bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure-based Drug Design, ADME and Molecular Docking analyses of anti-viral agents against SARS-CoV-2 virus, Zika virus and Hepatitis C virus
Authors: Solo Peter , Zeliang Sangdintuile , Lohe Muluvelu , Neikha Avünü , Jamir Akumsunep
Published: July 2023

Computer-aided drug design has been taking an increasing role in the field of modern drug discovery.  These in silico computational methods are cost-effective, reduce the use of animal models in pharmacological research, and can be used to study pathogenic organisms without the need for any facilities. Based on the structure of known anti-viral agents, a total of 812 ligands have been designed. All ligands were screened for drug-likeness based on Lipinski rule of five. A database of ligands was constructed and in silico docking analyses were performed using MOE 2015.10 program against three selected viruses, viz., Zika virus, Hepatitis C virus and SARS-CoV-2 virus. Ligand 93 (-8.4469 kcal/mol) and ligand 123 (-8.3609 kcal/mol) were identified to be having higher docking scores as compared to the native ligand 6T8 (-8.2839 kcal/mol) and could be considered potential candidates for further studies in anti-viral drugs against Zika virus. Ligands 153 (-10.3108 kcal/mol), 63 (-9.9968 kcal/mol), 621 (-9.8700 kcal/mol), 31 (-9.5001 kcal/mol) and 779 (-9.3874 kcal/com) were identified as the top five binding ligands, and have docking scores much higher than the reference native ligand K4J (-8.9037 kcal/com). All these ligands can be potent candidates for anti-viral research against Hepatitis C virus. Ligand 798 (-8.0957 kcal/com) and ligand 63 (-8.0778 kcal/com) have higher docking scores as compared to the reference native ligand X77 (-8.0689 kcal/mol), they also interact with the catalytic dyad at the active site of the target protein and can be considered as possible candidates for studies in anti-viral drugs against SARS-CoV-2.

Keywords: Computer-aided drug design, ADME, Molecular Docking analyses, anti-viral agents, Sars-CoV-2 virus, Zika virus, Hepatitis C virus
As percepções das perdas ocupacionais de mulheres cuidadoras dos parceiros tetraplégicos
Authors: Moraes Carla Viana de , Arantes Israel da Silva , Alves Vittória de Braz Oliveira , Resende Bárbara Duarte , Gomes Helena dos Santos Castro , Pereira Ruth Fernandes
Published: July 2023

Introdução: A tetraplegia caracteriza-se por uma desordem na estrutura da medula espinhal na altura cervical e exige cuidados que vão de aspectos físicos a cuidados mentais e sociais. Estudos comprovam que cuidadores são, na maioria, familiares do sexo feminino. A mulher cuidadora de seu cônjuge passa a sofrer com sobrecargas e perda de atividades matrimoniais. Objetivo: Compreender a percepção das mulheres principais cuidadoras de seus parceiros, que possuem tetraplegia decorrente de uma lesão medular, sobre as perdas ocupacionais. Metodologia: Estudo descritivo exploratório qualitativo, realizado através de questionário sociodemográfico e entrevistas semi-estruturadas, com amostra por saturação dos dados. Foram entrevistadas oito cuidadoras que aceitaram participar da pesquisa e assinaram o Termo de Consentimento Livre e Esclarecido (TCLE). As entrevistas foram gravadas, transcritas e os dados analisados utilizando-se a análise temática de Bardin. Resultados: As entrevistadas informaram possuir idade entre 28 e 55 anos, sendo a maioria de religião evangélica e baixa renda. Relataram sobrecarga devido à rotina de trabalho integral e desvalorização do seu serviço, apresentando prejuízo no papel de esposa e realização do autocuidado. Considerações finais: As cuidadoras entrevistadas perceberam perdas nos papeis de esposa e no autocuidado, apresentando uma rede de apoio insuficiente, demandando maior participação do sistema de saúde, necessitando de implementação de novas políticas públicas.
Features of Legal Regulation of the Certain Types of Inheritance Agreements
Authors: Kolesnik I. V. , Rudik I. E.
Published: July 2023

Introduction. In the Inheritance Law doctrine much attention is paid to the Inheritance Agreement construct as a universal tool for planning the inheritance procedure. However, the content of the Inheritance Agreement depends on the purpose of the agreement. In the present article, the features of each type of the Inheritance Agreement are defined. The aim of the study is to determine the legal regulatory specifics of the relationships being the subject of different types of the Inheritance Agreements and justify the need to apply a particular method of defending the interests of the Parties thereto.

Materials and Methods. The social relationships arising from entering, executing and terminating the certain types of the Inheritance Agreements are the object of the present study. The methodological basis of the research includes the general scientific methods: formal-logical analysis, structural-functional and induction methods. From among the specific scientific methods, the legalistic and comparative-legal methods have been used.

Results. Based on the purpose of the Inheritance Agreement, five types of this legal construct have been distinguished: the Inheritance Agreement designated for a testator to receive income during his lifetime from the after death descent of inheritance; the one used for financing the implementation of the important testator’s interests after his death; the agreement concluded to encourage the heir’s certain behavior before and (or) after testator’s death, including management of a testator's property; the Inheritance Agreement protecting the will of a testator from being contested by heirs; the Matrimonial Inheritance Agreement. Each type has the features of legal regulation expressed in the ways of defending the rights and interests of the parties to the agreement.

