bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of the World Inflammatory Bowel Disease Day and Crohn’s and Colitis Awareness Week on Population Interest Between 2016 and 2020: Google Trends Analysis (Preprint)
Authors: Silangcruz Krixie , Nishimura Yoshito , Czech Torrey , Kimura Nobuhiko , Hagiya Hideharu , Koyama Toshihiro , Otsuka Fumio
Published: October 2021

BACKGROUND

More than 6 million people are affected by inflammatory bowel disease (IBD) globally. The World IBD Day (WID, May 19) and Crohn’s and Colitis Awareness Week (CCAW, December 1-7) occur yearly as national health observances to raise public awareness of IBD, but their effects are unclear.

OBJECTIVE

The aim of this study was to analyze the relationship between WID or CCAW and the public health awareness on IBD represented by the Google search engine query data.

METHODS

This study evaluates the impact of WID and CCAW on the public awareness of IBD in the United States and worldwide from 2016 to 2020 by using the relative search volume of “IBD,” “ulcerative colitis,” and “Crohn’s disease” in Google Trends. To identify significant time points of trend changes (joinpoints), we performed joinpoint regression analysis.

RESULTS

No joinpoints were noted around the time of WID or CCAW during the study period in the search results of the United States. Worldwide, joinpoints were noted around WID in 2020 with the search for “IBD” and around CCAW in 2017 and 2019 with the search for “ulcerative colitis.” However, the extents of trend changes were modest without statistically significant increases.

CONCLUSIONS

These results posed a question that WID and CCAW might not have worked as expected to raise public awareness of IBD. Additional studies are needed to precisely estimate the impact of health observances to raise the awareness of IBD.
Perspectives of patients with prostate cancer on self-management support through mHealth and health-coaching: an interpretive description (Preprint)
Authors: Øbro Louise Faurholt , Osther Palle Jörn Sloth , Ammentorp Jette , Pihl Gitte Thybo , Heiselberg Kasper , Krogh Peter Gall , Handberg Charlotte
Published: October 2021

BACKGROUND

Observational management, such as Active Surveillance and Watchful Waiting, is shown to be feasible for men with low-risk localized prostate cancer and a safe alternative to aggressive treatment. During observational management, treatment is postponed until the disease progresses, which often never happens. However, approximately 90% of patients with low-risk disease choose aggressive treatment, owing to anxiety. Strategies to address this are needed for optimal management of this population and to improve quality of life in men with low-risk localized prostate cancer. A review highlights that mHealth in combination with health-coaching can benefit from each other in order to enhance patients’ self-management and improve wellbeing.

OBJECTIVE

The objective of this study was to explore the patients’ experiences and perspectives of an intervention offering self-management support through different mHealth devices and health-coaching, in order to investigate what supported them in making sustainable changes for improving well-being.

METHODS

We used an interpretive description approach, combining semi-structured interviews with 13 purposively selected prostate cancer patients and participant observations of patient-coach interactions in coaching sessions. The interviews were transcribed and analyzed. Self-determination theory were used as a theoretical lens. Field notes and the coaching notes from each session were used to orient data generation and confirm or challenge the analysis.

RESULTS

In general, our analysis revealed that the men’s identity seemed to influence their experience and perspective of the self-management support through mHealth and health-coaching in clinical practice. The men´s individual experiences and perspectives indicated that they placed themselves in a dynamic continuum of sustaining and/or repressing own identity. Our analysis revealed four interacting themes all related to the identity of the men.

CONCLUSIONS

In order for the men with prostate cancer to achieve wellbeing, we found it important for the men to be able to sustain own identity, when offered a self-management intervention. Motivation and autonomy were important aspects in order for the men to sustain own identity throughout the intervention. In contrast, demotivation and paternalism could result in an experience of having to repress own identity.
Automatic Depression Detection of Mobile-Based Text-dependent Speech Signals Using a Deep CNN Approach: A Prospective Cohort Study (Preprint)
Authors: Kim Ahyoung , Jang Eun Hye , Lee Seung-Hwan , Choi Kwang-Yeon , Park Jeon Gyu , Shin Hyun-Chool
Published: October 2021

BACKGROUND

In the future, automatic diagnosis of depression based on speech could complement mental health treatment methods. Previous studies have reported that acoustic properties can be used to recognize depression, including mel-frequency cepstrum coefficients (MFCCs) applied to speech recognition. However, there are few studies in which these characteristics allow differential diagnosis of patients with depressive disorder.

OBJECTIVE

This paper proposes a framework to help with automatic depression detection in a mobile environment where speech data can be easily obtained. Specifically, we recorded speech data by performing a predefined text-based speech reading task on mobile, investigated whether the recorded data can screen for depression, and proposed a deep learning-based framework that helps in automatic depression detection.

METHODS

We recruited 125 patients who met the criteria for major depressive disorder (MDD) and 113 healthy controls without current or past mental illness. Participants' voices were recorded on smart-phone while performing the task of reading predefined text-based sentences. We investigated the differences in the voice characteristics between MDD and healthy control groups using statistical analysis. We also investigated the possibility of automatic depression detection using the proposed log mel (LM) spectrogram-based deep Convolutional Neural Networks (CNN) architectures and machine learning models.

RESULTS

We found that there were statistically discernable differences between MDD and control groups in the MFCC features extracted through the utterances of reading predefined text-based sentences. Moreover, the best accuracies achieved with LM spectrogram-based CNN and softmax classifier on the speech data are 80.00% accuracy. Our results show that the deep-learned acoustic characteristics lead to better performances of classifiers than those using the conventional approach.

