bluuebunny/crossref_metadata_2025 huggingface dataset:
Soft X-Irradiation Influences the Integrity of Langerhans Cells
Authors: Groh Veronica , Meyer Jürg Ch. , Panizzon Renato , Zortea-Caflisch Claudia
Published: October 2009

This report defines the influence of field soft X-ray irradiation on the integrity of epidermal Langerhans cells (LC) in the guinea pig and mouse systems. Male albino (Rockefeller strain) and piebald F1 (2 ×13 strain) guinea pigs as well as C3H mice (H-2Kk) were exposed to one single shot of different dosages of soft X-rays [80,1,200,1,600, and 3,200 R; 30 kV, 0.5 mm aluminium filter, FSD (focus-skin distance) 12 cm]. 1 and 4 weeks after exposure, skin specimens were taken from the irradiated skin. The demonstration and evaluation of LC was performed basing on their expression of specific histochemical (ATPase) and functional immunologic markers (la antigens). Soft X-irradiation had pronounced effects on number and structure of ATPase- and Ia-antigen-positive cells. In the mouse system, 1 week after exposure to 800 and 1,200 R ATPase-positive cells and, in a more or less parellel manner, Ia-antigen-positive cells () were reduced to 74% (74%) and 70% (68%), respectively, and 4 weeks after exposure to 49% (47%) and 43% (40%), respectively. In the guinea pig system one single shot of 1,600 or 3,200 R produced, respectively, a 35% or a 38% reduction of ATPase-positive cells. Prolonged survival did not result in a further depletion of ATPase-positive cells.
Nailfold Biopsy in Scleroderma and Related Disorders
Authors: Maricq H.R.
Published: October 2009

Nailfold biopsy has been performed in 24 subjects: 15 patients with scleroderma or related disorders and 9 healthy controls. The technique of biopsy is described and the healing of biopsy sites documented by close-up photography. In vivo photomicrographs of the nailfold capillary bed before and after biopsy demonstrate the capillary abnormalities and their evolution in patients during the postbiopsy period.
Reticulate Acropigmentation of Kitamura
Authors: Bajaj A.K. , Gupta S.C.
Published: October 2009

Reticulate acropigmentation of Kitamura has been described in 8 subjects belonging to two unrelated families. All the patients were found to be affected in their second decade.
Measurement of Contractures of the Digits in Systemic Sclerosis
Authors: Serup Jørgen
Published: October 2009

New goniometers were constructed for the measurement of joint motility in the proximal interphalangeal (PIP) and metacarpophalangeal (MP) joints of the digits. 25 patients with systemic sclerosis (mean age 60 years, range 32–83) were studied, and compared with 25 healthy controls, matched for sex and age (mean age 58 years, range 29–87). The flexion, extension and entire joint motility of the PIP and MP joints were significantly decreased. From the measurements in the controls, standards for normal joint motility were defined (mean ± 1 to 2 SD): PIP joint flexion 110°, extension 5°, entire motility 130°; MP joint flexion 90°, extension 20°, entire motility 110°. Joint motility was not correlated to sex and age in these elderly controls. The entire joint motility was reduced in the PIP joint in 19 (76%) patients, and in the MP joint in 17 (68%) patients with systemic sclerosis according to the standards. This corresponded well with the clinical assessment of contracture.
Papillon-Lefèvre Syndrome
Authors: Bravo-Piris J. , Aparicio M. , Moran M. , Armijo M.
Published: October 2009

We report a case of Papillon-Lefèvre syndrome in a patient aged 26 in whom the familial genetic study showed close consanguinity among the parents. Oral treatment with aromatic retinoid during 6 weeks provided nearly total healing of the cutaneous lesions. Among the explorations carried out, attention must be paid to the lessening of chemotactic factors in the blood serum. Throughout his life, the patient suffered pronounced bacterial infectious processes, the last being especially severe and leading rapidly to death.
Porphyria variegata Treated with Cyproterone Acetate and Ethinyl estradiol
Authors: Zachariae H. , Cramers M.
Published: October 2009

The cyclical use of cyproterone acetate and ethinyl estradiol successfully prevented attacks of abdominal pain in a 30-year-old woman suffering from porphyria variegata. Blistering still appeared following light exposure, but possibly to a lesser degree.
An Usual Presentation of Fixed Drug Eruption
Authors: Kanwar A.J. , Majid A. , Singh M. , Malhotra Y.K.
Published: October 2009

A patient exhibited two groups of lesions of fixed drug eruption, one group reacting to hyoscine-N-butyl-bromide and metamizole and the other group to tetracycline. We could not find any report of this kind in the literature.
Generation of Human Inflammation-Resistant Endothelial Progenitor Cells by A20 Gene Transfer
Authors: Liu Jia Wei , Dunoyer-Geindre Sylvie , Blot-Chabaud Marcel , Sabatier Florence , Fish Richard J. , Bounameaux Henri , Dignat-George Françoise , Kruithof Egbert K.O.
Published: October 2009

