However, caution is advised for slender mortar-grouted coupling sleeves, as they were unable to fulfill the seismic loading protocols. These sleeves may be conditionally used in plastic hinge regions of precast columns, provided they meet specific conditions and demonstrate seismic performance through structural testing. The findings of this study offer valuable insight into the design and application of mechanical splices in high-strength reinforcement scenarios.
Structure and Phase Composition of WNb Alloy Formed by the Impact of Compression Plasma Flows
Authors: Ryskulov Azamat , Shymanski Vitaliy , Uglov Vladimir , Ivanov Igor , Astashynski Valiantsin , Amanzhulov Bauyrzhan , Kuzmitski Anton , Kurakhmedov Alisher , Filipp Andrei , Ungarbayev Yerulan , Koloberdin Mikhail
Published: June 2023

The results of a tungsten–niobium alloy synthesis by the impact of pulsed compression plasma flows are presented. Tungsten plates with a 2 μm thin niobium coating were treated with dense compression plasma flows generated by a quasi-stationary plasma accelerator. The plasma flow with an absorbed energy density of 35–70 J/cm2 and pulse duration of 100 μs melted the niobium coating and a part of the tungsten substrate, which caused liquid-phase mixing and WNb alloy synthesis. Simulation of the temperature distribution in the top layer of the tungsten after the plasma treatment proved the formation of the melted state. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to determine the structure and phase composition. The thickness of the WNb alloy was 10–20 μm and a W(Nb) bcc solid solution was found.
Graphene-Based Materials for the Separator Functionalization of Lithium-Ion/Metal/Sulfur Batteries
Authors: Huang Zongle , Sun Wenting , Sun Zhipeng , Ding Rui , Wang Xuebin
Published: June 2023

With the escalating demand for electrochemical energy storage, commercial lithium-ion and metal battery systems have been increasingly developed. As an indispensable component of batteries, the separator plays a crucial role in determining their electrochemical performance. Conventional polymer separators have been extensively investigated over the past few decades. Nevertheless, their inadequate mechanical strength, deficient thermal stability, and constrained porosity constitute serious impediments to the development of electric vehicle power batteries and the progress of energy storage devices. Advanced graphene-based materials have emerged as an adaptable solution to these challenges, owing to their exceptional electrical conductivity, large specific surface area, and outstanding mechanical properties. Incorporating advanced graphene-based materials into the separator of lithium-ion and metal batteries has been identified as an effective strategy to overcome the aforementioned issues and enhance the specific capacity, cycle stability, and safety of batteries. This review paper provides an overview of the preparation of advanced graphene-based materials and their applications in lithium-ion, lithium-metal, and lithium-sulfur batteries. It systematically elaborates on the advantages of advanced graphene-based materials as novel separator materials and outlines future research directions in this field.
Enhanced Hydrogen Generation from Magnesium–Aluminum Scrap Ball Milled with Low Melting Point Solder Alloy
Authors: Buryakovskaya Olesya A. , Ambaryan Grayr N. , Suleimanov Musi Zh. , Tarasenko Alexey B. , Vlaskin Mikhail S.
Published: June 2023

In this investigation, composite materials were manufactured of mixed scrap of Mg-based alloys and low melting point Sn–Pb eutectic by high energy ball milling, and their hydrogen generation performance was tested in NaCl solution. The effects of the ball milling duration and additive content on their microstructure and reactivity were investigated. Scanning electron microscopy (SEM) analysis indicated notable structural transformations of the particles during ball milling, and X-ray diffraction analysis (XRD) proved the formation of new intermetallic phases Mg2Sn and Mg2Pb, which were aimed to augment galvanic corrosion of the base metal. The dependency of the material’s reactivity on the activation time and additive content occurred to be non-monotonic. For all tested samples ball milling during the 1 h provided, the highest hydrogen generation rates and yields as compared to 0.5 and 2 h and compositions with 5 wt.% of the Sn–Pb alloy, demonstrated higher reactivity than those with 0, 2.5, and 10 wt.%.
Experimental Investigation and Modeling of Force-Induced Surface Errors for the Robot-Assisted Milling Process
Authors: Jin Yongqiao , Gu Qunfei , Liu Shun , Yang Changqi
Published: June 2023

