bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2A from ST14 Gene Variant and Decreased Matriptase Protein Expression Predict Poor Breast Cancer Survival
Authors: Kauppinen Jaana M. , Kosma Veli-Matti , Soini Ylermi , Sironen Reijo , Nissinen Minna , Nykopp Timo K. , Kärjä Vesa , Eskelinen Matti , Kataja Vesa , Mannermaa Arto
Published: March 2023

Supplementary Figure 2A from ST14 Gene Variant and Decreased Matriptase Protein Expression Predict Poor Breast Cancer Survival
Supplementary Figure 1A from A Systematic Review of p53 as a Prognostic Factor of Survival in Squamous Cell Carcinoma of the Four Main Anatomical Subsites of the Head and Neck
Authors: Tandon Sankalap , Tudur-Smith Catrin , Riley Richard D. , Boyd Mark T. , Jones Terence M.
Published: March 2023

Supplementary Figure 1A from A Systematic Review of p53 as a Prognostic Factor of Survival in Squamous Cell Carcinoma of the Four Main Anatomical Subsites of the Head and Neck
Supplementary Table 1 from Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
Authors: Middeldorp Anneke , Jagmohan-Changur Shantie , van Eijk Ronald , Tops Carli , Devilee Peter , Vasen Hans F. A. , Hes Frederik J. , Houlston Richard , Tomlinson Ian , Houwing-Duistermaat Jeanine J. , Wijnen Juul T. , Morreau Hans , van Wezel Tom
Published: March 2023

Supplementary Table 1 from Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
Supplementary figure 5 from The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis
Authors: Meneses-Echávez Jose F. , Correa-Bautista Jorge E. , González-Jiménez Emilio , Schmidt Río-Valle Jacqueline , Elkins Mark R. , Lobelo Felipe , Ramírez-Vélez Robinson
Published: March 2023

Effects of exercise on IL-10 in breast cancer survivors
Supplementary Tables and Figures from Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study
Authors: Childs Erica J. , Chaffee Kari G. , Gallinger Steven , Syngal Sapna , Schwartz Ann G. , Cote Michele L. , Bondy Melissa L. , Hruban Ralph H. , Chanock Stephen J. , Hoover Robert N. , Fuchs Charles S. , Rider David N. , Amundadottir Laufey T. , Stolzenberg-Solomon Rachael , Wolpin Brian M. , Risch Harvey A. , Goggins Michael G. , Petersen Gloria M. , Klein Alison P.
Published: March 2023

Supplementary Tables and Figures
Supplementary Figure Legend from The Relationship between Umbilical Cord Estrogens and Perinatal Characteristics
Authors: Hickey Martha , Hart Roger , Keelan Jeffrey A.
Published: March 2023

PDF file - 61KB
Supplementary Methods and Materials from Statin Use and Survival with Early-Stage Hepatocellular Carcinoma
Authors: Jeon Christie Y. , Goodman Marc T. , Cook-Wiens Galen , Sundaram Vinay
Published: March 2023

Procedure and diagnosis codes used to extract data on factors related to hepatocellular carcinoma prognosis
Supplementary Table 1 from Preoperative Serum Levels of Matrix Metalloproteinase-2 (MMP-2) and Survival of Breast Cancer among Korean Women
Authors: Song Nan , Sung Hyuna , Choi Ji-Yeob , Han Sohee , Jeon Sujee , Song Minkyo , Lee Yunhee , Park Chulbum , Park Sue K. , Lee Kyoung-Mu , Yoo Keun-Young , Noh Dong-Young , Ahn Sei-Hyun , Lee Sang-Ah , Kang Daehee
Published: March 2023

PDF file, 148KB, The previous studies on the serum levels of MMP-2 and breast cancer.
Supplemental Figures 2-4 from Association between Body Mass Index and Cancer Survival in a Pooled Analysis of 22 Clinical Trials
Authors: Greenlee Heather , Unger Joseph M. , LeBlanc Michael , Ramsey Scott , Hershman Dawn L.
Published: March 2023

Supplemental Figures 2-4
Supplementary Methods. Figures 1 - 4 , Tables 1 - 8 from Prospective Study of HPV16 Viral Load and Risk of In Situ and Invasive Squamous Cervical Cancer
Authors: Sundström Karin , Ploner Alexander , Dahlström Lisen Arnheim , Palmgren Juni , Dillner Joakim , Adami Hans-Olov , Ylitalo Nathalie , Sparén Pär
Published: March 2023

PDF file - 259K, Modeling and adjusting viral load over time
Supplementary Figure 2 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Authors: Amin Al Olama Ali , Benlloch Sara , Antoniou Antonis C. , Giles Graham G. , Severi Gianluca , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Muir Kenneth , Schleutker Johanna , Henderson Brian E. , Haiman Christopher A. , Schumacher Fredrick R. , Pashayan Nora , Pharoah Paul D.P. , Ostrander Elaine A. , Stanford Janet L. , Batra Jyotsna , Clements Judith A. , Chambers Suzanne K. , Weischer Maren , Nordestgaard Børge G. , Ingles Sue A. , Sorensen Karina D. , Orntoft Torben F. , Park Jong Y. , Cybulski Cezary , Maier Christiane , Doerk Thilo , Dickinson Joanne L. , Cannon-Albright Lisa , Brenner Hermann , Rebbeck Timothy R. , Zeigler-Johnson Charnita , Habuchi Tomonori , Thibodeau Stephen N. , Cooney Kathleen A. , Chappuis Pierre O. , Hutter Pierre , Kaneva Radka P. , Foulkes William D. , Zeegers Maurice P. , Lu Yong-Jie , Zhang Hong-Wei , Stephenson Robert , Cox Angela , Southey Melissa C. , Spurdle Amanda B. , FitzGerald Liesel , Leongamornlert Daniel , Saunders Edward , Tymrakiewicz Malgorzata , Guy Michelle , Dadaev Tokhir , Little Sarah J. , Govindasami Koveela , Sawyer Emma , Wilkinson Rosemary , Herkommer Kathleen , Hopper John L. , Lophatonanon Aritaya , Rinckleb Antje E. , Kote-Jarai Zsofia , Eeles Rosalind A. , Easton Douglas F.
Published: March 2023

