bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Bronchial Asthma Education Program on Asthma Control among Asthma Patients
Authors: Jagadeeswari J  , Rangila R
Published: October 2020

Asthma attacks all age gatherings however it regularly begins in childhood age itself. It is a sickness depicted by irregular attacks of shortness of breath and wheezing, which move in earnestness and repeat from individual to person. In an attacks, the coating of the entries swell making the aviation routes limited and decreasing the progression of air all through the lungs. In an individual, this may happen from hour to hour and everyday too. The incidence is 5% in adult population and 10% in children. Incidence of asthma has considerably increased over last few decades so the present study aims to assess the effectiveness of Bronchial Asthma Education Program on Asthma control among Asthma Patients. A quantitative approach with Pre-Experimental research design was adopted to conduct the study among 30 Bronchial Asthma patients who were selected by Non- probability convenience sampling technique. Semi-structured interview method was used to collect the demographic data and level of knowledge regarding asthma among asthma patients was assessed by structured questionnaire. The Bronchial Asthma education was given with flash card which includes the details which controls Asthma. The results of the study shows that among 30 samples in the experimental group the pretest results reveal, 25(83.34%) had inadequate knowledge, 4(13.33%) had moderately adequate knowledge and 1(3.33%) had good knowledge.Where as in the post test, 20(66.67%) had adequate knowledge and 10(33.33%) had moderately adequate knowledge regarding Bronchial Asthma among asthma patients. This reveals the level of knowledge regarding asthma is highly significant in the experimental group because the level of knowledge is improved after health education.
Design, Optimization and Evaluation of Snedds Based System for Orlistat: A Quality by Design Approach With 23 Factorial
Authors: Amisha Vyas  , Anupama Diwan  , Rupali Sharma
Published: October 2020

Obesity, as defined by WHO is an abnormal or excessive fat accumulation that may impair health. is directly proportional to the resultant impact of genetic, metabolic, environment, and culture issues. The leading cause of obesity is an energy imbalance between calories consumed and calories exhausted. To design and optimize SNEDDS formulation by the development of SNEDDS with an appropriate quantity of oil, and with the factorial approach. A series of SNEDDS formulations for was prepared based on solubility studies, pseudo ternary phase diagram and visual observation. was added inaccurately weighed amount of oil into a screw-capped glass vial and heated in a water bath at 40ºC. The and were added to the oily mixture and stirred with a magnetic bar. The formulation was further for 15 minutes and stored at room temperature. From the result of evaluation parameters such as emulsification time 6±1s, % transmittance 94.01±1.5%, drug Loading 99.89%±0.56%, Index 0.47±0.01 and 0.211±0.02, Globulesize99±6 nm, Zeta potential -28.12 and -24.5 , The , Freeze-thaw cycle, Heating-cooling cycle showed no signs of phase separation, Viscosity 132.4±0m Pa.s, drug release 99.25% within 90 minutes, drug release follows Korsmeyer-Peppas model mechanism, n value was found to be1.083 hence it can be postulated formulation F-6 followed the or anomalous release and P-value for factors emulsification time, % transmittance and % drug release was found less than 0.0500 and hence it was concluded formulation F-6 an optimized formulation.
Effect of ethanolic extract of cashew leaf ( Anacardium occidentale L ) on edema, hyperalgesia and malondialdehyde levels of the rat foot of an inৎlammatory model compared to diclofenac
Authors: Dwintha Lestari  , Indrati  , Anggun Rafisa
Published: October 2020

Inflammation is a body tissue reaction to the damage caused by foreign object. One of the plants that the community uses to eliminate inflammation is cashew leaf (Anacardium occidentale L). This research aimed to find out if the guava extract has an anti-inflammatory effects compared with diclofenac. This was an experimental study using 30-tails Wistar strain, which is divided into 6 groups that every 1 hour later induced lambda-carrageenan. Group I and IV are given ethanolic extract of cashew leaf 300 mg/kg BW. Group II and V were given cellulose (CMC) 1% as a control. Group III and VI were given diclofenac 4.5 mg/kg of BW. Edema volume from hour 1 to 6 and MDA levels of foot tissue in the hour 6 were measured in group I, II, III. Hyperalgesia was measured in group IV, V and VI. All research results were statistically tested with ANOVA test followed by the Newman Keuls test. Ethanolic extract of cashew leaf 300 mg/kg BW inhibited the formation of edema volume, preventing hyperalgesia significantly (P < 0.05) compared to a group of control and diclofenac. Measurement of MDA levels between groups with ethanolic extract of cashew leaf, control, and diclofenac was not significantly different (P > 0.05). Ethanolic extract of cashew leaf has an anti-inflammatory effect based on inhibition of edema volume, hyperalgesia.
Approach Towards Kushta (Psoriasis) With Ayurveda - A Case Study
Authors: Sourabh G Deshmukh  , Trupti I. Thakre
Published: October 2020

