bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
Authors: Jang Hochung , Kim Eun Hye , Chi Sung-Gil , Kim Sun Hwa , Yang Yoosoo
Published: September 2021

A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.
The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions
Authors: Parcerisas Antoni , Ortega-Gascó Alba , Pujadas Lluís , Soriano Eduardo
Published: September 2021

Although it has been over 20 years since Neural Cell Adhesion Molecule 2 (NCAM2) was identified as the second member of the NCAM family with a high expression in the nervous system, the knowledge of NCAM2 is still eclipsed by NCAM1. The first studies with NCAM2 focused on the olfactory bulb, where this protein has a key role in axonal projection and axonal/dendritic compartmentalization. In contrast to NCAM1, NCAM2’s functions and partners in the brain during development and adulthood have remained largely unknown until not long ago. Recent studies have revealed the importance of NCAM2 in nervous system development. NCAM2 governs neuronal morphogenesis and axodendritic architecture, and controls important neuron-specific processes such as neuronal differentiation, synaptogenesis and memory formation. In the adult brain, NCAM2 is highly expressed in dendritic spines, and it regulates synaptic plasticity and learning processes. NCAM2’s functions are related to its ability to adapt to the external inputs of the cell and to modify the cytoskeleton accordingly. Different studies show that NCAM2 interacts with proteins involved in cytoskeleton stability and proteins that regulate calcium influx, which could also modify the cytoskeleton. In this review, we examine the evidence that points to NCAM2 as a crucial cytoskeleton regulation protein during brain development and adulthood. This key function of NCAM2 may offer promising new therapeutic approaches for the treatment of neurodevelopmental diseases and neurodegenerative disorders.
Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice
Authors: Lee Kippeum , Kim Jisoo , Park Soo-Dong , Shim Jae-Jung , Lee Jung-Lyoul
Published: September 2021

Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person’s quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can improve muscle mass and muscle strength and affect physical performance. Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The present research shows that L. plantarum HY7715 increases physical performance and skeletal muscle mass in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging.
SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways
Authors: Liu Lu , Li Qiqi , Yang Liu , Li Qifa , Du Xing
Published: September 2021

TGF-β family signaling pathways, including TGF-β and BMP pathways, are widely involved in the regulation of health and diseases through downstream SMADs, which are also regulated by multiple validated mechanisms, such as genetic regulation, epigenetic regulation, and feedback regulation. However, it is still unclear whether R-SMADs or Co-SMAD can feedback regulate the TGF-β family signaling pathways in granulosa cells (GCs). In this study, we report a novel mechanism underlying the feedback regulation of TGF-β family signaling pathways, i.e., SMAD4, the only Co-SMAD, positive feedback activates the TGF-β family signaling pathways in GCs with a basal level of TGF-β ligands by interacting with the core promoters of its upstream receptors. Mechanistically, SMAD4 acts as a transcription factor, and feedback activates the transcription of its upstream receptors, including ACVR1B, BMPR2, and TGFBR2, of the canonical TGF-β signaling pathways by interacting with three coactivators (c-JUN, CREB1, and SP1), respectively. Notably, three different interaction modes between SMAD4 and coactivators were identified in SMAD4-mediated feedback regulation of upstream receptors through reciprocal ChIP assays. Our findings in the present study indicate for the first time that SMAD4 feedback activates the canonical TGF-β family signaling pathways in GCs, which improves and expands the regulatory mechanism, especially the feedback regulation modes of TGF-β family signaling pathways in ovarian GCs.
Mineralocorticoid Receptor Antagonists—Use in Chronic Kidney Disease
Authors: Baran Wiktoria , Krzemińska Julia , Szlagor Magdalena , Wronka Magdalena , Młynarska Ewelina , Franczyk Beata , Rysz Jacek
Published: September 2021

Mineralocorticoid receptor antagonists (MRA) are drugs with a potentially broad spectrum of action. They have been reported to have healing effects in many diseases, such as chronic heart failure, hypertension, or nephrotic syndrome. Numerous studies suggest that mineralocorticoid receptor activation is pathogenic and a progression factor of chronic kidney disease (CKD); however, results of studies on the use of MRA in the treatment of CKD are inconclusive. Current guidelines recommend against the use of MRA in patients with advanced CKD. Although, there is growing interest on their use in this population due to treatment benefits. In this review, we summarize studies which were purposed to evaluate the impact of MRA therapy on CKD patients. Despite many benefits of this treatment e.g., reducing cardiovascular mortality or alleviating proteinuria, steroidal MRA (such as spironolactone or eplerenone) have a low safety profile. They often lead to hyperkalemia complications which are dangerous in patients with CKD, and diabetic nephropathy, especially in hemodialysis patients. Studies on recently developed nonsteroidal MRA showed that they have fewer side effects. In our review, we discuss steroidal and nonsteroidal MRA treatment effects on the estimated glomerular filtration rate (eGFR), proteinuria, the cardiovascular system, and hyperkalemia in CKD patients. We present new content and recent publications in this field.
Collagen XV Promotes ER Stress-Induced Inflammation through Activating Integrin β1/FAK Signaling Pathway and M1 Macrophage Polarization in Adipose Tissue
Authors: Li Changxing , Liu Yuexia , Li Yizhou , Tai Ruiqing , Sun Zhuwen , Wu Qiong , Liu Yongnian , Sun Chao
Published: September 2021

