bluuebunny/crossref_metadata_2025 huggingface dataset:
Surface and Bulk Modifications of Fibrous Erionite in Mimicked Gamble’s Solution at Acidic pH
Authors: Pacella Alessandro , Ballirano Paolo , Fantauzzi Marzia , Rossi Antonella , Viti Cecilia , Arrizza Lorenzo , Nardi Elisa , Caprioli Raffaela , Montereali Maria Rita
Published: August 2021

This study aimed at investigating both the surface and bulk modifications occurring on fibrous erionite during leaching in a mimicked Gamble’s solution (MGS) at pH of 4.5 and T = 37 °C, up to one month of incubation. Samples were characterized by a multi-analytical approach: field-emission scanning electron microscopy (FE-SEM) was employed to investigate the morphological changes of both pristine and reacted fibres, inductively coupled plasma optical emission spectrometry (ICP-OES) was used to measure the concentration of the released cations; X-ray photoelectron spectroscopy (XPS) was exploited for highlighting possible modifications of surface chemistry; X-ray powder diffraction (XRPD) and high-resolution transmission electron microscopy (HR-TEM) were applied aiming to get information on the structural state of the fibres following the incubation. ICP results integrated with those obtained by both bulk- and surface-chemical characterization highlighted that erionite binds Na especially in the first 24 h of sample incubation in the MGS, following ion exchange with the extra framework cations, in particular Ca. Moreover, our new results show that the Na binding process caused structural modifications with the migration of Na toward the Ca2 site and redistribution of the cations within the erionite cage. TEM investigation pointed out that the interaction between erionite and MGS results in the formation of a new surface amorphous layer with an irregular lobate pattern on an earlier surface weathered layer. However, the silicate framework is not weakened by incubation in the MGS at acidic pH. In addition, on the basis of the Si release normalized to the mineral surface area, fibrous erionite resulted significantly more biodurable than amphibole asbestos. Notably, considering the primary role played by biodurability in inducing pathogenicity, this result certainly supports in vivo observations showing that erionite is much more tumorigenic than asbestos. Moreover, the ions released by erionite when immersed in MGS may trigger biological effects, such as those on lipid packing and membrane permeability. On this basis, we expect a regulatory definition that would provide protection from this carcinogenic fibre.
Geochemical Anomaly Characteristics of Cd in Soils around Abandoned Lime Mines: Evidence from Multiple Technical Methods
Authors: Wei Lu , Wang Meichen , Liu Guijian , Wu Dun
Published: August 2021

Lime mines are a potential source of pollution, and the surrounding soil environment is generally at threat, especially in abandoned lime mines. This paper focuses on the study area in eastern Anhui, attempting to analyze whether Cd enrichment is related to abandoned mines. On the basis of geological investigation, this study systematically used XRD, XRF, GTS and universal Kriging interpolation to determine the distribution law of Cd in the study area, and evaluated the potential ecological risk of Cd. The results showed that the main mineral types of soil samples of red clastic rock soil parent material (RdcPm) and soil samples of carbonate soil parent material (CPm) were not completely the same. Correlation analysis showed that CaO, MgO and Cd were positively correlated with the CPm. Human activities led to the accumulation of Cd in the study area. High Cd was mainly concentrated in the northwest of the study area, which was correlated with abandoned mines and soil parent materials. The study area was dominated by slight potential risks, although some areas had medium potential risks and high potential risks. All potential high risks were in the CPm field. This study provides a scientific basis for the comprehensive utilization and development planning of soil in the study area.
Silver Nanoparticle’s Toxicological Effects and Phytoremediation
Authors: Ihtisham Muhammad , Noori Azam , Yadav Saurabh , Sarraf Mohammad , Kumari Pragati , Brestic Marian , Imran Muhammad , Jiang Fuxing , Yan Xiaojun , Rastogi Anshu
Published: August 2021

The advancement in nanotechnology has brought numerous benefits for humans in diverse areas including industry, medicine, and agriculture. The demand in the application of nanomaterials can result in the release of these anthropogenic materials into soil and water that can potentially harm the environment by affecting water and soil properties (e.g., soil texture, pH, organic matter, and water content), plants, animals, and subsequently human health. The properties of nanoparticles including their size, surface area, and reactivity affect their fate in the environment and can potentially result in their toxicological effects in the ecosystem and on living organisms. There is extensive research on the application of nano-based materials and the consequences of their release into the environment. However, there is little information about environmentally friendly approaches for removing nanomaterials from the environment. This article provides insight into the application of silver nanoparticles (AgNPs), as one of the most commonly used nanomaterials, their toxicological effects, their impacts on plants and microorganisms, and briefly reviews the possibility of remediation of these metabolites using phytotechnology approaches. This article provides invaluable information to better understand the fate of nanomaterials in the environment and strategies in removing them from the environment.
Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
Authors: Gongalsky Maxim B. , Pervushin Nikolay V. , Maksutova Daria E. , Tsurikova Uliana A. , Putintsev Pavel P. , Gyuppenen Oleg D. , Evstratova Yana V. , Shalygina Olga A. , Kopeina Gelina S. , Kudryavtsev Andrey A. , Zhivotovsky Boris , Osminkina Liubov A.
Published: August 2021

Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring of sol- and por-SiNP biodegradation using Raman and photoluminescence (PL) micro-spectroscopy. SiNPs were obtained by ultrasound grinding of sol- or por-silicon nanowires, created by silver-assisted chemical etching of crystalline Si with different doping levels. In this case, sol-SiNPs consist of nanocrystals 30 nm in size, while por-SiNPs consist of small 3 nm nanocrystals and 16 nm pores. Both SiNPs show low in vitro cytotoxicity towards MCF-7 and HEK293T cells up to 800 μg/mL. The appearance of the F-band (blue–yellow) PL, as well as a decrease in the intensity of the Raman signal, indicate the gradual dissolution of the sol-SiNPs during 20 days of incubation. At the same time, the rapid dissolution of por-SiNP within 24 h is identified by the quenching of their S-band (red) PL and the disappearance of the Raman signal. The obtained results are important for development of intelligent biodegradable drug delivery systems based on SiNPs.
Zooming in: PAGE-Northern Blot Helps to Analyze Anti-Sense Transcripts Originating from Human rIGS under Transcriptional Stress
Authors: Sadova Anastasia A. , Panteleev Dmitry Y. , Pavlova Galina V.
Published: August 2021

Ribosomal intergenic spacer (rIGS), located between the 45S rRNA coding arrays in humans, is a deep, unexplored source of small and long non-coding RNA molecules transcribed in certain conditions to help a cell generate a stress response, pass through a differentiation state or fine tune the functioning of the nucleolus as a ribosome biogenesis center of the cell. Many of the non-coding transcripts originating from the rIGS are not characterized to date. Here, we confirm the transcriptional activity of the region laying a 2 kb upstream of the rRNA promoter, and demonstrate its altered expression under transcriptional stress, induced by a wide range of known transcription inhibitors. We managed to show an increased variability of anti-sense transcripts in alpha-amanitin treated cells by applying the low-molecular RNA fraction extracted from agarose gel to PAGE-northern. Also, the fractioning of RNA by size using agarose gel slices occurred, being applicable for determining the sizes of target transcripts via RT-PCR.
Comparing Outcomes of a Digital Commercial Weight Loss Program in Adult Cancer Survivors and Matched Controls with Overweight or Obesity: Retrospective Analysis
Authors: May Christine N. , Ho Annabell Suh , Yang Qiuchen , McCallum Meaghan , Iyengar Neil M. , Comander Amy , Mitchell Ellen Siobhan , Michaelides Andreas
Published: August 2021

Maintaining a healthy weight is beneficial for cancer survivors. However, weight loss program effectiveness studies have primarily been in highly controlled settings. This is a retrospective study exploring real-world outcomes (weight loss and program engagement) after use of a digital commercial weight loss program (Noom) in cancer survivors and matched controls. All participants had voluntarily self-enrolled in Noom. Weight and engagement data were extracted from the program. Cancer-related quality of life was secondarily assessed in a one-time cross-sectional survey for survivors. Controls were a sample of Noom users with overweight/obesity who had no history of cancer but 0–1 chronic conditions. Primary outcomes were weight change at 16 weeks and program engagement over 16 weeks. Engagement included frequency of weight, food, and physical activity logging, as well as number of coach messages. Multiple regression controlling for baseline age, gender, engagement, and BMI showed that survivors lost less weight than controls (B = −2.40, s.e. = 0.97, p = 0.01). Survivors also weighed in less (survivors: 5.4 [2.3]; controls: 5.7 [2.1], p = 0.01) and exercised less (survivors: 1.8 [3.2]; controls: 3.2 [4.1], p < 0.001) than controls. However, survivors sent more coach messages (survivors: 2.1 [2.4]; controls: 1.7 [2.0], p < 0.001). Despite controls losing more weight than cancer survivors (−7.0 kg vs. −5.3 kg), survivors lost significant weight in 4 months (M = −6.2%). Cancer survivors can have success on digital commercial programs available outside of a clinical trial. However, they may require additional support to engage in weight management behaviors.
Male and Female Rats Have Different Physiological Response to High-Fat High-Sucrose Diet but Similar Myocardial Sensitivity to Ischemia-Reperfusion Injury
Authors: Fourny Natacha , Lan Carole , Bernard Monique , Desrois Martine
Published: August 2021

Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.
Coffee and Caffeine Consumption for Human Health
Authors: Abalo Raquel
Published: August 2021

