bluuebunny/crossref_metadata_2025 huggingface dataset:
Um mosaico de experiências no Ciclo de Conversas sobre Café e Hospitalidade
Authors: Carvalho Tavares Beatriz , Nunes de Oliveira Alini , Marroni Minasi Sarah
Published: December 2021

O evento Ciclo de Conversas sobre Café e Hospitalidade busca trazer à luz os debates e interfaces do café. O evento teve sua primeira edição em outubro de 2020 e continuação com a segunda edição em maio de 2021, de forma on-line e gratuita sob a premissa de ser um evento realizado por mulheres e com mulheres. A partir da realização das duas edições foi identificada a necessidade de compartilhar as práticas de educação não-formal vivenciadas. Para isso, este trabalho tem como objetivo apresentar os debates envolvidos na disseminação dos estudos e atuações na área do café e da hospitalidade protagonizados por mulheres. A metodologia escolhida foi de relato de experiência. As convidadas foram pesquisadoras e trabalhadoras da cadeia do café, abordando temas como gastronomia, nutrição, história, patrimônio, arte, turismo, produção e consumo, hospitalidade, etnicidade e máquinas. Ao todo, as duas edições contaram com 13 encontros, 29 convidadas e dois convidados, de sete estados e o Distrito Federal. A realização do Ciclo se caracteriza como um ambiente para debate amplo sobre o tema do café em uma perspectiva antirracista, decolonial, democrática, feminista e agroecológica. O compartilhamento de experiências abre para outras formas de aprendizagem interdisciplinar e não-formal.
Reflexões sobre o imaginário na arte literária de José Saramago: uma leitura interdisciplinar de A jangada de pedra
Authors: Baseio Maria Auxiliadora Fontana , Cunha Maria Zilda da
Published: December 2021

Se, de acordo com Gilbert Durand (1997, p. 14), o imaginário pode ser compreendido como um “conjunto das imagens e relações de imagens que constitui o capital pensado do homo sapiens”, o estudo dessa complexa rede semântica permite capturar o que se delineia nos pensamentos e sentimentos humanos em qualquer tempo e lugar. É objetivo deste trabalho perscrutar a constelação de imagens que se manifesta na arte literária de José Saramago. O corpus que serve de análise será e A jangada de pedra. Pretendemos investigar a matéria imaginária que organiza esta reconhecida obra a partir dos Estudos do Imaginário na perspectiva interdisciplinar da hermenêutica simbólica, sinalizando configurações de imagens e suas relações com o contexto sóciohistórico e cultural em que se engendram. Distintas marcas históricas singularizam as formas artísticas, as várias releituras e reinvenções de imagens na formulação de apreensões estéticas. Os espaços textuais, ao se retecerem em fluxos operativos, convocam a participação do leitor para compor o diagrama de significações sugerido pelo autor. As reflexões sobre o imaginário assumem abrangência interdisciplinar, possibilitando analisar fenômenos culturais e artísticos de maneira transversalReflexões sobre o imaginário na arte literária de José Saramago: uma leitura interdisciplinar de A jangada de pedra
Keabsahan Hubungan Kerja Antara Perusahaan E-Sports Dengan Atlet E-Sports Dibawah Umur
Authors: Agung I Putu Setya
Published: December 2021

Abstracte-Sports is a new profitable industry at this time. Activists in this field consist of various groups, both adults and children. Underage e-sports athletes are the main target of e-sports companies to use their services in competing. Children who become e-Sports athletes are later called child labor. Author uses a type of juridical normative legal research with a statute approach, conceptual approach, and case studies. The validity of employment agreements and work relationships between child as e-Sports athletes and e-Sports companies must also include the role of the parent or guardian who has authority over the child. A legal work relationship is a work relationship that fulfills the elements of a work relationship, namely orders, jobs and wages. If a work relationship does not fulfill only one element, it cannot be called an work relationship. The work relationship that exists between underage e-sports athletes and e-sports companies is legal.Keywords: E-Sports; Child Labor; Employment Agreement; Work Relationship; Legality.Abstrake-Sports merupakan industri baru yang cukup menjanjikan pada saat ini. Penggiat bidang ini terdiri dari berbagai kalangan, baik orang dewasa hingga anak-anak. Atlet e-Sports dibawah umur menjadi sasaran utama dari perusahaan e-Sports untuk menggunakan jasanya dalam berkompetisi. Anak yang menjadi atlet e-Sports ini lah yang kemudian disebut pekerja anak. Penulis menggunakan tipe penelitian hukum normatif yuridis dengan pendekatan perundang-undangan, pendekatan konseptual, dan studi kasus. Keabsahan perjanjian kerja dan hubungan kerja antara anak dibawah umur sebagai atlet e-Sports dengan perusahaan e-Sports harus turut menyertakan peran orang tua atau wali yang memiliki kuasa atas anak tersebut. Hubungan kerja yang sah adalah hubungan kerja yang memenuhi unsur hubungan kerja yakni perintah, pekerjaan, dan upah. Jika suatu hubungan kerja tidak memenuhi salah satu unsur saja, maka tidak dapat disebut dengan hubungan kerja. Hubungan kerja yang terjalin antara atlet e-Sports dibawah umur dengan perusahaan e-Sports adalah sah.Kata Kunci: E-Sports; Pekerja Anak; Perjanjian Kerja; Hubungan Kerja; Keabsahan.
Pengawasan Dalam Kerja Sama Bank Umum dan Penyelenggara Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi
Authors: Lobo Nabilla Virnanda
Published: December 2021

