bluuebunny/crossref_metadata_2025 huggingface dataset:
PARTISIPASI MASYARAKAT DALAM PENGELOLAAN HUTAN KEMASYARAKATAN (HKm) TANDUNG BILLA DI KELURAHAN BATTANG KOTA PALOPO
Authors: Witno Witno , Maria Maria , Supandi Dicky
Published: February 2022

In an effort to realize the concept of sustainable forest management, it is necessary to involve the community around the forest as the main actors who often interact with the forest. In this case, the concept in question is the concept of community participation. This study aims to determine the participation of forest communities in the existence of community forests. This research was conducted in Battang Village, West Wara District, Palopo City, South Sulawesi Province. Data was obtained directly through surveys and direct field observations, data collected through the observation method and semi-structured interviews were processed and clarified according to the research objectives and then analyzed using qualitative data analysis. The results obtained by community participation in community forestry are the lack of community participation which initially numbered 137 people, only 35 people left who were active due to contradictory plans and conditions in the field that triggered problems in the group.
The Energy Kuznets Curve: Evidence from Developed and Developing Economies
Authors: Moosa Imad A. , Burns Kelly
Published: February 2022

The energy environmental Kuznets curve is effectively an environmental Kuznets curve augmented by adding one or more energy-related variables. We suggest that the energy Kuznets curve (EKC) can be estimated separately from the conventional environmental Kuznets curve as a quadratic function of income. It is demonstrated that the environmental Kuznets curve implies and is implied by the EKC. The empirical results show consistently that both the environmental and EKC are valid for developed (high income) countries but not so for developing (low income) countries where the relations are positive and monotonic. The importance of considering energy consumption in conjunction with the environmental Kuznets curve is that economic growth on its own does not put an end to environmental degradation unless the underlying country is on the downward-sloping sections of both the environmental and EKC.
ANÁLISE DA EFICIÊNCIA DO GERENCIAMENTO DE RESÍDUOS SÓLIDOS EM PROPRIEDADES RURAIS DE PEQUENO PORTE EM TUPI PAULISTA - SP
Authors: Simionatto Henzo Henrique , Esturaro Leila Maria Couto
Published: February 2022

The management of solid waste are practices provided for in the articles of Law No. 12,305 / 10, entitled National Solid Waste Policy. The objective of this work was to analyze whether solid waste management is efficient in small rural properties in the city of Tupi Paulista - SP. For this, it was necessary to: carry out the mapping of rural properties that practiced selective collection between the years 2019 and 2020; work in environmental education; collect recyclable materials and, finally, quantify the waste generated in the period analyzed, and then compare between 2019 and 2020. This study concludes that, even with the increase in rural properties that joined selective collection, there was a constant in the relationship for the average amount of waste generated per property, this was possible due to the environmental education work developed throughout the study, enabling the population to participate in the planning and management of waste. It is also observed that this work made it possible to improve the quality of the local environment, with a reduction in the volume of solid waste in rural properties through selective collection.
EASY ASSISTANT: UMA FERRAMENTA DE AUXÍLIO PARA O DESENVOLVIMENTO DE CHATBOTS DE DOMÍNIO ESPECÍFICO
Authors: Moreira Alexandre , Pazoti Mário Augusto , Siscoutto Robson Augusto
Published: February 2022

Intelligent systems are mainly linked to the act of bringing more and more support to people. Currently, there is a growing use of elements related to the machine learning capacity, that is, Artificial Intelligence (AI). In AI, chatbots stand out, personalized and virtual agents with a certain emotional and cognitive level, usually employed in collaborative, social or learning systems, in order to offer some service with persistent and strongly relational interaction to users. Developing such an agent is not trivial. A chatbot that provides consistent and immersive communication requires several techniques, sometimes even complex,related to natural language processing, understanding and generation, which involve classification of entities, objectives, among others; also self-healing to avoid conversation inconsistencies and loss of context. Therefore, this work presents a web tool that allows the user to develop, train and customize their chatbot virtual agent. This agent uses two training and response models based on recovery and generative models, built on neurais networks that manipulate a database defined by the user. The tool was tested and evaluated in order to qualify its accuracy, which proved to reach its goals, as well as allow the creation of a personalized chatbot.
JORNALISMO ONLINE É O CAMINHO? UMA ANÁLISE DA TRANSIÇÃO TECNOLÓGICA DOS JORNAIS IMPRESSOS
Authors: Fabrício Joiceli dos Santos , Pereira Jaiane Aparecida , Gruba Marcia Cristiane , Carstens Danielle Denes dos Santos
Published: February 2022

