bluuebunny/crossref_metadata_2025 huggingface dataset:
RESEARCH OF CONSUMER LOYALTY LEVELS IN STRATEGIC ACTIVITY ON THE EXAMPLE OF PJSC «OTIS»
Authors: Ovsiienko Nataliia
Published: June 2021

As of 2018, in the Ukrainian market, 90% of companies use loyalty programs in their activities. Among them 42% have developed and develop programs for more than 5 years [1, c.7]. However, there is a recognition of the importance of developing the loyalty of consumers as a component of the marketing activity of the enterprise, there are open the problem of the existence of a comprehensive approach to managing the loyalty program based on the theoretical approach, and not on practical experience of bonus and discount programs. In a pandemic, many enterprises understand that consumers will easily go to competitors in the absence of loyalty. And loyalty is acquired by the functioning of the effective process of managing loyalty program.
Almost 50% of Ukrainian companies noted that the management of loyalty is engaged in sales department [1]. As a result, half enterprises are not aware of the importance of marketing activities in managing loyalty program. Thus, the costs of marketing communications are not consistent with the objectives of the loyalty program. This leads to the fact that it will not receive the desired economic results and the level of loyalty, which determined the relevance of the topic.
In addition, rapid changes in the Ukrainian market on the side of Digitalization affects the development of loyalty programs. This is a development of chat bots to reduce the costs of communication channels, consumer identification via Wi-Fi and Bluetooth for an instant special offer depending on their geoposition. Continuing to use irrelevant loyalty programs for the market, the enterprise may encounter negative consequences: a decrease in loyalty, profitability, loss of competitive positions.
Typically, those enterprises that are classified as large or have opportunities for significant financial investments in loyalty program, use terminal networks and applications. Also, the formation of customer bases and the creation of an appropriate proposal to each becomes automated by using CRM systems.
Loyalty program is a unique tool in marketing activity, since it may be used at all stages of enterprise development, forms a relationship with consumers and reflects their behavior and the product needs. And the main thing is that it creates a loyal consumer who brings profit by the enterprise.
MANAGEMENT APPROACHES TO SUPPLY LOGISTIC OPTIMIZATION
Authors: Ovsyanyuk-Berdadina Oleksandra
Published: June 2021

Modern realities of enterprises operation actualize the need to optimize logistics chains by intensifying administration actions of managers to detail logistics expenditures and automate the business process. At the same time, the functional focus of the company's interaction with partners in supply logistics is to perform tasks aimed at minimizing logistics costs. Minimization of logistics costs, as well as the introduction into management practice of other principles of logistics (timeliness of deliveries, assurance of quality and declared deadlines) creates additional competitive advantages of the enterprise and optimizes its entire business process.
Under these conditions, the issue of management approaches is actualized, which makes it possible to increase production flexibility, adapt the enterprise to competitive conditions, optimize flow processes, integrate elements of the production management system, ensure maximum capacity of production facilities, optimize basic and auxiliary operations, manufacture products in accordance with existing orders and fully meet the expectations of the main stakeholders of the enterprise. The vector of application of management approaches should be based on definite, specific for a particular business unit, measurable parameters of operating activities, which would be indicators of overall performance of the enterprise and informationally integrate the effectiveness of logistics and operating systems as a whole.
The article proposes a methodical approach to the formation of a system of indicators for a comprehensive assessment of raw material procurement (cost of the procurement process; quality of raw materials; the degree of satisfaction of final users) as well as an algorithm for their calculation. The practical significance of calculating such indicators is the synthesized application of indicators of efficiency of logistic and production systems of the enterprise as a whole, as well as the application of differentiated assessment of significance of indicators according to the established rating scale depending on the functional orientation of purchased products for the production process.
FORMATION OF THE ENTERPRISE COMPETITIVE POTENTIAL
Authors: Seleznova Halyna
Published: June 2021

The article presents the results of the research on the essence of the enterprise "competitive potential" concept and the definition of its structural components. It’s been proved that the creation and maintenance of the competitive potential of the enterprise directly depends on its management system, which makes it necessary to consider the potential of the enterprise as a set of the management subject potential and production potential (potential of the management object). Choosing the growth trajectory of the enterprise is impossible without assessing the development adequacy of the components of its potential, for which different methods and indicators can be used. In addition, the build-up process should take into account the chosen strategy, the implementation of which is based on the availability of a sufficient level of certain components of the potential. This necessitates the coordination of potential building processes, creating competitive advantages and implementing the company's strategy. It’s been proposed to form the competitive potential of the enterprise based on the assessment of the strategic gap. The contradictions of the process of managing the competitive potential of the enterprise have been determined and the influence of personnel resistance to changes in the process of transformations has been considered. There has been developed a scheme of the process of forming of the enterprise competitive potential which foresees the following blocks: development of the enterprise strategy, creating the program of measures for reduction possible resistance, identification of measures on transformation of production potential and increasing administrative potential, assessment of activities priority and sequence formation of the organization competitive potential, development and implementation of the comprehensive program for the formation of the organization competitive potential. The advantage of the proposed scheme is the achieved consistency of potential building processes, creation of competitive advantages and implementation of enterprise strategy. The proposed approach is aimed to resolve the contradictions that arise in the process of managing the competitive potential of the enterprise, which provides an opportunity to qualitatively and timely implement a strategy aimed at enterprise development.
MANAGEMENT OF EFFICIENCY OF SMALL BUSINESS ENTERPRISES
Authors: Turchina Svetlana , Dashutina Liudmyla
Published: June 2021

