bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of life of women with endometriosis: a systematic review
Authors: AlHarbi Manal , Almubarak Raghad , AlOmar Safana , Almazrou Norah , Fatani Bader , Almubarak Danah
Published: January 2025

Endometriosis is a chronic neuro-inflammatory disorder that is associated with debilitating chronic pelvic pain. Pain symptoms associated with endometriosis, including chronic pelvic pain, can negatively affect women. There is a negative influence of endometriosis on the general health of women, and pain associated with endometriosis is the main responsible cause for the negative effect of the disease on the quality of life. Hence, this systemic review was conducted to identify the quality of life among women with endometriosis by reviewing the previous studies conducted on this subject. The databases of PubMed, Scopus, Elsevier, and Google Scholar were explored starting from 2019 till 2023 to obtain articles related to the study subject. The included search keywords were "Impact, effect, influence, association, correlation, QOL, endometriosis". The inclusion criteria were original articles conducted on women with endometriosis and reported QOL among them. A total of 898 articles were obtained, and only eight articles were eligible for the inclusion criteria. The studies included a total number of 1665 women. The tools used for QOL assessment included EHP-30, EHP-5, SF-36, SF-12, and WHOQOL-BREF. The QOL among women with endometriosis is low and significantly deteriorates due to the delay in diagnosis. Also, there are various factors associated with QOL impairment. However, improving QOL can be achieved by early diagnosis and treatment.
Assessment of health consequences of sleep deprivation among Fakeeh College students during the exams
Authors: Fahim Ahmed , Hasanain Hashem , Mahmoud Albalawii , Fawzi Alghamdi , Beerkdar Mustafa , Alotaibi Raad , Khawajah Mohammed
Published: January 2025

Objective:
This study aimed to investigate the association between sleep quality, academic stress, and health perceptions among medical students at Fakeeh College in Saudi Arabia.
Methods:
This four-month cross-sectional study included 408 undergraduate medical students from various specialties at Fakeeh College. Participants completed an electronic self-administered questionnaire that comprised demographic information, academic performance indicators, health perception questions, and the Pittsburgh Sleep Quality Index (PSQI).
Results:
The majority of participants (88.0%) were aged 18-22 years, with a near-equal gender distribution (51.0% male, 49.0% female). The overall mean PSQI score was 7.26, indicating moderate sleep disturbances among students. Older students (23-28 years) and females reported significantly higher PSQI scores, suggesting poorer sleep quality. Nursing and Pharmacy students also exhibited higher PSQI scores compared to MBBS students. Health perception was strongly correlated with sleep quality; students with better health ratings reported lower PSQI scores. Exam-related stress significantly impacted sleep quality, with students experiencing higher levels of pain, anxiety, and reduced social activities reporting poorer sleep quality.
Conclusion:
This study highlighted the significant impact of demographic factors, health perceptions, and academic stress on sleep quality among medical students. The findings suggested a need for targeted interventions to improve sleep hygiene and support mental health, particularly for older students, females, and those in demanding academic programs. Addressing these issues could enhance both academic performance and overall well-being.
Epidemiological patterns of skin cancer in Saudi Arabia: a systematic review and meta-analysis of patient demographics, cancer types, locations, and risk factors
Authors: Alshehri Hamza , Alasiri Raghad , Alahmari Maryam , Daghriri Lujain , Badawi Fatimah , Sultan Ibtihal , Hamdan Jood , Alzahrani Alaa , Alghamdi Rahf , Alzufairi Ahmad
Published: January 2025

Skin cancer, which includes both melanoma skin cancers (MSCs) and non-melanoma skin cancers (NMSCs), is a major health problem around the world. Although NMSCs, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most prevalent, melanoma remains the most lethal. This systematic review and meta-analysis, following PRISMA guidelines, evaluated the epidemiology of skin cancer in Saudi Arabia, emphasizing patient demographics, cancer types, anatomical locations, and risk factors. A comprehensive literature search across PubMed, Scopus, and Web of Science yielded 11 studies meeting the inclusion criteria. These retrospective studies spanned diverse Saudi regions, with publication years ranging from 1993 to 2023 and sample sizes from 27 to 557 participants. Male predominance was evident, with males comprising up to 74.5% of participants in some studies. The prevalence of BCC ranged from 26% to 68.5%, SCC from 14.7% to 44.8%, and malignant melanoma (MM) from 3.5% to 11.7%. Head and neck regions were the most affected anatomical sites, reported in 46.95%–79.6% of cases. The pooled prevalence of BCC, SCC, and MM was 43%, 27%, and 8%, respectively, with significant heterogeneity among studies (I² > 50%). Male gender and UV exposure emerged as critical risk factors, with additional contributions from immunosuppression and genetic predispositions, such as xeroderma pigmentosum. High-quality studies identified robust epidemiological patterns, while moderate-quality studies highlighted gaps in controlling for confounders. These findings underscore the need for targeted skin cancer prevention and management strategies tailored to Saudi Arabia's demographic and environmental profile. Addressing UV exposure, public awareness, and early detection remain pivotal.
Association of diabetes mellitus type-2 with knee pain severity and pattern in people with knee osteoarthritis and effects on physical activity
Authors: Banjar Asrar , Alsulami Rola , Asiri Jamila , Alharbi Ahmad , Sadakah Ghadir , Almatrafi Faisal , Elrggal Mahmoud , Kalantan Nadeen , Hafiz Waleed
Published: January 2025

