bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of a lipid metabolism disorder model in ApoEb mutant zebrafish
Authors: Hu Yang-Xi , You Hong-Min , Zhu Rong-Fang , Liang Yu-Lai , Li Fang-Fang , Qin Yong-Wen , Zhao Xian-Xian , Liang Chun , Jing Qing
Published: May 2022

Background and aims: ApoEb
is a zebrafish homologous to mammalian ApoE, whose deficiency would lead to lipid metabolism disorders (LMDs) like atherosclerosis. We attempted to knock out the zebrafish ApoEb, then establish a zebrafish model with LMD.
Methods
ApoEb was knocked out using CRISPR/Cas9 system, and the accumulation of lipids were confirmed by Oil Red O staining, confocal imaging, and lipid measurements. The lipid-lowering effects of simvastatin (SIM), ezetimibe (EZE) and Xuezhikang (XZK), an extract derived from red yeast rice, were evaluated through in vivo imaging in zebrafish larvae.
Results
In ApoEb mutant, significant vascular lipid deposition occurred, and lipid measurement performed in whole-body homogenate of larvae and adult plasma showed significantly increased lipid levels. SIM, EZE and XZK apparently relieved the hyperlipidemia in ApoEb mutants, and XZK had a significant inhibitory effect on the recruitment of neutrophils and macrophages.
Conclusions
In this study, a LMD model has been established in ApoEb mutant zebrafish. We suggest that this versatile model could be applied in studying hypercholesterolemia and related vascular pathology in the context of early atherosclerosis as well as the physiological function of ApoE.
SABRes: A tool for in silico detection of drug resistance conferring mutations in SARS-CoV-2 genomes
Authors: Fong Winkie , Rockett Rebecca , Agius Jessica , Johnson-Mackinnon Jessica , Chandra Shona , Sim Eby , Lam Connie , Arnott Alicia , Gall Mailie , Draper Jenny , Maddocks Susan , Chen Sharon , Kok Jen , Dwyer Dominic , O'Sullivan Matthew , Sintchenko Vitali
Published: May 2022

The emergence of resistance to antiviral drugs increasingly used to treat SARS-CoV-2 infections has been recognised as a significant threat to COVID-19 control. In addition, some SARS-CoV-2 variants of concern appear to be intrinsically resistant to several classes of these antiviral agents. Therefore, there is a critical need for rapid recognition of clinically relevant polymorphisms in SARS-CoV-2 genomes associated with significant reduction of drug activity in virus neutralisation experiments. Here we present SABRes, a bioinformatic tool, which leverages on expanding public datasets of SARS-CoV-2 genomes and allows detection of drug resistance mutations in consensus genomes as well as in viral subpopulations. We have applied SABRes to detect resistance-conferring mutations in over 25,000 genomes generated over the course of the SARS-CoV-2 pandemic in Australia.
LncRNA STAT4-AS1 inhibited TH17 cells differentiation by targeting RORγt protein
Authors: he hanlin , qiu xiangjie , qi mingming , Bajinka Ousman , qin ling , TAN YURONG
Published: May 2022

Objective: From our previous study, we obtained long non-coding RNA (lncRNA) STAT4-AS1, which is related to asthma through high-throughput screening. However, we could not determine the specific mechanism involved and in response to this, We further designed this study. Results: First, we found that lncRNA STAT4-AS1 was downregulated in T cells from patients with asthma when compared to healthy controls. Next, we confirmed that lncRNA STAT4-AS1 was significantly negatively correlated with T helper 17 (TH17) differentiation in vitro experiments. The decreases of STAT4-AS1 promoted TH17 differentiation, while the increases of STAT4-AS1 inhibited TH17 differentiation. Subsequently, through RNA pulldown, RNA-binding protein immunoprecipitation (RIP) and dual luciferase reporter assay, we found that STAT4-AS1 could inhibit the binding of retinoid-related orphan receptor-γt (RORγt) protein with IL-17A promoter after binding with RORγt protein. Fluorescence in situ hybridization (FISH) and nuclear-cytoplasmic separation assay showed that STAT4-AS1 is bonded to RORγt in the cytoplasm, preventing RORγt from entering the nucleus. Conclusion: Overall, STAT4-AS1 directly targets RORγt protein, inhibits the mutual binding of RORγt and IL-17 gene promoter, and eventually inhibits TH17 differentiation. To this end, STAT4-AS1 as a potential target may confer applications in the clinical treatment and diagnosis of TH17-related diseases.
Use of second anti-TNF agent in inflammatory bowel disease when first agent failed: A South African retrospective study
Authors: Fredericks Ernst , Titus Abigail , Fortuin Suereta , Gabriel Shiraaz , Setshedi Mashiko
Published: May 2022

