bluuebunny/crossref_metadata_2025 huggingface dataset:
The foraging activity of Carpenter bee, Xylocopa fenestrata on the major crops of
Eastern Rajasthan, India
Authors: Kachhawa Ghanshyam , Charan Santosh Kumar , Nagar Pankaj
Published: December 2020

The foraging activity of Xylocopa fenestrata was studied for analyzing its role in the pollination of plants to enhance crop production in the Chomu tehsil of Rajasthan, India. Xylocopa fenestrata were collected by hand sweeping net and by implanting artificial carpenter bee nests .The foraging activity of Xylocopa fenestrata showed mutualistic relationship with different plant species in the winter season in which Xylocopa fenestrata collected pollens and nectar from the flowers for nutrition and helped the plants in the pollination. Xylocopa fenestrata behaved differently with eight experimental plants on the basis of size, colour and odor of the flowers. It was found that foraging trip was affected by the different time intervals of the day on the basis of temperature, humidity and wind velocity. Xylocopa fenestrata visited on more flowers and spent least time per flower in the
noon to increase foraging trip. It was observed foraging activity was affected by the climatic factors and flower characters. Statistical data analysis by using MS Excel-2019, SPSS version-25 and R- confirmed the significance of experimental result
Validation of a sea lice dispersal model: principles from ecological agent-based models applied to aquatic epidemiology
Authors: Cantrell D , Vanderstichel R , Filgueira R , Grant J , Revie CW
Published: December 2020

Sea lice are one of the most economically costly and ecologically concerning problems facing the salmon farming industry. Here, we validated a coupled biological and physical model that simulated sea lice larvae dispersal from salmon farms in the Broughton Archipelago (BA), British Columbia, Canada. We employed a concept from ecological agent-based modeling known as ‘pattern matching’, which identifies similar emergent properties in both the simulated and observed data to confirm that the simulation contained sufficient complexity to recreate the emergent properties of the system. One emergent property from the biophysical simulations was the existence of sub-networks of farms. These were also identified in the observed sea lice count data in this study using a space-time scan statistic (SaTScan) to identify significant spatio-temporal clusters of farms. Despite finding support for our simulation in the observed data, which consisted of over a decade’s worth of monthly sea lice abundance counts from salmon farms in the BA, the validation was not entirely straightforward. The complexities associated with validating this biophysical dispersal simulation highlight the need to further develop validation techniques for agent-based models in general, and biophysical simulations in particular, which often result in patchiness in their dispersal fields. The methods utilised in this validation could be adopted as a template for other epidemiological dispersal models, particularly those related to aquaculture, which typically have robust disease monitoring data collection plans in place.
Glucagon-like peptide-1 receptor agonist reduces di(2-ethylhexyl) phthalate-induced atherosclerotic processes in vascular smooth muscle cells
Authors: Kim J.H.
Published: December 2020

Glucagon-like peptide-1 receptor (GLP1R) agonist is an incretin hormone and regulates glucose metabolism. However, phthalates, known as endocrine disruptors, can interfere with hormone homeostasis. In the present study, we aimed to estimate the impact of GLP1R agonist on di(2 ethylhexyl) phthalate (DEHP)-induced atherosclerosis. For this purpose, the effects of GLP1R agonist on various atherogenesis-related cellular processes and pathways were assessed in vascular smooth muscle cells (VSMCs). DEHP-induced cell proliferation and migration were significantly decreased by GLP1R agonist in VSMCs. Protein levels of matrix metalloproteinase (MMP)-2 and MMP-9 were significantly decreased in cells exposed to GLP1R agonist, compared with DEHP-treated cells. Expression levels of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 were also reduced in GLP1R agonist-treated cells. Similarly, DEHP-associated phosphorylation of protein kinase B and extracellular signal-regulated kinase 1/2 was decreased in GLP1R agonist-treated cells, compared with DEHP-treated cells. Our findings suggest that treatment with GLP1R agonist counteracts the activation of pathways related to atherosclerosis.
Efficacy and safety of autoprobiotic therapy in patients with type 2 diabetes mellitus
Authors: Simanenkov V. I. , Bakulina N. V. , Tikhonov S. V. , Ermolenko E. I. , Dekkanova V. D. , Kotyleva M. P. , Lavrenova N. S. , Voropaeva L. S. , Korzheva M. D. , Suvorov A. N. , Tsapieva A. N.
Published: December 2020

The original article presents the results of a study in which 12 patients with DM type 2 received 14-day therapy with an industrial probiotic (E. faecium L3 strains) or autoprobiotic (patient's own E. faecium). Therapy with the industrial probiotic and autoprobiotic had approximately the same effect on the severity of gastroenterological complaints and the quantitative/qualitative characteristics of the intestinal microbiota. In the group of E. faecium autostrain, there was a significant decrease of C-reactive protein.
Pathogenetic links of liver damage, obesity and COVID‑19
Authors: Bakulin I. G. , Bakulina N. V. , Tikhonov S. V. , Vinchuk S. A. , Dekkanova V. D. , Prokofiev N. A.
Published: December 2020

A retrospective analysis of 73 case histories of COVID‑19 patients were made to study the potential relationship between obesity, liver damage and COVID‑19. The average BMI of the study participants was 30.8 ± 5.8 kg/m2, waist circumference 103.5 ± 13.5 cm, 77 % of patients had abdominal obesity, 71 % of patients had cytolytic syndrome. There was not link between the presence of obesity and the level of transaminases. The degree of transaminases increase depended on the severity of COVID‑19 (level of ferritin, CRP, and oxygen saturation of the blood) and wasn't connected with BMI, waist circumference, and the presence of type 2 diabetes.
The Contagion Math
Authors: Dolgikh Serge
Published: December 2020

