bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Constituents and Cytotoxicity of Euphorbia vajravelui
Authors: Anju Vijayalekshmi , Priya Sulochana , Baby Sabulal , Rameshkumar Koranappallil Bahuleyan
Published: November 2018

Euphorbia species are important in traditional medicines as well as in horticulture. Though
82 Euphorbia species are reported from India, most of the species are yet to be explored for the
phytochemicals or bioactivities. The present study reports the phytochemical and cytotoxicity studies
of the Western Ghats endemic plant Euphorbia vajravelui. Compounds were isolated from the extracts
of E. vajravelui using column chromatography and were characterized through various spectroscopic
techniques. The structures were further confirmed through single crystal XRD. The major pentacyclic
triterpene 3β-friedelinol was estimated using a validated HPTLC method. Cytotoxicity of the extracts
was tested against human cervical cancer cell line HeLa and normal cardiac myoblasts cell line H9C2
using MTT assay. The pentacyclic triterpenoids taraxeryl acetate, epi-friedelinyl acetate, 3β-friedelinol,
taraxerol, 3α-friedelinol and friedelane-2β,3α-diyl diacetate and the phenolic compound 3,4,3'-tri-Omethyl
ellagic acid 4'-rutinoside were isolated and characterized from E. vajravelui. Single crystal
XRD data of epi-friedelinyl acetate, taraxerol and 3α-friedelinol were also reported. The major compound
3β-friedelinol was found to contain 0.33 ± 0.03%, estimated through a validated HPTLC
method. The extracts were non-toxic towards normal cell line H9C2 (cardiac myoblasts) and showed
negligible cytotoxic effects towards cervical cancer cell line HeLa upto100 µg/mL concentration. The
major compounds isolated from E. vajravelui were triterpenoids and single crystal XRD data unambiguously
confirmed the structures. The latex extract was non toxic towards normal cell line H9C2 and
cancer cell line HeLa and the result was relevant especially in the context of the eco-toxicological concerns
around Euphorbia species. This is the first report of the phytochemical and cytotoxicity studies
of the Western Ghats endemic species E. vajravelui.
Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters
Authors: Fotopoulos Ioannis , Pontiki Eleni , Litina Dimitra Hadjipavlou
Published: November 2018

Background:

Cinnamic acid is a key intermediate in shikimate and phenylpropanoid pathways. It is found both in free form, and especially in the form of esters in various essential oils, resins and balsams which are very important intermediates in the biosynthetic pathway of several natural products. The cinnamic derivatives play a vital role in the formation of commercially important intermediate molecules which are necessary for the production of different bioactive compounds and drugs. Different substitutions on basic moiety lead to various biological activities. Furthermore, combination of appropriate pharmacophore groups with cinnamic acid derivatives were developed to give hybrids in order to find out promising drug candidates as inhibitors of multiple biological targets associated with inflammation. We found interesting to continue our efforts to design and synthesise three series of novel cinnamic acid-based hybrids: a) nitrooxy esters of cinnamic acid, b) ethers and c) amides of cinnamic acids with arginine, as pleiotropic candidates against multiple targets of inflammation.

Methods:

The synthesis of cinnamic was established by a Knoevenagel-Doebner condensation of the suitable aldehyde either with malonic acid in the presence of pyridine and piperidine, or with phenylacetic acid in the precence of triethylamine in acetic anhydride. The synthesis of the corresponding esters was conducted in two steps. The ethers were synthesized in low yields, with 1,2 – dibromoethane in dry acetone, in the presence of K2CO3, to give oily products. The corresponding cinnamic amides were synthesised in a single step. The synthesised hybrids were tested as lipoxygenase (LOX) and cyclooxygenase (COX) inhibitors in vitro. In silico docking was applied to all the novel derivatives. Several molecular properties of the hybrids were calculated in order to evaluate their drug likeness.

Results:

A number of esters, ethers and amides of selected cinnamic acids, either phenyl substituted or not, has been synthesised and subjected to modelling studies. The compounds were studied in vitro/in vivo for their inhibitory activities on cox and lox, and as antioxidants. Log P values of all the title compounds except of 3a (5.38) were found to be less than 5 and are in agreement to Lipinski’s rule of five, suggesting satisfactory permeability across cell membrane. The molecular modelling study seems to be in accordance with the experimental results for LOX and COX-2. The result of antioxidant activity for amide 3b supports the anti-lox activity. Compound 5d presents the higher in vivo anti-inflammatory.

Conclusion:

According to the experimental findings compounds 3b and 5d can be used as lead compounds for the design of new molecules to target inflammation.
Dietary and Lifestyle Factors and Breast Cancer Risk
Authors: Mahmoud Reema I. , Tayyem Reema F.
Published: November 2018

Breast cancer (BC) is the most frequently diagnosed type of cancer and the leading cause
of cancer deaths in women worldwide. A number of established risk factors for BC have been identified
in many previous studies which included age, reproductive history, lactation, hormone levels or
use, genetic factors, breast density and various diet and lifestyle factors. Several previous studies
highlighted the independent effect of dietary patterns, lifestyle factors, macro- and micronutrients intake,
physical activity, tobacco smoking, and weight gain on the risk BC. Although a number of risk
factors have been identified for BC, however, some are difficult to modify such as genetic factors,
while dietary pattern, physical activity, nutrient intake and smoking are modifiable risk factors which
could be targeted to reduce the risk of this devastating disease. Even though there is a quick advancement
in BC cancer therapy, but still, the survival rate is not increasing. Therefore, preventing
cancer development is more important than treating or inhibiting its progression and such prevention
can reduce the suffering and pain of patients and their families.
Design, Synthesis, Anticonvulsant Activity, Preclinical Study and Pharmacokinetic Performance of N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin- 2-yl] methyl}, 2-[(2-isopropyl-5-methyl) 1-cyclo Hexylidene] Hydrazinecarboxamide
Authors: Yadav Meena K. , Tripathi Laxmi
Published: November 2018

Background:

N-{[3-(4-chlorophenyl)-4-oxo-3, 4-dihydroquinazolin-2-yl] methyl}, 2-[(2- isopropyl-5-methyl) 1-cyclohexylidene] hydrazinecarboxamide QS11 was designed by computational study. It possessed essential pharmacophoric features for anticonvulsant activity and showed good docking with iGluRs (Kainate) glutamate receptor.

