bluuebunny/crossref_metadata_2025 huggingface dataset:
Education of A Linguistic Personality in the Context National Culture of the Sakha People
Authors:   Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky of Ministry of Health of the Russian Federation, Avdeeva Elena A. , Kurilkina Valentina N. ,   North-Eastern Federal University named after M.K. Ammosov
Published: September 2022

The article discusses the philosophical and pedagogical foundations for creating a model of a linguistic personality based on the national culture of the Sakha people (in the plural — Sakhalar), which means “white”, “sunny” in the Yakut language. The sun is one of the main symbols of national culture, depicted on the republican flag as a white circle. The Sakha people have a rich system of ethnic education of the younger generation, built with the help of their national mythological, cultural, religious traditions, language and culture. However, global changes in the education of the Sakha people, the emergence of information and digital technologies, the emerging threat of the disappearance of the native language pose new questions for modern pedagogical science related to understanding the role of the native language and culture in the education and upbringing of the younger generation. The article substantiates the necessity of considering the peculiarities of educating a schoolchild’s linguistic personality in the system of his native language. Because it is in the semantics of the national language as part of the culture of the people that the holistic ethical picture of the world and the universe itself are encoded. The educated linguistic personality makes it possible for young person to have reliable immunity from the destruction of national traditions and cultural heritage, false and primitive norms of behavior and social temptations imposed on society through the media and a distorted system of social values.
Effects of black tea tooth staining previously to 35% hydrogen peroxide bleaching
Authors: Palandi Samuel da Silva , Kury Matheus , Picolo Mayara Zaghi Dal , Esteban Florez Fernando Luis , Cavalli Vanessa
Published: September 2022

Aim: To determine if the artificial staining with black tea (BT) influences the enamel microhardness before in-office bleaching and if BT staining is necessary to evaluate the efficacy of bleaching with 35% hydrogen peroxide Methods: Enamel/dentin blocks were randomized into groups according to the staining protocol (n=5/group): (CO) control – maintained in artificial saliva solution (AS); (BT4) immersed in black tea solution for 4 h; (BT24) immersed in black tea solution for 24 h. After the staining protocols, all specimens were kept in AS for one week, followed by bleaching (three sessions of HP application for 40 min). Knoop surface microhardness (kgF/mm2) was determined at baseline (T0), after staining (T1), after 7 days of storage in AS (T2), and after bleaching (T3). The color (ΔE00) and coordinate changes (ΔL, Δa, Δb) were measured using a digital spectrophotometer at T0 and T3. Data were submitted to one-way (ΔE00, ΔL, Δa, Δb) or two-way ANOVA repeated measures (kgF/mm2) and Tukey’s test (a=5%). Results: The staining protocols (BT4 and BT24) promoted significantly lower microhardness (T1 and T2, p<0.05) than CO, whereas CO was the only group to maintain microhardness values over time. Bleaching promoted perceptible ΔE00 without a significant difference among the groups regardless of the staining protocol (p=0.122). CO and BT4 showed no differences in terms of ΔL and Δa (p>0.05), but BT4 displayed a higher Δb than CO. Conclusion: The artificial staining with BT negatively affected the enamel surface microhardness and was not essential to evaluate the efficacy of 35% hydrogen peroxide bleaching.
Cytotoxic test of different solvents of soursop (Annona muricata) leaf extract against HSC-3 cell line
Authors: Bhanuwati Areta Vania , Pakpahan Alfred
Published: September 2022

Background: Soursop (Annona muricata) leaves have been researched extensively and found to have anticancer properties. The use of soursop as an anticancer treatment is increasingly popular due to its selective cytotoxic activity by acetogenins. The polarity of the extract solvent contributes to the biological activity of the plant, namely cytotoxicity. Purpose: To determine the cytotoxicity of A. muricata leaf extract with ethanol, ethyl acetate and hexane fractions against human oral squamous carcinoma (HSC-3) cell lines. Methods: This experimental laboratory study consisted of twenty four treatment groups tested against the HSC-3 cell line. The ethanol, ethyl acetate and hexane fractions of A. muricata leaves were administered to seven different concentrations, namely 0.3 μg/mL, 3 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL, 150 μg/mL and 300 μg/mL. The control group consisted of three groups: negative control, solvent control and positive control. The percentage of cell viability was calculated by absorbent enzyme-linked immunosorbent assay (ELISA) reader. The cytotoxicity of A. muricata leaf extract against HSC-3 cells was determined by cell counting kit-8 (CCK-8) assay and expressed by IC50 value. The results were analysed using one-way analysis of variance (ANOVA) followed by Tukey’s honestly significant difference (HSD). Results: The results show that the leaf extracts of A. muricata are moderately cytotoxic to HSC-3 cells. The highest cytotoxic activity was found in the ethyl acetate extract with an IC50 value of 76.66 μg/mL – making it the best solvent – then hexane (IC50: 84.14 μg), then ethanol (IC50: 101.32 μg/mL). Statistical analysis using one-way ANOVA and Tukey’s HSD is considered significant p < 0.001. Conclusion: Ethanol, ethyl acetate and hexane fractions of A. muricata leaf extract are moderately cytotoxic, with IC50 values in the range of 21–200 μg/mL.
Immunohistochemical differential expression of p16 proteins in follicular type and plexiform type ameloblastoma
Authors: Widodo Haris Budi , Saptiwulan Anung , Hirawan Helmi , Prihastuti Christiana Cahyani , Wardana Tirta
Published: September 2022

