bluuebunny/crossref_metadata_2025 huggingface dataset:
Assistência médica humanizada na graduação: uma revisão integrativa de literatura
Authors: Giraldes Juliana Marques , Silva Rose Mary  Costa Rosa Andrade , Pereira Eliane Ramos
Published: August 2022

A prática médica, atualmente, é pautada, majoritariamente, em ciência e tecnologia, pesquisas científicas e descobertas. Quando se fala em humanização, principalmente durante a graduação, o estudante acaba se distanciando, preferindo o aperfeiçoamento em disciplinas que visam, apenas, conteúdos de formação prática. Nesse caminho, este artigo objetivou evidenciar o conceito sobre assistência humanizada na prática médica descrito na literatura nacional e internacional. Realizou-se uma revisão integrativa em três bases de dados, com os descritores “Humanization of Assistance”, “Student Medical” e “Medicine”, perfazendo uma amostra final de 13 artigos. O conceito de humanização está relacionando a aspectos biopsicossociais e é fundamental para a construção de uma prática clínica eficaz. O exercício da humanização durante o curso de Medicina é dificilmente visto ao longo da formação acadêmica como essencialmente deveria ser vivenciado através das disciplinas obrigatórias. Além disso, disciplinas voltadas para o desenvolvimento de uma reflexão acerca do indivíduo em sua totalidade de ser é o grande desafio em um século caracterizado por grandes descobertas e elevado desenvolvimento tecnológico. A produção científica demonstra que disciplinas voltadas para a temática da Humanização são consideradas menos relevantes para os estudantes de Medicina, apesar das evidências de seus benefícios para uma formação mais sensível e completa. A formação médica necessita de estratégias que possam vincular a área de humanidades às áreas biológicas. Grande é o desafio em resgatar o conceito de humanização do cuidado diante de um cenário caracterizado por tecnologia e protocolos que visam o processo saúde-doença, distanciando-se do humano, o que verdadeiramente importa.
Perfil de equilíbrio e de freezing de idosos com doença de Parkinson assistidos no município de João Pessoa – PB
Authors: Antas Bárbarah Carolyne Moreira Rodrigues , Galdino Ramayana Rubiane , Carneiro Amanda do Nascimento Oliveira , Calado Vitória Ferreira , Férrer Mayane Laís Veloso , Clementino Adriana Carla Costa Ribeiro
Published: August 2022

Objetivo: Analisar e descrever os aspectos clínicos e as condições sociodemográficas de indivíduos com Doença de Parkinson (DP) e acompanhamento clínico na grande João Pessoa. Metodologia: Estudo descritivo desenvolvido com 30 sujeitos de ambos os sexos, com idade entre 40 e 80 anos, diagnosticados com DP idiopática em todos os estágios da escala de Hoehn e Yahr Modificada (H&YM). A avaliação ocorreu por um questionário semiestruturado, testes de cognição e mobilidade funcional. Resultados: A média de idade encontrada foi 60,47 ± 7,57 anos, sendo 71,3% homens, residentes na zona urbana e renda salarial média de 2 a 3 salários mínimos. O tempo de diagnóstico relatado foi de 82,5 ± 69,1 meses predominando o subtipo clínico misto. A média calculada no MEEM foi de 26,7 pontos. Os participantes apresentaram alterações motoras relacionadas à disfunção de marcha, alegando congelamento e um expressivo número de quedas. Os sintomas não-motores mais frequentes foram: Distúrbios do sono (56,7%), distúrbios cardiovasculares (36,7%) e distúrbios gastrointestinais (16,7%). Conclusão: Embasado nos resultados deste estudo, constatou-se que o perfil sociodemográfico predominante é de indivíduos de meia idade, casado e do sexo masculino, classificados entre os estágios II e III da DP, média de tempo de diagnóstico de 6 anos e subtipo clínico misto. O nível social e cognitivo condiz com a escolaridade da amostra. Observou-se presença de alterações motoras importantes relacionadas à disfunção de marcha, além de sintomas não-motores da DP.
Análise bibliográfica dos impactos na qualidade de vida de pacientes diabéticos com amputações de membros
Authors: Sousa Maria Helena Pinto , Ramos Surama Michele do Nascimento , Santos Samara Maria dos , Carvalho Sâmira Naiara de Sousa , Lima Jessika Cristielle dos Santos , Oliveira Luan Mirellyson de , Santos Lídia Resplandes Gomes , Sousa Karen Laís Azevedo Oliveira , Ramos Samia Daniele do Nascimento , Santos Márcia Sousa
Published: August 2022

