bluuebunny/crossref_metadata_2025 huggingface dataset:
“Damned If You Do, Damned If You Don’t”: Perceived Discrimination and the Paradoxes of Assimilation among U.S. Muslims
Authors: Vaughan Kenneth , Park Jerry Z. , Tom Joshua Christopher , Yilmaz Murat
Published: August 2022

Muslim Americans are a fast-growing minority group within the United States, both demographically and in the public consciousness. National surveys place them among the least liked groups in the U.S. cultural landscape, and throughout the twenty-first century they have often been the target of both high-profile vitriol and common daily abuses. We use logistic regression analyses of nationally representative data from the Pew Research Center’s 2011 Survey of American Muslims to better understand the social predictors of experiencing discrimination among American Muslims. Integrating these analyses with existing literature on minority group assimilation, we find that both patterns of assimilation and resistance to assimilation positively predict experiences of discrimination. These results suggest that American Muslims face no unequivocal path away from discriminatory experiences and inhabit a precarious place where assimilation presents more opportunities for exposure to discrimination and resistance to assimilation leads to sanctions from the dominant culture.
How to sign on and stay there: Snapshot of the feeling of belonging within the Irish Deaf Community
Authors: Conama John Bosco
Published: August 2022

This article seeks to explore the notion and strength of community belonging amongst the deaf community in Ireland. The article outlines the results from the online and anonymous survey that took place in June 2020. Three hundred ninety-nine responses were made, and 270 out of them are fully completed and analysed before a commentary is made. Concepts such as the “community” and “deaf community” are briefly theorised to see if they are compatible with the community beliefs held by the respondents. Key issues that are perceived to unite or divide the deaf community include solidarity, cultural affinity, sense of belonging, lack of trustworthiness, feelings of exclusion and dissent regarding leadership. The theoretical concept of ‘sense of community’ adapted is that proposed by McMillian and Chavis (1986), who define it as “a feeling that members have of belonging, a feeling that members matter to one another and the group, and a shared faith that members’ needs will be met through their commitment to being together.” It is envisaged to have the research expanded into specific issues such as the long-term sustainability of the community.
Sertraline-Induced Tics: A Case Report and Narrative Review
Authors: Arasu Ramesh , Badeshae Semran , Furlong Yulia , Chen Wai
Published: August 2022

This brief report describes the case of a 16-year-old girl who was commenced on sertraline for anxiety and depression, and subsequently developed severe and debilitating motor tics. Cessation of sertraline was associated with the resolution of tics; after this, paroxetine was trialled and well tolerated with good response of targeted symptoms and without re-emergence of tics. A narrative literature review yielded a retrospective observational study and eight single case reports on selective serotonin receptor inhibitor-induced motor tics (three in adolescents and five in adults). Tics are not commonly considered as a side-effect of SSRIs. This case report is novel is several aspects: the tics emergence was immediate whereas previous cases were delayed; the tics symptoms were measured and quantified by a validated scale; a dose-response relationship was observed; to our knowledge, our case was the first adolescent female reported; and finally, paroxetine was well-tolerated as a substitute, although it is unclear whether the observed tics-sparing effect is co-incidental, ideocratic or can be replicated.
Foundations of Influence: Intervention Pathways of Foundation Influence on City Governance and Policy
Authors: Thomson Dale E.
Published: August 2022

Philanthropic foundations have assumed prominent roles in revitalizing distressed U.S. cities raising questions about their ongoing effects on governance and policy, institutions, access to decision-making, and outcomes. This exploratory, qualitative study examines foundation interventions in eight cities where foundations account for a substantial share of community and economic development financing. Foundations have significantly altered interventions which, when combined with their substantial giving and government austerity, significantly increases their potential for enduring influence on city governance and policymaking and fosters the growth of nonprofit governance in these cities.
Exploring Latino Perspectives in Childhood Fever: Beliefs, Practices, and Needs
Authors: Acorda Darlene E. , Engebretson Joan , DesOrmeaux Christina , Cuccaro Paula , Rozmus Cathy
Published: August 2022

Introduction:

Latino parents have significant knowledge gaps and misconceptions about fever. In this study, we explored Latino beliefs and practices around fever and its impact on their care decisions.

Methods:

A qualitative-focused ethnography was conducted with 21 Latino parents. Semi-structured interviews were completed, and inductive thematic analysis was used to identify themes and subthemes.

Results:

Three major themes emerged: (a) the meaning of fever; (b) seeking guidance; and (c) navigating fever. Subthemes included: a sign of folk illness, a sign of infection, trust in health care providers, watchful waiting, and barriers and needs.

