bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Nucleophosmin 1 (NPM1) Mutation in the Diagnosis and Management of Myeloid Neoplasms
Authors: Kelemen Katalin
Published: January 2022

Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis via chromosomal translocations, deletions, or mutation. Acute myeloid leukemia (AML) with mutated NPM1, a distinct diagnostic entity by the current WHO Classification of myeloid neoplasm, represents the most common diagnostic subtype in AML and is associated with a favorable prognosis. The persistence of NPM1 mutation in AML at relapse makes this mutation an ideal target for minimal measurable disease (MRD) detection. The clinical implication of this is far-reaching because NPM1-mutated AML is currently classified as being of standard risk, with the best treatment strategy (transplantation versus chemotherapy) yet undefined. Myeloid neoplasms with NPM1 mutations and <20% blasts are characterized by an aggressive clinical course and a rapid progression to AML. The pathological classification of these cases remains controversial. Future studies will determine whether NPM1 gene mutation may be sufficient for diagnosing NPM1-mutated AML independent of the blast count. This review aims to summarize the role of NPM1 in normal cells and in human cancer and discusses its current role in clinical management of AML and related myeloid neoplasms.
Correlation between Pitch Impregnation Pressure and Pore Sizes of Graphite Block
Authors: Kim Changkyu , Kwon Woong , Lee Moon Hee , Woo Jong Seok , Jeong Euigyung
Published: January 2022

This study aimed to investigate the effect of impregnation pressure on the decrease in porosity of impregnated bulk graphite. The correlation between pitch impregnation behavior and the pore sizes of the bulk graphite block was studied to determine the optimal impregnation pressure. The densities and porosities of the bulk graphite before and after pitch impregnation under various pressures between 10 and 50 bar were evaluated based on the Archimedes method and a mercury porosimeter. The density increased rates increased by 1.93–2.44%, whereas the impregnation rate calculated from the rate of open porosity decreased by 15.15–24.48%. The density increase rate and impregnation rate were significantly high when the impregnation pressures were 40 and 50 bar. Compared with impregnation pressures of 10, 20, and 30 bar, the minimum impregnatable pore sizes with impregnation pressures of 40 and 50 bar were 30–39 and 24–31 nm, respectively. The mercury intrusion porosimeter analysis results demonstrated that the pressure-sensitive pore sizes of the graphite blocks were in the range of 100–4500 nm. Furthermore, the ink-bottle-type pores in this range contributed predominantly to the effect of impregnation under pressure, given that the pitch-impregnated-into-ink-bottle-type pores were difficult to elute during carbonization.
On the Corrosion Fatigue of Magnesium Alloys Aimed at Biomedical Applications: New Insights from the Influence of Testing Frequency and Surface Modification of the Alloy ZK60
Authors: Linderov Mikhail , Brilevsky Alexander , Merson Dmitry , Danyuk Alexei , Vinogradov Alexei
Published: January 2022

Magnesium alloys are contemporary candidates for many structural applications of which medical applications, such as bioresorbable implants, are of significant interest to the community and a challenge to materials scientists. The generally poor resistance of magnesium alloys to environmentally assisted fracture, resulting, in particular, in faster-than-desired bio-corrosion degradation in body fluids, strongly impedes their broad uptake in clinical practice. Since temporary structures implanted to support osteosynthesis or healing tissues may experience variable loading, the resistance to bio-corrosion fatigue is a critical issue that has yet to be understood in order to maintain the structural integrity and to prevent the premature failure of implants. In the present communication, we address several aspects of the corrosion fatigue behaviour of magnesium alloys, using the popular commercial ZK60 Mg-Zn-Zr alloy as a representative example. Specifically, the effects of the testing frequency, surface roughness and metallic coatings are discussed in conjunction with the fatigue fractography after the testing of miniature specimens in air and simulated body fluid. It is demonstrated that accelerated environmentally assisted degradation under cyclic loading occurs due to a complicated interplay between corrosion damage, stress corrosion cracking and cyclic loads. The occurrence of corrosion fatigue in Mg alloys is exaggerated by the significant sensitivity to the testing frequency. The fatigue life or strength reduced remarkably with a decrease in the test frequency.
Sequential Use of CO2 Laser Prior to Nd:YAG and Dye Laser in the Management of Non-Facial Warts: A Retrospective Study
Authors: Bennardo Luigi , Fasano Gaia , Tamburi Federica , Zappia Elena , Rizzuto Francesco , Nisticò Steven Paul , Cannarozzo Giovanni
Published: January 2022

Background and Objectives: Warts are benign lesions of viral etiology characterized by a hyperkeratotic appearance tending to spread across the skin surface. Various treatments have been proposed to manage this condition, such as acids, imiquimod, photodynamic therapy, cryotherapy, and various lasers. Materials and Methods: In this paper, we describe a combination protocol using CO2 laser prior to Nd:YAG laser for lesions interesting the palmoplantar areas or dye laser for lesions on other skin surfaces in the management of non-facial warts resistant to traditional therapies. In total, 34 patients with 103 warts suffering from wart infection resistant to traditional therapies treated from 1 January 2019 to 1 June 2020 were retrospectively enrolled at the Dermatological Unit of Magna Graecia University (Catanzaro, Italy). Two dermatologists measured clinical results, classifying lesions with complete resolution, partial resolution, or non-responding. Patients at four months follow-up were asked to evaluate their degree of satisfaction with a visual analog scale (VAS). Results: Almost all patients reported the complete resolution of lesions, with no patient reporting scarring. Five patients reported hypopigmentation in the treated areas. The mean satisfaction level was high. Only three patients experienced a relapse of the condition. Conclusions: Using a vascular laser following a CO2 superficial ablation of warts may help reduce the risk of scarring and decrease the incidence of relapses for lesions resistant to traditional therapies. Therefore, more extensive studies will be necessary to confirm the obtained results.
Nematode–Microbe Complexes in Soils Replanted with Apple
Authors: Kanfra Xorla , Wrede Andreas , Moll Julia , Heuer Holger
Published: January 2022

