bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel mutation in SORD gene associated with Distal Hereditary Motor Neuropathies
Authors: Yuan Xiaoqin , Zhang Shanshan , Shang Huifang , Tang Yufeng
Published: October 2023

Background
Distal hereditary motor neuropathy (dHMN) is a heterogeneous group of hereditary diseases caused by the gradual degeneration of the lower motor neuron. More than 30 genes associated with dHMN have been reported, while 70–80% of those with the condition are still unable to receive a genetic diagnosis.
Methods
A 26-year-old man experiencing gradual weakness in his lower limbs was referred to our hospital, and data on clinical features, laboratory tests, and electrophysiological tests were collected. To identify the disease-causing mutation, we conducted whole exome sequencing (WES) and then validated it through Sanger sequencing for the proband and his parents. Silico analysis was performed to predict the pathogenesis of the identified mutations. A literature review of all reported mutations of the related gene for the disease was performed.
Results
The patient presented with dHMN phenotype harboring a novel homozygous variant c.361G > C (p.Ala121Pro) in SORD, inherited from his parents, respectively. A121 is a highly conserved site and A121P is predicted to disrupt its normal splicing. A total of 13 published articles including 101 patients reported 18 SORD variants. Almost all described cases have the homozygous deletion variant c.757delG (p.A253Qfs*27) or compound heterozygous state of a combination of c.757delG (p.A253Qfs*27) with another variant. The variant c.361G > C (p.Ala121Pro) detected in our patient was the second homozygous variant in SORD-associated hereditary neuropathy.
Conclusion
One novel homozygous variant c.361G > C (p.Ala121Pro) in SORD was identified in a Chinese patient with dHMN phenotype, which expands the mutation spectrum of SORD-associated hereditary neuropathy and underscores the significance of screening for SORD variants in patients with undiagnosed hereditary neuropathy patients.
Machine learning can reliably predict malignancy of breast lesions based on clinical and ultrasonographic features.
Authors: Buzatto Isabela Carlotti , Recife Sarah Abud , Miguel Licerio , Onari Nilton , Faim Ana Luiza Peloso , Bonini Ruth Morais , Silvestre Liliane , Carlotti Danilo Panzeri , Fröhlich Alek , Tiezzi Daniel Guimarães
Published: October 2023

Purpose
To establish a reliable machine learning model to predict malignancy in breast lesions identified by ultrasound and optimize the negative predictive value to minimize unnecessary biopsies.
Methods
We included clinical and ultrasonographic attributes from 1526 breast lesions classified as BI-RADS 3, 4a, 4b, 4c, 5 and 6 that underwent ultrasound guided breast biopsy in four institutions. We selected the most informative attributes to train nine machine learning models, ensemble models and models with tuned threshold to make inferences about the diagnosis of BI-RADS 4a and 4b lesions (validation dataset). We tested the performance of the final model with 403 new suspicious lesions.
Results
The most informative attributes were shape, margin, orientation and size of the lesions, the resistance index of the internal vessel, the age of the patient and the presence of a palpable lump. The highest mean NPV was achieved with KNN (97.9%). Making ensembles didn´t improve the performance. Tuning the threshold did improve the performance of the models and we chose the XGBoost with the tuned threshold as the final one. The tested performance of the final model was: NPV 98.1%, FN 1.9%, VPP 77.1%, FP 22.9%. Applying this final model, we would have missed 2 of the 231 malignant lesions of the test dataset (0.8%).
Conclusion
Machine learning can help physicians predict malignancy in suspicious breast lesions identified by the US. Our final model would be able to avoid 60.4% of the biopsies in benign lesions missing less than 1% of the cancer cases.
A new method for intuitionistic fuzzy multi-objective linear programming based on fuzzy reasoning GA
Authors: Esmaeili Mahin , Jafarpour Morteza , Shahsavari-Pour Nasser
Published: October 2023

‎An attempt is made to propose a new method for the intuitionistic fuzzy multi-objective linear programming (IFMOLP) problems by applying the intuitionistic fuzzy (IF) coefficients and IF inequality relations‎. ‎The IFMOLP problem is considered a rule-based system where optimizing the similarity of the truth table method is applied in intuitionistic fuzzy reasoning. A customized GA is proposed to solve this problem‎. Examples are presented to confirm the efficiency of this newly proposed method‎, vs. its counterparts in this context.
Associations between domains of sedentary behavior, well-being, and quality of life – A cross-sectional study
Authors: Teno Sabrina C , Silva Marlene N , Júdice Pedro B.
Published: October 2023

