bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells
Authors: KOLAÇ Umut Kerem , Yalcin Gizem Donmez , Yalcin Abdullah
Published: June 2022

Gestational diabetes mellitus (GDM) is a metabolic complication that affects millions of pregnant women in the world. Placental tissue function is endangered by hyperglycemia during GDM, which is correlated to increased incidences of pregnancy complications. Recently we showed that due to a significant decrease in mitochondrial fusion, mitochondrial dynamics equilibrium is altered in placental tissues from GDM patients. It is not known whether the decrease in mitochondrial fusion causes a decrease in mitochondrial function in placental cells. Here we show that chemical inhibition of mitochondrial fission in cultured placental trophoblast cells leads to an increase in mitochondrial fusion and improves the physiological state of these cells and hence, their capacity to cope in a hyperglycemic environment. Specifically, mitochondrial fission inhibition led to a reduction in reactive oxygen species (ROS) generation, mitochondrial unfolded protein marker expressions, and mitochondrial depolarization. It supported the increase in mitochondrial antioxidant enzyme expressions as well. Mitochondrial fission inhibition also increases the placental cell insulin sensitivity during hyperglycemia. Our results suggest that mitochondrial fusion/fission equilibrium is critical for placental cell function and signify the therapeutic potential of small molecule inhibitors of fission during GDM.
Efficacy and safety of Anlotinib plus PD-1 blockade for the treatment of advanced non-small cell lung cancer: A Retrospective study
Authors: Pan Xiaoting , Dai Anwei
Published: June 2022

Purpose: Both anlotinib and programmed cell death protein 1(PD-1) have been demonstrated anti-tumor efficacy in non-small cell lung cancer (NSCLC) in clinical. However, the number of prospective research of this combination therapy is limited in the literature. In this retrospective study, we aim to evaluate the efficacy and safety of anlotinib plus PD-1 blockade for the treatment of advanced NSCLC patients. Methods: 40 advanced NSCLC patients who received combination treatment at traditional Chinese medicine hospital of Kunshan were selected between January 1, 2020 and December 31, 2021 and 31 eligible patients were screened for further study. Progression free survival (PFS) and overall survival (OS) were the primary end points. The safety of the combination treatment was assessed by the incidence of adverse events. Results: The combined therapeutic regimen of anlotinib and PD-1 blockade in 31 advanced NSCLC patients gained a median PFS of 6.4 months (95% CI 5.4-7.4 months) and the median overall survival(mOS) was 15.4 months (95% CI 13.4-17.4 months). Of all the eligible patients, 4 patients achieved partial respone(PR) and none of these patients achieved complete response(CR). The overall response rate(ORR) and the disease control rate(DCR) were 12.9% and 54.8% respectively. The common adverse events were fatigue, loss of appetite, nausea, hypertension and hand-foot syndrome during the treatment.Conclusion: The combination of anlotinib and PD-1 blockade has promising efficacy for the advanced NSCLC patients and the toxicity is tolerable.
Disentangling Interest and Conformity for Eliminating Popularity Bias in Session-Based Recommendation
Authors: Liu Qidong , Tian Feng , Zheng Qinghua
Published: June 2022

Session-Based Recommendation (SBR) is to predict next item, given an anonymous interaction sequence. Recently, many advanced SBR models show great recommending performance, but few studies note that they suffer from popularity bias seriously: the model tends to recommend popular items and fails to recommend long-tail items. The only few debias works relieve popularity bias indeed. However, they ignore individual's conformity towards popular items and thus decrease recommending performance on popular items. Besides, conformity is always entangled with individual's real interest, which hinders extracting one's comprehensive preference.
To tackle the problem, we propose a SBR framework with Disentangling InteRest And Conformity (DIRAC) for eliminating popularity bias in SBR. In this framework, two group of item encoders and session modeling modules are devised to extract interest and conformity respectively, and a fusion module is designed to combine these two types of preference. Also, a discrepancy loss is utilized to disentangle representation of interest and conformity. Besides, our devised framework can integrate with several SBR models seamlessly. We conduct extensive experiments on two real-world datasets with three advanced SBR models. The results show that our framework outperforms other state-of-art debias methods consistently.
Electrical Impedance Tomography Imaging of Oxygen Therapy with High Flow Nasal Cannula in Patients with COVID-19 Acute Respiratory Distress Syndrome
Authors: Öner Özlem , Ergan Begüm , Duğral Esra , Kızıl Ayşe Sezin , Gürkok Mehmet Çağatay , Gökmen Ali Necati
Published: June 2022

PurposeThe aim of this study is to visualize the effect of a high flow nasal cannula (HFNC) in patients with the diagnosis of COVID-19 acute respiratory distress syndrome (C-ARDS) followed up in intensive care unit (ICU) with the use of electrical impedance tomography (EIT). Methods Two different flow rates oxygen therapy in supine and prone positions were applied to the patients with HFNC. Patients’ EIT-based parameters (global inhomogeneity index (GI index), Center of Ventilation (CoV), Regional Ventilation Delay index (RVD index), Region of Interest Ratio (ROI ratio)), respiratory and hemodynamic parameters were recorded from the database.ResultsTwenty patients were included in this retrospective observational study.When the flow rate gradually increased from baseline to 50 L/min and prone position; a significant and consistent descreasing trend of GI index: 0,55±0,02 (p < 0.0001), CoV: 42,98±0,93 (p <0.0001), RVD index: 3,38±1,13 (p = 0.006), ROI ratio:1,39±0,16 (p <0.0001), respiartory rate: 21,3±3,57 (p < 0.0001), mean arterial pressure: 81,5±10,95 (p=0.004) and inreasing PaO2/FiO2. ratio (partial arterial oxygen pressure/fraction of inspired oxygen): 203,1±33,44 ((p < 0.0001) were observed. ConclusionIt was found that lung homogeneity in following C-ARDS patients in the prone position increases according to the evaluation of EIT parameters, respiratory and hemodynamic parameters.
Dissecting transcriptional heterogeneity in multiple primary lung cancer by single cell RNA sequencing
Authors: Guo Wei , Xia Hao , Huai Qilin , Xue Xuemin , Guo Lei , Tan Fengwei , Zhao Jun , Xue Qi , Gao Shugeng , He Jie , Zhou Bolun
Published: June 2022

