bluuebunny/crossref_metadata_2025 huggingface dataset:
Using fluorescence lifetime microscopy to study the subcellular localization of anthocyanins
Authors: Chanoca Alexandra , Burkel Brian , Kovinich Nik , Grotewold Erich , Eliceiri Kevin W. , Otegui Marisa S.
Published: August 2016

Anthocyanins are flavonoid pigments that accumulate in most seed plants. They are synthesized in the cytoplasm but accumulate inside the vacuoles. Anthocyanins are pigmented at the lower vacuolar pH, but in the cytoplasm they can be visualized based on their fluorescence properties. Thus, anthocyanins provide an ideal system for the development of new methods to investigate cytoplasmic pools and association with other molecular components. We have analyzed the fluorescence decay of anthocyanins by fluorescence lifetime imaging microscopy (FLIM), in both in vitro and in vivo conditions, using wild‐type and mutant Arabidopsis thaliana seedlings. Within plant cells, the amplitude‐weighted mean fluorescence lifetime (τm) correlated with distinct subcellular localizations of anthocyanins. The vacuolar pool of anthocyanins exhibited shorter τm than the cytoplasmic pool. Consistently, lowering the pH of anthocyanins in solution shortened their fluorescence decay. We propose that FLIM is a useful tool for understanding the trafficking of anthocyanins and, potentially, for estimating vacuolar pH inside intact plant cells.
FTY720P inhibits hepatic Na+–K+ATPase via S1PR2 and PGE2
Authors: Al Alam Nadine , Kreydiyyeh Sawsan Ibrahim
Published: August 2016

Sphingosine-1-phosphate (S1P) was found previously to inhibit Na+–K+ATPase in HepG2 cells. Whether fingolimod (FTY720), a S1P receptor (S1PR) agonist, similarly inhibits the ATPase is a question that needs to be addressed. The aim of this work was to study the effect of FTY720P, the active form of the drug, on the activity of Na+–K+ATPase in HepG2 cells and determine its mechanism of action. The activity of the ATPase was assayed by measuring the amount of inorganic phosphate liberated in the presence and the absence of ouabain. FTY720-P (7.5 nmol/L, 15 min) significantly reduced the activity of the ATPase. This effect disappeared completely in the presence of JTE-013, which is a specific blocker of sphingosine-1-phosphate receptor 2 (S1PR2), as well as in the presence of calphostin and indomethacin, which are inhibitors of protein kinase C (PKC) and COX-2, respectively. The effect of FTY720P was mimicked by prostaglandin E2 (PGE2) and PMA, but abrogated by NF-κB inhibition. When NF-κB was inhibited, the effect of exogenous PGE2 still appeared, but that of PMA did not manifest, suggesting that NF-κB is upstream of PGE2 and downstream of PKC. It was concluded that FTY720P activates via S1PR2, PKC, and NF-κB. The latter induces PGE2 generation and inhibits Na+–K+ATPase.
Bird Strike Modeling in Fiber-Reinforced Polymer Composites
Authors: Donadon Maurício V. , Arbelo Mariano A.
Published: August 2016

The present paper describes a numerical modeling approach to predict impact resistance and residual Shear Strength After Impact (SSAI) of fiber reinforced polymer composites subjected to bird strike loading. An improved damage mechanics based on material model, previously developed by the authors, is combined with an equation of state to simulate the progressive failure in composite aerostructures subjected to bird strike loading. A series of bird strike impacts on flat panels fabricated from low cost woven glass composite materials are used to validate the material model for practical composite component applications. A numerical study on the residual SSAI of a typical composite shear web is also presented. The panels are modelled with shell elements only. The proposed material model formulation accounts for the strain rate enhancement to strength and shear nonlinearities observed in composite materials. A hydrodynamic model for the bird, based on 90% water and 10% air, is derived to represent the behavior of the bird for all impact scenarios considered. The bird is heterogeneous in nature. However, a uniform material behavior is assumed with a geometry based on a 2:1 length to diameter ratio with a cylindrical body and spherical end caps using Lagrangian mesh. Appropriate contact definitions are used between the bird and the composite panel. The simulations results are compared to experimental results and conclusions drawn.
Lattice strain driven dielectric insulation response of Sr1−xCaxBi2Nb2O9 ceramics
Authors: Shrivastava Vaibhav
Published: August 2016

In this paper, effects of lattice strain on dielectric properties of Sr[Formula: see text]CaxBi2Nb2O9 ([Formula: see text]–0.5 in steps of 0.1) ceramics are reported. High frequency dipolar polarization is observed to increase for 10% calcium addition and suppresses thereafter on higher calcium concentrations. The dielectric loss values for all doped samples were lower compared to undoped one at frequencies beyond 1[Formula: see text]kHz. The sample with [Formula: see text] shows room temperature dielectric constant in the range (130[Formula: see text][Formula: see text][Formula: see text]12) over a wide frequency range from 50[Formula: see text]Hz to 1[Formula: see text]MHz also minimum dielectric loss among all other sample for the same frequency range. Remarkable increase in Curie temperature ([Formula: see text]) by 50[Formula: see text]C is recorded in the present work by increasing 10% calcium content in SBN compostion. All higher doped samples indicate increase in [Formula: see text] by further higher amount. In addition, dc conductivity of all samples is measured for all samples and increase in calcium content is observed to generate more insulating compositions compared to undoped SBN with higher intrinsic activation energies.
Simple Parallel and Distributed Algorithms for Spectral Graph Sparsification
Authors: Koutis Ioannis , Xu Shen Chen
Published: August 2016

