MODERN PHYTOTHERAPY IN THE COMPLEX TREATMENT OF PATIENTS WITH ACUTE UNCOMPLICATED CYSTITIS
Authors: Gurzhenko Yu.M. , Shulyak O.V. , Spyridonenko V.V. , Gurzhenko O.Yu. 
Published: January 2025

INTRODUCTION. The article demonstrates the experience of use the FLAVIA multicomponent plant complex in the treatment of acute cystitis in women.
MATERIALS AND METHODS. The work evaluated the effectiveness and safety of the multicomponent FLAVIA plant complex in the treatment of acute cystitis in women. Compared with the use of standard antibacterial therapy. 80 patients with acute cystitis, aged from 20 to 40 years, took part in the study: 1 group (clinical): 40 patients took the multicomponent herbal complex FLAVIA (1 capsule twice a day, regardless of food intake, for 30 days) together with antibacterial therapy (phosphomycin — 3 g once); Group 2 (control): 40 patients received only antibacterial therapy (phosphomycin — 3 g once). Control visits took place after 7 (to determine the immediate results of treatment) and after 14 and 30 days after the start of therapy. To study the speed of elimination of symptoms and the dynamics of the disease’s impact on quality of life, patients were asked to fill out ACSS and VAS pain questionnaires. Studies of the general analysis of urine and bacteriological analysis of urine were carried out three times. The effectiveness of therapy was evaluated by the final result after antibiotic therapy. One of the main indicators of the effectiveness of treatment was the percentage of relapses and repeated diseases within 3 months. The following research methods were used: examination, ultrasound of the organs of the abdominal cavity, kidneys and bladder; general laboratory studies; bacteriological examination of urine; assessment of acute cystitis symptoms (ACSS questionnaire); pain assessment by visual analog scale (VAS).
RESULTS AND THEIR DISCUSSION. As a result of the course of therapy, all patients noted a significant improvement in their state. The effectiveness of therapy in eliminating dysuric symptoms was 97.4% in the first group, and 88.9% in the 2nd group (р<0.05). For the longest time, the patients were bothered by symptoms of burning during urination — in all patients of group 1, it was eliminated on the 7th day, and in 3 patients of group 2, this symptom bothered them even a month after therapy. The feeling of not completely emptying the bladder in all patients of group 1 was eliminated on the 3rd day, and in 1 person from group 2, this symptom also appeared a month after therapy. The average duration of symptoms of acute cystitis in the studied control group was 1.6–2.2 times longer than in the comparison group according to various symptoms. All patients of the clinical group noted a decrease in dysuric phenomena on the 3rd day of treatment, and 76.3% noted the absence of dysuric manifestations. In the control group, only on the 14th day of treatment, the level of absence of dysuria was similar (77.8%). Analyzing the data of the general analysis of urine, it should be noted that leukocyturia before therapy was 100% characteristic of all patients, and on the 14th day it remained in 4 (10.5%) patients of 1 group and in 12 (33.3%) patients of 2 group (p<0.01). On the 30th day, leukocyturia was not noted in any patient who took the multicomponent herbal complex FLAVIYA, but in 4 (11.1%) cases among the patients of the 2nd group, a relapse of the disease was noted. Erythrocyturia was eliminated in all 17 patients of 1 group who had it at the beginning of the study on the 7th day of therapy, and in all 15 patients with such a symptom of 2 group — only on the 14th day. Changes in the peripheral blood — leukocytosis, an increase in ESR of more than 15 mm/h and an increase in the level of C-reactive protein were eliminated in patients of both groups by the 7th day of therapy. Subfebrile temperature disappeared as a result of treatment up to 3 days in both groups. The research data indicate a high overall therapeutic efficiency of complex therapy using FLAVIA (97.4%), in contrast to the control group (88.9%). As a result of the analysis of the data  of the ACSS questionnaire, it was found that the average total score of the ACSS questionnaire for typical symptoms before therapy was 9.9±2.4 points, and for the quality of life section — 5.4±1.2 points in patients of group 1 and 9.2±2.1 points and 5.1±1.0 points in patients of group 2. This testified to the high expressiveness of the symptoms of acute cystitis. In terms of dynamics, we compared the average scores of the ACSS-typical domain between the 1st and 30th day of therapy, and on the 30th day the indicator was 2.2±0.3 in the clinical group; and in the control 4.1±0.8 points. From this, it can be concluded that the use of the multicomponent herbal complex FLAVIA in the treatment of acute cystitis had a greater dynamics of eliminating the symptoms of the disease according to the ACSS questionnaire, compared to the therapy in patients without the use of FLAVIYA. As a result of the analysis of pain syndrome intensity data according to the VAS scale, the average score before therapy was 8.3±1.3 points in patients of group 1 and 8.6±1.4 points in patients of group 2. The pain syndrome was characterized by pain of varying intensity and was most often localized in the lower abdomen. It was diagnosed in 32 (84.2%) patients of group 1 and in 29 (80.6%) of group 2. After the start of treatment, the pain syndrome was eliminated in all patients of group 1 on the 5th day, and in patients of group 2, it was eliminated only after 14 days of therapy. From the data it can be concluded that the use of FLAVIA in the treatment of acute cystitis probably accelerates the elimination of pain sensations both in terms of presence and intensity of pain in comparison with the treatment of patients without the use of FLAVIA. Good tolerability of the drug was noted. Adverse reactions as a result of taking the multicomponent herbal complex FLAVIA have not been detected.
CONCLUSIONS. According to the obtained results and literature data, we can say about the potentiation of the effect of antibiotics by the FLAVIA multicomponent plant complex, which is manifested in the high therapeutic efficiency of the treatment of women with acute cystitis, which is already 97.4% on the 14th day, compared to the effectiveness of the control group on this time, which was 77.8% (p<0.01). Similar results of the therapy were obtained according to the ACSS questionnaire, where the average score for 30 days was 2.2±0.3 and 4.1±0.8 (p<0.01) in the clinical and control groups, respectively, indicating better dynamics elimination of symptoms of the disease in the clinical group in comparison with therapy in patients without use of FLAVIA. The multicomponent plant complex FLAVIYA has a anti-inflammatory effect, which is manifested in the reduction of pain syndrome and dysuric phenomena already on the 3rd day of treatment, which decreased significantly more and were eliminated faster than in the control group. Along with the clinical effectiveness, evidence of the bacteriological effectiveness of the multicomponent herbal complex was obtained, which, together with the absence of side effects, confirms the feasibility of wide clinical use of FLAVIA for the complex treatment of women with acute cystitis or exacerbation of chronic cystitis.