bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Internalized Shame and Loneliness in Middle-aged Women: The Mediating Effect of Self-Silencing and Emotional Clarity
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Chang Eun Kyung , Lee Su Lim
Published: March 2024

Objectives The purpose of this study was to examine the relationship among internalized shame, self-silencing, emotional clarity, and loneliness in middle-aged women and to verify the mediating effects of self-silencing and emotional clarity on the relationship between internalized shame and loneliness.
Methods To this end, a survey was conducted on 403 middle-aged women between the ages of 40 and 60, and 399 copies were used for analysis. Technical statistics and correlation analysis were conducted on the collected data using SPSS and AMOS 22.0, and structural equation model analysis was conducted. In addition, the mediated model was verified through bootstrapping.
Results The results of this study are as follows. Firstly, there were significant positive correlations among internalized shame, self-silencing, and loneliness. But, emotional clarity had negative correlations with the aforementined variables. Second, there was a partial mediating effect of self-silencing and emotional clarity in the relationship between internalized shame and loneliness. Third, there was a sequential mediating effect of self-silencing and emotional clarity in the relationship between internalized shame and loneliness.
Conclusions This study is significant in that it not only improved the understanding of loneliness in middle-aged women by revealing the intermediate mechanisms of self-silencing and emotional clarity in the relationship between internalized shame and loneliness, but also provided an effective theoretical basis for counseling intervention.
An Exploratory Study on The Direction of Developing A Self-evaluation Tool for Early Childhood Education Curriculum Operation through Focus Group Interviews
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Kang-Hoon
Published: March 2024

Objectives The purpose of this study is to explore the direction of development of a self-evaluation tool for early childhood education curriculum operation and establish evaluation criteria through focus group interviews.
Methods For this purpose, a focus group interview questionnaire was created based on the results of literature research and big data analysis, and focus group interviews were conducted with six participants consisting of an early childhood education expert (professor), an early childhood education field expert (director), and an early childhood education field expert (teacher). The collected data was analyzed using open coding and constant comparison analysis methods created by Glaser and Strauss.
Results The results of this study were as follows: It was found that the self-evaluation tool for early childhood curriculum operation needs to be developed as a self-evaluation tool for early childhood curriculum operation based on a strengths-based evaluative approach. In addition, it was found that there was a need to establish a minimum evaluation standard by extracting common elements for various evaluation areas shown in the national-level early childhood education curriculum institutional evaluation and covering only essential contents for quality management of early childhood education curriculum operation.
Conclusions Based on the results of this study, it was possible to confirm not only the necessity and expected effects of developing a self-evaluation tool for early childhood curriculum operation based on a strengths-based evaluative approach but also the direction of development of a self-evaluation tool for early childhood curriculum operation based on a strengths-based evaluative approach.
Analysis of the Educational Needs of Professors for Utilizing Generative Artificial Intelligence in University classes: Focusing on K University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Ju-Yeon , Nam Yeong-Ok , Chai So-Lin
Published: March 2024

Objectives The purpose of this study is to analyze the educational needs of professors for the educational use of generative AI in universities.
Methods Data from 126 professors at K University in Seoul were collected online. The prioritization of educational needs in instructional design, teaching methods, and class evaluation areas was determined through reliability analysis, factor analysis, paired-sample T-tests, Borich's Needs Assessment, and The Locus for Focus Model.
Results Among the areas of instructional design, teaching methods, and class evaluation, instructional design emerged as the highest in educational needs. Subfactors revealed that in instructional design, the ‘development of instructional materials’ and the ‘organization of instructional content’ were prioritized. In teaching methods, ‘project-based learning’ and ‘team-based learning’ took precedence. In class evaluation, ‘report assessment’ and ‘descriptive assessment’ rankings were high.
Conclusions To enhance the integration of generative AI in university classes, prioritized support in the field of instructional design is essential. Specific support measures are proposed based on the research findings.
Effects of digital literacy and communication competency on clinical competency in nursing students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Joon-Young , Ha Young-Sun , Kim Mi-Han
Published: March 2024

Objectives A cross-sectional descriptive design was aimed at investigating the level of digital literacy, communication competency and clinical competency in nursing students with a focus on digital literacy as required for future. This study was conducted to identify the factors influencing digital literacy and communication competency with respect to the clinical competency in nursing students.
Methods Data were collected between November and December 2022 from 147 nursing students at a university located in K City, and were analyzed using descriptive statistics, two-sample t-test, one-way ANOVA, and hierarchial multiple regression with the SPSS 29.0 program.
Results The results showed that nursing students generally have good digital literacy, but they struggle with specific areas like material development and information evaluation. Nursing students' communication competency(β =.68, p<.001), followed by digital literacy(β=.19, p=.027) had a significant impact on clinical competency(F=61.9, p< .001), as explaining 56.8% of the variation.
Conclusions To improve nursing students’ clinical competency, developing a more oriented to digital literacy skills and communication competency nursing education program is needed.
The Effect of Teacher-Student Relationship on School Adjustment mediated by Resilience as Recognized by Elementary School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park heejin , Kim Jeongmi
Published: March 2024

