bluuebunny/crossref_metadata_2025 huggingface dataset:
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Authors: Carnielli Carolina Moretto , Macedo Carolina Carneiro Soares , De Rossi Tatiane , Granato Daniela Campos , Rivera César , Domingues Romênia Ramos , Pauletti Bianca Alves , Yokoo Sami , Heberle Henry , Busso-Lopes Ariane Fidelis , Cervigne Nilva Karla , Sawazaki-Calone Iris , Meirelles Gabriela Vaz , Marchi Fábio Albuquerque , Telles Guilherme Pimentel , Minghim Rosane , Ribeiro Ana Carolina Prado , Brandão Thaís Bianca , de Castro Gilberto , González-Arriagada Wilfredo Alejandro , Gomes Alexandre , Penteado Fabio , Santos-Silva Alan Roger , Lopes Márcio Ajudarte , Rodrigues Priscila Campioni , Sundquist Elias , Salo Tuula , da Silva Sabrina Daniela , Alaoui-Jamali Moulay A. , Graner Edgard , Fox Jay W. , Coletta Ricardo Della , Paes Leme Adriana Franco
Published: August 2018

Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. Potential signature proteins are prioritized and further investigated by immunohistochemistry (IHC) and targeted proteomics. IHC indicates low expression of cystatin-B in neoplastic islands from the ITF as an independent marker for local recurrence. Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis.
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
Authors: Casar Berta , Badrock Andrew P. , Jiménez Iñaki , Arozarena Imanol , Colón-Bolea Paula , Lorenzo-Martín L. Francisco , Barinaga-Rementería Irene , Barriuso Jorge , Cappitelli Vincenzo , Donoghue Daniel J. , Bustelo Xosé R. , Hurlstone Adam , Crespo Piero
Published: August 2018

RAS GTPases are frequently mutated in human cancer. H- and NRAS isoforms are distributed over both plasma-membrane and endomembranes, including the Golgi complex, but how this organizational context contributes to cellular transformation is unknown. Here we show that RAS at the Golgi is selectively activated by apoptogenic stimuli and antagonizes cell survival by suppressing ERK activity through the induction of PTPRκ, which targets CRAF for dephosphorylation. Consistently, in contrast to what occurs at the plasma-membrane, RAS at the Golgi cannot induce melanoma in zebrafish. Inactivation of PTPRκ, which occurs frequently in human melanoma, often coincident with TP53 inactivation, accelerates RAS-ERK pathway-driven melanomagenesis in zebrafish. Likewise, tp53 disruption in zebrafish facilitates oncogenesis driven by RAS from the Golgi complex. Thus, RAS oncogenic potential is strictly dependent on its sublocalization, with Golgi complex-located RAS antagonizing tumor development.
Precipitation thresholds regulate net carbon exchange at the continental scale
Authors: Liu Zhihua , Ballantyne Ashley P. , Poulter Benjamin , Anderegg William R. L. , Li Wei , Bastos Ana , Ciais Philippe
Published: August 2018

Understanding the sensitivity of ecosystem production and respiration to climate change is critical for predicting terrestrial carbon dynamics. Here we show that the primary control on the inter-annual variability of net ecosystem carbon exchange switches from production to respiration at a precipitation threshold between 750 and 950 mm yr−1 in the contiguous United States. This precipitation threshold is evident across multiple datasets and scales of observation indicating that it is a robust result and provides a new scaling relationship between climate and carbon dynamics. However, this empirical precipitation threshold is not captured by dynamic global vegetation models, which tend to overestimate the sensitivity of production and underestimate the sensitivity of respiration to water availability in more mesic regions. Our results suggest that the short-term carbon balance of ecosystems may be more sensitive to respiration losses than previously thought and that model simulations may underestimate the positive carbon–climate feedbacks associated with respiration.
Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
Authors: Kang Myoung-Hee , Choi Hyunji , Oshima Masanobu , Cheong Jae-Ho , Kim Seokho , Lee Jung Hoon , Park Young Soo , Choi Hueng-Sik , Kweon Mi-Na , Pack Chan-Gi , Lee Ju-Seog , Mills Gordon B. , Myung Seung-Jae , Park Yun-Yong
Published: August 2018

The original version of this Article contained errors in Figs. 4, 5, and 6. In Fig. 4d, the x-axis label incorrectly read ‘blank, +, blank, +’, and in Fig. 5e, the bars of the second graph from the left were coloured blue-orange-blue-orange. Both of these errors have been fixed in the PDF and HTML versions of the Article. Furthermore, in Fig. 6a, the right-hand image of AGS cells treated with 5 µM DY131 was inadvertently replaced with a duplicate of the left-hand image. The correct version of this figure panel appears in the Author Correction associated with this Article. For transparency, the error has not been corrected in the PDF or HTML versions of the Article.
Understorey Rhododendron tomentosum and Leaf Trichome Density Affect Mountain Birch VOC Emissions in the Subarctic
Authors: Mofikoya Adedayo O. , Miura Kazumi , Ghimire Rajendra P. , Blande James D. , Kivimäenpää Minna , Holopainen Toini , Holopainen Jarmo K.
Published: August 2018

