bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacto del alcohol y la dieta en la calidad de vida en la educación superior. Un modelo de ecuaciones estructurales
Authors: Ubago-Jiménez José Luis , Zurita-Ortega Félix , Melguizo-Ibáñez Eduardo , Alonso-Vargas José Manuel
Published: February 2025

El consumo de alcohol de la juventud durante el periodo universitario ha aumentado exponencialmente en los últimos años. Además, el cambio de estilo de vida se asocia al abandono de la dieta mediterránea, aumentando el riesgo de sufrir algún tipo de lesión y afectando a su calidad de vida. El estudio se realizó con una muestra de 1057 estudiantes universitarios españoles, el 12,1% (n = 127) de mujeres y el 87,9% (n = 930) de hombres. Se utilizó el cuestionario SF-36 para medir la calidad de vida relacionada con la salud; el test MEDAS para comprobar la adherencia a la dieta mediterránea; y el test AUDIT para medir el consumo de alcohol. Los resultados muestran una relación inversa entre la lesión y la calidad de vida (β= -0,020) y la adherencia a la dieta mediterránea (β= -0,042) entre los estudiantes que han sufrido algún tipo de lesión. Por otro lado, se observa una relación positiva con el consumo de alcohol (β= -0,046). La principal conclusión es que un menor consumo de alcohol y una mayor adherencia a la dieta mediterránea se asociaron con una mejor calidad de vida y un menor riesgo de lesiones en los estudiantes universitarios del sur de España.
Factores asociados al abuso de videojuegos en mujeres adolescentes
Authors: Bernaldo-de-Quirós Aragón Mónica , Herrera Baños Lucía , Sánchez-Iglesias Iván , Fernández-Arias Ignacio , Estupiñá Puig Francisco , Labrador Méndez Marta , Vallejo-Achón Marina , Labrador Francisco J.
Published: February 2025

Jugar a videojuegos puede convertirse en una conducta problemática. Los factores asociados a esta transición han sido ampliamente estudiados en varones, mientras que entre las mujeres es un campo aún no suficientemente abordado. El objetivo de este trabajo fue identificar qué factores de riesgo pueden estar asociados al uso problemático de videojuegos en mujeres adolescentes. En concreto, analizar el potencial predictivo de los hábitos de juego, la sintomatología psicopatológica y las cogniciones desadaptativas relacionadas con los videojuegos. Mediante muestreo aleatorio estratificado de los centros educativos de la Comunidad de Madrid se obtuvo una muestra de 536 mujeres (12-17 años) (M= 13,91; DT= 1,57), a las que se aplicó el Gamertest, un sistema experto online para evaluar el uso problemático de videojuegos. Un 2,8% de las adolescentes presentaban un uso problemático de videojuegos, y tan sólo un 0,7% un Trastorno por Juego en Internet. Las principales variables predictoras identificadas fueron: las cogniciones relacionadas con compulsión y preocupación, el promedio de días de juego a la semana y la sintomatología ansiosa. Los resultados obtenidos se suman a los escasos estudios realizados en mujeres y ponen de manifiesto la necesidad de prestar atención, especialmente, a las cogniciones desadaptativas relacionadas con los videojuegos en la prevención y tratamiento de estos problemas.
Sobre la prevención del uso de Cigarrillos Electrónicos en adolescentes
Authors: Carballo José Luis , Pascual Pastor Francisco
Published: February 2025

Editorial del volumen 36-4
Feathered Predators: The Role of Plumage in the Hunting Tactics of Velociraptor
Authors: Hu Tyler
Published: February 2025

This literature review investigates the role of plumage in the hunting tactics of Velociraptor, integrating anatomical analysis and biomechanical modeling. Velociraptor, a swift and agile theropod from the Late Cretaceous, exhibited advanced intelligence and sensory capabilities that contributed to its effective predatory strategies. Recent discoveries have confirmed that Velociraptor was covered in feathers, with quill knobs indicating well-developed plumage. This review explores the potential functions of feathers beyond flight, focusing on their impact on hunting behavior. Evidence suggests that Velociraptor’s plumage likely facilitated camouflage and enhanced aerodynamic control, improving its stealth and maneuverability during high-speed chases. Additionally, feathers might have contributed to stability during incline running, further supporting its adaptability in diverse environments. Velociraptor’s hunting strategies, characterized by agility and precision, were complemented by its feathered anatomy, which may have also played a role in pack hunting and social interactions. Overall, the integration of plumage with Velociraptor’s anatomical features and behavioral adaptations underscores its efficiency as a predator, demonstrating how feathers may have been a critical factor in its successful hunting tactics.
The Dynamic Regenerative Scaffold Stenting & Shielding Hernia System for Dissection-Free, Atraumatic Hernioplasty. Results of an Experimental Animal Study
Authors: Amato Giuseppe , Romano Giorgio , Roberto Puleio , Giuseppe Di Buono , Cicero Luca , Cassata Giovanni , Romano Giorgio , Neto Claudia , Rà William , Rodolico Vito , Agrusa Antonino
Published: February 2025