This article is devoted to the problems of managing the company’s efficiency of small business enterprises. It is proved that small business is one of the leading sectors of market economies because it solves important problems such as: employment, providing the market with various goods and services, and so on. The article clarifies the definition of enterprise efficient management, according to the authors, the most acceptable for small businesses. Such definition interpreted as a process based on management functions and takes into account the tools and methods of management decision-making, the formation and distribution of profits, and the rational use of all available resources to maximize financial results and optimize financial resources.
Detailed research was conducted on the materials of small business representative - a limited liability company "VVM Trading" (Sumy). The main problems in its activity are revealed in the article. Among such problems, the authors highlight the low ability of the enterprise management system to ensure the implementation of such basic functions as: analysis, forecasting, planning, and hence - operational regulation of the situation in the environment. On the example of a specific small business entity, the authors argue that the efficiency of economic activity of the enterprise is fully amenable to management actions based on certain principles and scientific approaches.
It is established that in LLC "VVM Trading" the entrepreneur combines the main functions of managing the efficiency of economic activity of the enterprise, as in most small enterprises. Optimization of the management structure is proposed on the example of the basic enterprise. Also it has been proven that a financial management specialist with a clearly defined range of responsibilities should professionally carry out the management process to manage the efficiency of economic activity. It is important to use economic and mathematical methods for analytical work, planning and forecasting of key economic indicators in order to improve the enterprise efficient management.
SYNERGETIC ROLE OF RECREATIONAL CYCLES IN HUMAN CAPITAL REPRODUCTION AND TOURIST SPHERE DEVELOPMENT IN THE CONDITIONS OF SOCIALLY ORIENTED ECONOMY
Authors: Khytra Olena
Published: June 2021

The view that the successful development of tourism in the country is an important prerequisite for the formation of a socially oriented market economy and contributes to the reproduction of human capital has been substantiated in the article. The social essence of tourism, which is manifested in universal accessibility, democracy, humanization, as well as the implementation of the principles of partnership and intercultural interaction has been revealed. The role of recreational activities and, accordingly, the quality of recreational needs of each person in the reproduction of human capital has been substantiated. Based on the results of the study of social, economic, geographical and environmental aspects of recreational zoning, a conclusion has been made about the need to diversify the spatio-temporal combinations of recreational activities in recreational cycles. As the formation of recreational needs is influenced by a large number of interrelated (and sometimes contradictory) factors, it is advisable to use a nonlinear approach to develop a program to meet them. In addition, recreational activities take place in a non-linear recreational environment, which is a combination of natural and anthropogenic elements, the interaction of which can cause both favorable and negative effects on the results of planned and amateur recreational activities. It has been proved in the article that recreational cycles are formed on a synergetic basis: the dominance of the principles of self-organization at the personal level is balanced by coordinating measures at the social level. It has been suggested to supplement the system of concepts of recreational activities with the term "recreational time management", which is appropriate to denote a system of organizational, economic and socio-psychological measures aimed at creating conditions for optimal distribution of time between different recreational activities within the cycle of recreational activities. the vacationer to restore his own physical and spiritual strength as soon as possible. The use of time management techniques in combination with the principles of recreational zoning will ensure the achievement of optimal spatial and temporal indicators of recreation. The synergy of combining tourism and recreation in the context of increasing social and economic effects with a simultaneous reduction of the recreational loading on the natural complex has been substantiated.
FISCAL FUNCTION OF CUSTOMS POLICY AS AN IMPORTANT COMPONENT OF ENSURING THE EFFICIENCY OF ITS MECHANISM FORMATION
Authors: Buhel Yuliia
Published: June 2021

The article considers the essence of customs policy as a set of measures taken to ensure the most effective use of instruments of customs control and customs regulation of foreign economic activity, aimed at maintaining a positive trade balance of the country and the development of the national economy. It is noted that the state's customs policy is designed to promote the country's economic security, which will guarantee a sufficient level of socio-economic and defense existence, as well as the political independence of its economic interests in relation to possible external and internal threats and influences. In this context, the author emphasizes that the profound political, economic and social processes taking place in Ukraine today have determined serious changes in the understanding of the role and importance of the state's customs policy.
It is studied that at the present stage of development of the national economy, customs policy as an integral part of public policy has a pronounced fiscal nature. Accordingly, it is emphasized that this definition of priorities is primarily caused by the problem of acute budget deficit, which is complicated by the problems of tax evasion, significant external debt and the state of social guarantees of the state.
As conclusions, it is stated that the basis for the transformation of customs in Ukraine should be the transition from the customs service as an exclusively fiscal body that provides most of the tax revenues of the state budget to the controlling body, whose main purpose is to ensure compliance with Ukrainian legislation on customs. At the same time, it was emphasized that the role of control in modern conditions will be not only in a comprehensive assessment of the sphere of taxation of foreign economic activity, but also in identifying additional sources of filling the budget through effective management decisions. However, it is emphasized that the fiscal orientation of the customs service of Ukraine today is primarily due to the state of our economy. Therefore, fundamental changes in the conduct of customs affairs of Ukraine and its tasks are possible only with a corresponding change in the economic situation in the country.
ANALYSIS OF THE STRUCTURE AND DYNAMICS OF COSTS IN THE EDUCATIONAL AND METHODOLOGICAL CENTER OF CULTURE
Authors: Romankova Oksana , Glushchenko Irina
Published: June 2021

