bluuebunny/crossref_metadata_2025 huggingface dataset:
Calibration and Release of Magnetograms/Dopplergrams Obtained at the Mt. Wilson 150-foot Tower Telescope (MWO)
Authors: Ulrich Roger , Boyden John , Tran Tham
Published: July 2024

The Mt. Wilson Observatory archive of observations of solar disk magnetic fields, Doppler velocities and spectral line intensities is a resource for the study of the sun’s state over a period from 1967 to 2013. Instrument changes/upgrades during this time have to be taken into account in the interpretationof this record. Portions of this record have been previously released. This publication documents the data record in order to allow its independent interpretation. The archive is available through two directory trees which can be accessed at http://sha.stanford.edu/mwo/msm.html. Calibration of the observations is impacted by the solar surface convective flows which produce offsets to both the differential rotation and meridional circulation functions. The effectsof these offsets have been reduced in this and other publications by temporal averaging.
Lactate aggravates myocardial Ischemia-Reperfusion injury through SLC39A14-mediated ferroptosis
Authors: Hua Xu , Huang Xian-Xi , He Ling-Bin , Zhang Xin
Published: July 2024

Ferroptosis, a new form of iron-dependent regulated cell death, is driven by lipid peroxidation, playing a role in various pathogenic processes. Although the role of ferroptosis in myocardial ischemia-reperfusion injury (MIRI) has been intensively studied, the underlying molecular mechanisms remained largely unclear. Here, we showed that lactate participated in ferroptosis induced by hypoxia/reoxygenation in H9C2 cell. Importantly, hypoxia/reoxygenation induced apoptosis through aggravating ferroptosis by targeting NRF2/system Xc-/GPX4 axis, which reduced ROS scavenging. In addition, lactate promoted SLC39A14 expression followed by elevation of Fe2+ uptake, which generated superfluous ROS via the Fenton reaction. The excessive ROS could finally induce lipid peroxidation, thereby leading to ferroptosis characterized by cell apoptosis. Together, our findings suggest that lactate plays a crucial role as a novel regulator of ferroptosis, and reducing lactate levels might potentially offer a promising therapeutic strategy for managing myocardial ischemia-reperfusion injury.
Comparison the effect of atorvastatin and forskolin on memory after global cerebral ischemia in male rats
Authors: Bashghareh Alieh , Modarresi Peyman , Mahdavian Samaneh , Hedayatpour Azim
Published: July 2024

Objective: This study aimed to improve memory impairment after global cerebral ischemia. For this purpose, we used atorvastatin and forskolin after ischemia to improve neuronal injury and memory problems then compared the effect of these treatments to find the more effective strategy.
Methods: Adult male rats (n=70) were divided into 7groups (n=10). Group 1: control; group 2: sham; group 3: CI (global cerebral ischemia only); group 4: CI+ forskolin; group 5: CI+ atorvastatin; group 6: CI+vehicle1; group 7: CI+vehicle2. Ischemia was induced by occluding the bilateral common carotid artery. Atorvastatin and forskolin were injected intraperitoneally 4, 24, and 42 h after ischemia in group 5 and group6. Memory was evaluated with a water maze test. Data were analyzed by one-way ANOVA.
Results: The level of significance was 5% (p ≤ 0.05). Atorvastatin and forskolin treatment significantly reduced neuronal injury and improved memory in comparison with the ischemia group. Rats in the forskolin treated group had better performance in the Morris water maze test.
Conclusion: Our findings showed that forskolin is more effective compared to atorvastatin after global cerebral ischemia.
Beyond Borders: Exploring the Lived Experiences of International Migrant Women in Nigeria, a Deep Dive into Healthcare Realities and Utilization
Authors: Nwafor Juliet , Edet Rowland , Nwokoch Ezebunwa
Published: July 2024

This study explored access to and utilization of healthcare facilities among migrant women in an urban slum community in Nigeria, focusing on factors influencing healthcare-seeking behaviors and the implications for public health interventions. A qualitative case study-oriented research design was employed, involving in-depth interviews with 21 migrant women of reproductive age and 4 key informant interviews with healthcare workers in the Ayobo community of Lagos State, Nigeria. Data collection occurred from June to September 2018, and thematic analysis was used to interpret the findings. Three main themes emerged: living conditions, pattern of healthcare utilization, and factors influencing accessibility and utilization of healthcare facilities. Living conditions were characterized by housing instability, limited access to clean water and sanitation, and financial constraints. Migrant women demonstrated a preference for traditional remedies over formal healthcare due to cultural beliefs and perceived effectiveness. Recommendations from peers and family members influenced healthcare decisions. Targeted public health interventions are needed to address the multifaceted challenges faced by migrant women, including improving housing conditions, providing access to clean water and sanitation, and promoting culturally sensitive healthcare programs.
Intravenous hydrogen nanobubbles effect on cardiac physiology and quality of life: a single blind, dose-response study
Authors: Hernowo Aditya Tri , Subagjo  , Indrajani Olly , Sudarwanto Gatot , Sarwawati  , Aristyani Sherry , Sumitro Sutiman Bambang
Published: July 2024

