bluuebunny/crossref_metadata_2025 huggingface dataset:
Langkah-langkah Evaluasi Pembelajaran
Authors: Nur Aidila Fitria  , Muhammad Yoga Julyanur  , Eka Widyanti
Published: August 2024

Learning is a process that aims. Learning objectives that are to be achieved well, of course, should take good ways or steps in knowing the success of students' learning. The extent to which students understand the learning material can only be known by conducting a learning evaluation process. This research is a literature study type research, in which the author collects materials related to the research, both from books, journals, literature, and other publications that are relevant and can be used as sources for further research by the author. As a result, learning evaluation is an assessment carried out by an educator of the extent to which students understand the learning that has been conveyed in teaching and learning activities in order to improve and improve the quality of learning. The types of evaluation such as placement, formative, diagnostic, and summative evaluation play an important role in helping educators and students to achieve the desired learning goals and outcomes. Then, determining the purpose of the evaluation, selecting the evaluation design, validating the data, processing and interpreting the data, providing interpretation and drawing conclusions, and carrying out follow-up evaluation are the steps in the learning evaluation process. Finally, a good evaluation must fulfill characteristics such as validity, objectivity, practicality, and economy in order to provide accurate information and support quality decision-making in the learning process.
Efficacy of CARVYKTI in CARTITUDE-4 versus other conventional treatment regimens for lenalidomide-refractory multiple myeloma using inverse probability of treatment weighting
Authors: Alsdorf Winfried , Diels Joris , Ghilotti Francesca , Mendes João , Hernando Teresa , Cost Patricia , Schecter Jordan M , Lendvai Nikoletta , Patel Nitin , Triguero Ana , Ursi Margherita
Published: August 2024

Aim:
The phase III randomized controlled trial (RCT) CARTITUDE-4 (NCT04181827) demonstrated superiority of CARVYKTI (ciltacabtagene autoleucel; cilta-cel) over daratumumab, pomalidomide and dexamethasone (DPd) and pomalidomide, bortezomib and dexamethasone (PVd) for relapsed/refractory multiple myeloma (RRMM) patients who have received one to three prior line(s) of therapy (LOT[s]) including an immunomodulatory agent and a proteasome inhibitor, and are refractory to lenalidomide. These analyses estimate the relative efficacy between cilta-cel and other common treatment regimens, for which no direct comparative evidence is available.
Materials & methods:
Patient data were available from the CARTITUDE-4, CASTOR, CANDOR and APOLLO RCTs. Imbalances between cohorts on key patient characteristics were adjusted for using inverse probability of treatment weighting (IPTW). Relative efficacies were estimated with response rate ratios (RRs) and 95% confidence intervals (CIs) for overall response rate (ORR), very good partial response or better rate (≥VGPR) and complete response or better rate (≥CR), and with hazard ratios (HRs) and 95% CIs for progression-free survival (PFS). Sensitivity analyses using different analytical methods and additional covariates were explored.
Results:
Key characteristics were well balanced across cohorts after IPTW. Cilta-cel showed statistically significant benefit in PFS (HRs: 0.11–0.51), ≥VGPR (RRs: 1.51–5.13) and ≥CR (RRs: 2.90–35.24) versus all comparators, and statistically significant improvements in ORR over most comparator regimens (RRs: 1.22–1.90). Results were consistent across sensitivity analyses.
Conclusion:
Cilta-cel demonstrated benefit over other common treatment regimens, highlighting its potential to become a new standard of care option for lenalidomide-refractory RRMM patients with one to three prior LOT(s). These comparisons help to demonstrate the improved efficacy of cilta-cel in countries where the standard of care may differ from DPd/PVd.
Implementation of “Test and Treat” Strategy: Analysis of Deaths of People Living with HIV from 2017 to 2022 in Baise City, China
Authors: Liao Jianying , Chen Jian , Safi Sher Zaman , V Samrot Antony , Shah Bin Ismail Ikram
Published: August 2024

Background: Acquired immune deficiency syndrome (AIDS) remains a significant public health concern in China. Treatment coverage has been expanded by revising the antiretroviral therapy (ART) for people living with HIV (PLWH). Several years after implementing the new “Test and Treat” strategy, it is essential to evaluate its impact on people living with HIV since its implementation. Objectives: This study was conducted to comprehensively analyze the deaths of PLWH from 2017 to 2022 in Baise City, China. Methods: A retrospective cohort study was conducted to comprehensively analyze the deaths of PLWH in Baise from 2017 to the first half of 2022. The data was acquired from the AIDS Information System (AIDSIS). The all-cause and AIDS-related mortality rates were calculated for PLWH, along with the proportion of specific death causes. Interrupted time series analysis was utilized to examine changes in all-cause mortality pre- and post-implementation of the new strategy. Kaplan-Meier curves were drawn to compare the mortality risk within 1 year of diagnosis between treated and untreated patients, as well as between late discoverers and non-late discoverers. Related factors of death were also analyzed using the Cox proportional hazards regression model. Results: During the observation period, among a total of 8,922 PLWH cases, 1,265 people died, resulting in an all-cause mortality rate of 4.19 per 100 person-years. Acquired immune deficiency syndrome -related deaths numbered 438, accounting for 34.62% of the total deaths, with a mortality rate of 1.45 per 100 person-years. There were 730 non-AIDS-related deaths, representing 57.71%, with a mortality rate of 2.42 per 100 person-years. The overall mortality rate from all causes within 1 year after diagnosis was 5.58 per 100 person-years. No significant difference was identified in the all-cause mortality rate between the periods before and after the implementation of the new strategy. Untreated PLWH and late discoverers exhibited a high risk of death within 1 year of diagnosis. Most deaths were caused by common chronic diseases, while AIDS-related mortality was mainly due to opportunistic infections. Factors such as gender, age at diagnosis, occupation, educational background, ethnic group, infection route, history of ART, and baseline CD4 level were associated with the risk of all-cause mortality and AIDS-related mortality. Conclusions: After the implementation of the “Test and Treat” strategy, no significant difference in mortality among PLWH was recorded in Baise City, China. We recommend that the health department strengthen the testing of PLWH and improve treatment options. Additionally, we suggest encouraging the maintenance of long-term ART treatment and taking measures to prevent and control tuberculosis and common chronic diseases in individuals who are HIV positive.
The Role of Nitric Oxide in the Proconvulsant Effect of Paraxanthine During the Intravenous Pentylenetetrazole Seizure Threshold Test in Mice
Authors: Jamali Hassan , Esmaili Zahra , Heydari Azhdar
Published: August 2024