Psoriasis is an autoimmune papulo-squamous disorder of the skin, characterized by sharply defined erythemato- squamous lesions covered with silvery scaling. It is chronic and is well known for its course of remissions and exacerbations. The worldwide burden of psoriasis is 2%, and the prevalence of psoriasis in India ranges from 0.44% to 2.8%. There is no radical cure for psoriasis due to its autoimmune nature. It can be correlated with Eka Kushtha, one of the types of Kshudra Kushtha. In Ayurveda, Vamana and Virechan karma are indicated in Kushtha, which results in the elimination of vitiated Doshas. The effect of Shodhana Chikitsa can be increased if it is followed by shaman Chikitsa which include both Antaparimarjan and Bahiparimarjan Chikitsa. So here a 41 years old female patient had complaints of whitish silvery plaques, itching, burning sensation and scaling since one year was successfully treated with Vamana and Virechan Karma, followed by Shamana Chikitsa like Gandhaka Rasayana, Vetapalli oil, S-kin powder, Padachira ointment for external application and Avipattikar Churna- 3gm twice a day before food with water for 15 days. Conclusion: The Vamana Karma and Virechan followed by Shamana Chikitsa orally, and local application is highly effective in patients of Eka Kushtha (Chronic Plaque Psoriasis).
The prevalence of risk for Obstructive Sleep Apnea among type 2 diabetes mellitus patients
Authors: MuddalaVaraPrasanna Rao  , Vijay Kumar G  , Chetlur Haripriya
Published: October 2020

Obstructive sleep apnea (OSA) is a common medical disorder and Type 2 Diabetes mellitus (T2DM) is an endocrine disorder where both of them commonly coexist. T2DM will disturb sleep patterns and disturbed sleep may predispose to insulin resistance resulting in T2DM. The study aim is to evaluate the prevalence of risk for Obstructive sleep apnea among T2DM patients based on patient demographic variables (age, gender and Body Mass Index (BMI)) and Berlin Questionnaire (BQ). In this cross-sectional study a total of 111 patients were included and the prevalence of risk was determined based on the BQ categories and the percentage was calculated accordingly. In BQ, Category 1 includes five questions based on snoring, category 2 includes three questions based on daytime somnolence and category 3 includes two questions based on BMI. These categories were marked as positive if the responses for snoring or daytime somnolence indicate persistent symptoms (> 3-4 times/week). Third category includes the patient’s BMI greater than 30 kg/m2 (obese) indicates positive score. In this study, the patients above 61 years (100%) and obese (94%) were at a higher risk for OSA. Based on the BQ, more positive (89.19%) responses were observed in category 1 (snoring) when compared to category 2 (40.54%) and 3 (74.77%) which concluded that T2DM patients are at a high risk (HR) for developing Obstructive Sleep Apnea.
Assessment of knowledge on hand hygiene among final year medical undergraduates
Authors: Khaja Moinuddin S  , Kavita Y  , Manibalan V  , Thirumaran  , Karthikeyan
Published: October 2020

Inadequate hand hygiene remains one of the main reasons for the spread of hospital-acquired infections, and now it is regarded as a key element of infection control activities. Hand hygiene practices are faulty in most healthcare settings. The present study was aimed to determine knowledge on hand hygiene among final year medical undergraduates. This was an institution-based descriptive cross-sectional study. The study was conducted at a tertiary care hospital and medical college in the department of obstetrics and gynaecology after obtaining ethical clearance from the institution. Informed consent was obtained from all the participants. All participants were given self-reporting questionnaires to fill. The questionnaire form contained questions based on hand hygiene knowledge assessment (obtained from the 2009 Global patient safety strategy initiative WHO guidelines). A total of 110 medical undergraduates were included in the study. (male,47 (42.7%) , female, 63(57.3%). A total of 14 participants scored less than 50% and accounted for 12.7%. Seventy-eight participants scored between 50-74, which accounted for 70.9%. It was noticed that good knowledge (≥ 75) on hand hygiene was least and accounted for 16.4%In the present study, knowledge on hand hygiene was found to be a moderate level in the majority of final year medical graduates.
Study of Clinical Profile of Neonatal seizures in a NICU of Rural Central India
Authors: Varma A  , Meshram R J  , Darvhekar N  , Patel Z  , Damke S G  , Taksande A
Published: October 2020

Seizures are common neonatal illness amongst neurological disorders. The study was conducted to determine the clinical profile of neonatal seizures. A hospital based prospective observational study was undertaken in the NICU of a rural set up in central India. A total of 82 neonates admitted with seizures or who developed seizures later during the stay in NICU were subject population of the study. Of 82 neonates with seizures, the overall mean for duration of stay was 14.34 (±10.41) days and the interquartile range was 1-32 days and male predominance. Majority of neonates included were extramural deliveries (62.19%). The distribution of neonates in the study according to their gestational age, birth weight, route of delivery & MSAF was found to be statistically insignificant (p Value >0.05). The vaginal route of delivery was more common than the caesarean section among neonates with seizures in the study. The overall mortality rate was 17.07% (14/82) .In most of the cases, the causes of neonatal seizures were present. Birth asphyxia was the main etiology identified. The antenatal services and intrapartum monitoring is important.
Transdermal drug delivery an emerging approach for antipsychotics
Authors: Akash Tekawade  , Tanaji Nandgude
Published: October 2020

Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.
Comparative Study of Desogestrel- Containing Oral Contraceptive and Levonorgestrel- Containing Oral Contraceptive in Dysfunctional Uterine Bleeding
Authors: Swathi Suresh  , Mariya Els Johny  , Kiruba Shankari  , Ahamed Irshath U  , Yokesh M  , Muddala Vara Prasanna Rao
Published: October 2020

Dysfunctional uterine bleeding is a type of abnormal uterine bleeding where vaginal bleeding occurs outside of the menstrual cycle in the absence of any known pelvic pathology. Dysfunctional uterine bleeding can be treated safely with hormone therapy. Combined oral contraceptives help in increased menstrual cycle regularity and decreased blood loss. In this study, a reliable drug for the dysfunctional uterine bleeding with maximum effectiveness and minimal side effects were assessed. This study was conducted on 120 cases of dysfunctional uterine bleeding. Patients who were diagnosed with dysfunctional uterine bleeding were randomly assigned into two groups. Group D and group L included patients who were given Ethinyl estradiol 0.02mg + desogestrel 0.15mg and Ethinyl estradiol 0.03mg + levonorgestrel 0.15mg respectively for the four consecutive 28- day cycles. Menstrual blood loss was assessed using the pictorial blood assessment chart (PBAC) score on 2nd and 4th months of recruitment. Side effects such as weight gain, acne and headache were assessed in both groups. This study shows 56.68% reduction in mean PBAC score in 2 months in desogestrel group whereas only 44.96% reduction in levonorgestrel group and 79.87% reduction in mean PBAC score in desogestrel group in 4 months whereas only 74.46% reduction in levonorgestrel group. Side effects like weight gain, acne and headache were more prominent in the levonorgestrel group than desogestrel group. Desogestrel containing combined oral contraceptive can be a useful and safe treatment for dysfunctional uterine bleeding.
Antibacterial activity of Acmella paniculata extracts against Streptococcus mutans
Authors: Nur Syahirah Binti Salehuddin  , Rohazila Binti Mohamad Hanafiah  , Siti Aisyah Abd Ghafar
Published: October 2020

Acmella paniculata, also known as 'Subang nenek' in Malaysia, has been used to treat diseases such as toothache and gum infections. People called it a toothache plant, and it has been widely used as traditional medicine. Therefore, this study aims to investigate the antibacterial activities of A. paniculata leaves and flowers extracts towards Streptococcus mutans by using disc diffusion assay, minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) methods. Besides, the anti-biofilm activity of all the extracts also been determined by using a crystal violet assay. As the results, n-hexane and methanol extracts from leaves showed the highest inhibition zone towards S. mutans  when compared to DCM and acetone extracts. Meanwhile, for the flowers extract, n-hexane and DCM showed the highest inhibition zone towards S. mutans compared to methanol and acetone extracts. The best results were then tested for MIC and MBC tests. As for the MIC values of n-hexane and methanol leaves extracts were 25 mg/mL, respectively, and the MBC values were 50 and 100 mg/mL, respectively. Whereas MIC values for n-hexane and DCM flowers extracts were 12.5 mg/mL, respectively, and the MBC values were 50 mg/mL, respectively. Biofilm formation of S. mutans  showed decrement up to 70% after exposure to both leaves extract (n-hexane and methanol) and n-hexane flower extract. Still, it differed when exposing to DCM flower extract, and the result showed that the biofilm activities of S. mutans were inhibited at 80% after treated with DCM flowers extracts. In conclusion, n-hexane leaves extract, methanol leaves extract, n-hexane flowers extract, and DCM flowers extract of A. paniculata demonstrated bactericidal properties against S. mutans.
In-vitro Anti-Inflammatory activity of Digera muricata Extracts
Authors: Balaji Subramaniyan R  , Jaikumar S  , Sekkizhar M
Published: October 2020

Inflammation is a process that is generally termed for pain and redness, which includes swelling. But it is defined as a heterogeneous group of processes which result in the pain and increase in vascular circulation and denaturation of protein that results in tissue degeneration. There are many synthetic drugs available to treat and relieve the inflammation. They are potent and have many side effects too. So there is an increased search for alternative means of treatment option. Thereby there was a high focus on the medicinal plants and herbs. Digera muricate, which is used to treat many diseases like analgesic activity, antidiabetic activity and anticancer activity too, this plant has proven to possess the antioxidant potential also. So there is no enough work done to verify the inflammatory potential of the plant. This was the primary consideration for this research to select the plant to prove it has anti-inflammatory potential. Having in the account that the ethical problems in the usage of lab animals, the anti-inflammatory potential of the plant was evaluated in-vitro using enzyme inhibition assays. The in-vitro models of the inflammatory activity are used for testing the anti-inflammatory activity, and the results were not different from invivo models. The extracts showed a dose based rise in the action, and the plant process a better anti-inflammatory activity than the standard drugs.
Anticancer activity of ylang-ylang essential oil in Ehrlich Ascites Carcinoma cell-treated mice
Authors: Ajay P Malgi  , Vijaykumar P Rasal  , Vishal Shivalingappa Patil  , Priyanka P Patil  , Shamanad P Mallapur  , Vrushabh B Hupparage  , Sathgowda A Patil
Published: October 2020

