bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of an Artificial Intelligence Software for Limb Radiographic Fracture Recognition in an Emergency Department
Authors: Herpe Guillaume , Nelken Helena , Vendeuvre Tanguy , Guenezan Jeremy , Giraud Clement , Mimoz Olivier , Feydy Antoine , Tasu Jean-Pierre , Guillevin Rémy
Published: September 2024

Objectives: To assess the impact of an Artificial Intelligence (AI) limb bone fracture diagnosis software (AIS) on emergency department (ED) workflow and diagnostic accuracy. Materials and Methods: A retrospective study was conducted in two phases—without AIS (Period 1: 1 January 2020–30 June 2020) and with AIS (Period 2: 1 January 2021–30 June 2021). Results: Among 3720 patients (1780 in Period 1; 1940 in Period 2), the discrepancy rate decreased by 17% (p = 0.04) after AIS implementation. Clinically relevant discrepancies showed no significant change (−1.8%, p = 0.99). The mean length of stay in the ED was reduced by 9 min (p = 0.03), and expert consultation rates decreased by 1% (p = 0.38). Conclusions: AIS implementation reduced the overall discrepancy rate and slightly decreased ED length of stay, although its impact on clinically relevant discrepancies remains inconclusive. Key Point: After AI software deployment, the rate of radiographic discrepancies decreased by 17% (p = 0.04) but this was not clinically relevant (−2%, p = 0.99). Length of patient stay in the emergency department decreased by 5% with AI (p = 0.03). Bone fracture AI software is effective, but its effectiveness remains to be demonstrated.
Physical and Mental Components of Quality of Life after a Cardiac Rehabilitation Intervention: A Systematic Review and Meta-Analysis
Authors: Moreira José , Bravo Jorge , Aguiar Pedro , Delgado Bruno , Raimundo Armando , Boto Paulo
Published: September 2024

Background: This study aimed to analyze the effect of cardiac rehabilitation programs on the health-related quality of life of patients after a coronary cardiac event using patient-reported outcome measures (PROMs) for up to 6 months of evaluation. Methods: A comprehensive search was carried out in the MEDLINE, CINAHL, CENTRAL, and Web of Science databases for randomized controlled trials comparing the cardiac rehabilitation program with usual care. Two independent reviewers assessed the studies for inclusion, risk of bias using the Cochrane tool, and quality of evidence through the GRADE system. A meta-analysis was performed on studies assessing health-related quality of life with the SF-12 (Physical Component Summary and Mental Component Summary) up to 6 months after the program. Results: Twelve studies encompassed 2260 patients who participated in a cardiac rehabilitation program after a coronary event, with a mean age of 60.06 years. The generic PROMs used to assess quality of life were the SF-12, SF-36, EQ-5D-3L, EQ-5D-5L, and GHQ, and the specific coronary heart disease PROMs were MacNew and HeartQoL. There was a positive effect of participation in cardiac rehabilitation on the physical component of health-related quality of life at 6 months (MD [7.02]; p = 0.04] and on the mental component (MD [1.06]; p = 0.82) after applying the SF-12. Conclusions: This study highlights the significant benefits of cardiac rehabilitation programs on health-related quality of life, particularly in the physical domain at 6 months. Assessing outcomes over time through PROMs after coronary heart events is essential, thus making it possible to personalize patients’ care and improve their health status.
Enteric Nervous System and Its Relationship with Neurological Diseases
Authors: Luesma María José , López-Marco Liberto , Monzón Marta , Santander Sonia
Published: September 2024

The enteric nervous system (ENS) is a fundamental component of the gastrointestinal system, composed of a vast network of neurons and glial cells. It operates autonomously but is interconnected with the central nervous system (CNS) through the vagus nerve. This communication, known as the gut–brain axis, influences the bidirectional communication between the brain and the gut. Background/Objectives: This study aimed to review neurological pathologies related to the ENS. Methods: To this end, a comprehensive literature search was conducted in the “PubMed” database. Articles available in “free format” were selected, applying the filters “Humans” and limiting the search to publications from the last ten years. Results: The ENS has been linked to various neurological diseases, from autism spectrum disorder to Parkinson’s disease including neurological infection with the varicella zoster virus (VZV), even sharing pathologies with the CNS. This finding suggests that the ENS could serve as an early diagnostic marker or therapeutic target for neurological diseases. Gastrointestinal symptoms often precede CNS symptoms, and the ENS’s accessibility aids in diagnosis and treatment. Parkinson’s patients may show intestinal lesions up to twenty years before CNS symptoms, underscoring the potential for early diagnosis. However, challenges include developing standardized diagnostic protocols and the uneven distribution of dopaminergic neurons in the ENS. Continued research is needed to explore the ENS’s potential in improving disease prognosis. Conclusions: The ENS is a promising area for early diagnosis and therapeutic development. Nevertheless, it is essential to continue research in this area, especially to gain a deeper understanding of its organization, function, and regenerative capacity.
Liver Cirrhosis: The Immunocompromised State
Authors: Rodríguez-Negrete Elda Victoria , Gálvez-Martínez Marisol , Sánchez-Reyes Karina , Fajardo-Felix Carlos Fernando , Pérez-Reséndiz Karla Erika , Madrigal-Santillán Eduardo Osiris , Morales-González Ángel , Morales-González José Antonio
Published: September 2024

