bluuebunny/crossref_metadata_2025 huggingface dataset:
Minimum dietary diversity and associated factors among children aged 6-23 months in Ghana: a cross-sectional study
Authors: Ativor Pearl Saraphina , Salu Samuel
Published: August 2023

Background: The golden period in the first 1000 days of life is between the ages of 6 and 23 months. This period is referred to as a critical window because it promotes the optimal growth and development of the child. However, the nutritional status of children in this critical period is strongly influenced by their feeding patterns, which in turn has an impact on their survival. Inappropriate supplementary feeding techniques put children under the age of two at danger of malnutrition, illness, and death. This study therefore, assesses the minimum dietary diversity and its associated factors among children between the age 6-23 months in the Hohoe Municipality, in the Volta Region of Ghana.
Methods: A health facility-based cross-sectional study was conducted from April to July 2021. A multi-stage sampling technique was used to sample 422 study participants. Data were collected with a paper-based questionnaire, coded and entered into Epi-Data version 3.1. Data extraction was carried out in Excel Sheet for cleaning and then later exported into STATA V.16.0 for analysis. Logistic regression was fitted to identify significant factors associated with high MDD at 95% CI and a p-value < 0.05.
Results:Out of the 422 participants, majority of them 343 (81.0%) had good dietary practices. The prevalence of MDD among the children was 17.1%. On the other hand, the educational level of mothers [cOR=3.12 (95% CI: 1.57-6.19), p=0.001], their ethnicity [cOR=4.69 (95% CI: 1.55-14.19), p=0.006], their occupation [cOR=2.18 (95% CI: 1.15-4.11), p=0.017] and their dietary practices [cOR= 0.72 (95% CI: 0.13-3.92), p=0.008] were found to be significantly associated with children’s MDD. After controlling for other co-variates, only educational level [aOR=3.16 (95% CI: 0.75-13.29), p=0.001] and ethnicity [aOR=24.72 (1.43-15.64), p=0.011] were statistically associated with children’s high MDD.
Conclusion: The study concludes that while MDD was low among the children, breastfeeding was common but gaps existed in providing essential food groups, with significant influences from maternal education and ethnicity, highlighting the need for targeted interventions to enhance dietary practices for children aged 6-23 months.
Anti-inflammation study of cellulose-chitosan biocomposite-based Tetrapleura tetraptera (Taub) dried fruits aqueous extract
Authors: Fokou Jean Baptiste Hzounda , Nsegbe Annick Christianne , Yen Beglau Thi Hai , Fetzer Marcus N. A. , Mbogbe Elise Nadia , Nkouankam Maeva Jenna Chameni , Mponge Pamela Ngadie , Baleng Marie Tryphene Magaly Ngo Yomkil , Songue Sylvie Pascale , Kuissi Chris Rosaire Ninpa , Koube Juliette , Enone Bertin Sone , Ntoumba Agnes Antoinette , Meva Francois Eya’ane , Janiak Christoph
Published: August 2023

Nanotechnology is making exceptional progress in the medical field. The development of new systems for the delivery of plant ingredients brings benefits such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocomposites from Tetrapleura tetraptera despite its wide range of ethnopharmacological uses including management of the inflammatory diseases. This study aimed to prepare chitosan and cellulose-based nanocomposite with anti-inflammatory potential. The biocomposite showed an encapsulation efficiency of 69.4%. Their formation was confirmed by a peak at 290 nm in UV-Vis. Infrared spectrophotometry proves the formation of a mixed polysaccharide and polyphenols system. No signs of toxicity and no deaths were found, therefore the lethal dose 50 (LD50) is higher than 2000 mg/kg. The biocomposite has an anti-inflammatory activity in vitro with a maximum inhibition of 99.5% and an anti-inflammatory activity in vivo with a maximum inhibition of 98.7% for a dose of 200 mg/kg. The synthesized biocomposite from the aqueous extract of the fruits of Tetrapleura tetraptera showed an anti-inflammatory property with satisfactory safety.
Order-preserving Property of One-parameter Expo nential Distribution MLE under Type-I Censoring
Authors: Liu Xiaofeng , Ren Jianguo , Bingliang Shen , Ping Luo
Published: August 2023

Many researchers have studied various properties of maximum likelihood estimators as well as estimators for truncated samples.However,the order preserving properties of maximum likelihood estimation for censored samples have not been studied in the literature. This is precisely the subject of this paper. In this paper, we derive general necessary conditions under which the MLE has the general necessary conditions. In particular, the paper obtains conditions under which the one-parameter exponential, location, and scale families satisfy the order preserving property.
Human-AI Collaborative Decision-making: A Cognitive Ergonomics Approach
Authors: Neyigapula Bheema Shanker
Published: August 2023

This research paper explores the dynamic interplay between human cognition and artificial intelligence (AI) in the context of decision-making, employing a cognitive ergonomics framework. As AI technologies continue to evolve and inte- grate into various aspects of human life, the collaboration between humans and AI becomes increasingly significant. This study investigates the cognitive load experienced by individuals during collaborative decision-making processes with AI systems, aiming to optimize interface design for enhanced cognitive perfor- mance. Leveraging principles of cognitive ergonomics, the research examines how varying degrees of AI involvement impact decision-making efficiency, user trust, and transparency. By employing a mixed-methods approach involving cognitive workload assessments and user experience analyses, the study sheds light on the intricacies of human-AI collaboration. The findings not only contribute to the theoretical understanding of cognitive ergonomics in the context of AI but also offer practical insights for the design and implementation of effective human-AI decision support systems.
When two Z-scores meet - Analysis of exercise capacity of children and adolescents with Kawasaki disease by a new Z-score model of coronary artery and a new Z-score evaluating peak oxygen consumption
Authors: Tuan Sheng-Hui , Chung Jin-Hui , Chen Guan-Bo , Sun Shu-Fen , Liou I-Hsiu , Li Chien-Hui , Tsai Yi-Ju
Published: August 2023

