bluuebunny/crossref_metadata_2025 huggingface dataset:
Aprendizaje móvil: habilidad de los estudiantes universitarios como parte de la evolución de las TIC
Authors: Mejía-Burgos Oscar , Zúñiga-Alvarado María , Orellana-Ingriago Fernando , Barzola-López Luis
Published: April 2023

El objetivo de esta investigación se basó en analizar el prendizaje móvil como una habilidad de los estudiantes universitarios como parte de la evolución de las TIC, a través de una metodología cuantitativa apoyada en la ivestigación bibliográfica y documental, la muestra estuvo conformada por 60 estudiantes del segundo semestre de la carrera de Contaduría Publica Autorizada. Obteniendo como resuultados que los estudiantes materializando el principio de “aprender a aprender” se centra en su autonomía y a través del uso de las plataformas virtuales el estudiante presta la debida atención a las actividades que realiza para lograr una retroalimentación, asimismo, los estudiantes al ser capaces de utilizar la internet como apoyo de sus estudios, procuran buscar tutoriales acerca del manejo de dichas plataformas y no quedarse solo con lo explicado en sus cursos de inducción que generalmente brinda la universidad permitiendo así que puedan reconocer los menús de la plataforma y ubicarse en tiempo y espacio dentro de la misma. Como conclusión se menciona que los estudiantes de educación superior han adquirido con el paso del tiempo conocimientos y habilidades móviles que le han hecho ser partícipes directos de la evolución de las TIC´s logrando aspectos relevantes en su formación educativa, del mismo modo las universidades durante y después del COVID-19 han logrado avanzar en gran medida en cuanto a la implementación de plataformas que llegaron para quedarse, sobre todo en aquellas universidades tradicionales que no disponían de estos recursos, pues es necesario reconocer que lo juventud de hoy día manejan diferentes equipos tecnológicos que utilizan para apoyarse en su formación profesional.
La verdad como Derecho Constitucional en el ordenamiento jurídico ecuatoriano
Authors: Vargas-Arcos  Jairo , Vargas-Villacrés Borman , Vargas-Arcos Gissela
Published: April 2023

Las sociedades desde sus inicios se han preocupado por entender y comprender determinados fenómenos sean estos físicos, sociales o biológicos, con lo cual interviene el raciocinio del ser humano que se preocupa por dar un significado a todas estas manifestaciones. La preocupación se genera en admitir un acto o un hecho como algo valedero que sea aceptado por todos los congéneres, para que tenga una categoría de admisibilidad y si bien se discuta su presencia, ésta sea al menos considerada por una mayoría. Así empieza la existencia de la verdad que tiene significados variados dependiendo de su origen semántico, pero que todos ellos empiezan por desentrañar la esencia de un objeto o de una exteriorización, pero a la vez son condiciones de convivencia social y hasta una forma de alcanzar la libertad. Claro está, que el ideal filosófico es precisamente que exista una correspondencia entre la concepción humana y el objeto que se analiza; pero este esfuerzo no es fácil, al contrario, dependerá inclusive del criterio subjetivo de cada individuo.
Evaluación de calidad educativa a través del modelo servqual en la carrera de turismo de la UFA-ESPEL
Authors: Molina-Herrera Jenny , Parreño-Herrera Inés
Published: April 2023

El presente estudio tuvo el objetivo de evaluar la calidad del servicio de educación en la carrera de turismo mediante la aplicación del modelo SERVQUAL para el reconocimiento de las percepciones que tienen los estudiantes para el mejoramiento del entorno de la calidad del servicio de la Universidad de las Fuerzas Armadas ESPE sede Latacunga (UFA-ESPEL). Los datos se recopilaron mediante un cuestionario estructurado que contenía elementos de percepción basada en la escala SERVQUAL para adaptación a la perspectiva de educación superior. Los datos recopilados fueron obtenidos de una muestra de 191 ​​estudiantes de la facultad. Los componentes del constructo fueron: tangibles, calidad del servicio, confiabilidad, responsabilidad, seguridad, y empatía. El método de análisis estadístico utilizado fue el análisis factorial exploratorio. Los hallazgos revelaron que la seguridad es el componente que destacó en el conglomerado, puesto que, los estudiantes al rodearse en un entorno militar comprenden que los cuidados hacia los grupos de interés de la organización, tanto a nivel personal como tecnológicos serán más confortables. La conclusión investigativa demostró que existe relación teórica como estadística entre la calidad del servicio y la satisfacción del estudiante. Sin embargo, los coeficientes de correlación demostraron niveles moderados, por lo cual, deben realizarse procesos continuos de gestión de la calidad de los servicios universitarios.
Evaluación del comportamiento de los indicadores de gestión financiera. Caso de Estudio: Universidad de las Fuerzas Armadas, Sede Latacunga
Authors: Moyano-Barahona Juan , Veloz-Jaramillo Marco
Published: April 2023

