bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Oral Flora with Orbital Complications of Acute Sinusitis
Authors: Flam Juliette O. , Platt Michael P. , Sobel Rachel , Devaiah Anand K. , Brook Christopher D.
Published: July 2016

Background

Acute and chronic sinusitis in children and adults can spread to the orbit. Oral flora has been seen in orbital infections, but the extent of synergy between pathogens in such infections remains unknown.

Methods

A retrospective case series of patients with complicated sinusitis that involved the orbit from acute sinusitis who were admitted to a tertiary care hospital from January 2000 to December 2014 and who had surgical cultures obtained. Patients were identified by the International Classification of Diseases, Ninth Revision code for periorbital cellulitis, subperiosteal abscess, or orbital abscess.

Results

Sixteen patients underwent surgical drainage via external drainage or endoscopic sinus surgery of an orbital infection associated with sinusitis and had cultures obtained. Nine patients (56%) grew organisms that exist in oral flora, whereas seven patients (44%) grew common respiratory pathogens. The most common organisms recovered were viridans group streptococcus (VGS) (50%), Staphylococcus aureus (31%), Eikenella corrodens (25%), and Prevotella species (19%). Oral flora anaerobes were cultured alongside a VGS species in seven of eight patients (88%) as opposed to the respiratory pathogens, which were less frequently associated with concomitant VGS infection (29%) (p = 0.04).

Conclusion

There are two main sources for infectious orbital complications from acute sinusitis: respiratory pathogens and oral flora. The high prevalence of concurrent anaerobic oral flora and VGS infection supports a suspected synergy between VGS and other oral organisms.
Wogonin Inhibits Transforming Growth Factor β1–induced Extracellular Matrix Production via the p38/activator Protein 1 Signaling Pathway in Nasal Polyp–derived Fibroblasts
Authors: Ryu Nam Hyoung , Shin Jae-Min , Um Ji-Young , Park Il-Ho , Lee Heung-Man
Published: July 2016

Background

Wogonin has been shown to have antifibrotic and anti-inflammatory effects in the lower airway. The purpose of this study was to evaluate the effects of wogonin on transforming growth factor (TGF) β1–induced myofibroblast differentiation, extracellular matrix production, migration, and collagen contraction, and to determine the molecular mechanisms of wogonin in nasal polyp–derived fibroblasts (NPDF).

Methods

NPDFs were isolated from nasal polyps from eight patients. TGF-β1–induced NPDFs were treated with wogonin. Cytotoxicity was evaluated by using a 3-(4,5- dimethylthiazol-2yl)-2,5-diphenyl-tetrazolium bromide assay. Fibroblast migration was evaluated with transwell and scratch migration assays. The expression levels of α-smooth muscle actin, fibronectin, phosphorylated-p38, and c-Fos were determined by Western blot and/or reverse transcription–polymerase chain reaction. The total collagen amount was analyzed with the Sircol collagen assay, and contractile activity was measured by a collagen gel contraction assay.

Results

Wogonin (0–60 μM) had no significant cytotoxic effects on TGF-β1–induced NPDFs. Migration of NPDFs was significantly inhibited by wogonin treatment. The expression levels of α-smooth muscle actin and fibronectin were significantly reduced in wogonin-treated NPDFs. Collagen production and contraction were also significantly decreased by wogonin treatment. Wogonin markedly inhibited activation of the p38/activator protein 1 pathway in TGF-β1–induced NPDFs.

Conclusion

These results indicated that wogonin may inhibit TGF-β–induced myofibroblast differentiation, extracellular matrix production, migration, and collagen contraction through the p38/activator protein-1 pathway in NPDFs.
Intact Soluble P-Glycoprotein is Secreted by Sinonasal Epithelial Cells
Authors: Nocera Angela L. , Meurer Ana T. , Singleton Amy , Simons Christopher , BuSaba Joseph , Gass Nicole Tara , Han Xue , Bleier Benjamin S.
Published: July 2016

Background

P-glycoprotein (P-gp) is a 170 kDa transmembrane efflux pump, which is upregulated in chronic rhinosinusitis. Studies of leukemia demonstrated that P-gp may also be secreted in an intact soluble form. The purpose of this study was to explore whether sinonasal epithelial cells were capable of secreting soluble P-gp and whether P-gp has any functional role.

Methods

Soluble and cytoplasmic P-gp were quantified in vehicle and lipopolysaccharide exposed cultures by enzyme-linked immunosorbent assay. The molecular weight of the soluble P-gp was determined by Western blot. Naive cultures were exposed to recombinant human P-gp at 0-2000 ng/mL. The degree of membranous interpolation was determined by quantitative fluorescent immunocytochemistry and function was determined by a calcein acetoxymethyl ester assay.

Results

Soluble P-gp was secreted intact at 170 kDa. Mean (standard deviation) secretion was detected within vehicle wells at 55.43 ± 26.26 ng/mL, which significantly increased to 333.27 ± 305.98 ng/mL (p < 0.001) after lipopolysaccharide stimulation. Soluble P-gp strongly and significantly correlated with cytoplasmic P-gp (r = 0.57, p = 0.000001). Exposure to 2000 ng/mL of recombinant P-gp significantly increased corrected total cell fluorescence (1.34 ± 1.85) relative to vehicle control 0.29 ± 0.26 (p = 0.01) and significantly reduced calcein acetoxymethyl ester fluorescence (82.03 ± 43.69) relative to 100 ng/mL recombinant P-gp exposed cells (123.11 ± 42.16, p = 0.001).

