bluuebunny/crossref_metadata_2025 huggingface dataset:
KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma
Authors: Gulay Kevin Christian M. , Aoshima Keisuke , Shibata Yuki , Yasui Hironobu , Yan Qin , Kobayashi Atsushi , Kimura Takashi
Published: November 2020

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer; however, their roles in endothelial cell cancers such as canine hemangiosarcoma (HSA) have not been studied. In this study, we found that lysine-specific demethylase 2B (Kdm2b) was highly expressed in HSA cell lines compared to normal canine endothelial cells. Silencing of Kdm2b in HSA cells resulted to increased cell deathin vitrocompared to the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA damage. Similarly, doxycycline-induced Kdm2b silencing in tumor xenografts resulted to decreased tumor sizes compared to the scramble control. Furthermore, Kdm2b was also highly expressed in clinical cases of HSA, and its expression levels was higher than in hemangioma, a benign counterpart of HSA. Based on these results, we hypothesized that pharmacological Kdm2b inhibition can also induce HSA cell death and can be used as an alternative treatment for HSA. We treated HSA cells with GSK-J4, a histone demethylase inhibitor, and found that GSK-J4 treatment also induced apoptosis and cell death. On top of that, GSK-J4 treatment in HSA tumor-bearing mice decreased tumor sizes without any obvious side-effects. In this study, we demonstrated that Kdm2b acts as an oncogene in HSA by enhancing DNA damage response and can be used as a biomarker to differentiate HSA from hemangioma. Moreover, we indicated that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.
Accounting comparability, financial reporting quality and audit opinions: evidence from Iran
Authors: Golmohammadi Shuraki Mojtaba , Pourheidari Omid , Azizkhani Masoud
Published: November 2020

Purpose

Type of audit opinion is important for all stakeholders. Firm-specific characteristics have a direct impact on the type of audit opinion. The purpose of this study is to examine the association between accounting comparability (as a micro level characteristic), financial reporting quality (as a macro level characteristic) and audit opinions.

Design/methodology/approach

This study uses a multivariate regression analysis to tests it hypotheses to a sample of firms listed in Tehran Stock Exchange during 2015–2019. To measure accounting comparability, the authors use De Franco et al. (2011) model, and Hutton et al. (2009) model to measure financial reporting quality. The authors use type of audit opinion, and auditor's remarks (explanatory notes) as the measure for audit opinions.

Findings

The authors find a negative association between accounting comparability, and the proxies for audit opinion. The authors also find that a negative association between financial reporting quality and audit opinions. These results suggest that higher accounting comparability, and higher financial reporting quality (proxied by earnings quality) increases auditor tendency to issue unmodified audit opinion.

Originality/value

To the authors' best knowledge, this is the first study that empirically examines the association between accounting comparability, financial reporting quality and audit opinion. This study provides empirical support for the theoretical views on the association between financial reporting quality and audit opinion. The results could be of interest of both auditors and managers, especially in emerging capital markets, who seek to improve financial reporting quality.
Radio Mirchi: Marketing Strategy for the Bangalore Market
Authors: Jaiswal Anand Kumar , Palan Harit , Panday Prashant , Srinath Nandan , Sen Tapas , Shenoy Srinivasa
Published: November 2020

The case describes how Radio Mirchi dealt with competition in the Bangalore FM radio market. Radio Mirchi's market share in Bangalore started declining within a few months of its successful launch, following the entry of new competitors in the market. The case discusses strategies adopted by the company to regain its market share and become the market leader. It describes the initial product offering of the channel, why it felt the need to redesign its product mix, and eventually how the company changed its product offering. The focus of the case is on the dilemma faced by the organization while shifting to a new product and service design in the face of emerging competition. The case highlights the importance of continuously monitoring the market environment and developing a keen understanding of the consumers' behaviour for an organization to gain and sustain its leadership position in the marketplace.
The Tale of Two Professors
Authors: Sharma Dheeraj , Chandwani Rajesh
Published: November 2020

The case describes an impasse that arose when two professors from diverse backgrounds were co-teaching a course in IMC-M, a reputed business school. Professor Agrawal, who has been educated in the western context, is more research oriented. Prof Yadav, on the other hand has rich industry experience and is an alumni of IMC-M. The case highlights the coordination issues and conflict that occur when there is a lack of communication between two faculties, who had considerable differences in attitudes, beliefs, and expectations. The case illustrates how a conflict unfolds and that effective management of conflict should begin with the design of task itself. The case emphasizes that the important determinants of conflicts are lack of communication and improper management of expectations of the key stakeholders.
Performance Management at IRD Corporation (A)
Authors: Gupta Vishal
Published: November 2020

The Performance Management at IRD Corporation case series is designed to be an in-depth study of performance appraisal in the R&D context. The case series can be used as a platform for discussing the rationale of performance appraisal system, system design and implementation, the differences between R&D and other work contexts (manufacturing, services, etc.), and the challenges involved in R&D management. This case revolves around the Chairman of IRD Corp and his dilemmas, providing an insight to the participants into the challenges of performance management and also R&D management. The series highlights the complex dilemmas associated with managing performance and the necessity of having a new performance evaluation system.
ACC Limited: Project 30-30
Authors: Mukherjee Saral , Raghuram G , Soman Chetan
Published: November 2020

