bluuebunny/crossref_metadata_2025 huggingface dataset:
ЧАСТОТНО-РЕГУЛИРУЕМЫЙ ЭЛЕКТРОПРИВОД ЦЕНТРОБЕЖНЫХ НАСОСНЫХ УСТАНОВОК ДОБЫЧИ НЕФТИ
Authors: Чернышева Татьяна Александровна , Аникин Василий Владимирович , Чернышев Игорь Александрович , Чернышев Александр Юрьевич
Published: December 2019

Актуальность работы обусловлена необходимостью снижения аварийности частотно-регулируемых асинхронных электроприводов центробежных насосных установок добычи нефти вследствие перегрева асинхронных двигателей. Цель: исследовать частотно-регулируемые электроприводы центробежных насосных установок добычи нефти, работающих при скорости выше номинальной. Методы исследования основаны на использовании теории автоматического управления и имитационного моделирования в программной среде MatLab-Simulink. Результаты. Составлена схема имитационного моделирования скалярного частотно-регулируемого асинхронного электропривода центробежных насосных установок добычи нефти, учитывающая основные особенности реального электропривода. Расcчитаны механические характеристики электропривода насосной установки. Определены возможные диапазоны регулирования скорости электропривода насосной установки исходя из допустимых потерь мощности в установившихся и переходных режимах. Выводы. Несмотря на то, что статическая механическая характеристика электропривода с частотой напряжения преобразователя 30 Гц является минимально возможной для добычи нефти с помощью погружных насосов, диапазон регулирования скорости в асинхронном электроприводе погружного насоса необходимо расширить до D=1:10 для плавного пуска электропривода. Установлено, что для уменьшения ударных моментов при пуске асинхронного частотно регулируемого электропривода темп роста частоты на выходе задатчика интенсивности должен составлять несколько десятков секунд даже при пуске на минимальную рабочую скорость электропривода. Неизбежное завышение по мощности асинхронного двигателя для погружного центробежного насоса при его выборе как ближайшего большего из ряда номинальных значений позволяет электроприводу насоса с частотным регулированием скорости работать без перегрева на статических характеристиках выше номинальной. Установлено, что в частотно-регулируемом асинхронном электроприводе центробежного насоса возможное повышение скорости на 10–12 % от номинальной позволяет увеличить объем добычи нефти без замены оборудования.
METAFORE ISTINE U SRPSKOM JEZIKU
Authors: Jovanović Jovana
Published: December 2019

Predmet istraživanja jeste ispitivanje konceptualizacije apstraktnog pojma leksikalizovanog kao istina i utvrđivanje pojmovnih metafora kao mehanizama mišljenja. Na temelju postulata kognitivne lingvistike istražuju se osnovni izvorni domeni u kojima se konceptualizuje istina kao apstraktni pojam (entitet, biljka, životinja, osoba i sl.). Istraživanje se obavlja na Elekstronskom korpusu srpskog jezika (SrpKorp), iz kojeg će se ekscerpirati trista različitih primera koji sadrže datu leksemu (posmatraće se minimalni kontekstualni spojevi apstraktne imenice istina sa predikatima fizičke radnje, deskriptivnim pridevima i konkretnim imenicama) pri čemu će se posmatrati i funkcionalnostilska pripadnost izdvojenih primera. Izvršiće se statistička analiza, koja podrazumeva uvid u frekvenciju izvornih domena. Ukazaće se na elemente u konceptualizaciji značenja datog pojma koji otkrivaju osobenosti duha i kulture nosilaca srpskog jezika. Istraživanje počiva na postulatima konceptualne metode, jednog od krucijalnih alata za ispitivanje značenja u kognitivnoj lingvistici.
ПОРЕДБЕНЕ КЛАУЗЕ СА ЗНАЧЕЊЕМ ЕКВАТИВНОСТИ У РОМАНУ ЂАКОН БОГОРОДИЧИНЕ ЦРКВЕ ИСИДОРЕ СЕКУЛИЋ
Authors: Степанов Маја
Published: December 2019

У раду се анализирају поредбене клаузе са значењем еквативности и њихови кондензатори у роману Ђакон Богородичине цркве Исидоре Секулић. Централни део рада посвећен је клаузама с везником као што, као да или речцом као која је кондензатор клаузе с једним од ова два везника. Описана су основна граматичка обележја анализираних клауза и указано је на њихове поједине семантичке специфичности. У другом делу рада анализиране су и клаузе са везницима како, какав и колико које убрајам у поредбене клаузе са значењем еквативности. У закључку су дати подаци о заступљености сваког појединачног поредбеног везника у корпусу.
УСВАЈАЊЕ ПЕРИФРАСТИЧНИХ КОНСТРУКЦИЈА У СРПСКОМ ЈЕЗИКУ КАО СТРАНОМ
Authors: Дражић Јасмина , Ајџановић Јелена
Published: December 2019

Перифрастични предикатски изрази представљају посебну врсту реченичних јединица које се садржински и формално често не подударају на међујезичком плану (нпр. срп. постићи договор : пољ. dojść do porozumienia : енгл. to reach an agreement). Њихова лексикографска обрада такође је неуједначена и често неадекватна, што студентима којима је српски језик Л2 отежава идентификацију и претраживање у постојећим дескриптивним речницима. Стога, као један од основних задатака теоретичара и практичара у домену наставе страних језика издваја се идентификација оваквих структура и осветљавање њихових значења на основу семантике именичке речи као значењског тежишта тих фраза. Циљ овога рада јесте да се на примерима семантичке скупине глагола са компонентом ‘резултативност’ /+/ испитају следећи феномени: (а) селекција глаголских лексема и њихових комплемената, (б) предлог за презентацију оваквих спојева у настави српског језика као страног и (в) нацрт њихове лексикографске обраде.
YAKINSAMA (CONVERGENCE ) VE ÇAPRAZ MEDYA (CROSSMEDIA) STRATEJİSİNİN MEDYA SEKTÖRÜNDE YANSIMALARI
Authors: YOLOĞLU Nurhayat
Published: December 2019

