bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Travel Distance in a Synchronized-Zone Order Picking System: A Mathematical Programming Approach
Authors: Alnashmy Majedah
Published: February 2024

This paper offers an integrated approach for correlated storage assignment strategy (CSAS) to optimize travel distance by considering item correlation, picking frequency, zoning, and slot constraints to improve operational efficiency in distribution centers. We simplify the mixed integer non-linear programming (MINLP) model and incorporate integrated heuristic procedures for faster convergence. We introduce positive and negative centroid deviations as techniques to guide the model convergence and explore different scenarios. In the second stage of item assignment, we prioritize items within zones using a ranking formula that is optimal for both single-item and multiple-item orders. By analyzing the distribution of correlated item across zones and the impact of their picking frequency on optimizing travel distance, we propose an improved CSAS that minimize travel distance by strategically placing items based on their proximity to the depot. Our model reduces trips in distant zones by prioritizing larger average order sizes, while maximizing trips for frequently ordered smaller lists in closer zones. This method significantly reduces travel distance by minimizing the need for pickers in distant zones to frequently travel to the depot. Simulation results show reductions of up to 36.75% for fitted data and 33.59% for recent data.
Transient and dynamic simulation of the fluid flow through 5-way Electric Coolant Control valve of 100kW Fuel Cell Vehicle by CFD with Moving-grids Technique
Authors: Jeong Soo-Jin , Kang Jihoon , Moon Seong-Joon , Lee Gumsu
Published: February 2024

The aim of this study is to investigate transient dynamic flow characteristics of the fluid flow through 5-way electric coolant valve (PCCV : Penta-Control Coolant Valve). To achieve this goal, the present paper attempts the three-dimensional dynamic simulation of the fluid flow through the valve using a commercial CFD solver with moving mesh technique to consider flow inertia and dynamic flow in the opening and closing stages of the ball valve rotating motion. Firstly, dynamic flow characteristics and the thermal mixing inside the PCCV ball valve during the opening and closing stage was analyzed. It is found that the discrepancies between dynamic and steady state simulation is remarkable when fluxes with different levels of enthalpy and momentum flow into the PCCV leads to strong flow interference and flow inertia, while the discrepancies are relatively small at low rotation speed and weak flow interference. Then, the effect of dynamic flow characteristics of the valve on dynamic thermal mixing characteristics at two different ball valve rotational speeds and rotational directions were investigated. It was found that the dynamic flow and thermal mixing characteristics inside the PCCV are greatly affected by the rotation speed, rotation direction, and degree of flow interference between fluxes. It is helpful for the design of the better coolant control strategies and the improvement of the FCEV thermal management system.
The Backgrounds of Renaissance Paintings in the Ancient Duchy of Ur-Bino (Central Italy): Exploring New Forms of Valorization of Geoheritage through Their Inclusion in UNESCO Cultural Landscapes
Authors: Nesci Olivia , Borchia Rosetta , Valentini Laura
Published: February 2024

The ancient Duchy of Urbino (Marche and Emilia-Romagna Regions, Italy) is known for its spectacular landscapes linked to a unique geological history. This area owns an unexpected cultural resource, which concerns using its landscapes in art. Some great Renaissance artists, including Piero della Francesca, Raphael, and Leonardo, were so impressed by the landscapes that they reproduced them in their most famous paintings.
This paper summarizes research concerned with their identification, employing a multidisciplinary method that has enabled the recognition of many morphologies. This contribution provides the scientific community with information on the methodology and regional and national projects developed in this area to enhance its cultural landscapes.
Starting from the geological description of the territory, the research focuses on famous works by three great Renaissance artists, providing evidence and morphological details related to the recognition of places: “Nativity” by Piero della Francesca, “Madonna Litta” by Leonardo da Vinci and “Knight’s Dream” by Raphael. Finally, it is proposed to make these landscapes a timeless resource through their inclusion in UNESCO’s cultural heritage.
This contribution is addressed to representatives of the administration, conservation, and enhancement of artistic and landscape heritage to stimulate new perspectives for research, education, and tourism within the cultural heritage of this area.
Targeting the Bcr-Abl Oncoprotein in Leukemia: Molecular Docking Analysis and Toxicity Prediction of Potential Therapeutic Candidates
Authors: Ferrari Ivan Vito
Published: February 2024

The study focused on Molecular Docking simulations using Autodock Vina in conjunction with the Pyrx program to investigate potential drugs and natural compounds against the Bcr-Abl oncoprotein. From initial virtual screening of 200 compounds, 11 potential candidates were selected for further evaluation. Additional investigations included toxicity prediction using the pKCSM server. Among the compounds, Diosmin and Hesperidin showed high maximum tolerated doses in humans and low toxicity. Conversely, only Eltrombopag among the selected drugs exhibited excellent parameters, albeit with a potential risk of liver damage at high dosages. These findings underscore the need for comprehensive evaluation of efficacy and safety in the development of potential treatments targeting the Bcr-Abl oncoprotein.
Process Analysis and Modelling of Operators Performance in Classical and Digitalized Assembly Workstations
Authors: NEACŞU (DOBRIŞAN) Georgiana Cătălina , NIŢU Eduard Laurenţiu , GAVRILUŢĂ Ana Cornelia , VLAD Georgica Gheorghiţa , DOBRE Elena Mădălina , GHEORGHE Marian , STAN Maria Magdalena
Published: February 2024

