bluuebunny/crossref_metadata_2025 huggingface dataset:
Materiały źródłowe do katalogu wydawnictw emigracyjnych, opracowane na podstawie kolekcji Stowarzyszenia Ochrony Poloników Niemieckich w Opolu. Cz. 1 Niemieckie polonika dipisowskie
Authors: Łakomy Maria Kalczyńska, Agnieszka
Published: January 2020

Przedstawiany katalog zawiera 113 opisów pozycji bibliograficznych sporządzonych z autopsji. Jednostka składa się z: nazwiska i imienia autora, tytułu, oznaczenia wydania, miejsca wydania, nazwy wydawcy, daty wydania oraz informacji o cechach fizycznych publikacji. Dane przejęte spoza druki pochodzą ze źródeł bibliograficznych, umieszczone są w nawiasie kwadratowym. Opisy uzupełniono adnotacjami informującymi o liczbie publikacji w zbiorze Stowarzyszenia Ochrony Poloników Niemieckich, znakach proweniencyjnych występujących na poszczególnych egzemplarzach, w wybranych przykładach – o zawartości treściowej. Pozycje zrębu głównego uszeregowane są alfabetycznie według nazwiska pierwszego autora, a przy dziełach anonimowych – według tytułu. Opis jednostek podano zgodnie z pisownią oryginalną. Prezentowana kolekcja druków znajduje się w posiadaniu Stowarzyszenia Ochrony Poloników Niemieckich z Opola.
Kronika
Authors: Krupa Michał
Published: January 2020

I ogólnopolska konferencja naukowa „Ochrona zbiorów bibliotecznych. Przeszłość – teraźniejszość – przyszłość”, Bydgoszcz, Uniwersytet Kazimierza Wielkiego, 19-20 V 2016 r. – Dorota Pietrzkiewicz, Katarzyna Seroka [411-416]

Konferencja naukowa „Książka dawna i jej właściciele – stan badań, opracowanie, perspektywy”, Wrocław, Zakład Narodowy im. Ossolińskich, – 29 IX – 1 X 2016 r. – Martyna Osuch [417-421]

Znawcy opraw w Coburgu. 21. Kongres zorganizowany przez Arbeitskreis für die Erfassung, Erschliessung und Erhaltung historischer Bucheinbände (AEB), Biblioteka Krajowa w Coburgu (Landesbibliothek Coburg), 27-29 X 2016 r. – Joanna Milewska-Kozłowska [422-426]

Konferencja naukowa „Księgozbiory historyczne w bibliotekach archiwów państwowych”, Archiwum Państwowe w Szczecinie, 29 XI 2016 – Janina Kosman [427-434]
„Nie poszliśmy więc do polityki. Ale oto polityka przyszła do nas” ‒ rola bibliotekarza w okresie stalinowskim (w świetle materiałów zamieszczanych na łamach polskich czasopism zawodowych)
Authors: Łuszpak Agnieszka
Published: January 2020

Polish librarianship in the stalinist period (1948-1956) had to face new challenges. In the changed political and social reality, both the role of a librarian and the functions performed by public and scientific libraries had to be redefined. The profile of vocational education also changed. From the various materials (papers, guidelines of the party and departmental authorities, reports, protocols of the Polish Librarians and Archivists Union) published in professional journals of the time – „Przegląd Biblioteczny”, „Bibliotekarz” and „Poradnik Bibliotekarza” – it appears that librarians had to focus on the ideological aspect of their work, educating the reader in the socialist spirit.
Szyszkowiana/pseudoszyszkowiana z dawnego księgozbioru bernardynów z Karczówki, przechowywane obecnie w zbiorach Biblioteki Wyższego Seminarium Duchownego w Kielcach. Komunikat („Vilescit quilibet semper apignis liber infirmatur”, wpis w jednej z książek
Authors: Kardyś Piotr
Published: January 2020

The article discusses the significance of the six old prints of the old library of the Bernadines of Karczówka (now within the boundaries of the contemporary Kielce city) that include the provenance notes denoting them to be the gift of Kraków bishop Marcin Szyszkowski from the year 1630. However, it is well known that, according to the recent research, bishop Szyszkowski was against assuming the church of St. Charles Borromeo by the said Bernardines. It is thus justified to consider the six old prints to be some kind of the corner stone of the foundation giving the Bernardines the rights to Karczówka. The other two old prints form the nephew of bishop Szyszkowski seem to support the hypothesis. These findings were been made possible thanks to the detailed survey conducted in the Library of the Seminary in Kielce while working on the monograph of the library of the Bernardines of Karczówka.
Recenzje
Authors: Puchalski Jacek , Sanojca Karol , Kamińska-Chełminiak Kamila
Published: January 2020

Halina Rusińska-Giertych, Kultura książki polskiej we Lwowie w okresie oświecenia, Wrocław: Wydawnictwo Uniwersytetu Wrocławskiego, 2018, Acta Universitatis Wratislaviensis, No 3815, ss. 388, [1] s., [1] k. tab. złożona, il., ISBN 978-83-229-3593-4.

Maria Konopka, Polski rynek wydawniczy Lwowa w dobie autonomii galicyjskiej (1867-1914), Kraków: Towarzystwo Autorów i Wydawców Prac Naukowych „Universitas”, 2018, ss. 437, [2] s., [1] k. tab. złożona, il., ISBN: 97883-242-3136-2, 9788324232963.

Jacek PuchalskiKatedra Książki i Historii MediówWydział Dziennikarstwa, Informacji i Bibliologii Uniwersytet Warszawski, Warszawa, Polskajacek.puchalski@interia.plORCID 0000-0003-2023-6988

Z Badań nad Książką i Księgozbiorami Historycznymi 2018, t. 12, s. 449-454.

