bluuebunny/crossref_metadata_2025 huggingface dataset:
Postal Bank in Ukraine: The Need and Risks of Creation
Authors:   The National Institute for Strategic Studies, Hladkykh D. M.
Published: August 2021

The article is aimed at substantiating the feasibility of creating a specialized postal bank in Ukraine, to define the list of related risks and possible directions for their reduction. The following key risks that hinder the establishment of a postal bank in Ukraine are identified: risk of lack of full control over the directions of investment of accumulated deposits of the population on the part of the NBU; liquidity risk; risk of non-compliance by the postal operator with economic standards that are mandatory for banking institutions; risk of capital deficit; risk of inability to support the postal operator with refinancing; risk of mass withdrawal of deposits by customers; risk of insufficient competence of «Ukrposhta» employees to comply with the requirements of financial monitoring; risks associated with the collection of large amounts of cash; risk of further growth of the share of the State-owned institutions in the banking market; risk of shortage of funds to close the agreement on the purchase of «Ukrposhta» by an already operating bank. Possible directions of minimization of these risks are proposed, in particular: implementation of key elements of successful experience in the banking services market of JSPPB «Aval»; defining as the target segment of clients of the new postal bank of the pensioners, who are currently customers of post offices, and as the basis of its resource base – the future pension and current accounts of individuals; use by «Ukrposhta» of the so-called «agency» model of financial services provision; association of «Ukrposhta» and «Oschadbank» into the State-owned Postal Bank; development of a list of key performance indicators for employees and branches of the new postal bank; development of a list of measures directed towards significantly improving the level of qualification of personnel of «Ukrposhta» branches; installation of POS-terminals and payment terminals in all post offices located in rural areas; establishment of individual economic standards for the new postal bank for the period of its full adaptation to activities in the banking market.
The Methodical Instrumentarium for Analysis and Evaluation of Financial Potential of the Fuel and Energy Complex Enterprises
Authors:   Vasyl’ Stus Donetsk National University, Savchenko M. V. , Filipchuk A. S. ,   Joint Stock Company «Khmelnytskoblenergo»
Published: August 2021

The article is aimed at substantiating and validating the methodical instrumentarium for analyzing and evaluating the financial potential of the enterprises in the fuel and energy complex, which provides for the diagnosis of existing and the detection of possible financial resources, as well as determining the type of financial potential. As result of the research, it is determined that ensuring the effective functioning of enterprises in the fuel and energy complex requires the development of a methodical approach to evaluating the level of their financial potential. The article systematizes methodical approaches to defining the system of parameters for evaluation of the financial potential of enterprise. The analysis of current methodological approaches helped to draw the authors’ own conclusions and emphasize the shortcomings of using various methods for evaluating the financial potential. The result of the analysis of the current methodological approaches to evaluating the financial potential of the fuel and energy complex enterprises was the conclusions on the need to improve the methodical instrumentarium for analyzing and evaluating the financial potential of enterprise. The article substantiates the stages of evaluation of the financial potential of an enterprise of the fuel and energy complex. On the basis of the proposed approach, the type of financial potential of JSC «Khmelnytskoblenerho» is determined. Prospects for further research in this direction are the substantiation of the evaluation of the financial potential of enterprises in the fuel and energy complex on the basis of a taxonomic approach, also, at the conceptual level there is a need to closer define several concepts and their logical use in practical activities.
Trust Marketing in the Stakeholder Network: Mechanism, Sources and Process of Forming Trust Relationships
Authors:   Kharkiv Institute of Trade and Economics of Kyiv National University of Trade and Economics, Bazaliieva L. V.
Published: August 2021

The presented publication is aimed at determining the mechanism and sources of formation of trust relationships in the stakeholder network and closer defining the content of the process of their formation. The article defines the most significant sources of formation and strengthening of trust relations at the microeconomic level, which are: openness and availability of information; solving social problems; ability of each participant in the relationship to express their interests and influence the decision-making; integrity, honesty and competence of managers; clear feedback; stability of contractual relations and partnerships; high reputation and developed organizational culture of companies. Trust in the stakeholder network has a mechanism of occurrence, which consists of an aggregate of trust states of participants in relationships and processes by which these states are formed in them. Determining the sources of trust and the mechanism of its occurrence in the stakeholder network gives grounds for the development and adjustment, if necessary, of the process of establishing and developing trust relationships between network members. The incentive, cognitive, instrumental, practical and final stages of the process of formation of trust relations in the stakeholder network are also allocated, which makes it possible to structure the process of trust formation in the system of relations between the company and stakeholders and harmonize it with the stakeholder analysis and management process.
Penyuluhan Tentang Persiapan Persalinan Pada Ibu Hamil Trimester III Di Puskesmas Sukamaju Bandar Lampung
Authors: Hadiarto Rinto , Khoirunnissa Dian , Purwaningrum Ratna , Utami Deviani , Arania Resti , Mandala Zulhafis
Published: August 2021

