bluuebunny/crossref_metadata_2025 huggingface dataset:
Perluasan potensi pasar produk lokal dengan e-commerce pada pelaku usaha mikro, kecil, dan menengah (UMKM)
Authors: Widyastuti Liza Yudhita , Maulana Herdiyan , Erik Erik , Izzah Khalid Ahmad , Azzahra Yulia Chaerani
Published: November 2023

Desa Pasirtanjung, Kabupaten Bogor memiliki potensi ekonomi berupa industri kreatif yang berskala usaha mikro, kecil, dan menengah (UMKM). Akan tetapi, terdapat beberapa masalah prioritas yang dihadapi desa ini yakni dalam pemberdayaan sumber daya manusia yang bertumpu pada UMKM setempat. UMKM Desa Pasirtanjung sebagai sumber penghasilan masyarakat pun memiliki masalah dalam hal potensi pasar yang terbatas dan kurang berkembang seperti pada bidang kerajinan tangan (contoh:  tas dan produk kulit). Tim Fakultas Pendidikan Psikologi Universitas Negeri Jakarta (FPPsi UNJ), melalui program kegiatan pengabdian kepada masyarakat dengan metode community development, berupaya memfasilitasi pelaku UMKM. Pelaku UMKM sebagai peserta diberikan peningkatan pengetahuan melalui pelatihan tentang pengenalan e-commerce. Adapun konten yang diberikan yaitu mengenai pengetahuan pentingnya penggunaan e-commerce, cara menggunakan dan membuka toko online, mengemas pemasaran produk yang menarik di e-commerce melalui copywriting dan foto produk, serta cara mengelolanya secara optimal. Dari hasil evaluasi yang didapatkan, program pengabdian kepada masyarakat ini dikatakan efektif. Terdapat peningkatan pengetahuan dalam hal pemanfaatan e-commerce sebesar 5.3% dan 100% peserta pelatihan telah mencoba mengaplikasikan e-commerce pada usahanya. Agar implementasi penggunaan e-commerce lebih optimal, perlu dilakukan pendampingan lebih lanjut bekerja sama dengan pemerintah setempat. Dengan ini UMKM Desa Pasirtanjung dapat lebih mandiri dalam memperluas pasar, ke luar kota bahkan ke seluruh Indonesia.
Menuju lingkungan berbudaya: Revolusi hijau melalui bank sampah komunitas
Authors: Kurniawan Zaqi , Indra Indra , Hadidtyo Wisnu Wardani
Published: November 2023

Kesadaran akan perlunya melestarikan lingkungan semakin penting, terutama di wilayah urban seperti Komplek Jurang Manggu Timur, Pondok Aren, Tangerang Selatan. Dalam konteks ini, sebuah workshop pengabdian masyarakat difokuskan pada inisiatif utama yaitu Bank Sampah. Tujuannya adalah meningkatkan kesadaran serta keterlibatan masyarakat dalam menjaga lingkungan. Pendekatan kolaboratif diadopsi untuk merespons masalah sampah dan kurangnya kesadaran lingkungan. Workshop ini bertujuan mengubah pola pikir dan tindakan masyarakat menuju praktik berkelanjutan dalam menjaga lingkungan, didasarkan pada pendekatan pengembangan komunitas. Partisipasi aktif dari masyarakat, pemerintah, dan perguruan tinggi menjadi kunci dalam perencanaan program ini. Diskusi dan konsultasi membentuk landasan kuat dengan tujuan yang jelas dan strategi pelaksanaan inklusif. Hasilnya menunjukkan tingkat kehadiran peserta mencapai 80% dan penurunan jumlah sampah hingga 50%, mencerminkan efektivitas pendekatan kolaboratif. Keberhasilan workshop ini menunjukkan bahwa pendekatan pengembangan komunitas, melalui Bank Sampah dan Taman Bacaan, berhasil meningkatkan kesadaran dan partisipasi masyarakat dalam melestarikan lingkungan serta menggalakkan minat baca. Kolaborasi erat antara berbagai pihak terbukti memberikan dampak positif yang signifikan, menjadi langkah penting dalam mendukung pelestarian lingkungan yang berkelanjutan.
Penerapan community based tourism di desa wisata mengarah pada keberlanjutan lingkungan
Authors: Alimi Rosma , Darwis Rudi Saprudin
Published: November 2023