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Agnieszka Gołda, Teoria bibliografii w II Rzeczypospolitej, Katowice: Wydawnictwo Uniwersytetu Śląskiego 2018, ss. 401, Prace Naukowe Uniwersytetu Śląskiego w Katowicach nr 3722; ISSN 0208-6336, ISBN 978-83-226-3337-3 (wersja drukowana), ISBN 978-83-226-3338-0 (wersja elektroniczna).

Karol SanojcaInstytut HistorycznyWydział Nauk Historycznych i Pedagogicznych, Uniwersytet Wrocławski, Wrocław, Polskakarol.sanojca@uwr.edu.plORCID 0000-0001-8630-0589

Z Badań nad Książką i Księgozbiorami Historycznymi 2018, t. 12, s. 454-457.

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Przewodnik po zasobie Archiwum Instytutu Literackiego Kultura, oprac. Maria Wrede, Warszawa: Biblioteka Narodowa, 2018, ss. 147, il., ISBN 978-83-7009-693-9.

Kamila Kamińska-ChełminiakKatedra Książki i Historii MediówWydział Dziennikarstwa, Informacji i Bibliologii, Uniwersytet Warszawski, Warszawa, Polskaka.kaminska@uw.edu.plORCID 0000-0002-6082-0444

Z Badań nad Książką i Księgozbiorami Historycznymi 2018, t. 12, s. 458-463.
Slovak humanist Ondrej Rochotský (ca. 1583-1623) and his works stored in the Wrocław University Library
Authors: Škovierová Angela
Published: January 2020

Humanist poet Ondrej Rochotský (Andreas Rochotius) belongs to the relatively large group of Slovak humanist writers who lived and worked outside Slovakia and their relationship to Slovakia is only reflected in their work. His literary work (two theatre plays, professional literature, reflexive poetry and amount of congratulations, condolences and other occasional verses) as well as relationships with others, especially Czech humanistic writers, are very rich. His relationship with the Czech nobleman Karel the Elder from Žerotín (Karel starší so Žerotína) is particularly significant. This is probably the time of Karel’s stay in Wrocław in the years 1628-1633, when the Wrocław’s University Library (WUL; Biblioteka Uniwersytecka we Wrocławiu) received and have been storing convolute with a few printed works of O. Rochotský, with his handwritten dedication inside. The aim of the paper is to clarify literary activities of O. Rochotský, to analyse his personality at the background of the social, cultural and political context of the first three decades of the 17th century and to discuss in brief Rochotský works found in the WUL.
Autorskie autografy na egzemplarzach starych druków XVI-XVIII w., zachowanych we Lwowskiej Narodowej Naukowej Bibliotece Ukrainy im. Wasyla Stefanyka
Authors: Kachur Iryna
Published: January 2020

The author’s autographs in the early printed books from the collection of the Vasyl Stefanyk Lviv National Scientific Library of Ukraine can be grouped in two categories. The first one includes author’s signatures, their individual notes concerning the book, amendments and supplements to the text. These materials, quite rare in the books, are of particular importance for the researchers of the history of writing and printing. They can become an authoritative reference for dating, settling authorship of anonymous works, preparations of critical editions. The following authors are mentioned in the text: Mikołaj Bernett (1643-1710), Stanisław Brzeżański (ca 1650-1738), Tadeusz Juda Krusiński (1675-1757), Gottfried Lengnich (16891774), Ignacy Krasicki (1735-1801). The other category of author’s autographs, bigger and as precious as the previous one, includes hand-written author’s dedications. The annex to this text registers 67 Polish dedications from the 16-18th centuries. The following famous persons can be found among authors and recipients: Erazm of Rotterdam, Ercole Sassonia, Martinus Glicius of Pilzno, Andrzej Wolan, and Daniel Mikołajewski.
Księgozbiór Magdaleny Morskiej (1762-1847) w Bibliotece Ossolineum
Authors: Sidorowicz-Mulak Dorota
Published: January 2020

Magdalena Morska, the owner of the Zarzecze residence, where she created a sentimental-romantic park and garden was a Polish aristocrat and keen organizer of cultural life in Galicia province of Poland. She donated a collection of 358 titles of books and periodicals in 1228 volumes to the Ossolineum Library in 1847. They were mostly books in French published between 1785-1835. In the article an overview of this collection is given. The collection consists mostly of belles-lettres, historical and political works. Also books on geography, especially itinerary accounts are vastly represented, as well as philosophy, including leading authors of European Enlightenment, books on art, poetry, drama, works on botanic and gardening. In Morska’s library there were also volumes of typically women’s literature of the period: romances, moralizing literature, educational books, language dictionaries and grammar manuals. In spite of a substantial book collection of count Morska, there was no separate library room in the Zarzecze palace.
A religiosidade para pessoas vivendo com HIV/Aids: um estudo de representações sociais
Authors: Gomes Antonio Marcos Tosoli , Marques Sergio Corrêa , Nogueira Virginia Paiva Figueiredo , Collares-da-Rocha Julio Cesar Cruz , Pereira Gerson Lourenço , Apostolidis Themistoklis , França Luiz Carlos Moraes , Souza Karen Paula Damasceno dos Santos , Das Merces Magno Conceição , Couto Pablo Luiz Santos , Paes Leandra da Silva , Wolter Rafael Moura Coelho Pecly
Published: January 2020

