bluuebunny/crossref_metadata_2025 huggingface dataset:
A Development of Contraction-Expansion Microfluidic Device for Detecting Microfilaria in Blood
Authors:   , Uthongsap Saktip
Published: November 2023

The objective of this research is to detect the microfilariae in blood by using filtration microfluidic chip. From the preliminary experiment, the main problem is the concentration of red blood cells. These red blood cells clogged and blocked the microfilariae from the observation. In this part of the research, contraction and expansion array was chosen to solve the stated problem. The channel in the chip is 60 μm. The width of contraction and expansion channel is 50 μm. For the length of expansion chambers, there are 500 and 1,000 μm. In each chip, the expansions were connected in series. The experiments were done to determine the efficiency by using polystyrene beads with 4 sizes; 5, 10, 15, and 20 μm. The Reynolds number of 40, 60, 80, 100, and 120 were selected for the experiments. Afterward, the whole blood of the dog together with normal saline solution was injected to determine the separation efficiency of the microfilaria of the chip. The chip could separate 100% of microfilariae to the main outlet.
Effect of filter on average glandular dose and image quality in digital mammography
Authors:   , Songsaeng Chatsuda
Published: November 2023

The purpose of this study is to determine the average glandular dose, AGD and the image quality in phantom and patient for different target-filters (W/Rh and W/Ag) of the digital mammography system. The ACR mammography phantom and BR 12 phantom were used to determine the AGD and the image quality, the contrast to noise ratio (CNR) and the signal to noise ratio (SNR) of various target filters in different phantom thickness. A retrospective mammography study includes 200 patients which 100 patients were examined using the W/Rh target-filter and 100 different patients using W/Ag target-filter. The compressed breast thickness (CBT, mm), compression force (lbs), average glandular dose (AGD, mGy), peak kilovoltage (kVp) and tube current time (mAs) were recorded and compared between W/Rh and W/Ag target. The result in the phantom study, at the same thickness, the CNR and SNR values were decreased with increasing tube voltages in AEC technique. At the manual technique, when the tube voltage was constant and tube current time was increasing, CNR and SNR were increased. This was agreeable for both W/Rh and W/Ag target-filters. In patient study, the mean AGD, CBT, CF, kVp, mAs of W/Rh were 1.26 mGy, 54.18 mm, 13.24 lbs., 29.68 and 106.75 respectively in CC view. The mean AGD, CBT, CF, kVp, mAs of W/Ag was 1.79 mGy, 81 mm, 14.15 lbs., 31.79 and 113.34 respectively. At 40 mm CBT, the optimal tube output for W/Rh range from 27 to 29 kVp and mAs range from 58 to 129, the AGD range from 0.82 to 1.15 mGy. The optimal tube output for W/Ag range from 30 to 35 kVp and mAs range from 145 to 200, the AGD range from 1.28 to 2.97 mGy. For compress breast thickness range from 40 mm to 60 mm, the W/Rh target-filter should be chosen and the CBT greater than 70 mm, the W/Ag target-filter is appropriate in order to compensation between good image quality and dose reduction. Conclusion in patient study, the determination of patient dose in King Chulalongkorn Memorial Hospital in 2016-2017 revealed that the mean AGD was 1.26 mGy, the mean CBT was 54.18 mm for W/Rh. The mean AGD was 1.79 mGy, the mean CBT was 81 mm for W/Ag. In our study, 2.5% of the patients received the average glandular dose over the diagnostic reference level of 3 mGy per view.
Patient Dose Measurement in TACE and PTBD Procedures Using Scintillation with Optical Fiber Dosimeter
Authors:   , Teankuae Saiwaroon
Published: November 2023

The scintillation dosimeter is most suitable for skin dose measurement for its small size of detector, easily use and there was no need to estimate the surface area exposure. However, scintillation detector could identify the result in limited area because of the small size of detector. During the procedure to identify the selected vascular supply tumor, the CT was scanned in patients which increasing the surface dose. TransArterial ChemoEmbolization (TACE) procedure and Percutaneous Transhepatic Biliary Drainage (PTBD) are the procedures producing high dose to both patients and staff. Radiation skin injury to patient was reported by these interventional procedures. The objective of this study is to determine patient skin dose measured by the scintillation detector, MIDSOF. TACE procedure using Angiographic and CT systems, PTBD procedure using Angiographic system, manufactured by Toshiba Medical System Corporation at Interventional Radiology Unit, King Chulalongkorn Memorial Hospital, the patient skin dose was measured by MIDSOF dosimeter. The patient data, the air kerma area product (KAP) and DLP had been recorded. The equivalent dose was calculated from DLP (mGy.cm) values displayed on CT console and from KAP (Gy.cm2) displayed on fluoroscopic procedures. TACE procedure included fifty-four consecutive patients (11 female and 43 male) during the period of July 2016 to February 2017. The mean ± SD of age, height, weight and BMI were 63.3±9.9 years, 164±8.4 cm, 65.7±10.1 kg and 24.4±3.4 kg/m2 respectively. The mean ± SD of fluoroscopic time, total number of radiographic frames were 33 ± 15 min and 220 ± 194 respectively. The mean ± SD of patient skin dose was 1.71 ± 1.14 (0.023 – 5.48) Gy. The mean ± SD of patient dose determined by KAP was 379.88 ± 147.78 (59.9 – 725.2) Gycm2. The correlation, r between the air kerma area product, KAP (Gycm2) and patient skin dose determined by MIDSOF (Gy) was 0.76. The mean equivalent dose with range of fluoroscopic and CT procedures were 70.86 (15.57-188.55) and 6.93 (3.19 - 20.47) mSv respectively. PTBD procedure included eight consecutive patients (2 female and 6 male). The mean ± SD of KAP values were 21.9 ± 26.9 (1.67 – 87) Gy.cm2. The mean ± SD of the equivalent dose and range was 5.69 ±7.01 (0.43– 22.6) mSv. The mean ± SD of patient absorbed dose and range were 0.14 ± 0.21 (0.004 - 0.7) Gy. In this study, 12 patients from TACE procedure received the skin dose exceed 2 Gv for erythema and epilation at prompt and early exposures.
Size-Specific Dose Estimates for Thoracic Imaging in 320 Row Detector Computed Tomography
Authors:   , Yoykaew Saowapark
Published: November 2023

