bluuebunny/crossref_metadata_2025 huggingface dataset:
131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment
Authors: D'Huyvetter Matthias , De Vos Jens , Xavier Catarina , Pruszynski Marek , Sterckx Yann G.J. , Massa Sam , Raes Geert , Caveliers Vicky , Zalutsky Michael R. , Lahoutte Tony , Devoogdt Nick
Published: July 2017

Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-targeted therapy. Here, we describe the generation of a 131I-labeled sdAb as a theranostic drug to treat HER2-overexpressing cancer.

Experimental Design: Anti-HER2 sdAb 2Rs15d was labeled with 131I using [131I]SGMIB and evaluated in vitro. Biodistribution was evaluated in two HER2+ murine xenograft models by micro-SPECT/CT imaging and at necropsy, and under challenge with trastuzumab and pertuzumab. The therapeutic potential of [131I]SGMIB-2Rs15d was investigated in two HER2+ tumor mouse models. A single-dose toxicity study was performed in mice using unlabeled [127I]SGMIB-sdAb at 1.4 mg/kg. The structure of the 2Rs15d–HER2 complex was determined by X-ray crystallography.

Results: [131I]SGMIB-2Rs15d bound specifically to HER2+ cells (Kd = 4.74 ± 0.39 nmol/L). High and specific tumor uptake was observed in both BT474/M1 and SKOV-3 tumor xenografted mice and surpassed kidney levels by 3 hours. Extremely low uptake values were observed in other normal tissues at all time points. The crystal structure revealed that 2Rs15d recognizes HER2 Domain 1, consistent with the lack of competition with trastuzumab and pertuzumab observed in vivo. [131I]SGMIB-2Rs15d alone, or in combination with trastuzumab, extended median survival significantly. No toxicity was observed after injecting [127I]SGMIB-2Rs15d.

Conclusions: These findings demonstrate the theranostic potential of [131I]SGMIB-2Rs15d. An initial scan using low radioactive [*I]SGMIB-2Rs15d allows patient selection and dosimetry calculations for subsequent therapeutic [131I]SGMIB-2Rs15d and could thereby impact therapy outcome on HER2+ breast cancer patients. Clin Cancer Res; 23(21); 6616–28. ©2017 AACR.
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer
Authors: Formisano Luigi , Stauffer Kimberly M. , Young Christian D. , Bhola Neil E. , Guerrero-Zotano Angel L. , Jansen Valerie M. , Estrada Mónica M. , Hutchinson Katherine E. , Giltnane Jennifer M. , Schwarz Luis J. , Lu Yao , Balko Justin M. , Deas Olivier , Cairo Stefano , Judde Jean-Gabriel , Mayer Ingrid A. , Sanders Melinda , Dugger Teresa C. , Bianco Roberto , Stricker Thomas , Arteaga Carlos L.
Published: July 2017

Purpose: FGFR1 amplification occurs in approximately 15% of estrogen receptor–positive (ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer.

Experimental Design: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 IHC, FGFR1 FISH, and RNA sequencing (RNA-seq). ER+/FGFR1–amplified breast cancer cells, and patient-derived xenografts (PDX) were treated with FGFR1 siRNA or the FGFR tyrosine kinase inhibitor lucitanib. Endpoints were cell/xenograft growth, FGFR1/ERα association by coimmunoprecipitation and proximity ligation, ER genomic activity by ChIP sequencing, and gene expression by RT-PCR.

Results: ER+/FGFR1–amplified tumors in patients treated with letrozole maintained cell proliferation (Ki67). Estrogen deprivation increased total and nuclear FGFR1 and FGF ligands expression in ER+/FGFR1–amplified primary tumors and breast cancer cells. In estrogen-free conditions, FGFR1 associated with ERα in tumor cell nuclei and regulated the transcription of ER-dependent genes. This association was inhibited by a kinase-dead FGFR1 mutant and by treatment with lucitanib. ChIP-seq analysis of estrogen-deprived ER+/FGFR1–amplified cells showed binding of FGFR1 and ERα to DNA. Treatment with fulvestrant and/or lucitanib reduced FGFR1 and ERα binding to DNA. RNA-seq data from FGFR1-amplified patients' tumors treated with letrozole showed enrichment of estrogen response and E2F target genes. Finally, growth of ER+/FGFR1–amplified cells and PDXs was more potently inhibited by fulvestrant and lucitanib combined than each drug alone.

Conclusions: These data suggest the ERα pathway remains active in estrogen-deprived ER+/FGFR1–amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR antagonists. Clin Cancer Res; 23(20); 6138–50. ©2017 AACR.
Downregulation of Cavin‐1 Expression via Increasing Caveolin‐1 Degradation Prompts the Proliferation and Migration of Vascular Smooth Muscle Cells in Balloon Injury–Induced Neointimal Hyperplasia
Authors: Zhou Li‐Jun , Chen Xue‐Ying , Liu Shui‐Ping , Zhang Lin‐Lin , Xu Ya‐Nan , Mu Pan‐Wei , Geng Deng‐Feng , Tan Zhi
Published: July 2017

Background

Percutaneous coronary intervention has been widely used in the treatment of ischemic heart disease, but vascular restenosis is a main limitation of percutaneous coronary intervention. Our previous work reported that caveolin‐1 had a key functional role in intimal hyperplasia, whereas whether Cavin‐1 (another important caveolae‐related protein) was involved is still unknown. Therefore, we will investigate the effect of Cavin‐1 on neointimal formation.