Introdução: A religiosidade consiste no apoio de enfrentamentos cotidianos relativos í  existência humana e subjetivados pela convivência com uma condição crônica e estigmatizada. Objetivo: Analisar as representações sociais da religiosidade para pessoas vivendo com HIV/Aids (PVHA). Métodos: Estudo descritivo, qualitativo, í  luz da teoria do núcleo central das representações sociais. Participaram 165 PVHA atendidas no ambulatório especializado de um hospital universitário do municí­pio do Rio de Janeiro. Utilizou-se um questionário sociodemográfico e a técnica de evocação livre ao termo indutor religiosidade. Os dados foram tratados respectivamente no software Excel e EVOC, o qual possibilitou a construção do quadro de quatro casas. Resultados: A maioria dos participantes (61,8%) é do sexo masculino, com ensino fundamental completo (47,9%), 38,2% são católicas, 24,9% espí­ritas/espiritualistas, 20% protestantes e 17,6% sem religião. Concernente ao núcleo central figuram as palavras fé, Deus e acreditar; e no sistema periférico elementos relacionados í  prática da religiosidade. As PVHA representam-na como o exercí­cio da fé através do transcendente, de uma instituição religiosa, da crença e do reflexo desta dimensão para ressignificar sua condição. Conclusão: A religiosidade ocupa um espaço de crença/prática para elas.Palavras-chave: psicologia social, religião, HIV.
The ratio of erythrocyte populations in the blood of puppies during postnatal oxidative stress
Authors: Anﬁorova M. , Broshkov M. , Danchuk O.
Published: January 2020

The article presents new scientiﬁ c data on the ratio of erythrocyte populations in puppies' blood during postnatal oxidative stress. It was established that the number of erythrocytes in the blood of one-day-old puppies was 5.64 ± 0.12 T / l, and half of these cells belonged to the population of "mature", 40% - "young" and 10% - "old". In day-old puppies, the content of lipid peroxidation products in erythrocyte hemolysates is quite high, which indicates the development of postnatal oxidative stress. Thus, the content of diene conjugates, ketodienes and Schiﬀ bases is respectively 1,406 ± 0,023 Conv. units, 0.676 ± 0.004 Conv. units and 0.135 ± 0.003 Conv. units. From one to ﬁ ve days age of puppies the number of erythrocytes in the blooddecrease by 1.5 times (p<0.001), mainly due to the decrease in the number of "mature" cells (by 1.6 times; p<0.001). The intensity of peroxide oxidation in the body of puppies even a month after birth is relatively high, as indicated by the content of Schiﬀ bases in the erythrocytes of the blood of these animals - 0.185 ± 0.002 Conv.units. The inverse correlations of the content of Schiﬀ bases in erythrocyte hemolysate with their number in the bloodstream were found to be r = -0.83 (p<0.001). It should also be noted the direct correlation of the content of diene conjugates in the blood of puppies with the number of erythrocytes in their blood (r = 0,58 p <0,05), but the content of ketodienes and conjugated trienes is inversely related to the content of "young" erythroid cells in the puppies' blood (r = -0.57 p <0.05). Consequently, post-natal adaptation of puppies results in the replacement of fetal erythrocytes by postnatal cells, and this process is associated with the intensiﬁ cation of peroxide oxidation and accumulation of the end products of peroxidationin the cells. This process isaccompanied by an acceleration of the process of "aging" of young forms of erythrocytes, as a result of which prerequisites for the development of anemiaare created.
Key words: erythrocytes, oxidative stress, puppies, Schiﬀ bases, ketodienes, diene conjugates.
Hemocytopoiesis and microelements metabolism’s indices in calves under the inﬂ uence of national vitamin-amino-acid complex
Authors: Melnyk A. , Bezukh V. , Dubin O. , Moskalenko V. , Vovkotrub N. , Bogatko L. , Tyshkivsky M.
Published: January 2020

In Ukrainian veterinary medicine the study of the eﬀ ectiveness of new complex drugs remains relevant. The eﬀ ect of the vitamin-mineral complex "Alphabet for Animals" on the state of hemocytopoiesis and the microelements metabolism in calves of 1.5‒2.5 months of age were studied. The composition of this drug includes the biologically active substances: vitamins A, D3, E, B1, B3, B5, B6, B12, K3 and essential amino-acids: DL-methionine, L-lysine and arginine. It is used in farm animals and poultry for the normalization of hemocytopoiesis, the prevention and treatment of vitamins and trace elements metabolism’s disorders. In the ﬁ rst week of drug administration, the number of erythrocytes in the experimental animals group has increased signiﬁ cantly (p<0.05) and after its second feeding, the positive eﬀ ect on erythrocytopoiesis in calves has became even greater (p<0.001), compared to the calves in control group. The level of hemoglobin in calves of experimental group also increased signiﬁ cantly from the beginning of the drug to the end of the experiment, whereas in calves of the control group there was a tendency to decrease its level throughout the all experiment. The color index and erythrocyte saturation by hemoglobin (MCH) at the ﬁ rst and second blood samples were signiﬁ cantly decreased (p<0.05) in control calves group, whereas in animals of experimental group there was no signiﬁ cant diﬀ erence between these parameters (p<0.1). The average volume of red blood cells did not diﬀ er between control and test calves during the experiment (p<0.1). Under the drugs inﬂ uence the Ferum blood content in calves of experimental group increased by 24.2 %. In the control calves group, this tendency was not so noticeable (the increase of Ferum serum level at the end of experiment was only +7.8 % (p<0.1), compared to the initial indices). The Zinc metabolism, on the contrary, has not undergone signiﬁ cant changes. The Cuprum serum level in experimental calves group remained always signiﬁ cantly higher than in control animals group. “Alphabet for Animals” has a positive eﬀ ect on hemocytopoiesis in calves due to its complex composition (fat-soluble and water-soluble vitamins, aminoacids) and improves the metabolism of microelements, including Ferum and Cuprum. The inﬂ uence on these processes the vitamins of B group, which are a part of this drug, we consider especially valuable in the conditions of the unformed rumen digestion in young cattle.
Key words: vitamin-amino acid complex, erythrocytopoiesis, hypochromia, microcytosis, hemoglobin, color index, hematocrit.
EVALUASI PROGRAM PEMBINAAN PRESTASI OLAHRAGA BOLA VOLI PADA SMK NEGERI DI KOTA BENGKULU
Authors: Candrawati Yunita , Sugiyanto Sugiyanto , Ilahi Bogy Restu
Published: January 2020

