bluuebunny/crossref_metadata_2025 huggingface dataset:
BBX7 interacts with BBX8 to accelerate flowering in chrysanthemum
Authors: Zhai Yiwen , Zhu Yuqing , Wang Qi , Wang Guohui , Yu Yao , Wang Lijun , Liu Tao , Liu Shenhui , Hu Qian , Chen Sumei , Chen Fadi , Jiang Jiafu
Published: April 2023

The quantitative control of FLOWERING LOCUS T (FT) activation is important for the floral transition in flowering plants. However, the flowering regulation mechanisms in the day-neutral, summer-flowering chrysanthemum plant remain unclear. In this study, the chrysanthemum BBX7 homolog CmBBX7 was isolated and its flowering function was identified. The expression of CmBBX7 showed a diurnal rhythm and CmBBX7 exhibited higher expression levels than CmBBX8. Overexpression of CmBBX7 in transgenic chrysanthemum accelerated flowering, whereas lines transfected with a chimeric repressor (pSRDX-CmBBX7) exhibited delayed flowering. Yeast single hybridization, luciferase, electrophoretic mobility shift, and chromatin immunoprecipitation assays showed that CmBBX7 directly targets CmFTL1. In addition, we found that CmBBX7 and CmBBX8 interact to positively regulate the expression of CmFTL1 through binding to its promoter. Collectively, these results highlight CmBBX7 as a key cooperator in the BBX8–FT module to control chrysanthemum flowering.

Graphical Abstract
Recenzja książki Charków – Katyń – Twer – Bykownia
Authors: Gawrońska Ewa
Published: April 2023

Recenzja książki Charków – Katyń – Twer – Bykownia
Recenzja książki Kobiety Niepodległej
Authors: Gawrońska Ewa
Published: April 2023

Recenzja książki Kobiety Niepodległej Michała Laszczkowskiego
Sylwia Chutnik, Opowieści na dobranoc dla młodych buntowniczek. 100 historii niezwykłych Polek, Wydawnictwo Debit, Katowice 2021, ss. 208
Authors: Kromp Dorota
Published: April 2023

Recenzja książki "Opowieści na dobranoc dla młodych buntowniczek. 100 historii niezwykłych Polek" Sylwii Chutnik.
Dokument czechosłowackiego wywiadu wojskowego o współpracy z Oddziałem II Sztabu Głównego Wojska Polskiego z 1934 roku
Authors: Kołakowski Piotr
Published: April 2023

W okresie międzywojennym dobrze rozwijała się polsko-czechosłowacka współpraca wywiadowcza. Dotyczyła ona przede wszystkim rozpoznania potencjału militarnego Niemiec. Współpraca wywiadów obu państw polegała głównie na organizowaniu wspólnych konferencji ewidencyjno-wywiadowczych. Została przerwana z powodów politycznych wynikających z odmiennych koncepcji zapewnienia sobie bezpieczeństwa przez Warszawę i Pragę oraz braku porozumienia pomiędzy Polską i Czechosłowacją.
Open questions about the farmlands’ biodiversity preservation in the cities’ peripheries – a Wrocław case (Poland)
Authors: Fudali Ewa , Podlaska Magda , Koszelnik-Leszek Anna , Szymanowski Mariusz
Published: April 2023

One of the necessary conditions for sustainable development is maintaining and developing environmental resources. The paper presents and discusses the idea that the field woods in the cities’ agricultural periphery, understood as habitats and not only a collection of trees, should be preserved and managed as a formal element of urban green infrastructure (GI). According to the authors, they should be seen as a great connecting element between urban green and the semi-natural areas outside. Even assuming the future land use transformation, it is worth preserving them from degradation just now. They play a role in protecting natural resources and the functions of ecosystems, expected from elements of GI, as they are a source of dispersion of various species of plants and animals benefit both for agricultural areas located further and for greenery in built-up areas. Using the authors’ own research on the farmland area situated within Wrocław administrative borders, and available literature, the following issues were considered: 1) the geographic and topographic characteristics of field woods, 2) evaluation of the role of field woods studied for the local biodiversity, 3) the risk factors for the degradation or disappearance of field woods and their biodiversity, 4) the legal regulations concerning the protection of field woods in Poland. Some legal and practical solutions are suggested.
Laboratorium pierestrojki? Generał Jaruzelski na geopolitycznej szachownicy
Authors: Kozłowski Tomasz
Published: April 2023

Artykuł składa się z dwóch części. W pierwszej z nich opisana jest geneza oraz wdrożenie nowej polityki Związku Radzieckiego względem krajów socjalistycznych Europy Środkowo-Wschodniej. Jej głównym założeniem było poszerzenie marginesu swobody politycznej przy jednoczesnym ograniczeniu wsparcia finansowego. W drugiej części opisana jest implementacja tej strategii na przykładzie Polskiej Rzeczypospolitej Ludowej od połowy lat osiemdziesiątych aż do momentu transformacji.
Integracja imigrantów ze społeczeństwem przyjmującym. Na przykładzie uczestnictwa w tradycjach, świętach, uroczystościach i życiu kulturalnym
Authors: Sowa-Behtane Ewa Agata
Published: April 2023