Community Development merupakan salah satu upaya untuk mewujudkan pembangunan berkelanjutan di Indonesia. Pembangunan berkelanjutan harus mampu memberikan solusi dalam hal memenuhi kebutuhan dasar manusia, mengintegrasikan pembangunan dengan perlindungan lingkungan, mencapai kesetaraan, memastikan penentuan nasib sendiri, keanekaragaman sosial dan budaya, dan memelihara integritas ekologi. Pembangunan berkelanjutan menjadi salah satu upaya untuk mempromosikan pariwisata berkelanjutan melalui tiga pilar yang terdiri dari keberlanjutan ekonomi, keberlanjutan sosial, dan keberlanjutan lingkungan. Community Based Tourism (CBT) pada dasarnya merupakan upaya pengembangan suatu pariwisata melalui pemberdayaan masyarakat lokal dengan adanya keterlibatan masyarakat dalam perencanaan, pengelolaan hingga keputusan dalam pembangunan pariwisata. Melalui desa wisata diharapkan dapat menumbuhkan pemerataan sesuai dengan konsep pembangunan pariwisata berkelanjutan. Penelitian mengenai penerapan pariwisata berbasis masyarakat di desa wisata mengarah pada keberlanjutan lingkungan diteliti menggunakan metode Community Development dengan strategi Community Based Tourism (CBT) dan dianalisis menggunakan salah satu pilar pembangunan berkelanjutan yaitu keberlanjutan lingkungan. Untuk kriteria integritas ekosistem terdapat penanaman pohon dan pengelolaan sampah. Selanjutnya, kriteria daya dukung terdapat jarak dan posisi rumah yang kurang sesuai, adanya fasilitas yang nyaman dan terjadi eksploitasi hutan. Kemudian, kriteria kesadaran akan konservasi terdapat kegiatan sosialisasi dan lomba Pemanfaatan Pekarangan. Desa Gedepangrango merupakan salah satu desa di Kecamatan Kadudampit Kabupaten Sukabumi yang telah dikembangkan menjadi desa wisata pada tahun 2019 oleh Kementrian Pariwisata dan Ekonomi Kreatif (Kemenparekraf). Keberlanjutan lingkungan meliputi integritas ekosistem, daya dukung dan keanekaragaman hayati. Penerapan Community Based Tourism (CBT) di Desa Gedepangrango masih pada tahap cenderung mengarah pada pembangunan berkelanjutan jika pengembangan pariwisata terus ditingkatkan karena saat ini Desa Gedepangrango masih dalam tahap pengembangan dan pembangunan destinasi wisata yang dapat dikelola oleh Masyarakat.
Pendampingan belajar berbasis komunitas dan gerakan menabung sejak dini untuk masa depan anak di pedesaan
Authors: Pebriani Reny Aziatul , Sari Rafika
Published: November 2023

Kegiatan Pengabdian kepada Masyarakat yang dilakukan dalam kkn tematik dosen dan mahasiswa universitas IGM di Kecamatan Lembak, Kabupaten Muara Enim. Pendidikan yang berkualitas merupakan kebutuhan mendasar bagi perkembangan anak-anak di pedesaan. Namun, di Desa Kemang, akses terhadap pendidikan yang optimal masih menjadi tantangan. Masalah ini mendorong munculnya inisiatif pendampingan belajar berbasis komunitas dan gerakan menabung sejak dini sebagai langkah konkret dalam menciptakan masa depan yang lebih cerah bagi generasi mendatang di desa ini. Tujuan dari kegiatan ini diterapkan melalui sinergi antara pendampingan belajar berbasis komunitas dan gerakan menabung sejak dini, diharapkan generasi anak-anak Desa Kemang dapat memiliki kesempatan yang lebih baik untuk meraih cita-cita dan membangun masa depan yang lebih cerah. Dukungan aktif dari orang tua, guru, dan seluruh masyarakat di Desa Kemang menjadi kunci keberhasilan dari inisiatif ini dalam menciptakan anak-anak yang cerdas, mandiri, dan siap menghadapi masa depan dengan percaya diri. Metode yang digunakan dalam pengabdian ini adalah metode service learning dengan terjun dan memberikan pendamingan secara langsung untuk Pendidikan berbasis komunitas dan Gerakan menabung sejak dini terhadap anak anak dan orang tua yang mendampingi, hasil dari pengabdian ini memberikan peningkatan akan kemauan belajar dengan Gerakan berbasis komunitas dan Gerakan menabung sejak dini anak anak desa kemang.
Aplikasi teknologi tepat guna pengolahan air sebagai sumber air bersih masyarakat
Authors: Khayan  , Ihsan Bagus Muhammad , Sucipto Cecep Dani , Puspita Widyana Lakshmi
Published: November 2023

Gangguan kesehatan di Indonesia yang berhubungan dengan penyakit yang ditularkan melalui air (Water Borne Disease) masih tergolong tinggi, seperti Diare dan hepatitis. Timbulnya penyakit menular terkait Water Borne Disease tersebut, diantaranya karena tidak terpenuhinya kuantitas dan kualitas air baku sebagai sumber air minum yang memenuhi syarat kesehatan. Metode pengabdian masyarakat ini dilakukan beberapa metode, yaitu pendekatan masyarakat, penyuluhan dan pembuatan sarana Pengolahan Air Permukaan dengan Teknologi Tepat Guna (TTG) kombinasi, yaitu dengan Aerasi, Filtrasi Pasir dan Absorpsi Kabon Aktif untuk Menurunkan kandungan Fe, Kekeruhan, Warna dan pH Air permukaan sebagai sumber air minum masyarakat di Desa Pranan Kota Serang. Hasil dan kesimpulan dari pengabdian pada masyarakat ini adalah Terdapat peningkatan pengetahuan masyarakat tentang TTG Filtrasi Air Bersih , Terciptanya revitalisasi sumber air bersih, transfer teknologi serta dampak sosial bagi masyarakat yaitu perubahan pola kegiatan mandi dan mencuci yang sebelumnya dilakukan di kali pembuangan air sawah setelah pelaksanaan pengabdian kegiatan tersebut beralih ke rumah masing-masing dan Metode penjernihan air secara filtrasi terbukti dapat meningkatkan kualitas air sumur bor ,sehingga air berada pada ambang batas layak digunakan untuk kehidupan sehari-hari. Dengan ini masyarakat setempat tidak lagi mengambil air dari sungai pembuangan air sawah.
Meningkatkan religiusitas masyarakat melalui kajian hadis dan wirid ratib al-haddad
Authors: Faisol  , Mustofa Syaiful , Maftukhah Nuriatul , Ungu Fabilla Nimas Wedhari
Published: November 2023