The strong competition in the automotive industry has required manufacturers to implement lean production, both with methods and techniques specific to Industry 4.0. At the same time, universities must provide graduates with specific skills for applying these new production methods and techniques. In this context, a Lean Learning Factory was developed in the Pitesti University Center, which allows students to learn, experiment, and research, in an environment similar to that of enterprises, the new Lean Manufacturing methods and techniques, and Industry 4.0. The research presented in this study had as its objective identifying the minimum number of repetitions necessary to train operators who serve two differently organized workstations, one classic, the other including digital techniques, but on which the same assembly operation is performed. Several indicators were considered in the analysis, such as the number of errors, the number of stops, the effective duration of the work cycle, and the percentage ratio between the standard duration of cyclical activities and the effective duration of the work cycle. The evolution of these indicators was mathematically modelled by regression functions, using the least squares method. The obtained results also highlight the usefulness of applying the DOJO method as a Lean manufacturing-specific learning technique and the efficiency of implementing digital techniques in work organization.
Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity by Nuclear Medicine Diagnostic Imaging With 18F-Flurodeoxyglucose – Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dysfunction
Authors: Moncayo Roy , Moncayo Helga
Published: February 2024

Cardiotoxicity is an unwanted side-effect arising from different medications. The term describes a diminution of heart function, affecting especially left ventricular ejection fraction, which can progress to heart failure. Pediatric oncology patients treated with drugs of the anthracycline group, e.g., doxorubicin, can evolve to heart failure patients in adult age. Nuclear Medicine imaging of fatty acid oxidation and glycolysis accurately describes normal and altered heart metabolism. The most common finding is a state of cardiac glycolysis, which is reflected by increased uptake of 18F-desoxyglucose (18F-FDG) at a time when fatty acid oxidation is decreased. Glycolysis has recently been recognized as being the result of coenzyme Q10 deficiency as part of adaptation to hypoxia. Low LEVF correlates with impaired fatty acid oxidation. This deficiency can arise from chemotherapy and radiation and can be corrected by supplementation. Drugs like enalapril can improve fatty acid utilization. We will review relevant Nuclear Medicine imaging studies as well as fundamental biochemical data that demonstrate this pathogenetic path.
Uncertainty Constraint on Headphone Secondary Path Function for Designing Cascade Biquad Feedback Controller with Improved Noise Reduction Performance
Authors: Hua Yang , Peng Linhui
Published: February 2024

The uncertainty in the secondary path of an Active Noise Control (ANC) headphone affects the waterbed effect and stability of the feedback system. This study focuses on the uncertainty of the secondary path when real users wear headphones, and proposes a new uncertainty constraint based on the measured results of the secondary path transfer function under different wearing conditions of dummy head and limited subjects. This constraint and a cascaded second-order infinite impulse response filter with fixed coefficients are used to formulate a control strategic function, which is optimized by the Improved Grey Wolf Optimizer (IGWO) algorithm to obtain the optimal controller with better noise reduction performance. The proposed method and simulation model are validated based on the experimental test results. The results demonstrate that the safety factor and waterbed suppressing factor contained in the proposed uncertainty constraint ensures more stable noise reduction and effective suppression of the waterbed effect for new subjects without a priori data.
Sweetpotatoes: The Super Food of the Next Century? An Intensive Review on Their Potential as a Sustainable and Versatile Food Source for Future Generations
Authors: Islam Shahidul
Published: February 2024

This review article aims to delve into several aspects of sweetpotatoes and their leaves, including their nutritional composition, health benefits, culinary uses, and potential future implications as a superfood. It suggests an in-depth exploration of sweet potatoes' history, status, and prospects, highlighting their significance and potential economic value. Sweetpotatoes, often referred to as a powerhouse of nutrients, have gained popularity recently due to their remarkable nutritional composition and versatile culinary uses. This starchy root vegetable comes from the Convolvulaceae family and is consumed worldwide, playing a significant role in diverse cultures and cuisines. Besides their vibrant colors ranging from orange to purple, sweetpotatoes offer many health benefits, making them an essential addition to a well-balanced diet. Its extraordinary nutritional profile and numerous health benefits make it a superfood. Incorporating it into the diet can improve digestion, strengthen immunity, and reduce the risk of chronic diseases. With their versatility in the kitchen, there is no deficiency of charming and healthy recipes to explore. So, make room for sweet potatoes on your plate and unlock their vast potential to enhance your overall health and well-being. Overall, the future of sweetpotatoes looks bright as research and innovation aim to improve their nutritional value, adapt them to changing climate conditions, develop new varieties and products, and promote sustainable production practices. These developments can contribute to food security, economic growth, and healthier diets. Future research should focus on nutritional composition, health benefits, sustainable farming practices, cultivar development, and industrial applications to ensure sustainable and efficient production. By prioritizing research in these areas, we can enhance the utilization of sweet potatoes in various fields and secure their future for the next century.
Comparative Metabolomics of Ligulate and Tubular Flowers of Two Cultivars of Calendula officinalis L.
Authors: Ossipov Vladimir , Khazieva Firdaus M. , Baleev Dmitry Nikolayevich , Salminen Juha-Pekka , Sidelnikov Nikolay Ivanovich
Published: February 2024

