bluuebunny/crossref_metadata_2025 huggingface dataset:
Melt-rock interaction in the lower crust based on silicate melt inclusions in mafic garnet granulite xenoliths, Bakony–Balaton Highland
Authors: Németh Blanka , Török Kálmán , Bali Enikő , Zajacz Zoltán , Fodor László , Szabó Csaba
Published: August 2021

Major and trace element composition of silicate melt inclusions (SMI) and their rock-forming minerals were studied in mafic garnet granulite xenoliths from the Bakony–Balaton Highland Volcanic Field (Western-Hungary). Primary SMIs occur in clinopyroxene and plagioclase in the plagioclase-rich domains of mafic garnet granulites and in ilmenite in the vicinity of these domains in the wall rock. Based on major and trace elements, we demonstrated that the SMIs have no connection with the xenolith-hosting alkaline basalt as they have rhyodacitic composition with a distinct REE pattern, negative Sr anomaly, and HFSE depletion. The trace element characteristics suggest that the clinopyroxene hosted SMIs are the closest representation of the original melt percolated in the lower crust. In contrast, the plagioclase and ilmenite hosted SMIs are products of interaction between the silicic melt and the wall rock garnet granulite. A further product of this interaction is the clinopyroxene–ilmenite±plagioclase symplectite. Textural observations and mass ­balance calculations reveal that the reaction between titanite and the silicate melt led to the formation of these assemblages. We propose that a tectonic mélange of metapelites and (MOR-related) metabasalts partially melted at 0.3–0.5 GPa to form a dacitic–rhyodacitic melt leaving behind a garnet-free, plagioclase+clinopyroxene+orthopyroxene+ilmenite residuum. The composition of the SMIs (both major and trace elements) is similar to those from the middle Miocene calc-alkaline magmas, widely known from the northern Pannonian Basin (Börzsöny and Visegrád Mts., Cserhát and Mátra volcanic areas and Central Slovakian VF), but the SMIs are probably the result of a later, local process. The study of these SMIs also highlights how crustal contamination changes magma compositions during asthenospheric Miocene ascent.
Analisi Data Tersensor Berpasangan dengan Estimasi Kaplan Meier dan Nelson Aalen
Authors: Hikmah Hikmah , Ekawati Darma
Published: August 2021

Dalam bidang matematika, terdapat cabang statistika yang telah mengalami perkembangan yang sangat pesat, salah satunya adalah analisis kelangsungan hidup (survival). Masalah yang sering ditemui dalam analisis survival adalah adanya pengamatan yang tidak lengkap karena terdapat unit penelitian yang sampai akhir pengamatan tidak diketahui apakah mengalami kejadian atau tidak. Tujuan penelitian ini untuk membandingkan analisis data tersensor berpasangan dengan menggunakan estimasi Kaplan-Meier dan Nelson-Aalen. Kedua estimasi tersebut banyak digunakan dalam statistik nonparametrik. Dari hasil yang diperoleh, kedua estimasi tersebut menyatakan bahwa tidak ada perbedaan yang signifikan antara waktu sembuh pasangan suami istri penderita hipertensi.
Analisis Model Mangsa Pemangsa dengan Fungsi Respon Holling Tipe II dan Adanya Mangsa Sakit
Authors: Fardinah Fardinah , Qadrini Laila , Febrilian Fatimah Meryta
Published: August 2021

Interaksi antara dua populasi yang bersifat mangsa dan pemangsa dapat digambarkan dalam suatu model mangsa pemangsa. Dalam kenyataannya, pemangsa memerlukan waktu untuk berburu dan mengkonsumsi mangsanya yang dapat dinyatakan dalam model fungsi respon Holling Tipe II. Selain itu, dapat pula dijumpai dalam suatu lingkungan adanya populasi mangsa yang sakit yang mengakibatkan kematian karena penyakit tersebut. Penelitian ini bertujuan untuk menganalisis kestabilan model mangsa pemangsa dengan fungsi respon Holling Tipe II yang terdiri dari tiga subpopulasi yaitu mangsa sehat, mangsa sakit dan pemangsa. Jenis kestabilan ditentukan berdasarkan karakteristik nilai eigen yang diperoleh dengan menggunakan kriteria Routh-Hurwitz. Dari penelitian ini diperoleh bahwa tanpa adanya mangsa sakit maka populasi tidak akan pernah eksis sedangkan populasi akan eksis jika ketiga subpopulasi ada dan memenuhi syarat hubungan parameter yang digunakan dalam model tersebut
Prospects for digitalization in Russia
Authors: Rozhkov Evgenij
Published: August 2021

While analyzing the current situation in Russian economy, scientists confirm that our industrial enterprises are not yet ready to compete with world industry leaders in introducing digitalization into production. In the course of digitalization implementation, the state prioritizes the development of "smart" cities, though in modern economy, the implementation of Smart City development programs is feasible only in large agglomerations. 
In the context of digitalization, regional economies are unable to support the proper level of development of municipalities with less than two hundred inhabitants, to comply with new standards. Undoubtedly, this actualizes the need to study the digitalization processes in our country. The analysis and synthesis of Russian scientists’ works suggests that the main problem associated with digitalization is the lack of funding for the programs. At the level of enterprises, there is a lack of investment, and at the level of municipalities - a lack of financing from federal and regional budgets.
Social environment for activating economic growth
Authors: Ivanova L.
Published: August 2021

