bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN TEKNOLOGI AUGMENTED REALITY DALAM PENJUALAN SEPEDA MOTOR
Authors: Christian Steven , Suryantara I Gusti Ngurah
Published: March 2024

Sepeda motor merupakan kendaraan roda dua yang paling banyak digunakan di indonesia pada saat ini. Sepeda motor banyak digunakan karena harganya yang murah dan biaya operasional yang lebih hemat. Sistem penjualan motor pada saat ini masih menggunakan brosur untuk media penjualannya, akan tetapi cara tersebut dianggap kurang maksimal karena pembeli tidak dapat melihat gambar motor secara keseluruhan. Oleh karena itu, dilakukan penelitian dengan melakukan implementasi teknologi Augmented Reality ke dalam sistem penjualan motor. Dengan menggunakan teknologi Augmented Reality, pembeli hanya melakukan scan pada marker yang ada menggunakan smartphone. Untuk metode yang digunakan dalam penelitian ini adalah Multimedia Development Life Cycle (MDLC). Multimedia Development Life Cycle (MDLC) adalah metode yang digunakan untuk merancang video, gambar, dan animasi. Untuk tahap-tahap yang digunakan pada MDLC adalah tahap Concept, Design, Material Collecting, Assembly, Testing, dan Distribution. Hasil dari penelitian ini adalah aplikasi memanfaatkan teknologi AR berbasis marker-based tracking untuk membuat gambaran motor dan spesifikasinya. Penelitian ini dibangun menggunakan Unity sebagai software pengembangan game dan Vuforia SDK sebagai teknologi AR untuk menampilkan objek dengan marker. Kesimpulan pada penelitian ini adalah aplikasi sistem penjualan sepeda motor dapat menerapkan tahapan MDLC untuk mencapai daur hidup tahapan pengembangan Augmented Reality.
ANALISA PERBANDINGAN TINGKAT EFISIENSI ALGORITMA DATA DEFINITION LANGUAGE COPY, INPLACE, INSTANT DATABASE MYSQL
Authors: Sinata Frans
Published: March 2024

MySQL database schema changes are becoming more frequent than ever, Four out of five application updates (releases) require appropriate database changes, For Database schema changes are more often a repetitive task, it may be a request from the application team to add or modify a column in a table and many cases other. This study aims to measure the level of time efficiency to modify the sales transaction table schema which consists of 50000 number of records in the MySQL database with the Data Definition Language (DDL) Copy, Inplace and Instant algorithm on the MySQL database.
PERANCANGAN VISUALISASI ANIMASI 2D INTERAKTIF SIKLUS PANJANG HIDROLOGI BERBASIS LAZARUS
Authors: Virginia Stella
Published: March 2024

Technological advances have had a positive impact on various aspects, including education and understanding of natural phenomena. One natural phenomenon that is important to understand is the long cycle of the hydrosphere which involves changes in the phase of environmental water. The main goal of this design is to create a visualization that can clearly and comprehensively depict the long cycle of the hydrosphere. The design methods used include literature analysis, user interface design, hydrosphere cycle modeling, and implementation of interactive animation using Lazarus. The data and information needed to produce this animation were collected from trusted sources and verified by experts in the field of hydrology. Users can easily understand various aspects and processes of the hydrosphere cycle through interesting and informative animations. Lazarus, a Free Pascal-based software development environment, because it offers high flexibility and affordability in developing interactive 2D animation rendering applications. The result of this design is an interactive 2D animated visualization application that gives users an idea of how to explore the long cycle of the hydrosphere using interactive controls. Users can see the changes that occur at each stage and monitor the progress of the steps according to their wishes. It is hoped that this visualization will contribute to education and understanding of the hydrospheric cycle and will be a useful tool for teachers and students in interactive learning. Apart from that, the development of this application can be the basis for developing other visualizations related to natural phenomena.

Keywords: 2D animated visualization, interactive, long cycle of the hydrosphere, Lazarus, Education
ANDROID-BASED DEVELOPMENT OF INTERACTIVE MULTIMEDIA LEARNING APPLICATION SYSTEMS FOR CHILDREN
Authors: Krisno Reynaldo , Rarasati Dionisia Bhisetya
Published: March 2024

Technological developments have progressed very rapidly, marked by progress in the field of technology and information. Information technology has now spread to almost all aspects of life, one of which is that it has entered the educational aspect which is used as an interesting learning medium, because it is able to provide new colors in the learning process, and can use a learning while playing approach so that the learning process can feel happy, so that later students are able to express themselves maximally in the learning process. In education there are many things that need to be considered in child development so as to avoid various obstacles in the learning process, such as color blindness, speech delays, and other pre-school abilities by introducing cognitive education to children such as recognition of numbers, letters, colors. And according to IDAI this cognitive recognition period is recommended for children aged 2 -5 years. Researchers developed an Android-based interactive multimedia learning system for children with the aim of providing facilities to parents for children in introducing cognitive aspects with new colors, namely in the form of interactive multimedia applications. The development method used is MDLC (Multimedia Development Life Cycle), because the application being developed involves various media such as sound, images and text. The development of this application also applies quiz content to maximize children's learning media. Through testing using Black Box Testing, the WARUKA Education application that was developed managed to achieve good results. All the features contained in the application run well and as expected. In the User Acceptance Testing test using a questionnaire, the WARUKA Education application gets positive results, with a user satisfaction percentage of 94.167%. Based on this percentage, the WARUKA Education application can be categorized as very good, indicating very high acceptability for users.
La formación de intérpretes de lenguas indígenas para la justicia en México. Sociología de las ausencias y agencia decolonial
Authors: Kleinert Cristina V. , Stallaert Christiane
Published: March 2024

