bluuebunny/crossref_metadata_2025 huggingface dataset:
Hyperplastic, dysplastic and neoplastic lesions associated with a model of carcinogenesis induced by DMBA in the salivary glands of BALB-c mice
Authors: S Carino , de LeBlanc A De Moreno , Odstrcil AC Aybar , SE Castillo
Published: October 2024

The aim of this work was to develop a mouse model of submandibular salivary gland carcinogenesis by chemical induction and to perform a revision of the literature on similar models using the carcinogen 7,12-Dimethylbenz[a]anthracene (DMBA). The descriptive review was carried out on published works in English and Spanish languages, from the period 1977-2023, which included different animal models of chemical carcinogenesis induced by DMBA in salivary glands. Articles were reviewed in order to analyze the effectiveness of the carcinogenesis induction. For our model, BALB/c mice were used. Animals were anesthetized and after surgery to expose the submandibular gland, each mouse was injected with solution of DMBA 2% in corn oil. Mice were monitored weekly until sacrifice at week 12. The samples were processed with the routine histological methods. The results from the descriptive review showed that DMBA is mainly administered by Intraglandular injections into the submandibular glands after surgical exposure, being both pellets and solutions used for the induction, and rats more common than mice. This revision summarizes the research results of previous studies and demonstrates which model has greater reproducibility. Our results showed that one single injection of DMBA directly into the surgically exposed submandibular gland was an optimal technique to induce the tumor at the desired site. Edema was observed in the surgical area during the first 2 weeks. From week 5, the mice presented internal hardness and hair loss in the glandular area; 50% of the animals presented palpable and measurable tumor masses from week 10. Microscopic observations showed that 89% of the mice developed malignant neoplasms: Carcinomas in situ, micro-invasive and invasive (6/8); sarcomas (1/8), and carcinosarcoma (1/8). Associated lesions were atypical ductal hyperplasia; periductal fibrosis, and sarcomatous stroma. This model marks a difference with the subcutaneous injection technique, without surgery, which does not allow the carcinogen to be adequately directed to the gland.
Critical Temperature Determination for Simple Fluids: an Analytical Approach Based on Collective Variables Method
Authors: Yukhnovskii I.R. , Romanic R.V.
Published: October 2024

An explicit equation for the liquid-vapor critical temperature of simple fluids is derived within an analytic approach – the method of collective variables with a reference system. This equation is applied to calculate the critical temperature values for several hard-core van der Waals fluids. The study also examines how the critical temperature depends on parameters of the interaction. Specifically, it is observed that, as the range of attractive interaction decreases, the critical temperature decreases as well.
Exploring children's responses during ‘school’ picture book reading for kindergarten-elementary school transition
Authors:   Research Institute for Early Childhood Education - Korea National University of Education, Han Ju-Hui , Kim Ho
Published: October 2024

The purpose of this study is to explore children’s responses during the reading process of ‘school’ picture books for kindergarten-elementary school transition. Data was collected and analyzed from 16 five-year-old children in K kindergarten located in S city, Gyeonggi-do. The research findings are as follows: First, children expressed expectations about the main character's happy and enjoyable school life, related their own experiences to the main character's experiences, and talked about the main character's limitations and difficulties. In addition to empathizing with the protagonist, they responded by presenting opinions different from those of the protagonist. Second, children showed responses that extended beyond empathy and exploration for the protagonist to cooperative relationships surrounding the protagonist. The reaction to the collaborators around the protagonist was interested in the collaborator and responded to delivering his or her story from the perspective of the collaborator. The results of this study are significant in that they focus on children's initiative in the direction and approach of linking kindergarten and primary school and present a discussion on children's independent and active participation in the linking process.
Development and effectiveness of teacher education program to improve parent education competency of infant teachers
Authors:   Research Institute for Early Childhood Education - Korea National University of Education, Ko Youngsil , Kwon Yijeong
Published: October 2024

The purpose of this study is to develop an educational program to enhance the parental education competency of infant teachers so that infant teachers can recognize their role as parental educators and implement parental education in the child care field. To this end, prior research analysis and a demand survey were conducted in the analysis and design stage and 288 teachers in charge of the 2-year-old infant class and 239 parents with 2-year-old children. In the implementation stage, a program (draft) was executed for 10 infant teachers, and in the evaluation stage, the final program was developed by revising and supplementing based on the data collected in the implementation stage. The educational program to enhance the parental education competency of infant teachers aims to enhance the knowledge, skills, and attitudes of teachers, which are the categories of parental education competency of infant teachers, and the educational content was organized by selecting eight topics in connection with the educational goal. Teaching and learning methods are conducted through lectures, field case-oriented discussions, temperament tests, field visits, and role-play activities through cases, and are operated offline for the 8th session (16th session). The results of this study suggest that programs to enhance parental education competency of infant teachers should be actively implemented, and programs that can comprehensively enhance parental education competency are needed.
Improving Hospital-to-Home for Medically Complex Children: Views From Spanish-Speaking Caregivers
Authors: Squires Stephanie S. , Hoang Kim , Grajales Lizette , Halpern-Felsher Bonnie , Sanders Lee
Published: October 2024

BACKGROUND AND OBJECTIVES

Children with medical complexity (CMC) experience increased risk of adverse events during and after hospitalization, and these risks are even greater for CMC whose caregiver has a preferred language other than English. Because many adverse events for CMC may be attributable to communication challenges, understanding caregiver and physician perspectives may help prevent adverse events.

