bluuebunny/crossref_metadata_2025 huggingface dataset:
Positive End-Expiratory Pressure Modifies Response to Recombinant and Natural Exogenous Surfactant in Ventilated Immature Newborn Rabbits
Authors: Hilgendorff Anne , Reiss Irwin , Ruppert Clemens , Hanfstingl Thilo , Seliger Ann Sophie , Günther Andreas , Ebsen Michael , Gortner Ludwig
Published: June 2006

Background and Objectives: Different types of surfactant preparations were shown not to exert uniform response in preterm infants suffering from respiratory distress syndrome (RDS). Therefore, the effects of a recombinant surfactant protein C (rSP-C) based preparation and a natural surfactant were compared applying different levels of positive end-expiratory pressure (PEEP) in experimental RDS. Methods: Preterm rabbits (n = 7–14 per group; 27 days gestation; term 30 days) were randomized for receiving either 100 mg/kg rSP-C or natural bovine surfactant and were compared with saline treated controls. Animals were ventilated for 30 min with either 0.3 or 0 kPa PEEP at standardized tidal volumes and lung mechanics were measured as well as lung histology and mRNA expression of surfactant associated proteins B and C by real-time PCR. Results: The PEEP level applied (0.3 vs. 0 kPa) largely influenced dynamic compliance after administration of rSP-C surfactant (4.45 vs. 2.58 ml/kg), whereas natural surfactant improved compliance regardless of the PEEP applied (4.86 vs. 4.24 ml/kg) compared to controls (2.41 vs. 1.55 ml/kg). Accordingly, administration of PEEP significantly increased alveolar count in all groups as well as SP-C mRNA expression, whereas SP-B expression and protein content both remained unchanged. Conclusion: Response to rSP-C surfactant depends on the PEEP level applied in our model of neonatal RDS. These findings should be considered for the conception of clinical trials regarding treatment strategies in neonatal RDS.
Consistent Effects of Genes Involved in Reverse Cholesterol Transport on Plasma Lipid and Apolipoprotein Levels in CARDIA Participants
Authors: Klos Kathy L.E. , Sing Charles F. , Boerwinkle Eric , Hamon Sara C. , Rea Thomas J. , Clark Andrew , Fornage Myriam , Hixson James E.
Published: June 2006

Objective—To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels.

Methods and Results—An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each of 45 genomic regions (54 genes) in blacks (1131 females and 812 males) and whites (1102 females and 954 males) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. SNPs and gene-based 3-SNP haplotypes were evaluated for their ability to predict variation in plasma apolipoproteins (apo) A-I and apoB, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TG). We identified 14 SNPs in 6 candidate gene regions that explained statistically significant variation in the same trait in both genders of at least one race and with evidence of consistent genotype mean trend across gender within race. Haplotype analyses identified 9 candidate gene regions that explained statistically significant variation in one or both races.

Conclusion—Four gene regions,ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2, andCETP, explained plasma lipoprotein variation most consistently across strata. Other gene regions that influence plasma lipid and apolipoprotein levels within race includeCYP7A1,LPL, PPARA, SOAT1, andSREBF2.
Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling
Authors: Morissette Michael R. , Cook Stuart A. , Foo ShiYin , McKoy Godfrina , Ashida Noboru , Novikov Mikhail , Scherrer-Crosbie Marielle , Li Ling , Matsui Takashi , Brooks Gavin , Rosenzweig Anthony
Published: June 2006

Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in many species, from rodents to humans, although its mechanisms of action are incompletely understood. Transcript profiling of hearts from a genetic model of cardiac hypertrophy revealed dramatic upregulation of myostatin, not previously recognized to play a role in the heart. Here we show that myostatin abrogates the cardiomyocyte growth response to phenylephrine in vitro through inhibition of p38 and the serine-threonine kinase Akt, a critical determinant of cell size in many species from drosophila to mammals. Evaluation of male myostatin-null mice revealed that their cardiomyocytes and hearts overall were slightly smaller at baseline than littermate controls but exhibited more exuberant growth in response to chronic phenylephrine infusion. The increased cardiac growth in myostatin-null mice corresponded with increased p38 phosphorylation and Akt activation in vivo after phenylephrine treatment. Together, these data demonstrate that myostatin is dynamically regulated in the heart and acts more broadly than previously appreciated to regulate growth of multiple types of striated muscle.
Comparison of Tissue Plasminogen Activator Administration Management Between Telestroke Network Hospitals and Academic Stroke Centers
Authors: Audebert Heinrich J. , Kukla Christian , Vatankhah Bijan , Gotzler Berthold , Schenkel Johannes , Hofer Stephan , Fürst Andrea , Haberl Roman L.
Published: June 2006

Background and Purpose—

Systemic thrombolysis is the only therapy proven to be effective for ischemic stroke. Telemedicine may help to extend its use. However, concerns remain whether management and safety of tissue plasminogen activator (tPA) administration after telemedical consultation are equivalent in less experienced hospitals compared with tPA administration in academic stroke centers.