O Diabetes Mellitus é uma doença metabólica não transmissível bastante comum, tem origem multifatorial e é caracterizada pela elevação dos níveis glicêmicos por conta da ausência ou incapacidade da insulina de fazer sua função fisiológica, acarretando várias complicações e disfunções de órgãos, o objetivo geral do estudo foi analisar na Literatura os impactos na qualidade de vida de portadores de Diabetes Mellitus com amputação de membros. Trata-se de uma pesquisa bibliográfica do tipo revisão integrativa da literatura, onde o método foi escolhido por ter como finalidade sintetizar resultados obtidos em pesquisas de maneira sistemática, ordenada e abrangente, mediante diferentes metodologias. Quanto aos resultados, observou-se que as condições físicas dos pacientes contribuem para o aparecimento de outras patologias, como depressão e ansiedade, o que significa que esses pacientes antes e depois da cirurgia devem passar por um psicólogo. Conclui-se que o estudo permitiu identificar o perfil epidemiológico, os impactos e sentimentos de pacientes com diabetes mellitus que sofreram amputação de membros, onde indivíduos do sexo masculino com baixa escolaridade, baixa condição econômica e moradores de áreas carentes que se encontram em situação de vulnerabilidade tinham risco aumentado para essa complicação. Constatou-se que há falhas no sistema primário de saúde, em que esses profissionais devem ter um cuidado maior na avaliação desses pacientes, incluindo a necessidade de repassar orientações sobre o quão fundamental é a prática do autocuidado.
Efeito da fototerapia laser na percepção álgica, no medo do movimento e na qualidade de vida de sujeitos com dor miofascial associada à fibromialgia
Authors: Rodrigues Layana Fontes de Brito , Silva Amanda Feitoza da , Bonjardim Leonardo Rigoldi , Santana Josimari Melo de , Macieira José Caetano , Ribeiro Maria Amália Gonzaga , Aciole Gilberth Tadeu dos Santos , Pinheiro Antônio Luiz Barbosa , Araujo Fernanda Santos , Moreira Thalwylla Reiler Morato dos Reis
Published: August 2022

O estudo avaliou a eficácia da fototerapia laser no ponto gatilho miofascial do músculo trapézio em pacientes fibromiálgicos. 25 indivíduos foram diagnosticados com dor miofascial e fibromialgia e divididos em grupos: Laser (n=8), Laser + medicamento (n=10) e Medicamento (n=7) e tratados durante 5 semanas. As variáveis mensuradas foram: 1) Intensidade da dor pela Escala Visual Analógica (EVA); 2) Limiar de dor à pressão (LDP) por meio de algômetro de pressão; 3) Estado geral da dor por meio do Questionário de Rolland-Morris (QIRM); 4) Medo de movimentar pela Escala de Tampa para Cinesiofobia (ETC) e 5) Avaliação do impacto da Fibromialgia na qualidade de vida (QIF). Os dados obtidos foram analisados por meio da análise de variância (ANOVA) de duas vias para medidas repetidas, seguida pelo pós-teste de Tukey, quando apropriado. Para os casos em que a interação entre os fatores (Tratamento e Tempo) foi significativa, foi conduzida ANOVA para medidas repetidas de uma via para cada grupo de tratamento. Todos os testes foram bi-caudais e foi considerado p<0,05. Verificou-se diminuição da intensidade da dor e aumento do LDP no músculo trapézio superior na 5ª e 10ª sessões em relação ao basal para os grupos em que a fototerapia foi utilizada. Não houve interação significativa entre os escores das variáveis QIRM, ETC e QIF entre os grupos. A escala QIF, rigidez e ansiedade, mostraram diferença significativa entre os grupos. A fototerapia laser promoveu uma diminuição da intensidade da dor local e um aumento do LDP do músculo trapézio.
Avaliação do estado nutricional e consumo alimentar de pacientes com depressão
Authors: Barros Anael Queirós Silva , Albuquerque Luciana Martins , Lourenço Maria Leilah Monte Coelho , Fernandes Mariane  Silveira Magalhães , Fontenele Yara Edwirges de Albuquerque , Sampaio Helena Alves de Carvalho
Published: August 2022

Avaliar se há associação entre o estado nutricional e o consumo alimentar de pacientes com depressão. O estudo foi desenvolvido no Centro de Atenção Psicossocial (CAPS), localizado na cidade de Sobral - CE, com 100 pacientes com transtorno depressivo, na faixa etária entre 20 e 59 anos, ambos os sexos. Foram coletados dados socioeconômicos, antropométricos, e o consumo alimentar através de um Questionário de Frequência Alimentar (QFA). O projeto foi aprovado pelo Comitê de Ética em Pesquisa, sob parecer nº 2.596.743. Dos 100 participantes da amostra, 67% (n= 67) foram mulheres, na faixa etária “menor que 39 anos”, 55% (n= 55), a cor negra 51% (n = 51), a união consensual∕casado 56% (n= 56) e a renda de até um salário mínimo 55% (n=55). Ao analisarmos o estado nutricional, ambos os sexos, apresentaram um número maior de participantes com sobrepeso e obesidade. A prevalência de excesso de peso foi de 89%, sendo 58% do sexo feminino e 31% do sexo masculino. Quanto ao consumo alimentar não houve diferença entre os participantes, segundo o Índice de Massa Corpórea (IMC) (p > 0,05). Há alta proporção de excesso de peso entre os pacientes avaliados e este não foi associado ao consumo alimentar.
Uma ideologia construída: representações femininas na revista Illustração Pelotense no início do século XX
Authors: Miranda Ágata Hax , Rostas Márcia Helena Sauaia Guimarães
Published: August 2022

