bluuebunny/crossref_metadata_2025 huggingface dataset:
Права і свободи людини
Authors: Булавіна Світлана , Гороть Алла , Максимчук Оксана
Published: October 2024

У навчально-методичному виданні висвітлено становлення і розвиток прав людини, розкрито обсяг та складові прав людини (право на життя, свободу та особисту недоторканість, свободу думки, совісті та релігії та ін.), дано короткий зміст лекційних питань, проаналізовано практику Європейського Суду з захисту прав людини, щодо розгляду конкретних справ та акцентовано увагу на значенні прийнятих ним рішень. Навчально-методичні рекомендації розраховано для оптимізації самостійної, індивідуальної роботи здобувачів освіти денної та заочної форми навчання, спеціальності: 014 Середня освіта (Історія та громадянська освіта) факультету історії, політології та національної безпеки Волинського національного університету імені Лесі Українки, відповідно до вимог кредитно-модульної системи навчання, ТДН та Силабусу.
The Opportunity of Understanding Victims of Virtual Violence: Bingöl Example
Authors: BAYEZİT Galip , ÇETİNTAŞ Ahmet
Published: October 2024

Teknoloji ilerledikçe, şiddetin yeni bir boyut kazandığı görülmektedir. Bunun yanı sıra, dijital araçların yaygınlaşmasıyla birlikte, şiddetin olumsuz sonuçları da artmaktadır. Sanal şiddet vakaları; bilhassa sosyal medyada kişisel
verilerin hukuka aykırı bir şekilde yayınlanması, şantaj, tehdit, hakaret ve taciz şeklinde gerçekleşmektedir. Amacımız, sanal şiddet vakalarını etkileyen faktörleri tahlil ederek birey ve toplum hayatına yansımalarını ortaya koymaktır.
Nitel bir araştırma özelliği taşıyan bu çalışmada veriler, derinlemesine görüşme tekniğiyle toplanmıştır. Bingöl ilinin farklı ilçelerinde ikamet eden, 18 yaş üstü bireylerden örneklem grubu oluşturulmuştur. 2022 yılında gerçekleşen
bir sanal şiddet vakasının mağduru olan 20 kişi ile yüz yüze görüşme yapılarak toplanan veriler, betimsel analiz tekniğiyle tahlil edilmiştir. Araştırma bulguları, sanal şiddetin mağdurlarının sosyal statü açısından orta düzeyde
yoğunlaştığını ve kadınların erkeklere kıyasla daha fazla siber zorbalığa maruz kaldığını göstermektedir.
TREND ANALYSIS OF AVERAGE TEMPERATURE AND TOTAL PRECIPITATION DATA OF SUSURLUK STREAM BASIN
Authors: COŞKUN Mücahit , GÖZALAN Sıracettin , ÖZTEKİNCE Muhammet , DÜNDAR Özlem
Published: October 2024

Araştırma alanı Susurluk Çayı Havzası olup, araştırma konusu havzada bulunan 30 yılı aşkın gözlemlerle (1979-2019) 8 meteoroloji istasyonundaki ortalama sıcaklık ve toplam yağış parametrelerinin trend analizidir. Çalışmanın amacı,
uzun yıllardır havza genelinde ölçüm yapan meteoroloji istasyonlarının aylık ölçülen ortalama sıcaklık ve yağış verilerini dikkate alarak bu verilerin yıllık ve mevsimsel eğilimlerini analiz etmektir. Araştırmada trend yöntemleri
olan Mann-Kendall testi ve Spearman's Rho testi uygulanmıştır. Elde edilen sonuçlara göre havza genelinde hem yıllık hem de mevsimsel olarak ortalama sıcaklıklarda önemli artışlar gözlendi. Susurluk Çayı Havzasında yaz mevsimi,
sıcaklıkta gözlenen önemli ve kuvvetli pozitif eğilimin en güçlü olduğu mevsimdir. Havza genelinde yaz, sonbahar ve kış mevsimlerinde ve yıllık yağışlarda önemli bir artış veya azalma olmamıştır. Havzada gözlenen sıcaklık artışlarının
yıllık ve mevsimsel yağışlara önemli bir etkisinin olmadığı görülmüştür.
Keterkaitan Tingkat Efektifitas Metode Fitoremediasi Terhadap Tingkat Pertumbuhan Media Eceng Gondok Pada Limbah Cair C6+
Authors: Safitri Dewi , Patandjengi Baharuddin , Syahrul Muhammad , Fahruddin  , Budimawan  , Demmallino Emmal Basham
Published: October 2024

Liquid waste of Cr6+  is often produced by nickel ore mining companies, one of which is CV. Unaha Bakti Persada has a Cr6+ concentration of 0.78 ppm which has not yet reached the 0.1 ppm quality standard, so it is necessary to treat Cr6+ waste using an in vitro phytoremediation technique for water hyacinth media of E. azurea and E. crassipes. The purpose of this study was to determine the effectiveness of phytoremediation method, the level of damage to water hyacinth and the rate of growth of the water hyacinth plant. The study used an in vitro phytoremediation method for water hyacinth media E. crassipes and E. azurea for 15 days. The results showed that the effectiveness of water hyacinth E. azurea was 87% able to reduce the concentration of Cr6+ 0.78 ppm to 0.1 ppm within 15 days, while E. crassipes and the combination of E. crassipes and E. azurea were 64%. The rate of water hyacinth damage to Cr6+ wastewater was faster in E. azurea, namely 40% compared to E. crassipes by 27% and the combination of E. crassipes and E. azurea by 13%. The growth of water hyacinth in Cr6+ wastewater was faster in the combination of E. Crassipes and E. azurea, namely plant weight 45%, root length 38%, plant height 23% compared to E. azurea, namely plant weight 35%, root length 32%, height plant 17%, and E. crassipes, namely plant weight 45%, root length 38%, plant height 7%.
PEMANFAATAN ISOLAT BAKTERI DEKOMPOSER SEBAGAI BIOAKTIVATOR KOMPOS
Authors: Hazra Fahrizal , Rahmadani Ghina Radhiyya , Rosita Risa
Published: October 2024