METHODS

We conducted semistructured interviews with Spanish-speaking caregivers of hospitalized CMC and their inpatient attending physicians. Each interview was conducted 24 to 72 hours after hospital discharge. Interviews continued until thematic sufficiency was reached. Interviews were audio recorded, transcribed, and translated verbatim. Investigators independently coded and reconciled codes using constant comparison to develop themes via inductive thematic analysis.

RESULTS

We conducted 28 interviews (14 caregivers, 14 physicians). Three themes were identified: (1) barriers exist in providing language-concordant care in planning for transitions from hospital-to-home; (2) both physicians and caregivers perceived logistical challenges in using interpreters at the point of care; and (3) many caregivers felt uncomfortable asking physicians questions related to their child’s medical management because of their language barrier. Participants also offered strategies to improve the transition from hospital to home: (1) empower families to ask questions and take notes, (2) consider the use of medical educators, and (3) improve the ability of hospital-based physicians to follow up with patients after discharge.

CONCLUSIONS

Physicians strive for language-concordant care at each stage of discharge planning. However, unresolved gaps such as the lack of interpreter availability during medical-device education, require attention to promote safe transitions from hospital to home.
Hogyan mondjam el neked, hogy ne vegyem el a kedvedet? Esszencialista és viselkedésalapú visszajelzések hatása a beosztottak érzelmeire
Authors: Marót Janka Laura , Szabó Zsolt Péter , Török Lilla , Orosz Gábor
Published: October 2024

Háttér és célkitűzések: A vezetők által adott visszajelzések fontos témái a vezetés- és szervezetpszichológiának, mégis viszonylag kevés empirikus jellegű tanulmány jelent meg a témában. Jelen cikk célja, hogy az irodalmi bevezetőben kifejtse a kurrens elméleteket, illetve körüljárja az esszencialista (személyiségre), ill. viselkedésre vonatkozó visszajelzésekkel kapcsolatos eddigi eredményeket. Módszer: Az első tanulmány online kérdőíves módszerrel tárja fel, hogy milyen gyakran kapnak a magyar munkavállalók esszencialista vs. viselkedésalapú visszajelzéseket. A második tanulmányban egy online kísérletben 2 × 2-es elrendezést alkalmaztunk, amelyben a válaszadót arra kértük, hogy képzelje bele magát egy munkahelyi visszajelzéses helyzetbe, ahol a vezető észlelt kompetenciáját és az esszencialista vs. viselkedésalapú visszajelzést manipuláltuk. Kimeneti változóként azt mértük, hogy a válaszadók mennyi negatív érzést említenek saját magukkal és a vezetőjükkel kapcsolatban a visszajelzést követően. Eredmények: Az esszencialista és a viselkedésalapú visszajelzések eltérő érzelmi dinamikát indítanak be: az esszencialista visszajelzések olyan érzelmeket váltanak ki, amelyek a konfliktust vételezik elő a vezető és a beosztottja között, míg a viselkedésalapú visszajelzések olyanokat, amelyek motivációt nyújthatnak a jövőbeli jobb teljesítményhez. A vezető kompetenciája szintén számít: a nem kompetens vezető iránt gyakrabban élnek meg a vizsgálati személyek negatív érzelmeket az üzenet jellegzetességeitől függetlenül, míg a kompetens vezetőtől könnyebben fogadják el a kritikát. Következtetések: A válaszadók megítélése alapján elég valószínű, hogy a magyar szervezetekben gyakoriak az esszencialista visszajelzések, amelyek számos vizsgálat alapján káros motivációs és érzelmi következményekkel járhatnak. A vezető alacsony kompetenciája fokozza az esszencialista visszajelzésekből származó problémákat.
Structure and optical properties laser modification of the Ag-PbSe films.
Authors:   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO, Olkhova Anastasiia A. , Patrikeeva Alina A. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO, Butyaeva Maria A. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO, Omelchenko P.P. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO, Shulga B.G. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO, Sergeev Maksim M. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics University ITMO
Published: October 2024

The modification of the structure and optical properties of two-layer silver-lead selenide (Ag-PbSe) films because of exposure to laser nanosecond pulses of near-infrared radiation in the scanning mode is considered. The formation of micro-sized fragments and silver nanoparticles as a result of laser irradiation, as well as their effect on the spectral transmission and reflection of the film, has been revealed. It is shown that the presence of a silver layer on a PbSe film is an effective way to improve the optical characteristics of the material, which expands the scope of possible applications of chalcogenide films of this composition.
Treatment of hypertension within primary health care in the Kyrgyz Republic: pharmacoepidemiology and control efficiency
Authors: Polupanov A. G. , Narkulova G. O. , Dzhamangulova T. Dzh. , Sabirova A. I. , Bebezov I. Kh. , Kundashev U. K. , Sabirov I. S. , Dzhishambaev E. D. , Dzhumagulova A. S.
Published: October 2024

Aim. To study the pharmacoepidemiological aspects and efficiency of hypertension (HTN) control at the level of primary health care in the Kyrgyz Republic (and their compliance with modern clinical guidelines.

