bluuebunny/crossref_metadata_2025 huggingface dataset:
AAV9-mediated functional screening for cardioprotective cytokines in Coxsackievirus-B3-induced myocarditis
Authors: Carai Paolo , Ruozi Giulia , Paye Alexandra , Debing Yannick , Bortolotti Francesca , Lecomte Julie , Zentilin Lorena , Jones Elizabeth A. V. , Giacca Mauro , Heymans Stephane
Published: May 2022

Viral myocarditis (VM) is an important cause of heart failure (HF) in children and adults. However, the molecular determinants involved in cardiac inflammation and cardiomyocyte necrosis remain poorly characterized, and cardioprotective molecules are currently missing. Here, we applied an in vivo method based on the functional selection (FunSel) of cardioprotective factors using AAV vectors for the unbiased identification of novel immunomodulatory molecules in a Coxsackievirus B3 (CVB3)-induced myocarditis mouse model. Two consecutive rounds of in vivo FunSel using an expression library of 60 cytokines were sufficient to identify five cardioprotective factors (IL9, IL3, IL4, IL13, IL15). The screening also revealed three cytokines (IL18, IL17b, and CCL11) that were counter-selected and likely to exert a detrimental effect. The pooled overexpression of the five most enriched cytokines using AAV9 vectors decreased inflammation and reduced cardiac dilatation, persisting at 1 month after treatment. Individual overexpression of IL9, the top ranking in our functional selection, markedly reduced cardiac inflammation and injury, concomitant with an increase of anti-inflammatory Th2-cells and a reduction of pro-inflammatory Th17- and Th22-cells at 14 days post-infection. AAV9-mediated FunSel cardiac screening identified IL9 and other four cytokines (IL3, IL4, IL13, and IL15) as cardioprotective factors in CVB3-induced VM in mice.
Innovative diagnostic device for thickness measurement of conveyor belts in horizontal transport
Authors: Kirjanów-Błażej Agata , Błażej Ryszard , Jurdziak Leszek , Kozłowski Tomasz , Rzeszowska Aleksandra
Published: May 2022

Diagnostics of conveyor belts used in horizontal transport without the need to take the belt off the conveyor and test it in laboratory conditions is an important aspect in mining plants (Jurdziak et al., Adv Intell Syst Comput, 835:645–654, 2019). Current testing, and thus obtaining knowledge about the current thickness of the conveyor belt covers, allows for control accelerated changes. It also avoids emergency stoppages in the operation of the conveyor and enables economically justified planning of a break in its operation. The article presents the concept of the first in Poland mobile device for measuring the thickness of conveyor belts in motion, implemented as part of the NCBR project (No. 0227 / L-10/2018 [LIDER program, Transport Przemysłowy i Maszyny Robocze, 1(47)/2020, pp. 60–61]), and also presents the measurement results obtained thanks to the laboratory version of the device.
A comprehensive atlas of Aggrecan, Versican, Neurocan and Phosphacan expression across time in wildtype retina and in retinal degeneration
Authors: Matsuyama A. , Kalargyrou A. A. , Smith A. J. , Ali R. R. , Pearson R. A.
Published: May 2022

As photoreceptor cells die during retinal degeneration, the surrounding microenvironment undergoes significant changes that are increasingly recognized to play a prominent role in determining the efficacy of therapeutic interventions. Chondroitin Sulphate Proteoglycans (CSPGs) are a major component of the extracellular matrix that have been shown to inhibit neuronal regrowth and regeneration in the brain and spinal cord, but comparatively little is known about their expression in retinal degeneration. Here we provide a comprehensive atlas of the expression patterns of four individual CSPGs in three models of inherited retinal degeneration andwildtypemice. Inwildtypemice, Aggrecan presented a biphasic expression, while Neurocan and Phosphacan expression declined dramatically with time and Versican expression remained broadly constant. In degeneration, Aggrecan expression increased markedly inAipl1-/-andPde6brd1/rd1, while Versican showed regional increases in the periphery ofRho-/-mice. Conversely, Neurocan and Phosphacan broadly decrease with time in all models. Our data reveal significant heterogeneity in the expression of individual CSPGs. Moreover, there are striking differences in the expression patterns of specific CSPGs in the diseased retina, compared with those reported following injury elsewhere in the CNS. Better understanding of the distinct distributions of individual CSPGs will contribute to creating more permissive microenvironments for neuro-regeneration and repair.
First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Authors: Gierse Robin M. , Oerlemans Rick , Reddem Eswar R. , Gawriljuk Victor O. , Alhayek Alaa , Baitinger Dominik , Jakobi Harald , Laber Bernd , Lange Gudrun , Hirsch Anna K. H. , Groves Matthew R.
Published: May 2022

The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most bacteria synthesize isoprenoid precursors through the MEP pathway. 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the first reaction of the MEP pathway and is an attractive target for the development of new antibiotics. We report here the successful use of a loop truncation to crystallize and solve the first DXPS structures of a pathogen, namely M. tuberculosis (MtDXPS). The main difference found to other DXPS structures is in the active site where a highly coordinated water was found, showing a new mechanism for the enamine-intermediate stabilization. Unlike other DXPS structures, a “fork-like” motif could be identified in the enamine structure, using a different residue for the interaction with the cofactor, potentially leading to a decrease in the stability of the intermediate. In addition, electron density suggesting a phosphate group could be found close to the active site, provides new evidence for the D-GAP binding site. These results provide the opportunity to improve or develop new inhibitors specific for MtDXPS through structure-based drug design.
Static and dynamic analyses of free-hinged-hinged-hinged-free beam in non-homogeneous gravitational field: application to gravity gradiometry
Authors: Veryaskin Alexey V. , Meyer Thomas J.
Published: May 2022