Background: Differences in histopathological features that describe the growth mechanism and biological behaviour of follicular and plexiform ameloblastomas are associated with benign, aggressive and destructive tumour markers. p16 has inhibitory interactions between cyclin D and CDK 4/6 to block the cell cycle and alterations related to severity. Purpose: This study intends to evaluate and determine differential expressions of p16 protein in follicular and plexiform ameloblastomas. Methods: This is a descriptive analytics study. A total of 21 specimens consisting of follicular and plexiform ameloblastomas and healthy gingiva tissues as the negative control were examined using the immunohistochemistry assay. The analysis of p16 protein expression was interpreted by immunoreactive scoring. Statistical analysis was conducted using SPSS software with the Mann–Whitney test. A p-value <0.05 shows the significance of the change in expression. Results: An increased expression of p16 protein was found in the follicular ameloblastoma type (2.13 ± 1.808) and the plexiform type (4.44 ± 2.506) in comparison to the negative control group (0 ± 0). The increase of p16 expression in the follicular and plexiform ameloblastomas was significant compared to the negative control group (p-value <0.05); however, there was no significant difference between either type of ameloblastoma (p-value >0.05). Conclusion: The highest intensity of p16 protein expression was found in the plexiform type, even though it was not significantly different from the follicular type ameloblastoma.
Mapping of health care facilities, dental visits and oral health problems in Indonesia to prevent COVID-19 transmission
Authors: Lestari Ayu Asri , Adiatman Melissa , Darwita Risqa Rina
Published: September 2022

Background: One of the goals of Indonesia’s participation in sustainable development goals is to improve its health state. Efforts to achieve health improvement are increasing the availability of health care facilities so people can easily access and get treatment for dental and oral health. As we know, the first case of COVID-19 in Indonesia was found in March 2020 and all cases were spread over 34 provinces. During this pandemic situation, health care facilities and some dental treatments generating aerosols are one of the environments that can potentially transmit COVID-19 to the community. Dentists have the riskiest job because they must be less than two meters from patients. Purpose: This study aimed to evaluate the distribution of health care facilities, dental visits and oral health problems to prevent increased exposure to COVID-19 by using a geographic information system to explore the distribution of regional data. Methods: This study is a secondary data analysis and used data from Indonesia Basic Health Research 2018 and Health Facility Research 2019. Data of health care facilities, dental visits and oral health problems were tabulated using MS Excel version 16.45. Spatial mapping was done using Quantum Geographic Information System Desktop version 3.18.3 based on open-source software. Results: Java Island has the highest distribution of health care facilities and receives treatment from the dentist. COVID-19 reached a peak in June–July 2021, and Java Island became the region with the highest incidence rate. Conclusion: The distribution of health care facilities and dental visits was in line with the spread of the COVID-19 virus in 34 provinces. Almost all treatments of oral health problems need a highspeed rotary instrument, which can be a source of transmission of this virus.
Characterisation of stem extracts of various grape varieties obtained after maceration under simulated alcoholic fermentation
Authors: Blackford Marie , Comby Montaine , Dienes-Nagy Ágnes , Zeng Liming , Cléroux Marilyn , Lorenzini Fabrice , Bourdin Gilles , Bach Benoit
Published: September 2022

The removal of stems prior to maceration during red winemaking is generally associated with an improvement in wine quality. However, in recent years, increased interest in the use of stems in winemaking has been observed among winegrowers. Different advantages of this practice have been listed in the literature. In order to better understand their role during winemaking, stems of ten red grape varieties from different winegrowing regions of Switzerland were studied to determine which minerals, acids and polyphenols are extracted under simulated alcoholic fermentation. The composition of the extracts revealed differences between the grape varieties. In addition, the growing conditions and the terroir seem to have an influence on the compounds extracted from the stems, especially the mineral composition such as potassium and copper. Among the extracted polyphenols, phenolic acids and proanthocyanidins were mostly found in the stem extracts, especially caftaric acid, catechin and procyanidin B1. Their concentrations were significant compared to the average values found in wines.
UniStArt: A 12-Month Prospective Observational Study of Body Weight, Dietary Intake, and Physical Activity Levels in Australian First-Year University Students
Authors: Wilson Nina , Villani Anthony , Tan Sze-Yen , Mantzioris Evangeline
Published: September 2022

Background: Students in the United States gain weight significantly during their first year of university, however limited data are available for Australian students. Methods: This 12-month observational study was conducted to monitor monthly body weight and composition, as well as quarterly eating behaviours, dietary intake, physical activity, sedentary behaviours, and basal metabolic rate changes amongst first-year Australian university students. Participants were first-year university students over 18 years. Results: Twenty-two first-year university students (5 males and 17 females) completed the study. Female students gained weight significantly at two, three, and four-months (+0.9 kg; +1.5 kg; +1.1 kg, p <0.05). Female waist circumference (2.5 cm increase at three-months, p = 0.012), and body fat also increased (+0.9%, p = 0.026 at three-months). Intakes of sugar, saturated fat (both >10% of total energy), and sodium exceeded recommended levels (>2000 mg) at 12-months. Greater sedentary behaviours were observed amongst male students throughout the study (p <0.05). Conclusions: Female students are at risk of unfavourable changes in body composition during the first year of university, while males are at risk of increased sedentary behaviours. High intakes of saturated fat, sugars, and sodium warrant future interventions in such a vulnerable group.
Physician’s Hesitancy in Treating COVID-19 Patients and Its Associated Occupational Risk Factors in Indonesia: An Online Cross-Sectional Survey
Authors: Soemarko Dewi Sumaryani , Kekalih Aria , Syam Ari Fahrial , Yunihastuti Evy , Herikurniawan Herikurniawan , Yosia Mikhael
Published: September 2022

