bluuebunny/crossref_metadata_2025 huggingface dataset:
Silver Diamine Fluoride in Pediatric Dentistry: Effectiveness in Preventing and Arresting Dental Caries—A Systematic Review
Authors: Muntean Alexandrina , Mzoughi Soundouss Myriam , Pacurar Mariana , Candrea Sebastian , Inchingolo Alessio Danilo , Inchingolo Angelo Michele , Ferrante Laura , Dipalma Gianna , Inchingolo Francesco , Palermo Andrea , Bordea Ioana Roxana
Published: April 2024

Background: Tooth decay is considered a global scourge by the World Health Organization (WHO) starting at an early age. In recent years, silver diamine fluoride (SDF) has regained interest, particularly in pediatric dentistry, used to prevent the development of carious lesions or arrest their progression. Objective: The aim of this study was to assess, through a systematic review of the literature, the effectiveness of SDF, used in pedodontics, in temporary teeth, in preventing or arresting dental caries. Material and Methods: An electronic search was conducted on PubMed, Web of Science and Scopus. The effect of SDF on both temporary and permanent teeth has been considered. Results: The inclusion criteria identified 16 randomized controlled trials involving patients aged 18 months to 13 years and followed over a period of 12–30 months. Conclusions: SDF is a practical, accessible and effective non-invasive way to prevent and arrest caries in temporary and permanent teeth. Its application requires regular monitoring. The resulting black spot is diminished by immediate application of potassium iodide but this may affect its effectiveness.
Amnioreduction for Polyhydramnios in a Consecutive Series at a Single Center: Indications, Risks and Perinatal Outcomes
Authors: Laoreti Arianna , Sala Valentina , Casati Daniela , Faiola Stefano , Spaccini Luigina , Cetin Irene , Lanna Mariano M.
Published: April 2024

Pregnancies complicated by severe polyhydramnios are associated with a high rate of underlying fetal anomaly. Amnioreduction may be offered to alleviate maternal symptoms. This is a retrospective study of amnioreductions performed on singleton and twin gestations complicated by symptomatic polyhydramnios between 2010 and 2023 at our tertiary referral center. The indications, procedural techniques and pregnancy and neonatal outcomes were retrieved from an archive database and reviewed with the use of the maternal and child medical record chart, the hospital electronic clinical discharge report and telephone recalls. Our study comprised 86 pregnancies, 65 singletons and 21 twin pregnancies. Fetal anomalies were identified in 79% of cases, mainly gastrointestinal obstructive anomalies; 9.3% of cases were idiopathic. The median gestational age at first amnioreduction was 32.5 weeks, and peri-procedural complications were rare (1 case of placental abruption and 2 cases of preterm delivery). The median gestational age at delivery was 36.5 weeks, with a median prolongation of the pregnancy from the time of first drain until birth of 30 days. Preterm labor < 37 weeks occurred in 48.8% of procedures, with 26.7% of patients delivering before 34 weeks and pPROM < 36 weeks recorded in 23.2% of cases. In conclusion, amnioreduction offered to alleviate maternal symptoms is a reasonably safe procedure with a low complication rate. These pregnancies necessitate management in a tertiary referral center because of their need for a multidisciplinary approach both prenatally and postnatally.
Signaling Transduction Pathways and G-Protein-Coupled Receptors in Different Stages of the Embryonic Diapause Termination Process in Artemia
Authors: Hao Tong , Song Zhentao , Zhang Mingzhi , Zhang Lingrui
Published: April 2024

Artemia is a widely distributed small aquatic crustacean, renowned for its ability to enter a state of embryonic diapause. The embryonic diapause termination (EDT) is closely linked to environmental cues, but the precise underlying mechanisms remain elusive. In this study, ATAC-seq and RNA-seq sequencing techniques were employed to explore the gene expression profiles in Artemia cysts 30 min after EDT. These profiles were compared with those during diapause and 5 h after EDT. The regulatory mechanisms governing the EDT process were analyzed through Gene Ontology (GO) enrichment analysis of differentially expressed genes. Furthermore, the active G-protein-coupled receptors (GPCRs) were identified through structural analysis. The results unveiled that the signaling transduction during EDT primarily hinges on GPCRs and the cell surface receptor signaling pathway, but distinct genes are involved across different stages. Hormone-mediated signaling pathways and the tachykinin receptor signaling pathway exhibited heightened activity in the ‘0–30 min’ group, whereas the Wnt signaling pathway manifested its function solely in the ‘30 min–5 h’ group. These results imply a complete divergence in the mechanisms of signal regulation during these two stages. Moreover, through structural analysis, five GPCRs operating at different stages of EDT were identified. These findings provide valuable insights into the signal regulation mechanisms governing Artemia diapause.
Associations between Sleep Hygiene and Mental Complaints in a French Healthcare Worker Population during the COVID-19 Crisis: A Cross-Sectional Analysis to Personalize Sleep Health Interventions
Authors: Coelho Julien , Micoulaud-Franchi Jean-Arthur , Philip Pierre
Published: April 2024

