bluuebunny/crossref_metadata_2025 huggingface dataset:
Friction Stir Lap Welding of Inconel 625 and a High Strength Steel
Authors: Bossle Elisangela Pelizzari , Vicharapu Buchibabu , Lemos Guilherme Vieira Braga , Lessa Cleber Rodrigo de Lima , Bergmann Luciano , dos Santos Jorge Fernandez , Clarke Thomas Gabriel Rosauro , De Amitava
Published: January 2023

The joining of dissimilar hard metals such as high-strength steel and nickel-based alloy is required for shipbuilding and offshore applications to enhance the strength, fracture toughness, and corrosion resistance of the exposed parts. However, the joining of these dissimilar alloys has remained a major challenge due to the limited solubility of Fe and Ni in each other, which commonly results in the formation of brittle intermetallic compounds. We present here a novel investigation on the joining of overlapped nickel-based alloy 625 and marine-grade GL E36 steel plates by friction stir lap welding (FSLW). The interface microstructure and its influence on joint strength are rigorously tested. The main bonding mechanism is found to be the mechanical mixing of Fe and Ni along the interface. The interface thermal cycles are computed by a three-dimensional numerical heat transfer model and their effects on the microstructure are examined. Multiple micro tensile specimens are extracted from the stir zone to examine the through-thickness variation in the stir zone properties. The welded joint is characterized further by evaluating the interface microhardness distribution, lap-shear strength, and surface residual stresses.
Features of Mycobacterium bovis Complete Genomes Belonging to 5 Different Lineages
Authors: Charles Ciriac , Conde Cyril , Vorimore Fabien , Cochard Thierry , Michelet Lorraine , Boschiroli Maria Laura , Biet Franck
Published: January 2023

Mammalian tuberculosis (TB) is a zoonotic disease mainly due to Mycobacterium bovis (M. bovis). A current challenge for its eradication is understanding its transmission within multi-host systems. Improvements in long-read sequencing technologies have made it possible to obtain complete bacterial genomes that provide a comprehensive view of species-specific genomic features. In the context of TB, new genomic references based on complete genomes genetically close to field strains are also essential to perform precise field molecular epidemiological studies. A total of 10 M. bovis strains representing each genetic lineage identified in France and in other countries were selected for performing complete assembly of their genomes. Pangenome analysis revealed a “closed” pangenome composed of 3900 core genes and only 96 accessory genes. Whole genomes-based alignment using progressive Mauve showed remarkable conservation of the genomic synteny except that the genomes have a variable number of copies of IS6110. Characteristic genomic traits of each lineage were identified through the discovery of specific indels. Altogether, these results provide new genetic features that improve the description of M. bovis lineages. The availability of new complete representative genomes of M. bovis will be useful to epidemiological studies and better understand the transmission of this clonal-evolving pathogen.
ecBSU1: A Genome-Scale Enzyme-Constrained Model of Bacillus subtilis Based on the ECMpy Workflow
Authors: Wu Ke , Mao Zhitao , Mao Yufeng , Niu Jinhui , Cai Jingyi , Yuan Qianqian , Yun Lili , Liao Xiaoping , Wang Zhiwen , Ma Hongwu
Published: January 2023

Genome-scale metabolic models (GEMs) play an important role in the phenotype prediction of microorganisms, and their accuracy can be further improved by integrating other types of biological data such as enzyme concentrations and kinetic coefficients. Enzyme-constrained models (ecModels) have been constructed for several species and were successfully applied to increase the production of commodity chemicals. However, there was still no genome-scale ecModel for the important model organism Bacillus subtilis prior to this study. Here, we integrated enzyme kinetic and proteomic data to construct the first genome-scale ecModel of B. subtilis (ecBSU1) using the ECMpy workflow. We first used ecBSU1 to simulate overflow metabolism and explore the trade-off between biomass yield and enzyme usage efficiency. Next, we simulated the growth rate on eight previously published substrates and found that the simulation results of ecBSU1 were in good agreement with the literature. Finally, we identified target genes that enhance the yield of commodity chemicals using ecBSU1, most of which were consistent with the experimental data, and some of which may be potential novel targets for metabolic engineering. This work demonstrates that the integration of enzymatic constraints is an effective method to improve the performance of GEMs. The ecModel can predict overflow metabolism more precisely and can be used for the identification of target genes to guide the rational design of microbial cell factories.
Tracking Amorphous Calcium Carbonate Crystallization Products with Far-Infrared Spectroscopy
Authors: Gao Boyang , Poduska Kristin M.
Published: January 2023

We prepared solution-precipitated amorphous calcium carbonate by two similar methods and tracked structural changes over time as they crystallized. By cross-referencing mid-range infrared (400–4000 cm−1) with far-infrared (100–400 cm−1) spectral features, and by comparing with powder X-ray diffraction data for the aged crystallized products, we provide guidelines for—and potential limitations of—using far-infrared spectroscopy to assess multi-phase Mg-containing calcium carbonate samples that include amorphous or poorly crystallized components.
New Mineral Occurrences in Massive Sulfide Deposits from Mănăilă, Eastern Carpathians, Romania
Authors: Damian Gheorghe , Apopei Andrei Ionuț , Buzatu Andrei , Maftei Andreea Elena , Damian Floarea
Published: January 2023