The article analyses the present state of Russian society in the context of overcoming economic stagnation and activating the mechanism of economic growth. The author examines the possibility of mobilizing human capital; social attitudes and their dynamics; the institutional structure of Russian society, implicating the principles of solidarity and coordination of interests within the framework of various voluntary unions and associations. 
The analysis allows the author to define the social conditions for the activation of economic growth as complex, ambiguous and requiring a significant adjustment of social policy. At the same time, there are certain manifestations of Russian society’s interest in self-development, consolidation, and more active socio-economic transformations.
The social demand for progressive sustainable economic development being obvious, the government will be able to launch economic growth by shifting from a policy of social protection to a policy of social development, with adequate goodwill and flexibility.
Rural infrastructure development, based on public-private and municipal-private partnership
Authors: Gritcenko G.
Published: August 2021

The article highlights the interaction of elements of the engineering infrastructure in rural areas; the priority importance of the engineering infrastructure is shown; the es-sence of public-private and municipal-private partnerships and the principles of inter-action between participants in innovative projects are outlined; the advantages of us-ing PPP mechanisms and the main problems of businesses participating in PPP pro-jects are disclosed.
Explaining "-splain" in digital discourse
Authors: Bridges Judith
Published: August 2021

Combining digital discourse analysis and Citizen Sociolinguistics, methodological frames that contend with the effects of evolving digital practices, I present an approach to studying sociolinguistic trends by investigating how social media users talk about what language is doing.

This approach is applicable to research on a wide range of linguistic and cultural contexts. The particular focus in this paper, however, is on U.S.-based social issues and linguistic features of American English as they appear in pieces of digital discourse from the micro-blogging platforms Twitter and Tumblr. Situated within the highly fractured sociopolitical climate of the pandemic-afflicted United States, the language under discussion provides a glimpse of some historically relevant sociocultural beliefs and attitudes towards the role of gender and racial identity in sociopolitical discourse. Focusing on uses of -splain, a metapragmatic bound morpheme, the paper demonstrates how social media users assemble lexical, discursive, and other semiotic resources as means for negotiating sociopragmatic appropriateness. The analysis shows how the usage of words like mansplain encompass the sociolinguistic process of enregisterment through practices of linguistic reflexivity, creativity, and regimentation – practices that are essential aspects of interaction and participation in social media. Using these enregistered metapragmatic words problematizes imbalances in users’ sociopragmatic ideologies, namely who can or cannot say what, to whom, and in what manner. I show how creative metapragmatic language is deployed to discuss issues of entitlement and epistemic authority in communicative dynamics. I draw on theoretical frames that reveal how the recontextualization and resemiotization of -splain words and other metapragmatic neologisms are performances of identity. I also show how splain-mediated communication facilitates users in achieving their own discursive intentions to point out language in judgmental and/or lighthearted manners. I assert that attention to metapragmatic neologisms in the perspective of Citizen Sociolinguistics enhances the analytical repertoire of digital discourse analysis.
PRODUKTIFITAS LEBAH Trigona sp. PADA BERBAGAI TEKNIK BUDIDAYA DI DESA NAYAGATI KECAMATAN LEUWIDAMAR KABUPATEN LEBAK
Authors: Setiawan Anang , Susdiyanti Tun , Meiganati Kustin Bintani
Published: August 2021

Non-Timber Forest Products (HHBK) have been used by communities around the forest. Apart from being easy to obtain and not requiring complicated technology to get it, it also has high economic value. It is believed that the existence of NTFPs is most closely related to the interests of the community, especially the people living around the forest, in fulfilling their daily needs. One of the NTFPs products is honey bee which has high economic and utility value. This study aims to determine the bee cultivation technique of Trigona sp. which produces the highest hive weight and bee product. This research is located in Bulakan Village, Nayagati Village, Leuwidamar District, Lebak Regency. The research was conducted for 3 (three) months from August to December 2019. The research method was by observing the weight of the hive and yield of bee products, and analyzed descriptively. The results showed that the bee cultivation technique that produced the highest productivity in terms of hive weight yield, honey, propolis and brood bee was the cage technique, and the factors that caused differences in productivity were the source of feed and the presence of predators. In the cultivation of bees Trigona sp. The source of feed is very important, besides the need for monitoring every day to avoid predators.
Perbandingan Kinerja Bank Pembiayaan Rakyat Syariah dan Bank Perkreditan Rakyat di Indonesia
Authors: Aliefah Aniesatun Nurul , Renfiana Lilis
Published: August 2021

The purpose of this study is to compare the performance of The Conventional Rural Bank (BPR) and Islamic Rural Bank (BPRS) in Indonesia using the REC method which consists of a risk profile, earnings, and capital during the 2015-2017 period. The risk profile factor is represented by the NPF indicator, income is represented by ROA and capital is represented by CAR. By using the purposive sampling method, as many as 43 Islamic Rural Bank (BPRS) and 63 Conventional Rural Bank (BPR) were obtained from secondary data sourced from annual financial reports published on the bank's official website. The analysis technique was then carried out using the Mann-Whitney-U test to compare the performance of the two banks. The results of this study indicate that there is a significant difference in NPF between the two banks at a significance level of 0.006; There is no significant difference in ROA and CAR between Islamic general financing banks and rural credit banks in Indonesia at the ROA significance level of 0.070 and CAR 0.239, respectively. The implication of this research implies that the performance of Islamic BPRs still has a great opportunity to develop in the future and is a big challenge, especially for the management of Indonesian Islamic BPRs and the central bank (Bank Indonesia) as a bank. regulators.
Narrative der Essstörung im zeitgenössischen Film und Roman. Simón Bross' Malos hábitos (2007) und Nina Bouraouis La voyeuse interdite (1991)
Authors: Jacobi Claudia
Published: August 2021

