bluuebunny/crossref_metadata_2025 huggingface dataset:
UMS 8 Kapsamında Maddi Duran Varlıklardaki Değişimlerin Muhasebeleştirilmesi
Authors: BÜYÜKARIKAN Ulukan , YILDIRIM Adem , ERYILMAZ Cengiz
Published: December 2023

İşletmelerin uyguladığı amortisman politikaları finansal performansı önemli ölçüde etkilemektedir. Bu etkiyi ortaya koyabilmek için amortismanın belirlenmesinde yer alan; yöntem, süre ve elden çıkarma gibi önemli değişkenleri göz önünde bulundurmak gerekmektedir. UMS 8 Uluslararası Muhasebe Standartlarının uygulama sürecindeki tahmin ya da politikalardaki değişikliklerin ve hataların düzeltilmesine ilişkin muhasebeleştirme ve açıklama esasları düzenlemektedir. Bu esaslar bağlamında işletmelerin uyguladığı amortisman politikalarında yer alan; yöntem, süre ve elden çıkarma gibi önemli değişkenlerin finansal bilgilerde meydana gelen etkilerini göstermek çalışmanın temel amacını oluşturmaktadır. Çalışmada kısıt olarak maddi duran varlıklardaki değişimlerin muhasebeleştirilmesi esas alınmıştır. Bu kapsamda UMS 8 açısından Maddi Duran Varlıklardaki Değişimlerin Muhasebeleştirilmesindeki tebliğlere ilişkin örnekler çalışmada yer almıştır. İşletmelerin duran varlıklarda bakım, onarım ve iyileştirme politikası amortisman süresini uzatılabilir, tahmin edilenden daha fazla ya da piyasa koşullarındaki değişimlerin etkisiyle daha düşük bir performans ortaya konulabilir. Amortisman süresinin değiştirilmesi, muhasebe değerlendirmesinde değişime neden olmakta ve değerlendirme UMS 8'e göre muhasebeleştirilmektedir. Bu bağlamda muhasebe politikalarındaki değişimin finansal etkilerinin dipnotlarda belirtilmesi gerekmektedir. Ayrıca tahminlerde meydana gelen değişimlerle birlikte varlık, borç ve özkaynak kalemlerindeki değişimlerin etkileri, gelecek dönemlerdeki kâr veya zararla ilişkilendirilerek finansal tablolarda gösterilmelidir.

Maddi duran varlıklara ilişkin değerleme politikalarında değişiklik yapıldığında bu durum “politika değişikliği” olarak kabul edilmedir. UFRS 13’e göre Geriye dönük uygulama, “maliyet modelinden yeniden değerleme modeline geçiş”te politika değişikliğine uygulanmamaktadır. Yeniden değerleme modelinden maliyet modeline geçişte yine “politika değişikliği” kabul edilmekte ve “geriye dönük uygulama” yapılarak yapılması gerekir.
Upaya Meningkatkan Kompetensi Profesional Guru SDN Andongsili Kecamatan Mojotengah Kabupaten Wonosobo melalui Coaching Model GROW Tahun Ajaran 2023/2024
Authors: Suparna Suparna
Published: December 2023

Professional competence is one of the 4 important competencies that teachers must master. However, in reality, the professional competence of teachers is still lacking. This is the case for teachers at Andongsili primary school, Mojotengah sub-district, Wonosobo district. Teachers have not been able to improvise their own syllabus. Teachers still use the syllabus taken from the KKG results. Teachers who have implemented classroom action research usually only do it for their final assignment, while problems that occur in the classroom are usually only solved through discussions with the principal or colleagues. Teachers have not optimally utilized the development of technology and communication. For example, in making learning media and interactive modules, teachers have also not done reflection actions optimally after each lesson. This study aims to improve teachers' professional competence through GROW model coaching for teachers at SD Negeri Andongsili, Mojotengah District, Wonosobo Regency. This type of research is school action research (PTS), while the approach uses a quantitative approach. This research was conducted at Andongsili State Elementary School, Mojotengah District, Wonosobo Regency. The research subjects were teachers at SD Negeri Andongsili, Mojotengah District, Wonosobo Regency consisting of 7 teachers. The object of this research is teachers' professional competence. The research was conducted in two cycles consisting of three competencies each cycle, namely planning, implementation, and reflection. This research was conducted collaboratively between researchers and teachers at SD Negeri Andongsili, Mojotengah District, Wonosobo Regency. The data collection instruments used were test results and documentation. The results of this study indicate that the application of the GROW Coaching model can improve the professional competence of teachers at Andongsili State Elementary School, Mojotengah District, Wonosobo Regency The increase is shown from the average score of the pre tes and posttest to cycle II. Pre tes cycle I, the average score obtained was 74.28. The score increased in cycle II, which was 84.29. There was an increase of 10.01 points. In addition to the increase in pre tes, the pos tes score also increased. The pos tes score in cycle I obtained an average of 87.86, while cycle II increased to 92.86. In other words, there was an increase of 5 points. Because 100% of Andongsili teachers, Mojotengah District, Wonosobo Regency have managed to meet the KKM, this research is said to be successful.
Keywords: Coaching, school action research, competence
O palácio de D. Gastão, no sítio do Grilo
Authors: Monteiro Patrícia
Published: December 2023

