bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of information service in rational pharmacotherapy with thioctic acid in patients in Preferential Medicinal Providing
Authors: Eliseeva E. V. , Maneeva E. S. , Gribova V. V. , Okun D. B. , Savitskaya D. V.
Published: April 2021

Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals. Thioctic (Alpha-lipoic) Acid preparations are widely used in the preferential segment, their appointment is not always advisable due to the frequent use «off-label», which leads to ineffective treatment and unreasonable economic costs.Aim.Conduct an information search and filling the electronic service «Database of Clinical Trials of Medicines» for medicinal products containing Thioctic (Alpha-lipoic) Acid and provide author’s recommendations for rational pharmacotherapy.Materials and methods.The search and analysis of the results of clinical trials, systematic reviews and meta-analysis in international and Russian Databases — PubMed, EMBASE, Cochrane Collaboration, e-Library, «Cyberlininka» for medicines of metabolic action — Thioctic (Alpha-lipoic) Acid with their subsequent introduction into the Information Service «Database of Clinical Trials of Medicines».Results.Thioctic (Alpha-lipoic) Acid has a positive effect in the form of improvement of the clinical condition of patients and indicators of neurological scales in diabetic and alcoholic polyneuropathy without affecting the «hard» endpoints (decrease in the number of fatal complications and mortality).Conclusion.Service «Database of Clinical Trials of Medicines» for use by health care professionals and the author’s recommendations for the use of Thioctic (Alpha-lipoic) Acid can be used for the rational prescription of this medicines in Preferential Medicinal Providing.
Penerapan Algoritma Sweep Dalam Perencanaan Pendistribusian Produk Roti di Wilayah Kota Yogyakarta
Authors: Nugroho Yohanes Anton , Yatmoko Rolis Andika
Published: April 2021

Tujuan dari penelitian ini adalah untuk membuat solusi baru untuk distribusi produk Sari Roti di CV Jogja Transport. CV Jogja Transport mengantarkan produk roti baru dan mengambil produk-produk yang tidak terjual akan diganti dengan produk-produk baru. CV Jogja Transport memiliki empat karyawan yang melayani sebagai distribusi produk Sari Roti di kota Yogyakarta. Mereka memiliki sistem kerja bergulir dengan jam kerja mulai pukul 06.00 WIB hingga 12.00 WIB. Terbatasnya kapasitas kendaraan dan waktu pengiriman yang disarankan menyebabkan pengiriman tidak sesuai dengan rencana. Dalam tulisan ini, kami menunjukkan aplikasi dari Algoritma Sapu untuk menghasilkan rute distribusi baru. Pertimbangkan aturan distribusi dan sumber daya; Algoritma Sapu mencoba membawa cluster distribusi baru dan tugas penjualan. Solusi ini mengurangi jarak dari gudang CV Jogja Transport ke setiap lokasi toko yang 115,39 Km menjadi 64,3 Km. Solusi ini juga mengurangi waktu pengiriman dari 1143,49 menit menjadi 1032,11 menit. Pengurangan jarak dan biaya juga akan mengurangi 56,48% biaya distribusi dari Rp.56.539 menjadi Rp. 31.717.
Mergers and Acquisitions in Brazilian Higher Education Companies
Authors: Silva Alan Willame de Souza , Junior Tabajara Pimenta , Soares Mara Alves , Gaio Luiz Eduardo , Ambrozini Marcelo Augusto
Published: April 2021

Purpose: The objective of this study is to detect and measure the occurrence of extraordinary returns to the shareholders of private higher education companies, listed on the Brazilian stock market, B3, when mergers and acquisitions occur.

Methods: This study uses the Event Study technique on process data from 46 merger and acquisition events, that occurred in the period of 2007- 2015, involving the three main Brazilian private higher education companies, and applies the Z-statistic to test the accumulated standard abnormal returns.

Results: Based on the results, it is possible to affirm that the presence of abnormal returns was not detected after merger and acquisition events. Events of this nature do not promote changes in the short-term value of the company, in the cases of large and publicly traded Brazilian private higher education companies.

Implications: The announcement of a merger or acquisition process has wide repercussions in the media and attracts the attention of investors that aims to gain abnormal earnings from anticipated post-merger value creation. This study showed that the potential gain in value does not always occur or is reflected in the stock prices of the companies involved, in the short term.
Measuring Hospitality and Tourism Management Students’ Satisfaction with Work Related Learning Using Partial Least Squares in Zimbabwe
Authors: Chakaipa Absai , Basera Vitalis , Chakaipa Memory , Dube Phamela
Published: April 2021

Purpose: The study assessed Tourism and Hospitality Students’ satisfaction with work-related learning (WRL) attachment using a two-stage extended model proposed by Taylor and Geldenhuys (2019). It also intends to determine if there are significant student satisfaction differences between males and females and between the students pursuing bachelor or diploma in Tourism and hospitality. Also, the study assessed if there is a moderation effect of a third variable (intermediate) on expectation and perception to students’ satisfaction.

Method: Data were collected from 488 students using a survey instrument at the onset and at the end of the attachment. Analysis of results was done using both SPSS 23 and R 4.0.3. The study also applied the Multi-Group Analysis-Partial Least Squares (MGA-PLS) analysis permutation to test students’ satisfaction.

Results: The research found no significant differences between males and females, and the students’ category (bachelor and diploma) on both Expectation-Satisfaction and Perception-Satisfaction relationship in model A. However, the study found significant differences between males and females in the perception-satisfaction relationship in Model B. The MGSA-PLS results revealed that male students have a positive and significant effect on the perception-satisfaction relationship as opposed to a negative and insignificant effect for females. The moderating effect test revealed that a third construct, INTER - Intermediate variable (a product of construct Perceptions and Expectation) has a positive impact on student satisfaction.

