bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Palladium‐Catalyzed Stereospecific Decarboxylative Benzylation of Alkynes.
Authors: Mendis Shehani N. , Tunge Jon A.
Published: March 2016

The highly stereospecific decarboxylative coupling of benzylic esters of propiolic acids to 1,1′‐diarylethinyl methanes is described.
ChemInform Abstract: Photoinduced C—S Bond Cleavage of Thioglycosides and Glycosylation.
Authors: Mao Run‐Ze , Guo Fan , Xiong De‐Cai , Li Qin , Duan Jinyou , Ye Xin‐Shan
Published: March 2016

Activation of thioglycosides upon UV irradiation followed by cupric triflate oxidation leads to the in situ formation of an oxacarbenium ion which is able to undergo glycosylation reactions with a wide variety of substrates such as sugars, amino acids, terpenes, and sterols.
ChemInform Abstract: Asymmetric Aldol—Tishchenko Reaction of Sulfinimines.
Authors: Foley Vera M. , McSweeney Christina M. , Eccles Kevin S. , Lawrence Simon E. , McGlacken Gerard P.
Published: March 2016

The first example of an aldol—Tishchenko reduction of imines is reported.
ChemInform Abstract: Development of a Direct Photocatalytic C—H Fluorination for the Preparative Synthesis of Odanacatib.
Authors: Halperin Shira D. , Kwon Daniel , Holmes Michael , Regalado Erik L. , Campeau Louis‐Charles , DiRocco Daniel A. , Britton Robert
Published: March 2016

A one‐step photocatalytic fluorination of (S)‐leucine methyl ester (I) is thoroughly elaborated which allows for the multi‐gram preparation of (S)‐γ‐fluoroleucine methyl ester (II) under continuous flow conditions, thus representing a straightforward access to the critical intermediate (II) of odanacatib (III).
ChemInform Abstract: Metal Free Synthesis of α‐Keto Amides from 2‐Hydroxy Acetophenones Through Domino Alcohol Oxidation—Oxidative Amidation Reaction.
Authors: Kotha Surya Srinivas , Sekar Govindasamy
Published: March 2016

An economic and environment friendly IBX promoted synthesis of α‐keto amides from α‐oxoalcohols and amines through domino alcohol oxidation—oxidative amidation reaction sequence under metal‐free conditions is reported.
ChemInform Abstract: Iron‐Catalyzed Alkoxycarbonylation—Peroxidation of Alkenes with Carbazates and T‐Hydro.
Authors: Zong Zhenzhen , Lu Shenglin , Wang Wenxiao , Li Zhiping
Published: March 2016

The three‐component reaction allows the synthesis of β‐ester peroxides with high regioselectivity in a single step.
ChemInform Abstract: [(tert‐Butyldimethylsilyl)oxy]methanethiol (II) and [(tert‐Butyldiphenylsilyl)oxy]methanethiol (IV) — Nucleophilic Protected H2S Equivalents.
Authors: Dong Shuai , Clive Derrick L.J. , Gao Jin‐Ming
Published: March 2016

The title silyloxymethanethiols (II) and (IV) act as nucleophilic reagents for the introduction of a protected bivalent sulfur.
ChemInform Abstract: Amidation of Norbornene with Organic Nitriles in the Presence of Water Catalyzed by Iron Compounds.
Authors: Khusnutdinov Ravil I. , Oshnyakova Tatyana M.
Published: March 2016

A new catalytic method for the amidation of norbornene using organic nitriles in the presence of water and FeCl3·6H2O is developed.
ChemInform Abstract: Organocatalytic Asymmetric Desymmetrization of 4,4‐Disubstituted Cyclohexadienones via an Intermolecular Diels—Alder Reaction.
Authors: Takagi Ryukichi , Nishi Takehiko
Published: March 2016

Masked dienones bearing an all‐carbon quaternary stereogenic center are obtained with good enantioselectivities.
ChemInform Abstract: Synthesis and Conjugate Addition Reactions of N‐(β‐Nitroalkyl)amides.
Authors: Wade Peter A. , Paparoidamis Nicholas , Liao Jennie , Manor Brian C. , DeBolt Kristine
Published: March 2016

Nitration of alkenes (II) and (VII) with LiNO3/TFAA in nitrile solvents provides N‐(β‐nitroalkyl)amides, which undergo Michael addition to acceptors (V).
ChemInform Abstract: Ligand‐ and Acid‐Free Gold(I) Chloride Catalyzed Hydration of Terminal Alkynes.
Authors: Das Atanu Kumar , Park Sangseung , Muthaiah Senthilkumar , Hong Soon Hyeok
Published: March 2016

The hydration in presence of AuCl/MeOH affords the methyl ketones without any additive, ligand or acid promoter under mild conditions.
ChemInform Abstract: Anionic Phenoxy‐Amido Rare‐Earth Complexes as Efficient Catalysts for Amidation of Aldehydes with Amines.
Authors: Wang Chao , Huang Lingling , Lu Min , Zhao Bei , Wang Yaorong , Zhang Yong , Shen Qi , Yao Yingming
Published: March 2016

Ten novel anionic phenoxy‐amido rare‐earth complexes stabilized by dianionic phenoxy‐amido ligands are synthesized and utilized as efficient catalysts for the amidation reactions of aldehydes with amines affording the corresponding amides under mild reaction conditions.
ChemInform Abstract: A Nonoxidative Passerini Pathway to α‐Ketoamides.
Authors: Abdessalem Abdelbari Ben , Abderrahim Raoudha , El Kaim Laurent
Published: March 2016

The two‐step sequence affords α‐ketoamides using a multicomponent reaction.
ChemInform Abstract: Oxidative Fluorination of N‐Arylsulfonamides.
Authors: Buckingham Faye , Calderwood Samuel , Checa Begona , Keller Thomas , Tredwell Matthew , Collier Thomas Lee , Newington Ian M. , Bhalla Rajiv , Glaser Matthias , Gouverneur Veronique
Published: March 2016

N‐arylsulfonamides para substituted with a tert‐butyl group on the aniline are regioselectively fluorinated by ipso substitution of the tert‐butyl group.
ChemInform Abstract: Direct S‐Difluoromethylation of Thiols Using the Ruppert—Prakash Reagent.
Authors: Prakash G. K. Surya , Krishnamoorthy Sankarganesh , Kar Sayan , Olah George A.
Published: March 2016

Aromatic and aliphatic difluoromethyl sulfides are selectively obtained with good functional group tolerance from inexpensive and commercially available starting materials.
ChemInform Abstract: Visible‐Light‐Induced Direct α‐C(sp3)—H Thiocyanation of Tertiary Amines.
Authors: Yadav Arvind K. , Yadav Lal Dhar S.
Published: March 2016