The article analyzes the structure and dynamics of costs of the Municipal Institution of Culture "Donetsk Regional Educational and Methodological Center of Culture" in Kramatorsk. Accounting in budgetary institutions is a system of control over the availability and movement of budgetary and extrabudgetary funds, is based on generally accepted principles, performs management, information, control functions and has certain features. The main purpose of the Center is to train and improve the staff of clubs, educational institutions of culture and art, parks of culture and recreation, tourism, the introduction of new forms of management, conducting various cultural and artistic events and growth of artistic creativity. Thus, most of it is allocated to the costs associated with the provision of services and the purchase of materials and equipment for cultural and artistic events. The organization has established a memorial-order form of accounting using the software package "Athens: Salary" and "Fit-budget" to account for records of business transactions in the accounting registers. When determining the amount of expenditures, budgetary institutions should take into account the objective need for funds, based on their basic production indicators and contingents set for institutions, the amount of work performed, staffing, the need for individual programs and planned measures to reduce expenditures in the planning period.
All expenditures included in the draft estimate must be substantiated by appropriate calculations for each economic classification code. This means that when drafting the budget, budget institutions provide a detailed breakdown of expenditures for each code of economic classification of expenditures to justify the amount of expenditures. The purpose of the analysis of the implementation of cost estimates is to assess the effectiveness of the allocated material, labor and financial resources, identify deviations of actual expenditures from the estimated allocations, as well as quantify the impact of factors that caused these deviations. It is the analysis of the structure and dynamics of expenditures of the educational and methodical center of culture will help to study in detail the main expenditures of the budget organization.
TAX OFFENSES: THE ESSENCE AND CLASSIFICATION FEATURES
Authors: Sirenko Olena
Published: June 2021

An analysis of the operational situation in the field of paying taxes and carrying out entrepreneurial activity indicates that tax crime reaches a qualitatively new level, turning into one of the main threats to the state economic security, since it is the economic basis for the existence of organized criminal groups. Such offenses are massive and organized.
Any activity of business entities is related to the payment of taxes. The duty of subjects, as taxpayers, is to calculate, declare and pay the amount of tax and due within the established time frame. The article summarizes the main elements of tax debt: tax accounting and payment of taxes and fees.
The article summarizes scientific approaches to defining the essence of the concept of "tax offenses". It has been established that the following signs are inherent in the tax offenses: the presence of financial and legal responsibility for violation of tax legislation; social harm, which is expressed in the violation of subjective rights and legal obligations or obstruction of their implementation. The essence of the concept of "social harm" also consists in the ability to threaten with causing socially harmful consequences or their assignment to objects of financial and legal or tax and legal protection. Not every act can be recognized as a tax offense, entailing socially harmful consequences in the field of tax discipline protection, but only an act that violates the norms of tax legislation that establish tax obligations and prohibitions. Only acts that entail the occurrence of guilt should be recognized as a tax offense. This issue requires detailed scientific research in order to formulate a “model of guilt” that will be suitable for further consolidation in tax legislation. Punishments are applied to acts that are characterized by all the signs of a tax offense. Measures of financial and legal responsibility are provided for these actions in tax legislation.
The article summarizes scientific approaches to the definition of the classification signs of tax offenses and their types. The types of liability (administrative and financial) have been systematized according to the main types of tax offenses.
PROBLEMS OF FORMATION OF INVESTMENT POTENTIAL OF THE NATIONAL ECONOMY
Authors: Shaposhnykov Kostiantyn
Published: June 2021

The article reveals the peculiarities of the formation of investment potential of the national economy. It is substantiated that in the conditions of decentralization of power and finances there is a need for structural changes and diversification of economic activities not only at the state level, but also at the local and meso levels. It is proved that the investment potential is associated with national wealth and gross domestic product. It has been found that the largest share of fixed assets of Ukraine is concentrated in industry. As a result of the research, it is proved that in terms of assessing the investment potential through the national wealth and fixed assets of Ukraine, industry is the dominant imperative, which should be considered transport with related economic activities and administrative support services. It is justified that the revealed dynamics of the recession of the industrial sector of the Ukrainian economy has taken place in combination with the deterioration of price dynamics in key commodity markets of national exports. It is proposed to improve the position of Ukraine in world markets, it is necessary to intensify cooperation between business (owners), government and civil society in the development and adoption of national and territorial program documents.
ANALYTICAL EVALUATION OF FINANCIAL ASSETS OF ENTERPRISES
Authors: Volkova Nina , Kravets Daria
Published: June 2021