Methods and Results

Balloon injury markedly reduced Cavin‐1 protein and enhanced ubiquitin protein expression accompanied with neointimal hyperplasia in injured carotid arteries, whereas Cavin‐1
mRNA
had no change. In cultured vascular smooth muscle cells (
VSMC
s), Cavin‐1 was downregulated after inhibition of protein synthesis by cycloheximide, which was distinctly prevented by pretreatment with proteasome inhibitor
MG
132 but not by lysosomal inhibitor chloroquine, suggesting that proteasomal degradation resulted in Cavin‐1 downregulation. Knockdown of Cavin‐1 by local injection of Cavin‐1 short hairpin RNA (shRNA) into balloon‐injured carotid arteries in vivo promoted neointimal formation. In addition, inhibition or overexpression of Cavin‐1 in cultured
VSMC
s in vitro prompted or suppressed
VSMC
proliferation and migration via increasing or decreasing extracellular signal‐regulated kinase phosphorylation and matrix‐degrading metalloproteinases‐9 activity, respectively. However, under basic conditions, the effect of Cavin‐1 on
VSMC
migration was stronger than on proliferation. Moreover, our results indicated that Cavin‐1 regulated caveolin‐1 expression via lysosomal degradation pathway.

Conclusions

Our study revealed the role and the mechanisms of Cavin‐1 downregulation in neointimal formation by promoting
VSMC
proliferation, migration, and synchronously enhancing caveolin‐1 lysosomal degradation. Cavin‐1 may be a potential therapeutic target for the treatment of postinjury vascular remodeling.
What Can South-South Development Cooperation Do for International Peace? Brazil’s Role in Haiti and Guinea-Bissau
Authors: Abdenur Adriana Erthal
Published: July 2017

Until it began waning due to economic crisis and political turmoil on the domestic front, in Brazil’s rapidly expanding South-South development, cooperation often has been promoted by government officials as contributing to stability and prosperity in partner states. It is unclear, however, how this development cooperation intersects with the country’s involvement inunpeace operations. This article examines the role of Brazilian South-South technical cooperation across two contexts. In Haiti, Brazil has led the military component of theminustah, whereas in Guinea-Bissau, it has helped to spearhead peacebuilding efforts by the international community. In both cases, Brazil has tried to substantiate its critique of theun’s securitization by providing technical cooperation across a variety of sectors. The analysis shows that this cooperation is too fragmented, subject to interruptions, and disconnected fromun-led efforts to make a considerable contribution to a sustainable peace. However, better internal coordination and stronger ties touninitiatives could boost the contribution of Brazil’s Brazilian South-South development cooperation to a lasting peace.
Cladistic analysis of the Zethus (Zethoides) (Hymenoptera, Vespidae, Eumeninae) species groups with insights on the current subgeneric classification of Zethus Fabricius, 1804
Authors: Lopes Rogério Botion , Noll Fernando Barbosa
Published: July 2017

Zethus is the largest genus in Eumeninae, with over 250 species. Currently, it is divided in four subgenera: Z. (Zethus), Z. (Zethusculus), Z. (Zethoides) and Z. (Madecazethus). Z. (Zethoides), with 42 species, is subdivided in eight species groups, each considered a phylogenetic unit, that were created without any phylogenetic analysis. Eighteen species of Z. (Zethoides) corresponding to different groups were examined, altogether with terminals from distinct lineages of Zethus, Zethini and Eumenini, to perform a cladistics analysis to verify the proposed divisions. Zethus (Zethoides) and all of its species groups, except for the Z. biglumis group, were monophyletic. Zethus s.s. was paraphyletic in relation to Z. (Madecazethus), Z. (Zethoides) and Ctenochilus. Z. (Zethusculus) was also retrieved paraphyletic. Despite the subgeneric incongruences, the outgroups were too poorly represented to carry a taxonomic modification. Thus, the only alteration was the inclusion of the Z. clypearis group in the Z. biglumis group.
Three new species of Pristimantis (Amphibia, Anura, Craugastoridae) from upper montane forests and high Andean grasslands of the Pui Pui Protected Forest in central Peru
Authors: LEHR EDGAR , MAY RUDOLF VON , MORAVEC JIŘÍ , CUSI JUAN CARLOS
Published: July 2017

