bluuebunny/crossref_metadata_2025 huggingface dataset:
An empirical study on management accountants’ roles and role perceptions: A German perspective
Authors: Rieg Robert , Ulrich Patrick , Finckh Carmen
Published: November 2022

The ongoing discussion on roles of management accountants (MAs) leads often to perceive the business partner (BP) role as the role of choice. Yet, many scholars and practitioners seem to assume that this role is clear to managers and MAs, that it makes sense for them and that all managers and MAs agree on it and implement it. Inconsistencies between actual roles, perceived, and expected roles might cause identity and role conflicts. However, we lack evidence of whether managers and MAs perceive, expect and act in the BP role and if tensions and conflicts might exist. This paper is based on a quantitative empirical study of a large German high-tech firm in 2019 whose top management decided to implement the BP role. We found several areas of tension in this role discussion and contribute to the literature on MAs’ roles with a more nuanced view of the interaction between managers and MAs regarding MAs’ roles. The study shows that there are mainly differences in business managers’ expectations of MAs to the role of the BP, which the MAs do not know exactly how to fulfill
Authentic Entrepreneurity and Global Entrepreneurship: A Case Study Research on Luxury Fashion Company, Simone
Authors:   Academy of Entrepreneurship, Cha Min-Seok
Published: November 2022

This study investigated a global fashion company with longitudinal two-staged in-depth case study research. Global luxury handbag stems from Aristocratic culture among European. Global luxury brand like Louis Vuitton, Buberry and others have roots in that region. Within dozens of years several global fashion brands such as DKNY, Michael Cors, Coach, and so on are launched in US. Behind the scenes, Simone Co., an entrepreneurial company takes the role of supportive partners. This company has first OEM order from a globally top-tier brand instead of European manufacturer. Since then, it has evolved to provide full package of services from design to delivery. The first entrepreneurial success story from Asia (Breaking the prejudice of ‘Asia discount’). The growth stages starts with the opening the window of opportunity. Authentic entrepreneurity can be stated as “Affordable Luxury in made in Asia.” Simone developed competence of design to be the first ODM in Asia. The vision of Brand Orchestra in Global Opera of Luxury Handbag with global brands continue to be realized with the lead customers and partners. Longevity with DKNY(since 1987), 11 years with LVMH (since 2000) are exceptional partnership. The deeper OCEAN of entrepreneurity was studied from the grounded theory approach to figure out 10 elements of entrepreneurity that linked with Entrepreneurial Orientation(EO) and actions: Innovation, risk taking, and proactive pursuit of opportunities. The global scale of success in fashion entrepreneurship are extraordinary for the sustainablity. The possibility in the sector is based on the combination of the three continental strength of entrepreneurity, and entrepreneurial orientation with innovation, proactiveness, and risk-taking. The value added are increasing with traditions, market, and the craftsmanship. There are some implications to the entrepreneurship scholars, educators, and practitioners in the field.
N-end Rule–Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage
Authors: Xu Jiesi , Liu Zhenglong , Zhang Jianxin , Chen Siyu , Wang Wei , Zhao Xuefan , Zhen Mei , Huang Xun
Published: November 2022

Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. The rate-limiting triglyceride hydrolase ATGL (desnutrin/PNPLA2) is critical for lipolysis. The control of ATGL transcription, localization, and activation has been intensively studied, while regulation of the protein stability of ATGL is much less explored. In this study, we showed that the protein stability of ATGL is regulated by the N-end rule in cultured cells and in mice. The N-end rule E3 ligases UBR1 and UBR2 reduce the level of ATGL and affect lipid storage. The N-end rule–resistant ATGL(F2A) mutant, in which the N-terminal phenylalanine (F) of ATGL is substituted by alanine (A), has increased protein stability and enhanced lipolysis activity. ATGLF2A/F2A knock-in mice are protected against high-fat diet (HFD)–induced obesity, hepatic steatosis, and insulin resistance. Hepatic knockdown of Ubr1 attenuates HFD-induced hepatic steatosis by enhancing the ATGL level. Finally, the protein levels of UBR1 and ATGL are negatively correlated in the adipose tissue of obese mice. Our study reveals N-end rule–mediated proteasomal regulation of ATGL, a finding that may potentially be beneficial for treatment of obesity.
An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
Authors: Derr Alan G. , Arowosegbe Adediwura , Satish Basanthi , Redick Sambra D. , Qaisar Natasha , Guo Zhiru , Vanderleeden Emma , Trombly Melanie I. , Baer Christina E. , Harlan David M. , Greiner Dale L. , Garber Manuel , Wang Jennifer P.
Published: November 2022

Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study temporal events in pancreatic islets in LEW.1WR1 rats, in which autoimmune diabetes can be induced with virus infection, by performing transcriptional analysis of islets harvested during the prediabetic period. Single-cell RNA-sequencing and differential expression analyses of islets from prediabetic rats reveal subsets of β- and α-cells under stress as evidenced by heightened expression, over time, of a transcriptional signature characterized by interferon-stimulated genes, chemokines including Cxcl10, major histocompatibility class I, and genes for the ubiquitin-proteasome system. Mononuclear phagocytes show increased expression of inflammatory markers. RNA-in situ hybridization of rat pancreatic tissue defines the spatial distribution of Cxcl10+ β- and α-cells and their association with CD8+ T cell infiltration, a hallmark of insulitis and islet destruction. Our studies define early islet transcriptional events during immune cell recruitment to islets and reveal spatial associations between stressed β- and α-cells and immune cells. Insights into such early processes can assist in the development of therapeutic and prevention strategies for T1D.
Investigations of process by-products by means of Schlieren imaging during the powder bed fusion of metals using a laser beam
Authors: Baehr Siegfried , Melzig Lukas , Bauer Dominik , Ammann Thomas , Zaeh Michael F.
Published: November 2022

