bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-Reported Outcome Measurements in Patients with COPD-Obstructive Sleep Apnea Overlap Syndrome: Time for Action?
Authors: Papaioannou Andriana I , Fouka Evangelia , Nena Evangelia , Bakakos Petros , Steiropoulos Paschalis
Published: November 2022

Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) are common conditions that often coexist [Overlap syndrome (OS)]. OS has important implications in the diagnosis, treatment, and patient outcome of both disorders. Patient-reported outcomes (PROs) are essential to evaluate symptoms, impact of symptoms on activities of daily living, and treatment response. The present review aims to display the potential usefulness of PROs measurements (PROMs) regarding the initial evaluation and treatment of both conditions (COPD and OSA) in OS patients. More specifically, we review PROMs regarding symptoms, mental health indices and health-related quality of life in patients with OS. These PROMs have the potential to add value to clinical research and daily practice in certain aspects that are important to patients.
Mechanical and Metallurgical Characterization of Nickel-Titanium Wire Types for Rotary Endodontic Instrument Manufacture
Authors: Chien Philip Y-H. , Martins Jorge N. R. , Walsh Laurence J. , Peters Ove A.
Published: November 2022

This study aimed to evaluate and compare the effects of ambient temperature and post-manufacture heat-treatment on the mechanical behavior of nickel-titanium (NiTi) wires. Four types of commercial NiTi variants (Stock NiTi, heat treated “Blue”, “Gold”, “Superflex”, all Dentsply Maillefer, Ballaigues, Switzerland) were stressed in a tensile testing machine in a temperature-controlled water bath at three different temperatures. Stress and strain values were extrapolated from the raw data, and 2-way ANOVA and Tukey’s test for multiple comparisons were performed to compare the differences of the mechanical constants. Differential scanning calorimetry (DSC) tests established the martensitic transformation starting (Ms), finishing (Mf) and austenitic (reverse-martensitic) starting (As) and finishing (Af) points. Austenitic modulus of elasticity and transformation stress values increased with temperature for all NiTi groups. The martensitic modulus of elasticity, maximum transformation strain and ultimate tensile stress were not significantly affected by temperature changes. Stock NiTi and Gold wire samples presented with clearly delineated austenitic and martensitic transformations in the DSC experiments. Differences in manufacturing/heat treatment conditions and ambient temperature affect the mechanical behavior of nickel-titanium and may have clinical implications. Further improvements to the experimental setup could be considered to provide more accurate measurements of strain.
Developed a New Radiation Shielding Absorber Composed of Waste Marble, Polyester, PbCO3, and CdO to Reduce Waste Marble Considering Environmental Safety
Authors: Sayyed M. I. , Almurayshid Mansour , Almasoud Fahad I. , Alyahyawi Amjad R. , Yasmin Sabina , Elsafi Mohamed
Published: November 2022

The usage of radiation is mandatory for modern life; in the same manner, controlling the outflow of harmful radiation is vital and could be achieved via employing a shielding material to eliminate any potential nuclear and radiation accidents and incidents. Considering this point, this study aims to manufacture composite samples based on waste marble as novel radiation shields. The physical and radiation shielding ability of the prepared shields were determined and analyzed. For this purpose, a high-purity germanium (HPGe) detector was used to detect the incoming photons emitted from three point sources (Am-241, Cs-137, and Co-60). The radiation attenuation factors for the new marble-based composites were measured for some energies, ranging from 0.06 to 1.333 MeV. We examined the effect of increasing the PbCO3 and CdO contents on the physical properties and radiation attenuation factors of the newly developed radiation shielding absorber. We found that the density of the samples increases from 1.784 to 1.796 g/cm3 when the CdO changes from 0 to 12.5 wt%. The linear attenuation coefficient (LAC) for all marble compositions has the maximum value at 0.06 MeV, while the LAC decreases with increasing energy. The highest LAC was found for Marb-3, with a composition of waste marble (50 wt%), polyester (25 wt%), PbCO3 (17.5 wt%), and CdO (7.5 wt%). We studied the impact of the addition of CdO on the expense of PbCO3 and we found that the half value layer (HVL) decreases with increasing the CdO content. Hence, when there is no space problem, the newly developed radiation shielding absorber can be used to maintain the cost effectiveness and environmentally friendliness of products.
Identification of a Workpiece Temperature Compensation Model for Automatic Correction of the Cutting Process
Authors: Zawada-Tomkiewicz Anna , Tomkiewicz Dariusz , Pela Michał
Published: November 2022

