bluuebunny/crossref_metadata_2025 huggingface dataset:
Unraveling the Role of microRNAs in the Metastatic Landscape of Gastric Cancer
Authors: Zabeti Touchaei Arefeh , Vahidi Sogand
Published: January 2025

Gastric cancer (GC) continues to pose a major health issue worldwide, and diagnoses made at advanced stages frequently result in unfavorable outcomes. The metastatic spread of GC presents substantial therapeutic challenges, necessitating a deeper understanding of the tumor microenvironment (TME) and its interactions with cancer cells. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression and have been identified as key factors in the metastasis of GC. This review explores the biogenesis and functional mechanisms of miRNAs, highlighting their dual roles as oncogenes and tumor suppressors in GC metastasis. We discuss specific miRNAs that facilitate metastatic progression by influencing key pathways related to invasion, angiogenesis, and immune evasion. Furthermore, we examine the potential of miRNAs as diagnostic and prognostic biomarkers, offering insights into their utility in timely identification and tailored therapeutic approaches. By elucidating the complex regulatory networks involving miRNAs, this review underscores their significance as both therapeutic targets and biomarkers in the management of gastric cancer.
Nanocage-tethered Polymeric Hybridome for pDNA Delivery: A Revolutionary Approach for Treatment of Glioblastoma
Authors: Singh Dilpreet
Published: January 2025

Glioblastoma, a highly aggressive form of brain cancer, poses a formidable challenge in the field of oncology due to its resistance to conventional therapies and limited drug delivery options. This abstract highlights a groundbreaking strategy for combating glioblastoma by introducing a novel nanocage-tethered polymeric hybridome for the efficient and targeted delivery of plasmid DNA (pDNA). Our innovative approach combines the benefits of nanotechnology and polymer science to create a hybrid system capable of overcoming the inherent obstacles faced in glioblastoma treatment. The nanocage, acting as a carrier, not only ensures the protection and stability of the pDNA payload but also offers precise targeting capabilities. The tethering of polymers to the nanocage further enhances the biocompatibility, cellular uptake, and controlled release of pDNA. This nanocage-tethered polymeric hybridome has demonstrated exceptional potential in preclinical studies. It exhibits an unprecedented ability to penetrate the blood-brain barrier, specifically target glioblastoma cells, and efficiently deliver therapeutic pDNA payloads. Moreover, this approach minimizes off-target effects and reduces systemic toxicity, thus enhancing the safety profile. In conclusion, the development of the nanocage-tethered polymeric hybridome represents a paradigm shift in glioblastoma therapy.
Ginsenoside Rh4 Suppresses Notch3 and PI3K/Akt Pathway to Inhibit Growth and Metastasis of Gastric Cancer Cells
Authors: Beeraka Narasimha M , Nagalakshmi Allaka , Satyavathi Allaka , Kote Divya M , Reddy Y Padmanabha , Basappa Basappa , Nikolenko Vladimir N , Bannimath Gurupadayya , Bulygin Kirill V , P A Mahesh
Published: January 2025

Background: Rh4 (a compound derived from ginsenoside) has excellent anti-tumor property. It has been documented that an abnormally elevated level of Notch3 expression is linked to poor prognosis of gastric cancer (GC). Currently, the function of Rh4 in GC malignant progression is still unclear, and the manner in which Notch3 regulates GC progression remains undefined.
Methods: The level of Notch3 in GC cells was determined utilizing qRT-PCR and western blot. The relationship between Notch3 level and patient overall survival was forecasted by Kaplan-Meier Plotter database. The impacts of Notch3 and Rh4 on the biological characteristics of GC cells were examined through CCK-8, clone formation, scratch healing, and transwell assay. Using western blot, PI3K/Akt pathway protein levels were measured. Finally, a mouse subcutaneous transplantation tumor model was utilized to explore the influence of Rh4 treatment in vivo.
Results: The level of Notch3 was notably elevated in GC. The patient’s overall survival exhibiting high Notch3 levels was considerably lower than those with low expression. Silencing of Notch3 reduced GC cell viability and inhibited malignant progression. Rh4 exhibited a dose-dependent decrease in GC cell viability. In addition, Rh4 significantly suppressed Notch3 levels in GC cells, with over-expression of Notch3 attenuating the inhibitory influence of Rh4 on GC malignancy. Notch3 over-expression activated the PI3K/Akt pathway, while Rh4 effectively blocked this pathway by targeting Notch3, but PI3K agonists reversed this effect. Rh4 treatment reduced Notch3 expression and hindered tumor growth in vivo by inhibiting the PI3K/Akt pathway.
Conclusion: Notch3 expression was found to be heightened in GC, but Rh4 effectively suppressed PI3K/Akt pathway by targeting Notch3, and subsequently inhibiting cell proliferation, migration, and invasion.
Postpartum Clinicopathological and Reproductive Performance Assessment and Haptoglobin Measurement of Dairy Cattle with Retained Fetal Membrane
Authors:   Niigata Prefectural Chuo Livestock Hygiene Service Center, Hataya 686, Nishikan-ku, Niigata-city, Niigata, 959-0423, Japan, Nakamura Massaki , Miyamoto Toru ,   National Institute of Animal Health, NARO, 3–1–1 Kannondai, Tsukuba, Ibaraki 305–0856, Japan, Camer Gerry Amor ,   College of Veterinary Medicine, University of Eastern Philippines, Catarman, Northern Samar 6400, Philippines, Koyama Takeshi ,   Animal Biotechnology Group, Animal Research Center, Agricultural Research Department, Hokkaido Research Organization, Shintoku, Hokkaido 081-0038, Japan, Matsui Yoshitaka ,   Dairy Cattle Research Unit, Dairy Research Center, Hokkaido Research Organization, 7 Asahigaoka, Nakashibetsu-cho, Shibetsu-gun, Hokkaido, 086-1135, Japan, Sugiura Tomochika ,   Department of Large Animal Clinical Sciences, School of Veterinary Medicine, RakunoGakuen University, Ebetsu City, Hokkaido 069–8501, Japan, Moriyoshi Masaharu ,   Department of Large Animal Clinical Sciences, School of Veterinary Medicine, RakunoGakuen University, Ebetsu City, Hokkaido 069–8501, Japan, Nakada Ken ,   Department of Large Animal Clinical Sciences, School of Veterinary Medicine, RakunoGakuen University, Ebetsu City, Hokkaido 069–8501, Japan, Sawamukai Yutaka ,   Yokoo Domestic Animal Clinic, 2038-2 Sekiya, Nasushiobara City, Tochigi, 329- 2801, Japan
Published: January 2025

