bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Induced Mindfulness at Night on Repetitive Negative Thinking: Ecological Momentary Assessment Study
Authors: Sommerhoff Amanda , Ehring Thomas , Takano Keisuke
Published: May 2023

Background

Repetitive negative thinking (RNT) is a cognitive risk factor for various disorders. Although brief mindfulness-based interventions (MBIs; lasting 20-30 minutes or shorter) are effective tools to reduce RNT, the effect of a minimal (5-minute) MBI remains largely unknown.

Objective

We investigated the acute changes in RNT induced by a 10-day minimal MBI (body scan before sleeping) using an ecological momentary assessment (EMA) administered during the MBI training phase. In addition, we examined longer-term effects on the postintervention and 2-month follow-up assessments for questionnaire-based RNT and psychological distress.

Methods

A total of 68 participants (community sample, aged 18-55 years; n=58, 85% women) were randomly allocated to either the intervention group (n=35, 51%) or the no-training control group (n=33, 49%). Both groups completed a 10-day EMA phase of RNT, during which only the intervention group performed a daily 5-minute body scan before sleeping.

Results

The intervention group showed a significantly larger reduction in questionnaire-based RNT than the control group at the follow-up assessment (for growth-curve modeling analysis [GMA], dGMA=−0.91; P<.001), but this effect was not observed during the EMA phase or at the postintervention assessment. Furthermore, the intervention group showed significantly larger decreases in stress both at the postintervention (dGMA=−0.78; P<.001) and follow-up (dGMA=−0.60; P<.001) assessments than the control group. We found no intervention effects on depressive and anxiety symptoms.

Conclusions

A 5-minute body scan before sleeping reduces RNT and stress when continued for at least 10 days; however, the results suggest that this effect only appears with some time lag because no acute changes during and immediately after the intervention emerged for RNT.
Efficacy and Safety of F17464 in the Treatment of Acute Exacerbation of Schizophrenia: A Phase II Clinical Trial with AI-Based PANSS Analysis (Preprint)
Authors: STERN NETANEL
Published: May 2023

UNSTRUCTURED

F17464, a highly potent preferential D3 antagonist, is a novel compound under development for the treatment of schizophrenia. This article presents the findings from a phase II, double-blind, randomized, placebo-controlled study conducted in five European countries. The study aimed to evaluate the efficacy and safety of F17464 in patients with acute exacerbation of schizophrenia using the Positive and Negative Syndrome Scale (PANSS) as the primary outcome measure. Additionally, this study incorporated artificial intelligence (AI) for the analysis of PANSS scores in the treatment groups, providing objective and standardized assessments.
URBAN MOBILITY DURING THE PANDEMIC IN YOGYAKARTA CITY
Authors: Damanik Imelda Irmawati , Raniasta Yohanes Satyayoga
Published: May 2023

The urban situation has changed during COVID-19 pandemic since 2020. The swift of mobility behavior happened in all over the city in the world. The WHO’s suggestion to maintain NPIs; the physical distancing is a push factor for people to reduce traveling and mobility. The slogan ‘stay at home’ became part of the new normal until nowadays, because publication of it was spread on all media to reach out the society.  Yogyakarta City responds to the pandemic issue with the same strategy, minimizing mobility and travel. However, there is uniqueness in the practice on minimizing mobility and travel in 2020 and 2021. In 2020, the control of mobility and travel is based on community and in 2021 the control of mobility and travel is based on government policy. The security level of travel in 2020 is housing and urban kampung, and in 2021 is on the city level. The research is focused on the perception of respondent on minimizing travel and mobility between these two years. The data was analyzed using the Principle Component Analysis method. The quantitative result will be compared with observation, so it shows the important value to respond during uncertainty on travel and mobility issue. The study will give how local wisdom and public policy collaborate to produce urban resilience in Yogyakarta City.
Influence of SGLT2i and RAASi and Their Combination on Risk of Hyperkalemia in DKD
Authors: Luo Xiaoling , Xu Jing , Zhou Shoulian , Xue Cheng , Chen Zewei , Mao Zhiguo
Published: May 2023

Background

This network meta-analysis investigated the effect of various combined regimens of sodium-glucose cotransporter-2 inhibitors (SGLT2is) and renin-angiotensin-aldosterone system inhibitors (RAASis) on the occurrence of hyperkalemia in diabetic kidney disease.

Methods

The risk of hyperkalemia was compared using the random-effects model of network meta-analysis, with results expressed as odds ratios (ORs) with 95% confidence intervals (CIs). The comparative effects of all medications and their combinations with placebo were ranked using the surface under the cumulative ranking probabilities.