1990’lı yıllara kadar
medya sektörünün en önemli sorunlarının başında yer alan, yeni sunucuların
medya pazarına girişi gibi sorunların nedenlerinden biri olarak gösterilen
teknik engeller, günümüzde taşıyıcı ağların dijitalleşmesi sayesinde ortadan
kalkmaya başlamıştır. Bu bağlamda dijitalleşme, çoklu medya ortamlarının
gerçekleştiği medya sektöründe yaşanılan büyük değişimlerin temel aktörü olarak
değerlendirilebilir. Medya sektörünün yoğun bir biçimde yararlandığı yakınsak
teknoloji, kendi içinde yakınsama ve çapraz medya gibi yeni kavramların ve
bunlara bağlı stratejilerin gelişmesine katkıda bulunmuştur. Bu çalışmanın
amacı Türkçemize “yakınsama” ve “çapraz medya” olarak çevrilen “Convergence” ve
Crossmedia” iletişim stratejisi kavramlarının medya sektöründeki yansımalarını
incelemektir. Çalışma yöntemi olarak nitel araştırma yöntemi kullanılmış ve
betimsel bir çalışma yapılmıştır. Çalışma sonucunda ortaya çıkan bulgulara
göre, etimolojik olarak birbirleriyle uyumlu olmayan bu iki kavramın, uygulama
alanlarında bazı etiksel ve hukuksal yansımaları bulunduğu, bu çerçevede lehte
ve aleyhte bir takım görüşler olduğu saptanmıştır. Örneğin, çapraz medya yakınsamasının aleyhinde olan görüşlerin
temelinde; medyada çoklu editoryal yapının, çok sesliliğin kaybına neden
olacağı düşüncesi yatmaktadır.
Prevenção do consumo de bebida alcoólica durante a gestação: atuação de enfermeiras no pré-natal
Authors: Caires Tharine Louise Gonçalves , Santos Rosângela Da Silva , Ribeiro Liliane Da Consolação Campos
Published: December 2019

Objetivo: compreender a atuação de enfermeiras, em consultas de pré natal, no que tange à prevenção do consumo de bebida alcoólica por gestantes. Método: trata-se de uma pesquisa qualitativa, que utilizou o método Narrativa de Vida. Os dados foram coletados por meio de entrevista aberta e gravada com enfermeiras responsáveis por equipes de saúde. Resultados: os resultados apontaram que as mulheres omitem o consumo de álcool, em consultas de pré-natal, e as enfermeiras entrevistadas não possuem estratégias capazes de detectar esse consumo. Não tiveram formação profissional, para esse atendimento e concordam que beber socialmente não acarreta prejuízos à gestante e ao feto. O consumo de bebidas alcoólicas pelas gestantes está subdiagnosticado por profissionais que atuam no serviço de pré-natal e, quando diagnosticado, não é registrado nos prontuários. Conclusão: o estudo contribuiu, para ampliar a discussão sobre a importância da prevenção do consumo de álcool por gestantes, durante a consulta de pré-natal realizada pelas enfermeiras, a necessidade de instrumentalizá-las sobre esta temática, durante a sua formação profissional e, para incentivar o desenvolvimento de pesquisas nessa área, de modo a melhor subsidiar a atuação dos profissionais de saúde junto às gestantes.
Vivência das famílias e o custo no cuidado de crianças e adolescentes com mielomeningocele
Authors: Freitas Giselle Lima de , Faleiros Fabiana , Silva Kênia Lara
Published: December 2019

Objetivo: Compreender as vivências das famílias e o custo ao cuidado de crianças e adolescentes com mielomeningocele. Método: Pesquisa exploratória realizada com 16 famílias de crianças e adolescentes com mielomeningocele usuários de um Hospital de Reabilitação de Belo Horizonte/MG. Para a coleta de dados, utilizaram-se a entrevista e a observação, durante as três visitas domiciliares, realizadas em cada família participante. Resultados: A renda familiar média foi de dois salários mínimos. O baixo nível socioeconômico foi agravado pelas dificuldades à aquisição gratuita de materiais para a realização dos cuidados. Os custos diretos com os cuidados relacionaram-se à compra de medicamentos, fraldas, cateteres urinários e gastos com transporte, sendo menores para as famílias de adolescentes independentes. Conclusão: Os pais de crianças em condições crônicas vivenciam barreiras econômicas e sociais relacionadas ao custo do cuidado em domicílio e necessitam de suporte com serviços de atenção primária e de reabilitação.
Avaliação do diagnóstico de enfermagem “dor aguda” em pacientes internados em uma clínica médico-cirúrgica
Authors: Boscarol Gabriela Tavares , Domingos Camila Santana , Souza Cristiane Chaves de , Tannure Meire Chucre , Chianca Tânia Couto Machado , Salgado Patrícia Oliveira
Published: December 2019