Hydrogen nanobubbles (HNBs) showed promise for cardiovascular health and health-related quality of life (HRQoL). This study assessed intravenous HNB effects on cardiovascular parameters and HRQoL through a randomized, single-blind trial with 52 participants across six groups (control and five HNB dosages). Over 10 sessions in 5 weeks, the outcomes were measured included blood pressure, heart rate, left ventricular ejection fraction, and HRQoL via SF-36 survey. HNB administration significantly reduced systolic (144.94 to 129.88 mmHg) and diastolic (87.18 to 78.89 mmHg). Heart rate decreased slightly, and left ventricular ejection fraction increased marginally. Improvements in diastolic function, flow-mediated dilation, and HRQoL (general health, mental health, social functioning, bodily pain) were noted. Dose-dependent effects were significant at higher doses. In conclusion, HNB therapy could enhance cardiovascular function and HRQoL. Optimizing dosages and integrating comprehensive health interventions could enhance therapeutic outcomes, providing a holistic approach to managing cardiovascular health.
Measuring multidimensional poverty and child poverty in Central Sudan: Evidence from AlJezira State
Authors: Ali Gowaria Dafa Alla Abd-Elgdir
Published: July 2024

This paper presents an in-depth analysis of multidimensional poverty in central Sudan utilizing two methodologies: (MPI) and multiple overlapping deprivation analysis (MODA). The research is based on primary data collected through structured questionnaires by the Central Bureau of Statistics in 2023, covering 43 administrative units in AlJezira State and interviewing 764 randomly selected households. The study revealed that approximately one-fifth of the population in the study area experiences multidimensional poverty, with significant deprivations in education, health, and standard of living. Additionally, child poverty is notably high, with a multidimensional headcount ratio of 26% among children under five, which decreases by 5 percentage points when applying a reweighted MODA approach developed by the researchers. The practical significance of this study lies in its potential to inform targeted poverty alleviation policies and interventions, particularly in rural areas and among young children. Theoretically, this research contributes to the literature by demonstrating the value of combining MPI and MODA methodologies to capture a more comprehensive picture of poverty. The innovative aspect of this manuscript is the application of a reweighted MODA approach, which provides a nuanced understanding of child poverty and offers new insights for policy formulation. The findings underscore the urgent need for tailored strategies to address the multifaceted nature of poverty in central Sudan.
Uncontrolled Glycemic Level and its Associated Factors among Adult Diabetes Mellitus Patients Who Visited Diabetic Clinic of Tibebe Ghion Specialized Hospital, Bahir Dar, Northwest Ethiopia
Authors: Yabebal Yihealem , Genetu Abere , Wassie Gizachew Tadesse
Published: July 2024

Background: Despite the advancement of glycemic management in diabetes, achieving target glycemic control in clinical practice is very challenging. As a result, identifying the factors that influence glycemic control is crucial to improve the quality of people living with diabetes.
Objective: To assess the uncontrolled glycemic level and its associated factors among adult Diabetes mellitus patients on follow up at the Diabetic clinic of Tibebe Ghion Specialized Hospital, 2023.
Methods: An institution based cross sectional study was conducted among 229 adult diabetes mellitus patients at Tibebe Ghion Specialized Hospital from November 2023 to January 2024. The samples were selected using systematic random sampling technique. Pretested, structured, and interviewer-administered questionnaires were used to collect sociodemographic, diabetes self-care and diseases related factors parameters. HbA1c was used to assess glycemic control. Data were entered using Epidata Manager version 4.6 and analyzed using SPSS version 27. Multivariable logistic regression analysis was used to identify determinants of glycemic control, considering with a p-value of <0.05 as statically significant, with a 95% confidence interval.
Results: The mean HbA1c of the participant in the past 3 months were 8.0% [SD ± 1.8547%] and 158(69.0%) participants were having poor and or inadequate HbA1c (HbA1c ≥ 7.0). Not having access to self-monitoring blood glucose (SMBG) tools (AOR=5.48 ,95%CI 2.21-13.57), polypharmacy (AOR = 3.68, 95%CI 1.17-11.59), minimal physical activity (AOR = 3.52, 95%CI 1.17-10.53), physical inactivity (AOR = 6.55, 95%CI 2.20-19.42), poor medication adherence (AOR = 8.05, 95%CI 2.53-25.56) and body mass index (BMI) ≥ 25.0kg/m2 (AOR = 4.37, 95%CI 1.39-13.73) were factors associated with inadequate and poor glycemic control.
Conclusions:This study revealed that seven out of 10 participants had inadequate and or poor glycemic control levels. Poor glycemic control practice was associated with not having access to SMBG tools, taking poly-pharmacy, sedentary life style, poor medication adherence and BMI ≥ 25.0kg/m2. Effective and tailored interventions are needed to mitigate exposure to these risk factors to improve glycemic control and reduce uncontrolled diabetes related complications.
Metaheuristics Portfolio Optimization for Resource-Constrained Project Scheduling Problems with Milestones Payments
Authors: Phuntsho Tshewang , Gonsalves Tad
Published: July 2024

