bluuebunny/crossref_metadata_2025 huggingface dataset:
Frontline brentuximab vedotin in Hodgkin lymphoma and CD30-expressing peripheral T-cell lymphoma for older patients and those with comorbidities.
Authors: Yasenchak Christopher A. , Bordoni Rodolfo Eduardo , Yazbeck Victor Y. , Patel-Donnelly Dipti , Larson Tim , Sims Robert Brownell , Mei Matthew Genyeh
Published: May 2020

TPS8069

Background: Older patients and those with significant comorbidities have not attained outcomes seen in younger patients with classical Hodgkin lymphoma (cHL) and CD30-expressing peripheral T-cell lymphoma (PTCL). Five-year progression-free survival (PFS) was 30%–45% in older HL patients treated with combination chemotherapy versus 75%–80% in younger patients (Evens 2008; Proctor 2009). Similarly, when adjusted for age, a Charleston Comorbidity Index ≥2 was independently associated with worse overall survival (HR=1.63) and PFS (HR=1.54) (Ellin 2018). Brentuximab vedotin (BV, ADCETRIS), a CD30-directed antibody-drug conjugate, has robust activity in cHL patients refractory to several lines of chemotherapy. BV monotherapy in 27 cHL patients aged ≥60 years had a 92% objective response rate (ORR) and 73% achieved complete remission (Forero-Torres, 2015). BV was also active and well-tolerated in CD30-expressing PTCL patients with relapsed or refractory disease (Horwitz 2014). Frontline BV monotherapy may have the potential to be an active and well-tolerated treatment for cHL and PTCL patients who are older or have significant comorbidities, which are populations with high unmet need. Methods: This phase II, open-label study, SGN35-015 (NCT01716806), has added 2 cohorts to evaluate the efficacy and tolerability of BV monotherapy in treatment naive patients with cHL, (Part E), or CD30-expressing PTCL (Part F, n~50 each) who are unsuitable for conventional combination therapy due to comorbidity-related factors as determined by a Cumulative Illness Rating Scale (CIRS) score ≥10 or dependence on others for any instrumental activities of daily living. Eligible patients must also have an Eastern Cooperative Oncology Group (ECOG) performance status ≤3 and measurable disease ≥1.5 cm per radiographic techniques. BV (1.8 mg/kg) will be administered as a single intravenous infusion on day 1 of each 2-day cycle. Patients achieving a complete remission, partial remission, or stable disease will receive up to 16 cycles of treatment. Response will be assessed by blinded independent central review of spiral CT and PET scans at Cycles 2, 6, 11, and at end of treatment to be graded per Lugano 2014. The primary objective of these cohorts is to assess ORR of frontline therapy with single-agent BV in patients who have significant comorbidities. Clinical trial information: NCT01716806 .
DREAMM-9: Phase III study of belantamab mafodotin plus VRd versus VRd alone in transplant-ineligible newly diagnosed multiple myeloma (TI NDMM).
Authors: Usmani Saad Zafar , Terpos Evangelos , Janowski Wojt , Quach Hang , West Sarah , Williams Danae , Dettman Elisha J. , Ferron-Brady Geraldine , Luptakova Katarina , Gupta Ira
Published: May 2020

TPS8556

Background: Bortezomib, lenalidomide, and dexamethasone (VRd) is the standard of care for transplant-eligible and TI NDMM, but relapse is usually inevitable. The median progression-free survival (PFS) is ~3 years for patients with TI NDMM, and with each relapse, the duration of response (DoR) diminishes, highlighting the need for novel, effective, targeted agents. Single-agent belantamab mafodotin is a first-in-class B-cell maturation antigen–binding, humanized, afucosylated, monoclonal immunoconjugate, showing deep and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma ( Lancet Oncol2020). Preclinical work suggests belantamab mafodotin plus bortezomib or lenalidomide enhances anti-myeloma activity. Therefore, studying clinical activity of belantamab mafodotin in combination with these agents is warranted. Methods: DREAMM-9 (NCT04091126) is a two-part, open-label study to determine efficacy and safety of single-agent belantamab mafodotin with VRd vs. VRd alone in patients with TI NDMM. Patients aged ≥18 years with ECOG status 0–2 and adequate organ system functions will be eligible. Part 1 (dose selection) will evaluate safety/tolerability of belantamab mafodotin with VRd administered by single (Day 1) or split dosing (Days 1 and 8) in ≤5 cohorts (n = 12/cohort): 1.9 mg/kg, 2.5 mg/kg split and single, and 3.4 mg/kg split and single. Six more patients may be added to cohort(s) most likely to be selected as recommended Phase III dose (RP3D). Dose-limiting toxicities and adverse events (AEs) will be assessed, and belantamab mafodotin RP3D determined through modified toxicity probability interval criteria. Part 2 (randomized Phase III) will determine efficacy and safety of belantamab mafodotin at RP3D with VRd vs. VRd alone (n = 750) in two arms randomized 1:1. Dual primary endpoints will be rate of minimal residual disease (MRD) negativity and PFS. Secondary endpoints will be response rates (overall response, complete response, very good partial response or better, sustained MRD negativity), DoR, time to progression, and overall survival. Safety assessment will include AEs, serious AEs and ocular findings. In both parts, belantamab mafodotin will be given with VRd for eight induction cycles and then with Rd for maintenance until disease progression or unacceptable toxicity. Funding: GlaxoSmithKline (209664). Drug linker technology licensed from Seattle Genetics; monoclonal antibody produced using POTELLIGENT Technology licensed from BioWa. Clinical trial information: NCT04091126 .
Phase I study of AMG 757, a half-life extended bispecific T-cell engager (HLE BiTE immune therapy) targeting DLL3, in patients with small cell lung cancer (SCLC).
Authors: Owonikoko Taofeek Kunle , Borghaei Hossein , Champiat Stéphane , Paz-Ares Luis G. , Govindan Ramaswamy , Boyer Michael J. , Johnson Melissa Lynne , Udagawa Hibiki , Hummel Horst-Dieter , Salgia Ravi , Blackhall Fiona Helen , Boosman Rene J. , Lai Wei-Chu Victoria , Dowlati Afshin , Vokes Everett E. , Hann Christine L. , Chiang Anne C. , Endraca Marichu , Soman Neelesh , Smit Marie-Anne Damiette
Published: May 2020