Objetivo: avaliar o diagnóstico de enfermagem “Dor aguda” em pacientes internados, em uma unidade de clínica médico-cirúrgica, a partir do uso de um software. Método: estudo quantitativo do tipo transversal, observacional e descritivo com pacientes internados em uma unidade de clínica médico-cirúrgica masculina e feminina de um hospital de ensino. A amostra foi composta por 100 pacientes. Os dados foram coletados por meio de entrevista previamente estruturada em um software. Na análise descritiva dos dados, calculou-se a taxa de prevalência e correlação de Pearson. Considerou-se nível de significância de 5%. Resultados: prevalência de 34% do diagnóstico de enfermagem “Dor aguda”. A maioria dos pacientes tinha menos que 60 anos e era do sexo masculino. Nas últimas avaliações, 21 (61,8%) pacientes mantiveram queixa de dor, sobretudo, relacionada a procedimentos cirúrgicos e traumas. Verificou-se que a proporção de homens foi maior que a de mulheres na queixa de dor leve e moderada. Quanto maior o tempo de internação maior foi o número de pacientes com a queixa de dor resolvida (r= 0,384; p= 0,025). Conclusão: os dados deste estudo corroboram com os achados de outros autores no que tange à importância da avaliação da dor e intervenções adequadas em seu manejo.
Relações interpessoais no centro cirúrgico: equipe de enfermagem e equipe médica
Authors: Salimena Anna Maria Oliveira , Peixoto Raquel Santos Rosa , Araújo Silvia Teresa Carvalho , Alves Marcelo Silva
Published: December 2019

Objetivo: Compreender significados e desvelar sentidos da equipe de enfermagem em centro cirúrgico nas suas relações interpessoais com a equipe médica. Método: Pesquisa de natureza qualitativa, embasada no referencial teórico, filosófico e metódico na fenomenologia Heideggeriana. Participaram 17 profissionais da equipe de enfermagem de um centro cirúrgico, entre os meses de outubro de 2016 a janeiro de 2017, utilizando a entrevista fenomenológica norteada pela questão: Como você significa as suas relações interpessoais com a equipe médica no seu trabalho?. Dos depoimentos emergiram as estruturas essenciais, a construção do conceito de ser e a unidade de significado, possibilitando desvelar os sentidos dos profissionais. Resultado: Os profissionais de enfermagem significaram as relações interpessoais com a equipe médica como boa, mas com conflitos e divergências. Foram desvelados os sentidos ser-com, impropriedade, inautencidade, ambiguidade e distanciamento. Considerações Finais: Dos sentidos desvelados considera-se imprescindíveis que as relações interpessoais estabelecidas sejam harmônicas, baseadas na empatia, respeito e comunicação eficaz a fim de garantir uma assistência segura ao paciente.
Análise de custos do tratamento de lesão por pressão em pacientes internados
Authors: Vieccelli Donoso Miguir Terezinha , Barbosa Sara Almeida Souza , Simino Giovana Paula Resende , Couto Braulio Roberto Gonçalves Marinho , Ercole Flavia Falci , Barbosa Jaqueline Almeida Guimarães
Published: December 2019

Objetivo: Avaliar o custo do tratamento de lesões por pressão em pacientes internados, relacionado a materiais de curativos e mão de obra do profissional de enfermagem. Método: estudo transversal, descritivo, com dados secundários de análise de custos diretos com materiais de curativos no tratamento de lesões por pressão, realizado em hospital de médio porte, de ensino, no estado de Minas Gerais. A amostra foi não probabilística, totalizando 60 participantes. Resultados: em relação aos custos com tratamento de lesão por pressão, observou-se média de custo semestral de R$ 1.886,00 por paciente e, custo total de R$ 113.186,00. Quanto ao custo com profissionais da enfermagem, a maioria dos pacientes teve custo máximo de R$ 1.000. Conclusões: a avaliação da população e dos custos indicou que o tratamento de lesão por pressão acarreta custos elevados e onera as instituições de saúde. Medidas preventivas, quando possível, devem ser otimizadas, resultando em economia para a instituição.
Distresse e bem-estar psicológico em estudantes da graduação em enfermagem do Brasil e Portugal
Authors: Vieira Maria Theresa Da Silva , Lessa Ingrid Dos Santos , Luiz Franciane Silva , Santos Kelli Borges dos , Matos Filomena Adelaide Pereira Sabino de , Carbogim Fábio Da Costa
Published: December 2019

Objetivo: avaliar e comparar os níveis de distresse e bem-estar psicológico dos estudantes da graduação de Enfermagem do Brasil e Portugal. Método: trata-se de um estudo transversal, realizado com 267 estudantes do primeiro ao quarto ano de graduação de enfermagem, no Brasil e Portugal. Para análise dos dados, utilizou-se frequência absoluta, frequência relativa e média. A associação entre as variáveis qualitativas, pelo teste Qui-Quadrado. Resultados: os estudantes brasileiros são mais ansiosos, depressivos e perdem com maior frequência o controle emocional, enquanto os estudantes de Portugal apresentam maior bem estar psicológico. Estudantes do início do curso, brasileiros e do sexo feminino apresentavam maior média para a variável distresse. Conclusão: esforços são necessários para auxiliar os estudantes, no gerenciamento dos níveis de distresse, a partir do planejamento acadêmico, estímulo à inserção em atividades de laser e a lidar de forma resiliente com o universo acadêmico.
Aquisição de habilidades e competências para cuidar em saúde mental: autoavaliação de estudantes de enfermagem
Authors: Lemos Aline Mesquita , Lima Helder De Pádua , Alves Maria Dalva Santos , Souza Ângela Maria Alves e , Aguiar Maria Isis Freire de , Araújo Michell Ângelo Marques
Published: December 2019