Apple replant disease is a severe problem in orchards and tree nurseries. Evidence for the involvement of a nematode–microbe disease complex was reported. To search for this complex, plots with a history of apple replanting, and control plots cultivated for the first time with apple were sampled in two fields in two years. Shoot weight drastically decreased with each replanting. Amplicon sequencing of the nematode community and co-extracted fungal and bacterial communities revealed significant differences between replanted and control plots. Free-living nematodes of the genera Aphelenchus and Cephalenchus and an unidentified Dorylaimida were associated with replanted plots, as indicated by linear discriminant analysis effect size. Among the co-extracted fungi and bacteria, Mortierella and Methylotenera were most indicative of replanting. Some genera, mostly Rhabditis, Streptomyces and a fungus belonging to the Chaetomiaceae indicated healthy control plots. Isolating and investigating the putative disease complexes will help to understand and alleviate stress-induced root damage of apple in replanted soil.
Effects of Allelochemicals, Soil Enzyme Activities, and Environmental Factors on Rhizosphere Soil Microbial Community of Stellera chamaejasme L. along a Growth-Coverage Gradient
Authors: Cheng Jinan , Jin Hui , Zhang Jinlin , Xu Zhongxiang , Yang Xiaoyan , Liu Haoyue , Xu Xinxin , Min Deng , Lu Dengxue , Qin Bo
Published: January 2022

Allelochemicals released from the root of Stellera chamaejasme L. into rhizosphere soil are an important factor for its invasion of natural grasslands. The aim of this study is to explore the interactions among allelochemicals, soil physicochemical properties, soil enzyme activities, and the rhizosphere soil microbial communities of S. chamaejasme along a growth-coverage gradient. High-throughput sequencing was used to determine the microbial composition of the rhizosphere soil sample, and high-performance liquid chromatography was used to detect allelopathic substances. The main fungal phyla in the rhizosphere soil with a growth coverage of 0% was Basidiomycetes, and the other sample plots were Ascomycetes. Proteobacteria and Acidobacteria were the dominant bacterial phyla in all sites. RDA analysis showed that neochamaejasmin B, chamaechromone, and dihydrodaphnetin B were positively correlated with Ascomycota and Glomeromycota and negatively correlated with Basidiomycota. Neochamaejasmin B and chamaechromone were positively correlated with Proteobacteria and Actinobacteria and negatively correlated with Acidobacteria and Planctomycetes. Allelochemicals, soil physicochemical properties, and enzyme activity affected the composition and diversity of the rhizosphere soil microbial community to some extent. When the growth coverage of S. chamaejasme reached the primary stage, it had the greatest impact on soil physicochemical properties and enzyme activities.
Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms
Authors: Moral Raquel , Escrich Eduard
Published: January 2022

Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as a healthy dietary pattern with protective effects in several chronic diseases, including breast cancer. This diet is characterized by the consumption of abundant plant foods and olive oil as the principal source of fat, which is considered one of the main components with potential antioxidant, anti-inflammatory and anticancer effects. Extra-virgin olive oil (EVOO) has several bioactive compounds, mainly including monounsaturated fatty acids, triterpenes and polyphenols, such as phenolic alcohols (e.g., hydroxytyrosol), secoiridoids (e.g., oleuropein and oleocanthal), lignans (e.g., pinoresinol) or flavonoids (e.g., luteolin). While epidemiological evidence is still limited, experimental in vivo and in vitro data have shown a protective effect of this oil and its compounds on mammary carcinogenesis. Such effects account through complex and multiple mechanisms, including changes in epigenetics, transcriptome and protein expression that modulate several signaling pathways. Molecular targets of EVOO compounds have a role in the acquisition of cancer hallmarks. Although further research is needed to elucidate their beneficial effects on human prevention and progression of the disease, evidence points to EVOO in the context of the Mediterranean diet as a heathy choice, while EVOO components may be promising adjuvants in anticancer strategies.
A Modified Sequential Deposition Route for High-Performance Carbon-Based Perovskite Solar Cells under Atmosphere Condition
Authors: Wu Jinyu , Zhang Lei , Kang Qiao , Shi Hongxi , Li Long , Chi Dan , Huang Shihua , He Gang
Published: January 2022

