bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Ischemic Stroke in Moyamoya Disease: A Case Report
Authors: Kustila Ela
Published: July 2024

Introduction: Moyamoya disease (MMD) is also known as spontaneous occlusion of the circle of Willis, is a chronic, occlusive cerebrovascular disease with an unknown etiology.1 It is characterized by progressive stenosis or occlusions of the intracranial internal carotid artery (IAC) and or the proximal portion of the anterior cerebral artery (ACA) and middle cerebri artery (MCA).1,2 This steno-occlusive pattern is associated with a compensatory development of a collateral network of vessels at the base of the brain, appearing as a “puff of smoke” on conventional angiography ( “moyamoya” in Japanese).1,2 The clinical  presentations of MMD include transient ischemic attacks, ischemic strokes, hemorrhagic strokes, seizure, headache, and cognitive impairment.1,2,3
Case Report: This case study presents a 48-year-old male with symptoms hemiparesis sinistra. Brain CT scan result was subacute infarct at right anterior cerebri artery territory. Digital Substract Angiography (DSA) result was occlusion in the right media cerebri artery (MCA) and right anterior cerebri artery (ACA), severe stenosis right verterbral artery until basilar artery, moyamoya vessels at anterior and posterior circulation.
Explorando la riqueza biológica de Sinaloa: los anfibios y reptiles de la reserva “El Mineral de Nuestra Señora de la Candelaria”
Authors: Jacobo-González José David , Pérez-Delgadillo Ana Gisel , Chan-Chon Diego Sidu , Leal-Sandoval Alfredo , Lara-Reséndiz Rafael A.
Published: July 2024

The study on the biological richness of the “El Mineral de Nuestra Señora de la Candelaria” reserve in Sinaloa reveals its outstanding diversity of amphibians and reptiles, as well as the importance of their conservation. Over the years, this reserve, located in Cosalá, has served as a refuge for numerous endemic and protected species, facing challenges such as poaching, habitat degradation, forest fires and complex social problems. Despite these challenges, conservation actions such as environmental education and surveillance have helped mitigate negative impacts. This study highlights the prevailing need to preserve these unique ecosystems to maintain ecological balance, protect the diversity of herpetofauna in the Sierra Madre Occidental and enjoy its ecosystem services, providing a solid foundation for future long-term ecological management and conservation strategies.
Inventario de la Herpetofauna de México 2023
Authors: Balderas-Valdivia Carlos Jesús , González-Hernández Adriana
Published: July 2024

For the Inventory of the Herpetofauna of Mexico, a total of 1,422 native herpetofaunal species are reported so far (892 endemic, 62.7%), of which 430 (30.2%) are amphibians (15 families and 58 genera) with 299 (69.5%) endemic species, and 992 (69.8%) reptiles (41 families and 154 genera) with 593 (59.8%) endemic species.
Perbandingan Lama Adaptasi Lensa Bifokal Dan Progressive Addition Lens (Pals) Terhadap Kenyamanan Pasien Di Optik Kota Padang
Authors: Ermi Yusfita
Published: July 2024

This paper discusses the comparison of the length of adaptation  bifocal lenses and Progressive Addition Lenses  (PALs) to patient comfort in optics Pariaman City. This study aims to reveal: (1) The effect of the use  bifocal lenses and PALs on patient comfort in the optics Pariaman City, (2) The process of adaptating bifocal lenses and PALs to the comfort of activities patients  in optics Pariaman City. The type of research used is a quantitative descriptive approach. The population in this study were presby

 

Contents lists available at Journal ARO YLPTK Padang
Journal of Optometry, Health and Education Research
ISSN: XXXX-XXXX (Print)ISSN: XXXX-XXXX(Electronic)
 
Journal homepage: https://jurnal-aropadang.org/index.php/jophr/index  

 

 
opia patients who used bifocal lens glasses and PALs. Sampling using the Slovin formula. Data were collected through questionnaires and research instruments using a check list. The results of the research of respondents in the optics Pariaman City were 53 respondents including 18 respondents who wore bifocal lenses and 35 respondents who wore PALs. Respondents who felt the effect of using bifocal lenses and PALs in the optics of Kota Pariaman were 0 respondents (0%) and those who did not feel the effect of using bifocal lenses were 18 respondents (100%) and PALs were 35 respondents (100%). While the respondents who felt the process of adapting the use of bifocal lenses in the optics Pariaman City were 18 respondents (100%) and PALs were 35 respondents (100%) and 0 respondents (0%) did not feel the process of adaptation to the use of bifocal lenses and PALs. Based on the results of this study, there are several suggestions, namely: (1) It is recommended for researchers and RO to learn more material about lenses and lens adaptation process, (2) It is hoped the academy will add books reference sources about lenses and lens adaptation processes, (3) It is hoped that the public will ask the RO for education about lenses and lens adaptation before buying glasses.
PEMBELAJARAN KONSEP DIRI UNTUK MENUMBUHKAN KETERAMPILAN SOSIAL ANAK USIA DINI
Authors: Oktavia Yuki
Published: July 2024