To produce geometrically complex parts with good mechanical properties, various industries increasingly apply the powder bed fusion of metals using a laser beam. Sufficient control of this laser-based additive manufacturing process is necessary to achieve a reliable development as well as reproducible part properties. Besides adjusting the standard process parameters, such as the laser power or the scanning speed, the process gas is an important parameter that influences the part characteristics. In addition to the inertization of the atmosphere, process by-products can be removed during the manufacturing with a constant gas flow across the build plate. Typically, argon or nitrogen is applied. This study investigated the effects of various argon-helium mixtures in comparison to pure argon gas on the heat balance of process by-products during the processing of a high-strength aluminum alloy by means of Schlieren imaging. The method enables visualizations of the process by-products and is further capable of studying evaporation phenomena. For this purpose, a Schlieren imaging setup was designed and installed in an AconityMINI machine. The experimental results were exploited to validate a simplified heat transfer model introduced in this work. The results indicate that the addition of helium to the process gas lowers the amount of fumes and incandescent spatters and thus could decrease evaporation. Also, it was found that the higher thermal conductivity of helium compared to argon leads to significantly higher cooling of process by-products.
Some observations on additive manufacturing
Authors: Steen William Maxwell
Published: November 2022

Some comments on how Jyoti Mazumder started his laser career, how additive manufacturing (AM) started, and where it is going.
Comparison of Nutritional Characteristics of Fresh and Freeze-Dried Donkey Milk
Authors: P Polidori
Published: November 2022

This study was performed in order to compare the chemical and nutritional properties of raw donkey milk and reconstituted milk samples made from freeze-dried donkey milk powder. Fresh donkey milk samples were collected from 18 Ragusana breed pluriparous donkeys. The freeze-drying process was performed on fresh milk using a lyophilizer programmed to operate for 1 h initial freezing at - 45°C followed by primary drying at 30 °C at 0.10 mbar pressure for 48 h and secondary drying at 5°C for 3 h at the same pressure. Reconstituted milk (90%, wb) was prepared dissolving 0.9 g of freeze-dried donkey milk in 10 ml of distilled water. Nutritional properties of freeze-dried donkey milk remained basically unchanged compared with fresh milk, obtaining very similar values as regard chemical composition, fatty acid profile and minerals content in both kind of milks. The results of the present study confirmed that freeze-drying is a relatively sparing method for preservation of short-lived products due to the fact that the main quality parameters of fresh milk are not significantly affected by the treatment, while the transport and the storage costs of freeze-dried milk are greatly reduced.
Keratin Degradation by Aspergillus niger and Penicillium purpurogenum Isolated from Nigerian Soil
Authors: AI Ogbonna
Published: November 2022

Keratin degrading Aspergillus niger and Penicillium purpurogenum were isolated from soils collected from human hair dumping ground using skim milk agar screening method. These fungi hydrolyzed skim milk casein indicated by halo zones of hydrolysis of 62mm and 64mm produced by them respectively. The fungal species also utilized keratin of ground human hair and chicken feather and hydrolyzed them to reducing sugars and proteins with P. purpurogenum being a better degrader of chicken feather and human hair producing 13.5 and 12.0 U/ml respectively than A. niger.
The Nutritional Value of Improving Dried Lentil Soup
Authors: ST El-Hadidie
Published: November 2022

The main objective of this investigation is to prepare a quick and high quality lentil soup characterized with nutritional value in the form of powder from formulated dried soups. Dried soup mixtures formulated by lentil, mushroom, egg powder and dried sweet whey at different ratio. Three formulas were prepared and compared with lentil soup only for organoleptic properties, color, rehydration ratio, proximate analysis and energy, total phenolic compounds, antioxidant activity, amino acids profile and water activity during storage at room temperature. The organoleptic evaluation of different dried soup mixtures showed that the control lentil soup (M1) recorded the highest score (46.05) followed by died whey soup (M4) (45.05). Color measurements indicated significantly increases in lightness, redness and yellowness values. The M4, M2and M3 formulas, recorded the highest value respectively. The rehydration ratio resulted in significant increase for control, and those containing mushroom and egg powder (M1, M2, and M3), main while the presence of dried whey showed significant decrease. The chemical composition indicated that the M3 formula had the highest protein content followed by M2 and M4 compared with control. Fat and fiber content in the different soup mixtures had no significant differences as well as total carbohydrates which had the highest values in M4 followed M1, M2 and M3, respectively. The obtained results revealed that different dried lentil soup mixtures may contain a sufficient amount of minerals (Fe, Zn, Ca, and Se) to cover the human mineral requirements and also a good source of phenolic acids and antioxidant activity. The major essential amino acid in the different mixtures (M2,M3 and M4) soups was leucine which found in high amounts followed by lysine and valine compared to the control (M1) .The major non- essential amino acids were glutamic, aspartic and arginine acids followed by serine, alanine and proline which were nearly, similar all different soups mixtures. The water activity of different soups mixes increased with progressive the storage period with the type of packaging materials. The overall increase was laid safe limits was aw=o.6. From the obviously results it could be recommended that the lentil, mushroom, egg and whey powders could be a common new and successful ingredient to use in preparing a novel generation of healthy food products. The formulas from these ingredients increased the nutritional value, antioxidant activity and the amino acids. Finally, high quality and nutritional properties of different lentil soups mixtures were in order of M3 M2 and M4, comparable by M1 as a control.
Lessons of Consolidation Processes of Ukrainian Community of Western Ukraine in the First Quarter of the Xx Century
Authors:   Lviv Polytechnic National University, Panfilova Tetiana
Published: November 2022