En el cine contemporáneo y en la literatura narrativa de los países de lengua románica se encuentra una multitud de obras en las cuales los trastornos alimenticios no sólo representan una adecuación exagerada a los dictados contemporáneos de
belleza, sino también una metáfora sociocultural que visualiza las disfunciones de la sociedad actual a través del cuerpo femenino. El análisis de la película Malos hábitos (2007) del director mejicano Simón Bross y de la novela La
voyeuse interdite (1991) de la autora franco-argelina Nina Bou- raoui demuestra que la sumisión del cuerpo femenino a los ideales desinhibidos de belleza occidental (Bross) y a las normas púdicas de un Islam fundamentalista (Bouraoui) representan la dependencia de la mujer
con respecto al poder de la mirada masculina (male gaze), transformando el cuerpo femenino en un espacio de proyección de las jerarquías sociales . Ante la idea ampliamente difundida del Islam como ’lo otro‘, criticado particularmente por su ’concepción
atrasada‘ en cuanto al papel de la mujer, la comparación demuestra que la hipersexualización occidental y la tabuización integrista del cuerpo femenino son dos caras de la misma moneda, que reduce a la mujer – de manera desconcertantemente similar – al
estado de objeto sexual.
’Nur über ihre Leiche‘? Aspekte der Fantastik in Javier Marías' Corazón tan blanco und Mañana en la batalla piensa en mí: Eine Lektüre mit Julio Cortázar
Authors: Jünke Claudia
Published: August 2021

La contribución explora la dimensión fantástica de dos novelas de Javier Marías, Corazón tan blanco (1992) y Mañana en la batalla piensa en mí (1994), basándose en las reflexiones de Julio Cortázar sobre lo
fantástico en Hispanoamérica . Bien es verdad que las dos novelas mencionadas no forman parte de la literatura fantástica en un sentido estricto; no obstante se sirven de temas, motivos y estrategias narrativas características de este tipo de ficción . Utilizando
los modelos de la ’constelación instantánea‘ (Cortázar) y de la ’pareja espantosa‘ (Marías), el artículo muestra que en ambas novelas las transgresiones fantásticas corresponden a transgresiones en el ámbito de las relaciones
entre el género masculino y el femenino . La super-vivencia y estabilidad de los hombres están vinculadas con la muerte de las mujeres – la autoafirmación de los protagonistas masculinos solo es posible ’sobre su cadáver‘ (E . Bronfen) .
Quality and usability of clinical assessments of static standing and sitting posture: A systematic review
Authors: Woldendorp Kees H. , Kleinbergen Jonas F.E. , Boonstra Anne M. , de Schipper Antoine W. , Arendzen J. Hans , Reneman Michiel F.
Published: August 2021

BACKGROUND: A validated method to assess sitting and standing posture in a clinical setting is needed to guide diagnosis, treatment and evaluation of these postures. At present, no systematic overview of assessment methods, their clinimetric properties, and usability is available. OBJECTIVE: The objective of this study was to provide such an overview and to interpret the results for clinical practice. METHODS: A systematic literature review was performed according to international guidelines. Two independent reviewers assessed risk of bias, clinimetric values of the assessment methods, and their usability. Quality of evidence and strength of recommendations were determined according to the Grading of Recommendations Assessment, Development and Evaluation working group (GRADE). RESULTS: Out of 27,680 records, 41 eligible studies were included. Thirty-two assessment instruments were identified, clustered into five categories. The methodological quality of 27 (66%) of the articles was moderate to good. Reliability was most frequently studied. Little information was found about validity and none about responsiveness. CONCLUSIONS: Based on a moderate level of evidence, a tentative recommendation can be made to use a direct visual observation method with global posture recorded by a trained observer applying a rating scale.
High expression of PPM1G is associated with the progression and poor prognosis of hepatocellular carcinoma
Authors: Xiong Dan-Lei , Li Qian , Wang Heng , Jin Wei-Li , Fan Xiao-Ming , Ma Ying-Yu
Published: August 2021