We describe simple algorithms for spectral graph sparsification, based on iterative computations of weighted spanners and sampling. Leveraging the algorithms of Baswana and Sen for computing spanners, we obtain the first distributed spectral sparsification algorithm in the CONGEST model. We also obtain a parallel algorithm with improved work and time guarantees, as well as other natural distributed implementations. Combining this algorithm with the parallel framework of Peng and Spielman for solving symmetric diagonally dominant linear systems, we get a parallel solver that is significantly more efficient in terms of the total work.
Unlocking the secrets of cell membranes
Authors: Askhar Rana
Published: August 2016

Biological cell membranes are dynamic structures capable of carrying out diverse functions, functions which are controlled by the dynamic organization and interactions of the membrane's main building blocks, i.e., lipids and proteins. Indeed, over the last decades, a large body of research has been focused on understanding the interactions between lipids and proteins, and how they control critical cellular functions such as signal transduction, cell trafficking, and host-pathogen interactions. There is increasing evidence that the dynamic nature of lipids and proteins, and their organization into functional domains within cell membranes is directly responsible for a wide range of vital biological processes. Much of this evidence is made possible by computer simulations that can tease out the atomic details of the different biomolecules making up cell membranes, and provide insights into the nano- and mesoscale structural and dynamical features that impart function. Results of such simulations have opened new avenues for understanding pathogenic pathways and designing advanced therapeutics.
Review of "Undoing the demos: Neoliberalism's Stealth revolution" by Wendy Brown
Authors: Crenshaw Nicole
Published: August 2016

A review of the book Neoliberalism's Stealth Revolution, written by the American political scientist Wendy Brown.
Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog
Authors: Freedman Adam H. , Lohmueller Kirk E. , Wayne Robert K.
Published: August 2016

The dog is our oldest domesticate and has experienced a wide variety of demographic histories, including a bottleneck associated with domestication and individual bottlenecks associated with the formation of modern breeds. Admixture with gray wolves, and among dog breeds and populations, has also occurred throughout its history. Likewise, the intensity and focus of selection have varied, from an initial focus on traits enhancing cohabitation with humans, to more directed selection on specific phenotypic characteristics and behaviors. In this review, we summarize and synthesize genetic findings from genome-wide and complete genome studies that document the genomic consequences of demography and selection, including the effects on adaptive and deleterious variation. Consistent with the evolutionary history of the dog, signals of natural and artificial selection are evident in the dog genome. However, conclusions from studies of positive selection are fraught with the problem of false positives given that demographic history is often not taken into account.
Vibration Characteristics of Roundabout Swing of HAWT Wind Wheel
Authors: Ma Jian-long , Li Pei-lin , Wang Jian-wen , Yang Liu , Zhang Yan-qi
Published: August 2016

Modal testing was used to show that the roundabout swing was a natural vibration mode of the wind wheel of a horizontal-axis wind turbine (HAWT). During the vibration, the blade root was simultaneously subjected to bending and rotary shear stresses. A method for indirect testing and determination of the dynamic frequencies of the typical vibrations of the wind wheel was developed, based on the frequency-holding characteristic of each subsignal during the transmission of the multiple mixed-vibration signals. The developed method enabled simple and accurate acquisition of the dynamic frequencies without destruction of the flow and structural fields. The dynamic vibration stress of the roundabout swing was found to be significantly stronger than those of the first- and second-order flexural vibrations of the blades. By a combination of numerical simulations and tests, it was determined that the pneumatic circumferential force was the primary determinant of the roundabout swing vibration frequencies, the relationship being quadratic. The roundabout swing vibration potentially offers new explanations and analytical pathways regarding the behavior of horizontal-axis wind turbines, which have been found to be frequently involved in fatigue-damage accidents within periods shorter than their design lives.
Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review
Authors: Nevoral Jan , Bodart Jean-Francois , Petr Jaroslav
Published: August 2016

Creation of both gametes, sperm and oocyte, and their fusion during fertilization are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization, and early embryonic development are still subjected to intensive study, a lot of phenomena remain unclear. Based on our best knowledge and own results, we consider gasotransmitters to be essential for various signalisation in oocytes and embryos. In accordance with nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO‐ and H2S‐derived posttranslational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.
Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
Authors: Bandera Merchan Borja , Tinahones Francisco José , Macías-González Manuel
Published: August 2016

The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPARϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.
Semianalytic Solution of Space-Time Fractional Diffusion Equation
Authors: Elsaid A. , Shamseldeen S. , Madkour S.
Published: August 2016

