bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study
Authors: Wallin Helena , Jansson Eva , Wallquist Carin , Rössner Britta Hylander , Jacobson Stefan H , Rickenlund Anette , Eriksson Maria J
Published: December 2019

Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. In a 5-year-prospective study, we evaluated exercise capacity and known determinants of exercise capacity in patients with mild-to-moderate CKD attending a specialist nephrology clinic. Methods: We included 52 individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results: Exercise capacity did not change significantly over time in either CKD individuals or controls, although the absolute workload levels were significantly lower in CKD individuals. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Physical activity level increased over 5 years only in the CKD group. Conclusions: Aerobic exercise capacity and peak heart rate are maintained over 5 years in a group of patients with well-controlled CKD grade 2–3, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group.
Production of ERCP training model using a 3D printing technique (with video)
Authors: Kwon Chang-Il , Shin Yeonsun , Hong Jaeok , Im Minje , Kim Guk Bae , Koh Dong Hee , Song Tae Jun , Park Won Suk , Hyun Jong Jin , Jeong Seok
Published: December 2019

Background: ERCP training models are very different in terms of anatomical differences, ethical issues, storage problems, realistic tactile sensation, durability and portability. There is no easy way to select an optimized model for ERCP training. If the ERCP training model could be made as a soft silicone model using 3D printing technique, it would have numerous advantages over the models presented so far. The purpose of this study was to develop an optimized ERCP training model using a 3D printing technique and to try to find ways for implementing various practical techniques. Methods: All organ parts of this model were fabricated using silicone molding techniques with 3D printing. Especially, various anatomy of the ampulla of Vater and common bile duct (CBD) were creatively designed for different diagnostic and therapeutic procedures. In order to manufacture each of the designed organ parts with silicone, a negative part had to be newly designed to produce the molder. The negative molders were 3D printed and then injection molding was applied to obtain organ parts in silicone material. The eight different types of ampulla and CBD were repeatedly utilized and replaced to the main system as a module-type. Results: ERCP training silicone model using 3D technique was semi-permanently used to repeat various ERCP procedures. All ERCP procedures using this model could be observed by real-time fluoroscopic examination as well as endoscopic examination simultaneously. Using different ampulla and CBD modules, basic biliary cannulation, difficult cannulation, stone extraction, mechanical lithotripsy, metal stent insertion, plastic stent insertion, and balloon dilation were successfully and repeatedly achieved. Endoscopic sphincterotomy was also performed on a specialized ampulla using a Vienna sausage. After repeat procedures and trainings, all parts of organs including the ampulla and CBD modules were not markedly damaged or deformed. Conclusions: We made a specialized ERCP training silicon model with 3D printing technique. This model is durable, relatively cheap and easy to make, and thus allows the users to perform various specialized ERCP techniques, which increases its chances of being a good ERCP training model.
Serum Levels of Cancer Antigen 125 before Hormone Replacement Therapy are not Associated with the Clinical Outcome of Frozen Embryo Transfer Cycles among Women with Adenomyosis
Authors: Huang Ling , Chen Minghui , Wang Zengyan , Zhou Canquan , Li Yubin
Published: December 2019

Background: Serum levels of cancer antigen 125 (CA125) are reportedly closely associated with the extent of adenomyosis. However, the association between serum CA125 levels before hormone replacement therapy (HRT) and the clinical outcome of frozen embryo transfer (FET) in patients with adenomyosis is unknown.Methods: A total of 509 women with adenomyosis undergoing in vitro fertilization/intracytoplasmic sperm injection treatment between January 2013 and April 2019 were screened. Following the inclusion and exclusion criteria, the included patients were divided into two groups based on the serum CA125 levels (≤ or >35 IU/ml) before HRT. The basic characteristics and main outcomes of the two groups were compared.A receiver operating characteristic curve was used to evaluate the ability of serum CA125 levels before HRT to predict the clinical outcomes of FET. Besides, data were also separately analyzed in the GnRH agonist pretreatment subgroup. Results: There were no significant differences in clinical outcomes between the two groups of women before HRT. A receiver operating characteristic curve demonstrated that CA125 levels were not predictive of clinical pregnancy outcomes. Conclusions: Serum CA125 levels before HRT were not associated with the clinical outcomes of FET among women with adenomyosis. Hence, the discovery of other new markers is necessary.
Taste and smell function in Wolfram syndrome
Authors: Alfaro Raul Andres , Doty Tasha , Narayanan Anagha , Lugar Heather , Hershey Tamara , Pepino M. Yanina Y
Published: December 2019

