bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Modelling and in Vitro Hypoglycemic Examination of Polysubstituted Quinoline Derivatives
Authors:   Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, India., Angajala Gangadhara , Aruna Valmiki ,   Chemistgry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, India., Subashini Radhakrishnan ,   Chemistry, Arignar Anna Government Arts College for women, Walajapet-632513, India., Das Geetha ,   Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, India., Rajajeyaganthan Ramanathan ,   Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar, India.
Published: January 2020

In the present work in-silico molecular simulations were carried out to find out the binding affinities of synthesized polysubstituted quinolines towards PPARγ protein (2XKW). The results obtained from docking analysis showed that the synthesized polysubstituted quinoline derivatives 1a-g are having stronger binding interactions which was on par to that of standards rosiglitazone and pioglitazone. In addition to this in-vitro hypoglycemic studies were studied through α-amylase and α-glucosidase enzyme inhibition assays. The results showed that compounds 1c and 1d possess good hypoglycemic efficacy with percentage inhibition of 87.94 ± 0.25, 85.90 ± 0.56 towards α-glucosidase and 84.55 ± 1.02, 82.14 ± 0.26 percent inhibition towards α-amylase which was greater than standard rosiglitazone and comparable to standard pioglitazone
Nano SiC Reinforced Copper Nanocomposite by a Simple Electrodeposition Method
Authors:   Department of Chemistry, School of Advanced Sciences,Kalasalingam Academy of Research and Education(Deemed to be University), Krishnankoil-626126. Tamil Nadu, India., Ramalingam S.
Published: January 2020

The Cu and Cu-SiCnanocomposite coatings were prepared by a simple electrodeposition technique from acidic copper sulphate electrolyte using SiC nanoparticles with an average particles size of 50 nm under optimized bath composition and preparation conditions for possible electrical contact material applications such as electrical switch and wiring boards where higher electrical conductivity and thermal conductivity is required. The scope of the present study is to enhance the strength, mechanical, corrosion and wear resistance properties of Cu-SiCnanocomposite compared to pure Cu coatings. The as prepared Cu and Cu-SiCnanocomposites were characterized for structural, mechanical and corrosion resistance properties by EDX, XRD, FESEM, Vickers microhardness tester and AC-impedance and Tafel polarization techniques. The elemental composition (wt% of Cu and SiC nanoparticles) of Cu-SiCnanocomposites was analyzed by EDX coupled with FESEM analysis confirms the presence of nanoSiC in the copper matrix and they were 89wt% of Cu and 11 wt% of SiC nanoparticles respectively. The surface morphology of Cu and Cu-SiCnanocomposites was studied by FESEM analysis shows that SiC nanoparticles were uniformly dispersed in the surface of the copper matrix compared to pure copper. The crystallite structure and grain size of the Cu and Cu-SiCnanocomposite electrodeposits was measured by XRD analysis. From the XRD results, the grain size calculated using Debye-Scherrer’s formula was ~35 nm for pure Cu and ~33 nm Cu-SiCnanocomposite. The crystallite structure of Cu and Cu-SiCnanocomposites was fcc (face centered cubic) and the preferred orientation of the plane was (220). The microhardness of Cu-SiCnanocomposite coating increased with increasing SiC nanoparticles concentration in the bath compared to pure Cu coating. The corrosion resistance measurements were performed for the pure Cu and Cu-SiCnanocomposite coatings by electrochemical impedance spectroscopy (EIS) and Tafel polarization techniques. It shows that, Cu-SiCnanocomposites has high corrosion resistance than pure Cu in 3.5wt% NaCl solution.
Structural and Photocatalytic Analysis of Niwo4 Materials
Authors:   Department of Physics, International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India., Kumar S. Saravana , Sivaganesh D. ,   Department of Physics, International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India., Kumar S. Sasi ,   Department of Physics, International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India., Arunpandian M. ,   Department of Chemistry, International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India., Archana R. ,   Department of Physics, International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India.
Published: January 2020

The different pH levels of NiWO4 materials were synthesized by co-precipitation route. The insight unit cell properties were studied by Powder X-ray diffraction (PXRD). The detailed structural analyses were done by Rietveld profile refinement method. The morphology on the surface of the synthesized NiWO4 materials was evaluated by scanning electron microscopic images. The presence of elements in the prepared materials were confirmed by energy dispersive X-ray spectroscopy (EDS) analysis. The photocatalytic activities of prepared materials are performed on methylene blue which is degraded by irradiation of catalyst in 50 minutes under ultra violet light.
Density Functional Theory Analysis of Poly Glycolic Acid with Metal Ions (Na+, K+) Interaction
Authors:   Department of Physics and International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil-626 126, India., Ganesan Mahendiraprabu , Paranthaman Selvarengan ,   Department of Physics and International Research Centre, Kalasalingam Academy of Research and Education, Krishnankoil-626 126, India.
Published: January 2020