ABSTRAK Persiapan persalinan yang direncanakan bersama bidan diharapkan dapat mengurangi ketidaksiapan ibu saat persalinan dan meningkatkan ibu akan menerima asuhan yang optimal. Penelitian untuk mengetahui hubungan pengetahuan dengan perilaku ibu hamil trimester III dalam persiapan persalinan. Penelitian ini adalah penelitian deskriptif analitik dengan rancangan Cross Sectional. Populasi adalah semua ibu hamil trimester III berjumlah 12 ibu hamil, Sampel penelitian adalah total populasi yaitu 12 ibu hamil. Penelitian menunjukkan pengetahuan ibu hamil sebagian besar memiliki pengetahuan baik sebanyak 12 (100%) dan perilaku ibu hamil dalam persiapan persalinan sebagian besar perilaku positif sebanyak 12 (100%). Kesimpulan: ada hubungan pengetahuan dengan perilaku ibu hamil trimester III dalam persiapan persalinan di Puskesmas Sukamaju, Bandar Lampung. Kata Kunci : Pengetahuan, Perilaku, Persiapan Persalinan  ABSTRACT It is hoped that the preparation for childbirth that is planned with the midwife will reduce the unpreparedness of the mother during childbirth and increase the mother's acceptance of optimal care. Research to determine the relationship between knowledge and behavior of third-trimester pregnant women in preparation for delivery. This research is a descriptive-analytic study with a cross-sectional design. The population was all pregnant women in the third trimester, amounting to 12 pregnant women. The research sample was the total population, namely 12 pregnant women. The study showed that most of the pregnant women had good knowledge as much as 12 (100%) and the behavior of pregnant women in preparation for labor was mostly positive behavior as many as 12 (100%). Conclusion: there is a relationship between knowledge and behavior of third-trimester pregnant women in preparation for childbirth at Puskesmas Sukamaju, Bandar Lampung.  Keywords: Knowledge, Behavior, Birth Preparation
Penyuluhan Tentang Proteksi Diri Di Era New Normal Dan Worskshop Pembuatan Sediaan Herbal Berpotensi Imunomodulator
Authors: Rahmiyani Ira , Ruswanto Ruswanto , Yuliana Anna , Nurviana Vera , Nofianti Tita , Amin Saeful , Lestari Tresna , Faturohman M. , Pratita Anindita Tri Kusuma , Alifiar Ilham
Published: August 2021

ABSTRAK Dengan meningkatkan kasus covid-19 yang terjadi di dunia dan khususnya di Indonesia serta munculnya konsep new normal, maka perlu langkah-langkah untuk antisipasi mengurangi penyebaran covid-19 di era new normal ini. Sehingga Prodi Farmasi STIKes Bakti Tunas Husada telah melakukan beberapa kegiatan pengabdian masyarakat di Kota Tasikmalaya tentang penyuluhan proteksi diri di era new normal dan workshop pembuatan sediaan herbal sebagai imunomodulator. Metode yang digunakan dalam kegiatan pengabdian masyarakat adalah ceramah, diskusi dan workshop. Peserta kegiatan ini adalah kader-kader kecamatan dan Penanggung jawab kesehatan tradisional di tiap puskesmas Kota Tasikmalaya. Dari kegiatan pengabdian yang dilakukan dapat berjalan dengan lancar dan sukses serta peserta dapat memahami materi yang disampaikan. Keyword: covid-19, new normal, proteksi diri, imunomodulator  ABSTRACT By increasing cases of Covid-19 that have occurred in the world and especially in Indonesia and the emergence of the new normal concept, steps are needed to anticipate reducing the spread of Covid-19 in this new normal era. So that the Pharmacy Program at STIKes Bakti Tunas Husada has carried out several community service activities in the Tasikmalaya City regarding self-protection counseling in the new normal era and workshops on making herbal preparations as immunomodulators. The methods used in community service activities are lectures, discussions, and workshops. Participants in this activity are sub-district cadres and people in charge of the traditional health of each puskesmas at Tasikmalaya City. The service activities carried out can run smoothly and successfully and participants can understand the material presented. Keywords: covid-19, new normal, immunomodulator, self-protection
Implementasi Senam Dysmenorrhoea Pada Remaja Premenstruasi Syndrome Di SMAN 15 Bandar Lampung
Authors: Sunarsih Sunarsih , Bustami Anita , Fatonah Siti
Published: August 2021