Discussion:

Latino parents have significant knowledge gaps about the role of fever in illness. They engage multiple systems of care but rarely share their fears with health care providers. Culturally-sensitive interventions incorporating traditional and biomedical approaches are needed. Findings can help inform future interventions targeting knowledge gaps in this population.
Screening of Pathogenic Missense Single Nucleotide Variants From LHPP Gene Associated With the Hepatocellular Carcinoma: An In silico Approach
Authors: Mahmood Malik Siddique , Afzal Maryam , Batool Hina , Saif Amara , Aqdas Tahreem , Ashraf Naeem Mahmood , Saleem Mahjabeen
Published: August 2022

LHPP gene encodes a phospholysine phosphohistidine inorganic pyrophosphate phosphatase, which functions as a tumor-suppressor protein. The tumor suppression by this protein has been confirmed in various cancers, including hepatocellular carcinoma (HCC). LHPP downregulation promotes cell growth and proliferation by modulating the PI3K/AKT signaling pathway. This study identifies potentially deleterious missense single nucleotide variants (SNVs) associated with the LHPP gene using multiple computational tools based on different algorithms. A total of 4 destabilizing mutants are identified as L22P, I212T, G227R, and G236R, from the conserved region of the phosphatase. The 3-dimensional (3D) modeling and structural comparison of variants with the native protein reveals significant structural and conformational variations after mutations, suggesting disruption in the function of phospholysine phosphohistidine inorganic pyrophosphate phosphatase. The identified mutations might, therefore, participate in the cause of HCC.
Asymmetry analysis of rolling contact for the heavy load radial tyre
Authors: Liu Zhihao , Liu Yixun , Gao Qinhe
Published: August 2022

A flexible carcass ring model with a two-dimensional elastic foundation that combined a flexible carcass ring and a two-dimensional spring element was used to analyze the contact boundary of heavy load radial tyres with a large section ratio. A complete tyre model based on the flexible ring was established and the contact features were studied by solving the theoretical boundary for its contact and non-contact zones. The contact stiffness and imprint were validated in rolling and stiffness experiments. The scope for contact estimation was examined by using an in-tyre strain sensor and the influence of the axle load, inflation pressure and rolling speed on the asymmetry of the contact imprint was analyzed. The experimental and theoretical results show that the contact front/rear angle and contact imprint can be estimated exactly by computing the contact boundary. In-tyre strain signals can be further used to estimate the length of the contact imprint. This research can be used to enrich existing simplified physical tyre models.
Symbolic kraals: Subterranean food stores, hidden wealth and ethnographic errors
Authors: Russell Thembi
Published: August 2022

Iron Age studies in South Africa are dominated by Huffman’s (1982, 1986, 1993, 2001) ethnographically derived Central Cattle Pattern model, which identifies the cattle-based bridewealth institution of South Eastern Bantu-language speakers by the spatial distribution of specific archaeological features. The idea of the spatial expression ‘on the ground’ of a variety of symbolic codes was Adam Kuper’s (1980, 1982) interpretation of predominantly Swazi ethnography. Surprisingly, Kuper’s work has never been interrogated and consequently his misunderstanding of the ethnography was carried into the Central Cattle Pattern and interpretations of the last 1600 years of Iron Age, farmer archaeology in southern Africa. Two particular features, burials and subterranean grain storage pits, and their relationship to cattle-kraals are explored. Because cattle are central to the Central Cattle Pattern, much archaeological attention has been given to looking for evidence of cattle at archaeological sites, either by dung, bones or cattle-kraals. The paper presents the views of contemporary Swazi, Xhosa and Mfengu people that suggest the symbolic importance of cattle-kraals; in the extreme they may not reflect the presence of livestock at all, yet their persisting presence demonstrates the continuing importance of cattle, real or imagined.
Recent insights into the role of microbiome in the pathogenesis of obesity
Authors: van der Vossen Eduard W. J. , de Goffau Marcus C. , Levin Evgeni , Nieuwdorp Max
Published: August 2022

Obesity is a risk factor for many chronic diseases and its rising prevalence the last couple of decades is a healthcare concern in many countries. Obesity is a multifactorial problem that is not only limited in its causation by diet and lack of exercise. Genetics but also environmental factors such as the gut microbiome should similarly be taken into account. A plethora of articles have been published, that from various different angles, attempt to disentangle the complex interaction between gut microbiota and obesity. Examples range from the effect of the gut microbiota on the host immune system to the pathophysiological pathways in which microbial-derived metabolites affect obesity. Various discordant gut microbiota findings are a result of this complexity. In this review, in addition to summarizing the classical role of the gut microbiome in the pathogenesis of obesity, we attempt to view both the healthy and obesogenic effects of the gut microbiota as a consequence of the presence or absence of collective guilds/trophic networks. Lastly, we propose avenues and strategies for the future of gut microbiome research concerning obesity.
The Association between Late-Life Alcohol Consumption and Incident Dementia among Mexican Americans Aged 75 and Older
Authors: Villarreal Rizzo Alan F. , Downer Brian
Published: August 2022

Background: Evidence for late-life alcohol consumption being associated with reduced dementia risk is largely based on cohort studies of predominately non-Hispanic white older adults. Our objective was to investigate the relationship between late-life alcohol consumption and dementia risk among Mexican-America adults aged 75 and older. Methods: This study was a retrospective analysis of waves 5 (2004/05) to 8 (2012/13) of the Hispanic Established Populations for the Epidemiologic Study of the Elderly. The final sample included 1,255 participants. Late-life alcohol consumption status was classified as life-long abstainer, former drinker, and current drinker. Dementia was defined as a score of 18 points or lower on the Mini-Mental Status Examination or a proxy-reported diagnosis of dementia. Results: 41.8% of participants were life-long abstainers, 42.0% were former drinkers, and 16.3% were current drinkers. Current alcohol consumers had significantly lower dementia risk compared to life-long abstainers (HR=0.63, 95% CI = 0.44–0.89). Dementia risk for former alcohol consumers compared to life-long abstainers was not statistically significant (HR = 0.85, 95% CI = 0.67–1.09). Conclusions: Current alcohol consumption was associated with lower dementia risk for Mexican Americans aged 75 and older. Continued research is needed to identify pathways for the protective association between late life alcohol consumption and dementia risk.
“yeet nitro boosted”: A Postdigital Perspective on Young People’s Literacy Engagements With the Discord Platform
Authors: Robinson Bradley
Published: August 2022