This study is a cross-sectional survey involving physicians around Indonesia aimed to explore physician hesitancy to treat COVID-19 patients after experiencing COVID-19 infection coupled with associated occupational risk factors. The questionnaire was distributed via contact information from the Indonesian Physician Association database. Out of 383 participants, 25.6% suffered from moderate symptoms of COVID-19 and 2.9% were admitted for critical care. Hesitancy to treat suspected, probable, or confirmed COVID-19 patients was found in 20.3% of physicians. A higher hesitancy rate was found in older physicians and those with less experience in treating COVID-19 patients. Specialist trainees and those who work in public hospitals were physicians with the lowest hesitancy in treating COVID-19 patients. There is a significant hesitancy in treating COVID-19 patients among physicians who have suffered from COVID-19 which calls for further action by management and policy makers.
Impact of Information Technology in the Hiring Process of People
Authors: Azam Muhammad , Nouman Muhammad , Rehman Gill Ahsan
Published: September 2022

As we are aware Information Technology had its cutting-edge lifestyle from the overdue sixties of the remaining century whilst the Arpanet become introduced, funded with the aid of using the branch of protection of the USA. After that, the IT enterprise has come a protracted manner to its cutting-edge form in which its miles gambling a dominant function in each sphere of life. It has made innovative modifications in facts amassing and dissemination and worldwide communication. It is growing into a surely paperless painting environment. Also, we can now ship a message very without difficulty to everywhere withinside the international in seconds. From a schooling factor of view, we can have a digital elegance in which the teacher ought to take a seat down in any part of the arena and his college students scattered in all exceptional elements of the arena via video convention with the presentation of look at substances in addition to query and solution sessions. A health practitioner now sitting in any part of the arena ought to carry out a surgical procedure in which the affected person is mendacity in some other part of the arena. These work examples display where we stand these days compared to what has become 1/2 of a century back. But as we recognize, nothing on this international is only correct as the whole thing has a darkish side. In this paper, we might speak about the deserves and demerits of enforcing IT globally and in which we are heading withinside the future.
Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella typhimurium
Authors: Gildea Logan , Ayariga Joseph , Xu Junhuan , Villafane Robert , Boakai Robertson , Samuel-Foo Michelle , Ajayi Olufemi
Published: September 2022

New generation antibiotics are needed to combat the development of resistance to antimicrobials. One of the most promising new classes of antibiotics is cannabidiol (CBD). It is a non-toxic and low-resistance chemical that can be used to treat bacterial infections. The antibacterial activity of Cannabis sativa L. byproducts, specifically CBD, has been of growing interest in the field of novel therapeutics. As research continues to define and characterize the antibacterial activity that CBD possesses against a wide variety of bacterial species it is important to examine potential interaction between CBD and common therapeutics such as broad-spectrum antibiotics. Here, we show that CBD-antibiotic co-therapy can effectively fight S. typhimurium via membrane integrity disruption. This research serves to examine the potential synergy between CBD and three broad-spectrum antibiotics for potential antibiotic-CBD co-therapy. In this study, we reveal that Salmonella typhimurium (S. typhimurium) growth is inhibited at very low dosages of CBD-antibiotic. This interesting finding demonstrates that CBD and CBD-antibiotic co-therapies are viable novel alternatives to combating Salmonella typhimurium.
A New Look at Physico-Chemical Causes of Changing Climate: Is the Seasonal Variation in Seawater Temperature a Significant Factor in Establishing the Partial Pressure of Carbon Dioxide in the Earth’s Atmosphere?
Authors: Kennedy Ivan R. , Runcie John W. , Zhang Shuo , Ritchie Raymond J.
Published: September 2022