TPS9080

Background: SCLC is an aggressive neuroendocrine tumor with poor prognosis and few treatment options. Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand that is highly expressed on the surface of most SCLC tumors but minimally expressed in normal tissues. As such, DLL3 may be a promising therapeutic target. AMG 757 is an HLE BiTE immune therapy designed to redirect cytotoxic T cells to cancer cells by binding to DLL3 on cancer cells and CD3 on T cells, resulting in T cell activation and expansion and T cell-dependent killing of tumor cells. In addition to its direct antitumor effect, BiTE immune therapy can inflame the tumor microenvironment. Combining AMG 757 with a PD-1 pathway inhibitor may lead to increased antitumor activity by enabling sustained T cell-dependent killing of tumor cells. Methods: NCT03319940 is an open-label, ascending, multiple-dose, phase 1 study evaluating AMG 757 as monotherapy; the protocol was recently amended to also evaluate AMG 757 in combination with pembrolizumab. The study will include a dose exploration (monotherapy and combination) followed by a dose expansion (monotherapy). Key eligibility criteria: adult patients with relapsed/refractory SCLC whose disease progressed or recurred after at least 1 platinum-based chemotherapy regimen, ECOG performance status 0–2, at least 2 measurable lesions per modified RECIST 1.1, no untreated or symptomatic brain metastases, and adequate organ function. Primary objectives are to evaluate safety/tolerability and determine the maximum tolerated dose or recommended phase 2 dose of AMG 757 as monotherapy and in combination with pembrolizumab. Secondary objectives are to characterize pharmacokinetics and evaluate preliminary antitumor activity; exploratory objectives are to assess immunogenicity and changes in biomarkers in blood and tumor tissue. In the dose exploration phase, dose escalation/de-escalation decisions will be guided by a Bayesian logistic regression model; backfill enrollment at dose levels deemed safe and tolerable will be allowed. The study is open and recruiting patients. Clinical trial information: NCT03319940.
A phase I/II study of REGN5093, a MET x MET bispecific antibody, in patients with MET-altered advanced non-small cell lung cancer (NSCLC).
Authors: Rowlands Tracey , Boyapati Anita , Li Siyu , Daly Christopher , Seebach Frank A. , Lowy Israel , Rietschel Petra
Published: May 2020

TPS9628

Background: Mesenchymal-epithelial transition (MET) factor is a transmembrane tyrosine kinase receptor activated by hepatocyte growth factor (HGF). Aberrant activation of MET via gene amplification or gene mutations, as well as MET protein overexpression, has been reported in NSCLC and other cancer types and can promote tumorigenesis. REGN5093 is a human bispecific antibody that binds to two distinct epitopes of MET, blocking HGF binding and inducing internalization and degradation of MET. REGN5093 prevents MET-mediated signaling and inhibits growth of MET-driven tumor cells without inducing MET-driven biological responses (DaSilva et al, CCR, 2019; PMID: 31848185). Methods: This Phase I/II, first-in-human, multicenter study is investigating the safety, tolerability, pharmacokinetics (PK), and efficacy of REGN5093 in patients with MET-altered advanced NSCLC who have received all available approved therapies (NCT04077099). Key eligibility criteria include age ≥18 years, Eastern Cooperative Oncology Group performance status of ≤1, and documented presence of either MET exon 14 gene mutation and/or MET gene amplification and/or elevated MET protein expression. Patients are required to provide a biopsy during screening for assessment of MET biomarkers. Key exclusion criteria include prior MET-targeted biologic therapy (expansion cohorts only). Prior therapy with tyrosine kinase inhibitors are not exclusionary in any part of the study. For each patient, the study comprises a screening period of up to 28 days, followed by 3-week cycles of REGN5093 monotherapy. Study treatment will continue until confirmed disease progression or other protocol-defined reason for discontinuation. The study has two parts: dose escalation and dose expansion. Dose escalation will proceed via 4+3 design until a maximum-tolerated dose is reached or a recommended Phase II dose selected. The primary objective of the dose escalation part is to assess safety (incidence and severity of adverse events and Grade ≥3 laboratory abnormalities), tolerability (incidence of dose-limiting toxicities), and PK of REGN5093. During the expansion phase, patients will be allocated to cohorts according to the type(s) of documented biomarkers of MET-altered disease. Anti-tumor activity based on objective response rate per Response Evaluation Criteria in Solid Tumors version 1.1, determined by CT or MRI, will be the primary endpoint in the expansion cohorts. The study is currently open for enrollment. Clinical trial information: NCT04077099 .
Phase IIa study of marrow infiltrating lymphocytes (MILs), an adoptive T cell therapy, alone or in combination with nivolumab in non-small cell lung cancer (NSCLC).
Authors: Edelman Martin , Lisberg Aaron Elliott , Koczywas Marianna , Creelan Ben C. , Seiz Amanda , Lutz Eric , Rudraraju Lakshmi , DeOliveria Elizabeth , Shah Monil , Noonan Kim , Johnson Melissa Lynne
Published: May 2020