Este estudo teve por objetivo analisar de que forma as novas tecnologias estão impactando os jornais impressos no estado do Paraná. A partir de uma abordagem da teoria sociotécnica da inovação, foi realizada uma análise sobre as transformações tecnológicas ocorridas nos jornais impressos de pequeno e médio porte do interior do estado do Paraná. A metodologia utilizada foi qualitativa descritiva em duas fases. Na primeira fase foi enviado um questionário estruturado para os proprietários com 25 questões fechadas que foram disponibilizadas na plataforma online do Google Drive. A segunda fase consistiu de entrevistas em profundidade com doze proprietários gestores de jornais impressos pertencentes à Associação dos Jornais Diários do Interior do Paraná (ADI-PR). Como resultados observou-se que o impacto das transformações tecnológicas nas empresas pesquisadas é muito amplo, tendendo a modificar o seu modelo de negócio de forma profunda. Os resultados mostram ainda que mesmo com as transformações tecnológicas com impacto radical, como a Internet, existe uma co-evolução do jornal impresso, que se modifica de forma gradual e incremental e traz novas perspectivas para a adaptabilidade setorial. Ademais, observou-se que o maior desafio é o de monetizar o acesso aos jornais online, processo inerente à transição tecnológica pela qual o setor passa.
“UM PINGO DE FEIJÃO EM UMA PANELA DE ARROZ”: RACISMO, TRAJETÓRIAS E PERSPECTIVAS DE MULHERES NEGRAS NO PODER JUDICIÁRIO
Authors: Machado Priscila Silva Ximenes , Miranda Adílio Renê Almeida , Rezende Alicia Madrid Cesar , Brito Joice Zentner de
Published: February 2022

Dentro das discussões sobre a questão racial no Brasil, pode-se observar como temática emergente a discrepância representativa nos espaços e posições de poder ocupados por pessoas negras, principalmente, mulheres. Nesse sentido, o presente artigo visa compreender a trajetória de mulheres negras do judiciário brasileiro, no que se refere às vivências de racismo, conquistas e barreiras enfrentadas. Para tanto, foi realizada uma pesquisa qualitativa por meio de entrevistas semiestruturadas. Os relatos apresentados sobre a fase acadêmica e no exercício da profissão no judiciário mostram como a sensação de não pertencer a determinado espaço faz parte da vida dessas mulheres. As experiências vividas dentro do judiciário apontam situações de racismo vividas pelas entrevistadas, muitas vezes de maneira velada, outras de forma mais ostensiva. Os achados da pesquisa contribuem para se pensar sobre a necessidade de uma mudança estrutural no judiciário, no que se refere às questões raciais, não apenas por meio de política de cotas raciais, mas, sobretudo, com criação de espaços de discussão e debates sobre o racismo institucional no poder judiciário.
Gêneros do discurso em cursos de Licenciaturas de Santa Catarina: o que dizem os professores
Authors: Koerner Rosana Mara
Published: February 2022

A pesquisa que aqui se apresenta se inscreve nos estudos de letramento acadêmico. O objetivo da análise é identificar quais os gêneros discursivos utilizados pelos professores para e em suas práticas pedagógicas. Foram analisadas respostas a um questionário on-line e a entrevistas semiestruturadas realizadas com professores de cursos de licenciatura de universidades de Santa Catarina. Trata-se de excerto de um estudo mais amplo, sob a temática do letramento acadêmico. Com base nas proposições teóricas dos estudos sobre gêneros, especialmente na esfera acadêmica (FISCHER; DIONÍSIO, 2011; SILVA; CASTANHEIRA, 2019), a análise dos dados evidenciou que, além dos gêneros típicos da esfera acadêmica, há outros sendo trabalhados, muitos deles com algum propósito pedagógico. Também foi possível perceber certa relação entre a leitura e a escrita que os professores fazem para a sua prática pedagógica e aquela que solicitam aos seus estudantes. Considerando as orientações nas DCN (2019) para uma prática que implique o uso dos gêneros discursivos em todas as licenciaturas, faz-se necessário discutir com os professores formadores de professores como tais orientações se fazem presentes em suas aulas.
Letramento acadêmico: percurso da construção da identidade profissional docente em Letras-Português em formação inicial
Authors: Pereira Selma Lúcia Assis
Published: February 2022

O presente artigo tem como finalidade realizar uma reflexão sobre o percurso da construção da identidade profissional docente no curso de Letras-Português, em formação inicial, no Instituto Federal de Educação do Espírito Santo (Ifes) campus Venda Nova do Imigrante - ES, relacionando esse percurso com a formação acadêmica e o Estágio Supervisionado nos anos finais. Diante disso, partimos da problematização: que docente em Letras-Português o Ifes Campus Venda Nova do Imigrante espera formar? Para isso, discutimos à luz da fundamentação teórica baseada em Pimenta e Lima (2017), Gatti (2016), Benevides (2006), Hall (2003), Bauman (1998,2005), Nóvoa (1988), Fischer (2007), Marcelo (2009), Volochinov (2003) e Bakthin (2003), isto é, partiu-se de reflexões sobre construção da identidade docente em formação inicial e humanização do Curso de Licenciatura em Letras-Português em uma instituição tecnicista. Como percurso metodológico, realizou-se um acompanhamento dos relatos de experiências dos acadêmicos, foram selecionados dois relatos de experiência sobre o percurso do Estágio Supervisionado nos anos finais. Por fim, concluiu-se que para que haja um processo formativo eficaz, espera-se um acompanhamento sistematizado do professor-orientador, professor-tutor e acadêmicos a fim de que possam iniciar um percurso de identidade profissional docente.
Case Report of Torsion of Cryptorchid Testis Causing Abdominal Pain
Authors: Newhouse Hannah , Minardi Joseph , Rawlins Frederic
Published: February 2022