Resource constrained project scheduling problem with milestone payments (RCPSPDCF-MP) is an intractable combinatorial problem. This has prompted researchers to propose a variety of metaheuristic approaches to address the problem. Hybridizing different metaheuristics to produce synergetic effect is a complex endeavor. In this study, we propose a distributed adaptive metaheuristics selection (DAMS) that leverages distributed computing nodes of modern computing architecture to hybridize heterogeneous metaheuristics, evaluated based on Chernoff-Hoeffding upper confidence bounds (UCB1) to solve RCPSPDCF-MP. Our DAMS framework selects a tailored set of metaheuristics for each problem instance (project) from five different metaheuristics customized to solve RCPSPDCF-MP. The parameters of each metaheuristic were tuned off-line using classical particle swarm optimization (PSO). Our proposed framework is examined using project sets from the test library, Project Scheduling Library (PSPLIB). Experiments show that the hybrid of metaheuristics generated by UCB1 based DAMS framework outperform existing methods from the literature.
Timeliness of Malaria Treatment in Children Under Five Years in Uganda: An Analysis of 2016 Demographic Health Survey Data
Authors: Asiimwe John Bosco , Kadubira Eriot
Published: July 2024

Background: Malaria is ranked among the major causes of morbidity and mortality in children under 5 years of age in Uganda. Prompt and early appropriate malaria treatment can prevent progression of illness to severe stages, thereby mitigating mortality and morbidity. Therefore, this study aimed at determining the factors associated with timeliness to malaria treatment in children under five years in Uganda.
Method: This study used 2016 Uganda Demographic and Health Survey data and a total of 4,063 children under age of five years who had fever as a proxy for malaria two weeks prior to the survey were included. The median time to malaria treatment using Kaplan Meier curve were computed. A multivariable Cox regression model were fitted to establish factors associated with time to malaria treatment. Proportional hazard assumption was checked graphically and using Schoenfeld residual statistical test.
Results: Forty one percent of the children delayed to receive prompt malaria treatment beyond the recommended 24 hours. The median time to malaria treatment was 24 hours after onset of malaria symptoms. Children whose mothers made decisions jointly as a wife and a spouse on treatment were associated with faster time to malaria treatment (HR=1.11, 95%CI: 1.02-1.21) compared to when the mother made decisions alone. Children whose mothers sought treatment from community health workers were associated with faster time to malaria treatment (HR=1.17, 95%CI: 1.02-1.34) compared to those who did not. Children whose mothers/caregivers were from Western region (HR=0.84, 95%CI: 0.73-0.96) of the country were associated with delayed time to malaria treatment compared to other regions of the country. Similarly, children whose mothers frequently listened to radio were significantly associated with faster time (HR=1.11, 95%CI: 1.02-1.21) to treatment of malaria compared to those who did not listen to radio.
Conclusion: Faster time to malaria treatment was significantly associated with joint spousal health decision making, utilization of community health workers, not being in Western region of Uganda and frequency of listening to radio. Thus malaria control initiatives should focus its strategy on strengthening health interventions through introduction of programmes that can empower joint spousal decision making capabilities, facilitations and equipping of community health workers with malaria treatment, and increased frequent use of radios to relay malaria messages to communities.
Immediate Effects of Mindful Awareness in Body-oriented Therapy as an Adjunct to Medication for Opioid Use Disorder
Authors: Price Cynthia U. , Pike Kenneth C. , Treadway Anna , Palmer Julia , Merrill Joseph O.
Published: July 2024

Objective
While effective, medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health and chronic pain conditions. Interoceptive training may facilitate well-being and support medication treatment for MOUD. This study examined the pre-post effects of the mindfulness-based intervention Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to MOUD. MABT teaches interoceptive awareness skills to promote self-care and emotion regulation.
Methods
People stabilized on medication for OUD (N = 303) from 6 community clinics in Northwestern United States were recruited and randomly assigned to MABT plus MOUD or MOUD only. In a mixed-methods study, we used an intent-to-treat approach to examine the proportion of days abstinent from non-prescribed opioids, and other substance use (primary outcomes) at baseline and 3 months post-intervention. Secondary outcomes included symptoms of mental health distress; emotional regulation difficulties; pain and physical symptom indicators; interoceptive awareness and mindfulness skills. Participant experience of MABT was collected through post-intervention surveys. Changes in outcomes were assessed using linear mixed models; content analysis was used to analyze the qualitative data.
Results
Levels of overall substance use were low and did not differ between groups. Significant improvements in PTSD symptoms, interoceptive awareness, pain severity, pain activity interference, and physical symptom frequency were found for those who received MABT compared to MOUD only.
Conclusion
In this stable MOUD population, substance use outcomes were not improved, however MABT demonstrated significant positive changes across multiple health outcomes critical for improving MOUD treatment. Clinical Trials Registration: NCT04082637 on 9/3/2019
Ein Schuljahr in der Tabletklasse
Authors: Ade Larissa , Kindermann Katharina , Pohlmann-Rother Sanna
Published: July 2024

