bluuebunny/crossref_metadata_2025 huggingface dataset:
Edukasi Tuberkulosis pada Kader Kesehatan di Wilayah Kerja Puskesmas Mangkang, Kota Semarang
Authors: Handayani Sri , Kusuma Edi Jaya
Published: March 2024

Kader kesehatan merupakan sumber daya puskesmas yang dekat dengan masyarakat. Sebagian besar kegiatan puskesmas di lapangan selalu melibatkan kader kesehatan termasuk dalam kunjungan pasien TB dalam penyidikan epidemiologi. Namun, belum semua kader kesehatan mendapatkan edukasi mengenai TB. Sehingga dalam pengabdian ini dilakukan edukasi pada kader kesehatan tentang tuberkulosis yang meliputi gejala, pengobatan, dan stigma masyrakat terkait tuberkulosis. Pengabdian dilakukan selama 2 jam di aula kelurahan Mangkang. Dalam pengabdian ini dilakukan pengukuran pengetahuan awal pada kader, dimana didapatkan sebagian besar kader menjawab benar terkait gejala dan penyebab TB, namun masih terdapat kader yang merasa bahwa stigma tidak berdampak pada penularan TB dilapangan. Dari hasil pengabdian ini dapat disimpulkan bahwa kader kesehatan telah berhasil diedukasi terkait stigma TB dan dampaknya terhadap penularan TB di masyarakat. Miskonsepsi TB yang diidentifikasi diawal pengabdian telah berhasil diintervensi dalam proses edukasi dalam pengabdian ini.
Upaya Meningkatkan Prestasi Belajar PPKN Melalui Metode Pembelajaran Kooperatif Model Stad (Student Teams Achievement Division) Pada Siswa Kelas X IIS SMAN 1 Jelai Hulu Tahun Pelajaran 2021/2022
Authors: Sutinah Sutinah
Published: March 2024

Kegiatan belajar bersama dapat membantu memacu belajar aktif. Kegiatan belajar dan mengajar di kelas memang dapat menstimulasi belajar aktif, namun kemampuan untuk mengajar melalui kegiatan kerjasama kelompok kecil akan memungkinkan untuk menggalakkan kegiatan belajar aktif dengan cara khusus. Apa yang didiskusikan siswa dengan teman-temannya dan apa yang diajarkan siswa kepada teman-temannya memungkinkan mereka untuk memperoleh pemahaman dan penguasaan materi pelajaran. Penelitian ini berdasarkan permasalahan : (a) Bagaimanakah peningkatan prestasi belajar PKn dengan diterapkannya metode pembelajaran kooperatif model STAD ? (b) Bagaimanakah pengaruh Metode Pembelajaran kooperatif terhadap motivasi belajar PKn?. Sedangkan tujuan dari penelitian ini adalah: (a) Ingin mengetahui peningkatan prestasi belajar PKn setelah diterapkannya pembelajaran kooperatif. (b) Ingin mengetahui pengaruh motivasi belajar PKn setelah diterapkannya pembelajaran kooperatif. (c) memberikan gambaran metode pembelajaran yang tepat dalam upaya meningkatkan prestasi belajar siswa dan menjadikan siswa aktif dalam kegiatan belajar mengajar. Penelitian ini menggunakan penelitian tindakan (action research) sebanyak tiga putaran . setiap putaran terdiri dari empat tahap, yaitu : rancangan, kegiatan dan pengamatan, refleksi, dan refisi. Sasaran penelitian ini adalah siswa kelas X IIS SMAN 1 Jelai Hulu Tahun Pelajaran 2021/2022. Data yang diperoleh berupa hasil tes formatif, lembar observasi kegiatan belajar mengajar. Dari hasil analisis didapatkan bahwa prestasi belajar siswa mengalami peningkatan dari siklus I sampai siklus III, yaitu siklus I (68,42%), siklus II (81,58%), siklus III (94,74%). Simpulan dari penelitian ini adalah metode pembelajaran kooperatif dapat berpengaruh positif terhadap prestasi dan motivasi belajar siswa kelas X IIS SMAN 1 Jelai Hulu, serta model pembelajaran ini dapat digunakan sebagai salah satu alternative pembelajaran PPKn.
Eksplorasi Tumbuhan Paku (Pteridophyta) pada Tiga Daerah Topografi Berbeda di Kawasan Taman Wisata Alam Tirta Rimba Baubau
Authors: Naiym Jannatun , Munir Asmawati
Published: March 2024

