bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor necrosis factor receptor-associated factor 5 enhances perianal fistulizing Crohn’s disease through epithelial–mesenchymal transition
Authors: Sun Xiaomei , Gao Hairui , Lu Lu , Wang Qianqian , Li Youran , Gu Yunfei
Published: December 2024

Objective:

Crohn’s disease (CD) is a chronic inflammatory condition of the bowel that remarkably impairs a patient’s quality of life and often has a poor prognosis. Perianal fistulizing CD (PFCD) is one of the most common parenteral symptoms of CD and a huge challenge for the management of this illness. This study aimed to elucidate the molecular mechanisms underlying PFCD and identify potential biomarkers to advance our understanding and management of this condition.

Material and Methods:

Transcriptome sequencing was performed using the control and PFCD groups to investigate the mechanisms of PFCD development. The expression of tumor necrosis factor receptor-associated factor 5 (TRAF5), nuclear factor-kappa B (NF-κB), and interleukin 13 (IL-13) messenger ribonucleic acid (mRNAs) was detected by quantitative polymerase chain reaction (qPCR). Pathological morphology was observed using hematoxylin and eosin staining. The expression of TRAF5, Epithelial Cadherin (E-cadherin), Snail family transcriptional repressor 1 (SNAIL1), and vimentin protein was detected by immunohistochemistry. Following the knockdown of TRAF5 in human tumor-29 (HT-29) cells, the effects on cell proliferation and migration were assessed using the cell counting kit-8 and Transwell assays. The expression levels of crucial markers were analyzed by qPCR, Western blot, and immunohistochemistry.

Results:

Transcriptomic sequencing revealed a significant upregulation of TRAF5 in the PFCD group, accompanied by elevated mRNA levels of NF-κB and IL-13 compared with those in the control group. In addition, the PFCD group exhibited increased expression of TRAF5, SNAIL, and vimentin and marked reduction in E-cadherin levels, indicating that PFCD may facilitate epithelial–mesenchymal transition (EMT). Knocking down TRAF5 in HT-29 cells reduced cell proliferation and migration; inhibited NF-κB and IL-13 mRNAs, SNAIL1, and vimentin levels; and promoted E-cadherin levels.

Conclusions:

The development of PFCD was associated with EMT, and TRAF5 was a key gene of PFCD. Knocking down TRAF5 alleviated the EMT promotion of PFCD, indicating that TRAF5 drove the development of PFCD through EMT.
FTO-mediated regulation of Kupffer cell polarization and interleukin-6 secretion promotes biliary epithelial cell proliferation in intrahepatic bile duct stones
Authors: Li Lixiang , Peng Hui , Li Ziyi , Zhou Fuhai , Yu Qingsheng
Published: December 2024

Objective:

Intrahepatic cholangiolithiasis (Intrahepatic bile duct stones, IBDSs) is a common hepatobiliary disease characterized by bile duct obstruction and inflammation, often leading to severe complications such as cholangitis, cirrhosis, and cholangiocarcinoma. This study investigates the role of fat mass and obesity-associated (FTO) protein, an RNA demethylase, in regulating Kupffer cell (KC) polarization, interleukin (IL)-6 secretion, and subsequent human intrahepatic biliary epithelial cell (HiBEC) proliferation in IBDS.

Material and Methods:

Liver tissues from patients with IBDS were analyzed for FTO expression, KC M2 polarization, and IL-6 levels. In vitro experiments with FTO silencing in KCs were conducted to examine the effects on M2 polarization, IL-6 production, and HiBEC proliferation. Mechanistic analysis focused on the c-Jun N-terminal kinase (JNK)/p38 and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathways.

Results:

The patients with IBDS showed significantly higher KC M2 polarization, elevated FTO expression, and increased IL-6 levels relative to the controls. Without FTO silencing, IL-6 secretion and HiBEC proliferation remained at high baseline levels. However, FTO silencing reduced M2 polarization, IL-6 secretion, and HiBEC proliferation through the JNK/p38 pathway. Activating the PI3K/AKT pathway partially reversed these inhibitory effects.

Conclusion:

FTO plays a critical role in IBDS by promoting the M2 polarization of KCs, which leads to increased IL-6 secretion and induced pathological HiBEC proliferation. Targeting FTO may represent a novel therapeutic strategy for managing IBDS and preventing disease progression.
Genital tuberculosis: A silent contributor to infertility and adverse pregnancy outcomes
Authors: Sikenis Mudra , Prajapati Bhavna , Singh Ashutosh Kumar , Yadav Karmveer , Rahman Akhlaqur , Pandey Megha Katare , Nema Ram Kumar
Published: December 2024

Genital tuberculosis (GTB) is a significant yet often unnoticed reason for infertility, disproportionately affecting women in areas with a high burden of tuberculosis (TB). Notwithstanding its considerable effect on reproductive health, GTB remains underdiagnosed due to its inconspicuous clinical presentation and the limits of existing diagnostic tools. This review gives a top-to-bottom examination of the epidemiological patterns and physiological impacts of GTB, featuring the intricate interchange between illness and infertility. The discussion envelops the complex difficulties in diagnosing GTB-associated infertility, which incorporate the nonspecific symptoms, the absence of delicate and explicit diagnostic tests, and the potential for misdiagnosis with other gynecological conditions. Furthermore, we investigate the ongoing pharmacological medications used to treat GTB, focusing on their efficacy, limitations, and the emergence of drug-resistant TB strains that complicate treatment outcomes.
الخدمات البنكية الإلكترونية وسائلها وأحكامها الفقهية
Authors: محمد عبداللطيف الخيالي
Published: December 2024