Niniejszy artykuł przedstawia problem integracji imigrantów w Polsce, który próbowano zbadać za pomocą przeprowadzonych w 2022 roku metodą sondażu diagnostycznego badań, w których wzięło udział 56 imigrantów mieszkających w Krakowie. Aby osiągnąć zamierzony cel badawczy, zapytano badanych m.in. o opinie na temat uczestnictwa w polskich świętach i tradycjach, zapoznawania swoich polskich znajomych ze zwyczajami i tradycjami charakterystycznymi dla swojej kultury, uczestnictwa w polskim życiu kulturalnym (polskie kino, polski teatr, polskie wystawy, koncerty polskich artystów). Z analizy badanych wskaźników wynika, że zdecydowana większość badanych (ok. 70–80%) w wysokim stopniu integruje się ze społeczeństwem przyjmującym. Zdecydowana większość badanych (blisko 90%) twierdziła, że polskich znajomych zapoznaje ze swoją kulturą narodową. 65% badanych twierdziło, że bardzo często bądź często uczestniczy w polskim życiu kulturalnym. Wciąż jednak należy dbać o tę grupę imigrantów, która ma problemy z integracją. Istnieje potrzeba modyfikowania polityki integracji, a także wprowadzania w szerszym zakresie edukacji międzykulturowej do szkół oraz na uczelnie wyższe.
Wyzwania moralne Globalnego Paktu Wychowawczego w nauczaniu papieża Franciszka
Authors: Kućko Wojciech
Published: April 2023

Głównym celem artykułu jest analiza koncepcji Globalnego Paktu Wychowawczego oraz propozycji wcielenia jej w praktykę na bazie nauczania papieża Franciszka. Idea nowego „przymierza wychowawczego” jest adekwatną i integralną próbą odpowiedzi na obecne wyzwania w kontekście dokonującej się zmiany epoki i poszukiwań nowego humanizmu. Koncepcja ta nie została jeszcze opracowana w szerszy sposób w języku polskim, dlatego w artykule prezentowane są jej główne założenia oraz implikacje etyczne. Omówionych jest siedem płaszczyzn realizacji paktu wychowawczego oraz wynikające z nich wyzwania moralne: docenienie misji szkoły, odkrycie na nowo tożsamości szkół katolickich, ukazanie nowej roli uniwersytetów oraz wartości piękna w procesie formacji ludzkiej.
The Effect of Education, Health, Minimum Wage, Foreign Investment on Labor Productivity in 33 Provinces of Indonesia
Authors: Maharani Nia Rizky , Woyanti Nenik
Published: April 2023

The competitiveness of labor is a key factor to encourage the competitiveness of a country's economy. Indonesia has low labor competitiveness due to uncompetitive labor productivity. In addition, Indonesia has a trend of declining labor productivity growth, so more serious attention is needed to make labor productivity better. This study aims to analyze the effect of education, health, minimum wage, and foreign investment on labor productivity using panel data from 33 provinces of Indonesia in 2010-2019. This research used a multiple linear regression FEM with cross-section weight and coefficient covariance method cross-section SUR (PSCE). The result proved partially, health and minimum wage have a significant positive effect, while education and foreign investment have an insignificant positive effect on labor productivity. The most dominant independent variable is health. Simultaneously, the four independent variables have a significant effect on labor productivity in 33 provinces of Indonesia
The Effects of Digitalization and GDP Per-Capita Growth on Tax Revenue in ASEAN Countries
Authors: Fajrina Annisa Sekar Irsa , Setiawan Benny
Published: April 2023

ASEAN’s digital economy is soaring up every year and bring potential additional tax revenue. In many countries, tax revenues dominate total state revenue but six out of ten ASEAN member countries couldn’t optimize its tax revenue hence  causing a social inequality and poverty This study aims to analyze the effects of digitalization indicated in internet penetration level and Gross Domestic Product per capita growth on tax revenue in ASEAN countries. Samples consists of 6 countries in ASEAN: Indonesia, Malaysia, Singapore, Cambodia, Phillipines, and Thailand; with dataset of 15 years observation from 2005 to 2019. By using data panel multiple regression analysis in Fixed Effect Model, the results indicate that: (1)digitalization has significant and positive influence on tax revenue, (2) GDP per capita growth has significant and negative influence on tax revenue, and (3) simultaneously digitalization and GDP per capita growth have significant influence on tax revenue.
Formulation for the Regulation of The Notary's Function and Role in Electronic General Meetings (GMS) of Shareholders
Authors: Koesnadi Merry
Published: April 2023