Healthcare workers often have irregular work schedules and experience significant stress, which can lead to poor sleep quality and frequent mental health issues, especially in the context of the COVID-19 pandemic. In this cross-sectional study, we aimed to assess the prevalence of poor sleep hygiene and mental health complaints among healthcare workers and examine their associations. We investigated participants’ typical sleep–wake patterns on workdays and free days as indicators of sleep hygiene. Sleep efficiency and social jetlag were calculated as the ratio of mean sleep duration to time spent in bed, while sleep rebound was defined as the difference in mean sleep duration between workdays and free days. Social jetlag was determined as the difference in mid-sleep timing between workdays and free days, with mid-sleep defined as the midpoint between bedtime and wake-up time. Insomnia severity was assessed using the Insomnia Severity Index (ISI), daytime sleepiness using the Epworth Sleepiness Scale (ESS), and symptoms of anxiety and depression using the Patient Health Questionnaire 4 (PHQ-4). Fatigue was measured using a single item inspired by the Maslach Burnout Inventory (MBI). A total of 1562 participants (80.5% women, mean age 40.0 years) were included in the study. The results revealed that 25.9% of participants slept less than 6 h, 24.3% had a sleep efficiency of less than 85%, 27.3% experienced a sleep rebound of more than 2 h, and 11.5% reported a social jetlag exceeding 2 h. Additionally, 33.9% of participants reported insomnia, 45.1% reported excessive daytime sleepiness, 13.1% reported fatigue, 16.5% reported symptoms of depression, and 35.7% reported symptoms of anxiety. After adjustment, mean sleep duration and sleep efficiency were associated with most mental health complaints. Sleep rebound and social jetlag were associated with significant insomnia but not with anxiety or depression symptoms. Our findings underscore the high prevalence of poor sleep hygiene and mental health complaints among healthcare workers, exacerbated by the COVID-19 crisis. We advocate for the promotion of sleep health through behavioral sleep strategies to safeguard the well-being of healthcare professionals.
A Weighted and Epsilon-Constraint Biased-Randomized Algorithm for the Biobjective TOP with Prioritized Nodes
Authors: Agud-Albesa Lucia , Garrido Neus , Juan Angel A. , Llorens Almudena , Oltra-Crespo Sandra
Published: April 2024

This paper addresses a multiobjective version of the Team Orienteering Problem (TOP). The TOP focuses on selecting a subset of customers for maximum rewards while considering time and fleet size constraints. This study extends the TOP by considering two objectives: maximizing total rewards from customer visits and maximizing visits to prioritized nodes. The MultiObjective TOP (MO-TOP) is formulated mathematically to concurrently tackle these objectives. A multistart biased-randomized algorithm is proposed to solve MO-TOP, integrating exploration and exploitation techniques. The algorithm employs a constructive heuristic defining biefficiency to select edges for routing plans. Through iterative exploration from various starting points, the algorithm converges to high-quality solutions. The Pareto frontier for the MO-TOP is generated using the weighted method, epsilon-constraint method, and Epsilon-Modified Method. Computational experiments validate the proposed approach’s effectiveness, illustrating its ability to generate diverse and high-quality solutions on the Pareto frontier. The algorithms demonstrate the ability to optimize rewards and prioritize node visits, offering valuable insights for real-world decision making in team orienteering applications.
Detecting Overlapping Communities Based on Influence-Spreading Matrix and Local Maxima of a Quality Function
Authors: Kuikka Vesa
Published: April 2024

Community detection is a widely studied topic in network structure analysis. We propose a community detection method based on the search for the local maxima of an objective function. This objective function reflects the quality of candidate communities in the network structure. The objective function can be constructed from a probability matrix that describes interactions in a network. Different models, such as network structure models and network flow models, can be used to build the probability matrix, and it acts as a link between network models and community detection models. In our influence-spreading model, the probability matrix is called an influence-spreading matrix, which describes the directed influence between all pairs of nodes in the network. By using the local maxima of an objective function, our method can standardise and help in comparing different definitions and approaches of community detection. Our proposed approach can detect overlapping and hierarchical communities and their building blocks within a network. To compare different structures in the network, we define a cohesion measure. The objective function can be expressed as a sum of these cohesion measures. We also discuss the probability of community formation to analyse a different aspect of group behaviour in a network. It is essential to recognise that this concept is separate from the notion of community cohesion, which emphasises the need for varying objective functions in different applications. Furthermore, we demonstrate that normalising objective functions by the size of detected communities can alter their rankings.
Cognitive Classifier of Hand Gesture Images for Automated Sign Language Recognition: Soft Robot Assistance Based on Neutrosophic Markov Chain Paradigm
Authors: Al-Saidi Muslem , Ballagi Áron , Hassen Oday Ali , Saad Saad M.
Published: April 2024