The main aims of this study were (1) to identify and compare the major biologically active compounds in the metabolome of ligulate and tubular flowers of two C. officinalis cultivars, ‘Golden Sea’ (GS) and ‘Paradise Garden’ (PG), and (2) to investigate the effect of different proportions of ligulate and tubular flowers in the inflorescences on their metabolome. Ultra-performance liquid chromatography with photodiode array detection and a Q Exactive Orbitrap high-resolution mass spectrometer were used to analyse the flower metabolome. Analysis of the metabolomics data revealed that polar lipids showed the most significant differences between flowers. Tubular flowers of PG and GS cultivars contained higher levels of 31 and 34 out of 36 lipids, respectively. Furthermore, tubular flowers of both cultivars contained significantly higher levels of phenolamides and caffeoylquinic acids, but lower levels of triterpenoids. To compare the metabolite content of the two C. officinalis cultivars, we analysed the data for their inflorescences. The study showed that GS inflorescences contained significantly higher levels of phenolic compounds and lipids than PG inflorescences. This GS advantage was due to two factors: firstly, the higher content of these metabolites in tubular flowers and, secondly, the higher proportion of tubular flowers in GS inflorescences.
A Quick Look at the Present and Immediate Future of Type 1 DM
Authors: Diez Lopez IGNACIO , Maeso Mendez Sandra
Published: February 2024

This work is a review of the current situation of type 1a diabetes mellitus in childhood. With a quick read, the reader will discover the current and immediate future challenges.
Aptamer-Based Biosensors for Bacterial Detection
Authors: Léguillier Vincent , Heddi Brahim , Vidic Jasmina
Published: February 2024

The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and treatment of infections. Biosensors based on nucleic acid aptamers integrat-ed with optical, electrochemical, and mass-sensitive analytical techniques have garnered intense interest for their versatility, cost-efficiency, and ability to exhibit high affinity and specificity in binding bacterial bi-omarkers, toxins, and whole cells. This review emphasizes the development of aptamers, their structural op-timization, and their use in bacterial sensing applications. Moreover, we explore barriers and develop per-spectives in applying aptamer-based bacterial detection.
Epidemiology, Clinical Manifestations, and Management of Prolactinomas: A Comprehensive Study
Authors: Mavritsakis Nikolaos , Șușan Răzvan Mihai , Șușan Monica Maria , Groza Gogean Gina , Ursu Vasile Emil , Rusu Răzvan Gheorghe , Boariu Dan , Ionescu Elena , Muntean Raul Ioan , Man Cristina Maria
Published: February 2024

This research delves into the epidemiology, clinical manifestations, and management of hyperprolactinemia, particularly focusing on prolactin-secreting pituitary adenomas, or prolactinomas, in Dolj County, a region historically underrepresented in medical literature. Hyperprolactinemia, a prevalent endocrine disorder, arises from excessive prolactin secretion by the pituitary gland's lactotrope cells and presents a diverse clinical picture. The most significant etiological contributors identified are prolactinomas, accounting for approximately 39% of all secretory pituitary tumors.
In light of hyperprolactinemia's substantial morbidity and prevalence, this study underscores the necessity of comprehensive understanding of its regional epidemiology and clinical presentations. Our methodology incorporated collecting retrospective data across various medical facilities in Dolj, ensuing a meticulous analysis of clinical features, paraclinical investigation outcomes, and therapeutic responses among patients with prolactinomas. Emphasis was placed on discerning risk factors, demographic characteristics, and associated comorbidities to encapsulate the full spectrum of these tumors' impact within the community.
Preliminary results suggest a nuanced incidence rate of prolactinomas within Dolj, with specific demographic and clinical trends potentially distinct from those reported in wider literature. These findings stress the critical role of localized studies in enhancing screening, diagnostic, and therapeutic protocols. Ultimately, this investigation offers critical insights into the epidemiology and symptomatology of prolactinomas in Dolj, significantly augmenting existing literature and informing regional medical practices.
Delivery of Therapeutics Using Bacteriophage Vectors
Authors: Venkataraman Srividhya , Shahgolzari Mehdi , Yavari Afagh , Hefferon Kathleen
Published: February 2024