Collagen XV (Col XV), a basement membrane (BM) component, is highly expressed in adipose tissue, and studies have found that Col XV is related to extracellular matrix (ECM) remodeling involving in adipose tissue fibrosis and inflammation. Furthermore, the ECM is essential for maintaining normal development and tissue function. In this study, we found that Col XV is related to the endoplasmic reticulum stress (ERS) and inflammation of adipose tissue. Moreover, we found that overexpression of Col XV in mice could cause macrophages to infiltrate white adipose tissue (iWAT). At the same time, the expression of the ERS sensor IRE1α (Inositol-Requiring Enzyme-1α) was significantly up-regulated, which intensified the inflammation of adipose tissue and the polarization of M1 macrophages after the overexpression of Col XV in mice. In addition, after overexpression of Col XV, the intracellular Ca2+ concentration was significantly increased. Using focal adhesion kinase (FAK) inhibitor PF573228, we found that PF-573228 inhibited the phosphorylation of FAK and reversed the upward trend of Col XV-induced protein expression levels of IRE1α, C/EBP-homologous protein (CHOP), and 78 kDa glucose-regulated protein (GRP78). After treatment with IRE1α inhibitor STF-083010, the results showed that the expression of adipocyte inflammation-related genes interleukin 6 (IL-6) and tumor necrosis factor α (TNFα) significantly were decreased. Our results demonstrate that Col XV induces ER-stress in adipocytes by activating the Integrinβ1/FAK pathway and disrupting the intracellular Ca2+ balance. At the same time, Col XV regulates the inflammation induced by ER stress in adipocytes by promoting IRE1α/XBP1 (X-Box binding protein 1) signaling. Our study provides new ideas for solving the problems of adipose tissue metabolism disorders caused by abnormal accumulation of ECM.
The Effects of Temperature on the Development, Morphology, and Fecundity of Aenasius bambawalei (=Aenasius arizonensis)
Authors: Zhang Juan , Tang Yayuan , Huang Jun
Published: September 2021

The effects of high temperature on the developmental, morphological, and fecundity characteristics of insects, including biological invaders and their accompanying natural enemies, are clear. Phenacoccus solenopsis (Homoptera: Pseudococcidae) is an aggressive invasive insect pest worldwide. Aenasius bambawalei (=Aenasius arizonensis Girault) (Hymenoptera: Encyrtidae) is a predominant accompanying parasitoid of this mealybug. Our previous studies showed that temperature change induced an increase in the female offspring ratio of A. bambawalei. However, whether this increase is the result of a shortened or enhanced development period of the reproductive systems of A. bambawalei remains unknown. Here, we compared the pupal development, hind tibia of female adults, and fecundity of A. bambawalei under different temperatures to clarify the development and morphological changes induced by high temperature and to better understand its potential as an accompanying natural enemy. Our results showed that, at a high temperature (36 °C), the pupal developmental duration of A. bambawalei was only 0.80 times that of the control, and the length of the hind tibia was 1.16 times that of the control. Moreover, high temperature accelerated the developmental rate of gonads and increased the numbers of eggs and sperm. These results indicated that experimental warming shortened the pupal developmental duration, altered the hind tibia length of female adults, and facilitated the fecundity of A. bambawalei. These findings will help to understand the adaptation mechanisms of accompanying natural enemies. Furthermore, these findings will help to make use of this behavior to effectively control invasive pests.
Impact of the Coronavirus Disease-2019 Pandemic on Pancreaticobiliary Disease Detection and Treatment
Authors: Ikemura Muneo , Tomishima Ko , Ushio Mako , Takahashi Sho , Yamagata Wataru , Takasaki Yusuke , Suzuki Akinori , Ito Koichi , Ochiai Kazushige , Ishii Shigeto , Saito Hiroaki , Fujisawa Toshio , Nagahara Akihito , Isayama Hiroyuki
Published: September 2021

The emergency declaration (ED) associated with the coronavirus disease-2019 (COVID-19) pandemic in Japan had a major effect on the management of gastrointestinal endoscopy. We retrospectively compared the number of pancreaticobiliary endoscopies and newly diagnosed pancreaticobiliary cancers before (1 April 2018 to 6 April 2020), during (7 April to 25 May 2020), and after the ED (26 May to 31 July). Multiple comparisons of the three groups were performed with respect to the presence or absence of symptoms and clinical disease stage. There were no significant differences among the three groups (Before/During/After the ED) in the mean number of diagnoses of pancreatic cancer and biliary cancer per month in each period (8.0/7.5/7.5 cases, p = 0.5, and 4.0/3.5/3.0 cases, p = 0.9, respectively). There were no significant differences among the three groups in the number of pancreaticobiliary endoscopies (EUS: endoscopic ultrasonography/ERCP: endoscopic retrograde cholangiopancreatography) per month (67.8/62.5/69.0 cases, p = 0.7 and 89.8/51.5/86.0 cases, p = 0.06, respectively), whereas the number of EUS cases decreased by 42.7% between before and during the ED. There were no significant differences among the three groups in the presence or absence of symptoms at diagnosis or clinical disease stage. There was no significant reduction in the newly diagnosed pancreaticobiliary cancer, even during the ED. The number of ERCP cases was not significantly reduced as a result of urgent procedures, but the number of EUS cases was significantly reduced.
Occupational Exposure and Multiple Myeloma Risk: An Updated Review of Meta-Analyses
Authors: Georgakopoulou Rebecca , Fiste Oraianthi , Sergentanis Theodoros N. , Andrikopoulou Angeliki , Zagouri Flora , Gavriatopoulou Maria , Psaltopoulou Theodora , Kastritis Efstathios , Terpos Evangelos , Dimopoulos Meletios A.
Published: September 2021