Subarctic vegetation is composed of mountain birch [Betula pubescens ssp. czerepanovii (MB)] forests with shrubs and other species growing in the understorey. The effects of the presence and density of one understorey shrub, Rhododendron tomentosum (RT), on the volatile emissions of MB, were investigated in a Finnish subarctic forest site in early and late growing season. Only MB trees with an RT-understorey emitted the RT-specific sesquiterpenoids, palustrol, ledol and aromadendrene. Myrcene, which is the most abundant RT-monoterpene was also emitted in higher quantities by MB trees with an RT-understorey. The effect of RT understorey density on the recovery of RT compounds from MB branches was evident only during the late season when sampling temperature, as well as RT emissions, were higher. MB sesquiterpene and total emission rates decreased from early season to late season, while monoterpene emission rate increased. Both RT and MB terpenoid emission rates were linked to density of foliar glandular trichomes, which deteriorated over the season on MB leaves and emerged with new leaves in the late season in RT. We show that sesquiterpene and monoterpene compounds emitted by understorey vegetation are adsorbed and re-released by MB, strongly affecting the MB volatile emission profile.
Discovery of topological nodal-line fermionic phase in a magnetic material GdSbTe
Authors: Hosen M. Mofazzel , Dhakal Gyanendra , Dimitri Klauss , Maldonado Pablo , Aperis Alex , Kabir Firoza , Sims Christopher , Riseborough Peter , Oppeneer Peter M. , Kaczorowski Dariusz , Durakiewicz Tomasz , Neupane Madhab
Published: August 2018

Topological Dirac semimetals with accidental band touching between conduction and valence bands protected by time reversal and inversion symmetry are at the frontier of modern condensed matter research. A majority of discovered topological semimetals are nonmagnetic and conserve time reversal symmetry. Here we report the experimental discovery of an antiferromagnetic topological nodal-line semimetallic state in GdSbTe using angle-resolved photoemission spectroscopy. Our systematic study reveals the detailed electronic structure of the paramagnetic state of antiferromagnetic GdSbTe. We observe the presence of multiple Fermi surface pockets including a diamond-shape, and small circular pockets around the zone center and high symmetry X points of the Brillouin zone (BZ), respectively. Furthermore, we observe the presence of a Dirac-like state at the X point of the BZ and the effect of magnetism along the nodal-line direction. Interestingly, our experimental data show a robust  Dirac-like state both below and above the magnetic transition temperature (TN  = 13 K). Having a relatively high transition temperature, GdSbTe provides an archetypical platform to study the interaction between magnetism and topological states of matter.
Relation between switching time distribution and damping constant in magnetic nanostructure
Authors: Moon Jung-Hwan , Lee Tae Young , You Chun-Yeol
Published: August 2018

It is widely known that the switching time is determined by the thermal stability parameters and external perturbations such as magnetic field and/or spin polarized current in magnetic nano-structures. Since the thermal stability parameter and switching time are crucial values in the design of spin-transfer torque magnetic random access memory, the measurement of the switching time is important in the study of the switching behavior of ferromagnetic nano-structures. In this study, we focus on the distribution of the switching time. Within the limit of a large energy barrier, a simple analytical expression between damping constant and anisotropy field with switching time distribution is obtained and confirmed by numerically solving the Fokker-Planck equation. We show that the damping constant and anisotropy field can be extracted by measuring the full width half maximum of the switching time distribution in the magnetic nano-structure devices. Furthermore, the present method can be applied to not only single nano-structure, but also inhomogeneous nano-structure arrays.
Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women
Authors: Nfor Oswald Ndi , Wu Ming-Fang , Lee Chun-Te , Wang Lee , Liu Wen-Hsiu , Tantoh Disline Manli , Hsu Shu-Yi , Lee Kuan-Jung , Ho Chien-Chang , Debnath Tonmoy , Lung Chia-Chi , Liaw Yung-Po
Published: August 2018

CDKAL1 rs10946398 is a type 2 diabetes (T2D)-associated variant. It is a new body mass index (BMI)-associated variant in Asian populations. We investigated the association between rs10946398 and T2D among 9908 participants aged 30–70 years based on BMI: normal weight; 18.5 ≤ BMI < 24 kg/m2, overweight; 24 ≤ BMI < 27 kg/m2, and obesity; BMI ≥27 kg/m2. The CC genotype conferred a higher risk of T2D than the CA genotype. The odds ratios (ORs) were 1.83; 95% confidence interval (CI) 1.49–2.26 and 1.20; 95% CI 1.02–1.40, respectively. The C allele was the significant risk allele compared with A allele (OR = 1.32; 95% CI 1.19–1.47). For normal, overweight and obese participants with CC genotype, the ORs were respectively 1.69; 95% CI 1.02–2.81, 2.34; 95% CI 1.50–3.66, and 1.58; 95% CI 1.02–2.45 among men and 1.22; 95% CI 0.67–2.22, 2.42; 95% CI 1.30–4.52, and 2.3; 95% CI 1.19–4.50 among women. The C allele ORs were higher in obese and overweight women. In conclusion, the rs10946398 CC/CA genotypes, as well as the C allele increased the risk of T2D. The ORs were higher in women who were overweight and obese than in those with normal weight. Nonetheless, significant results were prominent only among those with CC genotype and C allele.
Effects of Geometry on the Electronic Properties of Semiconductor Elliptical Quantum Rings
Authors: Vinasco J. A. , Radu A. , Kasapoglu E. , Restrepo R. L. , Morales A. L. , Feddi E. , Mora-Ramos M. E. , Duque C. A.
Published: August 2018