The progression of multiple primary lung cancer (MPLC) involves complex changes in cell composition and metabolic function. Here, we performed scRNA sequencing of 167,397 cells from six patients with MPLC, combined with bulk whole-exome sequencing. We revealed that both naïve and memory T cells participate in the differentiation of CD8+ T cells. The terminal states of CD8+ T cells are exhausted T cells, which respond to stimuli and positively regulate cell death, and cytotoxic T cells, which are mainly implicated in the regulation of cytokine production. Multiple functional Tregs and naïve T cells contribute to the origin of CD4+ T cells. B cells, with two main functions, also play important roles in the immune response. We also uncovered the cellular metabolic activities that occur during tumor invasion. Positive regulation of blood vessel diameter has been observed in endothelial cells, while angiogenesis has not been found in early glandular neoplasia of the lung. The development of epithelial cells involves two functional states. In one state, cells respond to stress from the immune system, and in the other, some will undergo programmed cell death or enter the cell cycle due to the selective pressure that arises over the course of tumor development in synchronous MPLC. Our study showed the complete landscape of different dynamic cellular changes, which might reveal the key cellular mechanisms of MPLC and therefore provide new clues for the pathogenesis of tumors.
Heavy Metals in Alcoholic Beverages Consumed in Awka, South-East Nigeria: Carcinogenic and Non-carcinogenic Health Risk Assessments
Authors: OKAFOR VINCENT , Omokpariola Daniel Omeodisemi , Okabekwa Chiamaka Valerine , Umezinwa Emmanuel Chukwuanu
Published: June 2022

Consumption of alcoholic beverages has been a long-standing tradition that dates back to the use of fruit-based cereals and vegetable substrates. Selected international, national, and local-based alcoholic beverages (herbal gin, imported red wine, Heineken, imported dry gin, local dry gin, palm wine, Guinness stout, and whisky) were purchased from popular drinking joints in Awka metropolis, Anambra state, Nigeria, where questionnaires were administered to respondents in order to get the actual consumption rate. Using Atomic Absorption Spectrophotometer (AAS), heavy metals (Cd, Cr, Cu, Fe, Pb, Mn, Ni, and Zn) were analyzed. Background references from the World Health Organization (WHO) and the International Organization of Grapes and Wines (IOGW) were used to assess contamination and pollution potential. After determining the average daily intake (ADI) for non-carcinogenesis and carcinogenesis, the hazard index and overall cancer risk were calculated using reference dosage and cancer slope factor. Heavy metal analysis showed that Cu and Zn were found to be the most prevalent in all alcoholic beverages. There are no known health risks as a result of the contamination and pollution potential. Heineken and palm wine were both above 1 on the hazard index, indicating that there were potential health issues. However, cancer risk analysis revealed that all beverages were above the US EPA's recommended range of 1.00E06–1.00E04, implying that cancer-related illness is likely in a population of 1 in 1000 to 10,000 people. As a result, alcoholic beverage manufacturers should strive for continuous improvement in order to avoid public health issues.
Overweight Ecuadorian undergraduate medical students show higher levels of daytime sleepiness and poor sleep quality. Quito, Ecuador.
Authors: Fors Martha , González Paloma , Ascuntar Nathalia , Viada Carmen , Falcón Kirsten , Fernandez-Moreira Esteban
Published: June 2022

Introduction: Some studies have demonstrated the association between overweight or obesity and sleep, specifically with poor sleep quality. The objective of this paper is to examine the association between sleep quality, excessive somnolence with body mass index (BMI) in medical students.Method: This cross-sectional study included 219 subjects. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and somnolence with Epworth Sleepiness Scale (ESS).Results: The overall mean BMI was 23.08 kg/m2. We found that 17.4% of the students were overweight or obese. The mean value for ESS was 10.21±3.98 points, showing that 42.0% of all the students has diurnal sleepiness. The mean score for PSQI was of 8.04±2.78 and we observed that 86.3% of the students had poor quality of sleep. PSQI index was higher in overweight and obese students. The mean self-reported nightly sleep duration was 6.3 hours and 37.5% of the students has a sleep efficiency under 85%. Poor sleep quality and BMI were significantly and positive correlated. Conclusions: Poor sleep quality is a common condition in medical students among overweight and obese subjects.
Lumbar multifidus muscle morphology is associated with low back-related pain duration, disability, and leg pain: a cross-sectional study in secondary care.
Authors: Cooley Jeffrey , Kjaer Per , Jensen Tue , Jacques Angela , Theroux Jean , Hebert Jeffrey
Published: June 2022

