bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements and Challenges in Addressing Zoonotic Viral Infections with Epidemic and Pandemic Threats
Authors: Fatima Munazza , An Timothy , Park Pil-Gu , Hong Kee-Jong
Published: February 2025

Zoonotic viruses have significant pandemic potential, as evidenced by the coronavirus pandemic, which underscores that zoonotic infections have historically caused numerous outbreaks and millions of deaths over centuries. Zoonotic viruses induce numerous types of illnesses in their natural hosts. These viruses are transmitted to humans via biological vectors, direct contact with infected animals or their bites, and aerosols. Zoonotic viruses continuously evolve and adapt to human hosts, resulting in devastating consequences. It is very important to understand pathogenesis pathways associated with zoonotic viral infections across various hosts and develop countermeasure strategies accordingly. In this review, we briefly discuss advancements in diagnostics and therapeutics for zoonotic viral infections. It provides insight into recent outbreaks, viral dynamics, licensed vaccines, as well as vaccine candidates progressing to clinical investigations. Despite advancements, challenges persist in combating zoonotic viruses due to immune evasion, unpredicted outbreaks, and the complexity of the immune responses. Most of these viruses lack effective treatments and vaccines, relying entirely on supportive care and preventive measures. Exposure to animal reservoirs, limited vaccine access, and insufficient coverage further pose challenges to preventive efforts. This review highlights the critical need for ongoing interdisciplinary research and collaboration to strengthen preparedness and response strategies against emerging infectious threats.
Development and Validation of a Differentiating Infected from Vaccinated Animals (DIVA) Enzyme-Linked Immunosorbent Assay (ELISA) Strategy for Distinguishing Between Hendra-Infected and Vaccinated Horses
Authors: McNabb Leanne , McMahon Amy , Woube Ezana Getachew , Agnihotri Kalpana , Colling Axel , Broder Christopher C. , Kucinskaite-Kodze Indre , Petraityte-Burneikiene Rasa , Bowden Timothy R. , Halpin Kim
Published: February 2025

Hendra virus (HeV) is a bat-borne zoonotic agent which can cause a severe and highly fatal disease and can be transferred from animals to humans. It has caused over 100 deaths in horses since it was discovered in 1994. Four out of seven infected humans have died. Since the release of the HeV vaccine (Equivac® HeV Hendra Virus Vaccine for Horses, Zoetis Australia Pty Ltd., Rhodes, NSW 2138) in Australia, there has been an urgent requirement for a serological test for differentiating infected from vaccinated animals (DIVA). All first-line diagnostic serological assays at the Australian Centre for Disease Preparedness (ACDP) incorporate recombinant HeV soluble G glycoprotein (sG) as the antigen, which is also the only immunogen present in the Equivac® HeV vaccine. Problems therefore arose in that antibody testing results were unable to distinguish between prior vaccination or infection with HeV. This study describes the development of a HeV DIVA ELISA strategy using recombinant sG and HeV nucleoprotein (N), paired with specific monoclonal antibodies in a competition ELISA format. The validation of this assay strategy was performed using a positive cohort of 19 serum samples representing post-infection sera, a negative cohort of 1138 serum samples representing horse sera collected pre-vaccine release and a vaccination cohort of 502 serum samples from horses previously vaccinated with Equivac® HeV vaccine. For the sG glycoprotein, the diagnostic sensitivity (DSe) was 100.0% (95% CI: 99.3–100.0%) and diagnostic specificity (DSp) 99.91% (95% CI: 99.5–100.0%), using a percentage inhibition cut-off value of >36, whereas for the N protein, DSe was 100.0% (95% CI: 82.4–100.0%) and DSp 100.0% (95% CI: 99.7–100.0%), using a percentage inhibition cut-off value of >49. Taken together, these results demonstrate that the HeV DIVA ELISA strategy developed here is now an essential and critical component of the testing algorithm for HeV serology testing in Australia.
Vaccination Coverage in Hematopoietic Stem Cell Transplant Patients
Authors: Bouzas-Rodríguez Angeles , Molina-Romera Germán , Vázquez-Lago Juan Manuel , Vázquez-Cancela Olalla , Fernández-Pérez Cristina
Published: February 2025

Background/Objectives: Patients undergoing hematopoietic stem cell transplantation (HSCT) experience profound immunosuppression, increasing their risk of infections. Revaccination is essential to reduce morbidity and mortality. This study aimed to evaluate post-transplant vaccination coverage among patients treated at a specialized reference center. Methods: We conducted a cross-sectional, retrospective study including patients who underwent HSCT between 1 January 2018 and 31 May 2021. Vaccination coverage was assessed for each recommended vaccine, and full compliance was defined according to the Spanish Ministry of Health guidelines. A competing risk survival analysis was performed to account for loss to follow-up due to death. Data analysis was carried out using STATA v15. Results: Among 138 included patients, 22.46% (31/138) died, and 11.59% (16/138) relapsed. Of the 107 patients who remained in follow-up at 19 months, 41.12% (44/107) (95% CI: 32.26–50.59) had completed the full vaccination schedule, while only 1.87% (2/107) (95% CI: 0.51–6.56) achieved temporal compliance. No significant association was observed between sex and vaccination status or competing risks (p > 0.05). Conclusions: Post-HSCT vaccination coverage remains suboptimal, highlighting the need for improved vaccination programs, multidisciplinary patient support, and enhanced public and professional awareness to ensure timely immunization in this high-risk population.
Safety Assessment of a Sublingual Vaccine Formulated with Poly(I:C) Adjuvant and Influenza HA Antigen in Mice and Macaque Monkeys: Comparison with Intranasal Vaccine
Authors: Yamamoto Tetsuro , Mitsunaga Fusako , Kotani Atsushi , Tajima Kazuki , Wasaki Kunihiko , Nakamura Shin
Published: February 2025

