bluuebunny/crossref_metadata_2025 huggingface dataset:
The correlation of Nrf2 levels with improvement of NIHSS scores in acute ischemic stroke patients with glutathione antioxidant supplementation
Authors: Sembiring Beirnes Fernando , Retnaningsih Retnaningsih , Rahmatika Alfi , Tugasworo Dodik
Published: January 2025

Background: Acute ischemic stroke triggers complex cellular cascades and increases the production of oxidative stress. Nrf2 (nuclear erythroid-related factor 2) is a transcription factor that regulates a series of neuroprotective antioxidant genes that can improve the clinical outcome of stroke. Glutathione is an antioxidant that can protect cells against oxidative stress and can increase Nrf2 levels. This study aimed to determine the effect of glutathione supplementation on Nrf2 levels and its impact on clinical stroke outcomes. 
Methods: The research design was a randomized controlled trial, single-blind, and pre-posttest group. About 41 acute ischemic stroke subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely the treatment and control groups. Serum Nrf2 levels were examined using the ELISA method from venous blood and clinical outcomes were assessed using the NIHSS score between days 1 and 14. The treatment group received 500 mg capsule glutathione supplements per 12 hours orally for 14 days. Analysis was carried out using Statistical Product and Service Solutions (SPSS) edition 29.
Results: There was a significant difference in the increase in serum Nrf2 levels between the treatment and control groups (p = 0.005). There was an increase in serum Nrf2 levels in the treatment group compared to the control group. There was no significant correlation between increasing Nrf2 levels and improving NIHSS scores (p = 0.331).
Conclusion: There was no correlation between increasing Nrf2 levels and improving NIHSS scores in acute ischemic stroke patients who received glutathione antioxidant supplements.
Angiomyolipoma in child with gross hematuria: A case report
Authors: Alamsyah Mohammad Taufiq , Hutasoit Yonas Immanuel
Published: January 2025

Introduction: Angiomyolipoma (AML) is a rare kidney tumour, and is usually asymptomatic, but acute treatment to reduce fatality is indicated if an acute symptom occurs. In this literature, we report a case of angiomyolipoma in a child with gross hematuria.
Case Description: A 15-year-old patient with bilateral renal angiomyolipoma. The patient complained of bloody urine and blood clots accompanied by intermittent left abdominal pain. A computed Tomography (CT) scan shows that there is an angiomyolipoma-like mass in both kidneys. This indicates that there are acute symptoms that need to be managed. Associated conditions such as tuberous sclerosis (TSC) also needed to be explored due to the fatality. TSC-associated AML is usually bilateral and also with hematuria.
Conclusion: In bilateral AML, we should explore other associated diseases due to the fatality.
Warm stimulation of the vagus auricular nerve (Jacobson nerve) has the effect of reducing pulse frequency, a new method of psychological relaxation?
Authors: Saleh Arman Yurisaldi , Valentina Rizky , Yogi Saputra Dwi Arwandi
Published: January 2025

Introduction:     Research involving warm temperature stimulation of the auricular vagus nerve is still uncommon. This method is considered because using electric current on the auricular vagus nerve can cause discomfort to the subject. Both electric and warm temperature stimulation target type C sensory nerves. Therefore, to stimulate the auricular vagus nerve, we opted for warm temperature stimulation. This study aimed to determine whether warm stimulation of the auricular vagus nerve affects pulse frequency.
Methods: Twenty-six participants who met the inclusion criteria had their pulse frequency measured. After that, they were asked to use an ear warmer that people usually use in four-season countries for 30 minutes, and then each participant's pulse frequency was measured after using the ear warmer.
Result: The results of this study showed that the average pulse rate before using the ear warmer was 100, while the average pulse rate after using ear warmers was 91. There is a decrease in pulse after using ear warmers, with a significant value (p <0.001).
Conclusion:      Research suggests that ear warmers, originally designed for non-therapeutic purposes, may have therapeutic potential. Jacobson's nerve stimulation can reduce heart rate frequency, promoting physical and mental relaxation.
Skin whiplash and ECG changes post jellyfish-encounter: a case report
Authors: Lukito Antonia Anna , Wirawan Marco , Yonas Emir , Pranata Raymond
Published: January 2025

Background: Only a few articles reported severe cardiovascular events such as myocardial infarction or cardiac failure related to jellyfish stings in humans. This case study aims to evaluate the skin whiplash and ECG changes post jellyfish encounter.
Case Presentation: A 61-year-old female presented with pain and tenderness in her right arm, palpitation, and diarrhea. On physical examination, we noted multiple bullae that formed a "whip-like pattern" on the right arm. Admission ECG showed diffuse T wave inversion at precordial leads. On the second day, the ECG showed inverted T waves on all precordial & extremities leads, premature atrial complexes, and prolonged QTc interval (564ms). Laboratory showed elevated Troponin T, fibrinogen, D-dimer, and prothrombin time. The patient was diagnosed with jellyfish envenomation with cardiac injury. Oral zinc gluconate, potassium, and magnesium were given. On the eighth day, the ECG showed inverted T waves were localized to V2-V4, and the QTc interval was back to normal at 409 ms.
Conclusion: Although the severe cardiovascular manifestation of jellyfish envenomation is rare, it should be anticipated. A routine ECG should be performed; if abnormal, it should be followed by troponin evaluation. Echocardiography may be performed if appropriate. Antiarrhythmic medications should only be used in case of malignant ventricular arrhythmia.
Impact of modified yoga compared to conventional therapy on pain characteristics, cardiorespiratory endurance, body flexibility, salivary cortisol levels, and levels of depression, in patients with cervicogenic headache, a randomized clinical trial
Authors: Hasibuan Robiah Khairani , Haris Salim , Octaviana Fitri , Estiasari Riwanti , Sudarsono Nani Cahyani , Widyahening Indah Suci , Kurniasanti Kristiana Siste , Pandelaki Jacub , Rambe Aldy Safruddin
Published: January 2025