Objetivo: identificar como estudantes de enfermagem avaliam a aquisição de habilidades e competências para o cuidado em saúde mental. Métodos: estudo descritivo, transversal, realizado com 73 estudantes de enfermagem. Os dados foram coletados, por meio de questionário e apresentados em tabelas. Analisou-se a associação entre períodos de curso, observação da prática do cuidado de enfermagem em saúde mental, e aquisição de habilidades e competências para tal prática, por meio dos testes qui-quadrado de Pearson e razão de verossimilhança. Resultados: houve associação entre períodos de graduação em curso e observação das práticas de lidar com paciente em crise (p=0,064) e aplicar a Assistência de Enfermagem em Saúde Mental no contexto comunitário (p=0,097); a aquisição das habilidades de reconhecer preceitos da Política Nacional de Saúde Mental (p=0,021) e aplicar a Sistematização da Assistência de Enfermagem junto à pessoa com transtorno mental (p=0,051); e a aquisição das competências caracterizar transtornos mentais (p=0,013) e atuar no nível de atenção primária à saúde mental (p=0,001). Conclusão: diante das lacunas identificadas na aquisição de habilidades e competências para o cuidado de enfermagem, em saúde mental, por parte de estudantes, ressalta-se a necessidade de reforçar a formação em enfermagem em saúde mental por competências e habilidades.
Histomorphology of Pancreatic Islet in Physiological Aging Female Rats Post Intravenous Human Wharton’s Jelly Mesenchymal Stem Cell Injection
Authors: Astini Wining
Published: December 2019

The increasing population of aged people will have the important role in the life, but the function of their bodies will decrease because of aging. Aging will increase the risk of degenerative disease, one of example is diabetes. The disease is related to the aging in the pancreatic organ which progressively declines by age. The aimed of the experiment was to determine the effect of human wharton’s jelly mesenchymal stem cells by injecting intravenously in aging female rats. This study used 3 young female rats (3 months) and 6 aging female rats (24 months). The experiment consisted of three groups. The young control group (A), the aging control group (B) that received NaCl (0.9%) 0,4 mL, the aging treatment group (C) received 1 x 106 cells/kg of human wharton’s jelly mesenchymal stem cells 0,4 mL. The aging control and the aging treatment group were injected 4 times with the interval in 3 months. The end of the experiment (12 months), the rats were anesthetized and sacrificed. The pancreatic tissues were collected to examine the pancreatic islets by histology studies. Changes of the pancreatic islet in control and treated groups were examined using hematoxylin and eosin staining. These findings conclude that injecting human wharton’s jelly mesenchymal stem cell increase the diameter and total pancreatic islet in the treatment group. In other side, the cell population of pancreatic islet also have significant differences (P<0.05) in treated physiological aging female rat groups than control aging female rat group.
Indirect estimation of infant mortality in small areas
Authors: Neupert Ricardo , Fernandez Menjivar Rogelio Eduardo , Fernandez Castilla Rogelio Eduardo
Published: December 2019

The Brass-type indirect methods of early-age mortality estimation have been used for more than four decades, providing very robust estimates for countries without reliable vital registration systems. However, when estimation areas become smaller, the number of dead children could be very small, especially among those born to young women, who provide essential information to estimate recent mortality. In these cases, estimates could be affected by random errors and unexpected annual fluctuations. At the same time, although it is very unlikely that demographic trends in a small area would follow patterns very different from those prevailing in the broader environment they belong to, it is possible that some local events may become relevant to small areas, causing some deviations from the assumptions that may hold true to the larger area. The objective of this paper is to propose an adaptation of the indirect estimation approach, which would allow obtaining infant and child mortality estimates for small areas. As such, this proposal belongs to the realm of indirect estimation methods, sharing the limitations and advantages that characterize this type of estimation procedures. The method is illustrated with data from the 2014 Population and Housing Census of Myanmar. The results indicate that the method proposed here provides reliable and consistent infant mortality estimates, compared to the original Brass’ method, even in very small areas.
Persepsi dan Sikap Mahasiswa terhadap Rubrik Gizi dan Kesehatan di Media Massa (Studi pada Mahasiswa FIK-UNJ dalam Mempersepsi Rubrik Gizi dan Kesehatan di Beberapa Media Massa)
Authors: Wasan Aan
Published: December 2019

Abstrak. Tujuan dari penelitian ini adalah untuk mengetahui persepsi dan sikap mahasiswa terhadap rubrik gizi dan kesehatan yang muat di media cetak. Metode yang digunakan adalah metode survei dengan disain penelitian deskriptif analisis. Penelitian dilakukan di Kampus Fakultas Ilmu Keolahragaan (FIK), Universitas Negeri. Pemilihan lokasi dilakukan secara sengaja (purposive) dengan pertimbangan,mahasiswa FIKmemiliki intensitas gerak yang tinggi. Meski demikian, intensitas dengan media massa yang menyajikan tulisan tentang gizi dan kesehatan, jarang mereka lakukan. Hasilnya menunjukkan bahwa seluruh mahasiswa yang berjenis kelamian perempuan yang menjadi responden dalam penelitian ini, memiliki persepsi baik terhadap rubrik gizi dan kesehatan yang disajikan media massa terbitan Jakarta. Sedangkan, mahasiswa yang berjenis kelamin laki-laki yang menjadi reponden, memiliki persepsi yang berbeda, dimana 50 persen berpersepsi baik dan 50 persen berpersepsi sedang terhadap rubrik gizi dan kesehatan ini. Sedangkan sikap mereka terhadap rubrik tersebut, dapat dijelaskan bahwa seluruh responden perempuan bersikap positif terhadap. Dengan demikian, 75 persen responden memiliki persepsi positif terhadap rubrik tersebut, sedangkan sisanya atau 25 persen berpersepsi sedang. Hasil penenilian ini juga menjelaskan tentang sikap responden, dimana 25 persen laki-laki memiliki sikap baik terhadap rubrik tersebut dan sisanya atau 75 persennya bersikap netral. Sementara itu, responden perempuan semuanya atau 100 persen memiliki sikap baik terhadap rubrik gizi dan kesehatan yang dimuat di media massa cetak.

