bluuebunny/crossref_metadata_2025 huggingface dataset:
Potencial antidiabético de extractos de Cylindropuntia imbricata (Haw.) F. M. Knuth, Opuntia engelmannii Salm-Dyck ex Engelm., Ibervillea sonorae (S. Wats.) Greene y Theobroma cacao L.
Authors: De la Sota-Esparza Gastaldo Emmanuel , Alvarado-Vázquez Marco Antonio , Rivas-Morales Catalina , Rocha-Estrada Alejandra , Chávez-Reyes Arturo , Ortíz-Martínez David Mizael
Published: August 2024

La diabetes mellitus es una enfermedad que no decrece y afecta a más de 537 millones de personas en el mundo. La diabetes al complicarse daña varios órganos hasta causar la muerte. Los fármacos en uso para contrarrestar la enfermedad producen efectos secundarios; circunstancia que ha propiciado la investigación en plantas con propiedades antidiabéticas. El objetivo de este estudio fue evaluar el potencial antidiabético de los extractos obtenidos por maceración de las siguientes partes de la planta: del cladodio y semilla de Cylindropuntia imbricata (Cactaceae), del cladodio y semilla de Opuntia engelmannii (Cactaceae), de la raíz de Ibervillea sonorae (Cucurbitaceae) y de la semilla de Theobroma cacao (Malvaceae) mezcladas con solventes de diferente polaridad (hexano, acetato de etilo, diclorometano y metanol). Se obtuvieron un total de 24 extractos sometidos a los análisis: 1) de cribado fitoquímico para determinar su composición, 2) de toxicidad en células B16F10 mediante la prueba de azul alamar, 3) decapacidad antioxidante a través de la inhibición de DPPH, y 4) de evaluación in vitro para conocer su capacidad antihiperglucémica (inhibición de la alfa glucosidasa). Los resultados obtenidos, de los extractos metanólicos con las semillas de O. engelmannii y T. cacao, así como los de acetato de etilo con las semillas de T. cacao y C. imbricata mostraron una actividad antioxidante y antihiperglucémica. Sin toxicidad en las células B16F10, y con potencial antidiabético in vitro.
Reseña del Evento: 2 do foro de Transición Energética Sostenible, Santa Cruz, Argentina
Authors: Herrera Mabel
Published: August 2024

Santa Cruz Produce
Metaphors of communication professionals in higher education: between the trivial and significant
Authors: Sataøen Hogne Lerøy , Lövgren Daniel , Neby Simon
Published: August 2024

This study explores the evolving, however also “messy”, role of communication professionals in higher education institutions (HEIs), who are involved in organizational science communication. Despite substantial growth and professionalization within HEIs' communication departments, limited research delves into these professionals' own perspectives and their self-understanding. Our investigation employs a metaphors-in-use perspective, through 26 interviews in ten Scandinavian HEIs. The paper contributes to the research on organizational science communication by unraveling the metaphors used by communication professionals: the salesman, the marketplace-facilitator, the police, the missionary, the storyteller, and the overhead-cost, gaining an understanding of how communication professionals perceive their own role.
Civillikuma 51. pants kā lakmusa papīrs esošam tiesiskam regulējumam
Authors:   Latvijas Universitāte, Balodis Ringolds
Published: August 2024

Although the Church in Latvia is separated from the state, there are eight denominations which are permitted by the state to conduct marriage registration. On behalf of the state, with legal force, but according to the procedure adopted in the denomination. The Civil Code of Latvia names these denominations: Roman Catholics, Evangelical Lutherans, Orthodox, Old Believers, Methodists, Baptists, Seventh-Day Adventists and Jews. Special laws have been adopted for all the aforementioned denominations, which stipulate their special status, including the right to register marriages on behalf of the state. In 2023, the Latvian Parliament decided that Latvian neo-pagans “Dievturi” will join the above group of denominations – godmen who are closely related to the cultivation of national traditions. The “Dievturi” have been fighting for this opportunity for more than twenty years. Initially, the deputies were only inclined to supplement Article 51 of the Civil Code with the ninth denomination and only after a long debate realized that such a step would not be legally correct. It will be a circumvention and disparagement of special Church laws. It would also incur significant damage to the legal framework established for religious organizations that has developed over decades. As a result, the parliament decided to supplement the Civil Code with the denomination “Dievturi”, although noting that “The amendment in the article regarding the right to conclude a marriage also with a clergyman of the theocratic denomination, who has permission from the head of the denomination, enters into force at the same time as a separate law on the regulation of mutual relations between the state and the religious organization of “Dievturi” and will be included in the wording of the law on the date of entry into force of the separate law.” In the article, the author provides substantiation to the position that the Civil Code should abandon the list of denominations, instead providing a reference to the special laws of the Church. Such an approach would be clearer legally and would free the legislator from adopting legal norms that create questions and unnecessary risks for those applying the law.
Tiesas kontroles pār valsts pārvaldi organizēšanas modeļi
Authors:   Latvijas Universitāte, Kovaļevska Anita
Published: August 2024

The aim of the article is to provide an overview comprising the organisation models of judicial review, using professor Mariolina Eliantonio’s classification, as well as to analyse the Latvian model according to this classification. The author concludes that there is a mixed model in Latvia regarding the separation of general courts and administrative courts. There are no specialized administrative courts in Latvia, and there are usually three levels of courts for administrative cases. Latvia has a mixed model of intra-administrative objection procedure: partially mandatory and partially voluntary. Here, the law exhaustively lists the forms of public authority’s acts and actions that can be appealed at the administrative court.
Notiesājoša sprieduma taisīšanas iespējamība rakstveida procesā
Authors:   Latvijas Universitāte, Kulmanis Oskars
Published: August 2024