Cattle with retained fetal membrane (RFM) interrupts optimal dairy productivity including reproductive performance. In this 28-mo duration experimental study, several clinical tests (observation of morbid clinical signs, rectal temperature, vaginal discharge scoring, and blood inflammatory marker measurements) were completed in 19 cattle with RFM including 8 cattle with normally expelled fetal membrane. Twelve out of 19 cattle showed morbid clinical signs at 2.2 ± 1.3 days postpartum (dpp) and pyrexia at 2.3 ± 1.7 dpp. All cattle with RFM had vaginal discharge scores of 1–3 (4-point scale) that steadily persisted for 2–8 wk postpartum. Lower conception rates were noted in cattle with RFM than in cattle with no RFM (64% vs. 100%). Blood haptoglobin (Hp) levels of cattle with RFM and with morbid clinical signs were consistently elevated from 1–10 d (all P < 0.01). The Hp of test cattle for 3 d correlated with the ‘days open’ (Rs = 0.47). These findings have in effect validated the value of using Hp in assessing cattle with RFM. In addition to using Hp, regular clinical and laboratory tests as described herein should be integrated in the management of cattle with RFM.
In Vitro Seedling Growth of Adlay (Coix lacryma-jobi L.) ‘Pulot’ and its Response to 2,4-Dichlorophenoxyacetic Acid, Benzylaminopurine, Plain Cow Dung Ash and Agnihotra Ash
Authors:   Institute of Crop Science, College of Agriculture and Food Science, University of the Philippines Los Baños, College, Laguna, Philippines, Bernardo Emmanuel , Fernandez Pamela ,   Institute of Crop Science, College of Agriculture and Food Science, University of the Philippines Los Baños, College, Laguna, Philippines, Aspuria Evalour ,   Institute of Crop Science, College of Agriculture and Food Science, University of the Philippines Los Baños, College, Laguna, Philippines, Cadiz Nina ,   Institute of Biological Sciences, College of Arts and Sciences, University of the Philippines Los Baños, College, Laguna, Philippines, Marcelino Rocky ,   Institute of Statistics, College of Arts and Sciences, University of the Philippines Los Baños, College, Laguna, Philippines
Published: January 2025

Adlay (Coix lacryma-jobi L.) is an emerging alternative cereal crop which may benefit from plant tissue culture approaches. In this study, the morphogenic response of mature embryos of adlay to 2,4-dichlorophenoxyacetic acid (2,4-D; 1–3 ppm) and benzylaminopurine (BAP; 1–3 ppm) in Murashige and Skoog (MS) basal medium was screened in vitro. Further, agnihotra ash (AA) and cow dung ash (CDA) were evaluated as unconventional culture media additives. A sterilization procedure was first developed for mature embryos of adlay by varying sodium hypochlorite (NaOCl) concentration and the duration of surface sterilization. NaOCl at 1% (v/v, Chlorox®) using double sterilization (7 min: 8 min) was effective for surface disinfection of dehusked adlay seeds. In terms of plant growth regulators (PGRs), BAP and 2,4-D enhanced shoot growth in lower doses, but primary root growth was inhibited. Retarded shoot and root development were observed even at the lowest 2,4-D concentration and as BAP was increased. Yellow, compact callus was observed surrounding the mesocotyl and white crystalline and loose callus around the radicle region. Both types of calli appeared non-embryogenic and were most frequent at 2 and 3 ppm 2,4-D regardless of BAP concentration and ash additives. As for ash additives, application of 0.01% cow dung ash, 0.01% agnihotra ash and 1% cow dung ash resulted in larger seedlings compared with 1% agnihotra ash in basal media, although these differences were not pronounced in the plant growth regulator (PGR) background. Agnihotra ash and cow dung ash as miscellaneous additives may provide cost savings in plant tissue culture; further work is warranted.
Sex differences in kinematics and muscle activity during the impact phase of a single-leg landing task after a backhand side overhead stroke in badminton
Authors: Zhang Yanan , Wang Ting , Kim Youngsuk , Kim Sukwon , Hu Zhe
Published: January 2025