TPS9630

Background: Primary or secondary resistance to anti-PD-1 may be due to loss of T cell function. Persistent antigen stimulation can lead to impaired CD8+ T cell function, which often results in acquired resistance to PD-1 inhibition. It is unclear whether reinvigoration of tumor infiltrating cells or recruitment of novel T cells impart the activity of anti-PD-1 therapy. The bone marrow is a reservoir for antigen experienced memory T cells. We have previously shown that MILs can be generated for patients with hematologic malignancies and solid tumors including patients with NSCLC. MILs are the product of the activation and expansion of bone marrow T cells with a polyantigenic memory phenotype that recognize tumor antigens, are cytotoxic to autologous tumor and are able to persist over a long period of time. In a pre-clinical study of NSCLC, MILs were able to be expanded in all patients tested. Furthermore, all of the NSCLC products tested showed specificity to shared NSCLC antigens. The combination of adoptive cell therapy (ACT) with checkpoint inhibitors (CPIs) has distinctive positive effects on CD8 and CD4 T cell subsets, with the possibility for complete tumor control. We hypothesize that patients with NSCLC who have relapsed on anti-PD-1 treatment could benefit from an infusion of non-exhausted, central memory-enhanced, antigen specific T cells i.e. MILs which can delay the induction of tumor-associated anergy and augment the overall effectiveness of immunotherapy. Methods: Patients with advanced NSCLC who have progressed following prior anti-PD-1 therapy, with sufficient bone marrow reserve and an ECOG 0-1 are eligible. In eligible patients, bone marrow (200 mL) will be harvested and processed. Patients will undergo lymphodepletion (fludarabine 300 mg/m2/day and cyclophosphamide 30 mg/m2/day on days -5,-4,-3) followed by infusion of MILs on day 0. In Part 1, up to 6 patients will be administered MILs alone on day 0. In Part 2, approximately 20 subjects will be administered MILs on day 0 followed by NIVO 480 mg Q4W starting on day 1. The objectives of the study are to assess safety of MILs alone and in combination with NIVO, as well as efficacy. The first patient was treated in December 2019. Clinical trial information: NCT04069936 .
Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma
Authors: Brown Taylor C , Nicolson Norman G , Man Jianliang , Gibson Courtney E , Stenman Adam , Juhlin C Christofer , Korah Reju , Carling Tobias
Published: May 2020

Tumorigenesis requires mitigation of osmotic stress and the transcription factor nuclear factor of activated T cells 5 (NFAT5) coordinates this response by inducing transcellular transport of ions and osmolytes. NFAT5 modulates in vitro behavior in several cancer types, but a potential role of NFAT5 in adrenocortical carcinoma (ACC) has not been studied. A discovery cohort of 28 ACCs was selected for analysis. Coverage depth analysis of whole-exome sequencing reads assessed NFAT5 copy number alterations in 19 ACCs. Quantitative real-time PCR measured NFAT5 mRNA expression levels in 11 ACCs and 23 adrenocortical adenomas. Immunohistochemistry investigated protein expression in representative adrenal samples. The Cancer Genome Atlas database was analyzed to corroborate NFAT5 findings from the discovery cohort and to test whether NFAT5 expression correlated with ion/osmolyte channel and regulatory protein expression patterns in ACC. NFAT5 was amplified in 10 ACCs (52.6%) and clustered in the top 6% of all amplified genes. mRNA expression levels were 5-fold higher compared with adrenocortical adenomas (P < 0.0001) and NFAT5 overexpression had a sensitivity and specificity of 81.8% and 82.7%, respectively, for malignancy. Increased protein expression and nuclear localization occurred in representative ACCs. The Cancer Genome Atlas analysis demonstrated concomitant NFAT5 amplification and overexpression (P < 0.0001) that correlated with increased expression of sodium/myo-inositol transporter SLC5A3 (r2 = 0.237, P < 0.0001) and 14 other regulatory proteins (P < 0.05) previously shown to interact with NFAT5. Amplification and overexpression of NFAT5 and associated osmotic stress response related genes may play an important role adrenocortical tumorigenesis.
Logical goal-setting frameworks for leprosy projects
Authors: Ogbeiwi Osahon
Published: May 2020

Background/aims

Goal setting is a fundamental practice in the effective management of healthcare services worldwide. This study investigated the extent to which leprosy goal formulation in Nigeria is logical and SMART.

Methods

Document review of baseline problems, goal statements and goal attainments for 2016 in six leprosy projects using a customised logical framework matrix.

Results

A total of 15 main problems, 6 aims, 19 objectives and 42 indicators were found. The goals were problem-based and logically linked, with a pattern of a single aim per project, multiple objectives per aim, and multiple indicators per objective. Goal statements specified only impact in 5 out of 6 aims, and only outcome and terminal timeframe in 17 out of 19 (89.5%) objectives. Only one objective stated all four SMART components of outcome, indicator, target and timeframe. While three (7.1%) indicators and two (10.5%) objectives were measurable, no target was attainable.