Objectives The purpose of this study is to find a direction for successful school adjustment through analyzing the ship between teacher-student relationship, resilience and school adjustment.
Methods The study was conducted on 215 elementary school students from August 21 to 25, 2023. And The data were analyzed using the SPSS 19.0 program. To this end, first, examine the relationship among teacher-student relationship, resilience and school adjustment recognized by elementary school students. And second, analyze the mediating effect of resilience in relation to teacher-student Relationship and school adjustment.
Results First, the correlation between teacher-student relationship, resilience and school adjustment showed significant positive correlation. Second, as a result of analyzing the mediating effect of resilience on the relationship between teacher-student relationship and school adjustment, it was partially mediated.
Conclusions In conclusion, it was confirmed that teacher-student relationship through resilience is important for improving school adjustment.
Effect of Social Activity Participation on Perceived Life Satisfactions of People with Mental Illness through Interpersonal Ability
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Jin Hyang
Published: March 2024

Objectives The purposes of this study were to verify the impact of social activity participation of people with mental illness on perceived life satisfaction and the mediating effect of interpersonal ability.
Methods Data from the 6th year of the 2nd wave of the Employment Panel for the Disabled in 2021 was used, and the subjects were 138 people with mental illness. Descriptive statistics and correlation analysis were performed using the SPSS 25.0 program to check the subjects' general characteristics, normality distribution, and multicollinearity. And the PROCESS Macro model 4 was used to analyze the mediating effects.
Results First, social activity participation by people with mental illness was found to have a direct positive effect on their perceived life satisfaction. Second, it was verified that the interpersonal ability of people with mental illness have a partial mediating effect in the relationship between social activity participation and perceived daily life satisfaction.
Conclusions Based on this result, social welfare implications and suggestions were presented to increase the social activity participation and improve the interpersonal ability.
Development of Instructional Design Model for Peace Education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Jisu , Kim KyungYee
Published: March 2024

Objectives The purpose of this study is to develop a peace education model that can be flexibly applied to diverse learners and diverse educational contexts.
Methods Components of the peace education model were derived through a literature review. Based on this, a model was designed, and the designed model went through a validity verification process through formative research methods. For internal validation, I consulted with four experts who majored in education, and for external validation, I evaluated the usability of seven peace education practitioners and looked at learner responses in the educational field. Through this process, the model was modified and supplemented.
Results The final model, which went through internal and external validation processes, was found to be valid. The peace education class design model developed in this study aims to 'cultivate peace sensitivity' and 'practice in life', starting with 'forming peace relationships', 'safe space', 'attitude open to various perspectives', ‘Ability to start anew’ is a content element. And the operating methods are education about peace (understanding), education for peace (application), and education by peace (acquisition).
Conclusions This study presents a peace education class design model that can be used and applied in peace education fields. The peace education class design model developed in this study has a limitation in that the scope and level of use may vary depending on the instructor's understanding and experience of peace education and the educational environment.
Exploring dyslexia through fundamental cognitive mechanisms
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kwon Sun Young , Song Kwang Han
Published: March 2024

Objectives The purpose of this paper is to identify dyslexia among various types of learning disabilities, explain its manifestation mechanism, and demonstrate it clinically.
Methods This paper shows that through the fundamental cognitive mechanism, not only can the characteristics of dyslexia be understood in the most fundamental, essential, and holistic way, but also a better understanding of how dyslexia is fundamentally manifested. For clinical proof, non-verbal intelligence test (K-CTONI-2), Korean version of Children's Visual Perception Development Test (K-DTVP-3), the Korean Reading Test (KOLRA), and speech hearing test were administered to 7 elementary school students who continued to experience difficulties despite receiving reading education.
Results Dyslexia begins with an excessively imbalanced structure of the brain's large visual and small auditory cognitive spaces. Due to the imbalance between the two cognitive spaces, visual acuity and visual memory appear strong, while auditory acuity and auditory memory appear weak, resulting in auditory internal attention deficit, which is the most important cognitive condition for language development. Auditory internal attention deficit in turn interferes with auditory information processing, resulting in serious difficulties in written language development and various symptoms observed in dyslexic children. The test results showed a low auditory function score compared to a high visual function score.
Conclusions Dyslexia occurs due to functional defects in hierarchical cognitive processes such as auditory sensation, memory, and thought processing caused by an imbalance between the brain's small auditory cognitive space and large visual cognitive space. This paper presents directions for effective dyslexia treatment based on research results.
A Consensual Qualitative Study on the Impact of Game-Based Learning on Faith Maturity
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Sin Woo , Choi Bong Doh
Published: March 2024