Background: Female badminton players have a higher risk of anterior cruciate ligament (ACL) injury in landing maneuvers compared to males. Gender differences in neuromuscular control may be a potential risk factor for the increased incidence of ACL injury in female badminton players. Study design: Controlled laboratory study. Methods: Sixteen badminton players (8 male, 8 female) participated in a badminton single-leg landing task in which lower limb kinematics, ground reaction forces, and lower limb muscle activity were measured using a marker-based motion capture system, force plates, and electromyography (EMG). An analysis of variance (ANOVA) was used to analyze gender differences in leg kinematic data, mean normalized leg muscle activation (MVC%), and muscle co-contraction during the impact phase after landing. Results: During the impact phase of the badminton landing task (100 ms after initial contact), the knee valgus angle at the moment of initial contact (IC) and posterior peak ground reaction force (GRF) was greater in females than in males (6.27 ± 2.54 vs 1.84 ± 3.28) and (6.16 ± 2.83 vs 0.88 ± 2.59). Knee flexion angle and ankle plantarflexion angle were less in females than in males at the moment of peak posterior GRF (16.71 ± 4.20 vs 23.90 ± 5.04) and (−28.34 ± 5.60 vs −37.05 ± 7.17). During the post-landing impact phase, compared to male badminton players, females exhibited greater rectus femoris (51.85 ± 15.68 vs 19.73 ± 6.63) medial hamstring (44.88 ± 19.07 vs 20.54 ± 10.16), medial gastrocnemius (66.23 ± 21.42 vs 38.21 ± 15.16) lateral gastrocnemius (79.43 ± 22.54 vs 46.53 ± 13.17) muscle activity. In addition, males exhibited a higher co-contraction ratio of the medial and lateral gastrocnemius compared to female athletes (1.44 ± 0.46 vs 0.99 ± 0.24). Conclusion: There were significant gender differences in neuromuscular control (muscle activity patterns, movement patterns) between badminton players during the impact phase of the badminton single-leg landing task. These findings highlight the need for gender-specific training programs to address neuromuscular differences and reduce ACL injury risk in badminton players.
Quality analysis report of Cistanche tubulosa and Cistanche deserticola
Authors: Li Xianzhi , Mao Qiongli , Yang Qiang , Li Qiang , Huang Zhian , Zhu Jiaosheng , Zhu Yan , Hu Yang , Shi Hao
Published: January 2025

The medicinal materials of Cistanche tubulosa (CW) and Cistanche deserticola (CD) were selected to carry out the determination of bioactive substances and antioxidant activity and multivariate statistical analysis. The results of active substance analysis showed that there were significant differences in the content of total polysaccharides between the two varieties, and there were significant differences in the contents of total polyphenols, total flavonoids, total triterpenoids, proanthocyanidins, phenylethanoid glycosides, amino acids, proteins and heavy metals. The total polysaccharides in CW were higher than those in CD. The contents of total polyphenols, total flavonoids, total triterpenes and phenylethanoid glycosides in CW were significantly higher than those in CD. The contents of amino acids, proteins and heavy metals in CD were higher than those in CW. The results of antioxidant analysis showed that the DPPH free radical scavenging ability, ABTS free radical scavenging ability and ORAC superoxide radical scavenging ability of CW were significantly higher than those of CD, and there was a significant difference between the two varieties. Correlation analysis showed that the antioxidant capacity of Cistanches herba was closely related to the contents of total polyphenols, total flavonoids, total triterpenes, total polysaccharides, phenylethanoid glycosides, proanthocyanidins, amino acids, proteins and heavy metals. The samples were divided into two groups by cluster analysis. Four principal components were extracted by principal component analysis, and the cumulative variance contribution rate was 94.15%.
Effectiveness of a preventive training program in reducing injury rates in college athletics
Authors: Huang Tao
Published: January 2025

In order to reduce the incidence of injuries in college athletics, this study used a computer-assisted preventive training program for analysis. The effects of different training intensities and recovery strategies on athlete injuries were investigated by establishing an athlete injury prediction model, combining personalized training programs with real-time data feedback. The results showed that the computer model-based training program could significantly reduce the injury rate and enhance the performance and recovery efficiency, which verified the effectiveness of personalized training in reducing sports injuries.
The Affecting Mechanism of Academic Atmosphere on Student Nurses’ AI Literacy in Yunnan Province of China
Authors: Luo Xiangqi
Published: January 2025

AI is a key tool for enhancing students’ future achievement, and atmosphere is associated with AI literacy. Therefore, this study used purposive sampling with an electronic questionnaire to obtain a sample of 1039 student nurses from 6 schools in Yunnan Province, China (validity rate 86.583%) to investigate the relationship between academic atmosphere and student nurses’ AI literacy, as well as the facilitating effects of career calling and Chinese chivalrous personality. The results show that academic atmosphere is positively related to the AI literacy of student nurses, and that career calling and Chinese chivalrous personality have a facilitating effect in Yunnan Province, China. This suggests that student nurses need not only the support of the school’s diverse external environment but also the connection between pro-social values and traditional Chinese cultural personality to enhance their mastery of AI tools adequately in Yunnan Province, China.
Complications of lower extremities in patients with diabetes mellitus
Authors:   Russian Medical Academy of Continuous Professional Education, Komelyagina Elena , Antsiferov Mikhail ,   Russian Medical Academy of Continuous Professional Education
Published: January 2025

The review provides data on complications of the lower extremities in patients with diabetes mellitus: diabetic peripheral neuropathy, impaired arterial blood flow in the lower limbs, diabetic foot syndrome. The issues of their pathogenesis, diagnosis, and differential diagnosis are outlined. The principles of therapy and prevention of diabetes mellitus complications are considered.
Národní boj na periferii: Proces etnické sebeidentifikace obyvatel obce Panenská u Jemnice na přelomu 19. a 20. století
Authors: Lochmanová Jana
Published: January 2025

Jihozápadní Morava byla až do poloviny 20. století etnicky pestrá a řada obyvatel tohoto regionu se vyznačovala fluidní etnicitou. Na příkladu příhraniční obce Panenská (Frauendorf, Flandorf) je zpracována studie o procesu etnické sebeidentifikace obyvatel v etnicky smíšené obci na přelomu 19. a 20. století. Cílem je ukázat jak vývoj etnické sebeidentifikace obyvatel obce, ale i to, kdo byli hlavní aktéři, kteří proces sebeidentifikace ovlivňovali, a jaké strategie využívali. Studie se soustředí na rozbor etnické situace na základě analýzy a interpretace archivních materiálů (cenzy, matriky, kroniky, zápisy z jednání zastupitelstva obce, novinové články). Při zpracování tématu byl zohledněn také ekonomický a politický vývoj v obci.
مطالعه‌ی احصائیوی تفاوت جنسیتی در استفاده از انترنت (محصلین پوهنځی کمپیوترساینس پوهنتون کابل)
Authors: شهیدزی امیرکروړ , زرین‌خیل محمدشعیب
Published: January 2025