يهدف البحث إلى تعريف الخدمات البنكية الإلكترونية، التي أصبحت مهمة في حياتنا، ومعرفة وسائلها وأحكامها الفقهية. واعتمد الباحث المنهجين التاريخي والوصفي التحليلي في هذا البحث، الذي ينتمي إلى مجال العلوم الشرعية المتعلقة بفقه المعاملات المصرفية الإلكترونية، وقد قسمه إلى ثلاثة مباحث، المبحث الأول تناول الصيرفة الإلكترونية من حيث النشأة والمفهوم والمزايا والوسائل، بينما في المبحث الثاني تم التعرف على بطاقات الائتمان، أما المبحث الثالث فخصص للأحكام الفقهية لبعض الخدمات البنكية الإلكترونية. ومن بين نتائج هذا البحث: أن الخدمات البنكية الإلكترونية هي الخدمات التي تقدمها البنوك اعتمادا على وسائط إلكترونية، من ذلك بطاقة الائتمان، وقد أجازت الهيئات الشرعية من هذه الخدمات ما كان متوافقا مع أحكام الشريعة ولا يتضمن محظورا شرعيا.
أحاديث القيام للجنازة بين المحدثين والفقهاء دراسة تطبيقية من كتاب (سنن أبي داود السجستاني)
Authors: أبو فطيم عبدالله سالم
Published: December 2024

تناول البحث دراسة الأحاديث التي أوردها الإمام أبو داود سليمان بن الأشعث السجستاني في كتابه (السنن)، في مسألة القيام للجنازة، وقام الباحث بدراستها حديثياً وفقهياً.  وهدف البحث إلى بيان مدى الحاجة للاختلاف في مسألة القيام للجنازة، ودراسة تعارض ظواهر الأحاديث في القيام لها، مع ذكر الفرق في المتبع المشيع للجنازة، والجالس التي مرت به، ثم توضيح علة القيام للجنازة التي دار عليها الحكم، وبيان الحكم الشرعي لها. وإن ما تحقق من نتائج للباحث في نهاية بحثه: اعتبار مسألة القيام للجنازة إحدى المسائل التي يسوغ الاختلاف في حكمها، وعلتها لتعارض ظواهر أدلتها، وما كان من الأحاديث الدالة على القعود منه –صلى الله عليه وآله وسلم- ومخالفته لليهود فيما اعتادوه من قيام للجنائز.. يُرجّح القول بكراهة القيام للجنازة مطلقاً. وأن من كان سائراً متبعاً للجنازة يُكره منه الجلوس حتى توضع على الأرض عن الأعناق.
مَقْصد سَتْر المرأة وصيانتها، وأثره في أحكام الحج (أنموذجًا)
Authors: نور نجلاء محمد برهان محمد , المقبل ندى تركي
Published: December 2024

يهدف البحث إلى الكشف عن مقصد ستر المرأة وصيانتها وأثره في أحكام الحج، عن طريق جمع الفروع الفقهية المتأثرة به، ودراستها دراسة فقهية مقارنة، ومن ثم بيان أثر المقصد من خلال استقراء نصوص الفقهاء المتعلقة بالمقصد في تلك الفروع، واستنباط أنواع ذلك الأثر وتحديد حجمه وضوابطه، لإثبات مقاصديته وتأكيدها، وقد تناولت ذلك من خلال التأصيل لمقصد ستر المرأة وصيانتها ابتداء، ومن ثم تحديد أثر المقصد وضبطه من خلال آراء العلماء في الفروع والمسائل الفقهية المتعلقة به في أحكام الحج ودراستها دراسة فقهية مقارنة، ومناقشتها والترجيح بينها، وقد ظهر من خلال ذلك التنوع في أثره في تلك الأحكام، فهو دليل مستقل بذاته في كثير منها، وهو أيضا حكمة للدليل، وغير ذلك، مما يؤكد ويثبت كونه مقصدا شرعيا، تعتبره الشريعة وتراعيه في أحكام المرأة وأحوالها عموما، كما اعتبرته في أحكام الحج المتعلقة بها خصوصا.
العقل ودوره في العلوم الشرعية: دراسة تأصيلية مقارنة
Authors: شرمند محمد مصطفى
Published: December 2024

هذه دراسة تأصيلية لمفهوم العقل في الإسلام، وإبراز ما إذا كان له دور فيه، بالمقارنة مع من اعتنى بهذا المفهوم عند أهل العلم. انتهجَتْ منهج التحليل والتأصيل والمقارنة، معتمدةً على أمهات المصادر في هذا الشأن، ليظهر من خلال الدراسة آلية عمل العقل في العلم الشرعي، لا سيما في علمي أصول الدين وأصول الفقه، فهما العلمان اللذان يُعنيان بالمنهج العلمي الإسلامي. كما تهدف الدراسة إلى تبيان مكانة العقل في الاستدلال ومدى حجيته في التشريع، متوخية الدقة والموضوعية. فإن غاية هذه الدراسة هي الخروج من العباءة التقليدية -النصوصية- التي وُسم فيها العلم الشرعي، ليُعمل أهل العلم وطلبته عقولهم فيه، فيكملوا ما بدأه أسلافهم من إذخار المعرفة وإثرائها، وذلك بإعادة النظر فيما وُضع بين أيديهم من التراث الإسلامي، ومعرفة أنه متقدم وعليه سمة العبقرية، وليس رجعياً أو جامداً.
Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes
Authors: Xu Jiaming , Adepoju Stephen , Pandey Simran , Pérez Tetuán Jimena , Williams Mary , Abdelmessih Rudolf , Auguste Debra , Hung Francisco
Published: December 2024

