bluuebunny/crossref_metadata_2025 huggingface dataset:
Monográfico: Perspectivas Actuales de Evaluación e Intervención en Atención Temprana
Authors: Romero-Galisteo Rita Pilar , Barajas Carmen , Gálvez-Ruiz Pablo
Published: September 2021

Tradicionalmente la Atención Temprana (AT) ha sido un ámbito de estudio que ha visto incrementado el interés científico tanto en Europa como en Norteamérica, no siendo distinto en España, donde algunos investigadores ofrecen interesantes resultados para mejorar tanto la evaluación como la intervención en la práctica diaria. Actualmente se utiliza el concepto de AT, que sustituye al originario de “estimulación precoz”, que es como inicialmente se llamó a este ámbito de intervención (Robles-Bello y Sánchez-Teruel, 2013). El Grupo de Atención Temprana (2005) la define como: El conjunto de intervenciones dirigidas a la población infantil de 0-6 años, a la familia y al entorno, que tienen por objetivo dar respuesta lo más pronto posible a las necesidades transitorias o permanentes que presentan los niños con trastornos en su desarrollo o que tiene el riesgo de padecer los (p. 13).
Effect of chlorophenoxy herbicides residues on probing behavior of cereal aphid
Authors: KRZYŻANOWSKI ROBERT , BEDNARCZYK IZABELA , CUDZIŁO-ABRAMCZUK JOLANTA
Published: September 2021

Chlorophenoxyacetic herbicides such as 4-chloro-2-methylphenoxyacetic acid (MCPA) and 2,4-dichlorophenoxyacetic acid (2,4-D) are used for cereal protection. However, some of them penetrate the tissues of protected plants and also get in contact with cereal pathogens. The up-to-date studies concerned their effectiveness in combating the weeds without paying attention to the herbivores occurring in cereal agrocenoses. Therefore, the aim of the present study was to determine the effect of chlorophenoxyacetic herbicides on the probing behavior of grain aphid, Sitobion avenae (F.), bird cherry-oat aphid, Rhopalosiphum padi (L.) and rose-grain aphid, Metopolophium dirhodum (Walk.). The experiment was carried out on wingless females feeding on winter wheat seedlings of Tonacja cv. using the electronic penetration graph (EPG) method. Tested herbicide preparations exerted an influence on the probing behavior of all aphids examined. The inhibitory effect of MCPA and 2,4-D on the uptake of phloem juice was found. It has been shown that chlorophenoxyacetic herbicides are not only effective in combating the weeds of cereal crops, but can also have positive side-effects in the form of limiting the cereal aphids population.
The effect method of preservation on selected bioactive compounds and antioxidant activity in blackthorn fruits (Prunus spinosa L.)
Authors: OLESIŃSKA KATARZYNA , WILCZYŃSKI KAMIL , KAŁWA KLAUDIA
Published: September 2021

The effect of freezing (M), freeze drying (L) and convection drying (S) of blackthorn fruits on the content of selected bioactive compounds and antioxidant properties compared to the control sample – fresh fruit (PK), was tested. Changes in the content of flavonoids, anthocyanins, pectins, general acidity and the ability to reduce the DPPPH radical, were determined. The obtained results showed that the freeze-dried fruits had the highest content of anthocyanins and flavonoids, respectively 0.07 and 0.17%. Pectin contents in freeze-dried and convectively dried fruits were similar at the level of 1.66 and 1.64% as well as for acidity respectively 0.076 and 0.071 g·100 g–1 infusion. Frozen fruits did not differ significantly compared to the control in terms of the content of anthocyanins, flavonoids, pectin and acidity. The highest scavenging capacity of free radical DPPH was characterized by the infusion obtained from fresh fruits.
Nephrotic Syndrome Associated with Hydronephrosis and Unilateral Renal Agenesis
Authors: Larisia Mihai , Viviana Cuzic , Adina Ungureanu , Corina Frecus , Adriana Balasa , Claudia Cambrea
Published: September 2021

We reported a case of nephrotic syndrome in a child presenting undiagnosed hydronephrosis and unilateral renal agenesis in a 3 years and 9 months old male patient presenting features of nephrotic syndrome, with left hydronephrosis and unilateral renal agenesis. The association of nephrotic syndrome with congenital anomalies is extremely rare. The importance of this unusual combination was discussed respecting the literature.
PD-L1 and CD8-Tumor-Infiltrating Lymphocytes Expression in Laryngeal Squamous Cell Carcinoma
Authors: Oana Cojocaru , Mariana Aschie , Anca Nicolau Antonela , Ionut Burlacu , Manuela Enciu , Izabela Baltatescu Gabriela
Published: September 2021