We study the space-time fractional diffusion equation with spatial Riesz-Feller fractional derivative and Caputo fractional time derivative. The continuation of the solution of this fractional equation to the solution of the corresponding integer order equation is proved. The series solution of this problem is obtained via the optimal homotopy analysis method (OHAM). Numerical simulations are presented to validate the method and to show the effect of changing the fractional derivative parameters on the solution behavior.
Short‐Term Effects of Chlorpromazine on Oxidative Stress in Erythrocyte Functionality: Activation of Metabolism and Membrane Perturbation
Authors: Ficarra Silvana , Russo Annamaria , Barreca Davide , Giunta Elena , Galtieri Antonio , Tellone Ester
Published: August 2016

The purpose of this paper is to focus on the short‐term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic effects or complications due to chlorpromazine, but most of these studies explore the influence of long‐term treatment. We think that evaluating the short‐term effects of the drug may help to clarify the sequence of chlorpromazine molecular targets from which some long‐term effects derive. Our results indicate that although the drug is primarily intercalated in the innermost side of the membrane, it does not influence band 3 anionic flux, lipid peroxidation, and protein carbonylation processes. On the other hand, it destabilizes and increases the autooxidation of haemoglobin, induces activation of caspase 3, and, markedly, influences the ATP and reduced glutathione levels, with subsequent exposure of phosphatidylserine at the erythrocyte surface. Overall our observations on the early stage of chlorpromazine influence on erythrocytes may contribute to better understanding of new and interesting characteristics of this compound improving knowledge of erythrocyte metabolism.
Research on Bridge Sensor Validation Based on Correlation in Cluster
Authors: Xiaowei Huang , Peng Zhang , Pinyi Ding , Weimin Chen , Fei Xiong
Published: August 2016

In order to avoid the false alarm and alarm failure caused by sensor malfunction or failure, it has been critical to diagnose the fault and analyze the failure of the sensor measuring system in major infrastructures. Based on the real time monitoring of bridges and the study on the correlation probability distribution between multisensors adopted in the fault diagnosis system, a clustering algorithm based onk-medoid is proposed, by dividing sensors of the same type intokclusters. Meanwhile, the value ofkis optimized by a specially designed evaluation function. Along with the further study of the correlation of sensors within the same cluster, this paper presents the definition and corresponding calculation algorithm of the sensor’s validation. The algorithm is applied to the analysis of the sensor data from an actual health monitoring system. The result reveals that the algorithm can not only accurately measure the failure degree and orientate the malfunction in time domain but also quantitatively evaluate the performance of sensors and eliminate error of diagnosis caused by the failure of the reference sensor.
Characterization of Al-Doped ZnO Transparent Conducting Thin Film Prepared by Off-Axis Magnetron Sputtering
Authors: Ou Sin-Liang , Lai Feng-Min , Yuan Lun-Wei , Cheng Da-Long , Kao Kuo-Sheng
Published: August 2016

The off-axis sputtering technique was used to deposit Al-doped ZnO (AZO) films on glass substrates at room temperature. For the illustration of the sample position in the sputtering chamber, the value ofR/ris introduced. Here,ris the radius of AZO target and R is the distance between the sample and the center of substrate holder. A systematic study for the effect of deposition parameters on structural, optical, and electrical properties of AZO films has been investigated in detail. As the sample position ofR/ris fixed at 1.8, it is found that the as-deposited AZO film has relatively low resistivity of 2.67 × 10−3 Ω-cm and high transmittance above 80% in the visible region. Additionally, after rapid thermal annealing (RTA) at 600°C with N2atmosphere, the resistivity of this AZO film can be further reduced to 1.19 × 10−3 Ω-cm. This indicates the AZO films prepared by off-axis magnetron sputtering and treated via the appropriate RTA process have great potential in optoelectronic applications.
Endoscopic Resection of a Pedunculated Brunner’s Gland Hamartoma of the Duodenum
Authors: Iwamuro Masaya , Tanaka Takehiro , Ando Satoko , Gotoda Tatsuhiro , Kanzaki Hiromitsu , Kawano Seiji , Kawahara Yoshiro , Okada Hiroyuki
Published: August 2016

A 68-year-old Japanese woman presented with a solitary pedunculated polyp in the duodenum. Endoscopic ultrasonography showed multiple cystic structures in the polyp. The polyp was successfully resected by endoscopic snare polypectomy and pathologically diagnosed as Brunner’s gland hamartoma. Because hamartomatous components were not identified in the stalk of the polyp, we speculate that the stalk developed from traction of the normal duodenal mucosa. When a solitary, pedunculated polyp with cystic structure within the submucosa is found in the duodenum, Brunner’s gland hamartoma should be considered in the differential diagnosis, despite the rarity of the disease. This case underscores the usefulness of endoscopic ultrasonography for the diagnosis of duodenal subepithelial tumors.
Array Mutual Coupling Reduction Using L-Loading E-Shaped Electromagnetic Band Gap Structures
Authors: Jiang Tao , Jiao Tianqi , Li Yingsong
Published: August 2016

