bluuebunny/crossref_metadata_2025 huggingface dataset:
A systematic review and meta-analysis comparing the impact of tenofovir and entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma patients undergoing liver resection
Authors: Hu Lingbo , Yang Chao , Qiao Yingli , Wang Aidong
Published: July 2024

Background

Tenofovir (TDF) and entecavir (ETV) are highly effective and well-tolerated nucleos(t)ide analogs commonly prescribed for hepatitis B virus (HBV) treatment. Yet, it is unclear whether survival outcomes differ for HBV-related hepatocellular carcinoma (HCC) patients treated with ETV and TDF. Thus, this meta-analysis aimed to compare the prognostic effectiveness of ETV and TDF in HBV-related HCC patients.

Methods

We comprehensively searched four databases, PubMed, Web of Science, Embase, and the Cochrane Library, to identify pertinent studies utilizing keywords “entecavir,” “tenofovir,” “hepatocellular carcinoma,” and “liver resection.” Our primary outcomes of interest encompassed overall survival (OS), recurrence-free survival (RFS), early recurrence, and late recurrence. The statistical effect size for these measures was expressed in terms of hazard ratios (HRs).

Results

Our search yielded 10 studies encompassing 11 datasets involving 7,400 patients. Our meta-analysis revealed that patients treated with TDF achieved better OS (HR = 0.53; 95% confidence interval [CI] = 0.40–0.70, p < 0.0001), RFS (HR = 0.68; 95% CI = 0.57–0.80; p < 0.0001), early recurrence (HR = 0.80; 95% CI = 0.67–0.94; p < 0.0077), and late recurrence (HR = 0.64; 95% CI = 0.43–0.97; p = 0.0368). We detected publication bias potentially affecting OS but not RFS.

Conclusion

Our findings demonstrated that TDF outperformed ETV regarding RFS for HBV-related HCC patients. However, to bolster the evidence and establish more conclusive conclusions, further validation via extensive and high-quality randomized controlled trials is essential.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD 42024542579.
Pictures versus words: can we use a pictorial scale to measure child health-related quality of life?
Authors: Tang Tracy Chor Wai , Wong Mun , Li Jian-Bin , Chan Derwin King Chung
Published: July 2024

Measuring health-related quality of life (HRQoL) is important because it can serve as an indicator or a predictor of subsequent mortality or morbidity. HRQoL has been shown to be directly related to child growth and development and indirectly related to the healthcare costs of young children. Existing measures of HRQoL in children have heavily relied on traditional questionnaires that use age-suited versions or parent proxy questionnaires. However, both of these methods may present with different types of biases and may misrepresent underlying HRQoL. The current mini reivew will first illustrate these methodological limitations and highlight the potential use of pictorial scales in addition to discussing their suitability for specifically measuring HRQoL as an alternative. We will also synthesize existing recommendations on the development of pictorial scales to provide a protocol as a recommendation to researchers who are aiming to develop an overall HRQoL pictorial scale that is suited for children.
Effectiveness of engaging religious leaders in maternal health education for improving maternal health service utilization in Ethiopia: cluster randomized controlled trial
Authors: Sadore Abinet Arega , Kebede Yohannes , Birhanu Zewdie
Published: July 2024

Introduction

High mortality rates for pregnant women and their new-borns are one of Africa’s most intractable public health issues today, and Ethiopia is one of the countries most afflicted. Behavioral interventions are needed to increase maternal health service utilizations to improve outcomes. Hence, this trial aimed to evaluate effectiveness of trained religious leaders’ engagement in maternal health education on maternal health service utilization.

Methods

The study employed a cluster-randomized controlled community trial that included baseline and end-line measurements. Data on end points were gathered from 593 pregnant mothers, comprising 292 and 301 individuals in the intervention and control groups, respectively. In the intervention group, the trained religious leaders delivered the behavioral change education on maternal health based on intervention protocol. Unlike the other group, the control group only received regular maternal health information and no additional training from religious leaders. Binary generalized estimating equation regression analysis adjusted for baseline factors were used to test effects of the intervention on maternal health service utilization.

Results

Following the trial’s implementation, the proportion of optimal antenatal care in the intervention arm increased by 21.4% from the baseline (50.90 vs. 72.3, p ≤ 0.001) and the proportion of institutional delivery in the intervention group increased by 20% from the baseline (46.1% vs. 66.1%, p ≤ 0.001). Pregnant mothers in the intervention group significantly showed an increase of proportion of PNC by 22.3% from baseline (26% vs. 48.3%, p ≤ 0.001). A statistically significant difference was observed between in ANC4 (AOR = 2.09, 95% CI: 1.69, 2.57), institutional delivery (AOR = 2.36, 95% CI: 1.94, 2.87) and postnatal care service utilization (AOR = 2.26, 95% CI: 1.79, 2.85) between the intervention and control groups.

Conclusion

This research indicated that involving religious leaders who have received training in maternal health education led to positive outcomes in enhancing the utilization of maternal health services. Leveraging the influential position of these religious leaders could be an effective strategy for improving maternal health service utilization. Consequently, promoting maternal health education through religious leaders is advisable to enhance maternal health service utilization.

