bluuebunny/crossref_metadata_2025 huggingface dataset:
SIGNATURE-DRIVEN REPURPOSING OF MIDOSTAURIN FOR COMBINATION WITH MEK1/2 AND KRASG12C INHIBITORS IN LUNG CANCER
Authors: Vicent Silve , Macaya Irati , Román Marta , Welch Connor , Entrialgo-Cadierno Rodrigo , Salmón Marina , Santos Alba , Feliu Iker , Kovalski Joanna , Lopez Ines , Rodriguez-Remirez Maria , Palomino-Echeverria Sara , Lonfgren Shane , Ferrero Macarena , Calabuig Silvia , Ludwig Iziar , Lara-Astiaso David , Jantus-Lewintre Eloisa , Guruceaga Elizabeth , Ponz-Sarvise Mariano , Pineda Antonio , Lecanda Fernando , Ruggero Davide , Khatri Purvesh , Santamaría Enrique , Fernández-Irigoyen Joaquín , Sanchez Irene Ferrer , Paz-Ares Luis , Drosten Matthias , Barbacid Mariano , Gil-bazo Ignacio , Narayanan Shruthi
Published: June 2023

Resistance mechanisms compromise response to single targeted therapies, favoring the idea that combinatorial strategies are key to circumvent this clinical problem. Combinatorial strategies for cancers driven by oncogenic KRAS based on MEK1/2 or KRASG12C inhibitors have so far incorporated abrogation of KRAS proximal effectors involved in oncogenesis or treatment resistance. However, the antitumor effect is highly determined by compensatory mechanisms specifically arising in certain cell types or tumor subgroups. A potential strategy to find drug combinations spanning a large percentage of mutant KRAS lung cancers may capitalize on the common, distal gene expression output elicited by oncogenic KRAS. Here, integrating a signature-driven drug repurposing approach and a pairwise pharmacological screen, we identify a synergistic drug combination consisting of multityrosine kinase PKC and MEK1/2 inhibitors. The drug combination functions in a genotype specific manner, elicits a cytotoxic response both in vitro and in vivo models, and in part involves inhibition of AURKB. Furthermore, we show that the KRASG12C inhibitor Sotorasib can replace the MEK inhibitor with similar cellular and molecular results, including antitumor effect in a genetically engineered mouse model of lung cancer driven by KRasG12C. Proteome profiling links dysregulation of MYC expression to the effect of PKC inhibitor-based drug combinations. Furthermore, we demonstrate that MYC overexpression functions as a resistance mechanism to MEK1/2 and KRASG12C inhibitors. Our study provides a rational framework to nominate drugs entering combinatorial strategies and unveils novel MEK1/2- and KRASG12C-based therapies for lung cancer.
Changes in Spectrum of Respiratory Pathogen Infections and Disease Severity Among Children in Hohhot: Impact of COVID-19 Prevention Measures
Authors: Gan Yan-Zi , Yang Peng , Liu Rui , Wang Yan-Hai , Hu Yu-Wei , Yang Yang
Published: June 2023

Background Acute respiratory infections (ARIs) are caused by various pathogens, and the outbreak of the novel coronavirus has led to changes in the patterns of respiratory pathogen infections. Through long-term study of respiratory tract infection data in children from Hohhot, significant differences in the spectrum of respiratory pathogen infections, disease severity, and seasonal patterns have been discovered between 2022 and 2023. Methods Throat swabs were collected from 605 children with ARIs at the First Hospital of Hohhot, and pathogen detection was performed using microarray technology. Blood biomarkers, symptoms, and clinical diagnoses were evaluated. Results The study found that 56.03% of the patients were male, with an average age of 3.45 years. Pathogen dynamics revealed that SARS-CoV-2 was the most prevalent infection, accounting for 262 cases. It persisted from October 2022 to January 2023 and then disappeared. Influenza A virus (IAV) cases peaked in March 2023. Respiratory syncytial virus (RSV), Influenza B virus (IBV), Parainfluenza virus (PIV),Mycoplasma pneumoniae(M. pneumoniae),Escherichia coli(E. coli), Staphylococcus aureus (S. aureus), andGroup A streptococcus(GAS) were not detected after December 2022. The proportion of mixed infections was 41.94% among SARS-CoV-2 patients, while other pathogens had mixed infection rates exceeding 57.14%. Before December 2022, the mean value of white blood cell (WBC) count forStreptococcus pneumoniae(S. pneumoniae),Haemophilus influenzae(H. influenzae), Epstein-Barr virus (EBV), and Cytomegalovirus (CMV) was 8.83*10^9/L, C-reactive protein (CRP) was 18.36 mg/L, and procalcitonin (PCT) was 1.11 ng /ml. After December 2022, these values decreased to 5.5*10^9/L, 6.33 mg/L, and 0.24 ng /ml, respectively. Similarly, the proportion of patients with cough, difficulty breathing, and running nose, as well as the diagnosis of lower respiratory tract infections, decreased in December 2022. However, the situation was different for SARS-CoV-2 infections. Conclusions Strict SARS-CoV-2 policies reduced the infection risk forS. pneumoniae,H. influenzae, EBV, and other pathogens before November 2022. However, patient symptoms worsened compared to after November 2022, possibly due to an excessive focus on SARS-CoV-2, neglecting other diseases, and reduced population immunity to respiratory infections.
Ethanolic extract of Moringa oleifera leaves shows Anti-hyperglycemic potencies on experimental Wistar rats: a focus on optimization of biomarkers of type 2 diabetes
Authors: Oganezi Nuria , Ojimelukwe Philippa C
Published: June 2023