BACKGROUND: Wolfram syndrome is a rare genetic disease characterized by insulin-dependent diabetes, optic nerve atrophy, sensorineural hearing loss and neurodegeneration. Although olfactory dysfunction, a classical clinical marker of neurodegenerative processes, has been reported in Wolfram syndrome, its use as a clinical marker in Wolfram is limited due to data scarcity. In addition, it is unknown whether Wolfram syndrome affects the sense of taste.METHODS: Smell and taste perception were assessed in participants with Wolfram syndrome (n=40) who were 15.1 ± 6.0 years of age (range: 5.1- 28.7 years) and two sex- and age-matched control groups: one group with type 1 diabetes mellitus (T1D; n=25) and a healthy control group (HC; n=29). Smell sensitivity was assessed by measuring n-butanol detection thresholds and smell identification by using the University of Pennsylvania Smell Identification Test (UPSIT). Taste function was assessed using NIH Toolbox, which includes the assessment of sucrose (sweet) taste preference, and perceived intensity of sucrose, sodium chloride (salty), and quinine hydrochloride (bitter) both in the tip of the tongue (regional test) and the whole mouth. RESULTS: Smell sensitivity was not significantly different among groups; however, smell identification was impaired in Wolfram syndrome, as reflected by significantly lower UPSIT scores in Wolfram syndrome compared to HC and T1D (P<0.001). Compared to participants in the control groups, participants with Wolfram syndrome had a blunted perception of sweetness and saltiness when taste stimuli were applied regionally (P<0.05), but differences in perceived intensity were no longer significant among groups when taste stimuli were tasted with the whole mouth. Groups preferred similar sucrose concentrations. CONCLUSION: Wolfram syndrome was associated with olfactory dysfunction. However, the olfactory dysfunction was qualitative (related to smell identification) and not secondary to olfactory insensitivity or diabetes, suggesting is arising from dysfunction in central olfactory brain regions. In contrast to olfaction, and despite decreased perception of taste intensity in the anterior tongue, the sense of taste was overall well-conserved in individuals with Wolfram syndrome. Future longitudinal studies of taste and smell perception in Wolfram syndrome will be important to determine the use of the chemical senses as clinical markers of disease progression.
A case report: Type II Abernethy malformation complicated with congenital polydactyly and enlargement of all cardiac chambers.
Authors: Zhu Cheng , Wang Min , Hao Qian
Published: December 2019

Background: Abernethy malformation is a kind of congenital malformation of portal vein system caused by abnormal portacaval anastomosis. It can be in combination with other congenital malformations. The major therapy of Abernethy malformation is surgery. There has been a limited number of patients since the first patient reported, leading to a limited view towards this kind of disease until now.Results: In August 2018 we treated a patient diagnosed with typeII Abernethy malformation complicated with both congenital polydactyly and enlargement of all cardiac chambers, which is extremely rare and can be a supplementary to the existing cases. Besides, the low white blood cell and platelet, the arrested megakaryocytic maturation and the positive platelet autoantibody in serum may result in misdiagnosis as immune thrombocytopenia, so we analyze the differential points between these two diseases. We treated this patient with silybin orally and advised him to make follow-up visits because of his mild liver function disorder, normal cardiac function and no other malformations or complications complicated. At the latest follow-up, we knew the condition of the patient was generally satisfactory, whether in terms of laboratory test results or his daily life experience.Conclusions: Because of some changes of spleen in form and function secondary to Abernethy malformation, in some cases, this disease has similarities with a part of blood diseases, which we should take into consideration for differential diagnosis, especially when other congenital malformations are found in combination at the same time. This case also suggests that simply conservative treatment with regular follow-up visits can be suitable for certain patients.
The Eagle Jugular Syndrome
Authors: Zamboni Paolo , Scerrati Alba , Menegatti Erica , Galeotti Roberto , Lapparelli Marcello , Traina Luca , Tessari Mirko , Ciorba Andrea , De Bonis Pasquale , Pelucchi Stefano
Published: December 2019

Background The elongation of the styloid process is historically associated with two variants of the Eagle syndrome. The classic one, mainly characterized by pain and dysphagia, and the carotid variant characterized by pain and sometimes by cerebral ischemia. We observed a further variant characterized by a styloid elongation coursing adjacent to the transverse process of C1, causing significant compression of the internal jugular vein. Methods We revised all the cases of Eagle syndrome, including the jugular variant, admitted in our Hospital in the last six years. We compared symptomatology, associated comorbidities and imaging. Data were statistically analyzed. Results Overall 23 patients were admitted to the Hospital for symptomatic elongation of the styloid process, 11 male and 12 females. The jugular variant of the Eagle syndrome is clinically delineated by significant differences, as compared to the classic variant and carotid variants. Headache was the more prominent symptom (p<.009) as well as a documented peri-mesencephalic hemorrhage was the more significant comorbidity (p<.0003). The group classic-carotid variant was characterized by ipsilateral pain respect to the jugular variant (p<.0003). CT angiography with venous phase extended to the neck veins and imaging reconstruction is highly recommended as imaging technique, complemented by color-Doppler ultrasound. Conclusions The elongation of the styloid process may have different paths which creates compression on the surrounding anatomical structures. There may be a possible association of jugular impingement by an elongated styloid process with symptoms.
CLINICAL IMPLICATIONS OF NT PROBNP LEVEL IN PATIENTS WITH MYOCARDIAL INFARCTION COMPLICATED BY ATRIAL FIBRILLATION
Authors: Tseluyko Vira , Yakovleva Larysa , ben Salem Fedia
Published: December 2019

Our aim was to study the predictive value of NT proBNP regarding the risk of AF and clinical features in acute phase of ST-segment elevation MI (STEMI). Methods. We examined 56 patients with STEMI and AF who did undergo the primary PCI. 35 (62.5 %) of patients had the new-onset AF (group 1), 21 (37.5 %) had pre-existing AF (group 2). Control group consisted of 60 patients with STEMI without AF (group 3). Results. Group 3 patients were more likely to be smokers than patients in group 2. They had lower admission heart rate and glycemia, lower NT proBNP, higher hemoglobin and ejection fraction. Patients in group 1 were more likely to have anterior MI, left anterior descending artery as an infarction-related artery (IRA) and adverse cardiac events (MACEs). Patients in group 2 had higher left atrium end-systolic diameter and were more likely to have three-vessel injury. NT proBNP correlated positively with age, admission glycemia, mean PA pressure and negatively – with GFR. ROC analysis had shown the cut-off point of NT proBNP level for prediction of AF was >1050 pg/ml. Cut-off point for prediction of the risk of MACE in STEMI complicated with AF was >2189 pg/ml. Discussion. It was shown that NT proBNP is higher in STEMI patients who have AF. Increased NT proBNP is associated with the risk of adverse events in acute STEMI phase. NT proBNP level can be utilized as AF predictor in STEMI patients and as predictor of MACEs in patients with STEMI and AF.
MODERN ASPECTS OF PATHOGENETIC TREATMENT WITH ZINC SALTS OF PATIENTS WITH WILSON'S DISEASE IN UKRAINE
Authors: Voloshyn-Gaponov Ivan
Published: December 2019