In recent years, Sign Language Recognition (SLR) has become an additional topic of discussion in the human–computer interface (HCI) field. The most significant difficulty confronting SLR recognition is finding algorithms that will scale effectively with a growing vocabulary size and a limited supply of training data for signer-independent applications. Due to its sensitivity to shape information, automated SLR based on hidden Markov models (HMMs) cannot characterize the confusing distributions of the observations in gesture features with sufficiently precise parameters. In order to simulate uncertainty in hypothesis spaces, many scholars provide an extension of the HMMs, utilizing higher-order fuzzy sets to generate interval-type-2 fuzzy HMMs. This expansion is helpful because it brings the uncertainty and fuzziness of conventional HMM mapping under control. The neutrosophic sets are used in this work to deal with indeterminacy in a practical SLR setting. Existing interval-type-2 fuzzy HMMs cannot consider uncertain information that includes indeterminacy. However, the neutrosophic hidden Markov model successfully identifies the best route between states when there is vagueness. This expansion is helpful because it brings the uncertainty and fuzziness of conventional HMM mapping under control. The neutrosophic three membership functions (truth, indeterminate, and falsity grades) provide more layers of autonomy for assessing HMM’s uncertainty. This approach could be helpful for an extensive vocabulary and hence seeks to solve the scalability issue. In addition, it may function independently of the signer, without needing data gloves or any other input devices. The experimental results demonstrate that the neutrosophic HMM is nearly as computationally difficult as the fuzzy HMM but has a similar performance and is more robust to gesture variations.
Blockchain Integration and Its Impact on Renewable Energy
Authors: Taherdoost Hamed
Published: April 2024

This paper investigates the evolving landscape of blockchain technology in renewable energy. The study, based on a Scopus database search on 21 February 2024, reveals a growing trend in scholarly output, predominantly in engineering, energy, and computer science. The diverse range of source types and global contributions, led by China, reflects the interdisciplinary nature of this field. This comprehensive review delves into 33 research papers, examining the integration of blockchain in renewable energy systems, encompassing decentralized power dispatching, certificate trading, alternative energy selection, and management in applications like intelligent transportation systems and microgrids. The papers employ theoretical concepts such as decentralized power dispatching models and permissioned blockchains, utilizing methodologies involving advanced algorithms, consensus mechanisms, and smart contracts to enhance efficiency, security, and transparency. The findings suggest that blockchain integration can reduce costs, increase renewable source utilization, and optimize energy management. Despite these advantages, challenges including uncertainties, privacy concerns, scalability issues, and energy consumption are identified, alongside legal and regulatory compliance and market acceptance hurdles. Overcoming resistance to change and building trust in blockchain-based systems are crucial for successful adoption, emphasizing the need for collaborative efforts among industry stakeholders, regulators, and technology developers to unlock the full potential of blockchains in renewable energy integration.
Impact of Hair Damage on the Penetration Profile of Coconut, Avocado, and Argan Oils into Caucasian Hair Fibers
Authors: Lourenço Carolina Botelho , Gasparin Rebeca Mantuan , Thomaz Fernanda Malanconi , da Silva Gustavo Carlos , Martin Airton Abrahao , Paiva-Santos Ana Cláudia , Mazzola Priscila Gava
Published: April 2024

The mitigation of damaged hair conditions involves the application and penetration of substances to stabilize broken bond sites, restore lipids and proteins, reinstate hydrophobicity, and recover hair mechanical properties. Vegetable oils, in general, exhibit a list of advantageous characteristics much desired by consumers, given the associated benefits for hair fibers. While coconut oil is highly popular in the hair care market and extensively studied for its ability to diffuse through the hair cortex, the effects of avocado and argan oil on the internal structure of hair and their potential benefits remain underexplored. Tensile and fatigue tests, as well as Raman spectroscopy, were carried out to investigate the interaction of these three oils with virgin and bleached Caucasian hair. The oils were applied in sufficient amounts directly to hair tresses and maintained for 24 h at 25 °C. Our results show that the three oils successfully diffused and interacted with the cortical region of the hairs. Their impact on hair mechanical properties depends on the level of damage and humidity conditions. In virgin hair, coconut and avocado oil reinforce the hydrophobic barrier of the cellular membrane complex, preventing water from causing intense perturbation of the mechanical properties, leading to increased stiffness and break stress. Meanwhile, due to the high degree of unsaturation of its fatty acid chains, argan oil increases water absorption, resulting in losses in hair resistance. When bleached, the hydrophilicity of the hair fiber increases, determining more affinity for argan oil. Consequently, the affinity with water is also elevated, causing increased fragility to mechanical stress. The analyzed vegetable oils are not always beneficial for hair care. Their specific chemical characteristics and hair conditions will influence the final results and should be taken into consideration in hair care product development.
An Engineered Minimal-Set Stimulus for Periodic Information Leakage Fault Detection on a RISC-V Microprocessor
Authors: Somoye Idris O. , Plusquellic Jim , Mannos Tom J. , Dziki Brian
Published: April 2024

Recent evaluations of counter-based periodic testing strategies for fault detection in Microprocessor (μP) have shown that only a small set of counters is needed to provide complete coverage of severe faults. Severe faults are defined as faults that leak sensitive information, e.g., an encryption key on the output of a serial port. Alternatively, fault detection can be accomplished by executing instructions that periodically test the control and functional units of the μP. In this paper, we propose a fault detection method that utilizes an ’engineered’ executable program combined with a small set of strategically placed counters in pursuit of a hardware Periodic Built-In-Self-Test (PBIST). We analyze two distinct methods for generating such a binary; the first uses an Automatic Test Generation Pattern (ATPG)-based methodology, and the second uses a process whereby existing counter-based node-monitoring infrastructure is utilized. We show that complete fault coverage of all leakage faults is possible using relatively small binaries with low latency to fault detection and by utilizing only a few strategically placed counters in the μP.
Crystallization of Polymers with a Reduced Density of Entanglements
Authors: Pawlak Andrzej
Published: April 2024

