bluuebunny/crossref_metadata_2025 huggingface dataset:
WORKPLACE VIOLENCE AGAINST HEALTHCARE WORKERS IN JEDDAH: DETERMINANTS, PERCEIVED IMPACTS AND CAUSES
Authors:   Preventive Medicine Postgraduate Program, Ministry of Health, Jeddah, Saudi Arabia., Alhaeli Alaa , Ali Khalawi Alaa ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., Eldeb Mohammed Mohammed ,   King Abdul Azeez Medical City National Guard Specialized Polyclinic, Jeddah, Saudi Arabia., Baker Banamah Omar ,   King Abdul Azeez Medical City National Guard Specialized Polyclinic, Jeddah, Saudi Arabia., Ali Khalawi Yaseen ,   Dental Center, Uhud Hospital, Madinah Health Complex, Ministry of Health, Saudi Arabia., Abdullah Badawood Mohammed ,   King Abdul Azeez Medical City National Guard Specialized Polyclinic, Jeddah, Saudi Arabia., Saleh Mohamed Hassanien Noha ,   High Institute of Public Health, Department of Biostatistics, Alexandria University, Egypt.
Published: August 2023

Background: Healthcare workers are particularly vulnerable to workplace violence, impacting their mental health and performance at work. This study aims to assess the extent of workplace violence in Jeddahs healthcare facilities, and its determinants. Methodology: This cross-sectional study was conducted on 402 healthcare workers in Jeddah, Saudi Arabia, using a questionnaire that evaluate workplace violence, the impact of violent incidents, reporting of incidents, mitigation strategies, and risk factors associated with workplace violence. Results: Verbal violence was prevalent, with 65.4% of participants experiencing it, while physical violence was reported by 8.7% of the respondents, over a third (34.6%) never experienced verbal violence, while 13.7% encountered daily verbal violence. Females were more significantly affected by verbal violence compared to males. Physical violence was more prevalent among non-Saudi providers (p=0.015), and primary healthcare workers were more prone to physical violence than hospital workers (p=0.002). Nurses were more exposed to physical violence than physicians (p=0.015). Verbal and physical violence were significantly higher in emergency departments (p=0.003 and p=0.006, respectively). Workplace violence had various impacts on participants, including reduced motivation and efficiency, a desire to change their work, and negative effects on personal well-being and mental health. Common causes reported include overcrowding, disrespect towards healthcare workers, lack of punishment for aggressors, and long waiting times in healthcare facilities. Conclusions: Workplace violence is prevalent in the healthcare facilities in Jeddah, mostly in primary healthcare centers and emergency departments, and female and non-Saudi workers are the most vulnerable, with various undesired impacts.
DEMYSTIFYING THE ROLE OF NITRATE TRANSPORTERS IN PLANT DEFENSE
Authors:   School of Sciences, P PSavani University, Surat-394125, Gujarat, India., Wany Aakanksha , Kumar Ashutosh ,   School of Sciences, P PSavani University, Surat-394125, Gujarat, India., Jha Rajesh ,   School of Sciences, P PSavani University, Surat-394125, Gujarat, India.
Published: August 2023

Plants are frequently exposed to a variety of soil-borne or airborne diseases during its life, which pose a threat tothe safety and security of the worlds food supply. Due to millions of years of evolution, plants have developed multi-layered defense mechanisms to detect and offend the invasion of these diverse harmful microbes, such as viruses, bacteria, nematodes, and fungi.Plant defense mechanisms are greatly influenced by nitrogen nutrition. The form of nitrogen nutrition, either nitrate (NO3-) or ammonium (NH4+), plays a very important role in plant defense. Both these forms of N, have tight coordination with a group of transporter proteins called nitrate transporters. The critical role of NO3- transporters in mediating the absorption and its long-distance transport have been the subject of several researches however, little is known about the transport systems involved in NO3- re-allocation under the influence of biotic and abiotic stressors. NO3- transporters are essential to know how plants react to challenging environmental conditions. In fact, when less NO3- is sent to the shoot, plants adapt to environmental stress better. The role of NO3- transporters in helping plants thrives in several challenging environmental cues. As a matter of fact, under different stresses, the amount of NO3- that is translocated from roots to shoots fluctuates, which may have an impact on plants NUE either favorably or unfavorably.
IMPACT OF COVID-19 ON SICKLE CELL DISEASE PATIENTS A NARRATIVE REVIEW
Authors:   Senior Preventive Medicine Resident, Joint Program of Preventive Medicine, Al-Ahsa, Community Medicine Department, Al-Ahsa Health Cluster, Saudi Arabia., Abdullmohsen Alnasser Hussien , Mohammed Alsaleh Essa ,   Consultant Physician of Epidemiology and Public Health, Infection Control Administration at AlAhsa Health Directorat,Saudi Arabia.
Published: August 2023

