bluuebunny/crossref_metadata_2025 huggingface dataset:
PROCESSING AND STORAGE OF DIFFERENT DATA WITH THE HELP OF BI-TECHNOLOGIES
Authors:   Lviv Polytechnic National University, Ukraine, Boyko Nataliya
Published: September 2022

Conditions for the development of modern information space indicate the need to process large amounts of structured, poorly structured and unstructured data, which are in heterogeneous sources. The study describes the approaches, models, methods and tools for building data warehouses, formulates the purpose and objectives of the study, and the concept of building corporate repositories. This section discusses the input and output data features that the system will process. The information model of OLTP systems and data warehouses is also designed; logical essences and their business needs are described. The input data will be the result of the OLTP system, which simulates the operation of the online store. Then, by various means, different amounts of data will be transferred with specific processing to the data warehouse, from the structure of which it will be possible to obtain the original data for further analysis. This section explores the various tools for implementing the system describes their advantages and disadvantages. SQLServer was chosen as the data processing mechanism and DatabaseEngine / SSIS packages as the tools for forming the integration layer and ETL processes. The necessary software and hardware have been included. The object of the study is the process of migrating data from a database that works directly with a business program (OLTP system) to a data warehouse (OLAP system) for further archival storage and analysis. The work aims to create a relational database that will simulate the work of the online store, create an appropriate data warehouse and study the speed of the ETL process of data transfer to the data warehouse in different ways. The main tasks for the realization of the research goal should include construction of a relational database and its filling with suboptimal data; construction of a data warehouse; creation of ETL process with the help of SSIS packages; design of ETL process using T-SQL; comparison of the obtained results and conclusions. We also considered the software implementation, which conducted a study of the speed of data transfer using two selected tools and felt some functionality of the system so that the user interacted correctly with it. To achieve this goal, developing a data warehouse on a hybrid approach is necessary and configuring the ETL process between the relational database and the data warehouse using SSIS packages. To perform experiments, you need to compare data transfer efficiency on tables of different dimensions. As a result of the study, a three-tier system was created, consisting of an OLTP system as a transactional layer, ETL processes using DatabaseEngine and SSIS packages, as an integration layer and a data warehouse built on a hybrid principle as an analytical layer. The implemented system is analogous to the latest self-service system, as it can provide its business needs without third-party funds.
STUDY OF THE INFLUENCE OF UNFAVORABLE VEGETATION CONDITIONS ON AGRO-ECOLOGICAL RESISTANCE OF BEAN VARIETIES
Authors:   Vinnytsia National Agrarian University, Ukraine, Tkachuk Oleksandr , Mordvanyuk Myroslava ,   Vinnytsia National Agrarian University, Ukraine
Published: September 2022

Among the leguminous crops in world agriculture, the bean ranks second after soybeans in terms of gross yield and is in great demand as a food product. Beans as a food product is important in the food balance of the country, because its seeds in protein content exceeds cereals in 2-3 times or more, and contains 28-32%, and in green beans (asparagus beans) – 17-21% balanced in amino acid composition of protein, as well as more than 40% of carbohydrates, vitamins A, B, C, E, enzymes, minerals. Despite the significant sown area of beans in the world, which is about 26 million hectares, in Ukraine in 2019, its crops were significantly inferior to the traditional for our country leguminous crops – soybeans and peas and amounted to only 42.0 thousand hectares, which was about 7 % in the structure of leguminous crops. Insignificant bean sown areas in Ukraine are combined with a low seed yield of 1.6 t/ha. As part of research work of Vinnytsia National Agrarian University, the authors of the research are executors of applied research on the topic: «Development of methods for improving the technology of growing legumes using biofertilizers, bacterial preparations, foliar fertilizers and physiologically active substances» (Mazur V.A., Didur I.M., Tkachuk O.P., Pantsyreva H.V.), state registration number 0120U102034.
GENETIC REGULATION OF THE METABOLISM OF METHIONINE, HOMOCYSTEINE AND VITAMINS В9, В12 IN CHILDREN LIVING NEAR THE CHERNOBYL EXCLUSION ZONE
Authors:   Ecology and Health Coordination and Analytical Centre, Ukraine, Bandazheuski Yuri , Dubovaya Nataliia ,   Shupyk National Healthcare University of Ukraine, Ukraine
Published: September 2022