The massive sulfide deposits (VMS) from Mănăilă are associated with the metamorphic formations of the Tulgheș Lithogroup from the Bucovinian Nappes of the Crystalline-Mesozoic Zone in the Eastern Carpathians, Romania. The following types of ore were identified: pyrite-polymetallic, pyrite copper, compact and precompact copper, and quartz-precompact copper. The polymetallic mineralization consists of pyrite, chalcopyrite, sphalerite, galena, and subordinately arsenopyrite and tennantite. The copper, especially the quartz-copper mineralizations, have a distinct mineralogical composition compared to the other metamorphosed mineralizations of the Tulgheș Lithogroup. These types of deposits from Mănăilă contain large amounts of bornite and chalcocite along with chalcopyrite. Tennantite is abundant and has up to a 3.57 wt.% of bismuth. Wittichenite was identified for the first time in the metamorphic mineralizations and mawsonite was identified as the first occurrence in Romania. An unnamed mineral with the formula: Cu,Fe11Pb,AgS7 was also identified, belonging to the sulfides group. The compact and precompact pyrite-rich ores, located in sericite ± quartzite schists and covered by rhyolitic metatuffs, are of hydrothermal-sedimentary type metamorphosed in the greenschist facies. The source of the quartz-copper mineralization would be the retromorphic or metasomatic hydrothermal solutions that circulated through major fractures.
Efficacy and Long-Term Safety of Ibuprofen Gargle for Oral Lichen Planus: A Study Protocol of Randomized Crossover and Long-Term Extension Trials
Authors: Kitahiro Yumi , Ioroi Takeshi , Kakei Yasumasa , Yamashita Junya , Kimoto Akira , Hasegawa Takumi , Morioka Asami , Yamamoto Kazuhiro , Akashi Masaya , Yano Ikuko
Published: January 2023

Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.
p-Sulfonato-Calix[4]arene Micelles Stabilize a Povidone Iodine Solution: Supramolecular Interactions, Iodine Retention, and Bactericidal Activity
Authors: Migliore Rossella , Ferreri Loredana , Aleo Danilo , Leotta Claudia Giovanna , Pitari Giovanni Mario , D’Antona Nicola , Sgarlata Carmelo , Consoli Grazia Maria Letizia
Published: January 2023

Povidone iodine (PVPI) is an antiseptic widely used against a broad spectrum of pathogens. However, undesired side-effects are still associated with PVPI treatment due to the irritant effect of iodine. Reducing the concentration of a PVPI formulation could provide safer and more friendly formulations, for routine use and applications in very delicate organs such as the eye. However, managing the storage of a low-concentration solution of PVPI is challenging due to the high iodine volatility. In this study, we demonstrated that an amphiphilic p-sulfonato-calix[4]arene derivative forming micelles (SC4OC6) improves the stability of a 0.1% PVPI aqueous buffered solution. UV-vis and NMR spectra as well as dynamic and electrophoretic light scattering measurements showed that SC4OC6 establishes non-covalent supramolecular interactions with PVPI, resulting in the formation of nanoaggregates with a negatively charged surface. Isothermal titration calorimetry provided the aggregation parameters and evidenced that the formation of the supramolecular assembly is an enthalpically favored process. The interaction of SC4OC6 with PVPI enhances the iodine retention and stability of the solution without affecting the rapid and effective bactericidal activity of PVPI, as demonstrated by a time-killing assay with Staphylococcus epidermidis.
In Situ Grown Mesoporous Structure of Fe-Dopant@NiCoOX@NF Nanoneedles as an Efficient Supercapacitor Electrode Material
Authors: Anil Kumar Yedluri , Koyyada Ganesh , Kumar Kulurumotlakatla Dasha , Kim Jae Hong , Moniruzzaman Md , Alzahmi Salem , Obaidat Ihab M.
Published: January 2023

In this study, we designed mixed metal oxides with doping compound nano-constructions as efficient electrode materials for supercapacitors (SCs). We successfully prepared the Fe-dopant with NiCoOx grown on nickel foam (Fe-dopant@NiCoOx@NF) through a simple hydrothermal route with annealing procedures. This method provides an easy route for the preparation of high activity SCs for energy storage. Obtained results revealed that the Fe dopant has successfully assisted NiCoOx lattices. The electrochemical properties were investigated in a three-electrode configuration. As a composite electrode for SC characteristics, the Fe-dopant@NiCoOx@NF exhibits notable electrochemical performances with very high specific capacitances of 1965 F g−1 at the current density of 0.5 A g−1, and even higher at 1296 F g−1 and 30 A g−1, respectively, which indicate eminent and greater potential for SCs. Moreover, the Fe-dopant@NiCoOx@NF nanoneedle composite obtains outstanding cycling performances of 95.9% retention over 4500 long cycles. The improved SC activities of Fe-dopant@NiCoOx@NF nanoneedles might be ascribed to the synergistic reactions of the ternary mixed metals, Fe-dopant, and the ordered nanosheets grown on NF. Thus, the Fe-dopant@NiCoOx@NF nanoneedle composite with unique properties could lead to promising SC performance.
Supercurrent in Bi4Te3 Topological Material-Based Three-Terminal Junctions
Authors: Kölzer Jonas , Jalil Abdur Rehman , Rosenbach Daniel , Arndt Lisa , Mussler Gregor , Schüffelgen Peter , Grützmacher Detlev , Lüth Hans , Schäpers Thomas
Published: January 2023