A sublingual vaccine comprising the Poly(I:C) adjuvant and influenza HA antigen was evaluated for safety in both mice and macaque monkeys relative to its intranasal counterpart. Safety was assessed in terms of harmful effects corresponding to the upregulation of the inflammation-associated genes Saa3, Tnf, IL6, IL1b, Ccl2, Timp1, C2, Ifi47, Aif1, Omp, Nos2, and/or Gzmb in mice and SAA2, TNF, IL6, IL1B, CCL2, TIMP, C2, AIF1, and GZMB in macaques. Quantitative gene expression analyses were performed using RT-qPCR with RNA samples from four tissue types, the olfactory bulb, pons, lung, tongue, and lymph node, from both mice and macaques. In mice, the intranasally delivered vaccine markedly upregulated the inflammation-related genes in the olfactory bulb 1 day and 7 days after vaccination. The adverse effects of intranasal vaccination were also observed in macaques, albeit to a lesser extent than in mice. The intranasal vaccination also upregulated these genes in the pons of both mice and macaques. In contrast, the sublingual vaccine did not adversely affect the olfactory bulb or pons in either mice or macaques. The intranasally administered vaccine significantly upregulated these genes in the lungs only 1 day after vaccination, but not 7 days later, in both mice and macaques. We conclude that intranasal vaccination results in unfavorable side effects corresponding to upregulated inflammatory genes in the brain (olfactory bulb and pons). Sublingual vaccination, however, did not induce these side effects in either mice or macaques and was hence evaluated as safe.
Hydrochemical Characteristics and Genetic Analysis of Groundwater in Zhanjiang City, Guangdong Province, South China
Authors: Wang Ying , Liu Zhenlin , Yang Junyi , Wang Junxia , Zhang Ling , Tan Yongqing , Xiang Dongjin
Published: February 2025

Groundwater serves as a vital water source in Zhanjiang City. This study analyzed the chemical components of 35 samples to understand the hydrochemical characteristics and evolution mechanism of groundwater in Zhanjiang City. A comprehensive analysis was conducted using statistical methods, including the use of Piper trilinear diagrams, the Gibbs method, ion ratios, and other techniques, to investigate the sources and control factors of the main ions in groundwater in the area. The findings reveal that all the groundwater is freshwater, with the main cations and anions being Na+ and HCO3−, respectively. Shallow water is mainly of the Cl•SO4 mixed cation type, followed by the HCO3•ClNa•Ca type. Middle and deep pore water is mainly of the HCO3Na type, followed by the HCO3Na•Mg type and HCO3Na•Ca type. The hydrochemical classifications of pore and fissure water are Cl•HCO3Mg•Na type and Cl•HCO3Na type water. The primary hydrogeochemical process is water–rock interaction, particularly the dissolution of silicate minerals. Additionally, evaporation and concentration contribute significantly to the chemical composition of shallow water, and ion exchange is also an important hydrogeochemical process affecting middle and deep pore water. Shallow water commonly contains nitrates, with 37.5% of shallow water showing contamination with NO3−. This study aims to provide insights into the development and utilization of local water resources.
Effect of Salt Solution on Water-Retention and Microstructure Characteristics of Ningming Expansive Soil
Authors: Yu Mingbo , Zhou Chunyuan , Han Xiao , Niu Geng
Published: February 2025

The pore solution in expansive soil contains numerous chemical components that can significantly affect the soil’s water-retention properties, strength, and deformation. This study focuses on Ningming expansive soil and investigates the effects of varying concentrations of NaCl solutions on its water-retention characteristics. The soil–water characteristic curve of expansive soil over the full suction range was obtained using the pressure plate method. The microstructure of expansive soil was analyzed using mercury intrusion porosimetry and scanning electron microscopy. The results indicate that the water-retention capacity of expansive soil increases with higher concentrations of NaCl at equivalent suction levels. MIP tests demonstrated that, regardless of changes in pore solution concentration, the interparticle pores in pre-consolidated samples consistently dominate the pore structure, while agglomeration pores play a secondary role. Importantly, variations in the pore solution concentration primarily alter the characteristics of interparticle pores without significantly affecting their overall structure. SEM analysis revealed that the microstructure of pre-consolidated samples exposed to different pore solution concentrations exhibited less development than that of compactable samples, with a notable reduction in macropores. Furthermore, the arrangement of soil particles became increasingly uniform, and the stratification within the soil matrix was more pronounced. In addition, the Brooks–Corey (BC) model and van Genuchten (VG) model were employed to fit the measured data. It was found that the air entry values predicted by the two models were closely aligned with the measured data; therefore, it is recommended to utilize the average value as the air entry value corresponding to the changes in pore solution concentration of pre-consolidated Ningming expansive soil.
A Dynamic Flowmeter-Monitoring Path-Partitioning Strategy for Real-Time Demand Estimation in Water Distribution Systems
Authors: Li Xiujuan , Zhou Yisu , Hu Chenxi , Zhang Yong , Wang Jiangxia , Liu Jingqing
Published: February 2025

