bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining The Effect of School Principals' Democratic Attitudes On Teachers' Perceptions of Organizational Alineation
Authors: ASLAN Hüseyin , DOĞAN Ümit , AKBULUT Ezgi
Published: September 2023

This study examined the effect of school principals' democratic attitudes on teachers' perceptions of organizational alienation. The survey method was used in the research, and the study population consisted of 7455 teachers working in Sakarya province. In comparison, the sample selected based on a simple random sampling technique consisted of 410 teachers. It was found that participant teachers perceived school principals' democratic attitudes as moderate level. Furthermore, teachers' perceptions of school principals' democratic attitudes and organizational alienation did not differ statistically regarding their gender and professional experience. In contrast, their perceptions differed in terms of school level. At the end of the research, it was reached that teachers' perceptions of organizational alienation correlated statistically positively with school principals' democratic attitudes. School principals' democratic attitudes could explain 9% of the variance in teachers' perceptions of organizational alienation. In light of these findings, school principals should create environments where teachers can express themselves freely and use horizontal and vertical communication channels effectively. Further, teachers should take part in professional team projects with school principals, where they can be involved in decision-making processes to increase their perceptions of school principals’ democratic attitudes. Based on all findings obtained in the study, school principals should create environments where teachers can express themselves freely and use both horizontal and vertical communication channels effectively. Further, teachers should take part in professional team projects with school principals, where they can be involved in decision-making processes to increase their perceptions of school principals' democratic attitudes.
A ESTIGMATIZAÇÃO DO FEMINISMO: O IMPEDIMENTO AO DIREITO À MANIFESTAÇÃO DAS ATIVISTAS FEMINISTAS NO BRASIL ENTRE 2000 E 2020
Authors: Modernel Raquel de Oliveira , Gomes Simone da Silva Ribeiro
Published: September 2023

A temática abordada na presente pesquisa diz respeito à criminalização do ativismo feminista, utilizando como forma de impedimento das manifestações a violência institucional com o objetivo de amedrontar essas mulheres para fora desses espaços. Esses instrumentos são usados de forma a punir as feministas, ocorrendo de uma forma mais severa do que quando se trata de ativistas homens, sendo assim, há uma forma de repressão mais severa e presente quando trata-se de mulheres participando de movimentos na luta pelos seus direitos. Trata-se de uma pesquisa bibliográfica que conta com um levantamento bibliográfico, contando com livros e artigos científicos pertencentes a área de conhecimento social, acerca das temáticas que envolvem a criminalização das ativistas feministas, dos movimentos sociais em si e acerca do próprio feminismo em suas múltiplas formas. Conseguinte, a partir dos conceitos verificados, formula-se prognósticos demonstrando o elo entre a criminalização, e outras formas de repressão, do ativismo feminista com a clara insatisfação da sociedade perante ao feminismo em sua forma geral. Em paralelo, elabora-se uma base de dados com as informações básicas para sua identificação e outros elementos essenciais, como o coletivo o qual participa e qual seu cargo dentro dele, o tipo de violência sofrida e durante qual período ocorreu. Por fim, com todo material recolhido, apresenta-se quais fatos, que inicialmente eram meras hipóteses, têm respaldo nos autores escolhidos
AS DISPUTAS DISCURSIVAS ACERCA DAS RELAÇÕES RACIAIS NO BRASIL E SEUS EFEITOS NOS LIVROS DIDÁTICOS DE SOCIOLOGIA
Authors: Wermelinger Vitoria , Grosso Laura Mendes
Published: September 2023

Temos como finalidade discutir como o processo de racialização do sujeito negro no Brasil tem sido explicado por meio dos discursos de pacificação, democracia e harmonia racial. Afim de evidenciar a existência de uma disputa narrativa, trazemos enquanto contraponto, as análises do movimento negro brasileiro, especialmente, algumas das contribuições de Luiz Gama, Lima Barreto, Virgínia Bicudo e Abdias Nascimento, isto é, intelectuais negros (as) do final do século XIX e XX. Analisamos, então, quais são os efeitos e implicações destas narrativas nos livros didáticos de sociologia, destacando principalmente, como o debate das relações raciais são abordadas nos mesmos, visto que existe um silenciamento dos(as) intelectuais negros(as) e suas teses. A partir de uma revisão bibliográfica e uma análise documental, foi possível observar que os materiais didáticos em questão carecem de uma abordagem mais sólida a respeito da história e atuação do movimento negro brasileiro na agenda política, apresentando um discurso superficial sobre o racismo, tendo como fio condutor do debate, seja apresentando ou criticando, a teoria da democracia racial, formulada por Gilberto Freyre.
EMPRESÁRIOS NO CONSELHO DA CIDADE DE JOINVILLE: PERFIL E PARTICIPAÇÃO
Authors: Bergamaschi Pedro Lenhagui
Published: September 2023