ACC Limited, under Project 30-30, had targeted to produce and sell 30 million tons (mt) of cement in the year 2011. In May 2011, the Head of Central Logistics had found the target of the project to have become increasingly difficult to achieve. He believed that to sell 30 mt of cement, 30 mt had to be transported, thereby, advancing the role of the logistics function from that of a mere facilitator to a critical actor. As possible opportunities to increase sales, issues at the Bulk Cement Corporation (India) Limited (BCCI), and the plant at Wadi are being discussed in the case. The head of BCCI had raised concerns about the decreased logistical capacity of BCCI post a mandate from the Indian Railways on transporting 58-wagon rakes against 41-wagon rakes. A common belief was that with more wagons per rake, the quantity transited from Wadi would be higher. However, this was not the case and a capacity addition was being proposed. The President of Wadi Cluster had expressed that as an effort to reduce the transit time between Wadi and BCCI, priority was given to loading for BCCI. Though an improvement was observed with the introduction of 58 wagons per rake, Wadi was facing issues. This had affected Wadi's ability to serve other markets. The focus of the case is on analysing the options being considered by ACC to increase market presence, logistics capacity at BCCI, and the overall throughput at Wadi.
Bukhari Group of Companies
Authors: Damle Shamkant , Roy Debjit
Published: November 2020

Quality management among multiple business units of a large organization is often difficult if each unit is run independently in terms on their quality standards. In this case, participants will discuss how Bukhari Group of Companies should establish a common brand image through standardized quality. Participants should also understand that common brand image for diverse products does not mean identical level of rejection or customer complaints. It should be understood that different markets have different tolerance for product failures. The participants can chalk out the measures the protagonist of the case should be able to take to effectively steer the Bhukari Group to achieve profits and excellence.
Cummins Generator Technologies India Limited: Building India's First Green Factory
Authors: Varkkey Biju , Soman Chetan
Published: November 2020

Cummins Generator Technologies India Limited (CGTIL) was in the process of setting up a world-class factory at Ranjangaon based on “lean” production principles. The project team, however, went a step ahead and married “green” with “lean”. While lean is about taking the system inefficiencies out, the green is about harmony with nature. The case is about CGTIL's journey of deriving synergies between seemingly conflicting objectives of lean and green.
Online Implementation of the RTE Mandate
Authors: Ranganathan Kavitha
Published: November 2020

This case chronicles the events in the life of a security guard who would like to enroll his five-year-old daughter in a private school under the Right to Education Act (RTE). Section 12(1)(c) of the RTE Act mandates that private schools reserve at least 25% of their seats for children from marginalized and economically weaker sections of society. This case can be used for classroom discussion in a course that deals with e-governance, ICT for Development or Technology deployment/digital service delivery in developing countries. It helps students think of an evaluation framework for assessing an e-governance solution for the disadvantaged and use the framework to critically assess the Gujarat government's digital solution for the RTE programme.
A study of Open Access research data repositories developed by BRICS countries
Authors: Misgar Safat Mushtaq , Bhat Ajra , Wani Zahid Ashraf
Published: November 2020

Purpose

In the present era, research data is a concern for researchers, as they are trying to find new ways to communicate their research findings and conclusions to other researchers in order to increase visibility and credibility. BRICS nations are fast emerging economies and contribute significantly in research output. This study makes an effort to analyze and explore the role of BRICS nations towards open access research data repository registered with Registry of Research Data Repositories.

Design/methodology/approach

The data were gathered from re3data repository, and the search was limited to BRICS nations. The data were further analyzed and tabulated as per set parameters, namely, country-wise distribution, types of contents, subject coverage and language diversity.

Findings

The findings depict that in terms of strength, India has the highest number of data repositories, thereby achieved the first rank among BRICS nations, and South Africa has the least number of data repositories, whereas in terms of content type and subject coverage, India again is leading among BRICS nations. The English language is used by repositories as the main language of the interface.

Practical implications

The study helps to understand the development of research data repositories by BRICS nations. The study is further beneficial to researchers, as Registry of Research Data Repository provides a single platform to access repositories from various disciplines. Readily available data saves time, money and efforts of researchers and helps the researcher in completing their research activity in a very short span of time.

Originality/value

The paper has investigated open access data repositories of BRICS nation that has not been attempted earlier. This gives readers comprehensive overview of research data repositories developed in fast emerging economies of the global. The paper can be very helpful for information managers, OA promoters and education and research policy makers to devise plans and policy bearing in mind the evolving research channels in emerging economies.
Why is evacuation so difficult? Sociocultural aspects of landslide disaster in Ponorogo, Indonesia
Authors: Purworini Dian , Hartuti Desi Puji , Purnamasari Dini
Published: November 2020

Purpose

Sociocultural aspects of populations residing in disaster-prone areas have not often been discussed in disaster evacuation studies. Therefore, the main purpose of this paper is to describe the sociocultural factors affecting evacuation decision-making.