Objective:Thereviewaimedto examine the evidencefortheimpactofCOVID-19onSickleCellDisease(SCD) patients. Background: Coronavirusdisease (COVID-19) continues to ravage various parts of the world, with increasing cases of morbidity and mortality. The coronavirus primarily targets therespiratory system, although it affects other organs. Evidence shows that patients with pre-existingconditions, suchas SCD,areato higherriskofdevelopingsevereCOVID-19illness anddeath. Methods:Anarrativereview wasconductedthroughacomputerizedsearchonthePubMeddatabase.Tenarticlesmettheinclusioncriteriaandwereincludedinthesynthesis. Discussion:Thefindings ofthereview showthatSCD patientsareatincreasedriskofsevereillnessanddeathwheninfectedwithCOVID-19duetotheirimmunocompromisedstate. Although there is heterogenicity in results, most studies concur that SCD complications such asVaso-occlusive crisis (VOC), Acute Chest Syndrome (ACS), stroke, and acute anemia pose thegreatestriskofmorbidityandmortality.However,mostpatientsshowfavorableoutcomeswhenprovidingwith properintervention. Conclusion:Basedonthefindingsofthisreview,patientswithSCDhavesignificantlyadverseCOVID-19outcomes.
ANALYSING HAND HYGIENE KNOWLEDGE AND ATTITUDE AMONG MEDICAL STUDENTS AND NURSING STAFF: IDENTIFYING THE GAPS
Authors:   Associate Professor,Department of Microbiology, All India Institute of Medical Sciences, Nagpur., Gade Neeta , Nag Soumyabrata ,   Assistant Professor, Department of Microbiology, All India Institute of Medical Sciences, Nagpur., Mishra Meena ,   Professor and Head,Department of Microbiology, All India Institute of Medical Sciences, Nagpur., Biswas Rahul ,   Assistant Professor, Department of Community Medicine, Medical College, Kolkata., Shete Vishal ,   Assistant Professor, Department of Microbiology, All India Institute of Medical Sciences, Nagpur., Sahu Vinod ,   Nursing Officer, All India Institute of Medical Sciences, Nagpur.
Published: August 2023

Background: Hand hygiene is regarded as the cornerstone of infection control practices to reducethe cross-transmission of microorganisms, healthcare-associated infections, and the spread of antimicrobial resistance across all healthcare settings. Assessment of knowledge and attitude towards hand hygiene among healthcare workers is essential to plan interventions to improve adherence to hand hygiene. Objective: The present study aimed to study the knowledge and attitude towards hand hygiene among medical students and nursing staff of a newly established tertiary care academic institute in centralIndia. Materials and methods: This Cross-sectional study included 247 participants comprising undergraduate medical students and nursing staff. They were assessed for knowledgeand attitude on hand hygiene using a questionnaire. The data were analyzed using the software SPSS (version 21). Result: In the present study, both the group of participants, nursing staff and medical students, had a fair knowledge of many aspects of hand hygiene which was a positive sign. Nursing staff had significantly better knowledge than undergraduate medical students on hand hygiene(p<0.001). The majority of students and nursing staff had positive attitudes about hand hygiene. Conclusion: Though the participants had general knowledge about hand hygiene, they differed in certain areas, like the type of hand hygiene method required in different situations. Identifying the gaps in knowledge regarding hand hygiene helps to plan interventions to improve compliance with hand hygiene.
PHYSICAL AND PHYSIOLOGICAL COMPARISON BETWEEN BALL AND RACKET GAMES PLAYERS
Authors:   Research Scholar, Banaras Hindu University, Department of Physical Education, Varanasi, India., Halder Sajal , Ghildyal Sushma ,   Professor, Banaras Hindu University, Department of Physical Education, Varanasi, India.
Published: August 2023

The purpose of the studies was to compare the physical and physiological variables of ball and racket games players. For accomplishing the study, twenty (n=20) players were selected from each discipline. The total forty (n=40) players were selected through random sampling technique. Twenty (n=20) players were selected from ball game (Handball) and twenty (n=20) were selected from racket game (Badminton) from Burdwan University, West Bengal, India. Subjects had represented in the district level tournament. The age of the subjects ranged between 18to 21 years. The pertaining data was collected on physical variables: Speed, Agility, Arm power and Leg power, with the Johnson and Nelson motor ability test. Physiological variablesi.e.blood pressure was measured with the digital sphygmomanometer and VO2max was measuredwith Cooper test. Descriptive statistics (Mean & S.D.) and inferential statistics(S.E. & t- test) were used as statistical techniques to find out the difference in physical variables(Speed, Agility, Arm power and Leg power)and physiological variables (Blood pressure, VO2max) between Ballgame(Handball)and Racket game(Badminton)players.To compare resultst- test was used as statistical technique. The level of significance was set at (P>0.05). The results showed significance difference in Physiological variables between Ball game(Handball) and Racket game(Badminton) players. Insignificant differencewas to find in physical variables between Ball game(Handball) and Racket game(Badminton)players.
Los impactos sociales de la pandemia causados por el SARS-CoV-2 en México
Authors: Ramírez Sánchez Rubén Darío , Chávez Jiménez Daniar
Published: August 2023

El presente escrito tiene como objetivo central estudiar los efectos que la pandemia (causados por el SARSCoV-2) está ocasionando en la sociedad mexicana. Dentro de un contexto marcado por una crisis generalizada, originada por el modelo capitalista neoliberal, los hábitos de consumo mundial y los impactos negativos del deterioro ambiental a nivel planetario, nos proponemos revisar el material bibliográfico relacionado con la crisis sanitaria. El estudio analiza algunos efectos económicos y sociales de la pandemia, así como las nuevas convivencias basadas en la solidaridad y la comunalidad. De igual forma, reflexionamos sobre el papel del Estado ante la emergencia sanitaria. Finalmente, se analiza cuál será la función que deberá desempeñar la educación en la postpandemia.
Conocimientos, actitudes y prácticas respecto al dengue en familias de la comuna uno, Villavicencio – Colombia
Authors: Hernández Cristancho Leidy Johanna , Salamanca Ramos Emilce
Published: August 2023

