bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: The Synthesis of Ambrox®‐Like Compounds Starting from (+)‐Larixol.
Authors: Bolster Marjon G. , Jansen Ben J. M. , de Groot Aede
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ozonolysis of Alkenes and Study of Reactions of Polyfunctional Compounds. Part 64. Synthesis of Ambreinolide (II) and 8α,13‐Epoxy‐14,15,16‐trisnorlabd‐12‐ene (III) Proceeding from Isoabienol (I) Ozonolysis.
Authors: Kukovinets O. S. , Zainullin R. A. , Odinokov V. N. , Kislitsyn M. I. , Roshchin V. I. , Galin F. Z. , Tolstikov G. A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antifolate Evaluation of the Aminopterin Analogue with a Bicyclo[2.2.2]octane Ring in Place of the Benzene Ring.
Authors: Reynolds Robert C. , Johnson Cheryl A. , Piper James R. , Sirotnak Frances M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Deprotection of N‐Boc‐Protected tert‐Butyl Ester Amino Acids by the CeCl3×7H2O—NaI System in Acetonitrile.
Authors: Marcantoni Enrico , Massaccesi Massimo , Torregiani Elisabetta , Bartoli Giuseppe , Bosco Marcella , Sambri Letizia
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Orally Active Antithrombotic Thioglycosides. Part 13. Conversion of 2,6‐Anhydro‐D‐altrose and ‐mannose Derivatives with 4‐Substituted Phenyl Thiols to Prepare Compounds with Potential Antithrombotic Activity.
Authors: Bozo Eva , Boros Sandor , Kuszmann Janos
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: De Novo Synthesis of a Methylene‐Bridged Neu5Ac‐α‐(2,3)‐Gal C‐Disaccharide.
Authors: Notz Wolfgang , Hartel Christian , Waldscheck Bernhard , Schmidt Richard R.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Hydrolytic and Transferase Action of Alternanase on Oligosaccharides.
Authors: Cote Gregory L. , Ahlgren Jeffrey A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure and Synthesis of Glycoborine, a New Carbazole Alkaloid from the Roots of Glycosmis arborea: A Note on the Structure of Glycozolicine.
Authors: Chakravarty Ajit Kumar , Sarkar Tapas , Masuda Kazuo , Takey Tesuya , Doi Hirohisa , Kotani Eiichi , Shiojima Kenji
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Immunotherapeutic Program for the Treatment of Nicotine Addiction: Hapten Design and Synthesis.
Authors: Isomura Shigeki , Wirsching Peter , Jenda Kim D.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Diastereoselective Intramolecular Hydroamination Approach to the Syntheses of (+)‐, (.+‐.)‐, and (‐)‐Pinidinol.
Authors: Molander Gary A. , Dowdy Eric D. , Pack Shawn K.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hyperaspine, a New 3‐Oxaquinolizidine Alkaloid from Hyperaspis campestris (Coleoptera: Coccinellidae)
Authors: Lebrun Benjamine , Braekman Jean‐Claude , Daloze Desire , Kalushkov Plamen , Pasteels Jacques M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrolytic Stability of Nucleoside Phosphotriesters Derived from Bis(hydroxymethyl)‐1,3‐dicarbonyl Compounds and Their Congeners: Towards a Novel Pro‐Drug Strategy for Antisense Oligonucleotides.
Authors: Ora Mikko , Maeki Esa , Poijaervi Paeivi , Neuvonen Kari , Oivannen Mikko , Loennberg Harri
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Revised Structure of Cercidinin A, a Novel Ellagitannin Having (R)‐Hexahydroxydiphenoyl Esters at the 3,4‐Positions of Glucopyranose.
Authors: Tanaka Takashi , Nonaka Gen‐ichiro , Ishimatsu Makoto , Nishioka Itsuo , Kouno Isao
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Myeloconone A2, a New Phenalenone from the Lichen Myeloconis erumpens.
Authors: Ernst‐Russell Michael A. , Chai Christina L. L. , Elix John A. , McCarthy Patrick M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Nitrogenous Constituents from the South African Marine Ascidian Pseudodistoma sp.
Authors: Rashid Mohammad A. , Gustafson Kirk R. , Cartner Laura K. , Pannell Lewis K. , Boyd Michael R.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the Two Main Urinary Tetranor Metabolites of 15‐F2t‐Isoprostane.
Authors: Durand Thierry , Henry Olivier , Vidal Jean‐Pierre , Rossi Jean‐Claude
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Identification of the Catalytic Nucleophiles of Two β‐Galactosidases from Glycoside Hydrolase Family 35.
Authors: Blanchard Jan E. , Gal Laurent , He Shouming , Foisy Janine , Warren R. Antony J. , Withers Stephen G.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies Directed Toward the Synthesis of Viridenomycin. Route 1: Assembly of Three Advanced Intermediates.
Authors: Kruger Albert W. , Meyers A. I.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Towards the Synthesis of (+)‐Discodermolide.
Authors: Yadav J. S. , Abraham Sunny , Reddy M. Muralidhar , Sabitha Gowravaram , Sankar A. Ravi , Kunwar A. C.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrolytic Kinetic Resolution of Mono‐ and Bisepoxides as a Key Step in the Synthesis of Insect Pheromones.
Authors: Chow Sharon , Kitching William
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Expeditious Synthesis of Pentosidine, an Advanced Glycation End Product.
Authors: Yokokawa Fumiaki , Sugiyama Hideyuki , Shioiri Takayuki , Katagiri Noriko , Oda Osamu , Ogawa Hiroshi
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Epicorazine C, an Antimicrobial Metabolite from Stereum hirsutum HKI 0195.
Authors: Kleinwaechter Peter , Dahse Hans‐Martin , Luhmann Udo , Schlegel Brigitte , Dornberger Klausjuergen
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Recognition by CD‐Sensitive Dimeric Zinc Porphyrin Host. Part 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines.
Authors: Kurtan Tibor , Nesnas Nasri , Li Yuan‐Qiang , Huang Xuefei , Nakanishi Koji , Berova Nina
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Activity of the AT1 Receptor Antagonists
Authors: Altmannsberger Stefan H. G. , Paneitz Andrea , Siegmund Werner , Kroemer Heyo K.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: AT1 Receptor Antagonists for Heart Failure
Authors: Duesing Rainer
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Electron‐Deficient Alkynes and Allenes under Phosphine Catalysis
Authors: Lu Xiyan , Zhang Chunming , Xu Zhenrong
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organophosphorus‐Based Organic/Inorganic Hybrids
Authors: Vioux Andre , Mutin P. Hubert , Le Bideau Jean , Leclercq Dominique
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of η5‐Fullerene Metal Complexes
Authors: Nakamura Eiichi , Sawamura Masaya
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: COX‐2 and a New Generation of NSAIDs
Authors: Xie Weilin
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Secretase Targets for Alzheimer′s Disease: Identification and Therapeutic Potential
Authors: Wolfe Michael S.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cooperative Bimetallic Oxidative Addition Reactions
Authors: Qin C. Jin , Gavrilova Anna , Bosnich B.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dynamics of cAMP‐Dependent Protein Kinase
Authors: Johnson David A. , Akamine Pearl , Radzio‐Andzelm Elzbieta , Madhusudan Madhusudan , Taylor Susan S.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Kinetic and Catalytic Mechanisms of Protein Kinases
Authors: Adams Joseph A.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Growth Factor‐Dependent Signaling and Cell Cycle Progression
Authors: Jones Steven M. , Kazlauskas Andrius
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: c‐Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes
Authors: Haskell Michelle D. , Slack Jill K. , Parsons J. Thomas , Parsons Sarah J.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: MAP Kinases
Authors: Chen Zhu , Gibson Tara Beers , Robinson Fred , Silvestro Loraine , Pearson Gray , Xu Bing‐e , Wright Angelique , Vanderbilt Colleen , Cobb Melanie H.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Data Needs in Astrochemistry
Authors: Millar T. J. , Walmsley C. M. , Rebrion‐Rowe C. , d'Hendecourt L. , Saito S. , Rostas F.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Specific Features of the Reactivity of Nitrothiolene 1,1‐Dioxides
Authors: Berestovitskaya V. M.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Infrared Spectroscopy in Solid‐Phase Synthesis
Authors: De Miguel Yolanda R. , Shearer Alison S.
Published: September 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development
Authors: Hoang Chinh Q. , Burnett Micheal E. , Curtiss Jennifer
Published: September 2010

