bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-Criteria Approach to Achieve Constrained Cost-Optimal Energy Retrofits of Buildings by Mitigating Climate Change and Urban Overheating
Authors: Ascione Fabrizio , Bianco Nicola , Mauro Gerardo Maria , Napolitano Davide Ferdinando , Vanoli Giuseppe Peter
Published: May 2018

About 40% of global energy consumption is due to buildings. For this reason, many countries have established strict limits with regard to building energy performance. In fact, the minimization of energy consumption and related polluting emissions is undertaken in the public perspective with the main aim of fighting climate change. On the other hand, it is crucial to achieve financial benefits and proper levels of thermal comfort, which are the principal aims of the private perspective. In this paper, a multi-objective multi-stage approach is proposed to optimize building energy design by addressing the aforementioned public and private aims. The first stage implements a genetic algorithm by coupling MATLAB® and EnergyPlus pursuing the minimization of energy demands for space conditioning and of discomfort hours. In the second stage, a smart exhaustive sampling is conducted under MATLAB® environment with the aim of finding constrained cost-optimal solutions that ensure a drastic reduction of global costs as well as of greenhouse gas (GHG) emissions. Furthermore, the impact of such solutions on heat emissions into the external environment is investigated because these emissions highly affect urban overheating, external human comfort and the livability of our cities. The main novelty of this approach is the possibility to properly conjugate the public perspective (minimization of GHG emissions) and the private one (minimization of global costs). The focus on the reduction of heat emissions, in addition to the assessment of energy demands and GHG emissions, is novel too for investigations concerning building energy efficiency. The approach is applied to optimize the retrofit of a reference building related to the Italian office stock of the 1970s.
Proctitis Caused by Mycobacterium avium-intracellulare in an HIV-Infected Patient
Authors: Gonzales Zamora Jose Armando , Milikowski Clara
Published: May 2018

Infectious proctitis is usually associated with sexually transmitted diseases, especially in HIV-infected individuals. Limited information is found about the role of Mycobacterium avium-intracellulare as a causative agent for this condition. Here, we report the case of an HIV-infected patient with a CD4 count of 304 cells/uL and undetectable HIV viral load, who presented with constipation and painful defecation. Endoscopic evaluation was significant for shallow rectal ulcerations. Histopathology revealed poorly formed granulomas. Stool culture grew Mycobacterium sp. that was further identified as Mycobacterium avium-intracellulare by DNA probe. He was successfully treated with a 3-drug regimen that included azithromycin, ethambutol and rifabutin. We advocate the use of AFB stool culture in cases of proctitis in which initial investigations for sexually transmitted diseases are unrevealing.
Robot Evaluation and Selection with Entropy-Based Combination Weighting and Cloud TODIM Approach
Authors: Wang Jing-Jing , Miao Zhong-Hua , Cui Feng-Bao , Liu Hu-Chen
Published: May 2018

Nowadays robots have been commonly adopted in various manufacturing industries to improve product quality and productivity. The selection of the best robot to suit a specific production setting is a difficult decision making task for manufacturers because of the increase in complexity and number of robot systems. In this paper, we explore two key issues of robot evaluation and selection: the representation of decision makers’ diversified assessments and the determination of the ranking of available robots. Specifically, a decision support model which utilizes cloud model and TODIM (an acronym in Portuguese of interactive and multiple criteria decision making) method is developed for the purpose of handling robot selection problems with hesitant linguistic information. Besides, we use an entropy-based combination weighting technique to estimate the weights of evaluation criteria. Finally, we illustrate the proposed cloud TODIM approach with a robot selection example for an automobile manufacturer, and further validate its effectiveness and benefits via a comparative analysis. The results show that the proposed robot selection model has some unique advantages, which is more realistic and flexible for robot selection under a complex and uncertain environment.
Quantum Trajectories: Real or Surreal?
Authors: Hiley Basil , Van Reeth Peter
Published: May 2018

The claim of Kocsis et al. to have experimentally determined “photon trajectories” calls for a re-examination of the meaning of “quantum trajectories”. We will review the arguments that have been assumed to have established that a trajectory has no meaning in the context of quantum mechanics. We show that the conclusion that the Bohm trajectories should be called “surreal” because they are at “variance with the actual observed track” of a particle is wrong as it is based on a false argument. We also present the results of a numerical investigation of a double Stern-Gerlach experiment which shows clearly the role of the spin within the Bohm formalism and discuss situations where the appearance of the quantum potential is open to direct experimental exploration.
Load Distribution of Semi-Central Evaporative Cooling Air-Conditioning System Based on the TRNSYS Platform
Authors: Li Ji , Liu Yuanwei , Zhang Ruixue , Liu Zhijian , Xu Wei , Qiao Biao , Feng Xiaomei
Published: May 2018

Evaporative cooling is a green, energy-efficient cooling technology adopted in hot and dry regions, which has wider application in the field of air-conditioning systems. Outdoor meteorological parameters have a great influence on the operation mode and control strategy of evaporative cooling air-conditioning systems, and the system load distribution and system configuration will be affected. This paper aims at investigating the load distribution of semi-central evaporative cooling air-conditioning systems under the condition of hourly outdoor meteorological parameters. Firstly, this paper introduced the design partition, operation mode, controlling strategy and load distribution method on semi-central evaporative cooling air-conditioning system. Then, taking an office building in Lanzhou (China) as an example, the evaporative cooling air-conditioning system was divided into five regions and the load distribution was simulated by TRNSYS (The Transient Energy System Simulation Tool) under the condition of hourly outdoor meteorological parameters. Finally, the results have shown that the evaporative cooling air-conditioning system can provide 25.46% of the building loads, which was of great significance to reduce the energy consumption of air-conditioning system.
Spatial Distribution of Biomass and Woody Litter for Bio-Energy in Biscay (Spain)
Authors: Mateos Esperanza , Ormaetxea Leyre
Published: May 2018

