bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of nasopharyngeal microbiota role in development of chronic lymphoproliferative syndrome of ent organs in young children
Authors:   Saint Petersburg Institute of Ear, Throat, Nose and Speech, Saint Petersburg, 190013, Russia, Drozdova M. V. , Larionova S. N. ,   Saint Petersburg Institute of Ear, Throat, Nose and Speech, Saint Petersburg, 190013, Russia, Tyrnova E. V. ,   Saint Petersburg Institute of Ear, Throat, Nose and Speech, Saint Petersburg, 190013, Russia
Published: January 2023

To assess the nasopharyngeal microbiota role in the development of chronic lymphoproliferative syndrome of ENT organs in young children, 40 children aged 2–3 years were examined. Cytological and cultural bacteriological studies of nasopharyngeal smears were carried out. Serological and molecular genetic analyzes of markers of herpesvirus infections (Epstein–Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus type 6 (HHV-6)) in the blood, polymerase chain reaction (PCR), and immunofluorescence reaction (RIF) were performed with generic antiherpetic sera of the same name in scrapings of the pharyngeal tonsil. In the rhinocytogram, 57,14% of children had poor gram-positive cocci, characteristic of the normal state of the mucosa. In nasopharyngeal smears, the growth of microorganisms of opportunistic and saprophytic microbiota was not detected in a diagnostically significant amount in 19,44% of children; isolated growth of normal aerobic and/or facultative anaerobic microbiota was observed with the same frequency. Opportunistic microbiota was detected in 61,11% of cases, including associations of saprophytic microbiota and opportunistic microorganisms were detected in 27,78% of children. Most often, Staphylococcus aureus 54,55% was detected in children; known respiratory pathogens were found less frequently: Streptococcus pneumoniae 31,82%, Haemophilus influenzae 13,64%, Moraxella catarrhalis 13,64%. In the majority of patients, 77,27%, one type of pathobiont was identified. 100% infection with herpesvirus infections was established, including EBV 66,67%, CMV 56,41%, HHV-6 61,54%. Mixed infections dominated 69,23%, EBV infection prevailed among mono infections. The active stage of herpesvirus infection was established in 56,41% of children, of which 77,27% were mono infections, and 22,73% were mixed infections, among which 80% were EBV + HHV-6. Most frequently, there were detected the signs of active EBV infection 46,15%, HHV-6 reactivation was detected in 20,51% of cases, active CMV persistence was much less common 7,69%. The active stage of herpesvirus infections was confirmed by the study of brush-smears of the nasopharyngeal mucosa with immunofluorescence test and PCR. In general, the traditional semi-quantitative studies of cultures of bacterial colonies from samples of the pharyngeal tonsil biotope did not reveal a unified causative agent (pathogen) of chronic lymphoproliferative syndrome of ENT organs in young children.
Assessment of prevalence of chronic rhinosinusitis
Authors:   Saint Petersburg Research Institute of Ear, Nose, Throat, and Speech,  Saint Petersburg, 190013, Russia, Krivopalov A. A. , Moroz N. V. ,   Mechnikov North-Western State Medical University, Saint Petersburg, 191015, Russia, Artyushkin S. A. ,   Mechnikov North-Western State Medical University, Saint Petersburg, 191015, Russia, Shamkina P. A. ,   Saint Petersburg Research Institute of Ear, Nose, Throat, and Speech,  Saint Petersburg, 190013, Russia, Zakharova G. P. ,   Saint Petersburg Research Institute of Ear, Nose, Throat, and Speech,  Saint Petersburg, 190013, Russia
Published: January 2023

Objective. To summarize data on the epidemiology of chronic rhinosinusitis (CRS) with an emphasis on prevalence and risk factors. Materials and methods. The analysis of English- and Russian-language publications using databases: PubMed, Russian Science Citation Index, Springer, Scopus, Scientific Research, Crossref, eLibrary. The search depth is 10 years (2012–2022). The paper presents data from original epidemiological studies, reflects differences in estimates of the prevalence of the disease depending on the research method, sample characteristics, predisposing environmental conditions. Results. The use of symptomatology and objective diagnostic criteria makes it possible to identify the prevalence of CRS in more than 10% of the population. When using both methods, the true prevalence of CRS is about 5%. Differences in the prevalence of CRS associated with concomitant living conditions and the general condition of patients indicate the presence of risk factors, such as modifiable: smoking, air pollution, socioeconomic, comorbid diseases, as well as unmodified: hereditary, demographic (gender, race, age). Conclusion. During the follow-up period, along with the introduction of new treatment methods, the prevalence of CRS in Russia and the world has been maintained, which requires improving the organizational and methodological approach to the prevention, diagnosis, and treatment of this disease. The expansion of data on the epidemiological patterns of CRS makes it possible to optimally identify the disease process for each patient, thereby contributing to an increase in the effectiveness of treatment at the general social level.
El nuevo reporte de sostenibilidad corporativa en el mercado de valores: Apuntes en torno a la cadena de producción y el consumo responsable
Authors: Arce Rodríguez Mario Marcelo
Published: January 2023