Introduction: A myriad of pathologies can cause abdominal pain. Genitourinary causes including testicular torsion must be considered.
Case Report: In this report, we present a 17-year-old male evaluated in the emergency department for lower abdominal pain. After physical exam, computed tomography, and ultrasound were completed, torsion of undescended testicle within the inguinal canal was diagnosed. Surgical exploration revealed a twisted, ischemic testis, and subsequent orchiectomy was performed.
Conclusion: This case highlights the importance of a thorough genitourinary exam in patients with lower abdominal pain.
Nausea and Dyspnea on Exertion: Left Ventricular Free-wall Rupture
Authors: Wilson Juliana , Mendes Matthew , Betz Marian , Mingo Juan
Published: February 2022

Case Presentation: A 53-year-old female presented to the emergency department with three days of nausea and dyspnea on exertion after using methamphetamine. Initial electrocardiogram revealed an ST-elevation myocardial infarction. While awaiting transfer to the cardiac catheterization lab the patient suffered a witnessed cardiac arrest. During resuscitative efforts an enlarging pericardial effusion on point-of-care ultrasound led to the detection of a left ventricular free-wall rupture (LVFWR). This case illustrates the progression of a left ventricular free-wall rupture using point-of-care ultrasound.
Discussion: Left ventricular free-wall rupture has a low incidence rate in the setting of an acute myocardial infarction. Ultrasonography is the tool of choice for detecting a LVFWR.
Delayed Tension Pneumocephalus Following Frontal Sinus Fracture
Authors: Ortiz-Galloza Eddie , Arechiga Bianca , Heer Jagdipak , Quesada Daniel
Published: February 2022

Case Presentation: We describe a delayed case of tension pneumocephalus in a newly altered patient 21 days status-post auto-vs-pedestrian accident. After her initial hospital course, the patient was discharged to an acute rehabilitation facility in stable condition with Glasgow Coma Scale 15. The patient returned to the emergency department for an acute change in mental status.
Discussion: Tension pneumocephalus is a neurosurgical and otolaryngological emergency.
Assessment of Correlation Between Brain Function Index and Three Common Sedation Scales Used in Intensive Care Unite
Authors: Shokoh Ali , Mousavi Mirzaei Seyed Mohammad , Khalesi Alireza , Ganjifard Mahmoud
Published: February 2022

Background: This study aimed to evaluate the correlation of the brain function index (BFI) with three criteria of consciousness (Glasgow, Richmond, and FOUR score) in the intensive care unit. Methods: We enrolled patients aged over 15 years who required no muscle relaxants and had no hearing and visual impairment, mental retardation, mental disorder, hemodynamic instability (MAP < 60 mmHg), and hypoxia (SpO2 < 90%), as well as patients with no brain electrical activity disorders such as epilepsy and focal brain disease, and those who had not undergone anesthesia and surgery for the past 24 hours. Results: All ICU patients were enrolled in the study in the autumn and winter based on inclusion and exclusion criteria (n = 85). During 24 hours, BFI and three clinical criteria of sedation and consciousness including RASS, GCS, and FOUR score were assessed three times with a minimum of four-hour intervals. Among the patients, 45 (52.9%) were males, and 40 (47.1%) were females; 24 (28.2%) patients were under 40 years of age, 13 (15.3%) patients were between 41 and 60 years old, and 48 (56.5%) patients were over 61 years old. There was a significant positive relationship between the BFI score of ICU patients and the score of patient consciousness based on RASS, FOUR score, and GCS. The correlation of BFI with the FOUR score was higher than those with the other two criteria. Conclusions: Objective criteria for assessing the consciousness level such as BFI are sufficiently accurate and can be used instead of clinical criteria to assess the level of consciousness in special wards.
At Any Rate
Authors: Nancy Jean-Luc , Morin Marie-Eve , Holloway Travis ,   DePaul University
Published: February 2022

What does the word “value” mean? On the one hand, absolute value is an excellence that is beyond measure. On the other hand, value can also be interpreted as price, as what can be measured and exchanged. In both cases, value lies in relation and is of the same order as sense. But what is the relation between these two senses of value? And why is it so difficult to hold the two apart?
Intravenous Immunoglobulin Nonresponse in Pediatric Patients Treated for Kawasaki Disease at a US Hospital
Authors: Smelser Lauryn , Vejzovic Jennifer , Johnson Emma , Schultz Jordan , Wood Kelly E.
Published: February 2022

OBJECTIVE

Kawasaki disease (KD) is an acute febrile childhood vasculitis with a predilection for the coronary arteries treated with IVIG. In the United States, scoring systems to identify children at high-risk of persistent fever after initial IVIG treatment are lacking. Our study attempts to identify variables associated with IVIG non-response.

METHODS

Retrospective review of patients ages 0 to 18 admitted to an US academic children's hospital between August 1, 2010, and August 31, 2019, with the diagnosis of acute KD who received IVIG during hospitalization.