Forest management has been considered a subject of interest, because they act as carbon (C) sinks to mitigate CO 2 emissions and also as producers of woody litter (WL) for bio-energy. Overall, a sustainably managed system of forests and forest products contributes to carbon mitigation in a positive, stable way. With increasing demand for sustainable production, the need to effectively utilise site-based resources increases. The utilization of WL for bio-energy can help meet the need for renewable energy production. The objective of the present study was to investigate biomass production (including C sequestration) from the most representative forestry species (Pinus radiata D. Don and Ecualyptus globulus Labill) of Biscay (Spain). Data from the third and fourth Spanish Forest Inventories (NFI3-2005 and NFI4-2011) were used. We also estimated the potential WL produced in the forest activities. Our findings were as follows: Forests of Biscay stored 12.084 Tg of biomass (dry basis), with a mean of 147.34 Mg ha - 1 in 2005 and 14.509 Tg of biomass (dry basis), with a mean of 179.82 Mg ha - 1 in 2011. The total equivalent CO 2 in Biscay’s forests increased by 1.629 Tg year - 1 between 2005 and 2011. The study shows that the energy potential of carbon accumulated in the WL amounted to 1283.2 million MJ year - 1 . These results suggest a considerable potential for energy production.
Forest Biomass Policy in Minnesota: Supply Chain Perspectives on Barriers to Bioenergy Development
Authors: Carleton Laura Eaton , Becker Dennis
Published: May 2018

Forest biomass used for heating, electricity, and biofuel production is a source of energy that could reduce the dependence on energy imports while reinvesting domestically. Using the appropriate scale and technology, the US state of Minnesota is poised for increased forest bioenergy production due to the large existing forest products industry. Forest bioenergy investments have been slow to materialize despite state and federal incentives, and this research aims to determine what barriers there are to bioenergy development from the perspective of supply-chain actors by applying theories of natural resource governance. Findings from interviews include the need to create an equitable playing field in terms of energy subsidies and integrate forest bioenergy production with bio-based markets, including traditional forest product markets. Additionally, interviews indicate poor coordination and shared responsibility among state agencies, industry associations, and nonprofit organizations, resulting in a fragmented policy system. Principles to guide enabling forest bioenergy development are identified and discussed in the context of the study findings.
Kinetic Analysis of Freeze-Thaw Stability of Mayonnaise
Authors: Muhammad Shariful Islam , Katsuno Nakako , Nishizu Takahisa
Published: May 2018

Kinetic analysis was used to study the destabilization of mayonnaise by focusing on the fat crystals. Mayonnaise prepared from rapeseed oil and soybean oil was stored at temperatures ranging from −20 to −40 °C. The destabilization kinetic parameters were measured by observing oil separation over time. The destabilization rate constant, kd, increased with decreasing temperature. The highest value of kd was 1.28 × 10−3 min−1 at −40 °C for rapeseed oil mayonnaise (RoM) and the lowest was 1.95 × 10−6 min−1 at −20 °C for soybean oil mayonnaise (SoM). At each temperature, the kd value in RoM was higher than that in SoM. However, the order of destabilization, n, followed no specific pattern. The crystallization rate constant, Kc, and Avrami constant, n, were calculated using microscopic images of the fat crystals. The increase in crystallization kinetic parameters with decreasing temperature revealed changes in crystal behavior. Both the destabilization rate constant, kd, and the crystallization rate constant, Kc, depended on the temperature. This temperature dependency behavior showed a correlation between kd and Kc, suggesting that the destabilization rate depended on the rate of growth of fat crystals during the freeze-thawing of mayonnaise.
The Oncojanus Paradigm of Respiratory Complex I
Authors: Leone Giulia , Abla Houda , Gasparre Giuseppe , Porcelli Anna Maria , Iommarini Luisa
Published: May 2018

Mitochondrial respiratory function is now recognized as a pivotal player in all the aspects of cancer biology, from tumorigenesis to aggressiveness and chemotherapy resistance. Among the enzymes that compose the respiratory chain, by contributing to energy production, redox equilibrium and oxidative stress, complex I assumes a central role. Complex I defects may arise from mutations in mitochondrial or nuclear DNA, in both structural genes or assembly factors, from alteration of the expression levels of its subunits, or from drug exposure. Since cancer cells have a high-energy demand and require macromolecules for proliferation, it is not surprising that severe complex I defects, caused either by mutations or treatment with specific inhibitors, prevent tumor progression, while contributing to resistance to certain chemotherapeutic agents. On the other hand, enhanced oxidative stress due to mild complex I dysfunction drives an opposite phenotype, as it stimulates cancer cell proliferation and invasiveness. We here review the current knowledge on the contribution of respiratory complex I to cancer biology, highlighting the double-edged role of this metabolic enzyme in tumor progression, metastasis formation, and response to chemotherapy.
Variability of Shelf Growth Patterns along the Iberian Mediterranean Margin: Sediment Supply and Tectonic Influences
Authors: Durán Ruth , Lobo Francisco José , Ribó Marta , García Marga , Somoza Luis
Published: May 2018