Legal politics in the era of technological development, makes the legal profession, especially notaries, must keep up with the times. A notary in carrying out his position as a Notary utilizes technology to facilitate the implementation of that position. Notaries as public/state officials have the authority to make authentic deeds. Notaries in carrying out their profession are required to adapt and keep up with the times, the goal is to be able to face the challenges of global competition. As time goes by, of course Science and Technology continues to develop, so that there are facilities such as internet networks and electronic media that can be used for two-way communication and make it possible to see each other such as chat, teleconference, and video conference. GMS (General Meeting of Shareholders) can also be held via teleconference, considering cost and time efficiency. Law of the Republic of Indonesia Number 40 of 2007 concerning Limited Liability Companies regulates things that can be done through teleconference media regulated in Article 77 Paragraph (1) of the PT Law so that it allows shareholders to hold GMS without having to meet in person and be in one place but can carried out by teleconference which allows shareholders to see each other and actively interact in meetings. The method used in this research is normative legal research which is carried out as an effort to obtain the necessary data related to the problem. The data used is secondary data consisting of primary legal materials, secondary legal materials, and tertiary legal materials. In addition, primary data is also used to support secondary data legal materials. Data analysis was carried out using qualitative juridical analysis methods. From the results of the research it can be obtained that the GMS held by teleconference is invalid because it violates the provisions in Article 16 paragraph (1) letter m UUJN which requires the physical presence of the parties in the process of preparing an authentic deed so that the strength of proof of the deed is under the hands as a result of an act which is not in accordance with Article 16 Paragraph (1) letter m. Notaries in this case have roles and functions related to cyber notaries. The deed of the GMS was made with a Cyber notary and the signing is permissible and legally done because in article 77 of the Company Law it is very clear that it is regulated then, in particular the signature gets legal protection provided by the ITE Law but the Cyber notary has not been fully supported by legislation in Indonesia , even though there is a possibility, it cannot be carried out because it is limited by other laws, so cyber notaries cannot be implemented legally in Indonesia. There is still a need for specific arrangements regarding cyber notaries in Indonesia.
An Analysis of Diversity of the GS-14, GS-15, and SES Ranks in the Department of Veterans Affairs from 2002-2022
Authors: Malone Duvalier
Published: April 2023

This article examines the diverse types of diversity, including age, disability, and sex/gender diversities, among the top three levels of management at the Department of Veterans Affairs. This research will shed light on these differences and their implications. By examining the differences among the top three levels of the senior leadership branch of government at the Department of Veterans Affairs (VA), this research seeks better to understand the impact of changes in diversity policies. As the Department of Veteran Affairs continues to transform, it is increasingly vital that we have the tools necessary to measure the impact of our efforts on our changing culture. From a diversity point of view, it will help us understand veterans as a social group and their inclusion in the workplace. In contrast, the person-environment fit perspective helps us describe veterans’ compatibility with their work environments in terms of organizational demands and veterans’ needs. National attention and resources are being brought to the issue of supporting the economic success of Veteran’s Affairs.
“Feeling Invisible”: Individuals With Borderline Personality Disorder Underestimate the Transparency of Their Emotions
Authors: Meulemeester Celine De , Lowyck Benedicte , Boets Bart , van der Donck Stephanie , Verhaest Yannic , Luyten Patrick
Published: April 2023

The present study investigated transparency estimation, that is, the ability to estimate how observable one's emotions are, in patients diagnosed with borderline personality disorder (BPD) (n = 35) and healthy controls (HCs; n = 35). Participants watched emotionally evocative video clips and estimated the transparency of their own emotional experience while watching the clip. Facial expression coding software (FaceReader) quantified their objective transparency. BPD patients felt significantly less transparent than HCs, but there were no differences in objective transparency. BPD patients tended to underestimate the transparency of their emotions compared to HCs, who in turn overestimated their transparency. This suggests that BPD patients expect that others will not know how they feel, irrespective of how observable their emotions actually are. We link these findings to low emotional awareness and a history of emotional invalidation in BPD, and we discuss their impact on BPD patients’ social functioning.
Lukács’ Red Revolution
Authors: Leslie Esther
Published: April 2023

Moving between autobiographical and biographical reflections on Lukács and the embeddedness of lives, his and briefly mine, in historical time, the persistent influence of his readings of culture and questions of form, science and a philosophy of praxis is to be reflected on. There is, in some quarters, a dominant Lukácsian reading of modernism, which he apparently dismisses as fragmentary and debilitating. However, there is much to be said about the ways his writings, especially the ones from the 1920s, leave traces and recurrently propel inquiry lines in less discussed areas: namely, thermal analyses of alienation and reification as picked up in Frankfurt School and Situationist thinking; synthetic color production, and communist self-activity. To observe this persistent generativity in the name of self-organization and dialectics is to value something under attack in the revival of anti-Semitism and anti-Communism in Hungary today.
Integration of remote sensing and geophysical data to enhance lithological mapping utilizing the Random Forest classifier: a case study from Komopa, Papua Province, Indonesia
Authors: Nugroho Hary , Wikantika Ketut , Bijaksana Satria , Saepuloh Asep
Published: April 2023

Lithological information is important in mineral resource exploration, geological observations, mine planning or degradation vulnerability assessment. Currently, lithology mapping can be performed in a fast, inexpensive, and easy way using remote sensing data and machine learning. Remote sensing techniques have become a valuable and promising tool for mapping lithological units and searching for minerals. Typically, the integration of remote sensing data with geophysical data provides a better diagnosis to lithological units than single-source mapping methodologies. Accordingly, this study used a combination of remote sensing and airborne geophysical data utilizing the Random Forest algorithm with small training samples to enhance lithology mapping in Komopa, Papua Province, Indonesia. Geophysical data consisting of magnetic, electromagnetic, and radiometric were added one by one gradually to the remote sensing data, which includes Sentinel 2A, ALOS PALSAR, and DEM (digital elevation model) to compare the accuracy of the classification results from each dataset. The results showed that the model that combined remote sensing data and the three types of geophysical data produced the best classification, with an overall accuracy of 0.81, precision of 0.66, recall of 0.47, and F1 score of 0.52. This fused data can increase the accuracy of the classification results by 8% overall accuracy, 6% precision, 11% recall, and 13% F1 score when compared to the model that only used remote sensing data.
Characteristics, stability, and utilization of sulfuric natural water from Sebau East Lombok in reducing dissolved metals
Authors: Hadi Surya , Rifandi Teguh , Abdillah Bakti , Qharomi Mozaik Al , Mahendra Lalu Riza , Hidayat L M Riza Rahman , Asnawati Dina , Murniati Murniati
Published: April 2023