Tablets spielen im Kontext der Ausstattung von Grundschulen mit digitalen Medien eine zunehmend wichtige Rolle. Besonderes Potenzial wird ihrem Einsatz in sogenannten Tabletklassen zugeschrieben, in denen jedem Kind ein personalisiertes Endgerät zur Verfügung steht. Empirische Befunde zu solchen Klassen liegen bislang jedoch speziell für die Grundschule kaum vor. Im vorliegenden Beitrag werden ausgehend von konstituierenden Merkmalen des Lernangebots in einer Tabletklasse Ergebnisse einer Interviewstudie zur Perspektive von Grundschüler:innen berichtet. Befragt wurden Drittklässler:innen (N = 41) aus zwei Parallelklassen am Ende ihres ersten Schuljahrs in einer Tabletklasse. Alle Kinder waren mit einem personalisierten Endgerät ausgestattet, das sie in der Schule und auch bei den Hausaufgaben nutzten. Die Ergebnisse zeigen, wie die Schüler:innen die Verantwortung für die Betriebsbereitschaft und technische Funktionstüchtigkeit «ihres» Tablets erleben. Insbesondere das Schreiben mit dem Tablet-Stift bringt für die Kinder im Grundschulalter Chancen, aber auch Anforderungen mit sich. Die Drittklässler:innen beschreiben aufgrund der digitalen Vernetzung mit der Lehrkraft neue Möglichkeiten der Zusammenarbeit über die Schulmauern hinweg, die aber auch Probleme mit sich bringen. Die Ergebnisse erlauben unmittelbare Implikationen für die Weiterentwicklung des Konzepts von Tabletklassen in der Grundschule.
SPECIFICATION AND TYPES OF ASSESSMENT IN THE PROCESS OF ONLINE FOREIGN LANGUAGE LEARNING
Authors: Baranova Svitlana , Nazarenko Olena , Derkach Oleksandra
Published: July 2024

The article investigates the specification of assessment in the process of distance foreign language learning and their types. The modern world is changing every minute, presenting new challenges for all sectors of society, including the process of teaching foreign languages, which has also undergone significant changes. Over the past few years, the technology and opportunities for organizing distance learning have significantly expanded, with the number and quality of available applications, podcasts, websites, and textbooks increasing. This article explores which types of assessment in the process of learning foreign languages online can be used as well as analyzes examples based on personal experiences and interaction with students. This article focuses on highlighting different types of assessment that can be implemented in remote foreign language education. With the help of the understanding of these types, organizing distance learning has become easier, and the interactivity of classes can be advantageous in engaging students in quality foreign language learning. Importantly, each type of assessment outlined in this article is illustrated by its own examples. The article expands the understanding of the topicality of organizing properly the specification of assessments during online learning. The aim of the research is highlight the specification and the types of assessment in distance learning and show how it can work during lessons.
SEMIOTICS OF PRODUCT LABELING
Authors: Lukianova Yulia
Published: July 2024

This article examines the diversity of multimodality, that is, how different sign modes interact in texts. It highlights the importance of understanding the relationship between different modes of symbolic communication, especially in creating a connection between words and images. It examines how semiotics is closely related to visual communication and how it helps convey messages and engage the attention of an audience. The article also considers the extension of semiotics beyond language and the importance of studying sign processes in a multimodal context. It outlines various theoretical approaches and concepts that help to understand the interaction of different types of signs. Semiotics plays an important role in product labeling, where words and images are combined to convey meanings to consumers. Its importance in marketing strategies and understanding consumer behavior is also emphasized.
LINGUO-AXIOLOGICAL CHARACTERISTICS OF POLITICO-DIPLOMATIC SPEECHES
Authors: Medvid Olena , Podolkova Svitlana , Vashyst Kateryna
Published: July 2024

The article is devoted to studying the political speeches of Ukrainian presidents (the last decade) at the United Nations (UN), particularly the theoretical and methodological foundations of studying the specifics of political discourse in international communication, namely, in the politico-diplomatic aspect. This study aims to deepen the theoretical understanding of political discourse and reveal the linguistic aspects that determine the communicative nature of political speeches at the UN. In particular, the authors pay attention to the linguistic aspect of politicians' speeches in English at the UN, and conduct a detailed analysis of the axiological language tools used by the Ukrainian presidents to express their assessments and views. The use of specific lexical units that help structure and formulate political ideas, considering the international nature of diplomatic relations, is considered. Understanding the linguistic axiological features of political and diplomatic speech helps to improve communication between representatives of different countries. The study of effective ways of linguistic influence through lexical units with an evocative load can also help to reduce misunderstandings in international relations. This research has used a wide range of scientific methods, including content analysis of the English-language speeches of politicians on the background of political and diplomatic discourse using structural and semantic identification and categorization of lexical features, functional and pragmatic analysis of linguistic means of axiological nature, as well as the method of generalization and systematization to summarize and arrange the information obtained in the course of the study.
LINGUISTIC MEANS OF SPEECH MANIPULATION IN MODERN ENGLISH-LANGUAGE FOREIGN POLICY MEDIA DISCOURSE: SYNERGISTIC APPROACH
Authors: Shchyhlo Larysa , Korovai Maksym
Published: July 2024

