bluuebunny/crossref_metadata_2025 huggingface dataset:
Jurisprudencia nacional reciente en materia de asilo
Authors: Villafáñez Gallego Rafael
Published: October 2024

La materia de asilo ha merecido tradicionalmente la atención de la jurisprudencia de la Sala Tercera del Tribunal Supremo. El presente trabajo tiene por objeto analizar cómo ha incidido en dicha jurisprudencia la reforma del recurso de casación operada por la Ley Orgánica 7/2015. En el análisis de dicho impacto destaca la diversidad de materias que se ha considerado por la Sección de Admisión, que presentaban interés casacional objetivo, auténtica clave de bóveda de la nueva casación en el orden contencioso-administrativo, dando lugar a una serie de pronunciamientos que han servido para ampliar el acervo jurisprudencial en la materia.
El tratamiento jurisprudencial de la mala fe en el contrato de seguro de responsabilidad civil
Authors: Men�ndez Est�banez Francisco Javier
Published: October 2024

A pesar de los diversos conceptos que la Ley 50/1980, de 8 de octubre, de Contrato de Seguro utiliza para referirse a actuaciones contrarias a la buena fe, la mala fe es equivalente al dolo civil. En consecuencia, estas expresiones relativas a la mala fe, al dolo, a la provocaci�n intencionada y similares se refieren a un elemento intencional definido, pues se refieren a actuaciones conscientes y voluntarias que se proyectan sobre concretos elementos obligacionales del contrato de seguro. La regla general es la inasegurabilidad del dolo. Sin embargo, en el �mbito del seguro de responsabilidad civil, se produce de facto la cobertura del riesgo a fin de proteger al perjudicado.
La posici�n del tercero perjudicado: oponibilidad de excepciones y apariencia de inmunidad
Authors: Pe�as Moyano Mar�a Jes�s
Published: October 2024

El escaso r�gimen jur�dico existente sobre las posibilidades de ejercitar la acci�n directa por parte del tercero perjudicado, as� como sobre los l�mites en los que esta actuaci�n se puede llevar a cabo, ha obligado a los aplicadores del derecho a establecer pautas al respecto. Cuestiones tan elementales como qui�n debe y puede ser considerado tercero perjudicado, la propia existencia de la acci�n para reclamar o la imposibilidad de su ejercicio por no apreciarse los elementos necesarios para ello, han de revisarse y aclararse en funci�n del caso concreto. La pr�ctica pone de manifiesto un recorte de la inmunidad de la acci�n directa en el contexto de las posibles excepciones que se pueden o no se pueden oponer. La necesidad de proteger al tercero perjudicado de buena fe reclama una delimitaci�n m�s adecuada de sus posibilidades de actuaci�n frente a la entidad aseguradora y tambi�n frente al asegurado.
Aspectos cr�ticos del seguro D and O y su tratamiento en la jurisprudencia
Authors: Guerrero Lebr�n Mar�a Jes�s
Published: October 2024

Los seguros D&O cubren la responsabilidad de administradores, directivos y otros cargos asimilados en sociedades de muy diverso tipo. Tra�dos inicialmente de la pr�ctica anglosajona, est�n afianzados en nuestro derecho. Sus p�lizas suelen constar de tres partes: la primera contempla la cobertura de diversas responsabilidades de los directivos; la segunda regula el reembolso a la sociedad en los casos en que esta asuma la responsabilidad, y la tercera estipula las coberturas de defensa jur�dica. Todas ellas plantean innumerables cuestiones jur�dicas de gran trascendencia pr�ctica. Por una parte, est� el tema de los distintos tipos de responsabilidad que se puede reclamar a estos sujetos (que no siempre tiene naturaleza indemnizatoria y que puede abarcar varias jurisdicciones), cuya cobertura por estas p�lizas no resulta pac�fica. Por otra parte, suelen ser seguros colectivos suscritos por la sociedad tomadora por cuenta ajena, y tambi�n ello genera situaciones conflictivas. Adem�s, la necesidad de hacer frente a demandas planteadas en momento distinto al que ocurre el evento del que traen su causa, y que estas se diluciden en procesos de larga duraci�n, hace que su cobertura temporal resulte especialmente compleja. En los �ltimos a�os, la evoluci�n normativa ha endurecido la responsabilidad de los directivos, que pueden ser objeto de sanciones en muchos de los sectores regulados, por lo que la posible cobertura de dichas sanciones es una de las que m�s inter�s suscitan. Asimismo, estos directivos tambi�n pueden ser sujetos activos de diversos delitos, lo que exige analizar c�mo resuelve la jurisprudencia la inasegurabilidad del dolo y la inmunidad de la acci�n directa, no solo respecto a las indemnizaciones que, como consecuencia de la responsabilidad civil derivada de delito, se les puede imponer en dichos procesos, sino tambi�n respecto a las correspondientes coberturas de defensa.
Titularidad de dominio público y competencias: en particular el dominio público marítimo-terrestre
Authors: García Pérez Marta María
Published: October 2024

