bluuebunny/crossref_metadata_2025 huggingface dataset:
Glyburide Versus Metformin and Their Combination for the Treatment of Gestational Diabetes Mellitus: A Randomized Controlled Study
Authors: Nachum Zohar , Zafran Noah , Salim Raed , Hissin Noura , Hasanein Jamal , Gam Ze Letova Yifat , Suleiman Abeer , Yefet Enav
Published: January 2017

OBJECTIVE

To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM).

RESEARCH DESIGN AND METHODS

In this prospective randomized controlled study, we randomly assigned patients with GDM at 13–33 weeks gestation and whose blood glucose was poorly controlled by diet to receive either glyburide or metformin. If optimal glycemic control was not achieved, the other drug was added. If adverse effects occurred, the drug was replaced. If both failed, insulin was given. The primary outcomes were the rate of treatment failure and glycemic control after the first-line medication according to mean daily glucose charts.

RESULTS

Glyburide was started in 53 patients and metformin in 51. In the glyburide group, the drug failed in 18 (34%) patients due to adverse effects (hypoglycemia) in 6 (11%) and lack of glycemic control in 12 (23%). In the metformin group, the drug failed in 15 (29%) patients, due to adverse effects (gastrointestinal) in 1 (2%) and lack of glycemic control in 14 (28%). Treatment success after second-line therapy was higher in the metformin group than in the glyburide group (13 of 15 [87%] vs. 9 of 18 [50%], respectively; P = 0.03). In the glyburide group, nine (17%) patients were eventually treated with insulin compared with two (4%) in the metformin group (P = 0.03). The combination of the drugs reduced the need for insulin from 33 (32%) to 11 (11%) patients (P = 0.0002). Mean daily blood glucose and other obstetrical and neonatal outcomes were comparable between groups, including macrosomia, neonatal hypoglycemia, and electrolyte imbalance.

CONCLUSIONS

Glyburide and metformin are comparable oral treatments for GDM regarding glucose control and adverse effects. Their combination demonstrates a high efficacy rate with a significantly reduced need for insulin, with a possible advantage for metformin over glyburide as first-line therapy.
Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative
Authors: Neumayr Andreas , Muñoz Jose , Schunk Mirjam , Bottieau Emmanuel , Cramer Jakob , Calleri Guido , López-Vélez Rogelio , Angheben Andrea , Zoller Thomas , Visser Leo , Serre-Delcor Núria , Genton Blaise , Castelli Francesco , Van Esbroeck Marjan , Matteelli Alberto , Rochat Laurence , Sulleiro Elena , Kurth Florian , Gobbi Federico , Norman Francesca , Torta Ilaria , Clerinx Jan , Poluda David , Martinez Miguel , Calvo-Cano Antonia , Sanchez-Seco Maria Paz , Wilder-Smith Annelies , Hatz Christoph , Franco Leticia ,   for TropNet
Published: January 2017

We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012–13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014). We were able to characterise dengue viruses imported from regions where currently no virological surveillance data are available. Up to 36% of travellers infected with dengue while travelling returned during the acute phase of the infection (up to 7 days after symptom onset) or became symptomatic after returning to Europe, and 58% of the patients with acute dengue infection were viraemic when seeking medical care. Epidemiological and virological data from dengue-infected international travellers can add an important layer to global surveillance efforts. A considerable number of dengue-infected travellers are viraemic after arrival back home, which poses a risk for dengue introduction and autochthonous transmission in European regions where suitable mosquito vectors are prevalent.
The best teacher is the one who does not 'teach'!
Authors: Shankar P Ravi
Published: January 2017

Not available.Janaki Medical College Journal of Medical Sciences (2016) Vol. 4(1): 1-4
Mechanical properties, bond strength and microstructural evolution of AA1060/TiO2 composites fabricated by warm accumulative roll bonding (WARB)
Authors: Vini Mohammad Heydari , Sedighi Mohammad , Mondali Mehdi
Published: January 2017

In the present study, aluminum metal matrix composites reinforced with 5 % volume fraction of TiO2 particles were manufactured via warm accumulative roll bonding (WARB). The mechanical properties and microstructural evolution of composites fabricated by 1, 3, 5, 7, and 9 cycles of WARB were studied with application of tensile, peeling, and Vickers micro-hardness tests. Microstructural evolution during ARB cycles led to improvement of the strength and elongation properties of the samples. According to the results, uniform distribution of TiO2 clusters improved both the strength and tensile toughness of the composites. Finally, introduction of TiO2 particles into the Al matrix via WARB would allow fabricating particle-reinforced Al alloy with high uniformity and significantly enhance the mechanical properties and bond strength. Moreover, after the tensile and peeling tests, the fracture and peeling surfaces of the samples were studied at various WARB cycles using scanning electron microscopy.
Digital material representation concept applied to investigation of local inhomogeneities during manufacturing of magnesium components for automotive applications
Authors: Madej Lukasz , Ambrozinski Mateusz , Kwiecien Mateusz , Gronostajski Zbigniew , Pietrzyk Maciej
Published: January 2017