Kompos merupakan pupuk organik yang berasal dari hasil pelapukan bahan-bahan organik. Proses pengomposan secara konvensional membutuhkan waktu yang lama sehingga diperlukan penambahan bioaktivator untuk mempercepat proses pengomposan. Environmental Technology and Security (ETS) section SEAMEO BIOTROP pada tahun 2023 menghasilkan BIOTROP Kompos (BIOPOS) sebagai hasil pengelolaan mandiri sampah dedaunan dan baglog jamur di SEAMEO BIOTROP. Namun, BIOPOS masih perlu dikembangkan lebih lanjut untuk dilakukan eksplorasi bakteri dekomposer yang dapat dijadikan bioaktivator BIOPOS guna mempercepat proses pengomposan dan meningkatkan kualitas kompos yang dihasilkan. Penelitian ini bertujuan mengisolasi, karakterisasi, dan menguji efektivitas bakteri dekomposer sebagai bioaktivator BIOPOS dalam mendekomposisi bahan organik. Isolat bakteri BIOPB, BIOKB, BIOPI, KSCMI, dan TJCMB dikarakterisasi secara morfologi, fisiologi, dan biokimia. Metode eksperimental dilakukan dalam pembuatan dan pengaplikasian bioaktivator BIOPOS. Hasil karakterisasi menunjukkan isolat bakteri BIOPB, BIOKB, KSCMI, dan TJCMB berpotensi sebagai bakteri dekomposer. Isolat bakteri dekomposer lebih efektif dalam mendekomposisi bahan BIOPOS dibandingkan EM4 dilihat dari tingginya suhu BIOPOS yang mencapai 52°C.
PEMBERDAYAAN MASYARAKAT MELALUI PENGOLAHAN TOMAT MENJADI DODOL DI DESA LENDANG NANGKA KECAMATAN MASBAGIK KABUPATEN LOMBOK TIMUR
Authors: Safira Adinda , Lampiron Muhamad , Hasbullah Rakhan Qurani , Annisa Karini Nudia , Azkia Tauchid Mauli , Hilyatunnisa Elok Sarah , Fakhrurrizal Muhammad , Afra Alzena Bunga , Elvira Damayanti Queeny , Nurhasanah Jamalullail Syarifah , Alamsyah Ahmad
Published: October 2024

The high rate of Indonesian people's appetite for snacks demands the production of snacks that comply with SNI, have good quality and are healthy. Tomatoes are one of the fruits that contain various nutrients and antioxidants that are needed by the body. Tomatoes can be processed into a variety of healthy and quality snack products including tomato dodol. The purpose of this community service activity is to improve community skills in processing dodol as a healthy snack made from tomatoes, while overcoming the problem of excessive tomato production in Lendang Nangka Village. The method used in this service is an action research approach combined with socialization of training in processing and packaging tomato dodol to the community in Lendang Nangka Village, Masbagik District, East Lombok Regency. The socialization and training of tomato dodol processing received enthusiasm and good attention from the women members of KWT and members of youth organizations.
INOVASI ABON IKAN TONGKOL BERBASIS EKONOMI IRU DI DUSUN PANDANAN DESA MALAKA KECAMATAN PEMENANG KABUPATEN LOMBOK UTARA
Authors: Tira Hendry , Mandragiri I Gde Ananta Wijaya , Hidayat Lalu Ramdoni , Mettasari Febriani , Putriani Era , Wati Ema Rahma , Mardiyani Vini , Hidayah Alvin , Syafitri Dea Dahlania , Jayatri Ika , Irfani Nurul Kasytiana
Published: October 2024

Desa Malaka, Kecamatan Pemenang, Kabupaten Lombok Utara, memiliki potensi sumber daya laut yang melimpah, khususnya ikan tongkol yang dapat dimanfaatkan untuk meningkatkan perekonomian masyarakat setempat. Kegiatan pengabdian kepada masyarakat yang dilakukan oleh mahasiswa KKN Universitas Mataram bertujuan untuk membuat pelatihan inovasi rasa baru pada produk abon ikan tongkol dan sekaligus promosi produk. Metode yang digunakan ialah observasi dan wawancara pada awal survei dengan menghasilkan metode pelatihan yang rinci. Melalui pelatihan ini telah menghasilkan inovasi abon ikan rasa baru, berupa Spicy Lime Leaves. Selain itu, promosi produk dilakukan melalui media sosial seperti Instagram, Shopee, dan TikTok Shop untuk memperluas jangkauan pasar dan meningkatkan penjualan.
PEMANFAATAN DAUN MIYANA (Coleus Atropurpureus) DALAM PEMBUATAN REMPEYEK
Authors: . Sultan , Widianty Desi , Sari Nukta Indah Permata , Ulia Ratu , Akbar Rifki , Dwi Ari Utami Avista , Annah Sifa’ul J
Published: October 2024