La profesionalización de la interpretación en los servicios públicos en México se está conformando lentamente y muestra gran vitalidad. En este artículo se reflexiona sobre el desarrollo y configuración de este campo en el ámbito de la formación de intérpretes en lenguas indígenas para la justicia penal, con base en datos recogidos en los estados de Veracruz, Puebla y Oaxaca con intérpretes formados durante 2011 y 2012. El estudio se sustenta en datos cualitativos a partir de una etnografía doblemente reflexiva (Dietz 2012) atravesada por una autoetnografía (Scribano 2009). La situación actual del campo se lee desde un enfoque decolonial (Escobar 2003; Rama 1984; Mignolo 2003) y una epistemología intercultural (Santos 2006, 2010). El análisis devela una creciente conciencia y agencia decolonial, si bien todavía incipiente, entre egresados de los diplomados, cuyas influencias se vislumbran en los retos de transformación del campo de la justicia penal.
The Style Parameter in Quality Evaluation and Expectations of Simultaneous Interpreting
Authors: Pérez-Luzardo Díaz Jessica
Published: March 2024

This study focuses on the analysis of the style parameter, which is one of the nine parameters established by Bühler (1986) to evaluate the quality of an interpretation, and its impact on conference interpretations. Three studies have been designed to analyze the replies of a group of specialized users, and how the subjects understand the concept of ‘style’. These studies also show the effect of a manipulation to create an excessively complex style on the recipients of the interpretation, users’ expectations, and the interaction of this parameter with others, both verbal and non-verbal. Although the study indicates the lack of consensus when it comes to a definition of the concept of style, it also shows that its significance may be greater than that which has been attributed to it so far in the field of interpretation.
La interpretación telefónica y su práctica profesional. Estudio de caso sobre dos empresas proveedoras del servicio en España
Authors: Del Pozo Triviño María Isabel , Campillo Rey Lucía
Published: March 2024

La interpretación telefónica es una modalidad que está cada vez más presente en los servicios públicos en España dadas las ventajas que ofrece, entre las que se pueden mencionar: el reducido coste, la disponibilidad inmediata, el anonimato, etc. Como consecuencia de esta mayor presencia en el ámbito profesional, también en los últimos años la interpretación telefónica ha sido objeto de investigaciones y estudios científicos (Rosenberg 2007, Kelly 2008, Fernández Pérez 2012 y 2015, entre otros). En el presente artículo se realiza, en primer lugar, una revisión de la literatura científica centrada en este tema y, posteriormente, un análisis de las pautas profesionales establecidas por las dos principales empresas que ofrecen este servicio en España. Finalmente, se reflexiona sobre el grado de convergencia entre los trazos de la interpretación telefónica que se señalan en la literatura científica revisada y las pautas profesionales establecidas por las empresas analizadas.
La interpretación social y la mediación intercultural en el ámbito escolar. Un estudio exploratorio sobre las necesidades de interpretación en la ciudad de Córdoba
Authors: Ruiz Aurora , Soria Elena
Published: March 2024

Con este trabajo pretendemos mostrar el panorama de la interpretación social y la mediación intercultural en el ámbito escolar en Córdoba. Para ello, establecemos un marco teórico, analizamos la figura de mediador intercultural e intérprete en los centros escolares y recopilamos la regulación vigente. Nuestro estudio exploratorio parte del vacío profesional y escasez de expertos con formación específica contratados en este campo. Para su comprobación, realizamos un estudio con la finalidad de conocer las necesidades lingüísticas del sector educativo primario y los problemas que de él se derivan. Dicho estudio se efectúa mediante una encuesta y entrevistas a directores y otros miembros de ocho centros públicos, pertenecientes a los alrededores del barrio con mayor inmigración (Ciudad Jardín). Los resultados del estudio muestran la ausencia de expertos haciendo que los propios profesores tomen decisiones ante dificultades comunicativas, culturales y lingüísticas a la hora de tratar con familias inmigrantes.
IMPLEMENTASI PENGGUNA QRIS PADA KAUM MILENIAL
Authors: Ardi Muhammad , Astuti Astuti , Aditya Farham
Published: March 2024

Kaum milenial adalah generasi pertama yang tumbuh di era digital. Antusiasme kaum milenial terhadap pembayaran QRIS berkembang pesat. Adapun tujuan penelitian yakni kelebihan dan kekurangan menggunakan QRIS dan  dampak signifikan selama menggunakan QRIS. Penelitian ini  menggunakan metode kualitatif. Informan dalam penelitian ini yakni 3 orang mahasiswa dan 2 orang mahasiswi. Data diperoleh dengan cara interview. Adapun hasil penelitian yakni kemudahan dan kecepatan dalam melakukan pembayaran digital, keamanan transaksi yang lebih baik, memudahkan para merchant atau toko untuk menerima pembayaran dari berbagai jenis aplikasi pembayaran digital tanpa harus memiliki banyak alat pembayaran yang berbeda, dan memungkinkan pengguna untuk mendapatkan berbagai macam promo dan cashback dari aplikasi pembayaran digital yang telah terintegrasi dengan QRIS. Kelemahan yang dirasakan yakni ketergantungan smartphone. QRIS sangat bergantung pada penggunaan smartphone dan konektivitas internet sehingga membatasi jangkauan QRIS sebagai metode pembayaran.Kelemahan yang kedua yakni masalah keamanan.
FACTORS AFFECTING SECOND LANGUAGE COMPREHENSION ABILITY IN CHILDREN: A SYSTEMATIC REVIEW
Authors: Mohd Tahir Asman Bin
Published: March 2024