Methods—

During the second year of the ongoing Telemedical Pilot Project for Integrative Stroke Care, all systemic thrombolyses in stroke patients of the 12 regional clinics and the 2 stroke centers were recorded prospectively. Patients’ demographics, stroke severity (National Institutes of Health Stroke Scale), frequency of administration, time management, protocol violations, and safety were included in the analysis.

Results—

In 2004, 115 of 4727 stroke or transient ischemic attack patients (2.4%) in the community hospitals and 110 of 1889 patients in the stroke centers (5.8%) received systemic thrombolysis. Prehospital latencies were shorter in the regional hospitals despite longer distances. Door to needle times were shorter in the stroke centers. Although blood pressure was controlled more strictly in community hospitals, symptomatic intracerebral hemorrhage rate (7.8%) was higher (
P
=0.14) than in stroke centers (2.7%) but still within the range of the National Institute of Neurological Disorders and Stroke trial. In-hospital mortality rate was low in community hospitals (3.5%) and in stroke centers (4.5%).

Conclusions—

Although with a lower rate of systemic thrombolysis, there was no evidence of lower treatment quality in the remote hospitals. With increasing numbers of tPA administration and growing training effects, the telestroke concept promises better coverage of systemic thrombolysis in nonurban areas.
Hemostatic Activation and Outcome After Recombinant Tissue Plasminogen Activator Therapy for Acute Ischemic Stroke
Authors: Tanne David , Macko Richard F. , Lin Yan , Tilley Barbara C. , Levine Steven R.
Published: June 2006

Background and Purpose—

Early thrombolytic therapy with intravenous recombinant tissue plasminogen activator (rtPA) improves clinical outcome in acute ischemic stroke (AIS), but impaired endogenous fibrinolysis, thrombin generation, and vascular injury may hamper the efficacy of thrombolysis. We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study.

Methods—

Tissue plasminogen activator (tPA) antigen, thrombin-antithrombin complex (TAT), soluble thrombomodulin, and fibrinogen levels were measured in patients with AIS included in the NINDS rtPA Stroke Study from plasma samples collected at baseline, at 2 hours after treatment, and after 24 hours.

Results—

TAT and tPA antigen levels peaked at 2 hours selectively in the rtPA treatment group, whereas fibrinogen levels dropped at 2 hours and remained low after 24 hours (
P
<0.0001 for interaction effects between time and treatment). At 24 hours, higher levels of tPA antigen were associated with a lower chance of favorable outcome (odds ratio [OR]=0.34; 95% CI, 0.14 to 0.82) selectively in the rtPA group, and higher levels of TAT (OR=1.72; 95% CI, 1.26 to 2.34) in the entire cohort and of thrombomodulin selectively in the rtPA group (OR=4.45; 95% CI, 1.26 to 15.67) were associated with higher 3-month mortality.

Conclusions—

Hemostatic activation after AIS appears to be independently associated with clinical outcome in patients treated with rtPA. However, because we have tested for multiple associations, some may have been identified by chance alone and require further confirmatory studies. On the basis of this exploratory analysis, there is a rationale to investigate the safety and efficacy of protocols in which rtPA is complemented by agents that are antithrombotic and enhance fibrinolysis.
Is the ABCD Score Useful for Risk Stratification of Patients With Acute Transient Ischemic Attack?
Authors: Cucchiara Brett L. , Messe Steve R. , Taylor Robert A. , Pacelli James , Maus Douglas , Shah Qaisar , Kasner Scott E.
Published: June 2006

Background and Purpose—

A 6-point scoring system (ABCD) was described recently for stratifying risk after transient ischemic attack (TIA). This score incorporates age (A), blood pressure (B), clinical features (C), and duration (D) of TIA. A score <4 reportedly indicates minimal short-term stroke risk. We evaluated this scoring system in an independent population.

Methods—

This was a prospective study of TIA patients (diagnosed by a neurologist using the classic <24-hour definition) hospitalized <48 hours from symptom onset. The primary outcome assessment consisted of dichotomization of patients into 2 groups. The high-risk group included patients with stroke or death within 90 days, ≥50% stenosis in a relevant artery, or a cardioembolic source warranting anticoagulation. All others were classified as low risk. Findings on diffusion-weighted MRI (DWI) were also evaluated when performed and patients classified as DWI+ or DWI−.

Results—

Over 3 years, 117 patients were enrolled. Median time from symptom onset to enrollment was 25.2 hours (interquartile range 19.8 to 30.2). Overall, 26 patients (22%) were classified as high risk, including 2 strokes, 2 deaths, 15 with ≥50% stenosis, and 10 with cardioembolic source. The frequency of high-risk patients increased with ABCD score (0 to 1 13%; 2 8%; 3 17%; 4 27%; 5 26%; 6 30%;
P
for trend=0.11). ABCD scores in the 2 patients with stroke were 3 and 6. Of those who underwent MRI, 15 of 61 (25%) were DWI+, but this correlated poorly with ABCD score (0 to 1 17%; 2 10%; 3 36%; 4 24%; 5 13%; 6 60%;
P
for trend=0.24).