The complexation between Poly glycolic acid (PGA) and alkali metal ions (Na+, K+) have been studied using B3LYP/6-311++G** method. The binding site of metal ion interaction on PGA is carbonyl oxygen. Both metal ions form bidendate complexation with PGA. Further, it can be noted that the PGA with K+ complex is more stable than the PGA with Na+ complex. The binding affinities (ΔH), basicity (ΔG) and the complexation entropies (ΔS) of all the studied systems are calculated. The interaction energy is maximum in PGA-Na+ than the PGA-K+ complex. This is due to more charge transfer taking place between PGA and Na. The stability of the complex is studied by the chemical hardness value. The condensed Fukui functions are calculated and are used to predict the favourable reactive site.
Pseudocapacitive Behavioral Testing of Iron Vanadate Nanoparticles Synthesized by Simple Co- Precipitation Method
Authors:   Department of Physics, Kalasalingam Academy of Research and Higher Education, Krishnankoil, Tamil Nadu 626126, India., Arasi S. Ezhil , Devendran P. ,   Department of Physics, Kalasalingam Academy of Research and Higher Education, Krishnankoil, Tamil Nadu 626126, India., Ranjithkumar R. ,   Department of Physics, Kalasalingam Academy of Research and Higher Education, Krishnankoil, Tamil Nadu 626126, India., Krishnakumar M. ,   Department of Physics, Kalasalingam Academy of Research and Higher Education, Krishnankoil, Tamil Nadu 626126, India., Arivarasan A. ,   Department of Physics, Kalasalingam Academy of Research and Higher Education, Krishnankoil, Tamil Nadu 626126, India.
Published: January 2020

Iron vanadate nanoparticles were prepared by simple co-precipitation method. The crystal structure and elemental composition of prepared material were confirmed using X-ray Diffraction analysis and Elemental Dispersive X- ray spectroscopic analysis respectively. Surface morphology of the sample was analyzed by Scanning Electron Microscopic techniques. Optical absorption and molecular vibrations were studied by UV-Vis. absorption spectroscopy and Fourier Transform Infrared spectroscopic techniques. Electrochemical behaviors such as redox property, charge-discharge mechanism and impedance analysis were examined with cyclic voltammetry, Galvanostatic charge-discharge and electrochemical impedance spectroscopic studies.
Current approaches to prophylaxis and treatment of travelers’ diarrhea
Authors: Andreeva Irina V. , Stetsiouk O.U. Olga U.
Published: January 2020

Travelers’ diarrhea is the most common infectious disease in this subpopulation and usually develops within the first week of travel. This review presents summarized data on epidemiology and etiology of travelers’ diarrhea. Nonspecific precautions and medical treatments (antimicrobials, probiotics) to prevent this infection are described in detail. Current approaches to the treatment of travelers’ diarrhea (oral rehydration, probiotics, anti­diarrheals, antimicrobials) in adults and children depending on disease severity are also considered.
Animales domésticos como reservorio de Escherichia coli Productor de Toxina Shiga en Mar del Plata
Authors: Zotta Claudio Marcelo , Lavayén Silvina , Hollmann Patricia , Lanfranconi Viviana
Published: January 2020

Escherichia coli productor de toxina Shiga (STEC) es un patógeno emergente a nivel mundial siendo reconocido como agente causal de enfermedades severas en el hombre, como colitis hemorrágica (CH) y síndrome urémico hemolítico (SUH).

El objetivo consistió en determinar el rol de los animales de compañía como potenciales reservorios de STEC en la cadena epidemiológica del SUH.

Se realizó un estudio descriptivo de corte transversal. Entre octubre de 2010 y abril de 2013 se procesaron 162 muestras de perros y gatos realizándose PCR múltiple para la detección de los genes stx1, stx2 y rfbO157, no detectándose señal positiva por PCR en ninguna de las muestras procesadas.

Estos resultados de ausencia de STEC en los animales estudiados podría deberse a que la alimentación de los mismos resultó principalmente con alimentos balanceados ya que el consumo de alimentos contaminados, como por ejemplo carne molida, productos cárnicos crudos o insuficientemente cocidos, constituyen una de las principales fuentes de infección para este microorganismo.
Szczęśliwy książę Jana Dormana jako autoarchiwum
Authors: Rewerenda Magdalena
Published: January 2020

The paper proposes to study the documentation of Jan Dorman’s production based on Oscar Wilde’s Happy Prince as a model for Jan Dorman’s thinking about a connection and a feedback loop between theatre and archive. The production forms the basis for a more detailed examination of Dorman’s multi-layered interest in his own archive as well as the ways in which memories of his art and private life can be preserved. Using the findings developed in the area of archival turn and hauntology, the paper elaborates on the most important spheres of Dorman’s intentional self-archiving: his frantic collecting and cataloguing, the habit of constructing a cultural repository for himself and his co-workers, confabulating and self-mythologising, recycling of objects, characters and motifs to be used again in subsequent productions. In the resulting vision of Dorman’s archive, it appears to be a deliberately constructed performative space rather than merely a collection of material traces of his professional and private life.
CONTROL OF QUANTITY OF WEEDS IN SOWING OF CORN
Authors: Okrushko Svetlana
Published: January 2020