BACKGROUND: PPM1G, a member of the serine/threonine protease family, dephosphorylates various proteins and may be involved in cancer development. The role and mechanism of PPM1G in HCC still needs to be verified. OBJECTIVE: This study aims to explore the role of PPM1G in the occurrence, development and prognosis of HCC. METHODS: Using bioinformatics (UALCAN, cBioPortal, Linkedomics, STRING and GSEA) to analyze the expression of PPM1G mRNA in HCC, its clinical relevance and possible involved signaling pathways. The expression of PPM1G protein was determined by immunohistochemistry in 311 cases of HCC to evaluate the association between PPM1G and clinical features and prognosis. RESULTS: The expression of PPM1G was significantly upregulated in HCC (P< 0.001), correlated with the metastasis (P= 0.020), pathological grade of HCC (P= 0.032), microvascular invasion (P= 0.040), and HBV infection (P= 0.041). Cox multivariate regression showed high expression of PPM1G was an independent prognostic factor for HCC. Its role in HCC may relate to methylation and frequency mutation. Furthermore, the database showed PPM1G is involved in the signal pathway such as cell cycle, WNT pathway, and mTOR pathway in HCC. CONCLUSION: PPM1G showed an essential function involving in tumor-related pathways in HCC, providing a biological basis for targeted treatment of HCC clinically.
A systematic approach introduced novel targets in rectal cancer by considering miRNA/mRNA interactions in response to radiotherapy
Authors: Khalighfard Solmaz , Kalhori Mohammad Reza , Amiriani Taghi , Poorkhani Amirhoushang , Khori Vahid , Esmati Ebrahim , Lashkari Marzieh , Najafi Ali , Alizadeh Ali Mohammad
Published: August 2021

BACKGROUND: The discovery of miRNA/mRNA interactions in several biological samples prompted the researchers to explore new biomarkers in tumors. OBJECTIVE: We aimed to investigate the interactions of miRNA/mRNA in response to radiotherapy in the plasma samples of rectal cancer patients. METHODS: Five microarray datasets related to cancerous and non-cancerous individuals were first used to construct networks. The databases of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied to analyze pathway enrichment. The plasma samples were then collected from 55 patients with recently diagnosed rectal cancer and 10 healthy subjects. For radiotherapy courses, the patients have consecutively received 30 sessions of local radiation for six weeks. At last, the expression of selected genes and miRNAs was experimentally measured before and after radiotherapy by qPCR, and the protein levels of the target genes were measured by ELISA assay. We evaluated the therapeutic responses based on the tumor regression grade of the Dworak classification. RESULTS: We identified 5 up-regulated and 5 down-regulated miRNAs and 8 up-regulated and 3 down-regulated genes of the databases. There was a significant increase in tumor suppressor miRNAs, including miR-101-3p, miR-145-5p, miR-26a-5p, miR-34a-5p, and a significant decrease in oncomiRs, including miR-221-3p and miR-17-5p, after radiotherapy compared to the pre-treatment. Moreover, the up-regulated miR-17-5p and miR-221-5p and the down-regulated miR-101-3p and miR-145-5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-β signaling pathways. An analysis of receiver operating characteristics showed that miRNAs 221, 17, and 23 were response-related in locally advanced rectal cancer patients. CONCLUSIONS: It seems that monitoring the miRNA/mRNA interactions during radiotherapy can be an appropriate diagnostic tool to track the recovery process and respond to standard therapies.
Assessment of a panel of miRNAs in serum and pleural fluid for the differential diagnosis of malignant and benign pleural effusion
Authors: Zhu Li-Rong , Yuan Rong-Xia , Xia Xian-Bin , Wang Yi , Zhu Yu-Min , Fi Ling , Li Jian
Published: August 2021

BACKGROUND: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge. OBJECTIVE: The aim of the study is to assess the efficacy of the serum and pleural fluid (PF) miRNA panels in distinguishing MPE from BPE. METHODS: Fourteen candidate miRNAs which were shown aberrant expression in lung cancer based on previous studies were tested by quantitative real-time PCR (qRT-PCR) in 20 MPE patients and 20 BPE patients. Significantly aberrantly expressed miRNAs were further assessed by qRT-PCR in all patients enrolled in this study. A receiver operating characteristic (ROC) curve was constructed, and the area under the ROC curve (AUC) was calculated to evaluated the diagnostic performance of the miRNAs. RESULTS: miR-21, miR-29c and miR-182 were found to be significantly aberrantly expressed in the serum and PF of MPE patients. The AUCs for the combination of miR-21, miR-29c and miR-182 in serum and PF were 0.832 and 0.89 respectively in distinguishing MPE from infection-associated PE including tuberculous pleurisy and parapneumonia PE, and 0.866 and 0.919 respectively for differentiating MPE from heart failure-associated PE, which were superior to AUC of each individual miRNAs. CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE.
E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity
Authors: Lu Yongbin , Su Fei , Yang Hui , Xiao Yi , Zhang Xiaobin , Su Hongxin , Zhang Tao , Bai Yana , Ling Xiaoling
Published: August 2021

BACKGROUND: Triple-negative breast cancer (TNBC) is a highly malignant breast cancer subtype with a poor prognosis. The cell cycle regulator cyclin A2 (CCNA2) plays a role in tumor development. Herein, we explored the role of CCNA2 in TNBC. METHODS: We analyzed CCNA2 expression in 15 pairs of TNBC and adjacent tissues and assessed the relationship between CCNA2 expression using the tissue microarray cohort. Furthermore, we used two TNBC cohort datasets to analyze the correlation between CCNA2 and E2F transcription factor 1 (E2F1) and a luciferase reporter to explore their association. Through rescue experiments, we analyzed the effects of E2F1 knockdown on CCNA2 expression and cellular behavior. RESULTS: We found that CCNA2 expression in TNBC was significantly higher than that in adjacent tissues with similar observations in MDA-MB-231 and MDA-MB-468 cells. E2F1 was highly correlated with CCNA2 as observed through bioinformatics analysis (R= 0.80, P< 0.001) and through TNBC tissue verification analysis (R= 0.53, P< 0.001). We determined that E2F1 binds the +677 position within the CCNA2 promoter. Moreover, CCNA2 overexpression increased cell proliferation, invasion, and migration owing to E2F1 upregulation in TNBC. CONCLUSION: Our data indicate that E2F1 promotes TNBC proliferation and invasion by upregulating CCNA2 expression. E2F1 and CCNA2 are potential candidates that may be targeted for effective TNBC treatment.
Plasma checkpoint protein 1 (Chk1) as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma
Authors: Phanaksri Teva , Yingchutrakul Yodying , Roytrakul Sittiruk , Prasopdee Sattrachai , Kunjantarachot Anthicha , Butthongkomvong Kritiya , Tesana Smarn , Sathavornmanee Thanakrit , Thitapakorn Veerachai
Published: August 2021

