bluuebunny/crossref_metadata_2025 huggingface dataset:
Embracing Postcolonialism: The Future of Christian Education
Authors: Maddix Mark A.
Published: December 2018

The field of Christian education is changing due to globalization and contextualization of society, particularly as it relates to the ethnic demographics of the church. While much of the research and leadership in evangelical theology has historically been dominated by white males from the West, the field of postcolonial theologies and hermeneutics has implications for the church and the future of the field of Christian education. This article provides an overview of postcolonial studies (liberation theologies, feminist theology, and biblical hermeneutics) and how they are changing the scope of theological and biblical studies. Then the article gives focus to the impact of postcolonial studies on the field of Christian education by sketching out a way forward for future studies in Christian education.
Fabrication of low dielectric constant polyimide/TiO2 nanofibers with enhanced UV-light shielding properties
Authors: Wang Lei , Gong Guifen , Shen Junyao , Leng Jinsong
Published: December 2018

Polyimide (PI)/titanium dioxide (TiO2) composite nanofibers (NFs) with average diameters of 200–250 nm were synthesized via electrospinning. The total number density of dipoles decreased significantly, owing to the porous structures and compact interface between TiO2 NPs and PI matrix. All PI/TiO2 NFs maintain low dielectric constants and losses. For example, the dielectric constants of PI/TiO2-6% NFs are all lower than 2.6, being exposed to temperatures from 25°C to 200°C. Meantime, the dielectric losses of PI/TiO2-6% NFs are below 0.005. For ultraviolet (UV)-light shielding performance, the PI/TiO2 NFs exhibited good UV-light shielding and corresponding anti-photoaging properties. The reason can be ascribed from high UV-light absorption and scattering ability in the TiO2 NPs. The best UV-light absorption (average: 3.71) and corresponding absorption decay (15.13%) were achieved for optimized PI/TiO2-6% NFs. Other fundamental characteristics, such as the thermal stability, mechanical tensile property, and hydrophobicity, were also investigated. Such low dielectric constant PI/TiO2 composite NFs can be alternatively chosen under a longtime UV-light exposing condition.
‘Globalist war against humanity shifts into high gear’: Online anti-vaccination websites and ‘anti-public’ discourse
Authors: Davis Mark
Published: December 2018

Online media has provided unprecedented opportunities for anti-vaccination groups to spread their message. An extensive scholarly literature has consequently emerged to analyse such discourse and develop strategies for countering it. In this article, I take a different approach. My contention is that it is no longer appropriate to approach anti-vaccination discourse as a stand-alone formation. Such sites, I argue, building on work by McKenzie Wark and Bart Cammaerts, are increasingly part of a wider proliferation of ‘anti-public’ discourse that contests fundamental democratic conventions, rules of argumentation and so on. The article uses a mixed methods approach based on a systematic content survey supplemented by the presentation of qualitative examples from 56 anti-vaccination websites. By locating anti-vaccination discourse in these broader contexts, I argue, it is possible to understand it as related to a more general transformation in public deliberation.
Multicommunicator Aspirational Stress, Suggestions for Teaching and Research, and Other Insights After 10 Years of Multicommunication Research
Authors: Reinsch N. Lamar , Turner Jeanine Warisse
Published: December 2018

This study offers a comprehensive review of data-based research on the practice of multicommunicating, that is, the behavior of participating in multiple, overlapping conversations. Initial research has occurred in various academic disciplines and described the phenomenon with a variety of terms. The authors begin by defining multicommunication and then identifying and comparing these various other terms. Next, they summarize past research, offer revised versions of five propositions concerning multicommunicating, and identify a new concept, multicommunicator aspirational stress. Finally, they offer suggestions for both pedagogy and future research on multicommunicating.
Outcomes of In Situ Training for Disclosure as a Standalone and a Booster to a Child Protective Behaviors Education Program
Authors: White Codi , Shanley Dianne C. , Zimmer-Gembeck Melanie J. , Walsh Kerryann , Hawkins Russell , Lines Katrina
Published: December 2018

In this study, the effectiveness of the Observed Protective Behaviors behaviors test, a single-session, disclosure-focused, in situ skills training (IST), was evaluated as a standalone program (IST only) or as a booster to the child protective education program, Learn to be safe with Emmy and friends ™ (program + IST). Participants included 281 Year 1 children (5–7 years; 52% male), randomly assigned to IST only, program + IST, program only or waitlist, and followed across 6 months. At each assessment, children completed interviews to assess their intention and confidence to disclose unsafe situations (disclosure intentions and confidence) and their ability to identify unsafe situations (safety identification skills). Children also reported their anxiety symptoms to assess for a possible iatrogenic effect. The IST-only condition was effective, with children showing increased disclosure intentions relative to waitlist children. The program + IST condition was also effective, with children showing increased disclosure intentions relative to children in the waitlist or program-only conditions as well as greater increases in disclosure confidence relative to waitlist children. No differences were observed between conditions in children’s safety identification skills, and no iatrogenic effect on anxiety was found. Future research may seek to develop an IST that will also boost children’s safety identification skills.
Impacts of International Baccalaureate programmes on teaching and learning: A review of the literature
Authors: Dickson Anisah , Perry Laura B. , Ledger Susan
Published: December 2018

