bluuebunny/crossref_metadata_2025 huggingface dataset:
Discontinuing Omalizumab Treatment in Super-Responder Patients with Allergic Severe Asthma: Can the Baseline Total IgE Level Be Used as a Biological Marker to Decide Discontinuing Omalizumab Treatment?
Authors: Arslan Bahar , Paçacı Çetin Gülden , Türk Murat , Gülmez İnci , Yılmaz İnsu
Published: August 2022

Background: Although there are many studies presenting the efficacy of omalizumab in severe asthma, the data about the optimal treatment duration are still debated. Objective: In this study, we aimed to investigate the clinical effects of omalizumab discontinuation after 5 years of treatment in patients with omalizumab super-responders, the persistence of response and to compare the features of patients, whose symptoms are still well controlled and those who relapsed and re-treated with omalizumab. Methods: Clinical and laboratory data of 100 adult patients diagnosed with allergic severe asthma and treated with omalizumab between 2008 and 2020 were evaluated retrospectively. Demographic, clinical, functional, and laboratory parameters of the patients who were re-treated with omalizumab and those who did not need to be re-treated were compared. Results: There were 14 super-responder patients, who were treated with omalizumab for 5 years, and the treatment was discontinued then. Omalizumab was not restarted in 9 patients (64%) and was restarted in 5 (36%) patients. No significant difference was presented between these two groups in terms of demographic, clinical, functional, and laboratory parameters. The baseline total IgE levels of patients, who were re-treated with omalizumab, was found to be higher than those who were not, but this difference was not statistically significant (440 [229–864] IU/mL vs. 164 [85–293] IU/mL; p = 0.053, respectively). Conclusion: One of 3 patients was re-treated with omalizumab due to loss of asthma control after discontinuation of the treatment. Therefore, omalizumab’s immunomodulatory effect may seem to persist in a majority of cases after discontinuation. Also, higher baseline total IgE levels might help to predict the cases that need re-treatment after discontinuation.
Enseñar intercomprensión en lenguas germánicas para hispanohablantes: desafíos para el diseño de un curso en línea
Authors: Wilke Valeria , Gentile Patricia de Lauría de
Published: August 2022

Este artículo se propone informar sobre el proyecto de investigación en Intercomprensión en Lenguas Germánicas (ILG) en la Facultad de Lenguas de la Universidad Nacional de Córdoba y explorar los principales desafíos que conlleva la enseñanza en línea de la ILG a hispanohablantes. En el trabajo se presenta el marco teórico subyacente a la intercomprensión en lenguas emparentadas y a la enseñanza en línea. Acá se abordan conceptos como la intercomprensión, el proceso de transferencia y los Siete Cedazos, así como principios de la Educación en Línea (EeL) que se han tenido en cuenta en el diseño de Interger: el viaje. A continuación, se hace referencia a los antecedentes del proyecto de investigación en Europa y Latinoamérica. En cuanto a la metodología, se describen las fases del diseño del curso. En los resultados preliminares, damos cuenta de los principales aspectos del curso, haciendo especial hincapié en los desafíos que conlleva este trabajo.
Ungleichheit differenziert begegnen: Vorschläge für binnendifferenzierten Schreibunterricht online und auf Distanz
Authors: Eckrich Leonie Helen , Pereira Rogéria Costa
Published: August 2022

Die Corona-Pandemie hat den Präsenzunterricht vielerorts unmöglich gemacht und Lehrende und Lernende dazu bewegt, neue Möglichkeiten für einen Unterricht im Online-Format zu erkunden. Die Heterogenität der Lernenden an den Kursen der Casa de Cultura Alemã der Universidade Federal do Ceará (CCA) und der ab August 2020 durchgeführte Onlineunterricht haben uns zudem dazu bewegt, neue Unterrichtsverfahren zu ermitteln. Wir konnten feststellen, dass die schon vor der Pandemie große Heterogenität in den Deutschkursen der CCA in der Pandemie durch das neue Unterrichtssetting noch größer wurde, einerseits durch ein erhöhtes Maß an Selbstorganisation und aufzubringende -motivation, und andererseits durch die technischen Gegebenheiten der einzelnen Teilnehmer*innen. Um dieser Heterogenität gerecht zu werden, stellten wir uns die Frage, wie sich binnendifferenzierende Maßnahmen im Onlineunterricht, gestützt durch Online-Tools, umsetzen lassen. Besonders große Unterschiede finden sich im Hinblick auf die Schreibkompetenz der Teilnehmer*innen. Im vorliegenden Beitrag werden daher binnendifferenzierende Maßnahmen für das Training der Fertigkeit Schreiben im Online-Format vorgestellt.
Ensino remoto de fonética e fonologia da língua alemã: algumas experiências práticas no contexto universitário durante a pandemia
Authors: Romão Tito Lívio Cruz , Nogueira Francisco Gleiberson dos Santos
Published: August 2022