The patient dose from CT scan is normally displayed in Dose Length Product (DLP) and volume CT dose index (CTDIvol). Actually, CTDIvol represents the scanner output, does not address patient size, can be used to estimate patient radiation dose but the dose value is inaccurate as it is estimated from the cylindrical phantom of particular size. AAPM Report no.204 [1] introduced in 2011 and AAPM Report no.220 [2] introduced in 2014 on the size-specific dose estimates (SSDEs) for CT examination in order to provide high accuracy on radiation dose to the patient. The purpose of this study was to determine the patient radiation dose using SSDEs for thoracic imaging in 320 MDCT and the parameters influenced SSDEs. This study is retrospective analysis with 230 patients, 115 male and 115 female of the age range from 18 to 93 years old, the selected weight range from 40 to 70 kg. All of the patients underwent the thoracic contrast enhancement with venous phase protocol scanned by 320 MDCT. The patient radiation dose in terms of SSDE was calculated based on AP+LAT dimension, effective diameter, and water equivalent diameter. The conversion factors following the body size and composition according to the AAPM no.204 and 220 recommendations were applied. SSDE was measured from middle slice of chest and middle slice of scan range. The results showed that the SSDE calculated from the middle of scan range was a little higher than SSDE calculated from middle of organ. At the middle slice of organ, the range of SSDEAP+LAT SSDEEFF and SSDEDw were 10.50-24.45, 10.43-24.25 and 11.66-26.83 mGy respectively. At the middle slice of scan range, the range of SSDEAP+LAT, SSDEEFF and SSDEDw were 10.83-24.85, 10.70-24.70 and 11.33-27.13 mGy respectively. The correlation of CTDIvol, body weight, BMI, AP+LAT dimension, effective diameter and water equivalent diameter with SSDE were moderately linear relationship. In conclusions, SSDE had been estimated using 3 methods (SSDEAP+LAT, SSDEEFF and SSDEDw) of body configurations in CT dosimetry. SSDEDw is most appropriate for determination as the CT patient dose indicator further from CTDIvol especially in various body sizes and body composition in thorax region.
Effect of auto anti-double stranded DNA on mesangial cells microrna profiles
Authors:   , Tangtanatakul Pattarin
Published: November 2023

Autoantibodies-mediated inflammation at the resident kidney cells is crucial in the lupus nephritis (LN) pathogenesis.  The objective of this study is to investigate the role of miRNA in human mesangial cells (HMCs) stimulated with auto anti-dsDNA IgG antibodies.  The cells were treated with antibodies purified from active LN patients or non-specific IgG controls in the present of normal serum.  The aberrant miRNA was screened using high throughput sequencing.  Results showed that anti-dsDNA IgG upregulated 103 miRNAs and down-regulated 20 miRNAs which regulate genes in the cell cycle, catabolic process, regulation of transcription and apoptosis signaling.  The miR-10a, which was listed in the top ten high abundance miRNA in HMCs, was specifically downregulated upon anti-dsDNA IgG induction.  Interestingly, the expressions of miR-10a in kidney biopsy from LN patients (n=29) were downregulated compared to cadaveric donor kidney (n=6). The downregulation was correlated with proteinuria, which is the earliest sign of renal defect (r2 = 0.5266, p-value = 0.0115).  Functional studies highlight the downstream regulator of miR-10a in the chemokine signaling and cell proliferation or apoptosis pathway.  The luciferase assay confirmed for the first time that IL-8 was a direct target of miR-10a in HMCs.  In conclusion, anti-dsDNA IgG Ab down-regulated miR-10a expression in HMC resulting in the induction of various target genes involved in HMCs proliferation and chemokine expression.  Manipulation of miR-10a might be a new option for targeted therapy for LN.
Genetic variation of glycoprotein d within herpes simplex virus isolated from clinical specimens
Authors:   , Naemkhunthot Sirirat
Published: November 2023

Herpes simplex virus (HSV) distributing worldwide, belongs to family Herpesviridae, subfamily alphaherpesvirinae. There are 2 serotypes, i.e., HSV-1 and HSV-2. The initial infection starts by using glycoprotein D (gD) contact to host cell surface receptors resulting to viral entry by membrane fusion. Moreover, gD can induce the production of neutralizing antibody. Therefore, mutations of HSV gD are critical for viral growth in cells which might affect cell pathology and pathogenesis of diseases. The objective of this study is to investigate the variations of HSV gD. One hundred samples were selected by using systemic sampling from 256 clinical specimens during the year of 1999 – 2010. Only 70 samples were successfully isolated. They were typed by Real time PCR revealing 37 were HSV-1 and 33 were HSV-2. After that, gD gene was amplified and DNA sequencing. The results were compared to the sequences previously reported in GenBank. From nucleotide sequencing data, HSV-1 gD of 13 patterns were different from HSV-1(KOS) reference strain. While HSV-2 gD showed 9 patterns differed from HSV-2 (HG52) reference strain. Mutation was the major mechanism of variation. Only 6 positions had non-synonymous amino acid changes. After phylogenetic tree was constructed, the variations of HSV-1 gD and HSV-2 gD were distinctively separated. However, intratypic variation was very low. In conclusion, HSV gD from clinical specimens had low variations. HSV-1 gD had more divergent than HSV-2. The major cause of variation was synonymous point mutation. Therefore, HSV gD is a good candidate for vaccine development.
Insecticidal activity of Thai botanical extracts against German cockroach, Blattella germanica (l.) (Orthoptera : Blattellidae)
Authors:   , Saenmanot Soraya
Published: November 2023

German cockroach, B. germanica is considered an important medical and economic pest in Thailand because they can carry many pathogens, such as bacteria, virus and protozoa to humans. The objective of this study was to evaluate the efficacy of extracts derived from six Thai botanicals, which including Piper retrofractum, Stemona tuberosa, Derris elliptica, Rhinacanthus nasutus, Butea superba and Foeniculum vulgare against various developmental stages of B. germanica under laboratory conditions.