Conclusions—

Although the ABCD score has some predictive value, patients with a score <4 still have a substantial probability of having a high-risk cause of cerebral ischemia or radiographic evidence of acute infarction despite transient symptoms.
Identification of Penumbra and Infarct in Acute Ischemic Stroke Using Computed Tomography Perfusion–Derived Blood Flow and Blood Volume Measurements
Authors: Murphy B.D. , Fox A.J. , Lee D.H. , Sahlas D.J. , Black S.E. , Hogan M.J. , Coutts S.B. , Demchuk A.M. , Goyal M. , Aviv R.I. , Symons S. , Gulka I.B. , Beletsky V. , Pelz D. , Hachinski V. , Chan R. , Lee T.-Y.
Published: June 2006

Background and Purpose—

We investigated whether computed tomography (CT) perfusion–derived cerebral blood flow (CBF) and cerebral blood volume (CBV) could be used to differentiate between penumbra and infarcted gray matter in a limited, exploratory sample of acute stroke patients.

Methods—

Thirty patients underwent a noncontrast CT (NCCT), CT angiography (CTA), and CT perfusion (CTP) scan within 7 hours of stroke onset, NCCT and CTA at 24 hours, and NCCT at 5 to 7 days. Twenty-five patients met the criteria for inclusion and were subsequently divided into 2 groups: those with recanalization at 24 hours (n=16) and those without (n=9). Penumbra was operationally defined as tissue with an admission CBF <25 mL · 100 g
−1
· min
−1
that was not infarcted on the 5- to 7-day NCCT. Logistic regression was applied to differentiate between infarct and penumbra data points.

Results—

For recanalized patients, CBF was significantly lower (
P
<0.05) for infarct (13.3±3.75 mL · 100 g
−1
· min
−1
) than penumbra (25.0±3.82 mL · 100 g
−1
· min
−1
). CBV in the penumbra (2.15±0.43 mL · 100 g
−1
) was significantly higher than contralateral (1.78±0.30 mL · 100 g
−1
) and infarcted tissue (1.12±0.37 mL · 100 g
−1
). Logistic regression using an interaction term (CBF×CBV) resulted in sensitivity, specificity, and accuracy of 97.0%, 97.2%, and 97.1%, respectively. The interaction term resulted in a significantly better (
P
<0.05) fit than CBF or CBV alone, suggesting that the CBV threshold for infarction varies with CBF. For patients without recanalization, CBF and CBV for infarcted regions were 15.1±5.67 mL · 100 g
−1
· min
−1
and 1.17±0.41 mL · 100 g
−1
, respectively.

Conclusions—

We have shown in a limited sample of patients that CBF and CBV obtained from CTP can be sensitive and specific for infarction and should be investigated further in a prospective trial to assess their utility for differentiating between infarct and penumbra.
Cathepsin and Calpain Inhibitor E64d Attenuates Matrix Metalloproteinase-9 Activity After Focal Cerebral Ischemia in Rats
Authors: Tsubokawa Tamiji , Solaroglu Ihsan , Yatsushige Hiroshi , Cahill Julian , Yata Kenichiro , Zhang John H.
Published: June 2006

Background and Purpose—

Matrix metalloproteinases (MMPs) and cysteine proteases (calpain and cathepsin B) play an important role in cell death and are upregulated after focal cerebral ischemia. Because there is a significant interaction between MMP-9 with calpain and cathepsin B, we investigated the role of E64d (a calpain and cathepsin B inhibitor) on MMP-9 activation in the rat focal ischemia model.

Methods—

Male Sprague-Dawley rats were subjected to 2 hours of middle cerebral artery occlusion by using the suture insertion method followed by 22 hours of reperfusion. In the treatment group, a single dose of E64d (5 mg/kg IP) was administrated 30 minutes before the induction of focal ischemia, whereas the nontreatment group received dimethyl sulfoxide only. The neurological deficits, infarct volumes, Evans blue extravasation, brain edema, and MMP-9 activation in the brain were determined.

Results—

Pretreatment with E64d produced a significant reduction in the cerebral infarction volume (353.1±19.8 versus 210.3±23.7 mm
3
) and the neurological deficits. Immunofluorescence studies showed MMP-9, calpain, and cathepsin B activation colocalized to both neurons and the neurovascular endothelial cells after ischemia, which was reduced by E64d.

Conclusion—

These results suggest that E64d treatment provides a neuroprotective effect to rats after transient focal cerebral ischemia by inhibiting the upregulation of MMP-9.
White Matter Alterations in Cerebral Amyloid Angiopathy Measured by Diffusion Tensor Imaging
Authors: Salat David H. , Smith Eric E. , Tuch David S. , Benner Thomas , Pappu Vasanth , Schwab Kristin M. , Gurol M. Edip , Rosas H. Diana , Rosand Jonathan , Greenberg Steven M.
Published: June 2006

Background and Purpose—

Cerebral amyloid angiopathy (CAA) represents β-amyloid deposition in the small- and medium-sized vessels of the brain and meninges. CAA contributes to altered vessel function and is associated with white matter damage, cognitive impairment, and most salient, hemorrhagic stroke. We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA.

