bluuebunny/crossref_metadata_2025 huggingface dataset:
The mediating role of compassion fatigue between perceived organization support and caring behavior among outpatient nurses in China: a cross-sectional study
Authors: Liu Xingxing , He Fang , Tian Tian , Zhang Jun , Ji Yuanjiao , Zhong Yuexia
Published: August 2024

Background
The caring behaviors of outpatient nurses play a crucial role in improving the quality of care in hospitals. Work resources and personal psychological resources have a significant impact on nurses’ caring behavior. Previous research has shown that perceived organizational support and compassion fatigue are linked to nurses’ caring behaviors. However, the specific relationship among these variables is less clear in the context of outpatient nurses working in high-stress environments.
Methods
A convenience sampling method was utilized to recruit 413 outpatient nurses from six tertiary hospitals in Xi’an, China, as research subjects between November 2023 and January 2024. The questionnaires used in the study included a sociodemographic questionnaire, the Perceived Organizational Support Scale, the Chinese version of the Compassion Fatigue Brief Scale, and the Chinese version of the Caring Behavior Scale. Data analysis involved descriptive statistics, Mann-Whitney U test, Kruskal-Wallis H rank-sum test, Spearman correlation analysis, and the PROCESS macro model 4.
Results
Spearman correlation analysis indicated a significant negative correlation between perceived organizational support and compassion fatigue (ρ=-0.547, P<0.01), as well as a significant positive correlation between perceived organizational support and caring behavior (ρ=0.469, P<0.01). Moreover, there was a significant negative correlation between compassion fatigue and caring behavior (ρ=-0.641, P<0.01). Subsequent mediation analysis demonstrated that compassion fatigue partially mediated the relationship between perceived organizational support and caring behaviors. The overall impact of perceived organizational support on caring behavior (β=0.363) encompasses both its direct influence (β=0.131) and the indirect impact mediated by compassion fatigue (β=0.232). The mediating effect accounts for 63.9% of the total effect.
Conclusion
Compassion fatigue acts as a partial mediator in the relationship between perceived organizational support and the caring behavior of outpatient nurses. It is essential for nursing managers to effectively manage both the work resources and personal psychological resources of outpatient nurses to improve their caring behaviors in high-stress settings. By improving nurses’ organizational support resources, we can reduce the depletion of their personal psychological resources and alleviate negative emotions such as compassion fatigue. This, in turn, can improve nurses’ caring behavior and ultimately enhance the overall quality of nursing services in the hospital.
A New Apparatus for Seepage and Internal Erosion Soil Column Tests in Geotechnical Centrifuge
Authors: Guo Chang , Huang Bo , Fan Jiying , Zhang Wenyue , Tang Yao
Published: August 2024

Understanding the hypergravity effect on seepage and internal erosion is the essential precondition for dam hydraulic disaster modeling using geotechnical centrifuges. Soil column testing is useful to bridge this knowledge gap, but previous attempts did not provide adequate functionality in centrifuge environments. This study develops a centrifuge-available apparatus for seepage and internal erosion soil column tests (CASIE). CASIE ensures a consistent and stable circulating water supply with no less than 34 000 ml/min at 80 g via double-bowl upstream and downstream water tanks and a vertical, multistage centrifugal pump. The hydraulic gradient can be controlled by adjusting the elevation of the upstream water tank using a servo lifting system with a vertical displacement range of 1.2 m and a maximum vertical speed of 155 mm/min. A rigid-wall permeameter is developed for multiple applications in soil column tests for seepage and internal erosion. The flowrate through the specimen can be measured using four parallel-installed oval gear flowmeters with a large measurement range of 10–10 000 ml/min. To validate the capabilities of CASIE, two suffusion (one form of internal erosion) tests were conducted at 1 g and 30 g. The results reveal that the scaling factor for the critical hydraulic gradient of 30 g to 1 g is 1/10. It is much less than the predicted value of 1, indicating that suffusion failure is more readily triggered in the hypergravity environment.
LsfA Peroxiredoxin and Ascorbate interact in the response of Pseudomonas aeruginosa to H2O2
Authors: Netto Luis , Silva Rogerio Aleixo , Domingos Renato , Trujillo Madia , Machado Luciene , de Oliveira Cristiano , Baldini Regina
Published: August 2024

