bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insights to Regulation of Fructose-1,6-bisphosphatase during Anoxia in Red-Eared Slider, Trachemys scripta elegans
Authors: Gupta Aakriti , Varma Anchal , Storey Kenneth B.
Published: October 2021

The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions.
Aberrant Learned Irrelevance in Patients with First-Episode Schizophrenia-Spectrum Disorder
Authors: Chu Ryan Sai-Ting , Ng Chung-Mun , Chan Kwun-Nam , Chan Kit-Wa , Lee Ho-Ming , Hui Lai-Ming , Chen Eric , Chang Wing-Chung
Published: October 2021

Emerging evidence has indicated disrupted learned irrelevance (LIrr), a form of selective attention deficit that may contribute to psychotic symptom formation, in schizophrenia. However, previous research mostly focused on chronic patients. There is a paucity of studies on LIrr in first-episode schizophrenia-spectrum disorder (i.e., schizophrenia and schizophreniform disorder; FES), which were limited by small sample size and have produced mixed results. The current study examined a LIrr effect and its relationship with positive symptom severity in 40 briefly-medicated FES patients and 42 demographically-matched healthy controls using a well-validated computerized LIrr paradigm which has been applied in chronic schizophrenia sample. Positive symptoms were assessed by Positive and Negative Syndrome Scale (PANSS) and Psychotic Symptom Rating Scales (PSYRATS). Our results showed that controls demonstrated intact LIrr, with significantly faster learning about previously predictive (relevant) than previously non-predictive (irrelevant) cues. Lack of such normal attention bias towards predictive over non-predictive cues was observed in FES patients, indicating their failure to distinguish between relevant and irrelevant stimuli. Nonetheless, we failed to reveal any significant correlations between learning scores, in particular learning scores for non-predictive cues, and positive symptom measures in FES patients. Learning scores were also not associated with other symptom dimensions, cognitive functions and antipsychotic dose. In conclusion, our findings indicate aberrant LIrr with impaired allocation of attention to relevant versus irrelevant stimuli in briefly-medicated FES patients. Further prospective research is warranted to clarify the longitudinal trajectory of such selective attention deficit and its association with positive symptoms and treatment response in the early course of illness.
Occurrence of Sinonasal Intestinal-Type Adenocarcinoma and Non-Intestinal-Type Adenocarcinoma in Two Countries with Different Patterns of Wood Dust Exposure
Authors: Leivo Ilmo , Holmila Reetta , Luce Danièle , Steiniche Torben , Dictor Michael , Heikkilä Pirjo , Husgafvel-Pursiainen Kirsti , Wolff Henrik
Published: October 2021

Sinonasal intestinal-type adenocarcinoma is strongly associated with hardwood dust exposure. Non-intestinal-type adenocarcinoma is a rarer and less well-known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non-intestinal adenocarcinomas were more common than intestinal-type adenocarcinomas (12 non-intestinal vs. nine intestinal), while in the French samples the reverse was true (six non-intestinal vs. 29 intestinal). Such remarkably dissimilar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma.
Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery
Authors: Fachim Helene A. , Iqbal Zohaib , Gibson J. Martin , Baricevic-Jones Ivona , Campbell Amy E. , Geary Bethany , Syed Akheel A. , Whetton Antony , Soran Handrean , Donn Rachelle P. , Heald Adrian H.
Published: October 2021

Severe obesity is a disease associated with multiple adverse effects on health. Metabolic bariatric surgery (MBS) can have significant effects on multiple body systems and was shown to improve inflammatory markers in previous short-term follow-up studies. We evaluated associations between changes in inflammatory markers (CRP, IL6 and TNFα) and circulating proteins after MBS. Methods: Sequential window acquisition of all theoretical mass spectra (SWATH-MS) proteomics was performed on plasma samples taken at baseline (pre-surgery) and 6 and 12 months after MBS, and concurrent analyses of inflammatory/metabolic parameters were carried out. The change in absolute abundances of those proteins, showing significant change at both 6 and 12 months, was tested for correlation with the absolute and percentage (%) change in inflammatory markers. Results: We found the following results: at 6 months, there was a correlation between %change in IL-6 and fold change in HSPA4 (rho = −0.659; p = 0.038) and in SERPINF1 (rho = 0.714, p = 0.020); at 12 months, there was a positive correlation between %change in IL-6 and fold change in the following proteins—LGALS3BP (rho = 0.700, p = 0.036), HSP90B1 (rho = 0.667; p = 0.05) and ACE (rho = 0.667, p = 0.05). We found significant inverse correlations at 12 months between %change in TNFα and the following proteins: EPHX2 and ACE (for both rho = −0.783, p = 0.013). We also found significant inverse correlations between %change in CRP at 12 months and SHBG (rho = −0.759, p = 0.029), L1CAM (rho = −0.904, p = 0.002) and AMBP (rho = −0.684, p = 0.042). Conclusion: Using SWATH-MS, we identified several proteins that are involved in the inflammatory response whose levels change in patients who achieve remission of T2DM after bariatric surgery in tandem with changes in IL6, TNFα and/or CRP. Future studies are needed to clarify the underlying mechanisms in how MBS decreases low-grade inflammation.
Eco-Friendly Protective Coating to Extend the Life of Art-Works and Structures Made in Porous Stone Materials
Authors: Lettieri Mariateresa , Masieri Maurizio , Aquaro Marika , Dilorenzo Debora , Frigione Mariaenrica
Published: October 2021

