bluuebunny/crossref_metadata_2025 huggingface dataset:
UKRAINIAN HISTORIOGRAPHY ON PRE-SCHOOL, SECONDARY AND HIGHER PRIVATE EDUCATION OF UKRAINE: A COMPARATIVE ANALYSIS
Authors: KOSTIUK Polina
Published: December 2022

The study provides a systematic analysis of the historiography of private education in Ukraine. A comparison of the research level of three levels of Ukrainian private education, namely: preschool, secondary and higher is made. A systematic analysis of Ukrainian scientists' scientific works was conducted in order to highlight the specifics, common and distinctive features of private education in Ukraine. It is shown that scientific interest in the private sector of education appeared simultaneously with its formation. The analysis of scientific works devoted to preschool private education demonstrates that they treat private institutions of the first level of education not as a separate phenomenon, but mainly as a component of the state preschool system. As for scientific studies on private secondary education institutions, their analysis indicates a multifaceted consideration of them by researchers: starting from the educational process itself and borrowing foreign practices to the specifics of financing and functioning in modern conditions. As for the system of private higher education, specific examples demonstrate that researchers paid attention to the conceptual principles of the organization of education in private educational institutions, the features of their management systems, and the nature of the cognitive-educational and economic aspects of their functioning. A well-grounded approach to the study of private higher education as a social institution and a complex socio-cultural phenomenon made it possible not only to better understand the features of formation and development in the post-Soviet period but also to make predictions about the prospects for the development of private universities in Ukraine in the future.

Based on the above facts, it was concluded that domestic researchers pay uneven attention to the formation of a network of private educational institutions of different levels today. The largest number of works in the field is devoted to the sector of private higher education in independent Ukraine, both in historical development and through the prism of pedagogy, philosophy, and other fields of science. Instead, there is a lack of scientific generalizations and comprehensive works on the first and second levels of privately owned institutions.
Manajemen Pembelajaran Dalam Meningkatkan Prestasi Belajar Siswa
Authors: Sofiyah Siti
Published: December 2022

This research is based on the importance of character problems in students. In this regard, this study aims to determine the management of character education in moral student realization in SDN 1 Karanggayam. This survey is a qualitative survey. Data collection through interviews, observations and documentation. Validity of data using triangulation. Data analysis techniques include data reduction, data display, and inference drawing. This research led to his five conclusions: (1) Instill in students a sense of values ​​and morality, and aim for character education. These values ​​and morals align with the Madrasa's vision and mission. Instilled character stats include: Religious, sincere, hardworking, smart and caring. (2) The organization of character education, where teachers are role models for madrasah students, is working well. These values ​​and morals are implemented in different ways depending on each teacher's style. (3) Character education leadership includes activities that improve teacher-student relationships, provide students with opportunities to voice their opinions, and motivate students. (4) The control of character education is done by providing students with the development of moral values ​​and literacy. These skills are: Critical thinking, creative thinking, clear communication skills, listening skills, and good moral habits.
Konsep Umum tentang Kepemimpinan
Authors: Lestari Fajar Puji
Published: December 2022

Since ancient times, humans who live in groups must have known the term leadership or other designations that mean the same. Leadership is absolutely necessary when there is a cooperative interaction between two or more people in achieving goals. Leadership is concerned with someone influencing the behavior of others for a purpose. More broadly, leadership is the process of the leader creating a vision, influencing the attitudes, behavior, opinions, values, norms, and so on of its members to realize the vision. Leadership touches various aspects of human life such as how to work, neighbors, society, and even a state. Leadership, management, and administration are interconnected efforts and have a very close relationship. Leadership is the essence of management, and management is the essence of administration.
A perzisztáló hasmenés kezelése
Authors: Arató András
Published: December 2022

A dolgozat áttekinti a gyermekkori perzisztáló hasmenés epidemiológiáját, etiológiáját és diagnosztikáját, majd részletesebben tárgyalja a kezelési lehetőségeket. A terápiában legfontosabb a megfelelő rehidrálás biztosítása, de speciális kezelésre van szükség aszerint, hogy mi okozza a perzisztáló hasmenést. Mindehhez elengedhetetlen a pontos diagnosztika. A szerző felhívja a figyelmet a táplálásterápia és a megelőzés jelentőségére is.
Sustaining Cancer Care Through Collaborative Stewardship
Authors: Caldwell Ben , Blumson Eve
Published: December 2022

Cancer care has undergone rapid changes in recent years, providing dramatically improved outcomes for many patients. However, these changes have resulted in substantial increases in the costs of care in some situations. This symposium brought together a multidisciplinary faculty of experts in oncology, patient advocacy, hospital pharmacy, and health economics to discuss current issues of affordability and improving patient access to oncology medicines. The aim of the symposium was to understand what value truly means with regard to cancer care, consider what could happen when the cost of cancer care becomes unsustainable, and propose solutions to ensure optimal cancer care now and in the future.

In healthcare, it is no longer sufficient to demonstrate the effectiveness and cost-effectiveness of treatment. Now, issues of value, evidence-based decision-making, and quality must also be considered. The emerging paradigm of population and personalised healthcare was discussed by Prof Sir Gray, who highlighted the basic concepts of value-based healthcare and the need for improvement through collaborative systems and networks. The right of all patients to have equitable access to the best treatments and care was discussed by Geoffrey Henning. Among the potential solutions available, patient knowledge and empowerment will be of utmost importance, and co-ordinated campaigns by, and on behalf of, patients have the potential to change legislation for the benefit of patients.

