bluuebunny/crossref_metadata_2025 huggingface dataset:
Botulinum Injection Into the Proximal Intestinal Wall of Diet-Induced Obese Mice Leads to Weight Loss and Improves Glucose and Fat Tolerance
Authors: Sundaresan Sinju , Antoun Joseph , Banan Babak , Adcock Jamie , Johnson Connor , Claire Brendan , Dixon Kala , Flynn Joyce , Shibao Cyndya A. , Abumrad Naji
Published: April 2022

Botulinum neurotoxin (available commercially as BOTOX) has been used successfully for treatment of several neuromuscular disorders, including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of Botox into the proximal intestinal wall of diet-induced obese (DIO) mice induces weight loss and reduces food intake. This was associated with amelioration of hyperglycemia, hyperlipidemia, and significant improvement of glucose tolerance without alteration of energy expenditure. We also observed accelerated gastrointestinal transit and significant reductions in glucose and lipid absorption, which may account, at least in part, for the observed weight loss and robust metabolic benefits, although possible systemic effects occurring as a consequence of central and/or peripheral signaling cannot be ignored. The observed metabolic benefits were found to be largely independent of weight loss, as demonstrated by pair-feeding experiments. Effects lasted ∼8 weeks, for as long as the half-life of Botox as reported in prior rodent studies. These results have valuable clinical implications. If the observed effects are translatable in humans, this approach could lay the foundation for therapeutic approaches geared toward robust and sustained weight loss, mimicking some of the benefits of bariatric operations without its cost and complications.
Low-Dose Dasiglucagon Versus Oral Glucose for Prevention of Insulin-Induced Hypoglycemia in People With Type 1 Diabetes: A Phase 2, Randomized, Three-Arm Crossover Study
Authors: Laugesen Christian , Ranjan Ajenthen G. , Schmidt Signe , Nørgaard Kirsten
Published: April 2022

OBJECTIVE

To compare the efficacy of low-dose subcutaneous dasiglucagon with oral glucose for prevention of insulin-induced hypoglycemia in people with type 1 diabetes.

RESEARCH DESIGN AND METHODS

Twenty adults with type 1 diabetes using multiple daily injection or insulin pump therapy completed a phase 2, randomized, three-arm crossover study. On each study visit, an individualized subcutaneous insulin bolus was administered aiming for a plasma glucose (PG) concentration of 3.0 mmol/L (54 mg/dL). When a PG concentration of 4.5 mmol/L (81 mg/dL) was reached, 15 g oral glucose (CHO) from dextrose tablets, 80 µg dasiglucagon (D80), or 120 µg dasiglucagon (D120) was administered. PG was measured frequently for the following 180 min.

RESULTS

Hypoglycemia (<3.9 mmol/L [70 mg/dL]) occurred in 10 participants after CHO, in 5 after D80, and in 4 after D120 (CHO vs. D80, P = 0.096; CHO vs. D120, P = 0.034). Time spent in hypoglycemia (<3.9 mmol/L [70 mg/dL]) was 14%, 7%, and 6% for CHO, D80, and D120, respectively (P = 0.273). The median time (95% CI) from intervention to first increase in PG of 1.1 mmol/L (20 mg/dL) was 30 (25–50), 15 (15–20), and 15 (15–20) minutes for CHO, D80, and D120, respectively (CHO vs. D80, P = 0.006; CHO vs. D120, P = 0.003). Episodes of nausea were numerically, but not significantly, higher after dasiglucagon administration. No significant differences in visual analog scale-assessed adverse effects were observed between interventions.

CONCLUSIONS

Low-dose dasiglucagon safely and effectively prevented insulin-induced hypoglycemia with a faster glucose-elevating profile than oral glucose.
The Importance of Office Blood Pressure Measurement Frequency and Methodology in Evaluating the Prevalence of Hypertension in Children and Adolescents With Type 1 Diabetes: The SWEET International Database
Authors: Vazeou Andriani , Tittel Sascha R. , Birkebaek Niels H. , Kordonouri Olga , Iotova Violeta , Piccini Barbara , Saboo Banshi , Pundziute Lyckå Auste , Seget Sebastian , Maahs David M. , Stergiou George
Published: April 2022

OBJECTIVE

The prevalence of hypertension is higher in children and adolescents with type 1 diabetes (T1D) compared with those without. This retrospective analysis of a large cohort of children and adolescents with T1D from the SWEET (Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) international consortium of pediatric diabetes centers aimed to 1) estimate the prevalence of elevated office blood pressure (BP) and hypertension and 2) investigate the influence of BP measurement methodology on the prevalence of hypertension.

RESEARCH DESIGN AND METHODS

A total of 27,120 individuals with T1D, aged 5–18 years, were analyzed. Participants were grouped into those with BP measurements at three or more visits (n = 10,440) and fewer than 3 visits (n = 16,680) per year and stratified by age and sex. A subgroup analysis was performed on 15,742 individuals from centers providing a score indicating BP measurement accuracy.

RESULTS

Among participants with BP measurement at three or more visits, the prevalence of hypertension was lower compared with those with fewer than three visits (10.8% vs. 17.5% P < 0.001), whereas elevated BP and normotension were higher (17.5% and 71.7% vs. 15.3% and 67.1%, respectively; both P < 0.001). The prevalence of hypertension and elevated BP was higher in individuals aged ≥13 years than in younger ones (P < 0.001) and in male than female participants (P < 0.001). In linear regression models, systolic and diastolic BP was independently determined by the BP measurement methodology.