We describe three new species of Pristimantis from the upper montane forests and high Andean grasslands of the Pui Pui Protected Forest and its close surroundings (Región Junín, central Peru) and compare them morphologically and genetically with other taxonomically and biogeographically relevant species of Pristimantis. All three new species have the skin on dorsum shagreen with scattered tubercles, discontinuous dorsolateral folds, tuberculate flanks, and the skin on venter areolate. Pristimantis bounides sp. nov. is known from two localities outside the Pui Pui Protected Forest in upper montane forests between 3350 and 3463 m a.s.l. and is characterized by a snout–vent length of 18.2–21.0 mm in males (n = 3), and 21.6–24.4 mm in females (n = 4), by having a tympanum, males with vocal slits, and discs of digits slightly expanded with circumferential grooves. In life, dorsal and lateral ground coloration is pale grayish brown, orange brown, yellowish brown or reddish brown with dark grayish-brown marmorations, and a pale gray, pale greenish gray or creamish white venter with or without dark gray mottling. Pristimantis humboldti sp. nov. is known from one locality inside the Pui Pui Protected Forest, in upper montane forest at 3318 m a.s.l., and is characterized by a snout–vent length of 17.2–20.6 mm in males (n = 3), and 19.7–25.7 mm in females (n = 6), by having a tympanum, males with vocal slits, and discs of digits expanded with circumferential grooves. In life, dorsal and lateral ground coloration is orange brown with brownish-olive blotches, orange brown with grayish-brown blotches and flecks, reddish brown with grayish-brown blotches or grayish brown with orange brown blotches; throat, chest, belly, anterior and ventral surfaces of thighs, tibia, and axilla are dark gray and pale gray mottled with white and pale gray spots of different sizes and density. Pristimantis puipui sp. nov. is known from one locality inside the Pui Pui Protected Forest, in the puna at 3890 m a.s.l., and is characterized by a snout–vent length of 16.1–17.1 mm in males (n = 3), and 20.6–22.4 mm in females (n = 4), by lacking a tympanum, lacking males with vocal slits, and tips of digits narrow without circumferential grooves. In life, dorsal and lateral ground coloration is pale orange brown, reddish brown or grayish brown with or without grayish-brown mottling, and the venter is pale cream and pale gray mottled. A molecular phylogenetic analysis based on mitochondrial and nuclear DNA sequences inferred that the three new species belong to the Pristimantis danae species Group distributed in the montane forests and high Andean grasslands of central Peru, including P. albertus, P. aniptopalmatus, P. ornatus, and P. stictogaster. With the three new species, 133 species of Pristimantis are currently known from Peru, eight of which inhabit the puna.
The Gomphocerinae Tarbinsky, 1932 (Orthoptera: Acrididae) fauna of the Turkish Thrace
Authors: ŞİRİN DENİZ , MOL ABBAS , TAYLAN MEHMET SAÝT , DEMÝR EYÜP , KIZILOCAK DÝLAN HEVRA
Published: July 2017

Fifteen taxa belonging to nine genera (Arcyptera, Ramburiellla, Dociostaurus, Notostaurus, Omocestus, Stenobothrus, Euchorthippus, Pseudochorthippus and Chorthippus) of Gomphocerinae (Orthoptera: Acrididae) were sampled during field trips throughout the different ranges of Turkish Thrace between the years of 2010 and 2015. Bioacoustic parameters of these 15 species have been described for the first time from Turkish Thrace with this study. A total of 5 taxa (Arcyptera (Pararcyptera) microptera microptera, Omocestus (Dirshius) petraeus, Stenobothrus eurasius eurasius, Euchorthippus declivus and C. (Glyptobothrus) biguttulus euhedickei) were identified in the Turkish Thrace region as new records. In addition to these, Stenobothrus eurasius eurasius has been given a new record for Turkey.
A new deep-sea species of the caridean genus Bresilia Calman, 1896 (Crustacea: Decapoda: Bresiliidae) from Sagami Bay, central Japan
Authors: KOMAI TOMOYUKI , KOHTSUKA HISANORI
Published: July 2017

A new species of the rare caridean genus Bresilia Calman, 1896, B. cinctus, is described and illustrated on the basis of a single ovigerous female specimen collected from Sagami Bay, central Japan, at 218–318 m depth. The new species is morphologically most similar to B. rufioculus Komai & Yamada, 2011, known only from shallow water cave of Ie Island (depths 14–17 m), Okinawa Islands, Ryukyu Islands, but many characters, including the proportionally shorter rostrum, the well developed suborbital lobe of the carapace, and the presence of a spiniform seta on the ventral surface of the pereopod 1 palm, immediately distinguish the new species from B. rufioculus. Bresilia cinctus n. sp. is the first species of the genus known from the Japanese main islands. The discovery of the new species led us to reassess the merit of the informal division of Bresilia proposed by Komai & Yamada (2010). An identification key to the ten named species of Bresilia is presented.
Taxonomic review of the species of Andrenosoma (Diptera: Asilidae) in Spain and description of a new species
Authors: GARCÍA MARTA , PÉREZ GUILLERMO , PORTILLO MANUEL
Published: July 2017

Currently, only two species of Andrenosoma are listed from Spain: A. albibarbe (Meigen) and A. atrum (Linnaeus). Here we add three additional species to Spanish list. A. bayardi Séguy, A. cyrtoxys Séguy and A. biacuminatum n.sp. The new species is described and identification key to the Andrenosoma species of Spain is given, as well as new information on the biology and distribution of the genus in Spain.
Space–Time Scales of Shear in the North Pacific
Authors: Alford Matthew H. , MacKinnon Jennifer A. , Pinkel Robert , Klymak Jody M.
Published: July 2017