While the influence of digital technologies on literacy expression has long been a central concern of literacy studies, the proliferation of digital platforms across contemporary life has prompted increased scholarly attention to their influence on literacy. How, this scholarship asks, do platforms’ interfaces, algorithms, and business models produce particular formations of literacy, and what do those formations mean for ethical and equitable literacies learning and living? To reckon with these questions, this article brings a postdigital literacies perspective to data collected at the Giga-Games Camp, a video game design summer camp, where young people interacted with each other using Discord, a social media platform. The author describes how the Giga-Gamers and the Discord platform engaged in the mutually articulated platform practice of economics and argues that attention to such platform practices can help educators and researchers respond to the economic forces (re)shaping literacy in the platform society.
Challenges in the successful management of asthma during conception, pregnancy and delivery
Authors: Gade Elisabeth J. , Tidemandsen Casper , Hansen Anne V. , Ulrik Charlotte S. , Backer Vibeke
Published: August 2022

Asthma and infertility are the most common disorders among women of reproductive age. Time to pregnancy is prolonged in women with asthma, and importantly, age seems to be a more important risk factor regarding fertility in women with asthma compared to women without asthma. Some data have shown a higher frequency of miscarriages in women with asthma, although the data are conflicting on this issue as studies have observed no association between asthma and pregnancy loss. Furthermore, studies have shown no negative effect of asthma on the total number of offspring. Pregnancy may, thus, have a significant impact on women with asthma, as well as on their offspring.

The age of the women has an important impact on ability to conceive, but also for the pregnancy itself, with higher risk of uncontrolled asthma as well as asthma exacerbations with increasing age. Well-controlled asthma decreases the risk of maternal and fetal complications, while poorly controlled and undertreated asthma is associated with a range of risks for both mother and fetus. Asthma treatment should follow the general guidelines for asthma therapy, irrespective of pregnancy status, including treatment with inhaled corticosteroids, β2-agonists and muscarinic antagonists. Targeted treatment with biologics for severe asthma seems to be without important adverse effects. The use of systemic corticosteroids may be associated with adverse events during the first trimester; however, an exacerbation with the associated risk of hypoxaemia is worse for the fetus. Best possible asthma control may be achieved using repeated measurements of fractional exhaled nitric oxide (FENO), as the use ofFENOcompared with symptoms registration only has been shown to reduce exacerbation rate.

In conclusion, women with asthma should be encouraged to conceive at an early age, might experience miscarriages, but the number of offspring are the same as in women without asthma. Well treated asthma is important for the well-being of both the mother and the unborn fetus.
Towards reliable whole genome sequencing for outbreak preparedness and response
Authors: Nieuwenhuijse David F. , van der Linden Anne , Kohl Robert H. G. , Sikkema Reina S. , Koopmans Marion P. G. , Oude Munnink Bas B.
Published: August 2022

Background

To understand the dynamics of infectious diseases, genomic epidemiology is increasingly advocated, with a need for rapid generation of genetic sequences during outbreaks for public health decision making. Here, we explore the use of metagenomic sequencing compared to specific amplicon- and capture-based sequencing, both on the Nanopore and the Illumina platform for generation of whole genomes of Usutu virus, Zika virus, West Nile virus, and Yellow Fever virus.

Results

We show that amplicon-based Nanopore sequencing can be used to rapidly obtain whole genome sequences in samples with a viral load up to Ct 33 and capture-based Illumina is the most sensitive method for initial virus determination.

Conclusions

The choice of sequencing approach and platform is important for laboratories wishing to start whole genome sequencing. Depending on the purpose of genome sequencing the best choice can differ. The insights presented in this work and the shown differences in data characteristics can guide labs to make a well informed choice.
Comparative transcriptome analysis linked to key volatiles reveals molecular mechanisms of aroma compound biosynthesis in Prunus mume
Authors: Xiujun Wang , Zhenqi Song , Yujing Ti , Kaifeng Ma , Qingwei Li
Published: August 2022

Background

Mei (Prunus mume) is the only woody plant in the genus Prunus with a floral fragrance, but the underlying mechanisms of aroma compound biosynthesis are unclear despite being a matter of considerable interest.