CONCLUSIONS

The estimated prevalence of elevated BP and hypertension in children and adolescents with T1D is ∼30% and depends on the BP measurement methodology. Less frequent BP evaluation may overestimate the prevalence of hypertension.
Botulinum Injection into the Proximal Intestinal Wall of Diet-induced Obese Mice Leads to Weight Loss and Improves Glucose and Fat Tolerance
Authors: Sundaresan Sinju , Antoun Joseph , Banan Babak , Adcock Jamie , Johnson Connor , Claire Brendan , Dixon Kala , Flynn Joyce , Shibao Cyndya A. , Abumrad Naji
Published: April 2022

Botulinum neurotoxin (available commercially as BOTOX®) has been used successfully for treatment of several neuromuscular disorders including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of BOTOX® into the proximal intestinal wall of diet-induced obese (DIO) mice induces weight loss and reduces food intake. This was associated with amelioration of hyperglycemia, hyperlipidemia, and significant improvement of glucose tolerance without alteration of energy expenditure. We also observed accelerated gastrointestinal transit and significant reductions in glucose and lipid absorption which may account at least, in part to the observed weight loss and robust metabolic benefits, although possible systemic effects occurring as a consequence of central and/or peripheral signaling cannot be ignored. The observed metabolic benefits were found to be largely independent of weight loss as demonstrated by pair-feeding experiments. Effects lasted until about 8 weeks, for as long as the half-life of Botox as reported in prior rodent studies. These results have valuable clinical implications. If the observed effects are translatable in humans this approach could lay the foundation for therapeutic approaches geared toward robust and sustained weight loss, mimicking some of the benefits of bariatric surgeries without its cost and complications. 
Study on shear buckling failure of laser-welded dissimilar aluminum alloy (Al-Li-2099/Al-Li-S4) stiffened panel
Authors: Liu Hui , Lei Zhenkun , Jiang Hao , Zou Jianchao , Guo Zhenfei , Bai Ruixiang , Wang Dawei
Published: April 2022

Laser welding of L-shaped aluminum alloy joints is of great significance in lightweight and efficient manufacturing of thin-wall reinforced aerospace structures. Shear performance is an important reference index for the structural design of aluminum alloy-reinforced panels. In this study, in-plane shear experiments of a continuous double-sided laser welded dissimilar Al-Li alloy (Al-Li-2099/Al-Li-S4) stiffened thin-walled panels were carried out. The deformation and buckling mode evolution of the stiffened panel were measured by the combination of fringe projection profilometry and strain gauge measurement. The results show that in the macroaspect, the stiffened panel first exhibits local skin buckling and then develops into overall buckling along the diagonal tensile direction. Finally, the stiffened panel shows weld desoldering failure. Metallographic examination and scanning electron microscopy were performed on the L-shaped joints at different positions of the stiffened panel. The microstructure observation shows that the weld was composed of a nondendritic equiaxed zone, a columnar dendritic zone, and an equiaxed dendritic zone. The failure mode of the weld is mainly brittle fracture with a small amount of shear dimples, indicating that the welded seam of the stiffened panel under the shear load is tensile shear coupling. After the force reaches material strength, the crack nucleates in the weld and extends along the weld until it penetrates the whole weld. This shows that the mechanical properties of the weld microstructure are closely related to the macroshear properties of the stiffened panel.
Sledy vzaimodejstviya finnoyazychnogo, slavyanskogo i tyurkoyazychnogo naseleniya v sovremennom genofonde i ih otrazhenie v farmakogenetike
Authors: Балановская Е. В. , Горин И. О. , Пономарев Г. Ю. , Пылёв В. Ю. , Петрушенко В. С. , Маркина Н. В. , Мамаева А. Д. , Ларин А. К. , Агджоян А. Т.
Published: April 2022

Aktual'nost' problemy geneticheskogo vklada doslavyanskogo naseleniya v genofond russkih populyacij i geneticheskogo sleda vtorzheniya Zolotoj ordy so vremenem lish' vozrastaet. Vklyuchenie v arsenal polnogenomnyh dannyh o shirokom kruge populyacij pozvolyaet iskat' naibolee korrektnye resheniya etoj problemy. Cel'yu raboty byl poisk sledov vzaimodejstviya genofondov finnoyazychnyh, slavyanskih i tyurkoyazychnyh narodov Central'noj Rossii i Povolzh'ya i ih otrazheniya v farmakogeneticheskom landshafte po dannym o 248 genomah predstavitelej 47 populyacij 9 etnosov s pomoshch'yu modelirovaniya i kartografirovaniya predkovyh komponent ADMIXTURE. Vyyavleny specifichnye komponenty dlya kazhdogo iz finnoyazychnyh narodov, no lish' predkovye komponenty mordvy rasprostraneny vo vsekh populyaciyah regiona nezavisimo ot ih yazykovoj prinadlezhnosti. Genofondy russkih populyacij vklyuchayut 80% sobstvennoj komponenty, 19% vklada finnoyazychnyh narodov, 1% central'noaziatskogo vliyaniya. Genofond tatar yavlyaetsya kombinaciej vsekh vyyavlennyh predkovyh komponent, vklyuchaya 81% vklada finnoyazychnyh narodov i lish' 12% central'noaziatskogo vklada, chto zatrudnyaet ocenku ih vliyaniya na russkij genofond. Karta geneticheskih rasstoyanij ot russkih Ryazanskoj oblasti po paneli 42 farmakogeneticheskih markerov vyyavila landshaft, rezko otlichnyj ot selektivno-nejtral'nogo landshafta predkovyh komponent. Naibolee blizki po farmakogeneticheskomu statusu k ryazanskim russkim populyacii Mordovii, Kaluzhskoj, Smolenskoj i Kostromskoj oblastej. Skhozhie po selektivno-nejtral'nym genomam ryazanskie i nizhegorodskie populyacii rezko razlichayutsya po farmakogeneticheskomu statusu. Eto podtverzhdaet neobhodimost' pricel'no issledovat' farmakogeneticheskie osobennosti populyacij Rossii.
Artesanato como ferramenta complementar ao ensino-aprendizagem de Ciências Morfológicas
Authors: Massari Catia Helena de Almeida Lima , Miglino Maria Angélica
Published: April 2022

