bluuebunny/crossref_metadata_2025 huggingface dataset:
Revision Rates for Osteogenesis Imperfecta Patients Treated with Telescopic Nails. A follow-up Study After a 7-year Experience
Authors: Sterian Alin Gabriel ,   Department of Pediatric Orthopedics, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Alin Gabriel Sterian, MD, Department of Pediatric Orthopedics, Carol Davila University of Medicine and Pharmacy,37 Dionisie Lupu, 050474, Bucharest, Romania.E-mail: drsterian@gmail.com, Ulici Alexandru ,   Department of Pediatric Orthopedics, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

Osteogenesis imperfecta (OI) is a genetically determined systemic pathology that involves a disturbance in the synthesis of type one collagen and is mainly characterized by bone brittleness and other abnormalities. The musculoskeletal system is the most affected by bone fracture after mild mechanical stress occurs. Pathologic bowing appears without trauma, and hyperlaxity is jeopardizing joint stability. Having such an abrupt debut, some patients report in-utero fractures, and treatment is very challenging since surgery has to be postponed until the children grow and become good candidates for intramedullary nailing. In this paper, we discuss the experience of “Grigore Alexandrescu” Hospital for Children in treating these patients and the results we obtained regarding the revision surgeries that we had done. Revision surgery is mandatory for OI patients, and there are multiple factors in deciding to use an implant. We looked back at the data collected for those cases where revision was not related to infection, trauma, or disengagement of the male-female system due to the overlengthening of the implant. The conclusions made are comparable to other centers worldwide with respect to lower limb surgery, and we changed the management protocol according to the problems encountered.
Climate Change and Social Campaigns
Authors: Raducu Raluca ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Soare Cristina ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Chichirez Cristina-Mihaela ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Cristina - Mihaela Chichirez, PhD Assist Department of Marketing and Medical Technology,Carol Davila University of Medicine and Pharmacy,8, Eroilor Sanitari Boulevard, 050474, Bucharest, Romania Phone: +40742814902 E-mail: chichirez.cristina@gmail.com, Roxana Purcarea Monica ,   Department of Nephrology, “Carol Davila” Clinical Nephrology Hospital, Bucharest, Romania
Published: November 2022

The impact of climate change on humanity and nature is increasingly evident. The atmosphere and oceans have warmed, leading to rising sea levels, a sharp drop in Arctic sea ice, floods, heatwaves, and fires. Calls to action are getting stronger. Concerns about climate change have become a full social movement, stimulating climate activism from the bottom up to the world, especially among young people. Campaigns are initiated by governments and international organizations, scientists and scientific institutions, organizations, groups, and people in civil society, public intellectuals and political, religious leaders, people of culture and entertainment. These campaigns generally aim to inform, raise awareness and shape public understanding about the science, problems, and policy of climate change, with the hope that, first of all, people will change their attitudes and behavior, and secondly, will mobilize to put pressure on policymakers for effective climate policies.
Promoting professional and interprofessional relationship among nurses in Iran: a participatory action research
Authors: Keikha Hossain ,   Department of Nursing, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran, Memarian Robabeh ,   Department of Nursing, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran,   Robabeh Memarian, Tarbiat Modares University, Bridge Nasr (Gisha). PO Box: 14115-331, Tehran, Iran. Phone: +982182883585; E-mail: memari_r@modares.ac.ir, Vanaki Zohreh ,   Department of Nursing, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Published: November 2022

Communication is the basis of nursing care and can have a significant effect on patient and community health. This study aimed to optimize the professional and interprofessional relationships of nurses. This participatory action research was conducted with 288 patients and 23 staff of one of the Reference Hospitals in Tehran, Iran, from 2019 to 2020. Interviews were simultaneously analyzed using the conventional content analysis method, and in the quantitative section, the communication skills checklist and a researcher-made questionnaire were used. Participants gave oral and written consent, and their confidentiality and anonymity were respected. Participants’ experiences showed that the implemented programs changed the work environment. The acquired basic concepts were improving the nurse’s responsibility and accountability, improving the quality of care and respecting the patient and the family. Quantitative data obtained before and after the implementation of change programs showed that patient satisfaction increased from 41.57±7.03 to 94.34±4.67 and patient and family training from 113.73±19.77 to 245.99±36.61. The length of hospital stay decreased from 5.52±2.47 to 3.57±2.35 days, nosocomial infections from 32.1±2.8 to 17.4±2.4 and readmission from 4.8±1.2 to 2.3±1.1. The results indicated that patients’ quality of care and safety was increased by optimizing the nurse’s professional and interprofessional relationship. Patients reported greater respect, and nurses had higher job satisfaction.
Cytomegalovirus infection after renal transplantation
Authors: Al Atbee Mohammed Younus Naji ,   Department of Nephrology, College of Medicine, University of Basrah, Basrah, Iraq,   Mohammed Younus Naji Al Atbee, Department of Nephrology, College of Medicine, University of Basrah, Basrah, Iraq. E-mail: Mohammed.naji@uobasrah.edu.iq, Tuama Hala Sami ,   Beradaiya Primary Health Care, Basrah, Iraq
Published: November 2022