Implications: There is a need for collaboration between hospitality industry players and academics in curriculum design, so as to meet the demands of the industry.
Hastane Öncesi Acil Sağlık Hizmetleri ve COVID-19 Hasta Yönetimi
Authors: DURMUŞ Cengiz , GUNER Necip Gökhan , YURUMEZ Yusuf
Published: April 2021

COVID-19 hastalığının en dikkat çeken özelliği insandan insana çok hızlı bir şekilde bulaşabilmesidir. COVID-19 hastalarına müdahale ve nakil süreçlerinde yer alan hastane öncesi acil sağlık hizmetlerinde çalışan 112 ambulans ekibinin hastalığa yakalanma açısından en yüksek riske sahip gruplar arasında yer aldığı bilinmektedir. Bu yazıda hastane öncesi acil sağlık hizmetleri yönü ile COVID-19 hasta yönetimi ve bu alanda çalışan sağlık personeline yönelik riskler ve alınması gereken önlemlerden bahsedilmesi amaçlanmıştır.
The Influence of Age on the Relative Frequency of Super-Earths and Sub-Neptunes
Authors: Sandoval Angeli , Contardo Gabriella , David Trevor J.
Published: April 2021

There is growing evidence that the population of close-in planets discovered by the Kepler mission was sculpted by atmospheric loss, though the typical timescale for this evolution is not well-constrained. Among a highly complete sample of planet hosts of varying ages the age-dependence of the relative fraction of super-Earth and sub-Neptune detections can be used to constrain the rate at which some small planets lose their atmospheres. Using the California-Kepler Survey (CKS) sample, we find evidence that the ratio of super-Earth to sub-Neptune detections rises monotonically from 1 to 10 Gyr. Our results are in good agreement with an independent study focused on stars hotter than the Sun, as well as with forward modeling simulations incorporating the effects of photoevaporation and a CKS-like selection function. We find the observed trend persists even after accounting for the effects of completeness or correlations between age and other fundamental parameters.
Mitigating the Noise-source Coupling Effect in Shear Measurement
Authors: Li Hekun , Zhang Jun
Published: April 2021

Subpercent level accuracy in shear measurement is required by the Stage-IV weak lensing surveys. One important challenge is suppressing the shear bias on source images of low signal-to-noise ratios (S/N ≲ 10). Previously, it has been demonstrated that the shear estimators defined in the Fourier_Quad (FQ) method can achieve subpercent accuracy at the very faint end (S/N ≲ 5) through ensemble averaging. Later, it was found that we can approach the minimum statistical error (the Cramer–Rao Bound) by symmetrizing the full probability distribution function (PDF) of the FQ shear estimators (the PDF_SYM approach), instead of taking ensemble averages. Recently, with a large amount of mock galaxy images, we were able to identify some small amount of shear biases in the PDF_SYM approach at the faint end. The multiplicative bias goes up to (1–2) × 10−2 at S/N ≲ 10, and the anisotropy of the point-spread function causes an additive bias that can reach a few times 10−4. We find that these biases originate from the noise-source coupling in the galaxy power spectrum. It turns out that this problem can be largely fixed by adding additional terms to the FQ shear estimators. The resulting multiplicative and additive biases can be significantly suppressed to the level of 10−3 and 10−5, respectively. These corrections substantially extend the available S/N range for accurate shear measurement with the PDF_SYM approach.
deepCR on ACS/WFC: Cosmic-Ray Rejection for HST ACS/WFC Photometry
Authors: Kwon K. J. , Zhang Keming , Bloom Joshua S.
Published: April 2021

deepCR is a deep-learning-based cosmic-ray rejection algorithm previously demonstrated to be superior to state-of-the-art LACosmic on Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS)/WFC F606W imaging data. In this research note, we present a new deepCR model for use on all filters of HST ACS/WFC. We train and test the model with ACS/WFC F435W, F606W, and F814W images, covering the entire spectral range of the ACS optical channel. The global model demonstrates near 100% detection rates of CRs in extragalactic fields and globular clusters and 91% in resolved galaxy fields. We further confirm the global applicability of the model by comparing its performance against single-filter models that were trained simultaneously and by testing the global model on data from another filter which was not previously used for training.
The Simons Observatory: The Large Aperture Telescope (LAT)
Authors: Xu Zhilei , Adachi Shunsuke , Ade Peter , Beall J. A. , Bhandarkar Tanay , Bond J. Richard , Chesmore Grace E. , Chinone Yuji , Choi Steve K. , Connors Jake A. , Coppi Gabriele , Cothard Nicholas F. , Crowley Kevin D. , Devlin Mark , Dicker Simon , Dober Bradley , Duff Shannon M. , Galitzki Nicholas , Gallardo Patricio A. , Golec Joseph E. , Gudmundsson Jon E. , Haridas Saianeesh K. , Harrington Kathleen , Hervias-Caimapo Carlos , Patty Ho Shuay-Pwu , Huber Zachary B. , Hubmayr Johannes , Iuliano Jeffrey , Kaneko Daisuke , Kofman Anna M. , Koopman Brian J. , Lashner Jack , Limon Michele , Link Michael J. , Lucas Tammy J. , Matsuda Frederick , McCarrick Heather , Nati Federico , Niemack Michael D. , Orlowski-Scherer John , Piccirillo Lucio , Sarmiento Karen Perez , Schaan Emmanuel , Silva-Feaver Maximiliano , Sonka Rita , Sutariya Shreya , Tajima Osamu , Teply Grant P. , Terasaki Tomoki , Thornton Robert , Tucker Carole , Ullom Joel , Vavagiakis Eve M. , Vissers Michael R. , Walker Samantha , Whipps Zachary , Wollack Edward J. , Zannoni Mario , Zhu Ningfeng , Zonca Andrea ,   The Simons Observatory Collaboration
Published: April 2021

The Simons Observatory is a Cosmic Microwave Background experiment to observe the microwave sky in six frequency bands from 30 to 290 GHz. The Observatory—at ∼5200 m altitude—comprises three Small Aperture Telescopes and one Large Aperture Telescope (LAT) at the Atacama Desert, Chile. This research note describes the design and current status of the LAT along with its future timeline.
Pattern of postchemotherapy-associated complicatioins in a paediatric oncology service in Lagos
Authors: Akinsete Adeseye Michael , Fakile Ugonna Olaraiche , Nwobi Emmanuella Ijeoma , Awofeso Opeyemi Mercy
Published: April 2021

Background:

Globally, there is an increase in the number of pediatric oncology cases with significant morbidity and mortality in the low to middle income countries (LMIC) despite improved survival in the resource endowed nations. The increase in survival is largely due to the revolutionary use of multi strategy therapeutic interventions like chemotherapy, immunotherapy, surgery and radiotherapy. These modalities are however fraught with several complications. AIM The aim of this study was to prospectively observe and document the common complications following treatment of childhood cancers in a tertiary pediatric oncology unit in a resource constrained setting.

