bluuebunny/crossref_metadata_2025 huggingface dataset:
Long‐term effects of a preventive intervention on multiple components of adolescents' emotional insecurity
Authors: Hoegler Dennis Sarah , Vetterly Savannah , Cummings E. Mark
Published: May 2024

A gap in research on family interventions is the understanding of long‐term effects on hypothesized mechanisms of effect regarding children's processes of responding to family stressors. This study assessed the long‐term effects of an intervention designed to improve interparental and family conflict resolution on adolescents' emotional insecurity about interparental conflict. Emotional insecurity about interparental conflict has long been linked with adolescents' risk for adjustment problems. These findings have motivated the development of several family‐based preventive interventions, one of which is the focus of this study. A community sample of 225 adolescents and their parents participated in an RCT‐based study of an intervention designed to reduce adolescent's emotional insecurity about interparental conflict. The intervention's effect on patterns of change in adolescents', mothers', and fathers' reports of the three components of adolescents' emotional insecurity (emotional reactivity, behavioral dysregulation, and cognitive representations) from posttest through the 3‐year follow‐up were examined using multilevel modeling. Results suggested that the intervention predicted immediate (pre to posttest) and long‐term linear decreases in emotional reactivity, as well as long‐term quadratic change in behavioral dysregulation. These findings support the beneficial effects of a brief intervention on multiple components of emotional security. The results also underscore the importance of considering the potential of long‐term (including nonlinear) patterns of change that may occur as a function of family‐based interventions, as well as that the impact of family‐based interventions may vary as a function of reporter and component of emotional insecurity.
Tree contributions to climate change adaptation through reduced cattle heat stress and benefits to milk and beef production
Authors: Richards Daniel , Dewhurst Zachary , Giltrap Donna , Lavorel Sandra
Published: May 2024

Cattle heat stress causes billions of dollars' worth of losses to meat and milk production globally, and is projected to become more severe in the future due to climate change. Tree establishment in pastoral livestock systems holds potential to reduce cattle heat stress and thus provide nature‐based adaptation. We developed a general model for the impact of trees on cattle heat stress, which can project milk and meat production under future climate scenarios at varying spatial scales. The model incorporates the key microclimate mechanisms influenced by trees, including shade, air temperature, humidity, and wind speed. We conducted sensitivity analyses to demonstrate the relative influence of different mechanisms through which trees can impact cattle heat stress, and how tree impacts are influenced by climatic context globally. Trees hold the greatest potential to reduce cattle heat stress in higher latitudes and altitudes, with minor benefits in the lowland tropics. We projected the future contributions of current trees in mitigating climate change impacts on the dairy and beef herds of Aotearoa—New Zealand (A‐NZ) in 2070–2080. Trees were simulated to contribute to A‐NZ milk yields by over 491 million liters (lower CI = 112 million liters, upper CI = 850 million liters), and meat yields by over 8316 tonnes (lower CI = 2431 tonnes, upper CI = 13,668 tonnes) annually. The total economic contribution of existing trees in mitigating future cattle heat stress was valued at $US 244 million (lower CI = $US 58 million, upper CI = $US 419 million). Our findings demonstrate the importance of existing trees in pastoral landscapes and suggest that strategic tree establishment can be a valuable adaptation option for reducing cattle heat stress under climate change. Tree establishment in the next few years is critical to provide adaptation capacity and economic benefit in future decades.
Corrigendum to “Statistical Perspective on the Petrological Utility of Polyphase Groundmass Compositions Inferred via Defocused Beam Electron Probe Microanalysis” [Geostandards and Geoanalytical Research (2024)]
Authors: Coulthard Daniel A. , Iizuka Yoshiyuki , Zellmer Georg F. , Brahm Raimundo
Published: May 2024

Due to the incorrect speciation of iron during thermometry modelling, Coulthard et al. (2024) produced an incorrect olivine‐liquid equilibrium diagram, which failed to identify multiple potential equilibrium olivine‐melt pairs. With the new pairs identified here, the temperatures inferred from olivine‐groundmass pairs move closer in temperature space to those inferred from olivine‐glass pairs. Additionally, it is recognised that the most significant difference between these thermometry data is due to differences in inferred melt water mass fraction. If a mean value of water is used for all thermometry, the mean temperatures calculated for olivine‐glass and olivine‐groundmass pairs converge to within 10 °C of one another. This indicates that groundmass compositions inferred via the defocused beam analysis of a polyphase groundmass may reproduce enough information to confidently perform olivine‐melt thermometry despite the glass and groundmass data representing significantly different compositions in multivariate space.
Development of a Plasminogen Population PK model supporting prophylactic replacement therapy for Plasminogen deficient patients within the WAPPS‐Hemo platform
Authors: Chelle Pierre , Hajducek Dagmar , Thibaudeau Karen , Hobson Nicholas , Iorio Alfonso , Shapiro Amy , Edginton Andrea
Published: May 2024

Introduction

Plasminogen deficiency is an ultra rare disease whose patients may develop ligneous lesions if untreated. Prophylactic replacement therapy with plasma derived plasminogen, Ryplazim, is efficient in treating lesions and could benefit from pharmacokinetic (PK) tailoring.

Aim

The objectives of this study are to develop, evaluate and integrate into the WAPPS‐Hemo platform a Population PK model supporting prophylactic replacement therapy for Plasminogen deficient patients.