Fundamentos: el dengue es una enfermedad transmitida por un vector presente en regiones tropicales y que ha tenido un aumento de casos a nivel mundial. El objetivo fue determinar el nivel de conocimientos, actitudes y prácticas que tienen las familias sobre el dengue en un sector de la ciudad de Villavicencio, Colombia. Métodos: estudio cuantitativo, observacional descriptivo, transversal. Muestreo probabilístico bietápico y estratificado, con n = 306 familias. Instrumento encuesta sociodemográfica, instrumento Conocimientos Actitudes y Practicas validado para Colombia. Análisis con estadística descriptiva y de correspondencia múltiples, procesamiento de información por SPSS Vr.22. Resultados: sexo: predomina mujeres (65 %), la edad promedio 47 años, en promedio 4 habitantes por vivienda, nivel de escolaridad básica secundaria finalizada (28,1 %), técnico (13,1 %) universitario (18 %). Conocimiento del dengue, indicaron que era una enfermedad muy grave (84 %), que era transmitida por un zancudo (37,6 %) y que el síntoma principal era fiebre (89,9 %). Realizaban medidas de prevención como fumigar (14,9 %), lavar el tanque una vez por semana (39,9 %), cuando las personas se enferman de dengue reconocían la principal actividad como llevarlos al médico (58,2 %), se encontró que en un 3,2 % de la población se presentaron casos de dengue, hay correspondencia entre mayor estudio y nivel socioeconómico, mejores conocimiento y control de la enfermedad en las familias. Conclusiones: las familias tienen los conocimientos necesarios para emplear medidas de prevención, pero no tienen actitudes frente a la enfermedad y no realizan las prácticas suficientes para lograr prevenirlo.
Apoyos sociales de las familias campesinas para mantener la salud
Authors: Orozco Castillo Liliana , Betancurth Loaiza Diana Paola , Giraldo-Osorio Alexandra
Published: August 2023

Introducción: las familias campesinas poseen apoyos sociales en varias dimensiones que proporcionan bienestar familiar. El objetivo fue comprender los apoyos sociales que tienen las familias campesinas del municipio de Villamaría (Caldas, Colombia) para mantener la salud. Método: etnografía interpretativa, muestreo intencional con observación participante y entrevistas etnográficas a siete familias de cinco veredas de la zona rural. Se realizaron 29 visitas familiares entre septiembre de 2017 y noviembre de 2018. Análisis en cuatro fases en espiral propuesto por McFarland y Leininger, con el apoyo del software Atlas ti. Resultados: los soportes sociales que las familias campesinas consideran importantes para mantener su salud se condensan en un patrón de carácter holístico denominado “sobrevivimos gracias a la familia, los vecinos, el trabajo, “Dios”, y quienes nos ayudan”. Demuestran heterogeneidad y son fundamentales para el mantenimiento de la salud familiar. Conclusiones las redes de apoyo social de las familias campesinas se constituyen como elementos diversos y necesarios para mantener la salud familiar, lo que motiva a los profesionales de la salud a trascender las atenciones enfocadas en el proceso salud–enfermedad.
Memoria del pasado reciente en la escuela: una perspectiva desde las alfabetizaciones múltiples
Authors: Amador Baquiro Juan Carlos
Published: August 2023

La pedagogía de la memoria del pasado reciente es un campo epistémico que orienta procesos de formación para la construcción de subjetividades políticas que aporten a la restauración de la dignidad de quienes han sido víctimas de hechos atroces y a la problematización de los puntos de vista de diversos actores de la sociedad, quienes desde el presente interrogan el pasado con base en diferentes propósitos. En este trabajo se expondrán los aportes del enfoque denominado alfabetizaciones múltiples al campo de la pedagogía de la memoria, dado que este pretende que los estudiantes adquieran capacidades para leer críticamente los medios de comunicación, así como crear textos multimodales en torno a la realidad del presente y el pasado. De acuerdo con esto, en la primera parte se presentan los presupuestos del campo de la pedagogía de la memoria del pasado reciente y del enfoque de las alfabetizaciones múltiples. Posteriormente, se presentan las estrategias educativas que permiten abordar la memoria del pasado reciente con los estudiantes a partir de dos tipos de alfabetización: informacional–digital y mediática. Al final se presentan las conclusiones.
Un acercamiento a los liderazgos femeninos en torno a la construcción de paz
Authors: Bonilla Montenegro Daniel Andrés , Pardo Parra Luisa Fernanda
Published: August 2023

El liderazgo es un concepto que ha trascendido en diferentes contextos, lo que ha permitido que se extienda su aplicación a diferentes disciplinas y campos aplicados dentro de las ciencias sociales. Reconociendo una serie de características y roles que no solo impactan las organizaciones, sino que se relacionan con procesos políticos y sociales, además se percibe un gran desarrollo de las teorías y conocimientos sobre el liderazgo desde una perspectiva mayoritariamente masculina. El presente artículo tiene como objetivo reconocer las experiencias de mujeres que han ejercido procesos de liderazgo que han contribuido a la paz. Lo que permite proponer la necesidad de generar estrategias alternativas de comprensión de estos fenómenos en relación con los procesos participativos, el liderazgo, las contribuciones frente a la construcción, la acción y el mantenimiento de la paz fuertemente vinculado al trabajo de las mujeres en diferentes ámbitos de la sociedad.
La internacionalización de la investigación en países emergentes: perspectivas de gestores de internacionalización en Colombia
Authors: Lafont Castillo Tania Isabel , Echeverría King Luisa , De Luque Montaño Olisney , Álvarez Ruíz Liliana Patricia , Lozada Cantillo Andrea
Published: August 2023