This paper aims to characterize and test the stability of sulfuric natural water (SNW) from Sebau East Lombok as a sulfidation agent for several dissolved metals (Mn, Cu, Pb and Fe). The parameters used for SNW characterization are temperature, pH, DO, BOD, COD, TSS, and TDS. The sample was divided into two categories, namely the sample with preservation treatment and the sample without preservation, to study the stability of SNW. The SNW stability was determined by observing the SNW parameters in both samples at a storage time of 5, 10, 15 and 20 days and reacting them with dissolved metals. The SNW with preservation had reduced sulphide levels from day 1 to day 20, ranging from 59.24 mg/L to 17.70 mg/L, whereas the sample without preservation had decreased sulphide concentration from 52.46 mg/L to 9.56 mg/L. Furthermore, the SNW with preservation has a relatively superior metal reduction ratio than the sample without preservation. The maximum value of the deposition ratio for Mn metal was obtained on the fifth day with 57.60%, 83.45% for Cu, and 91.87% for Pb. This trend is not applicable for Fe, whereas the highest reduction (87.23%) was obtained on the the15th day's storage.
A case study of benign nodular episcleritis and management
Authors: Shah Rubina
Published: April 2023

Episcleritis is an inflammatory condition that affects episcleral tissue underlying the sclera and conjunctiva.1,2 It is a recurrent and mild self-remitting surface disease. Its etiology is unknown but may be associated with systemic diseases.3–5 It has been recognized for over a century as sub-conjunctivitis or subconjuctivitis phlegmatous. The condition is unilateral in two thirds of cases and bilateral in one third. Two major clinical types are noticed diffuse and nodular. The case outlined Nodular episcleritis and its clinical diagnosis and management. The condition was mild and didn’t progress to a more severe disorder. An episcleral nodule adjacent to the cornea is very rare.
Proposal on the combination of therapeutic alternatives for the treatment of pain in Primary Health Care
Authors: González José Julio Ojeda , León Miriam Iglesias , Cortes Manuel Cortes
Published: April 2023

The fight against pain is a concern of medicine since the emergence and development of the human being, as evidenced by several researchers. The scientific literature currently shows that a correct biopsychosocial assessment, an adequate and individualized comprehensive therapeutic plan and multidisciplinary management improve chronic pain in terms of pain reduction, essentially in terms of emotional, psychological and functional aspects. Adequate pain management is based on a correct performance of the medical staff, which leads to an improvement in the diagnosis and treatment of pain in Primary Health Care. Objective: The objective is to elaborate a proposal on the combination of therapeutic alternatives for the treatment of pain in Primary Health Care. Methods: Theoretical level methods such as synthetic analytical, empirical level observation and expert criteria were applied, with the Delphi method, and at the mathematical level, the relevant statistical analysis of the methods used. These allowed to propose the integration of Pharmacological, Psychological, Physical Medicine and Rehabilitation and Natural and Traditional Medicine contents for the integral treatment of pain in Primary Health Care. The proposal was scientifically assessed by experts through the Delphi method and was applied in two community health areas in the municipality of Cienfuegos, Cuba. Results: It is evidenced in the elaboration of the proposal to treat pain integrally, through the combination of pharmacological, non-pharmacological, Psychological, Natural and Traditional Medicine, Physical Medicine and Rehabilitation therapeutic alternatives, validated by the Delphi method, it was demonstrated the acceptance of very adequate the proposal by the selected specialists as well as the observation of the change of performance in the General Physician in Primary Health Care in the treatment of pain in the patients of the community. Conclusions: The proposal was validated as very adequate by the experts and its application in the context of Primary Health Care. Demonstrating the relevance of the proposal, we consider that the combination of therapeutic alternatives is a developing field that should be part of the professional skills of the General Practitioner.
High throughput in vitro production of somatic embryoswith innovative cryo cell banking system
Authors: Wang Weiming , Sanders La Shaun , Perry Alice , Duncan Ebonee
Published: April 2023

ArborGen Inc. was originally created as a partnership for forestry research in 2000 by West Rock (MWV), International Paper and Rubicon (Fletcher Challenge). It now produces the largest number of both conventional and advanced genetic tree seedlings in the world. Among its advanced genetics offerings, varietals have the highest level of genetic traits in yield and timber quality such as height, diameter growth, disease resistance and etc. To scale up varietals, in vitro process named somatic embryogenesis (SE) is used as a mean to mass propagate SE seedlings. Over the years of R&D efforts, we recognized that a key challenge for scale-up is the lack of a stable and predictable bioprocess platform. The primary causes that impact stability and predictability include a challenge to receive consistent supplies of good starting cell materials, the risk of somaclonal variation due to long term exposure tomaintenance media containing hormones and risk of contamination or loss from environmental fluctuations. Accordingly our SE R&D program has been targeted to develop a robust bioprocess platform to reduce these variabilities. One of our major achievement is the development of a cell banking (CB) system, which provides high quality starting cell materials for SE production. The cell banking system includes the creations of research cell banks (RCB) and master cell banks (MCB). After the cell banks are created, the banked cells are tested and validated for their qualification for embryo production. Currently, we successfully integrated the cell banking technology into somatic embryo production in a number of economically important tree species and crops, such as pine, spruce, sweetgum, sugarcane, avocado and banana. With the SE&CB platform, the somatic embryo & somatic seedling yields are consistent, predictable and are produced cost-efficiently on a commercial scale.
Knowledge and attitudes towards the management of chronic pain among healthcare providers in outpatient departments at the University Teaching Hospital of Butare (CHUB)
Authors: Gaston Nyirigira , Jean de Dieu Mahoro , Elias Rwamugema , M. Alex Buteera , Eugene Tuyishime
Published: April 2023