Discussion and Conclusions. The analysis of the implementation efficiency of the considered types of the Inheritance Agreements in terms of achieving their Parties’ goals, allowed formulating the following conclusions. For ensuring fulfillment of a testator’s will after his death, it is necessary to allow keeping the record of the inheritance acquiring conditions during the period established for the accession to the heirship. To strengthen protection of a testator’s counterparty in the compensatory contracts, it is necessary to allow encumbering the future inheritance with pledge; impose on a testator the obligation to inform a heir about the alienation of property, being an object of an agreement and reimburse him the incurred expenses; recognise the right of a heir for reimbursement of all the losses incurred due to relying on a testator’s promise to transfer to him the property after death.
Educational Resources Developers’ Copyright
Authors: Kasyanenko T. S. , Alekseeva A. P.
Published: July 2023

Introduction. Development of digital technologies, expansion of the spheres of distant learning implementation in the context of providing the educational services has resulted in creation and location of large amount of informational content at the open educational resources and institutional websites with access restricted for the external users. As consequence, there arise issues of authorship and copyright holding of the above-mentioned content, the limits of using the intellectual activity results of the authors of such content, distribution of remuneration received for its commercial use, as well as protection of subjects’ copyright whenever it is violated.

Materials and Methods. The present study is based on the works of Russian and foreign researchers on copyright, on provisions of the Russian Federation Civil and Labor Law, as well as on the legislation of foreign countries. General scientific and specific scientific methods were used, such as the method of comparative legal studies, which allowed finding out approaches for solving the set forth problems in the frame of the other jurisdictions.

Results. The conducted research shows that the problem of unlawful use of the educational content and protection of the rights of the content authors and copyright holders is widely spread and is especially relevant for the open educational resources. The authors of the present article have come to the conclusion that educational online content should be qualified as a complex piece of work and at the same time as a computer software and a unique database. The limits of free use of such a product should be specifically stipulated, i.e. for personal use, for non commercial use. For settling disputes between the authors and educational institutions, it is proposed to specify in an employment contract the types of pieces of work that are considered institutional ones, and to determine the conditions for using them among the parties.

Discussion and Conclusions. The investigated problems of creating and locating the large informational-educational content, of using and processing the results of intellectual activity of the authors of such content, distributing the remuneration received for its commercial use, as well as protecting the rights of subjects in case of violation, have great practical importance, because the findings can be applied to solving the problems of exclusive ownership of the institutional pieces of work.
INSURGENCY AND TERRORISM IN AFRICA. MAIN LINES OF ACTION OF THE EUROPEAN UNION. CASE STUDY: CENTRAL AFRICAN REPUBLIC, MALI AND NIGER / INSURRECTION ET TERRORISME EN AFRIQUE. PRINCIPALES ORIENTATIONS DE REPONSE DE L'UNION EUROPEENNE. ETUDE DE CAS: REPUBLIQ
Authors: STANCIU Robert-Ionuț
Published: July 2023

This article examines the main causes of insecurity on the African continent by attempting to identify the structural factors. Starting from these, the study examines and proposes a series of generic EU action lines for an integrated response. The work aimed to answer the following questions: What are the structural factors of insecurity in Africa? What lines of action should the European Union adopt? Is the action in the security sector sufficient? The methodology used was the comparative analysis of similar phenomena in the three mentioned countries. Process tracing and document analysis techniques were also used to determine causality and similarities. The findings indicate that violent extremism, inter- and intra- community conflict, climate change, population growth and poor governance are exacerbating instability and fragmentation on the African continent. Moreover, armed conflicts have become internationalized due to the involvement of external actors such as Russia and China, even if their strategies are different and complementary in nature. In this context, the main axes of the European Union's response must be subordinated to diplomacy and political dialogue, support for socio-economic development and the strengthening of the security sector. These measures should be complemented by coordinating the actions of like-minded actors and articulating appropriate strategic communication actions.
DEMOCRATIC ROTATION, AN ALTERNATIVE TO POWER SHARING IN THE DEMOCRATIC REPUBLIC OF CONGO / LA DEMOCRATIE ROTATIVE, UNE ALTERNATIVE AU POWER SHARING EN REPUBLIQUE DEMOCRATIQUE DU CONGO
Authors: ZAGABE KATAMBWE Christophe
Published: July 2023

In this article, we outline the history and evolution of the Congolese people from their origins to independance with the State preceding the Nation. Concerning democracy accession to legislative power after independance, there is in DRC a curious rotation of political transition beyond various regime changes and arrangements of Power sharing occurred between community groups. However, there were noises, quarrels and or violences between linguistic socio-anthropological actors on the legitimacy of power, access to the presidential chair, which gave rise to inter group conflicts till the country is divided into three community groups : the Luba community of Félix Tshisekedi from CACH-USNA at the center of power, the Swahili community of Joseph Kabila from AMP-FCC who genially handed over power but also on its periphery, and the Kongo-Ngala community of Martin Fayulu from LAMUKA to the outskirts. The concept « Majority » has cleverly been exploited by those in power in order to subjugate and or exclude their protagonists. In the context of this article, we finally propose the model of Rotary Democratic called « Inculturated Democracy » by Isidore Ndaywel in « Congolese historiography, an essay of achievement ». An alternative model to « Power sharing method » generally presented as democracy model in which the group element constitutes an important criterium of participation in term of access to political power, mainly the legislative power and its executive.
THE CONSTITUTIONAL IMPORTATION AND THE POLITICAL MODERNIZATION OF THE ROMANIAN STATE / L’IMPORTATION CONSTITUTIONNELLE ET LA MODERNISATION POLITIQUE DE L’ÉTAT ROUMAIN
Authors: CRĂCIUN-CHIVEREANU Claudia-Elena
Published: July 2023