Seasonal oscillations in the partial pressure of carbon dioxide (pCO2) in the Earth’s atmosphere stronger in northern latitudes are assumed to show that terrestrial photosynthesis exceeds respiration in summer reducing the pCO2, but increasing in winter when respiration exceeds photosynthesis. We disagree, proposing that variations in the temperature of the surface mixing zone of seawater also regulate the atmospheric pCO2, thermodynamically. We show that carbonate (CO32-) concentrations will therefore increase in summer with CaCO3 (calcite or aragonite) becoming less soluble, so calcium and carbonate ions are predicted to aggregate more while CO2 concentration falls in warmer seawater, thermodynamically favoring lower atmospheric pCO2. In winter, these physical processes are reversed, redissolving suspended calcite thus increasing carbonate alkalinity; carbonate concentration lessens as bicarbonate and soluble CO2 increase, raising the pCO2 in air. Our numerical computation shows that thermal fluctuations in equilibria favor absorption from air of more than one mole of CO2 per square meter in summer, coinciding with calcite formation maximizing in warmer water, potentially augmenting limestone reefs if there is a trend for increasing temperature . Another assumption we challenge is that upwelling from deeper water is the sole cause of increases in dissolved inorganic carbon (DIC) and alkalinity in surface waters, particularly in the southern hemisphere. Instead, calcite dissolution is favored as water temperature falls near the surface. It is well established that the seasonal summer decline in atmospheric CO2 coincides in fertile seawater with higher rates of biotic calcification and acidity, allowing increased CO2 capture by photosynthesis. However, its reversal in winter is proposed to be also a result of the cyclic dissolution of calcite as temperature falls, facilitated by biogenic respiration now exceeding photosynthesis; this can mutually provide the CO2 needed to convert carbonate ion alkalinity from calcite dissolution with bicarbonate increasing. Physical reasons why this oscillation is more obvious in the northern hemisphere include greater seasonal variations in water temperature (ca. 7.1 oC) being almost twice that in the cooler southern hemisphere (ca. 4.7 oC) and the greater depth of the surface mixing zone of seawater in the southern oceans. Evidence from 13CO2 fluxes between surface seawater and air is also assessed to test this hypothesis but questions remain regarding the regional rates of inorganic precipitation and dissolution of CaCO3 in the mixing zone. In summary, rapid biogenic calcification is favored by summer photosynthesis, but slower abiogenic calcification is more likely in warmer water.
Comparison of geogases in Cenozoic sedimentary environments
Authors: Berberich Gabriele M. , Berberich Martin B.
Published: September 2022

We investigated fault gases (helium, radon, CO2) in two seismically active Cenozoic sedimentary environments: a) Meinweg (in 2015) at a tectonically quiet horst structure in the Lower Rhine Embayment and b) Bodanrück (in 2012; Lake of Constance) at the Molasse Basin and part of the Freiburg–Bonndorf–Bodensee Fault Zone (FBBFZ). Both study areas were selected because recent “GeoBio-Interactions” findings showed, that red wood ants (RWA) are biological indicators of otherwise undetected degassing systems. A total of 817 soil gas samples was analyzed. Currently, Meinweg can be considered “no ants land” due to the very low background-level geogas concentrations. Thus, anomalies (Rn-CO2) weakly trending in NE-SW extension direction emerged. This could probably indicate the onset of (re)activation of the NE-SW trending (Variscan) structures or the development of new fractures as an aftershock process of the 1992 Roermond earthquake that occurred about 15 km to the west. Results at Bodanrück (3 RWA clusters and two RWA-free corridors) revealed degassing patterns in NW-SE and NNE-SSW directions in the clusters corresponding to re-activated and recent strike-slip fault systems. No gas anomalies were found in RWA-free corridors. The RWA nest distribution was shown to be a valuable tool for identifying areas of even actively degassing spotty anomalies caused by macro- and microscale brittle deformation masked by sediment cover.
Profile of Service Use and Barriers to Access among Brazilian Children and Adolescents with Autism Spectrum Disorders
Authors: Araripe Beatriz Lobo , Montiel-Nava Cecilia , Bordini Daniela , Cunha Graccielle R. , Garrido Gabriela , Cukier Sebastián , Garcia Ricardo , Rosoli Analia , Valdez Daniel , Caetano Sheila C. , Rattazzi Alexia , Paula Cristiane Silvestre
Published: September 2022

Delayed diagnosis and a lack of adequate care for people with autism spectrum disorder (ASD) are related to worse outcomes and quality of life. This study aimed to identify the profile of service use, barriers to access care, and factors related to those barriers in Brazilian families with children with ASD. A total of 927 families with ASD children (3-17 years) from five Brazilian regions completed an online version of the Caregivers Needs Survey. Results showed that the most used services were behavioral interventions and pharmacotherapy, while the most used professionals were neurologists, nutritionists, speech therapists, psychiatrists, psychologists, and pediatricians. The main barriers included waiting lists, costs, and the absence of services or treatment. Service use varied according to age, the region of residence, the type of health care system used, and the parents/caregivers' education. Access to behavioral interventions was more frequent among users of the private system/health insurance and families whose caregivers had higher education. The absence of specialized services/treatments was less frequent among residents of state capitals and families whose caregivers had higher levels of education. This study highlights how families with children/adolescents with ASD in Brazil face significant barriers to access care related to sociodemographic factors.
Collatz Dynamics is Partitioned by Residue Class Regularly
Authors: Ren Wei
Published: September 2022

We propose Reduced Collatz Conjecture that is equivalent to Collatz Conjecture, which states that every positive integer can return to an integer less than it, instead of 1. Reduced Collatz Conjecture should be easier because some properties are presented in reduced dynamics, rather than in original dynamics (e.g., ratio and period). Reduced dynamics is a computation sequence from starting integer to the first integer less than it, and original dynamics is a computation sequence from starting integer to 1. Reduced dynamics is a component of original dynamics. We denote dynamics of x as a sequence of either computations in terms of ``I'' that represents (3*x+1)/2 and ``O'' that represents x/2. Here 3*x+1 and x/2 are combined together, because 3*x+1 is always even and followed by x/2. We formally prove that all positive integers are partitioned into two halves and either presents ``I'' or ``O'' in next ongoing computation. More specifically, (1) if any positive integer x that is i module $2^t$ (i is an odd integer) is given, then the first t computations (each one is either ``I'' or ``O'' corresponding to whether current integer is odd or even) will be identical with that of i. (2) If current integer after t computations (in terms of ``I'' or ``O'') is less than x, then reduced dynamics of x is available. Otherwise, the residue class of x (namely, i module $2^t$) can be partitioned into two halves (namely, i module $2^{t+1}$ and $i+2^t$ module $2^{t+1}$), and either half presents ``I'' or ``O'' in intermediately forthcoming (t+1)-th computation.
Existence of Common Fixed Points of Generalized ∆-Implicit Locally Contractive Mappings on Closed Ball in Multiplicative G-metric Spaces with Applications
Authors: Rasham Tahair , Nazam Muhammad , Aydi Hassen , Agarwal Ravi P.
Published: September 2022