Located between Xabregas and Grilo, in the Eastern part of Lisbon, the palace of D. Gastão goes unnoticed by the city’s inhabitants. The building belonged to an architectural morphology typical of the riverbank, with a main façade facing the Tagus river, of which not many examples have been preserved. The shoreline from Santa Apolónia to Poço do Bispo has been dramatically transformed as a result of the major changes brought about in the urban east by the construction of factories and workers’ neighbourhoods, the railroads, and, most importantly, the Tagus embankment. Nevertheless, many palaces from the 17th and 18th centuries still stand along this path, hidden from view, among abandoned warehouses and industrial wreckage. The building mentioned in this text is a classic example of this circumstance. After losing its river connection and suffering the effects of industrialization, the building’s fate remains unknown as part of the principle of urban regeneration that has swept over the city’s eastern outskirts since the end of the twentieth century.
O percurso do Abjecionismo no discurso crítico de Mário Cesariny
Authors: Sousa Rui
Published: December 2023

Abjectionism has been one of the most debated strands related to the course of the Surrealist movement in Portugal. This text proposes a synthetic perspective of the main aspects evoked by this concept and presents an overview of some representative stages of Mário Cesariny’s critical thinking, in which the poet proposes different interpretations of Abjectionism. In Cesariny, Abjectionism was initially seen as a significant component of the plural Surrealist manifestation in Portugal, progressively coming to be seen, on the one hand, as an expression of a conjuncture shared by authors from different literary and artistic currents, on the other hand as a path unrelated to Surrealism and abusively appropriated by Luiz Pacheco.
A Matemática em Mário-Henrique Leiria
Authors: Freitas Pedro , Martuscelli Tania
Published: December 2023

The complete works of Mário-Henrique Leiria were published in recent years (2017-2022) by E-Primatur, curated by Tania Martuscelli and edited by Hugo Xavier. Knowing already of the existence of some mathematical elements in the work of this author, this occasion became, therefore, a particularly favorable one to make a complete collection of these occurrences, in order to understand in what ways and in what terms Leiria understood the interweaving of Mathematics with his textual and graphic production activity. This is the subject we propose to treat in this article.
Surrealismo, poesia e visualidade: Pelo universo das contra-imagens
Authors: Santos Ana Isabel
Published: December 2023

Taking as a starting point the work of two precursors of the Surrealist revolution in Portugal in the 1940’s and 1950’s, this essay will engage in a metacritical commentary around the debate on literary and artistic experimentations that break with outdated models, eliminate the dissipation of the distance between lyric, narrative and plasticity by means of medial combination, and instabilize the traditional dynamics of aesthetic reception. The problematization of the dialogue between poetry and visual narrative allows us to perform a reading of hybrid works under the light of theories from the field of Literary Studies and Intermediality, applied here directly to the productions of Mário Cesariny (1923-2006) and Mário-Henrique Leiria (1923-1980), whose centenaries are celebrated in 2023.
Para bem esclarecer as gentes que ainda estão à espera: Mário-Henrique Leiria não teve filhos, mas tem herdeira!
Authors: Martuscelli Tania
Published: December 2023

Text attached to the thematic dossier.
«”já não há culpados[,] apenas condenados” — Expressões literárias de epidemias globais
Authors: Araújo Sofia de Melo
Published: December 2023

Epi- and pandemic outbreaks hitting Humanity are carved into Human History in such a painful way that it allows for the easy chronological outlining of their (rarely abundant) literary expression, but also for a heightened sense of their continuous indirect effect on literature and culture. This study strives to present a critical panorama of the way in which such public health phenomena have been read and/or have fueled literary imagination throughout History, in Portugal and elsewhere.
Analisis Pengaruh Electroni Word of Mouth and Perceived Risk terhadap Keputusan Pembelian Konsumen Shopee
Authors: Noor Lorine Kalista , Ramayanti Nur Endah , Sartika Dewi
Published: December 2023

Penelitian ini termasuk dalam kategori penelitian eksplanatori dan menggunakan metode pengambilan sampel nonprobabilitas dengan teknik purposive. Tujuan dari penelitian ini adalah untuk mengevaluasi bagaimana electronic word of mouth (e-WOM) dan risiko yang dirasakan memengaruhi keputusan pembelian di Shopee. Studi ini melibatkan 100 responden, yang semuanya adalah konsumen Shopee; analisis dilakukan menggunakan IBM SPSS 21.0. Temuan menunjukkan bahwa e-WOM memainkan peran dalam memengaruhi keputusan pembelian, berkontribusi sebesar 24.4%, dengan faktor-faktor lain yang mempengaruhi keputusan di luar e-WOM. Demikian pula, risiko yang dirasakan berdampak pada keputusan pembelian, berkontribusi sebesar 26.8%, sementara faktor-faktor lain juga mempengaruhi keputusan. Ketika e-WOM dan risiko yang dirasakan dipertimbangkan secara bersamaan, keduanya berkontribusi sebesar 33.3% terhadap keputusan pembelian, dengan faktor lain menjelaskan sisanya. Uji F menunjukkan bahwa e-WOM dan risiko yang dirasakan memiliki pengaruh yang signifikan terhadap keputusan pembelian. Pada dasarnya, e-WOM yang positif dan risiko yang dirasakan yang rendah menyebabkan keputusan pembelian yang lebih tinggi di Shopee. Hasil ini menunjukkan bahwa Shopee harus mendorong pelanggan untuk memberikan ulasan yang lengkap dan jelas dengan poin insentif. Selain itu, Shopee harus berkonsentrasi pada meningkatkan layanan dan mendidik pelanggan tentang mekanisme transaksi.
The association between atherogenic index of plasma and stroke in Chinese middle-aged and elderly population: a national cross-sectional study
Authors: Xu Feifei , Zhong Xi
Published: December 2023