O objetivo deste artigo é descrever o andamento dos trabalhos de ensino remoto realizados no âmbito da disciplina de Fonética e Fonologia da Língua Alemã, ministrada no Curso de Letras Português – Alemão da Universidade Federal do Ceará, como componente obrigatória de ensino. Nossa fundamentação teórica pauta-se em autores das áreas de Fonética e Fonologia da Língua Alemã (Dieling; Hirschfeld, 1995; Mangold, 2015), de Fonética Contrastiva (Langer, 2004), de Ensino de Alemão como Língua Estrangeira (Bausch; Christ; Hüllen; Krumm, 1991), bem como no Quadro Europeu Comum de Referência para Línguas (Conselho da Europa, 2001; Klett 2020). Mediante a descrição de algumas tarefas realizadas na sala de aula remota, apresentamos a trajetória da disciplina objeto deste artigo durante os dois anos de pandemia compreendidos entre 2020 e 2022. Nossos resultados apontam para os desafios enfrentados por docentes e discentes envolvidos, mas também para relatos em que se destacam, por um lado, experiências exitosas e, por outro, situações-limite em que o ensino presencial teria sido preferencial.
Formação inicial de professoras/es de línguas e contexto pandêmico: o foco nas práticas colaborativas para o enfrentamento de desafios
Authors: Stanke Roberta Cristina Sol Fernandes , Ferreira Mergenfel Vaz
Published: August 2022

Os desafios na formação inicial de docentes são inúmeros, especialmente de professores de línguas adicionais. No contexto pandêmico do novo Coronavírus, mais desafios foram impostos, especialmente no emprego quase que imediato de tecnologias digitais para uma modalidade de ensino emergencial remota. No artigo em tela, discutimos os desafios que foram impostos à formação inicial de professores de alemão como língua adicional, considerando a crise pandêmica e o contexto de projetos de extensão em duas universidades públicas do Rio de Janeiro. Como fundamentação teórica baseamo-nos nos conceitos de professor reflexivo e prática reflexiva, bem como de teorias sociointeracionistas para a discussão de práticas colaborativas na formação de professores. Adotamos como metodologia de pesquisa uma abordagem interpretativista, calcada na observação-participante e na pesquisa-ação, com dados gerados a partir de análise de diários e documentos oriundos dos encontros de orientação entre as/os extensionistas e as professoras orientadoras. Os resultados deste estudo apontam a importância das práticas colaborativas adotadas nos encontros de orientação acadêmica no âmbito de projetos de ensino-aprendizagem de línguas, as quais se atrelam à formação de um profissional reflexivo, que através da reflexão e da ação são agentes de transformações socioeducacionais.
Ensino remoto em tempos de pandemia: uma experiência de formação emergencial e seus desdobramentos
Authors: Bolacio Filho Ebal Sant’Anna , Schumann Carina , Savedra Mônica Maria Guimarães
Published: August 2022

O presente artigo tem por objetivo descrever uma ação de formação emergencial que teve lugar em julho de 2020 no âmbito da formação de professores de alemão como língua estrangeira (ALE) nos projetos de extensão de três universidades públicas do estado do Rio de Janeiro. O projeto foi proposto e desenvolvido por professores-formadores das três universidades e teve a participação de graduandos das três instituições que atuavam nos cursos livres ofertados pelas instituições. O intuito do curso era fornecer reflexões teóricas e uma introdução prática ao trabalho online que se impunha então como única alternativa viável. Serão apresentados a estrutura do curso e os conteúdos trabalhados durante as três semanas de duração da formação. Além disso, serão discutidos igualmente os resultados das avaliações feitas pelos participantes do curso logo após o término e um ano após, a fim de se averiguar o papel que o curso possa ter tido na prática daqueles que participaram da formação.
Die Zirkulation und Rezeption der historischen Romane von Carl Franz van der Velde im 19. Jahrhundert
Authors: Assumpção Larissa de
Published: August 2022

Ziel dieser Arbeit ist es, die Verbreitung und Rezeption der historischen Romane des deutschsprachigen Autors Carl Franz van der Velde (1779-1824) zu analysieren, um Hinweise darauf zu finden, wo diese Bücher zirkulierten und wie sie von einigen deutschen Literaturkritikern im neunzehnten Jahrhundert gelesen wurden, um auf diese Weise einen Beitrag zu den Studien über die Geschichte des Buches und des Lesens zu leisten. Das Korpus der Untersuchung besteht aus Auswertungen von Bibliothekskatalogen weltweit, aus den Bewertungen der Kritiker, die in zwei deutschen Literaturzeitschriften – der Leipziger Literaturzeitung (1800-1833) und der Jenaische Allgemeinen Literaturzeitung (1804-1841) ­– veröffentlicht wurden, und aus den brasilianischen Bibliothekskatalogen und Zeitungsanzeigen, die auf der Website der Brasilianischen Nationalbibliothek verfügbar sind. In der Analyse werden drei Hauptaspekte betrachtet: wie viele Ausgaben und Übersetzungen van der Veldes Romane im 19. Jahrhundert erlebten, welche Kriterien zur Bewertung seiner Bücher verwendet wurden und wie ihre Verbreitung in Brasilien war. Die Analyse zeigt, dass van der Veldes Werke in verschiedenen Ländern weit verbreitet waren und in den literarischen Zeitungen meist positiv bewertet wurden, was Informationen über die Relevanz und Verbreitung des deutschsprachigen historischen Romans, insbesondere in der ersten Hälfte des neunzehnten Jahrhunderts, liefern kann.
Literatura e escrita criativa em sala de aula invertida de alemão como língua estrangeira durante a pandemia de Covid-19
Authors: Lima Adriana Borgerth V. C.
Published: August 2022