AbstractPartnership is a collaboration between one party and another, where each party plays its respective roles in a reciprocal relationship that benefits each party. This research will discuss the characteristics of the forms of cooperation between commercial banks and information technology-based lending and borrowing service providers (fintech peer-to-peer lending) and then discusses the supervision of regulatory agencies on cooperation in the financial sector. This research is a doctrinal research using a statute approach and a conceptual approach to obtain a clearer picture. The result of this research is that credit distribution cooperation is carried out by taking into account the provisions regarding information technology-based lending and borrowing services while retail investment sales cooperation and non-performing loan management cooperation are carried out by taking into account the provisions concerning banks and / or commercial banks as in the cooperation. commercial banks. The supervisory authority lies with the Financial Services Authority. Keywords: Fintech P2PL; Commercial Banks; OJK.AbstrakPartnership adalah kerja sama antara satu pihak dengan pihak lainnya dimana masing-masing pihak menjalankan perannya masing-masing dalam hubungan timbal balik yang memberikan keuntungan kepada masing-masing pihak. Dalam penelitian ini akan dibahas mengenai karakteristik bentuk-bentuk kerja sama antara bank umum dengan penyelenggara layanan pinjam meminjam berbasis teknologi informasi (fintech peer-to-peer lending) kemudian membahas mengenai pengawasan lembaga otoritas terhadap kerja sama dalam sektor keuangan tersebut. Penelitian ini merupakan penelitian doctrinal research dengan menggunakan pendekatan perundang-undangan (statute approach) dan pendekatan konseptual (conceptual approach) untuk memperoleh gambaran yang lebih jelas. Hasil dalam penelitian ini yaitu kerja sama penyaluran kredit dilaksanakan dengan memperhatikan ketentuan mengenai layanan pinjam meminjam uang berbasis teknologi informasi sedangkan kerja sama penjualan investasi ritel dan kerja sama pengelolaan non-performing loan dilaksanakan dengan memperhatikan ketentuan mengenai bank dan/atau bank umum sebagaimana dalam kerja sama bank umum. Adapun kewenangan pengawasan berada di Otoritas Jasa Keuangan.Kata Kunci: Fintech P2PL; Bank Umum; OJK.
Legalitas Mobil Auto Pilot Dalam Prespektif Hukum Transportasi di Indonesia
Authors: Nusi Rizal Ramadhani
Published: December 2021

AbstractThe auto pilot car is one of the latest innovations in the world of transportation thanks to technological advancements. With this system the driver no longer needs to control the vehicle as a whole because the control system has been taken by the system. In the operation of all vehicles or modes of transportation, they must comply and not violate the norms in UULLAJ. Including the auto pilot car, the car currently operating and being traded in Indonesia must meet the requirements in UULLAJ and related to the due diligence and type test as stipulated in the Ministry of Transportation Regulation. Is the existence of an auto pilot car on the highway while maintaining the safety of other road users or vice versa? How big is the government's effort in carrying out the mandate of the law to provide a sense of security, comfort for all road users ?. The results of this research show that there are still no regulations that are detailed in detail regarding auto pilot cars and to ensure the safety of road users the government's efforts have not yet appeared in addressing this issue.Keywords: Autopilot Cars; Transportation Law; Legality of Auto Pilot Cars; Government Act.AbstrakMobil auto pilot merupakan salah satu inovasi terbaru di dunia transportasi berkat kemajuan teknologi. Dengan sistem tersebut pengemudi tidak perlu lagi mengendalikan kendaraan secara keseluruhan karena sistem kendali sudah di ambil oleh sistem. Dalam pengoperasian seluruh kendaraan atau moda transportasi wajib sesuai dan tidak melanggar norma yang ada dalam UULLAJ. Termasuk dengan mobil auto pilot, mobil tersebut saat ini beroperasi dan diperjual belikan di Indonesia wajib memenuhi persyaratan yang ada dalam UULLAJ serta terkait uji kelayakan dan uji tipe sebagaimana diatur dalam permenhub. Apakah dengan adanya mobil auto pilot di jalan raya tetap menjaga kemanan pengguna jalan lain atau sebaliknya? Seberapa besar upaya pemerintah dalam menjalankan amanat undang-undangan untuk memberikan rasa aman,nyaman bagi seluruh pengguna jalan raya?. Hasil dari peneilitan ini menunjukan bahwa masih belum ditemukan peraturan yang mengatur secara rinci terkait mobil auto pilot dan untuk menjamin keamanan pengguna jalan raya upaya pemerintah masih belum Nampak dalam menyikapi isu ini.Kata Kunci: Mobil Auto Pilot; Hukum Transpotasi; Legalitas Mobil Auto Pilot; Upaya Pemerintah.
AS LACUNAS DECORRENTES POSITIVISMO JURÍDICO EM UM ESTADO PATERNALISTA COMO UM AGRAVANTE À CRISE DEMOCRÁTICA
Authors: Menezes Caroline Gonçalves de , Aarão Rocha André
Published: December 2021

O presente artigo visa estudar e analisar os efeitos do Estado paternalista e das lacunas oriundas do positivismo jurídico como agravante a crise democrática contemporânea brasileira. Para isso, será demonstrado primeiramente, as nuances e características do Estado Paternalista, bem como a estreita relação deste na implementação dos direitos sociais. A posteriori, será analisado o efeito causado pelas lacunas decorrentes do positivismo jurídico no Estado Paternalista. E por fim, será evidenciado a atual situação da crise democrática brasileira, tal como o quanto os efeitos do Estado Paternalista e o das lacunas legislativas existentes interferem como agravantes dessa crise.
OS LIMITES DO SUPREMO TRIBUNAL FEDERAL COMO LEGISLADOR NEGATIVO
Authors: Santos Elenice Rolemberg , Santos Necéssio Adriano
Published: December 2021