CONCLUSIONS

Conclusions: In conclusion, this study suggests that the analysis of speech data recorded while reading text-dependent sentences could help predict depression status automatically by capturing characteristics of depression. Our method can contribute to an approach that allows individuals to easily and automatically assess their depressive state anytime, anywhere, without the need for experts to conduct psychological assessments on-site.
Tipos de hábitat: definiciones y desafíos para su medición a partir del caso de la aglomeración Gran Buenos Aires
Authors:   Consejo Nacional de Investigaciones Científicas y Técnicas, Marcos Mariana
Published: October 2021

El artículo se inserta en el campo de estudio de los tipos de hábitat (o tipos de poblamiento). A pe-sar de que estos entornos constituyen escenarios sociodemográficos con gran potencial diferen-ciador en las grandes aglomeraciones urbanas de América Latina, el uso de la perspectiva no se encuentra muy extendido. Aquí se abordan los desafíos para arribar a definiciones operacionales adaptadas a las especificidades de una ciudad y los condicionamientos derivados de la disponi-bilidad de datos. A partir del caso de Buenos Aires, se busca contribuir en dos niveles: en el más general, se aporta a las bases metodológico-conceptuales y a las condiciones de replicabilidad en otros contextos geográficos y temporales; y en el nivel del caso de Buenos Aires, se realiza la primera clasificación de su territorio en tipos de hábitat.
Data Base Management Systems Query Optimization Techniques for Distributed Database Systems
Authors: Barot Yashvi
Published: October 2021

Abstract: The fundamental goal of this postulation is to introduce various models for single also as numerous inquiry handling in the Distributed data set framework which brings about less question handling cost. One of the significant issues in the plan and execution of Distributed Information Base Management Systems (DDBMS) is productive inquiry handling. The objective of dispersed inquiry improvement decreases to minimization of measure of information to be communicated among destinations for handling a given inquiry. The issue of question handling in DDBS (1 1) has been concentrated broadly in writing. In the greater part of calculations, the capability of the question will contain a grouping of tasks. In such cases, while executing tasks from right to left, as per the request for tasks in arrangement, the aftereffect of an activity might be an operand to the next activity. Since the tasks are subject to each other, at a moment in particular one activity at one site will be executed despite the fact that the climate is dispersed. Then frameworks at any remaining locales will be inactive for this inquiry. Another model, Totally Reducible Relation Model (CRK Medel), which permits parallelism and processes numerous tasks all the while at all important locales is introduced. It is expected that the tasks are in the type of conjunctions. So every activity can be handled freely. In this model at some moment, relations at every single significant site will be totally diminished by relating sets of every appropriate activity (Determinations, Semijoins and Joins) all the while. Thus, every connection will be checked just a single time to deal with all appropriate tasks by decreasing VO cost.
Application of Toyota Way Incorporating Kaizen, Kaikaku and 5S in Agricultural Sector
Authors: Moi Wong Ai
Published: October 2021

Abstract: A noble operational framework – 2K5S, a modified form of Toyota production system (TPS) incorporating Kaizen, Kaikaku and 5S is introduced in this paper. Kaizen is continuous improvement concept implementing a small step at a time to produce a small or moderate improvement in productivity. Kaikaku is a moderate innovative approach implementing new work method or means to produce a drastic improvement in productivity by eliminating wastes at the same time. The 2K5S is then implemented in the operations of a pineapple farm and a series of case studies are conducted. The outcomes of the case studies have revealed that through the introduction and implementation of the 2K5S operational framework, some significant organisational improvements have been witnessed. Apart from significantly increment in productivity, other advantages achieved including increasing in effectiveness and efficiency in the operational processes, improved visual management of the process, improved operational health and safety and morale of the workers, improved housekeeping, waste elimination and process standardization. The outcomes of this study have demonstrated that 2K5S is a powerful and practical operational framework model which is applicable for agricultural organisation. Keywords: Toyota production system (TPS), 2K5S, Kaizen, Kaikaku, 5S, continuous improvement, agricultural sector.
Seismic Analysis and Comparative Study of Brick Wall, Shear Wall and Bare Frame on G+12 High Rise Building
Authors: Verma Ankur
Published: October 2021

Abstract: Today, larger part of designs around us are built up concrete cement (RCC) outlined constructions. To forestall harm because of quake there is a need to foster powerful procedure to expand the strength and flexibility of elevated structures. Shear wall are steadier and more pliable and thus can bear more even loads. In this paper, we have proposed a relative report between block facade, shear divider and uncovered casing by using ETABS programming. This review is essentially centered around seismic conduct of G+12 building. The outcomes are talked about as far as base shear, sidelong relocation, story float, story solidness and normal period for every one of the three models. We find that shear wall has least parallel uprooting and least time span when contrasted and block facade and uncovered edge. Likewise, we track down that the shear divider model is more adaptable because of lesser float when contrasted and different models. The upsides of removal and float for shear wall is likewise not as much as block facade since the tallness of the structure increments. Keywords: shear wall, bare frame, Response spectrum, Earthquake, ETABS
DOES IMMERSIVE VIRTUAL REALITY INDUCE CYBERSICKNESS AND IMPACT EQUILIBRIUM COORDINATION?
Authors: Nurai Tamanna
Published: October 2021

Cybersickness continues to become a negative consequence that degrades the interface for users of virtual worlds created for Virtual Reality (VR) users. There are various abnormalities that might cause quantifiable changes in body awareness when donning an Head Mounted Display (HMD) in a Virtual Environment (VE). VR headsets do provide VE that matches the actual world and allows users to have a range of experiences. Motion sickness and simulation sickness performance gives self-report assessments of cybersickness with VEs. In this study a simulator sickness questionnaire is being used to measure the aftereffects of the virtual environment. This research aims to answer if Immersive VR induce cybersickness and impact equilibrium coordination. The present research is formed as a cross-sectional observational analysis. According to the selection criteria, a total of 40 subjects would be recruited from AVBRH, Sawangi Meghe for the research. With intervention being used the experiment lasted 6 months. Simulator sickness questionnaire is used to evaluate the after-effects of a virtual environment. It holds a single period for measuring motion sickness and evaluation of equilibrium tests were done twice at exit and after 10 mins. Virtual reality being used in video games is still in its development. Integrating gameplay action into the VR experience will necessitate a significant amount of study and development. The study has evaluated if Immersive VR induce cybersickness and impact equilibrium coordination. To measure cybersickness, numerous scales have been developed. The essence of cybersickness has been revealed owing to work on motion sickness in a simulated system.
MICRO AND NANOPARTICLES FOR THE DELIVERY OF GROWTH FACTORS IN DIABETIC WOUNDS
Authors: Sanju S
Published: October 2021