Durante a pandemia de Covid-19 em 2020, professores e alunos viram-se impelidos a utilizar estratégias de ensino remoto, para não interromperem o andamento das aulas. Nesse contexto, o modelo pedagógico “Sala de Aula Invertida” (Leffa; Duarte; Alda 2016) (Andrade; Coutinho 2018) foi uma possibilidade para a implementação on-line da proposta “Literatura e escrita criativa em sala de aula invertida de alemão como língua estrangeira”. A literatura pode se apresentar como alternativa a textos não-autênticos dos livros didáticos de língua estrangeira, trazendo importantes contextos de vocabulário e estruturas corretamente empregadas (Koppensteiner 2001). A escrita criativa tem na leitura a base que constrói o repertório do escritor, e, através de técnicas, resgata sua criatividade (Rodrigues 2015). O professor de língua estrangeira poderá usar essa criatividade para trabalhar em aula a escrita, além da gramática, da leitura, da oralidade (Silva 2013). Da proposta participaram uma dupla e uma aluna individual, de nível A2 (QECR 2001); foram lidos cinco livros de autores de língua alemã, discutidos os temas abordados nas obras, contextualizados e também transpostos para os dias atuais, permitindo às alunas comentá-los no contexto cultural brasileiro. Esse processo embasou a escrita das histórias dessas alunas.
Atividades didáticas de ensino de alemão em contexto remoto emergencial: análise do poder e propostas de ação para a reflexão crítica
Authors: Arantes Poliana Coeli Costa , Caspary Rayanne Lira Favacho
Published: August 2022

O presente artigo tem como objetivo apresentar uma cartografia das relações de poder na perspectiva foucaultiana envolvidas no contexto de ensino e aprendizagem de Alemão como Língua Estrangeira (ALE), aprofundando-a ao levar em consideração os impactos da pandemia de Covid-19. Nesse sentido, propomos uma reflexão a respeito do uso de materiais criados para a modalidade de aulas presenciais e os desafios para docentes e discentes na adaptação do mesmo para o uso nas aulas remotas (Rocha, Deusdará, Arantes, 2020). Para tal, desenvolvemos uma análise de atividades selecionadas de livros didáticos largamente utilizados em cursos de alemão no Brasil e, a partir dessa análise, apresentaremos nossas propostas de adaptação desses materiais a fim de fomentar a criticidade utilizando-se o referencial da Análise do Discurso e do poder (Foucault, [1979], 2003).
A concepção de arte de Mário de Andrade, no 'Rito do irmão pequeno': uma leitura à luz de Schiller e do trecho suprimido de "Amar, verbo intransitivo"
Authors: Souza Cristiane Rodrigues de
Published: August 2022

Por meio da poesia de Mário de Andrade, pode-se apreender a concepção do modernista acerca do fazer artístico, principalmente em seus poemas amorosos. No grupo “Rito do irmão pequeno” (1931), em que se estabelece uma ligação de amizade e de amor entre o eu lírico e o irmão, são encenadas questões que tocam o tema da arte. Dessa forma, o estudo dos versos de 1931, levando em consideração afirmações de Friedrich Schiller, assim como as reflexões teóricas presentes nos trechos suprimidos por Mário, no exemplar de trabalho de Amar, verbo intransitivo, leva-nos a compreender a concepção artística de Mário de Andrade.
Processos de criação da canção na Belle Époque carioca e alguns apontamentos sobre o Modernismo
Authors: Rentroia Celio
Published: August 2022

O presente artigo investiga os processos de criação e performance da canção na Belle Époque carioca, observando os trânsitos entre teatro musicado e música popular. A partir desse foco, são examinados alguns princípios modernistas que impactaram a compreensão da arte brasileira, e cujos reflexos se estendem até a atualidade. A metodologia dialoga com a teoria crítica de processos de criação de Cecilia Salles e com os estudos sobre performance de Ruth Finnegan e Paul Zumthor. Foram analisados estudos críticos, partituras, e fontes históricas e biográficas.
Alceu Amoroso Lima: a conversão católica do “crítico do modernismo”
Authors: Serrano Pedro Bueno de Melo
Published: August 2022

Este artigo se propõe a analisar o percurso da conversão de Alceu Amoroso Lima (Tristão de Athayde) em direção à militância católica, observando as repercussões disso em sua atividade de crítico literário e, particularmente, em sua relação com o modernismo e os expoentes paulistas da Semana de Arte Moderna de 1922. Para isso, interpreto três materiais: a correspondência entre Alceu Amoroso Lima e Jackson de Figueiredo, considerando se tratar de um “arquivo da conversão” do crítico carioca ao catolicismo; as biografias e trajetórias desses dois intelectuais; e artigos jornalísticos (ou “rodapés”, como também eram denominados) de Tristão de Athayde, reveladores de suas avaliações sobre o modernismo, antes e depois da viragem à religião católica.
Advanced Techniques for Ethanol Ablation of Left Ventricular Summit Region Arrhythmias
Authors: Patel Apoor , Nsahlai Michelle , Flautt Thomas , Da-Warikobo Akanibo , Lador Adi , Tapias Carlos , Rodríguez Diego , Carlos Sáenz Luis , Schurmann Paul A. , Dave Amish , Valderrábano Miguel
Published: August 2022

Background:

Coronary venous ethanol ablation (VEA) can be used as a strategy to treat ventricular arrhythmias arising from the left ventricular summit, but collateral flow and technical challenges cannulating intramural veins in complex venous anatomies can limit its use. Advanced techniques for VEA can capitalize on collateral vessels between target and nontarget sites to improve success.