Different concentrations of extract derived from six Thai botanical (2, 4, 6, 8 and 10%) (% w/v) were used to exposure to various developmental stage including nymphs, adult and gravid females stage of B. germanica by topical application method. The mortality was assessed at 1, 2, 4, 6, 24 and 48 hours after the exposure. Data was statistically analyzed by using analysis of variance (ANOVA) and Duncan’s multiple range test (DMRT). LD50 were calculated by the Probit analysis program. Moreover, the major component of Thai botanical extract that had highest insecticidal activity was analyzed by column chromatography and thin layer chromatography (TLC).

The results showed that Thai botanical extracts derived from P. retrofractum have the highest mortality on various developmental stage of B. germanica at every experimental time intervals. Moreover, the acetone extract of P. retrofractum at highest concentration (10% w/v) showed complete insecticidal activity (100%) against both adult (LD50 2.61) and gravid females stages (LD50 1.97) of B. germanica after 6 hours post exposure. The fraction 5 of acetone extract of P. retrofractum obtained from TLC analysis was showed highest efficacy against B. germanica and the major component was identified as piperine.

Therefore, extracts of P. retrofractum can be used as an alternative natural insecticide for the controlling of B. germanica which are inexpensive and safe for humans and the environment. However, insecticidal activity of the Thai botanical extracts against B. germanica in field environment and appropriate formulations of this extracts should be determined.
Cellular Mechanism of Flavonoid Derivatives Inhibiting Dengue Virus Infectivity
Authors:   , Suroengrit Aphinya
Published: November 2023

Dengue virus infection is a global public health threat where specific treatment has not been established. Chrysin and flavanone derivatives were previously reported as potential anti-flaviviral inhibitors. We explored ten flavones, flavanones, chalcone, and anthraquinone derivatives that extracted and modified from natural products.Two chrysin derivatives showed inhibitory effects against DENV1-4 and ZIKV SV0010/15 infectivities with the EC50 values of 2.30±1.04, 1.47±0.86, 2.32±1.46, 1.78±0.72 and 1.65±0.86 µM of FV13 and 2.30±0.92, 2.19±0.31, 1.02±0.31, 1.29±0.60 and 1.39±0.11 µM of FV14 respectively. The CC50s to LLC/MK2 of FV13 and FV14 were 44.58±2.99 and 44.51±2.58 µM, respectively. Time of addition assay revealed that the primary target was at early after infection. We observed that the compound did not interfere with the viral attachment, but rather showed its highest efficacy at post-attachment with viral titer inhibition of 64.97±1.18% and viral RNA inhibition of 59.96±4.56%. To confirm the replication inhibition, we tested with BHK-21/DENV2 replicon cells. We found that viral replication inhibition of 10 µM FV13 was 75.38 ± 7.88 %. This report demonstrated for the first time as a potential candidates to inhibit the dengue and Zika infectivities with high efficacy at micromolar level that could be developed as a broad-spectrum anti-flaviviral drug. This study also provided insights in cellular toxicity, stability, and suggested possible drug targets for further optimization.
Isolation Of Pythiaceae From Para Rubber Hevea Brasiliensis In Eastern Thailand For Identification Of Pythiaceae Virus
Authors:   , Hattapanichaporn Chanoknan
Published: November 2023

Mycoviruses are viruses infecting fungi of which dsRNA genome is the most common. Mycovirus infection may confer the hyper and hypo-virulence phenotypes of fungi. This study focused on isolation of virus in Pythiaceae, a family of fungus-like organism. The members of this family are plant pathogens including Phytophthora, Pythium and Phytopythium. Species in Phytophthora cause abnormal leaf fall disease (ALF) in para rubber tree (Hevea brasiliensis). Pythiaceae were isolated from rubber leaves showing ALF symptoms collected from plantations in Chanthaburi and Rayong province, Thailand. All 79 Pythiaceae isolates were screened for extrachromosomal DNA and dsRNA elements. One isolate, R84 was found harboring 3 dsRNA element approximately 8.0, 3.7 and 2.3 kb. However, upon consecutive subcultures the only largest segment remained. Two-step reverse transcription using Pythiaceae virus specific primers revealed that the dsRNA was not one of reported Pythiaceae viruses. A partial cDNA clone of 233 nt out of the largest 8.0 kb dsRNA element contained a fragment of a gene encoding ALG2 mannosyltransferase-like protein but the genus of the dsRNA could not be specified. The dsRNA host was identified as Pythium cucurbitacearum, which has never been reported associated with rubber diseases. Isolate R84 showed hyper-resistance to hymexazol fungicide. The dsRNA found in this study might be responsible for resistant to fungicide of Py. cucurbitacearum isolate R84.
Terpenoid From Tuber Of Dioscorea Bulbifera And Modified Analogues With Suppressing Activity Against Osteoclast Differentiation
Authors:   , Sriploy Preeyapan
Published: November 2023