The reaction proceeds under mild conditions via visible‐light‐induced in situ formation of the iminium ion followed by attack of the rhodanid nucleophile to form the corresponding products in good to excellent yields.
ChemInform Abstract: Room‐Temperature Suzuki—Miyaura Cross‐Coupling Reaction with α‐Diimine Pd(II) Catalysts.
Authors: Wang Fuzhou , Tanaka Ryo , Cai Zhengguo , Nakayama Yuushou , Shiono Takeshi
Published: March 2016

A set of efficient α‐diimine Pd(II) complexes are synthesized to catalyze the Suzuki—Miyaura cross‐coupling reaction of anilines and phenylboronic acids.
ChemInform Abstract: Transition‐Metal‐Free Multicomponent Benzannulation Reactions for the Construction of Polysubstituted Benzene Derivatives.
Authors: Shu Wen‐Ming , Zheng Kai‐Lu , Ma Jun‐Rui , Wu An‐Xin
Published: March 2016

The efficient title reaction of ethoxycarbonyl, benzoyl or cyano substituted aryl or alkylketones with trans‐β‐nitrostyrenes and acetylene dicarboxylates provides polysubstituted phthalic acid derivatives in high yields.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular Aryldifluoroalkylation of Alkynes.
Authors: He Yu‐Tao , Wang Qiang , Li Lian‐Hua , Liu Xue‐Yuan , Xu Peng‐Fei , Liang Yong‐Min
Published: March 2016

The scalable reaction between aryl‐ or alkyl‐alkynes, arylboronic acids and ethyl difluoroiodoacetate tolerates various functional groups and delivers the products in high yields.
ChemInform Abstract: Organocopper‐Triggered Cyclization of Conjugated Diene‐ynes: Diastereo‐ and Enantioselective Synthesis of Indenes.
Authors: Arif Tanzeel , Borie Cyril , Tintaru Aura , Naubron Jean‐Valere , Vanthuyne Nicolas , Bertrand Michele P. , Nechab Malek
Published: March 2016

A new method for the construction of chiral indenes bearing two stereogenic centers is developed.
ChemInform Abstract: C60(C6H4Me)4Ph4: A Fully Substituted Derivative of the Pentagon‐Fused C60Cl8.
Authors: Liang Hua , Dai Ke , Guo Zhi C. , Peng Ru F.
Published: March 2016

The eight chlorines of C60Cl8 with two pairs of fused pentagons are successfully substituted by sterically encumbering groups through the Friedel—Crafts reaction to get the title compound, which provides a facile way for multiple modification of special fullerenes.
ChemInform Abstract: Enantioselective Construction of Spiroindolines with Three Contiguous Stereogenic Centers and Chiral Tryptamine Derivatives via Reactive Spiroindolenine Intermediates.
Authors: Zhuo Chun‐Xiang , Zhou Yong , Cheng Qiang , Huang Lin , You Shu‐Li
Published: March 2016

Enantioenriched spiroindoles are highly efficiently obtained by iridium‐catalyzed asymmetric allylic dearomatization and reduction.
ChemInform Abstract: Reaction of Arylmethylidene Derivatives of 3H‐Furan‐2‐ones with Azomethine Ylide.
Authors: Anis'kov Alexander A. , Kamneva Irine Ye. , Zheleznova Maria A. , Yegorova Alevtina Yu.
Published: March 2016

The title 1,3‐dipolar cycloaddition procedure leads diastereoselectively to the previously unknown dispiropyrrolidine derivatives (IV) via an endo‐transition state.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Oxidative Coupling of Alkenes/α‐Bromoacetophenones with Aldehydes: A Facile Entry to α,β‐Epoxy Ketones.
Authors: Reddi Rambabu N. , Prasad Pragati K. , Sudalai Arumugam
Published: March 2016

NBS/DBU/DMSO is used as oxidative system for the regioselective oxidative coupling reactions.
ChemInform Abstract: Synthesis of Diversely Substituted 2‐(Furan‐3‐yl)acetates from Allenols Through Cascade Carbonylations.
Authors: He Yan , Zhang Xinying , Fan Xuesen
Published: March 2016

A novel strategy to diversely substituted 2‐(furan‐3‐yl)acetates via a one‐pot cascade reaction of allenoles with aryl iodides, alcohols, and carbon monoxides is presented.
ChemInform Abstract: Non‐decarbonylative Photochemical versus Thermal Activation of Bu4N[Fe(CO)3(NO)] — The Fe‐Catalyzed Cloke—Wilson Rearrangement of Vinyl and Arylcyclopropanes.
Authors: Lin Che‐Hung , Pursley Dominik , Klein Johannes E. M. N. , Teske Johannes , Allen Jennifer A. , Rami Fabian , Koehn Andreas , Plietker Bernd
Published: March 2016

The Fe‐catalyzed Cloke—Wilson rearrangement of vinylcyclopropanes (I), (IV), and (VI) under photochemical conditions proceeds in a shorter time and with similar or higher yields compared to the reaction under thermal conditions.
ChemInform Abstract: Enantioselective Synthesis of α‐exo‐Methylene γ‐Butyrolactones via Chromium Catalysis.
Authors: Chen Weiqiang , Yang Qin , Zhou Tian , Tian Qingshan , Zhang Guozhu
Published: March 2016

Following a two‐step reaction sequence consisting of an asymmetric carbonyl 2‐(alkoxycarbonyl)allylation and lactonization, a variety of functionalized alkyl and aryl substituted products are prepared in high yields and with very high enantiomeric excesses.
ChemInform Abstract: Squaramide‐Catalyzed Asymmetric Cascade Aza‐Michael/Michael Addition Reaction for the Synthesis of Chiral Trisubstituted Pyrrolidines.
Authors: Zhao Bo‐Liang , Lin Ye , Yan Hao‐Hao , Du Da‐Ming
Published: March 2016

The title reaction provides easy access to highly functionalized chiral pyrrolidines with a broad substrate scope, giving the desired products with high diastereoselectivities and excellent enantioselectivities under mild conditions.
ChemInform Abstract: Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations.
Authors: Li Xiaoxun , Li Hui , Song Wangze , Tseng Po‐Sen , Liu Lingyan , Guzei Ilia A. , Tang Weiping
Published: March 2016