This article describes a system for measuring and compensating for errors resulting from the cutting process in order to improve the accuracy of the workpiece. Measurements were performed by means of an automatic measurement unit. The diameter of the workpiece was measured at two points, and at the same time, the temperature at the end face of the workpiece was measured. These measurements were used in Statistical Process Control (SPC). Based on the measured values, the process stability was checked and an error correction value was determined for the next item. Moreover, the value of the correction was influenced by the assumed value of tool wear, in accordance with the adopted model, and the possibility of achieving the assumed surface quality. The diameter of the workpiece for SPC purposes was measured under industrial conditions using an automatic measurement unit, which indicates that the temperature of the workpiece during the measurement was significantly higher than the reference temperature. The study focuses on the possibility of identifying a workpiece temperature compensation model in measurements of the workpiece diameter for the purpose of introducing an additional change in the correction value. It was found that a model with a constant correction value and a linear model poorly reflect the nature of the changes. On the other hand, the Autoregressive with Extra Input (ARX) model and the Nonlinear Autoregressive with Extra Input (NLARX) model, with a neural network, are able to map the inertia of the system and map the process with greater accuracy. In this way, measurements performed in industrial conditions can more accurately determine the possibility of achieving the assumed tolerance of the finished product. At the same time, the research shows that the temperature compensation model is nonlinear, and that the maximum possible machining accuracy of the workpiece can be achieved thanks to the repeatable measurement and compensation technique.
Corrosion Resistance of 316L/CuSn10 Multi-Material Manufactured by Powder Bed Fusion
Authors: Kremer Robert , Etzkorn Johannes , Palkowski Heinz , Foadian Farzad
Published: November 2022

Research and industry are calling for additively manufactured multi-materials, as these are expected to create more efficient components, but there is a lack of information on corrosion resistance, especially since there is a risk of bimetallic corrosion with two metallic components. In this study, the corrosion behaviour of a multi-material made of 316L and CuSn10 is investigated before and after a stress relief annealing using linear sweep voltammetry. For this purpose, a compromise had to be found in the heat treatment parameters in order to be able to treat both materials together. In addition, additively manufactured and rolled samples were investigated and used as a reference. Interaction of the two materials in the multi-material could be demonstrated, but further investigations are necessary to clearly assess the behaviour. In particular, the transition region of the two materials should be investigated. In this study, a stress relief heat treatment at 400 °C caused a slight improvement in the corrosion resistance and reduced the scatter of the measurements significantly. No significant difference was measured between the additively produced and rolled samples.
Development of Metallo (Calcium/Magnesium) Polyurethane Nanocomposites for Anti-Corrosive Applications
Authors: Alam Manawwer , Altaf Mohammad , Ahmed Mukhtar , Shaik Mohammed Rafi , Wahab Rizwan , Shaik Jilani Purusottapatnam , Samdani Mohammad Shahzad , Ahmad Ashfaq
Published: November 2022

Long-term corrosion protection of metals might be provided by nanocomposite coatings having synergistic qualities. In this perspective, rapeseed oil-based polyurethane (ROPU) and nanocomposites with calcium and magnesium ions were designed. The structure of these nanocomposites was established through Fourier-transform infrared spectroscopy (FT-IR). The morphological studies were carried out using scanning electron microscopy (SEM) as well as transmission electron microscopy (TEM). Their thermal characteristics were studied using thermogravimetric analysis (TGA). Electrochemical experiments were applied for the assessment of the corrosion inhibition performance of these coatings in 3.5 wt. % NaCl solution for 7 days. After completion of the test, the results revealed a very low icorr value of 7.73 × 10−10 A cm−2, a low corrosion rate of 8.342 × 10−5 mpy, impedance 1.0 × 107 Ω cm2, and phase angle (approx 90°). These findings demonstrated that nanocomposite coatings outperformed ordinary ROPU and other published methods in terms of anticorrosive activity. The excellent anti-corrosive characteristic of the suggested nanocomposite coatings opens up new possibilities for the creation of advanced high-performance coatings for a variety of metal industries.
Silver Itaconate as Single-Source Precursor of Nanocomposites for the Analysis of Chloride Ions
Authors: Kolesnikova Tatiana S. , Zarubina Anastasiya O. , Gorbunova Marina O. , Zhinzhilo Vladimir A. , Dzhardimalieva Gulzhian I. , Uflyand Igor E.
Published: November 2022

At present, conjugated thermolysis of metal-containing monomers is widely used as single-source precursors to obtain new metal- and metal oxide-containing nanocomposites. In this study, a detailed analysis of the main stages of conjugated thermolysis of silver itaconate was carried out. The obtained nanocomposites containing silver nanoparticles are evenly distributed in a stabilizing carbon matrix. The structural characteristics and properties of the resulting nanomaterials were studied using X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS). We have developed a method of test analysis of chlorides using paper modified with the obtained silver-containing nanocomposites. The analysis technique is based on the in situ conversion of chlorides to molecular chlorine, its dynamic release, and colorimetric detection using NP-modified paper test strips. A simple installation device is described that allows this combination to be realized. The proposed approach seems promising for nanoparticle-based determinations of other analytes that can be converted into volatile derivatives.
An Omnidirectional Dual-Functional Metasurface with Ultrathin Thickness
Authors: Xiong Ying , Liu Xiaoyi , Wang Kai , Wang Xiaokun , Wang Xiaoyi , Gao Jinsong , Yang Haigui
Published: November 2022

Although metasurfaces have received enormous attention and are widely applied in various fields, the realization of multiple functions using a single metasurface is still rarely reported to date. In this work, we propose a novel dual-functional metasurface that can be applied as a mid-infrared narrowband thermal light source in optical gas sensing and a long-wave infrared broadband absorber in photodetection. By actively tailoring the structure and constituent materials of the metasurface, the device yields an absorptivity of over 90% from 8 µm to 14 µm, while it exhibits an emissivity of 97.4% at the center wavelength of 3.56 μm with a full width at half-maximum of 0.41 µm. Notably, the metasurface is insensitive to the incident angle under both TM- and TE-polarized light. The proposed dual-functional metasurface possesses many advantages, including a simple structure, thin thickness, angle and polarization insensitivity, and compatibility with optical devices, which are expected to simplify the existing imaging systems and improve the performance of photodetection equipment.
Digital Image Correlation and Finite Element Computation to Reveal Mechanical Anisotropy in 3D Printing of Polymers
Authors: Guessasma Sofiane , Nouri Hedi , Belhabib Sofiane
Published: November 2022