Background: Inflammatory bowel disease is a chronic relapsing and remitting inflammation of the bowel. Tumour necrosis factor α - antagonists are safe and effective in the treatment of IBD. Indications and outcomes with consecutive anti-TNF agent, although often used, are not clear. Since data for this treatment choice is scarce, we set out to evaluate the use of consecutive anti-TNF agents in patients with IBD.Method: A national registry established by The South African Gastroenterology Society was used for retrospective data extraction in patients with consecutive anti-TNF agent use. Demographic, clinical details, treatment outcomes and adverse events were documented. Results: Eight-six (7.5%) of 1150 patients received consecutive TNFα-antagonists. There were 41 (48%) patients with Crohn’s disease and 45 (52%) with ulcerative colitis. Gender distribution was equal with 45 (52%) male and 41 (48%) female patients. Patients failed the first anti-TNF over 30 months, but remission rates improved with second agent. Immunomodulator therapy had no effect of anti-TNF discontinuation rates. Adalimumab treatment had higher rate of dose escalation/switching as well as adverse events compared to infliximab. Most patients remained in clinical remission except a few with CD who required surgery.Conclusion: Using a second anti-TNF agent when the first agent failed is often necessary in IBD. Although cost-effective, this strategy lacks clarity. Patient selection is crucial and therapeutic drug monitoring should be central in that decision. Adalimumab is associated with higher rates of dose escalation and a worse side-effect profile. Patients with UC switched earlier compared to CD.
Standardized use of a combined topical preparation in the complex treatment of thrombophlebitis of the superficial veins of the lower extremities
Authors: Katorkin S. E. , Melnikov M. A. , Kushnarchuk M. Y. , Yarovenko G. V. , Myshentsev P. N.
Published: May 2022

Introduction. Treatment of thrombophlebitis should be complex and, along with mandatory compression, include both systemic and local use of drugs.

Aim. To evaluate the efficacy and safety of the standardized use of the combined drug indomethacin/troxerutin in gel in real clinical practice in the treatment of superficial vein thrombophlebitis.

Materials and methods. The study included 71 patients with varicose veins complicated by superficial vein thrombophlebitis. In group I patients (n = 35), topical drugs were not used. In group II patients (n = 36), combined drug indomethacin/troxerutin in gel was used daily. The drug was applied to the skin of the lower extremities three times a day, 4–5 cm of gel. Its total daily amount did not exceed 20 cm of gel. The observation period was 10 days. A dynamic scoring of clinical symptoms was performed using a linear analog scale and thermometry of the skin of the lower extremities.

Results. On day 10, patients of the main group showed a statistically significant decrease in thermographic parameters in the area of thrombophlebitis: Tmin – 33.23 ± 0.12 °C, Tmax – 39.86 ± 0.24 °C, Tmean – 40.01 ± 0.16 °C (p ≤ 0.05). When assessing the symptoms of thrombophlebitis using a linear analog scale after 10 days of treatment, there was a general decrease in the number of points in the control group to 16.4 ± 0.12 and in the main group to 12.3 ± 0.16 points (p ≤ 0.05).

Conclusion. Combined drug indomethacin/troxerutin in gel is an effective and safe combined drug for the treatment of patients with thrombophlebitis of the superficial veins of the lower extremities.
“Medical neo-education”: How can a surgeon prove his qualification?
Authors: Zubkov D. S.
Published: May 2022

,
Non surgical therapy for chronic anal fissure
Authors: Abritsova M. V. , Torchua N. R. , Bogdanova E. M. , Markina M. A.
Published: May 2022

Introduction. Sphincterotomy is a pathogenetically justified method of surgical treatment of chronic anal fissures with spasm of the sphincter, but the risk of anal incontinence can reach 44%. Therefore, other methods are being sought to eliminate spasm of the sphincter, and the greatest interest is the medical relaxation of the internal sphincter.

Aim. To determine the efficacy and limitations of the use combined preparation in the form of a gel of 0.3% nifedipine and 2.0% lidocaine for the treatment of chronic anal fissure.

Materials and methods. All patients included in the study were recommended to apply gel 2 times a day with an interval of 12 hours on the skin of the anus and inside the anal canal. In total, the results of treatment of 40 patients were analyzed.

Results. Before the start of treatment, the average pain during defecation was 5 (4.5; 7), on the third day of treatment – 4 (4; 5), and on the 10th day – 2 (2; 3). By day 10, 80% (32) of patients refused to take painkillers. On day 21, complete epithelialization was observed in 31 (77.5%) patients. The average healing time of anal fissures was 17 ± 3 days. In patients with complete epithelization of anal fissures, according to the results of EMG on the 21st day of therapy, spontaneous wave activity was absent. In 9 patients, despite the reduction of pain, sphincter spasm persisted after therapy and cracks in the anal canal did not heal.

Discussion. When analyzing the reasons that led to the ineffectiveness of the use of gel, it was revealed that in all cases, according to ultrasound studies, there were fibrous changes in the internal anal sphincter.

Conclusion. Summarizing the above-mentioned, we can state that the use of a fixed-dose combination of 0.3% nifedipine and 2.0% lidocaine is effective for the treatment of chronic anal fissure with sphincter spasm.
La enseñanza recíproca entre pares no-expertos: comparación entre enseñanza individual y enseñanza de pareja
Authors: Roselli Néstor Daniel , Cardoni Juliana
Published: May 2022