Inflammatory activation of the vascular endothelium is a major contributory factor to ischemic cardiovascular disease. Endothelial progenitor cells (EPCs) are being investigated for the treatment of ischemic disease or to coat vein grafts for bypass surgery. As an inflammatory environment might reduce their therapeutic efficacy, we sought to generate EPCs that are less sensitive to inflammatory activation. EPCs were obtained from human umbilical cord blood and transduced with a lentiviral vector for stable expression of A20, an anti-inflammatory protein. Nontransduced and green-fluorescent-protein-transduced cells were used as controls. Expression of A20 by EPCs did not modify cell morphology or expression of a panel of 20 proteins known to contribute to angiogenesis. Also, A20 had no effect on the capacity of EPCs to form tube-like structures in Matrigel™. A20 expression reduced EPC activation by tumor necrosis factor-α and interleukin-1β as determined from changes in vascular cell adhesion molecule 1 and E-selectin expression and decreased monocyte transmigration through a monolayer of EPCs. In conclusion, EPCs can be genetically modified to overexpress A20 in a stable fashion. These cells become less sensitive to inflammatory stimuli. This may be of interest in cell-based therapeutic approaches for clinical settings where inflammation is an important pathogenic factor.
Complex Regulation and Function of the Inflammatory Smooth Muscle Cell Phenotype in Atherosclerosis
Authors: Orr Anthony Wayne , Hastings Nicole E. , Blackman Brett R. , Wamhoff Brian R.
Published: October 2009

Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in atherosclerosis and is classically defined as a switch from a ‘contractile’ phenotype to a ‘synthetic’ phenotype, whereby genes that define the contractile SMC phenotype are suppressed and proliferation and/or migratory mechanisms are induced. There is also evidence that SMCs may take on a ‘proinflammatory’ phenotype, whereby SMCs secrete cytokines and express cell adhesion molecules, e.g. IL-8, IL-6, and VCAM-1, respectively, which may functionally regulate monocyte and macrophage adhesion and other processes during atherosclerosis. Factors that drive the inflammatory phenotype are not limited to cytokines but also include hemodynamic forces imposed on the blood vessel wall and intimate interaction of endothelial cells with SMCs, as well as changes in matrix composition in the vessel wall. However, it is critical to recognize that our understanding of the complex interaction of these multiple signal inputs has only recently begun to shed light on mechanisms that regulate the inflammatory SMC phenotype, primarily through models that attempt to recreate this environment ex vivo. The goal of this review is to summarize our current knowledge in this area and identify some of the key unresolved challenges and questions requiring further study.
Evolution of Atopic Dermatitis
Authors: Van Hecke Eric , Leys Greta
Published: October 2009

A follow-up study was done in 50 patients with atopic dermatitis over a time lapse of approximately 20 years. 31 patients (62%) continued to have atopic dermatitis, although usually in a less severe from. Severe atopic dermatitis in childhood, association with asthma and hay fever, presence of atopy in the family seem to indicate that atopic dermatitis will continue in adult age. Hay fever and a familial history of atopy are statistically significant risk factors.
Pterygium inversum unguis et atrophie ponctuée des plis palmaires
Authors: Dupré A. , Christol B. , Bonafé J.L. , Lasserre J.
Published: October 2009

A case is reported with an unusual association: lenticular atrophia of palmar creases (also named hyperkeratosis punctata of palmar creases) and pterygium inversum unguis. A unique pathogenesis could be emphasized.
Contact Allergy as a Therapeutic Tool for Alopecia Areata: Application of Squaric Acid Dibutylester
Authors: Happle R. , Kalveram K.J. , Büchner U. , Echternacht-Happle K. , Göggelmann W. , Summer K.-H.
Published: October 2009

Squaric acid dibutylester (SADBE), a potent contact allergen, was tested for mutagenicity in the bacterial plate incorporation assay (Ames test), in the presence and absence of mammalian microsomes. In contrast to dinitrochlorobenzene which is mutagenic in this test, SADBE was found not to be mutagenic. In 53 patients with extensive or total alopecia areata, SADBE dissolved in acetone was applied weekly to one side of the head, the other side serving as control. In 46 patients (87%), hair regrew either exclusively on the treated side, or considerably faster and denser on this side. In some patients, continuous treatment failed to maintain the response. Persistent response was observed in 37 patients (70%). These results are essentially the same as those obtained with DNCB. Therefore, contact allergy is proposed as a therapeutic concept for alopecia areata.
Pemphigus et pemphigoïde
Authors: Stewart W.M.
Published: October 2009

This comparison of the two diseases – pemphigus and pemphigoid – aimed particularly on points of actual interest. Are thus reviewed: (1) the research on the influence of racial or genetic factors in pemphigus vulgaris; (2) the striking differences between the immunological criteria of the two; (3) the clinical polymorphism of pemphigus: besides pemphigus superficialis, non-bullous forms, usually milder, of various types: herpetiformis, circinate ... are now being described; (4) the importance in all cases of eosinophilic spongiosis; (5) the clinical monomorphism of classical bullous pemphigus; on the contrary, the differences, both from clinical and prognostic points of view, in localized bullous pemphigoid (from the benign mucocutaneous form to the severe scarring disease) and in bullous pemphigoid of children; (6) the cases of genuine pemphigus induced by drugs D-penicillamine, rifampicine) and the problem of the pemphigus-like antibodies; (7) bullous pemphigoid, UV light and practolol; (8) the outstanding association of two major immune diseases, pemphigus vulgaris, myasthenia and thymorna; (9) the mixed bullous dermatoses: pemphigus vulgaris and dermatosis herpetiformis (to separate from herpetiform pemphigus), bullous pemphigoid and dermatosis herpetiformis (bringing up the unsolved problem of mixed or intermediate forms of the two diseases), bullous pemphigoid and pemphigus vulgaris, exceptionally seen, and (10) some news on therapy.
Treatment of Hirsutism, Acne and Alopecia with Cyproterone Acetate
Authors: Ekoe J.M. , Burckhardt P. , Ruedi B.
Published: October 2009

