bluuebunny/crossref_metadata_2025 huggingface dataset:
An intuitive and simplified formulation of general relativistic gravity in freely falling frames
Authors: Miller Lane R.
Published: December 2023

General relativistic gravity in freely falling frames is formulated using undergraduate calculus and matrix algebra. The key to the formulation involves retaining Newton’s first law of motion in the local spacetime of freely falling frames. The formulation shows that the relative
acceleration of two particles in the freely falling frame does not depend directly on their relative velocity. Also, the 4 × 4 matrix relating the relative acceleration of two particles to their relative spacetime displacement closely resembles the physics of Newtonian
gravity, implying that the local gravitational field obeys Laplace’s equation. The results of this paper and a previous publication [L. R. Miller, Phys. Essays 35, 202 (2022)] provide an intuitive approach that enables the use of lower-level mathematics to arrive at Einstein’s
theory of gravity in empty space.
Emergent gravity without aberration
Authors: Persson John-Erik
Published: December 2023

Gravity is explained here as a not moving phenomenon, that instead is emerging inside matter, since ether particles are assumed to be absorbed by matter (not colliding with matter). Therefore, no aberration in gravity. So, it was a great mistake to abolish Fatio’s great idea [M.
R. Edwards, Perspectives on Le Sage’s theory of gravitation, (C Roy Keys, Montreal 2002)] due to the lack of aberration in gravity. This mistake is the reason to the fact that we do not understand gravity today.
On the propagation of light and the existence of physical distances
Authors: Uğurlu Berat Tuğrul
Published: December 2023

We will show that the prepositions: Propagation of light and existence of physical distances, together form a circular reasoning fallacy. Thereby, we will claim that we do not have an implicit proof for the propagation of light and the existence of physical distances.
ChatGPT in the development of medical questionnaires. The example of the low back pain
Authors: Coraci Daniele , Maccarone Maria Chiara , Regazzo Gianluca , Accordi Giorgia , Papathanasiou Jannis V. , Masiero Stefano
Published: December 2023

In the last year, Chat Generative Pre-Trained Transformer (ChatGPT), a web software based on artificial intelligence has been showing high potential in every field of knowledge. In the medical area, its possible application is an object of many studies with promising results. We performed the current study to investigate the possible usefulness of ChatGPT in assessing low back pain. We asked ChatGPT to generate a questionnaire about this clinical condition and we compared the obtained questions and results with the ones obtained by other validated questionnaires: Oswestry Disability Index, Quebec Back Pain Disability Scale, Roland-Morris Disability Questionnaire, and Numeric Rating Scale for pain. We enrolled 20 subjects with low back pain and we found important consistencies among the validated questionnaires. The ChatGPT questionnaire showed an acceptable significant correlation only with Oswestry Disability Index and Quebec Back Pain Disability Scale. ChatGPT showed some peculiarities, especially in the assessment of quality of life and medical consultation and treatments. Our study shows that ChatGPT can help evaluate patients, including multilevel perspectives. However, its power is limited, and further research and validation are required.
Follow-up study of three cases of congenital microgastria
Authors: Ugolini Sara , Oreglio Chiara , Walsh Karl Christian , Morabito Antonino
Published: December 2023

Current knowledge on congenital microgastria is limited due to its extreme rarity, and the paucity of nutritional and quality of life follow-ups. Patients affected by congenital microgastria cases followed at out center were screened, and general and nutritional status were evaluated at follow-up visits through validated questionnaires. Three cases were included: one patient died because of a complex syndromic picture where microgastria was imperatively approached conservatively. The remaining cases underwent Hunt-Lawrence at 2 and 17 months. After 2 years and 27 years postoperatively, both patients are on full oral intake. The 28-yearold patient did not reach a BMI higher than 18. She rated her quality of life as unimpacted, with a Gastrointestinal Quality of Life Index of 111. In the other case, parents reported about their 2-yearold child an Infant Gastrointestinal Symptom Questionnaire of 13, corresponding to “no distress”. Our findings confirm the literature trend supporting the role of early surgery in microgastria to improve outcomes. We presented the nutritional status and quality of life in two cases of congenital microgastria operated according to Hunt-Lawrence at a 2-year and 27-year distance, which is the longest follow-up reported to date.
PD-L1 (SP142) Expression in Primary and Recurrent/Metastatic Triple-Negative Breast Cancers and Its Clinicopathological Significance
Authors: Han Eun Kyung , Woo Ji Won , Suh Koung Jin , Kim Se Hyun , Kim Jee Hyun , Park So Yeon
Published: December 2023