Conventional hernia repair using static flat meshes is often associated with complications casused by extensive dissection, implant fixation, and poor biological response. The Stenting & Shielding (S&S) Hernia System offers a novel solution designed for dissection-free, fixation-free hernia repair. The S&S Hernia System has been evaluated in a porcine model, focusing on procedural simplicity, device retention and regenerative properties. The experimental study involved 10 pigs, each implanted with two S&S devices. Follow-up assessments included ultrasound, laparoscopic examinations, and histological analyses over a period ranging from 4 weeks to 8 months post-implantation. The S&S Hernia System, made from medical-grade polypropylene-based thermoplastic elastomer (TPE), features a rayed 3D scaffold and an oval shield connected by a mast. Delivered and positioned intraabdominally without dissection, the device transforms into a self-retaining scaffold to obliterate the hernia defect. Primary outcomes included ease of delivery, visceral adhesion formation, and device retention, ensuring no dislocation. Secondary outcomes evaluated histological evidence of tissue regeneration, including the development of connective tissue, muscles, vessels, and nerves within the scaffold. Immunohistochemistry was used to detect tissue growth factors promoting regeneration of the abdominal wall's typical components. All 20 implanted devices remained securely in place without dislocation. Transient adhesion bands were observed in two shields at 1 month but resolved by 3 months. No visceral adhesions were detected at the time of animal sacrifice. Histological analyses demonstrated tissue regeneration within the scaffold, while immunohistochemistry confirmed the presence of growth factors supporting regeneration. Overall, the S&S Hernia System showed promising results in a porcine model, with no dislocation and evident regenerative potential. Its rapid, dissection-free delivery and compliance with abdominal wall dynamics simplify the procedure while minimizing adhesions. These findings warrant further clinical investigation to validate its application in human patients.
Evaluation of the Energy Quality of a 2 MWp Photovoltaic Power Plant Integrated into the Distribution Network: Revision of the EN50160 Standard on Total Harmonic Distortion and Voltage Variations
Authors: BOUZBIBA Azeddine , TALEB YASSINE , ABBOU AHMED
Published: February 2025

With the increasing integration of renewable energy sources into the distribution network and the growing complexity of modern power grids, electricity quality has become a major concern. This paper analyzes the performance of a 2 MWp photovoltaic power plant connected to a 22 kV distribution grid, focusing on Total Harmonic Distortion (THD) and voltage unbalances, including homopolar and inverse components.
Measurements taken during critical periods, particularly at sunrise and sunset, highlight the need to review energy quality parameters over time intervals shorter than ten minutes to better detect and understand significant deviations, especially in grids with high renewable energy integration.
This study highlights the shortcomings of existing standards and proposes revisions to better ad-dress the challenges posed by renewable energy integration. The recommendations aim to improve electricity quality assessment and ensure optimal compatibility with contemporary and future technologies.
The Role of the Sirtuin Family Histone Deacetylases in Acute Myeloid Leukemia – a Promising Road Ahead
Authors: Strzałka Piotr , Krawiec Kinga , Wiśnik Aneta , Jarych Dariusz , Czemerska Magdalena , Zawlik Izabela , Pluta Agnieszka , Wierzbowska Agnieszka
Published: February 2025

Acute myeloid leukemia (AML) corresponds to a heterogeneous group of clonal hematopoietic diseases, which are characterized by uncontrolled proliferation of malignant transformed myeloid precursors and their inability to differentiate into mature blood cells. The prognosis of AML depends on many variables, including the genetic features of the disease. Treatment outcomes, despite the introduction of new targeted therapies, are still unsatisfactory. Recently, there have been an increasing number of reports on enzymatic proteins of the sirtuin family and their potential importance in cancer in general. Sirtuins are a group of 7 (SIRT1-7) NAD+-dependent histone deacetylases with pleiotropic effects on metabolism, aging processes, and cell survival. They are not only responsible for post-translational modification of histones but also play various biochemical functions and interact with other proteins regulating cell survival, such as p53. Thus, their role in key mechanisms of tumorigenesis makes them a worthwhile topic in AML. Different sirtuins have been shown to act oppositely depending on the biological context, the mechanism of which requires further exploration. This review provides a comprehensive description of the significance and role of sirtuins in AML in the light of the current state of knowledge. It focuses in particular on molecular mechanisms regulated by sirtuins and signaling pathways involved in leukemogenesis, as well as clinical aspects and potential therapeutic targets in AML.
Ruptured Intracranial Dermoid Cyst with Fat Dissemination: A Clinical Case Mimicking an Epidermoid Cyst and Review of the Literature
Authors: Verzemnieks Kalvis , Tumelkans Roberts , Strautmane Sintija , Kalejs Verners Roberts , Dolgopolova Julija , Valeinis Egils , Tone Tatjana , Balodis Arturs
Published: February 2025