BACKGROUND: Patients infected with a parasite often develop opisthorchiasis viverrini, which often progresses into cholangiocarcinoma (CCA) due to the asymptomatic nature of the infection. Currently, there are no effective diagnostic methods for opisthorchiasis or cholangiocarcinoma. OBJECTIVE: The aim of this study was to identify the host-responsive protein that can be developed as a diagnostic biomarker of opisthorchiasis and cholangiocarcinoma. METHODS: Plasma samples were collected from non-OVCCA, OV, and CCA subjects, and the proteomes were investigated by LC-MS/MS. Venn diagrams and protein network prediction by STITCH were used to identify the potential biomarkers. The level of candidate protein, the plasma checkpoint protein 1 (Chk1), was measured by indirect enzyme-linked immunosorbent assay (ELISA). RESULTS: Chk1 was present in the center of the protein network analysis in both the OV and CCA groups. In addition, the plasma Chk1 levels were significantly increased in both groups (P< 0.05). The sensitivity of the opisthorchiasis viverrini and cholangiocarcinoma was 59.38% and 65.62%, respectively, while the specificity of both was 85.71%. CONCLUSION: Chk1 was identified by differential plasma proteomes and was increased in O. viverrini-infected and cholangiocarcinoma-derived plasma samples. Higher levels of plasma Chk1 levels may serve as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma.
Defeating antibiotic-resistant bacteria with protein-resistant polyGGE film
Authors: Zhou Shuo , Di Luca Mariagrazia , Xu Xun , Ma Nan , Jung Friedrich , Lendlein Andreas
Published: August 2021

Biofouling on medical device surfaces, which is initiated by protein adsorption and adhesion of microbes especially the antibiotic-resistant bacteria, attracts global attention for centuries due to its enduring challenges in healthcare. Here, the antifouling effect of hydrophilic poly(glycerol glycidyl ether) (polyGGE) film is explored in comparison to hemocompatible and protein-resistant control polymers. The chemical and thermomechanical stability of polyGGE in hydrated conditions at body temperature was achieved via adjusting UV curing and KOH quenching time. The polyGGE surface is inert to the plasma protein adsorption and interfered the metabolism conditions, biofilm formation and growth of both Gram negative (Gram–) and antibiotic-resistant Gram positive (Gram+) bacteria. These results indicate the potential application of polyGGE for combating the risk of hospital-acquired infections and preventing drug-resistant superbug spreading.
Exploring the relationship between corporate social responsibility actions and employee retention: A human resource management perspective
Authors: Boutmaghzoute Hajar , Moustaghfir Karim
Published: August 2021

BACKGROUND: This study builds on the little guidance in the existing literature to analyze the relationship between employee-oriented CSR actions and employee retention in a business context, while using Freeman’s stakeholders model as a theoretical research framework. This research also aims to shed light on significant behavioral factors facilitating the relationship between CSR endeavors and turnover rate. OBJECTIVE: This paper builds on the existing research gap in the literature and suggests that behavioral factors, including job satisfaction, organizational identification, and motivation facilitate the relationship between employee-oriented CSR actions and employee retention, which contributes to laying the foundations of a theoretical framework that has the potential to advance both research and practitioner debates and disentangle the complexity of such a relationship, while offering strategically-focused development venues in the CSR and HRM fields. METHODS: This research uses a single case study design to ensure an in-depth and detailed analysis of the phenomenon under scrutiny, while relying on a triangulation methodology for data collection, including a questionnaire used as exploratory approach, interviews to generate explanatory data, and archival data to bring confirmatory insights. Data analysis followed the procedures of a deductive approach. RESULTS: The research results show a positive relationship between employee-oriented CSR actions and employee retention, while demonstrating the facilitating role of job satisfaction, organizational identification, and motivation in moderating such a relationship. The findings also stress the importance of framing CSR interventions within the organization’s strategy and goals, while ensuring employee participation in such decision making processes to maximize the effect of CSR interventions on employee commitment and reduce turnover. CONCLUSIONS: This research has the potential to better clarify the nature of the relationship involving CSR interventions, from an employee perspective, retention, and turnover, while laying the foundations of a theoretical framework linking such constructs and other behavioral factors that underpin and support such a relationship. Building on the study’s findings and assumptions, future research is needed to gain a more comprehensive understanding of how HR-related CSR actions affect behavioral performance dimensions, resulting in employee commitment and retention. Future research should also consider multiple case study, multicultural, and ethnographic approaches for the sake of generalizability and theory building.
Neuropsychological Predictors of Severe Functional Dependency in a Multiethnic Community Cohort of Individuals with Alzheimer’s Disease
Authors: Cárcamo Jasmine , Kociolek Anton J. , Fernández Kayri K. , Gu Yian , Zhu Carolyn W. , Stern Yaakov , Cosentino Stephanie
Published: August 2021

