bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets
Authors: Reina-Couto Marta , Pereira-Terra Patrícia , Quelhas-Santos Janete , Silva-Pereira Carolina , Albino-Teixeira António , Sousa Teresa
Published: October 2021

Inflammation has been recognized as a major pathophysiological contributor to the entire spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with preserved ejection fraction, acute HF and cardiogenic shock. Nevertheless, the results of several trials attempting anti-inflammatory strategies in HF patients have not been consistent or motivating and the clinical implementation of anti-inflammatory treatments for HF still requires larger and longer trials, as well as novel and/or more specific drugs. The present work reviews the different inflammatory mechanisms contributing to each type of HF, the major inflammatory mediators involved, namely tumor necrosis factor alpha, the interleukins 1, 6, 8, 10, 18, and 33, C-reactive protein and the enzymes myeloperoxidase and inducible nitric oxide synthase, and their effects on heart function. Furthermore, several trials targeting these mediators or involving other anti-inflammatory treatments in human HF are also described and analyzed. Future therapeutic advances will likely involve tailored anti-inflammatory treatments according to the patient’s inflammatory profile, as well as the development of resolution pharmacology aimed at stimulating resolution of inflammation pathways in HF.
Lung Perfusion Assessment by Bedside Electrical Impedance Tomography in Critically Ill Patients
Authors: Xu Mengru , He Huaiwu , Long Yun
Published: October 2021

As a portable, radiation-free imaging modality, electrical impedance tomography (EIT) technology has shown promise in the bedside visual assessment of lung perfusion distribution in critically ill patients. The two main methods of EIT for assessing lung perfusion are the pulsatility and conductivity contrast (saline) bolus method. Increasing attention is being paid to the saline bolus EIT method in the evaluation of regional pulmonary perfusion in clinical practice. This study seeks to provide an overview of experimental and clinical studies with the aim of clarifying the progress made in the use of the saline bolus EIT method. Animal studies revealed that the saline bolus EIT method presented good consistency with single-photon emission CT (SPECT) in the evaluation of lung regional perfusion changes in various pathological conditions. Moreover, the saline bolus EIT method has been applied to assess the lung perfusion in a pulmonary embolism and the effect of positive end-expiratory pressure (PEEP) on regional ventilation/perfusion ratio (V/Q) and acute respiratory distress syndrome (ARDS) in several clinical studies. The implementation of saline boluses, data analyses, precision, and cutoff values varied among different studies, and a consensus must be reached regarding the clinical application of the saline bolus EIT method. Further study is required to validate the impact of the described saline bolus EIT method on decision-making, therapeutic management, and outcomes in critically ill patients.
Continuous Lighting Promotes Plant Growth, Light Conversion Efficiency, and Nutritional Quality of Eruca vesicaria (L.) Cav. in Controlled Environment With Minor Effects Due to Light Quality
Authors: Proietti Simona , Moscatello Stefano , Riccio Francesca , Downey Peter , Battistelli Alberto
Published: October 2021

Light-emitting diode lamps can allow for the optimization of lighting conditions in artificial growing environments, with respect to light quality, quantity, and photoperiod extension, to precisely manage resources and crop performance. Eruca vesicaria (L.) Cav. was hydroponically cultured under three light treatments to investigate the effect on yield and nutritional properties of rocket plants. A treatment of (W-12h) having a12/12 h light/dark at 600 μmol m−2 s−1 provided by LEDs W:FR:R:B = 12:2:71:15 was compared with two treatments of continuous lighting (CL), 24 h light at 300 μmol m−2 s−1 provided by cool white LEDs (W-CL), and by LED R:B = 73:27 (RB-CL). CL enhanced the growth of the rocket plants: total fresh biomass, leaf fresh weight, and shoot/root ratio increased in W-CL, and leaf dry weight, leaf dry matter %, root fresh and dry weight, and specific leaf dry weight (SLDW) increased in RB-CL. Total carbon content was higher in RB-CL, whereas total nitrogen and proteins content increased in W-12h. Both W-CL and RB-CL increased carbohydrate content in the rocket leaves, while W-CL alone increased the sugar content in the roots. Fibers, pigments, antioxidant compounds, and malic acid were increased by CL regardless of the light spectrum applied. Nitrate was significantly reduced in the rocket leaves grown both in W-CL and RB-CL. Thus, the application of CL with low light intensity can increase the yield and quality value of rocket, highlighting that careful scheduling of light spectrum, intensity, and photoperiod can improve the performance of the crop.
Lightweight Fruit-Detection Algorithm for Edge Computing Applications
Authors: Zhang Wenli , Liu Yuxin , Chen Kaizhen , Li Huibin , Duan Yulin , Wu Wenbin , Shi Yun , Guo Wei
Published: October 2021