In 2015, the majority of children living near the Chernobyl exclusion zone had an elevated level of homocysteine in the blood, however, at the same time, the level of serum vitamins B9 and B12 was determined within the reference values. Considering that B vitamins are cofactors of the folate cycle enzymes that regulate the metabolism of the sulfur-containing amino acids methionine and homocysteine, it was important to determine the causes of this phenomenon. The purpose of this study was to identify correlations between vitamins В12, В9 and homocysteine, as well as vitamin В6, taking into account the genetic factor, in a group of children living under constant radiation exposure associated with the Chernobyl nuclear power plant accident. Research methods. The results of laboratory and instrumental examination of 178 children aged 12-17 from the Ivankovsky district of the Kyiv region were used. Immunochemical, genetic, spectrometric and statistical research methods were used. Results. Correlation analysis was used to study the relationship between the levels of homocysteine, B12, B9, B6 in the blood of children, taking into account their genetic status of folate cycle and the content of 137Cs in the body. An elevated level of homocysteine (more than 10.0 μmol/l) was detected in 73.0 % of the examined patients. The causes of hyperhomocysteinemia in children living near the Chernobyl exclusion zone are mutations in the folate cycle genes, insufficient content of vitamins B9 and B12 in the body, as well as the impact of an environmental factor associated with the Chernobyl nuclear power plant accident. The pathogenesis of the development of hyperhomocysteinemia in various variants of folate cycle genotypes is presented in detail. Conclusions. In assessing vitamins В9 and B12 status in children living near the Chernobyl exclusion zone, one should take into account not only their blood values but also that of homocysteine and vitamin В6, the specific activity of radionuclides in the body and the state of the genetic apparatus of the folate cycle. Despite the fact that homocysteine impaired remethylation processes occurred in most children living near the Chernobyl exclusion zone, the correction of their metabolism with vitamins В9 and B12 should be carried out individually, taking into account the state of the genes that control the folate cycle.
LUNG CANCER BIOMARKERS
Authors:   Sumy State University, Ukraine, Moskalenko Yuliia , Smorodska Olga ,   Sumy State University, Ukraine
Published: September 2022

According to CLOBOCAN, in 2040 the incidence of cancer will increase by 47% compared to 2020. Lung cancer is the leading cause of death from malignant neoplasms in both men and women. In 2020, 2.2 million new cases of lung cancer and 1.8 million deaths from the disease were registered. It is unlikely that this problem will be solved soon. Therefore, doctors are faced with the question of early diagnosis of malignant neoplasms, determination of prognostic factors and personification of treatment. In Ukraine, about 42% of lung tumors are diagnosed at an advanced stage. Such patients have a poor prognosis and an overall 5-year survival of no more than 5%. This is because non-small cell lung cancer has a low sensitivity to classical cytotoxic therapy. Therefore, it is important to know which part of the pathological process can be targeted so that the patient receives the maximum effect from treatment and the minimum number of side effects. For patients whose cancer can be completely removed surgically, personalization of treatment is also important. Patients usually receive adjuvant chemotherapy after radical surgical treatment for stage IV-IIIA lung cancer. Unfortunately, in some of them in the coming years after surgery there is a recurrence of the disease. Therefore, the study of molecular genetics and other biological markers is important because it allows you to choose the path for targeted, immunotherapy or intensification of classical chemotherapy by increasing the total number of cycles. The review presents the main molecular genetics and immunohistochemical markers of lung cancer, which determine the prognosis and treatment tactics. The expediency of testing tumor tissue for the most common genetic mutations (EGFR, B-RAF) and gene rearrangements (ALK, ROS1) is substantiated. The expediency of performing immunohistochemical research in comparison with molecular genetics and its influence on treatment tactics is considered. A comparative analysis of the reliability and informativeness of the results of immunohistochemical studies. Values of immune checkpoint inhibitors on the tumor cell surface (PD-1, PD-L, CTLA-4), intracellular immune checkpoint inhibitors (CISH), protein 53 and proliferation marker Ki-67 for the diagnosis of lung cancer are described. This review considers the choice of optimal treatment option based on data obtained during testing for the most common diagnostic markers of lung cancer.
The Effectiveness of Using Poetry in Developing English Vocabulary, Pronunciation and Motivation of EFL Palestinian Students
Authors: Farrah Mohammed A A , AL-Bakri Ruba
Published: September 2022

This study aims at investigating the effectiveness of using poetry in developing English vocabulary, pronunciation and motivation of EFL Palestinian students. The researcher adopted the quantitative method to collect the required data. The researcher used a questionnaire for both students and teachers to examine their attitudes towards using poetry in the language classroom. The participants of the study were both teachers and students from Hebron. The sample of study consisted of 73 female Tenth grade students and 214 English language teachers. One school has been chosen to form the experimental group. The analysis of the post-test revealed that the experimental group has significantly outperformed the control group in both vocabulary and pronunciation competences when they read poetry. Likewise, the results of the questionnaires showed that both teachers and students have positive attitudes towards using poetry in the language classroom as a means for teaching English language. In short, poetry has positive effect on developing the English vocabulary, pronunciation and increasing students’ motivation.
Planning for Eco-City in China: Policy Mobility in Path Creation of Eco-Zhuhai
Authors: Li Lingyue , Xian Shi , Qi Zhixin
Published: September 2022

Idea of eco-city booms in China’s planning practices under central state’s envisioned transition towards “ecological civilization” wherein Zhuhai stands out as an example well fitted the eco-livable paradigm. To disentangle how Zhuhai has achieved such fame, this article identifies two interlocked and nested forms of policy mobility: policy reformulation towards pro-environment and policy circulation of advanced eco-experiences, and reviews key process of eco-city planning in the city since 1980s. Rather than an explicit, long-term vision, the review suggests that Zhuhai’s reputation as an eco-city model results from cumulative effects of early policy formulation towards environmental protection upon its geographical location, its natural assets, and essentially early hysteresis in the growth race. Though subsequent development has been path-dependently locked in, it is benefitted from the planning regime wherein knowledge and experiences related to eco-city are instantly shared.
Analysis of Mathematical Problem Solving Ability Viewed from Gender Differences in Public High Schools
Authors: Umaratu Sely Jera , Ngaba Anggriati Ledu , Nggaba Mayun Erawati
Published: September 2022