Results

The volatile contents of the petals of two cultivars with significantly different aromas, Prunus mume ‘Xiao Lve’ and Prunus mume ‘Xiangxue Gongfen’, were characterised by GC-MS at different flowering periods, and a total of 44 volatile compounds were detected. Among these, the main substances forming the typical aroma of P. mume were identified as eugenol, cinnamyl acetate, hexyl acetate and benzyl acetate, with variations in their relative concentrations leading to sensory differences in the aroma of the two cultivars. We compiled a transcriptome database at key stages of floral fragrance formation in the two cultivars and used it in combination with differential analysis of floral volatiles to construct a regulatory network for the biosynthesis of key aroma compounds. The results indicated that PmPAL enzymes and PmMYB4 transcription factors play important roles in regulating the accumulation of key biosynthetic precursors to these compounds. Cytochrome P450s and short-chain dehydrogenases/reductases might also influence the biosynthesis of benzyl acetate by regulating production of key precursors such as benzaldehyde and benzyl alcohol. Furthermore, by analogy to genes with verified functions in Arabidopsis, we predicted that three PmCAD genes, two 4CL genes, three CCR genes and two IGS genes all make important contributions to the synthesis of cinnamyl acetate and eugenol in P. mume. This analysis also suggested that the downstream genes PmBGLU18-like, PmUGT71A16 and PmUGT73C6 participate in regulation of the matrix-bound and volatile states of P. mume aroma compounds.

Conclusions

These findings present potential new anchor points for further exploration of floral aroma compound biosynthesis pathways in P. mume, and provide new insights into aroma induction and regulation mechanisms in woody plants.
Detection of primary Sjögren’s syndrome in primary care: developing a classification model with the use of routine healthcare data and machine learning
Authors: Dros Jesper T. , Bos Isabelle , Bennis Frank C. , Wiegersma Sytske , Paget John , Seghieri Chiara , Barrio Cortés Jaime , Verheij Robert A.
Published: August 2022

Background

Primary Sjögren’s Syndrome (pSS) is a rare autoimmune disease that is difficult to diagnose due to a variety of clinical presentations, resulting in misdiagnosis and late referral to specialists. To improve early-stage disease recognition, this study aimed to develop an algorithm to identify possible pSS patients in primary care. We built a machine learning algorithm which was based on combined healthcare data as a first step towards a clinical decision support system.

Method

Routine healthcare data, consisting of primary care electronic health records (EHRs) data and hospital claims data (HCD), were linked on patient level and consisted of 1411 pSS and 929,179 non-pSS patients. Logistic regression (LR) and random forest (RF) models were used to classify patients using age, gender, diseases and symptoms, prescriptions and GP visits.

Results

The LR and RF models had an AUC of 0.82 and 0.84, respectively. Many actual pSS patients were found (sensitivity LR = 72.3%, RF = 70.1%), specificity was 74.0% (LR) and 77.9% (RF) and the negative predictive value was 99.9% for both models. However, most patients classified as pSS patients did not have a diagnosis of pSS in secondary care (positive predictive value LR = 0.4%, RF = 0.5%).

Conclusion

This is the first study to use machine learning to classify patients with pSS in primary care using GP EHR data. Our algorithm has the potential to support the early recognition of pSS in primary care and should be validated and optimized in clinical practice. To further enhance the algorithm in detecting pSS in primary care, we suggest it is improved by working with experienced clinicians.
The Otago Exercise Program compared to falls prevention education in Zuni elders: a randomized controlled trial
Authors: Waters Debra L. , Popp Janet , Herman Carla , Ghahate Donica , Bobelu Jeanette , Pankratz Vernon S. , Shah Vallabh O.
Published: August 2022

Background

When a Zuni elder sustains a fall-related injury, the closest tribal skilled nursing facility is 100 miles from the Pueblo and no physical therapy services are available. Thus, fall prevention strategies as a primary intervention to avert injurious falls and preserve aging in place are needed. The objective of the study is to compare the effectiveness of a community health representative (CHR)-delivered, culturally-adapted Otago Exercise Program (OEP) fall prevention program compared to the standard of care education-based fall risk management.

Methods

“Standing Strong in Tribal Communities: Assessing Elder Falls Disparity” is mixed-methods research with a randomized controlled trial. The CHRs will be trained to deliver the culturally-adapted OEP trial and offer advantages of speaking “Shiwi” (Zuni tribal language) and understanding Zuni traditions, family structures, and elders’ preferences for receiving health information. Focus groups will be conducted to assure all materials are culturally appropriate, and adapted. A physical therapist will train CHRs to screen elders for falls risk and to deliver the OEP to the intervention group and education to the control group. Up to 400 Zuni elders will be screened by the CHRs for falls risk and 200 elders will be enrolled into the study (1:1 random allocation by household). The intervention is 6 months with measurements at baseline, 3, 6 and 12 months. The primary outcome is improved strength and balance (timed up and go, sit to stand and 4 stage balance test), secondary outcomes include falls incidence, self-efficacy using Attitudes to Falls-Related Interventions Scale, Medical Outcomes Study Short Form 12 (SF-12v2) and Self-Efficacy for Managing Daily Activities.

Discussion

Fall prevention for Zuni elders was identified as a tribal priority and this trial is built upon longstanding collaborations between the investigative team, Zuni tribal leaders, and multiple tribal health programs. Delivery by the CHRs make this model more acceptable, and thus, more sustainable long term. This study has the potential to change best practice for elder care in tribal and rural areas with limited access to physical therapist-delivered fall prevention interventions and aligns with tribal goals to avert fall-related injury, reduce healthcare disparity, and preserve elder’s independence.