Results

In total, 27 eligible studies involving 43,589 participants with diabetic kidney disease were included. Major findings showed that the use of mineralocorticoid receptor antagonists (MRAs) on top of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) prominently increased hyperkalemia incidence when compared with placebo (OR, 6.08; 95% CI, 2.30 to 16.08), ACEI (OR, 3.07; 95% CI, 1.14 to 8.31), ARB (OR, 2.57; 95% CI, 1.10 to 6.02), SGLT2i (OR, 9.22; 95% CI, 2.99 to 28.46), renin inhibitors+ACEI/ARB (OR, 2.23; 95% CI, 1.14 to 4.36), or SGLT2i+ACEI/ARB (OR, 4.10; 95% CI, 2.32 to 7.26). Subgroup analysis among different generations of MRA found that spironolactone had the strongest effect in combination with ACEI/ARB, even higher than the combined use of ACEI and ARB (OR, 2.89; 95% CI, 1.26 to 6.63). In addition, SGLT2i had a significantly lower incidence of hyperkalemia compared with ACEI (OR, 0.33; 95% CI, 0.12 to 0.91), ARB (OR, 0.28; 95% CI, 0.13 to 0.61), dual RAASi (ACEI combined with ARB; OR, 0.17; 95% CI, 0.06 to 0.47), or MRA or renin inhibitors combined with ACEI/ARB (OR, 0.11; 95% CI, 0.04 to 0.33; OR, 0.24; 95% CI, 0.08 to 0.76, respectively). Moreover, adding SGLT2i to the combination of MRA and ACEI/ARB, as well as the combinations of different RAASis, markedly reduced the occurrence of hyperkalemia.

Conclusions

Among the therapeutic drugs with the potential risk of increasing serum potassium in patients with diabetic kidney disease, MRA added an extra risk of hyperkalemia while SGLT2i had the opposite effect and could even reverse the elevation of serum potassium caused by the combined regimen, including MRAs.
Editorial
Authors: Zamora Centli
Published: May 2023

Desde que en 1882 se descubriera el bacilo de la tuberculosis, se desencadena una carrera científica para vencer a una enfermedad que se convirtió durante la primera mitad del siglo xx en la principal causa de mortalidad en España.

Una de las medidas para luchar contra ella fue la puesta en marcha por parte del Patronato Nacional Antituberculoso (PNA) de un ambicioso plan de construcciones que consiguiera crear una completa red de sanatorios donde alojar y atender en las mejores condiciones posibles a los enfermos. Estudios como los de los doctores Bassols o Valenzuela comenzaron a crear las bases documentales para establecer y dar a conocer tanto a médicos como arquitectos los lugares y condiciones más idóneas para construir estos sanatorios.

¿Dónde se construyeron finalmente estos gigantes de la sanidad española? ¿En qué situación se encuentra actualmente este legado arquitectónico y cultural de nuestra historia? Muchas de las piezas hoy heredadas y diseminadas por todo lo ancho del territorio español se encuentran en un alarmante estado de abandono.

Este artículo pretende otorgar justicia a todo el conjunto de la operación de diseño y construcción del PNA sacando a la luz una obra realmente espectacular que recorre toda la geografía española.
A propósito de Paraguay
Authors: Uribe Ortiz José Luis
Published: May 2023

El presente artículo plantea una serie de apuntes que conforman una aproximación a la manifestación arquitectónica de Paraguay en las últimas décadas, revisada bajo el punto de vista del proceso artesanal como método de proyecto y obra. Su contenido se centra específicamente en la férrea asociación que los arquitectos establecen con los artesanos locales, configurando un proceso creativo basado en el constante intercambio de experiencias en torno a la dimensión constructiva. Esta manera de operar ha determinado la expresión formal, material y espacial de la reciente arquitectura en Paraguay, una práctica situada en los bordes de lo usual, como parte de una manifestación que da cuenta de un estado de conciliación entre el habitante y el entorno cultural en el cual se desenvuelve. Esta condición ha permitido situar a un pequeño grupo de arquitectos de este país como referentes de la arquitectura contemporánea.
Fue un libro
Authors: Hogrebe Rodríguez Jimena
Published: May 2023

Este ensayo es una reflexión sobre la actividad de escribir sobre arquitectura partiendo de mi propia experiencia. Cuenta mi recorrido por la escritura arquitectónica, el papel que ha tenido en mi práctica y la manera en la que he relacionado el texto con esta disciplina. Es un paseo cronológico a partir de momentos clave de mi historia en el que hago referencia a textos y personas que han marcado mi camino por esta labor.
Siete poemas de Antonia Pozzi
Authors: Guerrero Guzmán Idelfonso Román
Published: May 2023

A través de una selección de siete poemas de la autora milanesa Antonia Pozzi, se asiste al recorrido por algunos de los temas que surcaron los campos de su vida: sus amores, sus pérdidas, los anhelos y la muerte, mismos que, con virtuosismo y cercanía emocional, develan las profundas huellas que el mundo y ciertas personas dejaron en la vida de la poeta.
"Los persas de esta historia": lo poético-político en José Saramago
Authors: Baltrusch Burghard
Published: May 2023

La principal razón de la “saramagia”, término acuñado en México en 1998, se debe a la visita que Saramago hizo a Chiapas después de la masacre de Acteal, y a la recepción calurosa que recibió por parte de tantos agentes culturales y sociales en sus múltiples visitas al país. En el ensayo “Chiapas, nombre de dolor y esperanza” (1998), en defensa de los pueblos indígenas, Saramago recurrió a la metáfora de los “persas”, en alusión las Lettres Persanes (1721) de Montesquieu, para incidir sobre la importancia de aprender a entender al Otro desde su lugar y perspectiva. Este artículo argumenta que existe una condición poético-política en la vida y obra de José Saramago. A partir de breves análisis de aspectos seleccionados del libro de poemas El año de 1993 (1975) y de las novelas Memorial del convento (1982), El año de la muerte de Ricardo Reis (1984) y El viaje del elefante (2008), se concluye que el episodio de Chiapas ilustra una superposición de vida y obra desde una conciencia crítica y éticamente responsable. Lo poético-político en Saramago podría ser interpretado como un empeño simultáneamente liberador y libertario, para enfrentar, entre otros aspectos, el neocolonialismo económico-político y el capitalismo patriarcal. Se constata, con ciertas reservas, una proximidad con elementos artivistas y performativos, al igual que con el pensamiento de la decolonialidad. Esto también permitiría comparar a la obra y el activismo saramaguiano, incluyendo también a su pensamiento transiberista, con formas artísticas que procuran performar políticamente un conocimiento crítico.
Village Farmer Community Empowerment Efforts (Study of Farmer Social Capital in the Pesantren Petani Nusantara Program, Pangandaran Regency)
Authors: Widaty Cucu
Published: May 2023