Kualitas sumber daya manusia menentukan tingkat pemahaman keagamaan masyarakat. Rendahnya kesadaran beragama, perilaku budaya pendatang lebih dominan, serta kurangnya peran tokoh masyarakat menyebabkan rendahnya religiusitas masyarakat Merjosari. Penelitian ini merupakan jenis penenlitian kualitiatif menggunakan pendekatan Participatory Action Research (PAR) yaitu antara subjek penelitian dan peneliti sebagai pemantik. Peneliti menggali data malalui pengamatan mendalam dan wawancara. Data dianalisis secara deskriptif untuk ditarik simpulan. Tujuan dari penelitian ini adalah mengetahui pemahaman kitab kuning, penghayatan keagamaan, serta peningkatan kualitas sikap religius masyarakat Merjosari terhadap Kitab Bulughul Maram dan Wirid Ratib al-Haddad. Hasil dari penelitian ini menunjukkan meningkatnya religiusitas masyarakat Merjosari dapat dilihat dari intensitas dan kuantitas pelaksanaan ibadah shalat lima waktu dan shalat sunnah lainnya di dalam masjid. Religiusitas masyarakat dapat dilihat dari lingkungan yang bersih dari pergaulan bebas antara lawan jenis, keseriusan masyarakat mengikuti kajian kitab dan bacaan wirid,  juga permintaan kuat untuk terus dilaksanakan kajian kitab dan bacaan wirid setiap hari.
Sertifikasi halal sebagai nilai tambah inovasi produk UMKM unggulan
Authors: Yasin Rozaq Muhammad , Fahira Keke Tamara , Alpandari Heny
Published: November 2023

Pemerintah melalui BPJPH mengatakan bahwa seluruh produk makanan dan minuman harus tersertifikasi halal maksimal 17 Oktober 2024. Pada kenyataannya banyak UMKM yang tidak mengetahui terutama UMKM di sekitar lereng gunung Muria. UMKM mitra yaitu Recolta Parijoto masih minim pengetahuan tentang pentingnya sertifikasi halal produk dan inovasi produk olahan. Kondisi tersebut berdampak pada kemungkinan tutupnya suatu usaha atau adanya pengambil alihan branding atas produk Robusta Muria dan Parijoto dari daerah lain. Padahal Robusta Muria dan Parijoto termasuk produk hasil pertanian yang menjadi unggulan/ciri khas dari Gunung Muria. Metode yang digunakan dalam pengabdian ini yaitu metode Asset Based Community Development (ABCD). Teknis pelaksanaan pengabdian ini meliputi 1) Sosialisasi; 2) Pendampingan; 3) Pelatihan; dan 4) Monitoring dan Evaluasi yang bertujuan untuk meningkatkan pemahaman dan kesadaran mitra. Luaran kegiatan ini yaitu inovasi produk olahan, produk mitra sudah tersertifikasi halal, serta kemampuan mitra dalam menciptakan inovasi-inovasi baru agar lebih memiliki nilai tambah. Melalui kepemilikan sertifikasi halal, inovasi produk baru menjadikan mitra lebih percaya diri dan mampu menjangkau pasar yang lebih luas. Rencana tindak lanjut dari pengabdian ini yaitu seluruh produk hasil olahan mitra akan di daftarkan sertifikasi halal selama program SEHATI masih dibuka.
Vulnerability of the Critically Endangered leatherback turtle to fisheries bycatch in the eastern Pacific Ocean. I. A machine-learning species distribution model
Authors: Lopez J , Griffiths S , Wallace BP , Cáceres V , Helena Rodríguez L , Abrego M , Alfaro-Shigueto J , Andraka S , José Brito M , Camila Bustos L , Cari I , Carvajal JM , Clavijo L , Cocas L , de Paz N , Herrera M , Mangel JC , Pérez-Huaripata M , Piedra R , Quiñones Dávila JA , Rendón L , Rguez-Baron JM , Santana H , Suárez J , Veelenturf C , Vega R , Zárate P
Published: November 2023

The Eastern Pacific population of leatherback turtles Dermochelys coriacea is Critically Endangered, with incidental capture in coastal and pelagic fisheries as one of the major causes. Given the population’s broad geographic range, status, and extensive overlap with fisheries throughout the region, identifying areas of high importance is essential for effective conservation and management. In this study, we created a machine-learning species distribution model trained with remotely sensed environmental data and fishery-dependent leatherback presence (n = 1088) and absence data (>500000 fishing sets with no turtle observations) from industrial and small-scale fisheries that operated in the eastern Pacific Ocean between 1995 and 2020. The data were obtained through a participatory collaboration between the Inter-American Convention for the Protection and Conservation of Sea Turtles and the Inter-American Tropical Tuna Commission as well as non-governmental organizations to support the quantification of leatherback vulnerability to fisheries bycatch. A daily process was applied to predict the probability of leatherback occurrence as a function of dynamic and static environmental covariates. Coastal areas throughout the region were highlighted as important habitats, particularly highly productive feeding areas over the continental shelf of Ecuador, Peru, and offshore from Chile, and breeding areas off Mexico and Central America. Our model served as the basis to quantify leatherback vulnerability to fisheries bycatch and the potential efficacy of conservation and management measures (Griffiths & Wallace et al. 2024; Endang Species Res 53:295-326). In addition, this approach can provide a modeling framework for other data-limited vulnerable populations and species.
Building Bridges of Multifaith Awareness
Authors: Triasmoroadi Hardiyan
Published: November 2023