The precise etiology of multiple myeloma remains elusive, but both genetic and environmental factors have been suggested to contribute to disease risk. Several occupational categories and toxic agents have been implicated as potentially causative, yet findings from the literature are inconsistent. The aim of this review was to summarize and critically comment on the accumulated epidemiological evidence, across published meta-analyses, about the association between occupational exposure and risk of multiple myeloma. Overall, results from eleven meta-epidemiological studies underscore a significantly increased risk for firefighters, hairdressers, and employees exposed to engine exhaust, whereas farming and methylene chloride exposure have been non-significantly correlated with the disease. Further epidemiological studies are of utmost importance whilst emphasis should be placed on occupational hazard surveillance, as such studies will obtain a more accurate picture of disease occurrence in working populations, and will enable both the implementation of preventive actions and the evaluation of their effectiveness.
Effects of Clonidine as an Adjuvant to Lidocaine with Epinephrine in Ultrasound Guided Axillary Brachial Plexus Block: A Randomised Controlled Trial
Authors: Ranganath Anil , Hitka Tomas , Iohom Gabriella
Published: September 2021

This study evaluated the effects of adding adjuvant clonidine to lidocaine with epinephrine on the characteristics of ultrasound-guided axillary brachial plexus block (ABPB) for upper extremity surgery. Twenty-four patients were randomised to receive an ultrasound guided ABPB with 20 mL of lidocaine 2% with 1:200,000 epinephrine plus 2 mL of either normal saline 0.9% (Group 1) or a mixture of clonidine 1 µg/kg and normal saline 0.9% (Group 2). The outcome measures that were recorded were the overall onset time and the duration of sensory and motor block. The median (IQR) overall onset time of sensory and motor block was significantly shorter in Group 2 vs. Group 1 (5 (5–7.5) min vs. 10 (8.8–12.5) min; p < 0.001) and (5 (2.5–7.5) min vs. 7.5 (6.3–7.5) min; p = 0.001), respectively. The median (IQR) overall duration of sensory and motor block was significantly longer in Group 2 vs. Group 1 (225 (200–231) min vs. 168 (148–190) min; p < 0.001) and (225 (208–231) min vs. 168(148–186) min; p < 0.001), respectively. In ultrasound-guided ABPB, the addition of clonidine to lidocaine with epinephrine resulted in shorter onset time and prolonged duration of sensory and motor block.
Comparison of Dental Surface Image Registration and Fiducial Marker Registration: An In Vivo Accuracy Study of Static Computer-Assisted Implant Surgery
Authors: Han Yen-Ting , Lin Wei-Chun , Fan Fang-Yu , Chen Chih-Long , Lin Chia-Cheng , Cheng Hsin-Chung
Published: September 2021

This study compared the accuracy of static computer-assisted implant surgery (sCAIS) planned through dental surface image registration and fiducial marker registration. Stone models of 30 patients were converted into digital dental casts by using a desktop scanner. Cone-beam computed tomography (CBCT) was performed and superimposed to the digital dental casts with two methods: matching the dental surface images or matching the fiducial markers on a stereolithographic radiographic template. Following the implant planning, stereolithographic surgical guides were fabricated, and 56 fully guided implants were inserted by the same doctor. Deviations between planned and inserted implants were measured and compared using postoperative CBCT images. After adjustment for other potential influencing factors, compared with the fiducial marker registration group, significantly larger mean lateral deviations were noted in the dental surface registration group at both the implant platform and apex (p = 0.0188 and 0.0371, respectively). However, the mean lateral deviations for the dental surface registration (0.83 ± 0.51 mm at implant platform and 1.24 ± 0.68 mm at implant apex) were comparable to the literature. In conclusion, our findings indicate that although sCAIS planned using dental surface image registration was not statistically as accurate as that using fiducial marker registration, its accuracy was satisfactory for clinical use.
Metabolic Reprogramming and Host Tolerance: A Novel Concept to Understand Sepsis-Associated AKI
Authors: Toro Juan , Manrique-Caballero Carlos L. , Gómez Hernando
Published: September 2021