Diabetic wound (DW) is one of the leading complications of diabetes patients with a long history. It also puts an economic burden on people recovering from injuries to manage medication. The critical factors in the treatment of DW are infection, inflammation, and low oxygen level. Since these non-healing injuries are linked to the extended recovery process, current treatments are studied only for a short period. The areas covered in this article are an overview of DM, Pathophysiology of DW, stages of wound healing (Hemostasis, Inflammation, Proliferation, Maturation), the role of growth factor in diabetic wound healing, advantages of micro and nanoparticles over other drug delivery systems and micro and nanoparticles for the delivery of growth factors with different studies.
A NOVEL VALIDATED HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC STABILITY-INDICATING ASSAY METHOD IN REVERSE PHASE FOR ESTIMATION OF HYDROXYPROGESTERONE CAPROATE IN AN INJECTABLE FORMULATION.
Authors: Tiwari Vivek
Published: October 2021

A high-performance liquid chromatographic stability-indicating assay method in reverse-phase has been developed and validated for the quantitative measurement of Hydroxyprogesterone corporate in injectable formulation prepared in castor oil base containing excipient benzyl benzoate as preservative. The reverse-phase method was developed by using Sunfire C18 column having dimensions (150 x 4.6 mm x 5μm) with a mobile phase[A] comprised of water, acetonitrile, and Methanol mixed in 40:30:30 v/v ratio and mobile phase [B] comprised of water, acetonitrile, and Methanol mixed in 20:40:40 v/v ratio pumped gradient program at a flow rate of 1.0 ml/min where the thermostat of the column oven controlled at 30°C and sample compartment at 5°C. The injection volume is set at 20μL. Hydroxyprogesterone corporate has a retention time of 10 minutes with UV detection at 240 nm. The detector was showing linear response in a range of 0.25 μg/ml to 150 μg/ml for Hydroxyprogesterone corporate. The guidelines of the International Conference on Harmonization on guidance for industry (2005) validation of analytical procedures, text, and methodology Q2(R1) were followed for the validation of this novel method. For quantification of Hydroxyprogesterone corporate the developed method was found to be genuinely exact precise, accurate, linear, robust, rugged, stable. and cost-effective.
PHYTONUTRIENTS, ANTIOXIDANTS AND ANTI-INFLAMMATORY ANALYSIS OF PEPEROMIA PELLUCIDA
Authors: Fakayode Aderonke E
Published: October 2021

The effectiveness of fruits and vegetables in the management of various forms of ailments and disorders has been attributed to the presence of bioactive components. Most fruits and vegetables are only available for a season and perish easily. Peperomia pellucida is a seasonal vegetable that is usually available only during rainy season. The study investigated the nutritional contents, antioxidant and anti-inflammatory activities of Peperomia pellucida as well as the effects of drying on these activities. Methanolic extract of fresh and dried leaves and stem of Peperomia pellucida were subjected to phytochemical screening and nutritional analysis including estimation of soluble proteins, sugars and amino acids. Antioxidant analysis included vitamin C and vitamin E estimation, assay of DPPH-free radical scavenging activity and antioxidant reducing power while anti-inflammatory analyses included assay of membrane stability activity and albumin denaturation inhibition. All procedures were carried out using standard methods. Phytochemical analyses revealed the presence of a number of vital phytochemicals including alkaloids, flavonoids, cardiac glycosides, tanins, triterpenoids and xanthoproteins. Phytochemicals present in dried leaves of the plant were found to be higher than what obtained in the fresh leaves while fresh vegetables were found to have nutritional content (Vitamin E, Vitamin C, Protein, Soluble sugar and free amino acid) than the dried vegetable. Furthermore, both fresh and dired leaf extracts of P. pellucida exhibited a wide range of antioxidant and anti-inflammatory potentials which were found to be comparable to what obtained in standard drugs. Peperomia Pellucida is a vegetable of high nutritional value and has prospects of being used in the management of various diseases in which oxidative stress and inflammation are implicated. Furthermore, Processing (drying) of the vegetable elicits a great reduction in the nutritional contents. This could be due to dehydration and denaturation of the vital components of the vegetable.
MACHINE SHAFTS RECOVERY BY COMBINING ELECTROMECHANICAL PROCESSING WITH THE USE OF POLYMER MATERIALS
Authors:   Ogarev National Research Mordovian State University, Konakov Andrey V. , Kotin Aleksandr V.
Published: October 2021

Currently, one of the most acute problems of repair production is the lack of highly efficient, but at the same time easy-to-implement technological processes for restoring the landing surfaces of shafts and axles of machine mechanisms. The solution to this problem is in the combination of simple and inexpensive technological processes with the production of multilayer coatings with specified guaranteed physical, mechanical, rheological and tribotechnical properties, as well as in ensuring the necessary dimensional and geometric accuracy of the restored joints of parts. (Research purpose) The research purpose is in developing a typical technological process for restoring the landing surfaces of the shafts of machine mechanisms for rolling bearings by combining electromechanical processing with the application of polymer coatings. (Materials and мethods) The article presents the studies of the physical, mechanical and rheological properties of polymer materials and combined coatings on the AI-7000M breaking machine of GOTECH Testing Machines Inc. The UGN60R software package was used to process the obtained results. (Results and discussion) The article presents a mathematical model that allows us to describe the process of loading the combined coating of a worn part with the determination of its stress-strain state at the installation stage and during operation of the restored fixed joint. As a result, the load affects the change in contact pressures to a greater extent, and the volume modulus and the shear modulus of the polymer to a lesser extent. (Conclusions) A new standard technological process has been developed and tested for restoring worn-out landing surfaces of shafts for rolling bearings of transmission units of domestic and foreign tractors, cars, agricultural machinery, equipment of processing industries by combining electromechanical processing with a coating based on polymer compositions ANATERM-201 and Loctite 3472.
FAILURES OF POLYMER PARTS OF AGRICULTURAL MACHINERY
Authors:   Federal Scientific Agroengineering Center VIM, Goncharova Yuliya A. , Denisov Vyacheslav A.
Published: October 2021