The electronic states in GaAs-AlxGa1−xAs elliptically-shaped quantum rings are theoretically investigated through the numerical solution of the effective mass band equation via the finite element method. The results are obtained for different sizes and geometries, including the possibility of a number of hill-shaped deformations that play the role of either connected or isolated quantum dots (hills), depending on the configuration chosen. The quantum ring transversal section is assumed to exhibit three different geometrical symmetries - squared, triangular and parabolic. The behavior of the allowed confined states as functions of the cross-section shape, the ring dimensions, and the number of hills-like structures are discussed in detail. The effective energy bandgap (photoluminescence peak with electron-hole correlation) is reported as well, as a function of the Al molar fraction.
Agricultural fungicides inadvertently influence the fitness of Colorado potato beetles, Leptinotarsa decemlineata, and their susceptibility to insecticides
Authors: Clements Justin , Schoville Sean , Clements Anna , Amezian Dries , Davis Tabatha , Sanchez-Sedillo Benjamin , Bradfield Christopher , Huseth Anders S. , Groves Russell L.
Published: August 2018

The Colorado potato beetle (CPB), Leptinotarsa decemlineata (Say), is an agricultural pest of solanaceous crops which has developed insecticide resistance at an alarming rate. Up to this point, little consideration has been given to unintended, or inadvertent effects that non-insecticide xenobiotics may have on insecticide susceptibility in L. decemlineata. Fungicides, such as chlorothalonil and boscalid, are often used to control fungal pathogens in potato fields and are applied at regular intervals when L. decemlineata populations are present in the crop. In order to determine whether fungicide use may be associated with elevated levels of insecticide resistance in L. decemlineata, we examined phenotypic responses in L. decemlineata to the fungicides chlorothalonil and boscalid. Using enzymatic and transcript abundance investigations, we also examined modes of molecular detoxification in response to both insecticide (imidacloprid) and fungicide (boscalid and chlorothalonil) application to more specifically determine if fungicides and insecticides induce similar metabolic detoxification mechanisms. Both chlorothalonil and boscalid exposure induced a phenotypic, enzymatic and transcript response in L. decemlineata which correlates with known mechanisms of insecticide resistance.
Impact of mangrove forests degradation on biodiversity and ecosystem functioning
Authors: Carugati Laura , Gatto Beatrice , Rastelli Eugenio , Lo Martire Marco , Coral Caterina , Greco Silvestro , Danovaro Roberto
Published: August 2018

Mangroves are amongst the most productive marine ecosystems on Earth, providing a unique habitat opportunity for many species and key goods and services for human beings. Mangrove habitats are regressing at an alarming rate, due to direct anthropogenic impacts and global change. Here, in order to assess the effects of mangrove habitat degradation on benthic biodiversity and ecosystem functioning, we investigated meiofaunal biodiversity (as proxy of benthic biodiversity), benthic biomass and prokaryotic heterotrophic production (as proxies of ecosystem functioning) and trophic state in a disturbed and an undisturbed mangrove forests. We report here that disturbed mangrove area showed a loss of 20% of benthic biodiversity, with the local extinction of four Phyla (Cladocera, Kynorincha, Priapulida, Tanaidacea), a loss of 80% of microbial-mediated decomposition rates, of the benthic biomass and of the trophic resources. The results of this study strengthen the need to preserve mangrove forests and to restore those degraded to guarantee the provision of goods and services needed to support the biodiversity and functioning of wide portions of tropical ecosystems.
Assessment of cerebral autoregulation using continuous-wave near-infrared spectroscopy during squat-stand maneuvers in subjects with symptoms of orthostatic intolerance
Authors: Kim Jae-Myoung , Choi Jong-Kwan , Choi Mingyu , Ji Minsu , Hwang Gunpil , Ko Sang-Bae , Bae Hyeon-Min
Published: August 2018

Orthostatic lightheadedness in healthy young adults often leads to syncope in severe cases. One suggested underlying mechanism of orthostatic lightheadedness is a drop in transient blood pressure (BP); however, a decrease in BP does not always lead to a drop in cerebral blood flow (CBF) due to cerebral autoregulation (CA). We present a direct assessment method of CA using a multichannel continuous-wave near-infrared spectroscopy (CW-NIRS) device that measures the temporal changes in oxy- and deoxy-hemoglobin concentrations in the prefrontal cortex. Twenty healthy young adults were recruited. During the experiment, continuous beat-to-beat BP and heart rate were simultaneously measured during repetitive squat-stand maneuvers. We introduce a new metric termed ‘time-derivative hemodynamic model (DHbT)’, which is the time-derivative of total-hemoglobin concentration change that reflects the changes of cerebral blood volume and CBF. Although the absolute levels and the variations of systolic and diastolic BPs and mean arterial pressure showed no significant difference between the two groups, the proposed model showed a distinct difference in slope variation and response time of DHbT between the subjects with frequent symptom of orthostatic intolerance and the healthy control subjects. Thus, these results clearly demonstrate the feasibility of using CW-NIRS devices as a CA performance assessment tool.
Cardiac resynchronization therapy: a comparison among left ventricular bipolar, quadripolar and active fixation leads
Authors: Ziacchi M. , Diemberger I. , Corzani A. , Martignani C. , Mazzotti A. , Massaro G. , Valzania C. , Rapezzi C. , Boriani G. , Biffi M.
Published: August 2018

