bluuebunny/crossref_metadata_2025 huggingface dataset:
A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis
Authors: WITKO-SARSAT VERONIQUE , LESAVRE PHILIPPE , LOPEZ SANDRA , BESSOU GILLES , HIEBLOT CORINNE , PRUM BERNARD , NOËL LAURE HÉLÈNE , GUILLEVIN LOÏC , RAVAUD PHILIPPE , SERMET-GAUDELUS ISABELLE , TIMSIT JOSE , GRÜNFELD JEAN-PIERRE , HALBWACHS-MECARELLI LISE
Published: May 2021

It has been shown previously that proteinase 3 (PR3), a neutrophil intracellular protease that is the main antigen of antineutrophil cytoplasm (ANCA) autoantibodies, is present on the plasma membrane of a subset of freshly isolated neutrophils. This study shows that the size of this subset of membrane PR3-positive (mPR3+) neutrophils is a stable feature of a given individual, most likely genetically controlled. It ranges from 0 to 100% of neutrophils and allows us to define a new polymorphism in the healthy population, with three discrete phenotypes corresponding respectively to less than 20% mPR3+ neutrophils (mPR3low) or to a mean percentage of 47% (mPR3intermediate) and 71.5% (mPR3high) mPR3+ neutrophils. The frequency of the mPR3high phenotype was significantly increased in patients with ANCA-associated vasculitis (85% versus 55% in healthy subjects). The percentage of mPR3+ neutrophils was not affected by disease activity, relapses, or therapy, and did not reflect in vivo cell activation. In addition, mPR3+ phenotypes were normally distributed in cystic fibrosis patients, indicating that infection and/or inflammation per se do not lead to a high percentage of mPR3+ neutrophils. The frequency of the mPR3high phenotype was not related to anti-PR3 autoimmunization, since it was increased in vasculitic patients regardless of the ANCA specificity (anti-PR3, anti-myeloperoxidase, or unknown). Interestingly, the frequency of the mPR3high phenotype was also increased in patients with rheumatoid arthritis. It was normal in type I-diabetes, a T cell-dependent autoimmune disease. It is proposed here that a high proportion of membrane PR3-positive neutrophils could favor the occurrence or the progression of chronic inflammatory diseases.
Unrecognized Pattern of von Willebrand Factor Abnormalities in Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura
Authors: GALBUSERA MIRIAM , BENIGNI ARIELA , PARIS SIMONA , RUGGENENTI PIERO , ZOJA CARLA , ROSSI CHIARA , REMUZZI GIUSEPPE
Published: May 2021

Heterogeneous abnormalities in multimeric structure and fragmentation of endothelial-derived von Willebrand factor (vWF) have been reported in hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). This study was conducted to establish whether different patterns of vWF abnormalities were associated with different clinical syndromes. Plasmatic levels of vWF antigen (vWF:Ag), vWF release from endothelial cells (EC) exposed to patient sera, and vWF multimeric pattern were studied during episodes and again in remission in three groups of patients with severe forms of HUS and TTP paradigmatic of the most common clinical patterns of disease presentation: (1) plasma-responsive; (2) plasma-resistant; and (3) frequently relapsing. Plasma vWF:Ag and serum-induced vWF release from EC were increased in the acute phase of either plasma-responsive and plasma-resistant HUS and TTP, but normalized at remission only in plasma-responsive cases. Both indices were persistently normal in the relapsing forms. Enhanced vWF fragmentation as defined by disappearance of high molecular weight and increase in low molecular weight forms was a consistent finding of the acute phases, and always normalized in remission in all three groups. Unusually large vWF multimers were found exclusively in plasma of relapsing forms of HUS and TTP both during and between relapses. Enhanced levels of vWF:Ag and serum capability to induce vWF release in vitro are markers of disease activity and may reflect systemic endothelial injury and consequent activation. Their presence discriminates acute single-episode cases from relapsing forms and, when failing to normalize with plasma therapy, predicts plasma resistance. Enhanced low molecular weight multimers that closely paralleled disease activity suggest a permissive role of fragmented vWF in the formation of microvascular thrombi. Finally, finding of unusually large multimers exclusively in relapsing forms of HUS and TTP even between relapses, when no other clinical signs of disease activity could be detected, suggests that they cannot be the only factor in microvascular thrombosis.
Acute and Chronic Renal Effects of Recombinant Human TGF-β2 in the Rat
Authors: KELLY FRANCIS J. , ANDERSON SHARON , THOMPSON MICHELE M. , OYAMA TERRY T. , KENNEFICK THOMAS M. , CORLESS CHRISTOPHER L. , ROMAN RICHARD J. , KURTZBERG LESLIE , PRATT BRUCE M. , LEDBETTER STEVEN R.
Published: May 2021

The expression of transforming growth factor-β (TGF-β) correlates with the incidence of renal glomerular and interstitial injury, however, nothing is known of the effect of these proteins on renal hemodynamics. This study examines the renal hemodynamic and morphologic effects of recombinant human TGF-β2 in normal male Sprague Dawley rats. Acute infusion of TGF-β2 (1.2 μg/kg per min) induced no hemodynamic changes, except for a modest though significant fall in mean arterial pressure. Administering TGF-β2 at varying doses (20, 100, and 400 μg/kg) for 9 wk caused modest increases in systolic BP and proteinuria and minimal tubular interstitial fibrosis, however, renal hemodynamic end points were not significantly altered. TGF-β2 (800 μg/kg) was also administered to volume-depleted rats for 7 consecutive days. In contrast to the findings in volume-replete animals, administration of TGF-β2 to volume-depleted rats caused a marked reduction in GFR and medullary blood flow. Histologic fibrosis of the medullary vasa recta and cortical interstitium was seen, but glomeruli were unaffected. Thus, acute and short-term chronic TGF-β2 administration did not induce major renal changes in the volume-replete state, however, TGF-β2 combined with volume depletion caused medullary hypoperfusion and reduced GFR.
Prevalence, Predictors, and Consequences of Late Nephrology Referral at a Tertiary Care Center
Authors: ARORA PRADEEP , OBRADOR GREGORIO T. , RUTHAZER ROBIN , KAUSZ ANNAMARIA T. , MEYER KLEMENS B. , JENULESON CONSTANCE S. , PEREIRA BRIAN J. G.
Published: May 2021

