bluuebunny/crossref_metadata_2025 huggingface dataset:
An efficient load balancing technique using CAViaR-HHO enabled VM migration and replica management in cloud computing
Authors: George Shelly Shiju , Pramila R. Suji
Published: January 2023

Cloud computing is immense technology that offers distributed resources to a number of users who are present throughout the world. Cloud model is comprised of numerous virtual machines (VMs) and physical machines (PMs) to carry out user tasks effectively in a parallel manner but in some cases, the demand of the users may be high that resulting in the overloading of PMs and this condition deteriorates the performance of cloud network. For achieving effective virtualization in the cloud paradigm, energy and resource utilization are major properties that should be handled effectively and such properties are accomplished through effective management of workload by distributing load equivalently among VMs. By doing so, resource utilization of the network is enhanced and it only requires minimum energy to process the tasks. Numerous load-balancing algorithms have been introduced earlier to maintain load in a cloud environment, nevertheless, they are devoid of mitigating the number of task migrations. Hence, this research proposes an effective load balancing algorithm and replica management method using the proposed Conditional Autoregressive Value at risk by Regression Quantiles-Horse Herd Optimization (CAViaR-HHO) model. Here, the load is computed by considering some factors like Central Processing Unit (CPU), Million Instructions per Second (MIPS), bandwidth, memory, and frequency. VM migration and replica migration is effectively carried out using the proposed CAViaR-HHO model. Meanwhile, the developed method is devised by integration of Conditional Autoregressive Value at risk by Regression Quantiles (CAViaR) with Horse Herd Optimization Algorithm (HOA). However, the proposed CAViaR-HHO has achieved a load with a minimum value of 0.109, capacity with a maximum value of 0.591, resource utilization with a maximum value of 0.467, and minimum cost of 0.344. Using setup-1, when the number of tasks is 500, the capacity of the proposed method is 5.58%, 3.89%, 2.87%, 1.52%, and 0.67% higher when compared to the existing approaches namely, C-FDLA, K-means clustering + LB, Adaptive starvation threshold, EIMORM, and Dynamic replica creation method.
Carl Friedrich’s Path to “Totalitarianism”
Authors: Turner Stephen
Published: January 2023

Carl Friedrich produced a list of characteristics of totalitarianism that for nearly a decade was influential as a “theory of totalitarianism” and a point of reference afterward. It was the product of Friedrich’s long and complex intellectual engagement with the theory of the modern state, beginning with his defense of the use of Article 48 in 1930, and his developing thinking as he became an activist in the “defense of democracy” and a war advocate, and later as a participant in the American occupation. Friedrich’s political theory, however, reflected sources and problematics in the German tradition that led him in the direction of the discretionary but “rational” bureaucratic state, and against the standard American understanding of law and constitutional order. His thinking reflected his hostility to Max Weber, Hans Kelsen, and other Continental liberals, and a strong belief that the modern state required a bureaucracy free from supervision and operated by a “responsible elite” rather than governed by direct democratic controls or parliamentary supervision. He was criticized by Herbert Finer in a long-running controversy for the anti-democratic character of his views, as well as by Joseph Dorfman, who pointed out his twisting of political language. His commitments to his view of the state blocked him from criticizing the new regimes of National Socialism and Stalinism in the conventional terms of lack of freedom, the rule of law, democratic accountability, and constitutional literalism which defined the American vernacular conception of politics, all of which he had debunked. Instead, he treated the differences with these new “totalitarian” orders as exaggerations of features of normal democratic regimes which together, and together with new technologies, constituted a historically novel political form. He thus clashed with Harold Lasswell, whose concept of a Garrison State was a rival conception that he differed from by arguing that party control of the state apparatus was an essential feature of totalitarian societies.
Comparative Evaluation of Antimicrobial Efficacy of Aloe Barbadensis Miller, Curcuma Longa and Azadirachta Indica with Sodium Hypochlorite: An Invitro Study
Authors: James Dr. Vandana , Balagopal Dr.Sundaresan. , Charanya Dr.C. , .L Marshal , S Nandhini.
Published: January 2023

Context: The thorough removal of microflora, debris, and irritants from the root canal system is necessary for root canal treatment to be effective. Herbal or natural products are becoming more popular recently as a result of their strong antibacterial activity, biocompatibility, anti-inflammatory, and anti-oxidant properties

Aims: To compare and evaluate antimicrobial efficacy of herbal extracts Aloe barbadensis miller, Curcuma longa and Azadirachta indica with 2.5% sodium hypochlorite against the Enterococcus faecalis .

Settings and Design: Forty muller Hinton agar plates were taken as sample and were grouped into 4 groups as Group I: 2.5% NaOCl ,Group II: Curcuma longa extract ,Group III: Azadirachta indica extract, Group IV: Aloe barbadensis miller.

Methods and Material: The agar plates were inoculated with strains of E.faecalis (ATCC29212) and test solutions were placed in agar wells in group 1-4. The agar plates were incubated at 37 0C for 72 hours. After incubating, the agar plates were examined for zone of inhibition for assessing the degree of susceptible or resistance of test organism.

Statistical analysis used: Statistical analysis was performed using Oneway Anova test with statistical significance at P < 0.05.

