bluuebunny/crossref_metadata_2025 huggingface dataset:
FACTORS INFLUENCING JOB-QUIT AMONG NEWSPAPER JOURNALISTS IN PAKISTAN
Authors:   Mass Communication, University of Karachi., Ali Waqas , Irfan Muhammad ,   ass Communication, Federal Urdu University of Arts, Science & Technology, Ahmed Ayaz ,   Mass Communication, Federal Urdu University of Arts, Science & Technology.
Published: June 2023

A survey was conducted on 446 newspaper journalists working in Karachi, who do journalism in Sindhi, Urdu, and English languages, to understand the reasons for their job quitting. The findings revealed that low salaries, job insecurity, and inconvenient administrative policies are why journalists leave their profession permanently. Additionally, a statistical test showed that the most significant issue is journalists receiving uncompetitive salaries, especially in Sindhi language newspapers. Furthermore, journalists working in the English language press tend to be pessimistic about their future in journalism. In contrast, Urdu language journalists are concerned about the threat to their lives, which is also a leading cause of job quitting. Keywords: Job leaving factor, newspaper journalist, administrative policy.
Metabolic and hormonal factors influencing high intensity exercise, recovery, and fatigue
Authors:   Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China., Tao Dan
Published: May 2023

The purpose of the paper is to consider the metabolic mechanisms contributing to high intensity exercise performance, recovery, and fatigue. A further purpose is also to consider the total stress response to exercise by outlining the catecholamine responses to exercise performance
Intraoperative electrocardiograph artifact mimicking ventricular tachycardia during a spine surgery
Authors:   Massachusetts General Hospital,USA, Wang Jingping
Published: May 2023

Ventricular Tachycardia (VT) is a dangerous form of arrhythmia that often warrants immediate treatment. We report here a case of intraoperative VT as a result of Electrocardiograph (EKG) artifacts during a spine surgery.
Kaposi Irgang disease: An entity not to ignore
Authors:   Hedi Chaker University Hospital, Sfax, Tunisia., Snoussi Mouna
Published: May 2023

Kaposi Irgang disease is a rare chronic from of cutaneous lupus. We describe a case of 28 years who was admitted for atrophic scars on both cheeks. The diagnosis of systemic lupus with chronic lupus profound was retained based on immunological and biopsy results. She was treated with hydroxychloroquine and referred to plastic surgery for lopfilling.
Man with betel nut toxicity
Authors:   FL/USVI Poison Information Center – Jacksonville, 655 w 8th Street, C-23, Jacksonville, FL 32209-6595, USA, Stott Molly K
Published: May 2023

A 36-year-old Burmese male was found unresponsive at his place of work with possible seizure-like activity. The patient received naloxone by Emergency Medical Services with no response. Upon ED arrival, the patient was tachycardic, hypertensive, with a Glasgow Coma Score of 3, and sluggishly reactive but equal pupils of 4 mm
Tympanic membrane cholesteatoma: A case report in an adult and a child
Authors:   Universidad Rey Juan Carlos, Madrid, Spain., Plaza Guillermo
Published: May 2023

Introduction and objective: Tympanic Membrane Cholesteatoma (TMC) is a rare pathology of unknown etiology which occurs more frequently in pediatric population, being the presentation in adults exceptional. Resection of the lesion is usually the surgical treatment through a transcanal approach.
A hypertensive emergency revealing renal artery stenosis with a negative echo-doppler: A case presentation and review of the literature
Authors:   Hospital university of Casablanca, Morocco., Bendahou H
Published: May 2023

Renal Artery Stenosis (RAS) occupies a prominent place among the secondary causes of arterial hypertension (HTA), in particular resistant.
Paucisymptomatic pulmonary tuberculosis in an immunocompetent young patient
Authors:   Centro Hospitalar Universitário de Lisboa Central., Inacio Hugo
Published: May 2023

This report presents the case of a 20-year-old student girl with no medical history, no usual medications, no known allergies and living in a clean and sanitary environment.
Outcomes of patients undergoing radical hysterectomy for early-stage cervical cancer at Bugando Medical Centre, Mwanza – Tanzania
Authors:   Catholic University of Health & Allied Sciences, 1464 Mwanza, Tanzania., Ndaboine Edgar
Published: May 2023

Background: Cervical cancer is the fourth most common cancer among women worldwide. In Tanzania, it is the leading malignancy in women with 58% of deaths reported annually. Radical hysterectomy is the recommended treatment for early stage cervical cancer, but this option only became available at Bugando Medical Centre (BMC) in 2014. The purpose of this study is to provide insight into the efficacy of gynecologic oncology surgery at BMC.
Worsening of autistic spectrum disorder symptoms after SARS-Cov-2 infection: A double mechanism hypothesis
Authors:   University Federico II of Naples, Via Sergio Pansini 5, Naples, Italy., Pia Riccio Maria
Published: May 2023

Autism Spectrum Disorder (ASD) is characterized by deficits in communication and social interaction, and restricted, repetitive movements and behavioural patterns. In this case report we would like to describe a worsening symptomatology of a patient affected by ASD following SARS-CoV-2 infection
Fatal hydatid cyst in a pregnant woman
Authors:   Shahed University, Tehran, Iran., Hossein Golezar Mohammad
Published: May 2023

In situations like peritonitis due to bile duct injuries drains insertion give an opportunity for healing. However in presented case the bile leakage from drains spontaneously stopped. Only constipation leads to icterus. A spontaneous choledoco enteric fistula explains these conditions, discovered later. It could be the result of inflammation causing adhesion.
Biografías petrarquistas hispanas y modelos autoriales de poetas en el siglo XVI
Authors: Pérez Pedro Ruiz
Published: May 2023