Methods—

Diffusion tensor imaging was obtained from 11 participants diagnosed with CAA-related intracerebral hemorrhage and 13 matched healthy control participants. Fractional anisotropy (FA) and diffusivity maps were compared using voxel based
t
test and region-of-interest analyses.

Results—

FA was reduced in CAA in temporal white matter and in the splenium of the corpus callosum (
P
<0.001 with ≈17% reduction in temporal white matter and 15% reduction in the splenium). FA was marginally increased in CAA in the posterior limb of the internal capsule and subthalamic gray matter regions (≈7% increase in subthalamic gray). FA changes were bilateral, remained significant in cluster analysis controlling for multiple comparisons, and did not depend on the hemisphere of the cerebral hemorrhage. Diffusivity was not substantially altered.

Conclusions—

These findings suggest that a pattern of regional brain tissue degeneration is a characteristic feature of advanced CAA.
Intravenous Versus Combined (Intravenous and Intra-Arterial) Thrombolysis in Acute Ischemic Stroke
Authors: Sekoranja Lucka , Loulidi Jaouad , Yilmaz Hasan , Lovblad Karl , Temperli Philippe , Comelli Mario , Sztajzel Roman F.
Published: June 2006

Background and Purpose—

Determine feasibility and safety of intravenous (IV) versus combined (IV-IA [intra-arterial]) thrombolysis guided by transcranial color-coded duplex sonography (TCCD).

Methods—

Thirty-three patients eligible for IV thrombolysis, within 3 hours of onset of symptoms, with occlusion in middle cerebral artery territory (TCCD monitoring, thrombolysis in brain ischemia [TIBI] flow grade [0–3]), underwent IV thrombolysis (tissue plasminogen activator, 0.9 mg/kg). In case of recanalization (modification of TIBI score ≥1) after 30 minutes IV thrombolysis was continued over 1 hour; otherwise, it was discontinued, with subsequent IA thrombolysis. Recanalization was determined by TIBI (TCCD) and angiographically by thrombolysis in myocardial infarction (TIMI) flow grades. Clinical outcome measures were assessed at baseline, 24 hours (NIHSS) and 3 months (modified Rankin Scale).

Results—

In the IV group, 10/17 patients (59%) with complete or partial recanalization after 30 minutes had a favorable outcome at 3 months (modified Rankin Scale 0 to 2). TIBI flow grades 3 to 5 after 30 minutes of IV thrombolysis predicted a good prognosis compared with TIBI grades 1 to 2 (
P
<0.05). In the combined IV/IA therapy group (no recanalization after 30 minutes), 9/16 patients (56%) had a favorable outcome at 3 months. One symptomatic intracerebral hemorrhage occurred in each group.

Conclusions—

Combined IV-IA versus IV thrombolysis guided by TCCD was feasible and safe. Recanalization after 30 minutes of IV thrombolysis led to a favorable outcome in 59% of the patients, provided TIBI flow grades were of 3 to 5. In the absence of early recanalization during IV thrombolysis, there was clinical benefit to proceed to IA therapy for a significative proportion of patients (56%).
Museum
Authors: Hetherington Kevin
Published: June 2006

Through analysis of a critical engagement between Blanchot and Malraux on the museé imaginaire, it becomes apparent that both were seeking to understand the relationship between the museum and experience within modernity. This short article seeks to develop these ideas and to understand the museum as a key institutional space of modernity implicated in addressing the changing character of experience in the present. Following Benjamin's distinction between experience as Erfahrung and Erlebnis, the essay argues that the museum has always sought to offer a fabricated sense of Erfahrung through its narrative and display techniques and that this facilitates a distracted mode of reception that is now prominent within contemporary cultural life. Through this we can see that the idea of the museé imaginaire is still a prescient one, but it has moved from the virtual space of the photographic art book to the simulated culture of the museumified city in general.
Persian Poesis
Authors: Fischer Michael M.J.
Published: June 2006

The archive is the place for the storage of documents and records. With the emergence of the modern state, it became the storehouse for the material from which national memories were constructed. Archives also housed the proliferation of files and case histories as populations were subjected to disciplinary power and surveillance. Behind all scholarly research stands the archive. The ultimate plausibility of a piece of research depends on the grounds, the sources, from which the account is extracted and compiled. An expanding and unstable globalizing archive presents particular problems for classifying and legitimating knowledge. Increasingly the boundaries between the archive and everyday life become blurred through digital recording and storage technologies. Not only does the volume of recordable archive material increase dramatically (e.g. the Internet), but the volume of material seen worthy of archiving increases too, as the criteria of what can, or should be, archived expands. Life increasingly becomes lived in the shadow of the archive.
Media Theory
Authors: Hansen Mark B.N.
Published: June 2006

Poised on the cusp between phenomenology and materiality, media institute a theoretical oscillation that promises to displace the empirical-transcendental divide that has structured western meditation on thinking, including the thinking of technics. Because media give the infrastructure conditioning thought without ceasing to be empirical (i.e. without functioning as a transcendental condition), they form the basis for a complex hermeneutics that cannot avoid the task of accounting for its unthematizable infrastructural condition. Tracing the oscillation constitutive of such a hermeneutics as it serves variously to constitute media theory in the work of critics from McLuhan to Kittler, from Leroi-Gourhan to Stiegler, my interrogation ultimately conceptualizes the medium as an environment for life:by giving concrete form to ‘epiphylogenesis’ (the exteriorization of human evolution), concrete media find their most ‘originary’ function not as artifacts but via their participation in human technogenesis (our co-evolution with technics).
Experience
Authors: Lash Scott
Published: June 2006