Trial registration

NCT04876729
Responsiveness level and its effect on services quality from the viewpoints of the older adults hospitalized during COVID-19 pandemic
Authors: Yusefi Ali Reza , Davarani Esmat Rezabeigi , Daneshi Salman , Bastani Misagh , Mehralian Gholamhossein , Bastani Peivand
Published: August 2022

Background

Aging is a sensitive period of life. Attention to the needs of this stage is considered a social necessity. This study is conducted to investigate the responsiveness level and its effect on service quality from the hospitalized older adults’ viewpoints during the COVID-19 pandemic in the south of Iran.

Methods

It was a cross-sectional descriptive-analytic study that was conducted on 386 old patients. The study instrument was a standard questionnaire that includes three sections of demographic information, World Health Organization Responsiveness, and SERVQUAL. Data were analyzed applying descriptive and inferential statistics the same as Independent T-test, ANOVA, Pearson correlation, and multiple linear regression.

Results

The mean levels of responsiveness and service quality were 90.72 ± 9.38 (from 160) and 68.01 ± 8.51 (from 110) respectively. This indicates the average level of these variables from the old patients’ viewpoints. There was a significant positive correlation between responsiveness and service quality (r = 0.585). According to the results of multiple linear regression, the dimensions of communication, dignity, prompt attention, primary facilities, social support, information confidentiality, right to choose, and autonomy were identified as the predictors of service quality.

Conclusion

The average level of responsiveness and service quality perceived from the old patients’ viewpoints during the COVID-19 pandemic can be considered a necessity for supportive planning among the older adults. Meanwhile, according to the impacts of responsiveness on service quality, educational programs are recommended to promote the level of healthcare providers’ responsiveness.
Early diagnosis of spinal tuberculosis by magnetic resonance: perfusion weighted imaging in a rabbit model
Authors: Liu Xiaochen , Wang Yunlin , Jia Wenxiao
Published: August 2022

Background

This study aimed to analyze the application value of magnetic resonance (MR)-perfusion weighted imaging (PWI) in the early imaging diagnosis of rabbit spinal tuberculosis.

Methods

Spinal tuberculosis model was established using ATCC25177 Mycobacterium tuberculosis strain in the lumbar spine of rabbits. Forty rabbits were divided into 2 groups: rabbits in the experiment group were injected with 0.2 ml of 5.0 mg/ml tuberculosis suspension (n = 30) and those in the control group were injected with 0.2 ml of normal saline (n = 10) after vertebrae drilling surgery. Routine MRI and MR-PWI were performed at 4, 6, and 8 weeks after surgery. The statistical difference in terms of perfusion parameter values in the early MR-PWI scan of spinal tuberculosis between two groups was analyzed. The receiver operating characteristic (ROC) curve analysis was conducted for the accuracy of MR-PWI parameters in the early diagnosis of spinal tuberculosis.

Results

Except time to peak, the other perfusion parameters in the experiment group were all increased with time. In addition, the difference between the two groups, as well as the differences at each time point was statistically significant (all P < 0.05). First-pass enhancement rate (Efirst), early enhancement rate (Ee), peak height (PH), maximum slope of increase (MSI), maximum signal enhancement rate (Emax) and signal enhancement rate (SER) showed high values in early diagnosing spinal tuberculosis.

Conclusion

The parameters including Efirst, Ee, PH, MSI, Emax and SER may provide valuable imaging evidence for the early diagnosis of spinal tuberculosis in clinical application.
Lambda light chain-induced monoclonal gammopathy of renal significance, manifesting with Fanconi Syndrome and osteomalacia
Authors: Gutiérrez-Peredo Gabriel Brayan , Filho José César Batista Oliveira , Montaño-Castellón Iris , Gutiérrez-Peredo Andrea Jimena , Crusoé Edvan de Queiroz , Gusmao-Flores Dimitri
Published: August 2022

Background

Monoclonal gammopathy of renal significance (MGRS) encompasses a heterogeneous group of kidney diseases in which a monoclonal immunoglobulin secreted by a clone of B cells or plasma cells causes kidney damage without meeting the hematological criteria for malignancy. Among the various forms of involvement, MGRS can manifest as a proximal tubule disorder, such as Fanconi syndrome (FS), characterized by urinary loss of phosphate, glucose, amino acids, uric acid and bicarbonate. Few cases of MGRS have been described in the literature, manifesting as FS and monoclonal production of lambda light chains, almost all of which are secondary to the production of kappa light chains.

Case presentation

Here we report a clinical case of a 45-year-old Brazilian male, African descent, with proximal weakness of the lower limbs, whose initial assessment showed a urine summary with the presence of proteinuria and glycosuria without hyperglycemia, associated with mild worsening of renal function, hypouricemia, hypocalcemia and phosphaturia. Evolution was characterized by a MGRS manifesting as FS and osteomalacia.

