bluuebunny/crossref_metadata_2025 huggingface dataset:
ФРУСТРАЦІЙНА ТОЛЕРАНТНІСТЬ ЯК СКЛАДОВА ПСИХОЛОГІЧНОЇ ГОТОВНОСТІ РЯТУВАЛЬНИКІВ ДО ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ
Authors: Чередниченко Т. В.
Published: April 2024

Стаття присвячена проблемі фрустраційної толерантності у професійній діяльності рятувальників ДСНС України. У статті розкрито психологічний зміст поняття фрустрації та фрустраційної толерантності, визначено теоретико-методологічні підходи до визначення досліджуваного психічного явища. Зазначено, що здатність людини протистояти фрустраційним ситуаціям без деструктивних наслідків, адекватно їх оцінювати, управляти виникненням і динамікою психічного стану фрустрації, демонструвати конструктивне поводження під час подолання перешкод залежить від рівня розвитку її фрустраційної толерантності, що є індивідуально-психологічною якістю, яка детермінує стійкість до фрустрації. З’ясовано, що однією з найважливіших характеристик психологічної готовності рятувальників до професійної діяльності є здатність керувати психічними станами, що виникають у результаті впливу екстремальних умов, зокрема фрустрацією. Проаналізовано основні підходи до тлумачення фрустраційної толерантності, виокремленні основні рівні фрустраційної толерантності, які визначають реакцію та поведінкові особливості на дію різних видів фрустраторів. Виокремлено найбільш типові способів поведінки в стані фрустрації. Зазначено, що наявність численних стрес-факторів професійної діяльності створює значні труднощі рятувальникам, погіршує їх фізичний стан, викликає виникнення цілої низки негативних психічних станів, зокрема фрустрації. Інтенсивність негативної дії стрес-факторів значно знижується, якщо рятувальники своєчасно підготовлені до екстремальних умов не тільки професійно, але і психологічно. Доведено, що здатність рятувальника переносити ситуації фрустрації без деструктивних наслідків залежить від рівня розвитку його толерантності до фрустрації, що є обов’язковою для нормального функціонування особистості, особливо у тих випадках, коли виникнення ситуацій фрустрацій пов’язане з бар’єрами, які є необхідними або об’єктивно непереборними. Розглянуто показники психологічної готовності/неготовності рятувальників до професійної діяльності в екстремальних умовах.
Síncope recurrente por fibrilación auricular paroxística como forma de presentación de hipertiroidismo apático
Authors: Ferreira-Bacciarini Joaquín
Published: April 2024

El hipertiroidismo apático es una forma de presentación poco frecuente de hipertiroidismo, caracterizada por la ausencia de los síntomas clásicos de hipermetabolismo generados por el aumento en la síntesis de hormonas tiroideas. Afecta mayormente a personas de edad avanzada, y puede manifestarse como enfermedad cardiovascular, con arritmias cardiacas. A continuación, se comunica un caso de hipertiroidismo apático secundario a adenoma tiroideo tóxico, que se presentó con síncope recurrente relacionado a fibrilación auricular paroxística.
Fungoma intracardiaco como manifestación atípica de coccidioidomicosis diseminada
Authors: Valencia-Álvarez Sharon Jessrel , Epitacio-Neri Beatriz , Parra-Flores Jessica Jael
Published: April 2024

La coccidioidomicosis afecta primordialmente al tejido pulmonar. Cursa de forma asintomática en el 50% de los casos, pero el 1% se manifiesta con diseminación hacia otros órganos, siendo la afectación cardiaca extremadamente rara. Describimos el caso de un paciente diagnosticado con coccidioidomicosis meníngea con diseminación a las cavidades cardiacas cursando como Endocarditis Infecciosa por la presencia de un fungoma.
Microangiopatía trombótica en el seno de una prostatitis aguda
Authors: Muñoz-Blanco Arturo , Pérez-Monte Mínguez Beatriz , Fuerte-Martínez Rebeca , Valle-López José Luis , Gómez-Cerezo Jorge Francisco
Published: April 2024

Presentamos el caso de un varón de 46 años que ingresó por un episodio de prostatitis aguda y durante la hospitalización presentó un deterioro progresivo y severo de la función renal acompañado de anemia hemolítica y trombocitopenia severa. Tras estudio etiológico se llegó al diagnóstico de una microangiopatía trombótica. Se inició tratamiento con eculizumab y plasmaféresis con buena respuesta.
Staffing and human resource assignment in U-shaped production cells
Authors: Bányai Tamás , Kaczmar Ireneusz
Published: April 2024

Today, U-shaped production cells play an important role in manufacturing, as their flexibility allows for highly efficient production with a small number of operators. Since the cost of human resources has a significant impact on the total cost of the overall production process and the assignment of operators to tasks can have a major impact on the efficiency of the production process, it is important to develop design methods that allow the assignment of resources to tasks in a way that maximizes the efficiency of the U-cell manufacturing system. In this paper, the authors present a mathematical model for assigning operators to task sets using different objective functions. Calculations based on the presented mathematical model demonstrate that, given a suitable choice of objective functions, it is possible to determine an optimal operator-task assignment that can improve the efficiency of the manufacturing system.
Possibilities of using driverless handling robots in intralogistics
Authors: Komáromi Balázs , Szentesi Szabolcs
Published: April 2024