Pseudomonas aeruginosa, a leading cause of hospital-acquired infections, triggers host defenses, including oxidant release by phagocytes. Targeting bacterial antioxidants could reduce pathogen infectivity. This study investigates LsfA, a 1-Cys peroxiredoxin (Prx) involved in P. aeruginosa virulence. LsfA efficiently reduces various peroxides (106 - 107 M-1.s-1), while exhibited hyperoxidation resistance. Despite its substrate oxidizing promiscuity, LsfA displayed specific reduction by ascorbate. Moreover, the elucidation of the LsfA’s crystallographic structures in the reduced and sulfonic acid states at 2.4 and 2.0 Ǻ resolutions, respectively, unveiled possible ascorbate-binding residues. Small-angle X ray scattering (SAXS) and size-exclusion chromatography (SEC) confirmed LsfA is a dimer regardless of its oxidative state. Microbiological assays, including a real-time analysis employing Hyper7, a genetically encoded probe showed that ascorbate enhanced H2O2 removal in a LsfA-dependent manner. Hence, our integrated structural, biochemical, and microbiological analyses underscored the significance of the ascorbate–LsfA pathway in P. aeruginosa response to H2O2.
Comparison of self-reported and physiological sleep quality from consumer devices to depression and neurocognitive performance
Authors: Akre Samir , Cohen Zachary , Welborn Amelia , Zbozinek Tomislav , Balliu Brunilda , Craske Michelle , Bui Alex
Published: August 2024

This study examines the relationship between self-reported and physiologically measured sleep quality in individuals with depression and its impact on neurocognitive performance. Using data from 249 participants with medium to high depression monitored over 13 weeks, sleep quality was assessed via retrospective self-report and physiological measures from consumer smartphones and smartwatches. Correlations between self-reported and physiological sleep measures were generally weak. Machine learning models revealed that self-reported sleep quality could detect all depression symptoms measured on the Patient Health Questionnaire-14, whereas physiological measures only detected “sleeping too much” and low libido. Notably, only self-reported sleep disturbances correlated significantly with neurocognitive performance. Physiological sleep was able to detect changes in the self-reported sleep quality domains of sleep medication use and sleep latency. These findings emphasize that self-reported and physiological sleep quality are not measuring the same construct, and both are important to monitor when studying sleep quality in relation to depression.
Causal Relationship Between Inflammatory Cytokines and Polycystic Ovary Syndrome: A Bidirectional Mendelian Randomization Study
Authors: Tian Danling , Chen Jinfeng , Liu Liang
Published: August 2024