Renal transplant patients show a high prevalence of cytomegalovirus (CMV) infection after the procedure. This study was conducted to assess the prevalence and factors associated with the incidence of CMV infection among renal transplant patients. A total of 100 patients were recruited in this study. The CMV load in the blood of each patient was assessed using the technique of polymerase chain reaction (PCR). The serostatus of all recipients and donors was examined preoperatively and those of the recipients again postoperatively. The association of CMV load was assessed with the following factors: age, gender, alanine aminotransferase (ALT) and serum creatinine levels, types of immunosuppressive and induction regimens, preoperative diabetes status, and serological virologic response (SVR) at 12 weeks postoperatively. Our findings showed that CMV incidence was significantly higher in middle-aged patients (62 of 66 patients, 93.9%; p=0.0001). Furthermore, about 88.2% of patients induced by anti-thymocyte globulin (ATG) showed a high viral load, significantly higher than the proportion of CMV-positive patients induced by basiliximab (p=0.001). In addition, a higher proportion of CMV-negative recipients who received the graft from CMV-positive donors and vice-versa were CMV-positive postoperatively. Administration of Valcyte 450 showed 100% efficiency in decreasing the CMV load in the patients. Among all the assessed factors, only the age of the recipients, type of induction therapy used, and the preoperative serostatus of both donors and recipients were significantly associated with the postoperative CMV incidence among the patients.
Splenic-preserving surgery in hydatid spleen: a single institutional experience
Authors: Al-Hakkak Samer Makki Mohamed ,   Department of Surgery, Jabir Ibn Hayyan Medical University, Najaf, Iraq,   Samer Makki Mohamed Al-Hakkak, Department of Surgery, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Najaf, Iraq. E-mail: sammerhakak1972@gmail.com, Muhammad Ashraf Sami ,   Department of Surgery, Jabir Ibn Hayyan Medical University, Najaf, Iraq, Mijbas Saad Ab-Razq ,   Department of Surgery, College of Medicine, Kufa University, Kufa, Iraq
Published: November 2022

Though hydatid disease affects many organs in the human body, splenic hydatid accounts for approximately 0.8-4% of all human echinococcosis cases. Up to recently, splenectomy was the preferred surgery for hydatid spleen. Since 1980, conservative options to treat such a disease have become more and more prevalent. Our study aimed to assess our experience in open splenic preservative surgery for splenic hydatid in a single institutional center. Our retrospective research included ten patients with splenic hydatid operated between August 2013 and January 2018 at our medical center. The spleen was affected alone in seven cases, the liver and spleen were affected in three cases, and one of the patients had intra-peritoneal cyst disease. The diagnosis was confirmed primarily by ultrasonography. In some instances, computed tomography and magnetic resonance imaging were required. A chest x-ray was performed to rule out pulmonary hydatid in all patients. Open surgery procedure, field isolation, cystic fluid aspiration, and injection of 1% cetrimide solution, respiration, endocystectomy, suture of cystic edges to the intracystic tube drain were performed. All surgeries had albendazole before and after the operation 15 mg/kg/day. There were no significant intra or postoperative complications, and no further surgery was required. Patients remained hospitalized for 3-5 days. No recurrence after 1-3 follow-up years. However, three patients failed to follow up within two years. Our experience with splenic hydatids prompts us to use splenic conservation surgery whenever possible instead of splenectomy.
Effect of early GnRH antagonist administration on assisted reproductive technique outcomes in normal responders
Authors: Al-Obaidi Manal ,   Reproductive Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq,   Manal Al-Obaidi, Reproductive Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq. E-mail: drmanaltaha73@gmail.com https://orcid.org/0000-0001-8722-3159
Published: November 2022

One of the main questions in assisted reproductive techniques is how to prevent premature LH surge using a variety of protocols depending on either pituitary down-regulation, in GnRH agonist protocols, or by receptors blockage, in GnRH protocols. It is possible to say that GnRH protocols are most popular nowadays. The study aimed to assess the effectiveness of early antagonist administration during days ≤6 and later antagonist administration on days >6 on assisted reproductive outcomes. Women admitted to the ART Department at the High Institute for Infertility Diagnosis and ART, Al-Nahrain University, Baghdad, Iraq were included in the study. Reproductive outcomes were evaluated in early ≤6 and late >6 antagonist administration in a total of 44 normal responders, as follows. Sandwich protocols in 14 patients that received antagonists in the first 3 days of the follicular phase and conventional flexible antagonist protocol in 30 patients. We compared the outcomes between the two groups. There were no differences between early antagonist administration ≤6 and late >6 days in the number of MII oocytes, 2PN, the number of transferred embryos, grades of the embryos, and pregnancy rates. However, there were statistically significant differences between the duration of stimulation and the total Gonadotropin dose required. There was no effect of antagonist administration on days ≤6 and >6 on controlled ovarian stimulation on assisted reproductive outcomes.
Hyperimmune yolk extract with Immunoglobulin Y basic active principle as a possible adjuvant treatment in patients who need/benefit from neurorehabilitation, with Clostridium difficile (Clostridioides difficile) enterocolitis as intercurrent comorbidity – a systematic literature review
Authors: Mandu Mihaela ,   Department of Physical and Rehabilitation Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Neuromuscular Rehabilitation Clinic Division, Emergency Teaching Hospital Bagdasar-Arseni, Bucharest, Romania,   Mihaela Mandu, Department of Physical and Rehabilitation Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Neuromuscular Rehabilitation Clinic Division, Emergency Teaching Hospital Bagdasar-Arseni, Bucharest, Romania. E-mail: mihaelamandu37@yahoo.com, Onose Gelu ,   Department of Physical and Rehabilitation Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Neuromuscular Rehabilitation Clinic Division, Emergency Teaching Hospital Bagdasar-Arseni, Bucharest, Romania
Published: November 2022