In this article we deal with production logistics within internal logistics, as well as the material supply of production, as well as the related material handling and the use of material handling robots supporting processes. Robot navigation is a multi-approach discipline that poses a major challenge in intralogistics. In general, the navigation principle, software and hardcer requirements of mobile robots must be prepared on the basis of logistics processes in such a way as to satisfy production with sufficient accuracy and safety. In the article we present the types of robots and give an insight about autonomous mobile robots.
Mobile handling units in advanced material handling systems
Authors: Telek Péter
Published: April 2024

To fulfil the increasing requirements of the social and economic environments, the equipment used in material handling processes have to be developed. The machines fitted exactly to certain manufacturing procedures some decades ago, cannot be found in the advanced version, they role are acted by other, earlier rarely used computer-controlled devices. The traditional method for the material handling is the using of mobile handling units, where the goods are moving on the machines, so the characteristics of the transportation are based on the parameters of the handling equipment. Suited to the new requirements, the structure and operation of the mobile handling units are changing but their application have similar conditions. There are many handling machines belonging to this category, this paper gives an overview about their most popular variations and their usability in advanced material handling systems.
Implementation of modelling ship-to-sequence supply strategies
Authors: Juhász János , Bányai Tamás
Published: April 2024

The supply chain optimization is key to improving the cost efficiency and sustainability of manufacturing and service companies. One of the most innovative strategies is just-in-sequence supply, which offers improvements over traditional just-in-time approaches. This paper focuses on the implementation of ship-to-ship supply, especially to mathematical modeling of just-in-sequence strategies. It not only evaluates the entire supply process, but this approach allows for a comprehensive analysis of the financial impact of ship-to-ship supply for both suppliers and end-users. It goes beyond the analysis of the entire supply process; it allows an examination of selected processes at deeper levels and evaluates the impact of different factors on financial indicators.
Phonological Processes Triggered by Means of Verbs Conjugation in Bantu Languages
Authors: Simon Chipanda
Published: April 2024

This study explores the complex relationship between phonological processes and verb extensions, focusing on the concept of word elasticity, which describes the transformations words undergo based on linguistic contexts. Anchored in the Generative Phonology Theory, which postulates a transition from underlying representation to surface structure, the research aims to understand the phonological outcomes stemming from verb extension morphology, particularly in Bantu languages. Employing a qualitative approach through a documentary systematic review of peer-reviewed literature and academic articles across diverse languages, findings reveal multiple phonological processes, such as elision, assimilation, and palatalization, demonstrating the dynamic shifts induced by verb conjugations. The study concludes that understanding the interplay between morphology and phonology is fundamental, emphasizing the transformative nature of verb extensions in shaping phonological processes across languages.
Monetary Policy Challenges and Strategies in the Globalization: An Analysis of the Federal Reserve's Approach to the Trilemma
Authors: Ji Guofang
Published: April 2024

This study explores the Federal Reserve's (Fed's) approach to the financial trilemma in the era of globalization, emphasizing the trade-offs between monetary policy autonomy, exchange rate flexibility, and open capital markets. It delves into the challenges posed by increased global financial integration and the effectiveness of traditional and innovative monetary tools. The paper advocates for the adoption of a macroprudential policy framework to enhance financial system stability without compromising policy objectives. The findings highlight the Fed's strategic use of macroprudential measures alongside conventional tools to navigate the trilemma, illustrating the importance of flexibility and innovation in central banking practices amidst global financial complexities.
Yaşlı Göçmen Olmak Türkiye’de Yaşlı Suriyelilerin Hizmet Alımındaki Konumları
Authors: Apak Emrah , Artan Taner
Published: April 2024

Yaşlı göçmenler, göçmen grubu içerisinde iki kat dezavantajlı konumda olan bu nedenle sorun ve ihtiyaçları dikkatle ele alınması gereken bir grubu oluşturmaktadır. Yaşlı göçmenler, fiziksel yetersizlik, göç sonrasında çalışamama gibi faktörlerden dolayı göç sürecinde ve göç sonrası süreçte diğer yaş gruplarına göre daha fazla zorluk çekmektedirler. Alışılmış olan sosyal ağlardan kopma, göç edilen yerde çalışamamaktan dolayı aile üyelerine bağımlı olma, yeni kültüre uyum sağlamada yaşanan zorluklar yaşlıların daha kırılgan olabileceğini düşündürmekte, bundan dolayı bu çalışmada yaşlı göçmenlere odaklanılmaktadır. Bu çalışmada, göçmenler içerisinde kırılgan bir grup olan yaşlıların sorunlarının neler olduğu ve Türkiye’de kamu, sivil toplum kuruluşları ve belediyeler tarafından sunulan hizmetlerin incelenmesi amaçlanmaktadır. Yaşlı göçmenlerin yaşadıkları sorunlar; sosyo-kültürel uyum, istihdam, sosyo-ekonomik durum, fiziksel ve ruhsal sağlık, sosyal destek alanlarında yoğunlaşmaktadır. Türkiye’de yaşlı göçmenlere yönelik kamu, belediye ve STK’lar tarafından sunulan hizmetlerin özelde yaşlılara yönelik sınırlı düzeyde var olduğu, genel göçmen nüfusa sunulan hizmetlerden yaşlı göçmenleri yararlandıkları söylenebilir. Dolayısıyla, hizmet sunumlarında yaşlı göçmenlerin yaşadıkları sorunların göz önünde bulundurularak hizmet modellerinin yeniden düzenlenmesi gerektiği önerilebilir.
Legal Dilemma between Law on Protection Child and Marriage Law in Addressing Early Marriage
Authors: Tan Winsherly , Agustianto Agustianto , Febri Jaya
Published: April 2024

