bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic response of the high‐rise steel tridimensional parking structure for vertical impact excitation of the lifting system
Authors: He Yongjun , Zhou Xuhong , Liu Xiaohua
Published: February 2015

For the vertical lifting high‐rise steel tridimensional parking structure, the vertical impact excitation resulting from the repeated acceleration and deceleration of the lifting system is analyzed and obtained according to the operational mode of lifting system. The dynamic model of the parking structure is established, and the structural dynamic response for vertical impact excitation of the lifting system is analyzed by the finite element software ANSYS (Ansys Inc., Cecil Township, Pa, USA). Influence of various factors, such as the lifting height of the lifting cage, structural damping, parking case, speedup mode and abnormal operation of the lifting system, on the structural dynamic response is investigated, and the corresponding suggestions on vibration reduction and rational speedup mode are given. Finally, the structural dynamic buckling caused by vertical impact excitation of the lifting system is discussed. The results indicate that the maximum structural vibration response occurs in the acceleration stage after start of the lifting system and depends on the velocity pattern. Additionally, the lifting height and structural damping have not remarkable influence on the maximum structural vibration response. It is suggested that the vehicles be parked in the garage from bottom to top symmetrically, and the abnormal speedup or stop of the lifting system should be avoided. Copyright © 2015 John Wiley & Sons, Ltd.
A general solution for performance evaluation of a tall building with multiple damped and undamped outriggers
Authors: Fang C. J. , Tan P. , Chang C. M. , Zhou F. L.
Published: February 2015

This paper presents a general solution for performance evaluation of a tall building with multiple damped and undamped outriggers. First, general rotational stiffness (GRS) is proposed to model an outrigger that consists of the stiffness of perimeter columns and an outrigger connection and the damping of dampers in an outrigger. By utilizing the dynamic stiffness method, the GRS can be represented by complex stiffness in an outrigger element. To analyze the dynamic characteristics of a tall building with multiple outriggers, a dynamic transcendental equation is obtained from the combination of the GRS and dynamic stiffness method. The structural responses can be calculated through the Fourier transform based on this equation. Moreover, the GRS can also be blended into a finite element (FE) model to generate an augmented state‐space equation for the analysis of the dynamic characteristics and structural responses. Applications to various outriggers are illustrated. In the numerical analysis, good agreements are found between the GRS and the FE that validates the proposed method, and the performances of various outrigger systems are evaluated parametrically. As the results of a tall building with multiple damped or undamped outriggers, the proposed method is capable of providing an optimally parametric design with respect to the position of outriggers, damping, and core‐to‐column and core‐to‐outrigger stiffness ratio. Copyright © 2015 John Wiley & Sons, Ltd.
Analytical investigation of hybrid composite precast beams with modified strain compatibility for entire history of nominal flexural capacity
Authors: Hong Won‐Kee , Lee Yongjei , Kim Sunkuk , Kim Seung‐il , Yun Yeo‐jin
Published: February 2015

The strain compatibility documented in Chapter I of the American Institute of Steel Construction 360‐10 (AISC, 2010) was modified to provide accurate analytical solution for hybrid composite precast beams. In the proposed method, locations of neutral axis of the section are investigated to formulate all possible equilibrium equations of stress fields of composite sections. The only neutral axis satisfying all stress fields is then found for composite sections for entire loading history including yield and maximum load limit state and between those limit states. Finally, the nominal moment capacity of hybrid composite precast beam is calculated based on the correct neutral axis. Experimental study was conducted to verify the accuracy of the proposed method. The test results for hybrid composite precast beams agreed very well with the analysis results. The capacity difference between them is less than 4.8%. This study also compares the proposed design method with the conventional strength addition method, showing that the conventional method underestimated structures leading to over‐design. It was found that the new approach predicted the behaviors of hybrid composite precast beams more accurately than the conventional methods. Copyright © 2015 John Wiley & Sons, Ltd.
A multi‐version CIM‐based database platform for smart grid
Authors: Wang Lan , Murayama Hiroshi
Published: February 2015

In the smart grid area, the Common Information Model (CIM) for energy management systems is widely used. CIM is developed in a Unified Modeling Language (UML) and its entire content is maintained with one version by the IEC TC57 committee. There are officially four versions of CIM so far. For each CIM entity modeled in UML, such as a class or an attribute, there is no version information by default. This makes it extremely difficult to precisely identify a CIM entity in an application. Consequently, any application utilizing CIM faces an obstacle in maintenance and in exchange of data with other parties that may be utilizing different versions of CIM. Furthermore, CIM in UML format is unsuitable for managing a large number of instances. In order to improve the above‐mentioned compatibility and usability problem of CIM, in this paper we introduce a new International Standard, IEC 62656‐3. Through this standard, CIM can be decomposed into a set of tabular data each of which has an explicit version and can be described with a spreadsheet. This format is called Parcellized‐CIM. Based on Parcellized‐CIM, a commercial database platform, Parcimoser, is developed and applied in the engineering of smart grids. © 2015 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
The Mercury‐richest Europium Amalgam Eu10Hg55
Authors: Tambornino Frank , Hoch Constantin
Published: February 2015

The mercury‐richest europium amalgam Eu10Hg55 was synthesized by isothermal electrocrystallization from a solution of EuI3·8DMF in DMF on a reactive mercury cathode. The crystal structure shows remarkable complexity and polar metal–metal bonding. Closely related to the structures of mercury‐rich amalgams A11–xHg55+x (A = Na, Ca, Sr), it shows underoccupied Hg positions along [00z]. Eu10Hg55 can be described as hettotype structure of the Gd14Ag51 structure type.
Exploring the range of retention issues for seafarers in global shipping: opportunities for further research
Authors: Caesar Livingstone Divine , Cahoon Stephen , Fei Jiangang
Published: February 2015