Purpose The programmed death-ligand 1 (PD-L1) SP142 assay identifies patients with triple-negative breast cancer (TNBC) who are most likely to respond to the anti–PD-L1 agent atezolizumab. We aimed to compare PD-L1 (SP142) expression between primary and recurrent/metastatic TNBCs and elucidate the clinicopathological features associated with its expression.Materials and Methods Primary and recurrent/metastatic TNBCs tested with PD-L1 (SP142) were collected, and clinicopathological information of these cases was obtained through a review of slides and medical records.Results PD-L1 (SP142) positivity was observed in 50.9% (144/283) of primary tumors and 37.8% (31/82) of recurrent/metastatic TNBCs with a significant difference. Recurrent or metastatic sites were associated with PD-L1 positivity, with high PD-L1 positivity in the lung, breast, and soft tissues, and low positivity in the bone, skin, liver, and brain. When comparing PD-L1 expression between primary and matched recurrent/metastatic TNBCs using 55 paired samples, 20 cases (36.4%) showed discordance; 10 cases revealed positive conversion, and another 10 cases revealed negative conversion during metastatic progression. In primary TNBCs, PD-L1 expression was associated with a higher histologic grade, lower T category, pushing border, and higher tumor-infiltrating lymphocyte infiltration. In survival analyses, PD-L1 positivity, especially high positivity, was found to be associated with favorable prognosis of patients.Conclusion PD-L1 (SP142) expression was lower in recurrent/metastatic TNBCs, and substantial cases showed discordance in its expression between primary and recurrent/metastatic sites, suggesting that multiple sites may need to be tested for PD-L1 (SP142) when considering atezolizumab therapy. PD-L1 (SP142)–positive TNBCs seems to be associated with favorable clinical outcomes.
The Clinical Efficacy of Colorectal Cancer Patients with Pulmonary Oligometastases by Sterotactic Body Ablative Radiotherapy: A Meta-Analysis
Authors: Jeong Jae-Uk , Rim Chai Hong , Yoo Gyu Sang , Cho Won Kyung , Chie Eui Kyu , Ahn Yong Chan , Lee Jong Hoon ,   on behalf of Korean Oligometastasis Working Group, Korean Cancer Association
Published: December 2023

PurposeThere is increasing interest in the efficacy of stereotactic ablative radiotherapy (SABR) for treating colorectal cancer (CRC) patients with oligometastases (OM), recently. The purpose of this meta-analysis was to evaluate local control (LC), progression-free survival (PFS), and overall survival (OS) of CRC patients with pulmonary OM treated with SABR and toxicities.Materials and MethodsStudies that reported SABR for CRC patients with pulmonary OM were searched from MEDLINE and Embase. Treatment outcomes including LC, PFS, OS, and toxicities of grade 3 or higher were assessed.ResultsA total of 19 studies with 1,668 patients were chosen for this meta-analysis. Pooled 1-, 2-, and 3-year LC rates were 83.1%, 69.3%, and 63.9%, respectively. PFS rates were 44.8%, 26.5%, and 21.5% at 1, 2, and 3 years, respectively. OS rates at 1-, 2-, and 3-year were 87.5%, 69.9%, and 60.5%, respectively. The toxicity rate of grade 3 or higher was 3.6%. The effect of dose escalation was meta-analyzed using available studies.ConclusionApplication of SABR to CRC patients with pulmonary OM achieved modest local control with acceptable toxicity according to the present meta-analysis. Further studies establishing the clinical efficacy of SABR are guaranteed.
The role of computed tomography for the prediction of esophageal variceal bleeding: Current status and future perspectives
Authors: Martino Alberto , Amitrano Lucio , Guardascione Marianna , Di Serafino Marco , Bennato Raffaele , Martino Rossana , de Leone Annalisa , Orsini Luigi , Romano Luigia , Lombardi Giovanni
Published: December 2023

Esophageal variceal bleeding (EVB) is one of the most common and severe complications related to portal hypertension (PH). Despite marked advances in its management during the last three decades, EVB is still associated with significant morbidity and mortality. The risk of first EVB is related to the severity of both PH and liver disease, and to the size and endoscopic appearance of esophageal varices. Indeed, hepatic venous pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) are currently recognized as the “gold standard” and the diagnostic reference standard for the prediction of EVB, respectively. However, HVPG is an invasive, expensive, and technically complex procedure, not widely available in clinical practice, whereas EGD is mainly limited by its invasive nature. In this scenario, computed tomography (CT) has been recently proposed as a promising modality for the non-invasive prediction of EVB. Although CT is only a diagnostic modality, thus being not capable of supplanting EGD or HVPG in providing therapeutic and physiological data, it could potentially assist liver disease scores, HVPG, and EGD in a more effective prediction of EVB. However, to date, evidence concerning the role of CT in this setting is still lacking. Our review aimed to summarize and discuss the current evidence concerning the role of CT in predicting the risk of EVB.
In search of the better? The representations of Utopia and dystopia in Kofi Awoonor’s This Earth, My Brother…
Authors: Osei-Poku Kwame , Ankomah Edmund H.
Published: December 2023

This paper is informed by the extensive corpus of African postcolonial critique that examines the after-effects of empire in ex-colonial societies. Thus, in the studied engagement of the Ghanaian ex-colonial state, this paper turns to Awoonor’s This Earth, My Brother..., read as one of such commentaries on the rusted, conscienceless ex-colonial nation and the tones of negative burdens laid on citizens’ existential quest for selfhood, self-actualisation and the assertion of identity. In such a circumstance, one may be lost between the real world and a wishful world; the real being the present state of affairs and the wishful being that for which they yearn. Through critical reading and analysis, we discuss the representations of utopia and dystopia in This Earth, My Brother..., in the light of the myriad features that these concepts offer. The paper argues that the extradiegetic Ghanaian nation has much to learn from Awoonor’s diegetic lifeworld.
3D BASKILI BETON KOMPOZİT DUVAR PANELLERİNİN STANDART YANGIN KOŞULUNDAKİ DUVAR İÇ YÜZEY SICAKLIK DEĞİŞİMİNİN BULANIKLAŞTIRILMASI
Authors: PAKDAMAR Ferhat , KAPLAN Şevval , COŞGUN Nilay
Published: December 2023