In this study, we propose to revisit the mechanical anisotropy inferred to printed ABS polymers using fused deposition modelling by combining digital image correlation (DIC), mechanical testing and finite element computation. Tensile specimens are printed using different design orientations and raster angles. Monitoring of deformed samples is performed, and strain fields are derived for each configuration. Finite element modelling of the 3D-printed material behaviour is considered to shed more light on deformation mechanisms. Experimental results show that a heterogeneous strain field develops, leading to more significant strain localisation for samples printed with the main dimension aligned with the building direction. The optimal printing angle allowing the filament to be crossed at −45°/+45° shows the best behaviour with even larger elongation at break compared to the raw material. However, digital image correlation based on optical imaging shows that a limiting scale exists for revealing the effect of filament orientation on strain localisation. Finite element results reveal the nature of the strain localisation as related presence of porosity close to the frame and the development of asymmetrical filling within the printed structure.
Influence of Irradiation Parameters on Structure and Properties of Oak Wood Surface Engraved with a CO2 Laser
Authors: Kúdela Jozef , Kubovský Ivan , Andrejko Michal
Published: November 2022

The work investigates the effects of CO2 laser parameters (laser power and raster density) on wood mass loss in oak wood and impacts on its morphology, chemical structure, and surface properties (colour and hydrophilicity). The energy amount supplied onto the wood surface with a laser beam under different combinations of the irradiation parameters was expressed through a single variable—total irradiation dose. The mass loss was confirmed as linear-dependent on the irradiation dose. With the mass reduction, the roughness was enhanced. The roughness parameters Ra and Rz increased linearly with the mass loss associated with the increasing irradiation dose. The FTIR (Fourier transform infrared spectroscopy) spectroscopy also detected chemical changes in the main wood components, influencing primarily the wood colour space. Conspicuous discolouration of the engraved wood surface was observed, occurring just at the minimum laser power and raster density. The additional increasing of laser parameters caused a novel colour compared to the original one. The detected dependence of wood discolouration on the total irradiation dose enables us to perform targeted discolouration of the oak wood. The engraved surfaces manifested significantly better wettability with standard liquids, both polar and non-polar, and higher surface energy values. This guarantees appropriate adhesion of film-forming materials to wood. Identification of the changes in wood surface structure and properties, induced by specific CO2 laser-treatments, is important for obtaining targeted discolouration of the wood surface as well as for the gluing or finishing of the surfaces treated in this way.
Effects of High-Temperature Annealing Atmosphere on the Secondary Recrystallization Behavior and Magnetic Properties of Fe-3.2%Si-0.055%Nb Grain-Oriented Silicon Steel
Authors: Wang Liguang , Wang Shuhuan , Li Jie , Zhang Minghe , Feng Yunli
Published: November 2022

High-temperature annealing is a key step for the secondary recrystallization of grain-oriented silicon steel, which has an important effect on the final sharp Goss texture. In this work, the effects of three different annealing atmospheres during high-temperature annealing (100%H2, 25%N2 + 75%H2 and 50%N2 + 50%H2) on the secondary recrystallization microstructure and texture of Fe-3.2%Si-0.055%Nb low temperature grain-oriented silicon steel were analyzed by optical microscopy (OM) and electron back-scattered diffraction (EBSD) techniques, and the magnetic properties of the samples were compared. The results show that when the high-temperature annealing atmosphere is 100%H2, the texture of the grains with secondary recrystallization is mainly <110>//ND orientation, but the grains without secondary recrystallization have a disordered orientation. When the high-temperature annealing atmosphere is 50%H2 + 50%N2, the secondary recrystallization grains present a Goss texture and brass texture. After high-temperature annealing in the 25%N2 + 75%H2 atmosphere, the sample can be fully recrystallized to obtain secondary recrystallization grains; the grain size is relatively uniform and the texture is mainly a Goss texture with a sharp edge. The content of this reaches 93.1%, the magnetic induction B800 is the highest, reaching 1.89 T, and the iron loss P1.7/50 is the lowest, reaching 1.33 W/kg.
Experimental Investigations into the Pyrolysis Mechanism and Composition of Ceramic Precursors Containing Boron and Nitrides with Different Boron Contents
Authors: Hong Yiqiang , Qu Guoxin , Du Youpei , Yuan Tingting , Hao Shuangshuang , Yang Wei , Dai Zhen , Ma Qingsong
Published: November 2022