Design/methodology/approach

This was an exploratory research study which used in-depth semi-structured interviews to collect the data. Selection of the informants was also fulfilled via the purposive sampling method with regard to specific criteria. The informants consisted of 20 villagers that had faced a disaster and eight staff members of the Regional Board of Disaster Management of the Republic of Indonesia which is Badan Penanggulangan Bencana Daerah (BPBD), Ponorogo, who had managed it. The data analysis was ultimately performed through thematic coding.

Findings

The results of the coding analysis revealed that sociocultural aspects were among the primary reasons for evacuation decisions before disasters. In this paper, sociocultural factors shaping evacuation decision behavior could be a result of norms, roles, language, leadership, rules, habits, jobs, perceptions, family engagement, as well as other behaviors demonstrated by individuals and the community.

Research limitations/implications

This study is not analyzing the role of the social organization or a religious one and also the economic aspect in the evacuation decision-making.

Practical implications

This paper includes implications for the local government and the BPBD Ponorogo to establish an efficient communication strategy persuading villagers to evacuate. In general, formal policies cannot always be implemented in managing disaster; therefore, visible dedication and solidarity of the members are always needed in order to manage evacuation problems.

Originality/value

This paper meets needs for a study delineating sociocultural factors affecting evacuation decisions before disasters strike. Sociocultural theory could also describe real aspects of culture inherent in the daily lives of populations living in disaster-prone areas.
Analysis of effectiveness of wooden floor finishes in some residential buildings in Lagos, Nigeria
Authors: Folorunso Clement Oluwole
Published: November 2020

Purpose

Wood is one of the materials that is used for building construction either as structural member or as finishes from ages past to contemporary generation. It is composed of elongated, hollow spindle shaped cells that are arranged parallel to each other along the trunk of a tree. The resistance to water, chemicals, strength properties, appearance and decay rate is dictated by the fibrous cells. The purpose of this paper was to examine the application and use of wooden floor finish (an extract from wood) in residential buildings in Lagos, Nigeria, with a view to determine its effectiveness.

Design/methodology/approach

The study adopted a dual stage survey approach before the administration of questionnaire on 100 respondents that were selected through purposive sampling after the initial inquiry on the use of the material from 384 randomly selected samples from the entire population.

Findings

The study shows that the material is applied in all interior spaces except bathrooms and toilets. Minimal adoption is also seen in the kitchen area. Users indicate that wooden floor finish requires little maintenance, has low impact on users' health, considered safe-minimal occurrence of home accidents is recorded, has moderate thermal insulation and affordable.

Practical implications

The usage has impact on the environment due to continuous lumbering activities and lack of adequate plan for reforestation. This suggests that its sustainability depends on afforestation programmes. Its poor performance in sound insulation, water and fire resistance requires further attention. The maintenance is relatively easy and affordable.

Originality/value

The author made a new foray into investigating the performance of wooden floor finish due to its resurgence in the area bearing in mind the unseasoned condition of wood in circulation in the area. Previous adoptions were done by a less aggressive generation of well-trained artisans. Best places for its usage within the interior spaces are identified.
The struggle between welfare state models and prevailing healthcare policy in Scandinavian healthcare legislative documents
Authors: Dahlborg Elisabeth , Tengelin Ellinor , Aasen Elin , Strunck Jeanne , Boman Åse , Ottesen Aase Marie , Dahl Berit Misund , Helberget Lindis Kathrine , Lassen Inger
Published: November 2020

Purpose

The paper aims to compare and discuss the findings of discursive constructions of patients in legal texts from the three Scandinavian countries. Since traditional welfare state systems in Scandinavia are being challenged by new governance systems, new questions are being raised about patient positions and agency, carrying with them potential ethical dilemmas for healthcare professionals.

Design/methodology/approach

The methodology of the paper is inspired by critical discourse analysis. Comprehensively analysing the findings of previous discourse studies on how “the patient” is constructed in central policy texts, this study compares the position of the patient in Norway, Sweden and Denmark.

Findings

The paper reveals ideological struggles across the Scandinavian countries, operating at a political level, a legislative level and a healthcare level. It is shown that national governance systems still exert hegemonic power by strongly influencing patients' degree of choice and autonomy. The discursive struggle between welfare state governance and other governance systems in Scandinavia indicates a shift towards a commercial healthcare market although a traditional welfare model is advocated by professionals and researchers.

Research limitations/implications

Because of the specific conditions of Scandinavian healthcare policy, the findings lack generalisability. The research approach should therefore be explored further in additional contexts.

Practical implications

The findings of this study can inform policymakers, professionals and patients of the ideological values underlying seemingly objective shifts in national policy.

