bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations
Authors: Trendowski Matthew R. , Lusk Christine M. , Wenzlaff Angela S. , Neslund-Dudas Christine , Gadgeel Shirish M. , Soubani Ayman O. , Schwartz Ann G.
Published: August 2023

Background:

Polygenic risk scores (PRS) have become an increasingly popular approach to evaluate cancer susceptibility, but have not adequately represented Black populations in model development.

Methods:

We used a previously published lung cancer PRS on the basis of 80 SNPs associated with lung cancer risk in the OncoArray cohort and validated in UK Biobank. The PRS was evaluated for association with lung cancer risk adjusting for age, sex, total pack-years, family history of lung cancer, history of chronic obstructive pulmonary disease, and the top five principal components for genetic ancestry.

Results:

Among the 80 PRS SNPs included in the score, 14 were significantly associated with lung cancer risk (P < 0.05) in INHALE White participants, while there were no significant SNPs among INHALE Black participants. After adjusting for covariates, the PRS was significantly associated with risk in Whites (continuous score P = 0.007), but not in Blacks (continuous score P = 0.88). The PRS remained a statistically significant predictor of lung cancer risk in Whites ineligible for lung cancer screening under current U.S. Preventive Services Task Force guidelines (P = 0.02).

Conclusions:

Using a previously validated PRS, we did find some predictive ability for lung cancer in INHALE White participants beyond traditional risk factors. However, this effect was not observed in Black participants, indicating the need to develop and validate ancestry-specific lung cancer risk models.

Impact:

While a previously published lung cancer PRS was able to stratify White participants into different levels of risk, the model was not predictive in Blacks. Our findings highlight the need to develop and validate ancestry-specific lung cancer risk models.
Supplementary Table S1 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Authors: Tovey Holly , Sipos Orsolya , Parker Joel S. , Hoadley Katherine A. , Quist Jelmar , Kernaghan Sarah , Kilburn Lucy , Salgado Roberto , Loi Sherene , Kennedy Richard D. , Roxanis Ioannis , Gazinska Patrycja , Pinder Sarah E. , Bliss Judith , Perou Charles M. , Haider Syed , Grigoriadis Anita , Tutt Andrew , Cheang Maggie Chon U
Published: August 2023

Supplementary table 1 - Biomarkers of interest
Supplementary Figure S2 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Authors: Tovey Holly , Sipos Orsolya , Parker Joel S. , Hoadley Katherine A. , Quist Jelmar , Kernaghan Sarah , Kilburn Lucy , Salgado Roberto , Loi Sherene , Kennedy Richard D. , Roxanis Ioannis , Gazinska Patrycja , Pinder Sarah E. , Bliss Judith , Perou Charles M. , Haider Syed , Grigoriadis Anita , Tutt Andrew , Cheang Maggie Chon U
Published: August 2023

Changes in A. CIN70, B. RPS and C. PARPi7 from treatment naïve primary tumours to post-treatment metastatic samples in an independent dataset.
Multiple metastatic samples are included for some patients.
𝛃 coefficients and p-values presented for timepoint term from linear regression models with a random effect for patient to account for multiple samples from patients.
Protein Advanced Glycation End Products and Their Implications in Pancreatic Cancer
Authors: Senavirathna Lakmini , Pan Sheng , Chen Ru
Published: August 2023

Protein advanced glycation end products (AGE) formed by nonenzymatic glycation can disrupt the normal structure and function of proteins, and stimulate the receptor for AGEs (RAGE), triggering intricate mechanisms that are etiologically related to various chronic diseases, including pancreatic cancer. Many common risk factors of pancreatic cancer are the major sources for the formation of protein AGEs and glycative stress in the human body. Abnormal accumulation of protein AGEs can impair the cellular proteome and promote AGE–RAGE driven pro-inflammatory signaling cascades, leading to increased oxidative stress, protease resistance, protein dysregulation, transcription activity of STAT, NF-κB, and AP-1, aberrant status in ubiquitin-proteasome system and autophagy, as well as other molecular events that are susceptible for the carcinogenic transformation towards the development of neoplasms. Here, we review studies to highlight our understanding in the orchestrated molecular events in bridging the impaired proteome, dysregulated functional networks, and cancer hallmarks initiated upon protein AGE formation and accumulation in pancreatic cancer.
Supplementary Table 3 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
Authors: Facchinetti Francesco , Hollebecque Antoine , Braye Floriane , Vasseur Damien , Pradat Yoann , Bahleda Rastislav , Pobel Cédric , Bigot Ludovic , Déas Olivier , Florez Arango Juan David , Guaitoli Giorgia , Mizuta Hayato , Combarel David , Tselikas Lambros , Michiels Stefan , Nikolaev Sergey I. , Scoazec Jean-Yves , Ponce-Aix Santiago , Besse Benjamin , Olaussen Ken A. , Loriot Yohann , Friboulet Luc
Published: August 2023