This study aims to analyze students' mathematical problem solving abilities in terms of gender differences and describe the obstacles in solving problems in the form of linear programming story questions. This type of research is descriptive with a qualitative approach. The research subjects were 18 students of class XI MIA 2 SMA Negeri 1 Kambera including 9 male students and 9 female students and the supporting subjects were compulsory mathematics teachers and specialization mathematics teachers. The results of the study using the Polya indicator in terms of gender differences showed the overall average score obtained by female students with a score of 49.07 was superior to male students who scored 42.37. This shows that there are gender differences in solving a problem due to lack of understanding of the problem in question, not working carefully, rarely practicing questions.
A Linguistic Perspective on Feminisation and Gender-Inclusive Language
How Partitive Constructions Can Be Used to Uncover Implicit Gender Bias in Italian
Authors: Zanoli Emma
Published: September 2022

This article reports the results of a study on the perception of feminisation and gender mismatches in Italian. The study probes the intuition of native Italian speakers through tasks that highlight their linguistic habits. The results point to two separate but interrelated reflections. First, they show that semantic gender can override grammatical gender in partitives. Second, they reveal that the acceptance of feminine profession nouns is not widespread, especially for those nouns that refer to prestigious professions. The work presented here stems from an Italian adaptation of a study originally designed for French and German.
ἀφθονέστερον, ἀρχαιέστερον (Antiatt. α 74, Antiatt. α 75)
Authors: Tribulato Olga
Published: September 2022

This article deals with the irregular comparatives ἀφθονέστερον and ἀρχαιέστερον, discussed in the Atticist lexica Antiatt. α 74 and Antiatt. α 75.
ἡσύχιος, ἡσυχώτερος, ἡσύχιμος (Antiatt. η 6, Antiatt. η 7)
Authors: Tribulato Olga
Published: September 2022

This article provides a philological and linguistic commentary on the words ἡσύχιος, ἡσυχώτερος, ἡσύχιμος discussed in the Atticist lexica Antiatt. η 6 and Antiatt. η 7.
μειζόνως (Antiatt. μ 13)
Authors: Tribulato Olga
Published: September 2022

This article deals with the analogical comparative adverb μειζόνως, discussed in the Atticist lexicon Antiatt. μ 13.
μᾶλλον μᾶλλον (in Antiatt. μ 21)
Authors: Tribulato Olga
Published: September 2022

This article deals with the reduplicated comparative adverb μᾶλλον μᾶλλον, discussed in the Atticist lexicon Antiatt. μ 21.
μίαν μίαν (Antiatt. μ 24)
Authors: Tribulato Olga
Published: September 2022

This article deals with the reduplicated numeral μίαν μίαν, discussed in the Atticist lexicon Antiatt. μ 24.
μεῖζον μεῖζον, μικρὸν μικρόν (Antiatt. μ 22, Antiatt. μ 23)
Authors: Tribulato Olga
Published: September 2022

This article deals with the reduplicated comparative adverbs μεῖζον μεῖζον and μικρὸν μικρόν, discussed in the Atticist lexica Antiatt. μ 22, and Antiatt. μ 23.
γίγνομαι, γιγνώσκω (Moer. γ 3)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the form and pronunciation of the verbs γίγνομαι and γιγνώσκω, discussed in the Atticist lexicon Moer. γ 3.
ἀπαρκεῖ, ἀπήρκει (Moer. ο 34, Poll. 9.154)
Authors: Favi Federico
Published: September 2022

This article deals with impersonal constructions with ἀπαρκεῖ and ἀπήρκει, discussed in the Atticist lexica Moer. ο 34 and Poll. 9.154.
εὐθύς, εὐθύ, εὐθέως (Phryn. Ecl. 113, Antiatt. ε 96, Moer. ε 11)
Authors: Benuzzi Federica
Published: September 2022

This article deals with the adjective εὐθύς and the adverbs εὐθύ and εὐθέως, discussed in the Atticist lexica Phryn. Ecl. 113, Antiatt. ε 96, and Moer. ε 11.
θυμέλη (Phryn. Ecl. 135, Phryn. PS 74.9–11, Poll. 4.123)
Authors: Tribulato Olga
Published: September 2022

This article deals with the word θυμέλη, discussed in the Atticist lexica Phryn. Ecl. 135, Phryn. PS 74.9–11, and Poll. 4.123.
κυνίδιον, κυνάριον (Phryn. Ecl. 151, Antiatt. κ 87, Phryn. PS 84.22)
Authors: Tribulato Olga
Published: September 2022

This article provides a philological and linguistic commentary on the diminutives κυνίδιον and κυνάριον, discussed in the Atticist lexica Phryn. Ecl. 151, Antiatt. κ 87, and Phryn. PS 84.22.
ὤτοις (Phryn. Ecl. 182)
Authors: Favi Federico
Published: September 2022

This article deals with the analogical dative plural ὤτοις, discussed in the Atticist lexicon Phryn. Ecl. 182.
σμῆγμα, σμήχω, σμῆμα, σμάω (Phryn. Ecl. 224, Moer. σ 35)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the cognate words σμῆγμα, σμήχω, σμῆμα, and σμάω discussed in the Atticist lexica Phryn. Ecl. 224 and Moer. σ 35.
ἐνδoμενία (Phryn. Ecl. 310, Poll. 10.12–3)
Authors: Tribulato Olga
Published: September 2022