Conclusion

Cultured sinonasal epithelial cells were able to both secrete intact P-gp and could functionally interpolate soluble P-gp into their cell membrane. These in vitro findings indicated that soluble P-gp may be present in nasal mucus as a biomarker and could participate in the maintenance of P-gp overexpression in chronic rhinosinusitis and associated inflammation.
In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology
Authors: Hariri Benjamin M. , Payne Sakeena J. , Chen Bei , Mansfield Corrine , Doghramji Laurel J. , Adappa Nithin D. , Palmer James N. , Kennedy David W. , Niv Masha Y. , Lee Robert J.
Published: July 2016

Background

T2R bitter taste receptors play a crucial role in sinonasal innate immunity by upregulating mucociliary clearance and nitric oxide (NO) production in response to bitter gram-negative quorum-sensing molecules in the airway surface liquid. Previous studies showed that phytochemical flavonoid metabolites, known as anthocyanidins, taste bitter and have antibacterial effects. Our objectives were to examine the effects of anthocyanidins on NO production by human sinonasal epithelial cells and ciliary beat frequency, and their impact on common sinonasal pathogens Pseudomonas aeruginosa and Staphylococcus aureus.

Methods

Ciliary beat frequency and NO production were measured by using digital imaging of differentiated air-liquid interface cultures prepared from primary human cells isolated from residual surgical material. Plate-based assays were used to determine the effects of anthocyanidins on bacterial swimming and swarming motility. Biofilm formation and planktonic growth were also assessed.

Results

Anthocyanidin compounds triggered epithelial cells to produce NO but not through T2R receptors. However, anthocyanidins did not impact ciliary beat frequency. Furthermore, they did not reduce biofilm formation or planktonic growth of P. aeruginosa. In S. aureus, they did not reduce planktonic growth, and only one compound had minimal antibiofilm effects. The anthocyanidin delphinidin and anthocyanin keracyanin were found to promote bacterial swimming, whereas anthocyanidin cyanidin and flavonoid myricetin did not. No compounds that were tested inhibited bacterial swarming.

Conclusion

Results of this study indicated that, although anthocyanidins may elicited an innate immune NO response from human cells, they do not cause an increase in ciliary beating and they may also cause a pathogenicity-enhancing effect in P. aeruginosa. Additional studies are necessary to understand how this would affect the use of anthocyanidins as therapeutics. This study emphasized the usefulness of in vitro screening of candidate compounds against multiple parameters of both epithelial and bacterial physiologies to prioritize candidates for in vivo therapeutic testing.
Comparison of the Aesthetic Results of Two Common Incisions in External Rhinoplasty: A Randomized Trial
Authors: Saedi Babak , Amali Amin , Taibnama Narges , Most Sam P.
Published: July 2016

Objective

To compare the scar outcomes of two common incisions (inverted V and stair step) by using a validated scar-outcome instrument via a randomized clinical trial.

Methods

Fifty-eight consecutive cases of external rhinoplasty were randomly divided into two groups according to the type of incision. These patients were followed-up for 1 year, and the columellar scar was analyzed by using the Stony Brook Scar Evaluation Scale (SBSES) and visual analog scale (VAS) scores by an independent reviewer.

Results

Of 58 patients, 28 received the inverted V and the rest received the stair-step incision. Thirty-four participants (58.6%) were women. The mean (standard deviation) age of the participants was 26.2 ± 6.6 years. After 1 month, the scar outcome was significantly better in patients with the stair-step incision (p = 0.001) by using the SBSES, but the same was not true after 1 year (p = 0.425). However, when the VAS instead of the SBSES was used to evaluate the scar, the inverted V received a better score after 12 months in this series (p = 0.005).

Conclusion

Despite the better aesthetic outcome of the stair-step incision in the first month after the surgery, there was no significant difference between the two incisions after 1 year. However, in this series, when the VAS instead of the SBSES was used to evaluate the scar, the inverted V received a better score after 12 months.
Temporal Differences in Improvement of Nasal Obstruction between Primary and Revision Septoplasty
Authors: Jeong Jong In , Hong Sang Duk , Kim Su Jin , Dhong Hun-Jong , Chung Seung-Kyu , Kim Hyo Yeol
Published: July 2016

Background

Septoplasty is one of most frequently performed surgeries in otorhinolaryngologic clinics to improve nasal obstruction by correcting nasal septal deformities. Many patients require revision surgery for persistent nasal obstruction. However, the outcomes and sources of revision septoplasty are unclear.

Objective

We investigated the discrepancy between patient's subjective and objective improvements after septoplasty by comparing primary and revision procedures.

Methods

Patients who underwent septoplasty from January 2012 to December 2014 were enrolled. All the subjects were questioned regarding subjective nasal symptoms before surgery and 1 month and every 3 months after surgery, with responses rated on a 7-point Likert scale. Nasal endoscopic evaluation and acoustic rhinometry were also performed with the same schedule.