Methods:

QSAR and ADMET screening results suggested that QS11 would possess good potency for anticonvulsant activity. QS11 was synthesised and evaluated for its anticonvulsant activity and neurotoxicity. QS11 showed protection in strychnine, thiosemicarbazide, 4-aminopyridine and scPTZ induced seizure models and MES seizure model. QS11 showed higher ED50, TD50 and PI values as compared to the standard drugs in both MES and scPTZ screen. A high safety profile (HD50/ED50 values) was noted and hypnosis, analgesia, and anaesthesia were only observed at higher doses. No considerable increase or decrease in the concentration of liver enzymes was observed. Optimized QS11 was subjected to preclinical (in-vivo) studies and the pharmacokinetic performance of the sample was investigated. The result revealed that the pharmacokinetic performance of QS11 achieved maximum plasma concentrations (Cmax) of 0.315 ± 0.011 µg/mL at Tmax of 2.0 ± 0.13 h, area under the curve (AUC0-∞) value 4.591 ± 0.163 µg/ml x h, elimination half-life (T1/2) 6.28 ± 0.71 h and elimination rate constant was found 0.110 ± 0.013 h-1.

Results and Conclusion:

Above evidences indicate that QS11 could serve as a lead for development of new antiepileptic drugs.
Efficient Bag-of-Features using Improved Whale Optimization Algorithm for Histopathological Image Classification
Authors: Tiwari Varun , Jain Sushil C.
Published: November 2018

Background:

The whale optimization algorithm is one of the popular meta-heuristic algorithms which has successfully been applied in various application areas such as image analysis and data clustering. However, the slow convergence rate and chances of sticking into the local optima due to improper balance of its exploration and exploitation phases are some of its pitfalls. Therefore, in this paper, a new improved whale optimization algorithm has been proposed. Moreover, the proposed method has been used in bag-of-features method for histopathological image classification.

Methods:

The new algorithm, improved whale optimization algorithm, modifies the encircling phase of original whale optimization algorithm. The proposed algorithm has been used to cluster the extracted features for finding the relevant codewords to be used in the bag-of-features method for histopathological image classification.

Results:

The efficiency of proposed algorithm has been analyzed on 23 benchmark functions in terms of mean fitness, standard deviation values, and convergence behavior. The performance of the improved whale optimization algorithm based histopathological image classification method has been analyzed on blue histology image dataset and compared with other meta-heuristic based bagof- features methods in terms of recall, precision, F-measure, and accuracy. The experimental results validate that the proposed method outperforms the considered state-of-the-art methods and attains 12% increase in the histopathological image classification accuracy.

Conclusion:

In this paper, a new improved whale optimization algorithm has been proposed and applied in bag-of-features method for histopathological image classification. The results of proposed method outperform the other existing meta-heuristic methods over standard benchmark functions and histopathological image dataset.
SVM and HMM Classifier Combination Based Approach for Online Handwritten Indic Character Recognition
Authors: Ghosh Rajib , Kumar Prabhat
Published: November 2018

Background:

The growing use of smart hand-held devices in the daily lives of the people
urges for the requirement of online handwritten text recognition. Online handwritten text recognition
refers to the identification of the handwritten text at the very moment it is written on a digitizing
tablet using some pen-like stylus. Several techniques are available for online handwritten text
recognition in English, Arabic, Latin, Chinese, Japanese, and Korean scripts. However, limited research
is available for Indic scripts.

Objective:

This article presents a novel approach for online handwritten numeral and character (simple
and compound) recognition of three popular Indic scripts - Devanagari, Bengali and Tamil.

Methods:

The proposed work employs the Zone wise Slopes of Dominant Points (ZSDP) method for
feature extraction from the individual characters. Support Vector Machine (SVM) and Hidden Markov
Model (HMM) classifiers are used for recognition process. Recognition efficiency is improved
by combining the probabilistic outcomes of the SVM and HMM classifiers using Dempster-Shafer
theory. The system is trained using separate as well as combined dataset of numerals, simple and
compound characters.

Results:

The performance of the present system is evaluated using large self-generated datasets as
well as public datasets. Results obtained from the present work demonstrate that the proposed system
outperforms the existing works in this regard.