Osteoporosis is often found in elderly. There are many causes of osteoporosis such as life style, aging, gender. Osteoporosis is found in females rather than males, as a result of decreasing the level of estrogen in post-menopausal female. Osteoporosis is characterized by decreasing bone mass and bone tissue. Normally, bone remodeling is maintained by balance between bone formation and bone resorption. Therefore, the main cause of osteoporosis is an imbalance between osteoblasts and osteoclasts. As a result, the condition makes bone fragile and increased risk of fracture. Therefore, osteoclasts are the target of osteoporosis treatment. Nowadays, treatments of osteoporosis have several side effects. In this study, the chemical constituents of plants were investigated to potential develop for osteoporosis drug. One terpenoid isolated from tuber of Dioscorea bulbifera and 11 modified analogues of natural terpenoid were used in this study. All compounds were screened for the anti-osteoclastogenic activity murine bone-marrow-derived macrophage precursors. All tester compounds did not cytoxicity and anti-inflammatory activity in RAW 264.7. From anti-osteoclastogenic activity screening, we found that ASTP069, a modified analogue, significantly suppressed the differentiation of the tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells induced by receptor activator of nuclear factor-kB ligand (RANKL) with an IC50 of ASTP069 10.07±0.05 µM. At the transcription level, we found that ASTP069 clearly decreased the expression of nfatc1, ctsk and irf8 leading to inhibit osteoclastogenesis and osteoclast function. The effect of ASTP069 on signaling pathway was investigated. The results showed that ASTP069 decreased activation of NF-kB pathway but did not affect the activation of MAPK pathway by suppressing NF-kB p65 nuclear translocation. The results indicated that ASTP069 inhibited osteoclastogenesis by downregulation of nuclear factor of activated T cells (NFATc1) and the other osteoclast-related genes via NF-kB pathway. Therefore, the modified terpenoid from D. bulbifera has therapeutic potential for development as anti-osteoporosis drug.
Viability of Lactobacillus acidophilus in effervescent granules prepared via wet granulation method: in vitro study
Authors: Pratama Reza , Melinda Kholifa , Muhsinin Soni
Published: November 2023

Lactobacillus acidophilus, a strain of lactic acid bacteria widely used as a probiotic microorganism, has been extensively employed in developing probiotic products including in effervescent granules. This study's objectives were to ensure that the resultant granules possessed the desired physical attributes and retained the requisite viability of lactic acid bacteria. A wet granulation method was used. The formula was physically evaluated and analyzed using Design Expert software, followed by gram staining and bacterial harvesting. Gram staining verification demonstrated the gram-positive nature of the pure L. acidophilus bacterial isolates, as evidenced by their consistent purple coloration and characteristic basil shape. Evaluation of physical properties revealed organoleptic attributes such as granular shape, white coloration devoid of odor, flow rate of 1.497 g/sec, an angle of repose at 40.75o, compressibility of 11.45%, drying loss of 0.62%, and a foam height of 3.075 cm, consistently meeting the stipulated criteria. Furthermore, formula I, II, and III preserved L. acidophilus bacteria after being converted into effervescent granules, as evidenced by viable lactic acid bacteria counts, with formula I (412.5 x 101 cfu/g), formula II (422.7 x 101 cfu/g), and formula III (highest at 522.7 x 101 cfu/g). The formula I emerges as the most favorable effervescent granules containing L. acidophilus 3%; polyvinylpyrrolidone 3%; citric acid 0.3 %; tartaric acid 49.7%; sodium bicarbonate 25% and lactose as filler. Based on the finding, this probiotic effervescent granules has the potential to be developed as a daily supplement, especially for flora normal stabilization.
Pemanfaatan Sampah Rumah Tangga sebagai Media Vertikutur di Lingkungan Batumaali Kelurahan Baadia Kota Baubau
Authors: Slamet Agus , Andarias S. Hafidhawati , Isyana Ardhiati Dyah Pramesti , Tala Wd. Syarni
Published: November 2023

Masyarakat Lingkungan Batumaali Kelurahan Baadia Kota Baubau belum mengoptimalkan pemanfaatan sampah rumah tangga. Sampah berupa botol dan kemasan plastik dapat digunakan sebagai wadah bercocok tanam secara vertikultur. Vertikultur merupakan teknik budidaya tanaman (berupa sayur, tanaman hias maupun apotek hidup) secara bertingkat. Kegiatan pengabdian ini bertujuan untuk memberikan pelatihan dan pendampingan pengolahan sampah rumah tangga dan budidaya tanaman secara vertikultur kepada ibu rumah tangga. Metode yang dilakukan dalam kegiatan pengabdian ini berupa sosialisasi dan praktek. Hasil kegiatan pengabdian ini ditandai dengan meningkatnya pengetahuan, pemahaman dan keterampilan masyarakat tentang pengelolaan sampah plastik, pengolahan limbah dapur rumah tangga, dan budidaya tanaman secara vertikultur dengan memanfaatkan plastik bekas serta mampu menyiapkan  media tanaman, dan pupuk organic cair  (POC) untuk memacu pertumbuhan tanaman sayur & apotik hidup ramah lingkungan skala rumah tangga. Hasil post-test menunjukan adanya peningkatan pengetahuan sekitar 65 % dibandingkan sebelum pelatihan sehingga kegiatan pengabdian ini tergolong berhasil. Oleh karena itu, kegiatan ini relevan dengan kebutuhan masyarakat di lingkungan Batumaali.
Guidance for Students in The Development of Learning Media to Increase Learning Outcomes
Authors: Matje Irman
Published: November 2023

Overcoming the problem of low student learning outcomes is very important for the development of learning media so that students get good learning outcomes. Therefore, this study aims to determine the development of learning media to improve social studies learning outcomes. The population in this study were all students of class V as many as 22 students. The total value of the learning media development test on student learning outcomes is 0.81, in accordance with the findings of this study that the impact index value obtained is positive. The development of learning media has a significant effect on student learning outcomes. The development of learning media is considered successful if it is able to actively involve students in the learning process physically, mentally, and socially, as well as increase students' self-confidence.
Audio Visual Media Learning Guidance using Wondershare Filmora as Elementary School Teacher Professional Development in Batupoaro District Baubau City
Authors: Yusnan Muhammad , Aminu Nurmin
Published: November 2023