Kata Kunci: Persepsi, Sikap, Rubrik kesehatan.
Perbandingan Latihan Otot Isotonik dan Isometrik terhadap Peningkatan Kekuatan Otot Quadriceps Femoris pada Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta
Authors: Yanuarfiqri Aldira Madyansyah , Purba Ruliando Hasea , Dewanti Rina Ambar
Published: December 2019

Abstrak.Tujuan penelitian ini adalah untuk mendapatkan hasil peningkatan kekuatan otot quadriceps femoris mahasiswa program studi Ilmu Keolahragaan Universitas Negeri Jakarta angkatan 2015, yaitu dengan menggunakan metode latihan isotonik dan metode latihan isometrik. Selain itu, juga mencari dan menemukan metode mana yang lebih signifikan dalam memberikan kontribusi pada hasil peningkatan kekuatan otot quadriceps femoris.

Penelitian ini merupakan penelitian kuantitatif dengan metode eksperimen. Jumlah populasi pada penelitian ini adalah seluruh Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta Angkatan 2015 dan sampel pada penelitian ini adalah Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta Angkatan 2015 yang diambil dengan metode purposive sampling. Data dikumpulkan dan diolah menggunakan metode uji T-Independen. Sampel dilibatkan dalam prosedur eksperimen pre-post two group design dengan 16 kali sesi latihan menggunakan Leg Extension Machine.

Hasil penelitian menunjukan bahwa terjadi peningkatan hasil kekuatan otot quadriceps femoris setelah diberikan latihan dengan mengunakan metode isotonik dengan nilai t-hitung 15,16 Lebih besar dari nilai t-tabel 2,262. Selain itu, juga terjadi peningkatan hasil kekuatan otot quadriceps femoris setelah diberikan latihan dengan menggunakan metode isometrik dengan nilai t-hitung 17,15 lebih besar dari nilai t-tabel 2,262. Selain itu juga terjadi peningkatan otot lebih besar pada metode latihan isotonik disbanding metode latihan isometrik dengan nilai t-hitung 2,375 lebih besar dari t-tabel 2,101.

Kata Kunci : Kekuatan otot, Kontraksi otot, Metode latihan penguatan.
Liposclerosing Myxofibrous Tumor in a Patient with Prostate Cancer
Authors: Barnds Brandon , Grote Caleb , Mettman Daniel , Templeton Kimberly
Published: December 2019

Case:

A 64-year-old man diagnosed with prostate cancer was incidentally found to have a lesion in his distal femur. Although initially concerning for metastatic prostate cancer, after biopsy by an orthopaedic oncology specialist, a diagnosis of liposclerosing myxofibrous tumor (LSMFT) was confirmed. The lesion was treated with curettage and demineralized bone matrix grafting with close follow-up.

Conclusions:

This case report illustrates that LSMFT is not confined to the proximal femur and highlights the differences in radiographic appearance between LSMFT and more common metastatic bone lesions.
Strengthening Community-Clinical Linkages to Reduce Cardiovascular Disease Risk in Rural NC: Feasibility Phase of the CHANGE Study
Authors: Samuel-Hodge Carmen D , Gizlice Ziya , Allgood Sallie D , Bunton Audrina J , Erskine Amber , Leeman Jennifer , Cykert Samuel
Published: December 2019

Background Community Health Workers (CHW) are recommended for delivery of interventions to prevent cardiovascular disease, but there is insufficient evidence to guide implementation of CHW interventions in rural, medically underserved areas.Methods Using a hybrid implementation-effectiveness design, we evaluated the implementation and effectiveness of an adapted, evidence-based cardiovascular disease risk reduction intervention among rural high-risk adults. CHWs at a community health center and local health department recruited, enrolled and counseled participants during 4 monthly home visits and 3 brief phone contacts. Participant data collection included pre- and post-intervention measurements of blood pressure, weight, and dietary and physical activity behaviors. We evaluated implementation with measures of intervention reach and delivery fidelity. Statistical analyses included descriptive statistics and paired t-tests.Results Study participants (n=105) had a mean age of 62 years and included 88% Non-Hispanic Blacks and 82% females. Recruitment strategies resulted in the enrollment of 38% of interested and eligible participants who received 80% of the planned intervention visits and phone contacts. Mean differences in pre-/post-intervention measures showed significant mean reductions in blood pressure (-5.4 mm Hg systolic, p=.006; -2.3 mm Hg diastolic, p=.04) and body weight (-3.8 lb., p=.02). Self-reported dietary and physical activity behaviors also improved significantly.Conclusion This feasibility study demonstrated preliminary implementation and program effectiveness of a CHW-delivered intervention to reduce cardiovascular disease risk factors. Additionally, it identified areas for future refinements to strategies that strengthen community-clinical linkages with an integrated role of CHWs in rural health care delivery. If results from this feasibility study can be enhanced in a larger sample, there would be significant potential to positively impact the excess burden of chronic diseases that adversely impact rural, low-income, and medically underserved populations.
Cost-Effectiveness of Pain Management Services for Chronic Low Back Pain: A Systematic Review of Published Studies
Authors: Almazrou Saja , Elliott Rachel A , Knaggs Roger D , AlAujan Shiekha S
Published: December 2019