The domestic and foreign policy circumstances of the consolidation aspirations of Ukrainians in Western Ukraine in the first quarter of the twentieth century is analyzed. The search for a common path, unification of political parties and their consolidation for the common goal of protecting the socio-economic and national-political rights of Ukrainians formed on both sides of the Dnipro River awareness of the need for unity, independence and unity in creating their own state. The ways and means of political struggle of various parties and organizations indicated the search for a common course in overcoming the denial by international structures of the existence of young sprouts of Ukrainian statehood. The reasons for its failures and the consequences for further consolidation of national- patriotic forces in Western Ukraine have been clarified. At the turn of the nineteenth and twentieth century’s, political parties and organizations in Eastern Galicia clearly outlined the program of their activities: protection of socio-economic and national-political rights of Ukrainians in the Austro-Hungarian Empire and consolidation of the Ukrainian people and intellectual structures to restore state independence and unity. Depending on the domestic and international situation, the program of actions of political parties was improved and concretized. This is the time of the First World War and the Ukrainian national-democratic revolution in the Russian and Austro-Hungarian empires, with the proclamation of the Ukrainian People’s Republic and the Western Ukrainian People’s Republic, during the struggle against Poland’s attempts to annex Eastern Galicia in 1918–1923. After the decision of the Council of Ambassadors of the Entente on March 14, 1923 on the transfer of Eastern Galicia to Poland, the national and patriotic forces of the region, deeply analyzing the reasons for the defeat of national liberation struggles, tried to understand the real situation and determine further action. It is clear that various political parties and groups have assessed the causes of the defeat in their own way, as well as ways and means of overcoming this situation, offering their vision of resolving the Ukrainian issue in Galicia and all Ukrainian lands enslaved by foreign states.
Pelatihan Gizi Olahraga Untuk Atlet, Pelatih, dan Guru Pendidikan Jasmani
Authors: Kurniawan Candra , Surisman Surisman , Adi Adi S , Dwi Dwi Priyono
Published: November 2022

Sports nutrition is a science that studies the relationship between the management of nutritional needs with performance that is beneficial for health, fitness, growth, and fostering sports achievement. The purpose of this PkM activity is to expand the knowledge and understanding of sports, increase competence and develop skills in compiling the need for good nutritional intake for sports through activities. The method used in this PkM activity uses a lecture approach, discussion, guided practice, and evaluation. Furthermore, this PkM activity provides valuable results and conclusions. It positively impacts various knowledge and understanding of the critical role of sports nutrition for the audience of athletes, sports coaches, and physical education teachers, as well as developing skills in formulating appropriate nutritional intake needs in sports activities.
Manajemen Stres bagi Guru pada Masa Pandemi Covid-19
Authors: Rini Riswanti , Utaminingsih Diah , Widiastuti Ratna , Oktariana Yohana
Published: November 2022

The outbreak of the Corona Virus Disease 2019 (Covid-19) pandemic since December 2019 until now requires all teaching and learning activities for students to be temporarily carried out at home. This needs to be done in order to minimize mass physical contact so that it can break the chain of spreading the virus. To fill the teaching and learning activities that must be completed in this academic year, the government has adopted a policy of learning to be carried out through distance learning using online media (on the network), either using a cellphone, PC, or laptop.
Online learning that has been running, makes teachers also cause stress because of the large number of classes and students and demands from conditions or praxis that cause many problems. In an emergency situation, the teacher at that time had to act quickly so that learning could run effectively. Teachers need to be quick to take action and manage classes remotely. This includes managing materials and tasks of very short duration. In a short period of time there are obstacles that occur both from the side of the teacher and the students.When experiencing stress, the body will unconsciously manage stress. Management in dealing with stress is a way to increase his immunity to stress. Effective stress management will result in permanent adaptation, giving rise to new habits or improvements from old situations, while ineffective stress management will end up being maladaptive, namely deviant behavior and harm to oneself and others.
MENINGKATKAN KETERAMPILAN MOTORIK KASAR GERAK MANIPULATIF ANAK USIA 4-5 TAHUN
Authors: Pradini Susanthi , Sugiana  , Dwi Jayanti Kurnia Dewi  , Tommy Rizki Prasetyo
Published: November 2022

The number of kindergarten teachers who have difficulty in providing activities to develop gross motor skills in their students. Based on these problems, this service aims to improve the ability of teachers to provide gross motor learning activities, especially manipulative movements for early childhood. This service is designed with the following steps: 1) initial design; 2) prepare manual manual for gross motor manipulative motion; 3) training; 4) evaluation of training activities; 5) implementation of manual manual manual manipulative movements of children aged 4-5 years. The results of this dedication indicate that gross motor training of manipulative movements for children aged 4-5 years for kindergarten teachers is very effective for kindergarten teachers. This can be explained by the difference in the mean results of the pre-test and post-test of 36. Which means that there is an increase in the knowledge and skills of kindergarten teachers regarding gross motor skills of manipulative movements, with increasing teacher skills, the gross motor skills of students also increase.
Workshop : Gamification Untuk Penguatan Karakter Peserta Didik Sekolah Dasar di Kota Metro
Authors: Sukamto Ismu , Efendi Ujang , Khairani Fadhilah , Maulina Hervin , Hermawan Jody Setya
Published: November 2022