Discussions surrounding the global shortage of seafarers (especially ship officers) continue to evolve and have attracted the attention of a growing number of researchers and industry practitioners in recent times. There is a general consensus within the literature that ship-to-shore mobility among seafarers (including officers and unlicensed mariners) is increasing. Prolonging the number of years that seafarers spend at sea and their subsequent retention is therefore an important issue that requires further attention. This conceptual paper (which is the product of a systematic literature review on seafarers) argues that to effectively retain ship officers and cadets at sea, the range of factors negatively influencing their retention must be identified and sufficiently managed by shipping industry employers. The result from the synthesis of the reviewed literature shows that the range of retention issues that shipping industry employers need to focus on relates mostly to the following: satisfaction with job and employer, opportunities for career progression and good working conditions. The paper also examines the cluster of human resource practices and theories among industry employers and how they eventually predict the mobility of seafarers to landside jobs. Recommendations are given on how shipping industry employers may be able to alleviate the current labour crisis within the shipping industry through prudent retention strategies.
IL28B polymorphism and early anemia predict the rapid null response in genotype‐1 chronic hepatitis C with dual therapy
Authors: Teng Wei , Chang Tzu‐Ching , Huang Chien‐Hao , Jeng Wen‐Juei , Chen Wei‐Ting , Huang Chang‐Wen , Ho Yu‐Pin , Lin Chun‐Yen , Sheen I‐Shyan
Published: February 2015

Background and aims

Rapid null response (rNR), defined as less than one log decline of Hepatitis C virus (HCV‐RNA) at Week 4 of treatment with pegylated interferon‐α and ribavirin (PegIFN/RBV), is highly correlated with treatment failure in patients with chronic hepatitis C (CHC), genotype‐1 (GT‐1). In this study, we investigate the possible predictors of rNR.

Methods

We retrospectively analyzed a cohort of 199 GT‐1 CHC naive patients who had been treated with a dual therapy of PegIFN/RBV. Clinical parameters and genotypes of rs12979860, the single nucleotide polymorphisms (SNPs) of interleukin‐28B (IL28B) were analyzed for their relationship with rNR.

Results

Of the patients analyzed, 41.7% did not exhibit a rapid virological response (RVR). Only 13.1% of patients who experienced a rNR showed an RVR. The treatment failure rate was 36.2%. High baseline viral load (OR: 5.74; p = 0.028), nonrapid virological response (non‐RVR; OR: 4.32; p = 0.004) and rNR (OR: 51.82; p < 0.001) were the predictors of treatment failure. In addition, both the non‐CC allele of rs12979860 (OR: 13.8; p < 0.001) and the Hb (hemoglobin) decline to < 3 g/dL within 4 weeks of treatment (no early anemia; OR: 4.6; p = 0.024) were predictors of rNR.

Conclusions

rNR predicted treatment failure early in GT‐1 CHC patients treated with PegIFN/RBV. Non‐CC genotype of rs12979860 and no early anemia were significant predictors of rNR.
Web Resources for Stem Cell Research
Authors: Wei Ting , Peng Xing , Ye Lili , Wang Jiajia , Song Fuhai , Bai Zhouxian , Han Guangchun , Ji Fengmin , Lei Hongxing
Published: February 2015

In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facilitate more efficient use of these resources, we have provided a preliminary rating based on our own user experience of the overall quality for each resource. We plan to update the information on an annual basis.
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours – A prognostic test after surgical resection
Authors: Kolberg Matthias , Høland Maren , Lind Guro E. , Ågesen Trude H. , Skotheim Rolf I. , Sundby Hall Kirsten , Mandahl Nils , Smeland Sigbjørn , Mertens Fredrik , Davidson Ben , Lothe Ragnhild A.
Published: February 2015

No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer.

From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis type 1, 30 MPNSTs were investigated by genome‐wide RNA expression profiling and 63 MPNSTs by immunohistochemical (IHC) analysis, and selected genes were submitted to analyses of disease‐specific survival.

The potential drug target genes survivin (BIRC5), thymidine kinase 1 (TK1), and topoisomerase 2‐alpha (TOP2A), all encoded on chromosome arm 17q, were up‐regulated in MPNST as compared to benign neurofibromas. Each of them was found to be independent prognostic markers on the gene expression level, as well as on the protein level. A prognostic profile was identified by combining the nuclear expression scores of the three proteins. For patients with completely resected tumours only 15% in the high risk group were alive after two years, as compared to 78% in the low risk group.

In conclusion, we found a novel protein expression profile which identifies MPNST patients with inferior prognosis even after assumed curative surgery. The tested proteins are drug targets; therefore the expression profile may provide predictive information guiding the design of future clinical trials. Importantly, as the effect is seen on the protein level using IHC, the biomarker panel can be readily implemented in routine clinical testing.
From pit to electronic trading: Impact on price volatility of U.S. Treasury futures
Authors: Orlowski Lucjan T.
Published: February 2015