Este artigo objetiva apresentar o artesanato, por meio da técnica de crochê, como ferramenta para o ensino-aprendizagem de Ciências Morfológicas. Os estudantes do primeiro ano do curso de graduação em Medicina Veterinária da Universidade Nove de Julho (Uninove) que já possuíam experiência prévia com crochê foram estimulados a criar modelos em lã ou linha, relacionando-os aos conteúdos das aulas teóricas e práticas de Morfofisiologia Animal. Foram produzidos amigurumis representativos de órgãos respiratórios, placentas e órgãos urinários. O referencial teórico da pesquisa foi estruturado nos seguintes pontos: questionamento sobre a possibilidade de se aprender Anatomia fora do laboratório; relação simultânea da Anatomia com a Ciência e a Arte; efeitos de métodos complementares de ensino no desenvolvimento processual e técnico dos alunos e no desenvolvimento cognitivo desses discentes; e paradigma construtivista aplicado ao ensino superior na área da saúde e educação inclusiva de membros da família. Os resultados alcançados reforçam que a melhor maneira de ensinar e aprender Ciências Morfológicas é por meio da combinação de recursos pedagógicos que se complementem, em especial nesses tempos de enfrentamento da covid‐19, quando as aulas em laboratórios foram substituídas por práticas adaptadas em prol do isolamento social. Esta pesquisa, de natureza exploratória, certamente permitiu refletir acerca de “como” ensinar Anatomia de forma alternativa e possibilitar um maior envolvimento dos estudantes no processo de aprendizagem, em tempos de ensino remoto, com base em uma perspectiva construtivista. A ideia construtivista permitiu a inclusão da confecção dos amigurumis para fins de avaliação da aprendizagem em Anatomia, uma vez que os estudantes não foram julgados somente com base em um conhecimento específico, mas, sim, a partir de suas capacidades em resolver o problema da criação das peças anatômicas em domicílio com uma solução viável. Concluiu-se que é possível a criação de modelos sintéticos em crochê de relativa semelhança às peças anatômicas originais. Por fim, o impacto desta pesquisa está no fato de os amigurumis terem sido desenvolvidos com materiais de fácil acesso, textura macia e baixo custo, sendo uma técnica de artesanato em potencial para ser aplicada ao ensino de Ciências Morfológicas.
Germany's migration policy and its significance for national border services
Authors: Filippov S. O. , Mota A. F. , Petrechenko S. A.
Published: April 2022

The scientific article analyzes migration processes and approaches to solving migration problems in Germany, as well as uses the experience of German migration policy in the activities of national border services. This process involves the study of the experience of neighboring countries, in particular Germany, where the intensity of migration processes is higher than in Ukraine, and accumulated more thorough and larger material for scientific analysis. The purpose of the study is to study the policy of Germany through the prism of the significance of these processes for the national border services of Ukraine. The outlined goal led to the formulation and solution of the following tasks: substantiate the main directions and theoretical and methodological approaches to the study of migration processes; to investigate the legal framework of state immigration policy; to evaluate the effectiveness of the adoption of the German migration policy by the national border services of Ukraine. The research methodology is based on the principles of systematization and scientificity. The scientific novelty of the obtained results is determined by the relevance of the researched topic, as well as the attempt to analyze the process of changes in approaches and directions of German migration policy, evaluate it at the present stage and explore prospects for its further development. As a result of the studyGermany's experience in shaping and improving the principles of migration policy can serve as an example for Ukraine, a country of origin, transit and destination of migrants.
The features of mediation in the criminal proceedings of Ukraine
Authors: Dmitrenko A. A. , Mazur M. R.
Published: April 2022

Resolving a criminal conflict through dialogue, taking into account the interests of both its parties, namely the victim and the suspect/accused, correcting the perpetrator of the corresponding criminal offence, as well as reducing the number of re-offenders – all are the real results of restorative justice.

One of the most common forms of restorative justice is mediation in the criminal proceedings. The introduction of mediation in Ukraine today is one of the urgent areas of reforming the system of citizens' access to fair justice.

What is mediation and what is its legal regulation? What are the features of the use of mediation in the criminal proceedings? The purpose of this scientific article is to clarify the above issues.

The article reveals the concept of mediation in the criminal proceedings. The current legislation, the Draft Law of Ukraine «On Mediation» as well as international legal acts regulating mediation issues in the criminal proceedings are analyzed.

The article also highlights the features of mediation in the criminal proceedings, reveal their essence. Particular attention is paid to the peculiarity of the subject composition, gravity and type of the criminal offense as one of the criteria for the application of the mediation procedure or its impossibility.