Prof Aapro considered how cost savings from the increased use of biosimilar medicines might be re-invested to improve access to other medications, and Jatinder Harchowal provided examples of how pharmacists can improve system-wide efficiencies, thus establishing and embedding value at a fundamental level. Finally, Prof Jönsson provided an overview of the burden, cost, and cost-effectiveness of cancer management, highlighting the growing importance of appropriate economic evaluations in the new paradigm of value-based healthcare.

The session demonstrated that through the actions of patients and healthcare professionals as equal partners, a shift towards value-based healthcare and a culture of stewardship can be achieved. Importantly, these changes are necessary to safeguard the future sustainability of cancer care.
The Role of PARP Inhibitors in Ovarian Cancer: An Emerging Picture
Authors: Burchell Camille
Published: December 2022

Dr Oaknin welcomed the delegates to the symposium and presented the objectives and agenda for the meeting as well as a case study presentation. Dr Birrer presented on the current landscape of platinum-sensitive recurrent ovarian cancer (PSR OC), including USA and European treatment guidelines. He highlighted data from three landmark Phase III studies that demonstrated the efficacy of platinum-based doublet therapy for patients with PSR OC. The role of cytoreductive surgery is still being debated but bevacizumab and a newer anti-angiogenic agent, cediranib, may both extend progression-free survival (PFS) in these patients. He predicted that new combinations of therapies will be tested. Prof Ledermann followed with a presentation on the role of poly(ADP-ribose) polymerase (PARP) inhibitors, olaparib, niraparib, and rucaparib, in the treatment of PSR OC. The largest increase in PFS is seen in patients with platinum-sensitive BRCA-mutant tumours but there is also significant benefit over placebo in groups of patients with platinum-sensitive BRCA wild-type tumours. Prof McNeish discussed the challenge of identifying the 30% of women with high-grade serous OC who would respond to treatment with a PARP inhibitor even though their tumour does not carry a BRCA mutation. Loss of heterozygosity (LOH) is a key indicator of homologous recombination deficiency (HRD) but current tests miss some women who would benefit from treatment. Dr Lorusso concluded the meeting by exploring future directions for research into PARP inhibitors, such as whether they should be used in the front-line setting and as single agents rather than in combination with chemotherapy. New combinations with anti-angiogenic and immune-oncology agents show promise, as does the potential for retreatment with a different PARP inhibitor.
Possible Therapeutic Targets from Derivatives of Natural Marine Products Based on PI3K/AKT Dependent Inhibitors in Viral Infection COVID-19
Authors:   Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran, Elahe Aleebrahim-Dehkordi
Published: December 2022

Natural resources have long played a prominent part in conventional treatments as a parental source due to their multifaceted functions and lesser side effects. The diversity of marine products is a significant source of possible bioactive chemical compounds with a wide range of potential medicinal applications. Marine organisms produce natural compounds and new drugs with unique properties are produced from these compounds. A lot of bioactive compounds with medicinal properties are extracted from marine invertebrates, including Peptides, Alkaloids, Terpenoids, Steroids. Thus, it can be concluded that marine ecosystems are endowed with natural resources that have a wide range of medicinal properties, and it is important to examine the therapeutic and pharmacological capabilities of these molecules. So, finding particular inhibitors of the COVID-19 in natural compounds will be extremely important. Natural ingredients, in this light, could be a valuable resource in the progression of COVID-19 therapeutic options. Controlling the immunological response in COVID-19 patients may be possible by addressing the PI3K/Akt pathway and regulating T cell responses. T cell effector activity can be improved by preventing anti-viral exhaustion by suppressing PI3K and Akt during the early anti-viral response. The diversity of marine life is a significant supply of potentially bioactive chemical compounds with a broad range of medicinal uses. In this study, some biologically active compounds from marine organisms capable of inhibiting PI3K/AKT and the possible therapeutic targets from these compounds in viral infection COVID-19 have been addressed.
THE AMBIGUITY OF INTERTEXT: TEXTUALITY OF HISTORY IN PAVLO ZAHREBELNYI’S NOVEL “I, BOHDAN (CONFESSION IN GLORY)”. PART TWO
Authors: Nazarenko Mykhailo
Published: December 2022

In the novel “I, Bogdan” ‘historical authenticity’ is achieved through intuitive, romantic penetration of the author/narrator into the ‘nation’s spirit’ — and through the citatory narrative on the verge of cento, which the narrator emphasizes time and again. The fictional, subjective image of the hetman is presented as the only true one. The author of the novel follows two historiographical traditions, within which the fiction is not just authentic but real and true — of course, if consistent with existing narratives. These are premodern and romantic traditions. Unsurprisingly, Zahrebelnyi is happy to use the texts created both in the premodern framework (fragments of “Cossack chronicles”) and in the framework of (pre)romanticism (“History of Ruthenians”; “Zaporozhian Antiquities” by Izmail Sreznevskyi). These texts are ‘created’ and not ‘falsified’, because for their authors the reconstruction of the possible was not falsification but only filling gaps. For the author of the novel “I, Bogdan”, as well as for the romantics, the criterion of truth is compliance with the national spirit. Researchers have repeatedly noted that the novel creates the combined voice of the ‘hero-author’: it is the voice of the people themselves, on whose behalf his representative can speak.