Supplementary Figure 2. Absolute Risk (With no family history of prostate cancer.)
Supplementary Figure 1 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Authors: Amin Al Olama Ali , Benlloch Sara , Antoniou Antonis C. , Giles Graham G. , Severi Gianluca , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Muir Kenneth , Schleutker Johanna , Henderson Brian E. , Haiman Christopher A. , Schumacher Fredrick R. , Pashayan Nora , Pharoah Paul D.P. , Ostrander Elaine A. , Stanford Janet L. , Batra Jyotsna , Clements Judith A. , Chambers Suzanne K. , Weischer Maren , Nordestgaard Børge G. , Ingles Sue A. , Sorensen Karina D. , Orntoft Torben F. , Park Jong Y. , Cybulski Cezary , Maier Christiane , Doerk Thilo , Dickinson Joanne L. , Cannon-Albright Lisa , Brenner Hermann , Rebbeck Timothy R. , Zeigler-Johnson Charnita , Habuchi Tomonori , Thibodeau Stephen N. , Cooney Kathleen A. , Chappuis Pierre O. , Hutter Pierre , Kaneva Radka P. , Foulkes William D. , Zeegers Maurice P. , Lu Yong-Jie , Zhang Hong-Wei , Stephenson Robert , Cox Angela , Southey Melissa C. , Spurdle Amanda B. , FitzGerald Liesel , Leongamornlert Daniel , Saunders Edward , Tymrakiewicz Malgorzata , Guy Michelle , Dadaev Tokhir , Little Sarah J. , Govindasami Koveela , Sawyer Emma , Wilkinson Rosemary , Herkommer Kathleen , Hopper John L. , Lophatonanon Aritaya , Rinckleb Antje E. , Kote-Jarai Zsofia , Eeles Rosalind A. , Easton Douglas F.
Published: March 2023

Supplementary Figure 1. Absolute Risk (With family history of prostate cancer)
Supplementary data from Determinants of Breast Cancer Treatment Delay Differ for African American and White Women
Authors: McGee Sasha A. , Durham Danielle D. , Tse Chiu-Kit , Millikan Robert C.
Published: March 2023

Supplementary data for the materials and methods section.
Supplementary Materials and Methods, Supplementary Figure 1, Supplementary Tables 1 - 2 from Carnitine and Cardiac Dysfunction in Childhood Cancer Survivors Treated with Anthracyclines
Authors: Armenian Saro H. , Gelehrter Sarah K. , Vase Tabitha , Venkatramani Rajkumar , Landier Wendy , Wilson Karla D. , Herrera Claudia , Reichman Leah , Menteer John-David , Mascarenhas Leo , Freyer David R. , Venkataraman Kalyanasundaram , Bhatia Smita
Published: March 2023

PDF file - 98KB, Supplementary Figure 1: Visualization of Data Normalization. Supplementary Table 1: Description of Metabolon QC Samples. Supplementary Table 2: Metabolon QC Standards.
Figure S1 from Stool DNA Test of Methylated Syndecan-2 for the Early Detection of Colorectal Neoplasia
Authors: Niu Feng , Wen Jialing , Fu Xinhui , Li Chujun , Zhao Rongsong , Wu Shan , Yu Hao , Liu Xianglin , Zhao Xia , Liu Side , Wang Xinying , Wang Jianping , Zou Hongzhi
Published: March 2023

The schematic diagram of stool collection device.
Supplemental Materials and Methods from Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction
Authors: Busch Evan L. , Crous-Bou Marta , Prescott Jennifer , Chen Maxine M. , Downing Michael J. , Rosner Bernard A. , Mutter George L. , De Vivo Immaculata
Published: March 2023

This file provides detailed information on immunohistochemistry assay protocols as well as on the analytic handling of missing covariate data.
Supplementary Figure 1 from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk
Authors: Delahanty Ryan J. , Xiang Yong-Bing , Spurdle Amanda , Beeghly-Fadiel Alicia , Long Jirong , Thompson Deborah , Tomlinson Ian , Yu Herbert , Lambrechts Diether , Dörk Thilo , Goodman Marc T. , Zheng Ying , Salvesen Helga B. , Bao Ping-Ping , Amant Frederic , Beckmann Matthias W. , Coenegrachts Lieve , Coosemans An , Dubrowinskaja Natalia , Dunning Alison , Runnebaum Ingo B. , Easton Douglas , Ekici Arif B. , Fasching Peter A. , Halle Mari K. , Hein Alexander , Howarth Kimberly , Gorman Maggie , Kaydarova Dylyara , Krakstad Camilla , Lose Felicity , Lu Lingeng , Lurie Galina , O'Mara Tracy , Matsuno Rayna K. , Pharoah Paul , Risch Harvey , Corssen Madeleine , Trovik Jone , Turmanov Nurzhan , Wen Wanqing , Lu Wei , Cai Qiuyin , Zheng Wei , Shu Xiao-Ou
Published: March 2023

PDF file - 99K, LocusZoom plots of the top two loci using stage 1 P values.
Supplementary Data from A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus
Authors: Critchley-Thorne Rebecca J. , Davison Jon M. , Prichard Jeffrey W. , Reese Lia M. , Zhang Yi , Repa Kathleen , Li Jinhong , Diehl David L. , Jhala Nirag C. , Ginsberg Gregory G. , DeMarshall Maureen , Foxwell Tyler , Jobe Blair A. , Zaidi Ali H. , Duits Lucas C. , Bergman Jacques J.G.H.M. , Rustgi Anil , Falk Gary W.
Published: March 2023