Methods:

This was a longitudinal observational study over a three-year period involving children with various cancers. Ethical approval was obtained from the hospital's human, research and ethics committee. A questionnaire was used to obtain socio-demographic data as well as details of adverse events encountered.

Results:

A total of 100 children enrolled in the study with acute lymphoblastic leukaemia been the commonest cancer. Gastrointestinal adverse events were the most common in the study cohort with alopecia rarely reported.

Conclusion:

Increased awareness of the common complications in this environment and prophylactic medications may improve the care of children post chemotherapy thereby reducing overall morbidity and cost of care.
Gastrointestinal stromal tumor experience in a surgical oncological unit in sub-Saharan Africa
Authors: Ayandipo Omobolaji O. , Ogun Gabriel O. , Ajagbe Oluwasanmi A. , Adegoke Omolade O. , Adepoju Olalekan J. , Rahman Adam , Ajuyah Chioma M. , Orunmuyi Akintunde T. , Shittu Olayiwola B.
Published: April 2021

Background:

Gastrointestinal stromal tumors (GISTs) are characterized by specific immunohistochemical and genetic features. This study investigated the clinicopathologic features and surgical outcomes of 54 patients with GIST in a major referral hospital in sub-Sahara Africa.

Methods:

This retrospective cross-sectional single-center study describes 54 patients who underwent surgery for GIST between 1999 and 2019 in a Nigerian Tertiary Hospital. All cases were confirmed by immunohistochemistry and were analyzed for clinical characteristics, clinical management, and histopathologic data. The risk of recurrence was determined using the Fletcher National Institutes of Health criteria.

Results:

The mean age of the patients was 57.6 years ± 15.3 (11–81 years), and most patients (67%) underwent abdominal computed tomography scans preoperatively. The most common presentation was an abdominal mass (48%). The stomach was the most common site of GIST (37%). The mean tumor size was 8.9 cm (5–18 cm), and tumor morphology showed spindle cell type (75.9%), mixed spindled-epithelioid (20.3%), and epithelioid (3.7%) cell types. Overall, 51% had a high risk for recurrence.

Conclusion:

The clinicopathologic features of GIST in this study are consistent with reports in the literature. Slight variations in risk profile may be due to late presentation in our settings.
Left Ventricular Function Assessment of Patients with Postoperative Ventricular Septal Defect Closure by Longitudinal Strain on Two-Dimensional Echocardiography 1 Year after Surgery
Authors: Banpurkar Ashish , Azad Sushil , Radhakrishnan Sitaraman , Garg Ankit
Published: April 2021

Background:

Patients with large perimembranous ventricular septal defects (pm-VSDs) undergo surgical repair with prosthetic material during infancy. However, the effect of the presence of akinetic patch in the ventricular septum on the left ventricular (LV) mechanical synchrony and ventricular function has not been studied. In our study, we assessed LV function in postoperative pm-VSD closure patients on two-dimensional (2D) echocardiography (echo) after 1 year of surgery using biplane Simspon's method, fractional shortening (FS), and global longitudinal strain (GLS) to assess the regional strain pattern.

Methods:

This was a a single-institution observational study. Patients following up 1 year after surgical ventricular septal defect closure at our institute were enrolled. On follow-up, detailed 2D echo was done with special emphasis on left atrial size, LV size (by M-mode), and presence of any residual shunt. LV function was assessed using biplane Simpson's method and longitudinal strain on 2D echo. GLS was measured in three standard apical views.

Results:

Of the 121 patients enrolled, 101 patients fulfilling the inclusion and exclusion criteria were analyzed. Of these 101 patients, 75.2% were males. The median age at follow-up after surgery was 3.67 ± 2.7 years. About 92.1% of patients did not have residual VSD lesion. No patient had pulmonary arterial hypertension. All except one patient had normal ventricular function. Patients with ventricular dysfunction had LV ejection fraction (LVEF) of 47%, GLS –17.4%, and FS −20.5%. The mean values of FS, LVEF, and GLS were 32.0 ± 5.28%, 62.2% ± 4.2%, and −26.53 ± 2.93%, respectively, in pm-VSD closure patients. Regional strain pattern analysis showed significantly lower strain values in basal anteroseptal segment with a mean of −21.4 ± 2.7%. FS and GLS were noted to have significant correlation with each other (P = 0.01) and LVEF by biplane Simpson's method and GLS had significant correlation with each other (P = 0.0001).

Conclusions:

GLS has strong correlation with LVEF by Simson's method and FS. Basal anteroseptal segment in pm-VSD patients had significantly lower strain values compared to other segments. There is no significant correlation between age at surgery and GLS in pm-VSD closure patients who were operated within 1 year of age. The type of VSD closure does not have significant influence on GLS.
A Case of Ebstein Anomaly with Left Ventricular Noncompaction and Anomalous Mitral Chordae to the Septum
Authors: Mishra Biswaranjan
Published: April 2021

Left-sided involvement is increasingly recognized in cases of Ebstein anomaly (EA) of tricuspid valve, thus making it not an exclusive right-sided disease, rather a global form of heart disease, a type of cardiomyopathy. Left-sided involvement commonly occurs in the form of noncompaction. Mitral valve prolapse and other forms of mitral and aortic valve abnormalities are also associated with EA that contribute to the patient's symptoms and prognosis. Here is a case report of EA in a 25-year-old female presenting with dyspnea. Echocardiography revealed left ventricular (LV) noncompaction fulfilling Jenni criteria. In addition, there was an abnormal chordal attachment from the anterolateral papillary muscle to the ventricular septum. There was no LV outflow obstruction, ventricular functions were normal. The combined involvement of LV myocardium and mitral apparatus in EA made this case unique in its category.
COVID-19 and Cardiac Health
Authors: Mani Avinash , Ojha Vineeta , Dubey Manoj Kumar
Published: April 2021