Bacteriophages are viruses obligately infecting bacteria. They constitute the most numerous categories of biological forms populating our biosphere and are highly diverse and capable of infecting almost all bacteria. Phages make use of their host cell molecular machinery to express their own genes as they lack the ability to independently reproduce themselves. The inimitable characteristics of bacteriophages have enabled them to become propitious tools in biotechnology and genetic engineering. Phages show no tropism for mammalian cells but however, can be easily modified to present targeting ligands on their surface as coat protein fusions without any negative impacts on phage structure. These displayed ligands thereupon guide the recognition, interaction, and internalization of the phage into cells wherein efficiency of transfection is directly influenced by the copy number of the ligands used for targeting. Engineered phages are more efficacious for transgene delivery and gene expression in cancer cells when compared to other non-viral gene transfer strategies and are therefore being employed in developing cancer vaccines. The high level of stability as well as resistance of bacteriophages to various environmental conditions have enabled the development of virus-like particles (VLPs) capable of successful deliverance of several therapeutic drug cargos into tumors by selective targeting. Phage display technology has been used in therapy of Alzheimer’s disease and drug delivery into the brain. Exogenous peptides fused into the coat protein of phages enables the display of these peptides on the phage surface to generate combinatorial phage that facilitates their rapid separation using their ability to bind to a specific molecular target. Phage therapy has been shown to be safe in clinical settings when compared to antibiotics as it shows no adverse anaphylaxis nor adverse effects such as the emergence of multi-drug resistant bacteria. This review provides intriguing details of the use of natural and engineered phages in the therapy of diseases such as cancer, bacterial infections, bovine mastitis and dementia in addition to the use of CRISPR-Cas9 technology in generating genetically engineered phages. Further, the use of phage display technology in generating monoclonal antibodies against various human diseases is elucidated.
UAV Photogrammetric Surveys for Trees’ Height Estimation
Authors: Vacca Giuseppina , Vecchi Enrica
Published: February 2024

In the context of precision agriculture (PA), geomatic surveys exploiting UAV platforms allow the trees’ dimensional characterization and crown identification. This paper focuses on the use of low-cost UAV photogrammetry to estimate the trees’ height, as part of a project for the phytoremediation of contaminated soils. Two study areas (Area 1; Area 2) have been chosen, having different characteristics in terms of mean trees’ height (5 m; 0.7 m), to test the procedure even in a challenging context. Three campaigns have been performed in Area 1 at different altitudes (30 m, 40 m, 50 m), and one UAV flight is available in Area 2 (42 m of altitude). The implemented workflow involves the elaboration of the UAV point clouds and DSMs using the standard SfM approach, the vegetation filtering, the generation of the DTM and a GIS-based analysis to obtain the CHMs for the extraction of the trees’ heights based on a local maxima approach. UAV-derived heights have been compared with in-field measurements obtaining promising results in Area 1, confirming the applicability of the procedure for trees’ height extraction, while the application in the context of low trees was more problematic.
Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid
Authors: Savuca Alexandra , Chelaru Alexandru Ionut , Balmus Ioana-Miruna , Curpăn Alexandrina-Ștefania , Nicoara Mircea Nicusor , Ciobica Alin
Published: February 2024

Microplastic pollution represents an emerging problem of great interest in the public domain in the last decade; in addition, it overlaps with another delicate problem - pollution with pharmaceutical products that can have negative effects on the environment and people, even in small amounts. The main purpose of this study was to assess the biochemical and behavioral effects of exposure of adult zebrafish (Danio rerio) to polyethylene (PE), polypropylene (PP) and valproic acid (VPA), respectively to their mixtures - possible situations in natural aquatic environments. In terms of behavioral responses, sociability appears to be more impaired in the PP group after 5 days of exposure. The mechanisms affected are more those of swimming performance than of sociability. Even more, VPA increases presence in the arm with conspecifics but decreases mobility and locomotion, indicating a possible anxiety mechanism. The mixtures decrease the aggressiveness, especially in the case of the PE+VPA group, where it reaches a super low level compared to the control, which could endanger the species in nature. Regarding the anxiogenic effect, PP and PE act differently, if PE has an anxiogenic effect, on the opposite side is the PP group, which shows a bolder and more agitated behavior. All four variants showed behavioral changes indicative of toxicity from the first dose.
Neutrophil Activation in Diabetes Mellitus (DM)? Role of PAD4 Expression in STZ-Induced Diabetic Rat
Authors: Kang Hsu Lin , Kupai Krisztina , Valkusz Zsuzsanna , Szasz Andras , Várkonyi Tamás , Csonka Ákos , Pósa Anikó , Matusovits Danica
Published: February 2024

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of generating citrullinated proteins which is one type of protein posttranslation modifications (PTMs). Additionally, peptidylarginine deiminases 4 (PAD4) is a component of neutrophil extracellular traps (NET) that leads to autoimmune disease during NETosis. Our aim was to check the PAD4 enzyme expression at level of gene and protein expression in streptozotocin (STZ) induced diabetic rat pancreas and checking the link between PAD4 and inflammatory cytokines. Wistar rats were divided into two groups: control group and diabetic STZ group. STZ was administered by intraperitoneally (60 mg/kg/ body weight). Rats were caged for six weeks and then terminated. Pancreatic tissue was harvested for measurement of PAD4 protein expression, PAD4 mRNA, citrulli-nated histone-3 protein (CITH3), cytokines and Ca2+ content. All measurements in diabetic rats were significantly in-creased compared to non-diabetic rats (p
Application of biofloc technology in the larval rearing of zebrafish (Danio rerio)
Authors: Martins Gabriel Bernardes , Oliveira Bernar , Ferrigolo Fernanda Rodrigues Goulart , Pretto Alexandra , Lanes Carlos Frederico Ceccon
Published: February 2024