This article has as its starting point the genesis of Romanian constitutionalism. Developed according to the Belgian model, the Constitution of 1866 allowed the birth of a democratic system of government and consolidated the autonomy of Romania, in the context where, after the abdication of Prince Alexandru Ioan Cuza, there was an inherent need for governmental stability. However, the decision to adopt a prestigious constitutional model was guided by the idea of international legitimacy. The predominantly liberal character of the Belgian Constitution of 1831 influenced the process of drafting fundamental laws in several European states, not only in Romania (Greece, Italy, Prussia, etc.). The constitutional import process is inevitable, but extremely difficult and rarely impossible. The inevitability of this process stems from the fact that overarching constitutional ideas and mechanisms are generally limited. This type of transfer occurs when constituent assemblies face a particular problem and choose to focus on already functioning constitutions.
THE IMPORTANCE OF HIGHER EDUCATION ON ECONOMIC GROWTH
Authors: COHEN Avraham
Published: July 2023

It is very important for countries to stimulate their economic prosperity and reduce poverty. While it is commonly accepted that education of all forms enhances economic performance of a country, yet the question of which level of education, secondary or tertiary, is more important to fuel the economy is not conclusively answered. The finding in Avraham Cohen’s PhD thesis is that education, as measured by published research, is strongly associated with Artificial Intelligence index of countries. Also, he found that AI is strongly associated with GDP. His findings encourage the idea that higher education, which is needed for Artificial Intelligence (AI), will be a dominant factor for economic growth in general; hereby, policy makers should invest in higher education to ensure economic affluence. Enrollment rates for higher education in Sub-Saharan Africa are by far the lowest in the world and the academic research output in the region is among the world’s lowest. Because of a belief that primary and secondary schooling are more important than tertiary education for poverty reduction, the international development community has encouraged African governments’ relative neglect of higher education. Using methodology of fuzzy logic-based soft regression, this study challenges these beliefs and demonstrates that economic growth is almost exclusively determined by higher education. Also, the importance of higher education relative to secondary education is more so in recent years relative to a decade or two ago. Motivated by this finding, I propose to find the right branch of higher education for every country based on its economic competitive advantage that will impact its economic growth best.
HOW MUTUALLY HURTING STALEMATES BECOME ESSENTIAL IN PEACE-BUILDING EFFORTS. THE CASE OF LIBERIA
Authors: HERȚA Laura Martia , ALDEA Claudiu-Bogdan
Published: July 2023

The paper focuses on two concepts developed by William Zartman, namely ”ripe moments” and “mutually hurting stalemates”. Basically, the concepts tackle the idea of certain proper moments for the beginning of peace talks when the parties to the conflict believe that they are trapped in a painful impasse which no longer brings them victory. Our paper aims to show that hurting stalemates are sometimes the adequate starting point for peace-building efforts as well, not only for starting negotiations, and to apply this on the case of Liberia. The paper is organized around the following research questions: Is the hurting stalemate a military deadlock? Is a similar painful deadlock a good starting point for building sustainable peace in post-conflict societies?
Multigram synthesis of stellane 1,5-dicarbonic acid as a key precursor for the ortho-benzene mimics
Authors: Smyrnov Oleh , Melnykov Kostiantyn , Rusanov Eduard , Suikov Sergey , Pashenko Olexandr , Fokin Andrey , Volochnyuk Dmytro , Ryabukhin Serhiy
Published: July 2023

Herein we present previously unavailable C(sp3)-rich polycyclic hydrocarbon scaffolds which have a potential to become valuable tools in medicinal chemistry and crop science as saturated bioisosteres of benzenoids. We have developed a scalable protocol (up to 50 g from a single synthetic run) for the synthesis of tricyclo[3.3.0.03,7]octane (bisnoradamantane or stellane) 1,5-dicarbonic acid derivatives. X-ray crystallographic analysis of the stellane 1,5-dicarbonic acid dimethyl ester has revealed that this scaffold is an optimal saturated isostere for ortho-disubstituted benzene where substituents exhibit the in-plane topology. The synthetic protocol is based on the oxidative cyclization of dimethyl octahydropentalene-2,5-dicarboxylate (DMOD) through lithiation followed by I2 oxidation. The reaction outcome is determined by the stereochemistry of the substrate. While the endo,endo cis-DMOD, exclusively gives the "unwanted" Claisen cyclization product the exo,endo cis- and exo,exo cis- stereoisomers afford the desired stellane 1,5-dicarbonic acid dimethyl ester quantitatively. DFT computations have revealed that the reaction proceeds via the dianion of dimethyl octahydropentalene-2,5-dicarboxylate, which undergoes SET oxidation by I2 to form a radical anion. The subsequent cyclization followed by a second SET oxidation gives desired stellane derivative.
Expanding Bioactive Fragment Space with the Generated Database GDB-13s
Authors: Buehler Ye , Reymond Jean-Louis
Published: July 2023

Identifying innovative drug-like small molecules is critically important in medicinal chemistry to address new targets and overcome limitations of classical molecular series. By deconstructing molecules into ring fragments (RFs, ring and ring-adjacent atoms) and acyclic fragments (AFs, only acyclic atoms), we find that molecules in public databases of drug-like compounds (ZINC, PubChem) and natural products (COCONUT) mostly consist of RFs and AFs up to 13 atoms, and that many RFs and AFs are enriched in bioactive compared to inactive molecules in ChEMBL. We then search the 28,246,012 RFs and 2,640,023 AFs in the generated database GDB-13s (99,394,177 molecules up to 13 atoms following simple functional group and ring strain criteria) for subsets resembling ChEMBL bioactive RFs and AFs. Many of these RFs and AFs are structurally simple, have favorable synthetic accessibility scores, and represent opportunities for synthetic chemistry to contribute to drug innovation in the context of fragment-based drug discovery.
СИНТЕЗ И КРИСТАЛЛИЧЕСКИЕ СТРУКТУРЫ КОМПЛЕКСОВ ЕВРОПИЯ С ПРОСТРАНСТВЕННО-ЗАГРУЖЕННЫМ ArBIG–BIAN ЛИГАНДОМ
Authors: Соколов В.Г. , Лукина Д.А. , Скатова А.А. , Федюшкин И.Л. , Баранов Е.В. , Кискин М.А.
Published: July 2023