International Baccalaureate (IB) programmes are growing rapidly worldwide, driven in part by their global reputation and concept-driven, inquiry-based approach to teaching and learning. This thematic review of a range of literature sources examines the impact of IB programmes on teaching and learning, highlighting trends, challenges, and benefits. Findings of the review revealed that most of the studies, both qualitative and quantitative, examined stakeholders’ perspectives or self-reported experiences of IB programmes; a very small number used research designs that control for confounding factors or allow causal inferences to be drawn. A wide range of stakeholders report that IB programmes develop research and critical thinking skills, intercultural appreciation and global awareness, as well as cultivate collaborative working cultures and creative pedagogical practices among teachers. Challenges include extra demands on teachers for lesson planning and assessment, additional stress for teachers and students, and competing demands and expectations with national requirements. Recommendations are provided which may guide future research endeavours.
Cross-Flow Drying and Curing of Wet-Laid Glass Fiber Veils
Authors: Heil C.
Published: December 2018

Glass fiber veil is produced with a wet forming process, after which the veil is dried in a wire-type cross-flow dryer. The wet nonwoven web structure of glass fibers and binder undergoes the drying process under specific conditions as air velocity, air temperature and air humidity, each of which can be controlled separately. Drying is an important process step, which highly defines the end product properties of the glass fiber veil.

A simulation model is presented that give the opportunity for a better understanding of the cross-flow drying process in relation to product and process properties, and also a better controllability and a better energy management of the drying process. Thermocouples placed beneath the supporting transport wire and air humidity sensors in the dryer sections are the key for evaluation of important non-measurable drying air and glass web properties. The model has been validated using correction factors for heat and mass transfer and assuming leaking air flows between the dryer sections.

The impact of the underlying work goes further in the direction of understanding some related product and process problems: (1) There is an explicit binder migration process from the wet glass web to the wet upper surface of the supporting transport wire, while flash-drying of the wet web proceeds on the dry and hot wire surface. (2) The drying process of wet glass fibers and wet binder gels proceeds at a specific temperature under which a solid binder film forming process occurs. Control of the temperature and time for solid film forming in the whole fiber web structure can be effectuated in this way.

The relevance of the simulation model may be proved by continuous inline measurements at the production line.
Use of Nonwovens of Variable Porosity as Noise Control Elements
Authors: Shoshani Yakir , Yakubov Yakov
Published: December 2018

The optimal design of multilayer combinations of nonwoven fiberwebs is of prime importance in their applications as noise control elements. Such combinations can be simulated as a single layer with variable characteristics along the propagation of the sound wave. The paper examines the effect of variation of porosity on the sound absorption coefficients of three webs made of cotton, acrylic fibers and polyester.

The numerical procedure is based upon our generalization of the C. Zwikker and C.W. Kosten theory on sound transfer through porous media reported elsewhere. We have considered four functional forms of the porosity: linear, quadratic, exponential and logarithmic. Our results clearly indicate that for all materials considered the logarithmic form yields the highest noise absorption coefficients for f=1000 Hz.
Polymeric Nanofibers and Nanofiber Webs: A New Class of Nonwovens
Authors: Grafe Timothy , Graham Kristine
Published: December 2018

Nanofiber is a broad phrase generally referring to a fiber with a diameter less than 1 micron. While glass fibers have existed in the sub-micron range for some time and polymeric meltblown fibers are just beginning to break the micron barrier, 0.25 micron diameter electrospun nanofibers have been manufactured and used commercially for air filtration applications for more than twenty years. Several value-added nonwoven applications, including filtration, barrier fabrics, wipes, personal care, medical and pharmaceutical applications may benefit from the interesting technical properties of commercially available nanofibers and nanofiber webs.

This paper will discuss the electrospinning process for making nanofibers and nonwoven nanofiber webs from synthetic fiber-forming polymers. The resulting physical characteristics of the nanofiber webs will be discussed. In order to provide a useful context for the nonwovens industry, nanofiber webs will be compared to both melt-blown and spunbond nonwovens. The description and comparison of the properties should provide product designers in the nonwovens industry with the tools to generate product and applications ideas about new uses for nanofibers.
Electret Media for HVAC Filtration Applications
Authors: Myers David L. , Arnold B. Dean
Published: December 2018