O propósito deste estudo reside na investigação do perfil e atuação dos empresários que ocupam cadeiras de conselheiros no Conselho de Desenvolvimento Sustentável da cidade de Joinville (SC), também conhecido como Conselho da Cidade. Trata-se de uma instituição participativa de gestão do planejamento urbano, que tem como característica a eleição de cidadãos de diferentes segmentos para auxiliar na discussão de políticas públicas. Ainda que não seja uma entidade deliberativa, a participação dos empresários sugere que estes valorizam este espaço de gestão democrática. Foram coletados dados sociográficos dos conselheiros, considerando variáveis ocupacionais e de atuação no conselho ao longo de dois mandatos (2017-2022). O estudo identificou a predominância de empresários do ramo de construção civil e de corretagem de imóveis, além da presença de empresários noutros segmentos do conselho (como ONG’s e entidades acadêmicas), eleitos por entes que são próximas a outras representações empresariais. Estes achados sugerem a possibilidade de ampliação do poder de voto do empresariado para além do desenho institucional pretendido, sugerindo que este elemento pode ser objeto de atenção para o desenvolvimento e avaliação de políticas públicas neste campo. Outras abordagens metodológicas podem contribuir para uma compreensão mais aprofundada do fenômeno.
A FORMAÇÃO DA AGENDA GOVERNAMENTAL CLIMÁTICA EM CURITIBA, PARANÁ-BRASIL
Authors: Teixeira Rylanneive Leonardo Pontes , Soares Dias Eric Mateus , Pessoa Zoraide Souza
Published: September 2023

O objetivo deste artigo é analisar como a problemática das mudanças climáticas foi incorporada na agenda governamental de Curitiba e se tornou em uma política pública municipal. Para tanto, ancorando-se em uma metodologia qualitativa, este artigo desenvolveu um estudo de caso de Curitiba no que se refere à formação de sua agenda governamental climática, utilizando o modelo de Múltiplos Fluxos, de Kingdon, como perspectiva teórico-analítica. Como instrumento de coleta dos dados, foi empregado o levantamento de referenciais bibliográficos e de outros dados secundários. A partir da metodologia empreendida, os resultados do artigo apontam que, em Curitiba, o tema das mudanças climáticas se transforma de uma questão em um problema público quando os indicadores socioambientais locais evidenciam sua relevância como um problema dessa natureza; mas, sobretudo, quando os formuladores de políticas o enquadram como passível de políticas públicas (fluxo de problemas). A política municipal de mudanças climáticas de Curitiba, de 2020, foi resultante de ações locais da cidade em resposta à problemática. Essa trajetória teve início, mais precisamente, em 2009, a partir do Fórum Curitiba sobre Mudanças Climáticas (fluxo de soluções). Desde então, o fluxo político tem favorecido alterações na agenda governamental de Curitiba para abordar a questão climática de forma mais incisiva, com forte interferência de atores políticos e governamentais locais, aderindo a parcerias e convênios nacionais e internacionais de enfrentamento das mudanças climáticas, talvez até como uma estratégia para alocação de recursos para outros setores.
Identidade e Meio Ambiente nas canções do grupo ribeirinho Minhas Raízes do Distrito de Nazaré (Porto Velho-RO)
Authors: Lima Mathêus Sampaio da Silva
Published: September 2023

Esta pesquisa tem como objetivo analisar as canções do grupo Minha Raízes, oriundo de populações tradicionais do Baixo Madeira especificamente da comunidade de Nazaré orientado por pensadores como Adorno (2017) e Cunha (2009). Assim se fez uma coleta de dados por meio de entrevistas com os membros do grupo Minha Raízes, se transcreveu todas as canções dos álbuns investigados analisando a partir dos eixos de identidade e meio ambiente. Dando o caráter qualitativo desta pesquisa. Os dados encontrados e analisados demonstram que as canções são representações da comunidade, apresentando questões como as tensões entre cosmologias, a identidade ribeirinha, comensalidade, práticas de lazer e as relações entre humanidade e natureza localizadas na sociedade da capital
OLHARES SOBRE A EXPANSÃO DAS ENERGIAS RENOVÁVEIS NO RIO GRANDE DO NORTE: ENTRE CONFLITOS, CONTROVÉRSIAS E POSSIBILIDADES
Authors: Dias Eric Mateus Soares , Teixeira Rylanneive Leonardo Pontes , Pessoa Zoraide Souza
Published: September 2023

Este artigo busca compreender como as energias renováveis emergentes contribuem para a sustentabilidade global ao mesmo tempo em que geram impactos e conflitos socioambientais locais, analisando discursos dos atores envolvidos na defesa ou não do atual modelo de implementação dessas energias no Rio Grande do Norte (RN). Metodologicamente, o artigo se utilizou de uma metodologia com abordagem qualitativa, realizando um estudo de caso do RN a partir de discursos de atores ligados aos mais diversos setores de energias renováveis emergentes no estado, de modo a analisar, em geral, as questões de sustentabilidade global e de impactos e conflitos socioambientais locais gerados por essas energias. Como instrumento de coleta dos dados, foi empregado o levantamento bibliográfico e de outros dados secundários, sendo analisados através da análise de conteúdo. A partir dos dados obtidos, os resultados deste artigo consideram que as energias renováveis emergentes são fontes que corroboram na efetivação da sustentabilidade global quando subsidiam na transição energética, na descarbonização e no enfrentamento das mudanças climáticas. No entanto, a partir do caso do RN, é possível observar como as energias renováveis emergentes são produtoras de insustentabilidade no nível local, gerando impactos e conflitos aos territórios e suas populações. Muito embora, este não seja o discurso, sobretudo, do governo estadual do RN e seus representantes, bem como dos atores ligados ao setor privado, os quais defendem que são tais energias são renováveis, limpas, sustentáveis, e geradoras de desenvolvimento regional e local.
TWO MEMBERS OF THE EDITORIAL BOARD RECEIVE AWARDS FROM THE INTERNATIONAL CENTRE FOR HEAT AND MASS TRANSFER (ICHMT)
Authors: Chiu Wilson K. S. , Orlande Helcio R. B.
Published: September 2023