The modern realities confronting the world are a reflection of human activity – engine of progress and development. Any system, be it linguistic, political, or otherwise, functions as a mechanism designed to achieve specific goals or to support existing circumstances. Language, in particular, is a crucial component of the political system, as throughout history and across all nations, politicians have pursued their objectives through the utilization of this universal tool. The political system is a complex mechanism in which language plays a significant role. The focal point of the article is the elucidation of linguistic means employed in the expression of speech manipulation within the modern English-language foreign policy media discourse. This analysis is conducted with reference to the three-level model of information and communication influence, encompassing micro-, meso-, and macro-levels. It has been substantiated that linguistic devices such as euphemisms present in political speeches not only impart emotional nuances to the text but also exert a significant manipulative influence on the audience of listeners and readers. It has been elucidated those linguistic strategies such as hedging and the grammatical category of modality (in our case – the conditional mood) are actively employed by political leaders, serving as tools for the accomplishment of their own intentions. Additionally, the communication hierarchy of the political agenda is addressed, which is shaped by politicians to achieve their set objectives. Furthermore, certain aspects of implementing such a political strategy have been delineated. The research findings attest that comprehending the mechanisms of linguistic manipulation contributes not only to a critical understanding of information but also to the development of media literacy. We envision the perspective for further scholarly investigations in the elaboration of a methodological framework for analyzing modern English-language foreign policy media discourse based on the principles of linguistic synergy as an interdisciplinary (and more broadly, transdisciplinary) direction within the field of philological scientific inquiry.
DENIAL OF ARMED AGGRESSION IN THE ANTI-STATE DISCOURSE OF SOCIAL MEDIA
Authors: Sydorenko Olha , Bondarenko Olena , Sushkova Olena
Published: July 2024

The article examines the linguistic means of representing the subcriminal feature "denial of the armed aggression of the Russian Federation against Ukraine" in anti-state texts on social networks. The study found that the representatives of the "denial of the armed aggression of the Russian Federation against Ukraine" are multilevel linguistic units: the negative prefix not-, in the semantic structure of which denial is part of a complex meaning; the negative particle not, used to completely deny the content of what is said; negative pronouns; and the negative predicate no. The following explicit means of realizing negation are the most productive in conflict texts: 1) general negative logical and syntactic structures with the negative particle not used in preposition to the main predicative member of a two-part sentence; 2) partially negative logical and syntactic structures with the negative particle not used in preposition to the secondary member of a two-part sentence; 3) logical and syntactic structures with the negative predicate no.
The logical operation of negation is most productively realized in the implicit form at the level of a whole sentence or microcontext and is actualized through such semantic plans as the interpretation of the armed aggression of the Russian Federation against Ukraine as a special military operation, as an internal civil conflict, as Ukrainian aggression in Donbas, the interpretation of the war as Ukraine's armed aggression, as military exercises, as a war between the United States and Russia, as a war unleashed by a third party, as well as the denial of the armed aggression of the Russian Federation against Ukraine as an unprovoked armed attack by one state against another with the aim of seizing its territory, eliminating or limiting its independence.
CONTROL INTERNO Y GESTIÓN ADMINISTRATIVA EN EL GOBIERNO AUTÓNOMO DESCENTRALIZADO MUNICIPAL DEL CANTÓN PORTOVIEJO
Authors: Vélez García Sheyla Xiomara , Morejón Santisteban Maryury Elizabeth
Published: July 2024

El presente estudio se centra en la importancia del control interno y su incidencia en la gestión administrativa del Gobierno Autónomo Descentralizado Municipal del cantón Portoviejo. El problema identificado es la percepción negativa sobre la eficacia del control interno y la gestión administrativa, lo que afecta la eficiencia operativa y la transparencia. El objetivo principal fue determinar la importancia del control interno, fundamentar teóricamente su mejora continua y diagnosticar su situación actual. Se utilizó una metodología cuantitativa, con una combinación de investigación descriptiva, bibliográfica y de campo. Las encuestas revelaron que solo el 12% de los encuestados considera adecuada la planificación administrativa, mientras que un 88% la considera inadecuada. Además, el 74% indicó que nunca se realizan evaluaciones y controles internos regulares. Las conclusiones destacan la necesidad de fortalecer los sistemas de control interno, adoptar prácticas bien estructuradas y establecer mecanismos de supervisión más frecuentes para mejorar la eficiencia operativa y la transparencia en la gestión administrativa del GAD de Portoviejo.
The complexity of tax regulations and principles of justice as determinants of taxpayer compliance: case of Indonesia
Authors: Totanan Chalarce , Jamaluddin  , Muliati  , Zahra Femilia , Ilham Pakawaru Muh.
Published: July 2024

This study aims to determine and analyze the determinants of the complexity of tax regulations and the principles of justice regarding taxpayer compliance in Indonesia. The study surveyed 148 individual taxpayers who are entrepreneurs of micro, small, and medium enterprises (MSMEs) using a Google Form. The results show that the complexity of tax regulations has a significant negative effect (–0.253) on taxpayer compliance, and the principles of justice (0.501) have a significant positive effect on taxpayer compliance. An R square shows that independent variables have a 45.5% influence on increasing taxpayer compliance. The degree of the correlation relationship between all independent variables is around 0.674. The results confirm the relationship between the complexity of tax regulations and the principle of justice and their effect on taxpayer compliance. Therefore, to increase taxpayer compliance, the government should put efforts into simplifying and explaining tax regulations. This can help reduce inadvertent errors, increase taxpayer confidence, and reduce the overall cost of complying with regulations. It is important to consider aspects of justice when designing and implementing the tax system. Efforts to increase transparency, reduce injustice, and make taxes applied proportionally can help strengthen taxpayer compliance and support the sustainability of state revenues.
Synthesis of Cadmium Oxyorthosilicate by a Sol-Gel Method
Authors: Santos Elena , Vichi Flavio
Published: July 2024