Polycystic ovary syndrome (PCOS) is defined as a chronic low-grade inflammatory reproductive endocrine disorder. PCOS can induce various metabolic disorders, which are associated with a state of mild and slow-acting inflammation. Nevertheless,it‘s uncertain that the causation about PCOS and inflammatory factors. The causality between inflammatory cytokines and PCOS was analyzed by bidirectional Mendelian randomization (MR) in this current probe. We performed an interactive MR study to assess the causal relationships between 91 inflammatory cytokines and PCOS using Genome Wide Association Study (GWAS) data. We underwent dual-sample MR analysis with inverse variance weights (IVW) as the predominant MR methodology with multiple validity and heterogeneity analyses. MR-Egger, weighted median, simple mode, weighted mode and MR-PRESSO were analyzed as multiple likelihood sensitivity analyses to enhance the final results.The results came out interleukin-1-alpha (IL-1A) levels (odds ratio [OR] = 1.051, 95% fiducial interval [95% CI] = 1.009–1.095, P = 0.02) and oncostatin-M (OSM) levels ( [OR] = 1.041, [95% CI] = 1.001–1.082, P = 0.04) were positively associated with the development of PCOS. Moreover, interleukin-7 (IL-7) levels ([OR] = 0.935, [95% CI] = 0.884–0.989, P = 0.02); interleukin-15 receptor subunit alpha (IL15RA) levels ([OR] = 0.959, [95% CI] = 0.929–0.99, P = 0.01); and C-X-C motif chemokine 11 (CXCL11) levels ([OR] = 0.959, [95% CI] = 0.922–0.996. P = 0.03) were strongly negatively associated with PCOS. However, we did not find any strong positive results in the reverse analysis, suggesting that although inflammatory factors contribute to the pathogenesis of PCOS, PCOS itself does not trigger inflammatory factor production.Our study provides genetic evidence for the connection between systemic inflammatory regulators and PCOS. Treatments targeting specific inflammatory factors may help to mitigate the risk of PCOS. The levels of five of the 91 inflammatory factors included in this study, namely, IL1A and OSM, were associated with PCOS. IL1A and OSM contribute to the progression of PCOS while IL-7, IL15RA, and CXCL11 levels are negatively correlated with the development of PCOS.
Improving Artificial Neural Network Performance with Zero Initialization
Authors: Seo Jongwoo , Koh Wuhyun
Published: August 2024

This study explores zero initialization in artificial neural networks, mimicking synaptic resetting during sleep. Despite the common belief that zero initialization hinders learning by causing identical outputs, our approach diversifies outputs by initializing weights to zero and biases to random values. We evaluated models on Modified National Institute of Standards and Technology (MNIST), Canadian Institute for Advanced Research (CIFAR)-10, and CIFAR-100 datasets using multilayer perceptrons (MLPs), convolutional neural networks (CNNs), residual networks (ResNets), vision transformers (ViTs), and multilayer perceptron mixers (MLP-Mixers). Results showed mixed outcomes: while zero initialization can hinder learning in some cases, it can also match or surpass random initialization in others, especially in plain neural network configurations. Among contemporary deep learning models, MLP-Mixers with zero initialization matched the performance of fully randomly initialized counterparts, despite half of the learnable parameters being set to zero. This study challenges the conventional view that zero initialization inherently degrades neural network performance.
Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review
Authors: Goldsworthy Adrian , O’Callaghan Liam , Blum Ciara , Horobin Jarod , Tajouri Lotti , Olsen Mathew , Bruggen Natalia Van Der , McKirdy Simon , Alghafri Rashed , Tronstad Oystein , Suen Jacky , Fraser John F
Published: August 2024

Background
The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease. This systematic scoping review provides a comprehensive investigation of studies examining the impacts of MNPs on the human cardiovascular system.
Methods
Five databases (PubMed, SCOPUS, CINAHL, Web of Science and EMBASE) were systematically searched.
Results
Thirty-four articles were identified, six of which investigated the presence of MNPs within the human cardiovascular system, including atherosclerotic plaques, saphenous vein tissue, and venous blood. The effect of MNPs on cell lines suggest MNPs are cytotoxic, immunotoxic, and genotoxic.
Discussion
The findings of this review, when evaluated together with additional studies utilising animal models, strongly suggest MNPs currently contribute to global cardiovascular morbidity and mortality. In particular, the ability of MNPs to induce endothelial damage, oxy-LDL formation, foam cell development and apoptosis, as well as altering the clotting cascade, has potential implications for vascular diseases. In addition, MNPs may play a role in the aetiology and progression of congenital heart abnormalities, infective pathologies and cardiomyopathies.
Conclusion
Despite an increasing awareness of the ability of MNPs to result in cardiovascular disease and dysfunction, a limited amount of research has been conducted to date characterising the presence of MNPs in the human cardiovascular system. Research is required to understand the extent of this rapidly emerging issue and to develop strategies that will support clinicians to appropriately manage and educate their patients about this issue in the future.
AGE, PARITY AND STAGE OF CERVICAL CANCER AMONG CERVICAL CANCER PATIENTS ATTENDING ONCOLOGY DEPARTMENT AN OBSERVATIONAL CROSS SECTIONAL STUDY AT JINNAH POSTGRADUATE MEDICAL CENTER, KARACHI
Authors:   Medical Oncology Department, Jinnah Post Graduate Medical Centre (JPMC), Karachi, Pakistan., Hashmat Sana , Haider Ghulam ,   Medical Oncology Department, Jinnah Post Graduate Medical Centre (JPMC), Karachi, Pakistan., Ali Qazi Shayan ,   Nephrology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan., Shah Amra ,   Medical Oncology Department, Jinnah Post Graduate Medical Centre (JPMC), Karachi, Pakistan., Qureshi Areeba ,   Nephrology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.
Published: August 2024