A partir de la doctrina del Tribunal Constitucional y de los principales estudios sobre el litoral, se realiza un análisis acerca del régimen competencial concurrente sobre el dominio público marítimo-terrestre. Este análisis incluye el estudio de una ley muy reciente, elaborada desde una visión integrada y ecosistémica del litoral, la Ley 4/2023, de 6 de julio, de Ordenación y Gestión Integrada del Litoral de Galicia.
Deconstructing the Complex Network of Student Satisfaction in Open and Distance Learning: An Application of Structural Equation Modeling
Authors: CHEN MENGYING , Mohammed Lubna Ali
Published: October 2024

The rapid spread of open and distance learning (ODL) in higher education has sparked a strong interest in the determinants of student satisfaction. Although previous studies have explored various factors that influence satisfaction, a comprehensive model integrating multiple dimensions is still lacking. This study proposes and empirically tests a comprehensive structural equation model of ODL student satisfaction, incorporating interaction, instructor quality, learning management system (LMS), assessment, and student self-regulation as key predictors. Based on constructivist, collaborative, and cognitive information processing theories, we hypothesize direct effects and mediation relationships between these constructs. Data collected from 1,450 students at a large open university in China were analyzed using partial least squares structural equation modeling (PLS-SEM). The results reveal complex interrelationships among the predictors, with interaction and self-regulation emerging as key mediating variables. This study contributes to the ODL literature by providing a nuanced understanding of the satisfaction formation process and offers practical implications for improving the ODL experience. Our findings highlight the need for a holistic approach to ODL design and implementation, emphasizing the synergistic effects of technology, instructional, and personal factors in fostering student satisfaction.
An Empirical Study of Integrating Orff-Schulwerk in Music Classes to Improve College Students' Social Competence in the Post Epidemic Era
Authors: Cai Zhining , Daoruang Krisada , Posrithong Arethit
Published: October 2024

As the global epidemic eases, college students face increasing Social-Skills problems, especially when Social-Skills are reduced due to prolonged home isolation. This study investigated the effectiveness of Orff-Schulwerk in enhancing the Social-Skills of college students. Taking students of Z College School in Southern China as the research object, the current social status and needs of college students were analyzed through questionnaires and in-depth interviews. The findings suggest that Orff-Schulwerk significantly improves students' Social-Skills through its unique collective participation and creative expression, especially in enhancing teamwork, communication skills and self-confidence. This study not only provides new perspectives on the application of music education in higher education, but also provides empirical support on how to promote the development of college students' Social-Skills through art education in the post epidemic era.
Reform Strategies for the Popular Music Public Course Based on Key Competences
Authors: Huang Xiaoxia , Phokha Pramote , Chiangthong Nut
Published: October 2024

This study aims to explore the application potential of international music teaching methods in the reform of public basic courses of popular music in Chinese universities. Using mixed research methods, the applicability of Dalcroze, Kodaly, and Orff teaching methods was systematically evaluated through expert interviews, teaching material development, and a quasi-experimental design. The study found that these methods have high overall applicability in the Chinese higher education environment (average rating 4.183/5), but require localization adjustments. Based on this, the innovative textbook "Fundamentals and Applications of Popular Music" (IOC value 0.920) and a 12-week teaching plan (IOC value 0.880) were developed. The results of the 16-week teaching experiment showed that the students in the experimental group were significantly better than the control group in terms of music theory knowledge, appreciation ability, creative ability and learning interest (p<0.01). This study proposes a curriculum reform strategy that integrates innovation, technology empowerment, and interdisciplinary integration, providing theoretical basis and practical guidance for improving the quality of popular music education in colleges and universities. Future research directions include expanding the sample scope, conducting long-term follow-up studies, and deepening cross-cultural comparative analysis.
Minang Kabau Wedding Traditions: An Anthropolinguistic Study
Authors: Irhamni Mutia
Published: October 2024

The traditions of the Minang Kabau traditional wedding ceremony have cultural meanings and sociological functions that are followed from generation to generation by the Minang Kabau community. However, these traditions are not fully held by the community due to the shift of non-matrilineal culture. This study aims to explain the wedding ceremony traditions of the Minang Kabau tribe in matrilineal cultural practices. This research uses anthropological theory, where data is taken through the method of interviews (open-ended interviews), observation (observation) both participatory observation and observation-periodic to the field, and literature review (written document) This research uses qualitative methods. The data obtained were 10 people who helped implement the wedding ceremony traditions of the Minang Kabau tribe. From this research, descriptive data and explanations can be presented from the traditional wedding traditions of the Minang Kabau.The local wisdom contained in the traditional wedding traditions of the Minang Kabau is consensus in achieving goals, mutual cooperation, mutual honor between the two families and the bride and groom.
Continuity and Discontinuity in Cultural Conditioning Ruth Benedict
Authors: M. Refki Yansyah
Published: October 2024

In our culture, the human growth cycle is a constant, from vulnerable infants to adults. Ruth Benedict underscores the physiological contrast between the two, as well as the roles that change over time. While these facts of nature underlie discussions of humans, the anthropologist's role is to analyze the interaction between "nature" and human behavior, and how culture influences it. In this context, Benedict highlights the concepts of continuity and discontinuity, describing variations in child training in different cultures and differences in roles between children and adults. She points out that although physiological differences exist, the process of transitioning from child to adult varies significantly between societies. In her paper, Benedict analyzes three contracts that are prominent in culture, namely non-responsive responsible status, compliance dominance, and limited sexual roles. This research helps to understand how culture plays an important role in the formation of the human life cycle, highlighting the continuities and discontinuities that exist across different cultures.
Cross-Cultural Communication Theory
Authors: Fadhilah Nurul
Published: October 2024