O presente artigo teve como objetivo analisar as limitações impostas ao Supremo Tribunal Federal em decorrência do princípio da separação dos poderes. Além disso, buscou demonstrar a possibilidade da existência de um novo poder para que, consequentemente, a teoria tripartite pudesse ser alterada ou, até mesmo, abolida. Neste sentido, não deve o Supremo Tribunal ter suas atribuições limitadas por um princípio, sendo ele possibilitado de inovar e criar o Direito. Contudo, nota-se a impossibilidade do fim da teoria, visto que foi estabelecida pela Constituição Federal de 1988 como uma cláusula pétrea, isto é, inalterável, não ficando a cargo do Supremo Tribunal Federal inovar ou contestar o que por ela foi estabelecido, sob pena de inconstitucionalidade da decisão. Por fim, para a presente pesquisa, o método utilizado foi o exploratório, baseando-se em livros e dissertações sobre o assunto. Ademais, o trabalho teve como principal motivação a possibilidade de responder se existe ou não um quarto poder e quais os impactos dessa possibilidade para o STF, questionamento realizado em sala no início da academia de Direito.
A INCIDÊNCIA DO CDC AOS PLANOS DE SAÚDE E A VALIDADE DO REAJUSTE DE MENSALIDADE DE PLANO DE SAÚDE INDIVIDUAL OU FAMILIAR FUNDADO NA MUDANÇA DE FAIXA ETÁRIA DO BENEFICIÁRIO.
Authors: Lima Lorrane Tavares , Barbosa Igor de Andrade
Published: December 2021

O presente trabalho tem como objetivo abordar a incidência do CDC aos contratos de planos de saúde e o problema ligado a validade dos reajustes de mensalidade dos planos de saúde ocasionados pela mudança da faixa etária do beneficiário sob a égide do Estatuto do Idoso, da Constituição Federal e, principalmente, do Código de Defesa do Consumidor. Perante esse cenário a pesquisa fixou o seguinte questionamento: Quais são as balizas do Código de Defesa do Consumidor nas relações contratuais envolvendo planos de saúde? Com isso foram estabelecidos como objetivos: Demonstrar o papel do direito do consumidor na proteção dos contratantes de planos de saúde, descrever as consequências da judicialização da saúde suplementar e apresentar um estudo específico sobre a divergência jurisprudencial envolvendo o reajuste de mensalidades nos planos de saúde individual ou familiar em função da mudança de faixa etária do contratante. Para alcançar o desiderato utilizou-se o método descritivo, realizando uma abordagem de natureza qualitativa e o trabalho foi baseado em uma pesquisa bibliográfica. Ao final da pesquisa conclui-se que a aplicação do direito do consumidor nas relações entre as operadoras de planos de saúde e seus consumidores é essencial para o preenchimento das lacunas deixadas pela Lei nº 9.656/1998, bem como há uma necessidade da estruturação de critérios interpretativos sólidos para a tese que trata da validade dos reajustes de mensalidade de plano individual ou familiar fundado na mudança de faixa etária do beneficiário.
ILEGITIMIDADE DO DESCONTO COMPULSÓRIO DA CONTRIBUIÇÃO ASSISTENCIAL NA REMUNERAÇÃO DO FUNCIONÁRIO, SEM PRÉVIA AUTORIZAÇÃO: AFRONTA À CONSTITUIÇÃO
Authors: Silva Valdeis Ribeiro da , Berezowski Maria Leonice S
Published: December 2021

A reforma trabalhista de 2017 foi a mudança mais significativa na legislação trabalhista atual, ocasionando mudanças nas relações empregatícias e na justiça do trabalho. Em destaque a alteração na contribuição sindical que passou a ser opcional, antes era compulsória. Ameaçando a fonte de custeio/financiamento da estrutura e de fortalecimento das entidades sindicais. Despertando-se um déjà vu, visto que a contribuição assistencial, que também era obrigatória e que por décadas esteve cercada de polêmicas sobre a sua legitimidade ou ilegitimidade, quanto à sua cobrança. O fato é que durante anos a fio a contribuição assistencial foi deduzida automaticamente/compulsoriamente dos salários dos trabalhadores, independente de autorização prévia, ou até, mesmo independente de serem filiados ao sindicado, tendo como amparo convenção ou acordo coletivo, que suspostamente cumpriria a redação do artigo 513, alínea “e”, da CLT. A interpretação equivocada do verbo “impor” do dispositivo jurídico citado ocasionou no desconto compulsório da contribuição, erro que permaneceu por décadas, sendo esta injustiça com os trabalhadores corrigida apenas recentemente. Após inúmeras demandas jurídicas, por meio do julgamento do ARE 1018459 em 2017 houve a decretação da inconstitucionalidade do direito de impor contribuições, independe de filiação ao sindicato, por não possuir natureza tributária, sendo assim, a imposição da contribuição assistencial a não associado, ainda que conste em instrumento acordo ou convenção coletiva, fere o princípio da liberdade de associação ao sindicato e também o sistema de proteção ao salário. É salutar informar que à decisão foi atribuída repercussão geral ao tema.

