bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships between Individual and Social Resources, Anxiety and Depression in the Early Lockdown Stage by the COVID-19 in Chile
Authors: Salgado Sergio , González-Suhr Carolina , Nazar Gabriela , Alcover Carlos-María , Ramírez-Vielma Raúl , Bustos Claudio
Published: September 2022

The coronavirus disease has exposed the population to psychosocial threats that could increase mental health problems. This research analyzed the relationships between emotional states (negative [−EWB] and positive [+EWB] experienced well-being), personal resources (resilient coping [RC]), dispositional resources (control beliefs about stress [BAS]), and social resources (social support [SS]), and anxiety and depressive symptoms in a sample of the Chilean population (n = 592), who answered an online questionnaire. Multiple and moderated multiple regression analyses were carried out. Depressive symptoms showed a positive relationship with −EWB (β = 0.805; p < 0.001) and negative relationship with +EWB (β = −0.312; p < 0.001), RC (β = −0.089; p < 0.01), BAS (β = −0.183; p < 0.001) and SS (β = −0.082; p < 0.001). Anxiety symptoms showed a positive relationship with −EWB (β = 0.568; p < 0.001), and a negative relationship with +EWB (β = −0.101; p < 0.03) and BAS (β = −0.092; p < 0.001). BAS moderated the relationship between experienced well-being and depression symptoms, and RC moderated the relationship between experienced well-being with both depression and anxiety symptoms. Findings confirm the buffering effect of personal and dispositional resources when facing a sanitary and social crisis. Moreover, they help to understand the role of internal psychological processes during a crisis and how to cope with life-threatening events.
A Scientometric Review of Management of Prefabricated Construction from 2011–2021
Authors: Li Clyde Zhengdao , Li Shanyang , Li Xiao , Wu Hengqin , Xiao Bing , Tam Vivian W. Y. , Asiedu-Kwakyewa Cornelia
Published: September 2022

Prefabricated construction (PC) is an increasingly popular method of construction utilized globally due to its high productivity and efficient performance. PC as an advanced building technique is susceptible to problems such as the immaturity of the PC industry’s development, inability to realize production benefits, and application-related risks and uncertainties. The management of PC (MPC) can be applied to resolve these difficulties and generally enhance performance. Reviews pertinent to the MPC are scarce, making it challenging to concentrate and comprehensively summarize the research situation of the MPC. The MPC review was conducted by Li et al. in 2014. However, there has been a lot of change in the MPC research field. Therefore, this study is an extension of the work of Li et al. (2014). This article aims to analyze and summarize the current research situation and future trends of the MPC, employing a bibliometric search and scientometric analysis from MPC-related publications between 2011 and 2021. This paper outlines current research topics, gaps, and future development from four perspectives based on publications gathered: (1) PC development, (2) PC performance management, (3) PC life cycle management, and (4) technological applications in the MPC. Based on the discussion of these four performance indexes, the following future research directions are proposed: (1) PC industry development considering a combination of Industry–University–Research, (2) the performance impact of management methods and technologies, (3) the rationality of management methods and technologies. This study is vital for scholars to understand MPC research and to conduct further research.
Effects of Acoustic Perception on Outdoor Thermal Comfort in Campus Open Spaces in China’s Cold Region
Authors: Chen Huiying , Hong Bo , Qu Hongyun , Geng Yubo , Su Meifang
Published: September 2022

To explore the effects of acoustic perception on outdoor thermal comfort, acoustic perception in five typical open spaces in a campus in China’s cold region with common soundscapes was evaluated by using meteorological measures, sound level devices, and a questionnaire survey. Eight adjectives were used to evaluate an individual’s acoustic perception, and the physiological equivalent temperature (PET) was selected as a thermal index. The correlations between acoustic perception and thermal comfort in these typical open spaces were further analyzed. We demonstrated that: (1) Acoustic sensation and comfort varied significantly among sound types (STPs). Respondents reported pleasant perceptions of broadcasting music, running water and birdsong, and wind (a gentle breeze) and insects. (2) Although there was no significant difference in the thermal sensation vote (TSV), we found large differences in the thermal comfort vote (TCV) among STPs. (3) The respondents’ neutral PET (NPET) varied among STPs. In autumn, the ranked order of NPET was machines > running water and birdsong > crowds > broadcasting music > wind (a gentle breeze) and insects. In winter, the order of the NPET was machines > wind (a gentle breeze) and insects > crowds > broadcasting music > running water and birdsong. (4) When people perceived “acoustic comfort”, their TSV improved, and vice versa.
Study on the Mechanical Response Mechanism and Damage Behavior of a Tunnel Lining Structure under Reverse Fault Dislocation
Authors: Su Huifeng , Zhao Zhongxiao , Meng Kun , Zhao Shuo
Published: September 2022