It was established that in the agrophytocenosis of corn on the control variant (without introducing herbicides) a mixed type of debris was formed, in which a group of late spring weeds prevailed.
After the introduction of the soil herbicide Adengo 465 (0.5 l / ha) on the sowing of maize weeds were 92% less compared to the contamination of the control experiment, where the chemical method was not used.
The combination of the use of the soil herbicide Adengo 465 (0.35 l / ha) and the insurance herbicide Master Power (1.25 l / ha in the 4-5 leaf phase of the crop) in the agrophytocenosis of corn provided the qualitative control of the main weed species. At the time of harvesting in corn crops there were 97% less weeds compared with the control variant. The combined use of these herbicides has provided a high increase in the yield of corn grain - 4.8 t / ha.
ANALYSIS OF THE ECOLOGICAL STATE OF FOREST ECOSYSTEMS OF THE EASTERN PODILLIA
Authors: Kravchuk Halyna , Hutsol Alina
Published: January 2020

On the basis of literary sources, the article provides a brief analysis of the ecological state of the forest ecosystems of the Eastern Podillia. Today, one of the main problems of Ukrainian forests is the low level of pollution. There are many environmental factors that reduce forest area, such as forest fires, pests and diseases, natural disasters, illegal logging. Forests dry up, they are ill, often they are uncontrolledly crushed, so today the average rate of pollution in the country - 15.7%, while in order to reach the optimal indicators this percentage should be at level 20. And this means that in the near future it is necessary to plant the young forest about 2 million hectares of Ukrainian lands. In Ukraine, forests are in the zone of industrial pollution, and their general condition does not meet ecological and economic requirements. Particularly relevant forest problems of Ukraine have come about due to the formation of catastrophic floods on the rivers of the Carpathian region, large-scale manifestation of erosion processes, radioactive contamination of the territory, etc. Therefore, in order to increase forest productivity, improve their useful properties and meet the needs of the community in forest resources, reproduction, protection and protection of forests are important. Forests are extremely important. Forests are a national treasure, and in their destination and location, they mainly perform water protection, protection, sanitation, health, recreation, aesthetics, education, other functions, and provide a source for meeting the needs of the community in forest resources.
Methodical aspects of evaluating the cost of crowdfunding capital
Authors: Kuts Lyudmyla
Published: January 2020

Purpose. The purpose of the article is to explore the possibilities of different models of crowdfunding in the formation of equity or loan capital to finance the projects of companies, to develop methodological aspects of the evaluation of the benefits of crowdfunding in comparison with alternative sources of financing.

Methodology of research. General scientific and special methods are used in the research, in particular: analysis and synthesis, theoretical generalization, abstract and logical - in the study of the spectrum of modern sources of capital and their value in financing projects with the implementation of innovative - crowdfunding; the contribution of various crowdfunding models to the formation of equity or debt capital to finance company projects; systematizing the types of costs associated with crowdfunding; economics and mathematics - when developing methods of estimating the cost of crowdfunding capital for different models of crowdfunding.

Findings. Possibilities of different models of crowdfunding in formation of equity or loan capital of companies along with traditional sources of capital are investigated. Methods for estimating the cost of attracting different types of crowdfunding capital are proposed based on a modification of the methods of calculating the cost of relevant traditional sources of capital, which will help more rational use of crowdfunding when financing companies' projects.

Originality. The possibilities of different models of crowdfunding in formation of equity or loan capital for financing of projects of companies are substantiated. The spectrum of costs of companies for crowdfunding is systematized, which serves as a basis for methods of calculating its value as a source of capital. Methods for calculating the cost of crowdfunding capital in terms of its various models are proposed.

Practical value. The findings of the study are aimed at solving the problem of managing the crowdfunding capital of project developers and will facilitate informed making decision in this area. They can be used to manage project funding at different levels.

Key words: crowdfunding; crowdfunding capital; cost of crowdfunding capital; innovation; financing.
Personal income tax: practice and problems of management in local budgets of Ukraine
Authors: Karpyshyn Nataliia , Nipialidi Olha
Published: January 2020

Purpose. The aim of the article is investigation of the practice of tax income on individuals in the local budgets of Ukraine in the context of decentralized reform in order to identify the most pressing problems of collecting PITs and develop a proposal to increase its fiscal role at the local level.

Methodology of research. The following methods are used to achieve this goal: analysis, synthesis and generalization – in the processing of literary, statistical, legislative and Internet sources on the topic of research; methods of systematization and generalization of data, comparison and detail – when conducting analysis of budget indicators; graphical and tabular methods – for visual representation of the processed data; abstract and logical method – to summarize the material presented and formulate conclusions.

Findings. The fiscal role and factors of PIT growth in the local budgets of Ukraine during the period of decentralization reform have been determined. Local governments are found to be underutilizing the potential of PITs to replenish local budgets. The main reserves for the growth of local budget revenues from the PIT are substantiated, namely: solving the problem of illegal employment with the aim of legalizing income for taxation, improving cooperation with the SFSU bodies and improving the efficiency of tax control; improving community asset management; increasing transparency and enhancing community involvement in community governance.

Originality. The main directions of activity of local self-government bodies that will contribute to the gradual increase in the volume of revenues from the personal income tax in the revenues of local budgets of Ukraine are identified.