To assess the predictive value of neuropsychological tests for severe dependency in Alzheimer’s disease as defined by the Equivalent Institutional Care Rating Scale, in a multiethnic, community cohort. The sample included 146 elders from the Predictors 3 cohort. Cox proportional hazard models tested the predictive value of each neuropsychological test at baseline on relative risk of meeting severe dependency. Higher semantic processing and memory test scores at baseline were associated with lower risk of meeting severe dependency in the adjusted Cox models. The integrity of semantic processing and memory abilities in dementia appears to predict time to severe functional dependency.
Mathematical formulation of the film thickness in a multi-pad externally adjustable hydrodynamic bearing using the transformation technique
Authors: Ganesha A. , Raghuvir Pai , Abdul Khader S.M.
Published: August 2021

Instability problem of a hydrodynamic plain journal bearing at higher speeds is conventionally resolved by using the non-circular bearings. High speed precision rotating shafts demands accurate positioning of the journal centres. A multi-pad adjustable bearing is a non-circular bearing, provides a fine-tuning option of the journal centre by continuously changing the bearing profile. In the present study, the bearing has a configuration of four bearing pads that are adjustable both in the radial and tilt directions. The fluid film thickness profile is conventionally obtained using the trigonometric relations, which has computational limitations, especially in multi-pad adjustable bearings. In this investigation, the film thickness profile of a multi-pad adjustable bearing is mathematically formulated using the transformation technique. The results obtained are compared with those available in the literature for a similar bearing. The observation shows that transformation technique eliminates the projection approximation error present in the conventional technique.
Effect of alkali treatment on physical and mechanical properties of bamboo short fibers
Authors: Nayak Suhas Yeshwant , Shenoy K. Rajath , Samant Rashmi , Sarvade Praneeth P. , Shenoy B Satish , Bin Hameed Sultan Mohamed Thariq , Kini Chandrakant R.
Published: August 2021

Bamboo (Arundinaria clarkei) short fibers were treated with 6% conc. NaoH solution for five different durations viz. 3 h, 6 h, 9 h, 12 h and 24 h. Effect on physical properties like diameter and density were studied. Fibers were examined using Scanning Electron Microscope (SEM) to study the effect of alkali treatment on its surface characteristics. Single fiber tensile tests were conducted to assess the tensile strength of the fibers. Comparative study of the SEM micrographs indicated removal of outer layer with the surface irregularities becoming more prominent with increasing duration. The fiber surface was scanned using an Atomic Force Microscope (AFM) to quantify the increase in surface roughness with alkali treatment. Tests results showed positive effect on the strength till 6 h beyond which the tensile strength was observed to reduce. Fourier Transform Infrared (FTIR) spectroscopy results indicated reduction in content of holocellulose along with hemicellulose, lignin and cellulose which explains the variation in tensile strength with increasing duration of treatment.
Hybrid solar-wind 250 w supply Ac/Dc for centralized charging station in HEI
Authors: Ytis Mario Alexis R. , Janipin Ian James Z. , Oplas Jonathan L. , Leano Wilfredo N. , Epa Ericko June S. , Siguenza Rudy M.
Published: August 2021

The continuous use of fossil fuels are destined to run out and by definition are the nonrenewable resource. Economies forces change with the depletion of fossil fuels. Renewable energies are increasingly competitive energy, sources of clean, and inexhaustible. Differing from fossil fuels principally in the abundance, diversity, and potential for use on the planet, but produces neither greenhouse gases that cause climate change and polluting emissions. The objective of our research is to create a hybrid solar and wind renewable energy. Used as a source of electrical power to supply a charging station will be implemented in High Education institution. This will solve the problem of students using school electricity and adding convenience outlets that will use renewable energy and for the method, using a Mono-crystalline Solar panel and Vertical-Axis Wind Turbine to generate a total of 250 W being hybrid. The results of the research that we have conducted give us the maximum output of our hybrid solar and wind which is 250 W and the discharge time of the battery maximum of 5 hrs having a load of 250 W and the charge rate is 24 Ampere-hour. This Hybrid device will run and charge 24 hours due to an optimum combination, the impact of the variable nature of solar and wind resources is partially resolved, and the overall system becomes more reliable and economical to run. The role of this renewable energy-based hybrid power systems play in meeting the increased demand for clean electricity.
Deformation characteristics of functionally graded bio-composite plate using higher-order shear deformation kinematics
Authors: Jena S. , Karakoti A. , Kar V.R. , Jayakrishna K. , Sultan M.T.H.
Published: August 2021