Objectives The purpose of this study is to explore and analyze the factors determining the impact of game-based learning on the spiritual maturity of Christian university students.
Methods To achieve this, Christian university students in Daegu Metropolitan City were selected. From December 2022 to February 2023, a Minecraft-based educational program on the life of Jesus was conducted, followed by interviews. The collected data were analyzed using the Consensual Qualitative Research (CQR) method.
Results The analysis yielded three domains, 14 categories, and 35 core concepts. The main findings are as follows. Firstly, game-based learning impacted the cognitive aspects of faith maturity, including understanding of Jesus's life and ministry, geographical, historical, and sociocultural knowledge of the time of Jesus, and integrated comprehension of the Bible. Secondly, game-based learning influenced the emotional aspects of faith maturity, including feelings of gratitude towards Jesus, remorse, love, reflection on faith, and shame. Thirdly, game-based learning was found to be effective in the volitional aspects of faith maturity, such as following the life and teachings of Jesus, examining and improving one's faith life, reading the Bible, loving one's neighbor, and exploring places of faith.
Conclusions This study confirmed that game-based learning, still in its initial stages in the field of Christian education, can become an asset to Christian education by exploring the impact it has on learners' spiritual maturity through university students who have experienced game-based learning. It is also expected to serve as basic material for expanding and developing the realm of Christian education research. Finally, the study offers suggestions and directions for follow-up research.
Exploring the after-school curriculum operation of afternoon reorganization through reflective journal of novice teachers of private kindergarten
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Sin Yoo-jung
Published: March 2024

Objectives In this research, we would like to examine the phenomena related to the operation of the afternoon reorganization after-school course through the reflective journal of novice teachers in private kindergartens. Through this, we intend to seek measures to develop the professionalism of novice teachers who operate after- school courses and alternatives to strengthen support for the field operation of after-school courses.
Methods Participants in the study are Teacher J, who works as an after-school teacher at a private kindergarten, and voluntarily wrote a reflective journal to overcome the difficulties in operating after-school courses. A total of 54 reflective diaries were prepared for 16 weeks from May 16 to August 26, 2022, and qualitative analysis was performed by adding data collected through wired calls and interviews with researchers.
Results The afternoon reorganization after-school course, which appeared in the reflective journal of a novice teachers in a private kindergarten, was analyzed into subcategories of providing sensitive care, attempting various behavioral guidance strategies, and play in which infants participate as the lead. For a novice teachers at a private kindergarten who runs an afternoon reorganization after-school course, the meaning of writing a reflective journal is that I have the opportunity to look at myself, imagine the future, and enjoy reflection.
Conclusions In order to improve the quality of after-school courses, it is necessary to understand the actual condition of various operations of after-school courses, and the process of reflective reflection should be encouraged to enhance the professionalism of novice teachers.
Hybrid Lecture Design Strategy For Student-Centered Education (Student Agency): Focusing on cases of subjects at Incheon National University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Young-Eun
Published: March 2024

Objectives The purpose of this study is to examine a hybrid lecture design strategy that selects and combines various teaching methods to enable learner or student-centered education among the various methods being applied to university classes as part of innovative teaching methods.
Methods This case study analyzes the ‘hybrid innovative lecture design strategy of teaching method’ using the E (Empathy) - D (Design) - I (Implement), 3-Tier stage model and seeks to discover the teaching capabilities required for it. For this purpose, a hybrid lecture design was designed by this researcher, and the subjects of the Division of International Trade in the College of Commerce & Public Affairs at Incheon National University, ‘International Marketing (opened in the second semester of 2022, English course, 57 students in total)’ and ‘Global Korean Wave and Business Strategy for Entertainment’ (Opened in the first semester of 2023, 66 students in total)” was examined. Both subjects were designed to cover learners’ diverse learning backgrounds (nationality, age, grade, gender, major, basic learning orientation and background level, and learning behavior). As a result of the hybrid lecture, learners' class satisfaction scores were 4.853/5 and 5/5, respectively, and both subjects were selected as excellent lectures in the major subjects at Incheon National University.
Results As a result of the research analysis, it can be seen that a strategy of combining various teaching methods ranging from PBL (Problem/Project-Based Learning), MBL (Media-Based Learning), Flipped Learning, Teamwork, Action Learning, Design Thinking, Capstone Design, leadership, communication, career planning feedback, and career development guidance was used depending on the learning progress. Through it, this study examines how a diverse range of teaching competencies and students’ essential core competencies could be matched with teaching methods.
Conclusions This case study examines a hybrid lecture design that combines various teaching methods to achieve learner-centered education (student agency) and the resulting teaching capabilities. Hybrid strategies for lecture design play a pivotal role in reflecting the needs of learners and the changed educational environment in changing learner attitudes from passive and mechanical to active, creative, proactive, and constructive ones.
Implikasi Metode Tarjih dalam Menyikapi Hadis-Hadis Kontradiktif
Authors: Mannan Nuraini A
Published: March 2024

In the course of their development, scholars frequently encounter Hadiths of Prophet Muhammad SAW that appear contradictory or exhibit differences in opinion (ikhtilaf), complicating their utilization as arguments or evidence. To address this challenge, scholars have devised various methodologies, with tarjih emerging as the principal solution for resolving these discrepancies. This research aims to answer two main questions: 1) What are the principles involved in the tarjih process of Hadiths? and 2) How is the tarjih method applied to Hadiths deemed contradictory? Utilizing a literature review approach, this study collects and analyzes relevant data. It identifies seven primary principles in the tarjih of contradictory Hadiths, encompassing the investigation of narrators' conditions, the age of narration, the methodology of narration, the timing of narration, the phrasing of the Hadith, the legal content, and external factors. These findings offer new perspectives in Hadith studies, particularly in addressing disagreements related to Hadiths.