We performed all-atom and coarse-grained simulations of lipid bilayers mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus KA ~22% smaller than the pure DOPC value. Raising the mole% of DOPC leads to increases in KA, yet at any given composition the KA trend is DSPG < DSPA < DSPS < DSPC < DSPE. Lipid-lipid interactions are weaker in DOPC:DSPG mixtures and stronger in DSPE systems. The head and phosphate groups of the secondary lipids DSPG, DSPA and DSPS interact strongly with salt ions. Adding secondary lipids lead to DOPC having more ordered acyl tails relative to pure DOPC systems. No evidence of phase separation or inhomogeneities was observed in our simulations. We synthesized three liposomal formulations, L-DOPC (pure DOPC), and L-DOPC/DSPG and L-DOPC/DSPA, both with 15 mol% of secondary lipid. L-DOPC/DSPA had approximately 3- and 2-times higher in vitro internalization by normal epithelial (EpH4-Ev) and metastatic breast cancer (4T1) cells, compared with L-DOPC. The uptake of L-DOPC/DSPG by EpH4-Ev cells was almost 2-fold compared to L-DOPC, but both liposomes had similar uptakes by cancer cells. As L-DOPC/DSPG and L-DOPC/DSPA have similar KA values, we presumed that the mechanical properties, possibly in combination with higher negative surface charges in L-DOPC/DSPA and differences in effective liposome diameters and diffusivities, contributed to these observations.
Dissecting the Molecular Structure of the Air/Ice Interface from Quantum Simulations of the Sum-Frequency Generation Spectrum
Authors: Rashmi Richa , Paesani Francesco
Published: December 2024

Ice interfaces are pivotal in mediating key chemical and physical processes, such as heterogeneous chemical reactions in the environment, ice nucleation, and cloud microphysics. At the ice surface, water molecules form a quasi-liquid layer (QLL) with distinct properties from the bulk. Despite numerous experimental and theoretical studies, the molecular-level understanding of the QLL has remained elusive. In this work, we use state-of-the-art quantum dynamics simulations with a realistic data-driven many-body potential to dissect the vibrational sum-frequency generation (vSFG) spectrum of the air/ice interface in terms of contributions arising from individual molecular layers, orientations, and hydrogen-bonding topologies that determine the QLL properties. The agreement between experimental and simulated spectra provides a realistic molecular picture of the evolution of the QLL as a function of temperature without the need for empirical adjustments. The emergence of specific features in the experimental vSFG spectrum suggests that surface restructuring may occur at lower temperatures. This work not only underscores the critical role of many-body interactions and nuclear quantum effects in understanding ice surfaces but also provides a definitive molecular-level picture of the QLL, which plays a central role in multiphase and heterogeneous processes of relevance to a range of fields, including atmospheric chemistry, cryopreservation, and materials science.
Radical borylation of aryl sulfones with 1,3-dimethylimidazol-2-ylidene borane leading to aryl boranes
Authors: Komatsu Ryo , Morioka Tsubasa , Kamimura Akio , Matsubara Hiroshi , Curran Dennis P. , Kawamoto Takuji
Published: December 2024

We have found that aryl boranes can be obtained from aryl sulfones, including phenyl methyl sulfone, 1,3-dimethylimidazol-2-ylidene borane (diMeImd-BH3) in the presence of a radical initiator. The reaction proceeds via the addition of a boryl radical to an aryl sulfone, followed by β-cleavage to give an aryl borane and a sulfonyl radical. The generated aryl boranes can be applied for Suzuki-Miyaura coupling with 4-bromophenyl methyl sulfone.
Management of ankyloglossia (tongue tie)-A Case Series
Authors: Koti Ashwini , . Rathnashree , Naz Sadiya , Vardhana Bharath , Subramaniam Priya
Published: December 2024

Ankyloglossia commonly referred to as tongue-tie is a condition caused by a short and thick lingual frenulum leading to restricted tongue movement. This limitation can result in functional complications such as abnormal speech malocclusion midline diastema mandibular lingual gingival recession and difficulty swallowing. These challenges can significantly impact an individuals daily activities and quality of life. In this report treatment was followed by post-operative recall and speech therapy sessions resulting in marked improvement in tongue mobility and speech across all treated cases. Diagnosis was conducted clinically using Kotlowrsquos classification. The findings highlight that the conventional scalpel-based method of frenectomy is relatively painless reliable and effective. Unlike some newer methods this technique consistently ensures successful outcomes reaffirming its value in the management of ankyloglossia.
Digitalization in the Field of Dentistry
Authors: Suchetha A Dr.
Published: December 2024

None
Susaс’s syndrome is an autoimmune inflammatory endotheliopathy at the confluence of neurology, ophthalmology, and otology
Authors: Shulga O.D. , Kotsyuba O.G. , Romaniuk A.S. , Zheshko O.M. , Shulga L.A.
Published: December 2024

Background. Susaс’s syndrome is a rare autoimmune vascular-occlusive disease, which is accompanied by damage to the endothelium of blood vessels by circulating antibodies and leads to multiple microinfarcts. This pathological process is characterized by damage to the small arterial vessels of the central nervous system, retina, and inner ear, which is manifested by the classic triad of the following symptoms: encephalopathy, retinal artery occlusion, and sensorineural hearing loss. In addition, Susaс’s syndrome is characterized not only by the classic triad of symptoms, but also by the classic triad of neuroimaging signs, namely: damage to the white matter of the brain, the presence of foci in the deep structures of the gray matter, and leptomeningeal damage. To date, this disease remains insufficiently studied, and therefore the exact frequency and prevalence of this disease have not been definitively established. This process is complicated by frequent diagnostic errors and cases of incorrect diagnosis. This is due to the fact that in most patients a complete combination of clinical and neuroimaging signs at the onset of the disease is rare, and the symptoms of target organ damage are manifested by variable and non-specific signs.

