bluuebunny/crossref_metadata_2025 huggingface dataset:
On the state of public health and healthcare Siberian Federal District during the pandemic (some results of 2020)
Authors: Chernyshev V. M. , Voevoda M. I. , Strelchenko O. V. , Shalygina L. S. , Mingazov I. F.
Published: February 2022

Introduction. The COVID-19 pandemic has become a huge challenge for the entire healthcare system, medical institutions and doctors. The results of the industry’s activities turned out to be insufficiently effective, and therefore it is necessary to analyze not only what is directly related to the coronavirus infection, but also the consequences that the pandemic has led to. Goal. To analyze the results and consequences of health care activities and the health status of the population of the Siberian Federal District during the COVID-19 pandemic. Material and methods. The statistical data of the Ministry of Health of the Russian Federation, Rosstat, the Central Research Institute for the Organization and Informatization of Healthcare (TSNIIOIS), the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, as well as data for the Siberian Federal District were used. Scientific publications on the problem under consideration have been studied. Results and discussion. In connection with the beginning of the COVID-19 pandemic in Russia, as in all countries of the world, serious anti-epidemic measures were carried out, the procedure for providing medical care to the population changed, the consequences of which did not have the best effect on their health, including in the Siberian Federal District. The number of visits per resident of the district as a whole decreased by 16.2 %, in the polyclinic by 19.5 %, at home increased by 44.4 %. The number of visits for preventive purposes decreased by 6 %, and the coverage of dispensary observation by 11.2 %. The proportion of patients with oncological diseases in stages 3-4 increased to 40.6 %. Hospitalization of the SFO declined by 17.2 %, the number of operated patients 17.8 %, and postoperative complications have increased by 43.7 % from 1.07 to 1.54 %. Total mortality amounted to in 2020 for 14.5 per 1,000 population, i.e. increased by 18 % compared to 2019 year, while only 1/3 was due to COVID-19. In 2020, the number of Russians decreased by 510 thousand people. Conclusions. The results of health care activities, a significant deterioration in the health of the population and the complication of the demographic situation in the country during the pandemic, indicate serious shortcomings in the organization of medical care to the population, primarily in extreme situations, and requires a deep analysis and adequate measures to improve the structure and functioning of the industry in any conditions.
Uso de digestores anaeróbicos de pequeña escala como solución ambiental y energética
Authors: Machado Letícia Ribeiro , Ferrarez Adriano Henrique , Zelaya-Benavidez Edwin Alfonso , Junior Jader Lugon , Alves Fernando César
Published: February 2022

La energía juega un papel central en el desarrollo de la sociedad y la búsqueda de fuentes renovables y sostenibles aumenta cada día. La digestión anaeróbica és una tecnología que permiten producir energía limpia a partir de residuos orgánicos mejorando la calidad medio ambiental y de vida de la población. El objetivo de este trabajo fue evaluar la publicación de artículos científicos sobre digestión anaeróbica a pequeña escala. Se realizó una búsqueda de trabajos científicos en bases de datos como Scielo, Scopus, Science Direct y Google Scholar, con base en las palabras clave: small scale anaerobic digestion, biogas, small scale biodigestor, small scale anaerobic codigestion e renewable energy. Se evaluaron vinte artículos científicos publicados entre 2008 y 2019 en nueve revistas diferentes, con énfasis en la revista Renewable Energy. En relación con los países donde se desarrollaron los estudios, Bolivia, Costa Rica, China y Colombia se destacaron. Es importante señalar la necesidad de realizar más trabajos científicos con el objetivo de difundir y popularizar el conocimiento sobre la tecnología de la digestión anaeróbica de pequena escalas, principalmente en los países em desarrollo.
Aplicação do PROKNOW-C para seleção de portfólio bibliográfico e análise bibliométrica sobre captação e aproveitamento da água de chuva para fins não potáveis
Authors: Gomes dos Santos Giseli , Silva Vinicius Vanderley Miguel , Falcão da Silva Luciano , Umbelino Luis Felipe
Published: February 2022

A presente pesquisa teve como objetivo definir um Portfólio Bibliográfico (PB) relacionado a captação e aproveitamento da água de chuva, por meio da metodologia ProKnow-C, realizando a análise bibliométrica e sistêmica da literatura. Trata-se de um método desenvolvido por pesquisadores do LabMCDA-UFSC que propõe ao pesquisador formar um PB a partir de um tema de interesse, alinhado com sua pesquisa. Para alcançar o objetivo, foram formadas seis combinações de termos e palavras, por meio das variações dos eixos de pesquisa: Projeto; Construção; Sustentabilidade; Recursos Hídricos; Captação de água de chuva e Gestão da água, utilizando os operadores lógicos AND & OR para serem consultadas em inglês nas bases de dados Scopus e Web of Science (WoS). O processo de filtragem resultou em um portfólio com 22 artigos. Os resultados obtidos foram: (i) Water (Switzerland) como periódico de maior destaque; (ii) GHISI, Enedir como o autor com maior número de publicações e (iii) BUTLER, David; MEMON, Fayyaz Ali e WARD, Sarah como os autores mais citados. A partir do PB, identificamos que o autor com maior número de artigos, Enedir GHISI, é brasileiro e coordena algumas pesquisas relevantes sobre o tema na Universidade Federal de Santa Catarina.
Agrotóxicos na Água Potável: Considerações sobre os Municípios da Bacia Hidrográfica do rio Itabapoana
Authors: Souza Junior Ednilson Gomes
Published: February 2022