Characteristics of elementary school students (SD) are more dominant in psychomotor activity. Classroom learning should accommodate this so that student motivation is maintained during the learning process. Motivation is important considering that mastery of knowledge will be more optimal if students enjoy the learning process. Traditional learning is still found in Way Kanan Regency, so it is necessary to learn that accommodates these characteristics. One way that is considered appropriate is the application of the concept of gamification. The purpose of this service is to provide counseling and learning training with the concept of gamification to elementary school educators, develop the potential of students who are not yet optimal due to traditional learning, and foster the spirit of professionalism of elementary school educators. This service uses counseling and training methods and involves 25 educators in Way Kanan Regency. The instruments used are tests and portfolios as measuring tools to evaluate and sustain service. This service is expected to be a reference for innovative and productive learning to improve the character of students as a provision to face the challenges of the digital era.
Optimasi bubuk bunga telang, enzim transglutaminase, dan bread improver untuk meningkatkan fungsionalitas dan kualitas roti manis [Optimizing the butterfly pea powder, transglutaminase enzyme, and bread improver to improve the functionality and quality of sweet bread]
Authors: Wulandari Endah , Ishmayana Safri , Marta Herlina , Fadhlillah Muhammad , Isnaeni Nurisa Fadillah
Published: November 2022

Sweet bread with moderate functional properties can be enhanced with tertiary function by adding telang flower, a natural ingredient rich in antioxidants, natural blue in color derived from anthocyanins. In addition, bread volume enhancers, such as transglutaminase enzymes and bread improvers are also needed to improve the quality of bread. The purpose of this study was to determine the optimum formulation of telang flower sweet bread using Response Surface Method (RSM)-Central Composite Design (CCD) with telang flower powder (2-6%), transglutaminase enzyme (0.027-0.083 U/g protein), and breading agent (3-9 U/g flour) as an independent variable, and produces a response in the form of specific volume and antioxidant activity. The optimum formula was obtained with a combination of 4.71% telang flower powder formula, transglutaminase enzyme 0.055 U/g flour protein, and 5.23 U/g flour bread improver which resulted in a specific volume of 3.15 ± 0.05 cm3/g and activity antioxidant amounted to 388.372 ± 13.11%. The characteristics of the optimum bread had firmness values of 629.77±39.23 g.f, springiness 42.14±0.87%, sweet bread crumbs were dark blue, but the butterfly  pea flower sweet bread's quality was not as well accepted as the control sweet bread with the exception of how the bread feels when bitten.
Pengaruh penambahan kacang merah dan ketan hitam terhadap sifat sensori dan gizi minuman berbasis jamur tiram dan wijen hitam[[The effect of the addition of red beans and black glutinous rice on the sensory and nutritional properties of oyster mushroom and black sesame-based drinks]
Authors: Yustiana Anisa , Nurdjanah Siti , Nurdin Samsu Udayana , Murhadi Murhadi , Sartika Dewi
Published: November 2022

One example of a plant-based product is mixed grain-based milk. Mixing various types of grains such as red beans, black glutinous rice, black sesame, and oyster mushrooms is expected to complement the nutritional content and improve the sensory properties of the final product. This research was aimed to determine the effect of the proportion of red beans and black glutinous rice on the mixture of grains and oyster mushrooms on the  sensory quality of mixed grain milk and find the best proportion of red beans and black glutinous rice in the mixture of grains and oyster mushrooms that produce plant-based milk with the best sensory quality. This research was conducted in a Randomized Complete Block Design (RCBD) with a single treatment in the form of a comparison of red beans, and black glutinous rice consisting of 6 formulations with 4 replications. Parameters observed were sensory properties (aroma, taste and aftertaste). The sample with the best sensory properties was further analyzed proximate content and amino acid profile. The results showed that addition of red beans and black glutinous rice to plant-based milk on oyster mushrooms and black sesame affected sensory qualities (taste, aroma, and aftertaste).  The best treatment was the proportion of 60:30 with a taste score of 7.49 (tends to be savory sweet), an aroma score of 7.73 (tends to be pleasant), an aftertaste score of 7.11 (tends to be normal); a moisture content of 85.29%; a protein content of 1.72%;  fat content 0.88%; carbohydrates 11.77%; ash 0.34%; and 61.88 kcal of calories per 100 mL.
Inovasi pembelajaran berbasis teknologi Artificial Intelligence dalam Pendidikan di era industry 4.0 dan society 5.0
Authors: Putri Supriadi Salsabila Rheinata Rhamadani , Haedi Sulistiyani Usman , Chusni Muhammad Minan
Published: November 2022

Penelitian ini membahas mengenai perancangan cara pembelajaran yang inovasi dengan berbasis teknologi AI (Artificial Intelligence) di era society 5.0. focus penelitian terletak pada proses pembelajaran dengan teknologi AI. Tujuan penelitian ini adalah untuk menjadikan teknologi AI dalam dunia Pendidikan sebagai alat dalam mendukung pengembangan pengetahuan dalam pembelajaran. Dalam penelitian ini menggunakan jenis library research (kepustakaan). Penelitian yang dilakukan dengan cara mengkaji dan menganalisis sumber primer dari buku, jurnal ilmiah, artikel dan dokumen yang relevan dengan pembahasan. Penerapan AI (Artificial Intelligence) bagi dunia pendidikan akan membawa terobosan baru dalam penerapan pembelajaran, berbasis Ilmu Pengetahuan dan Teknologi (IPTEK) di abad ke 21. Kemampuan orang tua dan guru dalam memahami pengembangan Ilmu Pengetahuan dan Teknologi (IPTEK), ditingkatkan dengan hadirnya teknologi AI. Oleh sebab itu, diharapkan dengan adanya penelitian ini akan memicu pemahaman AI dalam bidang pendidikan.
Various temperature effects on spikelet growth in hulless oat during grain-filling stage
Authors: Ko Chan Seop , Lee Joo Sun , Seo Yong Weon
Published: November 2022

