bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood Plasma Concentration of Polycyclic Aromatic Hydrocarbons in Under Five Children in Niger Delta, Nigeria
Authors:   African Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), University of Port-Harcourt, Rivers State, Nigeria., Ezebuwa Justina Ijeoma , Essien Eka B. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria, Anacletus Francis C. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria, Ikewuchi Catherine C. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria
Published: September 2023

PAHs are known carcinogens associated with immune system suppression, skin irritation, allergic reactions, respiratory problems, mutagenic issues and are generally toxic to humans. In this study, we assessed the presence and proportions of PAHs in the blood plasma of under-five children living in crude oil-polluted environment in Ogoniland, Niger Delta region of Nigeria. Communities resident in close proximity to crude oil exploration sites are constantly faced with environmental, socio-economic and health consequences of crude oil pollution. People can be exposed to PAHs through multiple routes including inhalation, ingestion and dermal contact. Ethical clearance for this study was obtained from the Ethics Committee, University of Port Harcourt. A total of 78 children were recruited from Gokana (male =17, female= 22) and Ideato (Male=15, female=24) using multi-clustered sampling method. Standard procedures were observed in this study. Results obtained were compared with under five children living in non-oil polluted environments within the Niger Delta province. The overall average PAHs was 0.331±0.383 mg/kg for Gokana males and 0.058±0.057mg/kg for Ideato males; overall average PAHs was 0.514±0.373 mg/kg for Gokana females and 0.100±0.049 mg/kg for Ideato female; overall average PAHs was 0.423±0.383 mg/kg Gokana and 0.081±0.057 mg/kg for Ideato. Under-five children in Ogoniland showed positive blood plasma PAHs higher than the comparison group in Ideato. However, carcinogenic PAHs were below levels of concern in the study population. The male gender showed higher positive PAHs than the female gender. Further studies on inflammation, stress factors and overall health status are recommended considering the vulnerability of the study population.
Blood Plasma Concentration of Heavy Metals in Under Five Children in Niger Delta, Nigeria
Authors:   African Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), University of Port-Harcourt, Rivers State, Nigeria., Ezebuwa Justina Ijeoma , Essien Eka B. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria, Anacletus Francis C. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria, Ikewuchi Catherine C. ,   Department of Biochemistry, Faculty of Science, University of Port Harcourt, East-West Road, P.M.B 5323, Port Harcourt, Rivers State, Nigeria
Published: September 2023

Environmental stressors such as pollution are major sources of heavy metal toxicity in humans. Biomonitoring studies are necessary for quantifying the body burden of these metals (As, Cd, Cr, Pb, Hg) of toxicological concern and their health effects especially for communities consistently exposed to crude oil pollution. This study investigated the level of heavy metals in the blood plasma of under-five children living in crude oil-polluted and non-crude oil-polluted environments in the Niger Delta, Nigeria. This cross-sectional study was conducted in 3 crude oil polluted communities in Gokana, Rivers State (B. Derek, K. Dere, Bomu) and 3 non-crude oil exploration communities in Ideato North LGA of Imo State (Umukegwu, Umuezeaga, Owerre-Akokwa) assigned as control; both States are in Niger Delta region of Nigeria. Ethical approval was obtained from the University of Port Harcourt Ethical Committee. A total of 78 children were recruited from Gokana (male =17, female= 22) and Ideato (Male=15, female=24) using multi-clustered sampling method. Standard methods of heavy metal analysis using atomic absorption spectrophotometer were used to analyze the samples. From the results, the concentration of Cr and Cd in the blood plasma of Gokana male was 2.81mg/kg and 3.19mg/kg while Ideato male was 0.497mg/kg of Cr and Cd was not detected. Gokana female was 1.22mg/kg for Cr and 0.92mg/kg for Cd. It was concluded that under-5 children living in crude oil-polluted communities of the Niger Delta region of Nigeria have high positive levels of heavy metals (Cr, Cd and AS). Health effect of the exposures is advised considering the sensitivity of the study population
Modelo para la selección de lanzadores de béisbol empleando el Proceso Analítico Jerárquico a través de la evaluación de su desempeño integral
Authors: Teppa-Garran Pedro , Fernández-Da Costa Carlos
Published: September 2023

El Proceso Analítico Jerárquico es una herramienta matemática, ampliamente usada en la toma de decisiones, destinada a la detección de una jerarquía global en un conjunto cuyos elementos se conocen relaciones de prioridad dos a dos. La evaluación de lanzadores de béisbol es una componente estratégica fundamental del desempeño de los equipos, la cual se puede plantear en términos de un problema de toma de decisiones multicriterio. En este trabajo se elaboran modelos para clasificar el desempeño de lanzadores de béisbol en la MLB en los roles de abridor y relevista haciendo uso del Proceso Analítico Jerárquico. Los modelos permiten evaluar el desempeño integral del lanzador. Los modelos fueron aplicados en la evaluación de abridores para el premio Cy Young de la temporada 2021 y en la evaluación de relevistas para los premios Trevor Hoffman y Mariano Rivero en la temporada 2017. Igualmente, los modelos permitieron evaluar la trayectoria de un conjunto de abridores emblemáticos venezolanos que realizaron su carrera en la MLB. Los resultados obtenidos fueron satisfactorios y confirman la eficiencia y factibilidad de los modelos propuestos.
"O Ornitorrinco", 20 anos depois
Authors: José Araújo dos Santos Fabiano
Published: September 2023