هدف این مطالعه پیدا کردن تفاوت جنسیتی در استفاده از انترنت توسط محصلین پوهنځی کمپیوترساینس پوهنتون کابل بود. در این تحقیق به تعداد (200) نفر از میان تمامی محصلین پوهنځی با استفاده از روش نمونه‌گیری تصادفی طبقه­یی انتخاب شدند و پرسش‌نامه­یی با 14 سؤال با گروپ یاد شده جهت جمع‏آوری دیتا شریک ساخته شد. در این تحقیق روش جمع‏آوری دیتا به‏شکل سیستماتیک صورت گرفته است. برنامه (SPSS) که یک وسیله‌ی معیاری به‏حساب می­آید، بخاطر بررسی و تحلیل دیتا استفاده شد. در این پروسه از جمله­ی ۲۰۰ نفر انتخاب شده به تعداد 163 تن شرکت نموده و به سؤال­ها پاسخ ارایه کردند. این تعداد اکثریت گروپ مورد نظر را تشکیل داده و در اعتباربخشی به ارقام جمع‏آوری شده کمک نمود. بعد از تحلیل و مطالعه دیتا نتیجه­ی تحقیق در چهار مورد متمرکز گردید.
په افغانستان کې د ټولنې پر بنسټ د ناوړه پېښو د زیان مدیريت او نقشه کښنې ته کتنه
Authors: پیروز شریف الله , مشوانی حیات‌الله
Published: January 2025

د ټولنې پربنسټ د پیښې ګواښونو مدیریت هغه پروسه ده چې د پیښو پر وړاندې د ټولنې د مقابلې وړتیا لوړوي او د زیانونو کچه راټیټوي. لدې څیړنې څخه موخه داده چې په افغانستان کې د پیښو پر وړاندې تاب راوړونکي خلک، ټولنې او چاپیریال رامنځ ته شي. په دې څیړنه کې له کتابونو، نړیوالو مقالو، ژورنالونو، راپورونو او په مختلفو ولایتونو کې د ټولنې وګړو لخوا د ټولنې نقشې جوړولو له لاري روان حالات ارزوول شوی او په پایله کې په ډاګه شوې چې په افغانستان کې د ټولنې پر بنسټ د پیښو ګواښ مدیریت کچه ډیره ټیټه ده، اود شته وضعیت د بدلون او ښه والي لپاره باید د هیواد د هر کلي په کچه د پیښو مدیریت ټولنې او سازمانونه رامنځ ته  او وده ورکړل شي.
چارچوب انکشاف پلان استراتیژیک برای آموزش الکترونیکی در تحصیلات عالی
Authors: عدلیار سیدحسن
Published: January 2025

استفاده از تکنالوژی معلوماتی در تدریس و آموزش به‏نام آموزش الکترونیکی یاد می‏شود. نتایج تحقیقات علمی نشان می‏دهد که آموزش الکترونیکی فرصت‏های جدید آموزشی را برای محصلان مهیا می‏سازد. اگر آموزش الکترونیکی در پوهنتون‏های کشور مطابق شرایط تطبیق شود، سبب نتایج مثبت در کیفیت تدریس و آموزش می‏شود. با وجود کوشش‏های زیاد هنوز پروسۀ تطبیق آموزش الکترونیکی در پوهنتون‏های کشور با مشکلات مواجه است. در پهلوی سایر مشکلات، نداشتن پلان منظم برای تطبیق آموزش الکترونیکی یک چالش مهم می‏باشد. در این مقالۀ تحقیقی، برای تهیۀ چارچوب انکشاف پلان استراتیژیک آموزش الکترونیکی از روش تحقیق مرور بر آثار و روش تحقیق موردی استفاده گردیده است. با مطالعۀ تحقیقات علمی در زمینۀ آموزش الکترونیکی و جمع‌آوری دیتا از پوهنتون‏ها و تحلیل آن، چارچوب انکشاف پلان استراتیژیک آموزش الکترونیکی دیزاین گردیده است. از چارچوب پیشنهادی پوهنتون‏های کشور برای تهیه پلان استراتیژیک آموزش الکترونیکی استفاده کرده می‏توانند.
څېړنه او د علمي څېړنو ډولونه
Authors: سالاري محمدولی , وردک محمد شفیق , شفیق خاټول
Published: January 2025

تحقیق یا څېړنه یوه منظمه سیتماتیکه پروسه ده، چې د نامعلومو مسألو د موندنې او یا د مسألو د ژورو درک لپاره کېږي.څېړنه اکثراً له منل شویو څېړنیزو میتودونو څخه په استفادې، یوې ستونزې ته د حللارې یا پوښتنې ته د حل موندنې په موخه ترسره کېږي. څېړنه  د ساینسي پرمختګ لپاره حیاتي وسیله ده، ځکه؛ څېړونکيو ته اجازه ورکوي چې د روښانه تعریف شويو پیرامیټونو، چاپیریالونو او انګېرنو پر اساس فرضیه ثابته یا رد کړي. د څېړنې پر ډولونو پوهیدنه؛ له څېړونکي سره د خپلې څېړنیزې پروژې  پر ښه پلان سربېره؛ مرسته کوي چې له تر ټولو مناسبو میتودونو او تخنیکونو څخه په استفادې باوري پایلې ترلاسه او خپلې څېړنیزی موندنې له نورو څېړونکيو سره په انلاین او یا په کتابي بڼه شریکې کړي. دا علمي مقاله د توصيفي څېړنې څخه په استفادې؛ چی اکثر معلومات یی د کتابونو او علمي مقالو څخه راټول شوي دي، لوستونکيو؛ په تېره څېړونکيو ته د څېړنو بېلابېل ډولونه  ور په ګوته  کوي، چې ترې په ګټې اخیستني  سره باکیفیته علمي څېړنې په ښه بڼه پلان او ترسره کړي. د دی څېړنې پایلې؛ علمي څېړنې د څېړنو د هدف، د معلوماتو را ټولونې، او د معلوماتو د څرنګوالي (د شمېرو ماهیت) پر اساس په څو برخو وېشي، چی تفصیل یې د مقالې په بېلابېلو برخو کې واضح شوی دی.
A Comprehensive Study of the Quinoline Heterocyclic Ring and its Biological as on Antimalarial and Anticancer Agent
Authors: Heravi Nasir Ahmad , Firoozkohi Ahmad Zaher , Mohammadi Mostafa
Published: January 2025

