bluuebunny/crossref_metadata_2025 huggingface dataset:
The European experience of "Neurology journal club" at the Department of Neurology and Reflexology, Shupyk National Medical Academy of Postgraduate Education
Authors: Svyrydova N. , Podhornaya K. , Kucheeva I. , Zabolotnaya V. , Borshchak L. , Potyevskaya A. , Nechyporuk A. , Slavnykova V.
Published: February 2019

World Medical evidence shows the positive experience of the neurological journal clubs and the quarterly report as an article on the Review provided material for practicing neurologists, to subsequently provided to effectively use the material in their clinics. Topics presented by Special Interest Group in the analysis of topical articles and reviews neurological areas participating in the program of professional education in Europe, to help in the education and practical work towards practicing neurologist.
Practical lesson «Secondary acute encephalopolyradiculoneuropathy»
Authors: Sereda V. , Svyrydova N. , Parnikoza T. , Khanenko N. , Cherednichenko T. , Mykytei O. , Ingula N. , Svystun V. , Ruda N. , Artemenko A. , Bartosh K. , Lozna I. , Gapon A.
Published: February 2019

Acute encephalopolyradiculoneuropathy - syndromic disease, which is mostly representing secondary damage of the nervous system. Among patients with verified herpetic neuroinfection, encephalopolyradiculoneuropathy type composes 20% cases. In 30-60% of cases infection, hypothermia, toxic lesions, vaccination, surgery precede this disease. Symptoms increase within few days till 1 month. In 25% of cases respiratory and bulbar muscles, cranial nerves are affected. The clinical case of secondary acute encephalopolyradiculoneuropathy with bulbar disorders and mild pain syndrome has a mixed genesis - infectious and allergic, arouses interest because of increasing frequency. The attention focused on this group of diseases, namely because of the difficulties in differential diagnosis and effective treatment.
Experience of application of acupuncture in pain syndrome as a means of increasing the «pain threshold»
Authors: Svyrydova N.
Published: February 2019

The paper shows ways to optimize the training of doctors in the field of Reflexotherapy. Used problem methodology of training, provided experience in organizing practical classes, clinical examinations of patients. Іmportance in the process of training specialists at the Department of Neurology and Reflexology is given to practical classes, where students must realize in a real clinical situation, at the bed of the patient, they mastered theoretical ideas about the mechanisms of therapeutic action of reflexotherapy in certain diseases and conditions, indications and contraindications to the conduct of procedures Reflexotherapy, the method of selecting patients for reflexology and recreating the acquired skills of acupuncture diagnosis and procedures. Reflexology A significant role in the preparation of future reflexology doctors is also given to seminars, which have the role of a kind of chain between theoretical knowledge and their practical implementation in clinical work: it requires a logical doctor’s actions and skills in making specific decisions. Practical’s are carried out for various types of seminars, but the most popular are the colloquium workshop and clinical-workshop. Situation tasks are made on the basis of the «Bank» of clinical treatments according to different nosology’s. The presented clinical cases based on data analysis of patients who were under the supervision of teachers of the Department of Neurology and Reflexology and were used in the preparation of seminars-clinical treatments, dealing with the treatment of patients with pain syndromes using reflexotherapy. Presented clinical cases of effective use of acupuncture treatment in patients with pain syndromes due to reduction of «pain threshold».
Features of electrical brain activity in patients with multiple sclerosis, taking into account the comorbidity
Authors: Chupryna G. , Svyrydova N. , Kozlov V.
Published: February 2019

The results of the study of brain electrical activity in patients with multiple sclerosis (MS) in the aspect of comorbidity are shown in the work. EEG-study was conducted by 30 patients with MS in dynamics and 15 persons in the control group. The revealed changes in the EEG in patients with MS indicate the dysfunction of the mid-stem brain structures. In the general sample, 46.7% of patients had signs of a decrease in the ascending activating effects on the cortex from the side of the reticular formation of the brainstem. Signs of lowering the threshold of convulsive readiness and irrigation in the form of the alpha-wave activity of the alpha and beta-1 frequency bands, as well as acutewave-slow wave complexes and outbreaks of multiple (beta-1 and beta-2) -waves were detected. In 90% of patients in the general sample, there was a decrease in resistance to functional loads. It was established that in MS patients with comorbidity there is a significant (p <0.001) increase in the spectral power of brain electrical activity in the temporal leads of the right hemisphere in the ranges of theta and beta 1 frequencies and increasing the power of beta-2 activity in the occipital, parietal and temporal leads of both Hemispheres. In terms of the maximum absolute power in the beta-2 frequency range, the differences between the groups were for the large number of leadings of both hemispheres, which may reflect the specific features of the CNS activity, and be associated with the course of MS against the background of comorbidity, in particular pain syndromes.
Vegetative-vascular dystonia: etiopathogenesis, clinical picture, diagnosis, treatment (clinical lecture)
Authors: Cherednichenko T. , Sereda V. , Svyrydova N. , Parnikoza T. , Chuprina G. , Khanenko N. , Sulik R. , Mykytei O. , Svystun V.
Published: February 2019