IC50 values of Ba/F3 cells harboring FGFR3:TACC3 mutants exposed to eight selective FGFR inhibitors.
Supplementary Table 1 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
Authors: Facchinetti Francesco , Hollebecque Antoine , Braye Floriane , Vasseur Damien , Pradat Yoann , Bahleda Rastislav , Pobel Cédric , Bigot Ludovic , Déas Olivier , Florez Arango Juan David , Guaitoli Giorgia , Mizuta Hayato , Combarel David , Tselikas Lambros , Michiels Stefan , Nikolaev Sergey I. , Scoazec Jean-Yves , Ponce-Aix Santiago , Besse Benjamin , Olaussen Ken A. , Loriot Yohann , Friboulet Luc
Published: August 2023

Patient population, treatment outcomes and post-progression sample availability.
Supplementary Figure 1 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
Authors: Facchinetti Francesco , Hollebecque Antoine , Braye Floriane , Vasseur Damien , Pradat Yoann , Bahleda Rastislav , Pobel Cédric , Bigot Ludovic , Déas Olivier , Florez Arango Juan David , Guaitoli Giorgia , Mizuta Hayato , Combarel David , Tselikas Lambros , Michiels Stefan , Nikolaev Sergey I. , Scoazec Jean-Yves , Ponce-Aix Santiago , Besse Benjamin , Olaussen Ken A. , Loriot Yohann , Friboulet Luc
Published: August 2023

RNAseq analysis from tissue biopsies of 39 advanced urothelial cancers.
Table S6 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Characteristics of human subjects used in this study.
Table S2 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Genes driving the clustering of cells in UMAP #1; genes with power ≥ 0.4 are given.
Figure S9 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Gating strategy for detection of myeloid cell populations by flow cytometry.
Figure S8 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

IFN-γ but not IL-4 is associated with metaplastic pit cell expansion.
Figure S7 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Metaplastic pit cells expand within six weeks and are partially dependent on the Hp cag type IV secretion system.
Figure S14 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Figure S14. Metaplastic pit cells can be seen in gastric cancer samples.
Figure S1 from Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation
Authors: O'Brien Valerie Phoebe , Kang Yuqi , Shenoy Meera K , Finak Greg , Young William C , Dubrulle Julien , Koch Lisa , Rodriguez Martinez Armando E , Williams Jeffery , Donato Elizabeth , Batra Surinder K. , Yeung Cecilia C.S. , Grady William M , Koch Meghan A , Gottardo Raphael , Salama Nina R.
Published: August 2023

Summary of cell clusters detected in different mouse treatment groups at six and 12 weeks.
TABLE 1 from Cancer Epidemiology in the Northeastern United States (2013–2017)
Authors: Rees Judy R. , Weiss Julie E. , Gunn Christine M. , Carlos Heather A. , Dragnev Nathalie C. , Supattapone Emma Y. , Tosteson Anna N.A. , Kraft Sally A. , Vahdat Linda T. , Peacock Janet L.
Published: August 2023

Age-adjusted incidence of late-stage cancersa,b, all Races, for ME, NH, VT, and the United States, 2013–17
Supplementary Table S5 from Cancer Epidemiology in the Northeastern United States (2013–2017)
Authors: Rees Judy R. , Weiss Julie E. , Gunn Christine M. , Carlos Heather A. , Dragnev Nathalie C. , Supattapone Emma Y. , Tosteson Anna N.A. , Kraft Sally A. , Vahdat Linda T. , Peacock Janet L.
Published: August 2023

Comparison of Age-standardized Cancer Mortality*, All Races, for Maine, New Hampshire, Vermont with the United States, 2013–2017
Supplementary Figure 1 from Cancer Epidemiology in the Northeastern United States (2013–2017)
Authors: Rees Judy R. , Weiss Julie E. , Gunn Christine M. , Carlos Heather A. , Dragnev Nathalie C. , Supattapone Emma Y. , Tosteson Anna N.A. , Kraft Sally A. , Vahdat Linda T. , Peacock Janet L.
Published: August 2023

United States Regions used in the analyses; Age-adjusted Cancer Incidence in the United States, 2015-2019, all races combined; Age-adjusted Cancer Mortality in the United States, 2015-2019, all races combined
FIGURE 2 from Cancer Epidemiology in the Northeastern United States (2013–2017)
Authors: Rees Judy R. , Weiss Julie E. , Gunn Christine M. , Carlos Heather A. , Dragnev Nathalie C. , Supattapone Emma Y. , Tosteson Anna N.A. , Kraft Sally A. , Vahdat Linda T. , Peacock Janet L.
Published: August 2023

Ratios of age-standardized* cancer incidence rates (RR) and 99% CIs† for ME, NH, VT, and U.S. regions compared with United States, by race/ethnicity 2013–2017.
Automated Real-World Video Analysis of Sit-to-Stand Transitions Predicts Parkinson’s Disease Severity
Authors: Morgan Catherine , Masullo Alessandro , Mirmehdi Majid , Isotalus Hanna Kristiina , Jovan Ferdian , McConville Ryan , Tonkin Emma L. , Whone Alan , Craddock Ian
Published: August 2023