Modern Ukrainian legislation is known to provide sufficient prerequisites for the possibility of reconciliation between the victim and the offender, and hence for the application of restorative justice programs, including mediation. The legal institution with which mediation is often compared, and sometimes equated, is a reconciliation agreement between the victim and the suspect/accused. Within the article, the authors present their own vision of the correlation between the abovementioned legal institutions.

Consequently, the article states the existence of all prerequisites for the introduction of the institution of mediation in the criminal proceedings as well as the necessity of its enshrinement at the legislative level.
Development of measures to manage the liquidity and solvency of the enterprise
Authors: Seryozhkin S. O.
Published: April 2022

The article considers the possibility of making managerial decisions to achieve targets based on the analysis of the financial condition. The author, based on the analysis of the financial condition of the organization, assessing the importance of the liquidity and solvency of the enterprise and its positive impact on the achievement of production plans, determines the directions of a qualitative assessment of the current situation, the possibility of timely identification of resource management problems, including the effectiveness of their use and placement. The stability of the financial condition and its stability depend on the results of financial activity. As a result of the use of forecasting methods, a forecast of the values of liquidity coefficients is presented on the example of LLC «Techprogress».
Development of river рassenger transportation in the northern regions of the country
Authors: Yanchenko A. Yu. , Bigvava D. G.
Published: April 2022

Passenger transportation by river vessels plays an important role for the mobility of the population, especially in remote areas. Considering the social significance of river transport the state provides it with comprehensive support. State support measures include the development of waterway infrastructure and subsidizing river ports, especially in the northern regions of the country.
"Mental Health Problems in Abused Institutionalised Serbian Adolescents and Their Use of Social and Mental Health Services"
Authors:   ", KOVAČEVIĆ Svetlana I. ,   University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychiatry and Psychological Medicine.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia.", ŠOBOT Valentina ,   "University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychology.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia.", VEJNOVIĆ Ana M. ,   "University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychiatry and Psychological Medicine.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia. ", KNEŽEVIĆ Vladimir ,   "University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychiatry and Psychological Medicine.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia. ", MILATOVIĆ Jovan ,   "University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychiatry and Psychological Medicine.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia. ", ŠEGAN Darja ,   "University of Novi Sad, Faculty of Medicine Novi Sad, Department of Psychiatry and Psychological Medicine.  Clinic of psychiatry, Clinical center of Vojvodina, Novi Sad, Serbia. "
Published: April 2022

"The aim of the study was to determine the frequency of various forms of maltreatment in adolescents without parental care, their mental health problems and treatment needs. Sixty examinees of both genders, aged 12-18, were divided in two groups: abused group (adolescent without parental care in an institutional setting) and control group (general population). The presence/absence of registered abuse/neglect by official social services were the criterion for classifying respondents into groups. The general questionnaire, Childhood Trauma Questionnaire and Youth Self Report were used. 46.67% of adolescents were neglected, 40% of them suffered several types of abuse, 10% were physically abused, 3.33% were emotionally abused, and no adolescent was sexually abused. 16.6% of cases of sexual abuse in the abused group as well as milder forms of maltreatment in the control group were registered by self-reported retrospective measures, which are not part of official registers. Delinquency, aggressive behavior and somatic complaints are significantly more prominent in the abused group compared to the control group. 86% of adolescents used some form of support and counseling from professionals, 56.6% were included in psychiatric treatment, and only 36.6% in psychotherapy. Mental health problems in abused adolescents without parental care indicates the specific needs for psychotherapy and psychiatric treatment."
SOFT MAGNETIC NANOCRYSTALLINE Ni-Fe-X-Y AND MeFe₂O₄ POWDERS OBTAINED BY MECHANOSYNTHESIS
Authors: CHICINAȘ I. , POPA F. , NEAMȚU B.V. , MARINCA T.F. , ISNARD O. , POP V.
Published: April 2022

The soft magnetic nanocrystalline powders, alloys (Ni3Fe, 79Ni16Fe5Mo, 77Ni14Fe5Cu4Mo, wt. %) and zinc ferrite, were obtained by dry and wet mechanical alloying and reactive milling, followed by different heat treatments. The powders were characterised by X-ray diffraction, scanning electron microscopy, X-ray microanalysis, differential scanning calorimetry, thermomagnetic and magnetic measurements. The X-ray diffraction shown the progressive new phases formation. The crystallite size is between 18-7 nm depending on materials and milling conditions. The particle size is smaller for wet-mechanical alloying comparing with dry-milling. The thermomagnetic measurement shown the Curie temperature of the alloys. The spontaneous magnetisation of the wet-milled and annealed samples is higher than of the molten alloys.
Plonowanie i jakość wybranych gatunków i odmian pszenicy makaronowej. Cz. I. Plonowanie
Authors: Rachoń Leszek , Bobryk-Mamczarz Aneta , Kiełtyka-Dadasiewicz Anna , Woźniak Andrzej , Stojek Zbigniew , Zajdel-Stępień Paulina
Published: April 2022