The spatial, temporal, and directional characteristics of shear are examined in the upper 1400 m of the North Pacific during late spring with an array of five profiling moorings deployed from 25° to 37°N (1330 km) and simultaneous shipboard transects past them. The array extended from a regime of moderate wind generation at the north to south of the critical latitude 28.8°N, where parametric subharmonic instability (PSI) can transfer energy from semidiurnal tides to near-inertial motions. Analyses are done in an isopycnal-following frame to minimize contamination by Doppler shifting. Approximately 60% of RMS shear at vertical scales >20m (and 80% for vertical scales >80 m) is contained in near-inertial motions. An inertial back-rotation technique is used to index shipboard observations to a common time and to compute integral time scales of the shear layers. Persistence times are O(7) days at most moorings but O(25) days at the critical latitude. Simultaneous shipboard transects show that these shear layers can have lateral scales ≥100 km. Layers tend to slope downward toward the equator north of the critical latitude and are more flat to its south. Phase between shear and strain is used to infer lateral propagation direction. Upgoing waves are everywhere laterally isotropic. Downgoing waves propagate predominantly equatorward north and south of the critical latitude but are isotropic near it. Broadly, results are consistent with wind generation north of the critical latitude and PSI near it—and suggest a more persistent and laterally coherent near-inertial wave field than previously thought.
Increasing HPV Vaccination Coverage Through Provider-Based Interventions
Authors: Krantz Landon , Ollberding Nicholas J. , Beck Andrew F. , Carol Burkhardt Mary
Published: July 2017

With discouragingly low vaccination rates for human papillomavirus (HPV), we sought to improve the HPV vaccine completion rate for adolescents by increasing the consistency and quality of provider recommendations. Baseline data was extracted for vaccine completion rates among patients aged 13 to 17 years. Quality improvement measures led to interventions targeting factors associated with vaccine noncompletion, in particular, weaknesses in provider recommendations and patient characteristics most strongly correlated with missed vaccination opportunities. Vaccine completion rates increased overall from 50.9% to 61.7% ( P < .05), an increase seen in both males (42.6% to 57.3%, P < .001) and females (60.0% to 66.5%, P = .04). One-dose rates improved to 88.4% for males ( P = .02) and 91.5% for females ( P = .43). Vaccination also occurred more consistently, increasing from 77.5% of visits (95% CI 71.2-83.0) before study onset to 90.9% of visits (95% CI 85.4%-94.8%) afterward ( P < .01). HPV vaccination rates can increase through focused provider-level prompts and by offering the vaccine consistently.
Ritratti di donne bellissime: Giovanna d’Aragona nel De pulchro di Agostino Nifo
Authors: Morosini Roberta
Published: July 2017

La nota individua la fonte, fino ad ora sconosciuta, di un capitolo del De pulchro di Agostino Nifo (c.1469–c.1546) nell’ Officina di Ravisio Testore. È un catalogo di “donne bellissime” che ha una funzione esemplificativa della tesi principale del trattato filosofico sul bello.
Lay Listener Classification and Evaluation of Typical and Atypical Children’s Speech
Authors: Redford Melissa A. , Kapatsinski Vsevolod , Cornell-Fabiano Jolynn
Published: July 2017

Verbal children with autism spectrum disorder (ASD) often also have atypical speech. In the context of the many challenges associated with ASD, do speech sound pattern differences really matter? The current study addressed this question. Structured spontaneous speech was elicited from 34 children: 17 with ASD, whose clinicians reported unusual speech prosody; and 17 typically-developing, age-matched controls. Multiword utterances were excerpted from each child’s speech sample and presented to young adult listeners, who had no clinical training or experience. In Experiment 1, listeners classified band pass filtered and unaltered excerpts as “typical” or “disordered”. Children with ASD were only distinguished from typical children based on unaltered speech, but the analyses indicated unique contributions from speech sound patterns. In Experiment 2, listeners provided likeability ratings on the filtered and unaltered excerpts. Again, lay listeners only distinguished children with ASD from their typically-developing peers based on unaltered speech, with typical children rated as more likeable than children with ASD. In Experiment 3, listeners evaluated the unaltered speech along several perceptual dimensions. High overlap between the dimensions of articulation, clearness, and fluency was captured by an emergent dimension: intelligibility. This dimension predicted listeners’ likeability ratings nearly as well as it predicted their judgments of disorder. Overall, the results show that lay listeners can distinguish atypical from typical children outside the social-interactional context based solely on speech, and that they attend to speech intelligibility to do this. Poor intelligibility also contributes to listeners’ negative social evaluation of children, and so merits assessment and remediation.
An optimized co-formulation minimized quaternary ammonium compounds adsorption onto raw cotton disposable disinfecting wipes and maintained efficacy against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, and Pseudomonas aeruginosa
Authors: Hinchliffe DJ , Condon BD , Madison CA , Reynolds M , Hron RJ
Published: July 2017

The transmission of infectious agents can occur through secondary routes by contact with contaminated inanimate objects in clinical and food service settings. Effective disinfection of exposed surfaces can aid in reducing secondary transmission of infectious agents. Quaternary ammonium compounds (quats) are biocides widely used as active ingredients in disinfecting solutions and are effective against a wide range of microorganisms, including those with antibiotic resistance. Cellulosic fibers such as cotton are desirable as disposable substrates for the application of disinfecting solutions, since they have good absorbency and cleaning properties and are sustainable and biodegradable. However, cotton fibers deplete quats from solution through strong ionic interactions at the solid–liquid interface, thereby reducing the amount of quat deposited onto a surface for effective disinfection. In this study, we used response surface methodology to model the depletion of the quat, alkyldimethylbenzylammonium chloride (ADBAC), onto cotton wipe substrates in the presence of chemical compounds that interfered or competed with the ionic interactions between the quat and the cotton fiber surface. Preliminary efficacy testing successfully demonstrated that an optimized disinfecting ADBAC co-formulation applied with a raw cotton disposable wipe maintained efficacy against representative gram negative ( Pseudomonas aeruginosa) and gram positive ( Staphylococcus aureus) bacteria compared to a control disinfecting solution containing only ADBAC. Our optimized disinfecting ADBAC co-formulation remained efficacious against Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecalis, demonstrating for the first time that quat adsorption onto cotton substrates can be minimized and efficacy maintained with inexpensive added chemistries.
Textile qualities of regenerated cellulose fibers from cotton waste pulp
Authors: Björquist Stina , Aronsson Julia , Henriksson Gunnar , Persson Anders
Published: July 2017