Background: Systematic reviews and studies exploring associations between morphologic change of paraspinal muscles and low back pain or related outcomes such as disability, radiculopathy, and physical workload, have reported conflicting results. This study explores the associations between lumbar multifidus muscle quality and clinical outcomes related to low back pain.Methods: Cross-sectional study of spinal clinic outpatients presenting with a primary complaint of low back and/or leg symptoms. Univariable and multivariable regression models were used to investigate associations between MRI-based multifidus muscle cross-sectional area at L4 and L5 and clinical outcomes for low back and leg pain, disability, restricted motion, and strenuous nature of work. Results were reported with β-coefficients, odds ratios (OR), or incidence rate ratios (IRR) and their corresponding 95% confidence intervals, based on a 10% difference in muscle quality for each clinical variable. Multivariable analyses were adjusted for age, sex, and BMI.Results: 875 patients [487 females; mean (SD) age: 43.6 (10.2) years] were included. In the multivariable analyses, muscle quality was significantly associated with disability (0-23 scale) [β: -0.74, 95% CI: -1.14, -0.34], leg pain intensity (0-10 scale) [β: -0.25, 95% CI: -0.46, -0.03], and current pain duration of more than 12 months [OR: 1.27, 95% CI: 1.03, 1.55]. No associations were found for low back pain intensity, morning stiffness, painful active range of motion, or work nature.Conclusions: Patients with higher lumbar multifidus muscle quality reported lower levels of low back pain-related disability and leg pain intensity, indicating that muscle quality may play a role in the etiology of lumbar spine disorders. However, the clinical importance of these associations is uncertain. Future longitudinal studies are needed to understand the effect of lumbar multifidus muscle quality on lumbar-related pain and disability.
Analysis of related factors of primary and recurrent fractures in postmenopausal osteoporotic patients: A Retrospective Study
Authors: Zhu Xiaonan , Chen Lin , Zeng Yuexi , Fu Qiang , Liu Yanbin , Peng Yongde , Wang Yufan , You Li , pan ling
Published: June 2022

Objective: To analyze the factors associated with primary and recurrent fractures in Chinese postmenopausal women with osteoporosis.Methods: A retrospective analysis of 2478 postmenopausal osteoporosis (PMOP) patients who attended the Shanghai General Hospital from January 2007 to December 2016, including 1239 patients with no fractures and 1239 patients with a history of fracture (1008 in the primary fracture group and 231 in the re-fracture group). All patients' basic clinical data, serum biochemical and bone metabolic markers, bone mineral density (BMD), and other indicators were recorded uniformly. SPSS.26 was used for statistical analysis.Results: 1. Compared with the non-fractured group, the fractured group had higher age, lower height, and lower bone mineral density (all P<0.01). The re-fractured group had lower bone mineral density than the primary fracture group at each key site (all P<0.01). 2. Analysis of the combined disease subgroups showed that: 1) the serum BGP level was lower in the subgroup with diabetes in the primary fracture group than in the subgroup without diabetes (P<0.05). 2) The recurrent fracture group with diabetes had lower serum CTX and BGP levels than the subgroup without diabetes (P<0.05); the subgroup with cardio-cerebrovascular diseases had lower bone mineral density than the subgroup without cardio-cerebrovascular diseases (P<0.05); 3) In the subgroup with diabetes, the subgroup with recurrent fracture had lower serum CTX levels than the subgroup with primary fracture (P<0.05); in the subgroup with cardio-cerebrovascular diseases, the subgroup with recurrent fracture had lower bone mineral density than the subgroup with primary fracture. 3. Multiple logistic regression analysis showed that advanced age, overweight, low lumbar spine and total hip BMD, and combined chronic liver and kidney diseases were independent risk factors for primary fractures; advanced age, overweight, low lumbar spine and total hip BMD were independent risk factors for recurrent fractures. ﻿Conclusion: Postmenopausal osteoporotic patients with advanced age, overweight, low bone mineral density, and comorbid chronic liver and kidney diseases are at greater risk of fractures and require early intervention to reduce fractures occurrence. Moreover, those who are elderly, overweight, and have low bone density should also be aware of the risk of re-fractures.
A new causative heat supply for exertional heat stroke on runners in cold air
Authors: Tagami Kazumi , Yuan Shenghua , Ota-Kotner Adriana
Published: June 2022

Objective
The dysregulation in heat balance, the main cause of exertional heat stroke, occurs not only in midsummer but also in the cold season. Possible causes of this are a reduction in convection and evaporation due to tailwinds and an acceleration of radiant heat inflow. Although the amount of radiant heat that reaches the surface can be estimated, the actual amount of heat flows into the body cannot be specified yet. This paper made an experimental attempt for this.
METHODS
A device is made up of a temperature controllable heat sink and heat flow detector, which keeps the surface temperature constant and has a heat exchange coefficient comparable to that of the human body surface. The output of this device (total heat exchange) was divided into radiant heat exchange and other heat exchange using a standard radiant heat calibrator, Leslie Cube.
RESULTS
A phenomenon, in which a wet surface while the surface temperature was low absorbed larger heat than that of the dry surface, was found. And authors named this "hidden heat inflow". As a result of multiple regression analyses, both radiant heat exchange and other heat exchanges are closely related to the surface temperature, and the maximum difference in total heat exchange during the experiment reached 200 kcal/m2/h. It has been suggested that this phenomenon may also occur on the surface of human skin.
DISCUSSION
One of the causes of this “hidden heat inflow” is considered to be the decrease in evaporative cooling due to the decrease in surface temperature. However, this alone cannot explain all of the phenomena, so water vapor aggregation may also be involved. A "hidden heat inflow" as a sufficient heat source for exertional heat stroke or collapse during a marathon race on a cold day was evidenced experimentally.
Contribution value: A indicator for measuring the contribution of ncRNAs to transcriptome
Authors: Gu Xinyi , Wang Shen , Jin Bo , Qi Zhidan , Deng Jin , Huang Chen , Yin Xiaofeng
Published: June 2022