En el presente artículo, el autor pone en tela de juicio al nuevo reporte de sostenibilidad corporativa, emitido mediante Resolución de Superintendente 018-2020-SMV/02. En esta línea, trata el significado de sostenibilidad corporativa, o cómo debería ser entendida, en el mercado actual. Resalta, asimismo, la importancia del principio de transparencia de mercado respecto a la sostenibilidad corporativa de cara a la información necesaria con la que deben contar los inversionistas.Enfocándose en la cadena de producción y el consumo responsable, el autor evalúa las preguntas del formulario sobre sostenibilidad corporativa emitido por la Superintendencia del Mercado de Valores a través de los estándares fijados por los indicadores Ethos–IARSE, así como por Global Reporting Initiative. Todo ello para concluir que, a pesar que se ha dado un gran paso relativo a la información brindada, aún quedan muchos aspectos por especificar para llegar a los estándares actuales sobre sostenibilidad corporativa.
Pensar y sentir de estudiantes de derecho en su contacto con el mundo profesional
Authors: Del Mastro Puccio Fernando
Published: January 2023

En el Perú, quienes estudian la carrera de derecho deben completar un periodo de prácticas preprofesionales. Pese a la relevancia que tienen estas experiencias como primer contacto con la realidad del ejercicio profesional, no se ha investigado cuál es su impacto en la formación de los estudiantes. En este artículo, a partir de un marco teórico centrado en Hannah Arendt y del análisis narrativo de relatos de estudiantes, se busca comprender cómo operan los pensamientos congelados en sus experiencias como practicantes preprofesionales.A partir del análisis, se han identificado los siguientes pensamientos congelados: (i) trabajar en exceso es necesario para aprender, (ii) el maltrato es válido si les ocurre a todos y (iii) el propio rol consiste en cumplir los encargos sin pensar ni cuestionar. Aunque estos pensamientos son transmitidos a los estudiantes en situaciones de incumplimiento legal, maltrato y comisión de faltas éticas, suelen actuar conforme a lo esperado sin decir ni hacer algo. Predomina el miedo a no ser valorados y se deja de lado cualquier proceso de reflexión donde puedan cuestionar lo que les indican. Hay, sin embargo, casos donde los estudiantes dudan de si tales pensamientos son correctos, pero el conflicto interno queda sin resolver.La relevancia de este trabajo radica en mostrar parte de lo que acontece en un ámbito formativo que tiene gran impacto en el aprendizaje, pero que ha sido desatendido. Particularmente, muestra modos en los que factores anímicos, como el deseo de ser reconocido y la duda respecto a la propia valía, funcionan como barreras en los procesos de pensamiento y acción. Finalmente, a nivel de reflexión pedagógica, se presenta a la pedagogía socrática como aproximación que puede tener buenos resultados a nivel de la formación ética de estudiantes que viven situaciones como las analizadas.
Aproximaciones y comentarios a las reorganizaciones societarias transfronterizas: La fusión y la redomiciliación
Authors: Véliz Ortíz Samuel Jair , D’Medina Valdez Paula
Published: January 2023

El presente trabajo tiene como objetivo analizar las denominadas reorganizaciones societarias transfronterizas, que tienen la particularidad de involucrar a sociedades constituidas y existentes en distintos países, centrándose en las fusiones y la redomiciliación de sociedades.Para ello, los autores analizan los conceptos jurídicos de nacionalidad y domicilio de las personas jurídicas, fusión y redomiciliación de sociedades, las consideraciones que conllevan a la implementación de este tipo de operaciones y, finalmente, si es posible ejecutar una fusión transfronteriza y una redomiciliación de una sociedad peruana al extranjero según la normativa vigente.
El género en la concepción y aplicación de la justicia penal
Authors: Miró Quesada Gayoso Josefina
Published: January 2023

El artículo analiza, a partir de una perspectiva jurídico penal y criminológica, el rol del género en la concepción y aplicación del sistema de justicia penal, a lo largo de sus distintas etapas. En esa línea, parte de los cuestionamientos a la aparente neutralidad que ofrecen las categorías jurídico-penales, construidas e interpretadas desde un lente androcéntrico que excluye y desvalora las experiencias, intereses y valores femeninos. A través de una revisión crítica de la literatura que estudia la interacción del poder punitivo y el poder patriarcal, se expone y analizan los efectos empíricos, a nivel comparado de leyes penales, sustantivas y procesales, pensadas y aplicadas sin perspectiva de género.Se sostiene, así, la necesidad de operadores de la justicia de aplicar el derecho penal con perspectiva de género, mientras se idean fórmulas de justicia que descentralicen el paradigma punitivo tradicional.
Bid rigging o concertación en licitaciones: ¿Qué, cuándo y cómo se produce un hard core cartel bajo esta modalidad?
Authors: Chang Tokushima Juan Santiago , Drago Alfaro Mario Fernando
Published: January 2023

En los últimos años, el Instituto Nacional de Defensa de la Competencia y de la Protección de la Propiedad Intelectual ha enfocado sus esfuerzos en la persecución y sanción de prácticas horizontales, iniciando un paso sustancial a favor de mejorar la libre competencia de mercado.En este trabajo se analizan las razones por las cuales la legislación de libre competencia nacional considera a las concertaciones en licitaciones públicas como conductas per se ilegales, y cómo el Instituto Nacional de Defensa de la Competencia y de la Protección de la Propiedad Intelectual ha perseguido y sancionado tales prácticas. Los autores consideran que la tipificación expresa de las concertaciones en licitaciones públicas como prácticas prohibidas de carácter absoluto responde a su impacto social, antes que a un razonamiento económico que la diferencia de otras conductas ilegales per se.
Effect of Feeding Gram Straw-based Complete Feed Pellets on the Performance, Nutrient Utilization and Rumen Fermentation of Goats
Authors: Patil P.V. , Gendley M.K. , Dubey Meenu , Dhok A.P. , Gade N.E. , Khune V.N.
Published: January 2023