Abstract
Tujuan dari penelitian ini adalah untuk mengetahui bagaimana konsep diri dalam membantu perkembangan atau keterampilan sosial pada anak usia dini. Metode yang digunakan dalam penelitian ini adalah kajian pustaka. Setelah data dikumpulkan dari beberapa sumber, kemudian diolah dan disimpulkan. Hasil penelitian adalah bahwa Konsep diri merupakan  hasil dari proses belajar manusia melalui hubungannya dengan orang lain dan Lingkungan memiliki peran yang penting dalam proses mengenal diri terutama dalam pengalaman relasi dengan orang lain dan bagaimana orang lain memperlakukan dirinya yang akan membentuk keterampilan sosial pada anak sejak dini, konsep diri tersebut merupakan hal yang paling penting untuk menjalin hubungan yang seimbang dengan sebayanya. Hubungan pertemanan yang seimbang dapat diperoleh jika anak memiliki rasa percaya diri dan bisa menghadapi berbagai masalah serta mencari solusinya. Keterampilan sosial juga membuatnya mudah diterima oleh anak lain karena mampu berperilaku sesuai harapan lingkungannya secara tepat.
Kata Kunci :konsep diri,keterampilan sosial
Meningkatkan Perkembangan Sosial Emosional Anak Usia Dini Melalui Kegiatan Mengantri Pada Anak Kelompok A Di KB Al Mubtadiin Telaga
Authors: Najiah Ani , Yulia Khoerunnisa Eka , Silitonga Mirdat
Published: July 2024

Permasalahan dalam penelitian ini adalah belum berkembangnya perkembangan sosial emosional anak pada kegiatan mengantri. Tujuan dalam penelitian ini untuk mengetahui peningkatan perkembangan sosial emosional anak usia dini melalui kegiatan mengantri pada anak kelompok A di KB Al Mubtadiin Telaga. Metode penelitian yang digunakan ialah penilitian tindakan kelas. Analisis data dalam penelitian ini untuk menganalisis hasil refleksi, lembar observasi, APKG dengan mengamati simulasi pembelajaran untuk melihat kesesuaian aspek yang di amati serta kesesuaian guru dalam mengajar. Subjek dalam penelitian ini adalah kepala sekolah, supervisor  dan teman sejawat, dan 21 murid kelompok A di KB Al Mubtadiin Telaga. Kelompok A dipilih karena kemampuan anak yang belum berkembang dan lebih mudah diamati. Hasil penelitian menunjukan pencapaian  peningkatan pada siklus I sebanyak 65,2%  dan di siklus II sebanyak 85,2% dimana dalam  kegiatan tersebut anak sudah dapat disiplin dan perkembangan sosial emosional anak di KB Al Mubtadiin Telaga sudah berkembang dengan maksimal. Sehingga dapat disimpulkan bahwa dengan menerapkan kegiatan mengantri ini dapat meningkatkan perkembangan sosial emosional anak.
Memaknai Secara Teologis tentang Garam Dunia Matius 5:13
Authors: Trisnaningtyas Vendyah , Nugroho Eko , Sembiring Lena Anjarsari
Published: July 2024

Abstract: Jesus' words about the Salt of the world in Matthew 5:13 are a meaningful expression, so to understand them cannot be through literal or literal knowledge. In this article, the author uses a descriptive method, namely with a literature approach by collecting data and analyzing Matthew 5:13. Through the case of how as a salt generation in Christianity and everyday life and in ministry. Based on this research, it is concluded that the meaning of salt not only refers to the inherent identity of followers of Jesus Christ wherever they go and wherever they are. But it's more about how to be a part of and create a salt generation in the Christian life.Abstrak: Perkataan Yesus tentang Garam dunia dalam Injil Matius 5:13 merupakan suatu ungkapan bermakna, sehingga untuk memahaminya tidak boleh melalui pengetahuan secara harafiah atau literal. Dalam artikel ini penulis menggunakan metode deskriptif yaitu dengan pendekatan literatur dengan mengumpulkan data-data dan menganalisis Matius 5:13. Melalui kasus bagaimana sebagai salt generation dalam kekristenan dan kehidupan sehari-hari serta dalam pelayanan. Berdasarkan penelitian ini disimpulkan bahwa makna garam bukan saja menunjuk kepada identitas pengikut Yesus Kristus yang melekat kemanapun mereka pergi dan dimanapun mereka berada. Akan tetapi lebih kepada bagaimana menjadi bagian dan mewujudkan salt generation dalam kehidupan kekristenan.
Eksplorasi Perumpamaan Dirham yang Hilang
Authors: Sarmauli Sarmauli , Lana Isa Andreyanku
Published: July 2024