ABSTRAK

Dalam pengembangannya, para ulama sering kali menemukan hadis-hadis Nabi Muhammad SAW yang tampak kontradiktif atau mengalami perbedaan pendapat (ikhtilaf), yang menyulitkan penggunaannya sebagai argumen atau hujjah. Untuk mengatasi permasalahan ini, ulama telah merumuskan berbagai metode, dengan tarjih menjadi solusi utama dalam menyelesaikan ikhtilaf tersebut. Penelitian ini bertujuan untuk menjawab dua pertanyaan utama: 1) apa saja prinsip-prinsip dalam proses tarjih hadis, dan 2) bagaimana penerapan metode tarjih pada hadis-hadis yang dianggap kontradiktif. Melalui metode kepustakaan, penelitian ini mengumpulkan dan menganalisis data terkait. Hasilnya, ditemukan tujuh prinsip utama dalam tarjih hadis yang kontradiktif, meliputi penelusuran keadaan perawi, usia periwayatan, metode periwayatan, waktu periwayatan, redaksi hadis, kandungan hukum, dan faktor eksternal. Temuan ini memberikan wawasan baru dalam studi hadis, khususnya dalam menyelesaikan perbedaan pendapat terkait hadis.
PENGEMBANGAN MEDIA CAREER FLASHCARD TERHADAP PERENCANAAN KARIER SISWA DI SMPN 3 NGAMPRAH
Authors: Nugraha  , Hendriana Heris , Masyita Suherman Maya
Published: March 2024

Inaccuracies in the career planning of students can cause failure in the future, if the work they get is considered not in accordance with their type or personal style, it will cause discomfort at work, and in the end it will end up being an increase in unemployment in Indonesia. Therefore the need for career planning that is done early on. One of the media that can be used in planning a student's career at school is a media career flashcard which is packaged in the form of a fun game. This study was conducted to determine the feasibility of career flashcard media in career guidance services. This research is a development research (RnD) which was carried out with several validation tests, namely by conducting validation tests on experts and limited trials to 10 students and broad testing to 40 students of class VIII-I at SMPN 3 Ngamprah. The assessment of the suitability of the career flashcard media was carried out by the validator and carried out a limited and extensive test with the final result of the career flashcard product validity test being 94.46% which was included in the "very suitable for use" category after revising. From the development of the career flashcard media product that was made in carrying out career planning for class VIII students at SMPN 3 Ngamprah. With career guidance services using career flashcard media, it was found that students opened their horizons in planning future careers that were tailored to their personality type.
PENGARUH LAYANAN BIMBINGAN KARIER TERHADAP MINAT KARIER SISWA KELAS XI SMA MUTIARA 2 BANDUNG
Authors: Rayni Selma , Siddik Riesa Rismawati , Rohaeti Euis Eti
Published: March 2024

This study aims to determine the effect of career guidance services on career interests of class XI students SMA Mutiara 2 Bandung. This research uses the research method of counseling guidance action (PTBK) with the subject of research as many as  20 students of clas XI SMA Mutiara 2 Bandung. The method of data collaction using observation, interviews, and research documentation. Consists of 2 cycles. While the data analysis technique used descriptive analytical analysis. The process of data analysis begins by examining all the data obtained, either though interviews or observations. Then described by using percentage analysis. The Results of the study indicate that in the initial conditions,students’ career intrests are still in the “not good” category, in the first cycle there are indicators that have increased in the “very good” category, namely the indicator of introduction to the world of work with descriptors knowing the world of work, with percentage of by 75% of the 15 students. While in the second cycle all indicators have increases by getting the “very good” category with a percentage of >80% on each indicator from 18 students. Thus, it can be concluded that career guidance services can affect the career interests of students in class XI SMA Muttiara 2 Bandung.
PENGEMBANGAN MODUL UNTUK MENINGKATKAN SELF EFFICACY SISWA KELAS VII SMPN 5 CIMAHI
Authors: Reswari Yassinta Alhumaira , Rohaeti Euis Eti , Septian Muhammad Rezza
Published: March 2024