Humans, influenced by their environment and culture, form diverse characters. Tolerance and openness between cultures is the key to coexistence. Joining a group brings a solution in culture, even if it conflicts with individual personalities. Dynamics and interactions between groups are needed to find a new culture, despite the potential for clashes due to cultural defenses. This phenomenon often occurs in students who migrate, facing culture shock due to cultural differences. Adjustment to the new environment is needed to overcome culture shock. Skilled adaptation communication can minimize the impact of culture shock and prevent conflict. This research uses descriptive qualitative methods with secondary data. Adaptation communication patterns of overseas students involve four stages: self-adjustment, frustration, readjustment, and development of meaningful communication. These four stages become the facility and heart of successful adaptation, improving students' communication and social relations with the campus environment.
Characterization and Prevalence of Antibiotic Resistance Staphylococcus aureus in Street Food: A Public Health Concern
Authors: Siddique Arooba , Mahmood Saher , Tahir Sadia , Tariq Izna , Shabbir Chaudhry Ahmed , Arfat Yasir
Published: October 2024

Food samples containing Staphylococcus aureus pose a serious health risk. This study aimed to examine the prevalence of S. aureus strains in various food samples sourced from Mailsi and Multan. Many food samples including yogurt, bakery products, and raw and cooked food were examined for S. aureus. The isolated strains were confirmed through Mannitol agar fermentation, catalase, coagulase, and urease tests. Hemolysis on blood agar and biofilm formation were also assessed to determine toxin production. Antibiotic sensitivity testing was conducted using the Kirby Bauer method on MH agar, and multiple antibiotics were tested. Out of all samples, a total of 50 S. aureus strains were obtained, mainly from milk and milk-based products. Yellow colonies on mannitol salt agar confirmed S. aureus presence, with all isolates testing positive for coagulase, catalase, and urease. The presence of hemolysins: beta, gamma, and alpha were revealed by hemolysis assays. Biofilm assay results showed variation among the strains, with some categorized as strong, moderate, or weak biofilm formers. Regarding antibiotic sensitivity, most strains exhibited multidrug resistance, particularly against certain antibiotics. Vancomycin showed varying susceptibility patterns, some strains showed susceptibility and intermediate resistance, whereas only milk samples showed resistance. This study emphasizes the prevalence of MDR S. aureus strains in food samples. The study underscores the significance of antimicrobial stewardship programs and stringent food safety measures in preventing the spread of antibiotic-resistant strains and reducing foodborne illnesses. Further research is needed to explore the mechanisms behind antibiotic resistance and toxin production in S. aureus strains from food samples.
Guidelines for non-profit organisation governance in cyber resilience
Authors: Johnson Margaret Mavins
Published: October 2024

Previous research on corporate governance and cyber security risk management has focused primarily on large for-profit organisations. Although this paper includes a focus on cyber resilience strategies non-profit organisation leaders use, a significant aspect of the research exploration is applicable to the growing need for both for-profit and non-profit businesses to develop cyber resilience guidelines to sustain their organisations’ abilities to detect, withstand and recover from cyberattacks and threats. Despite the growing awareness of the importance of cyber resilience, the problem addressed was that a considerable number of organisation senior executives continue to demonstrate an unpreparedness to address information security cybercrime issues and cyber resilience decisions. As a consequence, a single set of standard cyber security risk management procedures related to non-profit organisation cyber resilience decisions did not exist to justify how nonprofit organisation leaders addressed existing network security procedures, implemented strategies or achieved cyber resilience success. This is and has been arguably the most significant threat non-profit organisation leaders have experienced. The goal of this paper is to provide an understanding of non-profit organisation leaders — board chairman, board of directors, executive directors and other executives — cyber security risk management procedures and strategies for cyber resilience board governance in an urban metropolitan city area in the southeastern US. Emerging cyber resilience network security trends and technologies are identified to include the ways non-profit organisation leaders responded to the COVID-19 pandemic health crisis.
Mısır’da Tarih Yazıcılığı
Authors: Macit Abdulkadir , Erol Halil İbrahim
Published: October 2024