This article provides a philological and linguistic commentary on the word ἐνδoμενία (with its graphic variant ἐνδυμενία), discussed in the Atticist lexica Phryn. Ecl. 310 and Poll. 10.12–3).
ὁρκόω, ὁρκωτής, ὁρκίζω (Phryn. Ecl. 337)
Authors: Tribulato Olga
Published: September 2022

This article deals with the cognate terms ὁρκόω, ὁρκωτής and ὁρκίζω, discussed in the Atticist lexicon Phryn. Ecl. 337.
πρόσφατος (Phryn. Ecl. 351, Phryn. Ecl. 27)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the verbal adjective πρόσφατος, discussed in the Atticist lexica Phryn. Ecl. 351 and Phryn. Ecl. 27.
υἱεύς, υἱέως, υἱέα (Phryn. Ecl. 45, Phryn. Ecl. 234, Phryn. PS 118.3–4, Phryn. PS 118.5–6)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the forms υἱεύς, υἱέως, and υἱέα discussed in the Atticist lexica Phryn. Ecl. 45, Phryn. Ecl. 234, Phryn. PS 118.3–4, and Phryn. PS 118.5–6.
ἀφῆλιξ, ἀφηλικέστερος (Phryn. Ecl. 56, Phryn. PS 1.1–6, Poll. 2.17, Moer. α 153, [Hdn.] Philet. 168)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the compound ἀφῆλιξ and the comparative ἀφηλικέστερος, discussed in the Atticist lexica Phryn. Ecl. 56, Phryn. PS 1.1–6, Poll. 2.17, Moer. α 153, and [Hdn.] Philet. 168.
ἔνδον, εἴσω (Phryn. Ecl. 99, Antiatt. ε 9)
Authors: Tribulato Olga
Published: September 2022

This article deals with the correct usage of the adverbs of place ἔνδον ‘and εἴσω, as discussed in the Atticist lexica Phryn. Ecl. 99 and Antiatt. ε 9.
αὐτόκερας, αὐτόκρατον (Phryn. PS 1.9–11, Phryn. PS 29.13–5, Poll. 6.23–4)
Authors: Favi Federico
Published: September 2022

This article deals with the compounded adjectives αὐτόκερας and αὐτόκρατον, and other expressions for wine-mixing, discussed in the Atticist lexica Phryn. PS 1.9–11, Phryn. PS 29.13–5, and Poll. 6.23–4.
ἄπλυτος πώγων (Phryn. PS 4.1–2)
Authors: Favi Federico
Published: September 2022

This article deals with the expression ἄπλυτος πώγων discussed in the Atticist lexicon Phryn. PS 4.1–2.
ἄτεγκτος (Phryn. PS 7.7–9)
Authors: Favi Federico
Published: September 2022

This article provides a philological and linguistic commentary on the word ἄτεγκτος discussed in the Atticist lexicon Phryn. PS 7.7–9.
ἀμφίκαυστις (Phryn. PS fr. 18)
Authors: Tribulato Olga
Published: September 2022

This article deals with the term ἀμφίκαυστις, discussed in the Atticist lexicon Phryn. PS fr. 18.
Work Environment and Empowerment on Craftsmen Productivity at The Furniture Industry Center in Lumajang
Authors: Hartono Hartono
Published: September 2022

The human aspect holds an important role in sustainability and development of the company because basically every company activity is never separated from the human element. Production, marketing and technology activities cannot run without being carried out by humans. Both large and small companies, in the human resource approach means each organization or company must be able to create a sense of secure and satisfaction so that the human resources in work environment become competitive. The objective of this study is to determine the effect of work environment and empowerment on craftsmen productivity at Furniture Industry Center in Karangbendo village, Lumajang. The independent variables are work environment and empowerment. The dependent variable is productivity. The respondent of the study are craftsmen at Furniture Industry Center in Karangbendo village, Lumajang with a sample of 30. By using multiple linear regression analysis technique, the results obtained that the work environment has a significant effect on productivity, the empowerment has no significant effect on productivity while simultaneously the work environment and empowerment have significant effect on productivity. The 51.3% of productivity can be explained by work environment and empowerment variables and the remaining 48.7% was affected by other variables that not examined in this study.
Policy Advocacy for Strengthening Village Governance in Developing Tourism Destination in Wangunharja Village
Authors: Pradesa Hafid Aditya , Zulvia Pepi , Syawali Andi Zhillan Sabtina
Published: September 2022

The development of tourism villages has become one of important programs of current government. Wangunharja Village, one of area in Lembang District, West Bandung Regency in West Java, has tourism potential that can be developed by stakeholders. The implementation of this community service activity uses the focus grup discussion method in order to increase understanding and involvement among stakeholders of the Wangunharja Village. The subject of the intense discussion with the Village Community was about understanding strengthening social capital in the process of developing tourism destinations. As a result, community gave a positive response and expressed their commitment in strengthening social capital such as form of collective action for managing resources in their area. This subject condition will be followed up by the Wangunharja Village Government by developing policies that encourage positive affirmations that could lead to more involvement among village communities. This activity recommends further activities in the form of workshops to guide the community in the process of developing tourism destinations in a sustainable manner.
Community Empowerment in the Middle of the Covid-19 Pandemic through Pawon Urip and Management Waste Bank
Authors: Cahyaningati Retno , Paramita Ratna Wijayanti Daniar , Ana Selvia Roos , Wiyono Mokhamad Wimbo
Published: September 2022