Essential oils are secondary metabolites contains a complex mixture of with a diverse array of chemical structures, play a crucial role in the management of complex diseases like cancer via synergistic and antagonism effect. essential oil (YYEO) extracted from the flowers of Cananga is renowned forits fragrance, contained more than 150 essential components within it, and utilized in various diseases and cosmetics. Traditionally YYEO is being used as an aphrodisiac, , , antiseptic, in food and beverages as a fragrance agent. Due to the presence of a complex mixture of essential components in YYEO, we aimed the current study to assess the anticancer potential against Ehrlich Carcinoma (EAC) bearing mice. In antioxidant, growth, body weight, biochemical, , and serum estimation was evaluated with subsequent of the liver. 5- (5- FU) was used as a standard drug. YYEO showed potent antioxidant activity by DPPH assay. YYEO significantly reversed the , lymphocytes, WBC, and RBC numbers in the treated group compared with the disease control group. YYEO administration has restored the imbalanced levels of antioxidant such as MDA, GSH, and SOD activity. YYEO reversed the of the liver altered by the EAC in mice. In conclusion, a complex mixture of contained in YYEO could be the potent anticancer therapy in the future. Further studies are needed to identify the active principles and the mechanism involved in this activity.
Evaluation of the analgesic activity of ethanolic extract of Populus deltoides leaves in mice
Authors: Vijay Bahadur Maurya  , Vishnu Prasad Yadav  , Vinay Kumar
Published: October 2020

The ethanolic leaves extract of Populus deltoides was tested for the presence of various phytoconstituents and designed to evaluate the analgesic activity in mice. The peripheral analgesic activity of ethanolic leaves extract of P.deltoides (250 and 500 mg/kg) was studied by using acetic acid stimulated writhing test and central analgesic activity of P.deltoides was studied by using hotplate process. The ethanolic leaves extract of P.deltoides  professed the existence of a variety of chemical constituents like alkaloids, saponins, flavonoids, terpenes and steroids. Leaves extract of P.deltoides appreciably decreased the writhing actions in acetic acid-induced writhing test in mice and amplified the respond time in hotplate test. These results suggest that the extract may have NSAIDs like activity through the peripheral mechanism and central analgesic activities via opioid receptors. From our study, we endowed that leaves extract of P.deltoides has feasible to analgesic activity. This study reveals that it can be used in the management of pain and provide a scientific basis for its traditional use.
Cissampelos capensis L.f. (Menispermaceae): Review of its medicinal uses, phytochemical and pharmacological properties
Authors: Alfred Maroyi
Published: October 2020

Cissampelos capensis L.f. is a perennial climber widely used as a traditional medicine in South Africa. This study was aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of C. capensis. Documented information on the pharmacological properties, phytochemistry and medicinal uses of C. capensis was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study revealed that leaf, rhizome and root infusions and decoctions of C. capensis are mainly used as a blood purifier, and traditional medicines for respiratory problems, ulcers, sores and wounds, skin and stomach cancers, snakebite, sexually transmitted infections, skin diseases, diabetes and gastrointestinal problems. Phytochemical compounds identified from the species include alkaloids, essential oils, flavonoids, phenolics, saponins and tannins. Pharmacological research revealed that C. capensis extracts and compounds isolated from the species have anthelmintic, antibacterial, antifungal, antidiabetic, antimalarial, hepatotoxicity, spermatozoa and cytotoxicity activities. Documentation of the medicinal uses, phytochemistry and pharmacological properties of C. capensis is vital as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. There is a need for extensive toxicological evaluations of crude extracts and compounds isolated from the species since C. capensis contains potentially toxic compounds.
The effectiveness of Acacia oral gel on wound healing in rabbits clinically and histopathologically
Authors: Sara Taha Ismail  , Eman Abdullah Sulaiman  , Noor A. Sulaiman
Published: October 2020

Oral mucosa considered as one of defensive mechanism of oral cavity, it is important in oral functions as eating, swallowing and even talking. Any wound or discontinuity effects on these functions so speeding the healing process with less inflammatory reactions is crucial, many herbs were used at different eras to reach this goal one of these herbs is Acacia plant. The aim of this study is to evaluate the effect of acacia oral gel extract on the wound healing. In materials and method This study include (twenty-one) male rabbits, (seven) for each group used for this study, two incisions of one centimeter length were made on buccal oral mucosa bilaterally one is treated by acacia oral gel while other left for normal healing, the follow up of the wound at twenty-four hours, three days and seven days clinically and histopathological examination were done. In result of this study, The study shows decrease in inflammatory reaction after seventy-two hours of the wound and increase in re-epithelialization rate in wound healing of acacia nilotica gel group, So it is concluded from this study that the acacia plant gel extract has anti-inflammatory effect and accelerate the wound healing of oral mucosa in rabbits.
Significance of accessory opening of maxillary air sinus
Authors: Shashikant Mane  , Ashwini Desai  , Rajiv Desai  , Priya Roy
Published: October 2020