Material and methods. Within the project "Analysis and evaluation of factors determining the control of management of patients with hypertension and other cardiovascular diseases in the Kyrgyz Republic", supported by the Ministry of Health of the Kyrgyz Republic and the Swiss project "Effective management and prevention of non-communicable diseases in Kyrgyzstan", we studied compliance of antihypertensives' prescription with modern clinical guidelines and the effectiveness of HTN control at the level of primary health care in the Kyrgyz Republic. We analyzed the medical records of patients registered with a diagnosis of HTN for 2022. Family doctor groups (FDGs) were used as the Primary Sampling Unit (PSU), which were sampled using probability sampling proportional to the size of the general population. Medical records of patients from FDGs were used as the Secondary Sampling Unit. We selected 40 medical records of patients from each FDG. A total of 3675 medical records of patients with hypertension were studied throughout the Kyrgyz Republic.

Results. The age of patients from the selected 3675 medical records ranged from 19 to 93 years (mean age, 62±9 years). Most of the examined individuals were women (2567 respondents, or 69,9%), while men were represented by 1108 respondents (30,1%). According to the study of medical records, the proportion of individuals with HTN covered by treatment was 86,6% (including 90,3% of women and 84,6% of men, p<0,001), of which 43,8% of patients received monotherapy, 39,4% received dual therapy, 14,4% received triple therapy, and 2,4% of respondents received 4 or more antihypertensive drugs. On average, out of the total number of people receiving antihypertensive drugs, there were 1,76 drugs per patient with hypertension, and this parameter was slightly higher in women (1,83) than in men (1,66). The proportion of effectively treated patients in general among people with HTN was 42,1% (43,5% in women and 35,5% in men, p<0,0001). Hypertension control in the study cohort was 42,1%, and this parameter was also higher in women than in men (44% versus 37,8%, respectively, p<0,001).

Conclusion. The study revealed a high proportion of patients covered by treatment using modern antihypertensive drugs and an increase in the effectiveness of treatment and control of HTN over the past decade in the Kyrgyz Republic.
Changes in the leukocyte component and the role of hematological indices in cardiovascular diseases: focus on surgical myocardial revascularization (literature review)
Authors: Kuzmichkina M. A. , Kaveshnikov V. S.
Published: October 2024

The high prevalence of cardiovascular diseases inevitably entails an increase in the number of annual surgical myocardial revascularization procedures. In this regard, the increasing risk of postoperative complications is obvious. The aim of this work was to analyze the available literature on the study of the systemic inflammatory response (SIR) in cardiovascular diseases with an emphasis on coronary artery bypass grafting (CABG). The study of the mechanisms of SIR after cardiac surgery allowed attempts to suppress the activity of the cytokinin storm. The main significance of leukocytes in the initiation of SIR served as the reason for studying the prognostic value of the leukocyte level, both in the postoperative and preoperative periods. The article reflects data on the role of hematological markers and indices. In addition, the results of studies on the significance of a normal high level of leukocytes in the preoperative period are presented, since a negative prognosis was noted in such a group of people who underwent CABG. While remaining a widely accessible and inexpensive method, the assessment of the leukocyte formula, as well as the calculated hematological indices, acquire predictive value for postoperative complications and outcomes.
Molecules secreted by visceral adipocytes in patients with coronary atherosclerosis and insulin resistance
Authors: Ledovskikh S. R. , Garbuzova E. V. , Shramko V. S. , Kashtanova E. V. , Polonskaya Y. V. , Stakhneva E. M. , Kurguzov A. V. , Chernyavsky A. M. , Ragino Yu. I.
Published: October 2024

Aim. To study the association of adipocytokine levels with insulin resistance (IR) and stable/unstable plaques in patients with coronary atherosclerosis.

Material and methods. This cross-sectional observational study included 109 men aged 38-79 years with class II-III stable angina pectoris without acute coronary syndrome (ACS), with coronary atherosclerosis verified by coronary angiography. Biochemical tests were carried out using the enzymatic method on a Konelab 30i analyzer at the Laboratory of Clinical Biochemical and Hormonal Studies of Internal Diseases of the Research Institute of Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and Genetics. All patients also underwent anthropometric examination.

Results. Patients with coronary atherosclerosis and IR had higher levels of GIP by 1,4 times (p=0,005), GLP-1 by 1,7 times (p=0,032), IL-6 by 3,2 times (p=0,017), leptin by 2,3 times (p=0,001) and pancreatic polypeptide (PP) by 1,9 times (p=0,006). In patients with stable plaques and IR, leptin was 2 times higher, and PP was 1,7 times higher, compared to patients without IR. In patients with unstable plaques and IR, leptin and PP levels are 5,1 and 1,7 times higher, respectively, compared to the group of patients without IR. In patients with IR and stable plaques, PYY was 1,5 times higher than in patients with IR and unstable plaques, while the adiponectin level was 1,9 times higher. Logistic regression analysis demonstrated that PP is associated with IR in patients with unstable plaques.

