bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanistic evaluation of virus clearance by depth filtration
Authors: Venkiteshwaran Adith , Fogle Jace , Patnaik Purbasa , Kowle Ron , Chen Dayue
Published: February 2015

Virus clearance by depth filtration has not been well‐understood mechanistically due to lack of quantitative data on filter charge characteristics and absence of systematic studies. It is generally believed that both electrostatic interactions and sized based mechanical entrapment contribute to virus clearance by depth filtration. In order to establish whether the effectiveness of virus clearance correlates with the charge characteristics of a given depth filter, a counter‐ion displacement technique was employed to determine the ionic capacity for several depth filters. Two depth filters (Millipore B1HC and X0HC) with significant differences in ionic capacities were selected and evaluated for their ability to eliminate viruses. The high ionic capacity X0HC filter showed complete porcine parvovirus (PPV) clearance (eliminating the spiked viruses to below the limit of detection) under low conductivity conditions (≤2.5 mS/cm), achieving a log10 reduction factor (LRF) of > 4.8. On the other hand, the low ionic capacity B1HC filter achieved only ∼2.1–3.0 LRF of PPV clearance under the same conditions. These results indicate that parvovirus clearance by these two depth filters are mainly achieved via electrostatic interactions between the filters and PPV. When much larger xenotropic murine leukemia virus (XMuLV) was used as the model virus, complete retrovirus clearance was obtained under all conditions evaluated for both depth filters, suggesting the involvement of mechanisms other than just electrostatic interactions in XMuLV clearance. © 2014 American Institute of Chemical Engineers Biotechnol. Prog., 31:431–437, 2015
Induction therapy with cetuximab plus docetaxel, cisplatin, and 5‐fluorouracil (ETPF) in patients with resectable nonmetastatic stage III or IV squamous cell carcinoma of the oropharynx. A GERCOR phase II ECHO‐07 study
Authors: Chibaudel Benoist , Lacave Roger , Lefevre Marine , Soussan Patrick , Antoine Martine , Périé Sophie , Belloc Jean‐Baptiste , Banal Alain , Albert Sébastien , Chabolle Frédéric , Céruse Philippe , Baril Philippe , Gatineau Michel , Housset Martin , Moukoko Rachel , Benetkiewicz Magdalena , de Gramont Aimery , Bonnetain Franck , Lacau St Guily Jean
Published: February 2015

Induction TPF regimen is a standard treatment option for squamous cell carcinoma (SCC) of the oropharynx. The efficacy and safety of adding cetuximab to induction TPF (ETPF) therapy was evaluated. Patients with nonmetastatic resectable stage III/IV SCC of the oropharynx were treated with weekly cetuximab followed the same day by docetaxel and cisplatin and by a continuous infusion of 5‐fluorouracil on days 1‐5 (every 3 weeks, 3 cycles). The primary endpoint was clinical and radiological complete response (crCR) of primary tumor at 3 months. Secondary endpoints were crCR rates, overall response, pathological CR, progression‐free survival, overall survival, and safety. Forty‐two patients were enrolled, and 41 received ETPF. The all nine planned cetuximab doses and the full three doses of planned chemotherapy were completed in 31 (76%) and 36 (88%) patients, respectively. Twelve (29%) patients required dose reduction. The crCR of primary tumor at the completion of therapy was observed in nine (22%) patients. ETPF was associated with a tumor objective response rate (ORR) of 58%. The most frequent grade 3–4 toxicities were as follows: nonfebrile neutropenia (39%), febrile neutropenia (19%), diarrhea (10%), and stomatitis (12%). Eighteen (44%) patients experienced acne‐like skin reactions of any grade. One toxic death occurred secondary to chemotherapy‐induced colitis with colonic perforation. This phase II study reports an interesting response rate for ETPF in patients with moderately advanced SCC of the oropharynx. The schedule of ETPF evaluated in this study cannot be recommended at this dosage.
Alternative Reagents for Methotrexate as Immobilizing Anchor Moieties in the Optimization of MASPIT: Synthesis and Biological Evaluation
Authors: De Clercq Dries J. H. , Risseeuw Martijn D. P. , Karalic Izet , De Smet Anne‐Sophie , Defever Dieter , Tavernier Jan , Lievens Sam , Van Calenbergh Serge
Published: February 2015

We report the evaluation of two alternative chemical dimerizer approaches aimed at increasing the sensitivity of MASPIT, a three‐hybrid system that enables small‐molecule target protein profiling in intact human cells. To circumvent the potential limitations related to the binding of methotrexate (MTX) to endogenous human dihydrofolate reductase (DHFR), we explored trimethoprim (TMP) as an alternative prokaryote‐specific DHFR ligand. MASPIT evaluation of TMP fusion compounds with tamoxifen, reversine, and simvastatin as model baits, resulted in dose–response curves shifted towards lower EC50 values than those of their MTX congeners. Furthermore, a scalable azido‐TMP reagent was synthesized that displayed a similar improvement in sensitivity, possibly owing to increased membrane permeability relative to the MTX anchor. Applying the SNAP‐tag approach to introduce a covalent bond into the system, on the other hand, produced an inferior readout than in the MTX‐ or TMP‐tag based assay.
Pyrochlore and Perovskite Potassium Tantalate: Enthalpies of Formation and Phase Transformation
Authors: Zlotnik Sebastian , Sahu Sulata K. , Navrotsky Alexandra , Vilarinho Paula M.
Published: February 2015

Alkali niobates and tantalates are currently important lead‐free functional oxides. The formation and decomposition energetics of potassium tantalum oxide compounds (K2OTa2O5) were measured by high‐temperature oxide melt solution calorimetry. The enthalpies of formation from oxides of KTaO3 perovskite and defect pyrochlores with K/Ta ratio of less than 1 stoichiometry—K0.873Ta2.226O6, K1.128Ta2.175O6, and K1.291Ta2.142O6—were experimentally determined, and the values are (−203.63±2.92) kJ mol−1 for KTaO3 perovskite, and (−339.54±5.03) kJ mol−1, (−369.71±4.84) kJ mol−1, and (−364.78±4.24) kJ mol−1, respectively, for non‐stoichiometric pyrochlores. That of stoichiometric defect K2Ta2O6 pyrochlore, by extrapolation, is (−409.87±6.89) kJ mol−1. Thus, the enthalpy of the stoichiometric pyrochlore and perovskite at K/Ta=1 stoichiometry are equal in energy within experimental error. By providing data on the thermodynamic stability of each phase, this work supplies knowledge on the phase‐formation process and phase stability within the K2OTa2O5 system, thus assisting in the synthesis of materials with reproducible properties based on controlled processing. Additionally, the relation of stoichiometric and non‐stoichiometric pyrochlore with perovskite structure in potassium tantalum oxide system is discussed.
Chiral Perylene Diimides: Building Blocks for Ionic Self‐Assembly
Authors: Echue Geraldine , Lloyd‐Jones Guy C. , Faul Charl F. J.
Published: February 2015