RESULTS

A total of 64 patients were included, 73% male and 66% Caucasian with a mean age of 3.67 ± 3.35 years. Forty-eight patients (75%) received 1 dose of IVIG, and 16 (25%) received 2 doses of IVIG. The groups did not differ significantly at baseline. None had coronary artery aneurysms detected during hospitalization. Older age, female sex, Caucasian compared with African American race, leukocytosis, and hyponatremia were associated with a higher likelihood of IVIG non-response but none reached statistical significance. Patients who received ibuprofen (n = 26) were more likely to be IVIG non-responsive (p < 0.05). Aspirin dosing varied but was not predictive of IVIG non-response.

CONCLUSIONS

In this study, risk factors to predict IVIG non-response in patients treated for KD were not identified. IVIG non-response was significantly more common in those receiving ibuprofen during the acute treatment phase. Larger studies are needed to validate the association of ibuprofen administration and IVIG non-response in patients with KD.
Implementation of Interprofessional Rounds Decreases Neonatal Abstinence Syndrome Length of Stay
Authors: McCarty Teri , Braswell Erica
Published: February 2022

OBJECTIVE

Neonatal abstinence syndrome (NAS) occurs due to abrupt discontinuation of chronic fetal exposure to substances used by the mother during pregnancy. As the incidence of NAS continues to increase, medical teams are evaluating strategies to reduce length of stay (LOS). Increased LOS contributes to poorer mother-infant bonding and neurodevelopmental outcomes as well as increased health care cost. As part of an ongoing quality improvement project, the objective of this study was to determine if formal interprofessional rounds affected LOS for infants with NAS.

METHODS

This was a retrospective analysis at a single hospital system to determine if interprofessional rounds had an impact on NAS LOS. On February 5, 2016, introduction of formal weekly interprofessional NAS-specific rounds occurred in addition to daily patient care rounds. Every patient with opioid exposure undergoing Finnegan scoring, treated with weight-based morphine, and >35 weeks gestation was included. Data were collected on LOS and length of therapy for eligible patients. This study evaluated the impact of interprofessional rounds on LOS 17 months after its implementation compared with 13 months immediately preceding.

RESULTS

Among the 119 infants (51 pre and 68 post) meeting inclusion criteria, the median LOS for the post-rounds group was significantly shorter than the pre-rounds group (13 vs 16 days, p = 0.001). The median length of therapy (morphine with or without clonidine) was also significantly shorter in the post-rounds versus the pre-rounds group (8 vs 12 days, p = 0.001).

CONCLUSIONS

Formal weekly interprofessional NAS rounds decreased LOS and length of therapy.
Shared Memory, Odours and Sociotransmitters or: "Save the Interaction!"
Authors: Candau Joël
Published: February 2022

Collective memory, social memory, professional memory: although these notions are in current use when we name the shared (or assumed to be shared) representations of the past, they are very ambiguous. The point at issue is to show how memories can become common to some or to all members of a group. In this paper, I shall base my arguments on the simplest situation imaginable: The sharing of a memory of an olfactory experience by two individuals, namely  one of my informants – a gravedigger – and myself.We can try to explain this shared olfactory memory, or the imagination of this sharing, by taking two facets into consideration. First of all, we must learn to take seriously those few seconds when a shared experience of the sensory world took shape between the anthropologist and his informant. Secondly, we must attempt to answer both of the following questions: what is the nature of this sharing? And what conditions make it possible? In the first part of this text, I examine the issue of the nature of sharing by weighing up its aspects as I consider protomemory, memory and metamemory. In the second part, I outline one of the essential conditions of sharing: the existence of what I call sociotransmitters. For the most part, my attention remains focused on that particular moment when the gravedigger said, “Smell this!”, and when what was at stake was to save the interaction.
Experiencing (Pereživanie) as Developmental Category: Learning from a Fisherman who is Becoming (as) a Teacher-in-a-Village-School
Authors: Jóhannsdóttir Thurídur , Roth Wollf-Michael
Published: February 2022

In this study, we take up L. S. Vygotsky’s challenge to study learning and development in terms of categories, irreducible units that preserve the characteristics of the whole (society). One such category (unit) is experiencing [pereživanie], a process that integrates over the relation of person and environment. Using a case study from Iceland, we theorize the process of “becoming as a teacher-in-a-village school” in terms of experiencing [pereživanie]. The case describes a stage of development in the life of a person who becomes a teacher and then experiences a developmental trajectory very different from his previous life as a fisherman. This is an aspect of  teacher education that  is hardly (if ever) described in the teacher education literature which tend to be concerned with events after a person has entered a professional program or after a person has begun teaching. We discuss the implications of taking experiencing [pereživanie] as the developmental unit for theory and the practice of teacher education and development.
Empathic Actors Strengthen Organisational Immunity to Industrial Crisis: Industrial Actors’ Perception in Nepal
Authors: Bhattarai Raj Kumar
Published: February 2022