The first analytical evaluation of a free-hinged-hinged-hinged-free beam proposed for use as the primary sensing element of a new gravity gradiometer is presented. Results of the evaluation obtained in quadratures are applied to the beam’s structure, including locating the hinges that form the beam’s boundary conditions allowing only free rotations around its nodal axes. These are deliberately chosen to minimize the beam’s symmetric free ends deflections under the uniform body loading of gravity while simultaneously permitting the beam’s maximum possible mirror-symmetric free ends deflections owing to a gravity gradient distributed along its length. The flexible triple-hinged beam deformation from its nominal unloaded geometry is naturally elastically coupled throughout, including free ends, allowing synchronized mechanical displacement measurements at any deflection point. Some methods of manufacturing such sensing elements and their respective error mechanisms are also discussed and presented for the first time.
Pre-transplant infusion of donor leukocytes treated with extracorporeal photochemotherapy induces immune hypo-responsiveness and long-term allograft survival in murine models
Authors: Schneiderman Jennifer , Qiu Longhui , Yeap Xin Yi , Kang Xin , Zheng Feibo , Ye Junsheng , Xie Yan , Wang Jiao-Jing , Sambandam Yuvaraj , Mathew James , Li Lin , Leventhal Joseph , Edelson Richard L. , Zhang Zheng Jenny
Published: May 2022

Recipients of solid organ transplantation (SOT) rely on life-long immunosuppression (IS), which is associated with significant side effects. Extracorporeal photochemotherapy (ECP) is a safe, existing cellular therapy used to treat transplant rejection by modulating the recipient’s own blood cells. We sought to induce donor-specific hypo-responsiveness of SOT recipients by infusing ECP-treated donor leukocytes prior to transplant. To this end, we utilized major histocompatibility complex mismatched rodent models of allogeneic cardiac, liver, and kidney transplantation to test this novel strategy. Leukocytes isolated from donor-matched spleens for ECP treatment (ECP-DL) were infused into transplant recipients seven days prior to SOT. Pre-transplant infusion of ECP-DL without additional IS was associated with prolonged graft survival in all models. This innovative approach promoted the production of tolerogenic dendritic cells and regulatory T-cells with subsequent inhibition of T-cell priming and differentiation, along with a significant reduction of donor-specific T-cells in the spleen and grafts of treated animals. This new application of donor-type ECP-treated leukocytes provides insight into the mechanisms behind ECP-induced immunoregulation and holds significant promise in the prevention of graft rejection and reduction in need of global immune suppressive therapy in patients following SOT.
Evaluation of MxOy/fucoidan hybrid system and their application in lipase immobilization process
Authors: Kołodziejczak-Radzimska Agnieszka , Bielejewski Michał , Biadasz Andrzej , Jesionowski Teofil
Published: May 2022

In this work, new MxOy/fucoidan hybrid systems were fabricated and applied in lipase immobilization. Magnesium (MgO) and zirconium (ZrO2) oxides were used as MxOy inorganic matrices. In the first step, the proposed oxides were functionalized with fucoidan from Fucus vesiculosus (Fuc). The obtained MgO/Fuc and ZrO2/Fuc hybrids were characterized by means of spectroscopic analyses, including Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and nuclear magnetic resonance. Additionally, thermogravimetric analysis was performed to determine the thermal stability of the hybrids. Based on the results, the mechanism of interaction between the oxide supports and fucoidan was also determined. Furthermore, the fabricated MxOy/fucoidan hybrid materials were used as supports for the immobilization of lipase from Aspergillus niger, and a model reaction (transformation of p-nitrophenyl palmitate to p-nitrophenol) was performed to determine the catalytic activity of the proposed biocatalytic system. In that reaction, the immobilized lipase exhibited high apparent and specific activity (145.5 U/gcatalyst and 1.58 U/mgenzyme for lipase immobilized on MgO/Fuc; 144.0 U/gcatalyst and 2.03 U/mgenzyme for lipase immobilized on ZrO2/Fuc). The immobilization efficiency was also confirmed using spectroscopic analyses (FTIR and XPS) and confocal microscopy.
Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: a computed fluid dynamics analysis
Authors: Muraoka Shinsuke , Takagi Reiya , Araki Yoshio , Uda Kenji , Sumitomo Masaki , Okamoto Sho , Nishihori Masahiro , Izumi Takashi , Nakamura Masanori , Saito Ryuta
Published: May 2022

Balloon test occlusion (BTO) is an angiographic test to evaluate ischemic tolerance after permanent occlusion of an internal carotid artery (ICA). BTO can simulate ischemia caused by parent artery occlusion and can be used to select a suitable bypass surgery using specific criteria. On the other hand, a postoperative thrombus can form despite proper case selection, optimal radiological evaluation, and an appropriate surgical strategy. Postoperative ischemic complications related to perforating branches are clinically significant. This simulation study aimed to analyze postoperative flow characteristics and elucidate the cause of ischemic complications related to the perforating branch using computational fluid dynamics (CFD). An unexpected postoperative thrombus formation related to the perforating branch occurred after treating a giant aneurysm in the cavernous portion of the ICA in a patient. Three-dimensional digital subtraction angiography was used to acquire flow data and set up the CFD simulation. The flow simulations were performed at various bypass flow rates. The CFD analysis indicated flow stagnation in the ICA only when surgical treatment using a low-flow bypass graft was performed. Thrombus formation may lead to ischemic complications related to the perforating branch, such as the anterior choroidal artery. BTO did not reflect the influence of bypass blood flow. Therefore, recognizing that blood flow stagnation may occur and comprehensively deciding on the surgical strategy by CFD analysis can be helpful to prevent ischemic complications in patients with giant aneurysms.
Design of effective self-powered SnS2/halide perovskite photo-detection system based on triboelectric nanogenerator by regarding circuit impedance
Authors: Shooshtari Leyla , Ghods Soheil , Mohammadpour Raheleh , Esfandiar Ali , Iraji zad Azam
Published: May 2022