The aim – to study the effectiveness of zinc salts in the treatment of patients with neurological forms of Wilson's disease (WD). Materials and methods. The analysis of the treatment results of 128 patients with hepatocerebral degeneration (71 men and 57 women) in the State Institution “Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine” was carried out. At the time of hospitalization, the age of patients ranged from 5 to 55 years, an average of 27.3 years, and at the time of debut of the disease - from 1 year to 40 years, an average of 21.3 years. 33 patients underwent monotherapy with zinc salts, 63 – combined therapy with small doses of penicillamine and zinc salts, 32 – monotherapy with penicillamine. Results. Because of the treatment, 67.1 % of patients showed an improvement in neuropsychiatric status: speech improved significantly, tremor of the extremities and the amplitude of hyperkinesis decreased, muscle tone decreased, and cognitive functions improved. According to the international two-level rating scale (UWDRS), the total pathology index decreased by 21 points. Zinc salts are effective and low-toxic and can be the drug of choice in the treatment of patients with hepatocerebral degeneration in the pre-symptomatic stage of the disease, as well as at the stage of maintenance treatment, both as monotherapy and in combination with penicillamine. However, zinc salts and penicillamine are not enough for the treatment and rehabilitation of patients with hepatocerebral degeneration. Therefore, taking into account the clinical picture and the data of additional research methods, it is necessary to conduct courses of symptomatic treatment at least 1-2 times a year. Conclusions. Thus, it can be noted that zinc salts are very effective and low toxic, and, therefore, can be the drug of choice in the treatment of patients with HCD in the pre-symptomatic stage of the disease, as well as at the stage of maintenance therapy as a single drug, and in combination with penicillamine or other chelate drugs.
RESEARCH OF ANTIBACTERIAL PROPERTIES OF THE SURFACE OF THE TITANIUM ALLOYS VT5-1 AND VT6 CONVERTED TO ANATASE TO PREVENT BACTERIAL ADHESION
Authors: Samoilenko Oleksandr
Published: December 2019

Aim: to evaluate the effectiveness of preventing the formation of microbial biofilms on the surfaces of implants made of titanium alloys VT5-1, VT6 with a transformed surface into anatase. Materials and methods. The study was carried out in the bacteriological laboratory of the Severodonetsk multidisciplinary city hospital from January 2019 to September 2019. The ability to prevent the formation of microbial biofilms of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was evaluated. The static cell adhesion method and the disco diffuse method were used. The surface of the plates was examined on a XS 6220 UCMJS05100KPA microscope. The intensity of the formation of microbial biofilms on the plates was evaluated visually by the four-cross system. Results. On all coatings with anatase, in comparison with unmodified plates, the intensity of initial adhesion and the number of bacteria fixed on the surface of the colonies markedly decreased. On surfaces with silica crystals, biofilm formation was minimal. The altered surface of titanium alloys VT5-1 and VT6 anatase and anatase with silicon dioxide crystals does not inhibit microflora growth. Conclusions. The transformed surface of titanium implants into anatase and anatase with silicon dioxide crystals prevents the fixation of biofilms of microbial associations.
Chelating modified cellulose bearing pendant heterocyclic moiety for effective removal of heavy metals
Authors: Saravanan R. , Mahalakshmi R. , Karthikeyan M. S. , Ravikumar L.
Published: December 2019

Cellulose bearing pendant Schiff base with heterocyclic chelating groups (CMC-Bz) was synthesized, which were fully characterized using various instrumental techniques such as solid state carbon-13 nuclear magnetic resonance (13C-NMR), Fourier transform infrared (FTIR), scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDX) spectra. The adsorption of toxic metals onto cellulosic material was tested in a batch mode operation. The adsorption functional factors such as pH, adsorbent dose, metal ion concentration, equilibrium time and temperature were experimentally optimized for the maximum removal of Cu(II) and Pb(II) ions. Adsorption isotherms were evaluated with Langmuir, Freundlich, Temkin and Redlich–Peterson isotherms. Kinetic parameters and equilibrium adsorption capacities were investigated for pseudo-first-order, pseudo-second-order and intra-particle diffusion models. Thermodynamic parameters and reusability were also evaluated.
Simple improvement of digested sludge quality: is postaeration the key?
Authors: Vojtiskova M. , Satkova B. , Bindzar J. , Jenicek P.
Published: December 2019

