bluuebunny/crossref_metadata_2025 huggingface dataset:
Accuracy Enhancement of LIBS-XRF Coal Quality Analysis Through Spectral Intensity Correction and Piecewise Modeling
Authors: Bai Yu , Li Jiaxuan , Zhang Wanfei , Zhang Lei , Hou Jiajia , Zhao Yang , Chen Fei , Wang Shuqing , Wang Gang , Ma Xiaofei , Liu Zhenrong , Luo Xuebin , Yin Wangbao , Jia Suotang
Published: January 2022

The combination of laser-induced breakdown spectroscopy and energy dispersive X-ray fluorescence spectroscopy in the coal quality analysis was reported formerly. But in the practical test of the prototype instrument in the real power plant, the X-ray fluorescence signals suffered from intensity fluctuations over long-time measurements. The long-term signal fluctuations cause lower efficiency on the establishment of the calibration model and relatively larger root-mean-squared error of prediction (RMSEP) for unknown samples. Therefore, the spectral intensity correction was performed in the measurements; a randomly selected sample was measured several times in the whole measurements, including the modeling samples and unknown samples, recording the signal fluctuations and searching for a set of factors suitable for the intensity correction of a full-spectrum–based partial least square calibration model. In addition, as the signals of the coal samples of the power plant showed the potential of classification, the piecewise models were also established in case of further enhancement of the model or prediction accuracy. The RMSEPs of the calorific value, ash, volatile, and sulfur were lowered from 0.68 MJ/kg, 1.62%, 0.32%, and 0.24% to 0.51 MJ/kg, 1.34%, 0.16%, and 0.14% after spectral intensity correction, respectively. The piecewise modeling with spectral intensity correction achieved similar RMSEP for volatile and sulfur prediction but with more accurate models. The spectral intensity correction showed the ability to reduce the long-term signal fluctuation, and piecewise modeling also showed more efficiency in the model establishments for volatile and ash determination.
Assisted Oocyte Activation With Calcium Ionophore Improves Pregnancy Outcomes and Offspring Safety in Infertile Patients: A Systematic Review and Meta-Analysis
Authors: Shan Yinghua , Zhao Huishan , Zhao Dongmei , Wang Jianhua , Cui Yuanqing , Bao Hongchu
Published: January 2022

This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted oocyte activation (AOA). This meta-analysis contained randomized controlled trials and prospective observational and retrospective trials. The summary odds ratio (OR) with 95% confidence intervals (CIs) was calculated for clinical pregnancy rate and live birth rate. Both fixed and random effects models were applied. A total of 22 studies were included into this meta-analysis. Seventeen of the included studies showed that calcium ionophore increased the clinical pregnancy rate (OR, 2.14; 95% CI, 1.38–3.31). Similarly, 14 studies indicated that AOA with calcium ionophore during intracytoplasmic sperm injection (ICSI) improved the live birth rate considerably (OR, 2.65; 95% CI, 1.53–4.60). Moreover, fertilization, blastocyst formation, and implantation rate were higher after using AOA with calcium ionophore combined with ICSI. In addition, calcium ionophore did not increase top-quality embryo rate, cleavage rate, miscarriage rate, congenital birth defects, and neonatal sex ratio. Therefore, calcium ionophore followed by ICSI not only significantly improved live birth and overall pregnancy, but also did not affect the incidence of miscarriage, congenital birth defects, and neonatal sex ratio. This meta-analysis indicated that using calcium ionophore to activate oocytes was beneficial for couples with poor fertilization rates following ICSI.
Climbing-Specific Exercise Tests: Energy System Contributions and Relationships With Sport Performance
Authors: Maciejczyk Marcin , Michailov Michail Lubomirov , Wiecek Magdalena , Szymura Jadwiga , Rokowski Robert , Szygula Zbigniew , Beneke Ralph
Published: January 2022

Purpose

The aim of the study was to evaluate distinct performance indicators and energy system contributions in 3 different, new sport-specific finger flexor muscle exercise tests.

Methods

The tests included the maximal strength test, the all-out test (30 s) as well as the continuous and intermittent muscle endurance test at an intensity equaling 60% of maximal force, which were performed until target force could not be maintained. Gas exchange and blood lactate were measured in 13 experienced climbers during, as well as pre and post the test. The energy contribution (anaerobic alactic, anaerobic lactic, and aerobic) was determined for each test.

Results

The contribution of aerobic metabolism was highest during the intermittent test (59.9 ± 12.0%). During continuous exercise, this was 28.1 ± 15.6%, and in the all-out test, this was 19.4 ± 8.1%. The contribution of anaerobic alactic energy was 27.2 ± 10.0% (intermittent), 54.2 ± 18.3% (continuous), and 62.4 ± 11.3% (all-out), while anaerobic lactic contribution equaled 12.9 ± 6.4, 17.7 ± 8.9, and 18.2 ± 9.9%, respectively.