A comprehensive approach to mathematical modeling of an infectious epidemics development in time is outlined, that can be instrumental in developing specific models and provide insights into effective strategies and practices to containment and control of the contagion.
Antimicrobial Activity of Lemongrass Essential Oil (Cymbopogon flexuosus) and Its Active Component Citral Against Dual-Species Biofilms of Staphylococcus aureus and Candida Species
Authors: Gao Shanjun , Liu Guangzhi , Li Jianguo , Chen Jing , Li Lina , Li Zhen , Zhang Xiulei , Zhang Shoumin , Thorne Rick Francis , Zhang Shuzhen
Published: December 2020

Compared to mono-species biofilm, biofilms formed by cross-kingdom pathogens are more refractory to conventional antibiotics, thus complicating clinical treatment and causing significant morbidity. Lemongrass essential oil and its bioactive component citral were previously demonstrated to possess strong antimicrobial efficacy against pathogenic bacteria and fungi. However, their effects on polymicrobial biofilms remain to be determined. In this study, the efficacy of lemongrass (Cymbopogon flexuosus) essential oil and its bioactive part citral against dual-species biofilms formed by Staphylococcus aureus and Candida species was evaluated in vitro. Biofilm staining and viability test showed both lemongrass essential oil and citral were able to reduce biofilm biomass and cell viability of each species in the biofilm. Microscopic examinations showed these agents interfered with adhesive characteristics of each species and disrupted biofilm matrix through counteracting nucleic acids, proteins and carbohydrates in the biofilm. Moreover, transcriptional analyses indicated citral downregulated hyphal adhesins and virulent factors of Candida albicans, while also reducing expression of genes involved in quorum sensing, peptidoglycan and fatty acids biosynthesis of S. aureus. Taken together, our results demonstrate the potential of lemongrass essential oil and citral as promising agents against polymicrobial biofilms as well as the underlying mechanisms of their activity in this setting.
Roads and Road-Posts as an Ecological Trap for Cavity Nesting Desert Birds
Authors: Ben-Aharon Nimrod , Kapota Dror , Saltz David
Published: December 2020

While road-side productivity attracts wildlife, roads are also a major cause of mortality. Thus, roads are potentially an attractive sink. We investigated whether roads in a desert environment in southern Israel act as an ecological trap for the territorial mourning wheatear (Oenanthe lugens). We applied an individual-based mechanistic approach to compare the apparent survival of individually-marked wheatears between roadside territories and territories in natural habitats farther away from the road, and determined directionality in territorial shifting to and from the road. Analysis was based on mark-resight techniques and multi-model inference in a multi-strata approach (program MARK). Wheatear survival in road-side territories was too low to be compensated by the maximum possible recruitment, but shifted territories from natural habitat toward the roadside habitat as these territories were vacated by mortality. Vacated territories along the road were re-occupied faster than vacated territories in natural habitat. Thus, the roadside habitat in our study area fulfilled all conditions for an ecological trap. Roads may act as widespread ecological traps and their impact, therefore, may extend well-beyond the existing perception of narrow dissecting elements causing local mortality and/or animal avoidance. In species where habitat selection is based on contest competition (e.g., territorial species) and contest success has a genetically heritable component, ecological traps will induce a paradoxical selection process.
Gut Microbiota and Intestinal Epithelial Myd88 Signaling Are Crucial for Renal Injury in UUO Mice
Authors: Watanabe Ingrid Kazue Mizuno , Andrade-Silva Magaiver , Foresto-Neto Orestes , Felizardo Raphael José Ferreira , Matheus Marco Aurélio Costa , Silva Reinaldo Correa , Cenedeze Marcos Antônio , Honda Tâmisa Seeko Bandeira , Perandini Luiz Augusto Buoro , Volpini Rildo Aparecido , Pacheco-Silva Alvaro , Câmara Niels Olsen Saraiva
Published: December 2020

Increasing evidence shows the essential participation of gut microbiota in human health and diseases by shaping local and systemic immunity. Despite an accumulating body of studies showing that chronic kidney disease (CKD) is closely associated with disturbances in the composition of gut microbiota, it remains unclear the importance of gut microbiota in the onset and development of CKD. For the purpose of untangling the role of gut microbiota in CKD, gut microbiota was depleted with a pool of broad-spectrum antibiotics in mice submitted to unilateral ureteral obstruction (UUO). Depletion of gut microbiota significantly decreased levels of proinflammatory cytokines and fibrosis markers, attenuating renal injury. Additionally, to study whether the pathogenic role of gut microbiota is dependent of microbial-host crosstalk, we generated mice lacking Myd88 (myeloid differentiation primary response gene 8) expression in intestinal epithelial cells (IECs) and performed UUO. The absence of Myd88 in IECs prevented a bacterial burden in mesenteric lymph nodes as observed in WT mice after UUO and led to lower expression of proinflammatory cytokines and chemokines, reducing deposition of type I collagen and, ultimately, attenuating renal damage. Therefore, our results suggest that the presence of gut microbiota is crucial for the development of CKD and may be dependent of Myd88 signaling in IECs, which appears to be essential to maturation of immune cells intimately involved in aggravation of inflammatory scenarios.
Microvascular Fluid Exchange: Implications of the Revised Starling Model for Resuscitation of Dengue Shock Syndrome
Authors: Trung Dinh The , Trieu Huynh Trung , Wills Bridget A.
Published: December 2020

