bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Geopolymer Foams for Multifunctional Applications
Authors: Boros Adrienn , Korim Tamás
Published: March 2022

Due the increasingly stringent environmental regulations and sustainable development-induced pressures to increase efficiency, the world faces new challenges. For this reason, the production of structural materials with controlled properties has become urgent. Due to their excellent mechanical and chemical properties and energy-efficient production methods, geopolymers have remarkable potential in higher value-added applications. This potential application exceeds their historical use as environmentally friendly substitutes for Portland cement. The aim of the present research is to produce metakaolin-based geopolymer foams using the combined technique of saponification/peroxide decomposition/gel casting. Concerning physical properties, the effect of H2O2 concentration, the type and amount of stabiliser and the addition of slag were investigated. XRD, FTIR, SEM, CT and thermogravimetric analyses were performed to characterise the material structure. Multifunctional geopolymer foams were developed that can be made free of organic matter and cracks through the optimisation of technological parameters (heat treatment, washing and firing). Such high strength (8.9 MPa), lightweight (~499 kg/m3) and low thermal conductivity (~0.041 W/mK) foams can be used as thermal insulating materials to reduce the energy loss of buildings. Due to their high open porosity (~77.7 vol%) and specific surface area (~4.3 m2/g), foamed geopolymers can function as catalyst supports in many physicochemical applications.
Impact of Selected Serum Factors on Metastatic Potential of Gastric Cancer Cells
Authors: Tkacz Marta , Tarnowski Maciej , Poniewierska-Baran Agata , Serwin Karol , Madej-Michniewicz Anna , Deskur Anna , Czerny Bogusław , Starzyńska Teresa
Published: March 2022

(1) Background: stromal-derived factor-1 (SDF-1/CXCL12), hepatocyte and vascular-endothelial growth factors (HGF and VEGF) have been shown to facilitate cell motility, proliferation and promote local tumor progression and metastatic spread. Recent research shows the important role of these cytokines in gastric cancer (GC) progression. (2) Methods: 21 gastric cancer patients and 19 healthy controls were included in the study. SDF-1, HGF and VEGF levels were evaluated in sera by ELISA. Patients and control sera were used to stimulate CRL-1739 GC cell line, and chemotaxis, adhesion and proliferation potential were assessed. (3) Results: Concentrations of SDF-1, HGF and VEGF were significantly higher in patients than in controls. Chemotaxis and adhesion assays revealed a significant response of GC cells to patients’ serum. Furthermore, significant relationships were seen between chemotactic/adhesion response and tumor stage. Serum from intestinal early GC patients produced significantly stronger chemotactic response when compared to patients with metastatic spread. In turn, serum from patients with distal metastases significantly increased the adhesion of GC cells when compared to sera from the patients with no distal metastases. We also observed that HGF strongly stimulated the proliferation of CRL-1739 cells. (4) Conclusions: We observed that the sera from GC patients, but also SDF-1, HGF and VEGF used alone, have a strong pro-metastatic effect on CRL-1739 cells. We also demonstrated that the concentration of these cytokines is specifically elevated in the sera of patients in an early stage of malignancy. Our results indicate that SDF-1, HGF and VEGF are very important molecules involved in gastric cancer progression.
Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response
Authors: Trifan Anca , Stratina Ermina , Rotaru Adrian , Stafie Remus , Zenovia Sebastian , Nastasa Robert , Huiban Laura , Sfarti Catalin , Cojocariu Camelia , Cuciureanu Tudor , Muzica Cristina , Chiriac Stefan , Girleanu Irina , Singeap Ana-Maria , Stanciu Carol
Published: March 2022

Chronic hepatitis C virus (HCV) infection induces hepatic steatosis due to viral and host factors. However, information regarding the effects of direct-acting antivirals (DAAs) therapy on liver steatosis and fibrosis is limited. Vibration-controlled transient elastography (VCTE) with a controlled attenuation parameter (CAP) represents a non-invasive method, which has been used in the last few years for the detection of hepatic steatosis and fibrosis before and at a sustained virological response at 12 weeks (SVR12). The aim of this study was to assess the modifications of liver steatosis and fibrosis in HCV-infected patients who achieved SVR12. Consecutive patients with chronic HCV infection that were treated with DAAs in a tertiary gastroenterology center from Romania were included. Demographics, laboratory data, and VCTE evaluation were recorded in all patients. Patients with previous hepatic decompensation and those who did not achieve SVR were excluded. Two hundred and eighty patients (67.1% females) who achieved SVR12 were included. Regarding the changes in biological parameters, including liver enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), reduced to normal levels at SVR12 compared to the baseline (28.72 ± 24.71 U/L vs. 40.72 ± 27.34 U/L for ALT, p < 0.013 and 27.21 ± 11.15 U/L vs. 33.35 ± 23.37 U/L for AST, p = 0.029). On the contrary, the levels of triglycerides increased significantly from the baseline to SVR12 (124.03 ± 113.49 mg/dL to 153.78 ± 94.53, p = 0.004). Regarding hepatic steatosis by CAP evaluation, at SVR12, 186 (66.4%) of the individuals had a CAP score of ≥248 dB/m, an increase of 4.6% from the baseline. After viral eradication with DAAs, we observed an increase in hepatic steatosis. Hence, a long-term follow-up is mandatory to identify HCV-infected patients with hepatic steatosis post-SVR and the risk factors for more severe outcomes.
Increased Levels of ICOS and ICOSL Are Associated to Pulmonary Arterial Hypertension in Patients Affected by Connective Tissue Diseases
Authors: Bellan Mattia , Murano Francesco , Ceruti Federico , Piccinino Cristina , Tonello Stelvio , Minisini Rosalba , Giubertoni Ailia , Sola Daniele , Pedrazzoli Roberta , Maglione Veronica , Manfredi Giulia Francesca , Acquaviva Antonio , Piffero Roberto , Patti Giuseppe , Pirisi Mario , Sainaghi Pier Paolo
Published: March 2022