A chiral perylene diimide building block has been prepared based on an amine derivative of the amino acid L‐phenylalanine. Detailed studies were carried out into the self‐assembly behaviour of the material in solution and the solid state using UV/Vis, circular dichroism (CD) and fluorescence spectroscopy. For the charged building block BTPPP, the molecular chirality of the side chains is translated into the chiral supramolecular structure in the form of right‐handed helical aggregates in aqueous solution. Temperature‐dependent UV/Vis studies of BTPPP in aqueous solution showed that the self‐assembly behaviour of this dye can be well described by an isodesmic model in which aggregation occurs to generate short stacks in a reversible manner. Wide‐angle X‐ray diffraction studies (WXRD) revealed that this material self‐organises into aggregates with π–π stacking distances typical for π‐conjugated materials. TEM investigations revealed the formation of self‐assembled structures of low order and with no expression of chirality evident. Differential scanning calorimetry (DSC) and polarised optical microscopy (POM) were used to investigate the mesophase properties. Optical textures representative of columnar liquid–crystalline phases were observed for solvent‐annealed samples of BTPPP. The high solubility, tunable self‐assembly and chiral ordering of these materials demonstrate their potential as new molecular building blocks for use in the construction of chiro‐optical structures and devices.
Selective Ruthenium Labeling of the Tryptophan Residue in the Bee Venom Peptide Melittin
Authors: Perekalin Dmitry S. , Novikov Valentin V. , Pavlov Alexander A. , Ivanov Igor A. , Anisimova Natalia Yu. , Kopylov Alexey N. , Volkov Dmitry S. , Seregina Irina F. , Bolshov Michail A. , Kudinov Alexander R.
Published: February 2015

Melittin is a membrane‐active peptide from bee venom with promising antimicrobial and anticancer activity. Herein we report on a simple and selective method for labeling of the tryptophan residue in melittin by the organometallic fragment [(C5H5)Ru]+ in aqueous solution and in air. Ruthenium coordination does not disturb the secondary structure of the peptide (as verified by 2D NMR spectroscopy), but changes the pattern of its intermolecular interactions resulting in an 11‐fold decrease of hemolytic activity. The high stability of the organometallic conjugate allowed the establishment of the biodistribution of the labeled melittin in mice by inductively coupled plasma MS analysis of ruthenium.
Calcium‐Catalyzed Formal [2+2+2] Cycloaddition
Authors: Meyer Vera J. , Ascheberg Christoph , Niggemann Meike
Published: February 2015

A formal intermolecular [2+2+2] cycloaddition reaction of enynes to aldehydes is presented, which can be realized in the presence of a simple and benign calcium catalyst. The reaction proceeds with excellent chemo, regio‐ and diastereoselectivity and leads to a one‐step assembly of highly interesting bicyclic building blocks containing up to three stereocenters from simple precursors via a new type of skeletal rearrangement of enynes. The observed diastereoselectivity is accounted for by two different mechanistic proposals. The first one engages mechanistic prospects arising from a gold catalyzed reaction in the absence of the stabilizing gold substituent. The second proposal involves an unprecedented cyclization–carbonyl allene ene reaction–hydroalkoxylation cascade.
ChemInform Abstract: The 3R Polymorph of CaSi2.
Authors: Nedumkandathil Reji , Benson Daryn E. , Grins Jekabs , Spektor Kristina , Haeussermann Ulrich
Published: February 2015

CaSi2 is prepared by arc melting the elements in the ratio Ca:Si = 1:2.02.
ChemInform Abstract: Magnetic Order and Crystal Structure Study of YNi4Si‐Type NdNi4Si.
Authors: Yao Jinlei , Isnard O. , Morozkin A. V. , Ivanova T. I. , Koshkido'ko Yu. S. , Bogdanov A. E. , Nikitin S. A. , Suski W.
Published: February 2015

NdNi4Si is prepared by arc melting of stoichiometric amounts of the elements followed by annealing under Ar (quartz tube, 1070 K, 200 h).
ChemInform Abstract: Synthesis, Crystal Structure and Ion Mobility in the Complex Fluorides of Antimony (III) with the Lithium Cation.
Authors: Makarenko N. V. , Udovenko A. A. , Zemnukhova L. A. , Kavun V. Ya. , Polyantsev M. M.
Published: February 2015

Compounds (III) and (IV) are characterized by single crystal XRD, IR, 7Li, and 19F NMR spectroscopy.
ChemInform Abstract: Ba2TeO: A New Layered Oxytelluride.
Authors: Besara T. , Ramirez D. , Sun J. , Whalen J. B. , Tokumoto T. D. , McGill S. A. , Singh D. J. , Siegrist T.
Published: February 2015

Single crystals of the semiconducting Ba2TeO are prepared from BaO and Te in a molten Ba flux in the molar ratio of 1:1:20 (steel crucible in evacuated quartz tube, 1000 °C, 20 h; cooling to 820 °C within 50 h).
ChemInform Abstract: Bismuth Zinc Vanadate, BiZn2VO6: New Crystal Structure Type and Electronic Structure.
Authors: Eliziario Nunes Sayonara , Wang Chun‐Hai , So Karwei , Evans John S. O. , Radosavljevic Evans Ivana
Published: February 2015

BiZn2VO6 is prepared by firing stoichiometric amounts of Bi2O3, ZnO, CuO, and NH4VO3 (Al2O3 crucible, 1.
ChemInform Abstract: Ca2Cr0.5Ga1.5O5 — An Extremely Redox‐Stable Brownmillerite Phase.
Authors: Luo Kun , Amano Patino Midori , Hayward Michael A.
Published: February 2015

Samples of Ca2CrxGa2‐xO5 are prepared by solid state reaction of stoichiometric amounts of CaCO3, Ga2O3, and Cr2O3 under Ar (1.
ChemInform Abstract: Controlling the Ring Curvature, Solution Assembly, and Reactivity of Gigantic Molybdenum Blue Wheels.
Authors: Xuan Weimin , Surman Andrew J. , Miras Haralampos N. , Long De‐Liang , Cronin Leroy
Published: February 2015

Compounds (III) and (IV) are synthesized by reduction of an acidified suspension of cerium polymolybdate in water and characterized by single crystal XRD, IR and Raman spectroscopy, and electrospray‐ionization ion‐mobility mass spectrometry.
ChemInform Abstract: Synthesis, Structure and Properties of Layered Iron‐Oxychalcogenides Nd2Fe2Se2‐xSxO3.
Authors: Liu Y. , Zhang S. B. , Tan S. G. , Yuan B. , Kan X. C. , Zu L. , Sun Y. P.
Published: February 2015

The new series of title compounds (x = 0, 0.1, 0.2, 0.3, 0.4) is synthesized by solid state reaction of stoichiometric mixtures of Nd2O3, Fe, Se, and S powders (evacuated quartz tubes, 1273 K, 48 h).
ChemInform Abstract: Four High‐Temperature Ferromagnets in the Hf—Fe—Sn System.
Authors: Calta Nicholas P. , Francisco Melanie C. , Malliakas Christos D. , Schlueter John A. , Kanatzidis Mercouri G.
Published: February 2015