Since methods for reducing macromolecule entanglements have been developed, it has become possible to better understand the impact of polymer chain entanglement on the crystallization process. The article presents basic information about the disentangling of macromolecules and the characterization of the degree of entanglement. The basic knowledge of polymer crystallization was also presented. Then, it was discussed how polymers crystallize during their disentangling. Non-isothermal and isothermal crystallization experiments using disentangled polymers, and for comparison using entangled polymers, are described in more detail. The influence of disentangling on both nucleation and crystal growth is highlighted. It is also shown how the crystallization of polymers changes when macromolecules re-entangle.
Formation and Evolution of Interfacial Structure in Al–Si–Mg/Stainless Steel Bimetals during Hot-Dipping Process
Authors: Kim Byung-Joo , Lim Ha-Yoon , Kayani Saif Haider , Lee Yun-Soo , Kim Su-Hyeon , Cha Joon-Hyeon
Published: April 2024

Understanding trends in the formation of the intermetallic compound (IMC) layer in Al/Fe bimetallic composites can aid in significantly improving their mechanical properties. However, it is currently challenging to predict IMC layer formation during hot-dip aluminizing. Furthermore, the results from previous studies are difficult to compare owing to the variation in the process parameters used. Therefore, to understand how temperatures and holding times affect the thickness and hardness properties of IMC layers, we investigated the interfacial properties of aluminized stainless steel in molten Al-Si-Mg. AISI 420 stainless steel was hot-dip aluminized in an Al–Si–Mg alloy melt for 10–120 min at four different temperatures: 700, 750, 800, and 850 °C. Morphology, type, and element distribution of the phases formed in the reaction layer and the reduction rate of the aluminizing process were studied. Notably, while the reaction layer thickness increased with increasing aluminizing temperature when the holding time was low, long-term reaction caused the reaction layer to become thicker at lower temperatures. The mechanism of this morphological transformation is discussed. The results demonstrated effective trends in controlling the morphology of the intermetallic compound layer with respect to various hot-dip Al plating process parameters.
Origin of Color and Spectral Characteristics of Nanhong Agate from Northeast Yunnan, China
Authors: Song Qiuyun , Chen Liurunxuan , Zuo Ruohan , Chen Xianchao , Sui Sugang , Pu Wenzhou , Yang Xiaoqi , Zhang Shitao , Liu Wenlian
Published: April 2024

Nanhong agate has attracted public attention as the most distinctive gemstone in China. Owing to the limited data on Nanhong agates from a new production area in northeastern Yunnan, this paper presents the first data from gemological studies on these agates. Complex investigations using Fourier-transform infrared (FTIR) spectrometry, ultraviolet–visible (UV–VIS) luminescence spectrometry, Raman spectroscopy, polarizing microscopy, scanning electron microscopy (SEM), electron microprobe (EPMA), and laser ablation–inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses were carried out to obtain basic data concerning the gemological properties, microstructure, and spectroscopic and geochemical characteristics of this interesting material. The results illustrate that Nanhong agates from northeastern Yunnan are mainly composed of α-quartz and also contain certain amounts of moganite, illite, goethite, and hematite. The typical red (yellow) and white appearance can be attributed to the microstructure of the agates, the contents of Fe and Al impurities, and trace elements. The Raman spectra, microstructure, and chemical composition of the unique “yellow-skinned” agates from northeastern Yunnan are significantly different from those of other types of Nanhong agate. This work lays a foundation for the future identification and research of this type of Nanhong agate.
Gastro-Intestinal Symptoms in Palliative Care Patients
Authors: Tradounsky Golda Elisa
Published: April 2024

This review of the palliation of various gastro-intestinal (GI) symptoms encountered in cancer patients is by no means exhaustive. Frequent symptoms such as constipation, nausea and vomiting, bowel obstructions, ascites and bleeds will be discussed, focusing on their assessment and most importantly, how to control the associated symptoms. All of these symptoms and GI complications can significantly impact patients’ quality of life (QOL) and should be treated as quickly and aggressively as possible.
Ascochyta erotica sp. nov. Pathogenic on Convolvulus arvensis
Authors: Gomzhina Maria , Gasich Elena
Published: April 2024