 

PALAVRAS-CHAVE: Contribuição assistencial; compulsória; inconstitucionalidade; liberdade de associação; repercussão geral.
AÇÃO CIVIL EX DELICTO: A INFLUÊNCIA DA AÇÃO PENAL NA DECISÃO DO JUÍZO CÍVEL
Authors: Silva Jonatas dos Santos , Nunes Danilo Henrique , Silva Ana Flávia Rodrigues da
Published: December 2021

Os efeitos da decisão penal no âmbito cível atualmente possuem uma preocupação acadêmica interessante, razão por qual é demonstrada a relevância para estudo e que é feito neste presente trabalho. Isto porque, diariamente diversas pessoas são lesadas e constrangidas, tendo por estas razões violadas a sua integridade, seja física, moral ou financeira. Com o resultado danoso, a responsabilização do agente poderá desdobrar-se em três esferas: a administrativa, a cível e a penal. Neste trabalho, que se abordará os dois últimos temas, parte-se da necessidade de analisar os mecanismos legislativos relacionados a área. Sem contradição e com a análise de diversos autores, o estudo trata de ressaltar a eventual influência penal sobre o feito cível e a consequência de sua aplicação ou não. A respectiva pesquisa guiou-se pelo método dedutivo, buscando contemplar as situações acima apontadas e que são encontradas em livros, artigos científicos e publicações em outros meios acadêmicos, resultando num estudo detalhado do tema, buscando apontar de forma clara os mecanismos que podem serem aplicados em cada caso concreto
UMA ANÁLISE SOBRE A POSSIBILIDADE DA MULHER TRANSEXUAL FIGURAR NO POLO PASSIVO DO CRIME DE HOMICÍDIO QUALIFICADO POR RAZÕES DE SEXO FEMININO
Authors: Mota Fellipe Matheus Guimarães , Feitosa Isabella Sousa , Silva Osnilson Rodrigues
Published: December 2021

O presente trabalho estuda a possibilidade da responsabilização por feminicídio quando a vítima for mulher transexual à luz de princípios constitucionais e penais, como o da dignidade da pessoa humana, e a exclusiva proteção ao bem jurídico. Para tanto, foi realizado uma pesquisa bibliográfica e documental do direito nacional e internacional.  Essa pesquisa está inserida num contexto social brasileiro onde os índices de violência à mulher (cis e trans) são um dos maiores do mundo. Por outro lado, existem correntes de pensamento conservadoras que entendem pela não equiparação da mulher trans à mulher cis nos efeitos jurídicos
AS ORGANIZAÇÕES CRIMINOSAS E A PARTICIPAÇÃO DOS FUNCIONÁRIOS PÚBLICOS.
Authors: da Costa Edgard Gonçalves
Published: December 2021

A coibição da atuação de grupos criminosos sempre foi uma preocupação por parte das nações, dada a inaceitabilidade de certas práticas incondizentes com o Estado democrático. Pela Lei nº 12.850/2013, para que uma organização seja considerada criminosa, entre outros requisitos, deverá contar com a participação de no mínimo quatro pessoas, praticar infrações penais, cujas penas máximas superem a 4 (quatro) anos, ou que sejam de caráter transnacional. A participação de funcionários públicos implica na majoração das penas, visto apresentarem um maior desvalor na concepção do legislador. Metodologicamente, fez-se revisão de literatura, bem como análise da jurisprudência e dos normativos, com abordagem descritiva. Indagou-se quais medidas podem o magistrado adotar quando da apuração da atuação do funcionário público em organização criminosa? O objetivo geral buscou averiguar a exigência da efetiva participação do agente púbico para a prática de infração por tais organizações. Contatou-se o afastamento de aparentes conflitos entre a lei analisada e outros normativos, bem como a necessária atuação do funcionário, que agindo nessa condição, permite à organização criminosa praticar infração penal, majorando-se a pena.
National Health Interview Survey, COVID-19, and Online Data Collection Platforms: Adaptations, Tradeoffs, and New Directions
Authors: Blumberg Stephen J. , Parker Jennifer D. , Moyer Brian C.
Published: December 2021

High-quality data are accurate, relevant, and timely. Large national health surveys have always balanced the implementation of these quality dimensions to meet the needs of diverse users.

The COVID-19 pandemic shifted these balances, with both disrupted survey operations and a critical need for relevant and timely health data for decision-making. The National Health Interview Survey (NHIS) responded to these challenges with several operational changes to continue production in 2020. However, data files from the 2020 NHIS were not expected to be publicly available until fall 2021. To fill the gap, the National Center for Health Statistics (NCHS) turned to 2 online data collection platforms—the Census Bureau’s Household Pulse Survey (HPS) and the NCHS Research and Development Survey (RANDS)—to collect COVID-19‒related data more quickly.

This article describes the adaptations of NHIS and the use of HPS and RANDS during the pandemic in the context of the recently released Framework for Data Quality from the Federal Committee on Statistical Methodology. (Am J Public Health. 2021;111(12):2167–2175. https://doi.org/10.2105/AJPH.2021.306516 )
Preoperative Nutritional Status and Risk Factors Associated with Delayed Discharge in Geriatric Patients Undergoing Gastrectomy: A Single-Center Retrospective Study
Authors: Zhao Xining , Liu Jie , Wang Ying , Yang Yuying , Pan Yan , Ge Shengjin
Published: December 2021