El objetivo de esta investigación es comparar la enseñanza recíproca individual entre alumnos (pares no-expertos) con la enseñanza no-experta realizada en pareja respecto a diversos aspectos relativos a la cualidad y calidad de las mismas. La primera enseñanza tiene como destinatario al compañero de díada (en reciprocidad); la segunda es realizada conjuntamente por los integrantes de una díada y tiene como destinatario a otra díada (y recíprocamente). En general, los estudios sobre la tutoría entre pares no-expertos referida a la enseñanza de conocimientos omiten la cuestión particular de la enseñanza compartida con un alter. La hipótesis central es que este tipo de docencia no-experta compartida genera diferencias de cualidad y calidad respecto a la docencia no-experta individual. Participaron 14 estudiantes universitarios de una misma clase agrupados aleatoriamente en díadas, los que, previo aprendizaje de la episteme a enseñar provista por un texto-fuente, realizaban primero una tutoría enseñante individual dirigida al compañero/a (y viceversa), y luego una tutoría compartida con éste dirigida a los integrantes de otra díada (y viceversa). Las sesiones fueron audio-grabadas. Esta comparación individual-colectivo se refiere tanto a aspectos cualitativos de la enseñanza, como a aspectos relativos a su calidad. En cuanto a los primeros, los datos muestran significativas diferencias respecto al estilo de enseñanza y a la dependencia respecto del texto-fuente, y diferencias moderadas relativas a la calidad. Se concluye con una propuesta de diferenciación de distintas modalidades de la relación individual-colectivo.
Direitos Humanos: concepções por estudantes de psicologia em uma universidade pública brasileira
Authors: Mello Leonardo Cavalcante de Araújo , Pedroza Regina Lucia Sucupria
Published: May 2022

O artigo versa sobre compreensões que estudantes de psicologia produzem acerca da relação dessa ciência e profissão com os Direitos Humanos. Para tanto, o artigo traça um panorama geral acerca da história dos Direitos Humanos, dando centralidade à possibilidade de diferentes concepções desses direitos, indo de uma visão hegemônica, à perspectiva de que esses direitos são frutos de processos históricos, sociais e culturais. Para atingir o objetivo, foi realizada aplicação de questionário com perguntas abertas à estudantes de psicologia. As informações construídas foram analisadas por meio da Análise de Conteúdo Temática, de maneira a se evidenciar duas categorias (núcleos de sentido): Concepções acerca dos Direitos Humanos, e Psicologia e Direitos Humanos: uma relação necessária? Concluímos que as concepções de Direitos Humanos dos estudantes de psicologia participantes são majoritariamente liberais e naturalistas, e eles têm a percepção de que a formação fornece poucos elementos teóricos e práticos para que o psicólogo atue alinhado aos ideais dos Direitos Humanos.
O massacre no presídio de Altamira: interseções entre racismo ambiental e necropolítica na região norte
Authors: Faria Erick Melo Fernandes , Freitas Nikaelly Lopes de
Published: May 2022

Considerando-se o histórico anterior do Pará e das condições específicas que corroboraram com o massacre no Presídio de Altamira, assim como o contexto social, econômico e político de infrações de direitos humanos cometidas na América Latina, percebe-se o descaso em relação a uma população que é sistematicamente segregada e destituída de suas condições mínimas de vivência. Nesse contexto, o presente artigo tem como objetivo demonstrar de que forma o racismo ambiental tem influenciado a incrementação do encarceramento em massa na América Latina, indicando aspectos em comum entre massacres ocorridos nos presídios brasileiros que acabam por constituir mais uma faceta da manifestação da necropolítica, destacada pela inércia Estatal no oferecimento de direitos básicos à população. Apresente pesquisa qualitativa, utilizou-se de revisão bibliográfica a partir de livros, artigos científicos, relatórios e jornais, para o embasamento teórico e documental que representam o liame entre os fatos noticiados e teorias sobre formas de dominação, como o racismo ambiental e a necropolítica, importantes marcos para se entender como o Estado se torna responsável, mesmo que, indiretamente, por centenas de mortes da população negra, ou pela deterioração da vida de indígenas e outros vulneráveis — o que categoriza um processo acobertado por preconceitos a serem desconstruídos. Portanto, tornam-se urgentes medidas a serem tomadas para que a grave situação seja revertida com base, neste caso, nas Regras de Mandela fornecidas pela ONU para mínimas condições de tratamento de presos, que, atualmente, são amplamente desrespeitadas.
APLIKASI PADA TIME TEMPERATURE INDICATOR (TTI) EKSTRAK KUNYIT (Curcuma domestica .Val) UNTUK MONITORING KUALITAS SUSU KEDELAI
Authors:   Politeknik Negeri Jakarta, Ningtyas Rina , Setyani Rani ,   Politeknik Negeri Jakarta, Muryeti Muryeti ,   Politeknik Negeri Jakarta
Published: May 2022

Susu kedelai adalah produk yang rentan mengalami kontaminasi dan kesalahan penyimpanan (handling), sehingga diperlukan kemasan cerdas Time Temperature Indicator (TTI) untuk mendeteksi kualitas susu kedelai. Pembuatan TTI dengan menggunakan membran indikator (kertas saring whatman) divariasikan derbandingan jumlah ekstak kunyit dan NaOH 1:3, 1:5, dan 1:7. Pembuatan TTI menggunakan komposisi, dan pengeringan membran asetat dalam waktu 40, 50, dan 60 menit. Kualitas susu kedelai menjadi tidak segar pada suhu ruang jam ke–6 (nilai pH 6.34) dan pada jam ke 48 (nilai pH 6.32) pada suhu kulkas. Skor organoleptik menunjukan ciri-ciri basi pada jam ke–6 (suhu ruang) dan jam ke–48 (suhu kulkas). Uji mikroba menunjukan tidak lagi layak konsumsi pada jam ke – 6 penyimpanan suhu ruang (6.89 log CFU/ml) dan jam ke 48 penyimpanan kulkas (5.68 log CFU/ml). Hasil menunjukan bahwa aplikasi TTI menggunakan ekstrak kunyit dapat memonitoring kualitas susu kedelai pada suhu ruang namun tidak pada suhu kulkas. Dengan variasi yang tepat untuk suhu ruang adalah 1:7, dengan pengeringan membran asetat 60 menit.
Kurpiowszczyzna – dominujące zmiany w krajobrazie pod wpływem czynników społeczno-ekonomicznych w okresie transformacji ustrojowejS
Authors: Starzyk Agnieszka
Published: May 2022