This paper investigates the dynamics of price volatility and trading volume of 10‐year U.S. Treasury note futures within the context of transition from pit to electronic trading. The analysis is conducted over four discernible phases of futures trading evolution: the pit‐only phase, the leap to electronic trading, and the electronic trading dominant phase, which is divided further into two periods, the before and after the financial crisis of 2007/2009. Generalized autoregressive conditional heteroskedasticity with in‐mean conditional variance and generalized error distribution parameterization (GARCH‐M‐GED) tests are conducted to examine the conditional volatility of total returns index as a function of trading volume. The empirical results show a consistently negative relationship between the trading volume and price volatility for all four analyzed phases. They also show decreasing leptokurtosis (except for the direct effects of the recent crisis), continuously high persistency in volatility, as well as a weakening impact of unexpected ARCH‐type shocks during the most recent analyzed period. Overall, the shift to electronic trading entails a substantial increase in trading volume, but not in price volatility of Treasury futures.
New aristonectine elasmosaurid plesiosaur specimens from the Early Maastrichtian of Angola and comments on paedomorphism in plesiosaurs
Authors: Araújo R. , Polcyn M.J. , Lindgren J. , Jacobs L.L. , Schulp A.S. , Mateus O. , Gonçalves A. Olímpio , Morais M.-L.
Published: February 2015

New elasmosaurid plesiosaur specimens are described from the Early Maastrichtian of Angola. Phylogenetic analyses reconstruct the Angolan taxon as an aristonectine elasmosaurid and the sister taxon of an unnamed form of similar age from New Zealand. Comparisons also indicate a close relationship with an unnamed form previously described from Patagonia. All of these specimens exhibit an ostensibly osteologically immature external morphology, but histological analysis of the Angolan material suggests an adult with paedomorphic traits. By extension, the similarity of the Angolan, New Zealand and Patagonian material indicates that these specimens represent a widespread paedomorphic yet unnamed taxon.
Dust ion acoustic rogue waves in superthermal warm ion plasma
Authors: Shalini  , Saini N. S.
Published: February 2015

The properties of dust ion acoustic rogue waves (DIARWs) in an unmagnetized collisionless plasma system composed of charged dust grains, superthermal electrons and warm ions as a fluid are studied. The multiple scale perturbation method is used to derive a nonlinear Schrödinger equation (NLSE) for DIARWs. From the coefficients of nonlinearity and dispersion, we have determined the critical wave number threshold kcr at which modulational instability sets in. This critical wave number depends on the various plasma parameters, viz. superthermality of electrons, ion temperature and dust concentration. Within the modulational instability region, a random perturbation of amplitude grows and thus, creates DIARWs. It is found that DIARWs are significantly affected by electron superthermality (via κ), ion temperature (via σ) and dust concentration (via f). In view of the crucial importance of DIARWs in space environments, our results may be useful in understanding the basic features of DIARWs that may occur in space plasmas.
Peripheral eyes: Brazilians and India, 1947–61
Authors: Chakravarti Ananya
Published: February 2015

The post-Second World War era witnessed the need for new political forms to accommodate the aspirations for national identity of newly decolonized nations within the hegemonic structure of the Cold War. Although both Cold War historiography and postcolonial studies have analysed these phenomena, the place of Latin America in general and Brazil in particular remains fraught with conceptual difficulties, largely due to the very different (post)colonial experience of this region from the rest of the ‘Third World’. This article examines how three Brazilian intellectuals and diplomats observed India from its independence until the annexation of Portuguese India by the Indian Union in 1961. In exploring their peripheral gaze, it shows how Brazilian self-identification with the West, and particularly its complex relationship with the heritage of European colonialism, prevented a truly commensurable experience, despite a sense of commonality with India based on their peripheral position in the global political structure.
Potassium fertilization: paradox or K management dilemma?
Authors: Bar-Yosef B. , Magen H. , Johnston A.E. , Kirkby E.A.
Published: February 2015

In 2014, Khan et al. presented evidence that soil exchangeable K (Exch-K) increases over time without addition of potassium (K) to the soil despite the removal of K in crops on a soil rich in montmorillonite and illite. The authors term this behavior ‘The potassium paradox’. From their review of the literature, the authors also report a lack of crop response to potassium chloride (KCl) fertilization. Close evaluation of these findings reveals that their observations can be interpreted and predicted using current knowledge of K in soil chemistry and its uptake by plants, and there is no paradox in K behavior in the soil–plant system. There is also no evidence of a detrimental effect of KCl on crop yield or quality. Their conclusion that the widely used Exch-K soil test is inadequate for managing K fertilization is discussed and some possible modifications to improve its performance are included. We believe that measurement of Exch-K is an essential and valuable tool and its use should be continued, along with improvements in recommending K fertilizer application.
Further insights into why potassium fertility is a paradox
Authors: Khan S.A. , Mulvaney R.L. , Ellsworth T.R.
Published: February 2015

For many years, crop potassium (K) availability has been estimated by soil testing the plow layer for exchangeable K, in conjunction with potassium chloride fertilization widely promoted as an essential prerequisite for ensuring crop yield and quality. As rigorously documented in our paper, both components of chemical-based K management are seriously flawed by the lack of a scientific basis. Under the pretext of providing economic benefit for the producer and a healthy food supply for the public at large, the real purpose is to generate revenue for the fertilizer industry.
Prediction uncertainties in the Cape Cod reserving method
Authors: Saluz Annina
Published: February 2015

The Cape Cod (CC) method was designed by Bühlmann and Straub in order to overcome some shortcomings of the chain ladder (CL) method. Owing to its simplicity and because of the advantages over the CL method, the CC method has become a well-established method in practice. In this paper we consider a distribution-free stochastic model for the CC method. Within this model we give the parameter estimates and we derive estimates for the conditional mean square error of prediction for the CC method. In addition, we derive an estimate for the uncertainty in the claims development result.
Hemostasis and Fibrinolysis in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
Authors: Boluijt Jacoline , Meijers Joost CM , Rinkel Gabriel JE , Vergouwen Mervyn DI
Published: February 2015