In this paper, in an in situ prepared three-terminal Josephson junction based on the topological insulator Bi4Te3 and the superconductor Nb the transport properties are studied. The differential resistance maps as a function of two bias currents reveal extended areas of Josephson supercurrent, including coupling effects between adjacent superconducting electrodes. The observed dynamics for the coupling of the junctions is interpreted using a numerical simulation of a similar geometry based on a resistively and capacitively shunted Josephson junction model. The temperature dependency indicates that the device behaves similar to prior experiments with single Josephson junctions comprising topological insulators’ weak links. Irradiating radio frequencies to the junction, we find a spectrum of integer Shapiro steps and an additional fractional step, which is interpreted with a skewed current–phase relationship. In a perpendicular magnetic field, we observe Fraunhofer-like interference patterns in the switching currents.
Effect of Synthesized Titanium Dioxide Nanofibers Weight Fraction on the Tribological Characteristics of Magnesium Nanocomposites Used in Biomedical Applications
Authors: Alnaser Ibrahim A. , Abdo Hany S. , Abdo Mohamed S. , Alkalla Mohamed , Fouly Ahmed
Published: January 2023

Biomedical applications, such as artificial implants, are very significant for the disabled due to their usage in orthopedics. Nevertheless, available materials in such applications have insufficient mechanical and tribological properties. The current study investigated the mechanical and tribological properties of a biomedical metallic material, magnesium (Mg), after incorporating titanium dioxide nanofibers (TiO2) with different loading fractions. The TiO2 nanofibers were synthesized using the electrospinning technique. The ball-milling technique was utilized to ensure the homogenous distribution of TiO2 nanofibers inside the Mg matrix. Then, samples of the mixed powder with different loading fractions of TiO2 nanofibers, 0, 1, 3, 5, and 10 wt.%, were fabricated using a high-frequency induction heat sintering technique. The physicomechanical and tribological properties of the produced Mg/TiO2 nanocomposites were evaluated experimentally. Results showed an enhancement in mechanical properties and wear resistance accompanied by an increase in the weight fraction of TiO2 nanofibers up to 5%. A finite element model was built to assess the load-carrying capacity of the Mg/TiO2 composite to estimate different contact stresses during the frictional process. The finite element results showed an agreement with the experimental results.
Cyclic Buckling Characterization of an Individual MWCNT Using Quantitative In Situ TEM Axial Compression
Authors: Samira Raz , Cohen Adam , Patolsky Fernando , Lachman Noa
Published: January 2023

Carbon nanotubes (CNTs) are extremely conductive and flexible, making them ideal for applications such as flexible electronics and nanoelectromechanical systems. However, in order to properly apply them in such devices, their long-term durability must be assessed. In the present study, we demonstrate cyclic loading of a thick MWCNT (175 nm) under axial compression, observed in situ under a transmission electron microscope (TEM). The force was applied via controlled displacement, while real-time TEM videos of the deformation process were gathered to produce the morphological data. The in situ observations combined with force–displacement curves revealed the onset of buckling instabilities, and the elastic limits of the tube were assessed. The MWCNT retained its original structure even after 68 loading–unloading cycles, despite observed clues for structural distortions. The stiffness of the tube, calculated after each loading cycle, was in a 0.15 to 0.28 TPa range—comparable to the literature, which further validates the measurement set-up. These in situ tests demonstrate the resilience of CNTs to fatigue which can be correlated with the CNTs’ structure. Such correlations can help tailoring CNTs’ properties to specific applications.
Effect of the TiO2 Colloidal Size Distribution on the Degradation of Methylene Blue
Authors: Kim So-Yul , Lee Tae-Geol , Hwangbo Seon-Ae , Jeong Jong-Ryul
Published: January 2023

TiO2 is the most commonly used photocatalyst in water treatment. The particle size of TiO2 is an important factor that significantly influences its activity during photocatalytic degradation. In the presence of liquid, the properties of nanopowders composed of exactly the same product clearly differ according to their aggregation size. In this study, TiO2 nanoparticles with a controlled size were fabricated by focused ultrasound dispersion. The high energy generated by this system was used to control the size of TiO2 particles in the suspension. The constant high energy released by cavitation enabled the dispersion of the particles without a surfactant. The activities of the prepared TiO2 photocatalysts for methylene blue (MB) degradation were then compared. The dye degradation effect of the photocatalyst was as high as 61.7% after 10 min when the size of the powder was controlled in the solution, but it was only as high as 41.0% when the aggregation size was not controlled. Furthermore, when the TiO2 concentration exceeded a certain level, the photocatalytic activity of TiO2 decreased. Controlling the size of the aggregated photocatalyst particles is, therefore, essential in water-treatment technologies utilizing TiO2 photocatalytic properties, and adjusting the TiO2 concentration is an important economic factor in this photocatalytic technology. This study contributes to the development of processes for degrading dyes, such as MB, released from wastewater into aquatic environments.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
Authors: Bedenić Branka , Bratić Vesna , Mihaljević Slobodan , Lukić Anita , Vidović Karlo , Reiner Krešimir , Schöenthaler Silvia , Barišić Ivan , Zarfel Gernot , Grisold Andrea
Published: January 2023