Specification factors regulate cell fate in part by interacting with transcriptional co‐regulators like CtBP to regulate gene expression. Here, we demonstrate that CtBP forms a complex or complexes with the Drosophila melanogaster Pax6 homolog Eyeless (Ey), and with Distal antenna (Dan), Distal antenna related (Danr), and Dachshund to promote eye and antennal specification. Phenotypic analysis together with molecular data indicate that CtBP interacts with Ey to prevent overproliferation of eye precursors. In contrast, CtBP,dan,danr triple mutant adult eyes have significantly fewer ommatidia than CtBP single or dan,danr double mutants, suggesting that the CtBP/Dan/Danr complex functions to recruit ommatidia from the eye precursor pool. Furthermore, CtBP single and to a greater extent CtBP,dan,danr triple mutants affect the establishment and maintenance of the R8 precursor, which is the founding ommatidial cell. Thus, CtBP interacts with different eye specification factors to regulate gene expression appropriate for proliferative vs. differentiative stages of eye development. Developmental Dynamics 239:2367–2385, 2010. © 2010 Wiley‐Liss, Inc.
Ecological vulnerability in wildlife: Application of a species-ranking method to food chains and habitats
Authors: De Lange Hendrika J. , Lahr Joost , Van der Pol Joost J.C. , Faber Jack H.
Published: September 2010