The possibility and necessity of using the written procedure to adjudicate a criminal case in court of appeal became self-evident in COVID-19 emergency. The new legal and factual reality and the convenience which it brings, naturally brings forth the question about maintaining the possibility of judicial review of criminal proceedings in writing, in particular on the court of appeal, in cases not covered by the Criminal Procedure Law of Republic of Latvia. This raises the question whether, within the framework of fair proceedings, an appellate court may adjudicate a case in written procedure, if the court proceedings of the first instance had resulted in an acquittal.
Tiesību suverenitāte: idejas ietekme uz Latvijas tiesisko sistēmu
Authors:   Latvijas Universitāte, Pleps Jānis
Published: August 2024

The development of the principles of the rule of law required to harmonize this concept with the concept of sovereignty. For the purpose of solving dualism between sovereign state power and rule of law professor Hugo Krabbe (1857–1936) proposed the concept of the sovereignty of law. Sovereignty of law means that nobody in the democratic state governed by law, even sovereign itself, is not above the law. The law determines the competencies of all constitutional bodies and subordinates them to the principles of rule of law. The idea of Hugo Krabbe was well recognized and implemented in the Latvian legal system. That strengthened the principle of rule of law as one of the core elements of Latvian constitutional identity and foundation of Latvian legal system. It was recognized in the legal doctrine and in the jurisprudence of the Latvian Senate, that all constitutional bodies are subordinated to the law and no one in the Latvian legal system is outside or above the law.
Applying Principle of Equality in Case of Restriction of Rights
Authors:   University of Latvia, Briede Jautrite
Published: August 2024

The article analyses the practice of the Constitutional Court in the application of the principle of equality in cases where a legal norm establishes a restriction of rights. The article critically evaluates the fact that the court can declare a norm invalid only because a relevant restriction, which is otherwise necessary, appropriate and proportionate, has not been set for other persons who should have been subject to it. It is concluded that this can have serious negative consequences and violate the principle of rationality.
The Principle of Legality and General Crimes – the Particular Case of Abuse in Service of Public Officer
Authors:   West University of Timisoara, Nicorici Cristina
Published: August 2024

The principle of legality is a fundamental part of the criminal law system and a rule that is a part of the positive legislation in most of the countries. One of its components – the law – should state clearly, in a predictive and comprehensible manner, what actions or inaction constitute crimes. Many countries including Romania attempt to regulate and penalize, as precisely as possible in accordance with this principle, by the means stipulated in criminal law, the actions of public officers who fulfil their duties improperly, or fail to fulfil them, with the intention to cause damage to others. The current article considers the crime of abuse of office, – an incrimination that aims to define all types of conduct of a public officer that are not regulated by law as more specific crimes. However, such a general incrimination invariably is on the edge of the principle of legality. The aim of this article is to analyse the ways how the crime of abuse of office has been regarded in Romania in the latest years, in connection with the principle of legality.
The Non-Social Purpose of Private Law: A Reply to Otto von Gierke
Authors:   Freiburg University, Schaefer Frank L.
Published: August 2024

The reasons presented by Otto von Gierke in his famous speech “The Social Purpose of Private Law” for a hybridisation of private law towards a social private law are not convincing anymore. Private law is not intrinsically social. Rather, the protection of the weaker party, for example through redistribution, is attributed to public law. Therefore, the present social private law must be broken down into its two original components: free and market-oriented private law and public social law. Only if both spheres of law are principally, conceptually and systematically separated from each other, they are capable of playing out their full capacity.
Results of a Needs Assessment for a DEI Workshop for GME Program Coordinators
Authors: Rowland Kate , Anderson Lauren , Wright Katherine  M. , Twiss Megham , Eaton Jory , Gates Khalilah
Published: August 2024

Introduction: Competency in diversity, equity, and inclusion skills is critical for graduate medical education program coordinators. Coordinators contribute to high-level personnel and program management while also providing informal social support to residents. However, little has been reported about program coordinator learning needs, interest, and self-reported skills and attitudes regarding diversity, equity, and inclusion initiatives in graduate medical education. This study sought to describe the characteristics, job tasks, attitudes, and learning needs of program coordinators attending a professional development session about diversity, equity, and inclusion.
Methods: Participants registered for a September 2022 program coordinator professional development workshop on diversity, equity, inclusion, and bias were invited to complete an electronic needs assessment prior to the workshop. Items were based on expert opinion and literature review. We performed descriptive and comparative analysis.
Results: The response rate was 54% (106/198); 90% (94/104) of respondents identified as female; 42% (44/104) identified as an underrepresented minority. Fifty-seven percent (63/104) received mandatory training on bias while 13% (14/104) were previously trained on bias at a conference specific to the role of a coordinator. Eighty-nine percent (86/104) of coordinators reported having contact with applicants during recruiting; 67% (63/104) offer informal resident evaluations. Most participants agreed it is the coordinator’s professional responsibility to confront colleagues who display signs of discrimination toward women (66%; 62/104) or based on cultural/ethnic identity (65%; 61/104).
Conclusions: Program coordinators report visible and impactful roles in the residency leadership and management team. Few coordinators have received diversity, equity, and inclusion training related to their complex work in graduate medical education. Future graduate medical education diversity, equity, inclusion, and bias competency programs should specifically include program coordinators.
Efforts to Reduce Bias in Clerkship Evaluations: A CERA Study
Authors: Piazza Nina , Sanders Mechelle , Moreno Gerardo , Brown Elizabeth
Published: August 2024