The study aims to add a new and beneficial perspective using Immunoinstant G food supplement as an adjuvant treatment. It is essential to study the bibliographic resources in the field to identify the current stage of knowledge on this topic. For this purpose, we have prepared a systematic literature review, focusing on the possibilities of improving the treatment of Clostridium difficile (Clostridioides difficile) enterocolitis in patients who need/benefit from neurorehabilitation. The systematic literature review was prepared using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We obtained a number of 6 articles that were considered in the elaboration of our systematic literature review. We identified that this field is insufficiently studied and needs additional clinical trials. Our study contributes to increasing this understanding based on the thorough theoretical and practical approach of this topic.
State of hormonal balance in adolescent girls with menstrual function disorders associated with obesity
Authors: Borshuliak Alla Volodymyrivna ,   Kamyanets-Podilsky Medical Professional College, Kamyanets-Podilsky, Ukraine, Andriiets Oksana Anatoliivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Bakun Oksana Valerianivna ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine,   Oksana Valerianivna Bakun, Obstetrics and Gynecology Department Bukovinian State Medical University, Golovna St.129, Chernivtsi, 58000, Ukraine. Phone: +380505627338; E-mail: kupchanko06@gmail.com, Andriiets Anatolii Volodymyrovich ,   Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine, Andriiets Volodymyr Vasyliovich ,   Surgery department №1, Bukovinian State Medical University, Chernivtsi, Ukraine, Sheremet Michael Ivanovicha ,   Surgery department №1, Bukovinian State Medical University, Chernivtsi, Ukraine,   Michael Ivanovich Sheremet, First Department of Surgery Bukovinian State Medical University, Golovna St.191/16, Chernivtsi, 58018, Ukraine. Phone: +38956064607; E-mail: Myhayl71@gmail.com, Nicolae Varlas Valentin ,   Surgery department №1, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: November 2022

Investigation of the mechanisms promoting the development of menstrual function disorders associated with obesity in adolescent girls is one of the most important issues of modern medicine. This study included 110 patients. 79 patients aged 12–18 with menstrual disorders associated with obesity were divided into two groups: group 1: 46 patients with apparent signs of hyperandrogenism, group 2: 33 patients without clinical manifestations of hyperandrogenism. The control group included 31 girls of the same age with a regular menstrual cycle. The complex of hormone examination of adolescent girls included determination of serum content: gonadotropic hormones (luteinizing hormone (LH) and follicle-stimulating hormone (FSH), prolactin (PRL), estradiol (E2), testosterone (T), progesterone (PR), dehydroepiandrosterone sulfate; insulin (In) – radioisotope method on a gamma counter “Narcotest” (reagents “IMMUNOTECH”, Czech Republic). We identified hyperleptinemia and leptin resistance in patients with menstrual function impairment associated with obesity. In group I, the adiponectin level exceeded the values of the control group (p<0.05). The results revealed a decrease in A/L in group I – 5.4 times compared with patients in group II (p<0.05) and 4.3 times – compared with the control group (p<0.05). The results revealed a decrease in A/L among girls in the group I with MFI associated with obesity – 4.3 times - compared with girls in the control group (p<0,05).
Romanian patients’ access to clubfoot treatment services
Authors: Duran Bianca Oana ,   Department of Public Health, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania,   Center for Health Workforce Research and Policy, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania,   Bianca Oana Duran, Department of Public Health, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania. E-mail: bianca.duran@publichealth.ro, Ungureanu Marius Ionut ,   Department of Public Health, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania,   Center for Health Workforce Research and Policy, Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
Published: November 2022