Quinoline is a preferred scaffold that emerges as a significant assembly motif for the creation of novel pharmacological molecules among heterocyclic compounds. Due to the extensive spectrum of biological and pharmacological properties of quinoline and its derivatives, numerous synthetic pathways have been created for their synthesis. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. As a result, these compounds have been produced as intentional structures, and their biological activities have been assessed by numerous scientific communities. This review will investigate the quinoline heterocyclic ring, also the antimalarial and anticancer biological effects of quinoline derivatives.
کاربرد کتلستی کامپلکس های فلزات انتقالی لیگاند های تیوسیمی کاربازون در تعاملات عضوی
Authors: پولادیان کیومرث , محبت محمد ظاهر
Published: January 2025

در بین لیگاند هاییکه دارای اتوم های دونر مانند نایتروجن و سلفر هستند، تیوسیمی کاربازون ها (thiosemicarbazones) به دلیل انعطاف پذیری و حساسیت آنها نسبت به آیون های فلزی مختلف از جمله لیگاندهای مهم بشمار میروند. موجودیت اتوم های دونر مانند اکسیجن (O)، نایتروجن (N) و سلفر (S) در ترکیب لیگاند های تیوسیمی کاربازون باعث به میان آمدن اشکال کواردنیشنی متفاوت شده اند. به همین ترتیب، موجودیت گروپ های مختلف مانند میتایل، فینایل در موقعیت N آخری، می توانند حالت کواردنیشن و خواص کتلستی کامپلکس ها را تغییر دهند. این مرکبات بخاطر طرز تهیه ساده، تشکیل کامپلکس های عالی نه تنها عناصر انتقالی بلکه عناصر غیرانتقالی -p، ویژه گی های ساختاری جالب کامپلکس هایشان و امکان کاربرد کتلستی شان بسیار مورد توجه قرار دارند. در این مقاله ای مروری به بررسی کاربرد کتلستی کامپلکس های فلزات انتقالی در اجرای تعاملات مختلف عضوی میپردازم.
CSR IN INDIA: A COMPARATIVE STUDY OF TATA AND RELIANCE
Authors:   Lakshmibai College, University of Delhi, Delhi, India, Porchelvi A. , Suri Ritu ,   Lakshmibai College, University of Delhi, Delhi, India, Singh Juhi ,   Lakshmibai College, University of Delhi, Delhi, India
Published: January 2025

Corporate Social Responsibility is the imperative of time for all business entities. Traditional method of Business practices has no longer suitable to competitive business world. CSR performance would be the best option for the sustainability of companies. This paper aimed to overview the CSR activities contributed by India’s top most two business groups in Indian major sectors of education structure, health System, environmental care and empowerment. For this purpose, secondary data collected CSR reports of TATA &RELIANCE group firms and evaluated the CSR performance. It is concluded that these two business giants are the significant contributors to Indian economy and society with their amazing responsible initiatives and efforts. The outcome of the paper will motivate other business entities to do more CSR works and it will boost up their profitability, Productivity and reputation.
Estudio de Equipos Open Source orientados al uso de Aplicaciones Industriales
Authors: Romero Bedón Freddy Rodrigo
Published: January 2025

Se realizó un estudio sobre equipos open source orientados a aplicaciones industriales durante el período 2019-2023, con el objetivo de evaluar su evolución, adopción y efectividad en diferentes sectores industriales. La investigación se basó en el análisis documental sistemático de 312 publicaciones relevantes y la evaluación comparativa de diferentes tipos de equipos open source en entornos industriales. Los resultados mostraron una reducción significativa en costos de implementación (30-40%) y mantenimiento (45-55%) en comparación con soluciones propietarias. El sector manufacturero presentó la mayor tasa de adopción (45%), seguido por el sector energético (38%). Se identificaron desafíos importantes como la documentación incompleta (35%) y el soporte técnico limitado (28%). La evolución temporal evidenció una maduración significativa de estas tecnologías, progresando desde capacidades básicas hasta funcionalidades avanzadas que incluyen integración con IA y análisis predictivo. Los beneficios cuantificados incluyeron mejoras en flexibilidad operativa (40-50%) y aceleración en innovación y desarrollo (45-55%). Las tendencias emergentes señalaron una clara dirección hacia la automatización avanzada y la digitalización industrial. Se concluyó que los equipos open source representan una alternativa viable y ventajosa para aplicaciones industriales, aunque su implementación exitosa requiere una consideración cuidadosa de los desafíos identificados.
Análisis y evaluación de la generación distribuida fotovoltaica como alternativa para mitigar la crisis energética en Ecuador
Authors: Pazuña Naranjo William Paul
Published: January 2025