Self-powered detectors based on triboelectric nanogenerators (TENG) have been considered because of their capability to convert ambient mechanical energy to electrical out-put signal, instead of conventional usage of electrochemical batteries as power sources. In this regard, the self-powered photodetectors have been designed through totally two lay out called passive and active circuit. in former model, impedance matching between the TENG and the resistance of the circuit’s elements is crucial, which is not investigated systematically till now. In this paper, a cost effective novel planar photodetector (PD) based on heterojunction of SnS2 sheets and Cs0.05(FA0.83 MA0.17)0.95Pb(I0.83Br0.17)3 three cationic lead iodide based perovskite (PVK) layer fabricated which powered by graphene oxide (GO) paper and Kapton based contact-separated TENG (CS-TENG). To achieve the high performance of this device, the proper range of the load resistances in the circuit regards to TENG’s characterization has been studied. In the next steps, the integrated self-powered photo-detection system was designed by applying Kapton/FTO and hand/FTO TENG, separately, in the proposed impedance matching circuit. The calculated D* of integrated self-powered SnS2/PVK supplied by tapping the Kapton and hand on FTO is 2.83 × 1010 and 1.10 × 1013 Jones under the 10 mW/cm2 of white light intensity, the investigations determine that for designing significate performance of self-powered PD supplied by TENG, the existence of the load resistance with the well match amount to the utilized TENG is crucial. Our results which can be generalized to other types of passive self-powered sensors, are substantial to both academia and industry concepts.
A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species
Authors: Shahrivari Saba , Alizadeh Saeedeh , Ghassemi-Golezani Kazem , Aryakia Elyas
Published: May 2022

Artemisiais one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of threeArtemisiaspecies(A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC–MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster analysis grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed inA. khorassanicaandA. haussknechtiispecies, respectively. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-β-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher inA. tournefortianacollected from Kerman andA. haussknechtiicollected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded forA. haussknechtiicollected from Isfahan province. The highest flavonoids content was found inA. tournefortianacollected from West Azerbaijan andA. khorassanicacollected from North Khorasan. The highest FRAP antioxidant activity was observed inA. tournefortiana(Kerman) and the lower amount was inA. haussknechtiicollected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was inA. khorassanicacollected from South Khorasan and the lowest activity was in Isfahan'sA. haussknechtii.The acetycholine esterase inhibitory activity was higher inA. tournefortianacollected from West Azerbaijan; and the lowest activity was inA. haussknechtiicollected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was inA. khorassanicacollected from North Khorasan; and the lowest was inA. haussknechtiicollected from Chaharmahal and Bakhtiari.
Diagnostic accuracy of probe-based confocal laser endomicroscopy and tissue sampling by endoscopic retrograde cholangiopancreatography in indeterminate biliary strictures: a meta‑analysis
Authors: Mi Junjie , Han Xiaofang , Wang Rong , Ma Ruijun , Zhao Danyu
Published: May 2022

Probe-based confocal laser endomicroscopy (pCLE), also known as optical biopsy, is a new endoscopic technique that provides real-time magnification of 1000 × microscopic tissue information to diagnose indeterminate biliary strictures. Tissue sampling by endoscopic retrograde cholangiopancreatography (ERCP) is routinely performed to evaluate indeterminate biliary strictures. To evaluate the accuracy of pCLE and tissue sampling by ERCP in the diagnosis of indeterminate biliary strictures, 18 articles were included from 2008 to 2021 through Embase, PubMed, Web of Science, and Cochrane library databases. The summary estimates for the pCLE diagnosis of indeterminate biliary strictures were: sensitivity 0.88 (95% confidence interval (CI), 0.84–0.91); specificity 0.79 (95% CI 0.74–0.83); and Diagnostic Odds Ratio (DOR) 24.63 (95% CI 15.76–38.48). The summary estimates for tissue sampling by ERCP diagnosis for indeterminate biliary strictures were: sensitivity 0.54 (95% CI 0.49–0.59); specificity 0.96 (95% CI 0.94–0.98); and DOR 11.31 (95% CI 3.90–32.82). The area under the sROC curve of pCLE diagnosis of indeterminate biliary strictures is 0.90 higher than 0.65 of tissue sampling by ERCP. The pCLE is a better approach than tissue sampling by ERCP for the diagnosis of indeterminate biliary strictures by providing real-time microscopic images of the bile ducts.
12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation
Authors: Yang Gangqiang , Ishimaru Yasuhiro , Hoshino Shunji , Muraoka Yuki , Uozumi Nobuyuki , Ueda Minoru
Published: May 2022

Foliar nyctinasty, a circadian rhythmic movement in plants, is common among leguminous plants and has been widely studied. Biological studies on nyctinasty have been conducted using Samanea saman as a model plant. It has been shown that the circadian rhythmic potassium flux from/into motor cells triggers cell shrinking/swelling to cause nyctinastic leaf-folding/opening movement in S. saman. Recently, 12-hydroxyjasmonic acid glucoside (JAG) was identified as an endogenous chemical factor causing leaf-folding of S. saman. Additionally, SPORK2 was identified as an outward-rectifying potassium channel that causes leaf-movement in the same plant. However, the molecular mechanism linking JAG and SPORK2 remains elusive. Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S. saman, and this occurs independently of plant hormone signaling. Furthermore, we show that SPORK2 is indispensable for the JAG-triggered shrinkage of the motor cell. This is the first report on JAG, which is believed to be an inactivated/storage derivative of JA, acting as a bioactive metabolite in plant.
Fatigue: a frequent and biologically based phenomenon in newly diagnosed celiac disease
Authors: Skjellerudsveen Berit Mære , Omdal Roald , Hetta Anne Kristine , Kvaløy Jan Terje , Aabakken Lars , Skoie Inger Marie , Grimstad Tore
Published: May 2022

Fatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge is scarce, and opinions are conflicting. This study aimed to investigate the prevalence and severity of fatigue in patients with newly diagnosed celiac disease and compare it with healthy control subjects. Ninety patients with newly diagnosed celiac disease were compared with 90 age- and sex-matched healthy subjects. The primary endpoints were fatigue severity as measured by: the fatigue Visual Analog Scale (fVAS), the Fatigue Severity Scale (FSS), and the inverted Vitality subscale of the MOS36 (SF-36vs). Higher scores indicate more severe fatigue. Clinically relevant fatigue was determined using predefined cut-off values. Secondary endpoints were the associations between fatigue, and sex, age, depression, pain, and selected biochemical variables. The median (IQR) fVAS-scores were 43.0 (18.0–64.5) in patients, and 9.0 (2.0–16.0) in the control group (p < 0.001); and the FSS scores 3.8 (2.0–4.8) in patients, and 1.4 (1.0–1.9) in control subjects (p < 0.001). Inverted SF-36vs scores had a mean (SD) value of 58.8 (23.6) in patients, and 29.7 (14.3) in healthy subjects (p < 0.001). The presence of clinically relevant fatigue ranged from 41 to 50% in patients. Increased fatigue severity was associated with female sex, younger age, and elevated pain and depression scores, but not with levels of selected biochemical variables, including hemoglobin. Fatigue is a severe and frequent phenomenon in patients with untreated celiac disease.
Calcium Phosphate Invert Glasses
Authors: Lee Sungho
Published: May 2022

Phosphate invert glasses are composed of short phosphate groups and contain a large proportion of cations. Introducing intermediate oxides, such as TiO2, Nb2O5, ZnO, and MgO, to phosphate invert glasses can manipulate their properties via tailored manipulation of their glass network structures. TiO2, Nb2O5, and ZnO improve the chemical durability of phosphate invert glasses (i.e., reduce their ion-releasing ability), whereas MgO decreases their chemical durability (i.e., enhances their ion-releasing ability). Phosphate invert glasses can be tailored for various biomedical applications by manipulating their glass network structures to control their properties.
Phosphate-based Glasses Prepared via Sol–Gel and Coacervation
Authors: Carta Daniela , Pickup David M. , Foroutan Farzad
Published: May 2022

Phosphate-based glasses are a very promising class of multifunctional biomaterials. Being bioresorbable, they are capable of inducing simultaneous regeneration of tissue and delivery of drugs/therapeutic molecules and ions. Therefore, they can be used both as temporary implants and as controlled local delivery systems. Biomaterial-related infections, often causing revision surgery, could be prevented by incorporating into the biomaterial device antimicrobial agents that will be slowly released as the implant degrades. To date, the conventional technique used to prepare phosphate-based glasses is the melt-quenching process, which requires the melting of oxide powders at high temperatures (1000–1200 °C) followed by rapid cooling. However, this method often leads to non-homogeneous, bulk glasses that cannot be used for hosting temperature-sensitive molecules and can lead to reduction of antibacterial ions. Composition is also difficult to control because of the loss of volatile phosphate species during heating. This chapter describes two in-solution techniques for the synthesis of phosphate-based glasses alternative to the melt-quenching one: sol–gel and coacervation. A review of the literature published so far on the topics and a summary of key results is presented.
Structure and Properties of Borate Glasses
Authors: Topper Brian , Möncke Doris
Published: May 2022

The role of boron oxide in glass science is broad, spanning from borate glasses used as bioactive materials, sealing agents, dosimeters, and radiation shielding glasses, to an additive in chemically durable or nuclear-waste-immobilizing borosilicate glasses. The structure of borate glasses from pure boron oxide glass up to highly modified compositions is discussed in this chapter, covering the full range of borate chemical structures in glasses and melts. The boron anomaly, the conversion of trigonal borate units to tetrahedral borate units is introduced, and we outline the impact this has on the structure and properties of modified borate glasses. The factors influencing the equilibrium between three- and four-coordinated boron, such as modifier type and quantity, synthesis temperature, and the number of non-oxygen anions, are looked at to demonstrate the highly tuneable nature of borate glasses for diverse applications.
Formulation and Processing for Powder Sachets
Authors: Pitt Kendal
Published: May 2022

Powder-filled sachets and stick packs are a niche dosage form in the pharmaceutical industry. They are developed to cover several scenarios when an alternative to a solid dosage form such as a capsule or tablet is preferred and when a pre-made liquid preparation is not feasible, for example due to long-term stability issues. Key to the successful design and manufacture of these powder products is the understanding of the interplay between the formulation, the filling equipment and the packaging. Hence, it is vital to define the final manufacturing train and packaging presentation before commencing product development.
The antimicrobial effect of calcium-doped titanium is activated by fibrinogen adsorption
Authors: Cao Huiliang , Dauben Thomas J. , Helbing Christian , Jia Zhichao , Zhang Yuechao , Huang Moran , Müller Lenka , Gu Song , Zhang Xiaoyuan , Qin Hui , Martin Karin , Bossert Jörg , Jandt Klaus D.
Published: May 2022