Conclusion

The combined analysis of performance predictors and metabolic profiles of the climbing test battery indicated that not only maximal grip force, but also all-out isometric contractions are equally decisive physical performance indices of climbing performance. Maximal grip force reflects maximal anaerobic power, while all-out average force and force time integral of constant isometric contraction at 60% of maximal force are functional measures of anaerobic capacity. Aerobic energy demand for the intermittent exercise is dominated aerobic re-phosphorylation of high-energy phosphates. The force-time integral from the intermittent test was not decisive for climbing performance.
Physiological, Biochemical, and Root Proteome Networks Revealed New Insights Into Salt Tolerance Mechanisms in Pongamia pinnata (L.) Pierre
Authors: Marriboina Sureshbabu , Sekhar Kalva Madhana , Subramanyam Rajagopal , Reddy Attipalli Ramachandra
Published: January 2022

Cultivation of potential biofuel tree species such as Pongamia pinnata would rehabilitate saline marginal lands toward economic gains. We carried out a physiological, biochemical, and proteomic analysis to identify key regulatory responses which are associated with salt tolerance mechanisms at the shoot and root levels. Pongamia seedlings were grown at 300 and 500 mM NaCl (∼3% NaCl; sea saline equivalent) concentrations for 15 and 30 days, gas exchange measurements including leaf net photosynthetic rate (Asat), stomatal conductance (gs), and transpiration rate (E), and varying chlorophyll a fluorescence kinetics were recorded. The whole root proteome was quantified using the free-labeled nanoLC-MS/MS technique to investigate crucial proteins involved in signaling pathways associated with salt tolerance. Pongamia showed no visible salt-induced morphological symptoms. However, Pongamia showed about 50% decline in gas exchange parameters including Asat, E, and gs 15 and 30 days after salt treatment (DAS). The maximum potential quantum efficiency of photosystem (PS) II (Fv/Fm) was maintained at approximately 0.8 in salt-treated plants. The thermal component of PSII (DIo) was increased by 1.6-fold in the salt-treated plants. A total of 1,062 protein species were identified with 130 commonly abundant protein species. Our results also elucidate high abundance of protein species related to flavonoid biosynthesis, seed storage protein species, and carbohydrate metabolism under salt stress. Overall, these analyses suggest that Pongamia exhibited sustained leaf morphology by lowering net photosynthetic rates and emitting most of its light energy as heat. Our root proteomic results indicated that these protein species were most likely recruited from secondary and anaerobic metabolism, which could provide defense for roots against Na+ toxicity under salt stress conditions.
Soybean Hypocotyls Prevent Calonectria ilicicola Invasion by Multi-Layered Defenses
Authors: Kobayashi Michie , Win Khin Thuzar , Jiang Chang-Jie
Published: January 2022

In plants, many pathogens infect a specific set of host organs to cause disease, yet the underlying mechanisms remain unclear. Here, we show that inoculation of soybean plants with Calonectria ilicicola, the soil-borne causal agent of soybean red crown rot, caused typical disease symptoms of root rot and leaf chlorosis and necrosis. However, the pathogen DNA was only detected in the roots and stem (hypocotyl) base but not other aerial parts of the plants. As we observed vigorous fungal growth in all culture media made of extracts from roots, stems, and leaves, differences in key components including available nutrients did not determine organ-specific infection and reproduction by C. ilicicola. Furthermore, inoculation of stems both with and without a surface wound showed that the stems resisted C. ilicicola infection via both the pre- and post-invasion defense layers. Transcriptomic comparison of roots and stems using RNA-seq analysis further revealed that upon C. ilicicola inoculation, a greater expression of genes involved in stress response was induced in the plant stems, including receptor-like kinase, AP2/ERF, MYB, and WRKY. In addition, pathways related to amino acid metabolism were also more upregulated in the stems in response to C. ilicicola infection. These results suggest that soybean stems provide C. ilicicola resistance, at least in part, by activating an organ-specific defense response.
Effect of Encoding on Prospective Memory
Authors: Chen Youzhen , Zhang Manman , Xin Cong , Guo Yunfei , Lin Qin , Ma Zhujun , Hu Jinhui , Huang Weiting , Liao Qianfang
Published: January 2022

Event-based prospective memory (ProM) refers to remembering to execute planned actions in response to a target ProM cues. Encoding modality influences ProM performance; visual encoding has been studied more than auditory encoding. Further, it has not yet been examined whether different encoding may influence ProM performance in different encoding modalities. This study examines the effects of encoding modality (visual vs. auditory), cue-encoding specificity (specific cue vs. non-specific cue), and encoding modes (standard vs. implementation intention) on event-based ProM tasks. In Experiment 1, cue specificity and encoding modality were manipulated as a within-groups encoding of visual cues is more commonly and between-groups variable. Results revealed the facilitative effect of cue specificity on ProM performance. Also, with respect to encoding modality, participants showed better performance when receiving auditory instructions compared with the visual encoding condition. In Experiment 2, as in Experiment 1, cue specificity and encoding modality were manipulated. Encoding mode was added as a new between-group variable. Result revealed that there was a significant interaction between encoding modality and encoding modes. Visual implementation intention encoding was a more effective method for improving ProM performance compared with visual standard encoding. Furthermore, there was a significant interaction between cue-encoding specificity and encoding modes. Implementation intention encoding enhances ProM performance in non-specific cue-encoding conditions. Overall, the present study found that (1) auditory encoding modality showed superior ProM performance compared with visual encoding, although implementation intention had facilitative on ProM performance regardless of the encoding modalities, and (2) there was better ProM performance under specific encoding compared with non-specific encoding, and implementation intention had a facilitative effect on ProM performance in the non-specific condition.
Organizational and Job Resources on Employees’ Job Insecurity During the First Wave of COVID-19: The Mediating Effect of Work Engagement
Authors: Vieira dos Santos Joana , Gonçalves Sónia P. , Silva Isabel S. , Veloso Ana , Moura Rita , Brandão Catarina
Published: January 2022