Studies in recent years have shown that the immune system plays an important role in the prognosis of patients with different types of malignancies. The tumor immune microenvironment has been studied in various cancers in an attempt to find new antitumoral therapies. The therapeutic blockade of PD-1/PD-L1 has revolutionized the treatment of oncological pacients, with anti-PD-L1 monoclonal antibodies having remarkable results in malignant melanoma, cervical, renal and lung cancer. In laryngeal cancer, few reports are available on the immune microenvironment and PD-L1 expression. Considering these, we retrospectively review 23 laryngeal cancer patients with laryngectomy performed in the Otorhinolaryngology Department - Emergency County Clinical Hospital St Andrew Constanta. The aim of our research was to evaluate the immunohistochemical expression of PD-L1, using combined positive score which includes both viable tumoral cells and intratumoral lymphocytes, as well as the level of CD8 intratumoral lymphocytes and to analise the corelation between these markers and the clinicopathological characteristics of the pacients, in order to set these two parameters, in the near future, as new biomarkers. PD-L1 expression was shown to be a prognostic factor for disease-free survival in laryngeal cancer patients (p = 0.006) and was higher in tumors with elevated CD8 lymphocyte levels, with a significant correlation correlation between the two parameters (p = 0.019). The level of CD8 lymphocytes was also a predictive factor for free-disease survival, correlated with patient smoker status (p = 0.04), being higher in non-smoking patients.
About Lung Cancer in Romania and Constanta County
Authors: Beatrice Severin , Valentin Broasca Madar , Elena Mocanu , Oana Ionita , Sergiu Chirila
Published: September 2021

Abstract: In Romania lung cancer represents the second most common cancer after breast cancer, for both sexes, and is the leading cause of death among patients with cancer.

Between 2011 and 2019 the incidence of cancer had a growing trend for both Romania and Constanta County. Unfortunately, the forecast regarding the incidence of cancer in Romania shows a trend of continuous rise of new cancer cases until 332.7%000 inhabitants by 2025.

In these conditions we wanted to analyze some aspects of lung cancer situation in Constanta County.
Quercetin improves myocardial redox status in rats with type 2 diabetes
Authors: Gorbenko Nataliia I. , Borikov Oleksii Yu. , Kiprych Tetiana V. , Ivanova Olha V. , Taran Kateryna V. , Litvinova Tetiana S.
Published: September 2021

Objective. Emerging data indicate that oxidative stress is closely associated with the pathogenesis of cardiovascular disease in type 2 diabetes mellitus (T2DM). The present study aimed to assess the effect of the most abundant flavonoid in the human diet quercetin (Q) on the myocardial redox status in rats with T2DM.

Methods. T2DM was induced in male Wistar rats by a high caloric diet (for 14 weeks) and two streptozotocin (25 mg/kg b.w.) injections applied in four weeks of the diet, once a week for two weeks. The Q was administered intragastrically by gavage in a dose of 10 or 50 mg/kg of the body weight for 8 weeks starting from the 8th day after the last streptozotocin injection. The control rats received citrate buffer and seven days after the last STZ injection, basal glucose levels were measured in all animals.

Results. Administration of Q increased insulin sensitivity in diabetic rats with more pronounced effect at a dose of 50 mg/kg b.w. The Q also decreased free radical oxidation in the heart mitochondria of diabetic animals, thus limiting the formation of advanced oxidation protein products in a dose-dependent manner and normalized the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase) in cardiac mitochondria independently of the dose used. In addition, the Q in both doses prevented the development of oxidative stress in the T2DM rats cardiomyocytes by reducing NADPH oxidase and xanthine oxidase activities.

Conclusions. The findings demonstrate that Q in both doses 10 mg/kg and 50 mg/kg can protect from the development of oxidative stress in cardiomyocytes in the diabetic rats. The present data indicate that the use of Q may contribute to the amelioration of cardiovascular risk in patients with T2DM.
Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress
Authors: Osacka Jana , Koprdova Romana , Tillinger Andrej , Pirnik Zdenko , Kiss Alexander
Published: September 2021

Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are associated with psychiatric diseases and stress response. Chronic mild stress (CMS) may alter BDNF as well as GR levels in both the PFC and the HIP. The aim of the present study was to find out whether chronic treatment with a typical antipsychotic haloperidol (HAL) and an atypical antipsychotic aripiprazole (ARI) may modify the CMS effect on the BDNF and GR expression in the above-mentioned structures.

Methods. The rats were exposed to CMS for 3 weeks and from the 7th day of CMS injected with vehicle (VEH), HAL (1 mg/kg) or ARI (10 mg/kg) for 4 weeks. BDNF and GR mRNA levels were established in the PFC and the HIP by Real Time PCR, whereas, PFC and HIP samples were obtained by punching them from 500 µm thick frozen sections. C-Fos immunoreactivity was analyzed in the PFC and the HIP on 30 µm thick paraformaldehyde fixed sections. Weight gain and corticosterone (CORT) levels were also measured.

Results. The CMS and HAL suppressed the BDNF and GR mRNA levels in the PFC. In the HIP, CMS elevated BDNF mRNA levels that were suppressed by HAL and ARI treatments. The CMS decreased the c-Fos immunoreactivity in the PFC in both HAL- and ARI-treated animals. In the HIP, HAL increased the c-Fos immunoreactivity that was again diminished in animals exposed to CMS. Stressed animals gained markedly less weight until the 7th day of CMS, however, later their weight gain did not differ from the unstressed ones or was even higher in CMS+HAL group. Un-stressed HAL and ARI animals gained less weight than the VEH ones. Neither CMS nor HAL/ARI affected the plasma CORT levels.