Miana (Coleus Atropurpures) merupakan tanaman semak tinggi yang tumbuh pada lingkungan agak lembab atau sedikit berair. Selama ini masyarakat hanya memanfaatkan tanaman miana sebagai tanaman hias yang hidup di ladang atau kebun – kebun. Padahal berdasarkan penelitian telah ditemukan bahwa ekstrak daun miana memiliki berbagai macam khasiat diantaranya meredakan rasa nyeri, sebagai antiinflamasi, antioksidan, antimikroba, antibakteri, dan dapat mempercepat penyembuhan luka. Dengan teknologi pengolahan pangan yang sederhana, tanaman miana ini dapat diolah menjadi rempeyek yang dapat menjadi makanan cemilan untuk keluarga dengan nilai gizi cukup tinggi serta mendatangkan pendapatan tersendiri bagi keluarga.
Inovasi Teknologi Pengelolaan Sampah: Mendorong Budaya Kebersihan Pantai di Desa Labuhan Kertasari Menuju SDGs 12
Authors: Rohmayani Laeli , Zahra Dinda , Hardyansah Fitrah , Sideman Ida , Wijayanto Heri
Published: October 2024

Desa Labuhan Kertasari dikenal sebagai salah satu destinasi wisata bahari di Sumbawa Barat, tetapi menghadapi permasalahan serius terkait sampah, terutama plastik. Oleh karena itu, kegiatan ini bertujuan untuk meningkatkan kesadaran masyarakat akan pentingnya kebersihan pantai dan menerapkan teknologi tepat guna dalam pengelolaan sampah. Melalui sosialisasi dan pelatihan, masyarakat diajak untuk mengolah sampah plastik, khususnya tutup botol, menjadi produk bermanfaat seperti tempat tisu dan kotak sampah. Hasil kegiatan menunjukkan bahwa kegiatan ini berhasil meningkatkan kesadaran masyarakat dan mengurangi jumlah sampah plastik di pantai. Selain itu, kegiatan ini juga memberikan nilai tambah ekonomi bagi masyarakat setempat.
DERMATOSE OCUPACIONAL
Authors: Coelho Eliene Miranda , Santos Vanessa Trindade dos , Anjos Daniele Lima dos , Kietzer Kátia Simone , Martins Thayssa Nogueira , Moreira Ana Carolina Louzada , Santos Arthur Valente dos , Silva Milene Ferreira da Costa , Miranda Suziane Lopes , Batista Elana Miranda Afonso , Luz Anna Julia Costa da , Costa Nathalia Dantas Carvalho , Coelho Elielson Miranda , Almeida Raiane Sanches , Veiga Karen Alves
Published: October 2024

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Inhibition the Growth of Some Malignant Cells Lines by Alfalfa Aqueous Extract
Authors: A. Rafid abdul wahid.
Published: October 2024

The aim of the present study was to assess the cytotoxic activity of aqueous extracts of Alfalfa (Medicago sativa ) by using (MTT) (colorimetric assay) to measure the cytotoxic activity on two malignant tumor cell lines (AMN3 ) Ahmed Mohamed Nahi 2003 and (GB) Glioblastoma cell line ,and one type of normal cell line (MEF) Mouse Embryo Fibroblast cell line, through different exposure time (24, 48 ,and 72hrs ) and different concentration of aqueous extract ; (1000,500,250,125 ,and 62.5, mg/ml), the study was carried out in the Iraqi Center for Cancer and Medical Genetics Research ,The result showed that the aqueous extracts from alfalfa have significant effects P value ≤ 0.05 on the growth of AMN3 cell lines and GB malignant cell line in culture in dose and time- dependant manner ,Viability of cell lines decreased with time and concentration reaching its lowest value after 72 hrs of treatment with the highest concentration used (1000 mg/ml ). The results also indicated that GB cell lines were more sensitive to the Alfalfa aqueous extracts as compared with the growth of AMN3 cell lines . From the other side the result showed that there is no significant effect P value ≥ 0.05 of these aqueous extracts on the viability of normal cell line (MEF3 cell line). Only the treatment with higher concentration (1000µg/ml) after 72 hrs caused significant reduction P value ≤ 0.05 in the (MEF) cell line growth
Needs for a sustainable education and training of radiation science and radiation protection in Kano state of Nigeria
Authors: Habibu Ahmad Ibrahim  , Yusuf Abubakar Maitama Hotoro  , Yahaya Ado Sumaila  , Abubakar Sani Garba
Published: October 2024

Most of African countries have only few number of trained personnel’s that have the knowledge of Radiation Science and Radiation Safety. Nigeria is of this countries that have only few Radiation Scientists and Kano state in particular. Based on the IAEA basic safety standards and the 96/29 Euratom directives that stress on the need of educating societies on the hazardous nature of Radiation. The Humanity Care and Cancer Foundation in collaboration with some national institutions based in Kano state has also been giving awareness and educational training to children together with the general public on issues related to radiation science and its safety. We have observed that the public demand is very high on the need for educating the societies in Kano state of Nigeria on Radiation science and protection. In this research paper, we have identified the educational needs on Radiation science and protection in Kano state of Nigeria. However, we have also enumerated the available educational and training infrastructures, the human resources, as well as the importance of stake holders and their roles if a sustainable education and training program were to be developed in Nigeria and Kano State in particular.
Cleaner operations “revolutionizing liquid mud plants with sustainable practices”
Authors: Muhammad Ahsan  , Derek Beaton
Published: October 2024