Methods:

Of 55 patients with left ventricular summit ventricular arrhythmia, advanced techniques were used in 15 after initial left ventricular summit intramural vein mapping failed to show suitable targets for single vein, single-balloon VEA. All patients had previous radiofrequency ablation attempts. Techniques included: double-balloon for distal protection to block distal flow and target the proximal portion of a large intramural vein where best signal was proximal (n=6); balloons in 2 different left ventricular summit veins for a cross-fire multivein VEA (n=4); intramural collateral vein-to-vein cannulation to reach of targeted vein via collateral with antegrade ethanol and proximal balloon block (n=2); prolonged ethanol dwell time for vein sclerosis of large intramural vein and subsequent VEA (n=3); and intramural collateral VEA (n=1).

Results:

Fifteen (8 females) patients (age 60.6±17.6 years) required advanced techniques. Procedure time was 210±49.9 minutes, fluoroscopy time was 25.3±14.1 minutes, and 113±17.9 cc of contrast was utilized. A median of 7 cc of ethanol was delivered (range, 4–15 cc). Intraprocedural radiofrequency ablation was delivered before ethanol in 9 out of 15 patients but failed. Ethanol achieved acute success in all 15 patients. Ethanol was used as the sole treatment in two patients. At a median follow-up of 194 days, one patient experienced recurrence.

Conclusions:

Advanced techniques capitalizing on venous anatomy can enable successful VEA and selective targeting of arrhythmogenic sites, by blocking distal flow, utilization of collaterals between nontarget and target veins and multivein VEA. Understanding individual anatomy is critical for VEA success.
Religion und Resonanz
Authors: Gärtner Stefan
Published: August 2022

This article examines the religious functions of the Dutch performance practice of Johann Sebastian Bach’s St. Matthew Passion. It introduces the phenomenon itself, points out its religious and ritual significance in the post secular Netherlands, and interprets the passion play with Hartmut Rosa’s social theory. A conclusion about resonance as the common third between religious and aesthetic experiences rounds off the study.
Zur Ambiguität von Religion und Politik in Deutschland: die Evangelische Kirche in der NS-Zeit
Authors: Becker Frank
Published: August 2022

During the Nazi era, the Protestant Church in Germany was challenged by the so-called church struggle between the German Christian Movement and the Confessing Church. This article interprets the church struggle in a new way by taking up concepts from Niklas Luhmann’s Systems Theory and ambiguity research. It becomes clear that the church struggle was ultimately about the fundamental problem of the relationship between the religious and political system.
Interpreting Pauline Paradox: A Response to Gorman’s Cruciformity Concept
Authors: White B.G.
Published: August 2022

Michael Gorman’s ‘cruciformity’ concept (recently re-articulated as ‘resurrectional cruciformity’) is commonly used to interpret Paul’s paradox of strength in weakness (e.g., 2 Cor. 4:7, 12:9–10). However, Gorman never discusses the current conceptions of Pauline paradox. An analysis and summary of this literature – with reference to 2 Cor. 12:9–10 – reveals that Gorman’s approach fails to produce a technical articulation of paradox, largely due to its underdeveloped congruence between strength and weakness (cf., v. 9a, 10b). This leaves his work vulnerable to theological distortion, including masochism. In response, it is argued that ‘strength in weakness’ involves two opposed realities occurring simultaneously and mutually qualifying one another, without conflation or isolation – i.e., a coinherent paradox. This model offers a generative, rather than kenotic, reading of strength in weakness, in which the paradox increases human potential. It also offers connections with early Christology that set the paradox in a fresh theological frame.
Encountering Bultmann as a Biblical Theologian
Authors: Blaylock Richard M.
Published: August 2022

In this paper, I seek to provide insight into Rudolf Bultmann’s work by engaging with it through the lenses of biblical theology. To do so, I first describe the presuppositions behind Bultmann’s approach to biblical theology by discussing three polarities crucial to his thinking: (1) mythology versus science, (2) Historie versus Geschichte, and (3) objective knowledge versus revelation. I then explore Bultmann’s exegetical methods under three headings: (1) historical-critical methods, (2) demythologizing, and (3) existentialist interpretation. Lastly, I locate Bultmann within the field of biblical theology by concluding that he was a theologian who (1) rejected the unity of the Scriptures in favor of their diversity, (2) bridged the gap between history and theology through prioritizing Geschichte over Historie, (3) included extra-canonical materials within the scope of biblical theology, and (4) viewed the kerygma as normative in an existentialist fashion.
Intertextuality and Hermeneutic Phenomenology: Finding Hermeneutical Clarity in the Diversity of New Testament Scholarship
Authors: Smith Dain Alexander
Published: August 2022

The field of intertextuality in biblical and theological scholarship is theoretically complex and diverse. The prevailing differences among intertextual interpreters produce this question: is there a hermeneutical theory that can clarify the diverse field of intertextuality? In order to answer this question, this essay interacts with hermeneutic phenomenology to demonstrate a common hermeneutical thread that clarifies the diversity of intertextual analysis. First, I delineate the foundations of intertextual theory in order to demonstrate how those foundations lead interpreters in a specific hermeneutical direction. Second, I explain how an intertextual analysis is complemented by Hans-Georg Gadamer and Paul Ricoeur’s contributions to hermeneutics. Third, I demonstrate that Ricoeur’s comments on intertextuality challenge intertextual interpreters to move from intertextual theory into hermeneutical practice. Fourth, I propose that Ricoeur’s three-layered mimesis clarifies the diversity of intertextual analysis. Finally, I conclude by suggesting hermeneutical guidelines for intertextual interpreters in biblical and theological studies.
Analyses of morphological and molecular characteristics of Telotylenchinae from Iran point at the validity of the genera Bitylenchus and Sauertylenchus
Authors: AZIZI KOUROSH , ESKANDARI ALI , KAREGAR AKBAR , GHADERI REZA , ELSEN SVEN VAN DEN , HOLTERMAN MARTIJN , HELDER JOHANNES
Published: August 2022