Clinoform depositional features along the Iberian Mediterranean margin are investigated in this study, with the aim of establishing the causes of their varied shapes and other characteristics. We have analyzed the broad-scale margin physiography and seismic stratigraphic patterns based on high-resolution bathymetric data and previously interpreted seismic data. In addition, we have evaluated regional supply conditions and the uplift-subsidence regime of the different shelf sectors. The upper Quaternary record is strongly dominated by shelf-margin regressive wedges affected by the prevailing 100 ka cyclicity. However, the margins exhibit considerable lateral variability, as the result of the balance between the amount of sediment supply and the uplift-subsidence relationship. Three major shelf sectors with distinct morpho-sedimentary features have been defined. The relatively narrow northern shelves (Roses, La Planassa and Barcelona) are supplied by discrete river outlets that collectively constitute a linear source and are mainly affected by tectonic tilting. The wide middle shelves (Ebro Shelf, the Gulf of Valencia, and the Northern Arc) receive the sediment supply from the large Ebro River and other medium rivers. Although the tectonic regime changes laterally (strong subsidence in the north and uplift in the south), shelf growth is maintained by lateral advection of sediments. The southern shelves (the Southern Arc and the northern Alboran Shelf) are very abrupt and narrow because of the uplifting Betic Cordillera, and the torrential fluvial regimes that determine a very efficient sediment by-pass toward the deep basin. Submarine canyons deeply incised in the continental margin constitute a key physiographic feature that may enhance the transport of sediment to the deep sea or individualize shelf sectors with specific sedimentation patterns, as occurs in the Catalan margin.
Body Weight Misperception and Its Association with Unhealthy Eating Behaviors among Adolescents in China
Authors: Yan Hanyi , Wu Yingru , Oniffrey Theresa , Brinkley Jason , Zhang Rui , Zhang Xinge , Wang Yueqiao , Chen Guoxun , Li Rui , Moore Justin B.
Published: May 2018

This study aims to examine associations between body weight misperception and eating behaviors among Chinese adolescents. Students (N = 2641) from a middle school and a high school in Wuhan, China participated in a cross-sectional study in May 2016. A questionnaire based on the World Health Organization’s Global School-Based Student Health Survey was employed to assess responses. Self-reported data, including weight, height, body weight perception, and eating habits, were collected. Body Mass Index (BMI) for age z-score was calculated from self-reported height and weight using WHO AnthroPlus. We used descriptive, logistic regression analysis and a Kappa test to analyze the data using SPSS. Overall, 56.6% of participants did not correctly categorize their weight status; these were much more likely to be girls. Compared with the correctly-perceived group, those who underestimated their weight tended to report eating late at night, having dinners with family, and checking nutrition labels. In contrast, weight overestimating students were less likely to report eating late at night, having breakfasts with family, having dinners with family, and discussing nutrition topics over meals. Body weight misperception was associated with unhealthy eating behaviors among Chinese adolescents.
Understanding the Natural and Socioeconomic Factors behind Regional Longevity in Guangxi, China: Is the Centenarian Ratio a Good Enough Indicator for Assessing the Longevity Phenomenon?
Authors: Deng Qucheng , Wei Yongping , Zhao Yan , Han Xuerong , Yin Juan
Published: May 2018

Despite a number of longevity indicators having been used in previous longevity studies, few studies have critically evaluated whether these indicators are suitable to assess the regional longevity level. In addition, an increasing number of studies have attempted to determine the influence of socioeconomic and natural factors on regional longevity, but only certain factors were considered. This study aims to bridge this gap by determining the relationship between the 7 longevity indicators and selecting 24 natural and socioeconomic indicators in 109 selected counties and urban districts in Guangxi, China. This study has applied spatial analysis and geographically weighted regression as the main research methods. The seven longevity indicators here refer to centenarian ratio, longevity index, longevity level, aging tendency, 80+ ratio, 90+ ratio, and 95+ ratio. Natural indicators in this study mainly refer to atmospheric pressure, temperature, difference in temperature, humidity, rainfall, radiation, water vapor, and altitude. Socioeconomic indicators can be categorized into those related to economic status, education, local infrastructure, and health care facilities. The results show that natural factors such as the difference in temperature and altitude, along with socioeconomic factors such as GDP, might be the most significant contributors to the longevity of people aged 60–90 years in Guangxi. The longevity index and longevity level are useful supplementary indexes to the centenarian ratio for assessing the regional longevity.
Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice
Authors: Liang Danling , Yong Tianqiao , Chen Shaodan , Xie Yizhen , Chen Diling , Zhou Xinxin , Li Dan , Li Muxia , Su Lu , Zuo Dan
Published: May 2018