Introduction: Chronic pain is a major source of suffering and is a leading reason for many patients to consult health care personnel. It interferes with, and disrupts, activities of daily living and may be accompanied by distress. Irrespective of its etiology or classification, health care professionals require a good understanding of chronic pain in order to provide appropriate treatment and care. Methods: A cross-sectional study was conducted involving a sample of 80 participants obtained by using a convenience sampling method. Data were obtained by completing a questionnaire entitled “Knowledge and attitude survey towards pain” and analyzed by using descriptive statistics, chi-square, Pearson correlation coefficient and cross tabulation using SPSS. Results: Overall knowledge was inadequate. More than two thirds of participants obtained a score below 50%. There was also negative attitude, almost 51% of the participants have negative attitude to pain management. Higher level of knowledge was associated with medical profession, highest of qualification and training on pain management. Conclusion: The knowledge and attitudes of this sample of health care professionals regarding the management of chronic pain was inadequate to provide appropriate quality care for patients presenting with chronic pain conditions. This study identified the need for appropriate training for all health care professionals in order to assure adequate knowledge and skills to manage chronic pain using a multidisciplinary approach.
Environmental and maternal anthropometric determinants for low birth weight in maternity hospitals in Asmara, Eritrea
Authors: Andemariam Zeccarias , Teages Elias , Zerezghi Habteselassie , Seyoum Yemane
Published: April 2023

Background: Birth weight of a neonate is a vital indicator of the newborn’s chances for survival, growth, health and psychosocial development. This study was conducted to assess the environmental and maternal anthropometric factors that determine low birth weight (LBW) of a neonate. Methods: A cross-sectional analytical study was employed using questionnaires and anthropometric measurements on 806 mother-neonate pairs. Results: Statistically significant association was observed between maternal anthropometric factors and environmental factors with LBW. Conclusion: This study identified various environmental and maternal anthropometric risk factors. It is therefore recommended that multifaceted and coordinated measures to address these issues are required to reduce LBW to its lowest possible level.
Knowledge, Attitudes and Practices Related to Oral Health in Participants of the Institutional Program for the Inclusion of People with Cognitive Disabilities in Higher Education at the University of Costa Rica
Authors: Garita-Herrera Andrea , Torres-Montoya Jeimy , Alvarado-Prado Rebeca
Published: April 2023

People with cognitive disabilities face multiple challenges concerning oral health and frequently show oral tissue decay because of the barriers society imposes upon them, and due to financial issues, professional and family lack of knowledge, limitations regarding access to services, lack of empowering-driven actions, among others. Positive knowledge, attitudes and practices regarding oral health, developed during the course of a lifetime, help in preserving good health. The aim of the current study is to describe oral health knowledge, attitudes and practices in people with cognitive disabilities participating in the Institutional Program for the Inclusion of People with Cognitive Disabilities in Higher Education at the University of Costa Rica (PROIN, in Spanish), during 2021. A descriptive study with mixed focus was performed; a representative sample comprised of 86 students enrolled in PROIN was used for the quantitative approach, while the qualitative approach used a criteria sample along with an opinion sample, limiting size due to information overload. The survey, along with its corresponding questionnaire and the semi-structured interview, were used as data gathering techniques. It was evidenced that certain issues need to be readdressed, such as bleeding gums, the importance of preserving dental pieces, as well, the practice of flossing, which many students expressed difficulties doing. Good attitudes were found, such as dentist visits; however, access barriers for this population must be overthrown. This article showed the importance of training professionals in disabilities as well as developing oral health promotion programs aimed at people with cognitive disabilities.
SARS-CoV-2 collective immunity among the population of the Republic of Armenia
Authors: Popova Anna Yu. , Smirnov Vyacheslav S. , Egorova Svetlana A. , Vanyan Artavazd V. , Milichkina Angelika M. , Bakunts Nune G. , Drozd Irina V. , Abovyan Romella A. , Ivanov Valeriy A. , Melik-Andreasyan Gayane G. , Ramsay Edward Smith , Palozyan Gennady O. , Arbuzova Tatyana V. , Keshishyan Ara Sh. , Zhimbayeva Ouna B. , Petrova Olga A. , Gubanova Alexandra V. , Razumovskaya Alexandra P. , Totolian Areg A.
Published: April 2023