This systematic review aims to explore the factors that influence children's second language comprehension ability. Second language acquisition in children is a complex process that is influenced by a variety of factors. Understanding these factors can provide valuable insights for educators, parents, and policymakers to optimize language learning strategies and interventions. This review follows a systematic approach by conducting a comprehensive search across multiple databases, including educational, psychological, and linguistic sources. Relevant studies published in the last decade were included in the analysis. The review focuses on children aged 5 to 12 years, as this is a crucial period for language development and acquisition. By combining previous investigations as a more thorough evaluation of the literature, this study used the systematic literature review (SLR) method to address the research issues. The findings reveal several key factors that influence second language comprehension ability in children. Firstly, individual cognitive factors, such as working memory capacity, attention, and executive functions, play an important role in language processing and comprehension. Second, socio-cultural factors, including parental involvement, socioeconomic status, and exposure to a second language in the community, influence language learning outcomes. Thirdly, instructional factors, such as the quality of teaching methods, curriculum design, and classroom environment, have a great impact on children's language comprehension abilities. Based on these findings, this review underscores the need for a comprehensive and holistic approach to improving second language comprehension skills in children. It emphasizes the importance of integrating cognitive, socio-cultural, and instructional factors in language learning programs. In addition, the review also identifies research gaps and provides recommendations for future research to further enhance our understanding of second language acquisition in children.
THE INVESTIGATION OF PRESENT CONTINUOUS TENSE DIFFICULTIES AT NINETH JUNIOR HIGH SCHOOL
Authors: Holifah Agus Regi , Aryadi Mohammad Fajar , Wahono Suparwoto Sapto , Hasanah Uswatun , Sholichah Laily Fadhilatus
Published: March 2024

English learning in Indonesia, especially at the junior high school level has various obstacles. One of these obstacles is that students find it difficult in learning present continuous tense because students think that present continuous tense is similar to present tense. The aimed of this research is to describe students' difficulties in learning present continuous tense. This type of research is descriptive qualitative. The research subjects of this study were 4 students consist of 2 female and 2 male nineth grade students of Al-Fattah Junior High School, Jember The instruments used include observation, interview and document review. The data obtained were analyzed using source triangulation and technique triangulation methods. The results of this study show that students have difficulty in making example sentences using the present continuous tense, difficulty in understanding the meaning of the present continuous tense pattern.
Impact of the Mother's Mental Health and Socioeconomic Status on Prenatal Attachment in a Population-Based Sample of Expectant Romanian Women
Authors: Bernad Brenda Cristiana , Mitrache Dănuța , Hogea Lavinia , Pașcalău Ana , Gavreliuc Alin , Craina Marius , Enătescu Virgil , Ciulpan Adrian-Bogdan , Lăcătușu Adrian , Lungeanu Diana , Bucur Venera , Bernad Elena
Published: March 2024

Background: The health development of a baby during pregnancy is greatly influenced by prenatal bonding. The purpose of this study is to assess maternal-fetal attachment in the second- and third-trimesters and explore how the mother’s mental health and socioeconomic circumstances may affect it. Additionally, this study takes into account other relevant aspects, and addresses the existing lack of relevant information in Romania. Methods: We conducted a cross-sectional study. Data were collected from 200 pregnant women in the second- and third-trimesters of pregnancy. Personal Information Form (PIF), Depression, Anxiety, and Stress Scale-21 (DASS-21), and Maternal-Foetal Attachment Scale (MFAS) questionnaires were collected. Results: There was no statistically significant correlation between the MFAS and the mental health of the mother. Moreover, subsequent comparative analyses revealed a significant difference only in the case of socio-economic conditions, with women with a moderate socio-economic status showed higher levels of maternal-foetal attachment. Conclusions: The degree of maternal-foetal attachment is not significantly influenced by social characteristics such as age, education level, socio-economic context, or place of residence. The MFAS measured the attachment relationship. However, the study found no statistically significant correlation between the mother’s mental health and this attachment.
Psychosocial Variables Associated with Postpartum Depression in Breastfeeding Women: A Prospective Study
Authors: Catala Patricia , Gutiérrez Lorena , Ecija Carmen , Peñacoba Cecilia
Published: March 2024