Renato Machado Cotta receives the 2022 Luikov medal and Leonid A. Dombrovsky receives the 2022 Fellowship Award.
Effects of storage temperature on viability and virulence of entomopathogenic nematodes Heterorhabditis bacteriophora Poinar, 1976 (Rhabditida: Heterorhabditidae), Steinernema carpocapsae Weiser, 1955 and Steinernema feltiae Filipjev, 1934 (Rhabditida: Steinernematidae)
Authors: BÜTÜNER Alperen Kaan , İLKTAN Merve , SUSURLUK Alper
Published: September 2023

Entomopathogenic nematodes (EPN) are a widely used biological control agent. The aim of the study was to detect efficacy and mortalities of some EPN stored at different temperatures and periods. Three EPN species were used in the study. They were Heterorhabditis bacteriophora Poinar, 1976 (Rhabditida: Heterorhabditidae) HBH hybrid strain, Steinernema carpocapsae Weiser, 1955 TUR-S4 isolate and Steinernema feltiae Weiser, 1955 (Rhabditida: Steinernematidae) TUR-S3 isolate. The species were kept at 4, 15, 25 and 35°C for 7, 14 and 21 days. Subsequently, these species were applied at a dose of 15 Infective juveniles on Tenebrio molitor L., 1758 (Coleoptera: Tenebrionidae) larvae. The study was carried out in laboratory conditions in 2023. As a result, HBH and TUR-S4 kept at 25°C for 14 days and TUR-S3 for 21 days showed the highest virulence as 93.33%. Mortality rates of the EPN species kept at the specified temperatures were also determined. The results have showed that the highest mortality rates for the HBH, TUR-S4 and TUR-S3 isolates were 11.96% on the 14th day at 35°C, 19.81% on the 21st day at 25°C and 7.39% on the 21st day at 35°C, respectively. This study is an important step in determining suitable temperature conditions for storing and transporting EPN.
Plasmid Construction and Gibson cloning v1
Authors: Adriaenssens Elias
Published: September 2023

This protocol describes plasmid construction.
Purification of MBP-NAP1 v1
Authors: Adriaenssens Elias
Published: September 2023

This protocol describes purification of MBP-TEV-NAP1 protein.
Mitochondrial isolation protocol v1
Authors: Adriaenssens Elias
Published: September 2023

This protocol describes how to isolate crude mitochondrial fractions from HeLa cells.
Evaluation of the maintenance system readiness using the semi-Markov model taking into account hidden factors
Authors: Kozłowski Edward , Borucka Anna , Oleszczuk Piotr , Jałowiec Tomasz
Published: September 2023

Modelling the time that the system remains in a given state using classical distributions is not always possible. In many cases, empirical distributions are multimodal due to the influence of external, hidden factors and the selection of the best classical distributions may lead to erroneous results. In the article the method of diagnosis of influence of hidden factors into sojourn time of semi-Markov models was presented. In order to capture hidden factors, the authors proposed to model the distributions of the sojourn time with a mixture of distributions, which is a significant novelty in relation to the studies presented in the literature. Hidden factors directly affect the reliability of technical systems. Detecting the existence of these factors enables more accurate modeling of system readiness. Paying attention to irregularities caused by hidden factors makes it possible to reduce system maintenance costs. Such a system model provides complete information and enables a reliable assessment of the system readiness and maintenance.
Ядерные метаморфозы
Authors: Арбатов Алексей
Published: September 2023

В международном сообществе цивилизованных политических деятелей и стратегических экспертов общепринята сакраментальная сентенция о том, что “в ядерной войне не может быть победителей, и она никогда не должна быть развязана”, как и о том, что “ядерные вооружения – пока они продолжают существовать – должны служить сдерживанию агрессии и предотвращению войны”. Однако эти благие принципы легче провозглашать, чем претворять в практическую политику. Хотя создание всех ядерных вооружений во всех странах обосновывается задачами сдерживания войны, в то же время все эти средства предназначены для реального ведения ядерной войны, являясь материальной основой доктрин ядерного сдерживания. В зависимости от сценариев применения ядерного оружия, под влиянием военно-технического развития и в обстановке острых международных конфликтов эти доктрины претерпевают устрашающие метаморфозы и превращаются в свою противоположность – планы и практические варианты развязывания ядерной войны. В последнее время это проявляется в российском стратегическом дискурсе о способах скорого и успешного завершения военной спецоперации на Украине. Подобные инициативы создают для России угрозу национального самоубийства. Мирному урегулированию украинского конфликта нет приемлемой альтернативы, а разногласия по его условиям не стоят риска ядерного апокалипсиса. Реально разграничить потенциалы для ядерного сдерживания и арсеналы для ведения ядерной войны возможно только путем договоров о сокращении и ограничении ядерных вооружений. Ядерные силы и системы оружия, охваченные такими соглашениями, служат целям сдерживания, а остающиеся вне контрольно-ограничительных мер – воплощают в себе угрозу развязывания ядерной войны.
Понятие «инновации» как политический инструмент: от линейной инновационной модели к «треугольнику знаний»
Authors: Коннов Владимир , Талагаева Дарья
Published: September 2023