Background: Using crop residues in goat rations is essential to prevent the shortage of fodder for goats in rural areas. To overcome the problems of low acceptability, digestibility, low nutrient contents of crop residues, preparation of crop residue based complete feed pellets is the best way. The aim of this study is to evaluate the effect of feeding gram straw-based complete feed pellets on the growth performance, nutrient utilization and rumen fermentation of goats. Methods: The goats in groups I and II were fed ad lib supernapier hay + 300 gm concentrate daily and ad libitum gram straw-based complete feed pellets with roughage to concentrate ratio of 70:30, respectively. The growth performance, nutrient utilization and rumen fermentation study, along with an estimation of hematological and blood biochemical parameters, were carried out in this experiment. Result: Significantly better growth performance, nutrient utilization, rumen fermentation and low cost of production was found in goats of group II (fed gram straw-based complete feed pellets) with the non-significant difference in body condition score, rumen motility and hematological parameters in goats of group II than group I. The blood glucose values found significantly more in group II as compared to group I. Feeding gram straw-based complete feed pellets improved performance, nutrient utilization and proved to be economical.
Развој писмености и културе читања у Јапану
Authors: Васић Данијела
Published: January 2023

Јапанци за себе кажу да су „нација читалаца“. То и није нетачно ако се погледа историја читања у Јапану, која сеже до 5. века, када је кинеско писмо стигло у ову земљу. Јапанци су то писмо постепено прилагођавали свом језику, што је довело до правог процвата књижевности. И штампа је у Јапан стигла из Кине, а временом се од будистичких текстова прешло на штампање књига најразличитијих жанрова. Путујући трговци и бројне књижаре у којима су се књиге и изнајмљивале, настојали су да утоле читалачку глад свих друштвених сталежа. На таквим темељима почива и издавачка, али и развијена библиотечка делатност савременог друштва. Упркос чињеници да напредак информационих технологија удаљава људе од књига, чини се да јапанске библиотеке ипак одолевају овим притисцима. Развијена читалачка култура очитује се у броју издатих књига, али и у постојаном расту броја библиотека, како јавних, тако и специјалних, као и библиотека у оквирима образовног система у Јапану.
Пракса куповања књига међу студентима Универзитета у Београду
Authors: Стошић Анђела
Published: January 2023

У раду су представљени резултати квантитативне студије која је истраживала понашање студената Београдског универзитета у вези са куповином књига које не спадају у домен наставне литературе. У електронском анкетирању спроведеном у јулу 2020. године учествовао је 471 испитаник чији су се одговори односили на понашање у протеклих годину дана. Резултати показују да је чак 84,3% (397) академаца купило барем једну књигу током наведеног периода. Најчешће се књиге набављају у неком од ланаца књижара (332), мада није занемарљив број оних који их наручују са веб-сајтова књижара (157) или на неким другим веб-страницама (86). Одређен број студената купује и електронске књиге (33). Испитаници се најчешће одлучују за класике иако су заинтересовани и за трилере, драме, криминалистичке романе, као и за едукативне садржаје, филозофију и психологију. Половина студената који купују књиге позајмљује штиво за читање из библиотеке. Од оних који књиге не купују, 23% (17) користи услуге библиотека, а 27% (20) њих чита књиге у електронском облику које проналази на интернету.
Does national corruption encourage earnings management? A comparison of countries on the European and American continents
Authors: Sousa Allison Manoel de , Sousa Rayane Camila da Silva , Orsato Renata , Colauto Romualdo Douglas
Published: January 2023

We analyzed the effect of national corruption perceived by the population on earnings management. Our sample consisted of 3,239 companies from 38 countries located in four geopolitical regions of the American and European continents between 2012-2019, analyzed using regression with panel data. We found that increasing levels of perceived corruption implies an increase in earnings management practices. Behavior that does not occur in the same way when considering the different geopolitical regions, because it occurs only in Latin American, North America and the Caribbean, but is non-existent in the other regions. We provide evidence that the perception of national corruption is a trigger for managers to change accounting choices.
Persepsi Mahasiswa Islam Penghafal Qur’an Terhadap Jilboobs Sebagai Tren Baru
Authors: Paulina Melisa , Mutiah Diana
Published: January 2023

Jilboobs is a term used to describe women who wear headscarves but show body curves, or in other words Jilboobs is a tight female hijab style. This study aims to look at the student perspectives of those who memorize the Qur'an towards Jilboobs as a new trend. Qualitative method with purposive sampling technique. This study used 6 subjects with certain criteria, namely Islamic students, memorizing the Qur'an, and participating in Islamic studies. Based on the results of the study, it showed that Jilboobs was not in accordance with the proper Islamic studies. For all subjects, even though Jilboobs are considered a new trend, it does not make Islamic students who memorize the Qur'an follow trends because for them the benefits or purpose of wearing the hijab is to cover the genitals (the whole body). For the six subjects, not following the Jilboobs trend did not make him feel out of date, as a memorizer of the Qur'an, it was appropriate to have the morality of the Qur'an by implementing Islamic law and avoiding harm in Islam so that it was an obligation to wear the hijab according to Islamic law
Upaya Guru dalam Penanaman Nilai-Nilai Karakter Religius Anak Kelas IV Sekolah Dasar
Authors: Najiha Riana Lutfi , Maryamah Maryamah , Husni Miftahul , Nurlaeli Nurlaeli
Published: January 2023

Penelitian ini dilatar belakangi oleh kenyataan lapangan bahwa dalam pelaksanaanpembelajaran karakter religius terdapat upaya guru dalam penanaman nilai-nilai karakter religius pada anak kelas IV SDN 1 Trans Batumarta VII. Tujuan dari peneliian ini yaitu(1) mengetahui apa saja upaya yang dilakukan guru dalam menumbuhkan karakter religius pada peserta didik, (2) untuk mengetahui nilai- nilai apa saja yang ditanamkan pada penanaman karakter religius, (3) mengetahui faktor pendukung dan penghambat apa saja yang mendukung adanya penanaman karakter religius pada peserta didik di SDN 1 Trans Batumarta VII. Adapun jenis penelitian yang digunakan adalah penelitian kualitatif dengan menggunakan pendekatan deskripstif kualiatif.