O presente artigo visa perceber a mulher, enquanto um sujeito histórico e social, que se constitui a partir da ideologia e da cultura impostas por uma sociedade classista. O objetivo principal é analisar a ideologia disseminada na Revista Illustração Pelotense, no início do século XX, sob a ótica nas informações destinadas ao público feminino, através da imprensa. O tema emergente foi o trabalho doméstico, o qual discutimos em três tópicos. No primeiro, abordamos a naturalização do trabalho doméstico à mulher na sociedade capitalista, através da imprensa, assim, a percebemos sendo educada, desde a infância, para cumprir com rigor seu papel de esposa, mãe e doméstica. Ainda, percebemos a discriminação de classes, uma vez que os enunciados apontavam à subjugação do trabalho doméstico das mulheres da elite às das classes subalternas, bem como a depreciação desses corpos.  Na sequência, discorremos sobre a educação feminina voltada à submissão e à subserviência como um ato de amor. No último tópico, discutimos sobre a discriminação racial, através da percepção do apagamento da mulher negra na revista, assim, compreendemos que, mesmo após alforriada, ela se manteve excluída, ocupando os lugares sociais e profissionais de menor prestígio. Ao final da análise, observamos a imprensa pelotense à época agindo por meio dos marcadores de discriminação de sexo, raça e classe na sociedade capitalista.
Keban (Elazığ) Cadde Sokak Sistemlerinin Mekân Dizim Analizi Yöntemiyle İncelenmesi
Authors: ŞIKOĞLU Emrah
Published: August 2022

Tarihsel süreç içerisinde uzun zaman önemini koruyan Keban yerleşmesinin dokusu topografik etmenler tarafından yönlendirilmiştir. Dokuya karakterini kazandıran fiziksel öğelerin yanı sıra insanların mekânda daha kolay dolaşmalarını sağlamak için kullandığı çözümler, yerleşmeye farklı bir topolojik özellik kazandırmıştır. Çalışmada Keban yerleşme dokusunun topolojik çözümlemesi yapılmıştır. Çözümleme yapılırken kent morfolojisindeki cadde ve sokakların hiyerarşik yapısını tespit etmek için Mekân Dizim Analizi yöntemi kullanılmıştır. Böylece yerleşmenin kendine özgü dokusu mekânsal bütünleşme ve entegrasyon yönünden değerlendirilmiştir. Özellikle yayaların yerleşme içinde daha kolay ulaşımını sağlayan merdivenlerin yerleşmenin entegrasyonu ve bütünleşmesi üzerindeki önemi üzerinde durulmuştur. Bu ölçekte yerleşmenin yol dokusunda iki temel analiz yapılmıştır. Bunlardan biri bütün sistemleri içerirken, diğerinde merdivenler sistemden çıkarılarak analiz edilmiştir. Her iki simülasyon karşılaştırılarak, merdivenlerin doku işleyişi üzerindeki önemi tartışılmıştır. Sonuç olarak elde edilen verilerle topografyanın elverdiği ölçüde gelişen ulaşım sistemi üzerinde merdivenlerin entegrasyondaki önemi tespit edilmiştir.
DETERMİNATION OF SOME ANTIOXIDANT ENZYME LEVELS IN HAIRDRESSER EMPLOYESS IN THE CENTRAL DISTRICTS OF VAN PROVİNCE
Authors: YILDIZ Halime , DEMİR Canan , GÜR Tuğba , YÜREKTÜRK Şehriban , TEKELİ Arzu Esen
Published: August 2022

Although hairdressing is not a dangerous profession, it is known that hairdressers are exposed to chemical combinations known as allergens, carcinogens or organic solvents. In this study, it was aimed to determine the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH), which are known as some important antioxidants, and malondialdehyde (MDA), the end product of lipid peroxidation and an indicator of oxidative stress, in hairdresser workers in Van. 33 female hairdresser employees working in the central districts of Van (Edremit, Tusba and Ipekyolu) were included in the scope of the study as subjects, and voluntary participants using hairdresser services were included as the control group. Venous blood was taken from those who accepted the study, examined in the laboratory, and the results were statistically analyzed. The difference between group means for MDA, CAT, SOD and GSH was statistically significant (p<0.05). As a result, it can be said that hairdressers, whose professional lives will last for many years, are in the potential risk group in the formation of diseases such as eczema, asthma, cardiovascular diseases, cancer, in which reactive oxygen derivatives also play a role, since they are constantly exposed to physical and chemical factors.
A sanctuary built on conflict
Authors: Ekelund Robin
Published: August 2022

This article investigates conflicts in retrospective Facebook groups, i.e., groups created with a particular interest and focus on the past, to analyse how members of these groups understand the past and how they negotiate, resist and challenge each other’s notions of the past. The data comes from a netnographic fieldwork within six such retrospective groups. Theoretical inspiration is drawn from Actor-Network-Theory (Harrison 2013, Latour 2005). The analysis thusly focuses on human (the members of the groups) as well as non-human actors (the operative logic of Facebook) and study how these produce associations between the past and the present. An overall result of the study is that the retrospective Facebook groups are not characterised by conflict. Instead, they are produced as places of sanctuary, where associations with the past becomes a basis for a nostalgic feel-good culture. However, the analysis also shows that the sanctuaries build on the production of a discontinuity and a conflict between the past and the present. Using Boym’s concept of ruinophilia, as well as Bauman’s concept of retrotopia, the article discusses how the conflicted discontinuity between the past and the present produces an us-and-them relationship where group members can come together in a nostalgic as well as a critical care for the world as it (in their perspectives) was supposed to be. The analysis also illustrates how members’ use of sources and references becomes a mere stylistic performance of authority, as the operative logic of Facebook not only enables but also constrains group interactions, reducing the members’ possibilities of having profound interactions and negotiations based on their memories and notions of the past. The article hereby contributes to the emerging research on digital memories in general, and memory work on Facebook in particular.
The Challenge of the Heritage of Protest Movements
Authors: Manikowska Ewa
Published: August 2022

