bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Employee Involvement in Analytical Decision Making on Employee Creativity: A Case Study of Higher Education in Oman
Authors: Balushi Talal Al , Muslim Noor Awanis , Khudari Mohamed
Published: July 2024

To better prepare students for the workforce, Oman's private higher education sector is experiencing a transition to keep up with global trends and industry collaborations. This is with the goal of better-preparing students for the workforce. In a landscape currently defined by fierce competition, this underscores the importance of differentiating oneself from the competition. In the private higher education sector in Oman, this study aims to investigate the relationship between employee engagement, analytical decision-making, and employee innovation. Specifically, the study will focus on the private sector. The total number of questionnaire responses is 308, which is the final analysis. We can conclude that analytical decision-making acts as a mediator between employee involvement and creativity based on the facts that we have uncovered. To add insult to injury, each and every one of the ideas that were put out was discovered to be supported. The findings of this study contribute to a better knowledge of the creative potential of personnel working in the private higher education industry. Additionally, the findings provide suggestions for improvements to regulations that are currently in place.
Beyond Ethnic Dining Experience: The Humanizing Factor
Authors: Yuliantoro Nonot , Hermawan Asep , Antonio Ferdi
Published: July 2024

Ethnic restaurants play a crucial role in the hospitality industry as they preserve and bridge the rich cultural heritage of the past with the evolving demands of current and future customers. This study identified key elements that shape the dining experience, providing valuable new insights. This research aims to analyze the role of ethnic food authenticity and customer interaction as antecedents of the ethnic dining experience as well as their impact on customer delight in ethnic restaurants. This study is a quantitative survey utilizing cross-sectional data gathered through the purposive distribution of questionnaires. A total of 428 samples were collected from three types of ethnic restaurants, specifically those with Sundanese, Balinese, and Padang backgrounds. SmartPls was used for the statistical analysis, which followed the PLS-SEM method. The findings of the research confirmed that three hypotheses were supported (p-value < 0.05, CI 95%). The strongest influence was from customer interaction (0.465), followed closely by ethnic food authenticity (0.462). In terms of consumer experience, the ethnic dining experience demonstrated a strong mediating role and direct influence on customer delight (0.871). These results align with previous studies, indicating that customer delight can be predicted and explained adequately (R² = 0.759; Q²_predict = 0.696). These findings offer valuable insights for ethnic restaurant managers in their marketing efforts to retain customers and encourage repeat visits. Managers should also carefully consider the layout and spacing of tables to ensure customer comfort and facilitate interaction with dining companions. A limitation of this study is its focus on restaurants in major cities. To generalize the findings, future research should include samples from ethnic restaurants in tourist destinations where culinary tourism is significant.
Impact of Canvas LMS on Communication, Evaluation, and Performance in Islamic Culture Education: A Quantitative Study
Authors: AlJahsh Muhammad Ahmad Ibrahim , Ammary Omar Mahmoud Al , Ali Basel J. A.
Published: July 2024

This paper aims to assess the efficiency of the Canvas LMS in the teaching of Islamic Culture at Al Qasimia University, UAE. Employing a quantitative approach, the research surveyed 155 students engaged in Islamic Culture courses using Canvas LMS, focusing on three key areas: communication, student evaluation, and student achievement. The study outcomes show a positive effect of Canvas LMS on all the three aspects. The findings from the quantitative analysis reveal a positive relationship between the use of Canvas LMS and student-instructor communication, student evaluation, and students’ performance. These findings indicate that the platform has the capacity to expand the teaching of Islamic culture in the digital environment. The study also outlines recommendations including the need to improve the feedback system and accessability of stored lessons. Recommendations are made for the improvement of Canvas LMS in the context of Islamic cultural studies based on these findings. This research contributes meaningful findings to the existing research on e-learning in cultural and religious education and provides implications to the educators and administrators of similar educational institutions. The findings and recommendations of this study may be useful to other institutions with similar programs and contribute to the improvement of the field of digital education in cultural studies.
Unravelling the leadership styles used by head librarians in universities in Kenya
Authors: Hongo Henry , Kwanya Tom , Mwai Naomi , Kiplang’at Joseph
Published: July 2024

There is an ongoing debate about what makes a leader successful. Whereas multiple views are discernible from the literature, the factors that determine leadership styles are not adequately discussed. This paper explores the leadership styles head librarians in university libraries in Kenya use. It specifically explores the roles and qualities of head librarians as leaders in universities in Kenya. Further, it analyses the leadership styles they apply and their effectiveness in facilitating successful university library leadership. The paper also examines the influence of age, educational level, and gender of the head librarians on their leadership styles. The study was conducted using a mixed methods research approach in eight (8) public and four (4) private university libraries in Kenya. Quantitative data was collected from library staff and library users (staff and students) using questionnaires, while qualitative data was collected from head librarians using interviews. The findings reveal that head librarians oversee the strategic and operational functions of university libraries. To perform these roles effectively, head librarians need effective communication skills. They should also be visionary, inspiring, motivating, patient, consistent and firm. The findings also reveal that the most effective head librarians apply a democratic leadership style. It is also demonstrated that while there may be some association between gender and leadership styles, it is not strong enough to be considered statistically significant. It also emerged that having a higher level of education (PhD) significantly influences head librarians’ leadership styles compared to having a lower level of education (MSc). However, the association between age and leadership styles was not statistically significant.
The Role of the Regional National Crafts Council of East Nusa Tenggara Province in Empowering Woven Fabric Crafts Groups
Authors: BETI Fince Orita , PANDIE David B.W , KELEN Pius Bumi
Published: July 2024