Table S1. 15 Image Analysis Features Utilized by the Risk Classifier Table S2. Performance of Risk Classes Predicted by Test vs. Pathologic Diagnosis in Stratifying BE Patients with Prevalent HGD/EAC from Non-Progressor BE Patients. Figure S1. Representative Whole Slide Scan and Image Analysis Masks.
Supplemental Table 1. from Circulating Estrogens and Postmenopausal Ovarian Cancer Risk in the Women's Health Initiative Observational Study
Authors: Trabert Britton , Brinton Louise A. , Anderson Garnet L. , Pfeiffer Ruth M. , Falk Roni T. , Strickler Howard D. , Sliesoraitis Sarunas , Kuller Lewis H. , Gass Margery L. , Fuhrman Barbara J. , Xu Xia , Wentzensen Nicolas
Published: March 2023

Medians and inter-decile ranges of estrogens and estrogen metabolites for controls and ovarian cancer cases by subtype, nested case-control study within the Women's Health Initiative-Observational Study.
Supplementary Tables S1-S2 and Supplementary Figure S1 from Bioavailable Insulin-like Growth Factor-I Inversely Related to Weight Gain in Postmenopausal Women Regardless of Exogenous Estrogen
Authors: Jung Su Yon , Hursting Stephen D. , Guindani Michele , Vitolins Mara Z. , Paskett Electra , Chang Shine
Published: March 2023

PDF file - 70 KB, Supplemental Table S1. Median IGF concentrations by exogenous estrogen use according to weight-change group. Supplemental Table S2. Distributions of Insulin by weight change group. Supplemental Figure S1. Median IGF concentrations by weight change group according to body mass index.
Supplementary Table 1 from Body Mass Index and Risk of Gastric Cancer: A Meta-analysis of a Population with More Than Ten Million from 24 Prospective Studies
Authors: Chen Yi , Liu Lingxiao , Wang Xiaolin , Wang Jianhua , Yan Zhiping , Cheng Jieming , Gong Gaoquan , Li Guoping
Published: March 2023

PDF file - 134K, Suppl table 1. Stratified meta-analyses of body mass index and the risk of gastric cardia cancer.
Supplementary Table S3 from Racial Differences in the Association Between Preoperative Serum Cholesterol and Prostate Cancer Recurrence: Results from the SEARCH Database
Authors: Allott Emma H. , Howard Lauren E. , Aronson William J. , Terris Martha K. , Kane Christopher J. , Amling Christopher L. , Cooperberg Matthew R. , Freedland Stephen J.
Published: March 2023

Impact of race on associations between preoperative lipid levels and prostate cancer recurrence, treating non-prostate cancer deaths as a competing risk
AYA HOPE Comorbidity supplemental table from Impact of the AYA HOPE Comorbidity Index on Assessing Health Care Service Needs and Health Status among Adolescents and Young Adults with Cancer
Authors: Wu Xiao-Cheng , Prasad Pinki K. , Landry Ian , Harlan Linda C. , Parsons Helen M. , Lynch Charles F. , Smith Ashley W. , Hamilton Ann S. , Keegan Theresa H.M.
Published: March 2023

List of specific conditions in the AYA HOPE comorbidity index
Supplementary Figure S1 from A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants
Authors: Siiskonen Satu J. , Zhang Mingfeng , Li Wen-Qing , Liang Liming , Kraft Peter , Nijsten Tamar , Han Jiali , Qureshi Abrar A.
Published: March 2023

Quantile-Quantile (QQ) plot of the SCC GWAS. QQ plot of the observed vs. expected -log10(P) values for the SCC GWAS.
Supplementary Figure 4 from Putative Linkage Signals Identified for Breast Cancer in African American Families
Authors: Ochs-Balcom Heather M. , Sun Xiangqing , Chen Yanwen , Barnholtz-Sloan Jill , Erwin Deborah O. , Jandorf Lina , Sucheston-Campbell Lara , Elston Robert C.
Published: March 2023

Supplementary Figure 4. Model-free multi-point linkage by RELPAL with a maximum of 1,000,000 permutations using all relative pairs, adjusting for age and global ancestry at the individual level. Linkage P values evaluated using the alternative variance.
Supplementary Appendix 1 from Meta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk
Authors: Touvier Mathilde , Chan Doris S.M. , Lau Rosa , Aune Dagfinn , Vieira Rui , Greenwood Darren C. , Kampman Ellen , Riboli Elio , Hercberg Serge , Norat Teresa
Published: March 2023

Supplementary Appendix 1 from Meta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk
Supplementary Figures 1-3, Tables 1-4 from Added Value of a Serum Proteomic Signature in the Diagnostic Evaluation of Lung Nodules
Authors: Pecot Chad V. , Li Ming , Zhang Xueqiong J. , Rajanbabu Rama , Calitri Ciara , Bungum Aaron , Jett James R. , Putnam Joe B. , Callaway-Lane Carol , Deppen Steve , Grogan Eric L. , Carbone David P. , Worrell John A. , Moons Karel G.M. , Shyr Yu , Massion Pierre P.
Published: March 2023

PDF file - 252K
Supplementary Table 1 from HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk
Authors: Laitinen Virpi H. , Wahlfors Tiina , Saaristo Leena , Rantapero Tommi , Pelttari Liisa M. , Kilpivaara Outi , Laasanen Satu-Leena , Kallioniemi Anne , Nevanlinna Heli , Aaltonen Lauri , Vessella Robert L. , Auvinen Anssi , Visakorpi Tapio , Tammela Teuvo L.J. , Schleutker Johanna
Published: March 2023

PDF file - 84K, Different sample types included in the analyses are presented in this file.
Supplementary Figure 1 from HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk
Authors: Laitinen Virpi H. , Wahlfors Tiina , Saaristo Leena , Rantapero Tommi , Pelttari Liisa M. , Kilpivaara Outi , Laasanen Satu-Leena , Kallioniemi Anne , Nevanlinna Heli , Aaltonen Lauri , Vessella Robert L. , Auvinen Anssi , Visakorpi Tapio , Tammela Teuvo L.J. , Schleutker Johanna
Published: March 2023