Despite improvements in dialysis care, mortality of patients with end-stage renal disease (ESRD) remains high. One factor that has thus far received little attention, but might contribute to morbidity and mortality, is the timing of referral to the nephrologist. This study examines the hypothesis that late referral of patients to the nephrologist might lead to suboptimal pre-ESRD care. Clinical and laboratory data were obtained from the patient records and electronic databases of New England Medical Center, its affiliated dialysis unit (Dialysis Clinics, Inc., Boston), and the office records of the outpatient nephrology clinic. Early (ER) and late (LR) referral were defined by the time of first nephrology encounter greater than or less than 4 mo, respectively, before initiation of dialysis. Multivariate models were built to explore factors associated with LR, and whether LR is associated with hypoalbuminemia or late initiation of dialysis. Of the 135 patients, 30 (22%) were referred late. There were no differences in age, gender, race, and cause of ESRD between ER and LR patients. However, there were significant differences in insurance coverage between these two groups. In the multivariate analysis, patients covered by health maintenance organizations were more likely to be referred late (odds ratio = 4.5) than patients covered by Medicare. Compared to ER, LR patients were more likely to have hypoalbuminemia (56% versus 80%), hematocrit <28% (33% versus 55%), and predicted GFR <5 ml/min per 1.73 m2 (17% versus 40%) at the start of dialysis, and less likely to have received erythropoietin (40% versus 17%) or have a functioning permanent vascular access for the first hemodialysis (40% versus 4%). It is concluded that late referral to the nephrologist is common in the United States and is associated with poor pre-ESRD care. Pre-ESRD care of patients treated by nephrologists was also less than ideal. The patient-, physician-, and system-related factors behind this observation are unclear. Meanwhile, pre-ESRD educational efforts need to target patients, generalists, and nephrologists.
Effect of Intravenous Saline, Albumin, or Hydroxyethylstarch on Blood Volume during Combined Ultrafiltration and Hemodialysis
Authors: VAN DER SANDE FRANK M. , KOOMAN JEROEN P. , BARENDREGT JOS N. M. , NIEMAN FRED H. M. , LEUNISSEN KAREL M. L.
Published: May 2021

It is generally advocated to use saline or albumin infusions during symptomatic hypotension during dialysis. However, because of their side effects and/or costs, they are of limited use. Hydroxyethylstarch (HES), a synthetic colloid with a long-standing volume effect, is used in the management of hypovolemia. In this study, the efficacy of three fluids (isotonic saline [0.9%], albumin [20%], and HES [10%]) was assessed during three treatment sessions with combined ultrafiltration and hemodialysis, which differed in the type of fluid given intravenously. Changes in relative blood volume (BV), systolic BP (SBP), and vascular reactivity (venous tone [VT]) were compared. An intravenous infusion of 100 ml of fluid was given when the decrease in BV versus baseline was more than 10% as measured by a continuous optical reflection method. The ultrafiltration was continued. BV decreased significantly versus baseline independent of the intravenous fluid administration in all three treatment sessions. However, when we compared BV values at the end of the dialysis session with those at the time of infusion, BV continued to decrease significantly with saline (change in BV -4.56 ± 2.75%; P < 0.05) and albumin (change in BV - 2.13 ± 2.51%; P < 0.05), but not with HES (change in BV -0.15 ± 2.17%; NS). Between albumin and HES there were no significant differences in changes in BV (NS), whereas between HES and saline (P < 0.05) and between albumin and saline (P < 0.05) the differences in BV changes were significant. SBP remained unchanged within each session. Although SBP tended to decrease more with saline compared to albumin and HES, the difference was not significant. The higher decrease in BV and SBP with saline was counterbalanced by a significantly higher increase in VT, while VT remained unchanged in the other two sessions. It is concluded that HES is a promising fluid in preserving blood volume, comparable to albumin, but superior to saline.
Antihypertensive Medication and Renal Allograft Failure
Authors: SOROF JONATHAN M. , SULLIVAN E. KENNETH , TEJANI AMIR , PORTMAN RONALD J.
Published: May 2021

