bluuebunny/crossref_metadata_2025 huggingface dataset:
SAÚDE DO HOMEM NA ATENÇÃO BÁSICA: FATORES QUE INFLUENCIAM A BUSCA PELO ATENDIMENTO
Authors: Disney Silva Júnior Clausson , Rodrigues de Souza Jéssica , Santana Silva Natatia , Pereira de Almeida Shirley , Machado Torres Lilian
Published: November 2022

Introdução: Alguns aspectos influenciam o distanciamento dos homens em buscar atendimento nas Unidades de Saúde. Objetivo: Analisar os fatores que influenciam o atendimento à saúde do homem na Atenção Primária de Saúde. Metodologia: Pesquisa qualitativa realizada em uma Unidade Básica de Saúde de Belo Horizonte. Foram entrevistados homens entre 18 e 59 anos atendidos no referido serviço. O conteúdo dos depoimentos foi submetido à análise temática de conteúdo. Resultados: Os participantes desconhecem a política a eles direcionada e expressaram como se sentem durante a atenção, diante da demora no atendimento e do desejo de serem assistidos como as mulheres. Emergiram três categorias: (Des)Conhecendo as políticas de saúde; A busca pelos serviços de saúde; e A insatisfação dos homens: revelando fatores que dificultam a procura aos serviços de saúde. Conclusões: Urge identificar a satisfação do público alvo. Capacitação e sensibilização permanentes das equipes concorrem para melhorias do cuidado cotidiano.

Palavras-Chave: Saúde do Homem; Enfermagem; Atenção Primária à Saúde; Satisfação do Paciente.
La esperanza apocalíptica, una clave para la evangelización en tiempos de pandemia
Authors:   Pontificia Universidad Católica de Ecuador, Guerra Carrasco José
Published: November 2022

¿Cómo hablar del Reino de Dios en nuestro presente eclesial, social y cultural, plagados de multi pandemias? En situaciones confusas como los que vivimos en este aún joven siglo XXI, se vuelve imperativo recuperar la esperanza apocalíptica para dar sentido a las vidas y luchas de nuestros pueblos, que obstinadamente siguen creyendo que el Señor de la vida está por encima de los dioses de la muerte. Este artículo busca recuperar el mensaje de Jesús para releer nuestra historia, la Palabra de Dios y la misión de la Iglesia, como exigencia que no podemos rehuir. Sólo desde el mensaje proclamado y testimoniado por Jesús podemos dar un mensaje nuevo en ardor, contenidos y expresiones, que sirva para alimentar la espera, hasta la plenitud del Reino de Dios.
The Radioprotective Potentials of Silymarin/Silibinin Against Radiotherapy-
Induced Toxicities: A Systematic Review of Clinical and Experimental
Studies
Authors: Latacela Gloria Alexandra , Ramaiah Pushpamala , Patra Indrajit , Jalil Abduladheem Turki , Gupta Reena , Madaminov Fakhriddin Akhmadovich , Shaker  Shafik Shafik , Al-Gazally Moaed Emran , Ansari Mohammad Javed , Kandeel Mahmoud , Mustafa Yasser Fakri , Farhood Bagher
Published: November 2022

Background:

Although radiotherapy is one of the main cancer treatment modalities, exposing
healthy organs/tissues to ionizing radiation during treatment can lead to different adverse effects.
In this regard, it has been shown that the use of radioprotective agents may alleviate the ionizing
radiation-induced toxicities.

Objective:

The present study aims to review the radioprotective potentials of silymarin/silibinin in
the prevention/reduction of ionizing radiation-induced adverse effects on healthy cells/tissues.

Methods:

Based on PRISMA guidelines, a comprehensive and systematic search was performed
for identifying relevant literature on the “potential protective role of silymarin/silibinin in the treatment
of radiotherapy-induced toxicities” in the different electronic databases of Web of Science,
PubMed, and Scopus up to April 2022. Four hundred and fifty-five articles were obtained and
screened in accordance with the inclusion and exclusion criteria of the current study. Finally, 19 papers
were included in this systematic review.

Results:

The findings revealed that the ionizing radiation-treated groups had reduced survival rates
and body weight in comparison with the control groups. It was also found that radiation can induce
mild to severe adverse effects on the skin, digestive, hematologic, lymphatic, respiratory, reproductive,
and urinary systems. Nevertheless, the administration of silymarin/silibinin could mitigate the
ionizing radiation-induced adverse effects in most cases. This herbal agent exerts its radioprotective
effects through anti-oxidant, anti-apoptosis, anti-inflammatory activities, and other mechanisms.

Conclusion:

The results of the current systematic review showed that co-treatment of silymarin/silibinin
with radiotherapy alleviates the radiotherapy-induced adverse effects in healthy cells/tissues.
Exploring the Phosphatidylcholine in Inflammatory Bowel Disease: Potential
Mechanisms and Therapeutic Interventions
Authors: Cui Bota , Ai Rujun , Xu Jie , Ji Guozhong
Published: November 2022

Background:

Inflammatory bowel disease (IBD) is a significant health problem with an increasing financial burden worldwide. Although various treatment strategies have been used, the results were not satisfactory. More and more researches have proved that the application of phosphatidylcholine (PC) may become an alternative therapy for IBD.

Objective:

This review aims to provide an overview of the possible mechanisms of PC and promote the potential application of PC for IBD therapy further.

Methods:

A comprehensive literature search was performed in PubMed with the following keywords: ‘phosphatidylcholine’, ‘inflammatory bowel disease’, ‘Crohn's disease’, ‘inflammation’, ‘ulcerative colitis’, ‘therapy’, ‘nanomedicines’, ‘PKCζ’, ‘lysophosphatidylcholine’, ‘microbiota’ and ‘drug carrier’. The logical operators
“AND” and “OR” were applied to combine different sets of the search results.