This article analyses the challenge of collecting the heritage of present-day global protest movements, which are shaped and influenced by digital practices. In focus of the analysis are the mass-street demonstrations which took place in cities all over Poland in 2020 and 2021 to denounce the ruling of the Constitutional Tribunal imposing a near-total ban on abortion (the “women’s rebellion”). Considered as the largest social protests since the fall of communism in 1989, they have engendered several spontaneous documenting and collecting initiatives. The aims and outcomes of such projects, launched by Polish museums, NGOs, artistic collectives, etc. will be juxtaposed in this article with similar ventures aimed at collecting and archiving the global social movements of the twenty first century and examined as the first Polish examples of Rapid Response Collecting (RRC). This article, by analysing the recent RRC projects of the 2020/21 protests against the abortion ban in Poland, aims to inscribe them in the current discussions on the preservation of digital heritage. While pointing out definitional issues with digital heritage, my analysis also demonstrates the need to integrate and interrelate digital heritage within the wider framework of cultural heritage, its preservation and institutionalisation.
Between Words and Silence
Authors: Golonka-Czajkowska Monika , Trebunia-Staszel Stanisława
Published: August 2022

This article tackles the risks of digitization of sensitive collections and the ethical limits of open access. Research into experience of conflicts and violence requires the submerging into a world of local taboos and practices that usually remain within the sphere of cultural intimacy. Similarly, the digitization of sensitive collections can grant an un-curated uncontrolled access to realms which should be handled with ethical awareness and sensitivity. We focus on two case-studies referring to the Podhale, a region in the Tatra Mountains inhabited by local people called Górale. The first one is the archive of Nazi anthropological photography and documentation recently rediscovered at the Smithsonian Institution Archives (SIA). Its digitization in 2007 marked the start of a research project on WWII anthropology in Podhale, evoking at the same time an ardent and emotional debate among both scholars and the Górale community. The most serious issues referred to the impact of the digitized photographs on the present-day collective memory of the Górale. In fact, till the archive’s discovery and digitization, the episode of Nazi racial research was literally cast out from local history and memory. In this article we will ask how to deal with such materials and conduct research among people, for whom such documentation invokes unwanted and traumatic experiences. The second case-study focuses on contemporary memory conflicts related to the anti-communist guerrilla group “B?yskawica” (Lightning) operating in the aftermath of WWII on the Polish-Slovak border in the Tatra Mountains region. Accused by communist authorities of war-crimes, these partisans were officially rehabilitated only in the aftermath of the Polish Revolution of 1989. Memories about “B?yskawica” are still very vivid in this region evoking conflicting feelings from undisputed glorification to total condemnation. This article will inquire into the ambiguous digital discourses in the social media around such conflicting memories build on digitized resources from the archives of the former secret police (now deposited at the Institute of National Remembrance; INR - Institut Pami?ci Narodowej, IPN ). Both case-studies deal with a similar period, region, type of sources (archives produced in the past by the regime’s institutions of power). Both refer to the memory of experiences of violence, difficult choices, local conflicts, oppressive regimes and practices. We argue that the transition of such sensitive data into the digital realm raises the danger of manipulation by various interest groups, arbitrary defragmentation and reconfiguration. It can enliven and even reinforce old conflicts, generate new ones and even undermine the fragile social and cultural balance within a community.
Surgical Fixation of Calcaneal Beak Fractures—Biomechanical Analysis of Different Osteosynthesis Techniques
Authors: Jordan Martin C. , Hufnagel Lukas , McDonogh Miriam , Paul Mila M. , Schmalzl Jonas , Kupczyk Eva , Jansen Hendrik , Heilig Philipp , Meffert Rainer H. , Hoelscher-Doht Stefanie
Published: August 2022

The calcaneal beak fracture is a rare avulsion fracture of the tuber calcanei characterized by a solid bony fragment at the Achilles tendon insertion. Treatment usually requires osteosynthesis. However, lack of biomechanical understanding of the ideal fixation technique persists. A beak fracture was simulated in synthetic bones and assigned to five different groups of fixation: A) 6.5-mm partial threaded cannulated screws, B) 4.0-mm partial threaded cannulated screws, C) 5.0-mm headless cannulated compression screws, D) 2.3-mm locking plate, and E) 2.8-mm locking plate. Different traction force levels were applied through an Achilles tendon surrogate in a material-testing machine on all stabilized synthetic bones. Outcome measures were peak-to-peak displacement, total displacement, plastic deformation, stiffness, visual-fracture-line displacement, and mode of implant failure. The 2.3- and 2.8-mm plating groups showed a high drop-out rate at 100 N tension force and failed under higher tension levels of 200 N. The fracture fixation using 4.0-mm partial threaded screws showed a significantly higher repair strength and was able to withhold cyclic loading up to 300 N. The lowest peak-to-peak displacement and the highest load-to-failure and stiffness were provided by fracture fixation using 6.5-mm partial threaded cannulated screws or 5.0-mm headless cannulated compression screws. As anticipated, large 6.5-mm screw diameters provide the best biomechanical fixation. Surprisingly, the 5.0-mm headless cannulated compression screws yield reliable stability despite the absent screw head and washer. When such large screws cannot be applied, 4.0-mm screws also allow reasonable fixation strength. Plate fixation should be implemented with precaution and in combination with a restrictive postoperative motion protocol. Finally, clinical cases about the surgical application and recovery are included.
Improvement of the bladder perfusion curative effect through tight junction protein degradation induced by magnetic temperature-sensitive hydrogels
Authors: Sun Xiaoliang , Song Xinhong , Guo Peng , Zhang Dong , Zuo Shishuai , Leng Kang , Liu Yun , Zhang Haiyang
Published: August 2022