Conclusion. Patients with coronary atherosclerosis and IR had higher levels of GIP, GLP-1, IL-6, leptin and PP. Leptin and PP levels are higher in patients with both stable and unstable plaques and IR, and PYY and adiponectin levels are higher in patients with stable plaques and IR compared with patients without IR. PP is associated with IR in patients with unstable plaques.
Pulmonary embolism in a patient with viral pneumonia: COVID-19 or H1N1 influenza: two case reports
Authors: Kononov S. K. , Solovev O. V. , Metelev I. S. , Nazarov D. E. , Pshenichnikova A. V. , Khomyakov D. A.
Published: October 2024

The article presents two case reports of pulmonary embolism in patients with viral pneumonia. In one case, in a coronavirus disease 2019 (COVID-19) survivor, while in the second case — in a patient with influenza. A comparative analysis of thromboembolism characteristics in two patients is consistent with the literature data and confirms the differences in its predictors and the different clinical picture. Pulmonary embolism is becoming an increasingly relevant disease for cardiologists. The importance of understanding the risk factors for pulmonary embolism and clinical picture aspects in patients with viral pneumonia in the current epidemiological situation with both a COVID-19 and seasonal pathogens, including the influenza virus, is emphasized.
Endothelium-mediated vasodilation: associations with cardiometabolic diseases and their risk factors in aging
Authors: Ryabikov A. N. , Troshina M. S. , Ryabikov M. N. , Palekhina Yu. Yu. , Butakov E. O. , Malyutina S. K.
Published: October 2024

Aim. To evaluate the association of flow-mediated vasodilation (FMD) with cardiometabolic diseases (CMDs) and their risk factors (RF) in old age.

Material and methods. The study was conducted in the Russian population cohort of the HAPIEE project (Novosibirsk, 2015-2018). Endothelial function was assessed in a random subsample (788 men and women aged 55-84 years) using ultrasound measurements of the brachial artery FMD. Endothelial dysfunction (ED) was recorded with FMD <10%. Cardiovascular diseases (CVD) and risk factors were assessed using standard epidemiological methods.

Results. The incidence of hypertension (HTN) was 78,8% (the same in men and women), major CVDs — 21,7% and 17,1%, type 2 diabetes (T2D) — 18,7% and 19,1% in men and women, respectively. The mean FMD values were 2,7% (SD 7,32) and 3,2% (7,19), while the prevalence of ED was 88,2% and 85,8% in men and women, respectively, and did not differ significantly by sex. Men with ED had higher levels of blood triglycerides (125,1 (71,23) vs 102,7 (45,79) mg/dl; p=0,033), waist/hip circumference indices (0,94 (0,050) vs 0,92 (0,076); p=0,009) and body weight (27,7 (45,79) vs 26,5 (4,36) kg/m2; p=0,077). In women, a tendency towards an association of ED with smoking was revealed (p=0,067). There were no associations of ED with HTN, T2D and CVD in men and women.

Conclusion. The PMD test demonstrated a high incidence of ED in a population sample of 55-84 years old. ED is associated with metabolic risk factors in men and smoking in women. No associations of PMD with CMDs were found, presumably due to the high incidence of ED and cumulative disease in the elderly. Modification of metabolic risk factors and smoking cessation are relevant at any age to prevent the progression of ED.
Lipoprotein(a) as underestimated cardiovascular risk factor in Russia. Time to introduce into clinical practice
Authors: Afanasyeva O. I. , Pokrovsky S. N.
Published: October 2024

An increased concentration of lipoprotein(a) (Lp(a)) is one of the main genetic residual risk factors for atherosclerotic cardiovascular diseases, as well as their complications. Lp(a) is a complex supramolecular complex in which the unique glycosylated apo(a) protein, which has a wide polymorphism, is linked by a disulfide bond to the apoB100 molecule (protein component of the low-density lipoprotein (LDL) particle). Therefore, Lp(a) is often called LDL-like particle. Unlike all other lipoproteins, Lp(a) concentration is determined genetically, almost constant throughout the life, and has wide individual and interethnic variability. As an independent risk factor, elevated Lp(a) concentrations can significantly increase global cardiovascular risk, especially in patients with other risk factors. Modern international and national guidelines recommend measuring Lp(a) concentration not only in certain categories of patients, but also in every person at least once in their life for a correct assessment of cardiovascular risk.
The era of targeted therapy for hyperlipidemia
Authors: Chubykina U. V. , Tyurina A. V. , Ezhov M. V.
Published: October 2024

Despite a variety of lipid-lowering drugs, mostly pelleted, aimed at reducing low-density lipoprotein cholesterol and triglycerides, only a small number of patients achieve their target levels. The reasons are insufficient adherence to treatment, rare use of combined lipid-lowering therapy regimens by attending physicians, low availability and high cost of injected lipid-lowering agents. With the advent of technologies for targeted therapy for hyperlipidemia, a new era in cardiology opens. These innovations will lead to higher goal achievement rates through a personalized and precision approach to hyperlipidemia treatment. Novel lipid-lowering drugs are directed at the molecular targets of hypercholesterolemia, hyperlipoproteinemia(a) and hypertriglyceridemia. The review purpose is to systematize following information about innovative lipid-lowering drugs: mechanism of action, stage of development, effectiveness and safety.
Management of comorbid patients with chronic kidney disease and decline in renal function: a case report
Authors: Listratov A. I. , Kudrjavtseva A. A. , Sokolova A. A. , Napalkov D. A.
Published: October 2024

Chronic kidney disease is one of the most important diseases in comorbid patients with cardiovascular disease. To reduce the risk of cardiovascular and renal complications, such patients should receive renin-angiotensin system inhibitors, statins and sodiumglucose cotransporter 2 inhibitors. However, deterioration of kidney function is still common in these patients, especially in the presence of risk factors. This case illustrates the decline in renal function in a patient with obesity, uncontrolled hypertension, type 2 diabetes and atrial fibrillation. The management strategy for such patients is given.
Using nature-based solutions to improve coastal resilience
Authors: Pontee Nigel , Bassetti Luce
Published: October 2024