This research aims to determine the role of the NTT Dekranasda in empowering woven fabric craft groups. This research uses a qualitative descriptive method with combined data collection techniques through interviews, observation, documentation and focus group discussions (FGD).
The results of the research show that Dekranasda NTT has played a role in empowering woven fabric craft groups, including Dekranasda NTT acting as a motivator in human development and institutional development, a communicator in business development and institutional development, and a dynamist in business development and institutional development. However, in carrying out its role, Dekranasda NTT experienced several obstacles, including limited capital to carry out woven fabric craft development activities again and obstacles faced by craft groups, namely lack of capital and raw materials in the weaving process, resulting in delays in every activity. Craft groups still need to issue business permits and copyrights for each of their businesses and weavings; this could be a waste of money for anyone who is not responsible for plagiarizing the weaving that the craft group has weaved.
Mechanism and Potential Therapeutic Strategies Based on PRMT5 in Chemotherapy-Induced Drug Resistance in Non-Small Cell Lung Cancer
Authors: Zhang Zheng , Liu Yi
Published: July 2024

As a malignant tumor with high morbidity and mortality in the world, the treatment of non-small cell lung cancer is still facing great challenges. Although new breakthroughs have been made in recent years and great progress has been made in chemotherapy and targeted therapy, the five-year survival rate of most NSCLC patients is still at a low level. The emergence of drug resistance is one of the important factors affecting the therapeutic effect and survival rate of patients. PRMT5 (protein arginine methyltransferase 5), as a type II arginine methyltransferase, plays an important role in cancer cell proliferation, differentiation, apoptosis and tumorigenesis. At present, people pay more and more attention to the research on the mechanism of PRMT5 in tumor drug resistance. In this review, we summarize the mechanism of PRMT5 in chemotherapy resistance of non-small cell lung cancer and discuss potential strategies to avoid or overcome chemotherapy resistance.
An Evaluation of Cultural Symbolism of Selected Items on the Lomolehin Masquerade Costume
Authors: Adeyemo Peter Adewole
Published: July 2024

The masquerade culture is so significant and usually well celebrated annually among the Yoruba of South-western Nigeria that, just like their counterparts in the Eastern part and some areas in the former Middle Belt of the country, they cannot do without honouring their departed ancestors in costumed figures. This is a sequel to their strong belief in life after death and that these departed individuals have pivotal roles they play in the lives of the living. It is against this backdrop that the veneration of the dead via ancestral worship is taken seriously among the aforementioned ethnic groups. This paper, however, evaluates the cultural symbolism embedded in selected elements of the Lomolehin masquerade costume of Ogbomoso in Oyo State, offering insights into the rich cultural heritage and significance or even meaning of this traditional attire to determine their relevance in the masquerading tradition. A qualitative methodology was adopted using historical and descriptive approaches to analyze the cultural essence of the selected items, and collected data from the sampled population, using a purposive technique to exclude people that do not fit into the profile. By and large, the study articulates the nuances of the selected magical items on the Lomolehin masquerade costume and concludes that the items or amulets have dual functions in that they are both symbolic and aesthetic. However culturally, their symbolical values are more significant than the visual appeal and aesthetic sensibility the costume evokes. Hence, it is recommended that the potency of spiritual powers inherent in the various magical items on the costume such as Ado-Oyin and Arinu-Rode, among others, should be embraced, adapted and collaborated with relevant agencies to advance knowledge in technological studies to contain the diverse security challenges bedevilling the Nigerian space.
Los juicios políticos durante la Confederación Argentina. Debates y experiencias en el Congreso Nacional
Authors: Lanteri Ana Laura
Published: July 2024

El objetivo de este artículo es analizar las formas y sentidos en que el Congreso Nacional que sesionó en Paraná, capital de la Confederación Argentina, tramitó las solicitudes de juicio político. Interesa recuperar esta experiencia para aportar al conocimiento del proceso de conformación, funcionamiento y legitimación del sistema político durante esta etapa. Ya que al momento dichos juicios políticos no han sido considerados en detalle ni en forma conjunta como se propone. Pese a la singularidad de que entre 1853 y 1860 los gobernadores fueron sujetos a acusación, tanto en lo estipulado por la constitución nacional hasta la reforma de 1860 como en la mayoría de los casos atendidos. A la par, se pretende contribuir a la actual revisión acerca del protagonismo del poder legislativo en la edificación estatal decimonónica latinoamericana así como, subsidiariamente, a la historización del Derecho Parlamentario.
El Legado de Sócrates. La fidelidad al pensamiento
Authors: Martínez Hernández José
Published: July 2024