Air filters produced with charged, or electret, media for HVAC filtration applications have gained significant market share and acceptance over the past few years. While these filters provide the advantage of high initial efficiency and low pressure drop, there are concerns about their ability to maintain efficiency in service. Furthermore, there is a tendency to classify all electret media in the same general category without any consideration of media structure, fiber size, and charging technique. Current research suggests that a variety of factors influence the loss of efficiency in use including humidity, exposure to certain chemicals, aging, temperature, and etc. While this is true of some charged media, the effect of environmental factors on filtration performance is highly dependent upon the media technology itself. This paper provides an overview of current electret media types detailing media structure and charging techniques. Fundamental impact of environmental factors on filtration performance is presented along with field studies detailing in-use performance of filterers manufactured with charged media.
Numerical Modeling of Thermobonded Nonwovens
Authors: Mueller Dieter H. , Kochmann Markus
Published: December 2018

In thermobonded nonwovens, the design of the bond point geometry is of major importance to the desired mechanical behavior. Despite the geometry's significance the selection is subject to a trial and error approach.

This paper describes a numerical method for the prediction of the nonwovens tensile behavior depending on the bond point geometry and process parameters.

The tensile behavior of thermobonded nonwovens is modeled in a numerical model using the Finite Element Method (FEM). The approach covers the influence of the shape and size of the bonded area as well as the properties of the non-woven. The influence of the technological parameters during the bonding process such as process temperature and pressure, are also covered.

The solidified area within the bond point is represented using solid elements. The connection between the bonded areas is modeled using link elements, representing the connecting fibers. This approach covers the nonlinear behavior caused by the fiber material properties and geometry. Sets of fibers are combined into fiber bundles in order to reduce the numerical effort. The fiber orientation within the nonwoven is taken into account in order to represent the different fiber distributions caused by the nonwovens production techniques.

The mechanical properties of fibers and fiber bundles are taken from experimental data and are mapped onto the model. The model is verified using experimental data from tensile testing.
Probabilistic Model Development of Web Structure Formation in the Melt Blowing Process
Authors: Chhabra Rajeev , Shambaugh Robert L.
Published: December 2018

A probabilistic modeling approach has been proposed to correlate motion of a filament to the web structural formation in single filament melt blowing. By treating fiber motion as a Markov process, a probabilistic space has been determined where fiber has a greatest chance of being present in the web structure and in its flight to the collection system. Based on the positional probabilities, a single fiber's motion space has been determined to be correlated to its diameter. Experimental data show that any process or material variable that leads to a variation in fiber diameter affects the lateral spread of fiber motion, and thereby web structure formation in a single filament melt blowing process.
Air Velocity, Air Temperature, Fiber Vibration and Fiber Diameter Measurements on a Practical Melt Blowing Die
Authors: Moore Eric M. , Papavassiliou Dimitrios V. , Shambaugh Robert L.
Published: December 2018

Numerous measurements were taken during the operation of a practical melt blowing slot die. On-line measurements were taken of the mean velocity and temperature of the air jets. Also, on-line measurements of fiber vibration amplitude were done. Off-line measurements were taken to determine fiber diameter distributions in the nonwoven webs. The light absorbance of these non-woven mats was measured and related to fiber diameter distribution and mat basis weight. Process conditions were varied across the operating range of the die to produce a variety of finished mats. It was found that the mean air velocity and temperature decayed in a manner similar to that observed in both laboratory-scale melt blowing dies and (more generally) in rectangular jets. Fiber vibrations were found to be strongly dependent on operating temperature and air flow rate. The fiber light absorbance correlated well with the projected area of the fibers present in the mat.
Structure-Process-Property Relationships in Hydroentangled Nonwovens -Part 1: Preliminary Experimental Observations
Authors: Pourdeyhimi Behnam , Minton Amy , Putnam Mike , Kim Han Seong
Published: December 2018

Hydroentanglement describes a versatile process for manufacturing nonwoven fabrics using fine, closely spaced, high-velocity jets of water to entangle loose arrays of fibers. The resultant fabrics rely primarily on fiber-to-fiber friction to achieve physical integrity and are characterized by relatively high strength, flexibility, and conformability. These technologies can use efficiently the majority of all types of fibers and produce fabrics that could achieve properties equivalent to wovens.

To develop a method for predicting the mechanical performance of hydroentangled nonwovens, one must first gather critical information about the materials, the web and the process to establish a detailed knowledge base. The first step in this process is to establish the role that the hydroentangling process parameters play in controlling the performance of the product. One must establish how efficient entanglement is attained, how such entanglement is translated into tensile and other physical properties as well as understanding the role of the intrinsic fiber properties that interact with the process.