The application of hydrophobic treatments to stone surfaces is the most common proven method to prevent, or at least limit, the degradation of stone-made constructions and artworks brought about by the ingress and action of water, in particular in the case of very porous stone materials. To avoid the use of protective products containing harmful solvents, new green products have been proposed. In this paper, an eco-friendly hydrophobic coating, based on a fluorine polymer dispersed in water, was deeply analyzed to evaluate its protective properties, especially for very porous stone substrates. To this aim, a wide characterization of treated and untreated Lecce stone elements, i.e., a stone typical of the Apulia region, was carried out to assess the optimum required amount, the effectiveness and the protective capability, even against graffiti staining, of the green hydrophobic treatment, still allowing the stone to retain adequate vapor permeability. The efficacy of the eco-friendly product was analyzed also after a short time (four weeks) of outdoor exposure. Suitable performance and short-term durability of the green hydrophobic coating were found, comparable or even greater than those reported in the current literature for other widespread commercial products, confirming the capability of the product to preserve porous stone surfaces even in absence of solvents in its formulation. The study also allowed to experiment with the “contact sponge” test as an appropriate method for evaluating the water absorption properties of the stone.
The Trade-Offs and Synergistic Relationships between Grassland Ecosystem Functions in the Yellow River Basin
Authors: Yang Jie , Xie Baopeng , Zhang Degang
Published: October 2021

Grassland is the most important land use/cover type in the Yellow River basin. Studying its ecosystem services and the trade-off and synergistic relationships between its various functions is of great significance to high-quality development and the protection of the ecological environment in the Yellow River basin. This paper evaluates the five typical functions of grassland in the Yellow River basin quantitatively, including water yield, carbon storage, soil conservation, habitat quality, and NPP by adopting the InVEST model and the CASA model. It analyzes changes in the trade-offs and the synergistic relationships between the five ecosystem functions from 1990 to 2018 by adopting the correlation coefficient method. The paper also analyzes and explores the spatial heterogeneity of the trade-offs and synergistic relationships by adopting the bivariate spatial autocorrelation method. The results show that from 1990 to 2018, the average water yield depth, carbon storage, and NPP of the grassland in the Yellow River basin tended to increase; soil conservation and habitat quality showed a decreasing trend; and the spatial distribution of the five functions were clearly in line with zonal law. The five ecological functions were synergistic; the synergistic relationship between water yield and the other functions was relatively weak, and there was a strong synergistic relationship between the other four functions. The trade-offs and synergistic relationships between the five functions demonstrated significant spatial heterogeneity in space. This research provides a scientific basis for determining the optimal utilization and sustainable development of grassland resources.
Comparison of Magnifying Endoscopy with Blue Light Imaging and Narrow Band Imaging for Determining the Invasion Depth of Superficial Esophageal Squamous Cell Carcinoma by the Japanese Esophageal Society’s Intrapapillary Capillary Loop Classification
Authors: Hatta Waku , Koike Tomoyuki , Ogata Yohei , Kondo Yutaka , Ara Nobuyuki , Uno Kaname , Asano Naoki , Imatani Akira , Masamune Atsushi
Published: October 2021

Blue light imaging (BLI) and narrow-band imaging (NBI) are two modalities that enable narrow-band light observation. We aimed to compare the diagnostic ability of magnifying endoscopy with BLI (ME-BLI) and NBI (ME-NBI) for determining the invasion depth of superficial esophageal squamous cell carcinoma (SESCC) by the Japanese Esophageal Society’s intrapapillary capillary loop (IPCL) classification. We enrolled 81 patients between 2014 and 2018, and the still endoscopic images for diagnosing the invasion depth at the same part in ME-BLI and ME-NBI were registered. Two blinded investigators reviewed them and diagnosed the invasion depth by the IPCL classification. Subsequently, the diagnostic yields in two modalities were compared. The overall accuracies for the invasion depth by the IPCL classification in ME-BLI and ME-NBI did not differ significantly (67.9–71.6% vs. 72.8–74.1%). In the analysis based on the invasion depth, the sensitivities and positive predictive values in tumors invading the muscularis mucosa or submucosa ≤200 µm were low (23.1–30.8% and 16.7–25.0%, respectively) in both modalities. In conclusion, the diagnostic ability for determining the invasion depth of SESCC by the IPCL classification was relatively similar in ME-BLI and ME-NBI, but diagnosis by magnifying endoscopy alone might not be satisfactory.
Identifying Peripheral Neuropathy in Colour Fundus Photographs Based on Deep Learning
Authors: Cervera Diego R. , Smith Luke , Diaz-Santana Luis , Kumar Meenakshi , Raman Rajiv , Sivaprasad Sobha
Published: October 2021