Postoperative intravesical instillation of chemotherapy is a routine procedure for non-muscular invasive bladder cancer (NMIBC). However, traditional bladder perfusion methods have insufficient exposure time, resulting in unsatisfactory therapeutic effects. In the present study, a chitosan (CS)-based in situ forming depot (ISFD) delivery system, including Fe3O4 magnetic nanoparticles (Fe3O4-MNP), CS, and β-glycerophosphate (GP) as main components, was synthesized. Pirarubicin (THP), as a chemotherapeutic drug, was loaded into the new system. Results showed that our carrier system (Fe3O4-THP-CS/GP) was converted into gel and attached to the bladder wall, possessing loose network structures with magnetic targeting and sustained release properties. Moreover, its retention time in bladder was more than 72 h accompanied by a suitable expansion rate and good degradation characteristics. The antitumor activities of Fe3O4-THP-CS/GP were more effective both in vitro and in vivo than the free THP solution. In the study of its mechanism, results showed that Fe3O4-THP-CS/GP suppressed the expression of occludin (OCLN) and affected tight junctions (TJ) between urothelial cells to promote THP absorption.
The transcriptome landscapes of allantochorion and vitelline-chorion in equine day 30 conceptus
Authors: Shen Yingchao , Ren Hong , Davshilt Toli , Tian Shuyue , Wang Xisheng , Yi Minna , Ulaangerel Tseweendolmaa , Li Bei , Dugarjav Manglai , Bou Gerelchimeg
Published: August 2022

During equine early gestation, trophectoderm forms chorion tissue, which is composed of two parts that one is covering allantoin, called allantochorion (AC) and another is covering yolk sac, which here we call vitelline-chorion (VC). Given that little is known about the equine trophoblast-derived chorion differentiation at an early stage, we first compared the transcriptome of AC and VC of day 30 equine conceptus based on RNA-sequencing. As a result, we found that compared to VC, there are 484 DEGs, including 305 up- and 179 down-regulated genes in AC. GO and KEGG analysis indicated that up-regulated genes in AC are mainly cell proliferation and cell adhesion-related genes, participating in allantois expansion and allantochorionic-placenta formation; dominant genes in VC are extracellular exosome and other cell adhesion-related genes implicated in direct and indirect conceptus-maternal communication. Additionally, as for the progenitor chorion tissue of equine chorionic gonadotropin secreting endometrium cup—the chorionic girdle (CG), which locates at the junction of the dilating AC and regressing VC, we revealed its unique gene expression pattern and the gene regulation during its further differentiation in vitro. Collectively, this study sheds light on the molecular events regarding the trophoblast differentiation and function at an early stage of the equine preimplantation conceptus.
Path Under Construction: Challenges Beyond S-Framed Motion Event Construal in L2 German
Authors: Madlener-Charpentier Karin , Liste Lamas Elsa
Published: August 2022

The encoding of motion events is known to be challenging for second language (L2) users, particularly if the lexicalization patterns of their first language (L1) diverge from those of the L2. This paper analyzes oral and written motion event descriptions produced by advanced L2 users of German, an information-dense satellite-framed language. Based on L2 usage and error patterns, we discuss six major challenges with respect to motion event encoding and, more specifically, path encoding. These challenges clearly go beyond event construal and the acquisition of the basic satellite-framed lexicalization pattern (e.g., verb semantics) as well as beyond expected challenges related to the use of prepositional phrases (e.g., prepositional semantics, case marking). Advanced L2 users actually particularly struggle with “smaller” path encoding devices such as particles, locative and directional adverbs, their formal and functional differentiation, their usage patterns and combinatorial potential. These aspects seem to be challenging for advanced L2 users of German with either verb-framed L1s (French, Spanish) or satellite-framed L1s (Danish, English). We therefore discuss characteristics of the target language input that might explain why L2 users struggle with identifying and differentiating these path encoding devices, their usage, and combinatorial patterns. We sketch potential implications for L2 teaching.
Exploring views on affective haptic devices in times of COVID-19
Authors: Ipakchian Askari Sima , Huisman Gijs , Haans Antal , IJsselsteijn Wijnand A.
Published: August 2022