В статье рассматривается история политического продвижения понятия “инновации”. Для изучения изменений в содержании данного термина применяются два подхода – интеллектуальной истории в версии Кембриджской школы и международной политической экономии. Первый подход нацелен на установление роли этого понятия в продвижении интеллектуальных интересов ученых, развивавших теорию инноваций, второй – на определение роли понятия в контексте взаимного влияния политики и экономики в международных отношениях. Исследование выполнено в три этапа. Первый – изучение истории вопроса и попытка интерпретации понятия “инновации” в современном ключе. Второй – обзор эволюции этого понятия в обороте ОЭСР, которая сыграла определяющую роль в создании инновационной политики как особого направления государственного регулирования. Проведенный обзор позволяет наблюдать, как продвижение понятия “инновации” разворачивалось в контексте двух линий соперничества: между экономическим и научным подразделениями организации и между экономистами кейнсианской и неолиберальной школ. Непосредственный же разбор документов ОЭСР по проблемам научной и инновационной политики показывает, как понятие “инновации” расширялось, отражая поиск странами ОЭСР возможностей выйти на устойчивые показатели экономического роста. Наконец, третий этап исследования – анализ использования понятия “инновации” в концепции “треугольника знаний”, который демонстрирует, что начиная с 1990-х годов данное понятие способствовало продвижению части университетских сообществ, связанной общими интересами с транснациональными корпорациями. В политэкономическом же смысле современное понятие “инновации” работает в пользу группы корпораций, составляющих ядро экономики знаний и нацеленной на расширение транснационального экономического поля, к которой можно условно отнести и ведущие мировые университеты.
Традиция и инновация как концепты политической науки и ориентиры политики развития: диалектика совместимости
Authors: Семененко Ирина
Published: September 2023

В статье рассматриваются подходы к концептуальному анализу социально-политических изменений, поставлен вопрос о содержании понятия “общественное развитие” и о трактовке “политики развития” как его управляемого измерения. В современном научном дискурсе ощутим дефицит адекватных терминов и емких языковых форм для описания критериев, принципов и механизмов общественного развития; в уточнении нуждается и сама исследовательская парадигма. В рамках характеризующих общественное развитие теоретических подходов можно условно выделить дихотомию “традиций” и “инноваций”, которая отражается в преемственности и дискретности социально-политической динамики. При этом в политико-управленческих практиках, реализуемых от имени государства, нередко абсолютизируется та или иная составляющая такой дихотомии. В статье рассматривается вопрос о принципиальной возможности позитивной совместимости традиций и инноваций в повестке дня публичной политики в современных обществах, глубоко разделенных по ценностным и социокультурным основаниям, о путях и ограничениях такого совмещения. Обосновано, что эффективность политики развития зависит от взаимного усиления традиций и инноваций и их ситуативных сочетаний. Опираясь на анализ дискурсов и нарративов о развитии и на оценки опыта позитивного совмещения традиций и инноваций в деятельности субъектов публичной политики на локальном уровне, автор отмечает настоятельную необходимость в развитии культуры диалога между элитными и массовыми группами и внутри этих групп по вопросам разработки и реализации политики развития. Аргументирована потребность в нахождении в публичной политике возможностей обеспечить взаимодействие этих механизмов самоорганизации общества, удовлетворяющих запрос на ответственное развитие. В основе такого подхода – усвоение традиционных ценностей в рамках социального опыта инновационной, ориентированной на социальное творчество личности.
Традиции и инновации в политике развития сельских территорий России: потенциал казачества
Authors: Морозова Елена , Мирошниченко Ирина
Published: September 2023

Целью статьи является обоснование роли взаимовлияния традиций и инноваций в развитии сельских территорий. На примере казачества авторы рассматривают практики успешной адаптации традиций к реалиям современности и наращивания на ее основе экономического, социального, политического и символического капитала казачества. Методология исследования выстраивается на использовании концепта ответственного развития, принципов политической субъектности социальных групп, модели сложносоставной идентичности. В качестве эмпирической базы использовались официальные документы, данные ведущих социологических центров, материалы проведенных авторами экспертных сессий. Проанализировав практики казачьей экономики и казачьего образования, авторы выделили механизмы успешной адаптации традиций и продуцирования инноваций. Казачество складывалось в зоне фронтира, контакта различных социокультурных практик, и это сыграло важную роль в формировании его идентичности, поддерживая открытость инновациям. Ценности казачества актуализируются не только на когнитивном и эмоциональном, но и на инструментальном уровне, воплощаясь в моделях поведения. “Ядро” привлекательности казачества для российских граждан составляют традиции, адаптированные к современным реалиям и вызовам. Инклюзивная идентичность казачества – один из ключевых факторов строительства дееспособных местных сообществ – превращается в значимый нематериальный ресурс развития сельских территорий. Сочетание традиций и инноваций усиливает конструктивный потенциал социальных субъектов, выступает не только фактором развития, но и защитным механизмом в условиях рисков и неопределенности.
Древнекитайская философия на службе внешней политики КНР: директивы и трактовки
Authors: Дикарев Андрей , Фань Сюэсун
Published: September 2023

После прихода к власти в 2012 г. Си Цзиньпина правительство КНР стало выстраивать стратегию международных отношений нового типа, истоками которой выступили положения конфуцианства и других древних китайских философских школ, а также взгляды Си Цзиньпина на международные отношения. В статье проанализированы некоторые конкретные примеры древних философских концепций, поставленных в Китае на службу современности. Таковы “китайская мечта”, “правильное воззрение на справедливость и выгоду” и “Сообщество единой судьбы человечества”. По мнению китайского руководства и ведущих китайских политологов, общественно-политические идеи, восходящие к древней китайской культуре, могут открыть миру новую, альтернативную западной стратегию модернизации и развития.
Политические инновации: очевидные смыслы и неочевидность реальности
Authors: Соловьев Александр
Published: September 2023