Results

One hundred seventy-nine patients were analyzed. Subjective nasal obstruction scores of both the primary (n = 161) and revision (n = 18) groups were significantly improved at 1 month after surgery and showed no difference between the two groups. However, this improvement was sustained to the last follow-up only in the primary group. The symptom improvement rate of the primary group (85.5% [n = 109]) was significantly higher than that of the revision group (58.8% [n = 10]) at the last follow-up. There was no difference in the degree of improvement in objective findings between the two groups, including the difference and the ratio of the minimal cross-sectional area between the wider and narrower sides, and in endoscopic findings, even at the last follow-up.

Conclusion

Compared with primary septoplasty, the long-term efficacy of revision septoplasty may not be clear, and there are discrepancies between the subjective and objective outcomes.
Sinonasal Polyposis in the Elderly
Authors: Brescia Giuseppe , Barion Umberto , Pedruzzi Barbara , Cinetto Francesco , Giacomelli Luciano , Pendolino Alfonso Luca , Marino Filippo , Manzato Enzo , Martini Alessandro , Marioni Gino
Published: July 2016

Background/Objective

The main end point of this investigation was to review our experience gained from 2009 to 2015 of treating chronic rhinosinusitis with nasal polyps (CRSwNP) in elderly patients (≥65 years old) with functional endoscopic sinus surgery. Secondary aims were to analyze the prognostic variables for CRSwNP in elderly patients and to compare the demographic, clinical, laboratory, histologic, and prognostic characteristics of CRSwNP in elderly versus young adult patients (20-40 years old).

Methods

Forty-three consecutive elderly patients and 71 consecutive young adult patients with CRSwNP were enrolled.

Results

Significant associations were found in the elderly group between CRSwNP recurrence and allergy (p = 0.037), CRSwNP recurrence and asthma (p = 0.017), and CRSwNP recurrence and acetyl salicylic acid (ASA) intolerance (p = 0.032) but not between recurrence and eosinophilic/noneosinophilic CRSwNP histology. Significant associations emerged in the young adult group between CRSwNP recurrence and asthma (p = 0.009), and ASA intolerance (p = 0.016), and serum eosinophil count (p = 0.02). The recurrence rate was also significantly higher for young adult patients with eosinophilic-type CRSwNP (p = 0.001). CRSwNP recurred less often in the elderly than in the young adult patients (p = 0.05).

Conclusion

The present preliminary investigation found a lower recurrence rate after functional endoscopic sinus surgery for CRSwNP in elderly patients than in young adult patients. Further investigations on larger, prospective series are mandatory to support the hypothesis that, although eosinophilic-type CRSwNP is generally considered a variant at high risk of recurrence and that probably warrants stricter postoperative follow-up and adjuvant postoperative medical treatment, these considerations could not be applied to elderly patients.
Person Fit Analysis in Computerized Adaptive Testing Using Tests for a Change Point
Authors: Sinharay Sandip
Published: July 2016

Meijer and van Krimpen-Stoop noted that the number of person-fit statistics (PFSs) that have been designed for computerized adaptive tests (CATs) is relatively modest. This article partially addresses that concern by suggesting three new PFSs for CATs. The statistics are based on tests for a change point and can be used to detect an abrupt change in test performance of examinees during a CAT. The Type I error rate and power of the statistics are computed from a detailed simulation study. The performances of the new statistics are compared with those of four existing PFSs using receiver operating characteristics curves. The new statistics are then computed using data from an operational and high-stakes CAT. The new PFSs appear promising for assessment of person fit for CATs.
Understanding Consumer Preferences for Australian Sparkling Wine vs. French Champagne
Authors: Culbert Julie , Verdonk Naomi , Ristic Renata , Olarte Mantilla Sandra , Lane Melissa , Pearce Karma , Cozzolino Daniel , Wilkinson Kerry
Published: July 2016

Sparkling wine represents a small but significant proportion of the Australian wine industry’s total production. Yet, Australia remains a significant importer of French Champagne. This study investigated consumer preferences for Australian sparkling wine vs. French Champagne and any compositional and/or sensorial bases for these preferences. A range of French and Australian sparkling wines were analyzed by MIR spectroscopy to determine if sparkling wines could be differentiated according to country of origin. A subset of wines, comprising two French Champagnes, a French sparkling wine and three Australian sparkling wines, were selected for (i) descriptive analysis to characterize their sensory profiles and (ii) acceptance tests to determine consumer liking (n = 95 Australian wine consumers). Significant differences were observed between liking scores; on average, the $70 French Champagne was liked least and the $12 Australian sparkling wine liked most, but segmentation (based on individual liking scores) identified clusters comprising consumers with distinct wine preferences. Interestingly, when consumers were shown wine bottle labels, they considered French wines to be more expensive than Australian wines, demonstrating a clear country of origin influence.
Simple Process for Sidewall Modification of Multi-Walled Carbon Nanotubes with Polymer Side Chain Radicals Generated by Ultraviolet-Induced C–Cl Bond Dissociation of Polystyrene Derivatives
Authors: Takada Tomoya , Baba Takuma , Abe Shigeaki
Published: July 2016