Carbon-based hole transport material (HTM)-free perovskite solar cells have exhibited a promising commercialization prospect, attributed to their outstanding stability and low manufacturing cost. However, the serious charge recombination at the interface of the carbon counter electrode and titanium dioxide (TiO2) suppresses the improvement in the carbon-based perovskite solar cells’ performance. Here, we propose a modified sequential deposition process in air, which introduces a mixed solvent to improve the morphology of lead iodide (PbI2) film. Combined with ethanol treatment, the preferred crystallization orientation of the PbI2 film is generated. This new deposition strategy can prepare a thick and compact methylammonium lead halide (MAPbI3) film under high-humidity conditions, which acts as a natural active layer that separates the carbon counter electrode and TiO2. Meanwhile, the modified sequential deposition method provides a simple way to facilitate the conversion of the ultrathick PbI2 capping layer to MAPbI3, as the light absorption layer. By adjusting the thickness of the MAPbI3 capping layer, we achieved a power conversation efficiency (PCE) of 12.5% for the carbon-based perovskite solar cells.
Soil Erosion Susceptibility Prediction in Railway Corridors Using RUSLE, Soil Degradation Index and the New Normalized Difference Railway Erosivity Index (NDReLI)
Authors: Ouma Yashon O. , Lottering Lone , Tateishi Ryutaro
Published: January 2022

This study presents a remote sensing-based index for the prediction of soil erosion susceptibility within railway corridors. The empirically derived index, Normalized Difference Railway Erosivity Index (NDReLI), is based on the Landsat-8 SWIR spectral reflectances and takes into account the bare soil and vegetation reflectances especially in semi-arid environments. For the case study of the Botswana Railway Corridor (BRC), the NDReLI results are compared with the RUSLE and the Soil Degradation Index (SDI). The RUSLE model showed that within the BRC, the mean annual soil loss index was at 0.139 ton ha−1 year−1, and only about 1% of the corridor area is susceptible to high (1.423–3.053 ton ha−1 year−1) and very high (3.053–5.854 ton ha−1 year−1) soil loss, while SDI estimated 19.4% of the railway corridor as vulnerable to soil degradation. NDReLI results based on SWIR1 (1.57–1.65 μm) predicted the most vulnerable areas, with a very high erosivity index (0.36–0.95), while SWIR2 (2.11–2.29 μm) predicted the same regions at a high erosivity index (0.13–0.36). From empirical validation using previous soil erosion events within the BRC, the proposed NDReLI performed better than the RUSLE and SDI models in the prediction of the spatial locations and extents of susceptibility to soil erosion within the BRC.
Green Citrus Detection and Counting in Orchards Based on YOLOv5-CS and AI Edge System
Authors: Lyu Shilei , Li Ruiyao , Zhao Yawen , Li Zhen , Fan Renjie , Liu Siying
Published: January 2022

Green citrus detection in citrus orchards provides reliable support for production management chains, such as fruit thinning, sunburn prevention and yield estimation. In this paper, we proposed a lightweight object detection YOLOv5-CS (Citrus Sort) model to realize object detection and the accurate counting of green citrus in the natural environment. First, we employ image rotation codes to improve the generalization ability of the model. Second, in the backbone, a convolutional layer is replaced by a convolutional block attention module, and a detection layer is embedded to improve the detection accuracy of the little citrus. Third, both the loss function CIoU (Complete Intersection over Union) and cosine annealing algorithm are used to get the better training effect of the model. Finally, our model is migrated and deployed to the AI (Artificial Intelligence) edge system. Furthermore, we apply the scene segmentation method using the “virtual region” to achieve accurate counting of the green citrus, thereby forming an embedded system of green citrus counting by edge computing. The results show that the mAP@.5 of the YOLOv5-CS model for green citrus was 98.23%, and the recall is 97.66%. The inference speed of YOLOv5-CS detecting a picture on the server is 0.017 s, and the inference speed on Nvidia Jetson Xavier NX is 0.037 s. The detection and counting frame rate of the AI edge system-side counting system is 28 FPS, which meets the counting requirements of green citrus.
Development Technologies for the Monitoring of Six-Minute Walk Test: A Systematic Review
Authors: Pires Ivan Miguel , Denysyuk Hanna Vitaliyivna , Villasana María Vanessa , Sá Juliana , Marques Diogo Luís , Morgado José Francisco , Albuquerque Carlos , Zdravevski Eftim
Published: January 2022

In the pandemic time, the monitoring of the progression of some diseases is affected and rehabilitation is more complicated. Remote monitoring may help solve this problem using mobile devices that embed low-cost sensors, which can help measure different physical parameters. Many tests can be applied remotely, one of which is the six-minute walk test (6MWT). The 6MWT is a sub-maximal exercise test that assesses aerobic capacity and endurance, allowing early detection of emerging medical conditions with changes. This paper presents a systematic review of the use of sensors to measure the different physical parameters during the performance of 6MWT, focusing on various diseases, sensors, and implemented methodologies. It was performed with the PRISMA methodology, where the search was conducted in different databases, including IEEE Xplore, ACM Digital Library, ScienceDirect, and PubMed Central. After filtering the papers related to 6MWT and sensors, we selected 31 papers that were analyzed in more detail. Our analysis discovered that the measurements of 6MWT are primarily performed with inertial and magnetic sensors. Likewise, most research studies related to this test focus on multiple sclerosis and pulmonary diseases.
Experimental Analysis and Multiscale Modeling of the Dynamics of a Fiber-Optic Coil
Authors: Kahveci Özkan , Gençoğlu Caner , Yalçinkaya Tuncay
Published: January 2022