A series of experiments were performed aiming at controlling milling force-induced surface errors in the robot-assisted milling process, for the sub-area of the multi-stiffener reinforced inner wall of complex cylindrical thin-walled casting parts, to investigate the relationship between surface errors, milling forces, and robot-assisted milling parameters. Firstly, based on the design of experiments (DoE) method, milling forces and surface errors were investigated based on a series of experiments with different groups of milling parameters. Secondly, the modeling of milling forces, surface errors, and milling parameters was realized by means of response surface methodology (RSM), then the parametric expression was obtained of the robot-assisted milling process. Finally, the parameters of the milling process toward the surface error were obtained based on an evolutionary algorithm. The results show that the surface errors are different for the different milling styles of down milling and up milling. In up milling processes, the surface errors are positive, and the actual material removal amounts are generally higher than the nominal ones, while negative in down milling processes. The surface errors induced by milling forces can be effectively controlled and reduced using process optimization in the robot-assisted milling process, while maintaining relatively high milling forces and high machining efficiency. This provides theoretical support for industry applications.
Field Complete Coverage Path Planning Based on Improved Genetic Algorithm for Transplanting Robot
Authors: Wu Xizhi , Bai Jinqiang , Hao Fengqi , Cheng Guanghe , Tang Yongwei , Li Xiuhua
Published: June 2023

The Complete Coverage Path Planning (CCPP) is a key technology in the field of agricultural robots, and has great significance for improving the efficiency and quality of tillage, fertilization, harvesting, and other agricultural robot operations, as well as reducing the operation energy consumption. The traditional boustrophedon- or heuristic-search-algorithm-based CCPP methods, when coping with the field with irregular boundaries, obstacles, and other complex environments, still face many problems and challenges, such as large repeated work areas, multiple turns or U-turns, low operation efficiency, and prone to local optimum. In order to solve the above problems, an improved-genetic-algorithm-based CCPP method was proposed in this paper, the proposed method innovatively extends the traditional genetic algorithm’s chromosomes and single-point mutation into chromosome pairs and multi-point mutation, and proposed a multi-objective equilibrium fitness function. The simulation and experimental results on simple regular fields showed that the proposed improved-genetic-algorithm-based CCPP method achieved the comparable performance with the traditional boustrophedon-based CCPP method. However, on the complex irregular fields, the proposed CCPP method reduces 38.54% of repeated operation area and 35.00% of number of U-turns, and can save 7.82% of energy consumption on average. This proved that the proposed CCPP method has a strong adaptive capacity to the environment, and has practical application value in improving the efficiency and quality of agricultural machinery operations, and reducing the energy consumption.
Property (h) of Banach Lattice and Order-to-Norm Continuous Operators
Authors: Zhang Fu , Shen Hanhan , Chen Zili
Published: June 2023

In this paper, we introduce the property (h) on Banach lattices and present its characterization in terms of disjoint sequences. Then, an example is given to show that an order-to-norm continuous operator may not be σ-order continuous. Suppose T:E→F is an order-bounded operator from Dedekind σ-complete Banach lattice E into Dedekind complete Banach lattice F. We prove that T is σ-order-to-norm continuous if and only if T is both order weakly compact and σ-order continuous. In addition, if E can be represented as an ideal of L0(μ), where (Ω,Σ,μ) is a σ-finite measure space, then T is σ-order-to-norm continuous if and only if T is order-to-norm continuous. As applications, we extend Wickstead’s results on the order continuity of norms on E and E′.
On the Uniqueness of the Bounded Solution for the Fractional Nonlinear Partial Integro-Differential Equation with Approximations
Authors: Li Chenkuan , Saadati Reza , Beaudin Joshua , Hrytsenko Andrii
Published: June 2023

This paper studies the uniqueness of the bounded solution to a new Cauchy problem of the fractional nonlinear partial integro-differential equation based on the multivariate Mittag–Leffler function as well as Banach’s contractive principle in a complete function space. Applying Babenko’s approach, we convert the fractional nonlinear equation with variable coefficients to an implicit integral equation, which is a powerful method of studying the uniqueness of solutions. Furthermore, we construct algorithms for finding analytic and approximate solutions using Adomian’s decomposition method and recurrence relation with the order convergence analysis. Finally, an illustrative example is presented to demonstrate constructions for the numerical solution using MATHEMATICA.
Application of STEM Technologies on the Example of the Problem of a Thread with a Load
Authors: Ochkov Valery , Vasileva Inna , Borovinskaya Ekaterina , Reschetilowski Wladimir
Published: June 2023

This paper demonstrates the application of STEM technologies using the example of the problem of a thread with a load. As a training problem, parameter finding of a flexible inextensible thread with a load sliding along it, as well as with a fixed load, is considered. A mathematical model of a thread with a load is created without using simplifying assumptions such as a negligibly small mass of the thread, a thread with a small sag or a parabolic approximation of the thread form. When solving the problem, methods of analysis from various branches of mathematics, theoretical mechanics, physics, history of mathematics, as well as various tools of computer mathematical packages (Mathcad), are used. The reasonability of considering such tasks from the perspective of teaching effectiveness for first-year students in engineering as well as in physics and mathematics is proved. Promising educational tasks based on the investigated problem are considered.
New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle
Authors: Yu Jia-Dong , Yu Dan-Dan , Su Ming-Zhi , Gu Yu-Cheng , Wang Hong , Guo Yue-Wei
Published: June 2023