This article aims to determine the feasibility and effectiveness of the module to This article aims to develop a module to improve the self-efficacy of class VII students of SMPN 5 Cimahi. The subjects in this study were 26 students of class VII and 3 validators to test the feasibility of the module. This study uses the R&D (Research and Development) method by going through 9 stages. The data analysis used is a feasibility test to determine the feasibility of the module that will be used to improve student self-efficacy and the t-test test used to determine the effectiveness of the module to increase self-efficacy. Based on the results of the feasibility test, it was stated that the module was in the "very feasible" category to be used as a medium for implementing guidance and counseling services with a score of 94.6% from material experts, 96.6% from media experts, and 82.3% from practitioners ( guidance and counseling teacher). In addition, the results of the feasibility test limited to students also obtained a score of 79.4% and the broad feasibility test with a score of 87%. Based on these results, the module can be used as a medium for implementing guidance and counseling services in schools. Looking at the results of the module effectiveness test to increase self-efficacy, it also has a significant result of 0.00 <0.05, which means that through the media module, the self-efficacy of class VII students can increase.
EFEKTIVITAS MODUL BIMBINGAN DAN KONSELING BERBASIS HANDBOOK TERHADAP PROKRASTINASI AKADEMIK SISWA KELAS XI SMAN 1 SAGULING
Authors: Fauzi Syahrul Ahmad , Hendriana Heris , Rezza Septian Muhammad
Published: March 2024

Procrastination is often experienced by teenagers. Procrastination in adolescents is caused by several factors such as wasting time, avoiding tasks, and blaming others. This study aims to determine the effectiveness of the module on academic procrastination of class XI students of SMAN 1 Saguling. The subjects in this study were 30 students of class XI and were selected based on the recommendation of the guidance and counseling teacher on the consideration of the highest level of students experiencing procrastination. Data analysis used normality test and t test. The trial process for the handbook based guidance and counseling module was carried out by distributing pretest and posttest questionnaires, calculating the effectiveness using SPSS and carried out 2 times, namely normality test and T-test on pretest and protest during the trial. The results of the normality test showed the significance value of the pretest was 0.111 and the posttest was 0.008 so that the normality test can be said to be normally distributed. The results of the t-test showed a 2-tailed significance value of 0.000 so that in this t-test there was a difference between the pretest and posttest variables because they had a 2-tailed significance value 0.05. So that the results of the t-test carried out can be seen that the developed module is proven to be effective on academic procrastination of class XI students of SMAN 1 Saguling.
HEAT TRANSFER COEFFICIENT SIMULATION AND TEMPERATURE DISTRIBUTION PREDICTION OF WIRE LOOPS IN THE STELMOR AIR-COOLING SYSTEM
Authors: Zhao Qianlong , Su Fu-yong , Li Bin , Li Cunwang , Fan Guangyan
Published: March 2024

During the Stelmor air-cooling process, the temperature distribution has
a significant impact on the wire loops’ final mechanical properties. The
temperature distribution during air-cooling process is accurately solved
by establishing three-dimensional model and numerical simulation. The
heat transfer coefficient at the high dense region is much smaller than
that of wire loops at the low dense region, and changes periodically
over time, according to a Computational Fluid Dynamics (CFD) simulation
method. It is also found that the heat transfer coefficient on the cross
section of the wire loop is very different, with a difference of 70-100
Wm-2K-1. Finally, the finite difference method is used to calculate the
mathematical model of the temperature distribution during the Stelmor
air-cooling process. Comparing the results with the measurement data,
the simulation results and measurement data match up well.
Long term ventilation into pediatric central apneas: etiologies, profiles and therapeutic approaches over a decade
Authors: Presti Santiago , Pavone Martino , Verrillo Elisabetta , Paglietti Maria Giovanna , Colle Anna Del , Leonardi Salvatore , Cutrera Renato
Published: March 2024

Central apneas are a prevalent yet complex phenomenon, particularly
among children. This retrospective study, conducted over a decade (from
2012 to 2022), analyzed central apneas in a cohort of 612 pediatric
patients who underwent ventilation at the Sleep Medicine and Long-Term
Ventilation Unit of the Bambino Gesù Children’s Hospital in Rome, Italy.
Among this group, 67 patients met the inclusion criteria for central
apneas. Central apneas often arise within the context of various
underlying pathologies, including neurological disorders, genetic
syndromes, and brain tumors. We categorized patients into three main
groups including patients with “exclusively central apneas”,
“predominantly central apneas”, and “predominantly obstructive
apneas”. Ventilation modes were diverse, with pressure-controlled
ventilation and pressure support being commonly used, reflecting the
individualized nature of therapy. The choice of ventilation mode has
been influenced by the underlying diagnosis and the severity of central
apneas, with pressure support ventilation being the most frequently
employed mode. Continuous Positive Airway Pressure was also employed in
select cases. A statistically significant reduction (p<0.05)
in mean cAHI was observed in patients with multimalformation syndromes,
hypoxic-ischemic encephalopathy and Prader-Willi Syndrome. The reduction
in mean cAHI was not statistically significant in the case of patients
with brain tumors. While non-invasive ventilation was commonly used,
invasive mechanical ventilation was selectively employed in more severe
cases. The study highlights the need for personalized therapeutic
strategies when managing central apneas in pediatric patients.
Observer Based Robust-Adaptive Fractional-Order Control for Cable Parallel Robots in the Presence of Perturbations and Model Uncertainties Characterized by Unknown Nonlinear Functional Upper Bounds
Authors: Peimani Mansour , Jafarlou Farzad , Lotfivand Nasser
Published: March 2024