Müslümanlar tarih yazıcılığında İslâm’ın kendine özgün tasavvurunun yanı sıra İslâm’ın kendine özgün tasavvurunun yanı sıra Mısır’ın da içinde yer aldığı Hicaz, Bilâdüşşam, Mağrib, Endülüs, Irak, İran, Sind ve Mâverâünnehir gibi kadim medeniyet havzalarında var olan birikimi çok kısa zamanda tevarüs etmişlerdir. Bu mirası daha sistemli ve metodolojik hale getirmişler, tarih yazıcılığında Siyer ve megâzî, genel ve özel tarihler, şehir ve bölge tarihleri şeklinde çok çeşitli türler oluşturmuşlardır. Bu özgünlük ve tevarüsü ahenkli bir şekilde birleştiren Müslümanların 7.-10. yüzyıllar arasında teşekkül eden tarih yazıcılığı bu dönemde Hulefâ-yi Râşidîn, Emevîler, Abbâsîler ve Tolunoğulları olarak Mısır havzasındaki bölge insanları ve tarih birikimi ile etkileşime girmiş, Müslümanların geliştirdiği metodoloji ve oluşturduğu model ile havzanın tarih yazıcılığı değişmiş ve gelişmiştir. Ancak havzanın kendi asıl tarih tasavvurunun etkisi ve katkısı, Müslümanlarda tarih yazıcılığının gelişimini sürdürdüğü 11.-18. asırlarda gerçekleşmiştir. Bu dönemde havzada Fâtımî, Zengî, Eyyûbî, Memlük ve Osmanlı yönetimleri tarihçiler ile sıkı bir ilişki kurmuştur. Gelişimini tamamlamış ve bir metodoloji geliştirmiş olan tarih yazıcılığı bu süreçte özellikle Memlükler döneminde bir devlet merkezi ve İslâm dünyasındaki tarihçilerin sığındığı liman olması itibarıyla yeni bir hal almıştır. Bu yeni hal Müslümanların Gelişim Dönemi tarih yazıcılığının güçlenmesi anlamına gelmiştir. Ancak 19. ve 20. yüzyıldaki Batı karşısındaki geri çekilme ve modernleşme/batılılaşma süreci Mısır havzasında tarih yazıcılığını bir zihnî daralma, fikrî dönüşüm ve tür olarak çeşitlenmeye maruz bırakmıştır. Bu çalışma Mısır havzasındaki Müslümanların tarih yazıcılığı sürecinin bütününü derinlikli bir şekilde ele almayı hedeflemektedir. Bu süreç Mısır havzasında sayısı onu aşan büyük hanedanlıklar dikkate alınarak dört yüzü aşan tarih kaynağı üzerinden incelenmektedir. Bu çalışmanın temel önemi Mısır havzasında tarih yazıcılığında Müslümanların havzada gelişim gösteren güçlü katkısını ve etkisini bütünlüklü bir şekilde ortaya koyma adımını atmasıdır. Çalışmanın amacı ise Türkiye akademyasında son zamanlarda sürekli gelişim gösteren Mısır tarihi çalışmalarına yönelik ilgiyi daha da güçlendirmesi ve tarih yazıcılığı alanındaki devasa birikime dikkat çekmesidir.
Nicaea at 1700: Roots and Branches in African Christianity
Authors: Editors
Published: October 2024

Call for papers for a themed issue of African Christian Theology (September 2025).
Amevenku, Frederick Mawusi, and Isaac Boaheng. Biblical Exegesis in African Context
Authors: SMITH Anthony
Published: October 2024

A Book Note short review of Biblical Exegesis in African Context by Frederick Mawusi Amevenku and Isaac Boaheng (Vernon Press, 2021).
La Théologie de James H. Cone, un Lieu de Libération pour l’Afrique
Authors: KAPWA ILUNGA Frederick
Published: October 2024

Comme pour la plupart de crise contemporaine, la crise africaine est née d’une société dont les déséquilibres méritent d’être étudiés. Le néocolonialisme, l’oppression, la disette traduit au mieux la structure actuelle de l’Afrique. Dès lors le souci de lutte et de libération économique, social et politique semble inévitable. Ainsi le présent article postule la théologie de la libération de James H. Cone (1938–2018) et son ecclésiologie, comme voie de libération pour l’Africain.
Experiencing Salvation in Africa
Authors: IDIALU Raphael Akhijemen
Published: October 2024

A book review essay of Salvation in African Christianity, edited by Rodney L. Reed and David K. Ngaruiya (Langham Global Library, 2023).
Evaluation of IL 12 Gene Expression and Serum Levels of OxPL / apoB in Patients with Coronary Artery Disease
Authors: Parichehreh-Dizaji Somayeh , Hosseini Seyed Kianoosh , Dayani Sepideh Borhan , Maghsoudi Hossein , Esmaily Farzaneh , Amoli Mahsa M.
Published: October 2024

Background Atherosclerotic lesions are formed as a result of low-density lipoprotein (LDL) accumulation, which is produced by oxidizing enzymes and oxidized phospholipids (OxPL). Phospholipid oxide causes inflammation-inducing activation genes and hyper-inflammation in addition to the initiation of inflammation and expression of Th1 cytokines. Interleukin 12 (IL-12) is one of the most significant stimulants of inflammation and immune responses, among the Th1cytokines. Therefore, it may play a significant role in contributing to atherosclerosis. The quantitative expression of IL-12 mRNA, along with serum OxPL levels, has been analyzed in patients with coronary artery disease (CAD). Methods: Coronary angiography patients, aged 45 to 65 years and referred with chest pain, were examined. The patients were classified into normal coronary arteries (N = 38) and severe three-vessel involvement coronary arteries (N = 41). Molecular testing was performed using real-time PCR. Also, an ELISA test was used to check the OxPl level. Results Expression of IL12 in Individuals with coronary artery disease was increased but was not statistically significant.
Modelado geométrico de estructuras anatómicas para análisis por elementos finitos
Authors: Gómez Miller
Published: October 2024