This study aims to analyze marriage regulations with child protection, namely Law Number 16 of 2019 on Marriage and Law Number 35 of 2014 on Child Protection. These two regulations will be analyzed to protect children who marry underage. The study method used is normative juridical. As a novelty, the study tries to compare marriage arrangements with child protection arrangements. The purpose and perspective of underage marriage between the two regulations are different. The research results show that marriage law has a different spirit than child protection law. This is shown in the marriage law, which states that children are still allowed to marry for urgent reasons by applying for a dispensation to the court. However, child protection law explicitly does not allow this. Therefore, there is a need for more detailed regulation regarding the category of "urgent reasons" regulated in the marriage law.
Keywords: Marriage; Children; Protection.
Recruitment limitation increases susceptibility to fishing-induced collapse in a spawning aggregation fishery
Authors: Jarvis Mason ET , Riecke TV , Bellquist LF , Pondella DJ II , Semmens BX
Published: April 2024

Spawning aggregation-based fisheries are notorious for booms and busts driven by aggregation discovery and subsequent fishing-induced collapse. However, environment-driven sporadic recruitment in some since-protected populations has delayed recovery, suggesting recruitment-limitation may be a key driver of their population dynamics and fishery recovery potential. To glean insight into this dynamic, we focused on an overexploited temperate aggregate spawner, barred sand bass Paralabrax nebulifer, and leveraged a long-term mark-recapture data set spanning different oceanographic and harvest histories in a custom Bayesian capture-mark-reencounter modeling framework. We coupled this demographic analysis with long-term trends in sea surface temperature, harvest, adult and juvenile densities, and historical accounts in the literature. Our results point to a history of multidecadal windows of fishing opportunity and fishing-induced collapse largely driven by sporadic, warm-water recruitment events, in which recruits may be externally sourced and local recruitment is negatively influenced by harvest. Following the last collapse, recruitment remained elevated due to novel, anomalously warm conditions. Despite signs of incipient population recovery, spawning aggregations remain absent, indicating that other potential factors (e.g. continued fishing during spawning season, Allee effects) have delayed fishery recovery to date. Recruitment-limited aggregate spawner populations, especially those at their geographic margins, are highly susceptible to sudden and potentially extended periods of collapse, making them ill-suited to high catch-per-unit-effort fishing that occurs on spawning grounds. If the goal is to balance protecting spawning aggregations with long-term fishery sustainability, then limiting aggregation-based fishing during the spawning season is likely the best insurance policy against collapse and recovery failure.
Pelaksanaan Dinding Penahan Tanah Kantilever (Cantilever Retaining Wall) Pada Pekerjaan Pembangunan Fly Over Sekip Ujung
Authors: Prawijaya Muhammad Tarish , Sutabri Tata , Wahab Wahyuni , Firdaus Firdaus
Published: April 2024

Dinding penahan tanah merupakan struktur bangunan yang menahan tanah atau memberikan kestabilan gaya horizontal tekan tanah aktif atau bahan lain yang memiliki beda ketinggian dan tidak memperbolehkan tanah memiliki kemiringan longsor lebih dari kemiringan alaminya. Supaya dapat menahan tanah yang memiliki kondisi khusus tersebut, konstruksi ini harus mampu memberikan kestabilan terhadap pengaruh gaya-gaya eksternal maupun gaya-gaya internal. Fungsi utama dari konstruksi penahan tanah adalah menahan tanah yang berada dibelakangnya dari bahaya longsor akibat benda-benda yang ada diatas tanah (perkerasan & konstruksi jalan, jembatan, kendaraan, dll), berat tanah, dan berat air dalam tanah.
Sosialisasi Peran Komunikasi Interpersonal dalam Pembelajaran Inklusif di SD Plus Ditawijaya Palembang
Authors: Kesumawati Shakira Atesya , Misnawati Desy , Kesumawati Selvi Atesya
Published: April 2024

Komunikasi interpersonal merupakan proses pertukaran informasi antara 2 orang atau lebih dengan berbagai efek dan umpan balik untuk membangun hubungan yang kuat dan efektif. Tujuan dari kegiatan pengabdian ini adalah untuk memberikan sosialisasi peranan komunikasi interpersonal antara guru dan siswa pada pembelajaran inklusif di SD Plus Ditawijaya Palembang. Kegiatan pengabdian ini dilaksanakan dengan bentuk sosialisasi (paparan) oleh tim pengabdian mengenai peran komunikasi interpersonal dalam pembelajaran inklusi. Hasil kegiatan pengabdian ini menunjukkan bahwa guru-guru di SD Plus Ditawijaya memperoleh pengetahuan komunikasi interpersonal antara guru dan siswa untuk menunjang komunikasi yang efektif dalam menciptakan dan mencapai tujuan pembelajaran inklusif.
Pengabdian Edukasi Cegah Stunting untuk Masyarakat di Desa Maranatha Kabupaten Sigi
Authors: Kamaludin Tutang Muhtar , Susilawati Susi , Yusril Yusril , Nirmalawati Nirmalawati , Nadrun Nadrun , Asnudin Andi
Published: April 2024