Searching novel hypouricemic agents of high efficacy and safety has attracted a great attention. Previously, we reported the hypouricemic effect of Ganoderma applanatum, but its bioactives, was not referred. Herein, we report the hypouricemic effect of 2,5-dihydroxyacetophenone (DHAP), a compound screened from Ganoderma applanatum computationally. Serum parameters, such as uric acid (SUA), xanthine oxidase (XOD) activity, blood urea nitrogen (BUN), and creatinine were recorded. Real-time reverse transcription PCR (RT-PCR) and Western blot were exploited to assay RNA and protein expressions of organic anion transporter 1 (OAT1), glucose transporter 9 (GLUT9), uric acid transporter 1 (URAT1), and gastrointestinal concentrative nucleoside transporter 2 (CNT2). DHAP at 20, 40, and 80 mg/kg exerted excellent hypouricemic action on hyperuricemic mice, reducing SUA from hyperuricemic control (407 ± 31 μmol/L, p < 0.01) to 180 ± 29, 144 ± 13, and 139 ± 31 μmol/L, respectively. In contrast to the renal toxic allopurinol, DHAP showed some kidney-protective effects. Moreover, its suppression on XOD activity, in vivo and in vitro, suggested that XOD inhibition may be a mechanism for its hypouricemic effect. Given this, its binding mode to XOD was explored by molecular docking and revealed that three hydrogen bonds may play key roles in its binding and orientation. It upregulated OAT1 and downregulated GLUT9, URAT1, and CNT2 too. In summary, its hypouricemic effect may be mediated by regulation of XOD, OAT1, GLUT9, URAT1, and CNT2.
Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells
Authors: Noro Erika , Yokoyama Atsushi , Kobayashi Makoto , Shimada Hiroki , Suzuki Susumu , Hosokawa Mari , Takehara Tomohiro , Parvin Rehana , Shima Hiroki , Igarashi Kazuhiko , Sugawara Akira
Published: May 2018

Aldosterone is synthesized in zona glomerulosa of adrenal cortex in response to angiotensin II. This stimulation transcriptionally induces expression of a series of steroidogenic genes such as HSD3B and CYP11B2 via NR4A (nuclear receptor subfamily 4 group A) nuclear receptors and ATF (activating transcription factor) family transcription factors. Nurr1 belongs to the NR4A family and is regarded as an orphan nuclear receptor. The physiological significance of Nurr1 in aldosterone production in adrenal cortex has been well studied. However, coregulators supporting the Nurr1 function still remain elusive. In this study, we performed RIME (rapid immunoprecipitation mass spectrometry of endogenous proteins), a recently developed endogenous coregulator purification method, in human adrenocortical H295R cells and identified PARP1 as one of the top Nurr1-interacting proteins. Nurr1-PARP1 interaction was verified by co-immunoprecipitation. In addition, both siRNA knockdown of PARP1 and treatment of AG14361, a specific PARP1 inhibitor suppressed the angiotensin II-mediated target gene induction in H295R cells. Furthermore, PARP1 inhibitor also suppressed the aldosterone secretion in response to the angiotensin II. Together, these results suggest PARP1 is a prime coregulator for Nurr1.
Degree of Left Renal Vein Compression Predicts Nutcracker Syndrome
Authors: Hangge Patrick T. , Gupta Nikhil , Khurana Aditya , Quencer Keith B. , Albadawi Hassan , Alzubaidi Sadeer J. , Knuttinen M-Grace , Naidu Sailendra G. , Oklu Rahmi
Published: May 2018

Nutcracker syndrome (NS) refers to symptomatic compression of the left renal vein (LRV) between the abdominal aorta and superior mesenteric artery with potential symptoms including hematuria, proteinuria, left flank pain, and renal venous hypertension. No consensus diagnostic criteria exist to guide endovascular treatment. We aimed to evaluate the specificity of LRV compression to NS symptoms through a retrospective study including 33 NS and 103 control patients. The size of the patent lumen at point of compression and normal portions of the LRV were measured for all patients. Multiple logistic regression analyses (MLR) assessing impact of compression, body mass index (BMI), age, and gender on the likelihood of each symptom with NS were obtained. NS patients presented most commonly with abdominal pain (72.7%), followed by hematuria (57.6%), proteinuria (39.4%), and left flank pain (30.3%). These symptoms were more commonly seen than in the control group at 10.6, 11.7, 6.8, and 1.9%, respectively. The degree of LRV compression for NS was 74.5% and 25.2% for controls (p < 0.0001). Higher compression led to more hematuria (p < 0.0013), abdominal pain (p < 0.006), and more proteinuria (p < 0.002). Furthermore, the average BMI of NS patients was 21.4 and 27.2 for controls (p < 0.001) and a low BMI led to more abdominal pain (p < 0.005). These results demonstrate a strong correlation between the degree of LRV compression on imaging in diagnosing NS.
Archetypes of Supply Chain Analytics Initiatives—An Exploratory Study
Authors: Herden Tino , Bunzel Steffen
Published: May 2018

While Big Data and Analytics are arguably rising stars of competitive advantage, their application is often presented and investigated as an overall approach. A plethora of methods and technologies combined with a variety of objectives creates a barrier for managers to decide how to act, while researchers investigating the impact of Analytics oftentimes neglect this complexity when generalizing their results. Based on a cluster analysis applied to 46 case studies of Supply Chain Analytics (SCA) we propose 6 archetypes of initiatives in SCA to provide orientation for managers as means to overcome barriers and build competitive advantage. Further, the derived archetypes present a distinction of SCA for researchers seeking to investigate the effects of SCA on organizational performance.
Influence of Powder Characteristics on Processability of AlSi12 Alloy Fabricated by Selective Laser Melting
Authors: Baitimerov Rustam , Lykov Pavel , Zherebtsov Dmitry , Radionova Ludmila , Shultc Alexey , Prashanth Konda Gokuldoss
Published: May 2018