Background
The importance of reducing sedentary behavior (SB) in the prevention of mortality and chronic and mental diseases is scientifically well grounded, but SB can be accumulated in diverse domains of life, such as leisure-time SB, transport between home/work/school when sitting (transport-related SB), or in occupational settings such as working or studying (occupational SB), and the associations for each domain of SB with well-being measures and quality of life are still underexplored from a positive perspective.
Methods
Through a cross-sectional investigation, we collected data from 584 participants who completed a questionnaire throughout November 2021 and with Spearman correlation test, analysed the associations between SB in three different domains with psychological well-being, satisfaction with life, and quality of life.
Results
Our results indicated that after adjustment for physical activity, sex, body mass index, smoking history, chronic disease status, financial perception, quality, and duration of sleep, in younger adults (18 to 24 years old), leisure-time SB was negatively related to psychological well-being (rho = -0.254; p = 0.008), and in adults (25 to 64 years old), occupational SB was negatively related to satisfaction with life (rho = -0.255; p < .001) and the mental component of quality of life (rho = -0.174; p = 0.018).
Conclusions
Our findings highlight the idea that not all SB is built the same and that future strategies to reduce SB from people’s lives must target specific domains of SB according to the age group when aiming to improve well-being and quality of life.
Robotic-assisted, pancreatectomy for a pancreatic neoplasms in a pediatric patient: initial experience case series and review of the literature
Authors: Yang Jiafei , Gu Huajian , Du Jun , Xu Zhongmin , Sun Xu , He Kunfeng
Published: October 2023

Objective: To present our primary experience of robotic-assisted pancreatectomy for pancreatic neoplasms in children.
Methods: From June 2021 to January 2023, We conducted a retrospective review of 4 patients with pancreatic neoplasms who underwent Da Vinci robotic pancreatic surgery, who underwent Da Vinci robot-assisted enucleation of the pancreatic tumor, pancreic-distal preserving pancreatectomy and Distal pancreatectomy tumor and Splenectomy, respectively. The surgical methods, operation time, intraoperative blood loss, postoperative hospital stay and complications were analyzed. Characteristics and outcome of patients were compared with results of a systematic Pubmed and Medline.
Result: None of the 4 patients was converted into laparotomy or had intraoperative blood transfusion. The operation time was 175 ~ 395 min, intraoperative blood loss was 15 ~ 120 ml, and postoperative hospital stay was 6-10 d. No postoperative complications occurred. The patients were followed up for 6-12 months, without tumor recurrence. Through the literature search, a total of 8 cases were included in this study. The operation time was 65 ~ 480 min, intraoperative blood loss was 5 ~ 10 ml, and postoperative hospital stay was 6-16 d. Two of these children developed delayed gastric emptying and Ileus and an episode of post-operative vomiting, respectively.
Conclusions: Our experience continues to evolve, and suggests that robotic surgery is safe, feasible and effective for resection of pancreatic neoplasms in pediatric patients.
Sex differences in disease burden, utilization, and expenditure on Primary Health Care Services: Findings from a baseline study in Kerala, India
Authors: Joseph Jaison , Sankar Hari , Sharma Santosh Kumar , Nambiar Devaki
Published: October 2023

We conducted a cross-sectional study to explore the nature and magnitude of sex differences in disease burden, service awareness, utilization, expenditure and satisfaction while accessing primary health care services in light of recent primary care reforms implemented in Kerala. More males reported fever as their primary ailment compared to females (67.7% vs. 58.6%). A greater proportion of males as compared to females knew about the recently implemented reforms (43% vs 36%; p = 0.01). Allopathic care was the most sought-after system of medicine by both sexes. A higher proportion of females visited government primary health centres for outpatient care (34.7% vs. 27.5%; p = 0.00). The self reported cost of care in the private sector was 20 times greater than in public sector for males, whereas the difference was roughly five fold among females (Private: ₹650, $8.5 (95% CI- ₹524, ₹776) vs. Public: ₹120, $1.58 (95%CI- ₹17, ₹223)). Our population-based study found no sex- differences in non-hospitalized disease burden. Males showed greater awareness of state health reforms, and high patient satisfaction existed in both private and public OP care. Research on intersectionalities, such as care-seeking experiences across genders and socioeconomic groups, could enhance our understanding of sex's role in care seeking. Sex differences in disease burden, utilization, and expenditure of Primary Health Care services: Findings from a baseline study in Kerala, India
Farnesyl Diphosphate Synthase (FDPS) Regulates Granulosa Cells Proliferation of Polycystic Ovary Syndrome (PCOS) by Modulating the Rac1/MAPK/ERK signaling
Authors: Guo Xiaoli , Cao Yijuan , He Qing , Chen Linna , Wang Qing , Zhang Jingbo , Lv Wenqiang , Zhang Bei , Zhou Xueyan
Published: October 2023

Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in child-bearing-age women. Due to a poor understanding of the mechanisms involved, there is a limited selection of etiology-specific treatments for infertility in individuals with PCOS. Here, proteomic analysis indicated that the differential protein ovarian Farnesyl Diphosphate Synthase (FDPS) was closely related to the pathogenesis of PCOS. Notably, FDPS protein expression was significantly decreased in ovarian granulosa cells from PCOS patients resulted in disrupted ovarian functions and dysplasia of ovarian granulosa cells. The mechanisms by which FDPS affected the proliferation of granulosa cells were also explored both in vitro and in vivo. We found that knockdown of FDPS inhibited the proliferation of KGN (human ovarian granulosa cell line), while overexpression of FDPS had the opposite effect. FDPS activated Rac1 activity and regulated MAPK/ERK signaling pathway, which affecting the proliferation of KGN cells significantly. In addition, treatment with the Adeno-Associated Virus (AAV)-FDPS reverse the DHEA-induced PCOS-phenotype in mice. Our data indicated that FDPS could regulate the proliferation of ovarian GCs by modulating MAPK/ERK pathway via activating Rac1 activity. These findings suggest that FDPS could be of great value for the regulation of ovarian granulosa cell function and the treatment of PCOS.
An implicit measure of growth mindset uniquely predicts post-failure learning behavior
Authors: Sik Kata , Cummins Jamie , Job Veronika
Published: October 2023

Research on implicit theories of intelligence (a.k.a. intelligence mindset) has shown that a growth mindset (the belief that intelligence can be improved) is adaptive in the face of challenges and setbacks. Even though the theory presumes implicit processes (i.e., people are supposed to be unaware of these beliefs, guiding behaviors and actions automatically), the concept is typically assessed with self-reports. In this project we brought together research on intelligence mindset with research on implicit social cognition. Harnessing recent innovations from research on implicit measures, we assessed intelligence mindsets on an implicit level with a mousetracking Propositional Evaluation Paradigm. This measure captures the spontaneous truth evaluation of growth- and fixed-mindset statements to tap into implicit beliefs. In two preregistered laboratory studies (N = 184; N = 193), we found that implicitly measured growth mindsets predicted learning engagement after an experience of failure above and beyond the explicitly measured growth mindset. Our results suggest that implicit and explicit aspects of intelligence mindsets must be differentiated. People might be in a different mindset when making learning-related decisions under optimal conditions (i.e., with ample time and capacity) or under suboptimal conditions (i.e., when time pressure is high). This advancement in the understanding of implicit theories of intelligence is accompanied with substantial implications for theory and practice.
Validity of Self-Assessed Oral Health in Japanese Workers
Authors: Zaitsu Takashi , Saito Tomoya , Oshiro Akiko , Kawaguchi Yoko , Kawachi Ichiro
Published: October 2023

Background
We sought to establish the validity of self-reported oral health by comparison with the results of clinical dental examinations. A secondary aim was to explore the association of self-rated oral health with oral health behaviors.
Materials and methods
Self-administered questionnaires and dental examinations were obtained from 2,262Japanese private sector employees. Workers self-assessed their overall oral health status according to five choices: “very good,” “good,” “fair,” “poor,” or “bad.” Self-reports were then compared with the results of clinical dental examination which included measuring the oral hygiene index (DI-S), the number of decayed teeth, periodontal status (Community Periodontal Index) and number of missing teeth. Convergent validity was also tested by examining the correlations of self-reported oral health status with oral health behaviors.
Results
Overall, 30.8% of workers reported their oral health as “poor” or “bad.” “Poor” or “bad” oral health status was significantly correlated with missing teeth, periodontitis, and decayed teeth. However, lower correlations were found for gingivitis and the oral hygiene index. Most self-reported oral health behaviors were correlated with self-rated oral health; exceptions were “tooth brushing instructions received in a dental clinic,” “having a primary-care dentist,” and “habitual snacking between meals.”
Conclusions
Self-rated oral health provides reasonably valid data, and correlated well with clinically assessed oral health status, including dental caries, periodontal status, and tooth loss. Convergent validity was also found for oral health behaviors.
Clinical Trial Registration Number:
UMIN000023011 (UMIN-CTR)
Date of clinical trial registration: 06/07/2016
Homogenised Elastic Properties of Lightweight Cemented Soils
Authors: Perrotta Laura , Vitale Enza , Russo Giacomo
Published: October 2023

Lightweight Cemented Soil (LWCS) is obtained by mixing soil, water and cement with air foam. This treatment allows a high workability of the mixture and good mechanical properties coupled with reduced unit volume weight, making the material suitable for many geotechnical applications. The complex and heterogeneous microstructure (a large pore system induced by foam in a cemented porous matrix) of the material requires a homogeneisation procedure for constitutive modelling of its hydromechanical behaviour. In this work, the stiffness modulus of LWCS was derived through the semi-analitycal Mean-Field Eshelby-based Homogenisation approaches, taking into account the chemo-physical evolution over curing time of the material. This procedure, never employed in the field of treated soils, requires several input parameters, as the artificial porosity induced by the addition of foam, the bulk and shear moduli and the Poisson’s ratio of LWCS samples. The artificial porosity was evaluated by means of X-Ray micro-CT scans, whereas the mechanical parameters were derived from experimental tests. The homogenised stiffness moduli, computed for different curing times, are in agreement with the available experimental results. The analytical homogenisation models allow predicting the elastic behaviour of the material and its evolution over time taking into account the role played by microstructure.
Systemic Effects of Hypophosphatasia. Characterization of Two Novel Variants in the Alpl Gene
Authors: Fontana Cristina , Heredia Luis , Muñoz-Torres Manuel , Torre Raquel de la , Ortas Angela , Vera Francisco , Cejudo Trinidad , Bolívar Victoria , Salvatierra Sheila , Gómez-Vida José , Fontana Beatriz
Published: October 2023