The aim of this study was to develop and validate a deep learning-based system to detect peripheral neuropathy (DN) from retinal colour images in people with diabetes. Retinal images from 1561 people with diabetes were used to predictDN diagnosed on vibration perception threshold. A total of 189 had diabetic retinopathy (DR), 276 had DN, and 43 had both DR and DN. 90% of the images were used for training and validation and 10% for testing. Deep neural networks, including Squeezenet, Inception, and Densenet were utilized, and the architectures were tested with and without pre-trained weights. Random transform of images was used during training. The algorithm was trained and tested using three sets of data: all retinal images, images without DR and images with DR. Area under the ROC curve (AUC) was used to evaluate performance. The AUC to predict DN on the whole cohort was 0.8013 (±0.0257) on the validation set and 0.7097 (±0.0031) on the test set. The AUC increased to 0.8673 (±0.0088) in the presence of DR. The retinal images can be used to identify individuals with DN and provides an opportunity to educate patients about their DN status when they attend DR screening.
The Effects of COVID-19 in the Learning Process of Primary School Students: A Systematic Review
Authors: Sánchez Amate José Jesús , Luque de la Rosa Antonio , Gutiérrez Cáceres Rafaela , Vargas Serrano Alejandro
Published: October 2021

(1) Background: A variety of social and economic changes are happening worldwide due to the pandemic caused by COVID-19, which has produced new problems and challenges for the population as a whole. These events demand new investigations and key studies for their management. This review addresses the repercussions of COVID-19 at the educational level in the primary education stage, delving into the effects produced in teaching and different aspects related to it, such as the situation and challenges of teachers, family involvement, and the perceptions and repercussions of the learning and socio-educational development of students (especially in the case of students with Autism Spectrum Disorder). (2) Methods: The methodological design is a systematic review study, following the PRISMA guidelines, from a search carried out during the month of July 2021 in the Scopus, Dialnet, and WoS databases on the object of study. (3) Results: The selected studies were analyzed through a qualitative content analysis based on a population of 103 articles, with a final sample of 13, using the inclusion criteria: empirical studies or research in English or Spanish; free access through the Internet; categories restricted to “education/educational research” related to the proposed objectives; specific documents of the primary education stage and/or students with Autism Spectrum Disorder. (4) Conclusions: The research reveals the presence of an existing digital gap in certain sectors of the student population aggravated by the pandemic, as well as the scarcity of general teacher training in this type of situation, leading to different personal and professional problems that hinder teaching and emphasize the vulnerability of the right to education, which leads to further promoting the already existing social inequalities.
Advanced AI Hardware Designs Based on FPGAs
Authors: Kim Joo-Young
Published: October 2021

Artificial intelligence (AI) and machine learning (ML) technology enable computers to run cognitive tasks such as recognition, understanding, and reasoning, which are believed to be processes that only humans are capable of, using a massive amount of data [...]
The Impact of Air Pollution on the Growth of Scots Pine Stands in Poland on the Basis of Dendrochronological Analyses
Authors: Chojnacka-Ożga Longina , Ożga Wojciech
Published: October 2021

The aim of this study was to evaluate Scots pine stand degradation caused by the pollutants emitted from Zakłądy Azotowe Puławy, one of the biggest polluters of the environment in Poland for over 25 years (1966–1990). To assess the pollution stress in trees, we chose the dendrochronological analysis We outlined three directions for our research: (i) the spatio-temporal distribution of the growth response of trees to the stress associated with air pollution; (ii) the direct and indirect effects of air pollution which may have influenced the growth response of trees; and (iii) the role of local factors, both environmental and technological, in shaping the growth response of trees. Eight Scots pine stands were selected for study, seven plots located in different damage zones and a reference plot in an undamaged stand. We found that pollutant emission caused disturbances of incremental dynamics and long-term strong reduction of growth. A significant decrease in growth was observed for the majority of investigated trees (75%) from 1966 (start of factory) to the end of the 1990s. The zone of destruction extended primarily in easterly and southern directions, from the pollution source, associated with the prevailing winds of the region. At the end of the 1990s, the decreasing trend stopped and the wider tree-rings could be observed. This situation was related to a radical reduction in ammonia emissions and an improvement in environmental conditions. However, the growth of damaged trees due to the weakened health condition is lower than the growth of Scots pine on the reference plot and trees are more sensitive to stressful climatic conditions, especially to drought.
Effects of Intercropping on Fractal Dimension and Physicochemical Properties of Soil in Karst Areas
Authors: Xu Qinqin , Xiong Kangning , Chi Yongkuan
Published: October 2021