Fifteen new diterpenoids, namely xishaklyanes A-O (1–15), along with three known related ones (16–18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher’s method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 μg/mL against Lactococcus garvieae.
Extracranial Facial Nerve Schwannoma—Histological Surprise or Therapeutic Planning?
Authors: Vrinceanu Daniela , Dumitru Mihai , Popa-Cherecheanu Matei , Marinescu Andreea Nicoleta , Patrascu Oana-Maria , Bobirca Florin
Published: June 2023

Schwannomas (neurilemomas) are benign, slow-growing, encapsulated, white, yellow, or pink tumors originating in Schwann cells in the sheaths of cranial nerves or myelinated peripheral nerves. Facial nerve schwannomas (FNS) can form anywhere along the course of the nerve, from the pontocerebellar angle to the terminal branches of the facial nerve. In this article, we propose a review of the specialized literature regarding the diagnostic and therapeutic management of schwannomas of the extracranial segment of the facial nerve, also presenting our experience in this type of rare neurogenic tumor. The clinical exam reveals pretragial swelling or retromandibular swelling, the extrinsic compression of the lateral oropharyngeal wall like a parapharyngeal tumor. The function of the facial nerve is generally preserved due to the eccentric growth of the tumor pushing on the nerve fibers, and the incidence of peripheral facial paralysis in FNSs is described in 20–27% of cases. Magnetic Resonance Imaging (MRI) examination is the gold standard and describes a mass with iso signal to muscle on T1 and hyper signal to muscle on T2 and a characteristic “darts sign.” The most practical differential diagnoses are pleomorphic adenoma of the parotid gland and glossopharyngeal schwannoma. The surgical approach to FNSs requires an experienced surgeon, and radical ablation by extracapsular dissection with preservation of the facial nerve is the gold standard for the cure. The patient’s informed consent is important regarding the diagnosis of schwannoma and the possibility of facial nerve resection with reconstruction. Frozen section intraoperative examination is necessary to rule out malignancy or when sectioning of the facial nerve fibers is necessary. Alternative therapeutic strategies are imaging monitoring or stereotactic radiosurgery. The main factors which are considered during the management are the extension of the tumor, the presence or not of facial palsy, the experience of the surgeon, and the patient’s options.
Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Authors: Santoro Rita , Molinari Angelo , Leotta Marzia , Martini Tiziano
Published: June 2023

Activated partial thromboplastin time (aPTT) is a fundamental screening test for coagulation disturbances. An increased aPTT ratio is quite common in clinical practice. How the detection of prolonged activated aPTT with a normal prothrombin time is interpreted is therefore very important. In daily practice, the detection of this abnormality often leads to delayed surgery and emotional stress for patients and their families and may be associated with increased costs due to re-testing and coagulation factor assessment. An isolated, prolonged aPTT is seen in (a) patients with congenital or acquired deficiencies of specific coagulation factors, (b) patients receiving treatment with anticoagulants, mainly heparin, and (c) individuals/patients with circulating anticoagulants. We summarize here what may cause an isolated prolonged aPTT and evaluate the preanalytical interferences. The identification of the cause of an isolated prolonged aPTT is of the utmost importance in ensuring the correct diagnostic workup and therapeutic choices.
Experimental Trypanosoma cruzi Infection and Chagas Disease—A Word of Caution
Authors: Talvani André , Teixeira Mauro Martins
Published: June 2023

The physician Carlos Chagas (1879–1934) described the protozoan parasite Trypanosoma cruzi and discovered a new illness named American trypanosomiases or Chagas disease (Chagas, 1909) [...]
Synthesis and Structural Characterization of Copper Complexes Containing “R-Substituted” Bis-7-Azaindolyl Borate Ligands
Authors: Jackson Miriam , Thomas Simon D. , Tizzard Graham J. , Coles Simon J. , Owen Gareth R.
Published: June 2023

The coordination chemistry of scorpionate ligands based on borates containing the 7-azaindole heterocycle is relatively unexplored. Thus, there is a requirement to further understand their coordination chemistry. This article outlines the synthesis and characterization of a family of complexes containing anionic flexible scorpionate ligands of the type [(R)(bis-7-azaindolyl)borohydride]− ([RBai]−), where R = Me, Ph or naphthyl. The three ligands were coordinated to a series of copper(I) complexes containing a phosphine co-ligand to form the complexes, [Cu(MeBai)(PPh3)] (1), [Cu(PhBai)(PPh3)] (2), [Cu(NaphthBai)(PPh3)] (3), [Cu(MeBai)(PCy3)] (4), [Cu(PhBai)(PCy3)] (5) and [Cu(NaphthBai)(PCy3)] (6). Additional copper(II) complexes, namely, [Cu(MeBai)2] (7) and [Cu(PhBai)2] (8), were obtained during attempts to obtain single crystals from complexes 4 and 2, respectively. Complexes 7 and 8 were also prepared independently from CuCl2 and two equivalents of the corresponding Li[RBai] salt alongside an additional complex, namely, [Cu(NaphthBai)2] (9). The copper(I) and copper(II) complexes were characterized using spectroscopic and analytical methods. Furthermore, a crystal structure was obtained for eight of the nine complexes. In all cases, the boron-based ligand was found to bind to the metal centers via a κ3-N,N,H coordination mode.
The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
Authors: Balis Peter , Berenyiova Andrea , Misak Anton , Grman Marian , Rostakova Zuzana , Waczulikova Iveta , Cacanyiova Sona , Domínguez-Álvarez Enrique , Ondrias Karol
Published: June 2023

Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H2Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg−1), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dtmax relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dtmin delay, dP/dtd delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L−1) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.
New Insights into the Opioid Analgesic Profile of cis-(−)-N-Normetazocine-derived Ligands
Authors: Costanzo Giuliana , Turnaturi Rita , Parenti Carmela , Spoto Salvatore , Piana Silvia , Dichiara Maria , Zagni Chiara , Galambos Anna Rita , Essmat Nariman , Marrazzo Agostino , Amata Emanuele , Al-Khrasani Mahmoud , Pasquinucci Lorella
Published: June 2023

In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of our lead compound LP1 was replaced by an electron-rich or electron-deficient ring and linked through a propanamide or butyramide spacer at the basic nitrogen of the (−)-cis-N-normetazocine skeleton. In radioligand binding assays, compounds 3 and 7 were found to display nanomolar binding affinity for the μ opioid receptor (MOR) (Ki = 5.96 ± 0.08 nM and 1.49 ± 0.24 nM, respectively). In the mouse vas deferens (MVD) assay, compound 3 showed an antagonist effect against DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin), a highly selective MOR prototype agonist, whereas compound 7 produced naloxone reversible effect at MOR. Moreover, compound 7, as potent as LP1 and DAMGO at MOR, was able to reduce thermal and inflammatory pain assessed by the mouse tail-flick test and rat paw pressure thresholds (PPTs) measured by a Randall–Selitto test.
Tröger’s Base-Derived Thermally Activated Delayed Fluorescence Dopant for Efficient Deep-Blue Organic Light-Emitting Diodes
Authors: Wu Ze-Ling , Lv Xin , Meng Ling-Yi , Chen Xu-Lin , Lu Can-Zhong
Published: June 2023

The development of efficient deep-blue emitters with thermally activated delayed fluorescence (TADF) properties is a highly significant but challenging task in the field of organic light-emitting diode (OLED) applications. Herein, we report the design and synthesis of two new 4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine (TB)-derived TADF emitters, TB-BP-DMAC and TB-DMAC, which feature distinct benzophenone (BP)-derived acceptors but share the same dimethylacridin (DMAC) donors. Our comparative study reveals that the amide acceptor in TB-DMAC exhibits a significantly weaker electron-withdrawing ability in comparison to that of the typical benzophenone acceptor employed in TB-BP-DMAC. This disparity not only causes a noticeable blue shift in the emission from green to deep blue but also enhances the emission efficiency and the reverse intersystem crossing (RISC) process. As a result, TB-DMAC emits efficient deep-blue delay fluorescence with a photoluminescence quantum yield (PLQY) of 50.4% and a short lifetime of 2.28 μs in doped film. The doped and non-doped OLEDs based on TB-DMAC display efficient deep-blue electroluminescence with spectral peaks at 449 and 453 nm and maximum external quantum efficiencies (EQEs) of 6.1% and 5.7%, respectively. These findings indicate that substituted amide acceptors are a viable option for the design of high-performance deep-blue TADF materials.
Computational Modeling of DNA 3D Structures: From Dynamics and Mechanics to Folding
Authors: Mu Zi-Chun , Tan Ya-Lan , Liu Jie , Zhang Ben-Gong , Shi Ya-Zhou
Published: June 2023

DNA carries the genetic information required for the synthesis of RNA and proteins and plays an important role in many processes of biological development. Understanding the three-dimensional (3D) structures and dynamics of DNA is crucial for understanding their biological functions and guiding the development of novel materials. In this review, we discuss the recent advancements in computer methods for studying DNA 3D structures. This includes molecular dynamics simulations to analyze DNA dynamics, flexibility, and ion binding. We also explore various coarse-grained models used for DNA structure prediction or folding, along with fragment assembly methods for constructing DNA 3D structures. Furthermore, we also discuss the advantages and disadvantages of these methods and highlight their differences.
Influence of Al2O3 Overlayers on Intermolecular Interactions between Metal Oxide Bound Molecules
Authors: Knorr Erica S. , Basquill Cody T. , Bertini Isabella A. , Arcidiacono Ashley , Beery Drake , Wheeler Jonathan P. , Winfred J. S. Raaj Vellore , Strouse Geoffrey F. , Hanson Kenneth
Published: June 2023