Hf1.823Fe5Sn3.815 (I), HfFe2‐xSnx (II), and two polymorphs of Hf1‐xFe2Snx (III), all closely related to HfFe2 Laves phase parent structures are prepared by melting the elements using excess Sn as a flux (Al crucible in evacuated silica tube, 1100 °C within 17 h; cooling to 600 (I) and 850 °C (II) and (III) within 50 h for Sn removal by centrifugation) prior to HCl etching of residual Sn and magnetic separation.
ChemInform Abstract: Synthesis, Crystal Structure and Electrical Proprieties of New Phosphate KCoP3O9.
Authors: Ben Smida Y. , Guesmi A. , Georges S. , Zid M. F.
Published: February 2015

Crystals of the new title compound are prepared by solid state reaction of K2CO3, Co(OAc)2·4H2O, and NH4H2PO4 in the molar ratio of K:Co:P = 1:1:3 (porcelain crucible, 300 °C in air for 12 h and 820 °C for 3 d).
ChemInform Abstract: A Cesium Copper Vanadyl‐Diphosphate: Synthesis, Crystal Structure and Physical Properties.
Authors: Shvanskaya Larisa , Yakubovich Olga , Bychkov Andrey , Shcherbakov Vasiliy , Golovanov Alexey , Zvereva Elena , Volkova Olga , Vasiliev Alexander
Published: February 2015

Non‐centrosymmetric orthorhombic single crystals of Cs2Cu1.1(VO)1.9 (P2O7)2 are obtained by spontaneous crystallization from a melt containing CsH2PO4, CuO, and V2O5 in the molar ratio of 2:2:1 (Al2O3 crucible, 850 °C, 72 h).
ChemInform Abstract: Asymmetric Hydroxylative Phenol Dearomatization Promoted by Chiral Binaphthylic and Biphenylic Iodanes.
Authors: Bosset Cyril , Coffinier Romain , Peixoto Philippe A. , El Assal Mourad , Miqueu Karinne , Sotiropoulos Jean‐Marc , Pouysegu Laurent , Quideau Stephane
Published: February 2015

A series of chiral biaryl iodanes is prepared and the asymmetric hydroxylative dearomatization of 2‐methylnaphthol is investigated to reveal BDJ as optimal reagent.
ChemInform Abstract: Carboxylic Acids as a Traceless Activation Group for Conjugate Additions: A Three‐Step Synthesis of (.+‐.)‐Pregabalin (XXV).
Authors: Chu Lingling , Ohta Chisa , Zuo Zhiwei , MacMillan David W. C.
Published: February 2015

A photon‐induced addition is developed which can be applied to a broad spectrum of carboxylic acids including natural and unnatural amino acids.
ChemInform Abstract: Stereoselective Synthesis of Enantiopure Oxetanes, a Carbohydrate Mimic, an ε‐Lactone, and Cyclitols from Biocatalytically Derived β‐Hydroxy Esters as Chiral Precursors.
Authors: Das Debabrata , Halder Joydev , Bhuniya Rajib , Nanda Samik
Published: February 2015

Enantiopure α‐substituted β‐hydroxy esters, which are obtained by biocatalytic reduction with Klebsiella pneumoniae, serve as chirons for preparation of oxetanes (II), carbohydrate mimic (V), ε‐lactone (VII) and cyclitols (X), (XI), and (XV).
ChemInform Abstract: Reaction of Enamines and Azaenamines Containing a Thioamide Group with Dimethyl Acetylenedicarboxylate
Authors: Belskaya N. P. , Lugovik K. I. , Ivina A. D. , Bakulev V. A. , Fan Z. J.
Published: February 2015

as a method for the synthesis of functionalized thiopyrans and thiazolidinones
ChemInform Abstract: Desymmetrization of meso‐Aziridines with TMSNCS Using Metal Salts of Novel Chiral Imidazoline—Phosphoric Acid Catalysts.
Authors: Nakamura Shuichi , Ohara Mutsuyo , Koyari Madoka , Hayashi Masashi , Hyodo Kengo , Nabisaheb Nadaf Rashid , Funahashi Yasuhiro
Published: February 2015

Good enantioselectivities are achieved using a novel BINOL‐type catalyst for the reactions of aziridines with isothiocyanate (II) or thiobenzoic acid.
ChemInform Abstract: Visible Light‐Promoted Metal‐Free sp3‐C—H Fluorination.
Authors: Xia Ji‐Bao , Zhu Chen , Chen Chuo
Published: February 2015

This new fluorination method uses cheap and readily available acetophenone as the catalyst.
ChemInform Abstract: Synthesis of Heteroaryl Containing Sulfides via Enaminone Ligand Assisted, Copper‐Catalyzed C—S Coupling Reactions of Heteroaryl Thiols and Aryl Halides.
Authors: Liu Yunyun , Huang Bin , Cao Xiaoji , Wu Dan , Wan Jie‐Ping
Published: February 2015

Various title compounds (III), (VI), (IX) are obtained by C‐S cross coupling reactions between electron deficient heteroaryl thiols and aryl halides.
ChemInform Abstract: Pd(II)‐Catalyzed C—H Amination for N‐Heterocyclic Synthesis.
Authors: Jeong Eun Joo , Youn So Won
Published: February 2015

Optimum reaction conditions are examined for the title reaction which affords indole‐2‐carboxylic acid esters of type (II) or indazoles of type (IV) or (VI) or mixtures of isomers of type (VI) and (VIII).
ChemInform Abstract: Chemoselective Carbophilic Addition of α‐Diazoesters Through Ligand‐Controlled Gold Catalysis.
Authors: Xi Yumeng , Su Yijin , Yu Zhaoyuan , Dong Boliang , McClain Edward J. , Lan Yu , Shi Xiaodong
Published: February 2015

A gold‐catalyst with an electron‐deficient phosphite as the ancillary ligand is found to exclusively promote the carbophilic chemoselective addition of arenes, hetarenes and 1,3‐diketones to α‐aryldiazoesters.
ChemInform Abstract: Base‐Promoted Dehydrogenative Coupling of Benzene Derivatives with Amides or Ethers.
Authors: Ueno Ryota , Shirakawa Eiji
Published: February 2015

Benzene derivatives, e.g. (I), (V), (IX), and (XIII), bearing electron‐withdrawing groups as well as aromatic hydrocarbons, such as (XVI) and (XVIII), are introduced into the dehydrogenative coupling via homolytic aromatic substitution.
ChemInform Abstract: Diastereoselective Synthesis of Highly Substituted Polycyclic Scaffolds via a One‐Pot Four‐Step Tandem Catalytic Process.
Authors: Grafton Mark W. , Johnson Stuart A. , Farrugia Louis J. , Sutherland Andrew
Published: February 2015