A mutual coupling reduction method between microstrip antenna array elements is proposed by using periodic L-loading E-shaped electromagnetic band gap structures. Two identical microstrip patch antennas at 2.55 GHz are settled together and used to analyze the performance of the designed two-element antenna array. The two antenna elements are settled with a distance of about0.26λ. To reduce the mutual coupling, the L-loading E-shaped electromagnetic band gap structures are used between these antenna elements. The simulated and measured results show that the isolation of the antenna array reaches 38 dB, which has a mutual coupling reduction of 26 dB in comparison with the antenna array without the decoupling structures.
Tree Species Diversity, Richness, and Similarity in Intact and Degraded Forest in the Tropical Rainforest of the Congo Basin: Case of the Forest of Likouala in the Republic of Congo
Authors: Ifo Suspense Averti , Moutsambote Jean-Marie , Koubouana Félix , Yoka Joseph , Ndzai Saint Fédriche , Bouetou-Kadilamio Leslie Nucia Orcellie , Mampouya Helischa , Jourdain Charlotte , Bocko Yannick , Mantota Alima Brigitte , Mbemba Mackline , Mouanga-Sokath Dulsaint , Odende Roland , Mondzali Lenguiya Romarick , Wenina Yeto Emmanuel Mampouya , Ouissika Brice Chérubins , Joel Loumeto Jean
Published: August 2016

Trees species diversity, richness, and similarity were studied in fifteen plots of the tropical rainforests in the northeast of the Republic of Congo, based on trees inventories conducted on fifteen 0.25 ha plots installed along different types of forests developed on terra firma, seasonally flooded, and on flooded terra. In all of the plots installed, all trees with diameter at breast height, DBH ≥ 5 cm, were measured. The Shannon diversity index, species richness, equitability, and species dominance were computed to see the variation in tree community among plots but also between primary forest and secondary forest. A total of 1611 trees representing 114 species and 35 families were recorded from a total area of 3.75 ha. Euphorbiaceae was the dominant family in the forest with 12 species, followed by Fabaceae-Mimosoideae (10 species) and Phyllanthaceae (6 species) and Guttiferae (6 species). The biodiversity did not vary greatly from plot to plot on the whole of the study area (3.75 ha). The low value of Shannon index was obtained in plot 11 (H′=0.75) whereas the highest value was obtained in plot 12 (H′=4.46). The values of this index vary from 0.23 to 0.95 in plots P11 and P15, respectively. Results obtained revealed high biodiversity of trees of the forest of Impfondo-Dongou. The information on tree species structure and function can provide baseline information for conservation of the biodiversity of the tropical forest in this area.
Climatological Characteristics of Heavy Rainfall in Northern Pakistan and Atmospheric Blocking over Western Russia
Authors: Yamada Tomohito J. , Takeuchi Daiki , Farukh M. A. , Kitano Yoshikazu
Published: August 2016

Pakistan and northwestern India have frequently experienced severe heavy rainfall events during the boreal summer over the last 50 years including an event in late July and early August 2010 due to a sequence of monsoon surges. This study identified five dominant atmospheric patterns by applying principal component analysis and k-means clustering to a long-term sea level pressure dataset from 1979 to 2014. Two of these five dominant atmospheric patterns corresponded with a high frequency of the persistent atmospheric blocking index and positive sea level pressure over western Russia as well as an adjacent meridional trough ahead of northern Pakistan. In these two groups, a negative sea surface temperature anomaly was apparent over the equatorial mid- to eastern Pacific Ocean. The heavy precipitation periods with high persistent blocking frequency in western Russia as in the 2010 heat wave tended to have 1.2 times larger precipitation intensity compared to the whole of the heavy precipitation periods during the 36 years.
Fever in the archive
Authors: Haebich Anna
Published: August 2016

Biography is a metaphor for this critical study of a major Australian archive that holds the records of government departments responsible for the administration of Aboriginal affairs in Western Australian from 1897 to 1972. This artefact of totalitarian state control is structured by western colonial ontologies of bureaucracy and legislative control of subject people. The project of decolonizing this archive was begun in the 1970s by Indigenous writers negotiating between the archives and their own cultural knowledge to produce major creative works combining both. These works show the passionate, rich storytelling that emerges when indigenous people release the stories captured in the archives and restore them as living cultural heritage.
Imaging in Dementia With Lewy Bodies
Authors: Watson Rosie , Colloby Sean J.
Published: August 2016

Dementia with Lewy bodies (DLB) while common in older age can present a diagnostic challenge to clinicians and is often misdiagnosed as Alzheimer disease (AD). Imaging studies have improved our understanding of the neurobiological changes in DLB during life and how they differ from AD. This has led to significant advances in the development of new techniques, such as dopaminergic imaging, which can aid the clinical diagnosis. Other functional imaging methods also show promise in helping to assess the influence of differing pathologies in DLB, most notably, AD-related and vascular pathology during life. This article will provide an overview of the main imaging findings in DLB.
β-Cell Glucagon-Like Peptide-1 Receptor Contributes to Improved Glucose Tolerance After Vertical Sleeve Gastrectomy
Authors: Garibay Darline , McGavigan Anne K. , Lee Seon A. , Ficorilli James V. , Cox Amy L. , Michael M. Dodson , Sloop Kyle W. , Cummings Bethany P.
Published: August 2016