Background
Coronary artery (CA) Z-score system is widely used to define CA aneurysm (CAA). Children and adolescents after acute stage of Kawasaki disease (KD-CA) have a higher risk of developing CAAs if their CA Z-score ≥ 2.5. Z-score system of peak oxygen consumption (Peak VO2 Z-score) allows comparisons across ages and sex, regardless of body size and puberty. We aimed to compare the exercise capacity (EC) indicated by peak VO2 Z-score during cardiopulmonary exercise testing (CPET) directly between KD-CA with different CA Z-score.
Methods
KD-CA after acute stage who received CPET in the last 5 years were retrospectively recruited. CA Z-score was based on Lambda-Mu-Sigma method. Max-Z was the maximum CA Z-score of different CAs. KD children with Max-Z < 2.5 and ≥ 2.5 were defined as KD-1 and KD-2 groups, respectively. Peak VO2 Z-score was calculated using the equation established based on Hong Kong Chinese children and adolescent database.
Results
102 KD-CA were recruited (mean age: 11.71 ± 2.57 years). The mean percent of measured peak VO2 to predicted value (peak PD%) was 90.11 ± 13.33. All basic characteristics and baseline pulmonary function indices were comparable between KD-1 (n = 87) and KD-2 (n = 15). KD-1 had significantly higher peak VO2 Z-score (p = .025), peak PD% (p = .008), peak metabolic equivalent (p = .027), and peak rate pressure product (p = .036) than KD-2.
Conclusions
KD-CA had slightly reduced EC than healthy peers. KD-CA with Max-Z ≥ 2.5 had significantly lower peak EC than those < 2.5. Max-Z is potentially useful follow-up indicator after acute stage of KD.
Magnetic Nanoparticle Supported Choline Chloride-Glucose (Deep Eutectic Solvent) for the One-Pot Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones
Authors: Atharifar Hengameh , Keivanloo Ali , Maleki Behrooz , Baghayeri Mehdi , Alinezhad Heshmatollah
Published: August 2023

One efficient method for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives catalyzed magnetic deep eutectic solvent is reported. The structure of the nano-catalyst was characterized by FE-SEM, FT-IR, EDX, and TGA. Then, the excellent activity of the catalyst was displayed for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives. This heterogeneous catalyst can be easily recovered via a magnetic field and reused for subsequent reactions. Easy workup, high yields in a short time and non-toxic catalyst are the main merits of this method.
Regional monthly rainfall prediction based on CEEMDAN-SSA-BiLSTM coupled modeling
Authors: Zhang Xianqi , Ren He , Liu Jiawen
Published: August 2023

Accurate rainfall prediction plays a vital role in optimizing water resource management, reducing impacts on water resources and related water conservation and utilization.. This study combines the advantages of CEEMDAN model's ability to handle nonlinear and nonstationary data, SSA model to decompose and reconstruct the data to get the subsequence with spatio-temporal information, BiLSTM model to effectively learn the dependency relationship between the current data and the data of the previous moment, and to use the relationship to predict the rainfall in the future moments to construct the regional monthly rainfall prediction model of CEEMDAN-SSA-BiLSTM and applied it to predict monthly rainfall in Kaifeng City. The findings indicate that the proposed model is effective for accurately predicting monthly rainfall in the city of Kaifeng. Compared with the EMD-SSA-BiLSTM, CEEMDAN-BiLSTM, and BiLSTM models, the CEEMDAN-SSA-BiLSTM model achieves higher accuracy with an average absolute error (MAE) of 3.75, an average absolute percentage error (MAPE) of 5.44%, and a coefficient of determination (R2) of 0.99. Furthermore, the decomposition of monthly rainfall time series signals helps in identifying and revealing cycles and trends in the series, thereby effectively improving the prediction accuracy of monthly rainfall.
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis.
Authors: Pérez-Acuña Dayana , Shin Soo Jean , Rhee Ka Hyun , Kim Sang Jeong , Lee Seung-Jae
Published: August 2023

The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neurodegeneration, and this extracellular α-synuclein can affect synaptic transmission. However, whether and how the spreading of α-synuclein aggregates modulates synaptic function before neuronal loss remains unknown. In the present study, we investigated the effect of intrastriatal injection of α-synuclein preformed fibrils (PFFs) on synaptic activity in the somatosensory cortex using a combination of whole-cell patch-clamp electrophysiology, histology, and Golgi-Cox staining. Intrastriatal PFF injection was followed by formation of phosphorylated α-synuclein inclusions in layer 5 of the somatosensory cortex, leading to a decrease in synapse density, dendritic spines, and spontaneous excitatory post-synaptic currents, without apparent neuronal loss. Additionally, three-dimensional reconstruction of microglia using confocal imaging showed an increase in the engulfment of synapses. Collectively, our data indicate that propagation of α-synuclein through neural networks causes abnormalities in synaptic structure and dynamics prior to neuronal loss.
Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment
Authors: Loureiro Liliana Rodrigues , Hoffmann Lydia , Neuber Christin , Rupp Luise , Arndt Claudia , Kegler Alexandra , Kubeil Manja , Hagemeyer Christoph E. , Stephan Holger , Schmitz Marc , Feldmann Anja , Bachmann Michael
Published: August 2023