Hypophosphatasia (HPP) is a metabolic inborn error caused by mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSALP) leading to a decreased alkaline phosphatase (ALP) activity. Although the main hallmark of this disease is bone involvement it presents great genetic and clinical variability, which is regarded as it a systemic disease. In the present study, two previously undescribed heterozygous mutations (L6S and T167del) have been identified by Sanger sequencing in the ALPL gene of two Spanish families. These mutations are associated with non-pathognomonic symptoms of HPP. Prediction tools coupled with structural modeling targeted critical residues with important roles in protein structure and function. In vitro results demonstrated low TNSALP activity and a dominant negative effect on both mutations. The results of the characterization of these variants suggest that the pleiotropic role of TNSALP leads to the systemic effects observed in these patients highlighting digestive and autoimmune disorders associated with TNSALP dysfunction. The importance of identifying and geno-phenotypically characterizing each mutation at structural and functional levels is very useful to anticipate potential comorbidities, providing personalized counseling and treatment for each patient considering the extra-skeletal manifestations of HPP.
Dynamic Impacts of Weather Alteration and Urbanization on Entomofauna Diversity in Urban Ecosystem: A Study in the Rohtak District at Tilyar Lake and Maharshi Dayanand University
Authors: Kumari Tamanna , Phogat Deepak , Phogat Jatin , Sonam Sonam , Shukla Vineeta
Published: October 2023

Climate change and urbanization are resulting in notable transformations to ecosystems, altering species distributions and interactions within food webs. This study utilized specific insect collection methods (pitfall traps, bottle traps, pan traps, double-sided tape) and identification techniques (citizen science, automated insect identification, field guides, mobile applications, dichotomous keys) to gather data on entomofauna diversity under varying weather conditions in urban areas (Maharshi Dayanand University, Rohtak, and Tilyar Lake). By combining these approaches, a comprehensive assessment of insect diversity across different weather conditions was achieved. The impacts of weather and urbanization on entomofauna diversity are significant. Within the studied area, 73 insect species were documented in total, with the highest diversity consistently observed in spring. Summer exhibited the next highest diversity levels, while winter displayed comparatively lower diversity. These findings highlight the pronounced influence of seasonal variations and urbanization on the composition and abundance of insect populations. The results provide compelling evidence that both weather change and urbanization play major roles in shaping local insect diversity. These conclusions were further reinforced through calculations of relative diversity.
Assessment of Atherosclerotic Plaque Burden: Comparison of AI-QCT versus SIS, CAC, Visual and CAD-RADS Stenosis Categories
Authors: Khan Hufsa , Bansal Kopal , Griffin William F. , Cantlay Catherine , Sidahmed Alfateh , Nurmohamed Nick , Zeman Robert K. , Katz Richard J. , Blankstein Ron , Earls James P. , Choi Andrew D.
Published: October 2023

Purpose: This study assesses the agreement of Atherosclerosis Imaging-Quantitative Computed Tomography (AI-QCT) with qualitative approaches to atherosclerotic disease burden codified in the multisociety 2022 CAD-RADS 2.0 Expert Consensus.
Methods: 105 patients who underwent cardiac computed tomography angiography (CCTA) for chest pain were evaluated by a blinded core laboratory through FDA-cleared software (Cleerly, Denver, CO) that performs AI-QCT through artificial intelligence, analyzing factors such as % stenosis, plaque volume, and plaque composition. AI-QCT plaque volume was then staged by recently validated prognostic thresholds, and compared with CAD-RADS 2.0 clinical methods of plaque evaluation (segment involvement score (SIS), coronary artery calcium score (CACS), visual assessment, and CAD-RADS percent (%) stenosis) by expert consensus blinded to the AI-QCT core lab reads.
Results: Average age of subjects were 59 ± 11 years; 44% women, with 50% of patients at CAD-RADS 1-2 and 21% at CAD-RADS 3 and above by expert consensus. AI-QCT quantitative plaque burden staging had excellent agreement of 93% (k=0.87 95% CI: 0.79-0.96) with SIS. There was moderate agreement between AI-QCT quantitative plaque volume and categories of visual assessment (64.4%; k=0.488 [0.38-0.60]), CACS (66.3%; k=0.488 [0.36-0.61]). Agreement between AI-QCT plaque volume stage and CAD-RADS % stenosis category was also modest. (73.1%; k=0.55 [0.42-0.68]).
Conclusion: AI-QCT graded plaque volume stages and SIS demonstrated overall high agreement while agreement of AI-QCT with visual estimate and CACS was moderate. In addition, AI-QCT graded stenosis CAD-RADS was moderate to substantial. There was discordance at small plaque volumes. With ongoing validation, these results demonstrate a potential for AI-QCT as a rapid, reproducible approach to quantify total plaque burden.
Disturbances in theta-beta band oscillations in precuneus and aberrant effective connectivity within default mode network as potential biomarkers of chronic schizophrenia: an EEG resting-state study
Authors: Adamczyk Przemysław , Domingos Christophe , Więcławski Wiktor , Wojcik Maja , Frycz Sandra , Panek Bartłomiej , Jáni Martin , Dudzińska Olga , Ros Tomas , Wyczesany Miroslaw
Published: October 2023