Background: Chronic low back pain (CLBP) is a highly prevalent condition that has substantial impact on patients, the healthcare system and society. Pain management services (PMS), which aim to address the complex nature of back pain, are recommended in clinical practice guidelines to manage CLBP. Although the effectiveness of such services has been widely investigated in relation to CLBP, the quality of evidence underpinning the use of these services remains moderate. Therefore the aim is to summarize and critically appraise the current evidence for the cost effectiveness of pain management services for managing chronic back pain. Methods: Electronic searches were conducted in MEDLINE, EMBASE and PsycINFO from their inception to February 2019. Full economic evaluations undertaken from any perspective conducted alongside randomized clinical trials (RCTs) or based on decision analysis models were included. Cochrane Back Review Group (CBRG) risk assessment and the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist were used to assess the methodological quality of eligible studies. Results: Five studies fulfilled eligibility criteria. The interventions varied significantly between studies in terms of the number and types of treatment modalities, intensity and the duration of the program. Interventions were compared with either standard care, which varied according to the country and the setting; or to surgical interventions. Three studies showed that pain management services are cost effective, while two studies showed that these services are not cost effective. In this review, three out of five studies had a high risk of bias based on the design of the randomised controlled trials (RCTs). In addition, there were limitations in the statistical and sensitivity analyses in the economic evaluations. Therefore, the results from these studies need to be interpreted with caution. Conclusion Pain management services may be cost effective for the management of low back pain. However, this systematic review highlights the variability of evidence supporting pain management services for patients with back pain. This is due to the quality of the published studies and the variability of the setting, interventions, comparators and outcomes.
Effectiveness of the Healthy Start-Départ Santé approach on physical activity, healthy eating and fundamental movement skills of preschoolers attending childcare centres: A randomized controlled trial
Authors: Leis Anne , Ward Stéphanie , Vatanparast Hassan , Humbert Louise , Chow Amanda Froehlich , Muhajarine Nazeem , Engler-Stringer Rachel , Bélanger Mathieu
Published: December 2019

Background: Since young children spend approximately 30 hours per week in early childcare centres (ECC), this setting is ideal to foster healthy behaviors. This study aimed to asses the effectiveness of the Healthy Start-Départ Santé (HSDS) randomized controlled trial in increasing physical activity (PA) levels and improving healthy eating and fundamental movement skills in preschoolers attending ECC. Methods: Sixty-one ECC were randomly selected and allocated to either the usual practice (n=30; n=433 children) or intervention group (n=31; n=464 children). The HSDS intervention group was provided a 3-hour on-site training for childcare educators which aimed to increase their knowledge and self-efficacy in promoting healthy eating, PA and development of fundamental movement skills in preschoolers. PA was measured during childcare hours for five consecutive days using the Actical accelerometer. Preschoolers’ fundamental movement skills were assessed using the standard TGMD-II protocol and POMP scores. Food intake was evaluated using digital photography-assisted weighted plate waste at lunch, over two consecutive days. All data were collected prior to the HSDS intervention and again 9 months later. Mixed-effect models were used to analyse the effectiveness of the HSDS intervention on all outcome measures. Results: Total number of children who provided valid data at baseline and endpoint for PA, food intake and fundamental movement skills were 259, 670 and 492, respectively. Children in the HSDS intervention group had, on average, a 3.33 greater point increase in their locomotor motor skills scores than children in the control group (β=3.33, p=0.009). No significant differences in effects were observed for object control, PA and food intake. However, results demonstrated a marginal increase in portions of fruits and vegetables served in the intervention group compared to control group (β=0.06, p=0.05). Conclusion: Locomotor skills showed a significant improvement in the intervention group compared to the control one. Although modest beneficial effects of HSDS were found, most outcome indicators progressed in a direction favouring the HSDS intervention compared to the usual practice group.
Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus
Authors: Chia Catherine , Inoguchi Noriko , Varon Kyle C. , Bartholomai Bradley M. , Moriyama Hideaki
Published: December 2019

Objective The nuclear and mitochondrial genomes of Dictyostelium discoideum , a unicellular eukaryote, have relatively high A+T-contents of 77.5% and 72.65%, respectivey. To begin to investigate how the pyrimidine biosynthetic pathway fulfills the demand for dTTP, we determined the catalytic properties and structure of the key enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) that hydrolyzes dUTP to dUMP, the precursor of dTTP. Results The annotated genome of D. discoideum identifies a gene encoding a polypeptide containing the five conserved motifs of homotrimeric dUTPases. Recombinant proteins, comprised of either full-length or core polypeptides with all conserved motifs but lacking residues 1-37 of the N-terminus, were active dUTPases. Crystallographic analyses of the core enzyme indicated that the C-termini, normally flexible, were constrained by interactions with the truncated N-termini. This allowed greater access of dUTP to active sites, resulting in enhanced catalytic parameters. A tagged protein comprised of the N-terminal forty amino acids of dUTPase fused to green fluorescent protein (GFP) was expressed in D. discoideum cells. Supporting a prediction of mitochondrial targeting information within the N-terminus, localization and subcellular fractionation studies showed GFP to be in mitochondria. N-terminal sequencing of immunoprecipitated GFP revealed the loss of the dUTPase sequence upon import into the organelle.
An artificially simulated outbreak of a respiratory infectious disease
Authors: Author) Zuiyuan Guo(Former Corresponding , Xu Shuang , Tong Libo , Dai Botao , Author) Yuandong Liu(New Corresponding , Dan Xiao
Published: December 2019