Maxillary air sinus opens in hiatus semilunaris of middle meatus of the nasal cavity. Drainage of sinus should happen through a natural orifice. That is mandatory because there are cases where there is an additional opening of sinus posterior to the hiatus semilunaris. In this case, there may be recirculation of mucus between natural and accessory opening leading to complications and recurrence of the patient’s problem during various endoscopic procedures. So noting this high significance of accessory opening, the present study was conducted. Total of 50 specimens (27 were from the right side, and 23 were from the left side) was studied. Presence of accessory opening of maxillary air sinus was noted. Position of the opening was noted. The shape of the opening was noted. The diameter of the accessory opening was measured using Sliding Vernier Caliper. Observations on the above parameters show the accessory opening of maxillary air sinus was present in 21 specimens out of a total of 50 specimens (42%). Typical Shape of the opening on the left side was Circular and on the right side was Oval. The average diameter of the opening on the right side was 24mm and on the left side was 46mm. So definitely significance of the accessory opening of maxillary air sinus was found. That’s why surgeons, especially, Otorhinolaryngologists, should note and explore the exact position of the accessory opening of maxillary air sinus, during various sinus surgeries.
Evaluating the effectiveness of antiplatelet therapy of the patients with kidney disease
Authors: Nodir N. Sultonov  , Maksud O. Sabirov  , Mahsuma H. Tashpulatova  , Lola I. Maksudova
Published: October 2020

The study has evaluated the effectiveness of antiplatelet therapy of patients with chronic kidney disease. The patients were divided into two groups when treating the disease, the first group was given allthrombosepin as antiplatelet therapy, and the second group was given dipyridamole. The research work was monitored for ten days, during which the amount of urea in the blood was 9.6% compared to healthy people and a decrease in the amount of creatinine to 7.52%. Aggregation of thrombocytes was observed in the first group by 10.23%, and 9.6% was in the second group. As can be seen from the results obtained, it has been proved that dipyridamole did not lag in effectiveness, which was taken from the factory as an antiplatelet therapy and was used with the locally developed allthrombosepin, as traditional treatment, while treating chronic kidney disease (CKD).
Determination of significant parameters and optimization production of virgin coconut oil using Neurospora sitophila, Lactobacillus Plantarum, and papain
Authors: Futi Kusuma Hati  , Safri Ishmayana  , Ukun M.S. Soedjana Atmadja
Published: October 2020

Virgin coconut oil (VCO) is a processed coconut product that contains high acid which proved to have a health beneficial effect. Fermentation is one of the means to produce VCO. Factors that affect fermentation can be optimized to increase VCO recovery. The objective of the present study was to determine factors that significantly affecting VCO recovery using Plackett-Burman design (PBD), optimization of a fermentation process using Response Surface Methodology-Central Composite Design (RSM-CCD), and determine characteristics of a product. The experiment was performed by growing Neurospora and , isolation, and activity determination of from papaya sap. Nine factors were screened using PBD and the three most significant factors were further optimized using RSM-CCD. The optimum condition was applied to produce VCO and the product was characterized for its properties and fatty acid content. The results indicate that activity, incubation temperature, and pH were the most significant factors that affect VCO recovery. Further investigation using RSM-CCD indicates that optimum condition for VCO production was 1042.4 U, 46.4°C, and 5.07 for activity, incubation temperature, and pH, respectively. The recovery of VCO was 45.06 ± 0.42% and the properties of VCO comply to APCC quality standard of coconut oil requirement with 56.7% acid content.
Green synthesis of Selenium nanoparticles using Capparis decidua and its anti-inflammatory activity
Authors: Janani K  , Preetha S  , Jeevitha  , Rajeshkumar S
Published: October 2020

This in vitro study focuses on the green synthesis of selenium nanoparticles using Capparis decidua and its anti-inflammatory activity. Nanotechnology is the speciality associated with Material science and biology, rather than a particular field. It involves the formulation of particles at nanoscale known as Nanoparticles, where they have control over bulk macroscopic properties of the same material. Selenium, being a 'Drug nanocarrier', possesses strong antibacterial, antioxidant and anti-cancer as well as anti-inflammatory properties. As the medicinal plant Capparis decidua possesses a lot of phytochemicals, this study combined it to synthesise selenium nanoparticles, and anti-inflammatory properties were analysed. Synthesis of Selenium nanoparticles using Capparis decidua extract, collection of NPs using centrifugation, analysis of anti-inflammatory using UV spectroscopy and inhibition of Bovine serum albumin denaturation assay were performed. Biosynthesised selenium nanoparticles using Capparis decidua exhibit effective anti-inflammatory properties and act as an alternative candidate for steroidal and non-steroidal anti-inflammatory drugs. On account of performing the Green synthesis of selenium nanoparticles along with the combination of Capparis decidua, it is evident that Capparis decidua possesses effective anti-inflammatory with increasing concentrations up to 5muL. In future, we can encounter further efficacy by raising the concentrations by adding new formulations other than Capparis decidua
Method development and validation of droxidopa by HPLC technique
Authors: Bharani Pandilla  , Chitra K  , Nalini C N  , Ashok P
Published: October 2020