Background: Identification of disease patterns in context of basic social demographic characteristics among cervical cancer patients in the local population or Pakistani women is of high importance to identify the women at high risk of disease. Objective: To determine the age, parity and stage of cervical cancer among cervical cancer patients attending oncology department at Jinnah Postgraduate Medical Center, Karachi. Methods: This prospective cross-sectional study was conducted in the Oncology Department of Jinnah Postgraduate Medical Center, Karachi during October 2023 to January 2024. In total 92 women of age 18 years or above, presenting with biopsy proven cervical cancer were recruited using random convenient sampling technique. Data was analyzed using SPSS version 24. Results: The mean age of study participants was 53.4 years + SD10.9 years. The highest proportion of cases were recorded between 47-57 years of age with a proportion of 37.0% (n=34). 62% (n=57) of all study participants had a history of multiparty with at least five or more children. 65% (n=60) of all the study participants were postmenopausal women. 59.8% (n=55) of all the study participants were found to have Stage-II and Stage-III disease at the time of diagnosis while Squamous Cell Carcinoma was the most frequent histopathological diagnosis type. Conclusion: The highest burden of cervical cancer is present among the women of age group 47 to 57 years. Cervical cancer was most prevalent among women with higher parity or having five or more children. Squamous cell carcinoma was the most frequent diagnosis while most patients were diagnosed at the stage-II of the disease.
REGIME ALIMENTAIRE DE BOOPS BOOPS, CEPHALOPHOLIS TAENIOPS ET PLECTORHINCHUS MEDITERRANEUS (POISSONS TELEOSTEENS) DES COTES SENEGALAISES
Authors:   Faculte des Sciences et Techniques (FST), Laboratoire de Biologie Evolutive, decologie et de Gestion desEcosystemes, Universite Cheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann., Dione Ayatoulaye , Ba Abdoulaye ,   Institut Fondamental dAfrique Noire-Cheikh Anta Diop (IFAN-CAD), Laboratoire de Biologie Marine,Senegal, BP 206 Dakar-Fann., Bonaventure Badji Luc ,   Institut Fondamental dAfrique Noire-Cheikh Anta Diop (IFAN-CAD), Laboratoire de Biologie Marine,Senegal, BP 206 Dakar-Fann.,   Institut Universitaire de Peche et dAquaculture (IUPA), Faculte des Sciences et Techniques (FST), UniversiteCheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann., Tidiane Ba Cheikh ,   Faculte des Sciences et Techniques (FST), Laboratoire de Biologie Evolutive, decologie et de Gestion desEcosystemes, Universite Cheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann.
Published: August 2024