Background: Pulmonary hypertension (PH) is a life-threatening complication of connective tissue diseases (CTD); in this study, we aimed at investigating the potential role of inducible co-stimulator (ICOS) and its ligand (ICOS-L) as biomarkers of PH in CTD. Materials and Methods: We recruited 109 patients: 84 CTD patients, 13 patients with CTD complicated by pulmonary arterial hypertension (PAH), and 12 subjects with PAH alone. All recruited patients underwent a complete clinical and instrumental assessment along with quantitative measurement of serum ICOS and ICOS-L. Results: Independently of the underlying cause, patients with PAH were older and had a lower glomerular filtration rate. Interestingly, patients with both CTD-related and CTD-unrelated PAH had higher ICOS and ICOS-L serum concentrations than CTD patients (0.0001 for both). When compared to CTD patients, those affected by CTD-PAH showed higher ICOS (440 (240–600) vs. 170 (105–275) pg/mL, p = 0.0001) and ICOS-L serum concentrations (6000 (4300–7000) vs. 2450 (1500–4100) pg/mL; p = 0.0001). In a logistic regression, ICOS and ICOS-L were associated with a diagnosis of PAH, independently from age, gender, and renal function. The corresponding receiver operating characteristic (ROC) curves demonstrated a good diagnostic performance for both ICOS and ICOS-L. Conclusions: ICOS and ICOS-L are increased in patients with PAH, irrespectively from the underlying cause, and represent promising candidate biomarkers for the diagnostic screening for PAH among CTDs patients.
Sentiment Classification Method Based on Blending of Emoticons and Short Texts
Authors: Zou Haochen , Xiang Kun
Published: March 2022

With the development of Internet technology, short texts have gradually become the main medium for people to obtain information and communicate. Short text reduces the threshold of information production and reading by virtue of its short length, which is in line with the trend of fragmented reading in the context of the current fast-paced life. In addition, short texts contain emojis to make the communication immersive. However, short-text content means it contains relatively little information, which is not conducive to the analysis of sentiment characteristics. Therefore, this paper proposes a sentiment classification method based on the blending of emoticons and short-text content. Emoticons and short-text content are transformed into vectors, and the corresponding word vector and emoticon vector are connected into a sentencing matrix in turn. The sentence matrix is input into a convolution neural network classification model for classification. The results indicate that, compared with existing methods, the proposed method improves the accuracy of analysis.
Cohort-Based Education and Other Factors Related to Student Peer Relationships: A Mixed Methods Social Network Analysis
Authors: Mauldin Rebecca L. , Barros-Lane Liza , Tarbet Zachary , Fujimoto Kayo , Narendorf Sarah C.
Published: March 2022

Graduate students face a variety of stressors that relate to poor academic performance, lower completion rates, and high rates of depressive symptoms, anxiety, and stress. Student peers provide supports for coping with these stressors and succeeding academically. However, graduate students may find it difficult to form relationships with their peers. This mixed method social network analysis (MMSNA) examines graduate student perceptions of their peer relationships and the factors associated with peer friendships in a program that placed students in cohorts for the first semester of a two-year Master of Social Work program. Findings from three student focus groups include four main themes related to the cohort system and the tendency for students to gravitate to others who were similar to them (i.e., homophily). Focus group findings informed model specification for a curved exponential family model of student friendships at the end of the third semester of the program (N = 70) that identified correlates of student friendships including statistically significant direct and homophily effects for age, gender, and race/ethnicity. First-semester relationships and shared classes in subsequent semesters also increased the likelihood of friendships in the third semester. Findings emphasize the value of cohorts and a diverse student body for peer relationships.
Potentials and Opportunities of Wild Edible Forest Fruits for Rural Household’s Economy in Arasbaran, Iran
Authors: Ghanbari Sajad , Weiss Gerhard , Liu Jinlong , Eastin Ivan , Fathizadeh Omid , Moradi Gholamhosein
Published: March 2022

Non-timber forest products (NTFPs) contribute to local people’s livelihood in many regions around the world. This article investigates the types of NTFPs collected, processed, and traded in the Arasbaran region of Iran, the roles of these products in household economies, and the potential contribution to rural household economies through the collection, processing, and marketing of NTFPs. Data were collected using household and community surveys as well as through secondary sources on the role of NTFPs within Arasbaran forests in Iran. The main NTFPs harvested by local people were fruits. The fruits from 14 woody species, including trees and shrubs, were harvested by local people. The average share of forest-harvested fruit to household income was 27 percent. The mean annual income derived from the harvest and sale of sumac and reddish blackberry in the sample rural household incomes was USD 1822 and USD 142, respectively. In regard to processing efficiency, plum, cornelian cherry, and sumac exhibited the highest processing efficiency. Better policy support would be needed along the whole value chain, starting with the forest management plans, to include fruit species. In addition, measures to support processing facilities as well as to promote trade and marketing beyond the local area would be highly important to develop the potential of forest fruits and other NTFPs. Besides technical and financial support, measures should include regulatory revisions as well as information, training, and awareness raising.
What Gastroenterologists Should Know about Carcinoid Syndrome
Authors: Magi Ludovica , Rinzivillo Maria , Panzuto Francesco
Published: March 2022