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) has been associated with microthrombosis, which can result from activated hemostasis, inhibited fibrinolysis, or both. We systematically searched the PUBMED and EMBASE databases to identify hemostatic or fibrinolytic parameters that can be used for the prediction or diagnosis of DCI, or that inform on the pathogenesis of DCI and may serve as treatment targets. We included 24 studies that fulfilled predefined criteria and described 39 biomarkers. Only one study fulfilled predefined criteria for high quality. Since no parameter on admission was associated with DCI and in none of the included studies blood was drawn at the time of clinical deterioration, none of the studied parameters can presently be used for the prediction or diagnosis of DCI. Regarding the pathogenesis of DCI, it was shown that compared with patients without DCI those with DCI had higher levels of von Willebrand factor and platelet activating factor in plasma 5 to 9 days after aSAH, membrane tissue factor in cerebrospinal fluid 5 to 9 days after aSAH, and D-dimer in plasma 11 to 14 days after aSAH. Confirmation in high-quality studies is needed to investigate whether these parameters can serve as targets for new intervention studies.
Normobaric Oxygen Worsens Outcome after a Moderate Traumatic Brain Injury
Authors: Watts Lora Talley , Long Justin Alexander , Manga Venkata Hemanth , Huang Shiliang , Shen Qiang , Duong Timothy Q
Published: February 2015

Traumatic brain injury (TBI) is a multifaceted injury and a leading cause of death in children, young adults, and increasingly in Veterans. However, there are no neuroprotective agents clinically available to counteract damage or promote repair after brain trauma. This study investigated the neuroprotective effects of normobaric oxygen (NBO) after a controlled cortical impact in rats. The central hypothesis was that NBO treatment would reduce lesion volume and functional deficits compared with air-treated animals after TBI by increasing brain oxygenation thereby minimizing ischemic injury. In a randomized double-blinded design, animals received either NBO ( n = 8) or normal air ( n = 8) after TBI. Magnetic resonance imaging (MRI) was performed 0 to 3 hours, and 1, 2, 7, and 14 days after an impact to the primary forelimb somatosensory cortex. Behavioral assessments were performed before injury induction and before MRI scans on days 2, 7, and 14. Nissl staining was performed on day 14 to corroborate the lesion volume detected from MRI. Contrary to our hypothesis, we found that NBO treatment increased lesion volume in a rat model of moderate TBI and had no positive effect on behavioral measures. Our results do not promote the acute use of NBO in patients with moderate TBI.
Reduced Microvascular Volume and Hemispherically Deficient Vasoreactivity to Hypercapnia in Acute Ischemia: MRI Study Using Permanent Middle Cerebral Artery Occlusion Rat Model
Authors: Suh JY , Shim Woo H , Cho Gyunggoo , Fan Xiang , Kwon Seon J , Kim Jeong K , Dai George , Wang Xiaoying , Kim Young R
Published: February 2015

Vasoreactivity to hypercapnia has been used for assessing cerebrovascular tone and control altered by ischemic stroke. Despite the high prognostic potential, traits of hypercapnia-induced hemodynamic changes have not been fully characterized in relation with baseline vascular states and brain tissue damage. To monitor cerebrovascular responses, T2- and T2∗-weighted magnetic resonance imaging (MRI) images were acquired alternatively using spin- and gradient-echo echo plannar imaging (GESE EPI) sequence with 5% CO2 gas inhalation in normal ( n = 5) and acute stroke rats ( n = 10). Dynamic relative changes in cerebrovascular volume (CBV), microvascular volume (MVV), and vascular size index (VSI) were assessed from regions of interest (ROIs) delineated by the percent decrease of apparent diffusion coefficient (ADC). The baseline CBV was not affected by middle cerebral artery occlusion (MCAO) whereas the baseline MVV in ischemic areas was significantly lower than that in the rest of the brain and correlated with ADC. Vasoreactivity to hypercapnic challenge was considerably attenuated in the entire ipsilesional hemisphere including normal ADC regions, in which unsolicited, spreading depression-associated increases of CBV and MVV were observed. The lesion-dependent inhomogeneity in baseline MVV indicates the effective perfusion reserve for accurately delineating the true ischemic damage while the cascade of neuronal depolarization is probably responsible for the hemispherically lateralized changes in overall neurovascular physiology.
A Mouse Model of Small-Vessel Disease that Produces Brain-Wide-Identified Microocclusions and Regionally Selective Neuronal Injury
Authors: Silasi Gergely , She Jennifer , Boyd Jamie D , Xue Songchao , Murphy Timothy H
Published: February 2015

We developed a mouse model of small-vessel disease where occlusions are produced through endovascular injection of fluorescent microspheres that target ~12 μm diameter penetrating arterioles and can be localized in histology. Using Thy1-GFP transgenic mice, we visualized the impact of microocclusions on neuronal structure. Microocclusions in the hippocampus produce cell loss or neuronal atrophy (~7% of lodged microspheres led to microinfarcts), while axons within white matter tracts, as well as the striatum and thalamus became blebbed or disrupted. Although the neocortex contained more occlusions than other structures, labeled layer 5 neurons were relatively resistant to structural damage, with <2% of the lodged microspheres producing obvious neuronal damage.
Epigenetic and transcriptional determinants of the human breast
Authors: Gascard Philippe , Bilenky Misha , Sigaroudinia Mahvash , Zhao Jianxin , Li Luolan , Carles Annaick , Delaney Allen , Tam Angela , Kamoh Baljit , Cho Stephanie , Griffith Malachi , Chu Andy , Robertson Gordon , Cheung Dorothy , Li Irene , Heravi-Moussavi Alireza , Moksa Michelle , Mingay Matthew , Hussainkhel Angela , Davis Brad , Nagarajan Raman P. , Hong Chibo , Echipare Lorigail , O’Geen Henriette , Hangauer Matthew J. , Cheng Jeffrey B. , Neel Dana , Hu Donglei , McManus Michael T. , Moore Richard , Mungall Andrew , Ma Yussanne , Plettner Patrick , Ziv Elad , Wang Ting , Farnham Peggy J. , Jones Steven J.M. , Marra Marco A. , Tlsty Thea D. , Costello Joseph F. , Hirst Martin
Published: February 2015