During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious forms of COVID-19. In total, 118 patients were hospitalized in the intensive care unit (ICU) of the COVID-19 hospital. Forty-six out of 118 patients (39%) developed serious bacterial infection (VAP or BSI or both) during their stay in ICU. The total mortality rate was 83/118 (70%). The mortality rate due to bacterial infection or a combination of ARDS with bacterial superinfection was 33% (40/118). Six patients had MDR organisms and 34 had XDR (extensively drug-resistant). The dominant species was Acinetobacter baumannii with all isolates (34) being carbapenem-resistant (CRAB) and positive for carbapenem-hydrolyzing oxacillinases (CHDL). One Escherichia coli causing pneumonia harboured the blaCTX-M-15 gene. It appears that the dominant resistance determinants of causative agents depend on the local epidemiology in the particular COVID center. Acinetobacter baumannii seems to easily spread in overcrowded ICUs. Croatia belongs to the 15 countries in the world with the highest mortality rate among COVID-19 patients, which could be in part attributable to the high prevalence of bacterial infections in local ICUs.
Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges
Authors: Nicholson Thomas A. , Sagmeister Michael , Wijesinghe Susanne N. , Farah Hussein , Hardy Rowan S. , Jones Simon W.
Published: January 2023

Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. Collectively, these conditions involve multiple tissues, including skeletal muscle, bone, articular cartilage and the synovium within the joint lining. In this review, we discuss the potential for oligonucleotide therapies to combat the unmet clinical need in musculoskeletal disorders by evaluating the successes of oligonucleotides to modify candidate pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system. Further, we discuss the challenges that remain for the clinical development of oligonucleotides therapies for musculoskeletal disorders and evaluate some of the current approaches to overcome these.
Investigations on Five PMMA Closed Types of Piezo Actuators as a Cooling Fan
Authors: Wang Rong-Tsu , Wang Jung-Chang
Published: January 2023

There are five closed types of piezo actuators (closed type of PA, closed PA) as a cooling fan relative to those different PAJs of the previous work (open type of PAJ, open PAJ) for analysis in the present study. Closed PA was composed of circular piezoelectric ceramics (PCs) and acrylic (PMMA) plates and investigated on five different types at operating conditions. The results show that the noise of the closed PA is quieter than that of the open PAJ by about 10 dB. When the closed PA is deposed at a suitable distance of 10 to 20 mm from the heat source, averting sucking back the high-temperature fluids around that, the thermal convection coefficient is above 120% more than that of the conventional rotary fan. The cooling performances of these five closed PAs were evaluated by thermal analysis technique, and the convection thermal resistance of the best closed PA can be decreased by over 15%. In terms of energy consumption, a monolithic closed PA was less than 10% than that of a rotary fan. Among these five closed PAs, the best one has the essential qualities that the diameter of the piezoelectric sheet is 41 mm, the opening length is 4 mm, and the outer opening length is 10 mm. Moreover, the best operating conditions are a voltage frequency of 300 Hz and a release distance of 15 mm in the present study.
Performance of Concentrically Loaded RC Wall-like Columns Upgraded with Innovative Hybrid NSM/CFRP System
Authors: Elsanadedy Hussein , Abbas Husain , Almusallam Tarek , Al-Salloum Yousef
Published: January 2023

In RC (reinforced concrete) frame structures, wall-like columns are laid within the space occupied by masonry walls to maximize usable space and thus minimize the column projections into the usable area. These columns often require strengthening owing to various reasons, including increasing the number of stories, changes in building usage, and others. The use of a hybrid system comprising NSM (near-surface mounted) steel rebars combined with CFRP (carbon-fiber reinforced polymer) laminates may be considered a sound technique for strengthening such wall-like building columns. The prime aim of this study is to devise an efficient scheme using a hybrid NSM/CFRP system to strengthen existing RC wall-like columns. Six half-scale RC wall-like columns were prepared and tested under monotonic concentric axial compression. Two columns were unstrengthened to serve as control specimens (CW1 and CW2), and four specimens were strengthened using four different schemes (SW1, SW2, SW3, and SW4). As favored by architects, all strengthening schemes were designed so that the dimensions of the column cross-section were not increased. The effects of strengthening schemes on the enhancement of axial capacity, energy dissipated, and stiffness were evaluated to find the most efficient scheme. Among the four studied schemes, using vertical continuous NSM rebars in combination with the wrapping of the three CFRP layers onto the exterior column surface (in specimen SW2) was the most efficient as it enhanced the ultimate load capacity by 80%. Three-dimensional FE (finite element) analysis was also conducted to predict the response of test specimens. The test results matched well with the FE outputs, which justified the accuracy of the used constitutive models for concrete, steel rebars, and CFRP sheets.
Preparation, Structure, and Properties of PVA–AgNPs Nanocomposites
Authors: Velgosova Oksana , Mačák Lívia , Múdra Erika , Vojtko Marek , Lisnichuk Maksym
Published: January 2023