Con el reciente desarrollo de las técnicas de modelado y adquisición de datos 3D, las mallas de triángulos se han convertido en la representación de superficies más popular debido a su simplicidad, eficiencia y flexibilidad. Sin embargo, los requerimientos asociados con la creación de mallas de triángulos a menudo resultan abrumadores en áreas como el modelado geométrico para análisis por elementos finitos. En un esfuerzo por facilitar el desarrollo rápido y robusto de modelos geométricos para simulaciones por elementos finitos, este libro presenta un framework que integra un conjunto de algoritmos y herramientas eficientes y confiables. Si bien este framework se desarrolla inicialmente en el contexto del modelado de estructuras anatómicas, se puede utilizar en un número amplio de aplicaciones en diferentes áreas científicas y de ingeniería, como el diseño asistido por computador, la simulación física, la computación biomédica, el prototipado rápido y la visualización científica, entre otras. Este libro incluye, además, un marco teórico sobre la generación, suavizado y simplificación de mallas de superficie y dos ejemplos de simulaciones por elementos finitos completamente desarrollados usando el software de código abierto FEBio Studio.
Comparison Of Chest CT Scan Between Smokers And Non Smokers
Authors: Ahmed Hussein , Ali Ahmed , Ibrahim Munib , Askar Haidar , Musa Nadim
Published: October 2024

Purpose: Smoking has a direct effect on the respiratory system. The rate of cigarette smoking among the population has continued to increase steadily. The current study identified and compared the respiratory function of young smokers and non-smokers.Subjects: Participants of both sexes, smokers and non-smokers, aged 16 to 62 years, were recruited. Information was collected in Kirkuk Governorate in Azadi hospitals from January to March 2023.METHODS: Participants were asked to complete a questionnaire related to smoking habits, housing, educational level, chronic diseases and the treatments they receive.Results: The CT scan results showed significant differences between the smokers and non-smokers group. Smokers found an abnormal picture of the lung in many patients.Conclusion: The results of this study show that the effects of smoking are present and actual and can be observed in a CT scan, after which the effects are clear on the smoker. This information can be used to show the harm of smoking and should be used to encourage young people to quit smoking or to avoid smoking cigarettes
Gastroprotective activity of the galactomannan extracted from cassia grandis seeds: an in vivo study
Authors: Barbosa João Marcelo Alves Xavier , Nunes Daniel Medeiros , Sabiá Glenda Alcântara , Soares Anísio Francisco , da Silva Teresinha Gonçalves , de Lima Luiza Rayanna Amorim , Rodrigues Natalie Emanuelle Ribeiro , de Albuquerque Priscilla Barbosa Sales
Published: October 2024

Peptic ulcer is a common disease with a high clinical incidence and frequent recurrences. The well-characterized galactomannan-type polysaccharide, extracted from Cassia grandis seeds, can accelerate the stages of wound healing and improve the remodeling of the extracellular matrix of injured tissues; this way, the gastroprotective potential of the galactomannan was proposed to be evaluated in the treatment of rat peptic ulcers induced by ethanol. Galactomannan was extracted by ethanol precipitation and prepared at 0.1, 1.0, and 10 mg/kg concentrations. Male Wistar rats were randomly divided into groups (n = 5) and orally treated with saline (negative control, NC), galactomannan at 0.1 mg/Kg (G0.1), galactomannan at 1.0 mg/Kg (G1), galactomannan at 10 mg/Kg (G10), and lansoprazole 30 mg/Kg (positive control, CP). Ethanol (1 mL/100 g of body mass) was administered 1 h after the treatments and, after another hour, the animals were euthanized. The stomachs were removed, fixed between Petri dishes, and photographed to calculate the percentage of the injured regions by computerized software. Histological analysis and the quantification of lipid peroxidation and reduced glutathione (GSH) were also performed. G1 and G10 reduced the injured area (P < 0.001) by 40 and 36%, respectively, concerning NC. It was observed the preservation of the gastric mucosa in all of the animals treated with galactomannan, in addition to reduced (P < 0.001) lipid peroxidation and GSH levels higher (P < 0.05) than NC. The galactomannan extracted from C. grandis seeds showed gastroprotective activity at 1.0 and 10 mg/kg by reducing the area of ulceration and oxidative stress.
INNOVATIONS IN HUMAN RESOURCE MANAGEMENT IN THE PUBLIC SECTOR OF UKRAINE
Authors: Shostak Viktor
Published: October 2024

The article examines the characteristics of innovations in human resource management within Ukraine’s public sector. It defines the concept of innovation in human resource management as the introduction of new ideas, methods, technologies, and processes aimed at enhancing the efficiency and effectiveness of managing human resources. The importance of studying this topic is highlighted, particularly in light of the need for the public sector and government bodies to adapt to the demands of wartime and the socio-political crisis, as well as the necessity to develop a strategy for advancing the public sector through the implementation of various international agreements. The main objective of the study is to analyze the specific features of introducing innovations in the human resource management system of Ukraine’s public sector. This includes identifying successful practices for implementing electronic systems, key areas for the digitalization of public administration, and promising research directions. The study demonstrates that several organizational, technological, and social variables influence the interactions between employees, management, and other stakeholders. For instance, technological innovations enable the automation of HR processes (e.g., talent management systems, HR analytics, electronic document management platforms) and the use of online tools for employee training and development (e-learning, webinars). Organizational innovations promote the adoption of new management models. The study highlights several priority areas for further development: strategic communications in public policy, shaping the corporate culture of government agencies, defining their mission, strategic goals, values, and vision; fostering innovative leadership; developing horizontal connections within organizations through innovation; and ensuring principles such as fairness, transparency, openness, and equal access through the digital transformation of public administration.
Avaliação de riscos ambientais e vulnerabilidade na praia do Atalaia, Salinópolis, Pará
Authors: Braga Carla , Martins LINDA , Lobato Nayara , Gomes Suliane
Published: October 2024