Conclusions

Goal-setting frameworks for leprosy projects should be problem based and logical according to best practice. That most leprosy objectives were not completely SMART is similar to the reported structure of objectives published by other health organisations globally.
Patient expectations of healthcare in relation to the management of venous leg ulcers
Authors: Haynes Samantha
Published: May 2020

The demand for healthcare resources continues to grow as a result of the ageing population and the increased prevalence of long-term conditions. Meanwhile, the public's expectations of healthcare are increasing, which is putting an exceptional strain on the NHS' resources. Leg ulcers, particularly venous leg ulcers, are common in older age. The costs associated with the management of individuals with ulcers is high, not only to the NHS but also to the patient, in terms of loss of mobility and the associated effects on their health-related quality of life. This article explores some of the issues related to healthcare demands and patients' expectations of healthcare in relation to the management of venous leg ulcers in England.
Revolutionising the wound care pathway for patients with lower limb wounds
Authors: Adderley Una
Published: May 2020

Lower limb ulceration is common and costly, with evidence of variation in practice and under-use of evidence-based care. This has resulted in poor healing rates and exacerbated costs. Commissioning to achieve better organised care that supports early delivery of evidence-based interventions is needed to improve the management of this very common condition in community and primary care.
Psoriasis: more than skin deep
Authors: Greener Mark
Published: May 2020

Often perceived as ‘just’ a skin condition, psoriasis often affects people's mental health, and undermines their educational and occupational prospects. Mark Greener argues that effective treatment could reduce the burden of this disease on society, the NHS and patients.
Celebrating nurses with more time to care
Authors: Wadsworth Dan
Published: May 2020

Dan Wadsworth, Transformation Manager at TeleTracking International explains how small changes can have very significant results, not least in enabling far more time to care
Need for age- and memory-friendly housing environments is urgent!
Authors: Rappe Erja
Published: May 2020

Countries are ageing globally, which has effects on both the individual and societal levels. Adjustments in the living environment of older people are often needed in order to enable a comfortable and independent everyday life for them. The housing environment is important for healthy and active ageing, which can support the physical, psychological and social well-being of older people. This article discusses global ageing and the challenges connected with it, the characteristics of age- and memory-friendly environments and housing, and how to develop these, providing examples of different housing solutions.
Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents
Authors: Yu Linhui , Thurston Elizabeth M. S. , Hashem Mada , Dunn Jeff F. , Whelan Patrick J. , Murari Kartikeya
Published: May 2020

Hemodynamic parameters, such as tissue oxygen saturation and blood volume fraction, are important markers of brain physiology. They are also widely used surrogate markers of electrophysiological activity. Here, we present a single fiber spectroscopic (SFS) system for monitoring cerebral oxygen saturation in localized, non-line-of-sight brain regions in freely-moving rodents. We adapted the implantation ferrule and patch cable design from commercialized optogenetics and fiber photometry systems, enabling stereotaxic fiber implantation, longitudinal tissue access and measurement from freely-moving animals. The optical system delivers and collects light from the brain through a 200 µm-core-diameter, 0.39NA multimode fiber. We robustly measured oxygen saturation from phantoms with different optical properties mimicking brain tissue. In mice, we demonstrated, for the first time, measurements of oxygen saturation from a highly-localized, targeted brain region over 31 days and continuous measurements from a freely-moving animal for over an hour. These results suggest that single fiber spectroscopy has enormous potential for functional brain monitoring and investigating neurovascular coupling in freely-moving animals. In addition, this technique can potentially be combined with fiber photometry systems to correct for hemodynamic artifacts in the fluorescence detection.
Terahertz composite plasmonic slabs based on double-layer metallic gratings
Authors: Liu Dejun , Chen Lin , Wu Xiaohu , Liu Feng
Published: May 2020

One composite plasmonic slab with a broad bandgap (40%) is experimentally and numerically demonstrated in the terahertz (THz) region. The composite slab consists of double-layer metallic gratings and a dielectric film, which supports two resonant modes. Electric field vectors and charge distributions proved that the low-frequency resonant mode originates from the symmetric plasmonic mode, while the high-frequency resonant mode is induced by the hybrid mode of plasmonic and dielectric modes. Compared with the double-layer metallic grating, the inserted dielectric film significantly enhances the transmission of the transverse magnetic (TM) waves and induces Fano resonances. The near-field coupling between metal gratings and dielectric film can be manipulated by changing the thickness and the refractive index of dielectric films. We further demonstrated that the plasmonic bandgap can be manipulated by tuning the grating width. These results suggest that this composite plasmonic slab is promising in terahertz integrated components development such as a filter, polarizer, or sensor.
Multiphysics model of liquid-cooled Nd:phosphate split-slabs in large aperture optical amplifiers
Authors: Chonion R. , Sajer J. M. , Bordenave E. , Le Palud F. , Dalbies P. M. , Neauport J.
Published: May 2020

High repetition rates in high energy solid-state laser systems can yield to a rise of temperature in amplifiers despite the use of cooling systems. This effect can significantly impact the performance of amplifiers by inducing thermal stress, birefringence or thermal lensing. Here, we develop a multiphysics model to support the design, optimization and commissioning of a liquid-cooled large aperture split-slab laser glass amplifier. This multiphysics model includes optical pumping in the amplifying medium, heat loading, hydraulic effects induced by the liquid coolant, mechanical deformation and their potential coupled effects on the optical wavefront. The accuracy of each model is assessed by carrying out specific experimental measurements and characterizations. We show that this set of models allows the prediction of performance of a liquid-cooled amplifier from the flash-lamp emission to the amplified wavefront at a repetition rate of one shot per minute.
Quantum dot-based broadband optical antenna for efficient extraction of single photons in the telecom O-band
Authors: Yang Jingzhong , Nawrath Cornelius , Keil Robert , Joos Raphael , Zhang Xi , Höfer Bianca , Chen Yan , Zopf Michael , Jetter Michael , Luca Portalupi Simone , Ding Fei , Michler Peter , Schmidt Oliver G.
Published: May 2020