The article facing attention to the importance of the presence of current assets at the enterprise, as an element of its solvency and profitability. The essence of financial assets is revealed and the importance of their distinguishing from a part of current assets for a more detailed and clear analysis of the enterprise. The dynamics and structure of the main elements of financial assets of enterprises of various branches of the economy of Ukraine and the Odessa region are analyzed. Attention is drawn to the growing role of financial assets in enterprises, since they affect the level of solvency and financial sustainability of the enterprise. During the period of 2015-2019, agricultural and industrial enterprises of Ukraine and the Odessa region suffered significant changes in the structure of assets. Analysis of the structure of assets of CJSC "State Food-Grain Corporation Corporation of Ukraine" and PJSC "Odessa Cable Plant" Odeskabel "for the period 2015-2019 showed that the enterprises there is a logical tendency for the distribution of working capital and non-current assets according to their sectoral affiliation. The analysis showed that in the assets of agricultural enterprises of mobile assets is almost twice as low as in real assets. In industrial enterprises, the distribution in the structure of assets has also been formed with exceeding the share of current assets by 10 percentage points. Financial assets were analyzed as elements of current assets on investigated enterprises in 2015 -2019. Conclusions on the tendency of increasing this element of current assets, as receivables, two terms - cost and its share. In the analysis of financial assets of the state joint-stock company "State Food-Grain Corporation" of Ukraine ", attention was paid to such an element Finance. Once assets as current financial investments. This is an important part of financial assets, but they are not present at each enterprise. It has been analyzed that their share for 2015-2018 was constantly fluctuating. If in 2017, their share was 73% of all oblast assets, then in 2019 at the investigated enterprise they did not have become, but, at the same time, cash and their equivalents have increased. We considered it expedient to pay attention to this process.
Application of Bayesian Networks of Genotype by Environment Interaction Evaluation Under Plant Disease, Soil Types and Climate Condition-using Bayesia Lab
Authors: Omer Siraj Osman
Published: June 2021

Genotype by environment interaction (GEI) linked to plant disease, soil properties and climate conditions add potential value for a breeding program to underpin decision making. In understanding genotype x environment interaction, the most challenging factors are the identification of genetic variation for a range of traits and their responsiveness to the climate change factors. In order to study the complex relationships with genetic and non-genetic factors, the application of Bayesian network tools will help understand and accelerate plant breeding progress and improve the efficiency of crop production. In this study, we proposed the application of Bayesian networks (BNs) to evaluate genotype by environment interaction under plant diseases, soil type, and climate variables. An adapted to simulate multiple environmental trial (MET) data of maize (corn) was used to examine the performance of the BN predictive modeling using BayesiaLab for deriving knowledge and graphical structure for exploring GEI diagnosis and analysis. The results highlighted that genotypes have the same probability and the frequentist of rainfall, temperature, soil type, and disease type occurred as <=88 (46%), 35 (37%), clay (27%), and MB (47%) respectively, which have to monitor reflects in each discretization. This study provided a roadmap to knowledge modeling of GEI using BayesiaLab software. On a broader scale, this study helps predict the yield of crop varieties by understanding agronomic and environmental factors under farm conditions rather than conducting long-term agricultural testing under well-controlled conditions of the on-station trials. Future improvements of BNs application of METs should consider working on a larger and more detailed soil and irrigation system linked to agro system.
Oral actinomycosis in Crohn’s disease patient: a case report
Authors: Huynh Trong Nguyen Dang , Pham Quyen Thi Trieu , Pham Thong Quang , Ho Phat Tan
Published: June 2021

Patients with Crohn’s disease may present with lesions in their oral cavity. Oral lesions may be associated with the disease itself representing an extraintestinal manifestation, with nutritional deficiencies or with complications from therapy including infections. Actinomycosis is a slowly progressive bacterial infection caused by Actinomyces spp., anaerobic Gram-positive bacteria. These organisms are normal inhabitants of mucous membranes, especially of the oropharynx, and cause opportunistic infections. We report a case of a 30-year-old male with Crohn’s disease presenting with painful oral aphthous ulcers and swelling of the upper lip. A diagnosis of oral actinomycosis was confirmed by histopathological examination. The patient was treated with infliximab and a regimen of amoxicillin 1 g three times a day. He had a marked response to the treatment after 2 weeks. The plan was to continue amoxicillin for at least 6 months with regular follow-up. Physicians should be aware that actinomycosis may be a cause of oral lesions in Crohn’s disease patient, particularly in immunosuppressed patient. Bacterial cultures and pathology are the cornerstones of diagnosis and should be performed in suspected cases to prevent misdiagnosis.
Psychometric properties of Body Mass Index in screening malnutrition of COPD inpatients admitted at Nguyen Tri Phuong Hospital, Vietnam: a cross-sectional study
Authors: Truong Uyen Phuong , Pham Lan-Anh Thi , Huynh Van-Anh Ngoc , Tran Thi Van , To Kien Gia
Published: June 2021

This study assessed the validation of Body Mass Index (BMI) against Subjective Global Assessment (SGA), and identify the prevalence of malnutrition and its associated factors in Chronic Obstructive Pulmonary Disease (COPD) inpatients at Nguyen Tri Phuong Hospital, Ho Chi Minh City, Vietnam.

A cross-sectional study was conducted to consecutively select COPD inpatients based on medical records and consultancy with doctors. A structured questionnaire was designed to collect socio-demographic characteristics, health status and comorbidities, nutritional status, and handgrip strength. Nutritional status was assessed using SGA and BMI. Handgrip strength was measured using a hand dynamometer. Health status was collected from medical records.