Postaeration, where digested sludge is introduced into aerobic conditions, is a technology that could improve the quality of sludge and sludge liquor in many ways. Although it is a fairly simple process, only few data about the effect of postaeration have been published. In this study, batch experiments have been performed first, indicating that postaeration affects the total ammonia nitrogen (TAN) and sludge dewaterability. In the removal of TAN, both stripping and biological oxidation can play an important role depending on specific condition. Then the postaeration was investigated in a semicontinuous batch reactor. In addition, the effect of postaeration on the concentration of selected micropollutants such as pharmaceuticals, EOX and AOX was studied. The hydraulic retention time (HRT) of 8, 6, 4 and 2 days and different aeration intensities were tested. The TAN removal efficiency achieved was about 40–60%, sludge dewaterability expressed by sludge cake total solids (TS) concentration after dewatering improved relatively by 5–30%. In addition, TS degradation is also taking place and therefore the reduction of the amount of final sludge to be disposed could be even higher. The biggest changes in observed parameters were recorded at the longest HRT.
iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease
Authors: Zhang Xiaojun , Yin Lin , Jia Xiaofang , Zhang Yujiao , Liu Tiefu , Zhang Lijun
Published: December 2019

Background:

Moyamoya Disease (MMD) is a rare cerebrovascular disease with a high rate
of disability and mortality. Immune reactions have been implicated in the pathogenesis of MMD, however,
the underlying mechanism is still unclear.

Objective:

To identify proteins related to MMD specially involved in the immunogenesis, we performed
a proteomic study.

Methods:

In this work, dural tissues or plasma from 98 patients with MMD, 17 disease controls without
MMD, and 12 healthy donors were included. Proteomic profiles of dural tissues from 4 MMD and
4 disease controls were analyzed by an isobaric tag for relative and absolute quantitation (iTRAQ)-
based proteomics. The immune-related proteins were explored by bioinformatics and the key MMDrelated
proteins were verified by western blot, multiple reaction monitoring methods, enzyme-linked
immunosorbent assay, and tissue microarray.

Results:

1,120 proteins were identified, and 82 MMD-related proteins were found with more than 1.5
fold difference compared with those in the control samples. Gene Ontology analysis showed that 29
proteins were immune-related. In particular, Haptoglobin (HP) was up-regulated in dural tissue and
plasma of MMD samples compared to the controls, and its up-regulation was found to be sex- and
MMD Suzuki grade dependent. Through Receiver Operating Characteristic (ROC) analysis, HP can
well discriminate MMD and healthy donors with the Area Under the Curve (AUC) of 0.953.

Conclusion:

We identified the biggest protein database of the dura mater. 29 out of 82 differentially
expressed proteins in MMD are involved in the immune process. Of which, HP was up-regulated in
dural tissue and plasma of MMD, with sex- and MMD Suzuki grade-dependence. HP might be a potential
biomarker of MMD.
Label-Free Mass Spectrometry-Based Plasma Proteomics Identified LY6D, DSC3, CDSN, SERPINB12, and SLURP1 as Novel Protein Biomarkers For Pulmonary Tuberculosis
Authors: Zhang Lu , Wang Hualin , Li Na , Hu Peng , Zhu Zhaoqin , Wang Wei , Song Yanzheng , Wen Zilu , Yu Xiaoli , Zhang Shulin
Published: December 2019

Aim:

We aimed to identify new plasma biomarkers for the diagnosis of Pulmonary Tuberculosis
(PTB).

Background:

Tuberculosis is an ancient infectious disease that remains one of the major global health problems.
Until now, effective, convenient, and affordable methods for diagnosis of PTB were still lacking.

Objective:

This study focused on constructing a label-free LC-MS/MS-based comparative proteomics
between six tuberculosis patients and six healthy controls to identify Differentially Expressed Proteins
(DEPs) in plasma.

Methods:

To reduce the influences of high-abundant proteins, albumin and globulin were removed from
plasma samples using affinity gels. Then DEPs from the plasma samples were identified using a label-free
Quadrupole-Orbitrap LC-MS/MS system. The results were analyzed by the protein database search algorithm
SEQUEST-HT to identify mass spectra to peptides. The predictive abilities of combinations of host
markers were investigated by General Discriminant Analysis (GDA), with Leave-One-Out Cross-
Validation (LOOCV).

Results:

A total of 572 proteins were identified and 549 proteins were quantified. The threshold for
DEPs was set as adjusted p-value < 0.05 and fold change ≥1.5 or ≤0.6667, 32 DEPs were found. ClusterVis,
TBtools, and STRING were used to find new potential biomarkers of PTB. Six proteins, LY6D,
DSC3, CDSN, FABP5, SERPINB12, and SLURP1, which performed well in the LOOCV method validation,
were termed as potential biomarkers. The percentage of cross-validated grouped cases correctly
classified and original grouped cases correctly classified is greater than or equal to 91.7%.

Conclusion:

We successfully identified five candidate biomarkers for immunodiagnosis of PTB in
plasma, LY6D, DSC3, CDSN, SERPINB12, and SLURP1. Our work supported this group of proteins
as potential biomarkers for PTB, and be worthy of further validation.
Revision of the Regioselectivity of the Beirut Reaction of Monosubstituted Benzofuroxans with Benzoylacetonitrile. 6-Substituted quinoxaline-2-carbonitrile 1,4- dioxides: Structural Characterization and Estimation of Anticancer Activity and Hypoxia Selectivity
Authors: Buravchenko Galina I. , Scherbakov Alexander M. , Korlukov Alexander А. , Dorovatovskii Pavel V. , Shchekotikhin Andrey E.
Published: December 2019

Background:

Quinoxaline 1,4-dioxides have a broad range of biological activity that causes a
growing interest in their derivatives for drug discovery. Recent studies demonstrated that quinoxaline 1,4-
dioxides have a promising anticancer activity and good hypoxia-selectivity.

Objective:

The preparation, isolation, structure characterization, and screening for anticancer activity of the
first representatives of 6-substituted quinoxaline-2-carbonitrile 1,4-dioxides have been described.