Cotton is not the answer to meet the rapidly growing demand for textile fibers. Wood-based regenerated cellulose fibers are an attractive alternative. Since wood is a candidate to replace fossil raw materials in so many applications of the circular economy, other sources need investigation. Cotton linters work in the viscose process – can cotton waste be used to make dissolving pulp? We describe the textile qualities of lyocell fibers from (i) pure cotton waste pulp and (ii) blending with conventional dissolving pulp. The staple fibers were tensile tested, yarns spun and tensile tested and knitted, and tested for shrinkage, water and dye sorption, abrasion resistance, fuzzing and pilling, staining and fastness. TENCEL® staple fibers and off-the-shelf TENCEL® yarn were used as references. The results show that the two study fibers had tenacity and an E-modulus that exceeded the staple fiber reference. Also, the study yarns were at least as good as the spun reference yarn and the commercial off-the-shelf yarn in terms of wet tenacity. Single jerseys made from the study yarns shrunk less upon laundering, which is surprising since they could absorb at least as much water at a comparable rate as the references. Dyeability, staining and color fastness, durability and pilling tendency showed that the two study fiber tricots performed at least as good as the references. This study suggests that cotton waste is a promising candidate for special grade pulp to suit niche regenerated fiber products or to spice up conventional wood-based dissolving pulp.
2017 National Standards for Diabetes Self-Management Education and Support
Authors: Beck Joni , Greenwood Deborah A. , Blanton Lori , Bollinger Sandra T. , Butcher Marcene K. , Condon Jo Ellen , Cypress Marjorie , Faulkner Priscilla , Fischl Amy Hess , Francis Theresa , Kolb Leslie E. , Lavin-Tompkins Jodi M. , MacLeod Janice , Maryniuk Melinda , Mensing Carolé , Orzeck Eric A. , Pope David D. , Pulizzi Jodi L. , Reed Ardis A. , Rhinehart Andrew S. , Siminerio Linda , Wang Jing
Published: July 2017

Purpose

The purpose of this study is to review the literature for Diabetes Self-Management Education and Support (DSMES) to ensure the National Standards for DSMES (Standards) align with current evidence-based practices and utilization trends.

Methods

The 10 Standards were divided among 20 interdisciplinary workgroup members. Members searched the current research for diabetes education and support, behavioral health, clinical, health care environment, technical, reimbursement, and business practice for the strongest evidence that guided the Standards revision.

Results

Diabetes Self-Management Education and Support facilitates the knowledge, skills, and ability necessary for diabetes self-care as well as activities that assist a person in implementing and sustaining the behaviors needed to manage their condition on an ongoing basis. The evidence indicates that health care providers and people affected by diabetes are embracing technology, and this is having a positive impact of DSMES access, utilization, and outcomes.

Conclusion

Quality DSMES continues to be a critical element of care for all people with diabetes. The DSMES services must be individualized and guided by the concerns, preferences, and needs of the person affected by diabetes. Even with the abundance of evidence supporting the benefits of DSMES, it continues to be underutilized, but as with other health care services, technology is changing the way DSMES is delivered and utilized with positive outcomes.
Intergenerational Transmission of Sociability: The Mediating Role of Maternal Competence and Maternal Child-Centrism
Authors: Lavenda Osnat , Kestler-Peleg Miri
Published: July 2017

This study focuses on the psychological mechanisms of mothering involved in the association of maternal sociability and the sociability of their preschool children. In particular, it is posited that this association is mediated by two maternal psychological conceptualizations: (a) perception of ability to take on the role of motherhood (i.e., maternal competence) and (b) perception of distribution of resources between child and self (i.e., maternal child-centrism). Participants included 320 Jewish–Israeli mothers of preschool children (age 4-6 years) who completed self-reported questionnaires dealing with social relationships, child sociability, maternal competence, and maternal child-centrism. Multiple regression analyses confirmed the mediating effect of maternal competence and child-centrism as well as the association between the mother’s sociability and child sociability. These findings are discussed in light of social capital theory and contemporary parenting styles. Professionals working with families should be aware of the impact of social networks on maternal perception and their influence on children.
Bataille and the Sociology of Abundance: Reassessing Gifts, Debt and Economic Excess
Authors: McGoey Linsey
Published: July 2017