Results: It was shown that Curcuma longa was highly efficient similar to 2.5%NaOCl

Conclusions: Curcuma longa extract has a significant antimicrobial efficacy against Enterococcus faecalis similar to 2.5% sodium hypochlorite

Key Messages: Herbal irrigants are best alternative to gold standard chemical endodontic irrigants. With their increase in antimicrobial properties, they aid in complete removal of endodontic microorganisms.
Measuring the Post-Training Effectiveness of New Training Programs: A Study on DIKLAT PIM Reformer Model
Authors: Kamis Ruslan , Jabid Abdullah W , Rajak Adnan , Fahri Johan
Published: January 2023

Studies have shown indications of performance improvement due to a training program. In the public sector, this program is highly expected to impact how the officers can demonstrate their capacity to perform their duties well. This program includes a new leadership education and training program called DIKTLAT PIM Model Reformer. This study was aimed at contextually examining the effectiveness of this new model of a training program. This study demonstrated how the basic rule (Regulation of the Head of State Administration Agency Number 13 of 2013 concerning Guidelines for Organizing Level IV Leadership Education and Training) on post-training evaluation was conducted. This current study’s novelty lies in its use of the grounded theory method as an evaluation approach for post-training effectiveness. This current study used the Grounded Theory Method (GTM) and focused on alumni training at the Municipality of Tidore Islands, North Maluku, Indonesia. The results indicated several aspects identified and defined by the alumni concerning the new training program model. The aspects include effectiveness and efficiency improvement, competency measures, leader morality and professionalism, teamwork, source financing, and performance evaluation. This current study enabled its basic regulation on measuring the effectiveness of the training program—DIKTLAT PIM Model Reformer. Future studies are also proposed to overcome this study’s weakness.
MEDIA MASSA CETAK PADA MASA PANDEMI VIRUS COVID 19: HIDUP ATAU MATI
Authors: Koesanto Stefani Made Ayu Artharini , Rubyasih Arina , Rahmaddian Rahmaddian
Published: January 2023

Tulisan ini ingin membahas mengenai bagaimana perubahan kebiasaan masyarakat khususnya di Indonesia terutama di Kalimantan Tengah, Jawa Barat dan Kalimantan Utara dalam mengkonsumsi informasi melalui media karena pandemi virus Covid 19 berpengaruh pada keberadaan dan kehidupan media massa cetak. Penelitian kualitatif ini dilakukan dengan mengambil data tertulis kuisioner terbuka kepada beberapa responden wartawan dan pimpinan media massa cetak di Kalimantan Tengah, Jawa Barat dan Kalimantan Utara. Disimpulkan bahwa media massa yang masih bertahan menerapkan strategi khusus agar dapat bertahan pada masa pandemi virus covid 19 yaitu dengan melakukan efisiensi, digitalisasi koran, konvergensi media, memperkuat sisi konten (diversifikasi konten) dan melakukan modifikasi desain visual yang menarik perhatian pembaca. Media juga melakukan komunikasi pemasaran dengan memperkuat kerjasama dengan pemerintah, pihak swasta dan masyarakat terutama dalam memberikan berita yang kredibel menjadi tumpuan bagi perusahaan untuk tetap bertahan. Peneliti menyarankan agar dapat mempertahankan eksistensinya media massa cetak harus bisa menekankan kredibelitas sesuai dengan penerapan kode etik jurnalistik, dan memperkuat berita lokal yang berbeda dengan media online agar tetap diminati oleh masyarakat lokal.
PENINGKATAN HASIL BELAJAR SISWA IPS MATERI KETERGANTUNGAN ANTAR RUANG DI LIHAT DARI KONSEP EKONOMI DAN PENGARUHNYA TERHADAP KESEJAHTRAAN MASYARAKAT MELALUI MODEL QUANTUM TEACHING DI KELAS IX SMP NEGERI 2 MUARA TEWEH TAHUN PELAJARAN 2021/2022
Authors: Rusdiana Rusdiana
Published: January 2023

Dalam hasil pengamatan,  pada mapel IPS khususnya materi ketergantungan antar ruang di lihat dari konsep ekonomi dan pengaruhnya terhadap kesejahtraan masyarakat, siswa Kelas IX SMP Negeri 2 Muara Teweh menunjukkan hasil belajar yang rendah, hal ini di tunjukkan adanya nilai harian yang rendah atau tidak mencapai KKM.  Oleh karenanya disini, guru berinisiatif menggunakan model pembelajaran yang tidak biasa di pakai di kelas, yakni menggunakan Model Quantum Teaching.

Penelitian tindakan kelas ini dilakukan di SMP Negeri 2 Muara Teweh, Pendekatan Penelitian ini menggunakan pendekatan kualitatif kuantitatif. Rancangan penelitian metode campuran. sedangkan sampel penelitian ini adalah siswa Kelas IX SMP Negeri 2 Muara Teweh. Teknik Pengumpulan data terdiri dari teknik tes dan non tes.

Pada Pra siklus jumlah siswa tuntas belajar hanya mencapai 9 siswa dan skor hasil observasi hanya mencapai 48 Aktifitas siswa di dalam kelas kurang baik. Pada siklus I Jumlah Siswa Tuntas Belajar mencapai 21 siswa, nilai rata-rata mencapai 77,22 Artinya Model Quantum Teaching efektif di gunakan untuk meningkatkan hasil belajar siswa.