Results:

Studies suggested that PC displays a significant effect in the treatment of IBD by modulating gut barrier function, remodeling gut microbiota structure, regulating polarization of macrophages, and reducing the inflammatory response. PC has also been exploited as a drug carrier for anticancer or anti-inflammation agents in
multiple forms, which implies that PC has immense potential for IBD therapy.

Conclusion:

PC has shown promising potential as a new therapeutic agent or a drug carrier, with a novel, stable, prolonged mechanism of action in treating IBD. However, more high-quality basic and clinical studies are
needed to confirm this.
Applications of Transesterification in the Synthesis of Commercial and Noncommercial
β -Ketoesters/Esters, Medicinally Important Heterocycles and Production of
Biodiesel
Authors: Bendi Anjaneyulu , Rao G.B. Dharma
Published: November 2022

Transesterification is one of the paramount chemical reactions in organic synthesis
and is broadly used to synthesize the biologically and pharmacologically active heterocycles
of greater medicinal importance. The transesterification reaction provides the useful synthon
called β-ketoester, which bears both electrophilic and nucleophilic reactive centers, which is
helpful for the construction of various complex structures with greater medicinal properties.
This article discusses various methods to synthesize β-keto esters/esters via transesterification
through catalysis, including nanocatalysts, and different applications of transesterification
reactions in the preparation of biologically active heterocycles and production of biodiesel
have also been summarized as per the available literature. The main focus of the current study
is to highlight the importance of transesterification in synthesizing variety of commercial and noncommercial β -
ketoesters / esters, which will be used to synthesize various biologically important heterocycles and production of
biodiesel.
Potential of Surface Functionalized Nanomaterials in Innovative Drug
Development: A Mini-review
Authors: Ditta Sarwar Allah , Yaqub Atif , Tanvir Fouzia
Published: November 2022

The unique properties of nanomaterials (NMs) make them special entities for biomedical innovation and research. Early diagnosis and follow-up of diseases are easily possible with the help of nanotechnology and nanomedicine, which can help combat any medical condition. Surface functionalization
with specific molecules might impart marked properties to NMs, leading to the modification of cellspecific interactions within the biological systems. This modification may provide excellent phenomena
for innovative drug development. Modified NMs might play essential roles in various applications, i.e., in
vivo diagnostics, magnetic resonance imaging (MRI), positron emission tomography (PET), etc. Functionalization of NMs with appropriate ligands, small molecules, or polymers assigned them enhanced
stability, biocompatibility, and functionality for their novel and improved biological applications. Surface
functionalized NMs might display enhanced antimicrobial, antidiabetic, and drug delivery potential for
various applications. Different studies reported the potential of functionalized metallic nanoparticles in
regenerative medicines. Conjugation of NMs with various molecules such as peptides, small ligands,
polysaccharides, proteins, saturated and polyunsaturated fatty acids, siRNA, plasmids, and DNA, might
be achieved by various reactions. Biomolecule-conjugated nanoparticles result in the production of hybrid
NMs with specific and novel biological interactions in biological systems. Chemical treatment methods
are considered among the most trusted and efficient functionalization methods. Some commonly used
techniques and strategies of functionalization involve grafting to and grafting from methods, ligand exchange technique, covalent bonding, chemisorption, non-covalent interactions, electrostatic adsorption,
etc. This brief review is dedicated to the surface functionalization of NMs with the latest development
Foot Functional Disability in Rheumatoid Arthritis: The Involvement of
Body Mass Index
Authors: Boussaid Soumaya , Jeriri Sarra , Hannech Emna , Rekik Sonia , Jammali Samia , Cheour Elhem , Sahli Hela , Elleuch Mohamed
Published: November 2022

Introduction:

Overweight and obesity are common in patients with Rheumatoid Arthritis (RA), with a probable impact on bearing foot joints.

Aim:

Our study aimed to explore the impact of Body Mass Index (BMI) on foot health parameters in RA patients.

Methods:

It was a cross-sectional study. Domains of foot health explored were: foot pain (Numeric Rating Scale), foot-related activity limitations (Foot Function Index (FFI), and WOMAC scale), foot synovitis, foot deformity (Platto Score (PS)), radiological joint damage and footwear problems.

Results:

Fifty RA were included, 82% were female. The mean age was 45.68 ± 10.3 years. The mean DAS28-CRP was 3.25 ± 0.98. Sixty-six percent were overweight or obese, with a mean BMI of 29 Kg/m2 ± 5.74. The average foot pain intensity while walking was 6 ± 1.75. The mean swollen foot joint was 2.2 ± 1.55. The average foot structural index was 7.8 ± 2.73. The mean FFI Disability score was 32 ± 14.2 and WOMAC score was 33.8 ± 13.98. Half of our patients had footwear prob-lems predominantly because of claw toe (40%). High BMI was significantly correlated with foot pain and foot-related activity limitations. It was also correlated with foot deformities assessed with PS (B=4.78; CI(3.87-5.68); p = 0.02), foot synovitis (OR=4.66, CI(2.61-8.32); p < 0.001) and prob-lems with footwear (OR= 0.32; CI(0.18-0.56); p = 0.05). However, it was significantly associated with less radiological joint damage (CI(-0.7-1.1); p = 0.01) and lower foot sharp score (B = -13.9; CI(-0.34-0.01); P = 0.06).