Background
Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infiltration and immunosuppressive tumor microenvironments (TME) are major hurdles. Fibroblast activation protein (FAP) is highly expressed on cancer-associated fibroblasts (CAFs) and various tumor cells, playing an important role in tumor growth and immunosuppression. Aiming to modulate the TME with increased clinical safety and effectiveness, we developed novel small and size-extended immunotheranostic UniCAR target modules (TMs) targeting FAP.
Methods
The specific binding and functionality of the αFAP-scFv TM and the size extended αFAP-IgG4 TM were assessed using 2D and 3D in vitro models as well as in vivo. Their specific tumor accumulation and diagnostic potential was evaluated using PET studies after functionalization with a chelator and suitable radionuclide.
Results
The αFAP-scFv and -IgG4 TMs effectively and specifically redirected UniCAR T-cells using 2D, 3D, and in vivo models. Moreover, a remarkably high and specific accumulation of radiolabeled FAP-targeting TMs at the tumor site of xenograft mouse models was observed.
Conclusions
These findings demonstrate that the novel αFAP TMs are promising immunotheranostic tools to foster cancer imaging and treatment, paving the way for a more convenient, individualized, and safer treatment of cancer patients.
Health risk assessment from habitants of Araró, Michoacán, México, exposed to arsenic by dust, using Monte Carlo probabilistic method.
Authors: Mendoza José , Aguilar Alejandra , Rodríguez Laura , Guerra Roberto , Meza Diana , Meza Mercedes , Martínez Marco Antonio
Published: August 2023

Arsenic (As) is a worldwide distributed metalloid; and its environmental exposure by various media has been associated with some diseases such as: lung, skin, bladder and pancreas cancers, diabetes, cardiovascular disorders and atherosclerosis. Environmental presence of As may be due to natural origin, human activities or geothermal processes. Michoacán is located in the volcanic transverse system which is a highly active geothermal site in center México. The aim of this research was to assess the health risk for As exposure by dust of Araró´s population using Monte Carlo simulation. 40 dust samples were randomly collected in Araró village, located in northeast Michoacán, and these were analyzed using portable X-ray fluoroscopy. The arsenic levels obtained for the dust samples were in the range of 5.94–42.53 mg/kg. Health risk was assessed using USEPA formulas and Monte Carlo Simulation for oral, dermal and inhalation pathways. Anthropometrical data were obtained from the Health and Nutrition National Survey 2018.Mean average daily dose (ADD) for all age groups (preschooler, schooler, adolescent and adult) were below of safety criteria. 4 and 6% of preschooler and schooler dermal ADD’s were above of safety criteria. In the same way, hazard quotient (HQ) and hazard index (HI) mean values were below of safety criteria. Nevertheless, it was found that dermal carcinogenic risk (CR) value for adults tends to represents a potential cancer risk. Despite of relatively low As concentration reported it is remarkable that more As exposition routs must be explore in order to determine problem severity.
Commuters' mode and parking decisions
Authors: Wagner Jake , Moore Danna , Jessup Eric , Vakoch Daniel
Published: August 2023

We analyze how both fee and non-fee commute attributes affect commuters’ mode and parking decisions. Results show commuters are sensitive to the price, travel time, egress time, and search time in selecting their primary commute mode, but are not sensitive to other travel costs including the costs of fuel and maintenance. Using these results we conduct policy simulations to analyze how changes in transit prices, travel times, and parking availability affect commuters' mode and parking decisions. We find raising parking permit prices and decreasing bus travel times to be effective in reducing the number of single occupancy vehicle commuters; the closure of central parking locations, however, is found to be ineffective in discouraging commuters from driving to campus as drivers are more likely to switch parking locations than they are commute modes.
miR-483-3p targets FGFR2 to inhibit cardiomyocyte pyroptosis NLRP3/Caspase-1/GSDMD signaling axis and reduce myocardial fibrosis
Authors: Lv Xiangwei , Chen Liqin , He Zifeng , Zhang Mingyu , Chen Rongyan , Xu Tongtong
Published: August 2023

Purpose
In this study, the role of miR-483-3p in reducing myocardial fibrosis (MF) is investigated and the underlying molecular mechanism is further explored.
Methods
Firstly, six SD rats were randomly divided into sham surgery (Sham) group and model (ISO) group, and high-throughput miRNAs sequencing technology was used to sequence MF model rats. Forty male SD rats were randomly divided into Sham group, ISO group, blank transfection (AAV-NC) group, and overexpression (AAV-miR-483-3p) group, with 10 rats in each group. The MF model was established by tail vein injection of isoprenaline. RT-PCR, Western Blot and immunohistochemical staining were used to detect the expression of miR-483-3p, FGFR2 and cell pyroptosis. Bioinformatics software TargetScan was used to predict targets online and verify with diluciferase reporters; Detection of myocardial fibrosis using HE staining, Masson staining and Western Blot.
Results
Compared with the ISO group, the degree of MF decreased in the AAV-miR-483-3p group, and the expression of Collagen-1, FGFR2, NLRP3, Caspase-1, GSDMD and IL-1β in cardiomyocytes was significantly reduced. Diluciferase experiments confirmed that FGFR2 is the validated target gene of miR-483-3p.
Conclusion
miR-483-3p targets FGFR2 to inhibit cell pyroptosis and reduce the degree of MF, possibly via the NLRP3/Caspase-1/GSDMD signaling axis.
Truncation of the Calmodulin Binding Domain in Rice Glutamate Decarboxylase 4 (OsGAD4) Leads to Accumulation of γ-Aminobutyric Acid and Confers Abiotic Stress Tolerance in Rice Seedlings
Authors: Akter Nadia , Kulsum Ummey , Yasuda Nobuto , Akama Kazuhito
Published: August 2023