The aim of the work was to prepare a polymer matrix composite doped by silver nanoparticles and analyze the influence of silver nanoparticles (AgNPs) on polymers’ optical and toxic properties. Two different colloids of AgNPs were prepared by chemical reduction. The first colloid, a blue one, contains stable triangular nanoparticles (the mean size of the nanoparticles was ~75 nm). UV–vis spectrophotometry showed that the second colloid, a yellow colloid, was very unstable. Originally formed spherical particles (~11 nm in diameter) after 25 days changed into a mix of differently shaped nanoparticles (irregular, triangular, rod-like, spherical, decahedrons, etc.), and the dichroic effect was observed. Pre-prepared AgNPs were added into the PVA (poly(vinyl alcohol)) polymer matrix and PVA–AgNPs composites (poly(vinyl alcohol) doped by Ag nanoparticles) were prepared. PVA–AgNPs thin layers (by a spin-coating technique) and fibers (by electrospinning and dip-coating techniques) were prepared. TEM and SEM techniques were used to analyze the prepared composites. It was found that the addition of AgNPs caused a change in the optical and antibiofilm properties of the non-toxic and colorless polymer. The PVA–AgNPs composites not only showed a change in color but a dichroic effect was also observed on the thin layer, and a good antibiofilm effect was also observed.
Experimental Production of Iron-Bearing Sinters Using Chars from Waste Car Tires
Authors: Niesler Marian , Stecko Janusz , Gierad Damian , Nowak Martyna , Stelmach Sławomir
Published: January 2023

The metallurgical industry is seeking raw material substitutes more and more intensively in order to replace materials traditionally used in pig iron production. Research has been conducted on the use of char obtained from waste car tires via a pyrolysis process in an iron ore sintering process. The char obtained from car tires could be a potential substitute for some of the coke breeze used in the iron ore sintering process. However, the Zn and S content of the char is a major technological issue. This paper presents the results of research conducted to assess the possibility of substituting coke breeze with a commercial char from waste tires. The experiments were carried out in a laboratory stand capable of sintering 200 kg of sintering blend. The results obtained show that it is possible to replace 10 %m/m of coke breeze with waste tire char without any technological danger for sintering lines. The application of waste tire char in metallurgical processes is an example of actions that form part of the circular economy and also of the appropriate use of anthropogenic resources that are technologically available.
Introducing the Effective Features Using the Particle Swarm Optimization Algorithm to Increase Accuracy in Determining the Volume Percentages of Three-Phase Flows
Authors: Chen Tzu-Chia , Alizadeh Seyed Mehdi , Albahar Marwan Ali , Thanoon Mohammed , Alammari Abdullah , Guerrero John William Grimaldo , Nazemi Ehsan , Eftekhari-Zadeh Ehsan
Published: January 2023

What is presented in this research is an intelligent system for detecting the volume percentage of three-phase fluids passing through oil pipes. The structure of the detection system consists of an X-ray tube, a Pyrex galss pipe, and two sodium iodide detectors. A three-phase fluid of water, gas, and oil has been simulated inside the pipe in two flow regimes, annular and stratified. Different volume percentages from 10 to 80% are considered for each phase. After producing and emitting X-rays from the source and passing through the pipe containing a three-phase fluid, the intensity of photons is recorded by two detectors. The simulation is introduced by a Monte Carlo N-Particle (MCNP) code. After the implementation of all flow regimes in different volume percentages, the signals recorded by the detectors were recorded and labeled. Three frequency characteristics and five wavelet transform characteristics were extracted from the received signals of each detector, which were collected in a total of 16 characteristics from each test. The feature selection system based on the particle swarm optimization (PSO) algorithm was applied to determine the best combination of extracted features. The result was the introduction of seven features as the best features to determine volume percentages. The introduced characteristics were considered as the input of a Multilayer Perceptron (MLP) neural network, whose structure had seven input neurons (selected characteristics) and two output neurons (volume percentage of gas and water). The highest error obtained in determining volume percentages was equal to 0.13 as MSE, a low error compared with previous works. Using the PSO algorithm to select the most optimal features, the current research’s accuracy in determining volume percentages has significantly increased.
Advancements in Oncoproteomics Technologies: Treading toward Translation into Clinical Practice
Authors: Punetha Ankita , Kotiya Deepak
Published: January 2023