Temperature conditions affect growth and grain development during the grain-filling stage, but a comprehensive analysis of oat subjected to different temperatures during grain development has not been studied. In this study, an integrated physiological and proteomic examination of oat spikelets was performed to analyze the influence of five different day-time temperatures on stress-relative parameters and grain development. Physiological analysis showed decrease of total chlorophyll, shoot dry weight and spikelet shape development and increased activation of MDA, soluble sugar and antioxidant enzymes, with increase of temperatures. However, considering major grain yield components and storage materials, there should be an optimum temperature during ripening period. The result of proteomic analysis showed significantly high expressions of stress-related gene in high temperature treatment and grain storage materials in optimum temperature. Our findings indicate that temperature conditions during the grain-filling period exert a major influence on yield potential.
Hoitoprosessien uudistamattomuus haastaa terveydenhuollon digitalisaatiota
Authors: Koivuluoma Minna , Haverinen Jari , Reponen Jarmo
Published: November 2022

Suomi tavoittelee digitalisaation edelläkävijyyttä uudistamalla julkisten palvelujen prosesseja ja sähköistämällä palveluja. Terveydenhuollossa sähköisten asiointipalvelujen käyttöönotolla tavoitellaan yhä parempia terveydenhuollon palveluita ja kustannushyötyjä. Sähköisten asiointipalveluiden käyttö on viime vuosina lisääntynyt, mutta käyttömäärä on edelleen alhainen digitalisaation toteutumiseksi. Sähköisten asiointipalveluiden käytön lisääntymisen yhdeksi haasteeksi on havainnoitu hoitoprosessien uudistamattomuus.
Etelä-Pohjanmaan sähköisten asiointipalveluiden parantamiseksi, tämän tutkimuksen tavoitteena oli selvittää, miten terveydenhuollon hoitoprosessit huomioidaan sähköisten asiointipalveluiden kehittämistyössä Etelä-Pohjanmaalla. Tavoitteen saavuttamiseksi tutkittiin, millaisia sähköisiä asiointipalveluja terveydenhuollossa on käytössä ja kehitteillä, millaiseksi sähköisten asiointipalveluiden käytön yleisyys arvioidaan, millainen sähköisten asiointipalveluiden ja terveydenhuollon hoitoprosessien yhteenliittymä on, millä tavoin sähköisten asiointipalveluiden kehittämistyötä toteutetaan ja mitkä ovat Covid-19-pandemian vaikutukset sähköisiin asiointipalveluihin terveydenhuollossa.
Tutkimuksen lähtökohta kuvattiin kirjallisuuskatsauksella, jossa haettiin tietoa terveydenhuollon sähköisistä palveluista Pohjoismaista. Tiedot terveydenhuollon hoitoprosessien huomioimisesta sähköisten asiointipalveluiden kehittämistyössä kerättiin terveydenhuollon ja tietohallinnon ammattilaisten haastatteluista.
Terveydenhuollossa on käytössä erilaisia sähköisiä asiointipalveluja, joita on tarpeen kehittää sujuvamman asiointikokemuksen mahdollistamiseksi. Sähköisten asiointipalveluiden käyttöönottojen yhteydessä tehdään muutoksia hoitoprosesseihin, mutta prosesseja ei uudisteta suunnittelemalla, miten sähköisten palvelujen hyödyt saavutetaan. Sähköisten asiointipalveluiden kehittämistyötä toivottiin edistettävän ja sisällyttämään työhön prosessisuunnittelu entistä vahvemmin. Sähköisten palveluiden ja prosessien muotoilulle yhtenäiseksi kokonaisuudeksi on olemassa hyvät edellytykset. Tulevaisuudessa on tärkeää määritellä sähköisten asiointipalveluiden hyötytavoitteet ja tehdä strategia niiden saavuttamiseksi. Sähköisten asiointipalveluiden hyödyt konkretisoituvat, kun määritellyt prosessivaiheet digitalisoidaan siten, että ne ovat osa työkäytänteitä ja kansalaisten asiointia.
Sosiaali- ja terveydenhuollon sähköisten vastaanottopalveluiden käyttö kaupunki-maaseutu-alueluokituksen mukaan Suomessa
Authors: Vehko Tuulikki , Kyytsönen Maiju , Ikonen Jonna , Koskela Timo , Kainiemi Emma , Parikka Suvi
Published: November 2022