In recent years, deep-learning-based fruit-detection technology has exhibited excellent performance in modern horticulture research. However, deploying deep learning algorithms in real-time field applications is still challenging, owing to the relatively low image processing capability of edge devices. Such limitations are becoming a new bottleneck and hindering the utilization of AI algorithms in modern horticulture. In this paper, we propose a lightweight fruit-detection algorithm, specifically designed for edge devices. The algorithm is based on Light-CSPNet as the backbone network, an improved feature-extraction module, a down-sampling method, and a feature-fusion module, and it ensures real-time detection on edge devices while maintaining the fruit-detection accuracy. The proposed algorithm was tested on three edge devices: NVIDIA Jetson Xavier NX, NVIDIA Jetson TX2, and NVIDIA Jetson NANO. The experimental results show that the average detection precision of the proposed algorithm for orange, tomato, and apple datasets are 0.93, 0.847, and 0.850, respectively. Deploying the algorithm, the detection speed of NVIDIA Jetson Xavier NX reaches 21.3, 24.8, and 22.2 FPS, while that of NVIDIA Jetson TX2 reaches 13.9, 14.1, and 14.5 FPS and that of NVIDIA Jetson NANO reaches 6.3, 5.0, and 8.5 FPS for the three datasets. Additionally, the proposed algorithm provides a component add/remove function to flexibly adjust the model structure, considering the trade-off between the detection accuracy and speed in practical usage.
Conventional and Molecular Breeding Tools for Accelerating Genetic Gain in Faba Bean (Vicia Faba L.)
Authors: Adhikari Kedar N. , Khazaei Hamid , Ghaouti Lamiae , Maalouf Fouad , Vandenberg Albert , Link Wolfgang , O'Sullivan Donal M.
Published: October 2021

Faba bean is a cool-season grain legume crop, which is grown worldwide for food and feed. Despite a decrease in area under faba bean in the past, the interest in growing faba bean is increasing globally due to its high seed protein content and its excellent ecological service. The crop is, however, exposed to diverse biotic and abiotic stresses causing unstable, low grain yield. Although, sources of resistance to main diseases, such as ascochyta blight (Ascochyta fabaeSpeg.), rust (Uromyces viciae-fabae(Pers.) Schroet.), chocolate spot (Botrytis fabaeSard.) and gall disease (Physioderma viciae), have been identified, their resistance is only partial and cannot prevent grain yield losses without agronomical practices. Tightly associated DNA markers for host plant resistance genes are needed to enhance the level of resistance. Less progress has been made for abiotic stresses. Different breeding methods are proposed, but until now line breeding, based on the pedigree method, is the dominant practice in breeding programs. Nonetheless, the low seed multiplication coefficient and the requirement for growing under insect-proof enclosures to avoid outcrossing hampers breeding, along with the lack of tools such as double haploid system and cytoplasmic male sterility. This reduces breeding population size and speed of breeding hence the chances of capturing rare combinations of favorable alleles. Availability and use of the DNA markers such as vicine-convicine (vc−) and herbicide tolerance in breeding programs have encouraged breeders and given confidence in marker assisted selection. Closely linked QTL for several biotic and abiotic stress tolerance are available and their verification and conversion in breeder friendly platform will enhance the selection process. Recently, genomic selection and speed breeding techniques together with genomics have come within reach to accelerate the genetic gains in faba bean. Advancements in genomic resources with other breeding tools, methods and platforms will enable to accelerate the breeding process for enhancing genetic gain in this species.
Intermediary Management and Employee Corporate Culture Identification Mediation and Mediation Effect Verification
Authors: Liu Mingji , Li Jinyao , Xiong Tianlang , Liu Tong , Chen Min
Published: October 2021

This exploration is mainly performed to study the role of corporate culture accepted by employees in enterprise development and its impact on employees themselves. First, the influence of employee participation, cross-cultural management, and corporate culture on the enterprise is realized through the relevant literature. Then, investigation and analysis are carried out with American I Industrial Group as the research object to determine the impact of cross-cultural management on mergers and acquisitions and organizational performance. The results show that the total impact of trust on reuse is 0.264 before mergers and acquisitions; the difference is not statistically significant, and so is the overall impact of mergers and acquisitions. This means that there is no correlation between trust and reuse. However, when the merger is done, the total effect of trust on reuse rises to 1.594, indicating that the difference and the total effect are statistically significant. The data calculation and analysis for the direct impact of trust on reuse and the indirect impact of trust on reuse are 0.667 and 0.926, respectively, which means that the difference is statistically significant. This proves the role of satisfaction in the impact of trust on reuse once mergers and acquisitions are completed. Therefore, in the process of mergers and acquisitions in the future, enterprises must consider the different cultures of employees and company locations and employee participation, which will further affect the organizational performance of enterprises.
Similarity Effect and Purchase Behavior of Organic Food Under the Mediating Role of Perceived Values in the Context of COVID-19
Authors: Liu Chunnian , Zheng Yan , Cao Dayu
Published: October 2021