This study describes the community empowerment program for farmers through Pondok Pesantren Petani Nusantara program. This is motivated by the lives of people who are experiencing various problems, such as shifting farmers' livelihoods, the number of poor farmers, and also the low education of farmers who are not yet empowered and not independent. The research method used is a descriptive method with a qualitative approach. The subjects in this study were program managers, farmers and program participants, as well as the government. The results of this study can be seen that the beginning of the establishment of the Pondok Pesantren Petani Nusantara program in 2004 was the idea and aspiration of the farmers in the village of Pangandaran who wanted to advance their potential to be more advanced and prosperous. This is proven by the three excellent programs that continue to develop until now, namely the Prosperous Farmers Group (KTS), Women's Farmer Group (KWT), and Youth Farmer Training (PATRA). In implementing programs such as the farmers' program, they are less concerned and do not support the program, farmers who have other activities cannot be carried out in the meeting program, and there are also disputes that cause a lack of farmer participation. The benefits of farmers are an increase in the economy, an increase in the number of farmers, a stronger sense of solidarity in farming, an increase in knowledge and skills, and an increase in livelihoods or urbanization. The government actively supports the program by providing various facilities and infrastructure, as well as conducting monitoring and evaluation.
Demonstration of the Antioxidant Potential of Three Newly Isolated Carotenoid-Producing Microscopic Algae from KwaZulu-Natal (South Africa)
Authors: Adedoyin Ayodeji E. , Schmidt Stefan
Published: May 2023

Natural carotenoids from green microalgae exhibit beneficial effects in treating health-related diseases, primarily due to their antioxidant capacity. Therefore, carotenoid-producing microalgae were isolated and characterized from aqueous samples in KwaZulu-Natal (South Africa) under photoautotrophic conditions. Three isolates were characterized comprehensively using light and electron microscopy. In addition, the growth of the three selected microalgae was evaluated under photoautotrophic and photoheterotrophic conditions. Based on the cytological characteristics, the three strains matched the genera Haematococcus, Parachlorella, and Scenedesmus, the latter two additionally confirmed via analysis of the 18S rRNA gene sequence at the genus level. Light and electron microscopy and UV-Vis spectroscopy confirmed pigment production by all three microalgal strains. Both isolate Parachlorella sp. AA1 and Scenedesmus sp. AA2 showed the highest growth rate when cultured with acetate (25 mM) photoheterotrophically, while the isolate Haematococcus sp. AA3 grew best with glucose (50 mM). In addition, all three isolates utilized salicylate as a carbon source under photoheterotrophic conditions, evidently resulting in increased carotenoid production in strains AA1 and AA3. The 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) antioxidant assay confirmed that methanol extracts of all three isolates contained carotenoids that can scavenge radicals, and thin layer chromatography (TLC) analysis showed that β-carotene and astaxanthin were formed by strain AA3 as main carotenoids.
Antibacterial and Cytotoxic Activity of Mentha arvensis L. Leaves Methanolic Extract In vitro
Authors: Saleh Bushra Hindi , Al-ugaili Dhafar N. , Oraibi Asma G. , Ibrahim Rasha Abdalelah
Published: May 2023

Treatment with herbal drugs is considered one of the oldest and safest methods for treating various diseases. Mentha arvensis is a medicinal plant used worldwide in the pharmaceutical industry for its antibacterial, anticancer, antiallergic, and anti-inflammatory properties. In the present study, the antibacterial activity of the methanolic extract of M. arvensis leaves was tested at different concentrations (50, 100, 150, and 200 µg/ml) against bacteria isolated from human burn wound infections, including Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. The results demonstrated that at concentrations of 100, 150, and 200 µg/ml, the methanolic extract exhibited strong antibacterial activity against S. aureus and P. aeruginosa, while K. pneumoniae isolates were resistant to the extract at all tested concentrations. Further, the cytotoxic activity of the methanolic extract was assessed at various concentrations (100, 140, 160, 180, 220, and 250 µg/ml) against two cell lines: the RD tumor cell line and Vero normal cell line. The higher concentrations of the extract (220 and 250 µg/ml) showed potent cytotoxic effects on the RD cell line after 72 hours in a dose- and time-dependent manner. In contrast, the extract exhibited lower cytotoxic effects on Vero cells at the same concentrations after 72 h.
Detection of Attention Deficit/Hyperactivity Disorder (ADHD)
Authors: R Pavithra , S Anuu Karthiga I , A Jeyashree , Sampath Sreemathi , V Sruthi
Published: May 2023