Background
Preoperative malnutrition is an independent risk factor for postoperative complications and survival for gastric cancer (GC) patients. This study aimed to investigate the prevalence of malnutrition and the risk factors associated with the delayed discharge of geriatric patients undergoing gastrectomy.
Material and Methods
A retrospective study of GC patients (age ≥ 65) who underwent gastrectomy at Zhongshan Hospital from January 2018 to May 2020 was conducted. Clinical data, including demographic information, medical history, surgery-related factors, and perioperative nutritional management were collected and analyzed.
Results
A total of 783 patients were reviewed. The overall frequency of malnutrition was 31.3% (249/783). The levels of albumin, prealbumin, and hemoglobin were lower in the malnutrition group compared with the well-nourished group. Moreover, 51 (6.5%) patients received preoperative total parenteral nutritional support. All patients received postoperative parenteral nutrition; 194 (77.9%) patients in the malnutrition group received an infusion of carbohydrates with composite amino acid and 55 (22.1%) received total nutrient admixture. No significant difference was found in the duration of postoperative nutrition between the groups (P>0.05). The malnutrition group was associated with a higher rate of surgical site infections (SSIs) (P<0.001). Multivariate cox regression revealed that age >70 years, length of surgery >180 min, and postoperative complications were significant risk factors associated with delayed discharge.
Conclusion
Malnutrition is relatively common in elderly patients undergoing gastrectomy. Age, length of surgery, and postoperative complications are important risk factors associated with delayed discharge. Elderly GC patients with risk factors urgently require specific attention to shorten hospital stays.
Adsorption Performance of Human-like Collagen by Alkali-modified Kapok Fiber: A Kinetic, Equilibrium, and Mechanistic Investigation
Authors: Cao Liyao , Wang Hongchang , Shen Hua , Wang ruiliu , Wang Fumei , Xu Guangbiao
Published: December 2021

Collagen-based dressings achieve excellent repair of the skin during metical cosmetology, which has received a lot of attention recently. Although great progress has been made on using biomass fiber as dressing carrier, more research is required on developing novel biomass fibers because of the limitations of (i.e., high cost and complex processing) of existing materials. In this study, the adsorption behaviors of two human-like collagen were studied by examining the Kapok fiber that was modified using alkali consisting of various amounts of the mass fraction. Results show that the alkali-modified Kapok fiber surface becomes rough with vertically arranged grooves, and the cross-section depicts the hollow cavity structure. The composition analysis of alkali modified Kapok shows that alkali dissolves part of the hemicellulose and lignin. Additionally, the surface energy rises sharply and the water contact angle changed from hydrophobic to hydrophilic. The adsorption amount of raw Kapok fiber is around 0.6g/g, which accounts for only one twenty-first of the adsorption amount of alkali-treated Kapok (around 12.6g/g), while the equilibrium adsorption amount was not sensitive to alkali concentration. The kinetics of human-like collagen followed both Quasi first and Quasi second order kinetic model, implying that the adsorption process where characterized by both physisorption and chemisorption. Finally, characterization of the AKF-2 coupled with the studies based on the inter-particle diffusion model showed a three-step of human-like collagen diffusion consisting of surface diffusion, inter-fiber diffusion and fiber' hollow cavity diffusion. Our results demonstrate a perfect high absorption performance of Kapok fiber providing a potential for application of collagen-base dressings.
Deep Learning-Based Beamforming for Millimeter-Wave Systems Using Parametric ReLU Activation Function
Authors: Hamdy Alshimaa , Soliman Tarek Abed , Rihan Mohamed , Dessouky Moawad I.
Published: December 2021

Beamforming design is a crucial stage in millimeter-wave systems with massive antenna arrays. We propose a deep learning network for the design of the precoder and combiner in hybrid architectures. The proposed network employs a parametric rectified linear unit (PReLU) activation function which improves model accuracy with almost no complexity cost compared to other functions. The proposed network accepts practical channel estimation input and can be trained to enhance spectral efficiency considering the hardware limitation of the hybrid design. Simulation shows that the proposed network achieves small performance improvement when compared to the same network with the ReLU activation function.
Development and Evaluation of the Effectiveness of the Web-Based Education Program Among Cancer Patients Undergoing Treatment of Systemic Chemotherapy: A Randomised Controlled Trial
Authors: Bektas Hicran , Coskun Hasan Senol , Arikan Fatma , Ozcan Keziban , Tekeli Aysel , Kondak Yasemin , Sezgin Merve Gozde , Yangec Elcin , Kalav Simge
Published: December 2021

Purpose
This study aims to develop a web-based education program among cancer patients undergoing treatment of systemic chemotherapy and to evaluate the effect of the program on symptom control, quality of life, self-efficacy, and depression.
Methods
A web-based education program was prepared in line with patient needs, evidence-based guidelines, and expert opinions and tested with 10 cancer patients. A single-blind, randomised controlled study design was applied at a medical oncology unit of a university hospital. Pretests were applied to 60 cancer patients undergoing systemic chemotherapy, and the patients (intervention:30, control: 30) were randomized. The intervention group used the web-based education program for three months, and they were allowed to communicate with researchers 24/7 via the website. The effectiveness of the web-based education program at baseline and after 12 weeks was evaluated. The CONSORT 2010 guideline was performed.
Results
Expert opinions were found to be compatible with each other (Kendall's Wa = 0.233, p=0.008). The difference between symptom control (p=0.026) and quality of life (p=0.001) during the three-month follow-up of the groups were statistically significant, and there was no difference between the groups in terms of self-efficacy and depression levels (p˃0.05).
Conclusion
The web-based education program was found to be effective in remote symptom management and improving the quality of life of cancer patients.
Trial registration
www.clinicaltrials.gov , NCT05076916 (12 October 2021, retrospectively registered)
Infrastructures Development, Environmental Quality And Economic Growth In Nigeria
Authors: Ojo Ademola , Amassoma Ditimi J.
Published: December 2021