Ce travail, nous a permis de determiner pour la premiere fois la taille de lechantillon requise pour etudier le regime alimentaire chez P. mediterraneus, B. boopset C. taeniops a partir de la courbe cumulative de diversite de Shannon-Weiner. Elle a ete estimee a 125 150 et 225 estomacs respectivement pour B. boops, C. taeniopset P. mediterraneus. Nous avons apporte egalement de precieuses informations sur le coefficient de vacuite et les types de proies chez ces trois especes.La voracite du predateur B. boops a ete prouvee par cette etude avec un coefficient de vacuite tres faible. Contrairement a ceux de C. taeniopset P. mediterraneus qui sont tres eleves. Dans le regime alimentaire de B. boops on note que les Teleosteens sont des proies preferentielles, les Crustaces et les Mollusques sont des proies complementaires, tandis que les Annelides sont des proies accidentelles. Le regime alimentaire chez C. taeniops des cotes senegalaises est assez varie. Il est essentiellement compose de crustaces, de Teleosteens, de mollusques, dinvertebres et de debris vegetaux. Les crustaces sont des proies preferentielles, les teleosteens sont des proies secondaires, les mollusques et les invertebres sont des proies complementaires, les debris vegetaux sont des proies accidentelles. La presence de vegetaux dans le regime alimentaire de C. taeniops nous pousse a le considerer comme un omnivore. Pour P. mediterraneusdes cotes senegalaises, letude du regime alimentaire montre que les Crustaces sont des proies preferentielles les Teleosteens sont des proies secondaires les Mollusques, les Echinodermes et les Detritus sont des proies complementaires les Annelides, les Cnidaires, les Invertebres, les Tuniciers et les Plathelminthes sont des proies accidentelles.
LIVED EXPERIENCES OF ACCOUNTANCY, BUSINESS AND MANAGEMENT (ABM) TEACHERS IN BUENASCAR, DIVISION OF AGUSAN DEL NORTE: BASIS FOR INTERVENTION
Authors:   Teacher II, Department of Education-Division of Agusan Del Norte, SHS in Carmen., Lusterio G. , Pasion R. ,   Assistant SHS Principal in Academics, Department of Education-Division of Butuan City, Tungao National High School.
Published: August 2024

This study investigated the challenges faced by senior high school (SHS) teachers in handling Accountancy, Business, and Management (ABM) subjects. Three public secondary schools were included in the study: Guinabsan National High School, Nasipit National Vocational School, and Senior High School in Carmen, Agusan del Norte. There were 16 participants in the key informant interview. A semi-structured interview guide (convenience sampling) was used to gather data. The quantitative data from the surveys was statistically analyzed using frequency and percentage. Thematic analysis and coding were used to interpret the qualitative data from the interviews to have a clear picture of the ABM teachers experiences, which ensures a comprehensive, reliable, and meaningful overall study outcome. The study found that while ABM teachers are dedicated, they lack subject-matter expertise due to limited ABM-specific training and a curriculum focused on theory rather than practical application. This, along with limited resources, hinders student learning and preparedness for business careers.
TRAUMATICISOLATED RADIAL HEAD DISLOCATION IN CHILDREN
Authors:   Servie de Traumatologie Orthopedie, Service de Pediatrie, Centre Hospitalier Moulaybelmehdilaayoune, Faculte de Medecine et de Pharmacie Laayoune, Maroc., Aznague Youness , Fadil Amal ,   Servie de Traumatologie Orthopedie, Service de Pediatrie, Centre Hospitalier Moulaybelmehdilaayoune, Faculte de Medecine et de Pharmacie Laayoune, Maroc., . Abdenasserchaoui ,   Servie de Traumatologie Orthopedie, Service de Pediatrie, Centre Hospitalier Moulaybelmehdilaayoune, Faculte de Medecine et de Pharmacie Laayoune, Maroc.
Published: August 2024

The isolated dislocation of the radial headisfrequentlydescribed in the lesion of MONTEGGIA. Howeveritcanbe a rare isolated pattern of injury in children. Only81 cases werereported in the literature to ourknowledge. The case we report concernsa 13 yearsold boy, examined 8 daysafterinjury. Because of failure of manualreduction, weperformed a surgical management withexcellent resultsafterayear of follow-up. We have discussedtreatment option and the resultsobtained.
ANESTHESIA DURING ATRIAL FIBRILLATION ABLATION : FIRST EXPERIENCE AND LITERATURE REVIEW
Authors:   Anesthesia Department and Resuscitation Unit Care of Cardiac Surgery and Cardiac Department, Ibn Sina Hospital, Rabat 10170., El Amraoui Wafae , Ettaje Ayoub ,   Anesthesia Department and Resuscitation Unit Care of Cardiacsurgery, Ibn Sina Hospital, Rabat 10170, Morocco., Bensouda Adil ,   Anesthesia Department and Resuscitation Unit Care of Cardiac Surgery, Ibn Sina Hospital, Rabat 10170, Morocco.
Published: August 2024