Schizophrenia is a complex psychiatric disorder with unknown neuropathology. Notably, the triple-network-model of psychiatric disorders, focusing on the default mode (DMN), central executive (CEN), and salience (SN) networks, proposes an interesting framework for investigating abnormal neurocircuit activity in schizophrenia. In the present study, we aim to explore the three resting-state EEG biomarkers: i) the relative power spectrum, ii) functional connectivity metrics - corrected imaginary phase locking (ciPLV) and iii) effective connectivity estimated by source-localization-based directed transfer function (DTF) in 28 chronic schizophrenia patients and 27 controls. The presented results revealed that schizophrenia is characterised by: i) the prevalence of high power at the theta band (4–8 Hz) localised at the centroparietal area, along with smaller but widespread alterations in frontotemporal regions; ii) the existence of widespread bilateral alterations in inter- and intra-hemispheric neural communication patterns, with the most significant difference, manifested in a reversed pattern of hemispheric engagement at theta and beta/gamma bands; iii) the observed multiband effective connectivity disturbances within the DMN were revealed as the most excessive, compared to the solely low-frequency alterations of CEN or SN negative ones; the most significant difference between group was manifested in a reversed direction of information flows at theta and beta bands, with a strong indication of the specific disturbances of key DMN node – the precuneus. In conclusion, our study presents novel insights into schizophrenia neuropathology, with a particular emphasis on the fronto-parietal connectivity alterations at theta/beta bands. This may be suggested as a promising clinical biomarker of chronic schizophrenia.
Morphological variability of 65 amaranth accessions from the Cajamarca Region, Peru
Authors: Ortiz Lucia Emperatriz Escalante , Padilla Angel Esteban Santa Cruz , Leiva Araceli Eugenio , Orrillo Jorge Luis Vasquez , Lopez Silvia Yanina Rodriguez , Morales Susan Haydee Soriano , Cunya Juan Fransisco Seminario
Published: October 2023

Amaranth is a promising crop for the Cajamarca region and Peru. The National Institute of Agrarian Innovation (INIA) from Peru preserves a national collection of 552 amaranth accessions; however, there needs to be a detailed study of the morphology of these materials. In this research, 65 accessions were morphologically characterized based on their place of origin, using 21 descriptors standardized by INIA-Peru. The clustering of accessions and principal component analysis showed the presence of 38 groups and a duplication rate of 41.5% of accessions at a taxonomic distance of 0.62. In addition, 18 morphological characters that significantly contributed to morphological variability were identified and explained by the first six principal components. Due to the scarcity of studies on amaranth, it is recommended to conduct more characterization and molecular studies to obtain better approximations of the genetic diversity of the amaranth germplasm to be used on amaranth plant breeding programs.
Pressure injury risk assessment for palliative care patients in the acute hospital setting: A scoping review
Authors: Ven Saroeun , Fulbrook Paul , Burston Adam , Lovegrove Josephine , Miles Sandra J
Published: October 2023