While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known about the epigenetic changes that accompany post-natal differentiation where fully functional differentiated cell types with limited lifespans arise. Here we sought to address this gap by generating epigenomic and transcriptional profiles from primary human breast cell types isolated from disease-free human subjects. From these data we define a comprehensive human breast transcriptional network, including a set of myoepithelial- and luminal epithelial-specific intronic retention events. Intersection of epigenetic states with RNA expression from distinct breast epithelium lineages demonstrates that mCpG provides a stable record of exonic and intronic usage, whereas H3K36me3 is dynamic. We find a striking asymmetry in epigenomic reprogramming between luminal and myoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.
Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs
Authors: Amin Viren , Harris R. Alan , Onuchic Vitor , Jackson Andrew R. , Charnecki Tim , Paithankar Sameer , Lakshmi Subramanian Sai , Riehle Kevin , Coarfa Cristian , Milosavljevic Aleksandar
Published: February 2015

Tissue-specific expression of lincRNAs suggests developmental and cell-type-specific functions, yet tissue specificity was established for only a small fraction of lincRNAs. Here, by analysing 111 reference epigenomes from the NIH Roadmap Epigenomics project, we determine tissue-specific epigenetic regulation for 3,753 (69% examined) lincRNAs, with 54% active in one of the 14 cell/tissue clusters and an additional 15% in two or three clusters. A larger fraction of lincRNA TSSs is marked in a tissue-specific manner by H3K4me1 than by H3K4me3. The tissue-specific lincRNAs are strongly linked to tissue-specific pathways and undergo distinct chromatin state transitions during cellular differentiation. Polycomb-regulated lincRNAs reside in the bivalent state in embryonic stem cells and many of them undergo H3K27me3-mediated silencing at early stages of differentiation. The exquisitely tissue-specific epigenetic regulation of lincRNAs and the assignment of a majority of them to specific tissue types will inform future studies of this newly discovered class of genes.
The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue
Authors: Abramczyk Halina , Surmacki Jakub , Kopeć Monika , Olejnik Alicja Klaudia , Lubecka-Pietruszewska Katarzyna , Fabianowska-Majewska Krystyna
Published: February 2015

We discussed the potential of lipid droplets in nonmalignant and malignant human breast epithelial cell lines as a prognostic marker in breast cancer.
Applications of tunable resistive pulse sensing
Authors: Weatherall Eva , Willmott Geoff R.
Published: February 2015

This Review focusses on the recent surge in applied research using tunable resistive pulse sensing, a technique used to analyse submicron colloids in aqueous solutions on a particle-by-particle basis.
A concise route to the highly-functionalized azetidine precursor: the enantioselective synthesis of penaresidin B
Authors: Ding Feiqing , William Ronny , Kock Si Min , Leow Min Li , Liu Xue-Wei
Published: February 2015

An efficient, high-yielding and scalable synthesis of penaresidin B is achieved, in which the highly functionalized azetidine precursor is constructed and stereoselectively from glycal.
Reversal of enantioselective Friedel–Crafts C3-alkylation of pyrrole by slightly tuning the amide units of N,N′-dioxide ligands
Authors: Zhang Yulong , Yang Na , Liu Xiaohua , Guo Jing , Zhang Xiying , Lin Lili , Hu Changwei , Feng Xiaoming
Published: February 2015

Reversal enantioselective Friedel-Crafts alkylation of pyrrole with ligands derived from the same type of chiral source of L-ramipril, by slightly tuning the amide units has been realized.
The intermolecular NOE is strongly influenced by dynamics
Authors: Braun Daniel , Steinhauser Othmar
Published: February 2015

New fundamental insights in NOE theory concerning the significance of dynamics and range are presented, using coarse-grained MD simulations.
Nanostructure enhanced ionic transport in fullerene reinforced solid polymer electrolytes
Authors: Sun Che-Nan , Zawodzinski Thomas A. , Tenhaeff Wyatt E. , Ren Fei , Keum Jong Kahk , Bi Sheng , Li Dawen , Ahn Suk-Kyun , Hong Kunlun , Rondinone Adam J. , Carrillo Jan-Michael Y. , Do Changwoo , Sumpter Bobby G. , Chen Jihua
Published: February 2015

We report a 6-fold ion conductivity enhancement in PEO/LiTFSI-based solid electrolytes upon the addition of fullerene derivatives.
Tellurium: a maverick among the chalcogens
Authors: Chivers Tristram , Laitinen Risto S.
Published: February 2015

This tutorial review elucidates the fundamental concepts necessary for an understanding of the unique structures and reactivities of tellurium compounds.
Metal–organic framework based mixed matrix membranes: a solution for highly efficient CO2capture?
Authors: Seoane Beatriz , Coronas Joaquin , Gascon Ignacio , Benavides Miren Etxeberria , Karvan Oğuz , Caro Jürgen , Kapteijn Freek , Gascon Jorge
Published: February 2015