Nature development in The Netherlands is often planned on contaminated soils or sediments. This contamination may present a risk for wildlife species desired at those nature development sites and must be assessed by specific risk assessment methods. In a previous study, we developed a method to predict ecological vulnerability in wildlife species by using autecological data and expert judgment; in the current study, this method is further extended to assess ecological vulnerability of food chains and terrestrial and aquatic habitats typical for The Netherlands. The method is applied to six chemicals: Cd, Cu, Zn, dichlorodiphenyltrichloroethane, chlorpyrifos, and ivermectin. The results indicate that species in different food chains differ in vulnerability, with earthworm-based food chains the most vulnerable. Within and between food chains, vulnerability varied with habitat, particularly at low trophic levels. The concept of habitat vulnerability was applied to a case study of four different habitat types in floodplains contaminated with cadmium and zinc along the river Dommel, The Netherlands. The alder floodplain forest habitat contained the most vulnerable species. The differences among habitats were significant for Cd. We further conclude that the method has good potential for application in mapping of habitat vulnerability. Environ. Toxicol. Chem. 2010;29:2875–2880. © 2010 SETAC
Optical Probes of Charge Generation and Recombination in Bulk Heterojunction Organic Solar Cells
Authors: Howard Ian A. , Laquai Frédéric
Published: September 2010

Recently, significant insight into the mechanisms of charge generation and recombination in interpenetrating networks of electron‐rich donor polymers and electron‐deficient acceptors used in bulk heterojunction organic solar cells has been gained through optical spectroscopy. In this article, we focus on the trend of using ultrafast transient absorption spectroscopy to observe structure–function relationships in order to provide valuable feedback and guidance for materials design and device engineering. Despite the progress, many research questions in this field still remain open, and we highlight areas in which experimental and theoretical work disagree or are still lacking. As examples of the unique and important insights that can be gained from optical spectroscopy, we review the influence of dielectric environment on charge transfer in donor–acceptor‐systems and the influence of morphology on charge generation and recombination in the prototypic photovoltaic blend system regioregular poly(3‐hexylthiophene) and [6,6]‐phenyl C61 butyric acid methyl ester (P3HT:PCBM).

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Kinetic Simulations of Atom Transfer Radical Polymerization (ATRP) in Light of Chain Length Dependent Termination
Authors: Johnston‐Hall Geoffrey , Monteiro Michael J.
Published: September 2010

Kinetic simulations using the composite kt model allows a better understanding of the effects of the persistent radical affecting ATRP or for that matter any activation–deactivation system. It also provides a better fit to experimental data in either bulk or solution conditions for ATRP polymerizations carried out at 110 °C. The results suggest that the composite model has broad utility over a wide range of experimental conditions and temperatures. The advantage of incorporating an accurate kt model is that one can then use simulations as predictive tool to obtain polymers with higher chain‐end fidelity or polymers with low PDI values. This becomes important when attempting to use the chain‐ends for further functionalization to make complex polymer architectures. This model can also be used in simulations of miniemulsion or seeded emulsions to determine the effect of compartmentalization with particle size.