As nature-based solutions (NbS) are implemented more widely, it is essential to be clear in the definition of NbS and understand the performance of the various approaches. The focus on this paper is on coastal NbS, which involve using natural features to offer or improve coastal protection while producing additional economic, environmental and social benefits. There is a broad range of solutions, spanning the creation of large expanses of habitats, hybrids of habitats and harder engineered structures, and ecological enhancements of existing infrastructure. The performance of these different approaches varies widely, and not all NbS are low cost or self-maintaining. In many instances, the capacity for sedimentary habitats to self-maintain will depend on sediment availability, a factor that needs to be considered in the whole-life costs of these approaches. The incorporation of habitat components can, however, bring multiple benefits for both nature and people. Implemented correctly, coastal NbS therefore have the potential to be ‘no regret’ solutions in many locations.
A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases
Authors: Stanajic-Petrovic Goran , Keck Mathilde , Barbe Peggy , Urman Apolline , Correia Evelyne , Isnard Pierre , Duong Van Huyen Jean-Paul , Chmeis Khawla , Diarra Sékou Siramakan , Palea Stefano , Theodoro Frederic , Nguyen Anvi-Laëtitia , Castelli Florence , Pruvost Alain , Zhao Wenchao , Mendre Christiane , Mouillac Bernard , Bienaimé Frank , Robin Philippe , Kessler Pascal , Llorens-Cortes Catherine , Servent Denis , Nozach Hervé , Maillère Bernard , Guo Dong , Truillet Charles , Gilles Nicolas
Published: October 2024

Key Points

MQ232, a disulfide-bond reticulated peptide derived from a natural snake toxin, was optimized as a new aquaretic drug candidate.

MQ232 showed very low acute and chronic toxicity in rat and a biodistribution in mice strongly in favor of the kidney organs.

MQ232 induced a sole aquaretic effect and demonstrated high in vivo activities on hyponatremia and polycystic kidney disease models.

Background

Vaptans were developed at the end of the previous century as vasopressin type 2 receptor antagonists. Tolvaptan is the most prescribed vaptan for hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). However, its use is not as widespread as it should be due to price issues, a narrow therapeutic window, and some side effects. With the aim of discovering new efficient and safer vasopressin type 2 receptor antagonists, we screened animal venoms and identified several peptide toxins. Among them, mambaquaretin 1 (MQ1) displayed unique biological properties in that regard that it was the starting point for the development of a potential drug candidate.

Methods

Human T-cell assays and bioinformatics were used to mitigate MQ1 immunogenicity risk. MQ232 biodistribution in mice was performed by positron emission tomography. Pharmacodynamics, pharmacokinetics, and acute and chronic toxicity tests were performed on control rats. A rat experimental model of desmopressin-induced hyponatremia, ex vivo mice model of kidney cysts, and mice orthologous model of ADPKD were used to validate MQ232 efficacy in these pathologies.

Results

Three mutations were introduced in MQ1 to mitigate its immunogenicity risk. A fourth gain-of-function mutation was added to generate MQ232. MQ232's safety was demonstrated by a first toxic dose as high as 3000 nmol/kg and a strong kidney organ selectivity by positron emission tomography imaging, while showing almost no interaction with the liver. MQ232's efficacy was first demonstrated with an effective dose of 3 nmol/kg in a hyponatremic model and then in polycystic kidney models, on which MQ232 significantly reduced cyst growth.

Conclusions

We demonstrated, using diverse translational techniques and minimizing animal use, MQ232's safety and efficacy in several rodent models of hyponatremia and ADPKD.
FISIOTERAPIA ESPORTIVA: MAPEAMENTO DAS REGIÕES DE LESÕES OCORRIDAS EM PARTICIPANTES DE CROSSFIT REGULARMENTE VINCULADOS A DOIS BOXES NA CIDADE DE FOZ DO IGUAÇU/PR
Authors: Da Silva Oliveira Lucas , Djanilda Parra da Luz Larissa , Azuma Ricardo Henrique Esquivel , Da Luz Nunes Douglas
Published: October 2024

Introdução: O Crossfit é uma sessão de treinamentos lançada para beneficiar o condicionamento físico geral e auxiliar na melhora da saúde. A prática dessa modalidade envolve a realização de alguns exercícios que, se realizados de forma incorreta, podem gerar lesões musculoesqueléticas. A fisioterapia esportiva tem como o objetivo o reparo da saúde funcional do atleta para a prática esportiva. Objetivo: Mapear as lesões mais frequentes relacionadas aos perfis dos praticantes de crossfit regularmente vinculados a dois boxes na cidade de Foz do Iguaçu/PR. Métodos: Trata-se de um estudo observacional, transversal e quantitativo realizado em dois boxes de Crossfit localizadas na cidade de Foz do Iguaçu/PR. Na presente pesquisa foram utilizados dois questionários unificados, que tem como objetivo observar os perfis dos atletas, os tipos de lesões e locais lesionados por conta da prática esportiva.  Resultados: Foi realizado o mapeamento das lesões mais frequentes relacionados aos perfis dos praticantes de dois boxes de alto desempenho físico, Crossfit, sendo assim proporcionando uma idealização do que pode ser feito para evitar as lesões em atletas regularmente vinculados nessas academias. Observou-se que a maioria das pessoas acometidas por lesões eram do sexo feminino e frequentavam o Crossfit Vila A. Conclusão: Este estudo permitiu analisar a frequencia e os locais das lesões físicas que acometem os atletas que praticam crossfit no município de Foz do Iguaçu. Por fim, destaca-se que este trabalho possui limitações, tendo em vista que foi realizado em uma realidade sociodemográfica, cultural e econômica.
Insecticidal efficacy of local diatomaceous earth compositions with different particle sizes against stored grain pests
Authors: Henteş Songül , Işıkber Ali Arda
Published: October 2024