In this work, a novel ceramic precursor containing boron, silicon, and nitrides (named SiBCN) was synthesized from liquid ceramic precursors. Additionally, its pyrolysis, microstructure, and chemical composition were studied at 1600 °C. The results showed that the samples with different boron contents had similar structural composition, and both of the two precursors had stable amorphous SiBN structures at 1400 °C, which were mainly composed of B-N and Si-N and endowed them with excellent thermo-oxidative stability. With the progress of the heating process, the boron contents increased and the structures became more amorphous, significantly improving the thermal stability of the samples in high-temperature environments. However, during the moisture treatment, the introduction of more boron led to worse moisture stability.
Numerical Investigation of the Influence of Aerodynamic Loads on the Resonant Frequency of a Compressor Blade Made of EI-961 Alloy
Authors: Bednarz Arkadiusz , Puchała Krzysztof , Sałaciński Michał , Hutsaylyuk Volodymyr
Published: November 2022

The aim of this work was to numerically determine the influence of aerodynamic loads on the value of the resonant frequency of the compressor blade. The object of the research was the 1st stage compressor blade of the PZL-10W engine. As part of the research, analytical calculations of the resonance frequency were performed and compared with the literature ones (first, second, and third forms of forced vibrations). In the next step of the investigation, a computational model of the compressor stage (fluid domain and rotors) was built and FSI analysis was performed. This analysis was based on CFD modeling of the state of aerodynamic loads on the blade surfaces, and then these values were imported as external loads for the structural analysis, which was the basis for the modal analysis, in which the resonant frequency of the first three vibration modes was determined. As part of the analyzes, both the influence of aerodynamic loads and the rotational speed of the compressor rotor were verified. Thus, it was possible to evaluate the influence of both the rotational speed (and the arising centrifugal force) and the influence of the emerging aerodynamic load. The results obtained will allow for the assessment of the impact of the aforementioned operating conditions of the aircraft engine on the resonance frequency, which in turn may translate into the durability of critical components of the aircraft engine.
Novel 3D Printing Phase Change Aggregate Concrete: Mechanical and Thermal Properties Analysis
Authors: Jiang Jinyang , Zheng Chaolang , Wang Fengjuan , Xu Wenxiang , Wang Liguo , Chen Zhaoyi , Su Wei
Published: November 2022

The use of phase change materials (PCMs) in concrete is a double-edged sword that improves the thermal inertia but degrades the mechanical properties of concrete. It has been an essential but unsolved issue to enhance the thermal capacity of PCMs while non-decreasing their mechanical strength. To this end, this work designs a novel 3D printing phase change aggregate to prepare concrete with prominent thermal capacity and ductility. The work investigated the effects of 3D printing phase change aggregate on the compressive strength and splitting tensile strength of concrete. The compressive strength of phase change aggregate concrete is 21.18 MPa, but the ductility of concrete improves. The splitting tensile strength was 1.45 MPa. The peak strain is 11.69 × 10−3, nearly 13 times that of basalt aggregate concrete. Moreover, using 3D printing phase change aggregate reduced concrete’s early peak hydration temperature by 7.1%. The thermal insulation capacity of the experiment cube model with phase change concrete has been improved. The results show that the novel 3D printing change aggregate concrete has good mechanical properties and latent heat storage, providing a guideline for applying PCMs in building materials.
Chemical Constituents of the Deep-Sea-Derived Penicillium citreonigrum MCCC 3A00169 and Their Antiproliferative Effects
Authors: Zou Zheng-Biao , Zhang Gang , Zhou Yu-Qi , Xie Chun-Lan , Xie Ming-Min , Xu Lin , Hao You-Jia , Luo Lian-Zhong , Zhang Xiao-Kun , Yang Xian-Wen , Wang Jun-Song
Published: November 2022

Six new citreoviridins (citreoviridins J–O, 1–6) and twenty-two known compounds (7–28) were isolated from the deep-sea-derived Penicillium citreonigrum MCCC 3A00169. The structures of the new compounds were determined by spectroscopic methods, including the HRESIMS, NMR, ECD calculations, and dimolybdenum tetraacetate-induced CD (ICD) experiments. Citreoviridins J−O (1–6) are diastereomers of 6,7-epoxycitreoviridin with different chiral centers at C-2–C-7. Pyrenocine A (7), terrein (14), and citreoviridin (20) significantly induced apoptosis for HeLa cells with IC50 values of 5.4 μM, 11.3 μM, and 0.7 μM, respectively. To be specific, pyrenocine A could induce S phase arrest, while terrein and citreoviridin could obviously induce G0-G1 phase arrest. Citreoviridin could inhibit mTOR activity in HeLa cells.
The Optimized Conformation Dynamics of the KcsA Filter as a Probe for Lateral Membrane Effects: A First Principle Based Femto-Sec Resolution MD Study
Authors: Summhammer Johann , Sulyok Georg , Bernroider Gustav , Cocchi Massimo
Published: November 2022

We provide a high resolution, all-atom, femto-second molecular dynamics (MD) simulation of the passage of K+ ions and H2O molecules through the selectivity filter of the KcsA potassium ion channel, based on first principle physical methods. Our results show that a change in the length of the selectivity filter of as little as 3%, regardless of whether the filter is made longer or shorter, will reduce the K+ ion current by around 50%. In addition, further squeezing or stretching by about 9% can effectively stop the current. Our results demonstrate optimized conformational dynamics that associate an increased mobility of parts in the filter linings with a standard configuration, leading to maximized conduction rates that are highly sensitive to geometrical distortions. We discuss this latter aspect in relation to lateral membrane effects on the filter region of ion channels and the ‘force from lipids’ hypothesis.
Influence of Relative Humidity and Oxygen Concentration on Corrosion Behaviour of Copper in H2S-Containing Liquid Petroleum Gas
Authors: Li Xianqiang , Lu Yuan , Wei Qiang , Wang Hu , Xie Juan
Published: November 2022