Objective:
The current study aimed to assess the effect of diabetes mellitus (DM) on knee pain severity and distribution among patients with osteoarthritis (OA).
Methods:
A descriptive cross-sectional study was conducted targeting all patients with established diagnoses of OA at Alnoor Specialist Hospital in Makkah, Saudi Arabia from November 16, 2022, to March 18, 2023. Data were collected using an Arabic-language questionnaire administered through phone calls with the patients after being informed verbally. A validated Intermittent and Constant Osteoarthritis Pain Questionnaire (ICOPQ), and an International physical activity questionnaire (IPAQ) were used for assessing pain and physical activity. Patients who had undergone knee joint replacement surgery and those who had traumatic deformities were excluded.
Results:
A total of 169 knee osteoarthritis (OA) patients were included in this study. The data illustrated a diverse sample of patients with an average age of 57.1 years (±10.7) and a higher representation of females (69.2%). Rheumatoid arthritis was observed in 4.1% of patients, while hand arthritis, spinal arthritis, feet arthritis, and back pain were each present in 2.4%, 1.2%, 1.2%, and 1.2% of patients, respectively. The total pain scores, with mean ± SD values of 43.6 ± 20.7 for the DM and OA group and 43.1 ± 23.6 for the non-diabetic OA group, did not significantly differ with a p-value of 0.887.
Conclusion:
The prevalence of OA-associated pain was high with higher severity of pain score and limited activity among diabetic patients than non-diabetics.
G6PD Deficiency and Parkinson's Disease: An emerging correlation
Authors: Uppal Komal , Kaushik Himani , Polipalli Sunil , Kumar Somesh , Kapoor Seema
Published: January 2025

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency, recognized as the most prevalent enzymopathy globally, limits pentose phosphate pathway (PPP), causing oxidative damage to dopaminergic nigrostriatal (DNS) neurons, has been implicated as a potential risk factor for early-onset Parkinson's disease (EOPD).
Case presentation: This study details case of 45-year-old male presenting with EOPD. Patient presented with unsteady walk, tremors in left hand and leg, alongside gait disturbances. While biochemical assessments and MRI investigations yielded unremarkable results, Tc-99m TRODAT brain SPECT/CT imaging indicated presynaptic dopaminergic dysfunction within the bilateral basal ganglia. Treatment with Syndopa and Propranolol proved effective.
Conclusion: The combination of genetic, clinical, and imaging findings suggests a potential link between G6PD deficiency and Parkinsonism, supporting the possibility of G6PD playing a role in the development of Parkinson's disease (PD) in this case. This report underscores the necessity for further epidemiological studies to confirm the association between G6PD deficiency and PD in adults. Further research is essential to elucidate the mechanistic pathways connecting G6PD deficiency to dopaminergic dysfunction and to explore its implications for the pathogenesis, early diagnosis, and therapeutic strategies for PD.
La creación actoral de Buenos Aires en perspectiva ideológica
Authors: Rivarola Larisa
Published: January 2025

Artículo que aborda aspectos de una investigación reciente sobre las formas de producción teatral en el Subsistema Alternativo de la ciudad de Buenos Aires durante los años 2003-2015. Se exponen las concepciones artísticas, imaginarios y prácticas evidenciadas en las formas de producción de un corpus de obras teatrales. Se reflexiona sobre la subjetividad de las y los teatristas frente la propia práctica, y para ello se plantean dos categorías de análisis: actuación subordinada y actuación soberana. A partir de ellas y dadas las características políticas de la época, se discute la relación de la práctica escénica con el Estado argentino. Finalmente, se expone el vínculo entre la gestión pública, las demandas de teatristas y el modo en que éstos desarrollaban su actividad.
Theatrical Acting in Buenos Aires from an Ideological PerspectiveAbstractThe article presents aspects of a research project that delves into the forms of theater production in the alternative subsystem of the city of Buenos Aires (2003-2015). The author discusses the artistic conceptions, practices and imaginaries of theatre artists, as evidenced in the forms of production of a given corpus of works. The subjectivity of theater practitioners in relation to their practice is addressed by means of two categories of analysis: subordinate performance and sovereign performance. Given the political climate of the project’s timeframe, the author discusses the relationship of theatrical practice with the Argentinian State. The article concludes presenting the link between public management, the demands of the theater workers and the way in which they carried out their activity during those years.
Recibido: 17 de abril de 2024Aceptado: 10 de julio de 2024
Desencuentros entre los sexos en Resguardo personal, de Paloma Pedrero: una lectura psicoanalítica
Authors: Marín Calderón Norman
Published: January 2025