Background: General anesthesia is mostly performed for radiofrequency ablation for atrial fibrillation. Deep sedation is required for cryoablation. The ideal anesthetic protocol is unknown. We sought to report our anesthetic protocol used for the anesthesia of atrial fibrillation (AF) ablations as the first experience of our University Hospital over one year, with a literature review on anesthetic considerations to accompany AF ablations. Methods : anesthetic procedure begins with ergonomic layout of the cathlab. All patients who underwent AF ablation between January 2023 and January 2024 were identified prospectively in the cohort study. Our anesthetic protocol consists of midazolam and propofol as hypnotic agents and fentanyl for analgesia. Rocuronium is provided for general anesthesia. Intubation is required for general anesthesia. Patient is extubated once meeting standard criteria. Procedural complications are collected. Results: A total of 24 patients underwent AF ablation from January 2023 to January 2024. The average age was 60 years, with 62% women and 38% men (paroxysmal AF 51%, CHADS2VASC 1.17). The total duration of the procedures was between 2 and 2,5 hours. The median time to extubation was 25 minutes once the procedure was completed, with a total anesthesia time averaging 140 minutes. Three patients were recovered to general anesthesia. No other anesthesia-related complications were seen. Conclusion: Our anesthetic protocol is specifically designed for AF ablation. General anesthesia was safer than sedation, with no significant difference for efficient recovery and extubation times. Other protocols can be tested to avoid intubation. It is also necessary for anesthesiologists to optimize the space of cathlabs for safe use.
THE FACTORS CONTRIBUTE TO INCIDENCE TUBERCULOSIS AT IN PATIENT DEPARTMENT IN REFERRAL HOSPITAL OF BAUCAU, TIMOR-LESTE
Authors:   National University of Timor Loro Sae., Gregorio de Carvalho Joaquim , Pinto Joaquim ,   National University of Timor Loro Sae., Fernandes Belo Saturnina ,   National University of Timor Loro Sae., Oqui Maximiano ,   National University of Timor Loro Sae., C. Gaio Eduardo ,   National University of Timor Loro Sae., Cristina Fernandes Reci Sonia ,   National University of Timor Loro Sae.
Published: August 2024

Background: Tuberculosis (TB) is a communicable disease that not only causes illness health but also ranks among, one of the top 10 causes of death worldwide. In fact, it is and the leading cause of death from a single infectious agent (surpassing even HIV/AIDS). TB is caused by the bacillus Mycobacterium tuberculosis, which is spread through the air when individuals who are sick with TB expel bacteria for instance, by coughing. Globally, an estimated 10.0 (range, 8.9â€“11.0 million) people fell illness with TB in 2019, a number that has been declining very slowly in recent years. TB can affect to anyone and, the number of cases at the national level varies. In most countries, the majority of cases occur in 30 areas with highest incidence of TB were more than 90% of cases are reported. The global burden also includes an estimated 1.3 million peoples who are infected with TB and at risk of developing the disease. In Timor Leste, the recent WHO report on TB indicated a reduction in the incidence of TB in 2021 (WHO, TB Epidemiological Review 2023 Timor-Leste, 2023). The countrys incidence of TB has been 489 per 100.000 populations for the last few years. However, in 2021 there has been a decrease to 486 per 100.000 populations. Objective: The purpose of this study is to identify the factors that contribute the occurrence of Tuberculosis at the Referral Hospital of Baucau. Methodology: This descriptive study used both quantitative and quantitative methods together, specifically a cross-sectional study. Data were gathered using both methods concurrently. Quantitative data were analyzed using descriptive and analytic statistics with approach and spearman rank correlation coefficient as the statistical test The sampling technique that was employed the study was total sampling (50 sample). The data collected for of this study was primary data obtained gained from patients using a questionnaire as the instrument. Results: The results indicated 58% the incidence TB by environmental, 66% of nutritional and 52% by access health information. And also enviroment contribution to incidence TB was postive relationship because the result analysis showed value r=0,518. Its mean 51.8% of TB incidence caused by enviroment but 48,2% by another factors. Another factor likely nutrition status also mayority factor contribute incidence TB because value r=0,799. The hypothesis test indicated value significant fom enviroment and nutrition status showed 0.00. Conclusion: There was a significant value and positive contribution between the environment and nutritional status to incidence TB.
EFFECT OF QUALITY OF SLEEP ON GLYCEMIC CONTROL OF DIABETES MELLITUS PATIENTS IN ALMADINA ALMUNAWARA, SAUDI ARABIA
Authors:   Academic & Training Affairs, Madina, Institutions is Ministry of Health, KSA., M. Aljohani Riyadh , Aljohani Basim ,   Academic & Training Affairs, Institutions is Ministry of Health, Madina, KSA., M. Alshahrani Mana ,   Sleep Medicine Consultant, Riyadh, Institutions is Ministry of Health, KSA.
Published: August 2024