ABSTRAK Angka kejadian dismenorrhoea di Indonesia tahun 2011 sebanyak 64,25%, terdiri dari 54,89% mengalami dysmenorrhoea primer dan hanya 20% yang tidak mengalami dismenorrhoea. Remaja putri di SMAN 15 sejumlah 256 Siswa, remaja putri sejumlah 176 orang yang mengeluhkan nyeri haid dari sedang sampai dengan berat. Dismenorrhoea sangat mengganggu aktivitas belajar siswa dan emosi remaja. Permasalahan yang muncul pada remaja adalah ketidaknyamanan dalam melakukan pembelajaran, sehingga angka ketidakhadiran di kelas menjadi lebih banyak. Pengabdian kepada masyarakat yang dilakukan bertujuan untuk mengurangi nyeri melalui senam dismenorrhoea dan mengupayakan siswa dapat beradaptasi dengan nyeri haid yang dialami. Hasil pengabdian kepada masyarakat sejumlah 150 siswa dan guru telah diberikan informasi tentang fisiologi haid dan permasalahannya serta upaya mengatasinya, termasuk mendapatkan leaflet dan video senam dismenorrhoea. Siswa dan guru antusias mengikuti kegiatan penyuluhan, interaksi aktif berjalan baik narasumber maupun peserta. Hasil penyuluhan diharapkan guru dan siswa yang dilatih senam dapat mengatasi permasalahan dismenorrhoea dan memberikan informasi kepada teman sebaya jika mengalami dismenorrhoea.Kata kunci: Dysmenorrhoea, pre menstruasi, senam  ABSTRACT The incidence of dysmenorrhoea in Indonesia in 2011 was 64.25%, consisting of 54.89% experiencing primary dysmenorrhoea and only 20% experiencing dysmenorrhoea. 256 students and 176 young women complained of moderate to severe menstrual pain. Dysmenorrhoea very disturbs student learning activities and adolescent emotions. The problem that arises in adolescents is the discomfort in learning so that the number of absenteeism in class is higher. The community service that is carried out aims to reduce pain through dysmenorrhoea exercise and strive for students to adapt to menstrual pain experienced. The results of community service, a number of 150 students and teachers, have been given information about the physiology of menstruation and its problems and efforts to overcome them, including obtaining leaflets and videos of dysmenorrhoea exercise. Students and teachers enthusiastically participate in counseling activities, active interaction runs both the resource person and the participants. The results of the counseling are expected that teachers and students who are trained in gymnastics can overcome dysmenorrhoea problems and provide information to peers if they experience dysmenorrhea. Keywords: Dysmenorrhoea, pre-menstruation, exercise
Pembinaan Panti Rehabilitasi
Authors: Ananda Ramon , Rosyidi Hamim
Published: August 2021

Hilangnya kebermaknaan hidup bagi warga binaan panti merupakan fenomena yang sering terjadi di sekitar masyarakat kita. Warga binaan panti yang merupakan individu lanjut usia (lansia) sering mengalami penyebab yang kurang menyenangkan ketika harus tinggal di panti, sering mengalami tekanan baik secara fisik maupun psikologis. Pendampingan dan pemberdayaan yang dilakukan di UPT Pelayanan Sosial Tresna Wherda ini lebih kepada memperkuat kapasitas diri melalui kebermaknaan hidup melalui optimalisasi nilai-nilai religiusitas yang ada pada diri warga binaan tersebut. Metode yang digunakan terhadap pendampingan ini yaitu pendekatan Asset-Based Community-driven Development (ABCD). Pendekatan ini sangat tepat jika digunakan untuk mengoptimalkan potensi-potensi yang ada dalam diri individu terutama potensi religiusitas untuk menemukan kebermaknaan hidup serta dapat secara efektif menggali dan menemukan makna dari kehidupan yang mulai memudar ketika terjadi proses adaptasi yang sulit. Hasil dari pendampingan dan pemberdayaan ini terhadap warga binaan di pusat rehabilitasi yaitu adanya rasa optimisme yang tinggi dalam menyongsong kehidupan walaupun mereka jauh dari keluarga, dapat merasakan Allah SWT sebagai Rahman dan Rahim ketika dalam  susasana yang prihatin, dapat beribadah lebih leluasa, dan dapat lebih tenang dalam memaknai kehidupan religiusitasnya serta siap dalam menjalani tugas kehidupan atau berfungsi secara sosial. Hasil dari pengabdian ini memperlihatkan adanya potensi yang tumbuh kembali setelah warga mulai tinggal di panti. Perubahan itu terlihat dengan adanya perubahan pada aspek-aspek kebermaknaan hidup mulai dari dimensi personal, dimensi sosial, dan dimensi nilai-nilai.
Labor-Induced Pregnancy Cases In Dr Soetomo General Hospital: A Descriptive Study
Authors: Firasy Alfin
Published: August 2021

Background: Labor induction is a procedure to stimulate uterine contractions during pregnancy before labor begins on its own to achieve a vaginal birth with medical or mechanical intervention to start the labor. This procedure aims to stimulate more extensive contraction in the uterus. The labor induction can reduce the caesarean rate. Prostaglandin E2 (PGE2) and misoprostol are the commonest medicine used to ripen the cervix in the Dr. Soetomo Hospital.
Objective: Our study aim to evaluate the success rate of induction of labor patient.
Methods: This study was a descriptive study using the medical record in 2018 in the Dr. Soetomo General Hospital, Surabaya. A total of 183 patient’s medical record data who underwent induced labor were used in this study. Inclusion criteria were the women with indication to deliver and have no cephalo-pelvic disproportion. Women with contraindication labor induction were excluded. Data was described using table and narrative approach.
Results: The most range of gestational age was 21-36 weeks (53.01%) followed by 37-42 weeks (42.07%). There were 68 patients (37,1%) primigravida and 115 patients (62,8%) were multipara. The major induced labor was conducted with misoprostol (78.6%), and the most pelvic scores were 2 (58.46%) before underwent induced labor. Vertex delivery was the preferred mode of delivery after the induction of labor with 89 patients (48,62%). The labor induction failure followed with the caesarean operation were 27 patients (14,7%) and one patient (0,54%) with hysterotomy, most of them caused by failure to progress and fetal distress. There were 78 babies (43%) with the weight over 2500 g, 28 babies (31%) were over 2000 g, and the other was below 2000 g. A total of 84.71% with labor induction can be delivered vaginally, and It is a good number to reduce the rate of caesarean operations.
Conclusion: This study concludes that misoprostol uses for the induction of labor than the other. Delivery abdominal is less percentage than the additional delivery finds that as a failure of induction of labor. The Labor induction success to delivered vaginally can reduce the rate of caesarean operation.
Pre Clinic Grade and Clinic Periods Effect on Progress Test of UNISMA Medical Profession Students
Authors: Ratri Dewi Ariani
Published: August 2021