Перемены и обновление общественных порядков и институтов всегда проблематизируют вопрос о сути и характере политических инноваций. Однако традиционное толкование этих трансформаций как прорывных преобразований, относящихся к технологическим изменениям и благоустройству среды человеческой жизнедеятельности, не всегда артикулирует их значение как инструментов изменения базовых параметров политической системы и баланса политических сил. Данные проекты, будучи исключительным продуктом политических элит, содержат в себе все преимущества и издержки внутриэлитной конкуренции, являющейся триггером существенных изменений в поле политики и инструментом позиционирования каждого сегмента правящего слоя в системе власти. Наиболее ярко вес и влияние политических инноваций, поддерживаемых статусными и неформальными сегментами правящей элиты, проявляется в зоне принятия государственных решений, цели которых определяют характер распределения и перераспределения общественных благ и ценностей. В то же время недекларируемые установки элитных группировок и их информационная защита, сочетающаяся с активным использованием латентных механизмов политического проектирования, не позволяют обществу ни адекватно оценивать публичные действия, ни осознавать подлинные замыслы властей предержащих. Возникающие в зоне принятия решений межинституциональные трения и конфликты не только предопределяют столкновение различных подходов и представлений элитных группировок, но и отражаются в противоречивых сигналах, посылаемых обществу, провоцируя в массовом сознании разрозненные и подчас не имеющие ничего общего с реальностью оценки и представления о процессах, идущих в политической сфере этого общества. Такой тип продвижения инновационных проектов, обусловливая когнитивные подвижки и кризисы массового сознания, в конечном счете сказывается на содержании идентификационных моделей, доминирующих среди населения. Прежде всего это отражается на формировании у граждан генерализированного образа Отечества, являющегося единой платформой отношения общества к предлагаемым идеям и планам. В то время как соответствующее общественным интересам создание надежной системы общегражданской идентификации предполагает особый стиль деятельности государства, поддержание властями атмосферы свободного поиска гражданами своих политических солидарностей, диалогических форматов коммуникации власти и населения, а также поощрение межкультурного общения.
Территориальное государство и сложное общество: императив коэволюции в пространстве политики
Authors: Лапкин Владимир
Published: September 2023

В статье делается попытка реконструировать комплекс представлений, связывающих в политическом дискурсе современное сложноорганизованное общество с олицетворяющим его в сфере политики территориальным государством. Актуализация потребности в более углубленном изучении этой взаимосвязи обусловлена кризисными тенденциями современной политической динамики, включая кризис текущей версии глобализации. Но также и тем стремительно растущим давлением, которое на территориальные сообщества и политии оказывают макросообщества иной надгосударственной и/или сетевой природы, демонтирующие прежние принципы организации миропорядка и тем самым бросающие вызов принципу территориальной государственности и самому существованию территориально организованных сообществ как таковых. Автор проводит анализ симбиотической связи современного общества и территориального государства, а также эволюционных перспектив обоих ее участников – как по отдельности, так и в коэволюционном сопряжении. Методологическую основу исследования составляет сочетание методов анализа политического дискурса, институционального, концептуального и структурно-функционального анализа, методов идентитарных исследований и ряда других. Ключевыми концептами анализа, осуществляемого в статье, являются сложное общество и территориальное государство как его политическая форма, а также провалы управления, войны за переучреждение государства и экстратерриториальные сообщества. Именно с возрастанием роли последних связан тренд перехода от локальных войн за переучреждение государства к глобальному открытому противостоянию с перспективой переучреждения всего политического миропорядка, при неочевидности в настоящий момент тех новых институциональных форм, в которые он будет облекаться.
A multidisciplinary approach with immunotherapies for advanced hepatocellular carcinoma
Authors: Lee Yu Rim
Published: September 2023

Hepatocellular carcinoma (HCC) is a highly aggressive disease that is usually diagnosed at an advanced stage. Advanced HCC has limited treatment options and often has a poor prognosis. For the past decade, tyrosine kinase inhibitors have been the only treatments approved for advanced HCC that have shown overall survival (OS) benefits; however, but their clinical efficacy has been limited. Recent trials have demonstrated promising advancements in survival outcomes through immunotherapy-based treatments, such as combinations of immune checkpoint inhibitors (ICIs) with other ICIs, antiangiogenic drugs, and locoregional therapies. The atezolizumab-bevacizumab and durvalumab-tremelimumab (STRIDE) regimen has significantly improved survival rates as a first-line treatment and has become the new standard of care. Therefore, combined treatments for advanced HCC can result in better treatment outcomes owing to their synergistic effects, which requires a multidisciplinary approach. Ongoing studies are examining other therapeutic innovations that can improve disease control and OS rates. Despite improvements in the treatment of advanced HCC, further studies on the optimal treatment selection and sequences, biomarker identification, combination approaches with other therapies, and development of novel immunotherapy agents are required. This review presents the current treatment options and clinical data of the ICI-based combination immunotherapies for advanced HCC from a multidisciplinary perspective.
Acid Rain and Seed Germination: A Predictive Model Using ML-based CART Algorithm
Authors: Arora Vasundhara , Singh Bikram Jit , Bithel Navneet , Mukherjee Tapan Kumar , Upadhyay Sushil Kumar , Sehgal Rippin , Singh Raj
Published: September 2023