The global imperative for an energy transition towards cleaner and more sustainable practices is more pressing than ever. As the world seeks to reduce its reliance on fossil fuels and curb carbon emissions, industries must explore innovative solutions. One such solution is the adoption of electric forklifts, especially in sectors like oil and gas, which traditionally rely on diesel-powered machinery. This paper examines the environmental benefits of replacing diesel forklifts with electric ones, focusing on significant carbon reduction. We will discuss the various types of electric forklifts, their operational advantages, and their impact on reducing greenhouse gas emissions. Additionally, this study provides a detailed regional market analysis, including market size, growth trends, and the factors driving the adoption of electric forklifts. By highlighting the role of electric forklifts in the broader context of the global energy transition, this paper underscores their potential as a crucial component in achieving a sustainable and low-carbon future.
Transforming Saudi Arabia’s chemical industry: A sustainable approach to drilling fluids
Authors: Muhammad Ahsan  , Maryam Aldubaisi
Published: October 2024

The Kingdom of Saudi Arabia is undergoing a significant transformation in its chemical industry as part of its broader commitment to achieving net-zero carbon emissions. This paper explores the integration of sustainability practices within the oil and gas drilling fluid chemical business, highlighting key methodologies and projects that contribute to this goal. By implementing comprehensive life cycle analysis (LCA) methodologies, Saudi Arabia aims to reduce the environmental impact of drilling operations while enhancing economic and operational efficiencies. This study presents an overview of the kingdom's strategic initiatives, projects, and the role of advanced technologies in driving sustainability within the chemical industry.
Influence of concentration and formulation of macrosalts in the nutrient medium on the indicators of meristem regeneration at the stage of introduction to culture in vitro in some aboriginal Don grapes varieties
Authors:   All-Russian Research Institute named after Ya.I. Potapenko of Viticulture and Winemaking – Branch of Federal State Budget scientific Institution «Federal Rostov Agricultural Research Center», Novocherkassk, Russian Federation, Rebrov A.N. , Ventsenostseva N.S. ,   All-Russian Research Institute named after Ya.I. Potapenko of Viticulture and Winemaking – Branch of Federal State Budget scientific Institution «Federal Rostov Agricultural Research Center», Novocherkassk, Russian Federation
Published: October 2024

Abstract. Rare indigenous grape varieties are of significant value for viticulture, breeding and preservation of genetic material. Often, ancient grape varieties, due to prolonged vegetative propagation, are infected with one or more chronic diseases (viruses, phytoplasmas, bacterial cancer). The most reliable way to improve the health of such plants is the method of apical meristems in in vitro culture. In which, on artificial nutrient medium, it is necessary to regenerate the plant from isolated extremely small apical explants (about 50-100 microns). One of the most important components of nutrient medium are macroelements. Not only their quantity is of great importance, but also the compounds they represent, as well as the balance and ratio of all elements in the nutrient medium. In this regard, the purpose of our study was to study the characteristics of mineral nutrition of grape plants of native Don varieties in in vitro culture. To do this, we studied the effectiveness of the most commonly used nutrient media in microclonal propagation. The experiments were carried out on four rare native Don varieties Plechistik oboepolyi, Bessergenevskiy №10, Musketnyi and Durman. Protocols used: Murashige and Skuug (MS), McCown Wood Plant (WPM), Chee and Pool (C2D), Quoirin & lepoivre (QL) and Anton Rebrov (AR1). The nutrient media differed only in the composition of macrosalts; all other components were added in equal quantities. The varietal response of the studied varieties was different. The Plechistik oboepolyi and Bessergenevskiy №10varieties regenerated best, and the Musketnyi and Durman varieties regenerated more poorly. It has been established that the composition of macroelements significantly affects the regeneration and differentiation of shoots in apical meristems. For most varieties, the most stable results were observed when using WPM and AR1 nutrient media. The worst development of explants in all varieties in the study occurred on MS and C2D media. Key words: apical meristem, introduction into in vitro culture, regeneration of explants, recipes for nutrient media, concentration of macronutrients, native Don varieties
Edizione diplomatico-interpretativa con facsimile digitale dell’Edictum Rothari, Ivrea, Biblioteca Capitolare, XXXIV (5)
Authors: Buzzoni Marina , Rosselli Del Turco Roberto
Published: October 2024

Il progetto editoriale delle Leges Langobardorum nasce da una collaborazione tra l’Università di Ca’ Foscari Venezia e l’Università degli Studi di Torino, le due unità di ricerca nell’ambito di un Programma di Rilevante Interesse Nazionale (PRIN PNRR 2022) in cui operano congiuntamente gli autori dell’edizione.
Il progetto si suddivide in due fasi. La prima fase è volta a fornire una edizione diplomatico-interpretativa dei testimoni principali delle Leges, partendo dall’Editto di Rotari trasmesso dai due testimoni ‘piemontesi’, ovvero: Vercelli, Biblioteca e Archivio Capitolare, CLXXXVIII e Ivrea, Biblioteca Capitolare, XXXIV (5). La seconda fase, più a lungo termine, prevede l’allestimento dell’edizione critica integrata del testo dell’Editto e di tutte le Leges, sulla base della collazione e recensione completa dei testimoni pervenuti. L’edizione sarà corredata di un glossario digitale dei termini longobardi.
I motivi per cui si è scelto di allestire un’edizione digitale basata su standard di codifica internazionali (gli schemi XML/TEI) sono molteplici. In primo luogo, la codifica TEI permette di gestire più livelli di edizione e di presentarli con a fronte le immagini del facsimile digitale dei testimoni selezionati: in questo modo si valorizza la dimensione storica di ogni documento, offerto ai lettori nel suo contesto paleografico e codicologico, oltre che linguistico e filologico. In secondo luogo, la flessibilità di un’edizione digitale consente di integrare le edizioni diplomatiche con l’edizione critica che sarà preparata una volta portata a termine la prima fase. Infine, ma non da ultimo, la pubblicazione sul web in modalità open access consente di raggiungere un pubblico più vasto, non esclusivamente accademico, in accordo con l’obiettivo di valorizzare e diffondere la conoscenza del Patrimonio Culturale italiano che è parte del progetto PRIN.
A digital predistortion system based on a generalized memory polynomial for GaN power amplifiers
Authors:   Omsk Scientific Center SB RAS (Institute of Radiophysics and Physical Electronics), 644024, Russia, Omsk, K. Marx Avenue, 15, Kashchenko I.E. , Pavlov A.P. ,   Omsk Scientific Center SB RAS (Institute of Radiophysics and Physical Electronics), 644024, Russia, Omsk, K. Marx Avenue, 15
Published: October 2024