This article investigates the challenges of stabilizing Cable Suspended
Parallel Robots (CSPRs) when dealing with uncertainties in models and
external disturbances. It presents a novel Robust Adaptive
Fractional-Order Sliding Mode Controller (RAFOSMC) designed specifically
to handle uncertain nonlinear functional upper bounds that define
disturbances and uncertainties. The approach employs stable adaptive
laws to determine the unknown coefficients within the perturbation
functional upper bounds. Analysis demonstrates that the Fractional-Order
Sliding Mode Controller (FOSMC) surpasses traditional Integer-Order
Sliding Mode Controllers (IOSMC). FOSMC exhibits advantages such as
decreased chattering, swifter convergence toward the intended trajectory
during initial movement, and eventual finite-time convergence to the
fractional sliding surface. The study also proposes an innovative
approximation for the sign function to further minimize chattering.
Additionally, for situations where cable states are unavailable, the
study introduces a nonlinear observer capable of estimating both cable
position and model perturbations. Simulation results and comparisons
with recent research support the efficacy of the proposed approaches.
Accuracy assessment and uncertainty of 10-m resolution land use land cover maps at the local scale. Case: Talassemtane National Park, Morocco
Authors: Chemchaoui Abdelaziz , Alaoui Hassana Ismaili , Ghazi Souad , Boukita Hassan , Brhadda Najiba , Ziri Rabea
Published: March 2024

Global land use land cover (LULC) maps are essential for monitoring
forest dynamics and are a useful tool for any spatial planner. An
increasing number of institutes are interested in producing such maps,
especially with freely available high-resolution imagery and the
emergence of new classification techniques. However, these maps should
be submitted to an accuracy assessment for more accurate and effective
use at the regional, national, and local scales. In this study, two
products, the European Space Agency World Cover 2020 (ESA WC2020) and
Sentinel-2 10 m Land Use/Land Cover Time Series (ESRI LC2020), were
subjected to an accuracy assessment at the local scale, particularly in
Talassemtane National Park (TNP). The results showed an overall accuracy
of 56.90 % for the ESA product and 83.56% for the ESRI product. Forest
cover is the most accurate land cover class for both products. In
addition, area-based accuracy was used to adjust each class’s area and
evaluate uncertainty. Finally, spatial agreement between the two
products was achieved using change detection analysis, which showed a
result of 70% at the local level. This work will be used in studies in
the TNP area to distinguish between forest and non-forest land,
particularly to monitor deforestation.
Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR Signaling Pathways
Authors: Zamanian Mohammad Yassin , Golmohammadi Maryam , Yumashev Alexey , Hjazi Ahmed , Toama Mariam Alaa , AbdRabou Mervat Ahmed , Gehlot Anita , Alwaily Enas R. , Shirsalimi Niyousha , Yadav Pankaj Kumar , Moriasi Gervason
Published: March 2024

Metformin (MET) is a preferred drug for the treatment of type 2 diabetes
mellitus. Recent studies show that apart from its blood glucose-lowering
effects, it also inhibits the development of various tumours, by
inducing autophagy. Further, various studies have confirmed the
inhibitory effects of MET on cancer cell lines’ propagation, migration,
and invasion. However, despite the many publications on the anticancer
potential of MET, there is no existing comprehensive review and account
of its autophagy-associated anticancer activity, this review. This
review noted that MET exerts its anticancer effects by regulating key
signalling pathways such as phosphoinositide 3-kinase (PI3K), LC3-I and
LC3-II, Beclin-1, p53, and the autophagy-related gene (ATG), inhibiting
the mTOR protein, downregulating the expression of p62/SQSTM1, and
blockage of the cell cycle at the G0/G1. Moreover, MET can stimulate
autophagy through pathways associated with the 5′ adenosine
monophosphate-activated protein kinase (AMPK), thereby inhibiting he
development and progression of various human cancers, including
hepatocellular carcinoma, prostate cancer, pancreatic cancer,
osteosarcoma, myeloma, and non-small cell lung cancer. Therefore, this
detailed review provides a framework for further investigations that may
appraise the autophagy-induced anticancer potential of MET and its
repurposing for cancer treatment.
Prescribing Patterns of SGLT2 inhibitors and GLP-1 receptor agonists in Patients with T2DM and ASCVD in South Korea
Authors: Je Nam Kyung , Eom Yeong Rok , Joo Hajung , Chae Seung Eun
Published: March 2024