A one‐pot four‐step multi‐reaction process involving a thermal Overman rearrangement, a tandem metathesis reaction, and a Diels—Alder reaction is developed for the diastereoselective synthesis of aminobicyclononanes and ‐decanes with up to five stereogenic centers.
ChemInform Abstract: Four‐Component Synthesis of β‐Enaminone and Pyrazole Through Phosphine‐Free Palladium‐Catalyzed Cascade Carbonylation.
Authors: Shi Lijun , Xue Liqin , Lang Rui , Xia Chungu , Li Fuwei
Published: February 2015

Carbonylative Sonogashira coupling of iodobenzenes with terminal alkynes is coupled with Michael addition of amines or phenylhydrazine in a one‐pot fashion, to generate either β‐enaminones or pyrazoles.
ChemInform Abstract: Nickel‐Catalyzed Multicomponent Coupling of Alkyne, Buta‐1,3‐diene, and Dimethylzinc under Carbon Dioxide.
Authors: Mori Yasuyuki , Mori Takamichi , Onodera Gen , Kimura Masanari
Published: February 2015

Depending on the substituents of the Zn‐reagent, the substituent as well as the alkyne is either incorporated into the product under formation of dienyl or monoenyl carboxylic acids or it acts as hydrogen‐transfer agent without insertion of the alkyne.
ChemInform Abstract: Photoinduced Sulfonylation of Cyclic Ethers.
Authors: Kamijo Shin , Hirota Masaki , Tao Keisuke , Watanabe Mizuki , Murafuji Toshihiro
Published: February 2015

A novel method for the synthesis of α‐sulfonylated cyclic ethers by a photoinduced reaction with sulfonyl chlorides is presented.
ChemInform Abstract: Stereoselective Construction of 1,3‐Disilylcyclopentane Derivatives by Scandium‐Catalyzed [3 + 2] Cycloaddition of Allylsilanes to β‐Silylenones.
Authors: Okamoto Kazuhiro , Tamura Eisuke , Ohe Kouichi
Published: February 2015

The reaction leads to a diastereoselective formation of multisubstituted cyclopentanes bearing 2 silicon groups in syn‐position.
ChemInform Abstract: Exploring the Vinylogous Reactivity of Cyclohexenylidene Malononitriles: Switchable Regioselectivity in the Organocatalytic Asymmetric Addition to Enals Giving Highly Enantioenriched Carbabicyclic Structures.
Authors: Dell'Amico Luca , Rassu Gloria , Zambrano Vincenzo , Sartori Andrea , Curti Claudio , Battistini Lucia , Pelosi Giorgio , Casiraghi Giovanni , Zanardi Franca
Published: February 2015

A two‐step, one‐pot sequence under chiral amine—NHC catalysis allows the approach to spiro[4.5]decanone structures in a diastereoselective manner with high e.e.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes.
Authors: Xiao Yu‐Lan , Guo Wen‐Hao , He Guo‐Zhen , Pan Qiang , Zhang Xingang
Published: February 2015

The first successful examples of Ni‐catalyzed difluoroalkylation of aryl boronic acids with difluoroalkyl bromides and chlorides is developed.
ChemInform Abstract: Clay‐Supported Copper Nitrate (Claycop): A Mild Reagent for the Selective Nitration of Aromatic Olefins.
Authors: Begari Eeshwaraiah , Singh Chandani , Nookaraju U. , Kumar Pradeep
Published: February 2015

The method is environmentally benign.
ChemInform Abstract: Indium‐Catalyzed Hydroamination/Hydrosilylation of Terminal Alkynes and Aromatic Amines Through a One‐Pot, Two‐Step Protocol.
Authors: Sakai Norio , Takahashi Nobuaki , Ogiwara Yohei
Published: February 2015

In a first hydroamination step the Markovnikov product is generated followed by hydrosilylation of the corresponding imine intermediate.
ChemInform Abstract: Rhodium‐Catalyzed [(3 + 2) + 1] Carbocyclization Reactions of Alkynylidenecyclopropanes with Carbon Monoxide: Regiospecific Construction of Polysubstituted Phenols.
Authors: Evans P. Andrew , Burnie Andrew J. , Negru Daniela E.
Published: February 2015

The title process allows the conversion of 1,6‐enynes into hetero‐ carbo‐5,6‐bicyclic systems.
ChemInform Abstract: Oxidative Cleavage of Benzylic C—N Bonds under Metal‐Free Conditions.
Authors: Gong Jin‐Long , Qi Xinxin , Wei Duo , Feng Jian‐Bo , Wu Xiao‐Feng
Published: February 2015

The first examples of a metal‐free oxidative cleavage of benzylic C—N bond using H2O2 as oxidant and Bu4NI as catalyst are reported.
ChemInform Abstract: Versatile and Sustainable Alcoholysis of Amides by a Reusable CeO2 Catalyst.
Authors: Siddik S. M. A. Hakim , Touchy Abeda Sultana , Tamura Masazumi , Shimizu Ken‐ichi
Published: February 2015

Volatile alcohols (VIII) are used in excess and in a sealed tube.
ChemInform Abstract: Copper‐Catalyzed Decarboxylative Sulfonylation of α,β‐Unsaturated Carboxylic Acids.
Authors: Rokade Balaji V. , Prabhu Kandikere Ramaiah
Published: February 2015

The reaction of various (E)‐configurated acid substrates with sulfinates (II) under conditions A) affords the pharmaceutically important vinyl sulfones as exclusive (E)‐ isomers.
ChemInform Abstract: Synthesis of Organic Carbonates with Alkyl/Aryl 4,5‐Dichloro‐6‐oxopyridazine‐1(6H)‐carboxylates and ROH/AlCl3 under Ambient Condition.
Authors: Sung Gi Hyeon , Kim Bo Ram , Ryu Ki Eun , Kim Jeum‐Jong , Yoon Yong‐Jin
Published: February 2015

The reaction of alcohols/AlCl3 with alkyl or aryl 4,5‐dichloro‐6‐oxopyridazine‐1(6H)‐carboxylates (II) yields the corresponding symmetric or unsymmetric carboxylates (III).
ChemInform Abstract: Ligand‐Assisted Copper‐Catalyzed Oxidative Cross‐Coupling of Simple Phenols with Formamides for the Synthesis of Carbamates.
Authors: Reddy Nagireddy Veera , Kumar Gadde Sathish , Kumar Pailla Santhosh , Kantam M. Lakshmi , Reddy Kallu Rajender
Published: February 2015

The method is applied to the synthesis of the insecticide dimetan (VII).
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of Unsymmetrical Arylurea Derivatives via Tandem Reaction of Diaryliodonium Salts with N‐Arylcyanamide.
Authors: Li Pengfei , Cheng Guolin , Zhang Hong , Xu Xianxiang , Gao Jingyuan , Cui Xiuling
Published: February 2015