Methods

Population PK modelling and evaluations followed the same protocol performed for factor VIII and IX concentrates. Limited sampling analysis used dosing and sampling scenarios in accordance with recommended treatment for Ryplazim.

Results

The population PK model, derived from 16 participants included in previous clinical studies, was a 2‐compartment model whose variability was best described by fat‐free mass. Evaluations showed that the model described well the data and Bayesian forecasting in limited sampling environment led to acceptable precision for PK parameters relevant to plasminogen treatment.

Conclusion

The model was integrated into the WAPPS‐Hemo webservice to help individualize prophylactic treatment in plasminogen deficient patients. Prospective PK data to be collected through the WAPPS‐Hemo database will be used to better understand plasminogen PK and improve patient care.
Prevalence and burden of migraine in the United States: A systematic review
Authors: Cohen Fred , Brooks Caroline V. , Sun Daniel , Buse Dawn C. , Reed Michael L. , Fanning Kristina M. , Lipton Richard B.
Published: May 2024

Background

This study reviewed migraine prevalence and disability gathered through epidemiologic survey studies in the United States conducted over the past three decades. We summarized these studies and evaluated changing patterns of disease prevalence and disability.

Methods

We conducted a systematic review of US studies addressing the prevalence, disability, and/or burden of migraine, including both episodic migraine (EM) and chronic migraine (CM). A Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) protocol was used in conjunction with the PubMed search engine. Eligible studies were published before February 2022, were conducted in the United States, included representative samples, and used a case definition of migraine based on the International Classification of Headache Disorders (ICHD). The primary measure of disease burden was the Migraine Disability Assessment Scale (MIDAS). The MIDAS measures days lost due to migraine over 3 months in three domains and defines groups with moderate (Grade III) or severe disability (Grade IV) using cut‐scores.

Results

Of the 1609 identified records, 26 publications from 11 US population‐based studies met eligibility criteria. The prevalence of migraine in the population has remained relatively consistent for the past 30 years: ranging from 11.7% to 14.7% overall, 17.1% to 19.2% in women, and 5.6% to 7.2% in men in the studies reviewed. CM prevalence is 0.91% (1.3% among women and 0.5% of men) in adults and 0.8% in adolescents. The proportion of people with migraine and moderate‐to‐severe MIDAS disability (Grades III–IV), has trended upward across studies from 22.0% in 2005 to 39.0% in 2012, to 43.2% in 2016, and 42.4% in 2018. A consistently higher proportion of women were assigned MIDAS Grades III/IV relative to men.

Conclusion

The prevalence of migraine in the United States has remained stable over the past three decades while migraine‐related disability has increased. The disability trend could reflect changes in reporting, study methodology, social and societal changes, or changes in exacerbating or remediating factors that make migraine more disabling, among other hypotheses. These issues merit further investigation.
Academic abuse: A conceptual framework of the dimensions of toxic culture in higher education and the impact on the meaning of work
Authors: Coates Tabitha K. L.
Published: May 2024

This article provides a conceptual framework of the dimensions of a toxic culture in higher education and the impact it has on the meaning of work. Seven dimensions of a toxic culture in higher education are presented as follows: toxic leadership; bullying and mobbing; colleagues as enablers; reinforced toxic social norms; purposeful, chaotic change; manipulation of systems, structures and processes; and weaponization of the work itself. The article then discusses how the harmful individual outcomes of working in a toxic culture change the meaning of work from meaningful to meaningless, and the corresponding organizational outcomes. These include high turnover; decreased performance and productivity; lack of effective problem solving; increased expenses for legal, healthcare, unemployment, recruitment and the inability to recruit new talent. Recommendations are provided for systemic culture change.
Joining of Cf/SiC composites using AlCoCrFeNi2.1 eutectic high‐entropy alloy filler by spark plasma sintering
Authors: Wang Rongpei , Wang Gang , Ran Songlin , Wang Wei , Yang Yunlong , Zhao Yu , Gui Kaixuan , He Rujie , Tan Caiwang
Published: May 2024

AlCoCrFeNi2.1 eutectic high‐entropy alloy was introduced to join Cf/SiC composite by spark plasma sintering technique. The influence of holding times on microstructure, shear strength and fracture behavior of the joints was studied. When held for 7 min, the typical microstructure of the Cf/SiC‐AlCoCrFeNi2.1‐Cf/SiC joint was Cf/SiC composite → CrSi2 + FCC + Al8Cr5 + graphite → CrSi2 + FCC + Al8Cr5 → CrSi2 + FCC + Al8Cr5 + graphite → Cf/SiC composite. As the holding time extended, the Ni–Si and Fe–Si brittle phases in the joint gradually reduced, and the diffusion transition layer continued to thicken. The maximum joint strength was 23.9 MPa, which was obtained at 1450°C for 7 min. Analyzed by scanning electron microscopy and energy dispersive spectroscopy, the fracture modes of the joints joined at different holding times were all brittle fracture.
Inclusive multisensory science and immunology books for blind, low‐vision and diverse‐needs audiences
Authors: Favilla Stuart , Tandori Erica , Marshall James
Published: May 2024