Conclusion:

Despite our findings of a possible protective effect of obesity on structural damage, obesity is still an important cause of increased pain, functional disability, and impaired QoL in RA patients.
Expediting Molecular Translational Approach of Mesenchymal Stem Cells
in COVID-19 Treatment
Authors: Balaji Easwaran Vignesh , Satarker Sairaj , V Gujaran Tanvi , John Jeena , Veedu Anuranjana Putiya , George Krupa Thankam , Purayil Divya Kunhi , Beegum Fathima , Mathew Anna , Vibhavari RJA , Chaudhari Sneha Sunil , Pai K Sreedhara Ranganath
Published: November 2022

Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 with severe respiratory failure and organ damage that later appeared as a pandemic disease. Worldwide, people’s mental and physical health and socioeconomic have been affected. Currently, with no promising treatment for COVID-19, the existing anti-viral drugs and vaccines are the only hope to boost the host immune system to reduce morbidity and mortality rate. Unfortunately, several reports show that people who are partially or fully vaccinated are still susceptible to COVID-19 infection. Evidence suggests that COVID-19 immunopathology may include dysregulation of macrophages and monocytes, reduced type 1 interferons (IFN-1), and enhanced cytokine storm that results in hypersecretion of proinflammatory cytokines, capillary leak syndrome, intravascular coagulation, and acute respiratory distress syndrome (ARDS) ultimately leading to the worsening of patient’s condition and death in most cases. The recent use of cell-based therapies such as mesenchymal stem cells (MSCs) for critically ill COVID-19 patients has been authorized by the Food and Drug Administration (FDA) to alleviate cytokine release syndrome. It protects the alveolar epithelial cells by promoting immunomodulatory action and secreting therapeutic exosomes to improve lung function and attenuate respiratory failure. As a result, multiple clinical trials have been registered using MSCs that aim to use various cell sources, and dosages to promote safety and efficacy against COVID-19 infection. In this review, the possibility of using MSCs in COVID-19 treatment and its associated challenges in their use have been briefly discussed.
The Experience of our Center in Patients Undergoing Insulin Degludec/
Insulin Aspart Co-formulation Therapy
Authors: Altay Feride Pınar , Farzaliyeva Aydan , İyidir Özlem Turhan , Bozkuş Yusuf , Kırnap Nazlı Gülsoy , Kut Altuğ , Nar Aslı , Tütüncü Neslihan Başçıl
Published: November 2022

Aim:

A co-formulation containing insulin degludec and insulin aspart (IDegAsp) is available
for the treatment of diabetes in Turkey. We aimed to evaluate the clinical results of switching to
IDegAsp treatment for Type 2 diabetes.

Method:

A total of 217 patients with type 2 diabetes treated with IDegAsp and having follow-up data were included. The patients were divided into 3 groups. Group 1 switched from basal insulin to IDegAsp, group 2 switched from twice-daily premixed insulin regimen to IdegAsp, and group 3 switched from intensive and thrice-daily premixed insulin regimen to IDegAsp. Groups were evaluated in terms of changes in insulin dose, the number of injections, and changes in HbA1c.

Results:

The mean follow-up period was 7.5 ± 4.4 months. The mean age was 62.8 ± 12.9 years. The
mean duration of diabetes was 15.3 ± 8 years. There was a significant decrease in HbA1c and glucose
(p < 0.0001 and p < 0.0001, respectively). HbA1c was significantly reduced in group 1 (p < 0.0001)
while insulin dose and the number of injections increased (p < 0.0001 and p < 0.0001, respectively).
HbA1c, insulin dose, and the number of injections in group 2 and group 3 (p = 0.001, p = 0.002, p <
0.0001, respectively, and p < 0.0001, p = 0.043, p < 0.0001, respectively) were significantly reduced.

Conclusion:

This study includes real-life experiences involving a remarkable number of patients in
the literature. IDegAsp treatment provided effective blood glucose regulation and caused a significant
decrease in the insulin dose and the number of injections, resulting in increased quality of life
among those who had to receive twice or more insulin injections.
Recent Research on Medical Stent Manufacturing Based on 3D Printing
Technology
Authors: Lu Zikang , Xie Baocheng
Published: November 2022

Background:

With the increasing number of patients with cardiovascular and respiratory
diseases, medical stents are needed to reshape the blood vessels and trachea to restore their function.
Due to its high degree of standardization, the existing medical stent manufacturing technology
is mature and suitable for most groups. However, conventional medical stents are not suitable for
every patient due to the patients’ individual differences and other reasons. Hence, patients need
custom medical stents. Therefore, 3D printing technology with high customization function as an
emerging stent manufacturing method has attracted much attention in recent years.

Objective:

By solving the problem of poor matching rates between traditional medical stents and
human body channels, 3D printing technology will continue to develop in the medical stent manufacturing
field.

Methods:

This study traces the representative patents related to the vascular stent and tracheal stent
manufacturing based on 3D printing technology.

Results:

Through the analysis of numerous patents about 3D printed vascular stents and tracheal
stents, the reasons for the mismatched medical stent specifications and low efficiency are summarized.
The challenges in the development of 3D printing medical stents are discussed.

Conclusion:

Research on the 3D printing of medical stents is conducive to improving patients’
suitability and medical stent implantation and reducing the time cost. More patents will be invented
in the future.
Seismic Performance Assessment of the Historical Reggio Calabria Cathedral
Authors: Brandonisio Giuseppe , Naqash Muhammad Tayyab , Farsangi Ehsan Noroozinejad
Published: November 2022

Background:

Italy's church buildings' cultural and architectural significance cannot be overstated.

Objective:

This paper addresses the seismic vulnerability of the cathedral located in Reggio Calabria, Italy. The analysis of this building is interesting as it was retrofitted after the destructive 1908 Messina-Reggio Calabria earthquake.

Methods:

The original design illustrating the static schemes and the considered actions of the church are described. Structural drawings of that time are also reported, which proved to be fundamental for the numerical modelling of the building. The issues and assumptions made during the modelling phase of the structure with the seismic actions are also illustrated. All the transverse and longitudinal frames were analysed using nonlinear analysis to evaluate the seismic capacity and vulnerability indicators in terms of accelerations and periods.