PDF file - 90K, The first row shows the amino acid sequence. In the second row the predicted secondary structure is illustrated with blue (coil), red (alpha-helix) and green (beta-strand) bars. In the third row numerical value for the confidence of the prediction of secondary structure is indicated by a value ranging from 0-9. The confidence value of zero indicates the lowest possible confidence of prediction while 9 is represents the highest value of confidence. The values in the fourth row represents the relative solvent accessibility. Zero indicates a 0-9% relative solvent accessibility while the value of 9 indicates 90-100% solvent accessibility. The fifth row indicates the confidence value for the prediction of relative solvent accessibility ranging from 0-9. The confidence value of zero indicates the lowest possible confidence of prediction while 9 is represents the highest value of confidence.
Supplementary Methods and Materials 2. Search strategies of the databases used in the systematic literature review of circulating C-reactive protein and breast cancer risk in women from Circulating C-Reactive Protein and Breast Cancer Risk—Systematic Literature Review and Meta-analysis of Prospective Cohort Studies
Authors: Chan Doris S.M. , Bandera Elisa V. , Greenwood Darren C. , Norat Teresa
Published: March 2023

Search strategies for identifying relevant publications in PubMed and Web of Science
Supplementary Methods and Materials 1. PRISMA 2009 checklist of the preferred items reported in the systematic literature review of circulating C-reactive protein and breast cancer risk from Circulating C-Reactive Protein and Breast Cancer Risk—Systematic Literature Review and Meta-analysis of Prospective Cohort Studies
Authors: Chan Doris S.M. , Bandera Elisa V. , Greenwood Darren C. , Norat Teresa
Published: March 2023

PRISMA checklist of items reported in the manuscript
Supplementary Figure Legend from Viral Load of High-Risk Human Papillomaviruses as Reliable Clinical Predictor for the Presence of Cervical Lesions
Authors: Schmitt Markus , Depuydt Christophe , Benoy Ina , Bogers Johannes , Antoine Jerome , Pawlita Michael , Arbyn Marc
Published: March 2023

PDF file - 17K
Supplementary Table 2 from A Cohort Study of Metformin Exposure and Survival in Patients with Stage I–III Colorectal Cancer
Authors: Spillane Susan , Bennett Kathleen , Sharp Linda , Barron Thomas I.
Published: March 2023

PDF file - 58K, Sensitivity Analysis: Varying definition of cause of death; CRC deaths additionally classified with the inclusion of (i) all deaths where CRC was identified as a secondary cause of death ('Definition 2'), (ii) deaths due to malignant neoplasms of other/ill-defined digestive organs (ICD-10 C26), ill-defined cancer sites (ICD-10 C76.1, C80), secondary cancer sites (ICD-10 C77-C79), cancers of uncertain or unknown behaviour (ICD-10 D48.6, D48.9) and unspecified causes of death ('Definition 3').
Supplementary Table 1 from A Cohort Study of Metformin Exposure and Survival in Patients with Stage I–III Colorectal Cancer
Authors: Spillane Susan , Bennett Kathleen , Sharp Linda , Barron Thomas I.
Published: March 2023

PDF file - 47K, Characteristics of the full study cohort according to diabetes status and exposure to metformin.
Agentes e procedimentos anestésicos no tratamento das dores de origem muscular
Authors: Cavalcante Valberto de Oliveira , Rocha Roberto de Oliveira , Teixeira Manoel Jacobsen , Gonçalves Raquel Cunha
Published: March 2023

A infiltração dos pontos gatilho nas síndromes dolorosas miofasciais com anestésicos locais ou com toxina botulínica éeficaz no tratamento de várias afecções álgicas músculo-esqueléticas. Os bloqueios anestésicos da cadeia simpática são eficazes no tratamento e no preparo para o tratamento de doentes que apresentam síndrome complexa de dor regional. O implante de catéteres nos plexos nervosos, ao longo dos troncos nervosos e ou no compartimento espinal para analgesia prolongada é procedimento útil em doentes que aguardam condutas terapêuticas definitivas ou durante a execução de procedimentos de reabilitação que potencialmente agravam condições álgicas pré-existentes. As complicações decorrentes dos procedimentos anestésicos são relacionadas especialmente com a técnica empregada e natureza ou quantidade dos agentes utilizados; na maioria das vezes são passíveis de prevenção e de tratamento satisfatório. Os autores descrevem aspectos históricos, aspectos farmacocinéticos dos agentes e procedimentosanestésicos no tratamento da dor músculo-esquelética.
Dor músculo-esquelética do segmento cefálico
Authors: Siqueira José Tadeu Tesseroli de , Teixeira Manoel Jacobsen Teixeira*, Clement Haman Jacobsen
Published: March 2023

As disfunções têmporo-mandibulares, são uma das mais importantes razões músculo-esquelética de dor crânio-facial.Devido à complexidade do aparelho mastigatório, à rica inervação das estruturas que o compõem e à sua marcante participação na vida de relação dos indivíduos, anormalidades funcionais ou estruturais que o acometem podem primária ou secundariamente acarretar dor, freqüentemente, incapacitante. O histórico detalhado, os dados de semiologia clínica são mais importantes que os exames complementares para o diagnóstico. O tratamento das afecções músculo-esqueléticas dolorosas fundamenta-se na remoçãodos fatores causais, no controle sintomático da dor e nos procedimentos de reabilitação física e mental. Quando adequadamente aplicados, tais intervenções resultam em melhora da maioria dos doentes.
Lombalgia
Authors: Imamura Satiko Tomikawa , Kaziyama Helena Hideko Seguchi , Imamura Marta
Published: March 2023

A lombalgia é uma das queixas mais comuns no ser humano. Várias são as razões de sua ocorrência. Dentre elas destacam-se as de origem músculo-esquelética, incluindo especialmente, as síndromes dolorosas miofasciais. Os dados de história e de exame físico são a base do diagnóstico das etiologias e nosologias das lombalgias. A investigação diagnóstica com exames laboratoriais, eletrofisiológicos e de imagens deve ter seus achados validados com base no exame clínico e na história. O tratamento é fundamentado no controle dos sintomas e de suas repercussões físicas e psicossociais e na restauração da funcionalidade das estruturas regionais.
Tratamento cirúrgico funcional da dor
Authors: Teixeira Manoel Jacobsen , Teixeira William Gemio Jacobsen , Fonoff Erich Talamoni
Published: March 2023