Background: Hospitalised palliative care patients are at risk of pressure injury. The development of pressure injuries causes physical and psychological distress for patients. Therefore, the prevention of hospital-acquired pressure injury is a nursing priority. The first step in prevention is conducting a risk assessment, which should be population-specific. In Australia, five palliative care phases guide care planning for appropriate clinical management of palliative care patients. In phases 1-3, the palliative patient cohort is based on acute care, where patients require medical treatment and/or symptom management, whereas Phase 4 refers to end-of-life care.
Objectives: To review and analyse contemporary literature to determine what is known about pressure injury risk assessment for acute palliative care patients and identify which pressure injury risk assessment tools are most appropriate for this cohort.
Methods:This scoping review was conducted according to Joanna Briggs Institute methodology. The search strategy was developed based on the Population-Concept-Context mnemonic. Studies of any design, articles and guidelines relating to pressure injury risk assessment in acute palliative care patients were included. Publications from 2002 to 2023 from Google Advanced Search, three grey literature and five nursing/health databases (Cumulative Index to Nursing and Allied Health Literature, MEDLINE, Scopus, Web of Science, EMBASE) were searched. The protocol was prospectively registered with Open Science Framework.
Results: From 2,576 search results, 15 articles met the inclusion criteria. None reported the use of a pressure injury risk assessment tool designed specifically for acute palliative care patients. However, 20 pressure injury risk assessment tools/methods were identified. Furthermore, the definition of palliative care patients was inconsistent, and no articles clearly defined the differences between acute palliative care patients and those at end-of-life.
Conclusions: The results of this review indicate a need to develop a new PI risk assessment tool for acute palliative care patients that considers their specific risk factors. Further research is needed to address the knowledge gap relating to pressure injury risk assessment and prevention for hospitalised acute palliative care patients.
Risk factors for secondary thyroid cancer in patients with breast cancer : a propensity‑matched SEER analysis
Authors: Diao Yizhuo , Wang Ruiqi , Cui Jiaxue , Jin Chenxin , Chen Yongxing , Li Xiaofeng
Published: October 2023

With the rapid development of imaging technology and comprehensive treatment in modern medicine, the early diagnosis rate of breast cancer is constantly improving, and the prognosis is also improving; With the prolongation of the survival period of breast cancer patients, the risk of multiple primary cancers may increase. Since both breast and thyroid are Hormone receptor sensitive organs, which are regulated by hypothalamus pituitary target gland endocrine axis, changes in body endocrine status may lead to the occurrence of these two diseases in succession or simultaneously. The clinical data and survival results of breast cancer patients registered in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2020 were extracted. After matching the data with propensity scores, patients were divided into a training group and a validation group using a 7:3 ratio. Univariate and multivariate COX proportional regression analysis is used to determine independent risk factors for secondary thyroid cancer and construct a column chart prediction model. Age, ethnicity, whether radiotherapy, tumor primary location, N stage, M stage were screened by Cox regression as independent factors affecting secondary thyroid cancer in patients with breast cancer patients, and a risk factor nomogram was established to predict patients' three- and five-year survival rates. The AUC values for three and five years in the training set were 0.713, 0.707, and the c -index was 0.693 (95% CI 0.67144, 0.71456), and the AUC values for three and five years in the validation set were 0.681, 0.681, and the c -index was 0.673 (95% CI 0.64164, 0.70436), respectively.
Exploration of Electromagnetic Resonance for Advanced CO2 Molecular Cracking: Towards a Revolution in Carbon Emission Management.
Authors: Mnaouer Khaled , Mghaiouini Redouane , Mouden Mahmoud El
Published: October 2023

This study focuses on optimizing the efficiency and selectivity of the CO2 cracking process using the method of experimental design and leveraging electromagnetic resonance. In a context where the utilization of CO2 as a valuable raw material is gaining increasing interest, the CO2 cracking process activated by electromagnetic resonance offers promising prospects. The experimental design method is implemented to deeply analyze the influential factors and their interactions within this process. Through a series of carefully designed experiments, the optimal parameters for achieving maximum CO2 conversion and increased product selectivity are determined. The results highlight the effectiveness of using electromagnetic resonance to facilitate the CO2 cracking process, while also highlighting its potential for the creation of high-value carbon-based products. This research contributes to the development of more efficient and sustainable methods for the utilization of CO2
Selective adsorption of tetracycline by β-CD-immobilizing sodium alginate aerogel coupled with ultrafiltration for reclaimed water
Authors: Quan Xi , Zhang Jun , Yin Linlin , Zuo Wei , Tian Yu
Published: October 2023

β-CD-immobilizing sodium alginate aerogel (β-CD/NaAlg) was fabricated using β-cyclodextrin (β-CD) as a modification reagent to eliminate tetracycline antibiotics from wastewater. β-CD/NaAlg aerogel with the β-CD/NaAlg molar ratio of 9 achieved the maximum removal rate of more than 70% for tetracycline in 8 h, 1.5 g/L of adsorbent dosage, and pH of 4. Tetracycline adsorption on β-CD/NaAlg aerogel was aligned with the Freundlich and pseudo-second-order model, showing that this process was mostly controlled by chemisorption. According to XPS analyses and DFT simulations, the tetracycline adsorption mechanism via β-CD/NaAlg aerogel is ascribed to electrostatic attraction through carboxyl groups and amido groups, hydrogen bonds connecting hydroxyl groups, as well as van der Waals forces. Besides, the as-prepared aerogel had a good reusability with the removal efficiencies of 55.3% for tetracycline even after repeating five times. Additionally, the couple of β-CD/NaAlg aerogel greatly improved selective separation performance for tetracycline antibiotics of the ultrafiltration membrane. In general, the synthesized β-CD/NaAlg aerogel is constructive for strategies to develop novel green, metal-free and stable adsorbent materials.
Effects of computer simulation on students performance and retention in kinetic theory of gas and Gas laws
Authors: Alabi Abdul-Hafiz Abolade , Mohammed Ridwan Enuwa , Balogun Basit Olatunji
Published: October 2023