Background. The COVID-19 pandemic has become a substantial global health crisis, unparalleled in world history. Infection dynamics can have specific characteristics in different countries due to social, economic, climatic, or geographic factors. Aim: to study features of SARS-CoV-2 collective immunity among the Armenian population. Materials and methods. A cross-sectional, randomized study of collective immunity was carried out according to a program developed by Rospotrebnadzor and the St. Petersburg Pasteur Institute, taking into account WHO recommendations. The study was approved by the ethics committees of the National Center for Infectious Diseases (Armenia) and the St. Petersburg Pasteur Institute (Russia). A volunteer cohort was formed (N = 6057), randomized by age and region. The studys analysis included: shares and distributions of antibodies (Abs) to nucleocapsid (Nc) antigen (Ag) and receptor binding domain (RBD) S-1 Ag in the cohort; and quantitative determination of these Abs by ELISA. During the survey, a history of vaccination was indicated by 4395 people. Results. Overall seropositivity formed in the whole cohort (by April 14, 2022) was 98.6% (95% CI: 98.198.7). It did not depend on age, place of residence, or occupation. When quantifying Nc and RBD Abs, the proportions of volunteers with Nc Ab levels of 117 BAU/ml and RBD Ab levels of 22.6220 BAU/ml were the smallest, amounting to 6.9% (95% CI: 6.27.5) and 20.4% (95% CI: 19.421.4), respectively. With increasing serum concentrations (Nc 667 BAU/ml, RBD 450 BAU/ml), the proportions of individuals with the corresponding levels were 20.2% for Nc (95% CI: 19.221.3) and 54.2% for RBD (95% CI: 52.955.5). Vaccination coverage was 72.6% (95% CI: 71.573.7). The most frequently used were Sinopharm/BIBP (32.4%), AZD1222 (22.3%), and Gam-COVID-Vac (21%). The remaining vaccines (CoronaVac, mRNA-1273, BNT162b2, CoviVac) were used by 24.3% of vaccinated individuals. When summing vaccines by platform, it was found that: vector vaccines were used in 40.34% (95% CI: 33.5742.39) of cases; whole-virion vaccines were used in 26.83% (95% CI: 24.7632.20); and mRNA vaccines were used in 6.33% (95% CI: 4.848.91). Conclusion. The epidemic situation in Armenia by April 2022 was characterized by a high level of collective immunity, independent of age or regional factors. Vector and whole-virion vaccines have been used most widely.
Editorial Vol. 10, Issue 1.
Authors: De Gloria Alessandro
Published: April 2023

Editorial of Vol. 10, Issue 1, of the International Journal of Serious Games
Conducta gregaria irracional en crowdfunding de recompensa: experimento de campo
Authors: Comeig-Ramírez Irene , Ramírez-López Federico , Portilla-Salas Ferran
Published: April 2023

el crowdfunding de recompensa es una interesante alternativa de financiación para iniciativas emprendedoras en su etapa inicial. Entre los factores que facilitan el éxito en dichas campañas destaca el comportamiento gregario, es decir, la tendencia a imitar las decisiones de financiación de los anteriores mecenas. El efecto gregario, o de rebaño, se ha demostrado robusto en investigaciones anteriores como un acto racional que apoya campañas con mayor probabilidad de conseguir el objetivo de financiación impuesto, su éxito. En este artículo se va más allá de ese resultado empírico de la literatura previa y se analiza si el comportamiento gregario se produce en el crowdfunding de recompensa incluso sin factor racional, como simple imitación de un comportamiento anterior, independientemente de la motivación racional del éxito del proyecto. Para ello, se diseña y ejecuta un experimento en una campaña real de financiación de un proyecto cultural en la plataforma Verkami, la más potente para proyectos culturales en España. Este experimento de campo permite analizar la causalidad entre las decisiones de los mecenas anterioressobre el color de una recompensa y las elecciones de los mecenas siguientes. Los resultados muestran claramente un comportamiento gregario no racional en las elecciones de los siguientes mecenas en el crowdfunding de recompensa, que escogen mayoritariamente el mismo color que las aportaciones iniciales. El artículo confirma la importancia del componente no racional en la conducta gregaria en crowdfunding.
Clinical features of epilepsy course during COVID-19
Authors: Mikhailov V. A. , Sivakova N. A. , Idrisova Z. K. , Shova N. I.
Published: April 2023

Background. Currently, a great body of data regarding the link between epilepsy and novel coronavirus infection (NCI) has been accumulated. Numerous studies have paid a great attention to rise in frequency and severity of epileptic seizures as well as failure of remission in individuals suffering from epilepsy.

Objective: to study clinical and mental changes during NCI in patients with epilepsy.

Material and methods. Fifty patients with epilepsy were examined, who were divided into two groups depending on the NCI history: Group 1 (main) – 25 patients undergone COVID-19 in the period from 2020 to 2022; Group 2 (control) – 25 patients not undergone COVID-19 during the same period. Clinical-anamnestic and psychometric methods were used as well as the following scales and questionnaires: National Hospital Seizure Severity Scale (NHS-3), Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), Beck Depression Inventory (BDI), Medical Outcomes Study Sleep Scale (MOS-SS), Multidimensional Fatigue Inventory (MFI-20).

Results. In patients with epilepsy who had undergone COVID-19, there was a tendency for more frequent epileptic seizures and increased severity of seizure course. Among such patients, mild depression and more severe asthenia, cognitive impairment, moderate sleep disturbances were more common than in the control group.