Convolvulus arvensis is an herbaceous dicotyledonous plant in the Convolvulaceae family that is native to Europe and Asia. It is a perennial soboliferous plant and is one of the most harmful weeds. This weed is successful in many types of climates, including temperate, tropical, and Mediterranean climates, but it is most troublesome for agriculture throughout the temperate zone. In this study, several pathogenic isolates were collected from this host. The internal transcribed spacer (ITS) and large subunit (28S) or ribosomal DNA, partial DNA-directed RNA polymerase II subunit (rpb2), and β-tubulin (tub2) genes were amplified and sequenced for all the isolates studied. Further, both a multilocus phylogenetic analysis of DNA sequences and an analysis of morphological features were implemented. Based on the results obtained, all the studied isolates were found to be distinct from any described species in the genus Ascochyta and are, therefore, described here as a new species Ascochyta erotica sp. nov. The pathogenicity of A. erotica sp. nov. was also tested and confirmed on leaf segments of C. arvensis.
Phylogenetic Trends in the Dissymmetrisation of Genitalia in Hadenini (Lepidoptera, Noctuidae)
Authors: Varga Zoltán , Ronkay Gábor , Ronkay László
Published: April 2024

The external genital appendages of Noctuidae represent correlated–coevolved elements of a complex structure. The pathways of changes are delimited by some constraints, and they are parallelly evolved in different phyletic lines. Asymmetrical male external genitalia were found in Hadenini, in Polia and its closely related genera, but also in Anarta (s. l.). In Poliina, the asymmetry of the genital capsule is mostly expressed in the Holarctic Polia nebulosa species group, forming the basal split within Polia (s. str.). Higher species diversity, as a consequence of asymmetry connected with the split of functions between the right and left sides, was observed in Polia (s. str.) and in Anarta (s. l.). The highest level of expansivity was observed in the Holarctic Anarta, where some species are migrating and becoming invasive ones, while a bulk of species populates the steppic and mountainous habitats of North America and Central Asia. Parallelly, while some genera/subgenera of the subtribe Poliina are oligotypic and/or consist of strictly localised species, the sensu stricto Polia species with asymmetrical genital capsules are widely distributed. The diversification of the Hadulina phylogenetic line should have been initiated by the Messinian aridisation crisis. The core area of diversification of Poliina was connected with the Sino-Himalayan region, followed by expansion into the Holarctic boreo-nemoral zone.
Management Strategies of Prosopis juliflora in Eastern Africa: What Works Where?
Authors: Kamiri Hellen Wangechi , Choge Simon K. , Becker Mathias
Published: April 2024

Prosopis juliflora is a shrub/tree originating from the Americas. Since its introduction for fuel wood afforestation into eastern Africa, it has been invading crop- and rangelands with negative effects on the environment and on livelihoods. Understanding the management strategies for Prosopis and matching them with ecological, social-cultural, and economic needs of the eastern African region is a pressing scientific issue. We analyzed management strategies of Prosopis, focusing on determinants and drivers of their choice of applied management strategies as well as their effectiveness. We identified 1917 scientific contributions published between 1970 and 2022. Following a multi-step screening, we reduced the references to 53 relevant (internationally) published papers with a focus on the management of Prosopis in the east African region. Analysis of the literature shows that factors driving invasion dynamics but also land users’ social-economic as well as cultural attributes determine the type of management strategy and shape local control actions. Main strategies comprise (1) physical containment of invasive spread, (2) chemical, mechanical and biological approaches to reduce stand densities, (3) complete eradication, (4) restoration of invaded land, and (5) economic use of Prosopis products. Adopted strategies are based on actual and perceived impacts of invasion, and the adoption and success of individual strategies is highly location specific.
Associations between Epiphytic Orchids and Their Hosts and Future Perspectives of These in the Context of Global Warming
Authors: Timsina Binu , Münzbergová Zuzana , Kindlmann Pavel , Bhattarai Bishnu Prasad , Shrestha Bikram , Raskoti Bhakta B. , Rokaya Maan B.
Published: April 2024

Epiphytic species are ecologically important and a significant component of biodiversity. To ensure their efficient conservation, we need to understand their ecology and host plant associations. It is also important to investigate how the predicted temperature change will affect their future distribution. Here, we use data collected in Nepal to investigate how epiphytic orchids are associated with host species, their distribution patterns, and how they may be threatened by the predicted increase in temperature towards the end of the 21st century. We used the phi coefficient (Φ) of association to calculate the associations of epiphytic orchid species with plants and rarefaction to describe the diversity of orchids associated with a particular host species. We used interpolation to estimate the distribution of epiphytic orchids and their host species along altitudinal gradients. The phi (Φ) coefficient of association revealed that 30 species of host plants showed more association with different orchid species than expected. The number of epiphytic orchids increased with the number of host individuals. We predict that an increase in temperature by ~3 °C, which is a more moderate value of temperature increase by the end of the 21st century, will affect at least 52 narrow-ranged species of orchids and 58 narrow-ranged species of host plants. Therefore, we should make efforts to prevent many plant species from becoming extinct, as an increase in temperature is likely to affect their existence.
Mapping of Data-Sharing Repositories for Paediatric Clinical Research—A Rapid Review
Authors: Felisi Mariagrazia , Bonifazi Fedele , Toma Maddalena , Pansieri Claudia , Leary Rebecca , Hedley Victoria , Cornet Ronald , Reggiardo Giorgio , Landi Annalisa , D’Ercole Annunziata , Malik Salma , Nally Sinéad , Sen Anando , Palmeri Avril , Bonifazi Donato , Ceci Adriana
Published: April 2024