Background: Paraxanthine is the major metabolite of caffeine in humans. There is no definitive proof that paraxanthine affects seizures. Nitric oxide (NO) contributes to the central effects of paraxanthine. Objectives: In this study, we examined the effect of acute paraxanthine administration on the pentylenetetrazole (PTZ)-induced seizure threshold, focusing on the NO-cyclic guanosine monophosphate (cGMP) signaling pathway. Methods: Naval Medical Research Institute (NMRI) male mice (25 - 30 g) received paraxanthine (5, 10, 50, and 100 mg/kg) alone. L-arginine [a substrate for NO synthase (NOS)] (50 mg/kg) or L-NAME [a non-selective NOS inhibitor] (5 mg/kg) was administered alone or as pretreatment before the ineffective or effective doses of paraxanthine, respectively. The intravenous PTZ seizure threshold test was used to determine the thresholds for the onset of myoclonic twitch (MCT), generalized clonus (GNC), and forelimb tonus (FLT). Nitric oxide metabolites (NOx) were measured using the Griess method. Results: Paraxanthine administered at doses of 10 and 50 mg/kg significantly reduced the threshold for FLT (P < 0.05 for both). At a dose of 100 mg/kg, paraxanthine significantly reduced the thresholds for the onset of MCT (P < 0.001), GNC (P < 0.01), and FLT (P < 0.001). L-arginine (50 mg/kg), either alone or as pretreatment before paraxanthine (5 mg/kg), did not significantly change the seizure threshold. L-NAME (5 mg/kg) alone had no effect, but L-NAME pretreatment before paraxanthine (100 mg/kg) significantly increased the thresholds for the onset of MCT (P < 0.001), GNC (P < 0.001), and FLT (P < 0.001). Only paraxanthine at a dose of 100 mg/kg significantly increased NOx levels in brain tissues (P < 0.05). Pretreatment with L-arginine further increased the NOx level (P < 0.001), whereas pretreatment with L-NAME decreased it (P < 0.001) compared to the paraxanthine groups. Conclusions: Our results show that paraxanthine has a proconvulsant effect. The results of L-arginine or L-NAME pretreatment before paraxanthine support the possible interaction of the NO-cGMP pathway in the proconvulsant effect of paraxanthine.
Portulaca oleracea Hydroalcoholic Extract Has a Protective Effect Against Cadmium-Induced Nephrotoxicity
Authors: Siahpoosh Amir , Babaei Javad , Jalali Amir , Dehghani Firouzabadi Amir Hossein
Published: August 2024

Background: Recent studies have revealed that Portulaca oleracea possesses both anti-inflammatory and antioxidant qualities. In this work, the effects of P. oleracea methanolic extract against cadmium-induced nephrotoxicity in rats were examined. Methods: Eight separate groups of male albino Wistar rats were randomly assigned to different experimental groups. The initial group was administered normal saline as the control group. The next group was given a single dose of 2 mg/kg of cadmium for two weeks in a row, designated as the positive group. The same daily treatment was given to all three groups, consisting of 3, 4, and 5 rats, for a duration of two weeks. The rats in groups 3, 4, and 5 were given purslane extract in doses of 400, 600, and 800 mg/kg/day, respectively, three hours prior to the administration of cadmium at a dose of 2 mg/kg/day. In the pre-treatment studies, groups 6, 7, and 8 received the extract daily for a period of two weeks at doses of 400, 600, and 800 mg/kg. After the final administration of the extract, cadmium sulfate was administered daily at a dose of 2 mg/kg for two weeks, starting 24 hours later. All administrations were done intraperitoneally. Nephrotoxicity was assessed by measuring serum creatinine (Scr) and blood urea nitrogen (BUN). Furthermore, tissue changes were examined through histopathological observations. Results: The study findings indicated that the levels of BUN and Scr were significantly elevated in the group exposed to cadmium compared to the group given normal saline (P < 0.05). Treatment with P. oleracea effectively reversed these changes towards normal levels (P < 0.05). Furthermore, the results were confirmed and backed up by a histological analysis. Conclusion: Based on these results, P. oleracea extract seems to have potential as a novel preservative to stop further renal damage in cases of renal toxicity caused by cadmium.
Bayesian Spatial Modeling of Landslide Events Using Integrated Nested Laplace Approximation (INLA): A Study Case on Natural Conditions and Community Actions in East Java, Indonesia
Authors: Alfarisi Salman , Christina Athalia , Naqiya Sadiyana Yaqutna , Rachmawati Ro'fah Nur , Machmud Amir , Palupi Endah Kinarya
Published: August 2024