The hydraulic model serves as an effective tool for operational simulation, dispatch decision-making, and engineering planning in water distribution systems (WDSs). The increasing complexity of large-scale networks and the growing number of monitoring devices present both challenges and opportunities for the online calibration of WDSs in terms of efficiency and accuracy. To address these issues, this paper introduces a novel strategy, Flowmeter-Monitoring Path-Partitioning (FMPP), for nodal demand calibration of hydraulic models. FMPP partitions nodes based on the monitoring paths of flowmeters, which include all downstream nodes of a given flowmeter. Then, a system of equations is formulated from the mass and energy conservation, and an iterative optimization process is employed to calibrate the nodal demands. This method enables the partitioning of nodes to achieve the optimal granularity, enabling each flowmeter to be calibrated individually and also reducing the calibration parameters through node grouping. The performance of the proposed method has been validated through two comprehensive case studies, demonstrating its superiority to conventional calibration techniques in terms of accuracy, computational efficiency, and practical applicability in real-time nodal demand estimation. This approach meets the requirements for the real-time calibration of nodal demand in complex large-scale pipe networks.
Technical, Economic, Energetic, and Environmental Evaluation of Pretreatment Strategies for Scaling Control in Brackish Water Desalination Brine Treatment
Authors: Lugo Abdiel , Mejía-Saucedo Carolina , Senanayake Punhasa S. , Stoll Zachary , Sitterley Kurban , Wang Huiyao , Kota Krishna , Kuravi Sarada , Fthenakis Vasilis , Kurup Parthiv , Xu Pei
Published: February 2025

Effective pretreatment is essential for achieving long-term stable operation and high water recovery during the desalination of alternative waters. This study developed a process modeling approach for technical, economic, energetic, and environmental assessments of pretreatment technologies to identify the impacts of each technology treating brackish water desalination brine with high scaling propensity. The model simulations evaluated individual pretreatment technologies, including chemical softening (CS), chemical coagulation (CC), electrocoagulation (EC), and ion exchange (IX). In addition, combinations of these pretreatment technologies aiming at the effective reduction of key scaling constituents such as hardness and silica were investigated. The three evaluation parameters in this assessment consist of levelized cost of water (LCOW, $/m3), specific energy consumption and cumulative energy demand (SEC|CED, kWh/m3), and carbon dioxide emissions (CO2, kg CO2-eq/m3). The case study evaluated in this work was the desalination brine from the Kay Bailey Hutchison Desalination Plant (KBHDP) with a total dissolved solids (TDS) concentration of 11,000 mg/L and rich in hardness and silica. The evaluation of individual pretreatment units from the highest to lowest LCOW, SEC|CED, and CO2 emissions in the KBHDP brine was IX > CS > EC > CC, CS > IX > EC > CC, and CC > CS > EC > IX, respectively. In the case of pretreatment combinations for the KBHDP, the EC + IX treatment combination was shown to be the best in terms of the LCOW and CO2 emissions. The modeling and evaluation of these pretreatment units provide valuable guidance on the selection of cost-effective, energy-efficient, and environmentally sustainable pretreatment technologies tailored to desalination brine applications for minimal- or zero-liquid discharge.
PROTOKOL PERESEPAN LATIHAN FISIK UNTUK PEMULIHAN KEKUATAN OTOT PASIEN GUILLAIN-BARRE SYNDROME: TELAAH LITERATUR
Authors: Permana Gilang Pradipta , Laily Inarota
Published: February 2025

Pasien Guillain-Barre Syndrome (GBS) fase pemulihan sering mengalami kelemahan otot yang berkepanjangan, yang dapat menurunkan kualitas hidup. Latihan fisik membantu meningkatkan kekuatan otot, tetapi belum ada rekomendasi protokol untuk latihan fisik pada pasien GBS. Studi ini membahas frekuensi, intensitas, jenis, dan durasi latihan fisik untuk meningkatkan kekuatan otot pasien GBS. Penelusuran sistematis dilakukan pada Pubmed, Cochrane, Embase serta hand-searching di Google Scholar menggunakan kata kunci “GBS”, “latihan fisik”, dan “kekuatan otot”. Kriteria inklusi adalah terbit tahun 2013-2023, full-text berbahasa Indonesia atau Inggris, subjek pasien GBS yang diintervensi latihan fisik, luaran kekuatan otot dengan desain: controlled trial, case control, case series, dan laporan kasus. Dari pencarian sistematis,  terpilih 1 studi dari 18 studi, sedangkan dari metode hand-searching didapatkan 6 artikel, sehingga total 7 studi terpilih. Latihan berjenis kekuatan otot dapat meningkatkan kekuatan otot pasien GBS dan perlu ditunjang oleh latihan kardiorespirasi, latihan berjalan, dan latihan keseimbangan untuk mendukung pemulihan pasien GBS. Frekuensi latihan berkisar antara 2-5 kali per minggu, sementara intensitas latihan bervariasi yang disesuaikan dengan kemampuan pasien. Durasi latihan 20-60 menit, dengan lama intervensi 6 minggu-1 tahun. Hasil didapatkan dari studi-studi terbaru. Namun, kurangnya kelompok kontrol serta ukuran sampel yang relatif kecil (4-30 subjek) menjadi keterbatasan. Terdapat faktor perancu kekuatan otot yang meningkat akibat reinervasi alami. Pasien GBS sebaiknya melakukan jenis latihan kekuatan otot, kardiorespirasi, dan latihan fungsional, dengan frekuensi 2-5 kali per minggu, intensitas ringan-sedang yang dinaikkan secara bertahap, 20-60 menit per sesi dengan lama intervensi 6-12 minggu.
BIOENERGY ASSETS IN THE STRATEGY FOR ACHIEVING CLIMATE NEUTRALITY: CLASSIFICATION FOR ACCOUNTING PURPOSES
Authors:   Chernivtsi Institute of Trade and Economic of SUTE, Yuliіa Bila
Published: February 2025