The number of clubfoot new cases in Romania is on the rise. According to orthopedic research, the Ponseti method is the elective treatment for clubfeet. This paper aims to provide an overview of the current facilitators and barriers in accessing clubfoot treatment services in Romania and to assess the impact of care-related factors on patients’ well-being. Our research shows that nationally, few orthopedic surgeons are using the Ponseti method and most of them are concentrated only in Cluj-Napoca. Moreover, gynecologists, neonatologists, and family physicians were not informed about the initial diagnosis and the current treatment of clubfoot. Primary medical care was significantly postponed in some cases. Moreover, no clubfoot organizations were mentioned by the parents included in the study, and psychological support was provided neither for the parents nor for the children. Based on the results of our study, we conclude that more efforts need to be done for the diagnosis and treatment of children with clubfeet. These include actions which are focused on raising awareness around this abnormality and more well-developed treatment guidelines.
Clinical and biochemical profile of COVID-19 patients admitted in a tertiary care hospital in Visakhapatnam, India during post unlock 2.0 – a retrospective study
Authors: Valapala Venkat Narayana Goutham ,   Department of General Medicine, Gitam Institute of Medical Sciences and Research, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India,   Venkat Narayana Goutham Valapala, Department of General Medicine, Gitam Institute Of Medical Sciences and Research, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India. E-mail: gvalapal@gitam.edu, Dasari Nikhila ,   Department of Respiratory Medicine, Gitam Institute of Medical Sciences and Research, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India, Kolli Viswa Kalyan ,   Department of Biochemistry, Gitam Institute of Medical Sciences and Research, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India, Mandapaka Murty ,   Department of General Medicine, Gitam Institute of Medical Sciences and Research, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India
Published: November 2022

There have been more than 31378143 confirmed coronavirus disease 2019 (COVID-19) cases in India. It was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Because the risk of severe COVID-19 is not consistent across all individuals, uncertainty is linked to disease development. COVID-19 results have been related to systemic inflammation as a predictor. In COVID-19, increased levels of inflammatory markers have been associated with cytokine storm, coagulopathy, and endothelial dysfunction. A significant amount of research suggests that these results have a role in the cause of death in individuals suffering from a severe form of COVID-19. We aim to show our experience of COVID-19 at GITAM Institute of Medical Sciences and Research (GIMSR), Visakhapatnam. We analyzed data on 558 patients admitted to our dedicated COVID hospital during post unlock (UL) 2.0 in India from August 2 to August 31, 2020. The mean age was 43.65 years; 69% of them were male. Using MoHFW India severity guidelines, 68.10% were mild, 18.64% were moderate, and 13.26% were severe cases. Fatigue (66.13%) was the most common complaint, followed by anosmia (63.80%), fever (57.53%), diarrhea (56.09%), shortness of breath (22.40%), and others. The most common preexisting comorbidity seen in our patients was diabetes mellitus and hypertension, respectively. Laboratory parameters revealed mean hemoglobin of 13.04±1.91 gm/dl, mean total leukocyte count of 7378.49±3229 cells/cumm, mean platelet count of 2.3±0.8 lakhs/cumm, mean erythrocyte sediment rate of 40±30 mm/hr, mean ferritin level of 335.96 ng/ml, mean D-dimer level of 794.88 ng/ml and mean CRP of 23.27 mg/l. Severity was associated with higher age, symptomatic presentation, elevated leucocytes, and elevated inflammatory markers.
Ureteral stent complications – experience on 50,000 procedures
Authors: Geavlete Petrișor ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania,   Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Petrișor Geavlete, 13 Vitan-Barzesti, Bucharest, Romania. Phone: +40 722 331 825; E-mail: geavlete@gmail.com, Georgescu Dragos ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania,   Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Mulțescu Razvan ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania, Stanescu Florin ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania, Cozma Cosmin ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania,   Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Geavlete Bogdan ,   Department of Urology, Sfantul Ioan Emergency Clinical Hospital, Bucharest, Romania,   Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

Double J stent is an essential tool in urology, being a basic part of many urological procedures. However, some issues related to their use still occur. Our study aimed to evaluate an important number of procedures, the complications of ureteral stents, and their prevention and treatment retrospectively. We evaluate 50,000 procedures performed between 1996 and 2021 on 36,688 patients. According to the stenting duration, the cases were divided into short-term (less than 6 weeks – 34,213 procedures), respectively long-term stenting (more than 6 weeks – 15,757 procedures). The indications of stenting for both groups were noted. The total number of complications was 41,369. We encountered 153 cases (0.3%) of JJ stent malposition, of which 3 cases were into the retroperitoneum, one case with parenchymal perforation and hematoma. Considering the double J migrations, we found proximal migration in 427 cases (0.9%) and distal double J migrations in 352 (0.7%) cases. The obstruction of the ureteral stent, causing inefficient drainage, was encountered in 925 cases, while irritative bladder symptoms occurred in 16,326 cases (32.7%). Hematuria was observed in 5,213 cases, in 7 cases blood transfusion being nec-essary. Urinary tract infection was diagnosed in 7,436 cases (14.8%). Stent encrustation and calcification occurred in 832 cases, while stent fragmentation was noted in 52 cases. Double J stent complications should be promptly evaluated and treated. Encrustation and stone formation in forgotten stents often lead to serious complications and should be managed with stent removal and combined endourological techniques.
Association between NMDA gene polymorphism (rs4880213) and GRIN2B blood serum levels in thyroid pathology patients
Authors: Kamyshna Iryna Ivanivna ,   Department of Medical Rehabilitation, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine,   Iryna Ivanivna Kamyshna, Department of Medical Rehabilitation, Ivan Horbachevsky Ternopil National Medical University, Majdan Voli 1, Ternopil, Ukraine, 46001. E-mail: Iryna.bilous2017@gmail.com, Pavlovych Larysa Borysivna ,   Department of Clinical Immunology, Allergology and Endocrinology, Bukovinian State Medical University, Chernivtsi, Ukraine, Kamyshnyi Aleksandr Mychailovich ,   Department of Microbiology, Virology, and Immunology, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Published: November 2022