Background: To analyze (Aim 1) if there is an association between maintaining breastfeeding for 4 months after delivery and postpartum depression (n = 160) and (Aim 2) what sociodemographic, obstetric and psychosocial factors are associated to the presence of postpartum depression among the women who continue to breastfeed for 4 months after delivery (n = 81). Methods: A total of 160 women who initiated exclusive breastfeeding within an hour of childbirth participated for Aim 1. For Aim 2, a total of 81 of these same participants, specifically those who continued breastfeeding 4 months after giving birth, constituted the final sample. For Aim 2, a prospective design was used, which included four stages. During the first trimester of pregnancy, pregnancy worries, extroversion and neuroticism, external locus of control and psychiatric symptoms were assessed. In the third trimester of pregnancy, psychiatric symptoms were assessed again. Immediately after childbirth, the initiation of exclusive breastfeeding was recorded, and four months after childbirth, both postpartum depression scores and the continuation of breastfeeding were assessed. Likewise, different sociodemographic and obstetric variables were assessed, including age, type of delivery, pain during and after delivery, among others. Results: In relation to Aim 1, no statistically significant associations were found between postpartum depression and the continuation of breastfeeding four months after childbirth. In relation to Aim 2, the presence of postpartum depression among the women who continued to breastfeed was associated to higher scores on neuroticism, pregnancy worries, external locus of control and anxiety and depression during both trimesters, as well as with lower extraversion scores. The results of binary logistic regression showed that, of the above variables, anxiety during the third trimester was the strongest predictor. Conclusions: It seems as though it would be necessary to assess psychosocial risks to be able to prevent postpartum depression and therefore improve mothers’ wellbeing during breastfeeding.
Investigation on the Different Needs of Practicing Doctors for Continuing Medical Education under the Three-Level Medical System in China
Authors: Wang Hanbi , Sun Aijun , Zhang Zhiyuan , Chen Jie , Dong Han , Zou Ying , Wang Wei , Zheng Qingmei , Feng Ying , Tan Zhangyun , Zeng Xiaoqin , Zhao Yinqing , Wang Yanfang
Published: March 2024

Background: To explore the needs of obstetricians and gynecologists (OB-GYNs) for training methods and contents, under China’s three-level diagnosis and treatment system. Methods: Epidemiological investigation was adopted, and network questionnaires were distributed in the largest academic training platform of obstetrics and gynecology in China, from April 2020 to May 2020. The investigation contents mainly included training methods and contents of continuing medical education (CME), as well as the mastery of diseases by doctors from hospitals at different levels of training. Results: The questionnaire received a total of 16,400 cumulative page views. 4458 questionnaires were collected in total, and 3954 questionnaires were included in the research. Doctors from hospitals at different levels chose the professional direction of gynecological endocrine diseases as the subject requiring the most strengthening of training, with ratios of 80.47%, 81.60% and 82.10%, respectively. Abnormal uterine bleeding (AUB) was the most desirable training content for doctors from primary, secondary, and other hospitals, while training of polycystic ovary syndrome (PCOS) was mostly needed by doctors from tertiary hospitals. According to the investigation, network education was the major training form favored by doctors, as well as a preferential way to acquire professional resources. The number of doctors selecting site meeting report only took up 4.70%. Based on the single-factor chi-square (χ2) analysis of the degree of mastery of 19 diseases, significant statistical differences were found among doctors from hospitals at each level, except for birth control (p < 0.001). After related factors were corrected, the multivariate regression analysis indicated that the degree of mastery of diseases was positively correlated to hospital levels. Conclusions: Doctors from hospitals at each level failed to effectively master gynecological endocrine diseases, and AUB, menopausal syndrome, and PCOS were confirmed as diseases for which the doctors had the greatest need of continuing education.
Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
Authors: Guillén-Ruiz Gabriel , Bernal-Morales Blandina , Limón-Vázquez Ana Karen , Olmos-Vázquez Oscar Jerónimo , Rodríguez-Landa Juan Francisco
Published: March 2024

Background: The flavonoid chrysin produces rapid and long-lasting anxiolytic- and antidepressant-like effects in rats. However, it is not known whether low and high doses of chrysin produce differential anti-immobility effects through the Gamma-Aminobutyric Acid sub-type A (GABAA) receptor. The goal of this work was therefore to compare low and high doses of chrysin for their effects on depression-like behavior in a longitudinal study. Moreover, chrysin was compared with the serotonergic fluoxetine and Gamma-Aminobutyric Acid (GABA)ergic allopregnanolone, and its involvement with the GABAA receptor after chronic treatment was also investigated. Methods: Male Wistar rats were assigned to five groups (n = 8 each): vehicle, 1 mg/kg chrysin, 5 mg/kg chrysin, 1 mg/kg fluoxetine, and 1 mg/kg allopregnanolone. In the first experiment, treatments were injected daily and the effects on locomotor activity and the forced swim test were evaluated at 0, 1, 14, and 28 days of treatment, and 48 h after the final treatment. In the second experiment, similar groups were treated for 28 days with injection of 1 mg/kg picrotoxin to investigate the role of the GABAA receptor. Depending on the experimental design, one- and two-way analysis of variance (ANOVA) tests were used for statistical analysis, with p < 0.05 set as the criteria for significance. Results: In both experiments, the treatments did not alter locomotor activity. However, low and high doses of chrysin, allopregnanolone, and fluoxetine gradually produced antidepressant-like effects in the forced swim test, and maintained this effect for 48 h post-treatment, except with low dose chrysin. Picrotoxin blocked the antidepressant-like effects produced by low dose chrysin, but did not affect those produced by high dose chrysin, allopregnanolone, or fluoxetine. Conclusions: The differential antidepressant-like effects caused by low and high doses of chrysin are time-dependent. Low dose chrysin produces a rapid antidepressant-like effect, whereas high dose chrysin produces a delayed but sustained the effect, even 48 h after withdrawal. The effect with high dose chrysin was similar to that observed with allopregnanolone and fluoxetine. The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.
Single Session Effects of Prolonged Continuous Theta Burst Stimulation Targeting Two Brain Regions on Pain Perception in Patients with Painful Diabetic Neuropathy: A Preliminary Study
Authors: Thakkar Bhushan , Peterson Carrie L. , Acevedo Edmund O.
Published: March 2024