Este estudio evaluó el potencial de la generación distribuida fotovoltaica como alternativa para mitigar la crisis energética en Ecuador. Se empleó un enfoque metodológico mixto que incluyó revisión sistemática de literatura, análisis de datos satelitales de la NASA-POWER, modelado computacional y análisis de escenarios. El análisis de radiación solar reveló condiciones excepcionales en Ecuador, con valores entre 4.0 y 5.2 kWh/m²/día, destacando la región Costa, particularmente Santa Elena, como la zona más favorable. Se desarrollaron tres escenarios de implementación hasta 2050: BAU (2,800 MW), Transición Moderada (11,500 MW) y Alta Penetración (35,000 MW). Los resultados demostraron que la implementación de sistemas fotovoltaicos distribuidos podría reducir las pérdidas técnicas en la red entre 8% y 15%. El análisis económico confirmó la viabilidad financiera con períodos de recuperación de 4 a 8 años y TIR de hasta 22% para sistemas industriales. Los beneficios ambientales proyectados alcanzaron reducciones de hasta 21,000 kt CO₂/año en el escenario de Alta Penetración. La validación del modelo mostró una concordancia del 92% con datos operativos existentes. El estudio concluyó que la generación distribuida fotovoltaica constituye una alternativa viable para mitigar la crisis energética en Ecuador, requiriendo un marco regulatorio favorable y políticas de incentivos adecuadas para maximizar su implementación.
Impacto del uso de tecnología en el desarrollo cognitivo de estudiantes de décimo grado; un estudio de caso en la Unidad Educativa Fiscomisional San Juan Evangelista
Authors: Marcillo Fabricio , López Damaris , Inchiglema Kerly , Begnini Lucía
Published: January 2025

La tecnología actual ha impulsado relevantes cambios en el desarrollo educativo, generando formas de interacción y acceso al conocimiento que se fundamenta con el apoyo de recursos digitales. Este referente permite describir la orientación del artículo, cuyo propósito es analizar el efecto del uso de la tecnología en el desarrollo cognitivo de los estudiantes de décimo grado en la Unidad Educativa Fiscomisional San Juan Evangelista, ubicado en el cantón Pedro Vicente Maldonado, provincia de Pichincha, Ecuador. La metodología caracterizó un enfoque cuantitativo, con un alcance descriptivo, no experimental y transaccional; por lo cual fue oportuno destacar también un alcance propositivo ante el diseño de un programa de alfabetización. La muestra seleccionada estuvo representada por cuarenta y cinco estudiantes del décimo grado, a los cuales se le aplicó un cuestionario con doce preguntas consolidadas por medio de un instrumento priorizado. Los resultados evidenciados permitieron evaluar el efecto de la tecnología en función del uso de los dispositivos, el conocimiento de las herramientas digitales, el desarrollo de habilidades, la motivación y compromiso y la importancia que tiene la conciencia digital para el aprendizaje. Las conclusiones consolidaron el efecto significativo e influyente que tiene la tecnología en el desarrollo cognitivo de los estudiantes, porque representa una actividad funcional en el aprendizaje y su disposición y acceso a los recursos les permite generar una forma de interacción relevante para el aprendizaje y su desarrollo formativo.
Análisis del Control Interno y su influencia en la toma de decisiones de los supermercados del cantón La Maná
Authors: Paredes Merchán Henry Ronaldo , Zambrano Mera Kristel Damaris , Torres Briones Rosa Marjorie , Hurtado García Ketty del Rocío
Published: January 2025

Este estudio analizó la influencia del control interno en la toma de decisiones de los supermercados del cantón La Maná, Ecuador. Se aplicó un enfoque metodológico mixto, utilizando encuestas y cuestionarios basados en el modelo COSO I, a una muestra de seis gerentes de supermercados. Los resultados revelaron variaciones significativas en la implementación de los componentes del control interno. Se encontraron fortalezas en el ambiente de control y las actividades de control, con el 83.3% de los supermercados contando con objetivos organizacionales definidos y el 66.7% implementando indicadores de eficiencia. Sin embargo, se identificaron debilidades en la evaluación de riesgos y la supervisión, con solo el 50% de los establecimientos realizando actividades de detección de riesgos y apenas el 33.3% evaluando frecuentemente sus controles internos. El análisis estadístico mostró una correlación positiva significativa (r = 0.78, p < 0.05) entre el nivel de implementación del control interno y la efectividad en la toma de decisiones. Además, los supermercados con niveles más altos de control interno reportaron una mayor satisfacción con sus procesos de toma de decisiones. Estos hallazgos subrayan la importancia del control interno como una herramienta estratégica para mejorar la gestión y la toma de decisiones en los supermercados, destacando la necesidad de fortalecer los sistemas de control interno, especialmente en las áreas de evaluación de riesgos y supervisión.
Evaluación del impacto de las redes sociales en las ventas de la empresa mega ferretería Bonilla del cantón La Maná
Authors: Villon Ruiz Génesis Elizabeth , Calderón Ramírez Grace Mabel , Medina López Enry Gutember , Martínez Ortiz Fabian Xavier
Published: January 2025

Esta investigación evalúa el impacto de las redes sociales en las ventas de Mega Ferretería Bonilla en el cantón La Maná, Ecuador, durante el período 2018-2024. Mediante un estudio mixto con diseño correlacional y longitudinal, se analizaron datos de ventas mensuales, 5,000 publicaciones en redes sociales, y se realizaron encuestas a 100 clientes y entrevistas a 5 empleados del área de marketing digital. Los resultados revelaron un incremento del 51.8% en las ventas mensuales promedio tras la implementación de estrategias en redes sociales, con una fuerte correlación positiva (r = 0.83) entre la actividad digital y las ventas. TikTok emergió como líder en engagement (45.3%), mientras que WhatsApp demostró la mayor efectividad en conversión (8.9%). Los videos demostrativos generaron el mayor engagement (8.45%), estableciéndose como el formato más efectivo. El análisis del ROI por plataforma mostró resultados significativos: TikTok (165%), WhatsApp (189%), Facebook (134%) e Instagram (112%). Esta investigación proporciona evidencia empírica sobre la efectividad de las estrategias digitales en el sector ferretero tradicional, demostrando que la transformación digital, cuando se implementa estratégicamente, puede generar beneficios tangibles en términos de engagement, conversión y ventas.
Inclusive journalism : an investigation into LGBTI topics and homonationalism in the news
Authors:   , Verhoeven Emma
Published: January 2025