Hypertension after renal transplantation occurs commonly and, in adults, is associated with decreased graft survival. The North American Pediatric Renal Transplant Cooperative Study database was analyzed to determine: (1) the percent use of antihypertensive (anti-HTN) medication based on donor type, race, age, and acute rejection status; and (2) whether use of anti-HTN medication is associated with higher rates of subsequent graft failure. Data regarding anti-HTN medication use was available in 5251 renal allografts (4821 patients) with >30 d graft function. Posttransplant follow-up data were collected at 30 d, 6 mo, 12 mo, and then annually for 5 yr. At each follow-up, patients were selected for further analysis if the graft was functioning at that visit and subsequent follow-up data were available. Overall, anti-HTN medication use was 79% on day 30 and 58% at 5 yr. At each follow-up, anti-HTN medication use was higher (P < 0.01) for cadaveric donor versus living related donor, blacks versus whites, age >12 versus <12 yr, and ≥1 versus 0 acute rejection episodes. Anti-HTN medication use at each annual follow-up was associated with significantly higher rates of subsequent graft failure. Multiple regression analysis controlling for all factors associated with increased use of anti-HTN medications revealed a relative risk of graft failure for use of anti-HTN medication of greater than 1.4 (P < 0.001). In recipients of cadaveric allografts, only acute rejection status predicted subsequent graft failure more strongly than use of anti-HTN medications. These data suggest that hypertension after renal transplantation in children, as evidenced by use of anti-HTN medications, is associated with increased rates of subsequent graft failure.
Apolipoproteins Prevent Glomerular Albumin Permeability Induced In Vitro by Serum from Patients with Focal Segmental Glomerulosclerosis
Authors: CANDIANO GIOVANNI , MUSANTE LUCA , CARRARO MICHELE , FACCINI LUIGI , CAMPANACCI LUCIANO , ZENNARO CRISTINA , ARTERO MARY , GINEVRI FABRIZIO , PERFUMO FRANCESCO , GUSMANO ROSANNA , GHIGGERI GIAN MARCO
Published: May 2021

Glomerular albumin permeability alterations can be induced in vitro by serum from patients with end-stage renal disease caused by primary focal segmental glomerulosclerosis (FSGS). It was hypothesized that inhibitory substances may be present in normal serum, which may prevent the permeability alterations in isolated glomeruli, and the present study sought to isolate and characterize these factors. Albumin permeability was determined from the change in glomerular volume induced by applying oncotic gradients across the basement membrane of healthy isolated rat glomeruli preincubated with FSGS serum and normal serum fractionated using standard techniques. Fractions of normal serum with inhibitory activity obtained by a multistep chromatographic procedure underwent two-dimensional electrophoresis and staining. Approximately 50 protein spots were recovered, renatured, and tested for antipermeability activity. Five of these proteins demonstrated consistent inhibitory activity, and desorption ionization and mass spectrometry proved them to be components of high-density lipoprotein: apolipoproteins (apo) E2 and E4, high-molecular-weight J and L, and a 28-kD fragment of A-IV. Polyclonal antibodies to apo E or apo J added to the whole normal serum restored the permeability activity of the FSGS serum in the bioassay. Commercially available apo E and apo J also demonstrated antipermeability activity when added to FSGS serum. Cyanogen bromide digestion of apo A-IV produced fragments that inhibited the permeability activity of the FSGS serum, whereas the intact protein did not. Thus, components of high-density lipoprotein are capable of preventing glomerular albumin permeability induced by serum from patients with FSGS in an in vitro system. The specificity and mechanism of the inhibition remain to be determined; the alteration of normal inhibitory activity in vivo may be a component in the pathophysiology of FSGS.
Optimization of the Green Synthesis of Silver Nanoparticle with Box-Behnken Design: Using Aloe Vera Plant Extract as a Reduction Agent
Authors: GÖKŞEN Nazan , KAPLAN Özlem
Published: May 2021

Nowadays, many of plants are used as a reduction agent in biosynthesis of silver nanoparticles. In this study, green synthesis of silver nanoparticles was aimed to optimize with Box-Behnken design. Aloe vera plant extract was utilized as a reduction agent as it is the famous natural product in field of cosmetic and skin health care. The synthesized silver nanoparticles using Aloe vera plant extract solution were optimized by Box-Behnken design due to the influence of different factors such as microwave power, time, AgNO3 concentration, and ratio of volume of Aloe vera plant extract solution to volume of AgNO3 and the percentage yield of particle formation as a response. Quadratic polynomial model was used to carry out mathematical modelling and response surface analysis was performed to determine the independent variable-response relationship. The optimized silver nanoparticles were characterized using instrumental devices like FTIR spectroscopy UV-VIS spectrophotometry. In addition, the optimized silver nanoparticles were tested for antibacterial activity on Gram positive (S. aureus, E. faecalis) and Gram negative ( P. aeruginosa, K. pneumoniae )bacteria. Briefly, the trials interpreted successful synthesis of the silver nanoparticles along with comprehension of the related factors affecting their quality characteristics and remarkably developed antibacterial activity as helpful impact.
Experimental 70% Hepatectomy Model: Apoptotic Index, Proliferative Index and Mitotic Index
Authors: İRKİN Latife Ceyda , ÖZTÜRK Şamil
Published: May 2021

Liver regeneration is known to begin after experimentally induced liver resection. At first 24-48 hours, DNA synthesis reaches the maximum level after resection and significantly regeneration known to occur on the first 10 days. In this study, we was examined the regeneration of liver on the 1st and 14th days after the resection.

In experiment 21 Wistar albino male rats were used. The rats were randomly divided into three groups. All experimentally groups realized midline incision with laparotomy for resection of liver. Pedicles of the left lateral and median lobes of the liver were applied 70% hepatectomy by 4/0 silk binding. At the end of 1st and 14th days, liver tissue removed for light misroscobic analysis.

The tissue of all experimentally groups were showed some histopatological changes such as sinuzoidal dilatation, vacuolization in the hepatocytes. This histopatological findings were seem to increase at II. grup more than experimentally groups.