Clinical trial registration: [https://clinicaltrials.gov/], identifier [NCT05716178].
Advancing longevity research through decentralized science
Authors: Unfried Maximilian
Published: July 2024

In an era marked by scientific stagnation, Decentralized Science (DeSci) challenges the inefficiencies of traditional funding and publishing systems. DeSci employs blockchain technology to address the misalignment of incentives in academic research, emphasizing transparency, rapid funding, and open-source principles. Centralized institutions have been linked to a deceleration of progress, which is acutely felt in the field of longevity science—a critical discipline as aging is the #1 risk factor for most diseases. DeSci proposes a transformative model where decentralized autonomous organizations (DAOs) facilitate community-driven funding, promoting high-risk, high-reward research. DeSci, particularly within longevity research, could catalyze a paradigm shift towards an equitable, efficient, and progressive scientific future.
Child-centered home service design for a family robot companion
Authors: Lym Hyo Jeong , Son Hyo In , Kim Da-Young , Kim Juhyun , Kim Min-Gyu , Chung Jae Hee
Published: July 2024

The home robot-based child activity service aims to cultivate children’s social emotions. A design theme was produced by interviewing child development experts and parents. The activity service is composed of 50 plays and 70 conversations. These were developed based on activities from psychomotor therapy and the guidelines of Ministry of Early Childhood Education in South Korea. In the field test, 50 children aged five–seven years participated to experience the activity services at home for 4 days. After completing the 4 days of field testing, we conducted customer satisfaction (CSAT) surveys, Godspeed evaluations and interviews to quantitatively and qualitatively verify the evaluations by the children and parents. As a result, 92% of the children and 80% of the parents evaluated that they were satisfied with the service. In addition, our results revealed that the social robot-based service contributed to improving the relationship between children and families by functioning as a messenger. Finally, the lessons learned from the service development and field tests were discussed to aid service designers and robotics engineers.
Are we joining the One Health dots? A scoping review of research on the one health effects of extreme weather events in eastern Australia
Authors: Ward Rebecca , Brookes Victoria J. , Rahman Kazi Mizanur
Published: July 2024

Extreme weather events such as floods, bushfires, cyclones, and drought, are projected to increase in eastern Australia. Understanding how these events influence the combined, sustainable well-being of humans, animals, and ecosystems – that is One Health – will enable development of transdisciplinary and ultimately more effective interventions. A scoping review was conducted to explore the research associated with the effects of extreme weather events in eastern Australia using a One Health lens, specifically identifying the type of extreme weather events studied, the research conducted in the context of One Health, and gaps to inform improved One Health implementation. The review followed JBI guidelines (based on PRISMA). Eligible research was peer-reviewed, in English, and published since 2007, in which primary research studies investigated the impact of extreme weather events in eastern Australia on at least two of ecosystems, human health, and animal health. Using structured search terms, six databases were searched. Following removal of duplicates, 870 records were screened by two reviewers. Eleven records were eligible for data extraction and charting. The scope of extreme weather events studied was relatively limited, with studies in flood and bushfire settings predominating, but relatively little research on cyclones. Major health themes included more than the impact of extreme weather events on physical health (zoonotic and vector-borne diseases) through investigation of social well-being and mental health in the context of the human-animal bond in evacuation behaviors and drought. Research gaps include studies across a broader range of extreme weather events and health topics, as well as a more comprehensive approach to including the impacts of extreme weather events on all three domains of One Health. The limited research focus inevitably translates to limited recommendations for policy, planning and response to manage extreme weather event emergencies. Given the expected increase in frequency of these events, there is a critical need for more comprehensive primary research to better identify strategies and facilitate implementation of One Health promotion for improved outcomes in extreme weather event emergencies.
Analiza obecności języka polskiego w krajobrazie językowym londyńskiej dzielnicy
Authors: Romanowski Piotr
Published: July 2024

The article describes the Polish language in the public space of the London district of Ealing, known as the location of the Polish diaspora. The study presents the status of the Polish language, the issue of the dominance of English over the Polish language, and attempts to answer the question of how these languages combine in bi-/multilingual signage. A methodological framework was adopted to analyse the corpus of signs, covering aspects of semiotic and linguistic analysis, such as context, domain, language dominance, genre, and text function. The Polish language indexes and constructs public spaces in various areas of Ealing as places of identity, and Poles thus contribute through their actions to a high degree of ethnolinguistic vitality of the language.
Język młodzieży – perspektywa glottodydaktyczna
Authors: Maciołek Marcin , Smereczniak Małgorzata
Published: July 2024

As stated in the title, the article is devoted to the sociolect of youth, examined in the context of teaching Polish as a foreign, second, and heritage language. In response to the rapidly increasing number of foreign students in Poland’s schools and universiƟties, the authors investigated to what extent the indicated variety of Polish language is present in course books intended for this group of learners. The authors discuss the signifcant features of youth language with references to current research findings. They stress the challenges involved in incorporating such content into glottodidactic practice. Nevertheless, they deem it necessary due to the socialising function of youth slang and its significance in shaping young people’s identities.
Polskojęzyczne zbiory rękopiśmienne z XVII i XVIII w. w zagranicznych bibliotekach i archiwach. Sprawozdanie z kwerendy
Authors: Rodek Ewa
Published: July 2024