O presente trabalho resgata a crítica presente em “O ornitorrinco”, famoso ensaio da última fase da produção teórica do sociólogo marxista Francisco de Oliveira, em que se discute a estrutura da economia brasileira no início deste século, caracterizando-a como um “impasse evolutivo”, à semelhança do animal que dá título ao ensaio. Tendo vindo à luz em um momento de grande euforia pela chegada de Luiz Inácio Lula da Silva à Presidência em seu primeiro mandato, o texto, na contramão disso, confirma Oliveira como um dos poucos críticos ferrenhos do novo governo em sua etapa inicial. Com efeito, ao identificar, muito cedo, o projeto do governo petista como sendo de continuidade em relação a seu antecessor, FHC, entendia-o tanto como um golpe nas esperanças de transformação social quanto como uma grande oportunidade desperdiçada. Tratava-se, para ele, portanto, de um projeto político que confirmaria o país no limbo histórico entre o que então havia de “mais primitivo” e “mais avançado”, funcionando num todo complexo e orgânico unicamente para confirmar e aprofundar o que a sociedade capitalista brasileira historicamente produzira de mais brutal. O breve texto que se segue busca, então, fazer um pequeno balanço (não exaustivo) da análise de Oliveira em diálogo com alguns pontos que buscam caracterizar a realidade do país exatos 20 anos depois, no momento em que Lula inicia seu terceiro mandato como presidente.
Temperature measurements in the air gap of highly insulated wood-frame walls in a Zero Emission Building
Authors:   SINTEF, Brozovsky Johannes , Oksavik Odne ,   SINTEF, Rüther Petra ,   SINTEF
Published: September 2023

Especially for wooden wall constructions, ventilated rain-screen walls have been used for many decades to prohibit moisture-induced damage. The air gap behind the façade cladding provides drainage, enhances ventilation, and thus facilitates drying of wetted façade components. The conditions in the air gap behind different cladding materials, however, are still an object of research. In the presented study, the interim findings after more than two years of ongoing measurements in the air gap behind different cladding materials of a zero-emission office building in the high-latitude city of Trondheim, Norway are presented. The results provide valuable insight into the temperature conditions in the air gap of ventilated claddings in order to determine the in-use conditions of building materials and develop improved testing schemes. The results indicate that the air and surface temperature in the air cavity of the walls is strongly influenced by the solar radiation incidence on the facades. Both the highest and lowest values were observed on the roof with 81 °C and -21.9 °C, respectively, at the back side of the building integrated photovoltaic modules, resulting in a total temperature range of almost 103 °C.
THE ISLAMIC COMMUNAL LANDS IJMA: IN THE CASE OF MEDIEVAL AND EARLY MODERN AZERBAIJAN
Authors: Shabiyev Beymirze
Published: September 2023

Land properties and the legal regimes that they are subject, provide important data on the legal, social, economic and military aspects of a given country and characterize its economic features. In the countries of the Middle East, the system of land tenure, based on Sharia Law, was formed during the period of the Arab Caliphate and, with minor changes, lasted for centuries. The aim of this paper is to examine the main essence of the Islamic communal land property- arazî-i ijma or arazî-i āmma in the medieval and early modern Azerbaijan, based on the several documents of the title-deed - qabale. This research proposes a concept that being land in the public benefits, arazî-i ijma was one of the forms of private ownership- mulk lands.
Factors Affecting Decisions Not to Engage in Premarital Sex Among Maritime First-Year Students in Cebu, Philippines
Authors: Romagos Allan P , Sagayno Renato C , Geraldizo Jr Benjamin P , Echavez Ronnel R , Alquilita Sean Xavier O
Published: September 2023

Premarital sex can be both fulfilling and detrimental to college students. Studies were conducted on the factors that induced premarital sex among college students. However, no study has been conducted yet, regarding maritime students-based factors affecting premarital sex decisions in the Philippines. The objective of this study is to provide the general public, especially the student-readers, an idea of the extent of the factors affecting decisions not to engage in premarital sex among maritime first-year students in Cebu, Philippines. Three hundred sixty maritime first-year students were selected from the University of Cebu maritime department of S.Y. 2020-2021. A descriptive-quantitative method of research without experimentation was utilized. Systematic random sampling was used to establish the sample size. A modified survey questionnaire adopted from the study was used as the main instrument. Percentages and frequency counts were used to calculate and interpret the data. Results revealed that most respondents were not involved in premarital sexual activities. The major factors affecting their decisions not to engage in premarital sex are family values, followed by religious doctrines. The results of the study will also enrich literature in as much as it will give numbers and facts as bases to the Philippine Commission for Higher Education, college institutions, and ethics teachers in the Philippines to promote the use of books and the creation of teaching materials that tackle more lessons on sexuality, family and religious values to reinforce the Filipino maritime students for the present and future moral challenges.
The effect of preoperative fasting time on physiological parameters in patients undergoing thyroid surgery
Authors: Aslantas Ceren , Tuna Arzu
Published: September 2023