O setor agropecuário brasileiro, apoiado principalmente na produção de commodities para exportação, tem o uso intensivo de agrotóxicos como um de seus pilares. O uso intensivo de agrotóxicos está frequentemente associado a uma miríade de problemas ambientais e a diversos impactos na saúde humana. Com base em pesquisa publicada recentemente que identificou a presença de 27 agrotóxicos em amostras de água potável de municípios localizados em diferentes partes do Brasil, mapeamos a contaminação da água potável em 18 municípios da Bacia do Rio Itabapoana. Além disso, apresentamos uma visão geral das principais culturas cultivadas na Bacia do Rio Itabapoana. A partir desse panorama, identificamos lavouras que fazem uso intensivo de agrotóxicos, como café, milho, cana-de-açúcar, tomate, laranja e abacaxi. Além disso, identificamos também que, nos últimos 40 anos, mais de duas mil pessoas foram intoxicadas na Bacia do Rio Itabapoana. A presença de agrotóxicos na água para consumo humano em cinco municípios da Bacia do Itabapoana sugere que os municípios dessa região carecem de políticas públicas e investimentos tecnológicos voltados à modernização e à sustentabilidade dos processos produtivos.
Atitudes, Conhecimentos e Perspetivas dos Médicos Portugueses acerca das Terapêuticas Não Convencionais: Um Estudo Transversal
Authors: Nogueira Carlos , Brito de Sá Armando , Martins Ana Paula
Published: February 2022

Introdução: A utilização significativa das terapêuticas não convencionais, e o facto de estas não serem inócuas, torna imperativo que os médicos as conheçam, de forma a melhor aconselharem os seus doentes. Este estudo visou identificar as atitudes, conhecimentos e perspetivas dos médicos portugueses relativamente às terapêuticas não convencionais.Material e Métodos: Realizou-se um estudo observacional, analítico e transversal. Os médicos inscritos na Ordem dos Médicos portuguesa responderam a um questionário com respostas em escala de Likert de cinco pontos, dicotómicas e de escolha múltipla. As respostas às questões sobre crenças/convicções a respeito das terapêuticas não convencionais; aspetos relacionados com as terapêuticas não convencionais aprovadas pela Lei portuguesa; fontes usadas para obtenção de informação relativamente às terapêuticas não convencionais; e perguntas sobre as terapêuticas não convencionais no contexto nacional, foram analisadas com recurso ao SPSS v.27.0. Todas as conclusões foram tomadas ao nível de significância de 5%.Resultados: Dos 4334 médicos que responderam na íntegra ao questionário, 45,5% não se sentem confortáveis para conversar, argumentar e esclarecer os doentes a respeito das terapêuticas não convencionais. A maioria, 68,6%, considera que a competência em acupuntura da Ordem dos Médicos deveria permanecer disponível. No entanto, 72,4% dos médicos consideram que as terapêuticas não convencionais não deveriam ser incluídas no Serviço Nacional de Saúde.Conclusão: Os conhecimentos dos médicos portugueses relativamente às terapêuticas não convencionais parecem ser reduzidos, sendo que parte relevante dos inquiridos não se considera preparada para aconselhar os seus doentes.
Apresentação
Authors: Morato Edwiges , Tescari Neto Aquiles
Published: February 2022

Desde 2019 a Cadernos de Estudos Linguísticos (CEL), revista do Departamento de Linguística do Instituto de Estudos da Linguagem, da Universidade Estadual de Campinas, é editada no formato de publicação contínua (PC), em consonância com importantes plataformas nacionais e internacionais.  Em um único volume, os artigos são reunidos em dossiês temáticos e uma seção geral, marcada pela heterogeneidade de estudos e enfoques dos fenômenos linguísticos. A CEL integra uma plataforma de livre acesso e é disponibilizada pelo Portal de Periódicos (PPEC) da Unicamp. Neste volume 63, publicado em 2021, contamos com dois dossiês temáticos e uma seção geral.
Perfil clínico-epidemiológico e fatores associados às hepatites virais em Rondonópolis, MT
Authors: Santos Débora Aparecida da Silva , Goulart Letícia Silveira , Soares de Oliveira Jaynne , Ferreira Benevenuto Vitória Carolina
Published: February 2022

As hepatites virais são doenças de notificação compulsória, sendo consideradas agravos de saúde mundial. O objetivo deste estudo foi analisar o perfil clínico-epidemiológico e fatores associados aos casos de hepatites virais. Estudo transversal, retrospectivo e descritivo, realizado em Rondonópolis, MT, entre 2009 e 2018. A coleta de dados utilizou fonte secundária (Sistema de Informação de Agravos de Notificação). Após categorização das variáveis, a análise descritiva foi realizada pelo Software R e aplicado Teste Qui-Quadrado de Pearson. Foram notificados 840 casos de hepatites virais, apresentando perfil prevalente: sexo feminino, faixa etária de 20 a 59 anos, ensino fundamental, raça parda e residente na zona urbana; fonte mecânica de infecção por pessoa/pessoa, vírus B e forma clínica aguda. Houve significância estatística para variáveis faixa etária, escolaridade e forma clínica. Este estudo colabora para conscientizar as autoridades de saúde locais acerca da relevância desse agravo, sua magnitude e necessidade de estratégias de combate eficientes.
Desenvolvimento da liberdade no trabalho informal
Authors: Freiesleben Mariane , Pizzio da Silva Alex , Marques de Oliveira Nilton
Published: February 2022