An efficient one‐pot approach to multiple substituted ureas from N‐arylcyanamide and diaryliodonium salts is presented.
ChemInform Abstract: Magnetically Recoverable Nano‐Sized Mesoporous Solid Acid: Effective Catalysts for the Synthesis of 1‐Amidoalkyl‐2‐naphthols
Authors: Cai Zhixiang , Shu Chen , Peng Yanqing
Published: February 2015

via three‐component reaction of 2‐naphthol with aromatic aldehydes and benzamides (12 examples)
ChemInform Abstract: Copper(I) Bromide Catalyzed Arylation of Cyclic Enamides and Naphthyl‐1‐acetamides Using Diaryliodonium Salts.
Authors: Prakash Muthuraj , Muthusamy Subramaniam , Kesavan Venkitasamy
Published: February 2015

A direct, high‐yielding C—H arylation at position 2 of cyclic enamides of type (I) becomes possible in the presence of CuBr as the catalyst at room temperature.
ChemInform Abstract: Photoinduced Skeletal Rearrangement of Diarylethenes Comprising Oxazole and Phenyl Rings.
Authors: Lvov Andrey G. , Shirinian Valerii Z. , Kachala Vadim V. , Kavun Alexey M. , Zavarzin Igor V. , Krayushkin Mikhail M.
Published: February 2015

The photocyclization/rearrangement reaction of diarylethenes provides various substituted naphthalene derivatives.
ChemInform Abstract: Regiospecific Synthesis of 7‐Hydroxyindoles from Pyrroles by Anionic Benzannulation.
Authors: Dinda Bidyut Kumar , Basak Shyam , Mal Dipakranjan
Published: February 2015

Lithiation of pyrroles (I) and (XII) and subsequent reaction with a variety of Michael acceptors provides a regiocontrolled synthesis of 7‐hydroxyindole derivatives.
ChemInform Abstract: Cobalt‐Catalyzed Direct Carbonylation of Aminoquinoline Benzamides.
Authors: Grigorjeva Liene , Daugulis Olafs
Published: February 2015

A method for the cobalt catalyzed carbonylation of N‐(8‐quinolyl) substituted benzamides and acrylamides is developed using air as the oxidant in the presence of Mn(OAc)3 as promoter.
ChemInform Abstract: Metal‐Free One‐Pot Protocol for the Preparation of Unexpected Carbazole Derivative in Water: Easy Access to Pyrimidocarbazole and Pyridocarbazolone Derivatives.
Authors: Biswas Soumen , Majee Debashis , Dagar Anuradha , Samanta Sampak
Published: February 2015

Product (IIIa) is further transformed into pyrimidocarbazole (IV), a topoisomerase II inhibitor, and the pyrimidocarbazolone (V), the skeleton of a variety of natural products such as strychnos alkaloids.
ChemInform Abstract: Facile Synthesis of Pyrazoline Derivatized Amides via Sydnone Ring Cleavage.
Authors: Taj Tasneem , Kamble Ravindra R. , Marganakop Sheetal B.
Published: February 2015

Some of the title compounds exhibit excellent antitubercular activities and good antioxidant activities.
ChemInform Abstract: Three‐Component Coupling of Alkyl/Aryl Isocyanides, Acetylene Dicarboxylates and (2,4‐Dioxothiazolidin‐3‐yl)acetic Acids.
Authors: Sanaeishoar Tayebeh , Mohave Fouad
Published: February 2015

The title reaction delivers highly functionalized (E)‐products.
ChemInform Abstract: A Facile Route to the Synthesis of 1,3,4‐Oxadiazoline Derivatives.
Authors: Hassanabadi Alireza , Zhiani Rahele
Published: February 2015

For title synthesis of 1,3,4‐oxadiazoline derivatives some novel N‐acyl araldehyde hydrazone educts synthesized by known method are used.
ChemInform Abstract: A New Three‐Component Coupling Reaction of Aryl Glyoxal, Malononitrile, and 4‐Hydroxy Coumarin Catalyzed by Recyclable TiO 2 Nanoparticles.
Authors: Khodabakhshi Saeed , Shahamirian Mozhgan , Baghernejad Mojtaba
Published: February 2015

The title eco‐friendly and economic reaction furnishes some novel pyrano[3,2‐c]chromene‐5‐ones containing an aroyl substituent by using a recyclable and safe catalyst and a green solvent.
ChemInform Abstract: A Cooperative N‐Heterocyclic Carbene/Palladium Catalysis System.
Authors: Liu Kun , Hovey M. Todd , Scheidt Karl A.
Published: February 2015

Extensive studies are undertaken to find optimum reaction conditions and to gain insight into the mechanism of the formation of dihydrocoumarin derivatives (II) from aldehydes (I).
ChemInform Abstract: Synthesis of Novel Chromeno‐Annulated cis‐Fused Pyrano[3,4‐c]benzopyran and Naphtho Pyran Derivatives via Domino Aldol‐Type/Hetero Diels—Alder Reaction and Their Cytotoxicity Evaluation.
Authors: Madda Jyothi , Venkatesham Akkaladevi , Bejjanki Naveen Kumar , Kommu Nagaiah , Pombala Sujitha , Ganesh Kumar C. , Rao Tadikamalla Prabhakar , Nanubolu Jagadeesh Babu
Published: February 2015

Derivatives (IIIa), (IIIe), and (IIIf) exhibit promising cytotoxicity against different human cancer cell lines.
ChemInform Abstract: Polyhydroxyamino‐Piperidine‐Type Iminosugars and Pipecolic Acid Analogues from a D‐Mannose‐Derived Aldehyde.
Authors: Matassini Camilla , Mirabella Stefania , Ferhati Xhenti , Faggi Cristina , Robina Inmaculada , Goti Andrea , Moreno‐Clavijo Elena , Moreno‐Vargas Antonio J. , Cardona Francesca
Published: February 2015

Straightforward strategies for the synthesis of diversely functionalized polyhydroxy and polyhydroxyamino piperidines are presented, starting from aldehydes (I) or (V).
ChemInform Abstract: An Easy One‐Pot Synthesis of Diverse 2,5‐Di(2‐pyridyl)pyrroles: A Versatile Entry Point to Metal Complexes of Functionalized, Meridial and Tridentate 2,5‐Di(2‐pyridyl)pyrrolato Ligands.
Authors: McSkimming Alex , Diachenko Vera , London Rachel , Olrich Kiara , Onie C. Jessica , Bhadbhade Mohan M. , Bucknall Martin P. , Read Roger W. , Colbran Stephen B.
Published: February 2015

Although only moderate yields are obtained an easy one‐pot route to 2,5‐dipyridylpyrrole ligands (IV) is described.
ChemInform Abstract: Enantioselective Annulations for Dihydroquinolones by in situ Generation of Azolium Enolates.
Authors: Lee Anna , Younai Ashkaan , Price Christopher K. , Izquierdo Javier , Mishra Rama K. , Scheidt Karl A.
Published: February 2015

Substituents are tolerated in positions 4, 5, and 6 of the aminobenzyl chlorides, but not in position 3.
ChemInform Abstract: Regioselective Introduction of Heteroatoms at the C‐8 Position of Quinoline N‐Oxides: Remote C—H Activation Using N‐Oxide as a Stepping Stone.
Authors: Hwang Heejun , Kim Jinwoo , Jeong Jisu , Chang Sukbok
Published: February 2015