Vários são os procedimentos cirúrgicos funcionais destinados ao tratamento da dor resultante de afecções músculo-esqueléticas. A descompressão de estruturas nervosastronculares ou radiculares angustiadas em decorrência de afecções inflamatórias, degenerativas, oncológicas, deformidades ósseas ou fraturas ou oncológicas do aparelholocomotor pode proporcionar alívio da dor mononeuropática. Os procedimentos neurocirúrgicos funcionais ablativos são indicados em casos de dor por nocicepção; sua indicação é restrita em doente que apresentam perspectivas de sobrevida prolongada. A simpatectomia é pouco eficaz em casos de síndrome complexa de dor regional do tipo II; as neurotomias dos ramos recorrentes posteriores das raízes espinais são úteis no tratamento da cervicalgia, dorsalgiae lombalgia de natureza miofascial; a coagulação, por radiofreqüência, dos discos intervertebrais é indicada em doentes que apresentam lombalgia decorrente de discopatias; a lesão do trato de Lissauer é indicada em casos de dor neruropática e de espasticidade; a mesencefalotomia, as talamotomias e a psicocirurgia são indicadas em casos rebeldes aos tratamentos convencionais. As cordotomias, as rizotomias e as mielopatias não são indicadas em doentes com dor músculo-esquelética. Os procedimentos endocrinológicos incluindo a hipofisectomia são úteis no tratamento da dor decorrente de metástases ósseas especialmente do carcinoma de mama, próstata ou endométrio. A estimulação elétrica do sistema nervoso central geralmente não proporcionam alívio nos doente que apresentam dor músculo-esquelética, exceto, em casos de síndrome pós-laminectomia. A infusão de fármacos analgésicos no compartimento espinal ou no compartimento ventricular é eficaz no tratamento da maioria dos casos.
Iniciação científica e a formação do estudante de Medicina
Authors: Saldiva Paulo Hilário Nascimento
Published: March 2023

O texto discute o papel da iniciação científica como instrumento de aprimoramento da educação médica. O conceito que se defende é que o método científico aprimora a capacidade de auto-instrução do estudante, desenvolvendo a sua iniciativa, a capacidade de analisar criticamente a informação e a habilidade de integrar informações. Estas qualidades são de extrema valia no processo atualização constante que o médico necessita, de forma a se manter a para do progresso científico.
O consumo de substâncias psicoativas entre pessoas idosas: um olhar complexo
Authors: Cruz Vania Dias , Santos Silvana Sidney Costa , Oliveira Michele Mandagará de , Moraes Cristiane Lima de , Oliveira Paola Camargo de
Published: March 2023

Objetivo: descrever o padrão de consumo de substâncias psicoativas entre pessoas idosas sob a ótica da complexidade. Método: qualitativo do tipo estudo de caso múltiplo, realizado com onze pessoas idosas no domicílio/serviço de saúde; os dados foram coletados através de documentos, observação assistemática e entrevista semiestruturada; foram analisados de forma geral, analítica e teórica por meio da comparação dos casos; teve como eixo teórico a complexidade, sendo aprovado pelo comitê de ética em pesquisa. Resultados: quanto ao padrão de consumo de substâncias psicoativas foram achados dois temas: encontro com a substância, que identificou pessoas idosas utilizando substâncias lícitas e ilícitas, e formas de consumo; consequências e motivações do consumo e/ou abandono das drogas. São consequências as perdas materiais/econômicas e criminalidade, e, motivações a socialização e fuga do estresse/ansiedade. Os idosos que pararam ou diminuíram o consumo aderiram à estratégia de redução de danos. Conclusão: evidenciou-se o consumo de substâncias psicoativas por pessoas idosas, verificando-se espaço para o sucesso de intervenções de saúde/enfermagem com a criação de ações/programas de abordagem específica para redução de danos.
Thomas Hobbes in Racist Context
Authors: Blau Adrian
Published: March 2023

Is it anachronistic to talk about racism in Hobbes? After all, racism is usually seen as biological: the disliked group must have innate characteristics which are inherited biologically. This is mostly said to be a modern idea. Yet biological racism can be found in medieval and early modern times, as with the Spanish doctrine of limpieza de sangre (cleanliness/purity of blood). Racism, including biological racism, was much more common in Hobbes’s England than we might think, including in texts he may have read; the language of race was hardly uncommon either. Moreover, someone can be called a racist whether or not their dislike of a group is based on characteristics of a group that are inherited biologically, I argue. Whether Hobbes was a racist remains open to debate; this paper offers evidence both for and against that proposition. But we should not reject the question of Hobbes’s racism as anachronistic.
Summer Extreme Precipitation in Southern China from the Perspective of Moisture Static Energy
Authors: Yang Mengzhou , Shi Xia , Yuan Chaoxia , Lu Xinyu , Liu Jingchan
Published: March 2023

The extreme precipitation (EP) in the early and late rainy seasons in Southern China is investigated from the perspective of moist static energy (MSE). At the synoptic time scale, the EP is accompanied by the charge–discharge paradigm of the vertically integrated MSE (〈MSE〉); the positive 〈MSE〉 anomaly reaches the peak one day before EP and decreases quickly during the event. The charge–discharge paradigm of 〈MSE〉 is dominated by the horizontal and vertical advection, respectively. However, synoptic systems responsible for the 〈MSE〉 charge in the early and late rainy seasons are different due to the different horizontal distributions of climatological MSE in the lower troposphere caused by the northward migration of solar radiation and the monsoon system. At the interannual time scale, more EP in the early (late) rainy season is associated with the higher seasonal-mean 〈MSE〉 that can be caused by the anomalous anticyclone (cyclone) in the western North Pacific induced by the SST anomalies in the tropical Indian Ocean and central North Pacific (the tropical Pacific). The multimodel ensemble mean of CMIP6 models reproduces well the observed 〈MSE〉–EP relationship in both the historical and Shared Socioeconomic Pathway 5–8.5 (SSP5–8.5) runs. Moreover, the mean state of 〈MSE〉 increases in the SSP5–8.5 compared to historical runs along with more frequent occurrence of EP events. Hence, 〈MSE〉 can serve as a useful metric for studying EP in Southern China at various time scales.
Fuzzy predictive Stanley lateral controller with adaptive prediction horizon
Authors: Abdelmoniem Ahmed , Ali Abdullah , Taher Youssef , Abdelaziz Mohamed , Maged Shady A
Published: March 2023