AbstrakPenelitian ini bertujuan untuk mendeskripsikan Evaluasi Program Pembinan Prestasi Olahraga Bola Voli pada SMK Negeri Di Kota Bengkulu. Subjek dalam penelitian ini adalah Pembina, Pelatih, Atlet SMK Negeri 1, SMK Negeri 3, SMK Negeri 5, SMK Negeri 7 Kota Bengkulu. Pengumpulan data dan Instrumen penelitian ini berupa kuesioner/angket yang sudah divalidasi oleh ahli. Analisis data dalam penelitian ini menggunakan analisis data kualitatif dan keabsahan data statistik yang menggunakan rumus persentase. Hasil penelitian dalam pembahasan menunjukan bahwa hasil Evaluasi Program Pembinaan Prestasi Olahraga Bola Voli Pada SMK Negeri Di Kota Bengkulu belum seluruhnya maksimal dalam pelaksanaannya dari 4 sekolah yang diteliti hanya 1 sekolah yang menjalankan program pembinaan dengan baik. Hal tersebut dilihat dari segi manajemen pengelolaan sarana dan prasaranan yang sangat minim, pengelolaan dana yang belum tersalurkan menyeluruh untuk kegiatan program pembinaan tersebut, serta kurangnya dukungan dari pihak sekolah. Kurang maksimalnya program latihan yang diberikan pelatih, membuat tujuan pencapaian prestasi puncak tidak dapat terlaksana dengan baik. Kesimpulan dari program pembinaan belum maksimal dari segi prasarana, pengelolaan dana, serta dukungan dari sekolah dari 4 sekolah yang di teliti hanya 25 % sekolah yang sudah melaksanakan program dengan baik.Kata Kunci: Evaluasi, Program Pembinaan Prestasi, Bola VoliAbstractThis study aimed to describe the Evaluation of the Achiefment Volley Ball Training Program at Vocational School in Bengkulu City. The subject of  this study is trainerss, coachers, atlhetes of  SMKN 1, SMKN 3, SMKN 5, SMKN 7 Bengkulu city. Dt colection and instrumen of the study is kuestionnaire which has been validated by expert. Data analisis oif this study used kualitative data analysis and statistic data validity used percentage the result of this study showed that the of grall result of the evaluation of the achievement volly ball training program at vocational school in Bengkulu city are not maximal yet in the implementation. from 4 school are studied, there is only one school which implement development program well. It can be seen from the lact of the good mnagement of facilities and infrastructure, the management of the found whish is not distributed yet for the development program, and the lact of support from school. Since the lack of training program from coachers, it makes the aim program of the peak achievement cannot be implemented well. The conclution of this study is dhat the development program is not running well in mangement of facility and infrastructures, management from school. From 4 schools are studied, there is only 25% which has implemented the development program well.Keywords: Evaluation, Achiefment Training Program, Volley Ball
ANALISIS KEMAMPUAN OPEN SPIKE PADA SISWA PUTRA EKSTRAKURIKULER BOLA VOLI DI SMPN 18 KOTA BENGKULU
Authors: Herianto Heru , Yarmani Yarmani , Sutisyana Ari , Defliyanto Defliyanto
Published: January 2020

Abstractresearch aims to know analysis ability open spike in son studen ey ball in SMPN 18 bengkulu city. The research is descriptive qua arch the population is all student extracurricular volley ball SM numbered threety people son student. On this research sampl ch follow extracurricular volley ball in SMPN 18 Bengkulu cityarch created on individual not a team. Analysis of data u ntitative with a percentage. The result of research showed that an son student extracurricular volle ball in SMPN 18 Bengkulu c egory 0, good category 2 people student or 6,6%, enough cat ent or 13,33%, medium category 4 people student or 13,33%, l ple student or 33,33% and very less category 10 people student o alue rating is 16,03 result of research Analysis ability open spike acurricular volley ball in SMPN 18 Bengkulu city at in the less categorykeywords: Open spike, volley ball and extracuriculer
Implementasi Metode Rondo Untuk Meningkatkan Teknik Passing Mahasiswa Pada Mata Kuliah Futsal Penjas Prodi Penjas FKIP UNIB
Authors: Sugiyanto Sugiyanto , Ilahi Bogy Restu , Defliyanto Defliyanto
Published: January 2020

Abstract            This study aims to find out how the Implementation of the Rondo Method to Improve Student Passing Techniques in Futsal Courses so as to improve the learning quality of seventh semester students in Class A Penjas Study Program FKIP Unib. Through the rondo method students are included in groups to practice passing. The hope is that students have an active and contributive attitude so that getting meaningful learning both individually and in groups and improving the quality of learning in Futsal courses is achieved. The subjects of this study were seventh semester students of class A Penjas Study Program FKIP UNIB who were taking the Futsal Orpil course. Data collection techniques were carried out by means of tests conducted at the beginning and at the end of the cycle, there was an increase in the skills of basic passing techniques before and after using the rondo method in the first cycle, which proved to be an increase of 50% of 20 students who received complete grades from 40 students based on details percentage value (A) 12 people, (B) 8 people, (C) 20 people using the rondo method with 1 person being a guard. In cycle II there was an increase in passing skills in the rondo futsal game method with 2 students who became guards. Evident from the results of the study with the results of a 65% increase in completeness from the first cycle which only 50% completed from 40 students with details of the value (A) 16 people, (B) 9 people, (C) 15 people. There was an increase from the first cycle, namely 15% increase with completeness from 20 students to 26 students who completed Futsal learningKeywords: Rondo, Passing, Futsal
Estuarine-terrestrial habitat gradients enhance nursery function for resident and transient fishes in the San Francisco Estuary
Authors: Colombano DD , Manfree AD , O’Rear TA , Durand JR , Moyle PB
Published: January 2020