Due to the influence of COVID-19, people pay more attention to the balance between human and nature and pursue more healthy, environmental and nutritional sustainable products (such as organic food). However, the mainstream consumption of organic food is far less, especially in developing countries like China. Therefore, it is urgent to take effective measures to promote the development of China's organic food market. This current study investigated the relationships between consumers' similarity (i.e., information anxiety, uncertainty, and sustainable consumption attitude), perceived values (i.e., functional value, health value, and environmental value) and organic purchasing behavior based on the Stimulus-Organism-Response (S-O-R) theoretical model and information similarity effect. And considering gender differences in consumers' similarity, perceived values and organic purchasing behavior. Meanwhile, the mediating effects of perceived values on the relationship between consumers' similarity and purchasing behavior were also discussed, considering the background of COVID-19. Data were collected using structured questionnaire survey in first-tier cities in China. A total of 344 consumers of organic foods participated in the study. Structural equation modeling was employed for data analysis. The results indicated the significant association of information anxiety, uncertainty and sustainable consumption attitude with perceived values. And perceived values and sustainable consumption attitude had a positively significant influence on purchase behavior. In addition, environmental value played mediating effects in the relationships between organic purchasing behavior and information anxiety, uncertainty and sustainable consumption attitude. And the impact of sustainable consumption attitude and environmental value on organic purchasing behavior differed in gender. The research not only provides novel insights for understanding organic consumption, but also provides reference for organic sellers to develop sales strategies and policy makers to formulate policies to guide organic consumption, which are conducive to promoting China's organic food industry.
How Do the Children Play? The Influence of Playground Type on Children’s Play Styles
Authors: Stanton-Chapman Tina L. , Schmidt Eric L.
Published: October 2021

Using a mixed-method design, the aims of the current study were to develop an in-depth understanding of (1) children’s social play behaviors on school and community playgrounds, (2) the duration with which children play within varying social play categories, and (3) assessing children’s perspectives of playground activities, their peer relationships, and recommendations for new playgrounds. Six participants were observed for five 30-min observations on a school playground and for five 30-min observations on a community playground. Participants were also interviewed about their experiences and preferences on school and community playgrounds. The direct observation results support and extend previous work, indicating that children’s play skill competence varies by setting. Children demonstrated higher levels of associative and cooperative play on the school playground, but higher levels of solitary and parallel play on the community playground. This difference in play styles by playground appears to be a function of available play partners and is explained by the interview data, which found that children are not comfortable playing with children they do not know.
Remote Relaxation and Acceptance Training for the Management of Stress in Cancer Patients: A Study Protocol
Authors: Marzorati Chiara , Pizzoli Silvia Francesca Maria , Grasso Roberto , Pravettoni Gabriella
Published: October 2021

Background: Cancer patients are now facing a double distinctive challenge of survival against both the disease and fear of contracting COVID-19. This challenge has resulted in the forced adoption of social distancing measures and reorganization of the delivery of medical and psychological treatments. The perceived loneliness and uncertainty increased distress and symptoms burden. In the current period, eHealth interventions might provide valuable benefits in the field of cancer care.

Objective: The overall goal of the study protocol will be to provide an innovative intervention for cancer patients based on an online platform, to help them manage and prevent psychological problems related to social isolation. Specifically, the efficacy of two web-based interventions aimed at lowering stress in cancer patients will be tested and compared.

Methods: One hundred and fifty participants (75 per group) will be enrolled in a two-group randomized trial. The two interventions will be composed either by exercises on relaxation and meditation practices, presented in both automated online content and interactive group sessions or by fixed psychoeducational online content. Stress, anxiety, and depressive symptoms, distress, resilience, and perceived social isolation will be measured before the start of the interventions (T0), 2 weeks (T1), 4 weeks (T2), and 2 months (T3) after the beginning of the interventions in both groups. A repeated measures ANOVA will be performed to test differences in the questionnaires' scores between groups across the four-time points.

Expected Results: We hypothesized greater improvement in the specific domain of stress symptoms (IES-R) assessed in the group receiving the interactive intervention, compared to the group which will receive only fully automated psychoeducational content. Secondarily, we expect the same trend of improvement across all the psychological variables in the blended intervention group.

Conclusions: Implementing these practices on people who are forced into mandatory social isolation may help them become more aware of their mind-body condition and reduce negative effects. Moreover, relaxation techniques help individuals in achieving a greater state of well-being, increasing the ability to cope with stressful situations (resilience), and strengthening the immune system.
An Embodied Cognition Perspective on the Role of Interoception in the Development of the Minimal Self
Authors: Musculus Lisa , Tünte Markus R. , Raab Markus , Kayhan Ezgi
Published: October 2021