Yapı sektöründe 3 Boyutlu baskı (3DP) teknolojisi, potansiyel avantajları nedeniyle hızlanan bir büyüme performansı sergilemiştir. Sektöre hızlı giren bu teknoloji birçok açıdan incelenmiş olup, yangına karşı olan yalıtım performansının da incelenmesi gerekmektedir. Yapılan çalışmalarda 3D basılı beton (3DPC) duvarlar için, yangın performansına ilişkin ayrıntılı bir araştırma gerekli olduğu belirtilmektedir. Literatür taraması sonucunda Sonlu Eleman Modelleri (FEM'ler) kullanarak yapılan detaylı bir çalışma incelenmiş. Çalışma sonucunda elde edilen verilerin bilinmeyen ara verilerini insan düşünme sistemine yakın bir yöntem olan bulanık mantık ile tespit etmek için bulanık küme yöntemi ile model geliştirilmiştir. Çalışmanın üç farklı konfigürasyonunun yoğunluktaki girdi ve çıktı verileri kullanılmıştır. Her bir yoğunluk ve duvar konfigürasyonu için kurallar oluşturulmuştur. Oluşturulan modelden elde edilen verilerle tablo ve grafikler oluşturularak ara veriler belirlenmiştir. Analiz ve bulgular bağlamında çalışmaya konu duvar konfigürasyonlarının yangına karşı dayanım verimliliği incelenmiştir. Analizlerin sonuçlarına göre, duvar konfigürasyonları kütle performansı açısından C1, CI1 ve S4 şeklinde sıralanırken, yalıtım performansı açısından ise CI1 ve S4 konfigürasyonlarının C1'e göre daha fazla kazanç sağladığı belirlenmiştir.
The Perception of the Syrian Asylum Seekers in Turkey: Sentiment Analysis with Twitter Data
Authors: Parlak İlhan , Çakın Ömer
Published: December 2023

This study examines the perception of Syrian refugees who have migrated to Turkey within the Turkish public. For this purpose, the reasons for Syrian refugees’ migration to Turkey, their population in Turkey, their distribution in Turkey, their education status and enrollment rates, their working lives, their impact on the economy, the aid provided to them, their impact on public services and security in Turkey were investigated. Subsequently, sentiment analyses were conducted based on machine learning approaches on Twitter to measure the perception of the Turkish public regarding Syrian refugees. Perception was examined in three different dimensions: general perception, the nature of perception, and the reasons behind perception. In this context, tweets related to Syrian refugees posted throughout the year 2021 were collected, pre-processed, and transformed into a format suitable for data mining algorithms. Some of the tweets were manually classified according to the machine learning technique, and the remaining tweets were automatically classified by algorithms determined, taking into account the manually made classifications. As a result, it was determined that the general perception of the Turkish public regarding Syrian refugees on Twitter is largely negative and characterized by ‘discontent’. The main reasons behind this perception were found to be the perceived harm caused by Syrian refugees, their high numbers, and perceptions that they are better off than the locals, primarily due to their refugee and residency rights.
Cultural Indicators of New Generation Journalism Practices Implemented by Transnational News Agencies in Turkey in the Context of Earthquake Reporting
Authors: Yetimova Serhat
Published: December 2023

This study investigates how the transnational news agencies BBC, The Voice of America, Sputnik, Euronews and Al Jazeera Turk, which broadcast in Turkish that use new generation media tools by focusing on the news they developed about earthquakes in Turkey. Using the thematic content analysis method, the article compares new generation media theory and disaster journalism with practical applications and reaches conclusions involving a number of cultural differences. The main problem of the research is that earthquake reporting in Turkey is not effective enough in the national press. The aim of the study is to determine which applications are used by the news agencies that make effective earthquake reporting by using new generation media tools in the earthquake processes. The transnational news media active in Turkey produced news about the earthquake in a wide variety of contexts. When I consider the thematic contexts it is seen that city culture, preventive policies, building technology, education, psychological and sociological causes and effects often coexist. It is also seen that transnational news agencies play an important role in raising the phenomenon of journalism with a high level of political engagement in Turkey to a level of professionalism that takes care of the public interest.
British Political Rhetoric in the Perspective of Cultural Specificity
Authors: Aleshina Ekaterina Yu. , Golova Daria D.
Published: December 2023

Existing research in the field of political communication and rhetoric often focuses on general principles and strategies of the speech, leaving aside cultural-specific considerations. This study is aimed at analyzing the discursive characteristics of British public political rhetoric, which will fill this gap and expand knowledge about the relationship between language, culture, and politics. The work aims to identify the discursive features of the British public political speech from the perspective of its cultural specificity. The results of the study show that, despite the universal nature of the public political rhetoric, British public political speeches differ in certain specifics. The speeches of British politicians are marked by features characteristic of each type in the structure of the text, the use of vivid rhetorical techniques, strict adherence to the protocol, emphasis on the sense of national pride, as well as some unique attributes. This study provides a deeper understanding of the role of language and cultural factors in political communication, and it is also able to expand the theoretical foundations in the field of linguistics and political science.