The challenge of trajectory tracking of autonomous vehicles (AVs) is a critical aspect that must be effectively addressed. Recent studies are concerned with maintaining the yaw stability to guarantee the customers’ comfort throughout the journey. Most of the geometrical controllers solve this task by dividing it into consecutive point stabilization problems, limiting the controllers’ ability to handle sudden trajectory changes. One research presented a predictive Stanley lateral controller that uses a discrete prediction model to mimic human behavior by anticipating the vehicle’s future states. That controller is limited in its use, as the parameters must be manually tuned for every change in the maneuver or vehicle velocity. This article presents a novel approach for trajectory tracking in autonomous vehicles, by introducing a fuzzy supervisory controller that automatically adapts to changes in the vehicle’s velocity and maneuver by estimating the prediction horizon’s length and providing different weights for each controller. The proposed method overcomes the limitations of traditional controllers that require manual tuning of parameters, making it ready for real-world experiments. This is the main contribution of the research in this paper. The suggested technique demonstrated an advantage over the Basic Stanley controller and the manually tuned predictive Stanley controller in terms of the total lateral error and the model predictive control (MPC) in terms of computational time. The performance is determined by performing various simulations on V-Rep and hardware-in-the-loop (HIL) experiments on an E-CAR golf bus. A broad selection of velocities is used to validate the behavior of the vehicle while working on different maneuvers (double lane change, hook road, S road, and curved road).
Piezoresistive damage sensing and mechanical characteristics of carbon/glass hybrid thermoplastic composites
Authors: Shonar Mohammed , Chalivendra Vijaya
Published: March 2023

A comprehensive experimental investigation is performed to understand the damage sensing capabilities of thermoplastic intra-ply carbon/glass laminated composites embedded with Carbon Nanotubes (CNTs) under quasi-static interlaminar shear and mode-I fracture loading conditions. CNTs are dispersed in thermoplastic Elium® resin using a combination of ultrasonication and shear mixing processes. This resin mix is used in a vacuum infusion process to fabricate four different intra-ply laminated composites orientations; G-0-C-90 [Carbon fibers are in the longitudinal direction], G-90-C-0 [Glass fibers are in the longitudinal direction], G-45-C-45(R) [carbon and glass fibers are at +45°, and −45° from the longitudinal direction and form a repeating layup], and G-45-C-45(A) [carbon and glass fibers are at +45°, and −45°, but with alternating directions for each lamina in the layup]. Four-circumferential probes are utilized to obtain the piezo-resistance measurements associated with damage inside the composites under shear and mode-I loadings. In the shear experimentation, the G-45-C-45(A) orientation demonstrated the largest interlaminar shear strength, at 50% greater than the G-45-C-45(R) orientation. Both G-45-C-45(A) and G-45-C-45(R) had significantly larger shear strains compared to the G-90-C-0 and G-0-C-90 orientations. However, the best resolution in shear damage sensing was seen with the G-0-C-90 composites. In the mode-I fracture experiments, the greatest fracture initiation toughness is shown with the G-0-C-90 orientation, which is 80% greater than the G-90-C-0 orientation. Compared to all orientations, the G-0-C-90 orientation also provided the most sensitive electrical response.
Deferring Difference No More: An (im)modest, relational plea from/through Karen Barad
Authors: Harris Kate Lockwood , Ashcraft Karen Lee
Published: March 2023

The field of management and organization studies (MOS) regularly invokes the relational theories of Karen Barad in sociomaterial and new materialist scholarship. Taking the increasing influence of this work as our point of departure, we witness once again the deferral of difference as organizational scholars grapple with Barad’s oeuvre but gloss the work’s feminist, queer, and decolonial impetus. As a consequence, relational scholarship in MOS circulates without its commentary on gender, race, sexuality, and related axes of inequity. This article recenters these aspects of relational approaches in three steps: (1) identifying the scholarly practices through which they disappear, (2) “re-relationalizing” relational theory in its radical roots, and (3) envisioning scholarly practices that better actualize the potential of relational theories. Our goal is to cultivate the constitutive relations of MOS such that we cease the deferral of difference, both in the study of power and in studies of “generic” organizational practice.
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Authors: Datta Rupak , Han Ling , Doyle Margaret , Allore Heather , Sanft Tara , Quagliarello Vincent , Juthani-Mehta Manisha
Published: March 2023

Background:

Older adults with advanced cancer are exposed to antibiotics but estimates of adverse drug events associated with antibiotic therapy are lacking.

Aim:

Evaluate the association of antibiotic therapy with adverse drug events in older adults with advanced cancer.

Design:

Cohort study where the exposure was the ratio of days of therapy of an oral or intravenous antibiotic per patient-day and the outcome was an adverse drug event, defined as cardiotoxicity, hepatotoxicity, nephrotoxicity, Clostridioides difficile infection, or new detection of a multidrug-resistant organism.

Setting/participants:

Patients aged ⩾65 years with solid tumors from a tertiary care center who received palliative chemotherapy ( n = 914).