Cadmium silicates are materials of interest due to their stability and possible application as phosphors. There are three stable forms: cadmium metasilicate, CdSiO3, cadmium orthosilicate, Cd2SiO4 and cadmium oxyorthosilicate, Cd3SiO5. Of these, oxyorthosilicate is particularly challenging to obtain, leading to fewer studies. We have successfully prepared Cd3SiO5 using a sol-gel approach, employing cadmium acetate and tetraethylorthosilicate as precursors in a stoichiometric proportion of 2:1. Additionally, cetyltrimethylammonium bromide served as a template for creating a mesoporous structure. Adjusting the pH to 3 and subjecting the material to calcination at 800 °C for 6 h, we achieved the formation of cadmium oxyorthosilicate compound, identified by X-ray diffraction. Electron diffractometry and energy dispersive X-ray spectrometry confirm the phase purity. Characterization via nitrogen adsorption analysis and transmission microscopy shows aggregates of nanoparticles with a surface area of 6 m2 g-1 and a narrow pore diameter distribution centered at 5 nm.
Apresentação e Editoração
Authors: Oliveira Silva Iransé , Dutra e Silva Sandro , Cioce Sampaio Carlos Alberto
Published: July 2024

.
O Gado Zebu e a Agricultura Familiar no Brasil: o Programa de Melhoria da Qualidade Genética do Rebanho Bovino (Pró-Genética) e os Desafios para o Desenvolvimento Sustentável
Authors: Asmar Junior João , Dutra e Silva Sandro
Published: July 2024

Este artigo procurou analisar a criação e implementação do Programa de Melhoria da Qualidade Genética do Rebanho Bovino – Pró-Genética, investigando o papel dos diferentes agentes envolvidos. Nesse sentido, o papel da Associação Brasileira de Criadores de Zebu (ABCZ) na disseminação e valorização do gado zebuíno no Brasil foi destacado, bem como as suas intencionalidades e as estratégias de desenvolvimento e consolidação do programa. A pesquisa procurou ainda analisar os diferentes documentos constituídos nas últimas décadas do século XXI que favoreceu a ampliação do escopo do projeto para o melhoramento genético do gado zebu nacionalmente. Assim, essa pesquisa buscou-se demonstrar, além do processo de criação e implementação, questões que já apresentam resultados considerados exitosos bem como pontos sensíveis do programa, que ainda necessitam de aperfeiçoamento, sobretudo quando consideramos o papel periférico do agricultor familiar no planejamento e nas decisões estratégicas do Pró-Genética.
Distribuição de Casos das Principais Arboviroses em Goiás, de 2015 A 2021: Uma Perspectiva da Saúde Planetária
Authors: Moraes Filho Iel Marciano de , Tavares Giovana Galvão
Published: July 2024

O estudo visa descrever a distribuição de casos de dengue, zika e Chikungunya (DZC) no estado de Goiás, no período de 2015 a 2021, correlacionando as prevalências dessas enfermidades com as mudanças climáticas, conforme o movimento da saúde planetária. Foi utilizado dados do Boletim Epidemiológico do estado de Goiás, a pesquisa adota abordagem transversal e descritiva. Foram analisados casos confirmados e notificados por ano e local, risco regional de dengue, além de ocorrências de zika e chikungunya, tendência semanal e mortalidade. As variáveis foram processadas estatisticamente com o Excel do Microsoft Office 365. Os resultados destacam que o aumento dos vetores de DZC ocorre devido às alterações ocasionadas pelos processos de degradação ambiental, que culminaram com as mudanças climáticas, assim e de fundamental importância a atenção da saúde pública diante das doenças transmitidas por vetores especialmente nos serviços de APS, ressaltando a conexão entre suas prevalências e alterações climáticas
Análise de Indicadores de Desenvolvimento Sustentável do Município de Raposa do Maranhão
Authors: Cunha José Ricardo , Rosini Alessandro Marco , Coelho Rosemary Matias , Santos Marcio Luiz dos
Published: July 2024

Este artigo tem por objetivo analisar os indicadores de desenvolvimento sustentável e o modelo do empreendedorismo social e suas relações no desenvolvimento regional e sua conservação e uso sustentável dos serviços ecossistêmicos, no âmbito do município de Raposa do Maranhão, elevando a vocação do município nos serviços sociais e solidários integrada às riquezas naturais. O método constitui na pesquisa dos Índices de Desenvolvimento Sustentável - IDS, onde foi possível analisar evidências sociais relacionadas a uma estratégia empreendedora específica, na comunidade tradicional do município da Raposa do Maranhão. A importância social desse trabalho, diante à problematização que é trazida, dar-se pela evidência aos indicadores de desenvolvimento sustentável direcionando-os como fator de transformação social, econômico e ambiental, no combate à pobreza e promovendo melhoria econômica, diante a potencialidade de uma região voltadas para negócios sociais. Os procedimentos metodológicos compreenderam o levantamento de dados empíricos de fontes primárias e registros fotográficos. Como fonte secundária utilizou-se indicadores de desenvolvimento sustentável do município de Raposa do estado do Maranhão, e sua vocação em serviços solidários de uma economia sustentável. Como resultado alcançou-se o entendimento métrico dos indicadores sustentável do desenvolvimento regional do município de Raposa do Maranhão e a vocação ao empreendedorismo social entre a comunidade tradicional, o bioma, a territorialidade e conservação do uso e as práticas econômicas sustentáveis.
Skeletal Muscle Structural and Functional Impairments as Important Peripheral Exercise Intolerance Determinants in Pulmonary Arterial Hypertension
Authors: Malenfant Simon , Potus François , Bonnet Sébastien , Provencher Steeve
Published: July 2024