In this work, we investigated a simple one-step process for the formation of chemical bonds between multi-walled carbon nanotubes (MWCNTs) and benzyl-type side chain radicals generated by UV photolysis of polystyrene derivatives containing the chloromethyl (–CH2Cl) group. Poly(4-chloromethyl)styrene, or styrene/4-(chloromethyl)styrene random copolymer, was mixed with MWCNTs in 1-methyl-2-pyrrolidone and irradiated with ultraviolet (UV) light. Films of polymer/MWCNT mixtures before and after UV irradiation were fabricated, and then examined by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. According to the XPS analysis, the amount of Cl atoms in the mixture was found to decrease upon UV irradiation, indicating that the Cl atoms generated by photolysis of chloromethyl groups escaped from the reaction system in the form of gaseous Cl2. The structural change of CNTs after UV irradiation was also observed by comparing the G/D ratios (the intensity ratio of the G to D bands) of the Raman spectra obtained before and after UV irradiation. Similar phenomena were also confirmed in the case of the polymer/MWCNT mixture containing hydroxylammonium chloride as a dispersant of MWCNTs. These results confirmed the UV-induced covalent bond formation between polymer side chains and MWCNTs.
Maximum Power Point Tracking Sensorless Control of an Axial-Flux Permanent Magnet Vernier Wind Power Generator
Authors: Luo Xiang , Niu Shuangxia
Published: July 2016

Recently, Vernier permanent magnet (VPM) machines, one special case of magnetic flux-modulated (MFM) machines, benefiting from their compact, simple construction and low-speed/ high-torque characteristics, have been receiving increasing interest. In this paper, the Vernier structure is integrated with an axial-flux PM machine to obtain the magnetic gear effect and produce an improved torque density for direct-drive wind power generation application. Another advantage of the proposed machine is that the stator flux rotating speed can be relatively high when the shaft speed is low. With this benefit, sensorless control strategy can be easily implemented in a wide speed range. In this paper, an improved sliding mode observer (SMO) is proposed to estimate the rotor position and the speed of the proposed machine. With the estimated shaft speeds, the maximum power point tracking (MPPT) control strategy is applied to maximize the wind power extraction. The machine design and the sensorless MPPT control strategy are verified by finite element analysis and experimental verification.
Impact of Partial and Comprehensive Smoke-Free Regulations on Indoor Air Quality in Bars
Authors: Kim Jeonghoon , Ban Hyunkyung , Hwang Yunhyung , Ha Kwonchul , Lee Kiyoung
Published: July 2016

In Korea, smoke-free regulations have been gradually implemented in bars based on venue size. Smoking bans were implemented in 2013 for bars ≥150 m2, in 2014 for bars ≥100 m2, and in 2015 for bars of all sizes. The purpose of this study was to determine indoor fine particle (PM2.5) concentrations in bars before and after implementation of the smoke-free policies based on venue size. Indoor PM2.5 concentrations were measured with real-time aerosol monitors at four time points: (1) pre-regulation (n = 75); (2) after implementing the ban in bars ≥150 m2 (n = 75); (3) after implementing the ban in bars ≥100 m2 (n = 107); and (4) when all bars were smoke-free (n = 79). Our results showed that the geometric mean of the indoor PM2.5 concentrations of all bars decreased from 98.4 μg/m3 pre-regulation to 79.5, 42.9, and 26.6 μg/m3 after the ban on smoking in bars ≥150 m2, ≥100 m2, and all bars, respectively. Indoor PM2.5 concentrations in bars of each size decreased only after the corresponding regulations were implemented. Although smoking was not observed in Seoul bars after smoking was banned in all bars, smoking was observed in 4 of 21 bars in Changwon. Our study concludes that the greatest decrease in PM2.5 concentrations in bars was observed after the regulation covering all bars was implemented. However, despite the comprehensive ban, smoking was observed in bars in Changwon. Strict compliance with the regulations is needed to improve indoor air quality further.
Hemoglobin Status and Externalizing Behavioral Problems in Children
Authors: Su Jianhua , Cui Naixue , Zhou Guoping , Ai Yuexian , Sun Guiju , Zhao Sophie , Liu Jianghong
Published: July 2016

Background: Still considered one of the most prevalent nutritional problems in the world, anemia has been shown in many studies to have deleterious effects on neurobehavioral development. While most research efforts have focused on investigating the effects of anemia on social and emotional development of infants by using a cross-sectional design, research is still needed to investigate whether early childhood anemia, beyond infantile years, is linked with behavioral problems. Objective: This study assessed whether (1) hemoglobin (Hb) levels in early childhood are associated with externalizing behavior; and (2) this relationship is confounded by social adversity. Methods: Hemoglobin levels were taken from children (N = 98) of the China Jintan Cohort Study at age 4 years, and externalizing behaviors (attention and aggression) were assessed with the Child Behavior Checklist (ASEBA-CBCL) at age 6 years (mean age 5.77 ± 0.39 years old). Results: Compared with other children in the sample, children with relatively lower Hb levels at age 4 had more behavioral problems in both attention and aggression at age 6, independent of social adversity. For boys, this association was significant for attention problems, which did not interact with social adversity. For girls, the association was significant for aggression, which interacted with social adversity. While girls on average exhibited higher social adversity than boys, the main effect of Hb was only significant in girls with low social adversity. Conclusions: These results indicate that there is an inverse association between hemoglobin levels and later behavioral problems. Findings of this study suggest that regular monitoring of children’s hemoglobin levels and appropriate intervention may help with early identification of behavioral problems.
Cytotoxicity Evaluation of Anatase and Rutile TiO2 Thin Films on CHO-K1 Cells in Vitro
Authors: Cervantes Blanca , López-Huerta Francisco , Vega Rosario , Hernández-Torres Julián , García-González Leandro , Salceda Emilio , Herrera-May Agustín , Soto Enrique
Published: July 2016