The research was conducted between January 2022 and June 2022 in the Department of Surgery, Inonu University, Turkey. The sample of the study consisted of 40 consecutive patients who underwent thyroidectomy surgery. After obtaining the necessary permissions from the ethics committee, patients, and the chief physician of the medical faculty hospital, the research was conducted. Research data were collected using the patient diagnosis form, the form for assessing patients; vital signs, the form in which the laboratory values of the patients are determined, and the wound site evaluation form of patients three days after surgery. As a result of the research, it was determined that heart rate, body temperature, and HbA1c value may be affected as the fasting period gets longer. In surgeries performed in other patient groups and in patients with a higher population of thyroid surgery, it was suggested that new research should be done to examine the effect of fasting duration on vital signs, wound site, and blood laboratory values.
Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas
Authors: Kiran Merve , Sungu Nuran , Dogan Hayriye , Ardicoglu Arslan , Erdogan Fazli , Gumuskaya Berrak
Published: September 2023

Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing "high" or "low" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.
The relationship of depression and malnutrition with healthy eating index in elderly individuals
Authors: Alatas Hacer , Arslan Nurgul , Aytas Ozgur
Published: September 2023

Depression, malnutrition, and the healthy eating index were assessed in this study of people aged 65 and up who sought treatment at an outpatient clinic for internal medicine. Participants were elderly people from Malatya, Türkiye, who had applied to the outpatient clinic for internal medicine. The three-day dietary recall method was used to obtain the records of food consumption among the elderly. The calculation of Healthy Eating Index-2015 (HEI-2015) scores from food consumption. Geriatric Depression Scale (GDS) was used to define probable depression, and Mini Nutrition Questionnaire-Short Form (MNA-SF) was used to determine nutritional status, using face-to-face interviews. The study were 185 individuals included. The mean age of individuals was 72.19±6.92 years. According to MNA-SF results, 32.3% of women and 27.4% of men were found to be malnourished. The mean body mass index (BMI) value of the individuals was 25.73±2.85 kg/cm2, and the BMI value of 56.22% of the individuals was within the normal range. The depression score mean was 8.86±4.73. Depression scores are higher in women, those with low monthly education and income, those who use multiple drugs, those with a low HEI-2015 score, and those who use them. There is a relationship between depression score and eating score. As the nutrition score and the HEI-2015 score decrease, the depression score increases. This study indicates that depressed older people consume less food. Early detection of depression and malnutrition is beneficial. Older adults should routinely use brief, easy-to-obtain diagnostic tools such as the MNA and GDS questionnaires to treat these related health issues quickly and effectively.
Comparative efficacy of 1% terbinafine hydrochloride cream and 1% ciclopirox olamine cream alone and in combination for the treatment of dermatophytosis
Authors: Chhabra Karan , Mitra Yash , Bassan Rattan
Published: September 2023

Background: Various antifungal agents, both in oral and topical forms, have been developed for the treatment of dermatophytosis.

Aims and Objectives: The aims of this study were to evaluate the efficacy of 1% terbinafine hydrochloride cream and 1% ciclopirox olamine cream alone and in combination in the treatment of dermatophytosis.

Materials and Methods: A randomized and comparative study was done at the Department of Dermatology, Government Medical College and Hospital, Chandigarh. Sixty patients of clinically diagnosed tinea corporis/tinea cruris/tinea faciei, attending the outpatient department will be allocated to three therapeutic groups of 20 patients each using random tables. Group 1: Topical 1% terbinafine hydrochloride cream twice daily for 6 weeks. Group 2: Topical 1% ciclopirox olamine cream twice daily for 6 weeks. Group 3: Topical 1% terbinafine hydrochloride cream once daily in the morning and 1% ciclopirox olamine cream once daily in the evening for 6 weeks. Inclusion criteria: (i) Body Surface Area – <10%, not requiring systemic therapy. Exclusion criteria: (i) Patients with coexisting dermatophytosis, any antifungal drugs, or pregnant, and lactating women. All the patients were assessed for therapeutic results by clinical evaluation at 3 and 6 weeks of initiation of therapy. Approved by Ethics Committee. Data collected on a pre-tested structured questionnaire and analyzed by Statistical Package for the Social Sciences.

Results: After 6 weeks of treatment in Group 2, there was no erythema in 1 (6.7%) patient, moderate in 2 (13.3%) patients, mild in 12 (80%) patients, and no severity in any patient. After 6 weeks of treatment in Group 1, erythema was mild in 17 (45%) patients. After 6 weeks of treatment in Group 3, erythema was moderate in 1 (5.3%) patients, mild in 15 (78.9%) patients, and three patients had no erythema. None of the patient had severe erythema. P = 0.209 and Chi-square was 5.875.