The article discusses a new hypothesis that autoimmune diseases of the thyroid gland can lead to depression and neurological complications. It is believed that the neuronal N-methyl-D-aspartate receptor plays a significant role in depression pathophysiology and neurological and mental diseases, respectively. The study involved 153 patients with various forms of thyroid pathology. GRIN2B levels in the sera of the patients and healthy individuals were quantified using enzyme-linked immunosorbent assay with highly sensitive Human GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B) ELISA Kit. Genotyping of the glutamate ionotropic receptor NMDA type subunit 1, GRIN1 (rs4880213) gene polymorphism. The CT genotype of the NMDA gene (rs4880213) was predominant in the surveyed population. The C allele of the NMDA gene was more frequent than the T allele among patients with thyroid disease. GRIN2B levels were significantly decreased in patients with postoperative hypothyroidism 3.45 times, and in patients with AIT-induced hypothyroidism, there was a probable increase in GRIN2B levels by 1.58 times compared with controls. GRIN2B levels were significantly different in patients of different groups depending on thyroid pathology. Our study showed direct close correlation (r=0.635) between GRIN2B and anti-TPO levels (p<0.001), a significant direct close correlation (r=0.527) between GRIN2B and anti-TG levels in the blood (p<0.001). Our results allow us to consider the GRIN2B level as an important prognostic minimally invasive marker of neurological complications in endocrine pathology.
Microstructure of embolized capsule of chronic subdural hematoma
Authors: Stanishevskiy Artem , Jakovenko Andrew , Ryzhova Marina , Svistov Dmitry , Gizatullin Shamil Kh , Babichev Konstantin , Vinogradov Evgeniy , Chemodakova Ksenia
Published: November 2022

Background:

Chronic subdural hematomas (cSDHs) are frequent and potentially life-threatening neurosurgical conditions affecting, first of all, elderly. Few treatment options are available ranging from observation to removal thought large craniotomy. However, currently, there is tendency to minimize surgical aggression, especially considering poor general condition of elderly patients. Thus, one of gaining popularity method of neurointerventional treatment of cSDHs is medial meningeal artery (MMA) embolization. To date, large series of cases published describing favorable outcomes of this treatment approach. At the same time, few reports are available that describe microstructural changes in cSDH’s capsule after embolization; meanwhile, no exact effect of embolization on pathophysiology of hematoma was determined.

Case Description:

Through current paper, we present two cases of cSDH that has previously undergone embolization of MMA, after which cSDHs have been operated through minicraniotomy due to complications after artery embolization. Microstructural changes of hematoma’s capsule are described and discussed.

Conclusion:

Histological changes in embolized capsule suggest embolization of MMA as a valuable method for treatment of cSDHs.
Solitary fibrous tumor/hemangiopericytoma of the cervical spine: A systematic review of the literature with an illustrative case
Authors: Colamaria Antonio , Carbone Francesco , Sacco Matteo , Corsi Fabrizio , Leone Augusto , Parbonetti Giovanni , de Notaris Matteo , Fochi Nicola Pio , Landriscina Matteo , Coppola Giulia , de Santis Elena , Giordano Guido
Published: November 2022

Background:

In the WHO 2016 classification of central nervous system tumors, solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) were considered part of the same category given a shared mutation. Nevertheless, since the new 2021 WHO classification, the term “hemangiopericytoma” has been retired, and SFT is considered an independent pathological entity.

Methods:

We reviewed the literature following preferred reporting items for systematic reviews and meta-analyses guidelines focusing on the treatment options and prognosis of patients with cervical SFT. We also present a 68-year-old female with spinal intradural extramedullary SFT complicated by diffuse extension into paravertebral tissues and muscles.

Results:

We found 38 cervical SFT in the literature. Patients averaged 47.3 years of age and 47.4% were female. Typically, these lesions spanned two spinal levels resulting in cord compression and most frequently exhibited benign features (i.e., diagnosed as Grade I SFTs). Interestingly, two patients exhibited distant metastases and had initial pathology consistent with grade II SFT.