In this paper, we introduced a generalized ∆-implicit locally contractive condition and give some examples to support it and to show its significance in fixed point theory. We prove that the mappings satisfying generalized ∆-implicit locally contractive condition admits a common fixed point, where, the ordered multiplicative GM−metric space is chosen as underlying space. The obtained fixed point theorems generalize many earlier fixed point theorems on implicit locally contractive mappings. In addition, some nontrivial and interesting examples are provided to support our findings. To demonstrate the originality of our new main result, we apply it to show existence of solutions to a system of nonlinear -Volterra type- integral equations.
A Model for Changes in Germination Synchrony and Its Implements to Study Weed Population Dynamics: A Case Study of Brassicaceae
Authors: Maleki Keyvan , Maleki Kourosh , Soltani Elias , Oveisi Mostafa , Gonzalez-Andujar Jose L.
Published: September 2022

In every agricultural setting, weed seeds can be found in every cubic centimeter of soil. Weed seeds, as a valuable trait underlying the fate of weed populations, exhibit differing levels of seed dormancy, ensuring their survival under uncertain conditions. Seed dormancy is considered as an innate mechanism that constrains germination under suitable conditions that would otherwise stimulate germination of non-dormant seeds. This work provides new insight into changes in germination patterns along the dormant to nondormancy continuum in seeds with physiological dormancy. Notable findings are: (1) germination synchrony can act as a new parameter that quantitatively describes dormancy patterns and subsequently weed population dynamics, (2) germination synchrony is dynamic, suggesting that the more dormancy decreases, the more synchrony is obtainable, (3) after-ripening and stratification can function as a synchronizing agent that regulates germination behavior. Brassica napus showed the most synchronous germination with the value of 3.14, while lower level of germination asynchrony was for Sinapis arvensis, with the asynchrony value of 2.25. After-ripening and stratification can act as a synchronizing factor through decreasing asynchrony level and increasing synchrony. Weed establish a firm relationship between dormancy cycling and germination synchrony patterns, ensuring their survival and reproductive strategies. By germinating in synchrony, which is accompanied by cycling mechanisms, weeds have more opportunities to persist. The synchrony model used in the present study predicts germination behavior and synchrony along the dormant to nondormancy continuum in weed seeds with physiological dormancy, suggesting a useful method for quantification of germination strategies and weed population dynamics.
MEJORA EN PROCESOS DE PRODUCCIÓN Y LOGÍSTICA PARA AUMENTAR LA EFICIENCIA EN EL SISTEMA ECONÓMICO DE PEQUEÑAS EMPRESAS MANUFACTURERAS EN COLOMBIA
Authors:   Corporación Universitaria Republicana, DONADO SÁNCHEZ ANGIE MARCELA , MARTIN MOSQUERA MARLON , PÉREZ HUÉRFANO KAREN ANDREA
Published: September 2022

This document describes some of the biggest problems that small manufacturing companies have in Colombia, since these are the ones that generate the most employment and when they close, they cause a high unemployment rate, in addition, through an analysis possible solutions taking into account the production and logistics processes, which are part of the areas that, in these companies, invested or greatly diminish the efficiency and / or economic efficiency of the organization, all this, to avoid the low quality of life of many Colombians who lose their jobs and to increase the economic development of the country in general.
GESTIÓN DE LA PRODUCCIÓN: EVOLUCIÓN Y TENDENCIAS DE INVESTIGACIÓN
Authors:   Universidad Católica Luis Amigó, ALZATE MONTOYA PAOLA MARCELA , HURTADO NIETO BRIGITH DANIELA , GÓMEZ JIMENEZ MARIANA ,   Universidad de Caldas
Published: September 2022

Production management is a progressively relevant issue for the industrial sector, constituted as a business advantage by integrating fundamental decentralized activities for the processes. Organizations manage to optimize their productive resources and be potentially sustainable in a world where competition is increasingly stronger and globalized by incorporating productive management mechanisms. The present study presents a systematic review of the literature on production management, using bibliometric instruments and methods. The Scopus database was implemented for the bibliographic exploration published between 2000 and 2021. The results obtained were processed using the Bibliometric, Software R and Gephi tools. The documents were classified by applying the tree metaphor, which orders them by means of three categories, classical, structural and recent, the latter allow identifying research perspectives, which address issues such as energy efficiency methods applied to processes of production, techniques for distribution systems in production and diffusion techniques. Finally, an agenda for future research is presented.
NORMALIZACIÓN DE TIEMPOS DE CONFECCIÓN EN LA EMPRESA INDUSTRIAS INCA S.A.S (AZZORTI), POR MEDIO DE LA IMPLEMENTACIÓN DE BASES DE DATOS CON TIEMPOS ANALIZADOS POR MEDIO DE MTM
Authors:   Universidad Libre, FUENTES ROJAS EVER ANGEL , FLOREZ ROZO2 GISETTE VIVIANA
Published: September 2022