Objective: To investigate the association between atherogenic index of plasma (AIP) and stroke.
Methods: The 2015 China Health and Retirement Longitudinal Study (CHARLS) survey was used in this study. Logistic regression was adopted to examine the relationship between AIP, calculated as log (TG/HDL), and stroke. Subgroup analysis was used to further explore the associated factors. Restricted cubic spline (RCS) regression was adopted to estimate the non-linear association. Receiver operator characteristic (ROC) analysis was utilized to calculate the cutoff value of AIP.
Results: In this study, 13,027 participants aged 45 years above were enrolled. The odds ratios in the fully adjusted logistic model across the quartiles of AIP were 1.00 (reference), 1.09 (95% CI 0.69–1.72), 1.62 (95% CI 1.06–2.49), 1.07 (1.08–2.58), respectively. Non-linear association between AIP and stroke was not found using RCS regression (p for non-linearity > 0.05). The subgroup analyses showed that the association between AIP and stroke varied in different gender, alcohol and cigarette consumption, but the interaction effects were insignificant (all p > 0.05). The cutoff value of AIP was 0.82, and the area under the curve (AUC) was 0.57.
Conclusion: Elevated AIP is significantly associated with the increased risk of stroke in the middle- aged and elderly Chinese, indicating that AIP may be a predictive factor for stroke among the Chinese middle-aged and elderly.
Phenotypic comparison of a novel variant (p.P164R) and A founder mutation (c.748+1G>A) in Warburg Micro syndrome
Authors: Cinleti Tayfun , Sarıkaya Uzan Gamze , Bürçe Büşra , Küçümen Yağmur , Yalçın Hatice Yelda , Gürsoy Semra , Yiş Uluç , Çağlayan Ahmet Okay , Giray Bozkaya Özlem
Published: December 2023

Warburg Micro syndrome is a rare autosomal recessive disease due to pathogenic variants found most commonly in the RAB3GAP1 gene. It is commonly seen in consanguineous marriages and is characterized by optic, neurologic, endocrinologic and some non-typical findings (cardiomyopathy, peripheral neuropathy). Here, we report two male patients from healthy consanguineous and non- consanguineous carrier parents, with homozygous variants of the RAB3GAP1 gene, presenting with bilateral congenital cataracts, hypogonadism, hypotonia and developmental delay. The first case had a novel variant and had colpocephaly as shown in his MRI brain, which has not been previously reported in the medical literature. The second case was thought to have a founder mutation for Turkey. In conclusion, there was no phenotypical difference between the novel and founder mutations. In Turkish patients suspected to have Warburg Micro syndrome, we recommend molecular testing for the detection of a founder mutation.
Construction and validation of a nomogram model to predict symptomatic intracranial hemorrhage after intravenous thrombolysis in elderly population with severe white matter lesions
Authors: Nie Qiurui , Shen Yu , Deng Zhisheng , Xiang Wenwen , Chen Shenjian , Li Guangmin
Published: December 2023

Background and Objective: Elderly people are at high prevalence of atherosclerotic cerebral infarction. Cerebral white matter lesions (WMLs) increase the risk of bleeding after intravenous thrombolysis (IVT) although they may also require the IVT. The aim of this study is to develop a clinical nomogram model for post-IVT symptomatic intracranial hemorrhage (sICH), with the aim to prevent sICH in elderly patients with severe WMLs when IVT is being considered.
Methods: This is a large single-center retrospective analysis study of elderly patients with severe WMLs receiving IVT from January 2018 to December 2022. Univariate and multi-factor logistic regression analysis were used to construct nomogram model, and a series of validations were performed on the model.
Results: More than 2,000 patients with IVT were screened for inclusion in this study after cranial magnetic resonance imaging evaluation. Out of these, 163 elderly patients had cerebral WMLs, and 25 had sICH. In univariate analysis, history of hypertension (p=0.037), hyperlipidemia (p<0.001), NIHSS score before IVT (p<0.001), low-density lipoprotein levels (p=0.016), cholesterol levels (p=0.020), platelet count (p=0.006), systolic blood pressure (p<0.001), diastolic blood pressure (p<0.001) were significantly associated with sICH. In a multifactorial analysis, the NIHSS score before IVT (OR 42.056 CI 7.308-242.012, p<0.001), and diastolic blood pressure (OR 1.050 CI 1.002-1.100, p=0.040) were found to be significantly associated with sICH after IVT. The four most significant risk factors from logistic regression are subsequently fitted to create a predictive model. The accuracy was verified using calibration curves, decision curves, and clinical impact curves, and the model was considered to have strong stability.
Conclusions: The NHISS score before IVT and diastolic blood pressure are independent risk factors for sICH after IVT in elderly patients with severe WMLs. The models are highly accurate and can be applied clinically to provide a reliable predictive basis for IVT in elderly patients with severe WMLs.
Relationship of personality traits with stigmatization, depression, and quality of life in patients with multiple sclerosis
Authors: Yeni Kubra , Terzi Murat
Published: December 2023