Kegiatan pengabdian masyarakat Kuliah Kerja Nyata merupakan program yang dilaksanakan oleh Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Tadulako sebagai mata kuliah wajib di lapangan dengan tema “Membangun Generasi Gemilang Melalui Edukasi Cegah Stunting". Pencegahan stunting dan pendampingan bagi masyarakat di Desa Maranata Kecamatan Sigi Kota Kabupaten Sigi Provinsi Sulawesi Tengah. Stunting menjadi permasalahan karena dapat menyebabkan terjadinya kesakitan, kematian, melambatnya proses perkembangan motorik dan menghambat proses pertumbuhan mental penderita. Sasaran dari kegiatan penyuluhan berbentuk edukasi kepada masyarakat tentang Stunting Edukasi Pentingnya Pencegahan Pernikahan Usia Dini Edukasi Penyuluhan Air Susu Ibu (ASI) Paripurna Edukasi Pentingnya Mengkonsumsi Makanan Yang Bergizi dan Sehat dan Aksi Kebersihan Lingkungan Desa. Hasil dari kegiatan ini menunjukkan adanya peningkatan pemahaman masyarakat mengenai apa itu stunting, penyebab stunting, bahaya stunting untuk jangka pendek dan panjang serta tumbuhnya kesadaran dalam menanggulangi dampak dari stunting sehingga dapat meminimalisir terjadinya stunting pada anak sedini mungkin.
Mandeville’s Moralists: Hume, Smith, and the Framing of Moral Virtue
Authors: Byham Jack C.
Published: April 2024

Bernard Mandeville’s theory of morality – ‘private vices, public benefits’ – provides a frame for comparing Adam Smith and David Hume on utility. Mandeville held that vice, not virtue, is useful for society. For him, the private and public good do not align. What is bad for individuals is often beneficial for society and vice versa. To counter Mandeville’s rhetoric and show the attractiveness of virtue, Hume places the principle of utility at the center of his An Enquiry concerning the Principles of Morals (1751). This placement directs the reader’s attention away from the lack of alignment between private and public advantage and enables Hume to ‘dress’ moral virtue in utility and pleasure. Smith, by contrast, places the principle of propriety at the center of The Theory of Moral Sentiments (1759). This is because he is closer in spirit to Mandeville than is Hume in acknowledging a gap between the private and public good. By directing the reader’s attention to this gap in Part IV, Smith tries to show, contra Hume, that the principle of propriety, not utility, better explains and defends praiseworthy action and choice in an imperfect world.
Is Shepherd a Monist?
Authors: Landy David
Published: April 2024

For Shepherd, how many things exist? On the one hand, it looks like the answer is going to be many. It is a central tent of Shepherd's philosophical system that causation is a relation whereby two or more objects combine to create a third. Since there are many instances of this causal relation, there must be many objects in the world. On the other hand, there are several moments throughout her writing where Shepherd indicates that the distinction between causes and effects is in some sense unreal, and that while the world appears to us to consist of many distinct objects interacting causally, really there is just one thing and its merely nominally distinct parts. I argue that Shepherd is an ontological pluralist, and the texts that appear to express a commitment to ontological monism are best understood as expressing ontological holism instead.
Enhancing wildfire risk assessment through weather modeling and machine learning: a case study in Orange County, USA
Authors: Kahono Lulus Adhitya
Published: April 2024

Forest wildfire is a significant threat, causing extensive environmental damage and loss of life. Accurate and effective risk assessments are essential for better understanding and mitigating this risk. In this study, we propose a novel approach that combines weather modeling and machine learning for improved wildfire risk assessment. Our case study focuses on Orange County, USA, known for its high wildfire susceptibility. The methodology involves collecting historical weather and wildfire data in the region. We employ a machine learning model that integrates weather data with other factors, including vegetation and topography, to predict wildfire risk. Through machine learning techniques, we analyze the relationships among these variables and generate accurate risk predictions for Orange County. Results indicate a significant enhancement in wildfire risk assessment with this approach. The developed model provides valuable insights into the factors influencing wildfires, aiding authorities, and policymakers in implementing effective mitigation strategies. By leveraging weather modeling and machine learning, we can enhance our understanding and management of wildfire risks, safeguarding the environment and communities. This research highlights the potential of these technologies to improve wildfire mitigation efforts. The findings contribute to a proactive approach to addressing the serious threat of forest wildfires.
Business model canvas analysis of organic fertilizer “Goat Waste”
Authors: Najih Mohammad Shohwan
Published: April 2024

This study aims to determine the use of organic fertilizer in adding soil nutrients and analyze the implementation of BMC in the organic fertilizer business. This study was carried out directly at the production location using observation and interview methods. The results study show that organic fertilizer is produced using goat waste as raw material. Goat waste is processed using certain techniques to produce organic fertilizer, easy to use, and aplicable to any plants. Organic fertilizer continues to be produced for use on one’s own land as a substitute for synthetic chemicial fertilizer. The result study also show that in soil goven organic fertilizer the plants grow well. The result study also show that in the organic fertilizer business the company has used Business Model Canvas (BMC) which includes : Value proposition, Key partners, Key activities, Key Resources, Customer Relationships, Custumer Segments, Channels, Cost Structure and Revenue Streams. The use of BMC has an influence on the sustainability of this business.
effect of positioning and product differentiation on consumer loyalty of Indomie instant noodles
Authors: Banjarnahor Susi , Hardini Sri Yuniati Putri Koes , Gandhy Abel
Published: April 2024