Material and Method:

A series of 7- and 6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides was
synthesized by the Beirut reaction. The cytotoxicity was assessed by MTT test (72 h incubation) in normoxia
(21% O2) and hypoxia (1% O2) conditions.

Results:

We found that during the Beirut reaction between a benzofuroxan bearing an electron withdrawing
group and benzoylacetonitrile in the presence of triethylamine, in addition to well-known 7-substituted
quinoxaline-2-carbonitrile 1,4-dioxides 7-11a, the 6-isomers 7-11b are formed. Moreover, the yield of the 6-
isomers increased with the increase in the electron-withdrawing character of the substituent. For benzofuroxans
with CO2Me and CF3 groups, 6-substituted quinoxaline-2-carbonitrile 1,4-dioxides 10-11b were the major
products. Despite similarities in physicochemical and spectroscopic properties, the obtained isomers exhibit
considerable differences in their anticancer activity and hypoxia selectivity.

Conclusion:

Substituents and their electronic effects play a key role in the formation of 7- and 6-substituted
quinoxaline-2-carbonitrile 1,4-dioxides in the Beirut reaction and in the cytotoxicity properties of the obtained
isomers.
Synthesis of New 4-Chloro-6-Methylpyrimidin-2-yl-Aminophosphonates as Potential DU145 and A549 Cancer Cell Inhibitors
Authors: Reddy Gajjala Raghavendra , Reddy Chinta Raveendra , Reddy Gopireddy Venkata Subba , Rao Pasupuleti Visweswara , Swaminathan Meenakshisundaram , Krishna Balam Satheeh , Reddy Cirandur Suresh
Published: December 2019

:

A series of new α-aminophosphonates containing potential anticancer active 4-chloro-6-
methylpyrimidin-2-amino pharmacophore were synthesized.

Background:

α-Aminophosphonates are of growing interest to the researchers due to their biological
activities. Besides aminophosphoryl functionality, which is responsible for the vital activity, incorporation
of a captivating pharmacophore on it will definitely enrich its activity.

Objective:

Erstwhile many of the reported α-aminophosphonates impregnated with bioactive heterocycles
like quinazoline, chromene, pyrazole, furan and thiophene were used as anticancer drugs, and
we are intended to enhance the anticancer potentiality of α-aminophosphonates by substituting a new
4-chloro-6-methylpyrimidin-2-yl group into its structure, specifically on nitrogen atom.

Methods:

Title compounds were synthesized by Kabachnik-Fields reaction by using sulfated Titania,
a solid acid catalyst that is encompassed with high density of Lewis acidic reaction sites. The series
of synthesized compounds were screened for in vitro anti-cancer activity and their ADMET, QSAR
and drug properties studied.

Results:

Structures of all the title compounds synthesized in high yields were confirmed by spectral
& elemental analyses. Their anti-cancer screening studies on various cell lines and evaluation of
other properties revealed their potentiality towards the inhibition of growth of DU145 & A549 cell
lines.

Conclusion:

The substitution of 4-chloro-6-methylpyrimidin-2-amino moiety on to the amino functionality
of the α-aminophosphonates is a critical task invariably due to the substitutions that are
located on α-carbon. As such, this substitution had increased the scope for growth inhibition of
DU145 and A549 cancer cells.
Pengaruh Penambahan Ekstrak Sarang Semut (Myrmecodia sp) Terhadap Bobot Akhir, Persentase Lemak Abdominal dan Hati Ayam Broiler Fase Finisher
Authors: Lisnanti Ertika Fitri , Qowim Nizarul , Fitriyah Nur
Published: December 2019

Penelitian ini mempunyai tujuan untuk mengetahui pengaruh penambahan ekstrak sarang sarang semut (Myrmecodia sp) terhadap bobot akhir, persentase lemak abdominal dan hati ayam broiler fase finisher. Penelitian ini dilaksanakan di laboratorium Peternakan Fakultas Pertanian Universitas Islam Kadiri (UNISKA) dan Laboratorium Kimia Universitas Muhammadiyah Malang (UMM). Metode dalam penelitian ini adalah penelitian eksperimental.menggunakanÂ  rancangan acak lengkap (RAL) dengan 4 perlakuan dan masingmasing perlakuan terdiri dari 5 ulangan, dan setiap petak terdiri dari 4 ekor ayam, total keseluruhan bahan percobaan 80 ekor ayam. Data penelitian dianalisis secara statistik menggunakan analisa ragam dengan uji F. Hasil analisis statistik dari penambahan ekstrak sarang semut (Myrmecodia sp) dengan dosis 5 mg/kg bb, 10 mg/kg bb, dan 15 mg/kg bb tidak memberikan pengaruh yang nyata (P>0,05) terhadap bobot akhir, persentase lemak abdominal dan hati ayam broiler. Rataan bobot akhir berkisar antara 1495,95-1518,55 (g), dan berat lemak abdominal ayam broiler berkisar antara 12.51 â€“ 14.99 gram atau 0.82% -1.00% dari berat badan. Sedangkan berat hati yang dihasilkan berkisar antara 38,15 â€“ 38,90 gram atau 2,51 â€“ 2,60 % dari berat badan, dan hasil ini menunjukkan bahwa bobot akhir,Â  persentase lemak abdominal dan hati ayam broiler masih taraf normal. Disarankan untuk dilakukan penelitian lebih lanjut dan lama penggunaan ekstrak sarang semut (Myrmecodia sp) pada perlakuan.
15 anos do Estatuto do Idoso e a importância da aplicabilidade do procedimento e dos institutos despenalizadores previstos na Lei 9.099/1995 aos crimes cometidos contra a pessoa idosa
Authors: Silva Christina Celina Schultz da
Published: December 2019