Abstract: This research is motivated by the author's curiosity to explore the contemporary meaning of the content of the parable of the prodigal son in Luke 15:8-10, which has become a topic of discussion in Christianity. This parable illustrates God's love for a lost soul and conveys moral and spiritual messages that are relevant in the context of modern Christian life. The purpose of this research is to explore the meaning of the parable of the lost dirham in the Gospel of Luke in the controversy or phenomenon of contemporary Christianity. The research method in this paper uses a qualitative approach through literature review to explore the moral and spiritual messages contained in this parable and its relevance in contemporary Christian religious education. The findings confirm that the parable emphasizes the infinite love of the Creator for each individual who feels "lost" in his or her journey. More than just a story, the parable reflects God's love and concern for the "lost" soul. Its moral and spiritual message is a strong foundation in modern Christian religious education, encouraging us to appreciate the uniqueness of each soul while spreading the message of love and hope to others.
Abstrak: Penelitian ini dilatarbelakangi oleh keingintahuan penulis untuk menggali makna terkini dalam muatan perumpamaan tentang 'Dirham yang Hilang' dalam kitab Lukas 15:8-10 menjadi pokok perbincangan dalam ajaran agama Kristen. Perumpamaan ini mengilustrasikan kasih Ilahi terhadap jiwa yang terhilang, serta menyampaikan pesan moral dan spiritual yang relevan dalam konteks kehidupan Kristen modern. Tujuan penelitian ini berupaya untuk menggali makna kembali pada perumpamaan dirham yang hilang dalam kitab Injil Lukas dalam kontestasi ataupun fenomena Kekrisnan saat ini. Metode penelitian dalam tulisan ini menggunakan pendekatan kualitatif melalui telaah literatur untuk mengeksplorasi pesan moral dan rohani yang terkandung dalam perumpamaan ini dan relevansinya dalam pendidikan agama Kristen masa kini. Hasil temuan menegaskan bahwa perumpamaan ini menyoroti kasih yang tak terbatas dari Sang Pencipta terhadap setiap individu yang merasa 'terhilang' dalam perjalanannya. Lebih daripada sekadar kisah, perumpamaan ini menjadi cermin kasih dan perhatian Ilahi terhadap jiwa yang 'terhilang'. Pesan moral dan spiritualnya menjadi fondasi kuat dalam pendidikan agama Kristen modern, mendorong kita untuk menghargai keunikan setiap jiwa sambil menyebarkan pesan kasih dan harapan kepada sesama.
Implementasi Kuasa Kasih Kristus berdasarkan Roma 8:35-39 bagi Orang Percaya Masa Kini
Authors: Setiawan Iwan , Samuel  , Hutabarat Ruth Fulcher , Bitriyani Novillia Dian , Agustiani Ni Made Tirza
Published: July 2024

Abstract: God's love is the highest and most noble than anything else. God's love for sinners is expressed through His Son who became the savior to die for sins as an intermediary for sinners to God. There are many people who do not realize how great the power of God's love is in their lives because of the various things they have experienced, so they live in fear, doubt, and disbelief due to the suffering they have experienced. The research method used is descriptive, namely a method used in researching the status of human groups, objects, research conditions, systems of thought or a class of events in the present which aims to create good and systematic, factual descriptions, images or paintings. The hermeneutic method means expressing, translating, interpreting. The hermeneutic source material is Romans 8: 35-39 with the aim of achieving an understanding of the meaning. The research results obtained are that nothing can separate from the power of Christ's love, the power of Christ's love makes believers more than winners, the power of Christ's love is above all. So that the implementation of the power of Christ's love is based on the belief that nothing will separate believers from the Love of God that is in Christ Jesus, this makes believers selfless, generous and kind, because Christ's love is so great that they have confidence. to be able to share it with others.
Abstrak: Kasih Allah yang paling tinggi dan paling mulia dibanding apapun. Kasih Allah kepada orang-orang berdosa dinyatakan melalui AnakNya yang menjadi juruselamat untuk mati menebus dosa menjadi perantara orang berdosa kepada Allah. Ada banyak orang yang tidak menyadari betapa besar kuasa kasih Allah dalam hidupnya karena berbagai hal yang dialaminya sehingga mereka hidup dalam ketakutan, keraguan, ketidakpercayaan akibat penderitaan yang dialami. Metode penelitian yang digunakan adalah deskriptif yaitu suatu metode yang digunakan dalam meneliti status kelompok manusia, objek, riset kondisi, sistem pemikiran atau suatu kelas peristiwa pada masa sekarang yang bertujuan untuk membuat deskripsi, gambaran atau lukisan secara baik dan sistematis, factual. Metode hermeneutika berarti mengekspresikan, menerjemahkan, menafsirkan. Bahan sumber hermeneutikanya adalah Roma 8: 35-39 dengan tujuan untuk mencapai pemahaman makna. Hasil penelitian yang diperoleh adalah tidak ada yang dapat memisahkan dari kuasa kasih Kristus, kuasa kasih kristus menjadikan orang percaya lebih dari pemenang, kuasa kasih kristus di atas segalanya. Sehingga implementasinya kuasa kasih Kristus didasari oleh keyakinan bahwa tidak akan ada yang memisahkan orang percaya dari Kasih Allah yang ada dalam Kristus Yesus, hal itu membuat orang percaya tidak mementingkan diri sendiri, menjadi murah hati dan baik hati, karena begitu besarnya kasih Kristus sehingga memiliki keyakinan untuk dapat membagikannya kepada orang lain.
Back to Basics: Considering Categories of Data Services Consults
Authors: Wink Isaac
Published: July 2024