Interoception is an often neglected but crucial aspect of the human minimal self. In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans. To do so, we first provide a comparative overview of the central accounts addressing the link between interoception and the minimal self. Grounding our arguments on the embodiment framework, we propose a bidirectional relationship between motor and interoceptive states, which jointly contribute to the development of the minimal self. We present empirical findings on interoception in development and discuss the role of interoception in the development of the minimal self. Moreover, we make theoretical predictions that can be tested in future experiments. Our goal is to provide a comprehensive view on the mechanisms underlying the minimal self by explaining the role of interoception in the development of the minimal self.
A Pilot Event-Related Potentials Study on Mechanisms Underlying a tDCS-Enhanced Food-Specific Response Inhibition Task for Patients With Binge Eating Disorder
Authors: İnce Başak , Max Sebastian M. , Plewnia Christian , Leehr Elisabeth J. , Zipfel Stephan , Giel Katrin Elisabeth , Schag Kathrin
Published: October 2021

Behavioural studies demonstrate alterations in cognitive functioning, particularly impaired response inhibition and increased attentional bias towards food in binge eating disorder (BED). This pilot study aimed to investigate the neurophysiological processing of a food-specific inhibition training combined with anodal transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex (DLPFC) in 16 patients with BED (mean age = 38.6, mean BMI = 33.7 kg/m2). Patients performed a food-specific antisaccade task at baseline (T0) and in a cross-over design with verum vs. sham stimulation at T1 and T2. We investigated (i) event-related potentials (ERPs; N2, ERN and P3 amplitudes) while executing the task at baseline, (ii) whether baseline ERPs would predict task performance at T1 and T2 and (iii) associations between ERPs, eating disorder pathology and impulsivity at baseline. The mean amplitude of N2 was less pronounced in erroneous saccades (ES) than correct saccades (CS), whereas ERN and P3 mean amplitudes were more pronounced in ES. Moreover, the P3 mean amplitude of ES predicted the percentage of ES at both follow up-measurements irrespective of the applied stimulation (sham vs. verum). N2 in trials with correct saccades were negatively correlated with nonplanning trait impulsivity, while P3 in erroneous antisaccade trials was negatively correlated with food-related impulsivity. Overall, the findings of reduced ERN, enhanced P3 and N2 amplitude might be interpreted as difficulties in response inhibition towards food in individuals with BED. In particular, P3 predicts task outcome at follow-up and might represent a potential marker for inhibitory control processes.
How to Improve Entrepreneurship Education in “Double High-Level Plan” Higher Vocational Colleges in China
Authors: Huang Yangjie , Zhang Yanzi , Long Zehai , Xu Da , Zhu Ruijie
Published: October 2021

Entrepreneurship education complements vocational education in helping students develop their career prospects. This empirical study comprehensively analyzed sample data of 13,885 students from 40 “Double High-level Plan” higher vocational colleges in China using robust standard error regression analysis and other methods. The results showed that Entrepreneurship Practice (EP), Entrepreneurship Curriculum (EC), and Integration of Entrepreneurship Education and Professional Education (IEEPE) have a significant positive effect on Entrepreneurship Education Performance (EEP), with EP being the most important factor. Furthermore, ascribed factors (gender, household registration, only child or not, whether parents have entrepreneurial experience) and self-achieved factors (double high-level type, school area, subject major, whether to accept social entrepreneurship education) were found to affect students' perception of investment in entrepreneurship education. The study summarizes the existing problems of entrepreneurship education in “Double High-level Plan” higher vocational colleges and proposes four suggestions: pursue the integrated development of entrepreneurship education and “Double High-level” construction, advance both theoretical education and practical education, promote digital reform of the “three teaches” (teachers, teaching materials, and teaching methods), and develop entrepreneurship education in a comprehensive and balanced manner. This has certain theoretical and practical significance for the improvement of entrepreneurship education in other developing countries.
Validation of a Kazakhstani Version of the Mental Health Continuum—Short Form
Authors: Hernández-Torrano Daniel , Ibrayeva Laura , Muratkyzy Ainur , Lim Natalya , Nurtayev Yerden , Almukhambetova Ainur , Clementi Alessandra , Sparks Jason
Published: October 2021

Positive mental health and well-being are significant dimensions of health, employment, and educational outcomes. Research on positive mental health and well-being requires measurement instruments in native languages for use in local contexts and target populations. This study examines the psychometric properties of the Kazakhstani version of the Mental Health Continuum—Short Form (MHC-SF), a brief self-report instrument measuring emotional, social, and psychological well-being. The sample included 664 University students (425 females) purposefully selected in three higher education institutions in South, East, and Central Kazakhstan. Their average age was 20.25 and ranged from 18 to 43. Participants completed a Kazakhstani version of the MHC-SF online. Statistical analyses to evaluate the structural validity, reliability, and measurement invariance of the Kazakhstani version of the MHC-SF were performed. The results confirmed the superiority of the bifactor model (i.e., three separated factors of well-being plus a general factor of well-being) over the alternatives. However, most of the reliable variance was attributable to the general well-being factor. Subscale scores were unreliable, explaining very low variance beyond that explained by the general factor. The findings demonstrated the measurement invariance of the MHC-SF across gender and age. Overall, these findings support the use of the Kazakhstani version of the MHC-SF to examine a general factor of well-being and the measurement invariance of the instrument across gender and age groups. However, the results advise against the interpretation of the subscale scores as unequivocal indicators of emotional, social, and psychological well-being.
Recidivism Rates of Treated, Non-Treated and Dropout Adolescent Who Have Sexually Offended: a Non-Randomized Study
Authors: Carpentier Julie , Proulx Jean
Published: October 2021