Introduction: Technology holds the potential to track disease progression and response to neuroprotective therapies in Parkinson’s disease (PD). The sit-to-stand (STS) transition is a frequently occurring event which is important to people with PD. The aim of this study was to demonstrate an automatic approach to quantify STS duration and speed using a real-world free-living dataset and look at clinical correlations of the outcomes, including whether STS parameters change when someone withholds PD medications. Methods: Eighty-five hours of video data were collected from 24 participants staying in pairs for 5-day periods in a naturalistic setting. Skeleton joints were extracted from the video data; the head trajectory was estimated and used to estimate the STS parameters of duration and speed. Results: 3.14 STS transitions were seen per hour per person on average. Significant correlations were seen between automatic and manual STS duration (Pearson rho − 0.419, p = 0.042) and between automatic STS speed and manual STS duration (Pearson rho − 0.780, p < 0.001). Significant and strong correlations were seen between the gold-standard clinical rating scale scores and both STS duration and STS speed; these correlations were not seen in the STS transitions when the participants were carrying something in their hand(s). Significant differences were seen at the cohort level between control and PD participants’ ON medications’ STS duration (U = 6,263, p = 0.018) and speed (U = 9,965, p < 0.001). At an individual level, only two participants with PD became significantly slower to STS when they were OFF medications; withholding medications did not significantly change STS duration at an individual level in any participant. Conclusion: We demonstrate a novel approach to automatically quantify and ecologically validate two STS parameters which correlate with gold-standard clinical tools measuring disease severity in PD.
Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury
Authors: Landau Daniel , Shukri Nehoray , Arazi Eden , Tobar Ana , Segev Yael
Published: August 2023

Introduction: Low-grade inflammation is seen in many chronic illnesses, including chronic kidney disease (CKD). We have recently reported on beneficiary effects of anti-inflammatory treatment in the interleukin (IL-) 1 pathway on anemia as well as CKD extent in a mouse model. Colchicine has been shown to have beneficiary effects in several inflammatory conditions through various mechanisms, including inhibition of tubulin polymerization as well as caspase-1-mediated IL-1 activation. Methods: Kidney injury (KI) was induced by administering an adenine diet to 8-week-old C57BL/6J mice treated with colchicine (Col) (30 µg/kg) or saline injections for 3 weeks, generating 4 groups: C, Ccol, KI, and KIcol. Results: KI animals had an increase in inflammation indices in the blood (neutrophils), liver, and kidneys (uromodulin, IL-6, pSTAT3). Increased kidney tubulin polymerization and caspase-1 in KI, as well as kidney Mid88 and IRAK4 (downstream of IL-1), were inhibited in KIcol. Kidney macrophage and polymorphonuclear infiltration (positive for F4/80 and MPO, respectively), the percentage of fibrotic area, and TGFβ mRNA levels were lower in KIcol versus KI. Conclusions: Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI. Given its reported safety profile for long-term anti-inflammatory therapy without increasing infection tendency, it may serve as novel therapeutic approach in CKD.
Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report
Authors: Osorio-Toro Luis Miguel , Bonilla-Bonilla Diana Marcela , Escobar-Dávila Santiago Leandro , Quintana-Ospina Jhon Herney , Melo-Burbano Luis Alvaro , Benitez-Escobar Edith Norela , Galindes-Casanova Duván Arley , Daza-Arana Jorge Enrique , Rivas-Tafurt Giovanna Patricia
Published: August 2023

We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response.
Course of Duration and Trigger Factors of Vertigo Attacks in Patients with Benign Recurrent Vertigo, Menière’s Disease, or Vestibular Migraine
Authors: Uijttewaal Maarten C. , van Leeuwen Roeland B. , Colijn Carla , Schermer Tjard R.
Published: August 2023