To investigate relationships within the subfamily Telotylenchinae, more than 500 soil samples were collected from various natural and agricultural habitats in several localities of Iran. Individuals of seven known species, including Bitylenchus dubius, B. parvus, B. serranus, Sauertylenchus maximus, Tylenchorhynchus clarus, T. microconus and Trophurus ussuriensis, were recovered and characterized based on morphological and morphometric characters. Furthermore, phylogenetic relationships within representatives of the subfamily Telotylenchinae were explored using 13 sequences from the D2-D3 expansion regions of 28S ribosomal (r) DNA and 13 sequences for the partial 18S rDNA genes obtained in the present study. Analyses based on the relatively conserved 18S rDNA gene underlined the polyphyletic status of Tylenchorhynchus sensu lato, as three clusters representing Tylenchorhynchus, Bitylenchus and Sauertylenchus were well separated, and interspersed by, e.g., representatives of the Macrotrophurinae. Analysis of the more variable D2-D3 28S rDNA sequences suggested at least four clades within the subfamily Telotylenchinae: two clades dominated by Tylenchorhynchus species; a third clade harbouring representatives of Sauertylenchus, Bitylenchus, and Paratrophurus in distinct but unresolved branches;and a fourth clade dominated by Trophurus species. Although no molecular information was available from a number of genera that were originally gathered under Tylenchorhynchus sensu lato, we concluded that both Bitylenchus and Sauertylenchus should be seen as valid Telotylenchinae genera related to, but distinct from Tylenchorhynchus.
Dependence of Ice Crystal Size Distributions in High Ice Water Content Conditions on Environmental Conditions: Results from the HAIC-HIWC Cayenne Campaign
Authors: Hu Yachao , McFarquhar Greg M. , Brechner Peter , Wu Wei , Huang Yongjie , Korolev Alexei , Protat Alain , Nguyen Cuong , Wolde Mengistu , Schwarzenboeck Alfons , Rauber Robert M. , Wang Hongqing
Published: August 2022

A new method that automatically determines the modality of an observed particle size distribution (PSD) and the representation of each mode as a gamma function was used to characterize data obtained during the High Altitude Ice Crystals and High Ice Water Content (HAIC-HIWC) project based out of Cayenne, French Guiana, in 2015. PSDs measured by a 2D stereo probe and a precipitation imaging probe for particles with maximum dimension (Dmax) > 55 μm were used to show how the gamma parameters varied with environmental conditions, including temperature (T) and convective properties such as cloud type, mesoscale convective system (MCS) age, distance away from the nearest convective peak, and underlying surface characteristics. Four kinds of modality PSDs were observed: unimodal PSDs and three types of multimodal PSDs (Bimodal1 with breakpoints 100 ± 20 μm between modes, Bimodal2 with breakpoints 1000 ± 300 μm, and Trimodal PSDs with two breakpoints). The T and ice water content (IWC) are the most important factors influencing the modality of PSDs, with the frequency of multimodal PSDs increasing with increasing T and IWC. An ellipsoid of equally plausible solutions in (No–λ–μ) phase space is defined for each mode of the observed PSDs for different environmental conditions. The percentage overlap between ellipsoids was used to quantify the differences between overlapping ellipsoids for varying conditions. The volumes of the ellipsoid decrease with increasing IWC for most cases, and (No–λ–μ) vary with environmental conditions related to distribution of IWC. HIWC regions are dominated by small irregular ice crystals and columns. The parameters (No–λ–μ) in each mode exhibit mutual dependence.
Typhoon Forecasts with Dynamic Vortex Initialization Using an Unstructured Mesh Global Model
Authors: Huang Ching-Yuang , Lin Jia-Yang , Skamarock William C. , Chen Shu-Ya
Published: August 2022

A dynamical vortex initialization (DVI) scheme is implemented on unstructured meshes for the global model MPAS for typhoon forecasts. The DVI extracts the departure vortex within a specified radius of the vortex center and implants this vortex at the observed vortex location in continuously cycled 1-h integrations of the model. The cycling integration is stopped when either the simulated central sea level pressure or maximum wind speed of the typhoon has reached the value in the best track data, denoted as P-match or V-match, respectively. The DVI may spin up the initial vortex with a more contracting eyewall, but still keeping the same size of the outer vortex. Forecasts for 16 typhoons over the western North Pacific in 2015–20 are investigated. Predictions from the experiments with the 60–15-km variable-resolution MPAS mesh show that both P-match and V-match significantly improve the track forecasts, where V-match mostly requires less cycle runs than P-match. Cycling results with P-match or V-match are also dependent on the choice of physics suites within MPAS. Positive impacts are larger for V-match than P-match using the mesoscale reference physics suite, with significantly improved track forecasts and earlier intensity forecasts. Intensity differences resulting from the DVI have gradually decreased with forecast time, which are closely correlated to the differences in the averaged tropospheric potential vorticity of the inner vortex. The DVI with the 60–15–3-km variable-resolution mesh also works well and improves intensity forecasts. The DVI can also help produce asymmetric structures and spin up inner vortex cores for typhoons near high topography, which leads to improved intensity forecasts.
Pharyngesophageal Diverticula Following Anterior Cervical Discectomy and Fusion
Authors: Beesley Hassan , Piraquive Jacquelyn , Jaleel Zaroug , Tracy Lauren F
Published: August 2022

Objectives:

Development of traction pharyngesophageal diverticula following anterior cervical discectomy and fusion (ACDF) is a rare but morbid cause of dysphagia and the optimal surgical management is unclear.

