bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro antiviral activity of VIFERON® rectal suppositories against SARS-CoV-2
Authors: Isakova-Sivak I. N. , Stepanova E. A. , Rudenko L. G. , Bartov M. S. , Vyzhlova E. N. , Malinovskaya V. V.
Published: March 2022

In 2020–2021, the world was engulfed by the pandemic of a new coronavirus infection (COVID-19) caused by the SARS-CoV-2 virus. The low population coverage with vaccination against COVID-19 and the lack of herd immunity result in the need to find an effective and safe etiotropic treatment. Medicinal agents for treatment of COVID-19, approved while preparing this publication, have several limitations related to the conditions of their use and/or population category. In this situation, interferon-containing drugs widely used in Russia and the CIS for prevention and treatment of viral infectious diseases, i.e. ARVI and influenza, may hold promise. This study aims to confirm in vitro antiviral activity against SARS-CoV-2 for the preparation VIFERON® containing recombinant human interferon alpha-2b (IFNα-2b). Materials and methods. Vero CCL-81 cells were infected with hCoV-19/StPetersburg-RII3524VR4/2020 strain of SARS-CoV-2 at doses of 10 TCID50 or 100 TCID50 per well. The suppressive effect of IFN-2b, extracted from VIFERON® in dosage form of rectal suppositories, was evaluated by qRT-PCR at 24 h and 48 h after the infection of cells in two schemes, simulating preventive (24 h before infection) and therapeutic (2 h after infection) use of drugs. Results. IFNα-2b at concentrations of 800, 400, 200, 100 and 50 IU/ml, extracted from rectal suppositories of VIFERON®, showed high biological activity, displayed as inhibition of SARS-CoV-2 strain replication in both infectious doses evaluated either at 24 h or at 48 h after cell infection. The “preventive” vs. “therapeutic” scheme was found to be more effective. In the “preventive” scheme the virus titre decreased by more than 3 lg TCID50 at 24 hours post-infection and by 5–6 lg TCID50 at 48 hours post-infection after administration of 800 IU/ml IFNα-2b. Conclusion. The study results evidence that VIFERON® in dosage form of rectal suppositories may be promising for prevention and treatment of new coronavirus infection in clinical practice.
Forming a Positive Image of an Employee of Penitentiary System in the Media (on the Example of Working of the Press Service of the Penitentiary System of Russian Federation in Sverdlovsk Region)
Authors:   Federal Penitentiary Service of Russia in the Sverdlovsk Region, Tatarenkova Dina S.
Published: March 2022

The article provides an overview of studies on the image of law enforcement officers, including the penitentiary system in the media. On the example of the activities of the press service of the Penitentiary system of Russia in the Sverdlovsk region, the ways of forming a positive image of an employee of the penitentiary system are considered. The method of content analysis of materials on the activities of the penal enforcement system for 2020 was used, which allowed us to conclude that at this stage the interest of journalists in preparing materials on the activities of the penal enforcement system is shifted to the topic of convicts, not employees. And the positive materials that are prepared and distributed by the press service of the Penitentiary system of Russia in the Sverdlovsk region, due to a number of factors, are not enough to form a positive image of an employee of the penal system.
The Novels of D. Tartt in the Context of the phenomenon of “Young Adult Literature”: Poetics and References to F. M. Dostoevsky
Authors:   Krasnoyarsk State Pedagogical University after V. P. Astafiev, Shalimova Nadezhda S.
Published: March 2022

This article is centered on the work of the modern American writer D. Tartt. The genre and narrative constitutions of young adult literature are highlighted in her novels, which are described in the context of relying on the poetics of F. M. Dostoevsky’s novels. The article reconstructs mythological and symbolic models and images in the works of D. Tartt and F. M. Dostoevsky, as well as genetic and typological connections, both in genre and in the plot structures of the novels “The Goldfinch” and “The Idiot”.
The Museification of the Former Prisons: International Experience and Russian Reality
Authors:   Omsk State Technical University, Slivkova Yulia V.
Published: March 2022

This article is dedicated to several modern approaches to the cultural museification process of former prisons. “The fate” of closed and no longer working prisons is the subject of discussion between state authorities, business and civilian population. The result of the prison transformation directly depends on the funding sources. Currently, there are multiple examples of prison buildings being used as cinema settings, social housing, hotels and hostels, and shopping centers. Recently, visiting old prisons has become a popular destination for cultural and educational tourism, so the problem of creating museums on their territory has attracted fixed scientific attention. The research on the museification process of prison facilities involves the study of the processes of repurposing former places of detention; studying the features of excursion organizing and analyzing the impressions of prison museum visitors. This article analyzes and emphasizes Canadian and French cultural experiences of prison museification, including their strategies of museification and tour guides classification. As an example of the implementation of a comprehensive approach to the preservation of liberty deprivation places as the objects of cultural heritage, the French Virtual Museum of Justice, whose exposition is constantly being updated, is considered. Prisons that have been turned into Museums are multi­faceted objects, and the goals of preserving and exploring these heritage sites also vary: from studying architectural specific of the building to perpetuating the memory of the innocent.
Media Ecology as a Cultural Problem and a Task of Education: Axiological Aspect
Authors:   Educational Strategies Institute, Murzina Irina Ya.
Published: March 2022