Practical value. The results of the study can be used in the activities of local governments and local financial authorities in developing a policy of increasing PIT (personal income tax) revenues in local budget revenues.

Key words: personal income tax; local budgets; local budget revenues; local governments.
Innovative activity of SMES as a basis for development of domestic economy
Authors: Tyshchenko Victoria , Krasna Alina
Published: January 2020

Purpose. The aim of the article is conducting a detailed analysis of the impact of ease of doing business in the country (provided by the rating) and the growth of innovation in the country (reflected in the change in the global innovation index) on the change in GDP per capita.

Methodology of research. The theoretical and methodological basis of the research is the works of foreign and domestic scientists in the field of innovative development. The following methods are used in the process of writing the article in order to achieve this goal: theoretical generalization – to highlight common features of innovative activity in Ukraine; statistical analysis – to assess the state of innovation, ease of doing business in Ukraine; cluster analysis – to classify countries based on GII, Ease of Doing Business Index and GDP; correlation analysis – to assess the impact of innovation and ease of doing business on GDP per capita; graphical and tabular – for visual presentation of research results.

Findings. The peculiarities of the state of innovative activity in the country are established. It is argued that the value of the Global Innovation Index (GII) and the ease of doing business (Ease of Doing Business) have a direct impact on GDP per capita. The countries are classified by the values of these indicators and the place of Ukraine is determined.

Originality. There has been a further development of research into the impact of innovative development and ease of doing business on the country's GDP change, in particular, the clustering of these indicators has determined the position of Ukraine in the international arena.

Practical value. The obtained results of the study may be used by future researchers to understand the role of innovation activities of small and medium-sized enterprises in the development of the domestic economy.

Key words: innovation; innovative activity; innovative development; SMEs; global innovation index; ease of doing business index.
Lead Based Metal Organic Frameworks(Pb-MOFs): Anion Influence, Luminescence and Gas Adsorption Study
Authors: Iram Shamaila , Imran Muhammad , Kanwal Farah , Latif Shoomaila , Iqbal Zafar
Published: January 2020

Two Lead based organic frameworks (1&2) have been synthesized using 4,6-dihydroxy-2-mercaptopyrimidine (H2DMP) as organic linker. Lead nitrate (1) and Lead acetate (2) salts were used to investigate their influence on morphology of resulting MOFs, adsorption capacities and luminescence behaviour. Structure and morphology of these MOFs was established on the basis of UV/Vis, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), 1H NMR, energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA) and X-ray diffraction technique. Brunauer-Emmett-Teller (BET) studies revealed better N2 adsorption capacity for 1 (surface area 814 m2/g) when compared with 2 (surface area 196 m2/g). Photoluminescence behaviour of (1&2) was investigated in solid state at room temperature and has been attributed to metal-centred s�p transition.
Surface Water Quality Assessment from a Mining Area. Case study, Groapa Burlacu lake, Targu Ocna, Romania
Authors: Cochiorca Alina , Barsan Narcis , Nedeff Florin Marian , Sandu Ion , Mosnegutu Emilian Florin , Panainte Lehadus Mirela , Chitimus Dana , Irimia Oana , Sandu Ioan Gabriel
Published: January 2020

This paper presents a study on assessment of water quality. According to a study, mining activities have a significant impact on water quality (lakes, surface water and groundwater), which has become a major problem globally. Due to mining and exploitation processes, lakes can be formed around these mines. Also, these lakes have been formed around the world and are steadily increasing. The purpose of this study is to watch the quality of water from the area around mining activities. This study refers to the, Groapa Burlacu lake around the mining exploitation Targu Ocna, Romania. This lake was formed on the northern bottle of the massive salt, strongly affected by the underground activities. Sampling for the determination the concentrations of Cl- and NaCl from the studied area was made at different depths (0 m, -5 m, -10 m, -15 m, -20 m, -25 m, -30 m, -35 m -40 m). Besides these concentrations, physical parameters of the water (pH, turbidity, electrical conductivity, dissolved oxygen and temperature) were also measured. To determine the physical parameters in the monitored area, sampling was done from four different points of the area and then put together for analysis. These parameters were measured on site using portable equipment. The data on the analyzed concentrations indicate that at depths of less than 5.0 m, the NaCl concentration values are more than 250 g/L.
Ultrafiltration Mixed Matrix Membranes Based on Mesoporous Silica (MCM-41, HMS)Embedded in Polysulfone
Authors: Razvan Anca , Popa Daniela F. , Oprea Ovidiu , Vasile Eugeniu , Dumitru Florina , Nechifor Gheorghe
Published: January 2020

Three composite membranes (M1-M3), with mesoporous silica (MCM-41 or HMS-C12/C16-type) embedded in polysulfone (Psf) were obtained by phase-inversion method and their performances were tested for use in ultrafiltration membrane processes. The structures of M (Psf 12%, reference membrane), M1 (Psf 12% + MCM-41), M2 (Psf 12% + HMS-C12), M3 (Psf 12% + HMS-C16) have been assessed by FTIR, TG-DSC and SEM-EDAX and the morphology and their hydrodynamic performances have been evaluated by contact angle measurements, dead-end and cross-flow filtration experiments.
Anti-HIV / HCV Activity of Cyanobacterial Phycobiliproteins by a New Standardized Method Using Bacteriophage Surrogates
Authors: Hamid Mohammad I. Abd El , Fatah Walaa M. Abd El , Morsi Adel A. El , Draz Mohamed Shehata , Kallakuri Shantanu , Bungau Simona , Endres Laura , Bardaca (Urducea) Cristina , Hafez Elsayed E.
Published: January 2020