Methods:

PubMed, GoogleScholar, Embase database reviews of “traction diverticula/um + anterior cervical/ACDF.” Patient demographics, presenting symptoms, surgical technique, and outcomes were compared.

Results:

Seventeen manuscripts reported 21 cases of pharyngesophageal diverticulum (PED) following ACDF (10 F:11 M, mean age 45 years). Presenting symptoms included dysphagia (n = 18), regurgitation (n = 10), and weight loss (n = 6). The average interval to presentation was 4.5 years after ACDF (range: 6 months-18 years) and ACDF levels most commonly involved were C5-C6 and/or C6-C7 (n = 12). Open diverticulectomy with (n = 12) and without (n = 6) cricopharyngeal myotomy was the most common approach and reinforcement with vascularized tissue was used in 6 patients (29%). Attempted endoscopic diverticula repair was successful in 1 patient, was converted to open repair in 5 patients, and 1 patient did not have surgical repair. ACDF hardware was removed in 11 cases (52%) and was routinely removed when concomitant infection was present. Complications following repair were reported in 6 patients (30%).

Conclusion:

Traction pharyngesophageal diverticula are a rare cause of dysphagia which occur after a variable interval following ACDF. Open surgical diverticulectomy yields superior outcomes compared to the endoscopic approach. In the setting of infection hardware removal is recommended. Vascularized tissue reinforcement can limit potential esophageal leak; however, the risk of post-operative complications remains high.
Rome and the total solar eclipse of BC188 July 17: Apology
Authors: Morrison L.V. , Stephenson F.R. , Hohenkerk C.Y.
Published: August 2022

An apology for a missed reference.
Retroperitoneal lymph-node dissection (RPLND) as upfront management in stage II germ-cell tumours: Evaluation of safety and efficacy
Authors: Nicolai Nicola , Nazzani Sebastiano , Tesone Antonio , Macchi Alberto , Piva Luigi , Salvioni Roberto , Stagni Silvia , Torelli Tullio , Agostini Edoardo , Celso Francesco , Giannatempo Patrizia , Procopio Giuseppe , Avuzzi Barbara , Lanocita Rodolfo , Cattaneo Laura , Catanzaro Mario , Biasoni Davide
Published: August 2022

Introduction:

Patients with stage II germ-cell tumours (GCT) usually undergo radiotherapy (seminoma only) or chemotherapy. Both strategies display a recognised risk of long-term side effects. We evaluated retroperitoneal lymph node dissection (RPLND) as exclusive treatment in stage II GCT.

Methods:

Between 2008 and 2019 included, 66 selected stage II GCT patients underwent primary open (O-) or laparoscopic (L-)RPLND. Type of procedure and extent of dissection, operative time, node rescue, hospital stay, complications (according to Clavien-Dindo), administration of chemotherapy, relapse and site of relapse were evaluated.

Results:

Five patients had pure testicular seminoma. Nineteen (28.8%) had raised markers prior to RPLND; 48 (72.7%), 16 (24.2%) and two (3.0%) were stage IIA, IIB and IIC, respectively. O-RPLND and unilateral L-RPLND were 36 and 30 respectively. Six stage II A patients (12.5%) had negative nodes. Four patients underwent immediate adjuvant chemotherapy. One patient was lost at follow-up. After a median follow-up of 29 months, 48 (77.4%) of the 62 patients undergoing RPLND alone remained recurrence-free; one patient had an in-field recurrence following a bilateral dissection. According to procedure, number of rescued nodes (O-RPLND: 25. IQR 21-31; L-RPLND: 20, IQR 15-26; p: 0.001), hospital stay (L-RPLND: 3 days, IQR 3-4; O-RPLND: 6 days, IQR 5-8; p: .001) and grade ≥2 complications (L-RPLND 7%, O-RPLND 22%; p: 0.1) were the only significant differences.

Conclusion:

Primary RPLND is safe in stage II GCT, including seminoma, and may warrant a cure rate greater than 70%. When feasible, L-RPLND may be as effective as O-RPLND with better tolerability.
Evaluating Driver Response to a Dynamic Speed Feedback Sign at Rural Highway Curves
Authors: Mahmud Md Shakir , Bamney Anshu , Megat Johari Megat Usamah , Jashami Hisham , Gates Timothy J. , Savolainen Peter Tarmo
Published: August 2022