Conclusion:

SFT of the cervical spine is rare and its management varies according to the histological grade and the clinical behavior, generally warranting surgical excision and adjuvant radiation therapy and/or systemic chemotherapy.
Variability in wound closure technique in midline posterior lumbar fusion surgery. International survey and standardized closure technique proposal
Authors: Aguilar Oscar Josue Montes , Sida Karmen Karina Alaniz , Betancourt Leonardo Álvarez , Olvera Manuel Dufoo , Bernaldez Guillermo Ivan Ladewig , López Ramón López , Oropeza Edith Oropeza , Ornelas Héctor Alonso Tirado
Published: November 2022

Background:

Surgical wound complications represent an important risk factor, particularly in multilevel lumbar fusions. However, the literature regarding optimal wound closure techniques for these procedures is limited.

Methods:

We performed an online survey of 61 spinal surgeons from 11 countries, involving 25 different hospitals. The study included 26 neurosurgeons, 21 orthopedists, and 14 residents (Neurosurgery – 6 and orthopedics 8). The survey contained 17 questions on demographic information, closure techniques, and the use of drainage in posterior lumbar fusion surgery. We then developed a “consensus technique.”

Results:

The proposed standardized closure techniques included: (1) using subfascial gravity drainage (i.e., without suction) with drain removal for <50 ml/day or a maximum duration of 48 h, (2) paraspinal muscle, fascia, and supraspinous ligament closure using interrupted-X stitches 0 or 1 Vicryl or other longer-lasting resorbable suture (i.e., polydioxanone suture), (3) closure of subcutaneous tissue with interrupted inverted Vicryl 2-0 sutures in two planes for subcutaneous tissue greater >25 mm in depth, and (4) skin closure with simple interrupted nylon 3-0 sutures.

Conclusion:

There is great variability between closure techniques utilized for multilevel posterior lumbar fusion surgery. Here, we have described various standardized/evidence-based proven techniques for the closure of these wounds.
Intramedullary schwannoma – A case report
Authors: Shahab Fawwaz Bin , Khan Saad Akhtar
Published: November 2022

Background:

Schwannomas are benign but clinically progressive tumors. Mostly, they present as intradural extramedullary lesions. They are quite rare in the intramedullary (IM) region. We report a case of IM schwannoma.

Case Description:

A 52-year-old gentleman presented with a history of gait instability and numbness in bilateral lower limbs. He had clinical signs of myelopathy. His magnetic resonance imaging (MRI) dorsal spine was done that showed an intradural IM lesion at the level of D11, with one differential of ependymoma. Near total resection of lesion was done and histopathology reported it schwannoma.

Conclusion:

Preoperative radiologic assessment for IM spinal lesions is difficult and high degree of suspicion should be present when approaching a patient with somatic pain and IM lesion on MRI, keeping in mind one differential of IM schwannoma.
Yakut heroic epos Olonkho in the context of comparative study
Authors: Иванов В.Н.
Published: November 2022

В статье ставится вопрос о необходимости проведения сравнительного изучения якутского героического эпоса олонхо, имеющего глубокие тюркские корни, в условиях развития современной эпосоведческой науки. Олонхо – Шедевр Устного и Нематериального Наследия Человечества, и это предопределило огромный ин- терес к эпосу, его происхождению и бытованию в иноязычной среде Северо-Востока Азии. Использование материалов эпоса обогатило теоретические положения отечественных эпосоведов. В настоящее время начи- нается новый этап сравнительного изучения олонхо, который обещает дать новые аргументы для научного решения вопросов эпического наследия не только самого якутского этноса, но и всех тюркских народов. В статье отмечены основополагающие теоретические положения известных отечественных эпосове- дов В. М. Жирмунского, Е. М. Мелетинского по вопросам сравнительного изучения эпосов. Из второй вол- ны отечественных эпосоведов наибольший интерес представляют исследования Б. Н. Путилова, которые написаны на основе обобщения данных об эпическом наследии многих народов и автор которых достиг почти адекватного понимания природы эпического творчества и внес неоценимый вклад в историко-гене- тическое и типологическое изучение эпосов. Вопросы генетической общности, языкового и этнического родства хорошо прослеживаются в работах С. Ю. Неклюдова о героическом эпосе кочевников Монголии, основные положения которых выводят автора на проблему общности эпосов тюрко-монгольских народов. Одним из первых конкретному сравнительно-историческому изучению эпосов тюрко-монгольских, в т. ч. якутского, народов посвятил свои исследования крупный якутский эпосовед И. В. Пухов, оставивший по- сле себя образцы сравнительного историко-генетического изучения якутского олонхо. В целом же новый этап сравнительного изучения героического эпоса якутов имеет в своем активе серьезный задел теорети- ческого и конкретно исследовательского характера. В статье обоснована необходимость и целесообразность новых исследований в области сравнитель- ного изучения якутского героического эпоса, с учетом теоретических достижений современного эпосо- ведения. Этому способствуют многочисленные публикации памятников якутской эпической культуры, которые свидетельствуют об удивительно богатом жанровом содержании олонхо. Конечно же, должен быть принят во внимание новый статус олонхо, как Шедевра Устного и Нематериального Наследия Че- ловечества, благодаря чему началась новая жизнь якутского олонхо в мировом эпическом пространстве.
Epic genre basis of poems of the early twentieth century (based on research materials of I. V. Pukhov)
Authors: Сивцева-Максимова П.В.
Published: November 2022