The competition between industries in the food sector in the modern era has increased significantly. One of the significant instant noodle brands is Indomie. The companies must create a strategy to increase income and profits and maintain market share. The objective of the research to analyze the influence of positioning and product differentiation on the consumer loyalty of Indomie instant noodles. The method of this research used a quantitative descriptive. The sample for this research had as many as 100 respondents. The technique of sampling used a purposive sampling. The technique of data analysis is a multiple linear regression analysis using the classical assumption test, F-test, t-test, and coefficient of determination test. The data was processed using the SPSS-25 program. The results show that positioning and product differentiation are significant to consumer loyalty to Indomie instant noodles. Partially, the positioning positively and significantly affects consumer loyalty to Indomie instant noodles. At the same time, product differentiation has no significant on consumer loyalty. The coefficient of determination test (R²) shows that positioning and product differentiation have an effect of 50.8% on consumer loyalty, while other variables influence 49.2%. Companies should increase product differentiation by attempting instant noodle variants made with healthier ingredients.
Fruit consumption improvement as an effort to sustainable lifestyle
Authors: Fadila Ila , Nurunisa Venty Fitriany
Published: April 2024

The integration of healthy diets into sustainable lifestyles faces challenges as modern living often sidelines nutritional choices. While the World Health Organization (WHO) recommends 150 grams of fruit daily per capita, Statistics Indonesia (2021) reports an average consumption of only 81.14 grams, meeting just 54.09% of the WHO's minimum nutritional adequacy. This qualitative descriptive study aims to analyze the knowledge, attitude, and actions influencing fruit consumption in Indonesia. Primary data, collected through questionnaires, reveal that respondents generally possess good knowledge and attitude towards fruit benefits. However, discrepancies arise in the action aspect, with consumption frequency falling below recommended standards. Utilizing the Scopus publication database and Vosviewer software, bibliometric analysis identifies key keywords like female, male, adult, fruit, diet, and food intake in Indonesian fruit consumption research. Despite positive attitudes and awareness, actual fruit consumption remains suboptimal, emphasizing the need for targeted interventions to bridge the gap between knowledge and practice.
characteristics of tape with different packaging materials: a review
Authors: Ulfah Mutiara , Sulistyawati Sulistyawati
Published: April 2024

Tape is a traditional Indonesian fermented food made from cassava or glutinous rice. Tape is usually presented at special events in various regions of Indonesia. Tape is generally wrapped and packaged traditionally using leaves. Nowadays, tape is also packaged in plastic and cardboard boxes. Based on traditional packaging using natural packaging materials, several types of leaves are used as tape wrappers, but the most used are banana leaves and guava leaves. This study aims to determine the effect of tape packaging materials on the characteristics of the tape. The method used is a systematic review by collecting scientific articles from Scopus, Research Gate, and Google Scholar by focusing on the keywords tape, wrapping food, and plant packaging. From the total number of articles obtained, some relevant papers were selected for discussion in this study. The information used focuses on the effect of packaging on the characteristics of the tape produced, the organoleptic properties of the tape, and the shelf life of the tape. The study's results found several types of packaging used in packing tape, including banana leaves, guava leaves, pandan leaves, woven bamboo, cardboard boxes, and plastic. The difference in the packaging used affects the sensory properties of the tape produced, such as tape color, aroma, and taste.
Survey of HPV genotypes using multiplex PCR and flow through hybridization in Jakarta, Indonesia
Authors: Jannah Angelia Lailatul , Jacksen Jacksen , Saraswaty Indah , Suwati Suwati , Diki Diki
Published: April 2024

This is a study to identify genotypes of Human Papilloma Virus (HPV) among women in Jakarta. The virus increases the risk of cervical cancer, which the second highest incident of cancer in Indonesia. Although there is vaccination program to prevent infection of HPV, it must be based on prior screening of recipients based on HPV genotypes. Each genotype has different potential causing premalignant lesion. Most previous studies are not defining the genotypes of HPV. Therefore, this study is conducted to survey genotypes of HPV using Multiplex PCR and Flow Through Hybridization. The Multiplex PCR and Flow Through Hybridization can detect 35 genotypes, consisting of 18 high risk and 17 low risk genotypes. Samples are patients who visit a clinic in Jakarta. Most of them are women who are already married and between 20 and above 50 years of age. Samples are collected between August to November 2022. There are 336 samples. The result shows that 53.57% of samples were detected positive for HPV. The most prevalent high-risk genotype is genotype 52 while the most prevalent low risk is genotype 11. There are 15,74% of cases of co-infection. The genotype 11 is the genotype that are the most often found in co-infection. The finding is not reported in previous studies. The Multiplex PCR and Flow Through Hybridization can detect genotypes of HPV.
Motivação para prática de musculação das mulheres da cidade de Ubá-MG
Authors: Oliveira Adenilson Flávio de , Leite Luciano Bernardes , Rosado Daniela Gomes , Costa Sebastião Felipe Ferreira , Moura Anselmo Gomes de , Lavorato Victor Neiva
Published: April 2024