Fiber-optic gyroscopes (FOGs) are common rotation measurement devices in aerospace applications. They have a wide range of diversity in length and in the winding radius of the coil to meet system requirements. Every dimensional parameter in the coil influences the dynamic response of the system, eventually leading to measurement errors. In order to eliminate the errors and to qualify the system, after the design and production stages, a deep and comprehensive testing procedure follows. In this study, the dynamic behavior of a quadrupole wound fiber-optic coil is investigated. First, pre-wound fiber-optic coils are tested with an impact modal test, where the mode shapes and natural frequencies are determined with structural data acquisition. For the modal analysis, a finite element (FE) model is developed where a representative volume element (RVE) analysis is also included to properly consider the influence of the microstructure. The experimental and numerical results are compared and validated. Moreover, an estimation model is proposed for a type of coil with different fiber lengths. Finally, the estimated coil set is produced and tested employing the same methodology in order to illustrate the capacity of the developed framework.
The Elusive Search for Talent: Skill Gaps in the Canadian Luxury Hotel Sector
Authors: Dimanche Frederic , Lo Katherine
Published: January 2022

The luxury segment of the hospitality sector has been growing worldwide. Luxury hospitality is about providing a unique experience for guests, and this type of experience requires having employees who understand the luxury culture and are trained at the highest level. Luxury hotels compete for the best talents, but the current pool of candidates for customer-facing and managerial positions within these establishments is limited. The purpose of this study was to identify skill gaps in Canada’s luxury hotels. Primary data were collected from in-depth semi-structured interviews with twenty luxury hotel managers and analyzed with NVivo 12. Respondents agreed about the skills required for brands to succeed in the luxury market, but they lamented the lack of qualified talents and the difficulty of training and retaining qualified collaborators. The results of the study point to the need to address the luxury skill gap in the hospitality sector, particularly in Canada. Recommendations to address this problem are proposed.
Scalar Perturbations of Black Holes in the f(R)=R−2αR Model
Authors: Li Ping , Jiang Rui , Lv Jian , Zhai Xianghua
Published: January 2022

In this paper, we study the perturbations of the charged static spherically symmetric black holes in the f(R)=R−2αR model by a scalar field. We analyze the quasinormal modes spectrum, superradiant modes, and superradiant instability of the black holes. The frequency of the quasinormal modes is calculated in the frequency domain by the third-order WKB method, and in the time domain by the finite difference method. The results by the two methods are consistent and show that the black hole stabilizes quicker for larger α satisfying the horizon condition. We then analyze the superradiant modes when the massive charged scalar field is scattered by the black hole. The frequency of the superradiant wave satisfies ω∈(μ2,ωc), where μ is the mass of the scalar field, and ωc is the critical frequency of the superradiance. The amplification factor is also calculated by numerical method. Furthermore, the superradiant instability of the black hole is studied analytically, and the results show that there is no superradiant instability for such a system.
C Proteins: Controllers of Orderly Paramyxovirus Replication and of the Innate Immune Response
Authors: Siering Oliver , Cattaneo Roberto , Pfaller Christian K.
Published: January 2022

Particles of many paramyxoviruses include small amounts of proteins with a molecular weight of about 20 kDa. These proteins, termed “C”, are basic, have low amino acid homology and some secondary structure conservation. C proteins are encoded in alternative reading frames of the phosphoprotein gene. Some viruses express nested sets of C proteins that exert their functions in different locations: In the nucleus, they interfere with cellular transcription factors that elicit innate immune responses; in the cytoplasm, they associate with viral ribonucleocapsids and control polymerase processivity and orderly replication, thereby minimizing the activation of innate immunity. In addition, certain C proteins can directly bind to, and interfere with the function of, several cytoplasmic proteins required for interferon induction, interferon signaling and inflammation. Some C proteins are also required for efficient virus particle assembly and budding. C-deficient viruses can be grown in certain transformed cell lines but are not pathogenic in natural hosts. C proteins affect the same host functions as other phosphoprotein gene-encoded proteins named V but use different strategies for this purpose. Multiple independent systems to counteract host defenses may ensure efficient immune evasion and facilitate virus adaptation to new hosts and tissue environments.
Isolation, Serovar Identification, and Antimicrobial Susceptibility of Avibacterium paragallinarum from Chickens in China from 2019 to 2020
Authors: Guo Mengjiao , Chen Xiufang , Zhang Hao , Liu Donghui , Wu Yantao , Zhang Xiaorong
Published: January 2022

Infectious coryza is an acute infectious respiratory disease in chickens that is caused by Avibacterium paragallinarum (A. paragallinarum). Infectious coryza has major economic effects due to decreased egg production in growing birds and slowed growth in broilers. In this study, we isolated and identified 40 strains of A. paragallinarum from chickens that showed typical clinical signs of coryza in part of China from 2019 to 2020. Using a hemagglutination-inhibition test, 11 isolates were identified as serovar A, 10 isolates were identified as serovar B, and 19 isolates were identified as serovar C. Antimicrobial sensitivity tests showed that high minimum inhibitory concentration (MIC) values were encountered for compounds sulfamethoxine sodium and oxytetracycline hydrochloride. Especially, of the 40 A. paragallinarum isolates, 30% had an MIC value of compound sulfamethoxine sodium of 64 μg/mL, 10% of 128 μg/mL, and 15% of 256 μg/mL. For oxytetracycline hydrochloride, 85% of isolates showed MIC values of 64 μg/mL or more. Excitingly, the MIC values of β-lactamase (amoxicillin, ampicillin, and ceftiofur) were low, with 77.5%, 70%, and 92.5% of isolates having an MIC value of ≤1 μg/mL, respectively. Our results may provide a reference for the treatment of infectious coryza.
Immunological features of chronic endometritis
Authors:   Group of Companies “Medsi”, reproductive Health Center, Moscow, Sorokin Yuriy Aleksandrovich
Published: January 2022