Abstract: In recent years, Machine Learning has had a huge impact on a range of technological disciplines. As technology expands, machine learning provides an exciting opportunity in health care to help medical professionals care for patients and manage clinical data. It improves the accuracy of diagnoses, personalize health care, and find novel solutions to decades-old problems. Hospitals and health care companies have begun to recognize the ability of machine learning to improve decisionmaking and reduce risk in the medical field, which has led to several new and exciting career opportunities. Attention Deficit/Hyperactivity Disorder (ADHD) is a chronic condition generally characterized by hyperactivity, impulsiveness, and difficulty in paying attention. The early diagnosis of ADHD is highly desirable, and there is a need for developing assistive tools to support the diagnosis process in this regard. At present, there are two main methods available - using fMRI data and tracking eye movements. The proposed approach offers a method to assist with the ADHD diagnosis with an emphasis on young children who are still in the early stages of development. It tries to discover the eye-tracking patterns of ADHD using machine learning. The fundamental concept is to convert eye-tracking scan-paths into a visual representation, thus the diagnosis may be viewed as an image classification task.
A Quantitative Study of Enterprise Resource Planning (ERP) System and it’s Applications
Authors: Chavan Aayush , Mandhalkar Vaishnavi , Chandrakant Dr. Uday
Published: May 2023

Abstract: Enterprise Resource coming up with (ERP) system consists of various sets of business functions in company or organization. Only if these results offer an integrated solution to the requirement of a company, these systems square measure in high demand by all organizations. The replete potential of those systems will solely be complete as long as they are enforced with success. However, the implementation method is expensive and time ingesting and therefore needs careful projecting and organization. If with success enforced, ERP systems offer several advantages to those organizations that adopt them. By examining the prevailing literature on this subject, this report focuses on how ERP systems may be with success enforced in organization and also the vital success factors. The knowledge provided during this research could also be want to guide organizations within the implementation of ERP systems.
Sudoku Solving Algorithm and Grid Based Models for Digit Recognition
Authors: Nikita Ms.
Published: May 2023

Abstract: In recent information technology advances, computer vision has been exalted. Due to its broad range of uses and features, it has gained attention for resolving difficult problems in the real world that are beyond the capacity of human intellect. This marvel of artificial intelligence becomes practical and convenient when it is applied to everyday life. Sudoku has been a common source of entertainment in many articles in newspapers, magazines, and applications. The conclusion of this research is to use computer vision techniques to solve the Sudoku puzzle. We used some well-known tools, including Open CV, OCR, and Tensorflow. The strategy we utilised to employ these tools to solve the Sudoku puzzle is described in the paper. The paper's technique includes a number of stages, including.
Xperia Search Engine
Authors: Jha Radhika
Published: May 2023

Abstract: This research paper delves into the innerworkings of search engines and introduces Xperia, a personalized search engine aimed at enhancing information retrieval. The paper explores the fundamentaltechnologies employed by search engines, tracing their evolution and growth over time. It presents the development and implementation of Xperia, highlighting its unique feature set that goes beyond traditional search engines by providing users with not only relevant resourcelinks but also extracted information from various web sources. The paper begins with an introduction, providing the background and motivation for the research, as well as outlining the research objectives and scope. It then delves into the fundamentals of search engines, discussing their components, crawling and indexing processes, ranking algorithms, and user interfaces. The evolution of search engine technologies is examined, from the early stages to the current advancements in semantic search, natural language processing, and the incorporation of machine learning and artificial intelligence.
Comparative Study and Static Analysis of Piston Using Solid Edge and Ansys
Authors: KS Mohan Kumar
Published: May 2023

Abstract: A piston is a component of reciprocating engines. The purpose of piston is to transfer force from expanding gas in the cylinder to the crankshaft via a piston rod and a connecting rod. It is one of the most complex components of an automobile. In This project we are describes the Thermal analysis by using finite element method (FEM). The specifications used for designing the piston belong to four stroke single cylinder engine of piston. Modeling of piston are done using SOLID EDGE v20. static structural, Thermal and fatigue analysis is performed by using ANSYS WORKBENCH 2022 R1. The parameters used for the simulation are operating gas pressure, material properties of piston. The results predict the maximum stress and strain on pistons using FEA. The best material is selectedbased on static structural, thermal and fatigue analysis. The analysis results are used to optimize piston geometry of best two Materials.
Trends in Cyber Crime in India
Authors: Dahiya Kashish
Published: May 2023

Abstract: This research paper explores the trends in Cyber Crime in India, considering the country's rapidly growing digital landscape and the associated risks. The introduction provides an overview of the digital transformation in India and its dual impact, highlighting the alarming increase in Cyber Crime. One prominent trend discussed is the rise of phishing attacks, where cyber criminals employ deceptive tactics to trick individuals into revealing sensitive information. Another concerning trend is the proliferation of Ransomware attacks that target various sectors, causing significant financial losses and operational disruptions. Additionally, cyber fraud targeting financial transactions and digital payment systems has become prevalent. The paper also highlights the risks associated with social media platforms and online marketplaces, including identity theft and the sale of illegal goods and services. To address these escalating cyber threats, the paper emphasises the importance of prioritising cybersecurity measures, raising awareness about safe online practices, and establishing robust legal frameworks. The findings underscore the urgent need for individuals, organisations, and the government in India to work together to combat Cyber Crime effectively and secure the nation's digital future
Enhancing Community based Development on Tourism - A Case Study of Nayagarh, Odisha
Authors: Nayak Tizalin
Published: May 2023