La figura de Sócrates es el misterio filosófico más destacado de la filosofía occidental. Las valoraciones sobre él son múltiples y diversas, los eruditos tampoco se ponen de acuerdo, pero es innegable su importancia como mito creado por Platón en sus diálogos. En ellos Sócrates encarna la filosofía como modo de vivir y de morir, el examen de uno mismo como cuidado del alma, la crítica de los prejuicios y las creencias infundadas y, sobre todo, la fidelidad al pensamiento, es decir la idea de que una vida sin pensar no es de veras humana. Su ejemplo continúa hoy más vivo que nunca en un mundo que se caracteriza, entre otras cosas, por la voluntad de no pensar.
Study on the electrodeposition of MoS2 on different electrode materials used as electrode catalysts for the electrochemical synthesis of ammonia from N2 and H2O
Authors: Pham Trung Quoc Anh , Tran Chi , Duong Kieu Anh , Hoang Thanh Ai  , Nguyen Thi Mo
Published: July 2024

Herein, MoS2 was deposited electrochemically on nickel foam (NF), copper foam (CuF) and carbon paper (CP). The samples  were characterized by XRD, SEM and were used as cathodes for the nitrogen reduction reaction in an acidic medium. NH4+ concentration was determined by the indophenol blue method. Both the density of the cathodic current and the NH4+ concentration achieved their highest values with MoS2 deposited on copper foam. However, nickel foam was determined to be a higher-performance electrode material, which showed highest NRR efficiency, 3,62%, probably due to its higher ECSA value.
Vanadium-doped TiO2 Adsorbent-Photocatalyst for Organic Dye Treatment
Authors: Nguyen Thi Thom , Nghiem Thi Thuong , Hoang Huu Hiep , Cao Hong Ha , Nguyen Vân-Anh
Published: July 2024

This study focuses on the synthesis of V-doped TiO2 materials using a modified polyol method to enhance their efficiency. The obtained materials were characterized by various methods such as XRD, EDX, FTIR, SEM, TEM-SAED, Raman, and UV-Vis DRS. The results indicated the crystalline anatase phase of TiO2, with spherical morphology and an average size of 30nm. The UV-DRS measurement demonstrated that doped materials have a lower bandgap than the pristine TiO2. The material possesses dual functionality, with adsorption capability and photocatalytic activity applied to treat organic dye contaminants. Evaluation of MB degradation under UV irradiation revealed an exceptional efficiency of up to 99% within a remarkably short duration of 30 minutes. Furthermore, the catalyst exhibited robust recovery efficiency exceeding 99% after 2 regeneration cycles and retention of approximately 80% after four cycles.
Su alcune serialità nella poesia francese contemporanea
Authors: Scotto Fabio ,   Università degli studi di Bergamo
Published: July 2024

L’articolo propone una riflessione sulla serialità della poesia francese contemporanea. Dopo avere mostrato come la stagione simbolista introduca la trangenericità formale che fa incamminare la poesia verso la prosa, individua nelle tipologie seriali legate alla titolazione dei testi e all’articolazione metrica e retorica del linguaggio, le peculiarità della contrainte assunta. Lo studio individua poi nell’opera di tre autori del Secondo Novecento alcune delle forme prevalenti di serialità. In Jacques Ancet si tratta di una serialità isostrofica, che propone frammenti isostrofici e isosillabici; in Alain Suied di una serialità poematica, basata sulla reiterazione anaforica, e in Christophe Tarkos di una serialità calligrammatica, che fonde parola e disegno attraverso un uso geometrico della pagina. Indipendentemente dalle differenze della forma espressiva, queste poetiche trovano un punto di contatto nella dimensione spazio-temporale del testo che agisce come un elemento unificante della voce poetica.
Supervisi Klinis untuk Meningkatkan Kemampuan Guru dalam Menyusun Naskah Soal Asesmen Madrasah
Authors: Saepuloh Asep
Published: July 2024

Penelitian ini bertujuan meningkatkan kemampuan guru dalam menyusun soal asesmen madrasah yang baik dan benar sesuai kaidah. Tujuan khususnya adalah mengidentifikasi kelemahan dalam tiga unsur penyusunan soal (materi, konstruksi, dan bahasa), menentukan unsur yang paling memerlukan penguatan, dan melakukan evaluasi untuk perbaikan. Penelitian dilakukan di MAS Terpadu Ar Rahman Nasol Ciamis. Supervisi klinis dilakukan untuk menilai pelaksanaan regulasi di lapangan dan menemukan kelebihan serta kekurangan. Hasil penelitian menunjukkan masih banyak kekeliruan dalam penyusunan soal, sehingga perlu pembimbingan dan pelatihan lebih lanjut.
Manajemen Pengawasan dan Evaluasi di Madrasah Aliyah
Authors: Saepuloh Asep
Published: July 2024