Non-germicidal calcium doping is effective in exposing the antimicrobial action of human fibrinogen.
Halogenation of Li7La3Zr2O12 solid electrolytes: a combined solid-state NMR, computational and electrochemical study
Authors: Dong Bo , Haworth Abby R. , Yeandel Stephen R. , Stockham Mark P. , James Matthew S. , Xiu Jingwei , Wang Dawei , Goddard Pooja , Johnston Karen E. , Slater Peter R.
Published: May 2022

Tetragonal Li7La3Zr2O12 (LLZO) was halogenated to form cubic LLZOF(Cl) via a low temperature solid state synthetic route using PTFE and PVC polymers.
Fully handwritten electrodes on paper substrate using rollerball pen with silver nanoparticle ink, marker pen with carbon nanotube ink and graphite pencil
Authors: Ferreira de Oliveira Ana Elisa , César Pereira Arnaldo , Ferreira Lucas Franco
Published: May 2022

The so-called carbon nanotube electrode was printed on a paper using handwriting technique, carbon nanotube ink to print working electrode, graphite pencil for counter electrode and graphite/silver nanoparticle ink for quasi-reference electrode.
Mechanical behavior of biomimetic oriented cell sheets from a perspective of living materials
Authors: Xu Wei , Chen Shuangshuang , Yao Mengting , Lu Qinghua
Published: May 2022

Multiscale analyses of the mechanical behavior at tissue-, cellular- and subcellular-scales explain how cell sheets respond to the cell orientation and external stretching.
An injectable double network hydrogel with hemostasis and antibacterial activity for promoting multidrug-resistant bacteria infected wound healing
Authors: Zhang Zibo , Guo Jiadong , He Yuxiang , Han Jinzhi , Chen Mingmao , Zheng Yunquan , Zhang Shenghang , Guo Shaobin , Shi Xianai , Yang Jianmin
Published: May 2022

A double network hydrogel with injectability, hemostasis, and antibacterial activity was developed through dynamic Schiff-base chemistry and photopolymerization crosslinking. It can enhance MRSA-infected full-thickness skin defect wound healing.
Non-innocent redox behavior of CuII–p-dimethylaminophenolate complexes: formation and characterization of the CuI–phenoxyl radical species
Authors: Shima Yuto , Suzuki Takashi , Abe Hitoshi , Yajima Tatsuo , Mori Seiji , Shimazaki Yuichi
Published: May 2022

The reaction of CuII ion with dimethylaminophenolate ligands gave CuI–phenoxyl radical complexes under inert gas atmosphere in the absence of solvent coordination, and their electronic and geometric structures and reactivities were characterized.
Thermally stable zinc hydride catalyst for hydrosilylation of CO2 to silyl formate at atmospheric pressure
Authors: Baalbaki Hassan A. , Shu Julia , Nyamayaro Kudzanai , Jung Hyuk-Joon , Mehrkhodavandi Parisa
Published: May 2022

Neutral zinc complexes supported by H[PNNO], a diaminophenolate ligand bearing a pendant phosphine group, were synthesized and characterized.
Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi
Authors: Li Hang , Mirzayans Paul M. , Butler Mark S. , Lacey Alastair E. , Vuong Daniel , Chen Rachel , Kalaitzis John A. , Moggach Stephen A. , Lacey Ernest , Piggott Andrew M. , Chooi Yit-Heng
Published: May 2022

The discovery of a novel family of p-nitrobenzoylated piperazines from Aspergillus brevijanus revealed that the biosynthesis of p-nitrobenzoic acid in fungi is catalysed by a PABA synthase, an aminodeoxychorismate synthase and a cytochrome P450.
Redox noninnocence of the formazanate ligand applied to catalytic formation of α-ketoamides
Authors: Singh Vikramjeet , Kundu Abhishek , Singh Kirti , Adhikari Debashis
Published: May 2022

The redox noninnocence of the popular formazanate ligand backbone has been utilized for electron transfer and further synthesis of α-ketoamide from α-ketoacid and amine.
Neutral dicyanidoferrate(ii) metalloligands for the rational design of dysprosium(iii) single-molecule magnets
Authors: Liberka Michal , Zychowicz Mikolaj , Zychowicz Wiktor , Chorazy Szymon
Published: May 2022

Dicyanidobis(aromatic α,α′-diimine) Fe(ii) complexes efficiently constrain the equatorial plane of the Dy(iii) centre which opens a pathway for controlling the lanthanide magnetic anisotropy by placing organic N-oxides at axial positions.
Heterostructured Co-NTC@Co3S4 as an anode material for asymmetric pseudocapacitors
Authors: Liu Xinjie , Zhang Xinlong , Yin Qingyang , Liu Rongmei , Liu Ning , Hu Jiwen , Shen Fengcui , Zhu Xiandong
Published: May 2022

Herein, a composite structure of ZIF-67@Co-NTC was synthesized and it was partially vulcanized to form layer-like Co3S4 nanosheets to finally successfully synthesize a composite heterostructure of Co-NTC@Co3S4.
On the energetic stability of halogen bonds involving metals: implications in crystal engineering
Authors: Benito Ismael , Gomila Rosa M. , Frontera Antonio
Published: May 2022

This manuscript reports a CSD survey of X-ray structures exhibiting halogen bonds involving metals of group 10 as electron donors. The DFT study on several model systems discloses that the interactions are moderately strong.
Multi-channel photodissociation dynamics of 14N2 in its b′ 1Σ+u(ν = 20) state
Authors: Jiang Pan , Lu Liya , Liu Min , Gao Hong
Published: May 2022

Branching ratios into N(4S) + N(2D3/2,5/2), N(4S) + N(2P1/2,3/2) and N(2D3/2,5/2) + N(2D3/2,5/2) strongly depend on rotational levels, which reveals the multi-channel photodissociation dynamics of 14N2 in its b′ 1Σ+u(ν = 20) state.
Optical absorption and shape transition in neutral SnNclusters withN≤ 40: a photodissociation spectroscopy and electric beam deflection study
Authors: Lehr Andreas , Rivic Filip , Jäger Marc , Gleditzsch Martin , Schäfer Rolf
Published: May 2022