Multi-scale computer aided design of manufacturing processes of a magnesium bracket for the automotive industry is the main goal of the present paper. Tensile tests at various deformation conditions (temperatures, strain rates etc.) were performed to obtain flow stress data necessary for the macro-scale finite element analysis. The digital material representation concept was used to create a micro-scale model and to evaluate the influence of local microstructural features in the form of twins on material behaviour. An algorithm based on the cellular automata method capable of replicating microstructural morphology with twins was proposed to provide the digital material representation model. The bracket made of AZ31 magnesium alloy was formed at an elevated temperature of 200 °C. Description of the study as well as results obtained at two length scales are presented in the paper.
Development and Testing of a Device to Increase the Level of Automation of a Conventional Milking Parlor through Vocal Commands
Authors: Zaninelli Mauro
Published: January 2017

A portable wireless device with a “vocal commands” feature for activating the mechanical milking phase in conventional milking parlors was developed and tested to increase the level of automation in the milking procedures. The device was tested in the laboratory and in a milking parlor. Four professional milkers participated in the experiment. Before the start of the tests, a set of acoustic models with speaker-dependent commands defined for the project was acquired for each milker using a dedicated “milker training procedure”. Two experimental sessions were performed by each milker, with one session in the laboratory and a subsequent session in the milking parlor. The device performance was evaluated based on the accuracy demonstrated in the vocal command recognition task and rated using the word recognition rate (WRR). The data were expressed as %WRR and grouped based on the different cases evaluated. Mixed effects logistic regression modeling was used to evaluate the association between the %WRR and explanatory variables. The results indicated significant effects due to the location where the tests were performed. Higher values of the %WRR were found for tests performed in the laboratory, whereas lower values were found for tests performed in the milking parlor (due to the presence of background noise). Nevertheless, the general performance level achieved by the device was sufficient for increasing the automation level of conventional milking parlors.
Analysis of Thermo-Elastic Fracture Problem during Aluminium Alloy MIG Welding Using the Extended Finite Element Method
Authors: He Kuanfang , Yang Qing , Xiao Dongming , Li Xuejun
Published: January 2017

The thermo-elastic fracture problem and equations are established for aluminium alloy Metal Inert Gas (MIG) welding, which include a moving heat source and a thermoelasticity equation with the initial and boundary conditions for a plate structure with a crack. The extended finite element method (XFEM) is implemented to solve the thermo-elastic fracture problem of a plate structure with a crack under the effect of a moving heat source. The combination of the experimental measurement and simulation of the welding temperature field is done to verify the model and solution method. The numerical cases of the thermomechanical parameters and stress intensity factors (SIFs) of the plate structure in the welding heating and cooling processes are investigated. The research results provide reference data and an approach for the analysis of the thermomechanical characteristics of the welding process.
Theoretical Analysis of Effective Thermal Conductivity for the Chinese HTR-PM Heat Transfer Test Facility
Authors: Ren Cheng , Yang Xingtuan , Jia Haijun , Jiang Yueyuan , Xiong Wei
Published: January 2017

The Chinese high temperature gas-cooled reactor pebble bed module (HTR-PM) demonstration project has attracted increasing attention. In order to support the project, a large-scale heat transfer test facility has been constructed for pebble bed effective thermal conductivity measurement over the whole temperature range (0~1600 °C). Based on different heat transfer mechanisms in the randomly packed pebble bed, three different types of effective thermal conductivity have been theoretically evaluated. A prediction of the total effective thermal conductivity of the pebble bed over the whole temperature range is provided for the optimization of the test facility and guidance of further experiments.
Combining Multiconfiguration and Perturbation Methods: Perturbative Estimates of Core–Core Electron Correlation Contributions to Excitation Energies in Mg-Like Iron
Authors: Gustafsson Stefan , Jönsson Per , Froese Fischer Charlotte , Grant Ian
Published: January 2017

Large configuration interaction (CI) calculations can be performed if part of the interaction is treated perturbatively. To evaluate the combined CI and perturbative method, we compute excitation energies for the 3 l 3 l ′ , 3 l 4 l ′ and 3 s 5 l states in Mg-like iron. Starting from a CI calculation including valence and core–valence correlation effects, it is found that the perturbative inclusion of core–core electron correlation halves the mean relative differences between calculated and observed excitation energies. The effect of the core–core electron correlation is largest for the more excited states. The final relative differences between calculated and observed excitation energies is 0.023%, which is small enough for the calculated energies to be of direct use in line identifications in astrophysical and laboratory spectra.
Acknowledgement to Reviewers of Biomolecules in 2016
Authors:   Biomolecules Editorial Office
Published: January 2017