Conclusion. The NCI pandemic has had a pronounced negative impact on the severity of epilepsy (the underlying disease).
The “Epilepsy and Paroxysmal Conditions” Journal Founder’s and Publisher's Statement
Authors: Dizhevskaya E. V. , Blinov D. V.
Published: April 2023

The Founder and Publisher became aware of a potential apparent conflict of interest – it is assumed that it is not entirely correct to continue to be the Editor-in-Chief at the “Epilepsy and Paroxysmal Conditions” Journal, being a member of the founders of an organization that has registered another journal with similar name. Therefore, the Founder of the “Epilepsy and Paroxysmal Conditions” Journal was forced to refuse further cooperation with the Editor-in-Chief. Information about a new Editor-in-Chief will be brought in a separate order. Also, informational support of any public organizations by the journal is suspended until the situation is clarified. The entire cycle of editorial processes is now fully controlled by the Irbis LLC. No changes in the operating team occurred. The “Epilepsy and Paroxysmal Conditions” Journal continues to be published as usual.
Use of mesh fixation device in inguinal hernia
Authors: Kumar Singhal Vinod , Alaswad Faris Dawood , Ojha Varsha , Vinod Singhal Vidher Varsha
Published: April 2023

Background: With attention to patient outcome after open inguinal hernia chronic inguinal region pain and discomfort are major complains due to nerve compression by sutures used for mesh fixation. Objectives to compare outcomes of mesh fixation with metallic versus delayed absorbable suture material in inguinal hernia through laparoscopic surgery.
Methods: This was prospective study conducted at department of general surgery in a Prime hospital, Dubai during the period of January 2022 to December 2022. Prior approval of local ethical committee was obtained. Total 100 male patients who underwent laparoscopic surgery were included in the study. Patients were split into two groups of 50 each. Metallic suture material (Tantallum 1-0) was used to fix the mesh in group 1 while mesh fixation was used in group 2 was completed with Vicryl 2-0, a delayed absorbable suture material. SPSS was used for analysis.
Results: There was appearance of post-operative pain in 20 patients, 10 patients, and 7 patients after 10 days, after 1 month and after 3 months, respectively in group 1 while for group 2, post-operative pain appeared in 12 patients, 4 patients, and 2 patients after 10 days, after 1 month and after 3 months, respectively. As such there was no statistically significant difference was found between two groups except for the appearance of the post-operative pain after 1 month (p<0.05).
Conclusions: The recurrence rates for the two approaches are statistically equivalent. As a result, delayed absorbable material may be an effective mesh fixation substitute.
Gastroduodenal gastrointestinal stromal tumour: a case series and review of literature
Authors: Abuji Kishore , Dahiya Divya , Banda Ashwin , Rana Surinder S. , Behera Arunanshu
Published: April 2023

Gastrointestinal stromal tumour (GIST) is the most common non-epithelial mesenchymal tumour and comprises 0.1-3% of all GI tract tumours. They express tyrosine kinase and are potentially malignant. Therefore, early diagnosis and surgical resection is the key for good outcome. This is a retrospective analysis of medical records of five patients of gastroduodenal GIST who were managed in the department of surgery between 2014 and 2015. Demographic profile, clinical presentation, laboratory parameters, diagnostic imaging, treatment details, histopathology and long-term outcome was analysed. Patients were followed up regularly in surgery outpatient clinic. Last follow up was in December 2022. All were female; three of them presented with melena and two with lump abdomen. Patients with gastric GIST underwent sleeve resection in two and antrectomy in one patient. Patient with duodenal GIST underwent excision of tumour with primary repair of duodenum. Fifth patient had metastatic duodenal GIST; Imatinib was started in view of irresectable disease at presentation. However, there was tumour progression and she expired seven months after treatment initiation with Imatinib. Histopathology revealed low grade GIST in two, intermediate grade in one and malignant in one.  Patient with malignant GIST received Imatinib for 2 years. All four patients are well on follow up with no sign of local and distant recurrence.
Challenging hernias: a case series of atypical hernias and review of literature
Authors: Shanthi P. S. , Kawarat Vikas C. , Shankar Adithi
Published: April 2023

Atypical hernias encompass the categories of flank, lumbar, spigelian, suprapubic and subxiphoid hernias among other rarer variants. These are considered to be tribulation in terms of their diagnosis and management, in that they are in proximity to the bone, which makes defect delineation, adequate mesh overlap, and fixation very challenging. Here, we would like to highlight a selection of our institutional experience with such hernias and their management. Within the institution, 6 cases of such rare hernias repaired within the last 6 months were chosen that posed a therapeutic challenge to the operating team. The cases described are- an interparietal port site incisional hernia, true lumbar hernia, flank region incisional hernia, a traumatic flank hernia, traumatic obstructed interparietal flank hernia, and a traumatic diaphragmatic hernia. All of the above cases were successfully managed by our team by a combination of abdominal wall reconstruction and mesh repair and have not reported any post-operative complications in the follow up period. Literature regarding rare hernia repairs is becoming more exhaustive by the day. However, the likelihood that we encounter such cases in practice is still less. Hence, it is essential to further the knowledge about management of such complex hernias and make an informed decision tailored to the patient’s requirements.
A case report on recurrent subphrenic abscess with pulmonary tuberculosis
Authors: Gayathre S. P. , Kumar R. Niranjan , Silambuselvi K.
Published: April 2023

Subphrenic abscess though a common presentation itself encountered in surgical practice due to various cause, a tubercular subphrenic abscess in the absence of coexisting tuberculous abdomen presenting as a complication of pulmonary tuberculosis is extremely rare. Only a very few cases have been reported as an extrapulmonary manifestation of tuberculosis so far. We report a case of isolated sub-diaphragmatic abscess which responded well with anti-tuberculous therapy despite all other interventions.
Rare presentation of gastric outlet obstruction with jejunal impaction of gall stones-the Bouveret’s syndrome
Authors: Ranjan Ravi , Saurabh Gyan , Singh Ranvir
Published: April 2023