Purpose – еarly detection and timely adequate treatment of this pathology are key to preventing irreversible damage and improving the prognosis and quality of life of patients. This work is aimed at increasing the vigilance of ophthalmologists, neurologists and otolaryngologists, as specialists who are most often encountered in clinical practice with this syndrome, since Susak’s syndrome requires rapid and aggressive treatment with the use of corticosteroids, intravenous immunoglobulin, and in the case of its fulminant course, the use of monoclonal antibodies and cytostatics.

Materials and Methods. Based on a review of current data on the topic of our study, we analysed the original articles, literature, meta-analyses and book chapters. We used clinical and neurological, biochemical, neuroimaging and audiometric methods of research.

Results. Diagnosis of Susak’s syndrome requires a comprehensive approach, which includes a carefully collected medical history, a qualitative physical examination, as well as additional examination methods such as MRI of the brain, audiometry, and ophthalmological examination.

Conclusions. Despite numerous studies, growing awareness of doctors, progress in diagnosis and treatment, Susak’s syndrome still remains a unique challenge for the attending physician due to nonspecific symptoms, lack of specific diagnostic markers, and universal treatment protocols. That is why vigilance when detecting typical neurological, ophthalmological or otological symptoms and interdisciplinary involvement of specialists of these profiles are so important to improve the results of treatment of such a complex disease.
Enhancing the Quality and Adaptability of Vocational Education to Promote High-Quality Development: Taking Hainan Vocational University of Science and Technology as an Example
Authors: Yan Linyin , Zhang Yu , Yuan Rongping , Zong Xuan
Published: December 2024

This paper aims to explore effective strategies for overcoming the five core challenges currently faced by vocational education: challenges in defining the educational type, variations in the quality of incoming students and their learning abilities, the need to improve teaching quality and effectiveness, urgent requirements for optimizing the quality of teaching staff, and insufficient depth in the integration of industry and education. By analyzing the root causes of these challenges, this paper proposes a series of targeted strategies and measures. Taking the School of Chemistry and Materials Engineering at Hainan Vocational University of Science and Technology as an example, the paper elaborates on how the school has significantly enhanced the adaptability and teaching quality of vocational education through precise positioning of vocational education types, strengthening the construction of teaching staff, optimizing teaching methods and content, and deepening the integration of industry and education. The research results indicate that these initiatives not only effectively address key issues in vocational education but also promote comprehensive improvements in students’ overall qualities and employment competitiveness, providing valuable insights and practical references for advancing the high-quality development of vocational education. Furthermore, by introducing the practice of the School of Chemistry and Materials Engineering at Hainan Vocational University of Science and Technology in tailoring vocational education development to local conditions, this paper validates the reliability and feasibility of the proposed solutions.
Characteristics and Influencing Factors of Self-Advocacy in Young and Middle-Aged Patients with Breast Cancer: A Latent Profile Analysis
Authors: Wang Xinyi , Zhang Shan , Zhang Shaoshun , Bao Yu
Published: December 2024

Objective: To explore the potential categories and influencing factors of self-advocacy in young and middle-aged patients with breast cancer and to provide a theoretical basis for personalized intervention. Methods: From September 2023 to March 2024, 314 young and middle-aged breast cancer patients were studied. Female cancer patients were surveyed using the self-advocacy scale, social support rating scale, and chronic health literacy scale. Latent profile analysis was used to investigate the heterogeneity and influencing factors of self-advocacy. Results: Self-advocacy among young and middle-aged breast cancer patients were classified into two potential categories: low advocacy-lack of support (51.7%) and high advocacy-effective communication (48.3%). Binary logistic regression analysis indicated that educational level, per capita monthly income, social support, and health literacy were significant influencing factors of these categories (P < 0.05). Conclusion: Self-advocacy in young and middle-aged breast cancer patients demonstrates categorical heterogeneity. Identifying self-advocacy characteristics and implementing targeted intervention strategies—focused on self-efficacy and improving health literacy—can enhance self-advocacy in these patients.
Hubungan Aktivitas Fisik, Jenis Kelamin dan Usia Terhadap Obesitas Pada Pekerja di Perusahaan Pembangkit Listrik
Authors: Rahmawati Titik Dwi , Inayah Zufra
Published: December 2024

AbstrakLatar belakang: Obesitas merupakan kondisi kelebihan akumulasi lemak pada jaringan adiposa tubuh yang dapat dipengaruhi oleh aktivitas fisik, usia dan jenis kelamin. Angka kejadian obesitas di Indonesia cenderung meningkat dilihat dari data Riskesdas tahun 2007, 2013, dan 2018, yaitu 10,5%, 14,8%, dan 21,8%. Tujuan penelitian untuk mengetahui hubungan tingkat aktivitas fisik, jenis kelamin, dan usia terhadap kejadian obesitas. Metode: Jenis penelitian termasuk penelitian kuantitatif dengan pendekatan cross sectional. Pengumpulan data dilakukan melalui kuesioner. Jumlah sampel dalam penelitian ini terdiri dari 80 orang yang mengalami overweight dan obesitas. Analisis data yang dilakukan yaitu analisis univariat dan bivariat dengan menggunakan uji chi-square. Hasil: Sebesar 36,6% responden overweight dan 63,8% obesitas. Sebagian besar responden berusia <20 tahun. Hasil penelitian menunjukkan bahwa obesitas berhubungan signifikan dengan aktivitas fisik (p =0,025), jenis kelamin (p =0,010), dan usia (p =0,016). Kesimpulan: Hasil uji Chi-Square menunjukkan terdapat hubungan signifikan antara tingkat aktivitas fisik, jenis kelamin, dan usia.
The Narrative of Crime in Andrea Hirata's Novel 'Orang-Orang Biasa': A Formulaic Study
Authors: Sari Hanifah Yulia , Rachman Aditya , Putri Diantri Seprina , Ulya Ridha Hasnul , Widhyah Dhini Yustia
Published: December 2024