Este trabalho alvorece uma discussão sobre o desenvolvimento da liberdade dentro do trabalho informal, analisando em termos do êxito entre ele e desenvolvimento econômico frente as privações, destituições e opressões extraordinárias diante dos problemas antigos e novos deste mundo globalizado. Neste artigo teórico é utilizada a revisão de literatura para atingir tal objetivo, o principal autor de análise é Amartya Sen, além de outros teóricos. Buscou-se esclarecer a noção do viver/sobreviver dentro do sistema de valores e capital social, paradoxos que formam um hibrido institucional entre o mundo formal e o informal, tendo no trabalho a constituição de um bem. Como conclusão, aponta-se a relevância da reflexividade do tema, bem como enfatiza que o desenvolvimento precisa ser democrático afetando o senso de bem público, implicando no sentido da liberdade e da obrigação na relação entre direitos e deveres que configuram a identidade social e política de cada um.
Síntomas depresivos, riesgo de abandono y mala adherencia al tratamiento en pacientes con tuberculosis sensible en un centro de salud de Lima, 2016-2020
Authors: Jonis-Jiménez Mauro , Guzman-Reinoso Roxana S. , Llanos-Tejada Félix K.
Published: February 2022

Objetivo: Determinar si la presencia de síntomas depresivos es un factor asociado al abandono y a la pobre adherencia al tratamiento en pacientes con TB sensible en un centro de salud de Lima entre 2016-2020. Materiales y métodos: Estudio de tipo no experimental, analítico, de cohorte, retrospectivo. En el Centro de Salud Materno- Infantil Buenos Aires de Villa. La información fue recogida de las historias clínicas, se estimó el riesgo para cohorte (Riesgo Relativo) y niveles de significancia estadística, con ayuda del programa SPSS Statistics 25. Resultados: La frecuencia de abandono del tratamiento fue de 18,3% (n=28), de pobre adherencia 42,5% (n=65) y de depresión 53,6% (n=82). Los síntomas depresivos se asociaron a abandono al tratamiento [RR= 2,16; IC95% (1,01-4,60)] y a pobre adherencia al tratamiento [RR=2,09; IC95% (1,36-3,22)]. Conclusiones: La depresión es un factor de riesgo significativamente asociado a abandono y a pobre adherencia al tratamiento en pacientes con tuberculosis sensible.
EXPANDED DENGUE SYNDROME
Authors: Vincent Agustinus , - Bramantono , Hadi Usman , Arifijanto Muhammad Vitanata
Published: February 2022

ABSTRACTDengue viral infection (DVI) is a debilitating arthropod-borne disease that has been rapidly spread in several regions of the world in recent years. The spectrum of disease varies from mild self-limiting illness to dengue fever (DF) to more severe and fulminating forms, i.e., dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS),and expanded dengue syndrome (EDS). The pathogenesis of EDS is not clear amid lack of studies on animal models. In the absence of in vitro experiments, disease spectrum is difficult to be elucidated and mimicked for humans.Recent advances on research on atypical complications of EDS demonstrate the involvement of other major organs such as the kidney, lung, heart, and central nervous system. Histopathological findings demonstrate the presence of hemorrhage, edema, and inflammatory infiltrates in these organs.The spectrum of Dengue viral infection varies from mild self-limiting illness to dengue fever to more severe and fulminating forms, i.e., dengue hemorrhagic fever, dengue shock syndrome, and expanded dengue syndrome.  Apart from the classical presentation, dengue infection can result in a myriad of unusual clinical manifestations, which are grouped under the title expanded dengue syndrome. These findings urge more focused and comprehensive investigations to explore such relationships so that high-risk patients could be identified immediately during their presentation to the hospitals.Keywords: Expanded dengue syndrome, Pathogenesis, Organ-specific manifestation
Tuberculous Lymphadenitis in Immunocompromised Patients: A Case Report
Authors: Wiriansya Edward Pandu , Djaharuddin Irawaty , Adam Andi Tiara Salengke
Published: February 2022

Introduction: Tuberculous lymphadenitis (TBLN) is a form of extra-pulmonary TB with clinical features ranging from lumps to abscesses. Human Immunodeficiency Virus (HIV) co-infection and diabetes mellitus alongside TBLN made the diagnosis and management exceptionally challenging. We reported 3 cases of TBLN, 2 among them had an existing HIV co-infection, and 1 had preexisting diabetes mellitus.Case: The first case, a 28-year-old man, previously diagnosed with HIV, complained of a lump in the neck; biopsy results suggested TBLN. The second case was a 36-year-old man with a neck abscess and HIV co-infection. Acid Fast Bacilli (AFB) pus was positive & Human Immunodeficiency Virus Enzyme-Linked Immunosorbent Assay (HIV ELISA) was reactive. The third case was a patient with a neck abscess with preexisting diabetes mellitus (DM) underwent wound debridement and was given anti-tuberculosis drugs.Conclusion: TBLN with HIV co-infection or diabetes had clinical features ranging from a painful lump to an abscess. The definitive diagnosis was taken by examining AFB from pus. If the abscess was more extensive than or equal to 3 cm, wound debridement was necessary. The primary treatment for TBLN was anti-tuberculosis drugs and required even greater attention if a patient had any preexisting comorbidities such as HIV and diabetes.
Is deficit irrigation with saline waters a viable alternative for winegrowers in semiarid areas?
Authors: Martínez-Moreno Alejandro , Pérez-Álvarez Eva , López-Urrea Ramon , Intrigliolo Diego , González-Centeno M. Reyes , Teissedre Pierre-Louis , Gil-Muñoz Rocío
Published: February 2022