The article is intended for researchers and specialists in the field of linguistics, rhetoric, and political communication. It can also serve as a useful resource for students, postgraduates, and teachers interested in a detailed analysis of the discursive characteristics of British political rhetoric.
Post-secular Religiosity and Sport: Football as Religion
Authors: Poliakov Nikolai S.
Published: December 2023

The passion for sports sometimes takes on such hypertrophied forms that it actually turns out to be one of the variants of religion, fulfilling a number of its significant functions. Football, like few other modern phenomena, demonstrates a close connection to religion, usually with prefixes like “pseudo”, “para”, or “quasi”. In the conditions of post-secularism, when primary institutions, such as religion, lose their initial importance, secondary institutions may begin to play the role of the primary ones. And in this context, we can talk about football as a secular religion. The article examines the ritual origins of the ball game in Mesoamerica and China, the history of football formation in England and the role of priests in this process, various forms of mythological thinking manifestation among football players and coaches, and idolatry on the example of invented religions (the Church of Maradona and the Church of Football). As a result, we can come to the following conclusion: football, at least, functionally replaces religion, which is well seen in the example of England, where football identity is sometimes more important than religious one. The results of the study contribute to better understanding of the features of contemporary religiosity, the so-called religion-like phenomena, and may be of interest to a wide range of readers: religious scholars, historians, sociologists and philologists.
A (des)regulamentação estatal e a busca pela segurança das barragens de rejeitos da mineração
Authors: Do Nascimento Passos Alexandra , Ferreira Soares Christiane Júlia
Published: December 2023

Os crimes ocorridos com barragens de rejeitos em Mariana e Brumadinho, no estado de Minas Gerais, expuseram o perigo destas estruturas de contenção. A atividade da mineração é altamente lucrativa, mas impacta negativamente os territórios nos quais é realizada. De um lado, para auferir lucros cada vez maiores, as mineradoras optam pelas barragens de rejeitos com menor custo, menosprezando assim a segurança. Por outro lado, o Estado, ao atuar com omissão ou dubiedade na edição de leis e ao omitir-se no rigor da fiscalização das atividades mineradoras, contribui para que seus riscos sejam aumentados. Desta forma, populações que vivem nas proximidades das barragens de rejeitos vivem sem o devido apoio estatal na prevenção de riscos. O objetivo do presente artigo é analisar como a gestão social pode contribuir com o desenvolvimento local nos territórios de mineração possibilitando a construção de uma comunicação entre sociedade, estado e empresas. A partir da revisão de literatura, o estudo revelou que, na perspectiva da gestão social, o fortalecimento das relações sociais e o envolvimento de diversos atores da sociedade civil por meio da participação é o caminho para a construção de uma mineração responsável e segura, que tenha como propósito o desenvolvimento local.
Conflitos ambientais, usos e gestão dos bens da União
Authors: Gomes Fernando Soares , Castilho Ela Wiecko Volkmer de , Thé Ana Paula Glinfskoi
Published: December 2023

Conflitos ambientais, usos e gestão dos bens da União foi uma proposta de reunião de pesquisas oriunda de uma inquietação comum dos organizadores acerca de problemáticas interdisciplinares, que perpassam contextos específicos, nos quais grupos sociais com modos diferenciados de apropriação, usos e significação da natureza protagonizam disputas em torno de bens imóveis da União; e igualmente a gestão institucional desse patrimônio (ACSELRAD, 2004).
De la sacralidad de la naturaleza a la del hombre. La transformación de la religiosidad durante la Edad Media
Authors: Tavelli Federico
Published: December 2023

Este artículo se concentra en el proceso de transformación de la religiosidad cristiana durante la Edad Media entre los siglos XI y XV. Muestra cómo la religiosidad, ancestralmente ligada al valor de la tierra y a los ciclos de la luz comienza a cambiar a medida que el hombre logra obtener otros medios de subsistencia centrados en la valoración de su propia capacidad humana. Los cambios demográficos, económicos, políticos y sociales desempeñan un rol central, y la religiosidad se mueve al mismo ritmo que estos factores. La autonomía respecto de los señores feudales, el auge de las ciudades libres, la producción artesanal y el comercio influyen notablemente en la comprensión y expresión religiosa que se centra en las capacidades humanas. El artículo intenta que el lector pueda comprender el movimiento y los principales componentes de este proceso a través de algunos ejemplos tomados de distintas áreas geográficas. La cultura medieval, y, por tanto, la religiosidad, continuarán su camino de transformación. Las necesidades y tensiones irresueltas del período que se expresan a través de la idea de reforma de la Iglesia nos sitúan en la antesala del surgimiento de las confesiones en el siglo XVI, donde éstas encuentran nuevos canales de expresión.
Preferencias y valores en el cuidado en el final de la vida. Aportes para la reflexión
Authors: Radosta Darío Iván , Mazzini María Marcela
Published: December 2023

Este trabajo expone un relevamiento y estudio realizado por el grupo de Investigación de la Facultad de Teología de la UCA que trabaja prácticas de espiritualidad en el final de la vida. Llevamos adelante una encuesta a nivel nacional en la cual relevamos las preferencias y valores en el cuidado en el final de la vida de las personas frente a un caso hipotético de enfermedad que amenazase su integridad, al mismo tiempo que tomamos en cuenta algunas variables sociodemográficas fundamentales con el objetivo de poder correlacionar su respuesta con las características específicas de cada población encuestada. Luego de contextualizar el trabajo y exponer la metodología utilizada, se presentan los resultados globales de la encuesta y de algunos temas en particular, reflexionando sobre los mismos y planteando en la conclusión algunos límites y posibilidades de la presente investigación.
La Teología en la formación de la conciencia histórica
Authors: Galli Carlos María
Published: December 2023