Conclusion:

This work will be helpful to carry out researches on online recognition of handwritten
character in other Indic scripts as well as recognition of isolated words in various Indic scripts including
the scripts used in the present work.
Removal of Cr(VI) from Aqueous Solutions Using Amino‐Functionalized Carbon Nanospheres Adsorbents
Authors: Benadji Naoual , Ikkene Rafika , Boudjemaa Amel , Bendjama Zoubida , Bachari Khaldoun , Hamoudi Safia
Published: November 2018

Carbon nanospheres were prepared and functionalized with carboxyl acid groups (CNS‐CA), then reacted with 3‐aminopropyltriethoxysilane to introduce amino groups onto the surface (CNS‐NH2) by post‐synthesis grafting. CNS‐NH2 was acidified in order to convert the amino groups (‐NH2) into ammonium moieties (). Various techniques such as N2 physisorption, X‐ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetry, X‐ray photoelectron spectroscopy, and transmission electron microscopy were used to characterize the nanospheres. The removal of chromium ions from aqueous solution using was investigated. Factors influencing the uptake of Cr(VI) ions such as solution pH, adsorbent dose, and initial Cr(VI) ion concentration were investigated. Equilibrium adsorption data fitted the Langmuir model very well. The adsorption maximum capacity of Cr(VI) was found to be 52.38 mg/g. The reusability of results indicated that it can be reused five times successfully without loss of adsorption capacity.
Reconstrucción paleoambiental de la subcuenca de Xochimilco, centro de México, entre 18000 y 5000 años antes del presente
Authors: Ortega-Guerrero Beatriz , Albarrán-Santos Marco Albán , Caballero Margarita , Reyes-Corona Ismerai , Gutiérrez-Méndez Brayan , Caballero-García Lizeth
Published: November 2018

Presentamos un registro de las oscilaciones de escala milenaria de un sitio en la cuenca de Xochimilco (parte central de México) entre ca. 18000 y 5000 años cal AP, derivado de indicadores de mineralogía magnética, contenido de elementos mayores y asociación de diatomeas. La edad de la secuencia sedimentaria analizada está definida por el reconocimiento de dos marcadores estratigráficos ampliamente usados en esta región: la Pómez Tutti Frutti del Popocatépetl (ca. 17070 años cal AP) y la Pómez Toluca Superior del Nevado de Toluca (ca. 12320 años cal AP). Adicionalmente, se dispone de una edad de 14C de un concentrado de ostrácodos. Las variaciones temporales en susceptibilidad magnética (χ), abundancia de óxidos y oxihidróxidos de Fe (hematita y goethita), minerales magnéticos ultrafinos, titanio, carbón orgánico e inorgánico, así como las relaciones hierro/titanio, calcio/titanio, carbono orgánico/nitrógeno, silicio/titanio y contenido de diatomeas, indican variaciones en la erosión, origen de los minerales de Fe, salinidad, productividad y origen de la materia orgánica. Estas variaciones responden a oscilaciones climáticas de escalas milenarias. Durante la deglaciación (18000 y 11700 años cal AP), ocurrió una actividad volcánica intensa y este periodo está caracterizado por la dominancia de sedimentación clástica en un lago somero de agua dulce. Los eventos Heinich 1 (frío), Bølling/Allerød (cálido) y Younger Dryas (frío) se documentan con variaciones en la erosión, el contenido de materia orgánica y la precipitación de carbonatos. Durante el Holoceno temprano (11700–8200 años cal AP), se registraron las condiciones más secas de toda la secuencia. El Holoceno medio (8200–5000 años cal AP) registró un retorno a condiciones húmedas y el establecimiento de un lago de agua dulce, que probablemente favorecieron el desarrollo de comunidades en la ribera del lago.
El camino menos transitado: Escritura expresiva autobiográfica con migrantes Norte-Sur a Guanajuato, México
Authors: Chibici-Revneanu Claudia Christina
Published: November 2018

This article parts from the assumption that some common notions about migration are “narrative” in nature - both half-fictions and socially constructed “realities”. It looks at a trend frequently neglected by hegemonic narratives of human movement, namely North-South migration. More specifically, it focuses on some migrants to the state of Guanajuato, Mexico and their writings produced during two intercultural expressive and autobiographical writing workshops. The study draws from an interdisciplinary methodology, including migration studies with a sociological, anthropological, economic and psychological outlook, expressive writing studies, and narrative analysis of texts created. The workshop writings revealed both an emergent sense of a “common humanity” among participant movers, and the significant complexity of individual migrant experiences. Many of the tales told indeed questioned common “migration narratives” like neat nation-state to nation-state movement and North-South divisions, thus opening spaces for re-imagining migration in its full human universality, diversity and complexity.
Gaya hidup hedonis dan intensi korupsi pada mahasiswa pengurus lembaga intra kampus
Authors: Sartika Yuniar Dwi , Hudaniah Hudaniah
Published: November 2018

Abstrak. Kasus korupsi banyak terjadi di lembaga pemerintahan sehingga intensi korupsi berpotensi terjadi di lembaga intra kampus yang merupakan miniatur dari lembaga pemerintahan. Intensi korupsi merupakan niat untuk melakukan korupsi. Banyak dijumpai individu memiliki gaya hidup hedonis, termasuk mahasiswa. Gaya hidup hedonis merupakan pola hidup yang mengutamakan kesenangan semata. Ketika individu tidak memiliki cukup uang untuk menunjang gaya hidup hedonisnya maka ia akan memiliki intensi korupsi. Tujuan penelitian ini untuk mengetahui adakah hubungan gaya hidup hedonis dan intensi korupsi. Penelitian ini merupakan penelitian kuantitatif korelasional dengan menggunakan teknik purposive sampling yang melibatkan 135 mahasiswa pengurus lembaga intra berusia 18-22 tahun. Pengambilan data menggunakan skala gaya hidup hedonis dan skala intensi korupsi yang dibuat sendiri oleh peneliti. Data yang didapatkan dianalisis menggunakan analisis product moment. Hasil penelitian menunjukkan adanya hubungan positif yang signifikan antara gaya hidup hedonis dengan intensi korupsi pada mahasiswa pengurus lembaga intra. Semakin tinggi gaya hidup hedonis mahasiswa, akan semakin tinggi pula intensi korupsinya.Kata Kunci: Gaya hidup hedonis, intensi korupsi, mahasiswa pengurus lembaga intraAbstract. Many corruption cases occurred in government institutions so that intention of corruption have the potential to occur in intra-campus institutions that are miniatures of government institutions. The intention of corruption is the intention to commit corruption. Many individuals are found to have hedonic lifestyles, including students. Hedonic lifestyle is a lifestyle that prioritizes pleasure. When an individual does not have enough money to support his hedonic lifestyle he will have a intention of corruption. The purpose of this research is to know whether there is any relationship of hedonic lifestyle and intention of corruption. This research is a correlational quantitative research using puposive sampling technique involving 135 students of intra institution aged 18-22 years. Data is retrieved using hedonic lifestyle scale and intention of corruption scale by researchers. The data obtained were analyzed using product moment analysis. The results showed a significant positive correlation between hedonic lifestyles with intention of corruption on students of intra institution. The highly of hedonic lifestyle of students, could be highly of their intention of corruption.Keywords:  Hedonic lifestyle, intention of corruption, student of intra institution
Identifying the dimensions of logistics service quality in an online B2C context
Authors: Gligor David M
Published: November 2018