In this paper, the influences of relative humidity (RH) and concentration of O2 on copper corrosion in H2S-containing LPG (liquid petroleum gas) were studied. The corrosion products obtained in different environments were also analysed by scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), grazing incidence X-ray diffraction (GIXRD), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). In H2S-containing LPG, RH has pronounced influence on the corrosion grade of copper. The variation in the critical point (CP) with the RH of LPG is a linear relationship. The presence of O2 in dry H2S has limited influence on the corrosion of copper. In the presence of different RHs, the CP always follows a negative exponential function with O2 concentration. The analysis of different corrosion products implies different corrosion behaviours and mechanisms, which are dependent on the presence or absence of water vapour. The corrosion mechanisms obtained in four different environments were also proposed.
Microstructure and Compressive Properties of Porous 2024Al-Al3Zr Composites
Authors: Zhang Wenchang , Xu Kun , Long Wei , Zhou Xiaoping
Published: November 2022

Porous 2024Al-Al3Zr composites were prepared by in situ and spatial scaffolding methods. As the Al3Zr content increased from 5 wt.% to 30 wt.%, the binding of the powder in the pore wall increased and the defects in the composites decreased. The yield strength of the composites reached 28.11 MPa and the energy absorption capacity was 11.68 MJ/m3 at a Zr content of 20 wt.%, when the composites had the best compression and energy absorption performance. As the space scaffold content increased from 50% to 70%, the porosity of the composites then increased from 53.51% to 70.70%, but the apparent density gradually decreased from 1.46 g/cm3 to 0.92 g/cm3, leading to a gradual decrease in their compressive properties. In addition, by analysing the compression fracture morphology, the increase of Al3Zr will reduce the stress concentration and hinder the crack growth, while too much Al3Zr will lead to brittleness and reduce the performance.
GlycA, a Biomarker of Low-Grade Inflammation, Is Increased in Male Night Shift Workers
Authors: Bizzarri Daniele , Dollé Martijn E. T. , Loef Bette , van den Akker Erik B. , van Kerkhof Linda W. M.
Published: November 2022

Sustained night shift work is associated with various adverse health risks, including an increased risk of cardiovascular disease, type II diabetes, and susceptibility to infectious respiratory diseases. The extent of these adverse health effects, however, seems to greatly vary between night shift workers, yet the underlying reasons and the mechanisms underlying these interindividual differences remain poorly understood. Metabolomics assays in the blood have recently gained much attention as a minimally invasive biomarker platform capturing information predictive of metabolic and cardiovascular diseases. In this cross-sectional study, we explored and compared the metabolic profiles of 1010 night shift workers and 1010 age- and sex-matched day workers (non-shift workers) from the Lifelines Cohort Study. The metabolic profiles were determined using the 1H-NMR Nightingale platform for the quantification of 250 parameters of metabolism, including routine lipids, extensive lipoprotein subclasses, fatty acid composition, and various low-molecular metabolites, including amino acids, ketone bodies, and gluconeogenesis-related metabolites. Night shift workers had an increased BMI (26.6 vs. 25.9 kg/m2) compared with day workers (non-shift workers) in both sexes, were slightly more likely to be ever smokers (only in males) (54% vs. 46%), worked on average 5.9 ± 3.7 night shifts per month, and had been working in night shifts for 18.3 ± 10.5 years on average. We observed changes in several metabolic markers in male night shift workers compared with non-shift workers, but no changes were observed in women. In men, we observed higher levels of glycoprotein acetyls (GlycA), triglycerides, and fatty acids compared with non-shift workers. The changes were seen in the ratio of triglycerides and cholesterol(esters) to total lipids in different sizes of VLDL particles. Glycoprotein acetyls (GlycAs) are of particular interest as markers since they are known as biomarkers for low-grade chronic inflammation. When the analyses were adjusted for BMI, no significant associations were observed. Further studies are needed to better understand the relationship between night shift work and metabolic profiles, particularly with respect to the role of sex and BMI in this relationship.
Origin of Ferroelectricity in BiFeO3-Based Solid Solutions
Authors: Noguchi Yuji , Matsuo Hiroki
Published: November 2022

We investigate the origin of ferroelectricity in the BiFeO3–LaFeO3 system in rhombohedral R3c and tetragonal P4mm symmetries by ab initio density functional theory calculations and compare their electronic features with paraelectric orthorhombic Pnma symmetry. We show that a coherent accommodation of stereo-active lone pair electrons of Bi is the detrimental factor of ferroelectricity. A Bloch function arising from an indirect Bi_6p–Fe_3d hybridization mediated through O_2p is the primary origin of spontaneous polarization (Ps) in the rhombohedral system. In the orthorhombic system, a similar Bloch function was found, whereas a staggered accommodation of stereo-active lone pair electrons of Bi exclusively results in paraelectricity. A giant Ps reported in the tetragonal system originates from an orbital hybridization of Bi_6p and O_2p, where Fe-3d plays a minor role. The Ps in the rhombohedral system decreases with increasing La content, while that in the tetragonal system displays a discontinuous drop at a certain La content. We discuss the electronic factors affecting the Ps evolutions with La content.
N-Heterocyclic Carbene Silver Complex Modified Polyacrylonitrile Fiber/MIL-101(Cr) Composite as Efficient Chiral Catalyst for Three-Component Coupling Reaction
Authors: Xin Ningning , Jing Xuemin , Zhang Cheng-Gen , Peng Xiaoxia , Liu Jing , Wang Qixing , Wang Wei , Cao Jian , Tao Minli
Published: November 2022