Long-distance fiber-based quantum communication relies on efficient non-classical light sources operating at telecommunication wavelengths. Semiconductor quantum dots are promising candidates for on-demand generation of single photons and entangled photon pairs for such applications. However, their brightness is strongly limited due to total internal reflection at the semiconductor/vacuum interface. Here we overcome this limitation using a dielectric antenna structure. The non-classical light source consists of a gallium phosphide solid immersion lens in combination with a quantum dot nanomembrane emitting single photons in the telecom O-band. With this device, the photon extraction is strongly increased in a broad spectral range. A brightness of

17

%

(numerical aperture of 0.6) is obtained experimentally, with a single photon purity of

g

(
2
)

(
0
)
=
0.049
±
0.02

at saturation power. This brings the practical implementation of quantum communication networks one step closer.
IT-Governance, Risiko- und Compliance-Management (IT‑GRC) – Ein Kompetenz-orientierter Ansatz für KMU
Authors: Johannsen A. , Kant D.
Published: May 2020

Kleine und mittlere Unternehmen aller Branchen versuchen sich nach wie vor angemessen mit den Herausforderungen der Globalisierung und der digitalen Transformation auseinanderzusetzen. Sie bilden in diesem Zusammenhang wachsende Kompetenz in der Produktionsautomatisierung (Industrie 4.0) und in digitalen Geschäfts- und Verwaltungsprozessen aus. In Bezug auf IT-GRC bleiben KMU demgegenüber faktisch oft noch unreif. Bestehende Ansätze des IT-Governance‑, Risiko- und Compliance-Managements sind noch zu wenig für KMU ausgestaltet. Der Artikel stellt vor diesem Hintergrund einen zunächst aus der Literatur abgeleiteten, und dann zusammen mit Feedback von 14 IT-GRC Experten aufgestellten, Kompetenz-orientierten Ansatz zur Wahrnehmung, Messung und Steuerung des IT-Governance, Risiko- und Compliance-Managements in KMU vor. Der Ansatz enthält sechs relevante Kompetenzkategorien. Der Beitrag stellt dann zwei abgeleitete, webbasierte Tools zur Messung und Erfassung der Handlungsbedarfe und zur Unterstützung von Management-Maßnahmen vor. Der Ansatz sowie die prototypisch realisierten Tools unterstützen das IT-GRC Management von KMU gemäß ihrem Reifegrad und bedarfsorientiert. Bei der Unterstützung wird der Fokus darauf gelegt, KMU bei der Umsetzung der ständig wachsenden IT-GRC-Anforderungen schlanke und konkrete Methoden, Werkzeuge und Hilfsmittel an die Hand zu geben und die verschiedenen Stakeholder einzubinden.
„Wenn ich es nicht schaffe, liegt es an meiner Person und nicht an meiner Leistung“ – Die Individualisierung struktureller Probleme im Coaching weiblicher Führungskräfte. Genderlinguistische und gendertheoretische Erkenntnisse für die Praxis.
Authors: Graf Eva-Maria , Fleischhacker Melanie
Published: May 2020

Diese Fallstudie fokussiert die Individualisierung struktureller, d. h. organisationaler und sozialer, Probleme im Rahmen einer Coaching-Erstsitzung zwischen einer weiblichen Führungskraft und einer weiblichen Coach. Die Gesprächsdaten werden mit Hilfe der Kritischen Diskursiven Psychologie und ihren Konzepten interpretative repertoires, ideological dilemmas und subject positions analysiert. Die Analyse nimmt dabei explizite und implizite Genderrepräsentationen in den Blick und zeigt auf wie die Beteiligten stereotype Annahmen über Gender im Kontext des Anliegens reproduzieren und (unhinterfragt) übernehmen; dabei wird es versäumt, vom Individuum der Klientin auf die zugrundeliegenden strukturellen Bedingungen des Systems zu verweisen und so Entlastung herbeizuführen. Das Ziel der angewandt-genderlinguistischen Studie ist es, ein Bewusstsein bei Coaches für die Omnipräsenz und Omnirelevanz von oftmals naturalisierten und normalisierten Genderdiskursen im Coaching von weiblichen Führungskräften zu schaffen.
A hazai környezetvédelmi infrastruktúra fejlesztési projektek szervezeti háttere
Authors: Szabó Ferenc
Published: May 2020

Effective planning, preparation, implementation and operation of projects need modem organisational solutions. Successful project management requires effective daily operation, flexible structure, adaptive and innovative organisational culture, coordination mechanisms that assure fast decision-making and responses. The appropriate organisational form is based on personal motivation and responsibility, parallel with the possibility of cooperation and teamwork. Several international, national, regional and local organisations are involved in Hungarian environmental infrastructure development projects supported by the EU. Their organisational structures and cultures are not always optimal for project management. Organizational differences in some cases make effective cooperation impossible. In my paper I present the organisational background of one of these projects, the Szeged Regional Waste Management Program based on interviews conducted with some actors of the project, ease studies and document analysis.
Croatian-Hungarian trans-border relationships from state socialism until today, with special attention to the euroregions
Authors: Bali Lóránt
Published: May 2020