Systemic inflammation and immunodeficiency are important components of cirrhosis-associated immune dysfunction (CAID), the severity of which is dynamic, progressive, and associated with the greater deterioration of liver function. Two inflammation phenotypes have been described: low-grade and high-grade systemic inflammation. Both of these phenotypes are related to liver cirrhosis function; thus, high-grade inflammation is correlated with the severity of hepatic insufficiency, bacterial translocation, and organic insufficiency, with which the risk of infections increases and the prognosis worsens. Bacterial translocation (BT) plays a relevant role in persistent systemic inflammation in patients with cirrhosis, and the prophylactic employment of antibiotics is useful for reducing events of infection and mortality.
Goal-Directed Fluid Therapy Using Pulse Pressure Variation in Thoracic Surgery Requiring One-Lung Ventilation: A Randomized Controlled Trial
Authors: Punzo Giovanni , Beccia Giovanna , Cambise Chiara , Iacobucci Tiziana , Sessa Flaminio , Sgreccia Mauro , Sacco Teresa , Leone Angela , Congedo Maria Teresa , Meacci Elisa , Margaritora Stefano , Sollazzi Liliana , Aceto Paola
Published: September 2024

Background: Intraoperative fluid management based on pulse pressure variation has shown potential to reduce postoperative pulmonary complications (PPCs) and improve clinical outcomes in various surgical settings. However, its efficacy and safety have not been assessed in patients undergoing thoracic surgery with one-lung ventilation. Methods: Patients scheduled for pulmonary lobectomy using uniportal video-assisted thoracic surgery approach were randomly assigned to two groups. In the PPV group, fluid administration was guided by the pulse pressure variation parameter, while in the near-zero group, it was guided by conventional hemodynamic parameters. The primary outcome was the partial pressure of oxygen (PaO2)/ fraction of inspired oxygen (FiO2) ratio 15 min after extubation. The secondary outcomes included extubation time, the incidence of postoperative pulmonary complications in the first three postoperative days, and the length of hospital stay. Results: The PaO2/FiO2 ratio did not differ between the two groups (364.48 ± 38.06 vs. 359.21 ± 36.95; p = 0.51), although patients in the PPV group (n = 44) received a larger amount of both crystalloids (1145 ± 470.21 vs. 890 ± 459.31, p = 0.01) and colloids (162.5 ± 278.31 vs 18.18 ± 94.68, p = 0.002) compared to the near-zero group (n = 44). No differences were found in extubation time, type and number of PPCs, and length of hospital stay. Conclusions: PPV-guided fluid management in thoracic surgery requiring one-lung ventilation does not improve pulmonary gas exchange as measured by the PaO2/FiO2 ratio and does not seem to offer clinical benefits. Additionally, it results in increased fluid administration compared to fluid management based on conventional hemodynamic parameters.
Research Interest in Copper Materials for Caries Management: A Bibliometric Analysis
Authors: Xu Veena Wenqing , Nizami Mohammed Zahedul Islam , Yin Iris Xiaoxue , Niu John Yun , Yu Ollie Yiru , Chu Chun-Hung
Published: September 2024

This study examined research interest in copper materials for caries management. We conducted an exhaustive literature search of English publications on copper materials for caries management. We removed duplicate publications and screened the titles and abstracts to identify relevant publications. Then, we analyzed the bibliometric data of the publications using the Bibliometrix and VOSviewer programs. This study included 75 laboratory studies, six clinical trials, and 17 reviews. Most of the original research studied copper or copper oxide nanoparticles (45/81, 56%). The materials could be doped into topical agents, restorative fillers, dental adhesives, dental implants, and orthodontic appliances. Since the first paper was published in 1980, publication counts gradually increased and surged in 2019. Among publications on copper materials for caries management, the publication counts and citations from 2019 to 2024 accounted for 65% (64/98) and 74% (1677/2255) over the last 45 years. Cocitation analysis revealed that the two main keywords were nanoparticles and antibacterial activity, and their burst strengths (period) were 3.84 (2021–2024) and 2.21 (2020–2021). The topics of the top two publications with the highest citation burst strength (period) are the antimicrobial effect of copper oxide nanoparticles (3.14, 2021–2022) and the dental application of copper nanoparticles (2.84, 2022–2024). In conclusion, this study revealed a growing interest in copper materials for caries management.
Improvements in Clinical Cancer Care Associated with Integration of Personalized Medicine
Authors: Agarwal Arushi , Pritchard Daryl , Winzeler Alissa , Mohammed Hina , Brown Thomas D. , Gustavsen Gary G.
Published: September 2024

Background: While adoption of personalized medicine (PM) continues to increase in clinical oncology, there is limited data connecting the level of PM adoption at a given institution to improved clinical outcomes for patients. The purpose of this study was to analyze the correlation between health care providers’ scores on a previously described PM integration framework and two outcome measures: the use of targeted therapy and clinical trial enrollment. Methods: This study was conducted using real-world data (RWD) from the Syapse® Learning Health Network (LHN). The PM integration score for six community hospital systems in the LHN was calculated and subsequently correlated with the two outcome measures. Results: Across six institutions, a strong correlation between PM integration score and targeted therapy use was observed in metastatic non-small cell lung cancer (mNSCLC) (R2 = 0.81), an indication with a significant number of approved targeted agents. Conversely, a strong correlation between PM integration score and clinical trial enrollment was observed in metastatic triple-negative breast cancer (TNBC) (R2 = 0.63), an indication with fewer marketed targeted therapies but an active targeted therapy pipeline. Conclusion: The results in these cases suggest that PM integration is a strong indicator of high-quality care practices for both utilization of targeted therapy in more mature PM indications (e.g., mNSCLC) and clinical trial enrollment in more emerging PM indications (e.g., TNBC).
Balancing Economic Growth, Carbon Emissions, and Sequestration: A Multi-Objective Spatial Optimization in Zhengzhou Metropolitan Area in China
Authors: Fu Mengze , Ban Kangjia , Jin Li , Wu Di
Published: September 2024