Since the last century, polymer materials have been widely used in industry. They are increasingly being used in the construction of agricultural machinery. Simultaneously with the spread of polymer parts, there is a need to develop technologies for repairing agricultural machinery containing such parts. (Research purpose) The research purpose is in analyzing the failures of polymer parts of agricultural machinery and equipment. (Materials and methods) The article presents a study of cases of failures of polymer parts of agricultural machinery based on data received from the enterprise LLC "Rassvet" of the Rostov region, the production cooperative "Koelginskoe" of the Chelyabinsk region for 2019 and summary information from various suppliers of spare parts of agricultural machinery. (Results and discussion) The parts of the industrial water treatment filter, turbine water meters and the sprayer housing failed at LLC "Rassvet" during the period under review. In the production cooperative "Koelginskoe" the gear of the servo drive of the grain flow and the oil seal of the hydraulic cylinder of the tractor K-744 failed, and therefore it was necessary to replace the entire unit. It is unprofitable for dealers of agricultural machinery to supply parts in a single copy due to their low cost. (Conclusions) The nomenclature of polymer parts of agricultural machines that fail is quite diverse, and cases of their failures are not rare. In some cases, the replacement of these parts is impossible due to their absence from sale, and in other cases, it turns out to be unprofitable due to long delivery times or a large minimum order batch. In this regard, agricultural producers suffer significant losses, overpaying for a whole node instead of replacing one part.
OPTIMIZATION OF THE REPAIR AND MAINTENANCE BASE OF THE AGRO-INDUSTRIAL COMPLEX
Authors:   Federal Scientific Agroengineering Center VIM, Katayev Yuriy V. , Gerasimov Valeriy S. , Ignatov Vladimir I. , Mishina Zoya N. , Baulin Nikolay K.
Published: October 2021

The repair industry in almost all countries has entered a critical period, characterized by the need to combine and use various strategies and technologies for maintenance and repair of new equipment, as well as equipment produced many years ago. (Research purpose) The research purpose is in analyzing the state of the repair and maintenance base of the agro-industrial complex and justifying the possibilities of its modernization using intelligent technologies. (Materials and methods) Authors used methods of generalizing data from various services of agro- industrial formations of individual regions, materials of scientific and technical literature and research developments, studied data on the practical use of modern resource-saving technologies by engineering services of the agro-industrial complex of the regions when carrying out repairs and service and technological services. (Results and discussion) The lack of information about the state of the repair and maintenance base makes it difficult to determine all the criteria associated with the transition of manufacturers to a contract of the entire life cycle. Obtaining information about the state of the repair and maintenance base of the agro-industrial complex is a very important stage that contributes to the modernization of this base and attracting not only the governments, but also agricultural machinery manufacturers to modernization. (Conclusions) The technological level of the enterprises of the repair and maintenance base of agriculture has significantly decreased in recent years, and this has affected the decline in technical readiness indicators, which confirms the need to conduct research and implement in practice the main measures related to the modernization of the specified repair and maintenance base.
Probabilistic Model of the Reflectivity of Construction Materials of the Agroindustrial Complex
Authors:   Izhevsk State Agricultural Academy, Gallyamova Tat’yana R.
Published: October 2021

When developing modern lighting technologies for objects of the agro-industrial complex, the problem arises of assessing the contribution of reflected light to the normalized illumination. The reflective properties of the surfaces of materials are characterized by a reflection coeﬃcient ρ, which reaches a value of 0.7. This allows us to consider the reflective surfaces as an additional light source and the possibility of reducing energy consumption costs. (Research purpose) The research purpose is in developing a mathematical model that allows us to estimate the spectral reflection coeﬃcient ρ(λ) of materials of construction technologies of the agro-industrial complex in the ultraviolet and visible spectral regions. (Materials and methods) That the disadvantage of various models is the lack of an analytical method for calculating the reflection coeﬃcient in a wide range of wavelengths. We used a probabilistic method to overcome this disadvantage. (Results and discussion) The developed mathematical model makes it possible to estimate the reflection coeﬃcient of the rough surface of materials in a wide range of the spectrum. For concrete, the area of agreement between theory and experiment is in the wavelength range from 250 to 1000 nm. The saturation mode predicted by the theory (the independence of the reflection coeﬃcient from the wavelength) at a reflection coeﬃcient of 0.4 is consistent with the experimental values in the visible range of the spectrum for construction materials of the agro-industrial complex, in particular, gray textured concrete, gray facade paint, light wood, gray silicate brick, new plaster without whitewash. (Conclusions) In the case of normal light incidence, the developed mathematical model allows us to theoretically estimate the reflection coeﬃcient of the rough surfaces of construction technologies of the agro-industrial complex. The proposed model can be used in the development and design of a system of technological lighting of large-area premises (for example, when keeping birds on the floor), as well as for developing recommendations for reducing the energy consumption of existing lighting systems.
Mechanism of Laccase-assisted Tyrosine Grafting on Keratin using BSA as a Model Protein
Authors: Li Yu , Su Jing , Castro Tarsila G. , Cavaco-Paulo Artur
Published: October 2021