In the sixteenth century, four Petrarch vitae appear in separate editions of the poet, as a preliminary accessus. These are added to a previous manuscript, a translation of an exempt biography from the mid-fifteenth century. With their variants, the five texts make up a “Petrarch paradigm” that serves as an authorial image model for Hispanic followers of the Canzoniere. Thirteen years after the last of these biographies, that of Salusque Lusitano, Herrera composed Garcilaso’s life to open his edition. The comparative study of the resulting images illuminates one of the vectors of change proposed by the Sevillian in the introduction of a cultist poetic whose previous step is the decentering operation of the Garcilasian model.
Hacia una poética del espacio en “Miré los muros de la patria mía”
Authors: Villegas Simón Andrés
Published: May 2023

This article offers a reinterpretation of Quevedo’s sonnet “Miré los muros de la patria mía” based on the analysis of the textual mechanisms used by the poet to configure a unique poetic space. Starting off from one of the most recent works on this poem, which proposes its interpretation as an example of the poetry of ruins, I will try to demonstrate that Quevedo’s sonnet could be read as well within an interpretive framework that privileges the poem’s phenomenological aspects. From this perspective, “Miré los muros de la patria mía” makes a distinctive poetic proposal: an itinerant and spatial experience which ultimately looks for the reader’s involvement.
Psychometric Properties of Self-Compassion Scale-Short Form in a Turkish Young Adult Sample
Authors: BARUTÇU YILDIRIM Funda , ONAYLI Selin , TAŞKESEN Nureda
Published: May 2023

The current study aims to examine the psychometric properties of the Self-Compassion Scale-Short Form (SCS-SF) in a Turkish young adulthood sample. The study participants comprised 139 Turkish university students in Study 1 and 200 Turkish university students in Study 2. The SCS-SF was translated into Turkish; experts examined the translation studies to check the content validity. Confirmatory factor analyses were conducted to investigate construct validity in both studies. As with the long version, a six-factor and a single higher-order factor structure of the Shortened Self-Compassion Scale were confirmed in both study 1 and study 2. To check convergent validity, the scores of SCS-SF were compared with the Mindful Attention Awareness Scale and the Positive and Negative Affect Schedule scores significant correlations were found. Reliability analyses were conducted to test internal and test-retest reliability and generally yielded acceptable reliability estimates. Thus, as a reliable and valid instrument, the Self-Compassion Scale-Short Form can be used to measure the self-compassion level of Turkish young adults as an alternative to the long version of the SCS.
O restaurador-conservador no âmbito da conservação e do restauro de obras de arte
Authors: Monteiro Ilda
Published: May 2023

Este trabalho tem como objetivo o estudo na área da conservação e restauro das obras de arte, cujos fatores citados ao longo do trabalho estão associados à degradação e à deterioração que podem ser provocados por causas físicas e ambientais.

O objetivo principal do conservador funciona como modelo de avaliação na assistência a espaços museológicos e galerias com a implementação de soluções técnicas viáveis para a sua conservação e salvaguarda do património.  O restaurador requer não só uma profissionalização e especialização, mas também uma interdisciplinaridade e capacidade de trabalho especializado em grupo pelos responsáveis conservadores.  Este processo resulta da segurança e preservação das coleções com determinadas condições ambientais e a requisição de peritos e meios técnicos de avaliação.
e-Music:
Authors: Maeso Benito Eduardo , Vivan Alexandre Tarik
Published: May 2023

A Electrónica (também conhecida como e-music) caracteriza-se pela utilização de instrumentos e equipamentos electrónicos para produzir sons e harmonias sintetizados e não naturais. Teve origem nas mudanças de paradigmas estéticos e epistemológicos ocorridas no final do século XIX e início do século XX. Além disso, a e-music reflecte a crise representacional e ontológica dos objectos de Arte. Tendo este pano de fundo como ponto de partida, este ensaio pretende investigar a produção da arte contemporânea e, especificamente, da música electrónica, sob o escrutínio de duas chaves analíticas: as imagens técnicas de Flusser e Benjamin e o conceito freudiano de "unheimlich". A questão que norteia esta investigação pode ser retomada a seguir: a soma das suas características (a sua construção e arranjos em camadas, a utilização de ruídos, samples e recursos experimentais e não-humanos) permite à música electrónica gerar sensações de desconforto ou de deslocação e, simultaneamente, evocar uma atmosfera familiar e calorosa? Em caso afirmativo, é necessário estabelecer um conjunto de relações entre a Estética, a Psicanálise e a Filosofia da Técnica.
Anxiety and Violence Against Nurses in Turkey During The COVID-19 Pandemic
Authors: Senol Celik Sevilay , Bulut Hulya , Atali Ozbas Azize , Karahan Azize , Koc Gulten , Ozdemir Ozleyen Cigdem , Cevik Aydin Firuze , Celik Beyhan , Mercan Annak İnci , Celik Yusuf
Published: May 2023