The ongoing novel coronavirus pandemic has caused a serious impact on patients suffering from cardiovascular disorders as they are predisposed to COVID infection as well as to exacerbation of their preexisting conditions which can prove to be fatal. Novel coronavirus disease-2019 (nCOVID-19) has a varied effect on the cardiac system ranging from myocardial injury to thromboembolic complications. A significant proportion of patients are noted to have comorbidities. Human angiotensin-converting enzyme 2 (ACE 2) receptor is considered the target of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). SARS-Cov-2 leads to imbalance in RAAS activity which is responsible for target organ damage. Recombinant ACE 2 has been shown to restore ACE 2 levels in explanted hearts and restore balanced RAAS activity. nCOVID-19 can have varied cardiac manifestations ranging from acute coronary syndrome to heart failure, arrhythmias, pulmonary thromboembolism, and pericarditis. The current nCOVID-19 pandemic has led to changes in management strategies for cardiovascular diseases. Patients with ST-elevation myocardial infarction can be fibrinolysed when a primary percutaneous coronary intervention facility with adequate protection is not available. Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker needs to be continued in patients with hypertension. Continuity of care for patients with chronic cardiovascular illness needs to be maintained. Management of cardiovascular emergencies needs to be done in a way which ensures the safety of health-care professionals and prevents infection transmission. Strict prevention of infection and health control measures will help to prevent spread of infection and reduce disease incidence.
Severe Hypertriglyceridemia with Recurrent Pancreatitis Treated with Therapeutic Plasma Exchange
Authors: Jain Anshul Kumar , Bedi Neha , Garg Anurag
Published: April 2021

Severe hypertriglyceridemia (HTG) is associated with an increased risk of cardiovascular disease and acute pancreatitis. We report the case of a 34-year-old female admitted with complaints of recurrent pancreatitis and triglyceride (TG) levels above 995 mg/dl. The patient was started on therapeutic plasma exchange (TPE) to achieve a rapid fall (78%) in serum TG levels. We conclude that TPE is a safe and quick therapeutic treatment modality for patients with HTG-induced recurrent acute pancreatitis who fail to respond to conventional therapy.
Video-assisted thoracoscopic surgery management of primary spontaneous pneumothorax
Authors: Puri Harsh Vardhan , Asaf Belal Bin , Pulle Mohan Venkatesh , Bishnoi Sukhram , Kumar Arvind
Published: April 2021

Background:

Primary spontaneous pneumothorax (PSP) results from the rupture of small blebs or bullae in a patient without any pre-existing lung disease. Last decade witnessed a paradigm shift in the surgical management of pneumothorax from open to video-assisted thoracoscopic surgery (VATS) method. In this study, we aim to report our single center experience of surgical management of PSP along with surgical outcomes in 110 consecutive cases of PSP.

Materials and Methods:

This is a retrospective study of 110 operated cases of PSP over 5 years. Demography, computed tomography findings, operative technique, endoscopic classification (Vanderschueren), surgical duration, intraoperative and postoperative complications, duration of Intercostal Drain (ICD), hospital stay, and recurrence in follow-up were recorded.

Results:

The average age of patients was 27.59 years (range 9–68 years). The average number of episodes before the presentation was 2 (range 1–5). The average number of loss of working days because of symptoms, conservative management, or long-term intercostal drainage was 13.33 days (range 5–60 days). As per intra-operative findings, patients were categorized as per Vanderschueren's classification and managed accordingly. Conversion rate was in 1.8% (n = 2). Mean time to removal of chest tubes was 4 days (2–12 days). Mean hospital stay was 3.83 days (2–9 days). There were no postoperative deaths. The mean follow-up was 25.05 months (6–60 months). Overall complication rate was 3.6% (n = 4) and recurrence happened in 2.7% (n = 3) cases.

Conclusions:

VATS is an efficient and safe treatment modality for PSP with low recurrence rates and high level of patient satisfaction.
MEDIA PEMBELAJARAN DI SMK SWASTA MELYAZ CINTA RAKYAT
Authors: Sadanah Meila Nida , Rusydi Rusydi , Zulham Zulham
Published: April 2021

Abstrak-Media berfungsi sebagai sarana pembelajaran individual yang membuat kedudukan, media juga dapat memfasilitasi kebutuhan belajar peserta didik secara mandiri. Pemakaian media pengajaran dalam proses belajar mengajar dapat membangkitkan keinginan dan minat yang baru, membangkitkan motivasi dan rangsangan kegiatan belajar. Selama melakukan penelitian di SMK Swasta Melyaz Cinta Rakyat, peneliti menemukan masalah sistem pada bagian proses pembelajaran di TSM (Teknik Sepeda Motor) biasanya untuk sebuah teori dilakukan di kelas dan untuk pratikum dilakukan di bengkel, berhubung pada saat ini lagi pandemi covid-19, siswa dilarang belajar antar tatap muka jadi siswa belajar melalui daring (online). Siswa pun jadi sulit untuk memahami teori tersebut karena terbiasa belajar secara langsung di bengkel tersebut. Oleh karena itu maka penulis mengusulkan suatu sistem media pembelajaran untuk jurusan TSM (Teknik Sepeda Motor) yang menggunakan Vb.Net untuk teori kelistrikan sepeda motor. Dengan adanya media pembelajaran ini maka siswa semakin mudah untuk memahami mata pelajaran tersebut. Hasil dari penelitian adalah sistem media pembelajaran kelistrikan sepeda motor yang dapat digunakan siswa untuk belajar dan digunakan guru untuk melakukan evaluasi dengan media pembelajaran. Kata Kunci : Sistem, Media Pembelajaran, Kelistrikan Sepeda Motor, Visual Basic
SISTEM INFORMASI INVENTORY BARANG PADA PT.MEDAN SMART JAYA BERBASIS WEB
Authors: Yusrizal Teuku , Hasugian Buyung Solihin , Yasir Amru
Published: April 2021