Commercial hair perming uses strong reducing agents and is harmful to
hair fiber’s quality even human health. In this study, tyrosine is
adopted as a cross-linking agent between thiols as the shape-changing of
hair involves breakage of disulfide bonds and the rearrangement of new
bonds between keratin molecules. To investigate the mechanism of the
cross-linking, bovine serum albumin (BSA) is used as a model protein.
Molecular dynamics simulations give an insight on Cys solvent
accessibility and protein stability for the wild type BSA and a designed
BSA presenting the three broken disulfide bonds. A new cross-linked
peptide, NECFLSHK-Tyrosine-Tyrosine-GACLLPK, inter- or intra- BSA
monomers is formed, whose reactive cysteine residues are Cys-101 and
Cys-176. Moreover, curling of Asian hair is conducted using tyrosine as
a perming agent by laccase-assisted reaction. The optimized operational
conditions are hair with cysteine pre-treatment (50.0 mM) followed by
grafting with 3.0 mM tyrosine. The reshaped hair performed a better
perming performance than commercial perming product before washing,
although a lower perming efficiency after washing, however without
strength loss and could be easily accomplished with a blow-drier. Hence,
this new methodology may lead to the development of a gentle and
user-friendly approach in the hair care industry.
Enhancement of chlorine on Pd catalyst for H2O2 in-situ synthesis in electro-Fenton system: Kinetics and Mechanism
Authors: Lu Linhui , Shu Qingli , Zhang Guiru , Zhang Qi , Du Ping , Zhu Xuedong
Published: October 2021

Palladium-based catalyst has been widely employed in electro-Fenton
process for in-situ generation of H2O2. However, the selectivity to H2O2
achieved so far is still far below application level. In this work, a
series of Cl-FePd/γ-Al2O3/Al catalysts were prepared by a
three-step-impregnation method, exhibiting excellent activity in H2O2
in-situ synthesis and high efficiency in phenol degradation. The
characterization results showed that the Cl could assist in increasing
the content of Pd0 and reducing the isoelectric point of catalyst,
leading to the dramatic promotion in synthesis of H2O2. Moreover,
theoretical calculation and kinetics further demonstrated that the Cl
doping could facilitate the main reaction in H2O2 synthesis, as well as
inhibit side reactions, including the dissociation of O-O bond,
hydrogenation and decomposition. Furthermore, plausible mechanism and
degradation pathways were elaborated based on ESR and GC-MS results.
These findings illustrate the value of palladium-based
Cl-FePd/γ-Al2O3/Al catalyst in its application in electro-Fenton
process.
Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signaling pathway
Authors: HU Jianqiang , Gu Wenjing , Ma Ning , Fan Xiaoye , Ci Xinxin
Published: October 2021

Background and purpose: Increasing evidence suggests that ferroptosis
plays a key role in the pathophysiology of acute kidney injury induced
by cisplatin. The Nrf2 signaling pathway regulates oxidative stress and
lipid peroxidation and positively regulates cisplatin-induced AKI
(CI-AKI). However, Nrf2 and its activator leonurine on ferroptosis after
CI-AKI remain unclear. Experimental Approach: The anti-ferroptotic
effects of Nrf2 and its activator leonurine were assessed using a mouse
model of cisplatin-induced AKI. In vitro, the potential effects of
leonurine on erastin- and RSL3-induced HK-2 human PTEC ferroptosis were
examined. Key Results: As expected, Nrf2 deletion induced
ferroptosis-related protein expression and iron accumulation in vivo,
further aggravating CI-AKI. The Nrf2 activator leonurine prevented iron
accumulation and lipid peroxidation and inhibited ferroptosis in vitro,
while these effects were abolished in siNrf2-treated cells. Moreover,
leonurine potently ameliorated cisplatin-induced renal damage, as
indicated by the assessment of SCr, BUN, KIM-1, and NGAL. Importantly,
leonurine activated the Nrf2 antioxidative signaling pathway and
prohibited changes in ferroptosis-related morphological and biochemical
indicators, such as the MDA level, SOD and GSH depletion and GPX4 and
xCT downregulation, in CI-AKI. Moreover, Nrf2 KO mice were more
susceptible to ferroptosis after CI-AKI than control mice, and the
protective effects of leonurine on AKI and ferroptosis were largely
abolished in Nrf2 KO mice. Conclusion and Implications: These data
suggest that the renal protective effects of Nrf2 and its activator
leonurine on CI-AKI are achieved at least partially by inhibiting lipid
peroxide-mediated ferroptosis and highlight the potential of leonurine
as a CI-AKI treatment.
Bilge Karasunun Apokaliptik Bir Anlatısı: İncitmebeni
Authors: Şahin Seval
Published: October 2021

Bilge Karasu’nun eserlerinde varoluş, kişinin üzerinde düşündüğü en temel problemlerinden biridir. Onun eserlerindeki düşünce ve varlık arasındaki ilişki, çok farklı anlatım teknikleri ve düzlemleri yaratmasını sağlar. Bunların arasında Göçmüş Kediler Bahçesi (1979) masalları birçok farklı anlatı türü ve anlatım teknikleri arasındaki sınırları zorlayan bir eser olması sebebiyle ayrıca incelenmeye değerdir. Göçmüş Kediler Bahçesi’nde Karasu’nun eserlerindeki varoluş ve düşünce arasındaki ilişkide doğa önemli bir yer oynar. Neredeyse tüm masallarda doğanın varlığı ile kişi hayatındaki yeri vardır. Bu ilişkinin özellikle öne çıktığı masallardan “İncitmebeni” ise hem doğanın alımlanması hem de varlık ve düşünce arasındaki ilişkiyi tartışmak açısından çarpıcı bir örnektir. Bu masalda doğa, bir manzara değil, bizzat yaşayan bir organizmadır ve bu organizmanın varlığı ile insanların varlığı arasındaki ilişki tartışmaya açılmıştır. Bu sebeple masalı ekoeleştiri açısından değerlendirmek edebiyattaki varoluş ve düşünce arasındaki ilişkide doğanın konumlanışını tartışmak açısından faydalı görünmektedir. Ayrıca masalın bir felaketin ardından hep bir felakete hazırlanan halkı ile sonunda bu felaketi beklemedikleri yerden yakalamaları sebebiyle “apokaliptik” bir anlatıdır.
Cafer Ramzi Ismailzadeh'in Şiir Yaratıcılığı
Authors: Seferova Günel
Published: October 2021