Chronic endometritis is a clinical and morphological syndrome with a complex of morphological and functional changes in the endometrium, leading to a violation of the physiological cyclic transformation and receptivity of endometrial tissues. The treatment of chronic endometritis requires special consideration. Despite the progress of pharmacotherapy, there are significant methodological and practical difficulties. Cavitated solutions, low-intensity ultrasound effects, and photochromotherapy increase the effectiveness of the treatment of chronic endometritis and female infertility.
recirculación del agua residual industrial en el costo de reúso del proceso
Authors: Córdova Mendoza Pedro , Barrios Mendoza Teresa Oriele , Córdova Barrios Isis Cristel , Calderón Huamani Dante Fermín
Published: January 2022

El objetivo de la investigación fue evaluar la recirculación del agua residual industrial y su influencia en el costo de reúso del proceso. Material y métodos la investigación realizada fue de tipo experimental, nivel descriptivo- explicativo, investigación aplicada. Resultados la norma DS N°003-2002- PRODUCE, establece los Límites Máximos Permisibles y Valores Referenciales para la actividad industrial de curtiembre con un pH entre 6-9, temperatura 35°C, se dispuso la herramienta MATLAB, que recoge toma de pruebas del  proceso  de la curtiembre, como lo indica las coordenadas UTM. Los costos totales (S/d): 1945.36 a 1870.98, dependiendo del reciclo del agua residual (X1) de 0.6 a 0.75, la carga de retiro de la planta de tratamiento (X2): 33.22 Kg/h a 39.41 Kr/h y la carga de retiro en la descarga a la fuente (X3): 19.72 Kg/h a 10.57 Kg/h. Discusión se evidenciaron que los tratamientos X1, X2, X1 X2, influenciaron en los costos de reúso del proceso. Conclusión el análisis del costo de reúso del proceso depende del porcentaje de reciclo del agua residual de la planta de tratamiento, del porcentaje de retiro en la planta de tratamiento y de ambos tratamientos como el reciclo y del porcentaje de retiro en la planta de tratamiento.
Valoración social económica ambiental de los incendios forestales
Authors: Cueva Toalombo Jaime , Salguero Marita , Caiza Criollo Elvia
Published: January 2022

En la  investigación  desarrollada sobre la valoración socio económica ambiental de los incendios forestales, en la provincia de Imbabura, se realizó una valoración económica ambiental utilizando la metodología proporcionada por el Ministerio Ambiental con plantaciones forestales de Eucalyptus globulus; a través de un estudio se logró determinar que los bosques andinos nativos presentan un valor económico ambiental de 77783,4 USD/ha, el mismo que es superior al de las plantaciones forestales que tienen 46344,1 USD/ha y 45471,9 USD/ha. Por otro lado, también se encontró que la producción de biomasa es netamente superior en las plantaciones forestales que, en los bosques nativos (E. globulus 492,59 ton/ha, P. patula 333,8 ton/ha y Bosques nativos 151,91 ton/ha), con cantidades que superan  más del 50% y que, además se ve reflejado en el almacenamiento de carbono, ya que las plantaciones forestales al tener mayor producción de biomasa, también retinen mayor cantidad de carbono (E. globulus con 246,30 ton/ha, P. patula con 166,93 Bosque y andino 75,96 ton/ ha).
Trabajo en equipo y formación continua en estudiantes del doctorado en educación de la UNMSM
Authors: Huamaní Huamán Luis Héctor , Gallegos Ruíz Conejo Ada Lucía
Published: January 2022

El trabajo en equipo es  concebido como una estrategia de aprendizaje que permite la actualización continua de los diferentes contenidos procedimentales, actitudinales y conceptuales de los docentes. En este sentido, el objetivo planteado fue establecer la relación existente entre el trabajo en equipo y la formación continua en los estudiantes del Doctorado en Educación y Docencia Universitaria de la  Universidad Nacional Mayor de San Marcos. La metodología del presente trabajo tiene un enfoque cuantitativo, el alcance de la investigación es descriptiva correlacional y cuenta con un diseño no experimental de tipo transversal. El resultado del Chi cuadrado de Pearson del cuestionario como de la escala Likert es menor a 0.05. Esto permite concluir que la variable independiente y dependiente guardan relación positiva. Además, el coeficiente de correlación de Spearman revela un mayor grado de correlación entre las variables.
Jaringan Syaraf Tiruan Untuk Memprediksi Nilai Siswa SMA Menggunakan Backpropagation
Authors: Damanik Evan Hikler , Irawan Eka , Rizki Fitri
Published: January 2022

A student's mastery of a subject greatly influences the marking given by the teacher / teacher concerned. The need for instructors or teachers to monitor every value of students who are taught science in their respective fields. With the rapid development of technology, it is very helpful for teachers in knowing or predicting the value that students will get related. This study aims to apply the performance of backpropagation artificial neural networks in predicting the value of students of SMA N 1 Sidamanik with various models and minimizing their errors. In this study the authors used data on student grades from SMA N 1 Sidamanik. In processing data values, the authors use artificial neural networks with backpropagation algorithms as logical steps to predict student National Exam Scores in SMA N 1 Sidamanik. The main problem in this study is the decline in student grades in some subjects, in the future students will experience difficulties in reaching the desired university or high school.
Tumor de células granulares en esófago Presentación de caso y revisión de literatura
Authors: Caro Porras Nicole , Alvarado Salazar Marianela
Published: January 2022