On the whole we can claim that in the last almost sixty years there was a significant change in Croatian-Hungarian trans-border relationships. State-governed cooperation was replaced by project-controlled co-operations under the guidance of local-governments and the civil sphere. Unfortunately, stock and human workforce deficit very often obstructs success. Besides it is a permanent problem in our country that state politics has a great influence on local-government politics. So in a certain euroregion the success of operation highly depends on where the local-governments and civil organization belong to politically and on the leaders' ability to validate their interests. As a result of stock deficit mentioned previously project-based co-operations occurred.1 But these ad hoc project associations are not able and won't even be able to use union sources efficiently and generate any kind of long-term regional development.
A különleges minőségű élelmiszerek vidékfejlesztésben betöltött szerepe
Authors: Panyor Ágota
Published: May 2020

In our work the concept of "special foods" - in a wider sense - is defined as foods not yet widespread in public consumption. They represent special quality, which - in our opinion - may derive from traditions, from geographical properties related to food production or from the organic nature of production. The main characteristics of individual groups of special foods (foods originating from organic production, geographical indications products, traditional and local foods) are reviewed and proposals are made for improving the quality of life and for increasing the population-retaining capacity in rural regions. Special foods represent a higher added value, their production offers a possibility for inhabitants in rural areas to make agricultural production more diverse, to popularize the products of disadvantaged regions and to increase the farmers' income.
A magyarországi pecsenyecsirke-ágazat múltja és jelene, versenyképességének elemzése
Authors: Vincze-Lendvai Edina
Published: May 2020

In Hungary in the last 5 years the meat-production and consumption is uncertain. The habits of the consumers have changed, the meat-prices have grown and new animal-diseases have appeared. The changes reached the poultry-sector too. In my work I show the development of the poultry branch, examined the broiler sector - its most important factors, and made a SWOT-analysis about the competitiveness of this department. .
Információs technológiák és menedzsment folyamatok, BPM
Authors: Marosi Tibor , Vukoszávlyev Szlobodan
Published: May 2020

Napjaink vállalkozásainak, - a folyamatosan változó piaci követelmények és az érdekeltjeik igényeinek egyre inkább kiszélesedő skálája következtében, - olyan mértékű piaci versennyel kell szembe nézniük, melynek csak megfelelően kidolgozott üzleti folyamatokkal felelhetnek meg. Korunk vállalatainak folyamatos versenykihívásai közé tartozik a nyereségesség megtartása, versenyképesség megőrzése, a folyamat optimalizáció és az új piacok szerzése. Legjobb megoldást jelentheti, ha a vállalat tisztában van saját folyamataival és megpróbálja azt a leghatékonyabb eszközökkel működtetni, javítani. A dolgozatban bemutatásra kerül az információs technológiák és az üzleti folyamatok kapcsolata, az üzleti folyamat menedzsment (BPM) jelentősége és alkalmazásának előnye.
Hőkezelési folyamat számítógépes modellezése
Authors: Fabulya Zoltán , Hampel György
Published: May 2020

The heat treatment of cans, particularly canned meat, is a process with a big energy need, since the cans need sterilization, a heat treatment with a long time span around 120°C with the use of fuel gas in big quantity. The reduction of the use of the natural resources is the challenge in our days which appears in the new system approach of the environment management, the principle of sustainable development. That is to say, let us produce the same amount of products with less energy consumption, or more amounts with less specific energy consumption. The heat treatment is used to avert microbiological danger. The operation regulation has to be defined in a way which produces a microbiologically reliable product, but does not harm its organoleptic peculiarities, substance, taste and flavour because of the oversized treatment. In the interest of safety we have to define the extent and the time span of the heat effect leading to the destruction of the microbiological pathogens with the use of engineering calculations, modelling and computer simulation. We also have to secure the observance of the regulations obtained this way for the sake of the higher quality and the less resource utilization. This observance ability is answered with the help of our developed model for the computer simulation of heat treatment processes.
Az önkormányzati együttműködés zavarai a Szeged Regionális Hulladékgazdálkodási ISPA projekt üzemeltetésének kezdeti szakaszában
Authors: Szabó Ferenc
Published: May 2020

On the basis of a case study I present the experiences of the operation and the typical operational conflicts of the completed Hungarian EU environmental infrastructure development projects, first of all from the aspect of the cooperation of the beneficiary local governments. In the analyzed case - „Szeged Regional Waste Management Program" ISPA project - the legal beneficiary is the municipality of Szeged, but the other 32 municipalities of the region are also interested in the successful implementation of the project and are responsible for the continuous long run operation.
Az elterelt fiatalok családi hátterének jellemzői Szabolcs-Szatmár-Bereg megyében
Authors: Barabásné Kárpáti Dóra
Published: May 2020

In the past 10-15 years, the consumption of illegal drugs has increased significantly both in Hungary and in our county. In parallel with the society's getting more and more open, the fulfilment of personal freedom, and the spreading of globalisation and individual culture, the use of drugs has become more and more accessible and acceptable to the young. This study briefly overviews the family background and problems of provincial young people consuming drugs. I have studied 3 problems within this topic: family structure, relations with parents, and family members' drug consumption behaviour. I suppose that family problems are connected with the interviewees' alcohol and other drug consumption. In my research I apply the Euroadad questionnaire. The sample covers 144 interviewees, 76.9% of whom have been "diverted" from jurisdiction. The other respondents have volunteered for the therapy.I have processed the data with the SPSS statistical program package. Having studied the respondents' family structure, I have found no significant difference regarding the co-habitation data for the past 30 days or the past year. The family members' alcohol and drug consumption bears a greater relation to the use of legal drugs than of prohibited ones. The family problems related to parents are connected to the young people's prohibited and legal drug consumption, and fathers play a particularly stressed role. The groups of party drug and amphetamine consumers struggle with more family problems than the groups of marijuana users.
A házasságkötések számának alakulása Mezőhegyesen
Authors: Zsótér Brigitta
Published: May 2020