La internacionalización de la investigación se ha convertido para los países emergentes en una herramienta de cara al desarrollo de sus capacidades en ciencia, tecnología e innovación. Esta investigación buscó comprender cómo se gestionan los procesos de internacionalización de la investigación desde una perspectiva de gestores de la internacionalización de universidades colombianas, con el fin de exponer implicaciones para el desarrollo de este tema en países emergentes. Para esto, se realizó un grupo focal cuyos datos fueron analizados con el análisis cualitativo de contenido. Se debe trabajar en la construcción de capacidades para poder gestionar proyectos transnacionales. En Latinoamérica el bilingüismo es un reto, también la falta de competencias para publicar en revistas de impacto y la administración de recursos de la cooperación internacional. Para avanzar, las instituciones deben alinear los intereses de investigación con problemas trasnacionales, crear equipos internos de trabajo y realizar seguimientos y mediciones de impacto.
Métodos y técnicas empleados en investigaciones teológicas latinoamericanas publicadas entre 2018 y 2020
Authors: Cardozo Juan Felipe , Rúa Penagos Jonathan Andrés
Published: August 2023

El objetivo de este trabajo fue analizar cuantitativamente los métodos y técnicas de la investigación teológica en países latinoamericanos de habla hispana, entre 2018 y 2020, para el fomento de herramientas que favorezcan estudios en el área. El estudio fue cuantitativo, positivista y descriptivo, examinando el Scimago Journal & Country Rank (SJR) 2018, revisando, además, artículos publicados entre 2018 y 2020, nueve publicaciones de universidades que ofrecen el programa Teología, trabajos de grado y tesis en repositorios digitales. Para un total de 402 investigaciones sistematizadas, usando el análisis de contenido para discriminar métodos y técnicas utilizados. La información se registró en una matriz para su análisis porcentual por criterios. Se concluye que una quinta parte de las investigaciones usaron exclusivamente métodos sociales, en su mayoría de enfoque cuantitativo y nivel descriptivo. Entre los sociales cualitativos destacaron la fenomenología, IAP, método comparativo y biográfico. Se usaron mayoritariamente métodos teológicos tradicionales: hermenéutico, exegético, praxeológico latinoamericano e histórico-crítico, pero el primero sigue siendo preferido. Las técnicas fueron variadas, mezclando enfoques y métodos, especialmente reflexión, análisis semántico, análisis histórico-gramatical y narración. De las técnicas sociales, la favorita fue encuesta-cuestionario. El país con más publicaciones fue Colombia (45,7 %) y el año con mayor número de estas fue el 2018 (55 %). El enfoque predilecto fue cualitativo (87,1 %), usado mayoritariamente en universidades católicas (78,6 %). El resto (21,4 %) corresponde a universidades adventistas, con más igualdad en los enfoques.
Los jesuitas y la Iglesia con rostro indígena
Authors: López Arcos Armando
Published: August 2023

En las últimas décadas un sector de la Iglesia católica latinoamericana ha impulsado la idea de conformar una Iglesia con rostro indígena, en la cual los indígenas se incorporen a la estructura eclesiástica a través de algunos cargos como catequista o diácono. Algunos incluso han propuesto la ordenación de sacerdotes indígenas que, de acuerdo a la cosmovisión de los indígenas, deben ser casados.
El presente artículo tiene el objetivo revisar, desde la perspectiva de la historización de los conceptos propuesta por Ellacuría, el aporte teóricopráctico realizados por la Compañía de Jesús, en particular tres religiosos ignacianos —Xavier Albó, Manuel Marzal y Bartomeu Melià— a dicho proceso. Como se verá a lo largo del texto, ha sido un camino lleno de avances y retrocesos. En el ámbito teórico, los jesuitas han defendido la idea de que la inculturación es el mejor camino para que la Iglesia logre una verdadera inserción en la realidad de las comunidades indígenas. En el terreno práctico se explora la experiencia de los diáconos indígenas en dos regiones: en la zona aymara de los Andes —especialmente en Bolivia— y en la Misión de Bachajón, Chiapas. Ambas experiencias con resultados disimiles, pero que enriquecen el caminar de la Iglesia con rostro indígena.
Aparecer, sentido y objetividad. A propósito del debate reciente sobre realismo, fenomenología y hermenéutica
Authors: Grasset Bautista Jean-Paul
Published: August 2023

El objetivo de este artículo es abordar el reciente problema del nexo entre realismo y fenomenología hermenéutica desde un enfoque específico: el diálogo entre el nuevo realismo de Markus Gabriel y algunas propuestas hermenéutico-fenomenológicas alemanas que se autocomprenden en términos realistas. Afirmo la hipótesis de que es posible un diálogo productivo entre estas propuestas, basado en una comprensión mínima del realismo como fundamentación ontológica viable. Para esto, en primer lugar mostraré el sentido del actual resurgimiento del realismo en el contexto de la ontología continental contemporánea, situando su recepción, crítica e integración a propósito del ámbito de la fenomenología y hermenéutica recientes. En segundo lugar, analizaré la propuesta de nuevo realismo, que está implicada en la ontología de campos de sentido de M. Gabriel. Y, en tercer lugar, reseñaré las propuestas de Günter Figal, Anton Friedrich Koch y Tobias Keiling en su fundamento realista. Mediante este trabajo comparativo, concluiré afirmando que el diálogo entre ambas corrientes comparte una comprensión realista no reductiva a la cuestión del mundo exterior, que le permite entenderlo como búsqueda de cierto criterio de objetividad para lo que aparece sensiblemente con sentido, con el propósito de esclarecer por qué las cosas reales son dependientes de la interpretación (interpretables en general), pero independientes de interpretaciones individuales.
Examining the Social Acceptance Levels of Teachers towards Individuals with Special Needs
Authors: AKTAN Osman
Published: August 2023

