bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables S1-S2 from Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade
Authors: Chen Michelle B. , Lamar John M. , Li Ran , Hynes Richard O. , Kamm Roger D.
Published: March 2023

Sequences of the miR-30-based shRNAs targeting different human (for MDA-MB-231, A-375 MA2, SUM 159) or mouse (for 4T1) integrin subunits used in this study ; 4T1 cells stably expressing miR30-based shRNAs targeting the indicated integrin subunits were assayed at least 3 times by live-cell flow cytometry for surface expression of the indicated integrin .
Supplemental Figures and Tables from A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy
Authors: Makvandi Mehran , Xu Kuiying , Lieberman Brian P. , Anderson Redmond-Craig , Effron Samuel Sander , Winters Harrison D. , Zeng Chenbo , McDonald Elizabeth S. , Pryma Daniel A. , Greenberg Roger A. , Mach Robert H.
Published: March 2023

SI-figure 1: "Chemical synthesis scheme for [125I]KX1." SI-figure 2: "Whole western blots and regions of interest generated around the protein of interest." SI-figure 3: "Kinetic analysis association and dissociation curves of [125I]KX1." SI-table 1: "Summary table for cell lines used in vitro to validate [125I]KX1 as a marker of PARP-1 expression." SI-table 2: "Competitive inhibition (Ki) Values are presented for each PARP inhibitor as measured in the different cell lines." SI-table 3: "Experimental association and dissociation values of [125I]KX1." SI-table 4: "Dissociation constants for [125I]KX1 in multiple cell lines." SI-table 5: " EC50 values for PARP inhibitors in cell lines evaluated."
Supplementary Movie S1 from Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade
Authors: Chen Michelle B. , Lamar John M. , Li Ran , Hynes Richard O. , Kamm Roger D.
Published: March 2023

Time-lapse confocal microscopy (20X) of one representative region of interest with control MDA-MB 231 extravasating (green) from in vitro microvascular networks (HUVEC; red).
Supplemental Figure and Table Legends from A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy
Authors: Makvandi Mehran , Xu Kuiying , Lieberman Brian P. , Anderson Redmond-Craig , Effron Samuel Sander , Winters Harrison D. , Zeng Chenbo , McDonald Elizabeth S. , Pryma Daniel A. , Greenberg Roger A. , Mach Robert H.
Published: March 2023

Legends for supplemental figures and tables
Supplementary Legends from Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade
Authors: Chen Michelle B. , Lamar John M. , Li Ran , Hynes Richard O. , Kamm Roger D.
Published: March 2023

Legend for Supplementary Figures S1-S8, Supplementary Tables S1-S2, and Supplementary Movie S1.
Supplemental Figure Legend from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Authors: Loncle Celine , Bonjoch Laia , Folch-Puy Emma , Lopez-Millan Maria Belen , Lac Sophie , Molejon Maria Inés , Chuluyan Eduardo , Cordelier Pierre , Dubus Pierre , Lomberk Gwen , Urrutia Raul , Closa Daniel , Iovanna Juan L.
Published: March 2023

Legend for Supplemental Figure 1.
Supplementary Material; Supplementary Figures 1 and 2 and Supplementary Table 1 from Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer
Authors: Winner Kimberly R. Kanigel , Steinkamp Mara P. , Lee Rebecca J. , Swat Maciej , Muller Carolyn Y. , Moses Melanie E. , Jiang Yi , Wilson Bridget S.
Published: March 2023

Further details on model assumptions, statistical analysis, and model parameters. Supplementary Figure 1: Vascular Densities in Bowel and Omentum Metastatic Sites for Individual Patients Do Not Correlate. Supplementary Figure 2: Box Plots of Vascular Density in Patient Tumor Samples. Supplementary Table 1: Concentration Fits for IP and IV Compartments.
Supplementary Table 5 and 6 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Authors: Wragg Joseph W. , Finnity Jonathan P. , Anderson Jane A. , Ferguson Henry J.M. , Porfiri Emilio , Bhatt Rupesh I. , Murray Paul G. , Heath Victoria L. , Bicknell Roy
Published: March 2023

Supplementary Table 5: Matrix metallopeptidase regulation across tissue types (Gene expression comparison shown as Log2 fold change) Supplementary Table 6: Collagen regulation across tissue types (Gene expression comparison shown as Log2 fold change)
Supplementary Materials from Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth
Authors: Huang Pao-Hsuan , Chen Mei-Chih , Peng Yu-Ting , Kao Wei-Hsiang , Chang Chih-Hsiang , Wang Yun-Chi , Lai Chih-Ho , Hsieh Jer-Tsong , Wang Jo-Hsin , Lee Yueh-Tsung , Lin Eugene , Yue Chia-Herng , Wang Hsin-Yi , You Shuen-Chi , Lin Ho
Published: March 2023

Antibodies, reagents, and primer sequences.
Supplementary Table S1 from Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer
Authors: Chimote Ameet A. , Hajdu Peter , Sfyris Alexandros M. , Gleich Brittany N. , Wise-Draper Trisha , Casper Keith A. , Conforti Laura
Published: March 2023

Histopathology analysis of Hematoxylin-Eosin stained slides from HNC tumor and normal tissue
Figure S3 from Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability and Sensitivity to the DNA Repair Inhibitor AsiDNA
Authors: Jdey Wael , Thierry Sylvain , Popova Tatiana , Stern Marc-Henri , Dutreix Marie
Published: March 2023

Lack of a correlation between sensitivity of BC cells to AsiDNA and their proliferation rate. Survival (ordinate) was monitored by trypan blue staining and manual counting (10 days after treatment). Survival is expressed as the percentage of living cells relative to non-treated cells (NT). The doubling time (abscissa) was calculated by counting the cells during the 10 days of exponential growth. The correlation analysis between survival in the presence of AsiDNA and doubling time was performed using GraphPadPrism5 software and indicates that there is no significant correlation.
Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues
Authors: Xie Gengqiang , Chen Hanqing , Jia Dongyu , Shu Zhiqiang , Palmer William Hunt , Huang Yi-Chun , Zeng Xiankun , Hou Steven X. , Jiao Renjie , Deng Wu-Min
Published: March 2023