Intermolecular interactions on inorganic substrates can have a critical impact on the electrochemical and photophysical properties of the materials and subsequent performance in hybrid electronics. Critical to the intentional formation or inhibition of these processes is controlling interactions between molecules on a surface. In this report, we investigated the impact of surface loading and atomic-layer-deposited Al2O3 overlayers on the intermolecular interactions of a ZrO2-bound anthracene derivative as probed by the photophysical properties of the interface. While surface loading density had no impact on the absorption spectra of the films, there was an increase in excimer features with surface loading as observed by both emission and transient absorption. The addition of ALD overlayers of Al2O3 resulted in a decrease in excimer formation, but the emission and transient absorption spectra were still dominated by excimer features. These results suggest that ALD may provide a post-surface loading means of influencing such intermolecular interactions.
Preclinical EIS Study of the Inflammatory Response Evolution of Pure Titanium Implant in Hank’s Biological Solution
Authors: Benea Lidia , Bounegru Iulian , Forray Alexandra , Axente Elena Roxana , Buruiana Daniela Laura
Published: June 2023

Pure titanium (Ti) is investigated in a pre-clinical study in Hank’s biological solution using electrochemical methods, open circuit potential, and electrochemical impedance spectroscopy to highlight the time effect in extreme body conditions, such as inflammatory diseases, on degradability due to corrosion processes occurring on the titanium implant. Electrochemical impedance spectroscopy (EIS) data are presented as Nyquist and Bode plots. The results show the increasing reactivity of titanium implants in the presence of hydrogen peroxide, which is an oxygen-reactive compound that describes inflammatory conditions. The polarization resistance, which results from electrochemical impedance spectroscopy measurements, declined dramatically from the highest value registered in Hank’s solution to smaller values registered in all solutions when different concentrations of hydrogen peroxide were tested. The EIS analysis provided insights into titanium’s in vitro corrosion behavior as an implanted biomaterial, which could not be solely obtained through potentiodynamic polarization testing.
Biogenic Synthesis of Copper Nanoparticles: A Systematic Review of Their Features and Main Applications
Authors: Luque-Jacobo Cristina M. , Cespedes-Loayza Andrea L. , Echegaray-Ugarte Talia S. , Cruz-Loayza Jacqueline L. , Cruz Isemar , de Carvalho Júlio Cesar , Goyzueta-Mamani Luis Daniel
Published: June 2023

Nanotechnology is an innovative field of study that has made significant progress due to its potential versatility and wide range of applications, precisely because of the development of metal nanoparticles such as copper. Nanoparticles are bodies composed of a nanometric cluster of atoms (1–100 nm). Biogenic alternatives have replaced their chemical synthesis due to their environmental friendliness, dependability, sustainability, and low energy demand. This ecofriendly option has medical, pharmaceutical, food, and agricultural applications. When compared to their chemical counterparts, using biological agents, such as micro-organisms and plant extracts, as reducing and stabilizing agents has shown viability and acceptance. Therefore, it is a feasible alternative for rapid synthesis and scaling-up processes. Several research articles on the biogenic synthesis of copper nanoparticles have been published over the past decade. Still, none provided an organized, comprehensive overview of their properties and potential applications. Thus, this systematic review aims to assess research articles published over the past decade regarding the antioxidant, antitumor, antimicrobial, dye removal, and catalytic activities of biogenically synthesized copper nanoparticles using the scientific methodology of big data analytics. Plant extract and micro-organisms (bacteria and fungi) are addressed as biological agents. We intend to assist the scientific community in comprehending and locating helpful information for future research or application development.
Skin Pigmentation Types, Causes and Treatment—A Review
Authors: Thawabteh Amin Mahmood , Jibreen Alaa , Karaman Donia , Thawabteh Alà , Karaman Rafik
Published: June 2023

Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted by genetics, UV exposure, and some drugs. Patients’ physical appearance, psychological health, and social functioning are all impacted by a sizable number of skin conditions that cause pigmentary abnormalities. Hyperpigmentation, where pigment appears to overflow, and hypopigmentation, where pigment is reduced, are the two major classifications of skin pigmentation. Albinism, melasma, vitiligo, Addison’s disease, and post-inflammatory hyperpigmentation, which can be brought on by eczema, acne vulgaris, and drug interactions, are the most common skin pigmentation disorders in clinical practice. Anti-inflammatory medications, antioxidants, and medications that inhibit tyrosinase, which prevents the production of melanin, are all possible treatments for pigmentation problems. Skin pigmentation can be treated orally and topically with medications, herbal remedies, and cosmetic products, but a doctor should always be consulted before beginning any new medicine or treatment plan. This review article explores the numerous types of pigmentation problems, their causes, and treatments, as well as the 25 plants, 4 marine species, and 17 topical and oral medications now on the market that have been clinically tested to treat skin diseases.
An Innovative Polarisation-Insensitive Perfect Metamaterial Absorber with an Octagonal-Shaped Resonator for Energy Harvesting at Visible Spectra
Authors: Hossain Mohammad Jakir , Rahman Md. Habibur , Faruque Mohammad Rashed Iqbal
Published: June 2023