Dengue is the most common mosquito-borne viral infection in the world. The most feared complication is a poorly understood vasculopathy that occurs in only a small minority of symptomatic individuals, especially children and young adults, but can result in potentially fatal dengue shock syndrome (DSS). Based mainly on expert opinion, WHO management guidelines for DSS recommend prompt infusion of a crystalloid fluid bolus followed by a tapering crystalloid fluid regimen, supplemented if necessary by boluses of synthetic colloid solutions. However, following publication of a number of major trials undertaken in other, primarily adult, critical care scenarios, use of both synthetic colloid solutions and of fluid boluses for volume expansion have become controversial. Synthetic colloids tend to be used for severe DSS cases in order to boost intravascular oncotic pressure, based on the classic Starling hypothesis in which opposing hydrostatic and oncotic forces determine fluid flow across the microvascular barrier. However, the revised Starling model emphasizes the critical contribution of the endothelial glycocalyx layer (EGL), indicating that it is the effective oncotic pressure gradient across the EGL not endothelial cells per se that opposes filtration. Based on several novel concepts that are integral to the revised Starling model, we review the clinical features of DSS and discuss a number of implications that are relevant for fluid management. We also highlight the need for context-specific clinical trials that address crucially important questions around the management of DSS.
L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes
Authors: Shatanawi Alia , Momani Munther S. , Al-Aqtash Ruaa , Hamdan Mohammad H , Gharaibeh Munir N.
Published: December 2020

Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction. This dysfunction has been implicated in increasing the morbidity and mortality of T2DM patients. One of the important characteristics of vascular dysfunction is the impaired ability of endothelial cells to produce nitric oxide (NO). Additionally, decreases in the availability of NO is also a major contributor of this pathology. NO is produced by the activity of endothelial NO synthase (eNOS) on its substrate, L-arginine. Reduced availability of L-arginine to eNOS has been implicated in vascular dysfunction in diabetes. Arginase, which metabolizes L-arginine to urea and ornithine, competes directly with NOS for L-arginine. Hence, increases in arginase activity can decrease arginine levels, reducing its availability to eNOS and decreasing NO production. Diabetes has been linked to elevated arginase and associated vascular endothelial dysfunction. We aimed to determine levels of plasma NO and arginase activity in (T2DM) patients and the effects of L-citrulline supplementation, a natural arginase inhibitor, on inhibiting arginase activity in these patients. Levels of arginase correlated with HbA1c levels in diabetic patients. Twenty-five patients received L-citrulline supplements (2000 mg/day) for 1 month. Arginase activity decreased by 21% in T2DM patients after taking L-citrulline supplements. Additionally, plasma NO levels increased by 38%. There was a modest improvement on H1Ac levels in these patients, though not statistically significant. The effect of L-citrulline on arginase activity was also studied in bovine aortic endothelial cells (BAECs) grown in high glucose (HG) conditions. HG (25 mM, 72 h) caused a 2-fold increase in arginase activity in BAECs and decreased NO production by 30%. L-citrulline (2.5 mM) completely prevented the increase in arginase activity and restored NO production levels. These data indicate that L-citrulline can have therapeutic benefits in diabetic patients through increasing NO levels and thus maintaining vascular function possibly through an arginase inhibition related pathway.
Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity
Authors: Chang Mingxin , Wang Hongge , Niu Jiajing , Song Yan , Zou Zhihua
Published: December 2020

Background:Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels selectively in tumor cells, resulting in oxidative DNA damage to endanger cancer cell survival. However, DNA damage response signaling protects cancer cells by activating DNA repair and genome maintenance mechanisms. In this study, we investigated the synergistic effects of combining the pro-oxidative natural naphthoquinone alkannin with inhibition of DNA repair by PARP inhibitors.

Methods and Results:The results showed that sublethal doses of alkannin induced ROS elevation and oxidative DNA damage in colorectal cancer but not normal colon epithelial cells. Blocking DNA repair with the PARP inhibitor olaparib markedly synergized with alkannin to yield synergistic cytotoxicity in colorectal cancer cells at nontoxic doses of both drugs. Synergy between alkannin and olaparib resulted from interrupted repair of alkannin-induced oxidative DNA damage and PARP-trapping, as it was significantly attenuated by NAC or by OGG1 inhibition and the non-trapping PARP inhibitor veliparib did not yield synergism. Mechanistically, the combination of alkannin and olaparib caused intense replication stress and DNA strand breaks in colorectal cancer cells, leading to apoptotic cancer cell death after G2arrest. Consequently, coadministration of alkannin and olaparib induced significant regression of tumor xenograftsin vivo, while each agent alone had no effect.

Conclusion:These studies clearly show that combining alkannin and olaparib can result in synergistic cancer cell lethality at nontoxic doses of the drugs. The combination exploits a cancer vulnerability driven by the intrinsic oxidative pressure in most cancer cells and hence provides a promising strategy to develop broad-spectrum anticancer therapeutics.
Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease
Authors: Al-Bachari Sarah , Naish Josephine H. , Parker Geoff J. M. , Emsley Hedley C. A. , Parkes Laura M.
Published: December 2020

Background

Blood–brain barrier (BBB) disruption has been noted in animal models of Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.

Objective

To determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease.

Methods

Dynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB (Ktrans) and plasma volume (vp) were produced using Patlak analysis. Differences in Ktrans and vp were assessed with voxel-based analysis as well as in regions associated with PD pathophysiology. In addition, the volume of white matter lesions (WMLs) was obtained from T2-weighted fluid attenuation inversion recovery (FLAIR) images.