Las instituciones de educación superior bajo todos los diferentes niveles de dependencia económica están expuestas a desafíos extraordinarios, como: los recursos limitados y el costo creciente de brindar educación superior. Por ello, el objetivo del presente estudio fue analizar el comportamiento de la gestión financiera mediante la aplicación de los indicadores financieros para el reconocimiento del estado económico de la Universidad de las Fuerzas Armadas, Sede Latacunga para el periodo 2019-2021. Se aplicó el método de enfoque cuantitativo y alcance correlacional mediante el análisis de los indicadores de liquidez, gestión, rentabilidad y endeudamiento, puesto que, fueron relacionados mediante el coeficiente R de Pearson. Los resultados obtenidos demostraron altos niveles de liquidez, mientras que, los demás indicadores tuvieron resultados mínimos acorde a la premonición de que la institución es pública sin fines de lucro y brinda servicio de educación superior. De tal manera se concluyó que, los indicadores de endeudamiento y rentabilidad tuvieron resultados mínimos, mientras que, la liquidez para los años 2020 y 2021 fue extremadamente alta, lo cual indicó que no hubo inversión en la institución y pudo deberse al efecto del Covid-19 y las clases virtuales, lo que provocó un retraso en el cumplimiento de actividades destinadas para el campus
Understanding the Master’s Degree Research Supervision at Community Campuses of Nepal
Authors: Puri Gobinda
Published: April 2023

Research supervision has become increasingly demanding for graduate students towards the successful completion of their research. However, there are limited studies on how supervisors supervise the research students and what their experiences are in the context of Nepalese higher education. This phenomenological qualitative study explores the Master’s degree research supervisors’ perceptions and their lived experiences on supervision of Master’s thesis. Thematically analysing the data collected from six purposively sampled supervisors of three public campuses of Nepal, this paper reports the findings that research supervision practices in community campuses of Nepal lack sociocultural pedagogic practice for developing research skills in the students. Furthermore, it examines the supervisors’ roles, supervisor-student relationship, and the challenges the supervisors faced during research supervision. In this paper, I argue that the research supervisory process in Nepal needs to be socioculturally situated for producing independent researchers.
Sosyal Medya ile Değişen Mahremiyet: Z Kuşağındaki Öğrencilerin Mahremiyet Algısı Üzerine Bir Araştırma
Authors: KARAHİSAR Tüba , HAYIR Celal
Published: April 2023

Bu çalışmada Jürgen Habermas, Hannah Arendt ve Richard Sennett’in kamusal alan kavramından yola çıkılarak sosyal medyadaki mahremiyet, özel alan kavramları incelenmiştir. Makalede amaç, katılımcıların mahremiyet kavramından haberdar olup olmadıklarının, hangi konularda hassas davranış sergilediklerinin, hangi saiklerle sosyal medyada paylaşım yaptıklarının, hassas veri paylaşmaktan endişe duyup duymadıklarının ortaya çıkarılmasıdır. Bu amaç doğrultusunda çalışmanın veri toplama yöntemi ankettir. Anket, Google Form aracılığı ile internet ortamında hazırlanmış ve katılımcılara sosyal medya uygulamaları (Whatsapp ve Facebook) ile ulaştırılmıştır. Anket, uygulanmadan önce bir denek grubu üzerinde test edilmiştir. Araştırmanın evreni 1995 sonrası doğan Z kuşağına mensup bireyler, örneklemi ise Uşak Üniversitesi İletişim Fakültesi öğrencileridir. Verilerin analizinde SPSS 26.0 paket programı kullanılmıştır. Araştırma sonuçlarına göre katılımcıların tamamına yakınının mahremiyet kavramından haberdar olduğu ve herhangi birini sosyal medyada zor duruma düşürecek paylaşımlarda bulunmadıkları ve çoğunluğunun sosyal medyada mahremiyet ihlâli durumunda ne yapmaları gerektiğini bildikleri görülmüştür. Katılımcıların mahremiyet algısı orta düzeyde çıkmıştır.
Retro-reflektif tekstiller
Authors: BİLİR Mehmet Zahit
Published: April 2023

Teknik tekstiller son yıllarda kullanımı giderek artan ve estetik özelliklerden daha çok fonksiyonellik özellikleriyle ön plana çıkan özel ürünlerdir. Bu nedenle teknik tekstiller birçok sektöre hitap edebilen ürünleri yapısında bulundurmaktadır. Retro-reflektif tekstiller, teknik tekstiller içerisinde yer almakta olup, özellikle iş güvenliği uygulamalarında kullanılmaktadır. Bu çalışmada teknik tekstiller ve retro-reflektif tekstiller hakkında bilgi verilmiş ve daha sonra retro-reflektif iplik kullanılarak örnek bir tasarım uygulaması yapılmıştır. Yapılan bu örnek tasarım uygulamasına ait üretim aşamaları da paylaşılmıştır. Günümüz Dünyasında giderek artan rekabet koşullarında tüm sektörlerin ayakta kalabilmesi ve daha yüksek kâr oranlarının yakalanabilmesi için retro-reflektif gibi inovatif ve tasarım açılarından genişlemeye müsait olan yeni malzemelerden yararlanılabilmesi son derece önemlidir. Bu çalışmayla tekstil alanında çalışan kişilerin retro-reflektif tekstil uygulamaları hakkında daha çok bilgi sahibi olması ve yapılacak olan tekstil tasarımlarında katma değeri daha yüksek olabilen retro-reflektif ürünlere daha çok yer verilmesinin sağlanması hedeflenmektedir.
The Effect of Pester Power Variables on Parents' Decision to Buy Ice Cream Brand Walls at Alfamart Sriwijaya - Mataram
Authors: Oktiani Asri , Suastina I Gusti Putu Bagus , Syafhariawan Herry
Published: April 2023