This paper presents interdisciplinary research exploring the development of inclusive multisensory science books, communicating immunology data for blind, low‐vision and diverse‐needs audiences. The research adopted an inductive theory‐building approach, practice‐based art methods and music and design methods, leveraging the lived experience of a legally blind artist. The research also involved designers and scientists in a cocreation process, producing books that incorporate tactile artworks, Braille‐inspired protein models, image sonification and interaction. Two multisensory book titles, “The Heroes Within You: A Multisensory Exploration of Infection and Immunity” and “My Goodness: A Multisensory Exploration of Nutrition and Immunity”, were developed for the Monash Sensory Science 2023 Exhibition Day. The books offer an innovative way to make science and art more accessible and engaging, addressing the limitations of traditional museum methods. Feedback from audiences has been positive, emphasizing the fascination, sensory engagement and ease of understanding. This paper highlights the potential for an interdisciplinary and inclusive approach to science and art, demonstrating the value of multisensory books as tools for science communication. The findings highlight the positive reception of this novel approach and suggest its potential for broader applications, promoting inclusivity and accessibility.
Local or regional flaps in developing country: Experience from Eastern Bhutan
Authors: Dorji Kinzang
Published: May 2024

Soft tissue reconstruction plays an integral part in orthopaedic surgery. For developing country like Bhutan, where no micro‐surgical or plastic surgeons are available, orthopaedic surgeons perform the local or regional flaps for the soft tissue defects. In this paper, we describe the use of different kinds of local and regional flaps and its outcome at Eastern Regional Referral Hospital, Bhutan.
The Discursive Struggle for Digital Sovereignty: Security, Economy, Rights and the Cloud Project Gaia‐X
Authors: Adler‐Nissen Rebecca , Eggeling Kristin Anabel
Published: May 2024

This article explores the struggle for ‘digital sovereignty’ in the European Union (EU). A seeming contradiction – the internet, after all, spans the globe – digital sovereignty is portrayed as the winning geoeconomic formula to keep the EU secure, competitive and democratic in the digital future. Approaching digital sovereignty as a discursive claim and analysing it through a case study of the European cloud project Gaia‐X, we show that there is no singular understanding of digital sovereignty in the EU. Instead, we identify six different conceptions across the domains of security, economy and rights. This article outlines three scenarios for how the digital sovereignty agenda may develop and thus shape the EU's digital policy and its relations with the rest of the world: constitutional tolerance (where the conceptions co‐exist), hegemony (where one conception dominates) or collapse (where the agenda falls apart due to inbuilt conceptual contradictions).
A Bayesian approach for exploring person × environment interaction within the environmental sensitivity meta‐framework
Authors: Lionetti Francesca , Calcagnì Antonio , D'Urso Giulio , Spinelli Maria , Fasolo Mirco , Pluess Michael , Pastore Massimiliano
Published: May 2024

Background

For investigating the individual–environment interplay and individual differences in response to environmental exposures as captured by models of environmental sensitivity including Diathesis‐stress, Differential Susceptibility, and Vantage Sensitivity, over the last few years, a series of statistical guidelines have been proposed. However, available solutions suffer of computational problems especially relevant when sample size is not sufficiently large, a common condition in observational and clinical studies.

Method

In the current contribution, we propose a Bayesian solution for estimating interaction parameters via Monte Carlo Markov Chains (MCMC), adapting Widaman et al. (Psychological Methods, 17, 2012, 615) Nonlinear Least Squares (NLS) approach.

Results

Findings from an applied exemplification and a simulation study showed that with relatively big samples both MCMC and NLS estimates converged on the same results. Conversely, MCMC clearly outperformed NLS, resolving estimation problems and providing more accurate estimates, particularly with small samples and greater residual variance.

Conclusions

As the body of research exploring the interplay between individual and environmental variables grows, enabling predictions regarding the form of interaction and the extent of effects, the Bayesian approach could emerge as a feasible and readily applicable solution to numerous computational challenges inherent in existing frequentist methods. This approach holds promise for enhancing the trustworthiness of research outcomes, thereby impacting clinical and applied understanding.
Synthetic long stock and option trading: Evidence from stock splits
Authors: Liu Yifan , Piccotti Louis R.
Published: May 2024

We theoretically and empirically identify synthetic long stock as an alternative driver of option trading. Our model proves that the use of synthetic long stocks by capital‐constrained traders contributes to at‐the‐money (ATM) option trading. Using an event study based on stock splits, we document empirical evidence consistent with the model's predictions. ATM option trading declines after stock splits, and these declines are more pronounced for stock splits with higher stock split factors and for more illiquid stocks but are less pronounced for more illiquid options. Our study implies that option trading can occur even without information or opinion dispersion.
Developmental stasis, sensitivity, and disturbance: Linking concepts to analytic methods using impulsivity and alcohol use
Authors: Hinnant Ben , Jager Justin , Rauer Amy J. , Thompson Morgan J.
Published: May 2024

The goals of this article are to (a) describe and contrast conceptual characteristics of periods of developmental sensitivity, disturbance, and stasis, and (b) translate these concepts to testable analytic models with an example dataset. Although the concept of developmental sensitivity is widely known, the concepts of developmental stasis and disturbance have received less attention. We first define the concepts and their principles and then, using repeated measures data on impulsivity and alcohol use from adolescence to young adulthood, propose the dual latent change score (LCS) growth model as one analytic approach for evaluating evidence for key characteristics of these developmental concepts via examination of intraindividual time‐varying associations.
Present status of scheduled vaccinations and vaccination‐related bleeding in Chinese children with haemophilia
Authors: Li Zhuo , Zhou Yin , Li Kuixing , Zhao Yongqiang , Song Yuqing , Xiao Juan
Published: May 2024

Aim

Many countries have detailed recommendations for haemophilia patients to reduce the risk of vaccination‐related bleeding. However, data from developing countries are lacking. We investigated scheduled vaccinations and vaccination‐related bleeding complications in Chinese children with haemophilia and analysed issues related to vaccinations.