We evaluated the performance of 3 different left ventricular leads (LV) for resynchronization therapy: bipolar (BL), quadripolar (QL) and active fixation leads (AFL). We enrolled 290 consecutive CRTD candidates implanted with BL (n = 136) or QL (n = 97) or AFL (n = 57). Over a minimum 10 months follow-up, we assessed: (a) composite technical endpoint (TE) (phrenic nerve stimulation at 8 V@0.4 ms, safety margin between myocardial and phrenic threshold <2V, LV dislodgement and failure to achieve the target pacing site), (b) composite clinical endpoint (CE) (death, hospitalization for heart failure, heart transplantation, lead extraction for infection), (c) reverse remodeling (RR) (reduction of end systolic volume >15%). Baseline characteristics of the 3 groups were similar. At follow-up the incidence of TE was 36.3%, 14.3% and 19.9% in BL, AFL and QL, respectively (p < 0.01). Moreover, the incidence of RR was 56%, 64% and 68% in BL, AFL and QL respectively (p = 0.02). There were no significant differences in CE (p = 0.380). On a multivariable analysis, “non-BL leads” was the single predictor of an improved clinical outcome. QL and AFL are superior to conventional BL by enhancing pacing of the target site: AFL through prevention of lead dislodgement while QL through improved management of phrenic nerve stimulation.
Simple and rational design of a polymer nano-platform for high performance of HCV related miR-122 reduction in the liver
Authors: Fu Hao , Zhang XiangYu , Wang Qi , Sun Yin , Liu Lei , Huang LiLi , Ding Li , Shen Ming , Zhang Lin , Duan Yourong
Published: August 2018

Efficient long-term liver specific miR-122 reduction is achieved by utilizing high antagomir loading capacity NPs consisting of an mPEG-b-PLGA-b-PLL triblock copolymer.
Light-activatable Chlorin e6 (Ce6)-imbedded erythrocyte membrane vesicles camouflaged Prussian blue nanoparticles for synergistic photothermal and photodynamic therapies of cancer
Authors: Sun Lihong , Li Qian , Hou Mengmeng , Gao Ya , Yang Ruihao , Zhang Lei , Xu Zhigang , Kang Yuejun , Xue Peng
Published: August 2018

Camouflaged Prussian blue nanoparticles for laser-activated bimodal tumor therapy.
DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection
Authors: Shi Liu , Mu Chaoli , Gao Tao , Chen Tianshu , Hei Shuang , Yang Jie , Li Genxi
Published: August 2018

DNA nanoflower blooming was employed in the nanochannels of porous anodic alumina to build a nanochannel platform for miRNA detection with excellent sensitivity, selectivity and reproducibility.
Palladium-catalyzed aerobic oxidative carbonylation of alkynes with amines: a general access to substituted maleimides
Authors: Yang Ji , Liu Jiawang , Jackstell Ralf , Beller Matthias
Published: August 2018

A catalytic oxidative carbonylation reaction was developed for the synthesis of polysubstituted maleimides from alkynes and amines with air as a green oxidant.
Copper-catalyzed tandem aerobic oxidative cyclization for the synthesis of 4-cyanoalkylpyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclobutanone oxime esters
Authors: An Zhenyu , Jiang Yong , Guan Xin , Yan Rulong
Published: August 2018

A copper-catalyzed tandem ring-opening/cyclization reaction for the synthesis of 4-cyanoalkylpyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclobutanone oxime esters has been developed.
Enhancement of lithium-ion hopping on halogen-doped χ3 borophene
Authors: Xia Zihan , Chen Xianfei , Zhang Wentao , Li Junfeng , Xiao Beibei , Du Haiying
Published: August 2018

Incorporation of halogen atom in χ3 borophene could facilitate lithium-ion hopping and improve its rate performance as anode material.
Ab initio molecular dynamics studies of formic acid dimer colliding with liquid water
Authors: Hänninen Vesa , Murdachaew Garold , Nathanson Gilbert M. , Gerber R. Benny , Halonen Lauri
Published: August 2018

Ab initio molecular dynamics simulations of formic acid (FA) dimer colliding with liquid water at 300 K have been performed using density functional theory.
On the formation and the isomer specific detection of methylacetylene (CH3CCH), propene (CH3CHCH2), cyclopropane (c-C3H6), vinylacetylene (CH2CHCCH), and 1,3-butadiene (CH2CHCHCH2) from interstellar methane ice analogues
Authors: Abplanalp Matthew J. , Góbi Sándor , Kaiser Ralf I.
Published: August 2018

The isomer specific detection of complex hydrocarbons from irradiated methane ice plus their yields and formation routes have been elucidated.
Degradation of leachate from a semi-anaerobic aged refuse biofilter by the ZVI/H2O2 process coupled with microwave irradiation: optimization, organics transformation, and reaction mechanisms
Authors: Zhang Aiping , Gu Zhepei , Chen Weiming , Li Qibin
Published: August 2018

The semi-aerobic aged refuse biofilter (SAARB) is highly efficient in removing organic matter and ammonia nitrogen, but the effluent of the SAARB (SAARB leachate) contains high concentrations of recalcitrant organics.
Zirconium permanent modifiers for graphite furnaces used in absorption spectrometry: understanding their structure and mechanism of action
Authors: Abad Carlos , Florek Stefan , Becker-Ross Helmut , Huang Mao-Dong , Buzanich Ana Guilherme , Radtke Martin , Lippitz Andreas , Hodoroaba Vasile-Dan , Schmid Thomas , Heinrich Hans-Joachim , Recknagel Sebastian , Jakubowski Norbert , Panne Ulrich
Published: August 2018

The mechanism of action of zirconium permanent modifiers on graphite surfaces was investigated in order to understand its influence on the analytical signal in atomic and molecular absorption spectrometry (AAS/MAS).
Improved power conversion efficiency of perovskite solar cells using highly conductive WOx doped PEDOT:PSS
Authors: Kanwat Anil , Rani V. Sandhya , Jang Jin
Published: August 2018