Originality/value

A comparative critical discourse analysis can expose patterns in the Scandinavian approaches to patient rights.
Blockchain in education management: present and future applications
Authors: Bhaskar Preeti , Tiwari Chandan Kumar , Joshi Amit
Published: November 2020

Purpose

This paper aims to provide a systematic literature review on blockchain technology in education to offer a detailed understanding of the present scenario in terms of benefits, barriers, present blockchain technology application and future areas where blockchain technology can be implemented in the other fields of education.

Design/methodology/approach

A bibliometric analysis is conducted on for data in the publications, journals, authors and citations were collected, and examined by applying bibliometric measures. The data was collected from SCOPUS database on the topic “Blockchain Technology in Education”. The following research questions guided this systematic literature review (SLR: How blockchain technology has been defined in educational settings? How were the technology examined (i.e. the methodology)? What were the results of using this technology in an education system?

Findings

The study identifies the benefits, barriers and present application of blockchain technology in education. The analysis shows that blockchain technology in education is still a young discipline, but has a lot of potential to benefits the educational sector at large.

Practical implications

This research provides a groundwork for education institutions, the policymakers and researchers to explore other areas where blockchain technology can be implemented, though this research has also suggested some prospective uses of blockchain technology in different functions of an education system, more application can be brought into the education system to exploit the potential of blockchain technology.

Originality/value

The paper discusses the application of blockchain technology in education with the help of bibliometric analysis. This is one of the first known studies to review the blockchain technology by identifying its benefits, barriers, present blockchain technology application. Based on the analysis, future application areas are also identified.
A framework to activate the health and safety regulations in the Egyptian construction industry
Authors: Elsebaei Mostafa Adel , Elnawawy Omar , Othman Ayman Ahmed Ezzat , Badawy Mohammed
Published: November 2020

Purpose

The construction industry is considered one of the most dangerous industries especially in developing countries such as Egypt. Although safety in Egypt is regulated by mainly four pivotal legislations, namely, Law No. 12 (2003) and Ministerial Decrees No. 211, 126 and 134, construction accident records in Egypt are high. Accordingly, this paper aims to develop a framework to activate the health and safety regulations in the Egyptian construction industry.

Design/methodology/approach

To achieve this aim, a research methodology consisting of a literature review and a survey questionnaire was developed to accomplish three objectives. First, a literature review was used to identify the causes of site accidents and strategies adopted in different countries to improve and enforce safety, safety roles of stakeholders. Second, a survey questionnaire was conducted with a representative sample of large- and medium-sized construction firms in Egypt to examine their perception of the causes of site accidents. Finally, a framework was developed to activate the health and safety regulations in the Egyptian construction industry.

Findings

The research identified 16 causes of construction site accidents. These causes were classified into three categories based on the party responsible for the occurrence of site accidents, namely, workers, organization management and government. Results of data analysis showed that “lack of housekeeping” and “lack of governmental inspection for safety” were ranked the highest causes of site accidents in the Egyptian construction industry, whereas “inefficiency of old safety equipment or no safety equipment at all” and “reluctance to input resources for safety” were ranked the least causes.

Originality/value

This research provides valuable information about the nature of the construction industry with a particular focus on site accidents, causes and impacts of construction site accidents. The study highlighted the safety roles of the Egyptian Governmental bodies in Egypt to improve and enforce safety. The research tackled a topic that received scant attention in construction literature especially in the Egypt context. The framework presented in this paper represents a synthesis that is important and adds value to the knowledge in a manner that has not previously occurred in the Egyptian construction industry.
Enhancing supply resilience in the COVID-19 pandemic: a case study on beauty and personal care retailers
Authors: Chowdhury Md. Tarek , Sarkar Aditi , Saha Pronab Kumer , Anik Rakib Hasan
Published: November 2020

Purpose

The COVID-19 pandemic interrupts the supply chain of products around the world. The supply chains of beauty and personal care products in Bangladesh are also heavily interrupted during this pandemic. While these products are perceived as essential by mass people, retailers are struggling to get the supply of the products and maintain a smooth delivery to the people. Considering such facts, the purposes of the study are to identify how the supply of retailers of these products is interrupted and how they can overcome the interruptions to ensure supply resilience.

Design/methodology/approach

A case study method has been used in this study. The data has been collected through interviews from 16 retailers of beauty and personal care products.

Findings

The results show that the supply of retailers of beauty and personal care products is interrupted in several ways. These include product shortage, limited delivery service, interruption of supplier payment, limited credit facility and irregularity in product delivery. To minimize the impacts of the interruptions and enhance supply resilience, retailers can undertake several strategies including intensive interactions and developing cooperation with the distributors and manufacturers, ordering bulk quantity, formulating an adjusted credit ratio and focusing on product availability over brand preference.

Research limitations/implications

The context of this study is limited to the beauty and personal care products of Bangladesh. Further study can be conducted in other countries and also supply chains of other products to enhance the generalizability of the findings of this study.

Practical implications

Supply interruptions are identified, and strategies are suggested to ensure the supply resilience of retailers of beauty and personal care products. If proposed strategies are implemented by retailers of these products, supply interruptions can be minimized.