Carcinoid syndrome (CS) is the most common functional syndrome associated with neuroendocrine neoplasia (NEN), particularly in intestinal NEN with extensive liver metastases. Owing to the heterogenous symptomatic scenario present in CS, recognition of these patients may be challenging. In this review, we explore some key clinical factors used to identify patients affected by CS, with particular focus on differential diagnoses of diarrhea, which is the main symptom of CS. Moreover, we highlight the importance of nutritional screening as a clinical indication to prevent malnutrition and to manage the most common nutrient deficiencies present in these patients.
Repurposing Lovastatin Cytotoxicity against the Tongue Carcinoma HSC3 Cell Line Using a Eucalyptus Oil-Based Nanoemulgel Carrier
Authors: Rizg Waleed Y. , Hosny Khaled M. , Mahmoud Samar S. , Kammoun Ahmed K. , Alamoudi Abdulmohsin J. , Tayeb Hossam H. , Bukhary Haitham A. , Badr Moutaz Y. , Murshid Samar S. A. , Alfayez Eman , Ali Sarah A. , Mushtaq Rayan Y. , Abualsunun Walaa A.
Published: March 2022

Tongue cancer is one of the most common carcinomas of the head and neck region. The antitumor activities of statins, including lovastatin (LV), and the essential oil of eucalyptus (Eu oil), have been adequately reported. The aim of this study was to develop a nanoemulgel containing LV combined with Eu oil that could then be made into a nanoemulsion and assessed to determine its cytotoxicity against the cell line human chondrosarcoma-3 (HSC3) of carcinoma of the tongue. An I-optimal coordinate-exchange quadratic mixture design was adopted to optimize the investigated nanoemulsions. The droplet size and stability index of the developed formulations were measured to show characteristics of the nanoemulsions. The optimized LV loaded self-nanoemulsifying drug delivery system (LV-Eu-SNEDDS) was loaded into the gelling agent Carbopol 934 to develop the nanoemulgel and evaluated for its rheological properties. The cytotoxic efficiency of the optimized LV-Eu-SNEDDS loaded nanoemulgel was tested for cell viability, and the caspase-3 enzyme test was used against the HSC3 cell line of squamous carcinoma of the tongue. The optimized nanoemulsion had a droplet size of 85 nm and a stability index of 93%. The manufactured nanoemulgel loaded with the optimum LV-Eu-SNEDDS exhibited pseudoplastic flow with thixotropic behavior. The developed optimum LV-Eu-SNEDDS-loaded nanoemulgel had the best half-maximal inhibitory concentration (IC50) and caspase-3 enzyme values of the formulations developed for this study, and these features improved the ability of the nanoemulsion-loaded gel to deliver the drug to the investigated target cells. In addition, the in vitro cell viability studies revealed the synergistic effect between LV and Eu oil in the treatment of tongue cancer. These findings illustrated that the LV-Eu-SNEDDS-loaded gel formulation could be beneficial in the local treatment of tongue cancer.
Clinical and Genetic Aspects of Phelan–McDermid Syndrome: An Interdisciplinary Approach to Management
Authors: Cammarata-Scalisi Francisco , Callea Michele , Martinelli Diego , Willoughby Colin Eric , Tadich Antonio Cárdenas , Araya Castillo Maykol , Lacruz-Rengel María Angelina , Medina Marco , Grimaldi Piercesare , Bertini Enrico , Nevado Julián
Published: March 2022

Phelan–McDermid syndrome (PMS) is a rare, heterogeneous, and complex neurodevelopmental disorder. It is generally caused by a heterozygous microdeletion of contiguous genes located in the distal portion of the long arm of chromosome 22, including the SHANK3 gene. Sequence variants of SHANK3, including frameshift, nonsense mutations, small indels and splice site mutations also result in PMS. Furthermore, haploinsufficiency in SHANK3 has been suggested as the main cause of PMS. SHANK3 is also associated with intellectual disability, autism spectrum disorder and schizophrenia. The phenotype of PMS is variable, and lacks a distinctive phenotypic characteristic, so the clinical diagnosis should be confirmed by genetic analysis. PMS is a multi-system disorder, and clinical care must encompass various specialties and therapists. The role of risperidone, intranasal insulin, insulin growth factor 1, and oxytocin as potential therapeutic options in PMS will be discussed in this review. The diagnosis of PMS is important to provide an appropriate clinical evaluation, treatment, and genetic counseling.
MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case–Control Study
Authors: Faisal Salwa , Toraih Eman A. , Atef Lina M. , Hassan Ranya , Fouad Marwa M. , Al Ageeli Essam , Fawzy Manal S. , Abdalla Hussein Abdelaziz
Published: March 2022

Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for the first time, the miR-17-92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. We also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) and the available clinical data. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated for each genetic association model. The upregulation of miR-17 was observed in the serum of patients with alopecia compared to controls (p-value = 0.004). The ROC curve showed high diagnostic performance of miR-17 in differentiating between patients and controls (AUC = 0.85, p-value < 0.001). rs4284505*A/G heterozygotes were more susceptible to the disease (OR = 1.57, 95% CI = 1.01–2.45) under the over-dominant model. Interestingly, patients with the rs4284505*G/G genotype had a higher level of miR-17 than those with the A/A and A/G genotypes. The G/G genotype was associated with the severe phenotype (p-value = 0.038). A/G carriers were the youngest (p-value < 0.001), had more frequent scalp infection (p-value = 0.006), exhibited the worst dermatology life quality index score (p-value = 0.037), and responded less to treatment (p-value = 0.033). In conclusion, MIR17HG expression and the rs4284505 variant were significantly associated with AA and could play a role in pathogenesis and phenotype in the Egyptian population. Further multi-center studies in other ethnicities are warranted to replicate the findings.
2022 Overview of Metabolic Epilepsies
Authors: Tumiene Birute , Ferreira Carlos R. , van Karnebeek Clara D. M.
Published: March 2022

Understanding the genetic architecture of metabolic epilepsies is of paramount importance, both to current clinical practice and for the identification of further research directions. The main goals of our study were to identify the scope of metabolic epilepsies and to investigate their clinical presentation, diagnostic approaches and treatments. The International Classification of Inherited Metabolic Disorders and IEMbase were used as a basis for the identification and classification of metabolic epilepsies. Six hundred metabolic epilepsies have been identified, accounting for as much as 37% of all currently described inherited metabolic diseases (IMD). Epilepsy is a particularly common symptom in disorders of energy metabolism, congenital disorders of glycosylation, neurotransmitter disorders, disorders of the synaptic vesicle cycle and some other IMDs. Seizures in metabolic epilepsies may present variably, and most of these disorders are complex and multisystem. Abnormalities in routine laboratory tests and/or metabolic testing may be identified in 70% of all metabolic epilepsies, but in many cases they are non-specific. In total, 111 metabolic epilepsies (18% of all) have specific treatments that may significantly change health outcomes if diagnosed in time. Although metabolic epilepsies comprise an important and significant group of disorders, their real scope and frequency may have been underestimated.
Emergency Nursing-Care Patient Satisfaction Scale (Enpss): Development and Validation of a Patient Satisfaction Scale with Emergency Room Nursing
Authors: Haruna Junpei , Minamoto Naomi , Shiromaru Mizue , Taguchi Yukiko , Makino Natsuko , Kanda Naoki , Uchida Hiromi
Published: March 2022

This study aimed to develop and validate an emergency nursing-care patient satisfaction scale to measure patient satisfaction with emergency room (ER) nursing. Patient satisfaction scales for ER nursing have been validated without considering the perspectives of the healthcare system or cultural background of the country. Moreover, although nursing care is changing with COVID-19, no scale has been specifically designed to assess patient satisfaction with ER nursing. The study population included patients who visited five ERs in Japan (March to December 2021) (n = 135). The rating scales were provided to patients who visited the ER and gave consent, and the patients were asked to reply. In the process of validating the scale, exploratory and confirmatory factor analyses of the construct and criterion validity were conducted. The confirmatory factor analysis results showed a factorial structure consisting of four factors. The domain and summary scores demonstrated good-to-excellent internal reliability (Cronbach’s range = 0.81–0.89). This patient satisfaction scale was designed and validated from the perspective of the Japanese healthcare system and cultural backgrounds. This scale may be useful for developing assessments and interventions to improve patient satisfaction with ER nursing.
The Clinical Effects of Type 2 Diabetes Patient Management Using Digital Healthcare Technology: A Systematic Review and Meta-Analysis
Authors: Kim Ji-eun , Park Tae-shin , Kim Kwang Joon
Published: March 2022

The disease control rate is very low (at less than 30%) for diabetes. The use of digital healthcare technology is increasing recently for continuous management in daily life. In this study, a meta-analysis was conducted to evaluate the clinical effects of digital healthcare technology for patients with type 2 diabetes management. For a review of the literature, databases such as PubMed, Embase, and Cochrane Library were searched using Medical Subject Heading (MeSH) terms published up to 9 August 2021. As a result, 2354 articles were identified, and 12 randomized controlled trial articles were finally included. Digital healthcare technology combined management for type 2 diabetes significantly decreased HbA1c (p < 0.00001, standardized mean difference (SMD) = −0.49) and marginally decreased triglyceride, compared with usual care (p = 0.06, SMD = −0.18). However, it did not significantly affect BMI (p = 0.20, SMD = −0.47), total cholesterol (p = 0.13, SMD = −0.19), HLD-C (p = 0.89, SMD = −0.01), LDL-C (p = 0.95, SMD = −0.01), systolic BP (p = 0.83, SMD = 0.03), or diastolic BP (p = 0.23, SMD = 0.65), compared with usual care. These results indicate that digital healthcare technology can improve HbA1c and triglyceride levels of type 2 diabetes patients. Further well-designed randomized controlled clinical trials are needed to confirm the clinical effect of digital healthcare technology.
Commercial Potato Cultivars Exhibit Distinct Susceptibility to the Root Lesion Nematode Pratylenchus penetrans
Authors: Figueiredo Joana , Vieira Paulo , Abrantes Isabel , Esteves Ivânia
Published: March 2022