Celem przeprowadzonych badań była analiza plonowania i elementów struktury plonu czterech odmian pszenicy ozimej – trzech odmian pszenicy zwyczajnej (Triticum aestivum ssp. vulgare): ‘Laudis’, ‘Patinas’ i ‘Danubius’ i jednej odmiany pszenicy twardej (Triticum durum Desf.) – ‘Lupidur’ – oraz czterech odmian pszenicy jarej – dwóch odmian pszenicy zwyczajnej (Triticum aestivum ssp. vulgare): ‘Nawra’ i ‘Telimena’ i dwóch odmian pszenicy twardej (Triticum durum Desf.): ‘Haristide’ i ‘Floradur’ – uprawianych w systemie rolnictwa konwencjonalnego. Doświadczenie polowe przeprowadzono w latach 2018–2021 w gospodarstwie rolnym w Niedrzwicy Dużej w województwie lubelskim. Warunki uprawy i zabiegi agrotechniczne były jednakowe dla wszystkich gatunków/odmian w kolejnych latach badania. Wyżej plonowały odmiany pszenicy zwyczajnej w porównaniu z odmianami pszenicy Triticum durum Desf., ponadto formy ozime prezentowały wyższy plon niż jare w przypadku obu gatunków. Wykazano odmienne plonowanie porównywanych gatunków w latach badań, szczególnie dla form jarych. W okresach zwiększonych niedoborów wody plon pszenicy durum nie różnił się istotnie od pszenicy zwyczajnej. W latach o bardziej optymalnym rozkładzie opadów plon pszenicy zwyczajnej był wyższy od 18,4% do 28,7%.
Plonowanie i jakość wybranych gatunków i odmian pszenicy makaronowej. Cz. II. Wartość technologiczna ziarna
Authors: Bobryk-Mamczarz Aneta , Rachoń Leszek , Kiełtyka-Dadasiewicz Anna , Szydłowska-Tutaj Magdalena , Lewko Piotr , Woźniak Andrzej
Published: April 2022

Celem pracy była ocena parametrów jakościowych ziarna czterech odmian pszenicy ozimej – trzech odmian pszenicy zwyczajnej (Triticum aestivum ssp. vulgare): ‘Laudis’, ‘Patinas’ i ‘Danubius’, a także jednej odmiany pszenicy durum (Triticum durum Desf.) – ‘Lupidur’ oraz czterech odmian pszenicy jarej – dwóch odmian pszenicy zwyczajnej (Triticum aestivum ssp. vulgare): ‘Nawra’ i ‘Telimena’ oraz dwóch odmian pszenicy durum (Triticum durum Desf. – ‘Haristide’ i ‘Floradur’) uprawianych w systemie rolnictwa konwencjonalnego. Doświadczenie przeprowadzono w latach 2018–2021 na terenie gospodarstwa rolnego w Niedrzwicy Dużej (woj. lubelskie). Warunki siedliska oraz zabiegi agrotechniczne były jednakowe dla wszystkich gatunków/odmian w kolejnych latach. W ziarnie oznaczono parametry charakteryzujące wartość technologiczną ziarna: masę tysiąca ziaren (MTZ), gęstość w stanie zsypnym, wyrównanie ziaren, zawartość białka, wydajność i jakość glutenu mokrego (rozpływalność), a także szklistość bielma. Wyższą masę tysiąca ziaren oraz wyrównanie odnotowano w przypadku odmian pszenicy zwyczajnej, z kolei odmiany pszenicy durum charakteryzowały się lepszym kompleksem białkowym (wyższą szklistością ziarna, wyższą zawartością białka i wydajnością glutenu mokrego oraz niższą rozpływalnością). Badane gatunki (odmiany), pod względem parametrów jakościowych, wykazały przydatność do produkcji makaronu. Odnotowane na niższym poziomie wyróżniki jakości surowca badanych odmian to: niższe wyrównanie ziarna odmiany ‘Haristide’ i szklistość ziarna odmiany ‘Laudis’ i podwyższona rozpływalność glutenu w przypadku odmiany ‘Patinas’.
Potensi Micro RNA (MiRNA) 499 sebagai Modalitas Multifungsi dan Mutakhir dalam Deteksi Dini Infark Miokard Akut
Authors: Suksmarini Pramita Widya , Dewi Putu Mela , Oktavian Hearty Indah
Published: April 2022

ABSTRACT

BACKGROUND: Acute myocardial infarction is a defective condition of cardiomyocytes due to ischemia resulting from blockage of the coronary arteries. Being one of the leading causes of death in the world, it needs an effective and accurate biomarker to diagnose so as to reduce the number of deaths from acute myocardial infarction. DISCUSSION: MicroRNA (miRNA) is a noncoding RNA molecule, consisting of 20-25 nucleotides. One of them is miRNA-499 which has been known as specific miR on heart muscle damage and also has a sensitivity of 78%, specificity 82%, and AUC 91% and can detect acute myocardial infarction in less than 1 hour. This suggests that miRNA-499 has potential in the management of acute myocardial infarction. CONCLUSION: MiRNA-499 has potential in the diagnosis of acute myocardial infarction.
PENTHOXYFILLINE SEBAGAI TERAPI KOMPLEMENTER CHRONIC KIDNEY DISEASE
Authors: Widianantara I Made , Dewi Ni Nyoman Gita Kharisma , Purwaningrum Ni Made Ari
Published: April 2022

Chronic kidney disease (CKD) was the 18th most common death cause annually, that often associated with elderly, diabetes, hypertension, obesity, and cardiovascular disease. CKD treatment that available now deemed less effective because it only postpone the progression od the disease. Pentoxyfilline (PTX) was one of treatment that can be used as complementary therapy in CKD. PTX can deliver renoprotective effect. Also, it can resolve proteinuria problem in patient with diabetic neuropathy. Therefore, PTX can be used as complementary therapy in patient with CKD
POTENSI miRNA SEBAGAI ALAT DIAGNOSTIK POLIP KOLON: SEBUAH TINJAUAN PUSTAKA
Authors: Jusni Louis Fabio Jonathan , Adiwardhana Jason , Kadharmestan Maxmillion Budiman
Published: April 2022