Introduction: Pre clinic grade point is often seen as predictor of good performance in professional education whose short term goal is to pass national examination which command progress test to evaluate the preparation.
Purpose: To know the effect of pre clinic grade point and clinical study periods in progress test result of medical profession students.
Methods: 135 students of medical profession programme completed computer based progress test of 200 national standardized questions in 200 minutes using siPENA software. Progress test result then analysed based on how long they have been studied and their pre clinic grade point using ANOVA – Tukey HSD and Pearson correlation in SPSS for Windows ver 19
Results: Although students with pre clinic grade 2,50-2,74 have lower progress test result, but it’s not statistically significant (p>0,05). The same happen in clinic study periods with the longer the students in their clinical rotation, the better their result (p>0,05). The trends which showing better result in higher pre clinic grade point and time they spend in clinical rotation agrees with previous studies.
Conclusion: Pre clinic grade point and clinic study periods has little to no effect on progress test result of medical profession students in UNISMA.
An in silico evaluation of CDK Inhibitors targeting BCL2, TS and mTOR
Authors: Rakhi Sharmin Ahmed , Asaduzzaman Muhammad , Nasin Nishat , Md Khademul Islam Abul Bashar Mir
Published: August 2021

The cyclin dependent kinase (CDK) inhibitors have recently been found to be of potential use as anticancer drugs. The present research work focuses on screening of compounds targeting multiple pathways involved in human cancers along with CDK-regulated cell cycle for prospective anticancer potential. Molecular docking study of selected compounds were performed to determine the binding affinity of selected compounds towards respective targets of cancer cells to verify if there is any physical interaction of these inhibitors with their reported target proteins as claimed in the existing literatures. Prior to docking, molecular pathway prediction and gene set enrichment analyses were performed to identify the target molecules by using appropriate bioinformatics tools. Interestingly, the results of in silico molecular docking have been found to be in line with the laboratory findings that are obtained from the literatures. Specifically, few of our selected CDK inhibitors, namely Abemaciclib, Palbociclib, AMG 925 and RGB 286638 showed good binding scores against BCL2, TS, mTOR in addition to CDKs (4, 6 and 9). On the basis of scientific evidence based on published scholarly articles and according to molecular docking results, it can be inferred that these CDK inhibitors as anticancer agents may play a very promising role in cancer treatment and can be used as potential lead compounds for the development of target therapy against human cancers. However, more intensive research is needed to confirm the feasibility of these compounds to be used in treating cancer and it is expected that this work will provide a stimulating impetus for the development of chemotherapeutic agents in future.
Asian J. Med. Biol. Res. 2021, 7 (2), 126-131
People’s knowledge regarding impacts of air pollution on reproductive health: a self-reported study
Authors: Majumder Ahmad Kamruzzaman , Meem Romana Afrose , Hoque Ariful , Ara Marufa Gulshan , Nayeem Abdullah Al
Published: August 2021

Air pollution is a major challenge worldwide, particularly in the developing world. This study aimed to revelation people’s perceptions regarding the impacts of air pollution on reproductive health. This study was conducted among107 respondents and a google form was used to create a survey questionnaire. Purposive sampling has been used to select the respondents. A large number of respondents are male and aged less than 30 years. A large number of respondents are from the urban area and depends on Non-Government Job. A satisfactory number of the respondents know about air pollution. Both male and female respondents know smoke inhalation during pregnancy, damage reproductive organs of the male, birth defects due to air pollutions, and delayed brain development of the newborn baby. Most of the respondents gather their knowledge from television and social media.
Asian J. Med. Biol. Res. 2021, 7 (2), 147-152
Socio-economic status of fisher communities in Dengar beel under Melandah Upazila, Jamalpur, Bangladesh
Authors: Islam Md Fakhrul , Haque Syed Ariful , Islam Md Saiful , Das Partha Sarathi , Rahman Mizanur
Published: August 2021

The current study was conducted to evaluate the socio-economic profile of fisher communities in Dengar beel under Melandah Upazila of Jamalpur district, Bangladesh. A total of 45 fishers were surveyed from November 2020 to April 2021. It was found that the family size of 53% of fishers was medium, consisting of 5-6 members. Most of the fisher communities belonged to the age group above 45 years old, represented by 100% Muslim. About 73% of fishers were less educated, 13% primary level, 7% secondary level, and 7% Secondary School Certificate passed and above, respectively. Most of the fishers (60%) have katcha houses with tin roofing, 7% have katcha house with straw roofs, 13% have semi- pucca houses and 20% have pucca houses. Around 93% of fishers used their own tube-well while only 7% used neighbours’ tube-well. All of the fisher household were connected with electricity supply. About 27% of fisher communities used katcha toilets, 46% used semi pucca toilets and 27% used pucca toilets. About 47% of fisher communities were dependent on village doctors, 33% got health service from Upazila health complex, 20% from MBBS doctors, and others. About 46% of fishers were engaged in fishing as their primary occupation while 27% in agriculture with fishing, 20% in daily labour with fishing and 7% in livestock rearing. About 33% of the fishers had low income, 40% had medium income and 27% had high income. The present study revealed that the fishers of Dengar Beel were mostly less educated, less privilege to attain modern technology-oriented training experience, less income and less awareness about sanitation and health facilities. So, provide soft loans to fishers, and strengthening people awareness has been might be helpful to improve the socio-economic status of fisher communities in Dengar Beel.
Asian J. Med. Biol. Res. 2021, 7 (2), 164-173
Fish culture in net cages improves the livelihood of Charland population: a case study from Padma (Ganga) River, Munshiganj, Bangladesh
Authors: Saha Tutul Kumar , Hosen Jannatul , Hossain Zakir
Published: August 2021