Conclusion: The combination therapy with both terbinafine hydrochloride and ciclopirox olamine group showed better response with lesser relapse rate with no significant side effects.
Study of antitubercular drugs on liver function tests in newly diagnosed tuberculosis
Authors: N Anitha , Dasari Raju , Cherlopalli Suresh , Sriram Sujana
Published: September 2023

Background: Particularly in areas where both tuberculosis and liver illness are prominent, it is necessary to determine the factors that put patients at risk for developing anti-tuberculosis drug-induced hepatotoxicity (anti-TB-DIH). In this study, both the prevalence of anti-TB-DIH and the factors that contribute to its development were studied. As a consequence of this, the purpose of the present study was to explore the abnormal liver function test in patients who were being treated for tuberculosis.

Aims and Objectives: (i) To investigate hepatotoxicity in antitubercular patients. (ii) To protect the liver from chemotherapy drug side effects through early detection. (iii) To understand drug-induced hepatotoxicity risk factors.

Materials and Methods: This is a prospective study of one hundred patients who were treated at the Department of Pulmonary Medicine and the Department of Pharmacology at the Rajiv Gandhi Institute of Medical Sciences in Kadapa between January 2022 and January 2023.

Results: Patients varying in age from 15 to 30 years comprised 21 (21%) of the study, 31–50 years comprised 31% of the study, 51–70 years comprised 38% of the study, and 71–80 years comprised 10% of the study, with 68 (68%) males and 32 (32%) females. When compared to the levels that were present before therapy, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) exhibited a substantial increase after 2 months of treatment. A comparison of the patient’s levels of AST, ALT, ALP, and gammaglutamyl transpeptidase (GGT) before treatment and after treatment for 6 months demonstrated a considerable rise in all of these enzymes’ activities.

Conclusion: Because it was established that the majority of patients suffer hepatotoxicity within the first 14 days of beginning antituberculosis therapy (ATT) medication, it is imperative that the liver function of patients be monitored in the initial days in which treatment with ATT is being initiated.
Comparison of coronary arteries morphometry and distribution in bovines with humans and other animal species
Authors: Torres Fabi , Machado Luz , a Luis
Published: September 2023

Background:
The left coronary artery in the bovines is more developed than the right.
Aim:
The objective of the study is to describe the bovine coronary system from a morphological point of view, including the morphometry and its distribution.
Methods:
Arciform suture with 2.0 silk was applied around the sinus orifice and coronary ostium and a number 14 catheter was installed, to perfuse semi-synthetic polyester resin, consisting of a mixture of 85% GP40L palatal with 15% styrene with red color mineral.
Results:
The average weight of 28 bovine hearts used in our study was 1.534.1 kg. The right coronary artery had a proximal caliber of 5 +/- 0.9 mm. The left coronary artery caliber and length were 9.4 +/- 1.2 mm and 18.3 +/- 4.8 mm, respectively. This artery was divided into two branches in 85.7% of the cases and trifurcated in 14.3%. The paraconal interventricular branch ended more frequently in the apex (46.4%), and its proximal caliber was 6.4 +/- 1.4 mm. The left circumflex branch ended in 82.1% in the subsinusal interventricular sulcus, and its proximal caliber was 5.9 +/- 1.2 mm. The proximal calibers of the paraconal interventricular branch and the left circumflex branch did not present statistically significant differences (p=0.137). The sinoatrial branch presented a dual origin (right and left coronary arteries) in 46.4% of the cases and a single origin from the left coronary artery in 53.6% of the samples. In the evaluated hearts, left coronary dominance was observed in most cases (96.4%). There presence of anastomosis between the branches of the coronary arteries was observed in 57.1% of cases.
Conclusion:
The presence of a myocardial bridge was found in six hearts (21.4%). In bovines, a high percentage of anastomosis was found, a protective factor in obstruction of the coronary arterial branches.
Echocardiographic values in healthy Pugs: Effect of body weight, age, and sex
Authors: Romito Giovanni , Castagna Prisca , Sabetti Maria , Ablondi Michela , Cipone Mario
Published: September 2023