Introduction: Benign recurrent vertigo (BRV), Menière’s disease (MD), and vestibular migraine (VM) show many similarities with regard to the course of vertigo attacks and clinical features. In this paper, we elaborate on the decreasing frequency of vertigo attacks observed in a previous study from our group by exploring changes in the duration and trigger factors of vertigo attacks in patients with BRV, MD, or VM. Methods: For this 3-year prospective cohort study in our tertiary referral center we recruited patients with a confirmed diagnosis of BRV, MD, or VM by a neurologist and otorhinolaryngologist in our center in 2015–2016. A study-specific questionnaire was used to assess the usual duration of vertigo attacks and their potential triggers every 6 months. Main outcome measures were changes in duration and trigger factors of vertigo attacks in the subgroups of patients with persisting attacks, which were analyzed using repeated measures logistic regression models. Results: 121 patients were included (BRV: n = 44; MD: n = 43; VM: n = 34) of whom 117 completed the 3-year follow-up period and 57 (48.7%) kept reporting vertigo attacks at one more follow-up measurements. None of the diagnosis groups showed statistically significant shortening of attack duration at the subsequent annual follow-up measurements compared to baseline. At baseline, stress and fatigue being reported as triggers for attacks differed significantly between the three groups (stress: BRV 40.9%, MD 62.8%, VM 76.5%, p = 0.005; fatigue: BRV 31.0%, MD 48.8%, VM 68.8%, p = 0.003). In the VM group, a consistent reduction of stress and fatigue as triggers was observed up until the 24- and the 30-month follow-up measurements, respectively, with odds ratios (ORs) ranging from 0.15 to 0.33 (all p < 0.05). In the MD group, a consistent reduction of head movements as trigger was observed from the 24-month measurement onward (ORs ranging from 0.07 to 0.11, all p < 0.05). Conclusion: Our study showed no reduction in vertigo attack duration over time in patients with BRV, MD, and VM who remain to have vertigo attacks. In VM and MD patients with persisting vertigo attacks stress, fatigue and head movements became less predominant triggers for vertigo attacks.
The Nature and Availability of Mental Health Services in Arab Gulf Countries: A Scoping Review
Authors: Alanazi Tariq Noman M. , McKenna Lisa , Buck Miranda
Published: August 2023

Introduction: Given that mental health services are developing across Gulf Cooperation Council (GCC) or Arab Gulf countries, there is a need to examine the nature of these services to explore how they are developing, expanding, or evolving. This study aimed to explore what is known about the scope and nature of available mental health services for adult populations in Arab Gulf countries. Methods: This scoping review was informed by the 2005 methodological framework of Arksey and O’Malley. The databases MEDLINE, PsycINFO, CINAHL, ProQuest Central, EMBASE, Web of Science/Scopus, DOAJ, and Saudi Digital Library were searched for studies published between 2011 and 2021. Studies were included if they focused on reported scope and nature of available mental health services for adult populations in Arab Gulf countries, excluding those related to drug and alcohol, intellectual disability, and behavioural problems. Results: The search identified 8,884 articles, from which a total of 28 were included in the final review. The majority of studies were from the Kingdom of Saudi Arabia, with fewer studies from other Arab Gulf countries, and only one conducted in Bahrain. Mental health services described were primarily referral services, psychotherapy and cognitive behavioural therapy, telepsychiatry and mobile health services, screening, early detection and management of depression and anxiety, and other mental health services. Conclusion: This review revealed that the most available and utilised mental health services in Arab Gulf countries for treating adult mental disorders are psychotherapy and cognitive behavioural therapy, telepsychiatry and mobile health services, especially during the COVID-19 pandemic.
Determination of the Relationship between Globus-Type Complaints and COVID-19 Anxiety in Adult Cases with COVID-19
Authors: Akbaş Yasemin , Atalık Güzide , Yılmaz Metin , Bozdayi Gülendam
Published: August 2023

Introduction: Besides generalized symptoms, patients with COVID-19 also show otolaryngological (ENT) symptoms. Globus is one of these symptoms. Anxiety problems may accompany the disease, as well. This study investigated the relationship between globus symptoms and COVID-19 anxiety in patients diagnosed with COVID-19. Methods: The Turkish version of Glasgow-Edinburgh Throat Scale (GETS-T) and Coronavirus Anxiety Scale (CAS) was used to investigation of the relationship between globus symptoms and COVID-19 anxiety in patients diagnosed with COVID-19. They responded to the GETS-T for the evaluation of throat symptoms and determination of their severity. Additionally, it examined the level of dysfunctional anxiety associated with the coronavirus in COVID-19 patients by using the CAS. Data were collected through telephone interviews. There were 220 participants in a prospective cross-sectional study (110 COVID-19 patients and 110 non-COVID-19). Results: Results show the GETS-T total score to be significantly higher in the COVID-19 group than in the non-COVID-19 group (p < 0.001). As the GETS-T total score increased, CAS total score also increased significantly in the COVID-19 group. Total scores of GETS-T and CAS were found to be lower in the post-acute period than in the acute period in the COVID-19 group (p < 0.001). Conclusion: This study confirms that globus-type symptoms may be present in the clinical appearance of COVID-19 infection. In addition, the results support the opinion held in the academic literature that there are positive correlations between globus sensation and psychosomatic etiology. Furthermore, the study concludes that the symptoms generalized as globus-type symptoms, which include sore throat, the feeling that something is stuck in the throat, and the inability to clear the throat, decrease and almost disappear after the first month of the disease.
Passado-presente-passado em vias de construção de futuro: O que podemos apre(e)nder com Black is King?
Authors: Oliveira Vinicius , Euclides Maria Simone
Published: August 2023