Results:

The results provided by the modal analysis are presented and discussed to highlight the global dynamic behaviour of the church.

Conclusion:

The seismic vulnerability indicators have been calculated by considering the seismic actions recommended by the current technical standards and concerning the 1975 Messina earthquake, which represents the most severe earthquake experienced by the church.
Fibromyalgia Concomitant with Seropositive Rheumatoid Arthritis in a Tertiary Hospital in South-Western Saudi Arabia: Prevalence and Treatment Patterns
Authors: AlOmair Mohammed , AlMalki Hanan , Sarhan Leen , Shweel Mohammed , Asiri Abdulrahman , Almhjani Eman , Asiri Alhussain , AlQahtani Hanan , Rahman Aydah , Hasan Esraa
Published: November 2022

Introduction:

Rheumatoid arthritis (RA) patients with fibromyalgia syndrome (FMS) report worse functional status and quality of life hence the association has important clinical implications. FMS can be challenging to treat, and the current evidence recommends a multidisciplinary treatment approach focused on symptom management.

Aim:

Information regarding the current prevalence of FMS in RA patients is lacking. Thus, this study aims to address the prevalence and predictors of FMS in seropositive RA patients and demonstrate our clinical practice in the management of FMS.

Methods:

Participants’ data was gathered from Aseer central hospital (ACH) rheumatology clinics and daycare units over a period of 2 years. Subjects were assessed using the 2010 American College of Rheumatology (ACR) criteria for FMS. Data were collected from medical records, including patient demographics, comorbidities and concomitant FMS-related data.

Results:

Out of 310 seropositive RA patients, 15% (n = 47) fulfilled the diagnostic criteria for FMS. Of them, 29, 11 and 7 were on pregabalin, amitriptyline and duloxetine, respectively. Half of FMS patients showed one or more therapy changes. A significant difference between RA patients with and without concomitant FMS was observed, including age, gender and comorbidities.

Conclusion:

In this retrospective study, a high prevalence of FMS in individuals with seropositive RA was identified. This study explores real-world practice in the treatment of FMS with remarkable findings regarding underdosing and lower discontinuation rate of pregabalin.
Effect of Behaviour Change Communication to Prevent Anemia and Hemoglobin Concentration Among Children Growth Age 6 -59 Months In Central Highland Of Ethiopia: Cluster Randomized Control Trial
Authors: Ferede Abebe , Belachew Tefera , Abera Muluemebet
Published: November 2022

Background:

Although, Behavioral Change Communication (BCC) on iron-rich dietary intake rather than iron supplementation trial among individual children is effective. This study aimed to assess the effect of BCC on hemoglobin concentration among the growth of children age 6 to 59 months.

Materials and Methods:

A clustered Randomized Control Trial (CRCT) from February 2017 to April 2019. “Kebeles” (small administration units) were randomly assigned to either the intervention or control clustered arm and sufficient buffer zone made between these clusters to avoid information contamination. Mothers (Care) givers and their index children were selected from each cluster using a simple random sampling technique. Blood samples for Hemoglobin (Hb) were collected from children before and after 15 months of BCC intervention to determine Hb concentration. Descriptive statistics and SPSS - Independent sample T-test and a Generalized Estimating Equations (GEE) models were fitted to isolate independent predictors of hemoglobin concentration.

Results:

At baseline 1012 and end-line 815 mothers and their index children were participated in the study. The mean (±sd) Hbc level was 143g/L+1.6g/L and 148.34 +14.91g/L for the intervention and control groups had 130.73+14.92g/L. The difference of differences in the mean hemoglobin level was 7.69 for the intervention and 3.81 for the control (P=0.001). On the Generalized Estimating Equations analyses model after adjusting for the background variables the intervention group had increased Hbc by 9.93 mg/dl (β=9.93, P <0.05). Similarly, height for age Z-score was positively associated with Hbc mean level (β =7.151, P <0.05).

Conclusions:

The study demonstrated the positive effect of behavior change communication on hemoglobin concentration of children implying the need for the galvanizing efforts to disseminate nutrition behavior change communications to mothers and caregivers of the under five years old children to curb the increasing concern of anemia among these target group.
Assessment of the Accuracy and Inter-Unit Agreement of Ultra-Wide Band to Compute Team Positioning in a Basketball Court
Authors: Rico-González Markel , Arcos Asier Los , Rojas-Valverde Daniel , Pino-Ortega José
Published: November 2022

Background:

Local positioning systems have shown high accuracy for measuring the distance covered and the mean velocities and also for time-motion analysis. However, no study has assessed the accuracy and inter-unit agreement of local positioning system [LPS] technology to compute any collective tactical behavior variable.

Objective:

The main aim of the study was to analyze the accuracy of ultra-wideband and calculate inter-device agreement to compute the geometrical center coordinates (i.e., the relative positioning of each team represented in a single point computed considering x and y coordinates of the players).

Methods:

The inter-device geometrical center agreement of the devices when placed in the corners [static] of a basketball court was also assessed. The geometrical center (x, y coordinates) computed by a local positioning system tool, called an inertial measurement unit, was compared to the known geometrical center position in four different court areas: [1] 15x7 m, [2] 15x14 m [3] 15x21 m [4] 15x28 m. In each of the court areas, two different devices were placed on three tripods [60 cm from the floor] in three corners of the perimeter described. The distance of the device to the reference element was calculated every 0.5 s, providing a total of 600 samples. The absolute difference between the geometrical center measured on the ultra-wideband devices and the real geometrical center was less than 0-1.1%, with an absolute difference of 0 to 0.09 m in all the court areas.