Bayesian Spatial Modeling Using Integrated Nested Laplace Approximation (INLA) is an advanced statistical technique that can be used to model and analyze occurrences in geographic areas.Â Landslides are one of natural disasters that occur due to natural and human factors and pose a serious threat to East Java Province which has complex natural conditions. The disaster brings various losses, including economic, infrastructural, human life, and environmental. This study investigates the factors contributing to landslides across 29 districts and 9 cities in East Java, Indonesia, using spatial regression modeling by Integrated Nested Laplace Approximation (INLA).Â The factors include the number of seaside villages, the number of slope topography villages, and the area of temporarily uncultivated gardens and fields in 2021. The modeling results show that the number of seaside villages, the number of slope topography villages, and the area of fields that are temporarily uncultivated have a significant influence on the occurrence of landslides so that efforts to mitigate and prevent such disasters can be focused on the contributing factors. We conclude that the model might be able to identify potential landslide risk areas through mapping.
Mapping Blue Economy Potential Using Spatial Statistical Downscaling Model: Analysis of the Impact of Climate Change on Freshwater Fish Resources
Authors: Aghnyn Mutiara , Rachmawati Rofah Nur , Abdurrazzaq Achmad , Brahme Nameeta , Dixit Aparna , Hadap Arti
Published: August 2024

Blue Economy is a sustainable economic concept that focuses on utilizing economic resources in marine, coastal and land ecosystems. Sustainable use of freshwater resources in the blue economy for inland waters supports economic growth with environmental balance. The Statistical Downscaling method is used to understand the impact of climate change on freshwater fish resources. To carry out mapping of the potential of the blue economy, it is carried out by statistical downscaling modeling with satellite variables with Integrated Nested Laplace Approximation parameter estimates. The response variable is satellite variables in the form of average rainfall. The modeling results show that Kalipuro District has the highest blue economy potential, while Kalibaru has the lowest. From the research results, that satellite data on average rainfall is a strong basis for printing statistical downscaling, increasing efficiency with open source digital data sources. Satellite data integration, maximizing analysis and comprehensive blue economy potential efficiency.
Potential of Cactus Leather in Pakistan's Leather Industry: A Qualitative Analysis.
Authors: Dr. Ahras Rashid  , Dr. Adeel Shah  , Dr. Sherbaz Khan  , Mr. Afzal Adamjee  , Dr Atif Shahab
Published: August 2024

The rising trend of sustainability worldwide has significantly influenced various industries, transformed not only retail but also reshaped the luxury sector. One notable shift is the increasing focus on vegan leather, with cactus leather emerging as a promising alternative. This study explores the potential of cactus leather in Pakistan, particularly how it can contribute to sustainability in the country's leather industry. By introducing cactus leather, the research aims to raise awareness about sustainable practices and offer a viable alternative to traditional animal leather. The methodology employed in this study is qualitative, based on interviews with leather manufacturers, and the data was analyzed using a thematic analysis framework. The key findings highlight the potential of cactus leather as a sustainable substitute for animal leather, emphasizing its durability, aesthetic appeal, and environmental benefits. Cactus leather not only provides a cruelty-free option but also addresses issues related to pollution and water usage in leather production. The research aims to introduce cactus leather to the Pakistani market, particularly in regions like Thar and Kharan in Sindh and Baluchistan, where cactus farming could thrive and benefit local communities. Cactus leather eliminates the need for animal-based materials, allowing consumers to wear leather products without the associated guilt of animal cruelty. Additionally, the production process of cactus leather is less water-intensive and requires fewer toxic chemicals than traditional leather processing, further reducing its environmental impact. This study underscores the potential for cactus leather to revolutionize the leather industry in Pakistan, aligning with global sustainability trends and offering a practical solution to environmental and ethical concerns.
Razão de Papanicolau na região de saúde de Redenção - PA
Authors: Jordão Lucas Araújo , De Deus Suzana Santana , Matos Fernanda Azevedo , Correia Aline de Castro , De Deus Mariana Santana , Santos Ruann Macedo , Braga Lúcia Beatriz Tanja , Nogueira Renata de Alencar , Gomes Ana Yasmin de Morais , Ferreira Martha Rayssa de Carvalho , Souza Welligton Pereira de
Published: August 2024

No Brasil, o câncer do colo do útero é o terceiro tipo mais incidente entre as mulheres. Este estudo epidemiológico descritivo teve como objetivo analisar a taxa de realização de exame de Papanicolau na Região de Saúde de Redenção, PA, na população feminina de 25 a 64 anos, no período de 2008 a 2021, comparando esses dados com os do estado do Pará, da Região Norte e do Brasil, utilizando a plataforma PROADESS - Projeto de Avaliação do Desempenho do Sistema de Saúde. Depreende-se que a região de Redenção não acompanha os níveis de exames de Papanicolau realizados tanto em âmbito estadual como nacional. O perfil epidemiológico dos exames citopatológicos na Região de Saúde de Redenção revela dificuldades em alcançar mulheres de 25 a 64 anos para a prevenção e rastreamento do câncer de colo do útero. Estes resultados indicam uma lacuna preocupante na cobertura de saúde preventiva na região, evidenciando a necessidade urgente de intervenções direcionadas, como campanhas de conscientização, ampliação do acesso aos serviços de saúde e treinamento de profissionais. Tais medidas são essenciais para aumentar a adesão ao exame de Papanicolau e, consequentemente, reduzir a incidência e mortalidade por câncer do colo do útero na região.
Karakteristik Kekuatan Mekanis Komposit Silencer Gokart
Authors: Arkan Muhamad Fauzan
Published: August 2024