Background. Intracranial dermoid cysts (IDC) are rare benign congenital intracranial lesions. In the case of IDC rupture, these lesions may manifest clinically. Cysts may be visualized on non-enhanced computed tomography (NECT) and magnetic resonance imaging (MRI), facilitating discussions between clinicians and radiologists to determine cyst content and potential dissemination in cases of rupture. This case report describes an IDC rupture presenting as fat-containing lesions in the subarachnoid space and ventricular system, resembling a subarachnoid hemorrhage on MRI. Case report. A thirty-two-year-old Caucasian male patient was admitted to the hospital due to recurrent headache and visual impairment that began at the age of thirty-one. MRI revealed a lesion radiologically consistent with a ruptured dermoid or epidermoid cyst in the anterior fossa with a mass effect on the optic nerve intracranial segments, the chiasma opticum, and proximal optic tracts. The patient underwent a successful neurosurgical resection of the lesion, and histopathological analysis confirmed the diagnosis of a dermoid cyst. The postoperative period was uneventful. MRI follow-up revealed residual tissue of the IDC without any volume increase. Multiple punctate fat-containing lesions were noted, similar to previous MRI. The patient reported no complaints at discharge. Follow-up MRI imaging demonstrated no recurrence or progression of the dermoid cyst at 4 months, 1 year, and 2 years. Conclusion. IDC rupture is a rare event that may present clinically and appear as a blooming artifact on MRI, mimicking subarachnoid hemorrhage. Fat-containing lesions in the subarachnoid space and ventricular system can demonstrate findings indicative of an IDC rupture. MRI diffusion-weighted imaging (DWI) and decreased apparent diffusion coefficient (ADC) values may mimic an epidermoid cyst, a phenomenon rarely described in the literature, further complicating the diagnostic process.
Trastuzumab Resistance, a Potential Roadblock to the Most Successful Therapy for Breast Cancer – a Review of Underlying Mechanisms with Relevant Patents and Clinical Trials to Overcome the Resistance
Authors: Hasan Gul , Singh Sandhya , Gurav Pravin , Penumaka Sudha Madhavi , Kumar Saurabh , Kumar Sudheer , Mandal Debabrata
Published: February 2025

In the 1980s, the discovery of a 185 KDa transmembrane human receptor protein which is now known as human epidermal growth factor receptor 2 (HER2), paved the way for the development of the most successful and 1st humanized monoclonal antibody, Trastuzumab. The antibody received FDA and EU approval in 1998 and 2000, respectively for the treatment of patients with HER2+ breast cancer (BC). The high affinity of Trastuzumab binding with HER2 having a Kd value of < 1 nM is due to the dual action of two antibody domains. Here, the Fab domain provides selective binding with the HER2 receptor whereas the Fc domain binds with the Fc receptor in natural killer cells and leukocytes to kill the tumour cells by antibody-directed cellular cytotoxicity (ADCC). Trastuzumab is widely used for the treatment of BC where it blocks the over-expressed HER2 receptor-mediated dimerization and consequent intracellular signaling that leads to cancerous growth. The phosphatidylinositol 3′-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin pathway (mTOR), cross-talk with estrogen receptors, over-expression of Mucin 1 (MUC1) protein, and involvement of tyrosine kinase receptors like insulin-like growth factor I receptor are key pathways involved in trastuzumab resistance (TR). In this review, we have provided a molecular view of how this resistance appears, and what are the possible remedies using BC stem cell (BCSC)-based therapy, PI3K pathway inhibitors, MUC1-directed therapy, etc. We have also elaborated on the claims from different patents and data from clinical trials where overcoming the TR is one of the primary focuses of those studies.
Geospatial Analysis of Regional Disparities in Non-Grain Cultivation: Spatiotemporal Patterns and Driving Mechanisms in Jiangsu, China
Authors: Chen Yingxi , Xu Yan , Ye Nannan
Published: February 2025

Balancing regional disparities in non-grainization at the prefecture level is vital for stable grain production and sustainable urbanization. This study employs geospatial analysis to examine the spatiotemporal patterns and driver factors of non-grainization in Jiangsu Province from 2001 to 2020. By integrating geospatial data from 77 county-level units and employing spatial autocorrelation analysis, multiple linear regression, and Mixed Geographically Weighted Regression (MGWR), this study reveals the spatial heterogeneity and key driving factors of non-grainization. The results indicate that despite cyclical fluctuations in the provincial non-grainization rate, significant regional differences persist. High–high clusters are evident in economically developed southern and coastal areas, while low–low clusters are observed in less developed northern regions, indicating strong spatial dependence. Furthermore, the analysis reveals that rural residents' per capita disposable income and total agricultural output contribute to the process of non-grainization, emphasizing the impact of economic development on land use decisions. These findings highlight the importance of geoinformation tools in managing regional disparities. Integrating spatial and socioeconomic analysis offers practical insights for policymakers to develop targeted strategies that balance food security with agricultural diversification. This study provides valuable insights for policymakers seeking to optimize land-use planning in rapidly urbanizing agricultural regions.
An Alternative and Simple View of the Universe
Authors: Li Qingsong
Published: February 2025

Over the past century, physics has evolved in a way that deviates from intuition and is extremely difficult for ordinary people to understand. Modern physics is primarily based on special and general relativity, as well as quantum mechanics. These two theories introduce several well-known counterintuitive concepts, such as the relativity of simultaneity, curved space-time, the probabilistic nature of particles, quantum entanglement, and the Big Bang. While these theories have practical applications, they are not easily comprehensible to the general public. In this paper, we propose an alternative and simplified perspective on the universe, hoping that readers will find it easier to understand and enjoy.
Impact of Schistosoma mansoni Infection on the Gut Microbiome and Hepatitis B Vaccine Immune Response in Fishing Communities of Lake Victoria, Uganda
Authors: Wang Yan , Waters Ariana Kerngel , Basalirwa Geofrey , Ssetaala Ali , Mpendo Juliet , Namuniina Annemarie , Keneema Emily , Kiiza David , Lugemwa Jacqueline , Mayanja Yunia , Okech Brenda , Muyingo Sylvia Kiwuwa
Published: February 2025