The paper presents the results of a query concerning Polish-language manuscripts from the 17th and 18th centuries in four centres outside o f Poland, i.e. the Polish Library in Paris, Riksarkivet in Stockholm, the Vilnius University Library, and the Library of the Lithuanian Academy of Sciences. The documents collected during the search differ with respect to their genre, as well as time and place of origin, making them a valuable addition to the planned electronic corpus of manuscripts from that period. The article discusses the types of texts in each of the collections and provides search guidelines aimed at helping the reader design their own research and collect data.
Automatic Quality Assessment of Pork Belly via Deep Learning and Ultrasound Imaging
Authors: Wang Tianshuo , Yang Huan , Zhang Chunlei , Chao Xiaohuan , Liu Mingzheng , Chen Jiahao , Liu Shuhan , Zhou Bo
Published: July 2024

Pork belly, prized for its unique flavor and texture, is often overlooked in breeding programs that prioritize lean meat production. The quality of pork belly is determined by the number and distribution of muscle and fat layers. This study aimed to assess the number of pork belly layers using deep learning techniques. Initially, semantic segmentation was considered, but the intersection over union (IoU) scores for the segmented parts were below 70%, which is insufficient for practical application. Consequently, the focus shifted to image classification methods. Based on the number of fat and muscle layers, a dataset was categorized into three groups: three layers (n = 1811), five layers (n = 1294), and seven layers (n = 879). Drawing upon established model architectures, the initial model was refined for the task of learning and predicting layer traits from B-ultrasound images of pork belly. After a thorough evaluation of various performance metrics, the ResNet18 model emerged as the most effective, achieving a remarkable training set accuracy of 99.99% and a validation set accuracy of 96.22%, with corresponding loss values of 0.1478 and 0.1976. The robustness of the model was confirmed through three interpretable analysis methods, including grad-CAM, ensuring its reliability. Furthermore, the model was successfully deployed in a local setting to process B-ultrasound video frames in real time, consistently identifying the pork belly layer count with a confidence level exceeding 70%. By employing a scoring system with 100 points as the threshold, the number of pork belly layers in vivo was categorized into superior and inferior grades. This innovative system offers immediate decision-making support for breeding determinations and presents a highly efficient and precise method for assessment of pork belly layers.
Efficiently Substituting Dietary Fish Meal with Terrestrial Compound Protein Enhances Growth, Health, and Protein Synthesis in Largemouth Bass
Authors: Chen Fang , Ding Zhirong , Su Zeliang , Guan Junfeng , Xu Chao , Wang Shuqi , Li Yuanyou , Xie Dizhi
Published: July 2024

Inappropriate substitution of dietary fishmeal (FM) can adversely affect the growth, health, and metabolism of carnivorous fish species. To effectively reduce the amount of dietary FM in carnivorous largemouth bass (Micropterus salmoides), a terrestrial compound protein (Cpro) with chicken meal, bone meal, and black soldier fly protein was used to formulate four isoproteic (52%) and isolipidic (12%) diets, namely T1 (36% FM), T2 (30% FM), T3 (24% FM), and T4 (18% FM), for feeding juveniles (initial weight: ~12 g) for 81 days. Results indicated that the growth performance, feed efficiency, and morphological indicators, as well as muscle texture and edible quality of fish, did not differ significantly among the four groups. However, the muscle protein contents and ATP/AMP ratio of fish in the T4 group were significantly increased in comparison with those of fish in the T1 group, while the opposite was true for muscle glycogen. Compared with the T1 group, high serum total amino acid and MDA contents, as well as low AST activities, were observed in the T3 and T4 groups, and relatively high intestinal trypsin and lipase activities were found in the T2–T4 groups. The transcripts of intestinal proinflammatory cytokines (il-1β, il-6, and tnf-α) were downregulated in the T2–T4 groups compared with T1 group, while the expression of anti-inflammatory cytokines (il-10) and tight junction (zo-1 and occludin) showed the reverse trend. The mRNA expression of positive regulators related to protein synthesis (sirt1, pgc1-α, pi3k, and akt) were significantly upregulated in the muscle of fish fed diets T3 and T4, while their negative regulators (4e-bp1) mRNA levels were downregulated. The results indicate that the dietary FM of largemouth bass could be effectively reduced to at least 18% by the Cpro, which is beneficial to health, digestion, and protein synthesis for maintaining accelerated growth.
Vitamin Solutions Effects on Reproduction of Broodstock, Growth Performance, and Survival Rate of Pangasius Catfish Fingerlings
Authors: Da Chau Thi , Xuyen Bui Thi Kim , Nguyen Thi Kieu Oanh , Tang Van Tai , Ha Pham Thi Thu , Pham Minh Tan , Berg Håkan
Published: July 2024