Alkyl‐ and arylazides are unreactive under the developed conditions.
ChemInform Abstract: A Highly Enantioselective Acyl‐Mannich Reaction of Isoquinolines with Aldehydes Promoted by Proline Derivatives: An Approach to 13‐Alkyl‐tetrahydroprotoberberine Alkaloids.
Authors: Mengozzi L. , Gualandi A. , Cozzi P. G.
Published: February 2015

The new method affords alkylated isoquinolines as diastereomeric mixtures with high enantioselectivities.
ChemInform Abstract: A Cascade Cross‐Coupling and in situ Hydrogenation Reaction by Visible Light Catalysis.
Authors: Zhong Jian‐Ji , Wu Cheng‐Juan , Meng Qing‐Yuan , Gao Xue‐Wang , Lei Tao , Tung Chen‐Ho , Wu Li‐Zhu
Published: February 2015

An interesting oxidative coupling of N‐aryltetrahydroisoquinolines with indoles to yield adducts of type (III) and (V) is developed.
ChemInform Abstract: Synthesis of Polysubstituted Phenanthridines via Ligand‐Free Copper‐Catalyzed Annulation.
Authors: Chen Yan‐Fu , Hsieh Jen‐Chieh
Published: February 2015

A novel synthesis of phenanthridines is developed utilizing the addition reaction of Grignard reagents to nitriles followed by copper‐catalyzed intramolecular C‐N bond coupling.
ChemInform Abstract: One‐Pot Synthesis of Highly Substituted Polyheteroaromatic Compounds by Rhodium(III)‐Catalyzed Multiple C—H Activation and Annulation.
Authors: Jayakumar Jayachandran , Parthasarathy Kanniyappan , Chen Yi‐Hsiang , Lee Tai‐Hua , Chuang Shih‐Ching , Cheng Chien‐Hong
Published: February 2015

Rh‐catalyzed reaction of N‐hydroxybenzamidines with an excess of internal alkynes and an excess of Cu(OAc)2 as the oxidant is described to produce polyhetarenes in good yields.
ChemInform Abstract: A New Route for the Synthesis of 6‐Substituted [1,2,4]Triazolo[4,3‐a]pyrimidines.
Authors: Krishnaraj Thulasiraman , Muthusubramanian Shanmugam
Published: February 2015

All new compounds (III) are tested for their antibacterial activities.
ChemInform Abstract: An Efficient Synthesis of 3H‐Pyrrolo[3,2‐d]pyrimidin‐4(5H)‐one Derivatives via an Iminophosphorane (I).
Authors: He Ping , Yan Yan‐Mei , Ding Ming‐Wu
Published: February 2015

Advantages of the new method are mild reaction conditions, good yields and easily changeable substituents.
ChemInform Abstract: Utility of 6‐Amino‐2‐thiouracils as a Core of Biologically Potent Polynitrogen—Sulfur Fused Heterocycles.
Authors: Rabie Samira T. , Abdel‐Monem Reham A. , Mohamed Nadia R. , Hashem Ahmed I. , Nada Afaf A.
Published: February 2015

A variety of new pyridopyrimidine derivatives are synthesized based on one‐pot three‐component reactions of 6‐amino‐2‐thiouracil derivatives (I) and (XIII).
ChemInform Abstract: One‐Pot NHC‐Assisted Access to 2,3‐Dihydropyrimido[4,5‐d]pyrimidin‐4(1H)‐ones.
Authors: Liu Mingxing , Li Jiarong , Chen Shu , Huang Danfei , Chai Hongxin , Zhang Qi , Shi Daxin
Published: February 2015

Target compounds (IV), (VI), (VIII), and (X) are prepared in high yields via a three‐component reaction between ketones (III) or (V) or benzaldehyde (IX), guanidines (I) or amidines (VII) and 2‐(ethoxymethylene)malononitrile (II) using 1,3‐dipropyl‐1,3‐dihydroimidazol‐2,2‐diyl as NHC catalyst.
ChemInform Abstract: NaSH in the Construction of Thiophene Ring Fused with N‐Heterocycles: A Rapid and Inexpensive Synthesis of Novel Small Molecules as Potential Inducers of Apoptosis.
Authors: Kolli Sunder Kumar , Nakhi Ali , Medishetti Raghavender , Yellanki Swapna , Kulkarni Pushkar , Ramesh Raju R. , Pal Manojit
Published: February 2015

The first examples of the use of NaSH to construct a thiophene ring fused with N‐heterocycles via a SnAr‐type reaction—cyclization strategies are given.
ChemInform Abstract: Synthesis of Homochiral Tetrahydropteridines.
Authors: Baker Stephen J. , Beresford Kenneth J. M. , Young Douglas W.
Published: February 2015

The synthesis of protected homochiral tetrahydropteridines with stereochemistry of natural coenzymes at C‐6 from (S)‐malic acid is reported.
ChemInform Abstract: [HCo(CO)4]‐Catalyzed Three‐Component Cycloaddition of Epoxides, Imines, and Carbon Monoxide: Facile Construction of 1,3‐Oxazinan‐4‐ones.
Authors: Liu Lixia , Sun Huailin
Published: February 2015

An efficient three‐component reaction of imines, epoxides and carbon monoxide is developed using HCo(CO)4 as in situ generated catalyst from Ph3Si‐Co(CO)4 and MeOH.
ChemInform Abstract: Synthesis of Pyrimido[2,1‐b][1,3,5]thiadiazines Containing Polyfluoroalkyl‐ and Amino Acid Fragments
Authors: Khudina O. G. , Ivanova A. E. , Burgart Ya. V. , Saloutin V. I.
Published: February 2015

by a multicomponent cyclization of 6‐polyfluoroalkyl‐2‐thiouracils with formaldehyde and amine or amino acids, respectively
ChemInform Abstract: σ‐Ferrier Rearrangement of Carbohydrate Derived Vinylcyclopropanes: A Facile Approach to Oxepane Analogues.
Authors: Ganesh Venkataraman , Kundu Taraknath , Chandrasekaran Srinivasan
Published: February 2015

A novel route to access functionalized oxepanes and 2‐deoxyseptanosides through Ferrier type ring‐expansion of carbohydrate based vinylcyclopropanes is developed.
ChemInform Abstract: Stereocontrolled Synthesis of 1,5‐Stereogenic Centers Through Three‐Carbon Homologation of Boronic Esters.
Authors: Unsworth Phillip J. , Leonori Daniele , Aggarwal Varinder K.
Published: February 2015

An efficient procedure for the three‐carbon homologation of pinacol boronic esters (I) is developed.
ChemInform Abstract: Asymmetric Synthesis of (‐)‐Pterosin N from a Chiral 1,3‐Dioxolanone.
Authors: Wu Hsiu‐Han , Hsu Shao‐Chien , Hsu Feng‐Lin , Uang Biing‐Jiun
Published: February 2015