Propargylic alcohol substrates bearing an aryl ring with ortho N‐SO2‐aryl groups are treated with 2 equiv.
ChemInform Abstract: Sequential Substitution/Ring Cleavage/Addition Reaction of 1‐(Cyclohex‐1‐enyl)‐piperidine and ‐pyrrolidine with Chloropyruvates for the Efficient Synthesis of Substituted 4,5,6,7‐Tetrahydro‐1H‐indole Derivatives.
Authors: Mamedov Vakhid A. , Hafizova Elena A. , Zamaletdinova Anastasiya I. , Rizvanov Il'dar Kh. , Mirgorodskaya Alla B. , Zakharova Lucia Ya. , Latypov Shamil K. , Sinyashin Oleg G.
Published: March 2016

The preparation of the required enamine in‐situ from cyclohexenone and pyrrolidine is shown, thus leading to an efficient sequential three‐component heteroannulation reaction.
ChemInform Abstract: Manganese(I)‐Catalyzed C—H Aminocarbonylation of Heteroarenes.
Authors: Liu Weiping , Bang Jonas , Zhang Yujiao , Ackermann Lutz
Published: March 2016

A versatile manganese(I) catalyst is employed in C—H aminocarbonylation reactions of heteroarenes with aryl as well as with alkyl isocyanates using a removable directing group approach.
ChemInform Abstract: Ni(II)‐Catalyzed Highly Stereo‐ and Regioselective Syntheses of Isoindolinones and Isoquinolinones from in situ Prepared Aldimines Triggered by Homoallylation/Lactamization Cascade.
Authors: Karmakar Raju , Suneja Arun , Bisai Vishnumaya , Singh Vinod K.
Published: March 2016

Excellent selectivity for terminal attack of the diene component is observed except for reactions involving o‐substituted aniline components like (IX).
ChemInform Abstract: Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction.
Authors: de Graaff Corien , Bensch Lisa , Boersma Sjoerd J. , Cioc Razvan C. , van Lint Matthijs J. , Janssen Elwin , Turner Nicholas J. , Orru Romano V. A. , Ruijter Eelco
Published: March 2016

The interrupted Fischer indole synthesis of arylhydrazines and biocatalytically generated chiral bicyclic imines selectively affords either tetracyclic pyrroloindolines or tricyclic tryptamine analogues depending on the reaction conditions.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Δ2‐Isoxazoline from Toluene Derivatives Enabled by the Triple Role of Silver Nitrate.
Authors: Li Chengliang , Deng Hongmei , Li Chunju , Jia Xueshun , Li Jian
Published: March 2016

Silver nitrate plays an unusual triple role as oxidant for the generation of Pd(II), the nitrogen source, and the dehydration reagent.
ChemInform Abstract: Synthesis of 5‐(Polyfluoroalkyl)‐1,3‐thiazolidines from Polyfluoroalkanethiocarboxylic Acid Derivatives.
Authors: Mykhaylychenko Sergiy S. , Siryi Serhii A. , Pikun Nadezhda V. , Shermolovich Yuriy G.
Published: March 2016

The title compounds are prepared by the reaction of perfluorothiocarboxylates with azomethine ylide generated in situ via acid‐catalyzed desilylation of (II).
ChemInform Abstract: Novel Method for the Synthesis of Substituted Imidazothiazolones.
Authors: Kravchenko Angelina N. , Antonova Maria M. , Baranov Vladimir V. , Nelyubina Yulia V.
Published: March 2016

A novel, highly selective method is presented for the preparation of the title compounds using thiocyanate in the presence of acetic acid.
ChemInform Abstract: Oximinoalkylamines as Ligands for Cu‐Assisted Azide—Acetylene Cycloaddition.
Authors: Semakin Artem N. , Agababyan Daniil P. , Kim Sohee , Lee Sangyoon , Sukhorukov Alexey Yu. , Fedina Ksenia G. , Oh Jinho , Ioffe Sema L.
Published: March 2016

The oxime group may be considered as an efficient binding motif for the design of ligands to accelerate the Cu‐assisted azide—acetylene cycloaddition reaction.
ChemInform Abstract: Hypervalent Iodine‐Mediated Intramolecular trans‐Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal‐Free Conditions.
Authors: Zhang Xiang , Hou Wenjuan , Zhang‐Negrerie Daisy , Zhao Kang , Du Yunfei
Published: March 2016

The trans‐aminocarboxylation of alkynes is performed following a two‐pot two‐step reaction procedure while delivering fused polyheterocyclic compounds in high yields.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Alkene C—H Bond Functionalization on Cinnamic Acids: A Facile Synthesis of Versatile α‐Pyrones.
Authors: Prakash Rashmi , Shekarrao Kommuri , Gogoi Sanjib
Published: March 2016

The title reactions features the broad substrate scope, high regioselectivity with some unsymmetrical alkynes, and high yields.
ChemInform Abstract: Enantioselective Copper(I)‐Catalyzed Alkynylation of Oxocarbenium Ions to Set Diaryl Tetrasubstituted Stereocenters.
Authors: Dasgupta Srimoyee , Rivas Thomas , Watson Mary P.
Published: March 2016

Readily available, racemic ketals are efficiently converted into highly enantioenriched isochroman products with fully substituted stereogenic centers.
ChemInform Abstract: Synthesis, Characterization, and Antibacterial Evaluation of New Alkyl 2‐Amino‐4‐aryl‐4H‐chromene‐3‐carboxylates.
Authors: Gholipour Sedighe , Davoodnia Abolghasem , Nakhaei‐Moghaddam Mahboobeh
Published: March 2016

The title compounds are prepared by cyclocondensation of resorcinol, benzaldehydes, and cyanoacetates.
ChemInform Abstract: Regioselective Suzuki—Miyaura Reactions of the Bis(triflate) of 4′,7‐Dihydroxyisoflavone.
Authors: Hamdy Aws M. , Khaddour Zien , Villinger Alexander , Langer Peter
Published: March 2016

The regioselective reaction of the bis(triflates) with arylboronic acid affords diarylisoflavones in good yields favoring the electronically more deficient C‐7 position for the first attack.
ChemInform Abstract: Zn2+/MCM‐41 Catalyzed Biginelli Reaction of Heteroaryl Aldehydes and Evaluation of the Antimicrobial Activity and Cytotoxicity of the Pyrimidone Products.
Authors: Ghasemi Zarrin , Farshbaf Orafa Farzaneh , Pirouzmand Mahtab , Zarrini Gholamreza , Nikzad Kojanag Behnaz , Salehi Roya
Published: March 2016

Aldehydes (I) and (V) undergo a three component Biginelli condensation with 1,3‐dicarbonyls and urea in the presence of catalytic amounts of ZnNO3 or ZnNO3 supported on MCM‐41.
ChemInform Abstract: A General Synthesis of Novel Quinoline‐Based Isoindolin‐1‐one Derivatives.
Authors: Li Yang , Zhang Hong
Published: March 2016