For Kant, experience is epistemological, whereas ontological experience (Gadamer) is in the first instance poetic and Romantic (Schiller, Goethe). In contradistinction to Kantian Erfahrung, it is most often called Erlebniß. We note further that Erfahrung is cognitive experience while Erlebnis is also aesthetic experience. Dilthey and Husserl understand experience pertaining to knowledge through Erlebnis. In epistemological or classificatory knowledge the parts add up to the whole. Ontological knowledge instead is holistic in which the whole is present in each of the parts. In ontological knowledge we can know things themselves. Ontological experience is particularly important for global knowledge. This is because knowing another culture is not reducible to a culture's qualities or predicates. Culture as a way or form of life is a thingitself. A third type of experience is informational experience. This collapses the epistemological into the ontological and is also increasingly present today. This sort of experience of non-linear information theory can account for the experience of societies, of individual humans, of digital media, of neuronal networks, of phenotypes, urban forms, of cellular organisms, or of inorganic matter.
Cosmopolitanism
Authors: Cheah Pheng
Published: June 2006

In modernity, the concept of cosmopolitanism has changed from an intellectual ethos to a vision of an institutionally embedded global political consciousness. The central problem that troubles cosmopolitanism from its moment of inception in 18th-century philosophy to the globalized present is whether we live in a world that is interconnected enough to generate institutions that have a global regulatory reach and a global form of solidarity that can influence their functioning. Examination of Kant's pre-nationalist cosmopolitanism, Marx's postnationalist cosmopolitanism, and decolonizing socialist nationalism indicates the normative attraction of the nation as a mode of solidarity. Contemporary arguments about new cosmopolitanisms focusing on the rise of transnational networks of global cities, postnational social formations created by migrant and diasporic flows and Habermas's recent revival of Kant's project of cosmopolitan democracy have likewise failed to address the persistence of nationalism as a normative force within the field of uneven globalization.
Classification
Authors: Boyne Roy
Published: June 2006

First thoughts about classification inevitably turn to the simultaneously mundane and extraordinary ambition to capture the universe of all that there is and has been. This dream of the universal has two basic modes (and so the process begins!). First, I will follow the spirit of theos and logos as represented by the Platonic embrace of totality enshrined in Socrates’ scrupulous rejection of rhetorical dishonesty. Second, I will address the later part of the march to subjectivity as expressed by the mechanics of atomism and Cartesian reduction. Following this move from theology to ontology, from in other words the post-synthetic to the post-analytic, I will connect with the sociological destruction of such pretensions to absolute classificatory veracity – a necessary pre-requisite for the engagement of reflexivity and classification to be found in the work of Georges Perec.
Language
Authors: Bishop Ryan , W.P. Phillips John
Published: June 2006

In this article we outline the ways in which questions of language have both revealed problems with conceptions of knowledge and suggested constructive ways of addressing those problems. Having examined the limitations of instrumental notions of language, we outline some alternatives, especially those developed from the middle of the 19th and throughout the 20th century. We locate forceful and influential philosophical interventions in the writings of Nietzsche and Heidegger and foundational revisions in the linguistics of Ferdinand de Saussure and his structuralist inheritors. We also chart the parallel path of literary theory from Mallarmé through Blanchot and poststructuralism to deconstruction. We conclude, after making some observations about the politicization of language in the works of feminist and postcolonial theorists, with some remarks about how the question of language helps to problematize global knowledge.
Poetic Knowledge
Authors: Patke Rajeev S.
Published: June 2006

Whether poetry gives knowledge or not is a question that has been debated from a variety of perspectives, depending on how a society or a culture defines knowledge, and on the function it ascribes to poetry in relation to that definition. The civilizations of Asia and the Middle East have generally taken the line that poetry deals primarily with affects, emotions and feelings. The West has had a more complicated history of responses. One way of making sense of this history is to map rival claims as split over the idea of scientific knowledge, where it affects notions of the poetic function. The mapping, through all its manifold branches, gives clear indications that claims to knowledge – both those made on behalf of poetry, and those denied to poetry – depend more on assumptions, predispositions and cultural conditioning than on rational argument or critical debate. The resulting variety also suggests that the cultural relativism that affects such debates is unlikely to arrive at resolutions except of the contingent kind.
Technology
Authors: McQuire Scott
Published: June 2006

This essay traces the increased centrality of technology to social life across the period of modernity. It examines major shifts in thinking about technology which underpin the shift from industrial to post-industrial society, and the emergence of concepts such as ‘technoscience’ and ‘technoculture’. It argues that a critical analysis of technology must probe the way that histories of technological progress have been implicated in colonial hierarchies privileging the West. In examining the extension of technology from machines that make things to ‘machines that think’, including biotechnology and computerized ‘aritificial life’, something implied in every historical iteration of technology is laid bare: defining the technological activates the border between nature and culture, and goes to the heart of what it means to be human.
Network
Authors: van Loon Joost
Published: June 2006