There is theoretical and practical evidence indicating the existence of significant differences between the needs and wants of firms and end consumers, as well as the existence of significantly different needs between offline and online environments. Therefore, it is not clear how effectively measures of logistics service quality developed in an offline, B2B context can be applied to an online, B2C environment. This manuscript explores the elements of logistics service quality that end consumers value in an online context. The literature on logistics service quality in B2B and the literature on online consumer satisfaction are integrated. This results in the development of a set of dimensions for measuring online logistics service quality in online, B2C environments. Specifically, the dimensions of a new scale for measuring online logistics service quality (labeled oLSQ) were identified and defined. Managers can use the dimensions of logistics service quality identified in the oLSQ scale as a guide when designing and managing online retail stores.
Pengembalian Mahar Berganda Karena Pembatalan Khitbah dalam Pandangan Islam: Analisis terhadap Persepsi dan Praktek Masyarakat Kuta Baro Aceh Besar
Authors: Saifuddin Saâ€™dan Saifuddin Saâ€™dan , Arif Afandi Arif Afandi
Published: November 2018

Ketika terjadi pembatalan khitbah oleh calon mempelai perempuan fuqaha sepakat bahwa calon mempelai perempuan harus mengembalikan pemberian tersebut. Berbeda halnya pada masyarakat Kuta Baro Aceh Besar ketika terjadi pembatalan khitbah oleh calon mempelai perempuan maka pemberian yang pernah diberikan oleh calon mempelai laki-laki yang tujuannya untuk mahar maka calon mempelai perempuan harus mengembalikannya secara berganda. Adapun rumusan masalah dalam skripsi ini adalah bagaimana praktek pengembalian mahar karena pembatalan khitbah pada masyarakat Kuta Baro Aceh Besar dan bagaimana pandangan Islam terhadap praktek pengembalian mahar karena pembatalan khitbah pada masyarakat Kuta Baro Aceh Besar. Dalam penelitian penulis menggunakan metodedeskriptif analisis, yaitu metode dengan menggambarkan objek dan dianalisa dari data-data yang diperoleh di lapangan. Hasil penelitian menunjukkan bahwa praktek pengembalian mahar karena pembatalan khitbah pada masyarakat Kuta Baro Aceh Besar dilakukan dengan mengembalikanpemberian yang tujuannya untuk mahardua kali lipat (ganda) yang pernah diberikan oleh calon mempelai laki-laki ketika mengkhitbahnya. Dikembalikannya pemberian tersebut dua kali lipat atau ganda apabila pembatalan khitbahitu dilakukan oleh pihak calon mempelai perempuan dan pandangan hukum Islam terhadap pembatalan khitbah oleh calon mempelai perempuan dengan membayar pemberian dua kali lipat yang biasa berlaku di masyarakat Kuta Baro Aceh Besar merupakan hukuman taâ€™zir yang berupa harta (denda) dua kali lipat pemberian, karena bentuk dari ingkar janji atau melanggarnya dari pihak perempuan terhadap perjanjian untuk melaksanakan pernikahan.
Pandangan Imam Ibnu Taimiyah tentang Perkawinan Laki-Laki Muslim dengan Wanita Ahlul Kitab
Authors: Abubakar Al Yasa , Novita Novita
Published: November 2018

Secara normatif, Islam telah melegalkan laki-laki muslim menikahi wanita ahlul kitab berdasarkan ketentuan surat al-Maidah ayat 5. Namun, dalam ranah fikih, justru masih ditemukan perbedaan pendapat ulama. Menariknya, perbedaan pendapat tersebut tidak hanya terjadi pada tataran hukum pernikahannya, tetapi juga perbedaan dalam memaknai arti dari ahlul kitab itu sendiri, yang pada gilirannya juga berbeda dalam penetapan hukum pernikahannya. Secara khusus, artikel ini mengkaji pandangan Imam Ibnu Taimiyah tentang perkawinan laki-laki muslim dengan wanita ahlul kitab, dengan tujuan untuk mengetahui dalil dan metode istinbath hukum yang digunakan Imam Ibnu Taimiyah, serta mengetahui ada tidaknya kesesuaian pendapat Ibnu Taimiyah dengan hukum perkawinan yang ada di Indonesia. Hasil analisa menunjukkan bahwa dalil hukum yang digunakan Imam Ibnu Taimiyah yaitu merujuk pada ketentuan surat al-Maidah ayat 5. Pendapatnya yaitu laki-laki boleh menikahi wanita ahlul kitab yang tidak mengerjakan kesyirikan. Namun, wanita ahlul kitab yang perbuatannya terbukti syirik (mempersekutukan Allah), maka mereka masuk dalam cakupan makna surat al-Baqarah ayat 221, yaitu orang-orang musyrik yang dilarang untuk dinikahi. Adapun metode istinbÄá¹­ yang digunakan Imam Ibnu Taimiyyah yaitu metode bayyanÄ«,di mana, ketentuan surat al-Maidah ayat 5 bersifat khusus (khaá¹£) dan surat al-Baqarah ayat 221 bersifat umum (â€˜Äm). Untuk itu, ketentuan surat al-Maidah tentang bolehnya menikahi wanita ahlul kitab masih berlaku, tetapi ahlul kitab di sini dikhususkan hanya wanita Yahudi dan Nasrani yang tidak mengerjakan perbuatan syirik, atau sebelum terjadi penggantian dan pemalsuan ajaran kitab mereka.
Prosedur Poligami di Malaysia (Analisis AktaUndang-Undang Keluarga Islam Wilayah-Wilayah Persekutuan)
Authors: Ibrahim Muslim , Muhammad Safiq Imran Bin Samsudin Muhammad Safiq Imran Bin Samsudin
Published: November 2018