Resguardo personal (1985) de Paloma Pedrero ilustra magistralmente el aforismo lacaniano “no hay relación sexual” por cuanto entre hombre y mujer existe un desencuentro irremediable entre sus goces (jouissance). Marta y Gonzalo –protagonistas de la obra– encarnan la máxima de que ambos sexos no son complementarios. Afirmar la ausencia de relación sexual no niega el acto genital, sino que más bien alude a la imposibilidad estructural de que entre hombre y mujer se pueda producir un encuentro. El acto de formular la no relación sexual manifiesta la inviabilidad del mito de la “media naranja”, ficción que se puede comprobar como irrealizable entre ambos esposos, pues sus encuentros amorosos son frecuentemente sucedidos por desencuentros inexorables, los cuales principalmente ocurren gracias al poder del lenguaje en la obra.
Misencounters Between the Sexes in Paloma Pedrero’s Resguardo personal: A Psychoanalytic ReadingAbstractResguardo personal (1985) by Paloma Pedrero masterfully illustrates the Lacanian aphorism “there is no sexual relation (rapport)” because between man and woman there is an irremediable disparity between their pleasures/enjoyments (jouissance). Marta and Gonzalo –protagonists of the play– embody the maxim that both sexes are not complementary. To affirm the absence of sexual relation does not deny the genital act, but rather alludes to the structural impossibility of an encounter between man and woman. The act of formulating the non-sexual relation manifests the unfeasibility of the myth of the “soulmate”, a fiction that can be proved to be unrealizable between both spouses since their amorous encounters are usually followed by inexorable disagreements, which mainly occur due to the power of language in the play.
Recibido: 20 de julio de 2023Aceptado: 15 de marzo de 2024
Pengembangan Alat Pengaduk dengan Sistem Pembuangan Uap untuk Usaha Pembersih Lantai di Kota Padang
Authors: Andre Hanalde , Emeraldi Primas , Luthfi Amirul , Ramadhamy Queen Hesti , Tomas Micko , Pratama Rizki Wahyu , Herier Gilang Ramadhan , Putra Rangga , Antoni Jefri
Published: January 2025

Produksi pembersih lantai di Kecamatan Pauh, Kota Padang, menghadapi kendala dalam proses produksi, terutama pada tahap pengadukan bahan kimia yang dilakukan secara manual. Proses ini tidak hanya memakan waktu lama dan tidak efisien, tetapi juga menghasilkan uap berbahaya yang berdampak pada kesehatan pekerja dan masyarakat sekitar. Penelitian ini bertujuan untuk mengembangkan alat pengaduk otomatis yang dilengkapi dengan sistem pembuangan uap guna meningkatkan efisiensi produksi, kualitas produk, dan keselamatan kerja. Alat yang dirancang terdiri dari motor listrik, modul pengatur kecepatan, pewaktu, serta sistem pembuangan uap yang efektif. Metode penelitian mencakup tahapan perancangan, implementasi, dan evaluasi kinerja alat. Evaluasi dilakukan untuk menilai efektivitas alat dalam mempercepat waktu produksi, menjaga standar kualitas produk, dan mengurangi risiko kesehatan. Hasil pengembangan menunjukkan bahwa alat pengaduk otomatis mampu meningkatkan efisiensi produksi, menurunkan biaya operasional, serta meningkatkan keselamatan kerja secara signifikan. Selain itu, penerapan alat ini juga memberikan manfaat berupa standarisasi kualitas produk dan pengurangan dampak negatif terhadap lingkungan. Hasil penelitian ini didokumentasikan dalam laporan kegiatan, artikel ilmiah, dan publikasi media massa, dengan harapan dapat menjadi solusi inovatif bagi usaha rumah tangga lainnya untuk meningkatkan daya saing.
Rancang Bangun Antena Mikrostrip Rectangular Patch dengan Substrate Ganda
Authors: Fernandez Rudy , Hadiguna Rika Ampuh
Published: January 2025

Penelitian ini bertujuan untuk merancang bangun antena mikrostrip dengan bandwith yang lebih lebar agar dapat bekerja pada pita frekuensi 40 LTE. Substrat ganda  digunakan untuk mengatasi karakteristik bandwidth sempit dari antenna mikrostrip. Substrat yang ditambahkan memiliki jenis dan ukuran yang sama dengan substrat pada antena elemen tunggal yaitu FR4 yang memiliki konstanta dielektrik 4,4 dan ketebalan 1,6 mm.
Thinking about the creative heritage of F. M. Dostoevsky in the works of L. D. Zinovieva-Annibal
Authors: Wang Liuyang
Published: January 2025

The article is devoted to the comprehension of philosophical, aesthetic and moral ideas in the subsequent literature on the example of L.D. Zinovieva-Annibal's work. The article analyzes the works of L. D. Zinovieva-Annibal, whose childhood is presented in an unusual, often contradictory light. The similarity of approaches of Dostoevsky and Zinovieva-Annibal to the depiction of children's self-consciousness, children's cruelty and fantasies is noted. The works of Zinovieva-Annibal, written during the revolutionary events of 1905-1907, are also marked by the influence of Dostoevsky, his understanding of the ways of building a future just society. In this connection, the issues of freedom, overcoming individualism, and the tragic consequences of revolutionary violence are brought to the forefront. The stories “ You Help!” and “ Behind Prison bars” are in the center, in which the inner contradictions of the heroes are exposed, the split of personality and loss of self-identification are shown, which is confirmed by the establishment of the motive of the hero's inner conflict, similar to Raskolnikov, for whom the external punishment is only a reflection of the destruction of his inner world. The novelty of the article lies in the fact that the embodiment of Dostoevsky's ideological heritage in the work of Zinovieva-Annibal is studied comprehensively with reliance on the analysis of the image of the child and the image of the “underground man”. As a result of the study it was found that the principles of Dostoevsky's poetics underlie the interpretation of the spiritual world of the heroes of Zinovieva-Annibal's works, which undoubtedly arose in the course of discussions with her husband, V.I. Ivanov, about the ideological and semantic content of Dostoevsky's works, who for the Symbolist poet was an iconic figure of Russian spiritual life.
Nietzsche's Poethics: Poetry as a Way of Life in 'The Gay Science'
Authors: Mills Philip
Published: January 2025