The new method leading to novel quinoline‐based isoindolin‐1‐one derivatives involves a cascade Williamson‐type condensation reaction of quinoline‐3‐carboxylate with aromatic, aliphatic amines, or aliphatic diamines (IV) and subsequent intramolecular C‐N bond cyclization in one‐pot.
ChemInform Abstract: Auto‐Tandem Palladium Catalysis: From Isoxazole to 2‐Azafluorenone.
Authors: Das Sajal , Hong Dongsub , Chen Zhiwei , She Zhigang , Hersh William H. , Subramaniam Gopal , Chen Yu
Published: March 2016

The reactions proceed via a Heck reaction followed by a Pd‐catalyzed rearrangement.
ChemInform Abstract: Enaminone‐Based Three‐Component Reactions for the Diastereoselective Synthesis of Fused Tetrahydropyridines.
Authors: Wan Jie‐Ping , Zhong Shanshan , Liu Yunyun
Published: March 2016

An environmentally benign method is developed for the preparation of dihydropyridobenzoxazoles from enaminones, aminophenols, and cinnamaldehydes.
ChemInform Abstract: Catalyst‐Free, One Pot and Three‐Component Synthesis of 4′‐Phenyl‐1′H‐spiro[indoline‐3,2′‐quinazolin]‐2‐ones and 2,4‐Diphenyl‐1,2‐dihydroquinazolines.
Authors: Kamal Ahmed , Babu Korrapati Suresh , Chandrasekhar Cheemalamarri , Nagaraju Burri , Visweswara Sastry K. N. , Ganesh Kumar C.
Published: March 2016

A simple, mild, efficient and environmentally benign method for the synthesis of the title compounds is developed without using any catalyst in ethanol.
ChemInform Abstract: Ir‐Catalyzed C—H Silylations of Phenyldeazapurines.
Authors: Sabat Nazarii , Postova Slavetinska Lenka , Hocek Michal
Published: March 2016

The silylation of phenyldeazapurines (I) and (IV) with trialkylsilanes (II) proceeds preferentially at the ortho‐position of the phenyl ring due to the directing effect of the N1 atom.
ChemInform Abstract: Efficient Access to 2,3‐Dihydroquinazolin‐4(1H)‐ones by Environmentally Benign L‐Proline Nitrate as Recyclable Catalyst.
Authors: Bahekar Sandeep P. , Dahake Nityanand D. , Sarode Prashant B. , Chandak Hemant S.
Published: March 2016

L‐Proline nitrate is used as a green catalyst for a one‐pot cyclocondensation of anthranilamide and aldehydes under mild conditions.
ChemInform Abstract: Intramolecular Conversion of N,N‐Bis(2‐picolyl)ureas to Cyclic Carbamates.
Authors: Jakob Uwe , Bannwarth Willi
Published: March 2016

A new approach for synthesizing cyclic urethanes from N,N‐bis(2‐picolyl)urea‐derivatives is reported.
ChemInform Abstract: Sulfonamide and Tertiary Amine as Nucleophiles in Pd(II)‐Catalyzed Diamination of Alkynes: Synthesis of Tetracyclic Indolobenzothiazine S,S‐Dioxides.
Authors: Ha Tu M. , Yao Bo , Wang Qian , Zhu Jieping
Published: March 2016

A high‐yielding three‐step preparation of the title products is described consisting of a Sonogashira‐coupling of 2‐iodobenzenesulfonamides with N‐2‐(methoxycarbonyl)ethyl protected 2‐alkynylaniline, Pd‐catalyzed intramolecular diamination, and removal of the N‐protecting group.
ChemInform Abstract: Benzoic Acid Catalyzed Annulations of α‐Amino Acids and Aromatic Aldehydes Containing an ortho‐Michael Acceptor: Access to 2,5‐Dihydro‐1H‐benzo[c]azepines and 10,11‐Dihydro‐5H‐benzo[e]pyrrolo[1,2‐a]azepines.
Authors: Tang Mi , Tong Lingfeng , Ju Lei , Zhai Wanwan , Hu Yang , Yu Xinhong
Published: March 2016

A broad range of the title substrates reacts with proline, sarcosine or L‐thioproline following a rapid microwave‐assisted approach to provide 2,5‐dihydro‐1H‐benzo[c]azepines in high yields.
ChemInform Abstract: Condensation‐Driven Assembly of Boron‐Containing Bis(Heteroaryl) Motifs Using a Linchpin Approach.
Authors: Adachi Shinya , Liew Sean K. , Lee C. Frank , Lough Alan , He Zhi , Denis Jeffrey D. St. , Poda Gennady , Yudin Andrei K.
Published: March 2016

A strategy for the synthesis of novel boron‐containing bis(heteroaryl) systems is outlined.
ChemInform Abstract: Fe3O4@MgO Nanoparticles as an Efficient Recyclable Catalyst for the Synthesis of Phosphoroamidates via the Atherton—Todd Reaction.
Authors: Kaboudin Babak , Kazemi Foad , Habibi Fereshteh
Published: March 2016

A simple, and convenient method for the synthesis of phosphoroamidates via the Atherton—Todd coupling reaction of amines with dialkyl phosphites is reported.
ChemInform Abstract: Metal‐Free Synthesis of Chlorinated and Brominated Phosphinoyl 1,3‐Butadiene Derivatives and Its Synthetic Applications.
Authors: Liu Teng , Xia Yun‐Tao , Zhu Jie , Lu Ai‐Min , Wu Lei
Published: March 2016

The HCl/HBr solutions enable the in situ rearrangement of phosphinoyl‐α‐allenic alcohols to conjugated vinyl cations, which afford various polysubstituted phosphinoyl 1,3‐butadienes.
ChemInform Abstract: Synthesis of New 2‐[2‐(Dialkyl(diaryl)‐phosphoryl)‐2‐methylpropyl]quinoline‐4‐carboxylic Acids
Authors: Tatarinov Dmitry A. , Osipova Viktoria I. , Bogdanov Andrei V. , Krivolapov Dmitry B. , Voloshina Alexandra D. , Mironov Vladimir F.
Published: March 2016

by Pfitzinger reaction of isatin with phosphine oxides (II)
ChemInform Abstract: Catalytic Asymmetric endo‐Selective [3 + 2] Cycloaddition Reactions of Schiff Bases of α‐Aminophosphonates with Olefins Using Chiral Metal Amides.
Authors: Yamashita Yasuhiro , Nam Liang Cheng , Dutton Mark J. , Yoshimoto Susumu , Kobayashi Shu
Published: March 2016