Conclusion. The present data indicate that HAL and ARI in the doses 1 mg/kg or 10 mg/kg, respectively, does not modify the effect of the CMS preconditioning on the BDNF and GR mRNA levels in the PFC or the HIP. However, HAL seems to modify the CMS effect on the HIP activation.
A Clinical Case of Acute Polyarthritis Unmasking Severe Comorbidity
Authors: Ciotoracu Andra Carmina , Dună Mădălina , Predeţeanu Denisa , Busuioc Constantin-Ioan , Alexandru Săvulescu Florin , Aramă Bogdan , Ion Ștefan
Published: September 2021

Acute polyarthritis requires a comprehensive differential diagnosis in order to establish its etiology. Moreover, sometimes it may unfold unexpected comorbidities, thus necessitating an individualized management approach.

This article describes the case of an elderly patient whose initial presentation of acute polyarthritis was interpreted as crystal induced-arthritis demonstrated by the presence of calcium pyrophosphate and lipid crystals in the synovial fluid. The clinical deterioration of the patient along with the suspicion of a systemic infection required interdisciplinary collaboration and led to his transfer to the infectious diseases department where the diagnosis of sepsis from unknown origin was added. Further investigations unmasked a large complicated pancreatic pseudocyst that eventually ruptured into the peritoneal cavity and led to the patient's death.
Analysis of an inverted square SRR via design of experiment (DoE) approach
Authors: Yarici Ismail , Öztürk Yavuz
Published: September 2021

A design of experiment (DoE) study is presented based on an investigation of the influences of the chosen geometric parameters of an Inverted Square Split Ring Resonator on its resonance frequency. A statistical software was used to determine DoE steps and the values of chosen geometrical parameters for the experiments. The determined experiments were carried out by making simulations with electromagnetic design software. The resonator simulation outputs were analyzed by using normality tests and tools of the statistical software. By using these analyses, mainly a 2-level full factorial DoE approach, the effects of the geometrical parameters (input factors), and their interactions on the resonance frequency (response factor) were presented. In the light of our findings, this study proposes a promising path for microwave studies with several advantages such as being able to understand the dynamics of an optimized RF resonator device system, designing these kinds of devices with a few experiments, and increasing the time efficiency via reducing the number of attempts.
THE HISTORY OF ECONOMIC DEVELOPMENT OF THE NORTHERN TERRITORIES - THE GOLD OF YAKUTIA: KОCHULUKAN AND YNYKCHAN IN THE POST-WAR PERIOD (MEMOIRS OF THE OWNER)
Authors: Grushina O. V. , Grushina A. I.
Published: September 2021

The paper is devoted to a part of A. M. Ozhigov‟s memoirs, recently found in the family archives of the authors. The memoirs describe the working conditions at the gold mines of the Dzhugdzhurzoloto trust in 1947. The post-war period required an urgent replenishment of the state gold reserves, which was reflected in the Decree of the Council of Ministers of the USSR (1946) on increasing the production of gold and platinum in the country. As a result, the Special Main Directorate of the USSR Ministry of Internal Affairs (Glavspetstsvetmet) has been created. The activity of this Directorate was focused on the search and exploration of new deposits, technical modernization and improvement of working conditions in mines This period of profound post-war crisis of gold industry, entirely determined by the war efforts, was characterized by a high share of manual labor, labor of prisoners and special settlers, low qualifications of workers and arduous living conditions. Here, we have evaluated reliability of the above memoirs using a comparative historical method. The factual knowledge of the memoirs was confirmed in open official sources. However, these sources are rather scarce in terms of human relations directly in gold mines and newly discovered areas. New names and circumstances of the everyday life of gold prospectors developing the deposit of the Kоchulyukan spring, brightly presented in the memoirs of A. M. Ozhigov, reveal the unknown details of the Soviet history of the industrial development of the northern territories. The psychological aspect of the recollections, expressed in the author's vivid subjectivism in relation to the organizers of the works (managers), also brightly show the opposition of the "worker-boss" type. Scanned copies of A. M. Ozhigov‟s memoirs are kept in the V. F. Vereshchagin Museum of Local Lore, Bodaibo town, Irkutsk region.
ALEXANDER II MODERNIZATION AS A CIVILIZATION CHOICE OF SOCIETY
Authors: Popova A. D.
Published: September 2021

The article investigates the reforms introduced by Alexander II through the prism of a comparative analysis of western and eastern civilizations. The author maintains that, having long developed as eastern civilization, Russia is characterized by oriental despotism, absence of a constructive dialogue between government and society, paternalistic social consciousness, legal nihilism. The author assesses historical data on reforms implemented by Alexander II and comes to the conclusion that the reforms signified an attempt to converge with western civilization. Alexander II‟s reforms enhanced the importance of law, highlighted the principle of everyone‟s equality before the law, encouraged a constructive dialogue between government and society, and underlined the inadmissibility of plenipotentiary autocratic power and despotism. However, since it is not easy to change public mind, western innovations remained closely associated with oriental traditions, such as the importance of community, paternalism, and legal nihilism. The author concludes that though Alexander II‟s reforms introduced some elements of western civilization, Russian society remained essentially oriental.
ACTIVITIES OF THE SPIES OF ATAMAN NECRASOV IN THE TERRITORY OF THE RUSSIAN STATE (1708 - 1720s). Part 1
Authors: Senˈ D. V.
Published: September 2021