Introduction:  Cervicogenic Headache (CGH) is a chronic headache with a significant prevalence. The pain intensity associated with CGH is usually severe, significantly diminishing the quality of life for those affected. Yoga is thought to promote muscle endurance, body flexibility, and muscle elasticity. The author seeks to explore the potential benefits of yoga for individuals suffering from CGH.
Methods: This was a Randomized Control Trial (RCT), conducted at Qadr Hospital, Banten, focusing on patients aged 18-60 years who visited the neurologist with headaches. The inclusion criteria were patients who had chronic headache originating from the neck (CGH) for a minimum of 12 weeks with at least 6 weeks of treatment. The subjects were divided into two groups; the control group, which received medication, and the yoga group, which received medication as well as participated in modified yoga exercises for 12 weeks, 2 times per week with duration of 90 minutes. After 3 months of intervention, the predictors were re-examined.
Result: Out of 53 subjects, 26 were in the control group and 27 were in the yoga group. There were significant differences between the two groups in mean VO2max after the intervention (p = 0.048), mean body flexibility after the intervention (p < 0.001), mean afternoon salivary cortisol after the intervention (p = 0.027), pain characteristics (intensity, frequency, duration (p < 0.001)), and level of depression (p < 0.001).
Conclusion: Modified yoga gives better clinical improvement compared to conventional therapy for CGH patients.
Rate pressure product: The key index for cardiovascular health management
Authors: Sarvasti Dyana
Published: January 2025

In order to prevent and treat cardiovascular illnesses, cardiovascular health management is essential. The rate pressure product (RPP) is a crucial indicator frequently used to evaluate cardiovascular health. This index, calculated by multiplying the heart rate by the systolic blood pressure, provides valuable information regarding the workload of the heart and its oxygen demand. It serves as an important indicator of cardiac function and overall cardiovascular health. Several factors can affect RPP, including physical activity, emotional stress, and the use of certain medications. Despite its significance in assessing cardiovascular health, there is ongoing debate regarding the ideal range of RPP and its interpretation. This conflicting perspective on the interpretation of RPP raises important questions about its utility in evaluating cardiovascular health and the thresholds that should be considered normal or indicative of potential health issues. Further research and consensus among experts in the field are necessary to reconcile these conflicting views and provide clearer guidelines for the clinical use of RPP as a marker of cardiovascular health. In conclusion, RPP, a key cardiovascular health management index, provides valuable insights into cardiac function and overall cardiovascular health. Thus, it is an important index for monitoring and managing cardiovascular health.
Assessing knowledge, awareness, and attitudes between rural and urban communities in Indonesia regarding cleft lip and palate care
Authors: Marizal Defi , Al-Fessi Reza , Pramono Coen , Bhagat James Antony , Rizqiawan Andra , Humidat Ahmad
Published: January 2025

Background: Insufficient understanding and consciousness regarding cleft lip and palate (CLP) deformity could increase unfavorable perceptions and perspectives. This study aims to determine the differences between urban and rural communities regarding knowledge, awareness, and attitudes regarding CLP care.
Methods: This research was a cross-sectional descriptive study with the aid of an administered questionnaire conducted among 69 participants as patient's parent attending Universitas Airlangga Dental Hospital, urban Communities, and community health center Nusa Tenggara, rural communities; it was carried out in the 2022-2023 period in social service activities. Data were analyzed using SPSS version 24.0 for Windows.
Results: The data were analyzed using the Chi-Square statistical test to measure whether there were significant differences among knowledge, awareness, and attitudes variables. There were statistically significant differences between rural and urban communities for knowledge (p=0.012), awareness (p=0.000), and attitudes (p=0.012).
Conclusion: There was a significant differences in the level of knowledge, awareness, and attitude between rural and urban communities in Indonesia.
The effect of Adipose-Derived Mesenchymal Stem Cells (ADMSC) in higher expression of Protein S100, Insulin Growth Factor-1 (IGF-1), Nerve Growth Factor (NGF), nerve fiber diameter, and motor function after end-to-side than end-to-end neurorrhaphy in ischiadicus nerve injury in Sprague-Dawley rats
Authors: Asmara Anak Agung Gde Yuda , Kawiyana I Ketut Siki , Bakta I Made , Suroto Heri , Astawa Putu , Suyasa I Ketut
Published: January 2025