Insufficient and poor-quality sleep may raise the risk of chronic illnesses such as diabetes mellitus. The study aims to evaluate sleep disorders, their contributing factors, and their influence on glycemic control in diabetes patients (types I and II). A cross-sectional study was conducted at chronic disease clinics in primary healthcare centers and outpatient clinics at diabetic centers in Almadina Almunawara City, Saudi Arabia, amongpatients diagnosed with diabetes (type I and type II) and seen throughout the study period (September â€“ November 2022). A total of 302 diabetic patients were included. 31.8% of participants were between the ages of 51 and 60, whereas 26.5% exceeded 60 years. The result indicated that 63.9% of patients have poor sleep quality, according to PSQI. Multivariate logistic regression analysis demonstrated that patients having three or more are at a significantly higher risk of poor sleep quality compared to patients having no children (Adjusted odds ratio AOR =2.83 95% confidence interval CI = 1.22-6.55, p=0.015). Diabetic patients having family support in treating diabetes had a significantly lower incidence of poor sleep quality than those without family support (AOR=0.31, 95%CI=0.14-0.68, p=0.004). Patients with HbA1c%â‰¥7 were at a higher significant risk for poor sleep quality compared to those with HbA1c%<7 (AOR=1.88, 95% CI=1.03-3.44, p=0.041). In conclusion, sleep disorders are widespread among people with diabetes and have a detrimental influence on glycemic management.
ASSESSMENT OF NEWBORN PAIN RELATED TO CARE
Authors:   Department of Neonatology and Intensive Care Unit. Mohamed VI University Hospital of Oujda. Faculty of Medicine and Pharmacy of Oujda. University Mohamed First of Oujda., Bouhmidi Massilia , Messaoudi Sahar ,   Department of Neonatology and Intensive Care Unit. Mohamed VI University Hospital of Oujda. Faculty of Medicine and Pharmacy of Oujda. University Mohamed First of Oujda.,   Maternal Child and Mental Health Research Laboratory of Oujda, Oujda, MAR., Ayyad Anass ,   Department of Neonatology and Intensive Care Unit. Mohamed VI University Hospital of Oujda. Faculty of Medicine and Pharmacy of Oujda. University Mohamed First of Oujda.,   Maternal Child and Mental Health Research Laboratory of Oujda, Oujda, MAR., Amrani Rim ,   Department of Neonatology and Intensive Care Unit. Mohamed VI University Hospital of Oujda. Faculty of Medicine and Pharmacy of Oujda. University Mohamed First of Oujda.,   Maternal Child and Mental Health Research Laboratory of Oujda, Oujda, MAR.
Published: August 2024