Two of the main challenges of Mediterranean viticulture is low water quality and the risk of increasing concentrations of mineral salts in the root zone. This work was undertaken to study the impact of saline deficit irrigation on grape and wine phenolic composition, as well as on the sensory profile of the wines. The experiment was carried out during three consecutive years (2016-2018) in a commercial vineyard of cv. Monastrell (Vitis vinifera L.) grafted onto 1103P rootstock located in D.O. Jumilla (SE Spain). Three watering regimes were carried out: i) the control (“Control”): the vines were irrigated with water of standard quality, ii) Sulfate treatment (“Sul”): the vines were irrigated with saline water (Na₂SO₄ + MgSO4), and iii) Chloride treatment (“Chl”): the vines were irrigated with saline water (NaCl). The same amount of irrigation water was applied to all the treatments. The water electrical conductivity was 1.8 dS/m for Control and 5 dS/m for the saline treatments (Sul and Chl). Both the Sul and Chl treatments reduced the berry weight in all the study years compared to Control, although this difference was statistically significant in the last year only (p ≤ 0.05). No significant differences (p > 0.05) were observed in the grape quality parameters. However, the saline treatments slightly increased grape total soluble solids (TSS) in two out of the three study years compared to Control. Regarding the phenolic composition, no significant differences (p > 0.05) among treatments were found in grapes and wines. In general, the wines from vines irrigated with saline waters received the best scores by the panel in the sensory profile analysis. The use of saline waters could be employed in the case of water scarcity, as long as the vineyard is planted on a rootstock tolerant to salinity, such as 1103P, and the vineyard soil has a texture that favours leaching.
Social Media Addiction and Emotions During the Disaster Recovery Period? – The Moderating Role of Post-COVID Timing
Authors: Nur -A Yazdani Dewan Muhammad , Abir Tanvir , Yang Qing , Ahmad Jamee , Al Mamun Abdullah , Zainol Noor Raihani , Kakon Kaniz , Wang Shasha , Agho Kingsley E
Published: February 2022

Social media addiction has attracted the attention of researchers especially during the COVID era because negative emotions generated from the pandemic may have increased social media addiction. The present study aimed to investigate the role of negative emotions and social media addiction on health problems during and after the COVID lockdown. A survey was conducted with 2926 participants aged between 25 and 45 years. The data collection period was between 2nd September and 13th October 2020. Partial Least Square Structural Equation Modeling was conducted for data analysis by controlling the respondents' working time, leisure time, gender, education, and age. Our study showed that social media addiction and time spent on social media impact health. Interestingly, while anxiety about COVID increased social media addiction, fear about COIVD reduced social media addiction. Also, long working hours contributed most to people’s health issues, and its impact on social media addiction and hours was much higher than negative emotions, where males faced more health challenges than females. The impacts of negative emotions generated by the COVID on social media addiction and health issues should be reconsidered. Government and employers' control of people's working time stress should prioritize solving social media addiction-related issues.
Penyelenggaraan Usaha Syariah Hotel Solo Sebelum Peraturan Menteri Pariwisata Nomor 11 Tahun 2016 Tentang Pencabutan Peraturan Menteri Pariwisata dan Ekonomi Kreatif Nomor 2 Tahun 2014 Tentang Pedoman Penyelenggaraan Usaha Hotel Syariah
Authors: Septiningrum Shintya Yulfa
Published: February 2022

Penelitian ini bertujuan untuk mengetahui penyelenggaraan konsep syariah di Syariah Hotel Solo sebelum adanya penetapan Peraturan Menteri Pariwisata Nomor 11 Tahun 2016 tentang Pencabutan Peraturan Menteri Pariwisata dan Ekonomi Kreatif Nomor 2 Tahun 2014 tentang Pedoman Penyelenggaraan Usaha Hotel Syariah. Penelitian ini menggunakan penelitian hukum empiris yang bersifat deskriptif. Pendekatan yang digunakan adalah pendekatan kualitatif. Lokasi penelitian adalah Syariah Hotel Solo. Penelitian ini menggunakan sumber data primer dan sekunder yang diperoleh melalui wawancara terhadap pihak Syariah Hotel Solo. Hasil penelitian menunjukkan bahwa penyelenggaraan konsep syariah di Syariah Hotel Solo sudah sesuai dengan pedoman penyelenggaraan usaha hotel syariah karena sudah memenuhi kriteria mutlak dan tidak mutlak yang berada di Peraturan Menteri Pariwisata dan Ekonomi Kreatif Nomor 2 Tahun 2014 tentang Pedoman Penyelenggaraan Usaha Hotel Syariah dibuktikan dengan adanya sertifikasi halal dan sertifikat halal-2
Unusual Presentation of a Clavicle Fracture Locked Under the First Rib with Global Brachial Plexus Injury
Authors: Babu T. Shanmukha , Devendra Agraharam , Venkatramani Hari , Bharadwaj Praveen , Dheenadhayalan Jayaramaraju , Rajasekaran Shanmuganathan
Published: February 2022

Case:

Thoracic penetration of the medial half of clavicle fracture is rare and can be life-threatening and limb-threatening because of its proximity to the pleura and neurovascular structures. We report an unusual presentation of the medial portion of clavicle fracture locked under the first rib associated with the pneumothorax and global brachial plexus palsy successfully reduced by gentle manipulation. Partial injury to the subclavian vein was repaired. Nerve transfer was performed for brachial plexus palsy. The patient showed good functional recovery.

Conclusion:

Reduction of locked intrathoracic clavicle fracture was performed safely by gentle manipulation. Subsequent appropriate interventions for the brachial plexus palsy led to a good outcome.
Compartment Syndrome Secondary to Intraosseous Access Abutting Tibial Stem Cement Mantle of a Total Knee Arthroplasty
Authors: Chughtai Morad , Pang Aaron , Khan Taiba , Cantrell William A. , Mesko Nathan W. , Kamath Atul F.
Published: February 2022

Update

This article was updated on June 15, 2022, because of a previous error. One of the author's names was incorrect. The correct name is William A. Cantrell.

An erratum (JBJS Case Connect. 2022;12[2]:e21.00655ER) has been published for this article.