Research was performed to assess the effectiveness of a dynamic speed feedback sign (DSFS) as a speed reduction countermeasure when installed at horizontal curves on rural highways. It was of particular interest to assess whether the DSFS effectiveness varied based on curve advisory speed and to identify the optimal DSFS placement location with respect to the curve. A series of field evaluations were performed at five horizontal curves located along two-lane rural state highways in northern Michigan possessing posted speed limits of 65 mph and curve advisory speeds varying between 25 and 60 mph. The DSFSs were installed and evaluated at two different locations at each curve: 1. at the curve advance warning/advisory speed sign and 2. at the point of curvature. Vehicle speeds were tracked along the approach to each curve using handheld LIDAR guns. The results indicate that the DSFS was generally more effective at reducing motorists’ speeds when installed near the advance curve warning sign. Furthermore, the DSFS was more effective at locations with sharper curvature (i.e., lower advisory speeds). Continued use of DSFSs as a speed reduction countermeasure on rural horizontal curves is recommended, particularly at locations with a significant differential (e.g., at least 25 mph) between the upstream speed limit and the curve advisory speed. The DSFS should be positioned near the advance curve warning/advisory speed sign to provide adequate time for drivers to react and decelerate before reaching the curve.
Thermographic Examination of the Gingiva of 16 Dogs
Authors: Yiğitarslan Kürs¸ad , Özcan Candemir , Cetintav Bekir
Published: August 2022

Gingivitis is a common periodontal disease in dogs and refers to inflammation of the gingiva. Gingival Index (GI), Papillary Bleeding Index (PBI) and Plaque Index (PI) are oral indices that describe the health status of the gingiva and which are based on human observation. Thermal changes due to inflammation are expected in gingivitis. Thermographic imaging, a wide-spread diagnostic tool in veterinary science, can be used for identification when there is abnormal body surface temperature in an area of the animal body. In this study, oral examination results and thermographic images obtained from 458 teeth from 16 dogs were used. Firstly, a thermal imaging procedure for diagnosis of gingival diseases of dogs was defined. Secondly, reference surface temperatures of tissues for each oral indices were determined. And thirdly, statistically significant thermal differences between the levels of each index was compared. The statistical analysis showed that there are significant thermal differences in some index levels and that presence or absence of plaque is an important etiologic factor in thermal examination of gingivitis. The study showed that thermographic images can be used to determine thermal changes in oral tissues of dogs with gingivitis.
Multi-objective design optimization of a Turret’s U-bracket mounted on moving platform
Authors: Anguek Oussama , Bounab Belkacem
Published: August 2022

This paper aims to model and design a lightweight U-bracket for two degrees of freedom (DOF) mechanism used to carry a machine gun. The mechanism is called a weapon station or a gun turret and can be mounted on any mobile platform. Due to the movement of the platform and the gun recoil force, the gun turret is subjected to high disturbances. So, to get better performances in terms of distributed efforts, stability and precision, the mechanism has to be optimally designed. The trunnion axis offset corresponding to higher dynamic and structural performance was determined based on probabilistic analysis and finite element simulations. Then, the co-simulation between MATLAB and ANSYS Parametric Design Language (APDL) was performed to get the optimal shape of the U-bracket by minimizing its mass, and maximizing its first natural frequency subjected to maximum stress constraint. To solve this constrained optimization problem, the Multi-Objective Genetic Algorithm (MOGA) technique was used. Through numerical simulations, the proposed approach shows the ability to provide a generic methodology to design the U-bracket of a 2-DOF weapon station efficiently.
Tele-assessment of core performance and functional capacity: Reliability, validity, and feasibility in healthy individuals
Authors: Güngör Feray , Ovacık Uğur , Ertan Harputlu Özge , Yekdaneh Ayşe Asena , Kurt İrem , Ertürk Uzunoğlu Gamze , Polat İlgüz Başak , Aküzüm Funda , Akbaba Yıldız Analay
Published: August 2022

Introduction

Many assessment methods are used in physiotherapy to analyze the fitness level and injury risk in athletes, and to determine the general health status and the effectiveness of the treatment applied in patients. Considering the need for telehealth use, it is essential to determine the usability of tests performed as tele-assessment. This study aimed to examine the intra-rater reliability, validity, and feasibility of the tele-assessment version of core strength and endurance and functional capacity assessments in healthy individuals.

Methods

“Curl-up,” “Modified Push-up,” “Plank,” and “Lateral Bridge” tests were used for core strength and endurance performance assessment, and “Timed Up and Go,” “30 second Sit to Stand,” and “Functional Reach Test” tests were used for functional capacity assessment in healthy individuals. Participants were evaluated first by tele-assessment, then one hour later on the same day, all assessments were repeated face-to-face procedures by the researchers thus the validity of the tele-assessment method was determined. All tests were applied as tele-assessment one week later to determine the intra-rater reliability of the tele-assessment method. The system usability scale was applied to evaluate the usability of our tele-assessment method.

Results

Eighty healthy people were enrolled. Intraclass correlation coefficients ranged between 0.91 and 0.97 for core performance tests and between 0.95 and 0.97 for functional tests. All tele-assessment versions of the core performance and functional tests were highly correlated with the face-to-face versions.

Discussion

Core strength-endurance and functional tests performed via tele-assessment were reliable, valid, and feasible for practically measuring the performance of healthy young adults. This study supports the tele-assessment versions of these tests.