This paper aims to understand the kind of activities that industrial actors develop in order to protect their enterprises during industrial crisis conditions. A series of political unrest, insurgency, economic turmoil, deadly earthquakes, and economic embargo at the Indo- Nepal boarder escalated the industrial crisis in Nepal. The quest for sustainability of enterprises during the enduring nature of the crisis stimulated for a more detail conversation and survey. A perceptual survey of industrial actors accompanying conversation therein indicates that trade union and association leaders develop positive attitude and advance specific activities for protecting their enterprises during industrial crisis conditions. The study finds that an empathic nature helps to develop a positive attitude among the industrial actors, which seems contributory for enterprises to survive during crisis conditions. The actors tend to positively perceive significance of specific activities under the conditions of difficulties and hardships and enhance immunity to the industrial crisis. This paper argues that the empathic nature of the industrial actors becomes more effective to safeguard the pluralistic interests of the stakeholders of the enterprise than the self- centric nature of the actors. The actors are not only engaged in safeguarding their claims on the industry but are also contributing—beyond their routine work—positively to strengthen the enterprise immunity during difficulties. This paper concludes with an insight of shifting managerial attention from the generic concepts like cost minimisation and product differentiation to the concepts of regularity in supply of goods and services in the business network by expanding the scope of industrial relations vertically and horizontally. The empathic nature of industrial actors enhances the effectiveness of the general system theory and social network theory by developing understanding of the role of industrial actors’ relations in sustaining and operationalizing a business network under organizational crisis conditions.
The Evolution of a Practice in Trialectic Space: An Approach Inclusive of Norms and Performance.
Authors: Torres García Miguel
Published: February 2022

Practice theory has lately taken a turn towards modelling the evolution of practices, which appear situated at the centre of the study of social action. I argue in this paper, following previous criticisms, that such centrality can be revised in order to better incorporate elements of agency and normativity, which are much determinant of the emergence and development of practices. The aim of this paper is to propose an alternative heuristic which advances on lefebvrean trialectics, in order to better account for process in the study of practices. For this I rely on previous concepts from anthropology and sociology, such as fetishisation, ritualisation and bricolage. A relevant case study is merely outlined in order to illustrate how such a conceptual framework can identify agencies and situate practices in relation to power structures and performance at an early stage within the research process.
The Aesthetic as an Aspect of Praxis
Authors: Axel Erik , Hermansen Janni Berthou , Jacobsen Peter Holm
Published: February 2022

Commonly the aesthetic is understood as sensuous private pleasure, which other people cannot experience, but maybe talk about, and on the other hand as created by individual artists' talents. We will attempt to bring the aesthetic back into praxis by arguing that aesthetic experience is tied to Gibson’s notion of perceptual systems. The article builds on observations of a design project for a community center in a Danish village. We argue that the aesthetic is shared pleasure resulting from struggles by participants in praxis, where aesthetic, material, functional, ethical, political, and economic aspects are formed by each other in a dialectic process. The struggles are found in the community council's reasons for starting the process, in the design and construction process and the use of the results. This means that descriptions of the aesthetic appearance of buildings should incorporate relevant discussions and struggles of the design, construction and use of the building, and that aesthetic experience is enriched the more aesthetic experience it is based on. It also means that the key to a fruitful ongoing collaborative process producing good aesthetic designs comes from managing together the many aspects of praxis in an open way.
Compensation of Intellectual Disability in a Relational Dialogue on Down Syndrome
Authors: Souza Fabiola Ribeiro de , Souza Fabiola Ribeiro de , Barbato Silviane Bonaccorsi
Published: February 2022

The historical-cultural theory of Intellectual Disability (DI) overcompensation/compensation is referenced in several studies, but little empirical evidence is presented to corroborate this thesis. In this work, 13 current studies were analysed about the behavioural profile of people with Down syndrome (DS), a case of neurobiological ID, published in the last 15 years, in order to verify the possibility of dialogue with the theorizing about compensation. Despite contributing to an up to date understanding of DS, the results point to similarities between different scientific traditions allowing discussions regarding methodologies, data interpretation, language comprehension, and the impact of the studies for school inclusion and the development of people with ID/DS. It is concluded that the theorization in question is pertinent to developmental studies, dialogues with other perspectives and that its progress depends on investigations directed to the affective motivators/emotions of the person with ID/DS by means of more interpretative methodologies.

Keywords: Down syndrome, compensation, behavioural profile, Intellectual Disabilities Development
Educating Resilient Social Work Professionals
Authors: Jydebjerg Camilla Sabroe , Madsen Karin Brantbjerg , Christensen Michael
Published: February 2022

This article deals with the concept of vulnerability in social work and how social work students understand the concept of professionalism. The article is based on an empirical study of social worker students and on analysis of the literature used in the education. Theoretically, the article rests upon vulnerability theory as elaborated by Martha Fineman. The analysis suggests that the social worker students share an understanding of the client as vulnerable, and of the social worker as not vulnerable. This entails a view that the social worker is objective and somewhat distanced from his/her clients. The article argues that this understanding runs the risk of producing non-reflexive social work practitioners that are not aware of their own vulnerable position. In conclusion, we state that an understanding of professionalism centred on a shared vulnerability of all beings could bridge the often-used dichotomous understanding of the social worker as either “helper” or “authoritative bureaucrat” and thus lead to a more resilient concept of professionalism.
‘Boundary Encounters’ as a Place for Learning and Development at Work
Authors: Kerosuo Hannele
Published: February 2022