In the face of religious tensions within the Indonesian context, the East Java Christian Church grapples with the imperative question: "How can the church effectively engage with a multifaith world amidst religious and social tensions?" In response to the question, I contend that the church can build its multifaith awareness by adopting a model derived from Javanese tradition, namely jagongan and patuwen, Jagongan embodies communal characteristics, while patuwen signifies personal and private qualities. These Javanese traditions mirror the twofold movement of Jesus—exitus a Deo and exitus a se—reflecting both exit from Father and of Himself leading to a return and entry to the Divine. The church can engage jagongan as an invitation for people to enter and gather in public space and employ patuwen to reach out and exit from the church space to embrace people's private space. I will demonstrate the practical implementation of jagongan and patuwen as spaces for multifaith learning and social justice awareness within the church, presented under the banner of the Festival of Faith. In conclusion, jagongan and patuwen emerge as powerful models for bridging and enriching the church's multifaith awareness, fostering greater understanding, inclusivity, and social justice in the diverse landscape of faith.
Szöveg és kép, író és illusztrátor szimbiózisa angol nyelvű gyermekkönyvekben
Authors: Csizmadia Gábor
Published: November 2023

A tanulmány a gyermekkönyvek szövegei és illusztrációik kapcsolatát, a szerző és művész együttműködésének lehetőségeit és hagyományait tárgyalja, miközben megpróbál betekintést nyújtani az elmúlt két évtizedben a témában megjelent kritikák világába. Bár a gyermekkönyvekkel és illusztrációikkal kapcsolatban keletkezett irodalomelméleti és -kritikai korpusz továbbra is jelentős hivatkozási anyaggal adós, amint azt a téma szószólói gyakran emlegetik, ez a tanulmány a legizgalmasabb vitapontokra szorítkozik. Ezzel a háttérrel tallózik a brit, amerikai és nemzetközi gyerekkönyvek néhány kiemelkedő szereplője történetében, mintegy az elméleti értekezések illusztrációjaként munkásságuk, és a szerző-művész együttműködés érdekes fejleményei kapcsán
Legume yield and persistence when sown in grass and herb pasture mixes in Lees Valley, South Island High Country
Authors: Olykan Sonya , Mills Annamaria , Lucas Richard , Smith Malcolm , Moot Derrick
Published: November 2023

Four experiments were established to identify suitable companion species for legumes grown in the intermontane Basin of the Lees Valley, North Canterbury (400 m a.s.l.). This location experiences long cold winters, has soils of low pH and high aluminium, with low water holding capacity and severe summer soil moisture deficits.

In Year 1, the ryegrass mixtures yielded 4550±290 kg DM/ha more (P<0.05) than the timothy mixtures (3440 kg DM/ha) and the dryland mixture total yield was 4370 kg. The average white clover yield of 1800±210 kg DM/ha was not different among all treatments and represented 43% of total DM, compared with only 8% for sub clover.

Total yield in Year 2 was higher (P<0.05) in the dryland- and ryegrass-based mixtures (~4400±330 kg DM/ha) than timothy (2650 kg). White clover yield across the mixtures was 930±90 kg DM/ha and 29% of the total DM. Sub clover did not re-establish.

White clover yields peaked in October-November of both years with growth rates of ~16 kg DM/ha/d. The start of the summer dry period, from late September onwards, resulted in a decline in white clover spring growth rates and lower yields.

In the Caucasian-herbs experiment, yield in Years 1 and 2 were 2700±250 and 2830±230 kg DM/ha/yr respectively. In both years Caucasian clover yields were lower when grown in herb-based mixtures compared with a monoculture (Year 1: ~400 versus 1800±270 kg DM/ha, Year 2: 920 versus 1750±210 kg DM/ha). The herb content of the mixtures declined over time.
Effect of intermittent pneumatic compression on preventing deep vein thrombosis using microfluidic vein chip
Authors: Dai Hongtao , Chai Senlin , Yao Yao , Tang Wenlai , Shi Jianping , Jiang Qing , Zhu Liya
Published: November 2023

Background: Deep Vein Thrombosis (DVT) is a common disease, frequently afflicting the lower limb veins of bedridden patients. Intermittent Pneumatic Compression (IPC) is often employed as an effective solution for this problem. In our study, a random selection of 264 patients underwent IPC treatment for either one or 8 hours daily. The rate of severe venous thrombosis was substantially reduced in the IPC-treated group compared to the control group. However, real-time monitoring of blood flow during IPC operation periods remains a challenge, leading to rare awareness of IPC working mechanism on thrombosis prevention.

Methods: Here, microfluidic chip methodology is used to create an in vitro vein-mimicking platform integrating venous valves in a deformable channel. Whole blood of patients after knee surgery was perfused into the venous channel at a controlled flow rate obtained from patients with IPC treatment clinically.

Results: According to the numerical simulations results, both of an increase in compressive pressure and a decrease in time interval of IPC device can accelarete blood flow rate and the shear stress within the vein. The vein chip experiments also reveal that the fibrin accumulation can be greatly lowered in IPC treated group, indicating less thrombosis formation in future. A time interval of 24 seconds and a maximum contraction pressure of 40 mmHg were proved to be the most effective parameters for the IPC device adopted in our clinical trail.