To improve the traditional use of Moringa oleifera for the management of type 2 diabetes, the potent plant parts (seeds, leaves, stem bark, roots) must be specified and the appropriate dosage should be quantified. This research reports quantitative findings on the antihyperglycaemic properties of M. oleifera leaves. Streptozotocin (STZ) induced type 2 diabetic Wistar rats, were treated with iterative levels of the ethanolic leaf extract of Moringa oleifera (X1). Time of exposure (X2) of the rats to the extract, concentration, and time of storage of the leaf sample before extraction (X3) were monitored. The biomarkers of type 2 diabetes in the rats were monitored in a response surface model to optimize the ideal conditions for the antihyperglycaemic effects of M oleifera leaves. Haemoglobin count increased from ≤11.25mmol/L) to 15.88 mmol/L) as the dose of the extract and time increased. Diabetic rats were glutathione deficient (70-98 mg/ml), which improved to 300mg/dL after treatment. Serum Superoxide dismutase (SOD) was 170 mm/moL in diabetic rats and 300 mmol/mL in fully treated rats. Blood glucose of STZ-induced diabetic rats (over 220mg/dL) decreased to normal levels of 70-90 mg/dl. The extract was safe at 2250 mg/kg body weight. Fifty (50) g of shade-dried ethanolic extract of M. oleifera leaves stored for less than 3 months restored STZ-induced diabetes in Wistar rats within 28 days.
Brain multi-contrast, multi-atlas segmentation of diffusion tensor imaging and ensemble learning automatically diagnose late-life depression
Authors: Siarkos Kostas , Karavassilis Efstratios , Velonakis Georgios , Papageorgiou Charalabos , Smyrnis Nikolaos , Kelekis Nikolaos , Politis Antonios
Published: June 2023

We aimed to develop a machine learning model for diagnostic classification in late-life major depression based on an advanced whole brain white matter segmentation framework. Twenty six late-life depression and 12 never depressed individuals aged > 55 years, matched for age, MMSE, and education underwent diffusion tensor magnetic resonance imaging and multi-contrast, multi-atlas segmentation in MRIcloud. Fractional anisotropy volume, mean fractional anisotropy, trace, axial and radial diffusivity extracted from 146 white matter parcels were used to train and test the AdaBoost classifier using 12-fold cross validation. Performance was evaluated using accuracy, balanced accuracy, precision, and recall, F1-score and area under the receiver operator characteristic curve. Statistical significance of the classifier was assessed using standard label permutation and area under the receiver operator characteristic curve scores’ comparison. The classifier achieved a balanced accuracy, of 71% and an area under the receiver operator characteristic curve of 0.81 by trace, and a balanced accuracy of 70% and an area under the receiver operator characteristic curve, of 0.80, by radial diffusivity, in limbic, cortico-basal ganglia-thalamo-cortical loop, brainstem, external and internal capsules, callosal and cerebellar structures. Both indices shared important structures for classification, while fornix was the most important structure for classification by both indices. The classifier proved statistically significant, as area under the receiver operator characteristic curve scores after permutation were lower than those with the actual data, by trace (p = 0.022) and radial diffusivity (p = 0.024). The results encourage further investigation of the implemented methods for computer aided-diagnostics and anatomically-informed therapeutics.
Influence of the fractional-order strain on an infinite material with a spherical cavity under Green-Naghdi hyperbolic two-temperature thermoelasticity theory
Authors: Youssef Hamdy M. , Alghamdi Abdulrahman A.
Published: June 2023

In this work, a novel mathematical model of thermoelastic, homogenous, isotropic, and infinite medium with a spherical cavity has been constructed. Under the hyperbolic two-temperature Green-Naghdi theory of thermoelasticity type-I and type-III with fractional-order strain, the governing equations have been established. The bounding surface of the cavity has been thermally loaded by a ramp-type heat and is connected to a rigid foundation which prevents volumetric strain. Different values of the fractional-order and two-temperature parameters have shown numerical results for the dynamical and conductive temperature increment, strain, displacement, and average of principal stresses, which are graphically applicable to all the functions studied. The fractional-order parameter has significant effects on stress and strain distributions, while it has a limited effect on the dynamical and conductive temperatures increment. The hyperbolic two-temperature parameter has significant effects on all studied functions based on Green-Naghdi models of type-1 and type-II. Moreover, the ramp-time heat parameter has a significant impact on all the studied functions under all the studied models of thermoelasticity.
Prevention of Large Deformation of Soft Surrounding Rock in Tunnel Construction
Authors: Suo Xiaoqing , Gao Feng , Hu Bo , Zhang Xuefu , Qu Rui
Published: June 2023

Large deformation of surrounding rock makes the internal space of a tunnel cannot meet the requirements of normal use after support, even leads to the instability of surrounding rock and destruction of the tunnel structure. In order to optimize the parameters of the primary support to control the deformation of surrounding rock, field tests and numerical simulations are carried out. Based on the engineering geological conditions and the deformation monitoring data of surrounding rock, four important creep parameters of the improved Burgers model are inversed by numerical simulation, considering the creep of surrounding rock in tunnel construction. The results show that it is feasible to use tunnel crown settlement as a control indicator to determine the thickness of shotcrete. Short rock bolts are preferentially used in the tunnel arches, and a combination of long and short rock bolts should be used on the sidewall to control the large deformation of surrounding rock. When the excavation method of upper-lower bench is used in the single-track railway with a relatively large high-span ratio, the horizontal convergence monitoring points of the upper bench are recommended to be set 0.8-0.9 times the height of the upper bench from the tunnel arch crown, and those of the lower bench are recommended to be set 0.6-0.7 times the total height of the upper-lower bench from the tunnel arch crown.
Data monitoring for indirect metering terminal of membrane gas measure device based on sensor network
Authors: Gao Li , Che Lulu
Published: June 2023