As China’s “Dual Carbon” strategy is implemented and the new urbanization advances, balancing economic development, emission reduction, and carbon sequestration has become an important issue during the growth of emerging metropolitan areas, and it is also important for achieving high-quality urban development. Therefore, this study had three major objective functions: economic growth, carbon emission reduction, and increased carbon storage. The multi-objective land use quantity structure was solved using the Non-dominated Sorting Genetic Algorithm II (NSGA-II), and the best solution in the solution set was introduced using the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) for evaluation. Finally, combined with the Future Land Use Simulation (FLUS) model, the low-carbon evolution of the metropolitan area was predicted on a spatial scale. The trade-off plan results show that by 2035, the economic benefits will reach CNY 7.65 trillion, carbon emissions will be kept under 99.24 million tons, and carbon storage will steadily increase by 15.2 million tons. Therefore, optimizing land use from the perspective of balancing carbon emissions, carbon sequestration, and economic development can provide valuable references for planning low-carbon development and the rational use of spatial resources in future metropolitan areas.
Anti-Inflammatory and Wound Healing Properties of Different Honey Varieties from Romania and Correlations to Their Composition
Authors: Iosageanu Andreea , Stefan Laura Mihaela , Craciunescu Oana , Cimpean Anisoara
Published: September 2024

The complex composition of honey plays a crucial role in wound healing, exhibiting varying effects at different stages of the healing process. This study investigated seven honey varieties sourced from different regions of Romania using in vitro experimental models developed in macrophage-like, fibroblast, and keratinocyte cell lines to explore the mechanisms by which honey promoted the healing process. This study assessed the impact of honey on inflammatory cytokine production in macrophage-like cells, cell proliferation and collagen synthesis in fibroblasts, and cell proliferation and migration in keratinocytes. Additionally, correlation analysis was conducted to examine the relationship between honey composition and its biological properties. Honey varieties presented both anti- and pro-inflammatory effects. Moreover, they displayed dose-dependent pro-proliferative effects, stimulating collagen synthesis and cell migration, thereby enhancing the re-epithelialization process. The Pearson coefficient analysis indicated a strong positive correlation between biological activities and phenolic content. Additionally, there was a medium positive correlation with the ascorbic acid content and a medium negative correlation with the glucose content in the different honey varieties. Romanian honey varieties rich in phenolics showed potential in modulating inflammation, proliferation, collagen synthesis, and cell migration, suggesting their suitability for further evaluation and development of innovative dressings for skin tissue regeneration.
Environmentally Acceptable Lubricants for Stern Tube Application: Shear Stability and Friction Factor
Authors: Večeř Marek , Stavárek Petr , Krčková Simona , Zelenka Ladislav , Armada Sergio
Published: September 2024

Stern tube lubricants are essential in maritime operations, safeguarding ship propeller shafts from wear and corrosion while ensuring efficient propulsion. Their role in reducing friction and maintaining system integrity is critical. With growing environmental concerns, the adoption of environmentally acceptable lubricants (EALs) for stern tubes has gained importance, balancing operational performance with environmental protection. This study investigates the rheological and tribological properties of EALs formulated for ship propeller stern tube applications. The primary focus is on comparing these EALs with conventional mineral oils to assess their suitability in marine environments. EALs are increasingly favored due to their biodegradability and reduced environmental impact. Key parameters such as shear stability, friction factor, and temperature dependency were evaluated using a range of experimental methods including rotational viscometry and tribological analysis. The results indicate that the newly formulated EALs based on synthetic esters exhibit the highest viscosity index, a higher range of shear stability, and lower friction factors, compared to commercially available mineral oils, especially under varying operational conditions. These findings contribute to the ongoing efforts to promote eco-friendly lubricants in maritime industries, aligning with global environmental protection initiatives.
Impact of Annealing in Various Atmospheres on Characteristics of Tin-Doped Indium Oxide Layers towards Thermoelectric Applications
Authors: Kaźmierczak-Bałata Anna , Bodzenta Jerzy , Szperlich Piotr , Jesionek Marcin , Michalewicz Anna , Domanowska Alina , Mayandi Jeyanthinath , Venkatachalapathy Vishnukanthan , Kuznetsov Andrej
Published: September 2024