Methods

Children with haemophilia in the PUMCH Haemophilia Treatment Centre were contacted via telephone. We distributed a vaccination questionnaire to their parents. The severity of haemophilia, coagulation factor infusions before vaccination, injection mode, and vaccination‐related complications were analysed.

Results

A total of 440 valid questionnaires were received from 27 of 34 provinces in China. 31.3% (138/440) of the children with haemophilia did not receive all of their vaccinations. Among the children who received vaccinations, 48.1% (197/409) experienced bleeding complications. In patients with severe haemophilia, those on regular prophylaxis had a lower incidence of local hematoma compared to those on intermittent or no prophylaxis (14.3% vs. 26.5% vs. 39.7%, P < 0.05). The incidence of local hematomas was lower by subcutaneous (SQ) injections than by intramuscular injections (24.6% vs. 35.3%, P < 0.05).

Conclusion

The vaccination rate is quite insufficient in Chinese children with haemophilia. Missed vaccinations are related to vaccination‐related bleeding complications. Prophylaxis before vaccination and SQ injections would help reduce bleeding complications.
Genome assembly and annotation of Spilosoma obliqua multicapsid nucleopolyhedrovirus from Bihar hairy caterpillar, an agriculturally important insect pest
Authors: Akram Mohammad , Iquebal Mir Asif , Baptala Kiran Gandhi , Jaiswal Sarika , Gopalakrishnan Kesharivarmen Sujayanand , Kamaal Naimuddin , J Jaisri , Bohra Abhishek , Soren Khelaram , Sachan Deepak Kumar , Husain Raja , Kumar Deepender , Rai Anil , Kumar Dinesh
Published: May 2024

Spilosoma obliqua nucleopolyhedrovirus (SpobNPV) is known as a biocontrol agent against S. obliqua a polyphagous insect. Genome of an isolate designated as SpobMNPV was sequenced and found to have 136,141 bp, 139 putative open reading frames (ORFs) on both sense (48%) and anti‐sense (52%) strands and 97.91% nucleotide similarity with Hyphantria cunea nucleopolyhedrovirus (HycuNPV). All the 38 core genes of baculoviruses were identified and validated in the SpobMNPV genome, which differed from SpobNPV–Manipur isolate in several aspects. In SpobMNPV genome, 7 h were found comprised of 2 to 16 repeated units of 67‐bp at each site with an imperfect 30‐bp palindrome near the centre in both orientations. Comparison of consensus palindrome sequences (hrcons) present in hrs with that of selected alphabaculovirus group I NPVs revealed them to be completely conserved at each side of the hrcons, that is 1‐GxTTTxC‐7 and 22‐TxGxAAAxC‐30. Based on phylogenetic analysis of 38 core genes, SpobMNPV was found closest to the HycuNPV in the group I alphabaculovirus. The complete genome of this isolate is being reported for the first time from North India. The information on genome analysis of SpobMNPV will be an addition to the available database on alphabaculoviruses and also accelerate research on SpobNPV as a component of integrated management of S. obliqua in many economically important crops.
Capsaicin attenuates Porphyromonas gingivalis‐suppressed osteogenesis of periodontal ligament stem cells via regulating mitochondrial function and activating PI3K/AKT/mTOR pathway
Authors: Wang Weijia , Zhou Zhiyan , Ding Tian , Feng Susu , Liu Hongrui , Liu Mengmeng , Ge Shaohua
Published: May 2024

Background and Objective

Prevention of periodontal bone resorption triggered by Porphyromonas gingivalis (P. gingivalis) is crucial for dental stability. Capsaicin, known as the pungent ingredient of chili peppers, can activate key signaling molecules involved in osteogenic process. However, the effect of capsaicin on osteogenesis of periodontal ligament stem cells (PDLSCs) under inflammation remains elusive.

Methods

P. gingivalis culture suspension was added to mimic the inflammatory status after capsaicin pretreatment. The effects of capsaicin on the osteogenesis of PDLSCs, as well as mitochondrial morphology, Ca2+ level, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and osteogenesis‐regulated protein expression levels were analyzed. Furthermore, a mouse experimental periodontitis model was established to evaluate the effect of capsaicin on alveolar bone resorption and the expression of osteogenesis‐related proteins.

Results

Under P. gingivalis stimulation, capsaicin increased osteogenesis of PDLSCs. Not surprisingly, capsaicin rescued the damage to mitochondrial morphology, decreased the concentration of intracellular Ca2+ and ROS, enhanced MMP and activated phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. The in vivo results showed that capsaicin significantly attenuated alveolar bone loss and augmented the expression of bone associated proteins.