Results

Higher Ktrans, reflecting higher BBB leakage, was found in the PD group than in the CN group using voxel-based analysis; differences were most prominent in the posterior white matter regions. Region of interest analysis confirmed Ktrans to be significantly higher in PD than in CN, predominantly driven by differences in the substantia nigra, normal-appearing white matter, WML and the posterior cortex. WML volume was significantly higher in PD compared to CN. Ktrans values and WML volume were similar in PD and CP, suggesting a similar burden of cerebrovascular disease despite lower cardiovascular risk factors.

Conclusion

These results show BBB disruption in PD.
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19
Authors: Sanino Giulia , Bosco Martino , Terrazzano Giuseppe
Published: December 2020

SARS-CoV2 infection not only causes abnormal severe pneumonia but also induces other relevant pathophysiological effects on several tissues and organs. In this regard, the clinical complications observed in COVID-19 include acute coronary syndrome, pulmonary thromboembolism, myocarditis and, in the severe cases, the occurrence of disseminated intravascular coagulation. Literature on COVID-19 highlighted the central role of the Renin Angiotensin Aldosterone System in the determinism of SARS-CoV2 cellular internalization in the target tissues. Lung degeneration and respiratory distress appear to be dependent on the perturbance of physiological mechanisms, such as the uncontrolled release of pro-inflammatory cytokines, a dysregulation of the fibrinolytic coagulative cascade and the hyperactivation of immune effector cells. In this mini review, we address the physiology of Midkine, a growth factor able to bind heparin, and its pathophysiological potential role in COVID-19 determinism. Midkine increases in many inflammatory and autoimmune conditions and correlates with several dysfunctional immune-inflammatory responses that appear to show similarities with the pathophysiological elicited by SARS-CoV2. Midkine, together with its receptor, could facilitate the virus entry, fostering its accumulation and increasing its affinity with Ace2 receptor. We also focus on Netosis, a particular mechanism of pathogen clearance exerted by neutrophils, which under certain pathological condition becomes dysfunctional and can cause tissue damage. Moreover, we highlight the mechanism of autophagy that the new coronavirus could try to escape in order to replicate itself, as well as on pulmonary fibrosis induced by hypoxia and on the release of cytokines and mediators of inflammation, correlating the interplay between Midkine and SARS-CoV2.
Identification of Chromosomes and Chromosome Rearrangements in Crop Brassicas and Raphanus sativus: A Cytogenetic Toolkit Using Synthesized Massive Oligonucleotide Libraries
Authors: Agrawal Neha , Gupta Mehak , Banga Surinder S. , Heslop-Harrison JS (Pat)
Published: December 2020

Crop brassicas include three diploid [Brassica rapa(AA; 2n= 2x= 16),B. nigra(BB; 2n= 2x= 18), andB. oleracea(CC; 2n= 2x= 20)] and three derived allotetraploid species. It is difficult to distinguishBrassicachromosomes as they are small and morphologically similar. We aimed to develop a genome-sequence based cytogenetic toolkit for reproducible identification ofBrassicachromosomes and their structural variations. A bioinformatic pipeline was used to extract repeat-free sequences from the whole genome assembly ofB. rapa. Identified sequences were subsequently used to develop four c. 47-mer oligonucleotide libraries comprising 27,100, 11,084, 9,291, and 16,312 oligonucleotides. We selected these oligonucleotides after removing repeats from 18 identified sites (500–1,000 kb) with 1,997–5,420 oligonucleotides localized at each site inB. rapa. For one set of probes, a new method for amplification or immortalization of the library is described. oligonucleotide probes produced specific and reproduciblein situhybridization patterns for all chromosomes belonging to A, B, C, and R (Raphanus sativus) genomes. The probes were able to identify structural changes between the genomes, including translocations, fusions, and deletions. Furthermore, the probes were able to identify a structural translocation between a pak choi and turnip cultivar ofB. rapa.Overall, the comparative chromosomal mapping helps understand the role of chromosome structural changes during genome evolution and speciation in the family Brassicaceae. The probes can also be used to identify chromosomes in aneuploids such as addition lines used for gene mapping, and to track transfer of chromosomes in hybridization and breeding programs.
Recycling Nutrient Solution Can Reduce Growth Due to Nutrient Deficiencies in Hydroponic Production
Authors: Miller Alexander , Adhikari Ranjeeta , Nemali Krishna
Published: December 2020

It is common in hydroponics to supply nutrients to crops by maintaining electrical conductivity (EC) of the recycling solution at a target level. Levels of individual nutrients in the solution are generally not assessed as their regular measurement and adjustment can be both expensive and technically challenging. However, the approach of growing crops at a target EC can potentially result in nutrient imbalances in the solution and reduced growth. We quantified the effects of recycling on solution EC changes, tissue nutrient concentration, canopy growth rate, plant water status, and shoot and root weight of lettuce (Lactuca sativa) in a greenhouse. The tap water quality was moderately alkaline and similar to that commonly observed in many commercial greenhouses. In our research, recycling solution maintained at a target EC (1.8 dS⋅m–1) significantly reduced shoot fresh (22–36%) and dry weight compared to the control supplied regularly with freshly prepared solution at the target EC. Further, recycling significantly decreased N, P, K, and Fe and increased Na and Cu levels in the tissue, in addition to increasing solution EC between adjustments compared to the control. Using image analysis of groups of plants, we identified that the negative effects of recycling on canopy area started 2 weeks after transplanting. Based on these results, we hypothesized that certain unwanted compounds (e.g., bicarbonates) and slowly consumed elements (e.g., Ca, Mg) were added to the recycling solution through the alkaline tap water with time. Their accumulation “artificially” increased solution EC and “masked” the lower than optimal levels of major nutrients in the solution, leading to the reductions in the concentration of nutrients in the tissue and plant growth. Supporting this, the negative effects of recycling were not observed when the recycling solution was either discarded after 2 weeks of use or made using reverse osmosis water and continuously used. Our findings aid in proper management of recycling solution in hydroponic lettuce production.
Co-emergence Reinforcement and Its Relevance to Interoceptive Desensitization in Mindfulness and Therapies Aiming at Transdiagnostic Efficacy
Authors: Cayoun Bruno A. , Shires Alice G.
Published: December 2020