This study evaluates the effect of different diets supplemented with vitamin solutions on Pangasius catfish broodstock reproduction, growth performances, and the survival rates of fish larvae and fingerling. The growth and reproductive performances of breeders fed with different test diets showed significant differences among the six tested diets (p < 0.05). The highest final body weight (FBW), weight gain (WG), daily weight gain (DWG), specific growth rate (SGR) of broodstock, and survival rate of Pangasius fingerlings were found in Treatment 5, which contained 0.6% H-OVN mixed with 12.6% algal oil, and Treatment 3, which contained 0.6% vitamin premix H-OVN. The average gonadosomatic index (GSI), relative fecundity index (RFI), fertilized eggs, hatching rates of eggs, and survival rate of fingerlings was 9.1 ± 2.8 (6.7–12.8%), 133,224 ± 39,090 (104,267–199,512 eggs/kg), 77.9 ± 22.2 (62.2–93.6%), and 45.3 ± 17.4 (22.0–66.3%), respectively. The findings of this study showed that the diet containing 35% CP contents supplemented with 0.6% vitamin premix H-OVN mixed with algal oils showed the highest results in terms of growth, reproductive performance indices, and survival rates of Pangasius catfish fingerlings.
Gender Recognition Based on the Stacking of Different Acoustic Features
Authors: Yücesoy Ergün
Published: July 2024

A speech signal can provide various information about a speaker, such as their gender, age, accent, and emotional state. The gender of the speaker is the most salient piece of information contained in the speech signal and is directly or indirectly used in many applications. In this study, a new approach is proposed for recognizing the gender of the speaker based on the use of hybrid features created by stacking different types of features. For this purpose, four different features, namely Mel frequency cepstral coefficients (MFCC), Mel scaled power spectrogram (Mel Spectrogram), Chroma, Spectral contrast (Contrast), and Tonal Centroid (Tonnetz), and twelve hybrid features created by stacking these features were used. These features were applied to four different classifiers, two of which were based on traditional machine learning (KNN and LDA) while two were based on the deep learning approach (CNN and MLP), and the performance of each was evaluated separately. In the experiments conducted on the Turkish subset of the Common Voice dataset, it was observed that hybrid features, created by stacking different acoustic features, led to improvements in gender recognition accuracy ranging from 0.3 to 1.73%.
High-Intensity Laser Therapy in Pain Management of Knee Osteoarthritis
Authors: Poenaru Daniela , Sandulescu Miruna Ioana , Potcovaru Claudia Gabriela , Cinteza Delia
Published: July 2024

Knee osteoarthritis (KO) is an important health condition, affecting one third of people aged 65 years or more. Pain is the main cause of disability. Pain management in KO includes pharmacological and non-pharmacological modalities. Patient education, lifestyle changes, physical exercise, and physical agents are prescribed as a first approach for pain control. Laser therapy is part of many therapeutical protocols, with two forms: low-level laser therapy (LLLT) and high-intensity laser therapy (HILT). This paper aimed to stress the advantages of HILT based on a greater wavelength, higher energy delivery, and deeper tissue penetration. Research on 23 published trials revealed that the analgesic effect is rapid, cumulative, and long lasting. Compared to sham, to LLLT, or to other combinations of therapeutical modalities, HILT provided significantly better results on pain reduction and functional improvement. Ultrasound examination showed a reduction in intra-articular inflammation.
The Abundance of FOXP3, FOXP3/CD4 and CD8 Cells in the Microenvironment of Nodular Sclerosis and Mixed Cellularity Subtypes Is Associated with the Epstein–Barr Virus Status of Classic Hodgkin Lymphoma
Authors: Pavlović Antonia , Miljak Antonija , Brzica Katarina , Glavina Durdov Merica
Published: July 2024

Thymic regulatory lymphocytes (Tregs) are rare in the normal periphery where they mediate immune tolerance but accumulate in the tumor immune microenvironment (TIM), reducing the antitumor response. Subtypes of classical Hodgkin lymphoma (CHL) are characterized by a minority of malignant Hodgkin and Reed–Sternberg cells (HRS) and an abundant TIM that plays a key role in modulating the disease. CHL is related to the Epstein–Barr virus (EBV), whose oncogenes influence the growth of HRS. We analyzed the number of T lymphocytes expressing the regulatory marker FOXP3 in CHL with regard to EBV status. The tumor tissue of 182 patients was stained by double immunohistochemistry for FOXP3, CD4, and CD8, and the number of different phenotypes was analyzed microscopically. EBV status was determined by EBER in situ hybridization. EBV-positive CHL was confirmed in 28% of patients and was associated with mixed cellularity (MC) (p < 0.001), older age (p < 0.001), and unfavorable outcomes (p = 0.038). The number of CD8+ T lymphocytes differed according to the EBV status of MC and nodular sclerosis (NS), and was the lowest in EBV-negative NS (p = 0.001). Likewise, the numbers for FOXP3 and FOXP3/CD4 were different, and were the lowest in EBV-negative MC (p = 0.035 and p = 0.041, respectively). Values above a median of FOXP3 and CD4 are associated with longer progression-free survival (p = 0.039 and p < 0.001, respectively). EBV impacts the composition of T cell phenotypes in TIM, among which the amount of CD4 and FOXP3 is prognostically valuable.
Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients
Authors: Schmidtner Niklas , Utrata Alexander , Mester Patricia , Schmid Stephan , Müller Martina , Pavel Vlad , Buechler Christa
Published: July 2024