Char dwellers are considered poorer than the mainland population. A constant threat of riverbank failure, flooding, and seasonal cyclone, combined with lack of physical infrastructures, and employment opportunities in the Chars, makes a vulnerable, difficult, and fragile life. The aim of the present work was an initiative to improve the livelihood of Char dwellers through fish culture in the net cages. A focus group survey was conducted on Char dwellers to know about the livelihood conditions. Quantitative and qualitative analysis of plankton was performed to know the productivity of the Padma River. In the study area, there was an average of 5 household members in each family of the Charland dwellers, and the average sex ratio of males and females was 56.67% and 43.33%, respectively. The age group of below 15 to 60 years and their religion ratio of Muslim and Hindu was 45% and 55%. The total number of identified genera of phytoplankton was 41, and the total number of zooplankton genera was 20 in the Padma River. Tilapia (Oreochromis niloticus) was cultured in the net cages providing three different feeds i.e. natural feed, kitchen waste (leftover rice), and rice bran. The final weights of the experimental tilapia were 314.8 ± 24.3 g after 5 months of feeding natural food, 321.4 ± 22.8 g after 5 months of feeding natural food with kitchen waste, and 324.8 ± 29.5 g after 5 months of feeding natural food with rice bran. Considering the plankton populations and water quality parameters, the Padma River near the Charland of Munshiganj was productive for fish farming. We found the results of Genetically Improved Farmed Tilapia (GIFT) farming in net cages near the river of Char, which were almost the same (has no significant difference among the diets) by providing low-cost supplementary feed and without supplementary feed. Therefore, the result indicates that Char dwellers can culture fishes in net cages to have the fish in their daily meals and can earn extra income from selling the fish to improve their livelihood. Moreover, applied research and interdisciplinary adaptive policy framework are requisite for the Charland livelihoods sustainability in the Padma River, Munshiganj, Bangladesh.
Asian J. Med. Biol. Res. 2021, 7 (2), 174-181
Spatiotemporal variation of erosive rainfall and its influence on sediment discharge in the Ganjiang River Basin
Authors: Guo LP , Chen XL , Liao KT , He Y , Zheng TH , Nie XF , Xu BS , Zhang LC , Luo ZJ
Published: August 2021

Expected increases in extreme rainfall events due to global warming could lead to increased soil erosion in mountainous areas. In order to study this impact on specific areas, the present study identified the spatiotemporal variation of erosive rainfall and the influence of its variation on streamflow and sediment discharge within the Ganjiang River Basin. Daily average rainfall data were obtained from 23 national meteorological observation stations along with streamflow and sediment concentration data collected for 1964-2013 at 6 control stations. The nonparametric Mann-Kendall method and Pettitt test were used for trend analysis and change-point detection, and the modified double mass curve method was used to quantify the effects of both erosive rainfall variation and human activities on hydrological regime shifts. Results showed significant monthly variation in erosive rainfall and significant increases in rainstorms over the entire watershed, particularly in the downstream subzone and northeast corner of the upstream subzone. While moderate rain showed an insignificant decrease in both subzones and the entire watershed, heavy rain showed no significant variation over the entire watershed but did show a significant increase in both the midstream and downstream subzones. The changes in accumulative erosive rainfall had only small effects on reduction in sediment discharge after the change-point year. In contrast, human activities contributed to more than 50% of the changes in sediment discharge in the entire basin. These findings provide a research basis for the study of extreme climate, flood disaster prevention, and soil erosion prediction over the entire watershed.
Recovery from ‘schizophrenia’: Perspectives of mental health nurses in the Eastern island of Indonesia
Authors: Tasijawa Fandro Armando , Suryani Suryani , Sutini Titin , Maelissa Sinthia Rosanti
Published: August 2021

Background: Recovery is a way of life to make people’s lives more meaningful by working and interacting socially in the community. The recovery has become a new vision of mental health services, including in persons with schizophrenia. However, this concept is relatively new and still limited to nurses in developing countries, such as Indonesia. Several studies among nurses related to this topic have been conducted in the Western part of Indonesia. Yet, no studies have been implemented in the Eastern part of Indonesia. Therefore, exploring nurses’ perspectives in the Eastern island of Indonesia is necessary to provide a complete understanding of recovery in patients with schizophrenia.Objective: To explore the perspectives of mental health nurses on recovery from schizophrenia. Methods: This was a qualitative study using a phenomenological design. The study was conducted from April to May 2020 at community health centers in Maluku, Indonesia. Eight nurses recruited using purposive sampling participated in in-depth interviews. The interviews were audio-recorded, transcribed verbatim, validated, and analyzed based on Colaizzi’s method of data analysis.Results: Five themes were generated, including (i) treat a patient like a brother, (ii) recovery as an unfamiliar term with various meanings, (iii) medication as the primary action but also the main problem, (iv) being recovered if referred to a mental hospital, and (v) ineffective mental health programs.Conclusion: The findings of this study can be used as an input and evaluation for nurse managers to make an effort to uniform the perception among nurses in Indonesia regarding the recovery process in schizophrenia. It is also suggested that community health centers leaders and mental health policymakers prioritize and optimize recovery-oriented mental health programs and services in the Eastern island of Indonesia. Additionally, the findings offer new insight about ‘we are brothers’ or called ‘hidop orang basudara’, which is expected to be one motto for nursing care in Indonesia and beyond.
Individual Rights in Disputes between States
Authors: Juratowitch Ben , McNamara Natasha
Published: August 2021