Perfect metamaterial absorber (PMA) is an attractive optical wavelength absorber with potential solar energy and photovoltaic applications. Perfect metamaterials used as solar cells can improve efficiency by amplifying incident solar waves on the PMA. This study aims to assess a wide-band octagonal PMA for a visible wavelength spectrum. The proposed PMA consists of three layers: nickel, silicon dioxide, and nickel. Based on the simulations, polarisation-insensitive absorption transverse electric (TE) and transverse magnetic (TM) modes were achieved due to symmetry. The proposed PMA structure was subjected to computational simulation using a FIT-based CST simulator. The design structure was again confirmed using FEM-based HFSS to maintain pattern integrity and absorption analysis. The absorption rates of the absorber were estimated at 99.987% and 99.997% for 549.20 THz and 653.2 THz, respectively. The results indicated that the PMA could achieve high absorption peaks in TE and TM modes despite being insensitive to polarisation and the incident angle. Electric field and magnetic field analyses were performed to understand the absorption of the PMA for solar energy harvesting. In conclusion, the PMA possesses outstanding visible frequency absorption, making it a promising option.
Impact of the Family Environment on the Frequency of Animal-Based Product Consumption in School-Aged Children in Central Poland
Authors: Pałkowska-Goździk Ewelina , Zadka Katarzyna , Rosołowska-Huszcz Danuta
Published: June 2023

Animal-sourced foods (ASFs) have a high nutritional value, which makes them important elements of young people’s diets. Several environmental factors might affect the dietary habits of children and adolescents, and their identification seems to be a principal reason to maintain their healthy eating practice. Thus, we aimed to investigate selected environmental factors (a place of residence, net income, mother’s education level, number of siblings, and mother’s BMI), which may be linked to the consumption frequency of ASFs among school-aged children. In total, 892 mothers of primary school children aged 7–14 years from central Poland took part in the anonymous and voluntary survey. The frequency of meat and meat product consumption was affected by the mother’s education level, place of residence, and net income. Generally, meat was eaten more often by the city children (G = 0.178, p < 0.01) of better-educated mothers (G = 0.268, p < 0.001) and higher-income families (G = 0.209, p < 0.001). A higher level of education was linked to more frequent fish consumption but only in the younger group (G = 0.130, p < 0.05). The frequency of egg intake was positively associated with the maternal level of education (G = 0.185, p < 0.001), children’s gender (girls > boys, G = 0.123, p < 0.05), and place of residence (city > village, G = 0.214, p < 0.001). In turn, the frequency of milk and dairy intake was related only to the place of residence (village > city, G = 0.97, p <0.05). It can be concluded that the mother’s level of education is a key factor linked to the selected children’s dietary habits. Thus, we believe that successful health education programs designed for young people should include the maternal capacity to interpret and adapt information into daily practice.
Relationships of Body Mass Index, Relative Fat Mass Index, and Waist Circumference with Serum Concentrations of Parameters of Chronic Inflammation
Authors: Kamińska Magdalena Sylwia , Lubkowska Anna , Panczyk Mariusz , Walaszek Ireneusz , Grochans Szymon , Grochans Elżbieta , Cybulska Anna Maria
Published: June 2023

(1) Background: Obesity in the perimenopausal period is associated with hormonal changes, lifestyle, and environment. In obesity, elevated levels of IL-6 and TNF-α and reduced levels of adiponectin are observed, and the associated chronic inflammation favors the development of cardiometabolic diseases. Therefore, the aim of our study was to assess the relationship between selected measures of obesity (BMI, WC, RFM, VAI, WHtR) and parameters of chronic inflammation (CRP, TNF-α, IL-6) in perimenopausal women. (2) Methods: The study involved 172 perimenopausal women. The methods used in this study were diagnostic surveys, anthropometric measurements, blood pressure measurements, and venous blood sampling. (3) Results: Preliminary multivariate linear regression analysis showed that CRP moderately positively correlated with IL-6 (β = 0.25; p = 0.001) and weakly negatively correlated with adiponectin (β = −0.23; p = 0.002). Similar associations were noted in preliminary multivariate linear regression analysis adjusted for age, menopausal status, and smoking status. Preliminary multivariate linear regression analysis also showed that BMI positively correlated with IL-6 (β = 0.16; p = 0.033). VAI weakly positively correlated with CRP (β = 0.25; p = 0.001) and negatively correlated with adiponectin (β = −0.43; p = 0.000). (4) BMI, WC, RFM, VAI, and WHtR are clearly related to selected parameters of chronic inflammation. Our study suggests that each of the anthropometric variables provides distinct information on metabolic processes associated with inflammatory parameters.
Maternal Exercise Impacts Offspring Metabolic Health in Adulthood: A Systematic Review and Meta-Analysis of Animal Studies
Authors: Ding Lu , Liu Jieying , Zhou Liyuan , Xiao Xinhua
Published: June 2023