Coffee is one of the most popular and consumed beverages worldwide, and caffeine is its best-known component, present also in many other beverages (tea, soft drinks, energy drinks), foodstuffs (cocoa, chocolate, guarana), sport supplements and even medicines [...]
Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients
Authors: Shono Hitoshi , Tsutsumi Rie , Beppu Kana , Matsushima Rina , Watanabe Suzuno , Fujimoto Chisa , Kanamura Ryo , Ohnishi Hiroki , Kondo Eiji , Azuma Takahiro , Sato Go , Kawai Misako , Matsumoto Hideki , Kitamura Yoshiaki , Sakaue Hiroshi , Takeda Noriaki
Published: August 2021

(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
Are They Careful Enough? Testing Consumers’ Perception of Alternative Processing Technologies on the Quality of Organic Food
Authors: Kilic Busra , Cubero Dudinskaya Emilia , Proi Migena , Naspetti Simona , Zanoli Raffaele
Published: August 2021

Given the increasing public interest in how ingredients are processed and the growing demand for organic food products, it is critical to understand consumers’ expectations about the process-related quality of organic products. Consumers perceive organic food to be nutritious, healthy and either natural or less processed, as they are afraid of the loss of nutritional, organoleptic and sensory properties of the food products. However, alternative food processing technologies might generate healthy and safe food options with nutritional quality properties. Simplified communication schemes might help to overcome this barrier for the consumer. The main objective of this study is to propose a working definition of “careful processing” for organic products and test its consistency through an experiment, while being used to rate different processing methods by consumers. Results show that the proposed definition allows the consumer to consistently rate alternative processing technologies. Consumers tend to score alternative processing technologies such as pulsed electric fields and microwaves as less careful, supporting the idea that organic consumers want as little man-made interference in their food products as possible. Results show that a simple but effective definition of careful processing may help consumers to distinguish more organic food products from conventional ones, no matter which communication scheme is used.
Continuous Protein Supplementation Reduces Acute Exercise-Induced Stress Markers in Athletes Performing Marathon
Authors: Röhling Martin , McCarthy David , Berg Aloys
Published: August 2021

The aim of this study was to determine the changes in endurance performance and metabolic, hormonal, and inflammatory markers induced by endurance stress (marathon race) in a combined strategy of training and dietary protein supplementation. The study was designed as a randomised controlled trial consisting of regular endurance training without and with a daily intake of a soy protein-based supplement over a three-month period in 2 × 15 (10 males and 5 females per group) endurance-trained adults. Body composition (body mass, BMI, and fat mass) was determined, and physical fitness was measured by treadmill ergometry at baseline and after 3 months of intervention; changes in exercise-induced stress and inflammatory markers (CK, myoglobin, interleukin-6, cortisol, and leukocytes) were also determined before and after a marathon competition; eating behaviour was documented before and after intervention by a three-day diet diary. Although no significant influence on endurance performance was observed, the protein supplementation regime reduced the exercise-induced muscle stress response. Furthermore, a protein intake of ≥20% of total energy intake led to a lower-level stress reaction after the marathon race. In conclusion, supplementary protein intake may influence exercise-induced muscle stress reactions by changing cellular metabolism and inflammatory pathways.
Studies to Improve Perinatal Health through Diet and Lifestyle among South Asian Women Living in Canada: A Brief History and Future Research Directions
Authors: Desai Dipika , Kandasamy Sujane , Limbachia Jayneel , Zulyniak Michael A. , Ritvo Paul , Sherifali Diana , Wahi Gita , Anand Sonia S. , de Souza Russell J.
Published: August 2021

South Asians (i.e., people who originate from India, Pakistan, Sri Lanka, Nepal, and Bangladesh) have higher cardiovascular disease rates than other populations, and these differences persist in their offspring. Nutrition is a critical lifestyle-related factor that influences fetal development, and infant and child health in early life. In high-income countries such as Canada, nutrition-related health risks arise primarily from overnutrition, most strikingly for obesity and associated non-communicable diseases. Evidence for developmental programming during fetal life underscores the critical influence of maternal diet on fetal growth and development, backed by several birth cohort studies including the Pune Maternal Nutrition Study, the South Asian Birth Cohort Study, and the Born in Bradford Study. Gestational diabetes mellitus is a strong risk factor for type 2 diabetes, future atherosclerosis and cardiovascular disease in the mother and increases the risk of type 2 diabetes in her offspring. Non-pharmacological trials to prevent gestational diabetes are few, often not randomized, and are heterogeneous with respect to design, and outcomes have not converged upon a single optimal prevention strategy. The aim of this review is to provide an understanding of the current knowledge around perinatal nutrition and gestational diabetes among the high-risk South Asian population as well as summarize our research activities investigating the role of culturally-tailored nutrition advice to South Asian women living in high-income settings such as Canada. In this paper, we describe these qualitative and quantitative studies, both completed and underway. We conclude with a description of the design of a randomized trial of a culturally tailored personalized nutrition intervention to reduce gestational glycaemia in South Asian women living in Canada and its implications.
18F-Fluorination Using Tri-Tert-Butanol Ammonium Iodide as Phase-Transfer Catalyst: An Alternative Minimalist Approach
Authors: Shinde Sandip S. , Bolik Kim-Viktoria , Maschauer Simone , Prante Olaf
Published: August 2021