Background: Despite cardiovascular benefits of sodium-glucose
cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor
agonists (GLP1RA) in patients with type 2 diabetes mellitus (T2DM) and
atherosclerotic cardiovascular disease (ASCVD), their utilization
remains low globally. This study aimed to evaluate the utilization of
SGLT2i and GLP1RA in patients with T2DM and ASCVD, as well as the
factors associated with medications in South Korea. Methods:
This retrospective study was conducted from 2015 to 2020, using National
Patient Sample claims data. The study population included adult patients
with confirmed T2DM and ASCVD diagnosed between March 1 and October 31
each year. Demographic and clinical characteristics, and influencing
factors were investigated. Results: Among 57,576 study
participants, SGLT2i use increased from 1.2 % to 10.51 % during the
study period, whereas GLP1RA use increased slightly from 0 % to 1.17
%. Older age, comorbid chronic kidney disease, concurrent use of
dipeptidyl peptidase 4 inhibitors (DPP4i), and prescriptions from
specific physician specialties negatively influenced SGLT2i use.
Conversely, comorbid dyslipidemia, heart failure, concurrent use of
sulfonylurea (SU), and prescriptions from cardiologists positively
influenced SGLT2i use. For GLP1RA, older age, concurrent DPP4i use, and
specific physician specialty were negative factors, whereas female sex,
dyslipidemia, insulin, and SU use were positive factors.
Conclusions: Despite increasing utilization, 88.35 % of
eligible patients remained untreated with SGLT2i and GLP1RA as of 2020.
This study highlights the disparities in utilization based on patient
characteristics and physician specialties, emphasizing the need to
remove barriers and enhance clinical benefits for high-risk patients.
Habitat Opening Fostered Diversity: Impact of Dispersal and Habitat-shifts in the Diversification of a Speciose Afrotropical Insect Group
Authors: Hévin Noémie , Goldstein Paul , Aduse-Poku Kwaku , Barbut Jérôme , Mitchell Andrew , Zilli Alberto , Clamens Anne-Laure , Capdevielle-Dulac Claire , Wahlberg Niklas , Ru Bruno Le , Kergoat Gael
Published: March 2024

The opening of habitats associated with the emergence of C4 grasslands
during the Neogene has had a massive influence on the evolution of plant
and animal communities. Strikingly, the impacts of grassland expansion
on species diversification in Africa, where the largest surface of
grasslands and savannas in the world is located, are not well
understood. To explore the impact of habitat opening, we investigate the
evolution of noctuid stemborers, a group of moths mostly associated with
open habitats, and whose diversity is centered in the Afrotropics. We
generate a dated molecular phylogeny for ca. 80% of the known stemborer
species and assess the role of habitat opening on the evolutionary
trajectory of the group through a combination of parametric historical
biogeography, ancestral character state estimation, life history traits
and habitat-dependent diversification analyses. Our results support an
origin of stemborers in Southern and East Africa ca. 20 million years
ago (Ma), with range expansions linked to the increased availability of
open habitats to act as dispersal corridors, and closed habitats acting
as potent barriers to dispersal. Early specialization on open habitats
was maintained over time, with shifts towards closed habitats being rare
and invariably unidirectional. Analyses of life history traits showed
that habitat changes involved specific features likely associated with
grassland adaptations, such as variations in larval behavior and color.
We compare these findings to those previously inferred for an
Afrotropical butterfly group that diversified roughly in parallel with
the stemborers but distributed predominantly in closed habitats.
Remarkably, these two groups show nearly opposite responses in relation
to habitat specialization, whether in terms of biogeographical patterns,
or in terms of rates of transition between open and closed habitats. We
conclude that habitat opening played a major role in the diversification
of Afrotropical lineages through dispersal and adaptation linked to
habitat shifts.
Research on the Fusion of Time-Series Sentinel-1 Data and Phenological Features for Sugarcane Planting Distribution Extraction
Authors: Chen Senzheng , Ye Huichun , Huang Shanyu , Zhao Longlong , Nie Chaojia , Hu Weixia
Published: March 2024

The extraction of sugarcane planting distribution provides a scientific
basis and theoretical support for local sugarcane cultivation management
and the prediction of sugarcane yield. Sugarcane predominantly grows in
tropical and subtropical regions characterized by cloudy and rainy
conditions. Optical satellite remote sensing imagery is greatly affected
by cloud and rain interference. In contrast, synthetic aperture radar
(SAR) data exhibit strong penetration capabilities, enabling effective
imaging in overcast, rainy, and cloudy environments. Focusing on Fusui
County, Guangxi Province, China, this research utilizes Sentinel-1 radar
data and integrates the phenological features of sugarcane growth. A
sugarcane planting distribution extraction model is constructed using a
random forest classifier. The results demonstrate that the phenological
feature approach based on temporal radar scattering characteristics
achieves superior performance in sugarcane identification and
extraction. The overall accuracy surpasses 92.18%, with a Kappa
coefficient of 0.89. This method exhibits a 4.95% accuracy improvement
compared to single-period radar scattering feature methods. Therefore,
this radar-based method for extracting sugarcane planting distribution
can effectively and accurately extract sugarcane cultivation patterns in
regions with complex cloud and rain conditions, such as Guangxi
Province. It also serves as a methodological reference for extracting
crop planting distributions in cloudy and rainy areas.
GENOTYPE-BY-GENOTYPE INTERKINGDOM CROSS-TALK BETWEEN SYMBIOTIC NITROGEN FIXING SINORHIZOBIUM MELILOTI STRAINS AND TRICHODERMA SPECIES
Authors: Vaccaro Francesca , Passeri Iacopo , Ajijah Nur , Bettini Priscilla , Courty Pierre-Emmanuel , Dębiec-Andrzejewska Klaudia , Joshi Namrata , Kowalewska Łucja , Stasiuk Robert , Musiałowski Marcin , Pranaw Kumar , Mengoni Alessio
Published: March 2024