Cyproterone acetate, combined with ethinyl estradiol, was administered to 60 women (mean age: 25 years) suffering from hirsutism, acne and alopecia for 3–39 months. The rate of success was 94% for acne, 85% for hirsutism and 55% for alopecia. These results are comparable to those already reported. No correlation was found between the degree of the disease or plasma levels of testosterone, androstenedione, respectively urinary 17-cetosteroids, and the effectiveness of the treatment. Side effects were rare and identical in frequency and nature to those encountered during treatment with estrogen-containing contraceptives.
La photochimiothérapie orale de l’eczéma atopique
Authors: Sannwald C. , Ortonne J.P. , Thivolet J.
Published: October 2009

11 patients with atopic eczema have been treated using oral photochemotherapy. During the initial phase, complete clearing or more than 80% improvement was obtained in 9 of them. However recurrences occured in most of the patients during maintenance therapy. On the whole, failure were observed in 5 patients and good or very good results in 3 patients. 3 patients discontinued therapy after the initial treatment.
Keratosis follicularis and Familial Benign Chronic Pemphigus in the Same Patient
Authors: Nicolis G. , Tosca A. , Marouli O. , Stratigos J.
Published: October 2009

A case is described with features both of Hailey-Hailey and Darier’s disease in a male patient who presented skin lesions since he was 8 years old. The present case is discussed in relation to data obtained from the literature, and a differential diagnosis from Grover’s disease is made.
Les phycomycoses
Authors: Hocquet P.
Published: October 2009

Phycomycoses are opportunistic fungal diseases as faras mucormycosís is concerned, but for basidiobolomycosis and entomophthoromycosis, the adjective ‘opportunistic’ should be used with caution. Mucormycosis assumes cranial, pulmonary, gastrointestinal, disseminated, cutaneous and focal forms: the infection nearly always develops in a person whose resistance is lowered by a metabolic disorder, a blood dyscrasia, corticosteroid or immunodepressive therapy. It is a frequent complication in leukemia or diabetic acidosis. Basidiobolomycosis and entomophtoromycosis are caused by fungi which belong to the order, Entomophthorales. They are characterized in tissue by broad hyphae which are surrounded by eosinophilic material. These mycoses are treated by potassium iodide.
Association of Pemphigus chronicus with Pregnancy
Authors: Stanoeva Lj. , Konstantinov D. , Vćkova M. , Bitoljanu V.B.
Published: October 2009

The evolution of pemphigus chronicus has been studied in 3 pregnant women. In the first patient, pemphigus vulgaris appeared 2 years prior to pregnancy. In the other 2 patients the disease began during pregnancy. Both women were treated with corticosteroids during their pregnancy which was normal as was delivery. A complete remission was seen in the first case 7 years following corticosteroid therapy, and 8 months after therapy in the second case. Prolonged corticosteroid administration had no adverse effects on the fetus. The occurrence of pemphigus chronicus in the Republic of Macedonia during the past 15 years was only 0.14% of all patients referred to the Department of Dermatology. Female patients with this disease slightly outnumbered males. All forms of pemphigus seen in this period were diagnosed both clinically and histologically. The total number of cases was 53, of which pemphigus vulgaris was 74.4%, pemphigus vegetans 7%, pemphigus foliaceus 9.3% and pemphigus seborrhoicus 9.3%. We present our cases of pemphigus in pregnant women with regard to the fact that only few such cases have been published.
Primo-infection herpétique généralisée de type 2 chez un adulte «Sain»
Authors: Roseeuw D. , Achten G. , de Donder B. , Blondeel A. , Zissis G.
Published: October 2009

A healthy 26-year-old patient presented a primary herpetic type 2 infection. The infection disseminated to the skin, the mucosa and the liver. The clinical course of the infection had a favorable issue.
HLA-Antigens and Psoriasiform Napkin Dermatitis
Authors: Skoven I.G. , Hjortshøj A.
Published: October 2009

HLA typing was performed in 14 patients with psoriasiform napkin dermatitis (PND). Only 2 patients carried one of the three antigens (HLA-B13, B17, Bw37) associated with psoriasis vulgaris. The frequency of these antigens in PND corresponds to that in healthy controls, but differs significantly (p < 0.01) from that in a population of psoriatics. Our results indicate that patients with PND are not true psoriatics, and that PND and psoriasis are different etiological entities.
Introduction aux classifications modernes des lymphomes malins non hodgkiniens
Authors: Heimann R. , van den Heule B.
Published: October 2009

The authors present the historical evolution of the concepts of non-Hodgkin malignant lymphomas which lead to the new functional classifications of Lukes and of Kiel. These classifications are based on the discoveries of modern immunology and are relying on the marking techniques for the identification of the T, B and U lymphocytes. Arguments are presented why these modern nomenclatures should progressively replace the Rappaport classification which preceded the major developments of modern immunology. The Kiel nomenclature is briefly described.
Radiothérapie du mycosis fongoïde
Authors: Regnier R. , Storme G. , Lustman-Maréchal J.
Published: October 2009

The palliative and the curative aspects of radiotherapy in mycosis fungoides are analyzed.
Experience bordelaise du traitement des hématodermies par les electrons accélérés
Authors: Delaunay M.M. , Denepoux R. , Texier L.
Published: October 2009

The autors describe their experience concerning the advantages of palliative and curative electron therapy in mycosis fungoides.
Conclusions
Authors: Achten G.
Published: October 2009

The author tries to conclude on the therapy of the various stages of mycosis fungoides in the light of the recent treatments described during the symposium.
The Effect of Coal Tar Distillate, Cadmium Sulfide, Ichthyol Sodium and Omadine MDS on the Epidermis of the Guinea Pig
Authors: Gloor M. , Dressel M. , Schnyder U.W.
Published: October 2009