The purpose of this study was to determine whether pester power which consists of peer influence variables, emotional pestering, persuasive pestering on parents' decisions to buy ice cream walls. Data collection was obtained from questionnaires distributed to 101 respondents obtained by the accidental sampling method. Respondents are parents of children aged 3-9 years who purchase ice cream walls from October to December 2021. This study is quantitative and uses SPSS 23 to process primary data obtained from respondents' answers. From the results of the study, it was found that all variables in the study had a significant influence on parents' decisions both simultaneously and partially and the Emotional Pestering variable became the dominant variable.
Openness Muhammadiyah to Women Leader in Amal Usaha Muhammadiyah Kota Pekalongan
Authors: Susanti Leni , Kurniati Panca , Dewi Alfa Yuliana
Published: April 2023

Muhammadiyah as harokah manages about being allowed for a woman to participate in organizational activities. At present, many women can lead well. This research conducted to find out how much Muhammadiyah's openness towards the acceptance of women as leaders at Muhammadiyah Charity Foundation owned by Muhammadiyah in Pekalongan. This research is a descriptive quantitative research that is an approach to test objective theory by examining the relationship between variables that describe the response and level of acceptance of Muhammadiyah to female leaders in AUM Pekalongan. Respondents in this study were 24 AUMs in Pekalongan with total sampling or census techniques because of all existing samples were used. The analytical tool is Import Performance Analysis. This research found that women leaders should be concerned in quadrant II. It means that the approaches have been used optimally by leaders to lead their employees or subordinates to achieve the organization’s goals.
Analisis Dampak Pandemi Covid-19 Terhadap Pendapatan Pengusaha Mebel JeparaA
Authors: Fatimatuzzahroh Siti
Published: April 2023

Dampak Covid-19 pada ekonomi ini berdampak luas di seluruh wilayah indonesia, perekonomian masing-masing daerah terancam ditambah dengan kondisi daerah yang lebih buruk dari sebelumnya Penelitian ini meneliti tentang dampak Covid-19 terhadap pendapatan pengusha mebel Jepara dengan variabel X modal, tenaga kerja dan bahan baku dan variabel Y adalah pendapatan. Penelitian ini menggunakan metode kuantitatif. Sampel dalam penelitian ini adalah 88 responden yang mewakili pengusaha mebel di Jepara. Hasil penelitian menunjukkan bahwa nilai t hitung masing-masing variabel bebas adalah 2,129 untuk Modal, 5,838 untuk variabel Bahan Baku. Didapatkan t tabel 1,662 (t hitung > t tabel) artinya variabel modal dan bahan baku berpengaruh positif dan signifikan terhadap pendapatan pengusaha mebel Jepara. Sedangkan untuk variabel Tenaga Kerja sebesar 0,285 (t hitung < t tabel) yang berarti variabel Tenaga Kerja tidak berpengaruh positif tidak signifikan terhadap pendapatan pengusaha mebel Jepara.
Relevansi Doktrin Trinitas dalam Menganalisis Budaya
Authors: Harianja Doni Herwanto
Published: April 2023

Artikel ini mengkaji teologi budaya menurut pandangan Lesslie Newbigin dan Johan Herman Bavinck. Dikatakan bahwa kerangka trinitas adalah kerangka yang tepat dalam membaca dan menganalisis budaya. Dengan merujuk kedua tokoh ini dan membandingkannya maka penulis memperlihatkan aplikasi kerangka trinitas untuk membaca dan menganalisis budaya dalam pemikiran Newbigin dan Bavinck. Dari kajian ini, penulis memperlihatkan keragaman teologi budaya dari tradisi teologi Reformed yang dapat diaplikasikan khususnya dalam kehidupan bermasyarakat yang majemuk.
Birleşik Krallık Dergisi The Week’te Yayınlanan Rusya-Ukrayna Savaşı’na Dair Karikatür Temsiller
Authors: KARAKAŞ A. Vildan , YILMAZ Mutlu
Published: April 2023

Karikatürler, kimi zaman kitleleri harekete geçirmek için kimi zaman iktidarı, erki ve güçlü olanı eleştirmek, hicvetmek için kullanılan anlam ve temsil araçlarıdır. Özelliklerine göre farklı çeşitleri bulunan karikatürler arasında en fazla dikkat çekenlerden birisi de politik karikatürlerdir. Politik karikatürler, siyasi hayata dair yaşananları eleştirel bakış açısıyla görselleştirerek kamuoyuna aktarmak için kullanılmaktadır. Eleştirel jeopolitik içerisinde popüler jeopolitik çalışmalarda tercih edilen söz konusu karikatürler, topluma sunulan bilgide önemli veri araçları olarak karşımıza çıkmaktadır. Bu çalışmada Birleşik Krallık Dergisi The Week haber ajansında yer alan Rusya-Ukrayna Savaşı’na dair kullanılan politik karikatürler doküman analizi ile yorumlanmıştır. Araştırmanın bulgularına göre ayı figürü ile özleştirilen Rusya’nın Ukrayna Savaşı’nda askeri kapasitesi yetersiz biçimde ve Putin'in mesafeli ve nezaketsiz bir politikacı imajıyla aktarıldığı görülmüştür. Dergide yayınlanan karikatürlerin Ukrayna algısı ise, ülkede yaşananların dramatik boyutunu ortaya koyar niteliktedir. Görsel temsillerde ülke sakinlerinin başlarının dertte olduğu, kurtarılmayı bekleyen, yardıma muhtaç insanlar olarak gerçeğe daha yakın temsillerle aktarıldığı görülmüştür.
Glaucoma primario de ángulo cerrado
Authors: Vargas-Gonzales Enrique , Vargas Chang Patricia
Published: April 2023