A motivação é necessária para que indivíduos comecem a praticar alguma atividade física, sendo qual for seu objetivo. Assim sendo, o objetivo deste trabalho foi identificar os principais fatores motivacionais que levam as mulheres da cidade de Ubá-MG a realizarem a prática de musculação. A pesquisa foi realizada com 50 mulheres praticantes de musculação, com idade de 20 a 60 anos, em uma academia da cidade de Ubá-MG. O instrumento empregado foi a Escala de Motivação à prática de Atividade Física (MPAM-R). Essa escala classifica a motivação em cinco fatores para a prática da atividade física: Diversão, Saúde, Aparência, Competência e Social, com perguntas baseadas em uma escala de sete pontos, que varia de 1 = discordo totalmente a 7 = concordo totalmente. A análise de dados foi realizada por meio da aplicação da estatística descritiva (média e desvio padrão, além de porcentagem simples). A distribuição foi avaliada pelo teste de Shapiro-Wilk. Para identificação dos fatores motivacionais mais presentes nas avaliadas, foi utilizado ANOVA de uma via, com post hoc de Tukey. O nível de significância adotado foi de 5%. Os dados foram analisados por meio do programa estatístico Graph Pad Prism 8.1®. Observou-se que o principal fator motivacional apresentado foi saúde (6,18±1,12), seguido de diversão (5,12±1,57), aparência (5,12±1,09), competência (4,61±1,76) e social (3,54±1,59). Conclui-se que o principal motivo para prática de musculação das mulheres foi saúde, contudo é necessário o aprofundamento de novos estudos, podendo analisar a divisão de sexos ou até mesmo uma faixa etária específica.
Determination of apparent and standardized ileal digestibility of amino acids in corn HP-DDG fed to growing pigs
Authors: da Motta Stephane Alverina Briguente , Barcellos Joyce , Lourenço Antônio Carlos Macedo , Ramos Bruno Teixeira , Lima Ideraldo Luiz , Mike Brian Patrick , Rennó Luciana Navajas , Hannas Melissa Izabel
Published: April 2024

The corn-based ethanol production industry provides co-products with potential value as animal feed. However, the nutritional value of these co-products should be adequately determined for their sustainable implementation in swine diets. Therefore, a study was conducted to determine the concentration of amino acids (AA), apparent ileal digestible amino acids (AID), standardized ileal digestible amino acids (SID), and crude protein (CP) in corn distillers dried grains with high protein content (corn HP-DDG) for pigs. Six growing pigs (initial body weight: 46.30 ± 2.14 kg) were surgically fitted with a T-cannula at the distal ileum and allotted to a duplicate 2 × 3 incomplete Latin Square Design. Diets containing corn HP-DDG as the only AA source and a nitrogen-free diet (NFD) were formulated. Corn HP-DDG was used as a test ingredient to replace 40% of the starch in NFD, and titanium dioxide (0.5%) was added as an indigestible marker to both diets. Pigs were fed between 08:00 and 18:00 h during five days of adaptation and a sequence of two days of ileal digesta collection. On an as-fed basis, the chemical composition of corn HP-DDG was 40.41% CP, 1.39% lysine, 1.57% methionine + cysteine, 1.61% threonine, 0.23% tryptophan, and 2.15% valine. The AID and SID values of corn HP-DDG were 74.04% and 80.87% for CP; 76.32% and 79.15% for lysine; 84.75% and 86.52% for methionine + cysteine; 71.97% and 78.30% for threonine; 83.86% and 92.44% for tryptophan; and 76.34% and 80.47% for valine, respectively. In conclusion, the SID CP and AA in corn HP-DDG were within the previously published values, and the determined SID coefficients should be used to formulate accurate diets for pigs.
Enhancing the implantation of mechanical circulatory support devices using computational simulations
Authors: Lopez-Santana Gabriela , De Rosis Alessandro , Grant Stuart , Venkateswaran Rajamiyer , Keshmiri Amir
Published: April 2024

Introduction: Patients with end-stage heart failure (HF) may need mechanical circulatory support such as a left ventricular assist device (LVAD). However, there are a range of complications associated with LVAD including aortic regurgitation (AR) and thrombus formation. This study assesses whether the risk of developing aortic conditions can be minimised by optimising LVAD implantation technique.

Methods: In this work, we evaluate the aortic flow patterns produced under different geometrical parameters for the anastomosis of the outflow graft (OG) to the aorta using computational fluid dynamics (CFD). A three-dimensional aortic model is created and the HeartMate III OG positioning is simulated by modifying (i) the distance from the anatomic ventriculo-arterial junction (AVJ) to the OG, (ii) the cardinal position around the aorta, and (iii) the angle between the aorta and the OG. The continuous LVAD flow and the remnant native cardiac cycle are used as inlet boundaries and the three-element Windkessel model is applied at the pressure outlets.

Results: The analysis quantifies the impact of OG positioning on different haemodynamic parameters, including velocity, wall shear stress (WSS), pressure, vorticity and turbulent kinetic energy (TKE). We find that WSS on the aortic root (AoR) is around two times lower when the OG is attached to the coronal side of the aorta using an angle of 45° ± 10° at a distance of 55 mm.

Discussion: The results show that the OG placement may significantly influence the haemodynamic patterns, demonstrating the potential application of CFD for optimising OG positioning to minimise the risk of cardiovascular complications after LVAD implantation.
Comparison between left bundle branch area pacing and right ventricular pacing: ventricular electromechanical synchrony and risk of atrial high-rate episodes
Authors: Yang Wang-Yang , Di Bei-Bing , Peng Hui , Sun Zhi-Jun
Published: April 2024

Background

The electromechanical dyssynchrony associated with right ventricular pacing (RVP) has been found to have adverse impact on clinical outcomes. Several studies have shown that left bundle branch area pacing (LBBAP) has superior pacing parameters compared with RVP. We aimed to assess the difference in ventricular electromechanical synchrony and investigate the risk of atrial high-rate episodes (AHREs) in patients with LBBAP and RVP.