The existence of Covid 19 has paralyzed the world economy, including several MSME businesses out of business. The existence of Large-Scale Social Restrictions (PSBB) requires people to stay at home. To overcome problems in the food sector in the midst of the Covid-19 pandemic, the Lumajang Regency PKK Mobilizing Team initiated the formation of the Pawon Urip Program. The purpose of this Community Service Activity is to support the Pawon Urip TP-PKK Lumajang Regency Program to improve food sufficiency and community welfare. Activities carried out in this Community Service include, firstly, providing training and assistance in plant cultivation. Second, optimizing the management of the Waste Bank. Thirdly, training and mentoring on the utilization of used cooking oil waste into goods of sale value in the form of biodiesel. Community Service activities have been running smoothly. This activity certainly provides great benefits to the community, from here the community can carry out plant cultivation well, knowledge of Waste Bank management is increasing so that they can do simple bookkeeping, even saving and buying and selling waste has become the culture of the local community. Furthermore, the community can also produce biodiesel independently, as a more economical and efficient substitute.
Distinction of Degrees of Ischemic Kidney Parenchymal Injury in Children with Congenital Vesicoureteral Reflux (According to Enzymological Criteria)
Authors: Nikulina Halyna , Mygal Liudmyla , Petersburgsky Volodymyr , Kalishchuk Oles , Serbina Iryna
Published: September 2022

The objective: to evaluate the possibility of determining the levels of activity of N-acetyl-β-D-glucosaminidase B (NAG B) in urine as an enzymological marker of differentiation of ischemic damage to the renal parenchyma in children with congenital vesicoureteral reflux (VUR).
Materials and methods. 49 children aged 1 to 15 years with a verified diagnosis of unilateral VUR and 25 practically healthy children were examined. NAG B activity in urine was determined before reconstructive treatment. The limits of the reference intervals of the levels of enzyme activity in the urine of healthy children were calculated by the formula M±1.5σ.
According to the personalized analysis the patientswere divided into 3 groups: group 1 – 13 patients (the levels of NAG activity in the urine are registered from 0.8 to 2.3 units); group 2 – 14 patients (the levels of NAG activity in the urine – 2.4 to 4.5 units); group 3 – 22 patients (the levels of NAG activity in urine – 4.6 to 10.5 units.
Results. In the urine of healthy children, the activity of NAG B averages 1.56±0.096 units, σ=0.48, reference levels are recorded from 0.8 to 2.3 units. In the urine of the 1st group, the levels of NAG B activity are equal to 1.61±0.13 units correspond to the control values and are evaluated as zero degree of ischemic damage of a renal parenchyma; in the urine of the 2nd group – 3.97±0.17 units exceed the average control values by 1.6–2.9 times and are assessed as moderate or I degree of ischemic damage to the renal parenchyma; in the urine of the 3rd group – 7.50±0.39 units exceed the average control values by 3 times or more and are assessed as severe or II degree of ischemic damage to the renal parenchyma (p2,3-1<0,001; p3-2<0.001).
Conclusions. The expediency of determining the activity levels of N-acetyl-β-D-glucosaminidase B in the urine of children with congenital vesicoureteral reflux, as an enzyme with pronounced renospecific properties and as enzyme marker for differentiating the degrees of ischemic damage (0, I, II) of the renal parenchyma was established. Activity levels of NAG B can be used as well for timely prevention of the development and progression severe complications through the timely appointment of the appropriate optimal corrective therapy.
Dustarin in the Treatment of Patients with Benign Prostatic Hyperplasia
Authors: Slobodyanyuk Vadym
Published: September 2022

Today the problem of treatment of patients with benign prostatic hyperplasia (BPH) is the actual one.
BPH is an age-related chronic progressive disease. It is especially relevant for men over the age of 50 years. According to WHO demographic data, the world’s population is becoming older, so the incidence of BPH is going to increase, that leads to a significant decline in quality of life due to dysfunction of the lower urinary tract and the presence of lower urinary tract symptoms (LUTS).
The management of BPH has evolved from surgery to conservative therapy. The use of 5α- reductase inhibitors, which affects the pathogenetic links of the disease, reduces the concentration of dihydrotestosterone and induces the apoptosis of epithelial cells of the prostate, is pathogenetically justified in the treatment of BPH.
The objective: to study the effectiveness of treatment of BPH with dutasteride, which belongs to the group of 5α-reductase inhibitors.
Materials and methods. 58 patients with BPH 52-75 years old were examined. The persons were divided into two groups. The patients in the first group received dutasteride for 6 months, the second group – for 12 months.
All patients were examined ambulatory by the laboratory and instrumental diagnostic methods: an assessment of complaints by the International Prostate Symptom Score (IPSS), an assessment of the quality of life by the QoL scale, digital rectal and ultrasound examinations, bladder ultrasound examination, uroflowmetry, prostate-specific antigen level, general blood and urinary tests, determination of creatinine and urea. Uroflowmetry assessed the rate of urodynamics, identified and determined the degree of urinary disorders .
Results. A positive effect of dutasteride treatment was observed in patients of both groups, but the best results were in the second group. The regression of LUTS, decreased pancreatic volume and residual urine output were in the patients.
Conclusions. The results of the research demonstrated that dutasteride is an effective agent in the treatment of benign prostatic hyperplasia (BPH), which acts on the mechanism of hyperplasia. The drug is well tolerated by patients. The effect of dutasteride treatment is achieved through its continuous and long-term use.
The timely diagnosis of BPH and its treatment will allow to stop the pathological process and return the man to a normal quality of life.
Treatment of Patients and Mechanisms of Development of Combined of Urolithiasis and Kidney Tumors (Literature review)
Authors: Slobodyanyuk Vadym
Published: September 2022