Background: Painful diabetic neuropathy (pDN) is the most common cause of neuropathic pain (NP) in the United States. Prolonged continuous theta burst stimulation (pcTBS), a form of repetitive transcranial magnetic stimulation (rTMS), is quick (1–4 minutes) and tolerable for most individuals, compared to high frequency rTMS and can modulate pain thresholds in healthy participants. However, its effects on patients with chronic pain are still unclear. The primary purpose of this preliminary study is to investigate the effects of single session pcTBS targeted at the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) on a set of self-report measures of pain (SRMP) that assess the (a) sensory-discriminative; (b) affective-motivational; and (c) cognitive-evaluative aspects of pain experience. Methods: For this prospective, single-blind study, forty-two participants with pDN were randomized to receive either pcTBS targeting the M1 or the DLPFC brain regions. SRMP were completed at baseline, post pcTBS and 24h-post pcTBS. A two-way mixed model repeated measures analysis of variance (2 brain regions by 3 time points) was conducted to evaluate the effects of pcTBS stimulation at M1 and DLPFC for each subscale of each SRMP. Results: After a single session of pcTBS targeted at M1 or DLPFC in patients with pDN, statistically significant improvements from baseline to post pcTBS and baseline to 24 h-post pcTBS were observed for different SRMP subscales examining the (a) sensory-discriminative, (b) affective-motivational and (c) cognitive-evaluative components of the pain experience. At 24 h-post pcTBS, none of the participants reported any serious adverse events to the pcTBS treatment, thus demonstrating its feasibility. Conclusions: In pDN patients with NP, our study results demonstrated significant improvement in scores on self-report measures of pain (SRMP) after a single session of pcTBS targeting the M1 and DLPFC brain regions. Future studies should consider utilizing multiple sessions of pcTBS to evaluate its long-term effects on pain perception, safety and tolerability in patients with chronic pain. Clinical Trial Registration: This study was registered on the ClinicalTrials.gov website (NCT04988321).
Effects of Body Mass Index and Body Weight on Plasma Concentration of Ticagrelor and Platelet Aggregation Rate in Patients with Unstable Angina in a Chinese Han Population
Authors: Guo Houling , Li Qingqi , He Fei , Cheng Cheng , Wang Min , Xu Banglong , Wang Xiaochen , Sheng Jianlong
Published: March 2024

Background: The aim of this study was to investigate the impact of body mass index (BMI) and body weight on the concentrations of ticagrelor and the ticagrelor metabolite, AR-C124910XX, as well as the platelet aggregation rate (PAR) in a Chinese Han population with unstable angina (UA). Specifically, it focused on these parameters following the administration of dual antiplatelet therapy (DAPT) comprising aspirin and ticagrelor. Methods: A total of 105 patients with UA were included in the study. Measurement of the platelet aggregation rate induced by adenosine diphosphate (PAR-ADP) was performed before, as well as 3 and 30 days after DAPT treatment. The plasma concentrations of ticagrelor and AR-C124910XX were detected at 3 and 30 days after DAPT treatment. We conducted correlation analyses to assess the effects of BMI and body weight on the concentrations of ticagrelor and AR-C124910XX, on PAR-ADP, and on the inhibition of platelet aggregation induced by adenosine diphosphate (IPA-ADP) at both 3 and 30 days after DAPT treatment. Results: The BMI and body weight were positively correlated with baseline PAR-ADP (r = 0.205, p = 0.007; r = 0.122, p = 0.022). The PAR-ADP at 3 and 30 days after DAPT treatment were significantly lower than at baseline (61.56% ± 10.62%, 8.02% ± 7.52%, 12.90% ± 7.42%, p < 0.001). There was a negative correlation between body weight and the concentrations of ticagrelor and AR-C124910XX at 3 days following DAPT treatment (r = –0.276, p < 0.001; r = –0.337, p < 0.001). Additionally, BMI showed a similar negative correlation with the concentrations of ticagrelor and AR-C124910XX (r = –0.173, p = 0.009; r = –0.207, p = 0.002). At 30 days after treatment, both body weight and BMI were negatively correlated with ticagrelor (r = –0.256, p < 0.001; r = –0.162, p = 0.015) and its metabolite (r = –0.352, p < 0.001; r = –0.202, p = 0.002). Body weight was positively correlated with PAR-ADP (r = 0.171, p = 0.010) and negatively correlated with IPA-ADP (r = –0.163, p = 0.015) at 30 days after treatment. Similarly, BMI was positively correlated with PAR-ADP (r = 0.217, p = 0.001) and negatively correlated with IPA-ADP (r = –0.211, p = 0.001) at the same time point. Conclusions: BMI and body weight are key factors influencing the pharmacokinetics and pharmacodynamics of ticagrelor in Chinese Han patients with UA following DAPT treatment that includes ticagrelor. Both BMI and body weight were positively correlated with PAR-ADP at baseline and 30 days after DAPT treatment. Clinical Trial Registration: ChiCTR2100044938, https://www.chictr.org.cn/.
Multilayer Flow Modulator Stent for Aortic Pathology: A Meta-Analysis and Additional Data from a Single-Centre Retrospective Cohort
Authors: Özdemir-van Brunschot Denise M.D. , Zerellari Romina , Tevs Maria , Wassiljew Sergei , Holzhey David
Published: March 2024