Interoception, the ability to feel the body’s internal sensations, is an essential aspect of emotional experience. There is mounting evidence that interoception is impaired in common mental health disorders and that poor interoceptive awareness is a major contributor to emotional reactivity, calling for clinical interventions to address this deficit. The manuscript presents a comprehensive theoretical review, drawing on multidisciplinary findings to propose a metatheory of reinforcement mechanisms applicable across a wide range of disorders. We present a reconsideration of operant conditioning through the co-emergence model of reinforcement, which is a neurophenomenological account of the interaction between cognition and interoception, and its consequences on behavior. The model suggests that during memory processing, the retrieval of autobiographical memory (including maladaptive cognition) is dependent upon its co-emerging interoceptive cues occurring at the encoding, consolidation and reconsolidation stages. Accordingly, “interoceptive reinforcement” during emotional distress is a common factor to all emotional disorders and a major cause for relapse. We propose that interoceptive desensitization has transdiagnostic benefits, readily achievable through the cultivation of equanimity during mindfulness training and can be integrated in cognitive and behavioral interventions to permit a transdiagnostic applicability. We summarize the contributions of this approach into 10 specific and testable propositions.
The Juggernaut of Modernity Collapses. The Crisis of Social Planification in the Post COVID-19 era
Authors: Lusardi Roberto , Tomelleri Stefano
Published: December 2020

This article arises from the urgent need to reflect on the current situation resulting from the dramatic consequences of a crisis which appears to be epochal and which, as sociologists, questions us at first hand. This is to understand the socio-cultural, economic and technological processes that triggered it and to attempt to imagine future scenarios. At the dawn of the third millennium, it seems as if the juggernaut of modernity, with its dream of unlimited progress and cargo of unconditional trust in instrumental rationality, has abruptly slowed down. The pandemic challenges contemporary society to develop a differentweltanschauung, alternative to the performative and conformist idea of social planification supported by the neoliberal paradigm. It compels us to finally acquire the consciousness that the complexity of knowledge and global interdependency require collective awareness, political participation, and shared responsibility.
ПРОГРАММА ТЕСТИРОВАНИЯ С МУЛЬТИМЕДИЙНЫМИ
КОМПОНЕНТАМИ НА ОСНОВЕ WPF
Authors:   Жамалова В.Ж., Каримбаев Т.Т., Раймжанова Ф.Р., Сатаров Э.
Published: December 2020

В статье рассматривается применение технологии WPF для создания
тестирующей программы с мультимедийными компонентами занятий студентов физкультурников
ANALISIS INOVASI PENGEMBANGAN ORGANISASI PADA PEMERINTAH DESA WUKIRSARI KABUPATEN SLEMAN
Authors: Nugroho Hanantyo Sri , Rahmawati Agustina
Published: December 2020

Studi ini mengkaji faktor-faktor keberhasilan dari pengembangan organisasi pada pemerintahan desa. Sasaran penelitian ini adalah inovasi sistem administrasi pemerintahan, inovasi sistem pelayanan masyarakat, inovasi ekonomi wisata, inovasi bidang pendidikan di Pemerintah Desa Wukirsari Kabupaten Sleman. Dalam memahami proses inovasi tersebut, peneliti menggunakan teori implementasi inovasi. Titik tekan teori tersebut adalah faktor individu, faktor struktur dan faktor budaya. Artinya, strategi inovasi pengembangan organisasi Pemerintah Desa Wukirsari dapat dilihat dari bagaimana individu yang ada pada pemerintah desa dan masyarakat desa tersebut berjalan dengan baik, maka dapat memengaruhi struktur dan budaya yang ada. Hasil penelitian adalah pelaksanaan inovasi pengembangan organisasi secara elektronik dapat meningkatkan kecakapan pemerintah desa dan masyarakat Desa Wukirsari. Adapun, beberapa inovasi program pelayanan publik tersebut, yakni inovasi sistem administrasi pemerintahan berupa Sistem Data Administrasi Kependudukan (Sidampak), inovasi sistem pelayanan masyarakat berupa sistem Lukadesi, Ulangtahunku dan Sidanik, inovasi ekonomi dan wisata berupa program konservasi burung hantu, Tyto Alba, inovasi bidang pendidikan berupa program sekolah pintar.