The control of the viral infections requires efficient, rapid and safe testing procedures. We tested the efficiency of a quick and reliable alternative assay to the standard plaque assay (PA) in the detection of viral inhibition. Using MS-2 and FX-174 phages, the developed assay was used to evaluate the potential of cyanobacterial phycobiliproteins (PBS) as natural antiviral bioactive molecules against HIV and HCV. The antiviral activity was examined by mixing the phage with crude aqueous extracts in a 1:1 (v/v) ratio for 1hr at 4oC. The viral titer of MS-2 and FX-174 was reduced by 0.92 LR and 1.19 LR, respectively. In the case of the crude PBS extract of Spirulina platensis, similar result trends were obtained by virion titration which indicated that a strong correlation between the two assays was verified (�90 %). The morphological characteristics of both phages were severely affected when treated with the extract, whereas the characteristic features of their hosts seem unaffected. The PBS was found to affect the adsorption of the phages on their bacterial hosts and consequently viral reproduction. In conclusion, MS-2 and FX-174 can be used in drug evaluation by the well standardized method developed in this study.
Evaluation and Prevention of Changes in Oral Cavity Through Cytotoxic Effect of the Chemical Components from Dental Materials
Authors: Armencia Adina Oana , Saveanu Catalina Iulia , Hurjui Loredana Liliana , Cherci Adrian Dorin , Balcos Carina , Voinea Georgescu Ruxandra Nicolette , Tarniceriu Cristina Claudia , Anistoroaei Daniela
Published: January 2020

The use of a suitable biological material, represented by the normal cell culture cell line RM, consisting of monkey kidney cells or of suitable experimental models allow the investigation of the reactivity of the cell protein synthesis process (illustrated by the total protein content of the cell cultures aged 72 hours, after a 48-hour treatment), cell proliferation (expressed by the evolution of the total cell number during cell culture development), cell viability (characterized by the dynamics of the dead / living cells ratio), cell apoptosis and cell culture development. Alteration of these processes reflects the cytotoxic impact of some products on protein synthesis, mitosis, cell apoptosis and cell viability.
A New, Rapid and Efficient HPLC Method to Assay Resveratrol in Food Supplements
Authors: Craciun Veronica Isabela , Gligor Felicia Gabriela , Juncan Anca Maria , Chis Adriana Aurelia , Rus Luca Liviu
Published: January 2020

The aim of this study consisted in the development of a rapid and reliable high performance liquid chromatography (HPLC) method for resveratrol identification and assay in food supplements, trying to offer a robust, direct and convenient solution. By this method, several supplements with varying resveratrol content, between 103 and 119% of the stated amount per dosage form, were analyzed.
Steven-Johnson Syndrome in Child
Authors: Nedelcuta Ramona Mihaela , Baleanu Vlad Dumitru , Davitoiu Dragos Virgil , Tenea Cojan Tiberiu Stefanita , Ciora Cosmin Alexandru , Calin Gigi
Published: January 2020

Steven-Johnson Syndrome and NET (toxic epidermal necrolysis), different expressions of the same condition were named according to the percentage of affected skin: [10% in Steven-Johnson Syndrome and]30% in NET. Small ages may be a target for these rare diseases, in direct relation to drug abuse (antibiotics, NSAIDs, antiepileptics, etc.). Survival depends on the rapid response of the causative agent, the early investigation of the therapy to block Fas-FasL interaction and to reestablish skin integrity (Fas-receptor on the surface of cells involved in apoptosis). Massive skin damage is associated with a severe prognosis, as is the age of the baby.It is necessary to use wise the medication or automedication for a complete and effective prevention of Steven-Johnson Syndrome.
Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma
Authors: Farcas Claudia Geanina , Moaca Elena Alina , Dragoi Razvan , Berceanu Vaduva Delia , Marcovici Iasmina , Mihali Ciprian Valentin , Loghin Felicia
Published: January 2020

Magnetoliposomes were placed into the biomedical spotlight due to their unique structure, preserving also magnetic features valuable for biomedical applications. The present study provides a preliminary evidence of the cytotoxicity induced by betulinic acid-loaded magnetoliposomes (BA-Fe3O4@Lip) on two melanoma cell lines - A375 and B164A5 cells and one healthy cell line - mice epidermis JB6 Cl 41-5a cells, augmented by references to potential biomedical applications. BA-Fe3O4@Lip showed significant cytotoxicity on the melanoma cell lines, compared with the blank liposomal structures. In addition, the healthy cell line displayed good viability rate after exposure to BA-Fe3O4@Lip.
Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome
Authors: Hritcu Luminita Diana , Padurariu Manuela , Ciobica Alin , Horhogea Cristina , Spataru Mihaela Claudia , Spataru Constantin , Burtan Liviu , Stefanescu Cristinel
Published: January 2020

The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.
PENGARUH KONFLIK KERJA DAN STRES KERJA TERHADAP KINERJA KARYAWAN
Authors: Susilo Yohanes , Wahyudin Wahyudin
Published: January 2020

Dai Sabisu Indonesia as a whole has good employee performance. The company must pay attention and fix work conflicts and work stress at PT.DSI. Therefore researchers aim to determine the effect of a work conflict and work stress on employee performance partially or simultaneously.