The reuse of paediatric individual patient data (IPD) from clinical trials (CTs) is essential to overcome specific ethical, regulatory, methodological, and economic issues that hinder the progress of paediatric research. Sharing data through repositories enables the aggregation and dissemination of clinical information, fosters collaboration between researchers, and promotes transparency. This work aims to identify and describe existing data-sharing repositories (DSRs) developed to store, share, and reuse paediatric IPD from CTs. A rapid review of platforms providing access to electronic DSRs was conducted. A two-stage process was used to characterize DSRs: a first step of identification, followed by a second step of analysis using a set of eight purpose-built indicators. From an initial set of forty-five publicly available DSRs, twenty-one DSRs were identified as meeting the eligibility criteria. Only two DSRs were found to be totally focused on the paediatric population. Despite an increased awareness of the importance of data sharing, the results of this study show that paediatrics remains an area in which targeted efforts are still needed. Promoting initiatives to raise awareness of these DSRs and creating ad hoc measures and common standards for the sharing of paediatric CT data could help to bridge this gap in paediatric research.
Predictors of Early Continence Recovery Following Radical Prostatectomy, Including Transperineal Ultrasound to Evaluate the Membranous Urethra Length (CHECK-MUL Study)
Authors: Barakat Bara , Addali Mustapha , Hadaschik Boris , Rehme Christian , Hijazi Sameh , Zaqout Samy
Published: April 2024

Introduction: To predict early continence recovery following radical prostatectomy (RP) using baseline demographic and clinical data, as well as dynamic transperineal ultrasound (TPUS) parameters of membranous urethral length (MUL). Patients and Methods: A retrospective CHECK-MUL (check of membranous urethral length) study was conducted. We evaluated 154 patients who underwent RP between August 2018 and April 2023. All patients underwent pre- and postoperative dynamic TPUS to measure MUL. Urinary continence was defined as the use of one safety pad or less 3 months post surgery. The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) was used to assess urinary incontinence (UI). We used logistic regression to assess the association between MUL and early continence recovery. A multivariable logistic regression model was then constructed for the prediction of early continence recovery based on the MUL. Results: The median MUL observed pre- and postoperatively in this study were similar (14.6 mm and 12.9 mm). In the univariable logistic regression analysis, the pre- and postoperative MUL measured by TPUS (odds ratio (OR): 1.12; 95%-CI: 1.02–1.79; p = 0.05 and OR: 1.01; 95%-CI: 1.02–1.12; p < 0.01) directions were independent predictors of early continence recovery 3 months post surgery. In addition, age (OR: 1.23; 95%-CI: 1.11–1.42; p = 0.03), BMI (OR: 1.44; 95%-CI: 1.18–2.92; p = 0.05), and bilateral nerve sparing (OR: 1.24; 95%-CI: 1.02–1.9; p = 0.05) were independent predictors of urinary continence in univariable logistic regression models. Preoperative MUL >15 mm (95% CI 1.28–1.33; p = 0.03) and postoperative MUL >14 mm (95% CI 1.2–1.16; p = 0.05) were significantly associated with early continence recovery at 3 months post surgery. Conclusions: The likelihood of continence recovery increases with membranous urethral length and decreases with age, BMI, and lack of nerve sparing. Preoperative MUL >15 mm and postoperative MUL >14 mm were significantly associated with early continence recovery at 3 months post surgery.
Breaking Sound Barriers: Exploring Tele-Audiology’s Impact on Hearing Healthcare
Authors: Lin Mien-Jen , Chen Chin-Kuo
Published: April 2024

Hearing impairment is a global issue, affecting billions of people; however, there is a gap between the population affected by hearing loss and those able to access hearing healthcare. Tele-audiology, the application of telemedicine in audiology, serves as a new form of technology which aims to provide synchronous or asynchronous hearing healthcare. In this article, we reviewed some recent studies of tele-audiology-related topics to have a glimpse of the current development, associated challenges, and future advancement. Through the utilization of tele-audiology, patients can conveniently access hearing healthcare, and thus save travel costs and time. Recent studies indicate that remote hearing screening and intervention are non-inferior to the performance of traditional clinical pathways. However, despite its potential benefits, the implementation of tele-audiology faces numerous challenges, and audiologists have varying attitudes on this technology. Overcoming obstacles such as high infrastructure costs, limited reimbursement, and the lack of quality standards calls for concerted efforts to develop effective strategies. Ethical concerns, reimbursement, and patient privacy are all crucial aspects requiring in-depth discussion. Enhancing the education and training of students and healthcare workers, along with providing relevant resources, will contribute to a more efficient, systematic hearing healthcare. Future research will aim to develop integrated models with evidence-based protocols and incorporating AI to enhance the affordability and accessibility of hearing healthcare.
Myxofibrosarcoma of the Chest Wall Detected on 99mTc-MDP Whole-Body Bone Scan
Authors: Lee Chia-Hsuan , Shen Hueng-Yuan (Daniel) , Shiue Yow-Ling (Shirley) , Chan Hung-Yen , Chan Hung-Pin
Published: April 2024