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen pengawasan dan evaluasi di lembaga pendidikan Islam, Untuk mengetahui lebih jauh tentang hal tersebut, penulis melakukan penelitian di Madrasah Aliyah Persis Sindangkasih Ciamis Metode yang digunakan pada penelitian ini adalah deskriptif kualitatif. Hasil penelitian ini adalah menggambarkan manajemen pengawasan dan evaluasi di Madrasah Aliyah Persis Sindangkasih, yang dilakukan oleh tiga komponen yaitu ketua yayasan, kepala madrasah dan pengawas madrasah dari kementerian agama. Ketua yayasan melakukan pengawasan terhadap sumber daya manusia, keuangan, kelengkapan sarana prasarana. Pengawasan kepala sekolah dilakukan terhadap tenaga pendidik dan tenaga kependidikan berupa pengawasan keterlaksanaan kegiatan belajar mengajar (KBM). Sementara pengawasan oleh pengawas madrasah adalah pengawasan akademik dan manajerial. Kesimpulan dari penelitian ini menguatkan bahwa manajemen pengawasan dan evaluasi mutlak diperlukan pada lembaga apapun, termasuk juga lembaga pendidikan Islam yang jadi objek penelitian penulis. Semakin efektif sistem menajemen pengawasan maka akan semakin terkontrol mutu dan kualitas lembaga. Sistem multi pengawasan akan menciptakan system kontrol yang lebih efektif dalam mengawal mutu kinerja. Hal tersebut dibuktikan melalui penelitian bahwa pengawasan proses pelayanan pedidikan oleh tiga komponen pengawas yaitu pengawasan dari ketua yayasan, kepala madrasah dan pengawas madrasah dari pemerintah dapat meningkatkan efektifitas pelayanan pendidikan oleh lembaga kepada steakholder yakni siswa dan orang tua.
Adoption of ChatGPT and other Artificial Intelligence among Physicians around the world: Barriers and the way-forward
Authors: Khan Dr. Muhammad Muneeb , Khan Dr. Muhammad Oneeb , Ibad Ur Rehman
Published: July 2024

Artificial Intelligence (AI) has emerged as a transformative force in modern society, revolutionizing various industries, including healthcare. ChatGPT, a language processing tool, has garnered significant attention for its ability to simulate human-like conversations and assist in a myriad of tasks. Despite its potential, the adoption of ChatGPT among physicians worldwide remains limited, particularly in regions like Asia, Latin America and Sub-Saharan Africa. This reluctance poses barriers to leveraging AI for novel diagnosis and treatment approaches, hindering progress in global healthcare. In this study, we explore the medical importance of AI, particularly ChatGPT, highlighting its potential to reduce medical errors and provide accurate healthcare information. However, concerns regarding bias, dependency, and plagiarism have surfaced, necessitating cautious integration and human oversight in its application. Recommendations include increasing awareness among physicians, implementing ethical guidelines, and utilizing AI-detecting software to mitigate risks. Furthermore, collaboration between international medical associations, policymakers, and governing bodies is essential to promoting AI adoption and ensuring its ethical use. While AI holds promise for advancing healthcare, its full potential hinges on overcoming current barriers and fostering a symbiotic relationship between technology and human expertise. Future research must address lingering uncertainties and ethical considerations to realize the transformative impact of AI in medicine.
In vitro Propagation of Citrus aurantifolia and its Conservation in Pakistan
Authors: Momin Abdul , Naheed Rafia , Khan Wajahat , Shujaat Hira , Khan Muhammad Ghazanfar Javed
Published: July 2024

Citrus varieties are propagated by both asexual and sexual methods. Generally, rootstocks are propagated sexually through seeds, while most of the commercial varieties are propagated by various asexual methods such as grafting and budding. The technology called plant tissue culture is used for commercial production of plants that are microbe and virus free and to save germplasm of infrequent or threatened species of plants. Fast reproduction techniques have the potential to produce plants free of viruses. Likewise, traditional propagation methods are old, time consuming and are difficult. Tissue culture techniques are assumed for reliable commercial production of economically important plants. In present study shoot tips of Citrus aurantifolia were collected from the field of BCI, NARC. Different disinfectant (Ethanol and NaOCl) with the concentration ranging from 10 to 20 percent were used for culture establishment. Maximum survival percentage was observed in 10% NaOCl. After 5 weeks, established cultures were shifted to hormonal growth media (BAP, GA3 and NAA) at the concentration ranging from 0.1 to 0.8 mg/L. Our finding results that maximum phenotypic characters (plant height, number of leaves and number of shoots were observed on BAP at the concentration of 0.1 to 0.3 mg/L, while maximum number of roots were observed on NAA at the concentration of 0.5mg/L. In present study, for in vitro conservation different conservants like sorbitol and mannitol (10, 20 and 30 g/L) were used. Incubation of cultures was maintained at 21°C under the light intensity of 1000 lux. Old cultures of Citrus aurantifolia were shifted in conservant media. Overall, remarkable difference was observed. In present study mannitol at the concentration of (10, 20 and 30 g/L) showed slow growth after 35 days. In future the plants in conservation media will be used for further propagation and for growing them in fields.
The Power of Nutrition
Authors: Zubair Akmal , Akhtar Nasim , Iqra Gul Khuwaja  , Abdul Haseeb  , Jennifer Pham
Published: July 2024