This article is concerned with ways in which international courts and tribunals take into account the rights and interests of individuals when they are affected by a dispute between states concerning the direct rights and obligations of those states under international law.
Ponzi Schemes in Ghana: The Menzgold Saga
Authors: Amponsah-Mensah Afia Agyeman
Published: August 2021

Ponzi schemes have ravaged financial markets and have caused considerable financial loss to many individuals. The continuous emergence of Ponzi schemes is as a result of a lacuna in financial regulation. The collapse of Menzgold, a company in Ghana, is another episode in the ebb and flow of Ponzi schemes in Ghana. This article therefore exploits this recent development to explain the emergence of Ponzi schemes in Ghana and situates this trend in the context of the lapses in financial regulation. In doing this, both the doctrinal approach and the comparative approach are applied in this article to contribute to the little Ghanaian literature there is on Ponzi schemes and regulation in Ghana.
Entanglement-Based Feature Extraction by Tensor Network Machine Learning
Authors: Liu Yuhan , Li Wen-Jun , Zhang Xiao , Lewenstein Maciej , Su Gang , Ran Shi-Ju
Published: August 2021

It is a hot topic how entanglement, a quantity from quantum information theory, can assist machine learning. In this work, we implement numerical experiments to classify patterns/images by representing the classifiers as matrix product states (MPS). We show how entanglement can interpret machine learning by characterizing the importance of data and propose a feature extraction algorithm. We show on the MNIST dataset that when reducing the number of the retained pixels to 1/10 of the original number, the decrease of the ten-class testing accuracy is only O (10–3), which significantly improves the efficiency of the MPS machine learning. Our work improves machine learning’s interpretability and efficiency under the MPS representation by using the properties of MPS representing entanglement.
Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels
Authors: Reina-Romo Esther , Mandal Sourav , Amorim Paulo , Bloemen Veerle , Ferraris Eleonora , Geris Liesbet
Published: August 2021

Research in bioprinting is booming due to its potential in addressing several manufacturing challenges in regenerative medicine. However, there are still many hurdles to overcome to guarantee cell survival and good printability. For the 3D extrusion-based bioprinting, cell viability is amongst one of the lowest of all the bioprinting techniques and is strongly influenced by various factors including the shear stress in the print nozzle. The goal of this study is to quantify, by means of in silico modeling, the mechanical environment experienced by the bioink during the printing process. Two ubiquitous nozzle shapes, conical and blunted, were considered, as well as three common hydrogels with material properties spanning from almost Newtonian to highly shear-thinning materials following the power-law behavior: Alginate-Gelatin, Alginate and PF127. Comprehensive in silico testing of all combinations of nozzle geometry variations and hydrogels was achieved by combining a design of experiments approach (DoE) with a computational fluid dynamics (CFD) of the printing process, analyzed through a machine learning approach named Gaussian Process. Available experimental results were used to validate the CFD model and justify the use of shear stress as a surrogate for cell survival in this study. The lower and middle nozzle radius, lower nozzle length and the material properties, alone and combined, were identified as the major influencing factors affecting shear stress, and therefore cell viability, during printing. These results were successfully compared with those of reported experiments testing viability for different nozzle geometry parameters under constant flow rate or constant pressure. The in silico 3D bioprinting platform developed in this study offers the potential to assist and accelerate further development of 3D bioprinting.
PI3K Plays an Essential Role in Planarian Regeneration and Tissue Maintenance
Authors: Zheng Hanxue , Liu Hongbo , Xu Qian , Wang Wenjun , Li Linfeng , Ye Gang , Wen Xiaomin , Chen Fulin , Yu Yuan
Published: August 2021

Phosphatidylinositol 3-kinase (PI3K) signaling plays a central role in various biological processes, and its abnormality leads to a broad spectrum of human diseases, such as cancer, fibrosis, and immunological disorders. However, the mechanisms by which PI3K signaling regulates the behavior of stem cells during regeneration are poorly understood. Planarian flatworms possess abundant adult stem cells (called neoblasts) allowing them to develop remarkable regenerative capabilities, thus the animals represent an ideal model for studying stem cells and regenerative medicine in vivo. In this study, the spatiotemporal expression pattern of Djpi3k, a PI3K ortholog in the planarian Dugesia japonica, was investigated and suggests its potential role in wound response and tissue regeneration. A loss-of-function study was conducted using small molecules and RNA interference technique, providing evidence that PI3K signaling is required for blastema regrowth and cilia maintenance during planarian regeneration and homeostasis. Interestingly, the mitotic and apoptotic responses to amputation are substantially abated in PI3K inhibitor-treated regenerating animals, while knockdown of Djpi3k alleviates the mitotic response and postpones the peak of apoptotic cell death, which may contribute to the varying degrees of regenerative defects induced by the pharmacological and genetic approaches. These observations reveal novel roles for PI3K signaling in the regulation of the cellular responses to amputation during planarian regeneration and provide insights for investigating the disease-related genes in the regeneration-competent organism in vivo.
Study of lncRNA TPA in Promoting Invasion and Metastasis of Breast Cancer Mediated by TGF-β Signaling Pathway
Authors: Li Qinglin , Mo Wenju , Ding Yuqin , Ding Xiaowen
Published: August 2021