Besides the Cu‐catalyst a corresponding Ag‐catalyst can be used as well.
ChemInform Abstract: Amotsaokonal A—C, Benzaldehyde and Cycloterpenal from Amomum tsao‐ko.
Authors: Hong Seong Su , Lee Ji Hye , Choi Yun‐Hyeok , Jeong Wonsik , Ahn Eun‐Kyung , Lym Seung Ho , Oh Joa Sub
Published: March 2016

The novel benzaldehyde amotsaokonal A (I) and two new cycloterpenals amotsaokonal B (II) and (III) C along with five known compounds are isolated from the fruits of Amonum tsao‐ko.
ChemInform Abstract: Wittig Reaction: Domino Olefination and Stereoselectivity DFT Study. Synthesis of the Miharamycins′ Bicyclic Sugar Moiety.
Authors: Rauter Amelia P. , et al.
Published: March 2016

The Wittig reaction of different uloses is studied.
ChemInform Abstract: Edonamides, the First Secondary Metabolites from the Recently Described Myxobacterium Aggregicoccus edonensis.
Authors: Karwehl Sabrina , Mohr Kathrin I. , Jansen Rolf , Sood Sakshi , Bernecker Steffen , Stadler Marc
Published: March 2016

The two isolated fatty acid styryl amides, endonamides A (Ia) and B (Ib), do not show inhibitory activity against different bacteria, fungi, and cell lines.
ChemInform Abstract: Highly Efficient Nonprecious Metal Catalysts Towards Oxygen Reduction Reaction Based on Three‐Dimensional Porous Carbon Nanostructures
Authors: Zhu Chengzhou , Li He , Fu Shaofang , Du Dan , Lin Yuehe
Published: March 2016

Review: 50 refs.
ChemInform Abstract: Nanoarchitectures for Mesoporous Metals
Authors: Malgras Victor , Ataee‐Esfahani Hamed , Wang Hongjing , Jiang Bo , Li Cuiling , Wu Kevin C.‐W. , Kim Jung Ho , Yamauchi Yusuke
Published: March 2016

Review: 149 refs.
ChemInform Abstract: A Route for Phase Control in Metal Nanoparticles: A Potential Strategy to Create Advanced Materials
Authors: Kusada Kohei , Kitagawa Hiroshi
Published: March 2016

Review: 124 refs.
ChemInform Abstract: Rare‐Earth Metal Oxo/Hydroxo Clusters — Synthesis, Structures, and Applications
Authors: Wagner Anna T. , Roesky Peter W.
Published: March 2016

Review: 122 refs.
ChemInform Abstract: Covalently‐Linked Polyoxometalate—Polymer Hybrids: Optimizing Synthesis, Appealing Structures and Prospective Applications
Authors: Wu Han , Yang Hai‐Kuan , Wang Wei
Published: March 2016

Review: 69 refs.
ChemInform Abstract: Using Carbon Dioxide as a Building Block in Organic Synthesis
Authors: Liu Qiang , Wu Lipeng , Jackstell Ralf , Beller Matthias
Published: March 2016

Review: 100 refs.
ChemInform Abstract: Beyond Protecting Groups in Metal Catalyzed C‐C Coupling: Direct Anomeric Propargylation of Aldoses
Authors: Hong Suckchang , Krische Michael J.
Published: March 2016

Review: [9 refs.
ChemInform Abstract: Azobenzenes and Catalysis
Authors: Leonard Estelle , Mangin Floriane , Villette Carole , Billamboz Muriel , Len Christophe
Published: March 2016

Review: access to diazo compounds (data from 2010) as well as their use as a reactant r a promoter in organometallic catalysis; 172 refs.
ChemInform Abstract: Taming the Reactivity of Glycosyl Iodides to Achieve Stereoselective Glycosidation
Authors: Gervay‐Hague Jacquelyn
Published: March 2016

Review: 41 refs.
ChemInform Abstract: Synthetic Transformations Through Alkynoxy‐Palladium Interactions and C‐H Activation
Authors: Minami Yasunori , Hiyama Tamejiro
Published: March 2016

Review: [34 refs.
ChemInform Abstract: Transition Metal‐Free One‐Pot Synthesis of Nitrogen‐Containing Heterocycles
Authors: Kumari Simpal , Kishore Dharma , Paliwal Sarvesh , Chauhan Rajani , Dwivedi Jaya , Mishra Aakanksha
Published: March 2016

Review: 266 refs.
ChemInform Abstract: The Molecular Diversity Scope of 1,3‐Indandione in Organic Synthesis
Authors: Asadi Shima , Mohammadi Ziarani Ghodsi
Published: March 2016

Review: 146 refs.
ChemInform Abstract: A Sustainable Approach for Lignin Valorization by Heterogeneous Photocatalysis
Authors: Li Shao‐Hai , Liu Siqi , Colmenares Juan Carlos , Xu Yi‐Jun
Published: March 2016

Review: [104 refs.
ChemInform Abstract: Review: Nanocelluloses as Versatile Supports for Metal Nanoparticles and Their Applications in Catalysis
Authors: Kaushik Madhu , Moores Audrey
Published: March 2016

Review: 169 refs.
ChemInform Abstract: Poly(1,2,3‐triazolium)s: A New Class of Functional Polymer Electrolytes
Authors: Obadia Mona M. , Drockenmuller Eric
Published: March 2016

Review: 124 refs.
ChemInform Abstract: Recent Progress in Dehydro(genative) Diels—Alder Reaction
Authors: Li Wenbo , Zhou Liejin , Zhang Junliang
Published: March 2016

Review: [45 refs.
ChemInform Abstract: Environmental Behaviors and Toxicities of Polycyclic Aromatic Hydrocarbons and Nitropolycyclic Aromatic Hydrocarbons
Authors: Hayakawa Kazuichi
Published: March 2016

Review: 63 refs.
ChemInform Abstract: Recent Advances in the Chemistry of Organic Thiocyanates
Authors: Castanheiro Thomas , Suffert Jean , Donnard Morgan , Gulea Mihaela
Published: March 2016

Review: [different methods for the preparation of organic thiocyanates and their synthetic applications; 50 refs.
ChemInform Abstract: Gold‐Catalyzed Transformations of α‐Diazocarbonyl Compounds: Selectivity and Diversity
Authors: Liu Lu , Zhang Junliang
Published: March 2016

Review: 49 refs.
ChemInform Abstract: Using Photo‐Initiated Polymerization Reactions to Detect Molecular Recognition
Authors: Kaastrup K. , Sikes H. D.
Published: March 2016