During the examined period the number of matrimonies drastically decreased. The reasons can be the following ones: firstly, the biggest firm of the settlement, which gave the highest number of workplaces, was closed down at the end of the 90s, then the majority of the young intelligentsia moved, together with their families, to the neighboring big cities, the children of these families are now at the marriageable age. The other reason: the young who went to the neighboring big cities (for example: to Szeged) in their teens to study there, came back to Mezőhegyes in a very small number because they did not find work there. The third possible reason: the financial support given by the local authority and by the biggest employer of the settlement - Mezőhegyesi Ménesbirtok Zrt. - to the young couple ceased to exist. The majority of the local marriages is between inhabitants of Mezőhegyes. There is a certain proportion where the wife or the husband is not from Mezőhegyes. In the case of some marriages both parts of the couple are not local inhabitants. The number of settlers and so the number of marriages can be increased with new workplaces, with supports from both the local authority and the employers.
A projektmenedzsment szervezeti háttere
Authors: Keczer Gabriella
Published: May 2020

One of the key conditions of successful project management is finding the most effective organizational solution. A project can be managed either in our organization (in functional or matrix structure, or by creating an individual project unit), or we can contract with another company. In my paper I summarize and evaluate these organizational solutions on the basis of its literature, and I present a case study: the organizational background of an environmental infrastructure development project in Szeged.
Adsorción de Cadmio, Cobre y Plomo en Bentonita, Caolín y Zeolita Naturales y Modificadas: Una Revisión de los Parámetros de Operación, Isotermas y Cinética
Authors: Carbonel Dalia
Published: May 2020

Contexto: La adsorción es un proceso efectivo para el tratamiento de aguas residuales contaminadas con metales pesados. El uso de adsorbentes de bajo costo incrementa la ventaja y competitividad de este proceso. Arcillas y zeolitas, naturales y modificadas, han sido usadas ampliamente para la remoción de metales pesados de aguas residuales.

Método: Se revisaron, analizaron y compararon los estudios, realizados durante la última década, referentes a la adsorción de cadmio, cobre y plomo por bentonita, caolín y zeolita, naturales y modificadas.

Resultados: Se analizan diferentes parámetros de operación, condiciones de equilibrio y cinética. Los parámetros de operación estudiados son la concentración inicial de metales, pH de la solución, dosis de adsorbente y temperatura del sistema. Se presenta una recopilación de la eficiencia de los sistemas respecto a la capacidad máxima de adsorción. Se discuten los modelos de isotermas usados para analizar el equilibrio de adsorción así como los modelos cinéticos y de difusión en los estudios revisados.

Conclusiones: El uso de bentonita, caolín y zeolita es efectivo para la remoción de cadmio, cobre y plomo de soluciones acuosas. La influencia de diversos parámetros de operación se ve reflejado en la variabilidad de las capacidades de adsorción de cadmio, cobre y plomo. En relación al equilibrio de adsorción en la mayoría de estudios revisados la isoterma de Langmuir es la que mejor se ajusta a los datos. En cuanto a la cinética el modelo de pseudo-segundo orden es el que mejor se ajusta a los datos.
Nie-Tan Method and its Improved Version: A Counterexample
Authors: Salazar Omar , Rojas Juan Diego , Serrano Humberto
Published: May 2020

Context: The bottleneck on interval type-2 fuzzy logic systems is the output processing when using Centroid Type-Reduction + Defuzzification (CTR+D method). Nie and Tan proposed an approximation to CTR+D (NT method). Recently, Mendel and Liu improved the NT method (INT method). Numerical examples (due to Mendel and Liu) exhibit the NT and INT methods as good approximations to CTR+D.Method: Normalization to the unit interval of membership function domains (examples and counterexample) and variables involved in the calculations for the three methods. Examples (due to Mendel and Liu) taken from the literature. Counterexample with piecewise linear membership functions. Comparison by means of error and percentage relative error.Results: NT vs. CTR+D: Our counterexample showed an error of 0.1014 and a percentage relative error of 30.53%. This is respectively 23 and 32 times higher than the worst case obtained in the examples. INT vs. CTR+D: Our counterexample showed an error of 0.0725 and a percentage relative error of 21.83%. This is respectively 363 and 546 times higher than the worst case obtained in the examples.Conclusions: NT and INT methods are not necessarily good approximations to the CTR+D method.
Transformación de la no-Complejidad a la Complejidad
Authors: Maldonado Castañeda Carlos Eduardo
Published: May 2020