Prosedur poligami di Malaysia masih tidak seragam karena setiap negeri bagian masih menggunakkan prosedur yang tersendiri. Artikel ini membahas 2 hal, yaitu; bagaimana prosedur poligami di Malaysia khususnya di Wilayah Persekutuan dan bagaimana tinjauan hukum Islam terhadap perbedaan prosedur poligami yang ada di Wilayah Persekutuan dan negeri Terengganu. Artikel ini, menggunakan metode penelitian kepustakaan (library research) dengan mengkaji buku yang berisikan informasi mengenai prosedur poligami. Hasil pembahasan menunjukkan bahwa perbedaan prosedur poligami di Wilayah Persekutuan dan negeri Terengganu yang diatur dalam akta dan enakmen ini adalah pengaruh dan wewenang setiap negeri bagian bagi menetapkan pensyaratan dalam prosedur poligami di setiap negeri masing-masing. Prosedur poligami Wilayah Persekutuan mempunyai pensyaratan yang ketat untuk seseorang suami berpoligami dengan adanya izin istri sebelum permohonan poligami dilaksanakan sedangkan negeri Terengganu meringankan pensyaratan poligami dan tanpa perlu izin istri dan hanya perlu ke mahkamah syariâ€˜ah untuk mendapatkan borang permohonan poligami.
A Preliminary Scoping Review Study of the Progress of Social Media Adoption as an Educational Tool by Academics in Higher Education
Authors: Perez Eva , Brady Mairead
Published: November 2018

This paper presents a preliminary scoping review exploring the evidence landscape regarding academic staff experiences and perceptions of social media adoption as an educational tool in higher education. The goal of this paper is to examine 10 empirical studies of social media adoption in teaching and learning by academics in preparation for a proposal for a systematic literature review. Consequently, this scoping study assisted in the development of a review protocol which established the inclusion and exclusion criteria for conducting this systematic review at a future date. This paper will present the first stage of carrying out a systematic review: planning the review and presenting the results of the scoping study. The findings of this scoping study revealed that academics are slow in adopting social media within teaching and academics that have adopted the use of social media do so primarily for sharing relevant information and resources easily with students rather than for teaching purposes. Overall, the adoption of social media as an educational tool is faced with many challenges, such as cultural resistance, pedagogical issues, lack of institutional support and time investment. The results also indicate that teaching styles, demographic factors, privacy issues and previous experience can influence academic staff’s decision to adopt social media for teaching purposes.
Analysis of Tensions and Deformations of Fixing Supports of Photovoltaic Panels Installed on Rooftops
Authors: L. G. G. B. Ferreira  , J. L. Domingos  , A. J. Alves
Published: November 2018

This paper aim to analyze the exerted pressions by the  wind  on  photovoltaic  panels  installed  on  rooftops  as  well  as perform  analysis  of  tensions  and  deformations  ofsupporting aluminum   structures   for   photovoltaic   panels.   Computational simulations are performed in order to save time and obtaining the best  solution.  The  wind  intensity  and  directions  exert  pressures on the photovoltaic installation and its support structure resulting on  the  concentration  of  tensions  on  the  fixing  points on  both structural components and roof’s attachmentpoints. the generator.
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND LARVICIDAL ACTIVITY OF EDIBLE FERN (Diplazium esculentum (Retz.) Sw.) EXTRACT AGAINST Culex
Authors: Halimatussakdiah Halimatussakdiah , Amna Ulil , Wahyuningsih Puji
Published: November 2018

Mosquito is one of insects spreading the vector of serious diseases to human being through its bite such as Culex which spreads the vector of filariasis and brain inflammatory diseases. Some people have used plants as insecticides traditionally, such as fern (Diplazium esculentum (Retz.) Sw.). D. esculentum (Retz.) Sw. popularly known as edible fern which almost all Asian people, especially Indonesian consumed it as vegetable, and some people also used it for medicinal purposes. This study was performed to investigate the secondary metabolites from D. esculentum leaves and its larvicidal activity against Culex. The phytochemical screening was undertaken on the leaves and methanol extract of D. esculentum, the results showed the presence of alkaloids, steroids, phenols, and tannins on leaves, while methanol extract exhibited existence of steroids, saponins, phenols and tannins. Investigation of larvicidal activity of methanol extract was carried out against Culex larvaes for various concentrations which observed for 48 hours. Percentage of mortality was analyzed statistically using Bill Test method that showed active larvicidal activity with a LC50 value of 149.279 ppm. This study indicates that fern plant have the potential as larvicidal against Culex and need to perform the further research to develop the new natural insecticides.
WINSTON-BATAN: A SEISMOLOGICAL GROUND-MOTION ANALYSIS CODE
Authors: Yuliastuti Yuliastuti , A Euis Etty , Setiadipura Topan
Published: November 2018