Students' poor performance in both internal and external examinations has long been a source of concern for educators and other stakeholders. This poor performance has been linked to teachers' teaching quality and instructional strategies used. Therefore, this study aimed to determine the effect of computer simulation on students' performance and retention in the kinetic theory of gas and gas laws in Ilorin, Kwara State. The study was a quasi-experimental pre-test, post-test, non-randomized 2×2×2 factorial design. A total of 40 students from two randomly selected senior secondary schools were involved, including 17 students in the experimental group and 23 in the control group. The research instruments were a Physics Education Technology (PhET) simulation developed by the University of Colorado Boulder, a Physics Performance Test (PPT), and a Physics Retention Test (PRT). The reliability of both PPT and PRT was tested using KR-21 with indices values of 0.855 and 0.769, respectively. The research utilized the 5E Instructional model to implement the computer simulation. The research findings revealed that the experimental group had better performance and retention than the control group in the kinetic theory of gas and Gas laws. Also, there was no significant difference in the performance of students taught the kinetic theory of gas and gas laws (t=1.96, p=0.761, p>0.05). Also, although the experimental group's female students outperformed the male students, there was no significant difference in the students' performance in terms of gender (f=2.82, p=0.115, p>0.05). The study recommends that science teachers integrate cutting-hedge simulation into their instructional modes, especially when teaching physics. Also, there should be training for both pre-service and in-service science teachers on development and how to access appropriate computer simulations for their lessons.
A Survey Study on Lifelong Learning Perception and Practices in India: Assessing the Impact of NEP 2020
Authors: SWARGIARY KHRITISH
Published: October 2023

Abstract: The National Education Policy (NEP) 2020 in India emphasizes the importance of lifelong learning as a crucial aspect of personal and professional development. This research paper aims to investigate the perceptions and attitudes of individuals towards lifelong learning in the context of NEP 2020. A survey study was conducted among a diverse sample of participants to gather data on their awareness, understanding, and engagement with lifelong learning initiatives. The findings of this study provide insights into the potential impact of NEP 2020 on lifelong learning in India and offer recommendations for its effective implementation.
This research paper aims to shed light on the perceptions, understanding, and engagement of individuals towards lifelong learning in the context of NEP 2020. By conducting a survey study, valuable insights can be obtained regarding the effectiveness of NEP 2020 in promoting lifelong learning and addressing the challenges associated with it. The findings of this study will contribute to the existing literature on lifelong learning and assist policymakers in implementing appropriate measures to encourage lifelong learning in India's future.
Strategic International Asset Allocation under a Quadratic Model with Exchange Rate and Inflation-Deflation Risks
Authors: Kusuda Koji , Kikuchi Kentaro , Batbold Bolorsuvd
Published: October 2023

This study considers a consumption and international investment problem under a quadratic model, where interest rates, the market price of risk, the variances and covariances of asset returns, inflation rates, and exchange rates are stochastic. We assume that the state vector consists of the global state and the currency-specific state, which are independent. We derive the optimal consumption and international portfolio analytically. We obtain the following results: i) The indirect utility function, optimal consumption, and optimal investment depend not only on each of the global state and the currency-specific state, but also on the interaction of the two states; ii) The optimal international portfolio is a nonlinear function not only of the global state but also of the currency-specific state, and depends on the currency-specific state, the domestic market price of currency-specific risk, the differences between the domestic and foreign market prices of global risk and of currency-specific risk, in addition to the global state and the domestic market price of global risk. These results suggest that the market timing effects are more important in the international portfolio than in the domestic portfolio.
Aufgabenentwicklung für einen inklusiven Kunstunterricht. Zu einem Spannungsfeld zwischen Re- und Dekategorisierung
Authors: Kaiser Michaela
Published: October 2023

Aufgaben in einem inklusiven Kunstunterricht werden mehrheitlich als eine Praxis verstanden, die auf Lern- und Leistungsunterschiede reagiert und diese zu bearbeiten sucht – liegt diesen doch die Vorstellung einer möglichst optimalen Lern- und Leistungsentwicklung zugrunde. Im Rahmen des Beitrags werden entwicklungsorientierte Bildungsziele des Kunstunterrichts nach­gezeichnet und unter Rückgriff auf praxeologische und performative Theorienbestände wird aufgezeigt, dass die Konstruktion entwicklungsorientierter Aufgaben im Kunstunterricht nicht allein als Reaktion auf Differenz und als Bearbeitung von Differenzverhältnissen, sondern auch als an der Erzeugung von Differenzen und damit als an der (Re-)Produktion von Normen und Hierarchisierungen aktiv beteiligt verstanden werden kann. Diese Perspektivierung eröffnet den Blick auf die ambivalenten Effekte des oft konstitutiven Bezugs auf Lern- und Leistungs­differenzen in der Konstruktion kunstunterrichtlicher Aufgaben. In einem abschließenden Schritt werden Anfragen an eine dekonstruktive Lesart kunstunterrichtlicher Aufgaben gestellt.
 