Background Gamma-aminobutyric acid (GABA) is a non-protein amino acid known as a major inhibitory neurotransmitter. It is mainly synthesized from glutamate via the enzyme glutamate decarboxylase (GAD). GAD is present in all organisms, but only plant GAD has been shown to bind Ca2+/calmodulin (CaM). This binding suppresses the auto-inhibition of Ca2+/CaM binding domain (CaMBD) when the active site of GAD is unfolded, resulting in stimulated GAD activity. OsGAD4 is one of the five GAD genes in the rice genome. Conserved motifs in the C-terminal amino acid sequence suggest the potential ability of this GAD isoform to bind to Ca2+/CaM. Our aim was to produce GABA-fortified rice plants by genome editing of the OsGAD4 gene and comprehensive study of the truncated mutants.Results An in vitro Ca2+/CaM assay showed that the C-terminal region of putative GAD4 has the ability to bind to Ca2+/CaM. CRISPR/Cas9-mediated genome editing was performed to trim the coding region of CaMBD from the OsGAD4 gene. Rice calli infected with Agrobacterium carrying an all-in-one vector harboring guide RNAs and CRISPR/Cas9 was used to regenerate rice plants. We produced 27 independent transgenic lines (T0) through genome editing. DNA sequence analysis revealed the truncation of CaMBD (216 bp). Genome-edited line (#14 − 1) produced 12.9 mg GABA/100 g grain, which is almost 9-fold higher than the wild-type. Abiotic stresses such as salinity, flooding, and drought significantly enhanced GABA accumulation in #14 − 1 plants at various time points compared with wild-type controls in the same stress conditions. Moreover, upregulated mRNA expression in vegetative tissues seem to be correlated with the stress responsiveness of OsGAD4 when exposed to the above-mentioned stresses. The stress tolerance of OsGAD4 genome-edited plants was demonstrated by the higher survival rate, suggesting induced tolerance against abiotic stresses in rice.Conclusions Trimming of the intact Ca2+/CaMBD of the C-terminal region of OsGAD4 induced extreme GABA accumulation in plant tissues. This elevated level of GABA was found to be linked to abiotic stress tolerance in rice plants at the vegetative stage.
Prevalence of Plasmodium sp. infection on endemic primates in the Buton Utara Wildlife Sanctuary, Southeast Sulawesi, Indonesia
Authors: Lempang Meyby Eka Putri , Permana Dendi Hadi , Asih Puji Budi Setia , Wangsamuda Suradi , Dewayanti Farahana Kresno , Rozi Ismail Ekoprayitno , Setiadi Wuryantari , Syahrani Lepa , Muslimin Lucia , Malaka Ratmawati , Syafruddin DIn
Published: August 2023

Background
The recent emergence of zoonotic malaria in many parts of Indonesia alerts the need to establish mitigation efforts to prevent and contain the cases. The archipelago of Indonesia is home to many species of non-human primates (NHPs), and massive deforestation has substantially reduced the NHPs' habitat and intensified the interaction between NHPs and humans. The present study aims to determine the malaria prevalence among the NHPs in the Buton Utara Wildlife Sanctuary (BUWS) and the risk of zoonotic malaria among the human inhabitant adjacent to the site.
Methods
Epidemiologic surveys were conducted to determine the prevalence of malaria on endemic primates inhabiting BUWS, Indonesia, between 2020 and 2021 through the capture and release of NHPs. Traps were installed in several localities surrounding the sanctuary that border the human settlement. The captured primate was anesthetized, and blood samples were aseptically drawn using phlebotomy to make a blood smear and dried blood spot (DBS) on filter paper.
Results
Analysis of the DNA extracted from the DBS revealed that ten of the 26 captured primates were infected with Plasmodium inui, 2 with P. cynomolgi, and 1 with P. simiovale. Molecular analysis on the primate species caught indicated that all were macaques and originated from one species, Macaca brunnescens as evidenced by the barcoding DNA markers using mitochondrial DNA (mtDNA) Cytochrome Oxidase Subunit I (COI) and internal transcribed spacer 2 (ITS2) of the nuclear ribosomal DNA.
Conclusions
Overall, the findings indicate a high prevalence of malaria among NHPs in the wildlife sanctuary forest and deserve further surveillance to prevent spill-over to the human inhabitant surrounding the sanctuary.
Assessment and analysis of tree damage caused by forest road construction in a scotch pine stand: A case study from Alabarda/Bolu-Türkiye
Authors: Türk Yılmaz , Bodur Mücahit
Published: August 2023