The earth as a planet supports human life, living and activities that attract extensive and intensive socioeconomic influences on the environment and the economy. Such activities like Infrastructures development exert increasing and divers environmental quality concerns and hence on economic growth. While these variables appear interrelated due to many factors including population growth, urbanization, industrialization etc., however, the nature of the interrelationship is not largely known especially in Nigeria. This study therefore investigated and examine their relationship using time series data between 1990-2019 by adopting Co-Integration estimation technique through the Bound Test approach of Auto Regressive Distributive Lag (ARDL) method, using percentage share of Building and Construction Sector (BCS) of GDP, Carbon dioxide percentage of fuel combustion (CTE), annual growth rate of Agriculture (AFF), population growth, GDP growth rate etc. as variables. The study revealed that infrastructures development, environmental quality explains economic growth and they all have both short and long run relationship while specifically population growth and AFF variables are positively significant to economic growth. The finding evidences the significance of the relationship and consequently recommended new roles for infrastructure sets and production processes that consider environmental quality mindsets to achieve positive green economic growth outcomes in Nigeria.JEL Classification: Q5, O18, O44
CircCASC15-miR-100-mTOR may Influence the Cervical Cancer Radioresistance
Authors: Yao Tingting , Chen Zhiliao , Peng Yongpai , Zhong Guanglei , Huang Chunxian , Li Jing(F) , Li Ruixin
Published: December 2021

Background

Cervical cancer has ranked the top one in gynecological malignancies for incidence. Radioresistance is now becoming a leading reason of recurrence.
Methods

Our microRNA array data indicated that the miRNA-100 level decreased significantly during radioresistance. In this study, we up-regulated miR-100 in Hela and Siha cells by using miR-100 mimics and observed apoptosis, proliferation, cell cycle and invasion.
Results

It turned out that with overexpression of miR-100, the cells had more apoptosis and less invasiveness as well as proliferation. It may also influence cell cycle via target gene mTOR, and it deed reduced EMT. To examine the role of miR-100 in radioresistance, there was no significant result showed by BSP.While the circCASC15 has been identified with sponge function according to RNA pull down and ISH.
Conclusion

The conclusions indicate miR-100 is a tumor suppressor gene and could be a therapeutic target in radio-resistant cervical cancers.
Risk Factors for Opioid-induced Constipation in Cancer Patients: a Single-institution, Retrospective Analysis
Authors: Kanbayashi Yuko , Ishizuka Yuichi , Shimizu Mayumi , Sawa Shohei , Yabe Katsushige , Uchida Mayako
Published: December 2021

Purpose: To identify risk factors for opioid-induced constipation (OIC).Methods: This study retrospectively analysed 175 advanced cancer patients who were receiving pain treatment with opioids and were newly prescribed laxatives for OIC at Seirei Hamamatsu General Hospital between November 2016 and June 2021. For the regression analysis of factors associated with OIC, variables were extracted manually from medical charts. The effect of laxatives was evaluated 3 days after administration. The effect of laxatives was evaluated based on whether the OIC was improved. The OIC was defined based on Rome IV diagnostic criteria. Multivariate ordered logistic regression analysis was performed to identify risk factors for OIC. Optimal cut-off thresholds were determined using receiver operating characteristic analysis. Values of P < 0.05 (two-tailed) were considered significant. Results: Significant factors identified included body mass index (BMI) (odds ratio [OR] = 0.141, 95% confidence interval [CI] = 0.027–0.733; P = 0.020), chemotherapy with taxane within 1 month of evaluation of laxative effect (OR = 0.255, 95%CI = 0.068–0.958; P = 0.043), use of naldemedine (OR = 2.791, 95%CI = 1.220–6.385; P = 0.015) and addition or switching due to insufficient prior laxatives (OR = 0.339, 95%CI = 0.143–0.800; P = 0.014).Conclusion: High BMI, chemotherapy including a taxane within 1 month of evaluation of laxative effect, no use of naldemedine and addition or switching due to insufficient prior laxatives were identified as risk factors for OIC in advanced cancer patients with cancer pain.
Assessing the Influence of Inter Tropical Discontinuity on Total Column Ozone Variation Over West Africa
Authors: Arowolo Ayomide Victor , Oluleye Ayodeji
Published: December 2021

The focus of this study is to evaluate the influence of Intertropical Discontinuity (ITD) on the variation of Total column ozone (TCO). Relevant information is supplied on the temporal and spatial variability of TCO along the ITD zone, which is an important factor influencing the earth's atmosphere. Several studies over the years have established the relationship and influence several atmospheric processes have on TCO. However, the relationship between Intertropical discontinuity and TCO over West Africa has a gap. This study tends to examine the influence ITD has on TCO variation using the West Africa region as a case study. The study used Wind, ozone and dewpoint temperature data for the period between 1980-2019. To assess the variability and trend over the study region, several statistical methods were used, including Pearson correlation, Mann-Kendall, and linear regression model. The Mann-Kendall test shows an increasing trend throughout the months over the study region. Spatial analysis also revealed that regions North of the ITD has a higher concentration of TCO that the southern region of the ITD. however, ITD influence was more visible during the wet month of June to August (JJA) as the highest concentration of TCO was observed during this period across all latitude but more deviation was observed between latitude 100N to 180N, while the least occurrence is observed when ITD is at its minimum position in the month of December to February (DJF). The ACRV shows that 140N exhibit the highest variation with a value of 4.84, while the deviation is also at its highest with value of 13.65. The monthly position of ITD for Forty years was also analysed to observe the monthly deviation along the ITD region forty years and the spatial distribution of TCO was analysed from January to December. It’s of note that during the cause of this study, ozone hole which is designated by concentration less than or equal to 220DU was not recorded. The highest and the lowest value of TCO is 295DU and 227DU respectively with an average range of 68DU.
Repeatability and Learning Effect in the 6MWT in Preoperative Cancer Patients Undergoing a Prehabilitation Program
Authors: Sebio-García Raquel , Dana Fernando , Gimeno-Santos Elena , López-Baamonde Manuel , Ubré Marta , Montané-Muntané Mar , Risco Raquel , Messagi-Sartor Monique , Roca Josep , Martínez-Pallí Graciela
Published: December 2021