Both the metabolic foundation of diabetes and the complications of the disease can result in significant losses of essential micronutrients. This review is a summary of the research that investigates the impact that type 2 diabetes has on the body's capacity to digest trace minerals, vitamins, and other nutrients. This review covers the micronutrient status, metabolic needs, and likely requirements for micronutrients in type 2 diabetics. Since vitamin D and type 2 diabetes have been the subject of extensive coverage elsewhere, we will not go into further detail about them here. Some of the less well-known micronutrients that were investigated include zinc, magnesium, chromium, copper, manganese, iron, selenium, and vanadium, as well as certain antioxidants and vitamins from the B group. Although there is still a great deal more research to be done in this field, it has been demonstrated that supplementing with micronutrients can have a positive impact on the control of glycemic levels. More research is needed to develop improved biomarkers of the status and requirements of micronutrients in type 2 diabetes. It can be challenging to determine how much micronutrient supplementation a person with type 2 diabetes should take in order to attain glucose homeostasis.
The Potential of Insulin Therapy in Improving Cardiovascular and Pulmonary Health for Diabetic Patients
Authors: Khan Haris , Ibrahim Dr. Muhammad , Dr. Shafiq Ur Rahman  , Mohsin Dr. Amna , Niazi Dr. Abban Anwar , Maryam Dr. Iqra
Published: July 2024

Aims: This study aimed to investigate the effects of diabetes on cardiac contractile proteins and assess the potential reversibility of these effects through insulin therapy, with a specific focus on the interconnectedness of cardiovascular and pulmonary health.
Methods: A prospective 9-month study involving 150 adults categorized into three groups, including diabetic individuals without insulin treatment, those with insulin treatment, and a control group. Comprehensive baseline assessments were conducted, and various measurements, including cardiac contractile proteins, glycemic control, heart function, and pulmonary health, were analyzed at regular intervals. Statistical analyses encompassed paired and independent t-tests, ANOVA, and regression analysis, utilizing SPSS software (version 23) with a significance threshold of p < 0.05.
Results: Both diabetic groups demonstrated improved glycemic control, with the Diabetic Insulin Group (DIG) experiencing a reduction in HbA1c levels from 8.3% to 7.9% and the Diabetic Group (DG) displaying a decrease in fasting blood glucose levels from 166.2 mg/dL to 158.4 mg/dL. DG showed enhanced ejection fraction, suggesting improved cardiac function, and a minor shortening of the QTc interval, indicating better electrical cardiac stability, potentially linked to enhanced pulmonary function. A noteworthy increase in actin levels was observed in DIG, signifying a potential reversal of cardiac protein changes with potential implications for pulmonary health.
Conclusion: This study underscores the significance of effective glycemic control and the potential of insulin therapy in preserving or restoring heart function in individuals with diabetes, emphasizing the need for comprehensive diabetes management in addressing and preventing cardiac issues. Pulmonary function tests indicated minimal changes in pulmonary health within the study's timeframe, suggesting limited impact during this period.
Investigating the impact of SGLT2 Inhibitors on Cardiovascular Outcomes in Patients with Type 2 Diabetes
Authors: Ahmad Hassaan , Saleem Sana , Tahiri Himayatulhaq , Nisar Sara , Ullah Safi , Bilal Musaddiq
Published: July 2024

Background: A major cardiovascular risk is associated with type 2 diabetes mellitus (T2DM), hence efficient treatment approaches are required to reduce negative effects. Beyond just controlling blood sugar, sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise as cardiovascular medicines.Methodology: March 2023–February 2024 saw the conduct of a retrospective cohort research at Hayatabad Medical Complex in Pakistan. The study included 58 patients with T2DM, assessing cardiovascular outcomes among those treated with and without SGLT2 inhibitors. Data on baseline characteristics, medication history, and cardiovascular events were analyzed, with multivariable regression to assess associations.Results: Out of the total of sixty-eight patients, thirty were using SGLT2 inhibitors. Compared to the group of non-SGLT2 inhibitors, the SGLT2 inhibitor group had a decreased occurrence of cardiovascular events (13.3% vs. 28.6%, p = 0.041). The study found a significant association between the reduction of cardiovascular risk and the usage of SGLT2 inhibitors (adjusted odds ratio: 0.41, 95% confidence interval: 0.18–0.92, p = 0.032) based on multivariable regression analysis.Conclusion: Consistent with previous research, our results show that SGLT2 inhibitors have beneficial effects on the cardiovascular system in people with type 2 diabetes. If they are a component of all-encompassing treatment plans for type 2 diabetics, SGLT2 inhibitors may even with research limitations enhance cardiovascular outcomes. Validating these results and delving further into the underlying processes will need prospective research.
Understanding Hernia's Repair, Techniques, Mesh Options, and Recurrence Rates in Abdominal Wall Surgery
Authors: Muhammad Umair  , Zaidi Syeda Farwa , Muhammad Usman Khan  , Mahnoor Naveed  , Sumbal Yaseen Wazir  , Lal Jawahir
Published: July 2024