The field of metal–organic framework based mixed matrix membranes (M4s) is critically reviewed, with special emphasis on their application in CO2capture during energy generation.
Tracking the transformation and transport of arsenic sulfide pigments in paints: synchrotron-based X-ray micro-analyses
Authors: Keune Katrien , Mass Jennifer , Meirer Florian , Pottasch Carol , van Loon Annelies , Hull Alyssa , Church Jonathan , Pouyet Emeline , Cotte Marine , Mehta Apurva
Published: February 2015

Realgar and orpiment, arsenic sulfide pigments used in historic paints, degrade under the influence of light, resulting in transparent, whitish, friable and/or crumbling paints.
Tuning the structures and electron transport properties of ultrathin Cu nanowires by size and bending stress using DFT and DFTB methods
Authors: He C. , Liu G. , Zhang W. X. , Shi Z. Q. , Zhou S. L.
Published: February 2015

Electron transport properties of ultrathin Cu nanowires with diameters of 0.2–1.0 nm under different bending stresses are reported, using density functional theory and density-functional-based tight-binding approaches, for application in flexible displays and solar cells.
Hierarchical TiO2 spheres decorated with Au nanoparticles for visible light hydrogen production
Authors: Zhang Guoqiang , Zhao Zhao , Tan Huaqiao , Zhao Haifeng , Qu Dan , Zheng Min , Yu Weixing , Sun Zaicheng
Published: February 2015

Hierarchical TiO2 spheres composed of nanosheets are successfully synthesized via a simple solvothermal route.
Novel dextran/graphene oxide composite material as a sorbent for solid-phase microextraction of polar aromatic compounds
Authors: Hou Xiudan , Tang Sheng , Guo Yong , Liu Shujuan , Li Jubai , Wang Licheng , Liu Xia
Published: February 2015

A novel dextran/graphene oxide-coated SPME fiber was prepared and used for extraction of phenols and halogenated aromatic compounds.
A comprehensive spectroscopic investigation of α-(2-naphthyl)-N-methylnitrone: a computational study on photochemical nitrone–oxaziridine conversion and thermal E–Z isomerization processes
Authors: Saini Praveen , Chattopadhyay Anjan
Published: February 2015

CASSCF and 2-layer hybrid ONIOM-based computational studies on α-(2-naphthyl)-N-methylnitrone have proposed its photochemical oxaziridine formation and thermal E–Z isomerization mechanisms.
Burmese grape fruit juice can trigger the “logic gate”-like colorimetric sensing behavior of Ag nanoparticles towards toxic metal ions
Authors: Alam Md Niharul , Chatterjee Anirban , Das Sreeparna , Batuta Shaikh , Mandal Debabrata , Begum Naznin Ara
Published: February 2015

Ag NPs synthesized by Burmese grape fruit juice showed selective Hg2+sensing activity.
Melting behavior of (PdxPt1−x)n nanoclusters confined in single-walled carbon nanotubes: a molecular dynamics investigation on the effects of chirality and diameter of nanotubes, and size and composition of nanoclusters
Authors: Akbarzadeh Hamed , Shamkhali Amir Nasser
Published: February 2015

Zigzag chirality leads to greater thermodynamic stability of nanoclusters, and an fcc to hcp-like transition near the melting point is an intrinsic property.
Regio- and diastereoselectivity of the 1,3-dipolar cycloaddition of α-aryl nitrone with methacrolein. A theoretical investigation
Authors: Benchouk Wafaa , Mekelleche Sidi Mohamed
Published: February 2015

The mechanism, regio- and diastereoselectivity of the 1,3-dipolar cycloaddition of N-iso-propyl,α-(4-trifluoromethyl)-phenyl nitrone with methacrolein yielding the isoxazolidine cycloadduct has been studied at the B3LYP/6-31G(d) level of theory.
Electrospun Cr-doped Bi4Ti3O12/Bi2Ti2O7 heterostructure fibers with enhanced visible-light photocatalytic properties
Authors: Shi Hongfei , Tan Huaqiao , Zhu Wan-bin , Sun Zaicheng , Ma Yuejia , Wang Enbo
Published: February 2015

Cr-doped Bi4Ti3O12/Bi2Ti2O7 nanofibers have been synthesized by electrospinning/calcination route, which shows good visible-light activity for photodegradation of methyl orange.
Supramolecular assembly of crosslinkable monomers for degradable and fluorescent polymer nanoparticles
Authors: Yuan Conghui , Chang Ying , Mao Jie , Yu Shirong , Luo Weiang , Xu Yiting , Thayumanavan S. , Dai Lizong
Published: February 2015

Crosslinked nanoassemblies from a multiple intermolecular B–N coordination approach, are fluorescent and degradable in response to pH and d-glucose, and have the capability of self-healing.
Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends
Authors: Cassani Davide A. D. , Altomare Lina , De Nardo Luigi , Variola Fabio
Published: February 2015

Cathodic electrodeposition is a bottom up process that is emerging as a simple yet efficient strategy to engineer thin polymeric films with well-defined physicochemical properties.
A simple and sensitive high performance liquid chromatography assay with a fluorescence detector for determination of canagliflozin in human plasma
Authors: Iqbal Muzaffar , Khalil Nasr Y. , Alanazi Amer M. , Al-Rashood Khalid A.
Published: February 2015

Simple and sensitive HPLC assay for accurate quantification of canagliflozin in human plasma using telmisartan as the internal standard.
Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release
Authors: Wang Hua , Xu Ming , Xiong Menghua , Cheng Jianjun
Published: February 2015