Mitotic index, apoptotic index and proliferation index of values at II. group was reached the maximum level. Other group (III) dramatically reduced the value of these index and were seem to reach near to values of the control group. Relative liver weight that determined each of experimentally groups were statistically significant differences compared to the control group.
About some changes in the intraorbital part of the optic nerve after a single injury. (On the question of de-and regeneration of nerves)
Authors: Pozharsky I. F.
Published: May 2021

The present study concerns the area, which occupied the researchers only in passing when solving various problems about the pathological morphology of the eye.
The significance of the nervous system in the life of the organism in connection with the structure of it
Authors: Favorsky A. V.
Published: May 2021

Even at the end of the past century, leading clinicians expressed themselves as follows: it's time to think anatomically in the clinic Lepine said; in the clinic, henceforth, it is necessary to think and act physiologically, added Huchard to this.
Dr. Anglade et Jacken. Cardiovascular form of epilepsy. Annales medicopsychologiques, 1908
Authors: Kovalevsky P. I.
Published: May 2021

Many authors recognize a special form of cardiovascular epilepsy.
Dr. Perugia. About the epileptic aura. La Reforma medica. 1908
Authors: Kovalevsky P. I.
Published: May 2021

Epileptic aura occurs in less than half of cases of epilepsy.
Dr. Ch. de Montet und dr. W. Skop. Myasthenia gravis und Muskelatrophie. Monatsschrift f. Psychiatrie und Neurologie 7. 1908
Authors: Sholomovich A.
Published: May 2021

A case of myasthenia with a pronounced atrophy of all muscles and a pronounced myasthenic reaction is described.
Dr Kurt Mendel. Trauma in the ethiology of nervous diseases. Der Unfall in der Aetiologie der Nervenkrankheiten. — Monatsschrift für Psychiatrie und Neurologie. September 1907-June 1908
Authors: Sholomovich A.
Published: May 2021

The voluminous work published in 10 books of the journal on the role of trauma in nervous pathologies is based on a thorough critical study of a huge number of cases of all kinds of forms of nervous diseases.
Jenö Kollarits. Bloody vomiting in gastric crises in tabets. Blutbrechen bei Crises gastriques tabétiques. Neurologisches Centralblatt No. I, 1909
Authors: Nakhsidov G.
Published: May 2021

K. cites a case of a 38 yr. Tabet, who, three months before admission to the clinic, suddenly began to appear, regardless of the intake of food, severe pain in the stomach area, followed by mucous vomiting of a greenish color.
V.N. Vasiliev. Foreigners from the north of the Turukhansk region. Yearbook of the Russian Anthropological Society at St. Petersburg University, 1908
Authors: Kovalevsky P. I.
Published: May 2021

The indisputable truth is that we, Russians, know a lot and at all do not know only our homeland.
H. Meige. Fear of trembling. Trémophobie. Revue neurol. 1909, No. I
Authors: Osokin N.
Published: May 2021

The obsessive state described by the name "tremophobia" is in many ways similar to erythrophobia.
Prof. Friedenreich. About mindfulness. (Criminal value of suspicion) Ueber Zurechnungsfähigkeit (In strafretlicher Bedeutung). Monatsschr. f. Psych. und Nervenheilk. 7-1908
Authors: Sholomovich A.
Published: May 2021

The author disagrees with the opinion that the issues of suspicion and invisibility - as a purely metaphysical understanding, should be resolved by lawyers, not doctors. Only psychiatr, according to the Copennagen scholar, can be a judge in these questions.
Jogos Cooperativos e Argumentação: Caminhos para uma Formação Crítica e Reflexiva de Licenciandos em Matemática
Authors: Lopes Carlos Antonio da Silva , De Chiaro Sylvia
Published: May 2021

ResumoO presente artigo se propõe a analisar o impacto de um curso de extensão sobre as relações entre jogos cooperativos e argumentação para uma prática crítica e reflexiva de licenciandos de Matemática de uma Universidade Federal de ensino superior. Para cada momento do curso foram desenvolvidas atividades que permitiram que os 05 licenciandos participantes tivessem contato tanto com os pressupostos teóricos sobre os jogos cooperativos e argumentação, como também vivenciassem atividades práticas que os mobilizaram na utilização dos conhecimentos adquiridos para a construção de um jogo cooperativo-argumentativo como produto final. Ao analisar os dados pudemos concluir que os licenciandos conseguiram desenvolver suas potencialidades cooperativas e argumentativas e foram capazes de elaborar um jogo que denotou a capacidade dos mesmos de pensar em como fazer emergir e manter a argumentação em um contexto cooperativo. Assim, além do curso de extensão ter contribuído para a formação crítica e reflexiva dos licenciandos envolvidos, a experiência formativa pela qual passaram ajudou-os na promoção de situações potencializadoras de um aprendizado igualmente crítico e reflexivo em suas salas de aula.

Palavras-chave: Argumentação. Jogos Cooperativos. Pensamento Crítico-Reflexivo. Formação Docente. Educação Matemática.

AbstractThis article aims to analyze the impact of an extension course about the relationship between cooperative games and argumentation, in order to offer critical and reflective practice to teaching students in Mathematics from a Federal University. For each phase of the course, activities were developed that allowed the 05 participating undergraduates to both have contact with the theoretical assumptions about cooperative games and argumentation, as well as experience practical activities that mobilized them in the use of the acquired knowledge to build a cooperative-argumentative game as a final product. By analyzing the data, we concluded that the undergraduates were able to develop their cooperative and argumentative potential and were capable of developing a game that showed their ability to think about how to make the argumentation emerge and be maintained in a cooperative context. Thus, in addition to the extension course having contributed to the critical and reflective training of the undergraduates involved, the formative experience they went through helped them to promote situations that equally enhanced critical and reflective learning in their classrooms.