Background: Management of peripheral nerve injury remains a challenge in clinical practice. Several research focus on alternative procedures and regenerative augmentation to overcome the weaknesses of end-to-end neurorrhaphy techniques that have become the gold standard. End-to-side neurorrhaphy for the repair of traumatic peripheral nerve injuries has a lower morbidity of donor nerves than end-to-end neurorrhaphy. Administration of stem cells is expected to improve the outcome of end-to-side neurorrhaphy. To prove that administering mesenchymal stem cells from adipose (ADMSC) in end-to-side neurorrhaphy can provide a higher degree of nerve healing than end-to-side with amnion and end-to-end with amnion techniques.
Methods: There were three treatment groups in this study, namely end-to-end with amnion, end-to-side with amnion, and end-to-side with amnion and stem cells. In this study, the quality of nerve healing was assessed through the expression of S100 protein, NGF, IGF-1, nerve fiber diameter, and improvement in motor function as assessed by walking track analysis measurements.
Results: The number of samples for each group was nine rats. The end-to-side group with amniotic lining and stem cells had a significant increase in S100 protein expression (193.5 h-score, P < 0.05), NGF (186.2 h-score, P < 0.05), IGF-1 (187.9 h-score, P < 0.05), and nerve fiber diameter (2.91 μm, P < 0.05) compared to the end-to-end group. There was significant improvement in motor function between day 7, day 14, and day 28 after repair in the end-to-side group with stem cell administration.
Conclusion: This study proves that the end-to-side neurorrhaphy technique with the administration of mesenchymal stem cells from adipose tissue can provide a higher quality of nerve healing compared to the end-to-end neurorrhaphy techniques, which are described through the expression of S100, NGF, IGF-1, nerve fiber diameter and improvement of motor function.
Analysis of community health centre staff performance in health service delivery: a meta-analysis
Authors: Rahman Fauzie , Arifin Syamsul , Noor Meitria Syahadatina , Adhani Rosihan , Shadiqi Muhammad Abdan , Rusli Rusdi
Published: January 2025

Background: Performance is needed in every organisation carried out by all human resources. Based on data from the Ministry of Health related to the achievement of community health centre (puskesmas) performance in 2018, the Indonesian state is still not optimal. This study aims to determine the factors associated with the performance of health workers in the work area of the puskesmas.
Methods: This type of research is a meta-analysis study where the data collection of this study was obtained and collected from searching scientific research articles from the time span 2018-2023 using search engines, namely the Garuda Portal and Google Scholar using Publish or Perish and producing 9 national journals that match the inclusion and exclusion criteria.
Result: The results of data analysis showed a relationship between motivation and the performance of health centre staff with a value of p <0.00001, namely p<0.05 and a pooled odds ratio value of 5.92 (95% CI 3.51-9.98). The results of data analysis showed a relationship between leadership and the performance of health centre staff with a value of p<0.00001 and a pooled odds ratio value of 2.40 (95% CI 1.76-3.29). The results of data analysis showed a relationship between work discipline and the performance of community health centre staff, namely a value with a value of p=0.00006, namely p<0.05 and a pooled odds ratio value of 6.24 with a 95% CI range (2.20-17.72).
Conclusion: There is a relationship between motivation, leadership and work discipline with the performance of community health centre staff.
Formulation of cognitive non-technical skill in laparoscopic cholecystectomy learning module: a Delphi consensus
Authors: Nugroho Adianto , Lalisang Toar , Warsinggih Warsinggih , Indriatmi Wresti , Kekalih Aria , Ginting Abdoorahman , Soemantri Diantha , Taher Akmal
Published: January 2025

Background. The laparoscopic cholecystectomy training currently being conducted in Indonesia focuses mainly on technical aspects, leaving many doctors lacking in laparoscopic cholecystectomy cognitive non-technical skills. As a result, there is a potential that laparoscopic cholecystectomy will continue to cause an increase in bile duct damage. Non-technical skills proficiency is essential for a surgeon. However, there is little evidence to support this claim, particularly in Indonesia. We conducted a Delphi study to formulate a learning module for a safe laparoscopic cholecystectomy cognitive non-technical skill.
Methods. A two-round Delphi consensus was carried out from January to February 2023. The experts gathered are 25 digestive surgeons with teaching experiences in general surgery training programs across Indonesia with high laparoscopic cholecystectomy experience.
Results. The agreed-upon learning content for the first Delphi round focuses on building situational awareness skills, which include perceiving warning signs, analyzing the information, and projecting the appropriate amount of work to be done in the future. Perception is supported by anatomical knowledge, an assessment of how difficult the operation is to achieve a Critical View of Safety (CVS), an understanding that uses a checklist and pauses to quickly and accurately analyze objective information, and projections that consider alternative follow-up actions, like bail-out attempts. After that, decisions must be made to complete the procedure securely. Further information on the operation's difficulty level assessment and the importance of CVS as a part of situational awareness skills is provided in the second Delphi round.
Conclusion. Our Delphi consensus successfully created a safe laparoscopic cholecystectomy cognitive non-technical skill learning module that emphasizes situational awareness and debiasing skills through case-based discussions and is assessed using a concordance test.
Effect of vitamin D3 supplementation on Immunoglobulin-G, Interleukin-10, and lymphocyte cells in children for prevention of COVID-19 infection
Authors: Subawa Anak Agung Ngurah , Mulyantari Ni Kadek , Dewi Dewa Ayu Putu Rasmika , Dewi Pande Putu Ayu Patria
Published: January 2025