Abstrak- Saat ini perkembangan teknologi informasi berkembang cepat dan menuntut untuk menciptakan suatu aplikasi yang dapat menyelesaikan suatu permasalahan yang ada namun belum menemukan solusi. Pada proses mengetahui jumlah stok barang kadang akan mengalami kesulitan jika harus melakukan pengecekan secara manual. Aplikasi pada PT. Medan Smart Jaya ini didasarkan pada kebuhan pengelolaan informasi yang tepat dan akurat di dalam pengelolaan status barang yang berada di Gudang. Metodologi yang digunakan adalah metode waterfall, model ini menggambarkan pembangunan perangkat lunak seperti, mulai analysis requiment sebagai awal proses sampai dengen coding dan testing di akhir proses sebelum membuat sistem informasi ini , penulis merancang tabel-tabel yang dibutuhkan terlebih dahulu agar memudahakan dalam pembuatannya. Sistem informasi ini dibuat dengen menggunakan Bahasa pemrograman PHP,MySQL dan HTML sebagai database nya. Penulis menggunakan data flow diagram untuk merancang skema alur kerja sistem ini dan ERD untuk membuat hubungan relasi antar tabel. Hasil dari penelitian ini adalah membuat sistem informasi inventory barang berbasis web yang dapat mempermudah inventory dan mempercepat proses penyampaian informasi persediaan barang.Kata Kunci- Sistem Informasi, Inventory, Pemrograman PHP, MySQL,HTML, Basis data, Web.
Pengaruh Lingkungan Kerja, Stres Kerja, Pengawasan terhadap Semangat Kerja Karyawan (Studi pada CV. Bintang Tex Indonesia-Tulangan Sidoarjo)
Authors: Dewi Nafalina Sitta , Rosyafah Siti , Noviandari Indah
Published: April 2021

Ada beberapa faktor yang dapat mempengaruhi semangat kerja karyawan  antara lain: lingkungan kerja, stres kerja dan pengawasan. Penelitian ini bertujuan  untuk mengetahui dan membuktikan pengaruh lingkungan kerja, stres kerja, pengawasan terhadap semangat kerja karyawan (studi pada CV. Bintang Tex Indonesia-Tulangan Sidoarjo), secara simultan maupun parsial. Hasil penelitian menunjukan bahwa: lingkungan kerja, stress kerja dan pengawasan berpengaruh positif terhadap semangat kerja hal ini dibuktikan dengan nilai Fhitung> Ftabel (109.945 > 2,76) dan nilai signifikansi Fhitung sebesar 0,000. Lingkungan kerja berpengaruh positif terhadap semangat kerja hal ini dibuktikan dengan nilai thitung> ttabel (9.507 > 2.003) dan nilai signifikansi sebesar 0,000 < 0,05, stress kerja berpengaruh negative  terhadap semangat kerja hal ini dibuktikan dengan nilai thitung> ttabel (-3.183 > 2.003) dan nilai signifikansi sebesar 0,002 < 0,05, pengawasan  berpengaruh positif terhadap semangat kerja hal ini dibuktikan dengan nilai thitung> ttabel (3.276 > 2.003) dan nilai signifikansi sebesar 0,002 < 0,05. Lingkungan Kerja berpengaruh secara dominan terhadap Semangat Kerja Karyawan, hal ini dibuktikan oleh besarnya nilai 0,701 pada hasil pengujian parsial (uji t) nilai beta tertinggi.
Kualitas Pelayanan dan Kepuasan Masyarakat pada Kinerja Pegawai Menggunakan Metode Analysis GAP di Kantor Kecamatan Waru Kabupaten Sidoarjo
Authors: Indriani Sindy Devi , Pribadiyono Pribadiyono , Istanti Enny
Published: April 2021

Kantor Kecamatan Waru merupakan Suatu lembaga pemerintahan yang memberikan pelayanan kepada masyarakat, apabila layanan yang diberikan sesuai dengan yang diharapakan maka pelayanan tersebut berkualitas, bila tidak maka sebaliknya. Penilaian yang diberikan masyarakat menentukan kinerja pegawai. Tujuan penelian ini adalah untuk mengukur kualitas pelayanan di Kantor Kecamatan Waru Kabupaten Sidoarjo yang dilakukan dengan menggunakan metode Analysis gap. .Analisis kualitas pelayanan atau Service Quality (Servqual) yang meliputi lima dimensi yaitu : Tangibles (Bukti Fisik), Reliability (Kehandalan), Responsiveness (Daya Tanggap), Assurance (Jaminan), dan Empaty (Empati).. Berdasarkan hasil penelitian didapatkan Tangibles (Bukti Fisik) bernilai gap -0.40, Reliability (Kehandalan) bernilai gap -0.31, Responsiveness (Daya Tanggap) bernilai gap -0.35, Assurance (Jaminan) bernilai gap -0.42 dan Empaty (Empati) bernilai gap -0.47. Dalam lima dimensi tersebut perlu adanya peningkatan untuk memenuhi kepuasan masyarakat yaitu penambahan fasilitas toilet umum, pegawai selalu berpakaian seragam dan rapi, pegawai mampu memberikan alur petunjuk sesuai SOP (Prosedur), ketepatan waktu layanan serta pegawai senantiasa menjaga rahasia dokumen pengunjung.
Pengaruh Ukuran Perusahaan, Profitabilitas dan Resiko Bisnis terhadap Struktur Modal pada Perusahaan Manufaktur (LQ45) Tahun 2015-2018
Authors: Diastuti Savitri Ashifa , Cholifah Cholifah , Istanti Enny
Published: April 2021