Consultations are fundamental to data librarianship, serving as a vital means of one-on-one support for researchers. However, the topics and forms of support unique to data services consults are not always carefully considered. This commentary addresses five common services offered by data librarians—dataset reference, data management support, data analysis and software support, data curation, and data management (and sharing) plan writing—and considers strategies for successful patron support within the boundaries of a consultation.
Ciencia en un museo arqueológico: análisis emocional de una experiencia interdisciplinar en la formación docente
Authors: Hernández Míriam , Merchán García María José , Corrales Serrano Mario , Corbacho Cuello Isaac
Published: July 2024

La compartimentalización de las diversas áreas de conocimiento en la formación de docentes provoca, a menudo, un efecto de desmotivación que les genera emociones poco favorables para su aprendizaje. Un abordaje interdisciplinar de las didácticas de varias áreas puede favorecer el interés y mejorar variables afectivas como emociones, autoeficacia y actitudes relacionadas con el futuro desempeño docente. En este artículo se presenta el análisis emocional de una experiencia interdisciplinar llevada a cabo con estudiantes de 2º curso del Grado en Educación Primaria, consistente en la visita didáctica a un museo arqueológico y la realización de actividades científicas con la historia como pretexto. Los y las docentes en formación inicial manifiestan sentir emociones positivas y activadoras, destacando curiosidad y sorpresa mientras que las emociones negativas apenas aparecen. Se han explorado las diferencias afectivas según el género y el bachillerato de procedencia. Se encuentran correlaciones entre las emociones y el aprendizaje, la motivación y la didáctica.
Ver, leer y decir. Observar clases de historia para la investigación y la formación docente
Authors: González María Paula
Published: July 2024

Este escrito integra un conjunto de reflexiones sobre nuestra práctica de investigación en enseñanza de la historia con una serie de evidencias de una indagación sobre prácticas docentes en relación con la historia argentina reciente, con especial foco a lo que los docentes producen y recrean en las aulas. Se alude en particular a la realización de observaciones de clases en secundaria subrayando la potencialidad de las exposiciones dialogadas. En conjunto, se aboga por la retroalimentación entre investigación y formación del profesorado.
Pour une poétique de l’extra-vocalité : le rapport aux cris dans la musique contemporaine
Authors: Albert Castanet Pierre
Published: July 2024

Résumé. L’art sonore favorisant le médium de la voix tient à la fois du naturel et du paradoxal. A partir de ce constat, en dehors des attributs du simple langage quotidien, le matériau vocal de la musique contemporaine est allé jusqu’à intégrer le domaine pluriel du cri. De Russolo à Milhaud, de Berio à Globokar, de Xenakis à Dao… le cri – à teneur figuraliste ou pas – a alors pu passer de l’élément acoustique basique à une expression pertinente d’ordre cathartique…
Análisis de la imagen sonora en la interpretación musical
Authors: Tomás García Fabiola
Published: July 2024

Resumen. El concepto de imagen sonora es fundamental en la interpretación musical, ya que se trata de la representación mental del sonido que el intérprete crea antes de producirlo físicamente. Esta imagen, influenciada por la partitura y la experiencia del músico, es crucial para dar vida a la música y guiar la interpretación. Pedagogos como W. Bardas o G. P. Prokofiev destacan su importancia para el desarrollo técnico y expresivo del intérprete, así como para la coordinación motriz. Un amplio número de pedagogos y teóricos musicales han explorado este concepto, denominándolo de diversas maneras, como imagen estética o mental, y destacando su función en la planificación de movimientos corporales y en la expresividad musical.
El trabajo en la imagen sonora también influye positivamente en la lectura a primera vista y en la capacidad de improvisación del intérprete. Por último, abordar este aspecto contribuye de manera significativa a la calidad y belleza del sonido producido por el intérprete. Por todas estas razones, es esencial fomentar una imagen sonora clara y precisa desde las primeras etapas de aprendizaje.
Making Music and Politics in Puerto Rico: Performative Praxis and Subjectivation in Musical Activism
Authors: Espada-Brignoni Teófilo
Published: July 2024

Abstract. Musicians have played important roles in social movements and different forms of political action. As a social, cultural, and psychological phenomenon, the relationships between music, musicians, and politics are embedded in singular processes that warrant studying how musicians engage in political actions and make sense of their musical performances and roles in activism. In this article I describe and analyze the experience of six musicians related to their performances supporting activists and social movements. I conducted six semi-structured interviews through phone calls and video conferencing and analyzed the transcripts by focusing on the forms of subjectivations they described when remembering their interactions with activists and organizers. My main focus is how these musicians used music to support protests, fostered a sense of collective identity, and coordinated their music with activists and organizers.
La décentralisation des institutions culturelles et la démocratisation de l’accès à la culture (en France, depuis 1959)
Authors: Aubrée Aurélie
Published: July 2024

Résumé. A la fin des années 1950, le gouvernement français a désiré rendre accessible les œuvres capitales de l’humanité au plus grand nombre, assurer la plus vaste audience du patrimoine culturel et favoriser la création de l’art… C’est le début de la décentralisation des institutions culturelles et de la démocratisation de l’accès à la culture. A coup de textes législatifs marquants, l’opération va toucher autant les musées que l’enseignement artistique (charte de l’éducation nationale).
Castelar novelista y sus músicas
Authors: Gallego Gallego Antonio
Published: July 2024