The article analyzes the phenomenon of media ecology in the context of culture and educational objectives. The issues of media ecology are revealed on the basis of an interdisciplinary methodology and taking into account the analysis of the socio­cultural realities of recent times (post­truth, infodemia, the formation of an information­media linguistic personality). The author identifies the three most significant aspects of media ecology for the current state of media culture — ethical, communicative and educational — and reveals their specifics. Special attention is paid to media education, defined as an ecological and aesthetic type of educational practice. It is concluded that with the development of digitalization and mediatization, axiological aspects of media ecology will be especially relevant, since they relate to the existence of a person in the world of culture.
Tendência temporal das notificações de lesão autoprovocada em adolescentes no ambiente escolar, Brasil, 2011-2018
Authors: Aragão Conceição de Maria Castro de , Mascarenhas Márcio Dênis Medeiros
Published: March 2022

Resumo Objetivo: Analisar a tendência de notificações de lesão autoprovocada entre adolescentes no ambiente escolar, Brasil, 2011 a 2018. Métodos: Estudo ecológico de série temporal, sobre dados do Sistema de Informação de Agravos de Notificação, utilizando-se o modelo de regressão linear de Prais-Winsten. Resultados: Um total de 1.989 casos foram notificados. As taxas de notificação variaram de 0,09 a 2,75/100 mil habitantes, com tendência crescente, tanto no sexo feminino (VPA = 66,0%; IC95% 39,0;98,3) como no masculino (VPA = 55,2%; IC95% 29,9;85,4). A região Norte apresentou tendência estacionária, enquanto as regiões Sudeste e Sul apresentaram tendência crescente, destacando-se o Rio de Janeiro (VPA = 85,5%; IC95% 58,0;117,8) e o Paraná (VPA = 73,6%; IC95% 41,9;112,3). Na região Centro-Oeste, apenas o estado de Mato Grosso do Sul apresentou incremento (VPA = 54,5%; IC95% 16,9;104,2). Conclusão: Verificou-se tendência crescente nas notificações de lesão autoprovocada em adolescentes no ambiente escolar no Brasil, no período estudado.
Advanced in situ and laboratory characterisation of the ALPACA chalk research site
Authors: Vinck Ken , Liu Tingfa , Jardine Richard J. , Kontoe Stavroula , Ahmadi-Naghadeh Reza , Buckley Róisín M. , Byrne Byron W. , Lawrence James A. , Mcadam Ross A. , Schranz Fabian
Published: March 2022

Low- to medium-density chalk at St Nicholas at Wade, UK, is characterised by intensive testing to inform the interpretation of axial and lateral tests on driven piles. The chalk destructures when taken to large strains, especially under dynamic loading, leading to remarkably high pore pressures beneath penetrating cone penetration testing and driven pile tips, weak putty annuli around their shafts and degraded responses in full-displacement pressure-meter tests. Laboratory tests on carefully formed specimens explore the chalk's unstable structure and markedly time- and rate-dependent mechanical behaviour. A clear hierarchy is found between profiles of peak strength with depth of Brazilian tension, drained and undrained triaxial and direct simple shear tests conducted from in situ stress conditions. Highly instrumented triaxial tests reveal the chalk's unusual effective stress paths, markedly brittle failure behaviour from small strains and the effects of consolidating to higher than in situ stresses. The chalk's mainly sub-vertical jointing and micro-fissuring lead to properties depending on specimen scale, with in situ mass stiffnesses falling significantly below high-quality laboratory measurements and vertical Young's moduli exceeding horizontal stiffnesses. While compressive strength and stiffness appear relatively insensitive to effective stress levels, consolidation to higher pressures closes micro-fissures, increases stiffness and reduces anisotropy.
CLINICAL AND DEMOGRAPHIC EVALUATION OF PATIENTS ADMITTED TO THE PEDIATRIC INTENSIVE CARE UNIT
Authors: PERK Oktay
Published: March 2022

Purpose: This study aimed to evaluate the patients who received health services in the pediatric intensive care unit (PICU) of Ankara City Hospital’s Pediatrics Department in a 2-year period and the outcomes of these cases by examining their clinical and demographic characteristics.

Materials and Methods: This retrospective study was carried out in the 32-bed tertiary PICU of Ankara City Hospital. The records of 2280 patients between the ages of 1 month and 18 years who were hospitalized in the PICU between September 1, 2019, and September 1, 2021, were retrospectively analyzed. Age, sex, presence of chronic disease, reason for hospitalization in the intensive care unit, length of stay, status and duration of respiratory support, and mortality rates were evaluated.

Results: The mean age of the patients was 5.16±5.12 years and the mean PICU stay was 12.47±20.16 days. Bronchiolitis, sepsis, pneumonia, trauma, congenital heart disease, status epilepticus, hematological diseases, oncological diseases, diabetic ketoacidosis, and metabolic diseases were found to be the most common reasons for hospitalization in the PICU. The most frequent underlying diseases were neurological, respiratory, hematological, cardiological, endocrinological, nephrological, gastrointestinal system, oncological, and metabolic diseases. The mortality rate of these patients was 10.8%. Underlying oncological or hematological diseases and immunodeficiency, higher susceptibility to infection, longer hospital stay, and longer duration of mechanical ventilation were found to be statistically significantly higher in deceased patients compared to survivors.