The world of work has been severely affected by the COVID-19 pandemic due to the high instability observed in the labor market, bringing several new challenges for leaders and employees. The present study aims to analyze the role of organizational and job resources in predicting employees’ job insecurity during the first wave of the COVID-19 outbreak, through the mediating role of work engagement. A sample of 207 Portuguese employees participated (Mean age = 45 years old, SD = 9.92), of which 64.7% were women. Data was collected using an online survey, including self-report measures of organizational resources (perceived organizational support), job resources (performance feedback and job autonomy), job insecurity, and work engagement. Data showed that job and organizational resources negatively influenced job insecurity. Moreover, work engagement was a significant mediator of the relation between performance feedback (facet of job resources) and job insecurity. Findings suggest that investing in job and organizational resources can act as protective factors to minimize feelings of job insecurity. Likewise, leaders should foster work engagement among employees to help them balance the relation between these resources and job insecurity, especially in crisis situations. Overall, this study takes a new, underexplored perspective, theoretically bridging organizational and job resources with job insecurity and work engagement during a time of great uncertainty, such as the COVID-19 pandemic.
The Application of Hypnosis in Sports
Authors: Li Zhe , Li Su-Xia
Published: January 2022

As an ancient science, hypnosis has been used by humans since the primitive societies during theocratic times. By the 20th century, scientists and psychologists had re-recognized and studied hypnosis and explored its applications in fields such as medicine, education, and military uses. A local form of traditional Chinese “hypnosis” appeared inHuangdi Neijing, but it has not received enough attention from Chinese people; China’s modern hypnosis development is later than that of American and European countries. Therefore, people’s understanding and applications of hypnosis remain inadequate. With the development of China’s economy and state power in the last decades, Chinese people were beginning to attach importance to the investment and development of the sports industry and realized that the psychological quality of the athletes is often a decisive factor in the success or failure of the competition. Meanwhile, hypnosis is an effective psychological training method to be used in daily training and competitions. In light of this, this essay firstly reviews the history of hypnosis before carrying out the methods of a literature review and a logical analysis to explore the applications of hypnosis in sports. Thus, evidence is provided in favor of the use of hypnosis in the sports industry.
Home Advantage Perceptions in Elite Handball: A Comparison Among Fans, Athletes, Coaches, and Officials
Authors: Gershgoren Lael , Levental Orr , Basevitch Itay
Published: January 2022

Home advantage in sports has been extensively researched in the academic literature over the past five decades. A review of the literature reveals several factors that consistently underly this phenomenon. One of the most documented is the home crowd effect. While the crowd effect on the results has been widely researched considering noise, size, and density, there are conflicting findings of the effect and its extent. Furthermore, the perceptions of fans, athletes, coaches, and officials of the causes of home advantage in general and the crowd effect in particular, remain marginal. This is especially important in the face of significant regulation changes in the stands caused by the COVID-19 pandemic. The current study, therefore, examined the perceptions of fans, athletes, coaches, and officials of the Israeli handball premier league regarding fans’ contribution to the home advantage phenomenon along with other factors (e.g., travel and officiating). A questionnaire examining perceptions regarding home advantage was distributed to 232 Israeli participants (117 fans, 59 players, 26 coaches, and 30 officials). Results, based on MANOVA, ANOVA, and post-hoc analyses, indicated significant differences in participants’ perceptions of the different factors in general and the crowd factor in particular. Overall, the crowd was perceived as the most important factor contributing to the home advantage phenomenon (M = 5.7). Furthermore, fans perceived their contribution (i.e., the crowd) significantly higher than the rest of the participants (p = 0.001; i.e., players, coaches, and officials). On the other hand, officials ranked their contribution to the home advantage effect as low as well as significantly under ranked their contribution in comparison to the other groups (p < 0.001). This result suggests that officials perceive themselves as relatively robust to the crowd effect compared to the other participants. Additional results are discussed in light of existing gaps in the literature on the home advantage phenomenon. Alongside the theoretical contribution, these findings contribute to applied implications of increasing the home advantage effect when playing at home and negating the home advantage when playing away.
Examining the Impact of School Esports Program Participation on Student Health and Psychological Development
Authors: Trotter Michael G. , Coulter Tristan J. , Davis Paul A. , Poulus Dylan R. , Polman Remco
Published: January 2022