The impact of acid rain on the germination of seeds is a significant concern in agricultural and environmental studies. Acid rain, characterized by elevated acidity levels due to pollutants like sulfur dioxide and nitrogen oxides, can adversely affect the germination process of various plant species. The objective of this study was to evaluate the impact of simulated acid rain (SAR) on the germination of Brinjal (Solanum melongena Linn.) and Cowpea (Vigna unguiculata ssp. cylindrica L. Walpers) crops. The experiments were conducted using eight plastic trays of approximately 25 cm. x 30 cm dimensions. Four trays were used for experiments with brinjal seeds (Set I), while the other four were used for cowpea seeds (Set II). One tray from each set was used as positive control and treated with normal pH 5.6, while the other three trays from each batch were treated with SAR solutions of pH 4.5, 3.5, and 2.5. Brinjal seed germination percentage and seed vigor were inferior to Cowpea seeds. The seeds treated with SAR (pH 4.5, 3.5, and 2.5) showed hindered seed germination. Furthermore, a more significant inhibitory effect was observed at lower pH values. The mean germination percentage of seeds was highest for standard SAR (pH 5.6) in the case of Brinjal seeds, while it was recorded lowest for Cowpea seeds. The results indicate that plants do not respond uniformly to SAR. To investigate the behavior of the simulated acid rain data, a Machine Learning-based Decision Tree Algorithm was employed to identify and optimize conditions. Cowpea was predicted to get 95% seed germination, whereas brinjal would only be 64% in acid rain of pH value 5.05 for 36 hours. In conclusion, utilizing a Machine Learning-based CART algorithm has provided valuable insights into predicting the germination behavior of seeds under the influence of acid rain.
Exploratory Data Analysis and Visualization for Business Analytics
Authors: Deming Chunhua , Dekkati Sreekanth , Desamsetti Harshith
Published: September 2023

The advantages of doing exploratory data analysis have been discussed in this article. We have gone through the typical data preprocessing procedures to understand the data and prepare it for modeling. In this research, we intend to become familiar with the most extensively utilized predictive modeling techniques and the fundamental principles underlying these techniques. Developing statistical or machine-learning models to generate predictions based on data is an example of predictive modeling, which is creating these models. We will use one typical example to make our research more tangible and demonstrate how the performance of various models varies when applied to the same data set. Exploratory data analysis will be covered in depth here, so prepare for that! In the following, we will discuss comprehending and validating the data.
Front-End Development in React: An Overview
Authors: Chen Songtao , Thaduri Upendar Rao , Ballamudi Venkata Koteswara Rao
Published: September 2023

In front-end development, the function that react.js plays is becoming increasingly important, providing developers with new options to create new applications. This article discusses how react.js assists in constructing user interfaces and the benefits it offers in building front-ends. According to the survey carried out by Web Technology Surveys, react.js is utilized by a significant percentage of all websites today. We will not exaggerate the situation if we declare that React.JS is used everywhere. When it comes to websites, new audiences have various interests. This article discusses critical aspects of the framework, including its advantages over competing frameworks, how it works, and its architecture.
Underexploited benefits of microbial secondary metabolites: Major challenges a review
Authors: Atreya Suchita
Published: September 2023

Secondary metabolites (SMs) are naturally occurring compounds produced mostly by bacteria, fungus, and plants. They are low-molecular-weight compounds with a wide range of chemical structures and biological functions. In contrast to main metabolites such as lipids, amino acids, carbohydrates, and nucleic acids, the name secondary metabolite comes from the discovery that their creation is not required for organism growth and reproduction. SMs, on the other hand, are far from secondary, and the term "specialised metabolites" is being used to characterise them. Organic chemists, molecular biologists, and bioinformaticians are all working on SMs manufacturing these days.
Antibiotic resistance pattern of aerobic bacterial isolates from patients with skin and soft tissue infections in Karaikal
Authors: Swarna SR , Vetreivellan H , Prabakar G , Manobalan K , Bharathi T
Published: September 2023

Skin and Soft Tissue Infections (SSTIs) are considered as non-fatal burden with significant morbidity and disability. The important challenge of severe SSTIs is choosing a drug for empirical treatment. From this region, only limited local antibiogram data is available.

To determine the frequency of different aerobic bacteria isolated from patients with SSTIs attending dermatology and surgery departments of GH, Karaikal and to study the antibiotic resistance pattern of the isolates.

This is a prospective, cross-sectional study with 100 samples. Standard protocol was followed for collection, processing, identification and antibiotic susceptibility testing. All isolates of and were screened for methicillin resistance and subsequently subjected to Oxacillin E-strip and Vancomycin E-strip to know the minimum inhibitory concentration (MIC) value. Isolates of Gram negative bacilli resistant to one or more carbapenems were tested for carbapenemase production using Modified Carbapenem Inactivation Method (MCIM) and multi drug resistant (MDR) organisms were identified.

Most effective antibiotic for methicillin sensitive (MSSA) are Clindamycin (82.75%), Gentamicin (80.95%) and Cotrimoxazole (75%). The methicillin resistant (MRSA) incidence is 6.89% (2/29). Around 66.67% (4/6) of was Cefoxitin resistant. The carbapenem resistance was found to be 13.88% (5/36). Around 43.13% (22/51) Gram negative bacilli were MDR.