Background: Vitamin D is a modulator of the adaptive immune system. Vitamin D3 suppresses Th1 cell-mediated responses by suppressing the production of pro-inflammatory cytokines Interleukin-2 and interferon-gamma, also carried out through Vitamin D's interaction with the angiotensin-converting- enzyme-2 (ACE2) protein as the receptor for the entry of SARS-CoV-2 (Covid 19). This study aims to determine the effect of vitamin D3 supplementation on humoral immune response and cellular immune response in children and serum vitamin D levels after vitamin D3 supplementation at a dose of 1000 IU/day for 30 days.
Methods: This experimental study with pre- and post-test-only groups was designed to observe the increase in vitamin D, immunoglobulin G (Ig-G), interleukin-10 (IL-10), and lymphocyte cell counts before and after vitamin D3 administration for 30 days. Sampling was carried out at SD 1 Desa Pandak Gede Kediri Tabanan with research time from December 2021-June 2022
Results: This study is an experimental study with a sample of grade V and grade VI elementary school children in Pandak Gede Village, Kediri, Tabanan and found 26 people (53.8%) were boys the mean age was 10.85 years. There is a significant difference in the average Vitamin D level before and after administering Vitamin D3 (p=0.000). There is no statistically significantly different level of immunoglobulin-G, interleukin-10, and lymphocyte count before and after giving Vitamin D3 with p=0.58,p=0.006, and p=0.132.
Conclusion: COVID-19 was a respiratory illness. One of the important components that possess immunomodulatory and anti-inflammatory properties is vitamin D. Vitamin D deficiency is more common in COVID-19 high-risk populations, including the obese, smokers, and elderly. Following a diagnosis of COVID-19 infection, vitamin D3 treatment was linked to a significant reduction in infection severity and can prevention of COVID-19 infection.
The role of inflammatory cytokines in the pathogenesis of obesity: a crucial area of study in the field of inflammation and obesity
Authors: Antara Gede Eka Rusdi , Saturti Tjokorda Istri Anom , Mahadewa Tjokorda Gde Bagus
Published: January 2025

Obesity is a complex condition characterized by an excessive build-up of fat that poses serious health hazards. Type 2 diabetes, insulin resistance, and cardiovascular disease are metabolic diseases that are significantly influenced by chronic low-grade inflammation. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) are examples of inflammatory cytokines that are important in this inflammatory response. Obese people's adipose tissue is the primary source of TNF-α, which phosphorylates serine residues on insulin receptor substrate-1 (IRS-1) to interfere with the insulin signaling pathway. This prevents IRS-1 from activating downstream signaling molecules that are crucial for the uptake of glucose. Furthermore, TNF-α influences lipid metabolism by inducing lipolysis, which generates free fatty acids that worsen inflammation and insulin resistance. Adipose tissue also secretes IL-6, another pro-inflammatory cytokine that influences the liver's ability to produce glucose and raises insulin resistance. To lessen their detrimental effects on insulin sensitivity and general metabolic health, tailored treatment approaches, including TNF-α, IL-6, and IL-1β in the metabolic inflammation of obesity, must be developed. This will require a clearer understanding of their complex functions. This literature review aims to investigate the function of inflammatory cytokines in the pathophysiology of obesity in greater detail, with the ultimate goal of contributing to a more comprehensive understanding of these complex functions.
Mesenchymal stem cells for treatment of liver cirrhosis
Authors: Purwati  , Sandhi Afriyanti , Nurwito Bagus Satrio , Dwiputra Fajar Wira
Published: January 2025

Background: Liver cirrhosis is caused by long-term liver damage, leading to scar tissue buildup. It often results from viral infections or excessive alcohol use. The disease is usually asymptomatic and found during check-ups, but severe cases can cause liver failure and portal hypertension. Treatment options are limited, with liver transplantation being the only way to improve survival, though it carries risks of rejection and high costs.
Case Presentation: Male patient, 50 years old, with the initials IDP, experiences intermittent abdominal pain and nausea. Physical examination shows moderate health, weight 69 kg, blood pressure 120/80 mmHg, pulse rate 81 bpm, respiratory rate 20 breaths per minute, and axillary temperature 37°C. Pain in the epigastric area is rated 3 out of 10. There is a protrusion in the abdomen and pain in the upper middle and upper left areas of the abdomen. Percussion of the abdomen shows positive undulation, positive shifting dullness, and dull sound in Traube's space. Laboratory tests show elevated levels of total bilirubin, direct bilirubin, indirect bilirubin, SGOT, and SGPT. HBsAg test is positive with a value of 6.83 IU/ml.
Conclusion: Preclinical and clinical research investigating the use of stem cell therapy for the treatment of cirrhosis has yielded promising results.
Improvement in body composition after 12-week basic combat training: a longitudinal study among Republic of Indonesia Defense University cadets
Authors: Purnamasari Dwi Monik , Syafiq Ahmad , Dewi Sartika Ratu Ayu , Lubis Leonardo , Setiarini Asih , Sulistyowati Sigit Fathimah , Sudiarti Trini , Saragih Zaini , Laksminingsih Achadi Endang , Besral
Published: January 2025