Zahrebelnyi, when using historical sources, often turns to the palimpsest technique, rewriting or simply quoting without reference studies on Ukrainian history, especially by Mykola Kostomarov and Mykhailo Hrushevskyi, making certain ideological changes, and sometimes radically inverting the meaning of the quoted passages. Hidden intertext, therefore, may deny the explicit ideology of the text. It is obvious that the ‘encyclopedia of the model reader’ of the novel was much larger than the ‘encyclopedia’ of the empirical Soviet reader. So, in fact, the only possible ‘model reader’ was the author himself. This is a very modernist notion, and at the same time, the illusion of complete clarity on a superficial level moves Zahrebelnyi’s book closer to the poetics of postmodernism.
The Mediating Effect of Oral Health on the Relationship between the Number of Walking Days and Obstructive Sleep Apnea in Middle-Aged Koreans: Using Data from the National Health and Nutrition Examination (2019-2020)
Authors:   The Korean Society of Oral Health Science, Kim Yu-Rin
Published: December 2022

Objectives: The purpose of this study was to determine the mediating effect of oral health problems on the effects of walking exercise on risk factors for obstructive sleep apnea (OSA). Methods: This study used data from the National Health and Nutrition Examination Survey 2019-2020, and hierarchical regression was performed to confirm the mediating effect of oral health problems (chewing and speaking problems) and the effect of walking days on OSA risk factors (snoring, tiredness, witness). Results: The number of days of walking had no significant effect on OSA risk factors (β= -.011, p>.05). Oral health problem as a parameter had a significant effect on OSA risk factors [; thus] it was confirmed that there was a fully mediating effect (β=.049, p<.001). Conclusions: Based on the results, it is necessary to continuously promote the importance of walking exercise and oral health in the treatment of OSA.
Effects of Smartphone Dependence on Oral Health in Adolescents
Authors:   The Korean Society of Oral Health Science, Lim Mi-Hee , Kim Soo-Hwa
Published: December 2022

Objectives: This study investigated the relationship between smartphone dependence and health-related factors, dietary habits, and oral-related factors in adolescents. Methods: The data from the 16th Korea Youth Risk Behavior Survey (2020) was analyzed using SPSS 18.0. Results: In the smartphone overdependence group, there were significant relationships in health-related factors, dietary habits, and oral-related factors, and the higher the dependence, the more oral symptoms were. Conclusions: Strategies to reduce adolescents' dependence on smartphones and various approaches to support oral and health behaviors are needed.
A Study on the Status of Contents Related to Oral Functional Rehabilitation Exercise Based on Application
Authors:   The Korean Society of Oral Health Science, Choi Yong-Keum , Yun Ji-Hye , Park Hyang-Ah , Cha Eun-Kyung
Published: December 2022

Objectives: Based on the application status survey related to oral functional rehabilitation exercise, the need for content development in the field of dentistry is presented and basic data for development are prepared. Methods: The application was searched for keywords related to oral functional rehabilitation exercise in the Play Store and App Store, and it was classified and investigated by category, operating system, delivery method, language, cost, search term, target user, age, and exercise content. Results: As a result of searching for ‘Oral health’, ‘Tongue therapy’, ‘Oral motor’, ‘Swallowing’, ‘Dysfagi’, and ‘Oral motor exercises’ in Play Store and App Store, 10 suitable apps were found. Conclusions: The number of apps related to oral functional rehabilitation exercise is small, and there are many apps developed in other fields. Therefore, it is necessary to develop an app based on expertise in the dental medical field.
Non-Face-to-Face Learner Mutual Learning Study: Focusing on the University Liberal Arts Writing Teaching Method
Authors:   The Korean Society of Culture and Convergence, Kwak Eunhee
Published: December 2022

The purpose of this study is to propose the use of open bulletin boards to compensate for the lack of communication due to changes in the classroom environment as a necessary teaching method in the untact period. A special communication space is required because a non face-to-face learning environment negatively affects learners' achievement of learning goals compared to face-to-face classes in university writing classes. The open bulletin board is a space where teachers and learners can all share creative ideas. The entire writing process for a semester can be recorded, and peer-to-peer learning is possible by sharing data. In addition, it is effective for learner-centered teaching methods for learners to reflect on their entire writing process, and for learners to read and evaluate the writings of fellow learners as examples of various pieces of writing. The teaching method, which consists of an open bulletin board as a point of contact, is meaningful as an alternative to the lack of communication.
Analysis of Voice Characteristics of Pre-professional Voice Users Using Multidimensional Voice Evaluation: Focusing on College Students Majoring in Vocal and Acting
Authors:   The Korean Society of Culture and Convergence, Kang Kyungman , Hwang Youngjin
Published: December 2022