Quantum-chemically supported electric beam deflection and photodissociation spectroscopy reveal the shape evolution and optical absorption of small Sn clusters with focus on the rotational, vibrational, multiphoton and dissociation characteristics.
VCD spectroscopy reveals conformational changes of chiral crown ethers upon complexation of potassium and ammonium cations
Authors: Weirich Luisa , Tusha Gers , Engelage Elric , Schäfer Lars V. , Merten Christian
Published: May 2022

Analysis of the VCD spectra of the empty crown ether and its complex enable the characterization of conformational changes occurring upon guest encapsulation.
Degrader-antibody conjugates
Authors: Dragovich Peter S.
Published: May 2022

This review illustrates the design of antibody conjugates which employ chimeric protein degraders (i.e., PROTACs) as payloads and summarizes the examples of such entities that are currently known in the scientific and patent literature.
Emerging investigator series: meta-analyses on SARS-CoV-2 viral RNA levels in wastewater and their correlations to epidemiological indicators
Authors: Mantilla-Calderon David , Huang Kaiyu (Kevin) , Li Aojie , Chibwe Kaseba , Yu Xiaoqian , Ye Yinyin , Liu Lei , Ling Fangqiong
Published: May 2022

Recent applications of wastewater-based epidemiology (WBE) have demonstrated its ability to track the spread and dynamics of COVID-19 at the community level.
Concluding remarks: discussion on natural and artificial enzymes including synthetic models
Authors: Karlin Kenneth D. , Hota Pradip K. , Kim Bohee
Published: May 2022

This paper overviews the final remarks lecture delivered (by K. D. K.) at the end of this bioinorganic chemistryFaraday Discussion, held online for a worldwide audience from January 31 – February 3, 2022.
Effect of sea cucumber peptides on the immune response and gut microbiota composition in ovalbumin-induced allergic mice
Authors: Yun Liyuan , Li Wen , Wu Tao , Zhang Min
Published: May 2022

The prevalence of food allergies has increased in Asian countries.
H2O2-promoted C–C bond oxidative cleavage of β-O-4 lignin models to benzanilides using water as a solvent under metal-free conditions
Authors: Liu Xinwei , Wang Liguo , Zhai Lianjing , Wu Cailing , Xu Huanjun
Published: May 2022

Phenol and benzanilides were obtained through the oxidative amination of lignin models under transition metal-free conditions in H2Oviaa two-step reaction route.
A rapid construction strategy of NaYF4:Yb,Er@CDs nanocomposites for dual-mode anti-counterfeiting
Authors: Wei Haopeng , Zheng Yihao , Zhang Xingcai , Liang Ping , Xu Xiaokai , Hu Chaofan , Zhang Xuejie , Lei Bingfu , Liu Yingliang , Zhuang Jianle
Published: May 2022

A rapid construction strategy is reported to achieve the composite structure of NaYF4:Yb,Er and carbon dots (CDs) through electrostatic interactions.
Remote drug loading into liposomes via click reaction
Authors: Zheng Yaxin , Xie Lei , Tie Xiaoru , Cao Lei , Li Qingyuan , Quan Yue , Tang Lingfeng , Li Yang
Published: May 2022

We developed a click reaction-mediated active loading strategy, in which the drug loading was achieved by the generation of hydrophilic products in the liposome's lumen from the click reaction of glutathione with drug-maleimide conjugates.
Incorporating plasmonic featurization with machine learning to achieve accurate and bidirectional prediction of nanoparticle size and size distribution
Authors: Tan Emily Xi , Chen Yichao , Lee Yih Hong , Leong Yong Xiang , Leong Shi Xuan , Stanley Chelsea Violita , Pun Chi Seng , Ling Xing Yi
Published: May 2022

Schematic of our bidirectional, ML-empowered approach incorporating plasmonic featurization for rapid (<30 s) and accurate determination of the size and size distribution of gold nanosphere (Au NSs) ensembles in real samples.
Structure–property relationships of diketopyrrolopyrrole- and thienoacene-based A–D–A type hole transport materials for efficient perovskite solar cells
Authors: Kini Gururaj P. , Parashar Mritunjaya , Jahandar Muhammad , Lee Jaewon , Chung Sein , Cho Kilwon , Shukla Vivek Kumar , Singh Ranbir
Published: May 2022

Two DPP-based hole-transporting materials with different aromatic π-bridges have been synthesized and tested for perovskite solar cells. Improved power conversion efficiency and stability were achieved by employing DPP-TT.
In situ fabrication of cobalt sulfide-decorated N,S co-doped mesoporous carbon and its application as an electrocatalyst for efficient oxygen reduction reaction
Authors: Parthiban V. , Sruthibhai P. V. , Menon Rahul S. , Panda Subhendu K. , Sahu A. K.
Published: May 2022

Oxygen reduction reaction (ORR) activity of N,S co-doped mesoporous carbon.
A novel water-soluble naphthalimide-based turn-on fluorescent probe for mercury ion detection in living cells and zebrafish
Authors: Su Meijun , Liu Caiyun , Liang Yuying , Zhang Yan , Rong Xiaodi , Wang Xin , Li Xiwei , Wang Kun , Zhu Hanchuang , Yu Miaohui , Sheng Wenlong , Zhu Baocun
Published: May 2022