Suitable soil structure and nutrient security are important for plant growth and development. The fractal dimension of soil, along with the distribution of physical and chemical properties and their interactions, plays an important role in studying the stability of soil structures and water and fertilizer cycles. As a sustainable management model, intercropping has positive benefits for erosion control, the spatial optimization of resources, and improving system productivity. The effects of four intercropping methods on the fractal dimension and physicochemical properties of soil were investigated by intercropping Salvia miltiorrhiza with forage and S. miltiorrhiza with forest under typical karst rock desertification habitats in Guizhou. The results showed that the soil nutrient content when intercropping was significantly higher than that of monoculture. The organic carbon content of soil grown under forest is higher than other treatments, and there was a non-significant change in soil water content when intercropping compared with monoculture. The soil fine-grained matter when intercropping was significantly higher than that of monoculture, while the soil fractal dimension showed a tendency to become larger with an increase in fine-grained matter. Intercropping planting, due to its component types and spatial and temporal configurations, leads to differences in soil water and fertilizer interactions, which can be combined with other ecological restoration measures to optimize the composite model and jointly promote the restoration and development of ecologically fragile areas.
Velocity Profile Representation for Fully Developed Turbulent Flows in Pipes: A Modified Power Law
Authors: Salama Amgad
Published: October 2021

In the design practices of many engineering applications, gross information about the flow field may suffice to provide magnitudes of the parameters that are essential to complete the design with reasonable accuracy. If such design parameters can be estimated following simpler steps, it may be possible to abandon the need to conduct expensive numerical and/or experimental works to produce them. In this work, we are interested in providing a generalized power law that depicts the velocity profile for fully developed turbulent flows. This law incorporates two fitting parameters m and n that represent the exponents of (1) a nondimensional length scale and (2) an overall exponent, respectively. These two parameters may be determined by fitting the experimental and/or computational data. In this work, fitting benchmark experimental and computational fluid dynamics (CFD) data found in the literature reveals that the parameter m changes over a relatively smaller range (between 1 and 2), while the parameter n changes over a wider range (between 1 and 12 for the range of Reynolds number considered). These two parameters (m and n) are, generally, not universal, and they depend on the Reynolds number (Re). A correlation was also developed to correlate n and Re in the turbulent flow region. In order to preserve the continuity of the derivative of the velocity profile at the centerline, a value of m equals 2 over the whole range of Re is recommended. Apart from the near wall area, the new law fits the velocity profile reasonably well. This generalized law abides to a number of favorable stipulations for the velocity profile, namely the continuity of derivatives and reduction to the laminar flow velocity profile for lower values of Re.
Mitochondrial Strokes: Diagnostic Challenges and Chameleons
Authors: Pizzamiglio Chiara , Bugiardini Enrico , Macken William L. , Woodward Cathy E. , Hanna Michael G. , Pitceathly Robert D. S.
Published: October 2021

Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). They should be suspected in anyone with an acute/subacute onset of focal neurological symptoms at any age and are usually driven by seizures. Suggestive features of an underlying mitochondrial pathology include evolving MRI lesions, often originating within the posterior brain regions, the presence of multisystemic involvement, including diabetes, deafness, or cardiomyopathy, and a positive family history. The diagnosis of MELAS has important implications for those affected and their relatives, given it enables early initiation of appropriate treatment and genetic counselling. However, the diagnosis is frequently challenging, particularly during the acute phase of an event. We describe four cases of mitochondrial strokes to highlight the considerable overlap that exists with other neurological disorders, including viral and autoimmune encephalitis, ischemic stroke, and central nervous system (CNS) vasculitis, and discuss the clinical, laboratory, and imaging features that can help distinguish MELAS from these differential diagnoses.
Genetically Predicted Type 2 Diabetes Mellitus Liability, Glycated Hemoglobin and Cardiovascular Diseases: A Wide-Angled Mendelian Randomization Study
Authors: Liu Bowen , Mason Amy M. , Sun Luanluan , Di Angelantonio Emanuele , Gill Dipender , Burgess Stephen
Published: October 2021

(1) Aim: To investigate the causal effects of T2DM liability and glycated haemoglobin (HbA1c) levels on various cardiovascular disease outcomes, both in the general population and in non-diabetic individuals specifically. (2) Methods: We selected 243 variants as genetic instruments for T2DM liability and 536 variants for HbA1c. Linear Mendelian randomization analyses were performed to estimate the associations of genetically-predicted T2DM liability and HbA1c with 12 cardiovascular disease outcomes in 367,703 unrelated UK Biobank participants of European ancestries. We performed secondary analyses in participants without diabetes (HbA1c < 6.5% with no diagnosed diabetes), and in participants without diabetes or pre-diabetes (HbA1c < 5.7% with no diagnosed diabetes). (3) Results: Genetically-predicted T2DM liability was positively associated (p < 0.004, 0.05/12) with peripheral vascular disease, aortic valve stenosis, coronary artery disease, heart failure, ischaemic stroke, and any stroke. Genetically-predicted HbA1c was positively associated with coronary artery disease and any stroke. Mendelian randomization estimates generally shifted towards the null when excluding diabetic and pre-diabetic participants from analyses. (4) Conclusions: This genetic evidence supports causal effects of T2DM liability and HbA1c on a range of cardiovascular diseases, suggesting that improving glycaemic control could reduce cardiovascular risk in a general population, with greatest benefit in individuals with diabetes.
Expanding the Phenotype of the FAM149B1-Related Ciliopathy and Identification of Three Neurogenetic Disorders in a Single Family
Authors: Siegert Sandy , Mindler Gabriel T. , Brücke Christof , Kranzl Andreas , Patsch Janina , Ritter Markus , Janecke Andreas R. , Vodopiutz Julia
Published: October 2021