Восстановление ArBIG-bian (ArBIG-bian = 1,2-бис[(2,6-дибензгидрил-4-метилфенил)-имино]аценафтен) избытком металлического европия в dme и кристаллизация из смеси tmeda/thf приводит к комплексу европия(II) [(ArBIG-bian)Eu(thf)2] (1), содержащему дианион дииминового лиганда. Взаимодействие 1 с 0.5 мол. эквивалента тетраметилтиурамдисульфида в dme проходит с окислением лиганда до анион-радикала и образованием дитиокарбаматного производного [(ArBIG-bian)Eu{S2CNMe2}(dme)] (2). Вновь полученные соединения 1 и 2 охарактеризованы методами ИК-спектроскопии и элементным анализом. Молекулярные структуры комплексов 1 и 2 установлены методом РСА.
ESTRATÉGIAS NÃO FARMACOLÓGICAS NO CONTROLE DA DOR CRÓNICA EM ADOLESCENTES
Authors: Cruz Sofia , Marques Goreti , Silva Sofia , Fernandes Rita , Barcelos Olívia
Published: July 2023

Introdução: O diagnóstico de uma doença crónica tem um profundo impacto na vida do adolescente e da sua família. A dor está muitas vezes associada à doença e/ou a procedimentos inerentes a toda a sua trajetória. O Enfermeiro Especialista em Saúde Infantil e Pediátrica deve assumir a dor do adolescente como um foco importante de atenção, adotando todas as estratégias para a sua prevenção e controle. Objetivos: Identificar produção científica relativa às estratégias não farmacológicas no controle da dor crónica em adolescentes. Metodologia: Revisão Integrativa da Literatura efetuada nas bases de dados: CINAHL Complete; MEDLINE Complete; Nursing & Allied Health Collection: Comprehensive; Cochrane Central Register of Controlled Trials; Cochrane Database of Systematic Reviews e MedicLatina, disponíveis no motor de busca EBSCO, publicados entre 2012 e 2022. A seleção e análise de relevância dos artigos foi efetuada pelos revisores de forma independente. Resultados: Dos 364 artigos iniciais foram selecionados 8 artigos, segundo critérios previamente definidos. Constatou-se que, as estratégias do Enfermeiro Especialista em Saúde Infantil e Pediátrica são essencialmente dirigidas aos adolescentes e pais, no contexto domiciliário e com recurso a tecnologias. São ainda apresentadas estratégias focadas no adolescente em contexto clínico e reforçada a influência de suporte externo, através de coach online. Conclusão: É fundamental investir na formação dos profissionais, sensibilizando-os para a implementação de estratégias não farmacológicas no alívio da dor crónica no adolescente, assim como a necessidade de adequação das estratégias às novas tecnologias.
O uso de paratextos em O Regicida
Authors: Santos Katrym Aline Bordinhão dos
Published: July 2023

Considerando que um processo de leitura que seja focado na análise de estratégias de escrita colabora no entendimento da organização de um texto, perspectivas com sua publicação e a multiplicidade de significados que ele pode conter, o que inclui a abordagem dos paratextos, objetiva-se analisar alguns elementos paratextuais em O Regicida, de Camilo Castelo Branco, romance histórico e que, justamente por isso, apresenta uma série desses recursos. Para tanto, nos concentramos nas definições de Gérard Genette sobre prefácio e notas, verificando como aparecem na obra, concluindo que há uma utilização muito profícua deles para o caráter histórico desse romance camiliano.
Os muitos regozijos possíveis de Camilo Castelo Branco (Amor de Perdição no século XXI)
Authors: Harmuch Rosana Apolonia
Published: July 2023

Este texto toma duas questões como pontos de partida. A primeira é o apagamento da Literatura nos documentos oficiais que regulamentam a Educação Básica no Brasil. A segunda é o insistente atrelamento, oriundo do senso comum, entre ensino de Literatura e gosto pessoal. Os dois pontos contribuem para o menosprezo dos estudos literários e, portanto, para um enaltecimento do que pode ser chamado de “impressões de leitura”. As obras literárias selecionadas por algumas universidades para seus vestibulares são, neste texto, entendidas como formas de resistência a esses dois pontos. Para o reconhecimento da importância dessas listas, foi tomado como objeto de estudo o caso específico do romance Amor de perdição, elencado pela Universidade Estadual de Londrina (UEL), nos anos de 2019 a 2022. Para a reflexão sobre como a obra é efetivamente cobrada, foram analisadas duas questões do vestibular de 2021.
Le monde à l’envers: o universo carnavalesco em Eusébio Macário, de Camilo Castelo Branco
Authors: Mendes Karla Renata
Published: July 2023