Conclusion: This vein chip presents a novel method for observing the functional mechanisms of IPC device for DVT prevention. It provides crucial data for further standardization and optimization of IPC devices in clinical usage.
Relation between learning process and morphology of transport tube network in plasmodium of Physarum polycephalum
Authors: Yoneoka Emiri , Takamatsu Atsuko
Published: November 2023

The question of whether a single-celled organism without a brain could have functions such as learning and memory has been the subject of much debate in recent years. The plasmodium of the true slime mold, Physarum polycephalum, is an ideal model organism for such a question. The plasmodium exhibits behaviors that resemble intelligence, including solving mazes, mimicking optimal rail transportation networks, predicting the weather, and solving traveling salesman problems. In addition, the plasmodium has recently been shown to have the simplest form of learning: habituation. In the experiments in which plasmodia were repeatedly allowed to cross bridges containing aversive chemicals, the habituation behavior has been confirmed. It has been shown that the habituation process involves chemicals that are stored internally. However, it is not clear how these chemicals result in change in the behavior of plasmodium during habituation learning. This study focused on the transport tube network formed in plasmodium during the above experiments. Then, the role of the network morphology in the habituation learning process was investigated. The results showed that the network morphology changes from tree to mesh type during habituation learning, and disrupting the learned network reduces habituation behavior. In addition, it was shown that the thickness oscillation frequency depends on the network morphology. The study found that in the plasmodium of P. polycephalum, a primitive organism without a brain, transport tube networks, instead of neuronal networks, play an important role in habituation learning and the resulting decision making.
Single-cell RNA sequencing reveals cancer stem-like cells and dynamics in tumor microenvironment during cholangiocarcinoma progression
Authors: Golino Jihye L. , Bian Jing , Wang Xin , Fu Jianyang , Zhu Xiao Bin , Yeo Julie , Kelly Michael , Escorcia Freddy E. , Cam Maggie , Xie Changqing
Published: November 2023

Cholangiocarcinoma is a malignancy of the bile ducts that is driven by activities of cancer stem-like cells and characterized by a heterogeneous tumor microenvironment. To better understand the transcriptional profiles of cancer stem-like cells and dynamics in the tumor microenvironment during the progression of cholangiocarcinoma, we performed single-cell RNA analysis on cells collected from three different timepoints of tumorigenesis in a YAP/AKT mouse model. Bulk RNA sequencing data from TCGA (The Cancer Genome Atlas program) and ICGC cohorts were used to verify and support the finding. In vitro and in vivo experiments were performed to assess the stemness of cancer stem-like cells. We identified Tm4sf1high malignant cells as cancer stem-like cells. Across timepoints of cholangiocarcinoma formation in YAP/AKT mice, we found dynamic change in cancer stem-like cell/stromal/immune cell composition. Nevertheless, the dynamic interaction among cancer stem-like cells, immune cells, and stromal cells at different timepoints was elaborated. Collectively, these data serve as a useful resource for better understanding cancer stem-like cell and malignant cell heterogeneity, stromal cell remodeling, and immune cell reprogramming. It also sheds new light on transcriptomic dynamics during cholangiocarcinoma progression at single-cell resolution.
Coevolutionary dynamics of group interactions: coevolving nonlinear voter models
Authors: Min Byungjoon
Published: November 2023

We survey the coevolutionary dynamics of network topology and group interactions in opinion formation, grounded on a coevolving nonlinear voter model. The coevolving nonlinear voter model incorporates two mechanisms: group interactions implemented through nonlinearity in the voter model and network plasticity demonstrated as the rewiring of links to remove connections between nodes in different opinions. We show that the role of group interactions, implemented by the nonlinearity can significantly impact both the dynamical outcomes of nodes’ state and the network topology. Additionally, we review several variants of the coevolving nonlinear voter model considering different rewiring mechanisms, noise of flipping nodes’ state, and multilayer structures. We portray the various aspects of the coevolving nonlinear voter model as an example of network coevolution driven by group interactions, and finally, present the implications and potential directions for future research.
Time and day: trends in student access to online asynchronous courses in communication demonstrate time poverty in action
Authors: LeBlanc H. Paul
Published: November 2023

Objective

As changes to higher education following the rapid transition to online learning resulting from the COVID-19 pandemic impacted students and their perceptions of what is possible in scheduling their daily lives around school, this study investigates trends in student access to online asynchronous courses.

Methods

This study utilized course reports of student access from the learning management system for thirty-one sections of eleven different online asynchronous communication courses taught by ten different faculty members over the fall and spring semesters at a large research university in the southwestern United States. A total sample size of 1,201 students were involved in the study.

Results

Profile Analyses indicate clear curvilinear trends for time of day and day of the week in student course access. Repeated Measures ANOVA results indicate those trends vary significantly from a no effect condition, suggesting that students: (a) schedule their course activities around personal schedules, and (b) that time bound synchronous course may not work for them.

Conclusion

Recommendations for class management by instructors relating to student time poverty need regardless of teaching modality, and future directions for research on time poverty in higher education, are provided.
Nursing students bringing first aid to the community
Authors: Ramírez-Torres Carmen Amaia , Andrade-Gómez Elena , Lozano-Ochoa Cristina , Caparrós-Civera María Neus , Sapiña-Beltrán Esther
Published: November 2023

Aim

This study aimed to evaluate the theoretical and practical skills acquired by nursing students and school students after the service-learning project.

Methods

This study promotes nursing students and school students working together to gain awareness and basic theoretical knowledge of first aid. The learning project was conducted with nursing students (n = 67) and school students (n = 131) from April to June 2022. The nursing students gave scores higher than 8 on the aspects linked to expectations, self-perception, overall assessment, and attainment of the goals, and these results are in line with the qualitative analysis.

Results

Moreover, 100% of the school students reported a satisfactory outcome about the service.