Supplementary Table 1: The mRNA level changes of representative components or targets of JAK-STAT, JNK, and Notch signaling pathways in snr1-RNAi tumorous wing discs relative to control wildtype wing discs.
Table S2 from Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers
Authors: Yau Edwin H. , Kummetha Indrasena Reddy , Lichinchi Gianluigi , Tang Rachel , Zhang Yunlin , Rana Tariq M.
Published: March 2023

Table showing sgRNAs selectively depleted in KRAS mutant xenografts
Figure S2 from Quantitative Whole Genome Sequencing of Circulating Tumor Cells Enables Personalized Combination Therapy of Metastatic Cancer
Authors: Gulbahce Natali , Magbanua Mark Jesus M. , Chin Robert , Agarwal Misha R. , Luo Xuhao , Liu Jia , Hayden Daniel M. , Mao Qing , Ciotlos Serban , Li Zhenyu , Chen Yanxiang , Chen Xingpeng , Li Yuxiang , Zhang Rebecca Yu , Lee Katharine , Tearle Rick , Park Emily , Drmanac Snezana , Rugo Hope S. , Park John W. , Drmanac Radoje , Peters Brock A.
Published: March 2023

Prevalence difference between early and late collection time points. We used allele fraction (prevalence), the ratio of compartments with reads supporting variant calls versus total calls, to further analyze changes between two collection time points, Early and Late. For each variant, prevalence was calculated using cells collected at Early and Late separately. Distribution of the difference between Early and Late prevalence are plotted. The prevalence difference between the two time points indicates whether tumor lineages stayed the same (difference = 0) or increased or decreased. The peak of the distribution is at 0 indicating tumor lineages survived the treatment, which is consistent with a lack of tumor response between these time points.
Supplementary Figure 6 from Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Authors: Borriello Lucia , Nakata Rie , Sheard Michael A. , Fernandez G. Esteban , Sposto Richard , Malvar Jemily , Blavier Laurence , Shimada Hiroyuki , Asgharzadeh Shahab , Seeger Robert C. , DeClerck Yves A.
Published: March 2023

Cytokines and chemokines not up-regulated by NB-MSC interaction and lack of inhibition of STAT3 activation by anti-IL-6/IL-6R
Supplementary Figure 5 from Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Authors: Borriello Lucia , Nakata Rie , Sheard Michael A. , Fernandez G. Esteban , Sposto Richard , Malvar Jemily , Blavier Laurence , Shimada Hiroyuki , Asgharzadeh Shahab , Seeger Robert C. , DeClerck Yves A.
Published: March 2023

CAF-MSC and BM-MSC induce activation of STAT3 and ERK1/2 signaling in NB cells
Supplementary Table 4 from Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Authors: Rodríguez-Hernández Guillermo , Hauer Julia , Martín-Lorenzo Alberto , Schäfer Daniel , Bartenhagen Christoph , García-Ramírez Idoia , Auer Franziska , González-Herrero Inés , Ruiz-Roca Lucia , Gombert Michael , Okpanyi Vera , Fischer Ute , Chen Cai , Dugas Martin , Bhatia Sanil , Linka René Martin , Garcia-Suquia Marta , Rascón-Trincado María Victoria , Garcia-Sanchez Angel , Blanco Oscar , García-Cenador Maria Begoña , García-Criado Francisco Javier , Cobaleda César , Alonso-López Diego , De Las Rivas Javier , Müschen Markus , Vicente-Dueñas Carolina , Sánchez-García Isidro , Borkhardt Arndt
Published: March 2023

Supplementary Table 4: Differentially expressed genes in bone marrow proB and preB cells from ETV6-RUNX1 mice compared to wild-type bone marrow proB and preB cells. (12423 genes-probesets with FDR = 0.1).
Supplementary Figure 4 from Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Authors: Borriello Lucia , Nakata Rie , Sheard Michael A. , Fernandez G. Esteban , Sposto Richard , Malvar Jemily , Blavier Laurence , Shimada Hiroyuki , Asgharzadeh Shahab , Seeger Robert C. , DeClerck Yves A.
Published: March 2023

CAF-MSC and BM-MSC enhance cell viability of NB cells in vitro and protect tumor cells from drug-induced apoptosis in vitro.
Supplementary Tables 1 through 4 from SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor
Authors: Zheng Li-Sheng , Yang Jun-Ping , Cao Yun , Peng Li-Xia , Sun Rui , Xie Ping , Wang Meng-Yao , Meng Dong-Fang , Luo Dong-Hua , Zou Xiong , Chen Ming-Yuan , Mai Hai-Qiang , Guo Ling , Guo Xiang , Shao Jian-Yong , Huang Bi-Jun , Zhang Wei , Qian Chao-Nan
Published: March 2023

Supplementary Table S1. Clinical characteristics of 534 NPC patients. Supplementary Table S2. Sequences used for shRNA construction and siRNAs. Supplementary Table S3. Primers used for real-time PCR. Supplementary Table S4. Association of SPINK6 expression with clinicopathological characteristics of NPC patients.
Supplementary Figures S2-4 from Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Authors: Tschida Barbara R. , Temiz Nuri A. , Kuka Timothy P. , Lee Lindsey A. , Riordan Jesse D. , Tierrablanca Carlos A. , Hullsiek Robert , Wagner Sandra , Hudson Wendy A. , Linden Michael A. , Amin Khalid , Beckmann Pauline J. , Heuer Rachel A. , Sarver Aaron L. , Yang Ju Dong , Roberts Lewis R. , Nadeau Joseph H. , Dupuy Adam J. , Keng Vincent W. , Largaespada David A.
Published: March 2023

Transposon insertion profiles from animals with tumors sharing 0-2(S2), 3(S3), or >3(S4) insertions
Supplementary Figures S11-13 from Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Authors: Tschida Barbara R. , Temiz Nuri A. , Kuka Timothy P. , Lee Lindsey A. , Riordan Jesse D. , Tierrablanca Carlos A. , Hullsiek Robert , Wagner Sandra , Hudson Wendy A. , Linden Michael A. , Amin Khalid , Beckmann Pauline J. , Heuer Rachel A. , Sarver Aaron L. , Yang Ju Dong , Roberts Lewis R. , Nadeau Joseph H. , Dupuy Adam J. , Keng Vincent W. , Largaespada David A.
Published: March 2023

Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
Figure S3 from Resistance to the Antibody–Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity
Authors: Ríos-Luci Carla , García-Alonso Sara , Díaz-Rodríguez Elena , Nadal-Serrano Mercedes , Arribas Joaquín , Ocaña Alberto , Pandiella Atanasio
Published: March 2023

The autophagic process is preserved in T-DM1 resistant clones.
Supplementary Figure 6 from Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Authors: Sierra Rosa A. , Trillo-Tinoco Jimena , Mohamed Eslam , Yu Lolie , Achyut Bhagelu R. , Arbab Ali , Bradford Jennifer W. , Osborne Barbara A. , Miele Lucio , Rodriguez Paulo C.
Published: March 2023

Tumor-derived factors induce the expression of Jagged molecules on MDSCs.
Supplementary Figure 5 from Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Authors: Sierra Rosa A. , Trillo-Tinoco Jimena , Mohamed Eslam , Yu Lolie , Achyut Bhagelu R. , Arbab Ali , Bradford Jennifer W. , Osborne Barbara A. , Miele Lucio , Rodriguez Paulo C.
Published: March 2023

Studies showing the effect of anti-Jagged therapy in adoptive transfer using non-activated antigen specific T cells.
WEHI164 peptidome analysis from Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen
Authors: Probst Philipp , Kopp Janine , Oxenius Annette , Colombo Mario P. , Ritz Danilo , Fugmann Tim , Neri Dario
Published: March 2023

MHC I peptidome RAW data of the WEHI164 cell line
Supplemental Table 2 from NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem–like Cells
Authors: House Carrie D. , Jordan Elizabeth , Hernandez Lidia , Ozaki Michelle , James Jana M. , Kim Marianne , Kruhlak Michael J. , Batchelor Eric , Elloumi Fathi , Cam Margaret C. , Annunziata Christina M.
Published: March 2023

primer sequences for qPCR of NF-kB regulated genes, and for chromatin immunoprecipitation
Supplemental Figure 1 from NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem–like Cells
Authors: House Carrie D. , Jordan Elizabeth , Hernandez Lidia , Ozaki Michelle , James Jana M. , Kim Marianne , Kruhlak Michael J. , Batchelor Eric , Elloumi Fathi , Cam Margaret C. , Annunziata Christina M.
Published: March 2023

RELA Chromatin immunoprecipitation, PCR
Supplementary Table 5 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Authors: Jaeger Samira , Igea Ana , Arroyo Rodrigo , Alcalde Victor , Canovas Begoña , Orozco Modesto , Nebreda Angel R. , Aloy Patrick
Published: March 2023

Overview on the predicted drug combinations together with the pathways mainly involved in crosstalk inhibition (Excel table).
Supplementary Figure S2. from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer
Authors: Elsarraj Hanan S. , Valdez Kelli E. , Hong Yan , Grimm Sandra L. , Ricci Lawrence R. , Fan Fang , Tawfik Ossama , May Lisa , Cusick Therese , Inciardi Marc , Redick Mark , Gatewood Jason , Winblad Onalisa , Hilsenbeck Susan , Edwards Dean P. , Hagan Christy R. , Godwin Andrew K. , Fabian Carol , Behbod Fariba
Published: March 2023

NEMO is required for E+P induced expression of IL-6 and NFkB signaling in ER+PR+ overexpressing DCIS.com breast cancer cells.
Table S4 from A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
Authors: Hou Panpan , Wu Chao , Wang Yuchen , Qi Rui , Bhavanasi Dheeraj , Zuo Zhixiang , Dos Santos Cedric , Chen Shuliang , Chen Yu , Zheng Hong , Wang Hong , Perl Alexander , Guo Deyin , Huang Jian
Published: March 2023

Supplementary Table 4. The antibodies used in this study
Supplementary Figures 1 through 5 and Supplementary Tables 1 through 4 from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Authors: Luo Chunling , Cheng Yuanming , Liu Yuguo , Chen Linlin , Liu Lina , Wei Ning , Xie Zhiqin , Wu Wenwu , Feng Ying
Published: March 2023

Supplementary Fig S1. SRSF2 increases colony-forming efficiencies of hepatocarcinoma cells. Supplementary Fig S2. Exogenous expression of SRSF2 in KD cells restores WT splicing patterns of SRSF2-targeted transcripts. Supplementary Fig S3. Knockdown of SRSF10 and hnRNPK has no obvious effects on the SRSF2-regulated splicing events. Supplementary Fig S4. HCC-related splice variants are examined for their functions in SK-Hep-1 and Huh7 cells. Supplementary Fig S5. Both GCH-L and STK39-L variants are required for cell growth in vitro. Supplementary Fig S6. Overexpression of GCH1-L or STK39-L slightly increases colony-forming efficiencies of SRSF2-depleted cells. Supplementary Table S1: Relationship between expression of SRSF2 in HCC and clinical and pathological features of the individuals. Supplementary Table S2: Summary of RNA-seq data mapping results. Supplementary Table S3: Relationship between ratios of GCH1-E6(IN/EX) in HCC and clinical and pathological features of the individuals from TCGA database. Supplementary Table S4: Relationship between expression of SRSF2 in HCC and clinical and pathological features of the individuals from TCGA database.
Figure S4 from TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer
Authors: Cooper Jonathan M. , Ou Yi-Hung , McMillan Elizabeth A. , Vaden Rachel M. , Zaman Aubhishek , Bodemann Brian O. , Makkar Gurbani , Posner Bruce A. , White Michael A.
Published: March 2023

Figure S4 shows that modulation of mesenchymal status is sufficient to alter Ras-Mutant NSCLC sensitivity to TBK1 inhibitors
Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy
Authors: Huang Wen-Yen , Lai Shih-Fan , Chiu Hsien-Yi , Chang Michael , Plikus Maksim V. , Chan Chih-Chieh , Chen You-Tzung , Tsao Po-Nien , Yang Tsung-Lin , Lee Hsuan-Shu , Chi Peter , Lin Sung-Jan
Published: March 2023