Conclusion

Capsaicin increases osteogenesis of PDLSCs under inflammation and reduces alveolar bone resorption in mouse experimental periodontitis.
Low replicability of testing the stress–dominance hypothesis using a trait convergence/divergence pattern
Authors: Pakgohar Naghmeh , Barabás Sándor , Ćuk Mirjana , Csecserits Anikó , Gyalus Adrienn , Lengyel Attila , Lhotsky Barbara , Mártonffy András , Ónodi Gábor , Rédei Tamás , Botta‐Dukát Zoltán
Published: May 2024

Aims

Ecological theories predict that assembly processes are driven by two deterministic forces: environmental filtering and limiting similarity. Their relative importance under different environmental conditions is still not completely obvious. Therefore, in this paper the predictions of the stress–dominance hypothesis (SDH) are tested in several sites.

Location

Kiskunság in Hungary, and Deliblato Sands in Serbia, Central Europe.

Methods

We studied a productivity gradient from open sand grasslands to meadows. The cover of species was estimated visually in plots with a size of 2 m × 2 m, resulting in 344 vegetation plots. Four trait values (height, seed mass, specific leaf area, and leaf size) were collected from field measurements and databases. The weighted median of interspecies distances in traits (a robust alternative to Rao's quadratic entropy) was used to determine functional diversity. The convergence and divergence of each trait in communities were evaluated by randomization tests, and effect sizes were calculated for each plot. We used hierarchical general additive models (HGAM) to determine whether the trend of effect sizes along the productivity gradient is the same in different sites.

Results

The HGAM approach indicated that trait variations follow global trends but are influenced by site‐specific effects. The exception is seed mass, whose variation did not have any trend. Both environmental filtering and limiting similarity exist in the communities, and mainly a shift from trait convergence to a divergence pattern along the productivity gradient was observed.

Conclusion

The results are mainly congruent with theoretical expectations, but the results from the different sites did not lead to the same conclusion. Although traits follow a global trend, the site effect is not negligible. Critical evaluation of SDH using trait convergence/divergence patterns for exploring rules of community assembly points out the weaknesses of this hypothesis. Therefore, alternative ways of studying trait patterns should be found to better understand community organization.
Lenvatinib in hepatocellular carcinoma: Resistance mechanisms and strategies for improved efficacy
Authors: Qin Yongqing , Han Shisong , Yu Yahan , Qi Ding , Ran Mengnan , Yang Mingqi , Liu Yanyan , Li Yunyi , Lu Ligong , Liu Yu , Li Yong
Published: May 2024

Hepatocellular carcinoma (HCC), one of the most prevalent and destructive causes of cancer‐related deaths worldwide, approximately 70% of patients with HCC exhibit advanced disease at diagnosis, limiting the potential for radical treatment. For such patients, lenvatinib, a long‐awaited alternative to sorafenib for first‐line targeted therapy, has become a key treatment. Unfortunately, despite some progress, the prognosis for advanced HCC remains poor because of drug resistance development. However, the molecular mechanisms underlying lenvatinib resistance and ways to relief drug resistance in HCC are largely unknown and lack of systematic summary; thus, this review not only aims to explore factors contributing to lenvatinib resistance in HCC, but more importantly, summary potential methods to conquer or mitigate the resistance. The results suggest that abnormal activation of pathways, drug transport, epigenetics, tumour microenvironment, cancer stem cells, regulated cell death, epithelial–mesenchymal transition, and other mechanisms are involved in the development of lenvatinib resistance in HCC and subsequent HCC progression. To improve the therapeutic outcomes of lenvatinib, inhibiting acquired resistance, combined therapies, and nano‐delivery carriers may be possible approaches.
Survey of hepatitis B virus infection status after 35 years of universal vaccination implementation in Taiwan
Authors: Chang Kai‐Chi , Chang Mei‐Hwei , Chen Huey‐Ling , Cheng Fang‐Wen , Wu Jia‐Feng , Su Wei‐Ju , Hsu Hong‐Yuan , Ni Yen‐Hsuan
Published: May 2024

Background and aims

Hepatitis B virus (HBV) vaccination programs in Taiwan are one of the earliest programs in the world and have largely reduced the prevalence of HBV infection. We aimed to demonstrate the vaccination efficacy after 35 years and identify gaps toward HBV elimination.

Methods

A total of 4717 individuals aged 1–60 years were recruited from four administrative regions based on the proportion of population distribution. Serum levels of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti‐HBs), and hepatitis B core antibody (anti‐HBc) levels were assessed. HBV viral load, genotypes and HBsAg ‘ɑ’ determinant variants were evaluated if indicated.

Results

After 35 years of vaccination, the overall seropositivity rates for HBsAg and anti‐HBc in Taiwan were 4.05% and 21.3%, respectively. The vaccinated birth cohorts exhibited significantly lower seropositivity rates for both markers compared to the unvaccinated birth cohorts (HBsAg: 0.64% vs. 9.78%; anti‐HBc: 2.1% vs. 53.55%, respectively; p < 0.0001). Maternal transmission was identified as the main route of HBV infection in breakthrough cases. Additionally, increased prevalences of genotype C and HBsAg escape mutants were observed.