The log2 fold change (FC) and P value are often the main basis for screening ncRNA after high-throughput sequencing. Considering the strong regulatory function of ncRNAs on genes, we tried to propose a new indicator Contribution value (C value) to quantify the regulatory effect of ncRNAs on the transcriptome, in order to better screen ncRNAs with great potential. In this study, we analyzed multiple data sets from mice and humans. All differentially expressed genes (DEGs) were used as parent sets for GO and KEGG enrichment analysis. C values were calculated based on the target genes of ncRNAs and the pathways they participate in. The ncRNAs screened by C value regulated more DEGs, and these DEGs were more concentrated in the core region of protein-protein interaction (PPI) network. In addition, disease-critical ncRNAs are easier to be screened by C value. Collectively, we found that the C value provides a measure of another dimension compared with the log2FC and P value. These hidden interactions between ncRNAs and their target genes may provide more comprehensive analysis.
Characterizing mobility patterns of forest goersin southern Lao PDR using GPS loggers.
Authors: Rerolle Francois , Dantzer Emily , Phimmakong Toula , Lover Andrew , Hongvanthong Bouasy , Phetsouvanh Rattanaxay , Marshall John , Sturrock Hugh , Bennett Adam
Published: June 2022

Background
In the Greater Mekong Subregion (GMS), forest-going populations are considered high-risk populations for malaria and are increasingly targeted by national control programs’ elimination efforts. A better understanding of forest-going populations’ mobility patterns and risk associated with specific types of forest-going trips is necessary for countries in the GMS to achieve their objective of eliminating malaria by 2030.
Methods
Between March and November 2018, as part of a focal test and treat intervention (FTAT), we recruited 2,904 forest-goers in southern Lao PDR. A subset of forest-goers carried an “i-Got-U” GPS logger for roughly two months, configured to collect GPS coordinates every 15 to 30 minutes. The utilization distribution (UD) surface around each GPS trajectory was used to extract trips to the forest and forest-fringes. Trips with shared mobility characteristics in terms of duration, timing and forest penetration were identified by a hierarchical clustering algorithm. Then, clusters of trips with increased exposure to dominant malaria vectors in the region were further classified as high-risk. Finally, we used gradient boosting trees to assess which of the forest-goers’ socio-demographic and behavioral characteristics best predicted their likelihood to engage in such high-risk trips.
Results
A total of 122 forest-goers accepted carrying a GPS logger resulting in the collection of 803 trips to the forest or forest-fringes. Six clusters of trips emerged, helping to classify 385 (48%) trips with increased exposure to malaria vectors based on high forest penetration and whether the trip happened overnight. Age, outdoor sleeping structures and number of children were the best predictors of forest-goers’ probability of engaging in high-risk trips. The probability of engaging in high-risk trips was high (~ 33%) in all strata of the forest-going population.
Conclusion
This study characterized the heterogeneity within the mobility patterns of forest-goers and attempted to further segment their role in malaria transmission in southern Lao People’s Democratic Republic (PDR). National control programs across the region can leverage these results to tailor their interventions and messaging to high-risk populations and accelerate malaria elimination.
Longitudinale strukturelle MRT zur Untersuchung der Hirnatrophie von Patienten mit Morbus Parkinson und kognitiver Beeinträchtigung
Authors:   , Seitz Florian David
Published: June 2022

Hintergrund: Die leichte kognitive Störung (engl. Mild cognitive impariment, MCI) ist ein wichtiges nicht-motorisches Symptom der Parkinson-Krankheit (PD) und ein Hochrisiko-Zustand für die Entwicklung einer Parkinson-Demenz (PDD). Die Etablierung von Biomarkern für ein MCI bei PD-Patienten (PD-MCI) könnte sowohl die Diagnosestellung als auch das Therapiemonitoring verbessern. Ziel: Es ist bekannt, dass PDD-Patienten im Vergleich zu PD-Patienten ohne kognitive Beeinträchtigung (engl. PD normal cognition, PD-NC) in der strukturellen Magnetresonanztomographie (MRT) eine ausgeprägte kortikale und subkortikale Hirnatrophie aufweisen. Die Datenlage für Patienten mit PD-MCI ist deutlich heterogener, zudem wurden bisher vor allem de novo-Patienten untersucht. Mittels longitudinaler struktureller MRT soll in dieser multizentrischen Studie herausgefunden werden, ob der beginnende kognitive Abbau von Parkinson-Patienten im mittleren Krankheitsstadium ebenfalls mit Volumenänderungen kritischer Hirnstrukturen assoziiert ist. Die Hypothese ist, dass Patienten mit PD-MCI sich durch eine reduzierte mittlere kortikale Dicke sowie durch die Atrophie des Hippocampus und ggf. weiterer subkortikaler Strukturen von PD-NC-Patienten und von gesunden Kontrollen (engl. healthy controls, HC) unterscheiden. Methode: 59 Patienten mit PD-NC, 49 Patienten mit PD-MCI sowie 59 HC erhielten zu Beginn der Studie und nach 12 Monaten eine ausführliche neuropsychologische Testung und eine strukturelle MRT-Untersuchung. Die MRT-Daten wurden mit der Freesurfer-Software automatisiert segmentiert, die mittlere kortikale Dicke sowie subkortikale Volumina und deren Atrophieraten berechnet und Gruppenvergleiche angestellt. Ergebnisse: Verglichen mit HC zeigte sich bei Patienten mit PD-MCI eine signifikant geringere mittlere kortikale Dicke sowie ein reduziertes Volumen des linken Thalamus, des Hippocampus und des Nucleus caudatus. Zwischen Patienten mit PD-MCI und PD-NC fanden sich dagegen keine signifikanten Volumenunterschiede. Für kognitiv beeinträchtigte PD-Patienten zeigte sich über 12 Monate eine signifikant höhere Atrophierate des rechten Thalamus, sowohl verglichen mit kognitiv unauffälligen PD-Patienten als auch verglichen mit HC. Für alle anderen untersuchten Strukturen unterschieden sich die Atrophieraten zwischen allen drei Gruppen nicht signifikant. Schlussfolgerung: PD-MCI ist im mittleren Stadium der Parkinson-Krankheit mit einer reduzierten kortikalen Dicke sowie einer die Altersnorm überschreitenden Atrophie des Thalamus, des Hippocampus und des Striatums assoziiert. Aufgrund der geringen Volumenunterschiede zwischen den einzelnen Gruppen und der hohen interindividuellen Variabilität ist die Sensitivität der Methode allerdings nicht ausreichend, um MR-basiert zwischen Parkinson-Patienten mit MCI und solchen mit normaler Kognition zu unterscheiden.
Translanguaging in an English First Additional Language context in the further education and training phase
Authors: Zano Kufakunesu
Published: June 2022