Em face a importância da Geografia enquanto ciência para a compreensão da dinâmica da paisagem conforme BERTRAND, considerando uma visão sistêmica entre sociedade e natureza, apresenta-se esta pesquisa em conformidade a Geografia física e redução de riscos de desastres. Neste contexto, mostra-se uma estratégia adaptada para a avaliação dos riscos e das vulnerabilidades da interação sistêmica de uma paisagem e uma população exposta, seja ela nativa ou não, no município de Salinópolis, no Estado do Pará. Dessa forma, partindo dos dados quantitativos angariados pelo projeto de pesquisa “Impactos socioambientais na zona costeira amazônica: estudo de caso em Salinópolis-Pará”, do grupo de pesquisa “Saberes geográficos, diálogos entre ensino, pesquisa e extensão”, financiado pelo Instituto Federal do Pará (IFPA), no Campus Belém, cujo o orientador deste projeto é o docente Dr. Ronaldo Braga, avalia-se o processo de ocupação desordenada deste território litorâneo, mais em especifico, na Praia do Atalaia, associado as inquietações que estimularam a elaboração desta pesquisa sobre as discussões em relação aos riscos socioambientais que perpassaram in loco. Visto isso, nesta pesquisa, propõe-se o mapeamento da Praia do Atalaia, apoiado pelas seguintes prerrogativas a serem analisadas: Vulnerabilidade, sancionada pelos protocolados impactos socioambientais na região; os diferentes tipos de Riscos (Físico / Ergonômico / Biológico / Acidentais / Químico), referenciados por uma metodologia adaptada, utilizando o Mapa de Risco da Comissão Interna de Prevenção de Acidentes – CIPA.
Septal perforation repair using costal chondro-perichondrial graft: a case report
Authors: Ku Inhoe , Jeong Jae-Yong , Kim Taek-Kyun
Published: October 2024

Septal perforation is an anatomical defect of the nasal septum that leads to impaired nasal function, including obstruction and respiratory issues. In this study, a novel surgical approach was introduced to address septal perforations, focusing on the use of costal composite chondro-perichondrial grafts bilaterally in a symmetric manner. This composite graft, composed of costal cartilage and perichondrium, provides mechanical support, aids vascularization, and minimizes perichondrial shrinkage. A case study of a 23-year-old patient with septal perforation resulting from multiple rhinoplasty procedures is presented. The surgical procedure involved the use of a composite graft to close the septal perforation and correct the nasal deformity. The postoperative results demonstrated successful septal perforation closure and relief from nasal discomfort. This study highlights the advantages of this method, particularly its simplicity and straightforward surgical procedures for closing septal perforations of various sizes, and its suitability for rhinoplasty surgeons who are familiar with costal cartilage harvesting.
Comparative evaluation of hyaluronic acid-based dressing versus hydrocolloid dressing in rat dermal wound healing
Authors: Lee Hye Mi , Jang Eun Jung , Choi Ki Hun , Na Young Cheon
Published: October 2024

Background: Wound healing is a complex process influenced by a variety of environmental factors. Dressing materials play a critical role in creating barriers against contaminants, maintaining optimal moisture levels, and absorbing wound exudate. Therefore, selecting materials tailored to wound characteristics is crucial for enhancing outcomes. Hyaluronic acid (HA) is a natural biocompatible polymer that supports healing by regulating inflammation and promoting tissue repair. This study compared HA- and hydrocolloid-based hydrogels in a rat model to optimize wound care strategies.Methods: Full-thickness dermal wounds (diameter, 8 mm) were created on the dorsal skin of 12 Sprague-Dawley rats under sevoflurane anesthesia. The wounds were treated with HA/silver sulfadiazine gel (group A), hydrocolloid gel (group B), or left untreated (control), all covered with a transparent dressing. Biopsy specimens on days 3, 7, and 21 were used to assess histological parameters: inflammatory cell infiltration, fibroblast infiltration, collagen deposition, neovascularization, and epithelial thickness, using a semi-quantitative scoring system. Histological analyses were conducted blindly, and statistical analyses were performed using the Kruskal-Wallis test (p< 0.05).Results: On day 3, group A showed significantly higher inflammatory cell infiltration and collagen deposition than other groups, indicating extracellular matrix formation. By day 7, angiogenesis was highest in group A, followed by group B and controls. By day 21, all wounds had completely healed. Epithelial layer thickness, reflecting inflammation and fibroblast maturity, was significantly higher in group A.Conclusion: This study compared HA-based hydrogel and hydrocolloid-based dressings through histological analyses to elucidate wound healing mechanics. HA-based hydrogel dressings significantly enhanced wound recovery. However, generalizing these outcomes requires future studies to expand the range of effective wound treatment materials. These findings underscore the potential of HA-based dressings to enhance clinical outcomes in wound management, suggesting avenues for improving therapeutic strategies.
Intraoperative navigation in craniofacial surgery
Authors: Kang Dong Hee
Published: October 2024