Sähköistä asiointia kohtaan on asetettu terveyspoliittisia tavoitteita harvaan asutuissa länsimaissa. Sosiaali- ja terveydenhuollon palveluita voidaan toteuttaa soveltuvin osin sähköisinä palveluina. Sähköisten palveluiden käyttö edellyttää asiakkailta välineitä sekä osaamista ja tietoa palveluista, joihin hakeutua.
Selvitimme sähköisten sosiaali- ja terveydenhuollon vastaanottopalveluiden käyttöä eri alueilla. Tutkimus perustuu satunnaisesti valittujen 20–99 vuotiaiden henkilöiden antamiin vastauksiin aikuisväestöä edustavassa FinSote 2020 kyselytutkimuksessa (n=28 199, osallistumisaktiivisuus 46 prosenttia). Alueluokituksena käytettiin seitsemänluokkaista kaupunki-maaseutu-alueluokitusta. Tulokset esitetään työikäisille (20–64 vuotiaat) ja eläkeikäisille (65–99 vuotiaat) väestöä edustavina osuuksina vakioimattomina ja demografisten tekijöiden suhteen vakioituna. Sähköisesti vastaanottopalveluita käyttäneiden osuus laskettiin edeltävän vuoden aikana sosiaali- tai terveyspalveluja käyttäneistä. Vastaajan antama arvio siitä, korvasiko sähköinen asiointi vähintään yhden perinteisen soiton tai käynnin, laskettiin sähköisiä sosiaali- ja terveyspalveluja käyttäneistä.
Kaupunkimaisilla alueilla käytettiin useammin sähköisiä vastaanottopalveluja verrattuna maaseutumaisiin alueisiin. Sosiaali- tai terveydenhuollon palveluita käyttäneistä työikäisistä 39 prosenttia oli käyttänyt sähköisiä vastaanottopalveluita sisemmällä kaupunkialueella, kun vastaava osuus harvaan asutulla maaseudulla oli vain 25 prosenttia. Eläkeikäisistä nämä osuudet olivat pienempiä: sisemmällä kaupunkialueella 13 prosenttia ja harvaan asutulla maaseudulla kahdeksan prosenttia. Kun työikäisistä 86 prosenttia ulommalla kaupunkialueella ja 75 prosenttia maaseudun paikalliskeskuksissa raportoi sähköisen asioinnin korvanneen vähintään yhden perinteisen käynnin, niin eläkeikäisillä osuudet olivat pienempiä: 70 prosenttia sisemmällä kaupunkialueella ja 54 prosenttia harvaan asutulla maaseudulla.
Sähköisesti sosiaali- ja terveydenhuollon vastaanottopalveluita käyttäneiden osuus oli melko korkea. Sähköisten vastaanottopalveluiden käyttö oli yleisempää kaupunkialueella kuin harvaan asutulla maaseudulla. Ne, jotka olivat asioineet sosiaali- ja terveydenhuollossa sähköisesti, arvioivat useimmiten, että sähköinen asiointi korvasi perinteisen käynnin. Työikäiset käyttivät sähköistä vastaanottopalvelua useammin kuin ikääntyneet.
Sähköiset palvelut mahdollistavat asioinnin myös harvaan asutuilla seuduilla. Se, miten pitää välineet kaikkien tavoitettavissa, miten voidaan kohentaa osaamista ja tukea sähköisten palveluiden käyttöön ovat haasteita, joihin sosiaali- ja terveyspolitiikan sekä työllisyys- ja koulutuspolitiikan keinoin on vastattava.
Third-order critical family therapy: rethinking psychopathology and psychotherapy
Authors: Medina Centeno Raúl
Published: November 2022

Background: The focus of third-order critical family therapy is to raise awareness of the systems of systems – structural, socioeconomic and cultural contexts– that organize lifestyles that interfere with health. This clinical proposal integrates systemic wisdom with social theories, and in particular delves into a sociocultural theory of the human mind, power and emotions, a set of concepts from which indignant love, solidarity dialogue, critical honesty emerge, as the axes from which clinical work is woven. The ultimate goal is for the family to restore critical solidarity dialogue and empower themselves in their well-being. Method: Our study is narrative. Conclusion: This clinical proposal leads to re-thinking psychopathology not as an individual or biological problem, but as a resistance to those contexts of belonging that excludes and mistreats, and therefore to diagnosis as an active organized social framework. And on the other hand, also to psychotherapy and psychotherapist who must always be critically attentive to explain the androcentrist, classist and Eurocentric privileges of clinical theory and practice, to become health professionals with a social, human, political and ethical perspective.
Cows enrolled in a pilot randomized clinical trial evaluating pegbovigrastim administered to dairy cows at dry-off had reduced incidence of intramammary infection
Authors: de Campos Juliana Leite , Strickland Jaimie M. , Gandy Jeff C. , Robison Cara I. , Ruegg Pamela L.
Published: November 2022

OBJECTIVE

The objective of this pilot study was to determine if an alternative dosing schedule of pegbovigrastim (PEG; Imrestor; Elanco Animal Health) affects mammary gland health, rear udder width, or milk production of healthy dairy cows.

ANIMALS

20 pregnant late-lactation Holstein cows in November 2019 through April 2020.

PROCEDURES

Cows were randomly assigned to receive subcutaneous injections with either 15 mg of PEG (PEG group; n = 10) or a sham injection with saline (0.9% NaCl) solution (control group; 10) administered 7 days before dry-off and at dry-off. Quarter milk samples were collected for bacterial culture and somatic cells before and after dry-off and after calving. Mammary gland width was assessed before and after dry-off. Daily milk yields were evaluated after calving.

RESULTS

The incidence of intramammary infection was 5 times greater for quarters of cows in the control group than for quarters of cows that received PEG. The effect of treatment on somatic cell count was not significant, but the effects of period and a treatment-by-period interaction were identified. Treatment did not significantly affect milk production in the subsequent lactation, but the effects of period and an interaction of treatment by period were identified. Rear udder width after dry-off was not significantly affected by treatment, but an effect of period was identified.