This study examined the influence of 7 high school esports developmental programs on student self-regulation, growth mindset, positive youth development (PYD), perceived general health and physical activity (PA), and sport behaviour. A total of 188 students (male n = 120; female n = 68) originally participated (89 enrolled in an esports program in their school and 99 acted as aged-matched controls), with 58 participants (n = 19 esports group; n = 39 controls) completing both pre- and post-program information. At baseline, no significant differences were found between youth e-athletes and their aged-matched controls. The analysis for the observation period showed a significant interaction effect for the PYD confidence scale, with post-hoc comparisons showing a significant decrease in the control group from pre- to post assessment whereas the esports group remained the same. Time main effects showed a decrease in the self-regulation motivation factor, PYD connection factor and PA for all participants. Overall, this study showed that students enrolled in their respective school esports program did not differ from those who did not in self-regulation, growth mindset, PYD, perceived health and PA, and sport behaviour. It was likely that all participants showed a decrease in motivation, connection, and PA due to COVID19 lockdown during the study period. This study is the first to investigate the longitudinal impact of student involvement in high school esports and showed that esports participation did not have a negative impact on any health or psychological factors.
Reported Cases of Serotonin Syndrome in MDMA Users in FAERS Database
Authors: Makunts Tigran , Jerome Lisa , Abagyan Ruben , de Boer Alberdina
Published: January 2022

3,4-Methylenedioxymethamphetamine (MDMA), is investigated as a treatment for post-traumatic stress disorder and other anxiety-related conditions in multiple placebo-controlled and open label studies. MDMA-assisted therapy is projected for approval by the United States Food and Drug Administration (FDA) and other regulatory agencies worldwide within the next few years. MDMA is a monoamine releaser and uptake inhibitor affecting serotonin, potentially increasing the risk of serotonin syndrome (SS). No instances of SS have occurred in clinical trials. The relatively small number of patients in controlled trials warranted a survey of FDA Adverse Event Reporting System data for the occurrence of SS in a larger database. We found 20 SS cases in people exposed to MDMA, all of which had also taken one or more substances with serotonergic properties in addition to MDMA, including amphetamines, stimulants, and opioids. There were no cases of SS associated with MDMA where MDMA was the sole reported compound taken.
Effect of Cold Spells and Their Different Definitions on Mortality in Shenzhen, China
Authors: Meng Chengzhen , Ke Fang , Xiao Yao , Huang Suli , Duan Yanran , Liu Gang , Yu Shuyuan , Fu Yingbin , Peng Ji , Cheng Jinquan , Yin Ping
Published: January 2022

A high premium has been put on researching the effects of cold spells because of their adverse influence on people's daily lives and health. The study aimed to find the most appropriate definition of the cold spell in Shenzhen and quantify the impact of cold spells on mortality. Based on the daily mortality data in Shenzhen from 2013 to 2017 and the meteorological and pollutant data from the same period, we quantified the effect of cold spells using eight different definitions in the framework of a distributed lag non-linear model with a quasi-Poisson distribution. In Shenzhen, low temperatures increase the risk of death more significantly than high temperatures (using the optimal temperature as the cut-off value). Comparing the quasi-Akaike information criterion value, attribution fraction (b-AF), and attribution number (b-AN) for all causes of deaths and non-accidental deaths, the optimal definition of the cold spell was defined as the threshold was 3rd percentile of the daily average temperature and duration for 3 or more consecutive days (all causes: b-AF = 2.31% [1.01–3.50%], b-AN = 650; non-accidental: b-AF = 1.92% [0.57–3.17%], b-AN = 471). For cardiovascular deaths, the best definition was the temperature threshold as the 3rd percentile of the daily average temperature with a duration of 4 consecutive days (cardiovascular: b-AF = 1.37% [0.05–2.51%], b-AN = 142). Based on the best definition in the model, mortality risk increased in cold spells, with a statistically significant lag effect occurring as early as the 4th day and the effect of a single day lasting for 6 days. The maximum cumulative effect occurred on the 14th day (all-cause: RR = 1.54 [95% CI, 1.20–1.98]; non-accidental: RR = 1.43 [95% CI, 1.11–1.84]; cardiovascular: RR = 1.58 [95% CI, 1.00–2.48]). The elderly and females were more susceptible to cold spells. Cold spells and their definitions were associated with an increased risk of death. The findings of this research provide information for establishing an early warning system, developing preventive measures, and protecting susceptible populations.
Keep Calm and Do Not Carry-Forward: Toward Sensor-Data Driven AI Agent to Enhance Human Learning
Authors: Sharma Kshitij , Lee-Cultura Serena , Giannakos Michail
Published: January 2022