Biallelic truncating FAM149B1 variants result in cilia dysfunction and have been reported in four infants with Joubert syndrome and orofaciodigital syndrome type VI, respectively. We report here on three adult siblings, 18 to 40 years of age, homozygous for the known FAM149B1 c.354_357delinsCACTC (p.Gln118Hisfs*20) variant. Detailed clinical examinations were performed including ocular and gait analyses, skeletal- and neuroimaging. All three patients presented with neurological and oculomotor symptoms since birth and mild skeletal dysplasia in infancy resulting in characteristic gait abnormalities. We document mild skeletal dysplasia, abnormal gait with increased hip rotation and increased external foot rotation, ataxia, variable polydactyly, ocular Duane syndrome, progressive ophthalmoplegia, nystagmus, situs inversus of the retinal vessels, olfactory bulb aplasia, and corpus callosal dysgenesis as novel features in FAM149B1-ciliopathy. We show that intellectual disability is mild to moderate and retinal, renal and liver function is normal in these affected adults. Our study thus expands the FAM149B1-related Joubert syndrome to a mainly neurological and skeletal ciliopathy phenotype with predominant oculomotor dysfunction but otherwise stable outcome in adults. Diagnosis of FAM149B1-related disorder was impeded by segregation of multiple neurogenetic disorders in the same family, highlighting the importance of extended clinical and genetic studies in families with complex phenotypes.
Dynamic Metasomatism Experiments Investigating the Interaction between Migrating Potassic Melt and Garnet Peridotite
Authors: Foley Stephen , Pertermann Maik
Published: October 2021

Dynamic metasomatism experiments were performed by reacting a lamproite melt with garnet peridotite by drawing melt through the peridotite into a vitreous carbon melt trap, ensuring the flow of melt through the peridotite and facilitating analysis of the melt. Pressure (2–3 GPa) and temperature (1050–1125 °C) conditions were chosen where the lamproite was molten but the peridotite was not. Phlogopite was formed and garnet and orthopyroxene reacted out, resulting in phlogopite wehrlite (2 GPa) and phlogopite harzburgite (3 GPa). Phlogopites in the peridotite have higher Mg/(Mg + Fe) and Cr2O3 and lower TiO2 than in the lamproite due to buffering by peridotite minerals, with Cr2O3 from the elimination of garnet. Compositional trends in phlogopites in the peridotite are similar to those in natural garnet peridotite xenoliths in kimberlites. Changes in melt composition resulting from the reaction show decreased TiO2 and increased Cr2O3 and Mg/(Mg + Fe). The loss of phlogopite components during migration through the peridotite results in low K2O/Na2O and K/Al in melts, indicating that chemical characteristics of lamproites are lost through reaction with peridotite so that emerging melts would be less extreme in composition. This indicates that lamproites are unlikely to be derived from a source rich in peridotite, and more likely originate in a source dominated by phlogopite-rich hydrous pyroxenites. Phlogopites from an experiment in which lamproite and peridotite were intimately mixed before the experiment did not produce the same phlogopite compositions, showing that care must be taken in the design of reaction experiments.
Survival Analysis of Symptomatic COVID-19 in Phuentsholing Municipality, Bhutan
Authors: Gyeltshen Kinley , Tsheten Tsheten , Dorji Sither , Pelzang Thinley , Wangdi Kinley
Published: October 2021

COVID-19 is a disease that is caused by a highly transmissible and pathogenic novel coronavirus: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All of the COVID-19 positive cases in Bhutanese travellers returning via the Phuentsholing point of entry, the local population, and Indian nationals were isolated in the Phuentsholing COVID-19 isolation ward, Bhutan. This study aimed to identify the risk factors for developing symptoms among COVID-19 positive patients in this ward. A retrospective cohort study was conducted using the data regarding COVID-19 positive cases in the Phuentsholing COVID-19 isolation ward from 28 May 2020 to 31 May 2021. The Cox proportional hazards regression model was used to identify the risk factors of developing COVID-19 symptoms. There were 521 patients in the study; 368 (70.6%) were males and 153 (29.4%) were females. The mean age was 32 years (with a range of 1–78 years), and 290 (56.0%) reported at least one symptom. The median length of isolation was eight days (with a range of 3–48 days). The common symptoms were: cough (162, 31.0%), fever (135, 26.0%), and headache (101, 19.0%). In the multivariable Cox regression, vaccinated patients were 77.0% (p = 0.047) less likely to develop symptoms compared to those who were not vaccinated. The front line workers and the mini-dry port (MDP) workers were 15 (p = 0.031) and 41 (p < 0.001) times more likely to be symptomatic compared to returning travellers. The young and economically active population group was most commonly affected by COVID-19. The presence of risk factors, such as being front line workers, MDP workers, or not being vaccinated against COVID-19, meant that patients had a higher probability of developing symptoms of COVID-19.
People with Disabilities in the Workplace: Results of a Survey Conducted among Polish and Finnish Employers
Authors: Grześkowiak Alicja , Załuska Urszula , Kwiatkowska-Ciotucha Dorota , Kozyra Cyprian
Published: October 2021