This article is based on research and development of project Operation standarization through MTM developed in company Industrias Inca S.A. or Azzorti how is more known in 2022, the project aims time standarization. Time manufacturing standarization are the main base to make the launching development of the company and its accuracy is the main guideline for costs assertiveness, however, currently not all times are standarized, even among the same type of clothing. This project was implemented based on DMAIC methodology, first defining the problem, and comparing metrics, then observing and making comparative analysis of competition factors. an analysis and observation were made with different methods of the company and those were validated with MTM´s sequences. The methodology establishment to define each time operation through MTM is based on existent theories so far, combined with manufacturing formulas. Found deviation cost analysis and impact itself are presented, from which goals in the cost deviation indicators a main base with times based on movements MTM is proposed. This article shows how it’s possible to implement an standarized data base and based on theory without need to buy an specialized program, those one could be implemented from the presented scheme and it can be the main element of operational routes and costs of any company, medium or large. The cost impact becomes in the main reason to make the decision to implement it, this methodology could be implemented in large companies that already have a development process, or small and medium companies that will help to them to make an easier and organized process.
Transient L5 Nerve Root Palsy Caused by Subfascial Drain After Lumbar Surgery
Authors: Barile Francesca , Ruffilli Alberto , Viroli Giovanni , Manzetti Marco , Traversari Matteo , Faldini Cesare
Published: September 2022

Case:

We describe the case of a 45-year-old woman who developed a transient L5 deficit after a posterior L4-L5 interbody fusion. A perfusion computed tomography scan ruled out all described causes of postoperative deficit and showed compression of the right L5 root by the subfascial drain. The deficit spontaneously resolved.

Conclusion:

New neurological deficit after spine surgery is a complication that requires a quick diagnostic and therapeutic approach. This particular case is of interest not only because it describes a rarely reported complication (transient neurological motor deficit after posterior fusion) but also because the hypothesized cause has never been described before.
Tranexamic Acid Use During Surgery Associated with Extension of Acute Perioperative Type 1 Myocardial Infarction
Authors: Lynham Rohan , Preissler Sarah , Lightfoot Nicholas J , Coates Joanna
Published: September 2022

Case Presentation:

A 70-year-old women presented to a regional hospital after a fall, resulting in a periprosthetic femoral fracture. Preoperative echocardiogram was ordered to investigate a cardiac murmur, and unexpectedly, a significant regional wall abnormality was found. Further repeat electrocardiograph and troponin blood biomarker analysis demonstrated the patient had suffered an acute type 1 myocardial infarction after admission to the ward, without exhibiting classical ischemic cardiac symptoms. A multidisciplinary decision was made for the patient to proceed to surgery, and at that time, she received tranexamic acid (TXA). Postoperatively, there was notable echocardiographic extension of the infarction, which required transfer to a tertiary center for management with complex coronary artery stenting. The patient once discharged was followed up by cardiology at the 3-month interval.

Conclusion:

The use of TXA in arterial thromboembolic disease requires thorough consideration because it may contribute to further myocardial damage. A patient-specific approach should be adopted with the risk of thrombosis extension being considered.
Surgical Repair of Posttraumatic Hallux Valgus Deformity in a Collegiate Football Player
Authors: Gorica Zylyftar , McFarland Kimberly , Lewis John S. , Schweitzer Karl M. , Vap Alexander R.
Published: September 2022

Case:

We report a rare case of posttraumatic hallux valgus in a collegiate football player after an acute medial collateral ligament tear of the first metatarsophalangeal joint. The patient was treated with a modification of the modified McBride technique, using an all-suture anchor for the medial ligamentous complex repair. There was return to sport at 5 months and a Foot and Ankle Outcome Score of 95% at 10 months.

Conclusion:

A modified McBride procedure further modified with the utilization of an all-suture anchor for the medial ligamentous complex repair can result in correction of deformity, pain-free movement and return to sport.
Osteoanabolic Treatment with Teriparatide for Pathological Stress Transfer After Total Hip Arthroplasty
Authors: Mazzucchelli Ruben A. , Meier Christoph , Wahl Peter
Published: September 2022

Case:

Total hip arthroplasty with an uncemented, tapered, fluted stem was performed in a 79-year-old woman with known osteoporosis to treat an intertrochanteric fracture. Exertional thigh pain and cortical thickening developed at the tip of the stem. The patient was treated with teriparatide for a total of 2 years and became asymptomatic within months. Radiographs showed improved bone quality around the stem of the prosthesis, and dual-energy x-ray absorptiometry scans confirmed remineralization.