La conciencia histórica es un factor fundamental en la construcción de una iden-tidad. Un rasgo del individualismo posmoderno es la pérdida del sentido de la historia y la reducción de la conciencia al presente: el hoy, el momento, el instante. Esto sucede en todo el mundo en virtud de la contemporaneidad alcanzada por los medios de comunicación y las redes sociales, y se agrava por la falta de perspecti-vas y proyectos para el futuro, lo que crea incertidumbre y angustia.Esta meditación sigue cuatro momentos. En el primero, se apunta a renovar nues-tra conciencia histórica poniendo el foco en la trama temporal de la vida personal y comunitaria (I). En el segundo el autor despliega varias relaciones entre la his-toria humana y la fe cristiana, prestando una atención principal al cristocentrismo de la historia (II). En la tercera sección se señala la novedad de la irrupción de la historia en la teología del siglo XX (III). Al final se presenta el fundamento his-tórico que guía a la Facultad de Teología e indica tres novedades puntuales que expresan la dimensión histórica en las tareas que hacemos para alcanzar los fines de la institución: investigar, enseñar y difundir la teología (IV). Se trata del texto completo, revisado y actualizado del discurso del decano Pbro. Dr. Carlos María Galli pronunciado el 16 de marzo de 2023 al abrir el Año Académico en la Facultad de Teología de la Pontificia Universidad Católica Argentina.
¿Transubstanciados? Esbozos eucarísticos de una antropología en clave sinodal
Authors: Bertolini Alejandro
Published: December 2023

La sinodalidad puede abordarse desde distintos ámbitos. Estas líneas proponen centrar la mirada en su declinación antropológica, cuyo núcleo se encuentra en el exacto cruce de la escatología y la eclesiología. A partir de la asociación identitaria con la eucaristía, jugaremos con los distintos elementos que constituyen lo que podríamos llamar una antropología sinodal: eucaristía, tensión escatológica, ser para la comunión y el cuerpo de Cristo como ámbito propio de la “subsistencia” propia de la nueva creatura.
Into the Unknown: Navigating Orbital Cellulitis to Reveal Retinal Metastasis of a Hidden Primary Tumor
Authors: Abu-Rumaileh Mohammed , Patel Kashvi , Ashgar Fahham , Garg Anu
Published: December 2023

Introduction

This is a rare patient presentation of retinal metastasis with an unknown primary tumor.

 

Case Presentation

A 65-year-old woman with a past medical history of left breast carcinoma stage 1 status post left mastectomy in 2014, iron deficiency anemia, anxiety, and depression presented to the emergency department with 1-2 weeks of worsening lower abdominal pain and left-sided chest pain. She also complained of right eye pain, blurry vision, and painful eye movement. Ocular examination demonstrated edema, mild proptosis, conjunctival chemosis, and conjunctival injection. Patient was started on bacitracin ointment and ceftriaxone due to concerns of orbital cellulitis. Ophthalmology was consulted, and their assessment was suggestive of bilateral metastatic neoplastic lesion in retina of both eyes, more pronounced in the right than the left eye. Left supraclavicular lymph node biopsy showed metastatic adenocarcinoma, likely of gastrointestinal or pancreaticobiliary primary. MRI brain was suspicious for calvarial metastatic disease, MRI abdomen showed multiple nodules in the liver suggesting metastases, and whole-body nuclear medicine bone scan suggested possible metastases in the hemithorax and bilateral femurs. After several goals of care discussions, the decision was made by the patient and her family to pursue comfort measures only and she was discharged home with home hospice and later passed away.

 

Conclusion

Retinal metastasis is a rare condition due to the absence of lymphatic system in the eye (1). The most common primary tumors to metastasize to the eye are from breast (47%), lung (21%), and the gastrointestinal tract (4%) (2). In some cases, patients may have no other symptoms (1). Thus, retinal metastasis is important to include in the differential diagnosis, especially for patients with a history of treated primary cancer.
Treprostinil inhibits functional activation of scleroderma (SSc) vascular smooth muscle cells (vSMCs) by inhibiting Yap and activating PPARG signaling.
Authors: Wang Yongqing , Kahaleh Bashar
Published: December 2023

Background:

Progressive vascular wall thickness and fibrosis are the hallmarks of SSc vasculopathy. Overexpression of TGFB1 in SSc and activation of vSMCs are important steps in the pathogenesis of SSc vascular disease.

Objectives:

 In this study, we examined the expression levels of COL1, PCNA, PFKP, IP, EP2, IP, and PTGIS in SSc skin, the effects of Treprostinil (prostacyclin analog) on cell proliferation, TGFB1-induced collagen expression in SSc-vSMCs, PPARG expression and Yap nuclear translocation.

Methods:

SSc and control skin biopsies were fixed and 10uM serial sections were cut for histological examination.  vSMCs were isolated from involved skin and matched healthy subjects. The expression and distribution of collagen, PCNA, PFKP, IP, EP2, PTGIS, PPARG, and Yap were measured by immunohistochemical staining or immunofluorescent staining. Cell proliferation was measured by MTT assay.  The mRNA expression levels were detected by qPCR.

Results:

The protein expression levels of collagen, PCNA, PFKP, and EP2 were increased, while the expression levels of PTGIS and IP were decreased in vSMCs of SSc-skin, compared to the control. These results suggested that defective PGI2-IP signaling in SSc-vSMCs may contribute to vessel wall thickness and vascular fibrosis in SSc. Treprostinil inhibited vSMCs proliferation, COL1A1, and PFKP mRNA expression in SSc-vSMCs in a dose-dependent fashion. Treprostinil also inhibited TGFB1-induced COL1A1 mRNA expression in SSc-vSMCs via engagement of EP2. The PPARG expression was significantly increased in treprostinil-treated SSc-vSMCs. Treprostinil decreased the nuclear location of YAP which is induced by 10%FBS and TGFB1.