Conclusion: The profile of patients admitted to PICUs is expanding day by day. A significant decrease in mortality was observed in all patient groups as a multidisciplinary approach was implemented. It was also observed that most of the patients had an underlying chronic disease and this condition was associated with mortality.
Retrospective Analysis of Hepatitis B and Hepatitis C Viruses and HIV Infections in Patients Presenting to the General Surgery Clinic and Evaluated Preoperatively
Authors: DURAN Ali
Published: March 2022

Aim: Hepatitis B(HBV), Hepatitis C(HCV) and HIV infections are important parenterally transmitted infections. The aim of this study is to determine the seroprevalence of HBsAg, anti-HBs, anti-HCV and anti-HIV in patients with preoperative preparation.

Materials and MethodS: Anti-HBs, HBsAg, anti-HCV, anti-HIV tests with chemiluminescent enzyme immune-assay method in a total of 900 patients applied to the General Surgery Clinic and were evaluated preoperatively by Abbott Architect i1000 immunoassay analyzer (Abbott Diagnostics, Illinois, USA) operated according to the manufacturer's instructions. Anti-HBs titer above 10 IU/mL, serum optical density/”cut-off” control optical density (S/Co) ≥1 in HBsAg, anti HCV and anti-HIV tests were accepted as positive. HBV-DNA and HCV RNA tests were performed with real-time PCR method.

Results: Anti-HBs test was found to be reactive in 34.11% and nonreactive in 65.89%. HBsAg positivity was 1.0% (9/900), and anti-HCV positivity was 0.33% (3/900). Anti-HIV positivity and HBsAg-anti-HCV association were not detected. Six patients with HBsAg positivity and one patient with anti-HCV positivity were found incidentally during preoperative examinations.

Conclusion:As a result of these data, it can be concluded that cost-effective serological tests for HBV and HCV infections performed in the preoperative period are extremely important in the detection of asymptomatic patients. Preoperative screening is important in terms of early diagnosis of patients before complications such as cirrhosis and HCC develop, enabling treatment, as well as enabling healthcare professionals to increase infection control measures while intervening with infected patients, to be more careful in terms of percutaneous injuries, and to reduce the risk of transmission.
Creación de valor como instrumento de productividad bajo sostenibilidad en cooperativas especializadas sin sección de ahorro en Bogotá
Authors: Rodríguez Alvarado Gloria Asceneth
Published: March 2022

Resumen

Este artículo tiene como objetivo explicar cómo 12 cooperativas especializadas sin sección de ahorro en Bogotá crean valor en términos de productividad bajo sostenibilidad, por medio del análisis de indicadores de continuidad, de base social, de eficacia, de eficiencia, solvencia y endeudamiento entre 2015 y 2019.  Para esta investigación se utilizó una base de datos de la Superintendencia de Economía Solidaria con información financiera. El enfoque de carácter mixto, permitió analizar los resultados de los indicadores y formular una propuesta direccionada a la creación de valor bajo los principios del cooperativismo. Como resultado, se observó que las cooperativas objeto de estudio presentan consistencia y robustez en su desempeño.  Po último, con este estudio se concluyó que las situaciones favorables pueden potencializarse mediante el análisis de su ejercicio plasmado en los estados financieros.
Space Versus Time: Flattening History. An Architectural History Perspective
Authors: Popescu Carmen
Published: March 2022

From its very beginning, architectural historiography tended to ‘flatten’ historicity in favor of a ‘spatialized’ discourse. This process was triggered by gradually emphasizing space over time, as becomes clear in examining this longue durée, from the ‘barbarian’ architectures of Quatremère de Quincy and Seroux d’Agincourt to the ‘non-historical styles’ of Banister Fletcher, and from turning peripheries into productive territories of architectural resistance in the theories on critical regionalism to shaping a global history of architecture. The focus on space changed the dynamics of the narrative from a vertical construction to an increasingly horizontal perception of architectural production through the ages. During its evolution, the historiographic discourse grew complexified through a twofold understanding of space, both in terms of doctrinal conceptualization (space being presented as the very essence of architecture) and in terms of a geographical expansion. Several threads wove the historiographical narratives in the succeeding works of architectural history; unraveling these begins with an analysis of the foundations of architectural historicity, questioning the role and place of conceptual models, such as the ‘primitive hut’, and schemes like the ‘tree of architecture’, moving to a gradual dismantling of its temporality through the shaping of a modernist historiography and, eventually, through the emergence of marginal historiographic territories. An indirect goal of looking at this flattening of history from an architectural history perspective is tackling the meaning of writing history today.
Covid-19 research evidence: An international survey exploring views on useful sources, preferred formats, and accessibility
Authors: Tomlinson Eve , De Silva Debra , Stojanova Jana , Parker Roses , Umoquit Muriah , Lagosky Stephanie , Schmidt Bey-Marrié , Head Karen
Published: March 2022