The topic of criminality is often viewed as a literary genre closely associated with themes of crime, heroes and anti-heroes, mysterious plots, suspense, plot twists, and violent scenes. This study employs Andrea Hirata's novel "Orang-orang Biasa" as its material object. The data consists of text content in words, phrases, and sentences that align with the predetermined scholarly inquiry. This research uses John G. Cawelti's theoretical framework to delineate data that reveal patterns in narrative structure and character development, thereby classifying the novel as belonging to the crime genre. The findings of this study indicate that the criminal formula presented by Andrea Hirata in "Orang-orang Biasa" is a type of criminal comedy. The results of this study reveal that the formula similarities between Orang-orang Biasaand literary works in the crime genre can be observed in the story motives, setting choices, the presence of additional events accompanying the main narrative, and the characters. The author's presentation of these formulas indicates that the novel belongs to the comedy-crime genre
The Role of Local Customs and Traditions in Maintaining Social Stability: A Case Study of Nubian Weddings in Egypt
Authors: Wicaksono Imam , AlGayyar Sherif Sa’ad , Hassan Ahmed Hassan Mohammad
Published: December 2024

This study intends to evaluate how the wedding traditions of the Nubian community in Egypt preserve cultural identity and sustain social stability in the face of globalization pressures. These traditions encompass rites such as restrictions against marrying non-Nubians, engagement ceremonies, and henna applications, expressing the collective ideals of the community. This study uses a library research method to examine pertinent material using four important functions—adaptation, goal accomplishment, integration, and pattern maintenance—are assessed in the study using Talcott Parsons' AGIL theory. Thematic data from sociological and ethnographic sources pertaining to Nubian cultural activities were analyzed using a literature review methodology. The findings show that the role of adaptation is represented by the prohibition on marriage with non-Nubians, which tries to preserve the integrity of cultural identity. Customary agreements during engagement ceremonies, which improve interfamily connections, demonstrate goal accomplishment. Collective rituals that strengthen community cohesion, like group prayers, are one way that integration is demonstrated. Pattern maintenance is accomplished by symbolic parts of rituals, such as the application of henna, which ensures that traditional values are passed down through generations. These results support the idea that wedding customs serve as a means of maintaining social harmony and cultural continuity in the globalization era
HUBUNGAN TINGKAT KECEMASAN DENGAN FREKUENSI KEKAMBUHAN PASIEN ASMA DI POLI PARU RSUD BENDAN KOTA PEKALONGAN
Authors: Kartikasari Dian , Kanti Tiara Dewi
Published: December 2024

Latar belakang: Asma merupakan penyakit heterogen yang ditandai dengan peradangan saluran napas kronis. Faktor lingkungan yang dapat menyebabkan asma salah satunya adalah kecemasan. Kecemasan dapat meningkatkan eksaserbasi asma dan kecemasan dapat menyebabkan dilepaskannya zat histamin dalam tubuh yang mengakibatkan penyempitan saluran napas dan akhirnya menyebabkan kekambuhan pada pasien asma.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan tingkat kecemasan dengan frekuensi kekambuhan pasien asma di Poli Paru RSUD Bendan Kota Pekalongan.Metode: Penelitian ini merupakan penelitian korelasi dengan pendekatan cross sectional. Teknik pengumpulan data menggunakan accidental sampling. Sampel yang digunakan adalah pasien asma rawat jalan di Poli Paru RSUD Bendan Kota Pekalongan sebanyak 49 responden. Instrumen penelitian ini menggunakan kuesioner HARS (Hamilton Anxiety Rating Scale) dan kuesioner frekuensi kekambuhan. Analisis data yang digunakan yaitu uji spearman.Hasil: Hasil penelitian ini menunjukan 20 responden (40,8%) mengalami tingkat kecemasan berat dan 18 responden (36,7%) mengalami frekuensi kekambuhan dalam kategori presisten berat. Hasil analisis uji spearman menunjukan nilai signifikan 0,001 yang menunjukan (P value< 0,05).Simpulan: Pada penelitian ini dapat disimpulkan ada hubungan tingkat kecemasan dengan frekuensi kekakmbuhan pasien asma di Poli Paru RSUD Bendan Kota Pekalongan. Saran pada penelitian ini yaitu pelayanan kesehatan dapat melakukan pengkajian tingkat kecemasan guna mencegah kekambuhan berulang pada pasien asma.
PERANCANGAN PENDETEKSI BERAT PADA KONVEYOR PENGANGKUT KACANG HIJAU DENGAN METODE VALUE ENGINEERING (VE)
Authors: Warastri Puji , Wibowo Eko Ari , Widyastuti Widyastuti
Published: December 2024

Penelitian ini bertujuan untuk merancang sistem pendeteksi berat pada konveyor pengangkut kacang hijau mengunakan metode Value Engineering dengan sistem Weight Feeder. Sistem ini dirancang untuk meningkatkan efisiensi pengukuran dan mendeteksi kelebihan berat yang menyebabkan kerusakan komponen pada saat proses pemindahan objek. Metode value engineering diterapkan untuk menganalisis fungsi sistem yang ada, mengidentifikasi biaya, dan mengevaluasi alternatif desain yang lebih ekonomis tanpa mengorbankan kualitas. Hasil dari usulan desain menunjukkan bahwa penerapan sistem pendeteksi berat menggunakan sistem Weight Fedeer pada konveyor dapat meningkatkan akurasi pengukuran hingga 99,5% pada kasus proses pemindahan material semen. Berdasarkan sistem yang diterapkan pada konveyor tersebut, konsep yang sama dapat diterapkan untuk penggunaan konveyor pengangkut kacang hijau. Oleh karena itu, penelitian ini merekomendasikan implementasi sistem tersebut pada konveyor yang digunakan untuk mengangkut kacang hijau.
ENDOSCOPIC AND SURGICAL INTERVENTION OF COMPLETE ESOPHAGEAL STRICTURE IN A ONE-MONTH-OLD THOROUGHBRED FOAL WITH Rhodococcus equi PNEUMONIA
Authors: Yoon Jungho , Kim Ahram , Lee Jeonghun , Choi In-Soo , Park Taemook
Published: December 2024