Proteomics continues to forge significant strides in the discovery of essential biological processes, uncovering valuable information on the identity, global protein abundance, protein modifications, proteoform levels, and signal transduction pathways. Cancer is a complicated and heterogeneous disease, and the onset and progression involve multiple dysregulated proteoforms and their downstream signaling pathways. These are modulated by various factors such as molecular, genetic, tissue, cellular, ethnic/racial, socioeconomic status, environmental, and demographic differences that vary with time. The knowledge of cancer has improved the treatment and clinical management; however, the survival rates have not increased significantly, and cancer remains a major cause of mortality. Oncoproteomics studies help to develop and validate proteomics technologies for routine application in clinical laboratories for (1) diagnostic and prognostic categorization of cancer, (2) real-time monitoring of treatment, (3) assessing drug efficacy and toxicity, (4) therapeutic modulations based on the changes with prognosis and drug resistance, and (5) personalized medication. Investigation of tumor-specific proteomic profiles in conjunction with healthy controls provides crucial information in mechanistic studies on tumorigenesis, metastasis, and drug resistance. This review provides an overview of proteomics technologies that assist the discovery of novel drug targets, biomarkers for early detection, surveillance, prognosis, drug monitoring, and tailoring therapy to the cancer patient. The information gained from such technologies has drastically improved cancer research. We further provide exemplars from recent oncoproteomics applications in the discovery of biomarkers in various cancers, drug discovery, and clinical treatment. Overall, the future of oncoproteomics holds enormous potential for translating technologies from the bench to the bedside.
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles
Authors: Heck Kathleen A. , Lindholm Håvard T. , Niederdorfer Barbara , Tsirvouli Eirini , Kuiper Martin , Flobak Åsmund , Lægreid Astrid , Thommesen Liv
Published: January 2023

Colorectal cancer (CRC) is one of the most prevalent cancers, driven by several factors including deregulations in intracellular signalling pathways. Small extracellular vesicles (sEVs) are nanosized protein-packaged particles released from cells, which are present in liquid biopsies. Here, we characterised the proteome landscape of sEVs and their cells of origin in three CRC cell lines HCT116, HT29 and SW620 to explore molecular traits that could be exploited as cancer biomarker candidates and how intracellular signalling can be assessed by sEV analysis instead of directly obtaining the cell of origin itself. Our findings revealed that sEV cargo clearly reflects its cell of origin with proteins of the PI3K-AKT pathway highly represented in sEVs. Proteins known to be involved in CRC were detected in both cells and sEVs including KRAS, ARAF, mTOR, PDPK1 and MAPK1, while TGFB1 and TGFBR2, known to be key players in epithelial cancer carcinogenesis, were found to be enriched in sEVs. Furthermore, the phosphopeptide-enriched profiling of cell lysates demonstrated a distinct pattern between cell lines and highlighted potential phosphoproteomic targets to be investigated in sEVs. The total proteomic and phosphoproteomics profiles described in the current work can serve as a source to identify candidates for cancer biomarkers that can potentially be assessed from liquid biopsies.
The Use of Religious Signs in Schools in Germany, France, England and Spain: The Islamic Veil
Authors: Llorent-Bedmar Vicente , Torres-Zaragoza Lucía , Sánchez-Lissen Encarnación
Published: January 2023

The use of religious signs in schools, as in other areas of the public sphere, is a current topic, given that legislative changes are constantly taking place. In countries as close as Germany, France, England and Spain, the legislation governing the wearing of the Islamic veil differs considerably due to their different historical, cultural, social, economic and idiosyncratic contexts. Leaving aside the ethnocentric perspective, in this paper a comparative study of the situation was carried out in these four countries. The main results include a negative attitude towards the wearing of the Islamic veil in France as opposed to a more tolerant position in England and Spain. In the case of Germany, there is a greater diversity of positions due to the characteristic autonomy of each federal state. Given the different types of veils, the reasons for wearing them, the traditions of each society and regional idiosyncrasies, it is considered that, a priori, there should not be a fight against its use, although it is recommended to adopt a belligerent stance against its imposition.
The Phenomenology of Prayer and the Relationship between Phenomenology and Theology
Authors: Turcan Nicolae
Published: January 2023

The present article analyzes the relationship between phenomenology and theology, starting from some examples of the phenomenology of prayer. First, the article presents the phenomenology of prayer in the writings of phenomenologists such as Jean-Luc Marion, Jean-Yves Lacoste, Christina Gschwandtner and Natalie Depraz, indicating that the type of phenomenology and its relationship with theology influence the way in which they approach the theme of prayer. Second, the paper proposes a systematization of prayer, starting from the personal pronouns uttered when praying: I, you (thou) and he. “I” sees oneself as being called by God to a transfiguration which is impossible through one’s own powers and visible in the experience of the plenitude and joy of prayer; “You” provides the predicative dimension of the discourse and reveals communion either with God or, in the case of liturgy, with others; “He”, used less frequently in prayer, can constitute a source for a later theoretical discourse, being recognized as a “mysterious presence”. Following these analyses, the article concludes that there are two major relationships between phenomenology and theology: that of partial overlap, called theo-phenomenology, and that of rigorous delimitation. Regardless of the preferred model, the use of phenomenology for theology proves to be fruitful.
Gender Medicine: A New Possible Frontiers of Venous Thromboembolism
Authors: Ciarambino Tiziana , Crispino Pietro , Para Ombretta , Giordano Mauro
Published: January 2023