The author investigates the reasons, forms and methods of sending spies from the territory of the Kuban, part of the Crimean Khanate. The spies "subversive" activities were most often directed by the ataman Ignat Nekrasov. For the first time in academic literature, the author systematically analyzes the tasks assigned to these Nekrasov‟s spies, as well as the conditions that both facilitated and hindered their implementation. Achieving the goal and objectives of this article, general investigative and special historical methods are used. The article is based on written historical sources of XVIII c. from several Russian federal and regional archives. The paper focuses on the geography of the "subversive" activities of such people, their composition and the peculiarities of training to perform tasks that are not always associated with the collection of intelligence information on the territory of Russia. In addition, the reactions of various categories of Russian citizen who communicated with the Ignat Nekrasov‟s spies are identified and studied. Numerous search activities and preventive measures of the Russian authorities aimed at suppressing / preventing the activities of the Nekrasov‟s spies, as well as at their capture and organization of interrogations are systematically analyzed.
How COVID-19 quarantine might affect the sleep of children and adolescents?
Authors: Richter Samanta , Schilling Luisa , Camargo Nathália , Taurisano Melissa , Fernandes Nathália , Silva Luis Eduardo , Nunes Madga
Published: September 2021

OBJECTIVES: To describe the main aspects of altered sleep in children and adolescents in the quarantine of COVID-19. METHODS: A narrative review of the current literature on the topic was carried out, based on the most recent national/international classification. RESULTS: The literature on the subject is still scarce. The sudden changes in routines and transfers of classes to virtual models provided flexibility in school activities, impacting the circadian rhythm of children and adolescents and, consequently, sleep. As a result, the lack of a routine with pre-established schedules by parents, results in longer use of electronic devices, from games to the media. CONCLUSIONS: It is essential that pediatricians advise parents on the importance of establishing a routine of daytime and nighttime activities, which will have an impact on the quality of sleep of children and adolescents during this quarantine period.
The Dialectics of Technology Standardization
Authors:   University of Gothenburg, Lindgren Rikard ,   University of Borås, Mathiassen Lars ,   Georgia State University, Schultze Ulrike ,   Southern Methodist University
Published: September 2021

Technology standardization unfolds as a dialectic process marked by paradoxical tensions. However, standardization research has yet to provide a dialectic analysis of how tensions and management responses interact recursively over time, and with what effect. In this paper, we apply dialectics to analyze an action research study of a Swedish initiative that developed and diffused a technology standard to facilitate the integration of disparate IT systems in road haulage firms. Drawing on the technology standardization literature and our empirical analysis, we engage in midrange theorizing to capture the recursive dynamics through which standard-setters construct and respond to manifestations of three latent tensions: development versus diffusion activities, private versus public interests, and local versus global solutions. Our resulting dialectic theorizing explicates how standard-setters bring these latent tensions into being; how they construct salient tensions through the oppositional logics of polarization, complementarity, and mutuality; how they manage these tensions through splitting, integrating, and suspension responses; and how consequential functional, architectural, and organizational standardization outcomes produce a new social order in which new tensions emerge. These theoretical insights contribute to both the technology standardization and dialectics literatures.
The Impact of the Sharing Economy on Household Bankruptcy
Authors:   University of California, Irvine, Nian Tingting , Zhu Yuyuan (Anthony) ,   T. Rowe Price Group, Inc., Gurbaxani Vijay ,   University of California, Irvine
Published: September 2021

Powered by digital technologies, many peer-to-peer platforms, or what is called the sharing economy, have emerged in the past decade. Although the impact of the sharing economy has received considerable attention over the past few years, extant research has not fully documented the impact of the sharing economy on consumers, workers, industry, or society as a whole. In this study, we exploit the geographical and temporal variation in Uber’s entry to examine its impact on the personal bankruptcy rate as well as on other consumer credit default rates. We empirically document the changes in personal bankruptcy filings after Uber’s entry, and show that personal bankruptcy filings under Chapter 7 experience a drop of 0.047 per 1,000 people after Uber enters a county, which translates to a 3.26% reduction in quarterly bankruptcy filings. Uber’s entry also leads to a reduction in Chapter 13 personal bankruptcy filings, but to a smaller degree (0.018 cases per 1,000 people per quarter). We check the validity of our estimates using business bankruptcy filings, which we find are uncorrelated with Uber’s entry.
Is AI Ground Truth Really True? The Dangers of Training and Evaluating AI Tools Based on Experts’ Know-What
Authors:   University of Virginia, Lebovitz Sarah , Levina Natalia ,   New York University, Lifshitz-Assa Hila ,   New York University
Published: September 2021