Background:
Transthoracic echocardiography represents the main noninvasive technique for evaluating cardiac morphology and function in dogs. In dogs with particular somatotypes, such as brachymorphic dogs, breed-specific echocardiographic values are needed for a proper echocardiographic interpretation. Nowadays, the Pug represents one of the most popular brachymorphic canine breeds worldwide. However, data on echocardiographic measurements in this breed are currently limited.
Aim:
We aimed to determine echocardiographic values in a population of apparently healthy Pugs, and to assess the possible effects of body weight, age, and sex on selected echocardiographic variables, with particular emphasis on those related to the left-sided cardiac chambers.
Methods:
Apparently healthy Pugs underwent a full physical examination, a one-minute six-lead electrocardiogram, and a complete transthoracic echocardiography. Twenty-four echocardiographic variables were measured combining M-mode, two-dimensional and Doppler modalities, and relative values were determined by applying the statistical procedures recommended by the Clinical and Laboratory Standards Institute. Moreover, the effect of selected demographic variables on echocardiographic measurements were tested using a linear mixed model.
Results:
The investigation included 86 Pugs. Echocardiographic values were provided for each variable and compared with previous veterinary literature. A statistically significant effect of body weight (e.g., end-systolic left ventricular diameter and absolute left atrial diameter), age, and sex was documented for several of the tested variables. Doppler examination demonstrated a trivial pulmonary regurgitation in 24/86 (27.9%) Pugs. Moreover, a persistent left cranial vena cava was suspected in 4/86 (4.7%) dogs.
Conclusion:
Echocardiographic features of the Pug were addressed and echocardiographic values made available for clinical use. Because our findings were obtained using a standardized echocardiographic analysis in a population of 86 healthy Pugs, they may act as a reliable guide for an accurate echocardiographic interpretation in this breed.
Evaluation of renal disturbance in animal models of polycystic ovary syndrome
Authors: Oktanella Yudit , Untari Handayu , Wuragil Dyah , Agustina Galuh , Pratama Dyah
Published: September 2023

Background:
Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism, hyperinsulinemia, followed by luteinizing hormone (LH) and follicle stimulating hormone (FSH) deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde levels. Animal models of PCOS have been used extensively in research to study the pathogenesis, clinical characteristics and treatment of PCOS.
Aim:
This study aimed to identify the pathological mechanisms underlying renal dysfunction in PCOS by observing several parameters, including BUN, creatinine, uric acid, and renal MDA levels.
Methods:
This research was an experimental designed study using Wistar rat (Rattus norvegicus) as animal model of PCOS which were divided into three groups: negative control (CN) group (n=6), Testosterone propionate induction group (n=6), and estradiol valerate induction group (n=6).
Results:
According to statistical analysis it indicated that induction of TP and EV can increase blood uric acid levels in PCOS model rats (p<0.05), TP induction can increase kidney BUN and MDA levels significantly (p<0.05), However, the observation of creatinine levels did not show significant differences in all treatment groups (p>0.05).
Conclusion:
Based on the results of this study, it can be concluded that the induction of animal models with testosterone propionate can trigger a significant renal damage compared to estradiol valerate.
Dermatologic adverse effect of subcutaneous furosemide administration in a cat
Authors: Mazzoldi Chiara , Aspidi Francesca , Romito Giovanni
Published: September 2023

Background:
Furosemide is a mainstay of treatment in congestive heart failure (CHF) and is widely prescribed to dogs and cats by several formulations, including the subcutaneous one. In canine and human medicine, dermatologic adverse effects to subcutaneous furosemide (SF) have been documented; conversely, no prior case has been published describing skin reactions to this therapeutic protocol in cats. In this report, we describe, for the first time in feline medicine, a suspected dermatologic adverse effect after SF in a cat.
Case Description:
A 2-year-old domestic shorthair cat was presented for CHF associated with lung edema and pleural effusion. Echocardiography revealed asymmetric left ventricular myocardial thickening and severe left atrial dilation. The cat was hospitalized and initially treated with oxygen, intravenous furosemide and clopidogrel. After discharge, the route of administration of furosemide was switched from intravenous to oral. Within the following 2 weeks, the cat experienced two relapses of lung edema despite the progressive increase of furosemide dose, the addition of spironolactone and adherence to the therapeutic protocol by the owners. The dose of furosemide was further increased and its route of administration at home was switch from oral to parental. As the owner were not able to administrate intramuscular injections, SF was prescribed. This allowed preventing further episodes of lung edema. However, although the cat had never presented skin problems before, multiple well-defined circular, crusted ulcerative cutaneous lesions associated with alopecia developed at the sites of furosemide injections 2 weeks later. After ruling out several differential diagnoses for these lesions, a rare side effect to furosemide, not yet described in cats but already known in canine and human medicine, was strongly suspected as the possible cause. Therefore, the ongoing injectable formulation of furosemide was interrupted and substitute that with an alternative brand, maintaining the same dose and route of administration. Thanks to this change, the dermal ulcerations disappeared within 1 month. Subsequently, the cat experienced neither further skin problems nor recurrence of lung edema.
Conclusion:
Although SF is sometimes prescribed in small animal practice, it should be noticed that this may lead to dermatologic adverse reactions in the cat.
Data breach and privacy in the digital era
Authors:   eProcess International, Ecobank Transnational, Accra, Ghana, Oghene Augustine
Published: September 2023