English is used as a medium of teaching and learning in most South African public schools although most of these learners are English First Additional Language (EFAL) speakers. To counter this anxiety, translanguaging as a multilingual intervention becomes handy. Translanguaging is about engaging in multilingual discourse practices; it is an approach to bilingualism that is centred not on languages, as has been often the case but on the practices of bilinguals that are readily observable. This study aimed at exploring how grade 11 EFAL learners feel/behave when the teacher orders them to abandon their home languages the moment they enter the classroom and how to promote one’s home language in the classroom.This qualitative study involved 12 grade 11 EFAL learners, equally divided into two interview focus groups. These EFAL learners were purposively selected from one education district in South Africa. The findings indicate that learning involves building on what the learner knows, so that the learner brings it to the current situation, restructures it and creates new knowledge. Also, more knowledge is needed about how to prepare teachers to best serve multilingual learner populations, including how to incorporate new understandings of translanguaging into instruction and assessment practices.
PEMBERDAYAAN EKONOMI UMAT: “PEMANFAATAN LINGKUNGAN DISEKITAR RUMAH UNTUK BUDIDAYA BAYAM BRAZIL DI ERA PANDEMI”
Authors: Budiarso Tri Yahya , Amarantini Charis , Prihatmo Guruh
Published: June 2022

Brazilian spinach is a type of spinach that has not been widely consumed and cultivated by the Indonesian people even though it has excellent health benefits and is easy to cultivate. This Brazilian spinach cultivation training aims to empower the community during the pandemic by utilizing the land around the house or planting it in pots. The training participants were members of the GKI and GKJ churches from DIY and Central Java as well as some from Eastern Indonesia. Training participants are limited to 20 people with strict health protocols. The training materials are in the form of providing theory and direct practice in preparing seeds, media and planting as well as education about the benefits of brazil spinach for health. The results of this training were in the form of polybags containing spinach seeds that the participants had successfully harvested to take home and cultivate in their respective homes. Assistance for the Brazilian spinach cultivation process is carried out online through the WhatsApp group social media.
Pelatihan Pengembangan Produk Kain Ulos sebagai Suvenir Khas Desa Meat Toba Samosir
Authors: Nur Christmastuti
Published: June 2022

Kementerian Pariwisata menobatkan Danau Toba di Sumatera Utara sebagai salah satu dari lima destinasi super prioritas di Indonesia. Desa Meat yang terletak di pinggir Danau Toba pun menjadi salah satu titik pengembangan wisata karena bukan hanya kaya akan keindahan alamnya namun juga masih kental unsur seni dan budayanya. Pelatihan ini bertujuan untuk memberdayakan masyarakat, khususnya ibu rumah tangga dalam mengembangkan potensi kain tenun ulos sebagai suvenir khas desa wisata Meat. Program PkM ini diawali dengan melakukan pengumpulan data melalui wawancara, survei, dan observasi dengan masyarakat dan perangkat desa setempat mengenai jenis-jenis, proses pembuatan dan pemasaran kain ulos. Tahap berikutnya adalah menyelenggarakan Training for Trainers (ToT) agar dapat mendampingi peserta dalam pelatihan. Pelatihan diselenggarakan selama 2 hari dan diikuti oleh 37 peserta. Pada hari pertama pelatihan, peserta dilatih untuk membuat kemasan dan tas belanja khusus untuk kain ulos Ragi Hotang yang yang proses penenunannya menjadi salah satu daya tarik wisata Desa Meat. Kemasan dan tas belanja merupakan salah satu upaya untuk membentuk citra merek Desa Wisata Meat yang positif. Selanjutnya pada hari kedua, peserta berlatih mengembangkan beragam produk dari kain ulos Sadum. Setelah mengikuti pelatihan ini, diharapkan masyarakat setempat dapat memasarkan produk suvenir khas Desa Meat secara langsung kepada wisatawan tanpa melalui perantara sehingga lebih meningkatkan kesejahteraan. Melalui produk suvenir ini, juga diharapkan dapat membantu mendukung kesiapan Desa Meat sebagai desa wisata.
Pelaksanaan Abdimas Edukasi Manajemen Emosi Kejiwaan Bagi Masyarakat di Kelurahan Warakas Tanjung Priok Jakarta
Authors: Dr. Elly Ingkiriwang, Sp. KJ  , Tecoalu Melitina , Fushen Fushen , Tj Hery Winoto , Setiawan Daud , Adjiputro Olga , Colline Fredella , Aprillita Dwi
Published: June 2022