The purpose of this work is to develop and validate stability, indicating reverse phase High-performance liquid chromatography (HPLC) method for the rapid and precise determination of droxidopa in its pure form and formulations. A simple, fast, accurate and economical way has been developed and validated for the quantification of droxidopa by HPLC technique. The chromato graphic system was equipped with Shimpack columnC18((250x 4.6) mm, 5µ) as stationary phase and UV detector at 220 nm, in conjunction with a mobile phase of phosphate buffer pH 2.0:acetonitrile (60:40,% v/v) at a flow rate of 1.0 mL/min. The developed HPLC technique was found to be rapid as the retention time was 2.2 minutes for droxidopa peak to elute. The method was validated as per the International Conference on Harmonization (ICH) guidelines for specificity linearity, accuracy, precision. The developed method was selective with well-resolved peak. Linearity was observed over the concentration range of 25-150µg/mL for droxidopa. The recovery of Droxidopa was found to be 100.54% - 101.65%. Statistical techniques were employed for the validation of precision, linearity, accuracy, robustness and ruggedness and can be applied for routine analysis. Validation revealed that the developed method was specific, accurate, precise, reliable, robust, reproducible and suitable for the systematic quantitative review.
Prevalence of overweight, obesity and body weight perception among women above 30 years in Tirumazhisai, Chennai
Authors: Ragasudhin P  , Anantha Eashwar VM  , Ruma Dutta  , Nisha B  , Gomathy Parasuraman  , Yogesh Mohan  , Timsi Jain
Published: October 2020

Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. A WHO study was done in 2016 states that around 21.6% of Indian female population was overweight. This study aims to estimate the prevalence of overweight and obesity among women above 30 years of age in Tirumazhisai. A cross-sectional study was done among women above and equal to 30 years of age residing in Tirumazhisai from January 2020 to March 2020. A total of 172 subjects were included. Data entered in MS Excel and analyzed using proportion and Pearson's chi-square test. The prevalence of overweight and obesity among women equal and above 30 years of age in Tirumazhisai is found to be 36.7%. Majority of the subjects belonged to the age group more than 45 (61.3%). Also, 60.3% of people with unhealthy weight status were illiterate. Only 4.8% of the subjects with unhealthy weight status were in the obese class 2 category. About 55.5% of the subjects with unhealthy weight status were overweight, and 39.7 % of them were obese class 1. Around 60.3% of the subjects with unhealthy weight status were not working or being a housewife. Overall satisfactory level of physical activity among the unhealthy subjects was 62%. There was a significant association between age more than 45 years and the prevalence of overweight and obesity (at p<0.05). As the age increase, the chances of becoming obese or overweight becomes high. 40% of the unhealthy subjects didn't acknowledge their unhealthy weight status and 37% of them ignored the fact of obesity as a co-morbid condition. Hence efforts should be made to bring awareness among women about unhealthy weight status and its consequences.
Determination of in vitro antioxidant activity of the leaves extracts of Ehretia pubescens
Authors: Krishnamoorthy Meenakumari  , Giridharan Bupesh  , Mayur Mausoom Phukan
Published: October 2020

The foods from plants were known to ensure against degenerative diseases and maturing because of their antioxidant activitycredited to their high content. Information on antioxidant activity of Indian medicinal plant is abundant. To the best of our knowledge, biological properties have not been accounted in the literature for this species of . As a point, this is the first results to assess the anti-oxidant activity of the plant which belongs to the family . The antioxidant activity of Methanol, , Ethyl acetate and Aqueous extracts of E. was determined using the DPPH free radical scavenging activity, ABTS radical scavenging activity and reducing power assay. The DPPH scavenging activity showed higher activity observed in extract (63%) of E. than (54%), (44%) and aqueous (30%). the ABTS assay inhibition in extract (58%) than (43%), (38%) and aqueous (32%) extracts. The reducing power assay of different extracts was increased in extract (54%) than (40%), (34%) and aqueous (28%) extracts. Overall, the and ethyl acetate extract had higher antioxidant properties than other extract. However, in this study, extracts exhibit great potential for antioxidant activity and may be useful for their nutritional and medicinal functions.
Kinetic properties of glutamate metabolism in the nematode parasite Haemonchus contortus (L3)
Authors: Syahirah Sazeli  , Resni Mona  , Jannathul Firdous  , Noorzaid Muhamad
Published: October 2020

The key steps in cell metabolism of all organisms are the synthesis of both glutamate and glutamine because they denote the only means of incorporating inorganic nitrogen into carbon backbones. In this study, an assay for the activity of two key enzymes in nitrogen metabolisms such as glutamate dehydrogenase (GDH) and glutamine synthase (GOGAT) was conducted using homogenates of L3 larvae of Haemonchus contortus. GDH was assayed both in the direction of glutamate utilisation and glutamate formation. GOGAT activity was monitored in the direction of glutamine utilisation. The present result showed that H.contortus had a high Km for ammonia (27.22mM) and glutamine (15.04 mM). The high Km for ammonia suggests a very low affinity for ammonia, meaning that in the reversible amination of 2-oxoglutarate to glutamate, the predominant direction is likely to be glutamate deamination and not the incorporation of ammonia. The activity of GOGAT was also demonstrated but with a high Km, which indicates a low binding affinity of glutamine to the enzyme. Nevertheless, the presence of the two key enzymes of nitrogen metabolism, i.e. GDH and GOGAT, may provide a potential target for anthelmintic action.
Awareness of medicinal applications of alternanthera sessilis among dental students
Authors: Nithyanandham Masilamani  , Dhanraj Ganapathy
Published: October 2020