Problem formulation: How partial influence Work Conflict on Employee Performance at PT. Indonesian Social Sciences, How Partly Influences Work Stress on Employee Performance at PT. Dai Sabisu Indonesia and how simultaneous influence Work Conflict and Work Stress on Employee Performance at PT. DSi

The population is employees at PT. DSI, the method of using sampling is using the Non-Probability technique. Methods of data collection: Questionnaires, Interviews, Literature studies, data analysis methods: Data Quality Test, Classical Assumption Test, Hypothesis Test.

The results of the study: Work conflict has a significant effect on employee performance, and work stress has a significant effect on Conflict and Job Stress simultaneously has a significant effect on Employee Performance.

 

Abstrak

Dai Sabisu Indonesia keseluruhan karyawan baik kinerjanya.Perusahaan harus memperhatikan dan memperbaiki konflik kerja dan stres kerja di PT.DSI. Karenanya peneliti bertujuan mengetahui pengaruh konflik kerja dan stres kerja terhadap kinerja karyawan secara parsial maupun simultan.

Rumusan masalah: Seberapa pengaruh secara parsial Konflik Kerja terhadap Kinerja Karyawan di PT. Dai Sabisu Indonesia?, Seberapa pengaruh secara parsial Stres Kerja terhadap Kinerja Karyawan di PT. Dai Sabisu Indonesia? dan seberapa pengaruh secara simultan Konflik Kerja dan Stres Kerja terhadap Kinerja Karyawan  pada PT. DSI?

Populasinya adalah karyawan pada PT. DSI, metode menggunakan sampling yaitu menggunakan teknik Non Probability. Metode pengumpulan data: Kuesioner, Wawancara, Studi pustaka, metode analisis data: Uji Kualitas Data,  Uji Asumsi Klasik,Uji Hipotesis.

Hasil penelitian: Konflik kerrja berpengaruh signifikan terhadap Kinerja karyawan, dan Stress kerja berpengaruh signifikan terhadap Konflik dan Stres Kerja  secara simultan berpengaruh signifikan terhadap Kinerja Karyawan.
Characterizing Magnetic Reconnection Regions Using Gaussian Mixture Models on Particle Velocity Distributions
Authors: Dupuis Romain , Goldman Martin V. , Newman David L. , Amaya Jorge , Lapenta Giovanni
Published: January 2020

We present a method based on unsupervised machine learning to identify and characterize regions of interest using particle velocity distributions as a signature pattern. An automatic density estimation technique is applied to particle distributions provided by particle-in-cell simulations to study magnetic reconnection regions. Its application to magnetic reconnection is new. The key components of the method involve (i) a Gaussian mixture model determining the presence of a given number of subpopulations within an overall population, and (ii) a model selection technique with a Bayesian information criterion to estimate the appropriate number of subpopulations. Thus, this method automatically identifies the presence of complex distributions, such as beams or other non-Maxwellian features, and can be used as a detection algorithm able to identify reconnection regions. The approach is demonstrated for a specific double Harris sheet simulation, but it can in principle be applied to any other type of simulation data on the particle distribution function.
The Activation of Galactic Nuclei and Their Accretion Rates Are Linked to the Star Formation Rates and Bulge-types of Their Host Galaxies
Authors: Yesuf Hassen M. , Faber S. M. , Koo David C. , Woo Joanna , Primack Joel R. , Luo Yifei
Published: January 2020

We use bulge-type classifications of 809 representative Sloan Digital Sky Survey galaxies by Gadotti to classify a large sample of galaxies into real bulges (classical or elliptical) and pseudobulges using Random Forest. We use structural and stellar population predictors that can easily be measured without image decomposition. Multiple parameters—such as the central-mass density with 1 kpc, concentration index, Sérsic index, and velocity dispersion—result in accurate bulge classifications when combined together. We classify ∼44,500 face-on galaxies above stellar mass of 1010
M
⊙ and redshift 0.02 < z < 0.07 into real bulges or pseudobulges with 93% ± 2% accuracy. We show that ∼75%–90% of active galactic nuclei (AGNs) identified by the optical line ratio diagnostic are hosted by real bulges. The pseudobulge fraction significantly decreases with AGN signature as the line ratios change from indicating pure star formation (∼54% ± 4%), to composite of star formation and AGN (∼18% ± 3%), and to AGN-dominated galaxies (∼5% ± 3%). Using the dust-corrected [O iii] luminosity as an AGN accretion indicator, and the stellar mass and radius as proxies for a black hole mass, we find that AGNs in real bulges have lower Eddington ratios than AGNs in pseudobulges. Real bulges have a wide range of AGN and star formation activities, although most of them are weak AGNs. For both bulge-types, their Eddington ratios are correlated with specific star formation rates (SSFR). Real bulges have a lower specific accretion rate but higher AGN fraction than pseudobulges do at similar SSFRs.
The Swedish Malaise Trap Project: A 15 Year Retrospective on a Countrywide Insect Inventory
Authors: Karlsson Dave , Hartop Emily , Forshage Mattias , Jaschhof Mathias , Ronquist Fredrik
Published: January 2020