Objective
the main objective was to assess repeatability and learning effect of the six-minute walk test (6MWT) in a cohort of preoperative cancer patients referred to a prehabilitation program. As a secondary objective we aimed to identify determinants of improvement in the second test.
Materials and Methods
secondary analysis from a large prospective study on the implementation of a multimodal prehabilitation program in a real-life scenario. Eligible patients were assessed at baseline before starting the prehabilitation program. The 6MWT was conducted according to the American Thoracic Society (ATS)/ European Respiratory Society (ERS) guidelines with two tests being performed under identical conditions separated by 30 minutes. The distance covered (in meters) and the physiological responses (heart rate, oxygen saturation, fatigue and dyspnea) to each test were recorded and compared.
Results
170 patients (60.9%) were analyzed. Repeatability of the distance covered with the 6MWT was excellent (ICC = 0.98; 95% CI: 0.92 – 0.99), but a mean increase of +19.5 meters (95% CI: 15.6 - 23.5m; p=<.001) in the second test was found, showing a learning effect with limits of agreement between -31.3 and 70.4m. Coefficient of variation was 4%. No clinical factor was found to be associated with an improvement in the second test.
Conclusions
the 6MWT showed excellent repeatability in preoperative cancer patients, but a significant learning effect is present. No associated factors with a clinically meaningful improvement in the second test were identified. In light of these findings, two attempts of the 6MWT should be encouraged in this population.
Applications of Spectroscopic Techniques for Polymer Nanocomposite Characterization
Authors: BATOOL MARYAM , Haider Muhammad Nouman , Javed Tariq
Published: December 2021

During past decades, spectroscopic techniques find wide range of applications ranging from biological applications to the measurement of chemical composition and characterization of variety of substances i.e., polymers, nanocomposites etc. Nanocomposites are emerging and growing materials having wide variety of uses. To study the characteristic properties, characterize, and development of new materials using polymer nanocomposites, several molecular characterization techniques are available and are in use today. Principle objective of this review is to summarize the knowledge in current characterization techniques and to study the applications of fluorescence, solid-state nuclear magnetic resonance (NMR), infrared, besides Raman molecular characterization techniques for characterization of polymers, filler, and composites. Fluorescence technique did not provide detailed analysis of materials while solid-state NMR spectroscopy determine silanol hydroxyl groups at the silica exterior in addition to their interactions with polymer and polymer-filler interfacial interactions (via relaxation time). For characterization of various kinds of functional groups in polymer/ fillers, infrared spectroscopy employed. While Raman spectroscopy finds extensive applications for analysis of carbon-based materials. Novelty of this review is that till yet very few review papers have been published which briefly describe all these mentioned techniques along their applications in a very simple and an effective way.
Solanesol Mediated SIRT-1 Activation Prevents Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder in Rats
Authors: Rajkhowa Bidisha , Mehan Sidharth , Sethi Pranshul , Bhalla Sonalika , Prajapati Aradhana , Kumar Sumit , Alshammari Abdulrahman , Alharbi Metab , AlSuhaymi Naif , Alghamdi Abdullah , Alqahtani Abdulsalam A. , Almoshari Yosif
Published: December 2021

Background
Bipolar disorder (BD) is a chronic mental illness characterized by mood fluctuations that range from depressive lows to manic highs. Several studies have linked the downregulation of SIRT-1 (silent mating type information regulation-2 homologs) signaling to the onset of BD and other neurological dysfunctions. The purpose of this research was to look into the neuroprotective potential of Solanesol (SNL) in rats given ICV-Ouabain injections, with a focus on its effect on SIRT-1 signaling activation in the brain. Ouabain, which is found in hypothalamic and medullary neurons, is an endogenous inhibitor of brain Na+/K+ ATPase. The inhibition of brain Na+/K+ ATPase by Ouabain may also result in changes in neurotransmission within the central nervous system. SNL is a Solanaceae family active phytoconstituent produced from the plant Nicotiana tabacum. SNL is used as a precursor for the production of CoQ10 (Coenzyme Q10), a powerful antioxidant and neuroprotective compound. In the current study, lithium (Li), an important mood stabilizer drug, was used as a control.
Methods
This study looked at the neuroprotective potential of SNL at dosages of 40 and 80 mg/kg in ICV-OUA injections that caused BD-like neurobehavioral and neurochemical defects in Wistar rats. Wistar rats were placed into eight groups (n=6) and administered 1 mM/0.5µl ICV-OUA injections for three days. Neurochemical assessments were done in rat brain homogenates, CSF, and blood plasma samples at the end of the experiment protocol schedule.
Results
Long-term SNL and lithium administration have been shown to decrease the number of rearing and crossings, as well as reduce time spent in the center, locomotor activities, and immobility time. Solansesol treatment gradually raises the amount of Na+/K+ ATPase, limiting the severity of behavioural symptoms. These findings also revealed that SNL increases the levels of SIRT-1 in CSF, blood plasma, and brain homogenate samples. Furthermore, in rat brain homogenates and blood plasma samples, SNL modulates apoptotic markers such as Caspase-3, Bax (pro-apoptotic), and Bcl-2 (anti-apoptotic). Mitochondrial-ETC complex enzymes, including complex-I, II, IV, V, and CoQ10, were also restored following long-term SNL treatment. Furthermore, SNL lowered inflammatory cytokines (TNF-α, IL-1β) levels while restoring neurotransmitter levels (serotonin, dopamine, glutamate, and acetylcholine) and decreasing oxidative stress markers.
Conclusion
As a result, our findings suggest that SNL, as a SIRT-1 signalling activator, may be a promising therapeutic approach for BD-like neurological dysfunctions.
WITHDRAWN: Optimal Licensing Strategy of Green Technology With Corporate Social Responsibility (CSR)
Authors: Li Dongdong , Shang Chenxuan
Published: December 2021