During the pandemic process, nurses felt more anxious and nervous compared to other health professionals and were frequently exposed to verbal-emotional-psychological violence. This study was conducted to determine the anxiety levels of nurses, their exposure to violence, and the factors affecting the anxiety and witnessed violence of nurses during the COVID-19 pandemic in Turkey. The descriptive study data were collected in the period between October 2020 and March 2021 via the online questionnaire published on the Turkish Nurses Association’s website. The study sample consisted of 3,230 nurses. In this study, it was found that the majority of participants in the study were women (83,5%), working 24-hour shifts (49.3%) at hospitals run by the Ministry of Health (68.7%), caring for COVID-19 patients (82.1%). Nurses experienced very high levels of anxiety and were exposed to violence from patients, family members, or other healthcare professionals during the COVID-19 pandemic. Also, this study shows that nurses experienced high anxiety levels and increased exposure to violence in association with the high number of patients to provide care for, long working hours, being forced to work despite COVID-19 symptoms, working with COVID-19 patients, the fear of infecting family members, having difficulties in caring for family members, financial losses, and the unavailability of changing rooms. In line with the results of this study, the responsibility range of managers and decision-makers is wide in protecting the physical and mental integrity of nurses, anticipating, and addressing their needs and resolving their problems, and managing the nurse manpower and the supply of PPE in accordance with standards so that nurses can provide qualified and safe nursing practices. The findings of this study will help to ensure that nursing care is safe, consistent, and competent, as well as guide future planning.
Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage
Authors: Park Seul Gi , Yang Hyo Ju , Lim Soo Yeon , Kim Seh Hyun , Shin Seung Han , Kim Ee-Kyung , Kim Han-Suk
Published: May 2023

Purpose: Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay in preterm infants. Severe IVH is known to have a poor outcome; however, the outcomes of low-grade IVH remain controversial. This study aimed to evaluate neurodevelopmental outcomes and brain segmental volumes of preterm infants with low-grade IVH.Methods: This retrospective cohort study included 109 extremely preterm infants who underwent term equivalent age-magnetic resonance imaging and neurodevelopmental evaluation at a corrected age of 18 to 24 months. We compared infants with and without low-grade IVH.Results: Among the 109 extremely preterm infants, 25 had low-grade IVH and 84 had no IVH. There were no significant differences in the neurodevelopmental outcomes between the low-grade and no IVH groups. In multivariate analysis, low-grade IVH was associated with a smaller medullary volume (adjusted odds ratio, 0.575; 95% confidence interval, 0.346 to 0.957; P=0.034).Conclusion: We found no significant differences in the neurodevelopmental outcomes of extremely preterm infants at a corrected age of 18 to 24 months between those with low-grade IVH and those without IVH. Low-grade IVH was associated with a smaller medullary volume.
Pengembangan E-Modul Matematika Interaktif Berbasis Augmented Reality Pada Materi Bangun Ruang
Authors: Buchori Achmad , Prasetyowati Dina
Published: June 2023

Penelitian ini bertujuan untuk mengembangkan e-modul interaktif matematika pada materi lingkaran kelas VIII. Metode penelitian yang digunakan pada penelitian ini yaitu Research and Development (R&D), dan model yang digunakan yaitu model pengembangan 4-D, namun pada penelitian ini hanya sampai pada tahap 3-D saja yang meliputi: tahap pendefinisian (define), tahap perancangan (design), dan tahap pengembangan media (develop). Penelitian ini menggunakan uji validitas ahli media oleh dosen dan uji validitas ahli materi oleh guru Matematika dengan menggunakan skala likert dan prosentase validasi. Hasil validasi ahli media didapatkan rata-rata nilai validasi sebesar 3,71 dan prosentase validasi sebesar 92,74, sedangkan hasil validasi ahli materi didapatkan rata-rata nilai validasi sebesar 3,87 dan prosentasi validasi sebesar 96,7. Sehingga dapat disimpulkan bahwa e-modul interaktif berbasis AR matematika pada materi geometri untuk kelas VIII teruji kevalidan dan kelayakannya.
Diversifikasi Produk Keuangan Pasca Merger (Studi Kasus Bank Syariah Indonesia)
Authors: Agrosamdhyo Raden
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana diversifikasi produk yang dilakukan oleh Bank Syariah Indonesia pasca merger untuk menarik nasabah. Metodologi penelitian yang digunakan adalah penelitian kualitatif deskriptif. Informan dalam penelitian ini adalah pegawai Bank Syariah Indonesia Cabang Denpasar dengan menggunakan teknik purposive. Serta pengumpulan data berupa wawancara dan dokumentasi. Penelitian ini memaparkan hasil diversifikasi produk yang dilakukan oleh Bank Syariah Indonesia pasca merger untuk menarik nasabah yaitu dengan meluncurkan produk BSI yang diluncurkan yang belum ada di bank sebelumnya yaitu agen pintar Imas dan BSI. Verifikasi yang dilakukan oleh bank syariah Indonesia lebih efektif dalam meningkatkan minat nasabah yang semakin meningkat setiap bulannya dan juga cocok untuk memperluas pangsa pasar.
UPAYA MENGEMBANGKAN KETERAMPILAN MEMBACA ANAK USIA 5-6 TAHUN MELALUI MEDIA GAMBAR DI RA AL MANSHURIAH
Authors: Mukhtar Mukhtar
Published: June 2023