Edebiyat eleştirmeni, bilim adamı, çevirmen, şair Cafer Balamin'in oğlu İsmailzade'nin yaratıcılığının Azerbaycan edebiyatında özel bir yeri vardır. Doksan yıldan fazla bir sürede kaotik bir yaşam biçiminden geçen Cafer İsmailzade'nin yaşam tarzını ve yaratıcılığını keşfetmek, aslında 1920-1990'larda Azerbaycan'ın sosyo-politik ve edebi ortamının birçok yönünü aydınlatmak anlamına geliyor.
Cafer Ramzi İsmailzade, kariyerine genç yaşta başlasa da, 1935'ten beri (30 yaşından itibaren) 22 yıldan fazla hapis ve sürgünde geçirdiği için 1960'lara kadar onun yaratıcılığı hakkında daha fazla şey öğrenmek zordur. O, gençliğinde “Sufi” takma isim ile şiirler yazdı. Ama onları yayımlamamışdır. Onun ilk şiiri 1954 yılında "Jafar Ramzi" imzasıyla yayınlandı.
Cafer Ramzi'nin hayatı gibi yaratıcılığı da zengin ve çeşitlidir. Jafar Ramzi 12 kitabın yazarıdır. Bu kitapların biri monografi ("Yeğma Cendeği`nin şiiri". Bakü: "Bilim" yayıncılık, 1976), ikisi tezkire ("Söylenen söz yadigardır". Bakü: "Yazar", 1981; "Söylenen söz yadigardır". Bakü: "Yazar", 1987); dördü şiir kitabı ("Şiirler". Bakü: Azerneşr, 1974; "Günleri sayıyorum". Bakü: "Yazar", 1982; "Yürekten sesler". Bakü: "Yazar", 1986; "Geciken arzular". Bakü: "Yazar", 1990); ikisi sözlük ("Azerbaycan klasik edebiyatında kullanılan arap ve fars sözleri sözlüğü" (A.M.Babayev ile ortak). Bakü: "Maarif", 1966; "Azerbaycan klasik edebiyatında kullanılan arap ve fars sözleri sözlüğü" (A.M.babayevl? ortak). Bakü: "Maarif", 1981); dördü ise çeşitli halkların mizah ve fıkraları toplanmış kitaplardır ("Yabancı mizah". Bakü: Azerneşr, 1964; "Cennetin narları". Bakü: Azerneşr, 1966; "Gelin birlikte gülelim". Bakü: Azerneşr, 1970; "Dünya halklarının mizahi" (A.C?f?rova ile ortak). Bakü: Azerneşr, 1976).
Araştırmada Jafar Ramzi İsmayilzadeh'in lirik şiirleri yer aldı. Şiirler genel olarak incelendi ve çeşitli şiirlerden örnekler verildi.
J. Ramzi'nin şiirine baktığımızda lirik bir şair olarak şiirleriyle zamanın nabzını tutabildiği ve zamanla yankılanan eserler yazdığı sonucuna vardık. Şair, şiirlerini hem halk şiiri üslubunda hem de klasik üslupta yazarak, bir şair olarak entelektüel-medeni konumunu ortaya koymuş ve ilahi kelime aracılığıyla hayatın birçok gerçekliğini ortaya çıkarmayı başarmıştır.
Türk Halk Mimarisi Örneklerinden Gediz (Kütahya) Köy Odaları
Authors: Gürsoy Elif
Published: October 2021

Milli kültürümüzün önemli unsurlarından olan, köye çeşitli sebeplerle gelen yolcuların ihtiyaçlarının karşılandığı köy odaları, köy halkının sosyal ve kültürel amaçlarla bir araya geldiği sivil mimari örneklerini teşkil etmektedir. Günümüzde çoğunlukla önemini ve işlevini yitiren bu yapıların tespiti ve tanıtımının amaçlandığı çalışmada, Kütahya İli Gediz İlçesi’ne bağlı belde ve köylerde inceleme yapılmıştır. 20. yüzyılın ikinci yarısına tarihlenen Gediz’deki köy odası örneklerinin birçoğu fonksiyonlarını kaybetmiş ve ne yazık ki kaderine terk edilmiştir.
Gediz’de Türk misafirperverliğinin en iyi temsilcisi olan köy odalarını konu alan çalışmada, Güzüngülü Köyü’nde 3, Işıklar Köyü’nde 3, Yaylaköy’de 2, Polat Köyü’nde 2, Cebrail Beldesi’nde 3, Yeğinler Köyü’nde 6, Yağmurlar Köyü’nde 2, Yeşilova Köyü’nde 3 ve Aşıkpaşa Köyü’nde 1 adet olmak üzere toplam 25 adet köy odası yerinde tespit edilmiştir. Örnekler plan ve 2019 yılında çekilmiş fotoğrafları ile desteklenerek, tanıtımı yapılmıştır. Yapılar kat sayısına ve üst kat planına göre değerlendirilerek karakteristik özellikleri belirlenmeye çalışılmıştır. Tek katlı ve iki katlı örneklerin mevcut olduğu bölgede, üst katta dış sofalı ve iç sofalı uygulamalar görülmüştür.
Orhan Hançerlioğlu'nun İnsansız Şehir'inde Köylüler ve Kentliler
Authors: Demiryürek Meral
Published: October 2021