Acute kidney injury (AKI) is a frequent complication of sepsis that increases mortality and the risk of progression to chronic kidney disease. However, the mechanisms leading to sepsis-associated AKI are still poorly understood. The recognition that sepsis induces organ dysfunction in the absence of overt necrosis or apoptosis has led to the consideration that tubular epithelial cells (TEC) may deploy defense mechanisms to survive the insult. This concept dovetails well with the notion that the defense against infection does not only depend on the capacity of the immune system to limit the microbial load (known as resistance), but also on the capacity of cells and tissues to limit tissue injury (known as tolerance). In this review, we discuss the importance of TEC metabolic reprogramming as a defense strategy during sepsis, and how this cellular response is likely to operate through a tolerance mechanism. We discuss the fundamental role of specific regulatory nodes and of mitochondria in orchestrating this response, and how this opens avenues for the exploration of targeted therapeutic strategies to prevent or treat sepsis-associated AKI.
Medically Serious Suicide Attempts in Personality Disorders
Authors: Quesada-Franco Marta , Pintor-Pérez Luis , Daigre Constanza , Baca-García Enrique , Ramos-Quiroga Josep Antoni , Braquehais María Dolores
Published: September 2021

Medically serious suicide attempts (MSSA) represent a subgroup of clinically heterogeneous suicidal behaviors very close to suicides. Personality disorders (PD) are highly prevalent among them, together with affective and substance use disorders. However, few studies have specifically analyzed the role of PD in MSSA. These suicide attempts (SA) are usually followed by longer hospitalization periods and may result in severe physical and psychological consequences. The aim of this study is to compare the profile of MSSA patients with and without PD. MSSA were defined according to Beautrais ‘criteria, but had to remain hospitalized ≥48 h. Overall, 168 patients from two public hospitals in Barcelona were evaluated during a three-year period. Mean hospital stay was 23.68 (standard deviation (SD) = 41.14) days. Patients with PD (n = 69) were more likely to be younger, female, make the first and the most serious SA at a younger age, reported recent stressful life-events and more frequently had previous suicide attempts compared to those without PD. However, no differences were found with regards to comorbid diagnoses, current clinical status, features of the attempt, or their impulsivity and hopelessness scores. Therefore, focusing on the subjective, qualitative experiences related to MSSA among PD patients may increase understanding of the reasons contributing to these attempts in order to improve prevention strategies in the future.
Elevated Plasma Soluble PD-L1 Levels in Out-of-Hospital Cardiac Arrest Patients
Authors: Sumiyoshi Miho , Kawamoto Eiji , Nakamori Yuki , Esumi Ryo , Ikejiri Kaoru , Shinkai Toru , Akama Yuichi , Ito-Masui Asami , Imai Hiroshi , Gaowa Arong , Park Eun Jeong , Shimaoka Motomu
Published: September 2021

Background: A deregulated immune system has been implicated in the pathogenesis of post-cardiac arrest syndrome (PCAS). A soluble form of programmed cell death-1 (PD-1) ligand (sPD-L1) has been found at increased levels in cancer and sustained inflammation, thereby deregulating immune functions. Here, we aim to study the possible involvement of sPD-L1 in PCAS. Methods: Thirty out-of-hospital cardiac arrest (OHCA) patients consecutively admitted to the ER of Mie University Hospital were prospectively enrolled. Plasma concentrations of sPD-L1 were measured by an enzyme-linked immunosorbent assay in blood samples of all 30 OHCA patients obtained during cardiopulmonary resuscitation (CPR). In 13 patients who achieved return-of-spontaneous-circulation (ROSC), sPD-L1 levels were also measured daily in the ICU. Results: The plasma concentrations of sPD-L1 in OHCA were significantly increased; in fact, to levels as high as those observed in sepsis. sPD-L1 levels during CPR correlated with reduced peripheral lymphocyte counts and increased C-reactive protein levels. Of 13 ROSC patients, 7 cases survived in the ICU for more than 4 days. A longitudinal analysis of sPD-L1 levels in the 7 ROSC cases revealed that sPD-L1 levels occurred in parallel with organ failure. Conclusions: This study suggests that ischemia- reperfusion during CPR may aberrantly activate immune and endothelial cells to release sPD-L1 into circulation, which may play a role in the pathogenesis of immune exhaustion and organ failures associated with PCAS.
Correlation of Panoramic Radiography, Cone-Beam Computed Tomography, and Three-Dimensional Printing in the Assessment of the Spatial Location of Impacted Mandibular Third Molars
Authors: Jaroń Aleksandra , Gabrysz-Trybek Ewa , Bladowska Joanna , Trybek Grzegorz
Published: September 2021

The development of radiology, rapid prototyping techniques, and the increasingly common use of 3D printing in dentistry inspires the use of these techniques to improve diagnostic and therapeutic processes. This study aimed to conduct a retrospective comparative analysis of dental panoramic radiographs, cone-beam computed tomography, and 3D printing in preoperative assessment of the procedure’s difficulty. Thirty clinical cases with a high degree of difficulty were selected, and based on evaluation with CBCT, a virtual 3D model of the region of surgical procedure was created, which was then printed using a 3D printer. The comparative analysis included the linear measurements performed in dental panoramic radiographs, cone-beam computed tomography, and 3D models in a preoperative assessment of the degree of retention and difficulty of impacted mandibular third molars in the mandible. Linear measurements performed on dental panoramic radiographs were significantly lower than in cone-beam computed tomography and 3D models. No statistically significant differences were obtained in linear measurements between 3D models and cone-beam computed tomography images except for the measurement of the lingual lamina thickness; however, due to the insignificant differences in measurements, with a mean of only 80 µm, the elective procedure of removal of the impacted third molar in the mandible may be safe.
Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor
Authors: Alavi Parnian , Rathod Abhisha M. , Jahroudi Nadia
Published: September 2021