Tumbuhan paku sangat menyukai tempat-tempat yang lembab, mulai dari dataran tinggi hingga dataran rendah yang memiliki curah hujan yang cukup tinggi. Hal ini dikarenakan curah hujan yang tinggi mengakibatkan kelembaban yang cukup tinggi. Penelitian ini bertujuan untuk mengetahui jenis-jenis tumbuhan paku (Pteridophyta) pada tiga daerah topografi yang terdapat di Kawasan Taman Wisata Alam Tirta Rimba Baubau. Metode yang digunakan yaitu metode eksplorasi dengan teknik purposive sampling. Data pengukuran faktor lingkungan meliputi pH tanah, suhu tanah, suhu udara, kelembaban udara intensitas cahaya dan ketinggian tempat. Teknik analisis data secara deskriptif yaitu dengan mendeskripsikan ciri-ciri morfologi setiap jenis tumbuhan paku yang ditemukan di lokasi penelitian dengan mengacu pada buku-buku identifikasi yang relevan. Hasil penelitian menyimpulkan bahwa, tumbuhan paku (Pteridophyta) yang ditemukan pada daerah topografi datar terdiri dari Bolbitis sp., Cristensenia auscifolia, Christella dentata, Christella parasitica (L.) H. Lev., Dicksonia blumei Moore, Lomaropsis kingi (Copel.) Holt, Nephrolepis bisserata (Sw.) Schott., Nephrolepis falcata (Cap.) C. Chr., Selaginella ciliaris (Retz.) Spring., Selaginella willdenowii (Desv.) Backer, Tectaria ternifolia (VA. VR) C.Chr. topografi landai terdiri dari Adiantum phylippense L., Adiantum polyphyllum Willd., Asplenium polyodon G. Forster, Asplenium tenerum. forst., Christella siamensis (Tagawa & Iwatsuki) Holt, Equistetum debile, Polystichum ductuosum, Pteris aspericaulis R. Br., Pteris ensiformis, Pteris orientalis v. Ald. v. Ros, Pteris umbrosa L. Spec., Pteris vittata L. Spec, Tectaria crenata cavanilles, dan daerah topografi bukit terdiri dari Blechnum sp., Grammitis leonardii B.S Parris, Lygodium dimorphum. Copel., Lygodium flexuosum, Lygodium longifolium (Willd) Sw., Lygodium microphyllum (cav.) R.Br.
User Satisfaction on The Efficacy of The Integrated Online Single Submission Management Information Systems
Authors: Alfian Alfian , Murti Galuh Tresna , Sarie Putri Maulida
Published: March 2024

Purpose – This research was conducted with the primary objective of examining the influence of user satisfaction on the efficacy of the Integrated Online Single Submission Management Information Systems in Indonesia

Methodology/approach – This study employs a quantitative methodology, wherein data is gathered in numerical format, and hypothesis testing is carried out through statistical analysis. A survey that included information on user satisfaction was used to collect data from 44 members the association of business actors and licensing in Indonesia. The research was conducted online using a Google Form questionnaire, which was distributed to the Association of Business Actors and Licensing in Indonesia. In this research, the chosen data analysis method is simple linear regression analysis, designed to ascertain the correlation between a dependent variable and one independent variables. The quality of the data was evaluated through validity and reliability tests, ensuring the questionnaire instrument's soundness. The statistical analysis was conducted using the IBM Statistical Package for the Social Sciences (SPSS) version 26.  

Findings –The findings suggest that the effectiveness of the integrated licensing management information system is contingent upon user satisfaction. The results underscore the system's notable efficacy in terms of user satisfaction.

Novelty/value – This study serves as a valuable tool for the assessment and enhancement of the Online Single Submission (OSS) Management Information System in Indonesia.
The Impact of Leader's Authority and Work Fulfillment on Work Performance
Authors: Syamsuddin Rahmi Andini , Fahmi Susanti
Published: March 2024

Purpose – The purpose of this study was to determine and analyze the impact of Leaders authority and work fulfillment on work performance in South Tangerang District

Methodology/approach –  The method used is descriptive quantitative with an associative approach. The population of all employees in South Tangerang District, the sample is 67 people, the technique of the sample is saturated.

Findings – It was found that. The result of this research is that Leaders authority has a significant effect on work performance with 0,994 correlation coefficient value. there is a simultaneous significant impact between Leaders authority and work fulfillment on work performance in South Tangerang District

Novelty/value –  This research focus on Work Performance that influenced by leaders authority and work performance. Based on the results of the analysis, it was found that  these  two variable have the same strong impact.
Investment Decisions On Indonesia Energy Sector Companies By Capital Asset Pricing Model Model
Authors: Edison Alva , Heikal Jerry
Published: March 2024

This research was conducted to analyze the level of investment feasibility in IDX index stocks for the 2022 period using the Capital Asset Pricing Model (CAPM) method in determining investment decisions. This type of quantitative research is descriptive. The population of this study is Oil & Gas Storage, Distribution companies listed on the IDX-IC index for the period January - December 2022. The samples are 8 company shares that meet the criteria set by the researcher. This study uses SPSS linear regression analysis to determine the beta coefficient of the Capital Asset Pricing Modeling (CAPM) method and compares the expected return with the stock market rate of return during the observation period to further distinguish between efficient and inefficient stocks. The results of the observations show that 7 companies have efficient shares and 1 company that has inefficient shares which can be seen in the SML Security Market Line (SML) graph or the securities market line (GPS) of the CAPM model for efficient shares and inefficient shares.
The Effect of Work Motivation, Work Environment, and Work Discipline On Employee Work Productivity At The H Residence Apartment East Jakarta
Authors: Permana Tian , Setiasih Setiasih , Adhani Ida
Published: March 2024

Aim - This paper tries to determine the effect of work motivation, work environment and work discipline on employees work productivity at The H Residence Apartment, East Jakarta, either partially or simultaneously.
Methodology/approach -  It uses quantitative methods and collects data through questionnaires for 56 The H Residence Apartment employees in East Jakarta.  The Slovin formula calculated the data with an error rate of (e) 5%, Classic Assumption Test, multiple linear regression analysis, the coefficient of determination (R2), t test, and F test.  
Findings  –  It was found that other variables outside the study explain 40.1%.  Then the work motivation variable (X1) has a partial effect on the work productivity variable (Y), the work environment variable (X2) has a partial effect on work productivity (Y), and work discipline (X3) has a partial effect on work productivity (Y). Partially, the most influential variable is discipline, follwed by work environment, and work motivation.
PERMASALAHAN BELAJAR DARING DI MASA PANDEMI
Authors: Balqiyah Yona , Hudaidah
Published: March 2024