The purpose of this study was to examine the differences in voice characteristics between pre-professional voice users, vocal college students and acting majoring college students, using self-voice evaluation and reflux and globus sensation scale. As test tools, the Korean version of the Voice Handicap Index (K-VHI), the Korean version of the Voice-Related Quality of Life (K-VRQOL), the Reflux Symptom Index (RSI), and the Glasgow-Edenburgh Thraot Scale (GETS) were used. The subjects of the study were 68 students, including 27 college students majoring in vocal and 41 college students majoring in acting. As a result of the study, K-VHI(F), RSI, and GETS scores of college students majoring in acting were significantly higher than college students majoring in vocals (p <.05), and there was no significant difference in K-VRQOL. The students majoring in acting had more voice problems, reflux symptoms, and a globus symptoms in the throat than vocal students. These results were related to voice hygiene level and lifestyle habits. Therefore, education on the effects of lifestyle habits related to voice hygiene on voice can be helpful for prospective professional voice users.
Psychological Characteristics and Political Party Preference: Differences in Schadenfreude, Empathy, and Zhongyong
Authors:   The Korean Society of Culture and Convergence, An Doyoun
Published: December 2022

The present study investigated the psychological differences as among political party preference(i.e. the ‘People Power Party(PPP)’, the ‘Democratic Party of Korea(DPK)’, other conservative parties(OC), and other liberal parties(OL)). Three-hundred and thirty adults(women=165) completed an online survey comprising the Schadenfreude Tendency Scale, the Interpersonal Reactivity Index, the Zhongyong Questionnaire, and the preferred political parties and support level. Results showed that there was no significant difference in Shadenfreude by political party preference, but there was a significant difference in empathy and Zhongyong attitude. The individuals with DPK preference reported higher levels of empathy and Zhongyong compared to those with PPP, OC, and OL preference. In addition, it was examined whether there were differences in the three variables according to political party preference and support level. The interaction effects in all variables were insignificant. However there was a marginal interaction effect in Shadenfreude.
A Short-term Longitudinal Study on the Effects of Teacher's Feedback in Writing Classes: Focused on Online Classes for Undergraduate International Students
Authors:   The Korean Society of Culture and Convergence, Yang Jisun
Published: December 2022

This study analyzes how the correctional feedback provided by the teacher affects the error reduction and writing improvement of undergraduate international students. Many learners said they wanted to receive direct feedback, but what was more helpful for their writing was indirect feedback. Feedback about composition of the writing was regarded more important, followed by content of writing, sentence structure, grammar error, spelling and vocabulary error, and word spacing. The error patterns were different depending on the feedback time and class. The number of writing, grammar, and word spacing errors decreased in the multinational class compared to the Chinese students class. It was found out that feedback accompanied by positive evaluation helps to strengthen their writing skills.
The “Internal Working Model,” a Key Concept in Bowlby’s Attachment Theory, Research Trend Analysis in Korea
Authors:   The Korean Society of Culture and Convergence, Park Daeheum , Song Yungsook
Published: December 2022

The purpose of this paper is to analyze the current status of domestic research on the “internal working model(IWM)”of attachment formed by interactions between mother and child in the early stages of life, and to suggest directions for future research. The papers published in domestic journals from 1991 to 2021 on the topic of IWM of attachment were searched by RISS and Google scholar. And selected 35 papers among them. As a result of the analysis, by the samples of the study, the majority of research papers were 9 papers (34.6%) out of 26 papers targeting 20-year-olds and college students followed by 4 papers each targeting mothers and mother-child pairs (15%). And by subjects the study between the IWM of the primary caregiver and the IWM of mothers and children by the developmental period of their children showed the highest frequency with a total of 14 studies (40.0%). By research methods, 20 quantitative studies (57%) and 15 qualitative studies (43%), were relatively balanced. As for future research directions, the study participants are expanded to include the elderly, and the subject also suggests a study on the relationship between attachment type and death anxiety.
Tricotilomanía en una adolescente durante la pandemia del COVID-19. Reporte de un caso
Authors: Huete-Cordova María Antonieta , Herrera-Del Águila Dwight Denis , Ocampo-Zegarra Juan C.
Published: December 2022

La tricotilomanía es un trastorno que tiende a la cronicidad y consiste en jalarse y arrancarse el cabello como acto compulsivo, lo cual genera diversas zonas de alopecia. En casos extremos post ingesta crónica de cabello puede generarse severos trastornos del sistema gastrointestinal como lo son los tricobezoares. Estos son hallados en 1% de los pacientes que se comen sus cabellos. Presentamos el caso de una paciente mujer de 11 años que ingresa al Hospital Nacional Guillermo Almenara Irigoyen por una obstrucción intestinal por tricobezoar, es atendida por el servicio de cirugía. Una vez realizado el procedimiento quirúrgico es evaluada por el servicio de psiquiatría de niños y adolescentes.
Cefalea: Seguridad del Acetaminofén durante el embarazo. Revisión Sistemática
Authors: Takahashi-Ferrer Carolina Mayo
Published: December 2022