This case report describes a surgical and endoscopic approach for treating a complete esophageal stricture in a one-month-old Thoroughbred foal with Rhodococcus equi pneumonia. Clinical symptoms included coughing, nasal discharge, regurgitation, and lethargy. Endoscopic and ultrasonographic examinations revealed a complete esophageal obstruction caused by soft tissue stricture surrounding the esophageal lumen. The tube esophagostomy, combined anterograde retrograde esophageal assessment, and endoscopic balloon dilation were sequentially applied for the stricture lesion, along with the critical care for the secondary complications. After treatment, the foal was allowed to eat ground feed, chopped hay, and milk, and showed improved vitality. The foal was discharged on post-admission day 35.
Endoskopska in kirurška obravnava popolne strikture požiralnika pri enomesečnem čistokrvnem žrebetu s pljučnico, povzročeno z Rhodococcus equi
Izvleček: V poročilu o primeru je opisana kirurška in endoskopska obravnava popolne strikture požiralnika pri enomesečnem čistokrvnem žrebetu s pljučnico, povzročeno z Rhodococcus equi (Rhodococcus equi pneumonia). Klinični simptomi so bili kašelj, izcedek iz nosu, regurgitacija in letargija. Endoskopska in ultrazvočna preiskava je pokazala popolno obstrukcijo požiralnika, ki jo je povzročila striktura mehkih tkiv okoli lumna požiralnika. Za zdravljenje strikture smo zaporedno izvedli cevno ezofagostomo, kombinirano anterogradno retrogradno oceno požiralnika in endoskopsko balonsko dilatacijo skupaj s kritično oskrbo sekundarnih zapletov. Po zdravljenju je žrebe lahko jedlo mleto krmo, rezano seno in mleko, njegova vitalnost pa se je izboljšala. Žrebe je bilo odpuščeno 35. dan po sprejemu.
Ključne besede: balonska dilatacija; žrebe; ezofagealna striktura; ezofagostoma; pljučnica
ANALISIS PERANCANGAN METODE VLSM DAN FLSM PADA MANAJEMEN IP ADDRESS LAN
Authors: Rahman Nur , Santoso Banu , Pambudi Agung , K Rasyid Rum Mohamad Andri , Mulyatun Sri , Tegris Efrat , Widya Sari Marti
Published: December 2024

Computer networks are very important for people in the current era of modern globalization to access their daily needs. A good computer network is certainly needed to speed up community activities. Sub-netting is one of the things that can be done to optimize IP management on a computer network. This research on the application of the subnetting method on a computer network can be a reference in determining a better subnetting method for building a network. This research aims to analyze the influence of the two subnetting methods on a computer network, compare the network speeds obtained, and the application of the two subnetting methods on a computer network based on QoS parameters. The research results show that the analysis of both subnetting methods displays a very good QoS Index with the following details: FLSM: average throughput 50.792kbps, packet loss 0%, average delay 5.25ms, average jitter 5.37ms. VLSM: average throughput 77.843kbps, packet loss 0%, average delay 3.52ms, average jitter 3.58ms. In the FLSM method, all applied subnets have 101 remaining unused IPs and in VLSM, all applied subnets have 19 unused IPs remaining. This proves that networks designed using the VLSM subnetting method have more optimal network quality and more effective IP management.
REVIEW PEMANFAATAN SAMPAH PLASTIK UNTUK ENERGI DAN BAHAN KONSTRUKSI
Authors: Qomaruddin Mochammad , Tristan Alfian , Faqih Nasyiin , Roehman Fatchur , Mushthofa Mushthofa
Published: December 2024

The problem of plastic waste has become a global concern due to its negative impact on the environment. Plastic, as a non-biodegradable material, results in significant pollution of soil and water. As plastic production increases, efforts to find innovative solutions in reducing environmental impact are important. This article discusses the use of plastic waste as an alternative energy source and construction material. Using a liter-tour review method from various sources that explores the potential of plastics to be converted into energy as well as their use in building materials and as aggregates in concrete. The results of the analysis show that the use of plastic waste can not only reduce pollution, but also provide economic and social benefits, especially as fuel oil and building materials such as paving plastic, plastic aggregate, asphalt plastic mixture.
Discourses of Exclusion: Suppression, Silencing, and Inclusion
Authors:   Nicolaus Copernicus University in Toruń, Więckowska Katarzyna , Kola Anna Maria ,   Nicolaus Copernicus University in Toruń, Bomastyk Michał ,   Nicolaus Copernicus University in Toruń
Published: December 2024

The article provides an introduction to the anthology devoted to studying theories and practices of discourses of exclusion. Framing the discussion by references to Kimberlé Crenshaw’s notion of intersectionality and Michel Foucault’s conceptualization of the relations between discourse and power, the essay stresses the multiple forms of exclusion and entangled power differentials that determine a person’s identity and social status and argues for the need to employ an interdisciplinary perspective. The overview of the issues analyzed in the anthology is guided by the recognition of the complex links between theory and practice and the awareness that exclusions reinforce precarity and dismantle networks of support.
Navigating the Dynamic Convergence of Technology Disruption and Growth
Authors: M Burgess Bonti , Adames-Polanco Aydee , Fournier Gary , R Smith Jason
Published: December 2024