Pada artikel ini membahas tentang permasalahan yang terjadi di masa pandemi ini. Penelitian ini akan membahas tentang permasalahan belajar daring, faktor pendukung dan faktor penghambat dalam pembelajan daring, serta kelebihan dan kekurangan pembelajaran daring. Penelitian ini berfokus pada siswa SD, SMP, SMA, dan Mahasiswa. Teknik pengumpulan data yang digunakan dalam penelitian ini berupa wawancara. Hasil dari penelitian ini adalah pandemi COVID-19 membawa dampak yang sangat besar terhadap proses pembelajaran, pembelajaran yang biasanya dilaksanakan secara langsung kini dialihkan menjadi pembelajaran daring.
LITERATUR REVIEW UNTUK MENGANALISIS FAKTOR E-LEARNING READINESS
Authors: AL WAAIDHOH NUZHAH
Published: March 2024

E-learning merupakan paradigma baru dalam dunia pendidikan abad ke- 21 dimana metode pembelajaran ini memperoleh respon paling kuat dalam tren pendidikan saat ini. Untuk dapat mengimplementasikan e-learning dengan baik, sebuah institusi membutuhkan perencanaan dan strategi yang baik agar mendapat hasil optimal seperti yang diharapkan. Implementasi e-learning dapat dimulai dengan mengukur e-learning readiness (tingkat kesiapan e-learning) melalui beberapa faktor. Faktor-faktor tersebut perlu dipertimbangkan secara serius guna mencegah terjadinya kegagalan saat penerapan e-learning. Penelitian ini bertujuan untuk membahas teori tentang model dan faktor e-learning readiness yang telah ditemukan oleh peneliti sebelumnya serta menganalisis faktor e-learning readiness. Penelitian ini menggunakan literature review untuk meninjau jurnal-jurnal tentang model dan faktor e-learning readiness. Hasil yang diperoleh menunjukkan bahwa Teknologi merupakan faktor paling dominan dan penting dalam e-learning readiness.
UPAYA PREVENTIF BULLYING DI KOTA SALATIGA MELALUI PENINGKATAN KECERDASAN SPIRITUAL
Authors: Tazkiyatun Nihayah Novi , Margarena Agung Novianto
Published: March 2024

Penelitian ini bertujuan untuk mencegah perundungan melalui tingkat kecerdasan spiritual. Latar belakang permasalahan pada penelitian ini yakni karena banyaknya kasus bullying yang terjadi di area sekolah. Kebaruan penelitian ini berfokus pada kecerdasan spiritual sebagai alat untuk mencegah bullying di sekolah. Penelitian ini tergolong sebagai penelitian kuantitatif non-eksperimen dengan rancangan survey. Sebanyak 50 siswa SMP Islam Sunan Giri Salatiga  dipilih secara simple random sampling dalam penelitian ini. Instrumen yang digunakan untuk pengumpulan data adalah angket kecerdasan spiritual Danah Zohar dan Marshall serta angket bullying dari Olweus Bully/Victim.   Kesimpulan hasil uji korelasi menunjukkan bahwa terjadi korelasi negatif yang signifikan antara kecerdasan spiritual dengan kenakalan remaja dengan nilai (r=-.386, n=50, p.000). Rekomendasi penelitian ini adalah sekolah mengutamakan pengembangan kecerdasan spiritual melalui pendampingan pesantren.
Enhanced Academic Stress-Coping Skills Assessment in College Students: A Comparative Study of Neutrosophic Distance Measure and Proposed Cubic Pythagorean Fuzzy Hypersoft TOPSIS Method
Authors:   Department of Mathematics, Erode Arts and Science College, Erode, Tamil Nadu, India., admin admin ,   Department of Mathematics, Erode Arts and Science College, Erode, Tamil Nadu, India.,   Department of Mathematics, IFET College of Engineering, Villupuram, Tamil Nadu, India., Krishnan M. Gopala , Bobin A.
Published: March 2024