Modern power amplifiers based on GaN transistors face a number of problems related to their physical properties and operating conditions. The high output power of such power amplifiers is accompanied by significant nonlinear distortions, especially when operating in saturation mode. Amplifiers based on GaN transistors have pronounced «short» memory effects, which leads to the dependence of current distortions on previous signal states. At the same time, support for broadband signals requires high processing speeds and large computing resources. Classical digital pre-distortion methods do not always cope with the task of effectively compensating for real-time distortion for power amplifiers based on GaN transistors. These problems complicate the process of linearization of power amplifiers based on GaN transistors and require the development of new methods that can effectively compensate for non-linearities and memory effects without significantly increasing the cost and complexity of the system. The purpose of the work is to create and analyze the effectiveness of a digital pre-imaging system based on a generalized polynomial model with memory to improve the linearity and efficiency of power amplifiers based on GaN transistors in wireless communication systems. The paper presents the architecture of the digital preimage input system based on a generalized polynomial model with memory. The use of this model makes it possible to improve the efficiency of suppressing nonlinear distortions at the output of a power amplifier based on GaN transistors. Practical significance – the proposed architecture can be implemented on FPGAs, VLSI or SOC with a minimum amount of computing resources.
The wet soil's dielectric model for south part of Western Siberia in the frequency range of 3 MHz – 1 GHz
Authors:   Omsk Scientific Center SB RAS (Institute of Radiophysics and Physical Electronics), 644024, Russia, Omsk, pr. K. Marksa, 15, Yashchenko A.S. , Varnakov S.A. ,   Omsk Scientific Center SB RAS (Institute of Radiophysics and Physical Electronics), 644024, Russia, Omsk, pr. K. Marksa, 15, Krivaltsevich S.V. ,   Omsk Scientific Center SB RAS (Institute of Radiophysics and Physical Electronics), 644024, Russia, Omsk, pr. K. Marksa, 15
Published: October 2024

The wet soil's dielectric model whose input parameters are frequency, volumetric moisture content, and physical clay content are presented. This model was developed based on statistical analysis of dielectric permettivity data for five soil samples with differ partical size distribution from steppe and forest-steppe climate zones within the territory of southern Western Siberia. A comparison of dielectric data obtained empirically and calculated using the model for one type of soil is carried out. The obtained results will find application in assessing the radiophysical characteristics of the underlying surface in the frequency range from 3 MHz to 1 GHz.
Vocabulary Notebooks as a Noteworthy Powerful Instrument in Technical Vocabulary Learning
Authors: Plaku Megi , Karapici Viola
Published: October 2024

This research paper attempts to investigate the organization and effectiveness of vocabulary notebooks by distinguishing several benefits the implementation of this technique brings in the acquisition of technical terminology through an “English for Specific Purposes course”. When tackling with language learning, it is needless to emphasize the noteworthiness and the importance of vocabulary in this process. Appertaining to technical terminology, this plays entirely pertinent. Various studies have concluded that vocabulary notebooks (henceforth VN) efficiently expose different learners’ strategies within this single strategy, which led us to research VN. These research data were obtained mainly by applying the observational research technique, a vocabulary oral and written exam, and a comprehensive questionnaire on the effectiveness of the Vocabulary Notebook. Mechanical Engineering, Textile Engineering, and Hydrotechnical Engineering students at the Polytechnic University of Tirana were selected to obtain the data. The observation is partly overt and partly covert. Students of Mechanical Engineering and Textile Engineering (75 students) are the treatment group wherein the Mechanical Engineering students are an overt group and the Textile Engineering students serve as the covert observational group while on the other hand, the Hydrotechnical Engineering (45 students) students are the control group. The data were obtained during and at the end of the semester. Throughout the observation all along the 1st semester, it was perceived that most of the students organized their VN by utilizing mainly Microsoft Word downloaded on their Smart Phones, while the rest used the traditional paper notebook to organize their technical VN. The organization of the VN reflected the strategies each of the students implemented to learn technical terminology. At the end, students were tested on their acquired terminology through an oral and a short-written exam and then a questionnaire was handed to them. The students of the overt group making use of a digitalized form of a Notebook resulted to have acquired most of the technical vocabulary. In the main, the overt group outperformed the covert group on the acquisition of technical vocabulary, while the control group’s score on the oral exam was significantly below, compared to the all-inclusive treatment group. Students’ questionnaire revealed that overall students had a positive approach to this strategy and they embraced the autonomy acquired throughout the semester by implementing this strategy. With the exception of the effectiveness on vocabulary acquisition, which was on higher levels, this strategy proved itself once again to be an enhancer and promoter of learner autonomy. Keywords: vocabulary notebooks, autonomous learning, technical terminology List of Abbreviations: VN – Vocabulary Notebook, ME – Mechanical Engineering, TE – Textile Engineering
Stakeholder Participation in The Revitalization of Peneleh Tourist Area in Surabaya City
Authors: Syahrul Hidayat  , Muhamad Muhamad , Soeprihanto John
Published: October 2024