Endothelial cells that cover the lumen of all blood vessels have the inherent capacity to express both pro and anticoagulant molecules. However, under normal physiological condition, they generally function to maintain a non-thrombogenic surface for unobstructed blood flow. In response to injury, certain stimuli, or as a result of dysfunction, endothelial cells release a highly adhesive procoagulant protein, von Willebrand factor (VWF), which plays a central role in formation of platelet aggregates and thrombus generation. Since VWF expression is highly restricted to endothelial cells, regulation of its levels is among the most important functions of endothelial cells for maintaining hemostasis. However, with aging, there is a significant increase in VWF levels, which is concomitant with a significant rise in thrombotic events. It is not yet clear why and how aging results in increased VWF levels. In this review, we have aimed to discuss the age-related increase in VWF, its potential mechanisms, and associated coagulopathies as probable consequences.
Renal Outcome of IgM Nephropathy: A Comparative Prospective Cohort Study
Authors: Chae Yura , Yoon Hye Eun , Chang Yoon Kyung , Kim Young Soo , Kim Hyung Wook , Choi Bum Soon , Park Cheol Whee , Song Ho Cheol , Kim Young Ok , Koh Eun Sil , Chung Sungjin
Published: September 2021

Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulonephritis characterized by diffuse deposits of IgM in the glomerular mesangium. However, its renal prognosis remains unknown. We compared renal outcomes of IgMN patients with those of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or mesangial proliferative glomerulonephritis (MsPGN) from a prospective observational cohort, with 1791 patients undergoing native kidney biopsy in eight hospitals affiliated with The Catholic University of Korea between December 2014 and October 2020. IgMN had more mesangial proliferation and matrix expansion than MsPGN and more tubular atrophy and interstitial fibrosis than MCD. IgMN patients had decreased eGFR than MCD patients in the earlier follow-up. However, there was no significant difference in urine protein or eGFR among all patients at the last follow-up. When IgMN was divided into three subtypes, patients with FSGS-like IgMN tended to have lower eGFR than those with MCD-like or MsPGN-like IgMN but higher proteinuria than MsPGN-like IgMN without showing a significant difference. The presence of hypertension at the time of kidney biopsy predicted ≥20% decline of eGFR over two years in IgMN patients. Our data indicate that IgMN would have a clinical course and renal prognosis similar to MCD, FSGS, and MsPGN.
How to Protect Ovarian Function before and during Chemotherapy?
Authors: Arecco Luca , Ruelle Tommaso , Martelli Valentino , Boutros Andrea , Latocca Maria Maddalena , Spinaci Stefano , Marrocco Camilla , Massarotti Claudia , Lambertini Matteo
Published: September 2021

A significant number of women receive a cancer diagnosis before their age of natural menopause. Among these patients, the most frequent neoplasms are breast cancer, gynecological, and hematological malignancies. Premature ovarian insufficiency and infertility are among the most feared short- to long-term consequences of anticancer treatments in premenopausal patients. Both patient- and treatment-related characteristics are key factors in influencing the risk of gonadotoxicity with the use of chemotherapy. The cryopreservation of oocytes/embryos is a standard strategy for fertility preservations offered to young women interested in future family planning, but it does not allow gonadal function protection during chemotherapy. Ovarian suppression with gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy is now recommended as an option to reduce the risk of gonadotoxicity in order to avoid the negative consequences of premature ovarian insufficiency in premenopausal women receiving cytotoxic therapy, including those not interested in fertility preservation. This review summarizes the risk of treatment-induced gonadotoxicity in premenopausal patients and the evidence available on the protective role of administering GnRHa during chemotherapy to preserve ovarian function.
Opioid-Induced Constipation in Patients with Cancer Pain in Japan (OIC-J Study): A Post Hoc Analysis
Authors: Tokoro Akihiro , Imai Hisao , Fumita Soichi , Harada Toshiyuki , Noriyuki Toshio , Gamoh Makio , Okamoto Masaharu , Akashi Yusaku , Kizawa Yoshiyuki
Published: September 2021

Opioid-induced constipation (OIC) can limit the clinical benefit of opioid treatment. This post-hoc analysis evaluated the association between the Rome IV diagnostic criteria and other measures for OIC, including the Bowel Function Index (BFI), correlation between demographics and OIC onset, impact of OIC on pain treatment, and impact of patient–healthcare professional (HCP) communication on patient satisfaction. Patients recorded bowel habits in paper diaries for 14 days following opioid initiation. Study-specific questionnaires were used to evaluate patient awareness of OIC and satisfaction. Patients were ≥20 years old, initiating strong opioid therapy for cancer pain, had an ECOG PS ≤ 2, and had no constipation (≥3 bowel movements within 7 days of enrollment). A total of 220 patients were enrolled. The sensitivity and specificity of BFI for identifying OIC were 81.2% and 54.7%, respectively. Age <65 versus ≥65 years (odds ratio (OR) = 0.510, 95% confidence interval (CI): 0.267–0.977) and the presence or absence of comorbidities (OR = 0.443, 95% CI: 0.221–0.885) were correlated with OIC onset. The proportion of inpatients with sustainable pain control at week 2 was similar in patients with or without OIC (60.0% vs. 67.2%, respectively). By patient assessment, there was a significant correlation between an adequate level of patient–HCP communication and satisfaction with OIC treatment (OR = 9.538 (95% CI: 1.577–57.681)). Using BFI to screen for OIC represents a valid approach in patients with cancer pain. Patient–HCP communication is essential for effective management of OIC in patients with cancer pain.
Indirect Self-Destructiveness in Hidradenitis Suppurativa Patients
Authors: Głowaczewska Amelia , Reszke Radomir , Szepietowski Jacek C. , Matusiak Łukasz
Published: September 2021

Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that negatively affects patients’ quality of life. Indirect self-destructiveness refers to activities extended over time, such as addictions, risky behaviors, neglects, resignation, helplessness. These can be an additional factor impeding the achievement of positive clinical effects in the treatment of HS patients, therefore the objective of the study was to assess the indirect self-destructive behaviors in patients suffering from HS. The study group involved 100 adult HS patients with 59 males and 41 females. Indirect self-destructiveness was investigated with the Polish version of the Kelley’s Indirect Self-Destructiveness Scale (CS-DS). The study revealed that the average total score of indirect self-destructiveness in HS population was 130.16 ± 21.3 (median 128 points). The CS-DS scores were significantly higher in smoking patents (p = 0.006). The most expressed class of indirect self-destructiveness was A5 (Helplessness and Passivity). The indicated results pointed out a strong domination of passive forms of indirect self-destructiveness over its active forms. Due to related low self-esteem, social isolation and exclusion, HS patients are more prone to behave in a self-destructive manner, which may lead to poor health maintenance in a form of leaving appointments and non-adherence.
The Impact of Diagnostic Ureteroscopy Prior to Radical Nephroureterectomy on Oncological Outcomes in Patients with Upper Tract Urothelial Carcinoma: A Comprehensive Systematic Review and Meta-Analysis
Authors: Nowak Łukasz , Krajewski Wojciech , Chorbińska Joanna , Kiełb Paweł , Sut Michał , Moschini Marco , Teoh Jeremy , Mori Keiichiro , Del Giudice Francesco , Laukhtina Ekaterina , Lonati Chiara , Kaliszewski Krzysztof , Małkiewicz Bartosz , Szydełko Tomasz
Published: September 2021

Background: The incidence of intravesical recurrence (IVR) following radical nephroureterectomy (RNU) is reported in up to 50% of patients with upper tract urothelial carcinoma (UTUC). It was suggested that preoperative diagnostic ureteroscopy (URS) could increase the IVR rate after RNU. However, the available data are often conflicting. Thus, in this systematic review and meta-analysis we sought to synthesize available data for the impact of pre-RNU URS for UTUC on IVR and other oncological outcomes. Materials and methods: A systematic literature search of the PubMed, Embase, and Cochrane Library databases was performed in June 2021. Cumulative analyses of hazard ratios (HRs) and their corresponding 95% confidence intervals (CI) were conducted. The primary endpoint was intravesical recurrence-free survival (IVRFS), with the secondary endpoints being cancer-specific survival (CSS), overall survival (OS), and metastasis-free survival (MFS). Results: Among a total of 5489 patients included in the sixteen selected papers, 2387 (43.4%) underwent diagnostic URS before RNU and 3102 (56.6%) did not. Pre-RNU diagnostic URS was significantly associated with worse IVRFS after RNU (HR = 1.44, 95% CI: 1.29–1.61, p < 0.001) than RNU alone. However, subgroup analysis including patients without biopsy during URS revealed no significant impact of diagnostic URS on IVRFS (HR = 1.28, 95% CI: 0.90–1.80, p = 0.16). The results of other analyses showed no significant differences in CSS (HR = 0.94, p = 0.63), OS (HR: 0.94, p = 0.56), and MFS (HR: 0.91, p = 0.37) between patients who underwent URS before RNU and those who did not. Conclusions: The results of this meta-analysis confirm that diagnostic URS prior to RNU is significantly associated with worse IVRFS, albeit with no concurrent impact on the other long-term survival outcomes. Our results indicate that URS has a negative impact on IVRFS only when combined with endoscopic biopsy. Future studies are warranted to assess the role of immediate postoperative intravesical chemotherapy in patients undergoing biopsy during URS for suspected UTUC.
Effects of Perioperative Inflammatory Response in Cervical Cancer: Laparoscopic versus Open Surgery
Authors: Sim Ji-Hoon , Lee Ju-Seung , Jang Dong-Min , Kim Hwa Jung , Lee Shin-Wha , Cho Hyun-Seok , Choi Woo-Jong
Published: September 2021