In multi-criteria decision-making scenarios involving real numbers, interval numbers, and a combination of membership and non-membership grades, accurate decision-making is crucial yet challenging. The integration of diverse grade values into a single value poses a significant challenge for decision-makers. To address this issue, this study introduces the concept of a cubic Pythagorean fuzzy hypersoft set, facilitating information aggregation without ambiguity. The characteristics of correlation coefficients and aggregation operators are emphasized, underscoring their importance in decision-making processes. An algorithm based on correlation coefficients (CC) is proposed for the TOPSIS method, which ranks preferences based on their similarity to the ideal solution, applied here to examine how college students cope with academic stress. Furthermore, the efficiency of the proposed method is demonstrated through a comparative study, wherein the correlation coefficient in the TOPSIS method is contrasted with existing distance measures (DMs). Results indicate the superiority of CC in the TOPSIS method over DMs. In addition to comparing the proposed method with existing distance measures, the efficacy of the proposed approach is further demonstrated through a comparative analysis with established neutrosophic distance measures. This comprehensive evaluation highlights the robustness and versatility of the proposed method in addressing the complexities of multi-criteria decision-making scenarios, particularly in assessing stress management strategies among college students, thus providing valuable contributions to decision-making contexts. This study contributes to enhancing decision-making processes, particularly in evaluating stress management strategies among college students, thereby offering valuable insights for academic contexts.
Group decision-making based on distance measures settings for single-valued neutrosophic fuzzy soft expert environment
Authors:   Department of Mathematics, Faculty of Education for Pure Sciences, University Of Anbar, Ramadi, Anbar, Iraq, Faisal Faisal ,   Department of Basic Sciences, Preparatory Year, King Faisal University, Al-Ahsa 31982, Saudi Arabia; Department of mathematics and statistics, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia,   Department of Mathematics, College of Science, Qassim University, Buraydah, 51452, Saudi Arabia,   Department of Mathematics, College of Science, Qassim University, Buraydah, 51452, Saudi Arabia; Department of Operations and Management Research, Faculty of Graduate Studies for Statistical Research, Cairo University, Giza 12613, Egypt,   College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq,   Deanship of Development and Quality Assurance, King Faisal University, Al-Ahsa 31982, Saudi Arabia,   Department of Mathematics and Statistics, Institute for Management Information Systems, Suiz, Egypt, Al-Quran Ashraf Al , Alanzi Agaeb Mahal , Khalifa Hamiden Abd El- Wahed , shlaka Rawan A. , Awad Ali Mohammad A. Bany , Gomaa Heba Ghareb
Published: March 2024

A soft expert set is a concept that combines elements of soft sets and expert systems. It aims to incorporate expert knowledge and uncertainty-handling capabilities into the analysis and decision-making processes. On the other hand, the idea of single neutrosophic sets (SVNSs) and fuzzy sets (FSs) are imported models for handling the uncertainty data. In this work, the authors combine the critical features of FSs and SVNSs under expert systems in one model. Accordingly, this model worked to provide decision-makers with more flexibility in the process of interpreting uncertain information. From a scientific point of view, the process of evaluating this high-performance SVNFSES disappears. Therefore, in this paper, we initiated a new approach known as single-valued neutrosophic fuzzy soft expert sets (SVNFSESs) as a new development in a fuzzy soft computing environment. We investigate some fundamental operations on SVNFSESS along with their basic properties. Also, we investigate AND and OR operations between two SVNFSESS as well as several numerical examples to clarify the above fundamental operations. Finally, we have given distance measures (DM) between two SVNFSESs to construct a new algorithm that is used to demonstrate the effectiveness of the method in handling some real-life applications.
Unveiling the evolutionary significance: Atavisms transition from ancestral traits to a fundamental biological phenomenon
Authors: Sun Junjie
Published: March 2024

This essay delves into the nuanced concept of atavism, tracing its evolution from the abrupt manifestation of ancestral traits in wild populations to a pivotal element in contemporary biology. Explored through recent studies such as the Atavism Theory of Cancer, Single-Cell Atavism of Cnidocytes, and Atavism in the Developmental Polarity of Chicken Limb, this research reveals atavisms journey from speculative fiction to empirical reality. By scrutinizing cancer as a series of atavistic changes, experimental atavism at the single-cell level, and the atavism observed in avian limb development, the essay proposes that atavism offers fresh perspectives on evolution, adaptation, and the dynamic reuse of gene reservoirs. This study underscores atavisms transition into a tangible and crucial component of ecological and developmental biology, providing insights that traverse disciplinary boundaries and deepen our comprehension of the natural world.
Role of dopamine in regulating microglia inflammatory responses through TLR4-NFb pathway
Authors: Zhang Miao
Published: March 2024

Parkinsons disease (PD) is a prevalent neurodegenerative disorder that affects a significant portion of the population. One of its distinguishing features is the gradual loss of dopaminergic cells in a specific region of the brain known as the substantia nigra. In recent years, researchers have uncovered that neuroinflammation facilitates the developmental process of PD. Specifically, studies have shown that the activation of microglia, the brains immune cells, is closely linked to the levels of dopamine secreted by neurons. However, the influence of dopamine on activated microglia in PD has not been fully explored. In this study, we aimed to explore the impact of dopamine on activated microglia. To establish an activated microglia model, we used BV-2 cell lines and treated them with lipopolysaccharide (LPS) at a concentration of 200 ng/ml. Two separate groups were then exposed to dopamine at concentrations of 2 M and 10 M, respectively, to simulate dopamine treatment in the brain. To assess the effects of dopamine, we performed real-time PCR to measure the relative mRNA levels of pro- and anti-inflammatory cytokines, conducted immunofluorescent staining to observe and analyze the cell morphology, carried out a phagocytosis assay to assess the cells phagocytic ability, and conducted western blotting to identify the specific pathway through which dopamine affects microglia activation. Our findings revealed that dopamine can modulate the activation state of microglia and reduce the cells inflammatory responses via the TLR4-NFB pathway. This suggests that dopamine has the potential to alleviate neuroinflammation in PD, opening up new avenues for future treatments and therapies.
Gene expression controlled by stem cells and its relationship with cancer
Authors: Hu Yixiao
Published: March 2024