Abstract
Tasks in an inclusive arts classroom are widely understood as a practice that responds to and seeks to address differences in learning and performance - this is based on the notion of optimal learning and performance development. In the context of this article, development-oriented educational goals of art class are traced and, with recourse to praxeological and performative theories, it is shown that the construction of development-oriented tasks in art class cannot be understood solely as a reaction to difference and as a processing of relations of difference, but also as actively involved in the production of differences and thus in the (re)production of norms and hierarchizations. This perspectivization provides a view of the ambivalent effects of the often constitutive reference to learning and performance differences in the construction of tasks in art class. In a concluding step, questions are raised about a deconstructive reading of art instructional tasks.
PRIMARY FALLOPIAN TUBE CANCER: A LITERATURE REVIEW
Authors: Sumtsov Dmitrii
Published: October 2023

This literature review presents an analysis of diagnostic methods and treatment of a relatively rare and highly malignant tumor – primary fallopian tube cancer, which is poorly studied and difficult to diagnose. The study of the fallopian tube disorder is very relevant, as the fallopian tube mucosa can be a source of "serous carcinogenesis" for serous ovarian and peritoneal cancer.
The author selected more than 50 scientific works from the world literature on the problems of incidence, diagnosis, and treatment of primary fallopian tube cancer and conducted a detailed analysis of them.
The author draws attention to the risk group for primary fallopian tube cancer. Women with BRCA-1 and BRCA-2 mutations are more likely to develop FTC, especially in families with a history of breast and (or) ovarian cancer. Approximately 30% of women with FTC have a BRCA-1 or BRCA‑2 mutation. All patients with a burdened history and pathologic mutations should be considered candidates for routine rehabilitation. The author analyzes options for improving preoperative diagnosis using modern methods of additional examination, such as tumor markers, vacuum suction biopsy, transvaginal ultrasound, CT and MRI, and diagnostic laparoscopy. The author emphasizes that it is possible to avoid diagnostic errors during operations using a detailed examination of the affected fallopian tube mucosa on a longitudinal section and suboperative methods of morphological diagnosis. In addition, the author points out the prognostic importance of adequate staging and complete courses of adjuvant polychemotherapy according to modern clinical protocols. The author also draws attention to the interdependence of prevention methods, diagnosis, and treatment of FTC and ovarian cancer.
CONTEMPORARY OPINIONS ON THE PECULIARITIES OF ORAL MUCOSA WOUNDS HEALING: A LITERATURE REVIEW
Authors: Domysche Marjan , Mochalov Iurii
Published: October 2023

The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information.
Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information.
Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative.
Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.
ANALYSIS OF THE PREVALENCE OF DISABILITY IN THE CHILDREN POPULATION IN POLTAVA OBLAST IN 2018–2022
Authors: Khorosh Maksym
Published: October 2023

The aim of the study is to analyze the situation with child disability in the Poltava region for 2018–2022, investigate its main trends, and analyze the structure of the causes that lead to children's disabilities.
Materials and Methods. The study design is descriptive. The conducted study involved methods of social medicine: medical-statistical and structural-logical analysis. The statistical data of the State Statistics Service of Ukraine were taken as the study materials. To obtain results, calculations of generally accepted indicators (disability, primary disability, specific gravity) and analysis of statistical series was carried out.
Results. It was established that during the studied period, the level of disability in the child population in the Poltava region was higher than the national level and it remains relatively stable (from 228.28 per 10,000 children in 2018 to 228.96 per 10,000 children in 2022). At the same time, the level of primary disability of the child population during the study period was lower than the national level and showed a downward trend (from 23.98 per 10,000 children in 2018 to 20.57 per 10,000 children in 2022). The gender structure of both indicators showed that the specific weight of boys was higher than that of girls, and there was also an increase in the level of indicators among boys and a decrease among girls. The main causes of disability in the Poltava region were congenital anomalies (26.26%), mental and behavioral disorders (23.45%), diseases of the endocrine system (12.99%), which corresponded to the structure of the disability causes in Ukraine. Regarding primary disability, the main reasons were mental disorders (30.60%, a gradual increase in specific gravity is observed), endocrine problems (18.32%), and congenital anomalies (17.46%).
Conclusions. During the studied period, there was a trend towards an increase in primary disability. In the structure of disability and primary disability, an increase in the specific weight of boys was observed. In the structure of disability, the first place was occupied by mental disorders, and during the studied period, there was a tendency to increase. In the Poltava region, in contrast to Ukraine, endocrine problems take the second place. Based on such a picture, it can be concluded that in order to improve children's health, attention should be paid to the psychological health of children and the preventive component of risk factors should be strengthened.