Cytotoxicity of titanium dioxide (TiO2) thin films on Chinese hamster ovary (CHO-K1) cells was evaluated after 24, 48 and 72 h of culture. The TiO2 thin films were deposited using direct current magnetron sputtering. These films were post-deposition annealed at different temperatures (300, 500 and 800 °C) toward the anatase to rutile phase transformation. The root-mean-square (RMS) surface roughness of TiO2 films went from 2.8 to 8.08 nm when the annealing temperature was increased from 300 to 800 °C. Field emission scanning electron microscopy (FESEM) results showed that the TiO2 films’ thickness values fell within the nanometer range (290–310 nm). Based on the results of the tetrazolium dye and trypan blue assays, we found that TiO2 thin films showed no cytotoxicity after the aforementioned culture times at which cell viability was greater than 98%. Independently of the annealing temperature of the TiO2 thin films, the number of CHO-K1 cells on the control substrate and on all TiO2 thin films was greater after 48 or 72 h than it was after 24 h; the highest cell survival rate was observed in TiO2 films annealed at 800 °C. These results indicate that TiO2 thin films do not affect mitochondrial function and proliferation of CHO-K1 cells, and back up the use of TiO2 thin films in biomedical science.
Application of Robust, Packaged Long-Period Fiber Grating for Strain Measurement
Authors: Ma Ke-Ping , Wu Chao-Wei , Hsieh Tso-Sheng , Hsieh Min-Yuan , Chiang Chia-Chin
Published: July 2016

This paper proposes an optical fiber strain sensor based on packaged long-period fiber gratings (PLPFG) which is fabricated by the micro-electromechanical systems (MEMS) process and packaged with poly-dimethylsiloxane (PDMS) polymer materials. The optical fiber sensor packaged with PDMS improves robustness effectively. The proposed PLPFG sensors have periods of 610, 650, 660 μm and fiber diameter of 48, 60, 72 μm, respectively. The resonance dip of the PLPFG grows when a strain loaded onto the sensor. The results show that the largest strain sensitivity of the PLPFG strain sensor was −0.0652 dB/με from 0–1200 με and the linearity (R2) was 0.9812. Accordingly, the proposed PLPFG sensor has good potential for high-sensitivity strain sensing applications.
Distributed Fiber-Optic Sensors for Vibration Detection
Authors: Liu Xin , Jin Baoquan , Bai Qing , Wang Yu , Wang Dong , Wang Yuncai
Published: July 2016

Distributed fiber-optic vibration sensors receive extensive investigation and play a significant role in the sensor panorama. Optical parameters such as light intensity, phase, polarization state, or light frequency will change when external vibration is applied on the sensing fiber. In this paper, various technologies of distributed fiber-optic vibration sensing are reviewed, from interferometric sensing technology, such as Sagnac, Mach–Zehnder, and Michelson, to backscattering-based sensing technology, such as phase-sensitive optical time domain reflectometer, polarization-optical time domain reflectometer, optical frequency domain reflectometer, as well as some combinations of interferometric and backscattering-based techniques. Their operation principles are presented and recent research efforts are also included. Finally, the applications of distributed fiber-optic vibration sensors are summarized, which mainly include structural health monitoring and perimeter security, etc. Overall, distributed fiber-optic vibration sensors possess the advantages of large-scale monitoring, good concealment, excellent flexibility, and immunity to electromagnetic interference, and thus show considerable potential for a variety of practical applications.
Fuzzy Adaptive Cubature Kalman Filter for Integrated Navigation Systems
Authors: Tseng Chien-Hao , Lin Sheng-Fuu , Jwo Dah-Jing
Published: July 2016

This paper presents a sensor fusion method based on the combination of cubature Kalman filter (CKF) and fuzzy logic adaptive system (FLAS) for the integrated navigation systems, such as the GPS/INS (Global Positioning System/inertial navigation system) integration. The third-degree spherical-radial cubature rule applied in the CKF has been employed to avoid the numerically instability in the system model. In processing navigation integration, the performance of nonlinear filter based estimation of the position and velocity states may severely degrade caused by modeling errors due to dynamics uncertainties of the vehicle. In order to resolve the shortcoming for selecting the process noise covariance through personal experience or numerical simulation, a scheme called the fuzzy adaptive cubature Kalman filter (FACKF) is presented by introducing the FLAS to adjust the weighting factor of the process noise covariance matrix. The FLAS is incorporated into the CKF framework as a mechanism for timely implementing the tuning of process noise covariance matrix based on the information of degree of divergence (DOD) parameter. The proposed FACKF algorithm shows promising accuracy improvement as compared to the extended Kalman filter (EKF), unscented Kalman filter (UKF), and CKF approaches.
Computing the Deflection of the Vertical for Improving Aerial Surveys: A Comparison between EGM2008 and ITALGEO05 Estimates
Authors: Barzaghi Riccardo , Carrion Daniela , Pepe Massimiliano , Prezioso Giuseppina
Published: July 2016