The primary objective of this study was to evaluate the effectiveness of a cognitive-behavioral treatment in reducing recidivism by adolescents who have sexually offended (ASO). A secondary objective was to determine whether typologies based on victim age (child, adult/peer, mixed) and relationship (intrafamilial, extra familial, intra/extra familial) discriminate ASO in terms of response to treatment and recidivism. The sample comprised 327 adolescents 12–18 years old (M = 15.8 years, SD = 1.9) who were evaluated in an outpatient clinic after committing a contact sexual assault. Official data on recidivism (criminal charges) was collected after a follow-up period of 21–162 months (M = 7.8 years, SD = 32.2). Survival analysis indicated that adolescents who completed treatment (n = 62) had a recidivism rate for violence (including sexual violence) almost half that of adolescents who had either not completed the treatment or not received treatment (n = 261), (16.1 vs. 30.7%). Neither of the two typologies studied had any effect on the completion of treatment. However, sexual aggression against adults/peers was associated with an increased probability of violent re-offending. These results confirm the effectiveness of this cognitive-behavioral treatment —which targets risk factors associated with sexual aggression as well as those associated with violence in general—in ASO.
Investigating the Correlation Among Chinese EFL Teachers' Self-efficacy, Work Engagement, and Reflection
Authors: Han Yawen , Wang Yongliang
Published: October 2021

As the forerunners of education, teachers and their psycho-affective variables have been the focus of numerous studies in the past decades. To add to this line of inquiry, the present study aimed to scrutinize the correlation among English as a foreign language (EFL) teachers' self-efficacy, work engagement, and reflection in the context of China. To do so, three previously validated questionnaires related to each of the variables were distributed among Chinese EFL teachers with various experiences and academic degrees, and a sample of 614 completed the questionnaires. The results of Pearson's Product-moment correlation revealed that the participants' self-efficacy, work engagement, and reflection were positively correlated. Moreover, the results of regression analysis and ANOVA demonstrated that Chinese EFL teachers' self-efficacy and work engagement significantly predicted their reflection. The findings have viable takeaways for EFL teachers and teacher education programs in that they can invest more time and energy in promoting psychological factors in teaching the English language along with pedagogical issues.
Risks in Adolescent Adjustment by Internet Exposure: Evidence From PISA
Authors: Ortega-Ruipérez Beatriz , Castellanos Sánchez Almudena , Marcano Beatriz
Published: October 2021

Problematic use and abuse of the Internet has manifested new risks among adolescents that affect academic, social, and emotional adjustment. In the academic domain, the role of Internet use on school performance and learning is studied, including the level of competence as a factor in this domain. On the social level, we measure how Internet use affects school climate and problems related to bullying. On the emotional aspect, the relationship between Internet use and satisfaction and positive feelings is studied, including wellbeing as a construct part of this domain. To find these relationships, data obtained from the Program for International Student Assessment survey, 2018 edition are used. Structural equation modeling was used to determine the most significant relationships between the aspects studied and Internet use. Internet use includes four independent variables: two on abuse (time of use on a weekday outside of class and on a weekend) and two on problematic use (perception about forgetting time and perceived discomfort if the Internet does not work). The results answer three research questions: (1) how the constructs created relate to the four independent variables on Internet usage, (2) how the observed variables respond to the latent constructs, and (3) how all these constructs are related to each other. These results highlight the need to teach young people to use the Internet in a useful and healthy way, as a preventive measure, and help professionals who detect technology abuse to act with effective measures to prevent the psychological consequences, working on the academic, social, and emotional aspects that have shown the greatest relationship. The problematic Internet use is a complex problem and it is impossible and imprudent to relate it to isolated factors: It is necessary to consider different factors to better understand the problem.
Pathological Skin Picking: Phenomenology and Associations With Emotions, Self-Esteem, Body Image, and Subjective Physical Well-Being
Authors: Gallinat Christina , Stürmlinger Linda Luisa , Schaber Sandra , Bauer Stephanie
Published: October 2021