This article discusses the clinical lecture on the problem of terminology, etiology and pathogenesis, diagnosis and treatment of vegetative dystonia. Also featuring a modern classification of autonomic disorders, are the criteria for the differential diagnosis of autonomic crises. Given the urgency of the problem in the structure of autonomic disorders of neurological diseases, the focus of the lecture material placed on pathogenetically justified therapeutic measures. The manifestations of dysregulation manifest as dysfunction of the endocrine, simpatoadrenalovoj and cholinergic systems, disorders of water and salt, and acid-base status, oxygen supply of physical activity, the oxygen reduction in the tissues, which leads to activation of metabolic disorders, microcirculation with the development of pathological processes in the myocardium and the emergence of hypertension. Therefore, expansion of clinical and diagnostic indicators in preparation for the lecture topics will contribute to a more effective professional development specialists.
New features combined neuroprotective therapy in patients with chronic stroke against the background of cardiovascular pathology
Authors: Svyrydova N. , Zhhilova N.
Published: February 2019

In this article discusses the study of the drug Olatropil on the dynamics of the functional state of the brain in patients with chronic stroke against the background of cardiovascular disease. It has been proved the impact of dysfunction autonomic nervous system on the emergence of cognitive and psycho-emotional disorders that can serve as an early diagnostic criterion to identify these disorders Application of of combined nootropic medicinal drugs Olatropil in a complex treatment has a reliable positive impact on the dynamics of the functional state of the brain, gives true opportunity to decline and progression in patients with worsening opportunities switch to different activities, reducing the need for activity and communicating with increasing sensitivity to setbacks and high self-control. It has been shown that using of Olatropil in treatment of these patients improves treatment efficacy as a whole by restoring 1) vegetative lability, 2) improving cognitive function, and 3) reducing anxiety.
Lecture of the cycle of specialization in reflexology "Using reflexotherapy for craniocerebral trauma"
Authors: Parnikoza T. , Trufanov Y. , Svyrydova N. , Chupryna G.
Published: February 2019

Improvement of the course on the topic "Reflexotherapy Specialization" of the lecture material on the topic "Use of reflexotherapy for craniocerebral traumas" would help to solve the problem of reducing the pharmacological burden on patients and, consequently, minimizing possible complications and side effects of pharmacotherapy. The theory and practice of reflexology is accelerated by a physician-clinician, which contributes to the problematic teaching methodology, which is based on the formation of problems in clinical situations, which greatly increases the activity of the students, targets them for practical activity, improves the mastering of the theoretical program. During lectures on the specialty cycle of reflexology, such problem situations are widely used, when the teacher creates a certain contradiction of real facts on the basis of generalized medical knowledge, creates a problematic situation and solves it together with the listeners.
Safety of NSAID use among patients with cardiovascular diseases
Authors: Svyrydova N.
Published: February 2019

Today, in medical practice, the number of patients who for a long time with the development of acute or chronic pain syndrome are forced to use non-steroidal anti-inflammatory drugs (NSAIDs) is steadily growing. At present, the problem of the relative cardiovascular safety of NSAID use is topical, which causes serious concern in the treatment of patients with severe vascular comorbidity. The safe use of NSAIDs, especially among elderly patients who may be at high risk for CVD or adverse gastrointestinal (GI) complications, is a constant problem for the doctor. Although the results of PRECISION provide an overview of the overall safety of these NSAIDs, the conclusions about the relative safety of celecoxib, naproxen and ibuprofen are complex and represent remaining gaps in knowledge. In a low-risk population in which the majority of patients received treatment for risk reduction, the data indicate that short-term CRs associated with all three drugs are really low and similar. There remains an open question about the effect of the duration of treatment and the dose of NSAIDs on the risk of cardiovascular disease. The meta-analysis did not reveal an increased risk of NSAIDs when used for less than 30 days or less than in full doses. It is recommended to evaluate the use of NSAIDs in patients based on individual risk factors to optimize the balance between anti-inflammatory and potential adverse events.
Painful Syndromes: Mechanisms of Nociception and Antinociception
Authors: Svyrydova N. , Chuprina G. , Parnikoza T. , Sereda V. , Khanenko N. , Cherednichenko T. , Svystun V. , Yelizarova О.
Published: February 2019

Traditionally, two main concepts are considered in the views on morphophysiological bases of pain. The first concept suggests that the skin has pain receptors, from which begin the specific afferent pathways to the brain, where there are special centers for the treatment of pain information. Another concept put forward by the Goldscheider is a non-specific pain theory, or a theory of intensity, a «pattern» according to which any sensory stimulus that reaches a certain intensity can cause pain. That is, specific pain structures do not exist, and pain is the result of a combination of thermal, mechanical and other sensory stimuli.
Pompe disease
Authors: Svyrydova N. , Yelizarova О. , Svystun N.
Published: February 2019

. Pompe disease is a rare, progressive disease, the basis of which is the pathogenesis of excessive accumulation of glycogen by lysosomes due to mutation of the GAA gene and loss of activity of the enzyme acidic α-glucosidase. Preferred accumulation of glycogen is noted in cross-linked muscles, but can vary in degrees in other organs and tissues, including cardiac muscle, liver, nervous system. The type of inheritance is autosomal recessive. In clinical practice, the detection of characteristic symptoms allows you to timely suspect Pompe disease. Sufficient awareness and alertness of the doctor about Pompe's disease, with a combination of characteristic symptoms, facilitates diagnosis. RT in T1 mode makes it easy to assess muscle tropism and to identify specific areas of fibrous-fat degeneration, which is characteristic of muscular dystrophy. The study of muscular biopsy in Pompe disease reveals a vacuated myopathy of lysosomal nature in determining the activity of acid phosphatase, in a histo-enzymatic study, as well as glycogen accumulation. The basis of the biochemical diagnosis of Pompe disease is the study of the activity of the enzyme GAA with the help of natural or synthetic substrates in the acidic medium. Modern molecular biology techniques can predict the severity of the disease, which correlates with the residual activity of the enzyme. Life-long enzyme replacement therapy for recombinant human acid α-glucosidase in patients with a confirmed diagnosis of Pompe disease is recommended. Enzyme replacement therapy helps preserve life for patients with Pompe disease, improves its quality and slows the progression of the disease. The early start of therapy is very important, because it allows you to achieve the best clinical results. The use of enzyme replacement therapy in childhood disease has been shown to reduce the risk of death by 99%, and the risk of death or need for invasive ventilation is 92%. In the presence of a confirmed diagnosis of Pompe disease, regardless of the age of the patient, pathogenetic therapy with alglucosidase alfa should be initiated immediately.
Acts Aspect to the result of a cerebral hemorrhagic supratentorial session on the basics of analisys in the tentorial wedge
Authors: Bobrova V. , Shevchenko L. , Khokhlov Y.
Published: February 2019