Conclusion:

Defective PGI2-IP signaling in SSc-vSMCs is associated with enhanced expression of collagen, PCNA, and PFKP in SSc vessel walls. The antiproliferative and antifibrotic activity of treprostinil is mediated through the inhibition of YAP nuclear translocation and enhanced PPARG expression. YAP and PPARG might be promising therapeutic targets for the treatment of SSc-related vasculopathy.
POTENTIAL FOR DEVELOPING INDIVIDUAL START-UP BUSINESS MODELS FROM INDIGENOUS PRODUCTS: CASE STUDY OF KUMQUAT PRODUCTS IN CAM HA - HOI AN
Authors: Thanh Tung Hoang , Bao Tran Nguyen
Published: December 2023

Cam Ha, Hoi An considered the “capital” of kumquats in the Central region with unique artistic shapes of kumquat trees by leading artisans of Cam Ha ornamental kumquats. Cam Ha kumquat trees have brought a significant source of income to local people and contributed to making the scent of Vietnamese spring days even more brilliant. The article examines the potential for developing individual startup business models on the basis of some typical examples of implementing the Kumquat startup model in Cam Ha - Hoi An. Besides, the article also mentions the difficulties for the startup model of trading products from Cam Ha Kumquat and proposes solutions to develop the startup business model from Kumquat in Cam Ha - Hoi An.
AN IN DEPTH ANALYSIS ON HOW TO INCREASE FARMERS INCOME IN THE DISTRICT OF KARNAL, HARYANA THROUGH DAIRY FARMING
Authors: Gupta Haardik
Published: December 2023

The research uses primary data to analyse the income generated from dairy farming in the district of Karnal, Haryana. Are the farmers totally dependent on dairy farming? Has dairy farming over the years become an important source of income? Are there government schemes that can enhance dairy production? Are the farmers aware of such schemes? These and similar such types of questions will be attempted in the course of the paper.
EFFECT OF PHTHALATES ON MENTAL HEALTH, REPRODUCTIVE SYSTEM AND ENDOCRINE SYSTEM
Authors: Jain Adishri
Published: December 2023

Phthalates is the common term used to describe a group of chemicals also called plasticisers as they help increase the durability of plastics and don't mix with the chemicals of the plastic. They pollute the surrounding environment by mixing with dust and air. This article will describe the effects of Phthalates on human life and the reproductive system, on the ecological balance of nature, the mental health and brain function of individuals, and on the endocrine system. We also highlight areas that need more primary research to understand a causal relationship between them, and how this chemical easily gets concealed under other names.
INVESTIGATING THE COMBINED EFFECTS OF HEAVY METALS COPPER AND ZINC ON OXIDATIVE STRESS LEVELS OF LYMNAEA STAGNALIS
Authors: Vemareddy Saanvi
Published: December 2023

Biodiversity, the variety of life within a particular ecosystem or habitat, has been a growing concern in freshwater ecosystems. Streams become more polluted as a result of industrial and agricultural runoff, specifically through heavy metals found in industrial waste as well as pesticides. The impact of pollution on stream health could be studied through bioindicator macroinvertebrates, as their health and mortality reflects the quality of their environment. If an a bioindicator organism’s environment were in poor health conditions, it would reflect on the organism by creating health issues and defects. This study aims to determine the combined effects of heavy metals Copper sulfate and Zinc nitrate on stream health through investigating the oxidative stress levels of macroinvertebrates Lymnaea stagnalis. This involved exposure of Lymnaea stagnalis to the following experimental groups: 15 g/L Zinc nitrate, 15 ug/L Copper sulfate, and regular pond water that will be created in the lab. The disparity between oxidative stress levels of each group would be evaluated. This would be done through a thiobarbituric acid reactive substances assay, which measures the creation of lipid peroxidation products that result from oxidative stress. The creation of lipid peroxidation products indicates oxidative stress through producing a pink color, which will be measured through aspectrophotometer. Additional work is needed to corroborate preliminary results and draw final conclusions. This study may be able to support the creation of new water treatment methods through evaluating the extent to which heavy metals play a significant role in water pollution.
A Review of Vedic Mathematics for the Design of High-Speed Arithmetic RISC Processors
Authors: Singh Thakur Dharmendra , Kumar Shah Sunil
Published: December 2023