Reduced exercise tolerance stands as the foremost symptom, profoundly impacting the lives of those grappling with pulmonary arterial hypertension (PAH). This decline stems from both pulmonary and cardiac irregularities. Nonetheless, there is a burgeoning recognition that dysfunction within peripheral skeletal muscles (SKMs) significantly contributes to compromised exercise capacity. Consequently, the morphological and functional impairments of SKMs, coupled with microvascular loss, proinflammatory states, and oxidative disorders, play substantial roles in limiting exercise capacity in PAH. Regrettably, these facets have only undergone partial scrutiny. Thus, this review aims to spotlight the current body of literature concerning SKM dysfunctions in PAH and pinpoint knowledge gaps warranting further exploration to deepen our comprehension of SKM dysfunction and exercise intolerance in PAH.
INTEGRAÇÃO DA INTELIGÊNCIA ARTIFICIAL COM AS TÉCNICAS DE SEARCH ENGINE OPTIMIZATION
Authors: Camossi Gustavo , Franzo Lucas Pinto , Rodas Cecílio Merlotti
Published: July 2024

The internet has become an indispensable resource for accessing information. In this digital ecosystem, search engines play a crucial role in helping users find the most relevant content for their queries. This study aims to investigate how the application of Artificial Intelligence in content optimization can improve the relevance and accuracy of search results in Search Engine Optimization. Using an exploratory and descriptive methodology, the research explores the intersection between On-page and Off-page Search Engine Optimization techniques and AI, highlighting the application of Artificial Intelligence technologies such as natural language processing and machine learning. The results show that Artificial Intelligence has a significant impact on On-page Search Engine Optimization techniques, both in terms of the accuracy and relevance of search results. The research reveals that Artificial Intelligence can improve On-page Search Engine Optimization techniques, such as the optimization of Meta Tags and Title Tags, and On-page and Off-page Search Engine Optimization strategies. It is concluded that the integration of Artificial Intelligence into Search Engine Optimization strategies represents a significant evolution in digital marketing, offering more sophisticated and efficient methods for search engine optimization.
Applications of CRISPR in Parasitology
Authors: Tee Phoebe Yon Ern , Chu Sylvester Yee Chun , Kok Chloe Chien Yee , Foo Mun , Tan Clarence Zhen Jin , Foo Jhi Biau , Mohd Hatta Fazleen Haslinda , Tan Li Kar Stella , Hamzah Sharina
Published: July 2024

Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques
have been utilized in various research areas, including agriculture, biotechnology, and medicine.
With the use of a short sequence guide RNA and CRISPR-associated (Cas) protein, this
technique allows for robust, site-specific manipulation of the genome, aiding researchers in
making important biomedical discoveries and scientific advancements. In this review, we
explored the applications of CRISPR/Cas systems in the field of parasitology for the
identification and validation of novel functional genes, diagnosis of parasitic infections,
reduction of parasite virulence, and the disruption of disease transmission. We also discussed
how CRISPR can be used for the development of therapeutics, vaccines, and drug discovery.
Furthermore, the challenges and future perspectives of this technology are also highlighted.
Assessment of Analytical Techniques for Precise Quantification of Four Antiviral Drugs in Pharmaceutical Research and Development: A Comprehensive Review
Authors: Gupta Akhil , Pathak Shilpi
Published: July 2024

:

Precise measurement of drug concentration in pharmaceutical research is critical, especially
for anti-viral drugs like boceprevir, elvitegravir, indinavir, and saquinavir that combat viral
infections. It is well-known that analytical techniques play an imperative role in identifying and
characterizing active pharmaceutical ingredients in biological samples and drug formulations.
Moreover, precise drug assessment directly influences safety, stability, and efficacy while providing
in-depth insight into drug pharmacokinetics. Other than this, analytical techniques also aid in
identifying impurities, deteriorated products, and potential pollutants. Thus, reliable analytical
methods have become crucial for addressing challenges imposed by complex drug formulations.
The most commonly used analytical technique is UV spectrophotometry, which does not have the
high sensitivity to detect complex drug formulations. In contrast, Liquid Chromatography-Mass
Spectrometry/Mass Spectrometry (LC-MS/MS) merges two analytical techniques, chromatography
and mass spectrometry, to accurately quantify biological samples. Furthermore, Ultra-Performance
Liquid Chromatography (UPLC) provides enhanced resolution, faster analysis in short duration,
and low solvent consumption in contrast to HPLC. This comprehensive review aims to critically
assess each analytical approach's accuracy, applicability, selectivity, and limitation to provide
valuable insights for researchers and analysts. Understanding the weaknesses and strengths of
these analytical techniques will enable the researchers to select the suitable analytical method
based on their needs and requirements for quality assessment, precise drug quantification, and optimal
therapeutic efficiency. Eventually, this review intends to advance pharmaceutical research
and development, specifically for anti-viral drugs, by ensuring the effective and secure administration
of therapies.
Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System
Authors: S. Venishaa , Guleria Mridul , Kumar Prashant , Bhowmick Mithun , Bhowmick Pratibha , Ashique Sumel , Husain Iqbal , Pal Radheshyam
Published: July 2024