Abstract: In the Nayagarh district of Odisha, the Khandapada, Nayagarh, and Gania Block are the subjects of this study, which looks at both the local’s and tourist's perspectives on community-based development. The view and intentions of the local community towards the socioeconomic aspects of ecotourism, specifically sustainable community development and local community involvement in ecotourism planning and management, were assessed. The study region tourist sites are surrounded by locals who live there, and the analysis is based on data gathering and survey through questionnaire interviews with them. The results of the Survey indicate that residents support growth and enhancement of the neighborhood, although there are some local problems and requests that must be addressed. There is a lot of opportunity for community-based development on brass and metal work around the hill where the temple of Lord Nilamadhava temple. The majority of Lord Jagannath's Puri festivities are observed here, with the Bhauma Ekadasi being the most notable. In addition, socioeconomic issues must be addressed, and a framework for community empowerment must be proposed in order to raise awareness among the populace and ensure that they receive equitable benefits from the study area's recreational activities. These demands are made by the local communities.
Prediction and Sentiment Analysis of Stock using Machine Learning
Authors: K Bharath Gowda B , K Ashitha B , Suresh Shree Sakshi , Vishal S , Shilpa Mrs. T
Published: May 2023

Abstract: The stock market is highly volatile and subject to rapid fluctuations and changes, with seemingly insignificant news or rumors potentially impacting the value of a stock. This project aims to assist retail investors in navigating the complex and volatile modern stock market by developing machine learning models for predicting stock market trends and identifying promising stocks. The solution involves components to facilitate data collection through sitemap spider, data processing through coreference resolution technique, model training using random forest, and sentiment analysis for the stock sentiment. The results of sentiment analysis are merged with technical indicators data to create the dataset for training. The proposed system has shown results with 72% accuracy in assisting investment decision making. The project's applications extend to news analysis, investment decision-making, risk management and trading strategies.
Examining How the Addition of AL2O3 and CEO2 Nanoparticles to Used Cooking Oil May Affect Engine Operation, Combustion, and Emissions
Authors: Yadav Devesh , Bhan Suraj , Haseeb Mohd Daniyal , Siddique Mohd Aamil , Singh Pranjal
Published: May 2023

Abstract: The objective of this study is to compare the combustion, emissions, and engine performance of two different modified fuels. The oxygenated nanoparticles (CeO2 and Al2O3) were homogeneously mixed into B20 with an ultra sonicator at a specific ratio of 50,100 ppm to explore the potential of nanoparticles as a flexible booster in physiochemical properties of biodiesel. The generated nanoparticle fuel samples are then put to the CRDI VCR engine at various loads (3,6,9,12 kg): B20+50 Al2O3, B20+100 Al2O3, B20+50 CeO2, B20+100 CeO2. The different nano fuel's engine capabilities, combustion, and emissions are then contrasted with biodiesel, diesel, and one another. Performance-wise, BTE was 11.39% higher and SFC was 13.74% lower than B20 for B20+ 50 Al2O3 at high load. The cylinder pressure and heat release rate for B20+50 Al2O3 are respectively 16.77% and 21.48% greater at full load than for B20. In terms of hazardous emissions, B20+50 Al2O3 reduced CO emissions by 15.06% compared to B20, while B20+50 CeO2 reduced HC emissions by 50% compared to diesel at peak load. Additionally, at engine peak loads, B20+50 CeO2 Reduces NOx by 18.29% compared to B20. The findings suggest using nano fuel as a diesel oil replacement fuel.
Configuración de atractivos turísticos como patrimonio cultural. El caso de las Termas de Chillán y el viaje en el Tren Chico. Región de Ñuble, Chile: 1911 - 1957
Authors: Cerda Brintrup Gonzalo , Navarrete Muñoz Mónica
Published: May 2023

Tren Chico es el nombre popular otorgado al ramal ferroviario de trocha angosta que conectó Chillán con Recinto en la actual Región de Ñuble, Chile. Su objetivo era llegar a las Termas Minerales, famosas por sus virtudes medicinales, la mitología en torno a las aguas decía que podían curar todo tipo de enfermedades, incluso que eran mucho más efectivas que otras aguas minerales del país y el mundo.

Sin embargo, el acceso a las Termas Minerales, ubicadas en plena cordillera andina era un desafío, principalmente para la población con menor poder adquisitivo, quienes debían realizar largos y difíciles viajes en carretas o a pie, pernoctar a la intemperie, incluso con poca comida, debido a la poca oferta y posibilidades de transportar víveres.

A continuación, se expone un proceso de reconstrucción histórica, donde se analiza el proyecto ferroviario desde inicios del siglo XX a partir de fuentes primarias, considerando las transformaciones espaciales, el desarrollo económico que impulsó, y el posterior cierre del servicio al ser reemplazado por vehículos motorizados a finales del siglo XX.