Kurpiowszczyzna to jeden z ciekawszych regionów etnograficznych, z ośrodkiem oryginalnej, świetnie zachowanej i pieczołowicie kultywowanej kultury ludowej Kurpiów. Obraz wsi kurpiowskiej jest wynikiem wielowiekowych działań człowieka. Na przestrzeni stuleci następowały przekształcenia krajobrazu, oparte na przystosowywaniu środowiska przyrodniczego do uprawy ziemi i stopniowym zakładaniu siedzib ludzkich, które dały obraz współczesny. Tradycyjna kultura ludowa kurpiowskiej grupy etnograficznej oraz wysoka wartość środowiska przyrodniczego były inspiracją do podjęcia badań z zakresu transformacji otwartego krajobrazu osadniczego regionu kurpiowskiego. Celem pracy było zbadanie procesów decydujących o przekształceniach krajobrazu naturalnego i kulturowego Kurpiowszczyzny. Zakres terytorialny pracy obejmuje obszar Kurpiowszczyzny położony między Omulwią i Szkwą, który w XV w. znalazł się w powiecie ostrołęckim i w nim pozostał. Zakres czasowy badania obejmuje okres od pierwszych wzmianek o zasiedlaniu obszaru do czasu przystąpienia Polski do Unii Europejskiej. Przyjęte zostały następujące metody badawcze: analizy bibliograficznej i piśmiennictwa dotyczącego tematu pracy, analizy historycznej obejmującej rozwój osadnictwa na badanym terenie, analizy kartograficznej porównawczej w zakresie osadnictwa i przekształcania krajobrazu, analizy statystycznej w zakresie infrastruktury społecznej i technicznej. W pracy posługiwano się także inwentaryzacją krajobrazową i urbanistyczno-ruralistyczną. Struktura cyklu, zawarta w siedmiu artykułach, obejmuje zagadnienia związane z kształtowaniem i rozwojem osadnictwa na obszarze Kurpiowszczyzny: 1) Kurpiowszczyzna w badaniach naukowych, 2) Kurpiowszczyzna w kulturze ludowej, 3) Kurpiowszczyzna – zarys kształtowania funkcji osadniczo-rolniczych i krajobrazu, 4) Kurpiowszczyzna – charakterystyka krajobrazu osadniczego, 5) Kurpiowszczyzna – dominujące zmiany w krajobrazie pod wpływem czynników społeczno-ekonomicznych w okresie 45-lecia powojennego, 6) Kurpiowszczyzna – dominujące zmiany w krajobrazie pod wpływem czynników społeczno-ekonomicznych w okresie transformacji ustrojowej. Cykl zamyka artykuł dotyczący współczesności: 7) Kurpiowszczyzna – 18 lat od wstąpienia Polski do Unii Europejskiej (publikacja w 2022). Słowa kluczowe: Kurpie, architektura, krajobraz osadniczy, krajobraz przyrodniczy, krajobraz kulturowy
Adaptability Study of Yield and Yield Related Trait Performance of Improved Food Barley (Hordeum Vulgare L.) Varieties in North Shewa Zone Oromia, Ethiopia
Authors: Negash Geleta , Girma Solomon
Published: May 2022

Barley is one of the founders, old world agriculture and the first domesticated cereal crop. It is a staple food, adapted to and produced over a wider range of environment . This trial was conducted on sixteen improved food barley varieties with one local check at Fitche Agricultural Research Center for two consecutive years. The objective was to identify adaptable, stable and high yielding varieties. The seed was sown in Randomized Complete Block Design with three replications. Nine agronomic traits data were evaluated. Analysis of variance detected significant difference among varieties for most observed traits both separated and combined analysis. Observation attained significant differences over years and locations for almost all traits. The combine ANOVA and the AMMI analysis for grain yield across environments revealed significantly affected by environments, hold 68.4% of the total variation. Genotype and genotype by environmental interaction were significant and accounted 12.1 % and 17.8 % respectively. Principal component 1 and 2 accounted 9.6% and 4.3 % of the GEI respectively with a total of 13.9 % variation. The interaction effect of variety by year and variety by location imposed significant effect on most traits. Among evaluated varieties; HB1307 and HB1966 had significantly higher mean value of grain yield. Moreover, the yield advantage of 32.9% and 38.8% were estimated for HB1307 and HB1966 respectively over the local check. Therefore, these varieties were suggested for further demonstration and popularization in the areas with similar agro-ecology.
Analysis of Family Values of the Two Generations of Godfathers in the Film The Godfather
Authors: Yanfeng Du , Yang Yang , Manfu Duan
Published: May 2022

The Mafia is a secret organization originated in Italy. Despite its notoriety in the world, there still are a great number of people who are interested in it. A large number of cultural works have been produced because of people’s infatuation and curiosity about Mafia culture. Take the film of The Godfather as an example, which is produced in 1972. This film has not only influenced millions of people, but introduced Italy Sicilian’s mafia culture to the whole world.Indeed, people’s stereotype for mafia is blood, cruelty and brutality, however, the mafia also has another rational and warm look. This paper aims to make a more in-depth analysis of the classic film The Godfather from a new perspective of "family values" by grasping the historical background, cultural environment of the film and the life and destiny of Italian immigrants at the end of the WW II. In the process of analysis, this paper focuses on grasping the communication and contact between the main characters in the film, and analyzes the family warmth and love revealed in it.
Academic Quality Dimensions and its influence on Students’ Satisfaction
Authors: Macedo Maria Erilucia Cruz
Published: May 2022