Conclusion

Service-learning is a challenging and motivating methodology for nursing students, which results in greater engagement with theory and practice and the development of essential skills for future professionals.
Case Report: A combination of chimeric CYP11B2/CYP11B1 and a novel p.Val68Gly CYP11B1 variant causing 11β-Hydroxylase deficiency in a Chinese patient
Authors: Li Jialin , Zhang Fenglan , Xu Miao , Qiu Hao , Zhou Cheng , Li Li , Qin Lan
Published: November 2023

Introduction

11β-Hydroxylase deficiency (11β-OHD, OMIM#202010) is the second most common form of congenital adrenal hyperplasia (CAH) caused by pathogenic variants in the CYP11B1 gene. Both single nucleotide variations (SNV)/small insertion and deletion and genomic rearrangements of CYP11B1 are important causes of 11β-OHD. Among these variant types, pathogenic CYP11B2/CYP11B1 chimeras only contribute to a minority of cases. Heterozygote cases (chimera combined with SNV) are very rare, and genetic analysis of these cases can be challenging.

Case presentation

We presented a suspected 11β-OHD female patient with incomplete virilization, adrenal hyperplasia, and hypokalemia hypertension. Whole exome sequencing (WES) revealed that the patient carried both a chimeric CYP11B2/CYP11B1 and a novel missense variant, NM_000497.4: c.203T>G, p.Val68Gly (chr8:143961027) in CYP11B1, which were confirmed by CNVplex and Sanger sequencing, respectively. The patient’s manifestations and genetic findings confirmed the diagnosis of 11β-OHD, and oral dexamethasone was administered as a subsequent treatment.

Conclusion

This report showed a rare CYP11B2/CYP11B1 chimera combined with a novel missense variant in a 11β-OHD female patient. The result expands variant spectrum of CYP11B1 and suggests that both chimera and CYP11B1 variant screening should be performed simultaneously in suspected cases of 11β-OHD. To our knowledge, this is the first report about CYP11B2/CYP11B1 chimera detected by WES analysis. WES combined with CNV analysis is an efficient method in the genetic diagnosis of this rare and complex disorder.
The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern
Authors: Sun Wen-Jie , An Xue-Dong , Zhang Yue-Hong , Zhao Xue-Fei , Sun Yu-Ting , Yang Cun-Qing , Kang Xiao-Min , Jiang Lin-Lin , Ji Hang-Yu , Lian Feng-Mei
Published: November 2023

Diabetic retinopathy (DR) is a prevalent complication of diabetes, significantly impacting patients’ quality of life due to vision loss. No pharmacological therapies are currently approved for DR, excepted the drugs to treat diabetic macular edema such as the anti-VEGF agents or steroids administered by intraocular route. Advancements in research have highlighted the crucial role of early intervention in DR for halting or delaying disease progression. This holds immense significance in enhancing patients’ quality of life and alleviating the societal burden associated with medical care costs. The non-proliferative stage represents the early phase of DR. In comparison to the proliferative stage, pathological changes primarily manifest as microangiomas and hemorrhages, while at the cellular level, there is a loss of pericytes, neuronal cell death, and disruption of components and functionality within the retinal neuronal vascular unit encompassing pericytes and neurons. Both neurodegenerative and microvascular abnormalities manifest in the early stages of DR. Therefore, our focus lies on the non-proliferative stage of DR and we have initially summarized the mechanisms involved in its development, including pathways such as polyols, that revolve around the pathological changes occurring during this early stage. We also integrate cutting-edge mechanisms, including leukocyte adhesion, neutrophil extracellular traps, multiple RNA regulation, microorganisms, cell death (ferroptosis and pyroptosis), and other related mechanisms. The current status of drug therapy for early-stage DR is also discussed to provide insights for the development of pharmaceutical interventions targeting the early treatment of DR.
A novel automatic generation control method with hybrid sampling for multi-area interconnected girds
Authors: Zhang Shengxi , Lan Feng , Xue Binglei , Chen Qingwei , Qiu Xuanyu
Published: November 2023

Introduction: The emerging “net-zero carbon” police will accelerate the large-scale penetration of renewable energies in the power grid, which would bring strong random disturbances due to the unpredictable power output. It would affect the coordinated control performance of the distributed grids.

Method: From the quadratic frequency modulation perspective, this paper proposes a fast Q-learning-based automatic generation control (AGC) algorithm, which combines full sampling with full expectation for multi-area coordination. A parameter σ is used to balance the state between the full sampling update and only the expectation update so as to improve the convergence accuracy. Meanwhile, fast Q-learning is incorporated by replacing the historical estimation function with the current state estimation function to accelerate the convergence speed.

Results: Simulations on the IEEE two-region load frequency control model and Hubei power grid model in China have been performed to validate that the proposed algorithm can achieve optimal multi-area coordination and improve the control performance of frequency deviations caused by the strong random disturbances.

Discussion: The proposed Q-learning-based AGC method outperforms the convergence accuracy, speed, and control performance compared with other reinforcement learning algorithms.
Hybrid bilevel optimization-based interaction between the distribution grid and PV microgrids with differentiated demand response
Authors: Shao Zhimin , Liu Chunxiu , Yao Rui , Wang Cong , Li Longtan , Liu Zhen , Liu Yimin , Zhou Zaiyan
Published: November 2023