Se problematiza el abandono de la infraestructura y su lugar en la cultura e identidad territorial, así como la puesta en valor de sus vestigios.
Fuerte de San Rosendo: primeras reflexiones sobre su posible hallazgo
Authors: Milla Sandoval Luis Felipe , Andrade Pedro , Santana Sebastián
Published: May 2023

Los fuertes coloniales ubicados en la cuenca del Biobío, es una de las evidencias tangibles más duraderas de la presencia hispana en Chile. Muchos de estos fuertes se han mantenido hasta hoy, dando origen a ciudades. Otros, por el contrario, han ido desapareciendo de los mapas urbanos actuales. Uno de estos corresponde al Fuerte de San Rosendo, el cual se ha creído por muchos años, fue instalado en la cumbre de un cerro cercano a la ciudad. A partir del reciente hallazgo de una arruinada estructura de piedras en el sector urbano de la comuna, recopilamos fuentes y menciones históricas sobre la fundación, presencia y ubicación del Fuerte de San Rosendo. A partir de este análisis y discusión, planteamos que las ruinas descubiertas presentan un alto potencial de pertenecer al Fuerte de San Rosendo, sin descartar que otras instalaciones militares menores pueden haberse ubicado en los cerros circundantes.
Visión y reflejo de la muerte
Authors: Pincheira Fernández Carolina , Muñoz Ocampo Claudia
Published: May 2023

Se revisan las características del cementerio municipal de Chillán en el contexto que representa la creación de normas que separaban a la iglesia católica de la administración del Estado chileno respecto de la muerte en la ciudad.

La ley de cementerios laicos posee una importan­cia histórica, producto que su promulgación pro­vocó polarización en el país entre quienes eran fieles seguidores de la iglesia católica y los ritos que tradicionalmente esta administraba, y quienes proponían una ideología más liberal, con un control estatal sobre los principales aspectos del quehacer humano, como la muerte.

El estudio describe el proceso normativo que desembocó en la Ley de Cementerios Laicos como herramienta para disminuir la desigualdad en la sociedad chillaneja y las implicancias de la cons­trucción de un cementerio municipal en Chillán.
JURIDICAL ANALYSIS OF HUMANITARIAN FUNDS MANAGEMENT OF PHILANTHROPIC INSTITUTIONS IN INDONESIA CASE STUDY OF FUNDS DETERMINATION IN ACT
Authors: Syafry Firman Muhammad , Isman Isman , Muthoifin Muthoifin
Published: May 2023

Lembaga filantropi islam memiliki peran penting dalam membantu mengatasi masalah sosial ekonomi masyarakat dan mengatasi kemiskinan. Dengan isu kemanusiaan dan kebencanaan menjadikan Aksi Cepat Tanggap (ACT) salah satu Lembaga Filantropi Islam yang paling dipercaya masyarakat untuk mengelola dana umat untuk disalurkan kepada mereka yang berhak menerimanya. Namun dalam beberapa tahun terakhir, terdapat beberapa kasus penyimpangan dana kemanusiaan yang dilaporan di media massa. Salah satu kasus yang cukup kontroversial adalah kasus dugaan, penyimpangan dana kemanusiaan untuk kepentingan pribadi oleh pimpinan lembaga ACT (Aksi Cepat Tanggap). ACT diduga telah menggunakan dana kemanusiaan yang di berikan untuk kepentingan entitas pribadi, aktivitas terlarang (terorisme) dan tidak sesuai dengan peruntukannya. Analisis hukum dilakukan dengan deskriptif kualitatif, metode pendekatan yang digunakan yaitu pendekatan yuridis normatif, pengumpalan data dalam penelitian ini dengan studi kepustakaan (library research). Hasil Penelitian menunjukkan Pengelolaan dana kemanusiaan yang dihimpun oleh Aksi Cepat Tanggap bertentangan dengan Undang-Undang Nomor 9 tahun 1961 tentang Pengumpulan Uang atau Barang yang pelaksanaannya diatur dalam Peraturan Menteri Sosial Nomor 8 tahun 2021, serta Undang-Undang nomor 23 tahun 2011 tentang zakat, karena ACT menghimpun dana kemanusiaan dengan mengatasnamakan Zakat, Infaq dan Shodaqoh namun tidak dikelolam menurut ketentuan Undang-Undang zakat.
FAKTOR KECICIRAN MURID-MURID PROGRAM PEMULIHAN KHAS SEKOLAH RENDAH DI MALAYSIA
Authors: Saidin Nur Faizahton , Mohd Bukhari Nur Azimah
Published: May 2023

The Ministry of Education Malaysia (MOE) has discovered that pupils were falling behind in Malay language literacy and sought to remedy the situation through the implementation of specific measures. This concept paper aims to identify factors that can contribute to that phenomenon among pupils under the “Program Pemulihan Khas” (Special Recovery Programme). Some factors were the impact of the COVID-19 pandemic, poor reading skills and the lack of appropriate usage of “Bahan Bantu Mengajar” (BBM) (teaching aids). Subsequently, the paper elucidates measures executed by various parties, like teachers, schools, MOE and the authorities, to overcome the phenomenon. For instance, the provision of guidance by teachers, the introduction of remedial education programmes and the utilisation of BBMs were employed to sustain the pupils. In conclusion, continuous effort and commitment from all parties are required to propel the education sector in line with globalisation. This study is expected to catalyse deeper research to bridge the educational gap in Malaysia. An examination of the implications of poor literacy on society and the country can be conducted for further research.
TAFSIRAN KESEJAHTERAAN SUBJEKTIF INDIVIDU SEMASA PANDEMIK COVID-19 DI SUNGAI BULOH, SELANGOR
Authors: Nik Mad Nik Shahrizan , Md Yunus Marzudi , Muda Mashrom
Published: May 2023