Cerebral transtentorial herniation determinates the course of progressive focal supratentorial impairments and acute hemorrhagic hemispheric stroke. Clinical and pathomorphological comparisons were done in patients with acute hemorrhagic hemispheric stroke. The following predictors of hemorrhagic hemispheric stroke lethal outcome were verified: 1) acute onset of coma in association with oculomotor dysfunctions; 2) focal hemiplegia in association with peduncular hemiplegia and paratonic rigiditydue due to compression of ipsilateral peduncle; 3) quick addition of vital disorders due to hemorrhagies into tectorium and it’s necrobiosis; 4) lethal outcome caused by herniation into occipital foramen due to necrobiosis of neurons in caudal part of brain stem tectorium.
Rare causes of stroke in young people
Authors: Borzenkov S. , Svyrydova N. , Borzenkova L.
Published: February 2019

One of the reasons that can lead to a stroke in young people is Fabry’s disease. This is one of the rare, genetically determined diseases of the X – linked type of inheritance, belonging to the group of lysosomal diseases of accumulation (synonyms: diffuse universal angiokeratoma, hereditary dystonic lipidosis, deficiency of alpha galactosidase A). The genetics of Fabry disease is due to mutations in the GLA gene characterized by a significant decrease in the activity or absence of the enzyme α-galactosidase A. These deviations result in the accumulation of glycosphingolipids, namely, ceramide accumulated in the cytoplasm or lysosomes of cells of various organs and tissues, disrupting their function, causing ischemia and tissue fibrosis. A specific laboratory diagnosis is the determination of the activity of alpha-galactosidase A. In Fabry’s disease, the activity of alpha-galactosidase A in men in men is always reduced, and in women, the activity of GLA may be near the lower limit of norm, or slightly lower, or normal. In Fabry disease symptomatic therapy and enzyme replacement therapy are used to reduce the severity and prevent the symptoms of Fabry disease. Antiplatelet therapy should be the basis of treatment. With timely access to enzyme replacement therapy, the prognosis is favorable.
Emergency conditions: pathogenesis and treatment of fever in children
Authors: Bobrova V. , Nikiforov S.
Published: February 2019

The paper presents the concepts of temperature homeostasis, the leading role of the hypothalamus in the mechanism of thermoregulation, etiology, the pathogenesis of fever and its pharmacotherapy in children.
The role of B vitamins in the treatment of back pain
Authors: Svyrydova N.
Published: February 2019

In 2018, an analysis of epidemiological studies was conducted that provided information on the prevalence of back pain and identified individual, psychosocial and occupational risk factors for the onset of this pathology. It is important that when choosing the tactics of treatment, it is necessary to take into account the risk of complications in the presence of multimorbid pathology in patients with acute or chronic pain syndrome. Increasing the effectiveness and safety of therapy based on the use of nonsteroidal anti-inflammatory drugs, the risk of which can be minimized, is associated with the inclusion of B vitamins. The results of various clinical studies on the use of the B complex of vitamins showed a significant decrease in the severity of the pain syndrome and a significant improvement in motor functions, regression of sensitive disorders.
Neurophysiological bases of application of methods of reflexotherapy in treatment of multiple screllosis (Clinical lecture)
Authors: Chuprina G. , Svyrydova N. , Parnikoza T. , Svystun V. , Shcherbaty A.
Published: February 2019

The main neurophysiological mechanisms of the sanogenetic action of acupuncture with multiple sclerosis are considered in the article. Clinical results of the use of reflexotherapy in a complex of therapeutic measures in this disease are shown according to the analysis of published sources and the results of their own observations. Neurological syndromes of multiple sclerosis and comorbid diseases are presented, in which reflexotherapy methods provide the greatest therapeutic effect.
Lecture of the specialization cycle on reflexotherapy "Headache: Clinic, Diagnosis and Treatment"
Authors: Svyrydova N. , Chuprina G. , Parnikoza T. , Sereda V. , Cherednichenko T. , Svystun V. , Yelizarova О.
Published: February 2019