Pendemi Covid-19 yang berkepanjangan hingga saat ini masih belum dianggap tuntas di negara Indonesia. Walaupun ada dampak positif yang muncul dalam kehidupan masyarakat, seperti semakin eratnya hubungan dalam anggota keluarga karena semua kegiatan ataupun aktivitas dilakukan dari rumah, yang dikenal dengan istilah kerja dan sekolah dari rumah. Namun disisi lain keberlangsungan pandemi ini menimbulkan dampak negatif bagi kehidupan masyarakat terkhusus bidang ekonomi. Ketidakmampuan masyarakat menghadapi perubahan perekonomian dapat menjadi salah pemicu gejolaknya emosi kejiwaan dalam diri seseorang di masyarakat. Apabila gejolak emosi kejiwaan kita tidak segera diatasi, kemungkinan menimbulkan depresi dan gangguan jiwa dapat muncul yang dapat berakibat terganggunya roda perekonomian negara. Karena untuk dapat berjalan dengan baik perekonomian negara dibutuhkan sumber daya manusia yang sehat secara fisik dan sehat secara rohani, dimulai dari lingkungan kecil dalam masyarakat. Untuk mengantisipasi hal tersebut perlu kepedulian dari pihak pendidikan dalam hal ini Perguruan Tinggi. Kontribusi yang dapat diberikan oleh Peruruan Tinggi adalah melakukan pelayanan dalam bentuk pengabdian kepada masyarakat melalui pemberian penyuluhan berupa informasi-informasi edukatif yang bertujuan memberikan bekal bagi masyarakat agar siap menghadapi perubahan perekonomian yang masih berlangsung hingga saat ini. Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) serta Fakultas Ekonomi dan Bisnis (FEB) UKRIDA mengimplementasikan ilmunya sesuai dengan kompetensi yang dimiliki untuk memenuhi salah satu kewajiban Tridharma Perguruan Tinggi yaitu dengan melaksanakan kegiatan pengabdian kepada masyarakat.
Applying the English Simple Code to Improve Indonesian Students’ Communicative Speaking Ability and Their Motivation
Authors: Jayaputri Herlandri Eka , Aziz MT Muhammad Fahruddin
Published: June 2022

The study aims to improve students’ communicative speaking and motivation using the simple code theory. It was action research. The research procedure consisted of identifying the students’ problems, designing the plans, applying the classroom practice expression (suitable with simple code), observing, and reflecting on each cycle. The subject was 20 students who have the lowest mark in communicative speaking ability and motivation in the pre-observation. Data were collected through observation, tests, interviews, questionnaires, and documentation and were analyzed using the descriptive quantitative, and qualitative. The English Simple Code could improve students’ communicative speaking ability and motivation in grade VIII of SMP Yapis Biak. it is also supported by the result of speaking tests and questionnaires. There are some findings; 1) implementing the classroom practice expression can help the teacher to provide a simpler language for students; 2) teacher-talk and interlanguage-talk are useful for acquiring English at the low-intermediate level; 3) emphasizing the activities of repetition drill and acting from a script can provide a prefabricated routine to prefabricated pattern and develop their fluency simultaneously; 4) teacher‘s role can improve the communicative speaking in performance; 5) delayed feedback is very useful to encourage students’ low affective filter in the learning process, so they got the high confidence and motivation in the second language acquisition. Thus, Theoretically, the English simple code can provide a good contribution to learning strategy in the classroom. Then, the teacher can use classroom practice expression, various activities, and delayed feedback to acquire English as the target language.
Language Use on Social Media: Reflection on Verbal Behavior and Cultural Identities of State Islamic University Undergraduates
Authors: Triana Hetti Waluati , Kustati Martin , Revita Ike , Peroddin David D , Faisol Yufni , Reflinaldi Reflinaldi
Published: June 2022

This study aims to identify the verbal behavior characteristics of Islamic university students with the use of Facebook in order to determine the identity forms that become a representation of their language aspects. Qualitative method was applied to objectively describe the social practices, and the varying issues and objectives of linguistic features that are generated and interpreted in these discourses. The data was procured, by using content analysis and observation, from the discourses of students at State Islamic University Imam Bonjol in the form of Facebook status posts and comments written in Facebook groups. The analysis was conducted following Fairclough’s Critical Discourse Analysis with a Critical Linguistics Approach. The results showed that the language features of the students contain some characteristics that appear in the form of abbreviations or acronyms, and the insertion of elements of foreign languages mostly dominated by features of Arabic. It was also found that the status and comments of the students focused on five dominant issues: religious, university, personal, social and cultural, and national issues. It was concluded that situational, institutional, and cultural contexts influenced the students’ production of particular discourse on Facebook. Features, issues, and discourse context identified through language used by the students had become one of many ways to recognize an Islamic university student. This ability to identify a particular student is due to the language used as a medium of communication to provide space for students to create, and directly or indirectly provide extensive information about the identity of the speakers.
FACTORS FAVOURING HELMINTHS PARASITES PREVALENCE IN PTYCHADENA MASCARENIENSIS FROM WETLAND AND FORESTS OF URBAN AND PERI-URBAN AREAS OF DALOA DEPARTMENT (IVORY COAST, WEST AFRICA)
Authors:   Laboratory of Biology and Tropical Ecology, UFR-Environment, Jean LorougnonGuede University, B.P. 150 Daloa, Ivory Coast., NGuessan Simplice Goly , NGuessan Emmanuel Assemian ,   Laboratory of Biology and Tropical Ecology, UFR-Environment, Jean LorougnonGuede University, B.P. 150 Daloa, Ivory Coast., Kary Venance Oungbe ,   Laboratory of Hydrobiology and Water Ecotoxicology, UFR-Biosciences, Felix HouphouÃ«t-Boigny University, 22 BP 582 Abidjan 22, Ivory Coast.
Published: June 2022