Poly(3,4-thylenedioxythiophene):poly(styrene sulfonate), PEDOT:PSS, is a popular and cost effective conducting polymer for electrodes that can also be used as a hole transport layer (HTL) in optoelectronics.
Ultrafast fabrication of nickel sulfide film on Ni foam for efficient overall water splitting
Authors: Ren Gang , Hao Qiuyan , Mao Jing , Liang Limin , Liu Hui , Liu Caichi , Zhang Jun
Published: August 2018

Ni3S2 films grown on Ni foam by directly wetting with mercaptoethanol work as an efficient bifunctional electrode for overall water splitting.
Phosphazene-catalyzed oxa-Michael addition click polymerization
Authors: Yang Hongjun , Zuo YongKang , Zhang Jiadong , Song Yiye , Huang Wenyan , Xue Xiaoqiang , Jiang Qimin , Sun Aibin , Jiang Bibiao
Published: August 2018

This paper reports a new type of click chemistryviaa phosphazene bases-catalyzed oxa-Michael addition of an alcohol to an acrylate.
Efficient heterogeneous catalysis by dual ligand Zn(ii)/Cd(ii) MOFs for the Knoevenagel condensation reaction: adaptable synthetic routes, characterization, crystal structures and luminescence studies
Authors: Parmar Bhavesh , Patel Parth , Murali Vishnu , Rachuri Yadagiri , Kureshy Rukhsana I. , Khan Noor-ul H. , Suresh Eringathodi
Published: August 2018

Chemically stable Zn(ii)/Cd(ii) MOFs as a heterogeneous catalysts for Knoevenagel condensation.
Carve designs of MoS2 nanostructures by controlling 3D MoS2 nanomasks
Authors: Liu Zechen , Xiao Dingbin , Huang Hongyang , Zhang Jinying , Niu Chunming
Published: August 2018

A carved MoS2 nanostructure has been produced by controlling an in situ grown three-dimensional MoS2 nanomask.
A NaSO2CF3/NaBrO3-mediated bromotrifluoromethylation of enyne via free-radical cascade processes
Authors: Shang Xiao-Jie , Liu Dong , Liu Zhong-Quan
Published: August 2018

A NaBrO3-induced radical bromotrifluoromethylation of enynes with NaSO2CF3 was developed. This method allows a transition-metal free, highly selective and step-economic access to diverse bromotrifluoromethylated five- and six-membered heterocycles.
Towards cancer diagnostics – an α-feto protein electrochemical immunosensor on a manganese(iv) oxide/gold nanocomposite immobilisation layer
Authors: Idris Azeez O. , Mabuba Nonhlangabezo , Arotiba Omotayo A.
Published: August 2018

A novel electrochemical immunosensor for the quantification of α-feto protein (AFP) using a nanocomposite of manganese(iv) oxide nanorods (MnO2NRs) and gold nanoparticles (AuNPs) as the immobilisation layer is presented.
Activity-based ubiquitin-protein probes reveal target protein specificity of deubiquitinating enzymes
Authors: Gong Ping , Davidson Gregory A. , Gui Weijun , Yang Kun , Bozza William P. , Zhuang Zhihao
Published: August 2018

Activity-based Ub-PCNA probes identify deubiquitinating enzymes (DUBs) specific for PCNA and demonstrate site-specific deubiquitination by DUBs.
Alternating oligo(o,p-phenylenes) via ruthenium catalyzed diol–diene benzannulation: orthogonality to cross-coupling enables de novo nanographene and PAH construction
Authors: Kasun Zachary A. , Sato Hiroki , Nie Jing , Mori Yasuyuki , Bender Jon A. , Roberts Sean T. , Krische Michael J.
Published: August 2018

Ruthenium(0) catalyzed diol–diene benzannulation enables formation of p-bromo-terminated alternating oligo(o,p-phenylenes) and, therefrom, diverse PAH materials.
Double layer 3D codes: fluorescent supramolecular polymeric gels allowing direct recognition of the chloride anion using a smart phone
Authors: Ji Xiaofan , Chen Wei , Long Lingliang , Huang Feihe , Sessler Jonathan L.
Published: August 2018

The top layer of a two-layer 3D code can be delaminated and removed by exposure to a chloride anion source.
Glucose isomerization catalyzed by bone char and the selective production of 5-hydroxymethylfurfural in aqueous media
Authors: Matsagar Babasaheb M. , Van Nguyen Chi , Hossain Md. Shahriar A. , Islam Md. Tofazzal , Yamauchi Yusuke , Dhepe Paresh L. , Wu Kevin C.-W.
Published: August 2018

Glucose isomerization and selective production of 5-hydroxymethylfurfural in aqueous media, using combined catalysis of bone char and acidic ionic liquid.
From 2D to 3D: a facile and effective procedure for fabrication of planar CH3NH3PbI3perovskite solar cells
Authors: Zhang Yu , Li Fengzhu , Jiang Ke-Jian , Huang Jin-Hua , Wang Huijia , Fan Haochen , Wang Pengcheng , Liu Cai-Ming , Zhang Li-Peng , Song YanLin
Published: August 2018

2D organic–inorganic hybrid perovskite single crystal (n-C3H7NH3)6Pb4I14was synthesized, and converted into 3D CH3NH3PbI3perovskiteviaorganic-cation displacement. Using the film as a light absorber, planar perovskite solar cells were fabricated with the best power conversion efficiency of 19.19%.
Enhancement of synthesis of extracellular matrix proteins on retinoic acid loaded electrospun scaffolds
Authors: Damanik Febriyani F. R. , van Blitterswijk Clemens , Rotmans Joris , Moroni Lorenzo
Published: August 2018