Selective laser melting (SLM) is one of the additive manufacturing technologies that allows for the production of parts with complex shapes from either powder feedstock or from wires. Aluminum alloys have a great potential for use in SLM especially in automotive and aerospace fields. This paper studies the influence of starting powder characteristics on the processability of SLM fabricated AlSi12 alloy. Three different batches of gas atomized powders from different manufacturers were processed by SLM. The powders differ in particle size and its distribution, morphology and chemical composition. Cubic specimens (10 mm × 10 mm × 10 mm) were fabricated by SLM from the three different powder batches using optimized process parameters. The fabrication conditions were kept similar for the three powder batches. The influence of powder characteristics on porosity and microstructure of the obtained specimens were studied in detail. The SLM samples produced from the three different powder batches do not show any significant variations in their structural aspects. However, the microstructural aspects differ and the amount of porosity in these three specimens vary significantly. It shows that both the flowability of the powder and the apparent density have an influential role on the processability of AlSi12 SLM samples.
Optoelectronic Performance Variations in InGaN/GaN Multiple-Quantum-Well Light-Emitting Diodes: Effects of Potential Fluctuation
Authors: Islam Abu Bashar Mohammad Hamidul , Shim Jong-In , Shin Dong-Soo
Published: May 2018

We investigate the cause of the optoelectronic performance variations in InGaN/GaN multiple-quantum-well blue light-emitting diodes, using three different samples from an identical wafer grown on a c-plane sapphire substrate. Various macroscopic measurements have been conducted, revealing that with increasing strain in the quantum wells (QWs), the crystal quality improves with an increasing peak internal quantum efficiency while the droop becomes more severe. We propose to explain these variations using a model where the in-plane local potential fluctuation in QWs is considered. Our work is contrasted with prior works in that macroscopic measurements are utilized to find clues on the microscopic changes and their impacts on the device performances, which has been rarely attempted.
Facile Fabrication of Magnetic Metal-Organic Framework Composites for the Highly Selective Removal of Cationic Dyes
Authors: Li Huijun , Li Qingqing , He Yaling , Zhang Ning , Xu Zhouqing , Wang Yuan
Published: May 2018

In this work, we show a novel magnetic composite material Fe3O4@HPU-9 (HPU-9 = {[Cd(L)0.5(H2O)](DMA)(CH3CN)}n) (H4L = 1,1′-di(3,5-dicarbonylbenzyl)-2,2′bimidazoline, DMA = N,N-dimethylacetamide) constructed by in situ growth of HPU-9 on Fe3O4, which has excellent absorption of cationic dyes from aqueous solution. The Fe3O4@HPU-9 particle possesses a well-defined core-shell structure consisting of a Fe3O4 core (diameter: 190 nm) and a HPU-9 shell (thickness: 10 nm). In the composite, the HPU-9 shell contributes to the capsulation of cationic dyes through electrostatic attractions between HPU-9 and cationic dyes, while the Fe3O4 core serves as magnetic particle. The maximum absorption capacity of Fe3O4@HPU-9 for R6G was 362.318 mg·g−1. The absorption kinetics data were well described by a psedo-second-order model (R2 > 0.99), and the equilibrium data were also well fitted to Langmuir isotherm model (R2 > 0.99). Our data confirmed that the proposed magnetic composite could be recycled and reused several times without centrifugal separation, making it more convenient, economic and efficient than common adsorbents.
Fast Response and Spontaneous Alignment in Liquid Crystals Doped with 12-Hydroxystearic Acid Gelators
Authors: Lin Hui-Chi , Wang Chih-Hung , Wang Jyun-Kai , Tsai Sheng-Feng
Published: May 2018

The spontaneous vertical alignment of liquid crystals (LCs) in gelator (12-hydroxystearic acid)-doped LC cells was studied. Gelator-induced alignment can be used in both positive and negative LC cells. The electro-optical characteristics of the gelator-doped negative LC cell were similar to those of an LC cell that contained a vertically aligned (VA) host. The rise time of the gelator-doped LC cell was two orders of magnitude shorter than that of the VA host LC cell. The experimental results indicate that the gelator-induced vertical alignment of LC molecules occurred not only on the surface of the indium tin oxide (ITO) but also on the homogeneous alignment layer. Various LC alignments (planar, hybrid, multistable hybrid, and vertical alignments) were achieved by modulating the doped gelator concentrations. The multistable characteristic of LCs doped with the gelator is also presented. The alignment by doping with a gelator reduces the manufacturing costs and provides a means of fabricating fast-responding, flexible LC displays using a low-temperature process.
Synthesis and Mechanical Characterization of Binary and Ternary Intermetallic Alloys Based on Fe-Ti-Al by Resonant Ultrasound Vibrational Methods
Authors: Chanbi Daoud , Ogam Erick , Amara Sif Eddine , Fellah Z. E. A.
Published: May 2018

Precise but simple experimental and inverse methods allowing the recovery of mechanical material parameters are necessary for the exploration of materials with novel crystallographic structures and elastic properties, particularly for new materials and those existing only in theory. The alloys studied herein are of new atomic compositions. This paper reports an experimental study involving the synthesis and development of methods for the determination of the elastic properties of binary (Fe-Al, Fe-Ti and Ti-Al) and ternary (Fe-Ti-Al) intermetallic alloys with different concentrations of their individual constituents. The alloys studied were synthesized from high purity metals using an arc furnace with argon flow to ensure their uniformity and homogeneity. Precise but simple methods for the recovery of the elastic constants of the isotropic metals from resonant ultrasound vibration data were developed. These methods allowed the fine analysis of the relationships between the atomic concentration of a given constituent and the Young’s modulus or alloy density.
The Effect of Ultraviolet Radiation on Bitumen Aging Depth
Authors: Hu Jinxuan , Wu Shaopeng , Liu Quantao , García Hernández Maria Inmaculada , Zeng Wenbo , Nie Shuai , Wan Jiuming , Zhang Dong , Li Yuanyuan
Published: May 2018