A vasta obra de Camilo Castelo Branco é quase sempre dividida entre duas categorias: as novelas passionais e as satíricas. Pertencente à segunda, o livro Eusébio Macário (1879) propõe um arrojado diálogo paródico com o Naturalismo, movimento literário que emergia contemporâneo ao escritor. Estabelecendo um diálogo crítico com a nova corrente, Camilo tensiona, através da paródia e do exagero, questões caras ao Naturalismo, tais como o cientificismo, a animalização e a crítica à corrupção, ridicularizando-as, sobretudo, na figura do protagonista, que dá título à obra. Assim, procura-se explorar como, a partir desse elemento satírico, cria-se um mundo carnavalizado, sem hierarquias, e arquitetado para abrigar personagens que encarnavam o ridículo e a crítica à nova estética.
O julgamento de Maria no Matricídio sem exemplo, de Camilo Castelo Branco
Authors: Parra Filho Raphael Hernandes , Pavanelo Luciene Marie
Published: July 2023

O objetivo deste artigo é apresentar uma análise da terceira edição de Maria, não me mates, que sou tua mãe!, folheto de cordel cuja primeira edição fora publicada por Camilo Castelo Branco em 1848. Apesar de ter sido um grande sucesso de público na época, a obra recebeu pouca atenção da crítica especializada, sendo mencionada apenas como a primeira narrativa do autor. Neste trabalho, apontaremos algumas especificidades da terceira edição da obra, intitulada Matricídio sem exemplo, hoje praticamente desconhecida.
TRABAJADORES DE SALUD Y PRECARIEDAD LABORAL EN TIEMPOS DE PANDEMIA: LOS CASOS DE BRASIL Y PERÚ
Authors: Bordais Jhomelin Milagros Flores
Published: July 2023

O acontecimento global da pandemia de Covid-19 obrigou uma grande parte da população a adotar medidas de confinamento e de distanciamento social para travar a propagação e o avanço do vírus. No entanto, nem todos tiveram o privilégio de paralisar as suas atividades; os trabalhadores do setor da saúde, da alimentação e das atividades essenciais continuaram a trabalhar e a prestar serviços no meio da emergência sanitária causada pelo novo coronavírus. Neste contexto, a chegada da pandemia trouxe consigo desafios que contribuíram para a deterioração do sistema de saúde e para o agravamento das precárias condições de trabalho dos profissionais de saúde. O presente trabalho é um ensaio empírico de natureza qualitativa que será abordado através dos instrumentos metodológicos da pesquisa bibliográfica e documental. O objetivo do ensaio se concentra em descrever e analisar o contexto da situação de emprego dos profissionais de saúde do Brasil e do Peru em tempos de pandemia por Covid-19. Para o efeito, aborda-se a situação da pandemia e analisam-se as dimensões da precariedade do trabalho dos profissionais de saúde em plena crise sanitária. Argumenta-se que, com a chegada da pandemia, as condições precárias de trabalho dos profissionais de saúde se agravaram. Isso se deve, especificamente, à infraestrutura deficiente em que exercem suas atividades, à falta de equipamentos de proteção individual (EPIs) e, sobretudo, à ausência de medidas de proteção à sua saúde e integridade. Assim, é evidente o abandono a que estes trabalhadores estão atualmente sujeitos por parte do setor da saúde, pelo que se sugere a melhoria das políticas laborais no sentido de reforçar o direito dos trabalhadores da saúde a um ambiente de trabalho seguro.
ELOS ENTRE BRASIL E HAITI POR MEIO DO FUTEBOL: UMA ANÁLISE DO FILME “O DIA EM QUE O BRASIL ESTEVE AQUI”
Authors: Reis ConfiguraçõesRodrigo Nascimento
Published: July 2023

A partir do documentário “O dia em que o Brasil esteve aqui”, o artigo busca encontrar os elos entre Brasil e Haiti que possibilitaram o futebol brasileiro ser utilizado como ferramenta de soft power (Nye, 2004). O filme trata da visita da seleção brasileira ao Haiti em agosto de 2004 para o “Jogo da Paz”, um episódio ocorrido em função Missão de Paz das Nações Unidas no Haiti (MINUSTAH) comandada pelo Brasil. Nesse sentido, como estratégia metodológica, utiliza-se as categorias de Vuving (2009) em que o poder brando se traduz em benignidade, brilho e beleza. Com essas categorias, observamos que os elos históricos entre ambos países permitem caracterizar a seleção brasileira como bon bagay, extraordinária e detentora do jogo bonito. Em conjunto, as características mostram a força do futebol brasileiro como ferramenta de poder no cenário internacional e como este foi capaz de pavimentar caminho para uma aproximação dos haitianos à missão de paz da ONU.
Prevenção do uso de drogas de abuso por caminhoneiros
Authors: Soares Deliane dos Santos , Castro Ellen Kricia Duarte Ribeiro , Nascimento Fabiane Corrêa do , Costa Jacqueline Oliveira Miranda da , Paiva Edson Bruno Campos , Santos Pamela Farias , Vasconcelos Cristiane Mara Silva de , Barra Isabel Pires , Vieira Zonilce Brito , Silva Flávia Garcez da , Reis Elaine Cristiny Evangelista dos
Published: July 2023

Trata-se de um material estruturado para trazer informações para os caminhoneiros que trafegam nas rodovias brasileiras, sobre os efeitos e riscos do uso substâncias, como: Anfetaminas, Cocaína, Maconha, Álcool, Tabaco e Inalantes, abordando o processo de dependência, os efeitos no cérebro, os danos a saúde bucal e problemas legais. O material foi desenvolvido por uma equipe multiprofissional do Programa de Pós-Graduação da Residência Multiprofissional em Estratégia Saúde da Família da Universidade Federal do Oeste do Pará e supervisionado por docentes da instituição.
İVAN ZAHAROVİÇ SURİKOV’UN ŞİİRLERİNDE YOKSUL KÖYLÜ TİPİ
Authors: ILICA Sevgi
Published: July 2023