Organizational decision-makers need to evaluate AI tools in light of increasing claims that such tools out-perform human experts. Yet, measuring the quality of knowledge work is challenging, raising the question of how to evaluate AI performance in such contexts. We investigate this question through a field study of a major U.S. hospital, observing how managers evaluated five different machine-learning (ML) based AI tools. Each tool reported high performance according to standard AI accuracy measures, which were based on ground truth labels provided by qualified experts. Trying these tools out in practice, however, revealed that none of them met expectations. Searching for explanations, managers began confronting the high uncertainty of experts’ know-what knowledge captured in ground truth labels used to train and validate ML models. In practice, experts address this uncertainty by drawing on rich know-how practices, which were not incorporated into these ML-based tools. Discovering the disconnect between AI’s know-what and experts’ know-how enabled managers to better understand the risks and benefits of each tool. This study shows dangers of treating ground truth labels used in ML models objectively when the underlying knowledge is uncertain. We outline implications of our study for developing, training, and evaluating AI for knowledge work.
Development of the Commercial Manufacturing Process for Ipatasertib
Authors: Bachmann Stephan , Iding Hans , Lautz Christian , Thomé-Pfeiffer Isabelle , Maierhofer Caroline , Mondière Régis , Schmidt Philipp , Strasser Christoph , Bär Thomas , Aebi André , Schuster Andreas
Published: September 2021

Ipatasertib is a potent small molecule Akt kinase inhibitor currently tested in Phase III clinical trials for the treatment of metastatic castration-resistant prostate cancer and triple negative metastatic breast cancer. In this paper an overview of the development achievements towards the commercial manufacturing process is given. The convergent synthesis consists of ten steps with eight isolated intermediates and utilizes a wide range of chemical techniques and technologies to build-up this complex drug. All three stereocenters are introduced using enzyme or metal catalysis.
Quantification and Clustering of Inorganic Nanoparticles in Wastewater Treatment Plants across Switzerland
Authors: Mehrabi Kamyar , Kaegi Ralf , Günther Detlef , Gundlach-Graham Alexander
Published: September 2021

Single particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry (sp-ICP-TOFMS), in combination with online microdroplet calibration, allows for the determination of particle number concentrations (PNCs) and the masses of elements in individual particles. Because sp-ICP-TOFMS analyses of environmental samples produce rich datasets composed of both single-metal nanoparticles (smNPs) and many types of multi-metal NPs (mmNPs), interpretation of these data is well suited to automated analysis schemes.  Here, we present a data analysis approach that includes automatic particle detection and elemental mass determinations based on online microdroplet calibration, and unsupervised clustering analysis of mmNPs to identify unique classes of NPs based on their element compositions. To demonstrate the potential of our approach, we analyzed waste water samples collected from the influent and effluent of five wastewater treatment plants (WWTPs) across Switzerland. We determined elemental masses in individual NPs, as well as PNCs, to estimate the NP removal efficiencies of the individual WWTPs. Through hierarchical clustering, we identified NP classes conserved across all WWTPs; the most abundant particle types were those rich in Ce-La, Fe-Al, Ti-Zr, and Zn-Cu.  In addition, we found particle types that are unique to one or a few WWTPs, which could indicate point sources of anthropogenic NPs.
PHILOSOPHY AND SCIENCE: THE PROBLEM OF INTERACTIVE CORRELATION
Authors: Ильин Виктор Васильевич , Сапегина Ольга Петровна , Яловенко Яна Викторовна
Published: September 2021

Наука и философия - принадлежа различным ареалам когитальной культуры - дополняют друг друга. Знание предметоцентрично, метафизика идеалоцентрична, но они равным образом обслуживают запросы человека как существа символического, погруженного в условное, однако стремящегося достичь безусловного. Ресурсы науки с ее жесткими правилами в деле перекрытия барьеров условностей непригодны. Надежду вселяет метафизика, духовно осваивающая существование в менее ригидных рамочных кондициях.

Science and philosophy, belonging to different areas of cogitative culture, complement each other. Knowledge is object-centered; metaphysics is aimed at the ideal meanings, but equally serves the needs of man as a symbolic being, involved in the conditional circumstances, but striving to achieve the unconditional. The resources of science with its rigid rules are not suitable for overcoming the barriers of conventions. Metaphysics is able to support hope dealing with spiritual mastering of the world under the less rigid framework conditions.
«WORK ON MYTH»: THE FAMILY LEVEL
Authors: Иванов Андрей Геннадиевич
Published: September 2021

Оценивается применимость взаимосвязанного (ситуационного) подхода к мифу в отношении интерпретации нарративов о семейной памяти. Повседневная мифология семейной памяти понимается как особое пространство актуализации социальной мифологии, включающее преломление автобиографической памяти, семейного опыта в сферах повседневности. Отмечается, что в случае с семейными историями «работа над мифом» охватывает все виды бытия мифа - от индивидуального до социетального. Для характеристики совокупности постоянно воспроизводящихся в семейных рассказах и практиках мифологизированных представлений предлагается использовать термин «семейный мифоландшафт», конфигурация которого специфична для каждой семьи, но содержит устойчивые компоненты.