Originality/value

The study contributes to the knowledge of the retail supply chain during a pandemic. It also contributes to the supply management and resilience of retailers. As the context is a developing country, the study also contributes to the literature on developing countries.
Stock market liquidity, the great lockdown and the COVID-19 global pandemic nexus in MENA countries
Authors: Alaoui Mdaghri Anas , Raghibi Abdessamad , Thanh Cuong Nguyen , Oubdi Lahsen
Published: November 2020

Purpose

The purpose of this paper is to investigate the impact of the global coronavirus (COVID-19) pandemic on stock market liquidity, while taking into account the depth and tightness dimensions.

Design/methodology/approach

The author used a panel data regression on stock market dataset, representing 314 listed firms operating in six Middle East and North African (MENA) countries from February to May 2020.

Findings

The regression results on the overall sample indicate that the liquidity related to the depth measure was positively correlated with the growth in the confirmed number of cases and deaths and stringency index. Moreover, the market depth was positively related to the confirmed cases of COVID-19. The results also indicate that the liquidity of small cap and big cap firms was significantly impacted by the confirmed number of cases, while the stringency index is only significant for the liquidity depth measure. Moreover, the results regarding sectors and country level analysis confirmed that COVID-19 had a significant and negative impact of stock market liquidity.

Research limitations/implications

This paper confirms that the global coronavirus pandemic has decreased the stock market liquidity in terms of both the depth and the tightness dimensions.

Originality/value

While most empirical papers focused on the impact of the COVID-19 global pandemic on stock market returns, this paper investigated liquidity chock at firm level in the MENA region using both tightness and depth dimensions.
Mentor support systems in a doctoral mentoring program
Authors: Geesa Rachel Louise , McConnell Kat R. , Elam Nicholas Patrick , Clark Ellie
Published: November 2020

Purpose

Education doctoral (EdD) students (mentees) typically hold full-time leadership positions in education-related fields while completing their degree. The types of support these scholar-practitioners need is unique because of their focus on balancing full-time work, academic, and personal needs. This study aims to explore mentor support systems for mentees in their first and second year of the EdD program through a group mentoring program, which is designed to provide resources and access to mentors to promote successful degree completion in five years or less.

Design/methodology/approach

Mentors participated in monthly presentations and discussions with mentees throughout the 2018–2019 academic year, which were video recorded. At the end of the academic year, mentors partook in an interview or focus group meeting.

Findings

Themes emerged related to mentors’ focus on the dissertation process; emphasis on outreach for support; discussions and work/life balance; selection of presentation topics; perceptions of networking opportunities with mentees; desire to build stronger connections with mentees; and concerns/opinions about the mentoring format.

Research limitations/implications

The design of a mentoring program for EdD mentees varies throughout the doctorate degree pathway. Mentors support mentees in their doctoral journey through presentations and discussions about relevant topics during their first two years in the doctoral program. Additional studies are needed regarding EdD mentoring programs for students in the third year to the completion of the degree.

Originality/value

Few studies exist related to mentoring programs for scholar-practitioners in EdD programs. Results from this research provide EdD faculty and advisors insights to group mentoring and discussion topics for first and second year EdD students, based on the mentors’ perspectives.
The receptor tyrosine kinase torso regulates ecdysone homeostasis to control developmental timing in Bombyx mori
Authors: Zhang Zhong‐Jie , Liu Xiao‐Jing , Yu Ye , Yang Fang‐Ying , Li Kai
Published: November 2020

Insect growth and development are precisely controlled by hormone homeostasis. The prothoracicotropic hormone (PTTH) receptor, Torso, is a member of the receptor tyrosine kinase family in insects. Activation of Torso by PTTH triggers biosynthesis and release of the steroid hormone in the prothoracic gland (PG). Although numbers of genes functioning in steroid hormone synthesis and metabolism have been identified in insects, the PTTH transduction pathway via its receptor Torso is poorly understood. In the current study, we describe a loss‐of‐function analysis of Torso in the silkworm, Bombyx mori, by targeted gene disruption using the transgenic CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/RNA‐guided Cas9 nucleases) system. Depletion of B. mori Torso (BmTorso) did not eventually affect larval ecdysis and metamorphosis processes. Instead, BmTorso deficiency resulted in significant extension of developing time during larval and pupal stages with increased pupa and cocoon sizes. The ecdysteriod titers in the hemolymph of BmTorso mutants sharpy declined. Transcriptional levels of genes involved in ecdysone biosynthesis and ecdysteroid signaling pathways were significantly reduced in BmTorso‐deficient animals. Additionally, RNA‐Seq analysis revealed that genes involved in the longevity pathway and protein processing in the endoplasmic reticulum pathway were affected after BmTorso deletion. These results indicate that Torso is critical for maintaining steroid hormone homeostasis in insects.
The Club‐based Climate Regime and OECD Negotiations on Restricting Coal‐fired Power Export Finance
Authors: Liao Jessica C.
Published: November 2020