The mean age of 83 COPD inpatients recruited in this study was 67 (SD=10.4) years. Most of the sample population was ≥60 years old (75%), male (86%), Kinh ethnic (89%), married (72%), not currently working (70%), and less than junior high school (81%). Nearly 68% had at least one comorbidity and 27% were active smokers. The mean handgrip strength was 21.6 kg (SD=8.7), and mean weight was 53.9 kg (SD=10.0). The mean BMI was 20.4 kg/m2 (SD=3.4) with 58% having BMI <21 kg/m2. SGA provided the prevalence of malnutrition of 65%. Age-group, BMI and handgrip strength were associated with malnutrition. A BMI cut-off point of <21 kg/m2 provided the highest ROC area of 84% (95%CI: 76%-92%).

Malnutrition is common in COPD inpatients. This study confirms findings of previous studies that a BMI cut-off point of <21 kg/m2 was sensitive and specific for screening malnutritional risk at bedside.
PEMANTAUAN DAN MITIGASI TINGKAT POTENSI BENCANA KEKERINGAN DI KOTA DUMAI
Authors: Arya Eggy , Safitri Yuliana , Riyadhno Fitrah Andika
Published: June 2021

Kekeringan lahan yang terjadi saat musim kemarau memberikan dampak buruk bagi vegetasi, salah satunya tanah Gambut sangat sensitif terhadap kenaikan suhu menimbulkan kebakaran hutan. Kota Dumai menjadi salah satu daerah yang sering mengalami kebakaran hutan dan lahan, efek terjadi kebakaran  ini menjadikan lahan tersebut memiliki kualitas yang menurun meliputi fisika, kimia, dan adanya erosi  tanah. Dalam tulisan  ini, kami memantau adanya peningkatan dan penuruan dalam beberapa kategori kekeringan lahan. Adapun parameter yang digunakan seperti vegetation health index (VHI), vegetation condition index (VCI), dan temperature condition index (TCI) pada tahun 2013 dan tahun 2018. Hasil penelitian menjelaskan wilayah kekeringan mengalami kenaikan total selama periode pengamatan sebesar 23.119 hektar lahan, dengan kategori tanpa kekeringan terjadi penurunan seluas 23.119 ha, kemudian kategori kekeringan ringan  terjadi peningkatan seluas19.510 ha, selanjutnya kategori kekeringan sedang terjadi peningkatan seluas 13.444 ha, lalu kategori kekeringan parah terjadi penurunan seluas 9.163 ha, dan kekeringan ekstrim  mengalami penurunan seluas 672 ha. hal ini sejalan dengan terjadinya kenaikan pada suhu tahun 2013 mencapai 38 ºC  kemudian mengalami peningkatan menjadi 47,53ºC di tahun 2018 yang sedang mengalami kebakaran hutan dan lahan
水利施工中碾压混凝土施工技术研究
Authors: 赵 汇鑫
Published: June 2021

近年来，在多方面利好因素的影响下，我国社会经济水平得到了显著的提升，从而有效的推动了民众生活水平的提升，为了更好的满足社会发展和民众生活对水资源的需求，大量的水利工程应时而生。碾压混凝土其实质就是属于干硬性贫水泥混凝土，借助各类原始材料以及附加剂，按照一定的比例进行混合之后配置出来的混合材料，借助专业的运输和施工机械设备，运用振动分层压实的方法来进行工程的建造。碾压混凝土施工技术要想保证实践运用的效果，那么还需要对施工要求加以全面的了解，结合实际情况从各个细节入手来对施工周期以及工程成本加以把控，保证水利工程项目的整体收益。
水利工程施工技术存在的问题及对策
Authors: 朱 奎衡
Published: June 2021

在社会快速发展的带动下，我国各个行业的发展都取得了良好的成绩，从而为水利工程行业的发展带来了诸多的机遇。但是就当前我国水利工程施工技术实际情况来说，整体水平还么有达到成熟的状态，其中还存在诸多的问题需要我们加以切实的解决，这样才可以保证水利工程能够满足社会发展的实际需要。鉴于此，这篇文章主要围绕水利工程施工技术展开全面深入的分析研究，希望能够对我国水利工程行业的未来稳步持续发展有所帮助。
水利工程管理中的问题与对策
Authors: 马 文生
Published: June 2021

近年来，在多方面利好因素的影响下，我国社会经济水平得到了全面的提升，从而为各个领域的发展壮大带来了良好的机遇，有效的推动了水利工程行业的不断发展。水利工程不但与社会发展密切相关，并且也与民众的生活息息相关，所以需要施工单位从各个细节入手来对水利工程施工质量加以保证，全面的落实各项施工管理工作，对水利工程施工工作的实施给予良好的辅助。但是就现如今水利工程管理工作实际情况来说，整体水平并没有达到成熟的状态，其中还存在诸多的问题需要我们加以切实的解决。水利工程往往涉及到大量的施工环节，只有保证良好的管理效果，才能确保各项工作能够按照既定的计划有序的开展。利用系统化的管理工作，不但可以提升水利工程的施工效率，引导施工单位树立良好的安全施工理念，还可以切实的规避各类危险事故的发生，促进水利工程综合性能的不断提升，为我国社会经济的良好发展起到积极的辅助作用。
沿海高腐蚀地区金属结构防腐施工实践-温州市瓯飞一期围垦工程闸门防腐工艺
Authors: 周 毓 , 郑 斌 , 陈 丽霞
Published: June 2021