Craniofacial surgery requires comprehensive anatomical knowledge of the head and neck to ensure patient safety and surgical precision. Over recent decades, there have been significant advancements in imaging techniques and the development of real-time surgical navigation systems. Intraoperative navigation technology aligns surgical instruments with imaging-derived information on patient anatomy, enabling surgeons to closely follow preoperative plans. This system functions as a radiologic map, improving the accuracy of instrument placement and minimizing surgical complications. The introduction of first-generation navigation systems in the early 1990s revolutionized surgical procedures by enabling real-time tracking of instruments using preoperative imaging. Initially utilized in neurosurgery, intraoperative navigation has since become standard practice in otolaryngology, cranio-maxillofacial surgery, and orthopedics. Since the 2000s, second-generation navigation systems have been developed to meet the growing demand for precision across various surgical specialties. The adoption of these systems in craniofacial surgery has been slower, but their use is increasing, particularly in procedures such as foreign body removal, facial bone fracture reconstruction, tumor resection, and craniofacial reconstruction and implantation. In Korea, insurance coverage for navigation in craniofacial surgery began in 2021, and new medical technologies for orbital wall fracture treatment were approved in August 2022. These technologies have only recently become clinically available, but are expected to play an increasingly important role in craniofacial surgery. Intraoperative navigation enhances operative insight, improves target localization, and increases surgical safety. Although these systems have a steep learning curve and initially prolong surgery, efficiency improves with experience. Calibration issues, registration errors, and soft tissue deformation can introduce inaccuracies. Nonetheless, navigation technology is evolving, and the integration of intraoperative computed tomography data holds promise for further enhancements of surgical accuracy. This paper discusses the various types and applications of navigation employed in craniofacial surgery, highlighting their benefits and limitations.
The natural history of cerebral infundibula: A retrospective cohort study
Authors: Yousif Saif , Vile Alexander , Barot Dwarkesh Dharmendra , Cho Charlie , Pattavilakom Ananthababu Sadasivan , Jayalath Rumal
Published: October 2024

Objective: Debate exists regarding the true pathogenicity of cerebral infundibula (CI). Pre-aneurysmal lesions and benign anatomical variants have both been proposed. In this study, we present the largest single cohort series on the natural history of CI.Methods: Retrospective review of prospective surveillance of 420 CI was undertaken in a single tertiary cerebrovascular centre. All CI diagnosed by a neuroradiologist, diagnosed on either a Magnetic resonance angiography (MRA), Computed tomography angiography (CTA) or Digital subtraction angiography (DSA) were eligible for inclusion. Imaging and demographic characteristics were recorded at baseline. CI growth and aneurysm transformation were the outcomes of interest. Groupwise comparison was conducted via Fischer exact testing. Kaplan Meir curves and Cox proportional hazard ratios were used to assess variables of interest with respect to time on surveillance.Results: 402 patients with 420 CI were surveyed over 2418 infundibula-years. Eleven CI (2.62%) grew on surveillance, and three (0.7%) transformed into aneurysms. Median time to growth was 85 months (36-263) and median time to aneurysm transformation was 112 months (96-142). Of the CI that grew, male sex and CI >2 mm at diagnosis were significant predictors of growth (all p<0.05). Of the CI that grew in surveillance, 2/11 (18.2%) transformed into aneurysms (p=0.001). Aneurysm transformation occurred at a rate of 1.27 per 1000 infundibula years. CI growth on surveillance (p= 0.00016) and size at diagnosis (p=0.038) remained significant predictors of aneurysm transformation on Kaplan Meir curves.Conclusions: The transformation of a CI to an aneurysm occurs at a low rate. A history of growth on surveillance imaging represents significant risk for aneurysm transformation.
Dilution refrigeration technology
Authors: Zheng Mao-Wen , Guo Hao-Wen , Wei Ling-Jiao , Pan Zi-Jie , Zou Jia-Run , Li Rui-Xin , Zhao Mi-Guang , Chen Hou-Lei , Liang Jing-Tao ,   Key Laboratory of Technology on Space Energy Conversion, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China,   Key Laboratory of Cryogenic Science and Technology, Beijing 100190, China,   University of Chinese Academy of Sciences, Beijing 100049, China
Published: October 2024

Dilution refrigerator, as a refrigeration technology that can obtain extremely low temperatures below 10 mK, is widely used in fields such as quantum computing, and condensed matter physics. The development of the most widely used typical dry dilution refrigerators has been relatively mature, while there is little research on other types of dilution refrigerators, and there is a lack of comprehensive and systematic research on dilution refrigeration technology.