The Swedish Malaise Trap Project (SMTP) is one of the most ambitious insect inventories ever attempted. The project was designed to target poorly known insect groups across a diverse range of habitats in Sweden. The field campaign involved the deployment of 73 Malaise traps at 55 localities across the country for three years (2003-2006). Over the past 15 years, the collected material has been hand sorted by trained technicians into over 300 taxonomic fractions suitable for expert attention. The resulting collection is a tremendous asset for entomologists around the world, especially as we now face a desperate need for baseline data to evaluate phenomena like insect decline and climate change. Here, we describe the history, organisation, methodology and logistics of the SMTP, focusing on the rationale for the decisions taken and the lessons learned along the way. The SMTP represents one of the early instances of community science applied to large-scale inventory work, with a heavy reliance on volunteers in both the field and the laboratory. We give estimates of both staff effort and volunteer effort involved. The project has been funded by the Swedish Taxonomy Initiative; in total, the inventory has cost less than 30 million SEK (approximately 3.1 million USD). Based on a subset of the samples, we characterise the size and taxonomic composition of the SMTP material. Several different extrapolation methods suggest that the material comprises around 20 million specimens in total. The material is dominated by Diptera (75% of the specimens) and Hymenoptera (15% of specimens). Amongst the Diptera, the dominant groups are Chironomidae (37% of specimens), Sciaridae (15%), Phoridae (13%), Cecidomyiidae (9.5%) and Mycetophilidae (9.4%). Within Hymenoptera, the major groups are Ichneumonidae (44% of specimens), Diaprioidea (19%), Braconidae (9.6%), Platygastroidea (8.5%) and Chalcidoidea (7.9%). The taxonomic composition varies with latitude and season. Several Diptera and Hymenoptera groups are more common in non-summer samples (collected from September to April) and in the North, while others show the opposite pattern. About 1% of the total material has been processed and identified by experts so far. This material represents over 4,000 species. One third of these had not been recorded from Sweden before and almost 700 of them are new to science. These results reveal the large amounts of taxonomic work still needed on Palaearctic insect faunas. Based on the SMTP experiences, we discuss aspects of planning and conducting future large-scale insect inventory projects using mainly traditional approaches in relation to more recent approaches that rely on molecular techniques.
Art(bio)éthique : vers de nouvelles relations entre le bioart et la bioéthique
Authors: Couture Vincent , Noury Mathieu
Published: January 2020

Inspirés par les avancées scientifiques les plus récentes dans le domaine de la biologie et des biotechnologies, des artistes proposent, depuis un certain nombre d’années déjà, des créations artistiques singulières à la frontière de l’art et de la science qui élèvent ces avancées et leurs objets, le vivant sous ses différentes formes, au rang de propositions esthétiques. Ces nouvelles pratiques artistiques se développent sous le nom de « bioart » et ont pour effet de considérablement questionner la frontière entre l’art et la science. Les artistes investissent les laboratoires et manipulent le vivant. Plusieurs scientifiques s’aventurent eux-mêmes dans ces nouveaux territoires ou collaborent à des créations. Ce nouveau champ d’investigation artistique inspire ainsi un certain nombre de réflexions à la bioéthique. Intitulé « Art(bio)éthique », ce numéro spécial propose une rencontre entre le bioart et la bioéthique afin d’offrir un échantillon récent et varié de réflexions sur les relations qui se tissent entre ces deux disciplines.
Chapitre 3. Horizontal Exchange, Relations, and Resistance in Bioart and Practice-based Research
Authors: Hey Maya , Hunter WhiteFeather , St-Hilaire Emilie
Published: January 2020

Le bioart existe à l’intersection de deux champs de connaissances et de production spécialisés et élite : la biotechnologie et l’art. Ces deux spécialisations occupent des strata différent dans la hiérarchie académique, nécessitant des qualifications et des rigueurs disciplinaires qui, historiquement valorisent leurs spécificités et non leurs similarités en recherche. Une expertise certifiée est privilégiée au prix de d’autres formes de connaissances. Avec son chevauchement des arts et des sciences, comment le bioart peux-t-il fonctionner pour aplanir la hiérarchie existante et mener à des méthodes collaboratives plus horizontales, menant à une compréhension plus critique du bioart ? Cet article suit l’idée de la collaboration horizontale théorisé par Couture et al. (2017), tout en attendant aux ruptures et aux résistances (réels, perçus, ou construites) qui existes lorsqu’on travail transversalement dans une institution verticale. Combinant des interventions théoriques avec des études de cas qui déconstruisent des espaces d’enquêtes bioartistiques – du labo au studio, dans la cuisine, la salle de classe, ou dans la galerie – ce papier vise à créé des « bonnes » relations selon la définition de Joanna Zylinska, notamment comment un corps récompose sa relation à l’autre, haussant ainsi le pouvoir de tout les deux.
De l’autre côté du miroir : l’éducation artistique aux États-Unis
Authors: Montoya Nathalie
Published: January 2020