Setiap lembaga maupun perusahaan pasti ada yang namanya manajemen keuangan.Manajemen keuangan sangat penting guna memantau dan melihat nilai dari sebuah lembaga maupun perusahaan.Penelitian ini bertujuan untuk menguji dan menganalisis apakah variabel Ukuran Perusahaan, Profitabilitas dan Resiko Bisnis berpengaruh secara simultan dan signifikan, berpengaruh secara parsial dan signifikan dan variabel mana yang berpengaruh dominan terhadap Struktur Modal. Metode pengambilan data yang digunakan dalam penelitian ini adalah purposive sampling dengan Populasi sebanyak 45 perusahaan dan 8 Perusahaan sebagai sampel. Penelitian ini menggunakan Teknik Analisis data regresi linier dibantu dengan Program SPSS 22. Hasil penelitian menunjukkan bahwa Ukuran Perusahaan, profitabilitas dan Resiko bisnis berpengaruh simultan dan signifikan terhadap Struktur Modal. Uji Parsial diperoleh Profitabilitas berpengaruh negatif dan signifikan, sedangkan ukuran perusahaan dan resiko bisnis berpengaruh positif dan signifikan terhadap struktur modal. Uji dominan diperoleh Resiko Bisnis memiliki nilai terbesar dibanding dengan variabel lain.
IMPROVING STUDENTS’ ACHIEVEMENT IN CREATING BROCHURE BY USING MEDIA OF ANIMATION VIDEO TO THE TENTH GRADE OF MIPA 1 SMA NEGERI 1 TONGAS PROBOLINGGO
Authors: Fatmawati Surya Dewi
Published: April 2021

This classroom action research was intended to improve the tenth grade students’ writing achievement in creating brochure at SMAN I Tongas Probolinggo by applying media of animation video. The respondents of this classroom Action research (CAR) were class XMIPA 1 that was determined purposively. The class XMIPA 1 were chosen as the subjects of this research because the class had more complicated problem dealing with writing and their average score in writing was the lowest among three existing classes that was 70.2 in the first semester. This CAR consisted of two cycles, in which each cycle covered four main stages including: the planning of the action, the implementation of the action, classroom observation. Meanwhile, the supporting data were gathered from interview and documentation. The result of the average score of the writing test in the first cycle was M=70,75 that was classified in the fair category. This result did not achieved the standard average score requirement in this research that was M≥75. Besides, based on the classroom observation that was done in the first cycle, it was found that the students’ involvement in the process of writing activities was 45%. Therefore, the actions were proceeded to the second cycle by revising the first action cycle such as: optimalizing the students’ participation in the process of writing activities, giving enough clues about the present tense ‘command sentences’, brochure and the way to apply media of animation video to the students. The results of the average score of the writing test in the second cycle was better M=75.86 that was classified in the good category. Besides, the students’ involvement in the writing process improved from 45% in the first cycle up to 84,6% in the second cycle. It means that both the students’ writing test and the students’ involvement in the writing process improved in the second cycle and fulfilled the target of this research. Based on the results, it could be concluded that the use of video animation media could improve the tenth st grade students’ writing achievement at SMAN I Tongas Probolinggo in two cycles. Then it is suggested to The English teacher to apply media of animation video as the alternative way of English teaching technique, especially in teaching writing a brochure. This is expected to facilitate and to help the students collaborate and share knowledge and experiences with their classmate to solve the writing problems.
Polioksimetilen Kopolimerinin Su Jeti Tezgâhlarında İşlenebilirliğinin Taguchi Metodu Kullanılarak Optimizasyonu
Authors: ALTINSOY Alirıza , ARSLAN Yusuf
Published: April 2021

Mühendislik polimeri olan polioksimetilen kopolimer (POM-C) yüksek çekme mukavemeti, aşınma direnci ve boyut kararlılığı gibi mekanik özelliklerinden dolayı günümüzde havacılık, otomotiv ve gemi sanayinde faaliyet gösteren birçok sanayi alanında kullanılmaktadır. Bu polimerler kullanım alanlarına göre şekillendirilmesi gerekmektedir. Şekillendirme yöntemlerden bir tanesi de su jeti tezgahlarıdır. Kesme sonrası, talaş oluşum sorununu ortadan kaldırması nedeniyle su jeti ile kesme genelde çok sert ve kırılgan olmayan malzemeler için uygundur. Polimerler, bu malzeme grubuna girmemekle birlikte, kesme işlemi esnasında yüksek ısıların oluşmaması bundan dolayı polimerlerin yapısal olarak bozulmaması, daha küçük ve karmaşık şekillerin rahatlıkla işlenmesi, su jeti ile üretimin, diğer üretim metodlarına göre daha hızlı olması, aynı zamanda mühendislik polimerlerinin pahalı olması, uygulanan metotta daha az malzemenin israf olması polimerlerin su jeti tezgahlarında işlenmesinin başlıca sebeplerindendir. Bu çalışmada polioksimetilen kopolimerine 210, 260, 310 MPa basınçta üç farklı ilerleme hızı ( 170, 240, 380 mm/dk), üç farklı aşındırıcı garnet miktarı (150, 250, 350 g/dk) su jeti tezgâhında kesme işlemi gerçekleştirilmiştir. Deney sonuçlarındaki veriler sinyal - gürültü oranı (S/N), ANOVA analizi, ve regresyon yöntemi uygulanarak incelenmiştir. Yapılan çalışma sonuçlarında su jeti tezgâhında 260 MPa basınçta 350 g/dk garnet miktarı 170 mm/dk ilerleme hızında yüzey pürüzlülüğünün diğer parametrelere göre daha düşük çıktığı, ilerleme hızının su jeti tezgahlarında en etkin parametre olduğu bulunmuştur.
TEACHERS’ AND STUDENTS’ OPINIONS ABOUT THE REASONS OF SECONDARY EDUCATION STUDENTS’ ABSENTEEISM IN EUROPE AND TURKEY
Authors: DEMİRCİ Cavide , TUNÇ TOPTAŞ Hilal
Published: April 2021