In 20 guinea pigs 4 test areas were treated with a standard surfactant vehicle twice weekly for 3 weeks. In another 20 animals the same treatment was carried out with the addition of 1 % cadmium sulfide on one area, of 10% coal tar distillate on another, 2% ichthyol sodium on the 3rd and 1 % Omadine MDS on the 4th. At the end of the test in both animal collectives the number of mitoses in the basal cells of the epidermis (Colcemid method) and the thickness of the epidermis (microscopically) were determined in each of the 4 test areals. All 4 agents lead to a significant inhibition of mitoses compared with the surfactant vehicle. Coal rat also produces an acanthosis. The mitosis inhibition supports the opinion that these agents are suitable for the treatment of dandruff.
Progressive Symmetric Erythrokeratodermia
Authors: Nir Mark , Tanzer Floyd
Published: October 2009

Progressive symmetric erythrokeratodermia is a rare disorder of keratinization manifested by hyperkeratotic plaques on an erythematous base. Familial cases have not been reported. The following is, to our knowledge, the first report of a case from America, as well as the first involving a black child.
Acquired Hypertrichosis lanuginosa
Authors: Ikeya Tazuko , Izumi Akira , Suzuki Mitsuko
Published: October 2009

Acquired hypertrichosis lanuginosa occurred in a man with lung cancer. Fine Ianugo-like hair covered his face, trunk, and extremities, and there were marked pigmentation of oral mucous membrane and a painful red tongue. Our study revealed a high concentration of carcinoembryonic antigen (CEA) in the serum of the patient. We considered that CEA might be an important etiological factor of this disease.
Monilethrix
Authors: Bajaj A.K. , Swarup V. , Gupta S.C. , Shukla S.R. , Pande R.C. , Gupta O.P.
Published: October 2009

A case of monilethrix with an extensive pedigree is being reported. There was associated keratosis pilaris and involvement of eyebrows in addition to the scalp. Argininosuccinic acid was absent in the urine.
Communication La N-isopropyl-N′-phénylparaphénylènediamine a-t-elle sa place dans la batterie standard d’allergènes? Importance de cet allergène dans I’intolérance au caoutchouc
Authors: Foussereau J. , Cavelier C.
Published: October 2009

Allergic contact dermatitis to N-isopropyl-N′-phenylparaphenylenediamine (IPPD) from rubber is far from being exceptional. Out of a total of 56 cases of allergic contact dermatitis to IPPD, 42 were considered as caused by occupational contacts: 17 cases were found in tyre manufacturers, 9 in car-mechanics, 9 in drivers, and 7 in various industrial branches. Out of the 56 cases, 23 also reacted allergically to mercaptobenzothiazole or to tetramethylthiuramdisulphide, or to both of these substances. In a chromatographic analysis of samples of 9 different tyre brands, IPPD was found in 8 cases.
A Case of Early Haemachromatosis without Diabetes
Authors: Okrasinski Henryk
Published: October 2009

The author presents a case of early haemachromatosis with skin changes, endocrinological disturbances, circulatory symptom and upsets of the alimentary tract treated by blood letting with good results.
Eccrine Angiomatous Hamartoma: a Rare Skin Lesion with Diverse Histological Features
Authors: Challa Venkata R. , Jona Juda
Published: October 2009

A case of painful eccrine angiomatous hamartoma of the wrist in a 10-year-old girl is presented. It was located in the reticular dermis and contained abnormal tubules resembling eccrine secretory coils and thin vascular channels dispersed in the collagenous tissue of the dermis. Some eccrine ducts showed dilatation. The noteworthy features of this case were the absence of hyperhidrosis over the lesion, and the presence of focal neural infiltration by the tubular structures. Electron microscopy showed mostly clear cells and occasional dark cells lining the tubular structures. This case supports the theory of abnormal induction of heterotypic dependency with resultant malformation of adnexal as well as mesenchymal elements.
Eine operative Therapie der Hyperhidrosis axillaris
Authors: Elchmann A. , Ott F. , Scherrer A.
Published: October 2009

Development and problems connected with the surgical treatment of hyperhidrosis are considered. 32 patients were operated according to the method of Préaux. The results are good, both cosmetically and with regard to the diminution of the excessive sweat production.
Essai du milieu de culture «Microcult GC» pour le dépistage des gonococcies
Authors: Olmos L. , Bergues J.P. , Ellena V. , Vienot M. , Laugier P.
Published: October 2009

A trial of the culture medium ‘Microcult GC’ for the detection of gonorrhea in 246 patients confirms its utility. The direct smear of the exudate is still indispensable. The best culture medium is the Thayer-Martin plate. The main advantage of the new medium tested is its simple utilization technique which makes it suitable for the practitioner.
Die Strahlentherapie von Präkanzerosen und Karzinomen des Kopfes
Authors: Schwarz K.
Published: October 2009

On the basis of results and check-ups gained at the clinic of Zurich, it can be demonstrated, once more, that radiotherapy of precancerous lesions and tumors, even critically considered, is still a very valuable and safe method of treatment with lasting success in 90 to 99% of the cases. At the same time this method safeguards the essential functions, even in the case of particularly difficult areas.
Ultrastructure of Macrophage-Lymphocyte Interaction in Purpura pigmentosa progressiva
Authors: Klug H. , Haustein U.-F.
Published: October 2009

Thin sections of pathologically changed skin lesions of patients suffering from purpura pigmentosa progressiva, a disorder which seems to be mediated by delayed type of allergy, were electron microscopically investigated. In 5 of the 7 cases we found cell infiltrates of the dermis consisting of many lymphocytes frequently in apposition to macrophages (histiocytes). The cell interactions observed occurred either by microvilli-like cytoplasmic protuberances or by local areas of the plasma membrane apposition. No submicroscopical alterations of the cytoplasm were found in the interacting cells although numerous macrophages show abundant microfilaments. The findings observed are interpreted as the ultrastructural substrate of cell cooperation for presenting and transfering antigens from macrophages to T lymphocytes. However, the question concerning the mechanism of the transfer remains open.
Clear Cell Hidradenocarcinoma
Authors: Hernández-Pérez E. , Cruz F.A.
Published: October 2009