Introduction: As the number of medical students who identify as underrepresented in medicine (URiM) increases, the disparities related to gender and URiM status persist. This study examines the current initiatives within family medicine clerkships to reduce bias in evaluations.
Methods: Our 10-item survey was included as a module in the 2022 Council of Academic Family Medicine Educational Research Alliance national survey of family medicine clerkship directors. Our survey questions asked about whether programs had strategies to reduce bias in student evaluations, antiracism initiatives, perceptions on effectiveness of the initiatives, and type and cadence of faculty development on evaluations for preceptors.
Results: The overall response rate for the survey was 59.12% (94/159); all respondents completed our module. Seventy percent said they had implemented strategies to reduce bias in evaluations, 60% felt these were effective, and 80% felt that reducing bias in evaluations was a priority. The majority, 89/91(95%), indicated that their medical schools had a current social justice, diversity, or antiracism initiative. We identified a positive association between specific antibias medical school initiatives and clerkship directors undertaking practices to reduce bias in evaluations (P=.005).
Conclusions: Most programs had implemented strategies to reduce bias and felt that doing so was a priority. Community-based preceptors were less likely to have faculty development around reducing bias compared to those in academics. Further improvements may need to prioritize including community preceptors in educational efforts to reduce bias.
El éxito académico universitario desde la percepción de autonomía de los estudiantes
Authors: Ahumada De La Rosa Vicky Del Rosario , Gamboa Mora María Cristina , Gutiérrez Álvarez María Deyser , Londoño Giraldo Eliana Patricia , Hernández López Fernando
Published: August 2024

El éxito académico universitario desde la percepción de autonomía de los estudiantes es un producto de nuevo conocimiento derivado del proyecto PG0401ECEDU2022 (Percepciones de los estudiantes de su autonomía y la incidencia en el éxito académico en la educación virtual) desarrollado por el Grupo de Investigación AMECI de la Universidad Nacional Abierta y a Distancia (UNAD) y el Grupo de Investigación Ingeniería, Ciencias Ambientales e Innovación de la Fundación Universitaria Católica del Norte (FUCN) en la Convocatoria para Grupos de investigación No. 10/2021 de la UNAD. Los resultados de estudios sobre las percepciones de autonomía han planteado que el éxito académico de los estudiantes en la educación superior virtual se relaciona con sus percepciones, su grado de satisfacción, su rendimiento y la persistencia que muestran cuando se mantienen activos en el sistema. Se trata de una investigación educativa desarrollada desde los enfoques cuantitativo y cualitativo, de diseño descriptivo y analítico de tipo correlacional, cuyo propósito fue determinar si la variable percepción de la autonomía se relaciona con el éxito académico de los estudiantes en programas virtuales. Mediante muestreo no probabilístico participaron 430 estudiantes (265 de la UNAD y 165 de la FUCN). Se aplicó la Escala Nivel de Autonomía (ENA) y se analizaron bases de datos con información del rendimiento académico (2022). Se calculó el coeficiente de correlación rho de Spearman (rs), se registraron correlaciones significativas entre las dimensiones medidas en la variable autonomía más no entre la autonomía y el éxito académico.
Association of dopamine receptor D2 -141C insertion/deletion and dopamine beta-hydroxylase 19 bp insertion/deletion polymorphisms with schizophrenia: A case-control study in the eastern Algerian population
Authors: Boukhenaf Yasmina , Sariyah Ayachi , Achou Rayene , Iness Bernou , Zohra Madoui , Sifi Karima , Larbi Rezgoun
Published: August 2024

Numerous studies emphasize genetic contributions to schizophrenia, particularly focusing on genes coding for proteins in the dopaminergic pathway, which are extensively studied for their involvement in the disorder?s pathophysiology. This investigation aimed to examine the potential association between the dopamine receptor D2 (DRD2) -141C insertion/ deletion (rs1799732) and the dopamine beta-hydroxylase (DBH) 19 bp insertion/deletion (rs72393728) polymorphisms with schizophrenia in an eastern Algerian population. A case-control study was conducted, involving 145 patients and 146 healthy controls. DNA samples were extracted from peripheral blood cells using the salting out technique. Genotyping for the DRD2 rs1799732 polymorphism was performed using the PCR-RFLP method, while the DBH rs72393728 polymorphism was analyzed using the PCR method. The results revealed a significant association between the DRD2 rs1799732 polymorphism and schizophrenia, evidenced by significant differences in genotypic and allelic distributions between patients and controls (P=0.001 and P=0.001, respectively). However, no statistical differences were found for the DBH rs72393728 polymorphism between patients and controls for genotype (P=0.46) or allele frequencies (P=0.73). This study supports an association between DRD2 rs1799732 polymorphism and schizophrenia in this population while finding no such association with DBH rs72393728 polymorphism. However, there may be a potential interaction between both polymorphisms.
Experimental investigation of low temperature combustion in a diesel engine depending on injection advance and injection pressure
Authors: Gezer Onur , Ozener Orkun , Ozkan Muammer
Published: August 2024