Vertical sleeve gastrectomy (VSG) produces high rates of type 2 diabetes remission; however, the mechanisms responsible for this remain incompletely defined. Glucagon-like peptide-1 (GLP-1) is a gut hormone that contributes to the maintenance of glucose homeostasis and is elevated after VSG. VSG-induced increases in postprandial GLP-1 secretion have been proposed to contribute to the glucoregulatory benefits of VSG; however, previous work has been equivocal. In order to test the contribution of enhanced β-cell GLP-1 receptor (GLP-1R) signaling we used a β-cell-specific tamoxifen-inducible GLP-1R knockout mouse model. Male β-cell-specific Glp-1rβ-cell+/+ wild type (WT) and Glp-1rβ-cell−/− knockout (KO) littermates were placed on a high-fat diet for 6 weeks and then switched to high-fat diet supplemented with tamoxifen for the rest of the study. Mice underwent sham or VSG surgery after 2 weeks of tamoxifen diet and were fed ad libitum postoperatively. Mice underwent oral glucose tolerance testing at 3 weeks and were euthanized at 6 weeks after surgery. VSG reduced body weight and food intake independent of genotype. However, glucose tolerance was only improved in VSG WT compared with sham WT, whereas VSG KO had impaired glucose tolerance relative to VSG WT. Augmentation of glucose-stimulated insulin secretion during the oral glucose tolerance test was blunted in VSG KO compared with VSG WT. Therefore, our data suggest that enhanced β-cell GLP-1R signaling contributes to improved glucose regulation after VSG by promoting increased glucose-stimulated insulin secretion.
Evolution of frontline treatment of diffuse large B-cell lymphoma: a brief review and recent update
Authors: Hong Jung Yong , Suh Cheolwon , Kim Won Seog
Published: August 2016

Various strategies have been implemented to improve the outcomes of diffuse large B-cell lymphoma (DLBCL). In recent years, remarkable advances have been achieved, based on the discovery of cell-of-origin in DLBCL and on more effective targeted agents. This commentary will summarize recent updates on the evolution of frontline therapies for DLBCL, focusing on the upcoming promising frontline chemotherapy platforms and on activated B-cell subtype DLBCL and double-hit DLBCL.
Nanotechnologies in mechanical engineering
Authors: Шаврин Олег , Shavrin Oleg
Published: August 2016

For the production of structural steel with a nanostructure there are used methods combined into five groups – powder metallurgy, amorphous state crystallization, intensive plastic deformation, surface and volumetric thermo-deformation treatment. The last method is the most effective one for products subjected to cyclic loads and destructed because of fatigue. A limited longevity at loads exceeding fatigue strength increases ten times and more. A thermo-deformation working is carried out at the production of cylindrical spiral springs, cylindrical parts – shafts, axles, mill rollers.
Organizational Direction Formation of the Scientific School of Management Theory
Authors: Райченко  , Raychyenko Alyeksandr
Published: August 2016

Systematizing the basic organizational statements, modern science is the base of structure and interaction in any of the studied area. In turn, submitted by the form, disclosed by the content and classified and determined organization becomes a necessary basis for the construction of any science, and each discipline. General organizational beginning of the formation and development of a system of knowledge, and the action, justify and represent a wide variety of scientific schools, based on mutual understanding of their organization. Formation of the organizational direction of the scientific school of management theory defines the scope of the fundamental notions of order, shape, structure, procedures and methods of construction, design and reflection of all existing and submitted to processes and systems.
Development of the Concept of Knowledge Management
Authors: Смирнова  , Smirnova Valyentina
Published: August 2016

The article considers the scientific contribution of the department “Theory of Management” to the

development of the concept of knowledge management. The department is one of the first in our country

began to study a new area of management, including research, development of the first textbooks, training

programs, the creation of the new training course “knowledge management”, publication of scientific articles

and monographs in the new field of management.
Motivation of Research and Innovation
Authors: Манько  , Manko A. , Лукьяшко  , Lukyashko A. , Сморчкова  , Smorchkova O.
Published: August 2016

One of the key resources of the organization and implementation of professional activity in any field of

knowledge and the field of application is the inner motivation of the parties at its constant upgrading and

improvement. Development and implementation of a format for life organization and conduct of professional

development is fundamentally changing the understanding and attitudes of practicing managers to the place,

role, and value of interaction with scientific and educational groups. This is most evident in establishing

and maintaining their participation in the joint with the faculty of the University departments of scientific

research, conferences and publications on an ongoing basis. First of all, it is typical for graduates of the

graduate school, Ph.D. degree and continuing professional self-improvement, as a part of doctoral studies,

and through independent programs. This generates obvious advantages of joint development of the sphere

of professional management and scientific-educational environment.
On-Stage Playing Space As a Resource of Managers’ Professional Development
Authors: Ростовская  , Rostovskaya A.
Published: August 2016