INTRODUCTION: In a pandemic, stakeholders such as policy makers, clinicians, patients, and the public need access to high-quality, timely, relevant research evidence in a format that is understandable and applicable. OBJECTIVES: An online survey was used to determine where a global audience finds research evidence about COVID-19 and how they prefer to keep up to date. METHODS AND MATERIALS: We conducted an online survey of people interested in research in English and Spanish. We used a convenience sample of people visiting websites and social media accounts of Cochrane, an international organisation that collates systematic reviews of research.  RESULTS: 831 people with various roles and locations responded over a short period with little active promotion. Healthcare professionals, members of the public, and policy influencers wanted research evidence to inform decisions about COVID-19. More than half found research evidence from government websites (52%), international organisations (57%), journals (56%), and evidence collation organisations (60%) useful. People wanted research evidence about COVID-19 formats such as lay summaries (60%), online systematic reviews (60%), short summaries with commentaries (51%), and visual summaries (48%). People preferred to be kept up to date about COVID-19 research via email updates and newsletters, tailored to people’s interests (34%), traditional media (13%) and social media (12%). CONCLUSIONS: It was feasible to collect feedback rapidly using a simple online survey. Websites from official organisations were key sources of COVID-19 research evidence. More research is needed on how best to provide evidence that is easy to access and understand.
High-throughput and cost effective pan trap DNA extraction v1
Authors: P Cuff Jordan , JN Kitson James
Published: March 2022

This protocol is designed for extracting DNA from pan trap-collected invertebrates for biomonitoring and community metabarcoding. The reagents and methods proposed offer a cost effective and high-throughput method for molecular diversity analyses of bulk samples using standard lab equipment.
[RETRACTED] Strive Keto Reviews: Shocking Strive Nutrition Keto Report Reveals Must Read Before Buying v1
Authors: Nutrition Keto Strive
Published: March 2022

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Strive Keto Reviews: Shocking Strive Nutrition Keto Report Reveals Must Read Before Buying
[RETRACTED] ProVacan CBD Gummies Reviews - Shark Tank Scam Reports 2022 v1
Authors: not provided provacangummiesreviews
Published: March 2022

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ProVacan CBD Gummies Reviews - Shark Tank Scam Reports 2022
[RETRACTED] Little Blue Gummies Reviews - Does CBD Gummy Bears Scam Or Legit? v1
Authors: not provided littlebluereviewslegit
Published: March 2022

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Little Blue Gummies Reviews - Does CBD Gummy Bears Scam Or Legit?
Kesenian Tarling: Pertunjukan Hiburan, Pendidikan, Media Komunikasi 1966-2000
Authors: Sartika Santi , Mulyana Agus
Published: March 2022

ABSTRAKPenelitian ini bertujuan untuk menguraikan perkembangan kesenian di Kabupaten Cirebon pada tahun 1966-2000. Secara garis besar, masalah utama yang dikaji dalam artikel ini mengenai “bagaimana perkembangan fungsi kesenian tarling di Kabupaten Cirebon tahun 1966-2000. Untuk membahas permasalahan tersebut penulis melakukan kajian dengan menggunakan metode historis yang terdiri dari empat langkah yaitu heuristik, kritik sumber, interpretasi dan historiografi. Berdasarkan hasil penelitian ditemukan kesimpulan bahwa ada tiga fungsi dalam pertunjukan kesenian tarling. Pertama tarling berfungsi sebagai media hiburan, kesenian tarling digunakan untuk hiburan melekan(menjaga semalam suntuk) menemani masyarakat yang membakar bata, pesta panen, dan acara hajatan. Sebagai media pendidikan terdapat suatu ajaran nilai dan moral dalam setiap drama dan lirik-lirik lagu tarling yang di pertunjukan. Sebagai media komunikasi yaitu dalam pertunjukan tarling seringkali dibawakan menggunakan bahasa daerah, sehingga kekuatan komunikasinya dapat menjangkau warga desa yang masih buta huruf. Hal tersebut dijadikan sebagai media komunikasi oleh pemerintah, untuk mengantarkan pesan-pesan pembangunan. Ketiga fungsi tersebut yang membuat kesenian tarling mempunyai keunikan tersendiri sebagai ciri khas dan jati diri masyarakat Cirebon sehingga harus tetap dilestarikan. Kata Kunci: Kesenian Tarling, Tarling Klasik, Kabupaten Cirebon.
Quick On the Draw Tingkatkan Keterampilan Kerjasama Siswa
Authors: Santika Santi , Supriatna Nana
Published: March 2022

Penelitian ini dilatarbelakangi oleh kurangnya keterampilan kerjasama siswa, sehingga berpengaruh pada proses pembelajaran, khususnya ketika dilaksanakannya diskusi kelompok. Penelitian ini dilaksanakan di kelas XI Unggulan SMA Pasundan 8 Bandung. Tujuan utama dari penelitian ini adalah meningkatkan keterampilan kerjasama siswa dalam pembelajaran sejarah. Indikator keterampilan kerjasama yang diukur pada penelitian ini, yaitu menggunakan kesepatan, mengatur dan mengorganisir, berada dalam diskusi kelompok, serta mengambil giliran dan berbagi tugas. Adapun metode penelitian yang digunakan adalah metode Penelitian Tindakan Kelas (PTK) dengan menggunakan desain penelitian Kemmis dan Mc Taggart yang terdiri dari empat tahapan, yaitu perencanaan (plan), pelaksanaan (act), observasi (observation), dan refleksi (reflection). Penelitian ini dilakukan sebanyak tiga siklus. Berdasarkan analisis data yang telah dilakukan, perkembangan siswa dalam mencapai kriteria indikator keterampilan kerjasama yang telah ditentukan mengalami peningkatan dari setiap siklusnya. Hal ini dapat terlihat dari perolehan skor setiap indikator pada setiap siklusnya yang mengalami peningkatan. Hal ini menunjukkan keberhasilan dari penerapan metode Quick On the Draw dalam meningkatkan keterampilan kerjasama siswa.This research is concerned with the lack of cooperation skills of students, so the effect on the learning process, especially when the implementation group discussion.This research is being conducted in Class XI Unggulan SMA Pasundan 8 Bandung. The main purpose of this research is to improve the cooperation skills of students in learning history. The indicator to measure cooperation skills in this research is to using the agreement, organizing, being in groups, and taking turns and sharing assignments. This reseach uses the classroom action research designed by Kemmis and Mc Taggart which consists of four stages: planning, acts, observation and reflection. This research was conducted in three cycles. According to the data that has been analysed, there’s an increase on every cycle in th students developments to reach the criteria of cooperation skills indicator, this can be seen by looking at the scores on every indicator in each cycle. This shows success at the applying in the method Quick On The Draw in improving the cooperation skill of students.
Potret Keberadaan Kesenian Wayang Kulit di Bekasi: Wayang Kulit Akulturasi (Periode Tahun 1970-2015)
Authors: Wardani Dalila Kusuma , Saripudin Didin
Published: March 2022