Objective: Schistosoma mansoni (S. mansoni) infection is endemic in fishing communities. We investigated its potential impact on Hepatitis B (Hep B) vaccine responses and its role in mediating the association between the gut microbiome and the long-term effectiveness of the vaccine response. Methods: Participants were tested for S. mansoni infections at baseline and received the Hep B vaccine at baseline, month 1, and month 6. Those with infections were treated. Stool samples were collected at baseline and analyzed using 16S rRNA sequencing. The Wilcoxon rank-sum test was used to compare alpha diversity between groups. A linear regression model was applied to estimate the association between one-year Hep B vaccine responses and baseline gut microbiome by infection status, adjusting for age and sex. Results: A total of 107 participants were included (44 from the fishing community and 63 from the Kampala community). There was no significant difference in microbiome composition by location or infection status at baseline or exit. In the linear regression analysis, S. mansoni infection (β = 1.24, p = 0.025) and higher alpha diversity (β = 0.001, p = 0.07) were associated with higher Hep B vaccine responses, while older age was associated with a lower Hep B vaccine response (β = -0.06, p = 0.0013). Conclusions: S. mansoni infection status before vaccination may modify the association between the gut microbiome and Hep B vaccine response. Potential interventions could focus on infection control as well as improving microbiome richness before implementing vaccine programs in fishing communities.
A New Proof Of Eckart-Young-Mirsky Theorem
Authors: Wang Haoyuan
Published: February 2025

It is apologize to upload this incomplete draft since the time limitation, yet in this paper, we are going to give a new proof of the Eckart-Young-Mirsky Theorem which is crucial in machine learning, image and date processing etc.
Uav Audio Signal Detection Method Based on Gru and Attention Mechanism
Authors: Xu Lan , Luo Zhongqiang
Published: February 2025

The rapid development of drone technology has resulted in its ever-expanding applications in the military, commercial, and civilian domains. Nevertheless, the concomitant safety and privacy issues have become increasingly conspicuous, giving rise to an urgent demand for effective monitoring and management of drone activities. Consequently, anti-drone detection and recognition technology has gradually emerged as a research focus. Deep learning provides innovative solutions for drone detection by virtue of its advantages in complex data feature extraction and intelligent signal analysis. In this paper, a UAV audio signal detection method based on GRU neural network and attention mechanism is proposed to solve the limitations of traditional convolutional neural network (CNN) in dealing with background noise and interference signals. In this study, one-dimensional waveform data is converted into a two-dimensional feature space through spectrogram feature extraction of audio signals, so as to capture the global temporal characteristics and dynamic features of UAV audio signals. In the model design, a lightweight two-layer GRU neural network is adopted, which combines the update gate and reset gate mechanisms to effectively capture the short-term and long-term dependencies in the audio signal, avoid the gradient vanishing problem, and improve the computational efficiency and generalization capability. In addition, to further enhance the ability of the model to focus on long time series and complex background signals, an attention mechanism is introduced so that the model can dynamically focus on the information of key time steps, thus improving the robustness of complex signal processing. In order to verify the effectiveness of the proposed method, we conducted experiments on publicly available UAV audio datasets, and the results show that the method proposed in this paper exhibits high detection accuracy and robustness in dealing with the task of UAV audio detection in complex environments, which provides reliable technical support for the development of UAV detection technology.
On a Higgs-Mediated Relation Between Elementary Particles and Spacetime and Its Physical Consequences
Authors: Licata Ignazio , Chiatti Leonardo
Published: February 2025

A specific structure of Standard Model (SM) particles is proposed and investigated. According to this proposal a de Sitter space is tangent to ordinary spacetime in each point-event; the value of the gravitational constant within such a space does not necessarily have to coincide with that relating to ordinary spacetime, and it is chosen as a function of the Higgs vacuum. The curvature of this space is sized by the Higgs boson mass. This space is a solution of the corresponding Einstein gravitational equations, if the internal density is suitably chosen and the internal pressure is assumed to be negative. An elementary fermion of the SM can then be described by a field of similar spaces whose internal gravitational constant is redefined in such a way as to assure the proportionality between mass and coupling constant to the Higgs field as required by the SM. The de Sitter radius then turns out to be, at the same time, the classical radius of the fermion and the "gravitational" radius in the sense of the internal gravitational constant. The quantum version of the fermion is obtained by passing from the Einstein gravitational equations to the Wheeler - de Witt (WdW) equation. There are free solutions both harmonic and exponential. The former correspond to de Broglie plane waves and can be superposed in order to provide the usual solutions of the relativistic wave equations. The latter describe quantum jumps in full compliance with Einstein locality. The reduction of the projection postulate to a dynamical consequence on the level of elementary particles implies the production of true decoherence induced by microscopic interactions, without any tracing out of environmental degrees of freedom, and the calculation of the decoherence time is illustrated in a simple case. The interaction of SM gauge bosons with elementary fermions (with and without production of quantum jumps) is modeled according to the same scheme. A possible interpretation of the fine structure constant and a formula for calculating the coefficients of the CKM, PMNS matrices are derived in this context. Other consequences of the model of potential theoretical interest are reviewed.
On Finite Exceptional Orthogonal Polynomial Sequences Composed of Rational Darboux Transforms of Romanovski-Jacobi Polynomials
Authors: Natanson Gregory
Published: February 2025