The trend of data breaches globally is attracting concerns from business owners and the government of different countries. Notwithstanding the multiple pieces of legislation and strict requirements for reducing crime, there has been an exponential increase in data breach incidents. These crimes result in the loss of billions of dollars annually from small entities and large enterprises. Data breaches did not only start during the digital era with technological advancement; they started when individuals and organizations stored and maintained their data and records on-premises. However, as technology advances and computer systems become more accessible and affordable, coupled with poor management of sensitive documents, data breaches occur when individuals view other people’s files without authorization. The rate of data breaches rose from 1980 to the early 2000s, giving rise to awareness of the canker. Laws and regulatory agencies such as Health Insurance Portability and Accountability Act (HIPAA)and Payment Card Industry (PCI) Data Security Standards were then established to guide sensitive data and the custodians. Regulatory frameworks developed as best practices to secure sensitive information are, however, not being implemented exhaustively, thereby not able to gatekeep satisfactorily. Data breach frequency is high in the digital era. The digital era exposes organizations and individuals continually to potential security breaches. Technologies like artificial Intelligence, machine learning, and data modeling make it possible to design algorithms and neural networks that help anticipate events and generate more data. Subsequently, fling open the gates to potential data breaches. In essence, it becomes absolutely necessary to consider the aftermath of information security and privacy in this digital era.
Reconnoitering advantages and challenges of integrating physical education into the curriculum
Authors: Sharma Dr. Lok Raj , Upreti Uttam
Published: September 2023

Physical education (PE) is an academic subject that aims to promote physical fitness, healthy lifestyle habits, and overall well-being through physical activity and exercise. It emphasizes the development and maintenance of physical fitness and skills through sports, exercise, and games. Curriculum is a structured framework that facilitates learners in accomplishing specific learning goals and objectives, encompassing planned activities, materials, assessments, topics, skills, methods of instruction, and expected outcomes. The primary aim of this article is to reconnoiter the advantages and challenges of integrating PE into the curriculum. Secondary qualitative data, extracted from relevant books and journal articles, have been collected to support the study. The article concludes that incorporating PE into the curriculum significantly contributes to students' holistic development. PE imparts students with a profound understanding of the significance of regular physical exercise in reducing the risk of obesity, diabetes, cardiovascular disease, stress, anxiety, and depression. Furthermore, PE has the potential to enhance academic performance by improving concentration, memory, and creativity. This article plays a crucial role in advocating for equal importance to be given to PE alongside other subjects in the curriculum, both by inspiring students and guiding curriculum designers.
Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis, and Bordetella bronchiseptica isolated from pigs in the United States and Canada, 2011 to 2015
Authors: Sweeney Michael , Lindeman Cynthia , Johansen Lacie , Mullins Lisa , Murray Robert , Senn Michael , Bade Donald , Machin Chandra , Kotarski Susan , Tiwari Raksha , Watts Jeffrey
Published: September 2023

Objective: To report the susceptibility to veterinary antimicrobial agents of Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis, and Bordetella bronchiseptica isolated from pigs in the United States and Canada from 2011 to 2015. Materials and methods: In vitro broth microdilution susceptibility testing for minimal inhibitory concentration values were performed using 10 antimicrobial agents (ampicillin, ceftiofur, danofloxacin, enrofloxacin, florfenicol, penicillin, tetracycline, tilmicosin, trimethoprim-sulfamethoxazole, and tulathromycin) with Actinobacillu pleuropneumoniae (n = 312), P multocida (n = 855), S suis (n = 1201), and B bronchiseptica (n = 572) following methods and susceptibility breakpoints approved by the Clinical and Laboratory Standards Institute. Results: Actinobacillu pleuropneumoniae isolates were 100% susceptible to ceftiofur and florfenicol, and P multocida isolates were 100% susceptible to ceftiofur, enrofloxacin, and florfenicol. High rates of susceptibility (90% to > 99% susceptible) were observed for A pleuropneumoniae to enrofloxacin and tulathromycin, for P multocida to ampicillin, penicillin, tilmicosin, and tulathromycin, for S suis to ampicillin, ceftiofur, and florfenicol, and for B bronchiseptica to tulathromycin. Tetracycline exhibited low susceptibility rates against A pleuropneumoniae (0% to 6% susceptibility), P multocida (22.3% to 35.3%), and S suis (0% to 1.3%). No susceptibility of B bronchiseptica to ampicillin (0%) and low rates of susceptibility to florfenicol (5.4% to 23.5%) were also observed. Implications: Under the conditions of this study, high rates of susceptibility to most veterinary antimicrobial agents continue to be seen for A pleuropneumoniae, P multocida, S suis, and B bronchiseptica, the predominant pathogens associated with swine respiratory disease in the United States and Canada.
BeTTer Outcomes Workgroup Health Quality Initiative to optimize bone health for prostate cancer patients in the British Columbia Cancer System
Authors: Noonan Krista , Ko Jenny J. , Black Peter C. , Peacock Michael , Finch Daygen , Kollmannsberger Christian , Martins Ilidio , So Alan I. , Pai Howard H.
Published: September 2023