The field of Information Technology which is the basis of learning, in this case the basis of the Teacher Working Group is obliged to share about video editing procedures with Filmora. In addition, the existence of a Teacher Working Group organization in Batupoaro District is also a strong reason to help schools that have not yet received an understanding of the Wondershare Filmora software. The method used in this service activity is in the form of socialization and practice. Through training and guidance, it is hoped that the Teacher Working Group in Batupoaro District can make Wondershare Filmora software as a good learning medium to be applied in elementary schools. The results of this service activity are marked by increased knowledge, understanding and skills of the Teacher Working Group Batupoaro Cluster 2 Baubau City has: 1) a better understanding of multimedia, especially in terms of video editing, 2 becomes more aware of applicable information technology, 3) become more aware of the Wondershare Filmora software application in daily learning classes, 4) become more confident when entering the community with the knowledge they have
Pendampingan Penyusunan Materi Percakapan Bahasa Arab di Pondok Pesantren Al-Ishlah Paciran Lamongan Jawa Timur
Authors: Syukri Zarkasyi Azmi , Rofi'i Muhammad Arwani , Robi'aqolbi Rosydina , Rahmawati Fitra Awalia , Istiqomah Alma , Hazrah Andi
Published: November 2023

Sebagai sekolah menengah yang turut mengajarkan bahasa Arab dengan metode langsung kepada santrinya, metode dan bahan ajar bahasa Arab di pesantren sangat perlu dimutakhirkan. Hal ini dapat dilakukan melalui pemanfaatan MoU kerjasama antar perguruan tinggi yang ada di pesantren tersebut. Kerjasama kegiatan ini diwujudkan dalam bentuk Praktek Pengayaan Lapangan dengan fokus desain pembelajaran bahasa Arab. Pondok pesantren yang dituju, memiliki beberapa kesamaan fokus dengan visi dan misi program studi. Khususnya dalam hal desain bahan ajar. Kegiatan ini berlangsung selama 1 pekan. Hasilnya, realisasi kegiatan ini menghasilkan rekomendasi bahwa: 1) penyusunan bahan ajar harus mempertimbangkan aspek geografis dan jadwal keseharian pesantren. 2) bahan ajar harus mengandung terjemah dalam 2 bahasa: Indonesia dan Inggris. 3) pengajaran lebih efektif jika melibatkan pengurus pondok dari santri.
Culture-Based Character Education Communications in Bukit Wolio Indah
Authors: Safiuddin
Published: November 2023

The development of culture-based character-based education needs to be a regional program, especially for the people of Bukit Wolio Indah Village. In developing culture-based character communication, it has not been fully maximized so that the development of culture-based character education in Bukit Wolio Indah Village in the spiritual, emotional and intellectual fields has not been so balanced and harmonious. In addition, there are many teenagers and young people who apparently do not know or are not familiar with the existing culture-based character education and it turns out that it contains noble character values. The method of this service activity is a descriptive qualitative study method. This method is the result of the author's ideas which are then developed based on theories that are in accordance with the discussion. The results of this service explain that the process of character building based on culture has been able to instill values that are grown and developed in the form of basic cultural values. These values include honesty, trustworthiness, togetherness, tolerance, responsibility, and caring for others.
Fostering the Attitude of Tolerance Between Religious Comunity at The Al-Amin Mosque at the Resort Police of Baubau
Authors: Samsu La
Published: November 2023

Religious tolerance is a relationship between religious communities based on mutual acceptance, mutual respect, respect for every difference, respect for equality in the practice of their religious teachings and work together in the life of society, nation and state. Tolerance actually develops within the framework of the existence of diversity in various dimensions of life, so that harmony and harmony in life can be realized, far from conflicts and social tensions, especially conflicts and hostility among each other in society. The method used during the activity was various lectures to provide understanding and convey theoretical concepts in order to help the congregation understand the nature of inter-religious tolerance at the Baubau Police Resort Al-Amin Mosque. The results of this service foster an attitude of tolerance in religious diversity that can be properly embedded because of the attitude of tolerance in society. The role of leaders and community leaders is very important in instilling an attitude of religious tolerance both through giving examples and through sustainable activities.
Making Boundaries and Site Plans in Nambo Village, Lasalimu District, Buton Regency
Authors: Sayfullah Muh , Idwan Idwan , Efendi Ahmad , Agusman Agusman , Aldha Sitti Febriyany
Published: November 2023

Buton Regency is a Level II region in the Indonesian province of Southeast Sulawesi. Nambo Village is comprised of three hamlets: Nambo, Lagonturu, and Tandaompure. It has an area of 25.5 kilometers. When it comes to carrying out operations, both government and community social, the people of Nambo community constantly promote mutual collaboration. The Village Government and Karangtaruna both have programs for planning and designing village boundaries and site plans, however relevant parties lack the skills or knowledge to participate in the planning and design process. The debate outcomes resulted in the design of the Nambo village border and site layout, as well as the materials to be utilized in the village boundary construction process. To enhance the look of the border, mountain stone foundations, brick walls, and natural stone are employed
Training on The Utilization of Mendeley and Similarity in Increasing The Quality of Students’ Academic Work
Authors: Ayuni Rossa , Meirani Meirani
Published: November 2023

Undergraduate  students (S1)  who complete their studies are required to be able to write not only a final project in the form of a thesis, but also a scientific pa-per in the form of scientific articles. However, the issue is that students view writing research reports as a very tiresome task, whether it's making quota-tions, creating lists, or many prefer a fast flow such as copy paste. As a result, this training activity is predicted to be beneficial for students in terms of writ-ing research results and the outcomes of their studies in the form of scientific papers, as well as enhancing the quality of scientific articles for students, par-ticularly in the field of education. The instructional approach is a combination of lecture, question and answer, simulation, and practice.
Educational Game Tool Flash Card Hijaiyyah Letter as A Medium of Stimulation of The Development of Moral and Religious Values of Children In TK Al Gazali Desa Metere Lakudo Subdistrict
Authors: Risman Kadar , Saleh Rachman , Selvi Selvi
Published: November 2023