Background & Objective: Personality traits are associated with mental health and quality of life in patients with multiple sclerosis (MS). The aim of this study was to determine personality traits in patients with MS and to examine the relationship between these traits and stigmatization, depression and quality of life.
Method: This descriptive, cross-sectional study included 80 MS patients and 96 healthy controls. Data were collected online between June and July 2022. Patient/person information form, Eysenck Personality Questionnaire Revised-Short Form (EPQ-RS), Neuro Quality of Life-Stigma Scale, Beck Depression Inventory and MS Quality of Life Scale-54 were used for data collection.
Results: When the age variable was controlled, it was found that the mean neuroticism subscale score was higher (p=0.003) and the mean extraversion subscale score was lower (p=0.018) than the control group. In addition, the mean extraversion score was found to be negatively correlated with stigmatization (p<0.05) and depression (p<0.01), and positively correlated with the physical sub-dimension of quality of life (p<0.01). Neuroticism and psychoticism sub-dimensions were positively correlated with stigmatization and depression and negatively correlated with all sub-dimensions of quality of life (p<0.01). In addition, regression analysis showed that depression significantly contributed to the physical health dimension of quality of life and neuroticism personality trait significantly contributed to the mental health dimension.
Conclusions: Neurotic personality traits were found to be more dominant in patients with MS. Moreover, all sub-dimensions of personality traits were associated with stigmatization, depression and quality of life. Therefore, personality traits should be considered in interventions to improve mental health and quality of life.
Modifiable risk factors for dementia in Indonesia: Results from STRiDE project
Authors: FITRI FASIHAH IRFANI , Farina Nicolas , Turana Yuda , Theresia Imelda , Sani Tara Puspitarini , Ika Suswanti  , Banerjee Sube
Published: December 2023

Background & Objective: Indonesia’s ageing population and increasing number of people living with dementia poses significant challenge to the health system. Better understanding of factors related to dementia prevalence is needed to mitigate risk, improve care, and ultimately reduce the incidence of dementia. In this study, we aimed to describe associations between potential risk factors and dementia in Indonesia.
Methods: A cross-sectional study, part of the Strengthening Responses to Dementia in Developing Countries (STRiDE) project, was conducted in two provinces in Indonesia, Jakarta and North Sumatra between September and December 2021. A total of 2,110 older adults and their informants completed questionnaires covering cognitive and functional status, socioeconomic, medical and lifestyle factors. Models for each potential modifiable risk factor were created and then adjusted by age, sex and literacy. Prevalence ratios (PRs) were calculated for each risk factor.
Results: In the adjusted models, lower education, lower occupational attainment, unmanaged diabetes, stroke, head trauma within the past 5 years, hearing loss, and chronic obstructive airway disease were all associated with higher prevalence of dementia in Indonesia. Current smoking, historic depression and high blood pressure were associated with higher dementia prevalence, but not statistically significant.
Conclusion: Improving socioeconomic status (i.e., education and employment) and reducing health- related risk factors may be viable solutions to reduce the high prevalence rates of dementia in Indonesia. Further longitudinal research is needed to confirm direction of effect and causality.
Intensive care unit admission prediction tool for ischemic stroke patients receiving intravenous thrombolysis: A retrospective cohort study
Authors: Tiyadechachai Chinarong , Vattanavanit Veerapong
Published: December 2023

Background: Some evidence suggests that given the limited healthcare resources, the majority of low- risk stroke patients may not require critical care monitoring. This study aimed to establish a predictive score for identifying post-intravenous thrombolysis (IVT) acute ischemic stroke patients who should be monitored in the intensive care unit (ICU).
Methods: This was a retrospective cohort study of patients with acute ischemic stroke who underwent IVT at Songklanagarind Hospital, Thailand between January 2010 and December 2019. Baseline characteristics and clinical outcomes were recorded. Systolic blood pressure (SBP) was collected using the first recorded in the emergency department (ED) as well as the National Institutes of Health Stroke Scale (NIHSS).
Results: Of the 171 patients with stroke, 73 (42.7%) needed ICU care. The median age was 67 years old. The median SBP and NIHSS were 160 mm Hg and 10, respectively. The predicting stroke ICU (PSU) score was developed, with the following points assigned: NIHSS score (1 point if > 9), SBP (1 point if > 170 mmHg), and infarct size greater than 1 lobe (2 points if present). The PSU score achieved an area under the ROC curve of 0.759 (95% confidence interval [CI] = 0.688–0.830). A PSU score ≥ 1 predicted the need for ICU care with a sensitivity of 91.78%.
Conclusions: The PSU score, which is based on the NIHSS score, systolic blood pressure, and infarct size, predicts the need for ICU care after IVT in patients with stroke.
Risk factors for peri-procedural stroke or death in internal carotid artery stenting: A neurology team experience
Authors: GÖRGÜLÜ ÜMİT , Recep Donmez  , Berna Arlı  , Gurdal Orhan
Published: December 2023

Background and Objectives: Suitable cases of extracranial internal carotid artery (ICA) stenosis can be treated with carotid artery stenting (CAS) or carotid endarterectomy. However, major complications in the peri-procedural period, like stroke and death, are more common with CAS. We therefore investigated the risk factors for stroke and death during the peri-procedural period following CAS.
Methods: In this study, the files of patients who were treated with CAS by a neurology team during 2020–2022 were retrospectively analyzed. Patient age, gender, vascular risk factors, use of antiplatelet therapy, type of carotid artery stenosis (symptomatic or asymptomatic), measured stenosis degrees, contralateral carotid stenosis, types of aortic arch, balloon angioplasty, use of a filter-type embolism protection device, stent cell design (open or closed), and peri-procedural death, stroke, or myocardial infarction (MI) were recorded. All patients were followed up for the first 30 days after CAS.
Results: The mean age of 219 patients included in our study was 67.8 ± 8.38 years and 68.5% were male. The most common comorbid diseases in the patients were hypertension (76.7%), hyperlipidemia (53.4%) and diabetes mellitus (DM) (43.4%). Stroke or death occurred in the peri-procedural period in 15 (6.85%) of the patients, but MI did not occur. No statistically significant difference was observed in terms of age or gender when comparing with the cases without stroke or death. Of the patients suffering stroke or death, ischemic stroke developed in 13 (86.67%), cerebral hemorrhage in two (13.33%) and two patients (13.33%) died. Two-thirds of the strokes were either minor (n=7, 46.67%) or moderate (n=4, 26.67%); 13 (86.67%) were ipsilateral, and 14 (93.33%) were in the anterior circulation. The complication risk was found to be significantly higher in patients with prior stroke (OR=3.865; 95% CI 1.282 to 11.652 p=.016), DM (OR=3.634; 95% CI 1.102 to 11.992 p=.034) and pre-dilation angioplasty (OR=13.100; 95% CI 1.762 to 97.422 p=.012).
Conclusion: Prior stroke, DM and pre-dilation angioplasty increase peri-procedural stroke and death in CAS. However, even if a stroke complication develops after CAS, it is often not severe.
Can eGFR be a prognostic factor for endovascular therapy for acute ischemic stroke?
Authors: ERCAN Zafer , BONCUK ULAŞ Sena , ACAR Bilgehan Atılgan , ACAR Türkan , DHEIR Hamad , GÜZEY ARAS Yeşim , İSLAM Mahmud , ERYILMAZ Alper , DALKILIÇ Şule , POLAT ZAFER Ayşe , UÇAROĞLU CAN Nimet
Published: December 2023