Hasil dari penelitian yaitu dalam penanaman karakter religius di SDN 1 Trans Batumarta VII yaitu terdapat upaya guru dalam penanamannya seperti upaya penanaman shalat dhuha yang dilaksanakan tempat Mushola Sekolah serta di Imami oleh Bapak K. membaca surah- surah pendek yang dibaca ketika selesai berdoa belajar yang dipimpin oleh guru yang mengajar pada jamnya dan membaca doa sebelum belajar yang dipimpin oleh guru yang mengajar . Dari nilai-nilai yang digunakan dalam penanaman karakter religius siswa adalah seperti nilai aqidah, nilai akhlak, nilai disipilin, nilai tanggung jawab, dan kejujuran. Faktor pendukung yaitu kerjasama antara kerjasama guru dan wali murid, adapun kendala yang dihadapi adalah kesadaran dari peserta didik, serta dari orang tua yang kurang membimbing anak dalam penanaman karakter religius anak, dan penanaman tidak berjalan dengan normal karena proses belajar mengajar yang terkendala (pandemi) dan faktor lain seperti faktor eksternal (tempraman,

gangguan jiwa, konflik dan keraguan, jauh dari Tuhan), dan faktor internal

(lingkungan keluarga, lingkungan sekolah, sarana dan prasarana)
Academics’ perspective on out-of-school learning environments
Authors: ASLAN Ayşegül , BATMAN Demet , DURUKAN Ümmü Gülsüm
Published: January 2023

This study aims to ascertain academicians' opinions about out-of-school learning, awareness of it, and competency to plan learning activities in such situations for the purpose of teaching in out-of-school learning environments (OSLEs). The research group of this study, which was conducted as a case study, consists of 56 academics in the physics, chemistry, biology, and science education programs of education faculties in Türkiye. The Out-of-School Learning Environments Regulation Scale and a form containing four questions were used to data collection. The results from the scale, the average score was calculated as 4.41 for academics with experience in teaching OSLEs and 3.82 for academics without such experience. The qualitative results indicate that academics mostly prefer to focus on environmental education, astronomy, living things and life, and recycling issues through out-of-school learning activities and use different types of OSLEs such as science center, recycling facility and observatory. To conclude, despite the academics' high level of competency in performing out-of-school learning activities, it is evident that they underutilize these activities in their teaching.
Aplicação de experimento fatorial como método para a definição de zonas bioclimáticas a partir do conforto térmico
Authors: Ferreira Camila Carvalho , Carlo Joyce Correna
Published: January 2023

O zoneamento bioclimático apresenta-se como importante ferramenta para fornecer subsídios para a estruturação de normativa de desempenho térmico e de códigos de eficiência energética de edificações. No entanto, uma metodologia consistente para o desenvolvimento de propostas de zoneamentos é ainda tema de ampla discussão. O objetivo deste artigo é avaliar a aplicabilidade do experimento fatorial como método para caracterização de zonas bioclimáticas. Para tal, empregou-se o experimento fatorial para a análise das variáveis de influência no desempenho térmico de edificações residenciais ventiladas naturalmente em diferentes climas brasileiros. Foram realizadas simulações de desempenho térmico a partir da fatorial e as cidades analisadas foram agrupadas de acordo com a performance quanto ao conforto térmico e com as variáveis de influência. De forma geral, as principais variáveis de influência no conforto térmico das edificações foram a absortância solar da envoltória, a transmitância térmica das coberturas e a ventilação. Para climas mais amenos a transmitância térmica das paredes também apresentou influência, enquanto a capacidade térmica das paredes apresentou influência para os climas de transição. Dentre as localidades amostradas, pode-se reconhecer quatro padrões de comportamento quanto ao conforto térmico e quanto às variáveis de influência, possibilitando o agrupamento das cidades. Identificou-se quatro zonas bioclimáticas, subdivididas de acordo com as necessidades de ventilação específicas locais. A originalidade deste trabalho está na proposta de uma caracterização de zonas bioclimáticas fundamentada em um modelo de conforto adaptativo, na inclusão de mais de um modelo de edificações multifamiliares na análise e na utilização do experimento fatorial.
La tragédie humaine et le drame féminin
Authors: Lescourret Marie-Anne
Published: January 2023

Il me semblait intéressant de réunir ces deux artistes contemporains, l’un Français, Lionel Guibout, l’autre Chinois, He Canbo, dont les démarches se rejoignent dans une certaine expression de l’humanité, pour laquelle chacun a trouvé une modalité plastique singulière. C’est là une constante de l’art de He Canbo, inquiet des évolutions de la société, ainsi que de la destinée de l’homme dans le monde, dans le cosmos, ou même tout simplement dans la ville, ou le cycle quotidien. De là la multiplication des situations dans lesquelles il place les humains interchangeables figurés par ses « omégas ». Lionel Guibout s’est d’abord intéressé à l’humanité conservée, monumentale et mythique, dans les sculptures grecques, avant de la chercher dans la vie de la nature, associant l’écorce des arbres, les croûtes de la terre, et la peau des humains. Et c’est par l’entremise de cette peau vivante, souffrante, « écorcée », qu’il traduit encore sa préoccupation de l’offense actuelle faite aux femmes.
The quality of university administration between the decision and the future at work
Authors: الكميم د. محمد محي الدين
Published: January 2023