Drug delivery through the blood-brain barrier (BBB) is one of the key challenges in
the modern era of medicine due to the highly semipermeable characteristics of BBB that restrict
the entry of various drugs into the central nervous system (CNS) for the management of brain
disorders. Drugs can be easily incorporated into carbon nanocarriers that can cross the bloodbrain
barrier. Numerous nanocarriers have been developed, including polymeric nanoparticles,
carbon nanoparticles, lipid-based nanoparticles, etc. Among these, carbon nanostructures could
be superior due to their easier BBB penetration and strong biocompatibility. Several CDs (Carbon
dots) and CD-ligand conjugates have explored effectively penetrating the BBB, which enables
significant progress in using CD-based drug delivery systems (DDS) to manage CNS diseases.
Despite the drug delivery applications, they might also be used as a central nervous system
(CNS) drug; few of the carbon nanostructures show profound neurodegenerative activity.
Further, their impact on neuronal growth and anti- amyloid action is quite interesting. The present
study covers diverse carbon nanostructures for brain-targeted drug delivery, exploring a variety
of CNS activities. Moreover, it emphasizes recent patents on carbon nanostructures for
CNS disorders.
Glia as a New Target for Therapeutic Actions of Electroconvulsive Therapy
Authors: Hashioka Sadayuki
Published: July 2024

Although electroconvulsive therapy (ECT) has immediate and profound effects on severe
psychiatric disorders compared to pharmacotherapy, the mechanisms underlying its therapeutic effects
remain elusive. Increasing evidence indicates that glial activation is a common pathogenetic
factor in both major depression and schizophrenia, raising the question of whether ECT can inhibit
glial activation. This article summarizes the findings from both clinical and experimental studies
addressing this key question. Based on the findings, it is proposed that the suppression of glial activation
associated with neuroinflammation may be involved in the mechanism by which ECT restores
brain homeostasis and exerts its therapeutic effects.
High Optimization of Image Transmission and Object Detection Technique for Wireless Multimedia Sensor Network
Authors: Kabilan R. , R. Ravi , Gabrie J. Zahariya , Austin M. Philip
Published: July 2024

One of the most important issues in Wireless Multimedia Sensor Networks
is the energy efficiency of object detection and image transmission. In-node object
detection and tracking algorithms have been proposed in recent WMSN approaches.
However, with a little effort, the WMSN will be able to detect the presence and
absence of objects in images. For the WMSN, a new approach for the above technique
is suggested in this research. Instead of sending a whole image, this technique sends
image parts. It ensures energy saving inside the node and minimum picture content
which is transferred to the sink node. On the basis of in-node reconstructed and energy
consumption picture, it suggests that the technique is evaluated using (PSNR). In
comparison with existing state-of-the-art methodologies, simulation results
demonstrate that the suggested methodology saves 95 percent of node energy with a
received picture PSNR of 46 dB.
ANN Based Malicious IoT-BoT Traffic Detection in IoT Network
Authors: Kabilan R. , Austin M. Philip , Gabrie J. Zahariya , R. Ravi
Published: July 2024

The purpose of this study is to discover anomalies and malicious traffic in
the Internet of Things (IoT) network, which is critical for IoT security, as well as to
keep monitoring and stop undesired traffic flows in the IoT network. For this objective,
a number of researchers have developed several machine learning (ML) approach
models to limit fraudulent traffic flows in the Internet of Things network. On the other
side, due to poor feature selection, some machine learning algorithms are prone to
misclassifying mostly damaging traffic flows. Nonetheless, further study is needed on
the vital problem of how to choose helpful attributes for accurate malicious traffic
identification in the Internet of Things network. As a solution to the problem, an
Artificial Neural Network (ANN) model is proposed. The Area under Curve (AUC)
metric is used to employ the cross-entropy approach to effectively filter features using
the confusion matrix and identify effective features for the chosen Machine Learning
algorithm.
Potentials of Wild Edible Bush Onion (Afrostyrax Lepidophyllus) Plant as a Source of Essential Food and Medicinal Constituents
Authors: Oyetayo Victor Olusegun , Oyetayo Folake Lucy , Oluji Nathaniel Olawale
Published: July 2024

The Bush Onion (Afrostyrax lepidophyllus) plant is an unconventional
tropical West African plant characterized by a strong onion-like aroma. It is a member
of the Huaceae family, and its bark is used as food sauces, condiments, spices, and
flavorings due to its strong aroma. The seed is used trado-medicinally to treat venereal
diseases and gastro-enteric diseases and as a laxative and mouthwash. It also has anticancer, antioxidant, estrogenic and insecticidal properties. These effects have been
attributed to its content of phytochemical compounds such as polyphenols, flavonoids,
glycosides, saponins, alkaloids, and anthocyanins. It also contains appreciable
concentrations of certain important phytonutrients. Its potential as an affordable
nutritive source of non-synthetic constituents can be exploited as a valuable
contribution to food and medicine sources, especially in the developing world.