Latar Belakang: Komposit serat karbon dipilih karena keunggulan dalam hal kekuatan tinggi, ringan, dan tahan terhadap suhu tinggi. Silencer pada gokart berfungsi untuk meredam kebisingan yang dihasilkan oleh mesin, dan penggunaan material komposit serat karbon diharapkan dapat meingkatkan performa akustik serta mengurangi berat keseluruhan kendaraan.
Tujuan: Penelitian ini bertujuan untuk menganalisis karakteristik kekuatan mekanis komposit serat karbon yang digunakan sebagai bahan silencer pada gokart.
Metode: Metode penelitian melibatkan pembuatan spesimen uji dari komposit serat karbon dengan matriks resin epoksi. Variasi presentase serat dan orientasi lapisan diuji untuk menentukan konfigurasi yang optimal. Pengujian dilakukan meliputi uji bending, uji impact, dan uji kekerasan vickers untuk mengukur modulus elastisitas dan ketahan terhadap beban dinamis.
Hasil: Hasil pengujian menunjukkan bahwa perbandingan karbon terhadap resin 85/15 menghasilkan kekuatan bending tertinggi (0,712 N/mm²), sedangkan perbandingan 90/10 menghasilkan kekuatan terendah (0,529 N/mm²). Spesimen C dengan perbandingan 80/20 memiliki kekuatan sedang (0,662 N/mm²) dan nilai impact tertinggi (0,751 joule/mm²). Nilai impact terendah didapatkan pada spesimen A dengan perbandingan 90/10 (0,445 joule/mm²). Untuk uji kekerasan Vickers, spesimen B dengan perbandingan 85/15 memiliki kekerasan tertinggi (84,09 HVN), sementara spesimen A dengan perbandingan 90/10 menunjukkan kekerasan terendah (10,4 HVN). Spesimen C dengan perbandingan 80/20 memiliki kekerasan sedang (46,65 HVN).
Kesimpulan:  Berdasarkan hasil penelitian, komposit serat karbon dengan perbandingan karbon terhadap resin 85/15 menunjukkan karakteristik kekuatan mekanis yang optimal untuk digunakan sebagai bahan silencer pada gokart.
PARTICULARITĂȚI ALE TULBURĂRILOR
DE PERSONALITATE LA PREADOLESCENȚII CARE PROVIN DIN FAMILIILE DIVORȚATE
Authors:   Universitatea Pedagogică de Stat „Ion Creangă”, OLĂRESCU VALENTINA , DICU ADRIANA ,   Universitatea Pedagogică de Stat „Ion Creangă”
Published: August 2024

The association between family tensions caused by transitions in parental separation and the effects of the child's adjustment to changes in separation has also been established in numerous studies. The aim of this study was to identify personality disorders in preadolescents living in divorced families compared to those in harmonious, non-divorced families, to facilitate the structuring of psychological interventions oriented/focused on ameliorating these disorders. The sample included 125 children with divorced parents and 103 children from organized families (N = 228 respondents). Self-reported data were collected using the Millon Pre-Adolescent Clinical Inventory (MPACI), authors Theodore Millon, Ph.D., DSc, Carrie Millon, Ph.D., Robert Tringone, Ph.D., Seth Grossman, PsyD. and Hierarchical Personality Inventory for Children (HiPIC), authors I. Mervielde, Ph.D. Filip de Fruyt, Ph.D to capture trends in preadolescent personality traits in the context of divorce. The results obtained on personality characteristics of children from divorced families showed significantly differentiated scores on emerging personality patterns compared to the results reported by children from non-divorced families. Specifically, both on the MPACI, the preadolescents showed impaired psychological development in general, an imbalance in the emerging personality pattern (consistent presence of Conformist,Inhibited, Unstable patterns) and on the HiPIC with respect to Emotional Stability, Extraversion, Imagination and Conscientiousness. Our results help to complete the theoretical and practical bases of psychological science with information on the specific disorders that can be caused in children exposed, directly or indirectly, to conflict situations between their divorced parents.
Effect of KAP-Based Nursing Intervention on Patients Undergoing Coronary Artery Computed Tomography Angiography Review after Percutaneous Coronary Intervention
Authors: Jing Kexin , Gai Xue , Sun Shengjian , Yu Xiaohan , Li Yujia , Hu Jinxiu
Published: August 2024

Objective: This study aimed to analyze the impact of nursing intervention based on knowledge, belief, and action theory (KAP) on patients undergoing coronary computed tomography angiography (CTA) review after percutaneous coronary intervention (PCI). Methods: The research subjects were post-PCI patients who underwent coronary CTA review in our hospital from July 2021, to July 2023. A total of 123 review patients were divided into two groups in accordance with whether they had experienced KAP-based care. The observation and control groups consisted of 65 and 58 cases, respectively (n = 58). The self-rating anxiety scale (SAS), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), CTA image quality, examination cooperation, and nursing satisfaction were compared between the two groups. Results: Compared with those of before nursing, the SAS scores of both groups after nursing were significantly reduced (p < 0.05). Compared with the control group, the observation group had significantly reduced SAS scores (p < 0.05). Compared with those before nursing, the HR, SBP, and DBP of both groups after nursing were significantly reduced (p < 0.05). Compared with the control group, the observation group showed significantly reduced HR, SBP, and DBP (p < 0.05). The grade I rate of the observation group significantly increased, the grade III rate was significantly reduced, and the image quality significantly improved compared with those of the control group (p < 0.05). No statistically significant difference was observed in the incidence of grade II between the two groups (p > 0.05). The total cooperation degree of the observation group was 93.86% (61/65), which was significantly increased compared with the total cooperation degree of 81.03% (47/58) in the control group (p < 0.05). The total satisfaction of patients in the observation group was 96.92% (63/65), which was significantly increased compared with the total satisfaction of 74.14% (43/58) in the control group (p < 0.001). Conclusion: Nursing based on the KAP model during coronary CTA review after PCI can significantly alleviate patients' negative emotions and improve CTA image quality. It can also improve patients' examination cooperation and nursing satisfaction.
Influence of Diabetes Mellitus on Changes in Intra-Operative Decision Making in Coronary Artery Bypass Grafting
Authors: Duggan John P. , Peters Alex S. , Rosenfeld Ethan S. , Antevil Jared L. , Taggart David Paul P. , Trachiotis Gregory D.
Published: August 2024