The global climate and energy crises pose new challenges to humanity that
require urgent solutions. The use of renewable energy sources, particularly
bioenergy, is one of the ways to address these large-scale problems. The task of
accounting is to provide enterprise managers with a high-quality information base on
bioenergy assets to enable effective management of these assets.
The aim of the study is to develop a classification of bioenergy assets for their
reflection in the enterprise's accounting information system.
The article uses general scientific and specialized analytical methods to study
economic phenomena: the deduction method is used at the stage of collecting and
processing information on the technological process of biofuel production; the system
analysis is used to study the main approaches to asset classification in enterprises;
the induction and generalization methods are applied in the process of forming
classification criteria for bioenergy assets for accounting purposes.
The article examines the technology of biofuel production from energy crops and
biomass, which has allowed the classification of bioenergy assets according to their
participation in the economic process. The main classification criteria of bioenergy assets
for accounting purposes are determined. It is proposed to use the developed classification
as a theoretical basis for the formation of the accounting methodology for bioenergy
assets. The research carried out and the recommendations provided are of practical value
for enterprises carrying out the accounting for bioenergy assets.
Further research is needed to develop a methodology for accounting for
bioenergy assets that will provide information on strategic bioenergy objects.
CONSUMER BEHAVIOR OF RECREATION AND HOSPITALITY SERVICES AS A CONDITION FOR REGIONAL TOURISM DEVELOPMENT IN CRISIS PERIODS
Authors:   Chernivtsi Institute of Trade and Economic of SUTE, Roman Hyshchuk
Published: February 2025

Hospitality and recreational services in a broad and general sense form the basis
of tourism. Their quality influences consumer behavior, service levels and, in general,
the overall development of the products concerned. Hospitality services undoubtedly
have a positive impact on the economy of many countries and regions. However,
domestic tourism and recreation in Ukraine is still experiencing difficult times due to
the continuing martial law and the effects of the COVID-19 pandemic. A significant
number of hotels and other hospitality-related businesses are currently experiencing
significant problems in their further development. These risks are creating difficulties
for people who work in the tourism sector or interact with it as contractors. Our task
is to assess the current regional features of tourism development and determine their
impact on the management of the behavior of consumers of recreational and
hospitality services in Ukraine and its regions in the conditions of pandemic, war and
social crisis periods. In the process of conducting the research, literary analysis,
synthesis, induction, deduction, analogy were used; specifically scientific: factor
analysis and statistical methods.
The article examines the global and domestic development of hospitality
services during the period of the COVID-19 pandemic and martial law, with the main
trends of the impact of tourism and socio-cultural demands of society on them. The
results of the scientific research can be used by state and local self-government
bodies to develop and substantiate prospective strategic plans for the organization,
management and development of the Carpathian territories in the context of
managing the behavior of consumers of recreational and hospitality services as a
condition for the regional development of tourism in crisis periods. Theoretical-
methodological and applied developments, together with the obtained results, can be
used in similar studies to form a perspective strategy for cross-border cooperation of
the Carpathian regions in overcoming the current crisis phenomena in hospitality
services caused by the COVID-19 pandemic and martial law.
Démarche diagnostique des intoxications non aiguës des colonies d’abeilles : possibilités et limites pour le clinicien
Authors: Grisot Lionel
Published: February 2025

Les intoxications subaiguës et chroniques demeurent méconnues. Au regard de la pluralité des co-expositions et facteurs de stress susceptibles d’affaiblir les abeilles et leurs colonies, elles sont particulièrement complexes à identifier. Leur expression clinique peut être variable d’un rucher à l’autre, voire d’une colonie à l’autre. Au cœur de cet exposome multifactoriel et, faute de signes cliniques pathognomoniques, la complexité des troubles induits par les intoxications subaiguës ou chroniques conduit le clinicien à recourir à des analyses toxicologiques, dont l’interprétation peut s’avérer difficile. En considérant la temporalité des événements, le clinicien cherchera à objectiver les causes déterminantes ou prépondérantes dans la rupture de l’équilibre vital du super-organisme qu’est la colonie et dans la survenue des différents signes cliniques. Les nombreuses incertitudes rencontrées au cours des investigations pourraient conduire à des erreurs de diagnostic, par défaut comme par excès, que le clinicien s’efforcera d’éviter ou, à tout le moins, qui le conduiront à relativiser ses conclusions.
Enhancing understanding of physiology through literature reinterpretations: insights from 'physioart: once upon a time...
Authors: Cruz Josiane Campos , Coitinho Larissa Maria
Published: February 2025

The interdisciplinary nature of physiology challenges students, making it difficult for them to grasp its concepts. Therefore, developing active pedagogical approaches is essential for more effective teaching and learning. With this objective in mind, we created the "PhysioArt: Once Upon a Time..." project, which integrates physiology and literature to spark students' interest and facilitate the assimilation of physiological concepts. The activity involves reinterpreting passages from classic literary short stories, incorporating physiological concepts in a contextualized manner. As part of the experience, students reinterpreted short stories by Edgar Allan Poe within the context of the respiratory system and works by Brazilian writer Machado de Assis within the context of the endocrine system. Following this, 62 students voluntarily participated in an evaluation questionnaire about the activity. The results show that 86% of students find physiology challenging. However, 79% stated that reinterpreting the short stories motivated them and helped them better understand physiological concepts. Additionally, 89% reported that "PhysioArt: Once Upon a Time..." increased their interest in learning physiology more engagingly and enjoyably. Notably, 58.4% of participants highlighted that this interdisciplinary activity helped reduce academic stress by incorporating art through literature helped reduce academic stress. These findings suggest that "PhysioArt: Once Upon a Time..." is an active teaching methodology that promotes learning in a dynamic, participatory, and enjoyable way. It encourages student engagement and enhances their understanding of physiological concepts.
The impacts of AI and automation on human resource management – systematic review
Authors: Santos Fernanda Maria de Almeida , Pereira Aida , Shanches Alexandre , Crespo Diogo , Pala Henriqueta
Published: February 2025