Trial registration number and trial register

Clinicaltrials.gov: NCT04899804
Comparative wear behaviour of Ni-Cr-B-Si hardface coatings made by cold metal transfer and plasma transfer Arc welding processes
Authors: Mishra Rismaya Kumar , Kumar Hemant , Harmain GA , Albert Shaju K
Published: August 2022

Ni-Cr-B-Si hardface coating plays an important role in the mating components of nuclear power plants. Obtaining a crack-free coating with low dilution and optimum hardness is essential for reactor applications. In general, it is difficult to achieve this through conventional high heat input processes. In this work, Ni-Cr-B-Si hardface coating was successfully developed on 316LN stainless steel substrate by Cold Metal Transfer (CMT) welding process using metal-cored filler wire. Moreover, for comparative analysis, Ni-Cr-B-Si hardface coating was deposited using Plasma Transferred Arc (PTA) process. The obtained coatings were characterised for their microstructure, hardness, and wear behaviour. Results revealed higher hardness and lower specific wear rate of hardface coating made by the CMT process compared to the coating made by the PTA process. The superior behaviour of the CMT coating obtained may be due to its low dilution compared to the coating made using the PTA process. Confocal microscopy on the worn pins revealed abrasive and adhesive wear as a dominant mechanism in the CMT and PTA coatings, respectively. This study concluded that CMT could be used as an alternate potential process for depositing a crack-free hardface coating with superior wear behaviour.
Health-related quality of life outcomes in adolescent Scheuermann’s kyphosis patients treated with posterior spinal fusion: A comparison with age- and sex-matched controls
Authors: Suominen Eetu N , Saarinen Antti J , Syvänen Johanna , Diarbakerli Elias , Helenius Linda , Gerdhem Paul , Helenius Ilkka
Published: August 2022

Purpose:

To assess the health-related quality of life and radiographic outcomes of surgically treated adolescent Scheuermann’s kyphosis patients after minimum of 2-year follow-up and to compare the health-related quality of life with age- and sex-matched healthy controls.

Methods:

Twenty-two consecutive adolescents (mean age = 16.7 years) undergoing posterior spinal fusion for Scheuermann’s kyphosis were included and matched by age and sex with two healthy controls. The health-related quality of life was evaluated using the Scoliosis Research Society-24 questionnaire. Radiographic parameters were measured for comparison preoperatively and at 6 months and 2-year follow-ups. The health-related quality of life parameters were compared with healthy controls at 2 years of follow-up.

Results:

The mean maximal thoracic kyphosis improved from 79° (range = 75°–90°) to 55° (range = 45°–75°) ( p < 0.001), and the mean lumbar lordosis was reduced from 71° (range = 51°–107°) to 52° (range = 34°–68°) ( p < 0.001) after 2 years postoperatively. Incidence of proximal junctional kyphosis (PJK) was 18%. The scores of the Scoliosis Research Society-24 improved, with statistical significance observed in pain and self-image domains from preoperative to 2-year follow-up ( p = 0.002 in both domains). The self-image and function were significantly lower in the operated patients at their 2-year follow-up visit compared to controls ( p = 0.023 for self-image and p < 0.001 for function).

Conclusion:

Instrumented posterior spinal fusion improves the health-related quality of life of Scheuermann’s kyphosis patients during the 2-year follow-up. The greatest improvement is observed in pain and self-image domains. The health-related quality of life in pain and activity domains reaches the level of healthy individuals, while function and self-image remain at a statistically lower level.
Pediatric phalanx fractures: A retrospective study and review of the literature
Authors: Schizas Stephanie , Lutz Nicolas , Vardar Elif , Merckaert Sophie , Zambelli Pierre-Yves , Samara Eleftheria
Published: August 2022

Purpose:

Conventional radiography is frequently performed in pediatric patients in whom finger fractures are suspected. However, until now, the rate of positive findings of finger radiographic examinations in pediatric patients is unknown. This study aimed to evaluate the number of positive findings in the standard radiographic examinations of finger injuries in pediatric patients in a Level 1 trauma center systematically.

Methods:

We conducted a retrospective study on all children 0–16 years old admitted for acute finger injury in the Emergency Department of a University Hospital during the first semester of 2019 and received a radiographic examination. Their demographic characteristics, fracture pattern, and treatment were then analyzed and interpreted.

Results:

Out of 478 finger injuries reviewed in this cohort, 160 X-rays revealed positive for a fracture giving a fracture rate of 33.5%. More than half of them (51.9%) occurred in the age group of adolescents (11–16 years). Among all finger fractures, only 3.8% of them treated surgically.

Conclusion:

In this study, a relevant amount of standard finger radiographs revealed a low fracture rate and a rare operative indication of 3.8%. Therefore, indications for X-rays should be reviewed properly and alternative procedures should be discussed. Clinical decision rules should be developed and the necessary pathways must be implemented to minimize radiation exposure, waiting time, and costs. Level of evidence: level IV
Bone transport in the management of post-osteomyelitis femoral defects in children: A case series with a minimum of 10-year follow-up in Uganda
Authors: Loro Antonio , Loro Francesca , Franceschi Fulvio , Brown Niall
Published: August 2022

Purpose:

The aim of this study was to evaluate the long-term outcomes of the bone transport technique in the management of post-infectious segmental femoral bone defects in children in a low-income country.

Methods:

Eleven children were included in this case series. All had a femoral defect secondary to osteomyelitis managed with the internal bone transport technique using an external fixator alone. Bone and functional results were evaluated and complications recorded after a minimum follow-up period of 10 years (range: 10–16).

Results:

The mean age of the patients was 7.8 years, and the average size of the bone defect was 10.8 cm. At the latest follow-up, bone results were excellent in three, good in five, and fair in three, while the functional results were excellent in three, good in four, fair in three, and poor in one. Limb length discrepancy was observed in 10 cases while hip and/or knee joint disorder was recorded in six cases. At the last follow-up, only one patient had a recurrence of infection.

Conclusion:

The bone transport technique has proven to be a valid option for eradicating infection and filling large bone defects in children. However, it is a technically difficult and lengthy procedure that is prone to unique complications.

Level of Evidence:

IV-Case series