The study aimed to know the extent to which the university of Sheba administration applies the principles of quality in higher education and the viewpoint of professors on the necessity of selecting for higher administrative positions, and the extent to which the quality of university administration contributes to achieving job stability and decision-making. A questionnaire was distributed for the study to a sample of 39 professors at the University of Sheba Province. The study concluded that the university administration seeks to apply the principles and culture of administrative quality, but it is ineffective and insufficient to achieve the best performance of the university professor, It is also necessary to select for senior management positions according to some personal characteristics, values, and some behavioural skills, such as social competence and leadership behaviour, therefore, visions and preferences differed among professors regarding the importance of stability for some high quality positions.
“Aqui reina o respeito, mas…”: as dimensões pedagógicas do aplicativo Grindr em Campo Grande, MS
Authors: Montecio Gabriela Alencar , Rosa Marcelo Victor da
Published: January 2023

O estudo tem por objetivo analisar as discursividades produzidas pelos(as) usuários(as) do aplicativo Grindr, este usado principalmente por homens em busca de relações, sobretudo sexuais, com homens. A pesquisa foi realizada no período de setembro de 2021 a julho de 2022, em Campo Grande, MS. Assim, apoiando-se nos amplos processos pedagógicos provenientes dos discursos circulantes no Grindr, vemos este como sendo um artefato abundante em conteúdo. A intenção, a partir desse conhecimento, foi de estar no aplicativo para compreender o que se aprende, ensina, descobre e transforma ao se entender as dinâmicas que medeiam as discursividades no Grindr enquanto estratégias que se disseminam por meio dos discursos. Para tal, criamos uma conta gratuita para obtenção de prints, e, a partir desses, foi possível observar três dimensões pedagógicas presentes nas discursividades. Dessas, a primeira faz menção às dinâmicas do cancelamento, que perpassa todas as dimensões; a segunda revela a masculinidade hegemônica marcada pela discrição, pelo sigilo e pelo homem com jeito de homem que converge à norma. Por fim, a terceira dimensão alcança as rupturas presentes nas discursividades contra-hegemônicas, dissidentes à norma.
A alma feminina em santinhos católicos
Authors: Carvalho Rosângela Tenório de
Published: January 2023

O artigo discute os santinhos como elemento de reiteração de condutas na atribuição de uma alma feminina. A análise utiliza elementos teórico-analíticos de estudos de gênero e performatividade, arqueogenealógicos, de estudos culturais e de estudos sobre imagem e comunicação. Aborda-se um corpus de análise constituído de santinhos da iconografia católica, interpolando-o com enunciados de outros materiais culturais para dar visibilidade à rede interdiscursiva e a aspectos performativos que marcam a posição de um sujeito com uma alma feminina.
O currículo das ruas: instâncias efêmeras, móveis e de luta pelo direito à cidade
Authors: Carneiro Glaucia , Paraíso Marlucy Alves
Published: January 2023

O artigo traz resultados de uma pesquisa realizada para a tese de doutorado que investigou o que chamamos de Currículo das Errâncias com a Pedagogia da Hesitação.  A partir de procedimentos retirados da Filosofia da Diferença, de Gilles Deleuze, da noção de Corpos em Aliança, de Judith Butler, este artigo detalha alguns signos desencadeados pelo currículo clandestino da rua, mostrando como funcionam e quais os encontros/saberes que provocam.  O argumento desenvolvido é que aprender da/na rua exige, acima de tudo, estar sensível às variações materiais que ocorrem em nosso imaginário. O artigo mostra que muito se aprende com o corpo em trânsito pelas ruas quando o corpo consegue se abrir aos signos políticos, desencadeados pelos artivismos urbanos.
Escola, imaginários pedagógicos e infâncias latino-americanas em Chaves
Authors: Friedrich Daniel , Arata Nicolás
Published: January 2023

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Phytochemical Screening and Toxicity Test of Various Extracts from Microalgae Dunaliella salina
Authors: Sijabat Yosi Yananda , Wilis Ari Setyati  , Retno Hartati
Published: January 2023

Highlight Research

Extract N-hexane of salina contains alkaloids, steroids, triterpenoids, and phenols
Extract Ethyl Acetate of salina contains alkaloids, steroids, triterpenoids, phenols, flavonoid, and saponins
Extract Methanol of salina contains alkaloids, steroids, triterpenoids, phenols, flavonoid, and saponins
24- hours LC50 value of the n-hexane extract salina was 276 ppm, the ethyl acetate extract was 673 ppm and the methanol extract was 811 ppm. All of the three extracts were included in toxic category