This study focuses on the growing impact of Artificial Intelligence (AI) and automation on the Human Resource Management (HRM) processes of organizations. It examines how these emerging technologies are redefining HRM practices, with a particular focus on recruitment, training and human capital management. A methodology was used that integrates a quantitative analysis, derived from data collected through a structured survey on a Likert scale, and a systematic review of the literature. This two-pronged approach allowed us to assess perceptions about the implementation of AI in HRM and to identify emerging trends and patterns in recent studies. The results show that AI and automation contribute to greater efficiency in recruitment and selection processes, promoting greater equality in the identification and progression of talent. There was also a positive impact on skills development and vocational training, underlining the importance of adaptive strategies for the continuous development of employees. We face ethical and privacy challenges regarding the use of AI in HR. It highlights the need for robust practices for the protection of employee data and the prevention of bias and discrimination in algorithms. The importance of human intervention in automated decisions is highlighted, ensuring the maintenance of fairness and ethics, as well as the need for professional requalification in the face of technological changes. The study concludes that despite the challenges, AI and automation offer unprecedented opportunities for innovation in HRM. Organizations that integrate these technologies with the human elements of work are better prepared for a dynamic and technologically advanced future.
A influência da higiene oral na prevenção da pneumonia associada à ventilação em pacientes internados em Unidades de Terapia Intensiva: uma revisão integrativa
Authors: Rodrigues Ana Thallyta da Siva , Morais Vitória Alexandre de , Nascimento João Victor Menezes do , Lemos Marcelo Victor Sidou , Feitosa Alinne Patierry Oliveira Pacifico , Pereira Carla Kuroki Kawamoto , Gurgel Filho Eduardo Diogo , Pereira Sérgio Luis da Silva
Published: February 2025

A falta de cuidados com a higiene oral pode implicar na saúde sistêmica do indivíduo, aumentando seu tempo de internação e elevando os custos para a saúde. Considerando-se o aumento do número de casos de pneumonia nosocomial, é necessário o cuidado oral e integral do paciente hospitalizado. Pacientes em unidades de terapia intensiva (UTIs) que fazem uso de ventilação mecânica, podem ter a região da traqueia e orofaringe comprometida pela comunicação com a cavidade oral. Objetiva-se então analisar o impacto da higienização oral realizada nos pacientes hospitalizados na redução do risco de desenvolvimento da PAV. A busca dos artigos foi realizada nas bases de dados PubMed, cruzando os seguintes descritores disponíveis no Decs: “higiene oral”, “doença periodontal” e “pneumonia nosocomial” e os termos correspondentes em inglês: “oral hygiene”, “periodontal disease” e “nosocomial pneumonia”. Os resultados revelaram que a higienização realizada de forma adequada causa impacto positivo na prevenção e diminuição da incidência de PAV em pacientes em unidades de terapia intensiva, e que o diguclonato de clorexidina desempenha a função antibactericida e bacteriostática, agindo sobre as bactérias da infecção aguda que afetam o trato respiratório inferior. Conclui-se que novos estudos devem ser desenvolvidos para se determinar quais as técnicas de higienização devem ser mais indicadas e quais os materiais ou substâncias serão aplicados em relação às suas dosagens e frequência para que a prevenção e diminuição da incidência de Pneumonia ocorra a partir dos protocolos realizados.
Tratamento da hipersensibilidade dentinária proviniente de lesões cervicais não cariosas por meio físico e químico: estudo de boca dividida
Authors: Silva Hitalo Klainer da Nóbrega , Lima Larianne Priscila Rocha de , Siqueira Virginia Rodrigues de Oliveira , Coutinho Katharine Lucena , Souto Fernanda Ferreira , Costa Taciane Cavalcanti Silva da , Durão Márcia de Almeida
Published: February 2025