Background Outbreaks of respiratory infectious diseases often occur in crowded places. To understand the pattern of spread of an outbreak of a respiratory infectious disease and provide a theoretical basis for targeted implementation of scientific prevention and control, we attempted to establish a stochastic model to simulate an outbreak of a respiratory infectious disease at a military camp. This model fits the general pattern of disease transmission and further enriches theories on the transmission dynamics of infectious diseases.Methods We established an enclosed system of 500 people exposed to adenovirus type 7 (ADV 7) in a military camp. During the infection period, the patients transmitted the virus randomly to susceptible people. The spread of the epidemic under militarized management mode was simulated using a computer model named “the random collision model”, and the effects of factors such as the basic reproductive number (R0), time of isolation of the patients (TOI), interval between onset and isolation (IOI), and immunization rates (IR) on the developmental trend of the epidemic were quantitatively analysed. Results Once the R0 exceeded 1.5, the median attack rate increased sharply; when R0=3, with a delay in the TOI, the attack rate increased gradually and eventually remained stable. When the IOI exceeded 2.3 days, the median attack rate also increased dramatically. When the IR exceeded 0.5, the median attack rate approached zero. The median generation time was 8.26 days, (95% confidence interval [CI]: 7.84-8.69 days). The partial rank correlation coefficients between the attack rate of the epidemic and R0, TOI, IOI, and IR were 0.61, 0.17, 0.45, and -0.27, respectively. Conclusions The random collision model not only simulates how an epidemic spreads with superior precision but also allows greater flexibility in setting the activities of the exposure population and different types of infectious diseases, which is conducive to furthering exploration of the epidemiological characteristics of epidemic outbreaks.
Predictors of multimorbidity among the Kurdish population living in the Northwest of Iran
Authors: Aminisani Nayyereh , Rastgou Laven , Shamshirgaran Seyed Morteza , Sarbakhsh Parvin , Ghaderi Shadi , Hyde Martin
Published: December 2019

Background: There is limited information about the predictors of multimorbidity (MM) among ethnic minority older adults in Iran. This study aimed to examine the impact of sociodemographic and lifestyle factors on the prevalence of MM, among older Kurdish people living in the Northwest of Iran. Methods: The current study was conducted in Bukan city located in West Azarbaijan province in the Northwest of Iran. Stratified random sampling was used to select people aged 50 + from eight health centres in Bukan from Oct 2017 to Dec 2018. Those who accepted the invitation and completed the baseline questionnaire were included in this study (N=1493; Response rate 75%). A range of different factors, including sociodemographic and lifestyle factors as well as self-reported chronic conditions, was obtained by trained interviewers. MM was defined as “coexistence of two or more chronic conditions in the same person”. Descriptive analysis and logistic regression were performed to compare the prevalence of MM according to different factors. Results: Over a third of the participants (36.6%) had ≥2 chronic conditions and 15.7% had ≥3 chronic conditions. Hypertension, diabetes, musculoskeletal conditions, fatty liver, and heart diseases were common chronic conditions. In a fully adjusted logistic regression model, older age (ORadj=1.92, 95% CI: 1.48-2.48), being female (ORadj=1.49, 95%CI: 1.14-1.94), living without a spouse (ORadj=1.81, 95%CI: 1.34-2.44), and inadequate consumption of fruit and vegetables (ORadj=1.33, 95%CI: 1.06-1.67) were associated with the higher prevalence of MM. Conclusion: This study found that the prevalence of MM is relatively high among older Kurdish adults. Sociodemographic differences in the prevalence of MM might be of interest to the health care system, and the prevalence of common chronic conditions in this study may highlight the need for lifestyle modifications in this community.
Anticholinergics and Benzodiazepines on Cognitive Impairment among Elderly with Alzheimer’s Disease: a One year Follow-Up Study
Authors: Jenraumjit Rewadee , Chinwong Surarong , Chinwong Dujrudee , Kanjanarach Tipaporn , Kshetradat Thanat , Wongpakaran Tinakon , Wongpakaran Nahathai
Published: December 2019

Objective
Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer’s disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months.

Results
A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, Benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs ( t (169), -2.52, p = .020) but not with the groups using BZD ( t (162), 0.84, p = .440). Evidence showed that older adults with Alzheimer’s disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy.
Weight Development Between Age 5 And 10 Years And Its Associations With Dietary Patterns At Age 5 In The ABCD Cohort
Authors: Rashid Viyan , Streppel Martinette T , Engberink Marielle F. , Weijs Peter J.M. , Nicolaou Mary , Verhoeff Arnoud P.
Published: December 2019