Methods

We consecutively identified 40 patients with atrioventricular block and no prior atrial fibrillation. They were divided according to the ventricular pacing sites: the LBBAP group and the RVP group (including the right ventricular apical pacing (RVA) group and the right side ventricular septal pacing (RVS) group). Evaluation of ventricular electromechanical synchrony was implemented using electrocardiogram and two-dimensional speckle tracking echocardiography (2D-STE). AHRE was defined as event with an atrial frequency of ≥176 bpm lasting for ≥6 min recorded by pacemakers during follow-up.

Results

The paced QRS duration of the LBBAP group was significantly shorter than that of the other two groups: LBBAP 113.56 ± 9.66 ms vs. RVA 164.73 ± 14.49 ms, p < 0.001; LBBAP 113.56 ± 9.66 ms vs. RVS 148.23 ± 17.3 ms, p < 0.001. The LBBAP group showed shorter maximum difference (TDmax), and standard deviation (SD) of the time to peak systolic strain among the 18 left ventricular segments, and time of septal-to-posterior wall motion delay (SPWMD) compared with the RVA group (TDmax, 87.56 ± 56.01 ms vs. 189.85 ± 91.88 ms, p = 0.001; SD, 25.40 ± 14.61 ms vs. 67.13 ± 27.40 ms, p < 0.001; SPWMD, 28.75 ± 21.89 ms vs. 99.09 ± 46.56 ms, p < 0.001) and the RVS group (TDmax, 87.56 ± 56.01 ms vs. 156.46 ± 55.54 ms, p = 0.003; SD, 25.40 ± 14.61 ms vs. 49.02 ± 17.85 ms, p = 0.001; SPWMD, 28.75 ± 21.89 ms vs. 91.54 ± 26.67 ms, p < 0.001). The interventricular mechanical delay (IVMD) was shorter in the LBBAP group compared with the RVA group (−5.38 ± 9.31 ms vs. 44.82 ± 16.42 ms, p < 0.001) and the RVS group (−5.38 ± 9.31 ms vs. 25.31 ± 21.36 ms, p < 0.001). Comparing the RVA group and the RVS group, the paced QRS duration and IVMD were significantly shorter in the RVS group (QRS duration, 164.73 ± 14.49 ms vs. 148.23 ± 17.3 ms, p = 0.02; IVMD, 44.82 ± 16.42 ms vs. 25.31 ± 21.36 ms, p = 0.022). During follow-up, 2/16 (12.5%) LBBAP patients, 4/11 (36.4%) RVA patients, and 8/13 (61.5%) RVS patients had recorded novel AHREs. LBBAP was proven to be independently associated with decreased risk of AHREs than RVP (log-rank p = 0.043).

Conclusion

LBBAP generates narrower paced QRS and better intro-left ventricular and biventricular contraction synchronization compared with traditional RVP. LBBAP was associated with a decreased risk of AHREs compared with RVP.
Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques
Authors: Brandes Florian , Meidert Agnes S. , Kirchner Benedikt , Yu Mia , Gebhardt Sonja , Steinlein Ortrud K. , Dolch Michael E. , Rantner Barbara , Tsilimparis Nikolaos , Schelling Gustav , Pfaffl Michael W. , Reithmair Marlene
Published: April 2024

Background

Atherosclerosis is a widespread disorder of the cardiovascular system. The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. It is known that extracellular vesicles (EVs) are important in intercellular communication in atherosclerotic disorders and carry many components of their cells of origin, including microRNAs (miRNAs). In this study, we test the assumption that miRNAs present in material acquired from plaques in patients undergoing surgery for atherosclerotic carotid artery stenosis are also expressed in circulating EVs obtained from the identical patients. This would allow the adoption of a liquid biopsy approach for the detection of plaques.

Methods

We studied 22 surgical patients with atherosclerotic carotid arterial stenosis and 28 healthy controls. EVs were isolated from serum by precipitation. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients. A comparative analysis was performed to identify circulating atherosclerosis-associated miRNAs that are also detectable in plaques.

Results

Seven miRNAs were found to be differentially regulated in patient serum compared with the serum of healthy controls. Of these, miR-193b-5p, miR-193a-5p, and miR-125a-3p were significantly upregulated in patients compared with that in healthy controls and present in both, circulating EVs and plaque material. An overrepresentation analysis of experimentally validated mRNA targets revealed an increased regulation of inflammation and vascular growth factors, key players in atherosclerosis and plaque formation.

Conclusion

Our findings suggest that circulating EVs reflect plaque development in patients with symptomatic carotid artery stenosis, which can serve as biomarker candidates for detecting the presence of atherosclerotic plaques.
Causal relationship between basal metabolic rate and kidney function: a bidirectional two-sample mendelian randomization study
Authors: Zhou Chaomin , Peng Yanzhe , Zhan Lin , Zha Yan
Published: April 2024

Background

The relationship between basal metabolic rate (BMR) and Chronic kidney disease (CKD) remains unclear and controversial. In this study, we investigated the causal role of BMR in renal injury, and inversely, whether altered renal function causes changes in BMR.