A thorough understanding of an earthquake is very important to provide a descriptive knowledge and in the same time as a prescriptive knowledge for the future development. In particular, it is essential for site selection and structural design development of nuclear reactor and other critical facilities. Ground motion acceleration time history is an important raw information to understand the earthquake and specific geological condition of where the data is recorded. This paper presented the development of strong-motion analysis code, called Winston-BATAN, which able to interpret ground motion time history. The analysis scope of the code including the ground motion parameters such as peak ground acceleration, several additional seismic intensity parameters, strong motion duration, its frequency content via Fast Fourier Transformation and response spectra analysis. Being developed based on an open source Python programming language, Winston-BATAN is flexible for exploratory study to exploit the ground motion time history and easily improve to accommodate additional features. This code able to read input from PEER NGA type file or a simple time and acceleration data type of ground motion. Analysis results of Winston-BATAN shows a very good agreement compare to the results from the standard tools Seismosignal® 2018 Software, in addition flexibility of this code, in particular, to explore the response spectra from the ground motion time history is demonstrated.
Penelitian bioremediasi (ex-situ) tanah terkontaminasi limbah B3 yang mengandung logam berat
Authors: Rahayu Sri Pudji
Published: November 2018

Penelitian bioremediasi (ex-situ) tanah terkontaminasi limbah B3 yang mengandung logam berat
Disparitas Antar Wilayah Dan Provinsi Di Indonesia Sebelum dan Sesudah Otonomi Daerah
Authors: . Yanuar
Published: November 2018

Since the application of local autonomy in Indonesia in 2001, there have been more opportunities for the local governments to organize and manage their regions. It is meant to achieve regional development targets in improving the people's welfare and quality of life in accordance with eac region's and provinces in Indonesia before and after the application of local autonomy. It used the descriptive mertod with secondary data from 1991 up to 2010, and the Gini coeffient analys. This survey has concluded that the application of local autonomy have remained high,both among the regional and provincial levels. During the period of conducting this research, the local autonomy has not signitificantly secceedeed in reducing the desparity levels among regions and provinces in Indonesia.
A VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF DILTIAZEM IN RAW MATERIAL AND PHARMACEUTICAL DOSAGE FORM
Authors: Kumar B M S , Rajkamal B. , Chandramowli B.
Published: November 2018

The objective of this work is to develop and validate a reverse phase high performance liquid chromatography (RP-HPLC) method for the quantitative analysis of Diltiazem in bulk and pharmaceutical dosage form. Chromatographic analyses were performed on RP C-18 column with a mobile phase consisting of 0.01M ammonium acetate in water, methanol and acetonitrile in the ratio 700:240:60 at a flow rate of 1 mL/min. The Diltiazem was detected and quantitated using a photodiode array detector at a wavelength of 295 nm with a retention time of 11.57 min. The detector response was linear in the concentration of 20-60µg/ml, the respective linear regression equation being Y=3000181x+356238.2. The limit of detection and limit of quantification were 0.5µg/ml and 0.15µg/ml respectively. The assay of Diltiazem in bulk was found to be 99.85%. From the recovery studies it was found that about 101% on average of Diltiazem was recovered which indicates high accuracy of the method. The method was validated by determining its accuracy, precision and system suitability.The method fulfilled the requirements for reliability and feasibility for application to the quantitative analysis of Diltiazem in bulk and pharmaceutical dosage form.
PENYULUHAN RUMAH PANGAN MANDIRI DI NAGARI SILANTAI, KECAMATAN SUMPUR KUDUS, KABUPATEN SIJUNJUNG, SUMATERA BARAT
Authors: Efrizal Efrizal , Nurmiati Nurmiati , Periadnadi Periadnadi , Fernando Ando
Published: November 2018

Kegiatan ini bertujuan untuk berbagi pengalaman, penerapan ilmu, pengalian potensi diri dan pemecahan masalah yang terjadi di dalam masyarakat, terutama dibidang pertanian. Metoda yang digunakan adalah survey dan observasi, penyuluhan, percontohan (demplot) dan pelatihan langsung kelapangan. Berdasarkan survey dan data primer dari Nagari Silantai terlihat bahwa Nagari yang berada di Kecamatan Sumpur Kudus tersebut secara geografis berada pada posisi 0o26’49” LS dan 100o54’29” BT, dengan ketinggian dari permukaan laut sekitar 243 m dan curah hujan 300-4.000 mm/tahun. Dilihat dari topografi, Nagari Silantai memiliki permukaan tanah umumnya bergelombang dan berbukit, dengan luas wilayah sekitar 12.270 Ha. Dari hasil pengamatan di lapangan Nagari Silantai terdiri dari 4 Jorong yaitu Jorong Kinkin, Jorong Koto Tangah, Jorong Koto Ateh dan Jorong Ujung Koto. Ditinjau dari data masyarakat miskin, Nagari Silantai masih tergolong kepada masyarakat yang berekonomi miskin. Hal ini terlihat dari angka kemiskinan masyarakatnya sebesar 36,40%. Berdasarkan potensi daerah dan kondisi masyarakat di Nagari Silantai tersebut, maka kami terdorong untuk melakukan kegiatan penyuluhan rumah pangan mandiri di Nagari Silantai, Kecamatan Sumpur Kudus, Kabupaten Sijunjung, Sumatera Barat. Dari hasil kegiatan penyuluhan ini terlihat bahwa adanya sambutan dan antusias masyarakat untuk meningkatkan pengetahuan baik pada tingkat keluarga atau kelompok anggota masyarakat untuk mengembangkan kemandirian pangan, meningkatkan peran dan fungsi kelembagaan masyarakat Nagari dan menumbuh kembangkan kesadaran keluarga agar mau dan mempunyai motivasi dan mampu memanfaatkan lahan di wilayahnya untuk menjadi sumber pangan dan gizi.
Mucinous cystadenoma of the pancreas associated with pregnancy. Case report and review of the literature
Authors: Berevoescu Nicolae , Scăunașu Răzvan , Berevoescu Mihaela , Croitoru Alexandru
Published: November 2018