The aim of this study was to investigate the different strategies of biofloc addition to zebrafish (Danio rerio) larviculture, and evaluate their growth and biochemical parameters. Three treatments were used: addition of 200 mL biofloc once at the start of the assay (O1), addition of 100 mL biofloc every seven days (1W), and addition of 100 mL biofloc every four days (2W). The 1W and 2W treatments also received 200 mL biofloc at the start of the assay. Regarding water quality, the only difference was the total suspended solid concentration, because the 2W treatment had a higher concentration in the final assay (127.6 ± 24.3 mg L-1). The final weight, survival rate, and juvenile percentile did not show statistical differences among the treatments. However, the O1 treatment exhibited a higher total length (11.93 ± 0.45 mm) than those in the 2W treatment. The juveniles in the 2W treatment exhibited lower nonprotein thiols and higher TBARS concentrations than those in the other treatments. Thus, the biofloc system can be a viable alternative to zebrafish larviculture without the use of conventional live food, and the addition of biofloc once (O1) at the beginning of larval rearing achieves good growth and survival results.
Correction of isthmic-cervical insufficiency using anchor ligatures with a titanium fixator. First experience
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. , Kazantsev A.A. ,   Central Clinical Hospital of the Russian Academy of Sciences, Moscow, Russian Federation, Borisova N.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zemlina N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Goncharenko N.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khokhlova I.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Aleksandrov L.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gorbenko O.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Azarova O.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chushkov Yu.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Budnikova K.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Asambaeva A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khalyavka E.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

This article presents a pilot study of surgical correction of isthmic-cervical insufficiency (ICI) in 5 patients aged 29 to 45 years with singleton pregnancies at gestational ages ranging from 13–14 to 19–20 weeks. An original method of cerclage using a spiral suture, anchor ligatures, and a titanium fixator was developed, the main purpose of which is to prevent cervical injury by the erupting suture of the terminal fixing block of the anchor ligature. This method of ICI correction is expected to contribute to optimization of the results of surgical treatment and improvement of perinatal outcomes. Key words: isthmic-cervical insufficiency, anchor ligatures, titanium fixator, cerclage, spiral suture
Analysis of the effectiveness of vitamin and mineral supplementation during pregnancy
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ozolinya L.A. , Kariy A.S. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Belikova A.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kuznetsov D.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: February 2024

Pregnancy increases the need for vitamins, which is almost impossible to compensate for by changing dietary intake. This need is increased by negative environmental impacts, several diseases of the gastrointestinal tract and liver, long-term illnesses, antimicrobial therapy, and other factors. Objective. To study the effect of vitamin and mineral complex (VMC) “Miteravel Plus” on overall well-being and sleep quality, skin, hair, and nail conditions, as well as gastrointestinal tract function in pregnant women and in women in the preconception period. Patients and methods. This prospective observational study included 1544 patients: 246 women preparing for pregnancy and 1298 pregnant women. All patients took “Miteravel Plus” one capsule once a day. The duration of VMC administration was left to the discretion of pregnant women and their attending physicians. Two questionnaires were carried out during the study: before and 1 month after the use of VMC. Results. Administration of VMC helped to decrease nausea and vomiting in the first trimester of pregnancy, increase physical activity, improve sleep quality and conditions of skin, hair, and nails (p < 0.05). Conclusion. Vitamin and mineral complex “Miteravel Plus” compensates for a greater demand for vitamins and micronutrients in the preconception period and during pregnancy, improving the overall well-being of women in early gestation. Key words: pregnancy, dyssomnia, nausea and vomiting of pregnancy, gastrointestinal function
Endometriosis. New therapeutic targets
Authors:   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Patsap O.I. ,   Federal Center of Brain Research and Neurotechnologies, Moscow, Russian Federation, Babkina A.V. ,   City Clinical Oncological Hospital No 1, Moscow, Russian Federation, Khabarova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Buyanova A.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Mikhalev S.A. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Atyakshin D.A. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation,   N.N.Burdenko Voronezh State Medical University, Voronezh, Russian Federation, Davydov A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Mikhaleva L.M. ,   A.P.Avtsyn Research Institute of Human Morphology; B.V.Petrovsky Russian Research Centre of Surgery, Moscow, Russian Federation, Ignatyuk M.A. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Volodkin A.V. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: February 2024