Introducción: Uno de los síntomas más recurrentes durante el embarazo es la cefalea, para aliviarlo el fármaco más recetado es el analgésico Acetaminofén (paracetamol). Objetivos: Describir la seguridad del uso de acetaminofén en caso de cefalea durante el embarazo. Material y métodos: Es una revisión sistemática de trabajos de investigación, donde se siguió la recomendación PRISMA buscando artículos científicos publicada en: Science Direct, Elsevier, Ebsco, Pubmed, Redalyc, Scielo, Google académico, Latindex, Lilacs y Alicia, durante el período 2018 al 2022. Resultados: De un inicial de 447742 estudios correspondientes a la búsqueda bibliográfica, sin aplicar filtros, se utilizó el formato PRISMA según su recomendación, quedando un total de seis artículos científicos, de los cuales cinco artículos, recomienda el uso del acetaminofén (paracetamol) en caso de dolor de cabeza en embarazadas, además afirman que es seguro su uso durante todo el embarazo, en particular Chaves E, et al., (2020) señala que de acuerdo con la clasificación de riesgo de la Administración de Alimentos y Medicamentos (FDA), el accetaminofén se clasifica como Categoría B, lo que significa que este a medicamento no se le ha descrito ningún riesgo para el feto. Conclusiones: El uso de acetaminofén durante el embarazo en caso de cefalea es seguro.
Intercambiabilidad de medicamentos en el Perú
Authors: Martínez-Vargas Alfonso Zavaleta
Published: December 2022

En el mercado farmacéutico de múltiples países se ofrecen medicamentos innovadores, medicamentos de marca, genéricos y multiplicidad de medicamentos copia (multi- fuentes), para el tratamiento de las dolencias de los enfermos,  sin embargo los usuarios no necesariamente conocen las diferencias que existen entre ellos y por ende no están en capacidad de juzgar cual medicamento le ofrece las garantías de seguridad y eficacia clínica esperadas. Los medicamentos multifuentes intercambiables y los medicamentos “similares” no son iguales necesariamente(1).
Acotaciones a la tradición renacentista del Económico III
Authors: González Manjarrés Miguel Ángel
Published: December 2022

Se estudian aquí tres cuestiones referidas a la tradición renacentista del Económico III de Pseudo Aristóteles: (1) la difusión del texto y sus versiones en los siglos XV y XVI; (2) la ‘retroversión’ al griego de Bernardino Donato, desde muy pronto atribuida a Jacques Toussain; (3) la interpretación de un pasaje del capítulo tercero en que Giovan Battista Pio, en su comentario a Lucrecio, cambia la expresión nec metum incutiat por nec cunnum quatiat. Esta lectura, suavizada como nec partes quatiant, se retomaría a comienzos del siglo XVII en la obra ginecológica de Rodrigo de Castro.
Propertius 1.1: Old and new solutions
Authors: Hardy Maxwell Andrew
Published: December 2022

An attempt is made to resolve three problems of text and interpretation in the first poem of Propertius: 3 constantis … fastus (leg. constanti … fastu), 12 ille uidere (leg. comminus ipse), 24 ducere (leg. uertere).
Sul rapporto fra ds e la tradizione manoscritta serviamo (con note sul commento a Georg. 1.1-278)
Authors: Stok Fabio , Ramires Giuseppe
Published: December 2022

Nell’articolo è esaminata l’unica parte del commento serviano alle Georgiche per la quale è disponibile DS. Il confronto fra i manoscritti serviani e l’unico testimone di DS, il codice di Leida Voss. lat. Oct. 80, suggerisce che la divisione della tradizione serviana nei rami  e  sia posteriore all’epoca della compilazione di DS. Sono proposte nell’articolo anche diverse modifiche del testo pubblicato da Thilo.
Gender Gaps in Wages and Managerial Positions: Do Family-Oriented Policies Contribute to Achieving Gender Equality among European University Graduates?
Authors: Herrarte Sánchez Ainhoa , Bellido Gómez-Salcedo Fernando
Published: December 2022

This article analyzes the gender gap in wages and access to managerial positions among university graduates in 12 European countries and explores the capability of work-family balance policies to close these gaps. Using the REFLEX database, we apply the coarsened exact matching algorithm to construct a balanced sample of women and men with the same academic characteristics (field of study, internships, and academic achievement, among others). The analysis reveals that the academic program characteristics play a relevant role in labor market outcomes as the gender gaps diminish when controlling for academic features. We find that gender differences in hourly wages and access to top wages are smaller in countries with longer paid paternity leaves and larger enrollment rates of children aged 0-3 years in preschools. In contrast, work-family reconciliation policies have little effect on the constraints women face in accessing high-level positions that require strong commitment and availability.
Perspectiva de género en el turismo deportivo de naturaleza
Authors: Rojo-Ramos Jorge , Galán Arroyo Carmen , Manzano-Redondo Fernando , González-Bercerra María José , Gómez-Paniagua Santiago , Adsuar José Carmelo
Published: December 2022

Dada la relevancia que está tomando el turismo de naturaleza como principal alternativa de ocio, siguiendo los principios de sostenibilidad, minimizando el impacto ambiental, la cultura local, y contribuyendo a la generación de ingresos y empleo; estudios anteriores han tratado de analizar la demanda considerando a los turistas como un grupo homogéneo. El desarrollo del turismo requiere incorporar el enfoque de género para conocer su impacto diferenciado en materia de sostenibilidad lo que le permitirá implementar las acciones y actividades turísticas indicadas, eficaces y efectivas. Por consiguiente, este estudio pretende analizar el perfil sociodemográfico del turista de naturaleza en España segmentándolo desde una perspectiva de género, para ofrecer una oferta ordenada que permita satisfacer la necesidad de acercarse al medio natural y contribuir a la igualdad de género. Para ello, se han analizado los datos obtenidos de la Encuesta de Turismo de Residentes del Instituto Nacional de Estadística de 2019, a partir de una muestra de 3.768 personas, seleccionando aquellos viajeros cuyo motivo de viaje principal fuera turismo de naturaleza. Los hallazgos muestran que hay un mayor porcentaje de mujeres que de hombres, en su mayoría con un perfil más joven, que viven en pareja o con cónyuges, con un mayor porcentaje sin carga familiar, con un mejor nivel académico y mayores ingresos que los hombres, que trabajan por cuenta ajena con empleos fijos. En conclusión, es importante realizar un estudio detallado desde la perspectiva de género para que el turismo de naturaleza aborde realmente los retos de la sociedad y promueva las herramientas necesarias para lograr la igualdad de género a nivel global.
Traducción y adaptación transcultural al español del Self-Evaluation of Teacher Effectiveness Questionnaire in Physical Education
Authors: Rojo-Ramos Jorge , Gómez-Paniagua Santiago , Mañanas-Iglesias Carlos , Galán-Arroyo Carmen
Published: December 2022