The key aspect of the inclusion of people with disabilities (PwD) in the workplace is how they are perceived by employers who make decisions on hiring employees. The article presents the results of CAWI (Computer Assisted Web Interview) research conducted among Polish and Finnish employers (n = 414) in 2021 using a proprietary questionnaire. Employers were asked to assess the state policy in the field of PwD’s inclusion, the social atmosphere in this respect, the level of acceptance of privileges/special solutions dedicated to PwD in the workplace and the knowledge of the specificity of disability. When analysing the obtained data, we verified the differentiation of Polish and Finnish employers’ assessments, the impact of respondents’ characteristics on their assessment and the relations between the assessments of various aspects of PwD’s inclusion. For the analysis, we used the t-test of independent samples for equality of means and the Pearson correlation coefficient. The results showed that Finnish respondents assess the conditions for the full inclusion of PwD much better than Polish ones. The characteristics most differentiating employers’ assessments is gender and the fact of employing PwD. There were also correlations between the responses of respondents in both countries to three out of four analysed questions from the questionnaire. The differences found in this study indicate that it would be worth extending the research to other European countries to generalize conclusions about the influence of cultural determinants on the situation of PwD on the labour market.
The Paradoxical Effect of Living Alone on Cognitive Reserve and Mild Cognitive Impairment among Women Aged 60+ in Mexico City
Authors: Villa Antonio R. , Guerrero Elsa , Villa Ana M. , Sánchez-Arenas Rosalinda , Ortiz-Rodríguez María Araceli , Contreras-Sánchez Vania , Alonso-Catalán María , Guerrero-López Benjamín , Vargas-Huicochea Ingrid , Fajardo-Dolci Germán E. , Díaz-Olavarrieta Claudia
Published: October 2021

An elderly person who lives alone must often be autonomous and self-sufficient in daily living activities. We explored if living alone and marital status were associated with mild cognitive impairment and low cognitive reserve in a sample of Mexican women aged 60+ attending continuing education courses using a cross-sectional design. Objective cognitive functions were assessed using the MMSE and Blessed Dementia Scale. We administered the Cognitive Reserve Questionnaire. Independence skills were assessed with the Katz index and Lawton index. Multivariate logistic regression analysis was used. We recruited 269 participants (x¯ = 69.0 ± 5.8 years). Single, widowed, separated, and divorced women comprised 73% of the participants. A third lived alone and 84% had completed high school. Mild cognitive deficit was observed among 24.5–29.0%; the upper range for cognitive reserve was 61.7%. Living alone versus living with someone was associated with cognitive impairment (OR = 0.51, p = 0.04) and with low to medium cognitive reserve (OR = 0.51, p = 0.02) after adjusting for confounding variables. Living alone was an independent factor associated with a lower probability of displaying mild cognitive impairment and a higher probability of displaying high cognitive reserve. Women living alone in this study had a more robust cognitive framework and had built their own support networks.
The Impact of Different Coping Styles on Psychological Distress during the COVID-19: The Mediating Role of Perceived Stress
Authors: Ding Yi , Fu Xinchen , Liu Rude , Hwang Jacqueline , Hong Wei , Wang Jia
Published: October 2021

The present study aimed to understand the impact of different coping methods endorsed by Chinese college students during COVID-19 through the examination of the mediating role of perceived stress. We recruited a total of 492 undergraduate students to complete an online survey from May to June 2020. The results of structural equation modeling indicated that perceived stress was a significant mediator in the association between different coping styles and psychological distress. Three coping styles, including problem-focused, adaptive emotion-focused, and maladaptive emotion-focused coping styles were all significantly correlated with psychological distress. Perceived stress significantly mediated the association between the three coping styles and psychological distress. The results indicated a full mediation model in which problem-focused coping and adaptive emotion-focused coping affected psychological distress entirely through the mediation of perceived stress. Maladaptive emotion-focused coping positively predicted perceived stress, which in turn positively predicted psychological distress through a partial mediation model. We discuss the implications of these findings and offer suggestions for future research.
Hypertensive Disorders during Pregnancy and Anthropometric Measurement of Children up to 7 Years of Age: The Hokkaido Birth Cohort Study in Japan
Authors: Poudel Kritika , Kobayashi Sumitaka , Miyashita Chihiro , Yamaguchi Takeshi , Tamura Naomi , Ikeda-Araki Atsuko , Ait Bamai Yu , Itoh Sachiko , Yamazaki Keiko , Masuda Hideyuki , Itoh Mariko , Kishi Reiko
Published: October 2021