Recent studies on the influence of the anomalous gravity field in GNSS/INS applications have shown that neglecting the impact of the deflection of vertical in aerial surveys induces horizontal and vertical errors in the measurement of an object that is part of the observed scene; these errors can vary from a few tens of centimetres to over one meter. The works reported in the literature refer to vertical deflection values based on global geopotential model estimates. In this paper we compared this approach with the one based on local gravity data and collocation methods. In particular, denoted by ξ and η, the two mutually-perpendicular components of the deflection of the vertical vector (in the north and east directions, respectively), their values were computed by collocation in the framework of the Remove-Compute-Restore technique, applied to the gravity database used for estimating the ITALGEO05 geoid. Following this approach, these values have been computed at different altitudes that are relevant in aerial surveys. The (ξ, η) values were then also estimated using the high degree EGM2008 global geopotential model and compared with those obtained in the previous computation. The analysis of the differences between the two estimates has shown that the (ξ, η) global geopotential model estimate can be reliably used in aerial navigation applications that require the use of sensors connected to a GNSS/INS system only above a given height (e.g., 3000 m in this paper) that must be defined by simulations.
Design of a New Built-in UHF Multi-Frequency Antenna Sensor for Partial Discharge Detection in High-Voltage Switchgears
Authors: Zhang Xiaoxing , Cheng Zheng , Gui Yingang
Published: July 2016

In this study a new built-in ultrahigh frequency (UHF) antenna sensor was designed and applied in a high-voltage switchgear for partial discharge (PD) detection. The casing of the switchgear was initially used as the ground plane of the antenna sensor, which integrated the sensor into the high-voltage switchgear. The Koch snowflake patch was adopted as the radiation patch of the antenna to overcome the disadvantages of common microstrip antennas, and the feed position and the dielectric layer thickness were simulated in detail. Simulation results show that the antenna sensor possessed four resonant points with good impedance matching from 300 MHz to 1000 MHz, and it also presented good multi-frequency performance in the entire working frequency band. PD detection experiments were conducted in the high-voltage switchgear, and the fabricated antenna sensor was effectively built into the high-voltage switchgear. In order to reflect the advantages of the built-in antenna sensor, another external UHF antenna sensor was used as a comparison to simultaneously detect PD. Experimental results demonstrated that the built-in antenna sensor possessed high detection sensitivity and strong anti-interference capacity, which ensured the practicability of the design. In addition, it had more high-voltage switchgear PD detection advantages than the external sensor.
Recent Progress on Cellulose-Based Electro-Active Paper, Its Hybrid Nanocomposites and Applications
Authors: Khan Asif , Abas Zafar , Kim Heung , Kim Jaehwan
Published: July 2016

We report on the recent progress and development of research into cellulose-based electro-active paper for bending actuators, bioelectronics devices, and electromechanical transducers. The cellulose electro-active paper is characterized in terms of its biodegradability, chirality, ample chemically modifying capacity, light weight, actuation capability, and ability to form hybrid nanocomposites. The mechanical, electrical, and chemical characterizations of the cellulose-based electro-active paper and its hybrid composites such as blends or coatings with synthetic polymers, biopolymers, carbon nanotubes, chitosan, and metal oxides, are explained. In addition, the integration of cellulose electro-active paper is highlighted to form various functional devices including but not limited to bending actuators, flexible speaker, strain sensors, energy harvesting transducers, biosensors, chemical sensors and transistors for electronic applications. The frontiers in cellulose paper devices are reviewed together with the strategies and perspectives of cellulose electro-active paper and cellulose nanocomposite research and applications.
Autonomous Underwater Navigation and Optical Mapping in Unknown Natural Environments
Authors: Hernández Juan , Istenič Klemen , Gracias Nuno , Palomeras Narcís , Campos Ricard , Vidal Eduard , García Rafael , Carreras Marc
Published: July 2016

We present an approach for navigating in unknown environments while, simultaneously, gathering information for inspecting underwater structures using an autonomous underwater vehicle (AUV). To accomplish this, we first use our pipeline for mapping and planning collision-free paths online, which endows an AUV with the capability to autonomously acquire optical data in close proximity. With that information, we then propose a reconstruction pipeline to create a photo-realistic textured 3D model of the inspected area. These 3D models are also of particular interest to other fields of study in marine sciences, since they can serve as base maps for environmental monitoring, thus allowing change detection of biological communities and their environment over time. Finally, we evaluate our approach using the Sparus II, a torpedo-shaped AUV, conducting inspection missions in a challenging, real-world and natural scenario.
Finding Factors that Influence Carsharing Usage: Case Study in Seoul
Authors: Kang Junhee , Hwang Keeyeon , Park Sungjin
Published: July 2016

The goal of this research is to investigate the factors that affect carsharing demand. As a proxy for carsharing demand, the number of (booking) transactions made by carsharing users is counted based on the data from one of the two major carsharing operators in Seoul, Korea. In order to identify the factors influencing station-based carsharing usage, multiple linear regression modeling was performed with the number of carsharing transactions as a dependent variable and with the three groups of independent variables: Built environment, demographic, and transportation variables. Instead of using the locations of the pods, this study uses the residential locations of carsharing users who made transactions, and the final result analyzing 420 districts shows that six variables significantly influence carsharing usage. Carsharing demand is high in an area where a higher proportion of building floor area is used for business, and which has a higher proportion of young residents in their 20s and 30s. It can also be predicted that the area with more registered cars and less subway entrances will show higher carsharing demand. The analysis result also suggests that providing additional carsharing pods, especially pods that utilize city owned public parking facilities, will help promote carsharing usage. This research establishes a basis for future research efforts to forecast carsharing demand and to identify areas with high potential, especially in major Asian cities.
Small Boreal Lake Ecosystem Evolution under the Influence of Natural and Anthropogenic Factors: Results of Multidisciplinary Long-Term Study
Authors: Shirokova Liudmila , Vorobieva Taissia , Zabelina Svetlana , Klimov Sergey , Moreva Olga , Chupakov Artem , Makhnovich Natalia , Gogolitsyn Vladimir , Sobko Elena , Shorina Natalia , Kokryatskaya Natalia , Ershova Anna , Pokrovsky Oleg
Published: July 2016