The notion of poethics has been used to approach the way in which forms of language and forms of life are interdependent and to reveal the ethical dimension of poetics. However, the interaction must go both ways; there must not only be an ethical dimension to poetics, but also a poetic dimension to ethics. To what extent is ethics dependent on poetics? In this essay, I argue that Nietzsche’s life-affirming ethics can be understood only in this poethical framework. The specificity of Nietzsche’s ethics, and why it is so difficult to locate on the spectrum of ethical theories, lies in the fact that his ethics is a poetics. By focusing mainly on The Gay Science, I explore the interaction between ethics and poetics that lies at the heart of Nietzsche’s ethical thought. Both poetics and ethics involve the question of value, and a poetic ethics (a poethics) reveals that the creation of ethical value is something necessarily poetic. Nietzsche’s ethics of creation is not a mere theory, but a poetic way of life.
A Review of Nutritional and Health Risk Factors for Low Birth Weight Infants in Indonesia
Authors: Nurwati Yuni , Hardinsyah Hardinsyah , Marliyati Sri Anna , Santoso Budi Iman , Angraini Dewi
Published: January 2025

This review aimed to identify the determinants of nutritional and health factors associated with high risk of Low Birth Weight (LBW) among infants in Indonesia. The review was conducted systematically based on all articles published between 2012–2022 in PubMed, ScienceDirect, and SAGE databases. In the end, four articles were used in this review. The results showed that potential risk factors associated with LBW are maternal nutritional factors such as Mid-Upper Arm Circumference (MUAC) (25%) and pre-pregnancy Body Mass Index (BMI) (50%), and maternal health factors that can be assessed during routine Antenatal Care (ANC). Therefore, identification of risk factors for LBW is important to minimize the incidence of LBW.
Diet Quality Index of Infants Aged 6–9 Months of the Baduy Luar Ethnic Group in Lebak Regency, Indonesia
Authors: Vidyarini Andra , Muzakir Haris
Published: January 2025

The study aim was to determine the quality of food consumption using the Diet Quality Index for Infants aged 6 to 9 months from Baduy Luar Ethnic Group. The study was conducted in 16 hamlets of Kanekes Village and the sample size was 79 infants. The data were consumption data of infants for one week based on Semi Quantitative Food Frequency Questionnaire (SQ-FFQ). Diet quality results are classified into good, fair and poor. Most of the toddlers consumed breast milk and had low intake of protein, vegetables, fruits while their carbohydrate consumption was in accordance with recommendations. This study shows that quality of food consumption is not associated with nutritional problems in infants.
Evolving Dynamics of Moderate Islamic Discourse on Indonesian Social Media
Authors: Ghufron Hamzah  , Ahmad Muttaqin  , Muhammad Irsad  , Fouad Larhzizer
Published: January 2025

Social media not only creates a new public sphere for the expression of religious activities but also serves as a contested arena for religious discourse. In Indonesia, one of the key discourses under contention is moderate Islamic discourse. This article addresses two primary questions: First, what forms does contested moderate Islamic discourse take on social media, and what strategies are employed in these contests?.  Second, what factors contribute to the emergence of these contestations surrounding moderate Islamic discourse on social media?. Using Fairclough’s critical discourse analysis as a theoretical framework, this research explores qualitative data gathered through the observation of YouTube videos. The findings indicate that the contestation of moderate Islamic discourse on YouTube occurs not only between traditional and new religious authorities, as is often assumed, but also among traditional religious authorities themselves. These groups compete to articulate the true and ideal meaning of moderate Islam. The contestation is driven by a combination of ideological, economic, political, and socio-cultural factors that influence the digital sphere in Indonesia.
Жестовые нотации и их сравнительный анализ
Authors: МЯСОЕДОВА М А. , МЯСОЕДОВА З П.
Published: January 2025

Дано описание жестов и жестового языка как средств невербальной коммуникации людей с потерей слуха. Приведён краткий обзор существующих жестовых нотаций, предназначенных для фиксации жестов в письменной форме с использованием в них буквенных, цифровых и различных графических элементов. Проведён сравнительный анализ данных жестовых нотаций в соответствие с их характеристиками применительно к описанию русской жестовой речи. Обоснован выбор системы SignWriting для записи русской жестовой речи, модифицированной с учётом её специфики. Описаны особенности системы SignWriting, унифицированные знаки и правила которой позволяют наиболее компактно и точно фиксировать пространственно-временную форму жестов. Создан словарь наиболее употребительных жестов русского жестового языка различной тематики в письменной форме с использованием знаков системы SignWriting.