The aim of this work was to investigate the possibility of modifying the physical properties of indium tin oxide (ITO) layers by annealing them in different atmospheres and temperatures. Samples were annealed in vacuum, air, oxygen, nitrogen, carbon dioxide and a mixture of nitrogen with hydrogen (NHM) at temperatures from 200 °C to 400 °C. Annealing impact on the crystal structure, optical, electrical, thermal and thermoelectric properties was examined. It has been found from XRD measurements that for samples annealed in air, nitrogen and NHM at 400 °C, the In2O3/In4Sn3O12 share ratio decreased, resulting in a significant increase of the In4Sn3O12 phase. The annealing at the highest temperature in air and nitrogen resulted in larger grains and the mean grain size increase, while vacuum, NHM and carbon dioxide atmospheres caused the decrease in the mean grain size. The post-processing in vacuum and oxidizing atmospheres effected in a drop in optical bandgap and poor electrical properties. The carbon dioxide seems to be an optimal atmosphere to obtain good TE generator parameters—high ZT. The general conclusion is that annealing in different atmospheres allows for controlled changes in the structure and physical properties of ITO layers.
Enhanced Water Resistance of TiO2–GO–SMS-Modified Soil Composite for Use as a Repair Material in Earthen Sites
Authors: Li Wei , Bao Wenbo , Huang Zhiqiang , Li Yike , Guo Yuxuan , Wang Ming
Published: September 2024

Most earthen sites are located in open environments eroded by wind and rain, resulting in spalling and cracking caused by shrinkage due to constant water absorption and loss. Together, these issues seriously affect the stability of such sites. Gypsum–lime-modified soil offers relatively strong mechanical properties but poor water resistance. If such soil becomes damp or immersed in water, its strength is significantly reduced, making it unviable for use as a material in the preparation of earthen sites. In this study, we achieved the composite addition of a certain amount of sodium methyl silicate (SMS), titanium dioxide (TiO2), and graphene oxide (GO) into gypsum–lime-modified soil and analyzed the microstructural evolution of the composite-modified soil using characterization methods such as XRD, SEM, and EDS. A comparative study was conducted on changes in the mechanical properties of the composite-modified soil and original soil before and after immersion using water erosion, unconfined compression (UCS), and unconsolidated undrained (UU) triaxial compression tests. These analyses revealed the micro-mechanisms for improving the waterproof performance of the composite-modified soil. The results showed that the addition of SMS, TiO2, and GO did not change the crystal structure or composition of the original soil. In addition, TiO2 and GO were evenly distributed between the modified soil particles, playing a positive role in filling and stabilizing the structure of the modified soil. After being immersed in water for one hour, the original soil experienced structural instability leading to collapse. While the water absorption rate of the composite-modified soil was only 0.84%, its unconfined compressive strength was 4.88 MPa (the strength retention rate before and after immersion was as high as 93.1%), and the shear strength was 614 kPa (the strength retention rate before and after immersion was as high as 96.7%).
Enhanced Minor Ginsenoside Contents of Nano-Sized Black Korean Ginseng through Hot Melt Extrusion
Authors: Lee Junho , Lee Ha-Yeon , Baek Jong-Suep
Published: September 2024

Black ginseng (BG), a traditional medicinal herb produced through a nine-stage steaming and drying process, exhibits stronger pharmacological efficacy, including antioxidant, anti-inflammatory, and anti-cancer properties, when compared to white and red ginseng. The ginsenosides in BG are classified as major and minor types, with minor ginsenosides demonstrating superior pharmacological properties. However, their low concentrations limit their availability for research and clinical applications. In this study, hot melt extrusion (HME) was utilized as an additional processing technique to enhance the content of minor ginsenoside in BG, and the physicochemical properties of the formulation were analyzed. Ginsenoside content in BG and HME-treated BG (HME-BG) was analyzed using high-performance liquid chromatography (HPLC), while their physicochemical properties were evaluated through dynamic light scattering (DLS), electrophoretic light scattering (ELS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FT-IR). HME treatment resulted in a significant increase in minor ginsenosides Rg3 and compound K (CK) by 330% and 450%, respectively, while major ginsenosides Rg1 and Rb1 decreased or were not detected. Additionally, HME-BG demonstrated reduced particle size, improved PDI, and decreased crystallinity. HME treatment effectively converts major ginsenosides in BG into minor ginsenosides, enhancing its pharmacological efficacy and showing great potential for research and development applications.
Recycling of Polyurethane Foams via Glycolysis: A Review
Authors: Wieczorek Kinga , Bukowski Przemysław , Stawiński Krystian , Ryłko Iwona
Published: September 2024

Polyurethane foams constitute highly problematic waste due to their low density and consequently large volume. Among the most promising recycling approaches, the glycolysis of polyurethane waste stands out and was extensively discussed in this article. Existing literature reviews lack a detailed analysis of glycolysis processes and a clear presentation of the most important data. However, in this review, the scientific literature on glycolysis has been thoroughly examined and updated with the latest research in the field. The article provides an overview of glycolysis methods, categorized into rigid and flexible foams, along with a review of the catalysts and process conditions employed. Additionally, this study offers a comprehensive analysis of industrial methods protected by active patents, which has not been previously explored in the literature. This detailed examination of patent information adds significant value to the review and distinguishes it from others. Furthermore, this review also aims to introduce the main types of polyurethanes and their properties. It outlines the fundamentals of recycling strategies, thermomodernization trends, and environmental considerations, highlighting the critical role of recycling in the industry. The article serves as a complete foundation for exploring new alternative methods in this field.
Study on Prestressed Concrete Beams Strengthened with External Unbonded CFRP Tendons
Authors: Chen Longlong , Qiang Xuhong , Jiang Xu , Dong Hao , Chen Wulong
Published: September 2024