The level of subjective well-being of individuals was affected by the COVID-19 pandemic. Both economic (objective) and non-economic (subjective) factors needs to be evaluated to assess the levels of individual well-being. The objective of this study is to assess the level of individual wellbeing during the COVID-19 pandemic. This research uses a qualitative approach through interviews to obtain information related to subjective well-being during the COVID-19 pandemic. The study involves 20 participants who were affected during the pandemic, including former patients, family members or individuals in the Control Movement Order areas and those who also underwent quarantine. The findings of this investigation shows that economic, social, educational, religious, as well as physical and mental health effects are related to the increase in well-being. The positive effects are related to the increase in well-being, while the negative effects decrease an individual’s level of happiness. The differences in age, location, and occupation correspondingly have distinctive relationships in the assessment of individual wellbeing levels. The findings of this study can additionally help identify the challenges and effects of the pandemic on patients, serving as a reference for government agencies to improve policies and awareness of well-being levels among communities. Further research can be done by investigating the diversity of geographic areas, involving respondents from different areas such as urban, suburban, and rural areas to provide a more comprehensive picture of subjective wellbeing. Studies on subjective well-being can contribute more comprehensive information and assist policy makers as well as psychologists in developing more effective programs to improve subjective well-being.
SENI BAHASA DALAM LEKA PELIAN BERDASARKAN PERSPEKTIF TEORI METAFORA KONSEPTUAL
Authors: Benson Yanti , Sandai Rosline , Junaidi Rohayati , Banseng Saripah
Published: May 2023

“Leka pelian” is a traditional poem of the Iban community in the invocation category, which is used in traditional Iban healing rituals. Every word sung by the “manang” in “leka pelian” is decorated with figurative language and metaphors to add more beauty to the art of poetry. However, the lack of experts in “leka pelian” makes it difficult for the younger generation, especially the Iban community, to understand the figurative language and metaphors used in “leka pelian” by the “manang”. This has led to the younger generation showing less interest in delving into oral traditions such as “leka pelian”. Therefore, this study aims to analyse the meaning of the metaphors that shapes the “leka pelian” based on the conceptual metaphor theory of Lakoff and Johnson (1980). This study is qualitative and uses the Conceptual Metaphor Theory of Lakoff and Johnson (1980) to analyse the categories of metaphors found in “leka pelian”. Content analysis method is used to analyse each category of metaphor found in “leka pelian”. The findings show that the figurative language in “leka pelian” consists of abstract metaphors to reality, simile metaphors, animal metaphors, nature metaphors, as well as adapted and cultural comparison metaphors in their lives. The investigation shows that nature metaphors are more dominant than other metaphors because they are influenced by the surrounding nature, making nature a metaphor in communication. This category of metaphor is also used as a medium of communication between human world and the supernatural world. The implication of this research shows that the use of different categories of metaphor in “leka pelian” can increase the knowledge of traditional healers and the Iban community, especially in terms of language skills.
Primeras páginas 15(1)
Authors: Research Journal UNED
Published: May 2023

Primeras páginas 15(1) Junio 2023
Nonlinear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix.
Authors: Budda Divakar , Gülave Berfin , Hasselt Johan G. C. van , Lange Elizabeth De
Published: May 2023

Background & purpose Morphine is important for treatment of acute and
chronic pain. However, there is high interpatient variability and often
inadequate pain relief and adverse effects. To better understand
variability in the dose effect relationships of morphine, we
investigated the impact of its nonlinear blood-brain-barrier (BBB)
transport on mu-opioid receptor (μ-OR) occupancy in different CNS
locations, in conjunction with its main metabolites that bind to the
same receptor. Methods CNS exposure profiles for morphine, M3G and M6G
for clinically relevant dosing regimens based on intravenous, oral
immediate- and extended-release formulations were generated using a CNS
PBPK model which incorporated nonlinear BBB transport of morphine. The
simulated CNS exposure profiles were then used to derive corresponding
μ-OR occupancies at multiple CNS pain matrix locations. Results The
simulated CNS exposure profiles for morphine, M3G and M6G, associated
with nonlinear BBB transport of morphine resulted in varying μ-OR
occupancies between the different dose regimens, formulations, and CNS
locations. We find that at lower doses, the μ-OR occupancy of morphine
was relatively higher than at higher doses of morphine, due to the
relative contribution of M3G and M6G. At such higher doses, M6G showed
higher occupancy than morphine, whereas M3G occupancy was low throughout
the dose ranges. Conclusion and implications Nonlinear BBB transport of
morphine influences the μ-OR occupancy ratios of morphine and its
metabolites, depending on dose and route of administration, and CNS
location. This may impact the clinical effects of morphine treatment for
pain relief.
DEVELOPMENT OF AN AUTOMATED STEERABLE RADIO TELESCOPE.
Authors: Dutta Pritam , Saraswat Rushil
Published: May 2023