We developed a dithiomaleimide-based nanomedicine with high drug loading, GSH-responsiveness, and FRET-indicated drug release.
Photocatalytic CO2 reduction by a mixed metal (Zr/Ti), mixed ligand metal–organic framework under visible light irradiation
Authors: Lee Yeob , Kim Sangjun , Kang Jeung Ku , Cohen Seth M.
Published: February 2015

Postsynthetic exchange (PSE) of Ti(iv) into a Zr(iv)-based MOF enabled photocatalytic CO2 reduction to HCOOH under visible light irradiation with the aid of BNAH and TEOA.
A novel Co@Au structure formed in bimetallic core@shell nanoparticles
Authors: Mayoral Alvaro , Llamosa Daniel , Huttel Yves
Published: February 2015

A new type of core–shell Co@Au nanoparticles is reported here, where the core is formed by a Co icosahedron surrounded by fcc Au facets.
Construction of kinked heteronanorods modified by metal nanoparticles with enhanced catalytic performance
Authors: Yu Pan , Zhuang Tao-Tao , Sun Meng , Wu Liang , Li Yi , Ruan Hang , Yu Shu-Hong
Published: February 2015

New kinked semiconductor–metal Au–Ag2S–ZnS and Au–Ag2S–ZnS–Au heteronanorods have been synthesized for the first time by a seed-mediated growth method and their catalytic activity has been investigated.
Diastereoselective cyclization of an aminobenzoic acid derivative and chiroptical properties of triple-stranded helical bis(phenylethynyl)benzene
Authors: Yamakado Ryohei , Matsuoka Shin-ichi , Suzuki Masato , Takeuchi Daisuke , Masu Hyuma , Azumaya Isao , Takagi Koji
Published: February 2015

Diastereoselective cyclic trimerization of 2,5-dibromo-4-hexylaminobenzoic acid followed by a Sonogashira–Hagihara coupling reaction constructed the triple-stranded helical structure of bis(phenylethynyl)benzene units.
Liquid crystalline macrocyclic azacalix[4]pyridine and its complexes with the zinc ion: conformational change from the saddle to flattened shape
Authors: Fa Shi-Xin , Chen Xiao-Fang , Yang Shuang , Wang De-Xian , Zhao Liang , Chen Er-Qiang , Wang Mei-Xiang
Published: February 2015

Regulation of phase behaviors by macrocyclic conformational variation.
Aromaticity of metallabenzenes and related compounds
Authors: Fernández Israel , Frenking Gernot , Merino Gabriel
Published: February 2015

In this review, we focus on the aromaticity of a particular family of organometallic compounds known as metallabenzenes, which are characterized by the formal replacement of a CH group in benzene by an isolobal transition metal fragment.
In search for new bonding modes of the methylenedithiolato ligand: novel tri- and tetra-metallic clusters
Authors: Anju R. S. , Saha Koushik , Mondal Bijan , Roisnel Thierry , Halet Jean-François , Ghosh Sundargopal
Published: February 2015

Photolysis ofarachno-[(Cp*Ru)2(B3H8)(CS2H)] in the presence of [Re2(CO)10] produced [(Cp*Ru)2B3H5(CH2S2){Re(CO)4}2], with a planar 8-membered ring containing heavier transition metals and a main group element.
Distal modulation of bacterial cell–cell signalling in a synthetic ecosystem using partitioned microfluidics
Authors: Luo Xiaolong , Tsao Chen-Yu , Wu Hsuan-Chen , Quan David N. , Payne Gregory F. , Rubloff Gary W. , Bentley William E.
Published: February 2015

The human gut is over a meter in length, liquid residence times span several hours.
Structural characterization of folded and extended conformations in peptides containing γ amino acids with proteinogenic side chains: crystal structures of γn, (αγ)n and γγδγ sequences
Authors: M. B. Reddy Madhusudana , Basuroy K. , Chandrappa S. , Dinesh B. , Vasantha B. , A. Venkatesha Manjunath , Balaram P.
Published: February 2015

γn amino acid residues can be incorporated into structures in γn and hybrid sequences containing folded and extended α and δ residues.
Pd(OAc)2 and (DHQD)2PHAL as a simple, efficient and recyclable/reusable catalyst system for Suzuki–Miyaura cross-coupling reactions in H2O at room temperature
Authors: Saikia Bishwajit , Ali Abdul Aziz , Boruah Preeti Rekha , Sarma Diganta , Barua Nabin Chandra
Published: February 2015

Suzuki–Miyaura cross-coupling reaction catalyzed by Pd(OAc)2–(DHQD)2PHAL is a very simple, mild, efficient and recyclable/reusable protocol for the synthesis of biaryls/heterobiaryls in neat H2O at room temperature.
DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a–N1′-linked pyrroloindoline alkaloids
Authors: Tayu Masanori , Ishizaki Takako , Higuchi Kazuhiro , Kawasaki Tomomi
Published: February 2015

The cross-coupling of tryptamine with substituted aniline to C3a–nitrogen-linked pyrroloindolines has been developedviathe consecutive cyclization of tryptamine with DMSO/Tf2O and the substitution of 3a-pyrroloindolylthionium intermediate with aniline.
Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo
Authors: Yamamoto Tsuyoshi , Yahara Aiko , Waki Reiko , Yasuhara Hidenori , Wada Fumito , Harada-Shiba Mariko , Obika Satoshi
Published: February 2015