Orhan Hançerlioğlu (1916-1991) Trakya bölgesinde, Anadolu’da ve İstanbul’da çeşitli devlet memuriyetlerinde bulunmuş bir yazardır. Günümüzde çoğunlukla felsefe alanındaki kitaplarıyla tanınır. Hâlbuki roman ve hikâyelerinde yaşadığı, gözlemlediği yerleri insan, doğa ve gelenek bağlamında anlatmasıyla Türk edebiyatına önemli katkılarda bulunmuştur. Özellikle, 1946-1953 yılları arasında yayımlanan hikâyeleri, İstanbul insanının yanı sıra kentten uzakta görevli bir aydının bakış açısıyla köylüye dair ayrıntılara yer verişiyle ilgi uyandırır. Hikâyelerde köy ortamındaki kentlinin varlığına dayalı zıtlık, kırsal yerleşim kültürü algısını güçlendirici ve şaşırtıcı bir etki yaratır. Bu çalışmanın amacı, vefatının 30. yılında Orhan Hançerlioğlu’nun Türk edebiyatındaki yerini hatırlatarak İnsansız Şehir (1953) adıyla kitaplaşan hikâyelerinde 1940’lı yıllarda kentte ve köyde hayat mücadelesini sürdüren Türk insanının çevreye bağlı olarak geliştirdiği karakteristik davranış biçimlerini kurgusal yapının imkânları aracılığıyla incelemektir.
Kütahya İli Altıntaş İlçesi Halk Mimarisinden Örnekler: Köy Odaları
Authors: Acar Türkân
Published: October 2021

Köy odaları, Anadolu’da halk mimarisi içinde ele alınmaktadır. Köy kültüründe önemli bir yere sahip olan bu odalar, bazen evlerin yakınlarında, bazen köy meydanlarında bezen de cami yakınlarında yer almaktadır. Misafirperverliğin simge yapılarından biri olan odalar, ayrıca kırsalda sosyal ve kültürel hayatın vazgeçilmez öğelerinden biridir. Anadolu’daki köy odalarının menşei, “yurt tipi çadır”a dayanan Türk Evi’ndeki çekirdek birim “oda”nın mekansal özelliklerine dayandırılmaktadır. Türkler, Orta Asya’da sürdürülen bu geleneği Anadolu’ya taşımış, İslam dini ile birlikte misafire, konukseverliğe verilen büyük özeni içeren ayet ve hadislerde dikkate alınarak bu gelenek devam etmiştir. Yöre sakinleri ve ileri gelenleri tarafından konuk ağırlamak bir dini hizmet ve sosyal prestij olarak değerlendirilmiş ve oda yaptırmak-misafir ağırlamak için yarışılır hale gelinmiştir. Çalışmamızda Altıntaş ilçesine bağlı köylerde tespit edilen köy odalarının çoğunun terk edildiği ve işlevsiz oldukları tespit edilmiştir. Orta Asya’da başlayıp Anadolu’ya taşınan konukseverlik, birlik ve beraberliği simgeleyen, kültürel ve sosyal hayatın merkezi konumundaki köy odaları işlevleri ile somut olmayan kültürel mirasın somutlaştığı yapılardır. Bu yapıların bugün işlevsiz kalması bu mirasa sahip çıkamadığımızın bir kanıtıdır.
Bir Çözümleme Yöntemi Olarak Sanatta Göstergelerarasılık
Authors: Aktulum Kubilay
Published: October 2021

En az iki yazınsal metin arasındaki alışverişleri belirtmek için kullanılan metinlerarasılık kavramını yeni adlandırmalarla sanatın diğer biçimlerinde kullanabiliriz: örneğin, metinlerarasılık yanında resimlerarasılık, medyalararasılık, müziklerarasılık, sinemalararasılık, fotoğraflararasılık vd. Söz konusu adlandırmalar günümüzde yazın dışında başka alanlarda sıklıkla kullanılmaktadır. Bu adlandırmalara bağlı olarak, yenidenyazma, yenidenresmetme gibi kavramları alıntı, yansılama, öykünme, bilinçli esinlenme vb. kavramlarla, sanatın diğer biçimleri konusunda da kullanabiliriz. Böylelikle, Genette’in Palimpsestes adlı yapıtında önerdiği tiplemeyi dönüştürerek sanatın diğer alanlarında kullanmayı öneriyoruz. Örneğin, resim alanında resimlerarasılığın değişik biçimlerinden, dolayısıyla, iki ayrı gösterge dizgesi arasındaki alışverişleri belirtmek için kullanılan resimsel aşkınlık biçimleri konusunda yeni bir tiplemeden söz edebiliriz. Buna göre değişik göstergelerarasılık biçimlerinden söz edilebilir.. Bunlar yazınsal bir dizgenin başka bir göstergeler dizgesine aktarımı olabileceği gibi, tersine bir yönelimde de gerçekleşebilir. Göstergelerarasılık yazınsal metinleri olduğu kadar değişik sanatsal biçimlerin aralarındaki alışverişleri çözümlemeye dayanan bir yöntem ortaya koyma çabasıdır. Bu çalışmada bir çözümleme yöntemi olarak sanatın değişik biçimlerinde göstergelerarasılığın kullanımına ve kimi kavramlarına yönelik tanımlamalar yapılacaktır.
Yaşar Kemal'in Demirciler Çarşısı Cinayeti ve Yusufçuk Yusuf Romanlarında Hegemo
Authors: Şeker Aziz
Published: October 2021

Sosyal bilimler literatüründe son yıllarda toplumsal cinsiyet yaklaşımlarının yaygınlaşmasıyla erkeklik olgusu, sosyoloji ve kültürel antropoloji disiplinlerinin yapı taşı konularından biri haline gelmiştir. Bununla birlikte edebiyat ve edebiyat sosyolojisi içerisindeki çalışmalarda da ataerkillik, toplumsal cinsiyet eşitsizliği, eril tahakküm, erkeklik gibi kavramsallaştırmalar üzerinden analizler hız kazanmıştır. Özellikle toplumsal gerçekliği; kültürel, politik ve ekonomik koşullar etrafında işleyebilen romanların edebiyat sosyolojisi için ciddi bir inceleme nesnesi olduğu dikkate alındığında, bu kavramsallaştırmaların neden öne çıktığı anlaşılabilmektedir. Nihayetinde edebiyat, toplumsal tarihin dışında özerk bir sahaya karşılık gelmediği gibi erkeklik gerçeği de bu tarihe dışsal değildir. Çağdaş Türk edebiyatının önemli temsilcilerinden Yaşar Kemal de eserlerinde içinde bulunduğu dönemin toplumsal ve kültürel yapısını, üretim ilişkilerini kendine özgü tarzıyla okura sunar. Erkeklik olgusu ise bilhassa Çukurova bölgesi üzerinden çözümlediği sosyo-ekonomik, kültürel ve politik yapıyı, insan ilişkilerini boydan boya kesen önemli bir saha olarak karşımıza çıkmaktadır. Bu çalışmada tam da bu noktadan hareketle, onun Demirciler Çarşısı Cinayeti ve Yusufçuk Yusuf adlarıyla iki ciltten oluşan Akçasazın Ağaları eserini hegemonik erkeklik olgusu çerçevesinde tartışmaya açmaktadır.
Mensuração do capital intelectual de instituição financeira
Authors: Bagatini César Augusto , Feil Alexandre André
Published: October 2021