This article examines the origin, process, and outcome of an understudied, but important multilateral climate change negotiation: the OECD negotiation to restrict export finance for coal‐fired power projects. It assesses how the United States – the OECD’s most powerful member – led the negotiations, and how Japan, South Korea, and China – a non‐OECD state – affected the negotiation’s outcome. It shows how internal and external dynamics of the negotiation under the shadow of China’s rising market influence shaped the preferences of Japan and South Korea in such a way that constrained US attempts to build new rules in curbing coal export finance. This research illustrates the collective action problem in an increasingly fragmented global governance landscape driven by transitions in global power. Contrary to critics that have identified China’s participation in multilateral organizations as weakening the global liberal order, this research shows that a ‘club‐based’ approach to this liberal order proved ineffective absent China’s participation.
Video‐assisted thoracoscopic surgery lobectomy might be a feasible alternative for surgically resectable pathological N2 non‐small cell lung cancer patients
Authors: Zhao Jinbo , Li Weimiao , Wang Meng , Liu Lunxu , Fu Xiangning , Li Yin , Xu Lin , Liu Yang , Zhao Heng , Hu Jian , Liu Deruo , Shen Jianfei , Yang Haiying , Li Xiaofei
Published: November 2020

Background

The majority of previous studies of the clinical outcome of video‐assisted thoracoscopic surgery (VATS) versus open lobectomy for pathological N2 non‐small cell lung cancer (pN2 NSCLC) have been single‐center experiences with small patient numbers. The aim of this study was therefore to investigate these procedures but in a large cohort of Chinese patients with pathological N2 NSCLC in real‐world conditions.

Methods

Patients who underwent lobectomy for pN2 NSCLC by either VATS or thoracotomy were retrospectively reviewed from 10 tertiary hospitals between January 2014 and September 2017. Perioperative outcomes and overall survival of the patients were analyzed. Cox regression analysis was performed to identify potential prognostic factors. Propensity‐score analysis was performed to reduce cofounding biases and compare the clinical outcomes between both groups.

Results

Among 2144 pN2 NSCLC, 1244 patients were managed by VATS and 900 by open procedure. A total of 305 (24.5%) and 344 patients died during VATS and the thoracotomy group during a median follow‐up of 16.7 and 15.6 months, respectively. VATS lobectomy patients had better overall survival when compared with those undergoing the open procedure (P < 0.0001). Multivariate COX regression analysis showed VATS lobectomy independently favored overall survival (HR = 0.75, 95% CI: 0.621–0.896, P = 0.0017). Better perioperative outcomes, including less blood loss, shorter drainage time and hospital stay, were also observed in patients undergoing VATS lobectomy (P < 0.05). After propensity‐score matching, 169 patients in each group were analyzed, and no survival difference were found between the two groups. Less blood loss was observed in the VATS group, but there was a longer operation time.

Conclusions

VATS lobectomy might be a feasible alternative to conventional open surgery for resectable pN2 NSCLC.

Key points

Significant findings of the study: VATS lobectomy has comparative OS in pN2 NSCLC versus open procedure in resectable patients.

What this study adds: VATS lobectomy might be feasible for pN2 NSCLC.
Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR‐mutation non‐small cell lung cancer: A phase II single‐arm prospective clinical trial
Authors: Lu Zhi‐qin , Cai Jing , Wang Xia , Wei Jian‐ping , Zeng Zhi‐min , Huang Long , Liu An‐wen
Published: November 2020

Background

Leptomeningeal metastasis (LM) is associated with poor prognosis in non‐small cell lung cancer (NSCLC). The aim of this study was to investigate the efficacy and safety of osimertinib combined with bevacizumab for LM from epidermal growth factor receptor mutation (EGFRm) NSCLC.

Methods

We conducted a phase II single‐arm prospective clinical trial of EGFRm NSCLC with LM treated with osimertinib combined with bevacizumab. LM response assessment was based on the modified RANO LM radiological criteria; CNS and extra‐CNS response was evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. The primary end points included LM progression‐free survival (PFS) and objective response rate (ORR); the secondary end points included safety and LM overall survival (OS).

Results

A total of 14 patients were included in the study, with a median age of 61 years, and they were predominantly female (64%). EGFR mutations were reported in exons 19 del (n = 7) and 21 L858R (n = 7). When LM was diagnosed, 12 (85.7%) patients had clinical symptoms, 71.4% (10/14) of patients were diagnosed with LM by cytology, and five (35.7%) patients had a performance status (PS) score > 2. The median LM PFS was 9.3 months (95% CI: 8.2–10.4), and the LM ORR was 50%. The safety findings in the present study were consistent with the known profile of osimertinib with bevacizumab; the median LM OS was 12.6 months, and the one‐year survival rate was 35.7%.

Conclusions

Osimertinib combined with bevacizumab is an appropriate treatment option for patients with LM from EGFRm NSCLC.

Key points

Significant findings of the study

To date, there is no prospective clinical study on the treatment of osimertinib combined with bevacizumab in EGFRm NSCLC with LM.