Introduction: Bone-targeted therapies (BTTs) are integral to the management of bone metastases in metastatic castration-resistant prostate cancer (mCRPC). BTTs vary considerably in referral and drug access pathways and optimal BTT use requires multi-specialty consultation and supervision. Health quality improvement (HQI) has become the predominant framework to improve patient care in multidisciplinary settings.
Methods: HQI initiatives on use of BTT in mCRPC were developed and evaluated in five centers of a provincial cancer center network using Plan-Do-Study-Act (PDSA) methodology. Multidisciplinary teams (MDTs) completed a common quality assessment form and an HQI template and then implemented an HQI initiative. Feedback and findings were shared and discussed at regional events. It was subsequently determined whether to adopt, adapt, or abandon initiatives.
Results: Patterns of unmet needs varied across type of BTT. Gaps in use of radium-223 were mostly referral and education issues that could be directly addressed at the local level by participating clinician teams. Conversely, most supportive BTT gaps were related to coverage and resourcing support. HQI initiatives selected by each site consisted of implementation or expansion of local MDT meetings, referral documents, databases, and improvement charters. The main HQI initiative was completed in four sites and was adapted or adopted in three. Improvements in BTT use were observed in two of three centers with data on HQI process measures.
Conclusions: Despite the overall heterogenous structure of the groups and metrics used, this study demonstrated that the PDSA framework provides the needed structure for improvements in BTT use in mCRPC across multiple sites.
Дивідендна політика в стратегічному управлінні ринковою капіталізацією корпоративних аграрних підприємств
Authors: Сусліков А. О.
Published: September 2023

Актуальність досліджень полягає в тому, що дивідендна політика виконує важливі завдання стратегічного розвитку корпоративного аграрного підприємства, є механізмом перерозподілу фінансових ресурсів усередині компанії та чинником інвестиційної привабливості на фондових ринках. Метою статті є поглиблення досліджень засад дивідендної політики в стратегічному управлінні ринковою капіталізацією корпоративних аграрних підприємств. У процесі дослідження було використано такі методи: монографічний, абстрактно-логічний, аналізу й синтезу, історичного й системного аналізу, узагальнення графування. Досліджено теоретико-методичні засади дивідендної політики в стратегічному управлінні ринковою капіталізацією корпоративних аграрних підприємств. Показано, що дивідендна політика істотно впливає на інвестиційну привабливість агрокомпанії на фондових ринках, певною мірою визначаючи ціну акції й ринкову капіталізацію. Обґрунтовано, що дивідендна політика корпоративних аграрних підприємств має здійснюватися на основі принципів стабільності, регулярності й планомірності виплат дивідендів, збереження ліквідності та врахування потреб капіталу для росту компанії. Встановлено, що основними функціями дивідендної політики корпоративних аграрних підприємств є сигнальна (інформаційна) функція, розподільча функція, стимулююча функція, організаційна функція, функція збереження ліквідності, функція збалансованості фінансової структури, функція регулювання внутрішнього фінансування. Теоретично показано вектор впливу на ринкову капіталізацію агропідприємства типу дивідендної політики й підходів до дивідендних виплат. Запропоновано стратегічне забезпечення дивідендної політики корпоративних аграрних підприємств. Показано, що основою ефективної дивідендної стратегії корпоративних аграрних підприємств є розвиток національного фондового ринку, трансформація й адаптація найефективніших моделей корпоративного управління, а також нормативне й інституціональне забезпечення дивідендної політики. Перспективами подальших розвідок є обґрунтування методичних засад оцінювання ефективності реалізації дивідендних політики корпоративних аграрних підприємств з урахуванням інвестиційних і фінансових ризиків їх капіталізації на фондових ринках.
The Influence of Environmental, Social, Governance on Company Financial Risks: A Study on LQ-45
Authors: Ramadhan Muhammad Farhan , Achsani Noer Azam , Andati Trias
Published: September 2023

This study aims to see the consequence of environmental, social, and governance (ESG) performance on LQ-45firm’s financial risk. This study uses a 23 sample of LQ-45 firms from 2016 to 2020 and applies Generalized Method of Moment (GMM) analysis. The studies find an adverse effect of ESG Performance and firm’s risk. Controversies on ESG also adversely influences the firm’s risk. However, there is no significant effect on board gender diversity on financial risk of the firm. Also, These findings are in line with stakeholder, signaling, Legitimacy, and risk management theory. The firms that perform reasonably on ESG have lower total risk. However, the firm’s negligence on ESG and involvement in ESG Controversies moderates the ESG-total risk nexus. The findings will help investor and portofolio managers evaluate how ESG, ESG Controversies, and Board Gender Diversity influence firm’s financial risk and help them make a better investment decisions. Additionally, regulators can revise the ESG and ESG Controversy disclosure criteria and make them accessable to all stakeholders for better decision making.
Pengaruh Pembelajaran Daring Terhadap Hasil Belajar Mata Kuliah Producing Pada Sekolah Tinggi Multi Media Yogyakarta
Authors: Sugiyo Sugiyo
Published: September 2023

Latar Belakang: Pembelajaran klasikal yang dilakukan melalui tatap muka, bertemu dalam kelas, ada interaksi langsung antara mahasiswa dan dosen saat ini berubah.

 

Tujuan: bertujuan menjelaskan pengaruh pembelajaran daring terhadap hasil pembelajaran mata kuliah producing pada Sekolah Tinggi Multi Media. Variabel bebas berupa pembelajaran daring perlu mendapatkan perhatian dalam kegiatan pembelajaran saat terjadi covid 19.