Conclusion

The 35‐year universal HBV vaccination program effectively reduced the burden of HBV infection, but complete eradication of HBV infection has not yet been achieved. In addition to immunization, comprehensive screening and antiviral therapy for infected individuals, especially for pregnant women, are crucial strategies to eliminate HBV.
Outbreeding reduces survival during metamorphosis in a headwater stream salamander
Authors: Lowe Winsor H. , Addis Brett R. , Cochrane Madaline M.
Published: May 2024

Assessing direct fitness effects of individual genetic diversity is challenging due to the intensive and long‐term data needed to quantify survival and reproduction in the wild. But resolving these effects is necessary to determine how inbreeding and outbreeding influence eco‐evolutionary processes. We used 8 years of capture–recapture data and single nucleotide polymorphism genotypes for 1906 individuals to test for effects of individual heterozygosity on stage‐specific survival probabilities in the salamander Gyrinophilus porphyriticus. The life cycle of G. porphyriticus includes an aquatic larval stage followed by metamorphosis into a semi‐aquatic adult stage. In our study populations, the larval stage lasts 6–10 years, metamorphosis takes several months, and lifespan can reach 20 years. Previous studies showed that metamorphosis is a sensitive life stage, leading us to predict that fitness effects of individual heterozygosity would occur during metamorphosis. Consistent with this prediction, monthly probability of survival during metamorphosis declined with multi‐locus heterozygosity (MLH), from 0.38 at the lowest MLH (0.10) to 0.06 at the highest MLH (0.38), a reduction of 84%. Body condition of larvae also declined significantly with increasing MLH. These relationships were consistent in the three study streams. With evidence of localised inbreeding within streams, these results suggest that outbreeding disrupts adaptations in pre‐metamorphic and metamorphic individuals to environmental gradients along streams, adding to evidence that headwater streams are hotspots of microgeographic adaptation. Our results also underscore the importance of incorporating life history in analyses of the fitness effects of individual genetic diversity and suggest that metamorphosis and similar discrete life stage transitions may be critical periods of viability selection.
Lessons for Israel's Gaza War In America's Strategic Blunders
Authors: Monshipouri Mahmood
Published: May 2024

Lessons learned from counterterrorism operations indicate that purely military solutions are doomed to fail, and Israel is primed to repeat many of these mistakes. The comparison between America's post‐9/11 wars and the Israeli‐Palestinian conflict is not perfect: Al‐Qaeda was in Afghanistan but was not native to the country, and the transnational ISIS emerged out of the chaos in Iraq and Syria. Hamas, by contrast, represents a resistance movement indigenous to Gaza. The militant group is deeply rooted in the political and social struggle for Palestinian self‐determination, and its activities and support are motivated by desperate conditions on the ground. If Israel's assaults on Gaza in retaliation for the October 2023 Hamas bloodbath are to achieve enduring security, key questions arise, including whether the conflict will end with military occupation or political settlement. I argue that Israel should learn from the US strategic blunders in Afghanistan and Iraq. Absent a political solution, Israelis are likely to face terrorist assaults in the future. The military campaign may weaken or impair Hamas's infrastructure and power bases in Gaza, but without a plan for governance and development, Israel is likely to face the re‐emergence of a broadly based resistance movement.
Associations between postoperative cognitive dysfunction, serum interleukin‐6 and postoperative delirium among patients after coronary artery bypass grafting: A mediation analysis
Authors: Zhang Shan , Tao Xiang‐jun , Ding Shu , Feng Xin‐wei , Wu Fang‐qin , Wu Ying
Published: May 2024

Background

POCD is a common complication among patients who underwent coronary artery bypass graft (CABG), it is linked to loss of independence and reduced quality of life.

Aim

To examine the association between postoperative cognitive dysfunction (POCD), postoperative delirium (POD) and interleukin‐6 (IL‐6).

Design

A prospective cohort study.

Methods

Patients who underwent elective isolated CABG were enrolled. POCD was assessed by a set of cognitive function tools. Delirium was assessed using the CAM‐ICU. The logistic regression analyses were used to identify the predictive value of POD or IL‐6 on POCD. The path analysis was used to analyse the relationship among POD, IL‐6 and POCD.

Results

A total of 212 patients were enrolled, with 25.0% of patients developing POD and 32.5% developing POCD. The multiple logistic regression analysis revealed that patients with POD had a four‐fold increased hazard of POCD (OR = 3.655), and patients with IL‐6 ≥ 830.50 pg/mL at the 6th hours after surgery had a 5‐fold increased risk of experiencing POCD (OR = 5.042). However, the mediation effect of POD between IL‐6 and POCD was not statistically significant (β = 0.059, p = .392).

Conclusions

POD and IL‐6 at the 6th hour after surgery (≥830.50 pg/mL) are two potent predictors for POCD, while POD did not play a mediation effect between IL‐6 and POCD.

Relevance to Clinical Practice

Early identification of risk factors (e.g., delirium assessment and testing for serum IL‐6 levels) by clinical nurses for POCD may contribute to the clinical practice for the targeted prevention nursing strategies.
Looking for ALPS: The value of a combined assessment of biochemical markers
Authors: Fernandez Isabel , Touzot Fabien
Published: May 2024

Background

Autoimmune lymphoproliferative syndrome (ALPS) is a rare primary immune disorder caused by defect of the extrinsic apoptotic pathway. The current diagnostic criteria combine clinical features and typical biomarkers but have not been the object of clear international consensus.

Methods

We conducted a retrospective study on pediatric patients who were investigated for autoimmune cytopenia and/or lymphoproliferation at the CHU Sainte‐Justine Hospital over 10 years. Patients were screened using the combination of TCRαβ+ CD4− CD8− “double negative” (DN) T cells and soluble plasmatic FAS ligand (sFASL).