Tujuan penelitian ini yaitu untuk meningkatkan kemampuan membaca dini pada anak usia 5-6 tahun  melalui media gambar di RA Al Manshuriah tahun pelajaran 2022/2023, adapun pertanyaan penelitian sehingga rumusan masalah dari penelitian ini adalah 1) Bagaimana cara meningkatkan kemampuan membaca dini anak usia 5-6 melalui media gambar di RA Al Manshuriah 2) Apa saja hambatan Meningkatkan Kemampuan Membaca Anak Usia 5-6 Tahun dengan menggunakan media gambar di RA Al Manshuriah tahun pelajaran 2022/2023. Untuk menjawab pertanyaan penelitian tersebut peneliti merancang penelitian dengan menggunakan jenis dan metode kualitatif, dari penelitian ini usia anak 5-6 tahun pada RA Al Manshuriah tahun pelajaran 2022/2023, untuk mengumpulkan data peneliti menggunakan tekhnik observasi, wawancara, dokumentasi, selanjutnya menggunakan analisis data. Hasil dari penelitian ini menunjukkan bahwa upaya meningkatkan kemampuan membaca dini dengan menggunakan media gambar pada RA Al Manshuriah tahun pelajaran 2022/2023 sudah tepat yaitu dengan metode belajar sambil bermain, hal ini dibuktikan dengan hasil skor anak pada observasi ke dua yaitu Dari hasil observasi kedua menunjukan bahwa anak yang tingkat kemampuan membaca terdapat 9 orang anak berkembang sesuai harapan (BSH) 62,5%. 5 orang anak mulai berkembang (MB) 31,25%, dan 1 orang anak yang belum berkembang (BB) 6,25% . sesuai dengan factor-faktor pendukung yaitu metode yang menantang dan merangsang serta kepedulian seorang guru terhadap anak, adapun hambatan-hambatan yang dihadapi yaitu  rasa ketertarikan anak terhadap guru masih kurang, tidak ada sinergi guru dengan sekolah, kerjasama antara guru dengan orang tua anak masih belum maksimal, sebagai alternative dari hambatan-hambatan tersebut adalah guru menghadirkan  model-model pembelajaran yang menantang peduli terhadap nuansa dalam pembelajaran, menunjukkan kepribadian yang positif dengan menanamkan nilai-nilai agama.
Komparasi Efektivitas Pembelajaran Daring dan Luring MA Al-Amin Tahun Pelajaran 2021/2022
Authors: Arifin Haris Nursyah , Ismail Syarof Nursyah
Published: June 2023

Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas antara pembelajaran daring dan luring MA Al-Amin Tabanan Tahun Pelajaran 2021/2022. Metode penelitian yang digunakan yakni metode kualitatif dengan pendekatan kualitatif deskriptif dengan teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Informan pada penelitian ini yaitu Kepala Madrasah, Wakil Kepala Bidang Kesiswaan, Guru, Siswa, Orang tua dan Komite MA Al-Amin Tabanan. Hasil dari penelitian ini yakni pembelajaran luring lebih efektif dibandingkan pembelajaran daring dilihat dari keempat indikator efektivitas pembelajaran yaitu mutu pengajaran, tingkat pengajaran yang tepat, insentif dan penggunaan waktu belajar. Pembelajaran luring lebih efektif karena secara umum guru dapat mengontrol secara langsung proses pembelajaran di sekolah. Sedangkan pembelajaran daring kurang kontrol dari guru serta orang tua sehingga siswa kurang dalam menerapkan kedisplinan diri.
UMKM Indonesia Menuju Industri Halal Dan Go Digital Dalam Memasuki Pasar Global
Authors: Kusjuniati Kusjuniati
Published: June 2023

Permasalahan utama yang dihadapi oleh UMKM adalah pertama tentang sertifikasi halal dimana pada tahun 2024 seluruh UMKM di Indonesia wajib memiliki sertifikat halal dan go digital dalam operasional usahanya. Tujuan penulisan ini untuk mengetahui jumlah UMKM yang telah memiliki sertifikasi halal dan telah go digital. Metodologi penulisan menggunakan pendekatan kualitatif. Melalui penelitian kualitatif ini dimungkinkan  untuk diperoleh pemahaman tentang kenyataan melalui proses berpikir induktif. Pemerintah berharap Indonesia bangkit ekonominya dengan  mendorong UMKM untuk memberikan keyakinan pada konsumen dalam negeri maupun luar negeri dalam memproduksi produk-produk halal yang diharapkan makin meningkat dan menjadi yang terbesar di dunia menembus pasar dunia. Tujuan pemberian sertifikasi halal pada produk-produk yang dihasilkan oleh UMKM adalah agar UMKM Indonesia bisa bersaing di pasar global. Digitalisasi memberikan peluang untuk mempertahankan kelangsungan UMKM, dengan membuka pasar baru. Bila UMKM sudah go digital maka akan memiliki daya saing yang tinggi untuk memasuki pasar global.
Strategi Pengelolaan Dan Peran Koperasi Alfa Salam Untuk Kesejahteraan Ekonomi Masyarakat Di Sekitar Pondok Pesantren Syafa’ah Darussalam Denpasar
Authors: Iswahyuni Iswahyuni
Published: June 2023

Tujuan penelitian ini adalah: 1. Untuk mengetahui strategi pengelolaan koperasi Alfa Salam Pondok Pesantren Syafa’ah Darussalam 2. Untuk mengetahui peran koperasi Alfa Salam Pondok Pesantren Syafa’ah Darussalam bagi kesejahteraan masyarakat sekitar. 3. Untuk mengetahui kesejahteraan ekonomi masyarakat di sekitar Pondok pesantren Syafa’ah Darussalam dengan adanya koperasi Alfa Salam. Penelitian ini menggunakan penelitian kualitatif deskripif. Informan dalam penelitian ini ada 9. Serta teknik pengumpulan data berupa: observasi, wawancara, dan dokumentasi. Berdasarkan hasil penelitian yaitu bahwa dalam strategi pengelolaan koperasi Alfa Salam banyak masalah internal yang harus diperbaiki dan kurangnya anggota yang ahli dalam mengurus koperasi Alfa Salam mengakibatkan koperasi Alfa Salam terhambat dalam perkembangan koperasi.  Apabila peran koperasi Alfa Salam terlaksana seperti kesejahteraan para anggota dan masyarakat sekitar maka tujuan koperasi Alfa Salam akan terwujud yaitu mencapai kepuasan konsumen dan membangun sumber daya insani yang professional. Karena adanya koperasi Alfa Salam kebutuhan santri dan masyarakat sekitar jadi terpenuhi serta masyarakat bisa menitipkan dagangannya ke koperasi sehingga kesejahteraan ekonomi masyarakat sangat terbantu oleh adanya koperasi Alfa Salam.
Meningkatkan Disiplin Kinerja Guru Pada Masa Pandemi Melalui Supervisor Pengajaran
Authors: Soedjiwo Novena Ade Fredyarini
Published: June 2023