This work is a study of the convergent pattern of mixed methods research that combines quantitative and qualitative research methods to assess teachers’ and students’ opinions based on the reason of secondary education students’ absenteeism in Europe and Turkey. The study sample is 10 teachers (two from each country) working in high schools in Turkey, Iceland, Austria, Czech Republic, and Spain, and 155 students are studying in those teachers’ schools determined by using purposive sampling method to access them easily. A semi-structured interview form was used in the interviews with 10 teachers. The data collection tool applied to 155 students is the " "The Scale of Absenteeism Causes." Descriptive analysis technique was used in the analysis of qualitative data. In the analysis conducted of the study, it is observed that there is a difference between the reasons for absenteeism of boys and girls. A significant difference was found between the reasons for absenteeism of the students according to the country they live in. According to teachers, student absenteeism originates from school, students, psychology, and parents. Also, teachers' suggestions to reduce students' absenteeism and early school leaving were included in the interview form and evaluated in the analysis part of the study
Activación de los músculos escapulohumerales superficiales en tres planos distintos de elevación del hombro
Authors: Palma Felipe H , Cifre Manuela J , Clemo Mancilla Ignacio , Flores-León Andrés , Guzmán-Venegas Rodrigo
Published: April 2021

Objetivo: Comparar la actividad electromiográfica de la musculatura superficial escapulohumeral entre los tres planos de elevación de hombro: sagital, escapular y frontal. Métodos: Se realizó un estudio observacional, analítico, de corte transversal. Trece participantes realizaron una elevación y descenso de hombro en los tres planos. Durante estas elevaciones, se midió la cinemática del hombro con un sistema de captura de movimiento 3D. Sincrónicamente, se registró la actividad electromiográfica del músculo serrato anterior, de las tres porciones del músculo deltoides (anterior, medio y posterior) y trapecio (superior, medio e inferior). Se comparó la actividad muscular entre los tres planos a través de una prueba de Friedman o Skillings-Mack, según ausencia o presencia de datos perdidos. Resultados: Las porciones anterior y posterior del músculo deltoides (anterior y posterior) y el trapecio medio mostraron diferencias entre los planos de elevación (p<0.05). La porción media del deltoides se activó más en el plano frontal, al inicio de la elevación (p<0.05). Los demás músculos no mostraron diferencias entre los distintos planos. Conclusión: Los músculos deltoides anterior y posterior y trapecio medio modifican su activación en la elevación de hombro en distintos planos. Esta información puede orientar la selectividad muscular de ejercicios utilizados en la rehabilitación de la articulación escapulohumeral.
Omega-6 fatty acids and the Risk of Cardiovascular Disease: Insights from a Systematic Review and Meta-Analysis of Randomized Controlled Trials and a Mendelian Randomization Study.
Authors: Mazidi Mohsen , Shekoohi Niloofar , Katsiki Niki , Banach Maciej , Meta-analysis Collaboration (LBPMC) Group the Lipid and Blood Pressure
Published: April 2021

Introduction

The effects of omega-6 PUFAs on the CV risk factors are still controversial. Thus, we performed a systematic review and meta-analysis of RCTs as well as a Mendelian Randomization analysis to evaluate the links and possible causality between omega-6 PUFA, CVD and cardiometabolic risk factors.

Material and methods

Selected databases were searched until September 2019 to identify prospective studies investigating the effects of omega-6 PUFAs supplementation on CVD events/mortality. Random-effects model meta-analysis was performed for quantitative data synthesis. Trial sequential analysis (TSA) was used to evaluate the optimal sample size to detect a 20% reduction in outcomes after administration of omega-6 PUFAs. Inverse variance weighted method (IVW), weighted median-based method, MR-Egger and MR-PRESSO were applied for MR.

Results

The pooled estimate risk ratio (RR) of omega-6 PUFAs supplementation was 0.94 for any CVD event (95%CI:0.77-1.15, I2=66.2%), 1.06 for CVD death (95%CI:0.73-1.55, I2=66.2%), 0.84 for coronary heart disease (CHD) events (95%CI:0.61-1.16, I2=79.4%), 0.87 for myocardial infarction (MI) (95%CI:0.74-1.01, I2=2.3%) and 1.36 for stroke (95%CI:0.45-4.07, I2=55.3%). In contrast, MR showed that individuals with higher serum adrenic acid (AA) levels had a greater risk for CHD events (IVW=Beta:0.526), MI (IVW=Beta:0.606) and large artery stroke (IVW=Beta:1.694), as well as increased levels of FBG (IVW=Beta:0.417), LDL-C (IVW=Beta:0.806,) HDL-C (IVW=Beta:0.820), and lower levels of triglycerides (TG) (IVW=Beta:-1.064) and total cholesterol (TC) (IVW=Beta:-1.064).

Conclusions

Omega-6 PUFAs supplementation did not affect the risk for CVD morbidity and mortality. Additionally, in MR analysis we showed that higher AA levels might even significantly increase with the risk of CHD, MI and large artery stroke.
INFLUÊNCIA DO EXERCÍCIO FÍSICO SOB O SISTEMA IMUNOLÓGICO: UMA REVISÃO BIBLIOGRÁFICA.
Authors: Costa Elói Samuel Torres , Lima Thamires Souza , Machado Gleise Da Câmara Correia
Published: April 2021