Urolithiasis is a disease which is characterized by the formation of stones in the urinary system and is one of the most actual problems in modern urology and medicine worldwide. Recently, there has been a steady spread of this disease. Urolithiasis ranks the second position in the structure of urological diseases in Ukraine, second only to infectious and inflammatory pathologies and accounts for 30-45 % of diseases of the genitourinary system.
Urolithiasis is manifested by the appearance of stones in the urinary system (most often the kidneys). The most common type of kidney cancer (KC) is renal cell carcinoma. It accounts for about 97 % of all kidney tumors. With the increase in the number of patients with renal tumors and urolithiasis, there is a clear tendency to increase the number of patients with a combination of these two serious diseases. Unfortunately, the question of the relationship and interdependence between the development of urolithiasis and kidney tumor remains open today.
The objective: to search, systematize and analyze scientific publications about the mechanisms of development and treatment of this combined pathology.
Infection and chronic inflammation cause the development of urothelial proliferation and the emergence of malignant neoplasms. Inflammatory cells secrete cytokines and chemokines in response to a chronic recurrent infectious-inflammatory process that causes tumor cell growth and tumor progression. Special attention in the publications is paid to the role of endothelial dysfunction in the development of kidney tumors. The importance of vascular endothelial growth factor (VEGF) in the mechanism of neoangiogenesis of KC is demonstrated. Management of the patients with combined pathology of urolithiasis and KC involves the doctor’s choice of the optimal method.
The analysis of literature publications demonstrates that today there are a number of issues devoted to the presence of KC and urolithiasis in one patient. These are the risks of such a combination, and the mechanisms of development, as well as determining the most rational and effective management in each case.
All above mentioned cause the need for further study of the treatment of patients with urolithiasis and kidney tumor.
Design Science Research als wissenschaftliche Herangehensweise für Abschlussarbeiten mit Gestaltungsauftrag in anwendungsorientierten Studiengängen
Authors: Weber Irene
Published: September 2022

Der Forschungsansatz Design Science Research eignet sich sehr gut für Abschlussarbeiten mit Gestaltungsauftrag in anwendungsorientierten Studiengängen, hat sich jedoch auch als schwierig umsetzbar und erklärungsbedürftig gezeigt. Hier wird ein einfach umsetzbares Vorgehensmodell nach Design Science Research für Abschlussarbeiten mit Gestaltungsauftrag in der Industrie vorgestellt, zusammen mit einer Gliederungsvorlage und erklärenden Visualisierungen zu Design Science Research. Die Gliederungsvorlage wird an einem Beispiel demonstriert. Erste Anwendungen haben gezeigt, dass das Vorgehensmodell den Studierenden Hilfestellung bietet und das Schreiben gut strukturierter, aussagekräftiger Abschlussarbeiten mit Gestaltungsauftrag erleichtern kann.
Review: Model-based Systems Engineering and Artificial Intelligence for Engineering of Sustainable Systems – What contribution can systems engineering and artificial intelligence provide for the engineering of sustainable systems as of today?
Authors: Schneider Benjamin , Riedel Oliver , Bauer Wilhelm
Published: September 2022

Advanced Systems Engineering (ASE) is a paradigm for the efficient design and creation of tomorrow's products and services. Challenges, which the new paradigm addresses, are the increasing complexity of products and systems, increasing requirements from the regulatory side as well as the sustainability and manageability of the systems. Advanced Systems Engineering offers a variety of approaches for handling the requirements mentioned before. This paper focuses on supporting the handling of the increasing complexity and the requirements for sustainability of systems by the combined use of Model-based Systems Engineering (MBSE) and Artificial Intelligence (AI) in the early phase of product development. First, the paradigms and approaches ASE, MBSE, sustainability, and AI are presented. Subsequently, the current state of the art in the intersection of the described topics is explained in the context of a literature review. The methodology applied here follows the Systematic Literature Review approach. Based on this, potentials and white spots in research are identified and described. The paper concludes with recommendations for connecting to future research in the areas described.
Towards Designing Adaptive and Personalized Work Systems in Manufacturing
Authors: Schlund Sebastian , Kostolani David
Published: September 2022

Adaptation of work to humans instead of humans constantly adapting to work systems and work environments has been a goal of ergonomics since the 19th century. To date, an actual adaptation of work to the specific features, conditions and requirements of individual users has so far only taken place in rudimentary form. The possibilities have now opened up by the advances of Cyber Physical Production Systems (CPPS). This enables a renewed attempt to implement the goal of adapting work systems to workers. Integration of advanced sensory skills into work systems within manufacturing allows better recognition of the work environment and the actual state of the system. Together with actuator capabilities, it enables adaptive work systems to adjust their structure and behaviour to the anthropometric and the cognitive features and requirements of the systems’ users. However, a framework that integrates the concepts of adaptivity and personalization into the work system model and work system design is still missing. This paper explores the roots of adaptive and personalized human-machine systems and shows a framework for integrating these concepts into work systems and manufacturing. Based on this, exemplary works and implementations of individual systems are presented and placed in the overall context. The focus is set on implementations within the TU Wien Pilot Factory that cover adaptability concepts on workplace, process, and system level.
Simulation of combined heating for tumor ablation
Authors:   MIREA - Russian Technological University, 119454, Moscow, prospekt Vernadskogo, 78, Makarov V.N. , Boos N.A. ,   Firm «TECHNOSVET» LLC, 117342, Moscow, st. Vvedenskogo, 27-2-157
Published: September 2022