Penelitian ini dilatarbelakangi oleh tanggungjawab kepala sekolah sebagai pengawas yang bertugas menyusun, melaksanakan, dan menggunakan hasil pengawasan untuk meningkatkan kegiatan pembelajaran dan pendidikan. Kepala sekolah memegang peranan penting dalam mengontrol kemajuan suatu sekolah. Pengawasan dilakukan untuk membantu guru dalam melaksanakan pembelajaran daring bagi siswa di masa pandemi. Kondisi tersebut tidak membuat guru kehilangan tanggung jawab atas tugas dan kewajibannya serta malas untuk bersekolah. Hal ini tidak terlepas dari peran kepala sekolah dalam melakukan pembinaan terhadap sekolah. Untuk mengetahui peningkatan kinerja guru dan kedisiplinan di masa pandemi melalui supervisi pengeajaran. Tujuan dari penelitian ini adalah; untuk mngetahui cara meningkatkan disiplin kinerja guru di masa pandemi melalui pengawas mengajar dan solusi yang dilakukan kepala sekolah untuk meningkatkan disiplin kinerja guru di masa pandemi melalui pengawas mengajar. Metode penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan lapangan (field research), dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian ini akan dideskripsikan secara deskriptif. Hasil penelitian menunjukkan: kemampuan kepala sekolah sebagai pengawas dalam melaksanakan, menyusun dan mengevaluasi guru dalam mengoptimalkan disiplin kerja guru melalui aturan dan peraturan jadwal supervisi serta melakukan evaluasi dan memberikan arahan terhadap guru yang kurang kompeten. Kebijakan kepala sekolah dalam kedisiplinan kepada bawahan, menegur guru yang tidak disiplin, melakukan evaluasi kerja dengan memberikan arahan, kritik dan saran.
RESILIENSI PELAKU USAHA PARIWISATA PADA MASA PANDEMI DI KAWASAN OBJEK WISATA CANGGU, KABUPATEN BADUNG
Authors: Widyastuti Ni Kadek , Artana I Nengah Rata , Edy Raden Agus Sarwa
Published: June 2023

Obyek wisata merupakan bagian penting dari pariwisata dimana dari pemasukan yang dihasilkan akan berdampak pada perekonomian masyarakat.  Penelitian ini dilakukan agar dapat melihat resiliensi atau kemampuan pelaku usaha dalam mengatasi kesulitan pada masa pandemi , Penelitian ini menggunakan metode penelitian kualitatif, penelitian ini bertujuan untuk  mengetahui  Resiliensi  Pelaku Usaha Pariwisata Pada Masa Pandemi Di Kawasan Objek Wisata Canggu, Kabupaten Badung. Pengambilan sampel pada penelitian ini     menggunakan purposive sampling. Hasil penelitian ini menunjukkan masyarakat Canggu resilience terhadap adanya pandemi. Warga Canggu selain memilih untuk bertahan dengan pekerjaannya ada juga sebagian yang memilih untuk mencari pekerjaan lain agar dapat memenuhi kebutuhan hidupnya.
Improving the Executive Functions of Third to Fifth Graders With Learning Disabilities Through an Expressive Writing Program: The Case of Working Memory, Planning/Organizing, and Cognitive Flexibility
Authors: Kamran Leila , Dehghani Yousef , Dehghani Mostafa
Published: June 2023

Students with learning disabilities face more educational and even adult life difficulties than their counterparts without such disabilities, because of their poorer executive functioning. This study explored the effects of a disclosure program for expressive writing about emotions on the 3 executive functions of working memory, planning/organizing, and cognitive flexibility in an Iranian context. In so doing, 40 third to fifth graders with learning disabilities were recruited and assigned to either experimental or control groups through certain recognition tests and interviews. The effects of the treatment on executive functions were stable after 2 months. It was concluded that such disclosure programs can reduce executive functioning impairments of students with learning disabilities.
DIFFERENCES IN THE HINDLIMB ANATOMY IN THE TWO SPECIES OF THE LATE TRIASSIC DREPANOSAUROMORPH DIAPSID MEGALANCOSAURUS INDICATE HABITAT PARTITIONING WITHIN THE ARBOREAL ENVIRONMENT
Authors: RENESTO SILVIO , SALLER FRANCO
Published: May 2023

Discovery of two different morphologies of the hindlimb in specimens ascribed to the Triassic drepanosauromorph diapsid Megalancosaurus led to the erection of two distinct species within this genus: M. preonensis and M. endennae. In the present study a re-examination of the hindlimb architecture of both Megalancosaurus species indicates that M. preonensis and M. endennae exploited different microhabitats within the arboreal environment as for many extant species belonging to the same genus, like caribbean Anoles. M. endennae, with a stronger lower leg, a larger grasping foot, an opposable clawless hallux, and deeper and more recurved claws on pedal digits 2-5 was better adapted for locomotion on narrow and intricate supports like narrow twigs on terminal branches. M.preonensis with more slender hindlimbs, absence of an opposable hallux and longer, but thinner and less recurved claws on all pedal digits may have been better adapted to live on larger supports and could also have used the long pedal claws as hooks in a sloth-like fashion. In both Megalancosaurus species the tail acted both as a prop to assume a stable tripodal gait and as a clinging device that ensured grip during bridging as in other arboreal drepanosauromorphs which skeleton is adequately known. The overall hindlimb adaptation of Megalancosaurus species are more similar to that of some small arboreal mammals rather than that of chameleons.
Variations in Kiwifruit Microbiota across Cultivars and Tissues during Developmental Stages
Authors: Kim Su-Hyeon , Kim Da-Ran , Kwak Youn-Sig
Published: June 2023