Background: Thoracoabdominal aneurysms and aortic dissections are a challenge for vascular surgeons. Open surgery, fenestrated or branched endograft, and the chimney technique are not possible in some patients, because of comorbidities or anatomical restrictions. However, the multilayer flow modulator (MFM) can be implanted in some of these patients. In this systematic review, we will describe the experience with the multilayer stent. To augment the limited number of studies available, we will include a cohort of patients from our hospital. Methods: We retrieved data on all consecutive patients treated using the MFM between May 2013 and August 2020. This included patients with type B dissections and thoracoabdominal or thoracic aneurysms who were unfit for open surgery. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included all the studies that used the MFM in the aortic segment. Single-arm meta-analyses were performed using OpenMeta (Brown University, Providence, RI, USA). Results: A total of 37 patients were treated in our hospital during the study period. The technical success was 97.3% and the 30-day mortality was 5.4%. In 40.5% of the included patients, the instructions for use were not followed. Off-label implantation was associated with a higher aneurysm-related mortality. A total of 12 studies were included in the meta-analysis and the technical success was 97.8%. In 68.5%, the aneurysm sack or false lumen remained perfused, 97% of all the covered side branches remained patent. After a follow-up period of 1 year, five patients in the meta-analysis presented with a ruptured aneurysm. Conclusions: The overall quality of evidence is poor because long-term results are lacking, patients are frequently lost during follow-up and all the studies were non-comparative. Our retrospective study suggests a relatively low incidence of perioperative complications, although there was a high incidence of persistent perfusion in the aneurysm sac (102 of 149 patients). The risk of rupture at the 1-year follow-up was 2.1%.
The Heart Renaissance
Authors: Figueredo Vincent Michael
Published: March 2024

Ancient societies believed the heart was the most important organ in the body. Ancient religions held that only through the heart could one connect with God. During Europe’s Middle Ages there was little to no advances regarding the heart’s workings. As the Middle Ages gave way to the Renaissance, scientists and physicians began questioning long-standing theories on the heart. The first accurate descriptions of the heart and its function were written, and the first anatomically correct representations of the heart were drawn.
Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment
Authors: Huang Xuewei , Hu Lizhi , Long Zhuojun , Wang Xinyao , Wu Junru , Cai Jingjing
Published: March 2024

Hypertensive heart disease (HHD) presents a substantial global health burden, spanning a spectrum from subtle cardiac functional alterations to overt heart failure. In this comprehensive review, we delved into the intricate pathophysiological mechanisms governing the onset and progression of HHD. We emphasized the significant role of neurohormonal activation, inflammation, and metabolic remodeling in HHD pathogenesis, offering insights into promising therapeutic avenues. Additionally, this review provided an overview of contemporary imaging diagnostic tools for precise HHD severity assessment. We discussed in detail the current potential treatments for HHD, including pharmacologic, lifestyle, and intervention devices. This review aimed to underscore the global importance of HHD and foster a deeper understanding of its pathophysiology, ultimately contributing to improved public health outcomes.
Efficacy and Safety of PSCK9 Inhibitors on Patients with Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Authors: Zhao Jiajing , Tong Xinyu , Peng Jian , Lyu Chuxin , Lu Shu
Published: March 2024

Background: PCSK9 MaB (Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor) may reduce the occurrence of major adverse cardiovascular events (MACEs) in patients diagnosed with acute coronary syndrome (ACS). In this meta-analysis, we conducted a thorough compilation of evidence from established clinical studies to evaluate PCSK9 MaB’s capacity to control blood lipid levels and prevent MACEs in ACS patients. Methods: We conducted searches on Pubmed, Embase, the Cochrane Library, and Web of Science to identify relevant articles. Data from ACS patients were extracted using a standardized format for aggregating data. We calculated the risk ratio (RR) for MACE and assessed changes in blood lipid parameters. All statistical analyses were performed using RevMan. Results: 11 articles representing 5 trials were included in our systematic review and meta-analysis. When compared to a placebo, PCSK9 MaB significantly reduced the risk of MACEs (I2 = 0%, p = 0.63, RR [95% CI] = 0.88 [0.81, 0.97], p < 0.01) and the recurrence rate of ACS (I2 = 45%, p = 0.18, RR [95% CI] = 0.89 [0.83, 0.95], p < 0.01). Additionally, PCSK9 MaB notably reduced low-density lipoprotein cholesterol (LDL-C) levels (SMD [95% CI] = –2.12 [–2.32, –1.92], p < 0.01) and Apolipoprotein B (ApoB) levels (SMD [95% CI] = –1.83 [–2.48, –1.18], p < 0.01). Importantly, there were no significant differences in adverse reactions between the PCSK9 MaB group and the control group. Conclusions: PCSK9 MaB, whether used as a standalone treatment or in combination with other therapies, can effectively inhibit PCSK9. It substantially lowers key blood lipid parameters, including low-density lipoprotein (LDL), ApoB, and triglycerides, all without giving rise to notable safety concerns.
Association of Postoperative Atrial Fibrillation Duration after Coronary Artery Bypass Grafting with Poor Postoperative Outcomes
Authors: Qin Haokai , Xie Enzehua , Peng Zhan , Yang Xiubin , Hua Kun
Published: March 2024