The integration of Multimodal Data (MMD) and embodied learning systems (such as Motion Based Educational Games, MBEG), can help learning researchers to better understand the synergy between students' interactions and their learning experiences. Unfolding the dynamics behind this important synergy can lead to the design of intelligent agents which leverage students' movements and support their learning. However, real-time use of student-generated MMD derived from their interactions with embodied learning systems (MBEG in our case) is challenging and remains under-explored due to its complexity (e.g., handle sensor-data and enable an AI agent to use them). To bridge this gap, we conducted an in-situ study where 40 children, aged 9–12, played MBEG on maths and language development. We automatically, unobtrusively, and continuously monitored students' experiences using eye-tracking glasses, physiological wristbands, and Kinect, during game-play. This allowed us to understand the different cognitive and physiological dimensions of students' progress (right/wrong responses) during the three different stages of the MBEG problem-solving processes, namely the “see-solve-move-respond” (S2MR) cycle. We introduce the novel Carry Forward Effect (CFE); a phenomenon occurring in such games, whereby students propagate, or “carry forward,” the cognitive and physiological effects derived from their MMD, to subsequent phases in the see-solve-move-respond cycle. By identifying moments when the Carry Forward Effect is congruent (or not) to students' learning performance, we uncover opportunities for feedback delivery to encourage or subdue the impact of the CFE. Our results demonstrate the importance of wristband and eye-tracking data as key indicators for prioritizing adaptive feedback to support students in MBEG and emphasize the significance of using MMD to support students' performance in real-time educational settings.
Sick or Sad? A Qualitative Study on How Dutch GPs Deal With Sadness Complaints Among Young Adults
Authors: van Dijk Eva L. , van Tol Donald G. , Diemers Agnes D. , Wienen Albert W. , Batstra Laura
Published: January 2022

Feelings of sadness among young adults related to a certain phase of life or to societal factors run the risk of being interpreted as an individual medical problem. Therefore, healthcare professionals should more often widen their perspective and consider de-medicalization as being part of their professional responsibility too. This article presents results from a qualitative interview conducted with 13 GPs in different phases of their career to get more insight into the way they deal with complaints of sadness among young adults. All participants acted proactively but in different ways. Based on the interviews, a typology of three types of general practitioners has been created: the fast referrer, the expert, and the societal GP. There seems to be a paradox in the way GPs think about de-medicalization on a macro level and the way they act on a micro level. Elaborating on Parsons’(1951) classical concept of the sick role, this study introduces the term semi-legitimized sick role to clarify this paradox. The third type, “the societal GP”, appears to be the most able to show a more multifactorial view on complaints of sadness. Therefore, this type connects the most to a course of de-medicalization.
Case Report: Kasai Operation in Biliary Atresia After Extensive Bowel Resection
Authors: Chen Szu-Han , Chang Kai-Chi , Wu Jia-Feng , Chen Huey-Ling , Lin Wen-Hsi
Published: January 2022

Biliary atresia (BA) is a major and devastating cholestatic liver disease in infancy. The Kasai procedure is an operation to re-establish bile flow from the liver into the intestine that can prevent the young infant from progressing rapidly to cirrhosis. The standard Kasai procedure includes the removal of extrahepatic bile duct remnants and reconstruction. We report a case of BA with short bowel due to previous small intestinal volvulus. This full-term female infant received extensive small bowel resection after birth due to intestinal volvulus. The length of the residual small bowel was 55 cm with an intact ileocecal valve. Because of progressive cholestasis and clay stool, another laparotomy was performed under the diagnosis of BA on the 52 days old. After dissection of the hepatic portal area, a segment of the colon instead of intestine was used as a biliary conduit to avoid further shortening her small bowel. The patient recovered from the procedure uneventfully and the parenteral nutrition was discontinued 2 weeks later. Two episodes of cholangitis happened after discharge. She gradually resumed body weight gain and the bilirubin level returned to normal range 6 months after the operation. This unique case demonstrated successful use of this specific procedure in the patient with BA and short bowel that have never been reported in the literature.
Impact on Quality of Life of Seton Placing in Perianal Crohn's Disease
Authors: Angriman Imerio , Tomassi Monica , Ruffolo Cesare , Bordignon Giovanni , Saadeh Luca , Gruppo Mario , Pucciarelli Salvatore , Bardini Romeo , Scarpa Marco
Published: January 2022

Introduction

Often, in perineal Crohn's disease (CD), a seton is placed to guarantee a constant drainage and prevent septic complication while biologic therapy is ongoing. This study aimed to assess the long-term quality of life after surgery for perineal CD in relation to seton placing.

Patients and Methods

Data of 65 consecutive patients with CD and non-CD operated on from 2014 to 2019 for perianal fistula or abscess were retrieved. Forty-three had CD and 14 of them had a seton placed during surgery and they kept it on while they had anti-TNF-alpha therapy. Patients were interviewed with the Cleveland Global Quality of Life (CGQL) and SF-12 quality of life questionnaires. Disease activity was defined as Harvey-Bradshaw Index (HBI) and Perianal Disease Activity Index (PDAI). Comparisons between groups were carried out with the nonparametric tests, and multiple regression models were used to assess predictors of quality of life.

Results

The total CGQL score and SF-12 mental component score (MCS) were significantly higher (and thus better) in the seton group than in patients treated without seton. On the contrary, SF-12 physical component score (PCS) was not different between the two groups. HBI was significantly better in patients in the seton group. At multivariate analysis, seton placement and HBI were confirmed to be independent predictors of long-term SF-12 MCS whereas only HBI confirmed to be a predictor of total CGQL score.