The aging effect of ultraviolet (UV) radiation on bitumen has gained increasing attention from researchers, resulting in the emergence of a new method to simulate the UV aging that occurs during the service life of bitumen. However, the UV aging degree is closely related to bitumen thickness and the effect of UV radiation on aging depth is not clear. The relationship between ultraviolet (UV) radiation and bitumen UV aging depth was investigated in this paper. Three groups of samples were UV aged using different aging procedures to investigate the bitumen aging mechanism of UV radiation. The results from the first group showed that UV aging depth increased along with aging time. After aging for five hours, the complex modulus of the second and third layers increased. The second group’s results indicated that the aging effect of ozone was small and that the increase in aging depth was uncorrelated with ozone. The results from the third group showed that the transmittance of bitumen increased after UV aging and that the real reason why aging depth increased was permeation.
Fe3O4–Silicone Mixture as Flexible Actuator
Authors: Song Kahye , Cha Youngsu
Published: May 2018

In this study, we introduce Fe3O4-silicone flexible composite actuators fabricated by combining silicone and iron oxide particles. The actuators exploit the flexibility of silicone and the electric conductivity of iron oxide particles. These actuators are activated by electrostatic force using the properties of the metal particles. Herein, we investigate the characteristic changes in actuation performance by increasing the concentration of iron oxide from 1% to 20%. The developed flexible actuators exhibit a resonant frequency near 3 Hz and their actuation amplitudes increase with increasing input voltage. We found that the actuator can move well at metal particle concentrations >2.5%. We also studied the changes in actuation behavior, depending on the portion of the Fe3O4-silicone in the length. Overall, we experimentally analyzed the characteristics of the newly proposed metal particle-silicone composite actuators.
New Magnetostrictive Transducer Designs for Emerging Application Areas of NDE
Authors: Vinogradov Sergey , Cobb Adam , Fisher Jay
Published: May 2018

Magnetostrictive transduction has been widely utilized in nondestructive evaluation (NDE) applications, specifically for the generation and reception of guided waves for the long-range inspection of components such as pipes, vessels, and small tubes. Transverse-motion guided wave modes (e.g., torsional vibrations in pipes) are the most common choice for long-range inspection applications, because the wave motion is in the plane of the structure surface, and therefore does not couple well to the surrounding material. Magnetostrictive-based sensors for these wave modes using the Wiedemann effect have been available for several years. An alternative configuration of a sensor for generating and receiving these transverse-motion guided waves swaps the biasing and time-varying magnetic field directions. This alternative design is a reversed Wiedemann effect magnetostrictive transducer. These transducers exhibit a number of unique features compared with the more conventional Wiedemann sensor, including: (1) the use of smaller rare earth permanent magnets to achieve large, uniform, and self-sustained bias field strengths; (2) the use of more efficient electric coil arrangements to induce a stronger time-varying magnetic field for a given coil impedance; (3) beneficial non-linear operating characteristics, given the efficiency improvements in both magnetic fields; and (4) the ability to generate unidirectional guided waves when the field arrangement is combined with a magnetically soft ferromagnetic strip (patch). Reversed Wiedemann effect magnetostrictive transducers will be presented that are suitable for different inspection applications, one using electromagnetic generation and reception directly in a ferromagnetic material, and another design that integrates a magnetostrictive patch to improve its efficiency and enable special operating characteristics.
Macrophage Biocompatibility of CoCr Wear Particles Produced under Polarization in Hyaluronic Acid Aqueous Solution
Authors: Perez-Maceda Blanca Teresa , López-Fernández María Encarnación , Díaz Iván , Kavanaugh Aaron , Billi Fabrizio , Escudero María Lorenza , García-Alonso María Cristina , Lozano Rosa María
Published: May 2018

Macrophages are the main cells involved in inflammatory processes and in the primary response to debris derived from wear of implanted CoCr alloys. The biocompatibility of wear particles from a high carbon CoCr alloy produced under polarization in hyaluronic acid (HA) aqueous solution was evaluated in J774A.1 mouse macrophages cultures. Polarization was applied to mimic the electrical interactions observed in living tissues. Wear tests were performed in a pin-on-disk tribometer integrating an electrochemical cell in phosphate buffer solution (PBS) and in PBS supplemented with 3 g/L HA, an average concentration that is generally found in synovial fluid, used as lubricant solution. Wear particles produced in 3 g/L HA solution showed a higher biocompatibility in J774A.1 macrophages in comparison to those elicited by particles obtained in PBS. A considerable enhancement in macrophages biocompatibility in the presence of 3 g/L of HA was further observed by the application of polarization at potentials having current densities typical of injured tissues suggesting that polarization produces an effect on the surface of the metallic material that leads to the production of wear particles that seem to be macrophage-biocompatible and less cytotoxic. The results showed the convenience of considering the influence of the electric interactions in the chemical composition of debris detached from metallic surfaces under wear corrosion to get a better understanding of the biological effects caused by the wear products.
Expression of Cytokeratin 7 as a Histological Marker of Cholestasis and Stages of Primary Biliary Cirrhosis
Authors: Barakauskienė Aušrinė , Speičienė Danutė , Liakina Valentina , Semuchinienė Teresė , Valantinas Jonas
Published: May 2018