Background: Postoperative atrial fibrillation (POAF) has long been associated with poor perioperative outcomes after coronary artery bypass grafting (CABG). In this study, we aimed to investigate the effect of prolonged POAF durations on perioperative outcomes of CABG. Methods: This retrospective cohort study examined CABG patients enrolled at Beijing Anzhen Hospital from January 2018 to September 2021. We compared patients with POAF durations ≥48 hours to patients with POAF durations <48 hours. Primary outcomes were in-hospital mortality, stroke, acute respiratory failure (ARF), acute kidney injury (AKI), and significant gastrointestinal bleeding (GIB); secondary outcomes were postoperative length of stay (LOS) and intensive care unit (ICU) duration. Associations between primary outcomes and POAF duration were determined using logistic regression and restricted cubic spline analyses. Differences in baseline characteristics were controlled using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). Results: Out of 11,848 CABG patients, 3604 (30.4%) had POAF, while 1131 (31.4%) had it for a duration of ≥48 hours. ARF (adjusted odds ratio [OR]: 2.96, 95% confidence interval [CI]: 1.47–6.09), AKI (adjusted OR: 2.37, 95% CI: 1.42–3.99), and significant GIB (adjusted OR: 2.60, 95% CI: 1.38–5.03) were associated with POAF durations ≥48 hours; however, neither in-hospital mortality (adjusted OR: 1.60, 95% CI: 0.97–2.65) nor stroke (adjusted OR: 1.28, 95% CI: 0.71–2.34) was. These results remained even following PSM and IPTW analyses. Conclusions: POAF durations longer than 48 hours were independently associated with poorer perioperative recovery from CABG, with respect to the occurrence of ARF, AKI, and GIB, as well as a longer postoperative LOS and ICU duration. However, it was not associated with greater in-hospital mortality or stroke occurrence. All these findings suggest that postoperative monitoring of POAF and positive intervention after detection may be more helpful in optimizing post-CABG patient outcomes.
Pengaruh Circulo Massage Terhadap Penurunan Perasaan Kelelahan Kerja Guru Wanita Taman Kanak-Kanak Negeri
Authors: Danarstuti Utami  , Priska Dyana Kristi  , Hadiono  , Andri Arif Kustiawan
Published: March 2024

Stressor psikososial terdiri dari bagian pekerjaan, bagian keluarga, dan bagian masyarakat. Pengajar guru TK sebagai pendidik awal, harus dapat memberikan ilmu dasar, dan menjadi pribadi yang tangguh pada anak didiknya. Hal tersebut menyebabkan tubuh mengalami penurunan perasaan pada kelelahan kerja. Penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh dari circulo massage terhadap penurunan perasaan kelelahan pada kerja guru wanita TK. Penelitian ini merupakan penelitian pra-eksperimen dengan one group pretest-posttest designs dengan perlakuan circulo massage terhadap subjek/respondan, sedangkan teknik pengumpulan datanya menggunakan kuesioner dan populasinya adalah para guru wanita TK. Jumlah sampel pada penelitian ini sebanyak 12 orang. Teknik analisis data yang digunakan adalah uji-t dengan bantuan program berupa SPSS (Statistical Program for Social Science). Hasil menunjukkan skor pada perasaan kelelahan kerja rata-rata didapat sebelum = 38,67 dan sesudah = 24,42 terdapat selisih = 14,25 dengan t hitung = 6,362 pada derajat kebebasan atau degree of freedom (DF) = 11 dan diperoleh t tabel sebesar 2,201. Data menunjukkan besarnya nilai t hitung lebih besar dari t table dari hasil diatas, artinya terdapat penurunan yang signifikan dari perbandingan t hitung dengan t tabel. Dengan demikian dapat diambil kesimpulan bahwa circulo massage terbukti mempunyai pengaruh yang signifikan terhadap penurunan perasaan kelelahan pada kerja guru wanita TK.

 

Kata kunci: : circulo massage, kelelahan, guru TK
ТРАДИЦІЙНІ ТА СУЧАСНІ ФОРМИ МИСТЕЦТВА В ЗОВНІШНІЙ КУЛЬТУРНІЙ ПОЛІТИЦІ КИТАЮ
Authors: Руських Софія Олегівна
Published: March 2024

Метою статті є розкриття деталей еволюції китайського культурного ландшафту та його впливу на світовій арені в дипломатичному й міжкультурному контекстах, беручи до уваги культурні надбання як Китайської Народної Республіки, так і Республіки Китай. Дослідження узагальнює огляд актуальних тематичних публікацій, визначає невирішені питання, пропонує перспективи подальших досліджень у цій сфері. Як інструменти зовнішньої культурної політики аналізуються традиційні китайські перформативні мистецтва й сучасні форми культурного самовираження – маньхуа (комікси), дунхуа (анімаційні серіали), сі-поп (китайська популярна музика) та драми (фільми й серіали). Міждисциплінарний підхід дослідження слугує вивченню динамічного злиття традиційних і сучасних елементів у художньому вираженні; технологічних інновацій у цифровому мистецтві; соціальної ангажованості мистецтва як форми коментування, культурного активізму. Наукова новизна роботи полягає в цілісному підході, що поєднує традиційні й сучасні культурні форми, робить внесок у дискурс про культурну дипломатію та глобальні культурні взаємодії, зокрема, в українському академічному полі. Результати підкреслюють стратегічне використання різноманітних форм мистецтва в культурній дипломатії Китаю. Отримані результати роблять внесок як у наукову, так і в практичну сферу, забезпечуючи розуміння культурного впливу Китаю та закладаючи основу для майбутніх досліджень.
Diez objetivos que debemos abordar para entender y combatir la desinformación
Authors:   Universidade de Vigo, Míguez-González María-Isabel , Dafonte-Gómez Alberto ,   Universidade de Vigo
Published: March 2024