The root lesion nematode Pratylenchus penetrans is an important plant-parasitic nematode of potato. In this study, the susceptibility of commercial potato cultivars to P. penetrans was assessed. Nematode penetration was evaluated in cultivars Agria, Camel, Kennebec, Laura, Royata, and Stemster at 1, 3, 7, and 15 days after inoculation (DAI) with 750 nematodes/plant, and an egression assay at 3 DAI with 1000 nematodes/plant. Reproduction assays of cultivars Agata, Agria, Camel, Désirée, Dirosso, Kennebec, Laura, Picasso, Royata, and Stemster were performed in 2 L pots inoculated with four P. penetrans/g soil and quantified at 60 DAI. Tenue or moderate root cell browning to advanced necrotic areas were observed after nematode penetration, and the number of nematodes/g of root gradually increased with time of infection. A lower number of deposited eggs and nematodes were observed within the roots of cultivar Laura in all assays comparatively to other cultivars. The susceptibility index (SI) was significantly lower in cultivar Laura (0.4–0.6), followed by cultivars Camel and Picasso (0.8–0.9). All remaining cultivars showed SI values above 1. Although the potato susceptibility to the nematode varied among cultivars, no differences on the average number or weight of tubers produced by each plant of inoculated versus non-inoculated plants were detected. Our data reveals that these cultivars have a distinct ability to support the reproduction of P. penetrans.
The Role of Perceived Social Support and Stress in the Relationship between Hope and Depression among Chinese Shadow Education Tutors: A Serial Mediation Model
Authors: Zhang Mohan , Wu Yunpeng , Ji Chengjun , Wu Jianfen
Published: March 2022

The association between hope and depression has been studied, leaving the underlying mechanism of how hope might predict depression unexplored. With a cross-sectional design, this study investigated two possible mediating factors in the relationship between hope and depression among Chinese shadow education tutors, who confront a high turnover rate and are at high risk for depression. Altogether, 221 tutors participated in the survey, and reported their dispositional hope, perceived social support (PSS), perceived stress (PS), and depression. Results indicated that both PSS and PS mediated the relationship between hope and depression. Results also supported the hypothesized serial mediating effect. In other words, hope as a positive disposition may promote PSS, which can mitigate PS. The reduced PS, in turn, alleviates depression. This finding not only shed light on the independent and accumulative mediating effects of PSS and PS, but also has implications for preventive interventions among Chinese shadow education tutors experiencing the enormous pressure of instability. This serial mediation model should be confirmed by further longitudinal study.
The Short- and Long-Term Impact of COVID-19 Lockdown on Child Maltreatment
Authors: Long Mengqing , Huang Jia , Peng Yishun , Mai Yawen , Yuan Xian , Yang Xinhua
Published: March 2022

Background: The COVID-19 pandemic has brought a new threat to child health and safety. Some studies suggest that social isolation and economic stress have exacerbated child abuse and neglect, whereas other studies argue that orders to stay at home are likely to promote parent–child relationships during this stressful time. Due to a lack of prospective studies including before–during–after lockdown assessments, the impacts of lockdown measures on child maltreatment are unclear. Methods: This study retrospectively investigated child maltreatment of 2821 Chinese children and adolescents from 12 to 18 (female, 59%) before, during and after lockdown, and identified risk factors. Potential predictors including socio-economic and individual mental health status were collected. Results: During Chinese lockdown, children and adolescents reported that the proportions of decrease (range 18–47.5%) in emotional abuse and neglect, physical abuse and neglect, sexual abuse, and witnessing domestic violence were greater than that of increase (range 5.1–9.1%). Compared with before lockdown (1.6%), the prevalence of sexual abuse significantly increased 8 months (2.9%) after the lifting of lockdown (p = 0.002). Being male, suffering from depression, state anhedonia, and experiencing psychotic symptoms at baseline were associated with increased sexual abuse after lockdown. Conclusions: The impact of lockdown on child maltreatment was beneficial in the short-term but detrimental in the long-term in China.
Total Play Time Needed for Preschoolers to Reach Recommended Amount of Non-Sedentary Activity
Authors: Koepp Andrew E. , Gershoff Elizabeth T. , Castelli Darla M. , Bryan Amy E.
Published: March 2022

Health guidelines suggest that caregivers provide preschoolers with opportunities to be physically active for 3 h per day (roughly 15 min per waking hour), but because children are not continuously active, it is unclear what amount of time is needed to reach this goal. This naturalistic study enrolled 67 children (M = 4.5 years, 46% female) who wore accelerometers to measure their activity during indoor and outdoor free -play (N = 315,061 s). An hour of indoor play was insufficient for most children to reach 15 min of physical activity. When outside, most children reached 15 min of physical activity after slightly more than 30 min. Children engaged in outdoor activity sporadically (1.7 starts/stops per minute). Most physical activity occurred in bouts shorter than 20 s. Indoor free-play does not, on its own, provide sufficient opportunity for preschoolers to engage in physical activity consistent with health guidelines. As a result, outdoor play for at least 30 min at a time has a key role in meeting these guidelines.
Predictors for Early and Late Death in Adult Patients with COVID-19: A Cohort Study
Authors: Yen Yung-Feng , Chan Shang-Yih , Chen Chu-Chieh , Deng Chung-Yeh
Published: March 2022