Today in many industries service quality is widely used in different sectors. Every sector whether services sector or manufacturing can apply and implement five dimensions of service quality. The purpose of this study is to reveal the impact of service quality on student’s satisfaction in education sectors. The findings of the study will show impact of different service quality dimensions on students’ satisfaction in a private university. This study is useful to see the significance of service quality to satisfy students. SERVQUAL model of service quality provided by (Parasuraman, et al., 1988) is implemented. It includes five dimensions tangible, reliability, responsiveness, assurance and empathy. Findings of this study showed that four of service quality dimensions (tangible, responsiveness, assurance and empathy) have positive association with student satisfaction, except reliability have negative association with student satisfaction.
A Study on Customer Satisfaction on OTT Platforms during Covid19 Pandemic Period
Authors: Hemalatha Dr. T. M. , Kumar. A Mr. Kishore , Kumar. S Mr. Sathish
Published: May 2022

Abstract: An Over-The-Top(OTT) platform is a virtual media carrier added immediately to audiences over the Internet. The agencies that traditionally function a controller or distributor of such content, along with cable, radio, and satellite TV for pc TV channels, are bypassed with the aid of using OTT. It's additionally been prolonged to no-service mobile phones, which invoice all communications as data, stopping monopolistic competition. OTT additionally refers to a brand new technology tv networks like traditional satellite tv for pc or cable TV carriers, provide stay streams of linear area of expertise channels over the Internet instead of a closed, non-public community of proprietary system like set-pinnacle boxes. The transition from conventional media to OTT platform, particularly because of COVID-19, has brought about a war among to draw streaming carriers and keep subscribers all through the lockdown duration. Hence this study is mainly focused on satisfaction of Consumer using OTT. Keywords: Customer engagement Covid -19-OTT platforms
Automatic Door Lock System Using Face Recognition
Authors: Nagpure Asmita , Sonule Mayuri , Chauhan Surja , Bhowate Shreya , Meshram Kunal , Gorewar Prof. H. V.
Published: May 2022

Abstract: In this paper we've proposed face recognition door cinch system using jeer pi for security purpose. Perpetration of the system is for covering whether any unknown person is entering in to the door. In order to get accurate and clear picture of an meddler we've proposed Haar Cascade system for face discovery. As soon as the person enters near the door, pi camera captures the image and face discovery process is done also if it matches with database images also the door is uncorked else a communication with the picture of a person will be transferred to the registered mobile through LAN network. The main aphorism of this design is to application of detector with the combination of bedded outfit for the door opening systems. The main purpose of this system is to give better security by using face recognition fashion
Health Issues in Animals in Zoo as Compared to Wildlife Sanctuary
Authors: Sharma Komal
Published: May 2022

Abstract: Zoos aren't a moral manner of displaying animals to society when you consider that they have got negative outcomes at the animals’ intellectual health, motive human dependency from a younger age, as properly as forcing them to stay in negative enclosure setups. “Zoochosis” refers back to the emotional and intellectual demanding situations that have an effect on the animals which are held in captivity, which can be usually visible as uncommon and repetitive behaviors. Pacing, overgrooming, and repetitive motion of the jaw are all examples of mental problems that animals come to be struggling with at the same time as in captivity. We took Leopard of Nahargarh in Cage Leopard Maya of Jhalani Dungari kajal as comparison look at of intellectual problems of animals. We determined that the Leopard in Nahargarh confirmed one of a kind behaviour in comparison to the Jahalani dungari leopard. After studying there behaviour and consulting the respective Veterinary we came to know that Maya tha Naragarh zoo leopard showed drastic negative behaviour in comparison so the Kajal Japani Dungari national park Leopard. The hunting ability were finished in zoo leopard. Keywords: behaviors, Captivity, infection, intellectual, Zoochoisis.
An Energy Efficient Clustering Protocol Using CM-YSGA Optimization Approach in WSN
Authors: Shaheen Aaina , Ghai Poonam
Published: May 2022

Abstract: While dealing with the wireless sensor networks (WSNs), one of the greatest factors that must be taken into consideration is energy consumption of nodes. One of the most effective common way of preserving energy in sensor nodes is clustering technique in which CH selection is of great importance. In this manuscript, an improved energy efficient clustering protocol is proposed in which chaotic mapping algorithm is clubbed along with the advanced variant of Yellow Saddle Goatfish Algorithm (YSGA). The main objective of the proposed model is to reduce the energy consumption of nodes which ultimately prolongs the lifespan of wireless network. Initially, cluster are formed in the network by selecting the nodes randomly. After this, four important parameters which included, residual energy, distance to sink, average distance to CH neighbor node and delay are taken into consideration and on the basis of these factors’ fitness value is calculated by the chaotic-YSGA technique. The node whose fitness value came out to be highest of all other nodes, is selected as the CH in that particular cluster. In addition, the Huffman data compression technique is used in the proposed system to reduce energy consumption in nodes. Finally, the performance of the proposed Chaotic-YSGA model is analyzed and compared with conventional energy efficient models in MATLAB software in terms of alive node, dead nodes, throughput, residual energy, FND, HND and LND. Keywords: WSN, Energy Efficiency, CH selection, Optimization Algorithms.
Smart Watch for Elderly Person
Authors: Gupta Sanidhya , Rai Shitanshu , Yadav Rupesh , Singh Ruchika
Published: May 2022