The editors of Biomolecules would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Acknowledgement to Reviewers of Biomedicines in 2016
Authors:   Biomedicines Editorial Office
Published: January 2017

The editors of Biomedicines would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers
Authors: Smolsky Joseph , Kaur Sukhwinder , Hayashi Chihiro , Batra Surinder , Krasnoslobodtsev Alexey
Published: January 2017

Detection of biomarkers is of vital importance in disease detection, management, and monitoring of therapeutic efficacy. Extensive efforts have been devoted to the development of novel diagnostic methods that detect and quantify biomarkers with higher sensitivity and reliability, contributing to better disease diagnosis and prognosis. When it comes to such devastating diseases as cancer, these novel powerful methods allow for disease staging as well as detection of cancer at very early stages. Over the past decade, there have been some advances in the development of platforms for biomarker detection of diseases. The main focus has recently shifted to the development of simple and reliable diagnostic tests that are inexpensive, accurate, and can follow a patient’s disease progression and therapy response. The individualized approach in biomarker detection has been also emphasized with detection of multiple biomarkers in body fluids such as blood and urine. This review article covers the developments in Surface-Enhanced Raman Scattering (SERS) and related technologies with the primary focus on immunoassays. Limitations and advantages of the SERS-based immunoassay platform are discussed. The article thoroughly describes all components of the SERS immunoassay and highlights the superior capabilities of SERS readout strategy such as high sensitivity and simultaneous detection of a multitude of biomarkers. Finally, it introduces recently developed strategies for in vivo biomarker detection using SERS.
Exosomes in Cancer Diagnostics
Authors: Soung Young , Ford Shane , Zhang Vincent , Chung Jun
Published: January 2017

Exosomes are endosome derived extracellular vesicles of 30–120 nm size ranges. Exosomes have been identified as mediators of cell-to-cell communication by transferring bioactive molecules such as nucleic acids, proteins and lipids into recipient cells. While exosomes are secreted by multiple cell types, cancer derived exosomes not only influence the invasive potentials of proximally located cells, but also affect distantly located tissues. Based on their ability to alter tumor microenvironment by regulating immunity, angiogenesis and metastasis, there has been growing interest in defining the clinical relevance of exosomes in cancers. In particular, exosomes are valuable sources for biomarkers due to selective cargo loading and resemblance to their parental cells. In this review, we summarize the recent findings to utilize exosomes as cancer biomarkers for early detection, diagnosis and therapy selection.
Acknowledgement to Reviewers of Chemosensors in 2016
Authors:   Chemosensors Editorial Office
Published: January 2017

The editors of Chemosensors would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
An Evaluation of the Accuracy of the Subtraction Method Used for Determining Platelet Counts in Advanced Platelet-Rich Fibrin and Concentrated Growth Factor Preparations
Authors: Watanabe Taisuke , Isobe Kazushige , Suzuki Taiji , Kawabata Hideo , Nakamura Masayuki , Tsukioka Tsuneyuki , Okudera Toshimitsu , Okudera Hajime , Uematsu Kohya , Okuda Kazuhiro , Nakata Koh , Kawase Tomoyuki
Published: January 2017

Platelet concentrates should be quality-assured of purity and identity prior to clinical use. Unlike for the liquid form of platelet-rich plasma, platelet counts cannot be directly determined in solid fibrin clots and are instead calculated by subtracting the counts in other liquid or semi-clotted fractions from those in whole blood samples. Having long suspected the validity of this method, we herein examined the possible loss of platelets in the preparation process. Blood samples collected from healthy male donors were immediately centrifuged for advanced platelet-rich fibrin (A-PRF) and concentrated growth factors (CGF) according to recommended centrifugal protocols. Blood cells in liquid and semi-clotted fractions were directly counted. Platelets aggregated on clot surfaces were observed by scanning electron microscopy. A higher centrifugal force increased the numbers of platelets and platelet aggregates in the liquid red blood cell fraction and the semi-clotted red thrombus in the presence and absence of the anticoagulant, respectively. Nevertheless, the calculated platelet counts in A-PRF/CGF preparations were much higher than expected, rendering the currently accepted subtraction method inaccurate for determining platelet counts in fibrin clots. To ensure the quality of solid types of platelet concentrates chairside in a timely manner, a simple and accurate platelet-counting method should be developed immediately.
A Modular Integrated RFID System for Inventory Control Applications
Authors: Bunker Ross , Elsherbeni Atef
Published: January 2017

Recent advances in single-board computer technology have allowed for lightweight, power-efficient devices, such as the Raspberry Pi, to take the place of desktop PCs in certain applications. This has the potential to disrupt the way many current systems are structured, particularly for inventory management and control applications. In this paper, we explore the design and topology of a modular Radio frequency identification (RFID) system for inventory management comprised of self-contained, autonomous scanning, and stationary control PCs in a handheld/portable configuration. While similar solutions for such a system may exist on the commercial market, this proposed development provides a template for an open source flexible, low-cost solution that can be easily expanded to meet the needs of businesses with large and small inventories.
Equivalence of Primary Control Strategies for AC and DC Microgrids
Authors: Unamuno Eneko , Barrena Jon
Published: January 2017