The timing of death in patients with coronavirus disease 2019 (COVID-19) varied by their comorbidities and severity of illness. However, few studies have determined predictors of mortality with respect to the timing of death in infectious patients. This cohort study aimed to identify the factors associated with early and late death in hospitalized COVID-19 patients. From 14 May to 31 July 2021, this study consecutively recruited laboratory-confirmed COVID-19 patients admitted to Taipei City Hospital. All patients with COVID-19 were followed up until death or discharge from the hospital or till 13 August 2021. Mortality in such patients was categorized as early death (death within the first two weeks of hospitalization) or late death (mortality later than two weeks after hospitalization), based on the timing of death. Multinomial logistic regression was used to determine the factors associated with early and late death among such patients. Of 831 recruited patients, the overall mean age was 59.3 years, and 12.2% died during hospitalization. Of the 101 deceased, 66 (65.3%) and 35 (34.7%) died early and late, respectively. After adjusting for demographics and comorbidities, independent predictors for early death included age ≥ 65 years (adjusted odds ratio (AOR) = 5.27; 95% confidence interval (CI): 2.88–9.65), heart failure (AOR = 10.32; 95% CI: 2.28–46.65), and end-stage renal disease (AOR = 11.97; 95% CI: 3.53–40.55). This study found that two thirds of COVID-19 deaths occurred within two weeks of hospitalization. It suggests that hospitalized patients with COVID-19 should be treated carefully and monitored closely for the progression of clinical conditions during treatment, particularly in older patients and in those with comorbidities.
The Digital Divide of Know-How and Use of Digital Technologies in Higher Education: The Case of a College in Latin America in the COVID-19 Era
Authors: García-Martín Judit , García-Sánchez Jesús-Nicasio
Published: March 2022

To determine whether or not digital inequalities exist, the frequency, duration, satisfaction, importance, and perceived competence of eighteen groups of digital tools during the COVID-19 pandemic confinement were examined. An online survey was administered to 2882 Latin American university students (49% female; M = 21.3 years). The following items are checked: (1) increased digital inequalities during the pandemic; (2) adequate reliability and validity of the Digital Technology Survey (DTS) instrument; (3) patterns of digital inequalities to the detriment of men, lower strata and unemployed people; and (4) evidence that the importance of digital activities as a causal factor on satisfaction with such digital activities as an outcome is mediated by the purpose of use and communication recipients, but not by strata or employment status, nor moderated by gender. The results are discussed in the light of previous studies, the limitations of the study and future perspectives.
The Predictors of Psychological Well-Being in Lithuanian Adolescents after the Second Prolonged Lockdown Due to COVID-19 Pandemic
Authors: Jusienė Roma , Breidokienė Rima , Sabaliauskas Stanislav , Mieziene Brigita , Emeljanovas Arunas
Published: March 2022

Recent research highlights the impact of prolonged pandemics and lockdown on the mental health of youngsters. The second wave of COVID-19 brought an increase in mental health problems among young people. Therefore, this study aims to analyze the main factors arising from intra-individual, inter-individual, and environmental contexts that predict good psychological well-being in a group of adolescents after a second prolonged period of social restrictions and distance education. The study included 1483 school students from 11 to 19 years old. The survey assessed self-reported students’ psychological well-being (WHO-5 index), physical activity, sedentary behavior, school social capital, communication with peers and relationships with parents, existing emotional and behavioral problems. The results indicated that 58% of adolescents were of good psychological well-being in spring 2021, after half a year in lockdown. Almost 19% of adolescents had depression risk. The study revealed that during a period of prolonged isolation, male gender, better relationships between young people and their parents, the absence of serious emotional and behavioral problems, less sedentary behavior, and higher school social capital were found to be significant factors predicting adolescents’ psychological well-being. Lower physical activity is an important contributor to students’ poor well-being. Finally, the lack of face-to-face communication with peers was revealed as a specific factor in predicting adolescents with depression risk.
Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia
Authors: Alkhodary Ahmed Abdelmajed , Aljunid Syed Mohamed , Ismail Aniza , Nur Amrizal Muhammad , Shahar Suzana
Published: March 2022

Background: Cognitive frailty (CF) as a potential risk factor for dementia, functional disability, poor quality of life, and mortality. The aim of this study was to explore the health care-related utilization and out-of-pocket (OOP) expenditures, sociodemographic characteristics, and comorbidities among elderly Malaysians with CF. Methods: A cross-sectional study targeting elderly Malaysian aged ≥65 years was conducted. The study included all participants of the fourth phase of the Malaysian representative Long-Term-Research-Grant-Scheme Towards-Useful-Aging (LRGS-TUA) community-based study. A structured and validated interview questionnaire was used. Results: In total, 1006 elderly were interviewed, with a 66.18% response rate. Only 730 respondents met the inclusion criteria. Of the eligible respondents, the CF prevalence was 4.5%. Around 60.6% of the participants with CF had utilized outpatient care at government clinics within the past 6 months. The estimated mean total OOP payments for CF during the past 6 months was 84 Malaysian Ringgit (RM) (SD 96.0). Conclusions: CF among elderly Malaysians is within the internationally recognized range of prevalence. The OOP payments for seeking health care among CF elderly are not different from that of other elderly categories. There is a high possibility of underutilization of the health care services of CF cases while they are still needy.
Using Coordinated Visual and Verbal Cues in Complex Multimedia Materials to Improve Tactical Learning in Soccer
Authors: Mezghanni Nourhen , Rekik Ghazi , Crowley-McHattan Zachary J. , Belkhir Yosra , Ayed Rayda Ben , Hadadi Atyh , Alzahrani Turki Mohsen , Kuo Cheng-Deng , Chen Yung-Sheng
Published: March 2022