The 18F syntheses of tracers for positron emission tomography (PET) typically require several steps, including extraction of [18F]fluoride from H2[18O]O, elution, and drying, prior to nucleophilic substitution reaction, being a laborious and time-consuming process. The elution of [18F]fluoride is commonly achieved by phase transfer catalysts (PTC) in aqueous solution, which makes azeotropic drying indispensable. The ideal PTC is characterized by a slightly basic nature, its capacity to elute [18F]fluoride with anhydrous solvents, and its efficient complex formation with [18F]fluoride during subsequent labeling. Herein, we developed tri-(tert-butanol)-methylammonium iodide (TBMA-I), a quaternary ammonium salt serving as the PTC for 18F-fluorination reactions. The favorable elution efficiency of [18F]fluoride using TBMA-I was demonstrated with aprotic and protic solvents, maintaining high 18F-recoveries of 96–99%. 18F-labeling reactions using TBMA-I as PTC were studied with aliphatic 1,3-ditosylpropane and aryl pinacol boronate esters as precursors, providing 18F-labeled products in moderate-to-high radiochemical yields. TBMA-I revealed adequate properties for application to 18F-fluorination reactions and could be used for elution of [18F]fluoride with MeOH, omitting an additional base and azeotropic drying prior to 18F-labeling. We speculate that the tert-alcohol functionality of TBMA-I promotes intermolecular hydrogen bonding, which enhances the elution efficiency and stability of [18F]fluoride during nucleophilic 18F-fluorination.
Bacterial-Specific Aggregation and Killing of Immunomodulatory Host Defense Peptides
Authors: Nazeer Nauman , Rodriguez-Lecompte Juan , Ahmed Marya
Published: August 2021

This study involves the design and development of disulfide bridge-linked antimicrobial peptides using the host defense protein Angiogenin 4 (chAng4) as a template. The mini peptides derived from chAng4 (mCA4s) were evaluated for their antibacterial efficacies in various pathogenic bacterial strains, and the role of the oxidation state of thiols in the peptide sequence and its implication on antibacterial properties were explored. A remarkable property of these synthetic mCA4 peptides is their capability to flocculate bacteria and mediate bacterial-specific killing, in the absence of any other external stimulus. mCA4s were further evaluated for their cellular uptake, hemolytic activities, toxicities, and immunomodulatory activities in different eukaryotic cell lines. The results indicate that disulfide bridge-containing cationic amphipathic peptides show superior antibacterial efficacies, are nontoxic and nonhemolytic, and mediate bacterial flocculation and killing, in the absence of external stimuli.
Novel Insights into Corema album Berries: Vibrational Profile and Biological Activity
Authors: Marques Joana , Martin Daniel , Amado Ana M. , Lysenko Viktoriya , Osório Nádia , Batista de Carvalho Luís A. E. , Marques Maria Paula M. , Barroca Maria João , Moreira da Silva Aida
Published: August 2021

This study reports an evaluation of the biological properties of the edible berries from Corema album, an endemic shrub of the Portuguese coastline, aiming at its use as a nutraceutical. Different methanolic extracts were obtained from the pulp and seed of fresh berries: pulp extract, seed residue, and seed oil (extracted and characterized for the first time). For each of these, the antioxidant activity was assessed, by different methods, as well as the antimicrobial ability. Overall, the seeds were shown to be the most nutraceutical part of the berry since they showed higher antioxidant activity, while the pulp extract displayed a significant antimicrobial capacity against several clinically relevant bacterial strains. Furthermore, the extracts were fully characterized by complementary infrared and Raman spectroscopy, revealing the presence of phenolic acids, polysaccharides, sugars, and triterpenoids in the pulp, high content of unsaturated fatty acids in the seed oil, and significant amounts of phenolics and carotenoids in the seed residue. These results pave the way for a reliable correlation between chemical composition and biological activity, in edible fruit samples.
Numerical Simulation Prediction of Erosion Characteristics in a Double-Suction Centrifugal Pump
Authors: Song Xijie , Qi Dunzhe , Xu Lijuan , Shen Yubin , Wang Wei , Wang Zhengwei , Liu Yan
Published: August 2021