The period from November 2018 to June 2020 was marked by the sampling of amphibians in wetlands and forests of the urban and peri-urban areas of Daloa department. Three types of habitats were explored: urban shallows peri-urban shallows and peri-urbanizing forests. Ptychadenamascareniensis was the only one amphibian species found to be constant at the 14 sampling sites of the study area. It was therefore used to evaluate parasitic infections of amphibians in the study sites. Thus, 381 specimens of Ptychadenamascareniensis were examined and 124 were infected by helminths parasites. A total of 5 helminths species belonging to 3 classes were identified: three nematodes species: Rhabdiasbufonis Cosmocercaornata and Capillaria sp. one trematode: Haplometroideseburnense one cestode: Proteocephalus sp. Globally, prevalence of helminths parasites in the study area was 32.54%. In urban shallows, peri-urban shallows and peri-urban forests parasites prevalence was 36.08%, 34.09% and 17.46% respectively. There was a significant difference between the prevalence in shallows and forest area (Mann-Whitney test p < 0.05). In addition, parasites prevalence was favoured by two factors. They were firstly parameters with a strong positive correlation with parasites prevalence like soil cover by grasses, human pressure, water pH and water temperature, and secondly parameters with a strong negative correlation with prevalence: air temperature, canopy, litter cover, number of woody plants and relative air humidity.
ANALYSIS OF MORTALITY IN COVID 19 PATIENTS -A STUDY IN A DISTRICT COVID HOSPITAL IN ANDHRA PRADESH DURING THE FIRST WAVE
Authors:   Assistant Professor, Department of General Medicine, Dr. Pinnamaneni Siddhartha Medical College, Chinoutpally, Andhra Pradesh., Sumanth Kumar K. , Madhukiran Reddy B. ,   Associate Professor, Department of General Medicine, Dr. Pinnamaneni Siddhartha Medical College, Chinoutpally, Andhra Pradesh., Harsha NNSS ,   Senior Resident, Department of General Medicine, Dr. Pinnamaneni Siddhartha Medical College, Chinoutpally, Andhra Pradesh., Sirisha Y. ,   Associate Professor, Department of General Medicine, Dr. Pinnamaneni Siddhartha Medical College, Chinoutpally, Andhra Pradesh.
Published: June 2022

Introduction: Coronavirus disease 2019 (Covid-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Although majority of infected patients suffer from a mild form of illness and recover, a portion of patients suffer from severe disease and may eventually succumb to the illness. It has been found that risk factors like hypertension, diabetes mellitus, cardiovascular disease, cancer, COPD, asthma, chronic kidney disease, chronic liver disease ,pneumonia, obesity, and smoking were responsible for the development of the severe disease or death.Studying the common factors in patients who had mortality due to COVID 19 may help in identifying avoidable risk factors and in identifying high risk patients. Aim: To study the clinical presentation, risk factors, laboratory parameters, and treatment given to covid 19 patients who had fatal outcome. Material And Methods: This is a retrospective observational study conducted in Dr.Pinnamaneni Siddhardha institute of medical sciences and research foundation, Chinoutpally ,a district covid centre in Andhra pradesh. Baseline characteristics, clinical and laboratory data and treatment details of all mortality cases admitted during first wave i.e April 2020 to January 2021 were recorded in data collection forms and then reviewed and analysed Results: A total of 5083 patients were admitted with COVID in our hospital during the study period.114 among them had mortality accounting to about 2.24%. Male to female ratio of the mortality group was 2.8:1.Most of the patients (32.4%)belonged to the age group of 61-70 years. Hypertension (51%), Diabetes mellitus (46%),alcoholism (13.2%)and smoking(11.2%) were the most common comorbidities observed in these patients.Most of the patients (96%) had hypoxia either at the time of admission or within first two days of admission.42 patients and 17 patients required BiPAP or CPAP during their hospital stay. Conclusion: Male gender, advanced age, underlying diseases and presence of hypoxia at the time of presentation appear to be most common associations with fatal outcome of COVID 19 in the first wave in our hospital.
CORPORATE GOVERNANCE AND ENVIRONMENTAL MANAGEMENT: A STUDY OF QUOTED INDUSTRIAL GOODS COMPANIES IN NIGERIA
Authors:   Department of Entrepreneurship Studies Nnamdi Azikiwe University, Awka., Bonaventure Okolocha Chizoba , Maureen Chizoba-Okolocha Uzoamaka ,   Department of Accountancy Nnamdi Azikiwe University, Awka.
Published: June 2022

This study examined relationship between board size and environmental management of quoted industrial goods companies in Nigeria. The Ex post-facto research design was employed. A sample of twelve (12) industrial goods companies which formed the population of the study was used. Data were obtained from the sampled public quoted industrial goods companies in Nigeria for the period 2010-2019. The data extracted were analyzed using descriptive statistics, and Ordinary Least Square (OLS), statistical technique was used to test the data. Findings from the statistics revealed that board size have positive effect but this was not statistically significant on the environmental disclosure index. On the basis of the findings, it was recommended among others that governance measure of board size which was found to have positive association with environmental management need to be increased to accommodate highly experienced board members on environmental-related matters in order to make products and services of industrial goods companies more environmentally friendly.
LEG TUBERCULOSIS PRESENTING AS HYPOPION UVEITIS
Authors:   Department of Critical Care Unit and Anesthesiology, Military Hospital Instruction Mohammed V of Rabat, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Abdelhafid Houba , Nisrine Laaribi ,   Department of Ophtalmology, Military Hospital Instruction Mohammed V of Rabat, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco., Nawfal Doghmi ,   Department of Critical Care Unit and Anesthesiology, Military Hospital Instruction Mohammed V of Rabat, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Published: June 2022