İvan Zaharoviç Surikov (1841-1880), XIX. yüzyılın ikinci yarısında ön plana çıkan Rus köylü şairlerinin en önemlilerinden biridir. Köyde doğan ve sekiz yaşında ailesiyle birlikte Moskova’nın taşra bölgesine yerleşen şair, hayatı boyunca hiç sistematik eğitim almaz. Okula gitme şansı olmayan Surikov, okuma yazmayı tanıdıklarından öğrendikten hemen sonra edebiyata ve şiire ilgi duymaya başlar. Eline geçen tüm kitapları hevesle okuyan Surikov küçük yaşlardan itibaren amatör şiirlerini kaleme alır. Otoriter baba baskısı, geçim sıkıntısı, vakit yetersizliği ve fiziksel koşulların elverişsizliğine rağmen edebiyat camiasına girmeyi başarır. Surikov’un şiirlerinde serf Rus köylülerinin gerçekçi tabloları yer alır. Şair, Rus köylülerinin gerek köylerinde gerekse şehirlerde yaşadıkları zorlukları dile getirir. Surikov'un şiirleri, Rus köylüsünün sınıf mücadelesini ve ekonomik adaletsizliği son derece gerçekçi ve otobiyografik bir tarzda betimlemesi nedeniyle edebî olmanın ötesinde, tarihsel ve sosyolojik açıdan da büyük bir öneme sahiptir. Çalışmada, Surikov’un 1865-1875 yılları arasında kaleme aldığı şiirlerinde yer alan yoksul köylü tipinin incelenmesi amaçlanmıştır. Şairin yaşam öyküsüne yer verilmiştir. Surikov’un bahsi geçen tipolojideki şiirleri tarihsel eleştiri yöntemiyle ve betimleyici bir üslupla ele alınmıştır. Sonuç olarak, şairin Rus köylülerinin sınıf mücadelesini ekonomik, sosyolojik ve tarihsel açılardan gerçekçi bir şekilde aktardığı gösterilmiştir.
A Review on Anaerobic Co-Digestion with a Focus on the Microbial Populations and the Effect of Multi-Stage Digester Configuration
Authors: Rabii Anahita , Aldin Saad , Dahman Yaser , Elbeshbishy Elsayed
Published: July 2023

Recent studies have shown that anaerobic co-digestion (AnCoD) is superior to conventional anaerobic digestion (AD). The benefits of enhanced bioenergy production and solids reduction using co-substrates have attracted researchers to study the co-digestion technology and to better understand the effect of multi substrates on digester performance. This review will discuss the results of such studies with the main focus on: (1) generally the advantages of co-digestion over mono-digestion in terms of system stability, bioenergy, and solids reduction; (2) microbial consortia diversity and their synergistic impact on biogas improvement; (3) the effect of digester mode, i.e., multi-stage versus single stage digestion on AnCoD. It is essential to note that the studies reported improvement in the synergy and diverse microbial consortia when using co-digestion technologies, in addition to higher biomethane yield when using two-stage mode. A good example would be the co-digestion of biodiesel waste and glycerin with municipal waste sludge in a two-stage reactor resulting in 100% increase of biogas and 120% increase in the methane content of the produced biogas with microbial population dominated by Methanosaeta and Methanomicrobium.
Robust Self-Tuning Control Design under Probabilistic Uncertainty using Polynomial Chaos Expansion-based Markov Models
Authors: Du Yuncheng , Budman Hector , Duever Thomas
Published: July 2023

A robust adaptive controller is developed for a chemical process using a generalized Polynomial Chaos (gPC) expansion-based Markov decision model, which can account for time-invariant probabilistic uncertainty and overcome computational challenge for building Markov models. To calculate the transition probability, a gPC model is used to iteratively predict probability density functions (PDFs) of system’s states including controlled and manipulated variables. For controller tuning, these PDFs and controller parameters are discretized to a finite number of discrete states for building a Markov model. The key idea is to predict the transition probability of controlled and manipulated variables over a finite future control horizon, which can be further used to calculate an optimal sequence of control actions. This approach can be used to optimally tune a controller for set point tracking within a finite future control horizon. The proposed method is illustrated by a continuous stirred tank reactor (CSTR) system with stochastic perturbations in the inlet concentration. The efficiency of the proposed algorithm is quantified in terms of control performance and transient decay.

 
The Role of pH, Ionic Strength and Monomer Concentration on the Terpolymerization of 2-Acrylamido-2-methylpropane Sulfonic Acid, Acrylamide and Acrylic Acid
Authors: Scott Alison J. , Duever Thomas , Penlidis Alexander
Published: July 2023

The current study examines the effects of important factors (namely, pH, ionic strength and monomer concentration) on the terpolymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm) and acrylic acid (AAc). A good understanding of how these factor levels affect terpolymerization reactivity ratios, and terpolymer composition, microstructure and molecular weight paves the way for the synthesis of custom-made polymers for specific applications. For the range of conditions studied, ionic strength has the greatest influence on reactivity ratios; results indicate that cross-over behavior exists for AMPS-based reactivity ratios. No clear correlation is observed between pH and reactivity ratio estimates (for 5 ≤ pH ≤ 9), but parameter estimation results suggest that the incorporation of acidic comonomers (AMPS and AAc) is affected by pH within this range. Finally, monomer concentration has a dominant impact on molecular weight averages, even when other factors are varied.
Social Capital, Institutional Rules, and Constitutional Amendment Rates
Authors: Blake William , Cozza Joseph , Armstrong David , Friesen Amanda
Published: July 2023