La labor del docente es un elemento fundamental en el proceso enseñanza-aprendizaje, influyendo incuestionablemente en la consecución de los objetivos del alumnado. Por tanto, su eficacia a la hora de llevar a cabo su trabajo es una cuestión de prioridad para evaluar su labor en las aulas. El objetivo de este trabajo es realizar una traducción y adaptación transcultural del cuestionario Self-Evaluation of Teacher Effectiveness Questionnaire in Physical Education (SETEQ-PE), cuya función es la autoevaluación por parte del profesor de su eficacia docente. Para ello, se desarrolló un proceso de traducción y retrotraducción de la escala por parte de profesionales con una amplia experiencia en el campo, de forma que se adaptó el cuestionario sin reportar ningún ítem conflictivo. Este procedimiento ha dado lugar a una versión española del SETEQ-PE muy similar en comparación a la herramienta original, lo que permitirá a los docentes hispanohablantes una autoevaluación precisa de su trabajo.
SOSIOLOGI SASTRA DAN NILAI PENDIDIKAN KARAKTER NOVEL THE KING ETERNAL MONARCH 1
Authors: Mahendra Pradika Kuthut Dwi , Hasanudin Cahyo , Mujahidin Ali
Published: December 2022

Novel is a literary work that describes the socio-cultural life and values ​​of life in society. The aims of this study are: 1.) To describe the socio-historical of the author, 2.) To describe the influence of events in the novel on society based on social aspects, 3.) To describe the reader's response to the contents of the novel, 4. ) To describe the value of character education in the novel, 5.) Describing the relevance of novels in learning literature in high school. The research method used is descriptive-qualitative with a sociology of literature approach. The results obtained in this study are: 1.) The King Eternal Monarch 1 novel was born from a writer who tends to always choose the romance genre that is packaged with fantasy, social and cultural fiction. 2.) Readers of The King Eternal Monarch 1 novel tend to like this novel because of its strong character packaging and unpredictable plot. 3.) The King Eternal Monarch 1 novel can have a good influence on society through emerging social aspects including, Religious Aspects, Political Aspects, Leadership Aspects and Economic Aspects. 4.) The King Eternal Monarch 1 novel contains character education values ​​according to the statement of the Ministry of National Education (2010) including honesty, religious, discipline, hard work and independence. 5.) The implementation of social values ​​and character education is appropriate and relevant to be used as literature teaching materials in high school.
Stor variation när elever visualiserar naturvetenskap
Authors: Westman Anna-Karin
Published: December 2022

Elever som får i uppgift att skriva, rita eller på annat sätt visualisera det naturvetenskapliga innehållet från undervisningen kan välja olika inriktningar för sin framställning. Forskaren Elin Westlund har undersökt vilka olika typer av bilder elever använder för att illustrera ett naturvetenskapligt ämnesinnehåll. I studien hittades både ett etablerat sätt att illustrera naturvetenskap men också okonventionella sätt att illustrera innehållet.
Functionalization of graphene nanostructures with inorganic nanoparticles and their use for the removal of pharmaceutical pollutants in water
Authors: Oliveras Jana , Marcon Lionel , Bastús Neus G. , Puntes Victor
Published: December 2022

Emerging pollutants such as pharmaceuticals are of special concern because despite their low environmental concentration, their biological activity can be intense, and they should be prevented to reach uncontrolledly to the environment. A graphene-based hybrid material decorated with Fe3O4 and TiO2 nanoparticles (NPs) has been prepared to effectively remove emerging pollutants as nonsteroidal anti-inflammatory drugs (NSAIDs) Ibuprofen and Diclofenac present in water at low environmental concentrations by a one-step functionalization process following a novel gentle and scalable surfactant depletion approach. Following this methodology, nanoparticles are progressively deprived of their original surfactant in the presence of graphene, leading to the formation of hybrid nanostructures composed of two different types of nanoparticles well dispersed over the graphene nanosheets. Ibuprofen and Diclofenac adsorption kinetics on the composites was investigated via UV-Vis spectroscopy. The as prepared hybrid material possesses high adsorption capacity, superparamagnetic properties, photocatalytic behavior, and good water dispersibility. Thanks to incorporating TiO2 nanoparticles as in situ catalysts, the adsorption performance of composites is restored after use, which could be a promising recycling pathway for the adsorbents in wastewater treatments.
Distinctive microbiota of delayed healing of oral mucositis after radiotherapy of nasopharyngeal carcinoma
Authors: Jiang Rui , Liu Yafang , Zhang Han , Chen Yitang , Liu Ting , Zeng Jindi , Nie Ermin , Chen Songling , Tan Jizhou
Published: December 2022

Background

Oral mucositis is the most common complication after radiotherapy of nasopharyngeal carcinoma (NPC). Previous studies had revealed that oral microbiota took great alteration soon after and during radiotherapy. Here, we aimed to investigate if the alteration of oral microbiota was related to delayed healing of oral mucositis after six month of radiotherapy.