Hasil observasi menunjukkan skor 111  Artinya Aktifitas siswa di dalam kelas cukup baik. Akan tetapi agar lebih kondusif lagi, maka peneliti hendak melaksanakan siklus II. Pada siklus II Jumlah Siswa Tuntas Belajar mencapai 32 siswa, nilai rata-rata mencapai 82,5. Artinya Model Quantum Teaching efektif di gunakan untuk meningkatkan hasil belajar siswa pada materi Ketergantungan antar ruang di lihat dari konsep ekonomi dan pengaruhnya terhadap kesejahtraan masyarakat.  Hasil observasi menunjukkan skor 144  Artinya Aktifitas siswa di dalam kelas sangat baik.
ANALISIS PELAKSANAAN PEMBELAJARAN BERBASIS BLENDED LEARNING PADA MATA PELAJARAN IPS
Authors: Jailani Muhammad , Fauziah Siti
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan pembelajaran berbasis blended learning pada mata pelajaran IPS dikelas VIII di SMP Mhammadiyah Palangka Raya. Penelitian ini terdiri tas dua subfokus yaitu  pelaksanaan pembelajaran berbasis blended learning dan penerapan blended learning  tersebut pada mata pelajaran IPS.

Penelitian ini menggunakan pendekatan kualitatif dengan menggunakan metode deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah teknik observasi, wawancara dan dokumentasi. Informan dalam penelitian ini berjumlah 11 orang terdiri dari 1 orang guru mata pelajaran IPS, dan 10 peserta didik.

Hasil penelitian menunjukan bahwa: (1) pelaksanaan pembelajaran pada masa pandemi seperti ini sudah diterapkan oleh sekolah dan dinilai efektif oleh guru dan juga peserta didik. (2) peserta didik lebih tertarik dengan pembelajaran blended learning  dibandingkan dengan pembelajaran E-learning. (3) banyak manfaat yang didapatkan peserta didik pada saat pelaksanaan pembelajaran blended learning.
Definicyjne i metodologiczne dylematy badań karier oraz sukcesu zawodowego
Authors: Czeranowska Olga
Published: January 2023

W tekście dokonano przeglądu podejść teoretycznych do definiowania pojęcia kariery zawodowej z uwzględnieniem sukcesu zawodowego jako jej elementu. W pierwszej części zaprezentowano wybrane wątki teoretyczne związane z definiowaniem pojęcia kariery, w tym jej wymiar czasowy oraz subiektywne i obiektywne rozumienia pojęcia. Omówiono również różnice pomiędzy tradycyjnym a nowymi modelami karier. Druga część jest poświęcona pojęciu sukcesu zawodowego w jego wymiarze subiektywnym i obiektywnym. Uwzględnione zostały również kolejne poziomy definiowania sukcesu, od osobistego po ogólnospołeczny. W trzeciej części tekstu została podjęta próba przełożenia refleksji teoretycznej dotyczącej definiowania pojęć kariery zawodowej oraz sukcesu na podejścia metodologiczne, zarówno w obszarze metod ilościowych, jak i jakościowych.
Rethinking the Basic Police Training Policy in Bosnia and Herzegovina
Authors: Sikimić Milica
Published: January 2023

Several terrorist attacks have occurred in Bosnia and Herzegovina in the 21st century, and all the security agencies in the country are dealing with the prevention and counteraction of terrorism. Training of police officers is conducted in three different training centres, and law enforcement officers have an average of 25 working weeks of basic police training. The main goal of this paper is to examine the representation of the topics of prevention and counterterrorism in the curricula of basic/entry police training conducted in Bosnia and Herzegovina (BIH). The results obtained revealed that it is possible for a police officer (policeman) or criminal inspector to not have had a single lesson on the topic of terrorism during their training.
Pathogenetic and etiologic considerations of febrile seizures
Authors: Han Ji Yoon , Han Seung Beom
Published: January 2023

Febrile seizure (FS), which occurs in febrile children without underlying health problems, is the most common type of seizure disorder in children. The suggested pathogenesis of FS derived from several animal and human studies is multifactorial and debatable. Neuronal hyperexcitability, which develops during inflammatory responses that accompany fever, provokes seizures. However, the exact role of each inflammatory mediator (e.g., cytokines) is undefined in terms of the connection between systemic or local inflammation and the central nervous system, and the mechanisms by which cytokines increase neuronal excitability remain unclear. In contrast, the cause of fever in most children with FS is usually mild respiratory virus infection (e.g., rhinovirus, influenza virus, adenovirus, and enterovirus) rather than severe bacterial infections. In temperate regions, the major causative respiratory viruses seem to mirror seasonally prevalent respiratory viruses in the community. Therefore, vigorous efforts to identify the causative pathogen of fever may not be necessary in children with FS. Genetic factors seem to play a role in neuronal hyperexcitability, and some types of genetic variation have been identified in several genes encoding ion channels of neurons that participate in neuronal excitation. Although most children with FS have benign outcomes, some characteristics such as complex FS, febrile status epilepticus, consecutive afebrile seizures, and the presence of neurodevelopmental disabilities may require further genetic and neurologic evaluations.
Trends in the interannual variability of nutrients in the northeastern part of the Black Sea according to ship observations for 2017-2021
Authors: Chasovnikov Valeriy K. , Borodulina Polina A.
Published: January 2023