Kata kunci: Pengembangan Organisasi, Inovasi sistem administrasi pemerintahan, Inovasi sistem pelayanan masyarakat, Inovasi ekonomi wisata, Inovasi bidang pendidikan.
PERAN LEMBAGA ADAT KAMPUNG KUTA DALAM PELESTARIAN LINGKUNGAN HIDUP BERBASIS KEARIFAN LOKAL DI KABUPATEN CIAMIS
Authors: Suwarlan Erlan
Published: December 2020

Abstrak

Potensi ancaman terhadap wilayah adat bisa terjadi di mana pun, tidak terkecuali pada wilayah adat kampung Kuta yang notabene selama ini memberi kontribusi terhadap pelestarian lingkungan hidup yang ada di Ciamis. Tujuan dari penelitian ini untuk menganalisis peran lembaga adat Kampung Kuta yang dikenal sebagai kampung “seribu” larangan dalam mempertahankan nilai-nilai dan tradisi untuk melestarikan lingkungan hidup. Metode kualitatif digunakan untuk mengeksplorasi informasi guna memperoleh kejelasan makna dari setiap peran yang ditunjukkan oleh para aktor dalam melestarikan lingkungan hidup berbasis kearifan lokal. Pengujian keabsahan data dilakukan dengan menggunakan teknik triangulasi. Hasil penelitian menunjukkan bahwa peran Lembaga Adat Kampung Kuta dalam merencanakan pesan berawal dari nilai-nilai yang diwariskan secara turun-temurun dengan istilah “pamali. Nilai ini sangat efektif dan secara khusus memiliki implikasi positif dalam pelestarian lingkungan hidup. Kemudian peran dalam membuat pesan penyadaran masyarakat dalam melestarikan lingkungan hidup tertuang dalam nasihat-nasihat yang berkembang dari mulut ke mulut yang diwariskan dari para leluhur. Selanjutnya peran dalam menyampaikan pesan berbasis dari keluarga sehinga nilai-nilainya bisa ditanamkan sejak dini. Peran Komunitas Adat dalam mempraktikkan nilai-nilai sesungguhnya ada dalam seluruh aspek kehidupan, secara khusus peran kuncen dalam menjaga hutan keramat atau Leuweung Gede sangat menentukan dan berpengaruh terhadap kelestariannya sampai saat ini. Secara keseluruhan empat peran dalam melestarikan lingkungan hidup berbasis nilai-nilai kearifan lokal diperankan oleh kuncen, sesepuh, dan ketua adat.

 

Kata Kunci: Peran, Lembaga Adat, Lingkungan Hidup, Kearifan Lokal.
Tradução comentada do proêmio de Medicamina Faciei Femineae, de Ovídio
Authors: De Brito Viana Marques Tassiana , Hozanete Alves de Lima Maria
Published: December 2020

Este trabalho tem como objetivo apresentar uma tradução do proêmio do texto Medicamina Faciei Femineae, do poeta latino Ovídio. Circunscrito na literatura pelo seu caráter didático, o texto ovidiano recebeu, ao longo do tempo, pouca atenção da crítica literária, o que não aconteceu com outras obras, a exemplo da “Arte de Amar”. Elegemos o proêmio do texto Medicamina Faciei Femineae para traduzir e comentar sobre a  presença da puella romana e de outras mulheres, às quais o autor faz referência. Refletimos, ainda, sobre certas analogias estabelecidas no texto ovidiano que parecem oferecer credibilidade aos ensinamentos por ele propostos.
Traduzindo o luto: o lamento materno em Suplicantes de Eurípides
Authors: Almeida Vanessa Silva , De Araújo Orlando Luiz
Published: December 2020

Este trabalho objetiva fazer uma breve análise do lamento enlutado das mães argivas no coro de Suplicantes, de Eurípides, e verificar como as imagens e os sentidos desse lamento construídos no texto-fonte podem ser reconstruídos na tradução para o português brasileiro. Para isso, traduzimos opárodo da peça (v. 42-86), bem como o trecho entre os versos 798 e 836, em que o luto e as manifestações de lamento são mais visíveis. Considerou-se como ponto de partida o emprego das palavras thrḗnos, góos e kommós na literatura grega para então desenvolvermos a análise do lamento na peça em questão. Embasamo-nos, principalmente, em Alexiou (2002) e Loraux (1994). Ao final, conclui-se que são as escolhas lexicais feitas que asseguram a percepção dos sentidos e imagens do texto-fonte no texto traduzido através da análise de elementos cênicos.
Dáfnis e Cloé, de Longo de Lesbos - Livro segundo: tradução e comentário
Authors: Mangia Silva Luiz Carlos Andre
Published: December 2020

Apresentamos aqui a tradução para a língua portuguesa da segunda parte do romance de Longo de Lesbos, intitulado Dáfnis e Cloé, datado de meados do século II d.C. Também conhecida como As Pastorais, a obra não dispõe ainda de tradução integral em português feita diretamente da língua grega. Assim, nossa tradução pretende sanar esta carência e permitir ao leitor um contato mais seguro com o texto original. Nesta segunda parte do romance, podemos ver diferentes ações, entre as quais Dáfnis e Cloé ajudando nos trabalhos ligados à colheita da uva; o incidente com os jovens estrangeiros, que acabam por mover guerra contra os protagonistas; a intervenção guerreira do deus Pã, irritado com a ousadia dos estrangeiros; e finalmente, a celebração dos personagens com banquete e apresentações artísticas.
The introduction of the moral psychology in the ergon argument
Authors: Pires de Oliveira Angelo Antonio
Published: December 2020