In this study, the efficacy of a mixture of local diatomaceous earth (DE) with different diatomite compositions and particle sizes against stored-grain pests, Sitophilus oryzae L., 1763 (Coleoptera: Curculionidae), Tribolium confusum du Val, 1863 (Coleoptera: Tenebrionidae), and Rhyzopertha dominica (F., 1792) (Coleoptera: Bostrichidae) adults was investigated in 2023 in the Entomology Laboratory of the Department of Plant Protection, Faculty of Agriculture, KSU. In biological tests, 500 and 1000 ppm concentrations (mg DE/kg wheat) of different particle sizes (≤ 20, 20-75, 75-150, and ≥ 150 µm) of DE mixture and original DE (≤ 250 µm) were applied to wheat. The highest mortality rate for all insect species tested at 500 ppm was obtained from DE treatments of ≤20 µm. At 1000 ppm, 100% mortality was observed for T. confusum and S. oryzae in almost all particle size DE-treatments, whereas no local DE treatments resulted in 100% mortality for R. dominica adults. Moreover, the greatest reduction in the number of F1 generation adults for S. oryzae and R. dominica was obtained in the DE treatment of ≤20 µm at 500 and 1000 ppm. In conclusion, local DE mixture treatments with ≤ 20 µm particle size were found to be highly effective in the control of stored-grain pests.
BREAST MILK HORMONES AS RISK FACTORS OR PROTECTORS OF CHILDHOOD OBESITY
Authors: Filipchuk Anatoliy , Dzhumagaziev Anvar , Otto Natalya , Bezrukova Dina , Sosinovskaya Ekaterina , Anisimova Ol'ga
Published: October 2024

The current data on the role of breast milk hormones in the development of obesity in children are summarized. Based on the analysis of domestic and foreign special scientific and practical literature on the databases PubMed, Scopus, Elsevier, eLibrary, information on the genetic basis of the development of obesity is considered. Based on the results of the systematization of the information received, the question was raised about the need for further research in this area due to the relevance of the problems being discussed.
PHYSIOTHERAPEUTIC METHODS IN THE COMPLEX TREATMENT AND REHABILITATION OF PATIENTS WITH CHRONIC PANCREATITIS
Authors: Antonyan Vitalina , Sikorskaya Yuliya , Antonyan Viktoriya , Zakaryaeva Elvira , Radwan Leyla
Published: October 2024

The article analyzes the effectiveness of therapy for patients with chronic pancreatitis with the introduction of physiotherapeutic methods into the complex of measures. The study included 250 patients aged 28 to 67 years diagnosed with chronic pancreatitis. In the main group, patients received an additional course of physiotherapy treatment in addition to standard therapy. In the control group, treatment was carried out according to standards in accordance with clinical recommendations. The obtained results of the study showed that the inclusion of physiotherapeutic methods in the complex therapy of patients with chronic pancreatitis contributes to the complete relief or weakening of pain, a reduction in the period of pain relief, dyspepsia, and helps improve the exocrine function of the pancreas.
Legal Support for Digital Transformation of Local Self‐Government in the Russian Federation: Problems and Prospects
Authors:   Russian Presidential Academy of National Economy and Public Administration, Lipchanskaya M. A. ,   Russian State University of Justice, Channov S. E. ,   Saratov State Law Academy,   Saratov Chernyshevsky State University
Published: October 2024

Introduction: the article analyzes legal support accompanying the transformation of local self‐government, identifies the legal, social, and technological problems of the changes. Currently, digital transformation in state and municipal administration not only makes it possible to adapt the process of interaction between citizens and authorities but also leads to changes in all areas of activity of local administration, to improvement of municipal services as well as to transformation of the rules and work culture of municipal employees. Consideration of the problem of legal support for digital transformation of municipalities is directly related to finding solutions for the development of municipal governance in Russia in general. That is why this problem is of particular relevance today. Purpose: basing on an analysis of legal regulation of local self‐government digitalization, to identify the main trends and problems that influences not only the implementation of digitalization at the local level but also the quality and uniformity of legal regulation of these processes. Methods: the study employed empirical methods of comparison, description as well as special scientific methods: legal‐dogmatic, method of interpretation of legal norms, comparative‐ legal, and systemic. Results: the authors have identified current problems in legal regulation and implementation of digital transformation of local self‐government and developed proposals aiming to alleviate them. Conclusions: the specific nature of local self‐government requires special approaches to digitalization at the municipal level. First of all, digital inequality of both municipalities and their residents should be taken into account. Another feature is that local self‐government is characterized by proximity to the population, which makes it possible to use electronic forms of direct democracy much more widely than at the level of state authority. Finally, the diversity of municipalities requires legal formalization of uniform requirements with regard to infrastructure and software used in municipal governance at the regional level.
Arctic BRICS: Institutional and Legal Dimension of Interaction between Russia and Non‐ Arctic States in the Arctic
Authors:   Odintsovo Branch of MGIMO University, Kotlova A. V. , Vereina L. V. ,   MGIMO University
Published: October 2024