This is the first in a series of papers planned for dealing with structure-process-property relationships in hydroentangled nonwovens.
Using Computational Fluid Dynamics to Simulate Flow Fields from various Melt Blowing Dies
Authors: Krutka Holly M. , Shambaugh Robert L. , Papavassiliou Dimitrios V.
Published: December 2018

This paper is an investigation of the flow fields generated by dual rectangular jets. Specifically, the jets examined are the same as the common slot dies used in the industrial melt blowing process. In this process, a molten polymer is attenuated by air discharging from dual jets. The velocity and turbulence of these flow fields determine the rate and quality of polymer fiber production. The flow field characteristics can be simulated quickly and efficiently using computational fluid dynamics (CFD). These CFD simulations require the use of an appropriate length scale to describe the flow field. This paper describes how these CFD simulations can be used to compare the flow fields generated by different jet geometries.
How to … Level Temperature Profiles for Mat Line Dryers
Authors: Henry William R.
Published: December 2018

In addition to achieving a consistent mat formation and binder application, it is the uniformity of subsequent drying and curing that is critical to the production of high-quality thermoset nonwoven mats. Uneven drying and/or curing, especially in the cross-machine direction will result in over/under drying/curing, edge curls, web breaks and high trim and/or scrap factors. This paper reviews several design and set-up techniques that have resulted in cross-machine temperature profiles as low as +/- 1°F on a web 16 feet wide. The recent start-up of a line producing fiberglass mat (roofing shingle substrate) serves to illustrate how the control of air mixing, distribution, and flow through the product can be combined to produce a level web temperature profile. While the results pertain to a new production line, the techniques for reducing web temperature profiles may also be applied to existing dryer equipment
Multiple Organ Lesions in a Case of Contamination With Multiple Radionuclides After 38 Years
Authors: Bian Huahui , Wang Youyou , Chen Weibo , Zhang Yusong , Zhuang Zhixiang , Xia Rui , Dai Hong , Feng Junchao , Pu Wangyang , Chen Lei , Cai Wu , Hu Wentao , Liu Yulong
Published: December 2018

The patient was contaminated with multiple radionuclides 38 years ago due to an accident. To investigate the effects of radionuclide contamination on humans, he has been followed up by examinations for many years. Long-term effects gradually emerge in these years. Lung cancer was diagnosed by medical examinations. Besides, chronic gastritis with intestinal metaplasia was indicated by gastroscopic biopsies, while colorectal polyps found by colonoscopy. All 13 colorectal polyps were removed, and radical surgery for lung cancer was performed. Fortunately, pathological examinations indicated that it was early lung cancer. The ground glass nodule (GGN) in left lung identified during the follow-up will be resected when needed. It is speculated that multiple manifestations of the patient may be related to radiation, and different lesions in the organs may be related to systemic adaptive response. However, longer follow-up is needed due to a lack of effective and direct evidence. This work is expected to provide experiences for similar patients’ treatment and follow-up.
Lifestyle Medicine: Successful Reimbursement Methods and Practice Models
Authors: Jensen Laura L. , Drozek David S. , Grega Meagan L. , Gobble John
Published: December 2018

Preventable and reversible chronic diseases affect millions of Americans, costing the United States billions of dollars annually for treatments that slow the trajectory but fail to address the root cause of illness. Lifestyle medicine is efficacious, and research has shown that this medical approach garners a significant return on investment in the treatment of many chronic diseases. To obtain an overview of successful reimbursement and practice models used by practitioners, American College of Lifestyle Medicine members were invited to participate in an online survey regarding their experience with lifestyle medicine services and reimbursement models. Three hundred and fifty-one respondents with diverse practice structures, geographical locations, and educational backgrounds completed the survey. The results demonstrate that practitioners are utilizing a variety of lifestyle medicine programs and reimbursement and practice models. Seventy-four percent of respondents are currently providing lifestyle medicine, though the majority do not receive reimbursement for their services. This study provides examples of successful lifestyle medicine reimbursement and practice models, as well as demonstrates the need for continued advocacy for sustainable reimbursement of lifestyle medicine services.
Attractions to Fuel the Imagination: Reframing Understandings of the Role of Distraction Relative to Well-Being in the Pediatric Hospital
Authors: McLaughlan Rebecca , Sadek Ahmed , Willis Julie
Published: December 2018

Objective:

Ulrich’s (1991) definition of “positive distraction” includes that which “elicits positive feelings and holds attention,” implying that the capacity of an environmental feature to hold attention is a necessary component. This article examines whether, in the context of a pediatric hospital, a distraction needs to “hold attention” to secure positive benefits for patient well-being.

Background:

Data collected from 246 patients at Melbourne’s Royal Children’s Hospital (Australia) revealed a discrepancy between what children and young people told us they did, and valued, within the hospital, relative to the time they spent engaging in, or paying attention to, these same features. This motivated a closer interrogation of the relationship between well-being, distraction, and socialization within the pediatric context.

Method:

Data were collected using a mixed-methods approach that included 178 surveys, 43 drawings contributed by patients/siblings within the outpatient waiting room, 25 photo-elicitation interviews with patients, and 100 hr of spatial observations within public and waiting room spaces. This was supplemented by interviews with architects and hospital staff.