Nursery functions of US West Coast drowned river valley estuaries are not well understood. Using long-term fish-monitoring data (1995-2017) in Suisun Marsh, San Francisco Estuary, California, USA, we examined spatial and temporal trends in abundance and apparent growth of fishes with diverse life-history types. Focal species were Sacramento splittailPogonichthys macrolepidotus, striped bassMorone saxatilis, tule perchHysterocarpus traski, and starry flounderPlatichthys stellatus, which collectively represented 55% of total catch (n = 140092). We identified keystone habitat patches that functioned as nursery hotspots during the peak young-of-the-year recruitment window. Deep, flow-through sloughs close to the open estuary were important nursery habitats for the marine transient starry flounder. In contrast, splittail and striped bass mostly migrated through such corridors to rear in shallow, dead-end sloughs bisecting tidal marsh plains, managed tidal ponds, and uplands. Tule perch were concentrated in shallow, interior sloughs, reflecting their resident life-history type and adaptations to variable conditions in a small home range. Interactions among freshwater flows and stationary habitat features (e.g. channel depth, land-to-open-water ratio) were related to fish abundance; however, species and age classes differed in their relationships to these interactions, suggesting a mechanism for habitat partitioning in space and time. Overall, we inferred that habitat connectivity—longitudinal, lateral, and vertical—along the estuarine-terrestrial gradient was a driver of fish species diversity and productivity. Consideration of seascape-landscape dynamics across multiple spatial and temporal scales in estuaries should help maintain or increase fish populations and ecological resilience in the face of rising sea levels and other environmental stressors.
Frequency of inflammatory bowel diseases in patients with ankylosing spondylitis
Authors: Lukina G. V. , Kulakova P. I. , Novikov A. A. , Savenkova N. A. , Alexandrova E. A. , Volnukhin E. V. , Kovshik A. N.
Published: January 2020

Background. Аnkylosing spondylitis (AS) is closely associated with inflammatory bowel disease (IBD). 5–10 % of patients with SpA eventually develop inflammatory bowel disease, with Crohn's disease being more common than ulcerative colitis. Colonoscopy is usually used to diagnose inflammatory bowel disease, but this procedure is invasive. FC is clinically used to detect IBD and correlates well with clinical, endoscopic, and histological indicators of disease activity in IBD.

The aim. To evaluate the incidence of inflammatory bowel disease in patients with ankylosing spondylitis.

Materials and methods. In the analysis were included 40 patients with ankylosing spondylitis, among them 26 (65.0 %) men, and 14 (35.0 %) women, the average age of patients was 41.2 ± 10.5, the duration of the disease was on average 13.0 ± 8.8 years. All patients were examined with ESR, CRP, esophagogastroduodenoscopy, colonoscopy and quantitative analysis of the fecal calprotectin levels using the method of lateral immunochromatography with the BUHLMANN Quantum Blue rapid test. Standart range: 100–1,800 µg/g.

Results. All patients had a high disease activity, the average BASDAI was 5.2 ± 1.7, the average ASDAS CRP 3.8 ± 1.1. 35 (87.5 %) patients had calprotectin level more than 100 µg/g, the remaining 5 (12.5 %) patients less than 100 µg/g. 12 (30.0 %) patients had the calprotectin level more than 1,800 µg/g, 23 (57.5 %) from 101 to 1800 µg/g. All patients with FC levels more than 100 µg/g showed an increase CRP level (mean 28.4 mg/l) and ESR (mean 36.3 mm/h). IBD were diagnosed in 9 (22.5 %) cases: 5 (12.5 %) patients with Crohn's disease and 4 (10 %) patients with ulcerative colitis, in the remaining (77.5 %) cases there was no intestinal pathology.

Conclusion. The results showed high frequency of IBD in patients with AS. Patients with high fecal calprotectin levels (more than 100 μg/g) had high disease activity (AS). In most cases, inflammatory bowel disease were diagnosed in patients AS with fecal calprotectin levels more than 100 µg/g.
To help practitioner: monitoring treatment of osteoporosis in study of bone mineral density on different axial densitometers
Authors: Nikitinskaya O. A. , Toroptsova N. V.
Published: January 2020

Dual-energy X-ray absorptiometry is recognized as the ‘gold standard’ for the diagnosis of osteoporosis. This method is used not only for the initial assessment of the state of the IPC, but also for further monitoring of treatment or preventive measures. It allows you to compare the data of a patient with successive measurements during a long observation. However, it is impossible to evaluate the results of studies in dynamics on devices of different manufacturers without standardizing indicators or introducing correction factors. A simple method for recalculating the T-score obtained on a Dexxum 3 apparatus (OsteoSys, South Korea) is presented in order to compare it with a similar indicator of a bone densitometer Lunar Prodigy (GE Healthcare, USA).
Assessment of outpatient primary care physicians’ awareness of Takayasu arteritis
Authors: Borodina I. E. , Popov A. A. , Shardina L. A. , Kozulin A. A. , Osadchaya N. A.
Published: January 2020

Takayasu arteritis (TA) is a rare disease. Due to the variety of clinical manifestations the patients may primarily apply to general practitioner or other specialist.