Figure S1. Hair cycles and disruption and restoration of differentiation in anagen HFs after IR. Figure S2. Comparison of apoptosis and DNA damage response of K5+ and K5negative cells in the hair matrix. Figure S3. Immunofluorescent comparison of lower tip cells of the epithelial strand at 72hrs after 5.5Gy of IR with BgSCs and ShgSCs and cell sorting. Figure S4. Lineage tracing of Lgr5+ cells after 5.5Gy of IR. Figure S5. WNT signaling after 2Gy of IR. Figure S6. Histology, apoptosis and cell proliferation in p53 null mice after 2Gy of IR, and the effect of Wnt3a treatment on HF differentiation. Figure S7. Effect of Wnt3a treatment on HFs after 5.5Gy of IR. Table S1. Antibodies used in immunostaining. Table S2. Primer sequences for quantitative RT-PCR. Table S3. Pathways significantly affected in the epithelial cells after 5.5Gy of IR.
Supplementary figure legend from Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion
Authors: Liu Yongqiang , Yuelling Larra W. , Wang Yuan , Du Fang , Gordon Renata E. , O'Brien Jenny A. , Ng Jessica M.Y. , Robins Shannon , Lee Eric H. , Liu Hailong , Curran Tom , Yang Zeng-Jie
Published: March 2023

Legend for supplementary figures
Figure S1 from Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target
Authors: New Jacob , Arnold Levi , Ananth Megha , Alvi Sameer , Thornton Mackenzie , Werner Lauryn , Tawfik Ossama , Dai Hongying , Shnayder Yelizaveta , Kakarala Kiran , Tsue Terance T. , Girod Douglas A. , Ding Wen-Xing , Anant Shrikant , Thomas Sufi Mary
Published: March 2023

CAFs exhibit increased LC3 puncta per cell compared to NF.
Supplementary figure S5 from Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy
Authors: Ahmad Shamim , Abu-Eid Rasha , Shrimali Rajeev , Webb Mason , Verma Vivek , Doroodchi Atbin , Berrong Zuzana , Samara Raed , Rodriguez Paulo C. , Mkrtichyan Mikayel , Khleif Samir N.
Published: March 2023

The inhibition of PI3KÎ± or PI3KÎ² does not block the proliferation of Tregs and Tconvs
Supplementary figure S3 from Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy
Authors: Ahmad Shamim , Abu-Eid Rasha , Shrimali Rajeev , Webb Mason , Verma Vivek , Doroodchi Atbin , Berrong Zuzana , Samara Raed , Rodriguez Paulo C. , Mkrtichyan Mikayel , Khleif Samir N.
Published: March 2023

The inhibition of PI3KÎ± or PI3KÎ² does not block the activation of Akt in Tregs and Tconvs
Combination Therapy Treated Mouse Video from Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response
Authors: Larimer Benjamin M. , Wehrenberg-Klee Eric , Dubois Frank , Mehta Anila , Kalomeris Taylor , Flaherty Keith , Boland Genevieve , Mahmood Umar
Published: March 2023

Rotating Maximum Intensity Projection Video of Mouse Treated with Anti-PD-1 and CTLA-4 Therapy
Figure S4 from miR-519d Promotes Melanoma Progression by Downregulating EphA4
Authors: Hua Kuo-Tai , Hong Jin-Bong , Sheen Yi-Shuan , Huang Hsin-Yi , Huang Yi-Ling , Chen Jau-Shiuh , Liao Yi-Hua
Published: March 2023

Suppl. Figure 4. Upregulation of miR-519d and reciprocal downregulation of EphA4 in melanospheres. A, Quantitative RT-PCR analyses of miR-519d expression in SK-Mel-28 and Sk-Mel-90 adherent and sphere-forming cells. B, Decreased EphA4 expression level in sphere-forming cells, compared to the adherent cells. **, P < 0.01.
Supporting Information: Table S1, S2, S3; Figure S1 from TLR4-Mediated Inflammation Promotes KSHV-Induced Cellular Transformation and Tumorigenesis by Activating the STAT3 Pathway
Authors: Gruffaz Marion , Vasan Karthik , Tan Brandon , Ramos da Silva Suzane , Gao Shou-Jiang
Published: March 2023

Table S1: Sequences of primers used for RT-qPCR. Table S2: Sequences of siRNAs. Table S3:Sequences of shRNAs Figure S1: TLR4 is upregulated in human Kaposi''s sarcoma tumors.
Supplemental figure 2 from YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor–Induced Activation of the PI3K Pathway
Authors: Wang Chao , Gu Chao , Jeong Kang Jin , Zhang Dong , Guo Wei , Lu Yiling , Ju Zhenlin , Panupinthu Nattapon , Yang Ji Yeon , Gagea Mihai (Mike) , Ng Patrick Kwok Shing , Zhang Fan , Mills Gordon B.
Published: March 2023

GAB2 mRNA is markedly altered by siYAP/TAZ
Supplementary Figure 6 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis
Authors: Nandana Srinivas , Tripathi Manisha , Duan Peng , Chu Chia-Yi , Mishra Rajeev , Liu Chunyan , Jin Renjie , Yamashita Hironobu , Zayzafoon Majd , Bhowmick Neil A. , Zhau Haiyen E. , Matusik Robert J. , Chung Leland W.K.
Published: March 2023

Schematic depiction of WNT3A gene promoter, and ChIP analysis of LNCaP-TBX2 and LNCaP-Neo cells to assess the binding of TBX2 on WNT3A promoter
Supplementary Figure 3 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis
Authors: Nandana Srinivas , Tripathi Manisha , Duan Peng , Chu Chia-Yi , Mishra Rajeev , Liu Chunyan , Jin Renjie , Yamashita Hironobu , Zayzafoon Majd , Bhowmick Neil A. , Zhau Haiyen E. , Matusik Robert J. , Chung Leland W.K.
Published: March 2023