Homonationalism, the instrumentalization of LGBTI acceptance for nationalist, xenophobic, or Islamophobic purposes, has become widespread in Flanders. This dissertation sets out to investigate homonationalism through the lens of journalism, investigating its characteristics and prevalence in a mediatized context. This dissertation engages with the notion of inclusive journalism to analyze journalistic practices regarding LGBTI topics. Chapter 1 sets out to provide a comprehensive view of the Flemish media landscape regarding LGBTI topics by analyzing 1,570 articles published by thirteen Flemish news outlets in 2021. To this end, an inductive framing analysis was combined with quantitative content analysis. The findings indicate that most articles are framed inclusively, but also demonstrated the large share of homonationalist frames. Chapter 2 provides a critical discourse analysis of othering discourses in mainstream and alternative news media coverage of an alleged homophobic murder in March 2021. This study highlights the differences between mainstream media, which anchor the gay-friendly position of Belgium, and right-wing alternative media, that extend this discourse with overt Islamophobia. Chapter 3 features a thematic analysis of 1,127 user comments under articles of PAL NWS, a far-right medium that frequently positions LGBTI topics in a culture war discourse. This chapter highlights how homonationalism and LGBTI-phobia coincide and even reinforce each other, resulting in discriminatory discourses about Muslims and non-homonormative LGBTI people. Chapter 4 moves away from news content and investigates how journalists view their role in inclusive coverage, and how they reconcile this with notions of objectivity. Through seventeen semi-structured interviews, this study shows that perspectives between journalists differ between an objectivity model, an inclusivity model, and an advocacy model. This chapter also lists three challenges to more inclusive coverage: implementing guidelines, providing room for reflexivity, and removing intersectional shortcomings. Taken together, the findings underscore the critical role of journalism in shaping public discourse on LGBTI issues and the importance of inclusive journalistic practices. The presence of homonationalist discourses in mainstream media highlights the need for ongoing critical scrutiny and the promotion of alternative narratives that challenge exclusionary ideologies. Additionally, the investigation into journalistic practices reveals that fostering inclusivity requires a commitment to reflecting diverse perspectives and addressing social justice issues comprehensively.
Dry, bi- and oxidative CO2 reforming of CH4 in an atmospheric pressure glow discharge reactor : an experimental study
Authors:   , Wanten Bart
Published: January 2025

Several established processes face a significant cost to capture and store CO2, required to avoid its emission. Therefore, processes that are electricity driven, coupled to a renewable energy source, while providing a pathway to valorise CO2 and other greenhouse gases are required. In this thesis, I focus on the combined conversion of CO2 and CH4 (the so-called dry reforming of CH4) by means of a plasma reactor, in particular a confined atmospheric pressure glow discharge. Specifically, I conducted experiments for a wide range of conditions and additive gases, with the goal to find the optimal reaction conditions with this specific plasma reactor, that leads to the formation of syngas, a mixture of CO and H2. Syngas can be further processed into a variety of liquid fuels, such as methanol and various long-chain hydrocarbons, depending on the relative amount of CO and H2. An excellent performance compared to the state-of-the-art is achieved. Specifically, a CO2 and CH4 conversion of 64 % and 94 % is reached, respectively, at an energy cost of 3.2-4 eV/molecule. The confinement in the plasma is assumed to play a crucial role with regards to these excellent results. Unfortunately, the product output’s value remains limited, as soot formation limits the use of sufficiently high amounts of CH4 with this setup, necessary to achieve a syngas ratio (H2/CO) that is high enough for further processing towards various liquid chemicals. A potential solution for this issue is the addition of other gases next to CO2 and CH4 that can avoid the formation of soot particles to some extent. When a small fraction of O2 is added (the so-called oxidative CO2 reforming of CH4), the syngas ratio is only slightly improved. The bi-reforming of CH4, where H2O is added instead of O2, effectively helps in counteracting soot formation. Moreover, a syngas ratio of 2 is reached, which is ideal for further methanol synthesis. Finally, these processes are compared in terms of environmental impact and economic potential. Oxidative CO2 reforming of CH4 is found to be the most promising process, with a score twice as high as for the bi-reforming of CH4 process on almost all environmental parameters considered. Compared with current syngas production technologies, all three plasma processes lead to an improved environmental performance. These results show the potential of a bright future for plasma-based syngas production.
Konsum und materielle Kultur ländlicher Haushalte in Westfalen, spätes 16. bis frühes 19. Jahrhundert
Authors:   , Bovenkerk Henning
Published: January 2025

This study analyses the development of consumption and material culture of rural households in Westphalia between the late 16th and the early 19th century on the basis of probate inventories from five study areas. Based on the concept of the consumer revolution, the aim of the study is to trace developments of the revolution in rural north-west Germany in the early modern period. It becomes evident, that there are changes that are in line with the consumer revolution, in regards for example of textiles made of imported fibres, that hint to a fundamental change of the qualitative nature of consumption. But these changes are limited only to the upper social strata and decrease in the lower social strata.
Human Trafficking in Pakistan: Legal Framework and Challenges
Authors: Sultana Munawwar
Published: January 2025