The plant microbiota plays a crucial role in promoting plant health by facilitating the nutrient acquisition, abiotic stress tolerance, biotic stress resilience, and host immune regulation. Despite decades of research efforts, the precise relationship and function between plants and microorganisms remain unclear. Kiwifruit (Actinidia spp.) is a widely cultivated horticultural crop known for its high vitamin C, potassium, and phytochemical content. In this study, we investigated the microbial communities of kiwifruit across different cultivars (cvs. Deliwoong and Sweetgold) and tissues at various developmental stages. Our results showed that the microbiota community similarity was confirmed between the cultivars using principal coordinates analysis. Network analysis using both degree and eigenvector centrality indicated similar network forms between the cultivars. Furthermore, Streptomycetaceae was identified in the endosphere of cv. Deliwoong by analyzing amplicon sequence variants corresponding to tissues with an eigenvector centrality value of 0.6 or higher. Our findings provide a foundation for maintaining kiwifruit health through the analysis of its microbial community.
Proteomic and Phenotypic Analyses of a Putative YggS Family Pyridoxal Phosphate-Dependent Enzyme in Acidovorax citrulli
Authors: Heo Lynn , Cho Yongmin , Choi Junhyeok , Lee Jeongwook , Han Yoobin , Han Sang-Wook
Published: June 2023

Acidovorax citrulli (Ac) is a phytopathogenic bacterium that causes bacterial fruit blotch (BFB) in cucurbit crops, including watermelon. However, there are no effective methods to control this disease. YggS family pyridoxal phosphate-dependent enzyme acts as a coenzyme in all transamination reactions, but its function in Ac is poorly understood. Therefore, this study uses proteomic and phenotypic analyses to characterize the functions. The Ac strain lacking the YggS family pyridoxal phosphate-dependent enzyme, AcΔyppAc(EV), virulence was wholly eradicated in geminated seed inoculation and leaf infiltration. AcΔyppAc(EV) propagation was inhibited when exposed to L-homoserine but not pyridoxine. Wild-type and mutant growth were comparable in the liquid media but not in the solid media in the minimal condition. The comparative proteomic analysis revealed that YppAc is primarily involved in cell motility and wall/membrane/envelop biogenesis. In addition, AcΔyppAc(EV) reduced biofilm formation and twitching halo production, indicating that YppAc is involved in various cellular mechanisms and possesses pleiotropic effects. Therefore, this identified protein is a potential target for developing an efficient anti-virulence reagent to control BFB.
The Application of CAR-T Cell Therapy
Authors: Yu Wenyi
Published: May 2023

Cancer is undoubtedly the number one killer in today's society. Traditional surgical treatment methods have their own limitations, especially in the treatment of end-stage or hematological tumors. Emerging immunotherapy is an unprecedented breakthrough technology in cancer treatment. For example, PD-1/PD-L1 and CAR-T immunotherapy. CAR-T has been proposed for many years, it is only in the last few years that it has been improved and applied in the clinic. Its effectiveness in the treatment of cancer in hematology is encouraging. For example, it has a great curative impact in the acute leukemia, in the field of non-Hodgkin lymphoma ,it is also recognized as one of the most prospective and developed tumor treatments. Clinical application of CAR-T has attracted extensive attention. This therapy is characterized by the ability to detect tumor-associated antigens preferentially detected by T cells, which has a significant anti-tumor effect. This article will focus on HCC, list the existing HCC CAR-T treatment targets and briefly describe associated clinical research.
DNA Data Storage: The Fusion of Digital and Biological Information
Authors: Li Xiao
Published: May 2023

With the development of Internet technology, human information data grows by a huge amount. Traditional data storage media are no longer suitable for large amounts of data storage due to their inherent shortcomings, such as high power consumption, large physical size, and short storage life. DNA information storage, on the other hand, can overcome these shortcomings to a certain extent. This paper introduces the process and mechanism of DNA storage, such as the DNA synthesis method, DNA coding, DNA preservation and sequencing, the history of DNA storage, its defects, and shortcomings. This article introduces the principles and mechanisms of DNA storage, including DNA synthesis method, data storage, and DNA preservation, as well as the history of DNA storage and its shortcomings and prospects for improvement, using the comparison of traditional storage methods and DNA storage methods as an import cut.
The Role of A High-Carbohydrates Diet on Alzheimers Disease
Authors: Wu Caiying , Zhang Mengxi , Zhou Shuyi , Zhong Xiaolei
Published: May 2023