In this paper, the mechanical response mechanism and damage behavior of a railway tunnel lining structure under reverse fault dislocation were studied. The damage behavior of railway tunnel linings under reverse fault dislocation was validated by undertaking laboratory tests and three-dimensional numerical simulations, where Coulomb’s friction was used in the tangential direction of the interface. The failure damage, which increasingly accumulates with displacements, mainly concentrates in fault fracture neighborhoods 0.5 D to 1.5 D (D is the tunnel diameter) within the footwall. The maximum surrounding rock pressure and the maximum longitudinal strain develop in the tunnel near the hanging wall area. The damage begins as longitudinal cracking of the inverted arch. With the increase in dislocations, those cracks develop upward to the arch foot and the waist. Consequently, those oblique cracks separate lining segments, leading to abutment dislocation. The research results provide technical guidance and theoretical support for on-site construction and follow-up research, and they have important application value.
Design Optimisation of a Cable–Strut Tensile Structure According to the Importance of Elements
Authors: Chen Lian-Meng , Li Ze-Bin , Zhang He , Liu Yi-Jie , Zeng Yi-Hong , Zhou Yi-Yi , Dong Shi-Lin
Published: September 2022

In this study, the design of a flexible cable–strut tensile structure was optimised according to the importance of elements to achieve high structural robustness. First, the importance coefficients of elements were determined by comparing their structural prefailure and postfailure strain energy. Moreover, the effects of the external load, the initial prestress, and the cross-sectional areas of elements on the importance coefficients were analysed. Second, a genetic algorithm was used to optimise element section design and minimise the maximum importance coefficient. Third, an optimised cable arrangement scheme was developed by adding an alternative load transfer path to the outer hoop cable with the highest importance coefficient. In this scheme, outer elements have a Levy-type arrangement rather than a Geiger-type arrangement so that a Geiger–Levy composite cable dome is formed. Finally, the cable arrangement and element section design for the aforementioned scheme were comprehensively optimised to reduce the maximum importance coefficient. The results of this study indicated that different elements had different importance coefficients, which exhibited different trends with changes in the external load, the initial prestress, and the cross-sectional areas of elements. Element section optimisation, cable arrangement optimisation, and the comprehensive optimisation reduced the maximum importance coefficient by 20.5%, 11.6%, and 27.7%, respectively, which indicated that these optimisation processes can effectively improve the robustness of cable–strut tensile structures.
Selection of Ground Motion Intensity Measures in Fragility Analysis of a Mega-Scale Steel Frame Structure at Separate Limit States: A Case Study
Authors: Zhang Yantai , Shen Ruihan , Sun Baoyin , Liu Tingting , Shi Yongan , Li Luyao
Published: September 2022

Selecting an appropriate ground motion intensity measure (IM) to estimate the aleatory uncertainty produced by ground motion variability is the first and crucial step in fragility analysis. The choice of IM is influenced not only by the structural system type itself but also by the limit state of the structural damage. In this study, an investigation of the selection of IM in fragility analysis with respect to different limit states is developed for a 48-story mega-scale steel frame structure with buckling restrained braces. A comparative study of the efficiency of 27 IMs is conducted at four structural damage limit states, i.e., negligible, light, moderate, and severe, through the lognormal standard deviation estimated in fragility equations. In addition, for the purpose of considering the influence of different earthquake characteristics, two completely different sets of ground motions are selected, namely near-field pulse-like and far-field earthquakes. The research shows that the ground motion characteristics and structural damage limit states have nonnegligible effects on the flexibility of intensity measures. For combination-type IMs, the number of combined terms and the combined power index have a significant impact on their performance; thus, an optimized dual-parameter combination-type intensity measure is recommended.
Zinc–Acetate–Amine Complexes as Precursors to ZnO and the Effect of the Amine on Nanoparticle Morphology, Size, and Photocatalytic Activity
Authors: Harris Jerry D. , Wade Emily A. , Ellison Emmaline G. , Pena Cecelia C. , Bryant Stephen C. , McKibben Nicholas L. , Christy Allison J. , Laughlin Kevin O. , Harris Ashley E. , Goettsche Kenrik V. , Larson Chad E. , Hubbard Seth M. , Cowen Jonathan E. , Eixenberger Josh , Estrada David , Chase Jennifer R.
Published: September 2022

Zinc oxide is an environmentally friendly and readily synthesized semiconductor with many industrial applications. ZnO powders were prepared by alkali precipitation using different [Zn(acetate)2(amine)x] compounds to alter the particle size and aspect ratio. Slow precipitations from 95 °C solutions produced micron-scale particles with morphologies of hexagonal plates, rods, and needles, depending on the precursor used. Powders prepared at 65 °C with rapid precipitation yielded particles with minimal morphology differences, but particle size was dependent on the precursor used. The smallest particles were produced using precursors that yielded crystals with low aspect ratios during high-temperature synthesis. Particles produced during rapid synthesis had sizes ranging from 21–45 nm. The materials were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, thermogravimetric analysis, BET, and diffuse reflectance. The materials prepared using precursors with less-volatile amines were found to retain more organic material than ZnO produced using precursors with more volatile amines. The amount of organic material associated with the nanoparticles influenced the photocatalytic activity of the ZnO, with powders containing less organic material producing faster rate constants for the decolorizing of malachite green solutions under ultraviolet illumination, independent of particle size. [Zn(acetate)2(hydrazine)2] produced ZnO with the fastest rate constant and was recycled five times for dye degradation studies that revealed minimal to no reduction in catalytic efficiency.
Heteropolyacid Incorporated Bifunctional Core-Shell Catalysts for Dimethyl Ether Synthesis from Carbon Dioxide/Syngas
Authors: Karaman Birce Pekmezci , Oktar Nuray , Doğu Gülşen , Dogu Timur
Published: September 2022