Pathological skin picking (PSP) refers to the repetitive manipulation of the skin causing wounds, scars, emotional distress, and social impairment. Skin picking disorder was first recognized as a distinct disorder in the DSM-5 and is still understudied in terms of phenomenology, etiology, and associated consequences. However, the body-related pathology suggests that the relation to the own body might be a crucial factor in PSP. Previous studies provided first insights that affected individuals show a more negative body image and lower self-esteem than healthy individuals. The present study sought to investigate skin picking phenomenology, related emotions as well as associations with self-esteem, body image, and subjective physical well-being. The study was conducted as an open online study, and recruitment was generally targeted to individuals of full age and in addition specifically to individuals with PSP. A total of 363 individuals (82.9% female; age: M = 32.6, SD = 13.92) participated and answered various self-report measures. Nearly half of the sample exceeded the cutoff score for pathological skin picking (N = 163; 44.9%). The results suggest that boredom, bodily tension and strong negative feelings often precede PSP episodes. During the episode most individuals seem to experience a loss of control, trance and positive feelings. After the PSP episode, shame, guilt, anger and anger toward themselves are most prominent. As expected, skin picking severity was positively associated with body image disturbances and negatively with self-esteem, and subjective physical well-being. When controlling for depressive symptoms, all associations were reduced, but those with body image disturbances (r = 0.44; p < 0.001), self-esteem (r = −0.27; p < 0.001), subjective physical well-being (r = −0.22; p < 0.001), and peace of mind (r = 0.30; p < 0.01) remained significant. Moreover, greater skin damage due to skin picking was moderately associated with higher body image disturbances. The results indicate that PSP severity is associated with a negative body image and low self-esteem, and suggest that it may be warranted to consider these aspects in the development of future interventions for PSP. However, relations with body image and self-esteem should be examined in longitudinal studies investigating causal relationships between body image, self-esteem and skin picking. Moreover, PSP phenomenology and the role of specific emotions should be investigated in more detail.
Screening the Influence of Biomarkers for Metabolic Syndrome in Occupational Population Based on the Lasso Algorithm
Authors: Xie Qiao-Ying , Wang Ming-Wei , Hu Zu-Ying , Cao Cheng-Jian , Wang Cong , Kang Jing-Yu , Fu Xin-Yan , Zhang Xing-Wei , Chu Yan-Ming , Feng Zhan-Hui , Cheng Yong-Ran
Published: October 2021

Aim: Metabolic syndrome (MS) screening is essential for the early detection of the occupational population. This study aimed to screen out biomarkers related to MS and establish a risk assessment and prediction model for the routine physical examination of an occupational population.

Methods: The least absolute shrinkage and selection operator (Lasso) regression algorithm of machine learning was used to screen biomarkers related to MS. Then, the accuracy of the logistic regression model was further verified based on the Lasso regression algorithm. The areas under the receiving operating characteristic curves were used to evaluate the selection accuracy of biomarkers in identifying MS subjects with risk. The screened biomarkers were used to establish a logistic regression model and calculate the odds ratio (OR) of the corresponding biomarkers. A nomogram risk prediction model was established based on the selected biomarkers, and the consistency index (C-index) and calibration curve were derived.

Results: A total of 2,844 occupational workers were included, and 10 biomarkers related to MS were screened. The number of non-MS cases was 2,189 and that of MS was 655. The area under the curve (AUC) value for non-Lasso and Lasso logistic regression was 0.652 and 0.907, respectively. The established risk assessment model revealed that the main risk biomarkers were absolute basophil count (OR: 3.38, CI:1.05–6.85), platelet packed volume (OR: 2.63, CI:2.31–3.79), leukocyte count (OR: 2.01, CI:1.79–2.19), red blood cell count (OR: 1.99, CI:1.80–2.71), and alanine aminotransferase level (OR: 1.53, CI:1.12–1.98). Furthermore, favorable results with C-indexes (0.840) and calibration curves closer to ideal curves indicated the accurate predictive ability of this nomogram.

Conclusions: The risk assessment model based on the Lasso logistic regression algorithm helped identify MS with high accuracy in physically examining an occupational population.
Parental Attitudes and Hesitancy About COVID-19 vs. Routine Childhood Vaccinations: A National Survey
Authors: Temsah Mohamad-Hani , Alhuzaimi Abdullah N. , Aljamaan Fadi , Bahkali Feras , Al-Eyadhy Ayman , Alrabiaah Abdulkarim , Alhaboob Ali , Bashiri Fahad A. , Alshaer Ahmad , Temsah Omar , Bassrawi Rolan , Alshahrani Fatimah , Chaiah Yazan , Alaraj Ali , Assiri Rasha Assad , Jamal Amr , Batais Mohammed A. , Saddik Basema , Halwani Rabih , Alzamil Fahad , Memish Ziad A. , Barry Mazin , Al-Subaie Sarah , Al-Tawfiq Jaffar A. , Alhasan Khalid
Published: October 2021

Objectives: To quantify parental acceptance of the COVID-19 vaccine and assess the vaccine hesitancy (VH) for COVID-19 vs. childhood vaccines.

Methods: Eight vaccine hesitancy scale (VHS) items, adopted from WHO's Strategic Advisory Group of Immunization (SAGE), were used to assess VH for COVID-19 vaccine vs. routine childhood vaccines. We distributed the online survey to parents with the commence of the national childhood COVID-19 vaccination program in Saudi Arabia.