In order to improve the data monitoring and information management capabilities of membrane gas measure device indirect metering terminals, a sensor network based data monitoring method for membrane gas measure device indirect metering terminals was proposed. The distributed and centralized sensor network node deployment method is used to achieve data collection for membrane gas measure device indirect metering terminals, and the collected membrane gas measure device indirect metering terminal data is segmented, fused, and reorganized. The distributed energy storage and constant volume two-level optimal control method is used to analyze the operation status of gas measure device indirect metering terminal data. The ZigBee networking protocol is used to build a network structure model for gas measure device indirect metering terminals, an integrated high-precision temperature and pressure sensor arranged parallel to the inner wall of the valve body is used to detect the temperature and pressure at the outlet of the membrane gas measure device. The temperature information is stored in DSP, and the user's expenses, system operation and maintenance, and peak shaving and valley filling benefits are taken as the parameters of the energy storage and constant volume outer layer model. The output stability of the indirect metering terminal data of the membrane gas measure device is analyzed in the high switching frequency mode. Combined with adaptive parameter adjustment, the indirect metering terminal control and data dynamic collection of the membrane gas measure device are realized. Realize dynamic monitoring of metering terminal data in wireless sensor network networking control mode. The test results show that using this method for indirect metering terminal data monitoring of gas measure devices has good output stability, strong dynamic fusion of sensing information, reduced metering errors, and improved metering accuracy of gas measure devices.
Study on water and gas permeation characteristics with ZIF-8 mixed matrix membranes
Authors: Gawali Ajay , Gawali Sapna , Jampa Surendra Sasikumar , Sinha Manish Kumar , Pandya Jalaja , Shinde Satyam , Khuntia Snigdha
Published: June 2023

The membrane separation process lacks intrinsic permeation characteristics to compete with other separation technologies like adsorption, sedimentation, coagulation, skimming, and distillation. A mixed matrix membrane (MMM) is one of the strategies to improve the separation characteristics with embedded nanofillers particles. Zeolite imidazolate framework (ZIF) has a new subclass of inorganic–organic hybrid materials that are being introduced as new fillers for incorporation into the polymer matrix for various applications such as oily wastewater separation, wastewater treatment, natural gas dehydration, landfill gas upgrading, and mixed gas separation. In this experimental work, a metal-organic framework called ZIF-8 was synthesized and used as a filler for modification of MMMs and characterized with FTIR and SEM. ZIF-8 nanoparticles up to 5 wt% loading were added to PSF casting solution then the permeation characteristics of MMMs showed an improved result like the pure water flux of the modified membrane at 2.5 bar was increased up to 456.38 L/m2h. In the case of pure gas separation, at 5 wt% ZIF-8 loading in PSF, the pure gas CO2 permeability at 9 bar pressure had increased to 10.54 barrer.
Implementation and Importance of Cardiac Rehabilitation for Cardiac
Patients in Saudi Arabia: A Systematic Review
Authors: Hadi Ahmed Raheeq , Bugis Bussma Ahmed
Published: June 2023

Objective:

Cardiac rehabilitation (CR) has progressed over the years from a basic monitoring
procedure for a safe return to physical activity to a multidisciplinary strategy that emphasizes patient
education, specifically for designed exercise training, risk factor management, and the general health of
cardiac patients.

Methods:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting
was used for this systematic review. The studies included were retrieved via an electronic search of
Google Scholar and PubMed using the following terms: cardiac rehabilitation (CR), cardiac diseases,
coronary artery bypass graft, heart failure, cardiac rehabilitation guidelines, rehabilitation, recovery of
function, cardiac rehabilitation importance, cardiac rehabilitation outcomes, physical therapy modalities,
secondary prevention, physical medicine, and cardiac rehabilitation phases.

Results:

Publications (n=24) that included worldwide standards demonstrating the implementation of
CR programs in a variety of scenarios were reviewed. These publications are based on well-defined
guidelines that represent best practices from several cardiology societies, which use varying valid programs
by comparing those guidelines with CR/secondary prevention programs.

Conclusion:

Several indications have been used in the development of the CR program, with the goal of
regaining autonomy and increasing physical, psychological, and social activities. With the Saudi Vision
2030 initiatives for health national transformation programs, there are targets set to ensure the reduction
and prevention of noncommunicable diseases and to reduce cardiovascular disease risks by initiating an
accredited CR program and guidelines for Saudi Arabia.
Synthesis and Cytotoxic Activity of Quinazoline-benzofuran Conjugates
Authors: Liu Yixin , Zou Nanting , Li Minxin , Wan Chunping , Mao Zewei
Published: June 2023

Aims:

In order to study on structure-activity relationships of benzofurans.

Background:

Benzofuran is a kind of natural compound widely existing in nature with pharmacological
effects. The development of new anticancer benzofuran derivatives has attracted more and
more attention.

Method:

We have introduced an active quinazoline unit into piperazine-substituted benzofuran,
prepared a series of quinazoline-benzofuran compounds, and evaluated cytotoxic activity against a
panel of human tumor cell lines by MTT assay.