The double-suction centrifugal pumps installed along the Yellow River in China face serious sediment erosion due to the high sediment content which causes the poor operation efficiency of the pump units. The particle motion characteristics and erosion characteristics in a pump under different flow rates and different particle concentrations were numerically simulated based on the particle track model of solid-liquid two-phase flow. The results show that the flow rate has a significant effect on the particle tracks and the erosion caused by the particles in the impeller. The total erosion rate is positively correlated with the flow rate, and increases with the increase in flow rate. The vortex and secondary flow in the impeller have obvious influence on the particle trajectory, which increases the particle concentration at the trailing edge of the pressure surface and intensifies the impact erosion in this area. The particles carried by the vortex intensifies the local erosion. The particle concentration mainly affects the erosion rate, but has little effect on the erosion position. The influence of flow rate on pump erosion is greater than that of the particle properties. These results provide a reference for optimization of the design of anti-erosion blades of double-suction pumps and the regulation and operation of pumping stations.
Analysis of the Status and Improvement of Microalgal Phosphorus Removal from Municipal Wastewater
Authors: Mao Yilin , Xiong Rongwei , Gao Xiufang , Jiang Li , Peng Yancong , Xue Yan
Published: August 2021

Phosphorus, as one of the main pollutants in municipal sewage, has received increasing attention recently. Phosphorus recovery also increases the sustainable development of municipal wastewater. Since algae have the ability to effectively redirect nutrients, including phosphorus, from municipal sewage to algae biomass, municipal sewage treatments involving microalgae have piqued the interest of many researchers. The phosphorus removal depends on the potential of the microalgae to absorb, preserve, or degrade phosphorus in municipal wastewater. It is, therefore, of great interest to study the mechanisms underlying the absorption, storage, and degradation of phosphorus by microalgae to ensure the viability of this phosphorus removal process in wastewater. The objectives of this review were to summarize phosphorus metabolism in microalgae, examine key external and internal factors impacting phosphorous removal by microalgae from wastewater, and examine the status of phosphorous-metabolism-related research to improve our understanding of microalgae-based municipal wastewater treatments. In addition, the methods of recovery of microalgae after phosphorous removal were summarized to ensure the sustainability of municipal wastewater treatment. Finally, a potential approach using nanomaterials was proposed to enhance the overall phosphorous removal performance in municipal wastewater through the addition of nanoparticles such as magnesium and iron.
Mono-, Bi-, and Tri-Metallic DES Are Prepared from Nb, Zr, and Mo for n-Butane Selective Oxidation via VPO Catalyst
Authors: Faizan Muhammad , Niazi Kifayat Ullah Khan , Nawaz Hasnain , Muhammad Niaz , Li Hao , Dai Fei , Zhang Ruirui , Liu Ruixia , Zhang Suojiang
Published: August 2021

In recent work, deep eutectic solvents (DESs) as ionic liquid analogues have been abundantly used in catalysis. Herein, vanadium phosphorus oxide (VPO) catalysts were synthesized from mono-, bi-, and tri- metallic DES of Nb, Zr, and Mo metal dopants as structure-directing agents and electronic promoters for n-butane selective oxidation towards maleic anhydride. Higher MA selectivity and larger n-butane conversion was successfully obtained using the newly developed catalysts, while oxidation by-product COx (CO, CO2) was minimized. Characterization techniques including FTIR, DSC, XRD, TEM, SEM, EDS, Raman spectroscopy, TGA, XPS, and NH3-TPD were employed to fully characterize the DESs, precursors and catalysts. This work led to an increase of 7.8% in MA mass yield with 16% more n-butane conversion as compared to an unpromoted VPO catalyst. Moreover, the utilization of a low-carbon alkane brought in a green impact on the chemical plant as well as the environment.
Evaluating the Presence of Software-as-a-Medical-Device in the Australian Therapeutic Goods Register
Authors: Ceross Aaron , Bergmann Jeroen
Published: August 2021

In recent years, medical device regulatory bodies have recognised software-as-a-medical-device (SaMD) as a distinct subgroup of devices. The field of SaMD has been rapidly evolving and encompasses a range of different digital solutions. Many organisations have now started to look into digital healthcare, as a way to solve key global challenges. However, there remains uncertainty regarding how many of these SaMD products are entering the market and to what extent these systems achieve a desired level of general safety once they are in the market. In this study, we utilise data collected from publicly available databases. The data are evaluated for trends and a descriptive analysis is performed of the recall and adverse events associated specifically with SaMD. We find that there is a significant positive trend (p < 0.05) of SaMD registrations, although the number of SaMD registrations remains relative low compared to non-SaMD. This rise in SaMD registrations coincides with increasing levels of recalls and adverse events. More importantly, it becomes apparent that adverse events notification is not yet fit for purpose with regards to SaMD.
Detection of Brominated Plastics from E-Waste by Short-Wave Infrared Spectroscopy
Authors: Bonifazi Giuseppe , Fiore Ludovica , Gasbarrone Riccardo , Hennebert Pierre , Serranti Silvia
Published: August 2021