From the data in our possession derived from the literature, it has been shown that men have a high risk and appear to have a specific higher risk of suffering from thromboembolism than women, regardless of age group. Furthermore, at present, this difference between the two sexes has not yet been justified by scientific evidence. Taking this evidence into account, this review was designed to find information in the literature that could be potentially useful and that is crucial to knowledge about the differences between men and women in the genesis of thromboembolic disease. The role of the constitutional and physical factors underlying the difference between the two sexes, the different habitual lifestyles, the role of sex hormones, and what happens in situations such as venous thromboembolism in the course of a neoplastic disease or in the case of pregnancy. We have also focused our efforts on correlating the gender differences between men and women in thromboembolic disease with the dysregulation of the metabolism and the activation of the inflammatory response that often underlies this pathology.
Morphological Description and Molecular Analysis of Newly Recorded Asteroid, Henricia djakonovi Chichvarkhin, 2017 (Asteroidea: Spinulosida: Echinasteridae), from Dokdo Island, Korea
Authors: Ubagan Michael Dadole , Alboasud Mariya Shihab Ahmed , Lee Taekjun
Published: January 2023

We recently collected the samples of Henricia from adjacent waters of Dokdo Island, Korea, using trimix SCUBA diving. Based on a combined result of morphological and molecular analysis, we identified our specimen as Henricia djakonovi Chichvarkhin, 2017, which is newly recorded in Korea. Morphologically, H. djakonovi has crescent abactinal plates bearing numerous pillar-shaped abactinal spines with a droplet-like apical tip. Moreover, molecular analysis based on the mitochondrial COI gene occurred that clearly distinguished H. djakonovi from other species of Henricia in the pairwise genetic distance and maximum likelihood analysis. Accordingly, 15 species of Henricia are recorded in Korean fauna, including H. djakonovi.
Quiescent Optical Solitons with Quadratic-Cubic and Generalized Quadratic-Cubic Nonlinearities
Authors: Arnous Ahmed H. , Biswas Anjan , Yıldırım Yakup , Moraru Luminita , Moldovanu Simona , Iticescu Catalina , Khan Salam , Alshehri Hashim M.
Published: January 2023

This paper studies the formulation of dark and singular stationary optical solitons that stem from quadratic-cubic and generalized quadratic-cubic forms of nonlinear refractive index coupled with nonlinear chromatic dispersion. The temporal evolution is taken to be of both kinds, namely linear and generalized. The enhanced Kudryashov’s approach enables this retrieval possible.
Multilesion Segmentations in Patients with Intracerebral Hemorrhage: Reliability of ICH, IVH and PHE Masks
Authors: Vogt Estelle , Vu Ly Huong , Cao Haoyin , Speth Anna , Desser Dmitriy , Schlunk Frieder , Dell’Orco Andrea , Nawabi Jawed
Published: January 2023

Background and Purpose: Fully automated methods for segmentation and volume quantification of intraparenchymal hemorrhage (ICH), intraventricular hemorrhage extension (IVH), and perihematomal edema (PHE) are gaining increasing interest. Yet, reliabilities demonstrate considerable variances amongst each other. Our aim was therefore to evaluate both the intra- and interrater reliability of ICH, IVH and PHE on ground-truth segmentation masks. Methods: Patients with primary spontaneous ICH were retrospectively included from a German tertiary stroke center (Charité Berlin; January 2016–June 2020). Baseline and follow-up non-contrast Computed Tomography (NCCT) scans were analyzed for ICH, IVH, and PHE volume quantification by two radiology residents. Raters were blinded to all demographic and outcome data. Inter- and intrarater agreements were determined by calculating the Intraclass Correlation Coefficient (ICC) for a randomly selected set of patients with ICH, IVH, and PHE. Results: 100 out of 670 patients were included in the analysis. Interrater agreements ranged from an ICC of 0.998 for ICH (95% CI [0.993; 0.997]), to an ICC of 0.979 for IVH (95% CI [0.984; 0.993]), and an ICC of 0.886 for PHE (95% CI [0.760; 0.938]), all p-values < 0.001. Intrarater agreements ranged from an ICC of 0.997 for ICH (95% CI [0.996; 0.998]), to an ICC of 0.995 for IVH (95% CI [0.992; 0.996]), and an ICC of 0.980 for PHE (95% CI [0.971; 0.987]), all p-values < 0.001. Conclusion Manual segmentations of ICH, IVH, and PHE demonstrate good-to-excellent inter- and intrarater reliabilities, with the highest agreement for ICH and IVH and lowest for PHE. Therefore, the degree of variances reported in fully automated quantification methods might be related amongst others to variances in ground-truth masks.
The Relationship between the Contouring Time of the Metal Artifacts Area and Metal Artifacts in Head and Neck Radiotherapy
Authors: Katsura Kouji , Tanabe Satoshi , Nakano Hisashi , Sakai Madoka , Ohta Atsushi , Kaidu Motoki , Soga Marie , Kobayashi Taichi , Takamura Masaki , Hayashi Takafumi
Published: January 2023