Affective haptic devices (AHDs) are communication technologies utilizing the sense of touch, and include mediated social touch (MST), symbolic haptic messaging, and awareness systems that, for example, let one feel another person's heartbeat. The COVID-19 pandemic and consequent social distancing measures have led to a reemphasis of the importance of social touch, and many people have experienced firsthand what it is like to miss touching loved ones. This offers an excellent opportunity to study people's intention to use AHDs. For this purpose, a survey study (n= 277) was conducted combining qualitative and quantitative data analysis methods. Touch deprivation, resulting from not being able to touch a loved one, was associated with intention to use AHDs: the more deprived an individual, the higher his or her intention to use AHDs. Technology readiness and touch aversion did not affect intention to use AHDs. AHDs for symbolic messaging gained higher interest than MST and awareness devices, and long-distance relationships were seen as the most likely scenario for using AHDs. Bi-directionality, synchronicity, and symmetry were regarded as important features for providing shared meaning and a sense of connectedness. Reviewability, multimodality, and actuation type were also deemed important. Limitations of the study and implications for the design of AHDs are discussed.
Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
Authors: Zhuo Chengui , Zhao Jianqiang , Wang Qiqi , Lin Zujin , Cai Haipeng , Pan Huili , Chen Lei , Jin Xiangyu , Jin Hong , Xu Longwei , Tao Xiyan
Published: August 2022

Background

Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated.

Methods

We identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold (P < 5 × 10−8) from UK Biobank participants and evaluated these in relation to risk of CVDs. MR estimates was calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analysis was further conducted.

Results

Genetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950–0.984; p = 0.000222), however, suggestive significance was found between left-hand grip strength and atrial fibrillation (OR, 0.977; 95% CI, 0.957–0.998; p = 0.033). Results were similar in several sensitivity analysis.

Conclusion

Our study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures.
Construction and analysis of competing endogenous RNA network and patterns of immune infiltration in abdominal aortic aneurysm
Authors: Chen Liang , Wang Shuangshuang , Wang Zheyu , Liu Yuting , Xu Yi , Yang Shuofei , Xue Guanhua
Published: August 2022

Background

Various studies have highlighted the role of circular RNAs (circRNAs) as critical molecular regulators in cardiovascular diseases, but its role in abdominal aortic aneurysm (AAA) is unclear. This study explores the potential molecular mechanisms of AAA based on the circRNA-microRNA (miRNA)-mRNA competing endogenous RNA (ceRNA) network and immune cell infiltration patterns.

Methods

The expression profiles of circRNAs (GSE144431) and mRNAs (GSE57691 and GSE47472) were obtained from the Gene Expression Omnibus (GEO). Then, the differentially expressed circRNAs (DEcircRNAs) and mRNAs (DEmRNAs) between AAA patients and healthy control samples, and the target miRNAs of these DEmRNAs and DEcircRNAs were identified. Based on the miRNA-DEmRNAs and miRNA-DEcircRNAs pairs, the ceRNA network was constructed. Furthermore, the proportion of the 22 immune cell types in AAA patients was assessed using cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT) algorithm. The expressions of key genes and immune cell infiltration were validated using clinical specimens.

Results

A total of 214 DEmRNAs were identified in the GSE57691 and GSE47472 datasets, and 517 DEcircRNAs were identified in the GSE144431 dataset. The ceRNA network included 19 circRNAs, 36 mRNAs, and 68 miRNAs. Two key genes, PPARG and FOXO1, were identified among the hub genes of the established protein-protein interaction between mRNAs in the ceRNA network. Moreover, seven types of immune cells were differentially expressed between AAA patients and healthy control samples. Hub genes in ceRNA, such as FOXO1, HSPA8, and RAB5C, positively correlated with resting CD4 memory T cells or M1 macrophages, or both.

Conclusion

In conclusion, a ceRNA interaction axis was constructed. The composition of infiltrating immune cells was analyzed in the abdominal aorta of AAA patients and healthy control samples. This may help identify potential therapeutic targets for AAA.
Exploring the Connection of Brain Computer Interfaces and Multimedia Use With the Social Integration of People With Various Motor Disabilities: A Questionnaire-Based Usability Study
Authors: Lazarou Ioulietta , Nikolopoulos Spiros , Georgiadis Kostas , Oikonomou Vangelis P. , Mariakaki Agnes , Kompatsiaris Ioannis
Published: August 2022

We have designed a platform to aid people with motor disabilities to be part of digital environments, in order to create digitally and socially inclusive activities that promote their quality of life. To evaluate in depth the impact of the platform on social inclusion indicators across patients with various motor disabilities, we constructed a questionnaire in which the following indicators were assessed: (i) Well Being, (ii) Empowerment, (iii) Participation, (iv) Social Capital, (v) Education, and (vi) Employment. In total 30 participants (10 with Neuromuscular Disorders-NMD, 10 with Spinal Cord Injury-SCI, and 10 with Parkinson's Disease-PD) used the platform for ~1 month, and its impact on social inclusion indicators was measured before and after the usage. Moreover, monitoring mechanisms were used to track computer usage as well as an online social activity. Finally, testimonials and experimenter input were collected to enrich the study with qualitative understanding. All participants were favorable to use the suggested platform, while they would prefer it for longer periods of time in order to become “re-awakened” to possibilities of expanded connection and inclusion, while it became clear that the platform has to offer them further the option to use it in a reclining position. The present study has clearly shown that the challenge of social inclusion cannot be tackled solely with technology and it needs to integrate persuasive design elements that foster experimentation and discovery.
Transforming healthcare through a digital revolution: A review of digital healthcare technologies and solutions
Authors: Naik Nithesh , Hameed B. M. Zeeshan , Sooriyaperakasam Nilakshman , Vinayahalingam Shankeeth , Patil Vathsala , Smriti Komal , Saxena Janhavi , Shah Milap , Ibrahim Sufyan , Singh Anshuman , Karimi Hadis , Naganathan Karthickeyan , Shetty Dasharathraj K. , Rai Bhavan Prasad , Chlosta Piotr , Somani Bhaskar K.
Published: August 2022