In this work, the application of Short-Wave Infrared (SWIR: 1000–2500 nm) spectroscopy was evaluated to identify plastic waste containing brominated flame retardants (BFRs) using two different technologies: a portable spectroradiometer, providing spectra of single spots, and a hyperspectral imaging (HSI) platform, acquiring spectral images. X-ray Fluorescence (XRF) analysis was preliminarily performed on plastic scraps to analyze their bromine content. Chemometric methods were then applied to identify brominated plastics and polymer types. Principal Component Analysis (PCA) was carried out to explore collected data and define the best preprocessing strategies, followed by Partial Least Squares—Discriminant Analysis (PLS-DA), used as a classification method. Plastic fragments were classified into “High Br content” (Br > 2000 mg/kg) and “Low Br content” (Br < 2000 mg/kg). The identified polymers were acrylonitrile butadiene styrene (ABS) and polystyrene (PS). Correct recognition of 89–90%, independently from the applied technique, was achieved for brominated plastics, whereas a correct recognition ranging from 81 to 89% for polymer type was reached. The study demonstrated as a systematic utilization of both the approaches at the industrial level and/or at laboratory scale for quality control can be envisaged especially considering their ease of use and the short detection response.
Tear Liquid for Predictive Diagnosis of Alzheimer’s Disease
Authors: Del Prete Salvatore , Marasco Daniela , Sabetta Rosalaura , Del Prete Antonio , Marino Federica Zito , Franco Renato , Troisi Salvatore , Troisi Mario , Cennamo Gilda
Published: August 2021

The common approach of the diagnosis of Alzheimer’s Disease (AD) is made with an analysis of the cerebrospinal fluid or the study of retinal fundus and the plaques formation through optical corneal tomography (OCT), or more simply with a fundus camera. Tears analysis is widely discussed in literature as an essential method to describe molecular and biochemical alterations in different diseases. The aim of our study was the identification with immunocytochemistry of Amyloid Beta-42 in tears from patients with or without familiarity for Alzheimer Disease, in order to make the diagnosis earlier and more accessible compared to other invasive methods. Our study was performed on tears from three phenotypically healthy subjects: two of them were Caucasian with Alzheimer familiarity (48 and 55 years old) and the other one was Asian without Alzheimer familiarity (45 years old) and affected by an adenoviral keratoconjunctivitis at the moment of withdrawal. Tear samples were collected from eye fornix and were examinated by immunocytochemistry (ICC) assay using anti-Amyloid Beta X-42 antibody. Two out of three tears samples showed positive Amyloid Beta-42. Considering that our patients were phenotypically healthy, the identification of Amyloid Beta-42 by ICC could be a candidable method to make the diagnosis of the disease earlier and more accessible and available then other current and invasive methods and it could be a candidate for a screening method too.
Sentinel-2 and Landsat-8 Multi-Temporal Series to Estimate Topsoil Properties on Croplands
Authors: Castaldi Fabio
Published: August 2021

The spatial and temporal monitoring of soil organic carbon (SOC), and other soil properties related to soil erosion, is extremely important, both from the environmental and economic perspectives. Sentinel-2 (S2) and Landsat-8 (L8) time series increase the probability to observe bare soil fields in croplands, and thus, monitor soil properties over large regions. In this regard, this work suggests an automated pixel-based approach to select only pure soil pixels in S2 and L8 time series, and to make a synthetic bare soil image (SBSI). The SBSIs and the soil properties measured in the framework of the European LUCAS survey were used to calibrate SOC, clay, and CaCO3 prediction models. The results highlight a high correlation between laboratory soil spectra and the SBSIs median spectra, especially for the SBSI obtained by a three-year S2 collection, which provides satisfactory results in terms of SOC prediction accuracy (RPD: 1.74). The comparison between S2 and L8 results demonstrated the higher capability of the S2 sensor in terms of SOC prediction accuracy, mainly due to the greater spatial resolution of the bands in the visible region. Whereas, neither S2 nor L8 could accurately predict the clay and CaCO3 content. This is because of the low spectral and spatial resolution of their SWIR bands that prevent the exploitation of the narrow spectral features related to these two soil attributes. The results of this study prove that large S2 time series can estimate and monitor SOC in croplands using an automated pixel-based approach that selects pure soil pixels and retrieves reliable synthetic soil spectra.
Modeling the Relationship of ≥2 MeV Electron Fluxes at Different Longitudes in Geostationary Orbit by the Machine Learning Method
Authors: Sun Xiaojing , Lin Ruilin , Liu Siqing , He Xinran , Shi Liqin , Luo Bingxian , Zhong Qiuzhen , Gong Jiancun
Published: August 2021