Demand response plays an important role in improving the balance of power generation and consumption between the distribution grid and photovoltaic (PV) microgrids. However, due to the uncertainty and volatility of PV output, as well as the different operation goals of PV microgrids, a conventional single-tier optimization approach is infeasible to realize the coordinated interaction between the distribution grid and PV microgrids. To address these challenges, we propose a second-order cone and improved consensus algorithm-based hybrid bilevel optimization algorithm for the interaction between the distribution grid and PV microgrids. First, we construct price-based and incentive-based differentiated demand response models to deal with various supply and demand dynamics of the distribution grid and PV microgrids. Building upon this foundation, we construct a hybrid bilevel optimization model. In the lower level, distributed optimization is adopted, and an improved consensus algorithm is used to optimize power output of PV microgrids to maximize the revenue based on output power of upper-level generator sets. In the upper level, centralized optimization is adopted, and second-order cone programming is employed to minimize the grid loss in the distribution grid based on the power output of lower-level PV microgrids. Hybrid bilevel optimization is iterated until the convergence condition is satisfied. Simulation results verify the proposed algorithm for achieving a coordinated interaction between the distribution grid and PV microgrids.
Road performance evaluation of prestressed high-strength concrete pile waste powder as alternative filler in asphalt concrete
Authors: Tu Botao , Yang Xinkui , Xu Shi , Zhao Zenggang , Zhou Yuheng , Jiang Jian , Fan Lulu , Tu Liangliang
Published: November 2023

As a kind of solid waste, using Prestressed High-Strength Concrete Pile Waste Concrete (PPWC) as the replacement for limestone filler in asphalt concrete can not only reduce the accumulation of PPWC and increase its utilization but also avoid the increased road construction costs and environmental degradation associated with limestone mining. This study aims to investigate the effect of using PPWC filler to replace limestone filler on the road performance of asphalt concrete. Firstly, PPWC was ground into filler particles with a diameter less than 0.075 mm. The particle characteristics such as surface morphology, particle size distribution and chemical composition of PPWC filler and limestone filler were compared. Then, PPWC filler was used to replace limestone filler with different volume fractions to prepare asphalt concrete, and the water damage resistance, high-temperature rutting resistance, low-temperature crack resistance, fatigue resistance and adhesion performance of asphalt concrete were tested. The results showed that PPWC filler has a smaller particle size and rougher surface than limestone filler, and it contains Ca(OH)2 produced by hydration. The addition of PPWC filler can effectively improve the mechanical properties of asphalt concrete without reducing its water damage resistance. PPWC filler can improve the high-temperature rutting resistance and low-temperature crack resistance of asphalt concrete, but reduce its low-temperature fatigue resistance. The low content of PPWC filler will enhance the adhesion between asphalt mortar and aggregate. However, when the content of PPWC filler exceeds 50%, Ca (OH)2 in PPWC will reduce the adhesion between acid asphalt mortar and alkaline basalt aggregate. Therefore, the use of PPWC as filler in asphalt mixtures provides a reliable solution for the sustainable development of road materials.
Deciphering the formation period and geological implications of shale tectonic fractures: a mini review and forward-looking perspectives
Authors: Li Hu
Published: November 2023

In complex geological areas, the chronology of tectonic fracture formation is pivotal for the conservation and enhancement of shale gas reservoirs. These fractures, evolving over different geologic epochs, critically influence the modifications in hydraulic fracturing. The review sheds light on an integrated methodology that bridges conventional geological evaluations with experimental diagnostics to decipher the intricate evolution of such fractures in complex geological areas. Shale tectonic fractures, predominantly shear-induced, are delineated into four distinct levels (I, II, III, IV) based on observational scales. Understanding the geometric interplay across these scales provides insight into fracture distribution. Recognizing the constraints of isolated approaches, this study amalgamates macroscopic geological assessments, such as structural evolution and fault analysis, with microscopic techniques, including fluid inclusion studies, isotopic testing, rock AE experiments (U-Th)/He thermochronology, and AFT analysis, etc. This combined approach aids in accurately determining the tectonic fracture’s genesis and its geological time. Future research endeavors should refine this framework, with an emphasis on enhanced geochemical profiling of fracture fillings.
Government environmental information disclosure and corporate carbon performance
Authors: Peng Manru , Peng Shichun , Jin Youliang , Wang Shujuan
Published: November 2023

Environmental problem is the key to the healthy development of China’s eco-economy, and the environmental responsibility of micro-enterprises under the vision of “Dual Carbon” has attracted more attention. Under the effect of formal environmental regulation, firms will improve their environmental performance by improving technology and resource utilization. As an informal environmental system, can government environmental information disclosure (GEID) guide firms to actively carry out green innovation, ultimately improve the carbon emission problem of firms, have a positive impact on the carbon performance of enterprises, and provide strong support to protect ecological environment? To address this question, this study used the Pollution Information Transparency Index (PITI) to measure GEID, and empirically tested the impact of GEID on corporate carbon performance using a sample of listed companies involved in China’s mining and manufacturing industries from 2013 to 2018. The study found that the higher the degree of GEID, the better was the corporate carbon performance. However, the improved public participation weakened the effect of GEID on corporate carbon performance. GEID reduced the carbon emission intensity of firms and improved their carbon performance via green innovation. Further research indicated that the enhanced GEID in state-owned enterprises significantly improved carbon performance of firms. This study provides empirical evidence for GEID to improve corporate carbon performance, and also proposes a policy strategy for the government to guide firms to undertake green innovation and promote firms to improve efficient carbon use.
137Cs inventories in soil in the Qaidam Basin, Tibetan Plateau
Authors: Bian Kai , Wang Cuiping , Shen Yulong
Published: November 2023