Este artigo é fruto da monografia intitulada Entre Colmeias & Quilombos, e visa se debruçar nos elementos afrocentrados e afrorreferenciados presentes na obra The Gift/Black is King, da multiartista Beyoncé. Na costura entre a Afrocentridade e a Antropologia, junto da proposta metodológica de análise de conteúdo, intenta compreendemos a arte, principalmente a partir das músicas e o álbum, como o locus tensionadores e potencialmente propositivos das humanidades negras, apontando ao mesmo tempo, o resgate de elementos na ancestralidade africana, em vias de tessitura do presente e do futuro em narrativas afrofuturistas. A obra de Beyoncé aqui analisada, apresenta alternativas outras para pessoas negras que encerra com o status quo racista, universalizante e, portanto, eurocêntrico. Assim, discutimos Sankofa e o movimento do Afrofuturismo em consonância com elementos presentes nas músicas de Beyoncé que os ressignifica no presente ao tecer narrativas para a realização humana negra, resultando em autoestima e afrorreferência em sujeitos/as/es africanos/as/es em diáspora ou não, permitindo outras acepções sobre o mundo que se afastam das definições de ser e estar calcadas no ser ocidental-colonial.
Perspectivas do desenvolvimento nacional sustentável em licitações públicas: um estudo a partir da revisão integrativa
Authors: Carvalho Amanda Bezerra de
Published: August 2023

O artigo visa apresentar o desenvolvimento nacional sustentável em licitações públicas, a partir da busca por artigos publicados em periódicos científicos indexados nas bases SciELO e Google Scholar durante os anos de 2015 a 2021. Para tanto, utilizou-se o método da revisão integrativa, empregando como descrito-res “desenvolvimento sustentável”, “sustentabilidade”, “compras públicas” e “licitações públicas” com o auxílio do conectivo “AND”, estabelecendo o parâmetro de pesquisas publicadas durante os anos de 2015 a 2021, no idioma português. Empregaram-se no tratamento dos dados três formas de análise através do Software Iramuteq: a Classificação Hierárquica Descendente, a Análise de Similitude e a Nuvem de Pala-vras. Os resultados permitem inferir que existe uma tímida publicação de artigos científicos brasileiros re-lacionados à implementação prática das dimensões do Desenvolvimento Nacional Sustentável no plano prático das licitações públicas. As contribuições promovidas nesse estudo reafirmam a necessidade de maiores aprofundamentos sobre o plano prático da implementação dos princípios e dimensões que anco-ram o Desenvolvimento Sustentável em licitações, diante da constante emergência por mudanças que este-jam em harmonia com o planeta.
Verdade e fake news: um olhar a partir do direito fundamental de acesso à informação
Authors: Sparemberger Raquel Fabiana Lopes , Silva Alisson Jordy Martins da
Published: August 2023

Este artigo foi produzido a partir da metodologia dedutiva, com análise bibliográfica de artigos e de trabalhos acadêmicos das áreas de Ciências Jurídicas e sociais. Seu principal objetivo é discorrer sobre as relações existentes entre os direitos fundamentais de transparência pública e acesso às informações em uma sociedade cotidianamente afetada pela veiculação de notícias e informações falsas, compartilhadas não só por particulares, mas também pelos próprios agentes políticos.
Saneamento básico e regulação no Brasil: desvendando o passado para moldar o futuro
Authors: Vilarinho Cíntia Maria Ribeiro , Couto Eduardo de Aguiar do
Published: August 2023

Este artigo apresenta uma revisão bibliográfica da história do saneamento básico no Brasil e sua regulação. Foi realizado por meio de referências que abordam desde o período de colonização até a atualização da Lei nº 11.445/2205, conhecida como o Marco Legal do setor, por meio da Lei nº 14.026/2020, apresentando os decretos publicados até o ano de 2023. A história das políticas públicas de saneamento no Brasil demonstra a transformação de uma atividade que se iniciou de modo incipiente, baseada em soluções individuais apropriadas à época, chegando a arranjos complexos de soluções coletivas que utilizam modelos de prestação pública e privada. Apesar dos avanços, desafios persistem, como a falta de acesso adequado à água tratada e ao esgotamento sanitário que ainda afeta muitas pessoas. A regulação precisa ser aprimorada e padronizada para abranger todos os municípios, e colaborar para uma gestão holística que considere a saúde, o meio ambiente e o direito à água. O estudo contribui para a criação de um registro histórico sobre o saneamento básico no Brasil, fornecendo um contexto relevante para pesquisas futuras e o desenvolvimento de políticas públicas eficazes.
Os contratos administrativos à luz do código de defesa do consumidor
Authors: Cosenza Ana Margareth Moreira
Published: August 2023