Myxofibrosarcoma is a type of soft tissue sarcoma, predominantly characterized by a high propensity for local recurrence, albeit demonstrating a relatively diminished risk for distant metastasis. Its prevalence is notably higher in elderly patients. Here, we present a case of a 73-year-old woman diagnosed with Myxofibrosarcoma. She was subjected to a whole-body bone scan using 99mTc-methylene diphosphonate (MDP) to survey potential bony metastasis. It revealed marked MDP accumulation with peripheral soft tissue uptake in the right lateral chest region of this patient. This imaging phenotype could potentially be attributed to the augmented vascularity within the tumor, a finding that was prominently displayed in this particular case.
Diabetes Mellitus and Pneumococcal Pneumonia
Authors: Cilloniz Catia , Torres Antoni
Published: April 2024

Currently, there are more than 500 million people suffering from diabetes around the world. People aged 65 years or older are the most affected by this disease, and it is estimated that approximately 96% of diabetes cases worldwide are type 2 diabetes. People with diabetes mellitus are at an increased risk of infections such as pneumonia, due to a series of factors that may contribute to immune dysfunction, including hyperglycemia, inhibition of neutrophil chemotaxis, impaired cytokine production, phagocytic cell dysfunction, altered T cell-mediated immune responses and the co-existence of chronic comorbidities. Rates of infection, hospitalization and mortality in diabetic patients are reported to be higher than in the general population. Research into the risk of infectious diseases such as pneumonia in these patients is very important because it will help improve their management and treatment.
A Systematic Review of the Relationship between Serum Vitamin D Levels and Caries in the Permanent Teeth of Children and Adolescents
Authors: Buzatu Roxana , Luca Magda Mihaela , Bumbu Bogdan Andrei
Published: April 2024

This systematic review critically evaluates the association between serum Vitamin D levels and dental caries incidence in the permanent teeth of children and adolescents. The search strategy comprised three databases (PubMed, Scopus, Embase), up to November 2023, targeting studies on the correlation between Vitamin D and dental caries in permanent dentition. The eligibility criteria focused on observational studies involving children and adolescents aged 12 to 19 years with permanent dentition. The screening process, guided by the PRISMA guidelines and the Newcastle–Ottawa Scale for quality assessment, resulted in the inclusion of eight studies conducted across various global regions from 2013 to 2023. The analysis revealed that Vitamin D insufficiency and deficiency were prevalent among the study populations, ranging from 17.3% to 69.4%. Specifically, children and adolescents with Vitamin D insufficiency (<50 nmol/L) were found to have significantly higher odds of developing caries, with odds ratios (ORs) ranging from 1.13 to 2.57. Conversely, two studies indicated a protective effect of higher Vitamin D levels, with an OR of 0.80 and 0.59, respectively, for caries among children and adolescents with serum levels ≥ 50 nmol/L, suggesting an inverse relationship between Vitamin D status and caries risk. The results indicate both the protective role of adequate serum levels of Vitamin D above 20 ng/mL and the increased risk associated with insufficient levels below this threshold. However, the variations in study quality, methodologies and geographic settings underscore the challenges in drawing universal conclusions. Despite these limitations, our review suggests that improving Vitamin D status could be a beneficial component of preventive strategies against dental caries in children and adolescents, warranting further research to clarify the clinical significance of our findings.
A Study on Anti-Jamming Algorithms in Low-Earth-Orbit Satellite Signal-of-Opportunity Positioning Systems for Unmanned Aerial Vehicles
Authors: Yao Lihao , Qin Honglei , Gu Boyun , Shi Guangting , Sha Hai , Wang Mengli , Xian Deyong , Chen Feiqiang , Lu Zukun
Published: April 2024

Low-Earth-Orbit (LEO) satellite Signal-of-Opportunity (SOP) positioning technology has gradually matured to meet the accuracy requirements for unmanned aerial vehicle (UAV) positioning in daily scenarios. Advancements in miniaturization technology for positioning terminals have also made this technology’s application to UAV positioning crucial for UAV development. However, in the increasingly complex electromagnetic environment, there remains a significant risk of degradation in positioning performance for UAVs in LEO satellite SOP positioning due to unintentional or malicious jamming. Furthermore, there is a lack of in-depth research from scholars both domestically and internationally on the anti-jamming capabilities of LEO satellite SOP positioning technology. Due to significant differences in the downlink signal characteristics between LEO satellites and Global Navigation Satellite System (GNSS) signals based on Medium Earth Orbit (MEO) or Geostationary Earth Orbit (GEO) satellites, the anti-jamming research results of traditional satellite navigation systems cannot be directly applied. This study addresses the narrow bandwidth and high signal-to-noise ratio (SNR) characteristics of signals from LEO satellite constellations. We propose a Consecutive Iteration based on Signal Cancellation (SCCI) algorithm, which significantly reduces errors during the model fitting process. Additionally, an adaptive variable convergence factor was designed to simultaneously balance convergence speed and steady-state error during the iteration process. Compared to traditional algorithms, simulation and experimental results demonstrated that the proposed algorithm enhances the effectiveness of jamming threshold settings under narrow bandwidth and high-power conditions. In the context of LEO satellite jamming scenarios, it improves the frequency-domain anti-jamming performance significantly and holds high application value for drone positioning.
Values-Based Education and the Promotion of Social Participation in Children’s Educational Leisure Organisations
Authors: Lazcano Quintana Idurre , Madariaga Ortuzar Aurora
Published: April 2024