The paper presents the united analysis of the finite exceptional orthogonal polynomial (EOP) sequences composed of rational Darboux transforms of Romanovski-Jacobi polynomials. It is shown that there are four distinguished exceptional differential polynomial systems (X-Jacobi DPSs) of series J1, J2, J3, and W. The first three X-DPSs formed by pseudo-Wronskians of two Jacobi polynomials contain both exceptional orthogonal polynomial systems (X-Jacobi OPSs) on the interval (-1,+1) and the finite EOP sequences on the positive interval (1,Inf). On the contrary, the X-DPS of series W formed by Wronskians of two Jacobi polynomials contains only (infinitely many) finite EOP sequences on the interval (1,Inf). In addition, the paper rigorously examines the three isospectral families of the associated Liouville potentials (rationally extended hyperbolic Pöschl-Teller potentials of types a, b, and a’) exactly quantized by the EOPs in question.
Biobased Filler Materials in Polymeric Composites: A Comprehensive Review of Epoxy and Polyurethane Systems
Authors: Onwubu Stanley Chibuzor , Naidoo Deneshree , Obiechefu Zodidi , Mokhothu Thabang Hendrica
Published: February 2025

Polymeric composites, particularly epoxy and polyurethane systems, have gained significant attention due to their excellent mechanical, thermal, and chemical properties. However, the environmental concerns associated with petroleum-based polymers have driven research towards biobased alternatives. This review explores the integration of biobased filler materials derived from agricultural and marine waste into epoxy and polyurethane matrices to enhance their performance while promoting sustainability. The empirical review of epoxy and polyurethane resins reinforced with natural fillers highlights the significant role of bio-based additives in enhancing mechanical properties while promoting sustainability. Findings from reviewed studies demonstrate that natural fillers such as jute, sisal, lignin, and rice husk fish scales improve tensile strength, flexural strength, and wear resistance of polymer composites. However, excessive filler content can lead to agglomeration, reducing mechanical integrity. Optimal filler content varies depending on polymer type, with moderate concentrations yielding the best mechanical performance. Additionally, chemical modifications, such as silane treatment and alkalization, enhance filler-polymer adhesion, further improving material properties. Despite their advantages, challenges such as moisture sensitivity and long-term durability require further investigation.
Sustainable Strategies to Reduce Logistics Costs Based on Cross-Docking – the Case of Eastern and Central Europe as an Emerging Region
Authors: Toth Zsolt , Goga Alexandru-Silviu , Boșcoianu Mircea
Published: February 2025

The management of cross-dock (C-D) platforms in Eastern and Central Europe (ECE) faces in-creasing complexity amid persistent uncertainty and inflationary pressures. While artificial intelligence (AI) offers opportunities for innovation, capital costs remain significant, creating challenges for sustainable logistics operations. This study investigates strategies for reducing logistics costs through C-D while maintaining social responsibility standards in emerging markets. Our methodology employs a mixed-method approach incorporating pre-analysis of 33 recent bibliographical sources and quantitative modeling of C-D scenarios. We integrate environmental, social, corporate governance (ESG) and AI analysis using balanced scorecard (BSC) criteria, along-side activity-based costing (ABC) and corporate social responsibility (CSR) implementation for resource management. The study examines three strategic C-D locations: Bratislava, Prague, and Budapest. Results demonstrate that optimized C-D operations achieve cost reductions of 10.61% for ECE inbound logistics and 3.84% for Western European (WE) outbound logistics when utilizing the Budapest location. ABC analysis reveals labor (35-40%), equipment utilization (25-30%), and facility operations (20-25%) as primary cost drivers. The findings confirm that successful C-D in emerging markets require balanced integration of operational efficiency and sustainability practices. This research provides empirical evidence for logistics managers and policymakers, offering a comprehensive framework for implementing sustainable C-D strategies in developing regions.
Association of Nutritional Status and Cognitive Development in Preschoolers: A Public Health and Educational Cross-Sectional Study
Authors: Sharma Prakash , Budhathoki Chitra , Devkota Bhimsen , Syrou Niki , Valamontes Antonios , Adamopoulos Ioannis
Published: February 2025