The aim of this study was to estimate cytokeratin 7 (CK-7) expression in biopsy specimens of patients with different stages of primary biliary cirrhosis and clinicopathological patterns (cholestatic and hepatitic) and its correlation with some biochemical and pathological parameters and to examine a diagnostic value of CK-7 expression.Material and Methods. A total of 82 biopsy specimens of patients with primary biliary cirrhosis were analyzed. CK-7 expression was graded by 4 grades depending on the extent into parenchymal areas and bile duct epithelium. The correlations of CK-7 expression grade with copper deposition, bile duct/portal tract ratio, bilirubin concentration, and activity of alkaline phosphatase and gamma-glutamyl transpeptidase were studied. CK-7 expression was evaluated as a marker of cholestasis (cholestatic pattern) and inflammation (hepatitic pattern). Results. A positive correlation of CK-7 expression grade with copper-binding protein grade (r=0.698, P<0.0001; OR=6.199, P<0.0001), serum bilirubin level (r=0.375, P=0.001), and alkaline phosphatase activity (r=0.276, P=0.014) was found. CK-7 expression grades correlated positively with histological stages of primary biliary cirrhosis (r=0.639, P<0.000) and negatively with granulomas (r=–0.432, P<0.0001; OR=0.173, P=0.0011). Conclusions. CK-7 expression is a sensitive marker of bile duct injury, which correlated well with histological stages of primary biliary cirrhosis, copper deposits, and biochemical markers of cholestasis: serum bilirubin level and alkaline phosphatase activity. Evaluation of CK-7 expression may improve the diagnosis of this serious and progressive disease. It is recommended to evaluate copper staining together with cytokeratin 7 expression in liver biopsy specimens for more precise diagnostic evaluation of asymptomatic primary biliary cirrhosis.
The Effect of Heating and Cooling on Time Course of Voluntary and Electrically Induced Muscle Force Variation
Authors: Brazaitis Marius , Skurvydas Albertas , Vadopalas Kazys , Daniusevičiūtė Laura , Senikienė Žibuoklė
Published: May 2018

The aim of this study was to investigate the effect of heating and cooling on time course of voluntary and electrically induced muscle force variation. Material and Methods. Ten volunteers performed 50 maximal voluntary and electrically induced contractions of the knee extensors at an angle of 120 degrees under the control conditions and after passive lower body heating and cooling in the control, heating, and cooling experiments. Peak torque, torque variation, and half-relaxation time were assessed during the exercise. Results. Passive lower body heating increased muscle and core temperatures, while cooling lowered muscle temperature, but did not affect core temperature. We observed significantly lower muscle fatigue during voluntary contraction compared with electrically induced contractions. Body heating (opposite to cooling) increased involuntarily induced muscle force, but caused greater electrically induced muscle fatigue. In the middle of the exercise, the coefficient of correlation for electrically induced muscle torque decreased significantly as compared with the beginning of the exercise, while during maximal voluntary contractions, this relation for torque remained significant until the end of the exercise. Conclusion. It was shown that time course of voluntary contraction was more stable than in electrically induced contractions.
The Comparison of Different Surgical Techniques Used for Repair of Complete Unilateral Cleft Lip
Authors: Zaleckas Linas , Linkevičienė Laura , Olekas Juozas , Kutra Nerijus
Published: May 2018

Up to now, many various techniques have been proposed for the repair of complete unilateral cleft lip. The aim of this study was to compare late results of three different surgical techniques (C. Tennison, R. Millard, and J. Olekas) used for the repair of complete unilateral cleft lip and to analyze their advantages and disadvantages. Material and Methods. Sixty-six patients with nonsyndromic complete unilateral cleft lip, alveolus, and palate were examined. For 19 patients (28.8%), cleft lip repair was performed using the Tennison technique; for 20 patients (30.3%), Millard technique; and for 27 patients (40.9%), Olekas technique. Results were assessed by score, which was given by analyzing standardized photographs of nasolabial triangles. For the assessment, the modified scale according to Mortier and Anastassov was used. Separate anatomical elements – red lip, white lip, scars, and nose – were assessed. Results. The best appearance of the red lip and white lip was found after the Tennison technique. Scars and nose looked the best after Olekas cheiloplasty. There were no significant differences in the evaluation of red lip and nose appearance comparing all three analyzed surgical techniques (P>0.05). Tennison technique showed significantly better results in the appearance of the white lip (P<0.05); the appearance of scars was significantly better after the Olekas repair (P<0.001). Conclusions. Height of white lip and symmetry of the Cupid’s bow were better restored by using the Tennison technique. The physiological configuration of the white lip and less visible scars were achieved by using the Olekas technique. All techniques were equal in red lip and nose formations.
Activity of Neutrophil β-Glucuronidase in Diabetic and Nondiabetic Patients With Chronic Generalized Periodontitis and Healthy Subjects
Authors: Šurna Algimantas , Sakalauskienė Jurgina , Gleiznys Alvydas , Ivanauskienė Eglė , Šaferis Viktoras
Published: May 2018