Results

Among the 398 tested patients, the median sFASL and DN T cells were 200 ng/mL and 1.8% of TCRαβ+ T cells, respectively. sFASL was highly correlated with vitamin B12 levels. We identified five patients diagnosed with ALPS for whose sFASL and vitamin B12 levels were the more discriminating biomarkers. While ALPS diagnostic criteria had high sensibility, their predictive value remained low.

Conclusion

sFASL level can efficiently discriminate patients with ALPS when using the appropriate thresholds. Our study highlights the need for an international consensus to redefine the place and threshold of biological biomarkers for ALPS diagnosis.
Post‐vaccine nodules with prurigo in a child successfully treated by dupilumab
Authors: Raison‐Peyron Nadia , El Gana Marwa , Amelot Florence , Bessis Didier
Published: May 2024

We report the case of a 7‐year‐old girl with severe generalized prurigo associated with diffuse persistent pruritic nodules due to sensitization to aluminum‐adsorbed vaccines. Treatment with dupilumab resulted in an excellent therapeutic response.
Inhibition of PbeXTH1 and PbeSEOB1 is required for the Valsa canker resistance contributed by Wall‐associated kinase gene MbWAK1
Authors: Lu Yuan , Mao Xia , Wang Chao , Zheng Yan , Duo Hu , Sun E. , Yu Hongqiang , Chen Zhongjian , Zuo Cunwu
Published: May 2024

Wall‐associated kinases (WAKs) have been determined to recognize pathogenic signals and initiate plant immune responses. However, the roles of the family members in host resistance against Valsa canker, a serious fungal disease of apples and pears, are largely unknown. Here, we identified MbWAK1 in Malus baccata, a resistant germplasm differentially expressed during infection by Valsa mali (Vm). Over‐expression of MbWAK1 enhanced the Valsa canker resistance of apple and pear fruits and ‘Duli‐G03’ (Pyrus betulifolia) suspension cells. A large number of phloem, cell wall, and lipid metabolic process‐related genes were differentially expressed in overexpressed suspension cell lines in response to Valsa pyri (Vp) signals. Among these, the expression of xyloglucan endotransglucosylase/hydrolase (XTH) gene PbeXTH1 and sieve element occlusion B‐like (SEOB) gene PbeSEOB1 were significantly inhibited. Transient expression of PbeXTH1 or PbeSEOB1 compromised the expressional induction of MbWAK1 and the resistance contributed by MbWAK1. In addition, PbeXTH1 and PbeSEOB1 suppressed the immune response induced by MbWAK1. Our results enriched the molecular mechanisms for MbWAK1 against Valsa canker and resistant breeding.
The perceptual model: Emotions as possessed reasons
Authors: Vahid Hamid
Published: May 2024

Emotions play vital roles in our psychology and our lives. They also often form the basis of our evaluative beliefs. On some views, emotions, like perceptions, justify the beliefs to which they give rise. It has, however, been claimed that, unlike perceptions, emotions are merely proxies for the genuine reasons that are constituted by their cognitive bases. In this paper, I argue that this objection arises from the failure to notice the difference between the notions of ‘reasons there are’ and ‘possessed reasons’. After developing an account of what it is to possess a reason, it will be argued that emotions do constitute genuine reasons for the evaluative beliefs that result from them. To support this claim, a distinction is made between thinner and thicker descriptions of the same event, where a thinner description may be in terms of the emotional response, whereas a thicker description may be in terms of possessing a normative reason to hold a belief or to act.
Impact of parity on prepartum activities and behaviour in dromedary camels under farm conditions
Authors: Mansour Nabil , AlKhateeb Rama , Lamghari Fouad
Published: May 2024

This study was conducted to assess the disparities in camel activities such as eating, drinking, sitting, standing, and sleeping between primiparous and multiparous females before parturition using computer vision. Also, any extraordinary behaviours during the final 2 h before parturition and the necessary manual interventions were meticulously recorded. Five primiparous (age: 4.5–7 years) and 7 multiparous (age: 8–14 years; parity: 2.1 ± 1.5) dromedary camels, were included in this study. Pre‐partum females were housed double in a parturition pen provided with two Reolink RLC‐810A cameras and the data were collected and recorded for each female. Two primiparous and 1 multiparous female required assistance in pulling the calf from both forelimbs to complete their parturition (27.3%). The drinking and sleeping activities were similar in primiparous and multiparous females during the recorded 32 h leading up to calving. Only eating activity exhibited a longer period in primiparous females compared to multiparous females specifically during the 12‐h before calving. Sitting activity was longer, and standing activity was shorter in multiparous than in primiparous females during the 24, 12, and 6 h before calving. All parturient camels, whether primiparous or multiparous, exhibited signs of distress. Some extraordinary behaviours were observed, such as two multiparous females attempting to deter their primiparous counterparts from eating. Additionally, three females displayed a distinctive standing position on their knees while their hind limbs were in a complete standing position for 3–5 min before transitioning to sitting or standing positions. Furthermore, one primiparous female stood while the head and forelimbs of the calf partially protruded from her vulva. In conclusion, the application of computer vision and deep learning technology proves valuable for observing prepartum camels under farm conditions, potentially reducing economic losses stemming from delayed human intervention in dystocia cases.
Did the nationwide implementation of electronic fund management in the Indian employment guarantee scheme result in reduced expenditures? A re‐examination of the evidence
Authors: Goel Deepti , Meenakshi J. V. , de Souza Zaeen
Published: May 2024