Result:

48 novel quinazoline-substituted benzofuran derivatives have been prepared, and in vitro,
cytotoxic activity against five human tumor cell lines was evaluated. The results indicated that
some quinazoline-benzofuran conjugates showed selective inhibitory activity against tumor cell
lines.

Conclusion:

We have found that compound 14x displayed excellent cytotoxic activity, which
could be considered a potential anticancer agent.
Evolutionary Unmasking Resuscitative Therapeutics Potential of
Centhaquin Citrate in Hypovolemic Shock
Authors: Singh Ravinder , Singh Varinder , Kumari Pratima , Aggarwal Namita , Oberoi Muskaan , Khan Heena , Singh Thakur Gurjeet
Published: June 2023

Hypovolemic shock (HS), a clinical condition of insufficient blood perfusion and oxygenation
in body tissues, is associated with immense morbidity and mortality. Treatment approaches include
fluid replacement and surgical repair of reversible causes of hemorrhage; however, they cause
irreversible blood perfusion loss, systemic inflammation, multiple organ failure, and death. Centhaquin
citrate (CC) is an innovative centrally acting cardiovascular active agent that is initially intended
as an antihypertensive drug. However, due to its positive ionotropic effect, Centhaquin citrate
is being tested clinically as a resuscitative agent for the management of hypovolemic shock It acts at
the α2B-adrenergic receptor to produce venous constriction followed by an increase in venous return
to the heart. These actions are assumed to be capable of resuscitative activity observed by centhaquin
citrate, through an increase in cardiac output and tissue perfusion. Pharmacokinetics investigations in
animals and humans have shown that centhaquin citrate is well tolerated and has insignificant side effects.
Therefore, centhaquin citrate seems to be a promising entity and gaining the interest of researchers
to develop it as a resuscitative agent in HS. The review gives insight into the development of centhaquin
citrate as a resuscitative agent and provides insight into the associated mechanism of action
and molecular signalling to foster future research on CC for its clinical use in HS.
Liver Disorders Caused by Inborn Errors of Metabolism
Authors: Vakili Omid , Mafi Alireza , Pourfarzam Morteza
Published: June 2023

Inborn errors of metabolism (IEMs) are a vast array of inherited/congenital disorders, af-fecting a wide variety of metabolic pathways and/or biochemical processes inside the cells. Although IEMs are usually rare, they can be represented as serious health problems. During the neonatal period, these inherited defects can give rise to almost all key signs of liver malfunction, including jaundice, coagulopathy, hepato- and splenomegaly, ascites, etc. Since the liver is a vital organ with multiple synthetic, metabolic, and excretory functions, IEM-related hepatic dysfunction could seriously be con-sidered life-threatening. In this context, the identification of those hepatic manifestations and their associated characteristics may promote the differential diagnosis of IEMs immediately after birth, making therapeutic strategies more successful in preventing the occurrence of subsequent events. Among all possible liver defects caused by IEMs, cholestatic jaundice, hepatosplenomegaly, and liver failure have been shown to be manifested more frequently. Therefore, the current study aims to review substantial IEMs that mostly result in the aforementioned hepatic disorders, relying on clinical prin-ciples, especially through the first years of life. In this article, a group of uncommon hepatic manifes-tations linked to IEMs is also discussed in brief.
Role of Algal-derived Bioactive Compounds in Human Health
Authors: Tripathi Gyanendra , Dubey Priyanka , Ahmad Suhail , Farooqui Alvina , Mishra Vishal
Published: June 2023

Algae is emerging as a bioresource with high biological potential. Various algal strains have been used in traditional medicines and human diets worldwide. They are a rich source of bioactive compounds like ascorbic acid, riboflavin, pantothenate, biotin, folic acid, nicotinic acid, phycocyanins, gamma-linolenic acid (GLA), adrenic acid (ARA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), etc. Beta-carotene, astaxanthin, and phycobiliproteins are different classes of pigments that are found in algae. They possess antioxidant, anti-inflammatory and anticancer properties. The sulfur-coated polysaccharides in algae have been used as an anticancer, antibacterial, and antiviral agent. Scientists have exploited algal-derived bioactive compounds for developing lead molecules against several diseases. Due to the surge in research on bioactive molecules from algae, industries have started showing interest in patenting for the large-scale production of bioactive compounds having applications in sectors like pharmaceuticals, food, and beverage. In the food industry, algae are used as a thickening, gelling, and stabilizing agent. Due to their gelling and thickening characteristics, the most valuable algae products are macroalgal polysaccharides such as agar, alginates, and carrageenan. The high protein, lipid, and nutrient content in microalgae makes it a superfood for aquaculture. The present review aims at describing various non-energy-based applications of algae in pharmaceuticals, food and beverage, cosmetics, and nutraceuticals. This review attempts to analyze information on algal-derived drugs that have shown better potential and reached clinical trials.
Bio-inspired Computing Techniques and their Applications in Antennas
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Sundar Pattnaik Shyam
Published: June 2023

This chapter is dedicated to bio-inspired computing techniques and their
applications in antennas. The working principles of ANN, ANN Ensemble, GA, PSO,
and BFO are described, and some hybrid bio-inspired computing techniques are also
discussed. The literature survey related to the applications of bio-inspired computing
optimization techniques in antennas is given in this chapter. The limitations of the
existing bio-inspired computing techniques are highlighted. The existing applications
of bio-inspired computing techniques in fractal antennas are also reviewed in this
chapter.
Fractal Antennas
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Pattnaik Shyam Sundar
Published: June 2023