The aim of this study is to determine the forest road construction area and environmental impact area, and to determine the tree injuries caused by forest road construction, the filling area covering the stand, and the distances of the trees directly affected by the tree injuries from the road axis. In this direction, 700 meters of the forest road numbered 194 within the boundaries of Alabarda Forest Management Sub-Directorate (Bolu/Turkey) was selected as the study area. The forest road environmental impact area was found by determining the rolling boundary of the backfill material with the differential global positioning system (DGPS) device. In addition, the position of the trees in this area in relation to the road and their damage conditions were determined and the wound sizes were measured. As a result of the study, the road construction impact area was 46479 m², the average spread distance of the backfill material was 50.34 m, the average distance of the damaged trees from the road was 28.25 m, and the average distance of the trees that were not damaged was 35.52 m. In addition, a total of 1477 trees were identified in the construction impact area and 427 of these trees were damaged. According to the results of the statistical analyses, a statistically significant positive correlation was determined between bark wound area and diameter. In addition, a statistically significant negative correlation was determined between the distance of the trees from the road axis and the wound area and the height of the backfill.
Enhancing Embedded Systems Development with TS-
Authors: Yu Xingzi , Tang Wei , Xiong Tianlei , Chen Wengang , He Jie , Yang Bin , Qi Zhengwei
Published: August 2023

The lack of flexibility and safety in C language development has been criti- cized for a long time, causing detriments to the development cycle and software quality in the embedded systems domain. TypeScript, as an optionally-typed dynamic language, offers the flexibility and safety that developers desire. With the advancement of Ahead-of-Time (AOT) compilation technologies for TypeScript and JavaScript, it has become feasible to write embedded applications using TypeScript. Despite the availability of writing AOT compiled programs with TypeScript, implementing a compiler toolchain for this purpose requires substantial effort.
To simplify the design of languages and compilers, this paper presents a new compiler toolchain design methodology called TS−, which advocates the generation of target intermediate language code (such as C) from TypeScript rather than the construction of higher-level compiler tools and type systems on top of the intermediate language. TS− not only simplifies the design of the system but also provides developers with a quasi-native TypeScript development experience. This paper also presents Ts2Wasm, a prototype that implements TS− and allows compiling a subset of language TypeScript to WebAssembly (WASM). The tests from the repository TypeScript show that Ts2Wasm provides 3.8x as many features compared to the intermediate language (AssemblyScript). Regarding performance, Ts2Wasm offers a significant speed-up of 1.4x to 19x. Meanwhile, it imposes over 65% less memory overhead compared to Node.js in most cases.
Tracking the first electron transfer step at the donor side of oxygen-evolving photosystem II by time-resolved infrared spectroscopy
Authors: Dekmak Mohamad Yahia , Mäusle Sarah M. , Brandhorst Janosch , Simon Philipp S. , Dau Holger
Published: August 2023

In oxygen-evolving photosystem II (PSII), the multi-phasic electron transfer from a redox-active tyrosine residue (TyrZ) to a chlorophyll cation radical (P680+) precedes the water-oxidation chemistry of the S-state cycle of the Mn4Ca cluster. Here we investigate these early events, observable within about 10 nanoseconds to 10 microseconds after laser-flash excitation, by time-resolved single-frequency infrared (IR) spectroscopy in the spectral range of 1310–1890 cm− 1 for oxygen-evolving PSII membrane particles from spinach. Comparing the IR difference spectra at 80 ns, 500 ns, and 10 µs allowed for the identification of quinone, P680 and TyrZ contributions. A broad electronic absorption band assignable P680+ was used to trace specifically the P680+ reduction kinetics. The experimental time resolution was taken into account in least-square fits of P680+ transients with a sum of four exponentials, revealing two nanosecond phases (30–46 ns and 690–1110 ns) and two microsecond phases (4.5–8.3 µs and 42 µs), which mostly exhibit a clear S-state dependence, in agreement with results obtained by other methods. Our investigation paves the road for further insight in the early events associated with TyrZ oxidation and their role in the preparing the PSII donor side for the subsequent water oxidation chemistry.
Computation of the masses of the elementary particles
Authors: Mashford John
Published: August 2023

An approach to gauge theory in the context of locally conformally flat space-time is described. It is discussed how there are a number of natural principal bundles associated with any given locally conformally flat space-time X. The simplest of these principal bundles is the bundle PG(X) with structure group G = U(2,2). An 11 dimensional bundle Q with structure group a certain 7 dimensional group K is constructed by a method involving a reduction of structure group for the bundle PG(X). It is shown how the gauge groups U(1), SU(2) and SU(3) can be derived from the geometry of locally conformally flat space-time. Fock spaces of multiparticle states for the fields of the standard model are constructed in the context of bundles with these groups as structure groups. Scattering and other particle interaction processes are defined in terms of linear maps between multiparticle state spaces. A technique for computing analytically and/or computationally the masses of the elementary particles is described. This method involves the computation of a certain quantity called the integral mass spectrum for a given family of particles and then the masses of the particles in the family are determined to be the locations of the peaks of the integral mass spectrum. The method is applied successfully to the cases of the charged leptons and the Z0 boson.
Degeneración olivar hipertrófica postraumática asociada a temblor de Holmes: correlación clínico- imagenológica
Authors: Montero-Cruz Edinson , Mendoza-Ospina Alejandra , Aldana-Bocanegra Jorge Andrés , Montaño-Lozada Juan Manuel , Castillo-Támara Edgard Eliud
Published: August 2023