Introduction: Body composition is essential for health, as excessive fat can lead to cardiometabolic diseases. Many factors influence body composition, including intense training such as Basic Combat Training (BCT). The nutritional status of Republic of Indonesia Defense University (RIDU) cadets as a reserve component in national defense is important to be monitored because it affects physical performance. This study assessed anthropometry and body composition among RIDU cadets after BCT.  Methods: In this longitudinal study involving 111 female and 146 male RIDU cadets aged 16 to 18, body composition was measured before and after 12 weeks of BCT. Differences were analyzed using the Paired T-test.
Result: The result showed that skinfold bicep, tricep, sub-scapula, supra-clavicula, skinfold thickness, and waist circumference in female and male subjects after BCT were significantly lower while weight and body mass index for age were significantly higher than before BCT. In females, skeletal muscle was higher, but BFP was lower than before.
Conclusion: Overall, body composition improved after BCT, with a more beneficial impact among females. This study highlights that the same training regime benefits females more than males regarding body composition improvements. Additional training regimes should be added for males to achieve comparable results.
Combination of the aorta and vena cava occlusion to stop uncontrolled bleeding in liver trauma: experimental study
Authors: Prakosa Yovan Indra Bayu , Handaya Adeodatus Yuda , Sofii Imam , Barmawi Agus , Setyawan Nurcahya , Anwar Sumadi Lukman , Yushinta Milleninda Pasca
Published: January 2025

Background: Liver trauma occurs in 5% of all trauma cases, with a high mortality rate of 10-15%. The Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) method is being developed to control intra-abdominal bleeding because of its ability to control bleeding with fast and not too invasive. However, it has vulnerabilities in controlling retrohepatic bleeding. Resuscitative Endovascular Balloon Occlusion of the Vena Cava (REBOVC) is an alternative for controlling retrohepatic bleeding. This study aims to determine the effectiveness of the REBOA and REBOVC combination model for controlling liver bleeding and the risk of ischemic injury to the liver.
Methods: This experimental study in Wistar rats compared the REBOA + REBOVC combination model with the Intermittent Pringle Maneuver (IPM) technique to control liver bleeding. The three group variables (OAVC5, OAVC15, and IPM) that were compared were mortality, number of liver bleedings, histopathology of liver damage (Suzuki score), and pre-operative and post-operative blood laboratory results (hemoglobin, leukocyte count, platelet count, SGOT/AST, SGPT/ALT, IL-6, ICAM-1).
Results: There was no difference in mortality between the IPM, OAVC5, and OAVC15 groups (p = 0.276). The OAVC15 group was better at controlling bleeding than the IPM group (p<0.05). IPM and the REBOA + REBOVC combination model did not differ in their effect on liver damage (Suzuki Score) (p>0.05). Only SGPT-Post had a significant mean difference (p=0.044) that influenced mortality in the sample group.
Conclusion: The combination of the REBOA + REBOVC model has more potential to control liver bleeding than IPM without any difference in mortality and the degree of liver damage (Suzuki score).
V-Y advancement flap in fingertip injury: a systematic review
Authors: Grace Claudia  , Yulian Kenny , Hamid Agus Roy Rusly Hariantana
Published: January 2025

Background: Fingertip injuries are among the most frequent issues requiring surgical treatment. While they have different reasons, workhorse flaps like VY advances are often utilized to resurface fingertip amputations. These flaps don't require neurovascular dissection, and they are dependable and easy to execute but it is associated with several complications. This systematic review is to review the clinical value and feasibility of V-Y flap in treatment for fingertip reconstruction.
Methods: This systematic review followed PRISMA 2020 guidelines. Literature search was conducted across PubMed, Science Direct, and Sage Pub, focusing on studies from 2014 to 2024 assessing V-Y flap in treatment for fingertip reconstruction. The search strategy followed the PICO framework. Studies were screened by two independent reviewers according to predetermined inclusion criteria. Data extraction and bias evaluation were conducted separately by each reviewer.  
Result: Literature search resulted in 291 papers. After further screening, 8 studies were included in the final analysis with a total of 129 patients with fingertip injuries. Six studies used the V-Y advancement flap for all fingers with fingertip injuries, while two studies specifically focused on thumb fingertip injuries treated with the V-Y advancement flap. The predominant gender of the patients in these studies were male. The mean 2-point discrimination was one of the objective parameters used in all the included studies, and some studies assessed subjective satisfaction scores.
Conclusion: The value of VY advancement flaps for fingertip reconstruction has been demonstrated. VY advancement flaps are strong flaps that require just one stage of surgery and have produced good neurosensory, functional, and cosmetic results with few problems and morbidities. The treatment is technically straightforward, simpler, and quicker.
Starość w perspektywie pastoralnej
Authors: Dziedzic Jan
Published: January 2025