This chapter discusses fractal geometry concepts and fractal antennas.
Selected fractal antennas and their features are described, and all the designed fractal
antennas are introduced in this chapter. The important features like miniaturization &
multiband operation of the designed fractal antennas are highlighted, and their
applications are also discussed. 
Development of ANN Models for the Design of Fractal Antennas
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Pattnaik Shyam Sundar
Published: June 2023

In this chapter, the development of ANN models for the design of proposed
fractal antennas is explained. The various parameters of the fractal antennas selected
for ANN models are described. The ANN models are designed using feed-forward
neural networks, namely MLPNN, RBFNN and GRNN. The performance comparison
of different ANN models on the basis of different performance measures is also given.
The design of ANN ensemble models for fractal antennas is introduced, and different
techniques for developing ANN ensemble models are also discussed in this chapter. 
Pengaruh Pemberian Kromium Nitrat dan Kromium Klorida pada Tikus Wistar yang Diinduksi dengan Streptozotocin-Nicotinamide terhadap Gambaran Histologi Jantung
Authors: Putri Utami Amardi , Harjana Tri , Rahayu Tutiek
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian senyawa kromium nitrat dan kromium klorida terhadap histologi jantung tikus jantan galur Wistar yang diinduksi streptozotocin-nicotinamide. Jenis penelitian ini merupakan penelitian eksperimental dengan rancangan acak lengkap (RAL), menggunakan 2 kelompok kontrol dan 2 kelompok perlakuan, dilaksanakan selama 4 bulan. Tikus dibagi menjadi 4 kelompok perlakuan yaitu P1 (kromium nitrat), P2 (kromium klorida), K+ (kromium pikolinat) dan K- (Na-CMC). Variabel terikat berupa histologi jantung tikus berupa kerusakan pembuluh darah arteri dan nekrosis sel. Metode pengumpulan data dengan melakukan pengamatan histologi jantung menggunakan mikroskop cahaya. Data yang diperoleh dianalisis secara deskriptif, independent t test,uji Kruskal-Wallis dan uji One Way Anova. Hasil penelitian menunjukkan bahwa tikus yang diberi pelakuan kromium nitrat dan kromium klorida memberikan pengaruh yang tidak signifikan (p0,05) pada semua tahap nekrosis sel kecuali perbandingan kelompok P2 dan K- yang memberikan pengaruh secara signifikan (P0,05) pada tahap kariolisis dan memberikan pengaruh yang tidak signifikan (P0,05) dalam menurunkan kerusakan pembuluh darah arteri. Kata kunci: histologi jantung, kromium klorida, kromium nitrat, tikus
HIGIENE DAN SANITASI USAHA JASABOGA DI SETURAN, KECAMATAN DEPOK, KELURAHAN CATURTUNGGAL, D.I YOGYAKARTA
Authors: Wulandari Ayu , Rahayu Tutiek
Published: June 2023

Penelitian ini bertujuan untuk mengetahui penerapan higiene dan sanitasi serta keamananproduk yang dihasilkan pada usaha jasaboga di Seturan Kecamatan Depok, Kelurahan Caturtunggal,Kabupaten Sleman, D.I. Yogyakarta. Penelitian ini dilakukan dengan observasi ke usaha jasaboga.Penentuan lokasi dan sampel ayam bakar Padang dilakukan secara purposive sampling. Data hasilobservasi dari lembar scoring dianalisis dengan analisis statistik deskriptif, dimodifikasi dariKumpulan Modul Kursus Higiene dan Sanitasi Makanan dan Minuman Depkes RI. 2004. Hasilpenelitian menunjukkan bahwa penerapan higiene dan sanitasi pada proses penyajian di keduajasaboga cukup baik dibuktikan dengan hasil presentase yang didapat jasaboga A sebesar 81,25% danjasaboga B sebesar 79,16%, sedangkan standar baku mutu yang telah diterapkan yaitu 70%.Keamanan produk ayam bakar padang pada kedua jasaboga ialah baik dan aman untuk dikonsumsi,terbukti dengan tidak terdapatnya cemaran yang melebihi standar pada hasil pengujian bau, rasa,tekstur, kenampakan benda asing, pengujian pH, formalin, ALT dan keberadaan Staphylococcusaureus.Kata kunci: ayam bakar Padang, higiene, sanitasi, usaha jasaboga
Problems and Countermeasures in the Inheritance of Chinese Traditional Culture: the example of Chinese traditional patterns
Authors: Xiao Pan , Legino Rafeah
Published: June 2023

China is one of the world's ancient civilisations and has a long history of cultural forms. These traditional cultural forms are the carriers of the message of civilisation and have played an important role in the inheritance of the message of Chinese civilisation throughout the course of history. Because of the twists and turns of history, the challenges to the development and inheritance of Chinese culture have been innumerable. However, on the whole, the preservation and development of traditional Chinese culture has been relatively effective and successful in the modern era, and with the main force of the relevant policies and measures of the Chinese government, together with the collaboration of various institutions and international forces, traditional Chinese culture is moving into the future with a classical legacy and a new look in the new era. However, in the course of the author's research and study, some improvements can still be found in the system of preserving Chinese traditional culture. Chinese patterns are one of the brightest pearls of traditional Chinese culture, which comes from ancient times and is still very much alive today. However, there are also problems in their development and conservation. Therefore, this paper will use Chinese patterns as an example to study the way in which traditional Chinese culture is passed on and preserved and discuss the problems and propose countermeasures, in the hope of inspiring improvements to the issues involved.
Risk factors for burnout syndrome in nurses at a public hospital in Mossoró/RN, Brazil
Authors: Alves Bruna Nogueira , Freitas Camilla Cavalcante , Rocha Gabriel Sousa , Freire Marco Aurelio
Published: June 2023