In this study, the performance parameters and emissions of a pre-mixed charge compression ignition were investigated under different injection pressures and injection advances. After the peak engine power was reached, reasonable decreases occurred in brake mean effective pressure at certain injection advances with the increase of injection advance, and dramatic decreases observed when interval was so exceeded. In addition mean indicated pressure and peak in-cylinder pressure were investigated. Considering the emissions, dramatic increases were observed in CO and total hydrocarbon, depending on the increase in the low temperature combustion regime. The NOx started a rapid downward trend after a certain injection advance value in the experimental region, but this effect did not occur at the de?sired level for specific NOx. It was observed that the NO2 to NOx ratio increased as the pre-mixed charge compression ignition became dominant and NO2 production increased among the total NOx. In the operating region where the low temperature combustion regime was dominant, the targeted reduction in NOx and particulate matter emissions was observed, but the desired reduction in specific emissions did not occur. In the low temperature combustion region, the combustion process was prolonged, initially reasonable changes occurred at performance parameters, but unacceptable results were observed at high injection pressures with excessive injection advances.
Effects of magnetism on porous rectangular fins with convection and radiation
Authors: Ullah Sharif , Algahtani Obaid , Din Zia , Ali Amir
Published: August 2024

A fin is an extended surface used to enhance the surface area of a heat transfer surface between a hot source and the outside environment. To maximise the rate of heat transportation, the exterior surface of heated equipment is equipped with fins of various geometries. Heat is exchanged using fins in radiators, refrigeration systems, superheaters, combustion engines, electrical equipment, electric transformers, space vehicles, and aircraft engines. Reflecting these applications, we analyse the effect of a magnetic field on the thermal properties of radiating porous rectangular fins. The proposed model is numerically analysed using the shooting method under the influence of radiation and convection, then compared with the DTM solution and both the solution found closer to each other. The effect of various dimensionless parameters on temperature transmission in magnetized rectangular-shaped porous fins is revealed using numerical results. It is revealed that, when the Raleigh, Hartmann, Peclet numbers, convective and radiative parameters increase, the fin?s thermal profile decreases, whereas the thermal profile increases with an increase in surface temperature, porosity, and ambient temperature. It is observed that the magnetic effect increases the heat transfer rate from porous rectangular fin surfaces. Accordingly, efficiency increases as Hartmann number, Raleigh number, and radiative parameter rise. Increasing Peclet number, surface temperature, and ambient temperature leads to a reduction in efficiency.
Energy consumption prediction of cement calcination process based on dual-channel temporal convolution neural
Authors: Wang Zijian , Kao Hongtao
Published: August 2024

The cement industry has consistently consumed large amounts of coal and electricity resources. Optimizing energy scheduling and production process control can typically save energy and improve production efficiency. Therefore, the prediction of energy consumption holds great significance in the cement industry and other energy-intensive sectors. However, predicting energy costs is challenging due to multiple production factors, variable coupling, and time lags. In this re-search, we proposed the use of a dual-channel temporal convolution neural network to forecast coal and electricity consumption in the cement calcination process for the upcoming production hour. Additionally, we employ the Spearman correlation coefficient method to select variables for the calcination system, aiming to reduce feature data dimensions and improve model training efficiency. To address parameter redundancy and mitigate the risk of overfitting, we devise a dual-channel structure. For comparison, we utilized various models including recurrent neural network, gate recurrent unit, long short-term memory, convolutional neural network, and back-propagation in prediction experiments using actual cement calcination process energy consumption data. The results indicated that with a kernel size of 13, dilation rates of [21, 22, ?, 26] and a filter size of 36, the temporal convolution neural model achieves an accuracy of 97.65%. Relative to other models, the temporal convolution neural model achieved a reduction of at least 40% and 24% in the mean squared error for coal and electricity consumption forecasts, respectively, meeting the expected requirements.
Maternal and Neonatal Efficacy and Safety Outcomes of Myo-inositol in Women With or at High Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Ahmed Ragab Ali Youssef , Mustafa Ibrahim Mustafa Sharara Muhannad , Mahmoud Abdelbary Tayeb Mostafa , Alaa Abdelhamid Elhefni Rezk Abdelrahman , Samy Ali Mohamed Elsayed Abuali Ahmed , Aly Seoudy Sedeik Aly Mohamed , Yousif Elnaghy Mohamed , Elsayed Mohammed Elsayed Elsekaily Ahmed , Elsayed Abdelrahman Elsayed Elkholy Mohammed , Mohamed Ragab Khaled , Mohamed Badawy Marwa , Hashem Fathallah Ahmed
Published: August 2024

To guarantee the healthy development of a fetus, a woman’s metabolism and hormones undergo essential changes throughout pregnancy (1). Insulin production increases with gestational age to better feed the growing fetus with glucose. However, this state can increase the chance of the woman developing gestational diabetes mellitus (GDM) if the increased insulin production is not well regulated by insulin secretion from increased β-cell mass and responsiveness (2). Pregnancy-onset glucose intolerance of any severity that does not meet the criteria for full-blown diabetes is considered to be GDM (3). A growing number of pregnant women are experiencing difficulties such as preeclampsia and are having babies with complications such as macrosomia, hyperbilirubinemia, newborn hypoglycemia, and the need for admission to the neonatal intensive care unit (NICU) because of this condition (4,5).
Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease
Authors: Zhong Jing , Ji Xiuyu , Zhao Yali , Jia Yihe , Song Churui , Lv Jinghuan , Chen Yuying , Zhou Yanping , Lv Xue , Yang Zhuoyin , Zhang Zheyu , Xu Qiyao , Wang Weihong , Chen Haiyan , Cui Aoyuan , Li Yu , Meng Zhuo-Xian
Published: August 2024

Abstract

Overnutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progression remains poorly understood. Here, we identified hepatic BAF60b as a lipid-sensitive subunit of the switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complex and is negatively associated with liver steatosis in mice and humans. Hepatic BAF60b deficiency promotes high-fat diet (HFD)-induced liver steatosis in mice, while transgenic expression of BAF60b in the liver attenuates HFD-induced obesity and NAFLD, both accompanied by a marked regulation of PPARγ expression. Mechanistically, through motif analysis of liver ATAC-Seq and multiple validation experiments, we identified CCAAT/enhancer‐binding protein β (C/EBPβ) as the transcription factor that interacts with BAF60b to suppress PPARγ gene expression, thereby controlling hepatic lipid accumulation and NAFLD progression. This work uncovers hepatic BAF60b as a negative regulator of liver steatosis through C/EBPβ dependent chromatin remodeling.