The results of long-term oceanological studies that were carried out as part of the Black Sea 2017–2021 complex scientific expedition and are devoted to the study of the coastal zone of the sea based on monitoring observations are presented.
During all five years, a stable trend of a decrease in the content of silicon in the active layer of the coastal-shelf zone of the sea was observed. During the last 3 years, there has been an increase in the reserves of mineral phosphorus and a decrease in the content of mineral nitrogen. As a result of this variability in the content of phosphorus, nitrogen and silicon, during 2021, such stoichiometric relationships between them were established that a rare situation arose in the hydrochemical regime of the Black Sea waters. Phosphorus ceases to be the main element limiting the processes of development of biological communities, and among the three main biogenic elements, any of the parameters could act as a limiting factor or have a joint limiting effect on the development of photosynthesis.
Clinical application of noninvasive left ventricular myocardial work indices
Authors: Ivanov S. I. , Alekhin M. N.
Published: January 2023

This article is the description of three clinical cases of the application of a new echocardiographic technique — the estimation of the left ventricular (LV) myocardial work parameters by constructing pressure - strain loops in patients with arterial hypertension, hypertrophic and dilated cardiomyopathies. The specific variations of global and regional LV myocardial work indices distribution, typical for each pathology, are clearly demonstrated, the results of current scientific studies on each disease are also briefly presented.
Electrodiagnostic features of myasthenia gravis in patient with predominantly bulbar symptoms. Case report
Authors: Seliverstova E. G. , Sinkin M. V. , Voitenkov V. B.
Published: January 2023

Myasthenia gravis is an autoimmune disease, the clinical manifestations of which are in the form of weakness and pathological muscle fatigue. We present the clinical case of a patient with predominantly lingual muscle involvement. The patient was diagnosed with a generalized 2A–2B form of myasthenia gravis. Dysarthria and weakness of the masticatory muscles were observed at the onset of the disease. The diagnosis was established 1.5 months after the appearance of the first complaints. Diagnosis at the outpatient stage was hampered by the epidemiological history and the short duration of symptoms that occurred only after eating. All of the above determines the importance of clinician`s alertness about the possibility of this disease manifesting itself in such a rather specific and rare group of symptoms.
Modern view on pathogenesis, diagnosis and treatment of Gilbert's syndrome
Authors: Levitan B. N. , Skvortsov V. V. , Morozov A. V. , Serdyukova T. V.
Published: January 2023

Gilbert’s syndrome is an autosomal recessive inherited disorder of bilirubin glucuronidation characterized by unconjugated hyperbilirubinaemia in the absence of hepatocellular injury or hemolysis. Gilbert’s syndrome is characterized by mutations to the UGT1A1 gene which encodes the enzyme uridine disphosphate glucuronоsyltransferase which is required for the conjugation and subsequent excretion of bilirubin. Most Gilbert’s syndrome patients experience recurrent and short-term episodes of yellowing of the skin and sclera of eyes caused by bilirubin accumulation in the blood. Approximately 30 % of patients with Gilbert's syndrome do not experience any symptoms, but are detected by blood tests that show elevated levels of unconjugated bilirubin. In addition to traditional methods, genetic analysis of the UGT1A1 gene allows us to confirm the diagnosis of Gilbert's syndrome. The article presents modern concepts of the pathogenesis, diagnosis, differential diagnosis and treatment of Gilbert's syndrome. It is of interest to gastroenterologists, internists and general practitioners who treat such patients.
Pathological changes in the gastrointestinal tract in patients with diabetes mellitus
Authors: Aslanov B. I. , Chirkina T. M. , Kokovina Yu. V. , Antonova E. A. , Tiselko A. V. , Shirai O. V. , Ignatova O. K.
Published: January 2023

Autonomic neuropathy in patients with diabetes mellitus (DM) is the leading cause of damage to the digestive tract. As a result of chronic hyperglycemia and high glucose variability, the esophagus, stomach, small intestine, and large intestine are most often affected. The most common disorder of the digestive system in diabetes is gastroparesis. Clinical symptoms of gastroparesis have similarities with other functional disorders of digestive tract, which complicates differential diagnosis with other diseases. Quality of life of these patients is worsened because of significant difficulties in managing postprandial glycemia. Since patients with diabetes are quite often affected by cholelithiasis, this review also considers the need for surgical intervention and the subsequent effect of cholecystectomy on the development of gastroparesis in these patients. It is important to remember that after gallbladder removal patients need more careful monitoring of glucose levels. This will allow timely prescription of antidiabetic therapy and reduce the risk of developing gastroparesis in the future. In addition, the effect of coronavirus infection on functional damage of the digestive tract in patients with diabetes is discussed. A special diet is important in the therapy of gastroparesis. Exclusion of hard-to-digest fiber, fatty foods, inclusion of vitamin complexes and normalization of microbiota contribute to slower glucose absorption after meals and better compensation of disease. The main therapeutic value is the timely diagnosis of gastroparesis and normalization of glucose levels.
MODELING OF OPTICAL CONDUCTIVITY OF NETWORKS WITH FULL BINARY ENCODING
Authors:   Moscow State University for the Humanities, Moscow, Russian Federation, VIKTOROVA  NADEZHDA , OZHIGOV  YURI ,   Lomonosov Moscow State University, Moscow, Russian Federation,   Valiev Institute of Physics and Technology
Published: January 2023