Представлен анализ работы И. В. Пухова (1904-1979) «От фольклора к литературе», где доказывается фольклорная основа поэм А. Е. Кулаковского и П. А. Ойунского. Раскрывается самобытная авторская концепция в анализах динамической связи мифов и преданий с образами якутских поэм. Существенное значение творчества Кулаковского подчеркивается признанием авторского стиля, что раскрывается в трех основных исследовательских ракурсах его произведений (фольклорной формы, структурных компонентов стиха, поэмного образа). Фактически он называет его основоположником якутской литературы и доказы- вает влияние его поэзии на последующие поколения. На этом постулате строится анализ драматической поэмы «Красный шаман». Актуальным в представленных исследованиях является убедительное доказа- тельство Пуховым своеобразия мифологических и фольклорных образов, раскрытие идеи и философских иносказаний в монологах и репликах персонажей П. А. Ойунского. Исследователь делает новаторские выводы относительно образной системы поэмы, приемов введения, наделения конкретными функциями и подтекстами частных эпизодов преданий. Резюмируется, что положительное отношение Пухова к слож- ным произведениям якутской литературы основано на исключительном знании фольклора и культуры. Он подчеркивает в композициях поэм мотивы олонхо, в системе образов – мифологические истоки; в худо- жественной идее – реалистические тенденции раскрытия темы. В этом заключаются его глубокие знания фольклора и особая методология исследователя произведений художественной литературы.
Brønsted base-catalyzed assembly of sulfochromeno [4,3-b] pyrrolidines via tandem [3+2] cycloaddition-SuFEx click reaction of ethenesulfonyl fluorides and azomethine ylides
Authors: Zhang Fang , Zhang Qichao , Liu Jichang , Dai Bin , He Lin
Published: November 2022

The synthesis of sulfochromeno [4,3-b] pyrrolidines is described. Under the catalysis of 20 mol% Brønsted base and using 4Å molecular sieves as HF scavenger, imines derived from salicylaldehydes and diethyl aminomalonate react with ethenesulfonyl fluorides through a tandem [3+2] cyclization-SuFEx click reaction to produce sulfochromeno [4,3-b] pyrrolidines in high yields.
Atomic scale mechanism of platinum catalyst restructuring under a pressure of reactant gas
Authors: Sumaria Vaidish , Nguyen Luan , Tao Franklin (Feng) , Sautet Philippe
Published: November 2022

Heterogeneous catalysis is key for chemical transformations. Understanding how catalyst active sites dynamically evolve at the atomic scale under reaction conditions is a prerequisite for accurate determination of catalytic mechanisms and predictably developing catalysts. We combine in-situ time-dependent observation and machine learning-accelerated first-principle atomistic simulations to uncover the mechanism of restructuring of Pt catalysts under a pressure of carbon monoxide (CO). We show that a high CO coverage at a Pt step edge triggers the formation of atomic protrusions of low-coordination Pt atoms, which then detach from the step edge to create subnano-islands on the terraces, where undercoordinated sites are stabilized by the CO adsorbates. The fast and accurate machine learning potential is key to enable the exploration of ten of thousands of configurations for the CO covered restructuring catalyst. These studies open an avenue to achieve atom-scale understanding of structural dynamics of more complex metal nanoparticle catalysts under reaction.
LinChemIn: SynGraph. A data model and a toolkit to analyze and compare synthetic routes
Authors: Pasquini Marta , Stenta Marco
Published: November 2022

Background. The increasing amount of chemical reaction data makes traditional ways to navigate its corpus less effective, while the demand for novel approaches and instruments is rising. Recent data science and machine learning techniques support the development of new ways to extract value from the available reaction data. On the one side, Computer-Aided Synthesis Planning tools can predict synthetic routes in a model-driven approach; on the other side, experimental routes can be extracted from the Network of Organic Chemistry, in which reaction data are linked in a network. In this context, the need to combine, compare and analyze synthetic routes generated by different sources arises naturally. Results. Here we present LinChemIn, a python toolkit that allows chemoinformatics operations on synthetic routes and reaction networks. Wrapping some third-party packages for handling graph arithmetic and chemoinformatics and implementing new data models and functionalities, LinChemIn allows the interconversion between data formats and data models and enables route-level analysis and operations, including route comparison and descriptors calculation. Object-Oriented Design principles inspire the software architecture, and the modules are structured to maximize code reusability and support code testing and refactoring. The code structure should facilitate external contributions, thus encouraging open and collaborative software development. Conclusions. The current version of LinChemIn allows users to combine synthetic routes generated from various tools and analyze them, and constitutes an open and extensible framework capable of incorporating contributions from the community and fostering scientific discussion. Our roadmap envisages the development of sophisticated metrics for routes evaluation, a multi-parameter scoring system, and the implementation of an entire "ecosystem" of functionalities operating on synthetic routes. LinChemIn is freely available at https://github.com/syngenta/linchemin.
Benchmarking DFT functionals for excited-state calculations of Donor Acceptor TADF emitters: Insights on the key parameters determining Reverse Inter System Crossing
Authors: Hall David , Sancho Garcia Juan Carlos , Pershin Anton , Beljonne David , Zysman-Colman Eli , Olivier Yoann
Published: November 2022