Electrospinning was used to create scaffolds able to release retinoic acid in a controlled manner, which resulted in enhanced extracellular matrix production.
Polymersome–hydrogel composites with combined quick and long-term antibacterial activities
Authors: Hong Yuanxiu , Xi Yuejing , Zhang Junxue , Wang Dongdong , Zhang Hailong , Yan Ning , He Shisheng , Du Jianzhong
Published: August 2018

Intrinsically antibacterial polymersomes loaded with antibiotics were incorporated into hydrogels, exhibiting quick and long-acting antibacterial activity.
Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics
Authors: Yan Shufeng , Chen Jincan , Cai Liangzhi , Xu Peng , Zhang Yaxin , Li Shijie , Hu Ping , Chen Xueyuan , Huang Mingdong , Chen Zhuo
Published: August 2018

A versatile phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics.
ortho-Fluorination of azophenols increases the mesophase stability of photoresponsive hydrogen-bonded liquid crystals
Authors: Saccone Marco , Kuntze Kim , Ahmed Zafar , Siiskonen Antti , Giese Michael , Priimagi Arri
Published: August 2018

We present a photoresponsive supramolecular liquid-crystalline (LC) system with enhanced stability of the LC phase due to ortho-fluorination of the bond-donating hydroxyazobenzene derivative, an important characteristic for their future use in photonics.
Isomeric spiro-[acridine-9,9′-fluorene]-2,6-dipyridylpyrimidine based TADF emitters: insights into photophysical behaviors and OLED performances
Authors: Ganesan Paramaguru , Chen Deng-Gao , Liao Jia-Ling , Li Wei-Cheng , Lai Yi-Ning , Luo Dian , Chang Chih-Hao , Ko Chang-Lun , Hung Wen-Yi , Liu Shun-Wei , Lee Gene-Hsiang , Chou Pi-Tai , Chi Yun
Published: August 2018

TADF molecules with various dipyridylpyrimidine acceptors are synthesized and exhibited a max. EQE of 14.1% for a non-doped OLED device architecture.
Rational synthesis of organic single-crystalline microrods and microtubes for efficient optical waveguides
Authors: Zhuo Ming-Peng , Tao Yi-Chen , Wang Xue-Dong , Chen Shuo , Liao Liang-Sheng
Published: August 2018

Binary organic DPEpe–F4DIB single-crystalline microrods and microtubes were controllably prepared using a facile solution evaporation method in different solvent systems. The microtubes display a lower optical-loss of 0.0145 dB μm−1 than that of 0.0341 dB μm−1 for the microrods.
Broadband quad‐polarisation reconfigurable antenna
Authors: Cui Y.H. , Zhang P.P. , Li R.L.
Published: August 2018

A new broadband quad‐polarisation reconfigurable antenna is proposed. The reconfigurable antenna consists of a +45° polarised dipole and a −45° polarised dipole. Each dipole is excited by a broadband balun. A reconfigurable feeding network is employed to feed the ±45° polarised dipoles. When the ±45° polarised dipoles are separately fed, ±45° linear polarisations are obtained. As the ±45° polarised dipoles are simultaneously fed with a +90° or −90° phase difference, left‐handed circular polarisation (CP) or right‐handed CP is asserted. It is shown by simulation and experiment that the quad‐polarisation reconfigurable antenna achieves an overlapped impedance bandwidth of 37% (0.69–1.0 GHz) for return loss >15 dB and an overlapped bandwidth of 36% (0.66–0.95 GHz) for axial ratio <3 dB.
Video-Assisted Thoracoscopic Surgery for Pulmonary Sequestrations: Series of 35 Consecutive Patients in a Single Center
Authors: Wang Shaodong , Li Yun , Wang Jun
Published: August 2018

Objective The aim of this report is to summarize the experience of completely video-assisted thoracoscopic surgery (VATS) for pulmonary sequestration in a single center and to evaluate the long-term outcome in a larger series of patients.

Methods The data of 35 pulmonary sequestrations who received completely VATS consecutively in Peking University People's Hospital between January 2008 and November 2017 were retrospectively reviewed. Twenty-three females and twelve males with an average of 38 years old were included.

Results A total of 28 (80%) patients had preoperative symptoms; leading symptoms were recurrent infections (22), fever (11), hemoptysis (11), chest pain (9), and shortness of breath (4). Twenty-nine (82.9%) patients were intralobar pulmonary sequestration (22 in the left lower lobe, 6 in the right lower lobe, and 1 in the left upper lobe) and six (17.1%) patients were extralobar pulmonary sequestration. All the patients underwent VATS excision successfully, 26 underwent lobectomy, 2 underwent wedge resection, 1 underwent occlusion of the aberrant artery, and 6 underwent mass resection in all of those with extralobar pulmonary sequestration. The median surgery time and estimated blood loss was 150 (75–300) minutes and 50 (10–600) mL, respectively. There was no mortality. Only one patient suffered postoperative complication (recurrent laryngeal nerve injury). During the median follow-up period of 57 months, none of the patients presented recurrence.