The Russian Presidential Academy of National Economy and Public Administration, Lipetsk Branch, Lipetsk The article assesses the applicability of the interrelational approach to myth in the perspective of interpretation of narratives nourished by family memory. Everyday mythology of family memory is understood as a special space of actualization of social mythology, which includes the refraction of autobiographical memory, family experience in the spheres of everyday life. It is noted that in the case of family stories, «work on myth» covers all types of myth existence - from individual to societal. To characterize the totality of mythologized representations that are constantly reproduced in family stories and practices, it is proposed to use the term «family mythscape», the configuration of which is specific for each family, but contains stable components.
IDEAS AS SOCIAL PROCESS MANAGEMENT TECHNOLOGIES
Authors: Равочкин Никита Николаевич
Published: September 2021

В последние годы целый ряд исследователей соглашается с тем, что идеи наряду с материальными факторами способствуют построению каких-либо объяснений социальных преобразований. В то же время, существует устойчивое и резко противоположное мнение, что идеи сами по себе являются исключительно теоретически перегруженными конструктами, которые в принципе мало что значат. Важным замечанием представляется инструментальная роль идей в преодолении ограниченной рациальности различных акторов, без обращения к которым они вряд ли достигли бы желаемых прагматических эффектов совершенных действий. Настоящая статья посвящена прикладному значению идей, которые воплощаются в целые технологии управления социальными процессами. Обоснована значимость интеллектуальных ресурсов в контексте Постсовременности. Показано, что представляют собой современные технологии социального управления. Выявлено место идеальных элементов в структуре управления процессами. В логике авторского подхода рассмотрены примеры дистрибуции идей от генезиса до их практической реализации в различных сферах общественной жизни. Уточнена инновационность идей, к которым перманентно обращаются акторы. Актуализировано состояние манипулятивных практик, к которым вынуждены прибегать властные субъекты. Приведена классификация идей, задающих концептуальные основания альтернативных утилитарных действий. В заключение обобщаются основные выводы и подводятся итоги исследования.

In recent years, a number of researchers have agreed that ideas, along with material factors, contribute to the construction of any explanations for social transformations. At the same time, there is a stable and sharply opposite opinion that ideas in themselves are exclusively theoretically overloaded constructs that, in principle, mean little. An important remark is the instrumental role of ideas in overcoming the limited rationality of various actors, without recourse to which they would hardly have achieved the desired pragmatic effects of committed actions. This article is devoted to the applied meaning of ideas that are embodied in whole technologies for managing social processes. The importance of intellectual resources in the context of Postmodernity has been substantiated. It is shown what modern technologies of social management are. Revealed the place of ideal elements in the structure of process management. In the logic of the author's approach, examples of the distribution of ideas from genesis to their practical implementation in various spheres of public life are considered. Clarified the innovativeness of ideas to which actors are permanently referring. The state of manipulative practices that powerful subjects are forced to resort to has been updated. A classification of ideas defining the conceptual foundations of alternative utilitarian actions is given. In conclusion, the main findings are summarized and the results of the study are summed up.
DO UNIVERSAL (TIMELESS) VALUES EXIST? ETHICAL PROJECT OF MORITZ SCHLICK
Authors: Давлетшина Анна Маратовна
Published: September 2021

Реконструируется этическая философия М. Шлика и акцентируется внимание на темпоральных аспектах его этики. Для этого анализируется его последняя работа «Вопросы этики», где он предпринимает попытку научного рассмотрения морали. Отмечается, что для начала ХХ века характерно обращение к рассмотрению ценностей, т. к. «старый» набор ценностей, дискредитированный во многом войной и последующим изменением общества, больше не мог «закрепить» человека в текучей современности. Делается вывод, что этика Шлика представляет собой результат тонкого чувствования изменяющегося времени с его потребностью в переосмыслении всех оснований культуры - начиная с того, как мы познаем этот мир, и заканчивая тем, как нам жить и действовать в этом мире.

The article aims at reconstructing philosophical ethics developed by Moritz Schlick and at outlining its relation to temporality. We analyze in greater detail Schlick's last work 'Problems Of Ethics', in which he addresses the problems of philosophical reflection on morality. We place Schlick's work into the historical context of the early twentieth century, which can be characterized by an increased interest in values because the 'old' values were dismantled by world war and major social transformations. Human life and its meaning required renewed forms of orientation and meaning in «liquid modernity». In this respect Schlick's ethical reflection originates in the Zeitgeist with its search for new meaning of human life. For Schlick, the key question is why human beings act morally. To answer this question, Schlick investigates central concepts of ethics from the perspective of human activity. He also distinguishes his ethics of the good which relies on human nature, from the rationalistic ethics of duty, which, in his view, causes but alienation from life. Morality does not have to hinge on selfabnegation, while true virtue can be based on pleasure principle and remain independent from social pressures. Virtue can evolve from human free will and involve both reason and feelings. Thus, we argue that Schlick's heightened sensitivity to the spirit of the times with its need to reimagine the foundations of our culture shaped his approach to and his main concerns in ethical reflection, which embraced both the ways we can know the world and the ways we should live and act in it.
M. HEIDEGGER’S METAPHYSICS OF FINITENESS: HISTORY AS THE SUBJECT AREA OF UNDERSTANDING
Authors: Губман Борис Львович , Ануфриева Карина Викторовна
Published: September 2021

Статья ориентирована на анализ М. Хайдеггером предмета и специфики познавательных средств истории в перспективе предложенной им метафизики конечности. Показано, что обращение к этому проблемному полю явилось результатом его размышлений над взаимосвязью основоположений фундаментальной онтологии с обоснованием предмета и способа постижения истории. Учение Хайдеггера в этом ракурсе сопряжено, как показано в статье, с интенсивным диалогом с идеями В. Дильтея и Ф. Ницше. Дильтей является автором, позволившим Хайдеггеру переосмыслить в экзистенциальном ключе не только историчность Dasein, но и такие феномены как понимание и интерпретация, изначальная открытость смысла исторической традиции. Однако в отличие от Дильтея, утверждавшего плюрализм культурных миров и не принимавшего возможности их рассмотрения в горизонте диахронного единства, Хайдеггер полагал, что герменевтическая перспектива не является препятствием к поиску глобального смысла всемирной истории. Заимствуя у Ницше генеалогическую методологию, он критически пересматривая его видение истории сквозь призму становления нигилизма как забвения жизни. Всемирная история и современный культурный кризис, по его мнению, обретают объяснение в свете разработанного им видения нигилистического забвения Бытия, порожденного европейской метафизической традицией, завершением которой выступает метафизика воли Ницше.