Pendahuluan: Polip kolon adalah pertumbuhan massa yang khas di dalam lumen kolon serta prekursor utama dalam perkembangan kanker kolorektal. Modalitas diagnostik yang menjanjikan seperti miRNA dapat digunakan untuk menilai perkembangan tersebut. Bukti dari berbagai studi menyatakan bahwa disregulasi dari fungsi miRNA menandakan adanya sebuah perubahan patologis terkait polip kolon. Tujuan: Tinjuan pustaka ini memberikan gambaran mengenai kemampuan miRNA dalam mendiagnosis keberadaan polip kolon serta mengidentifikasi kesenjangan pengetahuan yang ada untuk pembelajaran lebih dalam. Metode: Sebuah tinjauan berdasarkan Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) dilakukan menggunakan data dari database Pubmed, Science Direct, dan Proquest. Hasil: Sebanyak lima jurnal melaporkan ketepatan diagnostic miRNA dalam membedakan polip adenoma dengan normal, polip adenoma dengan polip hiperplastik, adenoma/polip sessile serrated dengan polip hiperplastik, dan polip kolon dengan kanker kolorektal. Simpulan: miRNA berpotensi menjadi sebuah biomarker yang sesuai untuk mendeteksi polip kolon. Dibutuhkan studi diagnostik lebih lanjut terhadap miRNA, terutama signifikansinya dalam ranah klinis.
Pemberdayaan Desa Adat dan Dokter Keluarga pada Aplikasi Telemedicine untuk Mengurangi Kejadian Covid-19 di Bali
Authors: Winda Astiti Vingky , Ristiani Ni Ketut , Gita Widyaswari I Gusti Ayu , Wiwiek Indrayani Agung
Published: April 2022

Abstract

Introduction: The prevalence of COVID-19 in Indonesia has increase especially in March to September 2020. One of the provinces affected by COVID-19 is Bali. This pandemic of COVID-19 makes the Bali’s local government publish various policies to reduce the prevalence of COVID-19. Traditional and religious leaders, youth leaders, political figures, and all elements of society in Bali has unite and more discipline to implementing the COVID-19 prevention protocol. To reduce the prevalence of COVID-19 in Bali, it is also needing to provide educate and give accurate information for the people of Bali. One of the solutions is to apply the concept of a family doctor, but as we see the pandemic situation, the whole society should apply physical distance for the prevention to COVID-19. Because of that, online health applications can be the effective solution to optimize health services, as the example is telemedicine.

Discussion: The use of telemedicine is the one of solution for doctors and Bali’s people to reduce the prevalence of COVID-19 by maintaining distance and providing personal care services by online. The concept of this program is to create the educate applications and online consultations, and collaborating with Bali’s traditional villages to ask about the number of families that can access the internet, and for helping to optimize the distribution of services evenly. For the effective delivery of information about COVID-19 in Bali, the family doctor can collaborate with Bali’s traditional villages.

Conclusion: According to research, family doctors play a very important role in the continuity of the patient's relationship with the doctor. By using telemedicine, we can do a prevention and educate people about the pandemic of COVID-19.

Keywords: COVID-19, doctor family, Bali’s traditional village, telemedicine, online application
Gambaran pencarian identitas agama remaja dengan orang tua beda agama di Bali
Authors: Priskila Donna , Widiasavitri Putu Nugrahaeni , Widiasavitri Putu Nugrahaeni
Published: April 2022

Perkawinan antar individu yang berbeda agama masih dan akan terus terjadi sebagai akibat interaksi sosial antar warga negara Indonesia. Tujuan sebuah perkawinan salah satunya adalah untuk melanjutkan keturunan. Anak yang lahir dari pasangan yang berbeda agama akan menghadapi berbagai permasalahan salah satunya adalah penentuan identitas agama. Penelitian ini menggambarkan proses pencarian identitas agama pada remaja dengan orangtua beda agama untuk membantu memahami proses tersebut terlebih dalam lingkup masyarakat Bali. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan fenomenologi. Pengambilan data dilakukan melalui in depth interview dan observasi pada lima  responden penelitian. Data kemudian dianalisis dengan theoretical coding. Hasil penelitian menunjukkan terdapat beberapa keadaan yang dialami oleh remaja dengan orangtua beda agama yang tidak dihadapi oleh remaja dengan orangtua yang memiliki agama yang sama. Keadaan tersebut dibagi menjadi dua bagian yaitu keadaan positif yaitu perasaan bangga akan perbedaan agama dalam keluarga remaja, yang kemudian membuat remaja merasa keluarganya merupakan keluarga yang istimewa, dan keadaan negatif yaitu remaja mengalami konflik terkait dengan prioritas menjalankan kegiatan agama yang membuat keluarga remaja menjadi tidak harmonis. Hasil berikutnya adalah faktor yang memengaruhi pemilihan agama yang dilakukan oleh remaja dibagi menjadi dua yaitu faktor internal yaitu keyakinan terhadap agama dan faktor eksternal yaitu ada tidaknya pembimbing dan role model. Remaja dalam penelitian ini juga sudah melakukan eksplorasi dan komitmen namun belum maksimal.
Financial statements of public sector organizations: The current status
Authors: ARBATSKAYA Tat'yana G.
Published: April 2022