Nutritional deficiencies negatively impact cognitive development in preschoolers, affecting brain growth and causing behavioral and educational consequences. This study evaluates the relationship between nutritional status and cognitive development, highlighting the public health and educational implications of cognitive developmental delays and the increasing malnutrition among children. This study aimed to explore the factors influencing cognitive development in preschoolers (ages 3-5) in Rupandehi District, Nepal. A cross-sectional survey design was employed, using multi-stage random sampling with data collected from 379 children. Information on the children’s socio-economic and demographic status, as well as their stage of cognitive development, was gathered through scheduled interviews and direct observation. Nutritional status was assessed using anthropometric measurements, specifically Height-for-Age (HAZ) and Weight-for-Age (WAZ), which emerged as significant predictors of cognitive development. Better nutritional status was strongly correlated with higher cognitive development scores. Family structure also played a critical role, with children from joint families exhibiting lower cognitive development scores. Age was a marginally significant factor, indicating a slight decline in cognitive development as children grew older. The findings emphasize the need for interventions targeting improved child nutrition and addressing family dynamics alongside policies that promote equitable educational opportunities. These results provide valuable insights into how nutrition, family structure, and age influence early childhood cognitive development, informing strategies for effective interventions and policy recommendations. Public health authorities should focus on enhancing the educational and nutritional status of preschoolers, as preschool significantly impacts their cognitive and productive development.
Impact of Radix Astragali and Panax natoginseng on Short-Term Outcomes in Acute Kidney Injury: A Retrospective Study
Authors: zhao yan
Published: February 2025

Background: Acute kidney injury (AKI) is a global health concern with limited treatment options. Radix Astragali and Panax notoginseng, widely used in Chinese herbal medicine, have shown nephroprotective potential. This study evaluated their impact on AKI recovery.Methods: A retrospective study was conducted at our Hospital(2012–2022). Univariate and multifactor logistic regression analyses assessed the effects of Radix Astragali and Panax notoginseng on short-term AKI outcomes.Results: Radix Astragali (RR=0.33, P=0.01, 95%CI:[0.13, 0.53]) and its combination with Panax notoginseng (RR=0.31, P=0.01, 95%CI:[0.11, 0.50]) significantly improved AKI recovery. Other positive factors included albumin levels (RR=0.02, P=0.03), ICU admission (RR=0.43, P=0.01), hemoglobin levels (RR=0.01, P=0.01), and diabetes mellitus (RR=0.22, P=0.04).Conclusion: Radix Astragali and Panax notoginseng enhance AKI recovery, particularly at peak serum creatinine levels, suggesting their potential as therapeutic options for AKI management.
How Does a Porcine Herpesvirus, PCMV/PRV, Induces a Xenozoonosis
Authors: Denner Joachim
Published: February 2025

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV), a porcine herpesvirus, has been shown to significantly reduce the survival time of porcine xenotransplants in non-human primates. The virus was detected in all examined organs of baboons transplanted with PCMV/PRV-positive organs and it was also transmitted to the first human recipient of a pig heart, contributing to the patient’s death. PCMV/PRV induces consumptive coagulopathy and thrombocytopenia in xenotransplant recipients. Initial studies in baboons revealed that the virus triggers increased release of tumor necrosis factor α (TNFα) and interleukin 6 (IL-6), along with elevated levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) complexes. This suggests a complete loss of endothelial cells' pro-fibrinolytic function. Although there is no evidence that PCMV/PRV infects primate cells, including human cells, the virus appears to directly interact with immune and endothelial cells, disrupting cytokine signaling and coagulation pathways. Since it affects only xenotransplant recipients and not healthy humans, this condition should be classified as a xenozoonosis. Interestingly, antibodies against human herpesvirus 6 (HHV-6) cross-react with PCMV/PRV and may contribute to protection against infection in humans. Further research is needed to uncover the molecular mechanisms underlying this xenozoonotic disease.
Energy Transition for Sustainability: Addressing Pollution and Climate Adaptation in Developing Countries
Authors: Mtiraoui Abderraouf Ahmed , Chemli Leila , Snoussi Abdelmonem
Published: February 2025

This study explores the impact of the energy transition on sustainable development in developing countries, focusing on pollution reduction, climate adaptation, and resilience. From 2000 to 2022, international funding, incentive policies, and capacity-building initiatives enabled the deployment of solar panels and small wind turbines, fostering job creation, reducing emissions, and improving energy access. A simultaneous equations model is used to examine the interactions between economic, institutional, social, and environmental factors. The research highlights the role of renewable energy, innovative policies, and localized initiatives in driving sustainable progress. Findings demonstrate how clean energy reduces greenhouse gases, strengthens institutional frameworks, and improves living conditions for vulnerable groups. Special attention is given to rural and isolated areas, where renewable energy fosters socio-economic and environmental benefits.
PUSHPA – Predictive UAV & Smart Headset for Pyro Alerting
Authors: Gupta Aditya , Rong Ryan , Suda Chandra , Surana Shamit
Published: February 2025

Firefighters and first responders operate under conditions that demand real-time situational awareness. We propose PUSHPA, an AI-driven system integrating wearable edge computing (Meta Glasses) and autonomous drones for rapid on-site perception and decision-making. This paper provides an extensive technical overview of PUSHPA’s architecture, including convolution-based optimizations for embedded hardware, an AI agentic layer using LangChain for natural language understanding, and integration with WhatsApp for intuitive, conversational control. We highlight data pipelines, security, and multi-modal capabilities (vision, text, voice). Detailed code snippets illustrate how the system handles real-time drone autonomy, glasses-based computer vision, and user queries via messaging interfaces. We also showcase real-life research examples and discuss future applications of this integrated AI approach for disaster response, industrial inspections, and beyond.
Housing in Urban Rehabilitation Areas: Opportunities for Local Management in Housing Promotion
Authors: Ornelas Cilisia Duarte , Figueiredo Carlos , Morgado Ana
Published: February 2025