The community service project that we conducted on October 30, 2021 at TK Al Gazali Desa Metere District Lakudo Central Buton District aims to provide teachers with insight into effective media for learning in Early Childhood, to improve teacher skills in creating educational game tools, and to provide teachers with insights and equip them to develop learning media in the form of Educational Game Tools for Children in their Early Age. Teachers at Al Gazali Kindergarten in Metere Village, Lakudo District, Central Buton Regency were the intended recipients of this activity. The topic of dedication concerns the instructors' degree of awareness and ability, as well as the limitations of educational gaming instruments that can help pupils at Al Gazali Kindergarten in Metere Village acquire moral and religious values. Three phases are necessary to resolve the problem: preparation, implementation, and assessment. The planning stage begins with observations to ascertain the state of educational gaming instruments in use at the school. The implementation stage is comprised of training in the creation of Hijaiyyah Letter Flash Cards, beginning with the delivery of material in the form of perentase via lecture methods, followed by Q&A or discussion and training in the form of a workshop in the creation of APE Flash Cards Hijaiyyah Letter as a means of improving teacher skills. Monitoring and assessment concludes the process. Monitoring and evaluation are accomplished by the collection and analysis of data at each level. The training results indicated a degree of success, with kindergarten teachers Al Gazali Desa Metere gaining a better understanding of the importance of APE in stimulating the development of moral and religious values, teachers improving their skills in creating APE Flash Cards to aid in the learning process, teachers responding positively to the training conducted, and teachers successfully completing the creation of APE Flash Card Hijaiyyah, according to the number.
Developing Student Motivation Through Scientific Writing Learning Guidance
Authors: Nur Intan Ode Muhamad , Suherman La Ode Achmad
Published: November 2023

In this community service project, tutoring will be highlighted. Tutoring is used in this activity to provide students with a range of perspectives on the knowledge they have learned as a consequence of their own experiences with their surroundings. Students contribute significantly to the development of thinking abilities through their use of language in scientific papers. The approaches used in this service activity include explanation and practice. This is because students' understanding and writing abilities are limited, making it harder for them to produce scientific articles. One aspect of student development is the development of the capacity to write scientific articles. This capability is immediately obvious in well-structured writing. The findings of this study show that students were able to write scientific papers as a consequence of this service, allowing them to grow and think creatively while finishing their studies through the production of scientific papers, and that students are proficient at writing scientific papers.
Lise Öğrencilerinin Akran Zorbalığına Yönelik Algılarının Metafor Analizi Yöntemiyle Değerlendirilmesi
Authors: Şardağ Hasan , Bahadır Yılmaz Emel
Published: November 2023

Amaç: Bu çalışma, lise öğrencilerinin akran zorbalığı hakkındaki algılarını metafor analizi yoluyla değerlendirmeyi amaçlamaktadır.
Yöntem: Fenomenolojik tasarımdaki bu araştırmanın evrenini, Doğu Karadeniz’de bir devlet lisesinde eğitim öğretime devam eden öğrenciler oluşturmuştur. Araştırmanın örneklemi ise 21 öğrenci oluşturmuştur. Çalışmada öğrencilere kişisel bilgi formu ile akran zorbalığı hakkındaki metaforlarını öğrenmek için bir form kullanılmıştır. Tanımlayıcı verilerin değerlendirilmesinde sayı, yüzde, ortalama ve standart sapma değerleri verilmiştir.
Bulgular: Öğrencilerin %46.6’sı fiziksel zorbalığa, % 57.1’i sözel zorbalığa ve %52.5’i psikolojik/duygusal zorbalığa maruz kaldıklarını bildirmiştir. Yapılan metafor analizinde üç ana tema elde edilmiştir: 1) Mağdur kişinin duyguları (çaresizlik, utangaçlık, değersizlik, korku ve üzüntü), 2) Mağdur kişinin sosyal yaşamı (sosyalleşememe, hayattan soğuma, arkadaşlık kuramama ve etkinliklerden uzaklaşma) ve 3) Mağduriyete karşı koyma (zorba olma, içine kapanma, ne yapacağını bilememe ve psikolojik sorunlar yaşama).
Sonuç: Lise çağında karşılaşılan zorbalık davranışı kişinin gelişimini olumsuz yönde etkilemekte ve gelecek yaşanışında özgüveni düşük, kendini ifade edemeyen, sosyal ilişki kurmak istemeyen kişilerin ortaya çıkmasına sebep olmaktadır. Bu sonuçlar doğrultusunda, vakaları okul yönetimine bildirme ve psikolojik destek verme, ben dili kullanma ve sağlıklı iletişim kurma, hayır deme becerisi, atılganlık ve problem çözme becerisi gibi problem çözümleyici beceri eğitimleri düzenleme önerilmiştir.
MIR-145's Regulatory Role in Breast Cancer Progression
Authors: Dinçer Boran Can
Published: November 2023

Delayed diagnosis of breast cancer results in lower treatment success rates and lower survival rates. Every year millions of women are diagnosed with breast cancer and many of them die from this disease. However, the discovery of biomarkers that enable early diagnosis should increase the success of treatment processes and extend survival times. In recent years, studies have been carried out to use microRNAs as biomarkers in the early detection of breast cancer. Research shows that microRNAs can serve as potential biomarkers for the diagnosis and prognosis of breast cancer. In addition to ongoing research on the possible use of microRNAs as biomarkers for early breast cancer diagnosis, our study also analyzed the possible use of miR-145 as a biomarker in breast cancer. In our study, RNA samples were isolated from blood serum samples of 200 breast cancer patients and 100 people in the healthy control group, and the specific expression levels of miR-145 were determined using RT-qPCR technique. As a result of these analyses, it was found that miR-145 had lower expression levels in breast cancer patients than in healthy controls. After further investigation of the biomarker potential of miR-145 in a larger group of breast cancer patients, it will be used as a target biomarker for early breast cancer diagnosis.
Parmak İzi Kaybına Neden Olan Kanser İlaçlarına Genel Bakış
Authors: Öğretici Oral Sara , Dere Egemen
Published: November 2023