Hypertensive disorders during pregnancy (HDP) increase the risk of offspring with a low birth weight, preterm birth and small-for-gestational age; however, evidence of the anthropometric measurements during early childhood remains limited. We aimed to understand the associations between maternal HDP and anthropometric measurements of children aged up to seven years in a Japanese cohort. In total, 20,926 mother–infant pairs participated in the Hokkaido Study on Environment and Children’s Health, Japan, from 2002 to 2013. Medical reports were used to confirm HDP exposure, while weight, height, height z score, and weight z score were the outcomes. The prevalence of HDP in the study population was 1.7%. The birth height of male children born to HDP mothers was smaller as compared to those born to non-HDP mothers. When adjusted with covariates, the linear regressions showed significant changes in birth weight (β: −79.3; 95% confidence interval [CI]: −154.8, −3.8), birth height (−0.67; 95% CI: −1.07, −0.26), weight at seven years (1.21; 95% CI: 0.13, 2.29), and weight gain between four and seven years (1.12; 95% CI: 0.28, 1.96) of male children exposed to HDP. Differences were more significant in male children than female. Our study showed that despite low birth weight, male children exposed to HDP caught up with their growth and gained more weight by seven years of age compared with male children not exposed to HDP, whereas no such differences were observed in female children; however, this finding requires replication.
Differential Expression of the Apolipoprotein AI Gene in Spotnape Ponyfish (Nuchequula nuchalis) Inhabiting Different Salinity Ranges at the Top of the Estuary and in the Deep-Bay Area of Gwangyang Bay, South Korea
Authors: Park Kiyun , Kim Won-Seok , Choi Bohyung , Kwak Ihn-Sil
Published: October 2021

Spotnape ponyfish (Nuchequula nuchalis) is a dominant species that is broadly distributed from estuarine to deep-bay areas, reflecting a euryhaline habitat. Apolipoprotein AI (ApoAI) is a main component of plasma lipoproteins and has crucial roles in lipid metabolism and the defense immune system. In this study, we characterized the N. nuchalis ApoAI gene and analyzed the expression of the ApoAI transcript in N. nuchalis collected at various sites in the estuary and the deep-bay area which have different salinities. Owing to the fish’s mobility, we conducted stable isotope analyses to confirm the habitat characteristics of N. nuchalis. Carbon and nitrogen isotope ratios (δ13C and δ15N) from N. nuchalis indicated different feeding sources and trophic levels in the estuarine and deep-bay habitats. The characterized N. nuchalis ApoAI displayed residual repeats that formed a pair of alpha helices, indicating that the protein belongs to the apolipoprotein family. In the phylogenetic analysis, there was no sister group of N. nuchalis ApoAI among the large clades of fish species. The transcriptional expression level of ApoAI was higher in N. nuchalis inhabiting the deep-bay area with a high salinity (over 31 psu) than in N. nuchalis inhabiting the top of the estuary with a low salinity (6~15 psu). In addition, the expression patterns of N. nuchalis ApoAI were positively correlated with environmental factors (transparency, pH, TC, and TIC) in the high salinity area. These results suggest that ApoAI gene expression can reflect habitat characteristics of N. nuchalis which traverse broad salinity ranges and is associated with functional roles of osmoregulation and lipid metabolism for fish growth and development.
Indoor Dining and In-Person Learning: A Comparison of 30 US Cities
Authors: O’Leary Gabriella , Schnake-Mahl Alina S. , Vaidya Vaishnavi , Bilal Usama , Kolker Jennifer
Published: October 2021

With limited US federal leadership on closing and re-opening strategies to mitigate the COVID-19 pandemic, cities and states were left to enact their own policies. This article examines two key sets of policies—in-person learning in public elementary schools and indoor dining—across 30 of the largest US cities in the summer, fall, and winter of 2020. We review indoor dining and in-person elementary education policy decisions between 1 May 2020 and 14 December 2020 across 30 US cities. We review the public health evidence, political power, and jurisdictional challenges that cities faced, and the policy implications of these factors. Overwhelmingly, indoor dining re-opened in cities while in-person elementary schools were kept closed; indoor dining re-opened in all cities in fall 2020, while only 40% of public elementary schools re-opened for in-person instruction. Looking ahead to fully bringing students back for in-person learning, and considering future potential community outbreaks, this retrospective analysis can help inform city and state governments on policy decisions around indoor dining and reopening/closing schools for in-person learning.
Boosting Numerical Cognition in Children and Adolescents with Mathematical Learning Disabilities by a Brain-Based Intervention: A Study Protocol for a Randomized, Sham-Controlled Clinical Trial
Authors: Lazzaro Giulia , Battisti Andrea , Varuzza Cristiana , Celestini Laura , Pani Pierpaolo , Costanzo Floriana , Vicari Stefano , Kadosh Roi Cohen , Menghini Deny
Published: October 2021