Keywords: Argumentation. Cooperative Games. Reflexive-Critical Thinking. Teacher Training. Mathematics Education.
O papel das Funções Cognitivas em Praxeologias de Tipos de Tarefas Matemáticas
Authors: Fonseca Laerte Silva da , Carvalho Edmo Fernandes , Silva Luciano Pontes da , Silva Kleyfton Soares da
Published: May 2021

ResumoO objetivo principal deste trabalho é descrever uma análise sobre como as funções cognitivas atuam diretamente em organizações praxeológicas relativas a tipos de tarefas trigonométricas, relevando a complexidade neurocognitiva para realização das mesmas. A metodologia considerou uma pesquisa bibliográfica, ressaltando-se a importância de aproximar elementos da Teoria Antropológica do Didático (TAD) e da Neurociência Cognitiva. Foi verificado que para a realização de tipos de tarefas matemáticas, no campo da Trigonometria, cuja organização praxeológica esteja bem definida é possível atribuí-las aos estudantes como um convite ao desafio e, de forma gradativa, respeitando-se as condições da neurofisiologia do cérebro. Desse modo, possíveis dificuldades de estudantes frente um determinado saber matemático, pode ser atribuído ao tipo de tarefa proposta. O estudo de algumas funções cognitivas corrobora de certo modo com o estudo dessas dificuldades. Permite inclusive, compreender as implicações da falta de sentido das matemáticas escolares na vida do sujeito. Outro ponto importante a ser destacado remete à necessidade dos cursos de formação de professores de matemática oportunizar aos licenciandos conhecimentos de neurociência cognitiva, pois quanto mais se sabe sobre o funcionamento do cérebro, melhor será a escolha dos tipos de tarefas matemáticas para apresentá-las tanto nas salas de aulas, como nos livros didáticos.
Palavras-chave: Funções Cognitivas. Praxelogias. Tipos de Tarefas Matemáticas.
AbstractThe main objective of this work is to describe an analysis of how cognitive functions act directly in praxeological organizations related to types of trigonometric tasks, emphasizing the neurocognitive complexity to perform them. The methodology considered a bibliographical research, highlighting the importance of approaching elements of the Didactic Anthropological Theory and Cognitive Neuroscience. It was verified that for the accomplishment of types of mathematical tasks, in the field of Trigonometry, whose praxeological organization is well defined, it is possible to attribute them to the students as an invitation to the challenge and, in a gradual way, respecting the conditions of the neurophysiology of the brain. Thus, possible difficulties of students in the face of certain mathematical knowledge, can be attributed to the type of task proposed. The study of some cognitive functions corroborates in a way with the study of these difficulties. It even allows us to understand the implications of the lack of meaning of school mathematics in people's lives. Another important point to be highlighted is the need for training courses for mathematics teachers to give graduates the knowledge of cognitive neuroscience, since the more we know about brain functioning, the better the choice of the types of mathematical tasks to present them in classrooms, as in textbooks.
Keywords: Cognitive Functions. Praxeologies. Types of Math Tasks.
Fatty Acid Composition in Yersinia ruckeri Strains Isolated from Rainbow Trout Farms
Authors: İSPİR Ünal , ÖZCAN Mikail , KIRICI Muammer
Published: May 2021

In this study, a total of 33 Yersinia ruckeri isolates were obtained from rainbow trout farms in the five different region of Turkey. We were determined to changes in fatty acids group of the strains. All the isolates were identified as Y. ruckeri based on colonical, cellular morphology and biochemical characters. All Y. ruckeri 11 major fatty acids, including 12:0 (Laurik acid), 14:0 (Miristik acid), 16:0 (Palmitik acid), 16:1n-7 (Palmitoleik acid), 17:1 (Heptadekanoik acid), 18:1n-9c (Oleik acid), 18:2n-6c (Linoleik acid), 18:3n-3c (Alfa-linoleik acid), 22:0 (Behenik acid), 22:1 (Dokosenoik acid) and 24:1 (Tetrakosenoik acid). Compared to isolates biochemical property. There was no different between fatty acids and biochemical characteristics. The results of this study show that the fatty acids composition of Y. ruckeri isolated strains from rainbow trout farms in Turkey is on a large scale homogenous.
INVESTIGATION OF ACADEMIC SELF-EFFICACY ACCORDING TO PERCEPTIONS OF SPORTS HIGH SCHOOL STUDENTS
Authors: Bingölbalı Abdullah , Karakaya Yunus Emre
Published: May 2021

This study aims to investigate academic self-efficacy according to the perceptions of students who studied in sports high schools. The study covered a sample of 538 students, who were randomly chosen and studied in Elazığ Sports High School, Malatya Sports High School, and Mardin Sports High School. The data were collected from the sample of the study by using the “Academic Self-Efficacy Scale”. The data were analyzed by using the licensed SPSS 22.0 package software. As a result of the investigations, no differences were observed in terms of the variables of gender, grade level of education, father’s education level, mother’s education level, and family’s monthly income level (p>0.05). In the education period, statistically significant differences were determined according to the variable of the place of residence (p
AKILLI KENT UYGULAMALARINDA KİŞİSEL VERİLERİN GİZLİLİĞİ VE GÜVENLİĞİ
Authors: Hayta Yasemin
Published: May 2021