Care for patients with multiple illnesses is often provided by several professionals from different parts of the health care system. In these cases, there seem to arise new demands for the communication and the cooperation between different professionals in the primary and the specialized care. In this paper, I shall describe how these challenges are met in an encounter which is a part of interventions called “Implementation Laboratories”. In these encounters, a new tool (care agreement) and a new practice (care negotiation) are introduced and elaborated in internal-medicine patient care. I conceptualized the Implementation Laboratories as “border zones” where the learning processes between different communities are intensified. Learning in the Implementation Laboratories resembles learning at the Boundary Crossing Laboratory described by Engeström, Engeström &Vähäaho (1999a; 1999b). It is interwoven into the process of analyzing problems, planning and testing of solutions in order to improve the medical patient care. Learning appears as collisions between the different perspectives of the patient and professionals of different organizations, and may sometimes lead to reconstruction of boundaries.
Reframing the Collegiate Facilities Arms Race: The Looming Impact of NIL and Conference Realignment
Authors: Petersen Jeffrey C. , Judge Lawrence W.
Published: February 2022

Amidst the backdrop of an ongoing global pandemic, the summer of 2021 brought forth two events teetering the Division I college sport landscape at the precipice of unprecedented change due to two fundamental shifts: the first being the opening of revenue streams to collegiate athletes through use of name, image and likeness (NIL), and the second being the latest round of athletic conference realignment. With the impacts of these changes just beginning to be manifested, it is important to consider how these potentially seismic shifts in the collegiate landscape may influence existing issues of prior scholarly examination as well as potential new areas of research. As such, the purpose of this paper is to identify areas of potential future research and inquiry associated with the NIL and conference realignment that could be addressed from the facilities perspective.
Bots in software engineering: a systematic mapping study
Authors: Santhanam Sivasurya , Hecking Tobias , Schreiber Andreas , Wagner Stefan
Published: February 2022

Bots have emerged from research prototypes to deployable systems due to the recent developments in machine learning, natural language processing and understanding techniques. In software engineering, bots range from simple automated scripts to decision-making autonomous systems. The spectrum of applications of bots in software engineering is so wide and diverse, that a comprehensive overview and categorization of such bots is needed. Existing works considered selective bots to be analyzed and failed to provide the overall picture. Hence it is significant to categorize bots in software engineering through analyzing why, what and how the bots are applied in software engineering. We approach the problem with a systematic mapping study based on the research articles published in this topic. This study focuses on classification of bots used in software engineering, the various dimensions of the characteristics, the more frequently researched area, potential research spaces to be explored and the perception of bots in the developer community. This study aims to provide an introduction and a broad overview of bots used in software engineering. Discussions of the feedback and results from several studies provide interesting insights and prospective future directions.
Nontargeted and targeted metabolomics approaches reveal the key amino acid alterations involved in multiple myeloma
Authors: Yue Lingling , Zeng Pengyun , Li Yanhong , Chai Ye , Wu Chongyang , Gao Bingren
Published: February 2022

Purpose

Multiple myeloma (MM), a kind of malignant neoplasm of clonal plasma cells in the bone marrow, is a refractory disease. Understanding the metabolism disorders and identification of metabolomics pathways as well as key metabolites will provide new insights for exploring diagnosis and therapeutic targets of MM.

Methods

We conducted nontargeted metabolomics analysis of MM patients and normal controls (NC) using ultra-high-performance liquid chromatography (UHPLC) combined with quadrupole time-of-flight mass spectrometry (Q-TOF-MS) in 40 cases of cohort 1 subjects. The targeted metabolomics analysis of amino acids using multiple reaction monitoring-mass spectrometry (MRM-MS) was also performed in 30 cases of cohort 1 and 30 cases of cohort 2 participants, to comprehensively investigate the metabolomics disorders of MM.

Results

The nontargeted metabolomics analysis in cohort 1 indicated that there was a significant metabolic signature change between MM patients and NC. The differential metabolites were mainly enriched in metabolic pathways related to amino acid metabolism, such as protein digestion and absorption, and biosynthesis of amino acids. Further, the targeted metabolomics analysis of amino acids in both cohort 1 and cohort 2 revealed differential metabolic profiling between MM patients and NC. We identified 12 and 14 amino acid metabolites with altered abundance in MM patients compared to NC subjects, in cohort 1 and cohort 2, respectively. Besides, key differential amino acid metabolites, such as choline, creatinine, leucine, tryptophan, and valine, may discriminate MM patients from NC. Moreover, the differential amino acid metabolites were associated with clinical indicators of MM patients.

Conclusions

Our findings indicate that amino acid metabolism disorders are involved in MM. The differential profiles reveal the potential utility of key amino acid metabolites as diagnostic biomarkers of MM. The alterations in metabolome, especially the amino acid metabolome, may provide more evidences for elucidating the pathogenesis and development of MM.
Case Report on Wilm’s Tumor in Children
Authors: Borkar Saurabh , Maurya Archana
Published: February 2022

Introduction: Wilms tumor is the most frequent kind of kidney cancer in kids. It is responsible for around 6% of all tumors in children. In children under the age of 15, the incidence is 7.6% cases per million, with 75% of cases occurring before the child reaches the age of five. A variant term for wilms tumor is nephroblastoma. It is most widespread between the ages of three and four, after which it becomes much less frequent.

Clinical Findings: Wilms tumor in children produces one or more of the following signs and symptoms:

Abdominal pain

Increasing abdominal girth

Lack of appetite

Fever

Blood in the urine

Nausea or vomiting.