Conclusions

Seton placing during anti-TNF-alpha therapy is independently associated with a better MCS. Unexpectedly, this device, instead of to cause psychological distress, seems to assure patients during their biologic therapy providing psychological benefit beyond the mere medical effect.
Incidence and Predictors of Synchronous Bone Metastasis in Newly Diagnosed Differentiated Thyroid Cancer: A Real-World Population-Based Study
Authors: Qi Lin , Zhang Wenchao , Ren Xiaolei , Xu Ruiling , Liu Chaoqian , Tu Chao , Li Zhihong
Published: January 2022

Background

Clinical and sociodemographic characteristics of differentiated thyroid cancer (DTC) patients with synchronous bone metastasis (SBM) remain unclear. This real-world study aimed to elucidate the incidence and prognosis of DTC patients with SBM using population-based data.

Methods

Data of patients with newly diagnosed DTC from 2010 to 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariable logistic regression analysis was utilized to identify predictors of developing SBM in patients with DTC and was further evaluated by receiver operator characteristics (ROC) analysis. Multivariable Cox regression was applied to identify prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS).

Results

A total of 67,176 patients with DTC were screened from the database, with 0.36% (244/67,176) developed SBM. The age-adjusted incidence of SBM in patients with DTC was relatively stable during the study period with an average annual percentage change (AAPC) of 2.52. Multivariable logistic regression analysis recognized seven factors (older age, male gender, black race, other races, follicular histology, the American Joint Committee on Cancer (AJCC) T2, T3, T4 staging, and N1 staging) as predictors of developing SBM among the entire cohort, with the value of area under the curve (AUC) of 0.931 (95% CI: 0.915–0.947). The median survival time of DTC patients with SBM was 22 months (interquartile range, 7–47 months). The multivariable Cox regression analysis indicated multiple metastatic sites, surgical procedures, and chemotherapy as predictors for the survival of patients.

Conclusions

Predictors and prognostic factors of SBM in patients with DTC were identified in this study. Patients with risk factors should be given more attention in clinical practice.
On Farm Emergency Slaughter and Emergency Killing of Acutely Injured Cattle: Analysis of Guidelines From Five Jurisdictions
Authors: McDermott Paul , McKevitt Aideen , Hanlon Alison
Published: January 2022

Background

In July 2009, the Farm Animal Welfare Advisory Council (FAWAC) in the Republic of Ireland published Animal Welfare Guidelines for the Management of Acutely Injured Animals on Farm in support of a new Irish regulation designed to permit on-farm emergency slaughter (OFES) of cattle. The purpose of this study was to evaluate the FAWAC guidelines, to determine if they remain fit for purpose by comparing them with five guidelines on the management of acutely injured cattle from four jurisdictions purposively selected because of their relevance to OFES, and to represent geographical and organisational diversity; The United Kingdom, Australia, New Zealand and British Columbia/Canada.

Methodology

Content and Thematic Analysis were used to compare the incidence and frequency of themes in the six guidelines using NVIVO 12.

Results

Humane killing and slaughter of animals and the prevention of unnecessary suffering at time of killing were emphasised in all guidelines. Thematic Analysis identified seven primary themes (“parent nodes”): animal welfare; decision tree; certification; legislation; stakeholders; transport and; veterinary ethics. Parent nodes encompassed 26 secondary themes (“child nodes”) including casualty slaughter, on-farm emergency slaughter, euthanasia, unnecessary suffering, animal owner, private veterinary practitioner, official veterinarian and fitness for transport. Guidelines outlined stakeholders' roles in relation to all aspects of managing acutely injured cattle. Results showed similarities between FAWAC, the British Cattle Veterinary Association and the British Columbian/Canadian guidelines in relation to OFES as a method to address acutely injured cattle. OFES is not allowed in Australia or New Zealand as a method of managing acutely injured cattle.

Conclusions

Animal welfare guidelines play a pivotal role in informing all stakeholders involved in the management of acutely injured cattle. Guidelines vary from prescriptive standard operating procedures on actions that should be undertaken for food safety reasons, to descriptive guidance upholding practicalities in relation to equipment and methods to be used in managing acutely injured cattle not meant for human consumption. The FAWAC guidelines remain substantially relevant today and consistent with other welfare guidelines published in the jurisdictions that formed part of the study. However, they need to be reviewed to align with current regulations.
Should We Delay the Second COVID-19 Vaccine Dose in Order to Optimize Rollout? A Mathematical Perspective
Authors: Berkane Soulaimane , Harizi Intissar , Tayebi Abdelhamid , Silverman Michael S. , Stranges Saverio
Published: January 2022

Objectives: With vaccination shortage persisting in many countries, adopting an optimal vaccination program is of crucial importance. Given the slow pace of vaccination campaigns globally, a very relevant and burning public health question is whether it is better to delay the second COVID-19 vaccine shot until all priority group people have received at least one shot. Currently, many countries are looking to administer a third dose (booster shot), which raises the question of how to distribute the available daily doses to maximize the effectively vaccinated population.

Methods: We formulate a generalized optimization problem with a total of uT=∑i=1nui vaccine doses, that have to be optimally distributed between n different sub-populations, where sub-population ui represents people receiving the ith dose of the vaccine with efficacy αi. The particular case where n = 2 is solved first, followed by the general case of n dose regimen.