Small aquatic ecosystems of the boreal zone are known to be most sensitive indicators of on-going environmental change as well as local anthropogenic pressure, while being highly vulnerable to external impacts. Compared to rather detailed knowledge of the evolution of large and small lakes in Scandinavia and Canada, and large lakes in Eurasia, highly abundant small boreal lakes of northwest Russia have received very little attention, although they may become important centers of attraction of growing rural population in the near future. Here we present the results of a multidisciplinary, multi-annual study of a small boreal humic lake of NW Russia. A shallow (3 m) and a deep (16 m) site of this lake were regularly sampled for a range of chemical and biological parameters. Average multi-daily, summer-time values of the epilimnion (upper oxygenated) layer of the lake provided indications of possible trends in temperature, nutrients, and bacterio-plankton concentration that revealed the local pollution impact in the shallow zone and overall environmental trend in the deep sampling point of the lake. Organic phosphorus, nitrate, and lead were found to be most efficient tracers of local anthropogenic pollution, especially visible in the surface layer of the shallow site of the lake. Cycling of trace elements between the epilimnion and hypolimnion is tightly linked to dissolved organic matter speciation and size fractionation due to the dominance of organic and organo-ferric colloids. The capacity of lake self-purification depends on the ratio of primary productivity to mineralization of organic matter. This ratio remained >1 both during winter and summer periods, which suggests a high potential of lake recovery from the input of allochthonous dissolved organic matter and local anthropogenic pollution.
Photocurrent generation in carbon nanotube/cubic-phase HfO2 nanoparticle hybrid nanocomposites
Authors: Rauwel Protima , Galeckas Augustinas , Salumaa Martin , Ducroquet Frédérique , Rauwel Erwan
Published: July 2016

A hybrid material consisting of nonfunctionalized multiwall carbon nanotubes (MWCNTs) and cubic-phase HfO2 nanoparticles (NPs) with an average diameter of 2.6 nm has been synthesized. Free standing HfO2 NPs present unusual optical properties and a strong photoluminescence emission in the visible region, originating from surface defects. Transmission electron microscopy studies show that these NPs decorate the MWCNTs on topological defect sites. The electronic structure of the C K-edge in the nanocomposites was probed by electron energy loss spectroscopy, highlighting the key role of the MWCNT growth defects in anchoring HfO2 NPs. A combined optical emission and absorption spectroscopy approach illustrated that, in contrast to HfO2 NPs, the metallic MWCNTs do not emit light but instead expose their discrete electronic structure in the absorption spectra. The hybrid material manifests characteristic absorption features with a gradual merger of the MWCNT π-plasmon resonance band with the intrinsic defect band and fundamental edge of HfO2. The photoluminescence of the nanocomposites indicates features attributed to combined effects of charge desaturation of HfO2 surface states and charge transfer to the MWCNTs with an overall reduction of radiative recombination. Finally, photocurrent generation under UV–vis illumination suggests that a HfO2 NP/MWCNT hybrid system can be used as a flexible nanodevice for light harvesting applications.
La rupture de 1955 dans la formation du régime européen de migrations
Authors: Comte Emmanuel
Published: July 2016

Cet article met en lumière et explique le tournant de 1955 dans l’évolution des rapports migratoires entre les États de l’Europe d’après-guerre. L’étude remet en cause les conclusions des travaux précédents, en identifiant cette rupture et les forces sous-jacentes. Ce travail s’appuie sur les documents des organisations internationales associées à ces épisodes : l’Organisation européenne de coopération économique, le Conseil de l’Europe, la Communauté européenne du charbon et de l’acier et la Communauté économique européenne. Il se fonde également sur les archives des gouvernements français et surtout ouest-allemand. Alors que les travaux précédents avaient mis en avant le rôle de la stratégie italienne, cet article décrit et place au cœur de ce changement la stratégie du gouvernement allemand, liée au contexte de la Guerre froide.
Inflammation-related pro-apoptotic activity of exopolysaccharides isolated from Lactococcus lactis subsp. lactis
Authors: Wu Z. , Wang G. , Pan D. , Guo Y. , Zeng X. , Sun Y. , Cao J.
Published: July 2016