Constipation

Shortness of breath

Diagnostic Evaluation:  Increase abdominal girth, pain, fever, vomiting, cried at the time of urination, hematuria, black stool, pallor, hypertension and moderate microcytic anemia (Iron deficiency).

Ultrasonography: Splenomegaly

Therapeutic Investigation: X- ray of abdomen and chest, IVP, USG, MRI, CT scan, renal function test and urine analysis, liver function test bone marrow study, and histology

Outcome: After treatment, the child shows great improvement, his fever, abdominal pain, blood in urine is minimized and his Hb level is increased from 9gm% to 11.1gm%.

Conclusion: A female child of 11 years from admitted to pediatric ward no .22, Acharya Vinoba Bhave rural hospital Sawangi ( Meghe) wardha on 28/9/2020 with a rare case of Wilms tumor. She is 30kg and his height is 142cm. She was admitted to the hospital, where all investigations and treatments began. She improved dramatically after therapy and continued to do so until my last day of care.
“Prognostic significance of PD-L1 Immunoexpression in Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma”: A Study Protocol
Authors: Durge Shelley , Hande Alka
Published: February 2022

Background: “Oral squamous cell carcinoma” (OSCC) is a most common type of invasive disease. It involvs damage to the oral epithelium. It gives a bad prognosis. There are alterations in cells of the oral mucosa called “oral epithelial dysplasia” (OED) and are categarised as “Oral Potentially Malignant Disorders” (OPMD). As a result, prior alteration in premalignant lesions would encourage prior cancer treatment and could essentially diminish morbidity and mortality.  “Programmed death ligand 1” (PD-L1) is functionally imputed ligand of the “co-inhibitory programmed death receptor 1 (PD-1)”. “(PD-L1)” is over-expressed on different cells including lymphocytes, tumor cells and different tissues in numerous malignancies. In this study, we will make effort to evaluate a new role of PD-L1 by correlating the immunoexpression of PD-L1 and clinicopathological characteristics and its prognostic significance in OSCC. We will evaluate and compare immunoexpression of PD-L1 in normal mucosa, OPMD and OSCC.

Methodology: Total 93 samples will be included in this study and they are divided into three groups, 31 in each group of the following: OPMD, OSCC and normal oral mucosa (control).Immunohistochemical staining will be performed and the integration of PD-L1 expression with various clinical features of OPMD and OSCC will be performed.

Expected Result: The present study will find immunohistochemical expression of “PD-L1” in OPMD and OSCC and its correlation with clinicopathological characteristics of OPMD and OSCC and 3 years disease-specific survivalof OSCC patients.

Conclusion: There is natable positive correlation of “PD-L1” appearance with OSCC. In case of OPMD, the progression of disease in terms of prognosis could be monitored. The unpredictable “PD-L1” appearance may be the main focus of integration therapy in OSCC. To provide personal immunotherapy to a variety of patients, the condition of PD-L1 should be considered.
Evaluation of Effectiveness of Platelet Rich Fibrin Matrix (PRFM) Membrane and Platelet Rich Fibrin (PRF) Membrane using Vestibular Incision Subperiosteal Tunnel Access (VISTA) Approach Technique for the Treatment of Multiple Gingival Recession Defects in Humans – A Study Protocol
Authors: Hassan Safiya , Dhadse P. V.
Published: February 2022

Background: To evaluate the effectiveness of Platelet Rich Fibrin Matrix (PRFM) membrane and Platelet Rich Fibrin (PRF) membrane using Vestibular Incision Subperiosteal Tunnel Access (VISTA) Approach method for the management of multiple gingival recession (GR) defects in humans.

Methodology: 20 subjects with gingival recession will be enrolled. 10 patient will be randomly allotted to test group (PRFM membrane) or control group (PRF membrame). Primary outcome will be gain in root coverage (RC) and secondary outcome will be Plaque index (PI), Papillary bleeding index (PBI), probing pocket depth (PPD), relative attachment level (RAL), relative gingival margin level (RGML), recession depth (RD), gingival thickness (GT) and width of keratinized gingiva (WKG). Clinical evaluation will be performed at 3 & 6 months of therapy.

Expected Results: When all the parameters will be compared at 6 months post-operatively to baseline data, both the treatment group (test and control) will be expected to show significant gain in RC, RAL gain, PPD reduction, decrease in RD, increase in GT and WKG. PRFM membrane will result in significant gain in RC, RAL gain, PPD reduction, and decrease in reduction depth, increase in GT and WKG at 6 months when compared to PRF membrane.