Amaç: Günümüzde kanser; cerrahi yöntemler, kemoterapi, radyoterapi, kemik iliği, kök hücre nakli, immünoterapi, hormon ve antikor tedavisi gibi yöntemler kullanılarak tedavi edilmeye çalışılmaktadır. Her yöntemin kendi içinde avantaj ve dezavantajları vardır. Kemoterapide kullanılan ilaçların meydana getirdiği yan etkilerden birisi de hastalarda el ve ayaklarda kızarıklık, şişme, kaşıntı ve hissisleşmeye neden olmasıdır. Özellikle bu yan etki sürecinde parmak izlerinin kaybolması kriminal açıdan önemli sorunlara neden olmaktadır. Bu çalışmada el ayak sendromuna neden olan kanser ilaçları incelenmiş ve etkileri açıklanmaya çalışılmıştır.
Yöntem: Farklı veri tabanları üzerinden makaleler, elektronik kitaplar, dergiler, tezler incelenmiştir.
Bulgular ve Sonuç: Çalışmada kemoterapide kullanılan ilaçlardan palmar ve plantar bölgelerde kızarıklıklara neden olan el ve ayaklarda yanma, hissislik meydana getiren ilaç etkin maddeleri tablolar halinde sunulmuştur. Bu maddeler arasında başta kapesitabin olmak üzere, kabozantinib, pazopanib, vemurafenib, aksitinib, doksorubisin, sunitinib, regorafenib, dosetaksel ve sorafenib gibi maddeler bulunmaktadır. El ayak sendromuna neden olan metabolik yol hala açıklanmamıştır.
Book Review: Working Backwards
Authors: Wagen Corin
Published: November 2023

I took a pistol course in undergrad, and while I was a poor marksman I enjoyed the experience. In particular, I was surprised by how meditative the act of shooting was. As our instructor explained, much of good shooting comes down to not doing anything when you pull the trigger.
Felix Falk, Unterhaltungssoftware Selbstkontrolle: „Ich halte nichts von Netzsperren“
Authors: Steinhau Henry
Published: November 2023

Felix Falk ist Geschäftsführer der Unterhaltungssoftware Selbstkontrolle (USK), einer freiwilligen Einrichtung der Computerspiele-Wirtschaft. Die USK gehört zu den Einrichtungen, die direkt in die geplanten Prozesse zur Alterskennzeichnung von Online-Inhalten eingebunden sein soll, sofern es zu der geplanten Änderung des Jugendmedienschutz-Staatsvertrages kommt.
Schweizer Regierung: Massenabmahnungen und Netzsperren für ein „sauberes Internet“
Authors: Steiger Martin
Published: November 2023

Die Schweizer Regierung, der Bundesrat, hat Pläne für Änderungen im Urheberrecht bekannt gegeben. Zwar wird es bis zu einer konkreten Gesetzesvorlage noch länger dauern, die ersten Ankündigungen aber haben es in sich: Von Provider-Sperren über Warnhinweise bis hin zu Haftungsregeln tragen sie einseitig die Handschrift der Unterhaltungs­industrie, kommentiert Martin Steiger.
EuGH entscheidet gegen diskriminierende Parodien, Haftung für Facebook-Fanpage, Störerhaftung bei Sicherheitslücke
Authors:   telemedicus.info
Published: November 2023

Urheber müssen diskriminierende Parodien nicht dulden, Datenschützer scheitern erneut damit, Fanpage-Betreiber für Facebooks Datenverarbeitung haftbar zu machen. Außerdem im Wochenrückblick: Urteil zur Störerhaftung bei Router-Sicherheitslücke, „bag.de“-Domainstreit, Gysi-Akten und Haftung beim Online-Banking.
Allwissende Händler, genügsame Datenschützer
Authors: Schulzki-Haddouti Christiane
Published: November 2023

Rund um das Einkaufen ist ein datenintensives System entstan­den: Händler, Auskunfteien und andere Unternehmen sammeln zahlreiche Daten, um Kunden möglichst individuell anzusprechen, die Zahlungsfähigkeit zu bewerten und Kundenprofile zu erstellen. Für den Kunden aber bleibt undurchschaubar, wo und wie er ein­geordnet und bewertet wird. Datenschutz-Aufsichtsbehörden zeigen sich bei vielen Fragen nicht nur zahn-, sondern willenlos.
Bundestag richtet NSA-Untersuchungsausschuss ein, Netzneutralität, Non-commercial-Lizenzen
Authors:   telemedicus.info
Published: November 2023

Der Bundestag beschließt, die Aktivitäten von NSA & Co. zu untersuchen, der Industrieausschuss im EU-Parlament votiert zur Netzneutralität, das Landgericht Köln sieht das Deutschlandradio als kommerziellen Creative-Commons-Nutzer. Außerdem im Wochenrückblick: Jugendmedienschutz, Bundesregierung zu Redtube, Twitter-Sperre in der Türkei.
Wie funktioniert Dating nach Zahlen?
Authors: Klette Kathrin
Published: November 2023

Wie viele Informationen sind nötig, damit aus zwei Singles ein Paar wird? Ein Gründer der Dating-Plattform OkCupid hielt einmal die Antworten auf drei Fragen für ausreichend. Doch die Plattformen setzen heute komplexere Matching-Algorithmen ein. Manch ein Nutzer überlistet sogar die Systeme und erprobt eigene Methoden im Datenwust.
Lawrence Lessig: Wenn wir Remix kriminalisieren, schaden wir der Kreativität
Authors: Lessig Lawrence
Published: November 2023

Schon 2008 hat Lawrence Lessig, Rechtswissenschaftler und Copyright-Aktivist, in seinem Buch „Remix“ auf die Folgen hingewiesen, die eine immer restriktivere Copyright-Gesetzgebung auf die Kreativität hat. Die Einleitung von „Remix“ ist ein wortstarkes Plädoyer dafür, Künstlern die Freiheit zu lassen, mit den sie umgebenden Werken neue Kunst zu machen.  Die Einleitung von „Remix. 
EU-Länder wollen dem WIPO-Blindenvertrag beitreten
Authors: Steinhau Henry
Published: November 2023