Results:

The difference between the devices when the geometrical center was computed was from 0.14 to 1.36%, with an absolute difference of 0.02 to 0.09 m. The accuracy of the ultra-wide band and inter-device agreement for computing the geometrical center was high (absolute error < 10 cm).

Conclusion:

These findings may suggest future validation protocols of the ultra-wide band for the assessment of collective tactical variables in team sports under a real match or training conditions.
Exploratory Factor Analysis of Match Period and Sex-Related Differences of External and Internal Workload Demands in Youth Basketball Players
Authors: Gutiérrez-Vargas Randall , Ugalde-Ramírez Jose Alexis , Pino-Ortega Jose , Sánchez-Ureña Braulio , Blanco-Romero Luis , Trejos-Montoya Jose , Gutiérrez-Vargas Juan Carlos , Rojas-Valverde Daniel
Published: November 2022

Aims and Scope:

The purpose of this study was to compare external and internal workload according to sex and match periods in youth basketball players during a congested-fixture tournament using an exploratory factor analysis method as a data reduction technique through Principal Component Analysis (PCA).

Methods:

Sixty-four youth basketball players (32 women and 32 men) participated in an official congested-fixture tournament of three consecutive matches. An ultra-wideband (UWB) indoor and inertial measurement unit (IMU) was used to quantify external and internal workload. PCA identified six to seven principal components that explained more than 60% and 70% of the variance for men and women, respectively. Significant differences between sexes in the external load variable as AccMax, DecMax, AccAvg, DecAvg, Acc2–4 /min, Dec2–4 /min, Sprint/min, SpeedMax, JumpsTotal, JumpsAvg, Takeoff3–5g /min, and Takeoff5–8g /min; and internal load variables as Player Load, Power Met, and Heart Rate bpm. TD/min, AccAvg /min, DecAvg /min, Acc2–4 /min, and Dec2–4 /min decreased significantly throughout the match.

Result:

The results indicated that acceleration and deceleration greater explained men locomotion while jumping actions had higher significance in women. Monitoring youth basketball competition is useful for understanding physical and physiological individual and collective demands.

Conclusion:

Statistical data reduction techniques are also sensitive to detect potential sex-related differences.
Risk Prediction of Type 2 Diabetes Mellitus (T2DM) in Indian Families
Using Antioxidant Gene Variants
Authors: Banerjee Monisha , Kushwah Atar Singh , Vats Pushpank , Usman Kauser
Published: November 2022

Background:

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease
that is caused by insulin dysfunction. It is an output of oxidative stress that results from defective
redox reactions and increased reactive metabolites (RMs) and is neutralized by antioxidant
enzymes. It has been reported that decreased levels of antioxidant enzymes are due
to genetic alterations in the respective genes. Therefore, the present study has undertaken a
genetic analysis of antioxidant genes and their interaction in the family to assess T2DM
risk.

Objective:

This study aimed to investigate the individual susceptibility/risk to T2DM using
antioxidant gene variants and their interactions in family members with a diabetic history.

Methods:

Genotypic analysis of antioxidant genes was done by polymerase chain reactionrestriction
fragment length polymorphism (PCR-RFLP), haplotype analysis, and gene-gene
interactions using statistical tools. Pedigrees were constructed by face-to-face interviews
with members of nine families.

Results:

Genotypes AT (CAT-21A>T), IV (GSTP1+313(105I>V), and CT (GPx1
+599C>T) were found to be frequent in diabetic individuals. For instance, in one family, if
only the mother had diabetes, all siblings were found to have the risk genotypes AT (CAT-
21A>T) and CT (GPx1 +599C>T) with 2.12- and 2.11-folds risk of developing T2DM. The
risk haplotypes, NNV (GSTM1 N>P(Null>Present), GSTT1 N>P(Null>Present),
GSTP1105I>V and TCC (CAT-21A>T, SOD2+47C>T, GPx1+599C>T) were observed in
most of the diabetic individuals and non-diabetics possessing the risk haplotypes manifested
altered BMI.

Conclusion:

The present study suggests that the GSTP1105I>V, CAT-21A>T,
SOD2+47C>T and GPx1+599C>T gene variants can be prognostic biomarkers for the assessment
of T2DM risk in healthy individuals.
Punica granatum Peel Waste - An Underutilized Substrate of Therapeutic
Potential: An Overview
Authors: Noor Uroosa , Soni Shashi , Gupta Ena
Published: November 2022

India is the second largest consumer and producer of fruits globally. It leads to ample
solid waste per year from fruit processing industries that have been proven hazardous to the surroundings.
Punica granatum (Pomegranate) belongs to the Lythraceae subfamily Punicoideae,
which exhibits immense nutritional properties and delicious flavoring components. The weight
of this fruit mainly consists of peel, i.e., 50%, followed by 40% of arils and 10% of seeds. Thus,
the major byproduct is peel that holds many valuable bioactive compounds in higher concentrations
viz saponins, carotenoids, steroids, polyphenols, quercetin derivatives, caffeic acid, phenolic
acids, flavonoids, ellagitannins, p-coumaric acid, chlorogenic acid, quinic acid, anthocyanidins,
triterpenoids, glycosides, tannins, and many more. Consequently, it results in wideranging
therapeutic applications, including antioxidative, anti-microbial, antihypertensive, anticarcinogenic,
anti-genotoxic, anti-inflammatory, glucoregulation, cardio-protective, hepatoprotective
and nephroprotective effects along with prebiotic potential. Considering their nutritional
and therapeutic aspects, these peels can be used for many purposes rather than being disposed
off. With a value-added approach, it is utilized in many food and non-food sectors. So, this
review aims to explore the therapeutic potential of P. granatum peel and enlighten its diverse applications
in the food industry.
Path Difference and Its Difference Function
Authors: Yu Tao
Published: November 2022