El glaucoma primario de ángulo cerrado es una patología ocular que en su forma de presentación aguda que puede comprometer significativamente la capacidad visual del paciente. El cuadro clínico puede presentar síntomas sistémicos como cefalea, náuseas y vómitos, similar a un cuadro de migraña. Por ello es de suma importancia identificar aquellos síntomas y signos que nos pueden guiar a reconocer o sospechar de esta patología para poder instaurar un tratamiento inicial y poder derivarlo oportunamente al especialista.
Role of Media in Social Change
Authors: Aryal Deb Raj
Published: May 2023

The concept that media has an effective role in social change is a complex question in itself. However, as the media is directly connected with lives of people, it is necessary to focus on this subject-area. This study has been presented on the basis of the ground of mass communication and principles of the media and review- analysis of previous studies in this sector. Media content and messages have a deep impact on the mood of readers, sources and viewers. Consequently, the person's concept, perspective and field of thought are affected. Eventually, because of this the individual's behavior will change and in overall scenes of change appear in the society. In the past few years, the number of media in Nepal has been growing exponentially, and our society is not immune to the changes caused by the influence of media.
The Meaning (בַיִת) Of The House In Psalm 127:1
Authors: Theo Sahara
Published: May 2023

The title of this research is the meaning (בַיִת) of the house in Psalm 127:1. "The purpose of this research is to explain the meaning of the phrase "house/baby" as a building structure and as a family in Psalm 127:1. The author uses exegesis studies, in grammatical studies, semantic studies and interpretations related to Biblical Counseling. There are two meanings as a conclusion in this study: first, the house is defined as a building structure (the temple, David's palace, building), and second, the house is a family, a household. Psalm 127 warns that every building of home and family involves and relies on God.
The Evaluation of Soteriology in Inclusivist Theology
Authors: Pasaribu Goktondi
Published: May 2023

The theology of inclusivism is one of the three theological approaches in the study of religion. This approach was proposed by Alan Race in his discourse on the relationship between religions. Inclusivism holds a concept of salvation that combines or reconciles the concept of salvation from two other theological approaches, namely exclusivism and pluralism. Exclusivism takes a firm stance and asserts that salvation is only through Jesus as mentioned in the Scriptures. On the other hand, pluralism believes that all religions are valid, and none is superior to the other. Inclusivist theology brings both together by stating that salvation is only possible through Jesus Christ; thus, the requirement for belief is to believe in Jesus. However, other religions can also receive salvation because they have access to Jesus through general revelation. People who attain salvation without believing in Jesus but have access to him through general revelation are called anonymous Christians, namely, brothers at the very margins. This concept is highly demanded by many people, including Christians, as it is more reasonable and tolerant. How does this concept of inclusivity in salvation align with the biblical perspective? This research is a qualitative study that will examine the truth of the concept of inclusivism based on the exegesis of three verses, namely John 14:6, Acts 4:12, and 1 Timothy 2:15.
Upaya Pencegahan Stunting melalui Kegiatan Posyandu Desa Sungai Manau, Kecamatan Kuantan Mudik, Provinsi Riau
Authors: Fauza Naila , Prandima Augika Faghas , Taufiq P. Ahmad , Arfisan Amdan , Arnanda Gega , Herninandari Anisa , Hardianti Lesti , Rani Mutia Mustika , Sari Nilam , Deflides Viani Ghefira , Gusmarinda Yola
Published: May 2023

Children aged five and under are included in the high-risk category for experiencing impaired growth and physical development if nutritional problems occur. Malnutrition and health problems that commonly occur in children include malnutrition, obesity, and below normal body posture or stunting. One of the efforts that can be made in early detection and prevention of stunting is through Posyandu activities. The University of Riau real work team took part in community service through routine toddler posyandu activities and conducted research to determine the level of knowledge of mothers of toddlers regarding stunting in Sungai Manau village. This service activity is in line with research which aims to find out and increase mother's knowledge about stunting. This activity uses the health education method for mothers with toddlers on August 9, 2022 at the Posyandu in Sungai Manau village. Through this activity it was found that the majority of mothers' knowledge regarding stunting was in the medium category (57%). During the evaluation, it was found that the majority of mothers could answer questions about stunting correctly. We hope that this service activity could be continued with different interventions such as the use of local food resources to overcome stunting in children.
Integrative proteomic profiling of lung tissues and blood in acute respiratory distress syndrome
Authors: Gong Rui , Luo Hong , Long Gangyu , Xu Jiqian , Huang Chaolin , Zhou Xin , Shang You , Zhang Dingyu
Published: May 2023

Introduction

Acute respiratory distress syndrome and acute lung injury (ARDS/ALI) still lack a recognized diagnostic test and pharmacologic treatments that target the underlying pathology.

Methods

To explore the sensitive non-invasive biomarkers associated with pathological changes in the lung of direct ARDS/ALI, we performed an integrative proteomic analysis of lung and blood samples from lipopolysaccharide (LPS)-induced ARDS mice and COVID-19-related ARDS patients. The common differentially expressed proteins (DEPs) were identified based on combined proteomic analysis of serum and lung samples in direct ARDS mice model. The clinical value of the common DEPs was validated in lung and plasma proteomics in cases of COVID-19-related ARDS.