Optical conductivity is the most important characteristic of graphs. It is a special case of continuous quantum walks on a graph and depends both on the structure of the graph and on the characteristics of the waveguides that are its edges. We investigated the conductivity of optical networks whose vertices have binary encoding depending on the thickness and length of the waveguides. It is found that the conductivity drops to zero with increasing graph size at different distributions of waveguide characteristics, which contrasts with random walks on a straight line, where such an effect does not occur. This effect has a purely interference nature and manifests itself precisely for graphs whose encoding contains all binary sets. More subtle dependences of conductivity on the characteristics of waveguides are also established. This result can be useful when choosing the structure of optical nanodevices of large sizes, for example, for optical quantum computers.
APPLICATION OF COMPUTER MATHEMATICS SYSTEMS FOR SOLVING PROBLEMS OF CONTACT GEOMETRY
Authors:   T.F. Gorbachev Kuzbass State Technical University, Kemerovo, Russian Federation, SLAVOLYUBOVA  YAROSLAVNA
Published: January 2023

Task. The development of research in the field of contact geometry is impossible without the use of computer mathematics systems. Carrying out a computational experiment allows not only obtaining numerical results, analytical expressions, but also highlighting the correct and promising direction in obtaining theoretical results. Purpose of the work: to consider the application of computer mathematics systems to solving problems of contact geometry. Achieving the goals set in the work is carried out on the basis of the integrated use of computer algebra methods, mathematical modeling, the theory of differential geometry and tensor analysis. Findings. In this paper, we present schemes for studying contact Lie groups of arbitrary odd dimension. An algorithm and a set of programs have been developed in the Maxima computer mathematics system for modeling the proof of the existence of Sasakian structures. Practical value. This algorithm can be used to study contact structures on homogeneous spaces. The proposed schemes are of scientific and practical interest for specialists in the field of differential geometry and methods of its applications, as well as for solving the problems of developing quantum computing devices.
Comunicación académica: una disciplina que nos conviene impulsar
Authors: Codina Lluís , Morales-Vargas Alejandro , Pedraza Jiménez Rafael , Cortiñas Rovira Sergi
Published: January 2023

Comunicación académica es el nombre que recibe un amplio campo de actividades vinculado con las muy diversas formas en las que los autores de trabajos académicos publican y difunden sus resultados. Incluye tareas cuyas conexiones con esta publicación no solo son directas, sino que se influyen mutuamente. Se trata de las labores de difusión, tratamiento, análisis y recuperación de información, como las que llevan a cabo las bases de datos y otros agentes. Pero la cuestión aún va más lejos y a estas debemos añadir otras actividades, igualmente interconectadas, como la preservación y el aumento de la visibilidad, junto a actuaciones especializadas que realizan las bibliotecas universitarias. Se concluye que la comunicación académica pese a su amplitud y diversidad (o precisamente por ello) debería ser estudiada por una disciplina unificada que, gracias a una visión holística, ayude a superar sus principales problemas. En este trabajo se presentan algunos de estos problemas y se defiende la necesidad de que tanto el ámbito de actividades en sí como la disciplina que las estudia reciban un impulso más claro y decidido.
Reescrituras transmedia del universo Sherlock: de Doyle a la BBC
Authors: Requena Hidalgo Cora Lorena
Published: January 2023

Desde su aparición en el siglo XIX Sherlock Holmes ha sido objeto de un sinnúmero de adaptaciones a múltiples formatos, medios y plataformas que actualizan el personaje, icono y paradigma del investigador independiente. Su incorporación al siglo XXI ha ocasionado una ampliación del universo en un primer momento creado por Arthur Conan Doyle, a través de la aparición de una multiplicidad de autores que bien se han regido por el canon o bien han optado por la interpretación más libre del fandom. Este artículo hace un recorrido breve por ambas tradiciones para luego centrarse en el análisis de las contribuciones que la última producción de la cadena televisiva británica BBC Sherlock (2010-2017) ha aportado al imaginario colectivo en el que se inscriben el personaje y su universo. Especial importancia tienen para este análisis las producciones transmedia para la realización de la serie, así como los cambios que estas han provocado en el tipo de relaciones que el detective establece con su entorno inmediato, tecnológico y humano, que le otorgan una nueva dimensión en sintonía con los nuevos tiempos.
Revistas ‘Open Access’ sobre comunicación. Un mapa mundial
Authors: López del Castillo Wilderbeek Francisco Leslie
Published: January 2023

La publicación en acceso abierto ha demostrado ser un espacio muy beneficioso para todos los actores involucrados en el mundo académico. Sin embargo, persisten opiniones encontradas sobre si en la práctica hay diferencias sobre su posición con respecto las revistas en que se paga por la consulta. Esta investigación se ha propuesto analizar la configuración de las revistas académicas sobre comunicación observando los datos del índice Scimago Journal Rank (SJR) sobre la base de datos Scopus . Concretamente se han intentado encontrar diferencias o similitudes entre las revistas que son de acceso abierto y aquellas que no lo son. Los resultados obtenidos señalan que las revistas de acceso abierto sobre comunicación obtienen una citación y resultados inferiores en los indicadores de calidad. Por otro lado, han permitido relativizar la máxima según la cual los países con menores ingresos económicos apuestan en mayor medida por el modelo de publicación en acceso abierto.
Simposio de la Viruela del Mono (Mpox)
Authors: Maguiña-Vargas Ciro
Published: January 2023