Vedic Mathematics is a collection of techniques and concepts developed from ancient Indian mathematical books known as the Vedas. These strategies are designed to make different mathematical computations easier and faster. High-throughput RISC Processor Design, on the other hand, includes the creation of processors that prioritize the execution of a high number of instructions per unit of time. If there have been breakthroughs relating to Vedic Mathematics and High-Throughput RISC Processor Design, it would be intriguing to investigate how these old mathematical ideas may be utilized to improve the efficiency of current processor designs. Give a summary of the work, stressing the potential benefits and drawbacks of incorporating Vedic Mathematics concepts into the design of High-Throughput RISC computers. Introduce Vedic Mathematics and High-Throughput RISC Processor Design separately. Explain briefly why you're looking at incorporating Vedic Mathematics into CPU architecture. Outline key Vedic Mathematics concepts that may be applied to processor design. What distinguishes these ideas from typical mathematical approaches Provide an overview of the fundamental ideas and issues involved in the design of high-throughput RISC processors. Emphasize the critical areas for improvement and integrating principles from Vedic Mathematics into Processor Architecture: Investigate the use of Vedic Mathematics principles in processor architecture to discuss how these concepts may be utilized to solve specific problems or improve aspects of high-throughput RISC architectures. The importance of multipliers in Arithmetic Unit performance is underlined. The incorporation of Vedic Science, an ancient mathematical system comprised of 16 Sutras, implies a fresh method for arithmetic computations. The suggestion comprises optimizing the Vedic multiplier type Urdhva Triyakbhyam by substituting Convey Save Viper for the usual carry. This is done to reduce delays caused by standard adders and incomplete products aspire to outperform traditional designs in terms of speed. The explicit data on the speed gains is obtained and how they were assessed will bolster the claims and utilization of the proposed proficient Vedic multiplier in the number juggling module of the RISC processor. In addition, stating its application in the field of digital signal processing (DSP) broadens the scope of work. Validation of RTLs and FPGAs for the Register-Transfer Level (RTL) implementation of the proposed Math Unit in VHDL, paired with simulation using Xilinx ISE EDA tools, is a useful step in verifying the design. Validation on an FPGA device, especially a Vertex-IV, provides credibility to the suggested solution.
Design and Implementation of High Speed and Area Optimized Vedic Processor for Embedded Systems
Authors: Singh Thakur Dharmendra , Kumar Shah Sunil
Published: December 2023

The proposed work on the design and implementation of a High-Speed and Area-Optimized Vedic Processor for Embedded Systems appears promising. Here's an outline that we might find useful for organizing our work. Discuss briefly the growing need for high-performance embedded systems and the crucial role of processors. Summarize prior research on Vedic Processors, highlighting major features and optimizations gained by earlier researchers. The exact Vedic mathematics ideas and sutras that we propose to exploit in our processor design. Detail tactics for obtaining high-speed operations in the CPU, taking into account parallelism, pipelining, and other optimization approaches. As the computational complexity of tiny battery-powered devices develops, this study addresses the need for a fast 16-bit RISC processor. The emphasis is on boosting processor capabilities by integrating a Multiply-Accumulator (MAC) unit based on Vedic mathematics. The inclusion of a new instruction set involves VHDL-based changes to the processor's architecture, to ensure simplicity and total compatibility with the current structure. This study describes an innovative strategy for enhancing the capabilities of modest 16-bit RISC processors by including a Vedic mathematics-based Multiply-Accumulator (MAC) unit. The objective is to improve processor functionality by providing a new instruction set, which will be performed through VHDL-based changes to the CPU's design. The newly designed instruction set keeps its structure basic, ensuring complete compatibility with the previous architecture. A 16-bit pipelined system based on Harvard design has several components in its pipeline, comprising register access, arithmetic execution, front-end logic execution, instruction fetch, and decode. The simulation results demonstrate the validity of the proposed design, demonstrating effective verification and synthesis of the MAC architecture on an FPGA platform.
Uso de mamografías asistidas por la IA para la detección de cáncer de mama
Authors: Velasco Vargas Frank Alexander , Cuasapaz Pisco Vanessa Isabel , Araujo Sandoval Orlen Ismel
Published: December 2023

La medicina es un campo en donde la tecnología es una herramienta de gran utilidad que abarca el uso de diferentes enfoques de inteligencia artificial, utilizados para la detección de cáncer de mama proporcionando un impacto significativo en la salud y en la lucha contra esta enfermedad. Utilizando una metodología descriptiva-explicativa y técnicas de documentación con el fin de obtener información relevante y detallada sobre esta enfermedad basada en mamografías asistidas por inteligencia artificial. Según la Organización Mundial de la Salud el cáncer de mama es una enfermedad que afecta al tejido mamario en la cual aparecen células mamarias anormales que crecen fuera de control y forman tumores. Si no se controlan, los tumores pueden extenderse por todo el cuerpo y llegar a ser mortales. Esto puede tanto al sexo femenino en donde el factor de riesgo más fuerte de cáncer de mama. Aproximadamente entre el 0,5 y el 1% de los cánceres de mama se producen en hombres. Exponiendo los avances de nuestro entorno que busca la prevención o detección a tiempo del cáncer de mama con el uso de la IA.
Ciberseguridad en la Era de la Inteligencia Artificial
Authors: Eras Chancay Steeven Xavier
Published: December 2023

La ciberseguridad se ha transformado significativamente en las últimas décadas gracias a la Inteligencia Artificial (IA). Esta evolución ha mejorado la capacidad de las organizaciones para proteger sus activos digitales, pero también ha introducido nuevos desafíos. La IA ha demostrado ser una herramienta valiosa en la ciberseguridad al permitir la detección avanzada de amenazas, la automatización de respuestas y el análisis de comportamiento. Además, la IA aprende y se adapta continuamente, lo que asegura que las defensas cibernéticas estén actualizadas. Sin embargo, la integración de la IA en la ciberseguridad también conlleva desafíos, como la posibilidad de que los atacantes utilicen la IA para crear ataques más sofisticados y la preocupación por la privacidad y la ética en la manipulación de datos personales. Además, los errores y sesgos en los algoritmos de IA deben ser abordados, al igual que la escasez de profesionales capacitados en ciberseguridad. Las tendencias futuras incluyen un mayor uso del aprendizaje profundo en seguridad, la automatización de respuestas más avanzadas y una mayor atención a la privacidad de los datos. La colaboración entre la industria y la investigación será esencial para abordar los desafíos emergentes relacionados con la IA en la ciberseguridad. La interacción entre estos dos campos continuará evolucionando en la búsqueda de un futuro digital más seguro.
Neurociencia, atención plena y plasticidad cerebral: un enfoque integral para la optimización de la enseñanza y el aprendizaje en la educación académica y cotidiana
Authors: Renteria Valencia Nuvia
Published: December 2023