Core-shell-type catalysts, which are synthesized by encapsulating the Cu-ZnO-Alumina type methanol synthesis catalyst (CZA) by silicotungstic acid (STA)-incorporated mesoporous alumina, were prepared following a hydrothermal route and tested in DME synthesis from syngas and CO2. Activity tests, which were performed in the pressure range of 30–50 bar, and the temperature range of 200–300 °C, with different feed compositions (CO2/CO/H2: 50/-/50, 40/10/50, 25/25/50, 10/40/50) showed that the best-operating conditions for the highest DME yield were 275 °C and 50 bar. Results proved that the presence of CO2 in the syngas had a positive effect on the DME yield. The total conversion of CO + CO2 increased with an increase in CO2/CO ratio. An overall conversion of CO + CO2 and DME selectivity values were obtained as 65.6% and 73.2%, respectively, with a feed composition of H2/CO2/CO = 50/40/10. Synthesis of methanol using the CZA catalyst from the CO2-containing gas mixtures was also investigated, and the total conversion of CO + CO2 and methanol selectivity values of 32.0% and 83.6%, respectively, were obtained with the H2/CO2/CO = 50/40/10 gas mixture. Results proved that the new STA incorporated core-shell-type bifunctional catalysts were highly promising for the conversion of CO2-containing syngas to DME.
Research on Modified Carbon Nanotubes in Wastewater Treatment
Authors: Li Ming , Jia Xiang , Wang Liang , Gao Guangyao , Feng Xuefu , Li Chenyang
Published: September 2022

The application of modified carbon nanotubes (MCNTs) in the field of wastewater treatment has received much attention in recent years. To better understand the research progress and trends of MCNTs in wastewater treatment, this paper presents a bibliometric analysis of the scientific literature on the application of MCNTs in wastewater, highlight how it has evolved over the years, and identify the sectors for which the study could be beneficial. The CiteSpace software was used to perform the analysis of the data in which specific maps were used to represent the network of the relationships among countries, journals, organizations, authors, and keywords related to the investigated topic and subtopics. The results show that in the time frame of the study, most attention has been focused on the functional modification of carbon nanotubes, the study of their application in water treatment, and the study of the patterns and mechanisms of pollutant removal. The recycling of MCNTs and their environmental risks have not been sufficiently studied. In conclusion, the recycling and regeneration methods of MCNTs, as well as the potential ecological, environmental and health risks will be the focus of future research and more research should be invested.
Towards High CO2 Conversions Using Cu/Zn Catalysts Supported on Aluminum Fumarate Metal-Organic Framework for Methanol Synthesis
Authors: Duma Zama G. , Moma John , Langmi Henrietta W. , Louis Benoit , Parkhomenko Ksenia , Musyoka Nicholas M.
Published: September 2022

Green methanol is a viable alternative for the storage of hydrogen and may be produced from captured anthropogenic sources of carbon dioxide. The latter was hydrogenated over Cu-ZnO catalysts supported on an aluminum fumarate metal-organic framework (AlFum MOF). The catalysts, prepared via slurry phase impregnation, were assessed for thermocatalytic hydrogenation of CO2 to methanol. PXRD, FTIR, and SBET exhibited a decrease in crystallinity of the AlFum MOF support after impregnation with Cu-Zn active sites. SEM, SEM-EDS, and TEM revealed that the morphology of the support is preserved after metal loading, where H2-TPR confirmed the presence of active sites for hydrogen uptake. The catalysts exhibited good activity, with a doubling in Cu and Zn loading over the AlFum MOF, resulting in a 4-fold increase in CO2 conversions from 10.8% to 45.6% and an increase in methanol productivity from 34.4 to 56.5 gMeOH/Kgcat/h. The catalysts exhibited comparatively high CO selectivity and high yields of H2O, thereby favoring the reverse water-gas shift reaction. The selectivity of the catalysts towards methanol was found to be 12.9% and 6.9%. The performance of the catalyst supported on AlFum MOF further highlights the potential use of MOFs as supports in the heterogeneous thermocatalytic conversion of CO2 to value-added products.
Stage-Dependent Activity and Pro-Chondrogenic Function of PI3K/AKT during Cartilage Neogenesis from Mesenchymal Stromal Cells
Authors: Klampfleuthner Felicia A. M. , Lotz Benedict , Renkawitz Tobias , Richter Wiltrud , Diederichs Solvig
Published: September 2022

Differentiating mesenchymal stromal cells (MSCs) into articular chondrocytes (ACs) for application in clinical cartilage regeneration requires a profound understanding of signaling pathways regulating stem cell chondrogenesis and hypertrophic degeneration. Classifying endochondral signals into drivers of chondrogenic speed versus hypertrophy, we here focused on insulin/insulin-like growth factor 1 (IGF1)-induced phosphoinositide 3-kinase (PI3K)/AKT signaling. Aware of its proliferative function during early but not late MSC chondrogenesis, we aimed to unravel the late pro-chondrogenic versus pro-hypertrophic PI3K/AKT role. PI3K/AKT activity in human MSC and AC chondrogenic 3D cultures was assessed via Western blot detection of phosphorylated AKT. The effects of PI3K inhibition with LY294002 on chondrogenesis and hypertrophy were assessed via histology, qPCR, the quantification of proteoglycans, and alkaline phosphatase activity. Being repressed by ACs, PI3K/AKT activity transiently rose in differentiating MSCs independent of TGFβ or endogenous BMP/WNT activity and climaxed around day 21. PI3K/AKT inhibition from day 21 on equally reduced chondrocyte and hypertrophy markers. Proving important for TGFβ-induced SMAD2 phosphorylation and SOX9 accumulation, PI3K/AKT activity was here identified as a required stage-dependent driver of chondrogenic speed but not of hypertrophy. Thus, future attempts to improve MSC chondrogenesis will depend on the adequate stimulation and upregulation of PI3K/AKT activity to generate high-quality cartilage from human MSCs.
PCSK9 Inhibition: From Current Advances to Evolving Future
Authors: Liu Chunping , Chen Jing , Chen Huiqi , Zhang Tong , He Dongyue , Luo Qiyuan , Chi Jiaxin , Hong Zebin , Liao Yizhong , Zhang Shihui , Wu Qizhe , Cen Huan , Chen Guangzhong , Li Jinxin , Wang Lei
Published: September 2022