The first asymmetric total synthesis of the sesquiterpene (‐)‐pterosin N is described.
ChemInform Abstract: Phorbaketals L—N, Cytotoxic Sesterterpenoids Isolated from the Marine Sponge of the Genus Phorbas.
Authors: Kang Heonjoong , et al. et al.
Published: February 2015

Phorbaketal N (III) shows potent cytotoxicity against human pancreas cancer cells.
ChemInform Abstract: Labdane Diterpenoids from the Roots of Amomum maximum and Their Cytotoxic Evaluation.
Authors: Luo Jian‐Guang , Yin Hong , Fan Bo‐Yi , Kong Ling‐Yi
Published: February 2015

Amomax A (I), B (II), and C (III) are isolated together with two known diterpenes.
ChemInform Abstract: Two New C‐seco Limonoids from the Fruit of Melia azedarach
Authors: Jin Qinghao , Lee Chul , Lee Jin Woo , Choi Jeong Yeon , Hong Jin Tae , Kim Youngsoo , Lee Mi Kyeong , Hwang Bang Yeon
Published: February 2015

isolation and structure elucidation
ChemInform Abstract: Winolides A—C, Bioactive Sesquiterpene Lactones with Unusual 5,6‐Secoeudesmane Frameworks from Inula wissmanniana.
Authors: Cheng Xiang‐Rong , Shao Wen‐Hao , Zhang Shou‐De , Wang Guo‐Wei , Shan Lei , Shen Yun‐Heng , Sun Qing‐Yan , Jin Hui‐Zi , Zhang Wei‐Dong
Published: February 2015

The isolation and structure elucidation of winolide A (Ia), B (Ib) and C (II) is described.
ChemInform Abstract: Merrilliadione — A Rare Isopropyl (13→11)‐abeo‐9,11‐seco Abietane Diterpene from Illicium merrillianum.
Authors: Tian Xinhui , Yue Rongcai , Zhang Shoude , Shen Yunheng , Ye Ji , Shan Lei , Li Huiliang , Wen Bo , Xu Xike , Zhang Weidong
Published: February 2015

The cytotoxic activity of merrilliadione (I) is moderate against several human cancer cell lines.
ChemInform Abstract: Reactions of 17‐Chloro‐16‐formylandrosta‐5,16‐diene with Thiohydrazides of Oxamic Acids.
Authors: Zavarzin I. V. , Antonov Ya. S. , Chernoburova E. I. , Shchetinina M. A. , Kolotyrkina N. G. , Shashkov A. S.
Published: February 2015

The title reaction smoothly affords the expected thiohydrazones (III).
ChemInform Abstract: Continuous Flow Synthesis of β‐Amino Acids from α‐Amino Acids via Arndt—Eistert Homologation.
Authors: Pinho Vagner D. , Gutmann Bernhard , Kappe C. Oliver
Published: February 2015

Two different approaches are developed ‐ the photochemical and silver‐catalyzed ones.
ChemInform Abstract: Gold(III) Chloride and Phenylacetylene: A Catalyst System for the Ferrier Rearrangement, and O‐Glycosylation of 1‐O‐Acetyl Sugars as Glycosyl Donors.
Authors: Roy Rashmi , Rajasekaran Parasuraman , Mallick Asadulla , Vankar Yashwant D.
Published: February 2015

A new catalyst system AuCl3/phenylacetylene is developed to promote the Ferrier rearrangement of glycals and the O‐glycosylation of 1‐O‐acetyl sugars.
ChemInform Abstract: Phosphoric Acid Catalyzed Desymmetrization of Bicyclic Bislactones Bearing an All‐Carbon Stereogenic Center: Total Syntheses of (‐)‐Rhazinilam and (‐)‐Leucomidine B.
Authors: Gualtierotti Jean‐Baptiste , Pasche Delphine , Wang Qian , Zhu Jieping
Published: February 2015

Desymmetrization of bislactones of type (I) with an alcohol in the presence of a chiral imidodiphosphonic acid as catalyst produces enantioenriched 4‐substituted‐4‐formylpimelate monoacids including Kuehne′s aldehyde (IIIa).
ChemInform Abstract: A Formal Synthesis of Herboxidiene/GEX1A.
Authors: Yadav Jhillu S. , Reddy G. Madhusudhan , Anjum S. Rehana , Reddy B. V. Subba
Published: February 2015

The formal asymmetric synthesis of the polyketide herboxidiene (I) is described.
ChemInform Abstract: A New Approach to Asymmetric Synthesis of Infectocaryone.
Authors: Liu Xiubing , Hu Lingling , Liu Xiaojing , Jia Junhao , Jiang Lizhen , Lin Jiangfeng , Chen Xiaochuan
Published: February 2015

A novel strategy for the synthesis of (‐)‐ and (+)‐infectocaryone from commercial sugars is described.
ChemInform Abstract: Lanthanides in the Frame of Molecular Magnetism
Authors: Gatteschi D.
Published: February 2015

Review: 39 refs.
ChemInform Abstract: Recent Developments of Solid Breeder Fabrication
Authors: Knitter R. , Chaudhuri P. , Feng Y. J. , Hoshino T. , Yu I.‐K.
Published: February 2015

Review: 25 refs.
ChemInform Abstract: Magnetic Clusters Based on Octacyanidometallates
Authors: Pinkowicz Dawid , Podgajny Robert , Nowicka Beata , Chorazy Szymon , Reczynski Mateusz , Sieklucka Barbara
Published: February 2015

Review: 173 refs.
ChemInform Abstract: Asymmetric Transformations of Achiral 2,5‐Cyclohexadienones
Authors: Kalstabakken Kyle A. , Harned Andrew M.
Published: February 2015

Review: [61 refs.
ChemInform Abstract: The Development for the Synthesis of Chiral Acyclic Nucleosides and Their Phosphonates
Authors: Xie Ming‐Sheng , Niu Hong‐Ying , Qu Gui‐Rong , Guo Hai‐Ming
Published: February 2015

Review: [23 refs.
ChemInform Abstract: The Ugi—Smiles and Passerini—Smiles Couplings: A Story About Phenols in Isocyanide‐Based Multicomponent Reactions
Authors: El Kaim Laurent , Grimaud Laurence
Published: February 2015

Review: [scope, mechanistic studies, and use of the title couplings for a variety of routes to fused aromatic systems; 48 refs.
ChemInform Abstract: Heterogeneous Foldamers from Aliphatic—Aromatic Amino Acid Building Blocks: Current Trends and Future Prospects
Authors: Nair Roshna V. , Vijayadas Kuruppanthara N. , Roy Arup , Sanjayan Gangadhar J.
Published: February 2015

Review: 105 refs.
ChemInform Abstract: Asymmetric Synthesis of Agrochemically Attractive Trifluoromethylated Dihydroazoles and Related Compounds under Organocatalysis
Authors: Kawai Hiroyuki , Shibata Norio
Published: February 2015