In this paper we describe gestures and sign language as means of non-verbal communication of people with hearing loss. We give a brief overview of existing sign language notations on currently, designed to depict gestures in a written form using in them alphabetic, digital and various graphic elements is given. We present comparative analysis of their sign language notations in accordance with their characteristics as applied to the description of Russian sign language. We argue that SignWriting system, modified for our needs, is a good choice to record Russian sign language. We describe features of the SignWriting system are described, the unified signs and rules of which allow the most compact and accurate fixation of the space-time form of gestures for the deaf. We created a dictionary of the most common gestures of Russian sign language of various topics; the dictionary is given in a written form using signs of SignWriting system.
Mathematical PROGRAMS modernization based on Russian and international standards
Authors: Zakharova Irina V , Kuzenkov Oleg A
Published: January 2025

Russian education standards have come a long way from being extremely detailed and regulating the content of education programs at all levels to the current state when there is a great freedom for universities in defining its education programs. The downside of that freedom is too general formulations of these competences and absence of framework requirements for the scope and content of individual parts of educational programs for the various types of training. This raises the problem of preserving the unity of educational space in Russia and the traditionally high level of teaching mathematics in Russian universities. Russian scientific and educational community together with industry and business are currently looking for the ways to solve this problem. In the paper, the experience of the modernization educational programs in the field of information and communication technologies is considered. The methodology of creation of valid assessment tools funds to check formation of competences is presented. The presented results are based on the methodology of international and Russian scientific and methodological projects.

Российские образовательные стандарты прошли достаточно длинный путь от максимальной подробности и регламентации содержания образовательных программ, эволюционируя в сторону наибольшей свободы вузов при их проектировании. Недостатком этой свободы являются слишком общие формулировки этих компетенций и отсутствие даже рамочных требований к объему и содержанию отдельных частей образовательных программ для различных образовательных программ. Это порождает проблему сохранения единства образовательного пространства в России и традиционно высокого уровня преподавания математики в российских университетах. Российское научное и образовательное сообщество совместно с промышленностью и бизнесом в настоящее время ищут пути решения этой проблемы. В статье рассматривается опыт модернизации образовательных программ в области информационно-коммуникационных технологий. Представлена методология создания средств достоверной оценки инструментов для проверки формирования компетенций. Представленные результаты основаны на методологии международных и российских научно-методических проектов. В настоящее время полученные результаты апробации методологии показали, что выбранные методы модернизации являются эффективным инструментом решения заданных математических задач в инженерном образовании в российских университетах, и, следовательно, студенты станут более адекватно соответствовать потребностям рынка труда.
ПРИМЕНЕНИЕ ИНФОРМАЦИОННЫХ ТЕХНОЛОГИЙ В ПРОСТРАНСТВЕ МЕЖДУНАРОДНЫХ ГРУЗОВЫХ ПЕРЕВОЗОК
Authors: СИРИНА Н Ф. , ЗУБКОВ В В.
Published: January 2025

Участие железнодорожной отрасли в международных перевозках заключается в том, что она представляет основной вид магистрального транспорта, и основная часть грузооборота приходится на ее долю. Это актуализирует необходимость развития и реализации экспортного потенциала России на основе консолидации собственно железнодорожного транспорта с иными участниками транспортной производственной системы и интеграции его в международные транспортно логистические системы. В статье рассматривается проблема реализации экспортных и транзитных возможностей России в пространстве международных перевозок. Основное  внимание уделено поиску нового пути эффективного развития железнодорожной транспортной системы в сегменте рынка международных грузовых перевозок, идея, которой заключается в консолидации высокотехнологических информационных систем как будущих, так и действующих участников перевозочного процесса, железнодорожной и других транспортных инфраструктур. Авторами статьи разработана и предложена к внедрению автоматизированная система информирования грузовладельцев о приближении срока окончания действия фитосанитарного сертификата. Данная система, повышает эффективность эксплуатационной работы путем исключения  длительных простоев подвижного состава на пограничных железнодорожных станциях, в результате чего повышается их пропускная способность, автоматизирует процесс обработки и передачи информации о состоянии груза и перевозочных документов от участников транспортно обеспечивающих функций до потребителя транспортных услуг.

ailway carriage is the main type of long-haul traffic in international carriage, thus, the key part of cargo turnover accounts for railway traffic. This makes it relevant to develop and actualize the Russian export potential by means of consolidating railway traffic and other participants of the transport production system and integrating it with international transport AND logistics systems. The article considers cargo export and transit issues in Russia in the framework of international cargo carriage. Particular attention is paid to the search of a new way of the efficient development of the railway transport system in the market sector of international cargo carriage. The key idea is to consolidate high-technology information systems of both the future and existing carriage participants from the railway and other transport infrastructures. The authors developed and suggested introducing an automated system of informing cargo owners on the expiring certificate of fumigation. Such system improves the operational efficiency by means of avoiding long periods of rolling stock downtime at border railway stations. This provides for their better capacity, automated processing and transfer of the information on the cargo condition and carriage documents from the transporting agents to the transport service consumers.
How to Correct Erroneous Symmetry-Breaking in Coarse-Grained Constant-pH Simulations
Authors: Beyer David , Blanco Pablo M. , Landsgesell Jonas , Kosovan Peter , Holm Christian
Published: January 2025