Wie Heise Online berichtet, wollen die EU-Mitgliedstaaten neun Monate nach Verabschiedung des „Blindenvertrags“ der Welturheberrechtsorganisation WIPO die internationale Übereinkunft unterzeichnen. Der Ausschuss der Ständigen Vertreter der EU-Mitgliedstaaten hat demnach vergangene Woche den Beitritt auf den Weg gebracht. Die nun noch notwendige Einigung der Regierungsvertreter im Rahmen einer Plenarsitzung des EU-Rates gelte als Formsache.
Mixe erlaubt: Britische Musiker erteilen DJs Soundcloud-Erlaubnis
Authors: Steinhau Henry
Published: November 2023

Das könnte Schule machen: Aus Ärger über Sperrungen bei Soundcloud verfassen britische Musiker eine Blanko-Erlaubnis, die DJs erlaubt, Mixe bei Soundcloud hochzuladen. Mit einem knappen Facebook-Post weist die britische Band „Blu Mar Ten“ und ihr Label „Blu Mar Ten Music“ auf eine Blanko-Erlaubnis für DJs hin.
Netflix in Deutschland: Durch den Rechtedschungel – und um ihn herum
Authors: Weiß Marcel
Published: November 2023

Vorgestern startete das US-amerikanische Unternehmen Netflix seinen gleichnamigen Videostreaming-Dienst auch in Deutschland. Auf den ersten Blick ist es ein weiterer Wettbewerber auf dem Online-Video-Markt und um Film- und Serienrechte.
„Digitale Agenda“ der Bundesregierung, Frust über EU-Urheberrecht, „Google-Steuer“ in Spanien
Authors:   telemedicus.info
Published: November 2023

Ein erster Entwurf der „Digitalen Agenda“ der Bundesregierung wird bekannt, Bundesdatenschützerin Voßhoff äußert verfassungsrechtliche Bedenken zur Anti-Terror-Datei, Hamburg verbietet den Fahrdienst „Uber Pop“. Außerdem im Wochenrückblick: Bericht zur EU-Urheberrechtskonsultation vorgestellt, Russland will Tor-Nutzer enttarnen, neues Urheberrecht und „Google-Steuer“ in Spanien.
Löschansprüche: Das Problem zuerst dort angehen, wo es entsteht
Authors: Kreutzer Till
Published: November 2023

Neben dem fehlenden Gleichgewicht zwischen Persönlichkeitsrechten und Kommunikationsfreiheiten weist Verfassungsrichter Johannes Masing auf ein weiteres Problem des EuGH-Urteils zum „Recht auf Vergessenwerden“ hin: Wenn Suchmaschinen Verweise löschen, wird das Problem vom eigentlichen Konflikt entkoppelt. Zugleich macht er einen sinnvollen Alternativvorschlag.
Entweder-oder-Typen, Crowdsourcing und Schatten-Archive: 12 Vorträge und Gespräche von der re:publica
Authors: Pachali David
Published: November 2023

Die re:publica-Konferenz ist vorbei, mittlerweile stehen 185 Mitschnitte von Talks sowie Interviews zum Binge-Watching online. Neben den bereits vielverlinkten Vorträgen und Präsentationen – etwa zur ernsten Lage der Nation oder unterhaltsamen neuen Google-Produkten – hier eine Auswahl von 12 sehenswerten Videos zu den Themenbereichen kreatives Schaffen, Urheberrecht, Datenschutz und Regulierung im Netz.
US-Gericht beharrt auf staatlichem Zugriff auf Server im Ausland
Authors: Steinhau Henry
Published: November 2023

Das Unternehmen Microsoft soll dazu verpflichtet werden, ermittelnden US-Behörden auch solche Daten unmittelbar herauszugeben, die auf Servern im Ausland gespeichert sind. Wie unter anderem die Seattle Times und die Washington Post berichten, entschied die New Yorker Richterin Loretta Preska, dass Microsoft dazu verpflichtet sei, ermittelnden US-Behörden Zugriff auch auf Nutzerdaten zu geben, die sich auf Servern im Ausland befinden.
Neue Vorschläge – alter Streit: „Wissenschaftsschranke“ in der Diskussion
Authors: Steinhau Henry
Published: November 2023

Mit ihrer Studie über eine „allgemeine Bildungs- und Wissenschaftsschranke“ hat die Berliner Rechtsprofessorin Katharina de la Durantaye einer lange währenden Debatte neue Impulse gegeben. Bei einer Konferenz zur Vorstellung der Studie gehen Befürworter und Kritiker auf die konkreten Reformvorschläge ein.
Soundcloud verärgert mit Sperrungen und Kurswechsel seine Nutzer
Authors: Steinhau Henry
Published: November 2023

Die Musik-Plattform Soundcloud steht in der Kritik. Diesmal geht es nicht nur um die Sperrung von Musikstücken, sondern ganzer Nutzer-Konten durch den Musikkonzern Universal. Dahinter steht eine langsame, aber tiefgreifende Wandlung: Aus der Community-Plattform für Musik-Newcomer und DJs könnte eine Vermarktungsmaschine für globale Musikunternehmen werden.
Leistungsschutzrecht: T-Online und 1&1 verbannen Verlage der VG Media aus ihren Suchergebnissen
Authors: Steinhau Henry
Published: November 2023

Das Leistungsschutzrecht für Presseverlage zeigt offenbar erste Wirkungen. Wie der Medienjournalist Stefan Niggemeier gestern auf seinem Blog berichtet, nutzen die Internetunternehmen 1&1 und T-Online auf ihren Seiten die Angebote jener Verlage nicht mehr, die Ansprüche aus dem Leistungsschutzrecht für Presseverlage geltend machen.
iRights singt ein Ständchen
Authors: iRights.info Redaktion
Published: November 2023

Remix im Alltag: Wikimedia Deutschland wird 10 Jahre alt. Und iRights will mit einem Lied gratulieren. Kein Problem? Denkste. Freitag, 10 Uhr, Teamsitzung im Raum Snowcrash des iRights-Headquarter. Tagesordnungspunkt: Termine. Der Deutsche Juristentag diskutiert übers Urheberrecht, Netflix kommt, die EU-Kommission benennt neue KommissarInnen. So weit, so alltäglich. Aber: Wikimedia Deutschland wird 10. Da muss man doch was machen!