This study aimed to explore whether the use of coordinated visual and verbal cues in narrated diagrams would support novices in learning soccer scenes. Eighty female university students (Mage = 20 years, SD = 1.2) in physical education (PE) were randomly exposed to four multimedia material versions: (a) simple without cues, (b) simple with cues, (c) complex without cues, and (d) complex with cues. In the non-cued versions, students learned the evolution of soccer scenes via arrow-based diagrams accompanied by oral explanations. In the cued versions, game actions in narrations were spoken with a louder accent (verbal cueing), while at the same time, the corresponding arrows turned red in diagrams (visual cueing). After studying one of the four versions, participants were asked to complete immediate and delayed recall–reconstruction tests, and to indicate their attitudes towards instructional materials. The results demonstrate the instructional benefits of using coordinated dual-modality cues in the complex multimedia material, in terms of immediate (p = 0.03, d = 0.53) and delayed (p = 0.02, d = 0.85) recall performances. The findings encourage soccer teachers to verbalize game actions with a louder accent, while simultaneously coloring the corresponding arrows in the diagram when explaining complex game situations for novices.
Assessment of CVD Risk Factors in Secondary Prevention after Ischemic Stroke Using the ICF
Authors: Lucki Mateusz , Chlebuś Ewa , Wareńczak Agnieszka , Daroszewski Przemysław , Lisiński Przemysław
Published: March 2022

Background: Patients after undergoing ischemic stroke have a high risk of further cardiovascular disease (CVD) incidents. Monitoring risk factors is critical to prevent the recurrence of CVD. Objective: The aim of the study was to determine differences in the incidence of risk factors for CVD in a post-ischemic stroke patient group (SG) compared to the control group, which had not undergone ischemic stroke (CG), and to characterize them using the ICF (International Classification of Functioning, Disability and Health) classification system. Materials and Methods: The incidence of risk factors for recurrent CVD events were retrospectively analyzed in 55 patients in SG and 55 patients in CG. The results were translated into categories from the ICF classification system. Results: Atrial fibrillation (p = 0.013), carotid artery stenosis > 50% (p < 0.001), LDL > 71 mg/dL (p < 0.001), heart rate > 80/min (p = 0.007), taking NOAC (p = 0.008) and NSAIDs (p < 0.001) as well as nicotinism (p = 0.001) were significantly more common in SG compared to CG. The value of the distribution of the total incidence of CVD risk factors were observed to be higher for SG than for CG. In SG, both for males (p < 0.001) and females (p < 0.001) more risk factors for recurrent CVD incidents were observed compared to CG. Conclusions: Patients in SG differ in the occurrence of risk factors for CVD event compared to CG. The use of a single tool, such as the ICF assessment sheet, can be useful in assessing and analyzing risk factors for recurrent CVD events. This may help to reduce the risk of subsequent CVD events in secondary prevention.
Backward Walking Training Impacts Positive Effect on Improving Walking Capacity after Stroke: A Meta-Analysis
Authors: Wen Hongwei , Wang Min
Published: March 2022

Objective: The meta-analysis aimed to investigate the potential effect of backward walking training (BWT) on walking function improvement among stroke patients. Data sources: Eligible studies were systematically searched in PubMed, Embase, Web of Science, and Cochrane Library. Methods: Heterogeneity among enrolled studies was assessed. Weighted mean difference (WMD) with its 95% confidence interval (CI) was used to pool the outcomes. Results: Seven articles were included. BWT significantly improved motor functions of stroke patients including 10-meter walk test (WMD (95% CI) = 0.11 (0.01, 0.21) meters/second; p = 0.03); cadence (WMD (95% CI) = 4.00 (0.99, 7.02) step/minute; p < 0.01); Berg balance scale (WMD (95% CI) = 4.38 (2.60, 6.15); p < 0.01); paretic step length (WMD (95% CI) = 5.32 (1.97, 8.67) cm; p < 0.01); and stride length (WMD (95% CI) = 6.61 (0.70, 12.51) cm; p = 0.03) as compared with control group. Conclusion: Our study revealed that BWT had a positive influence on walking function improvement among patients after stroke.
Voice Endorsement and Employee Safety Voice Behavior in Construction Projects: The Mediating Role of Leader-Member Exchange
Authors: Sun Yunfeng , Yang Hao , Qian Chongyang , Jiang Yifeng , Luo Xiaowei , Wu Xiang
Published: March 2022