Resumen. La presencia de Emilio Castelar en la la Real Academia de Bellas Artes de San Fernando es objeto de estudio en este artículo. Su amor a la música fue tan intenso que, en todos sus escritos, las imágenes musicales afloran en sus páginas con muchísima abundancia.
L'aspetto numerico e le regole proporzionali tra visibile e udibile (focus sul numero sei)
Authors: Longo Anna Laura
Published: July 2024

Resumen. L'articolo invita all'ascolto di brani musicali soprattutto pianistici, creando connessioni con altri linguaggi (pittura e architettura). Viene dato un risalto all'aspetto numerico. In particolare viene ad essere sviluppato un focus sul numero sei. L'interdisciplinarità è vista a tutti gli effetti come una risorsa per la conoscenza.
Changing Russian Presidential Discourse on the example of Putin's inaugural speeches: results of quantitative content analysis
Authors: Voronin Vsevolod Alekseevich , Voronov Aleksei Vital'evich
Published: July 2024

This article examines V. V. Putin's discourse from the point of view of its semantic content – the values voiced by the president, a view on the further development of the country, setting goals, etc. The object of the study is the inaugural speeches of the President of Russia, and the subject is the narrative aspect of these speeches. The article hypothesizes that the semantic accents in the inaugural speeches of the head of state changed in accordance with the domestic and foreign policy situation and in later speeches became more focused on foreign policy problems, as well as had a more conservative orientation. The purpose of the work is to identify changes in the narrative aspect of Vladimir Putin's inaugural speeches and evaluate them in the context of changes in the political situation in the country and the world. During the research, methods such as quantitative content analysis (performed separately for each text), comparative analysis, and graphical modeling were used. The authors concluded that over time, the presidential discourse considered on the example of inaugural speeches has undergone significant semantic changes. The share of values characteristic of conservative ideology has become higher in later speeches. At the same time, the presence of liberal democratic narratives in recent speeches has been minimal. The President's speeches have become more focused on global foreign policy issues, as well as security issues. The authors associate these changes with changes in the country's foreign and domestic policy. In the 2000s, it is necessary to build a free democratic society, as well as solve the problems of poverty and terrorism. However, after overcoming these problems, the state and the president are faced with the tasks of maintaining living standards, maintaining power and opposing Western countries. All this was reflected in V. V. Putin's rhetoric.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
Authors: Giannangelo Carlo , Challis Matthew P , Siddiqui Ghizal , Edgar Rebecca , Malcolm Tess R , Webb Chaille T , Drinkwater Nyssa , Vinh Natalie , Macraild Christopher , Counihan Natalie , Duffy Sandra , Wittlin Sergio , Devine Shane M , Avery Vicky M , De Koning-Ward Tania , Scammells Peter , McGowan Sheena , Creek Darren J
Published: July 2024

New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target using the selective inhibitor, MIPS2673. MIPS2673 demonstrated potent inhibition of recombinant Plasmodium falciparum (PfA-M1) and Plasmodium vivax (PvA-M1) M1 metalloaminopeptidases, with selectivity over other Plasmodium and human aminopeptidases, and displayed excellent in vitro antimalarial activity with no significant host cytotoxicity. Orthogonal label-free chemoproteomic methods based on thermal stability and limited proteolysis of whole parasite lysates revealed that MIPS2673 solely targets PfA-M1 in parasites, with limited proteolysis also enabling estimation of the binding site on PfA-M1 to within ~5 Å of that determined by X-ray crystallography. Finally, functional investigation by untargeted metabolomics demonstrated that MIPS2673 inhibits the key role of PfA-M1 in haemoglobin digestion. Combined, our unbiased multi-omic target deconvolution methods confirmed the on-target activity of MIPS2673, and validated selective inhibition of M1 alanyl metalloaminopeptidase as a promising antimalarial strategy.
Early evolution of the ecdysozoan body plan
Authors: Wang Deng , Qiang Yaqin , Guo Junfeng , Vannier Jean , Song Zuchen , Peng Jiaxin , Zhang Boyao , Sun Jie , Yu Yilun , Zhang Yiheng , Zhang Tao , Yang Xiaoguang , Han Jian
Published: July 2024

Extant ecdysozoans (moulting animals) are represented by a great variety of soft-bodied or articulated organisms that may or may not have appendages. However, controversies remain about the vermiform nature (i.e. elongated and tubular) of their ancestral body plan. We describe here Beretella spinosa gen. et sp. nov. a tiny (maximal length 3 mm) ecdysozoan from the lowermost Cambrian, Yanjiahe Formation, South China, characterized by an unusual sack-like appearance, single opening, and spiny ornament. Beretella spinosa gen. et sp. nov has no equivalent among animals, except Saccorhytus coronarius, also from the basal Cambrian. Phylogenetic analyses resolve both fossil species as a sister group (Saccorhytida) to all known Ecdysozoa, thus suggesting that ancestral ecdysozoans may have been non-vermiform animals. Saccorhytids are likely to represent an early off-shot along the stem-line Ecdysozoa. Although it became extinct during the Cambrian, this animal lineage provides precious insight into the early evolution of Ecdysozoa and the nature of the earliest representatives of the group.
Regional response to light illuminance across the human hypothalamus
Authors: Campbell Islay , Sharifpour Roya , Aizpurua Jose Fermin Balda , Beckers Elise , Paparella Ilenia , Berger Alexandre , Koshmanova Ekaterina , Mortazavi Nasrin , Read John , Zubkov Mikhail , Talwar Puneet , Collette Fabienne , Sherif Siya , Phillips Christophe , Lamalle Laurent , Vandewalle Gilles
Published: July 2024