Introduction: The positive approach of the teacher towards individuals with special needs, his participation in the educational processes with his peers, and the teacher's attitudes and behaviors such as supporting both the academic and social development of the individual with special needs affect the social acceptance of the individual with special needs positively.
Method: This study, investigating the social acceptance levels of teachers towards the individuals with special needs in terms of various variables, was a descriptive study and designed as a screening model. The data of the study were obtained from 1433 teachers working in different education levels (preschool, primary school, secondary school and high school) in the central district of Düzce province and determined by the easily accessible case sampling method.
Findings: According to the research findings, among teachers' social acceptance levels for individuals with special needs; It was determined that there was a significant difference in terms of gender, whether there were individuals with special needs in the family and close environment, whether there were individuals with special needs in the teachers' classrooms, and the belief that inclusive practices were an effective model. In addition, among teachers' social acceptance levels for individuals with special needs; It was determined that there was a significant difference according to the disability type of individuals with special needs, their participation in professional development activities for inclusion practices, their education level and professional seniority variables.
Discussion: In the study, it was determined that teachers' beliefs about inclusion practices, their professional development and professional seniority were effective on their social acceptance of individuals with special needs. It was determined that teachers with special needs in their class had lower social acceptance scores. Based on these findings, it is recommended to organize in-service training activities and to benefit from the mentorship of experienced teachers in order to improve the professional competence of teachers for inclusion practices. In addition, it is recommended to conduct qualitative research in order to obtain in-depth information about the variables that show a significant difference in terms of teachers' social acceptance levels for individuals with special needs.
Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular
Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF
Signalling Pathway
Authors: Malami Ibrahim , Alhassan Alhassan Muhammad , Adamu Adamu Ahmed , Bello Muhammad Bashir , Muhammad Aliyu , Imam Mustapha Umar
Published: August 2023

Background:

Hepatocellular carcinoma (HCC) is associated with a high mortality rate
due to early recurrence and its metastasis features. To this day, effective treatment options for metastatic
HCC remain a major challenge to patient treatment. Flavokawain B (FKB) is a naturally occurring
chalcone molecule capable of providing effective therapy against this life-threatening disease.

Objective:

This study investigated the anti-metastatic effects of FKB on the growth and development
of metastatic HCC.

Methods:

HepG2 cells were used in this study and a neutral red assay was performed to determine
the IC50 value of FKB. Cell scratch and exclusion zone assays were performed to assess the rate of
cell migration and invasion. Relative mRNA levels of UCK2, STAT3, VEGF and HIF-1α genes
were quantified using RT-qPCR.

Results:

FKB inhibited the proliferation of HepG2 cells at an IC50 value of 28 μM after 72 h of incubation.
Its cytotoxic effect was confirmed to induce apoptosis through the phase-contrast inverted
microscope. Cell migration and invasion were significantly inhibited at 7, 14, and 28 μM of
FKB as compared to untreated cells. The inhibition in the cell migration significantly increased
with the increasing concentrations of the bioactive compound. The relative expression levels of the
UCK2 gene and its downstream genes, STAT3, VEGF and HIF-1α, were significantly downregulated
after 72 h exposure to FKB treatment.

Conclusion:

Our data suggest that FKB inhibited HepG2 proliferation and further suppressed its
metastasis partly by regulating the STAT3/Hif-1α/VEGF signalling pathway. FKB could be a potential
alternative and viable strategy against HCC.
Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells
by Inhibiting NRP-1
Authors: Yang Hongqiong , Zhou Yaojun , Wang Liangzhi , Lv Mengjia , Sun Jinling , Luo Zhenguo , He Junbo
Published: August 2023

Aims and objectives:

Semaphorin3A (Sema3a) is lowly expressed in the
peripheral blood of gastric cancer patients, suggesting Sema3a may be involved in the
progression of gastric cancer. Nevertheless, the specific role and the potential regulatory
mechanism of Sema3a in gastric cancer is still obscure. Neuropilin-1 (NRP-1) has been
reported to interact with Sema3a; herein, we intended to reveal the role and regulatory
mechanism of Sema3a/neuropilin-1 (NRP-1) in gastric cancer progression.

Methods:

Cell transfection was carried out to regulate gene expression. CCK-8 and
colony formation assays were applied to estimate cell proliferation. Scratch assay and
transwell assay were conducted to assess the cell migration and invasion abilities.
Angiogenesis ability was assessed using a tubule-forming assay. The expression of
corresponding genes and proteins were detected by RT-qPCR and western blot,
respectively.

Results:

Data showed that Sema3a was downregulated in gastric cancer cells and
NRP-1 was upregulated. Sema3a overexpression repressed NRP-1 level in AGS cells.
Overexpression of Sema3a inhibited cell proliferation, migration, and invasion abilities as
well as epithelial-mesenchymal transition (EMT) of AGS cells. Overexpression of
Sema3a inhibited tube formation and reduced the expression of VEGFA/VEGFR2 in
AGS cells. However, the effects of Sema3a overexpression on the malignant behaviors
in AGS cells were partly reversed by NRP-1 overexpression. Additionally, Sema3a
overexpression enhanced the inhibitory effects of Ramucirumab, an anti-VEGFR2 agent,
on the proliferative, migratory, and invasive capabilities as well as EMT in AGS cells.