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine protease synthesized primarily by the liver. It mainly promotes the degradation of low-density lipoprotein receptor (LDL-R) by binding LDL-R, reducing low-density lipoprotein cholesterol (LDL-C) clearance. In addition to regulating LDL-R, PCSK9 inhibitors can also bind Toll-like receptors (TLRs), scavenger receptor B (SR-B/CD36), low-density lipoprotein receptor-related protein 1 (LRP1), apolipoprotein E receptor-2 (ApoER2) and very-low-density lipoprotein receptor (VLDL-R) reducing the lipoprotein concentration and slowing thrombosis. In addition to cardiovascular diseases, PCSK9 is also used in pancreatic cancer, sepsis, and Parkinson’s disease. Currently marketed PCSK9 inhibitors include alirocumab, evolocumab, and inclisiran, as well as small molecules, nucleic acid drugs, and vaccines under development. This review systematically summarized the application, preclinical studies, safety, mechanism of action, and latest research progress of PCSK9 inhibitors, aiming to provide ideas for the drug research and development and the clinical application of PCSK9 in cardiovascular diseases and expand its application in other diseases.
cATR Tracing Approach to Identify Individual Intermediary Neurons Based on Their Input and Output: A Proof-of-Concept Study Connecting Cerebellum and Central Hubs Implicated in Developmental Disorders
Authors: van Hoogstraten Willem S. , Lute Marit C. C. , Nusselder Hugo , Kros Lieke , van den Maagdenberg Arn M. J. M. , De Zeeuw Chris I.
Published: September 2022

Over the past decades, it has become increasingly clear that many neurodevelopmental disorders can be characterized by aberrations in the neuro-anatomical connectome of intermediary hubs. Yet, despite the advent in unidirectional transsynaptic tracing technologies, we are still lacking an efficient approach to identify individual neurons based on both their precise input and output relations, hampering our ability to elucidate the precise connectome in both the healthy and diseased condition. Here, we bridge this gap by combining anterograde transsynaptic- and retrograde (cATR) tracing in Ai14 reporter mice, using adeno-associated virus serotype 1 expressing Cre and cholera toxin subunit B as the anterograde and retrograde tracer, respectively. We have applied this innovative approach to selectively identify individual neurons in the brainstem that do not only receive input from one or more of the cerebellar nuclei (CN), but also project to the primary motor cortex (M1), the amygdala or the ventral tegmental area (VTA). Cells directly connecting CN to M1 were found mainly in the thalamus, while a large diversity of midbrain and brainstem areas connected the CN to the amygdala or VTA. Our data highlight that cATR allows for specific, yet brain-wide, identification of individual neurons that mediate information from a cerebellar nucleus to the cerebral cortex, amygdala or VTA via a disynaptic pathway. Given that the identified neurons in healthy subjects can be readily quantified, our data also form a solid foundation to make numerical comparisons with mouse mutants suffering from aberrations in their connectome due to a neurodevelopmental disorder.
Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity
Authors: Tomokiyo Mikado , Tonetti Fernanda Raya , Yamamuro Hikari , Shibata Ryoko , Fukuyama Kohtaro , Gobbato Nadia , Albarracin Leonardo , Rajoka Muhammad Shahid Riaz , Kober A. K. M. Humayun , Ikeda-Ohtsubo Wakako , Villena Julio , Kitazawa Haruki
Published: September 2022

Beneficial microbes with immunomodulatory capacities (immunobiotics) and their non-viable forms (postimmunobiotics) could be effectively utilized in formulations towards the prevention of respiratory viral infections. In this study, novel immunobiotic strains with the ability to increase antiviral immunity in porcine alveolar macrophages were selected from a library of Lactobacillus gasseri. Postimmunobiotics derived from the most remarkable strains were also evaluated in their capacity to modulate the immune response triggered by Toll-like receptor 3 (TLR3) in alveolar macrophages and to differentially regulate TLR3-mediated antiviral respiratory immunity in infant mice. We provide evidence that porcine alveolar macrophages (3D4/31 cells) are a useful in vitro tool for the screening of new antiviral immunobiotics and postimmunobiotics by assessing their ability to modulate the expression IFN-β, IFN-λ1, RNAseL, Mx2, and IL-6, which can be used as prospective biomarkers. We also demonstrate that the postimmunobiotics derived from the Lactobacillus gasseri TMT36, TMT39 and TMT40 (HK36, HK39 or HK40) strains modulate the innate antiviral immune response of alveolar macrophages and reduce lung inflammatory damage triggered by TLR3 activation in vivo. Although our findings should be deepened and expanded, the results of the present work provide a scientific rationale for the use of nasally administered HK36, HK39 or HK40 to beneficially modulate TLR3-triggerd respiratory innate immune response.
Combination Treatment of Retinoic Acid Plus Focal Adhesion Kinase Inhibitor Prevents Tumor Growth and Breast Cancer Cell Metastasis
Authors: Castro-Guijarro Ana Carla , Vanderhoeven Fiorella , Mondaca Joselina Magali , Redondo Analía Lourdes , Zoppino Felipe Carlos Martin , Fernandez-Muñoz Juan Manuel , Sanchez Angel Matias , Flamini Marina Inés
Published: September 2022