O presente artigo científico analisa a aplicação subsidiária ou principal da disciplina protetiva do Código de Defesa do Consumidor (CDC-Lei nº 8.078/1990) ao regime jurídico de contratações públicas, regido pe-la Lei nº 8.666/1993 e Lei 10.520/2002 ou pela atual e substitutiva Lei nº14.133/2021. Investiga-se quan-to à possibilidade de haver casos em que contratos administrativos possam ser classificados como con-tratos de consumo, sendo submetidos ao CDC. Para tanto, foram consultados os principais doutrinadores do ramo, jurisprudência e materiais bibliográficos, sopesando os impactos econômicos dessas interpreta-ções no equilíbrio econômico-financeiro e na segurança jurídica de tais contratos administrativos. Anali-sou-se o peso do pacote de responsabilidade consumerista, imputado aos fornecedores, sobre os custos que formam os preços dos bens e serviços comuns disponibilizados no mercado, concluindo-se que mui-tos contratos administrativos celebrados por entidades estatais com personalidade jurídica de Direito Pú-blico não são dedicados a atos negociais. Logo, estão inseridos em relações jurídicas com relevante grau de vulnerabilidade técnica, jurídica e fática, justificando a aplicação constitucional do Direito do Consumi-dor em benefício dos recursos públicos.
Shared Decision-Making and Cardiovascular Health: A Scientific Statement From the American Heart Association
Authors: Dennison Himmelfarb Cheryl R. , Beckie Theresa M. , Allen Larry A. , Commodore-Mensah Yvonne , Davidson Patricia M. , Lin Grace , Lutz Barbara , Spatz Erica S. ,   on behalf of the American Heart Association Council on Cardiovascular and Stroke Nursing,   on behalf of the American Heart Association Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Quality of Care and Outcomes Research; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; Council on Epidemiology and Prevention; and Stroke Council
Published: August 2023

Shared decision-making is increasingly embraced in health care and recommended in cardiovascular guidelines. Patient involvement in health care decisions, patient-clinician communication, and models of patient-centered care are critical to improve health outcomes and to promote equity, but formal models and evaluation in cardiovascular care are nascent. Shared decision-making promotes equity by involving clinicians and patients, sharing the best available evidence, and recognizing the needs, values, and experiences of individuals and their families when faced with the task of making decisions. Broad endorsement of shared decision-making as a critical component of high-quality, value-based care has raised our awareness, although uptake in clinical practice remains suboptimal for a range of patient, clinician, and system issues. Strategies effective in promoting shared decision-making include educating clinicians on communication techniques, engaging multidisciplinary medical teams, incorporating trained decision coaches, and using tools (ie, patient decision aids) at appropriate literacy and numeracy levels to support patients in their cardiovascular decisions. This scientific statement shines a light on the limited but growing body of evidence of the impact of shared decision-making on cardiovascular outcomes and the potential of shared decision-making as a driver of health equity so that everyone has just opportunities. Multilevel solutions must align to address challenges in policies and reimbursement, system-level leadership and infrastructure, clinician training, access to decision aids, and patient engagement to fully support patients and clinicians to engage in the shared decision-making process and to drive equity and improvement in cardiovascular outcomes.
Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation
Authors: Bakhoum Christine Y. , Madala Samantha , Lando Leonardo , Yarmohammadi Adeleh , Long Christopher P. , Miguez Sofia , Chan Alison X. , Singer Maxwell , Jin Andrew , Steren Ben J. , Adabifirouzjaei Fatemeh , Goldbaum Michael H. , DeMaria Anthony N. , Sarraf David , Bakhoum Mathieu F.
Published: August 2023

Background

We previously demonstrated that retinal ischemic perivascular lesions (RIPLs), which are indicative of ischemia in the middle retina, may be a biomarker of ischemic cardiovascular disease. In this study, we sought to determine the relationship between RIPLs and atrial fibrillation, a common source of cardiac emboli.

Methods and Results

In this case‐control study, we identified individuals between the ages of 50 and 90 years who had undergone macular spectral domain optical coherence tomography imaging. Individuals with atrial fibrillation were identified, and age‐ and sex‐matched individuals from the same pool, but without a diagnosis of atrial fibrillation, were selected as controls. Spectral domain optical coherence tomography scans were reviewed by 3 independent and masked observers for presence of RIPLs. The relationship between RIPLs and atrial fibrillation was analyzed using multivariable logistic regression models. There were 106 and 91 subjects with and without atrial fibrillation, respectively. The percentage of subjects with RIPLs was higher in the atrial fibrillation group compared with the control group (57.5% versus 37.4%;
P
=0.005). After adjusting for age, sex, smoking history, hypertension, diabetes, coronary artery disease, carotid stenosis, stroke, and myocardial infarction, the presence of RIPLs was significantly associated with atrial fibrillation, with an odds ratio of 1.91 (95% CI, 1.01–3.59).