What this study adds

The median LM PFS was 9.3 months (95% CI: 8.2–10.4), and the LM ORR was 50%, the median LM OS was 12.6 months, and the one‐year survival rate was 35.7%. Osimertinib combined with bevacizumab is an appropriate treatment option for patients with LM from EGFRm NSCLC.
Risks and Benefits of Initial Coin Offerings: Evidence from impak Finance, a Regulated ICO*
Authors: Boulianne Emilio , Fortin Mélissa
Published: November 2020

This study provides a better understanding of the business and the regulated environment surrounding initial coin offerings (ICOs). An ICO is a call for funding to raise funds through a blockchain, where cryptoassets are issued. Key stakeholders involved are the firms launching ICOs, the investors, and the financial regulators. We conducted a case study of a firm that launched an ICO, impak Finance, the first regulated ICO in Canada. Based on the interviews of key respondents, we developed a framework identifying the main risks and benefits for firms to performing an ICO, showing differences between unregulated and regulated ICOs. Our study makes a number of research and practical contributions. First, we document the case of the first regulated ICO in Canada. The interviews conducted provided access to privileged insider information. Second, very few studies have been conducted on the impact of blockchains as a financing vehicle. ICOs using blockchains may be disruptive not only from a technology standpoint but also from a financial standpoint. While the possible applications of blockchains are unknown to us to date, we do know that blockchains have the potential to challenge the traditional financial system monitored by financial regulators. Last, the study identifies, through a framework, the risks and benefits of performing an ICO in an unregulated versus a regulated context, which has practical implications for firms operating in the fintech space. We trust that this framework will be useful for firms using ICOs, for investors, and for financial regulators.
Effect of Using an Age‐adjusted D‐dimer to Assess for Pulmonary Embolism in Community Emergency Departments
Authors: Ghobadi Ali , Lin Bryan , Musigdilok Visanee V. , Park Stacy J. , Palmer‐Toy Darryl E. , Gould Michael K. , Vinson David R. , Hutchison Dana M. , Sharp Adam L.
Published: November 2020

Background

The objective of this study was to evaluate the effect of changing the laboratory‐reported D‐dimer reference intervals to age‐adjusted reference intervals on the use of advanced chest imaging and 30‐day adverse events among emergency department (ED) encounters.

Methods

A retrospective interrupted time‐series analysis of ED encounters for patients > 50 years evaluated for suspected pulmonary embolism (PE) from April 2014 to April 2016. The primary outcome was use of advanced diagnostic imaging, and the secondary outcome was 30‐day mortality or PE diagnosis. Secondary analyses also quantified delayed PE diagnoses pre‐ and postintervention. A generalized estimating equation segmented logistic regression model, adjusting for patient and facility characteristics, was used to determine changes in odds of diagnostic imaging and 30‐day mortality or PE diagnoses.

Results

A total of 10,534 (5,153 pre‐ and 5,381 postimplementation) ED encounters were included. Advanced imaging was obtained in 35.9% of pre‐ versus 33% of postimplementation encounters. Age‐adjusted D‐dimer (AADD) showed a small and nonsignificant decrease in month‐to‐month trends of advanced chest imaging postimplementation (odds ratio [OR] = 0.98, 95% confidence interval [CI] = 0.96 to 1.00). Use of advanced imaging in patients with D‐dimer values lower than 500 ng/mL fibrinogen‐equivalent units (FEU) was similar in the preintervention (5.8%) and postintervention (6.8%) periods. However, imaging was obtained in 30% of patients postintervention with a D‐dimer result less than AADD reference interval , but more than the historical 500 ng/mL FEU reference interval. Implementing an AADD threshold demonstrated no change in the rate of 30‐day adverse events (missed PE or mortality).

Conclusion

Changing the laboratory‐reported D‐dimer reference intervals for evaluation of PE was not associated with reduction in advanced chest imaging and did not increase 30‐day adverse events. However, there was substantial noncompliance with the age‐adjusted reference intervals in the postintervention period likely blunting the impact of this intervention.
Social media reveals consistently disproportionate tourism pressure on a threatened marine vertebrate
Authors: Papafitsoros K. , Panagopoulou A. , Schofield G.
Published: November 2020