Background: We evaluated whether patients with diabetes mellitus experienced more surgical strategy changes than patients without diabetes when undergoing coronary artery bypass graft surgery utilizing a protocol for intraoperative high frequency ultrasound and transit-time flow measurement. Methods: Outcomes of coronary artery bypass grafting (CABG) patients with and without diabetes enrolled in the multicenter prospective Registry for Quality Assessment with Ultrasound Imaging and TTFM in Cardiac Bypass Surgery (REQUEST) study were retrospectively compared. The primary endpoint was frequency of intraoperative surgical strategy changes. We also evaluated the differences in patient characteristics and operative characteristics including graft configuration. Results: We compared 614 non-diabetic patients with 402 diabetic patients, among whom 128 were insulin dependent. Patients with diabetes had higher rates of surgical strategy change for the aortic component of the operation (10.2% vs. 6.4%, odds ratio (OR) = 1.67; 95% confidence interval (CI) = 1.06–2.65; p = 0.026). Surgical strategy changes related to in-situ conduits were more common in on-pump procedures in comparison to off-pump in diabetics (4.0% vs. 0%; p = 0.007). Diabetes was associated with less frequent use of bilateral internal mammary arteries (BIMA) (25.6% vs. 33.7%; p = 0.006), more frequent use of radial artery (31.3% vs. 16.9%; p < 0.001) and multi-arterial configuration (48.3% vs. 39.9%, p = 0.009), and more total grafts (3.1 ± 1.1 vs. 2.8 ± 0.9; p < 0.001). Conclusions: When performing isolated CABG on diabetic patients, surgeons were more likely to change surgical strategy for the aortic component of the operation based on high-frequency ultrasound (HFUS), and more likely to make a change related to in-situ conduits in on-pump procedures in diabetics. Among diabetic patients, there was less frequent use of BIMA, more frequent use of radial artery, more frequent multi-arterial configuration, and more total grafts.
A Study on Ejection Fraction in Patients with Mitral and Aortic Regurgitation Based on Cardiovascular Models
Authors: Xing Xuehua , Li Gang , He Zhaoming
Published: August 2024

Background: Whether it is healthy or patients with mitral and aortic regurgitation, clinicians cannot measure the regurgitation of the valve when using two-dimensional echocardiography to measure ejection fraction. Whether the mitral valve and aortic valve are in a healthy state or in a reflux state, there is a reflux volume. The actual stroke output will be less than the stroke output measured by echocardiography, making the calculated ejection fraction higher. Methods: This article proposes for the first time the concept of net ejection fraction (NEF) as the percentage of net stroke output to left ventricular end diastolic volume. The net stroke output is the integral of aortic valve flow during one cardiac cycle at the same time. Using a systemic arterial circulation model, investigate the relationship between ejection fraction and net ejection fraction through numerical simulation methods. Results: The final results showed a strong linear correlation between mitral regurgitation volume (VRmi), aortic regurgitation volume (VRao), and the difference between ejection fraction and net ejection fraction (DEF). The net ejection fraction of the moderate mitral regurgitation group decreased by an average of 26.3% ± 9.95% compared to the ejection fraction measured by echocardiography. The severe mitral regurgitation group showed a decrease of 31.9% ± 9.3%. Moderate descent of aortic valve by 25.8% ± 11.1%. Severe aortic valve descent of 30.9% ± 10.3%. Conclusions: Clinical doctors can evaluate the left ventricular systolic function of patients based on the ejection fraction measured by echocardiography combined with valve regurgitation. The net ejection fraction avoids overestimation of left ventricular systolic function and has high reliability. It can accurately reflect the left ventricular systolic function of patients with mitral and aortic regurgitation, and has certain guiding significance for clinical doctors to grasp the patient's condition.
The effect of progressive muscle relaxation on stress levels and sleep quality in diabetes mellitus sufferers
Authors: Kurniawan Hendri
Published: August 2024