Conclusions

RIPLs are significantly associated with atrial fibrillation, independent of underlying ischemic heart disease or cardiovascular risk factors. This association may inform the diagnostic cardiovascular workup for individuals with RIPLs incidentally detected on optical coherence tomography scan of the macula.
Hiding in plain sight: two new species of diminutive marsupial (Dasyuridae: Planigale) from the Pilbara, Australia
Authors: UMBRELLO LINETTE S. , COOPER NORAH K. , ADAMS MARK , TRAVOUILLON KENNY J. , BAKER ANDREW M. , WESTERMAN MIKE , APLIN KEN P.
Published: August 2023

Many of Australia’s smaller marsupial species have been taxonomically described in just the past 50 years, and the Dasyuridae, a speciose family of carnivores, is known to harbour many cryptic taxa. Evidence from molecular studies is being increasingly utilised to help revise species boundaries and focus taxonomic efforts, and research over the past two decades has identified several undescribed genetic lineages within the dasyurid genus Planigale. Here, we describe two new species, Planigale kendricki sp. nov. (formerly known as ‘Planigale 1’) and P. tealei sp. nov. (formerly known as ‘Planigale sp. Mt Tom Price’). The two new species have broadly overlapping distributions in the Pilbara region of Western Australia. The new species are genetically distinct from each other and from all other members of the genus, at both mitochondrial and nuclear loci, and morphologically, in both external and craniodental characters. The new species are found in regional sympatry within the Pilbara but occupy different habitat types at local scales. This work makes a start at resolving the cryptic diversity within Planigale at a time when small mammals are continuing to decline throughout Australia.
A new species of Xylodes Waterhouse from Madagascar, with a key to the genera of the tribe Ptinini from Madagascar, Mascarenes and adjacent regions, and a key to species of Xylodes, subgenus Diegous (Coleoptera: Ptinidae)
Authors: ZAHRADNÍK PETR , TRÝZNA MILOŠ , RAZAFINDRANAIVO VICTOR
Published: August 2023

A new species, Xylodes (Diegous) korinae Zahradník & Trýzna sp. nov. (Bostrichoidea: Ptinidae, Ptininae, Ptinini), from east Madagascar is described, illustrated and compared with other species from the subgenus Diegous Pic, 1896. Male and female genitalia are studied and illustrated. Keys to morphologically similar genera from Madagascar and adjacent areas, to both subgenera of the genus Xylodes Waterhouse, 1876, and to all species of the subgenus Diegous are presented. Ecological notes, including photographs of habitats of the new species are also provided.
The Smart City as Policy Concept in the Arab World: A Critical Research into the Strategic Visions of Urban Development in Abu Dhabi
Authors: K’Akumu O.A. , Alhamoudi Abdullah Mazen
Published: August 2023

This article reviews the smart city as a policy concept in Abu Dhabi. It conceptualizes smart city development goals into urban and extra-urban and review smart city development programmes in terms of ex-post and ex-ante. Extra-urban refers to development goals that go beyond the spatial or conceptual boundaries of the city. This will help to demonstrate how the pursuit of extra-urban may compromise the attainment of urban development goals. The paper uses Abu Dhabi as the frontline city in the Middle East and North Africa (MENA) region in the race to attain the smart city status, having led consistently in the McKinsey Global Institute poll of 2018 and the global indexing exercises conducted by the International Institute for Management Development and Singapore University of Technology and Design in 2020 and 2021. The study has used qualitative document analysis method to review policy documents regarding the smartification initiatives in Abu Dhabi. The analysis reveals that ex-post programmes are more urban dweller oriented or urban centred with programmes involving the digitization of government services and free Wi-Fi connectivity in public transport, while ex-ante smartification programmes (as seen in the development of Masdar city) tend to be extra-urban, elitist and global in nature but do not take into account social sustainability.
Role of graphene concentration on electrochemical and tribological properties of graphene-poly(methyl methacrylate) composite coatings
Authors: Salasel Amir Reza , Bhowmick Sukanta , Riahi Reza , Alpas Ahmet T
Published: August 2023

This study aims to investigate the influence of graphene nanoplatelet (GNP) concentration on the electrochemical and tribological properties of GNP-poly(methyl methacrylate) (PMMA) composite coatings. GNP-PMMA coatings were prepared with varying GNP concentrations (0.5, 1.0, 3.0, and 5.0 wt %) using the drop-casting method onto AA6061 aluminum alloy substrates. Results showed that the addition of 1.0 wt % GNP increased the tensile strength of PMMA but further increase reduced the tensile strength and fracture strain of the composites. Permeability studies indicated that 1.0GNP-PMMA had the lowest water vapour transition rate. All GNP-PMMA coatings showed a higher coating resistance and impedance modulus at the lowest frequency compared to neat PMMA with 1.0GNP-PMMA having the highest |Z|0.01 Hz value in comparison to the composites with higher GNP concentrations. According to Raman mapping, an increase in the concentration of GNP in the composite resulted in the agglomeration of graphene, which caused the debonding of the graphene-PMMA interfaces and also resulted in a higher number of shear fronts and other defects on the fracture surface that reduced barrier properties of graphene. The specific wear rate of 1.0GNP-PMMA was lower than that of neat PMMA, indicating improved wear resistance. The coefficient of friction was lowest for 5.0GNP-PMMA, although this was due to a higher amount of material being transferred to the counterface. Accordingly, optimizing the GNP concentration enables the development of high-performance PMMA coatings with enhanced strength, improved barrier properties, and reduced wear rates, making them well-suited for applications such as corrosion protection and tribological coatings.
Nationalist propaganda and support for war in an authoritarian context: Evidence from China
Authors: Liu Dongshu , Shao Li
Published: August 2023