This paper presents measurements of cesium-137 (137Cs) in the Qaidam Basin during 2019 with 39 soil samples across the landscape. The aim here is to use the results of 137Cs inventories for the Qaidam Basin to subsequently estimate soil wind erosion. The 137Cs inventories in the surface soil vary from lower limit detection (LDD) to 1,072 Bq m−2, with a mean of 266 Bq m−2. Overall, the 137Cs inventories in the Qaidam Basin decreases from southeast to northwest. The highest 137Cs inventories was found in farmland, and the lowest was found in Gobi. Wetlands had higher 137Cs inventories than their neighboring sites.
Filling out the gaps – identification of fugralins as products of the PKS2 cluster in Fusarium graminearum
Authors: Severinsen Manja Mølgaard , Westphal Klaus Ringsborg , Terp Mikael , Sørensen Trine , Olsen Anders , Bachleitner Simone , Studt-Reinhold Lena , Wimmer Reinhard , Sondergaard Teis Esben , Sørensen Jens Laurids
Published: November 2023

As one of the grain crop pathogenic fungi with the greatest impacts on agricultural economical as well as human health, an elaborate understanding of the life cycle and subsequent metabolome of Fusarium graminearum is of great interest. Throughout the lifetime of the fungus, it is known to produce a wide array of secondary metabolites, including polyketides. One of the F. graminearum polyketides which has remained a mystery until now has been elucidated in this work. Previously, it was suggested that the biosynthetic product of the PKS2 gene cluster was involved in active mycelial growth, the exact mechanism, however, remained unclear. In our work, disruption and overexpression of the PKS2 gene in F. graminearum enabled structural elucidation of a linear and a cyclic tetraketide with a double methyl group, named fugralin A and B, respectively. Further functional characterization showed that the compounds are not produced during infection, and that deletion and overexpression did not affect pathogenicity or visual growth. The compounds were shown to be volatile, which could point to possible functions that can be investigated further in future studies.
Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators
Authors: Kumar Rupesh , Madhavan Thirumurthy , Ponnusamy Kalaiarasan , Sohn Honglae , Haider Shazia
Published: November 2023

Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a distinguishing feature in several neurodegenerative disorders, including hereditary spastic paraplegia (HSP10), Charcot-Marie-Tooth disease type 2 (CMT2), and Amyotrophic Lateral Sclerosis (ALS).

Methods: In this study, we implemented a computational structural and systems biology approach to uncover the role of KIF5A in ALS. Using the computational structural biology method, we explored the role of non-synonymous Single Nucleotide Polymorphism (nsSNPs) in KIF5A. Further, to identify the potential inhibitory molecule against the highly destabilizing structure variant, we docked 24 plant-derived phytochemicals involved in ALS.

Results: We found KIF5AS291F variant showed the most structure destabilizing behavior and the phytocompound “epigallocatechin gallate” showed the highest binding affinity (−9.0 Kcal/mol) as compared to wild KIF5A (−8.4 Kcal/mol). Further, with the systems biology approach, we constructed the KIF5A protein-protein interaction (PPI) network to identify the associated Kinesin Families (KIFs) proteins, modules, and their function. We also constructed a transcriptional and post-transcriptional regulatory network of KIF5A. With the network topological parameters of PPIN (Degree, Bottleneck, Closeness, and MNC) using CytoHubba and computational knock-out experiment using Network Analyzer, we found KIF1A, 5B, and 5C were the significant proteins. The functional modules were highly enriched with microtubule motor activity, chemical synaptic transmission in neurons, GTP binding, and GABA receptor activity. In regulatory network analysis, we found KIF5A post-transcriptionally down-regulated by miR-107 which is further transcriptionally up-regulated by four TFs (HIF1A, PPARA, SREBF1, and TP53) and down-regulated by three TFs (ZEB1, ZEB2, and LIN28A).

Discussion: We concluded our study by finding a crucial variant of KIF5A and its potential therapeutic target (epigallocatechin gallate) and KIF5A associated significant genes with important regulators which could decrypt the novel therapeutics in ALS and other neurodegenerative diseases.
B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients
Authors: Vietsch Eveline E. , Latifi Diba , Verheij Maaike , van der Oost Elise W.A. , de Wilde Roeland F. , Haen Roel , van den Boom Anne Loes , Koerkamp Bas Groot , Doornebosch Pascal G. , van Verschuer Victorien M.T. , Ooms Ariadne H.A.G. , Mohammad Farzana , Willemsen Marcella , Aerts Joachim G.J.V. , Krog Ricki T. , de Miranda Noel F.C.C. , van den Bosch Thierry P.P. , Mueller Yvonne M. , Katsikis Peter D. , van Eijck Casper H.J.
Published: November 2023

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid tumors and is resistant to immunotherapy. B cells play an essential role in PDAC progression and immune responses, both locally and systemically. Moreover, increasing evidence suggests that microbial compositions inside the tumor, as well as in the oral cavity and the gut, are important factors in shaping the PDAC immune landscape. However, the gut-associated lymphoid tissue (GALT) has not previously been explored in PDAC patients. In this study, we analyzed healthy vermiform appendix (VA) from 20 patients with PDAC and 32 patients with colon diseases by gene expression immune profiling, flow cytometry analysis, and microbiome sequencing. We show that the VA GALT of PDAC patients exhibits markers of increased inflammation and cytotoxic cell activity. In contrast, B cell function is decreased in PDAC VA GALT based on gene expression profiling; B cells express significantly fewer MHC class II surface receptors, whereas plasma cells express the immune checkpoint molecule HLA-G. Additionally, the vermiform appendix microbiome of PDAC patients is enriched with Klebsiella pneumoniae, Bifidobacterium animalis, and Adlercreutzia equolifaciens, while certain commensals are depleted. Our findings may suggest impaired B cell function within the GALT of PDAC patients, which could potentially be linked to microbial dysbiosis. Additional investigations are imperative to validate our observations and explore these potential targets of future therapies.