A clear cell hidradenocarcinoma occurred in a 15-month-old child. The tumor, present from birth, recurred after two excisions and brought on metastasis to the skin, lymph nodes and lungs. Histologically, there was no evidence of malignancy, not even in the metastasis.
Photo-Onycholysis Induced by 8-Methoxypsoralen
Authors: Zala L. , Omar A. , Krebs A.
Published: October 2009

Two patients, whom we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation of numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.
Virus-Like Structures in the Skin in the Course of Chronic Lupus Erythematosus
Authors: Wrzolkowa Teresa , Kozakiewicz J.
Published: October 2009

Six skin biopsies of one patient, from foci of chronic lupus erythematosus in different stages of development of the disease and from unchanged skin were examined by electron microscope. The aim of the investigations performed was to check the presence of reticulotubular structures in these samples. Reticulotubular structures appeared in numerous quantities in early foci, while in scarred foci, as in structurally unchanged skin, they were, although always present, rare.
Aspects of Lymphocyte Function in Behçet’s Disease
Authors: Haim S. , Mekori T. , Sobel J.D. , Robinson E.
Published: October 2009

Aspects of lymphocyte function were investigated, in vitro, in nine patients with active Behçet’s disease. The rosette formation technique revealed a slight decrease in number of T lymphocytes and more so of B lymphocytes. In spite of their low number, the transformation of the T lymphocytes in response to mitogens did not show a significant difference from that of normal controls. This may indicate a hyperreactivity, and in two instances a spontaneous blastogenesis prior to addition of mitogens, was also noted. The immunoglobulins and complement levels in serum were within normal limits.
Pyoderma gangrenosum in Immunosuppressed Patients
Authors: Haim S. , Friedman-Birnbaum R.F.
Published: October 2009

Two cases with pyoderma gangrenosum are presented. The course, in both cases, suggested that immunosuppressive therapy may play an etiological role in the disease. The first was a kidney recipient receiving prednisone and azathioprine and the second, a patient with pemphigus vulgaris who was treated with prednisone and methotrexate.
Chromosomal Breakage in Systemic Sclerosis and Related Disorders
Authors: Emerit Ingrid
Published: October 2009

Chromosome aberrations such as gaps and breaks of one or both chromatids, acentric fragments, dicentrics, ring chromosomes and other abnormal chromosomes are observed in lymphocyte and fibroblast cultures as well as in direct bone marrow preparations from patients with systemic sclerosis. A serum factor producing chromosome breaks in mitoses from healthy donors was observed in 37 of 42 scleroderma patients. The biochemical nature of this breakage factor is still undefined. Increased breakage is also noted in a high percentage of healthy family members of scleroderma patients. It is also a common feature of related disorders such as lupus erythematosus, dermatomyositis, periarteritis nodosa and rheumatoid arthritis. An increase in chromosome breaks and rearrangements is also present in NZB mice developing spontaneously an autoimmune disorder that has been extensively studied by workers interested in lupus erythematosus. The similarity of the cytogenetic findings provides the opportunity to use these mice as an experimental model to investigate relationships between immunological perturbations and chromosomal aberrations.
Treatment of Acne vulgaris with the Retinoic Acid Derivative Ro 11-1430
Authors: Christiansen Jørgen , Holm Per , Reymann Flemming
Published: October 2009

In a double-blind, randomized, group-comparative clinical trial, 31 patients with acne vulgaris received topical treatment for 6-8 weeks with a lotion containing either 0.05% retinoic acid or 0.1 % of the retinoic acid derivative Ro 11-1430. The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid. The treatments appeared to be approximately equally effective in reducing the number of acne elements, but due to the limited number of patients studied, the trial was admittedly not sufficient to detect differences with regard to therapeutic efficacy.
Pyoderma gangrenosum with Koebner Effect and Mondor’s Disease in the Same Patient
Authors: Odeh F.
Published: October 2009

Case description: a 34-year-old female with the constellation of bullous pyoderma gangrenosum, Mondor’s disease, Koebner phenomenon and pleuropneumonia. Steroid therapy was successful.
Generalized Granuloma anulare in a 15-Month-Old Infant
Authors: Takigawa Masahiro , Aoshima Tadahiro
Published: October 2009

A Japanese girl aged 15 months had an eruption of 3 months’ duration on the face, trunk, and extremities except for the palms and soles. The lesions were infiltrated papules varying from 2 to 3 mm in diameter. Blood eosinophilia of 5% was demonstrated. Skin biopsy specimen revealed a necrobiotic palisading granuloma in the corium. All lesions began to subside after 1 weeks’ administration of oral corticosteroid and completely involuted in 2 months. A possible etiologic role of insect bites was considered.
Zelluläre Immunphänomene bei der Sklerodermie
Authors: Fritz J. , Sandhofer M.
Published: October 2009

The leucocyte-migration-inhibition test was performed to examine 10 patients with progressive systemic sclerosis and 6 patients with linear scleroderma for evidence of cell-mediated immunity to RNA, DNA, human muscle antigen and collagen human type I. An inhibition of cell migration was detected in 6 patients with progressive systemic sclerosis (PSS) and in 3 patients with linear scleroderma in presence of RNA. No cellular reactivity in presence of DNA was observed. Seven cases with PSS, and all 6 cases with linear scleroderma showed a migration inhibition when human muscle antigen was tested. Cell-mediated immunity to collagen human type I was discovered 7 times in PSS and 2 times in linear scleroderma.
Communications Diagnostic Criteria in Dermatitis Herpetiformis
Authors: Kint A. , Geerts M.L. , de Brauwere D.
Published: October 2009