Introduction: Hernia repair surgery is a common procedure with significant variations in techniques, mesh options, and recurrence rates. Understanding these factors is essential for optimizing patient outcomes.
Objective: This study aims to investigate hernia repair techniques, mesh options, and recurrence rates in abdominal wall surgery, providing insights to optimize patient outcomes and inform clinical decision-making.
Methodology: A retrospective cohort study was conducted at two renowned hospitals in Peshawar, Pakistan, with a sample size of 102, from April 2023 to March 2024. Data on surgical techniques, mesh options, postoperative complications, and hernia recurrence rates were collected from medical records. Chi-square tests were used for statistical analysis.
Results: A total of 102 patients were included in the study, with inguinal hernias being the most common (56.9%). Open tension-free repair was the predominant surgical approach (62.7%), and polypropylene mesh was the most commonly used (70.6%). Postoperative complications were observed in 19.6% of patients, with surgical site infection being the most frequent (11.8%). Hernia recurrence occurred in 13.7% of cases, with no significant association found between surgical approach and recurrence rates (p=0.632).
Conclusion: This study provides insights into hernia repair outcomes highlighting the prevalence of inguinal hernias, the predominance of open tension-free repair, and the challenges posed by postoperative complications and hernia recurrence. By addressing these challenges and embracing tailored surgical approaches, we can enhance patient care and improve surgical outcomes.
Association between obesity and risk of kidney stones: exploring the rule of life style factors
Authors: Anwar Ayesh , Hanif uz Zaman  , Haseeb Syed Abdul , Ahmad Hassaan , Awalrehman  , Khan Imran
Published: July 2024

Introduction: Kidney stones are a prevalent health concern, with obesity recognized as a significant risk factor. Understanding the interplay between obesity and lifestyle factors in stone formation is crucial. This study investigates this association, focusing on dietary habits, fluid intake, physical activity, and medication use.
Methods: A one-year prospective April 2023–March 2024 saw the conduct of a cohort study at the Pakistan Academy of Medical Sciences (PIMS) in Pakistan's Islamabad. 88 participants were enrolled, with baseline data including demographics, BMI, medical history, and lifestyle factors. Follow-up assessments monitored weight changes, urinary parameters, and kidney stone incidence. Multivariate regression analysis explored associations between obesity, lifestyle factors, and stone risk.
Results: Obese participants exhibited higher comorbidity prevalence and medication use. Over the study, obese participants gained 3.7 kg, while non-obese lost 1.5 kg. Obese individuals had elevated urinary calcium and oxalate, and lower citrate levels. Kidney stone incidence was 16.7% in obese and 9.5% in non-obese participants. Multivariate analysis identified obesity, high animal protein intake, and low fluid consumption as significant predictors of stone risk among obese individuals.
Conclusion: This study underscores the complex relationship between obesity, lifestyle factors, and kidney stone risk. Modifiable factors like dietary habits and fluid intake play crucial roles in stone formation. Insights from this research can inform targeted interventions to reduce stone burden and improve health outcomes in obese individuals.
The Impact of Regorafenib on Cardiac Function in Metastatic Colorectal Cancer Patients a Retrospective Cohort Study
Authors: Rizwan Muhammad , Yousuf Muhammad Hamza , Ur Rahman Shafiq , Ali Rizwan , Tahir Eisha Turazia , Pasha Rabbia
Published: July 2024

Introduction: Metastatic colorectal cancer (mCRC) poses significant clinical challenges, necessitating the exploration of novel treatment modalities. Regorafenib, a multi-kinase inhibitor, has emerged as a promising therapeutic option for refractory mCRC. However, concerns regarding its potential cardiotoxic effects warrant comprehensive evaluation of its impact on cardiac function parameters in this patient population.
Methods: The purpose of this retrospective cohort research was to find out how regorafenib affected cardiac function measures in patients with metastatic colorectal cancer (mCRC) at the Pakistan Institute of Medical Sciences (PIMS) in Islamabad. 78 adult patients in all, having histologically proven mCRC, who were treated with regorafenib between January 2023 and March 2024 were included in the analysis. Baseline characteristics, treatment details, cardiac function parameters, and incidence of cardiac events were retrospectively analyzed. Statistical analyses were performed to assess changes in cardiac function parameters and identify predictors of cardiac toxicity associated with regorafenib therapy.
Results: Following regorafenib therapy, there was a significant decrease in left ventricular ejection fraction (LVEF), alterations in diastolic function indices, and an incidence of clinically significant cardiac events (12%), including heart failure, arrhythmias, and myocardial infarction. Subgroup analyses identified older age, male sex, pre-existing hypertension, longer treatment duration, and higher cumulative doses of regorafenib as potential predictors of cardiac toxicity.
Conclusion: This study underscores the potential cardiotoxic effects of regorafenib in mCRC patients and highlights the importance of personalized cardiac monitoring and risk management strategies during treatment. Further research is warranted to validate these findings and inform evidence-based approaches to optimize the cardiovascular safety of regorafenib in clinical practice.
Toxicological Effects of Colloidal Silver Nanoparticles on Rat Health: Assessing Physiological, Hematological, Biochemical, and Behavioral Parameters
Authors: Rehman Roheena , Khanam Shehla , Khan Yumna , Hayat Faiza
Published: July 2024