Maternal exercise benefits offspring’s metabolic health with long-term repercussions. Here, we systematically reviewed the effects of maternal exercise on offspring obesity outcomes in adulthood. The primary outcome is body weight. The secondary outcomes are glucose and lipid profiles. Two independent authors performed a search in the databases PubMed, EMBASE, and Web of Science. A total of nine studies with 17 different cohorts consisting of 369 animals (two species) were included. Study quality was assessed using the SYRCLE risk of bias. The PRISMA statement was used to report this systematic review. The results showed that maternal exercise contributes to improved glucose tolerance, reduced insulin concentration, and lower total cholesterol and low density lipoprotein levels in adult offspring in mice, which are independent of maternal body weight and offspring dietary condition. Additionally, in rats, maternal exercise leads to a higher body weight in adult offspring, which might be attributed to the high-fat diet of offspring after weaning. These findings further support the metabolic beneficial role of maternal exercise on offspring in adulthood, although the issue of translating the results to the human population is still yet to be addressed.
Prevalence, Serotypes, Antimicrobial Resistance and Biofilm-Forming Ability of Listeria monocytogenes Isolated from Bulk-Tank Bovine Milk in Northern Greece
Authors: Angelidis Apostolos S. , Grammenou Afroditi S. , Kotzamanidis Charalampos , Giadinis Nektarios D. , Zdragas Antonios G. , Sergelidis Daniel
Published: June 2023

The prevalence of Listeria monocytogenes in bovine bulk-tank milk (BTM) in Greece has not been previously investigated. The aim of the study was to estimate the prevalence of L. monocytogenes in bovine BTM in Greece and to characterize the isolates in terms of carriage of genes encoding for pathogenic determinants, assess the isolates’ biofilm-forming ability and determine their susceptibility against 12 antimicrobials. Samples (n = 138) of bovine BTM were obtained from farms located throughout Northern Greece and were analyzed qualitatively and quantitatively for L. monocytogenes. Five samples (3.6%) tested positive for L. monocytogenes. The pathogen’s populations in these positive samples were below 5 CFU/mL. Most isolates belonged to the molecular serogroup “1/2a, 3a”. All isolates carried the virulence genes inlA, inlC, inlJ, iap, plcA and hlyA, but actA was detected in only three isolates. The isolates displayed weak to moderate biofilm-forming ability and distinct antimicrobial resistance profiles. All isolates were characterized as multidrug resistant, with resistance to penicillin and clindamycin being a common feature. Considering that L. monocytogenes constitutes a serious public health threat, the key findings of the study, related to the carriage of virulence genes and multidrug resistance, highlight the importance of continued monitoring of the pathogen in farm animals.
Clinical Use of Intravenous Fosfomycin in Critical Care Patients in Taiwan
Authors: Chen Tzu-Ting , Chang Yun-Fu , Wu Yea-Chwen
Published: June 2023

This retrospective study aimed to evaluate the clinical use and side effects of fosfomycin in critically ill patients in Taiwan. Forty-two patients (mean age, 69.9 years; female, 69%) who received fosfomycin were included from a teaching hospital in Taiwan from January 2021 to December 2021. We analyzed the prescription pattern of intravenous fosfomycin and evaluated patient safety profiles, clinical successes, and microbiological cure rates. The main indication was urinary tract infections (35.6%), and the most frequently identified pathogen was Escherichia coli (18.2%). The overall clinical success was 83.4%, with one multidrug-resistant pathogen isolated from eight patients (19.0%). The average dose of fosfomycin given was 11.1 ± 5.2 g/day. The average duration of therapy was 8.7 ± 5.9 days, with a median duration of 8 days, where fosfomycin was mostly (83.3%) given in combination. Fosfomycin was given 12 hourly to a maximum number (47.6%) of cases. The incidence rates of adverse drug reactions (hypernatremia and hypokalemia) were 33.33% (14/42) and 28.57% (12/42), respectively. The overall survival rate was 73.8%. Intravenous fosfomycin may be an effective and safe antibiotic to use in combination with other drugs for empirical broad-spectrum or highly suspected multidrug-resistant infections in critically ill patients.
Discovery of Terpenes as Novel HCV NS5B Polymerase Inhibitors via Molecular Docking
Authors: Karpiński Tomasz M. , Ożarowski Marcin , Silva Pedro J. , Stasiewicz Mark , Alam Rahat , Samad Abdus
Published: June 2023