Complex asymmetric synthesis can be realized by the chiral induction of amino acids in nature. It is of great significance to design a new biomimetic catalytic system for asymmetric synthesis. In this context, we report the preparation and characterization of the composite of polyacrylonitrile fiber (PANF) and metal-organic framework to catalyze the chiral synthesis of propargylamines. A confined microenvironment is established with N-heterocyclic carbene (NHC) silver complex-supported PANF and D-proline-encapsulated MIL-101(Cr). This novel supported catalyst demonstrated high activity in addition to excellent stereoselectivity in the three-component reaction between alkynes, aldehydes, and amines (A3). The regeneration can be realized by adsorption of D-proline again when the stereoselectivity decreases after recycle uses. By regulating the confined microenvironment on the composite, the activity and selectivity of the catalytic system are improved with turnover numbers of up to 2800 and 98% ee. The biomimetic catalytic system to A3 coupling reaction is systematically studied, and the synergistic catalytic mechanism between NHC-Ag and D-proline in the confined microenvironment is revealed.
Rotating Hybrid Nanofluid Flow with Chemical Reaction and Thermal Radiation between Parallel Plates
Authors: Arshad Mubashar , Hassan Ali , Haider Qusain , Alharbi Fahad M. , Alsubaie Najah , Alhushaybari Abdullah , Burduhos-Nergis Diana-Petronela , Galal Ahmed M.
Published: November 2022

This research investigates the two different hybrid nanofluid flows between two parallel plates placed at two different heights, y0 and yh, respectively. Water-based hybrid nanofluids are obtained by using Al2O3, TiO2 and Cu as nanoparticles, respectively. The upper-level plate is fixed, while the lower-level plate is stretchable. The fluid rotates along the y-axis. The governing equations of momentum, energy and concentration are transformed into partial differential equations by using similarity transformations. These transformed equations are grasped numerically at MATLAB by using the boundary value problem technique. The influence of different parameters are presented through graphs. The numerical outcomes for rotation, Nusselt, Prandtl, and Schmidt numbers are obtained in the form of tables. The heat transfer rate increases by augmentation in the thermophoresis parameter, while it decays by increasing the Reynolds number. Oxide nanoparticles hybrid nanofluid proved more efficient as compared to mixed nanoparticles hybrid nanofluid. This research suggests using oxide nanoparticles for good heat transfer.
The Associations between Maternal Serum Aspartame and Sucralose and Metabolic Health during Pregnancy
Authors: Liu Yu , Li Xiaoyong , Wu Yiming , Su Qing , Qin Li , Ma Jing
Published: November 2022

Objective: We aimed to investigate the associations between maternal serum aspartame/sucralose levels and metabolic health during pregnancy. Methods: A nested population-based case-control study was conducted in 109 women with and without gestational diabetes mellitus (GDM). Serum aspartame and sucralose levels were assessed using an ultraperformance liquid chromatography coupled to a tandem mass spectrometry system. Results: We detected the presence of circulating aspartame and sucralose in all participants at fasting. No differences in serum aspartame or sucralose levels were observed between GDM and non-GDM groups. In the fully-adjusted linear regression models, serum aspartame levels were positively associated with insulin resistance index, total cholesterol, and LDL cholesterol. In the fully-adjusted logistic regression models, higher serum aspartame levels were positively associated with elevated HbA1c, insulin resistance, hypercholesterolemia, and hyper-LDL cholesterolemia. In the GDM group, the significant associations between higher serum aspartame levels and elevated HbA1c, insulin resistance, and hypo-HDL cholesterolemia persisted, while positive associations were found between higher serum aspartame levels and insulin resistance and hyper-LDL cholesterolemia in the non-GDM group. Serum sucralose levels were negatively associated with HbA1c. Conclusions: The study found that maternal serum aspartame levels were positively associated with insulin resistance index, total cholesterol, and LDL cholesterol during pregnancy. This finding provides the different effects of specific NNS on metabolic health during pregnancy.
The Impact of Job-Demand-Control-Support on Leptin and Ghrelin as Biomarkers of Stress in Emergency Healthcare Workers
Authors: Bouillon-Minois Jean-Baptiste , Outrey Justin , Pereira Bruno , Adeyemi Oluwaseun John , Sapin Vincent , Bouvier Damien , Thivel David , de Saint-Vincent Sarah , Ugbolue Ukadike Chris , Baker Julien S. , Bagheri Reza , Schmidt Jeannot , Trousselard Marion , Dutheil Frédéric
Published: November 2022