This study builds a refined finite element (FE) model to research the flexural behavior of a reinforced beam with prestressed CFRP tendons. The precision of the FE model is validated through a comparison with the experimental outcomes. The numerical findings align well with the experimental outcomes, encompassing the failure mode, load-deflection curve, load-strain curves of concrete, steel reinforcements and CFRP tendons. The variances between predicted values and experimental results are within 10%. Leveraging the verified FE model, an extensive parametric study has been carried out to examine the effects of various parameters, including the CFRP tendon prestress, the CFRP tendon diameter, the deviator layout, the anchorage height and the prestressing strand prestress. Leveraging the findings from the parametric study, some refined design recommendations are proposed for practical reinforcement applications: Increasing the CFRP tendon prestress in practical reinforcement designs is recommended; CFRP tendons with larger diameters are recommended for use in practical reinforcement designs; Employing a linear CFRP tendon profile for reinforcement is not considered optimal in practical applications; The prestress loss in the prestressing strands of PC beams should be considered in practice.
Kinetics of Iron Nitride Layer Growth during the Nitriding of AISI 1085 Non-Alloy Steel and AISI 52100 Alloy Steel
Authors: Frączek Tadeusz , Prusak Rafał , Michalski Jerzy , Kowalewska-Groszkowska Magdalena
Published: September 2024

This paper presents a comparison of two-component ammonia-based inlet atmospheres diluted with either hydrogen (NH3/H2) or nitrogen (NH3/N2). Taking advantage of the features of inlet atmospheres diluted with nitrogen and hydrogen, four two-stage processes were designed and carried out, which were juxtaposed with two single-stage processes carried out only in an NH3 atmosphere. A common parameter of the processes carried out was the same value of nitrogen availability in each process stage. The gas nitriding process was carried out on ASIS 1085 non-alloy steel and ASIS 52100 alloy steel. It was found that the chemical composition of the steels studied, for the adopted nitriding process parameters, did not affect the kinetics of the growth in the mass of nitrided samples as a function of the nitriding time. However, the additions of alloying elements present in the steels studied significantly affected the nitrogen distribution between the resulting iron nitride layer and the diffusion zone in the nitrided substrate. Because of the presence of chromium in AISI 52100 steel, a larger mass of nitrogen accumulated in the nitriding zone in the solution compared with unalloyed AISI 1085 steel. As a result, with the same increase in the mass of nitrided steel, a thicker layer of iron nitrides formed on AISI 1085 steel than on AISI 52100 steel.
The Effect of Incorporating Dimethylaminohexadecyl Methacrylate and/or 2-Methacryloyloxyethyl Phosphorylcholine on Flexural Strength and Surface Hardness of Heat Polymerized and 3D-Printed Denture Base Materials
Authors: AlAzzam Njood F. , Bajunaid Salwa O. , Mitwalli Heba A. , Baras Bashayer H. , Weir Michael D. , Xu Hockin H. K.
Published: September 2024

Background: A major disadvantage of polymethyl methacrylate (PMMA) acrylic resins is susceptibility to biofilm accumulation. The incorporation of antimicrobial agents is a reliable prevention technique. The purpose of this study is to investigate the effect of incorporating dimethylaminohexadecyl methacrylate (DMAHDM) and/or 2-methacryloyloxyethyl phosphorylcholine (MPC) into heat-polymerized (HP) and 3D-printed (3DP) denture base materials on the flexural strength, modulus of elasticity, and surface hardness. Methods: DMAHDM and/or MPC were mixed with the acrylic resin liquid of a heat-polymerized (ProBase Hot) and a 3D printed (NextDent Denture 3D) material at mass fractions of 1.5% and 3% and a combination of 3% MPC and 1.5% DMAHDM. Results: Significant differences in mechanical properties between the control and experimental groups have been detected (p-value < 0.0001). In HP materials, the addition of DMAHDM and/or MPC generally decreased the flexural strength, from (151.18 MPa) in G1 down to (62.67 MPa) in G5, and surface hardness, from (18.05 N/mm2) down to (10.07 N/mm2) in G5. Conversely, in 3DP materials, flexural strength was slightly enhanced, from (58.22 MPa) in G1 up to (62.76 MPa) in G6, although surface hardness was consistently reduced, from (13.57 N/mm2) down to (5.29 N/mm2) in G5. Conclusion: It is recommended to carefully optimize the concentrations of DMAHDM and/or MPC to maintain mechanical integrity.
A Novel Ensemble Method of Divide-and-Conquer Markov Boundary Discovery for Causal Feature Selection
Authors: Li Hao , Zhan Jianjun , Wang Haosen , Zhao Zipeng
Published: September 2024

The discovery of Markov boundaries is highly effective at identifying features that are causally related to the target variable, providing strong interpretability and robustness. While there are numerous methods for discovering Markov boundaries in real-world applications, no single method is universally applicable to all datasets. Therefore, in order to balance precision and recall, we propose an ensemble framework of divide-and-conquer Markov boundary discovery algorithms based on U-I selection strategy. We put three divide-and-conquer Markov boundary methods into the framework to obtain an ensemble algorithm, focusing on judging controversial parent–child variables to further balance precision and recall. By combining multiple algorithms, the ensemble algorithm can leverage their respective strengths and more thoroughly analyze the cause-and-effect relationships of target variables through various perspectives. Furthermore, it can enhance the robustness of the algorithm and reduce dependence on a single algorithm. In the experiment, we select four advanced Markov boundary discovery algorithms as comparison algorithms and compare them on nine benchmark Bayesian networks and three real-world datasets. The results show that EDMB ranks first in the overall ranking, which illustrates the superiority of the integrated algorithm and the effectiveness of the adopted U-I selection strategy. The main contribution of this paper lies in proposing an ensemble framework for divide-and-conquer Markov boundary discovery algorithms, balancing precision and recall through the U-I selection strategy, and judging controversial parent–child variables to enhance algorithm performance and robustness. The advantage of the U-I selection strategy and its difference from existing methods is the ability to independently obtain the maximum precision and recall of multiple algorithms within the ensemble framework. By assessing controversial parent–child variables, it further balances precision and recall, leading to results that are closer to the true Markov boundary.
On Non-Commutative Multi-Rings with Involution
Authors: Roberto Kaique M. A. , Santos Kaique R. P. , Mariano Hugo Luiz
Published: September 2024