In Portugal, and at the Municipal level, the housing development is linked with territorial management tools, being the Urban Rehabilitation Operations (ORU) procedures one of these tools at local level management. This study aims to do a critical analysis of the outputs from five Urban Rehabilitation Areas (ARU) in different municipal contexts (settlements and city centres) in Portugal, namely: Belmonte, Soure, Penacova, Vila Real, and Devesas. The analysis will be focused in the: i) selection of one ARU for each municipality; ii) principal outcomes of the strategic plans for each ARU; iii) success of the ORU’ strategies to housing promotion and management; and iv) management of the housing conditions and quality of life to the residents. It will be highlighted the benefits of the Local Housing Strategies (ELH) in housing promotion, incorporating the Recovery and Resilience Plan (PRR) funds in urban regeneration, which address the damage caused by the pandemic crisis, and following the European Commission guidelines.
4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study
Authors: da Fonsêca Diogo Vilar , Rocha Juliana Sousa , de Sá Novaes Pereira Hugo Natan , dos Santos Lucas Vinicius Novaes , de Santana Melquisedec Abiaré Dantas , Alves Alan F. , Pontes Adiel H. O. , Gomes Joás de Souza , Felipe Cícero F. Bezerra , da Silva Pablo R. , de Sousa Damião Pergentino , Scotti Marcus T. , Scotti Luciana
Published: February 2025

Chronic pain significantly impacts quality of life and is often accompanied by inflammation, a natural bodily response that can become harmful when excessive. The orofacial region is commonly affected, making effective treatment crucial. However, current drugs often cause undesirable side effects, highlighting the need for new pharmacological alternatives. 4-hydroxycoumarin (4-HC), a natural compound, has shown promising antinociceptive and anti-inflammatory effects, but studies confirming its specific properties are limited. In silico analyses suggest that 4-HC exhibits favorable pharmacokinetic characteristics, not interacting with P-glycoprotein and successfully crossing the blood-brain barrier. Molecular docking studies indicate that its effects may be mediated through NMDAR or by inhibiting iNOS. Our study assessed the antinociceptive and anti-inflammatory effects of 4-HC in animal models at doses of 25, 50, and 75 mg/kg. 4-HC significantly reduced abdominal contortions induced by acetic acid and decreased nociceptive rubbing in orofacial pain models induced by formalin, glutamate, and capsaicin. Interactions with opioid receptors were not observed, suggesting that 4-HC’s antinociceptive effect does not involve this pathway. Additionally, 4-HC reduced paw edema induced by carrageenan and significantly decreased leukocyte migration and TNF-α levels. These findings highlight the therapeutic potential of 4-HC and warrant further investigation into its mechanisms.
COVID-19 and the Merit-Order Effect through Wind Energy: The case of Nord Pool Electricity Markets
Authors: Guerdalli Seifeddine , Trabelsi Emna
Published: February 2025

The COVID-19 pandemic has had profound consequences on global economies, with the electricity sector being no exception. Volatility in electricity prices has become a key concern for policymakers striving to maintain energy security and economic stability. To mitigate the health crisis, governments implemented strict containment measures, including lockdowns, social distancing, and event cancellations. These interventions, while essential for public health, also disrupted energy demand and supply patterns. This study supports regulators by quantifying the short- and long-term impacts of the pandemic on local electricity prices (LEP) in the Nord Pool market (Norway, Sweden, Denmark, Finland, Estonia, Latvia, and Lithuania) during 2020. The findings highlight a crucial link between crisis response strategies and the transition to sustainable energy systems. In times of uncertainty, governments tend to prioritize renewable energy investments, particularly wind power, which offers a clean and resilient alternative to fossil-fuel-based electricity generation. Using the PMG-ARDL estimator, our analysis reveals a significant long-term negative association between government interventions and LEP, as well as between wind energy production (WEP) and LEP. Specifically, an additional gigawatt of wind energy generation reduces local electricity prices by up to €0.09, confirming the merit-order effect in both short- and long-term horizons. These findings emphasize the environmental and economic benefits of expanding wind energy capacity as a stabilizing force in electricity markets. Moreover, while health-related news influenced LEP fluctuations over the long run, government restrictions had a limited short-term impact, likely due to the inelastic nature of electricity demand and supply. This study reinforces the argument that integrating more renewable energy sources can enhance market resilience, reduce price volatility, and contribute to long-term sustainable development, making the energy transition an essential pillar of post-pandemic recovery strategies.
Cancer Risk Associated with Residential Proximity to Municipal Waste Incinerators: A Review of Epidemiological and Exposure Assessment Studies
Authors: Domingo Jose L
Published: February 2025