Kentler bireyler ve küresel medeniyet arasında etkileşimi sağlayan canlı organizmalardır. İnsanoğlunun medeniyet ilerleyişi içerisinde kurduğu mahallelerden büyük kentlere uzanan yolculuğu birçok faktörün etkisi ile şekillenmektedir. Kent yaşamı ilkel anlamda güvenlik ve sağlık gibi en temel ihtiyaçlar çerçevesinde gerçekleşmiş olsa da günümüz çağı için çok daha karmaşık sorunlarla karşılaşmakta ve çözümler aramaktadır. Zira artık güvenlik kavramı can ve mal için değil dijital veriler, siber saldırılar gibi yeni ve ciddi sorunları da ifade edecek şekilde genişlemiştir. Akıllı kentler dijital bağlantı yoluyla kitlelere daha yüksek bir yaşam kalitesi getirecek ve kentlerde verimlilik ve erişilebilirliğe yol açacaktır. Akıllı şehirler, vatandaşlarının katılımını sağlamak için bireysel mahremiyet ve güvenliği de sağlamalıdır. Vatandaşlar katılmaya isteksizse, akıllı bir şehrin temel avantajları ortadan kalkacaktır. 21.yüzyıl kent yaşamını anlamak için güncel sorunları ve bu sorunlara çözüm üretmek amacıyla kullanılan akıllı kent uygulamaları, bu uygulamaların malzemesi olan veri, büyük veri, açık veri ve nihayetinde akıllı kent uygulamalarında kullanılan kişisel verilerin gizliliği ve güvenliği kavramlarını anlamak gereklidir. Bu makalede akıllı kent uygulamalarının hangi tür veriyi kullandığı ve bu verilerin 6698 sayılı Kişisel Verilerin Korunması Kanun’un çizdiği sınırlar referans alınarak; kişisel verilerin ihlal edilme durumunun değerlendirilmesi yapılmaktadır.
Status of training a bachelor degree in hospital social work at the Hanoi University of Public Health: Some recommendations
Authors: Pham Tien Nam
Published: May 2021

Training a bachelor degree in hospital social work plays an important role in improving the quality of human resources on social work in the health sector. The objective of the study was to describe the status of training a bachelor degree in hospital social work at the Hanoi University of Public Health and to give a number of recommendations. This was a cross-sectional study, through collection of secondary data and qualitative research (09 in-depth interviews, 03 focus group discussions). The research results showed that the outcome standards and curriculum framework are logical and appropriate, clearly showing the training program of hospital social work. Faculty members have appropriate professional qualifications, diversified teaching methods, enthusiasm, fairness and equality with learners. The network of social work practice\internships is diversified in large-scale hospitals. The hospital social work materials\textbooks have been compiled for instruction in the training program. The study also pointed out some difficulties in the status of training a bachelor degree in hospital social work at the Hanoi University of Public Health and proposed some recommendations to improve the quality of the training program in the future.
Factors affecting agricultural students’ loyalty: a study at Nong Lam University Ho Chi Minh City
Authors: Vo Van Viet , Le Anh Thu
Published: May 2021

This study was conducted with the objective of identifying the influence of service quality, university image on agricultural students’ satisfaction and loyalty. The quantitative research approach was applied. Data were collected using questionnaires with a sample size of 313 students who majored in Veterinary Medicine, Animal Husbandry, Agronomy and Plant Protection at Nong Lam University Ho Chi Minh City. The sample has been selected by convenient method. The research results show that agricultural students’ satisfactions and loyalty are affected by service quality and school image. In which, the school image has the stronger impact on student satisfaction and loyalty. From the findings, the researcher has made conclusions and some suggestions to contribute to improving student loyalty.
Practices and solutions to improve profressional quality for preschool teachers in the organization of music education activities
Authors: Le Thu Trang
Published: May 2021

Teachers are one of the most important factorsin determining the quality of education. In the context of education innovation in recent years improve profressional capacity, major of general teacher and preschool teachers in particular are increasingly interested. In the article, author mentions situation of music education activities program at kindergartens and suggests some solutions to improve quality of music education to foster profressional capacity building bring to preschool education high quality human resources, meeting the requirements of education reform in the current period.
Creating a frame for assessment of ICT competence of students in High schools
Authors: Kieu Phuong Thuy , Nguyen Chi Trung , Ho Cam Ha
Published: May 2021

Self-directed learning is one of the important competencies for lifelong learning. A person with self-directed learning will be able to adapt and develop in modern society where knowledge and skills of a that person for living and working are constantly increasing and changing. Self-directed learning competence is defined as one of the core common competencies of students in the General Education Curriculumn 2018. This paper summarizes typical studies in Vietnam and in the world about self-directed learning, focusing on clarifying the viewpoint of self-directed learning and the manifestations of self-directed learning competence. Based on the researched points of view, the paper proposes a framework for assessing the self-directed learning competence of high school students. This framework has an important role to play in measuring the effectiveness of measures to develop students' selfdirected learning competence.
legados de la guerra de Independencia y la Revolución sobre la violencia criminal en México
Authors: Arias Luz Marina , De la Calle Robles Luis Miguel
Published: May 2021

Este trabajo se enfoca en las conexiones históricas de la violencia criminal contemporánea en México. Investiga si la guerra de independencia y la revolución muestran alguna línea de continuidad con la actual oleada de violencia criminal. Encontramos que la violencia criminal se concentra principalmente en municipios que tuvieron presencia rebelde durante el periodo revolucionario. Además, los municipios en los que se crearon milicias realistas durante la guerra de independencia muestran una menor violencia criminal hoy en día. El legado de la violencia parece transitar a través de dos caminos causales. Los municipios hoy más violentos son aquellos que contaban con una menor presencia de instituciones indígenas durante el virreinato (los llamados pueblos de indios). Además, los municipios con más capacidades estatales locales a finales del siglo XIX tienen menos violencia hoy. Por el contrario, las varias reformas de la tierra del periodo autoritario no parecen reducir la violencia criminal.
Hachar un roble. Vascos y muerte en el Tandil decimonónico, Argentina
Authors: Irianni Zalacain Marcelino
Published: May 2021