Methods

We recruited 64 NPC patients and collected samples after six month of radiotherapy. 32 patients were included into normal healing group (N), 22 patients were mild delayed healing group (M), while 10 patients were severe delayed healing group (S). 16S rRNA gene sequencing was used to assess and identify oral microbiota alteration.

Results

The diversity of oral microbial communities was not significantly different. Composition of oral microbial was huge different among S group, for the Actinobacteria and Veillonella were significantly increased, which showed significant dysbiosis of the oral microbiome. Functional analysis of metabolic pathways of oral microbiota demonstrated that degradation of organic acids and amino acids were significantly increased in S group. Moreover, phenotype analysis found that relative abundance of aerobic and biofilm formation were higher in S group. We also found the Actinobacteria co-occurred with Veillonellaceae, but anti-occurred with other biofilm oral bacteria. These two biomarkers may be predictable for severe delayed healing of oral mucositis after radiotherapy.

Conclusion

This study suggests a potential association between oral microbiome and delayed healing of oral mucositis. The Actinobacteria and Veillonellaceae may be biomarkers in predicting the risks for the severe delayed healing of oral mucositis after radiotherapy of NPC.
Comparative genomic analysis of plasmids harboring blaOXA-48-like genes in Klebsiella pneumoniae
Authors: Li Wang , Guo Hengzhao , Gao Yi , Yang Xiaofan , Li Ruirui , Li Shuangyu , Sun Chunlong , Du Wen , Chen Shaopeng , Xu Pengpeng , Huang Wenwen , Shi Jia , Yi Xinfeng , Li Xiaobin
Published: December 2022

The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious medical problem worldwide. Acquired OXA-48-like carbapenemases encoded by plasmids are important causes of carbapenem resistance in K. pneumoniae. To explore the links between plasmids and blaOXA-48-like genes in K. pneumoniae, we systematically analyzed the variants of blaOXA-48-like plasmid replicon types, phylogenetic patterns, geographic distribution, conjugative transfer regions, and the genetic environments surrounding blaOXA-48-like of 191 blaOXA-48-like-harboring plasmids, which were identified from 4451 plasmids of K. pneumoniae downloaded from GenBank. Our results showed that seven different variants of blaOXA-48-like genes were identified from the 191 blaOXA-48-like-harboring plasmids in K. pneumoniae, with blaOXA-48, blaOXA-232, and blaOXA-181 being highly prevalent. In K. pneumoniae, blaOXA-48 was mainly carried by the composite transposon Tn1999.2 located on IncL/M-type conjugative plasmids, which were mainly geographically distributed in Switzerland, Germany, and China. In K. pneumoniae, the blaOXA-232 gene was mainly carried by 6.1-kb ColKP3-type mobilizable plasmids, which were mainly isolated in India. In K. pneumoniae, blaOXA-181 was mainly carried by a group of 50-kb ColKP3-IncX3 hybrid conjugative plasmids and a group of small ColKP3-type mobilizable plasmids with lengths of 5.9–9.3 kb, the former was sporadically discovered in China, South Korea, India, and Czech Republic, while the latter was almost all isolated in India. In addition, five blaOXA-245-harboring 65.9-kb IncL plasmids of K. pneumoniae isolated in Spain were found to have the genetic context of blaOXA-245 more complicated than that of blaOXA-48-harboring IncL/M-type plasmids, with two copies of IS1R inserted both upstream and downstream of blaOXA-245-lysR. These findings enhance our understanding of the genetic diversity of blaOXA-48-like-harboring plasmids in K. pneumoniae.
Research landscape of exosomes in platelets from 2000 to 2022: A bibliometric analysis
Authors: Zhan Min , Shi Shengnan , Zheng Xiaoyu , Chen Wenjie , Sun Linjuan , Zhang Yehao , Liu Jianxun
Published: December 2022

Background

Blood-derived exosomes are involved in developing multiple pathological processes, with platelets being the most well-known source. Related studies have become an area of research with significant value and potential. However, no bibliometric studies in this field have yet been identified. We aimed to analyze the hotspots and academic trends of platelet exosome research through bibliometric visualization to actively grasp the research base in this field and track its developmental orientation.

Methods

From 2000 to 2022, we screened all relevant publications on platelet exosome-related research from the Web of Science database, generated knowledge maps using VOSviewer and CiteSpace software, and analyzed research trends in the field.

Results

A total of 722 articles were screened for inclusion based on the search strategy. The number of articles on exosome studies in platelets has expanded vastly. The USA and the People’s Republic of China contributed substantially among 69 countries or regions. Amsterdam University and Semmelweis University are the research institutions with the most publications. The most studied and co-cited journals were the International Journal of Molecular Sciences and the Journal of Extracellular Vesicles. We identified 4,598 authors, with Nieuwland Rienk having the highest number of articles and Bruno Stefania having the most cited publications. Keywords of great interest include “thrombosis,” “anti-inflammatory,” “anti-apoptosis,” “angiogenesis,” “microparticles,” “miRNAs,” “stem cells,” and “biomarkers,” which are key research areas for future development.