CLINICAL RELEVANCE

In this pilot study, cows treated with PEG using an alternative dosing schedule had reduced incidence of intramammary infection and an interaction of treatment by sampling period was observed for milk yield. These results suggest that further studies with larger numbers of cows are warranted.
DIGITAL TRANSFORMATION AND SUSTAINABLE ENTREPRENUERSHIP IN FOOD SUPPLY CHAIN
Authors:   Bucharest University of Economic Studies, Bucharest, Romania, Negruțiu Cristian
Published: November 2022

Food logistics is a critical sub-category, with major implications for society, in which tech entrepreneurs can bring a significant paradigm shift. We will investigate these changes through the concept of green entrepreneurship and by briefly describing the EU strategy called Farm to Fork. In order to demonstrate that the change is already happening, we will present a case study featuring a tech start-up from Romania. The company is a successful application of sustainable entrepreneurship in the logistics and supply chain area and a practical exemplification of the Farm to Fork strategy.
Maurits Cornelis Escher
Authors: P. SANTOS CARLOS
Published: November 2022

In 1958, the Dutch graphic artist Maurits Cornelis Escher (1898-1972) published his book Regelmatige Vlakverdeling (The Regular Division of the Plane), including perfect tessellations where shapes or combinations of shapes interlock to cover the plane. In this paper, we analyse the geometry behind Escher’s tessellations, transition devices, and an interesting interaction between Escher and the British mathematical physicist and philosopher Roger Penrose (1931-, Nobel Lau- reate in 2020).
Fullerene-Like Architecture of Pollen
Authors: Delusina Irina , Katz Eugene
Published: November 2022

The paper presents observations of the similarity of external grain shape and symmetry characteristics of the internal structure of pollen and spore grains of plants with the molecular structure of fullerenes. It is suggested that the fullerene-like structures observed in sporopollenin- containing pollen and spores leads to minimization of the energy and matter resources of grains in their life span as well as maximizes their strength and pollination effectiveness.
Clinical and laboratory characteristics of haemophilus influenza type b Infection with central nervous system Involvement in young children
Authors: Sitkina E. L. , Antonova T. V. , Ivanova R. A. , Lioznov D. A.
Published: November 2022

Introduction. Invasive Haemophilus influenza type b (Hib) infection often manifests as severe and complicated forms of purulent meningitis in children from birth to 6 years of age. Hib meningitis is the most commonly diagnosed invasive form, with a severe course. There is no generally accepted clinical classification of Hib infection. Along with meningitis, the infection is often manifested with purulent inflammatory foci of different localization.

The objective was to characterize the course of purulent Hib meningitis, including in combination with purulent foci, in young children.

Methods and materials. We analyzed 45 case histories of children (under the age of 3 years) who had an invasive Haemophilus infection with purulent meningitis. Hib meningitis (Group-1) was diagnosed in 17 patients and meningitis in combination with specific purulent foci was diagnosed in 28 patients (Group-2). The diagnosis in all patients was confirmed bacteriologically or serologically (Latex Agglutination Test).

Results. The combination of meningitis with purulent foci of Hib infection was characterized by late hospitalization (36 %), longer recovery of cerebrospinal fluid, longer duration of the disease, and the prevalence of severe and complicated disease, and often required surgical treatment (46.4 %). A burdened premorbid background is traditionally considered a condition for the development of invasive Hib infection. According to our data, only 40 % of children had a burdened premorbid background, which is confirmed by clinical cases.

Conclusion. Since Hib infection in young children is often combined with meningitis with purulent foci, is characterized by a severe and complicated course, and often requires surgical treatment, it is advisable to consider this form of infection separately.
On the development of new cancer quality of life questionnaires
Authors: Shchelkova O. Yu. , Iakovleva M. V. , Usmanova E. B. , Yeremyan Z. A. , Sushentsov E. A. , Tsyrenov D. D.
Published: November 2022

The article is devoted to summarizing the authors’ experience in the development of Russian-language versions of foreign quality of life questionnaires for cancer patients as well as their own questionnaires for studying various aspects of the quality of life in bone and soft tissue tumors of the musculoskeletal system. We briefly presented the results of the validation and testing of the modules of the «Cancer Quality of Life Questionnaire - Core 30» (EORTC QLQ-C30) developed by the Quality of Life Assessment Group at the European Organization for Research and Treatment of Cancer (EORTC) – «Fatigue» module (FA12), «Spiritual wellbeing» module (SWB32), «Bone Metastases» module (BM22), as well as the specialized Spine Oncology Study Group Outcomes Questionnaire (SOSG-OQ). We also presented the diagnostic tools developed by the authors’ themselves for studying the quality of life of patients with pelvic bone tumors and lower limb amputations due to cancer. The main objective of the article was to inform the scientific community, as well as practicing psycho-oncologists and oncologists about the existence of new diagnostic tools for assessing the quality of life of cancer patients. The article also outlines the prospects for development of diagnostic tools for quality of life of cancer patients.
Dopamine receptor DRD1 expression (mRNA, protein level) in peripheral blood lymphocytes and prognosis of antipsychotic therapy
Authors: Zabotina A. M. , Zhuravlev A. S. , Grunina M. N. , Nasyrova R. F. , Volkova E. V. , Tyurin A. A. , Limankin O. V. , Otmakhov A. P. , Krupitsky E. M. , Neznanov N. G. , Taraskina A. E.
Published: November 2022

Introduction. There is a problem in predicting the efficacy and safety of antipsychotic therapy. Dopamine receptor D1 is one of the targets of antipsychotics. Peripheral blood lymphocytes (PBL) are the research object of neurotransmission receptors.

The objective was to study DRD1 gene expression (mRNA, protein level) in PBL as a possible biomarker of olanzapine and haloperidol therapy prognosis.