Alternanthera sessilis is a yearly or perpetual prostate weed, found all through the more smoking piece of India, climbing to a height of 1200 m. The plant has been scientifically demonstrated to comprise of substance constituents like α-and β-spinasterols, lupeal disconnected from roots. The aim of the study was to assess the awareness of medicinal applications of Alternanthera sessilis among dental students. A cross-sectional study was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about Alternanthera sessilis therapy in medical applications, their wound healing properties, anti glycemic applications, memory enhancement applications, anti-ulcer, diahorreal and anti-inflammatory activity. The responses were recorded and analysed. 91% of the respondents were not aware of medicinal applications of Alternanthera sessilis therapy. 85% were not aware of the wound healing properties of Alternanthera sessilis therapy. 87% were not aware of the anti glycaemic properties of Alternanthera sessilis therapy. 85% were not aware of memory enhancement properties of Alternanthera sessilis therapy. 89% were not aware of the anti-ulcer properties of Alternanthera sessilis therapy. 83% were not aware of ant diahorreal of Alternanthera sessilis therapy. 89% were not aware of the anti-inflammatory properties of Alternanthera sessilis therapy. The awareness about the use of Alternanthera sessilis therapy in medical applications is low among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications can further enhance knowledge and awareness about Alternanthera sessilis therapy.
Traumatic oral mucosal lesions in elderly dental patients - An institutional study
Authors: Aishwarya Reddy B  , Herald J. Sherlin  , Nivethigaa B
Published: October 2020

Oral trauma in elderly population constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function, which leads to loss of their capacity to respond to an injury. The aim of the study is to check the prevalence of traumatic oral mucosal lesions in elderly population/patients visiting a dental clinic. Elderly patients with oral mucosal lesions reported to dental hospitals were selected. Data from 86000 patients visiting Saveetha Dental College during the time period of June 2019 to March 2020 were reviewed, and the data was collected. This is a single centred retrospective study conducted in a private dental institution, Chennai. The collected data were tabulated and analysed using SPSS software by IBM. Out of 80 patients, 56.3% of the patients were of age 60 to 65 years. 42% of the patients had Denture stomatitis which was the highest among all the traumatic oral mucosal lesions. Males were more prevalent to oral mucosal lesions with 57.5% than females. The most common site with oral mucosal lesions is palate with 44%. The overall prevalence of traumatic oral mucosal lesions in the elderly population is high. Denture stomatitis is the most commonly occurring oral traumatic mucosal lesion among elderly patients visiting the dental clinic.
Assessment of oral health behaviour and knowledge among dental and engineering undergraduate students
Authors: Sundar R  , Yuvaraj Babu K  , Gayathri R
Published: October 2020

Oral health status is directly proportional to a person's oral health behaviour. Oral health of a person can be determined by their regular oral habits like brushing, flossing, smoking and regular dental check-up. Maintenance of poor oral health can lead to severe dental problems. The aim of the study is to create awareness about oral health and behaviour among the dental and engineering undergraduate students. The self-administered questionnaire prepared about oral health behaviour, distributed to 100 dental and engineering graduate students through online google link and data is collected and analysed. From the collected data, 87.18% of dental students brush daily, and 84.62% of engineering students use dental floss to clean the gap between the teeth. This survey helps to bring knowledge on the awareness of oral health behaviour among the dental and engineering students. From this survey, we have concluded that dental students have good oral hygiene when compared to engineering students.
2010-ben megjelent, jog- és államtudományi tárgyú könyvek annotált bibliográfiája – 2. rész
Authors: DE A DE jogi karának oktatói-hallgatói munkaközössége
Published: October 2020

Folyóiratunkban rendszeresen jelenik meg az elmúlt időszak új, hazai szakkönyveiről készült, annotált bibliográfia. Az annotáció a könyv felhasználhatóságáról írott, rövid, tényszerű leírás, amely a bibliográfiai adatok mellett meghatározza a műfajt, illetve röviden körvonalazza a feldolgozott témát és a bemutatott eredményeket is. Az annotációk szerzői valamilyen formában kivétel nélkül kötődnek a Debreceni Egyetem Állam- és Jogtudományi Karához, legyen szó munkatársainkról, óraadóinkról vagy hallgatóinkról, PhD-hallgatóinkról. Ebben a számban a 2010-ben megjelent könyvekről készült leírások második részét közöljük.
A 2012-ben megjelent jog- és államtudományi tárgyú könyvek annotált bibliográfiája – 2. rész
Authors: DE A DE jogi karának oktatói-hallgatói munkaközössége
Published: October 2020