This article aims to describe the development of wayang kulit in Bekasi in 1970-2015. Broadly speaking, the main problem studied in this article is about "How is the existence of wayang kulit in Bekasi in the midst of the rapid pace of globalization in 1970-2015?". The author uses historical methods consisting of four steps: heuristics, source criticism, interpretation, and historiography. Based on the results of research in its development, wayang kulit in Bekasi experienced dynamics in the span of 1970-2015. In the 1970s this art is in great demand by the public, it can be seen from the intensity of the performance is very dense. But entering 2015 the intensity of wayang kulit performances in Bekasi is decreasing. This indicates that the Betawi puppet was demoted by Betawi ethnic community it self and the society in general. Globalization is one of the factors that cause a decrease in public interest in traditional arts.
Perkembangan Pondok Pesantren Al-Musyarrofah di Kabupaten Cianjur Tahun 1975-2014
Authors: Ayuningtyas Widinia Dinda , Santosa Ayi Budi
Published: March 2022

Skripsi ini berjudul “Perkembangan Pondok Pesantren Al-Musyarrofah di Kabupaten Cianjur Tahun 1975-2014”. Ketertarikan penulis mengkaji mengenai Pondok Pesantren Al-Musyarrofah berdasarkan pada keterpaduan pondok pesantren tradisional dengan pendidikan formal yang berkembang pesat dari peningkatan jumlah santri tiap tahunnya, selain itu penerapan kurikulum atau metode pengajaran Kulliyatul Mu’allimin wal Mu’allimat al Islamiyah, dan para santri di Pondok Pesantren Al-Musyarrofah yang berasal dari seluruh wilayah Indonesia. Adapun masalah utama yang dibahas dalam skripsi ini adalah “bagaimana perkembangan Pondok Pesantren Al-Musyarrofah di Cianjur Tahun 1975-2014?. Kemudian masalah utama tersebut dibagi ke dalam empat pertanyaan penelitian, yaitu: bagaimana latar belakang berdirinya Pondok Pesantren Al-Musyarrofah?; bagaimana kondisi  Pondok Pesantren Al-Musyarrofah dibawah kepemimpinan KH. Wildan Affandi; bagaimana perkembangan lembaga pendidikan yang terdapat di Pondok Pesantren Al-Musyarrofah?; apa saja faktor pendorong dan penghambat dalam perkembangan Pondok Pesantren Al-musyarrofah?. Metode yang digunakan dalam penelitian ini adalah metode historis, menggunakan langkah-langkah sebagai berikut: heuristik, kritik eksternal dan internal, interpretasi atau penafsiran sumber dan historiografi yang meliputi latar belakang berdirinya pondok pesantren, kondisi Pondok Pesantren Al-Musyarrofah dibawah kepemimpinan KH. Wildan Affandi, perkembangan lembaga pendidikan yang terdapat di Pondok Pesantren Al-Musyarrofah, faktor-faktor pendorong dan penghambat dalam perkembangan Pondok Pesantren Al-Musyarrofah. Merujuk pada hasil penelitian diperoleh beberapa kesimpulan. Pondok Pesantren Al-Musyarrofah didirikan pada tahun 1833 oleh Syeikh Tb. Abdullah Umar Syarifuddin. Kepemimpinan Pondok Pesantren Al-Musyarrofah sudah mengalami pergantian hingga enam generasi. Modernisasi pesantren terjadi pada tahun 2008 dengan mendirikan SMP Islam Terpadu (SMP IT). Pondok Pesantren Al-Musyarrofah tidak menerima adanya santri kalong, akan tetapi pihak pesantren hanya menerima santri mukim saja.
Meningkatkan Keterampilan Membaca Kritis Buku Teks dalam Belajar Sejarah Melalui Metode Search, Solve, Create and Share (SSCS)
Authors: Rosita Rita -
Published: March 2022