The importance of intermediate triplet states and the nature of excited states has gained interest in recent years for the thermally activated delayed fluorescence (TADF) mechanism. It is widely accepted that simple conversion between charge transfer (CT) triplet and singlet excited states is too crude, and a more complex route involving higher-lying locally excited triplet excited states has to be invoked to witness the magnitude of the rate of reverse intersystem crossing (RISC) rates. The increased complexity has challenged the reliability of computational methods to accurately predict the relative energy between excited states as well as their nature. Here we compare the results of widely used DFT functionals, CAM-B3LYP, LC-ꞷPBE, LC-ꞷ*PBE, LC-ꞷ*HPBE, B3LYP, PBE0 and M06-2X against a wavefunction-based reference method, Spin-Component Scaling second-order approximate Coupled-Cluster (SCS-CC2) in fourteen known TADF emitters possessing a diversity of chemical structures. Overall, the use of the Tamm-Dancoff Approximation (TDA) together with the CAM-B3LYP, M06-2X and the two ꞷ-tuned range-separated functionals LC-ꞷ*PBE and LC-ꞷ*HPBE demonstrated the best agreement with SCS-CC2 calculations in predicting the absolute energy of the singlet S1, and triplet T1 and T2 excited states and their energy differences. However, consistently across the series and irrespective of the functional or the use of TDA, the nature of T1 and T2 is not as accurately captured as compared to S1. The presented work highlights that despite good agreement of energies, the description of the exact nature of the triplet states should be undertaken with caution.
PANCASILA ECONOMIC SYSTEM A LEGAL REFORM IN GLOBALIZATION ERA
Authors: Dany Bina Era , Daudsyah Teuku
Published: November 2022

Pancasila is the source of all legal sources that form the basis for the implementation of the economic system in Indonesia. The purpose of this study is to find out and analyze the economic legal system based on Pancasila which is the basis of the nation's ideology and the basic norms of the Indonesian nation in the era of globalization. the research method uses a normative juridical approach. The results of the study state that the renewal of economic law in Indonesia must be directed to create people's welfare, by relying on the values of Pancasila as the philosophy and way of life of the nation which becomes the guideline in the implementation of every aspect of the life of the nation, state and society. Pancasila contains the principle of gotong royong, and that is actually the core of the renewal of economic law which places mutual cooperation as a value that must be realized in the formulation of laws and regulations which then become the basis for realizing social welfare.
NOTARY AUTHORITY IN MAKING AUTHENTIC DEEDS REGARDING COPYRIGHT
Authors: Moertiono R. July , Mansar Adi
Published: November 2022

The issue of notary authority in the creation of authentic deeds regarding copyright since the authority of DJKI to directly record copyright. However, in the framework of copyright protection, an authentic notary deed is required to give validity to the copyright. The research method used is normative juridical. The results showed that in the Notary Copyright Act is also authorized to make authentic deeds of the copyright field in order to protect copyright works that will then be recorded to DJKI. In the HCAct, notaries have the authority to make authentic deeds of transfer over copyright. Transfer of copyright can be done from the copyright owner to another designated party. However, this transfer does not necessarily get all exclusive rights from the copyright owner. The designated party in the transfer can only get economic rights only. The moral rights to the intellectual property remain owned by the copyright owner. Although in the Act the transfer of copyright is done clearly and in writing either with or without a notary deed, it should be equipped with an authentic deed from a notary. This is based, this transfer of copyright is closely related to the transfer of economic rights, so it takes a deed that has strong legal evidentiary power.
THE CORPORATE CRIMINAL LIABILITY IN THE MANAGEMENT OF OIL PALM PLANTATION LAND
Authors: Afita Nur , Hartiwiningsih Hartiwiningsih
Published: November 2022

This study aims to analyze the form of criminal liability against corporations in the management of oil palm plantation land, especially in West Kalimantan province. Therefore, the corporation as an entity in its development is capable of committing acts against the law such as in the management of oil palm plantations. However, the actual form of criminal liability often contains anomalies in it, especially in the Province of West Kalimantan. This research is empirical legal research or a prescriptive sociological legal research using a statutory approach, and case approach. Analyze what are the obstacles in delegating criminal responsibility to corporations in the field of oil palm plantation land management. The results study show that the form of criminal liability against corporations in the management of oil palm plantations is a criminal fine that can be represented by a senior officer in court. Second, obstacles in delegating responsibility to corporations are caused by several factors, namely (1) the formulation (2) the application (3) the execution.