Infectious diseases are associated with low iron levels and the induction of hepcidin, the primary protein regulating cellular iron export. Bone morphogenetic protein 6 (BMP6), a key regulator of hepcidin expression, has not yet been analyzed in the plasma of patients with systemic inflammatory response syndrome (SIRS) or sepsis. An analysis of 38 SIRS, 39 sepsis, and 78 septic shock patients revealed similar levels of BMP6 in sepsis and septic shock, which were lower compared to patients with SIRS and healthy controls. Plasma BMP6 levels did not correlate with procalcitonin and C-reactive protein levels in patients with SIRS or sepsis/septic shock. Neither bacterial nor SARS-CoV-2 infections affected plasma BMP6 levels. There was no difference in BMP6 levels between ventilated and non-ventilated patients, or between patients with and without dialysis. Vasopressor therapy did not alter BMP6 levels. Survivors had plasma BMP6 levels similar to non-survivors. Due to the high variability of plasma BMP6 levels, these analyses have limited clinical relevance. Iron, ferritin, and transferrin levels were known in at least 50% of patients but did not correlate with plasma BMP6 levels. In conclusion, this study showed normal BMP6 plasma levels in SIRS, which are reduced in patients with sepsis and septic shock. This suggests that the commonly observed increase in hepcidin levels and the decline in iron levels in SIRS, sepsis, and septic shock are not due to higher BMP6.
Electrotactile BCI for Top-Down Somatosensory Training: Clinical Feasibility Trial of Online BCI Control in Subacute Stroke Patients
Authors: Savić Andrej M. , Novičić Marija , Miler-Jerković Vera , Djordjević Olivera , Konstantinović Ljubica
Published: July 2024

This study investigates the feasibility of a novel brain–computer interface (BCI) device designed for sensory training following stroke. The BCI system administers electrotactile stimuli to the user’s forearm, mirroring classical sensory training interventions. Concurrently, selective attention tasks are employed to modulate electrophysiological brain responses (somatosensory event-related potentials—sERPs), reflecting cortical excitability in related sensorimotor areas. The BCI identifies attention-induced changes in the brain’s reactions to stimulation in an online manner. The study protocol assesses the feasibility of online binary classification of selective attention focus in ten subacute stroke patients. Each experimental session includes a BCI training phase for data collection and classifier training, followed by a BCI test phase to evaluate online classification of selective tactile attention based on sERP. During online classification tests, patients complete 20 repetitions of selective attention tasks with feedback on attention focus recognition. Using a single electroencephalographic channel, attention classification accuracy ranges from 70% to 100% across all patients. The significance of this novel BCI paradigm lies in its ability to quantitatively measure selective tactile attention resources throughout the therapy session, introducing a top-down approach to classical sensory training interventions based on repeated neuromuscular electrical stimulation.
IFNγ-Induced Bcl3, PD-L1 and IL-8 Signaling in Ovarian Cancer: Mechanisms and Clinical Significance
Authors: Reddy Suprataptha U. , Sadia Fatema Zohra , Vancura Ales , Vancurova Ivana
Published: July 2024

IFNγ, a pleiotropic cytokine produced not only by activated lymphocytes but also in response to cancer immunotherapies, has both antitumor and tumor-promoting functions. In ovarian cancer (OC) cells, the tumor-promoting functions of IFNγ are mediated by IFNγ-induced expression of Bcl3, PD-L1 and IL-8/CXCL8, which have long been known to have critical cellular functions as a proto-oncogene, an immune checkpoint ligand and a chemoattractant, respectively. However, overwhelming evidence has demonstrated that these three genes have tumor-promoting roles far beyond their originally identified functions. These tumor-promoting mechanisms include increased cancer cell proliferation, invasion, angiogenesis, metastasis, resistance to chemotherapy and immune escape. Recent studies have shown that IFNγ-induced Bcl3, PD-L1 and IL-8 expression is regulated by the same JAK1/STAT1 signaling pathway: IFNγ induces the expression of Bcl3, which then promotes the expression of PD-L1 and IL-8 in OC cells, resulting in their increased proliferation and migration. In this review, we summarize the recent findings on how IFNγ affects the tumor microenvironment and promotes tumor progression, with a special focus on ovarian cancer and on Bcl3, PD-L1 and IL-8/CXCL8 signaling. We also discuss promising novel combinatorial strategies in clinical trials targeting Bcl3, PD-L1 and IL-8 to increase the effectiveness of cancer immunotherapies.
Understanding the Role of Toll-Like Receptors 9 in Breast Cancer
Authors: Al-alem Umaima , Al-Saruri Alaa , Bamahros Hasan , Mahmoud Abeer M. , Sible Emily , Hasan Uzma A.
Published: July 2024