La degeneración olivar hipertrófica, es una enfermedad secundaria al daño en el circuito neuronal del Triángulo de Guillain Mollaret, generando síntomas tan variados como el temblor de Holmes. El presente artículo describe el caso de un hombre de 52 años, con antecedente de trauma craneoencefálico en 2016, sin secuelas mediatas, quien de manera progresiva presenta temblor, asociándose 5 años después a cefalea requiriendo asistencia a urgencias, allí realizan estudios e instauran terapia farmacológica. Finalmente se concluye, que lesiones postraumáticas en el Triángulo de Guillain Mollaret, pueden generar como secuelas trastornos del movimiento secundarios a degeneración olivar hipertrófica, una entidad poco diagnosticada.
Análise do estado de tensão na característica de sismos induzidos por reservatório para um estudo de caso da UHE de Irapé em Minas Gerais
Authors: Vanderlei da Silveira Iarly , José Pedroso Lineu , De Oliveira de França Júnior Davidson
Published: August 2023

O entendimento do comportamento da avaliação sísmica nas estruturas, em geral, é extremamente importante. Para regiões com sismos com baixas intensidades como o Brasil essa avaliação não é tão difundida, no entanto, existem riscos relacionados aos sismos originados pelo enchimento do reservatório, pouco abordado pelos projetistas, que são desencadeados próximos ao barramento e podem provocar possíveis danos a estrutura. A Usina Hidrelétrica (UHE) de Irapé é a mais alta barragem do país, com 208 metros. Essa barragem foi monitorada pelo Observatório Sismológico da Universidade de Brasília (OBSIS-UnB) no enchimento do reservatório em 2006. Este trabalho objetiva avaliar a influência do enchimento do reservatório da UHE de Irapé e a sua correlação com os dados sísmicos capturados ao longo desse enchimento. Para isso, avaliou-se por meio do método dos elementos finitos via software ANSYS a região de influência do esforço adicional ao longo da crosta local. Os resultados apresentados constataram que os eventos ocorridos durante o enchimento da barragem estão dentro dos limites de variação do estado de tensão, sendo caracterizados como eventos induzidos pelo reservatório sendo predominantemente rasos, se encontrando em uma região de influência em distâncias menores que 4 km da superfície.
Desenvolvimento de Soluções SIG para a Administração Pública Brasileira – Uma Revisão Sistemática
Authors: Teixeira de Oliveira Filho José Antonio , Frata Furlan Peres Fabiana
Published: August 2023

Os Sistemas de Informações Geográficas têm evoluído nos últimos trinta anos, seguindo os avanços de demais tecnologias e se tornando ferramenta fundamental para diversas tarefas, tanto na iniciativa privada quanto no setor público. As características de coletar, armazenar, recuperar e disseminar dados espaciais são de grande utilidade para o desenvolvimento de ações no setor público onde, não raramente, dificuldades como escassez de investimento e de mão de obra se apresentam como desafios a serem superados. Este artigo apresenta uma revisão sistemática da literatura identificando a produção científica entre 2018 e 2022, sobre Sistemas de Informações Geográficas desenvolvidos para o serviço público brasileiro, seus principais atores e campos de aplicação. Para realizar as buscas, foram consideradas as bases de dados indexadas IEEE Digital Library, ISI Web of Science, Science Direct e Scopus. As buscas retornaram 263 artigos, dos quais 79 eram duplicados e 171 não atendiam aos critérios de inclusão estabelecidos. Desse modo restaram 13 artigos para análise. Os resultados possibilitaram avaliar a popularização desses sistemas no âmbito governamental e  revelaram os principais campos de aplicação, os softwares mais utilizados e as outras características a respeito das soluções desenvolvidas no período.
Reconsidering the Role of Fatigue Irregular Testing in Scientific Conclusions About the Fatigue Limit
Authors: Gadolina I. V.
Published: August 2023

Aim. We suggest a method of using the fatigue test in case of irregular loading for studying the key subject matters related to material fatigue, specifically those to do with fatigue limit. It is important to know the fatigue limit characteristic in order to speed up tests; in order to ensure stable and reliable servicing of machines.

Methods. Comparative examinations in cases of block and random loadings enable researchers to make corresponding conclusions without excessively extending the duration of tests and without recurring to supersonic frequency tests that are to a certain degree controversial. An example of applying the proposed method is given. The second stage of fatigue, specifically the crack propagation stage, is also considered. The key idea is similar. Testing under irregular loading allows making conclusions regarding the maximum among small amplitudes that do not cause damage.

Conclusions. The proposed method allows using special testing methods to obtain information that is valuable to engineers and researchers. The tests are also closer to the field conditions of machinery operation.
An intelligent system for constructing metro train driver working schedules
Authors: Markevich A. V. , Sidorenko V. G.
Published: August 2023

Aim. The paper aims to tests and analyse the results of application of an intelligent system for constructing metro train driver working schedules that is intended for automatically improving the efficiency of utilisation of the working time of metro train drivers. In this case, depending on the task at hand and the chosen criterion, efficiency is understood as a reduction of the number of drivers involved in the implementation of the specified standard train schedule, improved uniformity of alternation of driver work and rest periods, as well as reduction of the duration of down time within work shifts.

Methods. The study presented in the paper uses the graph theory, recursive and heuristic algorithms.