The primary motivation for this work is to develop the concept of Marshall’s quotient applicable to non-commutative multi-rings endowed with involution, expanding upon the main ideas of the classical case—commutative and without involution—presented in Marshall’s seminal paper. We define two multiplicative properties to address the involutive case and characterize their Marshall quotient. Moreover, this article presents various cases demonstrating that the “multi” version of rings with involution offers many examples, applications, and relatives in (multi)algebraic structures. Therefore, we established the first steps toward the development of an expansion of real algebra and real algebraic geometry to a non-commutative and involutive setting.
Graph Neural Networks for Mesh Generation and Adaptation in Structural and Fluid Mechanics
Authors: Pelissier Ugo , Parret-Fréaud Augustin , Bordeu Felipe , Mesri Youssef
Published: September 2024

The finite element discretization of computational physics problems frequently involves the manual generation of an initial mesh and the application of adaptive mesh refinement (AMR). This approach is employed to selectively enhance the accuracy of resolution in regions that encompass significant features throughout the simulation process. In this paper, we introduce Adaptnet, a Graph Neural Networks (GNNs) framework for learning mesh generation and adaptation. The model is composed of two GNNs: the first one, Meshnet, learns mesh parameters commonly used in open-source mesh generators, to generate an initial mesh from a Computer Aided Design (CAD) file; while the second one, Graphnet, learns mesh-based simulations to predict the components of an Hessian-based metric to perform anisotropic mesh adaptation. Our approach is tested on structural (Deforming plate–Linear elasticity) and fluid mechanics (Flow around cylinders–steady-state Stokes) problems. Our findings demonstrate the model’s ability to precisely predict the dynamics of the system and adapt the mesh as needed. The adaptability of the model enables learning resolution-independent mesh-based simulations during training, allowing it to scale effectively to more intricate state spaces during inference.
Rice Varieties Intercropping Induced Soil Metabolic and Microbial Recruiting to Enhance the Rice Blast (Magnaporthe Oryzae) Resistance
Authors: Zhu Xiao-Qiao , Li Mei , Li Rong-Ping , Tang Wen-Qiang , Wang Yun-Yue , Fei Xiao , He Ping , Han Guang-Yu
Published: September 2024

[Background] Intercropping is considered an effective approach to defending rice disease. [Objectives/Methods] This study aimed to explore the resistance mechanism of rice intraspecific intercropping by investigating soil metabolites and their regulation on the rhizosphere soil microbial community using metabolomic and microbiome analyses. [Results] The results showed that the panicle blast disease occurrence of the resistant variety Shanyou63 (SY63) and the susceptible variety Huangkenuo (HKN) were both decreased in the intercropping compared to monoculture. Notably, HKN in the intercropping system exhibited significantly decreased disease incidence and increased disease resistance-related enzyme protease activity. KEGG annotation from soil metabolomics analysis revealed that phenylalanine metabolic pathway, phenylalanine, tyrosine, and tryptophan biosynthesis pathway, and fructose and mannose metabolic pathway were the key pathways related to rice disease resistance. Soil microbiome analysis indicated that the bacterial genera Nocardioides, Marmoricola, Luedemannella, and Desulfomonile were significantly enriched in HKN after intercropping, while SY63 experienced a substantial accumulation of Ruminiclostridium and Cellulomonas. Omics-based correlation analysis highlighted that the community assembly of Cellulomonas and Desulfomonile significantly affected the content of the metabolites D-sorbitol, D-mannitol, quinic acid, which further proved that quinic acid had a significantly inhibitory effect on the mycelium growth of Magnaporthe oryzae, and these three metabolites had a significant blast control effect. The optimal rice blast-control efficiency on HKN was 51.72%, and Lijiangxintuanheigu (LTH) was 64.57%. [Conclusions] These findings provide a theoretical basis for rice varieties intercropping and sustainable rice production, emphasizing the novelty of the study in elucidating the underlying mechanisms of intercropping-mediated disease resistance.
Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy
Authors: Brito Nunes Caroline , Borges Maria Carolina , Freathy Rachel M. , Lawlor Deborah A. , Qvigstad Elisabeth , Evans David M. , Moen Gunn-Helen
Published: September 2024