Methods

In this two-sample mendelian randomization (MR) study, Genetic data were accessed from published genome-wide association studies (GWAS) for BMR ((n = 454,874) and indices of renal function, i.e. estimated glomerular filtration rate (eGFR) based on creatinine (n =1, 004, 040), CKD (n=480, 698), and blood urea nitrogen (BUN) (n =852, 678) in European. The inverse variance weighted (IVW) random-effects MR method serves as the main analysis, accompanied by several sensitivity MR analyses. We also performed a reverse MR to explore the causal effects of the above indices of renal function on the BMR.

Results

We found that genetically predicted BMR was negatively related to eGFR, (β= −0.032, P = 4.95*10-12). Similar results were obtained using the MR-Egger (β= −0.040, P = 0.002), weighted median (β= −0.04, P= 5.35×10-11) and weighted mode method (β= −0.05, P=9.92×10-7). Higher BMR had a causal effect on an increased risk of CKD (OR =1.36, 95% CI = 1.11-1.66, P =0.003). In reverse MR, lower eGFR was related to higher BMR (β= −0.64, P = 2.32×10-6, IVW analysis). Bidirectional MR supports no causal association was observed between BMR and BUN. Sensitivity analyses confirmed these findings, indicating the robustness of the results.

Conclusion

Genetically predicted high BMR is associated with impaired kidney function. Conversely, genetically predicted decreased eGFR is associated with higher BMR.
Rapid carbon emission measurement during the building operation phase based on PSO–SVM: electric big data perspective
Authors: Wei Yang , Chang Zhengwei , Hu Pengchao , Liu Hongli , Li Fuxin , Chen Yumin
Published: April 2024

With the rapid development of urbanization in China, urban energy consumption increases rapidly, leading to energy shortages and environmental pollution, of which building operational energy consumption carbon emissions (BECCE) account for a large proportion. It has a vital impact on global warming and urban green and sustainable development. Chengdu city in Sichuan Province is taken as the research area in this paper. First, basic information and power data on four types of single buildings, including large-sized buildings, small- and medium-sized buildings, government agencies, and residential buildings, are collected. Second, the characteristics of the four types of buildings are extracted, and the calculation model of BECCE (“electricity-carbon” model) based on particle swarm optimization algorithm–support vector machine (PSO–SVM) is constructed, and the model is trained and verified using the method of five-fold cross-validation. Then, according to the mean absolute error (MAE), root mean square error (RMSE), and R2 evaluation indicators, the constructed “electricity-carbon” model is compared and evaluated. Finally, the generalization ability of the “electricity-carbon” model is verified. The research results show that (1) the “electricity-carbon” model constructed in this paper has a high accuracy rate, and the fitting ability of the PSO–SVM model is significantly better than that of the support vector regression (SVR) model; (2) in the testing stage, the fitting situation of large buildings is the best, and MAE, RMSE, and R2 are 858.7, 1108.6, and 0.91, respectively; and (3) the spatial distribution map of regional BECCE can be quickly obtained using the “electricity-carbon” model constructed in this paper. The “electricity-carbon” model constructed in this paper can provide a scientific reference for building emission reduction.
Old-growth forests in the Dinaric Alps of Bosnia-Herzegovina and Montenegro: a continental hot-spot for research and biodiversity
Authors: Motta Renzo , Alberti Giorgio , Ascoli Davide , Berretti Roberta , Bilic Srdjan , Bono Alessia , Milic Curovic , Vojislav Dukić , Finsinger Walter , Garbarino Matteo , Govedar Zoran , Keren Srdjan , Meloni Fabio , Ruffinatto Flavio , Nola Paola
Published: April 2024

Introduction

According to various censuses, Europe has less than 1.5 million ha of old-growth forests (OGF). Most of them are in the boreal zone, while their presence in the temperate zone is residual and fragmented.In the framework of the EU biodiversity strategy, it has been adopted a broad definition of OGF which includes late-seral forests and forests with some management legacies. However, research purposes need to identify strictly defined OGFs characterized by structure, disturbance history, and processes typical and exclusive of the last stage of the forest dynamic.

Methods

The present paper wants to contribute to this debate by presenting a research network of four mixed (Fagus-Abies-Picea) montane OGFs in the Dinaric Alps (Lom, BiH; Janj, BiH; Perućica, BiH; Biogradska Gora, MNE), summarizing 20 years of multidisciplinary research by focusing on the structural characteristics and the disturbance history of the whole network and their coherency with strict OGF indicators. These sites were selected in relatively structurally uniform study areas, where 142 permanent plots have been established since 2002.

Results and discussion

The study sites have a high living (747–1,201 m3 ha−1) and coarse woody debris (CWD) biomass (304–410 m3 ha−1), resulting in the highest forest carbon sink at the continental level (398–484  Mg C ha−1). The presence of large and old trees is one of the critical characteristics of the old-growth stage: in Lom and Perućica, there are 19 trees and 14  ha−1 larger than 1 m at breast height, respectively, and 14 trees and 15 trees ha−1 older than 400  years. In the last three centuries, continuous small-scale disturbances have driven forest dynamics, developing stands characterized by gap-phase dynamics and quasi-equilibrium structure. The Dinaric OGF network presents robust indicators of old-growthness, similar structural characteristics, and dynamic processes across all four sites. Identifying this sub-set of OGF using strict criteria is critical for recognizing conservation priorities and for quantifying, along an old-growthness chronosequence, the current structural differences of managed or recently abandoned forests. Besides, only OGF selected with rigorous criteria can act as a reliable reference for ecological restoration and sustainable forest management as a benchmark for carbon sink and for quantifying the impact of climate change on forests.