The presence of MRSA and carbapenemase producing Gram negative bacilli are worrisome. Further, routine surveillance is needed to monitor the trends in antibiotic resistant pattern. However, this data paves way for judicious use of antibiotics for treatment and to prevent development of resistance in future.
Antimicrobial resistance among common clinical isolates from Wayanad district
Authors: B J Deepthy , A Athira , H Champa , S Maya , Hynse Aimy
Published: September 2023

: The emerging multi-drug resistant variants in different clinical isolates is leading to increased morbidity and mortality, due failure in treatment. The paucity of an accurate data of antimicrobial resistance from different geographical areas is a major setback to its control and management. The aim of this study was to analyse the occurrence of drug resistant organisms from different clinical samples in the district of Wayanad, and also to determine the most prevalent and emerging bacterial pathogens among them.

: A seven-month retrospective study of different bacterial isolates from various clinical samples was conducted in a tertiary care hospital in Wayanad district. Clinical samples taken for the study included urine, pus, sputum and blood.

: Data from 2125 clinical samples were studied, in which 661 were urine samples, 910 were pus samples, 225 were blood samples and 339 were sputum samples. The predominant bacteria identified from urine sample was among which the prevalence of extended spectrum beta lactamase (ESBL) producing was 40.61%, and the metalobetalactamase (MBL) producers 3.45%. was the predominant bacteria in the pus samples, in which Methicillin resistant (MRSA) was found to be 3.92%. was the most predominant bacteria in the blood samples, in which ESBL producing was noted as 3.57%. Klebsiella species were the predominant bacteria in the sputum samples, in which ESBL producing was 16.79% and MBL producers were 3.82%.

: The study helped to identify the most predominant antibiotic resistant strains from each of the clinical samples in a resource limited setting like Wayanad. Similar studies would help in successfully formulating treatment strategies against bacterial infections, thereby reducing morbidity and mortality in patients.
A retrospective investigation of Candida spp. and its antifungal susceptibility profile in cancer patients at a South Indian tertiary care hospital
Authors: Vijayakumar Varalakshmi , Emelda Jennifer , Radhakrishnan Venkataraman , Subramani Saraswathi
Published: September 2023

Among the most frequently recognized pathogenic fungi, . from Clinical samples plays a vital role. In recent decades, poor antifungal therapy usage critically in immunocompromised patients has led to antifungal drug resistance among . Hence, expeditious and dependable species identification is crucial for the effective implantation of treatment strategies and the management of diseases.

The purpose of the study was to look at the presence of in various Clinical samples taken from cancer patients who are being treated at a tertiary care hospital in South India. The primary objective of this investigation is to ascertain the susceptibility patterns shown by antifungal drugs. This retrospective investigation was undertaken between January 2022 to April 2023.

The isolates were subjected to antifungal susceptibility (AFST) by both Conventional (disc diffusion assay) and Automated methods (VITEK-2 compact - AST YSO1). The susceptibility pattern was recorded against antifungal agents like Fluconazole (FLU), Voriconazole (VOR), Amphotericin B (AMB), and Caspofungin. . was identified by conventional method (Chrome ID) as per standard laboratory protocols and by an automated method using MALDI – TOF.

Among 215 samples received from cancer patients suggestive of Candidiasis, albicans (64.6%) was the predominant isolate, and the lowest one was (2.25%). Male patients had a higher prevalence of (55.8%). Similarly, the prevalence was higher in patients over 60, with male patients having an incidence of 38.3% and female patients having 23%. By disk diffusion assay and showed 100% sensitivity to all antifungals used in this study.

We conclude that the disc diffusion assay is a more cost-effective, user-friendly, and effective screening test than the VITEK 2, and it has the potential to be used as a workable method for Antifungal susceptibility test. The use of Chrome ID for identification of . is cost-effective and reliable. However, MALDI TOF has the advantage of rapidity, providing correct findings promptly. The timely delivery of diagnostic reports facilitates early diagnosis of patients. Therefore, it is recommended in this research to use MALDI TOF for the identification of . and the disc diffusion technique for antifungal susceptibility testing (AFST).
Epidemiological trends of COVID-19 pandemic during first and second waves: A comparative study in east Godavari district, Andhra Pradesh, India
Authors: Murty D Satyanarayana , Babu BV Suresh , Rani A Durga , Rajyalakshmi G
Published: September 2023

From Wuhan, China, the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection that caused the coronavirus disease 2019 (COVID-19) spread quickly to other countries. India experienced its first wave of COVID-19 infection between March 2020 to February 2021 with the peak in August 2020.The second wave started in March 2021 and continued for few months till November 2021.

This study has been conducted to describe the epidemiological trends based on laboratory data at East Godavari district, Andhra Pradesh, India.

The study was performed between March 2020 to November 2021at a tertiary care centre in East Godavari Dist., AP. Samples (Throat/ Nasal/ Nasopharyngeal swabs) were received from the Government hospitals in East Godavari district for Covid-19 Real time PCR.

A total number of 5,00,869 and 8,75,808 samples were tested using rRT-PCR, and 39,626 (7.9%) and 98,656 (11.2%) were positive during first and second waves respectively. In the first wave the highest positivity rate was observed in the month of August (26.8%) whereas in Second Wave it was observed in the month of May (36.6%). In the both the waves highest positivity was observed in the age group 70-79 years (first wave 11.1% and second wave 16.3%). In both the waves the positivity rate of males was higher than females. Among symptomatic cases, the positivity rate was in the first wave 8.6% whereas in second 19.1% was observed.