Brain diseases, like majority illnesses, are influenced in some way by nutrition. Alzheimers disease, which is characterized by brain cell deaths and memory loss, is significantly influenced by sugar intake. The frequency, quantity, and type of carbohydrates can influence AD development and outcomes. Whether highly processed or not, carbohydrate-rich foods influence AD. This paper discusses how a high-carbohydrate diet increases the chances of AD development and aggravation. General introduction to carbohydrate diets and the etiology of AD are explained. Subsequently, details on nonmodified and modified AD risk factors are addressed. The present paper moreover examines the imperative relationship between AD and high-carbohydrates diets. Particularly, the paper elucidates how: carbohydrate-rich diets impair cognitive function; how the diet aggravates AD ramifications. Furthermore, the paper evaluates how high-carbohydrates diets: alter AD biomarkers; interact with age to influence AD; and how carbohydrate-rich diets prevent brain cell growth and repair. The report addresses the prevailing therapeutic methods that can be employed to prevent and manage Alzheimers disease. Such interventions include the use of caffeine to significantly less cognitive deterioration in AD patients is addressed. Other interventions addressed regard how ketogenic diets can effectively aid with AD prevention; minimal sugar consumption; and how physical activities can aid AD prevention and management. Besides, AD-derived diseases are also addressed. The paper finds that high-carbohydrate diets should be avoided, and healthier lifestyle practices are integral for AD prevention and management.
Effects and mechanism of L-Carnitine on weight loss
Authors: Liu Xiaotian
Published: May 2023

L-Carnitine, as an essential coenzyme in fat metabolism, can promote the metabolism of human fat, accelerate the burning of fat, and may achieve the desired fat burning slimming effect; This papers studies the effect of L-carnitine on weight loss and the possible side effects it may bring to the human body, explains the weight loss principle and metabolic pathway of L-carnitine from the molecular level, and discusses the relationship between exercise and L-carnitine in combination with metabolism, give the author recommendations for using L-Carnitine. A brief explanation of the current state of development of L-carnitine diet pills (supplements) in the field of health was described. Combined with the comparison and summary of existing databases, it is concluded that L-carnitine alone is not an ideal choice, and L-carnitine alone is used without exercise: For people with normal weight, L-carnitine has no effect on weight loss. Obviously, only overweight, and obese people, taking L-carnitine combined with a lot of training have obvious weight loss effect.
Comparison of Epidemic Prevention Measures for Different Levels of Infectious Diseases Taking SARS and COVID-19 as Examples
Authors: Gao Yutang
Published: May 2023

Currently, the prevention and control measures are routinely implemented, which is not exactly the same as the situation of SARS. This paper compares China's different epidemic prevention measures against SARS and COVID-19 by analyzing previous literature. Both SARS and COVID-19 employed similar strategies, such as centralized isolation and treatment and regular case screening of citizens, but the degree of implementation of strategies during SARS was less than ideal for COVID-19 due to the technical limitations of the time. Government regulation and the use of advanced technologies are critical to controlling infectious diseases. The protection strategies that have been implemented have effectively mitigated the damage to society caused by the epidemic.
Drug Discovery and Development of Recently Approved Drugs: Tisotumab Vedotin
Authors: Long Hongzhu , Ma Boxuan , Shi Mingyu , Zeng Xuetong
Published: May 2023

Recurrent or metastatic cervical cancer is the primary reason for dying in the female population. Although advanced research in immunization may provide a potential treatment for cervical cancer, it is still one of the usual fetal female cancers globally. Previous studies on bevacizumab and chemotherapy provided efficient treatments with a survival benefit for women, but different strategies are needed to increase the overall survival rate of this cancer. Tisotumab vedotin is an investigative and pioneering immunoglobulin-medicine combination that targets tissue factor (TF), a protein in high concentrations in various solid tumours. Tisotumab vedotin bonds to tissue factor on aimed cells and then releases monomethyl auristatin E (MMAE). In addition, Tisotumab vedotins direct cytotoxicity may increase nearby tumour cells spectator toxicity and various immune-linked effects. This paper will discuss previous studies on Tisotumab vedotin, and their data will be analyzed further. The improvement toward this treatment will be proposed as well. This paper aimed to establish a thorough understanding and further analysis of the previous clinical trials and findings on Tisotumab vedotin.
Recent Progress on Non-invasive Wearable Epidermal Biosensors
Authors: Li Bowen
Published: May 2023

Wearable biosensors have the potential to provide valuable information about our physiological states and transform traditional healthcare. Compared to traditional blood sampling, on-body analysis of non-invasive biofluids can offer continuous and painless monitoring of relevant biomarkers. Recent developments in epidermal sensors feature integrated systems capable of sensing multiple factors while providing easy readout and great skin conformity. Innovative solutions based on advanced material fabrication and novel designs have also emerged to address challenges such as power, sensor sensitivity and selectivity, and communication. As a result, more possibilities have emerged to develop sophisticated integrations with more functionalities, optimized skin conformity, and less disruption of daily routine. While sensing performance and functions continue to improve, attention should also be drawn to practical problems such as biofouling, contamination, and complex composition dynamics. Moreover, although past and current research have highlighted studies investigating the use of sweat in diagnostics, more evidence of correlations between sweat biomarker levels and physiological conditions is needed to promote the utility of these systems.
Alzheimers Disease Mechanism in Neuroimmunology Perspective
Authors: Hao Jing
Published: May 2023

Among the several neurodegenerative illnesses, one of these is the illness Alzheimer's (AD). it is hard to cure completely for now. To find fresh targets for the therapy of AD, neuroimmunology have been getting attention gradually. Neuroimmunology response, which happened in the central nervous system (CNS), is innate immune response of human. In the AD, microglia activated by damage signals lead to a series of cellular cascade responses. Then, a large number of chemokines and inflammatory cytokines are released by microglial cells. The cytokines have neurotoxic effects on the certain brain areas, causing neuronal degeneration. Since microglia can be activated by tau aggregation in addition to alarm signals, with tau protein aggregation releasing from the degenerative neurons, it provokes a positive feedback mechanism of neuroimmunology in hippocampal area. Microglia mainly play a role of neuroprotective by clearing -amyloid (A) on early stage of AD and have a neurotoxic effects induced by an A-induced phenotypic change on late stage of AD. TREM2 mainly expressed on microglia, it may downregulate the inflammatory response in AD. The review has explained clearly and demonstrated that tau assembly and clearance of A are effective therapeutic targets on AD. In addition, it explained AD nosogenesis from the new view of TREM2 mutations.
The applications of supramolecules in biological cells
Authors: Peng Kailin
Published: May 2023