Digital tools are increasingly being used in welfare programmes to reduce corruption and increase transparency. Banerjee et al. (2020, E‐governance, accountability, and leakage in public programmes: experimental evidence from a financial management reform in India. American Economic Journal: Applied Economics. https://doi.org/10.1257/app.20180302) evaluate the effectiveness of one such intervention. In a later section of their paper, they use a Two‐Way Fixed Effects (TWFE) specification to examine the consequences of the nationwide scale of an electronic funds management system in India's workfare programme, and report that it reduced expenditures by 19%. The present paper extends its analysis by (a) exploiting the recent literature that disaggregates the TWFE coefficient in the presence of staggered treatment timing to pinpoint sources of identifying variation and (b) attempting to uncover heterogeneity in treatment effects. We find that certain problematic comparisons have a large weight in the TWFE coefficient. Further, an event study analysis of the six constituent and valid comparisons shows that there is no support for parallel trends, so lag coefficients cannot be vested with causal interpretation. Our results imply that large‐scale evaluations, because of the very diversity they encompass, need to explicitly account for the factors that are responsible for programme effectiveness.
Do people know how suicidal they will be? Understanding suicidal prospection
Authors: Coppersmith Daniel D. L. , Jaroszewski Adam C. , Gershman Samuel J. , Cha Christine B. , Millner Alexander J. , Fortgang Rebecca G. , Kleiman Evan M. , Nock Matthew K.
Published: May 2024

Introduction

Little research has been done on how people mentally simulate future suicidal thoughts and urges, a process we term suicidal prospection.

Methods

Participants were 94 adults with recent suicidal thoughts. Participants completed a 42‐day real‐time monitoring study and then a follow‐up survey 28 days later. Each night, participants provided predictions for the severity of their suicidal thoughts the next day and ratings of the severity of suicidal thoughts over the past day. We measured three aspects of suicidal prospection: predicted levels of desire to kill self, urge to kill self, and intent to kill self. We generated prediction errors by subtracting participants' predictions of the severity of their suicidal thoughts from their experienced severity.

Results

Participants tended to overestimate (although the average magnitude was small and the modal error was zero) the severity of their future suicidal thoughts. The best fitting models suggested that participants used both their current suicidal thinking and previous predictions of their suicidal thinking to generate predictions of their future suicidal thinking. Finally, the average severity of predicted future suicidal thoughts predicted the number of days participants thought about suicide during the follow‐up period.

Conclusions

This study highlights prospection as a psychological process to better understand suicidal thoughts and behaviors.
Paradoxical and bimodal immune‐mediated dermatological side effects of TNF‐α inhibitors: A comprehensive review
Authors: Behrangi Elham , Moodi Farzan , Jafarzadeh Alireza , Goodarzi Azadeh
Published: May 2024

Introduction

Due to the increasing prevalence of immune‐mediated diseases such as psoriasis, lichen planus, rheumatoid arthritis and inflammatory bowel disease, dermatologists have turned to new biologic drugs known as DMARDs (disease‐modifying anti‐rheumatic drugs) in recent years.

Areas Covered

In this study, we evaluate the immune‐mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer‐reviewed research on the effects of TNF‐α inhibitors in the treatment of skin diseases, as well as adverse effects of these drugs and some of the main causes of these effects.

Expert Opinion

DMARDs are very effective in improving control of the above diseases. TNF‐α inhibitors are an important group of DMARDs that are widely used. The paradoxical adverse events (PAEs) associated with the use of TNF‐α inhibitors are divided into three categories: true paradoxical, borderline paradoxical, and non‐paradoxical. True PAEs include conditions for which TNF‐α inhibitors are approved for treatment. Borderline PAEs are considered to occur with this class of drugs for which there is no definite approval but for which there is sufficient evidence. Although these events are rare, early recognition of the accused drug and appropriate decision‐making may prevent progression of complications and irreversible side effects.
Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications
Authors: Kubo Terufumi , Asano Shiori , Sasaki Kenta , Murata Kenji , Kanaseki Takayuki , Tsukahara Tomohide , Hirohashi Yoshihiko , Torigoe Toshihiko
Published: May 2024

Immunotherapy using immune checkpoint inhibitors (ICIs) has shown superior efficacy compared with conventional chemotherapy in certain cancer types, establishing immunotherapy as the fourth standard treatment alongside surgical intervention, chemotherapy, and radiotherapy. In cancer immunotherapy employing ICIs, CD8‐positive cytotoxic T lymphocytes are recognized as the primary effector cells. For effective clinical outcomes, it is essential that the targeted cancer cells express HLA class I molecules to present antigenic peptides derived from the tumor. However, cancer cells utilize various mechanisms to downregulate or lose HLA class I molecules from their surface, resulting in evasion from immune surveillance. Correlations between prognosis and the integrity of HLA class I molecules expressed by cancer cells have been consistently found across different types of cancer. This paper provides an overview of the regulatory mechanisms of HLA class I molecules and their role in cancer immunotherapy, with a particular emphasis on the significance of utilizing pathological tissues to evaluate HLA class I molecules expressed in cancer cells.
The novel HLA‐B*15:659 allele, identified by Sanger dideoxy nucleotide sequencing in a Chinese individual
Authors: Yang Xi , Xie Zhi‐cong , Ma Li , Xue Han‐chun , Wang Xin‐feng
Published: May 2024

HLA‐B*15:659 differs from HLA‐B*15:02:01:01 by one nucleotide in exon 2.