The overall, higher positivity rate was observed in the second wave when compared to first wave. Also we observed a noticeable difference between the 1 and 2waves in terms of positivity percentage among symptomatic cases.
Antimicrobial activity of Lactobacillus acidophilus bacteriocin against clinical isolates
Authors: Al-Haddad Ahmed Mohammed , Al-Haik Wedad Mohammed , Matran Yasser Mansour , Bawazir Ibrahim Mohammed
Published: September 2023

Lactic acid bacteria serve as important human probiotics, as they can produce bacteriocins from different dairy sources, and the antimicrobial activity of their bacteriocins have been documented in the scientific field. This study aimed to assess the antimicrobial activities of bacteriocin obtained from different dairy sources.

An experimental analytical design was used to isolate species on de Man, Rogosa and Sharpe Media, and identify them phenotypically and evaluated their bacteriocin's antimicrobial activity against four clinical isolates. SPSS Version 22 was used for Statistical purposes.

A total of 14 isolates were verified from various sample sources. These included 6 isolates from camel's milk, 2 from goat's milk, 3 from local yogurt, and 3 from Omani yogurt. The supernatants of most isolates exhibited varying levels of antimicrobial activity during the investigation. Furthermore, the action of the bacteriocin was concentration dependent. The highest level of inhibition was 14 mm for Staphylococcus aureus, 12 mm for, 12 mm for and 10 mm for when using 100μl of raw bacteriocin. Moreover, the correlation between bacteriocin activity, temperatures, and incubation times was found to be irreversible.

The study reveals inherent antibacterial traits in species from local milk and milk products in Al-Shihr Town. Specifically, variant, synthesizing bacteriocin, effectively suppressed the clinical isolates, showcasing their pathogen-fighting ability. These findings offer potential for developing efficient antimicrobial methods, utilizing bacteriocin as an antibiotic in food and medicine.
An interesting case of scrub typhus meningoencephalits
Authors: Gautam Swapnil , Agarwal Apurva , Vashisth Jay Mukesh
Published: September 2023

Rickettsial diseases are a re-emerging group of illnesses that are known to show a good response to treatment if diagnosed in time. Here we report a case of Scrub Typhus-related Meningoencephalitis in a young gentleman and the importance of high clinical suspicion with early empirical treatment in patients with consistent epidemiological context.
A case study of rhino orbito cerebral Mucormycosis (ROCM) in a diabetic patient reported from a multispeciality hospital in Tamil Nadu
Authors: John V Shiney , Kathirvelu Shakthesh , S Varun , Srirangaramasamy Jamunarani , Babu Joseph Jensingh
Published: September 2023

ROCM is the most common type of Mucormycosis and it can rapidly spread from the paranasal sinuses to orbit and brain which can be fatal in most patients. Diabetes mellitus is the most common risk factor in India. As invasive fungal diseases present with nonspecific clinical features, increasing awareness and education among clinicians about this deadly enemy is very crucial for early diagnosis and prompt initiation of appropriate therapy. We are reporting a case study on ROCM in a Diabetic patient caused by species along with a short review on the taxonomy, risk factors, pathogenesis, clinical forms, diagnosis and management of mucormycosis. We hope that this will help in expanding awareness among medical community about mucormycosis which is a lethal opponent of patients with Diabetes Mellitus.
Surgical wound infection by Pluralibacter gergoviae in a diabetic patient
Authors: Prabhala Srujana , Sundaresan Aarthi , Varaiya Ami , Chitkara Garvit
Published: September 2023

is reported to cause infections in immunocompromised patients and also nosocomial outbreaks. This is a case of soft tissue infection in a diabetic patient who underwent a surgery on the left breast and a bilateral reduction mammoplasty following all preliminary investigations. Post operatively, she presented with the complaints of poor wound healing and a wound gap. Immunocompromised state, uncontrolled diabetes and topical application of cream or ointment during post-operative period could be risk factors for an infection by Little is known about this organism and its clinical significance. Hence documentation of such case scenarios is essential to gather more clinically relevant information.
A rare case of intracardiac hydatid cyst in the interventricular septum of the heart
Authors: Reddy R Sathish Kumar , Devi A Renuka , Swamy Laxmana
Published: September 2023

Hydatid disease, also known as cystic , occurs due to tapeworm. It is an endemic disease in certain livestock-raising countries. Cardiac involvement is seen rarely, in around 0.5% to 2% of patients with hydatid disease. Interventricular septum is involved in around 4% of cardiac cases. According to Yaman et al., cardiac is a rare condition with a prevalence ranging between 0.5 to 2 percent. Here we report a case of a hydatid cyst in the heart. A 57-year-old male patient came to Gowri Gopal hospital, Kurnool, Andhra Pradesh on 29 July 2023 with complaints of shortness of breath for 6 months. He also complained about pain in the chest region for 6 months.ECG findings include sinus tachycardia, probable left atrial enlargement, left ventricular hypertrophy, nonspecific T abnormalities and ST elevation. Chest X-ray PA View revealed left mild fibrosis. Echocardiography showed a hydatid cyst sized 3x2.8 cm., grade I diastolic dysfunction and trivial mitral regurgitation. The patient underwent surgical excision and mitral valve repair. He recovered and was discharged successfully. We conclude that surgical resection, washout of the cavity with saline solution, and albendazole treatment can produce excellent outcomes in interventricular cardiac hydatid cyst cases.