In the field of oncology therapy in the last few decades, methods of local thermal destruction have been intensively developed, which is heating a malignant neoplasm to a coagulation temperature and above. Among them, radiofrequency ablation (RFA) and microwave ablation (MWA) are the most common. The main problem of the existing MWA and RFA units is the insufficient degree of tissue coagulation. Depending on the type of tissue, various methods of exposure to an electromagnetic field can be used. In the radio frequency (RF) range, ohmic heating can be used, suitable for highly conductive tissues, and dielectric heating for low conductivity tissues. To increase the heating volume, it is proposed to combine ohmic and dielectric heating. The purpose of this work was to study the possibility of combining the processes of ohmic and dielectric heating based on methods of microwave and radiofrequency thermal destruction. A computer simulation of the combined heating electrode was carried out. The COMSOL Multiphysics software package was used to create the model. The algorithm for constructing the model consisted in creating the geometry, choosing the sizes of the working zones of the electrodes, setting the power parameters and imposing a finite element mesh. The model was two-dimensional. Various configurations of the combined heating electrode were considered. As a result, it was found that it is possible to create a heating area of a larger volume than with separate exposure. The overall shape of the resulting heating in all cases had an elliptical shape. At the same time, the heating pattern for RF working zones with a size of 5 mm had a shape more suitable for the treatment of spherical tumors than for working zones with a size of 10–20 mm. The results obtained demonstrate the possibility of increasing the heating volume by more than 40% compared to single operating modes. The most suitable sizes of RF heating zones are calculated, at which the heating volume will be maximum. The use of combined heating in clinical practice will partially solve the problems of insufficient heating volume inherent in the single-electrode heating mode in both RFA and MWA.
Colegios y producción de identidad jesuita
Authors: Dejo Juan
Published: September 2022

Gracias al modelo de oración en los Ejercicios Espirituales inspirado por la imaginación de escenas evangélicas, la Compañía de Jesús desarrolló una cultura religiosa ligada a la imagen. Su uso será el vehículo mediante el cual los jesuitas se representaron a sí mismos, clarificando el sentido de su misión e identidad. Así, sus Colegios y templos adyacentes fueron el espacio de una autorrepresentación que refleja, en distintas partes del mundo, un homogéneo programa iconográfico de cuatro dimensiones: a. la variedad de ministerios de la palabra, b. el carácter apostólico global, c. la propaganda institucional mediante la imagen martirial y d. la adaptación de sus miembros a las culturas locales, de modo especial, junto a las élites. Estos elementos pueden claramente apreciarse en el programa iconográfico del “Templo del Colegio de la Transfiguración del Cusco, Perú”.
bosquejo de las instituciones jesuitas de las Provincias de Perú y Paracuaria en 1767
Authors: Jackson Robert H.
Published: September 2022

En 1767, el rey Carlos III ordenó la expulsión de los jesuitas de todo el territorio español. El número total de jesuitas en Hispanoamérica fue tal vez de unos 2.600. A pesar del pequeño número, los jesuitas jugaron un papel importante en la sociedad colonial. Fueron importantes en la educación de los hijos de la élite urbana y en la vida espiritual de los habitantes de las ciudades. También administraban misiones fronterizas. Este artículo ofrece un panorama de las instituciones jesuitas en dos provincias, Perú y Paracuaria, ambas ubicadas en América del Sur, en 1767.
Experiences and Needs of Nurses Caring for COVID-19 Patients: A phenomenological Study
Authors: IŞIK Elif , ÇINAR ÖZBAY Sevil , YORULMAZ Deniz S.
Published: September 2022

Purpose: This study was conducted by using the qualitative study method descriptive phenomenological approach in order to explore the experiences and needs of nurses working during the COVID-19 pandemic.

Methods and Materials: This study was conducted using a descriptive phenomenological approach. The Questionnaire Form and the Semi-Structured Interview Form were used for data collection.

Results: Themes and sub-themes as a result of interviews with nurses were the effects of the pandemic (psychological effects, working conditions, social effects), fear and worries (stress and uncertainty, infecting beloved ones and others), satisfaction (motivation of being a nurse, care for patients with COVID-19 and interaction with them, team harmony and positive energy), needs(need for auxillary staff, need for additional nurses, need for psychological support), occupational health and safety (difficulties and pressures related to personal protective equipment, thermal comfort issues, nutritional problems, occupational accidents, relationship between COVID-19 and occupational disease).