Conclusion:

Stem tip pain is a well-known complication of distally engaging arthroplasty implants. Various surgical options have been suggested to address this condition. Teriparatide is known to help prevent fractures and improve bone healing. This successful off-label use might be of interest for the future treatment of this biomechanical complication.
Resection of Posttraumatic Rib Synostoses Resolves Pulmonary Insufficiency
Authors: Mavrommatis Sophia , LaRoque Michael C. , Cole Peter A.
Published: September 2022

Case:

A 30-year-old woman underwent open reduction and internal fixation for multiple segmental rib fractures status post a motor vehicle collision. A year later, the patient presented with extensive intercostal heterotopic ossification associated with multilevel, hemithoracic, rib synostoses compromising her ventilation. The patient subsequently underwent synostoses excision and hardware removal. Pulmonary function tests (PFT), imaging, and patient-reported outcome scores demonstrate resolution of impairment.

Conclusion:

Resection of multilevel, intercostal, rib synostoses provided an effective treatment for pulmonary restrictive disorder secondary to traumatic rib synostosis. This is the first patient with documentation of prereconstructive and postreconstructive PFTs for chest wall synostosis excision.
Chronic Pseudoaneurysm and Anterior Dislocation After Total Hip Arthroplasty Complicated by Arterial Injury
Authors: Crown Taylor J.L. , Sheridan Gerard A. , Bengoa Francisco , Fransen Bas L. , Lawlor David K. , Clarkson Paul W. , Greidanus Nelson V.
Published: September 2022

Case:

A 64-year-old man presented 18 months after total hip arthroplasty complicated by vascular injury with a history of leg pain, inability to mobilize, and progressive chronic leg edema. It is presumed that there was persistent subtle bleeding over time with pseudoaneurysm formation and prosthetic hip dislocation secondary to the mass effect.

Conclusion:

Physicians should consider pseudoaneurysm as a possible diagnosis when confronted with a large intra-articular mass in the hip after a relatively short follow-up period, particularly in the context of a prior vascular injury at the time of the index procedure.
Acetabular Labral Tear with a Missed Posterior Wall Fracture in an Adolescent Athlete
Authors: Eberlin Christopher T. , Kucharik Michael P. , Martin Scott D.
Published: September 2022

Case:

We present an adolescent contact-sport athlete presenting with hip pain after a traumatic in-play event. After delayed clinical improvement, a magnetic resonance arthrogram (MRA) revealed a posterior acetabular labral tear and the patient was referred for arthroscopic repair. However, subsequent critical interpretation of the MRA demonstrated a missed concomitant posterior acetabular wall fracture, which was later confirmed with computed tomography.

Conclusion:

Despite the low incidence of acetabular fractures in adolescents, this case report highlights the importance of maintaining clinical suspicion in young athletes after a traumatic injury, recognizing the association with labral tears, and acknowledging the limitations of certain imaging modalities.
Optimal management of power sharing based on hybrid fuzzy logic-genetic algorithm of water desalination system integrated with renewable energy
Authors: Zgalmi Abir , rhouma Amine Ben , cherif habib , Belhadj Jamel
Published: September 2022

Coupling renewable energy sources with reverse osmosis desalination systems offers a suitable solution to freshwater scarcity problem, especially in regions suffering from hydraulic and electrical crisis. In this context, design, feasibility and performance evaluation of a standalone brackish water reverse osmosis desalination unit powered with hybrid PV/Wind sources in isolated community have been investigated. In order to reduce the cost of investment and maintenance, the proposed system was based on hydraulic storage in a water tower instead of electrochemical storage. This study aims to optimize the power sharing of the generated power between the motor-pumps while respecting constraints and maximize the produced freshwater quantity. For this purpose, a genetic algorithm optimization of the fuzzy-logic membership functions is proposed. First, a simple fuzzy logic system was used to improve the power sharing between the hydro mechanical processes. Then, an offline optimization of the developed fuzzy-logic using genetic algorithm was applied. Finally, to validate the developed optimal energy management strategy performance, single fuzzy-logic and hybrid fuzzy logic-genetic algorithm energy management system results are compared for a real power profiles. The optimized fuzzy-logic energy management strategy demonstrated its high performance in improving the system energy efficiency with the reduction of the consumed energy (gain of 7.1% in October (Autonm)), and enhance the permeate water production (gain of 2.96% during a week) compared with the energy management based only fuzzy-logic strategy.
Trends of antihypertensive, antidiabetic, and non-steroidal anti-inflammatory drugs use among the Health Workers Cohort Study, Mexico 2004 to 2018.
Authors: Ortega-Montiel Janinne , Montoya Alejandra , Soria-Saucedo René , Gallegos-Carrillo Katia , Ramírez-Palacios Paula , Salmerón Jorge , Salazar-Martinez Eduardo
Published: September 2022