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Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy
Authors: Morine Kevin J. , Bish Lawrence T. , Selsby Joshua T. , Gazzara Jeffery A. , Pendrak Klara , Sleeper Meg M. , Barton Elisabeth R. , Lee Se‐Jin , Sweeney H. Lee
Published: September 2010

Modulation of transforming growth factor‐β (TGF‐β) signaling to promote muscle growth holds tremendous promise for the muscular dystrophies and other disorders involving the loss of functional muscle mass. Previous studies have focused on the TGF‐β family member myostatin and demonstrated that inhibition of myostatin leads to muscle growth in normal and dystrophic mice. We describe a unique method of systemic inhibition of activin IIB receptor signaling via adeno‐associated virus (AAV)‐mediated gene transfer of a soluble form of the extracellular domain of the activin IIB receptor to the liver. Treatment of mdx mice with activin IIB receptor blockade led to increased skeletal muscle mass, increased force production in the extensor digitorum longus (EDL), and reduced serum creatine kinase. No effect on heart mass or function was observed. Our results indicate that activin IIB receptor blockade represents a novel and effective therapeutic strategy for the muscular dystrophies. Muscle Nerve, 2010
Die Novelle Zweiter Teil: Das Altstoffproblem
Authors: Sailer Christian
Published: September 2010

„Mitteilungspflichten bei alten Stoffen”︁ soll der neugefaßte § 16 d der Novelle zum Chemikaliengesetz regeln. Ziel: Weg von der Feuerwehrfunktion, hin zu langfristiger Gefahrenvorsorge.
Sustainable Development
Authors: Hauthal H.G.
Published: September 2010

Die chemische Industrie bekennt sich als Ganzes zu einer nachhaltigen, zukunftsverträglichen Entwicklung. Mit dem Positionspapier des VCI geht es vor allem darum, ökonomische, ökologische und gesellschafliche Zielsetzungen gleichrangig anzustreben.
Spartan in neuer Umgebung
Authors: Brunberg Ingo , Fels Gregor
Published: September 2010

Mit PC Spartan Pro hat die Firma Wavefunction nun beinahe den gesamten Funktionalitätsumfang des Unix‐basierten Molecular‐Modeling‐Klassikers Spartan auf Windows/Intel‐Plattformen portiert. Nimmt man zusätzlich noch einen Rechner der neuen Silicon‐Graphics(SGI)‐Computergeneration, eine Visual Workstation, so kann auch die graphische Ausgabe der Moleküldarstellungen mit den Unixmaschinen gut mithalten. Aber lohnt sich für den Hobbymodellierer die Anschaffung der relativ teuren NT‐Workstation für das Arbeiten mit dem vergleichsweise preiswerten PC Spartan Pro?
Effects of S‐citalopram, citalopram, and R‐citalopram on the firing patterns of dopamine neurons in the ventral tegmental area,N‐methyl‐D‐aspartate receptor‐mediated transmission in the medial prefrontal cortex and cognitive function in the rat
Authors: Schilström Björn , Konradsson‐Geuken Åsa , Ivanov Vladimir , Gertow Jens , Feltmann Kristin , Marcus Monica M. , Jardemark Kent , Svensson Torgny H.
Published: September 2010