Introduction: Diabetes is a disorder of insulin hormone production that causes blood sugar levels in the body to exceed normal limits, leading to various problems such as stress and poor sleep quality. Progressive Muscle Relaxation (PMR) is a relaxation technique that addresses stress and sleep quality issues. The research aimed to determine the effect of PMR on stress levels and sleep quality in diabetes mellitus sufferers.
Methods: This study employed a pre-experimental design with a one-group pre and post-test design. Sampling was done using purposive sampling with a total of 33 samples. Research variables were measured using the Perceived Stress Scale (PSS) and The Pittsburgh Sleep Quality Index (PSQI). Data analysis was conducted using SPSS 25 with a paired sample t-test.
Results: The majority of samples were elderly (51%) with a female gender predominance (75%) and a duration of diabetes of >5 years (54.5%). Stress was more prevalent among the elderly (23.5%), males (25%), and those with a duration of diabetes <5 years (13.3%). Poor sleep quality was predominantly experienced by late adults (87.5%), males (87.5%), and those suffering for >5 years (83.3%). Samples tended to have moderate to severe stress levels (63.6%) and poor sleep quality (81.8%). After the implementation of PMR, there was a decrease in the mean stress level (3.70) and sleep quality (2.97). The paired sample t-test shows a p-value <0.05, which means there are differences in stress levels and sleep quality in samples before and after PMR.
Conclusions: Progressive muscle relaxation significantly reduces stress levels and improves sleep quality in diabetes mellitus sufferers. Progressive muscle relaxation may be recommended as part of stress management and interventions to improve sleep quality in people with diabetes mellitus. This technique is easy to apply and can be done independently or in structured sessions. Integrating these techniques into diabetes treatment programs can provide additional benefits in managing stress and improving sleep quality, supporting better diabetes management.
Inovasi Jajanan Tradisional Indonesia–Perancis: Klepon Choux au Craquelin
Authors: Mahmudi  , Daniel Pandu Mau  , Amanda Setia Subagyo
Published: August 2024

Kuliner Indonesia memiliki keanekaragaman, baik dari makanan modern maupun tradisional. Kepopuleran jajanan tradisional ini semakin hari semakin berkurang, dikarenakan jajanan modern yang mulai bermunculan di kawasan kuliner Indonesia. Tujuan penelitian ini untuk mengetahui perpaduan jajanan tradisional Indonesia dan Perancis. Jenis penelitian kualitatif deskriptif. Adapun teknik pengambilan data dengan wawancara metode pembuatan klepon dan resep Perancis. Hasil penelitian ini menunjukkan produk klepon dapat dimodifasikasi menjadi jajanan modern yaitu Klepon Choux au Craquelin. Selain itu, produk ini dibuat sebagai salah satu cara untuk melestarikan jajanan tradisional Indonesia yang mulai terlupakan dan juga memberikan kesempatan kepada masyarakat untuk menikmati rasa klepon dengan cara lain.
Intervalos de confiança nas análises com dados de inquérito populacional: gráfico Equiplot
Authors: SOARES FABIANA , Luciano Carneiro Alves de Oliveira Bruno , Emanuella Emanuella , Maria da Silva Freitas Francisca , Feres de Sousa Bruno , Miranda dos Santos Alcione
Published: August 2024

Objetivo: Este artigo propôs uma rotina para o software R-Studio que torne adequada a compreensão das iniquidades em saúde ao produzir o Equiplot com Intervalos de Confiança de 95% (IC95%) com dados de inquéritos populacionais com amostragem complexa. Métodos: Analisaram-se comportamentos de saúde de adultos (18 a 64 anos) no Brasil incluídos na Pesquisa Nacional Saúde 2013 (n=52.490) e 2019 (n=72.605). Estudo transversal comparou em gráficos Equiplot as prevalências com e sem seus respectivos IC95% do tabagismo atual; uso abusivo de álcool; atividade física no lazer; consumo de frutas e vegetais ou legumes segundo o tipo de cidade no país (Capital, Região Metropolitana excluindo capital e Interior). Diferenças foram consideradas estatisticamente significantes ao nível de 5% na ausência de sobreposição dos IC95%. Resultados: As capitais apresentaram prevalências mais elevadas dos comportamentos saudáveis e consumo excessivo de álcool, e menor de tabagismo atual. A análise do Equiplot só com prevalências indicou diferenças estatisticamente significantes na prática de atividade física no lazer e no uso excessivo de álcool em 2013, e no tabagismo atual e o consumo adequado de verduras nos dois anos. Porém, ao se adicionar IC95%, observou-se sobreposição de alguns deles, modificando a compreensão dos achados antes interpretados sem IC95%. Conclusões: A rotina proposta para o R-Studio é uma alternativa para a confecção do gráfico Equiplot com dados amostrais de inquéritos populacionais, permitindo adequada e simultânea comparação e interpretação das prevalências e IC95% que revelem a presença e a dinâmica das iniquidades
Postoperative Complications of Third Molar Surgical Extraction in a Malaysian Sample
Authors: Kashmola Muhanad Ali , Mustafa Nazih Shaban , BT Kamaludin Latifi Fadhlin Amalia , BT Mohamad Fadzli Mawaddah Munirah
Published: August 2024

The most common impacted teeth in adults are the mandibular third molars which frequently require surgical extraction. There are many factors contributing to the occurrence of postoperative complications, one of which is surgeon’s experience. Hence, this study aimed to determine the prevalence of postoperative complications of third molar extractions by different level of surgical experience. Methods: A retrospective study was conducted in Kulliyyah of Dentistry, International Islamic University Malaysia. A total of 112 cases were collected from the records of surgical extraction of lower third molars performed by dental students, dental officers and specialists, collected data was transferred into special case sheets and analyzed using IBM SPSS 23. Results: From 112 cases, 64(57.1%) had presented with postoperative complications. The highest prevalence of postoperative complications was in dental students’ group 38 out of 62 patients (61.3%), followed by specialists’ group 20 out of 39 patients (51.3%) and dental officers’ group 6 out of 11 patients (51.6%). Meanwhile, the common complications observed were pain (33.9%), swelling (20.5%), trismus (12.5%), paresthesia (6.3%) and bleeding (3.0%). Conclusions: There is no statistically significant correlation between the postoperative complications and the level of surgeons’ experience.
PENDAMPINGAN DALAM MENYUSUN LAPORAN KEUANGAN PELAKU USAHA DI PALANGKA RAYA
Authors: Nahan Noorjaya , Abdi Muhamad Ruzaini
Published: August 2024