Microgrid frequency and voltage regulation is a challenging task, as classical generators with rotational inertia are usually replaced by converter-interfaced systems that inherently do not provide any inertial response. The aim of this paper is to analyse and compare autonomous primary control techniques for alternating current (AC) and direct current (DC) microgrids that improve this transient behaviour. In this context, a virtual synchronous machine (VSM) technique is investigated for AC microgrids, and its behaviour for different values of emulated inertia and droop slopes is tested. Regarding DC microgrids, a virtual-impedance-based algorithm inspired by the operation concept of VSMs is proposed. The results demonstrate that the proposed strategy can be configured to have an analogous behaviour to VSM techniques by varying the control parameters of the integrated virtual-impedances. This means that the steady-state and transient behaviour of converters employing these strategies can be configured independently. As shown in the simulations, this is an interesting feature that could be, for instance, employed for the integration of different dynamic generation or storage systems, such as batteries or supercapacitors.
A Theoretical Analysis for Assessing the Variability of Secondary Model Thermal Inactivation Kinetic Parameters
Authors: Giannakourou Maria , Stoforos Nikolaos
Published: January 2017

Traditionally, for the determination of the kinetic parameters of thermal inactivation of a heat labile substance, an appropriate index is selected and its change is measured over time at a series of constant temperatures. The rate of this change is described through an appropriate primary model and a secondary model is applied to assess the impact of temperature. By this approach, the confidence intervals of the estimates of the rate constants are not taken into account. Consequently, the calculated variability of the secondary model parameters can be significantly lower than the actual variability. The aim of this study was to demonstrate the influence of the variability of the primary model parameters in establishing the confidence intervals of the secondary model parameters. Using a Monte Carlo technique and assuming normally distributed DT values (parameter associated with a primary inactivation model), the error propagating on the DTref and z-values (secondary model parameters) was assessed. When DT confidence intervals were broad, the secondary model’s parameter variability was appreciably high and could not be adequately estimated through the traditional deterministic approach that does not take into account the variation on the DT values. In such cases, the proposed methodology was essential for realistic estimations.
Erratum: Pan Y. et al. Cucumber Metallothionein-Like 2 (CsMTL2) Exhibits Metal-Binding Properties. Genes 2016, 7, 106
Authors:   Genes Editorial Office
Published: January 2017

n/a
Impact of Hospital Design on Acutely Unwell Patients with Dementia
Authors: Young Caitlin , Edwards Chris , Singh Inderpal
Published: January 2017

Increasing emphasis on patient privacy and satisfaction has seen more 100% single-room hospitals opened across the UK. Few studies have addressed the impact of these new hospital designs (single rooms) on clinical outcomes specifically for acutely unwell frail patients with dementia. The objective of this study was to profile and compare the clinical outcomes of acutely unwell patients with dementia admitted to two different hospital environments. This prospective observation study was conducted for 100 dementia patients admitted at Ysbyty Ystrad Fawr (hospital with 100% single rooms) and Royal Gwent Hospital (traditional multi-bed wards) under the same University Health Board. The length of stay (LoS) was significantly longer for patients admitted to single rooms. The clinical profile of the patients was similar in both hospitals and has no association with LoS. There was no significant difference in terms of incidence of inpatient falls, fall-related injury, discharge to a new care home, 30-day readmission, or mortality. The single room environment appears to influence LoS, as previously reported; however, following the introduction of quality improvement initiatives to prevent inpatient falls, single rooms do not appear to be associated with higher inpatient fall incidence. We propose more research to understand the relationship between single rooms and LoS.
Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling
Authors: Yang Jian-Guang , Lu Rui , Ye Xiao-Jing , Zhang Jing , Tan Ya-Qin , Zhou Gang
Published: January 2017