In order to find out the mechanisms of headache, the issue of innervations of craniocervical site structures is important, as irritation of any of them may cause headache. The parenchyma of the brain and the skull bones have only a small amount of nerve fibers that carry nociceptive information, whereas in the walls of the arteries, vascular and solid brain sines and sinuses, there is the largest number of nociceptors. Nerves of the orophacial region transmit nociceptive information to the trunk of the brain (through thistles, cranial and stony nodes), where through the trigeminal nuclear complex and the dorsal lemniscus system the transmission of pain information to the back of the thalamus is carried out (in addition, it is transmitted by the spinothalamic pathway and thalamic projections from caudal abider of the trigeminal nuclear complex). Thus, the important role of the trigeminal nerve system in the transmission of information to the central nervous system has been proved, the fact of innervation of the brain vessels of the trigeminal nerves is confirmed, which confirms the activity of the trimeric and vascular system, which is the main system that perceives pain impulse and leads to changes in the tone of the vascular wall of the head . This mechanism has the maximum value in the case of migraines headache, which made it possible to put forward the trigeminal vascular theory of migraine pathogenesis. Thalamic pain is a consequence of lesions of the lateral thalamus, including its posterior lateral ventral nucleus, and on the opposite side of the lesion there is a constant burning pain that is unclearly localized, amplified by attacks with emotional stress, sharp acoustic, visual, olfactory stimuli. The study of pathogenetic and diagnostic criteria of pain is an important component in the differential diagnosis of nociception, since this component is an important component in the practice and treatment of reflexology therapists in the selection of diagnostic criteria and therapeutic tactics / Considering the classification, clinical subtype, special characteristics of the pathogenesis of pain development has an important diagnostic importance for preventive measures in the practice of doctors.
Ischemic stroke and myocardial infarction: promising therapeutic goals for protecting the brain and heart
Authors: Svyrydova N.
Published: February 2019

During the last decade of medical practice, the issue of integrated treatment of ischemic heart and brain damage is actively discussed, therefore the attention of scientists is increasingly of interest in the creation of potentially new models of treatment in the acute period of illness. Many researchers today actively pursue various pharmacological modulations with a complex of pathogenetically validated effects of various isoforms that are involved in the development of stroke, myocardial infarction, diabetes mellitus, atherosclerosis, Alzheimer's disease, Parkinson's disease, tumor growth, inflammatory diseases, heart failure and hypertrophy of the myocardium. In recent years, progress in treatment tactics has been achieved in studies that affect oxidative stress, which leads to irreversible effects of damage to the gray and white matter of the brain, which entails swelling and massive cell death, and therefore justifies the use of antioxidant therapy. The concept of the use of antioxidants in the early stages of the disease demonstrates promising direction and requires further study in various pathological conditions, since the potential for treatment effectiveness is quite high. The use of antioxidant therapy aimed at preventing or reducing oxidative stress has become widely used in the field of prevention and treatment of acute and chronic conditions, where the use of drugs with a pliotropic effect is of strategic importance. To study the evaluation of the neuroprotective effect of ethyl methylhydroxypyridine succinate recently, cytological studies of the effect of glutamate stress on cerebellum cells have been performed and it has been shown that the drug affects the increase in neuronal survival (p <0.05), where the focus is on pharmacotherapy of the combination of neuroprotective treatment of cerebrovascular pathology.
Lecture of the cycle of specialization in reflexology "Applying the theory of IN and YN in traditional Chinese medicine"
Authors: Chuprina G. , Trufanov E. , Svyrydova N. , Bondarenko A. , Svystun V. , Shcherbaty A.
Published: February 2019

In the teaching of the lecture course "Applying the theory of IN and YN in traditional Kite medicine" in the cycle of specialization with "reflectotherapy", an especially important direction is the analysis of the relationship between several theories of H1 and HH. The teachings of IN and YN are used in all aspects of traditional Chinese medicine. It is the basis of anatomy, physiology and pathology of the human body, and it is based on clinical acupuncture diagnosis and acupuncture treatment. INN-YN theory and anatomical peculiarities of the human body: in the explanation of the structure of the human body based on the INN-YN theory, the assertion that the human body is considered as a whole is used.
Features of neuroimaging data in patients with chronic cerebral ischemia on the background of angina pectoris
Authors: Inhula N.
Published: February 2019

In the article the features of bioelectric activity and magnetic resonance imaging of the brain in patients with chronic cerebral ischemia (CCI) are exposed on the background of stable angina of the voltage ІІ and ІІІ ФК. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.2.6 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted complex neuroimaging examination of patients with ССI on the background of stable angina was collected and provided. Based on the data obtained using neuroimaging techniques, it has been established that in patients with CCI, against the background of stable angina, the course of the disease is associated with the risk of development of the acute cerebrovascular accident.
Metabolic Therapy in hypertensive encephalopathy: emphasis on comorbidity of pathology
Authors: Svyrydova N.
Published: February 2019

The development of primary and repeated disorders of cerebral circulation, vascular dementia, transient ischemic attacks, which are a consequence of the development of acute pathology in patients with hypertensive encephalopathy, lead to a state of persistent disability and disability. Today, the emphasis of treatment is placed on the important role of oxygen deficiency, which leads to the restriction of aerobic energy production due to disturbances in the energy-synthesizing function of the mitochondrial respiratory chain, depletion of endogenous antioxidant stores and activation of lipid peroxidation of cell membranes, leading to death of brain cells. By 2018, a large evidence base for the effectiveness of the use of metabolic therapy in neurology, which takes into account an important factor of the impact of comorbidity of the pathology. The effectiveness of antioxidant therapy in acute and chronic cerebrovascular diseases is confirmed by the fact that the antioxidant improves energy metabolism in the cell, and as a metabolite of the tricarboxylic acid cycle (succinate, which provides pronounced antioxidant and antihypoxic properties) has a positive effect on the main links of pathogenesis of diseases associated with processes freely Radical oxidation. It is proved that the preparation of Mexicor reduces the manifestation of oxidative stress, inhibits free radical peroxide oxidation of lipids, improves cellular energy metabolism, activates the energy-synthesizing functions of mitochondria, enhances compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle. The drug Mexocor has a wide spectrum of pharmacological action, which allows it to be used successfully in acute and chronic cerebrovascular diseases, accompanied by vascular comorbidity.
Investigation of SWI - basal nucleus intensity and fractional anisotropy of cerebral pathways in patients with chronic cerebral ischemia
Authors: Petrenko M. , Grabovetskii S.
Published: February 2019