Results: Among 3,167 parents, 47.6% are decided to vaccinate their children against COVID-19. The most common reasons for refusal were inadequate safety information (69%) and worry about side effects (60.6%). Parents have a significantly greater positive attitudes toward children's routine vaccines vs. the COVID-19 vaccine, with higher mean VHS (±SD) = 2.98 ± 0.58 vs. 2.63 ± 0.73, respectively (p-value < 0.001). Parents agreed more that routine childhood vaccines are more essential and effective as compared to the COVID-19 vaccine (Cohen's D: 0.946, and 0.826, consecutively; T-test p-value < 0.00). There is more parental anxiety about serious side effects of the COVID-19 vaccine vs. routine childhood vaccines (Cohen's D = 0.706, p-value < 0.001). Parents who relied on the Ministry of Health information were more predicted (OR = 1.28, p-value = 0.035) to intend to vaccinate as opposed to those who used the WHO website (OR = 0.47, −53%, p-value < 0.001). In a multivariate logistic regression analysis, the factors associated with intention to vaccinate children were parents who received COVID-19 vaccine, older parents, having children aged 12–18, and parents with lower education levels.

Conclusions: Significant proportion of parents are hesitant about the COVID-19 vaccine because they are less confident in its effectiveness, safety, and whether it is essential for their children. Relying on the national official healthcare authority's website for the source of information was associated with increased acceptance of childhood COVID-19 vaccination. As parental intention to vaccinate children against COVID-19 is suboptimal, healthcare authorities could boost vaccine uptake by campaigns targeting hesitant parents.
Minimal Cycle Representatives in Persistent Homology Using Linear Programming: An Empirical Study With User’s Guide
Authors: Li Lu , Thompson Connor , Henselman-Petrusek Gregory , Giusti Chad , Ziegelmeier Lori
Published: October 2021

Cycle representatives of persistent homology classes can be used to provide descriptions of topological features in data. However, the non-uniqueness of these representatives creates ambiguity and can lead to many different interpretations of the same set of classes. One approach to solving this problem is to optimize the choice of representative against some measure that is meaningful in the context of the data. In this work, we provide a study of the effectiveness and computational cost of several ℓ1 minimization optimization procedures for constructing homological cycle bases for persistent homology with rational coefficients in dimension one, including uniform-weighted and length-weighted edge-loss algorithms as well as uniform-weighted and area-weighted triangle-loss algorithms. We conduct these optimizations via standard linear programming methods, applying general-purpose solvers to optimize over column bases of simplicial boundary matrices. Our key findings are: 1) optimization is effective in reducing the size of cycle representatives, though the extent of the reduction varies according to the dimension and distribution of the underlying data, 2) the computational cost of optimizing a basis of cycle representatives exceeds the cost of computing such a basis, in most data sets we consider, 3) the choice of linear solvers matters a lot to the computation time of optimizing cycles, 4) the computation time of solving an integer program is not significantly longer than the computation time of solving a linear program for most of the cycle representatives, using the Gurobi linear solver, 5) strikingly, whether requiring integer solutions or not, we almost always obtain a solution with the same cost and almost all solutions found have entries in {‐1,0,1} and therefore, are also solutions to a restricted ℓ0 optimization problem, and 6) we obtain qualitatively different results for generators in Erdős-Rényi random clique complexes than in real-world and synthetic point cloud data.
Human Factors Research in Immersive Virtual Reality Firefighter Training: A Systematic Review
Authors: Wheeler Steven G , Engelbrecht Hendrik , Hoermann Simon
Published: October 2021

Immersive virtual reality (VR) shows a lot of potential for the training of professionals in the emergency response domain. Firefighters occupy a unique position among emergency personnel as the threats they encounter are mainly environmental. Immersive VR therefore represents a great opportunity to be utilized for firefighter training. This systematic review summarizes the existing literature of VR firefighting training that has a specific focus on human factors and learning outcomes, as opposed to literature that solely covers the system, or simulation, with little consideration given to its user. An extensive literature search followed by rigorous filtering of publications with narrowly defined criteria was performed to aggregate results from methodologically sound user studies. The included studies provide evidence that suggests the suitability of VR firefighter training, especially in search and rescue and commander training scenarios. Although the overall number of publications is small, the viability of VR as an ecologically valid analog to real-life training is promising. In the future, more work is needed to establish clear evidence and guidelines to optimize the effectiveness of VR training and to increase reliable data through appropriate research endeavors.
Authenticity, Interactivity, and Collaboration in Virtual Reality Games: Best Practices and Lessons Learned
Authors: Wang Annie , Thompson Meredith , Uz-Bilgin Cigdem , Klopfer Eric
Published: October 2021