Network is a device for organizing and conceptualizing non-linear complexity. Networks defy narrative, chronology and thus also genealogy because they entail a multiplicity of traces. Networks problematize boundaries and centrality but intensify our ability to think in terms of flows and simultaneity. As a concept, network has been highly conducive to theorizing phenomena and processes such as globalization, digital media (Internet), speed, symbiosis and complexity. This in turn enables us to rethink what constitutes the foundations of intelligence, knowledge and even life itself. One particularly useful application of network as a concept is the notion of the gift, which is often seen as the archetypical figure for understanding the nature of economics and social relationships.
Culture
Authors: Hutnyk John
Published: June 2006

Culture is considered as a key term in anthropology, now in critical mode, and to be worked through powerful tropes that lead to issues in politics, interpretation, translation, stereotype and racism. Anthropology is described as a cultural system itself, with a large supporting institutional apparatus, not unlike the culture industry as critiqued by Adorno and the Frankfurt School. The high mass culture/high culture distinction is considered and some distortions explained (away). Street culture and culture as (development) resource are evaluated, leading to an assessment of culture as souvenirs, trinkets and the ephemera of tourism as a modern commodity fetish. How this measures up to political struggles is again considered in the light of work by critics such as Fanon and those engaged with anti-imperialist struggles worldwide.
The Enlightenment
Authors: Venn Couze
Published: June 2006

For different reasons, and with different political goals at stake, the fundamental principles advocated by the Enlightenment are being challenged by both the left and the right. This entry sets out to clear a critical space for examining what is at stake in the present in interrogating its legacy as discourse for imagining alternative transmodern and transcolonial futures. A re-evaluation of the Enlightenment by reference to concepts of equality, liberty, emancipation, justice and becoming(s) is central to that task.
The Market
Authors: Cetina Karin Knorr
Published: June 2006

Markets have led a shadowy existence in economics. The ruling paradigm, neoclassical economics, for which markets are a central institution, has mainly been concerned with the determination of market prices. Until recently, sociological investigations of modern markets focused on production, as did anthropological work that ascertained how each culture made a living. The major debate among anthropologists to date has been about whether the economic rationality of the maximizing individual is to be found in all societies or whether substantive economies are always embedded in a cultural matrix that determines its logics and forms of transaction. A new feature of financial markets is that they are based upon scopic systems – electronic and informational mechanisms of observing and contextualizing market reality and of back-projecting this reality onto the computer screens of globally operating traders. When such a mechanism is in place, coordination and activities respond to the reflected, represented reality rather than to pre-reflexive occurrences. This form of coordination contrasts with network forms of coordination that are pre-reflexive in character. In network markets, participants rely on their relationships to determine ‘where the market is’. In a market based on scopic systems, the market is fully visible on screen – as a set of tradable, comprehensively contextualized, quickly moving prices for various trading instruments. In this situation, a level of global inter-subjectivity emerges that derives from the character of these markets as reflexively observed by participants on their computer screens in temporal continuity, synchronicity, and immediacy. As a consequence, these markets are communities of time. As temporalized systems, financial markets project a form of coordination adapted to a global world that leaves behind the patterns of traditional producer and exchange markets.
Genealogies of the Global
Authors: Featherstone Mike
Published: June 2006

The term global suggests all-inclusiveness and brings to mind connectivity, a notion that gained a boost from Marshall McLuhan's reference to the mass-mediated ‘global village’. In the past decade it has rapidly become part of the everyday vocabulary not only of academics and business people, but also has circulated widely in the media in various parts of the world. There have also been the beginnings of political movements against globalization and proposals for ‘de-globalization’ and ‘alternative globalizations’, projects to re-define the global. In effect, the terminology has globalized and globalization is varyingly lauded, reviled and debated around the world. The rationale of much previous thinking on humanity in the social sciences has been to assume a linear process of social integration, as more and more people are drawn into a widening circle of interdependencies in the movement to larger units, but the new forms of binding together of social life necessitate the development of new forms of global knowledge which go beyond the old classifications. It is also in this sense that the tightening of the interdependency chains between human beings, and also between human beings and other life forms, suggests we need to think about the relevance of academic knowledge to the emergent global public sphere.
The Public Sphere
Authors: Eder Klaus
Published: June 2006

The article situates the issue of the public sphere as a phenomenon that is historically bound and culturally specific. According to this point of view, the Western practices and the Western way of thinking about the public sphere appear as a historically particular way of dealing with the more general phenomenon which is the creation of a social bond beyond the family. Looking at the self-contradictory effects of the ‘modern’ Western public sphere, the question is asked whether the public association of self-interested or self-governing individuals might have to be theorized as a partial and insufficient solution to the social bond. A comparative perspective shows that it is not individuals but cultural forms that link people in the public sphere. They do so by providing a narrative basis of discourses and/or markets that in the self-understanding of modernity shape social life.
University
Authors: Wernick Andrew
Published: June 2006