Background & Objective: Chronic kidney disease (CKD) is associated with increased mortality risk in acute stroke patients. This study aims to investigate potential association between CKD and the prognosis of endovascular treated acute ischemic stroke patients.
Methods: Patients with endovascular treatment (EVT) for acute ischemic stroke were studied retrospectively in a comprehensive stroke center. Patients were classified as pre-procedural CKD and non-CKD. The groups were compared regarding demographic data, procedural data, and outcomes.
Results: A total of 140 patients (69 male, 49.3%) with a mean age of 66.51±11.8 were involved in the study. Symptomatic intracranial hemorrhage in the first 24 hours and mortality in three months were increased in the CKD group (50% vs. 19.8; p=0.001). Excellent and good outcomes were decreased in the CKD group (25% vs. 53.4; p=0.01 and 41.6% vs. 56.9%; p=0.03). Multiple logistic regression adjusted for potential confounders demonstrated that CKD was associated with lower rates of excellent outcome (odds ratio [OR] = 0.50, 95% confidence interval [CI], 0.25 to 0.80, p = 0.01), higher mRS scores (common OR = 1.82, 95% CI, 1.2 to 2.9, p = 0.01), and increased mortality (OR = 2.1, 95% CI, 1.2 to 4.2, p = 0.01) and sICH (OR = 1.15, 95% CI, 1.03 to 3.4, P = 0.04)
Conclusion: There is an association between CKD and poorer results in patients with acute ischemic stroke treated with EVT. The presence of CKD should not prohibit patients from undergoing EVT, but taking baseline eGFR into account may improve estimation of prognosis and help decision-making in treatment modality.
Mitochondrial DNA 3252A>G mutation presenting as MERRF/MELAS overlapping syndrome: A case report
Authors: Tan Yin Yin , Tee Ting Yoong , Chew Farn Ye , Kok Huey Tean , Abd Rani Nor Haizura , Ngu Lock Hock , Viswanathan Shanthi
Published: December 2023

We report a case of 25 years old male presented with a complex phenotype of myoclonic epilepsy with ragged red fibers (MERRF) and mitochondrial encephalomyopathy, lactic acidosis and stroke- like episodes (MELAS) harbouring m.3252A>G mutation in the mitochondrially encoded tRNA leucine 1 (UUA/G) [MT-TL1] gene encoding the mitochondrial transfer ribonucleic acid (tRNA) for leucine. He presented with frequent myoclonus seizure, stroke-like episodes, elevated blood lactate with muscle biopsy showed numerous ragged-red fibers suggestive of a mitochondrial disorder. Whole mitochondrial genome sequencing revealed no mutations other than the A-to-G transition at nucleotide position 3252. This case report is the first to describe the m.3252A>G mutation in association with the MERRF/MELAS overlap syndrome.
Factors that impact health-related quality of life in 168 myasthenia gravis in West China: Disease severity, social support, and coping style
Authors: Miao Xiaohui , Chen Hongxi , Shi Ziyan
Published: December 2023

Background: Myasthenia gravis (MG) is associated with reduced health-related quality of life (HRQOL). This study aimed to investigate factors that impact HRQOL in MG in a patient population in West China.
Methods: A series of questionnaires were completed by 168 patients to assess the relationships between HRQOL and social support and coping style. We also evaluated the contributions of clinical characteristics to HRQOL. One-way analysis of variance (ANOVA), correlation and regression analysis were conducted to identify predictors that negatively impact HRQOL in MG.
Results: There were significant differences in HRQOL scores among patients with different ratio of disease cost to income each month (F = 5.831, P = 0.001) and frequency of MG symptoms (F = 9.128, P < 0.001). Spearman’s correlation analysis showed that reduced HRQOL had low correlation with Myasthenia Gravis Composite score (r = 0.461, P < 0.001), confrontation (r = 0.312, P < 0.001) and acceptance- resignation coping style (r = 0.433, P < 0.001). Stepwise regression analysis further revealed that acceptance-resignation coping style (β = 0.380, P < 0.001) and MGC score (β = 0.322, P < 0.001) were the main predictors of HRQOL.
Conclusions: Our study revealed the factors that impact HRQOL in MG patients and provided the first demonstration that acceptance-resignation is the main independent predictor of poor HRQOL in MG, other than disease severity.
The impact of COVID-19 on people with epilepsy is not over, a longitudinal study
Authors: Koh May Yi , Lim Kheng Seang , Fong Si Lei , Audrey Christine , Yu Xuen , Tan Chong Tin
Published: December 2023