All-trans retinoic acid (RA), the primary metabolite of vitamin A, controls the development and homeostasis of organisms and tissues. RA and its natural and synthetic derivatives, both known as retinoids, are promising agents in treating and chemopreventing different neoplasias, including breast cancer (BC). Focal adhesion kinase (FAK) is a crucial regulator of cell migration, and its overexpression is associated with tumor metastatic behavior. Thus, pharmaceutical FAK inhibitors (FAKi) have been developed to counter its action. In this work, we hypothesize that the RA plus FAKi (RA + FAKi) approach could improve the inhibition of tumor progression. By in silico analysis and its subsequent validation by qPCR, we confirmed RARA, SRC, and PTK2 (encoding RARα, Src, and FAK, respectively) overexpression in all breast cells tested. We also showed a different pattern of genes up/down-regulated between RA-resistant and RA-sensitive BC cells. In addition, we demonstrated that both RA-resistant BC cells (MDA-MB-231 and MDA-MB-468) display the same behavior after RA treatment, modulating the expression of genes involved in Src-FAK signaling. Furthermore, we demonstrated that although RA and FAKi administered separately decrease viability, adhesion, and migration in mammary adenocarcinoma LM3 cells, their combination exerts a higher effect. Additionally, we show that both drugs individually, as well as in combination, induce the expression of apoptosis markers such as active-caspase-3 and cleaved-PARP1. We also provided evidence that RA effects are extrapolated to other cancer cells, including T-47D BC and the human cervical carcinoma HeLa cells. In an orthotopic assay of LM3 tumor growth, whereas RA and FAKi administered separately reduced tumor growth, the combined treatment induced a more potent inhibition increasing mice survival. Moreover, in an experimental metastatic assay, RA significantly reduced metastatic lung dissemination of LM3 cells. Overall, these results indicate that RA resistance could reflect deregulation of most RA-target genes, including genes encoding components of the Src-FAK pathway. Our study demonstrates that RA plays an essential role in disrupting BC tumor growth and metastatic dissemination in vitro and in vivo by controlling FAK expression and localization. RA plus FAKi exacerbate these effects, thus suggesting that the sensitivity to RA therapies could be increased with FAKi coadministration in BC tumors.
Echocardiographic Screening for Rheumatic Heart Disease in a Ugandan Orphanage: Feasibility and Outcomes
Authors: Mapelli Massimo , Zagni Paola , Calbi Valeria , Fusini Laura , Twalib Aliku , Ferrara Roberto , Mattavelli Irene , Alberghina Laura , Salvioni Elisabetta , Opira Cyprian , Kansiime Jackson , Tamborini Gloria , Pepi Mauro , Agostoni Piergiuseppe
Published: September 2022

Background: Rheumatic heart disease (RHD) is a major cause of cardiovascular disease in developing nations, leading to more than 230,000 deaths annually. Most patients seek medical care only when long-term structural and hemodynamic complications have already occurred. Echocardiographic screenings ensure the early detection of asymptomatic subjects who could benefit from prophylaxis, monitoring and intervention, when appropriate. The aim of this study is to assess the feasibility of a screening program and the prevalence of RHD in a Ugandan orphanage. Methods: We performed an RHD-focused echocardiogram on all the children (5–14 years old) living in a north Ugandan orphanage. Exams were performed with a portable machine (GE Vivid-I). All the time intervals were recorded (minutes). Results: A total of 163 asymptomatic children were screened over 8 days (medium age 9.1; 46% male; 17% affected by severe motor impairment). The feasibility rate was 99.4%. An average of 20.4 exams were performed per day, with an average of 15.5 images collected per subject. Pathological mitral regurgitation (MR) was found in 5.5% of subjects, while at least two morphological features of RHD were found in 4.3%, leading to 1 “definite RHD” (0.6%) case and 13 “borderline RHD” cases (8.1%). Six congenital heart defects were also noted (3.7%): four atrial septal defects, one coronary artery fistula and one Patent Ductus Arteriosus. Conclusions: We demonstrated the feasibility of an echocardiographic screening for RHD in an orphanage in Uganda. A few factors, such as good clinical and hygienic care, the availability of antibiotics and closeness to a big hospital, may account for the low prevalence of the disease in our population.
Maternal Nutrition, Body Composition and Gestational Weight Gain on Low Birth Weight and Small for Gestational Age—A Cohort Study in an Indian Urban Slum
Authors: Mamidi Raja Sriswan , Banjara Santosh Kumar , Manchala Sridevi , Babu Ch Khadar , Geddam J. J. Babu , Boiroju Naveen Kumar , Varanasi Bhaskar , Neeraja G. , Reddy G. Venkat Raji , Ramalakshmi B. A. , Hemalatha R. , Meur Gargi
Published: September 2022