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, the subcortical circuitry underlying the stimulating impact of light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess the impact of variations in light illuminance on the regional activity of the hypothalamus while healthy young adults (N=26; 16 women; 24.3 ± 2.9y) were completing two auditory cognitive tasks. We find that, during both the executive and emotional tasks, higher illuminance triggered an activity increase over the posterior part of the hypothalamus, which includes part of the tuberomamillary nucleus and the posterior part of the lateral hypothalamus. In contrast, increasing illuminance evoked a decrease in activity over the anterior and ventral parts of the hypothalamus, encompassing notably the suprachiasmatic nucleus and another part of the tuberomammillary nucleus. Critically, the performance of the executive task was improved under higher illuminance and was negatively correlated with the activity of the posterior hypothalamus area. These findings reveal the distinct local dynamics of different hypothalamus regions that underlie the impact of light on cognition.
Mapping patterns of thought onto brain activity during movie-watching
Authors: Wallace Raven S , Mckeown Brontë , Goodall-Halliwell Ian , Chitiz Louis , Forest Philippe , Karapanagiotidis Theodoros , Mulholland Bridget , Turnbull Adam G , Vanderwal Tamera , Hardikar Samyogita , Alam Tirso Gonzalez , Bernhardt Boris , Wang Hao-Ting , Strawson Will , Milham Michael , Xu Ting , Margulies Daniel , Poerio Giulia L , Jefferies Elizabeth S , Skipper Jeremy I , Wammes Jeffery , Leech Robert , Smallwood Jonathan
Published: July 2024

Movie watching is a central aspect of our lives and an important paradigm for understanding the brain mechanisms behind cognition as it occurs in daily life. Contemporary views of ongoing thought argue that the ability to make sense of events in the ‘here and now’ depend on the neural processing of incoming sensory information by auditory and visual cortex, which are kept in check by systems in association cortex. However, we currently lack an understanding of how patterns of ongoing thoughts map onto the different brain systems when we watch a film, partly because methods of sampling experience disrupt the dynamics of brain activity and the movie-watching experience. Our study established a novel method for mapping thought patterns onto the brain activity that occurs at different moments of a film, which does not disrupt the time course of brain activity or the movie-watching experience. We found moments when experience sampling highlighted engagement with multi-sensory features of the film or highlighted thoughts with episodic features, regions of sensory cortex were more active and subsequent memory for events in the movie was better—on the other hand, periods of intrusive distraction emerged when activity in regions of association cortex within the frontoparietal system was reduced. These results highlight the critical role sensory systems play in the multi-modal experience of movie-watching and provide evidence for the role of association cortex in reducing distraction when we watch films.
Individuality across environmental context in Drosophila melanogaster
Authors: Mathejczyk Thomas F , Knief Cara , Haidar Muhammad A , Freitag Florian , McClary Tydings , Wernet Mathias F , Linneweber Gerit A
Published: July 2024

Over the past decade, several studies have demonstrated that idiosyncratic animal behaviors remain stable over long time periods. The stability of individually variable behaviors over time is often referred to as an animal’s individuality, or personality. However, most experimental studies have focused on individuality in a single, well-defined environmental context, whereas it is well-established from population studies that animal behavior is highly context-dependent. The ‘person-situation debate’ in humans and decades of observations of animal individuality under intrinsically variable natural conditions raise the question of whether and to what extent animal behavior remains stable across different situations, such as changing environmental contexts. For instance, one individual might be generally more visually guided than another, or rely only on one particular visual cue, or even on this very cue only in a specific environmental context. Here, we use a combination of both well-established and novel behavioral assays to demonstrate the relationship between individual behavior and variable environmental context under tightly controlled laboratory conditions in the model system
Drosophila melanogaster
. The stability of three individual traits (termed exploration, attention, and anxiety) was investigated under changing environmental contexts (temperature, visual cues, arena shape), in both walking and flying flies. We find that individuality is highly context-dependent, but even under the most extreme environmental alterations tested, stability of behavior always persisted in at least one of the traits. Furthermore, our quantification reveals a hierarchical order of environmental features influencing individuality. In summary, our work demonstrates that, similar to humans, fly individuality persists across different contexts, and individual differences shape behavior across variable environments, thereby making the underlying developmental and functional mechanisms amenable to genetic dissection.
PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold
Authors: Mischley Victoria , Maier Johannes , Chen Jesse , Karanicolas John
Published: July 2024