Conclusions:

The mechanism by which we have understood positive distraction to contribute to well-being within the pediatric hospital environment is more complex than existing models accept. Within this context, environmental features that can positively transform expectations of visiting the hospital—that can ignite the imagination and incite a desire to return—can offer significant benefits to well-being. This is particularly relevant in the context of absenteeism from outpatient appointments and in reducing patient resistance to future, or ongoing, treatments.
Granular cell tumor of the breast mimicking malignancy: a case report with a literature review
Authors: Fujiwara Keishi , Maeda Ichiro , Mimura Hidefumi
Published: December 2018

Granular cell tumor (GCT) is a rare neoplasm of the soft tissues and <1% of all GCTs are malignant. Initially, GCT was considered a myogenic lesion affecting the female breast (myoblastoma). We report the case of an 83-year-old woman with a palpable lump in the left breast; mammography and ultrasound showed an irregular lesion. It was difficult to differentiate it from a malignant lesion; therefore, we performed core needle biopsy and histopathologic examination and immunohistochemical studies revealed a GCT of the breast.
Cell migration–inducing hyaluronan-binding protein is regulated by miR-140-3p and promotes the growth and invasion of colorectal cancer cells
Authors: Yang Xiao-Di , Yang Bi-Wei , Jiang Sen , Chen Xiao-Yu , Ye Tao , Zhang Jing
Published: December 2018

Dysregulation of cell migration–inducing hyaluronan-binding protein (CEMIP) is associated with the growth and metastasis of multiple malignancies. But, the underlying mechanism by which CEMIP contributes to colorectal cancer (CRC) remains undocumented. The association of CEMIP or miR-140-3p expression with clinicopathological characteristics and prognosis in CRC patients was analyzed by the tissue microarray and TCGA dataset. MiR-140-3p-specific binding with CEMIP was confirmed by luciferase report assay. In vitro experiments were conducted to assess the effects of CEMIP on the growth and invasion of CRC cells. Consequently, we found that CEMIP expression was dramatically elevated in CRC tissues and associated with a poor prognosis in CRC patients. The upregulation of CEMIP was attributable to the dysregulation of miR-140-3p rather than its genetic and epigenetic alterations. Ectopic expression of CEMIP facilitated the cell viability, colony formation, and invasive potential, but silencing of CEMIP reversed these effects. Furthermore, CEMIP was identified as a direct target of miR-140-3p and attenuated miR-140-3p-induced anti-proliferation effects by regulating c-Myc, E-cadherin, and Twist-1 expression. MiR-140-3p indicated a negative correlation with CEMIP expression and was an independent prognostic factor of tumor recurrence in CRC patients. Taken together, CEMIP is regulated by miR-140-3p and promotes the growth and invasion of CRC cells. MiR-140-3p/CEMIP axis may represent the potential markers for CRC patients.
The epidemiology of acromioclavicular joint excision
Authors: McLean Michael , Hoban Katie , Gupta Rohit , Gibson Anthony , Brooksbank Andrew J. , Fazzi Umberto G. , Arthur Angus , Martin David , Jenkins Paul J. , Millar Neal L.
Published: December 2018

Background:

With the development of arthroscopic procedures such as subacromial decompression (ASAD) and rotator cuff repair (RCR), it is hypothesized that there may have been a similar rise in the performance of acromioclavicular joint excision (ACJE). The purpose of this study was to investigate the epidemiology of ACJE to examine incidence, surgical technique, age, gender of patients and associated procedures in an urban population.

Methods:

A prospectively collected surgical database was retrospectively examined to identify patients undergoing ACJE. Associated procedures such as ASAD or RCR were determined from these records. The demographic details (age and gender) were also recorded.

Results:

A total of 411 ACJEs were performed over the study period (n = 216 males, n = 195 female). The overall incidence increased from 9.3 per 100,000 in 2009, to a peak of 19.6 per 1,00,000 in 2013. In 349 patients, ACJE was undertaken as part of an arthroscopic procedure, of which 332 were ASAD+ACJE alone. The prevalence of arthroscopic ACJE in ASADs was 23.7% (349/1400). ACJE was performed as an open procedure in 62 (15%) cases. Those undergoing open ACJE were younger than those undergoing an arthroscopic procedure (mean difference 6.2 years, 95% CI 3.2–9.2, p < 0.001).

Conclusions:

We demonstrate an increasing incidence of ACJE in the general population. The groups of patients most likely to undergo ACJE are women aged between 45 and 54 years old, men aged 55–64 years and the most socioeconomically deprived. The higher incidence of ACJE in the most deprived socioeconomic quintile may have public health implications. Level of Evidence: II; retrospective design: prognosis study.
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation
Authors: Xiao Wenbin , Bharadwaj Maheetha , Levine Max , Farnoud Noushin , Pastore Friederike , Getta Bartlomiej M. , Hultquist Anne , Famulare Christopher , Medina Juan S. , Patel Minal A. , Gao Qi , Lewis Natasha , Pichardo Janine , Baik Jeeyeon , Shaffer Brian , Giralt Sergio , Rampal Raajit , Devlin Sean , Cimera Robert , Zhang Yanming , E. Arcila Maria , Papaemmanuil Elli , Levine Ross L. , Roshal Mikhail
Published: December 2018