Conclusion:

In conclusion, Sema3a alleviates the proliferation, migration, invasion, and
angiogenesis capabilities of gastric cancer cells via repressing NRP-1. This finding may
provide potential targets for gastric cancer therapy.
Case Report and Literature Review of Multi-drugs Synergy and Targeted
Comprehensive Treatment in Advanced Hepatocellular Carcinoma
Authors: Lu Guanhua , Ou Limin , Cao Mingrong , Hu Min
Published: August 2023

Background:

A 43-year-old female patient was found to have an abnormal liver function,
abnormally elevated alpha-fetoprotein and space-occupying lesions in the liver on routine
screening. The patient came to our hospital for further diagnosis and treatment.

Case presentation:

Investigations: Laboratory investigations, digital subtraction angiography (DSA)
of the hepatic artery, abdominal ultrasound examination, and magnetic resonance imaging (MRI)
scan were conducted using pathological staining and immunohistochemistry. Diagnosis: Clinical
diagnosis: cT3NxM0. Barcelona clinic liver cancer (BCLC) staging: BCLC stage C. China liver
cancer (CNLC) staging: CNLC IIIa.

Discussion:

The patient was hospitalized for the first time for transcatheter arterial chemoembolization
(TACE) and FOLFOX-based hepatic arterial infusion chemotherapy (HAIC). Then, the second
and third hospital admissions were given HAIC based on FOLFOX. Camrelizumab and oncolytic
virus were also injected into the liver cancer through the microcatheter in the first three treatments.
On the fourth admission, the patient’s indicators were improved, and the tumor shrank. Furthermore,
as the patient suffered adverse reactions the first few times, we suspended the treatment
of FOLFOX and the oncolytic virus. Before surgical treatment, lenvatinib was used throughout the
treatment. On the fifth admission, the patient underwent liver cancer resection.

Conclusion:

It proves the value of multiple combination therapy, which can provide guidance for patients with advanced hepatocellular carcinoma that cannot be surgically removed.
Effects of Antidepressants on Sleep in Post-traumatic Stress Disorder: An
Overview of Reviews
Authors: Lappas Andreas S. , Polyzopoulou Zoi A. , Christodoulou Nikos , Bozikas Vasilios-Panteleimon , Samara Myrto T.
Published: August 2023

Antidepressants are a commonly used, easily accessible, and overall safe treatment option
for post-traumatic stress disorder (PTSD). The present review aims to evaluate the efficacy and safety
of antidepressants in treating sleep disturbances in patients with PTSD. PubMed and the Cochrane Library
were searched (July 2022) for systematic reviews and meta-analyses on the treatment of PTSD.
Moreover, PubMed and ClinicalTrials.gov were searched for individual trials investigating the antidepressant
treatment of PTSD (up to September 2022), and reference lists of all possibly relevant identified
studies were screened. Sleep-related outcomes, i.e., total sleep time, sleep quality, dreams/
nightmares, insomnia, and somnolence, were extracted independently by at least two reviewers. Metaanalytic
evaluations were performed wherever possible. 39 randomised controlled trials (RCTs) were
identified; data from pooled analyses, reviews, and observational studies were used for antidepressants
with a weak evidence base or when their findings were deemed important. Overall, scarce data exist
on the effects of antidepressants on sleep outcomes among patients with PTSD. Some evidence may
support the use of amitriptyline, nefazodone, paroxetine, and sertraline for improving sleep in patients
with PTSD. Τhere was a meta-analytical trend indicating improvement of nightmares with fluoxetine,
less insomnia with amitriptyline and more with brofaromine, as well as more somnolence with paroxetine
vs. placebo, respectively. However, data from more than 1 RCT with a considerable number of patients
were only available for paroxetine. Evidence is insufficient to draw safe conclusions. More and
better-designed RCTs, with consistent reporting of sleep-related outcomes, are needed.
Enantioselective Michael Addition of Cyclohexanone to Nitroolefins
Catalyzed by a New Pyrrolidinyl-isosteviol Bifunctional Organocatalyst in
Water
Authors: Liu Yu-Xia , Xu Yuan-Yuan , Li Shuai , Pan Zi-Qing , Li Bing-Xue , Fan Zhao-Yang
Published: August 2023

A new pyrrolidinyl-isosteviol bifunctional organocatalyst was synthesized, which was applied
to catalyze the asymmetric Michael addition between cyclohexanone and nitroolefins. With 10
mol % of the organocatalyst, the reaction proceeded in water in high yields (up to 99%) with excellent
diastereoselectivities (anti/syn up to 98:2) and good enantioselectivities (up to 90% ee). The design of
the proline-isosteviol conjugates as organocatalysts was based on the crucial role of proline in the
formation of enamine. To sum up, a new pyrrolidinyl-isosteviol bifunctional organocatalyst was synthesized,
which could effectively catalyze the C-C formation reaction between a number of nitroolefins
and cyclohexanone.
Exploring Novel PLK1 Inhibitors based on Computational Studies of
2,4-Diarylaminopyrimidine Derivatives
Authors: Yang Honghao , Zhao Yilan , Zheng Xiaojiao , Ju Xiulian , Wu Fengshou , Luo Xiaogang , Sun Qi , Liu Genyan
Published: August 2023

Background:

Polo-like kinase 1 (PLK1) is an important target for anti-cancer drugs. A series
of novel 2,4-diarylaminopyrimidine derivatives (DAPDs) as PLK1 inhibitors (PLKIs) with remarkable
activities have been reported recently.