Invasion assay of ARCaPM-TBX2 and ARCaPM-Neo cells
Supplementary Materials and Methods from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling
Authors: Josephs Debra H. , Bax Heather J. , Dodev Tihomir , Georgouli Mirella , Nakamura Mano , Pellizzari Giulia , Saul Louise , Karagiannis Panagiotis , Cheung Anthony , Herraiz Cecilia , Ilieva Kristina M. , Correa Isabel , Fittall Matthew , Crescioli Silvia , Gazinska Patrycja , Woodman Natalie , Mele Silvia , Chiaruttini Giulia , Gilbert Amy E. , Koers Alexander , Bracher Marguerite , Selkirk Christopher , Lentfer Heike , Barton Claire , Lever Elliott , Muirhead Gareth , Tsoka Sophia , Canevari Silvana , Figini Mariangela , Montes Ana , Downes Noel , Dombrowicz David , Corrigan Christopher J. , Beavil Andrew J. , Nestle Frank O. , Jones Paul S. , Gould Hannah J. , Sanz-Moreno Victoria , Blower Philip J. , Spicer James F. , Karagiannis Sophia N.
Published: March 2023

Description of additional experiments and procedures carried out in this study
Supplementary Figure S2 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling
Authors: Josephs Debra H. , Bax Heather J. , Dodev Tihomir , Georgouli Mirella , Nakamura Mano , Pellizzari Giulia , Saul Louise , Karagiannis Panagiotis , Cheung Anthony , Herraiz Cecilia , Ilieva Kristina M. , Correa Isabel , Fittall Matthew , Crescioli Silvia , Gazinska Patrycja , Woodman Natalie , Mele Silvia , Chiaruttini Giulia , Gilbert Amy E. , Koers Alexander , Bracher Marguerite , Selkirk Christopher , Lentfer Heike , Barton Claire , Lever Elliott , Muirhead Gareth , Tsoka Sophia , Canevari Silvana , Figini Mariangela , Montes Ana , Downes Noel , Dombrowicz David , Corrigan Christopher J. , Beavil Andrew J. , Nestle Frank O. , Jones Paul S. , Gould Hannah J. , Sanz-Moreno Victoria , Blower Philip J. , Spicer James F. , Karagiannis Sophia N.
Published: March 2023

Set up of the tumor-bearing surrogate rat model
Supplementary Materials and Methods from Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop
Authors: Li Ting , Guo Hanqing , Zhao Xiaodi , Jin Jiang , Zhang Lifeng , Li Hong , Lu Yuanyuan , Nie Yongzhan , Wu Kaichun , Shi Yongquan , Fan Daiming
Published: March 2023

Supplementary Materials and Methods
Figure S8 from Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop
Authors: Li Ting , Guo Hanqing , Zhao Xiaodi , Jin Jiang , Zhang Lifeng , Li Hong , Lu Yuanyuan , Nie Yongzhan , Wu Kaichun , Shi Yongquan , Fan Daiming
Published: March 2023

Knockdown of CypB through independent shRNA inhibited GC growth.
Supplemental Materials and Methods from Armed Oncolytic Adenovirus–Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors
Authors: Tanoue Kiyonori , Rosewell Shaw Amanda , Watanabe Norihiro , Porter Caroline , Rana Bhakti , Gottschalk Stephen , Brenner Malcolm , Suzuki Masataka
Published: March 2023

Supplemental Materials and Methods
Supplementary Table S1-S3 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
Authors: Alfaqih Mahmoud A. , Nelson Erik R. , Liu Wen , Safi Rachid , Jasper Jeffery S. , Macias Everardo , Geradts Joseph , Thompson J. Will , Dubois Laura G. , Freeman Michael R. , Chang Ching-yi , Chi Jen-Tsan , McDonnell Donald P. , Freedland Stephen J.
Published: March 2023

Table S1. CYP27A1 transcript is down-regulated in primary prostate tumors. Table S2. CYP27A1 transcript is down-regulated in metastatic PC relative to primary tumors. Table S3. CYP27A1 transcript levels in hormone sensitive PC relative to hormone resistant PC
Supplementary Figure S6 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
Authors: Alfaqih Mahmoud A. , Nelson Erik R. , Liu Wen , Safi Rachid , Jasper Jeffery S. , Macias Everardo , Geradts Joseph , Thompson J. Will , Dubois Laura G. , Freeman Michael R. , Chang Ching-yi , Chi Jen-Tsan , McDonnell Donald P. , Freedland Stephen J.
Published: March 2023

Inhibition/downregulation of SREBP2/LDLR axis inhibits PC cell growth
Supplementary Figure S5 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
Authors: Alfaqih Mahmoud A. , Nelson Erik R. , Liu Wen , Safi Rachid , Jasper Jeffery S. , Macias Everardo , Geradts Joseph , Thompson J. Will , Dubois Laura G. , Freeman Michael R. , Chang Ching-yi , Chi Jen-Tsan , McDonnell Donald P. , Freedland Stephen J.
Published: March 2023

CYP27A1/27HC axis inhibits growth of PC cells via depletion of cellular cholesterol
Supplementary Table S4 from Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination
Authors: van Oorschot Bregje , Uitterhoeve Lon , Oomen Ilja , ten Cate Rosemarie , Medema Jan Paul , Vrieling Harry , Stalpers Lukas J.A. , Moerland Perry D. , Franken Nicolaas A.P.
Published: March 2023

Differential response to irradiation between Grade 3 and Grade 0 patients for the probesets part of the HR geneset.
Supplementary Tables from Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E
Authors: Joyce Cailin E. , Yanez Adrienne G. , Mori Akihiro , Yoda Akinori , Carroll Johanna S. , Novina Carl D.
Published: March 2023

This file contains supplementary tables with differentially expressed proteins (Table S1) and mRNAs (Table S3), gene set enrichments (Table S2) and a comparative analysis with earlier studies of eIF4F targets (Table S4).
Supplementary Fig 4 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Authors: Ding Ling-Wen , Sun Qiao-Yang , Tan Kar-Tong , Chien Wenwen , Thippeswamy Anand Mayakonda , Eng Juh Yeoh Allen , Kawamata Norihiko , Nagata Yasunobu , Xiao Jin-Fen , Loh Xin-Yi , Lin De-Chen , Garg Manoj , Jiang Yan-Yi , Xu Liang , Lim Su-Lin , Liu Li-Zhen , Madan Vikas , Sanada Masashi , Fernández Lucia Torres , Preethi Hema , Lill Michael , Kantarjian Hagop M. , Kornblau Steven M. , Miyano Satoru , Liang Der-Cherng , Ogawa Seishi , Shih Lee-Yung , Yang Henry , Koeffler H. Phillip
Published: March 2023