Conclusion

The diagnosis of MGRS is not always easy, it requires knowledge of the clinical characteristics, diagnostic criteria and prognosis of each case. Therefore, all possible efforts should be made for multidisciplinary diagnosis.
Efficacy of a transdiagnostic guided internet-delivered intervention for emotional, trauma and stress-related disorders in Mexican population: study protocol for a randomized controlled trial
Authors: de la Rosa-Gómez Anabel , Flores-Plata Lorena A. , Esquivel-Santoveña Esteban E. , Santillán Torres Torija Carolina , García-Flores Raquel , Dominguez-Rodriguez Alejandro , Arenas-Landgrave Paulina , Castellanos-Vargas Rosa O. , Berra-Ruiz Enrique , Silvestre-Ramírez Rocío , Miranda-Díaz Germán Alejandro , Díaz-Sosa Dulce M. , Hernández-Posadas Alejandrina , Flores-Elvira Alicia I. , Valencia Pablo D. , Vázquez-Sánchez Mario F.
Published: August 2022

Background

Emotional and stress-related disorders show high incidence, prevalence, morbidity, and comorbidity rates in Mexico. In recent decades, research findings indicate that cognitive behavioral interventions, from a disorder-specific perspective, are the effective front-line treatment for anxiety and depression care. However, these treatments are not often used. Reasons include limited access and low availability to effective interventions and comorbidity between mental disorders. Emotional deregulation of negative affectivity has been found to be a mediating factor in addressing emotional disorders from a transdiagnostic perspective, aimed at two or more specific disorders. In addition, technological advancement has created alternatives for psychological assistance, highlighting the possibilities offered by technologies since Internet-supported intervention programs have been empirically tested for effectiveness, efficiency and efficacy and can be key to ensuring access to those who are inaccessible. The aim of the study is to evaluate the efficacy, moderators of clinical change and acceptability of a transdiagnostic guided Internet-delivered intervention versus a transdiagnostic self-guided Internet-delivered intervention for emotional, trauma and stress-related disorders, and waiting list in community sample.

Methods

A three-armed, parallel group, superiority randomized controlled clinical trial with repeated measurements at four times: pretest, posttest, follow-up at 3, 6 and 12 months. Outcomes assessor, participant, care provider and investigator will be blinded. Participants aged 18 to 70 years will be randomly allocated 1:1:1 to one of three study arms: a) Transdiagnostic guided internet-delivered intervention with synchronous assistance, b) Transdiagnostic self-guided internet-delivered intervention, c) Waiting list group. Based on sample size estimation, a minimum of 207 participants (69 in each intervention group) will be included.

Discussion

The study could contribute to improving the efficacy of transdiagnostic internet-delivered interventions to promote the dissemination of evidence-based treatments and eventually, to decrease the high prevalence of emotional and trauma-related disorders in the Mexican population.

Trial registration

ClinicalTrial.gov: NCT05225701. Registered February 4, 2022.
Development and validation of a prognostic nomogram among patients with acute exacerbation of chronic obstructive pulmonary disease in intensive care unit
Authors: Peng Jiang-Chen , Gong Wen-Wen , Wu Yan , Yan Tian-Yi , Jiang Xiao-Yan
Published: August 2022

Background

Acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) contributes significantly to mortality among patients with COPD in Intensive care unit (ICU). This study aimed to develop a nomogram to predict 30-day mortality among AECOPD patients in ICU.

Methods

In this retrospective cohort study, we extracted AECOPD patients from Medical Information Mart for Intensive Care III (MIMIC-III) database. Multivariate logistic regression based on Akaike information criterion (AIC) was used to establish the nomogram. Internal validation was performed by a bootstrap resampling approach with 1000 replications. The discrimination and calibration of the nomogram were evaluated by Harrell’s concordance index (C-index) and Hosmer–Lemeshow (HL) goodness-of-fit test. Decision curve analysis (DCA) was performed to evaluate its clinical application.

Results

A total of 494 patients were finally included in the study with a mean age of 70.8 years old. 417 (84.4%) patients were in the survivor group and 77 (15.6%) patients were in the non-survivor group. Multivariate logistic regression analysis based on AIC included age, pO2, neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), invasive mechanical ventilation and vasopressor use to construct the nomogram. The adjusted C-index was 0.745 (0.712, 0.778) with good calibration (HL test, P = 0.147). The Kaplan–Meier survival curves revealed a significantly lower survival probability in the high-risk group than that in the low-risk group (P < 0.001). DCA showed that nomogram was clinically useful.

Conclusion

The nomogram developed in this study could help clinicians to stratify AECOPD patients and provide appropriate care in clinical setting.
Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study
Authors: Chen Jiajia , Zhong Yan , Wei Haiyan , Chen Shaoke , Su Zhe , Liu Lijun , Liang Liyang , Lu Ping , Chen Linqi , Chen Ruimin , Ni Shining , Wang Xinli , Li Li , Wang Yunfeng , Xu Xu , Xiao Yanfeng , Yao Hui , Liu Geli , Jin Runming , Cao Bingyan , Wu Di , Su Chang , Li Wenjing , Qin Miao , Li Xiaoqiao , Luo Xiaoping , Gong Chunxiu
Published: August 2022

Background

To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature.

Methods

This real-world study enrolled children with short stature in 19 hospitals throughout China. They were treated with PEG-rhGH for 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. The primary outcome was the change in height standard deviation score (ΔHt SDS).