Introdução: As lesões cervicais não cariosas (LCNCs) são caracterizadas pela perda de tecido dentinário na regiãoda amelo-cementária. Os primeiros impactos na saúde bucal dessas lesões podem aparecer na região esmalte-dentina, como é o caso da hipersensibilidade dentinária cervical (HDC), e no nível radicular, como a recessão gengival (RG). A HDC tem sido descrita na literatura como uma resposta rápida à dor, causada por ar, frio, toque, estímulos ácidos ou uma combinação desses estímulos. Objetivo: observar e comparar a efetividade clínica de dois protocolos dessensibilizantes. Métodos: Trata-se de um relato de caso clínico realizado na Clínica Escola de Odontologia da Uninassau – Recife para o tratamento da hipersensibilidade dentinária cervical (HDC) em boca dividida, com o uso de laserterapia e gel dessensibilizante de ação neural. Resultados: a paciente selecionada procurou atendimento tendo como queixa principal a sensibilidade dentinária. Após anamnese e exame físico, constatou-se a necessidade de tratamento para hipersensibilidade em dentes posteriores com LCNC, atendendo aos critérios de inclusão deste estudo. Conclusão: Portanto, ao final do estudo, os dois protocolos cumpriram com os objetivos ao chegar no parâmetro de dor leve, entretanto, o gel dessensibilizante atingiu o nível 0 na escala de dor, sendo assim, mais efetivo que o protocolo físico. Ao término das sessões, visando um controle da tensão oclusal foi confeccionada a placa oclusal.
Microcirurgia plástica e reconstrução mamária: impacto estético e psicológico nas pacientes com câncer de mama
Authors: Roriz Everton Coimbra , Santos Luísa Dunguel Pereira dos , Dechichi Fernando Lacerda Zafred , Barbosa Davi Carvalho , Barrueco ⁠Amanda Raissa Carvalho Santos , Garcia Eduardo dos Santos , Bispo Cristiane Pereira , Sousa Arllington Campos , Santos Isabella Ribeiro dos , Silva Maria Clara Ferreira da , Dias Loide Gomides Oliveira , Ramos Ana Carla de Oliveira , Moreira Fernanda , Campos Dominique Paiva Prudente , Silva Andrew Camargos , Oliveira Alisson Rodrigues de , Silva Neto Genival José da , Queiroz Sarah Kelly Bueno de
Published: February 2025

A microcirurgia plástica para reconstrução mamária com retalhos autólogos, especialmente após mastectomia por câncer de mama, oferece resultados estéticos e psicológicos significativos. Este estudo analisou técnicas como o retalho TRAM e DIEP, demonstrando alta taxa de sucesso, menor risco de complicações e impacto positivo na autoestima das pacientes. Foram incluídos estudos que avaliaram o impacto físico e emocional dessas técnicas, comparando reconstrução imediata e tardia. Os resultados evidenciam que a reconstrução imediata favorece uma recuperação psicossocial mais rápida, com maior satisfação estética. A integração de suporte psicológico e o alinhamento pré-operatório de expectativas são essenciais para a recuperação completa das pacientes.
Diagnóstico clínico e histopatológico do Líquen Plano Oral (LPO): relato de caso
Authors: Brito Palloma Santana , Lucena Luanna Lima , Vieira Rafaelly Alves , Acioly Gabrielly Maria Argoro , Zaidan Nathália Régia Tenório , Santos Siderval Moura , França Glória Maria de , Oliveira Catarina Rodrigues Rosa de
Published: February 2025

O líquen plano (LP) é uma doença inflamatória mucocutânea crônica, com etiopatogenia desconhecida. Que afeta principalmente a pele e a mucosa oral, com maior incidência no sexo feminino de meia-idade. Este relato de caso tem como objetivo destacar um caso de Líquen Plano Oral (LPO) em um paciente do sexo feminino com 34 anos de idade, que procurou diagnóstico diante da queixa de “uma lesão em língua”. Ao exame clínico extra oral, evidenciou-se a presença de mancha única, de coloração marrom, localizada no lábio inferior. Ao exame intraoral, foram observadas placas brancas à direita em mucosa jugal e no dorso da língua. A hipótese diagnóstica foi de LPO, posteriormente confirmado com o diagnóstico histopatológico. Após 15 dias com tratamento utilizando corticoide tópico, observou-se melhora significativa. A paciente está em acompanhamento, apresentando remissão das lesões há cerca de três meses.
Terapêuticas possíveis para doença arterial obstrutiva periférica: uma revisão de literatura
Authors: Luize Léo Morato , Neves Maria Clara Monari , Silva Gabriela Teixeira da , Ramirez Ana Luísa Garcia , Menezes Pedro Otávio Assis , Medeiros Lavínia Barros , Pastrelo Eloisa Stefanin , Peres Lucas Berti , Reis Beatriz Bottoni dos , Assad João Pedro , Oliveira Carolina Kfouri de , Silva Maria Montenegro de Souza e , Cella Pedro Michelão , Nakano Isabella Cristine Febraio , Brauns Giovanna Tolentino , Queiroz Maria Fernanda Chaves , Ferraz Giulia de Bortoli , Brauns Giulia Tolentino
Published: February 2025

A doença de origem aterosclerótica causadora da obstrução das extremidades, conhecida como doença arterial obstrutiva periférica (DAOP), atinge até 50% dos idosos com 85 anos ou mais. o principal sintoma associado à  DAOP é a claudicação, ou seja, sensação de fadiga e dor muscular, principalmente no músculo da panturrilha, induzida por exercício e com melhora ao descanso (Firnhaber, 2019). A isquemia crítica é o quadro mais grave relacionado a DAOP, sendo caracterizado pelo comprometimento vascular avançado, com claudicação mesmo no repouso, úlceras e gangrenas, todos atribuídos à oclusão arterial importante. Dentre as formas de tratamento tanto da DAOP, quanto da isquemia crítica, tem-se o controle de fatores predisponentes de aterosclerose e obstrução arterial, medicações para controle da claudicação e a revascularização endovascular ou cirúrgica, sendo este último o tratamento mais efetivo na atualidade (Elsayed, 2015). O objetivo deste estudo é avaliar o tratamento e manejo da DAOP, buscando aprimorar a compreensão acerca das possibilidades na atualidade, com enfoque na terapia de revascularização. Para isso, foi realizada uma revisão integrativa de literatura, a partir da base de dados PUBMED, utilizando descritores e critérios de inclusão e exclusão para selecionar os artigos utilizados para o embasamento deste trabalho. Os resultados demonstraram que os tratamentos mais utilizados e aceitos são as mudanças de estilo de vida e tratamento medicamentoso para controle dos fatores componentes da DAOP, uma vez que são utilizados em todos os pacientes, desde os assintomáticos até os pacientes graves. Além disso, as controvérsias a respeito da abordagem cirúrgica de revascularização ou endovascular ainda permanecem no meio científico. Por um lado encontra-se uma técnica mais antiga e mais estudada, porém com riscos inerentes de terapias invasivas, as cirurgias, enquanto do outro lado encontra-se uma terapia mais segura aparentemente, porém com menos tempo de aplicação e menos estudos com metodologias aplicáveis para elaboração de diretrizes de uso, a endovascular. Assim, é possível concluir que, no que tange ao tratamento da doença arterial obstrutiva periférica, existe maior consenso em terapias menos invasivas, mas para terapias mais invasivas, as quais são indicadas quando as demais saõ insuficientes para tentar manter o fluxo sanguíneo, ainda não há consenso exato considerando os perfis de segurança e prós e contras de cada uma.
Determinants in Selecting Cement Brands
Authors: Anitha T , Maliqjan N , Gopi R
Published: February 2025