Abstract: In India ,the current senior citizen population of 130 million is expected to grow more than double to 300 million to constitute 20 percent of the population[1].With a rapidly growing 60-plus population, India is faced with herculean task of providing senior-friendly urban infrastructure. Around 64% of adult fall prey to depression and loneliness in urban area. There is also been a significant increase in crime rate against senior citizens being left at home alone.Also,the senior population is most exposed and vulnerable to Covid-19 infections and fall ill often. This paper aims to develop a smartwatch equipped with health monitoring and fall detection techniques for elderly population using a microcontroller’s main component in used in this is an Arduino which is a microcontroller equipped/connected with sensors which can detect the health parameters such as pulse rate, body temperature etc. It also been equipped with fall detection technique which can detect the fall of user wearing the smartwatch and can send SOS to the caretakers concerned with that user.All the previous smartwatches are developed keeping in mind the general population, however this device is solely dedicated to the senior population and act as a health monitoring device. Keyword: CoVID-19, Smartwatch, Microcontroller, Arduino, SOS
Diversity and Potential of Flowering Plants in Timau Mutis Nature Reserve, Tasinifu Village
Authors: Tnunay Ite Morina Yostianti , Prima R. Makin Florian Mayesti , Welsiliana
Published: May 2022

Background: The mountain ecosystem in Mutis Timau Nature Reserve, Oelmuke Village, has a high diversity of flowering plants but has not been recorded. Inventaritation of the flowering plant provides reference information for area conservation. This study aims to inventory the types and uses of flowering plants by the community and other potential benefits in the Mutis Timau Nature Reserve, Oelmuke Hamlet, East Nusa Tenggara. Method: This research was conducted in August 2019 in Oelmuke Village, East Nusa Tenggara. The plant collection was conducted using an experimental method along the Oelmuke Village area. The information on the use of flowering plants by the community using the interview method and information about other potential uses using the literature review method. Result: The flowering plants inventoried from Oelmuke Village is 31 species from 15 families that have been used as food, animal feed, building materials, medicinal materials, ornamental plants, hedge plants, firewood, and cigarette raw materials, and textile materials. Other potential uses are as an accumulator of Pb waste and dye for woven fabrics. Conclusions: The 31 species of plants that have been inventoried have been used by the community as food, animal feed, building materials, medicinal materials, ornamental plants, hedges, firewood, cigarette raw materials, and textile materials and other potential uses are accumulator Pb waste and dyes for woven fabrics
Utilization of Natural Dyes for Futus Woven Fabrics as an Alternative to Dye for Plant Tissue Preparations
Authors: Naisumu Yolanda Getrudis , Emilia Juliyanti Bria  , Welli Herlince Kasse
Published: May 2022

Background: Natural plant dyes can replace synthetic dyes to reduce the negative effects caused. This study aims to determine the types of color-producing plants, the process of using natural dyes as dyes for plant tissue preparations and the percentage of quality and feasibility of plant tissue preparations. Methods: experiments were carried out in the application of natural plant dyes on plant tissue preparations. Data analysis was carried out to calculate the percentage of quality and feasibility of the preparations. Results: there were eight plant species from four families namely Fabaceae, Zingiberaceae, Maliaceae, and Lamiaceae. The process of processing plant parts into natural dyes is by soaking, boiling, pounding, grated and applied to preparations of corn and spinach plants. The use of natural dyes on corn and spinach preparations with a percentage of preparation quality ranging from 33.33% - 75.00% and said to be poor to good, while the percentage of feasibility of preparations ranged from 67.08% - 87.50% and was said to be feasible to very suitable for use in the observation of plant cells and tissues. Conclusions: Natural dyes from futus fabrics can replace synthetic dyes in dyeing plant tissue preparations.
VARIABILITY OF THE CONTENT OF BIDENS CERNUA HERB BIOLOGICALLY ACTIVE SUBSTANCES IN THE STORAGE PROCESS
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Lapava N.V.
Published: May 2022

The aim is to study the variability of the content of Bidens cernua herb biologically active substances in the storage process. The content of biologically active substances (polysaccharides and flavonoids) in Bidens cernua herb during storage for two years was monitored every 3 months for two series: series A simulated the storage of medicinal plant raw materials prior to their use in industrial production, series B completely repeated the most frequently used packaging for herbal medicines. Additionally, the content of the dominant flavonoids quercitrin and luteolin-O-7-glucoside, as well as the product of its hydrolysis, luteolin, was assessed annually by liquid chromatography. It has been established that a decrease in the polysaccharides content by no more than 5% in series A was observed within 9 months, in series B - within 12 months. After 24 months of storage, the polysaccharides content in Bidens cernua herb was higher in series B. A decrease in the content of the sum of flavonoids by no more than 5% was observed within 6 months for both series. After 24 months, the content of the sum of flavonoids, as well as quercitrin and luteolin-O-7-glucoside, was higher in series A. Thus, the choice of the optimal packaging for storing Bidens cernua herb will be determined by the requirement for the quality of medicinal plant raw materials in terms of the content of biologically active substances, which, in its turn, will determine the expected pharmacological activity of this type of medicinal plant material.
PROCESSING ULTRASONIC PROBES AT DIFFERENT RISKS OF INFECTION
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Dikareva E.A. , Pimanov S.I. ,   Vitebsk State Order of Peoples' Friendship Medical University
Published: May 2022