A highly selective and sensitive water-soluble naphthalimide-based turn-on fluorescent probe was synthesized to detect Hg2+ in living cells and zebrafish.
Unravelling the catalytic potential of a magnetic CoFe2O4/Cu–ABDC MOF composite in the sustainable synthesis of 2H-indazole motifs
Authors: Yadav Sneha , Dixit Ranjana , Sharma Shivani , Dutta Sriparna , Arora Bhavya , Rana Pooja , Kaushik Bhawna , Solanki Kanika , Sharma Rakesh K.
Published: May 2022

A magnetic CoFe2O4/Cu–ABDC hybrid composite was fabricated for the synthesis of biologically active and pharmacologically significant 2H-indazole scaffolds.
Tailoring the surface chemistry of hard carbon towards high-efficiency sodium ion storage
Authors: Shen Chao , Wang Chuan , Jin Ting , Zhang Xianggong , Jiao Lifang , Xie Keyu
Published: May 2022

The HC surface modified by low-temperature oxygen plasma plasma realized increased ordered structure, reduced defects and increased oxygen functional groups, thus leading to high-efficiency sodium ion storage.
Tuning the photodynamics of sub-nanometer neutral chromium oxide clusters through sequential oxidation
Authors: Garcia Jacob M. , Sayres Scott G.
Published: May 2022

Excited state dynamics of chromium oxide clusters change linearly upon sequential oxidation, matching the O-2p to Cr-3d photoexcitation charge transfer character and shifts between semiconducting and metallic behavior at the molecular level.
Temperature-dependent CO2 sorption and thermal-reduction without reactant gases on BaTiO3 nanocatalysts at low temperatures in the range of 300–1000 K
Authors: Watanabe Takumi , Ohba Tomonori
Published: May 2022

Low temperature CO2 reduction and mechanism on BaTiO3 nanocatalysts from 500 K, CO2 physical adsorption at 300–500 K, CO2 chemisorption above 450 K, CO2 reduction at 500–850 K, and CO2 and CO release above 800 K.
Honeycomb-like 3D carbon skeletons with embedded phosphorus-rich phosphide nanoparticles as advanced anodes for lithium-ion batteries
Authors: Mao Xiaoge , Wu Kuan , Li Shang-Qi , Du Fei-Hu , Xu Gang , Wu Minghong , Liu Hua-Kun , Dou Shi-Xue , Wu Chao
Published: May 2022

A 3D honeycomb-like carbon skeleton with embedded FeP2 nanoparticles has been designed and synthesized, showing an excellent electrochemical performance reflected by high reversibility and long-term cycling stability.
Conjugating AIE-featured AuAg nanoclusters with highly luminescent carbon dots for improved visible-light-driven antibacterial activity
Authors: Liu Naiwei , Wang Yichun , Wang Ziping , He Qiuxia , Liu Yong , Dou Xinyue , Yin Zhengmao , Li Yang , Zhu Haiguang , Yuan Xun
Published: May 2022

Conjugating AIE-featured AuAg nanoclusters with luminescent carbon dots achieves broad-spectrum yet high-efficiency photodynamic antibacterial activities.
Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening
Authors: Yang Shilun , Li Simeng , Chang Junlei
Published: May 2022

The integrated virtual screening pipeline was constructed to identify potential inhibitors of A-FABP in the latest FDA-approved drug library, aiming to explore the existing drugs with proven safety profiles.
Benzo[de]isoquinoline-1,3-dione condensed asymmetric azaacenes as strong acceptors
Authors: Zhou Pengxin , Deng Lanlan , Han Zengtao , Zhao Xiaolong , Zhang Zhe , Huo Shuhui
Published: May 2022

Three benzo[de]isoquinoline-1,3-dione (BQD) condensed asymmetric azaacenes, BQD-TZ, BQD-AP andBQD-PA, with different end groups, have been successfully synthesized and their structures were confirmed by single-crystal X-ray diffraction.
Molybdenum disulfide composite materials with encapsulated copper nanoparticles as hydrogen evolution catalysts
Authors: Wang Chuangye , Zhao Wenjing , Jiang Huixin , Cui Mengyu , Jin Yu , Sun Ruixue , Lin Xufeng , Zhang Longli
Published: May 2022

Encapsulation of copper nanoparticles by the electrochemical catalyst MoS2 effectively improved its HER performance.
Prospective application of phosphorylated carbon nanofibers with a high adsorption capacity for the sequestration of uranium from ground water
Authors: Dhanya V. , Arunraj Balasubramanian , Rajesh N.
Published: May 2022

Adsorption of uranium at pH 6.0 using phosphorylated carbon nanofibers.
Retraction: Structural characterization of ginseng oligopeptides and anti-aging potency evaluation in Caenorhabditis elegans
Authors: Fisher Laura
Published: May 2022

Retraction of ‘Structural characterization of ginseng oligopeptides and anti-aging potency evaluation in Caenorhabditis elegans’ by Qiang Luo et al., RSC Adv., 2020, 10, 39485–39494, https://doi.org/10.1039/D0RA06093C.
Vessel effects in organic chemical reactions; a century-old, overlooked phenomenon
Authors: Nielsen Michael Martin , Pedersen Christian Marcus
Published: May 2022

One of the most intriguing aspects of synthetic chemistry is the interplay of numerous dependent and independent variables en route to achieve a successful, high-yielding chemical transformation.
Why heterogeneous single-atom catalysts preferentially produce CO in the electrochemical CO2 reduction reaction
Authors: Wang Yu , Liu Tianyang , Li Yafei
Published: May 2022

This report discloses a nontrivial role of the CO2 adsorption mode in governing the CO/formate selectivity of single-atom catalysts towards two-electron CO2 reduction.
Investigating the entropic nature of membrane-mediated interactions driving the aggregation of peripheral proteins
Authors: Sadeghi Mohsen
Published: May 2022