Results. The authors have developed recursive algorithms for preparing work schedules for main metro train drivers and substitute drivers that operate during main drivers’ lunch breaks. The developed algorithms are used in the intelligent system for metro train driver work schedule planning. The algorithm for generating main driver work schedule includes driver allocation to a number of work lines preliminarily defined based on the rolling stock operation schedule for the purpose of ensuring traffic according to the planned metro train schedule. The algorithm for generating substitute driver work schedule involves substitute driver work time planning based on the possibility of arranging lunch breaks for main drivers.

Conclusion. The paper presents the results of a trial of the developed intelligent system for train driver work planning for the Moscow Metro using the example of the Zamoskvoretskoye Depot of the Zamoskvoretskaya Line, the Vykhino Depot of the Tagansko-Krasnopresnenskaya Line, as well as the results of the system’s adaptation to the Moscow Central Circle. It also presents a comparative analysis of driver work schedules, i.e., the actual one and one obtained using the developed intelligent system. The application of the developed system may enable as much as a 28% improvement of the efficiency of metro train drivers’ work hour use.
Dependability factors of microprocessor protection software
Authors: Uspensky M. I.
Published: August 2023

Aim. An analysis of the distinctive features of the functional dependability of software that are common to critical real-time applications in respect to microprocessor protections. Dependability indicators are among the primary operational characteristics of relay protection. As such protections migrate to microprocessor technology, it became necessary to characterise their operation and dependability with software dependability along the hardware dependability. The importance of the tasks it solves in the process of operation puts it into the category of programs used in critical real-time applications. That, in turn, toughens the requirements for their dependability evaluation.

Methods. The comparative analysis allowed evaluating the unity of the examined operational dependability factors of the software as part the examined applications, while identifying certain distinctive features that are common to relay protections that use microprocessors.

Results. The paper provides an example of such estimation that shows that, given all the complexity of testing microprocessor protection programs, the contribution of software errors still is 2,5% from the overall contribution.

Conclusion. It is shown that microprocessor protection programs fall into the category of critical real-time application programs, which allows using the experience and characteristics of such software as part of relay protection. Nevertheless, the paper cites certain distinctive features that are common only to microprocessor-based relay protection. Further tasks are specified.
Paper Bags vis-à-vis LDPE Bags: Gleanings from Peer-reviewed E-LCA Publications
Authors: Lidbrand Isabell , Venkatesh Govindarajan , Lestelius Magnus
Published: August 2023

Fossil-plastics or paper? Or for that matter, bio-plastics and paper? This is a well-entrenched question in academic research, industrial, social and policy-making circles. As environmental life-cycle analyses (or more appropriately, sustainability analyses) show time and again, no single product or process or mode of operation is a ‘total villain’. There are goods and bads, and at times, more of the one than the other. This paper, which is based on a course-report written by the first author at Karlstad University (Sweden), restricts itself to a review of publications which have opted to compare paper bags with low density polyethylene (LDPE) plastic bags, on the basis of their environmental impacts. Environmental impact categories include the global warming potential, energy demand, fossil fuel depletion, water usage, acidification, eutrophication, and a range of toxicities – human, terrestrial, freshwater-aquatic and marine-aquatic. The articles were obtained through Google Scholar, read and reviewed to glean the results presented therein. The ‘What’, ‘How’ and ‘Where’, so to say were studied carefully to understand the reasons behind any differences or similarities detected. On the basis of this focused review, even though no new knowledge is being added, the common belief that the paper bag is environmentally superior to the LDPE alternative is further consolidated. However, if one focuses on water usage and would assign a high weightage to that environmental impact, LDPE perhaps may score a few ‘brownie points’ over paper. One must also not forget that plastics (LDPE in this instance) can be recycled without significant deterioration in its functional properties. In a circular economy (the bioeconomy part of which gradually will expand over time), while introducing more and more bio-based products into the technosphere by way of trans-materialization is recommended, plastics will still continue to exist – albeit in much smaller amounts – and it would be perfectly fine if the degree of recycling is augmented significantly. Speaking of a holistic sustainability analysis, the socio-economic aspects of a choice between LDPE and paper bags must also be factored in, and studied. Much-desired change happens when the top-down meets the bottom-up somewhere midway.
concepção genealógica habermasiana dos direitos humanos
Authors: Feldhaus Charles
Published: August 2023

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Habermas e a sociologia da saúde
Authors: Feldhaus Charles
Published: August 2023

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Habermas e a desobediência civil
Authors: Feldhaus Charles
Published: August 2023

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Comprehensive Analysis of Ligand-receptor Interactions in Colon
Adenocarcinoma to Identify of Tumor Microenvironment Oxidative
Stress and Prognosis Model
Authors: Hu Jun , Zhu Wenbo , Wang Wenpeng , Yue Xin , Zhao Peng , Kong Dalu
Published: August 2023

Background:

Single-cell technology enables a deep study on the mechanism of cancers.
This work delineated the function of ligand-receptor interaction in colon adenocarcinoma (COAD),
and developed a LR pairs-based prognostic model.

Methods:

For identifying important LR pairs, Single-cell RNA sequencing data of COAD was included.
Unsupervised consensus clustering constructed molecular subtypes. LASSO established a
prognostic model. Infiltration of 22 immune cells was evaluated by Cibersort. Enrichment score of
oxidative stress related pathways was determined by SsGSEA in each patient.