Results

Five hundred and ten patients were included and grouped based on dosage as A (0.10–0.14 mg/kg/week), B (0.15–0.16 mg/kg/week), C (0.17–0.19 mg/kg/week), and D (0.20 mg/kg/week). The mean 6-month ΔHt SDS for the total cohort was 0.49 ± 0.27, and the means differed among the four dose groups (P = 0.002). The ΔHt SDS was lower in group A than in groups B (LSM difference [95%CI], -0.09 [-0.17, -0.01]), C (LSM difference [95%CI], -0.10 [-0.18, -0.02]), and D (LSM difference [95%CI], -0.13 [-0.21, -0.05]) after adjusting baseline covariates. There were no significant differences among groups B, C, and D. When the baseline IGF-1 was < -2 SDS or > 0 SDS, the △Ht SDS was not different among the four groups (P = 0.931 and P = 0.400). In children with baseline IGF-1 SDS of -2 ~ 0 SDS, a higher dosage was associated with a better treatment effect (P = 0.003), and the △Ht SDS was lower in older children than in younger ones (P < 0.001).

Conclusions

PEG-rhGH could effectively increase height in prepubertal short children. When the baseline IGF-1 was < -2 SDS, 0.10 mg/kg/week could be a starting dose. In other IGF-1 statuses, 0.15–0.20 mg/kg/week might be preferred.

Trial registration

ClinicalTrials.gov: NCT03249480, retrospectively registered.
Case report: coexistence of primary hyperparathyroidism with giant toxic nodular goiter
Authors: Zhang Wei , Liu Fangyi , Chen Kang , Wang Yajing , Dou Jingtao , Mu Yiming , Lyu Zhaohui , Zang Li
Published: August 2022

Background

The coexistence of primary hyperparathyroidism (PHPT) and giant toxic nodular goiter is very rare. Moreover, PHPT could be easily overlooked because hyperthyroidism may also lead to hypercalcemia. A 99mTc-MIBI scan of the parathyroid glands is often negative when they are concomitant.

Case presentation

Here, we report a rare case of the coexistence of giant toxic nodular goiter and PHPT that had been ignored for many years but was successfully treated with an ultrasound-guided parathyroid adenoma microwave ablation (MWA).

Conclusion

Reoperation for PHPT carries an increased risk of cure failure and complications. Thermal ablation has been proven effective in inactivating hyperfunctioning parathyroid lesions and in normalizing both serum parathyroid hormone (PTH) and calcium.
Digitally prefabricated versus conventionally fabricated implant-supported full-arch provisional prosthesis: a retrospective cohort study
Authors: Chen Chaoqun , Lai Haiyan , Zhu Huiyong , Gu Xinhua
Published: August 2022

Background

To evaluate and compare the clinical outcomes of digitally prefabricated and conventionally fabricated implant-supported full-arch provisional prostheses.

Methods

In this retrospective study, a total of 39 patients (22 males and 17 females) who underwent implant-supported full-arch rehabilitation using the All-on-4 concept with an immediate loading protocol were included: 20 patients treated with digitally prefabricated provisional prostheses were assigned into Group A, and 19 patients treated with conventionally fabricated provisional prostheses were assigned into Group B. Implant/provisional prosthesis survival rates and complications were reviewed. Marginal bone loss (MBL) was investigated by CBCT. Surgical time, restorative time, and total operative time were analyzed. Postoperative pain and swelling were evaluated with the visual analog scale (VAS). The oral health impact profile (OHIP) questionnaire was administered before and after surgery.

Results

The implant/provisional prosthesis survival rate was 100%, and complications appeared with low frequency in both groups, while the mean MBL was 0.30 ± 0.29 mm in Group A and 0.31 ± 0.41 mm in Group B after 3~ 6 months (P > 0.05). The average restorative time in Group A (116.16 ± 16.61 min) was significantly shorter than that in Group B (242.11 ± 30.14 min) (P < 0.05). Patients in Group A showed lower pain/swelling VAS scores after surgery than Group B (P < 0.05). Low OHIP scores with high satisfaction with the overall effects were shown in both groups.

Conclusion

Prefabricated prostheses reduced the prosthetic time and postoperative discomfort in patients whose immediate rehabilitation was based on the All-on-4 concept. This prefabrication technology may be a predictable alternative to improve the short-term clinical outcome of implant-supported full-arch provisional rehabilitation.
Reliability and validity of the Chinese version of the Brief Emotion and Regulation Beliefs Scale in Chinese nursing students
Authors: Zhang Dongmei , Yang Liu , Wang Congzhi , Yuan Ting , Wei Huanhuan , Li Jing , Lei Yunxiao , Sun Lu , Li Xiaoping , Hua Ying , Liu Mingming , Liu Haiyang , Zhang Lin
Published: August 2022

Background

Nursing students are experiencing complex learning environments and will experience complex work environments in future clinical work, which lead to emotional problems easily. However, one’s beliefs about controlling their emotions portend a series of vital psychological outcomes. So, it is especially important to search for suitable tools to assess the emotion and regulation beliefs of nursing students and give timely intervention to improve their physical and mental health. This study aimed to translate the American version of the Emotion and Regulation Beliefs Scale (ERBS) into Chinese, revise the original scale and form a simplified version, and assess the reliability and validity of the brief Chinese version in nursing students.

Methods

The study adopted a cross-sectional design and the multistage sampling design. The ERBS was translated into Chinese, and the reliability and validity of the Chinese version were tested in 980 nursing students.