This study aims to identify the form of stakeholder participation and collaboration in the revitalization of Peneleh tourism area to become an area of historical value and maintain the authenticity of the area. A qualitative method with stakeholder analysis was used to examine the participation and collaboration of stakeholders, including the government, local communities, academics, mass media and financial institutions.
The analysis found that the active involvement of stakeholders through the Pentahelix model is crucial for successful revitalization. The results show that stakeholder participation in Peneleh revitalization includes the participation of ideas, skills, energy, property, and money. In addition, collaboration between stakeholders in idea development, decision making, human resource development, revitalization implementation and preservation of revitalization results play an important role in the revitalization of Peneleh. Begandring Soerabaia community, as one of the key players in this project, successfully collaborated with various parties including the city government, academics, pokdarwis, mass media, Bank Indonesia and international institutions such as Time Amsterdam.
The conclusion of this study is that strong collaboration between various stakeholders, supported by active participation from the local community and support from other institutions, is the key to success in revitalizing a historical area such as Peneleh. This research also underlines the importance of a holistic approach, which includes physical, historical and cultural aspects in preserving historical heritage.
Keywords: Stakeholder Participation, Form of Participation, Pentahelix, Stakeholder Analysis, Revitalization
Effects of Hydroxychloroquine on Maternal and Fetal Outcomes in Pregnant Patients with Lupus: A Systematic Review and Meta-Analysis
Authors: Liu An-Hao , Li Xiu-Wen , Yu Yue-Wen , Xu Bin , Lei Rui , Ren Chong , Ruan Xue-Ru , Tian Li-Li , Ma Yu-Ping , Ye Ming-Zhu , Huang Xiu-Min , Chen Xun
Published: October 2024

Background: The effects of hydroxychloroquine (HCQ) on maternal and fetal outcomes in pregnant patients with systemic lupus erythematosus (SLE) have not been fully elucidated in recent research. This study aimed to provide a more comprehensive evaluation of the efficacy and safety of HCQ in pregnant patients with SLE. Methods: A systematic search of relevant articles was conducted using Medline, Embase, Scopus, Web of Science, and the Cochrane Library from inception to October 4th, 2023. The risk of bias in the included studies was assessed using the Newcastle-Ottawa Scale or Cochrane's Quality Assessment Form. Data on maternal and fetal outcomes of the HCQ treatment groups (HCQ+) and control groups (HCQ–) were extracted, analyzed and evaluated. Pooled odds ratios (ORs), pooled relative risks (RRs), and weighted mean differences with 95% confidence intervals (95% CIs) were calculated for the meta-analysis using Stata/MP V.18. Results: This meta-analysis included 17 studies, involving a total of 2238 pregnant patients with SLE. Compared to the HCQ– groups, the HCQ+ groups exhibited a significant reduction in the incidence of preeclampsia (RR = 0.51, 95% CI: 0.37–0.71), high lupus activity (RR = 0.77, 95% CI: 0.64–0.92), gestational hypertension (OR = 0.41, 95% CI: 0.18–0.91), premature delivery (RR = 0.71, 95% CI: 0.60–0.84), and fetal growth restriction (OR = 0.61, 95% CI: 0.43–0.85). Additionally, the HCQ+ groups exhibited a significant increase in fetal birth weight of 0.21 kg (95% CI: 0.09–0.33). No significant differences were revealed in the other 15 pregnancy outcomes between the two groups. Conclusions: Despite the presence of a certain heterogeneity among the included studies, this study provides a more comprehensive evaluation of the efficacy and safety of HCQ in pregnant patients with SLE.
Multisystem Health Consequences of Prenatal Hyperandrogenism in Offspring
Authors: Liu Dong , Chen Wenxi , Zhong Qian
Published: October 2024

Objective: Prenatal hyperandrogenism, characterized by elevated androgen levels during pregnancy, has significant multisystem impacts on offspring health. This review systematically examines the effects of prenatal hyperandrogenism on the cardiovascular, metabolic, reproductive, and behavioral health of offspring. By analyzing existing research, this review aims to provide a comprehensive understanding of the long-term health impacts of prenatal hyperandrogenism, offering insights for clinical management and prevention of related diseases. Mechanism: A comprehensive search was performed in PubMed database with the key words: “hyperandrogenemia and child”, “hyperandrogenemia and offspring”, “androgen excess and child”, “androgen excess and offspring”, “prenatal hyperandrogenism”, “prenatal androgen excess”, and a combination of these terms to find quality articles published from 1995 to 2024. Findings in Brief: Elevated prenatal androgen levels disrupt normal fetal development, leading to long-term consequences such as cardiovascular dysfunction, including hypertension and cardiac hypertrophy, and metabolic abnormalities such as insulin resistance and metabolic syndrome. It has a significant impact on the long-term health of the offspring’s reproductive system, with potential links to conditions such as polycystic ovary syndrome (PCOS). Furthermore, prenatal hyperandrogenism is associated with increased risks of neuropsychiatric disorders, including autism spectrum disorder (ASD) and anxiety. Conclusions: Elevated prenatal androgen levels disrupt normal fetal development, leading to long-term cardiovascular, metabolic, reproductive, and neuropsychiatric disorders. The underlying mechanisms involve hormonal regulation, placental function, oxidative stress, gene expression alterations, and metabolic programming. Further research is needed to develop effective interventions to mitigate these adverse effects.
Factors Influencing Postoperative Recurrence and Live Birth Achievement after Laparoscopic Surgery for Ovarian Endometrioma: A Retrospective Study in a Regional Core Hospital
Authors: Arakaki Ryosuke , Isono Wataru , Fukuda Hiroaki , Tanaka Junya , Minamino Arisa , Hayashi Shiko
Published: October 2024