Everywhere in clinics of different countries, there is an insufficiently adequate processing of sensors and other elements of ultrasound (US) equipment, and this often happens due to lack of awareness of US diagnostics specialists. The purpose of the given work was to analyze the literature data on the principles of processing US probes. To prevent the transmission of microorganisms, the choice of the probe processing option is regulated by the general rules for disinfection of reusable medical devices in accordance with regulatory documents. US probes that come into contact with intact skin are non-critical devices. Such equipment should be cleaned and processed with the help of low to moderate disinfection. US probes that come into contact with damaged skin, blood, body fluids and mucous membranes are considered to be semi-critical and require high-level disinfection and the use of special disposable coatings. Critical devices include US probes that are used for invasive procedures. Sterilization, if possible, or high-level disinfection are used to clean these probes. Furthermore, the use of special disposable coatings is mandatory when examining patients from the risk group. The best option for choosing a disinfection mode, from the point of view of maintaining the operability of the probe, is the recommendation of the US equipment manufacturer.
Percepção de parturientes sobre experiência de parto em uma maternidade pública baiana
Authors: Gazar Thalita Nascimento , Cordeiro Gleice de Oliveira , Souza Jackeline Maria de
Published: May 2022

A assistência ao parto tem passado por muitas transformações. Sintetizadas em protocolos, essas transformações buscam humanizá-la. No entanto, é importante escutar parturientes para compreender se essas mudanças se concretizam na prática da assistência. Nesta pesquisa descritiva, avaliou-se a experiência de parto de parturientes em uma maternidade pública de Feira de Santana, na Bahia. Por meio de um questionário, foram consultadas cinquenta mulheres, entre novembro de 2019 e janeiro de 2020. Os dados foram analisados no SPSS, versão 22.0, mediante análises descritivas e inferenciais. Foram considerados os aspectos éticos de pesquisa com seres humanos, conforme o parecer nº 3.656.149. As participantes tinham entre 18 e 41 anos. Nesse grupo, 92% delas eram negras e 74% multíparas. Foi identificado que 94% das participantes se sentiram respeitadas, 88% com a privacidade resguardada e 84% se sentiram seguras. Constatou-se que 88% adotaram posições horizontais para o parto, 56% receberam ocitocina e 24% amamentaram no pós-parto imediato. As médias de satisfação foram altas em relação: à equipe de saúde (M = 9,74; DP = 0,69); ao espaço físico (M = 9,3; DP = 0,99); e à experiência de parto (M = 8,62; DP = 1,93). Características individuais e condutas adotadas pelos profissionais no parto foram fatores influentes para essa avaliação. Em comparação com outros atendimentos realizados em Feira de Santana e na Bahia, constatou-se uma experiência de satisfação acima da média. Experiências como essa sugerem um caminho em que a assistência abandone os procedimentos proscritos e incentive o protagonismo feminino por meio de comunicação efetiva e estimulação à escolha da posição de parto e ao aleitamento precoce.
Techno-economic evaluation of integrated levulinic acid, formic acid, and furfural plant from oil palm empty fruit bunch with pre-treatment variations
Authors: GOZAN Misri A , RAHMAN Denia Apriliani , HARAHAP Andre Fahriz Perdana
Published: May 2022

AbstractLevulinic acid, a platform biochemical, might be utilized as a biodiesel additive in biodiesel production. Global demand for levulinic acids was 3,820 tons in 2020, while the roadmap target of biodiesel in Indonesia will reach 20% of diesel consumption in 2016-2025. These figures become the considerations for establishing the levulinic acid plant in Indonesia. The study's focus analyzed the economic viability of integrated levulinic acid production plant design based on Oil Palm Empty Fruit Bunches (OPEFB) in Indonesia. OPEFB was selected as raw material due to the enormous solid waste generated by oil palm plantations. In the plant design, software SuperPro Designer 9.0's used as a process tool simulator. The economic analysis showed the Net Present Value (NPV) as the US $ 548,850,764, an Internal Rate of Return (IRR) of 24.75%, and a payback period (PBP) estimated within six years with a Minimum Attractive Rate Return (MARR) of 6.1%. The optimal production capacities of levulinic acid, furfural, and formic acid are 12,425; 15,105 and 6,074 tonnes/year.[Keywords: cellulose, delignification, levulinic acid, OPEFB, simulation] AbstrakAsam levulinat, sebuah platform biokimia, dapat digunakan sebagai aditif biodiesel dalam produksi biodiesel. Permintaan global asam levulinat mencapai 3.820 ton pada 2020, sedangkan roadmap target biodiesel di Indonesia mencapai 20% dari konsumsi solar pada 2016-2025. Angka-angka ini menjadi pertimbangan untuk mendirikan pabrik asam levulinat di Indonesia. Fokus penelitian menganalisis kelayakan ekonomi rancangan pabrik produksi asam levulinat terpadu berbasis Tandan Kosong Kelapa Sawit (TKKS) di Indonesia. TKKS dipilih sebagai bahan baku karena limbah padat yang dihasilkan perkebunan kelapa sawit sangat besar. Dalam perancangan pabrik, software SuperPro Designer 9.0 digunakan sebagai alat simulator proses. Analisis ekonomi menunjukkan Net Present Value (NPV) sebesar US$ 548.850.764, Internal Rate of Return (IRR) 24,75%, dan payback period (PBP) diperkirakan dalam enam tahun dengan Minimum Attractive Rate Return (MARR) 6,1%. Kapasitas produksi optimal asam levulinat, furfural dan asam format masing-masing adalah 12.425; 15.105 dan 6.074 ton/tahun.[Kata kunci: selulosa, delignifikasi, asam levulinat, TKKS, simulasi]
Bulking of physically nonlinear plates under the action of dynamic shearing loads
Authors: Ivanov Sergey P.
Published: May 2022