Results

We identified 368 DEPs in serum and 504 in lung samples from LPS-induced ARDS mice. Gene ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEPs in lung tissues were primarily enriched in pathways, including IL-17 and B cell receptor signaling pathways, and the response to stimuli. In contrast, DEPs in the serum were mostly involved in metabolic pathways and cellular processes. Through network analysis of protein-protein interactions (PPI), we identified diverse clusters of DEPs in the lung and serum samples. We further identified 50 commonly upregulated and 10 commonly downregulated DEPs in the lung and serum samples. Internal validation with a parallel-reacted monitor (PRM) and external validation in the Gene Expression Omnibus (GEO) datasets further showed these confirmed DEPs. We then validated these proteins in the proteomics of patients with ARDS and identified six proteins (HP, LTA4H, S100A9, SAA1, SAA2, and SERPINA3) with good clinical diagnostic and prognostic value.

Discussion

These proteins can be viewed as sensitive and non-invasive biomarkers associated with lung pathological changes in the blood and could potentially serve as targets for the early detection and treatment of direct ARDS especially in hyperinflammatory subphenotype.
Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection
Authors: Duncan Joseph K. Sampson , Xu Danyang , Licursi Maria , Joyce Michael A. , Saffran Holly A. , Liu Kaiwen , Gohda Jin , Tyrrell D. Lorne , Kawaguchi Yasushi , Hirasawa Kensuke
Published: May 2023

Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, antiviral roles of IRFs during human coronavirus infection are not fully understood. Type I or II IFN treatment protected MRC5 cells from human coronavirus 229E infection, but not OC43. Cells infected with 229E or OC43 upregulated ISGs, indicating that antiviral transcription is not suppressed. Antiviral IRFs, IRF1, IRF3 and IRF7, were activated in cells infected with 229E, OC43 or severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). RNAi knockdown and overexpression of IRFs demonstrated that IRF1 and IRF3 have antiviral properties against OC43, while IRF3 and IRF7 are effective in restricting 229E infection. IRF3 activation effectively promotes transcription of antiviral genes during OC43 or 229E infection. Our study suggests that IRFs may be effective antiviral regulators against human coronavirus infection.
Camrelizumab plus gemcitabine and oxaliplatin for the treatment of advanced intrahepatic cholangiocarcinoma: a bi-centric observational retrospective study
Authors: Zhang Yu-Qing , Wang Kang , Feng Jin-Kai , Yuan Lu-Yun , Liang Chao , Xiang Yan-Jun , Wang Xu , Mao Fei-Fei , Cheng Shu-Qun
Published: May 2023

Background

Immune checkpoint inhibitor (ICI), coupled with systemic chemotherapy, may enhance the clinical benefit of cancer by potentiating antitumor immunity, but its efficacy and safety are not clear in advanced intrahepatic cholangiocarcinoma (ICC). This study aims to assess the efficacy and safety of camrelizumab plus gemcitabine and oxaliplatin (GEMOX) for the treatment of advanced ICC in the real world.

Methods

Advanced ICC patients receiving at least one session of camrelizumab plus GEMOX combination treatment from March 2020 to February 2022 at two high-volume centers were considered eligible. Tumor response was evaluated based on the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1). The primary endpoint was objective response rate (ORR), disease control rate (DCR), time to response (TTR), and duration of response (DOR). The secondary end points included overall survival (OS), progression-free survival (PFS), and treatment-related adverse events (TRAEs).

Results

30 eligible ICC patients were enrolled and analyzed in this observational retrospective study. The median follow-up time was 24.0 (21.5–26.5) months. The ORR and DCR were 40% and 73.3%, respectively. The median TTR was 2.4 months and the median DOR was 5.0 months. The median PFS and OS were 7.5 months and 17.0 months, respectively. The most common TRAEs were fever (83.3%), fatigue (73.3%), and nausea (70%). Of all TRAEs, thrombocytopenia, and neutropenia were the most frequent severe AE (both 10%).

Conclusion

The combination of camrelizumab and GEMOX is a potentially efficacious and safe treatment modality for advanced ICC patients. Potential biomarkers are needed to identify patients who might benefit from this treatment option.
Identifying key transcription factors and immune infiltration in non-small-cell lung cancer using weighted correlation network and Cox regression analyses
Authors: Zhang Jingyao , Wang Yinuo , Yuan Baowen , Qin Hao , Wang Yong , Yu Hefen , Teng Xu , Yang Yunkai , Zou Jun , Zhang Min , Huang Wei , Wang Yan
Published: May 2023

Introduction

Lung cancer is one of the most common cancers and a significant cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. Therefore, it is crucial to identify effective diagnostic and therapeutic methods. In addition, transcription factors are essential for eukaryotic cells to regulate their gene expression, and aberrant expression transcription factors are an important step in the process of oncogenesis in NSCLC.

Methods

Differentially expressed transcription factors between NSCLC and normal tissues by analyzing mRNA profiling from The Cancer Genome Atlas (TCGA) database program were identified. Weighted correlation network analysis (WGCNA) and line plot of least absolute shrinkage and selection operator (LASSO) were performed to find prognosis-related transcription factors. The cellular functions of transcription factors were performed by 5-ethynyl-2'-deoxyuridine (EdU) assay, wound healing assay, cell invasion assay in lung cancer cells.