The energetic electrons in the Earth’s radiation belt, known as “killer electrons”, are one of the crucial factors for the safety of geostationary satellites. Geostationary satellites at different longitudes encounter different energetic electron environments. However, organizations of space weather prediction usually only display the real-time ≥2 MeV electron fluxes and the predictions of ≥2 MeV electron fluxes or daily fluences within the next 1–3 days by models at one location in GEO orbit. In this study, the relationship of ≥2 MeV electron fluxes at different longitudes is investigated based on observations from GOES satellites, and the relevant models are developed. Based on the observations from GOES-10 and GOES-12 after calibration verification, the ratios of the ≥2 MeV electron daily fluences at 135° W to those at 75° W are mainly in the range from 1.0 to 4.0, with an average of 1.92. The models with various combinations of two or three input parameters are developed by the fully connected neural network for the relationship between ≥2 MeV electron fluxes at 135° W and 75° W in GEO orbit. According to the prediction efficiency (PE), the model only using log10 (fluxes) and MLT from GOES-10 (135° W), whose PE can reach 0.920, has the best performance to predict ≥2 MeV electron fluxes at the locations of GOES-12 (75° W). Its PE is larger than that (0.882) of the linear model using log10 (fluxes four hours ahead) from GOES-10 (135° W). We also develop models for the relationship between ≥2 MeV electron fluxes at 75° W and at variable longitudes between 95.8° W and 114.9° W in GEO orbit by the fully connected neural network. The PE values of these models are larger than 0.90. These models realize the predictions of ≥2 MeV electron fluxes at arbitrary longitude between 95.8° W and 114.9° W in GEO orbit.
Classification and Evaluation of Extended PICS (EPICS) on a Global Scale for Calibration and Stability Monitoring of Optical Satellite Sensors
Authors: Fajardo Rueda Juliana , Leigh Larry , Teixeira Pinto Cibele , Kaewmanee Morakot , Helder Dennis
Published: August 2021

Historically stable areas across North Africa, known as pseudo invariant calibration sites (PICS), have been used as targets for the calibration and monitoring of optical satellite sensors. However, two major drawbacks exist for these sites: first is the dependency on a single location to be always invariant, and second is the limited amount of observation achieved using these sites. As a result, longer time periods are necessary to construct a dense dataset to assess the radiometric performance of on-orbit optical sensors and confirm that the change detected is sensor-specific rather than site-specific. This work presents a global land cover classification to obtain an extended pseudo invariant calibration site (EPICS) on a global scale using Landsat-8 Operational Land Imager (OLI) data. This technique provides multiple calibration sites across the globe, allowing for the building of richer datasets in a shorter time frame compared to the traditional approach (PICS), with the advantage of assessing the calibration and stability of the sensors faster, detecting possible changes sooner and correcting them accordingly. This work identified 23 World Reference System two (WRS-2) path/row locations around the globe as part of the global EPICS. These EPICS have the advantage of achieving multiple observations per day, with similar spectral characteristics compared to traditional PICS, while still producing a temporal coefficient of variation (ratio of temporal standard deviation and temporal mean) less than 4% for all bands, with some as low as 2.7%.
Forest Leaf Mass per Area (LMA) through the Eye of Optical Remote Sensing: A Review and Future Outlook
Authors: Gara Tawanda W. , Rahimzadeh-Bajgiran Parinaz , Darvishzadeh Roshanak
Published: August 2021

Quantitative remote sensing of leaf traits offers an opportunity to track biodiversity changes from space. Augmenting field measurement of leaf traits with remote sensing provides a pathway for monitoring essential biodiversity variables (EBVs) over space and time. Detailed information on key leaf traits such as leaf mass per area (LMA) is critical for understanding ecosystem structure and functioning, and subsequently the provision of ecosystem services. Although studies on remote sensing of LMA and related constituents have been conducted for over three decades, a comprehensive review of remote sensing of LMA—a key driver of leaf and canopy reflectance—has been lacking. This paper reviews the current state and potential approaches, in addition to the challenges associated with LMA estimation/retrieval in forest ecosystems. The physiology and environmental factors that influence the spatial and temporal variation of LMA are presented. The scope of scaling LMA using remote sensing systems at various scales, i.e., near ground (in situ), airborne, and spaceborne platforms is reviewed and discussed. The review explores the advantages and disadvantages of LMA modelling techniques from these platforms. Finally, the research gaps and perspectives for future research are presented. Our review reveals that although progress has been made, scaling LMA to regional and global scales remains a challenge. In addition to seasonal tracking, three-dimensional modeling of LMA is still in its infancy. Over the past decade, the remote sensing scientific community has made efforts to separate LMA constituents in physical modelling at the leaf level. However, upscaling these leaf models to canopy level in forest ecosystems remains untested. We identified future opportunities involving the synergy of multiple sensors, and investigated the utility of hybrid models, particularly at the canopy and landscape levels.
Reviewing the Potential of Sentinel-2 in Assessing the Drought
Authors: Varghese Dani , Radulović Mirjana , Stojković Stefanija , Crnojević Vladimir
Published: August 2021