The university is an archaic institution and can claim to have a more or less continuous history over more than two millennia and, at least in the forms that prevail today, could be regarded as a ‘Western’ institution. However, the combination of globalization and cybernation will set the parameters for the next round of the university's development. A trend will be the growth of global universities, both virtual and land-based. At the same time, the growth of professional life outside of and between institutions has lessened dependency on them, and the academic intelligentsia has become interconnected as never before.
Time
Authors: Adam Barbara
Published: June 2006

The article argues that the relationship to time is at the root of what makes us human and that culture arises with and from efforts to transcend death, change and the rhythmicity of the physical environment. Time can be tracked through systems of time measurement and later transformed from a process of nature into clock time, a time to human design that is abstracted from context and content. In this form time can be traded with all other times. With contemporary science and new information and communications technologies, which operate in a new all-encompassing temporal spectrum that extends from nanoseconds to millennia, clock time is no longer appropriate to the associated present-oriented transactions and futures are traversed in the dual sense of the word. By historically locating temporal relations, the article provides both a new understanding of socio-cultural relations and a perspective on social change.
Violence
Authors: Bishop Ryan , W.P. Phillips John
Published: June 2006

Violence is spoken of in several senses but its most basic definition, as a force exerted by one thing on another, harbors serious problems, especially when it comes to a consideration of its source or cause. We begin this article by identifying some of the aporias of violence with reference to philosophical and religious discourses and then we go on to analyze how violence problematizes concepts of law and justice in world historical contexts. We examine several traditions including Indo-European mythology, as well as Hindu, Taoist, and ancient Greek philosophy, before addressing the concept of violence in modern thought, as a revision of Christianity. We conclude with some discussion of epistemological violence and its critics.
Modernity
Authors: Venn Couze , Featherstone Mike
Published: June 2006

Whilst presenting a number of features that have been put forward to characterize modernity as a way of life and a social system, this entry suggests a dissident genealogy that reveals a hidden history of continuities and alternatives. It thereby problematizes the norms about periodization and the assumptions about the elaboration of a logos that underlie the concept of the modern. This approach to modernity as a complex of processes, institutions, subjectivities, and technologies challenges the more familiar history of linear temporalities and progressive transformations. The fruitfulness of seeing modernity, as much as other historical periods, as hybrid assemblages in a state of flux is that it draws attention to the heterogeneity and processual nature of cultures and feeds into the possibility of the critique of the present.
Mutations in Citizenship
Authors: Ong Aihwa
Published: June 2006

Mutations in citizenship are crystallized in an ever-shifting landscape shaped by the flows of markets, technologies, and populations. We are moving beyond the citizenship-versus-statelessness model. First, the elements of citizenship (rights, entitlements, etc.) are becoming disarticulated from each other, and becoming re-articulated with universalizing criteria of neoliberalism and human rights. Such ‘global assemblages’ define zones of political entitlements and claims. Second, the space of the ‘assemblage’, rather than the national terrain, becomes the site for political mobilizations by diverse groups in motion. Three contrasting configurations are presented. In the EU zone, unregulated markets and migrant flows challenge liberal citizenship. In Asian zones, foreigners who display self-enterprising savoire faire gain rights and benefits of citizenship. In camps of the disenfranchised or displaced, sheer survival becomes the ground for political claims. Thus, particular constellations shape specific problems and resolutions to questions of contemporary living, further disarticulating and deterritorializing aspects of citizenship.
Control, Persuasion, and Educational Accountability
Authors: Manna Paul
Published: June 2006

This article examines early implementation of the No Child Left Behind Act's (NCLB) accountability provisions. Theoretically, the author explains how executing education policy in the United States requires federal officials to employ tactics designed to assert control over state implementers while persuading them to adopt federal priorities as their own. Empirically, the main objective is to reveal how control and persuasion have been integral to early federal efforts to keep NCLB on track. The data come from several sources describing state implementation of NCLB and federal efforts to influence state actions during 2002 to 2004. Overall, the author argues that understanding NCLB implementation as a series of control and persuasion challenges confronting federal officials will enable observers to better assess the law's performance.
Needs of Young Children With Cancer During Their Initial Hospitalization: An Observational Study
Authors: Björk Maria , Nordström Berit , Hallström Inger
Published: June 2006

The aim of this study was to describe young (under the age of 7) children’s needs as expressed by their behavior, body language and verbal expression through observations during their initial hospitalization after being diagnosed with cancer. Twelve children under the age of seven were followed during 26 hours with non-participant unstructured observations. Field notes were written after each observation and transcribed into a narrative text, which was analyzed by content analysis at both manifest and latent level. Five themes were identified, of which “need to have the parent close by” was the most prominent. The other themes were “need to play and feel joy,” “need for participation in care and treatment,” “need for a good relationship with the staff,” and “need for physical and emotional satisfaction.” The results indicate that the children needed their parents and the parents’ presence helped the children to express other needs. Professionals need to support the child and his or her parents so that the parents in their turn can support and alleviate their child’s hospitalization and cancer treatment.
Relationships of Age and Gender to Hope and Spiritual Well-Being Among Adolescents With Cancer
Authors: Hendricks-Ferguson Verna
Published: June 2006