Agradezco al Comité Editorial de la Revista “Diagnóstico” por la invitación a desarrollar un importante simposio sobre una nueva enfermedad infecciosa, la viruela del mono (VM), que en pocos meses desde su aparición, en mayo 2022, ya ha sido declarada por la Organización Mundial de la Salud (OMS) como una  emergencia sanitaria mundial.
Mannan based prebiotics modulate growth rate and energy phenotype of tetracycline resistant E. coli
Authors: Grant Sharon , Smith Helen , Murphy Richard
Published: January 2023

Unsustainable antimicrobial use in industrial agriculture has contributed to the rise in antimicrobial resistance and there is an urgent need to find alternative and more sustainable strategies to traditional antimicrobials. Prebiotics, such as mannan-rich fraction (MRF), a cell wall product from Saccharomyces cerevisiae, have demonstrated an ability to alter the growth of antibiotic susceptible and resistant Escherichia coli and improve the efficacy of antibiotics through modulation of cellular activity. In this study the impact of mannan based prebiotics on growth and respiration of E. coli was assessed by observing microbial growth, oxygen consumption rate and extracellular acidification rate in the presence and absence of tetracycline. The findings further demonstrate the capabilities of MRF with respect to improving microbial antibiotic sensitivity, particularly in resistant strains. This potentially enables a more efficient control of resistant pathogens with food safety implications and promotion of more sustainable use of antibiotics in animal production systems.
Genetic engineering to enhance microalgal-based produced water treatment with emphasis on CRISPR/Cas9: A review
Authors: Hassanien Alaa , Saadaoui Imen , Schipper Kira , Al-Marri Sara , Dalgamouni Tasneem , Aouida Mustapha , Saeed Suhur , Al-Jabri Hareb M.
Published: January 2023

In recent years, the increased demand for and regional variability of available water resources, along with sustainable water supply planning, have driven interest in the reuse of produced water. Reusing produced water can provide important economic, social, and environmental benefits, particularly in water-scarce regions. Therefore, efficient wastewater treatment is a crucial step prior to reuse to meet the requirements for use within the oil and gas industry or by external users. Bioremediation using microalgae has received increased interest as a method for produced water treatment for removing not only major contaminants such as nitrogen and phosphorus, but also heavy metals and hydrocarbons. Some research publications reported nearly 100% removal of total hydrocarbons, total nitrogen, ammonium nitrogen, and iron when using microalgae to treat produced water. Enhancing microalgal removal efficiency as well as growth rate, in the presence of such relevant contaminants is of great interest to many industries to further optimize the process. One novel approach to further enhancing algal capabilities and phytoremediation of wastewater is genetic modification. A comprehensive description of using genetically engineered microalgae for wastewater bioremediation is discussed in this review. This article also reviews random and targeted mutations as a method to alter microalgal traits to produce strains capable of tolerating various stressors related to wastewater. Other methods of genetic engineering are discussed, with sympathy for CRISPR/Cas9 technology. This is accompanied by the opportunities, as well as the challenges of using genetically engineered microalgae for this purpose.
Kinase PLK1 regulates the disassembly of the lateral elements and the assembly of the inner centromere during the diakinesis/metaphase I transition in male mouse meiosis
Authors: Gómez Rocío , Viera Alberto , Moreno-Mármol Tania , Berenguer Inés , Guajardo-Grence Andrea , Tóth Attila , Parra María Teresa , Suja José A.
Published: January 2023

PLK1 is a serine/threonine kinase with crucial roles during mitosis. However, its involvement during mammalian male meiosis remains largely unexplored. By inhibiting the kinase activity of PLK1 using BI 2536 on organotypic cultures of seminiferous tubules, we found that the disassembly of SYCP3 and HORMAD1 from the lateral elements of the synaptonemal complex during diakinesis is impeded. We also found that the normal recruitment of SYCP3 and HORMAD1 to the inner centromere in prometaphase I spermatocytes did not occur. Additionally, we analyzed the participation of PLK1 in the assembly of the inner centromere by studying its implication in the Bub1-H2AT120ph-dependent recruitment of shugoshin SGO2, and the Haspin-H3T3ph-dependent recruitment of Aurora B/C and Borealin. Our results indicated that both pathways are regulated by PLK1. Altogether, our results demonstrate that PLK1 is a master regulator of the late prophase I/metaphase I transition in mouse spermatocytes.
Caloric restriction induced epigenetic effects on aging
Authors: Zhai Jingfang , Kongsberg William H. , Pan Yinbo , Hao Canhua , Wang Xiaojing , Sun Jie
Published: January 2023

Aging is the subject of many studies, facilitating the discovery of many interventions. Epigenetic influences numerous life processes by regulating gene expression and also plays a crucial role in aging regulation. Increasing data suggests that dietary changes can alter epigenetic marks associated with aging. Caloric restriction (CR)is considered an intervention to regulate aging and prolong life span. At present, CR has made some progress by regulating signaling pathways associated with aging as well as the mechanism of action of intercellular signaling molecules against aging. In this review, we will focus on autophagy and epigenetic modifications to elaborate the molecular mechanisms by which CR delays aging by triggering autophagy, epigenetic modifications, and the interaction between the two in caloric restriction. In order to provide new ideas for the study of the mechanism of aging and delaying aging.
Effects of Salvia miltiorrhiza active compounds on placenta-mediated pregnancy complications
Authors: Kong Jingyin , Li Songjun , Li Yingting , Chen Min
Published: January 2023

Placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE), fetal growth restriction (FGR), and recurrent spontaneous abortion (RSA), occur in approximately 5% of pregnancies and are caused by abnormal placenta development. The development of effective therapies for PMPCs is still challenging due to the complicated pathogenesis, such as disrupted vascular homeostasis and subsequent abnormal placentation. Synthetic drugs have been recommended for treating PMPCs; however, they tend to cause adverse reactions in the mother and fetus. Salvia miltiorrhiza (S. miltiorrhiza) has potential effects on PMPCs owing to its advantages in treating cardiovascular disorders. S. miltiorrhiza and its active compounds could attenuate the symptoms of PMPCs through anticoagulation, vasodilation, antioxidation, and endothelial protection. Thus, in this review, we summarize the literature and provide comprehensive insights on S. miltiorrhiza and its phytochemical constituents, pharmacological activities, and on PMPCs, which would be valuable to explore promising drugs.
Towards commercialization of fluorinated cation-disordered rock-salt Li-ion cathodes
Authors: Lee Gi-Hyeok , Lim Jungwoo , Shin Jeongyim , Hardwick Laurence J. , Yang Wanli
Published: January 2023

Cation-disordered rock-salt cathodes (DRX) are promising materials that could deliver high capacities (>250 mAh g−1) with Earth abundant elements and materials. However, their electrochemical performances, other than the capacity, should be improved to be competitive cathodes, and many strategies have been introduced to enhance DRXs. Fluorination has been shown to inhibit oxygen loss and increase power density. Nevertheless, fluorinated cation-disordered rock-salts still suffer from rapid material deterioration and low scalability which limit their practical applications. This mini-review highlights the key challenges for the commercialization of fluorinated cation-disordered rock-salts, discusses the underlying reasons behind material failure and proposes future development directions.
Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds
Authors: Duan Qunpeng , Chen Ran , Deng Su , Yang Cheng , Ji Xinxin , Qi Gege , Li Hui , Li Xiaohan , Chen Shihao , Lou Mengen , Lu Kui
Published: January 2023

The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[n]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.
Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome
Authors: Xiao Qiu-yue , Ye Tian-yuan , Wang Xiao-long , Qi Dong-mei , Cheng Xiao-rui
Published: January 2023

Introduction

Alzheimer’s disease is the most common form of dementia and closely related to aging. Qi-Fu-Yin is widely used to treat dementia, but its anti-aging effects is unknown.

Methods

We used 11-month-old APP/PS1 transgenic mice for behavioral tests to observe the changes in cognitive function and age-related symptoms after Qi-Fu-Yin treatment. Fecal samples were collected for 16sRNA sequencing and metagenomic sequencing. Differences among the groups of intestinal microbiota and the associations with aging and intestinal microbiota were analyzed based on the results.

Results

Here we found that Qi-Fu-Yin improved the ability of motor coordination, raised survival rate and prolonged the survival days under cold stress stimulation in aged APP/ PS1 transgenic mice. Our data from 16sRNA and metagenomic sequencing showed that at the Family level, the intestinal microbiota was significantly different among wild-type mice, APP/PS1 transgenic mice and the Qi-Fu-Yin group by PCA analysis. Importantly, Qi-Fu-Yin improved the functional diversity of the major KEGG pathways, carbohydrate-active enzymes, and major virulence factors in the intestinal flora of APP/PS1 transgenic mice. Among them, the functions of eight carbohydrate-active enzymes (GT2_Glycos_transf_2, GT4, GT41, GH2, CE1, CE10, CE3, and GH24) and the functions of top three virulence factors (defensive virulence factors, offensive virulence factors and nonspecific virulence factors) were significantly and positively correlated with the level of grasping ability. We further indicated that the Qi-Fu-Yin significantly reduced the plasma levels of IL-6.

Conclusion

Our results indicated that the effects of Qi-Fu-Yin anti-aging of APP/PS1 transgenic mice might be through the regulation of intestinal flora diversity, species richness and the function of major active enzymes.
Graph neural networks for decentralized multi-agent perimeter defense
Authors: Lee Elijah S. , Zhou Lifeng , Ribeiro Alejandro , Kumar Vijay
Published: January 2023

In this work, we study the problem of decentralized multi-agent perimeter defense that asks for computing actions for defenders with local perceptions and communications to maximize the capture of intruders. One major challenge for practical implementations is to make perimeter defense strategies scalable for large-scale problem instances. To this end, we leverage graph neural networks (GNNs) to develop an imitation learning framework that learns a mapping from defenders’ local perceptions and their communication graph to their actions. The proposed GNN-based learning network is trained by imitating a centralized expert algorithm such that the learned actions are close to that generated by the expert algorithm. We demonstrate that our proposed network performs closer to the expert algorithm and is superior to other baseline algorithms by capturing more intruders. Our GNN-based network is trained at a small scale and can be generalized to large-scale cases. We run perimeter defense games in scenarios with different team sizes and configurations to demonstrate the performance of the learned network.
Case report: Area of focus in a case of malignant hypertension
Authors: Bosisio Francesca Gaia , Mingardi Desirè , Moretti Elisabetta , Muzi Giorgia , Russomanno Francesco , Tassani Nicola , Stassaldi Deborah , Agabiti Rosei Claudia , De Ciuceis Carolina , Salvetti Massimo , Muiesan Maria Lorenza
Published: January 2023