The article is devoted to the activities of the Laboratory “Workshop stage action in the management” of

the Department of control theory on the formation stage methodology in management education. Appeal

to this modern practice gives the Manager a chance to be holistic in action and to work effectively in a

modern crisis situation. The stage space of the game becomes the site of formation of organizational and

managerial positions in a situation of uncertainty and learning resource is an organic action of one’s own

physicality (body and voice). Stage methodology opens up a different horizon of management education

towards organic management.
Category Theory and Set Theory as Theories about Complementary Types of Universals
Authors: Ellerman David
Published: August 2016

Instead of the half-century old foundational feud between set theory and category theory, this paper argues that they are theories about two different complementary types of universals. The set-theoretic antinomies forced naïve set theory to be reformulated using some iterative notion of a set so that a set would always have higher type or rank than its members. Then the universal u F = {x | F(x)} for a property F(.) could never be self-predicative in the sense of uF ∈ uF . But the mathematical theory of categories, dating from the mid-twentieth century, includes a theory of always-self-predicative universals – which can be seen as forming the “other bookend” to the never-self-predicative universals of set theory. The self-predicative universals of category theory show that the problem in the antinomies was not self-predication per se, but negated self-predication. They also provide a model (in the Platonic Heaven of mathematics) for the self-predicative strand of Plato’s Theory of Forms as well as for the idea of a “concrete universal” in Hegel and similar ideas of paradigmatic exemplars in ordinary thought.
Análise granulométrica de sedimentos arenosos de praias através de imagens digitais. Descrição de um protocolo de mensuração de partículas no software ImageJ - Fiji.
Authors: Guilherme Pablo Damian Borges , Borzone Carlos Alberto , Bueno Maristela de Lima , Lamour Marcelo Renato
Published: August 2016

A análise granulométrica de sedimentos arenosos pode ser realizada através de diferentes técnicas como o peneiramento, a decantação, a difração a laser ou ainda a análise de imagens digitais. A técnica de análise de imagens digital vem sendo difundida por ser considerada a de mais baixo custo, contudo, a maioria dos trabalhos que descrevem o método utilizam programas de computador complexos e pagos. O objetivo do presente trabalho é descrever e avaliar um protocolo metodológico de fácil acesso e baixo custo utilizando para a análise da imagem digital o software ImageJ.  Os resultados obtidos em dez amostras de sedimentos arenosos utilizando o protocolo descrito foram comparados com os resultados de analises granulométricas feitas através do método de peneiramento e de difração a laser. De forma geral, os métodos de análise de imagem e a difração a laser tiveram os resultados similares. Estes resultados concordaram em 60% das classificações textuais (considerando os parâmetros estatísticos de média e seleção). Nas classificações dispares, os valores absolutos estiveram bem próximos dos limites dessas classificações, com diferenças entre métodos de apenas 0,1Ø (e.g. #45). Desta forma, a análise de imagem digital utilizando o programa livre ImageJ mostra-se uma ferramenta de ótima acurácia e robustez, além de ser de baixo custo e fácil acesso.
Application of Bethesda terminology to categorize buccal epithelial smears among petroleum station workers in Taif city, KSA
Authors: Hassan Elesawy Basem , Abd El hafez Amal , Shawky Mohamed Abdelaty , Mansour A. Salih Magdi
Published: August 2016

Background and Objectives: Exposure to Petroleum products has a well-established mutagenicity and carcinogenicity of some compo-nents such as benzene. Buccal mucosal cells are capable of metabolizing the carcinogenic compounds to reactive chemicals. We investigated the buccal epithelial cell cytological changes resulting from the occupational exposure to Petroleum derivatives such as benzene.Methods: Samples were obtained from 70 Petrol station workers in Taif city-KSA, examined using the Papanicolaou stained smears and categorized based on Bethesda Terminology System. Statistical analysis was carried out with the SPSS.Results: About 38.6% of petrol station workers exhibited buccal cytological changes ranging from atypical squamous cells of undetermined significance (ASC-US) to high-grade squamous intraepithelial lesions (HSIL). Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) was the most frequent cytological abnormality. Buccal smears with abnormal cytological findings dominated among smokers in contrast to non-smokers with a statistically significant difference (P = 0.026). No significant associations were detected between the category of buccal cytological changes and the duration of work or the participant's age.Conclusion: Bethesda Terminology System can be efficiently applied to buccal smears. Petrol products induce precancerous epithelial changes in buccal epithelial cells indicating a potential health risk for Petrol station workers, thus annual checkup for those workers should be set as primary prevention of occupational-related cancer. Cigarette smoke is a co-factor that exacerbates the effects of Petrol derivatives.
Der lange Widerstand gegen eine offizielle Heiligenverehrung des Maximos Homologetes († 662) im byzantinischen Reich
Authors: Ohme Heinz
Published: August 2016