Customers’ preferences for cement brands are influenced by various factors including price, quality, brand image, durability, and availability. However, the relative importance of these factors and their impact on customers’ purchasing decisions are not well-documented. The present study aims to identify the highly preferred cement brand in the study area and to reveal the factors influencing their preference. One hundred fifty respondents were selected to express their opinion by adopting convenience sampling technique it is non probability sampling. The data was analyzed using Simple percentage and Friedman Rank Test. Ramco is identified as highly preferred cement brand in Tiruppur district. Price was the most prioritized factor while Packing was the least factor influencing the preference for cement brands. By maintaining competitive pricing and the value proposition effectively, the companies can strengthen its market and sustain customer loyalty.
From Hurdles to Renewed Growth: A Meta-Analysis of Green HRM’s Trajectory towards Sustainability
Authors: Gupta Vishakha , Kumari Santosh
Published: February 2025

Purpose: The study examines recent definitions and theoretical frameworks of Green Human Resource Management (GHRM) and investigates how GHRM is linked to the literature on sustainability. The outcomes of the study have consequences that influence the way GHRM is measured and the future studies in this field are relatively under explored where Human Resource Management (HRM) intersects with Environmental concerns or Sustainability. Design / Methodology / Approach: The study uses meta-review of Green HRM literature which reveals that it is an established burgeoning field of study built on practical research over the previous five years. Findings: The analysis finds literature evidence for supporting the impact of HR activities connected to the greening of ongoing competency development and the enhancement of social outcomes particular to the organization. Furthermore, the research findings indicate that distinct viewpoints employed in the conceptualization of GHRM disclose the varying effects of Green practices on environmental and organizational sustainability. These findings underpin the increasing acknowledgement of GHRM as a crucial instrument for entities to exhibit their dedication to being conscientious stakeholders in the socioeconomic system. Originality/value: The review would be valuable to GHRM scholars as it offers an in-depth elucidation of how GHRM issues are delineated and assessed. Prior reviews have identified a gap in research related to comprehending the conceptualization process, and therefore, one of the primary aims of this paper is to contribute to the advancement of knowledge by shedding light on the historical progression of research in this area.
Industrial Development and Global Competitiveness via Artificial Intelligence
Authors: Nithya J. , Sarojini S. , Tilaka S. , Varshini R.
Published: February 2025

In today’s era of Industrialization and advancement in technology, the artificial intelligence has started reshaping industries worldwide, industries are boosted up with efficiency, more space for innovation, which eventually enhances competitiveness among them. This paper examines role of AI in global industrial growth, its influence on competitive edge and its anticipated future trends. AI has come up with applications like extrapolative maintenance, smart manufacturing tools and techniques, supply chain optimization methods, and to its peak it has started with innovation hubs. With these massive upgradations the industries are becoming ever more efficient and resilient. This study also highlights the potential of AI to support personalized production, robust changes in sustainability efforts, and foster cross-border trade and collaboration.
Innovative Strategies of Plant-Based Therapies in Diabetic Wound Healing: Mechanisms and Advances
Authors: Raghavi S. , Haritha S. , Basha Jahankir Mohamed Jameer
Published: February 2025

Wound healing is a critical global health issue, significantly affecting patient outcomes and healthcare systems, particularly in developing countries with limited resources. Chronic wounds, especially diabetic ulcers, pose a serious challenge due to their prolonged healing time and high risk of complications. Herbal medicine is increasingly sought as an alternative or complementary treatment, driven by its affordability, accessibility, and minimal side effects. Medicinal plants are known to possess bioactive compounds that can enhance wound healing by targeting multiple biological pathways. Diabetes, a condition affecting over 530 million people in 2024, disrupts the natural wound-healing process through persistent hyperglycemia, which leads to poor circulation, impaired immune function, and elevated oxidative stress. Projections suggest that by 2050, the number of diabetic individuals will rise to 783 million, highlighting the urgent need for innovative and effective solutions to manage diabetic wounds. This paper will explore the factors affecting wound healing in diabetic patients, including glycemic control, vascular complications, and infection risks. It will also examine the mechanisms of action of medicinal plants, focusing on their role in promoting angiogenesis, reducing inflammation, and enhancing collagen synthesis. By discussing these aspects, this review aims to provide insights into the potential of medicinal plants as viable options for improving wound healing outcomes in diabetic patients.
A Rereading of Manimekalai
Authors: Murugesapandian N
Published: February 2025