Introduction: the article examines the institutional and legal foundations of interaction between Russia and non‐Arctic states in the Arctic in the new geopolitical context. In connection with the changing nature of the interaction of the Arctic states within the framework of the Arctic Council, the Barents Euro‐ Arctic Council, it seems justified to develop a new institutional architecture for the interaction of states in the polar region. Purpose: to define new institutional and legal foundations of interaction between Russia and non‐Arctic states in the Arctic. The authors analyze the legal possibilities of using the BRICS format for cooperation among states in the Arctic region. Methods: general scientific methods of analysis, synthesis, interpretation, formal logic; methods of historical‐and‐legal analysis, formal‐legal analysis, and legal modeling. Results: an analysis of the existing institutional and legal framework underlying the functioning of the BRICS confirmed the possibility of creating new areas of cooperation, including cooperation in the Arctic region, subject to the adoption of a Declaration on the establishment of an Arctic cooperation mechanism. On the basis of national and international legal acts studied, the authors make a conclusion about the involvement of non‐Arctic states in the Arctic agenda. States that are geographically remote from the Arctic region adopt strategic documents reflecting their intentions to participate in activities in the northern latitudes.
“Government – science – education – business”: Strategic partnership for the purposes of human capital support and economic development
Authors:   Academy of Labor and Social Relations, Ilina Anastasia A.
Published: October 2024

Introduction: human capital, the level of support for which directly affects the development of national and global economies, is a multifaceted concept that requires close attention from the main economic agents – government, science, education and business, as well as their unification when facing the problem of increasing human resources potential under conditions of external environment instability. Objectives: to proposal of economic agents role model in the interests of maintaining their long-term economic, educational and technological cooperation. Methods: logical method, system method, economic analysis, graphical modeling. Results: the need to identify the educational element in the “triple helix” concept and its modifications has been justified. The author’s role model for government, science, education and business is graphically presented in the context of partnerships under modern conditions; a corresponding matrix of competencies has been compiled based on eight parameters grouped into two broad areas. Systematization of coordination problems in “government – science – education – business” partnership within the Russian economy made it possible to identify key areas of cooperation in the form of an updated graphic role model and an adjusted matrix of economic agents competencies. Further prospects for research in the area under consideration are noted. Conclusions: a new format of functions within the framework of a role model, development of feedback channels as a tool for partner communications and satisfying the interests of partners because of resource exchange will allow to keep up a decent level of human capital in the Russian economy, improving its quality and increasing the innovative activity of scientific and educational organizations.
Políticas regresivas de equidad para el acceso a la universidad pública. Un estudio de caso en la Universidad de Caldas (Colombia)
Authors: Rivera Sánchez Bernardo
Published: October 2024

Desde hace tres décadas, la Universidad de Caldas, una universidad pública de orden nacional, promueve políticas compensatorias para acortar la brecha de inequidad en el acceso, al ofrecer cupos especiales a poblaciones vulnerables. El análisis de la progresividad o regresividad de la política emanada del Consejo Académico sobre la equidad en el acceso es el objeto de la investigación realizada. Como estrategia, utilizamos el estudio de caso de la aplicación del Acuerdo 05 de 2017. Para tal efecto, se analizaron 4.105 aspirantes a 20 programas académicos presenciales en la convocatoria 2017-2, de los cuales 891 (21 %) se registraron como especiales, por pertenecer a grupos poblacionales reconocidos como particularmente vulnerables. El número de estudiantes admitidos pertenecientes a grupos poblacionales especiales se redujo con la política compensatoria, lo cual expresa su regresividad. Lo más grave de ello, es la discriminación de aspirantes especiales que alcanzaron un puntaje suficiente para ingresar y no fueron admitidos en razón a que el número de cupos especiales ya había sido cubierto. Los resultados se analizan a la luz de la responsabilidad social de la Universidad y del goce de su autonomía. Se discute el desafío de inclusión para el sistema universitario estatal por el criterio meritocrático con que aplica las pruebas de admisión.
Population consequences of the competition of variable individuals under various of resource dynamics
Authors: Uchmański Janusz
Published: October 2024

Individual-based model of the dynamics of population with non-overlapping generation and explicitly introduced resources which are unequal partitioned  between competing individuals is analysed. It is investigated how individual variability in assimilation of different kinds of resources influences population dynamics. Following kinds of resources are considered: unlimited resources with linear or exponential growth and limited resources growing logistically or with seasonal dynamics. When resources are unlimited population dynamics exhibits oscillations of number of individuals and resources which sooner or later end in extinction of the population. An increase of individual variability increases extinction time. Population dynamics is different when resources growth is limited. Number of individuals in the population initially increases until a certain level is reached, then fluctuates around that level. However, still greater individual variability guarantees greater persistence of the population, especially in rich environments.
Synthesis of RN277 and RN341 v1
Authors: D. Raig Nicolai , Knapp Stefan
Published: October 2024