Background: Despite the shift of the COVID-19 era, the post-pandemic impacts on healthcare for people with epilepsy (PWE) remain unknown. This study aimed to determine the clinical, logistic, and psychological impacts of the COVID-19 pandemic during and after COVID-19 containment measures.
Method: This is a longitudinal study over two years. Clinical and psychological outcomes of COVID-19 were assessed with the Hospital Anxiety Depression Scale (HADS) and Quality of Life in Epilepsy Inventory (QOLIE-31).
Result: A total of 239 patients were recruited, with a mean age of 38.32±14.16 years, and 51.5% were male. Seventy-nine (33.1%) were previously infected with COVID-19. As compared to during the COVID-19 pandemic, the percentage of patients who reported seizure worsening (13.0%) remained the same after the pandemic. The main reasons associated with seizure worsening include baseline seizure frequency ≥1 per month (54.8%), stress (61.3%) and fatigue (48.4%), despite more accessible clinic appointments (49.4%), medication supply (67.8%) and emergency units (62.8%). Psychologically, after the COVID-19 pandemic, PWE reported similar anxiety (4.65±4.46 vs. 4.78±3.72, p=0.715) and depression scores (3.81±3.97 vs. 3.86±3.52, p=0.869) than during the pandemic. Despite improvement in clinical and logistics factors, PWE experiences worsening in quality of life (57.44±15.41 vs. 61.70±15.05, p=<.001), especially in the emotional well-being, cognitive, medication effects, and social function subscales.
Conclusion: Despite the improvement in clinical and medication access in the post-COVID-19 era, the challenges and consequences of the pandemic remained, without an improvement in seizure control and psychological well-being, and worsening quality of life.
Evaluation of intracranial atherosclerotic disease risk factors in patients with acute ischemic stroke
Authors: Dinc Yasemin , OZPAR RIFAT , Mesut Gizem , Hojjati Farid , Hakyemez Bahattin , Bakar Mustafa
Published: December 2023

Background & Objective: Intracranial atherosclerotic disease (ICAD) is a prevalent cause of ischemic stroke and is related to recurrent strokes. In this study, we aim to identify the ICAD rate and establish the risk factors in patients with acute ischemic stroke (AIS) in our population in Turkey.
Methods: Eight hundred sixty-two patients diagnosed with AIS in our tertiary centre between 01-01.2019 and 01.01.2021 were retrospectively included in this study.
Results: We detected ICAD in 172 (20%) patients. While the independent risk factors of anterior ICAD were hypertension and diabetes mellitus, the risk factors of posterior ICAD were advanced age, diabetes mellitus, hyperlipidaemia and vertebral artery hypoplasia. There were more frequent posterior ICAD.
Conclusion: There was difference in the risk factors for anterior ICAD and posterior ICAD in this Turkish study.
Assessment of atrial electromechanical delay and echocardiographic parameters in patients with multiple sclerosis
Authors: Özdoğru Derya , Salkın Fatma Özge , Söker Elif Banu , Uysal Onur Kadir
Published: December 2023

Objective: Data on cardiovascular dysfunction is limited in the previous literature on patients with multiple sclerosis. In this study, we aimed to elucidate the cardiovascular parameters in multiple sclerosis patients by comparing the systolic-diastolic functions and atrial electro-mechanical delay compared to the control group.
Method: A total of 37 patients with a diagnosis of relapsing-remitting multiple sclerosis and had Expanded Disability Status Scale (EDSS) scores between 0 – 3, and 20 individuals in the control group were included in the study. Seventeen of the MS patients (n=17) were taking immunomodulatory drugs and the other 20 did not receive any immunomodulatory agents. Patients with a diagnosis or clinical suspicion of cardiac dysfunction and using cardiotoxic medications were excluded. The measurement of systolic and diastolic function parameters was performed via M – Mode 2D transthoracic echocardiography, and Atrial electro-mechanical delay (AEMD) measurements were performed with tissue Doppler.
Results: E’ MV lateral and MV E/A values were determined to be higher in MS patients, who did not use immunomodulatory drugs, compared to the control group (p<0.001, p=0.010 respectively). E/E’ MV lateral and MV AVmax values were determined to be significantly higher in the patient group using immunomodulators compared to the other two groups (p=0.009, p=0.012 respectively). PAs, PAI, left and right intraatrial EMG values were determined to be prolonged in MS patients using and not using drugs compared to the control group, but these values were not determined to be statistically significant.
Conclusion: We found that left ventricular diastolic function was impaired in MS patients compared to the control group, and right-left intra- and interatrial AEMD were similar. Based on these results, we recommend echocardiographic assessment for early detection of left ventricular diastolic dysfunction in MS patients.
The Cook Sorcerer: a game to assist in the treatment of symbolic behavior, favoring generalized recombinative reading in autistic children
Authors: França Fernanda Aline Costa , Ribeiro Francisco Adelton Alves , Pereira Alvaro Itauna Schalcher , Nascimento Dina Karla Placido , Silva Luis Fernando Maia Santos , Gonçalves Marcelo Eugênio de Castro , Meireles Floriza Gomide Sales Rosa , Alves Thiago Gomes
Published: December 2023