Review: 50 refs.
ChemInform Abstract: Recent Developments of 2‐Aminothiazoles in Medicinal Chemistry
Authors: Das Debasis , Sikdar Papiya , Bairagi Moumita
Published: March 2016

Review: 81 refs.
ChemInform Abstract: The Applications of Dimethyl Sulfoxide as Reagent in Organic Synthesis
Authors: Wu Xiao‐Feng , Natte Kishore
Published: March 2016

Review: [main developments in the use of DMSO as a source of ‐Me, ‐S‐Me, ‐SO2‐Me, and as an oxidant; 80 refs.
ChemInform Abstract: Prospective of Curcumin, a Pleiotropic Signalling Molecule from Curcuma longa in the Treatment of Glioblastoma
Authors: Luthra Pratibha Mehta , Lal Neetika
Published: March 2016

Review: 132 refs.
ChemInform Abstract: PI3K/Akt/mTOR and Ras/Raf/MEK/ERK Signaling Pathways Inhibitors as Anticancer Agents: Structural and Pharmacological Perspectives
Authors: Asati Vivek , Mahapatra Debarshi Kar , Bharti Sanjay Kumar
Published: March 2016

Review: 156 refs.
ChemInform Abstract: Small‐Molecule PROTACS: New Approaches to Protein Degradation
Authors: Toure Momar , Crews Craig M.
Published: March 2016

Review: [42 refs.
ChemInform Abstract: Potential Antimicrobial Activities of Quinazolinone Derivatives
Authors: Raju Gollapalli Naga , Sai Karumudi Bhavya , Resshma Vallampatla , Sudarshini Nallapu , Sowmya Peruru Lakshmi , Nalini Yekula , Nadendla Rama Rao
Published: March 2016

Review: 44 refs.
ChemInform Abstract: Advances in Nanomaterial Based Approaches for Enhanced Fluoride and Nitrate Removal from Contaminated Water
Authors: Suriyaraj S. P. , Selvakumar R.
Published: March 2016

Review: 195 refs.
ChemInform Abstract: Organic—Inorganic Hybrid Lead Halide Perovskites for Optoelectronic and Electronic Applications
Authors: Zhao Yixin , Zhu Kai
Published: March 2016

Review: 374 refs.
ChemInform Abstract: Silicon Nanocrystals and Silicon‐Polymer Hybrids: Synthesis, Surface Engineering, and Applications
Authors: Dasog Mita , Kehrle Julian , Rieger Bernhard , Veinot Jonathan G. C.
Published: March 2016

Review: [101 refs.
ChemInform Abstract: Preparation and Applications of Novel Composites Composed of Metal—Organic Frameworks and Two‐Dimensional Materials
Authors: Li Shaozhou , Yang Kai , Tan Chaoliang , Huang Xiao , Huang Wei , Zhang Hua
Published: March 2016

Review: 88 refs.
ChemInform Abstract: A Perspective on Bioethanol Production from Biomass as Alternative Fuel for Spark Ignition Engine
Authors: Sebayang A. H. , Masjuki H. H. , Ong Hwai Chyuan , Dharma S. , Silitonga A. S. , Mahlia T. M. I. , Aditiya H. B.
Published: March 2016

Review: 279 refs.
ChemInform Abstract: A Brief Overview on Co‐Crystals and Their Pharmaceutical Applications
Authors: Sarangi Manoj Kumar
Published: March 2016

Review: 50 refs.
ChemInform Abstract: Discotic Liquid Crystals
Authors: Laschat Sabine , et al.
Published: March 2016

Review: 677 refs.
ChemInform Abstract: Recent Developments of Smart Electromagnetic Absorbers Based Polymer‐Composites at Gigahertz Frequencies
Authors: Idris Fadzidah Mohd. , Hashim Mansor , Abbas Zulkifly , Ismail Ismayadi , Nazlan Rodziah , Ibrahim Idza Riati
Published: March 2016

Review: 148 refs.
Optische Prozessanalysatoren für die Lebensmittelindustrie
Authors: Zettel Viktoria , Ahmad Muhammad Haseeb , Hitzemann Annika , Nache Marius , Paquet‐Durand Olivier , Schöck Thomas , Hecker Florian , Hitzmann Bernd
Published: March 2016

Die Innovationsfreude der Lebensmittelindustrie wird als gering eingestuft, obgleich sie in Deutschland die viertgrößte Industriebranche darstellt. Jedoch sind die Herausforderungen in der Lebensmittelindustrie deutlich größer als zum Beispiel in der chemischen Industrie. Die Rohstoffe sind meist komplexer und an ihre Verarbeitung werden zumeist höhere Anforderungen gestellt. Am Beispiel von optischen Messverfahren wird das Potenzial der Prozessanalytik zur Bereitstellung von Informationen über Rohstoffe, Zwischen‐ und Endprodukte von Lebensmittelherstellungsprozessen dargestellt.
Synthesis and characterization of copper succinate and copper oxide nanoparticles by electrochemical treatment: Optimization by Taguchi robust analysis
Authors: Das Susmita , Srivastava Vimal Chandra
Published: March 2016

Cylindrical rod‐shaped copper succinate nanoparticles were prepared using the electrochemical method. Taguchi robust design was applied to optimize experimental parameters such as succinic ion concentration (Co), current applied (Iap), and pH (pH). The obtained copper succinate nano‐rods were further thermally treated at different temperatures to produce copper oxide (CuO) nano‐disks. At optimum conditions of Iap = 0.5 A, pH = 7, and Co = 0.25, the maximum productivity of copper nanoparticles before and after calcination at 500 °C was 1.53 g and 1.06 g, respectively. Products were characterized by Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and UV‐visible spectrophotometry to determine their various physicochemical characteristics.
How do you write and present research well? 8 — Assign authorship according to intellectual involvement
Authors: Boffito Daria C. , Patience Christian A. , Patience Paul A. , Bertrand François , Patience Gregory S.
Published: March 2016

What are the minimum requirements for co‐authorship?[1,2]

conceive and design the study (or parts of it)

collect and analyze data

interpret data

draft the article

revise parts of it

approve the final version

agree to be accountable for the results

ii), iv), vi), vii)

i), ii), iv)

iii), v)

vi), vii)

Other combinations of correct answers:

i) iv) vi) vii)

i) v) vi) vii)

ii) v) vi) vii)

iii) iv) vi) vii)

iii) v) vi) vii)
Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P‐Glycoprotein (P‐gp) and Breast Cancer Resistance Protein (BCRP)
Authors: Schwarz Theresa , Montanari Floriane , Cseke Anna , Wlcek Katrin , Visvader Lene , Palme Sarah , Chiba Peter , Kuchler Karl , Urban Ernst , Ecker Gerhard F.
Published: March 2016