The purpose of this study was to examine hope and spiritual well-being, with its 2 dimensions of religious well-being and existential well-being, as they relate to age and gender among adolescents with cancer. A cross-sectional design was guided by the conceptual framework, Adolescent Psychosocial Adaptation to the Cancer Experience. A total of 78 adolescents with a diagnosis of cancer were enrolled from 2 pediatric oncology clinics. Middle adolescents (15-17 years of age) reported higher religious well-being than late adolescents (18-20 years of age). Middle-adolescent boys were more hopeful than were early adolescent boys (13- 14 years of age). Also, girls were more hopeful and reported higher spiritual well-being than age the boys. Developmental phase and/or gender may influence adolescents’ levels of hope, spiritual well-being, religious well-being, and existential well-being as they cope during the cancer experience. The nurse should consider developmental phase and gender when planning interventions to foster hope and spiritual well-being in adolescents’ adaptations to the cancer experience.
Tumor Necrosis in Pediatric Osteosarcoma: Impact of Modern Therapies
Authors: Hendershot Eleanor , Pappo Alberto , Malkin David , Sung Lillian
Published: June 2006

Tumor necrosis following preoperative chemotherapy in patients with osteosarcoma is a predictor of overall survival. With modern therapies, 45% of patients are expected to achieve more than 90% tumor necrosis. Investigators at the authors’ center, however, increasingly noted that patients were experiencing inferior necrosis responses. A retrospective study of treated patients at the center was undertaken to examine this. The purpose of this study was to determine (1) whether the number of patients with favorable histological responses had changed over time and (2) whether the percentage of patients with favorable responses was similar to published outcomes. Chart reviews were performed on patients treated from 1993 to 2003 according to the Pediatric Oncology Group 9351, regimen A protocol. Twenty-one patients met all eligibility requirements; 52% of patients had more than 90% necrosis. No correlation existed between degree of necrosis and year of treatment (r = 0.06; P = .8). Patients with osteosarcoma treated at the authors’ institution have comparable tumor necrosis responses to published outcomes, and no change occurred over time. This study stresses the importance of rigorous retrospective reviews before implementing treatment changes.
A Comparison of Field Methods to Assess Cardiorespiratory Fitness Among Neophyte Exercisers
Authors: D’Alonzo Karen T. , Marbach Kate , Vincent Linda
Published: June 2006

There is evidence to suggest that aerobic fitness levels among adults have declined markedly over the past 2 to 3 decades. Submaximal field measures of aerobic fitness, such as step tests, may now be seen as aversive by contemporary neophyte exercisers. In this study, a single-factor within-subjects (repeated measures) factorial design was used to compare three field measures of cardiorespiratory fitness among sedentary women: (a) the Queen’s College step test (QCST), (b) the Rockport 1-mile walk (RW), and (c) a nonexercise estimation of VO 2 max (NE). The sample consisted of 31 racially and ethnically diverse female college students (mean age of 24.8 years). No significant within-subjects differences were found in the three measures of V0 2 max (F = 1.89, p = .17) among Black, Hispanic, White non-Hispanic, or Asian women, but relative perceived exertion scores were significantly higher for the QCST than for the RW (t = 9.79, p < .001) for all groups. The mean calculated VO 2 max for the QCST was 35.90 ml/kg/min for the subset of women ages 18 to 25 and 31.85 for those ages 26 to 46. These values represent a “poor” to “below average” score for aerobic capacity among women in both age groups. Data from this preliminary study suggest that both the RW test and the NE test are comparable to the QCST as valid and reliable field measures of aerobic fitness and appear to be good alternatives to step testing among sedentary individuals.
Medical Record Versus Researcher Measures of Height and Weight
Authors: DiMaria-Ghalili Rose Ann
Published: June 2006

This study examined the extent of agreement between medical record and researcher measures of height and weight in adults and assessed the clinical significance of any resulting differences in body mass index (BMI) (kg/m 2 ) according to the categorizations of underweight, normal weight, and overweight. Medical record and researcher measurements for height (n = 85), preoperative weight (n = 84), and postoperative weight (n = 65) in older patients undergoing elective coronary artery bypass grafting were used for analysis. Researcher measurements of height and weight were obtained by the same person and were compared to height and weight measurements extracted from the medical record. Bland and Altman’s limits of agreement method was used to determine the extent of measurement error between medical record and researcher values. Cohen’s kappa was used to assess for clinical significance of the differences in BMI categories based on medical record and researcher measurements. For height, 7% of the values were outside the 95% limits of agreement. For preoperative and postoperative weight, less than 5% of the values were outside the 95% limits of agreement. There were no significant differences in BMI categorization using Cohen’s kappa between medical record and researcher measurements. Although there may be some measurement error for height in the medical record, weight measurements may have less error and the amount of measurement error may not be clinically relevant. Height and weight measurements extracted from the medical record are reliable and accurate in patients admitted for elective surgery, as are weight measurements obtained in stable postoperative patients.