Supplementary Fig. 4. p53 pathway is dysregulated in ALL.
Supplementary Fig 3 from Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Authors: Ding Ling-Wen , Sun Qiao-Yang , Tan Kar-Tong , Chien Wenwen , Thippeswamy Anand Mayakonda , Eng Juh Yeoh Allen , Kawamata Norihiko , Nagata Yasunobu , Xiao Jin-Fen , Loh Xin-Yi , Lin De-Chen , Garg Manoj , Jiang Yan-Yi , Xu Liang , Lim Su-Lin , Liu Li-Zhen , Madan Vikas , Sanada Masashi , Fernández Lucia Torres , Preethi Hema , Lill Michael , Kantarjian Hagop M. , Kornblau Steven M. , Miyano Satoru , Liang Der-Cherng , Ogawa Seishi , Shih Lee-Yung , Yang Henry , Koeffler H. Phillip
Published: March 2023

Supplementary Fig. 3. CTCF is a potential tumor suppressor.
Supplemental Table and Figure Legend from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Authors: Wei Xiaowei , Xu Yong , Xu Fang Fang , Chaiswing Luksana , Schnell David , Noel Teresa , Wang Chi , Chen Jinfei , St. Clair Daret K. , St. Clair William H.
Published: March 2023

Legends for Supplemental Table S1 and Supplemental Figures S1-S3.
Supplementary Fig. 4 from A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors
Authors: Verginadis Ioannis I. , Kanade Rahul , Bell Brett , Koduri Sravya , Ben-Josef Edgar , Koumenis Constantinos
Published: March 2023

Supplementary Fig. 4 - Harvesting and processing of intestinal tissue segments for analysis of inflammatory response.
Supplementary Table 3 from Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma
Authors: Walter David M. , Venancio Olivia S. , Buza Elizabeth L. , Tobias John W. , Deshpande Charuhas , Gudiel A. Andrea , Kim-Kiselak Caroline , Cicchini Michelle , Yates Travis J. , Feldser David M.
Published: March 2023

Supplementary Table 3: Gene ontology analysis for genes deregulated by both Arid1a and Setd2 loss.
Supplementary Table S1 from Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers
Authors: Choy Lisa , Hagenbeek Thijs J. , Solon Margaret , French Dorothy , Finkle David , Shelton Amy , Venook Rayna , Brauer Matthew J. , Siebel Christian W.
Published: March 2023

Gene lists related to Fig. 6B. X axis = anti-N3.A4 vs. anti-gD; Y axis = DAPT vs. DMSO.
Supplementary tables from PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
Authors: Li Jiangmei , Gao Zhen , Zhao Dan , Zhang Lunfeng , Qiao Xinhua , Zhao Yingying , Ding Hong , Zhang Panpan , Lu Junyan , Liu Jia , Jiang Hualiang , Luo Cheng , Chen Chang
Published: March 2023

suppl. table 1chemical structures and activity of representative PI-93 analogues;suppl.table 2. activity and Tm of the PI4KIIα inhibitors;Suppl. Fig.3. Direct interaction between PI-273 analogs and PI4KIIα;Suppl. Fig. 4. PI-273 resistance screens using CRISPR-Cas9;Suppl. Fig.5. Generate and identify PI4KIIα knock out MCF-7 cells;Suppl. Fig. 6. Effects of PI-273 and its analogs on PI4KIIα downstream signaling pathways;Suppl. Fig. 7. PI4KIIα is required for the regulation of PI-273 on signaling transduction in breast cancer cells;Suppl. Fig. 8. PI-273 inhibits the proliferation of breast cancer cells.;Suppl. Fig. 9 Anti-tumor effect of PI-273 in an MCF-7-induced xenograft model;Suppl. Fig. 10 Inhibitory effect of 100 μM PIK inhibitors on PI4KIIα.
Supplemental Table S1 from MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL
Authors: Zhou Mi , Zhou Kuangguo , Cheng Ling , Chen Xing , Wang Jue , Wang Xiao-Min , Zhang Yingchi , Yu Qilin , Zhang Shu , Wang Di , Huang Liang , Huang Mei , Ma Ding , Cheng Tao , Wang Cong-Yi , Yuan Weiping , Zhou Jianfeng
Published: March 2023

This table shows the sequences of primers used in qâ€'PCR.
Supplementary Methods and References from Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors
Authors: Steinberg Shannon M. , Shabaneh Tamer B. , Zhang Peisheng , Martyanov Viktor , Li Zhenghui , Malik Brian T. , Wood Tamara A. , Boni Andrea , Molodtsov Aleksey , Angeles Christina V. , Curiel Tyler J. , Whitfield Michael L. , Turk Mary Jo
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure S7 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells
Authors: Liu Chungang , Liu Limei , Chen Xuejiao , Cheng Jiamin , Zhang Heng , Zhang Chengcheng , Shan Juanjuan , Shen Junjie , Qian Cheng
Published: March 2023

Phenotype of isolated primary HCC associated fibroblasts.
Supplemental Tables from Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα+ Mammary Carcinomas
Authors: Shea Michael P. , O'Leary Kathleen A. , Fakhraldeen Saja A. , Goffin Vincent , Friedl Andreas , Wisinski Kari B. , Alexander Caroline M. , Schuler Linda A.
Published: March 2023

Supplemental Tables 1 and 2
Supplemental Figures S1-S5 from Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα+ Mammary Carcinomas
Authors: Shea Michael P. , O'Leary Kathleen A. , Fakhraldeen Saja A. , Goffin Vincent , Friedl Andreas , Wisinski Kari B. , Alexander Caroline M. , Schuler Linda A.
Published: March 2023

This file contains additional technical detail (antibodies used, gating strategy for FACS) and additional experimental data to complement that shown in the main figures.
Movie 6 from Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies
Authors: Gallaher Jill A. , Enriquez-Navas Pedro M. , Luddy Kimberly A. , Gatenby Robert A. , Anderson Alexander R.A.
Published: March 2023