Mild parkinsonian signs (MPS) and cognitive decline are common symptoms of small vessel disease (SVD), and are associated with reduced life quality and duration. There is a probable relationship between the neuroimaging features and SVD symptoms. Objective of this study was to identify whether there is an association between SWI basal nucleus hypointensity, fractional anisotropy and SVD symptoms such as cognitive decline and MPS.
DETERMINAN SOSIAL, BUDAYA DAN KESEHATAN SERTA FAKTOR RISIKO KEHAMILAN REMAJA DI NEGARA MISKIN DAN BERKEMBANG
Authors: Legawati Legawati , Nugraheni Sri Achadi
Published: February 2019

Latar Belakang : Kehamilan remaja adalah salah satu masalah penting di abad 21. Ada lebih dari 14 juta remaja yang sudah melahirkan setiap tahunnya. Ada 12,8 juta kejadiannya di Negara berkembang. Tingkat tertinggi di Afrika. Ada beberapa Negara tertinggi lainnya meliputi India, Bangladesh, Amerika Latin dan Caribbean. Angka rata-rata melahirkan per 1000 pada umur antara 15-19 tahun adalah 115 di Aprika, 75 di Amerika latin dan Karibia dan 39 di Asia.Tujuan: Review ini bertujuan untuk melakukan identifikasi determinan kesehatan dan faktor risiko kehamilan remajaMetode: Menggunakan framewotk dari Arskey and O’malley. Mesin pencari yang digunakan adalah PubMed, Medline, Science Direct, EBSCO, Cambridge Core, Proquest, Emerald insight, Scopus, SpingerHasil : Mesin pencari online mendapatkan sejumlah 7257 yang relevan untuk dilakukan citasi yang 367  memenuhi syarat setelah dilakukan review judul dan abstrak. Setelah dilakukan skrining melalui review full text artikel didapatkan sejumlah 20 artikel yang memenuhi kriteria inklusi. Kehamilan remaja dipengaruhi oleh banyak faktor termasuk kemiskinan, sosial ekonomi dan budaya, norma serta keyakinan, pendidikan yang rendah (remaja dan orangtua), drop out atau dikeluarkan dari sekolah sehingga mempengaruhi kesempatan untuk mngikuti pendidikan berkelanjutan, kepercayaan diri remaja, kedekatan dengan keluarga khususnya ibu, kehadiran ayah dan struktur keluarga serta penerimaan keluarga terhadap prilaku berisiko remajaKesimpulan: Mengingat kondisi kehamilan remaja yang masih tinggi dan banyak memberikan dampak negative bagi kesehatan ibu dan bayi, maka diperlukan sebuah tim dalam membentuk sistem kesehatan yang berorientasi pada kesehatan remaja khususnya untuk kehamilan remaja, yang seharusnya dilakukan pencegahan sebelumnya. Apabila, menemukan ibu hamil remaja, maka diharapkan kondisi kesehatan ibu dan bayinya lebih optimal
HUBUNGAN ANTARA TINGKAT STRES DENGAN GANGGUAN SIKLUS MENSTRUASI PADA MAHASISWA
Authors: Triwahyuningsih Ria Yulianti
Published: February 2019

LATAR BELAKANG : Menurut penelitian yang dilakukan di sejumlah negara, termasuk negara-negara berkembang lainnya, dikatakan bahwa gangguan menstruasi merupakan masalah yang cukup banyak dihadapi oleh wanita dengan pravalensi 75% pada remaja akhir (Sianipar et al., 2009). Salah satu penyebab gangguan menstruasi pada wanita adalah faktor stres. Stres dalam mempengaruhi siklus menstruasi yaitu melibatkan sistem hormonal sebagai sistem yang berperan besar pada reproduksi wanita.TUJUAN : Diketahui hubungan antara tingkat stres dengan gangguan siklus menstruasi pada Mahasiswa Tingkat I dan II Program Studi D III Kebidanan di STIkes Muhammadiyah Cirebon Tahun 2017.METODE : Penelitian ini merupakan penelitian kuantitatif dengan desain deskriptif korelatif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh Mahasiswa Tingkat I dan II Program Studi DIII Kebidanan di STIKes Muhammadiyah Cirebon T.A.2017/2018 yang berjumlah 137 mahasiswi. Pengambilan sampel menggunakan probability simple random sampling dan didapatkan sampel sebanyak 102 orang. Instrumen pengumpulan data menggunakan Kuesioner DASS 42 Termodifikasi dan lembar cheklist tentang siklus menstruasi. Teknik analisis data menggunakan uji statistik chi-square dan uji kontingensi.HASIL : Sebagian besar mahasiswi mengalami stres sangat berat, yaitu 48 orang (47%) dan yang mengalami gangguan siklus menstruasi yaitu 102 orang (100%). Hasil uji statistik Chi Square hitung 9,25075 dan  diperoleh nilai taraf signifikan yaitu 0,1559 (P value > 0,05) dan besar koefisien kontingensi C 0,28.SIMPULAN : Tidak terdapat hubungan yang signifikan antara tingkat stres dengan gangguan siklus menstruasi dengan taraf signifikan 0,1559 dan koefisien kontingensi C 0,28.
ANALISIS PENGETAHUAN DENGAN SIKAP IBU TENTANG IMUNISASI HB0
Authors: Masan Lea
Published: February 2019