温州市瓯飞一期围垦工程属于淤涨型高涂围垦，海堤及水闸迎水面结构处于海水浪溅区或盐雾作用区，潮湿并有严重侵蚀性介质作用，海水环境下的钢闸门及埋件由于受到水压、水流冲击和阳光、水生物等的影响，极易被腐蚀并降低钢闸门的承载能力和安全性能，对设备的抗腐蚀性能提出了非常高的要求。文中从闸门及埋件的新材料选用、防腐涂料的选择、防腐施工的工艺及措施、取得的效果等方面阐述了在沿海高腐蚀地区的金属结构防腐施工实践。
The High Price of Sedentary Behaviour
Authors: Amin Md Nurul
Published: June 2021

Abstract not availableIbrahim Cardiac Med J 2015; 5(1-2): 5-8
Abordagem teórico-prática da dermatite herpetiforme como a principal manifestação cutânea da doença celíaca: Revisão integrativa
Authors: Holanda Sarah Maria Monteiro Soares Costa de , Nunes Raíssa Martins de Oliveira , Silva Larissa Alves dos Santos , Barros Marianna Mendes de , Silva Pedro Henrique Freitas , Assunção Anna Joyce Tajra , Moura Adhonias Carvalho , Galvão Evandra Marielly Leite Nogueira Freitas
Published: June 2021

Introdução: A dermatite herpetiforme (DH) é uma manifestação benigna, crônica e inflamatória da pele. As lesões são erupções eritêmato- pápulo- vesiculosa, pruriginosas, simétricas, dispostas de forma herpetiforme, tendo afinidade por superfícies extensoras. Há predileção pelo sexo masculino, entre 30 e 40 anos e está relacionada com anormalidades na mucosa do intestino delgado e ao depósito de IgA na derme papilar. Tem origem multifatorial, abrangendo componentes genéticos, ambientais e imunológicos. Objetivos: Analisar a aplicação dos conhecimentos obtidos pela revisão integrativa abordando a dermatite herpetiforme e doença celíaca (DC) para elaboração de um raciocínio clínico frente ao diagnóstico precoce e tratamento efetivo. Metodologia: Artigos científicos e de revisão publicados e referenciados no MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA/RedTESA e MEdCArib foram consultados, delimitados de 2008 a 2019. Os livros “Tratado de dermatologia” de Belda Júnior e “Dermatologia” de Sampaio e Rivitti também foram incluídos. Resultados: O diagnóstico da DH é clinico, laboratorial e imunológico. A apresentação e atividade de erupção das bolhas é variável. O achado histopatológico clássico é uma fenda subepidérmica com neutrófilos e eosinófilos nas papilas dérmica, com infiltrado inflamatório misto perivesicular. A imunofluorescência direta da pele não envolvida é padrão ouro.O pilar do tratamento envolve uma dieta livre de glúten associado ao uso de medicamentos, sendo observada a remissão incompleta frequente em pacientes que não restringem o glúten. Conclusão: O conhecimento das manifestações clínicas e subclínicas da DH e DC assim como achados laboratoriais são cruciais ao diagnóstico precoce, corroborando para afastar diagnósticos errôneos, exacerbações ou complicações.
Law, the Humanities and Political Incertitude in a Time of Climate Change
Authors: Nicolini Matteo
Published: June 2021

This article addresses how climate change triggers relevant transformations in the realm of the law and affects our politico-legal paradigms. To this end, it delivers cross-disciplinary research by focusing on a non-fictional literary genre, i.e. climate-change pop-science, which has arisen very recently. The article also explores the concept of ‘strategic formalism’, i.e. a strategic legal device unable to govern societal concerns. On the one hand, it shapes our approach to climate change and migration; on the other, it adapts ecological issues to the ‘traditional’ legal framework. Against this background, the article argues that non-fictional texts also reflect the ideas of the most active forces within society, and fuel dynamism when tackling the ecological crisis. In a time of climate change, these forces stir strategic formalism, and make the law act as a bridge linking our troubled reality to an inclusive future.
Natural History Dioramas: An opportunity for children to observe physical Science in action in a moment of time
Authors:   University of East London, Cass School of Education and Communities, Gkouskou Eirini , Tunnicliffe Sue Dale ,   University College London, Institute of Education
Published: June 2021

Î¤he natureofscientificresearch goes beyond the learning of concepts and basic manipulation to the key factors of engaging students in identifying relevant evidence and reflecting on its interpretation. It is argued that young children have the ability to acquire viable realistic concepts of the living world when involved in relevant activities (Tunnicliffe, 2000). Visiting a museum of natural history is an educational experience, which offers, children experiences that cannot be obtained within the classroom and research found that museums are excellent sources of cognitive experiences that complement and / or enrich the curriculum of formal education (Dillon et al., 2016). Dioramas have specific context, which give visitors the opportunity to be creative and have more learning opportunities when they engage with them (Achiam et al., 2014). This paper draws upon data that were gathered at a natural history museum. These data were the spontaneous conversations of child visitors and a workshop with structured educational activities with a pre- and post-test research design, which provided the opportunity for children to observe Science in action in a moment of time. These data focused on aspects of historical and experimental aspects of Science in action shown in the positions and environments of the animals featured which may be identified in natural history dioramas.
Gender and Polish family discourse in adult education:
Authors: Ostrouch-Kamińska Joanna
Published: June 2021