Introduction: Nanotechnology, a rapidly evolving field, has introduced silver nanoparticles (AgNPs) as promising materials with diverse applications. Their unique properties have revolutionized industries, raising concerns about potential health implications. This study aims to comprehensively evaluate the toxicological effects of AgNPs on rat health through a multidimensional approach, encompassing physiological, hematological, biochemical, and behavioral assessments.
Methodology: Colloidal AgNPs with a minimum purity of 99.98% were synthesized using an inductive coupled plasma (ICP) method. Sixty male specific-pathogen-free (SPF) Wistar rats were exposed to low (10 μg/kg/day) and high (100 μg/kg/day) doses of AgNPs, alongside a control group. Throughout the exposure period, comprehensive assessments, including body weight changes, food intake, water consumption, hematological and biochemical parameters, and behavioral evaluations, were systematically conducted. The statistical analysis employed a combination of one-way ANOVA and Kruskal-Wallis tests for robust data interpretation.
Results: Rats exposed to low (10 μg/kg/day) and high (100 μg/kg/day) doses of AgNPs displayed no significant changes in food intake, water consumption, or blood parameters compared to the control group. However, a notable reduction in body weight was observed in the high-dose group, suggesting a potential dose-dependent impact. Biochemical analyses indicated no significant differences in liver and kidney function parameters for the low-dose group, but the high-dose group exhibited potential elevation in liver enzymes, necessitating further scrutiny. Behavioral assessments revealed no significant alterations in open-field behavior or cognitive function, indicating minimal impact on exploratory and cognitive abilities within the tested doses.
Conclusion: AgNPs demonstrated minimal impact on certain parameters, the high-dose group exhibited notable body weight reduction and potential liver enzyme alterations, warranting further investigation. Behavioral assessments indicated no significant cognitive effects. These findings emphasize the importance of continued research for informed regulatory decisions and the safe utilization of AgNPs in consumer products.
Role of Actinomyces species in oral Biofilm Formation and Dental Plaque-Related Diseases
Authors: Akbar Palwasha , Salahuddin Naima , Ahmad Zeeshan , Shah Syed Zeyad , Shah Fareeha , Maknoon Dure
Published: July 2024

Introduction: Actinomyces species play a major role in the development of oral biofilms and disorders associated with dental plaque. The purpose of this study was to look into their interactions, prevalence, and ability to form biofilms in dental plaque.
Methodology: Dental plaque samples from 78 participants in a six-month cross-sectional research at KCD Peshawar were examined for Actinomyces species. The microtiter plate test was used to measure the production of biofilms, and statistical analyses were performed to investigate the relationships between Actinomyces presence, plaque severity, and biofilm formation capacity.
Results: A total of 79.5% of samples contained Actinomyces species, with Actinomyces naeslundii being the most common (72.6%). Actinomyces was found to be significantly correlated with the severity of the plaque (χ² = 8.92, p = 0.012). In comparison to mild/moderate plaque (mean OD570 = 0.52, t(60) = 2.78, p = 0.007), isolates from severe plaque (mean OD570 = 0.61) formed more biofilms. Increased biofilm biomass was obtained through co-cultivation with Streptococcus mutans, particularly in combinations involving A. israelii and S. mutans.
Conclusion: Actinomyces species are important in the development and severity of dental plaque, with more severe cases being associated with higher biofilm-forming capacity. Their relationships to Streptococcus mutans increase the pathogenicity of biofilms. Actinomyces targeting may be able to reduce tooth plaque-related illnesses. Larger populations and biological reasons for successful interventions should be investigated in future studies.
The Relationship between Social Media Addiction and Depression among Medical Students of Peshawar
Authors: Maqsood Hafsa , Sami Sheema , Khan Nadia , Zaman Bushra , Abbasi Taskeen , Afreen Zainab , Dilawar Mehak
Published: July 2024

Background: Melancholy is one of the major fitness issues in modern society. WHO has found that melancholy is the most common reason for disability nowadays. It is a common and extreme mental disorder that affects someone's everyday activities and capabilities, consisting of questioning, falling asleep, eating, working, and analyzing. In our research, we want to show the connection between social media use and depression in medical students. . Research studies have shown that excessive use of social media affects students' mental health. Social media use can increase depression among users.
Objective: To determine if a relationship exists between social media and depression among medical students of Peshawar,
Methodology: A cross-sectional study was carried out among the students of private medical colleges in Hayatabad, Peshawar. An online questionnaire was designed using Google forms and was sent to the participants via WhatsApp. The questionnaire was filled out by 282 participants. Data analysis was done using SPSS version 20 and MS EXCEL was used to make graphs and figures.
Results: The age of participants was between 18 and 27 years. 56.7% were using social media for personal needs and interests, 10.6% were using it for educational purposes, and only 2.5% were using it for professional purposes. We found that 40.1% were using social media more than 10 times per day, 36.9% used it 2–5 times a day, and 5.7% used it only 7 (2.5%) out of 282 participants. According to the scale, 275 (97.5%), 275 (97.5%) have an addiction, and 275 (97.5%) have no addiction. 193 (68.4%) participants out of 282 were at risk of clinical depression, and 89 (31.6%) have no clinical depression.
Conclusion: According to this study, social media does not necessarily cause depression. It was concluded that depression may be due to other causes like stressful life, unemployment, family problems, and low socioeconomic status.
The Role of Early Diagnosis and Intervention in Improving Outcomes for Lung Cancer
Authors: Adil Saeed  , Faiz Muhammad  , Jawad Ahmad  , Haseeb Akhtar  , Muhammad Adeel  , Adnan Ahmad
Published: July 2024