The article is focused on M. Heidegger's analysis of the field and the cognitive means of history in the perspective of the metaphysics of finiteness proposed by him. It reveals that the appeal to this problem field was the result of his reflections on the relationship of the basic principles of fundamental ontology with the substantiation of the subject area and strategy of comprehending history. Heidegger's teaching in this perspective is associated with an intensive dialogue with the ideas of W. Dilthey and F. Nietzsche. Dilthey is the author who allowed Heidegger to rethink in an existential way not only the historicity of Dasein, but also such phenomena as understanding and interpretation, the initial openness of the meaning of historical tradition. However, unlike Dilthey, who argued for the pluralism of cultural worlds and did not accept the possibility of considering them in the horizon of diachronic unity, Heidegger believed that the hermeneutic perspective is not an obstacle to the search for the global meaning of world history. Borrowing the genealogical methodology from Nietzsche, he critically revised his vision of history through the prism of the formation of nihilism as the oblivion of life. World history and the contemporary cultural crisis, in his opinion, find an explanation in the light of the nihilist forgetfulness of Being generated by the European metaphysical tradition, the completion of which is the Nietzschean metaphysics of will.
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling
Authors: Schwarz Jennifer J , Grundmann Lorenz , Kokot Thomas , Kläsener Kathrin , Fotteler Sandra , Medgyesi David , Köhn Maja , Reth Michael , Warscheid Bettina
Published: September 2021

B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. Here, we used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a protein tyrosine phosphatase profiling revealed a high expression of the protein tyrosine phosphatase 1B (PTP1B) in Ramos and human naïve B cells. The loss of PTP1B leads to increased B cell activation. Through substrate trapping in combination with quantitative mass spectrometry, we identified 22 putative substrates or interactors of PTP1B. We validated Igα, CD22, PLCγ1/2, CBL, BCAP, and APLP2 as specific substrates of PTP1B in Ramos B cells. The tyrosine kinase BTK and the two adaptor proteins GRB2 and VAV1 were identified as direct binding partners and potential substrates of PTP1B. We showed that PTP1B dephosphorylates the inhibitory receptor protein CD22 at phosphotyrosine 807. We conclude that PTP1B negatively modulates BCR signaling by dephosphorylating distinct phosphotyrosines in B cell-specific receptor proteins and various downstream signaling components.
Comparison of Virgin Coconut Oil with 5% Amlexanox in Management of Minor Recurrent Aphthous Ulcers - A Randomized Control Trial
Authors: Ravindran Nambiar Dr. Kavitha , R Dr. Krupashankar , S N Dr. Veena , Vijay Dr. Neha , A P Dr. Kavitha
Published: September 2021

Objective: Recurrent Aphthous Ulcer (RAU) is a common (75-80%) painful inflammatory ulcerative disorder of the non-keratinized oral mucosa. Wide range of antiseptics, anti-inflammatory, antibiotics and corticosteroids are available for treatment. Amlexanox is a topical anti-inflammatory and anti-allergic drug used to treat RAS. Recently, there has been increase in interest in use of essential oil and herbal medicine in managing RAU, one such natural product is virgin coconut oil. This study is aimed to determine the efficacy of VCO in management of signs and symptoms of minor recurrent aphthous ulcers. Methodology: 40 patients were included for the study who were randomly divided into two groups. 20 patients in Group A (VCO) and 20 patients in Group B (5%Amlexanox). Primary outcome measured were reduction in ulcer size (in mm) and pain (VAS 1-10). Results: There is high statistical significant difference within the groups in ulcer healing and pain reduction (p=0.00) on 3rd and 5th day. In group A significant reduction in pain was present on the 5th day (p=0.02) and no significant reduction in ulcer size (p=0.083). No adverse effects were reported in either group. Conclusion: VCO could be used as an effective and safe drug in managing the signs and symptoms of RAS. It is edible oil with no known adverse effects and could be a safe therapeutic alternative in children and pregnant women.
Comparative Evaluation of Salivary Cortisol Levels and Peripheral Blood Neutrophil Functions in Chronic Periodontitis Patients with and without Stress – A Case Control Study
Authors: nil Sachin , AM Savita , S Sunil , MA Tejashwini , Naik Archana , Nanaiah K Pallavi
Published: September 2021