Purpose

This study was to investigate the effects of lncRNA TPA overexpression and knockdown in stable transfected cell lines on the EMT, migration and invasion capabilities of breast cancer cells.

Methods

WB and qRT-PCR were used to detect the expression of E-cadherin, Vimentin, fibronectin and N-cadherin, the key molecules of EMT, to determine whether lncRNA regulates EMT; scratch, migration and invasion assay were used to detected the effect of lncRNA TPA on the migration and invasion of breast cancer cells. The effect of lncRNA TPA on breast cancer metastasis was observed in nude mice model. Pierce Magnetic RNA-Protein Pull-Down Kit was used to bind the 3′-terminal desulfurized biotin-labeled lncRNA TPA with Magnetic beads, and then incubated with the proteins extracted from cell line C and D, respectively. After elution of the binding proteins, the interacting proteins were further identified by mass spectrometry to screen out the interacting proteins. The candidate proteins were expressed and purified in vitro, and the interaction between lncRNA-candidate proteins were verified by RNA-EMSA.

Results

Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-β1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01). Multiple lung metastases were observed in the lung tissue of nude mice with overexpression of lncRNA TPA.

Conclusion

LncRNA TPA affects the occurrence of breast cancer EMT through TGF-β signaling pathway, and then promotes the invasion and metastasis of breast cancer. LncRNA TPA may affect the corresponding signaling pathways through one or more interacting proteins, and ultimately promote the invasion and metastasis of breast cancer.
Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man
Authors: Sinenko Sergey A. , Starkova Tatiana Yu. , Kuzmin Andrey A. , Tomilin Alexey N.
Published: August 2021

Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced NADPH oxidases in the cytosol. In the recent two decades, a plethora of studies established that elevated ROS levels generated by oxidative eustress are crucial physiological mediators of many cellular and developmental processes. In this review, we discuss the mechanisms of ROS generation and regulation, current understanding of ROS functions in the maintenance of adult and embryonic stem cells, as well as in the process of cell reprogramming to a pluripotent state. Recently discovered cell-non-autonomous ROS functions mediated by growth factors are crucial for controlling cell differentiation and cellular immune response in Drosophila. Importantly, many physiological functions of ROS discovered in Drosophila may allow for deciphering and understanding analogous processes in human, which could potentially lead to the development of novel therapeutic approaches in ROS-associated diseases treatment.
Structural and Nanotribological Properties of a BODIPY Self-Assembly
Authors: Tan Shanchao , Luo Wendi , Zhang Yongjie , Ren Xiang-Kui , Liu Yuhong , Chen Zhijian , Zeng Qingdao
Published: August 2021

Boron-dipyrromethenes (BODIPY) are promising functional dyes, whose exceptional optical properties are closely related to their supramolecular assembly. Herein, the self-assembly of a BODIPY derivative functionalized with uracil groups is explicitly and thoroughly investigated by using scanning tunneling microscopy (STM). Based on the simulation and calculation by density functional theory (DFT) method, it can be concluded that the construction of ordered self-assembly structure is attributed to the formation of hydrogen bonds between uracil groups. Moreover, the nanotribological property of the self-assembly on HOPG surface is measured by using atomic force microscopy (AFM). The effort on self-assembly of the BODIPY derivative could enhance the understanding of surface assembly mechanism.
“Maybe a Long Fast Is Good for You”: Health Conceptualisations in YouTube Diet Videos
Authors: Chiu Mu-Chi , Penders Bart
Published: August 2021

In this paper, we study which health conceptualisations are promoted or supported by intermittent fasting, no-carb-no-sugar, and endomorph Diet YouTubers and how they relate to existing definitions of health. In order to openly understand how YouTubers present health concepts, we will study health conceptualisations in YouTube diet videos qualitatively, through the use of thematic analysis. We identify five main themes: weight management, prior dietary awareness, diet literacy, quality of life, and the satisfaction of functional needs. We find that YouTubers substitute the WHO’s pursuit of a complete state of well-being by an implicit, tacit version of new health concepts. The tacit form allows them to stay practical and to focus on real-world dietary concerns, such as answers to the simple question “what should I eat to stay healthy?”. Diet YouTubers do not, however, neatly position themselves within existing health conceptualisations and they offer views on health that move beyond “formal” conceptualisations, including self-inspection, timing, preparation and planning and context-design. Differing from the universal definitions of health, the Diet YouTubers we studied target specific audiences with their presentations of healthy eating.
Asymmetric Forms of Linguistic Adaptation in Interactions Between Flemish and Dutch Speakers
Authors: Swerts Marc , Van Heteren Anouk , Nieuwdorp Chloë , Von Oerthel Eline , Kloots Hanne
Published: August 2021