This chapter is the most important one in this monograph. In this chapter,
a detection method for phase change rate without phase ambiguity is presented. The
results of this study lay a foundation for the realization of unambiguous phase
difference localization. First, based on the functional relationship between the
distance change rate and the phase shift change rate, the phase difference
measurement method of the phase shift change rate is given through the difference
approximation of the distance change rate. Then, the expression of phase difference
change rate based on the multi-channel phase difference measurement is obtained by
using the phase difference measurement of phase shift change rate and differential
processing by phase differential rate of change. On this basis, by stripping the time
difference term corresponding to the baseline length from the change rate of phase
difference, a function representing the different characteristics of the number of
wavelengths and the phase difference per unit wavelength length is extracted. The
subsequent simulation results show that the variation of the difference function of
path difference per unit wavelength length is very regular. The corresponding
correction number can be determined directly by distinguishing the range of
difference of phase difference, and the range is obtained by the actual measurement.
A function expression can be obtained independent of the difference term of the
integer of wavelengths as well as equivalent to the difference function of path
difference. Finally, the problem of nonfuzzy phase difference measurement for path
difference is briefly described. These research results undoubtedly provide a powerful
technical support for the practical design of engineering related to phase
measurement.
Clinical Decision Support System for Early Prediction of Congenital Heart Disease using Machine learning Techniques
Authors: Aggarwal Ritu , Kumar Suneet
Published: November 2022

One of the main reasons for deaths in children or low-age kids is congenital heart disease detected by CDSS (clinical decision support system). If it's diagnosed at an early stage, the significant results can be obtained for life-saving. The practitioners are not equally qualified and skilled so the detection of the disease and the proper diagnosis is delayed. The best prevention is the early detection of the symptoms of this disease. An automated medical diagnosis system is made to improve the accuracy and diagnose the disease. CHD expands the heart deformation as in newborn babies. Early detection of CHD is necessary to detect and diagnose this disease. Due to this, the life of a newborn child is in danger. By different detection methods, CHD could be accomplished by its clinical information using CDSS and it is also detected by its nonclinical data. In pregnant ladies, CHD is diagnosed by their non-clinical data by applying it to the newborn baby that is in their womb. Due to this, different machine learning algorithms, including K-NN and MLP, are explored. For CHD detection, dataset selection is a big issue, and it is utilized by the Support Vector Machine and random forest, K-NN, and MLP algorithms. This proposed work develops a decision support system to detect congenital heart disease. In this proposed work, the data mining techniques and the machine learning algorithms are used to gain insight into the system for their accuracy rate. This proposed work is designed and developed by the Python jupyter notebook to implement MLP. This paper presents an analysis using the machine learning algorithm to develop an accurate and efficient model for heart disease prediction. The MLP models have a high accuracy of 97%.
Malign Influence Operations in Narrative Warfare
Authors: Daniele John
Published: November 2022

On July 21, 2022, John Daniele, the Managing Director of DNC Cybersecurity and President of Progressive World Federalists, presented on Malign Influence Operations in Narrative Warfare. Following the presentation, a question-and-answer period ensued wherein questions were collected from the audience and CASIS-Vancouver executives. The major points discussed throughout the event included how malign influence manipulates public opinion and causes social disruption; the key tools used in this form of persuasion; the online network effect of operations that involve fake accounts and state-sponsored trolling; and possible solutions to malign influence operations.
MAD* Beyond Defence
Authors: Adlakha-Hutcheon Gitanjali
Published: November 2022

Advancements in technology are regularly identified, assessed, and classed into emerging and/or potentially disruptive technologies, according to their ability to cause disruptions to defence systems, and in defence. Perhaps this is because defence capabilities centre on grand technology systems deployed at the level of nations. Hypersonic missiles are one example. The testing of a new hypersonic missile or a research program on types of hypersonic drones immediately sparks questions like: which other nations have such capability? or what types of technologies can be used to detect or counter these? In contrast, the ability to identify weak, faint factors that add up and lead to conflict are not brought together in a systematic manner. Nor is it common for there to be a cross-talk between a combination of methods used within military science and technology organizations over in to social sciences related to intelligence and/or conflict. This is a preventable strategic foresight issue relevant for enhancing, planning for, and investing in the security space. This paper describes the MAD (Methodology for Assessing Disruptions) tool, which is adaptable beyond the defence domain. MAD is a scenario-based two-part table-top exercise conducted to identify weak signals that have the potential to cause disruptions, which by consequence may coalesce into challenges for security. Exercising such methods is essential for security professionals to prepare and plan for future conflicts instead of constantly reacting to immediate acute problems.
Narrativas terminais
Authors: Françoli Yago Daniel
Published: November 2022

Este artigo teve como objetivo refletir sobre elementos críticos da imaginação em relação ao fim do mundo no contexto pandêmico. Para tanto, partiu-se da ideia de que há uma terminalidade inerente as nossas narrativas temporais sobre o mundo que determina tanto sua caducidade quanto nossa obsessão pelo fim. O artigo foi dividido em quatro tópicos: no primeiro, exploramos o fim do mundo pelas lentes da catástrofe, relação quase que mandatória atualmente, a fim de entender nossas implicações como produtos e produtores dessa ordem de fantasia; no segundo e terceiro tópicos, abordamos a construção simbólica e política de uma ordem de tempo terminal a que chamamos de Modernidade, com particular atenção ao ponto de vista decolonial; e, no último tópico, refletimos sobre nossa responsabilidade, como psicólogas e psicólogos, para com o atravessamento das ideias de fim de mundo. O artigo utilizou levantamento bibliográfico de publicações nas áreas da psicologia analítica, filosofia e teoria decolonial e, à maneira de um ensaio, pautou-se por um compromisso mais com as interrogações levantadas do que com eventuais respostas.
Recycled Wastewater Usage: A Comprehensive Review for Sustainability of Water Resources
Authors: Chand Jeet , Jha Shiva , Shrestha Sameer
Published: November 2022