The genetic aberrations that drive mixed phenotype acute leukemia (MPAL) remain largely unknown, with the exception of a small subset of MPALs harboring BCR-ABL1 and MLL translocations. We performed clinicopathologic and genetic evaluation of 52 presumptive MPAL cases at Memorial Sloan Kettering Cancer Center. Only 29 out of 52 (56%) cases were confirmed to be bona fide MPAL according to the 2016 World Heath Organization classification. We identified PHF6 and DNMT3A mutations as the most common recurrent mutations in MPAL, each occurring in 6 out of 26 (23%) cases. These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked predilection for T-lineage differentiation (5/6 PHF6 mutated, 6/6 DNMT3A mutated). PHF6-mutated MPAL occurred in a younger patient cohort compared with DNMT3A-mutated cases (median age, 27 years vs 61 years, P < .01). All 3 MPAL cases with both T- and B-lineage differentiation harbored PHF6 mutations. MPAL with T-lineage differentiation was associated with nodal or extramedullary involvement (9/15 [60%] vs 0, P = .001) and a higher relapse incidence (78% vs 22%, P = .017) compared with those without T-lineage differentiation. Sequencing studies on flow-cytometry–sorted populations demonstrated that PHF6 mutations are present in all blast compartments regardless of lineage differentiation with high variant allele frequency, implicating PHF6 as an early mutation in MPAL pathogenesis. In conclusion, PHF6 and DNMT3A mutations are the most common somatic alterations identified in MPAL and appear to define 2 distinct subgroups of MPAL with T-lineage differentiation with inferior outcomes.
Headscarf and job recruitment—lifting the veil of labour market discrimination
Authors: Leckcivilize Attakrit , Straub Alexander
Published: December 2018

This paper investigates effects of appearance and religious practice of job applicants on the hiring decision. We asked participants in our laboratory experiment to select fictitious candidates for an interview from a pool of CVs with comparable characteristics but different photos. Some photos were of the same Turkish women with and without a headscarf. We demonstrate the effects of appearance, ethnicity, and veiling simultaneously and propose underlying mechanisms. We find robust effects of appearance but heterogeneous effects of headscarf on callback rates based on types of occupations and recruiters’ characteristics. However, positive characteristics mitigate discrimination against headscarf and even reverse it.
Implementation of Computerized Physician Order Entry for Chemotherapy: A Latin American Experience
Authors: Valencia Fernando S. , Ruiz Rossana , Neciosup Silvia P. , Mas Luis A. , Aliaga Karina M. , Huaman Flor , Ruiz Jenny , Vasquez Edinson , Llacctahuaman Noel , Pedraza Robert , Paz Missael , Aguirre Willam , Gomez Henry L.
Published: December 2018

Purpose

We describe the implementation process of a computerized physician order entry (CPOE) for outpatient chemotherapy at a Latin American hospital, with the intent of providing other institutions with general guidance and insight through our experience.

Methods

In 2012, under the direction of the Department of Medicine of the Instituto Nacional de Enfermedades Neoplásicas, a multidisciplinary team composed of oncologists, nurses, pharmacists, and informatics engineers was formed to develop software for a CPOE for chemotherapy within a preexistent homegrown electronic medical record system in various phases. This included mapping and redesigning processes in an entirely electronic format, integrating the needs of the user for the development of electronic order sets, developing a checkpoint and a warning system to minimize prescription errors, and finally, training all the staff in implementation of the system.

Results

A CPOE for outpatient chemotherapy was successfully implemented in 2016. We have successfully standardized 266 chemotherapy orders, including for both solid tumors and hematologic malignancies, on the basis of appropriate guidelines. The software is linked to laboratory results and allows entry of important details for the patient's safety, such as anthropometric information for an automatic dose calculation and ranges for safe prescription. In addition, it is linked to the nursing plan sheets. Finally, it is possible to assess and continuously monitor the complex process of chemotherapy prescription.

Conclusion

This is the first report of implementation of a CPOE for chemotherapy in our region. The system was designed by a multidisciplinary team with its own resources. Our experience demonstrates the feasibility of computerizing the chemotherapy prescription process, constituting a tangible example for other institutions with potential impact on patient care.
The ATPase TER94 regulates Notch signaling duringDrosophilawing development
Authors: Li Yunlong , Liu Tong , Zhang Junzheng
Published: December 2018