The constant-pH Monte Carlo method is a popular algorithm to study acid-base equilibria in coarse-grained simulations of charge regulating soft matter systems including weak polyelectrolytes and proteins. However, the method suffers from systematic errors in simulations with explicit ions, which lead to a symmetry-breaking between chemically equivalent implementations of the acid-base equilibrium. Here, we show that this artifact of the algorithm can be corrected a-posteriori by simply shifting the pH-scale. We present two analytical methods as well as a numerical method using Widom insertion to obtain the correction. By numerically investigating various sample systems, we assess the range of validity of the analytical approaches and show that the Widom approach always leads to consistent results, even when the analytical approaches fail. Overall, we provide practical guidelines on how to use constant-pH simulations to avoid systematic errors, including cases where special care is required, such as polyampholytes and proteins.
Development of a Manufacturing Process for S-892216 Part II: Improvements Toward Commercially Feasible Process
Authors: Le Thien Phuc , Kawajiri Takahiro , Sahara Naoto , Kato Go , Hosoya Masahiro , Oohara Tadashi , Agura Kazushi , Ohara Takafumi , Goda Satoshi
Published: January 2025

In this study, we described developing a refined manufacturing process for S-892216, a second-generation COVID-19 therapeutic agent currently under development. The focus of this research was on the feasibility of commercial manufacturing. In particular, we developed a manufacturing process that facilitates the stable acquisition of a specific crystal form for intermediate or maximum reaction efficiency using flow chemistry, eliminating the need for excessive extraction, concentration, and purification operations. Compared to the first-generation process used during early-phase clinical trials, the overall yields (increasing from 41% to 62%) and PMI values (decreasing from 323 to 210) improved significantly. These advancements underscore the potential of the second-generation process for S-892216 to strengthen the supply chain of COVID-19 therapeutics.
The Role of Surface Hydroxyls in Dehydration and Dehydrogenation of Formic Acid on Fe3O4(001)
Authors: Sharp Marcus , Nguyen Hoan , Lee Christopher , Sauter Eric , Wang Yuemin , Wöll Christof , Jackson Benjamin , Lee Mal Soon , Kay Bruce , Raugei Simone , Arnadottir Liney , Dohnálek Zdenek
Published: January 2025

Understanding the role of surface structure and hydroxylation in catalytic reactions on metal oxide surfaces is important for developing a mechanistic insight into the complex interface processes. Here, we investigate the reactivity of formic acid on reconstructed Fe3O4(001) using a combination of X-ray photoelectron spectroscopy, infrared reflection absorption spectroscopy, temperature-programmed reaction spectroscopy, low energy electron diffraction, and electronic structure calculations. We find that formic acid initially dissociates at low temperatures (< 80 K) into bidentate formate and a hydroxyl up to an initial dosed coverage of two HCOOH per Fe3O4(001) unit cell. At higher temperatures (> 450 K), formate largely decomposes along the dehydration pathway, producing CO and H2O, with dehydrogenation to CO2 being a minority side reaction. As a first step, water formation leads to surface oxygen extraction via the Mars-van Krevelen mechanism. Computational studies reveal formate embedded in oxygen vacancies as a key intermediate in the CO formation mechanism. CO formation proceeds via two reaction pathways with desorption that peaks at 530 K on the hydroxyl-rich surface and 560 K on the hydroxyl-deficient surface. Atomic hydrogen coadsorption experiments and ab initio calculations reveal that the presence of surface hydroxyls reduces the CO formation barrier. These results highlight the complex interactions between substrate and intermediate species occurring during reactions on metal oxide surfaces.
Polska reforma walutowa z 1924 roku
Authors: Witczak Zbigniew
Published: January 2025

Przedmiot badań: W 2024 r. przypada setna rocznica wprowadzenia nowej waluty w odrodzonym państwie polskim. Ten wieloaspektowy proces był niełatwym przedsięwzięciem, który zrealizowany został przez Władysława Grabskiego i jego rząd, co wpisywało się w szerszy kontekst reform podejmowanych po 1918 r. w niepodległej Polsce. Przedmiotem badań niniejszego artykułu jest reforma walutowa, którą przeprowadzono w Polsce w 1924 r.
Cel badawczy: Celem pracy jest przedstawienie reformy walutowej przeprowadzonej w Polsce w 1924 r., omówienie przyczyn, założeń i sposobów jej przeprowadzenia, w tym jej prawnych i technicznych aspektów. Artykuł jest próbą odpowiedzi na pytanie, czy w wyniku jej wprowadzenia udało się osiągnąć cele, jakie zakładała.
Metoda badawcza: Głównymi metodami badawczymi zastosowanymi w artykule są krytyczna analiza literatury przedmiotu oraz analiza historyczna aktów prawnych wprowadzonych w trakcie realizacji reformy.
Wyniki: Reformy, powszechnie znanej pod nazwą reformy walutowej Grabskiego, nie można było uniknąć. Ziemie, które weszły w skład Polski, a które przedtem były składowymi innych organizmów państwowych oraz gospodarczych, wymagały uporządkowania na wielu płaszczyznach, łącznie z potrzebą stabilizacji i unifikacji monetarnej. Stworzenie własnej waluty było jednym z zadań priorytetowych. Sam proces napotkał liczne trudności, jednak reforma dała podwaliny do kreowania polityki gospodarczej młodego państwa.
Annual report on migration and asylum 2023
Authors: Potter Dervla , Murphy Keire , Sheridan Anne , de Barra Yazmin
Published: January 2025

The Annual report on migration and asylum 2023: Ireland provides a detailed overview of the key developments in migration and asylum in Ireland in 2023. It includes statistics, significant policy developments and debates, research and notable case law on a comprehensive range of migration-related topics. It is the 20th report in the series and complements the European Migration Network’s (EMN) series of European annual reports, which give an overview of developments across EMN Member and Observer Countries.