Maternal nutritional status and care during pregnancy are essential for adequate birth weight. In this prospective cohort study (N = 1061) in an urban slum, we investigated the association of maternal anthropometry, body composition, gestational weight gain and dietary intakes with low birthweight (LBW, <2.5 kg). About one-third of the women were short (<150 cm), 35% were underweight (<45 kg), 23% suffered from chronic energy deficiency (CED, BMI < 18.5 kg/m2) and another 30% were overweight/obese. The mean age and BMI were 23 years and 21.7 kg/m2, respectively, and haemoglobin was 10.73 g/dL. The mean birthweight (N = 605) was 2.81 ± 0.5 kg, and the average gestational age was 38 ± 2 weeks. About 15% of infants had LBW, and 48% were small for gestational age (SGA). Maternal body composition was assessed by skinfold thickness (SFT) in all trimesters. In the first trimester (N = 762), we found that mean fat-free mass (FFM), fat mass (FM) and body fat percentage (% BF) were 38.86 kg, 11.43 kg and 21.55%, respectively. Low birthweight was significantly associated with preterm deliveries (p < 0.001) and less fat free mass (p = 0.02) in the third trimester. Among other factors were age (p = 0.017), maternal anthropometry (height: p = 0.031; weight: p = 0.059) and fewer antenatal check-ups (p = 0.037). Small size (SGA) was consistently associated with maternal bodyweight at all trimesters (term I, p = 0.013, term II, p = 0.003 and term III, p < 0.001), fat mass in the third trimester (p < 0.001) and maternal height (p = 0.003).
Challenges and Elements Needed for Children with Learning Disabilities in Teaching and Learning the Quran
Authors: Zulkifli Hafizhah , Rashid Syar Meeze Mohd , Mohamed Suziyani , Toran Hasnah , Raus Norakyairee Mohd , Suratman Mohd Nasri
Published: September 2022

People with disabilities have the same right to access education and, therefore, the space and opportunity to study the Quran as other groups. However, there are some issues regarding the teaching of the Quran to students with special learning needs, such as from the aspects of the level of readiness of teachers, the mastery of Islamic Education among teachers who teach Special Education, and the use of teaching aids to teach the Quran. Therefore, this study aimed to identify the challenges, the need to develop a model of teaching and learning the Quran, elements to be included in the development of Quranic teaching, and a learning model for children with learning disabilities. A qualitative methodology was adopted using a case study design. The sample consisted of eight informants who volunteered to be involved in this research. The results show that there are seven main challenges in the teaching and learning of children with learning disabilities, i.e., a lack of stimulus materials, a lack of knowledge, limited time, uncontrolled behavior, traditional teaching, disabilities, and a lack of parental commitment. Thereafter, three themes arose in terms of identifying why it is necessary to develop Quran teaching and learning models for children with learning disabilities, such as the lack of an up-to-date model and the right to education. In addition, there were four themes concerning the elements that need to be included in the development of teaching and learning models for the Quran for children with learning disabilities, i.e., digital teaching aids, visual, audio, and kinesthetic learning styles, activities graded by the level of ability, and sensory support. It is hoped that this study will provide guidance to teachers to further strengthen the teaching profession pertaining to educating children with learning disabilities.
Preparation of Resin-Coated Waterborne Coating Microcapsules and Its Effect on the Properties of Waterborne Coating for Wood Surfaces
Authors: Wang Ying , Yan Xiaoxing
Published: September 2022

In this paper, the related experiments were carried out on microcapsules, with the aim of making the prepolymer react with the core emulsion by in situ polymerization using urea–formaldehyde resin as the wall material and waterborne acrylic wood coating as the core material. The prepared microcapsules were added to the waterborne acrylic wood coating and brushed on wood boards. Then, the gloss, hardness, adhesion, impact resistance and color difference were compared with paint surfaces without microcapsules. When the ratio of the microcapsule core-to-wall material was different from the increase in microcapsule content, the gloss of the coating decreased continuously; the decreasing range was basically the same, and the gloss values of the three core-wall ratio microcapsules were rather similar. With the increase in microcapsule content, the impact resistance of the coating first increased and then decreased. With the increase in microcapsule content, the color difference of the coating also increased continuously. The color difference of the coating with a microcapsule core-wall ratio of 0.67 changed the least, and the coating performance was good. When the core-wall ratio of the microcapsules was 0.67, and the proportion of microcapsules in the paint was 7.0%, the comprehensive properties of this coating were good. This research is of great significance to the future protection and development of wood.
Human Teeth Disease Detection Using Refractive Index Based Surface Plasmon Resonance Biosensor
Authors: Alam Mohammad Khursheed , Dhasarathan Vigneswaran , Natesan Ayyanar , Nambi Ramanujam , Zaman Mahmud Uz , Ganji Kiran Kumar , Basri Rehana , Munisekhar Manay Srinivas , Nagarajappa Anil Kumar , Abutayyem Huda
Published: September 2022