Bonti Burgess, Owner of Bright Day Home Healthcare, had a strategic decision to make. Should Bright Day forge ahead with technological improvements to modernize its operations for long-term revenue growth? Or should the IT infrastructure and CRM system disruptions be put on the back burner under the possibility of a company sale?
Фольклорні записи та фольклоризовані оповідання ОлениПчілки для дітей молодшого шкільного віку: виховний аспект
Authors: Янковська Жанна
Published: December 2024

Olena Pchilka is a famous Ukrainian woman who, at one time, proved herself in various types of scientific, publishing, literary and public activities, permanently inscribed her name in the history of national culture in general. Her selfless work, to which scientists are now returning after years of oblivion in Soviet times, should be properly  appreciated by Ukrainians. This year, there is a great opportunity to honor the writer with such research on her 175th anniversary.
Folklore records and the author's prose of Olena Pchilka, addressed to childrenof preschool and primary school age, deserve special attention, as they contain apowerful educational component, the plot is interesting for children. Therefore, the purpose of this article is to trace the moral and ethical potential embedded in the writer's prose for children of this age group. Considering this, the article uses the principle of textual analysis, as well as the biographical method, since the author recorded (folklore) and wrote her works primarily for her children, while at the same time taking care of all Ukrainians.
As a result of the research, the folklore intentions of Olena Pchilka's prose for children were revealed. She gravitates towards folk art in terms of plot and especially in terms of presentation style.
Therefore, at the level of folkloristic-literary knowledge, we can simultaneously talk about the processes of folklorism and folklorization in her works. This testifies to the writer's deep knowledge and understanding of folklore, including children's folklore, awareness of the extent to which the people's creativity has a powerful educational context.
Taking this into account and relying on the plots of Olena Pchilka's works, we can say that elementary school teachers and parents will find interesting material for reading and discussion in the lessons in the author's works, and in particular those concentrated in the collection «Enough, children, sleep!». This stories will not leave children indifferent and will contribute to the education of the best human traits and moral qualities in them: kindness, responsibility, human dignity, mutual respect, they will receive real lessons of social behavior.
Does TA need a Biological School?
Authors: Hay Julie
Published: December 2024

This article addresses the question of whether we need a new school of Biological Transactional Analysis in reaction to the increasing focus within TA publications on neurodiversity and war. It considers how are we similar to other animals which are not scripted as humans are but show some of the same patterns of behaviour; how some TA concepts and values are inappropriate in some cultures, and challenges the TA approach to war as a psychological process that can be ‘cured’. It concludes that we need take more account of health as well as context.
ÁRVAY SÁNDOR KLINIKUS PROFESSZOR, A DEBRECENI ORVOSTUDOMÁNYI EGYETEM REKTORI HATÁSKÖRŰ DÉKÁNJA (1954−1955), MAJD GYÓGYÍTÓ- MEGELŐZŐ (KLINIKAI) REKTORHELYETTESE (1965−1971)
Authors: Tóth Zoltán
Published: December 2024

Sándor Árvay (1903-1997) was professor and head of the Obstetrics and Gynecology Clinic of the Medical University of Debrecen for 22 years. Three years after his appointment, he performed the duties of a dean of the university with the rights of a rector. Ten years later, as clinical vice rector, he managed the curative and preventive tasks of the university for six years. As a university student, he studied in Debrecen, Budapest, Vienna and Basel. During his clinical internship in Debrecen, he learned the theoretical foundations of experimental medicine at the Institute of Physiology in Basel. After his professional examination, he experienced the practical duties of healing patients as a chief physician in Szikszó, Máramarossziget, and Gyula. Armed with his extensive theoretical and practical experience, he was appointed head of obstetrics. He has developed his clinic into one of the national centers of the profession, and through his extensive national and foreign connections, into an internationally renowned institute. Thanks to his work, 5 department heads, 9 university professors, and 21 head physicians have emerged from his institute, the Árvay school. He was awarded prestigious state and social awards for his outstanding public activities in the leadership of the university and in social organizations. After his retirement, he selflessly helped his colleagues for another 17 years with wise advices and useful observations. His human qualities, modesty, puritanism, broad knowledge and wisdom are exemplary and are respected by all of us. We take great care of his exceptionally rich spiritual legacy, and preserve his memory with respect and grace.
The UNITY OF THE UNIVERSITY STUDENTS AND THE CITY OF PÉCS AGAINST THE TRIANON PEACE TREATY DURING THE INTERWAR PERIOD
Authors: Raposa Vivien
Published: December 2024

In the Horthy era, the maintenance of irredentist goals became crucial among university students. The youth were socialized in a completely different life situation than the adult generation because they had lived through the First World War and the Trianon Peace Treaty as children. In this way, the desire for revision had to be constantly kept alive among youngsters because many of them had grown up without remembering Great Hungary. The aim was also to reinforce the feeling of offense that they did not accept the immutability of the borders. Due to this policy, the government and local city councils wanted the youth to dominate in spreading revisionist ideas.During my present study, I will describe how the city administration of Pécs, and the students collaborated in expressing irredentist purposes. The city council expected the youth not just to take part in various national holidays such as the Heroes’ Memorial Day, the celebration of March 15, or the commemoration of the martyrs of Arad, but also emerge as a key factor in the organisation of ceremonies. In addition, the students regularly participated in the demonstrations, which were organized by the Pécs Group of the Hungarian Revision League and the Pécs-Baranya Circle of the Hungarian National Federation. However, from the beginning of the 1930s, the students started to be more and more active in propagating irredentism, so it also became common for them to hold their revision meetings.
EFFECT OF SURFACE ROUGNESS ON FINITE POROUS JOURNAL BEARING LUBRICATION OF MICROPOLAR FLUID WITH SQUEEZING EFFECT
Authors: Huggi Santosh
Published: December 2024