Results:

Forty-seven LR pairs were closely associated with the prognosis of COAD. Three molecular
subtypes were differentiated according to 47 LR pairs, which displayed differential clinical features
and molecular features. There were significant differences in immune T cell lytic activity
among different subtypes. In clust1 with poor prognosis, significantly enriched oncogenic pathways
were found, especially epithelial-mesenchymal transition (EMT). Additionally, it has been
found that clust3 had significantly higher immune infiltration. A prognostic model containing eight
LR pairs (PDGFB-PDGFRA, FLT4-VEGFC, CSF1R-CSF1, DLL1-NOTCH4, PDGFB-LRP1, DLL1-
NOTCH3, FLT4-PDGFC, and NRP2-PGF) was established, which could effectively divide
samples into low-risk and high-risk groups. Significantly higher oxidative stress was found among
high-risk patients.

Conclusion:

This study integrated expression data and single-cell data for demonstrating the effectiveness
of LR pairs in establishing the prognostic model and constructing molecular subtypes.
Prognostic LR pairs may contribute to tumorigenesis and progression in COAD. The prognostic
model was the potential for predicting prognosis and guiding immunotherapy for COAD patients.
MiR-301b-3p can be used as a Potential Marker for the Diagnosis of Lung
Adenocarcinoma
Authors: Qi Weibo , Niu Niu , Zhao Junjie , Liu Haitao , Yang Fan
Published: August 2023

Background:

The involvement of aberrantly expressed miR-301b-3p has been discovered
in diverse human tumors. Our study was primarily centered around the role of miR-301b-3p in
diagnosing lung adenocarcinoma (LUAD).

Method:

We used the TCGA database to download the TCGA-LUAD dataset and selected miR-
301b-3p as the object of our study by differential expression analysis of miRNAs combined with
previous studies. The LUAD diagnostic model was constructed utilizing machine learning based
on miR-301b-3p expression. The predictive performance of the diagnostic model was found to be
excellent by ROC curves combined with the clinical information of the dataset samples. GSEA,
GO, and KEGG enrichment analyses demonstrated that miR-301b-3p may mediate the cell cycle
by regulating the expression of hormones. Subsequently, combined with tumor immunity and mutation
analysis, it was found that patients in the low-expression group had better immune infiltration,
indicating that their response rate to immunotherapy may be relatively high. Finally, a mouse
xenograft model was constructed to verify how miR-301b-3p affected LUAD progression in mice.

Result:

The results illustrated that overexpressed miR-301b-3p could cause faster tumor growth in
mice. On the contrary, the growth of LUAD could be impeded by the downregulated miR-301b-3p
expression. It was suggested that miR-301b-3p had a crucial part in LUAD progression.

Conclusion:

Overall, the diagnostic performance of the LUAD diagnostic model constructed based
on miR-301b-3p is great, and the model can be used as a potential diagnostic marker for LUAD to
provide new ideas for clinical diagnosis.
Recent Advances in Biomedical Nanotechnology Related to Natural
Products
Authors: Xia Qing , Liang Tingting , Zhou Yue , Liu Jun , Tang Yue , Liu Feila
Published: August 2023

Natural product processing via nanotechnology has opened the door to innovative and
significant applications in medical fields. On one hand, plants-derived bioactive ingredients such
as phenols, pentacyclic triterpenes and flavonoids exhibit significant pharmacological activities,
on another hand, most of them are hydrophobic in nature, posing challenges to their use. To overcome
this issue, nanoencapsulation technology is employed to encapsulate these lipophilic compounds
and enhance their bioavailability. In this regard, various nano-sized vehicles, including
degradable functional polymer organic compounds, mesoporous silicon or carbon materials, offer
superior stability and retention for bioactive ingredients against decomposition and loss during
delivery as well as sustained release. On the other hand, some naturally occurring polymers, lipids
and even microorganisms, which constitute a significant portion of Earth's biomass, show promising
potential for biomedical applications as well. Through nano-processing, these natural products
can be developed into nano-delivery systems with desirable characteristics for encapsulation a
wide range of bioactive components and therapeutic agents, facilitating in vivo drug transport.
Beyond the presentation of the most recent nanoencapsulation and nano-processing advancements
with formulations mainly based on natural products, this review emphasizes the importance of
their physicochemical properties at the nanoscale and their potential in disease therapy.
Thrombin - A Molecular Dynamics Perspective
Authors: Wu Dizhou , Prem Athul , Xiao Jiajie , Salsbury Freddie R.
Published: August 2023

Thrombin is a crucial enzyme involved in blood coagulation, essential for maintaining circulatory
system integrity and preventing excessive bleeding. However, thrombin is also implicated in
pathological conditions such as thrombosis and cancer. Despite the application of various experimental
techniques, including X-ray crystallography, NMR spectroscopy, and HDXMS, none of these
methods can precisely detect thrombin's dynamics and conformational ensembles at high spatial and
temporal resolution. Fortunately, molecular dynamics (MD) simulation, a computational technique
that allows the investigation of molecular functions and dynamics in atomic detail, can be used to explore
thrombin behavior. This review summarizes recent MD simulation studies on thrombin and its
interactions with other biomolecules. Specifically, the 17 studies discussed here provide insights into
thrombin's switch between 'slow' and 'fast' forms, active and inactive forms, the role of Na+ binding,
the effects of light chain mutation, and thrombin's interactions with other biomolecules. The findings
of these studies have significant implications for developing new therapies for thrombosis and cancer.
By understanding thrombin's complex behavior, researchers can design more effective drugs and
treatments that target thrombin.