Este artigo analisa a importância dos julgados que possibilitaram a aplicação do procedimento e dos institutos despenalizadores previstos na Lei n. 9.099/1995 aos crimes praticados contra a pessoa idosa. A pesquisa foi realizada por meio do método dedutivo e revisão bibliográfica. Inicialmente, far-se-á uma pequena incursão pelos principais entendimentos doutrinários acerca da aplicabilidade de tais procedimentos e institutos aos crimes praticados contra a pessoa idosa. Conclui-se o estudo com o enfoque adotado pelo julgamento do Supremo Tribunal Federal na Ação Direta de Inconstitucionalidade n. 3096.
The Personal Health Network Mobile App for Chemotherapy Care Coordination: Qualitative Evaluation of a Randomized Clinical Trial (Preprint)
Authors: Ngo Victoria , Matsumoto Cynthia G , Joseph Jill G , Bell Janice F , Bold Richard J , Davis Andra , Reed Sarah C , Kim Katherine K
Published: December 2019

BACKGROUND

Cancer care coordination addresses the fragmented and inefficient care of individuals with complex care needs. The complexity of care coordination can be aided by innovative technology. Few examples of information technology-enabled care coordination exist beyond the conventional telephone follow-up. For this study, we implemented a custom-designed app, the Personal Health Network (PHN)—a Health Insurance Portability and Accountability Act-compliant social network built around a patient to enable patient-centered health and health care activities in collaboration with clinicians, care team members, caregivers, and others designated by the patient. The app facilitates a care coordination intervention for patients undergoing chemotherapy.

OBJECTIVE

This study aimed to understand patient experiences with PHN technology and assess their perspectives on the usability and usefulness of PHNs with care coordination during chemotherapy.

METHODS

A two-arm randomized clinical trial was conducted to compare the PHN and care coordination with care coordination alone over a 6-month period beginning with the initiation of chemotherapy. A semistructured interview guide was constructed based on a theoretical framework of technology acceptance addressing usefulness, usability, and the context of use of the technology within the participant’s life and health care setting. All participants in the intervention arm were interviewed on completion of the study. Interviews were recorded and transcribed verbatim. A summative thematic analysis was completed for the transcribed interviews. Features of the app were also evaluated.

RESULTS

A total of 27 interviews were completed. The resulting themes included the care coordinator as a partner in care, learning while sick, comparison of other technology to make sense of the PHN, communication, learning, usability, and usefulness. Users expressed that the nurse care coordinators were beneficial to them because they helped them stay connected to the care team and answered their questions. They shared that the mobile app gave them access to the health information they were seeking. Users expressed that the mobile app would be more useful if it was fully integrated with the electronic health record.

CONCLUSIONS

The findings highlight the value of care coordination from the perspectives of cancer patients undergoing chemotherapy and the important role of technology, such as the PHN, in enhancing this process by facilitating better communication and access to information regarding their illness.
The Language of the Ukrainian National Minority as an Element of Media Propaganda
Authors: Ertanowska Delfina
Published: December 2019

The article deals with the issue of the language of the Ukrainian national minority as a tool in Russian media propaganda. The impact of media manipulation of the Ukrainian language for the formation of the concept of nationality and self-identification among Ukrainian national minorities living in Central Europe has been approximated.
ТРАНСПОРТ ПРИБЛИЖАЕТСЯ К ЦИФРОВОЙ ЭРЕ
Authors: Сергеев П.
Published: December 2019

Транспорт – одна из отраслей, где цифровизация и, в частности, технологии 5G могут принести серьезный эффект. В этом можно было убедиться на организованном Ассоциацией "Цифровая Эра Транспорта" форуме "Интеллектуальные транспортные системы России", который прошел в российской столице 25–26 сентября в четвертый раз. Форум, включающий с 2017 года и региональную составляющую, стал ключевой площадкой в стране, которая традиционно собирает заказчиков и поставщиков решений в сфере цифровых технологий на транспорте, предоставляет возможности для дискуссий, обмена опытом и консолидации усилий.
ВОЛОКОННАЯ КОНФЕРЕНЦИЯ ПАМЯТИ АКАДЕМИКА Е.М.ДИАНОВА
Authors: Набоких Л. , Попов С.
Published: December 2019

В октябре каждого нечетного года местом неодолимого притяжения для ведущих ученых и специалистов – волоконных оптиков, становится столица Западного Урала. В нынешнем году 7-я Всероссийская конференция по волоконной оптике была посвящена памяти основателя и бессменного председателя программного комитета ВКВО академика Евгения Михайловича Дианова, выдающегося ученого в области волоконной оптики, лазерной физики и оптического материаловедения, создателя Научного центра волоконной оптики Российской академии наук.
СИСТЕМЫ ЕДИНОГО ВРЕМЕНИ: ПРИЧИНЫ ВОЗНИКНОВЕНИЯ ОШИБОК ПРИ ДЛИТЕЛЬНОМ ИСПОЛЬЗОВАНИИ АППАРАТУРЫ И ИХ УСТРАНЕНИЕ
Authors: Маслова О. , Лаврентьева Л.
Published: December 2019