Over the past 70 years, the sociological and economic study of economic abundance has been side-lined in comparison to the study of economic scarcity. This article calls for a revitalization of the study of abundance through a focus on the writing of Georges Bataille. I point out a number of parallels between Bataille and the work of two economists who are rarely associated with Bataille: John Maynard Keynes and Yanis Varoufakis. My argument is two-fold. Firstly, I argue that Bataille, Keynes and Varoufakis make remarkably similar and under-examined points about the need for sovereign nations to deliberately restrict their own trade surpluses. Secondly, drawing on the anthropologist Marcel Mauss’s writing on sovereign debt forgiveness, I raise new insights about the compatibility of Keynes, Bataille and Mauss’s work. In conclusion, I argue that rejuvenating the study of economic abundance will help to better theorize the limits of mainstream economic thought and the political structures it supports.
The Politics of Religious Fervour: New Considerations on Georges Bataille and Religion
Authors: Brennan Eugene
Published: July 2017

The recent publication of a new translation of On Nietzsche invites renewed consideration of one of Georges Bataille’s most intriguing and complex texts. This work was originally situated within La Somme athéologique, Bataille’s unfinished project for a set of texts exploring the paradoxes of religious atheism. These texts are often consumed with a religious fervour and seem far from the explicitly political considerations of Bataille’s anti-fascist texts in the 1930s, or from the more measured analytical tone of The Accursed Share. However, as some critics have suggested, these texts have a political significance of their own. This review essay will thus consider the tensions between Bataillean perspectives which put more weight on either the ‘political’ or the ‘religious’ as modes of analysis. It begins with an analysis of On Nietzsche before moving to a broader thematic discussion of religion in several recently published texts related to Bataille. The central question posed in the latter half of the article is the following: how can Bataille’s thought be deployed to theorize the religiosity of contemporary capitalism?
Partial slip under complete contacts near adjacent corners
Authors: Balasubramanian Arun , Hills David
Published: July 2017

A solution has been derived for a particular case of complete contact, where the contact edge is located near to an adjacent internal corner and separated by a finite clearance. If the separation is extremely small, the gap may be thought of as a crack and, further, if the contact edge is known to be in a stuck state the classical semi-infinite crack eigensolution will define the tractions along the adjacent contact interface, and hence define the minimum coefficient of friction to ensure adhesion. For problems where this separation is small and finite, the proposed semi-infinite solution defines the tractions along the interface considering the presence of adjacent material. A finite example problem of the block resting in an elastically similar rectangular trench is considered. The solution is then applied to predict the state of edge closure and slip at various finite separations and loading conditions.
Experimental and numerical investigation of through-thickness residual stress of laser-bent Ti samples
Authors: Kotobi Mahdi , Honarpisheh Mohammad
Published: July 2017

One of the important parameters that can influence on performance of a part and its life is residual stress. All manufacturing processes can create residual stress in different ranges. Laser bending is one of the thermoforming processes that has been used in different industries. The aim of this study is investigation of through-thickness residual stress profile of Grade 2 titanium samples that were subjected to laser bending process. Slitting method was used to measure the residual stress profile experimentally. Both series expansion and pulse-regularization methods that are common computational techniques in the slitting method were employed to calculate the residual stress. Besides, finite element simulation of the laser bending process was done to study the through-depth residual stress distribution numerically. The results of two computational techniques were compared to each other and with the finite element method results. Furthermore, the effect of laser bending process on surface roughness and microhardness of the samples at the heat-affected zone was investigated. The results showed that laser bending process can induce considerable residual stress in the heat-affected zone of the part. Comparing the experimental and finite element method results showed good agreement between them. In comparison with the control sample, both surface roughness and microhardness of the samples increased after the laser bending process.
Development and characterization of antibacterial braided polyamide suture coated with chitosan-citric acid biopolymer
Authors: Debbabi Faten , Gargoubi Sondes , Hadj Ayed Mohamed Adnene , Abdessalem Saber Ben
Published: July 2017

Braided polyamide sutures are frequently used in dermatologic surgery for wound closure. However, braided sutures promote bacteria proliferation. In order to prevent wound complications due to this effect, antibacterial sutures should be used. The main objective of this study is the development of new non-absorbable antibacterial polyamide braided suture. This paper suggests new coating process that leads to obtain suture uniformly covered by antibacterial film enclosing chitosan, which is known for its antibacterial benefit. Mechanical properties and surface morphology of developed sutures were investigated by using mechanical tests. Sutures surfaces were also examined by scanning electron microscope, to perceive spreading of coating product on suture surface. In order to identify potential reactions between chemical compounds present in coating solution and suture material, sutures were analyzed by ATR-IF spectroscopy. It has been demonstrated that many eventual bonds between compounds present in coating solutions and polyamide macromolecular chain may occur. The existence of these bonds implies the fixation of biopolymer coating on suture surface. It has been demonstrated that uniform surface may be obtained by progressively applying coating solution containing little amount of chitosan on suture surface. We have also found that developed coating process has not affected mechanical properties of suture, which still meet United States Pharmacopeia requirement. Finally, antibacterial effects against four colonies, very widespread in hospitals, were studied. Prominent antibacterial effects of braided polyamide suture against two gram-positive ( S Aureus, S epidermidis) and two gram-negative ( E coli and P aeruginosa) colonies are presented. Optimal result of best properties is obtained by applying three layers of biopolymer coating comprising 1% chitosan and 10% citric acid. The new developed suture coating process appears as a promising method for obtaining important antibacterial effect with smooth suture surface.
Modelling and experimental studies on a proportional valve using an innovative dynamic flow-rate measurement in fluid power systems
Authors: Ferrari Alessandro , Pizzo Pietro , Rundo Massimo
Published: July 2017