 
Abstract
Microalgae are single celled microorganisms as the primary producers in the water food cycle. Microalgae bioactive compounds was estimated to be 10 times more diverse than compounds produced by land plants. Microalgae use nutrients more efficiently to grow, metabolize, and produce chemical compounds. Dunaliella salina is a type of chlorophyte microalgae with a lot of potential to be used in various fields. This study aimed to determine the phytochemical compound content and the value of lethal toxicity (24-hour LC50) in microalgae D. salina extract with different solvents. The multistage maceration method uses n-hexane, ethyl acetate, and methanol to extract samples. Phytochemical screening uses reagents according to the content of secondary metabolites. The Brine Shrimp Lethality Test method is used to test toxicity. The extracts were tested by using 10 Artemia salina against five concentrations, namely 0, 1, 10, 100, and 1000 ppm. Toxicity data were processed through probit analysis to get the 24-hour LC50 value. The results showed that alkaloids, steroids, triterpenoids, and phenols were found in the methanol, ethyl acetate, and n-hexane extracts. Saponin were found in the methanolic extracts. Flavonoid were found in the methanol and ethyl acetate extracts. The 24-hour LC50 value of the n-hexane extract was 276 ppm, the methanol extract was 811 ppm, and ethyl acetate extract was 673 ppm. The three extracts were included in toxic category. Extracts of microalgae D. salina have plenty secondary metabolite, that can be used in various fields and holds the potential as an anticancer.
Species Composition and Growth Pattern of a Multi-Species Grouper in Kwandang Bay, Sulawesi Sea, Indonesia
Authors: Achmad Dewi Shinta , Nurdin Muh Saleh , Azmi Fauziah , Indrianti Merita Ayu , Hulukati Evi , Jompa Jamaluddin , Haser Teuku Fadlon , Achmad Novianita
Published: January 2023

Highlight Research

There are 26 species identified to be originated from the bay, which the highest diversity in Indonesia
Six species found in Kwandang Bay is showing trends of decreasing populations and two species vulnerable based on IUCN conservation list
Growth model and Fulton condition factor determined for 14 species indicates that they live in a good state of well beings in the bay
The models and condition factors also reflect the adequate food resources required for grouper growth which makes Kwandang Bay as a good habitat for groupers

 
Abstract
Grouper fishery has been the source of income for 3,700 fishermen in Kwandang Bay. Since 2017, grouper populations in Kwandang have been depleting due to the absence of management. This research aimed to analyze species composition, length-weight relationship, and condition factor of the groupers. Samples were collected from fishers who caught the fish using traps, speargun, and handline. Samples were identified through a method by Heemstra and Randall, while the length-weight relationship was estimated using log-linear regression and t-test. The number of specimens identified during January - December 2021 was 1,571 individuals. Research showed that those samples consisted of 26 species under eight genera. Six species found in Kwandang Bay were showing trends of decreasing populations and two species were vulnerable based on the IUCN conservation list. Length-weight relationship analysis of 14 grouper species resulted in b value ranging from 1.6359 to 3.4417 and R2 ranges from 0.7718 to 0.9858. A significant test at a 95% confident interval showed that 14 species had an isometric growth pattern. Fulton condition factors show that Kwandang Bay is an essential habitat for groupers, and the bay can support the fish growth due to the adequate food availability.
Implementation of 16S rRNA Gene for Fish and Shrimp Barcoding in Mangrove Ecosystems in North Sumatra and Aceh, Indonesia
Authors: Hairani Hatika , Rizka Amelia  , Ipanna Enggar Susetya  , Arida Susilowati  , Yuntha Bimantara  , Tadashi Kajita  , Mohammad Basyuni
Published: January 2023

Highlight Research

The genetic diversity of fish and shrimp from mangrove habitats was relatively substantial, with a heterozygosity of 0.926 and the exception of Langsa samples.
AMOVA revealed that the diversity among individuals in the populations were higher compared to those within individuals.
DNA barcode in mangroves is useful in developing mangrove conservation and restoration initiatives

 
Abstract
Fish and shrimp are among the species that are vulnerable to high level of disturbance in mangrove ecosystem. This study aimed to investigate the implementation of 16S rRNA gene for fish and shrimp barcoding in mangrove ecosystems in North Sumatra and Aceh, Indonesia. 50 samples fresh fish and shrimp were collected from five mangrove ecosystems in North Sumatra, namely Belawan, Lubuk Kertang, Percut Sei Tuan, and Pulau Sembilan and Langsa of Aceh for DNA extraction process. The research was divided into four activities: sample collection, DNA isolation, PCR amplification, and data analysis. DNA was extracted using kit extraction (kit Reliaprep gDNA Tissue Miniprep System) and with PCR amplification. Genetic parameters were analyzed using Gen Alex 6.51 software and the relationship between sites was examined using the MVSP 3.22. The genetic diversity of fish and shrimp from mangrove habitats was relatively substantial, according to the findings, with a heterozygosity of 0.926, with the exception of Langsa samples, which were only identified in subclass A1. Genetic relationship between sites revealed that all samples clustered into two branches and were randomly dispersed within each site. This work confirmed the 16S rRNA gene worked for fish and shrimp barcoding in mangrove ecosystems, North Sumatra and Aceh, Indonesia and our findings are expected to be useful in developing mangrove conservation and restoration initiatives.
Sodium Alginate from Padina australis Modulates Innate Immune and Immune Gene Expression in Red Tilapia (Oreochromis sp.)
Authors: Kuswoyo Toni , Isnansetyo Alim , Murwantoko Muwantoko , Husni Amir , Istiqomah Indah
Published: January 2023

Highlight Research

Development of immunostimulant from natural sources is a promising approach to improve the immune status of fish
Dietary administration of sodium alginate from Padina australis at 2.0 g/kg was an effective immunostimulant for red tilapia
Red tilapia fed diet with sodium alginate significantly increased innate immune responses of TLC, PA, respiratory burst, SOD, TPP, lysozyme, and ACH50 activity
Red tilapia fed diet with sodium alginate significantly modulated immune genes expression of GPx, TNF-α, IFN-γ, IL-10, TGF-β1, and Hepcidin
 