The paper proposes a surface plasmon resonance (SPR) biosensor utilizing MXene and a Molybdenum Disulfide (MoS2) material layer, placed on the Ag metal-based conventional biosensor to detect disease in human teeth. The SPR biosensor works on the principle of attenuated total reflection. The transverse matrix method was utilized for the reflectivity calculation. The thickness of the Ag layer, MXene, and MoS2 were taken as 45, 0.993, and 0.375 nm, respectively. Single-layer MoS2 and two layers of MXene were taken, and the highest sensitivity of the sensor for the enamel, dentin, and cementum was obtained at 83.219 deg/RIU, 91.460 deg/RIU, and 104.744 deg/RIU. MoS2 was used to enhance the biocompatibility of the analyte with the sensing layer. The aqueous solution had been considered as sensing medium.
Fe3O4-Carbon-Based Composite Derived from the Charge-Transfer Reaction Using Waste Tea Leaves as the Carbon Precursor for Enhanced Removing of Azocarmine G2, Methyl Violet 2B, Eosin B, and Toluidine Blue from Aqueous Solution
Authors: Al-Hazmi Ghaferah H. , Saad Hosam A. , Refat Moamen S. , Adam Abdel Majid A.
Published: September 2022

Ferric chloride salt (FeCl3) is a typical vacant orbital acceptor that accepts electrons from urea molecules. This donor-acceptor interaction yields a Fe3O4 oxide, which can be used for preparing novel adsorbent material. Activated carbon (AC) materials, derived from biomass precursors and used for environmental remediation, have gained increasing attention owing to their sustainability, eco-friendly nature, ease of fabrication, and cost-effectiveness. Globally, a large amount of consumed tea leaf materials is discarded as solid waste. The present study aimed to reuse consumed tea leaves to generate biomass-derived-ACs and coupling AC with Fe3O4 oxide to generate Fe3O4-carbon-based composite for environmental remediation. The synthesized Fe3O4-carbon-based composite was examined to remove four common organic pollutant dye models from an aqueous solution. The effects of several parameters on the adsorption capacity of the synthesized composite were analyzed, and equilibrium data were examined. We found that the synthesized composite displayed promising adsorption activity against the investigated dyes.
Autofocusing and Self-Healing Optical Vortices Realized via Circular Cubic Phase Modulation
Authors: Xiong Haozhe , Wei Bingyan , Zhang Yuan , Liu Sheng , Li Peng , Wu Yunlong , Zhao Jianlin
Published: September 2022

Optical vortices have drawn extensive research interests due to their widespread applications in various fields. Therefore, it is of great significance to modulate optical vortices to endow them with more properties. Herein, the autofocusing and self-healing properties are introduced to optical vortices via implementing circular cubic phase modulation. The propagation dynamics of the modulated optical vortex is analyzed, and the experimental results match well with the simulations. Moreover, the autodefocusing optical vortices can also be generated, and the flexible switching between the autofocusing state and autodefocusing state can be easily realized by adjusting the helicity of the incident circular polarization. Besides, the topological charges of the two states are also experimentally verified. Our study provides a novel way to modulate optical vortices, which may enrich their applications in optics and photonics.
Dealing with the Problem of Monotone Likelihood in the Inflation of Estimated Effects in Clinical Studies. Comment on Hasegawa et al. Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study. Diagnostics 2020, 10, 826
Authors: Tzeng I-Shiang
Published: September 2022

I read the press article from the Fujita Health University School of Medicine titled “Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study” [...]
The Efficacy of Trabecular Titanium Cages to Induce Reparative Bone Activity after Lumbar Arthrodesis Studied through the 18f-Naf PET/CT Scan: Observational Clinical In-Vivo Study
Authors: Cofano Fabio , Armocida Daniele , Ruffini Livia , Scarlattei Maura , Baldari Giorgio , Di Perna Giuseppe , Pilloni Giulia , Zenga Francesco , Ballante Elena , Garbossa Diego , Tartara Fulvio
Published: September 2022

Background: Titanium trabecular cages (TTCs) are emerging implants designed to achieve immediate and long-term spinal fixation with early osseointegration. However, a clear radiological and clinical demonstration of their efficacy has not yet been obtained. The purpose of this study was to evaluate the reactive bone activity of adjacent plates after insertion of custom-made titanium trabecular cages for the lumbar interbody with positron emission tomography (PET)/computed tomography (CT) 18F sodium fluoride (18F-NaF). Methods: This was an observational clinical study that included patients who underwent surgery for degenerative disease with lumbar interbody fusion performed with custom-made TTCs. Data related to the metabolic-reparative reaction following the surgery and its relationship with clinical follow-up from PET/CT performed at different weeks were evaluated. PET/CTs provided reliable data, such as areas showing abnormally high increases in uptake using a volumetric region of interest (VOI) comprising the upper (UP) and lower (DOWN) limits of the cage. Results: A total of 15 patients was selected for PET examination. Timing of PET/CTs ranged from one week to a maximum of 100 weeks after surgery. The analysis showed a negative correlation between the variables SUVmaxDOWN/time (r = −0.48, p = 0.04), ratio-DOWN/time (r = −0.53, p = 0.02), and ratio-MEAN/time (r = −0.5, p = 0.03). Shapiro−Wilk normality tests showed significant results for the variables ratio-DOWN (p = 0.002), ratio-UP (0.013), and ratio-MEAN (0.002). Conclusions: 18F-NaF PET/CT has proven to be a reliable tool for investigating the metabolic-reparative reaction following implantation of TTCs, demonstrating radiologically how this type of cage can induce reparative osteoblastic activity at the level of the vertebral endplate surface. This study further confirms how electron-beam melting (EBM)-molded titanium trabecular cages represent a promising material for reducing hardware complication rates and promoting fusion.
Thyroid Cancer and Psoriasis: A Nested Case–Control Study
Authors: Kim So Young , Yoo Dae Myoung , Chung Juyong , Choi Hyo Geun
Published: September 2022