Conversation partners tend to copy elements of each other’s utterances during a spoken interaction. This article investigates possible asymmetries in this adaptive process. We study game-based dialogues between Flemish and Dutch speakers, who officially speak the same language, but who can differ in their default use of words and in their pronunciation. Our general hypothesis, mainly based on previous studies that focused on long-term forms of adaptation and on previous studies on exchanges between categorical and variable language users, is that Flemish speakers adapt more in interactions towards Dutch speakers, than vice versa. The article describes two experiments using variants of the same experimental paradigm. Experiment 1 investigates lexical adaptation and tests whether Flemish speakers indeed adapt more to Dutch ones than the other way around. Experiment 2 looks at how adaptation of lexical forms relates to adaptation in terms of pronunciation. Both experiments bring to light that Flemish speakers indeed converge more to Dutch ones, than vice versa, especially in terms of choice of lexical forms.
Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19
Authors: Law Ching Chee , Puranik Rajesh , Fan Jingchun , Fei Jian , Hambly Brett D. , Bao Shisan
Published: August 2021

Atherosclerosis, which is a primary cause of cardiovascular disease (CVD) deaths around the world, is a chronic inflammatory disease that is characterised by the accumulation of lipid plaques in the arterial wall, triggering inflammation that is regulated by cytokines/chemokines that mediate innate and adaptive immunity. This review focuses on IL-32, -34 and -37 in the stable vs. unstable plaques from atherosclerotic patients. Dysregulation of the novel cytokines IL-32, -34 and -37 has been discovered in atherosclerotic plaques. IL-32 and -34 are pro-atherogenic and associated with an unstable plaque phenotype; whereas IL-37 is anti-atherogenic and maintains plaque stability. It is speculated that these cytokines may contribute to the explanation for the increased occurrence of atherosclerotic plaque rupture seen in patients with COVID-19 infection. Understanding the roles of these cytokines in atherogenesis may provide future therapeutic perspectives, both in the management of unstable plaque and acute coronary syndrome, and may contribute to our understanding of the COVID-19 cytokine storm.
Older Adults Engage With Personalized Digital Coaching Programs at Rates That Exceed Those of Younger Adults
Authors: Graham Sarah A. , Stein Natalie , Shemaj Fjori , Branch OraLee H. , Paruthi Jason , Kanick Stephen Chad
Published: August 2021

Background: The US population is aging and has an expanding set of healthcare needs for the prevention and management of chronic conditions. Older adults contribute disproportionately to US healthcare costs, accounting for 34% of total healthcare expenditures in 2014 but only 15% of the population. Fully automated, digital health programs offer a scalable and cost-effective option to help manage chronic conditions. However, the literature on technology use suggests that older adults face barriers to the use of digital technologies that could limit their engagement with digital health programs. The objective of this study was to characterize the engagement of adults 65 years and older with a fully automated digital health platform called Lark Health and compare their engagement to that of adults aged 35–64 years.

Methods: We analyzed data from 2,169 Lark platform users across four different coaching programs (diabetes prevention, diabetes care, hypertension care, and prevention) over a 12-month period. We characterized user engagement as participation in digital coaching conversations, meals logged, and device measurements. We compared engagement metrics between older and younger adults using nonparametric bivariate analyses.

Main Results: Aggregate engagement across all users during the 12-month period included 1,623,178 coaching conversations, 588,436 meals logged, and 203,693 device measurements. We found that older adults were significantly more engaged with the digital platform than younger adults, evidenced by older adults participating in a larger median number of coaching conversations (514 vs. 428) and logging more meals (174 vs. 89) and device measurements (39 vs. 28) all p ≤ 0.01.

Conclusions: Older adult users of a commercially available, fully digital health platform exhibited greater engagement than younger adults. These findings suggest that despite potential barriers, older adults readily adopted digital health technologies. Fully digital health programs may present a widely scalable and cost-effective alternative to traditional telehealth models that still require costly touchpoints with human care providers.
Is the Automation of Digital Mental Health Ethical? Applying an Ethical Framework to Chatbots for Cognitive Behaviour Therapy
Authors: Vilaza Giovanna Nunes , McCashin Darragh
Published: August 2021

The COVID-19 pandemic has intensified the need for mental health support across the whole spectrum of the population. Where global demand outweighs the supply of mental health services, established interventions such as cognitive behavioural therapy (CBT) have been adapted from traditional face-to-face interaction to technology-assisted formats. One such notable development is the emergence of Artificially Intelligent (AI) conversational agents for psychotherapy. Pre-pandemic, these adaptations had demonstrated some positive results; but they also generated debate due to a number of ethical and societal challenges. This article commences with a critical overview of both positive and negative aspects concerning the role of AI-CBT in its present form. Thereafter, an ethical framework is applied with reference to the themes of (1) beneficence, (2) non-maleficence, (3) autonomy, (4) justice, and (5) explicability. These themes are then discussed in terms of practical recommendations for future developments. Although automated versions of therapeutic support may be of appeal during times of global crises, ethical thinking should be at the core of AI-CBT design, in addition to guiding research, policy, and real-world implementation as the world considers post-COVID-19 society.