Endometriosis has been studied for more than 100 years, but to date, none of the proposed therapeutic strategies has provided a complete cure or avoided recurrence of the disease. This review considers current treatment options for endometriosis according to the pathogenetic principle, discusses the advantages and disadvantages of each of them. It remains difficult to define a window of opportunity for the treatment of endometriosis. There are currently no recognized treatment methods that prevent the development of this pathology; there is no evidence for the role of pharmacotherapy as an adjuvant to surgery, and it remains unclear how to treat disease recurrence. Therefore, new therapeutic targets in the treatment of this complex pathology are considered from the perspective of recent data on the pathogenesis of endometriosis. Key words: endometriosis, pathogenesis, endometriosis treatment, surgical treatment
Vulvar reconstruction after post-episiotomy infection
Authors:   City Mariinsky Hospital, Saint Petersburg, Russian Federation, Ivanov O.A. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Linde V.A. ,   City Mariinsky Hospital, Saint Petersburg, Russian Federation,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Palastin P.M. ,   City Mariinsky Hospital, Saint Petersburg, Russian Federation,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Khavanskiy A.Yu. ,   City Mariinsky Hospital, Saint Petersburg, Russian Federation, Boikova E.A. ,   City Mariinsky Hospital, Saint Petersburg, Russian Federation, Mitchenko G.V. ,   City Mariinsky Hospital, Saint Petersburg, Russian Federation, Mozgovaya A.O. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
Published: February 2024

This article presents a clinical case of suture purulent infection after lateral episiotomy in a postpartum patient with subsequent secondary intension healing. In 12 months after delivery, a reconstructive plastic surgery was performed to restore perineal integrity and, more importantly, to correct the aesthetic defect of the genital area. An original approach to mucosal flap excision and, accordingly, the use of non-standard access to anatomical structures was proposed. As a result, restoration of perineal anatomy and vulvar ring integrity was achieved. Key words: purulent infection, colporrhaphy, perineum, scar deformity, episiotomy
Crimen y castigo en Andalucía durante el siglo XV
Authors: Cabrera Emilio
Published: February 2024

Este estudio pretende dar una visión global de la criminalidad en la Andalucía del siglo XV estudiando, al mismo tiempo, algunas de las medidas utilizadas por las autoridades para evitarla y reprimirla. Contrariamente a lo que es posible descubrir en otros lugares, donde los documentos que contienen procesos judiciales y policiales han sido bien conservados, esta investigación se basa en el escrutinio de documentos que, si bien no son ideales, permiten la consideración de algunos de los problemas básicos inherentes al tema de la criminalidad.
Aportaciones al estudio de las murallas medievales de Córdoba. Estructura y técnicas de construcción en el sector Ronda del Marrubial
Authors: Córdoba de la Llave Ricardo , Marfil Ruiz Pedro
Published: February 2024

Basado en la intervención arqueológica llevada a cabo en 1994, durante el proceso de restauración del fragmento de muralla existente en la calle Ronda del Marrubial, el trabajo estudia el sector mejor conservado de las murallas orientales de Córdoba. Se examinan las características del amurallamamiento islámico de la Axerquía, datado en el siglo XII. De esa muralla islámica no se conservan restos en superficie, por lo que todos sus elementos han sido estudiados en labores de excavación. A continuación, se describen las reformas efectuadas en este sector del recinto amurallado durante el siglo XIV, tras la conquista cristiana de la ciudad. Finalmente, se aborda el examen de los rasgos principales de la muralla bajomedieval hoy conservada, materiales y técnicas de construcción, disposición de elementos defensivos y estructura del recinto fortificado.
Los regidores de Córdoba en 1480. Aproximación prosopográfica.
Authors: Cabrera Margarita
Published: February 2024

Uno de los grupos sociales más influyentes en la ciudad de Córdoba durante la segunda mitad del siglo XV fue el constituido por los regidores de la ciudad. Conocidos habitualmente con el nombre de veinticuatros, por haber sido ése el número teórico de sus componentes desde la segunda mitad del siglo XIV, su número ascendió de forma considerable a partir del siglo siguiente hasta el punto de superar el centenar.Este trabajo estudia la composición del mencionado grupo en el entorno de 1480, cuando las disposiciones de las Cortes de Toledo pusieron límite a ése y a otros abusos heredados de los reinados anteriores. Intenta fijar las distintas conexiones sociales, políticas y económicas de los regidores cordobeses y contiene un completo índice prosopográfico de los regidores cordobeses.
Caza y cazadores en la Castilla bajomedieval.
Authors: Del Pino García José Luis
Published: February 2024

La caza puede considerarse como uno de los ejercicios donde el instinto de agresividad y el espíritu lúdico se encuentran estrechamente ligados. El hombre la practica también para defenderse de una naturaleza hostil, asegurarse el alimento u obtener un beneficio en el mercado; suministradora de carne y de pieles, desempeña un papel innegable en las economías medievales. Aparece reflejada en la Literatura y en el Arte. En las clases superiores de la sociedad se ritualiza. Sus prácticas y sus técnicas son codificadas y enseñadas en libros que le consagran importantes personajes. La caza, en fin, da lugar también a una reglamentación y a un derecho que tienden a concebirla como un monopolio de los poderosos. Este trabajo pasa revista a esos y a otros problemas refiriéndolos al reino de Castilla durante la Baja Edad Media.
Apuntes sobre un excepcional mosaico de influencia bizantina en el antiguo convento de Santa Clara.
Authors: Penco Velenzuela Fernando
Published: February 2024