This article addresses the question as to why Maximus the Confessor was first recognized as an official martyr and saint in the imperial Byzantine Church only in the tenth century, although his theology had been accepted by the Sixth Ecumenical Council and his followers began to practice and propagate his cult shortly after his death in 662. The argument begins with a brief description of Maximus’ early veneration and then examines the Sixth Ecumenical Council’s failure to rehabilitate him by detailing the reasons why this was impossible in 681 and also thereafter. Clearly, in the seventh and eighth centuries the cult of Maximus had its centre outside the empire in parts of Palestinian monasticism. During the iconoclastic era, as in the seventh century, Maximus’ name stood once again for opposition to imperial religious policy, for he was held up by those venerating icons as the witness of Tradition to their use. Although during this time iconophile monastic circles in the capital probably fostered his cult as well, his veneration continued to find no official recognition in the ninth century because of on-going division within the church of Constantinople. Only after a great distance in time to the events of the seventh century could official recognition in Byzantium come to Maximus, since the conflicts of that earlier era were no longer relevant. In this context, the ‘Holy Confessor Maximus’ underwent a process of acceptance by the Byzantines who anchored his biography in Constantinople. As a result, the actual circumstances of the monothelete controversy have ultimately been obscured.
John IX Patriarch of Jerusalem in exile
Authors: Spingou Foteini
Published: August 2016

A series of seven epigrams from the Anthologia Marciana (MS Marc. gr. 524) sheds light on the life of John IX Merkouropoulos, patriarch of Jerusalem in exile (1157-before 1166). The evidence that comes to light reveals traces of a monastic network connecting Jerusalem with Constantinople. According to the epigrams, John became a monk at Mar Saba - something further evinced by the double vita of St John of Damascus and Kosmas of Maiouma that he composed [BHG 395]. After staying at the Koutsovendis monastery, he travelled to Constantinople, where Manuel I appointed him on the patriarchal see and also made him abbot of the monastery of St Diomedes/New Zion in Constantinople. Shortly before or after John’s departure from life, his disciple, the monk Clement, attempted to manifest that his spiritual father was a holy man. Thus, Clement had John’s portrait placed next to that of St James, the brother of God. John’s complex relationship with the Syropalestinian monastic tradition make his life and the survival of his memory an exceprional case study for understanduing the phenomenon of Holy Men in twelfth-century Constantinople.
Pharmacokinetics of ceftriaxone in patients undergoing continuous renal replacement therapy
Authors: Goto Koji , Sato Yuhki , Yasuda Norihisa , Hidaka Seigo , Suzuki Yosuke , Tanaka Ryota , Kaneko Tetsuya , Nonoshita Ko , Itoh Hiroki
Published: August 2016

Background:

The duration of time for which the serum levels exceed the minimum inhibitory concentration (MIC) is an important pharmacokinetics (PK)/pharmacodynamics (PD) parameter correlating with efficacy for the antibiotic, ceftriaxone (CTRX). However, no reports exist regarding the PK or PD in patients undergoing continuous renal replacement therapy (CRRT). The purpose of this study was to examine the PK and safety of CTRX in patients undergoing CRRT in order to establish safer and more effective regimens.

Methods:

CTRX (1 g once a day) was intravenously administered four or more times to nine patients undergoing CRRT. Blood was collected after administration to measure CTRX concentrations in serum and the filtration fraction of CRRT by high-performance liquid chromatography. In addition to calculating PK parameters from serum CTRX, we (a) estimated by simulation CTRX concentrations when the dose interval was extended to once every 2 or 3 days, (b) calculated CTRX clearance via CRRT from CTRX concentrations in the filtration fraction, and (c) assessed the safety of CTRX use.

Results:

Total body clearance and the half-life of CTRX were 7.46 mL/min (mean) and 26.5 h, respectively, in patients undergoing CRRT. CTRX was found in the filtration fraction, and the estimated clearance by CRRT was about 70% of total body clearance. Simulations revealed that even when the dose interval is increased to 2 or 3 days, CTRX would retain its efficacy.

Conclusions:

Our findings suggest that, depending on the condition of patients undergoing CRRT, CTRX could be used safely against pathogens with a CTRX MIC ≤2 µg/mL, even when extending the dose interval.
Mining Spatial Association Rules to Automatic Grouping of Spatial Data Objects Using Multiple Kernel-Based Probabilistic Clustering
Authors: Jayababu Y. , Varma G.P.S. , Govardhan A.
Published: August 2016