Results

We identified 725 differentially expressed transcription factors between NSCLC and normal tissues. Three highly related modules for survival were discovered, and transcription factors highly associated with survival were obtained by using WGCNA. Then line plot of LASSO was applied to screen transcription factors related to prognosis and build a prognostic model. Consequently, SETDB2, SNAI3, SCML4, and ZNF540 were identified as prognosis-related transcription factors and validated in multiple databases. The low expression of these hub genes in NSCLC was associated with poor prognosis. The deletions of both SETDB2 and SNAI3 were found to promote proliferation, invasion, and stemness in lung cancer cells. Furthermore, there were significant differences in the proportions of 22 immune cells between the high- and low-score groups.

Discussion

Therefore, our study identified the transcription factors involved in regulating NSCLC, and we constructed a panel for the prediction of prognosis and immune infiltration to inform the clinical application of transcription factor analysis in the prevention and treatment of NSCLC.
Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
Authors: Liu Fei , Xu Qing , Regmi Parbatraj , Li Fu-Yu , Lin Yi-Xin
Published: May 2023

Background

Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein–Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of specific features regarding the laboratory test results and imaging findings. At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To our knowledge, only few cases of LEL-ICC have been reported in the literature.

Case presentation

We presented a case of a 32-year-old Chinese female with LEL-ICC. She had a 6-month history of upper abdominal pain. The magnetic resonance imaging (MRI) showed a 1.1× 1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The patient underwent laparoscopic left lateral sectionectomy. The postoperative histopathologic and immunohistochemical examinations results allowed for the definitive diagnosis of LEL-ICC. The patient was free from tumor recurrence after a 28 months follow-up.

Conclusion

In this study, we reported a rare case of LEL-ICC associated with both HBV and EBV infection. EBV infection might play a pivotal role in the carcinogenesis of LEL-ICC, and surgical resection is still the most effective treatment at present. Further research on the etiology and treatment strategies of LEL-ICC is required.
B-cell lymphoblastic lymphoma following intravenous BNT162b2 mRNA booster in a BALB/c mouse: A case report
Authors: Eens Sander , Van Hecke Manon , Favere Kasper , Tousseyn Thomas , Guns Pieter-Jan , Roskams Tania , Heidbuchel Hein
Published: May 2023

Unprecedented immunization campaigns have been rolled out worldwide in an attempt to contain the ongoing COVID-19 pandemic. Multiple vaccines were brought to the market, among two utilizing novel messenger ribonucleic acid technology. Despite their undisputed success in decreasing COVID-19-associated hospitalizations and mortality, various adverse events have been reported. The emergence of malignant lymphoma is one of such rare adverse events that has raised concern, although an understanding of the mechanisms potentially involved remains lacking. Herein, we present the first case of B-cell lymphoblastic lymphoma following intravenous high-dose mRNA COVID-19 vaccination (BNT162b2) in a BALB/c mouse. Two days following booster vaccination (i.e., 16 days after prime), at only 14 weeks of age, our animal suffered spontaneous death with marked organomegaly and diffuse malignant infiltration of multiple extranodal organs (heart, lung, liver, kidney, spleen) by lymphoid neoplasm. Immunohistochemical examination revealed organ sections positive for CD19, terminal deoxynucleotidyl transferase, and c-MYC, compatible with a B-cell lymphoblastic lymphoma immunophenotype. Our murine case adds to previous clinical reports on malignant lymphoma development following novel mRNA COVID-19 vaccination, although a demonstration of direct causality remains difficult. Extra vigilance is required, with conscientious reporting of similar cases and a further investigation of the mechanisms of action explaining the aforementioned association.
Case Report: Infectious prophylaxis in hematological malignancies
Authors: Passucci Mauro , Masucci Chiara , Paoletti Francesca , Ielo Claudia , Costa Alessandro , Carmosino Ida , Scalzulli Emilia , Martelli Maurizio , Gentile Giuseppe , Breccia Massimo
Published: May 2023

Patients with hematological malignancies and past serological evidence of hepatitis B are at risk for HBV reactivation. In myeloproliferative neoplasms, continuous treatment with the JAK 1/2 inhibitor ruxolitinib confers a moderate risk of reactivation (1-10%); nevertheless, no prospective randomized data are available to strongly recommend HBV prophylaxis in these patients. Here, we report a case of primary myelofibrosis and past serological evidence of HBV infection, treated with ruxolitinib and concomitant lamivudine, developing HBV reactivation due to premature withdrawal of prophylaxis. This case underlines the potential need for persistent HBV prophylaxis in the setting of ruxolitinib treatment.
A Mayfly-Based Approach for CMOS Inverter Design with Symmetrical Switching
Authors: Zghoul Fadi Nessir , Alteehi Haneen , Abuelrub Ahmad
Published: May 2023

This paper presents a novel approach to designing a CMOS inverter using the Mayfly Optimization Algorithm (MA). The MA is utilized in this paper to obtain symmetrical switching of the inverter, which is crucial in many digital electronic circuits. The MA method is found to have a fast convergence rate compared to other optimization methods, such as the Symbiotic Organisms Search (SOS), Particle Swarm Optimization (PSO), and Differential Evolution (DE). A total of eight different sets of design parameters and criteria were analyzed in Case I, and the results confirmed compatibility between the MA and Spice techniques. The maximum discrepancy in fall time across all design sets was found to be 2.075711 ns. In Case II, the objective was to create a symmetrical inverter with identical fall and rise times. The difference in fall and rise times was minimized based on Spice simulations, with the maximum difference measuring 0.9784731 ns. In Case III, the CMOS inverter was designed to achieve symmetrical fall and rise times as well as propagation delays. The Spice simulation results demonstrated that symmetry had been successfully achieved, with the minimum difference measuring 0.312893 ns and the maximum difference measuring 1.076540 ns. These Spice simulation results are consistent with the MA results. The results conclude that the MA is a reliable and simple optimization technique and can be used in similar electronic topologies.
Effects of Water Supply Mode on Nitrogen Transformation and Ammonia Oxidation Microorganisms in a Tea Garden
Authors: Wang Heng , Hou Jian , Zhou Bo , Han Xiaoyang
Published: May 2023