Protein-protein interactions underlie nearly all cellular processes. With the advent of protein structure prediction methods such as AlphaFold2 (AF2), models of specific protein pairs can be built extremely accurately in most cases. However, determining the relevance of a given protein pair remains an open question. It is presently unclear how to use best structure-based tools to infer whether a pair of candidate proteins indeed interact with one another: ideally, one might even use such information to screen amongst candidate pairings to build up protein interaction networks. Whereas methods for evaluating quality of modeled protein complexes have been co-opted for determining which pairings interact (e.g., pDockQ and iPTM), there have been no rigorously benchmarked methods for this task. Here we introduce PPIscreenML, a classification model trained to distinguish AF2 models of interacting protein pairs from AF2 models of compelling decoy pairings. We find that PPIscreenML out-performs methods such as pDockQ and iPTM for this task, and further that PPIscreenML exhibits impressive performance when identifying which ligand/receptor pairings engage one another across the structurally conserved tumor necrosis factor superfamily (TNFSF). Analysis of benchmark results using complexes not seen in PPIscreenML development strongly suggest that the model generalizes beyond training data, making it broadly applicable for identifying new protein complexes based on structural models built with AF2.
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior
Authors: Yonk Alex J , Linares-García Ivan , Pasternak Logan , Juliani Sofia E , Gradwell Mark A , George Arlene J , Margolis David J
Published: July 2024

The posterior medial (POm) thalamus is heavily interconnected with sensory and motor circuitry and is likely involved in behavioral modulation and sensorimotor integration. POm provides axonal projections to the dorsal striatum, a hotspot of sensorimotor processing, yet the role of POm-striatal projections has remained undetermined. Using optogenetics with slice electrophysiology, we found that POm provides robust synaptic input to direct and indirect pathway striatal spiny projection neurons (D1- and D2-SPNs, respectively) and parvalbumin-expressing fast spiking interneurons (PVs). During the performance of a whisker-based tactile discrimination task, POm-striatal projections displayed learning-related activation correlating with anticipatory, but not reward-related, pupil dilation. Inhibition of POm-striatal axons across learning caused slower reaction times and an increase in the number of training sessions for expert performance. Our data indicate that POm-striatal inputs provide a behaviorally relevant arousal-related signal, which may prime striatal circuitry for efficient integration of subsequent choice-related inputs.
Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components
Authors: Horan Mattias , Regester Daniel , Mazuski Cristina , Jahans-Price Thomas , Bailey Shanice , Thompson Emmett , Slonina Zuzanna , Plattner Viktor , Menichini Elena , Toksöz Irmak , Pinto Sandra Romero , Burrell Mark , Varsavsky Isabella , Dalgleish Henry WP , Bimbard Célian , Lebedeva Anna , Bauza Marius , Cacucci Francesca , Wills Thomas , Akrami Athena , Krupic Julija , Stephenson-Jones Marcus , Barry Caswell , Burgess Neil , O’Keefe John , Isogai Yoh
Published: July 2024

Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: the simultaneous recording of hundreds of neurons is now routinely carried out in head-restrained animals. In contrast, neural recording in unrestrained animals, as well as recording and tracking neurons over days, remains challenging, though it is possible using chronic implants. A major challenge is the availability of simple methods that can be implemented with limited or no prior experience with Neuropixels probes, while achieving reliable, reusable, versatile high-density electrophysiology. Here we developed, deployed, and evaluated the real-world performance of Repix, a chronic implantation system that permits the repeated re-use of Neuropixels probes. The lightweight system allows implanted animals to express a full range of natural behaviors, including social behaviors. We show that Repix allows the recording of hundreds of neurons across many months, up to a year, with implants across cortical and subcortical brain regions. Probes can be reused repeatedly with stable yield. Repix has been used by 16 researchers in 10 laboratories to date, and we evaluated the real-world performance of Repix in a variety of chronic recording paradigms in both mice and rats with a combined 209 implantations. We found that the key advantage of Repix is robustness and simplicity. Adopters of Repix became proficient at five procedures on average, regardless of prior experience with
in vivo
electrophysiology. With the companion protocol alongside this article, the performance and user-friendliness of Repix should facilitate a wide uptake of chronic Neuropixels recordings.
E. coli ClpB is a Robust and Processive Protein Unfoldase
Authors: Banwait Jaskamaljot Kaur , Islam Liana , Lucius Aaron L
Published: July 2024

Motor proteins of the AAA+ (ATPases Associated with Various Cellular Activity) superfamily are responsible for maintenance of the protein crowded environment of the cell.
E. coli
ClpB is a AAA+ molecular motor that, in collaboration with co-chaperones, couples the energy from ATP hydrolysis to resolving protein aggregates that form during heat shock or stress. ClpB assembles into hexameric rings and, based on structural comparison to known protein translocases or unfoldases, the motor has been proposed to processively unfold proteins and translocate the polypeptide through its axial channel. However, since the translocated polypeptide both enters and leaves the reaction without covalent modification it has proven difficult to test and quantify this model of function. Here we have developed a sequential mixing stopped-flow method that reports on processive protein unfolding and translocation catalyzed by ClpB. Using this approach, we show that ClpB processively and sequentially unfolds up to three tandem repeats of the stably folded Titin I27 domain with a maximum length of 362 amino acids. We report that ClpB unfolds ∼60 amino acids between two rate limiting steps at a rate of ∼0.9 aa s
-1
in the presence of a 1:1 mixture of ATP:ATPγS. In contrast to what was previously reported by others, in the absence of ATP, we show that ClpB efficiently couples ATPγS hydrolysis to processive unfolding at a rate of ∼0.09 aa s
-1
. Our approach solves the problem of needing covalent modification of the substrate to detect translocation. Thus, we have opened the door to addressing many questions regarding AAA+ protein function that is desperately needed to complement and test the wealth of new structural information emerging from cryo-EM studies on these motors.
Positive Play
Authors: Giesteira Bruno , Berge Gerd , Peçaibes Viviane
Published: July 2024