Introdução: No último século observou-se que a população dos países desenvolvidos e em desenvolvimento está se tornando fisicamente menos ativa, afetando negativamente a expectativa e qualidade de vida dessas populações, além da redução de exercícios físicos contribuírem para tal efeito, outros fatores são capazes de modificar o comportamento do sistema imunológico prejudicando a saúde do indivíduo, tais como: idade, fatores genéticos, metabólicos, ambientais, anatómicos, fisiológicos, nutricionais e microbiológicos. O destaque ao exercício físico justifica-se por tratar-se de um fator de risco modificável. Objetivo: descrever a influência dos exercícios físicos sob o sistema imunológico e suas implicações sob a saúde. Metodologia: O presente estudo trata-se de uma revisão bibliográfica da literatura realizada nas bases de dados indexadas a Biblioteca Virtual em Saúde (BVS) utilizando os descritores em português indexados ao DeCS: exercício físico, sistema imunológico e saúde associados ao operador booleano “and". Os critérios de inclusão foram textos completos disponíveis na íntegra nos idiomas inglês, português e espanhol publicados entre 2016 e 2021, que abordassem o tema em questão. Resultados: Na busca, utilizando os descritores, foi encontrado um total de 55 publicações, após a inserir os critérios de inclusão restaram 13 publicações que atendiam os critérios, das quais 8 estavam indexadas na MEDLINE e 5 na LILACS, após a leitura dos resumos e do texto na íntegra foram incluídos 5 artigos para a elaboração do presente estudo. Conclusão: É possível sugerir que exercícios físicos aeróbicos de intensidade moderada tem influenciado o sistema imune gerando neuroproteção contra altas concentrações de amônia no cérebro e também a modulação de marcadores inflamatórios e tem se mostrado uma importante ferramenta no manejo de alterações no sistema imunológico.
MANEJO DA SÍNDROME DE FELTY: TERAPIAS PROPOSTAS E DESAFIOS ENCONTRADOS
Authors: Cabral Anna Julie Medeiros , Lima Camila Araújo Novais , Filho Eduardo Franco Correia Cruz , Alves Fernanda Araújo , Soares Gabriel Lucena De Carvalho
Published: April 2021

Introdução: A Síndrome de Felty (SF) é uma manifestação extra-articular da artrite reumatoide que inclui a neutropenia e esplenomegalia. O objetivo do tratamento é reduzir a dor e retardar uma maior quantidade de danos, visto que, não há estudos de ensaios clínicos randomizados, sendo o manejo terapêutico da literatura advindo de relatos de casos. Objetivos: Abordar os manejos terapêuticos da SF descritos na literatura. Material e Métodos: Trata-se de uma revisão de literatura integrativa, retrospectiva, qualitativa, com intuito descritivo de estudos nacionais e internacionais da base de dados PubMed. A fórmula de busca utilizou as palavras-chave do artigo, com o operador booleano “OR”, resultando em 42 artigos nos últimos 5 anos. Após aplicação de critérios de inclusão e exclusão, restaram 26 artigos, dentre os quais, 6 foram escolhidos para compor esta revisão por melhor se relacionarem ao tema. Resultados: O tratamento de primeira linha mencionado em 83,5% (n=5) dos artigos incluiu o metotrexato (MTX), pelo seu mecanismo de ação na neutropenia, além da ação na prevenção na recorrência da infecção. Outros medicamentos antirreumáticos modificadores da doença (DMARD) foram citados nos artigos, como a leflunomida, inibidores de fator de necrose tumoral e terapia parental de ouro (não mais utilizada hoje). O agente biológico rituximabe, anticorpo monoclonal contra o antígeno CD20, demonstrou boa opção para SF refratária. Os glicocorticóides podem ser utilizados em terapias a curto prazo, fornecendo uma melhora rápida na contagem de neutrófilos, mas devem ser evitados a longo prazo. O uso de fator estimulador de colônias de granulócitos (G-SFC) foi indicado para quantidade inferior a 1000/mm3 de neutrófilos absolutos. Outro artigo, relatou sobre a consequência do sequestro esplênico, recomendando a esplenectomia para os casos mais graves de esplenomegalia. Conclusão: Portanto, o manejo terapêutico da SF possui diversas vertentes direcionadas por estudos observacionais, sendo necessário a realização de ensaios clínicos e novas pesquisas no âmbito científico, para consolidar a melhor terapêutica para a síndrome.
POLI-N-ACETIL-D-GLUCOSAMINA (PNAG) EM BACTÉRIAS: UMA REVISÃO DE LITERATURA
Authors: Veríssimo Graciete Soares Libório , Ristow Paula Carvalhal Lage Von Buettner
Published: April 2021

Introdução: Poli-N-acetil-D-glucosamina (PNAG), é um exopolissacarídeo presente na cápsula de muitas espécies bacterianas. É formado por resíduos de N-acetil-D-glucosamina (GlcNAc), unidos por ligações β (1-6), parcialmente desacetilado. Objetivo: Abordar os principais aspectos de PNAG em espécies bacterianas, desde a sua biossíntese às possíveis aplicações biotecnológicas. Material e métodos: Consistiu-se em uma revisão de literatura, a partir de uma abordagem qualitativa, na base de dados Pubmed, utilizando como termo de busca a palavra PNAG. Foram encontrados 160 artigos, compreendendo o período de 2000 a 2020. Resultados: De acordo com os dados da literatura, PNAG é expresso por mais de 40 espécies de bactérias divididas em 28 gêneros bacterianos. A maioria bactérias Gram-negativas e patogênicas. Como polissacarídeo presente na cápsula, PNAG fornece proteção da morte fagocítica mediada pelo complemento. PNAG também compõem a matriz extracelular do biofilme de muitas espécies bacterianas, contribuindo para adesão a superfícies e integridade estrutural do biofilme. PNAG foi identificado como um importante fator de virulência, contribuindo para adesão, colonização, evasão do sistema imune, resistência a antibioticoterapia, proteção contra estresse ambiental, além de contribuir para viabilidade celular. Por ser um polissacarídeo capsular conservado presente em muitas bactérias de importância clínica é considerado um importante alvo vacinal. De acordo com estudos publicados, tanto uma vacina (AV0328) como um anticorpo direcionado especificamente a PNAG (mAb F598) foram desenvolvidos, testados com êxito em animais e estão em ensaios clínicos humano. Conclusão: Por ser PNAG um polissacarídeo conservado e expresso por inúmeras bactérias patogênicas, um horizonte de possibilidades futuras é aberto, onde PNAG poderá contribuir para uma melhora nos tratamentos imunoterapêuticos e na prevenção de inúmeras doenças infecciosas através de uma vacina. No entanto, ainda é necessária uma melhor compreensão do papel de PNAG na biologia microbiana, desde a diversidade genética e enzimática envolvidas em sua síntese nas diferentes espécies bacterianas; seu papel na formação de cápsula e biofilme, assim como a ampla proteção que ele fornece contra diferentes bactérias.