Why are some constitutions amended more frequently than others? The literature provides few clear answers, as some scholars focus on institutional factors, while others emphasize amendment culture. We bridge this divide with new theoretical and empirical insights. Using data from democratic constitutions worldwide and US state constitutions, we examine how social capital reduces the transaction costs imposed by amendment rules. The results indicate that constitutional rigidity decreases amendment frequency, but group membership, civic activism, and political trust can offset the effect of amendment rules. Our findings have important implications for scholars in public law, constitutional and democratic theory, and social movements.
NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages
Authors: Dodd William S. , Patel Devan , Motwani Kartik , Lucke-Wold Brandon , Hosaka Koji , Hoh Brian L.
Published: July 2023

Background

Aneurysmal subarachnoid hemorrhage is a devastating cerebrovascular disease associated with high morbidity and mortality. Macrophage-mediated mural inflammation is a key pathogenic component contributing to aneurysm rupture.

Objective

To investigate the effect of pharmacological inhibition of the NLRP3 inflammasome on aneurysm rupture.

Methods

Cerebral aneurysms were induced in C57BL/6 mice with a combination of hypertension and an intracranial dose of elastase. Mice were treated with either 40 mg/kg of MCC950 or saline via intraperitoneal injections. Vascular tissue at the circle of Willis was harvested for analysis via immunofluorescent microscopy or qPCR.

Results

NLRP3+ cells are more common in the aneurysm tissue compared to the normal cerebral vasculature. The mRNA expression of the downstream NLRP3 pathway components caspase-1, IL-1β, and GSDMD is also increased in the aneurysm tissue compared to healthy vessels. There was no difference in the aneurysm formation rate between MCC950- and vehicle-treated mice; however, MCC950 treatment significantly reduced aneurysm rupture rate. There was no difference in systemic blood pressure between both groups. MCC950 treatment also extended the symptom-free survival of mice after aneurysm induction. Mechanistically, NLRP3 inhibition decreased the phenotype polarization of infiltrating macrophages without affecting the total number of macrophages in the vessel wall.

Conclusions

Our results indicate that the NLRP3 inflammasome contributes to aneurysm rupture and macrophage polarization within the vessel wall. The NLRP3 pathway is a promising therapeutic target for the development of therapeutics to prevent aneurysmal hemorrhagic stroke.
Knickers in a Twist: Confronting Sexual Inequality through Art and Glass
Authors: Longwill Sophie
Published: July 2023

Knickers, big, small, plain, sensual, provocative, or practical, can be an unremarkable part of everyday life or an object of feminist protest. Women’s clothing, like the experience of womanhood itself, can often have multiple contradictory narratives. In this essay, the author discusses the history of women’s underwear and its links with socio-political revolution and feminist art. Against this contextual background, she discusses the development of the body of sculptures entitled Let’s Hook Up, a series of life-size, paper-thin drawings of lingerie in pâte de verre glass. The author details the artistic processes involved in making the works as well as the conceptual development and exploration of material and meaning. She demonstrates how artwork can act as a gateway to begin conversations about challenging topics like sexual assault whilst also providing a platform for creative expression and connection.
Editorial for the Special Issue on EdTech in Higher Education: Future Perspectives on Teaching and Learning
Authors: Leoste Janika , Marjanovic Ugljesa , Andjic Branko
Published: July 2023

In today’s rapidly evolving world, educational technologies have become indispensable tools for transforming the landscape of higher education [...]
Effectiveness of Protein and Polysaccharide Biopolymers as Dust Suppressants on Mine Soils: Large-Scale Field Trials
Authors: Sieger Johannes Lukas , Lottermoser Bernd Georg , Freer Justus
Published: July 2023

Recent laboratory studies have shown that biopolymers have the potential to act as dust suppressants on barren mine soils. However, there is a lack of field trials investigating the effectiveness of biopolymer treatments under real field conditions on a large scale. This study performed field trials to examine the potential of three biopolymers—corn starch (CS), xanthan gum (XG), and fava bean protein concentrate (FBPC)—as dust suppressants. The field trials started in August 2022 with spraying of low doses of the selected biopolymers on trial areas of an overburden dump at the Inden open-cast lignite mine, Germany. The field trials were conducted over 45 days. They included repeated measurements of dust emissions from soil plots exposed to different airflows generated by an electric blower, visual inspections, and penetrometer tests. The results showed that all biopolymer treatments effectively suppressed dust emissions in the short term up to 8 days after application. Total suspended particle emissions measured on the biopolymer-treated trial plots were significantly reduced and ranged from 0.05 to 0.27 mg/m3 compared to the untreated control (4.5 to 39.2 mg/m3). The visual inspections and penetrometer tests supported these results. After day 8, rainfall-induced leaching of the biopolymers resulted in the rapid degradation of the treatments’ effectiveness. The results suggest that the treatments would have lasted longer under dry conditions. Thus, the field trials provide practical evidence that biopolymers can effectively mitigate dust emissions on exposed, undisturbed mine soils in the short term, making them a bio-based alternative to traditional dust suppressants, such as chloride salts or petroleum-based products.
The Effects of Polyaniline Nanofibers and Graphene Flakes on the Electrical Properties and Mechanical Properties of ABS-like Resin Composites Obtained by DLP 3D Printing
Authors: Jang Somi , Cho Sunghun
Published: July 2023