Conclusion: PRFM membrane will be effectual in management of gingival recession. PRFM membrane is expected to have significantly greater outcome as compared to PRF membrane group.
Overparameterized model parameter recovering with finite‐time convergence
Authors: Ovcharov Alexey , Vedyakov Alexey , Kazak Sviatolav , Pyrkin Anton
Published: February 2022

In this article, we consider the online parameter estimation problem for overparameterized linear regression models. Many estimation methods require at least the interval excitation condition, which is not always fulfilled for such models, especially in normal operation. To relax the required excitation level, we detect linearly dependent columns in the regressor, obtain the reduced model and estimate parameters in a finite time. On the last step, the parameters of the initial model are recovered. The proposed method efficiency is demonstrated on a simple overparameterized model and a magnetic levitation system.
Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
Authors: Wei Ziyu , Yi Yu , Luo Zhen , Gong Xiaoyun , Jiang Yuxing , Hou Dayong , Zhang Li , Liu Zimo , Wang Mandi , Wang Jie , Guo Ruochen , Yang Jinjun , Wang Lei , Wang Hao , Zhao Yuliang
Published: February 2022

Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural killer (NK) cells by the oxidative metabolite of the selenopeptide is developed. With the advantages of the enzyme‐induced size‐reduction and the reactive‐oxygen‐species‐driven deselenization, this selenopeptide is able to deliver therapeutics, e.g., doxorubicin (DOX), to solid tumors and further activate the NK cells in a programmed manner. Importantly, in vitro and in vivo results prove the mutual promotion between the DOX‐induced chemotherapy and the selenopeptide‐induced immunotherapy, which synergistically contribute to the improved antitumor efficacy. It is anticipated that the selenopeptide may provide a type of promising stimuli‐responsive immune modulator for versatile biomedical applications.
Enabling Stable and Nonhysteretic Oxygen Redox Capacity in Li‐Excess Na Layered Oxides
Authors: Yoon Geon‐Hee , Koo Sojung , Park Sung‐Joon , Lee Jaewoon , Koo Chanwoo , Song Seok Hyun , Jeon Tae‐Yeol , Kim Hyungsub , Bae Jong‐Seong , Moon Won‐Jin , Cho Sung‐Pyo , Kim Duho , Yu Seung‐Ho
Published: February 2022

The demands for higher energy density of rechargeable batteries have been continuously increasing recently, and cationic redox based current cathodes have little scope to further increase energy density since they already exhibit near‐theoretical specific capacities. In this regard, oxygen redox (OR) reactions have emerged as a promising breakthrough for sodium‐ion battery (SIB) cathodes. Most OR‐based layered oxides suffer from drastic hysteretic‐oxygen capacities upon discharging after the first charging. In contrast, stable and nonhysteretic oxygen capacities are herein enabled via Al3+ incorporation into Li‐excess Na layered oxide (NLMO). By combining experimental work and first‐principles calculations, it is found that there is an additional stable phase during the oxygen redox for Al incorporated NLMO in comparison with bare NLMO, which is a critical factor in extending and stabilizing the discharge capacity in thermodynamics. In addition, the additional redox‐inactive Al3+ leads to heterogeneous oxygen redox rather than homogeneous, which results in stabilization of the oxide framework with sensitively control of the oxygen participation upon cycling.
DNA‐Mediated Protein Shuttling between Coacervate‐Based Artificial Cells
Authors: Mashima Tsuyoshi , van Stevendaal Marleen H. M. E. , Cornelissens Femke R. A. , Mason Alexander F. , Rosier Bas J. H. M. , Altenburg Wiggert J. , Oohora Koji , Hirayama Shota , Hayashi Takashi , van Hest Jan C. M. , Brunsveld Luc
Published: February 2022

The regulation of protein uptake and secretion is crucial for (inter)cellular signaling. Mimicking these molecular events is essential when engineering synthetic cellular systems. A first step towards achieving this goal is obtaining control over the uptake and release of proteins from synthetic cells in response to an external trigger. Herein, we have developed an artificial cell that sequesters and releases proteinaceous cargo upon addition of a coded chemical signal: single‐stranded DNA oligos (ssDNA) were employed to independently control the localization of a set of three different ssDNA‐modified proteins. The molecular coded signal allows for multiple iterations of triggered uptake and release, regulation of the amount and rate of protein release and the sequential release of the three different proteins. This signaling concept was furthermore used to directionally transfer a protein between two artificial cell populations, providing novel directions for engineering lifelike communication pathways inside higher order (proto)cellular structures.
Exploring the Circular Polarization Capacity from Chiral Cellulose Nanocrystal Films for a Photo‐Controlled Chiral Helix of Supramolecular Polymers
Authors: Xu Mingcong , Li Guangyao , Li Wei , An Bang , Sun Jiaming , Chen Zhijun , Yu Haipeng , Li Jian , Yang Guang , Liu Shouxin
Published: February 2022

Circularly polarized light (CPL) is key to asymmetric photochemistry as it could impart the chiral organization information into chemical products. Here, we demonstrate the circular polarization capacity of chiral cellulose nanocrystal (CNC) films to trigger photo‐alignment of achiral supramolecular polymers into helical structures. Right‐handed transmitted (T‐) CPL was generated from self‐assembled CNC films, which induced amorphous azobenzene (Azo) supramolecular polymers into chiral structures. The chiral induction effect of T‐CPL is enhanced on Azo polymers with longer spacers. The absorptive dissymmetry factor (gabs) values of liquid‐crystal supramolecular polymers can be amplified significantly (over 10 times) after T‐CPL irradiation. Moreover, by integrating carbon dots into CNC films, CPL emission with a considerable luminescence dissymmetry factor (glum) up to −0.66 was achieved, and it could be used for the photo‐alignment of Azo polymers with high chiroptical properties. This work provides new insight for the photo modulation of supramolecular polymers by CPL‐active materials.