Shathanar’s Buddhist propaganda purpose is embodied in Manimekalai epic’s excessive natural events and supernatural legends. The effort of religions to suppress the human senses that wash the human body has been emphasized in the Buddhist tradition. In the face of increasing inequality among people, Manimekali narrative has tried to subtly do the work of justifying existence. The emphasis on morals and ethics on religious grounds shows that the power of the rulers of the day was strengthened. The Manimekala epic was created to justify all kinds of oppression when Buddhism merged with state power.
Candidaturas a alcaldías y vicealcaldías de personas menores de edad
Authors: Luis Diego Brenes Villalobos
Published: February 2025

El presente ensayo expone la tesis de minoría de la sentencia del Tribunal Supremo de Elecciones n.° 9352-E3-2023 del 17 de noviembre de 2023 en la que se defiende una forma diferenciada acerca de cómo deben acreditarse los dos años de inscripción electoral ininterrumpida para servir el cargo de alcaldía o vicealcaldía a una persona menor de edad entre sus 16 y 18 años. Se defiende que no resulta jurídicamente posible, por inconvencional e inconstitucional, que el juez electoral interprete la existencia de requisitos adicionales para ocupar esos cargos, más allá de los que exige la literalidad de la ley.
Pachacamac: hito de navegación a fines del s. XVIII y principios del siglo XIX
Authors: Pozzi Escot Denise , Salas i Vila Nuria , Villar Rocío , Fuertes Sarita
Published: February 2025

En el santuario de Pachacamac residía una de las principales deidades del Perú prehispánico; su poder se expresaba en la convocatoria a decenas de peregrinos que llegaron a este espacio sagrado a gestionar sus súplicas. Su emplazamiento estratégico se reafirmó en el último periodo de ocupación prehispánica, cuando con la llegada de los Incas y la construcción del Templo el Sol, además de sus esenciales funciones religiosas, este edificio transformó el paisaje litoral marino con fines económicos y políticos. En el imaginario de los s. XX y XXI, Pachacamac representa un conjunto de construcciones sacralizadas en el desierto costero. Con la intención de comprender las relaciones que existieron entre el santuario y su territorio circundante, analizamos el registro arqueológico, representaciones prehispánicas en diversos soportes, crónicas coloniales, cartas náuticas de los s. XVIII y XIX y referencias de científicos-viajeros del s. XIX, que nos sugieren que el significado de Pachacamac no radicó únicamente en los edificios y templos construidos por las sociedades prehispánicas a lo largo de mil años, sino que el santuario se extendió en un espacio continuo, que involucró, desde sus primeros tiempos, ecosistemas acuáticos, humedales costeros, el río Lurín y su valle, la línea litoral y las islas adyacentes, como elementos y símbolos de su prestigio y sacralidad como expresión de nuestra identidad cultural andina.
Estudio de balas y botones recuperados del actual lago artificial San Roque (valle de Punilla, Córdoba, Argentina)
Authors: Mendoza Alejandro Adrián
Published: February 2025

En este trabajo se analiza un conjunto de balas esféricas y botones identificados cronológicamente como correspondientes al siglo XIX. Los mismos fueron rescatados del actual lago San Roque (valle de Punilla) y forman parte del reservorio de la Reserva y Laboratorio Achala Sacate, Museo NumbaCharava, del Museo Municipal y Archivo Histórico, La Memoria de Icho Cruz y de colecciones particulares. Se analiza el tipo de contexto, los espacios donde se encontraban distribuidos, su asociación con otros materiales de ese período, medidas y peso. También se describe si las balas presentan marcas de impacto, el tipo de calibre y las probables armas utilizadas. El objetivo en esta primera etapa de investigación es intentar establecer, si existe una vinculación o no con la batalla de San Roque (1829). Los resultados muestran que la mayor cantidad de balas esféricas, presentan un calibre con valores cercanos a los 13 mm de diámetro, y pueden corresponder por su tamaño inferior a 16 mm, a balas de tarros de metralla, aunque no se descarta una segunda probabilidad de que pertenezcan a armas de avancarga recortadas, tercerolas o pistolas o ambas posibilidades. Tampoco se descarta que hayan sido utilizadas en maniobras militares, campamentos u otra actividad posterior a la batalla. En el caso de los botones asociados a este tipo de balas, principalmente aquellos que se hallaron en mayor cantidad, cuyas características corresponden a botones semiplanos, lisos, de tres y cuatro orificios, de tonalidad gris. Su cronología es variada, ya que se observa su uso en gran parte del siglo XIX y es difícil determinar con precisión si corresponden a la batalla de San Roque o a un momento posterior.
Analysis of User Satisfaction on the Shopeepay Application by Using the Usability Method
Authors: Fitriasari Fatinah  , M. Rudi Sanjaya
Published: February 2025

This study aims to analyse the level of user satisfaction with the ShopeePay digital wallet application using the Usability method. This method has five variables to evaluate the level of user satisfaction, namely Learnability, Efficiency, Memorability, Errors, and Satisfaction. Data was collected through a questionnaire of 262 data with case study specifications on Sriwijaya University students. The reason for the research is because of the population and diversity of Sriwijaya University students from various faculties and regions who study at Sriwijaya University. The results of the analysis show that the usability method applied contributes significantly to user satisfaction. The variables that have been set show positive and negative influences from users. The Shopee Pay application analysed aims to measure the level of user satisfaction, by understanding the factors that influence customer satisfaction to maintain the quality of the ShopeePay digital wallet (e-wallet) service.