(1) Background: The impacts of metal artifacts (MAs) on the contouring workload for head and neck radiotherapy have not yet been clarified. Therefore, this study evaluated the relationship between the contouring time of the MAs area and MAs on head and neck radiotherapy treatment planning. (2) Methods: We used treatment planning computed tomography (CT) images for head and neck radiotherapy. MAs were classified into three severities by the percentage of CT images containing MAs: mild (<25%), moderate (25–75%), and severe (>75%). We randomly selected nine patients to evaluate the relationship between MAs and the contouring time of the MAs area. (3) Results: The contouring time of MAs showed moderate positive correlations with the MAs volume and the number of CT images containing MAs. Interobserver reliability of the extracted MAs volume and contouring time were excellent and poor, respectively. (4) Conclusions: Our study suggests that the contouring time of MAs areas is related to individual commitment rather than clinical experience. Therefore, the development of software combining metal artifact reduction methods with automatic contouring methods is necessary to reducing interobserver variability and contouring workload.
Fine Particulate Matter (PM2.5) Sources and Its Individual Contribution Estimation Using a Positive Matrix Factorization Model
Authors: Lee Gahye , KIM Minkyeong , Park Duckshin , Yoo Changkyoo
Published: January 2023

The effective management and regulation of fine particulate matter (PM2.5) is essential in the Republic of Korea, where PM2.5 concentrations are very high. To do this, however, it is necessary to identify sources of PM2.5 pollution and determine the contribution of each source using an acceptance model that includes variability in the chemical composition and physicochemical properties of PM2.5, which change according to its spatiotemporal characteristics. In this study, PM2.5 was measured using PMS-104 instruments at two monitoring stations in Bucheon City, Gyeonggi Province, from 22 April to 3 July 2020; the PM2.5 chemical composition was also analyzed. Sources of PM2.5 pollution were then identified and the quantitative contribution of each source to the pollutant mix was estimated using a positive matrix factorization (PMF) model. From the PMF analysis, secondary aerosols, coal-fired boilers, metal-processing facilities, motor vehicle exhaust, oil combustion residues, and soil-derived pollutants had average contribution rates of 5.73 μg/m3, 3.11 μg/m3, 2.14 μg/m3, 1.94 μg/m3, 1.87 μg/m3, and 1.47 μg/m3, respectively. The coefficient of determination (R2) was 0.87, indicating the reliability of the PMF model. Conditional probability function plots showed that most of the air pollutants came from areas where PM2.5-emitting facilities are concentrated and highways are present. Pollution sources with high contribution rates should be actively regulated and their management prioritized. Additionally, because automobiles are the leading source of artificially-derived PM2.5, their effective control and management is necessary.
Isotropic Perfect Fluids in Modified Gravity
Authors: Naicker Shavani , Maharaj Sunil D. , Brassel Byron P.
Published: January 2023

We generate the Einstein–Gauss–Bonnet field equations in higher dimensions for a spherically symmetric static spacetime. The matter distribution is a neutral fluid with isotropic pressure. The condition of isotropic pressure, an Abel differential equation of the second kind, is transformed to a first order nonlinear canonical differential equation. This provides a mechanism to generate exact solutions systematically in higher dimensions. Our solution generating algorithm is a different approach from those considered earlier. We show that a specific choice of one potential leads to a new solution for the second potential for all spacetime dimensions. Several other families of exact solutions to the condition of pressure isotropy are found for all spacetime dimensions. Earlier results are regained from our treatments. The difference with general relativity is highlighted in our study.
Fault Alarms and Power Performance in Hybrid Electric Vehicles Based on Hydraulic Technology
Authors: You Zhuan
Published: January 2023

In order to improve the fault alarm effect on the power performance of hydraulic hybrid electric vehicles (HEV), this paper proposes a fault alarm method for hybrid electric vehicle power performance based on hydraulic technology, builds a hybrid electric vehicle power system model, uses hydraulic technology to extract the characteristic signals of key components, uses support vector mechanisms to build a hybrid electric vehicle classifier, and obtains the fault alarm results for dynamic performance based on hydraulic technology. The results show that the proposed method can improve real-time diagnosis and alarm for engine faults in HEV, and the fault can be diagnosed after 5 s of injection, thus ensuring the dynamic stability of HEV.
The role of natioanal (level) development banks in enhancing the competitiveness and resilience of micro, small and medium-sized enterprises
Authors: Baracsi Mária
Published: January 2023

The Visegrad Four countries (‘V4 countries’) have a lot in common regarding crisis management, based on the measures introduced to manage the 2008/2009 crisis. This paper aims to introduce how the economic crisis caused by the global pandemic of coronavirus disease 2019 (‘COVID-19 pandemic’) affected the performance and position of the national development banks of the V4 countries within their financial ecosystems with particular attention to the banking operation of the Hungarian Development Bank (MFB).
The use of chelating sorbents for the effective extraction of heavy metals from alcoholic beverages in order to ensure their quality and safety
Authors:   Department of Chemistry and Ecotoxicology, Russian Biotechnological University, Moscow, Roeva N.N. , Koltsova E.G. ,   Department of Chemistry and Ecotoxicology, Russian Biotechnological University, Moscow, Zaitseva I.A. ,   Department of Chemistry and Ecotoxicology, Russian Biotechnological University, Moscow
Published: January 2023

The article describes a combined method for the determination of lead, copper and cadmium in alcoholic beverages, based on the preliminary extraction of these elements using the chelating sorbent POLYRGSA-VII-M and their subsequent determination by the absorption method with flameless atomization. Optimal sorption conditions have been developed. Concentration levels of lead, copper and cadmium in alcoholic beverages were determined. It is established that the content of these elements in the studied beverages does not exceed their maximum permissible concentrations.