Case:

A 79-year-old man 6 days status-post left total knee arthroplasty (TKA) presented to our institution from an outside hospital (OSH) after a suspected STEMI and ventricular fibrillation arrest. At the OSH, intraosseous (IO) access was placed in his right tibia. Orthopaedics was consulted for compartment syndrome at the IO access site. X-rays demonstrated this was secondary to the IO access abutting the cement mantle of a stemmed tibial component of a remote TKA, for which the patient required emergent fasciotomies.

Conclusions:

Healthcare providers should be cognizant of potential orthopaedic hardware that can impede proper introduction of IO access.
Review of Acute Inflammatory Demyelinating Polyradiculoneuropathy
Authors: Palombo Gabriela , Hoppe Blake
Published: February 2022

On average, 97% of patients in North America and Europe diagnosed with Guillain-Barré syndrome have a specific subtype known as acute inflammatory demyelinating polyradiculoneuropathy (AIDP). AIDP is suspected to be a result of proinflammatory cytokines causing demyelination, specifically within the peripheral nervous system, in response to stress. Events that precede the onset of AIDP include gastrointestinal or respiratory infections, surgeries, and trauma. AIDP primarily presents with acute ascending paralysis and areflexia. Diagnosis of AIDP is confirmed by nerve conduction studies (NCSs) with electromyography (EMG) and lumbar puncture for cerebral spinal fluid (CSF) analysis. NCS/EMG is used to assess the peripheral nerve function, and serial examinations are often needed. CSF analysis is looking to identify albumino-cytological dissociation. Most commonly, intravenous immunoglobulin is used to treat AIDP with plasmapheresis being the second most common treatment. Prognosis is dependent on the remyelination process but overall is relatively good. More than 80% of patients can walk independently within one year of recovery.
The Validity of Mobile Learning-Based Ryleac Learning Tools for Strengthening Student Character
Authors: Abdjul Tirtawaty , Kurniasari Septiana , Kadir Samad
Published: February 2022

Mobile learning-based learning is very appropriate to use in learning today, where all Indonesian students, especially students in Gorontalo Province, apply online mode-based learning. So that students are actively involved in learning and interact through mobile learning media to improve student character, the learning model that needs to be applied includes the Ryleac learning model. This study aims to produce a mobile learning-based Ryleac learning device for strengthening student character that is suitable for use in learning for class XI students of SMA Gorontalo. This research is classified as a Quasi Experiment research with a posttest only control group design. Based on the validity test, from the validation results by experts, it was found that the average ryleac-based mobile learning learning device for RPP obtained a validity value of 0.858 (SV), LKPD obtained a validity value of 0.870 (SV), teaching materials obtained a validity value of 0.859 (SV), THB obtained a validity value of 0.841 (V) and the student character observation sheet obtained a validity value of 0.889 (SV). Based on these data, the ryleac learning device based on mobile learning is feasible to use in learning.
Prevención del ahogamiento en la legislación española de piscinas
Authors: Gámez de la Hoz Joaquín , Padilla Fortes Ana , Padilla-Ruiz Marta
Published: February 2022

Antecedentes: Las lesiones en el medio acuático guardan relación con el cumplimiento efectivo de las disposiciones legales que regulan las piscinas.
Objetivos: Identificar las medidas de seguridad frente al riesgo de ahogamiento previstas en la legislación sanitaria española de piscinas y proponer soluciones normativas para orientar los esfuerzos preventivos.
Método: Diseño descriptivo basado en el análisis documental de los 17 reglamentos sanitarios de piscinas de las Comunidades Autónomas de España. Se seleccionaron los preceptos normativos relativos a la protección y prevención frente al riesgo de ahogamiento, categorizados en cuatro sectores de actuación: Diseño de la zona de baño, especificaciones técnicas, servicio de salvamento acuático y normas para usuarios.
Resultados: Hallamos una gran variabilidad de requerimientos normativos susceptibles de mejoras. Faltan estándares de seguridad en las tomas de recirculación de agua del vaso para evitar el atrapamiento del bañista. Se prestó poca atención a la provisión de medios y condiciones de prestación del servicio de salvamento acuático. El papel de los adultos en la custodia y supervisión de menores durante el baño tiene una mención laxa en las normas. El régimen interno de uso de las piscinas adolece de normas desagregadas por grupos vulnerables con mayor predisposición a sufrir ahogamientos.
Conclusiones: La prevención del ahogamiento demanda un enfoque multidimensional que introduzca cambios en las disposiciones normativas, adecuándolas a sus fines para aumentar los niveles de seguridad en las piscinas. Nuestros hallazgos son válidos para encauzar los esfuerzos a nivel legislativo para reducir el impacto de los ahogamientos.
Palabras clave: Peligros ambientales, investigación normativa, mortalidad, supervisión, promoción de la salud.
Cómo optimizar la comunicación entre profesores y familias en las clases de estimulación acuática infantil
Authors: Fonseca Pinto Rita
Published: February 2022