Subject. This article discusses the issues of emergence and development of a new type of reporting, focused on meeting the information needs of various groups of users, and the establishment of new rules for the formation and disclosure of reporting indicators.
Objectives. The article aims to reveal the features of the regulation of accounting (financial) statements of public sector organizations at the present stage in order to develop an original classification of reporting in the face of changing user requests.
Methods. For the study, I used the methods of comparative analysis and classification.
Results. The article describes the features of legislative and legal regulation of accounting statements of public sector organizations. It proposes a classification of types of accounting statements of public sector organizations on various grounds. This helps to better understand the essence, purpose and relationship of various types of reporting, as well as determine the logic and trends of their development.
Conclusions and Relevance. The article concludes about the adaptation of the accounting and reporting system of public sector organizations to modern approaches to public finance management and development in accordance with the International Public Sector Accounting Standards (IPSAS). The results obtained can be used for further development of regulation of accounting (financial) statements of public sector organizations.
Estrategia de Marketing de Sostenibilidad en las empresas de México
Authors: Morales-González Maria G. , Ayup-González Jannett , Huerta-Zavala Pilar A.
Published: April 2022

Para reducir la brecha en la literatura de marketing de sostenibilidad, la presente investigación tiene como objetivo identificar las estrategias de marketing de sostenibilidad (MS) en las empresas que reportan sus informes de sostenibilidad en México. El análisis empírico utilizó datos de 47 empresas de varios sectores que cotizan en la Bolsa Mexicana de Valores (BMV) y compañías publicadas en la base de datos del Global Reporting Initiative (GRI). Mediante el análisis de contenido y el análisis de conglomerados se identificó que las compañías, atendiendo a los stakeholders de su cadena de valor: suministro, producción y distribución, están adoptando estrategias de marketing de sostenibilidad (MS). Sin embargo, la mayoría de ellas están en una etapa de adopción, enfocando sus esfuerzos en implementar prácticas de sostenibilidad en sus actividades de suministro y producción dejando la distribución como un área de oportunidad. Esta investigación se basa en empresas de un país de economía emergente, contribuye como una aproximación al fenómeno de sostenibilidad en marketing con datos directos obtenidos de sus informes publicados. Estudios futuros podrían comparar entre empresas con países desarrollados y en desarrollo.
Probabilistic-deterministic approach to calculating the fire risk caused by the impact of a radiant heat flow from the front of the independent massive crown wild fire on a building
Authors:   State Fire Academy of EMERCOM of Russia, PUZACH S.V. , MALAMUT O.Yu. ,   State Fire Academy of EMERCOM of Russia
Published: April 2022

Purpose. The purpose of the article is to create a mathematical model for calculating the fire risk caused by the impact of a radiant heat flux from the front of an independent crown wild fire on the combustible structures of a residential building. A combined calculation method has been developed that combines deterministic and probabilistic approaches. The combination of the above mentioned approaches is due to the fact that the probabilistic approach does not take into account the specific mechanism of the impact of a wild fire on the structure of a building, while the deterministic approach does not take into consideration the probability of a fire starting ABSTRACT and developing, as well as the timeliness of fire units response for fire extinguishing. Methods. The study uses theoretical methods of heat conduction and radiant heat transfer, wild fire statistics analysis, and fire risk theory. Findings. In the deterministic part of the method to calculate the temperature of the irradiated surface of the building structure, a one-dimensional non-stationary heat conduction equation is used, the boundary condition for which is determined by solving the equation of the radiant heat transfer between the wild fire front and the building. The calculated wood (pine) ignition time is compared with experimental data. The agreement between the calculation and experiment is satisfactory. The formula for calculating the fire risk for a residential building resulted from the impact of the radiant heat flux from the front of a wild fire is proposed. The above-mentioned formula takes into account the frequency of crown wild fires occurrence, the probability of ignition of combustible structures of the building when no firefighting measures are taken, as well as the probability of the active and passive fire prevention measures effectiveness. An example of fire risk calculation is presented when constructing a mineralized line, whose increase in width will reduce the fire risk by 1 000 times. Research application field. The results of the study can be applied in the development of fire prevention measures aimed at protecting communities against wild fires impact. Conclusions. The developed probabilistic-deterministic mathematical model for calculating the impact of a radiant heat flux falling from the front of an independent crown wild fire on the combustible structures of a residential building makes it possible to assess the fire risk for a building, considering specific meteorological conditions, pyrological and geometric (tree height, etc.) characteristics of the woodland, the distance from the building to the edge of the forest, as well as fire prevention measures implementation.
Support model and algorithms for managing, warning and informing population in case of emergency situations and fires at the municipal level
Authors:   State Fire Academy of EMERCOM of Russia, RAZHNIKOV S.V. , BUTUZOV S.Yu. ,   State Fire Academy of EMERCOM of Russia
Published: April 2022