High scalability of a novel bicyclic nucleoside building block, amido-bridged nucleic acid (AmNA), to diversify pharmacokinetic properties of therapeutic antisense oligonucleotides is described.
A new family of energetic salts based on oxy-bridged bis(dinitromethyl)furazan: syntheses, characterization and properties
Authors: Li Hui , Zhao Feng-qi , Wang Bo-zhou , Zhai Lian-jie , Lai Wei-peng , Liu Ning
Published: February 2015

Dinitromethyl-functionalized energetic salts with acceptable oxygen balance and high detonation properties were reported.
Diphenylether based derivatives as Fe(iii) chemosensors: spectrofluorimetry, electrochemical and theoretical studies
Authors: Sharma Rashmi , Chhibber Manmohan , Mittal Susheel K.
Published: February 2015

Differential pulse voltammetric studies on DPE-I and DPE-II indicating selective response to Fe3+, supported by DFT studies using Gaussian software.
One-step synthesis of surface passivated carbon microspheres for enhanced photoluminescence and their application in multifunctional magnetic-fluorescent imaging
Authors: Liu Tian , Liu Xunwei , Yao Yanjie , Zhou Juan , Zhu Jun , Sun Gang , He Dannong
Published: February 2015

A carbon@Gd-DTPA microspheres bifunctional contrast agent was prepared and applied for MR imaging and luminescent imaging. The primary Na3cit molecules have been used as an intermedium to conjugate Gd-DTPA and surface passivation agents to improve photoluminescence.
Human serum albumin-specific recognition of the natural herbal extract of Stryphnodendron polyphyllum through STD NMR, hyphenations and docking simulation studies
Authors: Tanoli Sheraz A. K. , Tanoli Nazish U. , Bondancia Tatiani M. , Usmani Saman , Ul-Haq Zaheer , Fernandes João B. , Thomasi Sérgio S. , Ferreira Antonio G.
Published: February 2015

Over the last two decades, new and more advanced strategies that help in the rapid screening and identification of new ligands for a specific macromolecule have become an important domain.
Basic polymerized imidazolide-based ionic liquid: an efficient catalyst for aqueous Knoevenagel condensation
Authors: Ding Libing , Li Hansheng , Zhang Yaping , Zhang Kun , Yuan Hong , Wu Qin , Zhao Yun , Jiao Qingze , Shi Daxin
Published: February 2015

A novel basic polymerized ionic liquid (BPIL) with intensive base sites and high surface activity was synthesized and characterized by IR,1H NMR and ESI-MS. The BPIL was used as an efficient catalyst for aqueous Knoevenagel condensations.
Process intensification for tertiary amine catalyzed glycerol carbonate production: translating microwave irradiation to a continuous-flow process
Authors: Nogueira Daniel O. , de Souza Stefânia P. , Leão Raquel A. C. , Miranda Leandro S. M. , de Souza Rodrigo O. M. A.
Published: February 2015

Different products of interest can be produced from glycerol and glycerol carbonate (GC) has received much attention in recent years because of its physical properties, nontoxicity and water solubility.
In situ growth and assembly of microporous aluminophosphate nanosheets into ordered architectures at low temperature and their enhanced catalytic performance
Authors: Gao Beibei , Tian Peng , Li Mingrun , Yang Miao , Qiao Yuyan , Wang Linying , Xu Shutao , Liu Zhongmin
Published: February 2015

A low-temperature strategy to fabricate hierarchical aluminophosphate molecular sieves without using a secondary template.
Rational design and applications of conducting polymer hydrogels as electrochemical biosensors
Authors: Li Lanlan , Shi Ye , Pan Lijia , Shi Yi , Yu Guihua
Published: February 2015

Conducting polymer hydrogels (CPHs) are conducting polymer-based materials that contain high water content and have physical properties, resembling the extracellular environment.
Facile growth of centimeter-sized single-crystal graphene on copper foil at atmospheric pressure
Authors: Li Jing , Wang Xuan-Yun , Liu Xing-Rui , Jin Zhi , Wang Dong , Wan Li-Jun
Published: February 2015

By mildly oxidizing Cu foil and slowing down the gas flow rate, centimeter-sized single-crystalline graphene was grown on Cu at atmospheric pressure.
Chemical reactions induced by oscillating external fields in weak thermal environments
Authors: Craven Galen T. , Bartsch Thomas , Hernandez Rigoberto
Published: February 2015

Chemical reaction rates must increasingly be determined in systems that evolve under the control of external stimuli. In these systems, when a reactant population is induced to cross an energy barrier through forcing from a temporally varying external field, the transition state that the reaction must pass through during the transformation from reactant to product is no longer a fixed geometric structure, but is instead time-dependent. For a periodically forced model reaction, we develop a recrossing-free dividing surface that is attached to a transition state trajectory [T. Bartsch, R. Hernandez, and T. Uzer, Phys. Rev. Lett. 95, 058301 (2005)]. We have previously shown that for single-mode sinusoidal driving, the stability of the time-varying transition state directly determines the reaction rate [G. T. Craven, T. Bartsch, and R. Hernandez, J. Chem. Phys. 141, 041106 (2014)]. Here, we extend our previous work to the case of multi-mode driving waveforms. Excellent agreement is observed between the rates predicted by stability analysis and rates obtained through numerical calculation of the reactive flux. We also show that the optimal dividing surface and the resulting reaction rate for a reactive system driven by weak thermal noise can be approximated well using the transition state geometry of the underlying deterministic system. This agreement persists as long as the thermal driving strength is less than the order of that of the periodic driving. The power of this result is its simplicity. The surprising accuracy of the time-dependent noise-free geometry for obtaining transition state theory rates in chemical reactions driven by periodic fields reveals the dynamics without requiring the cost of brute-force calculations.