Results: In the case of a two dose regimen, if the efficacy of the second dose is less than (or equal to) twice the efficacy of the first dose, the optimal strategy to maximize the number of effectively vaccinated people is to delay the second vaccine as much as possible. Otherwise, the optimal strategy would consist of administering the second dose as quickly as possible. In the general case, the optimal vaccination strategy would be to administer the k − th dose corresponding to the index providing the maximum inter-dose efficacy difference (αi − αi−1) for all possible values of i ∈ {1, … , n}, with α0 = 0.

Conclusion: Our results suggest that although extending the interval between doses beyond 12 weeks was likely optimal earlier in the pandemic, the reduced single dose efficacy of vaccines against the delta variant make this approach no longer viable.
Converting of Boolean Expression to Linear Equations, Inequalities and QUBO Penalties for Cryptanalysis
Authors: Pakhomchik Aleksey I. , Voloshinov Vladimir V. , Vinokur Valerii M. , Lesovik Gordey B.
Published: January 2022

There exists a wide range of constraint programming (CP) problems defined on Boolean functions depending on binary variables. One of the approaches to solving CP problems is using specific appropriate solvers, e.g., SAT solvers. An alternative is using the generic solvers for mixed-integer linear programming problems (MILP), but they require transforming expressions with Boolean functions to linear equations or inequalities. Here, we present two methods of such a transformation which applies to any Boolean function defined by explicit rules giving values of the Boolean function for all combinations of its Boolean variables. The first method represents the Boolean function as a linear equation in the original binary variables and, possibly, binary ancillaries, which become additional variables of the MILP problem being composed. The second method represents the Boolean function as a set of linear inequalities in the original binary variables and one additional continuous variable (representing the value of the function). The choice between the first or second method is a trade-off between the number of binary variables and number of linear constraints in the emerging MP problem. The advantage of the proposed approach is that both methods reduce important cryptanalysis problems, such as the preimaging of hash functions or breaking symmetric ciphers as the MILP problems, which are solved by the generic MILP solvers. Furthermore, the first method enables to reduce the binary linear equations to quadratic unconstrained binary optimization (QUBO), by the quantum annealer, e.g., D-Wave.
Safe Motion Planning and Learning for Unmanned Aerial Systems
Authors: Perk Baris Eren , Inalhan Gokhan
Published: January 2022

To control unmanned aerial systems, we rarely have a perfect system model. Safe and aggressive planning is also challenging for nonlinear and under-actuated systems. Expert pilots, however, demonstrate maneuvers that are deemed at the edge of plane envelope. Inspired by biological systems, in this paper, we introduce a framework that leverages methods in the field of control theory and reinforcement learning to generate feasible, possibly aggressive, trajectories. For the control policies, Dynamic Movement Primitives (DMPs) imitate pilot-induced primitives, and DMPs are combined in parallel to generate trajectories to reach original or different goal points. The stability properties of DMPs and their overall systems are analyzed using contraction theory. For reinforcement learning, Policy Improvement with Path Integrals (PI2) was used for the maneuvers. The results in this paper show that PI2 updated policies are a feasible and parallel combination of different updated primitives transfer the learning in the contraction regions. Our proposed methodology can be used to imitate, reshape, and improve feasible, possibly aggressive, maneuvers. In addition, we can exploit trajectories generated by optimization methods, such as Model Predictive Control (MPC), and a library of maneuvers can be instantly generated. For application, 3-DOF (degrees of freedom) Helicopter and 2D-UAV (unmanned aerial vehicle) models are utilized to demonstrate the main results.
In-Situ Optical Measurements of Solid and Hybrid-Propellant Combustion Plumes
Authors: Whitmore Stephen A. , Frischkorn Cara I. , Petersen Spencer J.
Published: January 2022

A method for in-situ optical measurements of solid and hybrid propellant rocket plumes is developed, and results from proof of concept tests are presented. The developed method inserts fiber-optic cables acting as radiation conduits into the solid-fuel combustion port, allowing optical signals to be transmitted from the flame zone to externally-mounted spectrometers. Multiple hot-firings using a using a lab-scale gaseous-oxygen, thermo-plastic fueled hybrid rocket system were performed to validate the sensing method. Burn durations varied from 5 to 25 s, and the inserted fiber optic sensors survived for all of the hot fire tests. The obtained optical spectra were curve-fit to Planck’s black-body radiation law, and Wien’s displacement law was used to estimate the internal flame-temperature. Optically-sensed flame-temperatures are correlated to analytical predictions, and shown to generally agree within a few degrees. Additionally, local maxima in the optical spectra are shown to correspond to emission frequencies of atomic and molecular hydrogen, water vapor, and molecular nitrogen; all species known to exist in the hybrid combustion plume. Based on these preliminary test results, it is concluded that this simple in-situ measurement system operates as designed, and it shows considerable promise for future applications to a wide swath of gas-generator systems.
Dynamic Relationship of Urban and Rural Water Shortage Risks Based on the Economy–Society–Environment Perspective
Authors: Yang Yuchen
Published: January 2022