As recent research has shown, the importance of integral development during childhood is a highly relevant issue linked to promoting values and participation styles in healthy and safe leisure environments, which serve as significant educational spaces for participants. Research shows that education in values is a foundation for citizens to commit to others and embrace diversity as a value and an enriching circumstance. In educational leisure spaces for children, personal and group identities are built around equity, justice, and inclusion, all of which generate greater social cohesion. The study universe of this work was made up of non-profit organisations working in the field of children’s educational leisure in the Basque Country, Catalonia, and Madrid. The methodology used was mixed and developed in three phases. The results presented here correspond to the first phase of the study (qualitative method) and focused on a content analysis, for which the categories of analysis related to education in values and the promotion of social participation were identified. Likewise, the results correspond to a specific territorial context, the historical territory of Bizkaia (northern Spain), specifically to ten non-profit organisations that develop their activity in the field of educational leisure time. The results have been organised around education in values, spaces and dynamics for social participation, and the vision of the sector’s future. The results highlight the entities’ role in methodological innovation, ethical commitment, the transmission of values, and the cultivation of participation from an early age through different activities. In conclusion, it emphasises the need for the children’s educational leisure sector to address the challenges of contemporary society.
Elementary Students’ Understanding about How Convex Lenses Affect Light Propagation
Authors: Kottara Aggeliki , Dimitrakou Maria , Starakis Ioannis
Published: April 2024

In the present study, K-3 and K-4 students’ understanding of the effects that convex lenses have on light propagation is investigated. Specifically, the study examines the extent to which these students are able to construct a scientifically accepted explanation for the role convex lenses play in converging rays of light and creating inverted images in the case of both self-luminous and hetero-luminous objects. Eight students from two primary schools run by the Municipality of Piraeus in the region of Attica (Greece), took part in the survey. They were divided into groups of two. The research was conducted using the teaching experiment method, which combines elements of the clinical interview and formal teaching. According to the results, students of this age recognise the convergence of light as a process that takes place through a convex lens. However, they have difficulty attributing the aforementioned convergence to the light refraction that takes place during the interaction of the light beams with the converging lens. At the same time, while they can easily ascertain that light beams continue along the same straight line after the convergence point, they find it difficult to relate this conclusion to the creation of an inverted image of a hetero-luminous object.
Does Private School Choice Threaten Democracy? Evidence from Private and Public Schools in New York City and Dallas/Fort Worth
Authors: Daniels Daion L. , Wolf Patrick J.
Published: April 2024

A major concern in the ongoing debate over school choice is whether private schools help to increase their students’ levels of tolerance necessary for a functioning democracy in the United States. Over 40 years ago, scholars at the University of Minnesota created a survey which measured political knowledge, political tolerance, perceived threats from opposing groups, and support for democratic norms anchored in each respondent’s view of the political group they find most distasteful. In 1997, researchers at various universities used a similar survey instrument to derive responses from students in eighth-grade social studies classes who were enrolled in seven public and twenty-four private schools in New York City and Dallas/Fort Worth, Texas. Those original data remained archived and unexamined for decades. We analyze those data using Ordinary Least Squares (OLS) and rigorous Nearest Neighbor Matching (NNM) methods based on propensity scores. We find that students who attended private schools demonstrate higher levels of political knowledge and stronger support for democratic norms when compared to observationally similar students who attended public schools.
The Relationship between Attitudes toward Death and Emotional Intelligence, Personality, Resilience, and Justice Beliefs: A Cross-Sectional Study of Midwives in Greece
Authors: Tzamakos Evangelos , Metallinou Dimitra , Sarantaki Antigoni , Tigka Maria , Lykeridou Aikaterini , Nanou Christina
Published: April 2024

Midwifery practice inevitably includes miscarriages, stillbirths, and neonatal deaths. The aim of the present study was to investigate the relationship between attitudes toward death and emotional intelligence, personality, resilience, and justice beliefs among midwives in Greece. A descriptive cross-sectional study was conducted from 2020 to 2022 among 348 midwives employed in public hospitals, in regional health authorities, or as independent professionals. Research instruments included the Death Attitude Profile—Revised, the Connor–Davidson Resilience Scale, the Trait Emotional Intelligence Questionnaire—Short Form, the Eysenck Personality Questionnaire, and the Belief in a Just World scale. The results revealed that greater emotional intelligence was significantly associated with higher scores in the escape acceptance subscale. Midwives scored low on the neutral acceptance subscale (2.9 ± 0.8), with the highest score being recorded in the escape acceptance subscale (4.6 ± 1.0), which was significantly associated with greater emotional intelligence. Neuroticism was significantly associated with the death avoidance, approach acceptance, fear of death, and escape acceptance subscales. Finally, the subscale of distributive justice beliefs for self and others was significantly associated with the subscales of death avoidance and approach acceptance. These findings highlight the nuanced perspectives within the healthcare community. As we delve deeper into the complexities of end-of-life care, understanding these diverse attitudes is crucial for providing comprehensive and empathetic support to both patients and healthcare professionals.