This paper focuses on the current status of dilution refrigeration technology research, introduces its basic principles, and points out that the fundamental reason for continuous refrigeration is the limited solubility of 3He in 4He and the difference in enthalpy between the concentrated phase and the dilute phase. This paper summarizes the realization forms and research progress of typical dilution refrigerators, 4He cycle dilution refrigerators, cold cycle dilution refrigerators, and space dilution refrigerators, and discusses their respective application occasions and advantages and disadvantages. From the Kapitza thermal resistance, osmotic pressure, and resistance, this paper analyzes the key influencing factors and design calculation methods for realizing dilution refrigerators below 10 mK, which provides reference for studying dilution refrigeration technology.
Detection of changes in membrane potential by magnetic resonance imaging
Authors: Min Kyeongseon , Chung Sungkwon , Lee Seung-Kyun , Lee Jongho , Toi Phan Tan , Kim Daehong , Lee Jung Seung , Park Jang-Yeon
Published: October 2024

Membrane potential plays a crucial role in various cellular functions. However, existing techniques for measuring membrane potential are often invasive or have limited recording depth. In contrast, magnetic resonance imaging (MRI) offers noninvasive imaging with desirable spatial resolution over large areas. This study investigates the feasibility of utilizing MRI to detect membrane potential changes by measuring magnetic resonance parameters while manipulating membrane potential in cultured cells and
in vivo
rat models. Our findings reveal that depolarization (or hyperpolarization) of the membrane potential increases (or decreases) the
T
2
relaxation time, while the ratio of bound to free water proton shows the opposite trend. These findings also suggest a pioneering approach to noninvasively detect changes in membrane potential using MRI.
Regional response to light illuminance across the human hypothalamus
Authors: Campbell Islay , Sharifpour Roya , Balda Aizpurua Jose Fermin , Beckers Elise , Paparella Ilenia , Berger Alexandre , Koshmanova Ekaterina , Mortazavi Nasrin , Read John , Zubkov Mikhail , Talwar Puneet , Collette Fabienne , Sherif Siya , Phillips Christophe , Lamalle Laurent , Vandewalle Gilles
Published: October 2024

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, the subcortical circuitry underlying the stimulating impact of light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess the impact of variations in light illuminance on the regional activity of the hypothalamus while healthy young adults (N=26; 16 women; 24.3±2.9 y) were completing two auditory cognitive tasks. We find that, during both the executive and emotional tasks, higher illuminance triggered an activity increase over the posterior part of the hypothalamus, which includes part of the tuberomamillary nucleus and the posterior part of the lateral hypothalamus. In contrast, increasing illuminance evoked a decrease in activity over the anterior and ventral parts of the hypothalamus, encompassing notably the suprachiasmatic nucleus and another part of the tuberomammillary nucleus. Critically, the performance of the executive task was improved under higher illuminance and was negatively correlated with the activity of the posterior hypothalamus area. These findings reveal the distinct local dynamics of different hypothalamus regions that underlie the impact of light on cognition.
A synthetic method to assay polycystin channel biophysics
Authors: Larmore Megan , Esarte Palomero Orhi , Kamat Neha , DeCaen Paul G
Published: October 2024

Ion channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted in human diseases. Organelle ion channels are among the most resistant to functional and pharmacological interrogation. Traditional channel protein reconstitution methods rely upon exogenous expression and/or purification from endogenous cellular sources which are frequently contaminated by resident ionophores. Here, we describe a fully synthetic method to assay functional properties of polycystin channels that natively traffic to primary cilia and endoplasmic reticulum organelles. Using this method, we characterize their oligomeric assembly, membrane integration, orientation, and conductance while comparing these results to their endogenous channel properties. Outcomes define a novel synthetic approach that can be applied broadly to investigate channels resistant to biophysical analysis and pharmacological characterization.
An interpretable deep learning model for detecting BRCA pathogenic variants of breast cancer from hematoxylin and eosin-stained pathological images
Authors: Li Yi , Xiong Xiaomin , Liu Xiaohua , Wu Yihan , Li Xiaoju , Liu Bo , Lin Bo , Li Yu , Xu Bo
Published: October 2024

Background

Determining the status of breast cancer susceptibility genes (BRCA) is crucial for guiding breast cancer treatment. Nevertheless, the need for BRCA genetic testing among breast cancer patients remains unmet due to high costs and limited resources. This study aimed to develop a Bi-directional Self-Attention Multiple Instance Learning (BiAMIL) algorithm to detect BRCA status from hematoxylin and eosin (H&E) pathological images.

Methods

A total of 319 histopathological slides from 254 breast cancer patients were included, comprising two dependent cohorts. Following image pre-processing, 633,484 tumor tiles from the training dataset were employed to train the self-developed deep-learning model. The performance of the network was evaluated in the internal and external test sets.

Results

BiAMIL achieved AUC values of 0.819 (95% CI [0.673–0.965]) in the internal test set, and 0.817 (95% CI [0.712–0.923]) in the external test set. To explore the relationship between BRCA status and interpretable morphological features in pathological images, we utilized Class Activation Mapping (CAM) technique and cluster analysis to investigate the connections between BRCA gene mutation status and tissue and cell features. Significantly, we observed that tumor-infiltrating lymphocytes and the morphological characteristics of tumor cells appeared to be potential features associated with BRCA status.

Conclusions

An interpretable deep neural network model based on the attention mechanism was developed to predict the BRCA status in breast cancer. Keywords: Breast cancer, BRCA, deep learning, self-attention, interpretability.