Background/Objectives: During pregnancy, physiological changes in maternal circulating glucose levels and its metabolism are essential to meet maternal and fetal energy demands. Major changes in glucose metabolism occur throughout pregnancy and consist of higher insulin resistance and a compensatory increase in insulin secretion to maintain glucose homeostasis. For some women, this change is insufficient to maintain normoglycemia, leading to gestational diabetes mellitus (GDM), a condition characterized by maternal glucose intolerance and hyperglycaemia first diagnosed during the second or third trimester of pregnancy. GDM is diagnosed in approximately 14.0% of pregnancies globally, and it is often associated with short- and long-term adverse health outcomes in both mothers and offspring. Although recent studies have highlighted the role of genetic determinants in the development of GDM, research in this area is still lacking, hindering the development of prevention and treatment strategies. Methods: In this paper, we review recent advances in the understanding of genetic determinants of GDM and glycaemic traits during pregnancy. Results/Conclusions: Our review highlights the need for further collaborative efforts as well as larger and more diverse genotyped pregnancy cohorts to deepen our understanding of the genetic aetiology of GDM, address research gaps, and further improve diagnostic and treatment strategies.
Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics
Authors: Huang Yuanfeng , Liang Mingjie , Liao Yiwen , Ji Zirui , Lin Wanfen , Pu Xiangjin , Wang Lexun , Wang Weixuan
Published: September 2024

This study focused on exploring the effects of SW033291, an inhibitor of 15-hydroxyprostaglandin dehydrogenase, on type 2 diabetes mellitus (T2DM) mice from a comprehensive perspective. Studies have demonstrated that SW033291 benefits tissue repair, organ function, and muscle mass in elderly mice. Our recent investigation initially reported the beneficial effect of SW033291 on T2DM progression. Herein, we used a T2DM mouse model induced by a high-fat diet and streptozotocin injection. Then, serum and liver metabolomics, as well as liver transcriptomic analyses, were performed to provide a systematic perspective of the SW033291-ameliorated T2DM. The results indicate SW033291 improved T2DM by regulating steroid hormone biosynthesis and linoleic/arachidonic acid metabolism. Furthermore, integrated transcriptomic and metabolomic analyses suggested that key genes and metabolites such as Cyp2c55, Cyp3a11, Cyp21a1, Myc, Gstm1, Gstm3, 9,10-dihydroxyoctadecenoic acid, 11-dehydrocorticosterone, and 12,13-dihydroxy-9Z-octadecenoic acid played crucial roles in these pathways. qPCR analysis validated the significant decreases in the hepatic gene expressions of Cyp2c55, Cyp3a11, Myc, Gstm1, and Gstm3 in the T2DM mice, which were reversed following SW033291 treatment. Meanwhile, the elevated mRNA level of Cyp21a1 in T2DM mice was decreased after SW033291 administration. Taken together, our findings suggest that SW033291 has promising potential in alleviating T2DM and could be a novel therapeutic candidate.
The Side-Release Method Measures the High-Pressure Sound Velocity of Iron Using Line-Spatially Resolved DISAR
Authors: Chen Long , Liu Cangli , Tang Longhuang , Ma Heli , Jia Xing , Tao Tianjiong , Liu Shenggang , Chen Yongchao , Wang Xiang , Wu Jian , Li Chengjun , Liu Dameng , Weng Jidong , Liu Huan
Published: September 2024

The study of high-pressure sound velocity is an important part of shock wave physics, and the study of ultra-high pressure sound velocity of iron is of great significance to many research fields such as geophysics, solid state physics, and crystallography. At present, the measurement of sound velocity is usually carried out by the catch-up sparse wave method and windowed VISAR technology, which is complex in structure and not highly adaptable. In particular, for the ultra-high pressure sonic velocity measurement of metals, it is limited by the loading platform and window materials and cannot realize the high temperature and high-pressure environment of the earth’s inner core. In this paper, the sound velocity measurement of iron under high temperature and high-pressure environment (78 GPa) is realized based on the two-stage light gas cannon experimental platform. The side-side sparse wave method was used to establish a coupling model of high-spatially resolved optical group and fiber bundle. A multiplexed all-fiber laser interferometry velocity measurement system (DISAR) was built, and the spatial resolution was better than 20 μm. In this paper, we will provide a feasible route for a method for measuring the high spatiotemporal resolution velocity.
Fluidal Peperites Recorded in the Cretaceous Lacustrine Sediments in the Southern Korean Peninsula: Syn-Magmatic Sediment Fluidization and Its Influence on the Peperite Formation
Authors: Kim Min-Cheol , Gihm Yong Sik
Published: September 2024

This study assessed the influence of sediment and water redistribution in host sediments on peperite formation by examining the peperites at the boundary between Cretaceous lacustrine sedimentary successions and intruding dikes (D1 and D2). The peperite zones occur along the dike margins and consist of fluidal juvenile fragments, classified as Type A and Type B perperite zones based on lateral extent of the peperite zones. Type A peperite zone, the dominant type, exhibites a narrow distribution (<20 cm), whereas Type B peperite zone sporadically occurs along D1 with a wider width (<1 m). Type B peperite zone is laterally linked with clastic dikes. These dikes containi fluidal shaped dike fragments with jigsaw-fit textures, indicating syn-magmatic fluidization and the resultant formation of the clastic dike via heat transfer. During dike emplacement, the interaction between the host sediments and the intruding magma formed Type A along the margins. Simultaneously, the clastic dikes, composed of fluidized sediments and water, supplied additional water and sediments, enhancing magma-host sediment intermingling and leading to the wide lateral extent of Type B. Our findings demonstrate that sediment and water redistribution via syn-magmatic fluidization is crucial in peperite formation, influencing the initial processes of phreatomagmatic volcanism.
The Final Step in Molybdenum Cofactor Biosynthesis—A Historical View
Authors: Mendel Ralf R. , Oliphant Kevin D.
Published: September 2024