Pentingnya kegiatan pengabdian kepada masyarakat dalam kegiatan pendampingan penyusunan laporan keuangan pada pelaku usaha di Palangka Raya. Pendampingan dalam penyusunan laporan keuangan memiliki peran vital dalam mendukung keberlanjutan dan pertumbuhan bisnis. Melalui berbagai metode pendampingan seperti konsultasi tatap muka, online, workshop, coaching berkelanjutan, dan penggunaan software akuntansi, pelaku usaha dapat meningkatkan pemahaman finansial, menghindari kesalahan dalam pencatatan, serta mematuhi regulasi yang berlaku. Kegiatan ini dilakukan pada kelompok UMKM Kerupuk ikan sebanyak 25 kelompok di tangkiling kota Palangka Raya. Tanpa pendampingan, pelaku usaha menghadapi risiko besar seperti kesalahan dalam penyusunan laporan, pengambilan keputusan yang tidak tepat, serta sulitnya mengakses pendanaan. Untuk mencapai hasil yang optimal, kombinasi metode one-on-one coaching dengan evaluasi berkelanjutan, dilengkapi dengan workshop awal dan integrasi teknologi, merupakan pendekatan yang paling efektif. Pendampingan yang tepat memastikan pelaku usaha tidak hanya mampu menyusun laporan keuangan yang akurat, tetapi juga membangun kapasitas internal untuk mengelola keuangan bisnis secara mandiri dan efisien di masa depan.
Promosi Villa Kayu Putih
Authors: Satrianto Alpisa  , Defrizal Saputra
Published: August 2024

Villa kayu putih one of the villa that locate at Jorong Galagah Alahan Panjang, Lembah Gumanti Sub District, Solok Regency. Villa Kayu Putih do not have a catalog yet as a promotion and information media, thus making the customer having a hard time to obtain the information about facilities and service of Villa Kayu Putih. So the author decided to designing promotional media that is informative, communicative, useful and interesting to market the products to be offered. The design method used is the glass box method with SWOT analysis techniques. This design uses a simple concept where this style will make the information to be conveyed look clear and simple so it is easy to understand. The main media designed is e-catalog which will provide information about Villa Kayu Putih's products, facilities and services, also accompanied by other supporting media such as printed catalogs, Instagram content, posters, x-banners, stickers, t-shirts, business cards , and key chains.
Adherence to low tidal volume in the transition to spontaneous ventilation in patients with acute respiratory failure in intensive care units in Latin America (SPIRAL): a study protocol
Authors: Diniz-Silva Fabia , Pinheiro Bruno Valle , Reyes Luis Felipe , Cavalcanti Alexandre Biasi , Figueredo Belinda , Rios Fernando , Machado Flávia Ribeiro , Preda Gabriel , Bugedo Guillermo , Maia Israel Silva , Silveira Leda Tomiko Yamada da , Herrera Luis , Jibaja Manuel , Ibarra-Estrada Miguel , Cestari Mino , Nin Nicolás , Roldan Rollin , Santos Tiago Mendonça dos , Veiga Viviane Cordeiro , Bruhn Alejandro , Ferreira Juliana Carvalho
Published: August 2024

ABSTRACT Objective: Patients with acute respiratory failure often require mechanical ventilation to reduce the work of breathing and improve gas exchange; however, this may exacerbate lung injury. Protective ventilation strategies, characterized by low tidal volumes (≤ 8mL/kg of predicted body weight) and limited plateau pressure below 30cmH2O, have shown improved outcomes in patients with acute respiratory distress syndrome. However, in the transition to spontaneous ventilation, it can be challenging to maintain tidal volume within protective levels, and it is unclear whether low tidal volumes during spontaneous ventilation impact patient outcomes. We developed a study protocol to estimate the prevalence of low tidal volume ventilation in the first 24 hours of spontaneous ventilation in patients with hypoxemic acute respiratory failure and its association with ventilator-free days and survival. Methods: We designed a multicenter, multinational, cohort study with a 28-day follow-up that will include patients with acute respiratory failure, defined as a partial oxygen pressure/fraction of inspired oxygen ratio < 300mmHg, in transition to spontaneous ventilation in intensive care units in Latin America. Results: We plan to include 422 patients in ten countries. The primary outcomes are the prevalence of low tidal volume in the first 24 hours of spontaneous ventilation and ventilator-free days on day 28. The secondary outcomes are intensive care unit and hospital mortality, incidence of asynchrony and return to controlled ventilation and sedation. Conclusion: In this study, we will assess the prevalence of low tidal volume during spontaneous ventilation and its association with clinical outcomes, which can inform clinical practice and future clinical trials.
Penyuluhan Pengolahan Limbah Pertambangan Emas Rakyat di Desa Dalam
Authors: Suhadi  , Sueb  , Sari Murni Sapta , Syamsussabri Muhammad , Kiswojo
Published: August 2024

Desa Dalam, Kecamatan Taliwang, Kabupaten Sumbawa Barat, Provinsi Nusa Tenggara Barat merupakan salah satu desa dengan jumlah penambang rakyat yang cukup banyak yang termasuk dalam pertambangan skala kecil yang menggunakan metode amalgamasi dan sianidasi dalam pengolahan emas. Aktivitas ini sangat banyak dilakukan dikarenakan lebih mudah untuk  dilakukan. Tujuan dalam pelaksanaan pengabdian ini yaitu untuk memberikan penyuluhan pengolahan limbah pertambangan emas. Metode pelaksanaan dilakukan dengan penyuluhan secara langsung pada penambang dan diskusi interaktif secara langsung di lokasi penambang. Kegiatan ini dilakukan di Desa Dalam dengan jumlah penambang yang sebanyak 23 orang. Titik lokasi pengabdian langsung dilakukan di lokasi pertambangan emas rakyat yang ada di dua titik utama. Pada pengabdian yang sudah dilakukan terdapat beberapa kegiatan yang dilakukan guna meningkatkan pemahaman dan kesadaran masyarakat terhadap isu pertambangan rakyat yakni penyuluhan kepada Penambang, dan Masyarakat Umum.
Determination of Pollution from Bilge Water in Mersin Port
Authors: Özkan Yılmaz Ferbal , Nas Orhan , Özlüer Hunt Arzu
Published: August 2024