Introduction : For lung cancer patients,  early diagnosis and treatments  are essential to battering outcomes. The  objective of this world is to compare early diagnosis vs late  diagnosis in terms of overall survival ,progression _free survival,  quality of life and adverse events associated to treatment.
Methodology: A Prospective cohort trial of  seventy_ eight  lung cancer patients was Conducted at Hayatabad Medical Complex  in Peshawar  from December 2021 to March 2024. 39 patients had early diagnosis (n=39) while  39 received late  diagnosis(n=39) . Low_ dose Computed Tomography (DCT)  screening and prompt  symptom presentation lead to early diagnosis; incidental or symptomatic results were the basis for late diagnosis. Overall  Survival(OS)  , progression_ free survival (PFS), quality  of life(QoL) , and frequency of serious adverse events associated to therapy were the outcomes.
Results: At a median 'OS of 38 months compared to 14 months in the late diagnosis group (p<0.001)  and median PFS of 34 months compared to 10 months(p<0.001), the early diagnosis group  showed noticeably  superior results. At 12 months, 'the early diagnosis group had a better QoL scores'  a mean global health status of 75 compared to 55(p<0.01). Early diagnosis group (18%) had a lower frequency of serious adverse effects than did the late  diagnosis group(45%).
Conclusion: In patients with lung cancer, early detection and intervention greatly increases survival rates, prolong intervals without progression, improves quality of life, and lower  serious side effects associated to therapy. The results emphasized the need of early diagnosis techniques and efficient screening programs in the treatment  of lung cancer.
Keywords: lung Cancer, early diagnosis, low dose computed tomography,  overall survival, progression free survival, quality of life, treatment related adverse events
Understanding Techniques, Risks, and Recovery for Enhanced Patient Care of Laparoscopic Appendectomy
Authors: Ahmad Jawad , Imtiaz Ali  , Akhtar Haseeb , Ud Din Awan Shahab , Khan Usman , Ijaz Furqan
Published: July 2024

Introduction: Because laparoscopic appendectomy is a less intrusive procedure with good results, it has become the accepted surgical treatment for acute appendicitis. In order to improve patient care, this study sought to thoroughly examine the methods, related hazards, and recuperation times of laparoscopic appendectomy.
Methodology: A retrospective cohort study comprising 87 patients who had laparoscopic appendectomy between June 2023 and May 2024 was carried out at District Headquarters (DHQ) Hospital Kohat. Patient demographics, surgery specifics, problems, and recovery results were all recorded. To assess the data, statistical analysis such as t-tests and chi-square tests were carried out.
Results: The study population's mean age was 34.5 years, and its male to female ratio was slightly greater (57.5%). The average operating duration was 65.2 minutes, and in 13.8% and 39.1% of cases, respectively, differences in surgical technique—such as the use of SILS and advanced energy devices—were noted. The incidence of complications was minimal, with 2.3% of patients experiencing intraoperative injuries, 8.0% experiencing postoperative infections, and 4.6% developing abscesses. There were no discernible variations between male and female patients' recovery results or complication rates.
Conclusion: This study demonstrates that laparoscopic appendectomy is safe, effective, and has a low risk of complications and good recovery results when treating acute appendicitis. The results validate laparoscopic procedures as the gold standard surgical method. To improve surgical methods and postoperative care guidelines and eventually improve patient outcomes, further research is necessary.
Boswellia serrata intoxication manifesting with syndrome of inappropriate antidiuretic hormone secretion, hyponatremia, seizure, and rhabdomyolysis
Authors: Finsterer Josef
Published: July 2024

ABSTRACT Boswellia serrata is an herbal extract from the Boswellia serrata tree that has anti-inflammatory and analgesic properties and alleviates pain caused by rheumatoid arthritis, gout, osteoarthritis, and sciatica. Syndrome of inappropriate antidiuretic hormone secretion accompanied by hyponatremia, seizures, and rhabdomyolysis as a manifestation of Boswellia serrata intoxication has not been reported previously. A 38-year-old female suffered clinically isolated syndrome and has since been regularly taking B. serrata capsules (200mg/d) to strengthen her immune system. She experienced hypersensitivity to light, ocular pain, nausea, dizziness, and lower limb weakness four days after receiving her first BNT162b2 vaccine dose, and she increased the dosage of B. serrata to five capsules (1000mg/d) one week after vaccination. After taking B. serrata at a dosage of 1000mg/d for 3 weeks, she was admitted to the intensive care unit because of a first, unprovoked generalized tonic–clonic seizure. The patient's workup revealed syndrome of inappropriate antidiuretic hormone secretion, which resolved completely upon treatment and discontinuation of B. serrata. In summary, B. serrata potentially causes syndrome of inappropriate antidiuretic hormone secretion when it is taken at high doses. Patients should not self-medicate.