Abstract
The study of immunostimulant derived from natural sources has received considerable attention in recent years. Indonesian coasts have various sources of immunostimulant, especially brown algae, which are rich in alginate. This research investigated innate immune response and immune genes in red tilapia (Oreochromis sp.) after being fed diets supplemented with sodium alginates (SA) from a brown alga, Padina australis, originating from Awur Bay, Jepara, Indonesia. This work provided comprehensive information regarding the interaction of cellular-humoral immunity and immune gene expression. Red tilapia was fed with SA-containing diet at doses of 0, 2, 3 and 4 g/kg for 12 days, then blood samples were collected on days 0, 3, 6, 9, and 12 to evaluate the total leucocyte count (TLC), phagocytic activity/index (PA/PI), respiratory burst, superoxide dismutase (SOD), lysozyme, alternative complement (ACH50) activity, total plasma protein (TPP), and immune genes expression (blood sample on day 6). The immunological parameters improved in response to the administered doses and period. Dietary SA enhanced total leucocyte count, phagocytic activity, respiratory burst, superoxide dismutase, lysozyme, and ACH50 activity, whereas the phagocytic index and total plasma protein were not significantly different. Furthermore, the mRNA levels of antioxidant-related gene (GPx), pro-inflammatory cytokines (TNF-α and IFN-γ, except for IL-1β), and antimicrobial peptides (Hepcidin) were upregulated. Meanwhile, anti-inflammatory cytokines (IL-10 and TGF-β1) were downregulated. Supplementation SA diet at 2.0 g/kg as the lowest dose revealed the most effective effects on innate immune and immune genes expression. Dietary SA was a potential immunostimulant in red tilapia aquaculture.
Environmental and genetic risk factors for Parkinson’s disease
Authors: Nikitina M. A. , Alifirova V. M. , Bragina E. Yu. , Babushkina N. P. , Gomboeva D. E. , Nazarenko S. M.
Published: January 2023

Aim. To analyze risk factors in the group of patients with Parkinson’s disease (PD) and compare them with the literature data.

Materials and methods. The study included 439 patients with PD and 354 controls, comparable by gender and age. For each individual, a registration card was filled in containing demographic, epidemiological, clinical, and neuropsychological data. The severity of the disease was studied according to the MDS-UPDRS scale; the stage of PD was determined according to the Hoehn and Yahr scale. Cognitive functions were assessed by the MoCA test and MMSE. The length of the (CAG)n repeat region in the HTT gene was determined using fragment analysis on the ABI 3730 DNA analyzer. The obtained results were analyzed using GeneMapper Software v4.1 (Applied Biosystems, USA).

Results. When comparing patients with PD and the control group, the odds ratio (OR) for PD in individuals with traumatic brain injury was 3.13 (95% confidence interval (CI): 2,27–4.34; p = 4.94 × 10–13), which showed the significance of this risk factor for PD. Consumption of coffee in the anamnesis distinguished the group of PD patients from the control group (OR = 0.41 (95% CI: 0.30–0.56); p < 0.0001), confirming its neuroprotective effect. Analysis of the variability in the length of the (CAG)n repeat regions in the HTT gene showed that patients whose genotype contained an allele with 17 repeats in combination with any allele other than an allele containing 18 repeats had a protective effect (OR = 0.50 (95% CI: 0.27–0.92); p = 0.025). All genotypes containing an allele with 18 repeats were predisposed to PD (OR = 2.57 (95% CI: 1.66–4.28); p = 0.007). The predisposing effect of the allele to PD, unrelated to the expansion of CAG repeats in the HTT gene, was revealed for the first time.

Conclusion. Traumatic brain injury and the allele with 18 CAG repeats in the HTT gene are risk factors for PD. Coffee consumption can be attributed to protective factors in relation to PD.
Assessment of the effect of iron-rich humic substances on hematological parameters in the model of acute posthemorrhagic and iron deficiency anemia
Authors: Bratishko K. A. , Logvinova L. A. , Ivanov V. V. , Zhirkova A. M. , Ufandeew A. A. , Buyko E. E. , Zima A. P. , Rabcevich E. S. , Kuznecova M. V. , Belousov M. V. , Perminova I. V. , Zykova M. V.
Published: January 2023

Aim. To assess the effect of iron-rich humic substances on hematological parameters in acute post-hemorrhagic and iron deficiency anemia.

Materials and methods. Materials for the study were samples of iron-rich active pharmaceutical ingredients based on humic substances (Fe(III) hydroxide complexes with humic substances and polymaltose): HA-Fe3+, HA-PMFe3+, FA-Fe3+, and FA-PM-Fe3+. The anti-anemic activity of the substances was studied on 53 female Wistar rats of the conventional rat line in the model of acute posthemorrhagic and iron deficiency anemia. Anti-anemic activity was assessed by the hemoglobin level, erythrocyte count, hematocrit, and serum iron level.

Results. The studied substances HA-Fe3+ and FA-Fe3+ are the most effective in correcting the consequences of both experimental acute posthemorrhagic anemia and iron deficiency anemia. Their effect is comparable to that of the positive control drug Ferrum Lek.