El tumor de células granulares o de Abrikossoff es un tumor infrecuente. Usualmente es benigno, pero existen casos documentados de malignidad. Puede encontrarse en cualquier localización anatómica, y se sabe que posee derivación neural. Un 4-6% se localiza en el tracto gastrointestinal y un tercio de ellos, en esófago. Es un tumor usualmente asintomático, por lo que la mayoría se diagnostica en endoscopías realizadas por otras causas. La edad de diagnóstico es alrededor de los 30-60 años. Macroscópicamente, se observa como una masa sésil, firme, blanco-amarillenta y está localizada principalmente en submucosa. A la histología e inmunohistoquímica se documenta granulaciones y positividad para S-100 y PAS diastasa resistente. En este trabajo se presenta un caso de tumor de células granulares de esófago con características típicas descritas en la literatura, diagnosticado en el Hospital Escalante Pradilla. A nuestro conocimiento, es el primer tumor de Abrikossoff de esófago reportado en Costa Rica.
Periodontal Disease an Overlooked Chapter in Public Health: A Statistical Analysis
Authors: Sheth Dr. Arpan , Patel Ritul , Patel Shivam
Published: January 2022

This study aims to find that there is any association between Periodontal diseases with factors like diabetes, depression, blood pressure, age, gender, alcohol, smoking, education level, and obesity. For this study data were taken from National Health and Nutrition Examination Survey (NHANES). From this data various variables are taken and test in SAS 9.4 software for analysis. This study is done on a 3737 sample in which 734 people reported having gum/periodontal disease. Logistic regression analysis was performed with variables. We found a significant association between diabetes, depression, age, smoking, and obesity to have periodontal disease.
Geriatric aspects of modern plastic surgery
Authors: Алиханов Б.Г. , Иорданишвили А.К. , Павлова С.Г. , Юшкова И.Д.
Published: January 2022

Старение организма человека - закономерный физиологический процесс. В прошлом веке основными причинами обращения людей к пластическим хирургам служили врожденные и приобретенные деформации, а также возрастные изменения кожи лица. В наши дни внешний вид человека стал основным фактором его успешности в обществе. В работе определена мотивация людей пожилого и старческого возраста к выполнению пластических операций, а также проанализирована работа клиник по выполнению пластических операций людям старших возрастных групп. Установлено, что 96,4 % мужчин и 86,9 % женщин старших возрастных групп имеют достаточно полные представления о пластической хирургии. 27,7 % мужчин и 17,2 % женщин пожилого и старческого возраста хотели бы сделать себе пластическую операцию, однако женщины в 10,9 раза чаще обращаются к пластическим хирургам. Анализ работы клиник пластической хирургии показал устойчивую тенденцию увеличения обращаемости людей пожилого и старческого возраста, независимо от пола, к пластическим хирургам для выполнения операций, направленных, главным образом, на улучшение эстетики лица, шеи и коррекцию фигуры путем устранения гравитационного птоза и удаления избыточных подкожных жировых отложений на туловище. Основной причиной отказа от выполнения желаемой пациентом и рекомендуемой пластическим хирургом операции является недостаток денежных средств.

Aging of the human body is a natural physiological process. In the last century, the main reasons for people turning to plastic surgeons were congenital and acquired deformities, as well as age-related changes in the skin of the face. Nowadays, a person’s appearance has become the main factor in his success in society. The work determines the motivation of elderly and senile people to perform plastic surgeries, and also analyzes the work of clinics in performing plastic surgeries for people of older age groups. It was found that 96,4 % of men and 86,9 % of women in older age groups have a fairly complete understanding of plastic surgery. Among the elderly and old people, 27,7 % of men and 17,2 % of women have a desire to perform plastic surgery for themselves, however, women are 10,9 times more likely to go to plastic surgeons. Analysis of the plastic surgery clinics showed a steady trend of increasing the number of elderly and senile people, regardless of gender, to plastic surgeons to perform operations aimed mainly at improving the aesthetics of the face, neck and body shaping by eliminating gravitational ptosis and removing excess subcutaneous fat. deposits on the trunk. The main reason for refusal to perform the operation desired by the patient and recommended by the plastic surgeon is the lack of funds.
Modeling and empirical verification of dependences of the influence of socio-economic situation of elderly persons on the level of resilience
Authors: Иванкина Л.И. , Клемашева Е.И. , Кашапова Э.Р. , Аникина Е.А.
Published: January 2022

В работе проведен эмпирический анализ влияния на уровень жизнестойкости параметров социально-экономического положения людей пожилого возраста на основе данных социологического опроса. Моделирование исследования включало выбор переменных с учетом критерия комплексности измеряемых параметров. Эмпирической базой для исследования являлись результаты анкетирования лиц пожилого возраста (выборочная совокупность 400 человек), проживающих в городах и сельской местности Томской обл. Для тестирования гипотез использовали моделирование и корреляционный анализ. Для выявления зависимости применена формальная модель взаимосвязи жизнестойкости с выделенными параметрами социально-экономического положения как системы показателей, к которым применимы методы математической статистики для выявления их влияния на укрепление жизнестойкости пожилых людей. Результаты исследования подтверждают влияние удовлетворенности материальным достатком на жизнестойкость людей пожилого возраста. Выявлены корреляции жизнестойкости и разных параметров, в том числе пола, места проживания и высшего образования.