In the understanding of the molecular interaction between plants and
their microbiome, a key point is to identify simplified models of the
microbiome including relevant bacterial and fungal partners which could
also be effective in plant growth promotion. Here, as proof-of-concept,
we aim to identify the possible interactions between symbiotic
nitrogen-fixing rhizobia and soil fungi (Trichoderma spp.), hence shed
light on synergistic roles rhizospheric fungi could have in the
symbiotic nitrogen fixation with host plants. We selected 4 strains of
the model rhizobium Sinorhizobium meliloti and 4 Trichoderma species (T.
velutinum, T. tomentosum, T. gamsii and T. harzianum). In an
experimental scheme of 4 x 4 strains x species combinations, we
investigated the rhizobia physiological and transcriptomic responses
elicited by fungal spent media, as well as spent media effects on
rhizobia-host legume plant (alfalfa, Medicago sativa L.) symbiosis.
Fungal spent media had large effects on rhizobia, specific for each
fungal species and rhizobial strains combination, indicating a general
rhizobia genotype x fungal genotype interaction. Differential expression
of a high number of genes was shown in rhizobia strains. Moreover,
changes in rhizobia exopolysaccharide and auxin production were
identified in response to fungal spent media. Different rhizobium-fungus
combinations were also shown to have synergistic effects on alfalfa
symbiotic phenotypes. Our results provide a first insight into
interactions involving nitrogen-fixing rhizobia and rhizospheric fungi,
highlighting the panoply of genes and genotypic interactions (fungus,
rhizobium, host plant) which may concur to plant symbiosis.
The role of child gender and age in teacher-child relationship, self-regulation, social emotions and academic achievement in preschool: A multi-group structural equation modeling approach
Authors: Bai Barry , Li Jing , Yu Yongjia
Published: March 2024

This study explored the relationships among teacher-child relationship
(TCR), self-regulation (SR), social emotions (SE), and children’s
learning of mathematics and vocabulary while considering the influence
of gender and age. Two hundred seventy children (boys = 154, girls =
116) aged 3-6 years (Mage = 59.44 months) participated across 18 classes
in three preschools. The results from multi-group structural equation
modeling (SEM) revealed significant gender differences of TCR when
predicting SR and SE. However, no significant gender differences were
observed when SR predicted mathematics and vocabulary, or SE predicted
these two. SR emerged as the most potent predictor of mathematics for
all children. Furthermore, significant age variations were identified in
TCR when predicting SR and SE and when SR and SE predicted mathematics
and vocabulary. Finally, the research discusses implications for
teachers, emphasizing the importance of tailored support for children of
different genders and age groups to enhance TCR, SR, and SE.
Cross-reactive antibody responses to coronaviruses elicited by SARS-CoV-2 infection or vaccination
Authors: Lee Richard SH , Cheng Samuel , Zhao Jin , Tsoi Annie YS , Lau Kaman KM , Chan Coco HC , Li John KC , Hui David , Peiris Malik , Yen Hui-Ling
Published: March 2024

Background The newly emerged SARS-CoV-2 possesses shared antigenic
epitopes with other human coronaviruses. We investigated if COVID-19
vaccination or SARS-CoV-2 infection may boost cross-reactive antibodies
to other human coronaviruses. Methods Pre- and post-vaccination sera
from SARS-CoV-2 naïve healthy subjects who received three doses of the
mRNA vaccine (BioNTech, BNT) or the inactivated vaccine (CoronaVac, CV)
were used to monitor the level of cross-reactive antibodies raised
against other human coronaviruses by enzyme-linked immunosorbent assay.
In comparison, convalescent sera from COVID-19 patients with or without
prior vaccination history were also tested. Pseudoparticle
neutralization assay was performed to detect neutralization antibody
against MERS-CoV. Results Among SARS-CoV-2 infection naïve subjects, BNT
or CV significantly increased the anti-S2 antibodies against
Betacoronaviruses (OC43 and MERS-CoV) but not Alphacoronaviruses (229E).
The pre-vaccination antibody response to the common cold human
coronaviruses did not negatively impact the post-vaccination antibody
response to SARS-CoV-2. Cross-reactive antibodies that binds to the S2
protein of MERS-CoV were similarly detected from the convalescent sera
of COVID-19 patients with or without vaccination history. However, these
anti-S2 antibodies do not possess neutralizing activity in MERS-CoV
pseudoparticle neutralisation tests. Conclusions Our results suggest
that SARS-CoV-2 infection or vaccination may potentially modulate
population immune landscape against previously exposed or novel human
coronaviruses. The findings have implications for future
sero-epidemiological studies on MERS-CoV.