Publikacja pt. „Starość w perspektywie pastoralnej” wpisuje się w obszar badań nad starością i procesem starzenia. Inspiracją do powstania książki było rosnące zainteresowanie problematyką starzenia oraz potrzeba ukazania fenomenu starości z perspektywy teologii pastoralnej. Celem publikacji jest wsparcie realizacji działań duszpasterskich, które umożliwią osobom starszym dalsze wypełnianie ich powołania w Kościele i świecie. Współczesna sytuacja wymaga twórczych i konstruktywnych działań pastoralnych, gdyż Kościół ma obowiązek wspierać seniorów, a ich obecność i zaangażowanie w społecznościach parafialnych może przynieść znaczące korzyści dla życia wspólnoty. Książka została stworzona jako pomoc w projektowaniu takich rozwiązań. Z uwagi na wielowymiarowość problematyki starzenia, publikacja przedstawia to zjawisko w różnych aspektach, co pozwala na bardziej kompleksowe ujęcie tej złożonej tematyki. Starano się ukazać starość zarówno w kontekście indywidualnym, jak i społecznym. Treść książki podzielona jest na pięć rozdziałów, z których każdy przedstawia odmienną perspektywę na kwestię starości, co w całości tworzy pełniejszy obraz tego fenomenu oraz wyzwań, jakie niesie on dla seniorów, ich rodzin, społeczeństwa i Kościoła. Publikacja odpowiada na wzrastające zainteresowanie tematem starości i starzenia, prezentując szerokie, interdyscyplinarne ujęcie tego zjawiska. Monografia może okazać się szczególnie przydatna duszpasterzom oraz osobom wspierającym seniorów, zwłaszcza tych, którzy cierpią lub są wykluczeni. Dzięki wiedzy zawartej w książce możliwe będzie podejmowanie świadomych i celowych działań na rzecz lepszego zaspokajania potrzeb osób starszych. Proces starzenia jest nieunikniony, można jednak spowolnić jego przebieg i ograniczyć jego skutki. Aby obecność seniorów nie była postrzegana wyłącznie jako problem, konieczna jest zmiana podejścia do starości oraz traktowanie jej jako szansy, a nie wyłącznie wyzwania.
Effect of multiple plasma freeze-thaw cycles on non-invasive prenatal testing
Authors: Ulanova P. V. , Antonenko A. N. , Domoratskaya E. A. , Belov R. O. , Zolotopup A. A. , Leonova V. S. , Krinitsina A. A. , Belenikin M. S.
Published: January 2025

Aim. To assess non-invasive prenatal testing (NIPT) as an informative criterion for quality of blood plasma and cell-free deoxyribonucleic acid (DNA) (cfDNA) in the case of using stabilization tubes at the preanalytical phase, in the example of plasma samples subjected to long-term storage at room temperature (+18о С) and multiple freezethaw cycles.

Material and methods. The plasma samples were subjected to 20 freeze-thaw cycles (-80о С/+18о С), 20-day storage at +18о С with an intermediate cfDNA assessment. The quantitative yield was assessed by fluorometry, while the fragmentation and NIPT data — using realtime polymerase chain reaction (PCR) and high-throughput sequencing, respectively.

Results. After multiple freeze-thaw cycles and long-term plasma storage at room temperature (+18о С), a decrease in the integrity and the concentration of cfDNA by the 20th thawing cycle, as well as a tendency to an increase in concentration by 20 days of storage were observed. Despite this, the NIPT results of the studied samples showed a high degree of coincidence with the NIPT data of the reference samples.

Conclusion. The mere fact of successful NIPT cannot be considered as a reliable and sufficient criterion for assessing the quality of initial plasma and correct preanalytics. This emphasizes the particular importance of monitoring the conditions for transporting and storing plasma and whole blood samples.
Databank of genomic sequences of pathogenic microorganisms and its role in the implementation of epidemiological surveillance
Authors: Semenenko T. A. , Akimkin V. G. , Solomay T. V.
Published: January 2025

Despite the fact that databanks of genomic sequences have clear information links with biological samples, they are an independent intellectual resource in demand among many researchers. To deposit information obtained in the course of molecular genetic studies in Russia, the Virus Genome Aggregator of Russia (VGARus) databank was created.

Aim. To evaluate data on the variability of genetic sequences of the Epstein-Barr virus (EBV), obtained as a result of Russian studies, and the possibility of their integration into the VGARus database for

subsequent use in epidemiological surveillance.

Material and methods. A search for publications was carried out in the PubMed, eLibrary, Cyberleninka databases. In total, the study included 32 papers of Russian and external authors that meet the stated aim. Results. The number of studies containing data on the EBV genetic sequences in the Russian Federation is extremely small. The information presented in publications indicates geographical differences in the ratio of two EBV genotypes, the presence of a special LMP1 TatK gene variant in the Tatars of the Volga region, the difference between Russian EBV samples in the gene encoding the gp350 from those from other world regions. At the same time, information on the genomic sequences obtained in the studies was not deposited in the Russian gene bank in any case.