Despite the available literature on the consequences of night shiftwork on stress and food intake, its impact on leptin and ghrelin has never been studied. We previously demonstrated that leptin and ghrelin were biomarkers related to stress, and acute stress-induced a decrease in leptin levels and an increase in ghrelin levels. We performed a prospective observational study to assess the influence of night work, nutrition, and stress on the levels of ghrelin and leptin among emergency healthcare workers (HCWs). We took salivary samples at the beginning of a day shift and/or at the end of a night shift. We also monitored stress using the job demand-control-support model of Karasek. We recorded 24-h food intake during the day shift and the consecutive night shift and during night work and the day before. We included 161 emergency HCWs. Emergency HCWs had a tendency for decreased levels of leptin following the night shift compared to before the dayshift (p = 0.067). Furthermore, the main factors explaining the decrease in leptin levels were an increase in job-demand (coefficient −54.1, 95 CI −99.0 to −0.92) and a decrease in job control (−24.9, −49.5 to −0.29). Despite no significant changes in ghrelin levels between shifts, social support was the main factor explaining the increase in ghrelin (6.12, 0.74 to 11.5). Food intake (kcal) also had a negative impact on leptin levels, in addition to age. Ghrelin levels also decreased with body mass index, while age had the opposite effect. In conclusion, we confirmed that ghrelin and leptin as biomarkers of stress were directly linked to the job demand-control-support model of Karasek, when the main cofounders were considered.
Assessment of Nutritional Quality of Products Sold in University Vending Machines According to the Front-of-Pack (FoP) Guide
Authors: Lasala Carmen , Durán Antonio , Lledó Daniel , Soriano Jose
Published: November 2022

The aim of this research was to assess the nutritional composition of 654 foods and beverages from vending machines on a University Campus. The guide called “Creating a front of pack nutrition label for pre-packed products sold through retail outlets” from the Department of Health (UK) was used to assess the nutritional composition and to compare values from food and beverage categories. A high proportion of food items had high–moderate content of nutrients related to chronic disease (93, 88, 74 and 49% had high–moderate content of fat, saturated fat, salt and sugar, respectively). On the other hand, a few beverages had high–moderate content of these nutrients, except for sugar (2% high to moderate in fat, 2% in saturated fat, 0% in salt and 39% in sugar). The most frequent food categories were chocolates and bars (10.6%) and breadsticks (8.4%), whereas the most available beverages were water (27.7%) and soft drinks (23.4%). There were no statistically significant differences in the proportion of categories between the health science and humanities faculties, except for energy drinks (p < 0.05) and soft drinks (p < 0.05). Vending machines contribute to an obesogenic environment and do not support healthy snacking. Recommendations in this article should be considered to develop official guidelines to ensure the wider availability of healthy dietary choices in vending machines in university settings.
Impact of Impulsivity and Therapy Response in Eating Disorders from a Neurophysiological, Personality and Cognitive Perspective
Authors: Testa Giulia , Granero Roser , Misiolek Alejandra , Vintró-Alcaraz Cristina , Mallorqui-Bagué Núria , Lozano-Madrid Maria , Heras Misericordia Veciana De Las , Sánchez Isabel , Jiménez-Murcia Susana , Fernández-Aranda Fernando
Published: November 2022

Impulsivity, as a multidimensional construct, has been linked to eating disorders (EDs) and may negatively impact treatment response. The study aimed to identify the dimensions of impulsivity predicting poor remission of ED symptoms. A total of 37 ED patients underwent a baseline assessment of impulsive personality traits and inhibitory control, including the Stroop task and the emotional go/no-go task with event-related potentials (ERPs) analysis. The remission of EDs symptomatology was evaluated after 3 months of cognitive-behavioral therapy (CBT) and at a 2-year follow-up. Poor remission after CBT was predicted by poor inhibitory control, as measured by the Stroop task. At 2 years, the risk of poor remission was higher in patients with higher novelty seeking, lower inhibitory control in the Stroop and in ERPs indices (N2 amplitudes) during the emotional go/no-go task. The present results highlight inhibitory control negatively impacting both short- and long-term symptomatology remission in ED patients. On the other hand, high novelty seeking and ERPs indices of poor inhibition seem to be more specifically related to long-term remission. Therefore, a comprehensive assessment of the impulsivity dimension in patients with ED is recommended to tailor treatments and improve their efficacy.
Halting the Metabolic Complications of Antipsychotic Medication in Patients with a First Episode of Psychosis: How Far Can We Go with the Mediterranean Diet? A Pilot Study
Authors: Ntalkitsi Savina , Efthymiou Dimitris , Bozikas Vasilios , Vassilopoulou Emilia
Published: November 2022