In this paper, a theoretical analysis of the effect of surface roughness on the squeeze film lubrication of finite porous journal bearings with micropolar fluids is studied. A more generalized form of surface roughness is mathematically modeled by a stochastic random variable with non-zero mean, variance and skewness. The generalized average Reynolds type equation is derived for the squeeze film lubrication of finite rough porous journal bearings with micropolar fluids as lubricant. The closed form expressions are obtained for the fluid film pressure, load carrying capacity, journal centre velocity and locus of the journal centre. The cases of a constant applied load and an alternating applied load are analyzed under a cyclic load the micropolar fluids provide a reduction in the journal centre velocity. Further, it is numerical computations of the results show that the negatively skewed surface roughness pattern increase fluid film pressure, load carrying capacity and decreases the journal centre velocity. Where as adverse effects were found for the positively skewed surface roughness pattern. The effect of porous parameter causes reduction in fliud film pressure, load carrying capacity and enhances the journal centre velocity.
A DATA-DRIVEN METHOD TO DYNAMIC PRICING: UNRAVELLING INVENTORY AND COMPETITOR CONTESTS WITH AI IN E-COMMERCE
Authors: Vashishtha Shikha , Garg Mani , Vimal Megha
Published: December 2024

Dynamic pricing is a critical e-commerce approach that allows firms to modify prices in real time depending on demand, competition activity, and inventory levels. However, successfully adopting such tactics necessitates overcoming obstacles such as accurate demand forecasts, rival pricing monitoring, and inventory turnover optimization. This study presents a data-driven framework that integrates artificial intelligence (AI) techniques, Bayesian optimization, and rule-based systems to provide efficient, flexible pricing strategies. The system use Bayesian Optimization to dynamically balance goals like as revenue maximization, inventory management, and competitiveness, while also including rule-based procedures to assure compliance with business limitations and regulatory norms. Long Short- Term Memory (LSTM) networks are used to estimate demand by modeling temporal trends in sales data, while rival price data is watched and analyzed using web scraping and Natural Language Processing (NLP). Experimental validation of synthetic and real-world e-commerce data shows considerable gains, such as a 22% increase in revenue, a 30% decrease in inventory costs, and improved reaction to competition price. By integrating powerful optimization algorithms with realistic business principles, this framework offers a scalable, efficient, and transparent solution for dynamic pricing in competitive marketplaces. Future research will focus on tailored pricing and explainable AI (XAI) to improve consumer trust and transparency in decision-making.
History Beyond the Textbook
Authors: McLaurin Trent
Published: December 2024

The lived experiences of individuals are different. The historical implications and impact of events will differ depending on who is sharing their experience. As educators, we know the value of listening to stories of others and allowing voice and choice in the classroom. This article will highlight how we can incorporate hip hop culture, specifically emceeing, into the classroom to tell stories that are often overlooked in traditional textbooks and curriculum.
The Effect of Some Antibiotics, Natural and Chemical Compounds on Swarming Motility of Proteus mirabilis
Authors: Al-Zaidi Omar Sinan Sadiq Hussain
Published: December 2024

Background: Proteus mirabilis known for its motility, swimming and swarming motility and involvement in various infections, these two types of motility are important for tissue colonization, thus increase the pathogenicity of the bacteria.
Materials and Methods: Twenty-one isolates from different clinical and animal sources belong to P. mirabilis were collected. The isolates identified using biochemical tests and the Vitek-2 compact system.
Swimmer and swarmer cells media used to detect the effect of antibiotics, sodium azide and tannic acid.
Results: Sodium azide inhibited swimming more effectively than swarming, with higher concentrations (0.1%) showing the greatest inhibition. Tannic acid also inhibited swimming and swarming, with greater effects on swimming cells, particularly from clinical isolates. Swarming motility, especially in animal-derived isolates, exhibited resistance to tannic acid. Additionally, the isolates showed varying resistance levels to antibiotics.
Conclusions: This study demonstrated that, P. mirabilis exhibit different responses to antibiotics, sodium azide and tannic acid according to the type of cells whether it was swimmer or swarmer. Sodium azide and tannic acid inhibit swimming more than swarming cells. Antibiotics resistance patterns was differ according bacterial isolate and type of antibiotic. These finding could be used in future to enhance the activity of antibiotics especially those used to treat gram-negative bacterial infection.
Analysis of The Influence of Inclusive Education Policies and Community Empowerment on Islamic Religious Education at Madrasah Aliyah Al-Aziziyah
Authors: Fattah Ammar Abdul , Ahyar Ahyar , Fahrurrozi Fahrurrozi
Published: December 2024

The aims of this research is to explain the influence of inclusive education policies and community empowerment on Islamic religious education at Madrasah Aliyah Al-Aziziyah. This research uses a quantitative type with an analytical design. This research wants to see whether there is an influence or not on inclusive education policies (X1) and community empowerment (X2) towards Islamic religious education (Y) at Madrasah Aliyah Al-Aziziyah. The population of this study were all teachers and people related to Madrasah Aliyah Al-Aziziyah and the sample was 30 people. The sampling technique used is random sampling. Data collection techniques through observation with questionnaire instruments for inclusive education policies and community empowerment regarding Islamic religious education. The data analysis technique uses the one-way Anova test. The research results show that there is an influence of inclusive education policies and community empowerment on Islamic religious education at Madrasah Aliyah Al-Aziziyah as seen from the significant value obtained in the one-way Anova test which is greater than 0.05 and Islamic religious education has an influence on inclusive education and community empowerment.