How can autocrats boost public support for wars? Previous studies have suggested that in democracies, the public changes its war attitude either through rational cost–benefit calculations or simply by following cues from political elites. This article argues that autocrats can follow a similar logic to manipulate public support for war via nationalist propaganda. Based on two online survey experiments with textual and musical propaganda materials in mainland China, this article finds that nationalist propaganda bolsters public support for war, regarding a potential military conflict across the Taiwan Strait. Evidence shows that propaganda increases respondents’ expected return on winning wars, arousing national pride, and reducing respondents’ sensitivity to war costs. However, people’s confidence in winning a given war remains unchanged. These findings suggest that nationalist propaganda can boost support for war by increasing the perceived benefits of the war and reducing their sensitivity toward war costs without changing their perceived probability of winning. It also demonstrates that nationalist propaganda does not need to be explicit about war in order to boost war support in autocracies. This study also reveals the changing dynamic of public opinions in China regarding war for unification over the Taiwan Strait, which has significant implications for security and geopolitics in East Asia.
Economic evaluation of increased nitrogen fertiliser prices on risk-efficient fertiliser applications
Authors: Matthews Nicolette , Grové Bennie
Published: August 2023

World market prices for food and fertiliser have increased significantly, leading to concerns about the impact of high food prices on food security. Therefore, the article investigates the effect of increased nitrogen fertiliser prices on optimal fertiliser use decisions for maize under irrigation, considering the uncertainty regarding maize crop yield response to nitrogen fertiliser application in different production years. The results showed that as the fertiliser price increases from 5 to 19 ZAR/kg, the amount of fertiliser applied decreases from the maximum of 220 kg/ha to around 100 kg/ha. Increased N fertiliser prices would decrease the amount of fertiliser applied, although the response is determined by the combination of fertiliser price, soil used, fertiliser application method and risk behaviour. The expected yields estimated for the optimal nitrogen fertiliser levels showed flat yield responses to decreased fertiliser application levels. The reduction in crop yields due to reduced fertiliser use is never more than 300 kg/ha. The results suggest that the soil used for production does not greatly impact the crop response since the optimal fertiliser decision is adjusted to ensure the maximum possible expected yield. However, the decision to use a single or split application does impact the optimal fertiliser use decision with higher application levels for a split application and a slightly lower crop yield response. The main conclusion is that increased nitrogen fertiliser prices would decrease the amount of fertiliser applied; however, the effect on expected crop yield would be minimal.
An Endoscopic Endonasal Attempt at Pediatric Meningoencephalocele Repair
Authors: Raskin Jonathan , Borrelli Michela , Wrobel Bozena
Published: August 2023

Meningoencephalocele is an abnormal skull base protrusion of fluid, brain tissue, and meninges that can lead to nasal obstruction, meningitis, and Cerebrospinal Fluid (CSF) rhinorrhea. This condition can be managed operatively through an open craniotomy or a less invasive endoscopic approach. Here, we report a case of an 18-month-old female who presented with a meningoencephalocele that was part of the Sakoda complex, a rare neurosurgical phenomenon consisting of meningoencephalocele, agenesis of the corpus callosum, and cleft lip/palate. The patient was initially treated with the endoscopic transsphenoidal approach with subsequent open craniotomy.
Effect of Nasal Submucosal Injection of Low-concentration Epinephrine on Visual Field Visualization in Endoscopic Sinus Surgery: A Systematic Review and Meta-analysis
Authors: Zhang Bi , Zhuang Liye , Cai Chang , Qi Yong
Published: August 2023

Objective: To determine whether nasal submucosal injection of low-concentration epinephrine improved the surgical field visualization and physician satisfaction compared to placebo or without intervention. Methods: A literature search of PubMed, Scopus, Web of Science, Cochrane library, China National Knowledge Infrastructure, and Wanfang Database was conducted from inception to January 10, 2023. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Meta-analyses were performed using Review Manager (RevMan version 5.3; the Cochrane Collaboration). Quality was assessed by 2 reviewers using the Cochrane Risk of Bias Tool. And we used funnel plots to visually assess the risk of publication bias. Results: We included a total of 11 studies with 492 patients, all of which were randomized controlled trials. Among the studies, 4 had a low risk of bias, 4 had a moderate risk of bias, and 3 had a high risk of bias. Five studies reported visual bleeding grade in the surgical field ( P = 0.07) and total blood loss ( P = 0.16), 8 studies reported preoperative baseline heart rate ( P = 0.58) and baseline mean arterial pressure (MAP) ( P = 0.78), and 9 studies reported intraoperative heart rate ( P = 0.27) and MAP ( P = 0.56), which showed no significant differences in these parameters between the 2 groups. None of these outcomes were statistically significant between the epinephrine group and the control group. Conclusion: There is insufficient evidence to support the nasal submucosal application of low-concentration epinephrine to improve surgical field dryness and reduce total surgical bleeding.