Purpose
Hypertension and Type 2 Diabetes (T2D) are the most prevalent non-communicable diseases in Mexico and worldwide. The principal chronic management therapy is daily oral medication according to international practice management guidelines. We aim to describe the trends of the utilization of antihypertensive, antidiabetic, and non-steroidal anti-inflammatories drugs (NSAID) among Mexican adult population from 2004-2018 through three waves.
Methods
We conducted a longitudinal analysis using data from the Health Workers Cohort Study (HWCS), males and females, aged > 18 years. The prevalence of chronic diseases and utilization for every kind of antihypertensive, antidiabetic, and NSAIDs (measured by self-reported utilization) were calculated in each of the three study waves, and trends were analyzed using Fisher’s exact test.
Results
Hypertension prevalence increased from 19.8 to 30.3%, same as Diabetes prevalence from 7.0 to 12.8% through fourteen years of follow-up. The proportion of patients using beta-blockers and angiotensin receptor blocker II increased, same as the self-reported dual therapy. Regarding T2D, the prevalence of metformin utilization rose to 83.9%. The utilization of common NSAIDs, mainly for muscular pain, remained around 13 to 16%.
Conclusions
Our findings showed markedly changing utilization drugs prevalence for hypertension and T2D between 2004 and 2018, and consistent utilization of NSAIDs (acetaminophen mainly) in the adult Mexican population.
Non-Small-Cell Lung Cancer Promotion by Air Pollutants
Authors: Swanton Charles , Hill William , Lim Emilia , Lee Claudia , Weeden Clare , Augustine Marcellus , Chen Kezhong , Kuan Feng-Che , Marongiu Fabio , Evans Edward , Moore David , Rodrigues Felipe , Maldegem Febe van , Boumelha Jesse , Veeriah Selvaraju , Rowan Andrew , Naceur-Lombardelli Cristina , Karasaki Takahiro , Sivakumar Monica , Caswell Deborah , Nagano Ai , Ryu Min Hyung , Huff Ryan , Li Shijia , Magness Alastair , Suarez-Bonnet Alejandro , Priestnall Simon , Lüchtenborg Margreet , Lavelle Katrina , Pethick Joanna , Hardy Steven , McRonald Fiona , Lin Meng-Hung , Troccoli Clara , Ghosh Moumita , Miller York , Merrick Daniel , Keith Robert , Bakir Maise Al , Bailey Chris , Saal Lao , Chen Yilun , George Anthony , Abbosh Chris , Kanu Nnennaya , Lee Se-Hoon , McGranahan Nicholas , Berg Chistine , Grönroos Eva , Downward Julian , Jacks Tyler , Carlsten Christopher , Malanchi Ilaria , Hackshaw Allan , Litchfield Kevin , Jamal-Hanjani Mariam , DeGregori James
Published: September 2022

Environmental carcinogenic exposures are major contributors to global disease burden yet how they promote cancer is unclear. Over 70 years ago, the concept of tumour promoting agents driving latent clones to expand was first proposed. In support of this model, recent evidence suggests that human tissue contains a patchwork of mutant clones, some of which harbour oncogenic mutations, and many environmental carcinogens lack a clear mutational signature. We hypothesised that the environmental carcinogen, <2.5μm particulate matter (PM2.5), might promote lung cancer promotion through non-mutagenic mechanisms by acting on pre-existing mutant clones within normal tissues in patients with lung cancer who have never smoked, a disease with a high frequency of EGFR activating mutations. We analysed PM2.5 levels and cancer incidence reported by UK Biobank, Public Health England, Taiwan Chang Gung Memorial Hospital (CGMH) and Korean Samsung Medical Centre (SMC) from a total of 463,679 individuals between 2006-2018. We report associations between PM2.5 levels and the incidence of several cancers, including EGFR mutant lung cancer. We find that pollution on a background of EGFR mutant lung epithelium promotes a progenitor-like cell state and demonstrate that PM accelerates lung cancer progression in EGFR and Kras mutant mouse lung cancer models. Through parallel exposure studies in mouse and human participants, we find evidence that inflammatory mediators, such as interleukin-1ꞵ, may act upon EGFR mutant clones to drive expansion of progenitor cells. Ultradeep mutational profiling of histologically normal lung tissue from 247 individuals across 3 clinical cohorts revealed oncogenic EGFR and KRAS driver mutations in 18% and 33% of normal tissue samples, respectively. These results support a tumour-promoting role for PM acting on latent mutant clones in normal lung tissue and add to evidence providing an urgent mandate to address air pollution in urban areas.
Maternal anxiety forecasts shorter prolongation of pregnancies complicated by early-onset preeclampsia
Authors: Esch Joris J.A. van , Bolte Antoinette C. , Spaanderman Marc E.A. , Vandenbussche Frank P.H.A. , de Weerth Carolina , Beijers Roseriet
Published: September 2022

Purpose: In early-onset preeclampsia, each additional day of pregnancy prolongation reduces offspring infant mortality about 9%. We evaluated if maternal stress at admission to hospital for early-onset preeclampsia predicted admission-to-delivery intervals in days.
Methods: This prospective, longitudinal cohort-study involved 15 singleton pregnancies with a diagnosis of preeclampsia before 34 weeks gestation with intended expectant management. Upon hospital admission, maternal psychological stress was assessed with questionnaires and physiological stress with hair cortisol. Hair samples were analysed in three hair segments representing the preconception period, and the first and second trimester of pregnancy.
Results: Mean pregnancy prolongation was 15 days. Higher maternal anxiety at hospital admission significantly correlated with shorter admission-to-delivery intervals (r=-.64, p=.01). Chronically increased hair cortisol concentrations (i.e., from preconception through the second trimester) of pregnancy tended to be related to shorter admission-to-delivery intervals (p=.06).
Conclusion: Higher reported anxiety is, and chronically high hair cortisol tended to be, related with fewer days of prolongation from admission to delivery in women with early-onset preeclampsia. These findings suggest that maternal stress might be a potential determinant of disease progression. Future research into early innovative stress-reducing interventions for early-onset preeclampsia may shed more light on the etiology and treatment of this disease.