Оптимизация процедур передачи сигналов времени и их привязки к системе единого времени в немалой степени связана с решением проблемы ошибок временной привязки при длительном использовании аппаратуры. Применение новых способов коррекции ошибок позволяет уменьшить погрешности сигналов времени до десятков наносекунд, обеспечивая более высокие точности измерений различных измерительных средств.
КОРПОРАТИВНАЯ СЕТЬ LTE В РЮКЗАКЕ, ЧЕМОДАНЕ, МАШИНЕ
Authors: Павлова Л.
Published: December 2019

Компании Iskratel и Athonet вывели на рынок совместные решения для создания корпоративных сетей LTE и 5G. Среди них – PriMo Rucksack в портативном корпусе, LTE Bundle Kit в чемодане и др. К опорным сетям операторов связи они могут быть подключены любым доступным способом.
Análisis de la presencia digital de los candidatos presidenciales de 2012 en Facebook
Authors: Espino Sánchez Germán , Martínez Rivera Tania Esmeralda
Published: December 2019

En este artículo se presenta un estudio de caso sobre el uso de Facebook en las campañas de los principales candidatos a la Presidencia de México en 2012. Se realizó un análisis de contenido de las publicaciones en Facebook de los candidatos y un análisis automatizado de las interacciones a partir de los botones sociales (“Me gusta”, “Compartir” y “Comentar”) de esta plataforma. Las campañas usaron la red Facebook con fines propagandísticos, no para dialogar y colaborar con los usuarios de Internet; fueron campañas de videopolítica más que de cultura o participación y convergencia
Meaning Variations of Qāla (قال) in Indonesian Language
Authors: Nikmah Khoirin
Published: December 2019

One of main component for every language is verb. In Arabic, qāla (قال) is one of verbs which substantively is used in many oral and written language due to its wide meaning. This research focuses on meaning variation of qāla (قال) when it was translated into Indonesian. In this study, differential meaning can be caused by differential speaker and also differential context. Thereby, the research aims to classify and explain every single meaning of qāla (قال) verb. This descriptive qualitative research uses observation method with tapping technique. Meanwhile, the data was analyzed by translational method, referential method, and pragmatics method. The result of the research shows that; (1) There are three differential meanings of qāla (قال) according to speaker perspective, as well as ‘berfirman’, ‘bersabda’, and ‘berkata’. (2) There are some differential meanings of qāla (قال) according to linguistics perspective, such as ‘berkata, mengatakan, mengabarkan, mengumumkan, berbicara, mengucapkan, mengaku, pendapat, bertanya, menjawab, perintah, and berdoa.
Biology of Shortfin Mako Shark (Isurus oxyrinchus Rafinesque, 1810) from the Eastern Mediterranean
Authors: Bengil Elizabeth Grace Tunka , Akalın Meryem , Tüney Kızılkaya İnci , Bengil Fethi
Published: December 2019

Shortfin mako, Isurus oxyrinchus Rafinesque, 1810, is one of the commercially
and recreationally important shark species in the world. Still knowledge on its
biology and status is limited in the eastern Mediterranean. Three individuals
were caught from Turkish waters. Two individuals (one female and one male) stomach
contents, morphological measurements and female’ gonad histology were studied. According
to the results from macroscopic examination and gonad histology, the female was
a Stage 1-immature, and smallest female ever recorded from Turkish waters. In addition,
phylogenetic network of mitochondrial haplotypes was constructed for all three
individuals. The phylogenetic network analysis supported that the species
having a metapopulation as mentioned in previous studies. Since every
information is critical for development of conservation actions aiming
endangered species, we believe that our study will contribute to the limited
knowledge on I. oxyrinchus biology and reproduction habits in Eastern
Mediterranean.
Design of a novel chiral fractal resonator
Authors: Mezache Zinelabiddine , Zara Chemseddine , Benabdelaziz Fatiha
Published: December 2019

In this paper, we presented a compact resonator using a planar chiral fractal
tree structure, where the chirality and the fractal form can combine several
features at once. The chiral properties of this resonator, which are
discussed based on their optical activity, circular dichroism, and the
effect of the number of the iteration. Our chiral fractal structure is of
major interest in scientific research, their characteristics have given rise
to interesting new applications. Numerical results are given and discussed
to confirm.
Model for speech signal quality estimation in packet network of electricity supply industry
Authors: Lebl Aleksandar , Mitic Dragan , Matic Vladimir , Markov Zarko
Published: December 2019

In this paper we present the dilemma dealing with the choice of speech
segment duration and the calculation of speech signal quality in the packet
telephone network of Electricity supply industry (ESI). The analyzed signal
is packetized by one packet. The characteristic of this network is that
disturbances of long duration in power system produce burst packet loss. The
longer speech segments increase the packet delay, but decrease the number of
lost packets in one burst, and vice versa. Here we present why it is better
to choose speech segments of short duration. Also, we suggest the corrected
method for the calculation of speech signal quality in packet network under
the influence of long duration disturbances.
A Clarice de Benjamim Moser: uma "evidência folclórica"
Authors: Jeronimo Thiago Cavalcante
Published: December 2019

Este artigo apresenta posicionamentos críticos acerca dos escritos de Benjamin Moser. Para tanto, apoia-se, sobretudo, nas contribuições de Benjamin Abdala Júnior sobre as coincidências e os equívocos que o norte-americano apregoa na biografia Clarice, (lê-se “Clarice vírgula”), nas inferências de Márcia Lígia Guidin a respeito do relançamento da biografia escrita pelo biógrafo pelo selo da Companhia das Letras e, ainda, na pesquisa de Breno Couto Kümmel e Ludimila Moreira Menezes no tocante à introdução que Moser faz à publicação da obra Crônica da casa assassinada, de Lúcio Cardoso, nos Estados Unidos. Busca-se, pautando-se pelos pronunciamentos dos críticos supramencionados, averiguar nas publicações do norte-americano um discurso marcado por elementos antiéticos e da ordem da ilegitimidade.
“Colagem de impossibilidades”: os desenlaces da tradução
Authors: Lanius Marcela
Published: December 2019