Methods:

A systemically computational study was performed on these DAPDs, including threedimensional
quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and
molecular dynamics (MD) simulation.

Results:

The constructed 3D-QSAR models exhibited reliable predictability with satisfactory validation
parameters. The dockings revealed the binding modes of DAPDs in PLK1 protein, and two key residue,
Cys133 and Phe183, could interact with DAPDs by hydrogen bonds and π-π stacking, which might be
significant for the activity of these PLKIs. Eight compounds with higher predicted activity than the most
active DAPD-compound (16) were designed based on the 3D-QSAR models. These newly designed compounds
also exhibited higher docking scores than compound 16 in the binding pocket of PLK1. The
ADME predictions and MD simulations further indicated that two hit compounds with reasonable pharmacokinetics
properties could stably bind with PLK1 and have the potential to become novel PLKIs.

Conclusion:

Two newly designed compounds might have the potential to be novel PLKIs. These results
might provide important information for the design and development of novel PLKIs.
Efficacy of Osimertinib Continuation Plus Metronomic Oral Vinorelbine for EGFRmutant
Advanced NSCLC Beyond Limited Progression on Osimertinib
Authors: Li Meifang , Lin Cheng , Lin Jinghui , Chen Shijie , Weng Lihong , He Zhiyong
Published: August 2023

Background:

Treatment options for advanced non-small-cell lung cancer (NSCLC) after osimertinib failure
are limited, and osimertinib continuation is recommended for selected patients. Metronomic oral vinorelbine is an
effective treatment with less toxicity for advanced NSCLC.

Objective:

The objective of the study was to investigate the effects of osimertinib plus metronomic oral vinorelbine on
epidermal growth factor receptor (EGFR)-mutant advanced NSCLC beyond limited progression on osimertinib.

Methods:

We have reviewed the medical records of 28 patients with EGFR-mutant advanced NSCLC who had received
osimertinib continuation plus metronomic oral vinorelbine beyond limited progression on osimertinib. We also
evaluated the clinicopathological characteristics of enrolled patients, as well as the efficacy and toxicity of the treatment

Results:

After a median follow-up period of 14.1 months, 57.1% (16/28) of cases showed NSCLC progression. The
median progression-free survival (PFS) period under osimertinib plus metronomic oral vinorelbine was 9.4 months
(95% confidence interval, 1.562–17.238 months), with a disease control rate of 89.3% and objective response rate of
17.9%. PFS did not differ between patients who had previously received osimertinib as first- (n = 16) and second-line
(n = 12) therapy (median, 11.4 and 4.7 months, P = 0.391). In addition, the median PFS duration did not differ according
to the efficacy (PFS2 ≥ 6 months vs. < months) of previous osimertinib monotherapy (median, 5.8 and 9.4
months, P = 0.677).

Conclusions:

Osimertinib continuation in conjunction with metronomic oral vinorelbine may enable overcoming TKI
resistance and prolong the survival of patients with EGFR-mutant advanced NSCLC beyond limited progression on
osimertinib treatment
A Study on Psychological Impact of Working From Home of Employees during COVID-19 Pandemic- a Cross Sectional Study
Authors: Dondapati Sumedha , S. Iniyan , B. Ajay , R. Maathanghi , P. Kavitha
Published: August 2023

Introduction:

With the sudden onset of COVID 19, many organisations introduced
a mandatory relocation of workforce from their workplace to their homes bringing in a work
from home policy for their employees. The purpose of the study is to examine the positive and
negative impact on quality of life of teleworking, thereby assessing the prevalence of psychological
distress of employees working in COVID 19.

Methods:

A cross sectional study was conducted on Indian - representative survey of selfreported
data through an online questionnaire of work from home employees and their responses
were analysed using SPSS software.

Results:

The study findings revealed that out of 2943 total respondents to the questionnaires,
18.9% and 20.2% had agreed and strongly agreed respectively to the statement that, work from
home was a chance to break old habits and change routine. The mean positive affect score
among those affected with COVID was 20.82 ± 3.71 and for those not affected with COVID
was 21.12 ± 3.71.

Conclusion:

The results indicate age disparities in mental distress, perceived adversities highlighted
the discrepancies differed by the area of residence and those affected by the corona virus.
Does COVID-19 pandemic moderate financial leverage, firm size, and dividend pay-out ratio on systematic risk (beta) of stock?
Authors: Mahendra I Kadek Rian , Suaryana I Gst. Ngr. A.
Published: August 2023

The purpose of this study was to obtain empirical evidence regarding the effect of financial leverage, firm size, and dividend payout ratio on the systematic risk (beta) of stocks with the Covid-19 pandemic as a moderating variable. The data used is secondary data obtained from annual reports of LQ-45 index companies listed on the Indonesia Stock Exchange during the 2018-2022 period. The data analysis technique used was the sub-group moderation. The total population in this study was 45 companies listed in the LQ-45 index, using the purposive sampling method, where 115 observations were obtained. The research results show that: 1) financial leverage has a positive effect on the systematic risk (beta) of stocks; 2) firm size has no effect on the systematic risk (beta) of stocks; 3) dividend payout has a negative effect on the systematic risk (beta) of stocks; 4) the COVID-19 pandemic strengthened the effect of financial leverage on the systematic risk (beta) of stocks; 5) the COVID-19 pandemic was unable to moderate the effect of firm size on the systematic risk (beta) of stocks; and 6) the COVID-19 pandemic strengthened the effect of the dividend payout ratio on the systematic risk (beta) of stocks.
Properties of Vietnamese water caltrop starch and formation of low glycemic index starch
Authors: Trinh Khanh Son , Nguyen Thuy Linh , Dang-Thi Thanh-Hoa
Published: August 2023