The stem cell is one type of cell that has a strong ability to differentiate and self-renew. It plays a vital role in the cell cycle and gene regulation. Also, due to its unique ability to self-regenerate, stem cells have the potential to produce medicines. In this article, it will talk about stem cells controlling the gene expression mechanism and focus on recent research that has revealed a relationship between stem cells and tumor cells, indicating a potential way to treat cancer, and cancer stem cell theory showing the similarity between the stem cell and the cancer cell at the starting point which gives birth to the tumor such theory gives a new understanding towards the existence of cancer. Another important subject about stem cell is mesenchymal stem cells (MSC), which is one type of stem cell that is focused and well-studied due to its owning of enormous clinical application potential.
A comprehensive review of effects of linguistic distance in bilingual aphasia
Authors: Jia Rosalyn
Published: March 2024

This literature review synthesizes three seminal studies on cross-linguistic treatment effects in bilingual aphasia. The first study delves into the interplay between language proficiency and linguistic distance in treatment outcomes, revealing nuanced findings. The second study provides new insights into the role of language characteristics and typology in bilingual aphasia, shedding light on language processing and recovery patterns. The third study offers a meta-analytic perspective, emphasizing the impact of language similarity on linguistic competence in aphasic individuals. By integrating these studies, this review aims to present a comprehensive understanding of the complex relationship between linguistic factors and treatment efficacy in bilingual aphasia.
Current research progress of whole genome sequencing in practical
Authors: Huang Zishan
Published: March 2024

Gene sequencing, a vital technique nowadays, detects patients diseases and helping with diagnosis. Whole genome sequencing (WGS) is one member of this family, which mainly functions in analysing participants gene sequences in clinical diagnosis for the purpose of indicating therapeutic interventions. This essay compares WGS and other sequencing methods, such as whole exome sequencing (WES), which comprises both positive and negative sides of this sequencing test for evaluation. And point out the help of WGS in certain diseases. This paper serves as a synopsis of some WGS-related themes as well as potential directions in the future for technical advancement.
Unlocking the diagnostic potential: N-Glycan profiling for distinguishing breast cancer patients from healthy individuals
Authors: Qian Mingyu
Published: March 2024

Chest sickness is now the most broadly perceived dangerous development, addressing 12.5% of all new yearly harmful development cases all over the planet. Around 13% (around 1 out of 8) of U.S. women will cultivate prominent chest illness all through their lives. In 2022, a normal 287,850 new occurrences of prominent chest illness should be examined in women in the U.S., close to 51,400 new examples of easy chest dangerous development. The exploration directed a review where N-glycans were gotten from the serum of bosom disease patients and solid people, and their general overflow contrasts were used for primer bosom malignant growth determination. Through Fractional Least Squares Discriminant Examination (PLS-DA), the creator had the option to successfully recognize bosom malignant growth patients from the sound populace, demonstrating the capability of N-glycan profiles in segregating between bosom disease and non-bosom disease people. This examination denotes a promising step towards the improvement of expected demonstrative and prognostic markers for bosom disease, giving likely biomarkers to beginning-phase bosom malignant growth patients. The discoveries of this study might hold critical pertinence in the field of bosom disease determination and treatment. This exploration will utilize work area and trial. Past assessment found that the level of serum N-glycan A2G1(6)FB, a biantennary N-glycan containing focus fucose and bisecting GlcNAc developments was higher in chest-threatening development patients than in those without chest illness. Additionally, A2G1(6)FB was recognizable in chest dangerous development patients with starting stage and could be a precise marker. Hence, concurrent utilization of IgG blood tests and customary biomarkers could work on the exactness of bosom disease determination, recommending that IgG blood tests might be a solid biomarker for beginning phase bosom malignant growth patients.
Mechanisms and progress in the application of traditional acupuncture methods for the treatment of lumbar disc herniation
Authors: Zheng Yuxin , Su Xiaojie , Zhao Lijuan , Zhang Guohui , Xue Xinnan , Zhang Hong
Published: March 2024

This paper summarizes the operational methods of nine acupuncture techniques recorded in the Ling Shu Guan Zhen and the mechanisms of special acupuncture techniques in the treatment of lumbar disc herniation over the past two decades. The techniques include the left and right crossing acupuncture method, local multi-needle acupuncture method, bone-piercing method, and tendon-piercing method. An overview of the types of lumbar disc herniation suitable for each acupuncture technique is provided, offering a theoretical reference for selecting appropriate acupuncture techniques in clinical treatment. However, current research lacks an exploration of the differential efficacy mechanisms among different acupuncture techniques for treating lumbar disc herniation. Issues such as the absence of standardized quantitative evaluation criteria, limited sample sizes, and a lack of long-term efficacy tracking still need improvement in future research.
Research progress on circular RNAs
Authors: Yang ZHANG , Li Qingsong , qiangman Wei
Published: March 2024

Circular RNAs (circRNAs) as a new type of non-coding RNA are special circular molecules with covalently closed 3 end and 5 end. Although they were previously discovered as errors in RNA splicing process and drew little attention, their unique properties, powerful functions and as potential disease biomarker are being increasingly acknowledged by scientists. Recently, circRNAs have become a hotspot in scientific field. In this review, we describe the biogenesis, classification, biological characteristics, functions and association with human disease of circRNAs. The emergence of circRNAs will provide a new way to study the pathogenesis of human disease, such as nervous system disease, tumor and ageing.
The role of Wnt5a in aging-related diseases
Authors: Zhang Zewei
Published: March 2024