The study of the stability of plates under shear under the action of dynamic loads is one of the important problems of structural mechanics. The plates are widely used in construction, mechanical engineering, shipbuilding and aircraft building. The paper presents a method for calculating plates for shear buckling, taking into account the physical nonlinearity of the material. A plate is considered under the action of a shearing dynamic load along the edges. The calculation is based on the Kirchhoff - Love hypotheses and the hypothesis of a non-linear elastic body. The plate material is assumed to be physically nonlinear. The deformation diagram is approximated as a cubic polynomial. The deflection of the plate points is determined in the form of Vlasov - Kantorovich expansions. Basic non-linear differential equations are derived using the energy method. Lagrange’s equations are used to obtain the resolving equations for plate buckling. On the basis of the developed technique, a calculation was made for the stability of a physically nonlinear square plate under the action of a shear dynamic load. The edges of the plate are hinged. The finite system of nonlinear differential equations is integrated numerically by the Runge - Kutta method. Based on the results of calculations, plots of the dependence of the relative value of the deflection of the central point of the plate on the dynamic coefficient Kd (with and without taking into account the physical nonlinearity of the material) are plotted. The influence of the degree of physical nonlinearity of the material, the parameter of the rate of change of the shear load on the criteria for the dynamic stability of a square plate is studied.
The nexus between financial transparency and the financial obstacle level of the enterprises in the Western Balkan region
Authors: Iballi Nazmi , Sulejmani Liza Alili , Rexha Donat
Published: May 2022

Access to finance plays a crucial role in the growth of small and medium enterprises (SMEs), thus affecting the development of the emerging countries. SMEs, which record their transactions under international accounting standards and use external auditors, finance their growth and working capital through formal external sources (Nizaeva & Coskun, 2018). In addition, the decision-making process of crediting depends particularly on the SMEs’ financial reporting, thus it requires complete transparency of their financial reports. Taking into consideration the important role that financial transparency plays in the access to finance as well as its impact on the SMEs’ growth, the main aim of this paper is to analyze the impact of the financial transparency on the financing obstacles of the SMEs operating in the Western Balkan countries, through the usage of the survey data collected from the 6th Business Environment and Enterprise Survey (BEEPS VI), enabled by European Bank for Research and Development (EBRD) and the World Bank, related to the survey time period 2018–2020. In this regard, probit and ordinary least squares (OLS) techniques have been employed, where the results reveal that financial transparency has a significant negative effect on the financing obstacles of the enterprises of the Western Balkan region. Besides financial transparency, firm-specific factors such as age and size have been included in the model and the findings show that crucial determinants of the financing obstacles these companies have in this region
Idiopathic Acquired True Leukonychia Totalis and Partialis- A case report with Review of literature
Authors: Pandey Prajwal , Pathak Raksha
Published: May 2022

Leukonychia totalis and partialis are characterized by complete or
partial whitening of nail plate. They can be inherited or acquired.
Rarely, no cause or associations are found. Here, we report a case of a
17-year-old male with idiopathic acquired true leukonychia totalis and
partialis.
High-power, short-duration ablation of the atrioventricular node
Authors: Alsaiqli Mahmoud , Ahmed Rafsan , Freytes Leonell , Rehaw Ola , Chandrakumar Harshith , Budzikowski Adam , Jallad Ahmed
Published: May 2022

Introduction Atrioventricular node (AVN) radiofrequency
ablation is a highly effective treatment of atrial tachycardias
resistant to other management modalities. There are limited studies that
compare different radiofrequency ablation catheters. Our study aimed to
compare the effectiveness of several types of ablation catheters in AVN
ablation. Methods We identified patients who underwent AVN
ablation for different indications at our institution. Data related to
patients and procedures were collected through retrospective chart
review. The radiofrequency catheters used were: plain non irrigated,
externally irrigated (EI), and contact force sensing with 10-20 gm of
force in two different settings: low power long duration (LPLD) (30W,
45°C, and 60 sec) and high-power short duration (HPSD) (50W, 43°C, and
12 sec). We compared the different catheters in terms of success rate
using logistic regression and lesion time using linear regression.
Results We identified 66 patients who underwent AVN ablation,
out of which 31 were female (47%). The patients were elderly, with a
mean age of 73.27 years. The indications were resistant atrial
fibrillation in 74%, atrial flutter in 18%, and other atrial
tachycardias in 8% of patients. Types of catheters used were plain non
irrigated in 48%, EI in 2%, LPLD in 16%, and HPSD in 34% of
patients. All ablation procedures were successful with no immediate
post-procedure complications. Regarding lesion time, HPSD was
significantly shorter compared to plain catheters by 403.42s[-631.67,
-175.17]. Conclusions Radiofrequency ablation of AVN is a
highly effective treatment modality for atrial tachyarrhythmias that
failed other management methods. While plain catheter, LPLD, and HPSD
were equally safe and effective, HPSD catheter had significantly shorter
lesion time and thus procedure time.