This paper systematically reviews the potential of the Sentinel-2 (A and B) in assessing drought. Research findings, including the IPCC reports, highlighted the increasing trend in drought over the decades and the need for a better understanding and assessment of this phenomenon. Continuous monitoring of the Earth’s surface is an efficient method for predicting and identifying the early warnings of drought, which enables us to prepare and plan the mitigation procedures. Considering the spatial, temporal, and spectral characteristics, the freely available Sentinel-2 data products are a promising option in this area of research, compared to Landsat and MODIS. This paper evaluates the recent developments in this field induced by the launch of Sentinel-2, as well as the comparison with other existing data products. The objective of this paper is to evaluate the potential of Sentinel-2 in assessing drought through vegetation characteristics, soil moisture, evapotranspiration, surface water including wetland, and land use and land cover analysis. Furthermore, this review also addresses and compares various data fusion methods and downscaling methods applied to Sentinel-2 for retrieving the major bio-geophysical variables used in the analysis of drought. Additionally, the limitations of Sentinel-2 in its direct applicability to drought studies are also evaluated.
A Multi-Scale Spatial Attention Region Proposal Network for High-Resolution Optical Remote Sensing Imagery
Authors: Dong Ruchan , Jiao Licheng , Zhang Yan , Zhao Jin , Shen Weiyan
Published: August 2021

Deep convolutional neural networks (DCNNs) are driving progress in object detection of high-resolution remote sensing images. Region proposal generation, as one of the key steps in object detection, has also become the focus of research. High-resolution remote sensing images usually contain various sizes of objects and complex background, small objects are easy to miss or be mis-identified in object detection. If the recall rate of region proposal of small objects and multi-scale objects can be improved, it will bring an improvement on the performance of the accuracy in object detection. Spatial attention is the ability to focus on local features in images and can improve the learning efficiency of DCNNs. This study proposes a multi-scale spatial attention region proposal network (MSA-RPN) for high-resolution optical remote sensing imagery. The MSA-RPN is an end-to-end deep learning network with a backbone network of ResNet. It deploys three novel modules to fulfill its task. First, the Scale-specific Feature Gate (SFG) focuses on features of objects by processing multi-scale features extracted from the backbone network. Second, the spatial attention-guided model (SAGM) obtains spatial information of objects from the multi-scale attention maps. Third, the Selective Strong Attention Maps Model (SSAMM) adaptively selects sliding windows according to the loss values from the system’s feedback, and sends the windowed samples to the spatial attention decoder. Finally, the candidate regions and their corresponding confidences can be obtained. We evaluate the proposed network in a public dataset LEVIR and compare with several state-of-the-art methods. The proposed MSA-RPN yields a higher recall rate of region proposal generation, especially for small targets in remote sensing images.
Screening of Volatile Compounds in Mate (Ilex paraguariensis) Tea—Brazilian Chimarrão Type—By HS-SPDE and Hydrodistillation Coupled to GC-MS
Authors: Kaltbach Pedro , Gillmeister Marit , Kabrodt Kathrin , Schellenberg Ingo
Published: August 2021

The volatile fraction of mate (Ilex paraguariensis) tea—specifically Brazilian chimarrão type, which has an odor profile comprising distinctive fresh, green, grass, and herbal notes—was investigated. Hydrodistillation in a Clevenger apparatus was employed in order to extract volatiles from the tea matrix. Headspace–solid-phase dynamic extraction (HS-SPDE) was employed to extract the volatiles from two types of infusions of this tea—a simple single infusion and a traditional preparation of consecutive infusions. Volatiles were analyzed by gas chromatography–flame ionization detection/mass spectrometry (GC-FID/MS). In total, 85 compounds were either identified or tentatively identified and semi-quantified. Semi-quantification comprised peak area integration of all the peaks (including the unidentified ones) in the chromatogram. Results obtained by hydrodistillation and by HS-SPDE were distinct, covering mostly different ranges of volatility and showing only 15 compounds in common. The identified compounds had their respective average and minimum odor thresholds and odor characteristics compiled from the literature. Several major compounds considered as key odorants in other mate tea products were not detected or only present at low levels in the samples of this research. Approximately half of the odorants identified in these samples were commonly reported in different mate tea types; the remaining 41 molecules—predominantly terpenoids (isoprenoids)—could be listed as specific to the Brazilian chimarrão type and are suggested to underlie its typical freshness.
Consistency or Hypocrisy? The Impact of Internal Corporate Social Responsibility on Employee Behavior: A Moderated Mediation Model
Authors: Chang Yi-Ping , Hu Hsiu-Hua , Lin Chih-Ming
Published: August 2021

Adopting social identity theory, this study examined the process linking the relations between internal corporate social responsibility (InCSR), work engagement, and turnover intention by focusing on the mediating influence of organizational identification and the moderating role of perceived corporate hypocrisy. Data were obtained from 311 medical staff (excluding supervisors and managers) of a public regional teaching hospital in Taiwan. The results revealed that employees are more dedicated to work and less inclined to leave the firm if they perceive that InCSR is implemented within the firm. However, if an employee perceives corporate hypocrisy of inconsistency between communication and actual actions, it may have the opposite effect on employees. Likewise, the higher the level of perceived corporate hypocrisy, the lesser the positive effect of InCSR on employee behavior. Finally, the implications, limitations, and suggestions for future research were discussed.