The work carried out an empirical analysis of the impact on the level of vitality of the parameters of the socio-economic situation of elderly people based on the data of a sociological survey. The modeling of the study of the influence included the choice of variables taking into account the criterion of the complexity of the measured parameters. The empirical basis for the study was the results of a survey (n=400) of elderly people living in cities and rural areas of the Tomsk region. Modeling and correlation analysis are used to test hypotheses. To identify the dependence, a formal model of the relationship of resilience with the selected parameters of the socio-economic situation is used as a system of indicators, to which the methods of mathematical statistics are applied to identify their impact on strengthening the resilience of older people. The results of the study confirm the influence of satisfaction with material prosperity on the resilience of elderly people. Correlations of resilience with different parameters, including gender, place of residence and higher education, were revealed.
Los gobiernos locales como titulares de la reparación civil en los procesos penales por los delitos ambientales
Authors: Marroquín Córdova Ángela Milagros
Published: January 2022

El deber de preservar y proteger el ambiente es una obligación que trasciende los tres niveles de gobierno del Estado peruano, es decir, el gobierno central, los gobiernos regionales y los gobiernos locales. La defensa del Estado en los procesos penales por delitos ambientales la ejerce la Procuraduría Especializada en Delitos Ambientales; sin embargo, corresponde a los gobiernos locales y las municipalidades distritales o provinciales percibir la indemnización que se fije en estos procesos para ser empleada en la reparación del daño ocasionado o en la conservación del medio ambiente de su circunscripción, ello por cuanto son las instancias de gobierno las que deberán asumir todos los efectos sociales que ocasione el daño ambiental en sectores como salud y trabajo y en el desarrollo de su municipio.
El principio de confianza y la responsabilidad de los funcionarios públicos en las investigaciones por delitos forestales
Authors: Espinoza Caro Danilo Roldan
Published: January 2022

La aplicación del principio de confianza no es una regla general, ya que presenta límites, por lo que su invocación y su aplicación no deben ser obligatorias, mucho menos cuando nos encontramos frente a modelos de investigación penal forestal. En el presente artículo se intenta clarificar el correcto uso y aplicación del principio de confianza en las investigaciones y los procesos judiciales que se siguen contra funcionarios públicos por la imputación del delito de responsabilidad de funcionario público por otorgamiento ilegal de derechos, signado en el artículo 314 del Código Penal.
Analisis Produktivitas dan Pendapatan Petambak Garam di Kabupaten Jeneponto Provinsi Sulawesi Selatan
Authors: Leo B. Aswar , Suro Adhwati Sri , Asnawi Aslina
Published: January 2022

Peningkatan produktivitas garam dapat dilakukan dengan cara mengoptimalkan faktor produksi garam. Pada umumnya, produksi berbanding lurus dengan penerimaan yang juga akan berpengaruh pada pendapatan. Semakin meningkat output produksi yang dihasilkan maka semakin meningkat penerimaan petambak tersebut dengan asumsi harga garam tidak mengalami penurunan. Faktor harga merupakan hal yang sulit dikendalikan petambak. Biasanya harga garam ditentukan oleh pasar atau harga yang telah ditetapkan sehingga petambak hanya bisa berusaha dalam meningkatkan produksi yang dihasilkan. Permasalahan yang terjadi mengakibatkan perubahan pada pendapatan petambak. Oleh karena itu diperlukan penelitian yang dapat membuktikan bahwa apakah faktor produksitivitas mempengaruhi pendapatan petambak garam di Kabupaten Jeneponto Provinsi Sulawesi Selatan. Tujuan yang akan dicapai pada penelitian ini adalah Mengetahui apakah ada hubungan antara produktivitas dan pendapatan petambak di Kabupaten Jeneponto. Hasil peneitian diperoleh informasi nilai korelasi person antara variabel produktivitas dengan variabel pendapatan sebesar 0.728. Oleh karena nilai korelasi berada di range 0.60 - 0.799 maka dapat disimpulkan bahwa hubungan antara variabel produktivitas dengan variabel pendapatan adalah kuat.
Pengaruh Pemberian Pupuk Kandang Ayam Terhadap Pertumbuhan dan Hasil Tanaman Sawi Pakcoy (Brassica Chinensis L.)
Authors: Wedhu Inosensius Y. , Beja Henderikus Darwin , Wahyuni Yuyun
Published: January 2022

Sawi Pakcoy (Brassica chinensis L) is one of the horticultural plants of the Brassicaceae family which is still in the same genus as mustard greens and mustard greens, Sawi pakcoy is a plant that is quite popular and widely consumed by the public because it is very good for health and has high nutritional content. The purpose of this study was to determine the effect of giving chicken manure on the growth and yield of pakcoy (Brassica chinensis L.) plants. The method used in this study was a randomized block design (RBD) with four replications and six treatments, namely, P0: 0 tons / ha or without fertilizer, P1: 20 tons / ha, P2: 30 tons / ha, P3: 40 tons / ha, P4: 50 ton / ha, P5: 60 ton / ha. Based on the results of the analysis of variance using a randomized block design (RBD), it was found that the application of chicken manure had no significant effect on plant height, number of leaves, and had a very significant effect on fresh weight of Tan-1, and fresh weight of ha-1. The optimum dose of chicken manure 60 tons / ha is the best treatment for optimal growth and yield of pakcoy (Brassica chinensis L.) plants with an average production of fresh weight ha-1 reaching 52.47 tons ha-1.
Meningkatkan Kemandirian Belajar Mahasiswa Pendidikan Matematika di Masa Pandemi Covid-19 melalui Pembelajaran Blended Learning
Authors: Ode Rasid , Kasriana Kasriana , Zurimi Safarin
Published: January 2022