Background: Ovarian endometrioma (OMA) is a common gynecological condition affecting women of reproductive age, often requiring laparoscopic surgery for removal. However, the management of OMA, including postoperative hormone therapy, is complex and must be tailored to the individual's conditions. Therefore, to provide meaningful insights, we aimed to analyze 10 years of accumulated data from patients who underwent laparoscopic surgery for OMA, with a primary focus mainly on postoperative OMA recurrence and live birth outcomes. Methods: We reviewed the medical records of 158 patients who underwent laparoscopic surgery for OMA, including total laparoscopic cystectomy (TLC) (79 patients), total laparoscopic adnexectomy (TLA) (62 patients), or both unilateral TLA and contralateral TLC (17 patients), between January 2014 and December 2023. Among the OMA patients, we identified 7 cases of postoperative OMA recurrence out of 158 patients, and 23 live births among 79 TLC patients. We performed a multivariate logistic regression analysis to assess the impact of each representative factor on postoperative OMA recurrence and live birth achievement. Results: The multivariate analyses of the 158 patients revealed that advance age and massive blood loss were significantly associated with an increased risk of postoperative OMA recurrence, while postoperative hormone treatment was associated with a decreased risk of recurrence. In the analysis of live birth achievement among the 79 TLC patients, advanced age, postoperative hormone treatment and cancer antigen 125 (CA125) positivity were significantly associated with a reduced likelihood of achieving live birth. Conclusions: Our data highlight the unfavorable effects of advanced age, massive blood loss and CA125 positivity on the outcomes of laparoscopic surgery for OMA. Additionally, postoperative hormone treatment was found to decrease postoperative OMA recurrence. These findings may offer more accurate information to guidance in selecting treatment options for patients with OMA.
The Impact of Microparticulate Air Pollution in Polycystic Ovary Syndrome: A Narrative Review
Authors: Stegehuis Narelle , Kotsirilos Vicki , Parker Jim
Published: October 2024

Objective: The aim of this narrative review is to summarize studies examining the relationship between microparticulate air pollution (MAP) and polycystic ovary syndrome (PCOS). Mechanism: PCOS is increasingly regarded as an evolutionary mismatch disorder that manifests in women due to exposure to a range of lifestyle and environmental factors. Although the underlying causes of PCOS remain debated, environmental factors such as endocrine-disrupting chemicals (EDC), may contribute to its pathogenesis due to their well-documented hormonal and metabolic effects. MAP is another significant environmental exposure that has been associated with a variety of chronic diseases, as well as adverse hormonal and metabolic effects, including PCOS. Chronic low-grade inflammation and insulin resistance (IR) are key pathophysiological features of PCOS that have been associated with inhalation and ingestion of MAP. Findings in Brief: Our search identified four studies that systematically examined the relationship between MAP and PCOS. One population-based cohort study showed an increased risk of PCOS with increased exposure to various air pollutants, including MAP. A second population-based study showed a decreased risk of PCOS with increasing levels of exposure, while a longer duration of exposure was associated with an increased risk of PCOS. A third study found that conception rates were lower in women with PCOS exposed to second-hand smoke (SHS) compared to non-exposed women. In contrast, a fourth study reported that exposure to air pollutants was not associated with reduced pregnancy outcomes. These data suggest that both the concentration and duration of exposure to MAP may be important factors, and that reproductive outcomes could be affected by exposure to MAP through second-hand cigarette smoke. Conclusions: Preliminary data suggest that MAP may contribute to an increased risk of PCOS, although the available evidence remains inconsistent. Nevertheless, the current evidence supports advising women to avoid exposure to SHS and MAP whenever possible. This review highlights the need for further research on the effects of MAP in women with PCOS.
Correlation between Immune Factor Expression and Prognosis of Plasma Cell Mastitis Surgery and its Predictive Value for Prognosis
Authors: Li Shangwei , Lin Xiao
Published: October 2024

Background: To study the correlation between the expression of immune factors and the prognosis of surgical treatment of plasma cell mastitis (PCM) and to analyze its predictive value for the prognosis of patients. Methods: 89 female patients with PCM treated in our hospital from June 2020 to September 2022 were divided into good prognosis group (69 cases) and poor prognosis group (20 cases). Logistic regression was used to analyze the influencing factors of poor prognosis of surgical treatment for PCM, and to explore the correlation between these immune factors and the prognosis of surgical treatment for PCM. Draw the receiver operating characteristic (ROC) curve to analyze the predictive value of the above indexes for the prognosis of patients with PCM. Results: After 4 weeks of treatment, the levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were significantly lower than before treatment (p < 0.05), and the level of interleukin 10 (IL-10) was significantly higher than before treatment (p < 0.05). At the time of admission, there was no significant difference in the clinical data and the levels of TNF-α, IL-6 and IL-10 between the two groups (p > 0.05). After 4 weeks of treatment, the indexes of TNF-α and IL-6 in the poor prognosis group were higher than those in the good prognosis group (p < 0.05). Logistic regression analysis showed that the levels of TNF-α (odds ratio (OR) = 1.551, 95% confidence interval (95% CI): 1.276–1.886) and IL-6 (OR = 1.082, 95% CI: 1.046–1.119) were increased, which were risk factors for the prognosis of PCM (OR >1). Correlation analysis showed that TNF-α and IL-6 were negatively correlated with the prognosis of PCM, while IL-10 was positively correlated with the prognosis of PCM. ROC curve analysis showed that the areas under the curve for TNF-α, IL-6 and IL-10 to predict the prognosis of surgical treatment of PCM were 0.896, 0.931 and 0.709 respectively. Conclusions: The expression of immune factors such as TNF-α, IL-6 and IL-10 is closely related to the prognosis of surgical treatment of PCM, which has high predictive value for its prognosis.
Immune Thrombocytopenia: Immune Dysregulation and Genetic Perturbations Deciphering the Fate of Platelets
Authors: Tariq Zahra , Qadeer Muhammad Imran , Zahid Khadija , Cherepkova Elena Vladimirovna , Olzhayev Sayakhat Taurbekovich
Published: October 2024