A numerical model of a servoactuator and of a four-port proportional direction control valve has been developed. Mechanical and hydraulic elements have been simulated in the LMS Amesim® environment. The complete model has been validated on the basis of the experimental time histories of the actuator velocity and of the flow-rate controlled by the proportional valve. The validation data have been acquired on a fluid power system used to test electro-hydraulic servovalves according to ISO 10770-1 standard. The measurement of the instantaneous flow-rate through the valve has been performed with an innovative high-dynamics flowmeter, recently developed for high-pressure liquid flows. Furthermore, the model predicted static characteristic of the proportional valve has been compared with a corresponding experimentally derived curve and an analysis of the cause-and-effect relationships has been carried out for the valve static performance. Measured data on valve leakages have also been presented in order to complete the steady-state characterization of the tested valve. The developed model of the hydraulic system has been then applied to realize the Bode diagram of the proportional valve, which is expressed in terms of instantaneous flow-rate as a function of the sinusoidal driving command, as well as the Bode diagram of the subsystem made up of the proportional valve and of the linear actuator. The latter Bode graph is plotted in terms of piston velocity as a function of the sinusoidal driving command provided to the valve. The comparison between the two Bode diagrams has confirmed the accuracy of the ISO procedure, which is based on the assumption of negligible delay introduced by the dynamic response of the servo-actuator and by the oil compressibility. A reliable and cost-saving methodology, which uses the innovative flowmeter instead of the low inertia servo-actuator, is proposed as an alternative to the ISO standard for testing the dynamic response of proportional valves.
A novel electrochemical comparative sensing interface of MgO nanoparticles synthesized by different methods
Authors: Jain Utkarsh , Pundir CS , Gupta Shaivya , Chauhan Nidhi
Published: July 2017

Recent advancements in nanotechnology, for the biosynthesis of metal nanoparticles through enormous techniques, showed multidimensional developments. One among many facets of nanotechnology is to procure and adopt new advancements for green technology over chemical reduction synthesis. This adaptation for acquiring green nanotechnology leads us to a new dimension of nanobiotechnology. In order to imply one such efforts, in this study the emphasis is being laid on the synthesis of MgO nanoparticles using green technology and eliminating chemical reduction methods. Different characterization techniques such as UV–Vis spectroscopy, transmission electron microscopy, and dynamic light scattering were used to carry out the experiments. The average size of MgO nanoparticles were obtained in the range of 85–95 nm, when synthesized by various sources. The extracts of plants were capable of producing MgO nanoparticles efficiently and exhibited good results during cyclic voltammetry and electrochemical impedance spectroscopy study. The electrode modified with MgO nanoparticles (plant extract) showed good stability (90 days) and high conductivity. This study reports cost-effective and environment-friendly method for synthesis of MgO nanoparticles using plant extracts. The process is rapid, simple, and convenient and can be used as an alternative to chemical method.
Effect of tibial coronal inclination on hindfoot kinematics: A biomechanical simulation study
Authors: Seki Hiroyuki , Nagura Takeo , Suda Yasunori , Ogihara Naomichi , Ito Kohta , Matsumoto Morio , Nakamura Masaya
Published: July 2017

Tibial coronal inclination is often recognized in everyday life, but the compensatory kinematic changes to maintain plantigrade of the hindfoot in response to tibial coronal inclination remain unclear. Lower legs and foot specimens obtained from seven human cadavers were loaded vertically with traction of Achilles’ tendon in different tibial inclinations: 0° (neutral), 5°, and 10° medial inclination, and 5° and 10° lateral inclination. The orientations of the tibia, talus, and calcaneus were recorded under vertical load by a three-dimensional digitizing stylus. The angular changes of the talocrural and subtalar joints in the tibial inclinations from neutral were analyzed. The heights of the origins of the talus and calcaneus were also recorded. As the tibia was medially inclined from neutral, the talocrural joint was significantly more dorsiflexed. The subtalar joint was significantly more inverted, plantarflexed, and internally rotated. However, such significant changes in the joint angles were not observed when the tibia was laterally inclined. The height of the talus decreased as the tibia was medially inclined, but it was vice versa when laterally inclined. The compensatory motions of the hindfoot to tibial medial inclination involved coupled movement of both the talocrural and subtalar joints; such motions flatten the medial foot by decreasing the height of the talus. However, such compensatory capacities of the hindfoot to tibial lateral inclinations were limited. Tibial medial inclination under axial loading affects the kinematics of the hindfoot, and this is an important factor to consider in the treatment of flatfoot as well as foot orthotic/footwear intervention.
Assessing Option B+ retention and infant follow-up in Lilongwe, Malawi
Authors: Hauser Blake M , Miller William C , Tweya Hannock , Speight Colin , Mtande Tiwonge , Phiri Sam , Ball LM , Hosseinipour Mina C , Hoffman Irving F , Rosenberg Nora E
Published: July 2017