Malignant hypertension (MH) is characterized by severe hypertension (usually grade 3) associated with fundoscopic changes (flame hemorrhages and/or papilledema), microangiopathy and disseminated intravascular coagulation. In addition encephalopathy, acute heart failure and acute deterioration in renal function may be present. The term “malignant” reflects the very poor prognosis for this condition if untreated. When severe hypertension is associated with hypertension-mediated organ damage (HMOD) a life-threatening situation that requires immediate but careful intervention occurs (hypertensive emergency). In the last few years an increase in the number of patients with malignant hypertension has been observed, especially among those patients with black ethnicity. Limited access to treatment and the poor adherence to anti-hypertensive therapy may contribute to the development of hypertensive emergencies. It is considered appropriate to study patients in order to rule out thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. In fact, the microvascular damage caused by malignant hypertension can favor intravascular hemolysis like Thrombotic Microangiopathies (TMs). TMs may present in three different clinical conditions: typical hemolytic uremic syndrome (HUS), atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP). TMs can arise in the context of other pathological processes, including malignant hypertension.
Estimating the tropical cyclone wind structure using physics-incorporated networks
Authors: Yuan Shijin , You Qianhu , Mu Bin , Qin Bo , Xu Jing
Published: January 2023

Satellite-based remote sensing technology plays a significant role in identifying tropical cyclones (TCs), and most of the current research focuses on intensity estimation. However, analyzing the wind structure of TCs, which is directly related to the danger they bring, remains a challenge. By adding prior knowledge of TCs into the model, we propose a physics-incorporated network based on multi-task learning to estimate wind radii and intensity, whose layers can automatically extract rotation-invariant features related to the TC core from multichannel satellite imageries. In addition, we build a more comprehensive dataset, including global Statistical Hurricane Intensity Prediction Scheme (SHIPS) predictors, to tackle the structure task. We compare our model with existing methods, and it shows that our model gets better results in estimating 50-knot and 64-knot wind radii and achieves a 4.87-knot root-mean-squared error (RMSE) of intensity. By predicting probability density functions, our model quantifies the uncertainty of the result. The experimental results show that the incorporation of rotation equivariance into the layers can enhance TC structure estimation. By considering the feature importance of multi-source predictors, we find that our model pays attention to key predictors related to the TC structure. Specifically, the tangential wind speed at 500 km from the TC center and the radius of the 5-knot wind both greatly reduce the error of the estimated parameters. Finally, two case studies show that the proposed model performs well most of the time during TCs’ rapid intensification. However, when TCs’ system is not well organized, estimating the wind structure is challenging.
The evolution characteristics of diamondoids in coal measures and their potential application in maturity evaluation
Authors: Zhai Jia , Cao Zhenglin , Fang Chenchen , Yuan Yilin , Wu Wei , Liu Jinzhong
Published: January 2023

In this study, gold tube thermal simulation experiments were carried out on the soluble components (extracts) and insoluble components (extracted coal-measure mudstones) of coal-measure mudstones, and diamondoid compounds in the pyrolysis products were quantitatively analyzed. The results showed that diamondoid compounds in the extracts and the extracted coal-measure mudstones had undergone the process of formation and decomposition during thermal evolution. Based on the quantitative composition of the extracts and the extracted coal-measure mudstones, the calculated evolution characteristics of the diamondoid compounds in the coal-measure mudstones were mainly consistent with the results of thermal simulation experiments, indicating that the formation of diamondoid compounds was primarily controlled by the original material source. Some diamondoid maturity parameters (MAI, EAI, TMAI-1) in coal-measure mudstones were consistent with the parameters of the evolution characteristics in marine shale. Therefore, the relationship between these parameters and vitrinite reflectance can be established, to calculate the maturity of marine source rocks. In addition, the evolution characteristics and some diamondoid maturity parameters in the extracts and the extracted coal- measure mudstones showed a good linear relationship, but the specific characteristics were different, which may enable the identification of kerogen cracking and secondary cracking of crude oil.
Dynamic optimization of open-pit coal mine production scheduling based on ARIMA and fuzzy structured element
Authors: Liu Guangwei , Guo Weiqiang , Fu Ensan , Yang Chuanda , Li Jiaming
Published: January 2023

A dynamic optimization method was created to address the production schedule issue in an open-pit coal mine while taking into account the characteristics of the fuzzy structured element. The fuzzy mining capacities of all “geologically optimal push-back bodies” were then examined using the moving cove method. One of the most crucial elements in the process of open-pit coal mine production scheduling optimization is coal pricing. As a result, this work also presents a dynamic optimization technique for production scheduling that incorporates the prediction of economic time series and the generation of dynamic economic indices. An appropriate time series model is created to forecast the future coal price based on previous data on coal prices. The prediction results are used in the calculation of optimal mining body generation to dynamically obtain the optimal production scheduling model. The Baorixile Open-pit Coal Mine in China’s Inner Mongolia Autonomous Region is using this method. The Autoregressive Integrated Moving Average Model ARIMA is constructed to anticipate the coal price in the future 23 years by evaluating and processing the coal price from 2009 to 2022, and the ideal production scheduling scheme of the mine economics is afterwards identified. The ideal fuzzy coal mining volume, the potential production life, and the fuzzy total net present value (NPV) of the annual production scheduling are all provided at the same time. The optimization findings can better give fundamental support for mine design and future production since the fuzzy problem is accurately expressed by correct formulations.