This book results from an initiative by the European university consortium EUGLOH - European University Alliance for Global Health - between the University of Porto, Portugal (U.P.), and the University of the Arctic, Norway (UiT). To support the activity consisting of a three-day masterclass and workshop at UiT, designated as “Tromsø Idea Camp 2024 - Developing ideas through co-creation using human-centred design,” which had as its motto: . “Identify the needs and expectations of Vardesenteret’s patients before, during, and after treatment, considering their and volunteers’ points of view and creating projectual answers that foster empathy and communication”, a handbook was created, which later formed the basis of this book. It has three sections dedicated to Person-Centred Design in the Context of Health and Well-being. The first section— ”Reported Experience”, — Relates to the doctoral project “Ludic Activities in Health Context: An Anorexia Nervosa Case in the Hospital Environment,” which systematizes Ludic methods and tools created in and for a clinical context to support the treatment and monitoring of Anorexia Nervosa. Part of the project stems from collaborative work with São João Central Hospital, Portugal, in a group dedicated to treating eating disorders. The second section - “Documented Experience” — Explores the concept of Positive Play, coined by Giesteira, B., Cardoso, P., and Peçaibes, V. in various papers and book chapters from 2021 onwards. It presents a group of methods and tools created by the authors in recent years, such as the SEED Toolkit - “SomaEsthetics for Enabling Designers” (Giesteira, B. 2023) and the ANgame Collab (Cardoso, P., Peçaibes, V., Giesteira, B. 2022). The first tool aims to work on the concept of Somaesthetics, promoting empathy and contributing to identifying feelings and sensations interdependent on body activities and movements. The second tool aims to mediate playful sessions of Participatory Design, especially in the ‘user research’ phase. Other tools and methods were selected because, based on the aforementioned authors’ experience, they are most suitable for applied research in Health Technology Design. The third section - “Lived Experience” — Records the three days of the workshop dedicated to the themes: “Emotional Design and Somaesthetics”; “Human-Centered and Participatory Design”; “Ideation, Lateral Thinking, and Prototype.” In addition to the aforementioned themes, the different phases of development of the participants' projects from the various universities of the EUGLOH university consortium are recorded, which, in a Participatory Design approach, involved the collaboration of volunteers and oncology patients from Vardesenteret. This section shares the tools used to support each phase of product or service design and the final results of the low-fidelity prototypes.
An LSTM-based optimization algorithm for enhancing quantitative arbitrage trading
Authors: Han Guodong , Li Hecheng
Published: July 2024

Arbitrage trading is a common quantitative trading strategy that leverages the long-term cointegration relationships between multiple related assets to conduct spread trading for profit. Specifically, when the cointegration relationship between two or more related series holds, it utilizes the stability and mean-reverting characteristics of their cointegration relationship for spread trading. However, in real quantitative trading, determining the cointegration relationship based on the Engle-Granger two-step method imposes stringent conditions for the cointegration to hold, which can easily be disrupted by price fluctuations or trend characteristics presented by the linear combination, leading to the failure of the arbitrage strategy and significant losses. To address this issue, this article proposes an optimized strategy based on long-short-term memory (LSTM), termed Dynamic-LSTM Arb (DLA), which can classify the trend movements of linear combinations between multiple assets. It assists the Engle-Granger two-step method in determining cointegration relationships when clear upward or downward non-stationary trend characteristics emerge, avoiding frequent strategy switches that lead to losses and the invalidation of arbitrage strategies due to obvious trend characteristics. Additionally, in mean-reversion arbitrage trading, to determine the optimal trading boundary, we have designed an optimized algorithm that dynamically updates the trading boundaries. Training results indicate that our proposed optimization model can successfully filter out unprofitable trades. Through trading tests on a backtesting platform, a theoretical return of 23% was achieved over a 10-day futures trading period at a 1-min level, significantly outperforming the benchmark strategy and the returns of the CSI 300 Index during the same period.
Growth Dynamics and Export Potential of India's Poultry Sector: A Comprehensive Analysis
Authors: Kuppan Mohanakrishnan , Ravichandran S. , Venkataraman R. , Pouchepparadjou A. , Ramesh S.
Published: July 2024

India ranks as the third largest egg producer and fifth largest producer of poultry meat globally. Commercial poultry farms accounts about eighty-five percent of countries' egg production, the remaining comes from household/backyard poultry. Poultry production plays a significant part in the socio-economic life of India's rural population. This research focused on growth trends, instability  in egg and poultry meat production and export trend, instability and Markov chain model was used to identify the market share of importing countries and stable importers of Indian poultry products. The state wise analysis revealed that the Uttar Pradesh registered highest growth rate among the top ten egg producing states for the study period. The export of poultry products has positive growth. Oman and Maldives are reliable market partners for India’s poultry product over the period.