Wnt is a family of glycoproteins that are essential signalling molecules during development, but its overexpression in adulthood leads to ageing of the organism, and in particular, the expression of Wnt5a is an important factor in the development of diseases such as atherosclerosis, osteoarthritis and tendon ageing. In atherosclerosis, patients serum levels of Wnt5a is elevated and Wnt5a is linked to -catenin-independent signaling pathways which is related to the expression of inflammatory genes and the advancement of inflammation. Osteoarthritis one character is the demolition of cartilage. In this disease, the expression model of Wnt5a will change from canonical to non-canonical, and this kind of model actives chondrocyte catabolism. Tendons can repair and regenerate themselves through tendon stem cells (TSPC). Tendon senescence is inextricably linked to the senescence of TSPC, overexpressing of Wnt5a affects tendon stem cells thus leads to tendon aging.The aim of this paper is to analyse the role of Wnt5a in the development of these diseases and suggest effective treatments for them.
A systematic review of transcranial magnetic and direct current stimulation application on the improvement of reading ability of developmental dyslexia
Authors: MU Yihong
Published: March 2024

Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), two non-invasive brain stimulation techniques (NIBS), are modulatory tools to probe into a possible causal and interaction relationship between brain structure and function. Developmental dyslexia (DD) is a neurodevelopmental disorder, which is characterized by significant and persistent difficulty in learning and reading-related skills. Previous studies have shown that TMS and tDCS play an important role in reading ability and neurocognitive plasticity, such as visuospatial working memory, attention, speech recognition, and motor perception. However, research on the effectiveness of TMS/tDCS in treating DD is still limited. The current study aimed to systematically review the broadly application of TMS/tDCS in the treatment of dyslexic children and adolescents as well as adults. Twelve studies involving 128 dyslexic subjects (199 children/adolescents and 29 adults) were included in this systematic review. Overall, TMS/tDCS appeared to be an effective technique for treating dyslexia. However, further future studies with larger sample sizes as well as more different languages are essential to demonstrate its potential for successful intervention in DD. This systematic review suggested that the combination of tDCS and cognitive training was effective. Moreover, the treatment with multiple sessions and coupled with behavioral training appeared to result in greater efficacy than stand-alone NIBS treatment.
The development and application of stem cells in biomedicine
Authors: Hua Zijun
Published: March 2024

Over the past few decades, significant advancements have been made in the field of stem cell research. Through the utilization of a literature review methodology, our study delved into an examination of three fundamental sources of stem cells, their respective activities, and the possible therapeutic applications of stem cells within the field of regenerative medicine. Furthermore, the discourse around ethical concerns pertaining to stem cell research is examined, while existing literature is consulted to identify the regulatory frameworks governing the lawful execution of embryonic stem cell research. The investigation of stem cells in the field of regenerative medicine holds significant potential for advancing human welfare. Stem cells have the capacity to replace outmoded therapy modalities, thereby offering improved alternatives. Furthermore, several diseases that were previously deemed incurable have now become viable candidates for treatment through the application of stem cell research. This research on stem cells has a dual purpose: advancing the field of regenerative medicine and deepening our understanding of life, enabling us to witness the successive wonders of existence.
Comparison and analysis of the effect of various machine learning algorithms on cancer prediction
Authors: Wang Zonghao , Wang Dan , Si Guomin
Published: March 2024

Cancer is a serious disease that can have a big impact on the physical and mental health of patients. The incidence and mortality rate of cancer are increasing globally. Therefore, predicting the occurrence and treatment effect of cancer has become a hot research topic in the medical field. Machine learning algorithms can use vast amounts of data and algorithmic models to predict aspects of cancer occurrence, progression, and treatment effectiveness. This algorithm can learn and find patterns from large amounts of medical data, thereby improving the diagnosis and treatment of cancer. In this paper, naive Bayes model, logistic regression model, random forest model, KNN model and Ridge regression model were used to predict the data of cancer patients. The accuracy of naive Bayes model and logistic regression model is the highest, reaching 95%. The accuracy of random forest model and KNN model is 94%. The worst performing model was Ridge regression, with an accuracy of 93%. Naive Bayes algorithm and logistic regression algorithm perform well in solving binary classification problems because they are both probability-based classification algorithms. In this problem, the number of features is large, so the ridge regression algorithm can effectively process the data, but due to the small amount of data, it is easy to appear underfitting, so the performance is poor. In this paper, a variety of machine learning algorithms are used to predict cancer patients, and the accuracy, accuracy, recall rate and f1 parameters of each model are calculated and compared, which provides a basis for subsequent research.
Current therapeutic targets and promising strategies for triple-negative breast cancer
Authors: Tao Sha
Published: March 2024

TNBC refers to breast cancer patients with negative estrogen receptor ER, PR and HER-2. It accounts for about 1520% of all breast cancer cases and has a higher rate of disease recurrence and a worse prognosis than other breast cancer subtypes. Chemotherapy is the most effective treatment now available for TNBC, but it has major adverse consequences on human health. Therefore, the development of new TNBC treatment strategies has become an urgent clinical need. This article first starts with the different subtypes of TNBC, analyzes and summarizes the pathogenesis of TNBC and recent research progress. Secondly, the potential targets of TNBC and the development of targeted treatments based on these targets are analyzed. Finally, it is concluded that it is easier to achieve curative effect by using appropriate specific treatments for different subtypes of TNBC. By summarizing existing treatment regimens and their applicable TNBC subtypes, this article aims to provide new insights for follow-up treatment.
Advances in the source, preparation, and application of phytosterols
Authors: Xinyue Liu
Published: March 2024