Peripheral membrane-associated proteins can aggregate on the surface of biomembranes as a result of quantifiable membrane-mediated interactions. A continuous measure of aggregation facilitates investigating the nature of these interactions.
Vortex evolution patterns for flow of dilute polymer solutions in confined microfluidic cavities
Authors: Xue Chun-Dong , Zheng Zhou-Yi , Zheng Guo-Shuang , Zhao De-Wei , Qin Kai-Rong
Published: May 2022

Three typical patterns of vortex evolution are identified in the cavity flow of dilute polymer solutions over a wide range of flow conditions.
Correction: The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions
Authors: Wang Dong , Treado John D. , Boromand Arman , Norwick Blake , Murrell Michael P. , Shattuck Mark D. , O'Hern Corey S.
Published: May 2022

Correction for ‘The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions’ by Dong Wang et al., Soft Matter, 2021, 17, 9901–9915, DOI: 10.1039/D1SM01228B.
The impact of carbonation on hydroxide diffusion in nano-confined anion exchange membranes
Authors: Zelovich Tamar , Simari Cataldo , Nicotera Isabella , Dekel Dario R. , Tuckerman Mark E.
Published: May 2022

Exposing anion exchange membrane (AEM) fuel cells to ambient air is known to decrease fuel cell efficiency significantly due to the presence of CO2.
A dopant-free donor–acceptor type semi-crystalline polymeric hole transporting material for superdurable perovskite solar cells
Authors: Kim Dong Won , Choi Min-Woo , Yoon Won Sik , Hong Seung Hwa , Park Sungjin , Kwon Ji Eon , Park Soo Young
Published: May 2022

Dopant-free semi-crystalline PNTDT-2F2T shows superior electrical and thermal properties leading to an efficiency of 22.19% and superior long-term stability.
Dual-metal Ni and Fe phthalocyanine/boron-doped g-C3N4Z-scheme 2D-heterojunctions for visible-light selective aerobic alcohol oxidation
Authors: Liu Haiyue , Chu Xiaoyu , Bai Linlu , Yang Zhaodi , Jiao Yuming , Li Wensen , Zhang Yanhong , Jing Liqiang
Published: May 2022

The wide-spectrum NiPc–FePc/BCN Z-scheme heterojunctions have been successfully constructed with exceptional photoactivity depending on the cascade Z-scheme electron transfer from BCN to NiPc–FePc, and the synergy of NiPc and FePc promote O2 reduction.
Fabrication of human serum albumin–imprinted photothermal nanoparticles for enhanced immunotherapy
Authors: Ma Jizhuang , Zhang Yao , Sun Hongyi , Ding Pingtian , Chen Dawei
Published: May 2022

The molecularly imprinted polymers coated on the Fe3O4 nanoparticles not only contribute to forming an albumin-rich corona on the surface of Fe3O4 nanoparticles, but also enhance the photothermal conversion of Fe3O4 nanoparticles.
A robust immune-related lncRNA signature for the prognosis of human colorectal cancer
Authors: Zhu Gongmin , Pei Lijiao , Yang Fan , Zhang Chenliang
Published: May 2022

Background: Colorectal cancer (CRC) is one of the most prevalent malignant cancers worldwide. Immune-related long non-coding RNAs (IRlncRNAs) are proved to be essential in the development and progression of carcinoma. The purpose of the present study was to develop and validate a prognostic IRlncRNA signature for CRC patients.

Methods: Gene expression profiles of CRC samples were downloaded from The Cancer Genome Atlas (TCGA) database. Immune-related genes were obtained from the ImmPort database and were used to identify IRlncRNA by correlation analysis. Through LASSO Cox regression analyses, a prognostic signature was constructed. Functional enrichment analysis was performed by gene set enrichment analysis (GSEA). TIMER2.0 web server and tumor immune dysfunction and exclusion (TIDE) algorithm were employed to analyze the association between our model and tumor-infiltrating immune cells and immunotherapy response. The expression levels of IRlncRNAs in cell lines were detected by quantitative real-time PCR (qPCR).

Results: A 9-IRlncRNA signature was developed by a LASSO Cox proportional regression model. Based on the signature, CRC patients were divided into high- and low-risk groups with different prognoses. GSEA results indicated that patients in high-risk group were associated with cancer-related pathways. In addition, patients in low-risk group were found to have more infiltration of anti-tumor immune cells and might show a favorable response to immunotherapy. Finally, the result of qPCR revealed that most IRlncRNAs were differently expressed between normal and tumor cell lines.

Conclusion: The constructed 9-IRlncRNA signature has potential to predict the prognosis of CRC patients and may be helpful to guide personalized immunotherapy.
Analysis of community question‐answering issues via machine learning and deep learning: State‐of‐the‐art review
Authors: Roy Pradeep Kumar , Saumya Sunil , Singh Jyoti Prakash , Banerjee Snehasish , Gutub Adnan
Published: May 2022

Over the last couple of decades, community question‐answering sites (CQAs) have been a topic of much academic interest. Scholars have often leveraged traditional machine learning (ML) and deep learning (DL) to explore the ever‐growing volume of content that CQAs engender. To clarify the current state of the CQA literature that has used ML and DL, this paper reports a systematic literature review. The goal is to summarise and synthesise the major themes of CQA research related to (i) questions, (ii) answers and (iii) users. The final review included 133 articles. Dominant research themes include question quality, answer quality, and expert identification. In terms of dataset, some of the most widely studied platforms include Yahoo! Answers, Stack Exchange and Stack Overflow. The scope of most articles was confined to just one platform with few cross‐platform investigations. Articles with ML outnumber those with DL. Nonetheless, the use of DL in CQA research is on an upward trajectory. A number of research directions are proposed.