The COVID-19 pandemic has put a strain on the entire global healthcare infrastructure. The pandemic has necessitated the re-invention, re-organization, and transformation of the healthcare system. The resurgence of new COVID-19 virus variants in several countries and the infection of a larger group of communities necessitate a rapid strategic shift. Governments, non-profit, and other healthcare organizations have all proposed various digital solutions. It's not clear whether these digital solutions are adaptable, functional, effective, or reliable. With the disease becoming more and more prevalent, many countries are looking for assistance and implementation of digital technologies to combat COVID-19. Digital health technologies for COVID-19 pandemic management, surveillance, contact tracing, diagnosis, treatment, and prevention will be discussed in this paper to ensure that healthcare is delivered effectively. Artificial Intelligence (AI), big data, telemedicine, robotic solutions, Internet of Things (IoT), digital platforms for communication (DC), computer vision, computer audition (CA), digital data management solutions (blockchain), digital imaging are premiering to assist healthcare workers (HCW's) with solutions that include case base surveillance, information dissemination, disinfection, and remote consultations, along with many other such interventions.
An integration engineering framework for machine learning in healthcare
Authors: Assadi Azadeh , Laussen Peter C. , Goodwin Andrew J. , Goodfellow Sebastian , Dixon William , Greer Robert W. , Jegatheeswaran Anusha , Singh Devin , McCradden Melissa , Gallant Sara N. , Goldenberg Anna , Eytan Danny , Mazwi Mjaye L.
Published: August 2022

Background and Objectives

Machine Learning offers opportunities to improve patient outcomes, team performance, and reduce healthcare costs. Yet only a small fraction of all Machine Learning models for health care have been successfully integrated into the clinical space. There are no current guidelines for clinical model integration, leading to waste, unnecessary costs, patient harm, and decreases in efficiency when improperly implemented. Systems engineering is widely used in industry to achieve an integrated system of systems through an interprofessional collaborative approach to system design, development, and integration. We propose a framework based on systems engineering to guide the development and integration of Machine Learning models in healthcare.

Methods

Applied systems engineering, software engineering and health care Machine Learning software development practices were reviewed and critically appraised to establish an understanding of limitations and challenges within these domains. Principles of systems engineering were used to develop solutions to address the identified problems. The framework was then harmonized with the Machine Learning software development process to create a systems engineering-based Machine Learning software development approach in the healthcare domain.

Results

We present an integration framework for healthcare Artificial Intelligence that considers the entirety of this system of systems. Our proposed framework utilizes a combined software and integration engineering approach and consists of four phases: (1) Inception, (2) Preparation, (3) Development, and (4) Integration. During each phase, we present specific elements for consideration in each of the three domains of integration: The Human, The Technical System, and The Environment. There are also elements that are considered in the interactions between these domains.

Conclusion

Clinical models are technical systems that need to be integrated into the existing system of systems in health care. A systems engineering approach to integration ensures appropriate elements are considered at each stage of model design to facilitate model integration. Our proposed framework is based on principles of systems engineering and can serve as a guide for model development, increasing the likelihood of successful Machine Learning translation and integration.
Oculomotor deficits in Parkinson's disease: Increasing sensitivity using multivariate approaches
Authors: Bredemeyer Oliver , Patel Salil , FitzGerald James J. , Antoniades Chrystalina A.
Published: August 2022

Parkinson's disease (PD) affects several domains of neurological function, from lower-level motor programs to higher cognitive processing. As certain types of eye movements (saccades) are fast, non-fatiguing, and can be measured objectively and non-invasively, they are a promising candidate for quantifying motor and cognitive dysfunction in PD, as well as other movement disorders. In this pilot study, we evaluate the latency (reaction time), damping (resistance to oscillation), and amplitude of saccadic movements in two tasks performed by 25 PD patients with mild to moderate disease and 26 age-matched healthy controls. As well as general increases in reaction time caused by PD, the damping of saccadic eye movements was found to be task-dependent and affected by disease. Finally, we introduce a proof-of-concept multivariate model to demonstrate how information from saccadometry can be combined to infer disease status.
Multi-scale deformation characteristics and mechanism of red-bed mudstone in dry-wet environment
Authors: Yu Fei , Tong Kaiwen , Fu Zhenghao , Feng Gaoshun , Zhou Zhe , Chen Shanxiong , Dai Zhangjun
Published: August 2022