Conclusion. Expanding the potential of the Russian VGARus platform by including information on the genomic sequences of all pathogenic microorganisms circulating in the Russian Federation will require largescale work that takes into account technical features, biological and information security requirements.
Role of biobanking in the development of personalized medicine in Russia and the world
Authors: Pokrovskaya M. S. , Borisova A. L. , Kiseleva A. V. , Ershova A. I. , Meshkov A. N. , Drapkina O. M.
Published: January 2025

To implement a modern personalized approach in practical healthcare, the latest biomedical technologies should be developed and genetic research should be performed. The analysis of a substantial quantity of data is essential for the investigation of the prevalence of genetic risk factors for various diseases, drug resistance genes, the development of genetic panels to determine the individual risk of pathologies, as well as the creation of genetic risk scores. The review demonstrates through the use of illustrative examples that contemporary biobanks have become a vital component in the field of genetics research, both in Russia and globally. These specialized institutions are capable of accumulating, storing, and utilizing a substantial quantity of biological samples and related data, which is essential for advancing genetic research. The data collected in biobanks and associated clinical information form the basis for large-scale genetic studies conducted in different countries. The efficacy of genetic advancements, such as the early diagnosis of diseases, is contingent upon the number of biobanks, the establishment of collaborative networks among them, and the capacity to leverage digital platforms uniting diverse databases. Biobanks and biobanking have emerged as the foundation for the advancement of personalized medicine.
Artificial Intelligence Technology in Live Streaming E-commerce: Analysis of Driving Factors of Consumer Purchase Decisions
Authors: Mei Lei , Tang Na , Zeng Zhu , Shi Wenwen
Published: January 2025

With the rapid rise of live streaming e-commerce, artificial intelligence (AI) technology has become pivotal in shaping consumer behaviors and purchase decisions. This study explores the application of AI in live streaming e-commerce and analyzes its impact on driving factors behind consumer purchase decisions. Employing a comprehensive methodology including literature review, data analysis, and empirical research, this study identifies key AI-driven factors such as personalized recommendation systems, real-time interaction features, intelligent customer service, and social influence, trust. Conduct a questionnaire survey analysis on 1084 consumers who have participated in live streaming platforms using artificial intelligence technology. The findings reveal that AI significantly enhances consumer engagement and purchase intention, offering valuable insights for both academic research and practical applications in e-commerce platforms.
AntPaP: Patrolling and Fair Partitioning of Graphs by A(ge)nts Leaving Pheromone Traces
Authors: Elazar Gidon , Bruckstein Alfred
Published: January 2025

A team of identical and oblivious ant-like agents – a(ge)nts – leaving pheromone traces, are programmed to jointly patrol an area modeled as a graph. They perform this task using simple local interactions, while also achieving the important byproduct of partitioning the graph into roughly equal-sized disjoint sub-graphs. Each a(ge)nt begins to operate at an arbitrary initial location, and throughout its work does not acquire any information on either the shape or size of the graph, or the number or whereabouts of other a(ge)nts. Graph partitioning occurs spontaneously, as each of the a(ge)nts patrols and expands its own pheromone-marked sub-graph, or region. This graph partitioning algorithm is inspired by molecules hitting the borders of air filled elastic balloons: an a(ge)nt that hits a border edge from the interior of its region more frequently than an external a(ge)nt hits the same edge from an adjacent vertex in the neighboring region, may conquer that adjacent vertex, expanding its region at the expense of the neighbor. Since the rule of patrolling a region ensures that each vertex is visited with a frequency inversely proportional to the size of the region, in terms of vertex count, a smaller region will effectively exert higher “pressure” at its borders, and conquer adjacent vertices from a larger region, thereby increasing the smaller region and shrinking the larger. The algorithm, therefore, tends to equalize the sizes of the regions patrolled, resembling a set of perfectly elastic physical balloons, confined to a closed volume and filled with an equal amount of air. The pheromone based local interactions of agents eventually cause the system to evolve into a partition that is close to balanced rather quickly, and if the graph and the number of a(ge)nts remain unchanged, it is guaranteed that the system settles into a stable and balanced partition.
PERBANDINGAN NEBULISASI LIDOKAIN 2% DAN SPRAY LIDOKAIN 10% DALAM MENCEGAH REFLEKS BATUK PADA PASIEN BRONKOSKOPI DENGAN SEDASI DI RSUP HAJI ADAM MALIK MEDAN
Authors: Pohan Alfindy Maulana , Tanjung Qadri Fauzi , Silaen Ester Lantika Ronauli , Yunanda Yuki
Published: January 2025

Keluhan batuk sering muncul pada pasien yang menjalani bronkoskopi akibat adanya trauma mekanik pada dinding saluran napas. Lidokain digunakan pada bronkoskopi untuk menekan refleks batuk. Penelitian ini bertujuan menilai efek lidokain yang diberikan secara nebulisasi dan spray terhadap refleks batuk pada pasien bronkoskopi. Desain penelitian randomized control trial dilaksanakan di RSUP Haji Adam Malik bulan Agustus sampai dengan September 2023 pada pasien bronkoskopi dengan sedasi. Sampel yang diperoleh 36 pasien yang dibagi menjadi 2 kelompok yaitu kelompok yang mendapat spray Lidokain 10% dan kelompok yang mendapatkan nebulisasi lidokain 2%. Variabel yang diteliti adalah derajat batuk. Analisis statistik yang digunakan adalah mann whitney. Berdasarkan penelitian yang dilakukan terdapat perbedaan derajat batuk yang bermakna pada pada menit ke-15, menit ke-30 dan postperlakuan (p<0,05). Pada kelompok nebulisasi Lidokain 2% derajat batuk lebih rendah dibanding dengan pada kelompok spray Lidokain 10%. Simpulan: Pemberian nebulisasi lidokain 2% lebih efektif menekan derajat batuk dibanding dengan spray lidokain 10% pada tindakan bronkoskopi dengan sedasi.
A Grounded Theory Study on the Support of Young Children at Risk for Disabilities by Daycare Center Teachers
Authors:   The Korean Society of Special Education, Kim Hye Sook , Lee Byoung In
Published: January 2025