Results:

Mean age was 75 ± 6.6 years, and 52% were female. Common tumors were lung (31%, n = 284) and gastrointestinal (26%, n = 234). Mean time from first course of palliative chemotherapy to index admission was 128 days. Five-hundred thirty (58%) patients were exposed to antibiotics during the index admission; of these, 27% ( n = 143) met standardized criteria for infection. Patients were commonly exposed to cephalosporins (33%, n = 298) and vancomycin (30%, n = 276). Among patients exposed to antibiotics, 35% ( n = 183/530) developed an adverse drug event. In multivariable testing, antibiotic therapy was associated with development of an adverse drug event (>0 to <1 vs 0 days of therapy/patient-day: adjusted odds ratio [aOR] = 1.9; 95% confidence interval [CI], 1.2–2.8; ⩾1 vs 0 days of therapy/patient-day: aOR = 2.1, 95% CI, 1.4–3.0).

Conclusion:

Antibiotic therapy was independently associated with adverse drug events in hospitalized older adults with advanced cancer. These findings may inform antibiotic decision-making among palliative care providers.
A generalizable strategy for crosslinkable albumin-based hydrogels and application as potential anti-tumor nanoplatform
Authors: Lv WanWan , Yang Kai , Yu Jingwen , Wu Yiqing , Zhang Mengdi , Liu Zichuan , Wang Xixuan , Zhou Jiahui , Ma Haoran , Yi Rongyuan , Chu Hui , Chen Jian
Published: March 2023

Albumin-based hydrogels have emerged as promising nanoparticle systems for the effective delivery of hydrophobic anticancer drugs. Anti-cancer drugs often cause some adverse effects, such as toxicity and rapid clearance by mononuclear phagocytic systems. Herein, a new strategy of synthesizing N-hydroxysuccinimide (NHS)-activated linker to form crosslinkable albumin-based hydrogels (CABH) is reported. The CABH favored physiochemical characteristics improvement of doxorubicin (Dox) and drug release. The CABH was constructed depending on the crosslinking reaction between NHS activated glycerol and albumin. The size of CABH was approximately 200 nm examined by dynamic light scattering (DLS) and transmission electron microscopy (TEM). It was found that the particle size and size distribution of the CABH remained stable in neutral PBS for 1 week. Dox loaded CABH would be controllably released in weak acidic environment verified by in vitro release and in vitro cell imaging. The Dox loaded hydrogel results in significant killing in the case of acidic culture medium. Our work provides a crosslinking method to formulate albumin nanoplatform and improve the size, stability, drug loading capacity and controlled release, which throws light on the potential application in drug delivery.
Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis
Authors: Li Haijun , Cui Huiling , Ren Jing , Wang Di , Zhao Rumeng , Zhu Shichao , Liu Siqing , Liu Xiaohui , Tian Shuai , Zhang Yuanyuan , Zhao Panpan , Li Peng , Thorne Rick F. , Duan Shichao
Published: March 2023

Glaucoma including primary open-angle glaucoma (POAG) results from elevations in intraocular pressure (IOP). An eye-localized renin-angiotensin system (RAS) has been implicated in IOP regulation, although its mechanism of action and contribution to glaucoma is poorly understood. Here, we detected significant increases in the levels of angiotensin II (ANGII) in aqueous humor samples from POAG patients. Moreover, we determined that the concentrations of ANGII were positively correlated with IOP, suggesting a role for elevated ANGII levels in eye pathogenesis. Functional investigations demonstrated that ANGII induces the expression of fibrosis-related genes of transformed and primary human trabecular meshwork cells (HTMCs) through the transcriptional upregulation of key fibrotic genes. Parallel experiments using a murine periocular conjunctival fornix injection model confirmed that ANGII induces the expression of fibrosis-related genes in trabecular meshwork (TM) cells in vivo along with increasing IOP. ANGII was revealed to function through increasing the levels of reactive oxygen species (ROS) via selectively upregulating NOX4, with NOX4 knockdown or inhibition with GLX351322 alleviating fibrotic changes induced by ANGII. We further show that ANGII activates Smad3, with both GLX351322 and an inhibitor of Smad3 (SIS3) decreasing the phosphorylation of Smad3 and dampening the ANGII-induced increases in fibrotic proteins. Moreover, NOX4 and Smad3 inhibitors also partially rescued the elevated IOP levels induced by ANGII. Our collective results therefore highlight ANGII as a biomarker and treatment target in POAG together with establishing a causal relationship between ANGII and up-regulation of the expression of fibrosis-related genes of TM cells via a NOX4/ROS axis in cooperation with TGFβ/Smad3 signaling.
Barriers to nurses health advocacy role
Authors: Laari Luke , Duma Sinegugu E
Published: March 2023

Background

Speaking up to safeguard patients is a crucial ethical and moral obligation for nurses, but it is also a difficult and potentially dangerous component of nursing work. Health advocacy is gaining impetus in the medical literature, despite being hampered by barriers resulting in many nurses in Ghana remaining mute when faced with advocacy-required situations. We explored situations that thwart nurses from performing their health advocacy role.

Research question

What would cause nurses to take no action when they witness situations that require them to act as health advocates for their clients or communities?

Research Design

An inductive, descriptive qualitative design was used to collect and analyse data on barriers that prevent nurses from practising their health advocacy role in Ghana. Individual one-on-one in-depth interviews were conducted using a semi-structured interview guide. The data were analysed using qualitative content analysis.

Participants and research context

Twenty-four professional nurses and midwives registered with the Nursing and Midwifery Council were recruited from three regional hospitals in Ghana. These public hospitals were chosen from the upper, middle and coastal regions.

Ethical considerations

The UKZN Ethics Review Committee in South Africa and the GHS Ethics Review Committee in Ghana both gave their approval for this study.

Findings

Intrapersonal barriers, interpersonal barriers, and structural barriers emerged as major obstacles that nurses experience when performing their health advocacy role.