Municipal Solid Waste Incinerators (MSWIs) are facilities designed to burn municipal solid waste to reduce its volume and mass and generate energy. A significant concern related to MSWIs is the emission of toxic and carcinogenic pollutants, including polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), heavy metals, and particulate matter. This review synthesizes global epidemiological and exposure assessment studies investigating cancer risks associated with residential proximity to MSWIs. Findings reveal a complex relationship: older incinerators with high emissions correlate with elevated risks of non-Hodgkin lymphoma (NHL), soft-tissue sarcoma (STS), and liver cancer in some studies, particularly in Europe. However, results remain inconsistent due to methodological limitations such as exposure misclassification, latency periods, and confounding factors like socioeconomic status. Modern facilities equipped with advanced pollution control technologies demonstrate reduced risks, often within regulatory thresholds. Key challenges include accurately quantifying historical exposures and disentangling MSWI-specific risks from other environmental or lifestyle factors. While advancements in dispersion modeling and biomonitoring have improved risk assessments, geographical and temporal variations in findings underscore the need for continued research. The review concludes that while historical evidence suggests potential cancer risks near older MSWIs, stricter emissions regulations and technological improvements have mitigated health impacts, although vigilance through long-term monitoring remains essential to safeguard public health.
Development of a Body-Worn Textile-Based Strain Sensor: Application to Diabetic Foot Assessment
Authors: Turnbull Rory Peter , Corser Jenny , Orlando Giorgio , Venkatraman Prabhuraj , Yoldi Irantzu , Bradbury Kathrine , Reeves Neil D , Culmer Peter
Published: February 2025

Using body-worn sensors in healthcare can bring yield clinically valuable information but risks affecting the interface under investigation. Diabetic foot ulcers (DFUs) are a significant health and economic burden, frequently leading to limb amputation with a severe impact on patient quality of life. Clinicians and patients urgently require information about foot condition to inform DFU prevention strategies, but the addition of sensors at the foot interface risks causing inappropriate loads and adverse clinical outcomes. This work proposes a novel strain-sensing technology that can be integrated unobtrusively within sock textiles at the foot interface.
Context-specific set of requirements were established to evaluate potential sensing modalities. A total of 12 load-sensing methods were identified, not limited to DFU sensing to investigate possible solutions. Candidate technologies we evaluated against the specification and selected a silver-based adhesive exhibiting strain-sensitive resistance.
Sensor development was undertaken through parametric experimental testing using a stretchable textile substrate. A characterisation process determined the sensor has a resolution of 0.013 $\Omega$ in a range of 0 - 430 $\Omega$ and a range of interest of 0 - 20 $\Omega$. The sensors demonstrated the capacity to cover an appropriate measurement range (0 - 12\% strain). Composite reinforcement increased strain capacity to 20\% during quasi-static testing.
After development, the final sensor design performance was asessed, integrating the sensing unit within a knitted structure produced using an industrial sock-knitting machine. The system was evaluated through a cyclic loading regime. A strain threshold of 6\% was determined with a peak sensitivity gradient of 0.3 \textpm 0.02. A dynamic drift of 0.039 to 0.045\% (total range) was identified over usage, with micro-tearing identified as the mechanism of action.
In conclusion, this study demonstrates a viable textile-based strain sensor capable of integration within knitted structures. It provides a promising first step towards developing a sock-based strain sensor to aid the prevention of DFU formation.
Turning Resources into Results: Accelerating Capacity Building in Digital Learning at Njala University
Authors: Dumbuya Emmanuel
Published: February 2025

Njala University is actively integrating digital learning solutions to enhance educational outcomes. This paper examines strategies for transforming available resources into measurable results through capacity-building efforts. Utilizing a mixed-methods approach—including policy analysis, stakeholder interviews, and institutional data review—this paper identify key factors contributing to successful digital capacity building. The findings suggest that strategic resource allocation, collaborative partnerships, and targeted professional development initiatives are critical for sustainable digital transformation in higher education. It discusses implications for digital learning at Njala University and proposes a framework to guide similar institutions.
Steel Moment Frames with RWS Connections: Bilin Parameter Prediction with Machine Learning
Authors: Karami Ali , Tsavdaridis Konstantinos Daniel
Published: February 2025

This paper investigates the seismic performance of Reduced Web Section (RWS) connections in steel moment frames. To be able to evaluate the performance of RWS, a well-established concept involving strategic weakening of beam sections. This paper employs advanced machine learning and deep learning techniques to predict the Ibarra-Medina-Krawinkler (IMK) Bilin parameters for RWS connections across various configurations. A database of 154 specimens from experimental and finite element studies was analysed, focusing on non-composite RWS connections. The study develops and compares multiple predictive models, including Random Forest, Neural Networks, Support Vector Regression, Gradient Boosting, XGBoost, and Deep Learning, to predict IMK Bilin parameters with high accuracy. XGBoost consistently demonstrated superior performance across various metrics. Feature importance analysis revealed complex interactions between geometric properties and connection behaviour, with web slenderness and span-to-depth ratio playing critical roles. Moreover, pushover analyses were conducted on 2-, 4-, 8-, 12-, and 20-story benchmark frames to associate the global seismic behaviour of frames with RWS and RBS connections. Results indicate that RWS connections often provide higher strength and comparable or superior ductility to RBS connections, especially in low to mid-rise structures. All RWS configurations achieved interstory drifts exceeding 4%, meeting ANSI/AISC and EC8 performance targets. This research further contributes to the adoption of RWS connections for retrofitting purposes and provides a robust tool for structural engineers to incorporate these connections into performance-based seismic design.