Objective: To evaluate the risk factors for Burnout syndrome rise in nurses at the Tarcisio de Vasconcelos Maia Regional Hospital in Mossoró/RN. Methods: Exploratory, descriptive, prospective, quantitative and cross-sectional study in 119 nurses from March to September 2022, carried out under license from the Research Ethics Committee of UERN (#4,915,042). A questionnaire with socio-organizational information and the Copenhagen Burnout Inventory containing 19 items that reflect professional burnout, in a scale categorized as low, intermediate and high burnout, were applied. Results:  Most of the interviewees were female (81%), with an average of 36.4 years old, married (70%), with specialization in the area (74%), and two jobs (59%). It was possible to identify a higher prevalence of high levels of personal burnout (44%), and intermediate levels of work-related burnout (52%), and client-related burnout (50%). A strong positive correlation between the number of employment contracts for the dimensions personal (r=0.74, p=0.03) and work-related burnout (r=0.81, p=0.02), a strong positive correlation between workload and personal burnout (r=0.68, p=0.04), and a moderate positive correlation between workload and work-related burnout (r=0.53, p=0.04) were identified. Conclusions: Exposure to long workload resulted in increased levels of both physical and psychic exhaustion in nurses, negatively interfering with their professional performance and personal relationships. Future studies focusing on strategies to ensure a better working condition for nurses are needed, seeking approaches aimed at providing better occupational health for workers.
Evaluation of the social communication of children up to 12 years old with Autism Spectrum Disorder in a Psychosocial Care Center
Authors: Soares Rute Falcão , Freire Marco Aurelio M
Published: June 2023

Objective: To characterize social communication in children up to 12 years old diagnosed with Autistic Spectrum Disorder (ASD) treated at the Child Psychosocial Care Center (CAPSi) in Mossoró/RN. Methods: Exploratory, descriptive, quantitative, cross-sectional study conducted at CAPSi in Mossoró/RN. The data collection was based on the application of questionnaires to parents/guardians to characterize their socioeconomic conditions and their perception of their children. The Language Development Assessment (LDA) instrument for children was used, developed to assess the acquisition and development of language content (semantics) and structure (morphology and syntax). The questionnaires were coded, and the data were tabulated for further statistical analysis. Results: 33 children and 73 parents/guardians were studied. Most parents/guardians were female (95.9%), aged 30-39 years (mean age 37.6 years predominantly), with a partner (60%), with high school education (45%), and monthly income around one minimum wage (76.7%), having positive attitudes toward their children and noticing difficulties in their communication. In applying the questionnaire to the children, 63.7% presented results within the normal range, while 3% presented mild and 33.3% severe language alterations. Conclusion: Children with ASD attending CAPSi have language disorders in the pragmatic sublevel, and more than half of the participants did not have morphosyntactic and semantic changes.
Fuzzy Gaussian GARCH and Fuzzy Gaussian EGARCH Models: Foreign Exchange Market Forecast
Authors: Medina Reyes José Eduardo , Cabrera Llanos Agustín Ignacio , Cruz Aké Salvador
Published: June 2023

This article discusses a comparison of the GARCH and EGARCH conditional variance methods, with respect to the Fuzzy Gaussian GARCH and Fuzzy Gaussian EGARCH. The returns of four exchange rates were forecasted at daily periodicity from January 2015 to November 2022 and out-of-sample, January 2019, and December 2022. The results indicate that the Fuzzy GARCH and Fuzzy EGARCH models better estimate the volatility behaviour of the exchange market series compared to traditional techniques. Therefore, the recommendation is to estimate other high volatility variables to verify the efficiency of the fuzzy techniques, however, the main limitation is that it is not possible to apply traditional econometric tests for fuzzy techniques because the parameters are not estimated with the logarithm of maximum likelihood. The estimation of the parameters of GARCH and EGARCH models with fuzzy theory is the originality proposal. In conclusion, fuzzy methodologies have less error in forecasting the volatility of in-sample and out-of-sample exchange rates.
Potential Facilitators of and Barriers to Implementing the MINI Robot in Community-Based Meeting Centers for People With Dementia and Their Carers in the Netherlands and Spain: Explorative Qualitative Study
Authors: Mahmoudi Asl Aysan , Kouters Suzanne , Castro-González Álvaro , Van der Roest Henriëtte , Franco Martin Manuel , Dröes Rose-Marie
Published: June 2023

Background

Social robots, as a form of digital health technologies, are used to support emotional, cognitive, and physical care and have shown promising outcomes in enhancing social well-being in people with dementia (PwD) by boosting emotions, social interactions, and activity participation.

Objective

The goal is to investigate the attitude of stakeholders and potential facilitators and the barriers to implementing the social robot MINI in community-based meeting centers (MCs) for PwD and carers in the Netherlands and Spain.

Methods

Based on the British Medical Research Council guidance for process evaluation of the implementation of complex interventions and the model for tracing the facilitators of and barriers to the adaptive implementation of innovations in dementia care, an explorative qualitative study was conducted. Following the introduction of the MINI robot, 11 stakeholders were interviewed in 3 MCs in the Netherlands and 1 in Spain, as well as stakeholders in health and welfare organizations in both countries. In addition, 12 adults with dementia participated in focus groups. The data were thematically analyzed and narratively described.