Three-dimensional printing is regarded as a future-oriented additive manufacturing technology that is making significant contributions to the field of polymer processing. Among the 3D printing methods, the DLP (digital light processing) technique has attracted great interest because it requires a short printing time and enables high-quality printing through selective light curing of polymeric materials. In this study, we report a fabrication method for ABS-like resin composites containing polyaniline (PANI) nanofibers and graphene flakes suitable for DLP 3D printing. As-prepared ABS-like resin composite inks employing PANI nanofibers and graphene flakes as co-fillers were successfully printed, obtaining highly conductive and mechanically robust products with the desired shapes and different sizes through DLP 3D printing. The sheet resistance of the 3D-printed composites was reduced from 2.50 × 1015 ohm/sq (sheet resistance of pristine ABS-like resin) to 1.61 × 106 ohm/sq by adding 3.0 wt.% of PANI nanofibers and 1.5 wt.% of graphene flakes. Furthermore, the AP3.0G1.5 sample (the 3D-printed composite containing 3.0 wt.% of PANI nanofibers and 1.5 wt.% of graphene flakes) exhibited 2.63 times (22.23 MPa) higher tensile strength, 1.47 times (553.8 MPa) higher Young’s modulus, and 5.07 times (25.83%) higher elongation at break values compared to the pristine ABS-like resin with a tensile strength of 8.46 MPa, a Young’s modulus of 376.6 MPa, and an elongation at break of 5.09%. Our work suggests the potential use of highly conductive and mechanically robust ABS-like resin composites in the 3D printing industry. This article not only provides optimized DLP 3D printing conditions for the ABS-like resin, which has both the advantages of the ABS resin and the advantages of a thermoplastic elastomer (TPE), but also presents the effective manufacturing process of ABS-like resin composites with significantly improved conductivity and mechanical properties.
Three-Dimensional-Printed Carbon Nanotube/Polylactic Acid Composite for Efficient Electromagnetic Interference Shielding
Authors: Xu Zhenzhen , Dou Tiantian , Wang Yazhou , Zuo Hongmei , Chen Xinyu , Zhang Mingchun , Zou Lihua
Published: July 2023

High-performance electromagnetic interference (EMI) shielding materials with ultralow density and environment-friendly properties are greatly demanded to address electromagnetic radiation pollution. Herein, carbon nanotube/polylactic acid (CNT/PLA) materials with different CNT contents, which exhibit characteristics of light weight, environmental protection and good chemical stability, are fabricated using 3D printing technology, where CNTs are evenly distributed and bind well with PLA. The performances of 3D-printed CNT/PLA composites are improved compared to pure 3D-printed PLA composites, which include mechanical properties, conductive behaviors and electromagnetic interference (EMI) shielding. The EMI shielding effectiveness (SE) of CNT/PLA composites could be improved when the content of CNTs increase. When it reaches 15 wt%, the EMI SE of 3D-printed CNT/PLA composites could get up to 47.1 dB, which shields 99.998% of electromagnetic energy. Meanwhile, the EMI shielding mechanism of 3D-printed CNT/PLA composites is mainly of absorption loss, and it generally accounts for more than 80% of the total shielding loss. These excellent comprehensive performances endow a 3D-printed CNT/PLA composite with great potential for use in industrial and aerospace areas.
Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications
Authors: Yasin Siti Nor Najihah , Said Zulfahmi , Halib Nadia , Rahman Zulaiha A , Mokhzani Noor Izzati
Published: July 2023

Excellent wound dressings should have crucial components, including high porosity, non-toxicity, high water absorption, and the ability to retain a humid environment in the wound area and facilitate wound healing. Unfortunately, current wound dressings hamper the healing process, with poor antibacterial, anti-inflammatory, and antioxidant activity, frequent dressing changes, low biodegradability, and poor mechanical properties. Hydrogels are crosslinked polymer chains with three-dimensional (3D) networks that have been applicable as wound dressings. They could retain a humid environment on the wound site, provide a protective barrier against pathogenic infections, and provide pain relief. Hydrogel can be obtained from natural, synthetic, or hybrid polymers. Honey is a natural substance that has demonstrated several therapeutic efficacies, including anti-inflammatory, antibacterial, and antioxidant activity, which makes it beneficial for wound treatment. Honey-based hydrogel wound dressings demonstrated excellent characteristics, including good biodegradability and biocompatibility, stimulated cell proliferation and reepithelization, inhibited bacterial growth, and accelerated wound healing. This review aimed to demonstrate the potential of honey-based hydrogel in wound healing applications and complement the studies accessible regarding implementing honey-based hydrogel dressing for wound healing.
Quality of Life in Multiple Sclerosis: The Predictive Roles of Positive Body Image and Meaning in Life
Authors: Barbosa Maria Carolina , Torres Sandra , Barbosa Raquel , Vieira Filipa , Lencastre Leonor , Guerra Marina Prista
Published: July 2023

Multiple sclerosis (MS) is a chronic neurological disease with a global prevalence that has risen over the past decade. The literature suggests that in comparison with a healthy control (HC) group, people with MS experience lower levels of quality of life (QoL). The purpose of this study was (1) to investigate the differences in QoL and a set of psychosocial variables between MS patients and an HC group; (2) to examine the correlations between QoL and psychosocial, sociodemographic, and clinical variables; and (3) to assess the predictive value of a set of psychosocial, sociodemographic, and clinical variables for the QoL of patients with MS. Participants in the clinical group (n = 135) and the HC group (n = 170) filled in a sociodemographic questionnaire and self-report assessments measuring QoL, body appreciation, body acceptance by others, functionality appreciation, body responsiveness, meaning in life, and difficulties in emotion regulation. The results show that the MS group had lower general, physical, psychological, and social QoL than the HC group and that body appreciation, body acceptance by others, body functionality, meaning in life, and difficulties in emotion regulation are important predictors of QoL.