Breast cancer is a significant global issue, ranking as the second most common cancer among women worldwide and a leading cause of cancer-related deaths. Although the exact causes of this increase remain unclear, factors such as genetics, epigenetics, obesity, sedentary lifestyle, tobacco use, and vitamin D deficiency have been implicated. The Toll-like receptor 9 (TLR9) is recognized for its role in inflammation and innate immunity; however, its specific involvement in breast cancer pathogenesis requires further investigation. This study aims to systematically review the existing literature on TLR9 expression in normal and cancerous breast tissue, providing current knowledge and identifying gaps. Relevant articles in English were from PubMed, Scopus, and Google Scholar, with the inclusion criteria focusing on studies evaluating TLR9 mRNA and protein expression. The review found that TLR9 mRNA and protein exhibit variable expressions in both normal and cancerous breast tissue, highlighting the need for further research to clarify TLR9’s role in breast cancer.
Lung Cancer Screening—Trends and Current Studies
Authors: Czerw Aleksandra , Deptała Andrzej , Partyka Olga , Pajewska Monika , Wiśniewska Ewa , Sygit Katarzyna , Wysocki Sławomir , Cipora Elżbieta , Konieczny Magdalena , Banaś Tomasz , Małecki Krzysztof , Grochans Elżbieta , Grochans Szymon , Cybulska Anna M. , Schneider-Matyka Daria , Bandurska Ewa , Ciećko Weronika , Drobnik Jarosław , Pobrotyn Piotr , Grata-Borkowska Urszula , Furtak-Pobrotyn Joanna , Sierocka Aleksandra , Marczak Michał , Kozlowski Remigiusz
Published: July 2024

Lung cancer is the leading cause of death among all the oncological diseases worldwide. This applies to both women and men; however, the incidence and mortality among women is on the rise. In 2020, lung cancer was responsible for 1.8 million deaths (18%). More than 90% of lung cancer cases and 77.1% of lung cancer deaths occur in countries with high and very high HDI (human development index) values. The aim of our study is to the present trends and most recent studies aimed at lung cancer screening. In the face of the persistently high mortality rate, conducting research aimed at extending already-implemented diagnostic algorithms and behavioural interventions focused on smoking cessation is recommended.
Detection of Carcinoma-Associated Fibroblasts Derived from Mesothelial Cells via Mesothelial-to-Mesenchymal Transition in Primary Ovarian Carcinomas
Authors: Tomero-Sanz Henar , Jiménez-Heffernan José Antonio , Fernández-Chacón María Concepción , Cristóbal-García Ignacio , Sainz de la Cuesta Ricardo , González-Cortijo Lucía , López-Cabrera Manuel , Sandoval Pilar
Published: July 2024

Carcinoma-associated fibroblasts (CAFs) are highly accumulated in the tumor-surrounding stroma of primary epithelial ovarian cancer (OC). CAFs exert important functions for the vascularization, growth, and progression of OC cells. However, the origin of CAFs in primary OC had not yet been studied, and they were assumed to arise from the activation of resident fibroblasts. Here, we compared CAFs in the ovary to CAFs found in peritoneal metastases from patients with advanced OC. Our findings show that CAFs from primary tumors and peritoneal metastases share the expression of mesothelial markers. Therefore, similar to peritoneal carcinomatosis, CAFs in primary ovarian carcinomas may originate from mesothelial cells via a mesothelial-to-mesenchymal transition. The detection of mesothelial-derived CAFs in tumors confined to the ovary and identification of biomarkers could be the key to the early detection of OC and peritoneal spread.
Long-Term Oncologic Outcomes of Omitting Axillary Surgery in Breast Cancer Patients with Chest Wall Recurrence after Mastectomy
Authors: Lim Geok Hoon , Alcantara Veronica Siton , Allen John Carson , Saffari Seyed Ehsan , Tan Veronique Kiak Mien , Tan Kiat Tee Benita , Ngaserin Sabrina , Tan Su Ming , Leong Lester Chee Hao , Wong Fuh Yong
Published: July 2024

Background: The management of the axilla in breast cancer patients with isolated chest wall recurrence (CWR) after mastectomy remains controversial. Although sentinel lymph node biopsy (SLNB) for restaging is feasible, its role is unclear. We aimed to determine if the omission of axillary restaging surgery in female patients with operable presumably isolated CWRs could result in an increased risk of second recurrences. Methods: In this retrospective multicentre study, patients who developed CWRs were reviewed. We excluded patients with suspected or concomitant regional/distant metastases, bilateral cancers and patients without CWR surgery. Patients’ demographics, pathological data and subsequent recurrences were collected from a prospective database and were compared between patients with axillary lymph node dissection (ALND) and/or SLNB versus no axillary operation at CWR. Findings: A total of 194 patients with CWRs were eligible. The median age at CWR was 56.0 (IQR 47.0–67.0) years old. At recurrence, 8 (4.1%), 5 (2.6%) and 181 (93.3%) patients had ALND, SLNB and no axillary operation, respectively. Patients with no axillary surgery during CWR were associated with, at primary cancer, a lower incidence of ductal carcinoma in situ as diagnosis (p = 0.007) and older age (p = 0.022). Subsequent ipsilateral axillary (p = 0.768) and second recurrences (p = 0.061) were not statistically different between patients with and without axillary surgery at CWR on median follow-up of 59.5 (IQR 27.3–105) months. Interpretation: In patients without evidence of concomitant regional or distant metastasis at CWR diagnosis, omission of axillary restaging surgery was not associated with an increased ipsilateral axillary or second recurrences on long-term follow-up.
A Survey on Artificial-Intelligence-Based Internet of Vehicles Utilizing Unmanned Aerial Vehicles
Authors: Ali Shah Syed Ammad , Fernando Xavier , Kashef Rasha
Published: July 2024