Repeated swelling-shrinking behaviors of red-bed mudstone poses a potential threat to high-speed railways. Through swelling test and dry-wet cycle test, the deformation law of mudstone samples was discussed. Using X-ray CT scanning, MIP and BET technology, the inner relationship between deformation and structural characteristics were clarified. The results showed that the surface of sample was chipped and peeled off after two cycles. During the dehumidification, the mudstone has undergone three stages of shrinkage adjustment, accelerated shrinkage and stable shrinkage. Uneven tensile stress caused by evaporation of water molecules in the initial stage of drying delayed the shrinkage. Initial water content was opposite to the changes of stable strain after water immersion and residual strain after dehydration, while it was positively correlated with environmental temperature. Porosity and connectivity keep increasing with the continuous cycle, and the number appeared to gradually descend from the two ends to the middle in space. Successive drying and wetting promoted a wider range of diameter-length ratio by the swelling of hydrophilic minerals and uneven shrinkage stress. Spatial orientation also transitioned to the polar angle. Specifically, the structure evolved from the layered shape to the tree-like and net-like in order. Microscopic scale mainly included uniform flat pores and wedge-shaped capillary pores, ranging from 10 to 80 Å. The number of cycles didn’t affect the morphology of micropores, but only caused volume and specific surface area to enlarge. The existence of clays generated irreversible deformation of micropores and initiated the gradual extension. This work will provide key data and necessary methods for the geohazard problems.
Numerical study on the energy performance of an axial-flow pump with different wall roughness
Authors: Chen Yuling , Sun Qing , Li Zhixiang , Gong Yan , Zhai Jianwei , Chen Huixiang
Published: August 2022

Pumping stations play an important role in China’s South-to-North Water Diversion, agricultural irrigation, and municipal drainage. Some pumping station units have been put into operation for long periods with improper operation and require maintenance. Moreover, the surfaces of the flow components have been worn and corroded, leading to an increase in the relative roughness and a decrease in the hydraulic performance efficiencies of pumping station units. In this work, we performed field measurements and numerical simulations to study the influence of the wall roughness on the hydraulic performance of slanted axial-flow pump devices under multiple working conditions. The effects of the wall roughness of the impeller chamber on the hydraulic performance of the pump, the guide vane chamber, and the inlet and outlet flow channel were investigated. Wall roughness had the largest influence on the hydraulic performance of the pump and the smallest influence on the inlet and outlet flow channels. For devices with different roughness values on the impeller chamber wall under different flow rate conditions, the performance of the pump device worsened under the large-flow-rate condition, and the device performance was better under the small-flow-rate and designed flow conditions. The efficiency of the slanted axial-flow pump device decreased significantly as the flow rate increased. Under the same flow rate condition, the performance of the device with Ra = 5 μm was similar to that with a smooth wall, where Ra is the roughness of the wall. With the increase in the roughness, the uniformity of the axial velocity distribution coefficient decreased, and the velocity-weighted average drift angle increased. External characteristic parameters, such as the torque and the static pressure, on the blade pressure surface gradually decreased with the increase in the wall roughness. A large roughness could induce instability of the wall flow and enhance the turbulent kinetic energy near the blade surface.
Integrated stability control for a vehicle in the vehicle-to-grid system on low adhesion coefficient road
Authors: Wang Yujie , Lei Yu , Wang Peipei
Published: August 2022

For the vehicle-to-grid system, the dynamic performance of the vehicle in the transportation system is quite crucial. The stability of the vehicle is the basis of the whole system. Compared to the traditional vehicle, the vehicle with a torque distribution system allows the vehicle to have a better dynamic performance. The torque distribution method has attracted a lot of attention from researchers. Most of the current work focuses on the vehicle on the concrete road. To improve the vehicle lateral stability in the critical work condition, the nonlinear reference model and vehicle dynamic model with 8 degrees of freedom are established based on the vehicle dynamic theory. An integrated active front steering (AFS) and direct yaw control (DYC) controller are designed based on LQR (Linear quadratic regulator) and vehicle stability phase portrait. To evaluate the performance of the vehicle on the road with a relatively low adhesion coefficient. The double lane-change and fishhook maneuver are chosen as the work condition. The steering angle, wheel torque, vehicle routine, phase portrait track, and yaw rate are calculated and compared. The simulation result validates the effectiveness of the proposed integrated AFS and DYC control method. The stability of the vehicle on the low adhesion coefficient road can lay a good foundation of the vehicle-to-grid system.
Impacts of salinization caused by sea level rise on the biological processes of coastal soils - A review
Authors: Mazhar Sadat , Pellegrini Elisa , Contin Marco , Bravo Carlo , De Nobili Maria
Published: August 2022

Soil salinization caused by sea level rise threatens coastal agricultural soils and geochemically important wetlands worldwide. The aim of this review is to outline expected changes in soil biological activity by discussing the combined effects of salt stress and flooding on plants productivity and soil microbial communities, which determine consequences on fluxes of C, N and P. Finally, it outlines the expected repercussions on greenhouse gases emissions. The prediction of outcomes is made difficult by the concomitant and sometimes contrasting actions of flooding and seawater intrusion on partly acclimated and non-acclimated environments. Non-salt acclimated plants suffer from osmotic stress, but also from reduced O2 solubility. Microbial biomass declines with increasing salinity and microbial communities shift in composition. Large concentrations of Cl− inhibit nitrification, but salinity stimulates N2O fluxes. Impacts on C mineralisation rates is variable but enhanced by the larger availability of terminal electron acceptors. The reduction of Fe combined with that of SO42− could enhance P mobility. Salinization affects methanogenesis which is constrained in favour of SO42− reduction. Consequences are largely site specific and difficult to predict because of the complex network of processes occurring simultaneously in different compartments (i.e., soil, microbiome, vegetation). The distinction between short and long term effects is also important. A reliable prediction of outcomes at a planetary scale will only result from more precise inventories and monitoring of areas displaying specific similarities and from the implementation from these well-defined data sets of specifically devised models whose results can be finally combined on a weighted basis.