Employee safety voice refers to publishing opinions and suggestions related to workplace safety issues. In recent years, it has gradually become a hot topic in the field of organizational safety management research. Voice endorsement is the leader’s positive feedback to employees, and it is a necessary condition and key link for employees to achieve the purpose of voicing. Although there are many types of research on employee safety voice behavior and voice endorsement, few studies have explored the relationship between the two. Therefore, through a paired questionnaire survey of 214 leaders and 344 employees in construction projects, drawing on social exchange theory, using leader-member exchange (LMX) as a mediating variable, we discuss the mechanism of voice endorsement on employee safety voice behavior. The results show that in construction projects, voice endorsement negatively affects employee safety voice behavior and LMX, and LMX positively affects employee safety voice behavior. LMX has a mediating role in the relationship between voice endorsement and employee safety voice behavior. The results of this study can provide useful guidance for improving employee safety voice behavior management.
Partnership for International Development: Finland-Nigeria Conference on Climate, Food, Health and Entrepreneurship
Authors: Raheem Dele , Oluwole Oluwatoyin B. , Faven Leena , Orji Frank A. , Junttila Mikko , Rainosalo Egidija , Kosoko Sulaimon B. , Olukosi Adeola , Vainio Seppo , Olapade Abiodun A. , Okoh Michael P. , Oyeku Oyedele M.
Published: March 2022

A joint collaboration between the Arctic Centre of the University of Lapland, Finland and the Federal Institute of Industrial Research, Oshodi, Lagos, Nigeria was organised as a hybrid conference on several topics that are related to climate, food, health and entrepreneurship. The utilisation of natural resources in both regions is an important theme in meeting the sustainable development goals agenda. The topics discussed were multidisciplinary, they include Nigerian indigenous foods, bioeconomy, circular economy, nutrition, health, innovation and entrepreneurship under four themes (Climate, Food, Health and Entrepreneurship). There were dignitaries from Finland and Nigeria. The presenters are researchers from Nigerian universities (University of Ibadan, University of Abuja and Eko university, Lagos), Nigerian Federal Institute of Industrial research centre and from the Finnish side we have the university of Lapland, Rovaniemi, University of Oulu, Oulu and the Centria University of Applied Sciences, Kokkola. The topics discussed will serve as training materials for students and learners, the discussion focussed on research opportunities for institutions in both countries. The experts from both countries will continue to dialogue on the possibility of promoting common topics as research agenda in these important areas with the possibilities of creating more jobs.
Factors Associated with Refraining from Purchasing Foods Produced in Affected Areas after the Fukushima Daiichi Nuclear Power Station Accident
Authors: Yamaguchi Takumi , Horiguchi Itsuko , Kunugita Naoki
Published: March 2022

After the accident at the Fukushima Daiichi Nuclear Power Station, food products from the areas affected by the accident suffered reputational damage worldwide. Therefore, the present study aimed to identify the factors associated with people refraining from purchasing foods produced in affected areas to avoid radioactive materials. The study also aimed to clarify the time trends for the avoidance of foods produced in Fukushima Prefecture. We used data from “A survey on consumer awareness of reputational damages” conducted by the Japanese Consumers Customer Agency and implemented statistical analysis. Even if the year since the accident differed, “living with children”, “knowing detailed information about food inspections”, and “not being able to accept radiation risk even if the level is below the standard” were commonly associated. Not only did this study reveal that some people’s risk perceptions are fixed even when new knowledge is provided, but it also suggests that the implementation of food inspection can promote reputational damage. Additionally, the avoidance of Fukushima food products was found to decrease as time passed after the Fukushima accident. The results of this study may help develop countermeasures against reputational damage to food products after future nuclear disasters.
Effectiveness of Mantra-Based Meditation on Mental Health: A Systematic Review and Meta-Analysis
Authors: Álvarez-Pérez Yolanda , Rivero-Santana Amado , Perestelo-Pérez Lilisbeth , Duarte-Díaz Andrea , Ramos-García Vanesa , Toledo-Chávarri Ana , Torres-Castaño Alezandra , León-Salas Beatriz , Infante-Ventura Diego , González-Hernández Nerea , Rodríguez-Rodríguez Leticia , Serrano-Aguilar Pedro
Published: March 2022

Background: Meditation is defined as a form of cognitive training that aims to improve attentional and emotional self-regulation. This systematic review aims to evaluate the available scientific evidence on the effectiveness and safety of mantra-based meditation techniques (MBM), in comparison to passive or active controls, or other active treatment, for the management of mental health symptoms. Methods: MEDLINE, EMBASE, Cochrane Library, and PsycINFO databases were consulted up to April 2021. Randomised controlled trials regarding meditation techniques mainly based on the repetition of mantras, such as transcendental meditation or others, were included. Results: MBM, compared to control conditions, was found to produce significant small-to-moderate effect sizes in the reduction of anxiety (g = −0.46, IC95%: −0.60, −0.32; I2 = 33%), depression (g = −0.33, 95% CI: −0.48, −0.19; I2 = 12%), stress (g = −0.45, 95% CI: −0.65, −0.24; I2 = 46%), post-traumatic stress (g = −0.59, 95% CI: −0.79, −0.38; I2 = 0%), and mental health-related quality of life (g = 0.32, 95% CI: 0.15, 0.49; I2 = 0%). Conclusions: MBM appears to produce small-to-moderate significant reductions in mental health; however, this evidence is weakened by the risk of study bias and the paucity of studies with psychiatric samples and long-term follow-up.