Students’ critical reading skill is being decreasing, especially in learning history. In the other hand, students’ reading skill during learning history is important and has its significance to be developed. The indications can be seen from the ability on finding and comparing reading sources, analyzing readings, making notes from reading results, and sharing information from reading analysis results. Due to the significance of this research, author formulates some problems taken, those are: first, how to develop history learning using methods Search, solve, create, and share (SSCS). Second, how to implement the search, solve, create, and share methods (SSCS). Third, how to increase learning using the search, solve, create, and share methods (SSCS). Fourth, the efforts to overcome the obstacles arisen in the application of search, solve, create, and share (SSCS) method. This study aims to improve critical reading skills of student's history textbook during learning history. This study uses a classroom action research model with Kemmis and Taggart design consisting of planning, implementation, observation, and reflection. This study aspects of the textbook's Critical reading skills are selecting information from the historical textbook that corresponds to the discussion, finding information from the history textbooks, analyzing the content of the reading in the history textbooks, asking questions to the teacher or friends about the learning materials in the history textbooks, making notes based on the readings from the history textbook, sharing the work based on the reading results. Based on the results, this search, solve, create, and share (SSCS) may improve Students’ critical reading skill in history learning . This is indicated by the increase in the critical reading skill on textbook of the learning process in each cycle.
Student Debate Club dalam Pembelajaran Sejarah
Authors: Al Giffari Firdaus , Wiyanarti Erlina , Ma'mur Tarunasena
Published: March 2022

ABSTRACTArgumentation skills are included in the 4C competencies (Creative, Critical Thinking, Communicative, and Collaborative). This research is the application of learning techniques with the student debate club method which can make students more active by developing speaking skills in following lessons, especially in terms of expressing their opinions or arguments. In this study, the cycle used was three cycles in which each cycle carried out one action using the Class Action Research (PTK) model designed by Kemmis and McTaggart whose processes consisted of planning, implementing, observing, and reflecting. The choice of CAR is to be able to change and improve the quality of learning according to the planned goals. Sub indicators regarding the argumentation skills used are confident in arguing, not questioning whether or not an argument is true, a clear voice, fluent when speaking, appreciating other people's arguments, criticizing other people's arguments wisely, presenting arguments logically and analytically, and presenting arguments based on argumentation.ABSTRAK Kemampuan argumentasi terdapat dalam kompetensi 4C (Creative, Critical Thinking, Communicative, dan Collaborative). Penelitian ini merupakan penerapan teknik pembelajaran dengan metode debat (student debate club) yang dapat mejadikan siswa lebih aktif dengan mengembangkan kemampuan berbicara dalam mengikuti pembelajaran terutama dalam hal mengemukakan pendapat atau argumentasinya. Dalam penelitian ini, siklus yang dipakai yaitu sebanyak tiga siklus dimana masing-masing setiap siklusnya dilakukan satu tindakan dengan menggunakan model Penelitian Tindakan Kelas (PTK) desain Kemmis dan McTaggart yang prosesnya terdiri atas perencanaan, pelaksanaan, pengamatan, dan refleksi. Pemilihan PTK ini agar mampu mengubah dan meningkatkan kualitas pembelajaran sesuai dengan tujuan yang telah direncanakan. Sub indikator mengenai keterampilan argumentasi yang dipakai yaitu percaya diri dalam mengemukakan argumentasi, tidak mempermasalahkan benar salahnya argumentasi, suara terdengar jelas, fasih ketika berbicara, menghargai argumentasi orang lain, mengkritik argumentasi orang lain dengan bijaksana, menyampaikan argumentasi secara logis dan analitis, dan menyampaikan argumentasi berdasarkan olah argumentasi.
Inflammatory myofibroblastic liver tumor
Authors: Kaprin A. D. , Ivanov S. A. , Nevolskikh A. A. , Petrov L. O. , Isaeva A. G. , Zibirov R. F. , Izmailov A. A.
Published: March 2022

Inflammatory myofibroblastic tumors (inflammatory myofibroblastic tumors) IMT in the clinical practice of an oncologist are very rare diagnostic findings. Currently, the bulk of scientific publications about IMT are devoted to reviews of clinical cases. If initially IMT were considered as pseudo-tumors, now they are classified as intermediate fibroblastic/myofibroblastic tumors according to the WHO histological classification. Management of patients with hepatic IMT are debatable today. Hepatic IMT are mostly benign lesions and characterized by spontaneous regression without any treatment. However, sometimes therapeutic and surgical treatment of these lesions is necessary. Many authors recommend surgical treatment, as with conservative treatment, some patients develop relapses. This rare observation demonstrates our experience of liver resection for inflammatory myofibroblastic liver tumor in 76 year-old patient.
Cytopathological characteristics for provoked lesions of squamous epithelia of digestive system in animal models
Authors: Shestakova V. G. , Nigmatullina L. I. , Atadzhanov I. B. , Donskov S. A. , Kozlovskaya Yu. V. , Dolgopolov I. S. , Rykov M. Yu.
Published: March 2022

Purpose of the study. Investigation of morphological characteristics of changes in the epithelium of foregut in experimental animals put under conditions of provoked carcinogenesis.

Materials and methods. The method of chronic experiment on animals is applied: 40 female non-linear white rats, which are divided into 4 equal groups (n = 10). The first (I) and second (II) control groups of animals were exposed to mechanical trauma of the oral mucosa with additional application of 0.9 % NaCl solution and 1 % aqueous dimethyl sulfoxide (DMSO) solution with a frequency of 2 times a week. The third group of animals, i.e. the main group (4-NQO), was subjected to mechanical traumatization of the oral mucosa with additional application of 1 % DMSO aqueous solution containing 0.1 mg/ml of 4 nitroquinoline-N-oxide, with a frequency of 2 times a week. The fourth group of animals was intact. On the 1st, 7th, 10th, 14th day from the beginning of the experiment, and then every 14 days, cytological material was taken from the oral mucosa and stained with Papanicolaou stain. To compare the emerging changes, the histological picture of the organs of the foregut was studied.