Establishing how wildlife viewing pressure is distributed across individual animals within a population can inform the management of this activity, and ensure targeted individuals or groups are sufficiently protected. Here, we used social media data to quantify whether tourism pressure varies in a loggerhead sea turtle Caretta caretta population and elucidate the potential implications. Laganas Bay (Zakynthos, Greece) supports both breeding (migratory, and hence transient) and foraging (resident) turtles, with turtle viewing representing a major component of the tourism industry. Social media entries spanning two seasons (April to November, 2018 and 2019) were evaluated, and turtles were identified via photo‐identification. For the 2 years, 1684 and 2105 entries of 139 and 122 unique turtles were obtained from viewings, respectively (boats and underwater combined). However, while residents represented less than one‐third of uniquely identified turtles, they represented 81.9 and 87.9% of all entries. Even when the seasonal breeding population was present (May to July), residents represented more than 60% of entries. Notably, the same small number of residents (<10), mostly males, were consistently viewed in both years; however, different individuals were targeted by boats versus underwater. Thus, turtles appear to remain in the area despite high viewing intensity, possibly indicating low disturbance. However, photo‐identification records revealed a high risk of propeller and boat strike to residents (30%) leading to trauma and mortality. To reduce this threat, we recommend the compulsory use of propeller guards for all boats, compliance with speed regulations and the creation of temporary ‘refuge’ zones for resident animals at viewing hotspots, with these suggestions likely being relevant for other wildlife with similar population dynamics. In conclusion, social media represents a useful tool for monitoring individuals at a population scale, evaluating the pressure under which they are placed, and providing sufficient data to refine wildlife viewing guidelines and/or zoning.
Impact of policy changes on the provision of naloxone by pharmacies in Ontario, Canada: a population‐based time–series analysis
Authors: Antoniou Tony , Martins Diana , Campbell Tonya , Tadrous Mina , Munro Charlotte , Leece Pamela , Mamdani Muhammad , Juurlink David N. , Gomes Tara
Published: November 2020

Background and aims

In June 2016, the Ontario, Canada government implemented the Ontario Naloxone Program for Pharmacies (ONPP), authorizing pharmacists to provide injectable naloxone kits at no charge to all Ontario residents. In March 2018, the program was amended to include intranasal naloxone and remove the requirement to present a government health card to the dispensing pharmacist. We examined whether these changes increased naloxone dispensing through the ONPP.

Design

Population‐based time–series analysis using interventional autoregressive integrated moving average models.

Setting

Ontario, Canada.

Participants

All Ontario residents between 1 July 2016 and 31 March 2020.

Measurements

Monthly rates of pharmacy naloxone dispensing.

Findings

Overall, 199 484 individuals were dispensed a naloxone kit during the study period. In the main analysis, the rate of pharmacy naloxone dispensing increased by 65.1% following program changes (55.6–91.8 kits per 100 000 population between February 2018 and May 2018; P = 0.01). In subgroup analyses, naloxone dispensing increased among individuals receiving opioid agonist therapy (OAT) (3374.9–7264.2 kits per 100 000 OAT recipients; P = 0.04) among individuals receiving other prescription opioids (192.8–381.8 kits per 100 000 population prescribed opioids; P < 0.01), among individuals with past opioid exposure (134.7–205.6 kits per 100 000 population with past opioid exposure; P < 0.01) and in urban centers (56.2–91.4 kits per 100 000 population; P < 0.01). We did not observe a clear impact on pharmacy‐dispensed naloxone to individuals with no or unknown opioid exposure (34.4–39.3 kits per 100 000 population with no/unknown opioid exposure; P = 0.42) and in rural regions (50.4–97.2 kits per 100 000 population; P = 0.09).

Conclusions

Changes to the Ontario Naloxone Program for Pharmacies to add intranasal naloxone and remove the requirement to present a government health card appeared to increase pharmacy‐based naloxone dispensing uptake in Ontario, Canada, particularly among individuals at high risk of inadvertent opioid overdose.
Phenotype and biological characteristics of endometrial mesenchymal stem/stromal cells: A comparison between intrauterine adhesion patients and healthy women
Authors: Min Jiali , Lu Na , Huang Shengjian , Chai Xiahua , Wang Susu , Peng Lin , Wang Jian
Published: November 2020

Problem

Intrauterine adhesion (IUA) is a uterine disorder with partial or total obstruction of the uterine cavity and/or the cervical canal primarily caused by intrauterine operations and infections. It is the most common cause of uterine infertility and recurrent abortion. However, the reasons for endometrium repair disorders in patients with IUA are still unclear. While increasing evidence demonstrates that endometrial mesenchymal stem/stromal cells (EMSCs) contribute to the regeneration and repair of endometrium, the roles of EMSCs in the pathogenesis of IUA have not been reported.

Methods and study

We investigated the differences of phenotype and biological characteristics between EMSCs from women with IUA and healthy women. Firstly, the fibrosis of endometrium were measured by immunohistochemistry and Masson staining. Second, we used immunofluorescence to detect the location of EMSCs in endometrial tissue, and the proportion of CD146+CD140b+ in the two groups was compared by flow cytometry. Then, plate colony formation experiment, CCK‐8 assay, flow cytometry, would‐healing assay, and transwell invasion experiment were used to compare the cloning ability, proliferation, cell cycle, migration and invasion capabilities respectively. Finally, we compared the potential angiogenesis and immunosuppression capabilities.

Results

Our results showed that there were fewer CD146+CD140b+ cells in patients with IUA, and the clone‐forming, migration, invasion, angiogenic and immunosuppressive abilities of the EMSCs of patients with IUA were significantly decreased compared with those of healthy women.

Conclusion

There are some differences between the EMSCs of IUA patients and healthy women, which may be related to the occurrence of IUA and dysfunction of endometrium.