Antecedentes: La presencia de los padres en las clases de estimulación acuática infantil es muchas veces descrita por los profesores como un desafío, llegando por veces a ser identificada como un problema. Cuando esta es nuestra visión es importante parar para reflexionar y encontrar una perspectiva qué pueda ser realmente posibilitadora de la relación que se desarrolla en esto lugar lleno de oportunidad.
Objetivo: con esto articulo tenemos como intención sensibilizar para la conciencia y cambio de actitud de los educadores acuáticos en relación a las figuras parentales y/o al adulto acompañante del niño en las clases infantiles.
Método: presentando un conjunto de conceptos y aportes con ejemplos para originar nuevo conocimiento y estrategias de actuación, enfocados en generar un impacto positivo en el desarrollo integral del niño y bienestar de la familia.
Resultados: Nuestra práctica tiene un alcance personal y social. Escucharnos con atención plena, sin juzgar, desde un hogar de empatía, conciencia emocional y conocimiento son algunos ejemplos para desarrollar, pues el clima emocional de la clase es construido por nosotros. Somos el barómetro emocional de la clase y por esto tenemos impacto en las emociones y consecuentes comportamientos.
Conclusiones: Desarrollar las competencias acuáticas en la etapa infantil, con profesionales que están atentos al sentir, al hacer y al estar de sus alumnos, de modo respetuoso, no debe de ser un privilegio, debe de estar al alcance de todos. Es nuestro, en cuanto educadores acuáticos, la responsabilidad de conseguirlo.
Palabras clave: comunicación, estimulación acuática, infancia, aprendizaje, conexiones
Effects of Supplementation of Ferulic Acid (FA) on Growth Performance, Activities of Digestive Enzymes, Antioxidant Capacity and Lipid Metabolism of Large Yellow Croaker (Larimichthys crocea) Larvae
Authors: Xu Wenxuan , Huang Wenxing , Yao Chuanwei , Liu Yongtao , Yin Zhaoyang , Mai Kangsen , Ai Qinghui
Published: February 2022

A 30-day feeding trial was conducted to investigate effects of supplementation of ferulic acid (FA) on growth performance, activities of digestive enzyme, antioxidant responses and lipid metabolism of the large yellow croaker (Larimichthys crocea) larvae. Four isonitrogenous and isolipidic micro-diets were formulated with graded levels of FA (0, 20, 40, and 80 mg/kg). Results showed that larvae fed the diet with supplementation of 40 mg/kg FA had significantly higher survival rate, while the specific growth rate was significantly higher in larvae fed diets with 40 and 80 mg/kg FA than the control group (P < 0.05). Activities of trypsin in pancreatic segments (PS) and intestinal segments, lipase in PS and Alkaline phosphatase in brush border membrane were significantly increased by supplementation of FA compared to the control group (P < 0.05). Supplementation of FA significantly increased activities of total superoxide dismutase and catalase, and reduced the malondialdehyde content compared to the control group. Meanwhile, activities of lysozyme, total nitric oxide synthase and nitric oxide content were significantly improved by supplementation of FA in diets. Furthermore, results revealed that supplementation of FA reduced the lipid accumulation in visceral mass of larvae fed the diet with 40 mg/kg FA probably through inhibiting gens expression of lipogenesis-related genes (scd1, fas and dgat2) and promoting expression of lipid catabolism-related genes (aco, cpt1, and hl). In conclusion, appropriate supplementation of 40 mg/kg FA could improve the survival and growth performance of large yellow croaker larvae through increasing digestive, antioxidant capacity and promoting lipid metabolism.
Using phytoplankton taxonomy diversity indices to assess trophic states in the biggest quake lake in China
Authors: Cai yang , Qi lin , MA chao , Lu xinxin , Fan Yawen
Published: February 2022

Water eutrophication is widely associated with the explosion of phytoplankton productivity and the overdominance of some harmful phytoplankton species. Phytoplankton diversity indices are useful tools for describing trophic states. The relationship between phytoplankton diversity indices and trophic states is a relevant approach to assess water quality, but this approach has rarely been used to evaluate water quality in large quake lakes. To test the usefulness of phytoplankton diversity indices in water quality assessment, we investigated the taxonomy diversity-trophic state index (TSI) relationships for lakes in the second-largest quake lake worldwide, (Jingpo Lake, in China). Our results showed that Cyanophyta and Bacillariophyta were abundant at most stations during the study period. The Bacillariophyta assemblage was closely associated with organic pollution. The Margalef index and Shannon–Weaver index were relevant tools for evaluating trophic changes during the study period. The Pielou index had a weak ability to describe nutrient changes. Our findings highlight that phytoplankton taxonomy diversity indices are relevant tools in water quality assessment, but a selection of the fit index is necessary.
Reactivity-Tunable Palladium Precatalysts with Favorable Catalytic Properties in Suzuki–Miyaura Cross-Coupling Reactions
Authors: Liang Siou-Wei , Guo Yingjie , Lee Wan-Ching , Zeng Pin-Rui , Lin Tzu-Hao , Lu I-Chung , Chang Yu-Chang
Published: February 2022

In this study, two (HO)R2P→Pd(II)Cl2←NHC precatalysts (1s) were designed and synthesized. Using these precatalysts, yields of unreactive aryl chloride, benzyl chloride, and benzoyl chloride were obtained in three to tens of minutes. Upon deprotonation, density-functional theory calculations and electrospray ionization mass spectrometry revealed that NHC was dissociated from the deprotonated precatalysts. Subsequently, the anionic (O−)R2P→Pd(II)Cl2 species could be reduced using ethoxide to form Pd(0) catalytic species. The cation and anion functions of salt additives were elucidated. The cation size could be used to modulate the catalytic properties of 1s through outer-sphere electrostatic interactions between the coordinated R2P(O−) and alkali metal ions. Through this study, we newly designed Pd(II) precatalysts with superb catalytic properties that are stable and highly efficient.
Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
Authors: Karbiener Michael , Farcet Maria R , Zollner Andreas , Masuda Taisei , Mori Mitsuhiro , Moschen Alexander R , Kreil Thomas R
Published: February 2022

SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine, calibrated against the WHO international SARS-CoV-2 antibody standard, and further supports the use of neutralizing antibody levels as correlate of protection.
Radiofluorination of A Highly Potent ATM Inhibitor As A Potential PET Imaging Agent
Authors:   Claudia Fraser1, Ajenjo Javier , Veal Mathew , Dias Gemma , Chan Chung , O’Neill Edward , Destro Gianluca , Lau Doreen , Pacelli Anna , Gouverneur Veronique , Hueting Rebekka , Cornelissen Bart
Published: February 2022

Purpose: Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selection in a move towards more personalised medicine. The aim of this study was to synthesise and investigate the first 18F-labelled ATM inhibitor [18F]1 for non-invasive imaging of ATM protein and ATMi pharmacokinetics.Methods: Radiofluorination of a confirmed selective ATM inhibitor (1) was achieved through substitution of a nitro-precursor with [18F]fluoride. Uptake of [18F]1 was assessed in vitro in H1299 lung cancer cells stably transfected with shRNA to reduce expression of ATM. Blocking studies using several non-radioactive ATM inhibitors assessed binding specificity to ATM. In vivo biodistribution studies were performed in wild-type and ATM-knockout C57BL/6 mice using PET/CT and ex vivo analysis. Uptake of [18F]1 in H1299 tumour xenografts was assessed in BALB/c nu/nu mice.Results: Nitro-precursor 2 was synthesised with an overall yield of 12%. Radiofluorination of 2 achieved radiochemically pure [18F]1 in 80 ± 13 min with a radiochemical yield of 20 ± 13% (decay-corrected) and molar activities up to 80 GBq/μmol (n=11). In vitro, cell associated activity of [18F]1 increased over one hour, and retention of [18F]1 dropped to 50% over two hours. [18F]1 uptake did not correlate with ATM expression, but could be reduced significantly with an excess of known ATM inhibitors, demonstrating specific binding of [18F]1 to ATM. In vivo, fast hepatobiliary clearance was observed with tumour uptake ranging 0.13-0.90%ID/g after one hour.Conclusion: Here we report the first radiofluorination of an ATM inhibitor and its in vitro and in vivo biological evaluations, revealing the benefits but also some limitations of 18F-labelled ATM inhibitors.
High-flow Nasal Cannula Oxygen Therapy as Initial Respiratory Management for Severe COVID-19-induced Respiratory Failure: a Single-center Observational Study
Authors: Nakai Toshihiro , Umemura Yutaka , Nishida Takeshi , Mitsuyama Yumi , Watanabe Atsushi , Fujimi Satoshi
Published: February 2022

Background: The efficacy and safety of high-flow nasal cannula (HFNC) oxygen therapy in severe respiratory failure, especially induced by COVID-19, has not been fully elucidated. We aimed to examine the usefulness of HFNC compared to invasive mechanical ventilation (IMV) as initial respiratory management for severe COVID-19-induced respiratory failure.Methods: In this retrospective observational study, we enrolled and categorized the patients with COVID-19-induced severe respiratory failure who were intolerant of conventional oxygen therapy into two groups: 1) patients who initially received HFNC (HFNC group) and 2) patients who initially underwent IMV (IMV group). The primary outcome was in-hospital mortality. The secondary outcomes were ventilator-free days within 28 days, intensive care unit (ICU)-free days within 28 days, and respiratory failure days defined as the length from day 1 to achieving successful weaning from both HFNC and IMV.Results: We analyzed 182 patients (HFNC group, n=81; IMV group, n=101). There was no difference in in-hospital mortality between the two groups (19% in the HFNC group vs. 25% in the IMV group, p=0.37). Initial use of HFNC was not associated with mortality in the univariate analysis (OR, 0.69; CI, 0.34–1.42; p=0.31) and inverse probability of treatment weighting analysis using propensity scoring (OR, 1.01; CI, 0.37–2.77; p=0.984). Ventilator-free days within 28 days were significantly longer in the HFNC group than those in the IMV group (median, 22 days [interquartile range (IQR), 2–28 days] vs. median, 14 days [IQR, 0–20 days], p<0.001). ICU-free days within 28 days were significantly longer in the HFNC group than those in the IMV group (median, 23 days [IQR, 0–28 days] vs. median, 15 days [IQR, 0–20 days], p<0.001). Respiratory failure days were relatively shorter in the HFNC group, but the difference was not statistically significant (p=0.071).Conclusions: Among patients with severe COVID-19-induced respiratory failure, HFNC compared to IMV resulted in a statistically significant increase in ventilator-free and ICU-free days within 28 days without increasing in-hospital mortality. This study showed the potential for HFNC to be an effective alternative to IMV as initial respiratory management for severe COVID-19-induced respiratory failure.
EGOC inhibits TOROID polymerization by structurally activating TORC1
Authors: Prouteau Manoël , Bourgoint Clélia , Felix Jan , Bonadei Lenny , Sadian Yashar , Gabus Caroline , Savvides Savvas , Gutsche Irina , Desfosses Ambroise , Loewith Robbie
Published: February 2022

Target Of Rapamycin Complex 1 (TORC1) is a protein kinase controlling cell homeostasis and growth in response to nutrients and stresses. Glucose depletion triggers a pronounced redistribution of TORC1 from a dispersed localisation over the vacuole surface into a large, inactive condensate called a TOROID (TORC1 Organised in Inhibited Domain). However, the molecular mechanisms governing this transition were unclear. Here, we show that acute depletion and repletion of EGO Complex (EGOC) activity is sufficient to control TOROID distribution, independently of other nutrient-signalling pathways. A 3.8 Å-resolution 3D reconstruction of TORC1 from TOROID cryo-EM data together with interrogation of key interactions in vivo provided structural insights into TORC1-TORC1’ and TORC1-EGOC interaction interfaces. These data support a model in which glucose-dependent activation of EGOC triggers binding to TORC1 at an interface required for TOROID assembly, resulting in inhibition of TORC1 polymerisation and release of active TORC1 dimers.
The association between the flat feet and the symptoms of knee osteoarthritis
Authors: Cheng Cheng-Kung , Zhang Min , Nie Mao-dan , Qi Xin-zheng , Ke Song , Li Jun-wei , Shui Yang-yang , Zhang Zhuo-yue , Wang Min
Published: February 2022