Conclusion

We used bibliometric and visualization methods to identify hotspots and trends in platelet exosome research. Platelet exosome research is widely expanding. Future research will most likely focus on “thrombosis,” “anti-inflammatory,” “anti-apoptosis,” “angiogenesis,” “microparticles,” “miRNAs,” “stem cells,” and “biomarkers.”
Pleiotropic effect of sodium-glucose cotransporter 2 inhibitors on blood pressure
Authors: Kao Ting-Wei , Huang Chin-Chou
Published: December 2022

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been incorporated as guideline-directed medical therapy for heart failure with reduced ejection fraction. Recent trials clearly established the efficacy of SGLT2 inhibitors on cardiac remodeling while preventing renal function decline in patients with or without diabetes mellitus. Blood pressure reduction during SGLT2 inhibitors use has been proposed through pleiotropic pathways and as a potential contributor that translates to cardiovascular benefits. The mechanisms underlying this decrease in blood pressure are not simply glycemic control. Orchestrating fluid status, modulation of sodium content and renin-angiotensin-activation system, anti-fibrosis and anti-inflammatory effect, ameliorating the characteristics of metabolic syndrome, as well as restoration of circadian rhythm all contributed to the BP lowering effect by SGLT2 inhibitors. Although SGLT2 inhibitors has not been demonstrated as anti-hypertensive agents thus far, their effects on BP alteration are clinically significant. In this review, we revisited the evidence correlating SGLT2 inhibitor use with blood pressure level. Future research directions will focus on the signaling pathway of SGLT2 inhibitors for fluid removal, atherosclerosis, vasoconstriction, and eventually hypertension.
Time of the low-level cardiopulmonary exercise test does not affect the evaluation of acute myocardial infarction in stable status
Authors: Zhao Lanting , Liu Yuanwei , Li Siyuan , Xie Ying , Xue Yajun , Yuan Yifang , He Rong , She Fei , Lv Tingting , Zhang Ping
Published: December 2022

Introduction

Cardiopulmonary exercise test (CPET) provides the means to evaluate the cardiopulmonary function and guide cardiac rehabilitation. The performance of acute myocardial infarction (AMI) patients at different times is different on CPET.

Materials and methods

This was a cross-sectional study. Patients diagnosed as AMI in stable status were included and performed the low- level CPET (RAMP 10W). CPET variables at different times were compared among four groups.

Results

Sixty and one patients with AMI conducted the low-level CPET from 3 to 15 days after AMI. Patients were stratified according to quartiles of CPET's time: 5 in 3–6 days group, 34 in 7–9 days group, 14 in 10–12 days group, 8 in 13–15 days group. Only VO2/HR at rest showed statistically different among the four groups.VO2/HR at rest in 3–6 days group and 10–12 days group were higher than in 13–15 days group (3.4 ± 0.85, 3.18 ± 0.78 vs. 2.50 ± 0.49 ml/beat, p < 0.05). Patients with complete revascularization had higher peak heart rate and blood pressure product and peak breathing reserve (BR), and lower Borg score compared with incomplete revascularization. And patients with LVEF >50% had higher peak BR compared with LVEF 40–50%.

Conclusion

It was safe and efficient to conduct the low-level CPET in stable AMI patients 3 days after onset. Time was not an effector on cardiopulmonary function and exercise capacity and prognosis in AMI during CPET. Complete revascularization and normal LVEF should be good for exercise test in AMI.
Designing evidence-based support aids for social media access for individuals with moderate-severe traumatic brain injury: A preliminary acceptability study
Authors: Zhao Fangyun , Lim Hajin , Morrow Emily L. , Turkstra Lyn S. , Duff Melissa C. , Mutlu Bilge
Published: December 2022

Background

Adults with traumatic brain injury (TBI) report significant barriers to using current social media platforms, including cognitive overload and challenges in interpreting social cues. Rehabilitation providers may be tasked with helping to address these barriers.

Objectives

To develop technological supports to increase social media accessibility for people with TBI-related cognitive impairments and to obtain preliminary data on the perceived acceptability, ease of use, and utility of proposed technology aids.

Methods

We identified four major barriers to social media use among individuals with TBI: sensory overload, memory impairments, misreading of social cues, and a lack of confidence to actively engage on social media platforms. We describe the process of developing prototypes of support aids aimed at reducing these specific social media barriers. We created mock-ups of these prototypes and asked 46 community-dwelling adults with TBI (24 females) to rate the proposed aids in terms of their acceptability, ease of use, and utility.

Results

Across all aids, nearly one-third of respondents agreed they would use the proposed aids frequently, and the majority of respondents rated the proposed aids as easy to use. Respondents indicated that they would be more likely to use the memory and post-writing aids than the attention and social cue interpretation aids.

Conclusions

Findings provide initial support for social-media-specific technology aids to support social media access and social participation for adults with TBI. Results from this study have design implications for future development of evidence-based social media support aids. Future work should develop and deploy such aids and investigate user experience.