Previous researchers have suggested an elevated risk of thyroid cancer (TC) in patients with psoriasis with mixed results. The current study evaluated the relationship of psoriasis with the risk of TC in an adult population. The data from the Korean National Health Insurance Service—Health Screening Cohort ≥ 40 years old were analyzed. In total, 6822 patients with TC were equalized with 27,288 control participants using overlap weighting adjustment based on the propensity score. The history of psoriasis was compared between the TC and control groups using multivariable logistic regression analysis. Secondary analyses were conducted according to age, sex, income, region of residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, obesity, smoking, alcohol consumption, the Charlson Comorbidity Index scores, hypothyroidism, goiter, thyrotoxicosis, and thyroiditis. The history of psoriasis was not different in patients with TC (overlap-weighted odds ratio (OR) = 1.02, 95% confidence intervals (CI) = 0.85–1.22). The <55-year-old group showed a high rate of TC associated with psoriasis (overlap-weighted OR = 1.69, 95% CI = 1.22–2.36, p = 0.002). The population without hypothyroidism demonstrated an increased rate of TC related to psoriasis (overlap-weighted OR = 1.29, 95% CI = 1.06–1.57, p = 0.012). The patients with hypothyroidism showed a low rate of TC for psoriasis (overlap-weighted OR = 0.59, 95% CI = 0.37–0.96, p = 0.034). None of the other subgroups showed an association between psoriasis and TC. Psoriasis was not related to the risk of TC in the overall adult population. Young adults and populations without hypothyroidism indicated an elevated rate of TC for psoriasis.
Data-Driven Thyroid Nodule Diagnosis Using Belief Rule Base
Authors: Jiang Jiang , Zhao Ruirui , Li Xuan , Chang Leilei
Published: September 2022

Doctors’ diagnosis preferences are different, which makes them adopt different assumptions in medical decision making. Taking the diagnosis of thyroid nodules as an example, this study compares three assumptions, namely deletion, imputation based on the distribution (distribution), and benign by default (benign). For deletion, which is the most used assumption, the clinical reports with missing features would be deleted. For distribution, the missing features would be replaced with a distribution of features with respective probabilities. Besides the two assumptions, certain doctors have also stated that they leave benign features unrecorded because they think that such benign features are irrelevant to the final diagnosis. Under the benign assumption, the missing features would be replaced with benign features. The three assumptions are tested comparatively. Moreover, the belief rule base (BRB) is used to construct the diagnostic model under the three assumptions since it is essentially a white-box approach that can provide good interpretability and direct access to doctors and patients. A total of 3766 clinical reports on thyroid nodule diagnosis were collected from ten radiologists over a seven-year period. Case study results validate that the benign by default assumption has produced the optimal results, although different doctors could present varied tendencies towards different assumptions. Guidance and suggestions for doctors’ practical work have been made based on the study results to improve work efficiency and diagnostic accuracy.
Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
Authors: Tufano Antonio , Antonelli Luca , Di Pierro Giovanni Battista , Flammia Rocco Simone , Minelli Rocco , Anceschi Umberto , Leonardo Costantino , Franco Giorgio , Drudi Francesco Maria , Cantisani Vito
Published: September 2022

Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions.
Evaluating Levels of Community Participation in a University-Community Partnership: The Jackson Heart Study
Authors: Addison Clifton , Campbell Jenkins Brenda W. , Fortenberry Marty , Thigpen-Odom Darcel , McCoy Pamela , Young Lavon , White Monique , Wilson Gregory , Woodberry Clevette , Herron Katherine , LaVigne Donna Antoine
Published: September 2022

Objective: This research was designed to evaluate the perceptions of the Jackson Heart Study (JHS) community relating to their levels of involvement in JHS activities that were developed to address health disparities and promote health education and health promotion. Methods: The participants for this study comprised 128 community members, who included JHS participants, as well as family members and other friends of the JHS who resided in the JHS community of Hinds, Madison, and Rankin Counties in Mississippi and attended the JHS Annual Celebration of Life. We used the Chi-Square test to analyze the participants’ responses to the survey questions developed to address the six areas of focus: (1) ways to increase participation in community outreach activities; (2) reasons for participating in community outreach activities; (3) interest in research participation; (4) factors influencing engagement; (5) Participants’ preferences for communicating; (6) Chronic disease prevalence. Results: Participants residing in rural counties perceived television and radio as a medium to increase participation; More female respondents cited trust working with the JSU JHS Community Outreach Center (CORC) as a reason for remaining engaged in the community outreach activities; younger participants under 66 years of age recommended social media as a way to increase participation; participants residing in the rural areas saw their participation in the community outreach activities as a way to address community health problems. Conclusions: The knowledge gained from the details provided by the JHS community members can be used to refine research studies in existence, while promoting their sustainability.