With the extensive application of spatial databases to various fields ranging from remote sensing to geographical information systems, computer cartography, environmental assessment, and planning, discovery of interesting and hidden knowledge in the spatial databases is a considerable chore for classifying and using the spatial data and knowledge bases. The literature presents different spatial data mining methods to mine knowledge from spatial databases. In this paper, spatial association rules are mined to automatic grouping of spatial data objects using a candidate generation process with three constraint measures, such as support, confidence, and lift. Then, the proposed multiple kernel-based probabilistic clustering is applied to the associate vector to further group the spatial data objects. Here, membership probability based on probabilistic distance is used with multiple kernels, where exponential and tangential kernel functions are utilized. The performance of the proposed method is analyzed with three data sets of three different geometry types using the number of rules and clustering accuracy. From the experimentation, the results proved that the proposed multi-kernel probabilistic clustering algorithm achieved better accuracy as compared with the existing probabilistic clustering.
Development of an Artificial Neural Network Based Model for Mimicking Combustion Tube Experiments for Heavy Oil Recovery
Authors: Y. Bansal  , T. Ertekin  , M. Al-Wadhahi
Published: August 2016

Over the years, technologies for improved recovery of heavy oil have become an important part of the research efforts to meet the increasing demand for oil. Various methods are being developed for heavy oil recovery and among them in-situ combustion process has shown a good degree of potential in laboratory and pilot tests conducted in field. The in-situ combustion process needs to be studied further extensively because of the high degree of operational complexities involved in the process. Extensive laboratory studies have been conducted; however, a typical in-situ combustion tube experiment in the laboratory can be very costly in terms of its time, personnel and equipment requirements.This work aims at reducing the number of laboratory experiments by developing an artificial neural network (ANN) that has the ability of emulating in-situ combustion tube experiments. An intelligent database was generated using commercial software to train the network within the parametric ranges adapted from previous experimental work. The ANN model was used to predict the cumulative production of oil, water and gas, peak temperature attained, location and velocity of the combustion front in the numerical combustion experiments mimicking the physical experiments. The proposed ANN model can be used to focus towards designing the experimental program within a rather small range of parameter variations resulting in more economical and focused analysis. Therefore, our methodology provides a unique and novel approach to understand in-situ combustion experiment.
Predictors and patterns of problematic Internet game use using a decision tree model
Authors: Rho Mi Jung , Jeong Jo-Eun , Chun Ji-Won , Cho Hyun , Jung Dong Jin , Choi In Young , Kim Dai-Jin
Published: August 2016

Background and aims

Problematic Internet game use is an important social issue that increases social expenditures for both individuals and nations. This study identified predictors and patterns of problematic Internet game use.

Methods

Data were collected from online surveys between November 26 and December 26, 2014. We identified 3,881 Internet game users from a total of 5,003 respondents. A total of 511 participants were assigned to the problematic Internet game user group according to the Diagnostic and Statistical Manual of Mental Disorders Internet gaming disorder criteria. From the remaining 3,370 participants, we used propensity score matching to develop a normal comparison group of 511 participants. In all, 1,022 participants were analyzed using the chi-square automatic interaction detector (CHAID) algorithm.

Results

According to the CHAID algorithm, six important predictors were found: gaming costs (50%), average weekday gaming time (23%), offline Internet gaming community meeting attendance (13%), average weekend and holiday gaming time (7%), marital status (4%), and self-perceptions of addiction to Internet game use (3%). In addition, three patterns out of six classification rules were explored: cost-consuming, socializing, and solitary gamers.

Conclusion

This study provides direction for future work on the screening of problematic Internet game use in adults.
Crystal Growth and Optical Properties of AgGaS2 and AgGaSe2
Authors: Catella Gary C. , Burlage David
Published: August 2016

Silver gallium sulfide (AgGaS2), silver gallium selenide (AgGaSe2), and silver gallium indium selenide (AgGaxIn(1 − x)Se2) are unique nonlinear crystals suitable for a wide range of three-wave mixing applications. They combine strong nonlinear coupling with phase matching across a wide (0.5 − 12.5 μm) transmission range. These properties provide the basis for CO2 laser harmonic-generator (HG), visible (VIS), and near-infrared (NIR) pumped opticalparametric-oscillator (OPO) and sumand difference-frequency-generator (SFG/DFG) systems for producing tunable laser radiation from approximately 0.65 to 12 μm. A wide range of pump lasers is now available, including diode lasers capable of direct pumping of AgGaS2 and efficient diode-pumped lasers for pumping any of these crystals. Significant progress in material characteristics and nonlinear optical (NLO) performance has been accomplished. Bulk absorption for production-quality AgGaS2 is ~0.01 − 0.02 cm across the 0.8−9-μm region. Exceptional crystals of AgGaS2 have absorption <0.0005 cm−1 at 1.064 μm, and even at 0.633 μm, absorption is ~0.015 cm−1. Figure 1 illustrates the late 1980s vintage and present transmission of AgGaS2. For AgGaSe2, absorption for production material ranges from 0.010 cm to 0.018 cm−1 from 1 μm to 11 μm. Certain crystals can have 0.007−0.008 cm−1 absorption at 10.6 μm. The NIR transmission curves for AgGaSe2 and AgGaxIn(1 − x)Se2 appear in Figure 2. This combination of optical properties, along with their good physical characteristics, make these two crystals versatile for NLO applications spanning the VIS to the infrared (ir).