Icaritin, a traditional Chinese medicine, possesses antitumor activity. The current study aimed to investigate icaritin effect and potential mechanism on oral squamous cell carcinoma (OSCC) development. OSCC cells proliferation, apoptosis, and autophagy were analyzed after incubation with icaritin at different concentrations and incubation times. The expressions of proteins related to proliferation, apoptosis, and autophagy, as well as signal transducer and activator of transcription 3 (STAT3) signal network, were also evaluated by western blot. Furthermore, STAT3 was knocked down by siRNA transfection to determine STAT3 role in OSCC cell proliferation and apoptosis. An oral specific carcinogenesis mouse model was used to explore icaritin effect on OSCC in vivo. Icaritin significantly inhibited OSCC proliferation in vitro and reduced the expression of both the cell-cycle progression proteins cyclin A2 and cyclin D1. Besides, icaritin increased cleaved caspase 3 and cleaved poly-(ADP-ribose) polymerase expression leading to apoptosis, and it activated autophagy. Icaritin significantly inhibited the expression of phospho-STAT3 (p-STAT3) in a dose- and time-dependent manner. In the in vivo experiment, the number of malignant tumors in the icaritin-treated group was significantly lower than the control. Overall, icaritin suppressed proliferation, promoted apoptosis and autophagy, and inhibited STAT3 signaling in OSCC in vitro and in vivo. In conclusion, icaritin might be a potential therapeutic agent against OSCC development.
Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions
Authors: Tomasetti Carmine , Iasevoli Felice , Buonaguro Elisabetta , De Berardis Domenico , Fornaro Michele , Fiengo Annastasia , Martinotti Giovanni , Orsolini Laura , Valchera Alessandro , Di Giannantonio Massimo , De Bartolomeis Andrea
Published: January 2017

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological key determinants of major psychotic disorders, above all schizophrenia and mood disorders. For the most part, synaptic interactions between dopamine and glutamate signaling pathways take part in the postsynaptic density, a specialized ultrastructure localized under the membrane of glutamatergic excitatory synapses. Multiple proteins, with the role of adaptors, regulators, effectors, and scaffolds compose the postsynaptic density network. They form structural and functional crossroads where multiple signals, starting at membrane receptors, are received, elaborated, integrated, and routed to appropriate nuclear targets. Moreover, transductional pathways belonging to different receptors may be functionally interconnected through postsynaptic density molecules. Several studies have demonstrated that psychopharmacologic drugs may differentially affect the expression and function of postsynaptic genes and proteins, depending upon the peculiar receptor profile of each compound. Thus, through postsynaptic network modulation, these drugs may induce dopamine-glutamate synaptic remodeling, which is at the basis of their long-term physiologic effects. In this review, we will discuss the role of postsynaptic proteins in dopamine-glutamate signals integration, as well as the peculiar impact of different psychotropic drugs used in clinical practice on postsynaptic remodeling, thereby trying to point out the possible future molecular targets of “synapse-based” psychiatric therapeutic strategies.
Multiple Activities of Punica granatum Linne against Acne Vulgaris
Authors: Lee Chia-Jung , Chen Lih-Geeng , Liang Wen-Li , Wang Ching-Chiung
Published: January 2017

Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E2 production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker.
Information Theoretic Source Seeking Strategies for Multiagent Plume Tracking in Turbulent Fields
Authors: Hajieghrary Hadi , Mox Daniel , Hsieh M.
Published: January 2017

We present information theoretic search strategies for single and multi-robot teams to localize the source of biochemical contaminants in turbulent flows. The robots synthesize the information provided by sporadic and intermittent sensor readings to optimize their exploration strategy. By leveraging the spatio-temporal sensing capabilities of a mobile sensing network, our strategies result in control actions that maximize the information gained by the team while minimizing the time spent localizing the biochemical source. By leveraging the team’s ability to obtain simultaneous measurements at different locations, we show how a multi-robot team is able to speed up the search process resulting in a collaborative information theoretic search strategy. We validate our proposed strategies in both simulations and experiments.
Comprehensive Quantitative Analysis of 32 Chemical Ingredients of a Chinese Patented Drug Sanhuang Tablet
Authors: Fung Hau-Yee , Lang Yan , Ho Hing-Man , Wong Tin-Long , Ma Dik-Lung , Leung Chung-Hang , Han Quan-Bin
Published: January 2017

Sanhuang Tablet (SHT) is a Chinese patented drug commonly used for the treatment of inflammations of the respiratory tract, gastrointestinal tract, and skin. It contains a special medicinal composition including the single compound berberine hydrochloride, extracts of Scutellariae Radix and Rhei Radix et Rhizoma, as well as the powder of Rhei Radix et Rhizoma. Despite advances in analytical techniques, quantitative evaluation of a Chinese patented drug like SHT remains a challenge due to the complexity of its chemical profile. In this study, ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was used to simultaneously quantify 29 non-sugar small molecule components of SHT (11 flavonoids, two isoflavonoids, one flavanone, five anthraquinones, two dianthranones, five alkaloids, two organic acids and one stilbene). Three major saccharide components, namely fructose, glucose, and sucrose, were also quantitatively determined using high performance liquid chromatography-charged aerosol detector (HPLC-CAD) on an Asahipak NH2P-50 4E amino column. The established methods were validated in terms of linearity, sensitivity, precision, accuracy, and stability, and then successfully applied to analyze 27 batches of commercial SHT products. A total of up to 57.61% (w/w) of SHT could be quantified, in which the contents of the determined non-saccharide small molecules varied from 5.91% to 16.83% (w/w) and three saccharides accounted for 4.41% to 48.05% (w/w). The results showed that the quality of the commercial products was inconsistent, and only four of those met Chinese Pharmacopoeia criteria.
Natural Products and Inflammation
Authors: Latruffe Norbert
Published: January 2017