This article presents a game developed as an Educational Product resulting from the research of a Professional Master's Degree in Professional and Technological Education with the aim of assisting professionals in the field of Education and Health in teaching symbolic behavior, specifically the development of reading through discrimination and the recombination of syllabic units of words with students with Autism Spectrum Disorder (ASD) and other neurodevelopmental delays. The game was developed from collaborative work with students from the IT Technical High School at the Federal Institute of Education, Science and Technology of Maranhão (IFMA) Campus Codó, and is divided into tasks involving learning arrangements of two-syllable and three-syllable words, and positive reinforcement for teaching discrimination and recombination of syllables essential for literacy. Bibliographical research was carried out as a research methodology, using Applied Behavior as theoretical contributions. Analysis (ABA–Applied Behavior Analysis) and applied field research with students with ASD attended in the first literacy cycle in the Multifunctional Resource Room of the Emanuel Aroso Basic Education Unit. As results, we obtained an understanding of the way in which the teaching of relationships between stimuli and expansion for teaching reading and writing procedures in ASD is organized, such as: CRMTS (Constructed Response Matching to Sample – Matching to the model by constructed response) through the game. It is noteworthy that the aforementioned project covers the Priority Area of Technologies for Quality of Life, in the Health and Assistive Technologies sectors, established by ORDINANCE No. 1,122, OF MARCH 19, 2020, of the Ministry of Science, Technology, Innovations and Communications (MCTIC).
Desafios da formação docente para as tecnologias digitais na prática educativa
Authors: De Oliveira Raquel Mignoni , Morés Andréia
Published: December 2023

Este artigo contempla reflexões sobre a formação docente nos Anos Finais do Ensino Fundamental de uma escola da Serra Gaúcha e suas contribuições para o uso das tecnologias digitais nas práticas educativas. A pesquisa é qualitativa, de cunho analítico-interpretativo e tem como fontes de evidência documentos institucionais e entrevistas semiestruturadas realizadas com os docentes. Na análise dos dados investigados, que emergiram das entrevistas, utilizou-se a Análise de conteúdo (BARDIN, 2016). O corpus foi composto por docentes atuantes nos anos finais do Ensino Fundamental e na análise das entrevistas realizadas com eles procurou-se identificar de que modo a formação docente reverberou o uso das tecnologias digitais na prática educativa. Os resultados revelaram que as formações não conseguem contemplar todos os desafios existentes na profissão, no entanto, a formação permanente contribui, de modo efetivo, para as práticas educativas, pois faz com que o docente reflita sobre a sua própria prática, pense em estratégias para se desafiar diante do problema, transformando-o em oportunidade de aprimoramento profissional e pessoal. Além disso, evidenciou-se que as tecnologias digitais são consideradas importantes nos processos de ensino e de aprendizagem, mas são pouco utilizadas, pois há um distanciamento desses estudos durante os processos de formação docente.
O uso de biomarcadores salivares para o diagnóstico do carcinoma escamocelular oral: uma revisão sistemática
Authors: De Santana João Victor Atayde , Alves Paulo Eduardo Falcão de Assis , De Jesus Vinícius Lima , Martins Luciana da Silva , Soares Elda da Silva , Barreto Louise Rodrigues , Valente Alessandra Laíse Pinho , Cerqueira Joana Dourado Martins
Published: December 2023

A saliva é um fluido biológico que contém proteínas, DNA, RNA, hormônios e diversos outros metabólitos, apresentando contato direto com lesões e tumores de cavidade oral, sendo a sua utilização um meio de diagnóstico que apresenta grandes vantagens. O Carcinoma Escamocelular Oral é a mais frequente das neoplasias que acomete a região de cabeça e pescoço. O objetivo do presente estudo foi realizar uma revisão sistemática dos estudos que investigaram a utilização dos biomarcadores salivares para o diagnóstico de Carcinoma Escamocelular Oral. Foi realizada uma busca sistemática nas bases PubMed, Lilacs e Scielo, a fim de ter acesso aos artigos de relevância sobre este tema publicados de 2007 até 2022. Para a realização da sistematização dos resumos foi utilizado o programa Start Revisão Sistemática (Universidade Federal de São Carlos, Brasil). Após aplicação dos critérios propostos para elegibilidade, os artigos relevantes foram incluídos. Quarenta artigos foram selecionados e criteriosamente examinados. Foram encontrados 243 possíveis biomarcadores salivares para o diagnóstico do CEC, sendo que 64 apresentaram relevância significativa. A partir do que foi observado na presente revisão sistemática foi possível identificar que os biomarcadores salivares podem auxiliar no diagnóstico do CEC em cavidade oral nas diversas fases, desde lesões potencialmente malignas até o CEC oral bem diferenciado.
Química no ENEM: investigação dos princípios facilitadores da aprendizagem significativa crítica no período de 2015 a 2020
Authors: De Andrade Gecilaine Henriques , Lirio Cláudia Ferreira da Silva
Published: December 2023

O processo de aprendizagem está sempre presente em nossas vidas, mas ele só terá significado se te envolver de alguma forma, como possibilitar uma visão crítica do mundo que o cerca, analisar e resolver problemas, interpretar e compreender os fatos, perceber e atuar em situações do cotidiano, tendo condições de interferir em situações que contribuem para a sua qualidade de vida. Para que isso aconteça efetivamente no contexto escolar, relacionar os conteúdos científicos ao contexto social, político e econômico pode ser um dos caminhos para desencadear o processo de construção do conhecimento e da formação de um cidadão com capacidade de conhecer seus direitos e deveres, mediante a capacidade de julgar, de tomar decisão e, sobretudo, formar uma sociedade mais justa e democrática. Portanto, durante a pesquisa do trabalho de conclusão de curso, a presença dos princípios facilitadores da Teoria da Aprendizagem Significativa Crítica foi investigada nas questões do ENEM no período de 20015 a 2020. Após análise de conteúdo das questões, observou-se que elas apresentavam organizadores prévios e requeriam habilidades como a organização das ideias, através de um conhecimento prévio que estivesse integrado e contextualizado, avaliando a interpretação e o conhecimento do aluno. Portanto, com o desenvolvimento exploratório desse trabalho, espera-se contribuir para uma reflexão acerca do ensino-aprendizagem, a partir da análise das questões, do conteúdo de Química, presentes no ENEM.
The Effect Of Strategic Implementation on Organizational Performance of Saccos In Southwestern Uganda
Authors: Agaba Agaba  Moses , Bosco Turtasingura John , David Kabagambe Jesse
Published: December 2023