Water recycling is a potential tool for reducing the dependency on traditional water sources, which would eventually reduce the likelihood of volumetric restrictions and their impacts on the water sector. Therefore, exploration, development, and use of alternative water sources are required for sustainable development. Scientific studies on the efficient and economical use of nontraditional water sources developed using the recycling process have attracted the attention of agriculturists, planners, and engineers for the last two decades. Recycled wastewater types, including greywater, sewage, stormwater, and industrial wastewater, have been discussed in this study. This article reviewed various forms of recycled wastewater, especially wastewater from treated sewage, and their effects on human health and irrigated environment. In addition, the necessity of exploration and usage of alternative sources of water in agriculture over traditional sources has also been reviewed. Legislations and guidelines of three major countries regarding the water recycling process and subsequent use have also been presented. The key finding of this article is that the agriculture and water recycling industry can only be connected sustainably when recycled wastewater complies with agronomical, environmental, and sanitary requirements. Because of the rapid advancements in wastewater recycling technologies, water recycling and recycled water usage have great potential to manage the increasing burden on freshwater resources. Finally, the sustainable use of recycled wastewater is crucial to minimize the negative effects on agriculture, the environment, and human health.
Accuracy of Augmented Reality–Assisted Navigation in Dental Implant Surgery: Systematic Review and Meta-analysis
Authors: Mai Hang-Nga , Dam Van Viet , Lee Du-Hyeong
Published: November 2022

Background

The novel concept of immersive 3D augmented reality (AR) surgical navigation has recently been introduced in the medical field. This method allows surgeons to directly focus on the surgical objective without having to look at a separate monitor. In the dental field, the recently developed AR-assisted dental implant navigation system (AR navigation), which uses innovative image technology to directly visualize and track a presurgical plan over an actual surgical site, has attracted great interest.

Objective

This study is the first systematic review and meta-analysis study that aimed to assess the accuracy of dental implants placed by AR navigation and compare it with that of the widely used implant placement methods, including the freehand method (FH), template-based static guidance (TG), and conventional navigation (CN).

Methods

Individual search strategies were used in PubMed (MEDLINE), Scopus, ScienceDirect, Cochrane Library, and Google Scholar to search for articles published until March 21, 2022. This study was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database. Peer-reviewed journal articles evaluating the positional deviations of dental implants placed using AR-assisted implant navigation systems were included. Cohen d statistical power analysis was used to investigate the effect size estimate and CIs of standardized mean differences (SMDs) between data sets.

Results

Among the 425 articles retrieved, 15 articles were considered eligible for narrative review, 8 articles were considered for single-arm meta-analysis, and 4 were included in a 2-arm meta-analysis. The mean lateral, global, depth, and angular deviations of the dental implant placed using AR navigation were 0.90 (95% CI 0.78-1.02) mm, 1.18 (95% CI 0.95-1.41) mm, 0.78 (95% CI 0.48-1.08) mm, and 3.96° (95% CI 3.45°-4.48°), respectively. The accuracy of AR navigation was significantly higher than that of the FH method (SMD=−1.01; 95% CI −1.47 to −0.55; P<.001) and CN method (SMD=−0.46; 95% CI −0.64 to −0.29; P<.001). However, the accuracies of the AR navigation and TG methods were similar (SMD=0.06; 95% CI −0.62 to 0.74; P=.73).

Conclusions

The positional deviations of AR-navigated implant placements were within the safety zone, suggesting clinically acceptable accuracy of the AR navigation method. Moreover, the accuracy of AR implant navigation was comparable with that of the highly recommended dental implant–guided surgery method, TG, and superior to that of the conventional FH and CN methods. This review highlights the possibility of using AR navigation as an effective and accurate immersive surgical guide for dental implant placement.
Nghiên cứu thuật toán thị giác máy tính để theo dõi việc thực hiện các quy định về phòng ngừa Covid-19 sử dụng kỹ thuật học sâu
Authors: Nguyễn Đức Thiện , Lư Tất Thắng , Nguyễn Văn Thặng , Trương Quốc Bảo
Published: November 2022

Bài báo này được thực hiện nhằm nghiên cứu phát hiện và kiểm tra việc tuân thủ các quy định về đeo khẩu trang, giữ khoảng cách xã hội ở các địa điểm đông đúc. Mô hình YOLO được sử dụng để xây dựng thuật toán phát hiện đeo khẩu trang đúng hay không đúng quy định, đồng thời kiểm tra việc giữ khoảng cách xã hội bằng việc sử dụng thuật toán tính khoảng cách Euclid giữa các khung bao quanh người được phát hiện trong hình ảnh, kết hợp thuật toán chuyển đổi Bird’s-eye view. Tập dữ liệu được sử dụng bao gồm 40 hình ảnh với hai đối tượng người được phân loại thực tế theo khoảng cách đứng với nhau: lớn hơn hoặc bằng 2 m và nhỏ hơn 2 m. Đồng thời, mỗi đối tượng người trong hình ảnh được phân loại thành ba lớp: đeo khẩu trang đúng hay không đúng và không đeo khẩu trang. Kết quả thử nghiệm khoảng cách đối tượng đạt 90% và nhận diện đối tượng đeo khẩu trang có kết quả như sau: 86,67% đeo khẩu trang đúng, 76,67%  không đeo khẩu trang và 65% đeo khẩu trang...
Tình hình học cùng lúc hai chương trình của sinh viên Trường Đại học Cần Thơ trong giai đoạn hiện nay
Authors: Huỳnh Thị Thanh Hường , Nguyễn Thị Như Ý , Châu Minh Phát
Published: November 2022