Peu comparables à l’éducation artistique et culturelle à la française, l’ art education et les formes de pédagogie mises en œuvre aux États-Unis insistent sur la valorisation des élèves et l’affirmation individuelle de chacun, comme si, au fond, le développement des aptitudes des élèves primait toujours sur la dévotion due à l’institution et à l’art. À une ambition de démocratisation de la culture par la fréquentation des œuvres et des artistes, les projets américains opposeraient un objectif de transformation des individus par la participation culturelle. L’article s’appuie sur une enquête menée sur des teen programs proposés à des lycéens par de grands musées américains, notamment le MoMA de New York. Là où les projets français déploient une conception charismatique de l’artiste, ces programmes mobilisent des teaching artists recrutés pour leur sens de la pédagogie davantage que pour la qualité ou l’originalité de leurs créations.
Co-construire des contenus en Éducation Physique et Sportive, Oui mais comment ? Illustration en athlétisme en classe de Terminale
Authors: Le Paven Maël , Musard Mathilde
Published: January 2020

Cette étude montre comment les régulations didactiques d’élèves de Terminale se construisent dans l’action conjointe en lien avec celles de leur professeur, lors de leçons de lancer de disque organisées sous forme d’ateliers de travail en autonomie. Les contenus sélectionnés par le professeur ainsi que leur mode de mise en scène déterminent ceux choisis par les élèves et leurs régulations, privant parfois ces derniers de l’accès à certains contenus essentiels à la construction d’un geste efficace. Former les enseignants et les élèves à interagir pour favoriser la co-construction des contenus s’avère donc indispensable.
Les textes de savoirs dans les cahiers de SVT des élèves de 6 e . Problématisation et inégalités
Authors: Van Brederode Marion
Published: January 2020

Cet article vise à éclairer les processus qui interviennent dans la production des inégalités d’apprentissage en sciences de la vie et de la terre. En s’appuyant sur les travaux de la didactique qui postulent que les savoirs scientifiques en classe doivent être fondés en raison, le degré de problématisation des textes de savoirs disponibles dans les cahiers des élèves a été analysé. L’analyse qualitative fait apparaître des variations qui pourraient conduire à une saisie différentielle des raisons qui fondent les savoirs travaillés. L’analyse quantitative montre que dans des établissements socialement contrastés, les élèves n’ont pas accès à des savoirs ayant le même degré de problématisation.
Comparison of Results of Medial Rectus Muscle Recession Using Augmentation, Faden Procedure, and Slanted Recession in the Treatment of High Accommodative Convergence/Accommodation Ratio Esotropia
Authors: Gharabaghi Davoud , Zanjani Leila Kazemi
Published: January 2020

Abstract

Background and Purpose: According to the literature, accommodative esotropia has an unpredictable course when nonsurgical treatment is considered, especially in cases with a high accommodative convergence/accommodation ratio (AQA). The aim of this study was to compare the results of augmented recession, slanted recession, and recession with posterior fixation suture of the medial rectus muscles in the treatment of high AQA esotropia.

Subjects and Methods: Twenty-eight children (4 to 14 years old) with high AQA esotropia with a near-distance disparity greater than 10 PD were included in a prospective, randomized, blinded clinical trial. Nine children underwent recession of both medial rectus muscles and posterior fixation suture (Faden procedure), 9 children underwent augmented recession of the medial rectus muscles, and 10 children underwent slanted recession of both medial rectus muscles. The amount of esodeviation was measured before strabismus surgery and at least 6 months postoperatively.

Resuite: In the augmented recession group, the mean near-distance disparity was reduced from 16.33 ± 2.1 7 PD preoperatively to 7.55 ± 3.87 PD postoperatively (54.21%; P = .056). In the Faden procedure group, it was reduced from 1 5.22 ± 4.08 PD to 2.55 ± 4.03 PD (80.7%; P = .056). In the slanted recession group, it was reduced from 15.50 ± 4.30 PD to 4.1 0 ± 4.80 PD (67.55%; P = .056).

Conclusions: The Faden procedure had the best outcome, but slanted recession also was successful. Because of our good results and an easy, noninvasive approach without any additional complications, we recommend slanted recession to treat high AQA esotropia.

J Pediatr Ophthalmol Strabismus 2006;43:91-94.
Unilateral Clinical Anophthalmia With Optic Nerve Hypoplasia in the Fellow Eye
Authors: Ceyhan Dogan , See Robert F , Schnall Bruce M
Published: January 2020

Abstract. We present the clinical and radiologic findings of two cases of clinical anophthalmia in one eye and optic nerve hypoplasia in the other eye. We propose possible causes of this rare finding. J Pediatr Ophthalmol Strabismus 2006;43:1 16-1 18.