Comparing CT, AT1, and AT2 treatment schedules for a heterogeneous sensitive tumor when phenotypes can drift. Tumors were initialized by a normal distribution with a mean sensitivity s=80% and standard deviation Ïƒs=25%.
Figure S3 from Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis
Authors: Singh Priyanka , Jenkins Laura M. , Horst Ben , Alers Victoria , Pradhan Shrikant , Kaur Prabhjot , Srivastava Tapasya , Hempel Nadine , Győrffy Balázs , Broude Eugenia V. , Lee Nam Y. , Mythreye Karthikeyan
Published: March 2023

Tube formation of HMEC-1 cells (i)using two independent sources of recombinant Inhibin A: A I (Sigma Aldrich) and A II (R & D Systems) or (ii) in the presence and absence of recombinant 300 pM Inhibin A alone or with anti-Inhibinα antibody (10 µg/ml, monoclonal #sc365439, Santa Cruz). Quantitation of number of meshes as described in Methods. ***P<0.01.
Supplementary Table 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells
Authors: Zhang Kai , Guo Yanjing , Wang Xue , Zhao Huifang , Ji Zhongzhong , Cheng Chaping , Li Li , Fang Yuxiang , Xu Dawei , Zhu Helen He , Gao Wei-Qiang
Published: March 2023

Supplementary Table 1: Antibodies and proteins used in the present study
Supplemental Table 1 from Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers
Authors: Zhang Jialing , Chen Tony , Yang Xinping , Cheng Hui , Späth Stephan S. , Clavijo Paul E. , Chen Jianhong , Silvin Christopher , Issaeva Natalia , Su Xiulan , Yarbrough Wendell G. , Annunziata Christina M. , Chen Zhong , Van Waes Carter
Published: March 2023

Characteristics Cell lines
Supplementary Fig 1 related to Fig 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells
Authors: Zhang Kai , Guo Yanjing , Wang Xue , Zhao Huifang , Ji Zhongzhong , Cheng Chaping , Li Li , Fang Yuxiang , Xu Dawei , Zhu Helen He , Gao Wei-Qiang
Published: March 2023

Supplementary Fig 1 related to Fig 1: hTERT expression in PCa specimens and FACS sorted hTERT-/low and hTERThigh PCa cells
Table S8 from A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer
Authors: Zhang Bo , Chen Men-Yun , Shen Yu-Jun , Zhuo Xian-Bo , Gao Ping , Zhou Fu-Sheng , Liang Bo , Zu Jun , Zhang Qin , Suleman Sufyan , Xu Yi-Hui , Xu Min-Gui , Xu Jin-Kai , Liu Chen-Cheng , Giannareas Nikolaos , Xia Ji-Han , Zhao Yuan , Huang Zhong-Lian , Yang Zhen , Cheng Huai-Dong , Li Na , Hong Yan-Yan , Li Wei , Zhang Min-Jun , Yu Ke-Da , Li Guoliang , Sun Meng-Hong , Chen Zhen-Dong , Wei Gong-Hong , Shao Zhi-Min
Published: March 2023

Biological processes significantly over-represented (P<0.05) among risk loci in Breast Cancer.
Figure S5 from Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis
Authors: Sarvi Sana , Patel Hitesh , Li Jun , Dodd Georgia L. , Creedon Helen , Muir Morwenna , Ward Jocelyn , Dawson John C. , Lee Martin , Culley Jayne , Salter Donald M. , Sims Andrew H. , Byron Adam , Brunton Valerie G.
Published: March 2023

Figure S5 provides supportiung evidence that tumor cell adhesion to VCAM-1 and endothelial cells is integrin alpha4 dependent
Supplementary Figures S1-6 from Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer
Authors: Jansen Valerie M. , Bhola Neil E. , Bauer Joshua A. , Formisano Luigi , Lee Kyung-Min , Hutchinson Katherine E. , Witkiewicz Agnieszka K. , Moore Preston D. , Estrada Mónica Valéria , Sánchez Violeta , Ericsson Paula G. , Sanders Melinda E. , Pohlmann Paula R. , Pishvaian Michael J. , Riddle David A. , Dugger Teresa C. , Wei Wenyi , Knudsen Erik S. , Arteaga Carlos L.
Published: March 2023

Supplementary Figure S1. RNAi screen to identify kinases that sensitize cells to CDK4/6 inhibition. Supplementary Figure S2. Calculation of the sensitivity index (SI) value. Supplementary Figure S3. PDK1 and CDK4/6 inhibitors are synergistic against a panel of cancer cell lines. Supplementary Figure S4. Inhibition of the PI3K/PDK1 pathway results in durable responses and is well-tolerated in vivo. Supplementary Figure S5. Ribociclib-resistant cells are cross-resistant to other CDK4/6 inhibitors and upregulate P-PDK1. Supplementary Figure S6. Inhibition of PI3K/PDK1/AKT/mTOR signaling pathway resensitizes ribociclib-resistant cells to CDK4/6 inhibition.
Supplementary Material and Methods ; Supplementary Figures 1-8; Supplementary Table 1 from Intratumoral CpG-B Promotes Antitumoral Neutrophil, cDC, and T-cell Cooperation without Reprograming Tolerogenic pDC
Authors: Humbert Marion , Guery Leslie , Brighouse Dale , Lemeille Sylvain , Hugues Stephanie
Published: March 2023

Supplementary Data Supplementary Material and Methods: Tumor experiments; CpG-B toxicity in vitro assay; Effect of i.t. CpG-B treatment on the growth of a distal tumor; Reactive oxygen species (ROS) detection. Supplementary Figures: Supplementary Figure 1 shows that CpG-B does not impact EG7 cell growth in vitro; Supplementary Figure 2 depicts that intratumoral CpG-B{plus minus}OVAII administration of B16-OVA tumors significantly inhibits tumor growth; Supplementary Figure 3 illustrates that 5 days following intratumoral CpG-B{plus minus}OVAII administration, EG7 tumor growth is inhibited, anti-tumor T cell responses are not changed in LNs, and the growth of distal EG7 tumors is slightly reduced; Supplementary Figure 4 demonstrates that intratumoral CpG-B{plus minus}HY administration of MCA-101-Dby inhibits tumor growth and promote anti-tumor T cell immunity; Supplementary Figure 5 assesses the efficacy of pDC depletion in tumors from BDCA2-DTR mice injected with diphtheria toxin (DT); Supplementary Figure 6 shows that intratumoral CpG-B{plus minus}OVAII administration inhibits EG7 tumor growth in IFNAR-/- mice; Supplementary Figure 7 shows that CpG-B does not affect the phenotype and the function of tumor-associated neutrophils; Supplementary Figure 8 assesses the efficacy of neutrophil depletion in tumors following the injection of anti-Ly6G antibodies, and the impact on EG7 tumor weight. Supplementary Table Supplementary Table 1 shows the list of genes that are differentially expressed by tumor-associated cDC and/or tumor-associated pDC following intratumoral CpG-B administration. Genes were classified into 3 categories: Ag presentation-related genes, Immunogenicity-related genes, DC migration-related genes.
Supplemental Movie 3: Interstitial convection and vascular perfusion in an LS174T tumor from Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI
Authors: Walker-Samuel Simon , Roberts Thomas A. , Ramasawmy Rajiv , Burrell Jake S. , Johnson Sean Peter , Siow Bernard M. , Richardson Simon , Gonçalves Miguel R. , Pendse Douglas , Robinson Simon P. , Pedley R. Barbara , Lythgoe Mark F.
Published: March 2023