The transmembrane ABC transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) are widely recognized for their role in cancer multidrug resistance and absorption and distribution of compounds. Furthermore, they are linked to drug–drug interactions and toxicity. Nevertheless, due to their polyspecificity, a molecular understanding of the ligand‐transporter interaction, which allows designing of both selective and dual inhibitors, is still in its infancy. This study comprises a combined approach of synthesis, in silico prediction, and in vitro testing to identify molecular features triggering transporter selectivity. Synthesis and testing of a series of 15 propafenone analogues with varied rigidity and basicity of substituents provide first trends for selective and dual inhibitors. Results indicate that both the flexibility of the substituent at the nitrogen atom, as well as the basicity of the nitrogen atom, trigger transporter selectivity. Furthermore, inhibitory activity of compounds at P‐gp seems to be much more influenced by logP than those at BCRP. Exploiting these differences further should thus allow designing specific inhibitors for these two polyspecific ABC‐transporters.
Recent Development of Benzimidazole‐Containing Antibacterial Agents
Authors: Song Di , Ma Shutao
Published: March 2016

Clinically significant antibiotic resistance is one of the greatest challenges of the twenty‐first century. However, new antibacterial agents are currently being developed at a much slower pace than our growing need for such drugs. Given their diverse biological activities and clinical applications, many bioactive heterocyclic compounds containing a benzimidazole nucleus have been the focus of interest for many researchers. The benzimidazole nucleus is a structural isostere of naturally occurring nucleotides. This advantage allows benzimidazoles to readily interact with the various biopolymers found in living systems. In view of this situation, much attention has been given to the exploration of benzimidazole‐based antibacterial agents, leading to the discovery of many new chemical entities with intriguing profiles. In this minireview we summarize novel benzimidazole derivatives active against various bacterial strains. In particular, we outline the relationship between the structures of variously modified benzimidazoles and their antibacterial activity.
Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first‐line treatment of patients with advanced HER2‐negative gastric cancer: A multicenter phase 2 study
Authors: Meulendijks Didier , de Groot Jan Willem B. , Los Maartje , Boers James E. , Beerepoot Laurens V. , Polee Marco B. , Beeker Aart , Portielje Johanna E.A. , Goey Swan H. , de Jong Robert S. , Vanhoutvin Steven A.L.W. , Kuiper Maria , Sikorska Karolina , Pluim Dick , Beijnen Jos H. , Schellens Jan H.M. , Grootscholten Cecile , Tesselaar Margot E.T. , Cats Annemieke
Published: March 2016

BACKGROUND

The current study was a multicenter, single‐arm, phase 2 study performed to investigate the feasibility and efficacy of bevacizumab combined with docetaxel, oxaliplatin, and capecitabine (B‐DOC) in patients with advanced human epidermal growth factor receptor 2 (HER2)‐negative, previously untreated, gastric or gastroesophageal adenocarcinoma.

METHODS

Tumor HER2 status was determined centrally. Patients received 6 cycles of bevacizumab at a dose of 7.5 mg/kg, docetaxel at a dose of 50 mg/m2, and oxaliplatin at a dose of 100 mg/m2 (all on day 1) combined with capecitabine at a dose of 850 mg/m2 twice daily (days 1‐14) every 3 weeks followed by maintenance with capecitabine and bevacizumab in patients with disease control. The primary objective was to demonstrate a progression‐free survival (PFS) of >6.5 months, according to the 95% confidence interval (95% CI). Secondary endpoints included safety, objective response rate, overall survival (OS), analyses of circulating tumor cells (CTCs), and pharmacogenetic analyses.

RESULTS

Sixty eligible patients were enrolled. The median PFS was 8.3 months (95% CI, 7.2‐10.9 months). The objective response rate was 70% (95% CI, 55%‐83%) and the disease control rate was 96% (95% CI, 85%‐99%). The median OS was 12.0 months (95% CI, 10.2‐16.1 months). According to CTC‐AE v4.0, the most common treatment‐related grade ≥3 adverse events were neutropenia (20%), leukocytopenia (18%), diarrhea (15%), and nausea/vomiting (15%). The presence of CTCs at baseline was strongly predictive of PFS (hazard ratio [HR], 3.8; P =.007) and OS (HR, 3.4; P =.014). The methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype was strongly associated with PFS (HR, 4.7 for TT vs CC or CT; P =.0007) and OS (HR, 5.9; P =.0001).

CONCLUSIONS

The B‐DOC regimen plus maintenance was feasible and active. CTCs were found to be prognostic in patients treated with B‐DOC. Docetaxel‐based triplet chemotherapy as a backbone for targeted therapies is feasible and deserves further study. Cancer 2016;122:1434–1443. © 2016 American Cancer Society.
Web‐based collaborative care intervention to manage cancer‐related symptoms in the palliative care setting
Authors: Steel Jennifer L. , Geller David A. , Kim Kevin H. , Butterfield Lisa H. , Spring Michael , Grady Jonathan , Sun Weiing , Marsh Wallis , Antoni Michael , Dew Mary Amanda , Helgeson Vicki , Schulz Richard , Tsung Allan
Published: March 2016

BACKGROUND

The aim of this study was to examine the efficacy of a collaborative care intervention in reducing depression, pain, and fatigue and improve quality of life.

METHODS

A total of 261 patients with advanced cancer and 179 family caregivers were randomized to a web‐based collaborative care intervention or enhanced usual care. The intervention included the following: 1) a web site with written and audiovisual self‐management strategies, a bulletin board, and other resources; 2) visits with a care coordinator during a physician's appointment every 2 months; and 3) telephone follow‐up every 2 weeks. Primary patient outcomes included measures of depression, pain, fatigue, and health‐related quality of life. Secondary outcomes included Interleukin (IL)‐1α, IL‐1β, IL‐6, and IL‐8 levels, Natural Killer (NK) cell numbers, and caregiver stress and depression.

RESULTS

At the baseline, 51% of the patients reported 1 or more symptoms in the clinical range. For patients who presented with clinical levels of symptoms and were randomized to the intervention, reductions in depression (Cohen's d = 0.71), pain (Cohen's d = 0.62), and fatigue (Cohen's d = 0.26) and improvements in quality of life (Cohen's d = 0.99) were observed when compared to those in the enhanced usual car arm at 6 months. Reductions in IL‐6 (φ = 0.18), IL‐1β (φ = 0.35), IL‐1α (φ = 0.19), and IL‐8 (φ = 0.15) and increases in NK cell numbers (φ = 0.23) were observed in comparison with enhanced usual care arm at 6 months. Reductions in caregiver stress (Cohen's d = 0.75) and depression (Cohen's d = 0.37) were observed at 6 months for caregivers whose loved ones were randomized to the intervention arm.