El 1 de enero de 1872, medio centenar de nativos asesinó a una treintena de extranjeros en Tandil (provincia de Buenos Aires). La matanza se llevó a cabo en apenas cuatro horas. El Sumario judicial deja al descubierto un episodio compulsivo en la conformación del grupo agresor, selectivo en cuanto a la etnia que más víctimas sufre y motivado desde ideas economicistas, sociales y hasta religiosas. Se trata de un ataque difusamente xenófobo, temprano, más bien rural y enfocado en carreteros y comerciantes vascos.
Revenue Statistics in Latin America and the Caribbean 2021
Authors:   Inter American Development Bank,   Organization for Economic Cooperation and Development,   Economic Commission for Latin America and the Caribbean,   Inter American Center of Tax Administrations
Published: May 2021

This report compiles comparable tax revenue statistics over the period 1990-2019 for 27 Latin American and Caribbean economies. Based on the OECD Revenue Statistics database, it applies the OECD methodology to countries in Latin America and the Caribbean to enable comparison of tax levels and tax structures on a consistent basis, both among the economies of the region and with other economies. This publication is jointly undertaken by the OECD Centre for Tax Policy and Administration, the OECD Development Centre, the Inter-American Center of Tax Administrations (CIAT), the Economic Commission for Latin America and the Caribbean (ECLAC) and the Inter-American Development Bank (IDB). The 2021 edition is produced with the support of the EU Regional Facility for Development in Transition for Latin America and the Caribbean, which results from joint work led by the European Union, the OECD and its Development Centre, and ECLAC.
Opłata za egzamin wstępny na aplikację adwokacką oraz za egzamin adwokacki jako źródło dochodu budżetu państwa
Authors: Bożek Wojciech
Published: May 2021

W opracowaniu dokonano analizy podstaw prawnych obowiązku opłatowoprawnego za egzamin wstępny na aplikacje adwokacka oraz egzamin adwokacki, a nadto, omówiono podstawowe funkcje tych opłat z odniesieniem do poglądów wyrażonych w literaturze przedmiotu. Autor opracowania w formie tabelarycznej i wykresów podjął próbę zobrazowania rzeczywistej wysokości dochodów budżetu państwa z tytułu opłat uiszczonych przez osoby, które przystąpiły do egzaminu wstępnego na aplikacje adwokacka i do egzaminu adwokackiego w latach 2009–2013/2014. W opracowaniu przeprowadzono analizę stanu prawnego obowiązującego w dniu 4 lipca 2014 r.
Altmanʼs Model as an Instrument for the Evaluation of the Financial Situation of the Alma Market S.A.
Authors: Lewandowska Justyna , Jakubczyk Beata
Published: May 2021

This article is the result of empirical research on the use of Altmanʼs model in assessing the financial position of companies. The aim of the study was to try to see the situation of the company Alma Market S.A. for symptoms suggestive of business failure. For a thorough analysis of the discriminative model was used. The calculated value of the function enabled the assessment of the condition of the body by classifying it into the group is not threatened by insolvency.
The Impact of Dividends’ Policy on the Cost of Equity of Enea S.A.
Authors: Wrycol Anna
Published: May 2021

The article is an attempt to depict the procedures and regulations accompanying the policy of dividends in a company with a particular emphasis which is put on Enea S.A. The purpose of the empirical part is to analyze and assess the effectiveness of applying discounted dividends model to calculate the cost of equity for the company. It juxtaposes advantages and impediments in using the model, as well as infers if Gordon model is adequate in estimating the cost of equity for the presented company.
Zakup obligacji banków spółdzielczych poprzez Indywidualne Konto Emerytalne jako forma zabezpieczenia emerytalnego
Authors: Zdradzisz Wojciech
Published: May 2021

Celem tego artykułu jest zbadanie realnego oprocentowania obligacji banków spółdzielczych zakupionych poprzez Indywidualne Konto Emerytalne. Przedstawiono również obowiązujący system emerytalny, w tym możliwość uniknięcia płacenia podatku dochodowego w ramach konta IKE. Pokazano także sytuację rynkową dotycząca stóp procentowych, inflacji i ceny pieniądza na rynku międzybankowym za ostatnie 10 lat, a ponadto opisano instrumenty finansowe jakimi są obligacje banków spółdzielczych.
Dodatek kwartalny
Authors: Uryszek Tomasz , Zimny Artur , Witczak Radosław , Gądek Artur , Kot Kornel , Kuchciak Iwa , Ślebocka Magdalena , Tylman Aneta
Published: May 2021

„Zadłużenie publiczne w 2014 roku”

„Koniunktura w sektorze przedsiębiorstw niefinansowych w 4. kwartale 2014 r.”

„Koniunktura giełdowa”

„Zmiany w świecie finansów (podatków)”

„Sytuacja gospodarcza w Polsce po pierwszym kwartale 2015 r.”