Aim. To assess the awareness of primary care physicians and outpatient department specialists of TA clinical manifestation, diagnosis criteria and treatment issues.

Methods. 200 physicians consented to take part in a survey. The study sample included 50 internists, 25 neurologists, 21 gastroenterologists, 18 rheumatologists, 28 cardiologists, 45 pediatricians, 13 nephrologists practicing at the outpatient departments of the city of Yekaterinburg and Sverdlovsk region.

Results. Among the related specialists, the most freuent incorrect answers were given on intermittent claudication (48 % correct), involved arteries (49 %). Rare application of TA diagnostic criteria (32 %), low awareness of the TA diagnostic standard (39 %) was found. The survey results confirm previously reported data on the low awareness of TA by primary care physicians.

Conclusion. This is the first study to assess the primary medical service specialists awareness in the Russian Federation. Diagnosis and treatment of TA should be included in a number of educational programs and resources for continuing vocational education.
Bone mineral density in women of reproductive age with rheumatic diseases
Authors: Dobrovolskaya O. V. , Dyomin N. V. , Smirnov A. V. , Shornikova I. A. , Toroptsova N. V.
Published: January 2020

The article is devoted to the study of bone mineral density (BMD) in women of reproductive age suffering from rheumatic diseases (RD). A survey was conducted of 134 women — 94 patients with RD (rheumatoid arthritis, systemic scleroderma and psoriatic arthritis) and 40 people without RD. Reduced BMD was detected significantly more often in the group of patients with RE compared with the healthy control (25 and 8 %, respectively; p = 0.0213). Patients with RD showed a direct association of BMD values in all measurement areas with height, weight, body mass index, serum vitamin D concentration, and the reverse — with a cumulative dose of glucocorticoids; For MPC of the proximal femur, an additional relationship was revealed with the duration of RD. Thus, a quarter of women with RD in reproductive age need to be monitored, and in the presence of fractures, treatment of osteoporosis.
Clinical case of malaria determining using modern laboratory diagnostics methods
Authors: Ozeryanskaya A. Yu. , Kazakov S. P.
Published: January 2020

The article describes a clinical case of malaria in patient X., who was admitted to the medical institution of the Ministry of Defense. The patient was diagnosed with acute leukemia based on complaints and the clinical picture, followed by transferring the patient to the hematology centre of the Main Military Clinical Hospital n. a. N. N. Burdenko. In a short time, the patient was diagnosed with laboratory tests of the Department of Clinical and Hematological Research, and the diagnosis was reported to the specialists of the hematological centre. The patient was promptly provided with the necessary medical care. Due to the rare occurrence of this parasitic disease (the last case of malaria we diagnosed 10 years ago), we conducted a comprehensive study using various laboratory methods and modern hematological analyzers. All this made possible to recognize this disease, which is rare in the Moscow region, as well as in other regions of the Russian Federation, in a short period of time.
Dry disposal technology in transportation and processing of reusable medical devices
Authors: Demidov P. A.
Published: January 2020

The processing of multiple-use medical devices (MD) between patient use is an integral part of anti-epidemic measures in a medical organization (MO) and directly affects the safety of medical services. Based on the requirements of the Sanitary Rules and Regulations 2.1.3.2630–10 it is possible to use washing and disinfecting machines for disinfection purposes. At the same time, there remains the problem of organizing the operation of the operating unit and the central medical department of the medical organization for transportation and work with MD contaminated with blood and other biological fluids.
Endothelial dysfunction in context of women’s health disorders from menarche to menopause
Authors: Kuznetsova I. V.
Published: January 2020

Endothelial function is an essential component of providing homeostasis, which allows controlling the state of the vascular bed and ensuring blood supply to organs both under physiological conditions and under the influence of various damaging factors. Endothelial dysfunction is associated with a wide range of pathological conditions and diseases, in the pathogenesis of which the vascular link is involved. Understanding the unifying role of endothelial dysfunction in the pathology of different fields of medicine allows, firstly, to predict the development of serious socially significant diseases, such as cardiovascular diseases, which remain the main cause of death among women. In particular, over the past decade, several cardiovascular risk factors specific to the female population have been identified, such as hypertensive pregnancy complications and menopausal vasomotor symptoms, which, in turn, are caused by endothelial dysfunction. Secondly, timely treatment of endotheliosis suspends or completely prevents both transient disorders associated with endothelial dysfunction and their serious consequences. In this regard, the drug group of glycosaminoglycans and its representative sulodexide are of interest.
Immunomodulatory therapy in integrated treatment of exacerbation of chronic nonspecific sialadenitis in patients of elder age groups
Authors: Serbin A. S. , Maksyutin I. A. , Afanasyeva О. Yu. , Aleshanov K. A. , Kuchkina I. V. , Zotyeva Yu. A.
Published: January 2020

The article is devoted to the problem of efficiency improvement of the integrated treatment of exacerbation of chronic nonspecific sialadenitis in the patients of elder age groups. The results of clinical and immunological examination and treatment of 47 elderly and senile patients with exacerbation of chronic nonspecific sialadenitis are presented. Depression of the immune status components is revealed. It is shown that inclusion of polyoxidonium in the integrated treatment schedule of this pathology allows optimizing parameters of the local and systemic immunity, improving efficiency of the treatment, reducing patients' period of stay at in-patient hospital.
Enzymes from carbohydrase group destroy biofilm matrix of gram-positive and gram-negative bacteria
Authors: Romanova Yu. M. , Tutelyan A. V. , Sinitsyn A. P. , Pisarev V. M. , Alekseeva N. V. , Filipova N. I. , Tolordava E. R. , Sinitsyna O. A. , Emshanov O. V.
Published: January 2020