The main aim of the paper is to reconstruct the family discourse in adult education in Poland in the context of the gender research perspective present in this discourse. The narrative starts from an analysis of the family as a place of informal learning and the family research in adult education, as well as family learning/informal learning of adults in a family, to come to an analysis of the gender approach in adult education and gendered learning of adults, as well as researching gender in the Polish family discourse present in adult education. In reference to the latest literature and analyses of different contexts of family research in adult education, both international and Polish, at the end the author presents a small part of the findings from the biographical research it was conducted on a dual-career family and the process of constructing gender equality in marriage as an example of gendered family discourse in adult education.
Correlation Between SARS-Cov-2 Vaccination, COVID-19 Incidence and Mortality: Tracking the Effect of Vaccination on Population Protection in Real Time
Authors: Fukutani Kiyoshi F. , Barreto Mauricio L. , Andrade Bruno B. , Queiroz Artur T. L.
Published: June 2021

Coronavirus disease 19 (COVID-19) has struck the world since the ending of 2019. Tools for pandemic control were scarce, limited only to social distance and face mask usage. Today, upto 12 vaccines were approved and the rapid development raises questions about the vaccine efficiency. We accessed the public database provided by each country and the number of death, active cases, and tests in order to evaluate how the vaccine is influencing the COVID-19 pandemic. We observed distinct profiles across the countries and it was related to the vaccination start date and we are proposing a new way to manage the vaccination.
Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study
Authors: Pérez-Sáez María José , Uffing Audrey , Leon Juliette , Murakami Naoka , Watanabe Andreia , Borges Thiago J. , Sabbisetti Venkata S. , Cureton Pamela , Kenyon Victoria , Keating Leigh , Yee Karen , Fernandes Satiro Carla Aline , Serena Gloria , Hildebrandt Friedhelm , Riella Cristian V. , Libermann Towia A. , Wang Minxian , Pascual Julio , Bonventre Joseph V. , Cravedi Paolo , Fasano Alessio , Riella Leonardo V.
Published: June 2021

Kidney disease affects 10% of the world population and is associated with increased mortality. Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage kidney disease in children, often failing standard immunosuppression. Here, we report the results of a prospective study to investigate the immunological impact and safety of a gluten-free and dairy-free (GF/DF) diet in children with SRNS. The study was organized as a four-week summer camp implementing a strict GF/DF diet with prospective collection of blood, urine and stool in addition to whole exome sequencing WES of DNA of participants. Using flow cytometry, proteomic assays and microbiome metagenomics, we show that GF/DF diet had a major anti-inflammatory effect in all participants both at the protein and cellular level with 4-fold increase in T regulatory/T helper 17 cells ratio and the promotion of a favorable regulatory gut microbiota. Overall, GF/DF can have a significant anti-inflammatory effect in children with SRNS and further trials are warranted to investigate this potential dietary intervention in children with SRNS.
Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots
Authors: Furesi Giulia , Fert Ingrid , Beaufrère Marie , Araujo Luiza M. , Glatigny Simon , Baschant Ulrike , von Bonin Malte , Hofbauer Lorenz C. , Horwood Nicole J. , Breban Maxime , Rauner Martina
Published: June 2021

Bone marrow adipose tissue (BMAT) has recently been recognized as a distinct fat depot with endocrine functions. However, if and how it is regulated by chronic inflammation remains unknown. Here, we investigate the amount of white fat and BMAT in HLA-B27 transgenic rats and curdlan-challenged SKG mice, two well-established models of chronic inflammatory spondyloarthritis (SpA). Subcutaneous and gonadal white adipose tissue and BMAT was reduced by 65-70% and by up to 90% in both experimental models. Consistently, B27 rats had a 2-3-fold decrease in the serum concentrations of the adipocyte-derived cytokines adiponectin and leptin as well as a 2-fold lower concentration of triglycerides. The bone marrow of B27 rats was further characterized by higher numbers of neutrophils, lower numbers of erythroblast precursors, and higher numbers of IL-17 producing CD4+ T cells. IL-17 concentration was also increased in the serum of B27 rats. Using a cell culture model, we show that high levels of IL-17 in the serum of B27 rats negatively impacted adipogenesis (-76%), an effect that was reversed in the presence of neutralizing anti-IL-17 antibody. In summary, these findings show BMAT is severely reduced in two experimental models of chronic inflammatory SpA and suggest that IL-17 is involved in this process.
Case Report: Rhizopus arrhizus Rhino-Orbital-Cerebral Mycosis and Lethal Midline Granuloma: Another Fungal Etiological Agent
Authors: Li Dong Ming , Lun Li De , Ge Jie , Zhang Gong Jie , Li Xin Lun , de Hoog G. Sybren
Published: June 2021

Objective: Both rhino-orbital-cerebral mycosis and lethal midline granuloma (LMG) may result in midline destruction. LMG has now been generally considered as a natural killer/T cell lymphoma, nasal type (ENKTL-NT) with an association of EBV. Fungi have been detected from the diseased tissues now and then but are often considered as lymphoma-associated infections. We previously reported an ENKTL-NT case with Mucor irregularis, which played a causal role in the disease and was involved in the overexpression of Ki67 and CD56 in the mouse experiment. The present study describes a chronic Rhizopus arrhizus infection with immunological parameters that are closely similar to LMG. We aim to explore the relationship of another Mucorales fungus, R. arrhizus, and LMG in a patient and in mice.