Keyword：SWI/SNF complex; BAF60b; NAFLD; Transcriptional regulation

Article Highlights

• We aim to understand how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progression.

• Hepatic BAF60b is a dietary-lipid sensor and is negatively associated with liver steatosis. We used liver-specific BAF60b knockout and transgenic mice, combining with multi-omics techniques, to study the role of BAF60b in NAFLD progression.

• Our findings uncover BAF60b as a key chromatin remodeling checkpoint factor in controlling hepatic lipid sensing, accumulation, and NAFLD progression through engaging the C/EBPβ/PPARγ axis.
Distressed personality is associated with late adverse effects in long-term survivors of Hodgkin lymphoma
Authors: Dahl Alv A. , Smeland Knut B. , Eikeland Siri , Fagerli Unn-Merete , Bersvendsen Hanne S. , Fosså Alexander , Kiserud Cecilie E.
Published: August 2024

Background and purpose: There are few studies of personality traits in long-term Hodgkin lymphoma survivors (HLSs) treated according to contemporary stage-and risk-adapted approaches. The Distressed Personality (DP) Scale covers negative affectivity and social inhibition. We examined differences in self-reported late adverse effects (LAEs) between HLSs with and without DP and other explanatory variables.
Material and methods: This cross-sectional questionnaire-based study included a population-based cohort of HLSs treated from 1997 to 2006, aged 8–49 years at diagnosis, and alive in 2016. Among 518 eligible HLSs, 303 responded (58%), and 294 completed the DP scale. DP was defined by scores above cut-off on both the negative affectivity and social inhibition subscales. LAEs studied were major depression, posttraumatic stress disorder, sleep problems, obesity, neuropathy, fatigue, memory problems, and general health. DP and 10 other explanatory variables were tested against LAEs as dependent variables in multivariable regression analyses.
Results: The mean age at survey was 45.9 years (standard deviation [SD] 4.6), mean follow-up time 16.7 years (SD 3.0), and 48% were females. Eighty-two HLSs had DP (28%, 95% confidence interval 23% – 33%). All LAEs except obesity were significantly more common/had higher mean score in HLSs with DP. In multivariable analyses, presence of DP was significantly associated with all LAEs except obesity.
Interpretation: The presence of DP is common among HLSs. The presence of DP was associated with most self-report LAEs examined. Including assessment of personality traits in the survivorship care plans of HLSs should be considered. Prospective studies assessing the influence of pretreatment DP on LAEs are warranted.
Treatment outcomes and prognostic factors in nonmetastatic metaplastic breast cancer patients: a multicenter retrospective cohort study
Authors: Püsküllüoğlu Mirosława , Konieczna Aleksandra , Świderska Katarzyna , Streb Joanna , Pieniążek Małgorzata , Grela-Wojewoda Aleksandra , Pacholczak-Madej Renata , Mucha-Małecka Anna , Mituś Jerzy W. , Szpor Joanna , Kunkiel Michał , Rudzińska Agnieszka , Jarząb Michał , Ziobro Marek
Published: August 2024

Background and purpose: Metaplastic breast carcinoma (BC-Mp) is an uncommon subtype that poses unique challenges. The limited information on patient prognosis and therapeutic strategies motivated our research initiative. We aimed to assess disease-free survival (DFS), overall survival (OS), and influential factors in patients with nonmetastatic BC-Mp.
Materials and methods: In this multicenter retrospective cohort study, clinicopathological data for nonmetastatic BC-Mp patients treated at four oncology units in Poland (2012–2022) were gathered.
Results: Among 115 women (median age 61, range: 28–91), the median tumor size was 40 mm (range 20–130); 30% of patients exhibited positive local lymph nodes. The majority of patients presented with stage II (46%) and triple-negative breast cancer (TNBC) (84%). Radiotherapy was administered to 61% of patients. Surgical procedures included breast-conserving surgery in 31% of patients and mastectomy in 68%. Eighty-three per cent of patients received chemotherapy. The median estimated DFS and OS were 59 and 68 months, respectively. Multivariable analysis revealed that tumor size influenced DFS and OS (Hazard ratios [HR] = 1.02, 95%CI 0.01–0.03 for both endpoints) and taxanes application improved DFS (HR = 0.47, 95%CI 0.24–0.93), but other factors did not. For patients receiving neoadjuvant systemic therapy (N = 51), taxanes improved DFS and OS according to univariable analysis.
Interpretation: Our findings highlight poor DFS and OS regardless of receiving optimal treatment, emphasizing the need for tailored therapeutic strategies for BC-Mp patients. Taxanes appear promising in a neoadjuvant setting, particularly within the current standard of care for the TNBC subtype.
Spontaneous Mucocutaneous Ulcerations: A Quiz
Authors: Drivenes Jakob L. , Bygum Anette
Published: August 2024