Conclusions Completely VATS was a safe and effective mini-invasive procedure for pulmonary sequestration in an experienced team. Its long-term outcome was remarkable.
Numerical and closed-form solutions for the Maxwell equations of incompressible flow
Authors: Thompson Richard , Moeller Trevor
Published: August 2018

The equations of fluid dynamics governing an incompressible flow may be recast into the form of a set of Maxwell equations for the Lamb vector and vorticity, which play a role analogous to the electric and magnetic fields, respectively. The challenge in utilizing this approach is that analogous source terms, analogous to the charge density and current density, must be known in order to solve the Maxwell equations directly. In this paper, we explore the construction of source terms for laminar incompressible flow. To demonstrate the utility of this approach, we use the newly formed source terms and demonstrate that common mathematical techniques may be borrowed from classical electrodynamics and used to solve the fluid Maxwell system. We illustrate the approaches using the classic nonlinear problem of the incompressible Blasius boundary layer flow. Four different methods commonly used in electrostatics are applied to arrive at numerical and closed-form solutions of the Blasius boundary layer flow. The results compare very well to the accepted solution and to each other.
Defects responsible for charge carrier removal and correlation with deep level introduction in irradiated β-Ga2O3
Authors: Polyakov A. Y. , Smirnov N. B. , Shchemerov I. V. , Yakimov E. B. , Pearton S. J. , Fares Chaker , Yang Jiancheng , Ren Fan , Kim Jihyun , Lagov P. B. , Stolbunov V. S. , Kochkova A.
Published: August 2018

Carrier removal rates and electron and hole trap densities in β-Ga2O3 films grown by hydride vapor phase epitaxy (HVPE) and irradiated with 18 MeV α-particles and 20 MeV protons were measured and compared to the results of modeling. The electron removal rates for proton and α-radiation were found to be close to the theoretical production rates of vacancies, whereas the concentrations of major electron and hole traps were much lower, suggesting that the main process responsible for carrier removal is the formation of neutral complexes between vacancies and shallow donors. There is a concurrent decrease in the diffusion length of nonequilibrium charge carriers after irradiation, which correlates with the increase in density of the main electron traps E2* at Ec − (0.75–0.78) eV, E3 at Ec − (0.95–1.05) eV, and E4 at Ec − 1.2 eV. The introduction rates of these traps are similar for the 18 MeV α-particles and 20 MeV protons and are much lower than the carrier removal rates.
Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction
Authors: Hinrichs Svenja , Scherschel Katharina , Krüger Saskia , Neumann Johannes Tobias , Schwarzl Michael , Yan Isabell , Warnke Svenja , Ojeda Francisco M. , Zeller Tanja , Karakas Mahir , Keller Till , Meyer Christian , Blankenberg Stefan , Westermann Dirk , Lindner Diana
Published: August 2018

Significance

Myocardial infarction (MI) is one of the leading causes of death worldwide and is characterized by apoptosis and inflammation. While increased adrenomedullin (ADM) levels after MI are associated with disease severity, ADM infusion leads to antiapoptotic effects, suggesting a self-protective mechanism. ADM is cleaved from a full‐length precursor protein (ProADM), a putatively inactive prohormone. Our data show that ProADM is biologically active by reducing apoptosis to a similar extent as ADM. In contrast to ADM, ProADM has proinflammatory effects on cardiac fibroblasts but antiinflammatory effects on activated leukocytes. We assume that ProADM induces local inflammation but attenuates exaggerated inflammation. Our data suggest that both proteins are beneficial during MI by regulating inflammation and reducing apoptosis of cardiomyocytes.
Nontrivial superconductivity in topological MoTe

2−
x

S

x

crystals
Authors: Li Yanan , Gu Qiangqiang , Chen Chen , Zhang Jun , Liu Qin , Hu Xiyao , Liu Jun , Liu Yi , Ling Langsheng , Tian Mingliang , Wang Yong , Samarth Nitin , Li Shiyan , Zhang Tong , Feng Ji , Wang Jian
Published: August 2018

Significance

Searching for topological superconductors is of paramount importance in condensed-matter physics and materials science today: these materials are expected to harbor Majorana fermions on the edge states, an essential component for topological quantum computation platform. We experimentally observed
s
+−
pairing two-gap superconductivity and type-II Weyl semimetal property in

T
d

-phase MoTe

2−
x

S

x

(
x
≈ 0.2). Further, an enhanced surface superconducting gap comparing to bulk gaps is discovered. Our findings are strongly suggestive of topological superconductivity of the

T
d

-phase MoTe

2−
x

S

x

. This work not only presents an important breakthrough in searching for topological superconductors but also inspires further investigations on the sign-change superconductivity beyond Fe-based high-T
c
superconductors.
The kaleidoscope of divine images
Authors: Huang Wen-Yi , Chiang Wen-yu
Published: August 2018

Compared to metaphors about God in the Bible, those in other Christian contexts seem to receive little academic attention. To bridge this gap, this study examines metaphors gathered from gospel songs on Billboard and iTunes to analyze the abstract concept of God from a cognitive linguistic viewpoint through extending the framework of Conceptual Metaphor Theory. Our findings indicate that while diverse kinds of metaphors focus on the multi-dimensionality of God such as his characteristics (e.g., GOD IS A MAGICIAN and GOD IS A LOVER), outline (e.g., GOD IS A CONTAINER and GOD IS LIQUID), and supreme status (e.g., GOD IS HIGH), structural metaphors tend to represent the overwhelming majority and thus form the basis for the structural-metaphor-dominant phenomenon. In addition, the flawless figure of God is suggested to result from the PERFECTION image schema which is responsible for hidden aspects in related metaphorical structures. Furthermore, metaphors about divine images, having their mapping details enriched by biblical context, are suggested to possess recessive metaphor inheritance. Finally, the rhythm of ‘chain of metaphors’ is proposed to interpret how the spirit of the songs about the divine being are brought out. This study sheds light on our overall understanding of the concepts of God in Christian culture, and contributes to the development of interdisciplinary studies concerning metaphor, religion, cognition, and culture.
One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels
Authors: Yau Michael C. , Kim Robin Y. , Wang Caroline K. , Li Jingru , Ammar Tarek , Yang Runying Y. , Pless Stephan A. , Kurata Harley T.
Published: August 2018