O presente artigo delimita uma breve cronologia das traduções de Clarice para o inglês e retoma alguns conceitos dos Estudos da Tradução – sobretudo as noções de estrangeirização e domesticação – para discutir as duas versões existentes em língua inglesa de A paixão segundo G.H. (1964) e comentar as diferentes identidades autorais de Clarice Lispector construídas dentro do sistema anglófono. A partir dessa discussão, o artigo propõe uma leitura de duas obras autorais de Idra Novey, tradutora da segunda e mais recente tradução de G.H., para avaliar as tensões entre escrita autoral e escrita tradutora.
Literatura de infância: a fábula infantil
Authors: Palo Maria José
Published: December 2019

Este estudo é atribuído ao tema Literatura de Infância, que aborda a fábula como a fundação do gênero infantil, e o fenômeno da palavra infantil como sua auto referência. A introdução da voz infantil no sistema de signos da língua faz da fábula a sua história na experiência de linguagem. O objetivo é situar a Voz como ponto originário da Infância da linguagem e da Ética, segundo a Teoria da Infância, de Giorgio Agamben, como meio e modo de pensá-la além da mística silenciosa que tem justificado o tempo histórico do elemento maravilhoso aplicado à narratividade infantil. A fábula infantil faz-se experiência no interior da língua de criança, algo que só a linguagem poética sustenta sob a lei da semelhança, segundo Walter Benjamin. O hiato entre a língua e a fala gera a diferença e o descontínuo do espaço em que a Voz infantil ganha a compreensão de "ser signo".
A alteridade construída na ruptura e na transgressão
Authors: Alfeld Elisabete
Published: December 2019

A proposta do estudo é evidenciar  na construção do enredo do filme A forma da água(Del Toro, 2017) a interface fabulação/alteridade. Para isso, organizamos o texto em dois momentos: no primeiro, centramos na criação da fábula e na linguagem audiovisual; no segundo, abordamos a alteridade. O corpus teórico prioriza Blanchot (2010; 2011), Bachelard (1997), Agamben (2009), Deleuze (1997) e Lévinas (1989; 1997). Os aspectos destacados na análise referem-se à: representação do imaginário, metaforização da água; alteridade.
LUDWIG, Ken. How to teach your children Shakespeare. New York: Broadway Books, 2013. 350 p.
Authors: De Souza Valle Neto Júlio
Published: December 2019

Resenha do livro citado no título.
A escrita (do) impossível em A hora da Estrela
Authors: Rosenbaum Yudith
Published: December 2019

Esse artigo propõe-se  a discutir  os embates narrativos entre o narrador Rodrigo  S.M e a personagem Macabéa, no romance A hora da estrela, de Clarice Lispector, à luz de uma fundante impossibilidade que rondaria a obra: como dar forma a um ser impossível de ser apreendido pelas palavras? O acesso à Macabéa  se mostra opaco e problemático, do mesmo modo que o próprio narrador se desconhece no processo de desvendar este outro esquivo. A partir dessa premissa, pretende-se observar o jogo em que se movem  narrador,  personagem, escritora e leitor. A "delicada e vaga existência de Macabéa", nas palavras do narrador, acaba por desafiar uma escrita dividida entre o imperativo da expressão verbal e a carência da linguagem. O que resta desse conflito entre o objeto provocativo da escritura e a dificuldade em dizê-lo é, paradoxalmente, um excesso de indagações, hesitações e peripécias narrativas. A presente leitura convoca noções psicanalíticas para compreender algumas faces deste vasto campo de sentidos.
A transgressão do discurso hegemônico da imprensa feminina nas colunas de Tereza Quadros, máscara de Clarice Lispector
Authors: Sandroni Tânia
Published: December 2019

Em 1952, Clarice Lispector produziu, sob a máscara de Tereza Quadros, a página  “Entre mulheres” no jornal Comício, dirigido por Rubem Braga, Joel Silveira e Rafael Correa de Oliveira. A coluna trazia à leitora, ao lado de receitas e orientações domésticas (comuns na imprensa feminina), textos de outros autores (muitos deles citados no livro O segundo sexo, de Simone de Beauvoir, ainda inédito no Brasil) e crônicas com temas e figuras clariceanos. Dessa forma, a página de Tereza Quadros não se constituía como um espaço modelador do estereótipo feminino, pois subvertia o discurso hegemônico da imprensa destinada a esse público  apresentando questionamentos sobre o papel e o comportamento das mulheres.
Ética en tiempos de corrupción
Authors: Herrera Diego , Troya Carlos
Published: December 2019

Una paciente joven sufre un trauma en la pierna, como consecuencia de esto, presenta una fisura en el peroné, acude al sistema público donde un ortopedista le sugiere operarse en una clínica privada por 1500 dólares, aduciendo las deficiencias de insumos en el sistema público. Enojada ante este chantaje, solicita al administrador de turno una cita con otro especialista, luego de tres horas el nuevo médico le recibe con la frase,” ¿usted es la que no quiere pagar 1500 dólares para sanarse?........al final la cirugía no era necesaria.