Este artículo analiza la convergencia de la neurociencia, la atención plena y el concepto de plasticidad cerebral desde un enfoque holístico para mejorar tanto la enseñanza como el aprendizaje en contextos académicos y cotidianos. Se exploran las teorías y contribuciones fundamentales de Jon Kabat-Zinn, Marian Rojas-Estapé, Nazaret Castellanos y los estudios de Ramón y Cajal, resaltando cómo estas perspectivas influyen en la planificación curricular, las estrategias de enseñanza y las evaluaciones educativas.
Capacitación al personal de salud para conocer los reglamentos y estatutos de un hospital
Authors: Reyes Pinto Katherine Gabriela , Cedeño Silvestre Luis Adrian
Published: December 2023

Las condiciones laborales de los profesionales de medicina están siendo un factor de relación al valorar la sobrecarga de trabajo debido a la gran exigencia en las áreas de cuidados al paciente por ser de gran complejidad y al existir déficit de personal. El objetivo es determinar la sobrecarga de trabajo en el personal de salud del hospital general Santo Domingo de los Tsáchilas. Debido a todo este conjunto de requerimientos psicofísicos, psicológicos a los que se ve sometido el personal a lo largo de su jornada laboral, debe cumplirlas por encima de las cuales el trabajador puede tener consecuencias negativas. Esta es una investigación cuantitativa, descriptiva, transversal, observacional y retrospectiva. Para su aplicación se realizó encuestas y entrevistas al personal de salud, director y jefes de áreas. Del análisis se obtuvo que el nivel de sobrecarga laboral es medio-bajo, y se identificó una presencia de la extensión de horario de trabajo que sugiere indicios de sobrecarga laboral. Con el cual se concluyó que la sobrecarga tiene una relación importante con el compromiso hacia los pacientes, en el cual a mayor sobrecarga laboral es menor el compromiso con el paciente. Finalmente se presento una propuesta al director del hospital de utilizar un gestor de proyectos y tareas, para llevar a cabo una tarea a la vez y así dar una mejor calidad en la atención de los servicios de salud.
Students’ Optimal Engagement in EFL Large Classes: A Qualitative Phenomenological Study in East Nusa Tenggara
Authors: Nurak Siwa Yohanis , Basthomi Yazid
Published: December 2023

In recent years, there has been an increasing interest in researching students’ engagement in English as foreign language (EFL) classes as students’ language learning achievement is shaped by their engagement in class. Yet, the study of students’ engagement in EFL large classes has received relatively little empirical attention. This qualitative phenomenological study aims at exploring how teachers perceive the factors boosting students’ optimal engagement and what strategies they use to boost students’ optimal engagement in EFL large classes. Ten university teachers with adequate experience of teaching EFL large classes in East Nusa Tenggara-Indonesia participated in this study. Semi structured interviews were used to elicit the teachers’ perceptions and interpretations of students’ optimal engagement. The results revealed five factors affecting students’ optimal engagement in EFL large classes: teaching strategies, individual motivation, student-teacher relationship, students’ English proficiency, and teaching facilities. Additionally, the teachers applied instructional and affective strategies to boost students’ optimal engagement in EFL large classes. Based on the study results, we offered some pedagogical implications for the teachers and their institutions.
Unpacking Online Collaborative Learning in Teaching EFL Speaking: Insights from Three Rural Area Case Studies
Authors: Butarbutar Ranta , Ruing Fentry Hennaing , Basri Nurfajriah , Tuharea Varissca Utari , Radja Leba Seli Marlina
Published: December 2023

The collaborative use of technology and online teaching and learning is a new pedagogical trend following the spread of the COVID-19 pandemic in 2020. This pedagogy has created flexible learning modes for teachers and students to practice and develop their speaking skills in English as a foreign language through collaborative activities, interactive group projects, and peer feedback. Despite the plethora of studies pertinent to online learning, online collaborative learning (OCL) insights in rural areas are not well-documented, leaving knowledge gaps. Thus, a study of teachers' and students' perceptions of OCL in rural areas of Papua, Indonesia, is needed. Researchers have confirmed that the OCL is a new pedagogical approach to lifelong and sustainable learning. This study employed a qualitative report, using a triple-case study approach. The results propose that: (1) OCL can be implemented using two learning modes: synchronous and asynchronous. The WhatsApp group (WAG) chat feature was used to deliver written discussions and peer evaluations and the WhatsApp voice note tool to provide oral feedback synchronously. Google Classroom asynchronously provided the materials, tasks, and teacher feedback. (2) Teachers’ reasons for choosing OCL in EFL speaking courses include effectiveness, efficiency, interest, and engagement. Students’ perceptions highlighted the OCL effect in light of three aspects: (a) social, (b) psychological, and (c) speaking skills. (3) Teachers’ barriers during OCL implementation: (a) poor internet connection, (b) free-riders, (c) unpunctuality, and (d) unfamiliarity with technology use. (4) Teacher strategies to overcome the barriers to OCL: (a) university-sponsored internet, (b) OCL orientation at the beginning of class, (c) forming groups and choosing topics regarding students’ prior knowledge, (d) extra peer tutoring time, and (e) self-directed learning.