This protocol outlines the synthesis of the LRRK2-selective type-2 kinase inhibitors RN277 and RN341, including structural characterization using nuclear magnetic resonance (NMR) and mass spectrometry (MS).
Assessment of mouse motor behaviour via open field test, narrowing beam assay, inverted wire hang, and gait analysis v1
Authors: Michael Coughlin Gerard
Published: October 2024

This protocol describes methods for assessment of mouse motor behaviour with 3 separate behavioural tasks: the open field test, the narrowing beam assay, and the inverted wire hang. The open field test measures an animals total locomotor behaviour, but can be confounded by stress and anxiety. The narrowing beam test provides a measure of skilled motor behaviour. The inverted wire hang measures limb strength and endurance. Some or all of these behavioural assays may be used, depending on experimental question.
Mouse EEG implantation and monitoring v1
Authors: Michael Coughlin Gerard
Published: October 2024

Monitoring cortical EEG is an efficient means of identifying and quantifying epileptiform activity in mouse models, especially in cases where behavioural correlates of seizures are subtle (e.g. absence seizures). This protocol describes EEG implantation surgery and EEG data collection for mouse models.
Endometrioma v1
Authors: Ioannidou Alexandra , Machairiotis Nikolaos , Stavros Sofoklis , Potiris Anastasios , Karampitsakos Theodoros , Pantelis Athanasios , Drakakis Petros
Published: October 2024

Background:Endometriosis is characterized by the presence of endometrial tissue outsidethe uterus. Beyond medical treatment, surgical intervention is also a viableconsideration. However, current guidelines do not clearly indicate whetherlaparoscopic cystectomy, ablative methods (CO2 laser vaporization, plasmaenergy), or sclerotherapy is the preferred option. Methods: We conductedsearches in two databases (PubMed, Europe PMC) to retrieve articles containingthe keywords ‘surgical intervention for Endometrioma, ovarian reserve,pregnancy rates, fertility’, published between January 1, 2000, and December31, 2023. We will include articles presenting information on surgical interventionfor endometrioma and its correlation with infertility parameters. Articlesdescribing conservative treatment will be excluded. Data will be extracted by twoauthors using predefined criteria.
GenFS Metadata Cleanup Challenge protocol v2
Authors: Timme Ruth , Shumway Martin , Hope Bias Candace , Balkey Maria , Pfefer Tina
Published: October 2024

This protocol provides guidance for submitting bulk BioSample updates to NCBI for the GenFS Metadata Cleanup Challenge exercise. Table of Contents: Timeline/Workflow for the 2024 Metadata Cleanup Challenge Preparing the update file Making corrections and updates within the file Submitting the finalized template
GenFS Metadata Cleanup Challenge protocol v2
Authors: Timme Ruth , Shumway Martin , Hope Bias Candace , Balkey Maria , Pfefer Tina
Published: October 2024

This protocol provides guidance for submitting bulk BioSample updates to NCBI for the GenFS Metadata Cleanup Challenge exercise. Table of Contents: Timeline/Workflow for the 2024 Metadata Cleanup Challenge Preparing the update file Making corrections and updates within the file Submitting the finalized template Version History: V3: minor edits made to correct typos. Addition of final step to email FDA and NCBI when you've completed all the steps.
EDUCAÇÃO, CIDADANIA E AUTORIZAÇAO EM CONTEXTO DE REGULAÇÃO SOCIAL
Authors: VIANA HELIO FERNANDES , RIBEIRO MAYRA FERNANDES
Published: October 2024

Este artigo decorre de pesquisa bibliográfica e diálogos gerados no âmbito do programa de Pós-graduação em Educação (POSEDUC-UERN). Tem como objetivo refletir em torno às noções de autorização e autor-cidadão a partir de uma epistemologia fundada na multirreferencialidade. Destaca-se a potencialidade dessas noções para pensar a situação do sujeito moderno diante do cenário institucional regulatório já diagnosticado pela crítica social. Todavia, o trabalho sugere que o sujeito não se limita a um ser nulo e que o exercício da escrita política de si constitui potência pedagógica autopoiética para a auto-afirmação do autor-cidadão.
Palavras chaves: Educação. Cidadania. Diário de pesquisa. Autorização
METODOLOGIAS ATIVAS DA PROBLEMATIZAÇÃO NA EDUCAÇÃO BÁSICA: UM ESTADO DO CONHECIMENTO NO CONTEXTO DOS ANOS FINAIS DO ENSINO FUNDAMENTAL
Authors: Jovane Nascimento Thiago , Regina de Souza Fernandes Sônia
Published: October 2024

RESUMO: Este artigo é resultante de uma pesquisa do tipo estado do conhecimento sobre metodologias ativas, no âmbito dos anos finais do ensino fundamental. Partimos da conceituação de estado do conhecimento postulada por Romanowski e Ens (2006), e do percurso metodológico caracterizado por Morosini; Kohls-Santos e Bittencourt (2021). Este estudo teve como corpus analítico 42 pesquisas: 34 dissertações e 8 teses. A exploração do corpus se deu a partir de 13 dimensões, e a análise foi realizada à luz de Bardin (2016). As metodologias mais recorrentes são da problematização, encontradas em 23 pesquisas, cujas análises e descrições trazemos neste artigo. Evidenciou-se que a maior parte das pesquisas são oriundas da prática docente do pesquisador, que é professor da educação básica. Os resultados desta investigação visam integrar os debates acerca das metodologias ativas, a partir de um balanço da produção acadêmica, constituindo-se em ponto de partida para estudos vindouros.