In this paper, I discuss in detail one of the first conclusions drawn by Aristotle in the ergon argument. The paper provides an in-depth approach to Nicomachean Ethics’ lines 1098a3-4, where one reads: “λείπεται δὴ πρακτική τις τοῦ λόγον ἔχοντος”. I divide the discussion into two parts. In the first part, I put under scrutiny how one should take the word “πρακτική” and argue that one should avoid taking this word as meaning “practical” in the passage. I will argue in favor of taking it as meaning “active”. The exegetical inconvenience of taking “πρακτική” as meaning “practical” is the fact that it restricts the results achieved in the ergon argument by excluding the possibility of contemplation being considered a eudaimon life. In the second part, I discuss the expression “λόγον ἔχον” and provide some arguments to take it as preliminarily introducing the criterion of division of the virtues that will be spelled out in EN I.13 so that the λόγον-ἔχον part of the soul here also makes reference to the virtue of the non-rational part, i.e., virtue of character. I offer a deflationary view by showing that the moral psychology is developed in EN I.7 within the limits imposed by the ergon argument.
A linhagem dos heróis na cosmologia hesiódica
Authors: Oliveira Juarez
Published: December 2020

Este trabalho discute a figura do ἥρως na poesia hesiódica a fim de entender em que consistem o herói e a chamada linhagem dos heróis na cosmologia apresentada por Hesíodo. Para isso, partindo da definição de herói, proposta por Gregory Nagy, como alguém, homem ou mulher, que descende de deuses e mortais, realiza-se uma análise filológica das passagens da Teogonia, do Catálogo das Mulheres e de Trabalhos e Dias em que o termo ἥρως é usado. Mostra-se que o herói é um personagem que pode exercer as funções de fundador, rei e guerreiro, sem que elas sejam mutuamente excludentes,  vive em cidades e pratica guerra e navegação, além da agricultura. Enquanto membro da chamada linhagem dos heróis, ele está destinado a morrer, especialmente nas guerras de Tebas e de Troia.
An Analysis of Tess of the D’Urbervilles from the Tragedy of Tess
Authors: Chen Desheng , Shi Xuewei
Published: December 2020

Thomas Hardy was a very famous and the last important novelist of the Victorian age in England, his novels and poems have a great influence in the literature in 20 century. Tess of the D’Urbervilles is the most influential one among his works. This novel describes a miserable and hard life of one beautiful and pure girl named Tess after being seduced. The article reveals the society environment, the peasant poverty family, the inequality of gender and the false moral value at that time by describing Tess’ life. Tess’ tragic life is caused by many factors and it’s the result of the burden of society. Except this, her own weakness in character cannot be separated from her tragedy, because she obviously has the dual nature — resistance and compromise, which seems like the nature of many women. As a poor peasant girl, Tess once tried to fight with destiny, but she failed. In the end, she turned out to be a murderer and also the victim of society like all other things which disobey the rules at that time. Eventually, she was separated from her lover and hanged. A beautiful and pure girl came to such a miserable life and tragic ending.
Manfaat Rendaman Air Hangat dan Garam dalam Menurunkan Derajat Edema Kaki Ibu Hamil Trimester III
Authors: Sawitry Sawitry , Ulya Fitria Hikmatul , Adepatiloy Elisabet Jemsi
Published: December 2020

ABSTRAK Edema kaki terjadi hampir 80% dari semua kehamilan dan dapat menimbulkan ketidaknyamanan selama kehamilan seperti nyeri, merasa berat, kram pada malam hari, penebalan kulit, dan pigmentasi. Salah satu intervensi non farmakologis untuk mengurangi edema adalah rendaman air hangat dan garam yang merupakan intervensi untuk menghilangkan edema pada ekstremitas bawah  selama kehamilan. Menganalisis  pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Penelitian kuantitatif dengan metode quasy eksperimental one group pre test post test desaign. Sampel penelitian sebanyak 16 ibu hamil Trimester III dengan teknik accidental sampling. Analisis data menggunakan uji Wilcoxon. Terjadi penurunan tingkat edema kaki pada ibu hamil dengan selisih nilai tengah edema kaki sebelum 4,00 dan setelah perlakuan sebesar 0,00  .Uji Wilcoxon menunjukkan ρ value 0,000. Ada pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Kata Kunci : rendaman air hangat dan garam; edema; tungkai bawah ; ibu hamil.  THE EFFECT OF WARM WATER AND SALT IMMERSION IN DECLINING LEG EDEMA OF THIRD TRIMESTER PREGNANT WOMEN  ABSTRACT Edema of the legs occurs in almost 80% of all pregnancies and can cause discomfort during pregnancy such as pain, feeling heavy, cramps at night, skin thickening, and pigmentation. One of the non-pharmacological interventions to reduce edema is soaking in warm water and salt which is an intervention to relieve edema in the lower extremities during pregnancy. This study was to determine the effect of warm water and salt immersion in declining leg edema of third trimester pregnant women. This quantitative research used quasy experimental method one group pre test post test desaign. The total samples were 16 respondents with purposive sampling and random sampling techniques. Data analysis used the Wilcoxon test. The difference in the mean value of leg edema before 4.00 and after treatment was 0.00. The Wilcoxon test showed ρ value of 0.000. There is an effect of warm water and salt immersion on leg edema of third trimester pregnant women.   Keywords: warm water and salt soaking; edema; lower limbs; pregnant mother
Hubungan Perilaku Makan dengan Status Gizi pada Remaja Putri di SMAN 2 Tambang
Authors: Ratih Rini Hariani
Published: December 2020