Results. Animals from the main group (4-NQO) showed a lag in body weight gain over the standard variance in the control (I and II) and intact groups. Atypical cells of indeterminate significance appeared in smears starting from 42 days of the experiment. Starting from the 56th day of the experiment, atypical cells (1–2 in the field of view), described in Bethesda terms as low-grade intraepithelial lesions, were detected in smears obtained from the main group of animals (4-NQO). Parabasal cells of the squamous epithelium with atypical large (more than 3 times compared to the reference) nuclei, anisonucleosis, with variable contours of the nuclear membrane within one cell, coarse chromatin were recognized as diagnostically significant.

Conclusion. The severity of morphological changes in foregut epithelium in the direction of the precancerous state is significantly higher in the main group with prolonged exposure to carcinogenic factor, compared with the control and intact groups (р < 0.05). Thus, the effectiveness of modeling the conditions of provocation of carcinogenesis of the epithelium of the upper digestive tube in experimental animals was studied and proved by mechanical traumatization of the oral mucosa with additional application of carcinogen (4-NQO). This model of provocation of carcinogenesis will be used in the next study of neoplastic processes of the female reproductive system.
Correction of thrombohemorrhagic syndrome in patients with widespread soft tissue phlegmon and sepsis
Authors: Tseimakh E. A. , Zinchenko V. Yu. , Lavrinenko O. Yu. , Chernenko V. V. , Kalashnikov A. V. , Shalabod E. A. , M. Tseimakh M. E.
Published: March 2022

Purpose of the study. Analysis of the effectiveness of cryoprecipitate – antienzymatic with common soft tissue phlegmon and sepsis.

Patients and methods. To achieve the intended goal, a study of the results of treatment of 92 patients with a diagnosis of advanced soft tissue phlegmon and sepsis was performed. All patients underwent a comprehensive diagnostic study with an in-depth study of the indicators of the hemostasis system. For a comparative assessment, 2 groups of patients were identified. Group 1 (46 (50 %) patients – the main one) – received cryoprecipitate-antienzymatic therapy as part of complex treatment, group 2 (46 (50 %) patients – comparisons) – received only the generally accepted basic treatment.

Results. An in-depth study of the hemostasis system in patients with widespread soft tissue phlegmon and sepsis indicated the development of thrombohemorrhagic syndrome, which was manifested by depletion of both the coagulation and anticoagulation systems of the blood, a drop in AT III, an increase in thrombinemia and fibrinolysis depression. In order to correct thrombohemorrhagic syndrome, a cryoprecipitate-antienzymatic complex was included in the complex treatment of patients with widespread soft tissue phlegmons and sepsis, aimed at unblocking microcirculation in inflammatory foci and parenchymal organs, to improve the penetration of antibacterial drugs and other drugs into these foci, thereby stopping inflammation and preventing the increase of multiple organ failure. The effectiveness of the cryoprecipitate-antienzymatic complex was evaluated based on clinical data of the course of the purulent – inflammatory process and the results of indicators of the hemocoagulation and fibrinolysis system on 8–10 days from the start of therapy.

Conclusion. The use of cryoprecipitate-antienzymatic complex, which includes freshly frozen plasma (FFP), heparin, proteinase inhibitors, in patients with widespread soft tissue phlegmon and sepsis effectively eliminates thrombohemorrhagic syndrome, which improves microcirculation in purulent – inflammatory foci and affected parenchymal organs, improving the flow of antibacterial drugs into these foci. At the same time, there is an improvement in the course of the wound process, so the wounds are cleaned faster from necrotic masses and filled with healthy granulation tissue, which makes it possible to perform plastic closure of the wound defect 1.6 times faster. Mortality is reduced by 2.2 times and the number of thrombotic and thromboembolic complications in the structure of deaths is reduced.
Pharmacological support in the perioperative period of implantation of a polypropylene mesh prosthesis (experimental study)
Authors: Lukoyanychev E. E. , Izmajlov S. G. , Leontev A. E. , Mironov A. A. , Nikolskij V. O. , Evsjukov D. A. , Emelyanov V. A.
Published: March 2022

Purpose of the study. was to improve the technology of prosthetic repair of the anterior abdominal wall patients with hernias by means of pharmacological regulation of the local and systemic inflammatory response and stimulation of reparative regeneration.

Materials and methods. The study was carried out on 52 pure line rats in vivarium. All animals have on-lay implantation of a polypropylene mesh imlantant. Group I have no specific pharmacological treatment receive (0.9 % sodium chloride solution); group II – receive solution of xymedon, group III – potassium orotate, group IV – methyluracil.

Results. Identified that all investigated drugs of the pyrimidine series (xymedon, potassium orotate, methyluracil) have a significant effect on the local and systemic inflammatory process. The growth of IL 10 and TNF-a are associated with an increase in the area of liquid inclusions. The use of potassium orotate and methyluracil in the postoperative period is inappropriate, as it is associated with an increased risk of hemorrhage and acute paraprosthetic fluid accumulations. Taking xymedon after surgery is associated with an accelerated growth of blood vessels and granulation tissue, a decrease in fluid inclusions, but is associated with an insignificant increase in the risk of tissue hemorrhage.