We report a case of hypopion uveitis as an immune ocular reaction to pulmonary tuberculosis. This uncommon condition shouldbe considered especially in endemies areas. Quantiferon-tuberculosis Gold may be helpful to salvage such eyes by starting an appropriate treatment.
VALIDATION OF COMPASS FOR PRE-TREATMENT PATIENT-SPECIFIC QUALITY ASSURANCE
Authors:   Department of Radiotherapy, AIIMS, New Delhi-110029., Sharma Seema , Sharma Dayanand ,   Department of Radiotherapy, AIIMS, New Delhi-110029., Subramani Vellaiyan ,   Department of Radiotherapy, AIIMS, New Delhi-110029., Bhaskar Suman ,   Department of Radiotherapy, AIIMS, New Delhi-110029., Pathy Sushmita ,   Department of Radiotherapy, AIIMS, New Delhi-110029., Kumar Pratik ,   Department of Medical Physics, AIIMS, New Delhi-110029., Thulkar Sanjay ,   Department of Radio-Diagnosis, AIIMS, New Delhi-110029., Gopishankar N. ,   Department of Radiotherapy, AIIMS, New Delhi-110029., Chander Subhash ,   Department of Radiotherapy, AIIMS, New Delhi-110029.
Published: June 2022

Aim: Purpose of study is to validate COMPASS 3D patient specific quality-assurance software with Monaco treatment planning system (TPS) for routine quality assurance. Materials & methods: Purpose is to test the MLC modelling in COMPASS software, using Elekta Express QA package contains eight QA fields as follows (i) 10x10 (ii) 20x20 (iii) 3ABUT (iv) DMLC1 (v) HIMRT (vi) HDMLC(vii) 7SegA (viii) Four L were measured with COMPASS and compared with Monaco TPS. For clinical validation of COMPASS, VMAT plans were created for downloadable contoured structure set of AAPM TG119 cases for energy 6MV using Monaco (5.11) TPS for Versa-HD linear-accelerator and verified by COMPASS (calculated and measured). Results: For express QA check, all beams showed gamma pass-rate above 95% except for FourL field. FourL field Monaco versus COMPASS reconstructed gamma pass-rate was 98.4% but Monaco versus COMPASS computed gamma pass rate was 93.4%. COMPASS computed and measured, TG119 test cases showed good agreement with Monaco TPS, except some higher variation in low dose region. Conclusion: COMPASS measured (reconstructed) and computed results are in good agreement with Monaco TPS, therefore can be used for routine patient-specific quality-assurance. Special consideration has to be taken for superficially located targets.
RECONSTRUCTION OF ECONOMIC ISSUES AND CHALLENGES OF THE MUGHALS DURING THE REIGN OF AURANGZEB (1658-1707)
Authors:   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Zulfazdlee Abul Hassan Ashari Mohamad , Lubis Safian Nursafira ,   Department of Arabic Language and Literature, KIRKHS, International Islamic University of Malaysia, Jalan Gombak, 53100 Kuala Lumpur, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: June 2022

The economy was a crucial backbone in the governance of the Mughal Empire. Nevertheless, it was also an issue afflicting the stability of the empire due to the various challenges faced by its rulers during their reign, including the era of Aurangzeb (1658-1707). Military operations directed by Aurangzeb, especially to Deccan, were blamed to be the sole factor of economic crisis which happened during the period of his time. Consequent to the economic problem, Aurangzeb was forced to introduce a few appropriate measures to ensure the empires economic stability to secure the sustainability of the Mughals dominance. Based on these, this article has the objective of re-examining the economic issues and challenges of the Mughals during the era of Aurangzebs reign. In addition to that, this article also attempts to carry out a reconstruction of the economic problems in order to understand them which needed to be dealt with by Aurangzeb. This study applies a qualitative approach via historical study and content analysis of data while accumulating and analysing them based on primary and secondary sources. Results of this study showed that military expeditions during the era of Aurangzeb was collectively not the lone factor to the economic downturn of the Mughal kingdom. In fact, the economic challenges which needed to be tackled by Aurangzeb had already been in existence prior to his ascension to the throne. The economic challenges were inherited by Aurangzeb from previous administration causing him to undertake several measures to handle the economic problems in order to ensure sustainability of the empire.
IDENTIFICATION OF WEE GENES IN DICTYOSTELIUM DISCOIDEUM
Authors:   Department of Genetics, University of Delhi South Campus, New Delhi-110021, India., Lakshmi Devi Thiyam
Published: June 2022

Cell cycle is a basic cellular mechanism that allows for cellular growth and development, regeneration or repair, and wear of tissues or even regeneration of the whole organism in certain cases. A failure during the cell cycle process leads to various dire consequences. Various proteins and kinases play a vital role in the regulation of the cell cycle to meet cellular demands and needs. Amongst the kinases, Wee1 is a key regulator of cell cycle progression which inhibits mitotic entry by phosphorylating the tyrosine residue on the M-phase-inducing kinase, Cdk1, at the G2/M transition. In Dictyostelium discoideum, wee1 genes that regulate the cell cycle progression at the G2/M transition have not been identified and studied yet. Our findings support the existence of the Wee1 homolog in D. discoideum, which could play a role in cell division at G2/M.