The problem of marine pollution caused by ships has become very important in recent years as a result of the increase in maritime transportation. This study aimed to evaluate ship bilge water in terms of marine pollution. Bilge water samples of two different ships in Mersin Taşucu Port were taken to determine pH, color, total nitrogen, total phosphorus, suspended solids (SS), hydrocarbon oil index (HOI), chemical oxygen demand (COD), biological oxygen demand (BOD), surfactant analyzes were performed. The results obtained were compared with the values specified in the Water Pollution Control Regulation. Analysis values of bilge water samples taken from Ship 1 and Ship 2 are respectively SS 472 mg/L-812 mg/L; HOI 110.6-138.8 mg/L; COD 8870.4-17369.6 mg/L; BOD 1606.4 to 3881.1 mg/L were determined. According to the Table given by the Water Pollution Control Regulation for deep discharge, the limits are SS 350 mg/L, oil-grease 15 mg/L, COD 400 mg/L and BOD 250 mg/L. It was determined that the values obtained in this study were higher than the desired limits and bilge water should not be discharged directly into the sea.
Functional Outcome Measures after Operative Management of Acetabular Fractures
Authors: Delizo Shiela Marie , Banggiacan Rodel , Garin Isagani
Published: August 2024

Objectives. This study evaluated the functional outcome of patients with acetabular injuries using the Majeed pelvic score. The specific objectives were to assess any differences in functional outcomes among patients treated with early versus delayed surgery and those with or without concomitant injuries.
Methodology. Patients from our institution, Baguio General Hospital and Medical Center, with acetabular injuries from January 2019 to December 2022, were included. Patients with acetabular fractures with or without other injuries were included. All available data sources were reviewed, such as charts from hospital records, patient census, and electronic medical records. Patients underwent physical therapy before discharge and were followed up. The patients’ outcomes after surgical intervention were assessed using Majeed's pelvic score.
Results. Thirteen patients were included in the study with follow-ups ranging from one to three years. A functional assessment using Majeed's pelvic score with a mean of 83 points (range 72–100). The majority had good functional outcomes.
Conclusions. Early surgical intervention may have no advantage over delayed surgeries regarding functional outcomes. However, concomitant injuries and complications may contribute to a poor to fair functional outcome.
Stakeholders’ longitudinal perspectives on a large public housing redevelopment in Los Angeles, California
Authors: Perrigo Judith L. , Scott Jose J. , Shier Victoria , Datar Ashlesha
Published: August 2024

The Homeownership and Opportunity for People Everywhere VI programme (HOPE VI) model created a new approach to redeveloping public housing in the US, paving the way for the Choice Neighborhoods Initiative (CNI). Unlike traditional public housing redevelopment, CNI aims to revitalise entire ecosystems to create sustainable, thriving communities by focusing on housing, people, neighbourhoods and participatory community planning. This study used qualitative methods to explore the longitudinal perspectives of 12 stakeholders involved in a large CNI-funded public housing redevelopment project in Los Angeles, California. Our grounded theory analysis identified four key themes: (1) persistent community ghosts; (2) growing regeneration rooted in optimism and hope for the future; (3) displacement concerns; and (4) the emergence of a mixed-income dichotomy. These findings underscore the importance of continued community involvement in redevelopment efforts, especially in communities that bear complex historical and social challenges.
Respecting, retaining, recreating: The successful renovation of the Beijing 751 D-Park
Authors: Guo Fang Bin , Wang Yonggang
Published: August 2024

Post-industrial sites in Chinese cities are being redeveloped as catalysts for urban regeneration and economic development. Calling the shift from ‘Made in China’ to ‘Created in China’, the Chinese government is encouraging the development of the creative industry to transform post-industrial sites. Successful examples of city renewal projects provide examples of this strategy, tuning into the creative cultures and industrial heritage of these cities and offering platforms for creative enterprises to flourish. This paper describes a recently funded renovation project, Beijing 751 D-Park, which has been undertaken to analyse these opportunities, and offers the initial findings of a case study. It unlocks the development process of the renovation project in terms of its philosophy, design method and planning strategy.
Incentivising the market to build affordable housing: The New York City toolkit
Authors: Luo Yuxiang
Published: August 2024

Affordable housing is among the biggest policy challenges facing cities worldwide. Treating New York City as a case study, this paper reviews a multifaceted toolkit to combat the housing crisis. Specifically, the analysis focuses on how the government incentivises real estate developers to build affordable housing, with both financial incentives such as tax abatements, tax credits and loans funded by tax-exempt bonds and non-financial means such as zoning regulations. The study demonstrates both the successes achieved by New York City and the unintended consequences that emerged from these interventions, and the research argues that beyond financial and economic considerations, long-range spatial planning factors play a pivotal role in the formulation of effective affordable housing policies. The research underscores the need for policy makers globally to take a holistic approach and integrate various elements of city growth to address the intricate challenges posed by housing crises in urban environments.