Conclusion. Pharmacological regulation of inflammatory and regenerative processes with xymedon in the perioperative period of prosthetic repair could guide the development of surgical treatment of patients with abdominal hernias, which requires further clinical study.
THE PLACE OF THE RUSSIAN ORTHODOX CHURCH IN THE STRUCTURE OF IMPERIAL POWER: PARADIGM OF GOLDEN HORDE
Authors:   Research Institute of Ukrainian Studies of the Ministry of Education and Science of Ukraine, Krysachenko Valentyn
Published: March 2022

The Russian Orthodox Church (ROC) has its origins in the establishment of the Golden Horde occupation authorities in the north-eastern territories of Kievan Rus. At this time, the Kyiv metropolitanate of the Patriarchate of Constantinople was faced with a choice: «with whom to be?» — with the invaders, or with their own people. The vast majority of its clergy and laity are Kyiv, Chernihiv, Pereyaslav, Halych-Volyn, and others. principality) chose the path of struggle for independence, and the other (Vladimir, Suzdal, Moscow) — close cooperation and obedience to the new government. The rulers of the Golden Horde themselves were guided by the laws of Iasi, with its postulates about the divine essence of the ruler, and local beliefs (including Orthodoxy) were pragmatically used in their own interests. Instead, the clergy and church property fell under the direct subordination of the khan, and the faithful service of the hierarchs was supported by labels — personalized privileges. In this context, a conscious choice was made to serve the Horde by Metropolitans Kirill and Maxim, who adapted church norms to the requirements of the authorities, built infrastructure, established new dioceses, including the capital, in Sarai-Batu, and so on. The latter was demonstratively translated, ie expropriated, from Pereyaslav, Dnieper, with a corresponding change of name to Saraisk. In the Horde, the ROC became part of the state mechanism for managing the occupied territories and population, participating in the redistribution of power, property and resources. Methods of terror, spiritual violence, denationalization, etc. were used for everyday use, and bribes and access to looted and official success were used to recruit the faithful. Since then, the discourse of lies and deception has also been adopted as the defining communicative strategy. These Golden Horde archetypes have formed a strategic paradigm for the functioning of the ROC as an integral part of imperial power, which it is trying to implement in modern conditions. A clear confirmation of this is the participation of the ROC in promoting the ideas of the «Russian world» and direct participation in the establishment of occupation regimes in the Crimea and ORDLO.
«APOLITICAL» OF P. KULISH — CULTURIST OF CYRIL AND METHODIUS BROTHERHOOD
Authors:   Taras Shevchenko National University of Kyiv, Obushnyy Mykola , Kurylenko Anastasiia ,   Taras Shevchenko National University of Kyiv
Published: March 2022

The purpose of the research is to analyze the political component of the activity of the culturist of the Cyril and Methodius Brotherhood P. Kulish, which is poorly studied in the domestic socio-humanitarian studies, and its «apolitical nature». It has been proved that the fact that P. Kulish considered politics «heartless and deaf» and called for «neglect of politics» cannot be a confirmation that P. Kulish was an apolitical man. The methodology of work is based on the principles of historicism, impartiality, integrativity, systematics, objectivity with the use of general scientific methods. The analysis of the activity of the culturist Panteleimon Kulish shows that in all its multifaceted cultural and educational work, politics as a component of the life of every person, of course, was present in P. Kulish. The mere fact that P. Kulish has repeatedly stated that politics is «heartless and deaf» and even called on Cyril and Methodius to neglect politics «cannot and does not mean that P. Kulish was out of politics. In fact, P. Kulish was constantly in politics, although he often hid it «under a lampshade. » And in this context, it is probable that P. Kulish can be understood if we take into account all the hardships he had to go through after his arrest as a member of the Cyril and Methodius Brotherhood, and then more than three years in exile in Tula with a ban on publishing for almost 10 years. All this indicates that P. Kulish, being a versatile and encyclopedically educated man, was able to separate grain from chaff, and, consequently, populism from politics.
THE EU MIGRATION CRISIS AS A CHALLENGE TO EUROPEAN REGIONAL SECURITY
Authors:   National University of «Kyiv-Mohyla Academy», Taranenko Anna
Published: March 2022

The EU migration crisis is analyzed as a challenge to European regional security. The used method is historical and comparative. As a result, it can be stated that migration is a global trend which has become especially dynamic in the second half of the 20th. Dynamic migration processes, in their turn, stipulate the importance of efficient ethnic policy of recipient states. Since 2015 the European Union authorities took measures in order respond to the migration crisis effectively, strengthen regional security and enhance borders control. The EU makes further efforts in order strengthen intersectoral cooperation between various political and security agencies responsible for tackling the migration crisis. To a certain extent, the migration crisis of 2015 posed a threat to the European Union unity and security and also raises questions about further integration of the European Union. The migration crisis has demonstrated that the EU needs to efficiently adapt its security strategy to new challenges. It can be concluded that the current migration crisis processes in the EU challenge further European integration and regional European security. Core democratic values have been challenged by the migration crisis, in particular, freedom of movement and civil protection and in order to enhance regional security in Europe one can further utilize the civil society potential and track-II diplomacy instruments.