The purpose of the study was to examine the effect of strategy implementation on organizational performance of SACCOS in Uganda Case of Lyamujungu SACCO in Kabale District- Southwestern Uganda. The study employed a case study research design. It involved quantitative and qualitative methods which enabled the study to evaluate the relationship between the study variables at a snap shot. A sample of 140 respondents were selected using simple random sampling and purposive sampling techniques. The quantitative and qualitative data from the respondents was analyzed using SPSS Version 21.0 and thematic analysis respectively. Quantitative results in form of descriptive statistics, correlations and regressions were presented in tables based on the study objectives. The study found out that strategy implementation, has a positive significant relationship with organizational performance (r = .315, P≤.01). According to the study's conclusions, the Lyamujungu SACCO instance illustrates how strategy execution impacts organizational performance. According to the report, Lyamujungu SACCO's board of directors should implement its strategy effectively as staff members and clients carry out their job duties. The organization will be able to accomplish its goals of turning a profit thanks to this
Determinant on The Structural Performance of Krisnadwipayana University
Authors: Tio Lina , Yadewani Dorris , Ameen Ali , Alrajawy Ibrahin
Published: December 2023

The rise of knowledge-based technopreneurship has led to significant changes in work and the demands placed on organizations. Organizations are required to become a repository of innovation and nurture and retain talent resources. The primary purpose of this study is to investigate the impact that technological entrepreneurship, process innovation, and administrative innovation have had on the structural performance of Krisnadwipayana University. Students who made use of various smart government services were selected through a process known as random sampling. A total of 700 respondents were asked to participate in the survey, but only 403 did so, yielding a response rate of 57.57%. After removing missing data, outliers, and questionable replies, 372 respondents were evaluated. SmartPLS 3.0 was used to analyze research models using PLS and SEM-VB. The findings of this study add to what is known about technopreneurship in the academic and public sectors. They look at how innovations in technology, processes, and management affect the academic and administrative success of Krisnadwipayana University students.
The Influence of Perceived Organizational Support and Work-Life Balance on Turnover Intention Through Job Satisfaction
Authors: Naini Nurul Fitrianis , Riyanto Setyo
Published: December 2023

This study aims to analyze the effect of Perceived Organizational Support and Worklife Balance on Turnover Intention through Job Satisfaction as a Mediation variable. In this research, PT ABB's permanent employees with a total sample of 62 (sixty two) employees. The data analysis method uses Structural Equation Model-Partial Least Square (SEM-PLS) with SmartPLS 4.0. The results of the study found that Perceived Organizational Support had a positive and significant effect on Job satisfaction, Work-Life Balance had a positive and significant effect on Job Satisfaction, Work-Life Balance had a significant effect on Turnover Intention, Job Satisfaction had a positive but not significant effect on Turnover Intention, Perceived Organizational Support has a positive but not significant effect on Turnover Intention, Perceived Organizational Support has a Positive but Not Significant effect on Turnover Intention through Job Satisfaction. Work-Life Balance has a positive but not significant effect on Turnover Intention through Job Satisfaction. Company leaders are advised to increase Perceived Organizational Support and Work-Life Balance to increase Job Satisfaction which can affect Turnover Intention.
AMELIORATION OF CADMIUM STRESS ON TOMATO (LYCOPERSICON ESCULENTUM) BY TRIACONTANOL APPLICATION
Authors: SAEED MA , SHAHEEN MR , HUSSAIN R , ANJUM S , SARWAR M , SHABBIR A , TARIQ MBE
Published: December 2023

Lead (Pb), copper (Cu), zinc (Zn), and cadmium (Cd) tend to build up in the roots of tomato plants and are then taken up by the leaves and fruits, resulting in significant removal from the soil.  Plant growth and development are at risk due to the soil's buildup and toxicity of heavy metals (HMs). Cadmium, a hazardous element, inhibits the development and yield of tomatoes. Triacontanol (TRIA) enhances plant development when exposed to low concentrations of Cd, hence mitigating its harmful effects. This work used the exogenous triacontanol (TRIA) application to mitigate the adverse physiological impacts of cadmium (Cd) on tomato plants. The current study investigated tomatoes' physical characteristics, functions, and chemical composition to get a deeper understanding of how Triacontanol responds to stress caused by cadmium. Two experiments were laid out under a Completely Randomized Design (CRD), and three replications under a hydroponic system. In the first experiment, the effects of Cd on tomato were grown hydroponically and exposed to cadmium chloride at five concentration levels (control, 1.5, 03, 06 and 12µmol/L). While in the second experiment tomato grown hydroponically, and cadmium used in the form of CdCl2 at five concentration levels (control, 1.5, 03, 06 and 12µmol/L)  with one level of TRIA 10µM/L was be applied to facilitate the Cadmium stress on plant. The Hoagland's solution was  used to irrigate the plants after the initial 72 hours of pretreatment in both experiments at 35±1℃; 70-75%RH. Data for tomato plants' morphological, physiological, and biochemical characteristics was recorded. Results revealed that mitigation through triacontanol (TRIA) @ 10µmol/L best affects cadmium stress. It was noted that triacontanol (TRIA) @ 10µmol/L significantly affects tomato plants' morphological, enzymatic, and physiological characteristics at 1.5µmol/L of cadmium stress.