While Ireland’s migration and asylum landscape is constantly changing, significant developments occurred in 2023. Ireland’s population continues to rise, with an estimated population of 5.38 million in 2024, a 1.9% increase from the previous year. Immigration and emigration both increased in the 12 months to April 2024 according to the Central Statistics Office (CSO), although immigration was still slightly lower than the peak in 2007. During this time, Ireland welcomed arrivals from Ukraine following the continued Russian invasion, albeit in lower numbers than in 2022, and experienced continued high levels of people seeking international protection in Ireland. This report is also set against a backdrop of other social, economic and political developments such as increased costs of living, a housing crisis and increase in anti-migrant sentiment. While not all of these are covered in the report, they are relevant to understanding the context at the time.

Policy and legislative changes were also prominent in 2023, spanning various aspects of migration and asylum such as labour migration, international protection, temporary protection, integration, human trafficking, irregular migration, visas and return. Developments also occurred at multiple levels, from the national to European and international levels.

This report serves as a comprehensive resource, providing detailed statistics, policy and legislative changes, summaries of recent research and significant case law. It is intended to be a reliable reference for readers seeking to understand these elements for the year of the report.
BIBLIOMETRIC ANALYSIS OF RISK TOLERANCE: GLOBAL COLLABORATION AND THEMATIC EVOLUTION
Authors: Ayu Desi Indrawati , Nyoman Triaryati
Published: January 2025

This study aims to analyze the development of research on risk tolerance over the past two decades, focusing on collaborative networks among authors and countries, thematic evolution, and new research opportunities. The method used is bibliometric analysis based on R software and VOS Viewer. The research population includes 833 articles related to risk tolerance identified from the Scopus database. The study was conducted through network visualization, thematic clustering, and thematic evolution mapping. The results show that publications on risk tolerance have increased by 15% annually, with the United States as the primary contributor. The main recurring themes include risk assessment, decision-making, and financial risk tolerance. However, there is a gap in integrating the risk tolerance theme with broader concepts such as financial literacy. The analysis also indicates increased international collaboration, particularly in North America, Europe, and Asia, but with limited cooperation in Latin America and Africa. This study recommends further exploration of the relationship between risk tolerance, financial literacy, and technology-based decision-making. Additionally, it suggests enhancing cross-regional collaborations to broaden the scope and impact of research in this field.
MANAGEMENT INFORMATION SYSTEMS ON SMALL BUSINESS STARTUPS AND THEIR STRATEGY AND PERFORMANCE
Authors: Rakhmawati  , Yudhi Prasetya Mada
Published: January 2025

Management Information System (MIS) is an information system intended for use by the management of an organization. MIS generally collects summary data from various departments or subsystems of an organization and presents it in a form that helps management make better decisions. The meaning of MIS is represented by three things. “Management” – information systems are built for management and not for operational staff. “Information System” – information systems that deal with the sourcing, organizing, and managing of required data and presenting it in a desired format that is useful for a purpose.
Importing Delights or Dangers?: Films, Television, Toys, and the Creation of Children’s Consumer Culture in New Zealand, 1935-2024
Authors:   , Wright Isis
Published: January 2025

The thesis traces the development of children’s consumer culture in New Zealand from the 1930s to the present. It begins with the merchandising efforts of local entrepreneurs to appeal to boys’ desires for cars, and girls for Hollywood glamour as Shirley Temple and Walt Disney became the inspiration for toys and related merchandise. Initially playing with replicas of foreign-made toys in the 1930s, New Zealand children became increasingly attracted to imported toys due to the arrival of television in the 1960s. By the late 1970s when Star Wars arrived, they were immersed in a global children’s consumer culture that often involved different forms of media with associated toys created by Disney, Mattel, and other global enterprises. In the 1990s programme-length commercials like Teenage Mutant Ninja Turtles (TMNT) filled up television schedules and added must-have items to toy boxes, while New Zealand productions and products found it difficult to compete for audiences and consumers.

The explosive popularity of the heavily marketed and hyped Barbie indicates that the relationship between trans-media and merchandise is more powerful than ever. Today it encompasses nostalgic adults reliving their childhood amusements as evidenced by The Super Mario Bros. Movie which was only $83,000,000 behind Barbie in the global box office. Super Mario competed against a slew of male-oriented blockbusters, like Teenage Mutant Ninja Turtles: Mutant Mayhem, while Barbie’s main competition was Disney’s live-action The Little Mermaid. The merchandising machine of Mattel with its dolls, housewares, beauty items, and bags encouraging customers to channel their inner Barbie was also adept at extracting profits from its Disney rival with a Little Mermaid doll collection. Toys, Hollywood films, and streaming services like Netflix continued to associate playing with profits and the promise of enjoyment for New Zealand children and adult consumers.