Human trafficking is a criminal act of modern society which threatens millions of people all over the world. According to the world situation of socio-economic conditions and geographical location, this scourge affects Pakistan more than any other nation. The purpose of this study is to establish a review of human trafficking in this country to the legal system, which will reveal some of the difficulties of implementing it and the country's recommendation on how the problem can be addressed adequately. The paper also looks at the International and domestic laws in relation to human trafficking in Pakistan and the effectiveness of each law. It also looks at the different issues that surround the fight against this crime, among them inadequate funding, corruption, and ignorance. In addition, the research also examines the grim consequences that tender victims of humans, both sexually and psychologically. In response to these issues and in order to mitigate and comb human trafficking effectively, the following has been recommended. These include enhancing legal measures, identification of victims, provision of assistance to victims, country's cooperation with international organizations, and combating social and economic factors that lead to vulnerability. This way, Pakistan can reduce the rates of human trafficking and protect its citizens if these recommendations are followed. This research will be of significant interest and utility to any government, police force and NGOs that are struggling to contain this world problem.
Influência da Psicomotricidade no Desenvolvimento e Aprendizagem Infantil na Pandemia
Authors: Silva Junior Agenor  Sousa , Silva Fabrícia Gomes da , Dantas Ianka da Silva
Published: January 2025

Após a declaração da pandemia pela Organização Mundial da Saúde (OMS) em 2020, devido à dispersão da Covid-19, o governo brasileiro suspendeu as aulas em todas as instituições de ensino. Este trabalho mostra abordagens e práticas utilizadas pelos professores para fomentar o desenvolvimento socioeducacional de alunos da Educação Infantil por meio de atividades psicomotoras durante as aulas remotas. A pesquisa possui uma abordagem qualitativa e é do tipo estudo de caso. O objetivo foi examinar como os professores enfrentaram os desafios durante o período mais crítico da pandemia e adaptaram suas práticas para cumprir seu papel social. Quando situações inesperadas alteram a vida das pessoas e setores específicos da sociedade, torna-se fundamental compreender todos os aspectos, positivos ou negativos, que possam impactar a sociedade.
The impact of postgraduate education on career advancement in healthcare
Authors: Kotsur Nadiіa
Published: January 2025

The study aimed to describe the mechanisms through which postgraduate education influences career advancement. The findings were synthesised to systematise the research outcomes and formulate conclusions, encompassing the components of postgraduate education, career advancement factors, and their interrelationships. The results underscored the role of postgraduate education in fostering the career development of healthcare professionals. Both formal educational programmes and informal learning opportunities that contribute to professional growth were analysed. The study identified the following conceptual models: human capital, social learning theory, signalling theory, and social capital theory. These models were examined in the context of existing theories explaining the impact of education on career progression. The advantages and disadvantages of each model were assessed, along with their applicability to the healthcare sector and potential limitations. A comparison of the models was conducted to identify common elements and integrate them into a unified conceptual framework. The results indicated that postgraduate education significantly enhances competence, job satisfaction, and opens additional opportunities for career advancement. It was found that specialists who have gained additional education in related fields are more effective when working in interdisciplinary teams to address complex medical issues. This makes them valuable team members and fosters career advancement. It was also identified that investments in education and professional development correlate with improvements in the quality of medical services. These findings emphasised the importance of supporting continuous education to maintain high standards in healthcare. The results of the study can be used by organisations responsible for licensing healthcare institutions to establish requirements and standards for continuous professional education
Pedagogical practice in the system of professional training for higher education students: Through the lens of contemporary realities
Authors: Yuriychuk Nataliya , Dadak Dmytro
Published: January 2025

The reform of higher pedagogical education in Ukraine requires teachers to attain a high level of professional competencies. In the modern period, it is essential to study pedagogical practice as it contributes to developing the necessary skills and competencies that are key to the successful professional formation of future specialists. This article aimed to explore the role and place of pedagogical practice in the professional training system for higher education students through the lens of contemporary realities. The research employed methods of analysis of scientific and pedagogical literature, comparison, systematisation, and generalisation of scientific approaches to the study of the problem. The study identified the goals of pedagogical practice, which include consolidating the theoretical knowledge acquired during studies, familiarising students with all aspects of their future profession, developing the ability to make independent, well-considered decisions in specific professional conditions, fostering the capacity for self-development and self-improvement, systematically deepening and applying one's knowledge, and mastering modern traditional and innovative methods by higher education students. Additionally, the article outlined the tasks of pedagogical practice within the system of higher education training, and substantiates its impact on the formation of professional competence, as pedagogical practice is instrumental in self-realisation, mobilising personal potential, and revealing the abilities of future teachers. The practical value of the research lies in its potential use by practice supervisors, faculty managers, methodologists, administrators, and teachers of general secondary education institutions, as well as higher education students in the system of practical training
Didactic principles of implementation of mixed forms of education in the educational environment of educational institutions
Authors: Bahno Yuliia , Serhiichuk Olena
Published: January 2025

Blended learning under martial law makes it possible to create an educational process that takes into account the individual needs of students, develops their critical thinking and helps to ensure a high level of learning outcomes, thanks to the creative approach of the teaching staff. The success of blended learning implementation depends on the creativity and pedagogical skills of the teacher. The purpose of the article was to study the experience of implementing blended learning, to study its didactic principles of implementation in educational institutions and to study its characteristics. The study involved an analysis of scientific literature, including articles, dissertation research, books and conference proceedings. The didactic foundations for the implementation of blended learning at the present stage are the achievement of learning outcomes by defining clear educational objectives; organisation of the educational process in the interests of the intellectual development of students on the way to implementing a personal educational trajectory; introduction of innovative teaching methods for the development of professional competence and relevant professional qualities of future specialists. At the same time, it was stated that the educational and methodological framework for the implementation of the educational process is not sufficiently developed, which creates the following problems: a significant burden on teachers due to the careful planning of each stage of the lesson, selection and systematisation of educational and methodological materials, methods and forms of work, which contributes to increased anxiety of both teachers and students. The results of this study can be used by educational institutions to optimise the process of implementing blended learning, especially in martial law