There are few studies between postoperative neutrophil to lymphocyte ratio (NLR) and survival in cervical cancer. We compared postoperative changes in NLR according to surgical methods and analyzed the effect of these changes on 5-year mortality of cervical cancer patients. A total of 929 patients were assigned to either the laparoscopic radical hysterectomy (LRH) (n = 721) or open radical hysterectomy (ORH) (n = 208) group. Propensity score matching analysis compared the postoperative NLR changes between the two groups, and multivariate logistic regression analysis evaluated the association between NLR changes and 5-year mortality. Surgical outcomes between the two groups were also compared. In the LRH group, NLR changes at postoperative day (POD) 0 and POD 1 were significantly lower than in the ORH group after matching (NLR change at POD 0, 10.4 vs. 14.3, p < 0.001; NLR change at POD 1, 3.5 vs. 5.4, p < 0.001). In multivariate logistic regression analysis, postoperative NLR change was not associated with 5-year mortality (2nd quartile: OR 1.55, 95% CI 0.56–4.29, p = 0.401; 3rd quartile: OR 0.90, 95% CI 0.29–2.82, p = 0.869; 4th quartile: OR 1.40, 95% CI 0.48–3.61, p = 0.598), whereas preoperative NLR was associated with 5-year mortality (OR 1.23, 95% CI 1.06–1.43, p = 0.005). After matching, there were no significant differences in surgical outcomes between the two groups. There were significantly fewer postoperative changes of NLR in the LRH group. However, the extent of these NLR changes was not associated with 5-year mortality. By contrast, preoperative NLR was associated with 5-year mortality.
Higher-Order Language Dysfunctions in Individuals with Alcohol Use Disorder
Authors: Karabanowicz Ewa , Tyburski Ernest , Karasiewicz Karol , Bober Adrianna , Sagan Leszek , Mak Monika , Radziwiłłowicz Wioletta
Published: September 2021

Patients with alcohol use disorders (AUD) have difficulties with certain aspects of higher-order language functions (HOLF) but there is no data on a wide range of these functions in this group. Therefore, the aim of this study was to compare different aspects of HOLF in patients with AUD and healthy controls (HC). A total of 31 patients with AUD and 44 HC took part in the study. We assessed HOLF with the Right Hemisphere Language Battery (RHLB) and measured control variables: depression using the Patient Health Questionnaire (PHQ) as well as the speed of processing and executive functions with the Color Trails Test (CTT). Patients with AUD had lower results on nine RHLB tests. Moreover, AUD patients had higher scores on PHQ and longer reaction times on CTT. The differences in most RHLB results remained significant after co-varying the control variables. Patients with AUD have difficulties with making inferences from the text, understanding the meaning of individual words, metaphorical content, and prosody, which may impede the comprehension and production of discourse in which linguistic elements must be integrated with non-verbal cues and contextual information. These disturbances may impact various spheres of everyday life and negatively influence social, private, and professional functioning.
Assessment of Coronary Inflammation by Pericoronary Fat Attenuation Index in Clinically Suspected Myocarditis with Infarct-Like Presentation
Authors: Baritussio Anna , Vacirca Francesco , Ocagli Honoria , Tona Francesco , Pergola Valeria , Motta Raffaella , Marcolongo Renzo , Lorenzoni Giulia , Gregori Dario , Iliceto Sabino , Caforio Alida L. P.
Published: September 2021

Background: The pathophysiology of angina-like symptoms in myocarditis is still unclear. Perivascular fat attenuation index (pFAI) by coronary computed tomography angiography (CCTA) is a non-invasive marker of coronary inflammation (CI) in atherosclerosis. We explored the presence of CI in clinically suspected myocarditis with infarct-like presentation. Methods: We retrospectively included 15 consecutive patients (67% male, age 30 ± 10 years) with clinically suspected infarct-like myocarditis who underwent CCTA to rule out coronary artery disease. Right coronary artery (RCA) pFAI mean value was compared with that of healthy volunteers. Results: Mean RCA pFAI value was −92.8 ± 8.4 HU, similar to that of healthy volunteers (−95.2 ± 6.0, p = 0.8). We found no correlation between RCA pFAI mean values and peak Troponin I (r = −0.43, p = 0.11) and C-reactive protein at diagnosis (r = −0.25, p = 0.42). Patients with higher pFAI values showed higher biventricular end-systolic volumes (ESV) (p = 0.038 for left and p = 0.024 for right ventricle) and lower right ventricular ejection fraction (RVEF) (p = 0.038) on cardiovascular magnetic resonance. Conclusions: In clinically suspected myocarditis with infarct-like presentation, RCA pFAI values are lower than those validated in atherosclerosis. The correlation between higher pFAI values, higher biventricular ESV and lower RVEF, may suggest a role of pFAI in predicting non-atherosclerotic CI (i.e., infective/immune-mediated “endothelialitis”).
Food Tray Sealing Fault Detection in Multi-Spectral Images Using Data Fusion and Deep Learning Techniques
Authors: Benouis Mohamed , Medus Leandro D. , Saban Mohamed , Ghemougui Abdessattar , Rosado-Muñoz Alfredo
Published: September 2021