Results

Overall, the stakeholder opinion and interest in the MINI robot were positive. The most important (expected) facilitating factors mentioned by stakeholders appeared to be human resources, funding, the impact of the MINI robot on the users and programs of the MCs, characteristics of the innovation, and collaboration with other care and welfare organizations. However, the (expected) barriers mentioned concerned the physical context and functionalities of the MINI robot, the user context, and MC activity policies.

Conclusions

The findings will inform professional stakeholders, such as MC directors and managers, as well as care and welfare organizations, on the practicality of using the MINI robot in MCs. Furthermore, our research will aid MINI robot developers in tailoring its features to PwD’s preferences and demands and MC policies, which will contribute to the MINI robot’s effective adoption and deployment.
Health Information on Pre-Exposure Prophylaxis From Search Engines and Twitter: Readability Analysis
Authors: Park Albert , Sayed Fatima , Robinson Patrick , Elopre Latesha , Ge Yaorong , Li Shaoyu , Grov Christian , Sullivan Patrick Sean
Published: June 2023

Background

Pre-exposure prophylaxis (PrEP) is proven to prevent HIV infection. However, PrEP uptake to date has been limited and inequitable. Analyzing the readability of existing PrEP-related information is important to understand the potential impact of available PrEP information on PrEP uptake and identify opportunities to improve PrEP-related education and communication.

Objective

We examined the readability of web-based PrEP information identified using search engines and on Twitter. We investigated the readability of web-based PrEP documents, stratified by how the PrEP document was obtained on the web, information source, document format and communication method, PrEP modality, and intended audience.

Methods

Web-based PrEP information in English was systematically identified using search engines and the Twitter API. We manually verified and categorized results and described the method used to obtain information, information source, document format and communication method, PrEP modality, and intended audience. Documents were converted to plain text for the analysis and readability of the collected documents was assessed using 4 readability indices. We conducted pairwise comparisons of readability based on how the PrEP document was obtained on the web, information source, document format, communication method, PrEP modality, and intended audience, then adjusted for multiple comparisons.

Results

A total of 463 documents were identified. Overall, the readability of web-based PrEP information was at a higher level (10.2-grade reading level) than what is recommended for health information provided to the general public (ninth-grade reading level, as suggested by the Department of Health and Human Services). Brochures (n=33, 7% of all identified resources) were the only type of PrEP materials that achieved the target of ninth-grade reading level.

Conclusions

Web-based PrEP information is often written at a complex level for potential and current PrEP users to understand. This may hinder PrEP uptake for some people who would benefit from it. The readability of PrEP-related information found on the web should be improved to align more closely with health communication guidelines for reading level to improve access to this important health information, facilitate informed decisions by those with a need for PrEP, and realize national prevention goals for PrEP uptake and reducing new HIV infections in the United States.
Resistance Training in Patients After Metabolic and Bariatric Surgery: Protocol for a Systematic Review (Preprint)
Authors: Elks Whitney , Rooks Adam , Schulte Spencer , Batra Kavita , Burke Jocelyn , Jain Varun
Published: June 2023

BACKGROUND

Resistance training has been consistently shown to have multiple health benefits, especially for patients who have undergone bariatric surgery. Patients who have undergone bariatric surgery are recommended to participate in resistance exercise; however, protocols and guidelines for resistance training remain poorly implemented.

OBJECTIVE

This is a protocol for a systematic review and possibly a meta-analysis that will synthesize evidence of the effects of resistance exercise on changes in body composition, muscular strength, overall weight loss or maintenance of weight loss, and quality of life in patients after metabolic and bariatric surgery (MBS). The findings of this study may provide practice recommendations for resistance training among patients who have undergone MBS.

METHODS

We registered this systematic review on PROSPERO (CRD42023464928) on September 18, 2023. A systematic search of electronic databases (Embase, PubMed, Scopus, Web of Science, and CINAHL) was conducted on studies published from January 1, 1991, to May 15, 2023, to identify English-language human studies on adult patients who have undergone MBS that include a resistance training intervention and describe outcome measurements of body composition or strength. Screening will be performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and relevant data elements will be extracted.

RESULTS

Searches and screenings commenced in May 2023. Data extraction and analyses will be completed by the end of December 2023, after which findings will be synthesized and reported by the end of March 2024.

CONCLUSIONS

This systematic review will summarize the evidence regarding resistance training in patients after MBS. The findings from this systematic review and possible meta-analysis may provide practice recommendations for resistance training protocols in this patient population and identify characteristics of protocols with the best adherence and outcomes. With these results, we anticipate that we will gain a deeper understanding of the role of resistance training after MBS.