Methods: Case study and mouse infection modules were designed for our observation. A 35-year-old man with midline face ulcers which was clinically suspected as LMG was selected. Biopsy specimens were sent for lymphoma diagnosis and microbiological detection. The isolated fungus was tested in an ICR mouse model for mycological and histological analyses.

Results: Five tissue samples yielded Rhizopus arrhizus. In the pathology, characteristic inflammation, necrosis, and granulation with thin-walled hyphae are observed. Immunohistochemistry showed NK/T cell infiltration (CD3+, CD8+, TIA1+, GZMB+, PRF+, individual CD56+) with hyperplasia (Ki67+) and angioinvasion. The patient recovered completely with amphotericin B. In the murine experiment, R. arrhizus caused angioinvasion with NK/T cell infiltration (CD3+, CD56+, TIA1+, GZMB +, PRF+) with proliferation (Ki67+) and was re-isolated from the infected host.

Conclusions: We here describe a mid-face destruction patient, which was diagnosed by the top pathologists in China according to the current criteria of NK/T cell lymphoma, with a negative result for EBV and positive result for R. arrhizus. With a then developed mouse experiment, the R. arrhizus in the diseased lesions was responsible for the NK/T cell infiltration (CD3+, CD8+, CD56+, TIA1+, GZMB+, PRF+), proliferation (Ki67+), and angioinvasion, suggesting another fungal etiological agent for LMG, which could be eradicated with amphotericin B.

Limitations: The sample size is not sufficient for statistical analysis. However, our findings are suggestive for the role fungus plays in LMG.
Risk of Inflammatory Bowel Disease Following Appendectomy in Adulthood
Authors: Chung Wei-Sheng , Chung Sunny , Hsu Chung-Y , Lin Cheng-Li
Published: June 2021

Background: The appendix has a complicated immune function, and appendectomy may derange the immune system. Studies on the relationship between appendectomy and subsequent inflammatory bowel disease (IBD) have been inconsistent. We conducted a nationwide cohort study consisting of individuals who underwent appendectomy to evaluate the incidence and risk of ulcerative colitis (UC) and Crohn's disease (CD).

Methods: We identified patients aged >20 years who underwent appendectomy between 2000 and 2012 from inpatient claims of the National Health Insurance Research Database (NHIRD) and assigned them to the appendectomy cohort. Then, we randomly selected patients without appendectomy in the NHIRD and assigned them to the comparison cohort in a frequency-matched 1:1 ratio based on sex, age, and index year. We tracked down all participants until IBD diagnosis, death, or the end of 2013. Cox models were used to estimate the hazard ratio (HR), and 95% confidence intervals (CIs) were used to compare the IBD risk between the appendectomy and comparison cohorts.

Results: The appendectomy and comparison cohorts in the study consisted of 246 562 patients each. The appendectomy cohort exhibited a 2.23- and 3.48-fold higher risk of UC (adjusted HR = 2.23, 95% CI = 1.59-3.12) and CD (adjusted HR = 3.48, 95% CI = 2.42-4.99), respectively, than did the comparison cohort. UC and CD risks significantly increased in the appendectomy cohort regardless of whether appendicitis was present.

Conclusions: Our study suggests that appendectomy increases UC and CD risks irrespective of appendicitis.
Integrated Transcriptome and Proteome Analyses Reveal Protein Metabolism in Lactobacillus helveticus CICC22171
Authors: Xu Mengfan , Hu Shanhu , Wang Yiwen , Wang Tao , Dziugan Piotr , Zhang Bolin , Zhao Hongfei
Published: June 2021

Lactobacillus helveticus is a homofermentative lactic acid bacterium. It is widely used in the fabrication of Swiss cheese and other dairy products. The aim of this study was to elucidate the mechanism by which L. helveticus utilizes protein. Lactobacillus helveticus CICC22171 were cultured in two different media with various nitrogen sources. The control contained 20 basic amino acids, while the experimental medium contained casein. De novo transcriptome and isobaric tags for relative and absolute quantification (iTRAQ) proteome analyses were applied to determine how L. helveticus utilizes protein. The casein underwent extracellular hydrolysis via ATP-binding cassette (ABC) transporter upregulation and Mn2+-associated cell envelope proteinase (CEP) downregulation. Sigma factors and EF-Tu were upregulated and Mg2+ was reduced in bacteria to accommodate DNA transcription and protein translation in preparation for proteolysis. Hydrolase activity was upregulated to digest intracellular polypeptides and control endopeptidase genes. In these bacteria, casein utilization affected glycolysis, trehalose phosphotransferase system (PTS), and key factors associated with aerobic respiration and reduced glucose consumption.