The effect of enzymes carbohydrases exopolysaccharide matrix of biofilms formed by gram-positive and gram-negative bacteria on abiotic surfaces was studied. The ability of a mixture of carbohydrase enzymes (hydrolases and lyases) to completely destroy the matrix of biofilms formed by gram-positive and gram-negative bacteria causing health-associated infections has been confirmed. An optimal mixture of carbohydrases possesed high anti-biofilm activity even when employed in relatively small concentrations and at a brief exposure time.
Hyperammonemia in clinical practice: analysis of own clinical observations
Authors: Galeeva Z. M. , Galiullin O. F. , Yeziukova E. G. , Tukhbatullina R. G.
Published: January 2020

The article presents scientific data on the role of ammonia in the human body, examines in detail the mechanism of formation and utilization of ammonia in the body. The questions of etiology and separate forms of pathogenesis of hyperammonemia, and its influence on the processes of fibrosis in the liver and the role of stellate liver cells in it are highlighted separately. The data on the influence of hyperammonemia on cognitive functions of the brain with the development of encephalopathy are presented, which is of great importance in clinical practice, during medical examination. The data of own observations are given, the questions of drug therapy are highlighted.
Disbiotic changes in patients with non-alcoholic fatty liver disease
Authors: Sirchak E. S. , Griga V. I. , Pichkar Yo. I. , Kurchak N. Yu.
Published: January 2020

The results of study at 96 patients with non-alcoholic fatty liver disease are presented. A high incidence of intestinal microbiome disorders was observed in the examined patients, especially at the stage of non-alcoholic steatohepatitis. The relationship between the persistence of impaired lipid metabolism and the degree of dysbiosis of the colon, namely between grade II dysbiosis and the level of total cholesterol in patients with non-alcoholic fatty hepatosis (r = 0.77; p < 0.01), and grade III dysbiosis and total cholesterol, triglycerides in patients with non-alcoholic fatty steatohepatitis.
Colon dysbiosis, increasing of intestinal wall permeability and non-alcohol fatty liver disease
Authors: Uspensky Yu. P. , Baryshnikova N. V. , Balukova E. V.
Published: January 2020

In the light of modern ideas about the pathogenesis of non-alcoholic fatty liver disease (NAFLD), along with the decoding of the genetic polymorphism of genes that regulate lipid and carbohydrate metabolism, immune factors, metabolic disorders and inflammation, a key role in the pathogenesis of the disease belongs to the intestinal microbiota, which takes part in development of all stages of NAFLD. The article presents the pathogenetic relationships of intestinal microbiota and metabolic disorders.
Non-alcoholic fatty liver disease and psoriasis: random combination or regular relationship?
Authors: Akhmedov V. A. , Melikov T. I.
Published: January 2020

Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways. Recent observational studies have shown that the prevalence of NAFLD is remarkably higher in psoriatic patients (occurring in up to 50 % of these patients) than in matched control subjects. Notably, psoriasis is associated with NAFLD even after adjusting for metabolic syndrome traits and other potential confounding factors. Some studies have also suggested that psoriatic patients are more likely to have the more advanced forms of NAFLD than non-psoriatic controls. The use of drug therapy in patients with a combination of NAFLD and psoriasis with the inclusion of the drug Legalon is pathogenetically justified.
The effectiveness of rehabilitation of children 5-8 years old with spastic forms of cerebral palsy, according to clinical assessment and thermal imaging
Authors: Volovik M. G. , Sheiko G. E. , Kuznetsov A. N.
Published: January 2020

In order to assess the effectiveness of rehabilitation measures, a comprehensive examination was conducted using standardized scales and thermal imaging in two groups of patients aged 5–8 years old with spastic forms of cerebral palsy. The sample consisted of 10 children with a diagnosis of G80.1 and 10 with a diagnosis of G80.2, the degree of impaired motor function levels 1 and 2 according to GMFCS. Rehabilitation interventions were carried out for one year in stationary (two times a year, courses of 14 days), outpatient (2–3 courses of massage for 10 days, botulinum therapy) and home (daily exercise) conditions. The complex included physical therapy, kinesiotherapy, mechanotherapy, physiotherapy and reflextherapy, massage, classes with a speech therapist and defectologist, if necessary — pharmacotherapy. A discrepancy in a number of cases of thermal imaging and clinical results of treatment is received, the attempt of theoretical explanation of these discrepancies is made. The possibilities of thermal imaging evaluation of treatment effectiveness in children with spastic forms of cerebral palsy, which allows to count on success in the development of working methods of convenient, non-invasive and high-precision method of objectification of motor disorders at the stages of rehabilitation, are demonstrated. Further improvement of the proposed approach is promising in terms of creating a reliable means of validating standardized clinical scales and questionnaires.
MENINGKATKAN LITERASI SAINS SISWA KELAS 7 MELALUI PEMBELAJARAN INKUIRI MENGGUNAKAN BAHAN AJAR BERBASIS PROYEK PADA MATERI ENERGI
Authors: Hardjo Fanni Nadia , Permanasari Anna , Permana Irvan
Published: January 2020