Escitalopram, the S‐enantiomer of citalopram, possesses superior efficacy compared to other selective serotonin reuptake inhibitors (SSRIs) in the treatment of major depression. Escitalopram binds to an allosteric site on the serotonin transporter, which further enhances the blockade of serotonin reuptake, whereas R‐citalopram antagonizes this positive allosteric modulation. Escitalopram's effects on neurotransmitters other than serotonin, for example, dopamine and glutamate, are not well studied. Therefore, we here studied the effects of escitalopram, citalopram, and R‐citalopram on dopamine cell firing in the ventral tegmental area, using single‐cell recordingin vivoand on NMDA receptor‐mediated currents in pyramidal neurons in the medial prefrontal cortex usingin vitroelectrophysiology in rats. The cognitive effects of escitalopram and citalopram were also compared using the novel object recognition test. Escitalopram (40–640 μg/kg i.v.) increased both firing rate and burst firing of dopaminergic neurons, whereas citalopram (80–1280 μg/kg) had no effect on firing rate and only increased burst firing at high dosage. R‐citalopram (40–640 μg/kg) had no significant effects. R‐citalopram (320 μg/kg) antagonized the effects of escitalopram (320 μg/kg). A very low concentration of escitalopram (5 nM), but not citalopram (10 nM) or R‐citalopram (5 nM), potentiated NMDA‐induced currents in pyramidal neurons. Escitalopram's effect was antagonized by R‐citalopram and blocked by the dopamine D1receptor antagonist SCH23390. Escitalopram, but not citalopram, improved recognition memory. Our data suggest that the excitatory effect of escitalopram on dopaminergic and NMDA receptor‐mediated neurotransmission may have bearing on its cognitive‐enhancing effect and superior efficacy compared to other SSRIs in major depression. Synapse, 2010. © 2010 Wiley‐Liss, Inc.
Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self‐administration
Authors: Norman Andrew B. , Norman Mantana K. , Tabet Michael R. , Tsibulsky Vladimir L. , Pesce Amadeo J.
Published: September 2010

Competitive dopamine receptor antagonists increase the rate of cocaine self‐administration. As the rate of self‐administration at a particular unit dose is determined by the satiety threshold and the elimination half‐life (t1/2) of cocaine, we investigated whether dopamine receptor antagonists altered these parameters in rats. The plasma cocaine concentration at the time of each self‐administration was constant during a session demonstrating that this satiety threshold concentration represents an equiactive cocaine concentration. The plasma cocaine concentration at the time of self‐administration was increased by SCH23390, consistent with pharmacological theory. In rats trained to reliably self‐administer cocaine, SCH23390 had no effect on the plasma steady‐state cocaine concentration produced by constant infusions of cocaine. Therefore, this antagonist had no effect on cocainet1/2at a dose that accelerated cocaine self‐administration. A constant cocaine infusion at a rate that maintained steady state concentrations above the satiety threshold stopped self‐administration. SCH23390, or the D2dopamine receptor antagonist (−)eticlopride, reinstated self‐administration in the presence of the constant cocaine infusion. This is consistent with SCH23390 and eticlopride raising the satiety threshold above the steady state level produced by the constant cocaine infusion. It is concluded that the antagonist‐induced acceleration of cocaine self‐administration is the result of a pharmacokinetic/pharmacodynamic interaction whereby the rate of cocaine elimination is faster at the higher concentrations, as dictated by first‐order kinetics, so that cocaine levels decline more rapidly to the elevated satiety threshold. This results in the decreased interinjection intervals. Synapse, 2010. © 2010 Wiley‐Liss, Inc.
FSH isoform pattern in classic galactosemia
Authors: Gubbels Cynthia S. , Thomas Chris M. G. , Wodzig Will K. W. H. , Olthaar André J. , Jaeken Jaak , Sweep Fred C. G. J. , Rubio‐Gozalbo M. Estela
Published: September 2010

Female classic galactosemia patients suffer from primary ovarian insufficiency (POI). The cause for this long‐term complication is not fully understood. One of the proposed mechanisms is that hypoglycosylation of complex molecules, a known secondary phenomenon of galactosemia, leads to FSH dysfunction. An earlier study showed less acidic isoforms of FSH in serum samples of two classic galactosemia patients compared to controls, indicating hypoglycosylation. In this study, FSH isoform patterns of five classic galactosemia patients with POI were compared to the pattern obtained in two patients with a primary glycosylation disorder (phosphomannomutase‐2‐deficient congenital disorders of glycosylation, PMM2‐CDG) and POI, and in five postmenopausal women as controls. We used FPLC chromatofocussing with measurement of FSH concentration per fraction, and discovered that there were no significant differences between galactosemia patients, PMM2‐CDG patients and postmenopausal controls. Our results do not support that FSH dysfunction due to a less acidic isoform pattern because of hypoglycosylation is a key mechanism of POI in this disease.
The role of religious involvement on depression, risky behavior, and academic performance among Korean American adolescents
Authors: Kang Piljoo P. , Romo Laura F.
Published: September 2010