Phytosterols, also referred to as plant sterols, represent naturally occurring compounds exclusive to the plant kingdom. This comprehensive review delves into the multifaceted realm of phytosterols, encompassing their structural characteristics and physiological functions. A keen focus is placed on elucidating their sources, with an emphasis on their abundance in unprocessed materials. The paper meticulously explores the diverse methods employed in the preparation of phytosterols, concurrently scrutinizing the detection techniques applied in their analysis. Within the medical domain, phytosterols have gained recognition for their efficacy in reducing LDL cholesterol levels, thereby proving instrumental in averting cardiovascular diseases, addressing breast cancer, and managing metabolic disorders. In the cosmetic industry, plant-based oils, enriched with polyunsaturated fatty acids, function as potent antioxidants and moisturizers, counteracting the detrimental effects of free radicals. Furthermore, in the realm of the food industry, phytosterols play a pivotal role in the construction of Nanostructured Lipid Carriers (NLCs), preserving the bioavailability of various compounds. This review article stands out for its synthesis of existing research, offering succinct summaries of each section while adeptly bridging identified research gaps. Its intrinsic value lies in its potential to serve as a crucial resource for researchers, fostering deeper investigations and streamlining research endeavors in the medical, cosmetic, and food sectors.
Prevention and control of myopia based on meridians and zang-fu organs theory for unblocking meridians and harmonizing zang-fu organs
Authors: Zhao Yi , Jiang Shichao , Chen Yuxia , Chen Zhiwei , Shen Yijing
Published: March 2024

The prevention and control of myopia has always been a global challenge, as high myopia can lead to visual field defects, distorted vision, blindness, and other serious risks. Traditional Chinese Medicine (TCM) believes that myopia is the external manifestation of the overall physical condition in the eyes, which is related to the function of the eyes and the overall body functions. Based on the meridians and zang-fu organs theory, this article explores the associations of meridians and the zang-fu organs with the eyes, as well as their influence on myopia. Obstruction of meridians and disharmony of the zang-fu organs were found to be the fundamental pathological mechanisms that lead to the inability of the eyes to see distant objects. As one of the myopia prevention and control techniques, tuina shows significant therapeutic efficacy and green safety. On the one hand, it helps transport essence and brighten the eyes by unblocking the meridians around the eyes, neck, shoulder, and back to promote the flow of qi and blood. On the other hand, it can generate essence and brighten the eyes by harmonizing cold, heat, deficiency, and excess in the zang-fu organs to tonify qi and blood. Under a combination of localized and holistic action, this ultimately promotes the generation of essence and qi, unobstructed the flow of the visual pathway, and restoration of visual function, effectively preventing the occurrence and progression of myopia.
Efeitos de dietas com baixo e alto teor de proteína bruta suplementadas até o quarto aminoácido limitante para dois cruzamentos comerciais de leitões iniciantes
Authors: Souza Fábio Nicory Costa , Genova Jansller Luiz , Azevedo Liliana Bury de , Rupolo Paulo Evaristo , Santana Ana Lúcia Almeida , Melo Fúlvio Viegas Santos Teixeira de , Carvalho Silvana Teixeira , Costa Leandro Batista , Ribeiro Cláudio Vaz Di Mambro , Carvalho Paulo Levi de Oliveira
Published: March 2024

Este estudo foi composto por dois experimentos conduzidos para avaliar os efeitos de dietas com baixo e alto teor de proteína bruta suplementadas até o quarto aminoácido limitante e dois cruzamentos comerciais sobre o desempenho zootécnico, concentração de ureia plasmática (CUP), viabilidade econômica, digestibilidade aparente de nutrientes, e balanço de nitrogênio em leitões iniciantes. No Exp. I, um total de 128 leitões (14,02 ± 1,96 kg de peso corporal inicial e 48 dias de idade) foram distribuídos baseado no peso corporal inicial em um delineamento de blocos casualizados com arranjo fatorial 2 × 2. Foram avaliados dois cruzamentos comerciais (DB e PIC) e duas dietas de proteína bruta (baixa proteína bruta, BPB, e alta proteína bruta, APB). Foram utilizados quatro tratamentos, oito repetições e quatro leitões por unidade experimental. Exp. II foi conduzido utilizando 24 leitões machos inteiros (20,00 ± 1,41 kg de peso corporal inicial) alojados em gaiolas metabólicas por 12 dias e distribuídos no mesmo desenho experimental do Expt. I (seis repetições). Os resultados do Exp. I sugerem que os leitões alimentados com APB apresentaram melhor desempenho zootécnico. Foi observado um aumento de 25,2% na CUP em leitões alimentados com APB. Houve aumento de 18,2% no índice de eficiência econômica quando os leitões foram alimentados com APB, e também foi observada redução no custo por kg de ganho de peso corporal. No Exp. II, os leitões alimentados com APB apresentaram maiores coeficientes de digestibilidade aparente dos nutrientes, proteína e energia digestíveis, consumo e absorção de N. Não houve efeito dos cruzamentos comerciais sobre as variáveis de desempenho e metabolismo. Conclui-se que as dietas APB, independente da genética, promoveram melhorias no desempenho e no índice de viabilidade econômica, mas aumentaram a CUP nos leitões. Além disso, as dietas APB influenciaram positivamente a digestibilidade aparente dos nutrientes e a ingestão e absorção de N.
Workplace Violence in Orthopaedic Surgery: A Survey of Academy of Orthopaedic Surgeons Membership
Authors: Ponce Brent , Gruenberger Eric , McGwin Gerald , Samora Julie , Patt Joshua
Published: March 2024

Introduction:

Workplace violence (WPV) in US health care is increasing, and many workers are likely to experience WPV during their careers. This study aims to assess the scope of WPV in orthopaedics.