Virtual reality has become an increasingly important topic in the field of education research, going from a tool of interest to a tool of practice. In this paper, we document and summarize the studies associated with our 4-year design project, Collaborative Learning Environments in Virtual Reality (CLEVR). Our goal is to share the lessons we gleaned from the design and development of the game so that others may learn from our experiences as they are designing, developing, and testing VR for learning. We translate “lessons learned” from our user studies into “best practices” when developing authentic, interactive, and collaborative experiences in VR. We learned that authentic representations can enhance learning in virtual environments but come at a cost of increased time and resources in development. Interactive experiences can motivate learning and enable users to understand spatial relationships in ways that two dimensional representations cannot. Collaboration in VR can be used to alleviate some of the cognitive load inherent in VR environments, and VR can serve as a context for collaborative problem solving with the appropriate distribution of roles and resources. The paper concludes with a summation of best practices intended to inform future VR designers and researchers.
Case Report: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Application in Intraperitoneally Disseminated Inflammatory Myofibroblastic Tumor and in the Youngest Patient in the World: New Indication and Modification of Technique
Authors: Garnier Hanna , Murawski Maciej , Jastrzebski Tomasz , Pawinska-Wasikowska Katarzyna , Balwierz Walentyna , Sinacka Katarzyna , Gorecki Wojciech , Izycka-Swieszewska Ewa , Czauderna Piotr
Published: October 2021

Introduction: Peritoneal metastases occur in cancers that spread to the peritoneal cavity and indicate the advanced stage of the disease. In children they are mainly seen in sarcomas, Gastrointestinal Stromal Tumors and primary disseminated ovarian tumors. Inflammatory Myofibroblastic Tumor (IMT) is a very rare lesion, characterized by an unpredictable clinical course. The absorption of chemotherapeutic agents through the peritoneal-plasma barrier (PPB) is minimized, thus HIPEC procedure limits the systemic exposure to chemotherapy and permits the administration of its higher doses. The main purpose of HIPEC is to remove the visible macroscopic disease in order to achieve complete cytoreduction (CRS).

HIPEC Procedure in Children: Several papers deal with the CRS and HIPEC in children and adolescents, however pediatric experience is still limited. Thus far, the HIPEC procedure has been carried out on patients over 2 years old. The most common indication for the surgery and the best outcome was experienced by patients with desmoplastic small round cell tumor (DSRCT). Most patients received intraperitoneal cisplatin.

HIPEC Modification: A 5-month-old infant was admitted to the Department of Pediatric Oncology due to the abdominal distention and blood in the stool. The Computed Tomography (CT) revealed a solid-cystic mass in the right abdominal area. The primary tumor and numerous peritoneal metastasis were removed and the Inflammatory Myofibroblastic Tumor (IMT) was diagnosed. The patient underwent subsequently CRS and modified HIPEC procedure. To avoid overheating of the infant, the intraperitoneal normothermic chemoperfusion was performed. Due to the low body weight a modified dosage of intraperitoneal doxorubicin was used. The child underwent standard postoperative chemotherapy and received crizotinib therapy. At 12 months follow-up since treatment completion the patient remains in complete remission. To our knowledge this is the youngest patient, the only infant and the first pediatric patient with IMT who underwent the modified HIPEC procedure in the world.

Conclusions: CRS and HIPEC is technically possible also in infants. For its safe course patients selection and technique modification are necessary. Use of HIPEC should be also considered in intraperitoneally disseminated IMT. A complete cytoreductive surgery as the first HIPEC step seems to be the key factor in survival.
Herpesviruses in Captive Chelonians in Europe Between 2016 and 2020
Authors: Leineweber Christoph , Müller Elisabeth , Marschang Rachel E.
Published: October 2021

Herpesviruses are important pathogens in tortoises and turtles, yet little is known about the epidemiology of these viruses. We analyzed herpesviruses detected by PCR in samples from captive chelonians in Europe according to virus strain, host species, year and season in which the animal was tested, and country in which the animal was kept. A total of 4,797 samples submitted to a diagnostic laboratory in Europe between January 2016 and December 2020 were evaluated. Of these, 312 (6.50%) were positive for herpesviruses. The types most commonly found were testudinid herpesvirus (TeHV)1 (143 positive, 45.83%) and TeHV3 (153 positive, 49.04%), but also included TeHV2 (1 positive, 0.32%), TeHV4 (3 positive, 0.96%), Terrapene herpesvirus 1 (7 positive, 2.24%), Trachemys herpesvirus 1 (2 positive, 0.64%), and three previously undescribed herpesviruses (0.96%). Herpesviruses were detected in chelonians in the families Testudinidae, Emydidae, Geoemydidae, and in the suborder Pleurodira. Among the species for which 100 samples or more were available, the highest proportions of positive samples (positivity rates) were found in samples from Horsfield's tortoises (Testudo horsfieldii) (14.96%), and radiated tortoises (Astrochelys radiata) (14.05%). Among tortoises (Testudinidae), viruses were most often detected in the spring, while in emydid turtles (Emydidae) they were most often detected in the summer. A comparison of the positivity rates according to country showed significant differences, with the highest rate in samples from Italy (16.01%). This study indicated possible differences in herpesvirus positivity rates depending on host species, virus strain, year of sampling, season, and country of origin. It provides useful information in further understanding fluctuations in infection rates as well as in helping to guide decision making for herpesvirus diagnostics in chelonian patients. It also provides evidence for the international dispersal of herpesviruses with their hosts through international trade.