Deformation behavior of functionally graded bio- composite plate structures subjected to uniform pressure are examined and presented. Here, biocompatible metals/alloys and ceramics are utilized as constituent materials throughout in the analysis. The material properties of functionally graded bio- composite plate are evaluated through power-law distribution based Voigt’s micromechanical scheme. The displacement field is defined in third-order shear deformation mid-plane kinematics. However, the motion equations are governed by minimizing total potential energy. The deflection responses are obtained in finite element framework using nine noded quadrilateral element. To confirm the correctness of the present finite element model, the present results are compared with the reported results. In addition, various numerical illustrations are demonstrated to exhibit the significance of different geometrical and material parameters on the deformation behaviour of functionally graded bio-composite plate structure, and discussed in detail.
Development of integrated supply chain system in manufacturing industry
Authors: Sulaiman S. , Aldeehani A. , Alhajji M. , Aziz F.A.
Published: August 2021

This paper presents the model of integrated halal supply chain in food manufacturing industries. There is global increase in the demand for halal products by Islamic countries as well as by non-Islamic countries. Halal food consumers are presently more alert and concern about the integrity of Halal status. Furthermore, they also curious about all the activities involved along the supply chain whether the products that they purchased were truly halal from the beginning to the end. The need of halal supply chain is crucial in ensuring that the concept of halal is not only applicable for the food itself but also for the whole supply chain starting from the farm to the customer. This project attempts to develop an integrated halal supply chain system that can be used by food manufacturers that are developing halal products for better productivity and quality. The identified supply chain components are human resources, process, environment, accreditations, logistics and traceability.
Resource clustering algorithm for cloud data centers
Authors: Song Caili , Liang Bin , Li Jiao
Published: August 2021

Recently, the virtual machine deployment algorithm uses physical machine less or consumes higher energy in data centers, resulting in declined service quality of cloud data centers or rising operational costs, which leads to a decrease in cloud service provider’s earnings finally. According to this situation, a resource clustering algorithm for cloud data centers is proposed. This algorithm systematically analyzes the cloud data center model and physical machine’s use ratio, establishes the dynamic resource clustering rules through k-means clustering algorithm, and deploys the virtual machines based on clustering results, so as to promote the use ratio of physical machine and bring down energy consumption in cloud data centers. The experimental results indicate that, regarding the compute-intensive virtual machines in cloud data centers, compared to contrast algorithm, the physical machine’s use ratio of this algorithm is improved by 12% on average, and its energy consumption in cloud data center is lowered by 15% on average. Regarding the general-purpose virtual machines in cloud data center, compared to contrast algorithm, the physical machine’s use ratio is improved by 14% on average, and its energy consumption in cloud data centers is lowered by 12% on average. Above results demonstrate that this method shows a good effect in the resource management of cloud data centers, which may provide reference to some extent.
Menger’s theorem for m-polar fuzzy graphs and application of m-polar fuzzy edges to road network
Authors: Akram Muhammad , Siddique Saba , Ahmad Uzma
Published: August 2021

The main objective of this research article is to classify different types of m-polar fuzzy edges in an m-polar fuzzy graph by using the strength of connectedness between pairs of vertices. The identification of types of m-polar fuzzy edges, including α-strong m-polar fuzzy edges, β-strong m-polar fuzzy edges and δ-weak m-polar fuzzy edges proved to be very useful to completely determine the basic structure of m-polar fuzzy graph. We analyze types of m-polar fuzzy edges in strongest m-polar fuzzy path and m-polar fuzzy cycle. Further, we define various terms, including m-polar fuzzy cut-vertex, m-polar fuzzy bridge, strength reducing set of vertices and strength reducing set of edges. We highlight the difference between edge disjoint m-polar fuzzy path and internally disjoint m-polar fuzzy path from one vertex to another vertex in an m-polar fuzzy graph. We define strong size of an m-polar fuzzy graph. We then present the most celebrated result due to Karl Menger for m-polar fuzzy graphs and illustrate the vertex version of Menger’s theorem to find out the strongest m-polar fuzzy paths between affected and non-affected cities of a country due to an earthquake. Moreover, we discuss an application of types of m-polar fuzzy edges to determine traffic-accidental zones in a road network. Finally, a comparative analysis of our research work with existing techniques is presented to prove its applicability and effectiveness.
A heuristics pulse algorithm with relaxation pruning strategy for resources re-initialized UAV path planing
Authors: Chen Xinghao , Zhou Bin
Published: August 2021

Path planning is the basis and prerequisite for unmanned aerial vehicle (UAV) to perform tasks, and it is important to achieve precise location in path planning. This paper focuses on solving the UAV path planning problem under the constraint of system positioning error. Some nodes can re-initiate the accumulated flight error to zero and this type of scenario can be modeled as the resource-constrained shortest path problem with re-initialization (RCSPP-R). The additional re-initiation conditions expand the set of viable paths for the original constrained shortest path problem and increasing the search cost. To solve the problem, an effective preprocessing method is proposed to reduce the network nodes. At the same time, a relaxed pruning strategy is introduced into the traditional Pulse algorithm to reduce the search space and avoid more redundant calculations on unfavorable scalable nodes by the proposed heuristic search strategy. To evaluate the accuracy and effectiveness of the proposed algorithm, some numerical experiments were carried out. The results indicate that the three strategies can reduce the search space by 99%, 97% and 80%, respectively, and in the case of a large network, the heuristic algorithm combining the three strategies can improve the efficiency by an average of 80% compared to some classical solution.
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
Authors: Guerra-Rebollo Marta , Stampa María , Lázaro Miguel Ángel , Cascante Anna , Fornaguera Cristina , Borrós Salvador
Published: August 2021