Objective. We present a rare pathology with uncommon onset. Background. Mucinous cystic pancreatic neoplasms (MCNs) are rare tumors, which generally occur in the fifth and sixth decades of women. Although some tumours are frankly malignant, all are in fact considered to be potentially malignant. Case report. We present the case of a 30-year-old patient, with a 16/11 cm tumor located in the pancreas body, which was diagnosed 8 months after birth. The preoperative assessment of the pancreatic lesion suggested the diagnosis of mucosal cyst neoplasm, without being able to determine its benign or malignant nature. Central pancreatectomy was performed with a good postoperative evolution. Histopathologic result was represented by mucinous pancreatic chistadenoma. Two years after surgical intervention, the patient presented no signs of recurrence or pancreatic (exocrine or endocrine) secretion deficiency. Conclusions. Preoperative imaging evaluation could be suggestive for mucinous cystic tumour, but this cannot specify however the nature of the tumor. The postpartum occurrence could establish a possible relationship between hormonal levels encountered during pregnancy and the development of this tumor, taking into considerations the ovarian-type stroma and the presence of hormone (estrogen and progesterone) receptors in this neoplasm. Central pancreatectomy without anastomosis preserves the functions of pancreas, and also decreases morbidity.
As-needed endotracheal suctioning protocol vs a routine endotracheal suctioning in Pediatric Intensive Care Unit: A randomized controlled trial
Authors: Lema Zuluaga Gloria Lucía , Fernandez Laverde Mauricio , Correa Varela Ana Marverin , Zuleta Tobón John
Published: November 2018

Objective: To compare two endotracheal suctioning protocols according to morbidity, days of mechanical ventilation, length of stay in the Pediatric Intensive Care Unit (PICU), incidence of VentilatorAssociated Pneumonia (VAP) and mortality.
Methods: A Pragmatic randomized controlled trial performed at University Hospital Pablo Tobón Uribe, Medellin-Colombia. Fortyfive children underwent an as-needed endotracheal suctioning protocol and forty five underwent a routine endotracheal suctioning protocol. Composite primary end point was the presence of hypoxemia, arrhythmias, accidental extubation and heart arrest. A logistic function trough generalized estimating equations (GEE) were used to calculate the Relative Risk for the main outcome.
Results: Characteristics of patients were similar between groups. The composite primary end point was found in 22 (47%) of intervention group and 25 (55%) children of control group (RR= 0.84; 95% CI: 0.56-1.25), as well in 35 (5.8%) of 606 endotracheal suctioning performed to intervention group and 48(7.4%) of 649 performed to control group (OR= 0.80; 95% CI: 0.5-1.3).
Conclusions: There were no differences between an as-needed and a routine endotracheal suctioning protocol. Trial Registration: ClinicalTrials.gov identifier: NCT01069185
Born to Donate: Proposals for “Savior Sibling” Regulation in Latin America
Authors: Zúñiga Fajuri Alejandra
Published: November 2018

A Savior Sibling is a child who is born to provide an organ, bone marrow or cell transplant, to a sibling that is affected with a fatal disease. There are created with the in vitro fertilization and pre-implantation genetic diagnosis and, in the process, the ethical standards for organ donation of children become less demanding. Therefore, we propose that the authorization of the technique considers, unavoidably, the opinion of an impartial third party that can guarantee the welfare of the child. We develop a critical analysis of the laws that regulate the creation of babies to serve as organ donors. We evaluate under what circumstances the organizations that play a part in the decisions, fulfill the ethical standards to allow the organ donation of children.
GASES SANGUÍNEOS Y LA ACIDOSIS METABÓLICA
Authors: ALARCÓN JAIRO
Published: November 2018

Una de las varias ayudas diagnósticas con las que se cuenta para abordar a los niños en las diferentes áreas de urgencias, hospitalización o cuidado intensivo, es la toma de gases sanguíneos, y de su interpretación, dependerán decisiones importantes, pues nos permite tener una idea sobre las condiciones en las que seencuentra la homeostasis del cuerpo, como se encuentra su equilibrio acido base, la función respiratoria y renal, entre otras. Se pretende que este tipo de revisionessistemáticas, permitan hacer un uso juicioso de esta ayuda diagnostica, que con el resultado de los mismos puedan ofrecer una aproximacion cercana a lo que estasucediendo en el niño, y que en esencia se utilice para la toma de decisiones que pueden en determinado momento definir el pronostico al paciente.
ÚLTIMAS TENDENCIAS EN EL MANEJO NUTRICIONAL DEL NIÑO CON ENFERMEDAD RENAL CRONICA:UN DESAFIO PARA TODOS
Authors: HERRERA ADELA
Published: November 2018