CLINICALTRIAL

PROSPERO CRD42023464928; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=464928

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/49513
Sintaxis del jardín nahua
Authors:   Centro de Investigaciones en Arquitectura, Urbanismo y Paisaje. FA - UNAM, Rodríguez Figueroa Andrea Berenice
Published: June 2023

El libro que aquí se presenta tiene por objetivo explicar y mostrar la sintaxis o las reglas generales de diseño y planificación (distribución espacial) de los atributos que conforman el jardín nahua en el posclásico tardío (siglos XV y el primer cuarto del XVI) dentro de la zona centro de la cuenca de México. Ya en el libro Los jardines nahuas prehispánicos: una introducción desde la perspectiva de la arquitectura de paisaje (publicado en el 2021) se dieron a conocer los atributos de esos jardines y su función. Ahora corresponde tratar sobre las reglas de formación, distribución y planificación de esos jardines.
KUMPULAN CERITA ANAK SEMUT RAKSASA KARYA ANI ROSTIANI DKK.
Authors: Khajati Berti Nurul
Published: June 2023

Abstrak

Penelitian ini bertujuan untuk menganalisis lima unsur penguatan pendidikan karakter dalam kumpulan cerita anak Semut Raksasa karya Ani Rostiani dkk. yang dikaitkan dengan teori pendidikan karakter menurut Thomas Lickona, Ki Hajar Dewantara, dan Lawrence Kohlberg. Penelitian ini menggunakan paparan kualitatif deskriptif dengan metode analisis isi. Penelitian terhadap kumpulan cerita anak Semut Raksasa karya Ani Rostiani dkk. menghasilkan data analisis yang memuat lima unsur penguatan pendidikan karakter dengan proporsi seimbang pada lima poin yaitu unsur religius, nasionalis, mandiri, gotong royong dan integritas. Subnilai-subnilai yang terdapat dalam wacana yang dianalisis memiliki kesesuaian dengan teori pendidikan karakter menurut Thomas Lickona, Ki Hajar Dewantara, dan Lawrence Kohlberg. Berdasarkan temuan penelitian maka dapat diketahui bahwa unsur penguatan pendidikan karakter yaitu religius, nasionalis, mandiri, gotong royong dan integritas masing-masing terdapat dalam lima judul cerita dari sembilan judul yang diteliti. Dari penelitian ini dapat disimpulkan bahwa kumpulan cerita anak Semut Raksasa karya Ani Rostiani dkk. memuat unsur-unsur yang dibutuhkan dalam upaya penguatan pendidikan karakter sehingga layak digunakan sebagai materi pendukung dalam pembelajaran Bahasa Indonesia khususnya bagi siswa sekolah dasar.

Kata Kunci:

cerita anak, Semut Raksasa, Penguatan Pendidikan Karakter

 

Abstract  

This research aims to analyze the five elements of strengthening character education in the collection of children's stories Semut Raksasa by Ani Rostiani et al. which is associated with the theory of character education according to Thomas Lickona, Ki Hajar Dewantara, and Lawrence Kohlberg. This research uses descriptive qualitative exposure with content analysis method. Research on a collection of children's stories Semut Raksasa by Ani Rostiani et al. produce analytical data that contains five elements of strengthening character education with the balanced proportions at five points, namely religious, nationalist, independent, mutual cooperation and integrity elements. The sub-values contained in the analyzed discourse have conformity with the theory of character education according to Thomas Lickona, Ki Hajar Dewantara, and Lawrence Kohlberg. Based on the research findings, it can be seen that the elements of strengthening character education, namely religious, nationalist, independent, mutual cooperation and integrity are contained in five of the nine titles studied. From this research, it can be concluded that the collection of children's stories Semut Raksasa by Ani Rostiani et al. contains the elements needed in efforts to strengthen character so that it is appropriate to be used as supporting material in Indonesian language learning, especially for elementary school students.

Keywords: children's stories, Semut Raksasa, Strengthening Character Education
Buku Teks Bahasa Indonesia SMP Kelas VIII: Tinjauan Isi, Bahasa, dan Teknik Penyajian
Authors: Rifada Robhita Silmi Kaaffah
Published: June 2023

Penelitian ini bertujuan untuk mengetahui tingkat kelayakan buku teks ditinjau dari segi isi, bahasa, dan teknik penyajian. Penelitian ini berpendekatan kualitatif deskriptif dengan metode analisis isi. Hasil penelitian menunjukkan, bahwa pertama, materi buku teks sesuai dengan kompetensi dasar dalam Kurikulum 2013, kedua, bahasa penyajian buku teks sesuai dengan tingkat perkembangan bahasa siswa, dan ketiga, buku teks sangat sesuai dengan teknik penyajian dalam Kurikulum 2013. Buku teks bahasa Indonesia Mahir Berbahasa Indonesia, Jilid 2 Kelas VIII SMP/MTs layak digunakan sebagai sumber pembelajaran.dan klausa dwi-intransitif ini dapat membuat konstruksi kalimat menjadi lebih efektif dan sederhana.
Content Validity of English Summative Test
Authors: Rizky Hilaldy
Published: June 2023

The objective of the research was to answer the question of the study whether the content of the English summative test of the tenth grade students at SMA An-  Nurmaniyah in the 2016/2017 academic year was in line with the English syllabus content of 2013 Curriculum. In this research, the writer used descriptive comparative analysis. The writer compared a set of the English summative test content with a number of required items in the English syllabus content used in teaching and learning activities.The instruments were in the checklists forms which were arranged based on materials and objectives in syllabus of the 2013 Curriculum. The materials and objectives of each language skills were identified and arranged into the lists. They were changed into the questions as  instrument. The research found that the content validity of the English summative test which was administered at the school was quite appropriate with the syllabus content of 2013 Curriculum. The percentage of the materials the material conformity was 20%. Meanwhile, the the percentage of objective reading skill conformity was 57%. And then, the the percentage of objective writing skill conformity was 64% However, in the listening and speaking skills could not be analyzed because they did not exist in the summative test for tenth grade student. The benefit of the research result is to help the teacher to arrange and make a good test.