Disinformation is a growing phenomenon that affects contemporary societies, creates polarization, and poses a serious risk to democratic institutions. A strong media, information, and digital literacy among citizens, developed from an early age, is essential to address this problem. In this text, we present the ten objectives outlined in Stop Disinformation. A didactic guide to learn to verify, to understand disinformation and learn to combat it.
Geographic Comparison of Dietary Intake and Quality in Manitoba Adolescents
Authors: Slater Joyce , Katz Alan , Pilli Bhanu , Hinds Aynslie , Urquia Marcelo L , Sanguins Julianne , Green Chris , Cidro Jaime , Chateau Dan , Nickel Nathan
Published: March 2024

Purpose: The Food and Nutrition for Manitoba Youth (FANS) study examined dietary intakes, food behaviours, food security status, health indicators, and body mass index of a cohort of grade 9 students. This paper describes regional differences and similarities in dietary intake (food and nutrients) and quality of youth participants in the FANS study.

Methods: Grade 9 students completed a web-based survey on dietary intakes (24-hour recall), food behaviours, self-reported health indicators, and sociodemographic variables. Nutrient intakes were compared with national guidelines and diet quality was assessed using a modified Healthy Eating Index.

Results: A total of 1587 students participated from northern, rural, and urban regions in Manitoba. Northern and rural students had higher intakes of sugar, sodium, and saturated fat compared with urban. Northern students consumed fewer grain products compared to urban, and more servings of “other” foods compared with rural and urban. While most participants were classified into the “needs improvement” or “poor” Healthy Eating Index categories, significantly more northern participants were in the “poor” category.

Conclusions: Most adolescents in the study are at nutritional risk; however, there are additional vulnerabilities for those in rural and northern communities. Dietitians can use results to advocate for and plan interventions to improve adolescent nutrition.
Zinc(Ⅱ)-induced Neuroimmunological Renal Chronic Kidney Disease Prevention and Suppressive Progression
Authors: Ishida Tsuneo
Published: March 2024

Zinc(Ⅱ) supplementation with 30 mg/day should become likely therapeutic chronic kidney disease (CKD) prevention implications with immense importance of CKD-associated immunological and neurological complications. Zinc induced neuroimmunological suppressive CKD progression with Stage 2 ～ 3A, 3B, zinc supplementation (30 mg/day) may be beneficial for nutritional status in CKD children and adolescents, and zinc could reduce urinary protein excretion composed of albumin and/or minimize proteinuria excretion in proteinuric CKD. In CKD 4-5 stage, risk of cardiovascular disease (CVD) become higher that zinc supplementation of 25 mg/day in zinc homeostasis has a beneficial effect for CVD in vascular dysfunction. Thus, zinc intake of 30 mg/day and serum zinc level of 60～76 μg/dL could slow down CKD Stage 4 progression. Zinc induced CKD Stage 5 (eGFR < 15) is involved that zinc is actively bound to several proteins that the decrease of circulating zinc levels in CKD is partly caused by renal losses of zinc, becoming zinc-deficiency with advanced stage CKD and ESRD in CKD. Serum zinc and serum albumin levels are 37.4 ± 5.4 and 2.6 ± 0.6 µg/dL, respectively, for as eGFR 6.6 (5.2–8.3). Zn intake of 45-75 mg/day and serum zinc level of ≤78.3 µg/dL are beneficial for HD and maintenance hemodialysis (MHD) patients, in which Zinc 15 mg/day and Selenium 50–70 μg/day that are recommended may be thought to prevent ESRD stage. Zinc induced NAD(P)H oxidase (Nox) activation occurring ROS generation in CKD cell involves assembly that ROS include the superoxide anion (O2•–), hydrogen peroxide (H2O2), and hydroxyl radicals (OH•), and in the kidney. Zinc(Ⅱ) ions-binding protein molecular mechanism is involved that Zn2+ ions-several protein complexes coordinated binding model of ligands of such as albumin, a-macroglobulin and transferrin in several proteins had been found on the binding specificity by Zn2+ ions-centered tetrahedral geometric coordination, in which causing zinc-activated serine, histidine and aspartate hydrogen residues enhance renal function activity and resulting inhibition of CKD progression proceeds.
Modeling Perception Entrepreneurship in the Covid-19 Era
Authors: García Lirios Cruz
Published: March 2024

Purpose. The objective of this study is to study the literature related to social entrepreneurship published from 2020 to 2023 in order to model its theoretical dimensions in factors. Theoretical framework. Based on the theory of social entrepreneurship, which maintains that in the face of economic crises, communities disseminate information for economic cooperation, its opportunity dimensions are modeled: economic, political, social, financial, and environmental. Method. An exploratory, cross-sectional, psychometric and correlational study was carried out with a sample of 100 microentrepreneurs from a town in central Mexico selected for their participation in the local entrepreneurship and development system called magical towns. Practical and social implications. The established factorial model will make it possible to delimit local microfinancing policies for microenterprises. Originality. The value of the study lies in establishing the validity and reliability of an instrument that measures social entrepreneurship in the face of the pandemic.