Latar Belakang : Penyakit hepatitis dari berbagai tipe merupakan masalah kesehatan terbesar di seluruh dunia. Hepatitis virus memiliki beban penyakit yang besar di dunia, lebih besar dibandingkan dengan penyakit menular utama lainya, seperti HIV, TBC dan Malaria. Rendahnya angka cakupan Imunisasi HB0 yang diberikan kurang dari 24 jam pada bayi itu disebabkan karena sebagian masyarakat tidak atau belum tahu manfaat Imunisasi HB0 sebaiknya diberikan segera setelah lahir.Metode Penelitian : Penelitian ini bersifat kuantitatif dengan pendekatan Cross Sectional. Sampel yang diambil berjumlah 30 orang ibu yang mempunyai bayi usia 0-2 bulan di Klinik Pratama IBI Cabang Kabupaten Sintang Tahun 2018. Teknik pengambilan sampel dengan menggunakan metode Purposive sampling. Instrument yang digunakan dalam penelitian ini menggunakan kuesioner tertutup. Analisis data dalam penelitian ini menggunakan analisis bivariat dengan uji Chi Square. Hasil Penelitian : Hasil penelitian dengan analisis uji Chi Square dengan nilai p value = 0,03 < 0,05, yang artinya Ho ditolak dan Ha diterima. Kesimpulan : Ada hubungan antara pengetahuan dengan sikap ibu tentang imunisasi HB0 di Klinik Pratama IBI Cabang Kabupaten Sintang tahun 2018. Dari 30 orang responden, 20 orang memiliki pengetahuan kurang baik (67%). Sedangkan dari 30 responden, 20 orang menunjukan sikap tidak mendukung dalam pemberian imunisasi HB0 (67%).
DUKUNGAN SUAMI DAN DUKUNGAN PETUGAS KESEHATAN TERHADAP PERILAKU PEMERIKSAAN IVA PADA WANITA USIA SUBUR
Authors: Kurniati Paskalia Tri
Published: February 2019

Deteksi dini kanker leher rahim merupakan terobosan inovatif dalam pembangunan kesehatan untuk mengurangi angka kematian dan kesakitan akibat kanker leher rahim. Data yang diperoleh menunjukkan adanya penurunan di tahun 2016 kunjungan skrining IVA ke Puskesmas Tanjung Puri, walaupun ditahun 2017 meningkat kembali namun ditemukan 2 orang dengan hasil IVA positif. Tujuan penelitian mengetahui hubungan dukungan suami dan dukungan petugas kesehatan dengan pemeriksaan IVA pada wanita usia subur (WUS) di Wilayah Kerja Puskesmas Tanjung Puri Sintang Tahun 2018. Metode penelitian ini jenis penelitian Kuantitatif Non Eksperimental dengan menggunakan pendekatan studi korelasi (cross sectional).  Sampel pada penelitian ini diambil secara accidental sampling pada minggu pertama bulan Desember yang berjumlah 57 wanita usia subur (WUS). Hasil penelitian penulis mendapatkan wanita usia subur terbanyak tidak pernah melakukan pemeriksaan IVA yaitu 34 (59,6%), dukungan suami terbanyak yang buruk yaitu 29 (50,9%) dan dukungan petugas kesehatan yang yaitu 31 (54,4%). Kesimpulannya adalah ada hubungan antara dukungan suami dengan perilaku pemeriksaan IVA, dengan P.value = 0,016 (P <0,05) dan ada hubungan antara dukungan petugas kesehatan dengan perilaku pemeriksaan IVA, dengan P.value = 0,032 (P<0,05). Saran, perlu dilakukan upaya peningkatan sosialisasi dan cara penyampaian informasi yang efektif dan berkesinambungan oleh petugas puskesmas.
Resisting the Intelligence Almost Successfully: Wallace Stevens's ‘Academic’ Style
Authors: Andrews Kimberly Quiogue
Published: February 2019

While the sweeping referentiality of T. S. Eliot or Ezra Pound might seem to form the clearest connection between modernist innovation and academic work, this essay argues that it is in fact Wallace Stevens's erudite irony that most precisely anticipates the current set of relations between innovative poetry and the discipline of literary criticism. Stevens's work can thus be analysed as an intellectual collaboration not with a particular scholar or discipline but with the development of discourses specifically concerned about the value of hermeneutics. In particular, his poetry looks towards academic anxieties about the world in which the humanities now live: one that relentlessly demands educational pragmatism. This anticipation takes the form of a persistent concern regarding the artistic capabilities of abstract cogitation, something he puts into uneasy contact with a more intuitive notion of ‘natural’ positivism. This contact, in turn, manages to resist both the remnants of Romanticism and fin-de-siècle discussions about educational rationalization via a similar form of reflexive critical thinking. By foregrounding the tension between the ‘real’ and thinking about reality, Stevens turns his readers into co-workers, as both struggle to carve out a place for the difficult, impractical effort of interrogating what we can know about the world.
Seeing is believing? Public exposure to Gaelic and language attitudes
Authors: O'Hanlon Fiona , Paterson Lindsay
Published: February 2019

In language planning for minority languages, policy often aims to positively influence attitudes towards the language by increasing its salience in key areas of public life such as broadcasting and signage. This is true for Gaelic in Scotland, where recent national initiatives have included the establishing of a Gaelic language television channel in 2008, and the launch, in the same year, of a bilingual brand identity for ScotRail (Rèile na h-Alba), resulting in Gaelic-English signage at railway stations across Scotland. However, there is a lack of empirical evidence on the effects of such an increase in national visibility of Gaelic on public attitudes towards the language. The present paper explores this using a national survey of public attitudes conducted in Scotland in 2012. Exposure to Gaelic broadcasting was found to be positively associated with attitudes towards the status of the Gaelic language (as a language spoken in Scotland, and as an important element of cultural heritage), and with attitudes towards the greater use of Gaelic (in public services and in the future). However, exposure to Gaelic signage was often negatively associated with such broader attitudes to the language and culture. The implications of the results for Gaelic language planning, and for future academic studies of language attitudes in Scotland, are explored.