Conclusion. Fe(III) hydroxide complexes stabilized by humic and fulvic acids exhibit anti-anemic activity.
Prognostic value of short-term trajectories of left ventricular ejection fraction in patients with first myocardial infarction and percutaneous coronary intervention
Authors: Timofeeva T. M. , Kobalava Zh. D. , Safarova A. F. , Cabello M. F.E. , Tigay Zh. G.
Published: January 2023

Aim. To assess periprocedural dynamics of left ventricular ejection fraction (LVEF) in patients with first acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI) without heart failure (HF) in the medical history, as well as its prognostic value in the development of cardiovascular complications in the postinfarction period.

Materials and methods. A prospective, single-center observational study included 131 patients with first AMI without HF in the past medical history and successful PCI. LVEF was assessed before PCI at admission and before discharge. In patients with reduced baseline LVEF of less than 50%, the criteria for its periprocedural improvement were chosen: 1) LVEF ≥ 50%; 2) ΔLVEF of more than 5%, but EF < 50%. The endpoints were hospitalization for the development of HF and death from cardiovascular disease in combination with the development of HF. The average follow-up period was 2.5 years.

Results. At admission, LVEF was < 50% in 74 (56.5%) patients. At discharge, according to the criteria for LVEF improvement, the proportion of patients in this group was 40.5 and 14.9%, respectively. In 44.6% of cases, no increase in LVEF was noted. The predictors of the absence of periprocedural dynamics in LFEF included impaired regional contractility index > 1.94, left ventricular end-systolic volume > 57 ml, left ventricular end-diastolic diameter > 5.1 cm, pulmonary artery systolic pressure >27 mm Hg, NT-proBNP > 530 pg / ml, and E / A ratio > 1.06. During the follow-up period, 28 (21.4%) patients were hospitalized for the development of HF, 33 (25.2%) patients had a combined endpoint. The absence of periprocedural improvement in left ventricular contractility was independently associated with higher odds of hospitalization for HF (relative risk (RR) 3.5; 95% confidence interval (CI) 1.63–7.55; p = 0.001) and the combined endpoint (RR 2.6; 95% CI 1.28–5.48; p = 0.009) in the postinfarction period.

Conclusion. In patients with first AMI and left ventricular systolic dysfunction, periprocedural evaluation of LVEF is reasonable to stratify the risk of adverse cardiovascular outcomes.
Bioinformatic analysis of biological pathways in coronary heart disease and Alzheimer’s disease
Authors: Chasovskikh N. Y. , Chizhik E. E.
Published: January 2023

Aim. Using bioinformatic tools, to perform a pathway enrichment analysis in Alzheimer’s disease and coronary heart disease (CHD).

Materials and methods. Genes contributing to susceptibility to CHD and Alzheimer’s disease were obtained from the public database DisGeNET (Database of Gene – Disease Associations). A pathway enrichment analysis was performed in the ClueGO Cytoscape plug-in (version 3.6.0) using hypergeometric distribution and the KEGG and Reactome databases.

Results. The identified genes contributing to susceptibility to Alzheimer’s disease and CHD are included in 69 common signaling pathways, grouped into the following subgroups: cell death signaling pathways (1); signaling pathways regulating immune responses (2); signaling pathways responsible for fatty acid metabolism (3); signaling pathways involved in the functioning of the nervous system (4), cardiovascular system (5), and endocrine system (6).

Conclusion. Following the performed analysis, we identified possible associations between processes involving genetic factors and their products in CHD and Alzheimer’s disease. In particular, we assumed that susceptibility genes involved in the implementation of these pathways regulate apoptosis, production of inflammatory cytokines and chemokines, lipid metabolism, β-amyloid formation, and angiogenesis.
KNOWLEDGE FOR THE IMPLEMENTATION OF SUSTAINABLE TOURISM DEVELOPMENT - STUDENTS’ ATTITUDES
Authors: Smolčić Jurdana Dora , Agbaba Romina
Published: January 2023

Purpose – The purpose of the paper is to analyse students’ attitudes about the concept of sustainable development and knowledge significant for its implementation in tourism. More precisely, the aim was to determine which knowledge students perceive as particularly important for the application of sustainable development and whether there are significant differences in the attitudes of students of different years of study regarding gender, year and status (full time and part time students) of study. Methodology – For the formation of the theoretical part, secondary data sources were used, based on the analysis of relevant literature in the field of sustainable tourism development, such are articles and reports. The research part includes quantitative data collection based on an online questionnaire distributed to students of the Faculty of Tourism and Hospitality Management of all years, enrolled in the study of Management of Sustainable Development, to assess the importance of relevant knowledge about the sustainable development and also their own knowledge in this f ield. Data processing was performed through the statistical program for social sciences - SPSS while descriptive statistics were used for the purposes of data processing and interpretation. Findings – Based on the conducted research, the respondents evaluated the importance of knowledge for the implementation of sustainable development of tourism regarding environmental, social and economic aspects. In addition, the respondents expressed personal assessments of their level of knowledge/habits/actions in the mentioned areas. Also, differences will be determined with regarding the gender, field and year of study of the respondents. Respondents mostly show positive attitudes towards sustainable development and assess the importance of further education for sustainable development. The emphasis should be on acquiring knowledge related to sustainable development, developing abilities and skills that will help in facing the challenges of the 21st century, through organizing workshops, debates, learning to solve problems, promoting extracurricular activities such as volunteering or participating in local community projects, etc. Contribution – Contribution of the paper is in identifying and ranking the importance of specific knowledge for sustainable development from the perspective of students. According to the results, new educational programs of student interest could be developed. This research presents an opportunity for students to develop a methodological approach to the self-assessment process through a questionnaire.