The paper presents an innovative approach towards the design and construction of a steerable radio telescope with an automated control system. The telescope uses a combination of motors and sensors to steer towards celestial objects of interest, with the ability to track moving targets such as satellites. The authors detail the technical specifications of the telescope, including its radio frequency range, sensitivity, and accuracy, and discuss the challenges encountered during its development.
This research paper is highly relevant to the field of astrophysics as radio telescopes play a critical role in studying the properties of the universe. The development of an automated steerable radio telescope presents new opportunities for data collection and analysis, allowing astronomers to observe the universe more efficiently and effectively. The paper demonstrates the application of physics principles, such as mechanics and electromagnetism, in the design and operation of the telescope. The findings of this study can contribute to further research in astrophysics, including studies of the cosmic microwave background, radio galaxies, and other extragalactic sources. Overall, the development of an automated steerable radio telescope represents a significant advancement in the field of astrophysics and presents new avenues for research and discovery in the coming years.
Research on data mining technology in power marketing system
Authors: meng qi , Zhang Xixiang , yang jun
Published: May 2023

This article starts with the importance of electric power marketing
systems, introduces the technical characteristics of data mining and its
application status in electric power marketing systems, thereby
providing decision-making basis for the economic operation of power
grids. And propose using C5.0 decision tree algorithm to deeply analyze
the marketing data of the electric power marketing management system.
The original C5.0 decision tree algorithm is improved by introducing
information entropy, which improves its classification speed and
accuracy. Experimental results on UCI machine learning dataset and power
marketing dataset show that the proposed improved C5.0 decision tree
algorithm has good classification performance and can meet the
classification and prediction requirements in power marketing work.
Labor Cost Visualization at Carescript: An Introductory Data Analytics Case for Management Accounting
Authors: Loftus Serena , McCoy Sarah Shonka , Valentine Erick G. , West Timothy D.
Published: May 2023

This case introduces students to data visualization by requiring them to analyze labor cost data for a fictional pharmacy. The case enhances students’ understanding of cost behavior by illustrating that an organization’s cost structure can evolve, which highlights the importance of using relevant data. This case is written for students without exposure to data analytics, but it includes suggestions for advanced data analysis. The case can be used in any course that discusses the cost equation. The case can be covered in one class and is adaptable to both online and in-person instruction. Instructors can customize their teaching of the case to further coverage of data analysis techniques or changes to a business’s cost structure. The case includes instructions for generating a new dataset each semester.
Insider Trading in News Deserts
Authors: Kyung Hangsoo , Nam Jonathan Sangwook
Published: May 2023

This study examines the informational value of local news outlets and how they affect insider trading. We hypothesize that local news coverage is a critical channel through which outsiders acquire local information, which restricts insiders’ ability to profit from their information advantage. We argue that a loss of local news coverage increases information opacity faced by outsiders, while making it easier for insiders to seize profitable trading opportunities. Exploring the staggered shutdown of local newspapers, our difference-in-differences estimation presents novel evidence that insiders from closure counties trade more profitably after local newspaper closures, particularly in small firms that lack alternative news sources. Further analyses reaffirm that the post-closure increase in trading profits is unlikely to be wholly driven by regional economic conditions and is likely driven by increased information costs. Our results highlight that local newspapers play a meaningful role in mitigating information asymmetry between insiders and outsiders.

Data Availability: Data used in this study are available from the sources identified in the paper.

JEL Classifications: G14; G30; L82.
The Demand for Internal Auditors following Accounting and Operational Failures
Authors: Ege Matthew S. , Kim Young Hoon , Wang Dechun
Published: May 2023

Using a comprehensive database of U.S. internal auditor job postings, we find that firms are about 10 percent more likely to post an internal auditor job after the revelation of accounting and operational failures. Also, the demand for internal auditors is stronger when a failure is more severe. Among firms posting internal auditor jobs, firms demand higher-quality internal auditors in response to a failure compared with when there has not been a recent failure. We find evidence of internal audit demand spillovers through connected directors, which helps mitigate concerns that the primary results are due to replacing internal auditors that recently left or due to endogenous links between hiring internal auditors and failure revelations. Overall, our evidence suggests that firms demand internal auditors to help ensure high-quality financial reporting and effective operations.

JEL Classifications: G34, J23, M41, M42.
Loss of cAMP signaling in CD11c immune cells protects against diet-induced obesity
Authors: Zeng Liping , Scott Herdman D. , Min Lee Sung , Tao Ailin , Das Manasi , Bertin Samuel , Eckmann Lars , Mahata Sushil , Wu Panyisha , Hara Miki , Byun Ji-Won , Devulapalli Shwetha , H. Patel Hemal , J.A. Molina Anthony , Osborn Olivia , Corr Maripat , Raz Eyal , J.G. Webster Nicholas
Published: May 2023

In obesity, CD11c+ innate immune cells are recruited to adipose tissue and create an inflammatory state that causes both insulin and catecholamine resistance. We found that ablation of Gnas, the gene that encodes Gas, in CD11c expressing cells protects mice from obesity, glucose intolerance, and insulin resistance. Transplantation studies showed that the lean phenotype was conferred by bone marrow-derived cells and did not require adaptive immunity. Loss of cAMP signaling was associated with increased adipose tissue norepinephrine and cAMP signaling, and prevention of catecholamine resistance. The adipose tissue had reduced expression of catecholamine transport and degradation enzymes suggesting that the elevated norepinephrine resulted from decreased catabolism. Collectively, our results identified an important role for cAMP signaling in CD11c+ innate immune cells in whole-body metabolism by controlling norepinephrine levels in WAT, modulating catecholamine-induced lipolysis, and increasing thermogenesis, which together created a lean phenotype.