A supramolecular structure is an ordered aggregate formed by intermolecular forces, also known as Van der Waals forces, and does not have to be covalent bonds. By combining with molecule with different structure, the supramolecule will show as a molecular collection with complex shape. It allows a supramolecule to have multiple characteristics and assume multiple functions. Without the need to synthesize by artificial initiative, supramolecules are widely apply in the biological field naturally. Many biological macromolecules are considered as one kind of supramolecules. These macromolecules can combine to form aggregations and, further, cell organelles, as well as collaborate to produce a series of biological reactions. Since supramolecules are a broad and cross majors research with rapid progress, it is necessary to regularly review, integrate and discuss this topic. Therefore, this review will discuss the present of supramolecules and analyze of application of supramolecules in cells. Recent research about how specific supramolecules apply and work for the particular function will be introduced.
Climate Change and the Change of Trophic Level Interaction in Coral Reefs Based on South China Sea in China
Authors: Cai Qiqi , Du Yiqing , Qu Fenghao , Wang Minghao
Published: May 2023

In recent years, coral reefs have been seriously affected by human and natural factors, some of influences are even irreversible. Among them, the impacts of climate change have gradually deepened and attracted people's attention. Other papers which tell about the familiar topic failed to focus on discussing specific questions in certain area of coral reefs. The paper mainly analyzes the interspecific relationship change when facing the climate change of coral reef ecology in the South China Sea. Content of this paper first discusses the severe condition of climate change, like the instability of global climate system. Also, the situation about South China Sea and the effects of climate change are discussed and analyzed. Then, the interspecific relationships of predation, competition, parasitism, and mutualism were discussed. Further, discussed the increase of benthic algae and symbiotic organism reactions. The response from higher trophic level to low level and some researches are determined, too. On this basis, consider the interspecific relationships in the same trophic level. In the future, higher trophic level changes should be determined. Also, people should focus on the change after coral reefs recovering from albinism, about whether their population would change even extinct with the effect of climate change on coral reefs and reefs make a response to it through trophic level relationship change. This paper can provide some corresponding research ideas for more future researches.
Single-Lead ECG Signal Collecting System Design
Authors: Zhu Qingjun
Published: May 2023

The purpose of these experiments is to understand the function and importance of an electrocardiogram (ECG). In general, an electrocardiogram experiment entails tests conducted to evaluate the hearts rhythm and electrical activity. The laboratory activities involved building the circuit required for recording the electrocardiogram, and the respective ECG signals were effectively converted for clearer observation. The experiment objective was achieved through the following procedures in the lab manual. MATLAB software was effectively used to obtain the plot for the ECG signal by exploiting the data obtained from the acquisition software. The report also successfully provides a compelling discussion on electrocardiograms and their general importance. After acquiring effective ECG plots, the laptop was effectively connected to the acquisition system and the obtained plot was employed for effective analysis.
Links between Serotonin and Depression
Authors: Li Betty
Published: May 2023

Serotonin is a common neurotransmitter linked closely with the feeling-good effects, while the dysregulation of serotonin could lead to the major depressive disorder which affect 350 million peoples lifetime all over the world. The synthesis of serotonin is stimulated by its precursor tryptophan. It is an important type of amino acid found in dietary protein. Fur-thermore, low level of serotonin could lead to lack of melatonin. This indicates the various symptoms caused by depression.
The Current Study and Potential Treatment of Drug Abuse
Authors: Liu Dangqing
Published: May 2023

It has been a long time since China started to strictly control drug transaction and usage. There are increasing compulsory detoxification institution, institutions to do voluntary de-toxification, and community drug treatment rehabilitation. These detoxification institutions implement medication detoxification, psychological detoxification, and doing moral & physical education, aiming at helping the rehabilitation personnel and reduce the relapse rate after getting treatment in the compulsory detoxification institution. To avoid reoccur-rence and suffering from a long-term imprisonment for drug control, biomedical research to improve drug abuse treatment and addiction prevention are in need. This paper is going to summarize the previous and ongoing research on the mechanisms of addiction, together with the approaches of the drug abuse treatment to state some analysis and suggestion about the scientific ways to help drug rehabilitation to find more effective and efficient ways for the treatment of drug abuse to decrease the relapse rate and rehabilitated time.
Research on sexually transmitted infections - taking HIV as an example
Authors: Guo Zhirui
Published: May 2023

In today's society, there are still a big number of sexually transmitted infection carriers. A range of sexually transmitted illnesses, such as gonorrhea, syphilis, and others, are continually harming people's life as a result of all kinds of bad living practices and styles. This research employs case study and comparative methodologies to investigate the origins of these STDs in the context of HIV, how they develop, the many routes of infection, and the diverse repercussions on society and people. Following the sorting of the gathered data, multiple models employed in the relevant literature were compared and selected to choose the best model for further study. Furthermore, many preventive actions and solutions are recommended based on the model's conclusions, including how to protect neonates from congenital STDs. Our findings indicate that frequent screening is critical for eradicating local epidemics and that condom marketing initiatives are only effective when accompanied with screening. The results of our research were then extended using Monte Carlo simulations to better understand the function of partner networks and partner notifications as markers of STI control.