Objective. The aim of the study was to establish the dynamics of β-glucuronidase activity in subjects suffering from type 1 diabetes and chronic untreated generalized periodontitis, subjects suffering from chronic untreated generalized periodontitis only, and control subjects not suffering from generic diseases with healthy periodontal tissue. Material and Methods. The study involved 165 19–50-year-old subjects who were divided into three groups: healthy subjects (n=55), subjects with chronic untreated generalized periodontitis (n=55), and subjects with type 1 diabetes and chronic untreated generalized periodontitis (n=55). Neutrophilic leukocytes of peripheral venous blood were exposed to bacterial stimuli: opsonized zymosan, nonopsonized Staphylococcus aureus, and prodigiosan. The activity of β-glucuronidase was determined by the spectrofluorimetry method. Results. The diagnostic value of changes in β-glucuronidase activity of neutrophilic leukocytes markedly increased in all study groups after stimulation of neutrophilic leukocytes by opsonized zymosan, nonopsonized Staphylococcus aureus, and prodigiosan as compared to control media not exposed to any stimulus (P<0.001). The strongest relationship (canonical correlation coefficient eta, 0.993) between the intensity of periodontal pathology markers and the activity of β-glucuronidase of neutrophilic leukocytes in incubated media in patients with type 1 diabetes mellitus and periodontitis was found under the effect of nonopsonized Staphylococcus aureus. Conclusions. If periodontal impairment is severe, diabetes mellitus possibly causes a faster destruction of the periodontal tissue and presents a higher risk of periodontitis for patients with diabetes.
Factors Related to Gender Differences in Toothbrushin g Among Lithuanian Middle-Aged University Employees
Authors: Sakalauskienė Žana , Vehkalahti Miira , Murtomaa Heikki , Mačiulskienė Vita
Published: May 2018

Background and objectives. Many previous studies showed clear gender differences in the percentages of adults reporting toothbrushing more than once a day. This study evaluated the factors determining gender differences in toothbrushing among Lithuanian middle-aged university employees. Material and Methods. A questionnaire survey was anonymously conducted among 35- to 44-year-old employees (n=862) of four universities in Lithuania in 2005. The response rate was 64% (n=553). Data covered toothbrushing frequency, habitual dental attendance, dental health attitudes and knowledge, and subject’s background information. Results. Of all respondents, 68% reported brushing their teeth more than once a day (73% of women and 49% of men, P<0.001) and 51% indicated checkup-based habitual dental attendance (54% of women and 41% of men, P=0.012). The majority reported good dental status as being important to them and poor oral health as injurious to general health. Of all respondents, 44% indicated that “Lack of time is the main reason for incomplete oral self-care” (61% of men and 40% of women, P<0.001). Logistic regression models showed that the strongest factor affecting toothbrushing frequency was the importance of good dental health to them (OR, 1.6; 95% CI, 1.1–2.4; P=0.02) among women and statement that “Poor oral health can be injurious to general health” (OR, 2.6; 95% CI, 1.2–5.5; P=0.01) and checkup-based habitual dental attendance (OR, 2.4; 95% CI, 1.0–5.9; P=0.06) among men. Conclusions. Due to different determinants affecting toothbrushing frequency among men and women, different oral health motivation programs by gender should be developed.
Tuberkuliozės prevencijos ir gydymo rekomendacijos skiriant naviko nekrozės faktoriaus alfa blokatorius (Lietuvos pulmonologų ir reumatologų sutarimas)
Authors: Malakauskas Kęstutis , Zablockis Rolandas , Venalis Algirdas , Butrimienė Irena , Baranauskaitė Asta , Nargėla Remigijus , Sakalauskas Raimundas
Published: May 2018

Pacientai, sergantys reumatinėmis ligomis (reumatoidiniu, psoriaziniu artritu, ankilozuojančiu spondilitu) ir vartojantys naviko nekrozės faktoriaus alfa blokatorius (TNF-α), turi didesnę tuberkuliozės riziką. Tuberkuliozės prevencijos ir gydymo rekomendacijos, prieš skiriant TNF-α blokatorius, parengtos atsižvelgus į didelį tuberkuliozės paplitimą, didelį Mycobacterium tuberculosis atsparumą vaistams, visuotinę Bacillus Calmette-Guérin vakcinaciją nuo tuberkuliozės Lietuvoje. Siekiant sumažinti tuberkuliozės riziką, būtinas paciento ištyrimas prieš pradedant gydymą TNF-α blokatoriumi. Tuo tikslu atliekamas išsamus klinikinis ir dviejų krypčių krūtinės ląstos rentgenologinis tyrimas. Tuberkulino odos mėginys pagal Mantoux metodiką naudojant penkis tuberkulino vienetus arba gama interferono išskyrimo mėginys atliekami pacientams, kuriems nėra radiologinių potuberkuliozinių pokyčių. Jei, tiriant radiologiškai, randamas Gono kompleksas, liekamieji negydytos tuberkuliozės pokyčiai, arba Mantoux, arba gama interferono išskyrimo mėginys yra teigiamas, pacientui skiriamas latentinės tuberkuliozės gydymas. Taigi, latentinės tuberkuliozės gydymui skiriamas izoniazido ir rifampicino 3 mėn. kursas, o gydymas naviko nekrozės faktoriaus alfa blokatoriumi pradedamas ne anksčiau kaip 1 mėn. nuo latentinės tuberkuliozės gydymo pradžios. Įtariant aktyvią Mycobacterium tuberculosis infekciją, tuberkuliozė diagnozuojama mikrobiologiškai arba morfologiškai ir skiriamas prieštuberkuliozinis gydymas.