This research investigates the properties and modification of water caltrop starch (WCS) with a particular focus on its potential for retrogradation and resistance to enzymatic hydrolysis. The study begins by obtaining WCS with a recovery efficiency of 4.5% (w/w in dry basis). The native WCS exhibits notable characteristics, including an apparent amylose content of 45.4%, a ratio of amorphous/α-helix regions at 1.341, a degree of relative crystallinity of 54.43%, an average molecular weight of 6.58×104 g/mole, and a degree of polymerization of 365.57. The high amylose content and degree of crystallinity in native WCS indicate its favorable retrogradation potential and resistance to enzymatic hydrolysis. Textural analysis of the WCS gel reveals high hardness and chewiness but low adhesiveness, which further supports its potential for retrogradation applications. To explore the effects of repeated retrogradation cycles, native WCS was subjected to 3, 6, and 9 cycles. The increase in retrogradation cycles led to a decrease in apparent amylose content from 31.79% to 29.34%. This reduction can be attributed to the formation of double helix associations and the emergence of new crystalline regions from amylose molecules. Furthermore, an increase in retrogradation cycles resulted in enhanced syneresis of starch. Interestingly, as the number of retrogradation cycles increased, the enzymatic hydrolysis rate of retrograded WCS gradually decreased. Correspondingly, the estimated glycemic index (GI) of the samples decreased, reaching a range of 50.05 to 38.46. Consequently, treatment with repeated retrogradation proves to be an effective strategy for producing modified WCS with a low glycemic index (<50%), thereby presenting promising opportunities for low glycemic index applications.
Investigating the Effect of Satisfaction toward Self-Service Technology (SST) and Behavioral Intention Relationship: Its role in the green hotel industry
Authors: Hamid Rasidah , Azman Ong Mohd Hanafi , Kusumah Galih
Published: August 2023

Today's hotels are deploying self-service technologies (SSTs) to allow efficient and effective service delivery. SST significantly impacts customers' interaction with service providers. Through the survey, this study explores the relationship between SST and customer behavioural intention via customer satisfaction for Malaysia's green hotel industry. Data from 431 respondents were analysed using structural equation modelling with the partial least squares approach. The findings showed customer satisfaction mediated the association between SST and customer behavioural intention. This finding would help the green hotel's managers to focus on SST which could boost customer satisfaction and indirectly improve the likelihood of positive behavioural intention.
Study of Current Trends of Participation of Population of the BRICS and OECD Countries in the Global Online Labor Market
Authors: Galieva G. F. , Sazanova E. V. , Dik E. N. , Amineva R. R.
Published: August 2023

The relevance of the study is the need to study current trends in the global online employment market in developed and developing countries in order to level out possible imbalances in the labor market in the context of digital development.

The purpose of the study is to conduct a comparative analysis and identify the features of the participation of the population of the BRICS and OECD countries in the functioning of the global online labor market at the present stage, as well as to determine measures to ensure the balanced development of the traditional labor market in the implementation of new forms of online employment.

The objectives of the study are to identify the level of formation of the basic conditions for the access of the population of some BRICS and OECD countries to the global online labor market; to determine trends in the participation of the population of the BRICS and OECD countries in the global online labor market; to form recommendations to ensure the balanced development of the traditional market in the conditions of the activation of the online labor market.

Methodology. The study was conducted using the method of content analysis of information from open sources, methods of comparative and economic analysis. The results of data analysis are presented using systematization methods, tabular and graphical methods. The formation of recommendations is provided by the use of the logical method, as well as analysis and synthesis.

Results. The gap in the level of formation of basic conditions for access to digital infrastructure between the BRICS and OECD countries has been revealed, which determines their differences in the use of the potential of the global online labor market. It has been established that the global online labor market is generally more preferable for employers from developed OECD countries and specialists from developing BRICS countries. The directions of expanding the possibilities of using the potential of the global online labor market for the BRICS and OECD countries are substantiated.

Conclusion. The analysis confirmed the authors' assumption that there are significant differences between developed and developing countries in using the potential of public participation in the global online labor market.
Financial Management of an Industrial Enterprise in the Context of Digital Transformation
Authors: Krilova V. V.
Published: August 2023

Relevance. Development of industrial enterprise changes constantly. It’s apparented in the different information technologies introduction. It’s let to participate in the digital economy project on the national and international market. Different changes in the industrial enterprise activities indicate in changes of financial recourses management in current time period and in perspective.

The purpose is studying financial resources management in the industrial enterprise in digital transformation’s realization in current time period and in perspective. 

Objectives. Research objectives include studying kinds of financial recourses and their changes in the industrial enterprise; studying financial recourses management features in the industrial enterprise in digital transformation’s realization; forming digital transformation strategy stages in this enterprise and their impact on financial recourses.

Methodology. It’s researched financial recourses management features in the industrial enterprise and their changes in digital transformation’s realization in current time period and in perspective for achieving the set goal. 

Results. It’s studied financial management features in the industrial enterprise. It’s researched features of digital transformation’s realization in the industrial enterprise for participating in digital economy. It’d formed features of financial management in the industrial enterprises in terms of digital transformation’s realization in current time period and in perspective. 

Conclusions. Financial management in terms of digital transformation let to accelerate different processes realization, to increase efficiency of this enterprise activities in the national and international market. It let to support desired level of this enterprise competitiveness.