Malawi launched Option B+, a program for all pregnant or breastfeeding HIV-positive women to begin lifelong combination antiretroviral therapy (cART), in July 2011. This study characterises a portion of the continuum of care within an antenatal setting in Lilongwe. Women testing HIV-positive and having a cART initiation record at Bwaila Antenatal Clinic from July 2013 to January 2014 were included. Using logistic regression models, we analysed relationships between maternal characteristics and return for infant testing. Among 490 HIV-positive women with a cART initiation record, 360 (73%) were retained at three months. Of these, 203 (56%) were adherent. Records of infant testing were located for 204 women (42%). Women who were not retained were less likely to have an early infant diagnosis record (aOR = 0.20; 95% CI: 0.10, 0.41). Among the women retained, there was a non-significant association between maternal adherence and infant testing (OR = 1.35; 95% CI: 0.89, 2.06). Women lost at earlier continuum stages, who are at higher risk for mother-to-child-transmission, were less likely to bring infants for testing. Even with a test-and-treat program, many women did not remain in care or bring their infant for testing. Facilitating strategies to improve these measures remains an important unmet need.
The Effect of Rational and Intuitive Decision-Making Strategies on Interest Appraisals
Authors: Motl Thomas C. , Krieshok Thomas S. , Multon Karen D.
Published: July 2017

Career counseling requires clients to make assessments and predictions of their interests, necessitating the use of both rational and intuitive processes. Dual-processing models of human decision-making have not been experimentally explored within the context of vocational assessment. One-hundred thirty-six participants chose among eight occupational/educational videos after an unconscious-intuitive, conscious-rational, or decision-as-usual information processing manipulation. Participant interest was assessed before, during, and 2 weeks following the video in order to determine differences across conditions. The results yielded three conclusions. First, the unconscious-intuitive manipulation resulted in interest forecasts that were more predictive of actual interest than did the conscious-rational manipulation or the decision-as-usual conditions. Second, interest levels were recalled more accurately by participants who made choices under unconscious-intuitive conditions than by those in the other two conditions. Finally, a history of occupational engagement was found to be related to decisional quality but only for the control group. These results are discussed in the context of vocational theory.
Midterm Results of the Salto Talaris Total Ankle Arthroplasty
Authors: Stewart Matthew G. , Green Cindy L. , Adams Samuel B. , DeOrio James K. , Easley Mark E. , Nunley James A.
Published: July 2017

Background:

The Salto Talaris total ankle replacement is a modern fixed-bearing implant used to treat symptomatic ankle arthritis with the goals of providing pain relief, restoring mechanical alignment, and allowing motion of the ankle joint. The goal of this study was to report the midterm clinical results of one of the largest cohort of patients in the United States who underwent ankle replacement with this prosthesis.

Methods:

This is a review of patients with a minimum of 5 years up to 10 years’ follow-up. At the preoperative visit and each annual assessment, patients rated their current level of pain using the visual analog score (VAS) and reported their functional level using the American Orthopaedic Foot & Ankle (AOFAS) ankle-hindfoot scores, the Short Musculoskeletal Function Assessment (SMFA), and the Short Form-36 (SF-36) Health survey. These scores were analyzed to assess differences between their levels preoperatively, 1 year postoperatively, and at their most recent follow-up. Criteria for failure was defined as revision requiring exchange or removal of the metallic components for any reason. We identified 106 patients having a Salto Talaris total ankle replacement. Seventy-two patients (mean age, 61.9 years) met the minimum requirement for follow-up (range 60-115 months, mean 81.1 months).

Results:

Significant improvements were seen in the VAS, SMFA, AOFAS score, and SF-36 from preoperatively to their final follow-up ( P < .001). Survivorship was 95.8% for those with at least 5-year follow-up, with 2 patients undergoing revision arthroplasty for aseptic loosening and a third patient scheduled for revision for a chronic wound infection. Fourteen patients (19%) required an additional surgery for a total of 17 additional operative procedures on the ipsilateral ankle or hindfoot.

Conclusion:

Patients undergoing total ankle arthroplasty with the Salto Talaris prosthesis continued to show significant improvements in pain and functional outcomes at midterm follow-up. This prosthesis has shown to be an effective treatment option with durable results.

Level of Evidence:

Level IV, therapeutic, case series.
Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy
Authors: Chen Su , Mukherjee Nandini , Janjanam Vimala Devi , Arshad S Hasan , Kurukulaaratchy Ramesh J , Holloway John W , Zhang Hongmei , Karmaus Wilfried
Published: July 2017

Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine (CpG) sites, which show either a significant change or consistency during lifetime. However, the proportion of CpGs that are neither significantly different nor consistent over time (indifferent CpGs) is unknown. We investigated the methylation dynamics, both longitudinal changes and consistency, in women from preadolescence to late pregnancy using DNA-m of peripheral blood cells. Consistency of cell type–adjusted DNA-m between paired individuals was assessed by regressing CpGs of subsequent age on the prior, stability by intraclass correlation coefficients (>0.5), and changes by linear mixed models. In the first 2 transitions (10-18 years and 18 years to early pregnancy), 19.5% and 20.9% CpGs were consistent, but only 0.35% in the third transition (from early to late pregnancy). Significant changes in methylation were found in 0.7%, 5.6%, and 0% CpGs, respectively. Functional enrichment analyses of genes with significant changes in DNA-m in early pregnancy (5.6%) showed that the maternal DNA-m seems to reflect signaling pathways between the uterus and the trophoblast. The transition from early to late pregnancy showed low consistency/stability and no changes, suggesting the presence of a large proportion of indifferent CpGs in late pregnancy.