The emergence of children’s consumer culture is examined through an analysis of influential films, television, toys, and advertising from the 1930s to the present concentrated on trans-media entertainment and associated merchandise. A survey of contemporary New Zealanders enquires into their relationship with globally influenced children’s consumer culture, and the extent of their continued attachment to childhood thrills derived from imported products and trans-media offerings. The thesis reveals that parental and children’s consumption patterns in New Zealand demonstrate the impact of global children’s consumer culture transmitted by Hollywood films, imported television, and the marketing of toys that associate enjoyment and status with the purchase of cultural and commodity imports.
Japanese children's experiences in Aotearoa New Zealand early childhood education and care settings
Authors:   , Takemoto Madoka
Published: January 2025

Aotearoa New Zealand is now regarded as a superdiverse country. Early childhood education and care (ECEC) settings in Aotearoa New Zealand reflect this diversity presenting challenges and complex situations for children and adults to navigate. However, there is a paucity of research in this area, along with understanding the experiences of children from ethnic minorities, including Japanese. This study investigated Japanese children’s experiences in New Zealand ECEC contexts and explored how these children responded to and negotiated situations that are culturally challenging in their ECEC settings.

Using a qualitative multiple-case study approach, I focused on five Japanese children in separate ECEC settings across New Zealand. Data was gathered through observing each child, interviewing their parents and teachers/educators, and analysing national and international frameworks that are part of the broader context in which ECEC settings are located. Rogoff’s three foci of analysis (2003) were used to analyse the children’s experiences from multiple perspectives including personal, interpersonal, and cultural-institutional. I also drew on concepts from critical multicultural perspectives as a way of interrogating the position of children in a minority group – i.e., Japanese – in a predominantly Western and bicultural education system.

The findings suggest that Japanese children experienced complex cultural situations that created challenges and influenced their choice of cultural identities while negotiating their sense of belonging in their ECEC communities. Furthermore, the findings suggest that there are multiple ways of being Japanese. The children’s identities were largely fluid and changed in response to the current situation and the opportunities and challenges it afforded. I argue that the Japanese concept of Ibasho – referring to the place where people can be themselves – was crucial to understanding shifts in the children’s sense of belonging and in their expressions of identity.

My study contributes to understanding the diversity of Japanese children’s experiences in New Zealand ECEC centres. It signals the importance of avoiding overgeneralizations of ethnic identities and the need for teachers to be supported in their work in superdiverse settings.
DETECTION OF NON-MELANOMA SKIN CANCER BY DEEP CONVOLUTIONAL NEURAL NETWORK AND STOCHASTIC GRADIENT DESCENT OPTIMIZATION ALGORITHM
Authors: Sahu Premananda , Kumar Mohapatra Srikanta , Kumar Sarangi Prakash , Mohanty Jayashree , Kumar Sarangi Pradeepta
Published: January 2025

Nowadays, people are doing a lot of work outside for a living. When they roam outside, there may be a chance to enter types of bacteria or fungi in our bodies through the skin by either the polluted gases from the vehicles or the ultraviolet rays emitted by the Sun. The expansion of skin problems for human beings has emerged as a significant problem, and the successful investigation has been observed as an arduous task for clinical experts or dermatologists. This paper has furnished an automatic diagnosis of skin cancer earlier with the help of deep learning techniques and the skin-related images captured by the Skin Biopsy test. In this approach, we detected non-melanoma using ensemble techniques related to deep convolutional neural networks and the stochastic gradient descent optimization technique. Furthermore, we used HAM 10000 as the data set for training and testing purposes, as well as the feature extraction technique Principal Component Analysis. This work also investigated a comparison of previous models. It was found that the proposed model gained an approximation of 98.57 % classification accuracy.
Educational Evaluation with Large Language Models (LLMs): ChatGPT-4 in Recalling and Evaluating Students’ Written Responses
Authors: S. Jauhiainen Jussi , Bernardo Garagorry Guerra Agustin
Published: January 2025

Aim/Purpose: This article investigates the process of identifying and correcting hallucinations in ChatGPT-4’s recall of student-written responses as well as its evaluation of these responses, and provision of feedback. Effective prompting is examined to enhance the pre-evaluation, evaluation, and post-evaluation stages.

Background: Advanced Large Language Models (LLMs), such as ChatGPT-4, have gained significant traction in educational contexts. However, as of early 2025, systematic empirical studies on their application for evaluating students’ essays and open-ended written exam responses remain limited. It is important to consider pre-evaluation, evaluation and post-evaluation stages when using LLMs.

Methodology: In this study, ChatGPT-4 recalled 10 times 54 open-ended responses submitted by university students, making together almost 50,000 words, and assessing and offering feedback on each response.

Contribution: The findings emphasize the critical importance of pre-evaluation, evaluation, and post-evaluation stages, and in particular prompting and recalling when utilizing LLMs for educational assessments.

Findings: Using systematic prompting techniques, such as Chain of Thought (CoT), ChatGPT-4 can be effectively prepared to accurately recall, evaluate, and provide meaningful, individualized feedback on students’ written responses, following specific instructional guidelines.

Recommendations for Practitioners: Proper implementation of pre-evaluation, evaluation and post-evaluation stages and testing of recall accuracy are important when using ChatGPT-4 for evaluating students’ open-ended responses and providing feedback.

Recommendation for Researchers: Recall accuracy needs to be tested, and the prompting process carefully revealed when using and researching LLMs like ChatGPT-4 for educational evaluations.

Impact on Society: As LLMs continue to evolve, they are expected to become valuable tools for assessing student essays and open-ended responses, offering potential time and resource savings for educators and educational institutions.

Future Research: Future research should explore the use of various LLMs across different academic fields and topics to better understand their potential and limitations in educational evaluation.