Drought limits tea yield and can also negatively impact its quality. In this study, constant humidity and dry–wet alternating modes were compared to determine their impacts on soil nitrogen transformation and ammonia-oxidizing microorganisms. Drought was found to reduce the soil NH4+-N concentration under the constant humidity mode, and the NO3−-N concentration was highest in 60% water-holding capacity (WHC) soil. Soil NO3−-N content increased rapidly after rewatering, and increasing the frequency of dry–wet watering resulted in a higher accumulation of NO3−-N. In the constant humidity mode, drought reduced the abundance of ammonia-oxidizing archaea (AOA), whereas that of ammonite-oxidizing bacteria (AOB) increased. Increases in drought duration and the frequency of dry–wet watering inhibited the activity of AOA under the dry–wet alternating mode, whereas the relative activity of AOB increased after rehydration. The water supply mode did not change the community structure of AOA or AOB at the genus level but affected their relative abundance. In the constant humidity mode, the contribution rate of AOA to nitrification potential (PNR) was 42.75–49.72%, whereas that of AOB was 50.28–57.25%. In the dry–wet alternating mode, the contribution rate of AOA to PNR increased, and the contribution rate of AOB decreased. Taken together, these findings indicate that ammonia oxidation might be primarily driven by AOA and AOB in weakly acidic and neutral soil. This study reveals the effects of different water supply modes on soil nitrogen transformation and ammonia-oxidizing micro-organisms and provides a scientific basis for improving nitrogen use efficiency.
Artificial Intelligence Integrated GIS for Land Suitability Assessment of Wheat Crop Growth in Arid Zones to Sustain Food Security
Authors: El Behairy Radwa A. , Arwash Hasnaa M. El , El Baroudy Ahmed A. , Ibrahim Mahmoud M. , Mohamed Elsayed Said , Rebouh Nazih Y. , Shokr Mohamed S.
Published: May 2023

Developing countries all over the world face numerous difficulties with regard to food security. The purpose of this research is to develop a new approach for evaluating wheat’s suitability for cultivation. To this end, geographical information systems (GIS) and fuzzy inference systems (FIS) are used as the most appropriate artificial intelligence (AI) tools. Outcomes of investigations carried out in the western Nile Delta, Egypt. The fuzzy inference system used was Mamdani type. The membership functions used in this work are sigmoidal, Gaussian, and zmf membership. The inputs in this research are chemical, physical, and fertility soil indices. To predict the final soil suitability using FIS, it is required to implement 81 IF-THEN rules that were written by some experts. The obtained results show the effectiveness of FIS in predicting the wheat crop’s suitability compared to conventional methods. The research region is split into four classes: around 241.3 km2 is highly suitable for wheat growth, and 224 km2 is defined as having moderate suitability. The third soil suitability class (low), which comprises 252.73 km2, is larger than the unsuitable class, which comprises 40 km2. The method given here can be easily applied again in an arid region. Decision-makers may benefit from the research’s quantitative findings.
Deciphering Chitosan–Host Plant Interaction in Esca Disease
Authors: Martín Laura , Millán Agustín , Castaño Francisco Javier , Fontaine Florence
Published: May 2023

The production of wine and table grapes is hampered by Phaeomoniella chlamydospora, a fungus related to Petri diseases and Esca, two of the major grapevine trunk diseases causing the death of vines all over the world. This study analyses the effect of a commercial-based substance (chitosan hydrochloride 2.5%) on grapevine–P. chlamydospore interaction. Two experimental scenarios were evaluated: (i) root application in a greenhouse-plant model system and (ii) foliar application in an open-field environment (Tempranillo grape cultivar). Vascular necrosis and pathogen recovery were reduced after chitosan application. The treatment increased root development and the flavonoid index. On open-field application, the treatment did not significantly help decrease the expression of the foliar symptoms of Esca. In symptomatic leaves, the results revealed a lower overexpression of defence-related genes (Chit 1b, CHV5, STS and PR6) in plants treated with chitosan than in nontreated vines. Altogether, this study attempts to provide a first insight into the potential role of chitosan hydrochloride in the treatment of P. chlamydospora and the interaction on the control of the Esca–pathosystem complex. Differences were found between the root and foliar spraying modes of action.
Ruff Morning? The Use of Environmental Enrichment during an Acute Stressor in Kenneled Shelter Dogs
Authors: Dare Pamela , Strasser Rosemary
Published: May 2023