Based on the economy–society–environment perspective, this study details the causes and characteristics of urban and rural water shortage risks, and then explores the dynamic relationship between urban and rural water shortage risks. It quantitatively analyzes the urban and rural water shortage risks of 52 areas in Northwest China during 2001–2019. Furthermore, the dynamic relationships are tested by using the exploratory spatial data analysis model. The main conclusions are as follows: (1) The water shortage risk level is gradually declining over time, while the urban water shortage risk is improving faster than the rural water shortage risk. (2) The relationships show significant synergy. There are four primary types: strong synergy areas, medium synergy areas, weak synergy areas, and very weak synergy areas. (3) The levels of synergy within the northwestern regions show a positive spatial correlation and spatial agglomeration; that is, regions with high levels of synergy are adjacent, while regions with low levels of synergy are adjacent. From the perspective of local spatial differentiation, positive spatial autocorrelation patterns (H-H and L-L) account for a large proportion and gradually increase over the research period, reflecting the patterns of H-H and L-L. The agglomeration becomes increasingly obvious.
A Feeding Quantity Monitoring System for a Combine Harvester: Design and Experiment
Authors: Jiang Tao , Guan Zhuohuai , Li Haitong , Mu Senlin , Wu Chongyou , Zhang Min , Wang Gang , Chen Xu
Published: January 2022

Due to the commitment to the target of green mechanized production and precision agriculture, the operating parameters of the main functional components of a combine harvester need to be adjusted according to the feeding quantity. Therefore, feeding quantity monitoring is one of the key technologies of intelligent control for a combine harvester. In order to obtain the accurate information of feeding quantity in the harvesting operation process in real time, a monitoring system was set up to obtain the accurate information of feeding quantity in real time. The torque signal corresponding to different feeding quantity was obtained through bench calibration experiments. The signal was decomposed, noise reduced, and reconstructed through the analysis of the frequency range of the noise based on the wavelet transform. A fitting relationship between the torque and the feeding quantity was obtained. Field validation experiment results showed good consistency of the measured data and the actual quantity. This paper provides a theoretical basis and technical reference for subsequent research on intelligent control of combine harvesters.
1H NMR Reveals Dynamic Changes of Primary Metabolites in Purple Passion Fruit (Passiflora edulis Sims) Juice during Maturation and Ripening
Authors: Md Nor Shahidah , Ding Phebe , Abas Faridah , Mediani Ahmed
Published: January 2022

Passion fruit (Passiflora edulis Sims) is a tropical fruit that shows an increasing demand from global fresh fruit industries. The fruit is known to have climacteric properties that allow it to achieve ripening during distribution and transportation. However, the metabolic alterations that occur during ripening are poorly understood. Thus, this study was conducted to analyze the metabolites in passion fruit juice at different harvesting stages (35, 42, 49, 56 and 63 days after anthesis), employing 1H NMR spectroscopy combined with chemometric analysis. A total of 30 metabolites were successfully identified using 1H NMR, the majority of which belong to primary metabolites, consisting of 14 amino acids, 7 sugars and 6 organic acids. Nevertheless, only three secondary metabolites were detected. Analyzing the metabolites using multivariate analysis reveals 13 of the metabolites were highly influential metabolites. These primary metabolites play essential roles in the maturation and ripening of fruit. Glycolysis, the tricarboxylic acid (TCA) cycle and the shikimate pathway were differentially regulated during maturation and ripening of passion fruit. Profiling the metabolome of fruit during maturation and ripening reveals that all metabolites are interconnected with each other to cause maturation and ripening in passion fruit. This work will enhance the knowledge of physiological changes in purple passion fruit during maturation and ripening.
AMMI Analysis of the Effects of Different Insecticidal Treatments against Agrotis spp. on the Technological Yield from Sugar Beet
Authors: Bocianowski Jan , Wielkopolan Beata , Jakubowska Magdalena
Published: January 2022

The aim of this study was to analyze the effects of different variants of insecticidal treatment against Agrotis spp. caterpillars on the technological yield from sugar beet using the AMMI (Additive Main Effect and Multiplicative Interaction) model. Data for the analysis of sugar beet yield and different insecticidal treatments were obtained from a trial in Winna Góra between 2011 and 2018. White sugar yield was estimated for each variant of treatment, and it was found to be directly proportional to the root weight and polarization. The content of potassium in molasses had an inversely proportional effect on the sugar yield in the variant of treatment based on phenological observations with calculated heat sums, as well as in controls. The content of α-amino-N had an inversely proportional effect on the technological yield of sugar for each variant of tested chemical treatments. The content of α-amino-N had a statistically significant effect on the sugar beet yield for all tested experimental combinations. AMMI analysis used to estimate the interaction of treatments based on environmental conditions showed the additive effect of the applied treatments on the quality parameters of white sugar yield from sugar beet. These effects were demonstrated for polarization and the content of sodium in molassigenic substances. Regarding the AMMI model, the results of the analysis of variance showed a significant interaction between treatment and year for all considered characteristics in the experiment.