Exopolysaccharides (EPS) have attracted attention recently for possible use in suppressing early stage breast cancer. In this study, a mannan EPS produced by Lactococcus lactis subsp. lactis was found to affect the production of inflammatory cytokines. EPS (300 μg/ml) can significantly enhance tumour necrosis factor alpha and inducible NO synthase release in MCF-7 cells compared to control cells in a concentration-dependent manner. Also the intracellular calcium level was found to increase with the concentration of EPS. After EPS-treatment, a significant reduction in mitochondrial potential was observed, as was nuclear condensation and cell shrinkage. These results may be helpful in further understanding the anti-tumour properties of lactic acid bacteria.
Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease
Authors: McIver Zachariah A. , Grayson Jason M. , Coe Benjamin N. , Hill Jacqueline E. , Schamerhorn Gregory A. , Ohulchanskyy Tymish Y. , Linder Michelle K. , Davies Kellie S. , Weiner Roy S. , Detty Michael R.
Published: July 2016

T lymphocytes play a central role in many human immunologic disorders, including autoimmune and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient’s tissues from donor allogeneic T cells. Selectively depleting GVHD-causing cells prior to transplant may prevent GVHD. In this study, we evaluated 24 chalcogenorhodamine photosensitizers for their ability to selectively deplete reactive T lymphocytes and identified the photosensitizer 2-Se-Cl, which accumulates in stimulated T cells in proportion to oxidative phosphorylation. The photosensitizer is also a potent stimulator of P-glycoprotein (P-gp). Enhanced P-gp activity promotes the efficient removal of photosensitizer not sequestered in mitochondria and protects resting lymphocytes that are essential for antipathogen and antitumor responses. To evaluate the selective depletion of alloimmune responses, donor C57BL/6 splenocytes were cocultured for 5 d with irradiated BALB/c splenocytes and then photodepleted (PD). PD-treated splenocytes were infused into lethally irradiated BALB/c (same-party) or C3H/HeJ (third-party) mice. Same-party mice that received PD-treated splenocytes at the time of transplant lived 100 d without evidence of GVHD. In contrast, all mice that received untreated primed splenocytes and third-party mice that received PD-treated splenocytes died of lethal GVHD. To evaluate the preservation of antiviral immune responses, acute lymphocytic choriomeningitis virus infection was used. After photodepletion, expansion of Ag-specific naive CD8+ T cells and viral clearance remained fully intact. The high selectivity of this novel photosensitizer may have broad applications and provide alternative treatment options for patients with T lymphocyte–mediated diseases.
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation
Authors: Zhou Weisong , Zhang Jian , Goleniewska Kasia , Dulek Daniel E. , Toki Shinji , Newcomb Dawn C. , Cephus Jacqueline Y. , Collins Robert D. , Wu Pingsheng , Boothby Mark R. , Peebles R. Stokes
Published: July 2016

Allergic airway diseases are immune disorders associated with heightened type 2 immune responses and IL-5 and IL-13 production at the site of inflammation. We have previously reported that cyclooxygenase (COX) inhibition by indomethacin augmented allergic airway inflammation in a STAT6-independent manner. However, the key COX product(s) responsible for restraining indomethacin-mediated STAT6-independent allergic inflammation is unknown. In this study, using the mouse model of OVA-induced allergic airway inflammation, we identified that PGI2 receptor (IP) signaling was critical for indomethacin-induced, STAT6-independent proallergic effects. We demonstrated that IP deficiency increased inflammatory cell infiltration, eosinophilia, and IL-5 and IL-13 expression in the lung in a STAT6-independent manner. The augmented STAT6-independent allergic inflammation correlated with enhanced primary immune responses to allergic sensitization and elevated production of multiple inflammatory chemokines (CCL11, CCL17, CCL22, and CXCL12) in the lung after allergen challenge. We also showed that the PGI2 analogue cicaprost inhibited CD4 T cell proliferation and IL-5 and IL-13 expression in vitro, and IP deficiency diminished the stimulatory effect of indomethacin on STAT6-independent IL-5 and IL-13 responses in vivo. The inhibitory effects of PGI2 and the IP signaling pathway on CD4 T cell activation, inflammatory chemokine production, and allergic sensitization and airway inflammation suggest that PGI2 and its analogue iloprost, both Food and Drug Administration–approved drugs, may be useful in treating allergic diseases and asthma. In addition, inhibiting PGI2 signaling by drugs that either block PGI2 production or restrain IP signaling may augment STAT6-independent pathways of allergic inflammation.
Plasmacytoid Dendritic Cells Die by the CD8 T Cell–Dependent Perforin Pathway during Acute Nonviral Inflammation
Authors: Mossu Adrien , Daoui Anna , Bonnefoy Francis , Aubergeon Lucie , Saas Philippe , Perruche Sylvain
Published: July 2016

Regulation of the inflammatory response involves the control of dendritic cell survival. To our knowledge, nothing is known about the survival of plasmacytoid dendritic cells (pDC) in such situation. pDC are specialized in type I IFN (IFN-I) secretion to control viral infections, and IFN-I also negatively regulate pDC survival during the course of viral infections. In this study, we asked about pDC behavior in the setting of virus-free inflammation. We report that pDC survival was profoundly reduced during different nonviral inflammatory situations in the mouse, through a mechanism independent of IFN-I and TLR signaling. Indeed, we demonstrated that during inflammation, CD8+ T cells induced pDC apoptosis through the perforin pathway. The data suggest, therefore, that pDC have to be turned down during ongoing acute inflammation to not initiate autoimmunity. Manipulating CD8+ T cell response may therefore represent a new therapeutic opportunity for the treatment of pDC-associated autoimmune diseases, such as lupus or psoriasis.