Secuencia estratigráfica arqueológica, componente constructivo, elemento compositivo y estilístico, iconografía y paralelos son los aspectos en los que intentaremos adentrarnos en este estudio que ofrecemos bajo las siguientes líneas. Se trata de un primer avance de carácter preliminar que pretende extraer una valoración acerca de una excepcional pieza musiva de tradición bizantina que, sin duda, contribuirá a suscitar de nuevo el replanteamiento de uno de los períodos históricos más discutidos, con menos testimonios en el registro arqueológico de nuestro pasado y que, estimamos, sirva de ayuda a la búsqueda del origen y utilidad de la pieza y su entorno arquitectónico.
Identificación del material óseo de la Casa de Yafar y de las viviendas de servicio de Madinat az-Zahra.
Authors: Agüera E. , Vivo J. , Monterde J. G. , Mir F. , Robina A. , Galisteo A. M. , Cabrera Emilio , Córdoba de la Llave Ricardo
Published: February 2024

El presente trabajo estudia los restos óseos hallados durante la limpieza de las canalizaciones de dos sectores del palacio califal de Madinat az-Zahra, la Casa de Yafar y las viviendas de servicio. Se analizan los huesos pertenecientes a pequeños rumiantes (oveja, cabra), que son los más abundantes, así como a diversos tipos de aves (en especial, gallina) y otras especies consumidas por los habitantes del palacio califal durante el siglo X.
Ordenación y control de la vida económica en Plasencia: el abasto de la carne.
Authors: Lora Serrano Gloria
Published: February 2024

El suministro de productos alimenticios básicos a la población de Plasencia, así como el control de su venta y consumo fue una de las principales preocupaciones de las autoridades municipales. El abasto de la carne, que estaba estrictamente controlado por las ordenanzas municipales, estuvo encomendado por el concejo a los «obligados», individuos que estaban comprometidos a proveer suficientemente las tablas de las carnicerías, llamadas togas. Este acuerdo se establecía mediante contrato concedido a quien ofrecía la carne al precio más bajo mediante subasta pública. Al final de la Edad Media, todos los «obligados» eran personas de Plasencia que pertenecían a las oligarquías locales; esto causó importantes abusos en el suministro, porque las autoridades buscaban su propio beneficio en lugar de los precios más bajo en el abasto. La venta de la carne se hacía en las carnicerías públicas cuya existencia nos consta al menos desde 1338. Desde el siglo XIII se diferenciaron las carnicerías cristianas de la específica para los judíos, ubicada probablemente en la plaza mayor. Aparte existía la llamada toga de abades, propiedad del cabildo catedral; su existencia fue fuente de con¬tinuos conflictos con el poder municipal. El consumo de carne rojas fue predominante. Los menudos, de alto valor nutritivo y bajo precio, eran alimento propio de los vecinos de clases más modestas, igual que la carne de los cerdos, criados junto a pollos, gallinas y patos. Perdices, conejos, palomas y liebres completaban la oferta de carnes; eran ofrecidos por los mismos cazadores en unos portales localizados junto a las carnicerías.
Un texto pediátrico del siglo XIV: el Tratado de los Niños de Bernardo de Gordonio.
Authors: Cabrera Margarita
Published: February 2024

Entre los tratados médicos que salieron a la luz durante la Edad Media, destacan aquellos que centraron su atención en la vida de los niños. La información contenida en esos textos pediátricos resulta imprescindible para conocer cuáles eran las enfermedades que afectaban a los más pequeños, así como algunos aspectos referidos a la vida infantil durante la Edad Media, como la alimentación, la higiene o la indumentaria. Entre esos tratados de pediatría resulta especialmente interesante el Tratado de los niños, que fue realizado en el siglo XIV por Bernardo de Gordonio, y que hemos sacado a la luz en el presente trabajo.
Entre la violencia y la marginación: el establecimiento en Burgos de futuros mercaderes.
Authors: Caunedo del Potro Betsabé
Published: February 2024

El objeto de este trabajo es acercamos al origen y a un primer establecimiento en Burgos de algunos mercaderes que a finales del siglo XV se convertirían en profesionales de éxito. Además de la fascinación por la gran ciudad y de la posibilidad de encontrar en ella nuevas formas de vida, concurren en las mismas circunstancias turbias, acontecimientos sospechosos y o ilícitos que acaso fuese mejor olvidar.
Confituras y conservas en los recetarios técnicos (siglos XV-XVII)
Authors: Criado Vega Teresa María
Published: February 2024

Resumen:

Hasta hace unos años las mujeres en las épocas del año con abundancia de productos se dedicaban a realizar conserva de alimentos, usando para ellos diversos procedimientos. Algunas de dichas técnicas nos llevan a épocas pasadas y se encuentran recogidas en recetas, varias de las cuales nos han llegado y son objeto del presente trabajo.