Structural equation modeling was used to test a theoretical path model of church engagement, personal spirituality, and mentoring relationships on depressive symptoms, involvement in risky behaviors, and self‐reported grades among Korean American adolescents. It was hypothesized that personal spirituality and mentoring relationship quality would mediate the relation between church engagement and adolescent outcomes. Data were obtained through a self‐report survey from 248 Korean American adolescents in grades 7 through 12. High levels of church engagement, as characterized by years of attendance, choice to attend, and participation in activities, predicted deeper personal spirituality and better mentoring relationships. Personal spirituality, as measured by one's daily religious experiences, beliefs, and private spiritual practices, was a mediator of the relationship between church engagement and adolescent outcomes. Specifically, higher levels of church engagement was linked to stronger personal spirituality, which in turn predicted less depressive symptoms for girls and higher grades for boys.
Reducing Surgical Site Infections by Bundling Multiple Risk Reduction Strategies and Active Surveillance
Authors: Lipke Virginia Leigh , Hyott Anthony S.
Published: September 2010

Postoperative surgical site infections (SSIs) are serious health care‐associated infections that contribute to higher rates of mortality. Methicillin‐resistant Staphylococcus aureus (MRSA) is an increasingly common cause of SSIs. A quality improvement intervention was developed to identify surgical patients with nasal colonization of MRSA, treat them with mupirocin, and introduce a new preoperative skin antisepsis protocol using 2% chlorhexidine gluconate cloths. The total number of SSIs was reduced by 63%, and MRSA SSIs decreased by 78%. Preoperative MRSA screening and treatment and the preoperative skin antisepsis protocol were smoothly integrated into the facility workflow and well accepted by patients. This intervention saved two community hospitals an estimated $240,000.
Clinical Issues—September 2010
Authors: Ogg Mary
Published: September 2010

This Month

Safe perioperative use of glutaraldehyde

Key words: high‐level disinfection, glutaraldehyde, disinfectant, glutaraldehyde‐based products, adverse effects, low‐level disinfection, chemical disinfection, liquid sterilant.

Safe patient handling and movement in the perioperative setting

Key words: ergonomics, prepping, patient handling.

Thermal burns during phacoemulsification

Key words: corneal burns, thermal burns, phacoemulsification, cataract surgery.

Wearing surgical masks while administering a spinal anesthetic

Key words: surgical mask, spinal anesthetic, anesthesia care provider, aseptic technique.
Planning Locally Relevant Internet Programs for Secondary Prevention of Cardiovascular Disease
Authors: Neubeck Lis , Ascanio Rhoda , Bauman Adrian , Briffa Tom , Clark Alexander M. , Freedman Ben , Redfern Julie
Published: September 2010

Background: Although the Internet has been shown to be an effective tool for supporting behavioural change in other chronic diseases, less in known about the efficacy of, or need for, Internet-based interventions in the prevention of coronary heart disease (CHD).

Aims: We investigated computer literacy, consumer need and perceived usefulness of the Internet as a secondary prevention tool in people with CHD.

Methods: A two-step mixed-method process was used that included a survey and two focus groups. The 12-item survey explored participants' access and confidence using the Internet. For the focus groups, we used standard methodology.

Results: We recruited 66 (88% response rate) consecutive cardiac patients; age 36–73 years (mean 64±13), mostly male (85%), whose primary language was predominantly English (67%). Seventy percent had a home computer with Internet access but only 20% reported researching their heart-health online. There was polarity between those with and without Internet access. Further, we found less women than men could complete online forms (p=0.03) and that participants aged over 65 years were less likely to access the Internet (p<0.01) and had lower confidence (p<0.01) than younger counterparts. Focus groups revealed challenges of an online secondary prevention service, but participants valued relevant, practical advice and placed strong emphasis on simple web design.