Review: [49 refs.
ChemInform Abstract: De Novo Design of Functional Oligonucleotides with Acyclic Scaffolds
Authors: Asanuma Hiroyuki , Kashida Hiromu , Kamiya Yukiko
Published: February 2015

Review: [65 refs.
ChemInform Abstract: Reductive Umpolung Reactions with Low‐Valent Titanium Catalysts
Authors: Streuff Jan
Published: February 2015

Review: [56 refs.
ChemInform Abstract: Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese~, and Indium Organometallics from Functionalized Organic Halides.
Authors: Dagousset Guillaume , Francois Cyril , Leon Thierry , Blanc Romain , Sansiaume‐Dagousset Elodie , Knochel Paul
Published: February 2015

Review: [149 refs.
ChemInform Abstract: Asymmetric Synthesis of Quaternary α‐Amino Acids and Their Phosphonate Analogues
Authors: Bera Kalisankar , Namboothiri Irishi N. N.
Published: February 2015

Review: [117 refs.
ChemInform Abstract: Recent Advances of Intermolecular Diels—Alder Reaction in Bio‐Inspired Synthesis of Natural Products
Authors: Wan Chun Yun , Deng Jun , Liu Hua , Bian Ming , Li Ang
Published: February 2015

Review: 20 refs.
ChemInform Abstract: Metal‐Catalyzed Synthesis of Heterocycles Bearing a Trifluoromethyl Group
Authors: Sodeoka Mikiko , Egami Hiromichi
Published: February 2015

Review: 134 refs.
ChemInform Abstract: Synthesis, Properties and Transformations of Fullerene Peroxides
Authors: Bulgakov R. G. , Galimov D. I. , Dzhemilev U. M.
Published: February 2015

Review: 143 refs.
ChemInform Abstract: Rotaxane Catalysts
Authors: Leigh David A. , Marcos Vanesa , Wilson Miriam R.
Published: February 2015

Review: 107 refs.
ChemInform Abstract: Design and Synthesis of 2α‐(Tetrazolylethyl)‐1α,25‐dihydroxyvitamin D3 as a High Affinity Ligand for Vitamin D Receptor
Authors: Matsuo Miki , Hasegawa Asami , Takano Masashi , Saito Hiroshi , Kakuda Shinji , Takagi Kenichiro , Ochiai Eiji , Horie Kyohei , Takimoto‐Kamimura Midori , Takenouchi Kazuya , et al. et al.
Published: February 2015

Review: 10 refs.
ChemInform Abstract: Review of Advanced Materials for Proton Exchange Membrane Fuel Cells
Authors: Kraytsberg Alexander , Ein‐Eli Yair
Published: February 2015

Review: 503 refs.
ChemInform Abstract: Applications of Supercritical Carbon Dioxide in Materials Processing and Synthesis
Authors: Zhang Xiaoxue , Heinonen Saara , Levaenen Erkki
Published: February 2015

Review: 117 refs.
ChemInform Abstract: Thin Metal Nanostructures: Synthesis, Properties and Applications
Authors: Fan Zhanxi , Huang Xiao , Tan Chaoliang , Zhang Hua
Published: February 2015

Review: 180 refs.
ChemInform Abstract: Mass Spectrometry Quantifies Protein Interactions — From Molecular Chaperones to Membrane Porins
Authors: Hopper Jonathan T. S. , Robinson Carol V.
Published: February 2015

Review: [86 refs.
ChemInform Abstract: Molecularly Imprinted Polymer Nanoparticles in Chemical Sensing ‐ Synthesis, Characterization and Application
Authors: Wackerlig Judith , Lieberzeit Peter A.
Published: February 2015

Review: 149 refs.
Wichard von Moellendorff
Authors: Evers Jürgen , Möckl Leonhard
Published: February 2015

Untersuchungen über die Vorgänge, die beim Verformen von Metallen und Legierungen ablaufen, waren im ersten Drittel des 20. Jahrhunderts zentrales Forschungsthema. Wichard von Moellendorff baute dazu im Kabelwerk Oberspree (KWO) der “Allgemeinen Elektricitätsgesellschat” (AEG) ein neues Industrie‐Labor auf. So konnte er sich mit systematischen metallographischen und mechanischen Untersuchungen an der wissenschaftlichen Auseinandersetzung über die Verformungsvorgänge beteiligen. 1913 leitete er zusammen mit Czochralski erste Vorstellungen über die Auswirkungen der Kristallinität auf die Verformungvorgänge ab. Seine Deutungen waren zunächst im Widerspruch zu gängigen wissenschaftlichen Auffassungen, setzten sich dann aber als richtig durch. Nach einer Auszeit während des Ersten Weltkriegs setzte er diese Forschung als Direktor des Staatlichen Materialprüfungsamtes und gleichzeitig des Kaiser‐Wilhelm‐Instituts für Metallforschung in Berlin‐Dahlem fort und untersuchte die Form der Fließkegel, die beim mechanischen Zerreißen von Metallstäben entstehen. Diese Vorgänge ließen sich 1929 durch “Drehung, Verzerrung und Gleitung kristallographischer Gleitebenen” deuten. Polany befasste sich ab 1923 mit röntgenographischen und mechanischen Untersuchungen der Verformungsvorgänge. 1932 gelang ihm der wissenschaftliche Durchbruch über einen Versetzungsmechanismus. Demnach werden einzelne Atome auf Zwischenpositionen verschoben und bewegen sich dann schrittweise durch den Kristall. 1933 verließ Polanyi wegen seiner jüdischen Abstammung Nazi‐Deutschland; Moellendorff gehört zu den wenigen der deutschen wissenschaftlichen und technischen Elite, die sich mutig dem Nazi‐Regime entgegengestellten.
Evaluation of M‐xylene ammoxidation at bench‐scale operation in the presence of V2O5/Γ‐Al2O3 catalyst
Authors: Jeon Yukwon , Row Sung wook , Park Sang sun , Lee Sang Duek , Oh Kyeongseok , Shul Yong‐Gun
Published: February 2015

A bench‐scale ammoxidation reaction of m‐xylene was evaluated in the presence of V2O5/γ‐Al2O3 catalyst. The experiment was performed in a packed‐bed reactor with 25 mm i.d. using 200 g of catalyst. To alleviate sudden temperature hikes during ammoxidation, molten salt system was carefully built in the outer part of the reactor in a jacket‐type. Higher value of heat capacity of molten salt led to the stabilized reaction temperature within tolerable ranges without significant deactivation of catalytic activity. Isophthalonitrile (IPN) was a main product to compare reaction performance, while m‐tolunitrile, even hardly observed in a lab‐scale experiment, was a noticeable by‐product in this study. Reaction parameters include reaction temperature, oxygen to m‐xylene ratio, NH3 to m‐xylene ratio, and gas hourly space velocity. The selectivity of IPN over m‐tolunitrile was clearly improved when reaction temperature was raised from 320 to 380 °C. For a long‐term test, the reaction was evaluated in the period of one year. The catalyst was characterized before and after the long‐term experiment and its changes were analyzed by N2‐physisorption, SEM, XRD and XPS.