Objective: The purpose of this study was to assess the association between the flat feet and the symptoms of knee osteoarthritis (OA). Methods: 95 participants with knee osteoarthritis were recruited for this study. Knee osteoarthritis was evaluated using a combination of Kellgren-Lawrence (K-L) grade, femoral-tibial angle (FTA), knee pain and physical function. The Arch Index (AI) was used to assess the severity of flat feet, with subjects being divided into groups with no flat feet, mild flat feet and severe flat feet. A chi-square test, continuous variable t test and Mann-Whitney U test were used to compare differences in K-L grade, knee pain, physical function and femoral-tibial angle. Regression analysis was performed to assess the correlation between the flat feet and the characteristics of knee osteoarthritis. Results: Flat feet was associated with a significantly increased risk of having a larger varus angle (beta: -2.306; 95% confidence interval (CI): -3.703, -0.909; p = 0.001), higher pain score (beta: 0.356; 95% CI: 0.130, 0.582; p = 0.002) and greater loss of physical function (beta: 0.281; 95% CI: 0.071, 0.491; p = 0.009). Severe grades of flat feet were associated with an increased risk of pain (beta: -0.289; 95% CI: -0.543, -0.035; p = 0.026). However, the severity of flat feet was not associated with K-L grade, FTA or physical function. Conclusion: There was a significant association between the presence of flat feet and symptoms of knee OA, and severe flat feet was found to aggravate OA-related knee pain. Active treatment to correct flat feet is recommended to relieve symptoms associated with knee OA. Level of Evidence: Level II
SWI2/SNF2 Chromatin Remodeling ATPases SPLAYED and BRAHMA Control Embryo Development in Rice
Authors: Xun Qian , Mei Min , Song Ye , Rong Chenyu , Liu Jiajun , Zhong Tianhui , Ding Yanfeng , Ding Chengqiang
Published: February 2022

In plants, SPLAYED (SYD) and BRAHMA (BRM) encode chromatin remodeling ATPases that use the energy derived from ATP hydrolysis to restructure nucleosomes and render certain genomic regions available to transcription factors. However, the function of SYD and BRM on rice growth and development is unknown. Here, we constructed ossyd and osbrm mutants using CRISPR/Cas9 technology and analyzed the effects of mutations on rice embryo development. We discovered that the ossyd and osbrm mutants exhibited severe defects during embryonic development, whereas endosperm development was normal. These results indicated that the development of the embryo and endosperm is independent of each other. Consequently, the ossyd- and osbrm-null mutants did not germinate due to the abnormal embryos. Furthermore, we observed the embryos of ossyd- and osbrm-null mutants, and they indeed had distinct differentiation defects in shoot establishment, acquired during embryogenesis. To verify the function of OsSYD and OsBRM in embryogenesis, we measured the transcript levels of marker genes at different stages. Compared with wild-type, the expression levels of multiple OSH genes were significantly reduced in the mutants, which was consistent with the defective shoot establishment phenotypes. The interaction between SYD and RICE FLORICAULA/LFY (RFL) was revealed using a yeast two-hybrid screening system, suggesting that the interaction between the LFY homolog and chromatin remodeling ATPases are ubiquitous in plants. Collectively, our findings provide the basis for elucidating the function of OsSYD and OsBRM during embryo development in rice.
Is monotherapy with a beta-lactam antibiotic inferior to combination therapy with a beta-lactam antibiotic and rifampicin in treating prosthetic joint infections? A retrospective study.
Authors: Jalal Bamo , Murlasits Veronika , Boel Jonas B. , Sonntag Jesper , Michelsen Morten , Gottlieb Hans , Arpi Magnus , Nielsen Lene
Published: February 2022

Background: The use of rifampicin in Prosthetic joint infections (PJI’s) is widely used, although the evidence of its effectiveness is sparce. The aim of this study was to retrospectively examine if monotherapy with a beta-lactam antibiotic was inferior to combination therapy with a beta-lactam antibiotic and rifampicin in the treatment of PJI’s of the hip and knee caused by beta-lactam sensitive staphylococci treated with debridement, antibiotics, and implant retention (DAIR). Methods: Ninety-one patients with beta-lactam sensitive PJI’s of the hip and knee from two hospitals in Denmark received DAIR between January 1, 2004 – December 31, 2013. Fifty-one patients were postoperatively treated with beta-lactam antibiotic monotherapy (control group) at one institution, while at a second institution, 40 patients received combination therapy with a beta-lactam antibiotic and rifampicin. Patients were followed for two years from the date the DAIR procedure was carried out. Hazard Ratios (HR) were calculated using Cox proportional hazards regression analysis along with 95% confidence intervals (CI). Results: No significant difference in arthroplasty removal within two years was found between the two groups; rifampicin group 13 (32.5 %) vs. control group 20 (39.2 %; p=0.51). Comparing arthroplasty survival between the rifampicin group and the control group, a statistically significant difference was not found ((HR) 0.81, 95% CI 0.40 - 1.63, p = 0.55). Conclusion: This study suggests that monotherapy with a beta-lactam is not inferior to combination therapy with a beta-lactam and rifampicin in treating staphylococcal PJI’s with DAIR. We suggest that monotherapy with a beta-lactam in DAIR may be a safe option when treating staphylococcal PJI’s.