The authors acknowledge the support of the funders of the research – the ESRC (Grant number ES/J003352/1), the Scottish Government, Bòrd na Gàidhlig, and Soillse.
NOTCH3 Overexpression and Posttranscriptional Regulation by miR-150 Were Associated With EGFR‐TKI Resistance in Lung Adenocarcinoma
Authors: Zhang Youwei , Chen Bi , Wang Yongsheng , Zhao Qi , Wu Weijun , Zhang Peiying , Miao Liyun , Sun Sanyuan
Published: February 2019

Acquired resistance remains a key challenge in epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) therapy in lung adenocarcinoma (LUAD). Recent studies have shown that Notch signaling is associated with drug resistance. However, its role and possible mechanisms
in EGFR-TKI resistance are not yet clear. In our study, we found that among four members of NOTCH1‐4, only NOTCH3 was upregulated in LUAD tissues and TKI-resistant cell line (HCC827GR6). Knockdown of NOTCH3 by siRNA significantly inhibited proliferative ability, and decreased colony
and sphere formation in HCC827GR6 cells. Then miR-150 was identified as a posttranscriptional regulator of NOTCH3. Its expression was downregulated in LUAD tissues and negatively correlated with NOTCH3 mRNA. The cell proliferation and IC50 of gefitinib were decreased in HCC827GR6
cells transfected with miR-150 mimic, but was reversed when cotransfected with NOTCH3 overexpressed vector. Moreover, we also enrolled 20 patients with advanced LUAD who have taken TKIs as first-line therapy in this study. We found that collagen 1A1 (COL1A1) expression was increased significantly
in LUAD tissues both at mRNA and protein levels, and positively correlated with NOTCH3 expression verified in our data and TCGA data. Univariate survival analysis showed that patients with high protein expression of NOTCH3 or COL1A1 were associated with shorter overall survival (OS). Taken
together, these results suggest that miR-150/NOTCH3/COL1A1 axis contributed to EGFR‐TKI resistance in LUAD, which provide a potential therapeutic target for LUAD treatment.
Advanced scanning probe lithography using anatase-to-rutile transition to create localized TiO2 nanorods
Authors: Kalb Julian , Knittel Vanessa , Schmidt-Mende Lukas
Published: February 2019

In this article, we demonstrate the position-controlled hydrothermal growth of rutile TiO2 nanorods using a new scanning probe lithography method in which a silicon tip, commonly used for atomic force microscopy, was pulled across an anatase TiO2 film. This process scratches the film causing tiny anatase TiO2 nanoparticles to form on the surface. According to previous reports, these anatase particles convert into rutile nanocrystals and provide the growth of rutile TiO2 nanorods in well-defined areas. Due to the small tip radius, the resolution of this method is excellent and the method is quite inexpensive compared to electron-beam lithography and similar methods providing a position-controlled growth of semiconducting TiO2 nanostructures.
Antijüdische Politik und deren Bewältigung. Das Wirken der Sozialversicherungsabteilung des Reichsarbeitsministeriums im „Dritten Reich“
Authors: Klimo Alexander
Published: February 2019

Zusammenfassung
Der Beitrag beleuchtet die Rolle der Rentenversicherungspolitik des Reichsarbeitsministeriums im „Dritten Reich“. Auf der einen Seite stellt er dar, wie die Rentenversicherung herangezogen worden ist, um zusätzliche Arbeitskräfte für den Arbeitseinsatz zu gewinnen. Dabei wurde die Rentenversicherung durch die Gesetzgebung des Reichsarbeitsministeriums komplett auf die Anforderungen des nationalsozialistischen Arbeitseinsatzes ausgerichtet. Auf der anderen Seite beleuchtet er die Diskriminierung von jüdischen Versicherten und Rentnern. Die zuständigen Beamten des Reichsarbeitsministeriums und der Rentenversicherungsträger besaßen umfangreiche Freiräume, um die Ziele des Regimes zu verfolgen und zu unterstützen. Die nach dem Krieg verfolgten Rechtfertigungsstrategien und die mangelhafte Aufarbeitung der eigenen Rolle im „Dritten Reich“ hinderten hohe Beamte der Sozialversicherung nicht daran, ihre Karrieren in der Sozialverwaltung der Bundesrepublik fortzuführen.
Abstract
Anti-Jewish policy and its coming to terms with the past. The work of the social security department of the Reich Ministry of Labour in Nazi Germany
The article examines the pension insurance policy of the Reich Ministry of Labour in Nazi Germany. On the one hand, it shows how the pension insurance has been used to generate additional workforces for the labour market. The pension insurance was completely aligned by the legislation of the Reich Ministry of Labour on the requirements of the National Socialist labour service. On the other hand, it highlights discrimination against Jewish insurants and pensioners. The responsible civil servants of the Reich Ministry of Labour and the pension insurance providers used their possibilities to pursue and support the goals of the Nazi regime. The justification strategies pursued after the war and the inadequate working up of one’s own role in Nazi Germany did not preventhigh civil servants from continuing their careers in the social administration of the Federal Republic of Germany.
A BIBLIOMETRIC DATA ANALYSIS OF MULTI-CRITERIA DECISION MAKING METHODS IN HERITAGE BUILDINGS
Authors: Morkūnaitė Žydrūnė , Kalibatas Darius , Kalibatienė Diana
Published: February 2019