Background: Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. Novel approximations are trying to treat these patients with gene therapy, namely, using viral vectors. However, these vectors can be recognized by the immune system decreasing their therapeutic activity and making impossible a multidose treatment due to the induction of the humoral immunity following the first dose. Objective: Our objective is to demonstrate the feasibility of using a hybrid vector to avoid immune clearance, based on the electrostatic coating of adeno-associated virus (AAVs) vectors with our proprietary polymers. Methods: We coated model adeno-associated virus vectors by electrostatic interaction of our cationic poly (beta aminoester) polymers with the viral anionic capsid and characterized biophysical properties. Once the nanoformulations were designed, we studied their in vivo biodistribution by bioluminescence analysis and we finally studied the capacity of the polymers as potential coatings to avoid antibody neutralization. Results: We tested two polymer combinations and we demonstrated the need for poly(ethylene glycol) addition to avoid vector aggregation after coating. In vivo biodistribution studies demonstrated that viral particles are located in the liver (short times) and also in muscles (long times), the target organ. However, we did not achieve complete antibody neutralization shielding using this electrostatic coating. Conclusions: The null hypothesis stands: although it is feasible to coat viral particles by electrostatic interaction with a proprietary polymer, this strategy is not appropriate for AAVs due to their small size, so other alternatives are required as a novel treatment for DMD patients.
Next-Generation Gene Therapy for Parkinson’s Disease Using Engineered Viral Vectors
Authors: Björklund Tomas , Davidsson Marcus
Published: August 2021

Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their potential in treating Parkinson’s disease (PD). Clinical trials in PD have shown over the last decade that AAV is a safe and suitable vector for gene therapy but that it also is a vehicle that can benefit significantly from improvement in specificity and potency. This review provides a concise collection of the state-of-the-art for synthetic capsids and their utility in PD. We also summarize what therapeutical strategies may become feasible with novel engineered vectors, including genome editing and neuronal rejuvenation.
Azidation of aryl halides promoted by EDTA
Authors: Rezapour Mehdi , Ghorbani Sirous , Khodabakhshi Mohammad Reza , Abbasi Mohammad
Published: August 2021

An efficient approach to azidation of aryl halides is described here. Good yields of aryl azides were obtained with [CuI/EDTA]–3 as a catalytic system. Cost-affectivity of the EDTA compared to expensive DMEDA (1 : 500 times) along with the use of 7EtOH:3H2O as mixed solvent and green medium makes it to be a suitable method for selective synthesis of aryl azides.
The interaction between carboplatin anticancer drug and B12N12 nano-cluster: A computational investigation
Authors: Shabani Mozhdeh , Ghiasi Reza , Zare Karim , Fazaeli Reza
Published: August 2021

This study investigated the interaction between B12N12 nano-cluster and carboplatin complex using B3P86 functional. Two interaction modes between B12N12 nano-cluster and carboplatin complex were considered. The bonding interaction between the B12N12 nano-cluster and carboplatin complex was examined through energy decomposition analysis (EDA). Also, Shubin Liu’s energy decomposition analysis (EDA-SBL) is used to study the source of energy differences between various isomers of B12N12 ...  carboplatin complex. Charge transfer between fragments were illustrated with electrophilicity-based charge transfer (ECT) and extended charge decomposition analysis (ECDA). The quantum theory of atoms in molecules (QTAIM) analysis was applied to assess the Pt-B and Pt-N bonds within B12N12 ...  carboplatin complex.
Chitosan (Poly-(D) glucosamine) based solid lipid nanoparticles of dexibuprofen for topical delivery: Formulation development and characterizations
Authors: Ullah Irshad , Shah Shefaat Ullah , Khan Muhammad Khalid , Shah Kifayat Ullah , Khan Barkat Ali
Published: August 2021

Chitosan a poly-(D) glucosamine is a polysaccharide made by treating shrimp and other crustacean shells with the alkali sodium hydroxide. It is a hydrophilic polymer that helps to retain the drug inside the solid lipid nanoparticles (SLN’s) and prolongs the release of drug from the carrier system. The purpose of the study was to formulate Chitosan decorated SLN’s for the topical delivery of dexibuprofen by hot pressure homogenization technique. Blank SLN’s, drug loaded SLN’s and Chitosan decorated SLN’s were prepared. Particle size, zeta potential and PDI were determined. FTIR study was conducted to evaluate the compatibility of excipients with the active drug. Surface morphology of SLN’s was determined by field emission scanning electron microscope. Drug content and entrapment efficiency of SLN’s were determined using indirect method. In vitro release and ex vivo permeation study of SLN’s were carried out using Franz diffusion cell. The droplet size fell into the nano range i.e. 132±7 to 424±2 nm which is effective for topical drug delivery system. The PDI of formulations range from 0.21 to 0.42 which depicts the homogeneity of all the SLN’s formulations. Vibrational analysis indicates that there is no interaction between active drug and excipient used in the formulation. The surface morphology revealed the spherical shape of Chitosan decorated SLN’s. The in vitro release of formulations showed 79.91±1.07 to 89.94±1.8 % drug release. The drug permeation study showed high permeation of drug into the skin. The percent drug permeation ranges from 64.15±0.93 to 71.80±0.88% indicating good permeation of drug across the skin. Overall, SLN’s are an effective carrier for topical delivery of dexibuprofen and thus bypasses side effects associated with oral delivery.