This research was conducted at Darussalam University Ambon with the research subjects being students of mathematics education in the third semester of the academic year 2021/2022. This study aims to determine student responses to learning independence through blended learning using several indicators of learning independence. The results showed that most (80%) students in the third semester of the Mathematics Education Study Program at the University of Darussalam Ambon were in the good category with the following description: : (1) 69% of students have learning initiatives; (2) diagnose the learning needs of 76% of students; (3) setting the target or learning objectives owned by students as much as 73%; (4) monitor, regulate and control 81% owned by students; (5) views difficulties as challenges that are owned by 73% of students; (6) utilize and look for relevant sources owned by students as much as 75%; (7) choose and apply learning strategies owned by students as much as 77%; (8) evaluate the process and learning outcomes owned by students as much as 75%; (9) students' self-efficacy (self-concept) is 78%.
PERAN BIDAN TERHADAP PELAKSANAAN PROGRAM PERENCANAAN PERSALINAN DAN PENCEGAHAN KOMPLIKASI (P4K) DALAM MENURUNKAN ANGKA KEMATIAN IBU
Authors: Herlina Siskha Maya , Zulviana Yesvi , Ulya Yadul
Published: January 2022

Maternal Mortality Rate in Indonesia in 2012 that there were 359. In 2007 the Minister of Health planned a delivery planning and complication prevention program (P4K) as an effort to accelerate the decline in MMR in Indonesia. Health workers have a role in carrying out labor preparation and preparation for pregnant women. This program is one of the effective strategies to reduce the number of maternal deaths, besides childbirth assisted by trained midwives also plays a role in reducing maternal morbidity and mortality. Program Implementation Planning Childbirth Complications and Prevention (P4K) on Reducing Maternal Mortality Rate (MMR) Methods phenomenological design, using descriptive data involving  informants. The collection of data with verification, data presentation and verification. Results In this study Generally P4K implementation is good enough. Services and cooperation of midwives, as well as the role of all the informant was quite good, facilities are adequate, but there are some activities that still has not been implemented because some of the barriers that exist so that the implementation is not optimal. Conclusions Implementation P4K program is likely to have contributed in helping pregnant women prepare for childbirth, and to reduce maternal mortality (MMR) should be reconsidered from various aspects
Pengaruh Bimbingan Imajinasi Terhadap Penurunan Stress Hospitalisasi Pada Anak Usia Sekolah 7-12 Tahun
Authors: Niar Niar , Firna Fransiska
Published: January 2022

Stres Hospitalisasi adalah pengalaman yang tidak menyenangkan disebabkan ketidaksesuaian kondisi individu dengan lingkungan yang disertai adanya perubahan tingkah laku. Tujuan Penelitian ini adalah untuk mengetahui Pengaruh bimbingan imajinasi terhadap penurunan stress hospitalisasi pada anak usia sekolah 7-12 Tahun di Ruang PerawatanAsoka di RSUD Polewali Mandar.  Bimbingan imajinasi adalah teknik yang dapat digunakan dirumah dan dapat membantu untuk bersantai serta menyingkirkan beban pikiran atau stress yang sedang dialami. Penelitian ini merupakan penelitian Eksperimen dengan desain penelitian adalah quasy experiment dengan rancangan pre dan post test. Tekhnik sampling yang digunakan pada penelitian ini adalah Accidental Sampling dengan subjek penelitian sebanyak 22 responden. Dalam penelitian ini pengumpulan data menggunakan lembar observasi. Analisis data menggunakan uji Mc-Nemar untuk melihat pengaruh pada satu varaibel pengukuran dengan tingkat kemaknaan α=0,05. Hasil pengolahan data yang dilakukan dengan menggunakan analisa data dengan uji Mc Nemar yang menunjukkan ada Pengaruh Bimbingan Imajinasi terhadap Penurunan Stress Hospitalisasi dengan tingkat signifikan p=0,000
HUBUNGAN DIMENSI KUALITAS PELAYANAN DENGAN KEPUASAN PASIEN RAWAT INAP PADA RSUP DR TADJUDDIN CHALID MAKASSAR
Authors: Nurhasma Nurhasma , Rijal Andi Syamsul , Azis Rahmawati
Published: January 2022

Quality in a Hospital Service is closely related to Inpatient Patient Satisfaction in Hospitals in Indonesia. Patient satisfaction is one of the important indicators to control the quality of health services in hospitals. The results of the study indicate that the level of patient satisfaction in several hospitals in Indonesia is still below the standard set by the government (>90%). The purpose of this study was to determine the relationship between the dimensions of the quality of health services with the satisfaction of inpatients at the hospital. Data analysis used univariate, bivariate (Chi-Square test) and multivariate (Logistic Regression test) analysis. The results showed that the level of patient satisfaction was 96.6%, this means that the satisfaction level of inpatients in hospitals in Indonesia is good because it meets the customer satisfaction standards set by the Indonesian Ministry of Health (>90%). Multivariate analysis showed a significant relationship between, service, environment and hospital facilities. The results of this study can be concluded that the quality of health services received by atients is very influential on patient satisfaction itself