Abstract is missing (Quiz)
Mapping the costs and socioeconomic characteristics involved in traumatic brain injuries: a scoping review
Authors: Crozes Fanny , Delpierre Cyrille , Costa Nadège
Published: August 2024

Objective: To identify the articles in the existing literature that analyse healthcare costs according to the socioeconomic position (pre- or post-injury) for traumatic brain injury survivors. Secondary aims were to describe the types of costs and socioeconomic characteristics and to determine whether socioeconomic characteristics affect the risk of traumatic brain injury or whether the consequences of trauma alter living conditions post-injury.
Methods: This scoping review followed the methods proposed by Arksey and O’Malley. The literature search was performed in 5 databases.
Results: Twenty-two articles were included, published between 1988 and 2023. Only 2 articles (9%) followed the guidelines for economic evaluation of healthcare programmes and 2 articles (9%) evaluated socioeconomic position “completely” with 3 main individual measures of socioeconomic characteristics (i.e., education, income, and occupation). The relationship between costs and socioeconomic characteristics could vary in 2 ways in traumatic brain injury: socioeconomic disadvantage was mostly associated with higher healthcare costs, and the cost of healthcare reduced the survivors’ living conditions.
Conclusion: This work highlights the need for a detailed and methodologically sound assessment of the relationship between socioeconomic characteristics and the costs associated with trauma. Modelling the care pathways of traumatic brain injury would make it possible to identify populations at risk of poor recovery or deterioration following a TBI, and to develop specific care pathways. The aim is to build more appropriate, effective, and equitable care programmes.
Rehabilitation interventions for neuropathic pain: a systematic review and meta-analysis of randomized controlled trials
Authors: Bäckryd Emmanuel , Ghafouri Nazdar , Gerdle Björn , Dragioti Elena
Published: August 2024

Objective: Rehabilitation interventions for chronic pain typically include education, cognitive behavioural therapy, and exercise therapy, or a combination of these. A systematic review and meta-analysis of rehabilitation interventions for neuropathic pain was conducted.
Design: Randomized controlled trials were identified in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and PsycINFO databases from inception up to 3 March 2022.
Subjects/Patients: Adults with chronic (> 3 months) neuropathic pain.
Methods: Primary outcomes were pain intensity, pain-related disability, and work participation. Secondary outcomes were quality of life, emotional strain, insomnia, and adverse outcomes, according to VAPAIN guidelines. Analyses were made post-intervention, which was defined as the assessment point immediately following the intervention or at the first-time measurement conducted after the intervention period.
Results: In total, 15 studies (total population, n = 764) were incorporated. Most common interventions were cognitive behavioural programmes including acceptance and commitment therapy (n = 4), mindfulness-based interventions (n = 5), and yoga (n  =  2). Psychological interventions reduced both pain intensity (SMD –0.49, 95% CI –0.88 to –0.10) and pain-related disability (SMD –0.51, 95% CI –0.98 to –0.03), whereas other interventions had an effect on pain intensity but not on pain-related disability.
Conclusion: Rehabilitation interventions, and psychological interventions in particular, seem to be of value for patients with chronic neuropathic pain.
Game Edukasi “Atman” Pada Materi Nilai Tempat Bilangan Cacah Siswa Kelas IV Sekolah Dasar
Authors: Ida Ayu Mas Intariani  , Ni Wayan Rati  , I Gede Margunayasa
Published: August 2024

Matematika sering dipandang sebagai mata pelajaran yang sulit, membosankan dan menakutkan bagi siswa sehingga berdampak pada hasil belajar yang rendah. Penelitian ini bertujuan untuk mengembangkan game edukasi “ATMAN” pada materi nilai tempat bilangan cacah sampai 10.000 siswa kelas IV SD. Subjek uji coba pada penelitian ini adalah 3 orang dosen ahli materi dan materi, 1 orang guru kelas IV dan siswa kelas IV SD. Objek dalam penelitian ini adalah validitas, kepraktisan penggunaan, serta tingkat efektivitas media game edukasi “ATMAN”. Penelitian ini menggunakan model ADDIE. Metode pengumpulan data dilakukan dengan dan tes. Teknik analisis data menggunakan analisis kuantitatif dan analisis deskriptif kualitatif. Hasil penelitian pengembangan ini yaitu: rancang bangun yang sesuai, dengan tingkat validitas, kepraktisan, dan efektivitas yang tinggi. Berdasarkan hal tersebut, dapat disimpulkan bahwa media game edukasi “ATMAN” valid dan layak digunakan untuk mengatasi kesulitan pembelajaran dalam materi nilai tempat bilangan cacah, dengan diimbangi oleh nilai-nilai karakter yang dapat ditemukan ketika siswa memainkan game edukasi “ATMAN”. Penelitian ini berimplikasi pada meningkatnya hasil belajar siswa setelah menggunakan game edukasi dan menjadi referensi bagi guru untuk mengembangkan media pembelajaran yang lebih inovatif serta dapat membantu siswa dalam kegiatan pembelajaran.
E-LKPD Berbasis Model OPPEMEI Untuk Meningkatkan Hasil Belajar IPAS Kelas IV
Authors: Kadek Aprilia Sri Wulandari  , Putu Ari Dharmayanti
Published: August 2024