Folyóiratunkban rendszeresen jelenik meg az elmúlt időszak új, hazai szakkönyveiről készült, annotált bibliográfia. Az annotáció a könyv felhasználhatóságáról írott, rövid, tényszerű leírás, amely a bibliográfiai adatok mellett meghatározza a műfajt, illetve röviden körvonalazza a feldolgozott témát és a bemutatott eredményeket is. Az annotációk szerzői valamilyen formában kivétel nélkül kötődnek a Debreceni Egyetem Állam- és Jogtudományi Karához, legyen szó munkatársainkról, óraadóinkról vagy hallgatóinkról, PhD-hallgatóinkról. Ebben a számban a 2012-ben megjelent könyvekről készült leírások második részét közöljük.
2013-ban megjelent jog- és államtudományi tárgyú könyvek annotált bibliográfiája – 1. rész
Authors: DE A DE jogi karának oktatói-hallgatói munkaközössége
Published: October 2020

Folyóiratunkban rendszeresen jelenik meg az elmúlt időszak új, hazai szakkönyveiről készült, annotált bibliográfia. Az annotáció a könyv felhasználhatóságáról írott, rövid, tényszerű leírás, amely a bibliográfiai adatok mellett meghatározza a műfajt, illetve röviden körvonalazza a feldolgozott témát és a bemutatott eredményeket is. Az annotációk szerzői valamilyen formában kivétel nélkül kötődnek a Debreceni Egyetem Állam- és Jogtudományi Karához, legyen szó munkatársainkról, óraadóinkról vagy hallgatóinkról, PhD-hallgatóinkról. Ebben a számban a 2013-ban megjelent könyvekről készült leírások első részét közöljük.
Pola Pendidikan Karakter di Kalangan Keluarga Nelayan
Authors: Khobir Abdul
Published: October 2020

Penelitian ini bertujuan untuk mendeskripsikan implementasi pendidikan karakter di kalangan keluarga nelayan dusun Jambean desa Pecakaran Kecamatan Wonokerto Kabupaten Pekalongan, untuk mendeskripsikan pola pendidikan karakter di Kalangan Keluarga Nelayan Dusun Jambean desa Pecakaran kecamatan Wonokerto Kabupaten Pekalongan, dan untuk mendeskripsikan faktor-faktor apa saja yang mempengaruhi pola Pendidikan karakter di Kalangan Keluarga Nelayan dusun Jambean desa Pecakaran Kecamatan Wonokerto Kabupaten Pekalongan? Pendekatan dalam penelitian ini menggunakan jenis pendekatan kualitatif. Sedangkan jenis penelitian yang digunakan adalah penelitian lapangan (field research). Sumber data dalam penelitian ini menggunakan sumber data primer dan sumber data sekunder. Teknik pengumpulan data dalam penelitian ini menggunakan; metode wawancara, metode observasi, dan metode dokumentasi. Sementara teknik analisis datanya menggunakan analisis data kualitatif deskriptif. Hasil penelitian menunjukkan bahwa: Pertama, Implementasi pendidikan karakter di kalangan keluarga nelayan dusun Jambean bisa dilihat dari beberapa aspek antara lain: dari aspek pengertian pendidikan karakter, tujuan pendidikan karakter, materi pendidikan karakter dan metode pendidikan karakter. Kedua, pola pendidikan karakter yang diberikan oleh orang tua di kalangan keluarga nelayan dusun Jambean antara lain: mendidik dengan kesabaran, mendidik dengan kasih sayang, mendidik dengan penelantar, mendidik dengan pola otoriter dan mendidik dengan pola demokrasi, dan Ketiga, faktor–faktor  yang mempengaruhi pola pendidikan karakter di kalangan keluarga nelayan dusun Jambean desa Pecakaran Kecamatan Wonoerto Kabupaten Pekalongan meliputi dua faktor, yaitu pertama, faktor pendukung meliputi: faktor pembiasaan dan teladan, faktor lingkungan sekitar, faktor pembiasaan, serta faktor kesadaran dan kedua, faktor penghambat meliputi; faktor lingkungan, faktor kurangnya perhatian orang tua, faktor pendidikan dan agama orang tua.
Propellant Actuated Device for Parachute Deployment during Seat Ejection for an Aircraft Application
Authors: Parate Bhupesh Ambadas
Published: October 2020

Propellant Actuated Devices (PAD) are installed on various combat aircraft of Air Force and Naval bases to perform extremely important operations such as parachute deployment, harness and leg restrain, cable cutting, pullers, seat ejection, bomb release or fuel tanks etc. They are basically called as gas generators. Such devices produce the high temperature and pressure combustion gases on initiation and used to perform different operations. These cartridges are single-shot operating devices. The performance of such kind of PADs cannot be tested by non-destructive techniques. Hence, cartridges are designed to function with high reliability and stringent quality control checks at all levels during entire development cycle. The safety features required during handling, storage and transportation are built in the design of PAD. The cartridges are required to undergo different exhaustive design qualification tests to qualify design aspects. Total life of 6 years is assigned to cartridge after performance degradation study of the propellant which includes 2 years installed life. This paper explains about the development aspects of PAD, its use, function, testing and performance evaluation methodology in a suitable fabricated Velocity Test Rig (VTR). The maximum slug velocity is 121.14 m/s in hot condition and minimum slug velocity is 99.14 m/s in cold condition. The main objective of this paper is to device a novel method to measure actual slug velocity of the aircraft gun inside a cartridge using VTR and Doppler RADAR.