Methods and Materials. Sample: 106 patients diagnosed with schizophrenic spectrum disorder. Study design: prospective longitudinal follow-up with drug administration by randomization. Assessment of mental status and development of Parkinsonism: Positive and Negative Syndrome Scale (PANSS) and Simpson-Agnus Scale (SAS), respectively. PBL was study material. DRD1 mRNA level was determined by real-time PCR. DRD1 protein concentration in PBL was measured by enzyme immunoassay.

Results. Haloperidol (but not olanzapine) treatment for 28 days, leads to DRD1 protein concentration decrease in PBL in a manner dependent on its initial level. DRD1 mRNA level in PBL remained unchanged during the treatment. Patients with effective therapy by olanzapine had lower DRD1 mRNA levels. Side effects of the therapy (Parkinsonism, weight gain) were not associated with studied DRD1 parameters.

Conclusions. Haloperidol treatment leads to a decrease of DRD1 protein concentration in PBL, which depends on the initial protein level. Effective olanzapine therapy is associated with reduced DRD1 mRNA level in PBL before the treatment.
Ventral posteromedial nucleus of the thalamus as a neuroanatomical target for the anticephalalgic action of valproic acid and metamizole
Authors: Sokolov A. Yu. , Lyubashina O. A.
Published: November 2022

Introduction. Valproic acid and metamizole are widely used in the treatment of primary headaches. However, despite the drugs’ proven clinical efficacy, the neurophysiological mechanisms underlying their therapeutic action are poorly understood. The ventral posteromedial nucleus of the thalamus (VPM) serves as the highest suprasegmental relay center for transmitting ascending nociceptive information from the cranial structures to the cerebral cortex and is considered as a potential neuroanatomical target for anticephalalgic drugs.

The objective of the study was to evaluate the action of valproate and metamizole on the excitability of the VPM thalamic neurons.

Methods and materials. In acute controlled experiments on anesthetized rats (n=31), we studied the action of cumulative dosing (three fixed dose injections every 30 minutes) of intravenously administered valproate (n=8, 100 mg/kg x 3) or metamizole (n=16,150 mg/kg · 3) on extracellularly recorded background and dura mater electrical stimulation-evoked activities of the convergent VPM neurons. Results. In all experiments, intravenous valproate significantly inhibited both background activity of the VPM neurons and their responses to dural electrostimulation. Metamizole had a similar action in more than half of the cases, whereas 44 % of the examined thalamic cells (7 out of 16) did not react to its infusion.

Conclusion. One of the main neurophysiological mechanisms underlying anticephalalgic action of valproic acid and metamizole may be inhibition of the nociceptive transmission at the thalamic level due to the drugs-induced suppression of the meningeal-sensitive VPM neurons excitability.
Epidemiology and results of the first line therapy for HIV-related Hodgkin lymphoma
Authors: Chekalov A. M. , Popova M. O. , Tsygankov I. V. , Rogacheva Yu. A. , Volkov N. P. , Lepik K. V. , Demchenkova M. V. , Schneider T. V. , Kopeikina Yu. V. , Medvedeva N. V. , Zyuzgin I. S. , Pavlyuchenko E. S. , Levanov A. N. , Myasnikov A. A. , Kariagina E. V. , Mikhailova N. B. , Baykov V. V. , Kulagin A. D.
Published: November 2022

Introduction. The risk of developing Hodgkin lymphoma (HL) with HIV infection is higher than in the general population, and the course of the disease itself is more aggressive. Currently, there is no unified approach to the treatment of HIV-related HL, and data on its epidemiology in the Russian Federation are limited.

The objective was to study epidemiological characteristics, the used therapeutic tactics and the results of treatment for HIV-related HL.

Methods and materials. The multicenter retrospective study included 46 patients with HIV- related HL treated in 9 centers of the Russian Federation. Descriptive statistics methods were used, the analysis of overall survival (OS) and progression-free survival (PFS) was performed using the Kaplan–Meier method.

Results. HIV-related HL is more often represented by an advanced stage, B-symptoms, and extranodal lesions. The ABVD regimen was used as the first-line therapy in 60 % for HIV-related HL. The overall response to therapy was 81.6 %, and the 2-year OS and PFS were 85 % and 49 %, respectively. Factors that worsened OS were CD4+˂266 cells/mcL and general somatic status ECOG≥2.
In-Hospital Clinical Ooutcomes of COVID-19 Patients Treated with Oral Anticoagulants
Authors:   Sakarya University Education And Research Hospital, Sahinkus Salih
Published: November 2022

Objective: We aimed to investigate the effects of warfar in and new-generation oral anticoagulants on the prognosis of patients diagnosed with Corona Virus Disease 2019 (COVID-19). Materials and Methods: Patients diagnosed with COVID-19 were divided into two groups depending on whether they were using warfarin or a new-generation oral anticoagulant. The types of chronic diseases, drugs used, haematological and biochemical parameters and prognoses in each group were statistically analysed. Results: Twenty-three patients (37.1%) using warfarin and 39 (62.9%) patients using new-generation oral anticoagulants were included in the study. There was no significant difference between the two groups in terms of demographic characteristics and laboratory data. The mortality rates for the warfarin and new-generation anticoagulant groups were similar (39.1% vs. 43.6%, respectively; p = 0.731). Conclusion: There was no difference in the effects of warfarin and new-generation oral anticoagulants on mortality among the patients with COVID-19.
Orthostatic hypotension in elderly: Do you measure orthostatic and clinostatic blood pressure?
Authors: Cacciatore Stefano , Spadafora Luigi , Landi Francesco
Published: November 2022

In this article we highlighted the blood pressure management in elderly patients with orthostatic hypotension.