Gall stones related complications are very common in the world, Bouveret’s syndrome is one of the rare complications (1-3%). Bouveret’s syndrome presents a diagnostic and therapeutic challenge. We present a rare case of an 80-year-old lady diagnosed with gastric outlet obstruction with jejunal impaction of gallstones, because of a gallstone impacted in the jejunum 50 cm from duodenojejunal flexure. The patient was operated on with enterotomy and retrieval of gall stones impacted in the jejunum, with roux en y gastrojejunostomy drainage procedure, the gastro-duodenal fistula was left in situ, because of high risk and unstable general condition of our patient intra-operatively. The patient had multiple pre-existing pre and peri-operative comorbidities, fortunately, our patient recovered and our patient was discharged on 21st postoperative days. Identifying Rigler’s triad symptoms is synonymous with diagnosing Bouveret’s syndrome. However, classical Rigler’s triad is present in only 40% of cases, hence alertness and a high degree of suspicion are required to differentiate Bouveret’s syndrome from other mechanical causes of gastric outlet obstruction. The atypical cases of Bouveret’s syndrome present a challenge to the surgeon for early diagnosis and therapeutic surgical management.
Gastric outlet obstruction secondary to peptic ulcer disease in a case of abdominal Koch’s
Authors: Bakhshi Girish , Nagwani Pooja , Arora Eham , Dhanorkar Tanay
Published: April 2023

Gastroduodenal tuberculosis (TB) presenting as gastric outlet obstruction is rare and often misdiagnosed, it is usually secondary to pulmonary tuberculosis and is often associated with HIV infection. Gastro-duodenal involvement is rarer disease (1%) in abdominal TB. We report a case of a 43-year-old male with no evidence of pulmonary tuberculosis and retroviral infection with complaints of abdominal pain since 4 months and features of gastric outlet obstruction, contrast enhanced computed tomography (CECT) and magnetic resonance cholangiopancreatography (MRCP) were suggestive of pneumobilia, and on endoscopy bilioenteric fistula was confirmed also features of pan gastritis and duodenitis with concentric wall thickening noted at D1 and D2, although histological examination of biopsies showed no evidence of malignancy or tuberculosis. The diagnosis was established after surgery, when a specimen of an enlarged lymph node was sent for histopathological examination (HPE) and GeneXpert showed the presence of giant cells and caseating granuloma. The surgery performed was Roux-en-Y gastrojejunostomy. In this patient the rare gastroduodenal location of tuberculosis occurred as primary disease in the absence of other organ involvement. To the best of our knowledge this has been the first case reported as gastric outlet obstruction with bilioenteric fistula due to gastroduodenal tuberculosis.
Definitive or palliative treatment: case report of cancer breast survivor with ovarian mass
Authors: Lakhera Kamal Kishore , Kumar Naina , Patel Pinakin , Singh Suresh , Kumar Arjun , Singhal Pranav , Singh Gora Bhoopendra
Published: April 2023

Cancers survivors with second tumour mass. The difficult thing in these situations is definitive diagnosis. One sentence which shapes the future of a patient-a steep see saw of definitive and palliative treatment. What saves the clinician in this scenario is the immunohistochemistry (IHC). It single handedly brightens the path and leads to conclusion. This case report demonstrated the same in breast cancer survivor.
A review on specific and sensitive analytical method development and validation
Authors: Nazmus Sakib Chowdhury MD
Published: April 2023

A specific and sensitive analytical method development and validation plays an important role for building drug discovery, product development and manufacturing of pharmaceuticals. The main purpose of this review article is to check the report of specific and sensitive analytical method development and validation parameters involved in different pharmaceuticals manufacturing. Development of sensitive analytical method is extremely much significant because it ensures product efficacy and product quality. The sensitive analytical method development and validation is the process of proving that the analytical method meets the analytical acceptance criteria and it can use to measure the concentration of target molecule at its specification limit. The aim of method development is to produce a reproducible specific and sensitive analytical method in a cost effective manner. The parameters of validation involved are introduced as specificity, method precision, accuracy, linearity, limit of detection (LOD), limit of quantitation (LOQ), ruggedness, robustness and system precision of the target molecule.
The effects of feeding with organic waste by terrestrial isopod Philoscia Muscorum on enzyme activities in an incubated soil
Authors: MUMİNOVA Sholpan S. , BAYADİLOVA Gulsun , MUKHAMETZHANOVA Oryngul , SEİLGAZİNA Saule M. , ZHUMABAYEVA Roza , RVAİDAROVA Gulnissam
Published: April 2023

Soil fauna are important biological factors that affect litter decomposition and play an important role in the release of nutrients and improve soil enzyme activities. This study focused on the effects of isopods on enzymatic activities of soil. Lab experiments were conducted to assess the influence of terrestrial isopod Philoscia Muscorum on enzyme activities during the incubation. In Lab experimental food sources from wheat straw were prepared. Dehydrogenase, urease, alkaline phosphatase and arylsulphatase activity in soil treated with different number of isopods with wheat straw were determined in 28 days incubation. Results showed that the presence of isopods significantly increased (P