Conclusion: Using a mixed-methods process we collected locally sensitive information about Internet usage and recommendations for future online health-management strategies. Some patients have more confidence using the Internet, therefore a range of multi-technological secondary prevention interventions should be considered based on individual need.
Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates
Authors: Chu Hsing-Mao , Chen Feng-Yuan , Ko Tzu-Ping , Wang Andrew H.-J.
Published: September 2010

Various plant developmental processes involve phytohormones such as cytokinins. Isopentenyltransferase (IPT) reaction is the key rate‐limiting step in cytokinin biosynthesis that transfers the isopentenyl (iP) group from dimethylallyl diphosphate to the N6‐amino group of adenine. Here, a series of diadenosine polyphosphates (Ap
n
A) were screened as possible substrates of IPT, among which diadenosine tetraphosphate, diadenosine pentaphosphate and diadenosine hexaphosphate showed higher affinity than did the authentic substrates ADP and ATP. In addition, formation of mono‐isopentenyl Ap
n
A and di‐isopentenyl Ap
n
A was observed. Judging by the existing biosynthetic and hydrolytic systems for Ap
n
A in plants, Ap
n
A and isopentenyl‐Ap
n
A may occur in the plant cells, with functional importance.
Sequence of magmatic events in the Late Paleozoic of Transbaikalia, Russia (U-Pb isotope data)
Authors: Tsygankov A.A. , Litvinovsky B.A. , Jahn B.M. , Reichow M.K. , Liu D.Y. , Larionov A.N. , Presnyakov S.L. , Lepekhina Ye.N. , Sergeev S.A.
Published: September 2010

The Late Paleozoic intrusive rocks, mostly granitoids, totally occupy more than 200,000 km2 on the territory of Transbaikalia. Isotopic U-Pb zircon dating (about 30 samples from the most typical plutons) shows that the Late Paleozoic magmatic cycle lasted for 55–60 m.y., from ~330 Ma to ~275 Ma. During this time span, five intrusive suites were emplaced throughout the region. The earliest are high-K calc-alkaline granites (330–310 Ma) making up the Angara–Vitim batholith of 150,000 km2 in area. At later stages, formation of geochemically distinct intrusive suites occurred with total or partial overlap in time. In the interval of 305–285 Ma two suites were emplaced: calc-alkaline granitoids with decreased SiO2 content (the Chivyrkui suite of quartz monzonite and granodiorite) and the Zaza suite comprising transitional from calc-alkaline to alkaline granite and quartz syenite. At the next stage, in the interval of 285–278 Ma the shoshonitic Low Selenga suite made up of monzonite, syenite and alkali rich microgabbro was formed; this suite was followed, with significant overlap in time (281–276 Ma), by emplacement of Early Kunalei suite of alkaline (alkali feldspar) and peralkaline syenite and granite. Concurrent emplacement of distinct plutonic suites suggests simultaneous magma generation at different depth and, possibly, from different sources. Despite complex sequence of formation of Late Paleozoic intrusive suites, a general trend from high-K calc-alkaline to alkaline and peralkaline granitoids, is clearly recognized. New data on the isotopic U-Pb zircon age support the Rb-Sr isotope data suggesting that emplacement of large volumes of peralkaline and alkaline (alkali feldspar) syenites and granites occurred in two separate stages: Early Permian (281–278 Ma) and Late Triassic (230–210 Ma). Large volumes and specific compositions of granitoids suggest that the Late Paleozoic magmatism in Transbaikalia occurred successively in the post-collisional (330–310 Ma), transitional (305–285 Ma) and intraplate (285–275 Ma) setting.
Permo-Triassic plume magmatism of the Kuznetsk Basin, Central Asia: geology, geochronology, and geochemistry
Authors: Buslov M.M. , Safonova I.Yu. , Fedoseev G.S. , Reichow M.K. , Davies K. , Babin G.A.
Published: September 2010