Inflammation (or inflammatory reaction) is the response to body aggression by a pathogen agent, an allergen, a toxic compound, a tissue lesion, etc.[...]
Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation
Authors: Kim Dong-Kyu , Kweon Ki-Jung , Kim Pyungsoo , Kim Hee-Jung , Kim Sung-Soo , Sohn Nak-Won , Maeng Sungho , Shin Jung-Won
Published: January 2017

Spinal cord injury (SCI) is one of the most devastating medical conditions; however, currently, there are no effective pharmacological interventions for SCI. Ginsenoside Rg3 (GRg3) is one of the protopanaxadiols that show anti-inflammatory, anti-oxidant, and neuroprotective effects. The present study investigated the neuroprotective effect of GRg3 following SCI in rats. SCI was induced using a static compression model at vertebral thoracic level 10 for 5 min. GRg3 was administrated orally at a dose of 10 or 30 mg/kg/day for 14 days after the SCI. GRg3 (30 mg/kg) treatment markedly improved behavioral motor functions, restored lesion size, preserved motor neurons in the spinal tissue, reduced Bax expression and number of TUNEL-positive cells, and suppressed mRNA expression of pro-inflammatory cytokines including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. GRg3 also attenuated the over-production of cyclooxygenase-2 and inducible nitric oxide synthase after SCI. Moreover, GRg3 markedly suppressed microglial activation in the spinal tissue. In conclusion, GRg3 treatment led to a remarkable recovery of motor function and a reduction in spinal tissue damage by suppressing neuronal apoptosis and inflammatory responses after SCI. These results suggest that GRg3 may be a potential therapeutic agent for the treatment of SCI.
Preparation of g-C3N4/Graphene Composite for Detecting NO2 at Room Temperature
Authors: Zhang Shaolin , Hang Nguyen , Zhang Zhijun , Yue Hongyan , Yang Woochul
Published: January 2017

Graphitic carbon nitride (g-C3N4) nanosheets were exfoliated from bulk g-C3N4 and utilized to improve the sensing performance of a pure graphene sensor for the first time. The role of hydrochloric acid treatment on the exfoliation result was carefully examined. The exfoliated products were characterized by X-ray diffraction (XRD) patterns, scanning electron microscopy (SEM), atomic force microscopy (AFM), and UV-Vis spectroscopy. The exfoliated g-C3N4 nanosheets exhibited a uniform thickness of about 3–5 nm and a lateral size of about 1–2 µm. A g-C3N4/graphene nanocomposite was prepared via a self-assembly process and was demonstrated to be a promising sensing material for detecting nitrogen dioxide gas at room temperature. The nanocomposite sensor exhibited better recovery as well as two-times the response compared to pure graphene sensor. The detailed sensing mechanism was then proposed.
Parametrically Optimized Carbon Nanotube-Coated Cold Cathode Spindt Arrays
Authors: Yuan Xuesong , Cole Matthew , Zhang Yu , Wu Jianqiang , Milne William , Yan Yang
Published: January 2017

Here, we investigate, through parametrically optimized macroscale simulations, the field electron emission from arrays of carbon nanotube (CNT)-coated Spindts towards the development of an emerging class of novel vacuum electron devices. The present study builds on empirical data gleaned from our recent experimental findings on the room temperature electron emission from large area CNT electron sources. We determine the field emission current of the present microstructures directly using particle in cell (PIC) software and present a new CNT cold cathode array variant which has been geometrically optimized to provide maximal emission current density, with current densities of up to 11.5 A/cm2 at low operational electric fields of 5.0 V/μm.
Acknowledgement to Reviewers of Nanomaterials in 2016
Authors:   Nanomaterials Editorial Office
Published: January 2017

The editors of Nanomaterials would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Acknowledgement to Reviewers of Nutrients in 2016
Authors:   Editorial Office
Published: January 2017

The editors of Nutrients would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Assessment of the Sustainability of the Mediterranean Diet Combined with Organic Food Consumption: An Individual Behaviour Approach
Authors: Seconda Louise , Baudry Julia , Allès Benjamin , Hamza Oualid , Boizot-Szantai Christine , Soler Louis-Georges , Galan Pilar , Hercberg Serge , Lairon Denis , Kesse-Guyot Emmanuelle
Published: January 2017