The diagnostic criteria for dermatitis herpetiformis are reviewed in 14 patients. The most faithful ones were the presence of intrapapillary microabscesses in the vicinity of the blister and the presence of IgA. The intestinal biopsy was more often normal than pathologic.
Pityriasis rubra pilaris
Authors: Niemi Kirsti-Maria , Kousa Merja , Storgårds Karin , Karvonen Jaakko
Published: October 2009

In a clinical study, 27 of 31 cases of pityriasis rubra pilaris (PRP) had two or more of the following clinical features: erythroderma, well-confined healthy islands inside the inflammatory areas, keratoderma of the palms and soles, or visible follicular hyperkeratosis. Histological features were: perifollicular parakeratosis in 26 cases, hyper-keratosis in 27 cases; the number of granular layers varied greatly from case to case and within one specimen; acanthosis was eczematous in 20 cases and psoriasiform in 8 cases. Erythroderma in PRP in this study was self-healing, lasting 2–6 months with one exception, but PRP must as a whole be considered a mild, chronic disease lasting on average 5.7 years. Complete recovery occurred in only 8 patients and 5 of these had had an erythro-dermic onset. Serum vitamin A level and tolerance test were normal. No immunological aberrations could be found. The HLA phenotype frequencies in PRP patients did not differ significantly from those in a Finnish control population. The autoradiographic study of the epidermal cells showed an increase in the cell production in the epidermis.
Formationsmuster des Hautepithels bei Mensch und Meerschweinchen
Authors: Weirich Erich G. , Rufli Theo , Longauer Josef K.
Published: October 2009

Comparative histometry of human and guinea-pig epidermis revealed that in the latter development of the (subcorneal) superficial epithelium is significantly less, and that of the (mostly follicular) deep epithelium is markedly more pronounced than in man.
Pemphigus-Like Antibodies in Dermatitis herpetiformis
Authors: Ikai K. , Imamura S.
Published: October 2009

Pemphigus-like antibodies were demonstrated in a patient with dermatitis herpetiformis. The patient was a 28-year-old Japanese who showed itchy tense bullae on the back, chest and shoulders. We speculate the antibodies are similar to those found in burns, drug eruptions and certain other skin diseases.
Warty Hyperkeratoses, Cellular Immune Defect, and Tapetoretinal Degeneration in Poikiloderma Congenitale
Authors: Haneke E. , Gutschmidt E.
Published: October 2009

Report of a 13-year-old girl suffering from poikiloderma congenitale with warty hyperkeratoses, increased susceptibility to infections and tapetoretinal degeneration. The diminished PHA lymphocyte stimulation is an indicator of an immune cellular defect which is probably the cause of the frequent infections. The significance of keratotic lesions with regard to possible cancer development in later life is discussed.
Lichen purpuricus
Authors: der Zwan Verburgh-van , Manuel H.R.
Published: October 2009

A young man aged 17 developed, on the left thigh, in the course of 2 years an eruption corresponding macroscopically as well as microscopically to the diagnosis lichen purpuricus. A description of this patient and a review of the scarce literature on the subject is given.
Horizontal Distribution of Three Dehydrogenases in the Cow Snout Epidermis
Authors: Cotton D.W.K. , Janzing-Pastors M.H.D. , Jonckheer-Vanneste M.M.H.
Published: October 2009

A technique is described for quantifying enzyme activities in the various layers of the epidermis of the cow snout. Values for glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and lactate dehydrogenase are reported. In general, the amount of each enzyme is largest in the basal layers and diminished towards the stratum corneum. The exception was G6PD whose highest peak of activity was in the region of the stratum spinosum.
Skin Porphyrin and Photosensitivity in the Porphyric Rat
Authors: Miura T. , Magnus I.A. , Jones K. , Doyle M.
Published: October 2009

Skin porphyrin assays and photobiological studies in normal and porphyric rats suggest that in the latter, skin photosensitivity to 400 nm radiation is associated with raised uroporphyrin and 7-carboxylic porphyrin in the skin.
Ultrastructural Response of Epidermis to Actinomycin D
Authors: de Rey B.M. , Cabrini R.L.
Published: October 2009

The response of the epidermis to the effects of actinomycin D was analyzed at ultrastructural level. Important cellular alterations were found at 40 h post injectionem. The degree of nucleolar segregation varied depending on the epidermal layer assayed. Analogies and departures between the present findings and previous investigations, on a similar model with X-ray irradiation, are discussed.
Evaluation des corticostéroïdes topiques
Authors: Durocher Louis-Philippe , Bielmann Pierre
Published: October 2009

In the blanching test, placebo, basis and active topical steroid should always be used together and at the experimental sites randomized. The semi-quantitative measure (ordinal scale) of the effects induced by topical steroid does not seem to be more accurate than the qualitative measure (nominal scale). In an attempt to introduce an objective measurement of the blanching effect based on the temperature variation, no correlation has been found between cutaneous temperature and blanching effect. However, some thermal constants have been established on the forearm which is often used in experimental dermatology.
A Case of Acute Promyelocytic Leukaemia with Bullous, Haemorrhagic and Necrotic Skin Lesions
Authors: Bernengo M.G. , Leigheb G. , Zina G.
Published: October 2009