 

Metode: Penelitian ini berjenis kuantitatif bersifat ekplanasi dan metode penelitiannya adalah survey.

 

Hasil: hasil pembelajaran. Penelitian ini dirancang dengan menggunakan pendekatan kuantitatif, pengumpulan data menggunakan kuesioner atau angket dan alat analisis yang digunakan adalah kuantitatif berupa regresi linear berganda dengan sampel sebanyak 97 mahasiswa pada STMM Yogyakarta.
Pengelolaan Kepariwisataan Di Masa Pemulihan Pandemi Covid-19 (Studi Kasus Pariwisata Danau Toba)
Authors: Yunita Dina
Published: September 2023

Latar Belakang: Pandemi Covid-19 menyebabkan kunjungan wisatawan menuju danau toba turun hingga 99,92% hampir tidak ada yang berkunjung diawal diumumkannya pandemi. Keadaan ini membuat banyak pengusaha pariwisata di daerah danau toba mengalami kerugian dan masyarakat yang menggantungkan hidup dari pariwisata danau toba mengalami kesulitan ekonomi yang cukup hebat.

 

Tujuan: bertujuan untuk mendapatkan pengelolaan kepariwisataan danau toba dalam hal pemulihan ekonomi, strategi pemulihan pemasaran dan promosi serta penguatan kelembagaan berdasarkan Analisis kebutuhan.

 

Metode: Metode Survei dengan Teknik wawancara dapat dilaksanakan melalui wawancara tatap muka, focus grup interview, wawancara melalui telepon ataupun wawancara melalui koneksi internet.

 

Hasil: hasil analisa tersebut belum terdapat kolaborasi yang baik, sehingga untuk mencapai kolaborasi yang baik antar pengelola dapat Membuat Perencanaan Pemulihan ekonomi berdasarkan Analisa Dampak covid-19 terhadap pelaku parwisata danau toba, perencanaan dibuat oleh multi-pemangku kepentingan yang saling berkolaborasi dan mempertimbangkan kebutuhan masing-masing.
Analisis Faktor-Faktor Yang Mempengaruhi Permintaan Asuransi Pendidikan Pada Pt Prudential Puraini Medan
Authors: Susanti Harahap Marni Susi , Syahriza Rahmi
Published: September 2023

Asuransi pendidikan merupakan produk gabungan antara asuransi jiwa ditambah dengan instrumen pasar uang. Asuransi akan menjamin biaya pendidikan anak bila nanti orang tuanya tidak dapat lagi mencari nafkah karena meninggal dunia, atau cacat total. Berdasarkan hal tersebut, peneliti terdorong untuk mecoba menggambarkan dan menjelaskan pengaruh permintaan asuransi pendidikan pada PT Prudential Pruaini Cabang Kota Medan. Jenis penelitian ini adalah deskriptif kuantitatif dimana peneliti melakukan sendiri pengamatan atau wacana dengan struktur organisasi dengan menggunakan buku catatan. Hasil penelitian menunjukkan adanya faktor-faktor yang mempengaruhi permintaan asuransi pendidikan pada PT Prudential Pruaini Cabang Kota Medan. Adapun faktor-faktor yang mempengaruhi permintaan asuransi pendidikan pada PT Prudential Pruaini  Cabang Kota Medan tersebut adalah faktor Pendapatan faktor Usia.
SHARIAH ANALYSIS OF E-COMMERCE TRANSACTIONS FROM THE PERSPECTIVE OF ISLAMIC ECONOMICS
Authors: Hayati Suci , Fatarib Husnul
Published: September 2023

Background: Technological developments have had an impact on changes in daily living habits, people who used to shop at traditional markets are now switching to e-commerce because they are considered more effective, efficient and also cheaper. The impact of technological developments extends to Indonesia. This is marked by the proliferation of e-commerce businesses.
Objective: The aim is to find out the security and shariah of e-commerce transactions in the perspective of Islamic economics. Therefore, researchers are interested in conducting research with the title "Analysis of the Security and Sharia of E-Commerce Transactions in the Islamic Economic Perspective".
Methods: Qualitative research method is a research method based on the philosophy of postpositivism, used to examine the condition of natural objects, (as opposed to experiments) where the researcher is the key instrument, data collection techniques are carried out by triangulation (combined), data analysis is inductive/qualitative , and the results of qualitative research emphasize the meaning of generalization (Sugiyono, 2014).
Results: The results of the study show that sharia e-commerce transactions in a sharia economic perspective are the same as buying and selling transactions, which are required to have at least 4 things that must be fulfilled; namely the buyer, the seller, the medium of exchange (money), and the goods being traded or the object of the transaction.
Conslusion: Technological developments have had an impact on changes in daily living habits, people who used to shop at traditional markets are now switching to e-commerce because they are considered more effective, efficient and also cheaper. The impact of technological developments extends to Indonesia. This is marked by the proliferation of e-commerce businesses.