Purpose. The relevance of the article is in the need to solve the problem of warning the population about fires and emergencies on a timely basis, assessing and improving the efficiency of the warning system with the use of mathematical tools and simulation. The work is aimed at developing a model and algorithms to support population warning management at the municipal level. Methods. The methods of system and regression analyses and the theory of active systems are used to decompose the population warning system, identify areas of concern and propose options to solve the problem of timely population warning. Findings. For the successful implementation of the ways and directions to solve the problematic issues identified in the course of the study, the authors have developed a tree of goals for the process of developing the model and algorithms to support the population warning management in case of fires and emergencies at the municipal level. Research application field. The study has made it possible to develop the model and algorithms for population warning management support in case of fires and emergencies at the municipal level at the stage of predicting possible destructive events. If the predicted boundary parameters are greater than or equal to the criteria characterizing the occurrence of an emergency, it is advisable not to wait for a decision to start warning systems, but to start the population warning system individually. Conclusions. The paper proposes a formalized simulation model for population warning management support in case of fires and emergencies using the tools of information and analytical support for officials of the commission for preventing and eliminating emergencies and ensuring fire safety at the municipal level. Using the model makes it possible to reduce the warning time by 20%, thereby minimizing the risks of destructive events. With the help of the developed models and algorithms, it is possible to train decision-makers to perform duties in case of forest and landscape fires, as well as in case of natural and manmade disasters.
Block Copolymer Giant Unilamellar Vesicles for High-Throughput Screening
Authors: Heuberger Lukas , Palivan Cornelia
Published: April 2022

Bottom-up synthetic cells offer the potential to study cellular processes with reduced complexity. Giant unilamellar vesicles (GUVs) can mimic cells in their morphological characteristics because their architecture is precisely controllable. We propose a block copolymer-based GUV system that can be used for high-throughput screening. Through droplet microfluidic methods, we produce double emulsions that then serve as templates for GUVs with adjustable inner, polymer membrane, and outer composition. Using flow cytometry, we are able to analyze tens of thousands of GUVs in a short amount of time, enabling their use for screening assays.
The Separation Power of Highly Porous 3D Nanofiber Sponges
Authors: Risch Patricia , Adlhart Christian
Published: April 2022

Sponges formed by the self-assembly of nanofiber building blocks are versatile materials used in various fields such as filtration, thermal insulation, scaffolding or sound absorption. Their potential seems to be constantly expanding given the variety of possible fiber materials, from bio-based to fossil polymers to inorganic nanofibers. In general, nanofiber sponges – also called nanofiber aerogels – are flexible, have low density, and a large specific surface area thanks to their tunable open-porous nanofiber based architecture. The latter property makes nanofiber sponges an interesting material for separation problems, as recently demonstrated for a variety of mixtures such as aerosols, emulsions, dispersions, solutions or two-phase systems. Due to their highly porous structure, they generally exhibit high filtration efficiency, flow rate and capacity. This article reviews the state of the art in the application of 3D nanofiber sponges for the different classes of mixtures. We will discuss on a mechanistic basis why nanofiber sponges are particularly well suited for separation applications. Finally, their performance in terms of efficiency, flow rate, capacity and regeneration will be compared to other fiber-based filter media.
Conical shape fluctuations determine the rate of ion-evaporation and the emitted cluster-size distribution from multiple-charged droplets
Authors: Kwan Victor , Consta Styliani
Published: April 2022

The ion-evaporation mechanism (IEM) is perceived to be a major pathway for disintegration of multi-ion charged droplets found in atmospheric and sprayed aerosols. However, the precise mechanism of IEM and the effect of the nature of the ions in the emitted cluster-size distribution have not yet been established despite its broad use in mass spectrometry and atmospheric chemistry over past half century. Here we present a systematic study of the emitted ion-cluster distribution in relation to their spatial distribution in the parent droplet using atomistic modeling. It is found that in the parent droplet, multiple kosmotropic and weakly polarizable chaotropic ions (Cs+) are buried deeper within the droplet than polarizable chaotropic ions (Cl-, I-). This differentiation in the ion location is only captured by a polarizable model. It is demonstrated that the emitted cluster-size distribution is determined by dynamic conical deformations and not by the equilibrium ion-depth within the parent droplet as the IEM models assume. Critical factors that determine the cluster-size distribution such as the charge sign asymmetry that have not been considered in models and in experiments are presented. We argue that the existing IEM analytical models do not establish a clear difference between IEM and Rayleigh fission. We propose a shift in the existing view for IEM from the equilibrium properties of the parent droplet to the chemistry in the conical shape fluctuations that serve as the centers for ion-emission. Consequently, chemistry in the conical fluctuations may also be a key element to explain charge states of macromolecules in mass spectrometry and may have potential applications in catalysis due to the electric field in the conical region.
Glycidyl Silanes Enable Regioselective Hydrosilylation of Internal Propargyl Alcohols and Direct Transformation into Activated Silanes for Further Chemical Transformation
Authors: Sugawara Akihiro , Koremura Soya , Sasano Yusuke , Kikuchi Haruhisa
Published: April 2022

Herein, we develop glycidyl silanes to facilitate highly regioselective hydrosilylation of internal propargyl alcohols, the products of which can in turn be converted to synthetically useful fluorosilanes for further chemical transfor-mations under mild conditions. Structure–selectivity studies and density functional theory calculations are consistent with high regioselectivity arising from a critical intermolecular hydrogen bond between the glycidyl and propargylic hydroxy groups. A broad substrate scope illustrates the generality of this reaction to form beta-E silylalkenes. Treatment of the beta-E silylalkenes with a fluoride salt induces simultaneous removal of the glycidyl group and activation of the silane under mild conditions. The fluorosilane products can be converted into vinyl arene and ketone derivatives via Hiyama coupling and Tamao–Fleming oxidation reactions, respectively. The discovery that glycidyl silane improves hydrosilylation regioselectivity and is compatible with expedient silylalkene derivatization may prove applicable to a variety of similar alkyne hydrofunctionalization reactions.