Hepatitis C virus (HCV) is a dangerous virus that is responsible for a large number of infections and deaths worldwide. In the treatment of HCV, it is important that the drugs are effective and do not have additional hepatotoxic effects. The aim of this study was to test the in silico activity of 1893 terpenes against the HCV NS5B polymerase (PDB-ID: 3FQK). Two drugs, sofosbuvir and dasabuvir, were used as controls. The GOLD software (CCDC) and InstaDock were used for docking. By using the results obtained from PLP.Fitness (GOLD), pKi, and binding free energy (InstaDock), nine terpenes were finally selected based on their scores. The drug-likeness properties were calculated using Lipinski’s rule of five. The ADMET values were studied using SwissADME and pkCSM servers. Ultimately, it was shown that nine terpenes have better docking results than sofosbuvir and dasabuvir. These were gniditrin, mulberrofuran G, cochlearine A, ingenol dibenzoate, mulberrofuran G, isogemichalcone C, pawhuskin B, 3-cinnamyl-4-oxoretinoic acid, DTXSID501019279, and mezerein. Each docked complex was submitted to 150 ns-long molecular dynamics simulations to ascertain the binding stability. The results show that mulberrofuran G, cochlearine A, and both stereoisomers of pawhuskin B form very stable interactions with the active site region where the reaction product should form and are, therefore, good candidates for use as effective competitive inhibitors. The other compounds identified in the docking screen either afford extremely weak (or even hardly any) binding (such as ingenol dibenzoate, gniditrin, and mezerein) or must first undergo preliminary movements in the active site before attaining their stable binding conformations, in a process which may take from 60 to 80 ns (for DTXSID501019279, 3-cinnamyl-4-oxoretinoic acid or isogemichalcone C).
Inhibition of TRPA1, Endoplasmic Reticulum Stress, Human Airway Epithelial Cell Damage, and Ectopic MUC5AC Expression by Vasaka (Adhatoda vasica; Malabar Nut) Tea
Authors: Memon Tosifa A. , Sun Lili , Almestica-Roberts Marysol , Deering-Rice Cassandra E. , Moos Philip J. , Reilly Christopher A.
Published: June 2023

This study tested whether a medicinal plant, Vasaka, typically consumed as a tea to treat respiratory malaise, could protect airway epithelial cells (AECs) from wood smoke particle-induced damage and prevent pathological mucus production. Wood/biomass smoke is a pneumotoxic air pollutant. Mucus normally protects the airways, but excessive production can obstruct airflow and cause respiratory distress. Vasaka tea pre- and co-treatment dose-dependently inhibited mucin 5AC (MUC5AC) mRNA induction by AECs treated with wood smoke particles. This correlated with transient receptor potential ankyrin-1 (TRPA1) inhibition, an attenuation of endoplasmic reticulum (ER) stress, and AEC damage/death. Induction of mRNA for anterior gradient 2, an ER chaperone/disulfide isomerase required for MUC5AC production, and TRP vanilloid-3, a gene that suppresses ER stress and wood smoke particle-induced cell death, was also attenuated. Variable inhibition of TRPA1, ER stress, and MUC5AC mRNA induction was observed using selected chemicals identified in Vasaka tea including vasicine, vasicinone, apigenin, vitexin, isovitexin, isoorientin, 9-oxoODE, and 9,10-EpOME. Apigenin and 9,10-EpOME were the most cytoprotective and mucosuppressive. Cytochrome P450 1A1 (CYP1A1) mRNA was also induced by Vasaka tea and wood smoke particles. Inhibition of CYP1A1 enhanced ER stress and MUC5AC mRNA expression, suggesting a possible role in producing protective oxylipins in stressed cells. The results provide mechanistic insights and support for the purported benefits of Vasaka tea in treating lung inflammatory conditions, raising the possibility of further development as a preventative and/or restorative therapy.
Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid
Authors: Ratti Alessandro , Fassi Enrico M. A. , Forlani Fabio , Mori Matteo , Villa Federica , Cappitelli Francesca , Sgrignani Jacopo , Roda Gabriella , Cavalli Andrea , Villa Stefania , Grazioso Giovanni
Published: June 2023

Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in fighting bacterial pathogens. Ellagic acid (EA) is a natural polyphenol that has shown attractive antibiofilm properties. However, its precise antibiofilm mode of action remains unknown. Experimental evidence links the NADH:quinone oxidoreductase enzyme WrbA to biofilm formation, stress response, and pathogen virulence. Moreover, WrbA has demonstrated interactions with antibiofilm molecules, suggesting its role in redox and biofilm modulation. This work aims to provide mechanistic insights into the antibiofilm mode of action of EA utilizing computational studies, biophysical measurements, enzyme inhibition studies on WrbA, and biofilm and reactive oxygen species assays exploiting a WrbA-deprived mutant strain of Escherichia coli. Our research efforts led us to propose that the antibiofilm mode of action of EA stems from its ability to perturb the bacterial redox homeostasis driven by WrbA. These findings shed new light on the antibiofilm properties of EA and could lead to the development of more effective treatments for biofilm-related infections.