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. It involves impaired production and excessive destruction of platelets. It is a complex and heterogeneous disorder with unknown pathophysiology. Both genetic and immunologic perturbations have been implicated in the disease pathogenesis. Immune dysregulations involve both the humoral and cellular immunity. Attack of anti-platelet autoantibodies has been found to be the fundamental cause of platelet destruction. Other mechanisms including T cell mediated platelet destruction, complement activation, apoptosis, and desialylation have also been found in the development of ITP. Genetic testing has revealed various predispositions including single nucleotide polymorphisms (SNPs), copy number variations (CNVs), and epigenetic changes in the immunoregulatory genes of ITP subjects. Varying methylation patterns have also been found in the immune-related genes. This review summarizes the dysregulated immune cells, immunologic cascades, altered signaling pathways, genetic mutations and epigenetic changes in ITP pathogenesis. These alterations induce autoimmune responses against the platelets resulting in complex bleeding manifestations and onset of ITP.
A Dot-Blot Screening for Identifying the Temozolomide-Regulated Proteins as Potential Targets for Glioma Multi-OMICS Studies
Authors: Bielecka-Wajdman Anna Maria , Machnik Grzegorz , Linnebacher Christina , Linnebacher Michael , Stec-Grosman Katarzyna , Obuchowicz Ewa
Published: October 2024

Background: Malignant gliomas represent a heterogenous group of brain cancers that are characterized by infiltrative growth that lacks a clearly identifiable tumor border. The lack of the possibility of radical surgical resection and targeted therapy results in a poor prognosis. Although Temozolomide (TMZ) is still the leading chemotherapeutic agent in glioma treatment, its efficacy is limited due to the development of tumor resistance. Therefore, there an urgent need to improve the diagnosis and treatment of these tumors. Finding and developing biomarkers that are specific to glioma could be useful for both identifying therapy targets and monitoring treatment as well as for constructing a personalized therapy. However, there are still no reliable markers that would change the quality of glioma treatment. Methods: In this study, differences in the expression of 84 cancer-related proteins in three glioma cell lines were analyzed using the dot-blot method: commercial T98G cells and two patient-derived cell lines. The influence of TMZ on changes in protein expression, cell morphology, and migration was also investigated (Proteome Profiler Human XL Oncology Array, LeviCell System, Microscopic imaging). The lines that were analyzed were characterized by a remarkably different plasticity of protein expression and the proteomic alterations that were induced by TMZ. Results: A dot-blot analysis revealed ten proteins that were common to all of the lines and five (Cathepsin b, FGF, Survivin, AXL, Osteopontin) that were modulated by the TMZ. As a result of the exposure of TMZ, the proteins that are involved in chemoresistance and invasion (TIE-2, Thrombospondin) were detected in both the HROG02 and T98G cell lines. In the control culture (not exposed to TMZ) of HROG17 cells, the proteins that are involved in metabolism were strongly suppressed. Conclusions: The presented data sheds new light on the modulatory effect of Temozolomide on the expression of a protein panel: Cathepsin b, fibroblast growth factor (FGF), Survivin, AXL, and Osteopontin that may suggest their potential as therapeutic targets or biomarkers to monitoring therapy effects. However, further high-throughput analysis and detection of the proteins in the body fluids are necessary.
Mitochondrial DNA Alterations in Glioblastoma and Current Therapeutic Targets
Authors: Kurdi Maher , Bamaga Ahmed , Alkhotani Alaa , Alsharif Thamer , Abdel-Hamid Ghada A , Selim Mohamed E , Alsinani Taghreed , Albeshri Ahmed , Badahdah Adnan , Basheikh Mazen , Baeesa Saleh
Published: October 2024

Metabolic reprogramming within tumor cells involves a shift towards either glycolysis or mitochondrial respiration, depending on the stage of tumor progression. Consequently, irreversible dysfunction of the mitochondria is considered a crucial mechanism driving the progression mechanism. While numerous mutations in mitochondrial DNA (mtDNA) have been identified across various tumor types, including glioblastoma, many studies have been limited in the scope, focusing on small segments of mtDNA or utilizing sequencing methods with restricted sensitivity. As a result, several potentially significant mtDNA mutations may have been underestimated, along with their heteroplasmic states, which play a crucial role in determining the phenotypic impact of mtDNA mutation. Although both somatic and germline mtDNA mutations have been observed in different tumor types, research on the mtDNA mutations linked to glioblastoma remains scarce. The mitochondrial genome encodes thirteen protein-coding genes that are essential for the proper functioning of respiratory complex chains. Alterations in mitochondrial function manifest at various levels, including structural and functional changes, impacting mitogenic, hemodynamic, bioenergetic, and apoptotic signaling pathways. These alterations often signify a reduced efficiency of the oxidative phosphorylation system and energy production in tumor cells. As the crucial role of mitochondrial dysfunction in glioma development grows, mitochondria have emerged as promising targets for therapy aimed at overcoming chemoresistance and eliminating cancer cells. This brief review outlines the association between mtDNA alteration and glioblastoma, as well as the current advancements in therapeutic strategies targeting mtDNA alterations.