Contexto: Este artículo aborda un problema nuevo y difícil: la manera como un fenómeno o sistema simple o lineal puede ser transformado gracias a la geometría de fractales en un sistema o fenómeno complejo. En este sentido, el contexto es el de las ciencias de la complejidad. El problema es altamente significativo, pues de manera general siempre se ha dicho que la complejidad trata, entre otros, con comportamientos no-lineales.Método: El método es eminentemente teórico. En la bibliografía especializada el problema nunca se ha trabajado, y si sí, como un sistema simple o complicado puede ser cambiado en uno complejo o no-lineal.Resultados: Los resultados indican que es posible abordar el problema y resolverlo satisfactoriamente, atendiendo a los más destacados antecedentes en la materia. Se presentan varios argumentos que remiten entre otros a G. Julia y Mandelbrot.Conclusiones: La conclusión es que la geometría de fractales suministra bases suficientes para estudiar la transformación estudiada. Así, la importancia teórica y práctica del problema considerado puede extenderse a numerosos campos; aquí se explora y se muestra, por primera vez, como dicha transformación es posible.
Métrica de Hausdorff en el ambiente difuso
Authors: Ochoa Castillo Carlos Orlando , Forero Vega Laura Victoria
Published: May 2020

Contexto: De manera intuitiva, se ha establecido el concepto de conjunto como una colección distinta de elementos, esto es, un conjunto se determina vía la relación de pertenencia de un elemento de un universo al conjunto. La situación, por supuesto, es si pertenece o no pertenece; en un subconjunto difuso a cada elemento del universo se le asocia con un grado de pertenencia, que es un número entre  0 y 1. Los subconjuntos difusos se establecen como una correspondencia entre cada elemento del universo y un grado de pertenencia.Método: El estudio fue basado en trabajos anteriores como artículos o libros, en donde autores exponen ideas sobre la importancia de los subconjuntos difusos y la necesidad de crear con ellos nuevas teorías y espacios.Resultados: Al combinar dos teorías, se genera un nuevo ambiente de estudio que permite afirmar que la distancia de Hausdorff corresponde, extiende y ajusta la nocion de distancia entre subconjuntos no vacíos compactos en el ambiente de los espacios métricos, mas exactamente en (R n , du).Conclusiones: La construcción realizada permite obtener un espacio métrico con varias cualidades, en donde se puede afirmar que son consequencia del objeto de estudio inicial
Modelación Integrada de Sistemas Socio-ecológicos Complejos: Caso de Estudio la Ecorregión de la Mojana
Authors: Villegas Gonzalez Paula Andrea , Florez Florez Maria Juliana , Triviño León Nathaly , Escobar Jorge Alberto , Obregón Neira Nelson , González Méndez Alex Mauricio , González Salazar Ramon Eduardo
Published: May 2020

Contexto: Se ha observado que la modelación de sistemas socio-ecológicos complejos a partir de simulaciones basadas en agentes, tienen la ventaja de integrar diferentes procesos, escalas, variables y la posibilidad de generar escenarios con actores en el marco de procesos de modelación participativa.Método: Se diseña una herramienta computacional para la planificación y apoyo a los procesos de toma de decisión relacionados con la gestión de los recursos hídricos, específicamente para el caso de las inundaciones en la ecorregión de la Mojana (Colombia). Son desarrollados talleres de participación social relacionados con creencias, valores, redes sociales y resiliencia.Resultados: El modelo tiene dos componentes: el primero representa la hidrodinámica de las inundaciones por medio de la plataforma numérica ISIS 2D; el segundo, en relación con los aspectos sociales de la región, se maneja a través de modelado de sistemas de agentes. Ambos sistemas están integrados  en la plataforma NetLogo.Conclusiones: La modelación integrada de sistemas socio-ecológicos complejos permite visualizar el comportamiento de la población y los recursos naturales en un territorio, contribuyendo al diseño de políticas y los procesos educativos con la participación de diferentes disciplinas y actores. Trabajos futuros, pueden enfocarse en la modelación regional y el análisis del impacto producido por el uso de estas herramientas.
Separating families, recuperating the “nation-as-family”: Migrant youth and the cultural politics of shame
Authors: Chang Ethan , Koyama Jill , Kasper Julie
Published: May 2020

This study investigates the intersections of policy, affect, and the lives of migrant youth. We approach the Trump Administration’s contingent reversal of a “zero tolerance” family separation policy as an illustrative case for understanding how affect mediates policy-making processes. Combining Critical Policy Analysis (CPA) and affect studies, we analyze 184 print media texts between the declaration of zero tolerance (May 2018) and President Trump’s repeal of his executive order (June 2018). We argue that mainstream media invited publics to sympathize with migrant youth and shame zero tolerance policy and its defenders. While shame catalyzed nationwide #KeepFamiliesTogether protests, it also animated political actions that recuperated “America” as a tolerant nation (e.g., “Love, not hate, makes America great”). In doing so, shame suppressed structural critiques of U.S. state violence toward migrant as well as Black, Indigenous, and minoritized families and youth. We conclude by discussing how a “pedagogy of discomfort” offers one way to build toward more historically responsive and intersectional coalitions for migrant and education justice.
Attitude stabilization control for quadrotor using self-tuning fuzzy-PD
Authors: Sumardi Sumardi , Afrisal Hadha , Dyan Nugroho Wisnu
Published: May 2020

This research aims to develop a quadrotor control system for maintaining its position and balance from disturbance while hovering. A fast and reliable control technique is required to respond to high maneuverability and high non-linearity of six degrees of freedom system. Hence, this research focuses on designing a Self-Tuning Fuzzy-PD control system for quadrotor’s attitude. The designed control system utilizes input data from the Inertial Navigation System (INS). Then the quadrotor’s attitude is controlled by passing the PWM signal to the flight controller APM 2.6. The result shows that the average absolute error for the roll, pitch, and yaw angles are relatively small, as mentioned consecutively 2.0790, 2.2660, and 1.5280, while the maximum absolute errors are 6.3140, 6.7220, and 3.820.