Mediterranean diets are promising sustainable food models and the organic food system may provide health and environmental benefits. Combining the two models could therefore be a favourable approach for food sustainability. The aim of this study was to draw up a comparative description of four diets differing in the level of organic foods consumption and the adherence to the Mediterranean diet, using multidisciplinary indicators to assess the sustainability of these diets. Four groups of participants were defined and compared, combining the proportion of organic food in their diet (Org versus Conv) and the adherence to the Mediterranean diet (Med versus NoMed). Conv–NoMed: Conventional consumers and non-Mediterranean diet followers; Conv–Med: Conventional consumers and Mediterranean diet followers; Org–NoMed: Organic consumers and non-Mediterranean diet followers; Org–Med: Organic consumers and Mediterranean diet followers. The adherence to nutritional recommendations was higher among the Org–Med and Conv–Med groups compared to the Conv–NoMed group (using the mPNNS-GS (modified-Programme National nutrition santé guidelines score/13.5 points): 9.29 (95% confidence intervals (CI) = 9.23–9.36) and 9.30 (95% CI = 9.24–9.35) versus 8.19 (95% CI = 8.17–8.22)) respectively. The mean plant/animal protein intake ratio was 1.38 (95% CI = 1.01–1.74) for the Org–Med group versus 0.44 (95% CI = 0.28–0.60) for the Conv–NoMed group. The average cost of the diet of Org–Med participants was the highest: 11.43 €/day (95% CI = 11.34–11.52). This study highlighted the importance of promoting the Mediterranean diet combined with organic food consumption for individual health and environmental aspects but challenges with regard to the cost remain.
Acknowledgement to Reviewers of Remote Sensing in 2016
Authors:   Remote Sensing Editorial Office
Published: January 2017

The editors of Remote Sensing would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Intercomparison of XH2O Data from the GOSAT TANSO-FTS (TIR and SWIR) and Ground-Based FTS Measurements: Impact of the Spatial Variability of XH2O on the Intercomparison
Authors: Ohyama Hirofumi , Kawakami Shuji , Shiomi Kei , Morino Isamu , Uchino Osamu
Published: January 2017

Spatial and temporal variability of atmospheric water vapor (H2O) is extremely high, and therefore it is difficult to accurately evaluate the measurement precision of H2O data by a simple comparison between the data derived from two different instruments. We determined the measurement precisions of column-averaged dry-air mole fractions of H2O (XH2O) retrieved independently from spectral radiances in the thermal infrared (TIR) and the short-wavelength infrared (SWIR) regions measured using a Thermal And Near-infrared Sensor for carbon Observation-Fourier Transform Spectrometer (TANSO-FTS) onboard the Greenhouse gases Observing SATellite (GOSAT), by an intercomparison between the two TANSO-FTS XH2O data products and the ground-based FTS XH2O data. Furthermore, the spatial variability of XH2O was also estimated in the intercomparison process. Mutually coincident XH2O data above land for the period ranging from April 2009 to May 2014 were intercompared with different spatial coincidence criteria. We found that the precisions of the TANSO-FTS TIR and TANSO-FTS SWIR XH2O were 7.3%–7.7% and 3.5%–4.5%, respectively, and that the spatial variability of XH2O was 6.7% within a radius of 50 km and 18.5% within a radius of 200 km. These results demonstrate that, in order to accurately evaluate the measurement precision of XH2O, it is necessary to set more rigorous spatial coincidence criteria or to take into account the spatial variability of XH2O as derived in the present study.
Wearable Sensors for Remote Health Monitoring
Authors: Majumder Sumit , Mondal Tapas , Deen M.
Published: January 2017

Life expectancy in most countries has been increasing continually over the several few decades thanks to significant improvements in medicine, public health, as well as personal and environmental hygiene. However, increased life expectancy combined with falling birth rates are expected to engender a large aging demographic in the near future that would impose significant burdens on the socio-economic structure of these countries. Therefore, it is essential to develop cost-effective, easy-to-use systems for the sake of elderly healthcare and well-being. Remote health monitoring, based on non-invasive and wearable sensors, actuators and modern communication and information technologies offers an efficient and cost-effective solution that allows the elderly to continue to live in their comfortable home environment instead of expensive healthcare facilities. These systems will also allow healthcare personnel to monitor important physiological signs of their patients in real time, assess health conditions and provide feedback from distant facilities. In this paper, we have presented and compared several low-cost and non-invasive health and activity monitoring systems that were reported in recent years. A survey on textile-based sensors that can potentially be used in wearable systems is also presented. Finally, compatibility of several communication technologies as well as future perspectives and research challenges in remote monitoring systems will be discussed.
On Connectivity of Wireless Sensor Networks with Directional Antennas
Authors: Wang Qiu , Dai Hong-Ning , Zheng Zibin , Imran Muhammad , Vasilakos Athanasios
Published: January 2017

In this paper, we investigate the network connectivity of wireless sensor networks with directional antennas. In particular, we establish a general framework to analyze the network connectivity while considering various antenna models and the channel randomness. Since existing directional antenna models have their pros and cons in the accuracy of reflecting realistic antennas and the computational complexity, we propose a new analytical directional antenna model called the iris model to balance the accuracy against the complexity. We conduct extensive simulations to evaluate the analytical framework. Our results show that our proposed analytical model on the network connectivity is accurate, and our iris antenna model can provide a better approximation to realistic directional antennas than other existing antenna models.
Adaptive Information Dissemination Control to Provide Diffdelay for the Internet of Things
Authors: Liu Xiao , Liu Anfeng , Huang Changqin
Published: January 2017