La enfermedad renal crónica (ERC) es un proceso fisiopatológico, cuya consecuencias la pérdida del número y funcionamiento de nefronas, desembocando a menudo en insuficiencia renal terminal, la que se considera un problema de salud pública en el mundo. La ERC se caracteriza también por la falla de la función en grados variables de intensidad con innumerables repercusiones derivadas de la acumulación de los productos finales del metabolismo con alteración del equilibrio hidroelectrolítico y acido base, trastornos hormonales y nutricionales. En estadíos avanzados se puede presentar prevalencia elevada de malnutrición en la ERC, estimada entre el 50-70%. La aparición de la Desnutrición en estos pacientes se da por numerosas anormalidades por lo que la intervención temprana en el manejo nutricional de estos pacientes, y el seguimiento de manera interdisciplinaria en los diferentes estadios, es esencial para contribuir con la disminución en la progresión de la enfermedad y mantener o mejorar el estado nutricional del individuo y favorecer el crecimiento. La prescripción del requerimiento de energía se debe dar el 100% de sus necesidades energéticas totales hasta el 150% por encima de su ingesta. Las recomendaciones proteica se sugiere un 100 al 140% si se encuentra en estadío 3 y del 100 al 120% en estadios 4 a 5. Las grasa: Se debe dar menos del 30% de las calorías totales con restricción de las grasas Saturadas y de las Trans Carbohidratos del 55-65% de la ingesta diaria. La fibra se recomienda dar 15- 25 gramos por día con mayor consumo de fibra soluble por su efecto metabólico Sodio entre 120 y 2300 miligramos por día según la edad del niño, Potasio dar restringido en caso de hiperkalemia. Las vitaminas dar una ingesta del 100% , las del complejo B , Acido Fólico, Vitamina C ,Calcio dar del 100 al 200% de las recomendaciones por edad del niño. El Fosforo se debe dar en niños con estadios de 3 a 5 un 100% de la recomendación y los líquidos se restringirá en niños con estadios 3 a 5 con oligoanuria.
CASO EXITOSO DE ADAPTACIÓN DE UN SISTEMA ALTERNO DE COMUNICACIÓN EN UN NIÑO CON INSUFICIENCIA MOTRIZ DE ORIGEN CEREBRAL
Authors: BETANCURT LIZETH , BURITICÁ ALEXANDER , BASTIDAS EDWIN , HOLGUÍN MARTHA SOFÍA
Published: November 2018

Introducción: La insuficiencia motriz de origen cerebral (IMOC) o parálisis cerebral es una de las discapacidades motrices con mayor repercusión en el proceso de escolarización. Objetivo: Describir el caso exitoso de la adaptación de un Sistema Alterno de Comunicación (SAC) en un niño con IMOC en proceso de inclusión escolar. Reporte de caso: Niño de 8 años, con IMOC tipo cuadriparesia espástica, con habla ininteligible por disartria espástica severa; asiste a educación especial/vulnerabilidad y recibe concepto favorable para inclusión en educación regular, siendo la mejor opción para su comunicación adaptar un SAC pictográfico. Discusión: Escolares con IMOC, requieren rediseño de condiciones que garanticen modelo de escuela inclusiva, aprendizaje, participación en la vida escolar y reconocimiento de la diversidad. Comunicarse con pares y adultos en un predictor de permanencia o deserción escolar. El uso de un SAC, facilita la inclusión en escuelas regulares, potenciando facilitadores y disminuyendo barreras del entorno.
La lectura comprensiva: un instrumento para aprender ciencias
Authors: Candela Rodríguez Boris Fernando
Published: November 2018

En las dos últimas décadas la comunidad del campo de la Educación en Ciencias ha llegado al consenso de que las estrategias de lectura comprensiva deben jugar un papel crítico dentro del currículum de las ciencias ya que éstas permiten vehiculizar el proceso de alfabetización científica y socialización de los estudiantes. Ahora bien, la literatura basada en la investigación sugiere un marco teórico que le serviría al profesor de ciencias para iluminar el diseño y la implementación de actividades de aprendizaje, las cuales tendrían a la lectura comprensiva de textos científicos como uno de sus elementos claves, dado que ésta es considerada un instrumento de aprendizaje y pensamiento. Así pues, a lo largo del cuerpo de este artículo se desarrollarán una serie de principios que subyacen a la enseñanza de las estrategias de lectura comprensiva tales como: seleccionar, planear, explicar y modelar las estrategias de lectura en cuesti´ón a los estudiantes singulares de un contexto particular.
Evolución del concepto de función como respuesta a problemas de la humanidad
Authors: Porras Torres Fabián
Published: November 2018

Este estudio se apoya en el modelo de Stephen Toulmin para hacer un seguimiento a la evolución del concepto de función, desde la época antigua hasta cuando el concepto de función adquiere su estatus de objeto matemático, pasando por la edad media e identificando los problemas que dieron lugar a las diversas variaciones conceptuales que derivaron en el concepto como se conoce actualmente.
La filosofía como práctica cultural educativa
Authors: Cárdenas López Gustavo Adolfo
Published: November 2018

La pregunta acerca de ¿qué es la filosofía? ha sido respondida de múltiples formas a lo largo de la historia, como también se ha respondido de muchas maneras la pregunta ¿qué es lo que llamamos cultura? Sin embargo, poco se ha hablado en torno a la relación que existe entre filosofía y cultura, es decir, de la filosofía como una actividad cultural del pensamiento. La filosofía debe superar el academicismo donde se ha visto enclaustrada, superar la institucionalidad, romper los muros que la encierran y establecer nuevamente una conexión con la cultura de la que no solo se ha apartado, sino de la cual no parece ya ser parte, ignorando que es justamente esa conexión con la cultura lo que hace que un pensamiento pueda ser considerado como filosófico o no. En este panorama entra a jugar un papel determinante la educación, la cual, así como puede fortalecer los poderes hegemónicos, emergiendo desde abajo, puede romper con todo orden establecido.