O capital intelectual é um ativo intangível sustentado pelo investimento em conhecimento, informação e experiência, e representa a criação de valor e vantagem competitiva para as organizações. Neste sentido, este estudo objetivou identificar, mensurar e analisar quantitativamente o capital intelectual de uma instituição financeira. A metodologia concentra-se em uma abordagem quantitativa, descritiva, estudo de caso e documental. Os resultados expressam que os modelos q de Tobin, Market-to-book ratio e Value, EVA e CIV demonstram o capital intelectual em valor absoluto e percentuais, porém não estratificam os elementos humano, relacional e estrutural que compõe o capital intelectual do Banco ABC. O VAIC expressa seu resultado mediante índice e na sua composição pode-se estratificar os capitais humanos, estruturais e relacionais o que auxilia no gerenciamento dos capitais para melhorar o nível de capital intelectual no Banco ABC. Conclui-se, portanto, que o modelo VAIC é o mais adequado, entre os modelos aplicados neste estudo, para mensurar o capital intelectual do Banco ABC e que contribui com seu gerenciamento em médio e longo prazo.
Traditional varieties and wild pear from Serbia: A link among antioxidant, antidiabetic and cytotoxic activities of fruit peel and flesh
Authors: Oaldje-Pavlovic Mariana , Alimpic-Aradski Ana , Savic Aleksandra , Jankovic Smiljana , Milutinovic Milena , Marin Petar , Duletic-Lausevic Sonja
Published: October 2021

This study was aimed at evaluating the antioxidant and antidiabetic
activities of methanolic extracts of peel, flesh and mixed peel, and flesh,
as well as the cytotoxic activity of mixed peel and flesh extracts obtained
from fruits of six traditional pear varieties (Vidovaca, Lubenicarka,
Karamanka, Jeribasma, Loncara and Takisa), one commercial variety (Williams
Bartlett) and a wild pear (Pyrus communis) from Serbia. The tested extracts
showed strong antioxidant activity regarding the prevention of ?-carotene
bleaching and high ?-glucosidase inhibition, and no significant cytotoxic
potential, with the exception of the Williams Bartlett and Pyrus communis
extracts. Overall, the most potent fruit part was shown to be the peel. The
most active variety in all of the applied antioxidant and antidiabetic
assays was Takisa, while the wild pear, P. communis, was the most effective
in inhibiting the proliferation of cancer cells. In conclusion, several
methanolic extracts of pear fruit are promising candidates for further
studies regarding the prevention and treatment of pathological conditions
associated with the effects of oxidative stress, such as diabetes and even
colorectal cancer.
The chemical composition, antimicrobial and antiradical properties of the essential oil of Achillea grandifolia aerial parts from Serbia
Authors: Drobac Milica , Kukic-Markovic Jelena , Milenkovic Marina , Niketic Marjan , Petrovic Silvana
Published: October 2021

Aromatic plants and essential oils have many applications in medicine,
pharmaceuticals, cosmetics, and the food industry. The essential oil of the
flowering aerial parts of Achillea grandifolia, obtained by
hydrodistillation, was analyzed for its constituents and investigated for
antimicrobial and radical scavenging activity. The essential oil was
characterized by a high amount of oxygenated monoterpenes (72.7%) with
1,8-cineole (29.2%) and camphor (23.4%) being the most abundant.
Sesquiterpenes were present in smaller quantities (4.8%). Antimicrobial
activity was tested against eight ATCC bacterial strains and two ATCC
strains of Candida albicans. The essential oil exhibited highly pronounced
antimicrobial activity against Micrococcus luteus with a MIC value of 3.50
?g/mL, as well as significant antimicrobial activity (<100 ?g/mL) against
Staphylococcus aureus, S. epidermidis and Bacillus subtilis. Gram-negative
bacteria Escherichia coli and Pseudomonas aeruginosa were resistant.
Achillea grandifolia essential oil exhibited concentration-dependent
antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical
with an SC50 value of 5.4 mg/mL. The TLC-DPPH assay revealed two main light
yellow spots indicating components with anti-DPPH activity, which after
isolation were identified as 1,8-cineole and camphor.
New records and noteworthy data of plants, algae and fungi in SE Europe and adjacent regions, 6
Authors: Tomovic Gordana , Sabovljevic Marko , Masic Ermin , Popovic Sladjana , Markovic Aleksandra , Trbojevic Ivana , Pantovic Jovana , Sutorý Karel , Niketic Marjan , Boycheva Petya , Ivanov Dobri , Hajrudinovic-Bogunic Alma , Begic Ante , Assyov Boris , Tamas Gabriela , Bîrsan Constantin-Ciprian , Ștefănuț Sorin
Published: October 2021

This paper presents new records and noteworthy data on the following taxa in
SE Europe and adjacent regions: cyanobacteria Anagnostidinema amphibium,
mycorrhizal fungus Tricholoma frondosae, stonewort Chara connivens, mosses
Dicranum polysetum and Ulota intermedia, and dicots Eclipta prostrata,
Paeonia daurica subsp. daurica, Ruta graveolens and Sorbus bosniaca.