Numbers are everywhere, and supporting difficulties in numerical cognition (e.g., mathematical learning disability (MLD)) in a timely, effective manner is critical for their daily use. To date, only low-efficacy cognitive-based interventions are available. The extensive data on the neurobiology of MLD have increased interest in brain-directed approaches. The overarching goal of this study protocol is to provide the scientific foundation for devising brain-based and evidence-based treatments in children and adolescents with MLD. In this double-blind, between-subject, sham-controlled, randomized clinical trial, transcranial random noise stimulation (tRNS) plus cognitive training will be delivered to participants. Arithmetic, neuropsychological, psychological, and electrophysiological measures will be collected at baseline (T0), at the end of the interventions (T1), one week (T2) and three months later (T3). We expect that tRNS plus cognitive training will significantly improve arithmetic measures at T1 and at each follow-up (T2, T3) compared with placebo and that such improvements will correlate robustly and positively with changes in the neuropsychological, psychological, and electrophysiological measures. We firmly believe that this clinical trial will produce reliable and positive results to accelerate the validation of brain-based treatments for MLD that have the potential to impact quality of life.
The Relationship of the Information Quantity of Urban Roadside Traffic Signs and Drivers’ Visibility Based on Information Transmission
Authors: Liu Kun , Deng Hongxing
Published: October 2021

For the lack of quantitative basis of traffic sign combination information, this paper established a model of information quantity of urban road traffic signs by analyzing the driver’s information processing and the visual recognition of traffic signs combined with theories of informatics. It used various analytical methods to build a model of the relationship between the traffic sign information quantity (TSIQ) and the driver’s visual recognition. Based on factors, the relationship between the TSIQ and the driver’s visual recognition was studied and analyzed to provide a reference for the design of urban traffic sign layout information. The results show that the TSIQ can explain 61% of the driver’s recognition time (DRT). The more information the road traffic sign conveys, the longer DRT will be. The TSIQ’s threshold is 642 bits, and exceeding this value will cause information overload. Different influence factors have a certain impact on drivers’ visual recognition distance (VRD). The male VRD is shorter than the female. The VRD of the young driver is larger than the old driver. The VRD of a novice driver is longer than an experienced driver, while the visual recognition sign of an experienced driver is shorter.
Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet
Authors: Son Hee-Kyoung , Xiang Huo , Park Seohyun , Lee Jisu , Lee Jae-Joon , Jung Sunyoon , Ha Jung-Heun
Published: October 2021

In this study, we investigated whether the partial replacement of dietary fat with polyunsaturated fatty acids (PUFAs) ameliorated the lipopolysaccharide (LPS)-induced hepatic inflammation in rats fed a high-fat diet. Male Sprague-Dawley rats were divided into three groups and provided each of the following diets: (1) high-fat diet (HFD), (2) HFD with perilla oil (PO), and (3) HFD with corn oil (CO). After 12 weeks of dietary intervention, the rats were intraperitoneally injected with LPS (5 mg/kg) from Escherichia coli O55:B5 or phosphate-buffered saline (PBS). Following LPS stimulation, serum insulin levels were increased, while PO and CO lowered the serum levels of glucose and insulin. In the liver, LPS increased the triglyceride levels, while PO and CO alleviated the LPS-induced hepatic triglyceride accumulation. In the LPS injected rats, the mRNA expression of genes related to inflammation and endoplasmic reticulum (ER) stress was attenuated by PO and CO in the liver. Furthermore, hepatic levels of proteins involved in the nuclear factor kappa-light-chain-enhancer of activated B cells/mitogen-activated protein kinase pathways, antioxidant response, and ER stress were lowered by PO- and CO-replacement. Therefore, the partial replacement of dietary fat with PUFAs alleviates LPS-induced hepatic inflammation during HFD consumption, which may decrease metabolic abnormalities.
Snacking on Almonds Lowers Glycaemia and Energy Intake Compared to a Popular High-Carbohydrate Snack Food: An Acute Randomised Crossover Study
Authors: Brown Rachel , Ware Lara , Gray Andrew R. , Chisholm Alex , Tey Siew Ling
Published: October 2021

Consuming nuts may have advantages over other snack foods for health and body-weight regulation. Suggested mechanisms include increased satiety and lower glycaemia. We used an acute randomised crossover trial to assess glycaemic and appetite responses to consuming two isocaloric snacks (providing 10% of participants’ total energy requirements or 1030 kJ (equivalent to 42.5 g almonds), whichever provided greater energy): raw almonds and sweet biscuits among 100 participants with available data (25 males and 75 females) following 106 being randomised. Two hours after consuming a standardised breakfast, participants consumed the snack food. Finger-prick blood samples measuring blood glucose and subjective appetite ratings using visual analogue scales were taken at baseline and at 15 or 30 min intervals after consumption. Two hours after snack consumption, an ad libitum lunch was offered to participants and consumption was recorded. Participants also recorded food intake for the remainder of the day. The mean area under the blood glucose response curve was statistically and practically significantly lower for almonds than biscuits (mean (95% CI) difference: 53 mmol/L.min (45, 61), p < 0.001). Only the composite appetite score at 90 min was higher in the almond treatment compared to the biscuit treatment (45.7 mm vs. 42.4 mm, p = 0.035 without adjustment for multiple comparisons). There was no evidence of differences between the snacks for all other appetite ratings or for energy intake at the ad libitum lunch. However, mean energy intakes following snack consumption were significantly lower, both statistically and in practical terms, for the almond treatment compared to the biscuit (mean (95% CI) diff: 638 kJ (44, 1233), p = 0.035). Replacing popular snacks with almonds may have advantages in terms of glycaemia and energy balance.