The Kuznetsk Basin is located in the northern part of the Altai–Sayan Folded Area (ASFA), southwestern Siberia. Its Late Permian–Middle Triassic section includes basaltic stratum-like bodies, sills, formed at 250–248 Ma. The basalts are medium-high-Ti tholeiites enriched in La. Compositionally they are close to the Early Triassic basalts of the Syverma Formation in the Siberian Flood basalt large igneous province, basalts of the Urengoi Rift in the West Siberian Basin and to the Triassic basalts of the North-Mongolian rift system. The basalts probably formed in relation to mantle plume activity: they are enriched in light rare-earth elements (LREE; Lan = 90–115, La/Smn = 2.4–2.6) but relatively depleted in Nb (Nb/LaPM = 0.34–0.48). Low to medium differentiation of heavy rare-earth elements (HREE; Gd/Ybn = 1.4–1.7) suggests a spinel facies mantle source for basaltic melts. Our obtained data on the composition and age of the Kuznetsk basalts support the previous idea about their genetic and structural links with the Permian–Triassic continental flood basalts of the Siberian Platform (Siberian Traps) possibly related to the activity of the Siberian superplume which peaked at 252–248 Ma. The abruptly changing thickness of the Kuznetsk Late Permian–Middle Triassic units suggests their formation within an extensional regime similar to the exposed rifts of Southern Urals and northern Mongolia and buried rifts of the West Siberian Basin.
Slavic Prosody
Authors: Bethin Christina Y.
Published: September 2010

In Slavic Prosody, first published in 1998, Professor Bethin gives a coherent account of the Slavic languages at the time of their differentiation and relates these developments to issues in phonological theory. First Professor Bethin argues that the syllable structure of Slavic changed before the fall of the jers and suggests that intrasyllabic and intersyllabic reorganization in Late Common Slavic was far more significant for Slavic prosody than the loss of weak jers. She then makes a case for the existence of a bisyllabic prosodic domain in Late Common Slavic and trochaic metrical organization. Finally, she explores the implications of Slavic data for phonological theory, discussing sonority, skeletal structure, the representation of length and prominence, and language typology in some detail.
The effect of giving 11 or 14 feeds of milk substitute per week to early-weaned calves
Authors: Boucque Ch. V. , Buysse F. X. , Cottyn B. G.
Published: September 2010

Two rearing experiments were carried out to study the effect of omitting three feeds per week from an early-weaning system on the performance of 110 male calves. From the third week the calves in the experimental groups received only one feed of milk substitute on Saturdays, at 11.00 hr; on Sundays they received no milk substitute at all; from Monday to Friday they were fed twice daily. The animals in the control groups received milk substitute twice daily during the 7 days of the week, quantity per feed being the same as for the experimental groups.

The calves were weaned at 8 weeks in experiment 1 and at 5 weeks in experiment 2.

In both experiments the calves in the control group had a significantly higher daily gain than the experimental calves during the third to the fifth weeks. From 6 to 16 weeks arid for the experiment as a whole no significant difference in weight gain or feed intake were observed. The omission of three feeds per week offered considerable advantages in the saving of labour and convenience of management.
Natural and induced ovulation rate of Finnish Landrace and other breeds of sheep
Authors: Bradford G. E. , Quirke J. F. , Hart R.
Published: September 2010

Ewes of seven breeds (Oxford Down, Border Leicester, Finnish Landrace, Southdown, Welsh Mountain, Tasmanian Merino and Soay) were treated with progestagen-treated sponges to synchronize oestrus for an egg-transfer experiment. Ewes of five of the breeds were treated with superovulating doses of pregnant mare serum gonadotropin (PMSG). Mean body weight ranged from 89 kg for Oxford Downs to 20 kg for Soays. Interval from sponge withdrawal to oestrus differed significantly between breeds, ranging from 1·83 days in Finnish Landrace to 3·00 days for Soays, but was not consistently related to ewe weight. Treatment with PMSG prior to sponge removal reduced the interval to oestrus; fertilization rate at the first synchronized oestrus was low. There were marked differences among breeds in proportion of ewes showing oestrus following PMSG treatment, total follicular response, and proportion of follicles ovulated. Ewes of the Finnish Landrace breed, with the highest natural fertility, were equal or superior to the other breeds in every component of response, and yielded more than double the number of fertilized eggs per ewe of the next best breed. Finnish Landrace females 6 to 9 months old made very satisfactory donors. Natural ovulation rates of adult recipient ewes were as follows: Welsh Mountain (23 ewes)—1·43; Border Leicester (15 ewes)—2·00; Finnish Landrace (26 ewes)—3·31.