ABSTRAK Data Riskesdas 2018 menunjukkan bahwa 25,7% remaja usia 13-15 tahun dan 26,9% remaja usia 16-18 tahun dengan status gizi pendek dan sangat pendek. Selain itu terdapat 8,7% remaja usia 13-15 tahun dan 8,1% remaja usia 16-18 tahun dengan kondisi kurus dan sangat kurus. Sedangkan prevalensi berat badan lebih dan obesitas sebesar 16,0% pada remaja usia 13-15 tahun dan 13,5% pada remaja usia 16-18 tahun. Data tersebut merepresentasikan kondisi gizi pada remaja di Indonesia yang harus diperbaiki. Berdasarkan baseline survey UNICEF pada tahun 2017, ditemukan adanya perubahan pola makan dan aktivitas fisik pada remaja. Gizi merupakan salah satu faktor utama penentu kualitas hidup dan sumber daya manusia. Tujuan penelitian Untuk mengetahui hubungan perilaku makan terhadap status gizi pada siswi SMAN 2 Tambang 2018. Penelitian ini mengunakan jenis kuantitatif analitik dengan desain cross sectional.  Populasi pada penelitian ini adalah seluruh siswa putri SMAN 2 Tambang dari kelas XI sebanyak 240 orang  dengan sampel sebanyak 71 orang. Hasil uji Chi Square didapatkan nilai p=0,01 (≤ 0,05. Ada hubungan yang signifikan perilaku makan dengan status gizi pada remaja putr di SMAN 2 Tambang.Kata Kunci : perilaku makan; status gizi;  remaja putri  RELATIONSHIP BETWEEN EATING BEHAVIOR WITH NUTRITIONAL STATUS IN FEMALE ADOLESCENT AT TAMBANG STATE SENIOR HIGH SCHOOL 2 ABSTRACT  According to the report of Indonesian Health Research in 2018 showed that 25.7% of adolescents aged 13-15 years and 26.9% of adolescents aged 16-18 years have a short and very short nutritional status. In addition, there were 8.7% adolescents aged 13-15 years and 8.1% adolescents aged 16-18 years with thin and very thin conditions. Meanwhile, the prevalence of overweight and obesity was 16.0% in adolescents aged 13-15 years and 13.5% in adolescents aged 16-18 years. Nutrition is one of the main factors determining the quality of life and human resources. Nutrients are chemicals found in food that the body needs to maintain health and immunity; adolescents are one of the groups that are prone to experiencing nutritional problems. The research objective was to determine the relationship between eating behavior and the nutritional status of students at SMAN 2 Tambang 2018. This research method used a quantitative analytic research type, with a cross sectional study design. The populations in this study were all 12 students of Tambang State Senior High School 2 from class XI totaling 240 students. The sample in this study was some of the 71 class students. The results of the Chi Square test showed that the value of p = 0.01 (≤ 0.05), this means that statistically there is a relationship between eating behavior and nutritional status in young girls. Keywords: eating behavior; nutritional status; female adolescent
Analisis Kesiapan Bidan dalam Pelaksanaan Pelayanan Kebidanan Komplementer
Authors: Jumiatun Jumiatun , Nani Shinta Ayu
Published: December 2020

ABSTRAK Terapi komplementer merupakan terapi yang bertujuan untuk melengkapi pengobatan medis konvensional. Penyelenggaraan terapi komplementer telah diatur dalam Permenkes RI Nomor 1109 Tahun 2007 tentang penyelenggaraan pengobatan komplementer alternatif di fasilitas pelayanan kesehatan. Menjadi peluang bagi bidan untuk mengembangkan profesionalisme dalam pelaksanaan praktik kebidanan secara lebih komprehensif, dapat menambah nilai jual praktik kebidanan dalam memberikan pelayanan kepada masyarakat dan sebagai salah satu cara meningkatkan daya saing pasar, nilai tambah, unggulan, inovatif dan sesuai dengan harapan dari pengguna jasa layanan kebidanan. Tujuan penelitian ini untuk menganalisis faktor-faktor yang berpengaruh terhadap kesiapan bidan dalam pelaksanaan pelayanan kebidanan komplementer di IBI ranting Weleri Kabupaten Kendal. Jenis penelitian survey analitik dengan pendekatan cross sectional, sampel diambil secara proporsional sejumlah 78 bidan di IBI ranting Weleri, instrument penelitian menggunakan kuesioner. Hasil analisa data regresi sederhana menunjukkan p value 0,569 (kemampuan), 0,000 (self efficacy). Tidak ada pengaruh kemampuan terhadap kesiapan dan  ada pengaruh self efficacy terhadap kesiapan. Kata kunci: kebidanan komplementer; kemampuan; kesiapan; self efficacy  ANALYZE THE FACTORS THAT INFLUENCE THE READINESS OF MIDWIVES IN IMPLEMENTING COMPLEMENTARY  ABSTRACT Complementary therapy is a therapy that aims to complement conventional medical treatment. Implementation of complementary therapy has been regulated in the Republic of Indonesia Minister of Health Regulation Number 1109 of 2007 concerning Implementation of Alternative Complementary Medicine in Health Service Facilities. it can be an opportunity for midwives to develop professionalism in implementing midwifery practice more comprehensively, it can also add value to midwifery practice in providing services to the community and as a way to increase market competitiveness, added value. , superior, innovative and in accordance with the expectations of users of midwifery services. The purpose of this study was to analyze the factors that influence the readiness of midwives in implementing complementary midwifery services at IBI Weleri branch, Kendal Regency. This type of analytic survey research with a cross sectional approach, the sample was taken proportionally a number of 78 midwives at IBI Weleri branch, the research instrument was used a questionnaire method. The results of simple regression data analysis showed p value 0.569 (ability), 0.000 (self efficacy). There is no effect of ability on readiness, there is an effect of self-efficacy on readiness. Key words: complementary midwifery ability; readiness; self efficacy