Penelitian ini bertujuan untuk mengetahui profil pembelajaran inkuiri menggunakan bahan ajar berbasis proyek yang dapat meningkatkan literasi sains siswa pada materi energi. Metode penelitian yang digunakan dalam penelitian ini adalah metode analisis deskriptif. Instrumen yang digunakan dalam penelitian ini terdiri dari lembar angket untuk mengetahui respon siswa dan guru terhadap pembelajaran dan untuk mengetahui peningkatan literasi sains siswa dilakukan tes pilihan ganda berbasis literasi sains. Hasil penelitian menunjukkan bahwa pembelajaran inkuiri dapat meningkatkan literasi sains siswa dengan menggunakan bahan ajar berbasis proyek ditunjukan dengan kenaikan hasil belajar dengan rata-rata pretest sebesar 54, rata-rata posttest sebesar 69 dan Ngain 0,43 (sedang). Bahan ajar berbasis proyek dapat meningkatkan minat siswa dibuktikan dengan hasil tanggapan siswa yang telah melakukan pembelajaran dengan hasil nilai 90% (sangat baik) dan bahan ajar tersebut dapat memudahkan guru dalam pembelajaran dibuktikan dengan rata-rata tanggapan guru 86% (sangat baik).
KEMAMPUAN BERPIKIR KRITIS SISWA MENGGUNAKAN MODEL PROBLEM POSING DAN PROBLEM SOLVING PADA MATERI SISTEM EKSKRESI
Authors: Wartini Titin Sri , Retnowati Rita , Suhardi Eka
Published: January 2020

Penelitian ini merupakan penelitian kuantitatif-eksperimen. Penelitian ini bertujuan untuk mengetahui pengaruh  model problem posing dan problem solving dalam meningkatkan kemampuan berpikir kritis siswa pada pembelajaran materi sistem ekskresi . Penelitian ini dilaksanakan pada bulan Mei 2017. Populasi dalam penelitian ini adalah siswa kelas XI IPA SMA Negeri 1 Cigudeg tahun akademik 2016/2017. Teknik pengumpulan data yang digunakan yaitu menggunakan teknik sampel acak. Sampel untuk kelas eksperimen adalah XI IPA-4 yang diberikan perlakuan model pembelajaran  Problem Posing dengan jumlah 39 orang siswa dan XI IPA-5 diberikan perlakuan dengan model Problem Solving dengan jumlah 38 orang siswa. Rata-rata n-gain  untuk kelas problem posing adalah 68 dan kelas problem solving adalah 64.  Berdasarkan hasil uji t pada taraf signifikansi ɑ = 0,05 diperoleh thitung 2,74 sedangkan ttabel 1,99 sehingga diperoleh thitung >  ttabel, dengan demikian hipotesis nol (H0) ditolak dan hipotesis alternatif (H1) diterima. Berdasarkan hasil penelitian yang telah dilakukan, dapat disimpulkan bahwa pembelajaran dengan model problem posing dan problem solving dapat meningkatkan kemampuan berpikir kritis. Hasil kemampuan berpikir kritis kelompok problem posing lebih baik dibandingkan dengan kelompok kelas problem solving. Kata Kunci: Kemampuan Berpikir Kritis, Problem Posing, Problem Solving.
A Novel Training Program to Improve Human Spatial Orientation: Preliminary Findings
Authors: McLaren-Gradinaru Michael , Burles Ford , Dhillon Inderpreet , Leonidas David Adam , Umiltà Alberto , Hannah Jaimy , Dolhan Kira , Iaria Giuseppe
Published: January 2020

The ability to form a mental representation of the surroundings is a critical skill for spatial navigation and orientation in humans. Such a mental representation is known as a “cognitive map” and is formed as individuals familiarize themselves with the surrounding, providing detailed information about salient environmental landmarks and their spatial relationships. Despite evidence of the malleability and potential for training spatial orientation skills in humans, it remains unknown if the specific ability to form cognitive maps can be improved by an appositely developed training program. Here, we present a newly developed computerized 12-days training program in a virtual environment designed specifically to stimulate the acquisition of this important skill. We asked 15 healthy volunteers to complete the training program and perform a comprehensive spatial behavioral assessment before and after the training. We asked participants to become familiar with the environment by navigating a small area before slowly building them up to navigate within the larger and more complex environment; we asked them to travel back and forth between environmental landmarks until they had built an understanding of where those landmarks resided with respect to one another. This process repeated until participants had visited every landmark in the virtual town and had learned where each landmark resided with respect to the others. The results of this study confirmed the feasibility of the training program and suggested an improvement in the ability of participants to form mental representations of the spatial surrounding. This study provides preliminary findings on the feasibility of a 12-days program in training spatial orientation skills. We discuss the utility and potential impact of this training program in the lives of the many individuals affected by topographical disorientation as a result of an acquired or developmental condition.
Identification of a Two-Gene (PML-EPB41) Signature With Independent Prognostic Value in Osteosarcoma
Authors: Liu Shengye , Liu Jiamei , Yu Xuechen , Shen Tao , Fu Qin
Published: January 2020

Background: Osteosarcoma (OSA) is the most prevalent form of malignant bone cancer and it occurs predominantly in children and adolescents. OSA is associated with a poor prognosis and highest cause of cancer-related death. However, there are a few biomarkers that can serve as reasonable assessments of prognosis.

Methods: Gene expression profiling data were downloaded from dataset GSE39058 and GSE21257 from the Gene Expression Omnibus database as well as TARGET database. Bioinformatic analysis with data integration was conducted to discover the significant biomarkers for predicting prognosis. Verification was conducted by qPCR and western blot to measure the expression of genes.

Results: 733 seed genes were selected by combining the results of the expression profiling data with hub nodes in a human protein-protein interaction network with their gene functional enrichment categories identified. Following by Cox proportional risk regression modeling, a 2-gene (PML-EPB41) signature was developed for prognostic prediction of patients with OSA. Patients in the high-risk group had significantly poorer survival outcomes than in the low-risk group. Finally, the signature was validated and analyzed by the external dataset along with Kaplan–Meier survival analysis as well as biological experiment. A molecular gene model was built to serve as an innovative predictor of prognosis for patients with OSA.

Conclusion: Our findings define novel biomarkers for OSA prognosis, which will possibly aid in the discovery of novel therapeutic targets with clinical applications.