Supplemental Movie 3: Animated EVAC streamlines (grey lines), showing the path taken by interstitial fluid, overlaid on vascular perfusion measurements (colour scale, measured in vivo using arterial spin labelling) and the location of blood vessels (yellow structures, measured ex vivo using micro-CT). The data were acquired in an LS174T colorectal carcinoma tumour xenograft.
Supplemental Movie 2: Interstitial convection, vascular perfusion and the location of blood vessels in an LS174T tumor from Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI
Authors: Walker-Samuel Simon , Roberts Thomas A. , Ramasawmy Rajiv , Burrell Jake S. , Johnson Sean Peter , Siow Bernard M. , Richardson Simon , Gonçalves Miguel R. , Pendse Douglas , Robinson Simon P. , Pedley R. Barbara , Lythgoe Mark F.
Published: March 2023

Supplemental Movie 2: Animated EVAC streamlines (grey lines), showing the path taken by interstitial fluid, overlaid on vascular perfusion measurements (colour scale, measured in vivo using arterial spin labelling) and the location of blood vessels (yellow structures, measured ex vivo using micro-CT). The data were acquired in an LS174T colorectal carcinoma tumour xenograft.
Table S4 from Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
Authors: Niklasson Mia , Maddalo Gianluca , Sramkova Zuzana , Mutlu Ercan , Wee Shimei , Sekyrova Petra , Schmidt Linnéa , Fritz Nicolas , Dehnisch Ivar , Kyriatzis Gregorios , Krafcikova Michaela , Carson Brittany B. , Feenstra Jennifer M. , Marinescu Voichita D. , Segerman Anna , Haraldsson Martin , Gustavsson Anna-Lena , Hammarström Lars G.J. , Jenmalm Jensen Annika , Uhrbom Lene , Altelaar A.F. Maarten , Linnarsson Sten , Uhlén Per , Trantirek Lukas , Vincent C. Theresa , Nelander Sven , Enger Per Øyvind , Andäng Michael
Published: March 2023

Proteomics and phosphoproteomics data analyses I
Tables S1, S4 from Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Authors: Shao Wenlin , Mishina Yuji M. , Feng Yun , Caponigro Giordano , Cooke Vesselina G. , Rivera Stacy , Wang Yingyun , Shen Fang , Korn Joshua M. , Mathews Griner Lesley A. , Nishiguchi Gisele , Rico Alice , Tellew John , Haling Jacob R. , Aversa Robert , Polyakov Valery , Zang Richard , Hekmat-Nejad Mohammad , Amiri Payman , Singh Mallika , Keen Nicholas , Dillon Michael P. , Lees Emma , Ramurthy Savithri , Sellers William R. , Stuart Darrin D.
Published: March 2023

Table S1: Kinase hits from KinomeScan panel. Table S4: Antiproliferative activity of RAF709 in a Ba/F3 cell kinase panel.
Supplemental table S1 from Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis
Authors: Valerio Daria G. , Xu Haiming , Chen Chun-Wei , Hoshii Takayuki , Eisold Meghan E. , Delaney Christopher , Cusan Monica , Deshpande Aniruddha J. , Huang Chun-Hao , Lujambio Amaia , Zheng YuJun George , Zuber Johannes , Pandita Tej K. , Lowe Scott W. , Armstrong Scott A.
Published: March 2023

RNAi screen data summary
Supplementary Data from Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II
Authors: Yu Guoyu , Cheng Chien-Jui , Lin Song-Chang , Lee Yu-Chen , Frigo Daniel E. , Yu-Lee Li-Yuan , Gallick Gary E. , Titus Mark A. , Nutt Leta K. , Lin Sue-Hwa
Published: March 2023

This file contains immunofluorescence of LNCaP, C4-2B4, PC3, and PC3-mm2 PCa cell lines (Supplementary Fig.S1); Immunohistochemistry for the expression of pCaMKII (T286) in specimens from human primary prostate tumor, lymph node metastasis, and bone metastasis (Supplementary Fig. S2); Re-expression of constitutively active CaMKII in PC3-mm2 cells with knockout of CaMKII (Supplementary Fig. S3); Effect of re-expression of constitutively active CaMKII in PC3-mm2 cells with knockout of CaMKII on prostate cancer metastasis (Supplementary Fig. S4); Knockdown of AcoxI in PC3-mm2 cells (Supplementary Fig. S5); Effect of AcoxI-III knockout on the levels of individuallipid components (Supplementary Fig. S6) and Sequence of primers and gDNA of CaMKII and ACOX (Table S1).
Supplemental Dataset A - IDH1-R132H effect on the metabolome. from Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Authors: Waitkus Matthew S. , Pirozzi Christopher J. , Moure Casey J. , Diplas Bill H. , Hansen Landon J. , Carpenter Austin B. , Yang Rui , Wang Zhaohui , Ingram Brian O. , Karoly Edward D. , Mohney Robert P. , Spasojevic Ivan , McLendon Roger E. , Friedman Henry S. , He Yiping , Bigner Darell D. , Yan Hai
Published: March 2023

Metabolomics analysis of IDH1-R132H expression in gliomagenic neural progenitor cells.