Applications running on the Internet of Things, such as the Wireless Sensor and Actuator Networks (WSANs) platform, generally have different quality of service (QoS) requirements. For urgent events, it is crucial that information be reported to the actuator quickly, and the communication cost is the second factor. However, for interesting events, communication costs, network lifetime and time all become important factors. In most situations, these different requirements cannot be satisfied simultaneously. In this paper, an adaptive communication control based on a differentiated delay (ACCDS) scheme is proposed to resolve this conflict. In an ACCDS, source nodes of events adaptively send various searching actuators routings (SARs) based on the degree of sensitivity to delay while maintaining the network lifetime. For a delay-sensitive event, the source node sends a large number of SARs to actuators to identify and inform the actuators in an extremely short time; thus, action can be taken quickly but at higher communication costs. For delay-insensitive events, the source node sends fewer SARs to reduce communication costs and improve network lifetime. Therefore, an ACCDS can meet the QoS requirements of different events using a differentiated delay framework. Theoretical analysis simulation results indicate that an ACCDS provides delay and communication costs and differentiated services; an ACCDS scheme can reduce the network delay by 11.111%–53.684% for a delay-sensitive event and reduce the communication costs by 5%–22.308% for interesting events, and reduce the network lifetime by about 28.713%.
New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates
Authors: Azotla-Cruz Liliana , Lijanova Irina , Ukrainets Igor , Likhanova Natalya , Olivares-Xometl Octavio , Bereznyakova Natalya
Published: January 2017

According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics. In addition, a fundamentally new strategy for the synthesis of compounds of this chemical class involving the introduction of N-alkyl substituent at the final stage in 2,1-benzothiazine nucleus already formed has been proposed. Using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and X-ray diffraction analysis it has been proven that in the DMSO/K2CO3 system the reaction of methyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and alkyl halides leads to formation of N-substituted derivatives with good yields regardless of the structure of the alkylating agent. The peculiarities of NMR (1Н and 13С) spectra of the compounds synthesized, their mass spectrometric behavior and the spatial structure are discussed. In N-benzyl derivative the ability to form a monosolvate with methanol has been found. According to the results of the pharmacological testing conducted on the model of the thermal tail-flick it has been determined that replacement of 4-ОН-group in methyl 1-R-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates for the methyl group is actually bioisosteric since all methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates synthesized demonstrated a statistically significant analgesic effect. The majority of the substances can inhibit the thermal pain response much more effective than piroxicam in the same dose. Under the same conditions as an analgesic the N-methyl-substituted analog exceeds not only piroxicam, but more active meloxicam as well. Therefore, it deserves in-depth biological studies on other experimental models.
Fast Removal of Polybrominated Diphenyl Ethers from Aqueous Solutions by Using Low-Cost Adsorbents
Authors: Chang Renin , Jien Shih-Hao , Weng Chih-Huang , Lee Tsung-Wei , Liao Chien-Sen
Published: January 2017

4-Dibromodiphenyl ether (BDE-3) and 4,4′-dibromodiphenyl ether (BDE-15) are two of the major polybrominated diphenyl ethers used as flame-retardant additives in computer main boards and in fireproof building materials. In this study, we evaluated the potential of three low-cost adsorbents, black tea, green tea, and coconut palm leaf powders, to adsorb BDE-3 and BDE-15 from aqueous solutions. The results showed that pressure steam washing of the adsorbents increased their capacities to adsorb BDE-3 and BDE-15. The maximum adsorption capacities of pressure steam–washed black tea, green tea, and coconut palm leaf powders were 21.85 mg·L−1, 14.56 mg·L−1 and 22.47 mg·L−1, respectively. The results also showed that the adsorption equilibrium (qe) was achieved at 4 min. Moreover, 97.8% of BDE-3 and 98.5% of BDE-15 could be removed by adsorbents pretreated with pressure steam washing. The kinetic data fitted well with a pseudo-second-order equation. The adsorption rate constants (k2) of all pressure steam–washed adsorbents ranged from 8.16 × 10−3 to 6.61 × 10−2 g·(mg·L−1)−1·s−1, and the amount adsorbed at qe by all pressure steam–washed adsorbents ranged from 4.21 to 4.78 mg·L−1. Green alga Chlorella vulgaris was used as the test organism and the median effective concentration values of BDE-3 and BDE-15 were 7.24 and 3.88 mg·L−1, respectively. After BDE-3 and BDE-15 were removed from the solution, their biotoxicities markedly decreased. These findings indicate that these low-cost adsorbents can be used to remove BDE-3 and BDE-15 from aqueous solutions and wastewater.