This paper develops a duopoly model to investigate a firm’s green technology licensing strategy with corporate social responsibility (CSR). In our model, licensing is conducted by an inside innovator and the patent holder may take CSR activities under a time-consistent emission tax. The result shows that fixed-fee licensing is always the optimal strategy of the patent holder when there is no CSR. In the CSR case, when the reduction degree of abatement cost coefficient is large, the optimal licensing strategy of the patent holder changes from pure royalty licensing to fixed-fee licensing as the degree of CSR decreases. Furthermore, we find that neither conflict nor consistency always exists between social welfare and firm payoff goals. When the degree of CSR is relatively low, fixed-fee licensing is preferred both by the patent holder and the government. Otherwise, when the degree of CSR is relatively high, the government prefers fixed-fee licensing, while the patent holder prefers royalty licensing. Finally, we analyze the effects of CSR behaviors on environment and social welfare. We show that CSR is beneficial for environment, while it is not always beneficial for social welfare.JEL Classifications: D42; M14; I13
Assessment of The Dioxins Leaching Potentials In Selected Soils Through Breakthrough Curves (BTCs) Model
Authors: Gul Nida , Khan Bushra , Kakakhel Ishaq Ahmad Mian , Shah Syed Muhammad Mukarram , Saeed Muhammad , Ali Fayaz
Published: December 2021

The current study was to investigate the leaching and groundwater contamination potential of selected Dioxins, in local soil series. Solute transport was modelled through Breakthrough curve (BTC) plots, based on distribution coefficient (Kd), Retardation factor and Dispersivity, under normal velocity (20 cm day -1) and preferential or steady flow (50 cm day -1). In case of Dibenzo -p- Dioxin (DD), distribution coefficient values were found in order of Charsadda > Peshawar > Sultanpur series, while for 2 Chloro- p- Dioxin (2Cl-DD), the order was Charsadda > Sultanpur > Peshawar. However, the overall sorption was low. Under the normal velocity both of selected Dioxins (DD & 2Cl-DD), BTC plots relatively took longer time to reach the point of saturation as compared to high seepage velocity. However, the overall solute transport was found to be rapid. This behaviour showed that sorption of the Dioxins selected soil series is low and there is potential for leaching and groundwater contamination.
High-Resolution Computed Tomography Based Comparative Analysis of Asbestosis vs. Fibrotic Hypersensitivity Pneumonitis
Authors: Ma Ruimin , Li Shuang , Wang Yuanying , Yang Shuqiao , Bao Na , Ye Qiao
Published: December 2021

BackgroundAsbestosis and fibrotic hypersensitivity pneumonitis (FHP) are fibrotic interstitial lung diseases that develop secondary to inhalation exposure. The differential diagnosis is based on clinical evaluation of imaging findings, particularly in developing countries. We compared the imaging features between asbestosis and FHP to gain a better understanding of the differential diagnostic value of these conditions.MethodsThis comparative study included 204 patients with asbestosis and 74 patients with FHP. We compared patients’ clinical data and chest high-resolution computed tomography (HRCT) images obtained from a predesigned chart. The International Classification of HRCT for Occupational and Environmental Respiratory Diseases was used to categorize chest imaging findings in patients. Diagnostic tests were used to compare the imaging features of asbestosis and FHP.ResultsPatients with asbestosis were older and had a longer latent period until disease manifestation than those with FHP. Asbestosis was characterized by irregular and/or linear opacities, with lower lung preponderance, accompanied by ground-glass opacities and mosaic attenuation. Notably, 98.5% of patients with asbestosis showed benign pleural abnormalities, and >33% of these patients had diffuse pleural thickening with parenchymal bands and/or rounded atelectasis. Abnormalities of the mediastinal and diaphragmatic pleura were observed only in cases of asbestosis, and this finding showed high specificity for the diagnosis for asbestosis compared with that for FHP. Subpleural dots or diaphragmatic pleural abnormalities showed moderate sensitivity and high specificity for diagnosis of asbestosis compared with that for FHP. Interobserver reliability was good for evaluation of imaging findings including honeycombing, pleural calcification, lymphadenectasis, and lymph node calcification.ConclusionsHRCT-based imaging findings can distinguish between asbestosis and FHP to a certain extent, particularly with regard to subpleural dots and diaphragmatic pleural abnormalities that characterize the former.