Penelitian ini dilatarbelakangi atas masalah kurangnya pemanfaatan bahan ajar digital dalam pelaksanaan pembelajaran dan hasil belajar siswa yang masih rendah. Tujuan penelitian ini adalah mengembangkan E-LKPD berbasis model OPPEMEI untuk meningkatkan hasil belajar IPAS kelas IV. Jenis penelitian ini merupakan penelitian pengembangan dengan menggunakan model ADDIE. Subjek dari pengembangan adalah E-LKPD berbasis model OPPEMEI dan objek pengembangan yaitu validitas, kepraktisan dan efektivitas dari E-LKPD yang dikembangkan. Metode pengumpulan data pada penelitian ini menggunakan wawancara, kusioner dan tes. Hasil Penelitian pengembangan E-LKPD berbasis model OPPEMEI menunjukan bahwa validitas ahli materi 0,93, ahli desain 1,00, dan ahli media pembelajaran 0,95. Hasil kepraktisan dari uji perorangan mendapatkan 95,83%, uji coba kelompok kecil mendaptkan 91,20%. Hasil uji-t menunjukan 11,38 lebih besar dari nilai t-tabel. Uji N-gain score data prettest dan posttest didapatkan 71% termasuk dalam kategori cukup efektif. Disimpulkan bahwa pengembangan E-LKPD berbasis model OPPEMEI valid, praktis dan cukup efektif diterapkan pada muatan IPA untuk meningkatkan hasil belajar kognitif siswa. Implikasi penelitian ini adalah E-LKPD berbasis model OPPEMEI dapat membantu guru dalam pelaksanaan pembelajaran.
Implementation of Narrative Essay Learning Strategies for Elementary School Writing Level
Authors: Astutik Dwi Widi , Kusumaningrum Shirly Rizki , Dewi Radeni Sukma Indra , Anggraini Ade Eka , Mardhatillah
Published: August 2024

Writing narrative essays is one of the language skills that elementary school students must have. The use of interesting methods and media is used to stimulate students to develop narrative essay storylines. Several variations of learning strategies are offered so that students can develop their writing skills. This research aims to analyze learning strategies for writing narrative essays that are suitable for use in elementary schools. This research uses a qualitative method with a case study approach. The population of this research was carried out on class IV students as a data source. Data collection techniques include document analysis, questionnaires, observations and interviews. Based on the research results, the strategies used in learning to write narrative essays are not appropriate. Students have not been able to develop sentences in narrative essays based on the series of pictures presented. Lack of practice and lack of interest in reading are the dominant reasons why students are weak in writing.  The implications of this research are can provide new insights for teachers in designing and implementing writing lessons that are more effective and interesting for students. With narrative essay strategies, students can more easily develop their critical thinking skills and creativity through telling personal or imaginative experiences.
Media Pop Up Book Berbasis Kontekstual Muatan Matematika Materi Bangun Ruang
Authors: Nila Ni Komang Ayu Nilawati , Gusti Ngurah Sastra Agustika  , I Wayan Wiarta
Published: August 2024

Hasil belajar matematika di Indonesia masih terbilang rendah. Rendahnya hasil belajar dikarenakan kurangnya kreativitas yang dilakukan oleh siswa dalam menyerap, mengatur, serta mengolah informasi dalam pembelajaran yang diberikan oleh guru, hal ini disebabakan karena kurang tepatnya pemilihan media dan gaya belajar. Penelitian ini bertujuan untuk menganalisis media pop up book berbasis kontekstual muatan matematika materi bangun ruang pada siswa kelas II SD. Penelitian ini menggunakan model pengembangan ADDIE. Metode pengumpulan data yang digunakan yaitu tes objektif pilihan ganda serta kuesioner dan teknik analisis data yang digunakan yaitu kualitatif dan kuantitatif. Hasil penelitian adalah Rancang bangun media telah sesuai dengan tahapan pengembangan ADDIE, kelayakan media menunjukkan hasil uji ahli isi muatan pelajaran Matematika sebesar 93,33% (Sangat Baik), uji ahli desain instruksional sebesar 95% (Sangat Baik), uji ahli media pembelajaran sebesar 91,66% (Sangat Baik), uji coba perorangan sebesar 90,83% (Sangat Baik), dan uji coba kelompok kecil sebesar 93,33% (Sangat Baik). Hasil uji efektivitas diperoleh H0 ditolak dan Ha diterima, nilai post-test siswa lebih besar dari KKTP. Disimpulkan bahwa media pop up book berbasis kontekstual efektif diterapkan pada muatan matematika materi bangun ruang pada siswa kelas II SD. Implikasi penelitian ini siswa dapat meningkatkan kemampuan mereka dan dapat memahami materi dengan bantuan berbagai media.
Media Pembelajaran E-Komik Berbasis Kearifan Lokal Pada Mata Pelajaran Bahasa Indonesia Siswa Kelas V Sekolah Dasar
Authors: Kadek Icahayati  , Kadek Yudiana  , Gusti Ayu Putu Sukma Trisna
Published: August 2024