Abstract: Until a few years ago, women with abundant products during the year devoted themselves to preserving food, using various procedures for them. Some of these techniques take us to past times and are included in recipes, some of which have come to us and this time they are the object of this work.
«Es comida de villano». Aspectos sociales de la alimentación en el tratado renacentista De todas las cosas que se comen de Michele Savonarola
Authors: Pasalodos Requejo Sergio
Published: February 2024

El médico italiano renacentista Michele Savonarola, en su tratado dietético De todas las cosas que se comen, repasa los diferentes alimentos presentes en la dieta de la época y sus características, con interesantes comentarios sobre aspectos sociales relacionados con ellos. Analizando estas observaciones podemos ver que lo que se come y cómo se come viene determinado por su posición social, ya que, para la ciencia médica de la época, la dieta se relaciona directamente con la cantidad de ejercicio físico realizado, lo que está ligado a la actividad profesional y por tanto a la clase social.
Plan de negocio, ventas de repuestos de camiones europeos en Lima metropolitana
Authors:   , Huillca Flores Elizabeth Milagros , Guadalupe Estrella Juan Carlos
Published: February 2024

En estos últimos años pasados la coyuntura sanitaria a nivel mundial, observamos los declives por parte de los transportistas a la hora de comprar repuestos para sus camiones, cuando se les presenta sus mantenimientos correctivos o preventivos ya sean programados o imprevistos a la hora de reponer repuestos malogrados por uno nuevo y de alta calidad. Las falencias son notorias cuando se tienen que ir a buscar los repuestos de cambio presencialmente en las tiendas minoristas, por las zonas de gran acogida de ventas de repuestos, donde generalmente se tienen que tomar horas de viaje y búsquedas, en donde lo incierto de encontrar el repuesto requerido es de gran probabilidad. Es por ello que nuestro presente plan de negocio de venta de repuesto para camiones europeos está enfocado en solucionar estos declives, mencionado en líneas anteriores. Nuestra propuesta es emplear la estrategia de ventas vía online, donde nuestros vendedores tendrán una comunicación directa con los clientes, vía online (WhatsApp, Messenger, llamadas telefónica, etc.) atendiéndolos de una forma más directa, para así realizar la cotización y envío del repuesto en una forma más óptimo, en un menor tiempo. Es así como para nuestro plan de negocio realizamos la ejecución de múltiples análisis estratégicos como financieros, para poder ver la viabilidad y rentabilidad de dicho negocio, teniendo las consideraciones de la demanda y público objetivo donde se realizará las ventas de repuestos online. Por lo tanto, decimos que nuestro plan de negocio si es viable y si se lograra alcanzar al público objetivo con sus demandas requeridas en los tiempos establecidos.
Protocol of a systematic review and meta-analysis of risky sexual behaviors among adolescents and young adults in West Africa
Authors: N’DRI Kouamé Mathias , KONAN Yao Eugène , Saka Bayaki , MELESS Djedjro Franck Renaud , NAMBIEMA Aboubakari , YAYA Issifou
Published: February 2024

Background
Sexually transmitted infections (STIs) are a major public health concern, particularly among adolescents and young adults living in West Africa who reported higher prevalence of risky sexual behaviors. We therefore proposed a protocol for systematic review and meta-analysis to assess the prevalence of risky sexual behaviors for STIs among adolescents and young adults living in West Africa.
Methods and analysis:
Systematic searches of electronic databases (PubMed/MEDLINE, Embase, African Index Medicus) will be conducted. Studies published between January 1st, 2013 and June 30th, 2023 on the prevalence of sexual behavior at risk of STIs in adolescents and young adults living in West Africa will be included. Two reviewers will independently conduct studies selection, data extraction and risk of bias assessment. The selection of eligible studies will be based on titles and abstracts and then on full text. The risk of bias assessment of eligible studies will be performed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). If possible, a meta-analysis of data on the prevalence of each sexual risk behavior will be performed. The heterogeneity will be statistically assessed using a I2 statistic. This protocol is developed following the guideline of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols 2015. STATA or R software will be used for the meta-analysis.
Discussion
This review will estimate the prevalence of risky sexual behaviors for STIs among adolescents and young adults aged 15–24 years in West Africa in order to propose appropriate interventions.
Carbon dioxide removal deployment consistent with global climate objectives
Authors: Ganti Gaurav , Gasser Thomas , Bui Mai , Geden Oliver , Lamb William , Minx Jan , Schleussner Carl-Friedrich , Gidden Matthew
Published: February 2024

The IPCC 6th Assessment Report lacked sufficient land sector scenario information to estimate total carbon dioxide removal (CDR) deployment. Using a new dataset, we show that land CDR plays an important near-term role and novel removal technologies scale to multi-gigatonne levels by 2050 and beyond to balance residual emissions and draw down warming. Reducing fossil fuel and deforestation emissions accounts for over 80% of net greenhouse gas reductions until global net zero CO2 independent of climate objective stringency.