The purpose of this study is to identify the experiences of teachers supporting infants and toddlers at risk of disabilities in daycare centers and to deeply reveal the environment and context related to this one. To this end, grounded theory was applied to collect and analyze qualitative data on the experiences and support processes of daycare teachers supporting infants and toddlers at risk of disabilities. A total of 17 research participants were interviewed and the collected data were analyzed using open coding, axial coding, and selective coding methods. As a result of the study, a total of 170 concepts, 44 subcategories, and 15 supercategories were derived, and the relationships between categories were presented as a paradigm model including the central phenomenon, causal , contextual , and mediating conditions, and actions/interactions, and results. The results of the process analysis were analyzed into three stages: ‘Conflict stage’, ‘Overcoming stage’, and ‘Growth stage’, and the core category as a result of the selective coding was ‘Growth experience through the process of overcoming conflict in teaching performance’. Based on the results of this study, more practical and effective support strategies were suggested for daycare teachers supporting infants and toddlers at risk of disabilities.
Estimating the Korean CBM Slope for Individual Students: Utilizing Bayesian Prior Distributions
Authors:   The Korean Society of Special Education, Yeo Seungsoo
Published: January 2025

This study explores the effectiveness of Bayesian prior distributions in estimating the slope of individual students’ reading progress using Curriculum-Based Measurement (CBM). While traditional Ordinary Least Squares (OLS) regression is commonly employed in CBM research, it often yields unstable estimates, particularly when data points are limited or influenced by outliers. This paper investigates whether Bayesian estimation can provide more reliable slope predictions compared to OLS by incorporating prior information from relevant studies. Using Korean first-grade students’ reading CBM data, we compare the accuracy of the two methods through Root Mean Square Error (RMSE) analysis. The findings reveal that Bayesian estimation consistently outperforms OLS, especially for students with reading difficulties, indicating that stronger prior distributions yield more stable results. The implications for special education practitioners include improved decision-making regarding intervention strategies and reduced data collection efforts. This study underscores the potential of Bayesian methods to enhance the precision of individual progress monitoring in educational settings.
The Effect of Digital Financial Education Programs in the Workplace on Financial Capability of Employees with Developmental Disabilities
Authors:   The Korean Society of Special Education, Kim Young Ah , Lee Na Gyeong , Rhee Junga , Lee Youngsun
Published: January 2025

The purpose of this study is to develop and implement a digital financial program for young employees with developmental disabilities and examine its effects on financial literacy, digital financial literacy and ability to use digital financial services. The study’s participants were 27 young adults with developmental disabilities aged 18~35 who participated in the club activity as employees of a subsidiary of an A school corporation in Seoul. In this study, a one group pretest-posttest design was applied, and pretest and posttest were conducted using the translation of the 2022 version of the OECD/INFE Questionnaire and scenario-based evaluation. The digital financial program lasted a total of six sessions and consisted of five topics related to real digital financial life(reasonable financial life, changes in the financial environment and financial consumer protection, budget, expenditure, and savings) selected based on the 2020 National Financial Education Framework. In order to determine the effect of the intervention, paired samples ��-test and Wilcoxon signed-rank test were conducted to see if there was a statistical difference in the degree of change in the pre- and post-scores of the three dependent variables. As a result, scores all improved statistically in the posttest compared to the pretest. This study is significant in that it provides digital finance experience activities for employees with developmental disabilities entering adulthood, and based on this, mediates on how to make financial decisions rationally and how to properly utilize financial services in real digital financial life.
Development and Validation of Work-related Social Skills Scale for Adolescents and Adults in their 20s With Developmental Disabilities
Authors:   The Korean Society of Special Education, An Hyesin , Lee Suk-Hyang
Published: January 2025

The purpose of this study is to develop a scale that measures the work-related social skills of adolescents and adults in their 20s with developmental disabilities and to verify its reliability and validity. A literature review was conducted on prior studies about work-related social skills to derive their concepts and components. A total of 256 initial items were extracted from the review and analysis of measurement tools used to measure social skills and related variables in the preceding study, as well as transition assessment and vocational tools. Next, the content validity was conducted to examine the draft of the scale from experts in vocational education and employment support, and a preliminary survey was conducted on 24 experts. Subsequently, a 68-item questionnaire for the main survey was finalized after modification based on feedback from respondents in the preliminary survey and review by experts. The main survey was conducted on 234 experts in vocational education and employment support, including special education teachers in high schools and post-secondary programs. A total of 223 questionnaires were collected to analyze the reliability and validity of the scale. Finally, the final 37 items were derived from the exploratory factor analysis(EFA) that includes work-related attitude factor(11 items), communication factor(10 items), social problem-solving factor(10 items), and interpersonal relationship factor(6 items). Correlation analysis was conducted to verify the concurrent validity, and the correlation coefficient indicated a significant positive correlation. The overall Cronbach’s α and its value for four factors also indicated high reliability. Based on the findings, the utilization strategies of this tool, the significance and limitations of the study, and suggestions for future research were discussed.