Background: Social inequalities in bodyweight start early in life and track into adulthood. Dietary patterns are an important determinant of weight development in children, towards both overweight and underweight. Therefore, we aimed to examine weight development between age 5 and 10 years by ethnicity, SES and thereafter by BMI category at age 5, to explore its association with dietary patterns at age 5.Methods: Participants were 1 765 children from the Amsterdam Born Children and their Development (ABCD) cohort that had valid data on BMI at age 5 and 10 and diet at age 5. Linear mixed model analysis was used to examine weight development between age 5 and 10 years and to assess if four previously identified dietary patterns at age 5 (snacking, full-fat, meat and healthy) were associated with weight development. Analyses were adjusted for relevant confounders, stratified by ethnicity and SES and thereafter stratified per BMI category at age 5.Results: Overall, weight decreased in Dutch and high SES children and increased in non-Dutch and low/middle SES children. Across the range of bodyweight categories at age 5, we observed a conversion to normal weight, which was stronger in Dutch and high SES children but less pronounced in non-Dutch and low/middle SES children. Overall, the observed associations between weight development and dietary patterns were mixed with some unexpected findings: a healthy dietary pattern was positively associated with weight development in most groups, regardless of ethnicity and SES (e.g. Dutch B 0.084, 95% CI 0.038;0.130 and high SES B 0.096, 95% CI 0.047;0.143) whereas the full-fat pattern was negatively associated with weight development (e.g. Dutch B -0.069, 95% CI -0.114;-0.024 and high SES B -0.072, 95% CI -0.119;-0.026). Conclusions: We observed differential weight development per ethnic and SES group. Our results indicate that each ethnic and SES group follows its own path of weight development. Associations between dietary patterns and weight development showed some unexpected findings; follow-up research is needed to understand the association between dietary patterns and weight development. Keywords: BMI, body mass index, thinness, normal weight, overweight, obesity, socio-economic position, ethnicity, children, young children.
Diabetics’ self-care practice and its determinants among Adult diabetic patients in Ethiopia: A systematic review and meta-analysis.Diabetics’ self-care practice and its determinants among Adult diabetic patients in Ethiopia: A systematic review and meta-analysis
Authors: Yehualashet Fikadu Ambaw , Takele Wuber Worku , Tegegne Eleni Tesfaye , Ayele Amare Demsie
Published: December 2019

Background Appropriate diabetic self-care is indispensable to prevent and limit diabetic associated short and long term complications including death. Despite the well-recorded devastating complications of diabetes mellitus, a pooled percentage of diabetic patients applying self-care and its determinants at the national level have remained unknown. Therefore, this comprehensive systematic review and meta-analysis is aimed at determining the pooled national percentage of diabetic self-care practice and its determinants among adult diabetic patients in Ethiopian. Methods: Different electronic databases including PubMed/Medline and search engines such as Google scholar were used to retrieve published studies. The Joanna Briggs Institute quality appraisal checklists were used to appraise the quality of studies. Data were extracted using excel spreadsheets and analyses were done by STATA 14. Heterogeneity among studies was diagnosed using the I2 test. The DerSimonian and Laird random-effects model was employed for substantial heterogeneity (I2>50%). The pooled estimate of diabetic self-care and odds ratio was reported based on the 95% CI. Results: A total of 3861 studies were identified, of which only 19 studies have reached the final qualitative synthesis and quantitative analysis. Well over half of the Ethiopian diabetic patients have good self-care 54.04% (47.07-61.01, I2 =97.3, P<0.001). Subgroup analysis showed that the highest pooled estimate was in Southern Nations Nationalities and Peoples 81.96(71.85-92.04), I2=89.1, P<0.002) while the lowest was from the Hareri region 44.53(32.16-56.89) I2=94%%, P<0.001). Being knowledgeable about diabetes mellitus 2.69 (1.62, 4.46; I2 =99%, P<0.001), having good social support 2.25(1.49-3.39; I2=99%, P=0.00), owning private glucometer 3.04(1.64, 5.65; I2=97.4, P<0.001), and being urban residents 3.26(2.24, 4.74; I2=96.3%, P<0.001) have promoted diabetic victims to apply self-care practice. Conclusions: Despite the life-threatening complications of diabetes mellitus, the percentage of patients applying self-care has remained low in Ethiopia, depicting the high proportion of diabetic patients are prone to develop long and short term complications of diabetes mellitus. Therefore, improving the client’s awareness about the disease and counseling clients about the significance of social support are believed to be possible strategies to improve self-care practice and policymakers are strongly recommended to combat complications to attain sustainable development goal 3.4 aims to reduce premature death.
Unmet need for modern contraceptive method and associated factors among married women in mekelle city, Tigray, Ethiopia: Community based cross sectional study
Authors: Hailu Desta , Tekeste Senait , Siyoum Desta
Published: December 2019

Background: Contraceptive use has increased markedly in the recent years in most developing countries, due to desire for smaller families; however, millions of women still want to delay or avoid pregnancy but are not using contraception to limit or to space their birth.Thus, the objective of this study is to assess unmet need for family planning among married women in Mekelle city, Tigray. Methods: Community based cross-sectional study was conducted among married reproductive age women. Data were collected from October, 15 up to Novmber, 15/ 2018. A total of 426 study participants were interviewed using a systematic random sampling technique. Structured and interviewer administered questionnaire was used to collect the data and were analyzed using SPSS version 22. Bivariate and multivariable logistic regression models were used to assess the predictors of the outcome variable. P-value of less than 0.05 was considered to test statistical significance. Results: The overall unmet need for modern contraception among the currently married women of reproductive age women was 19.7% (95% CI: 16.2%-23.7%) and of which 13.3% was unmet need for spacing and 6.4% was unmet need for limiting.Age of mother (25-34 years: AOR =2.79, 95%CI =1.03-7.60), occupational status of mother (AOR =2.72, 95%CI =1.72-4.02), number of living children (AOR =2.31 95%CI =1.09-4.84) and knowledge of mother about modern contraceptive methods (AOR =3.38, 95%CI=1.82-9.92) were independent predicators for unmet need for modern contraception. Conclusion: The prevalence of unmet need for contraception is low. Age of mother, occupational status of mother, number of children and knowledge of mother about modern contraceptive methods were the independent predicators for unmet need of modern contraception. Strong effort should be made by health care workers to reduce unmet need and policy makers should use different approaches to educate women about modern contraception and increase its utilization for spacing and limiting.