The length of stay for some animals has increased with the recent reduction of animals euthanized in US shelters and animal control facilities. Research examining the effectiveness of different types of enrichment on buffering the effects of acute daily stressors in the shelter environment, such as kennel cleaning, is lacking. In addition, daily known stressors can result in undesirable behaviors that could lead to a need for euthanasia. Ways to effectively reduce the effects of daily stressors while optimizing strained resources is currently a high priority. In this study, we presented shelter dogs with food, tactile, and scent enrichment items to increase (arousing) or decrease (calming) activity during the daily stressor of morning kennel cleaning. We found that calming, rather than arousing, enrichment items were associated with body position scores indicative of lower stress in dogs, with calming scent enrichment (lavender) producing the most significant benefit. In contrast, items that showed the greatest reduction in vocalization were arousing (ball) compared to other arousing conditions. Our findings suggest that different unwanted behaviors in the kennel environment often associated with stress can be reduced using specific types of enrichment during a daily stressful event. Further, the results illustrate that enrichment items other than food might be more effective at decreasing certain undesirable behaviors. Overall, this study provides insight into how shelter workers might effectively use enrichment items during an unavoidable acute stressor. With many shelters keeping dogs longer, addressing events that might cause repeated stress in this population may indirectly help with adopting and lowering euthanasia rates due to unwanted behavior that develops due to repeated exposure to this necessary but acute stressor of morning cleaning.
Development of an Inactivated Camelpox Vaccine from Attenuated Camelpox Virus Strain: Safety and Protection in Camels
Authors: Zhugunissov Kuandyk , Mambetaliyev Muratbay , Sarsenkulova Nuraiym , Tabys Shalkar , Kenzhebaeva Marzhan , Issimov Arman , Abduraimov Yergali
Published: May 2023

This article describes the preparation of an inactivated vaccine from an attenuated strain of camelpox. The attenuated camelpox virus (CMLV) was grown in lamb kidney cells and in Vero cells. CMLV was accumulated to a significantly higher (p ≤ 0.05) titer in lamb kidney cells (7.75 ± 0.08 log TCID50/mL) than in Vero cells (4.00 ± 0.14 log TCID50/mL). During virus inactivation, a concentration of 0.05% beta-propiolactone (BPL) completely inactivated the virus in 6 h at a temperature of 22 ± 1 °C, while a concentration of 0.2% formaldehyde inactivated the virus in 8 h. However, a viral antigen inactivated by BPL was used for vaccine preparation. The inactivated viral antigen was adsorbed with aluminum hydroxide gel, and as a result, an inactivated candidate vaccine was prepared. While the safety of the candidate vaccine was tested in camels and white mice, the protective efficacy of the vaccine was tested only in camels. In the safety evaluation of the inactivated vaccine, the vaccine was not observed to cause any adverse effects in mice and camels. During the immunogenicity study in camels, antibody formation started (0.2 ± 0.16 log2) at Day 21 post-vaccination (PV), and the antibody titer peaked (1.33 ± 0.21 log2) at Day 60 PV and decreased at Day 90 PV (0.50 ± 0.22 log2). Furthermore, no antibodies were detected in vaccinated camels from Days 180 to 365 PV. Camels that received vaccination and were subsequently exposed to wild-type virus evinced a healthy state despite lacking antibodies. In contrast, unvaccinated camels exhibited susceptibility to camelpox upon challenge.
Outcome of Communication Training in Veterinary Studies: Influence on the Perception of the Relevance of Veterinary Competencies and Self-Assessment of Communication Skills
Authors: Bahramsoltani Mahtab , Bröer Sonja , Langforth Susann , Eule Corinna , Prior Alina , Vogt Lena , Li Ting-Ting , Schirone Rebecca , Pohl Alina , Jensen Katharina Charlotte
Published: May 2023

Since communication skills contribute significantly to professional success among veterinarians, there is a particular focus on developing communication classes in veterinary curricula. At Freie Universität Berlin, an e-learning course covering the basics of communication and a practical communication course based on role plays with and without simulation persons have been established. The outcome of these communication courses on the assessment of the relevance of several veterinary competencies and on the self-assessment of communication skills using the SE-12 questionnaire was investigated. For this purpose, students were surveyed before and after the e-learning course as well as before and after the practical course. Veterinarians were also surveyed on the relevance of veterinary competencies. The relevance of communicative competencies for professional success was rated significantly higher by the students after completing the practical course than by the other students and the veterinarians. Self-assessment of communication skills showed little increase after the e-learning course, but a significant increase after the practical course. Thus, an effective outcome of the communication classes was observed mainly after the practical course. However, the effect of the e-learning course cannot be ruled out since the students participating in the practical course have also completed the e-learning course beforehand.
MRI Anatomical Investigation of Rabbit Bulbourethral Glands
Authors: Dimitrov Rosen , Stamatova-Yovcheva Kamelia
Published: May 2023

Anatomical MRI is appropriate for the interpretation of soft tissue findings in the retroperitoneal part of the pelvic cavity. The aim of the current study was to use rabbits as an imaging model to optimize MRI protocols for the investigation of bulbourethral glands. The research was conducted on twelve clinically healthy, sexually mature male rabbits, eight months of age (New Zealand White), weighing 2.8 kg to 3.2 kg. Tunnel MRI equipment was used. The transverse MRI in the T2-weighted sequence obtained detailed images that were of higher anatomical contrast than those in T1-weighted sequences. The hyperintensity of the glandular findings at T2, compared to the adjacent soft tissues, was due to the content of secretory fluids. The quality of the anatomical tissue contrast has not shown much dependence on the choice of the sequence in dorsal MRI. The sagittal visualization of the rabbit bulbourethral glands corresponded to the localization of the research plane toward a median plane. The imaging results could be used as a morphological base for clinical practice and reproduction.