Patients with first-episode psychosis (FEP) often adopt unhealthy dietary patterns, with a risk of weight gain and metabolic and cardiovascular disease. In 21 FEP patients receiving nutritional intervention based on the Mediterranean diet (MedDiet), we explored differences in anthropometric and biometric parameters, according to their antipsychotic (AP) medication: AP1, associated with a lower risk, or AP2, associated with a higher risk of weight gain and metabolic complications. The blood biochemical profile was recorded before and after dietary intervention, and dietary habits and body composition were monitored for six months. Following intervention, all of the patients recorded significant increases in the consumption of fruit and vegetables and decreases in red meat and poultry consumption, with closer adherence to the MedDiet and a reduction in the daily intake of calories, carbohydrates, and sodium. Vegetable consumption and energy, protein, and carbohydrate intake were lower in AP1 patients than in AP2 patients. There was no significant weight gain overall. A reduction was demonstrated in total and LDL cholesterol, sodium, urea, and iron (lower in AP1 patients). It was evident that AP medication affected blood levels of lipids, urea, and iron of FEP patients, but MedDiet nutritional intervention led to a significant improvement in their eating habits, with a restriction in weight gain and a decrease in blood sodium and urea.
Boosting Tadalafil Bioavailability via Sono-Assisted Nano-Emulsion-Based Oral Jellies: Box–Behnken Optimization and Assessment
Authors: Ali Hany S. M. , Ahmed Sameh A. , Alqurshi Abdulmalik A. , Alalawi Ali M. , Shehata Ahmed M. , Alahmadi Yaser M.
Published: November 2022

Tadalafil (TAD) is a poorly soluble, phosphodiesterase inhibitor used to treat erectile dysfunction. The primary goal of this project was to prepare nano-emulsions using ultrasonic technology to address TAD bioavailability concerns. The Box–Behnken design was employed to find prominent correlations between factors impacting the sono-emulsification process. The emulsifier concentration, amplitude level, and ultrasonication time were the independent factors, whereas the average droplet size (ADS) and polydispersity index (PDI) were designated as the response variables. TAD-loaded nano-emulsions (93–289 nm) were generated and the emulsifier concentration showed a crucial role in directing emulsion droplet size. The model desirability function was utilized to optimize a nano-emulsion with a small ADS (99.67 ± 7.55 nm) and PDI (0.45 ± 0.04) by adjusting the emulsifiers concentration, amplitude level, and ultrasonication time at 9.85%, 33%, 49 s, respectively. The optimized nano-emulsions did not demonstrate any precipitation or phase separation after stability stress tests. TAD jellies were formulated based on the optimized nano-emulsion and subjected to in vitro evaluation for physical characteristics; TAD content, pH, spreadability, viscosity, syneresis, and taste-masking ability. An optimized nano-emulsion-based jelly (NEJ) formulation showed more than 96% drug dissolution in 30 min relative to 14% for the unprocessed TAD. In vivo assessment of NEJ in experimental rats demonstrated a significant enhancement (p < 0.05) of TAD bioavailability with an AUC0–24h of 2045 ± 70.2 vs. 259.9 ± 17.7 ng·h·mL−1 for the unprocessed TAD. Storage stability results revealed that NEJ remained stable with unremarkable changes in properties for 3 months. Overall, NEJ can be regarded as a successful therapeutic option for TAD administration with immediate-release properties and improved bioavailability.
Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo
Authors: Zhang Yu , Vagiannis Dimitrios , Budagaga Youssif , Sabet Ziba , Hanke Ivo , Rozkoš Tomáš , Hofman Jakub
Published: November 2022

Encorafenib (LGX818, trade name Braftovi), a novel BRAF inhibitor, has been approved for the treatment of melanoma and colorectal cancer. In the present work, we evaluated encorafenib’s possible antagonistic effects on the pharmacokinetic mechanisms of multidrug resistance (MDR), as well as its perpetrator role in drug interactions. Firstly, encorafenib potently inhibited the efflux function of the ABCC1 transporter in drug accumulation assays, while moderate and null interaction levels were recorded for ABCB1 and ABCG2, respectively. In contrast, the mRNA expression levels of all the tested transporters were not altered by encorafenib. In the drug combination studies, we found that daunorubicin and topotecan resistances were synergistically attenuated by the encorafenib-mediated interaction in A431-ABCC1 cells. Notably, further experiments in ex vivo patient-derived explants confirmed the MDR-modulating ability of encorafenib. Advantageously, the overexpression of tested drug efflux transporters failed to hinder the antiproliferative activity of encorafenib. In addition, no significant modulation of the CYP3A4 enzyme’s activity by encorafenib was observed. In conclusion, our work indicated that encorafenib can act as an effective chemosensitizer targeting the ABCC1-induced MDR. Our in vitro and ex vivo data might provide valuable information for designing the novel effective scheme applicable in the clinical pharmacotherapy of BRAF-mutated/ABCC1-expressing tumors.
Involvement of Bacterial Extracellular Membrane Nanovesicles in Infectious Diseases and Their Application in Medicine
Authors: Lusta Konstantin A. , Poznyak Anastasia V. , Litvinova Larisa , Poggio Paolo , Orekhov Alexander N. , Melnichenko Alexandra A.
Published: November 2022

Bacterial extracellular membrane nanovesicles (EMNs) are attracting the attention of scientists more and more every year. These formations are involved in the pathogenesis of numerous diseases, among which, of course, the leading role is occupied by infectious diseases, the causative agents of which are a range of Gram-positive and Gram-negative bacteria. A separate field for the study of the role of EMN is cancer. Extracellular membrane nanovesicles nowadays have a practical application as vaccine carriers for immunization against many infectious diseases. At present, the most essential point is their role in stimulating immune response to bacterial infections and tumor cells. The possibility of nanovesicles’ practical use in several disease treatments is being evaluated. In our review, we listed diseases, focusing on their multitude and diversity, for which EMNs are essential, and also considered in detail the possibilities of using EMNs in the therapy and prevention of various pathologies.