A correct food tray sealing is required to preserve food properties and safety for consumers. Traditional food packaging inspections are made by human operators to detect seal defects. Recent advances in the field of food inspection have been related to the use of hyperspectral imaging technology and automated vision-based inspection systems. A deep learning-based approach for food tray sealing fault detection using hyperspectral images is described. Several pixel-based image fusion methods are proposed to obtain 2D images from the 3D hyperspectral image datacube, which feeds the deep learning (DL) algorithms. Instead of considering all spectral bands in region of interest around a contaminated or faulty seal area, only relevant bands are selected using data fusion. These techniques greatly improve the computation time while maintaining a high classification ratio, showing that the fused image contains enough information for checking a food tray sealing state (faulty or normal), avoiding feeding a large image datacube to the DL algorithms. Additionally, the proposed DL algorithms do not require any prior handcraft approach, i.e., no manual tuning of the parameters in the algorithms are required since the training process adjusts the algorithm. The experimental results, validated using an industrial dataset for food trays, along with different deep learning methods, demonstrate the effectiveness of the proposed approach. In the studied dataset, an accuracy of 88.7%, 88.3%, 89.3%, and 90.1% was achieved for Deep Belief Network (DBN), Extreme Learning Machine (ELM), Stacked Auto Encoder (SAE), and Convolutional Neural Network (CNN), respectively.
Detecting Salient Image Objects Using Color Histogram Clustering for Region Granularity
Authors: Joseph Seena , Olugbara Oludayo O.
Published: September 2021

Salient object detection represents a novel preprocessing stage of many practical image applications in the discipline of computer vision. Saliency detection is generally a complex process to copycat the human vision system in the processing of color images. It is a convoluted process because of the existence of countless properties inherent in color images that can hamper performance. Due to diversified color image properties, a method that is appropriate for one category of images may not necessarily be suitable for others. The selection of image abstraction is a decisive preprocessing step in saliency computation and region-based image abstraction has become popular because of its computational efficiency and robustness. However, the performances of the existing region-based salient object detection methods are extremely hooked on the selection of an optimal region granularity. The incorrect selection of region granularity is potentially prone to under- or over-segmentation of color images, which can lead to a non-uniform highlighting of salient objects. In this study, the method of color histogram clustering was utilized to automatically determine suitable homogenous regions in an image. Region saliency score was computed as a function of color contrast, contrast ratio, spatial feature, and center prior. Morphological operations were ultimately performed to eliminate the undesirable artifacts that may be present at the saliency detection stage. Thus, we have introduced a novel, simple, robust, and computationally efficient color histogram clustering method that agglutinates color contrast, contrast ratio, spatial feature, and center prior for detecting salient objects in color images. Experimental validation with different categories of images selected from eight benchmarked corpora has indicated that the proposed method outperforms 30 bottom-up non-deep learning and seven top-down deep learning salient object detection methods based on the standard performance metrics.
Cyclic Behavior of Calcareous Sand from the South China Sea
Authors: Liu Lu , Yao Xiaofei , Ji Zhanpeng , Gao Hongmei , Wang Zhihua , Shen Zhifu
Published: September 2021

This study examines the cyclic behavior of calcareous sand obtained from the South China Sea. A series of undrained cyclic triaxial tests were performed on the calcareous sand with various relative densities, cyclic stress ratios, and effective confining pressures. The test results show that whereas the effective confining pressure exhibited a small influence on the cyclic behavior of the calcareous sand, the effect of changes in CSR and relative density was notable. Due to its angular nature, the liquefaction resistance of calcareous sand was much higher than that of silica sand. In addition, differences between calcareous and silica sands in terms of pore pressure generation characteristics and deformation responses were also observed.
Performance and Feasibility Study of a Novel Automated Catch-Hauling Device Using a Flexible Hose Net Structure in Set-Net
Authors: Li Qiao , Li Yue , Dong Shuchuang , Mizukami Yoichi , Han Jialin , Yoshida Takero , Kitazawa Daisuke
Published: September 2021

The labor-intensive catch-hauling method in set-net fisheries faces problems of lower productivity, lower efficiency, and higher operational risk due to aging problem and labor insufficiency. To solve such problems, a novel catch-hauling device using the flexible fire hose and net (hose net), which is placed in the box chamber, was proposed in this study. The hoses were inflated with air injected into one edge of the hose net, and the buoyancy force increased: the net gradually floated up, cornering the fish in the opposite edge. To corner and harvest the fish efficiently and safely, the changing formation and motion parameters of the hose net are significant. A series of floating up, sinking experiments, and catch-hauling tests were conducted to evaluate the performance of this device. The results showed that the hose net could gradually float in an ideal form and sink smoothly through natural exhaust and stretched on the bottom of the water tank. The time spent and average speeds in floating and sinking processes varied with air pressure and airflow rate, allowing the hose net motion to be controlled in practice by adjusting the airflow. Through the catch-hauling test using live fish, most of the fish were directed into the fish bag. Two main capture failure phenomena were also observed. Overall, this newly developed automated catch-hauling device is expected to be successful for use in modern fisheries.
Ecological consolidation of lands and federal districts in Russia
Authors: Mazurkin P.M.
Published: September 2021

It is proposed to identify the hierarchy of federal districts in terms of ecological opportunities for consolidation of vegetation cover by three classes of soil cover according to the UN classification (grass + shrub + trees) on the territory of Russia by ranking the shares of vegetation cover and human-modified lands, as well as ecological coefficients. The total ecological coefficient is calculated by dividing the share of vegetation by the total share of anthropogenic land. The forest-agricultural coefficient is convenient as the ratio of the forest area to the arable land area. The article contains the identification method revealing stable regularities of rank distributions in the form of trends and wave equations.