Molybdenum (Mo) is an essential micronutrient across all kingdoms of life, where it functions as a key component of the active centers of molybdenum-dependent enzymes. For these enzymes to gain catalytic activity, Mo must be complexed with a pterin scaffold to form the molybdenum cofactor (Moco). The final step of Moco biosynthesis is catalyzed by the enzyme Mo-insertase. This review focuses on eukaryotic Mo-insertases, with an emphasis on those found in plants and mammals, which have been instrumental in advancing the understanding of Mo biochemistry. Additionally, a historical perspective is provided, tracing the discovery of Mo-insertase from the early 1960s to the detailed characterization of its reaction mechanism in 2021. This review also highlights key milestones in the study of Mo-insertase, including mutant characterization, gene cloning, structural elucidation at the atomic level, functional domain assignment, and the spatial organization of the enzyme within cellular protein networks.
Gas-Phase Studies of NMR Shielding and Indirect Spin–Spin Coupling in 13C-Enriched Ethane and Ethylene
Authors: Wilczek Marcin , Jackowski Karol
Published: September 2024

13C and 1H NMR spectra were observed as the function of density in 1,2-13C-enriched ethane and ethylene for the pure gaseous compounds and their binary mixtures with xenon and carbon dioxide gases as the solvents. All the chemical shifts and indirect spin–spin couplings were linearly dependent on the solvent density. The appropriate NMR parameters (σ and nJ) in isolated 13C2H6 and 13C2H4 molecules and the coefficients responsible for the binary molecular interactions were determined and compared with previous similar measurements and selected calculated shielding data. The newly obtained 13C shielding values in the isolated ethane and ethylene molecules suggest visible secondary isotope effects due to the additional carbon-13 atom. All the investigated shielding parameters depend on intermolecular interactions, and the dependence of 13C shielding is much more marked. In contrast, the indirect spin–spin couplings in 13C2H6 and 13C2H4 molecules are almost independent of solvent molecules. Their nJ values determined in liquids over sixty years ago are generally consistent with the same nJ parameters in isolated 13C2H6 and 13C2H4 molecules.
Modulation of Free Carbon Structures in Polysiloxane-Derived Ceramics for Anode Materials in Lithium-Ion Batteries
Authors: Quan Yiling , Hu Changhao , Feng Peifeng , Song Yujie , Liang Kun , Jian Xigao , Xu Jian
Published: September 2024

Polymer-derived silicon oxycarbide (SiOC) ceramics have garnered significant attention as novel silicon-based anode materials. However, the low conductivity of SiOC ceramics is a limiting factor, reducing both their rate capability and cycling stability. Therefore, controlling the free carbon content and its degree of graphitization within SiOC is crucial for determining battery performance. In this study, we regulated the free carbon content using divinylbenzene (DVB) and controlled the graphitization of free carbon with the transition metal iron (Fe). Through a simple pyrolysis process, we synthesized SiOC ceramic materials (CF) and investigated the impact of Fe-induced changes in the carbon phase and the amorphous SiOC phase on the comprehensive electrochemical performance. The results demonstrated that increasing the DVB content in the SiOC precursor enhanced the free carbon content, while the addition of Fe promoted the graphitization of free carbon and induced the formation of carbon nanotubes (CNTs). The electrochemical performance results showed that the CF electrode material exhibited a high reversible capacity of approximately 1154.05 mAh g−1 at a low current density of 100 mA g−1 and maintained good rate capability and cycling stability after 1000 cycles at a high current density of 2000 mA g−1.
A Novel Modified ZIF-8 Nanoparticle with Enhanced Interfacial Compatibility and Pervaporation Performance in a Mixed Matrix Membrane for De-Alcoholization in Low-Concentration Solutions
Authors: Xiong Yun , Shu Yifan , Deng Niyan , Luo Xiaogang , Liu Shengpeng , Wu Xiaoyu
Published: September 2024

This study investigated the enhancement in bioethanol recovery from mixed matrix membranes (MMMs) by functionalizing zeolite framework-8 (ZIF-8) with imidazolate. This study focused on the separation of ethanol from low-concentration ethanol/water mixtures (typical post-fermentation concentrations of 5–10 wt%). Specifically, ZIF-8 was modified by the shell–ligand exchange reaction (SLER) with 5,6-dimethylbenzimidazole (DMBIM), resulting in ZIF-8-DMBIM particles with improved hydrophobicity, organophilicity, larger size, and adjustable pore size. These particles were incorporated into a PEBAX 2533 matrix to produce ZIF-8-DMBIM/PEBAX MMMs using a dilution blending method. The resulting membranes showed significant performance enhancement: 8 wt% ZIF-8-DMBIM loading achieved a total flux of 308 g/m2·h and a separation factor of 16.03, which was a 36.8% increase in flux and 176.4% increase in separation factor compared with the original PEBAX membrane. In addition, performance remained stable during a 130 h cycling test. These improvements are attributed to the enhanced compatibility and dispersion of ZIF-8-DMBIM in the PEBAX matrix. In conclusion, the evaluation of nanofiller content, feed concentration, operating temperature, and membrane stability confirmed that ZIF-8-DMBIM/PEBAX MMM is ideal for ethanol recovery in primary bioethanol concentration processes.