Conclusion: Nurses who cared for patients diagnosed with COVID-19 in Turkey were negatively affected by the pandemic both psychologically and socially.
Two new species of the genus Cotoneaster Medik. (Rosaceae) from Armenia
Authors: Nersesyan A.
Published: September 2022

Two new species, Cotoneaster hajastanicus Nersesian sp. nova and C. zangezuricus Nersesian sp. nova, are described from Armenia. Both species belong to the section Cotoneaster.
Species of the genus Crataegus L. (Rosaceae) new to Russia
Authors: Ufimov R.
Published: September 2022

Three species of Crataegus new to the flora of Dagestan and Russia with their localities are listed. One species — C. tzvelevii Ufimov sp. nova — is described as a new one. Its differences from related species C. meyeri Pojark. and C. pentagyna Waldst. et Kit. ex Willd. are shown.
Taxonomical review of the genus Thompsonella Britton et Rose (Crassulaceae)
Authors: Byalt V.
Published: September 2022

A review of a small endemic Mexican genus Thompsonella Britton et Rose, which includes 8 species is given. The genus is for the first time subdivided into 3 sections: Thompsonella, Fruticulosae Byalt sect. nova and Reflexosepalae Byalt sect. nova. The key for the species identification, brief synonymy, morphological descriptions, information on types, ecology, phenology and geographical distribution of the species is given.
Konsep Dasar dan Ruang Lingkup Ekonomi Moneter Islam
Authors: R Nurul Zahra Zahirah
Published: September 2022

Resume ini untuk memenuhi tugas mata kuliah ekonomi moneter islam
Dental and Oral Care Model for Inpatients to Prevent the Occurrence of Hospital Acquired Pneumonia (HAP) in the Elderly in the Geriatric Room of Mukomuko Hospital Bengkulu Province
Authors: Sumarni Tim , Santoso Bedjo , Rasipin  , Sunarjo Lanny , Supriyadi
Published: September 2022

The cause of Hospital Acquired Pneumonia (HAP) is bacteria from dental plaque, colonizing with other pulmonary pathogens. This condition builds rational pathogen respiration in the oral cavity resulting in high-risk pneumonia. The risk group for HAP is over 70 years old, who have serious co-morbidities, malnutrition, decreased consciousness, and chronic obstructive pulmonary disease. Prevention of nosocomial infections requires integrated and programmed actions to reduce the transmission of organisms. This study aims to develop a model of dental and oral health care for inpatients to prevent the occurrence of HAP in the elderly. This study was conducted in the geriatric ward of Mukomuko Hospital, Bengkulu Province, Indonesia. The product test used a quasi-experimental pretest and posttest design. The sample of this study was each 16 respondents in the intervention group receiving dental and oral care and the control group receiving treatment as per the dental health national standard Indonesia Kepmenkes No.284, 2006. The results show that dental and oral care is relevant to prevent HAP with an average value of 88.4 (feasible) (p-value 0.001, and its application is effective in increasing knowledge (p=0.000) ),attitude (0.000), increased brushing skills (p = 0.000), gargle skills (p-value 0.000), decreased debris index score (p = 0.000), decreased CPIS respondents with (p = 0.000) and sputum culture results ( p = 0.000) compared to the control group. In conclusion, dental and oral health care can increase the skills of maintaining dental oral health, reduce the debris index and CPIS (Clinical Pulmonary Infection Score) for the elderly.
Konsep dasar ekonomi moneter
Authors: putri Aulia ananda
Published: September 2022

Dalam pengertian sederhana, ekonomi moneter merupakan salah satu rumpan ilmu ekonomi yang fokus perhatian dan analisisnya pada sifat, fungsi serta hubungan uang dalam semua aktivitas ekonomi makro. Lebih dalam lagi. Ekonomi moneter mempelajari bagaimana aktivitas uang yang mumpu memengaruhi semua aspek ekonomi dan pelakunya. Akan tetapi masih banyak sekali yang mampu dipelajari dari ekonomi moneter ini secara substansial, misalnya saja, bagaimana cara pasar uang bekerja dalam mengatur tingkat bunga, inflasi, dan mengatur kebijakan moneter, serta mengendalikan krisis finansial, hingga pada bagaimana mengendalikan sistem moneter internasional (Kuncoro, 2020).
Fisher information and metric flow
Authors: Vit Bytynaev
Published: September 2022

Duality information and metric flow
Whisper Sweet Nothings to Me Erdogan: How Economic Propaganda Works Under Authoritarianism
Authors: Öztürk Aykut
Published: September 2022

Most authoritarian regimes justify their rule based on economic performance. Yet, scholars are skeptical that authoritarian propaganda can increase performance evaluations. Through a case study of Turkey, combining qualitative, cross-sectional, and experimental analysis, this paper demonstrates that narrative-based economic propaganda can help electoral authoritarian regimes to preserve their support base even under difficult economic conditions. A national developmentalist narrative is central to the economic propaganda of Erdogan’s regime. I demonstrate that the belief in this narrative is widespread among regime voters, and it is strongly related to watching pro-regime media. The exposure to the developmentalist narrative improves economic evaluations among regime voters while also evoking partisan emotions. However, I do not find any effect of this narrative on other voters, demonstrating that narrative-based propaganda cannot help the regime to broaden its support base. This study contributes to the development of a cultural perspective on public opinion formation under authoritarian regimes.
Differential expression of SNX29P1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: September 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of SNX29P1, encoding sorting nexin 29 pseudogene 1, in primary fibroblasts of patients with sporadic ALS (sALS). SNX29P1 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with familial ALS. SNX29P1 transcript was present at significantly lower levels in sALS patient fibroblasts. These analyses will begin to define the transcriptional landscape of sporadic ALS.