Background and aim: Development of chronic periodontitis (CP) is related to the presence of periopathogenic bacteria and several other conditions including stress. In the successful management of chronic periodontitis, early detection of psychological stress plays a crucial role. Salivary cortisol is found to be associated with stress, however not many published evidence exists suggesting the association of stress and salivary cortisol levels in chronic periodontitis. Hence, this study was carried out with the aim to assess salivary cortisol levels and neutrophil functions in chronic periodontitis patients with and without stress. Materials and methods: Cortisol levels were determined using ELISA method from saliva samples collected, analysis of neutrophil functions such as chemotaxis, phagocytosis and intracellular killing was done using nitro blue tetrazolium (NBT) assay, and stress was assessed using Derogatis Stress Profile scale in 60 participants. Study participants were categorized into two groups based on their periodontal condition, Group I: Healthy control (n=30) and Group II: Chronic periodontitis (CP) (n=30) with a probing depth of ≥ 4mm and Clinical attachment loss (CAL) AL >1mm. Results: The difference in mean stress score of the chronic periodontitis group (0.52 ± 0.12) and healthy control group (0.46 ± 0.08) was statistically significant (P < 0.05). Salivary cortisol levels in the healthy (7.77 ± 5.48) and chronic periodontitis (8.77 ± 8.75) groups did not differ significantly. Neutrophil functions defects in the CP group (32.70 ± 12.15) and healthy group (20.33 ± 10.17) differed in a statistically significant manner. Conclusion: Statistically significant differences were observed in the stress levels, salivary cortisol levels and neutrophil functions between healthy and CP subjects with and without stress, thus demonstrating a possible link between CP and stress.
The Relationship Between Information and Communication Technology (ICT), International Migration and Economic Growth in Turkey
Authors: ARİ Yilmaz Onur
Published: September 2021

The paper examines the information and communication technology-international migration-economic growth nexus for Turkish economy using annual time series data covering the period of (1998-2019). Toda-Yamamoto Causality Test (TY) was used in the application of econometric method The results obtained indicated that there is a unidirectional causality from international migration to economic growth in the long run for Turkey. This is inline with the empirical evidences that external immigrant movements can promote economic growth in receiving country. Although the form of migration to Turkey is unclear in terms of skilled or unqualified labor force, international migrants, even including daytripper workers from neighbour countries, boost the economic activities especially in agriculture, construction and service sectors in Turkey. The paper also concluded that there is a one-way causal relationship between ICT and economic growth. The ICT usage can make a substantial contribution to economic growth of Turkey so Turkish government should improve the infrastructure of Internet and mobile phone with a conscious policy initiative. Besides, lastly, it is observed that there is not a causal relationship between migration and ICT at 5 % for Turkey. It’s found that there is a unidirectional causality from migration to ICT at 10 %.
Sağlık alanında çalışan kadınlar ile sağlık alanı dışındaki kadınların coronavirüs-19 fobisinin karşılaştırılması
Authors: KARKIN Pakize Özge , SEZER Gözde , ŞEN Selma , DURAN Müberra
Published: September 2021

Özet

Amaç: Çalışmamızın amacı, Demirci ilçesinde sağlık alanında çalışan kadınlar ile sağlık sektörü dışındaki kadınların coronafobi açısından kıyaslanması ve korku düzeyinin COVID-19 bilinci ile ilişkisini belirlemektir.

Gereç ve yöntem: Tanımlayıcı ve kesitsel olarak planlanan araştırma Demirci ilçesinde Ağustos 2020 tarihinde sağlık kuruluşlarına başvurmuş 365 gönüllü kadın ile yine aynı ilçede sağlık kuruluşlarında çalışan 130 gönüllü kadın ile yürütülmüştür. Verilerin toplanmasında araştırmacılar tarafından oluşturulan sosyodemografik özellikler ve COVID-19 fobisi ölçeğini içeren anket formu kullanılmıştır.

Bulgular: Araştırmaya sağlık personeli olan 130 kadın ve sağlık sektörü dışında olan 365 kadın katıldı. Sağlık personeli olan kadınların ve sağlık sektörü dışında kalan kadınların COVID-19 Fobisi ölçeği toplam puan ortalamaları sırasıyla 55,66±14,71 ve 52,39±16,24 olarak bulunup aralarında istatistiksel olarak anlamlı bir fark olduğu saptandı (p
Evaluating The Impact Of The Covid-19 Outbreak On Healthcare Professionals
Authors: DEMİRKOL Muhammed Emin , KAYA Musa , KÜÇAN Olgu , KOCADAĞ Derya
Published: September 2021

Aim: Covid-19, which emerged in China in the last days of 2019 has spread to the whole world primarily affecting health-care professionals who fight on the forefront against the outbreak. In this study, we aimed to determine depression prevalence among health-care professionals who represent the riskiest group for Covid-19 and its secondary problems.
Methods: The study is a cross-sectional study consisting of health-care staff working in emergency ambulance service of Bolu. A total of 262 subjects was included in the study.
Results: The mean age of the subjects in the study was 31.50±7.19, the youngest participant was 20 and the oldest was 58 years old. 54.4% of the participants were male, 45.6% were female. Among the participants 11.9% had mild depression and 13,7% moderate depression. The rate of those who suffered from severe depression was found to be only 1.8%. Female gender and co-existing chronic diseases seemed to be risk factors for occurrence of depression.
Conclusion: During the on-going Covid-19 outbreak, health-care workers are at risk for infection as well as psychiatric problems such as depression.