As Autonomous Vehicles continue to advance and Intelligent Transportation Systems are implemented globally, vehicular ad hoc networks (VANETs) are increasingly becoming a part of the Internet, creating the Internet of Vehicles (IoV). In an IoV framework, vehicles communicate with each other, roadside units (RSUs), and the surrounding infrastructure, leveraging edge, fog, and cloud computing for diverse tasks. These networks must support dynamic vehicular mobility and meet strict Quality of Service (QoS) requirements, such as ultra-low latency and high throughput. Terrestrial wireless networks often fail to satisfy these needs, which has led to the integration of Unmanned Aerial Vehicles (UAVs) into IoV systems. UAV transceivers provide superior line-of-sight (LOS) connections with vehicles, offering better connectivity than ground-based RSUs and serving as mobile RSUs (mRSUs). UAVs improve IoV performance in several ways, but traditional optimization methods are inadequate for dynamic vehicular environments. As a result, recent studies have been incorporating Artificial Intelligence (AI) and Machine Learning (ML) algorithms into UAV-assisted IoV systems to enhance network performance, particularly in complex areas like resource allocation, routing, and mobility management. This survey paper reviews the latest AI/ML research in UAV-IoV networks, with a focus on resource and trajectory management and routing. It analyzes different AI techniques, their training features, and architectures from various studies; addresses the limitations of AI methods, including the demand for computational resources, availability of real-world data, and the complexity of AI models in UAV-IoV contexts; and considers future research directions in UAV-IoV.
Non-Coding RNAs Extended Omnigenic Module of Cancers
Authors: Li Jie , Wang Bingbo , Ma Xiujuan
Published: July 2024

The emergence of cancers involves numerous coding and non-coding genes. Understanding the contribution of non-coding RNAs (ncRNAs) to the cancer neighborhood is crucial for interpreting the interaction between molecular markers of cancer. However, there is a lack of systematic studies on the involvement of ncRNAs in the cancer neighborhood. In this paper, we construct an interaction network which encompasses multiple genes. We focus on the fundamental topological indicator, namely connectivity, and evaluate its performance when applied to cancer-affected genes using statistical indices. Our findings reveal that ncRNAs significantly enhance the connectivity of affected genes and mediate the inclusion of more genes in the cancer module. To further explore the role of ncRNAs in the network, we propose a connectivity-based method which leverages the bridging function of ncRNAs across cancer-affected genes and reveals the non-coding RNAs extended omnigenic module (NeOModule). Topologically, this module promotes the formation of cancer patterns involving ncRNAs. Biologically, it is enriched with cancer pathways and treatment targets, providing valuable insights into disease relationships.
A New Semi-Quantum Two-Way Authentication Protocol between Control Centers and Neighborhood Gateways in Smart Grids
Authors: Zhang Qiandong , Zhang Kejia , Hou Kunchi , Zhang Long
Published: July 2024

To address the potential threat to the power grid industry posed by quantum computers and ensure the security of bidirectional communication in smart grids, it is imperative to develop quantum-safe authentication protocols. This paper proposes a semi-quantum bidirectional authentication protocol between a control center (CC) and a neighboring gateway (NG). This method uses single photons to facilitate communication between the CC and the NG. Security analysis demonstrates that the protocol can effectively resist common attack methods, including double CNOT attacks, impersonation attacks, interception-measurement-retransmission attacks, and entanglement-measurement attacks. Comparisons with other protocols reveal that this protocol has significant advantages, making it more appealing and practical for real-world applications. Finally, by simulating the protocol on the IBM quantum simulator, this protocol not only validates the theoretical framework but also confirms the practical feasibility of the protocol.
Solar Energy Received on Flat-Plate Collectors Fixed on 2-Axis Trackers: Effect of Ground Albedo and Clouds
Authors: Kambezidis Harry D. , Kavadias Kosmas A. , Farahat Ashraf M.
Published: July 2024

This study investigates the performance of isotropic and anisotropic diffuse models to estimate the total solar energy received on flat-plate collectors fixed on dual-axis trackers. These estimations are applied at twelve sites selected in both hemispheres with different terrain and environmental conditions. The diffuse (or transposition) models used in this study are the isotropic Liu-Jordan (L&J), Koronakis (KOR), Badescu (BAD), and Tian (TIA), and the anisotropic Hay (HAY), Reindl (REI), Klucher (KLU), Skartveit and Olseth (S&O), and Steven and Unsworth (S&U). These models were chosen because of their simplicity in the calculations and minimum number of input values. The results show that a single transposition model is not efficient for all sites; therefore, the most appropriate models are selected for each site under all, clear, intermediate, and overcast conditions in skies. On the other hand, an increase in the ground albedo in the vicinity of the solar installation can increase the annual inclined solar availability on a two-axis tracker by at least 9% on average. Further, a linear dependence of the annual inclined solar energy on the variation of the ground albedo was found. Also, a linear relationship exists between the annual diffuse-fraction and cloud-modification factor values at the 12 sites.
Insights into the Co-Exploration Potential of Gas in the Shale and Tight Sandstone of the Lower Silurian Formation in the Gongtan Syncline Area in Southeastern Sichuan Basin, SW China
Authors: Wang Shengxiu , Zhang Ye , Wang Wei , Yang Yang , Wang Qiaoli , Yu Chuan , Zhao Difei , Zeng Chunlin , Xu Yao
Published: July 2024