The evolutionarily conserved Notch signaling pathway plays crucial roles in various developmental contexts. Multiple mechanisms are involved in regulation of the Notch pathway activity. Identified through a genetic mosaic screen, we show that the ATPase TER94 acts as a positive regulator of Notch signaling during Drosophila wing development. Depletion of TER94 causes marginal notches in the adult wing and reduction of Notch target genes wingless and cut during wing margin formation. We provide evidence that TER94 is likely required for proper Notch protein localization and activation. Furthermore, we show that knockdown of the TER94 adaptor dNpl4 leads to similar Notch signaling defects. Although the TER94 complex is implicated in various cellular processes, its role in the regulation of Notch pathways was previously uncharacterized. Our study demonstrates that TER94 positively regulates Notch signaling, thus reveals a novel role of TER94 in development.
Contribution of non-circadian neurons to the temporal organization of locomotor activity
Authors: Pírez Nicolás , Bernabei-Cornejo Sofia G. , Fernandez-Acosta Magdalena , Duhart José M. , Ceriani M. Fernanda
Published: December 2018

In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small Lateral Neurons ventral (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on its axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times along the day as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role on the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in Drosophila melanogaster.
Traction reinforcement in prehensile feet of harvestmen (Arachnida, Opiliones)
Authors: Wolff Jonas O. , Wiegmann Chantal , Wirkner Christian S. , Koehnsen Alexander , Gorb Stanislav N.
Published: December 2018

Prehensile and gripping organs are recurring structures in different organisms that enhance friction by the reinforcement and redirection of normal forces. The relationship between organ structure and biomechanical performance is poorly understood, despite a broad relevance for microhabitat choice, movement ecology and biomimetics. Here, we present the first study of the biomechanics of prehensile feet in long-legged harvestmen. These arachnids exhibit the strongest sub-division of legs among arthropods, permitting extreme hyper-flexion (i.e. curling up the foot tip). We found that despite the lack of adhesive foot pads, these moderately sized arthropods are able to scale vertical smooth surfaces, if the surface is curved. The comparison of three species of harvestmen differing in leg morphology show that traction reinforcement by foot wrapping depends on the degree of leg sub-division, not leg length. Differences are explained by adaptation to different microhabitats on trees. The exponential increase of foot section length from distal to proximal introduces a gradient of flexibility that permits adaptation to a wide range of surface curvature while maintaining integrity at strong flexion. A pulley system of the claw depressor tendon ensures the controlled flexion of the high number of adesmatic joints in the harvestman foot. These results contribute to the general understanding of foot function in arthropods and showcase an interesting model for the biomimetic engineering of novel transportation systems and surgical probes.
Uma ferramenta estratégica
Authors: Bogéa Felipe
Published: December 2018

O Social Media Canvas fornece um framework simples e holístico para definir a melhor forma de atuar nas mídias sociais.
Fronteiras nebulosas
Authors: Wilner Adriana , Christopoulos Tania Pereira , Alves Mário Aquino
Published: December 2018

As organizações expandem o controle sobre as manifestações dos funcionários nas redes sociais para lidar com a perda de domínio do conteúdo que é postado a seu respeito. No entanto, essa saída pode intensificar os conflitos.
Organizações ambidestras
Authors: Amantea Rodrigo
Published: December 2018

Para enfrentar um ambiente de mudanças aceleradas, é preciso combinar esforços de exploitation (refinar o que já existe) e exploration (criar novas oportunidades).
Boa notícia na política
Authors: Teixeira Marco Antonio Carvalho
Published: December 2018

Dos 35 partidos existentes, é provável que, em 2030, no máximo 20 consigam ter acesso aos recursos cruciais para sua sobrevivência.
Influence of different stocking density on the growth, feed efficiency, and survival of Majalaya common carp (Cyprinus carpio Linnaeus 1758)
Authors: Hayat Mir'atul , Nugroho Rudy Agung , Aryani Retno
Published: December 2018

Background: Stocking density is key to successful Majalaya common carp (Cyprinus carpio Linnaeus 1758) culture which is a valuable fish culture in Indonesia.  The aim of the present study was to evaluate the growth statues, feed utilization, and survival rate of Majalaya common carp (reared with different stocking density.

Methods: In total, 1400 fish were randomly distributed into four replicates of four different groups of stocking density: 50, 75, 100, and 125 fish m−3. All fish were fed using a satiation method, three times per day with commercial diet for 12 weeks. At the end of the trial week, growth, feed utilization, and survival were determined. Water quality measures, such as dissolved oxygen (mg L-1), temperature (°C), pH, NH3 (mg L-1), and NO2 (mg L-1) were also measured once a week during the trial.

Results: Similar weight gain and SGR were found in Majalaya common carp reared at stocking densities of 50 to 100 fish m3. However, 125 fish m-3 density may reduce weight gain and SGR. The average weekly and daily weight gain of Majalaya common carp significantly increased when reared from 50 to 100 fish m-3 and remained constant at 125 fish m-3 density. Meanwhile, feed conversion ratio and survival of Majalaya common carp were not affected by any stocking density.