Retigabine is an antiepileptic drug and the first voltage-gated potassium (Kv) channel opener to be approved for human therapeutic use. Retigabine is thought to interact with a conserved Trp side chain in the pore of KCNQ2–5 (Kv7.2–7.5) channels, causing a pronounced hyperpolarizing shift in the voltage dependence of activation. In this study, we investigate the functional stoichiometry of retigabine actions by manipulating the number of retigabine-sensitive subunits in concatenated KCNQ3 channel tetramers. We demonstrate that intermediate retigabine concentrations cause channels to exhibit biphasic conductance–voltage relationships rather than progressive concentration-dependent shifts. This suggests that retigabine can exert its effects in a nearly “all-or-none” manner, such that channels exhibit either fully shifted or unshifted behavior. Supporting this notion, concatenated channels containing only a single retigabine-sensitive subunit exhibit a nearly maximal retigabine effect. Also, rapid solution exchange experiments reveal delayed kinetics during channel closure, as retigabine dissociates from channels with multiple drug-sensitive subunits. Collectively, these data suggest that a single retigabine-sensitive subunit can generate a large shift of the KCNQ3 conductance–voltage relationship. In a companion study (Wang et al. 2018. J. Gen. Physiol. https://doi.org/10.1085/jgp.201812014), we contrast these findings with the stoichiometry of a voltage sensor-targeted KCNQ channel opener (ICA-069673), which requires four drug-sensitive subunits for maximal effect.
Materials from mathematics
Authors: James Richard
Published: August 2018

I survey some examples of materials whose recent discovery was based in an essential way on mathematical ideas. The main idea concernscompatibility, the fitting together of the phases of a material. Some of the emerging materials have the ability to change heat directly into electricity without the need of a separate electrical generator.
The History of Reading in Australia
Authors: Buckridge Patrick
Published: August 2018

A history of reading in Australia needs to go beyond the question of what Australians have read in the course of their history (though this question in itself is important) to tackle the more elusive question of how they have read. This question implies a recognition that reading is not a single, uniform activity but a congeries of “literate techniques” that are spread unevenly across the reading population at any given moment, and that are themselves subject to evolution and change as new cultural, political, and educational pressures exert their influence on how people read. The multiplicity and heterogeneity of reading practices are especially evident in the first half of the 20th century, particularly between World War I and World War II when reading itself came to be problematized as never before by the rise of advertising, cinema, popular culture, and political propaganda. It is important too to consider the ways in which reading as an institution in its own right, something above and beyond both the texts being read and the activity of reading them, has developed historically. Here the question is not so much what people have read, or how, but why. What values—positive and negative—have been attributed to reading, by whom, and in association with what social ideals, purposes, and anxieties? Also relevant here is the changing place of reading in Australian society more broadly. In particular, its changing relationship with writing as a valued component of Australian culture is of interest.
The Korean War and Its Literary Legacies
Authors: Kim Daniel Y.
Published: August 2018

Since the late 1990s, a growing number of US authors has been drawn to the Korean War, hoping to undo its status as “The Forgotten War.” The fact that it has served as the focus of novels by eminent Korean American authors like Chang-rae Lee and Susan Choi is not entirely surprising, given that they are the children of immigrants whose early lives had been shaped by the conflict. Given the extraordinarily high number of civilian deaths that resulted from the war and the many families that were fractured, the war is clearly a defining event that helped create a Korean diaspora. It has also become the focus, however, of novels by non-Korean American authors, including Toni Morrison, Rolando Hinojosa, and Ha Jin, which testifies to the fact that it was an event in which a number of domestic histories of race and transnational histories of empire converged. The body of literary works that have emerged around this event can be thought of as constituting an archive of what Michael Rothberg has termed “multidirectional memory,” one that suggests the intimacies of multiple histories involving not only Koreans and Korean Americans, but also other US racialized groups including African, Mexican, Chinese, and Japanese Americans as well as their connections to the complicated formations of empire that have shaped the relationships between Asian nations. Contending with the complexity and range of literary works that have centered on this event enables a reconsideration and expansion of what the proper subjects and objects of Asian American literary criticism are. If the field has outgrown its origins, in which the projection of a cultural nationalist vision of Asian American identity was a paramount goal, the vibrancy of these works stems from their soundings of a subject that is not univocal but multivocal. The political desires they seek to animate in their readers are not reducible to an agenda of combating domestic racism or consolidating a nativist notion of Asian American cultural identity, though they may contribute to such endeavors. More expansively, however, they articulate a multivalent range of progressive political aspirations and proliferate an array of identificatory possibilities.
Four Theories of the Press
Authors: Nerone John
Published: August 2018

Siebert, Peterson, and Schramm’s Four Theories of the Press has been a powerful influence on scholarship on comparative press systems and normative press theories in the years since its publication in 1956. Its appeal comes from the way it combined a history of Western development with a normative schema that is simple and teachable. Critics have pointed out the shortcomings of both its historical accounts and its theoretical structure, charging that the book expressed a Cold War mentality, elided non-Western and nonliberal theories and practices, and neglected the complicating dimensions of race, class, gender, and ethnicity. Critics also note that actual press systems are usually governed by hybrid norms, and that press systems are increasingly interconnected, overlapping, and global. Yet, Four Theories of the Press retains significant influence despite these criticisms. One reason is that no real replacement has appeared and it is unlikely that a new map of normative theories will win acceptance. The work emerged at a unique moment of Western liberal global hegemony and a successor would require a similar hegemonic moment.