Results

The content validity index was 0.920. Exploratory factor analysis supported a three-factor model for the Chinese version of Brief-ERBS, and confirmatory factor analysis indicated that the model fit the Brief-ERBS well. Furthermore, the three-factors model was obtained by using exploratory factor analysis, explaining 51.023% variance, and the communalities of the items ranged from 0.359 to 0.680. With modified confirmatory factor analysis, the fit indices were chi-square/degree of freedom (CMIN/DF) = 4.092, goodness of fit index (GFI) = 0.949, adjusted goodness of fit index (AGFI) = 0.927, comparative fit index (CFI) = 0.913, incremental fit index (IFI) = 0.914, Tucker Lewis index (TLI) = 0.908, root-mean-square error of approximation (RMSEA) = 0.061. The two-tailed independent samples t-test showed the scores of the top (50%) and low (50%) groups reached the level of significance (P < 0.001). A highly positive correlation between the Brief-ERBS total score and the ERBS total score was found (r = 0.972, P < 0.01). The Cronbach’s α coefficient of the scale was 0.798, the split-half reliability coefficient was 0.784, and the retest coefficient was 0.879.

Conclusion

The Chinese version of Brief-ERBS has good reliability and validity, and may be used for the beliefs about emotional management in Chinese nursing students.
Risk factors for missed abortion: retrospective analysis of a single institution’s experience
Authors: Jiang Wei-Zhen , Yang Xi-Lin , Luo Jian-Ru
Published: August 2022

Objective

To explore the risk factors including the difference between mean gestational sac diameter and crown-rump length for missed abortion.

Methods

Hospitalized patients with missed abortion and patients with continuing pregnancy to the second trimester from Chengdu Women's and Children's Central Hospital from June 2018 to June 2021 were retrospectively analyzed. The best cut-off value for age and difference between mean gestational sac diameter and crown-rump length (mGSD-CRL) were obtained by x-tile software. Univariate and multivariate logistic regression analysis were adopted to identify the possible risk factors for missed abortion.

Results

Age, gravidity, parity, history of cesarean section, history of recurrent abortion (≥ 3 spontaneous abortions), history of ectopic pregnancy and overweight or obesity (BMI > 24 kg/m2) were related to missed abortion in univariate analysis. However, only age (≥ 30 vs < 30 years: OR = 1.683, 95%CI = 1.017–2.785, P = 0.043, power = 54.4%), BMI (> 24 vs ≤ 24 kg/m2: OR = 2.073, 95%CI = 1.056–4.068, P = 0.034, power = 81.3%) and mGSD-CRL (> 20.0vs ≤ 11.7 mm: OR = 2.960, 95% CI = 1.397–6.273, P = 0.005, power = 98.9%; 11.7 < mGSD-CRL ≤ 20.0vs > 20.0 mm: OR = 0.341, 95%CI = 0.172–0.676, P = 0.002, power = 84.8%) were identified as independent risk factors for missed abortion in multivariate analysis.

Conclusion

Patients with age ≥ 30 years, BMI > 24 kg/m2 or mGSD-CRL > 20 mm had increasing risk for missed abortion, who should be more closely monitored and facilitated with necessary interventions at first trimester or even before conception to reduce the occurrence of missed abortion to have better clinical outcomes.
“Men can take part”: examining men’s role in supporting self-injectable contraception in southern Malawi, a qualitative exploration
Authors: Ruderman Lucy W. , Packer Catherine , Zingani Akuzike , Moses Philemon , Burke Holly M.
Published: August 2022

Background

The male engagement framework for reproductive health, which presents men as family planning users, supportive partners, and agents of change, is being increasingly incorporated into family planning strategies worldwide. We applied this framework to understand the perspectives of and role that men play in supporting the use of self-injection of subcutaneous depot medroxyprogesterone acetate (DMPA-SC).

Methods

We conducted a qualitative analysis using data from a study conducted in southern Malawi to develop and test a counseling message to introduce DMPA-SC and self-injection. We conducted 4 focus group discussions (FGD) with male community leaders and partners of DMPA-SC users, 13 interviews and FGDs with public and private sector family planning providers, and 30 interviews with female clients. We explored all participant groups’ perspectives on what could facilitate or prevent women from choosing self-injection, including views on men’s attitudes towards DMPA-SC and self-injection.

Results

Overall, participants expressed ways that men could be engaged as cooperative users, supportive partners, and agents of change, and felt that this would help build a more supportive environment for DMPA-SC self-injection use. Men held favorable opinions of DMPA-SC self-injection: they felt that it is useful, described ways they could actively and emotionally support their partners in its use, and described their role in normalizing it.

Conclusions

We suggest that DMPA-SC self-injection has the potential to be both a female-controlled and a cooperative method, based on the ability for women to use it autonomously and the option to encourage male partner involvement (only where the woman welcomes this). Shifting the conversation from viewing men as a barrier to men as a resource may allow us to harness the social capital of men and transform traditional power dynamics, therefore establishing more enabling environments to support autonomy and choice for DMPA-SC and self-injection use.
Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
Authors: Su Ping , Zhai Dongxu , Wong Albert H. C. , Liu Fang
Published: August 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19.