Numerous countries are trying to find the best solution for conservation, restoration or reuse of the heritage buildings, preserving their cultural, historical, ethnic and spiritual values. The scientists, researchers and government are analysing the problems concerning with heritage building’s, like seismic issues, energy saving, sustainability, structures, materials and adaptive reuse. Since, heritage buildings’ reuse and preservation are characterized by multiple criteria, a multi-criteria decision making (MCDM) methods are useful in finding rational solutions for the previously mentioned problems. The current paper aims to overview papers on the MCDM approaches application in regard to heritage buildings’ reuse and preservation area. This study employs a bibliometric data analysis to explore state-of-the-art of the defined topic and an in-deep analysis – to synthesize the knowledge domain and critically evaluate a thorough literature in the analysed topic. As a result, scientific maps were created to reveal the knowledge domain of MCDM approaches in heritage buildings’ reuse and preservation. Finally, research gaps and future research directions are identified. Results of the analysis shows that till now MCDM approaches are not widely used in solving heritage buildings reuse and preservation issues. Moreover, there is luck of complex problem solving approach in cultural heritage buildings area.
Anisotropy of the Milky Way’s Stellar Halo Using K Giants from LAMOST and Gaia
Authors: Bird Sarah A. , Xue Xiang-Xiang , Liu Chao , Shen Juntai , Flynn Chris , Yang Chengqun
Published: February 2019

The anisotropy parameter β characterizes the extent to which orbits in stellar systems are predominantly radial or tangential and is likely to constrain, for the stellar halo of the Milky Way, scenarios for its formation and evolution. We have measured β as a function of Galactocentric radius from 5 to 100 kpc for 7664 metal-poor ([Fe/H] < −1.3) halo K giants from the LAMOST catalog with line-of-sight velocities and distances, matched to proper motions from the second Gaia data release. We construct full 6D positions and velocities for the K giants to directly measure the three components of the velocity dispersion (σ

r
, σ

θ
, σ

ϕ
) (in spherical coordinates). We find that the orbits in the halo are radial over our full Galactocentric distance range reaching over 100 kpc. The anisotropy remains remarkably unchanged with Galactocentric radius from approximately 5–25 kpc, with an amplitude that depends on the metallicity of the stars, dropping from β ≈ 0.9 for −1.8 ≤ [Fe/H] < −1.3 (for the bulk of the stars) to β ≈ 0.6 for the lowest metallicities ([Fe/H] < −1.8). Considering our sample as a whole, β ≈ 0.8 and beyond 25 kpc, the orbits gradually become less radial and anisotropy decreases to β < 0.3 past 100 kpc. Within 8 kpc, β < 0.8. The measurement of anisotropy is affected by substructure and streams, particularly beyond a Galactocentric distance of approximately 25 kpc, where the Sagittarius stream is prominent in the data. These results are complimentary to recent analysis of simulations by Loebman et al. and of SDSS/Gaia DR1 data by Belokurov et al.
Spitzer Transit Follow-up of Planet Candidates from the K2 Mission
Authors: Livingston John H. , Crossfield Ian J. M. , Werner Michael W. , Gorjian Varoujan , Petigura Erik A. , Ciardi David R. , Dressing Courtney D. , Fulton Benjamin J. , Hirano Teruyuki , Schlieder Joshua E. , Sinukoff Evan , Kosiarek Molly , Akeson Rachel , Beichman Charles A. , Benneke Björn , Christiansen Jessie L. , Hansen Bradley M. S. , Howard Andrew W. , Isaacson Howard , Knutson Heather A. , Krick Jessica , Martinez Arturo O. , Sato Bun’ei , Tamura Motohide
Published: February 2019

We present precision 4.5

Spitzer transit photometry of eight planet candidates discovered by the K2 mission: K2-52 b, K2-53 b, EPIC 205084841.01, K2-289 b, K2-174 b, K2-87 b, K2-90 b, and K2-124 b. The sample includes four sub-Neptunes and two sub-Saturns, with radii between 2.6 and 18

and equilibrium temperatures between 440 and 2000 K. In this paper we identify several targets of potential interest for future characterization studies, demonstrate the utility of transit follow-up observations for planet validation and ephemeris refinement, and present new imaging and spectroscopy data. Our simultaneous analysis of the K2 and Spitzer light curves yields improved estimates of the planet radii and multiwavelength information that helps validate their planetary nature, including the previously unvalidated candidate EPIC 205686202.01 (K2-289 b). Our Spitzer observations yield an order-of-magnitude increase in ephemeris precision, thus paving the way for efficient future study of these interesting systems by reducing the typical transit timing uncertainty in mid-2021 from several hours to a dozen or so minutes. K2-53 b, K2-289 b, K2-174 b, K2-87 b, and K2-90 b are promising radial velocity (RV) targets given the performance of spectrographs available today or in development, and the M3V star K2-124 hosts a temperate sub-Neptune that is potentially a good target for both RV and atmospheric characterization studies.