Erythematous-oedematous-bullous skin lesions with necrotic vegetating and haemorrhagic evolution evocating atypical pemphigus or bullous reticulosis, revealed acute promyelocytic leukaemia. Histologically, vesicles and bullae were observed in the Malpighian layer and a dense infiltrate with atypical blasts in the dermis. Atypical promyelocytes (22%) were found in the bone marrow. The cytochemical features of promyelocytes, haemorrhage due to disseminated intravascular coagulation supported the diagnosis.
Dermatopharmacology of Salicylic Acid
Authors: Weirich Erich G. , Longauer Josef K. , Kirkwood Alan H.
Published: October 2009

The influence of salicylic acid on pathological epithelial proliferation has been evaluated by means of the epidermal hyperplasia inhibition test in the guinea pig. 3% w/w salicylic acid dissolved in ethanol reduced surface epithelial hyperplasia by 15%, i.e. exhibited activity comparable to that of hydrocortisone 0.1% w/w. 1% w/w salicylic acid dissolved in a dimethylacetamide-acetone-ethanol mixture exerted an even greater degree of antihyperplastic activity on the surface epithelium (––18%) and also a marked inhibitory effect on deep epithelial proliferation (––10%).
Leiomyosarcoma of the Labium majus with Extensive Metastases
Authors: Pandhi R.K. , Bedi T.R. , Dhawan I.K.
Published: October 2009

A rare case of leiomyosarcoma of the labium majus is reported. An early and rapid hematogenous spread to other viscera proved fatal within 2 months of its onset.
Tritiated Thymidine Uptake in Pig Skin
Authors: Jurnovoy Joel B. , Forbes Donald , Johnson Waine C.
Published: October 2009

Tritiated thymidine (3HT) was used in one of three ways to label deoxyribonucleic acid replication in epidermal cells of miniature swine: (1) the radioactive material was injected intracutaneously in vivo; (2) the radioactive material was injected intracutaneously into biopsy specimens and the specimens incubated in vitro in Eagle’s medium, or (3) uninjected biopsy specimens were incubated in Eagle’s medium with added 3HT. The first two methods yielded the same proportions of labeled cells with uniform distribution of labeled cells. The third method resulted in labeling of cells mainly at the periphery of the biopsy specimens. The advantages of the in vitro over the in vivo technique of injection of 3HT includes the fact that injecting a biopsy specimen avoids the problems of large amounts of radioactive waste disposal in animal studies or the legal and ethical problems of tracer studies in humans.
‘Isopathic Phenomenon’ in Leprosy
Authors: Rao B.N. , Satyanarayana B.V. , Venkatarathnam G. , Reddy C.R.R.M.
Published: October 2009

Isopathic phenomenon of Sagher was elicited in 21 proved leprosy patients (consisting of 7 lepromatous, 7 tuberculoid, 3 neuritic, 2 borderline, and 2 indeterminate types). The substances used to elicit the isopathic phenomenon were BCG lepromin, Indian ink and staphylococcal vaccine. Isopathic phenomenon was elicited in most of the cases and BCG was the substance which produced the most responses.The phenomenon could be used to classify difficult cases of leprosy.
Influence of Ultraviolet Light, Various Temperatures, and Zinc Ions on Anthralin (Dithranol)
Authors: Raab Wolfgang P. , Gmeiner Bernhard M.
Published: October 2009

The changes of anthralin under various physical conditions (temperature, ultraviolet irradiation) were investigated by biochemical assay (inhibition of G-6-PDH activity), by oxygen monitor (increased oxygen consumption in the presence of zinc ions), and by recording the absorption spectra. Higher temperatures and exposure to ultraviolet light provoke the formation of a biochemically highly active compound within short periods of time. In clinical therapy, this compound may easily be formed when anthralin is used together with ultraviolet irradiation (Ingram method). Changes in the biochemical activity of anthralin are accompanied by changes in the absorption spectra. Oxidation (e.g. in the presence of zins ions) or inhibition of oxidation (e.g. in the presence of salicylic acid) may easily be detected by spectroscopic assay.
Basal Cell Carcinoma in Children
Authors: Hernández-Pérez Enrique
Published: October 2009

Basal cell carcinoma in children is rare. Two cases are reported and the pertinent literature is reviewed. The facts that apparently separate them from those pertaining to the nevoid basal cell carcinoma syndrome are discussed.
Treatment of Psoriasis with Long-Wave Ultraviolet Light
Authors: Young E. , van der Leun J.C.
Published: October 2009

The effect of long-wave ultraviolet light on psoriasis was studied in 10 patients, using the method of paired comparisons. The radiation failed to have any demonstrable effect.
Topographische Unterschiede in der Ausbildung und Reaktivität der Aurikulartalgdrüsen des Kaninchens
Authors: Weirich Erich , Longauer Josef
Published: October 2009

The size and development of the sebaceous glands lining the inner and outer surfaces of the ear were compared in intact rabbits, castrated juvenile rabbits, and castrates subsequently treated with relatively high doses of a depot androgen preparation (Triolandren®). It was found that the glands in the inner surface skin reacted much more strongly than those in the outer surface, especially in the androgen-treated castrates. Only slight differences in reactivity were found in the untreated castrates, and the controls showed no clear-cut differences at all.
Determination of Oxyquinoline Concentrations in Plasma in a Patient Treated for Acrodermatitis enteropathica – an Aid in Therapeutic Control
Authors: Hägermark Ö. , Wahlberg J.E. , Germanis M.
Published: October 2009