Conclusions

Barriers to health advocacy have undermined nurses' ability to function as health advocates and are preventing them from utilising their health advocacy position in nursing practise. Giving nursing students positive role models in the classroom and in the clinic can help them become more effective health advocates.
The Effect of Wet Coffee Processing Plant Effluent on Physicochemical and Bacteriological Quality of Receiving Rivers Used by Local Community: Case of Aroresa District, Sidama, Ethiopia
Authors: Amare Gashaw , Dobo Beyene , Haile Ermias
Published: March 2023

Freshwater bodies such as lakes, rivers, and their biodiversity are being threatened with water pollution from industrial effluents and household sewages. The main objective of this study is to assess the effects of wet coffee processing plants effluent on the physicochemical and bacteriological properties of receiving rivers. Four rivers and 4 sampling points of the selected rivers were included in the study. Focus group discussion and interview were employed to gather primary data. The result showed that parameters of water quality for downstream of the rivers were significant, particularly in the dry season with BODs ranging from 45 ± 1 to 782.6 ± 97 g/ml, COD ranges from 71 ± 21 to 1072 ± 183 g/ml, Conductivity ranges from 75.5 ± 6.6 to 943 ± 56.3, Turbidity ranges from 7 ± 0.43 to 105 ± 6.2, TDS ranges from 62 ± 6.4 to 1059.6 ± 121 g/ml, temperature ranges from 20.1 to 33 ± 1, T. coli form ranges from 77 ± 1.1 to 493 ± 66 and E. coli ranges from 28 ± 1 to 213 ± 41 were significantly higher and DO ranges from 2.6 ± 0.15 to 6.1 ± 0.78 g/ml, NH4 ranges from 1.85 ± 0.4 to 3.3 ± 0.5 g/ml, and pH ranges from 3.6 ± 0.2 to 7.3 ± 0.45 were significantly lower. Most of the samples taken from wastewater and downstream parts of the river showed high level of water contaminants that are significantly greater than the EEPA discharge limits for surface water. Moreover, the qualitative data indicated that the community was affected by bad smell and color change on rivers, skin irritation, malarial case in human due to coffee processing plant effluents. Therefore, coffee processing plants should treat their effluents before they discharge it into the rivers. Responsible government bodies should authorize activities of coffee processing plants in line with the regulations set for environmental safety.
Navigating Health Equity Through Mobility Justice: Youth of Color Organizing for Transportation Equity in Our Backyards
Authors: Vahora Karishama I. , Dove Regina M. , Par Jessica B. , Mustefa Leyila , Saelens Brian E.
Published: March 2023

There is growing awareness that the built environment and transportation affect many aspects of individual and community well-being and health. Built environment and transportation planning and decision-making, however, rarely integrate robust engagement and input from youth, particularly racially/ethnically and economically diverse youth, despite the likelihood that such planning and decisions will affect their futures. Strategies are needed that prepare, engage, and ultimately empower youth in changing systems, processes, and programs that promote equitable mobility access and opportunity for youth now and in these futures. This article describes the development, implementation, actions, and impact of the Youth for Equitable Streets (YES) Fellowship program, through the perspective of the program participants, including the youth (the Fellows), program manager, and program evaluator, focusing on key factors for making this work youth-centered and oriented to successfully influence social change in transportation for mobility justice.
Toward a Politics of Care: Southeast Asian Refugee Organizing, Kinship, Care, and Reunion
Authors: Huỳnh James , Huỳnh Victoria , lê mads , Sy Sheila
Published: March 2023

From a critical refugee studies orientation, our article redefines care within the context of myriad forms of state violence impacting Southeast Asian post-war refugee communities. Research reveals how harm is compounded at every step of Southeast Asian refugee journeys: war, forced displacement, resettlement, family separation, inherited health conditions, and generational trauma. How do we reckon with refugee trauma without conceding to it as an unchangeable fact of our lives? What knowledge might we gain by attending to the everyday work of survival in refugee communities? To answer these questions, the authors conceptualize care through (a) abolitionist organizing, (b) queer kinship and affective labor, (c) historiographic caretaking, and (d) refugee reunion.
Thoracoscopic Left Atrial Appendage Exclusion for Atrial Fibrillation Patients Intolerant to Anticoagulation
Authors: Sharaf Omar M. , Falasa Matheus P. , Jones Todd E. , Khanna Anna Y. , Xiang Kun , George Philip , Torres Vilma , Miles William M. , Beaver Thomas M.
Published: March 2023

Objective:

Outcomes associated with isolated epicardial left atrial appendage (LAA) exclusion in atrial fibrillation (AF) patients with a contraindication or intolerance to anticoagulation are not clearly defined, especially in patients with prior stroke. This study evaluated the perioperative safety, medication use, and stroke outcomes for isolated thoracoscopic LAA exclusion for stroke prevention.

Methods:

A single-center retrospective study was performed of adults undergoing isolated thoracoscopic LAA exclusion with an epicardial exclusion device without a concomitant surgical procedure. Descriptive statistics were performed.

Results:

Twenty-five patients met the inclusion criteria. The cohort was 68% male ( n = 17) with a mean age of 76.4 ± 6.5 years, a mean preoperative CHA2DS2-VASc score of 4.2 ± 1.4, and a mean preoperative HAS-BLED score of 2.68 ± 1.03. Seventeen patients (68%) had nonparoxysmal AF. There were 11 patients with intolerance of anticoagulation due to intracranial hemorrhage (44%), 6 due to gastrointestinal bleeding (24%), and 4 due to genitourinary bleeding (16%). All procedures were performed thoracoscopically with 100% technical success—the mean LAA stump length was 5.5 ± 2.3 mm on intraoperative transesophageal echocardiography. The median hospital length of stay was 2 (interquartile range [IQR] 1, 6.5) days. The median follow-up time was 430 (IQR 125, 972) days. During follow-up, 1 patient with cerebral angiopathy had temporary neurologic deficits at an outside institution, with brain imaging showing no evidence of ischemic injury. There were no other thromboembolic events over the 38.8 postoperative patient-years examined. All patients were off anticoagulation at last follow-up.

Conclusions:

This study shows the perioperative safety, technical success, freedom from anticoagulation, and stroke outcomes of isolated thoracoscopic LAA exclusion in patients with AF at high risk for thromboembolic disease.