Bài viết trình bày nghiên cứu về tình hình học cùng lúc hai chương trình của sinh viên (SV) tại Trường Đại học Cần Thơ. Được sử dụng trong bài viết, các phương pháp thực nghiệm bao gồm phỏng vấn bằng phiếu khảo sát cấu trúc và bán cấu trúc 31 SV đang học song ngành tại trường. Kết quả nghiên cứu cho thấy SV nhận thức được lợi ích của việc học song ngành có thể mang lại. Song, nhiều SV cho biết bản thân còn gặp khó khăn khi học song ngành, do đó SV có nhu cầu nhận hỗ trợ nhiều hơn từ phía nhà trường. Trên cơ sở lí luận của nghiên cứu, một số đề xuất được đưa ra nhằm tạo điều kiện thuận lợi hơn cho SV tham gia học song ngành tại Trường Đại học Cần Thơ.
Xây dựng chùm cho dữ liệu ảnh từ khoảng hai chiều được trích xuất
Authors: Võ Văn Tài , Lê Thị Kim Cương , Châu Ngọc Thơ
Published: November 2022

Nhận dạng ảnh có vai trò rất quan trọng trong cuộc cách mạng số hiện nay vì nó là nền tảng của nhiều ứng dụng thực tế. Nghiên cứu này đề nghị việc nhận dạng ảnh bởi khoảng hai chiều được trích xuất từ đặc trưng kết cấu. Dựa vào khoảng cách chồng lấp và đặc trưng khoảng được trích xuất, một thuật toán phân tích chùm mờ cho ảnh được đề nghị. Thuật toán này có thể xác định số chùm thích hợp phải chia cho một tập ảnh, những ảnh cụ thể trong mỗi chùm và xác suất thuộc vào các chùm của mỗi ảnh. Thuật toán đề nghị được trình bày chi tiết từng bước về mặt lý thuyết và được minh hoạ bởi ví dụ số. Thực hiện trên một tập ảnh cụ thể, thuật toán đề nghị đã cho kết quả tốt nhất trong so sánh với các thuật toán gần đây. Nghiên cứu này có thể triển khai cho nhiều vấn đề thực tế liên quan đến nhận dạng ảnh.
Nghiên cứu tạo phôi chuột knockout gene lep sử dụng kỹ thuật CRISPR/Cas9
Authors: Âu Dương Tuyết Mai , Nguyễn = Lê Trâm Anh , Nguyễn Thị Thanh Giang , Huỳnh Chí Thiện , Phạm Minh Chiến , Huỳnh Nguyễn Loan Anh , Nguyễn Đăng Quân
Published: November 2022

Kỹ thuật CRISPR/Cas 9 đang được sử dụng nhiều trong công nghệ chỉnh sửa gene. Trong nghiên cứu này, phôi chuột knockout gene Lep được tạo ra bằng cách vi tiêm plasmid có cấu trúc CRISPR/Cas9 hướng đến exon 3 của gene. Các phần mềm tin sinh học thiết kế 2 gRNA được sử dụng và tạo dòng được plasmid px330-gRNA-R và px330-gRNA-L có khả năng định hướng giúp hệ CRISPR/Cas9 loại bỏ đoạn exon 3 có chiều dài 420bp, ở vị trí 29070816 – 29071236 trên gene Lep. Phôi chuột được tạo ra bằng phương pháp bơm tinh trùng vào bào tương trứng (ICSI). Sau 6 h ICSI (Intra-Cytoplasmic Sperm Injection), phôi chuột ở giai đoạn hợp tử hai tiền nhân, được knockout gene bằng cách vi tiêm plasmid px330-gRNA-R và px330-gRNA-L với nồng độ 5 ng/µl vào tiền nhân đực. Kết quả kiểm tra PCR các phôi có vi tiêm plasmid cho thấy 36/72 (50%) phôi đã được loại bỏ đoạn exon 3 gene Lep. Như vậy, nghiên cứu đã tạo thành công phôi knockout gene Lep ở dạng dị hợp.
Phát hiện bất thường: dự đoán khung hình tương lai kết hợp sota optical-flow model và cải tiến hàm lỗi dựa trên FenceGan
Authors: Võ Trung Hiếu , Vo Duy Nguyen , Nguyễn Tấn Trần Minh Khang
Published: November 2022

Phát hiện bất thường là một bài toán được quan tâm nhiều trong những năm gần đây với nhiều phương pháp ra đời có độ chính xác cao. Future Frame Prediction là phương pháp tiếp cận mới lạ đối với bài toán phát hiện bất thường trong video. Phương pháp này có ý tưởng chính là sử dụng các video chỉ chứa khung hình bình thường để huấn luyện mô hình. Giai đoạn kiểm tra, mô hình có thể nhận đầu vào là video có chứa khung hình bất thường, việc phát hiện bất thường dựa trên sự khác biệt giữa khung hình được tái tạo từ dữ liệu bình thường và khung hình thực tế có chứa bất thường trong video kiểm tra. Trong bài báo này, mô hình được cải thiện bằng cách thay đổi thành phần ước lượng optical-flow trong mô hình Future Frame Prediction và sửa đổi hàm lỗi dựa trên công trình FenceGAN nhằm tăng hiệu suất phát hiện bất thường. Kết quả sau khi tinh chỉnh, mô hình cải thiện độ chính xác trung bình 0,5% trên các bộ dữ liệu chuẩn như UCSD Ped1, UCSD Ped2, Avenue.