Halogenated oxyquinolines have a pronounced therapeutic effect in acrodermatitis enteropathica. Since 1966, however, ocular and neurological side effects have been reported at the high doses required to obtain a clinical effect. We describe a patient in whom we followed the concentration of chlorquinaldol (5,7-dichloro-8-hydroxy-2-methylquinoline, Sterosan®) in plasma. The improvement in the skin condition was related to the dose; at a plasma concentration of 0.8–1.1 mg% the status was satisfactory. The half-life after ingestion of 300 mg Sterosan was calculated to be about 7 h. At a dosage of 300 mg every 8th hour a steady-state level of around 0.8-1 mg% was attained. We do not know the relationship between plasma levels and therapeutic and toxic effects. An answer to this question could be obtained by following up several cases on long-term treatment.
Comparative Studies of Rubella Antibodies in Psoriatic Patients Treated with Methotrexate
Authors: Remy Wolfgang , Bockendahl Hans , Antoniadis Grigorios
Published: October 2009

Rubella antibody titers were measured in psoriatic patients using the HAH test. Some patients received immuno-suppressive therapy while others did not. The difference between antibody titers in both groups was not significant. Antibody titers in patients with verified rubella did not change after a booster vaccination. These results are discussed in view of Epstein’s assumption of an immunologic block in psoriatic patients. At least, the comparative study of titers in psoriatic patients and healthy subjects does not suggest an impairment in rubella antibody synthesis.
Topical Vitamin A Acid (Airol®) and Systemic Oxytetracycline in the Treatment of Acne Vulgaris
Authors: Christiansen Jørgen V. , Gadborg Ejnar , Ludvigsen Knud , Konstmann Meier Carl H. , Nørholm Asger , Osmundsen P.E. , Pedersen Daniel , Rasmussen Kaj A. , Reiter Henry , Reymann Flemming , Rosman Niels , Sylvest Bent , Unna Paul , Wehnert Robert , Aastrup Bent , Andersen Bjørn , Holm Per
Published: October 2009

A double-blind, controlled multi-centre trial with 238 patients was employed to study the relative merits of three treatment schedules in acne vulgaris. Schedule A consisted of oral oxytetracycline and topical vitamin A acid cream (0.05%), schedule B of oral oxytetracycline alone, and schedule C of vitamin A acid alone. Large and statistically significant reductions occurred in the number of come dones, papules and pustules during 8 weeks of therapy, which could be attributed neitherto placebo effects nor to natural history of the disease.
Macrophagic Pigment Spread in Benign Cellular Nevi
Authors: Mehregan Amir H.
Published: October 2009

Extensive macrophagic pigmentation may occur in benign cellular nevi extending deep into the corium or spreading peripherally to give the clinical impression of a blue nevus or a malignant melanoma. Eight examples of this type are reported.
Ichthyosis linearis circumflexa Comèl
Authors: Mevorah B. , Frenk E. , Brooke Eileen M.
Published: October 2009

A clinico-statistical analysis of cases with ichthyosis linearis circumflexa and Netherton’s syndrome is presented. It is suggested that ichthyosis linearis circumflexa with trichorrhexis invaginata, Netherton’s syndrome, and ichthyosis linearis circumflexa without hair changes should be regarded as close variants of the same disease process.
Anti-γ-Globulin Factors in Psoriasis
Authors: Florin-Christensen Alejo , Cocco José A. Maldonado , Arana Roberto , Porrini Ana , Mom Arturo , Morteo Osvaldo García
Published: October 2009

55 psoriatic patients (including 15 with psoriatic arthritis) and 50 healthy individuals ‘seronegative’ according to standard procedures were investigated employing an immunoadsorption technique. Antiglobulins were only found in psoriatic sera (18.5%). Clinical correlations and current etiopathogenetic hypotheses are discussed.
Detection of a Non-Dialysable Permeability-Increasing Substance in the Human Plasma and Blister Fluid
Authors: Bajaj A.K. , Pasricha J.S. , Bhide N.K. , Kandhari K.C.
Published: October 2009

A non-dialysable substance capable of increasing the permeability of cutaneous capillaries was detected in 25 out of 29 blister fluids, all the 28 plasma samples of patients with vesiculobullous disorders and 19 out of 20 plasma samples of normal controls. This substance was stable at ––10°C for at least 11 days, but was inactivated by heating at 100°C for 1 h. It had no effect on the isolated guinea pig ileum. The activity in the plasma of contact dermatitis patients was statistically higher than the normal controls.
Preliminary Report on the Treatment of Recurrent Herpes simplex with Poliomyelitis Vaccine (Sabin’s)
Authors: Tager Adolph
Published: October 2009

Twenty-three patients with recurrent Herpes simplex have been treated over a period of 4 years (1969–1972) with poliomyelitis vaccine (Sabin’s), given perorally in the dose of 4 drops once a month for 3 months only. In 74% of cases, this treatment resulted in full recovery with no relapse over a follow-up period of 1–4 years. No harmful side-effects whatsoever were noticed in any of the patients. On the basis of these results, it is concluded that the peroral administration of Sabin’s vaccine is a simple, safe and extremely effective method of treating recurrent Herpes simplex infection.
Etude des cellules cornées du psoriasis en microscopie électronique à balayage
Authors: Barrière H. , Litoux P. , Géraut C.
Published: October 2009

The scanning electron microscope makes it possible to study the horny cells surface, with a very high magnification. In psoriasis, several abnormalities have been previously noticed, among which the presence of microvilli (or granulations) on the horny cells surface. Those microvilli have a diameter of 0.4 millimicr. and are grossly round shaped. On the same cells, or on other ones, holes or pores can be found. Some authors consider these formations as characteristics of psoriasis. According to them, they represent the desmosomes and may be a sign of the immaturity of psoriasic horny cells. In fact, these cells can be found in other diseases of the horny layer, and also on a normal skin. On the contrary, their shape may be more characteristic of the psoriasis. In this disease they seem smaller, more irregular and above all more sparse, and they clearly let appear the cell surface among them.