„Polski sektor bankowy wobec wzrostu ryzyka walutowego”

„Rewitalizacja miast polskich – zagadnienia wstępne. Projekt Wytycznych w zakresie finansowania rewitalizacji w programach operacyjnych na lata 2014–2020”
Avaliação do comportamento em campo de solo reforçado com fibras de PET para bases de radier
Authors: De Freitas João , Polastri Paula , De Angelis Neto Generoso , Belincanta Antonio , Hemetério Cordeiro dos Reis Jeselay
Published: May 2021

Atualmente, o uso de radier em edificações de pequeno porte tem se intensificado, no entanto, essa alternativa não pode ser usada em solos de baixa capacidade de carga. Uma alternativa é a de se promover uma melhoria ou reforço da camada de base. Para tanto, este trabalho faz-se uma avaliação do comportamento mecânico de um solo arenoso fino reforçado com fibras de tereftalato (PET) para uso como base de radier. Foram usados modelos de reforço executados em campo com camadas de 300 mm de espessura de solo compactado nas condições ótimas de compactação reforçado com 1 % de fibras de PET.Â  Avaliação do desempenho foi feita usando ensaios de provas de carga estática em placa circular de 340 mm de diâmetro. Foram realizados ensaios em três condições: solo reforçado com fibra, Solo compactado sem reforço e no solo natural. Os resultados mostraram que a adição de fibra melhora a capacidade de carga, aumenta a rigidez, diminuindo os deslocamentos para as cargas de serviço, sendo que a superfície de ruptura mobiliza uma maior região. Conclui-se que a adição de fibra melhora o desempenho da camada de base, apresentando ganho de capacidade de carga, no entanto, esse ganho ocorre para grandes deslocamentos.
Padres de familia en la gestión educativa de escuelas rurales
Authors: Medina-Arévalo Adriana Del Pilar , Estupiñán-Aponte María Rosa
Published: May 2021

Como proceso permanente de cualificación de la educación, la gestión educativa aborda diferentes aspectos de la vida cotidiana de un establecimiento educativo; por lo que requiere de la contribución de todos los actores que la conforman. El artículo pretende reflexionar sobre el rol de padres de familia como agentes de la gestión educativa en instituciones escolares rurales de Colombia, buscando promover miradas alternativas que reconozcan su contribución al mejoramiento de la calidad de la educación y al desarrollo de las comunidades de influencia. Para ello se analizaron documentos indexados en Google Académico, Dialnet, Redalyc, Latindex, Scielo, mediante los buscadores: educación rural, relación padres escuela, participación de padres, gestión educativa. Teniendo en cuenta las dificultades que enfrentan las instituciones en contextos de ruralidad, los padres de familia podrían desempeñar un papel muy valioso para la consolidación de acciones que contribuyan al mejoramiento en la calidad de los procesos educativos. En el país el Ministerio de Educación Nacional propone a las Instituciones gestionar sus procesos de mejoramiento articulando a los miembros de la Comunidad Educativa, otorgándoles el rol de agentes en el proceso, dado que, al vincularse, contribuyen en la movilización de acciones promovidas por los centros educativos. No obstante, la investigación sobre gestión educativa en estos contextos permite establecer que la educación rural está siendo estudiada desde sus privaciones y se ha enfocado en directivos y docentes donde los padres de familia son vistos como agentes externos y con muy escasa participación en las diversas actividades que se gestan al interior de los establecimientos. De esta forma, tanto la familia como la escuela siguen representando los ejes de socialización de niños y niñas que deben ser resignificados desde las condiciones actuales que caracterizan los contextos rurales, para lograr procesos educativos más coherentes y pertinentes a las necesidades de las comunidades campesinas.
A vigência do capital
Authors: Alves Giovanni A. P.
Published: May 2021

O artigo busca articular alguns pontos de reflexão sobre as transformações econômicas e sociais do capitalismo tardio em crise e seus impactos sobre o pensamento social contemporâneo.
OSTEOCHONDROMA FRACTURE IN YOUNG ATHLETE: A CASE REPORT
Authors: Irsyam Ilham Abdullah , Andriandi Andriandi , Meliala Nehemia
Published: May 2021

Background: Osteochondroma is a benign bone tumor that most cases are asymptomatic. The symptoms may occur as a complication of osteochondroma, which is rarely happened. Surgical intervention is needed to treat the complications.Case:  A 20-year old male football athlete presented with pain on his left thigh's lump after he fell during his training. Mass and tenderness on the medial side of the left distal femur were found. Plain X-Ray showed an irregular mass on the left distal femur's surface with a fracture through the stalk of pedunculated osteochondroma. The patient underwent total excision of the osteochondroma.Discussion: The fracture of the osteochondroma often occurs in teenagers because they are more active physically. It happens due to direct or indirect injury. The treatment of this fracture is controversial between observation or surgical excision. In this case report, the patient could demonstrate full weight-bearing right after the surgery.Conclusion: Fracture as a complication in osteochondroma often happens to teenagers, and surgery proved to give a good outcome in this case.
Russian Modernization: Institutional Traps and Civilization Landmarks
Authors: Gontmakher E.
Published: May 2021

Modernization is not just a sum of concrete material projects, nor can it be limited by technological projects. Democracy and market economy are indispensible for creating a modern society in Russia. European values cannot be ignored. At the same time, it is impossible to forget that an intense conflict is going on along the line North-South, exacerbated lately by the rise of terrorism.
Russian Economic and Geopolitical Schools
Authors: Gloveli G.
Published: May 2021

Two outstanding scientists of the late 19th – early 20th century V.P. Semenov-Tyan'-Shan'skii, a successor to encyclopedic traditions, and P.N. Savitskii, a promoter of the Eurasian movement, can be justly entitled the founders of the Russian economic-geopolitical school. Their generalizations are interesting not only for the history of geopolitical doctrines, but also for modern geoeconomics and a comparative historical-economical study methodology. In the article, the main Russia's development concepts formulated and introduced by the above mentioned scientists are investigated, also their predecessors' works both here and abroad are examined.
World Economy Development: Environmental Concern
Authors: Piskulova N.
Published: May 2021

Many scientists note that at the present stage, the environmental concern becomes an economic growth restrictor, and raises an issue of another development model working-out. What kind of model it is, what its core is, will Russia be able to fit in with it – these are the main questions that the present article is trying to answer.