Pembelajaran bahasa Indonesia di sekolah dasar dianggap sebagai mata pelajaran yang membosankan bagi siswa. Maka dari itu guru harus menghadirkan pembelajaran bahasa Indonesia yang menyenangkan. Namun kenyataannya guru belum mampu menghadirkan pembelajaran bahasa Indonesia yang menyenangkan. Penelitian ini bertujuan untuk menciptakan menciptakan media pembelajaran e-komik berbasis kearifan lokal pada mata pelajaran Bahasa Indonesia siswa Kelas V Sekolah Dasar. Penelitian ini merupakan penelitian pengembangan menggunakan model ADDIE. Subjek pada penelitian ini adalah 2 ahli isi materi, 2 ahli media pembelajaran, 2 guru praktisi dan 31 orang siswa. Metode yang digunakan yaitu kuisioner dengan memberikan angket berupa instrumen lembar penilaian. Teknik analisis data menggunakan analisis kuantitatif dan kualitatif. Hasil penelitian menunjukkan penilaian aspek materi mendapatkan skor 96,16 %. Validasi ahli media mendapatkan skor 96,16 %. Persentase tersebut berada pada rentangan 90 – 100 % dan validasi respon praktisi mendapatkan skor 97,78 %. Validasi respon siswa yang sudah dirata-ratakan mendapatkan skor 92,42 %. Berdasarkan penilaian skala lima skor tersebut menunjukkan kualifikasi sangat baik, yang berarti media e-komik berbasis kearifan lokal layak digunakan. Simpulan penelitian menunjukkan media e-komik berbasis kearifan lokal mendapat kualifikasi sangat baik. Implikasi penelitian ini melalui media E-komik siswa dapat membangun pengetahuan intelektual, mendukung visualisasi dan interpretasi materi pembelajaran.
Kunjungan Lapangan Bermain Messy Play dan Kemampuan Sosial Untuk Mengoptimalkan Kecerdasan Naturalis Anak
Authors: Zeptyani Ditha , Putu Aditya Antara  , I Gede Astawan
Published: August 2024

Kecerdasan naturalis anak masih sangat rendah, karena pembelajaran berbasis alam masih belum dilakukan. Tujuan penelitian ini yaitu menganalisis kunjungan Lapangan Bermain Messy Play dan Kemampuan Sosial terhadap kecerdasan naturalis anak. Metode penelitian yang digunakan adalah quasi experiment dengan desain post-test only control group. Populasi penelitian adalah 106 anak. Pengambilan sampel menggunakan teknik cluster random sampling sebanyak 44 anak. Metode pengumpulan data menggunakan teknik non tes berupa kuesioner. Teknik analisis data menggunakan teknik analisis ANAVA dua jalur berbantuan aplikasi SPSS. Hasil penelitian yaitu pertama, terdapat perbedaan kecerdasan naturalis antara kelompok yang menerapkan metode Kunjungan Lapangan melalui bermain Messy Play dengan kelompok yang menerapkan metode konvensional. Kedua, terdapat interaksi antara metode Kunjungan Lapangan melalui bermain Messy Play dan kemampuan sosial secara bersama terhadap kecerdasan naturalis anak. Ketiga, pada anak yang memiliki kemampuan sosial tinggi, terdapat perbedaan kecerdasan naturalis antara kelompok yang menerapkan metode Kunjungan Lapangan melalui bermain Messy Play dengan kelompok yang menerapkan metode konvensional. Disimpulkan kunjungan Lapangan Bermain Messy Play dan Kemampuan Sosial dapat meingkatkan kecerdasan naturalis anak. Implikasi penelitian ini adalah hasil penelitian ini dapat memberikan panduan praktis bagi para pendidik dan orang tua dalam merancang kegiatan pembelajaran yang lebih interaktif dan berfokus pada pengalaman langsung dengan alam.
Influence of Growth Regulators on Growth, Seed Yield and Qualty of Radish (Raphanus sativus L.)
Authors: Bala R. , Rattan P. , Reddy A. H.
Published: August 2024

The present investigation was carried out during 2021 at the experimental farm of Faculty of Agricultural Sciences, DAV University, Jalandhar. Radish is an important crop of Punjab region. Use of Plant Growth Regulators is one of the most recent trends in the field of agriculture science. Plant growth regulators are signal molecules, which occurs in plants naturally in very low concentration. In an attempt to find out the influence of growth regulators on growth, seed yield and quality of radish (Raphanus sativus L.) the experiment was planned and executed. It consisted of nine treatments viz., T1 (Control), T2 (GA3 @ 5 ppm), T3 (GA3 @ 10 ppm), T4 (GA3 @ 15 ppm), T5 (GA3 @ 20 ppm), T6 (NAA @ 5 ppm), T7 (NAA @ 10 ppm), T8 (NAA @ 15 ppm), T9 (NAA @ 20 ppm) and was laid in Randomized block design (RBD) with three replications. Punjab Safed Mooli variety was used for the experiment. Observations were recorded on number of leaves per plant, leaf area per plant (cm2), root length (cm), root diameter (cm), root weight (g), fresh weight of plant (g), dry weight of plant (g), plant height (cm), 100 seed weight (g), seed yield plant-1 (g), seed yield plot-1 (g), seed yield ha-1 (q ha-1), TSS (°Brix), ascorbic acid (mg 100 g-1), chlorophyll content (mg 100 g-1) and germination percentage (%). Analysis of variance (ANOVA) revealed significantly differences among treatments for all the characters under study. It was concluded that the application of GA3 @ 20 ppm showed superior performance in all growth, seed yield and quality parameters of radish.
Air Pollution, Obesity and Disease
Authors: Zeliger Harold I.
Published: August 2024

Ninety-nine per cent of the world’s population breathes polluted air and thirty-eight per cent (and growing) of the human population is obese. Both air pollution (AP) and obesity (OBS) are known to cause many of the same diseases in humans via similar oxidative stress (OS) driven mechanisms. Air pollution is a known cause of obesity, which serves to compound disease impact. The commonly produced disease impacts of air pollution and obesity and their mechanisms of action are addressed. Also discussed are early disease onset and the mutagenic and evolutionary impacts of both AP and OBS.