This work aims to explore the Lower Silurian shale gas and tight sandstone gas accumulation conditions in the Gongtan Syncline, southeastern Sichuan Basin. The sedimentary environment, organic geochemical characteristics, reservoir characteristics, gas content, and preservation conditions of the reservoir were comprehensively analyzed. The results show that the Wufeng–Longmaxi Formation shale formed in a deep-water shelf characterized by a large thickness (50–70 m), appropriate total organic carbon content (0.5–5.47%), high maturity (2.38%), high brittle mineral content (67.10%), and large gas content (0.71–1.64 m3/t), and the formations show the good resource potential of the shale gas. The Xintan Formation formed in a lower shore phase, and the tight sandstone is locally developed with a small thickness. The Xiaoheba Formation formed in an upper-middle shore phase, and the tight sandstone is stably distributed with large thicknesses. The porosity and permeability of the two sets of sandstone are small and some natural fractures are developed in the sandstone, but the fracture filling degree is higher. The results of well logging show that there are abnormally high values of total hydrocarbon in both the Xintan Formation and Xiaoheba Formation; this indicates that tight sandstone gas is developed in the Lower Silurian strata. A comprehensive study indicates that the Lower Silurian of the Gongtan Syncline has the geological conditions for the formation of shale gas and tight sandstone gas, which are the “Two gases” with good co-exploration prospects.
In-Depth Analysis of the Burst of a Liquefied Petroleum Gas Tank in Gravedona, Italy
Authors: Lomazzi Luca , Passoni Stefano , Mereu Riccardo , Cadini Francesco , Giglio Marco
Published: July 2024

This work presents a comprehensive study of the burst of an LPG tank in Gravedona, Italy. The possible causes of the burst were investigated through analytical methods and numerical simulations. That is, an analytical lumped system analysis was conducted to accurately predict the thermodynamic properties of the LPG–air mixture within the tank during filling operations. Additionally, computational fluid dynamics (CFD) simulations were carried out to (i) better capture local effects and (ii) determine if the mixture reached explosive conditions during these operations. The likelihood that possible mechanical defects led to the burst of the tank during filling operations was also evaluated through numerical simulations. The proposed methods were validated against experimental observations, confirming their accuracy and reliability. Furthermore, a specifically developed analytical model was used to describe the tank’s dynamic response after the burst. The results provided a comprehensive understanding of the cause of the burst thanks to the combination of analytical models and numerical simulations. The derived insights not only pinpointed the factors leading to the incident, but also provided valuable perspectives for predicting and preventing similar occurrences.
Impact of Renewable and Non-Renewable Energy Consumption on the Production of the Agricultural Sector in the European Union
Authors: Suproń Błażej , Myszczyszyn Janusz
Published: July 2024

The primary objective of this study is to examine the relationships between energy consumption in agriculture from renewable and non-renewable sources and the production levels in the agricultural sector across European Union countries. Additionally, this study aims to identify countries that differ in the development of their agricultural sector in terms of environmental care and to highlight the causes and consequences of these identified disparities. The classification of countries was conducted using the Principal Component Analysis method and a biplot. Panel data for the period 2000–2022, a VAR model, the impulse response function (IRF), and causality tests were used for this study. The results indicate two distinct groups of countries that significantly differ in adopting green agricultural practices. Only seven EU countries stand out for sustainable agriculture with low pesticide use, a significant share of organic farms, and high use of renewable energy in agriculture. Energy consumption affects agricultural production differently in the two groups of countries studied: in countries with sustainable agriculture, an increase in renewable energy consumption translates into a positive increase in agricultural production. On the other hand, an increase in non-renewable energy consumption shows a dampening effect on agricultural production growth, especially in countries with less sustainable agriculture. The results of this study highlight the need to promote renewable energy development in agriculture and raise awareness about the adverse environmental effects of intensive agriculture while emphasising the positive impact of organic agriculture on agricultural production.
Multiomics Screening Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits
Authors: Nikpay Majid
Published: July 2024

An understanding of the molecular mechanism whereby an environmental chemical causes a disease is important for the purposes of future applications. In this study, a multiomics workflow was designed to combine several publicly available datasets in order to identify CpG sites and genes that mediate the impact of exposure to environmental chemicals on cardiometabolic traits. Organophosphate and prenatal lead exposure were previously reported to change methylation level at the cg23627948 site. The outcome of the analyses conducted in this study revealed that, as the cg23627948 site becomes methylated, the expression of the GNA12 gene decreases, which leads to a higher body fat percentage. Prenatal perfluorooctane sulfonate exposure was reported to increase the methylation level at the cg21153102 site. Findings of this study revealed that higher methylation at this site contributes to higher diastolic blood pressure by changing the expression of CHP1 and GCHFR genes. Moreover, HKR1 mediates the impact of B12 supplementation → cg05280698 hypermethylation on higher kidney function, while CTDNEP1 mediates the impact of air pollution → cg03186999 hypomethylation on higher systolic blood pressure. This study investigates CpG sites and genes that mediate the impact of environmental chemicals on cardiometabolic traits. Furthermore, the multiomics approach described in this study provides a convenient workflow with which to investigate the impact of an environmental factor on the body’s biomarkers, and, consequently, on health conditions, using publicly available data.