Methods:

A 20-item survey adopted from the World Health Organization's ‘Workplace Violence in the Health Sector Country Case Studies Research Instruments Survey Questionnaire’ was sent to Academy of Orthopaedic Surgeons members, including residents and fellows. Deidentified responses were collected electronically over a 1-month period and assessed.

Results:

Overall, 1,125 Academy of Orthopaedic Surgeons members participated (5% response rate). Most respondents were male (86%) and identified with the majority ethnic group (80%). WPV of any type was reported by 77.1%. Verbal abuse was the most common type (71.6%), and patients were the most common perpetrators. WPV was most prevalent among traumatologists, tumor surgeons, female surgeons, and those with 0 to 15 years in practice. Female surgeons reported more WPV events per practice year (2.25 versus 0.65, P < 0.01) and increased likelihood of physical threats and physical assaults from coworkers (P = 0.004).

Discussion:

WPV in orthopaedic surgery is largely perpetrated by patients and directed toward traumatologists, tumor surgeons, female surgeons, and less experienced surgeons. These data can be used to address safety measures in the workplace.
Magnetic Resonance Imaging in Pediatric Acetabulum Fractures with Open Triradiate Cartilage—A Report of 3 Cases
Authors: Sadhwani Shaan , Omslaer Brian , Dalton Jonathan , Sweeney Brendan , Olgun Z. Deniz
Published: March 2024

We present three cases of posterior wall acetabulum fractures occurring in pediatric patients with open triradiate cartilage for whom preoperative magnetic resonance imaging was obtained and open reduction and internal fixation was done. All patients had excellent outcomes at an average of 68-week follow-up. Failure to adequately recognize the severity of pediatric acetabulum fractures can lead to detrimental long-term sequelae in acetabular development when treated nonsurgically. Management of this rare injury is not well reported in the literature. We highlight the utility of MRI in evaluating potential nonosseous injury and examining the articular surface to guide surgical management.
Essential Factors for the Advancement of the Yarn Manufacturing Sector in Sri Lanka: Implications of the Socio-Economic Environment
Authors:   University of Kelaniya, Sri Lanka, De Silva Madushi , Withanaarachchi Amila ,   University of Kelaniya, Sri Lanka
Published: March 2024

The textile and apparel sector are well-represented in the industrial sector of the Sri Lankan economy. It has become Sri Lanka’s largest export industry since 1986. Enhancing quality and decreasing expenses are the main priorities for the Sri Lankan apparel sector, highlighting the necessity for deliberate growth. More significant export revenue and considerable import expenditure on raw materials like yarn, fabric, etc., for apparel manufacturing, is a common phenomenon in the Sri Lankan apparel sector leading to less economic value generation. Thus, this paper studies the key factors affecting the advancement of the yarn manufacturing sector in Sri Lanka and the implications of the turbulent socio-economic environment. To address the identified research problem, this study proposes a conceptual framework through a systematic literature review, which identifies the essential factors for the advancement of the yarn manufacturing sector in Sri Lanka under the current socio-economic environment. The Partial Least Square Structural Equation Modelling (PLS-SEM) method was used to capture the interactive relationships among the key factors and the advancement of the yarn manufacturing sector in Sri Lanka. Data was gathered using questionnaires from employees in the yarn manufacturing industry, textile industry, and textile engineering students in Sri Lanka. The results show that the quality of raw materials, machines and technology and better investors have a positive relationship with the advancement of the yarn manufacturing sector in Sri Lanka. Keywords: Apparel Industry, PLS-SEM and Yarn Manufacturing.
Exploring the Reactions of Bottom of The Pyramid Consumers when Protecting Consumer Rights
Authors:   University of Sri Jayewardenepura, Sri Lanka, Kavindya D.M.G.R.
Published: March 2024

Supposedly the popular belief that customers actively participate in market activity is not always the case. This is primarily due to marketers' poor consideration of consumer rights protection and a lack of awareness about the issue among both marketers and consumers. This is especially evident in developing-country markets like Sri Lanka, where certain consumer segments, such as those at the Bottom of the Pyramid (BOP), face limited consumption opportunities, making them vulnerable. As a result, the goal of this study is to investigate BOP customers' attempts to act against violations of consumer rights in an environment defined by constrained spending patterns. In-depth interviews were conducted with twenty participants from vulnerable populations in Sri Lanka's southern province. The participants were chosen using a non-probabilistic snowball sampling method, and the data was analyzed thematically. According to the study, there are two basic categories of attempts exhibited by the Bop population when acting against the violation of consumer rights. The expressive approach and the silent approach are the two approaches. Under each approach, sub-themes were identified. Although a consumer protection mechanism exists, it does not always provide adequate protection to consumers in the BOP sectors, adding to greater vulnerability and disparities in the marketplace. Keywords: BOP consumers, Consumer rights, Vulnerability