Conclusions: A stocking density of 100 fish m-3 exhibited significantly higher growth of Majalaya common carp in hapa net ponds among the treatment. Temperature ranges of 29.20-33.38°C, pH 7.47-8.22, DO 4.76-7.55 (mg L-1), NH3 0-0.5 mg L-1, and NO2 0-1 mg L-1 were found to provide optimum condition to the fish.
Chicken feather hydrolysate as alternative peptone source for microbial cultivation
Authors: Akpor Oghenerobor B. , Odesola Damilola E. , Thomas Remilekun E. , Oluba Olarewaju M.
Published: December 2018

Background: Commercially available conventional growth medium for the culture of microbes are expensive, hence the need for alternative cheaper sources. Poultry waste, in the form of feather and blood, are of value in biotechnology because of their high protein content. Hence the primary aim of this study was to produce a cheaper peptone alternative from chicken feather protein hydrolysate (CFPH) and blood meal (BM).

Methods: We monitored the growth of selected bacteria and fungi in different concentrations of medium produced from varying combination of peptone, CFPH and BM in order to determine the combination that produced maximum growth. Five different media, namely 100% peptone (control), 100% BM, 40% peptone + 60% CFPH, 40% BM + 60% CFPH and 20% peptone + 20% BM + 60% CFPH were prepared and used for the study. The different media were inoculated with 1 ml of each test organism (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, Candida carpophila, Candida tropicalis and Pichia kundriavzevii) and their growth monitored for 10 h.

Results: Pseudomonas aeruginosa, Proteus mirabilis and Staphylococcus aureus grew best in the 100% peptone, Klebsiella pneumoniae grew best in 100 BM. The fungi species were observed to grow best in 100% peptone. The 60% CFPH + 40% peptone combination (CFPH obtained with precipitate of TCA, HCl, and HNO3 gave the best growth of E. coli.  The 60% CFPH + 40% peptone combination (CFPH obtained with precipitate of TCA) also gave the best growth of C. tropicalis and Klebsiella pneumoniae respectively.

Conclusions: Overall, the 60% CFPH + 40% peptone combination showed the most potential as an alternative to peptone, especially for E. coli.
From staff nurse to nurse consultant
Authors: Fowler John
Published: December 2018

John Fowler, Educational Consultant, highlights the importance of considering your own CPD needs in the context of what you really want to do, and how you could get there
Stoma formation after lymphoproliferative disorders and immunosuppression therapy
Authors: Fulham Juliette , Plucinski Micaela
Published: December 2018

Post-transplant lymphoproliferative disorders (PTLD) are lymphomas that may arise in organ, bone marrow or stem cell transplant recipients who are taking immunosuppressive drugs to prevent rejection of the transplant. The likelihood of developing PTLD depends on the type of transplant. PTLD is a potentially severe complication of post-transplant treatment, with an uncertain prognosis. Lymphoproliferative disorders can also occur in people taking immunosuppressants for inflammatory bowel disease. This article will explore PTLD and discuss the experience of caring for patients who developed lymphoproliferative conditions and required emergency stoma formation. The emotional and physical impact of surgery upon these patients, who have already experienced a protracted treatment journey, will be explored. Implications for practice for the lymphoma team and stoma nurse specialists involved with the care of these patients will also be considered.
The treatment and management of osteoarthritis
Authors: Ryan Sarah
Published: December 2018

This article will review the current evidence for the treatment and management of osteoarthritis (OA). OA is the most common musculoskeletal condition worldwide and patients will seek advice regarding management options from a number of healthcare providers including GPs, nurses, physiotherapists and pharmacists. There is no cure for OA, but there are effective treatments. This article will explain what OA is, the symptoms associated with structural changes to the joint and how OA is diagnosed. The effectiveness of non-pharmacological interventions including patient education, exercise and weight management will be explored. The role of medications including paracetamol, topical and oral non-steroid anti-inflammatory drugs will be included. The article will conclude by discussing when surgical intervention is advisable.
The controlled withdrawal of inhaled corticosteroids in patients with stable COPD in primary care
Authors: Dawson Linda
Published: December 2018

There is variety in the accuracy of diagnosis, classification and long-term management of chronic obstructive pulmonary disease (COPD) in the UK. Inhaled corticosteroids (ICSs) are habitually incorrectly prescribed for patients with COPD. Evidence supporting this practice has been considered ambivalent, and more recent guidance recommends that long-acting bronchodilators are the mainstay of treatment in patients with this disease. However, there are disparities in the guidelines and in practice and ICSs are repeatedly over-used. Consequently, ICSs should be used with caution in specific COPD patients who fit the criteria. Measured withdrawal of ICSs in such patients will support safe prescribing and evidence-based management and reduce the risk of adverse effects, thus delivering quality improvement in practice. This article will provide a brief review of the evidence around the use of ICSs in COPD. It will emphasise the evidence reinforcing the safe and effective discontinuation of ICS therapy in a subgroup of patients in primary care with stable COPD, in whom ICS therapy may not be indicated, and will consider a treatment paradigm that outlines guidance on COPD therapy inhaler step-down. The implementation process undertaken in practice will be critically evaluated, providing preliminary data of results to date.