CONCLUSIONS

The integration of screening and symptom management into cancer care is recommended. Cancer 2016;122:1270–82. © 2016 American Cancer Society.
Number of positive nodes is superior to the lymph node ratio and American Joint Committee on Cancer N staging for the prognosis of surgically treated head and neck squamous cell carcinomas
Authors: Roberts Thomas J. , Colevas A. Dimitrios , Hara Wendy , Holsinger F. Christopher , Oakley‐Girvan Ingrid , Divi Vasu
Published: March 2016

BACKGROUND

Recent changes in head and neck cancer epidemiology have created a need for improved lymph node prognostics. This article compares the prognostic value of the number of positive nodes (pN) with the value of the lymph node ratio (LNR) and American Joint Committee on Cancer (AJCC) N staging in surgical patients.

METHODS

The Surveillance, Epidemiology, and End Results database was used to identify cases of head and neck squamous cell carcinomas from 2004 to 2012. The sample was grouped by the AJCC N stage, LNR, and pN and was analyzed with Kaplan‐Meier and multivariate Cox proportional hazards models. The sample was also analyzed by the site of the primary tumor.

RESULTS

This study identified 12,437 patients. Kaplan‐Meier survival curves showed superior prognostic ability for LNR and pN staging in comparison with AJCC staging. Patients with a pN value > 5 had the worst overall survival (5‐year survival rate, 16%). Patients with oropharyngeal tumors had better outcomes for all groupings, and a pN value > 5 for oropharyngeal cancers was associated with decreased survival. Multivariate regressions demonstrated larger hazard ratios (HRs) and a lower Akaike information criterion for the pN model versus the AJCC stage and LNR models. The HRs were 1.78 (95% confidence interval, 1.62‐1.95) for a pN value of 1, 2.53 (95% confidence interval, 2.32‐2.75) for a pN value of 2 to 5, and 4.64 (95% confidence interval, 4.18‐5.14) for a pN value > 5.

CONCLUSIONS

The pN models demonstrated superior prognostic value in comparison with the LNR and AJCC N staging. Future modifications of the nodal staging system should be based on the pN with a separate system for oropharyngeal cancers. Future trials should consider examining adjuvant treatment escalation in patients with >5 lymph nodes. Cancer 2016;122:1388–1397. © 2016 American Cancer Society.
Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients
Authors: Song Young Shin , Lim Jung Ah , Choi Hoonsung , Won Jae‐Kyung , Moon Jae Hoon , Cho Sun Wook , Lee Kyu Eun , Park Young Joo , Yi Ka Hee , Park Do Joon , Seo Jeong‐Sun
Published: March 2016

BACKGROUND

Recent reports suggest that mutations in the promoter of the gene encoding telomerase reverse transcriptase (TERT) affect thyroid cancer outcomes.

METHODS

In all, 551 patients with differentiated thyroid cancer (DTC) enrolled in this study. The median follow‐up duration was 4.8 years (interquartile range, 3.4‐10.6 years).

RESULTS

TERT promoter mutations were detected in 25 DTCs (4.5%): 2.8% in neither BRAF‐mutated nor RAS‐mutated tumors, 4.8% in BRAF‐mutated tumors, and 11.3% in RAS‐mutated tumors. Moreover, they were frequently observed in American Thyroid Association (ATA) high‐risk and TNM stage III/IV groups (9.1% and 12.9%, respectively). The coexistence of BRAF or RAS with TERT promoter mutations increased aggressive clinicopathologic features, recurrence (hazard ratio [HR] for BRAF, 4.64; 95% confidence interval [CI], 1.42‐15.18; HR for RAS, 5.36; 95% CI, 1.20‐24.02), and mortality (HR for BRAF, 15.13; 95% CI, 1.55‐148.23; HR for RAS, 14.75; 95% CI, 1.30‐167.00), even after adjustments for the age at diagnosis and sex, although the significance was lost after additional adjustments for pathologic characteristics. Furthermore, TERT promoter mutations significantly increased the risk of both recurrence and mortality in the ATA high‐risk (HR for recurrence, 5.79; 95% CI, 2.07‐16.18; HR for mortality, 16.16; 95% CI, 2.10‐124.15) and TNM stage III/IV groups (HR for recurrence, 3.60; 95% CI, 1.19‐10.85; HR for mortality, 9.06; 95% CI, 2.09‐39.26).

CONCLUSIONS

The coexistence of BRAF or RAS mutations enhanced the prognostic effects of TERT promoter mutations. Furthermore, TERT promoter mutations strengthened the predictions of mortality and recurrence by the ATA and TNM staging systems, particularly for high‐risk patients with DTC. Cancer 2016;122:1370–1379. © 2016 American Cancer Society.
Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base
Authors: Cracchiolo Jennifer R. , Baxi Shrujal S. , Morris Luc G. , Ganly Ian , Patel Snehal G. , Cohen Marc A. , Roman Benjamin R.
Published: March 2016

BACKGROUND

There has been increasing interest in the primary surgical treatment of patients with early T classification (T1‐T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de‐escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features.

METHODS

Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation‐based treatment. Trends in treatment selection and factors related to the selection of primary surgery were examined. The rates of adverse pathologic features including positive surgical margins, extracapsular spread (ECS), and advanced T and N classifications after surgery were analyzed.

RESULTS

Of 8768 patients with T1 to T2 OPSCC, 68% underwent primary surgical treatment, increasing from 56% in 2004 to 82% in 2013 (P<.0001). The highest versus lowest volume hospitals treated 78% versus 59% of patients with primary surgery (odds ratio, 2.23; 95% confidence interval, 1.55‐3.22 [P<.0001]). Higher lymph node classification was found to be predictive of lower rates of primary surgery, but the majority of patients with clinical N2/N3 disease underwent primary surgery. Among patients treated with surgery, positive surgical margins were present in 24% and ECS in 25% of patients. The rate of positive surgical margins decreased over time (P<.0001) and was observed less often at high‐volume centers (P<.0001). Among candidates for single‐modality therapy (those with clinical T1‐T2/N0‐N1 disease), 33% had positive surgical margins and/or ECS and 47% had at least 1 adverse feature (T3‐T4 disease, N2‐N3 disease, positive surgical margins, and/or ECS).

CONCLUSIONS

Primary surgical treatment among patients with early T classification OPSCC has become more widespread. Cancer 2016;122:1523–32. © 2016 American Cancer Society.