Pain in newborns is an issue we cannot ignore any longer. The health care providers should confirm that the baby is comfortable during any procedures as it is not only that it is ethically right for them to treat in pain the patients but can also have serious after-effects in newborns and can also lead to other diseases. This study aimed to evaluate pain induced by medical procedures, describe pain management practices, and improve pain management. Two surveys were conducted: the first one on the patients through the prospective descriptive observational study. This was carried out in the NICU in the department of neonatology in the CHU MOHAMED VI of Oujda over a period of 4 months, starting from February 26, 2024 until June 26, 2024. Pain was assessed by using the DAN scale in 98 newborns (female: 56%, sex ratio: 1.27, premature: 42%, and mean weight: 2538g). The median DAN score duringmedical procedures was 4.5, which dropped to 1 three minutes after the painful procedure. The second survey was conducted among a sample of 45 medical and paramedical workers of the neonatology department of the CHU MOHAMED VI Oujda. Eighteen percent of the medical and paramedical staff indicated that they had taken specific training in pain and palliative care. A specific training session was organized for enhancing pain management. Before the training, 44% of caregivers had never assessed the pain level of their patient whereas after the training 78% of them will always assess the pain, this improved significantly post training. Regarding pain management, before training, it was not done routinely, fifty-eight percent of caregivers reported that they rarely or never used any preventive strategies, whereas after training, 84% reported always or often using preventive measures. The majority of caregivers were against the presence of parents during invasive procedures.
ROLE OF HYALURONIC ACID IN PERIODONTAL BONE REGENERATION
Authors: Priyanka S. , Sadasivan Arun , Koshi Elizabeth , Girija Vallabhan Chitra
Published: August 2024

Hyaluronic acid is a natural component of extra cellular matrix in both soft and hard periodontal tissues .Hyaluronic acid is located in both mineralised tissues (i.e cementum and alveolar bone) and non mineralised tissues (i.e gingiva and periodontal ligament) .Hyaluronic acid due to its anti-inflammatory ,anti -edematous ,anti- bacterial ,stimulation of angiogenic effects and osteoconductive effects has the potential to regulate periodontal tissue regeneration .Along with these properties , its role in modulation of wound healing makes it an adjunct to surgical and non surgical periodontal therapy.The use of Hyaluronic acid to treat periodontal bone defects has been shown to accelerate bone regeneration owing to its osteoconductive potential ,proliferation and differentiation of mesenchymal cells ,and regulating activities of osteoblast ,fibroblast ,cementoblast along with enhancement of osteogenetic effect of bone morphogenetic protein -2 in periodontal regeneration .This review examines the current literature favouring the use of hyaluronic acid in the regeneration of periodontal infrabony defects.
From Boomers to Millennials: unraveling the complexities of online shopping behavior in Indonesia
Authors: Rachbini Widarto , Y. Soeharso Silverius , Wulandjani Harimurti , Anwar Fathoni Muhammad , Rahmawati Emi
Published: August 2024

This study examines the intricate dynamics of utilitarian browsing, hedonic browsing, electronic word of mouth (e-WOM), e-satisfaction, and e-loyalty across three generational cohorts –Millennials, Gen X, and Baby Boomers – in Indonesian online marketplaces. The research addresses the need to understand how different age groups engage with online platforms amidst technological advancements and emerging generational cohorts. A quantitative approach is employed to systematically investigate these phenomena. Data from a structured online survey of 962 respondents are analyzed using descriptive statistics, ANOVA, and correlation analysis. The majority of respondents (50.5%) belong to the Millennial generation, followed by Generation X (31.2%) and Baby Boomers (16.2%).The findings reveal significant differences in utilitarian browsing (F = 11.222, p < 0.001), hedonic browsing (F = 6.338, p = 0.002), e-WOM (F = 3.488, p = 0.031), e-satisfaction (F = 6.239, p = 0.002), and e-loyalty (F = 9.298, p < 0.001) across different generational groups. Notably, Millennials and Gen X exhibit higher levels of utilitarian and hedonic browsing, e-satisfaction, and e-loyalty compared to Baby Boomers, while e-WOM engagement remains consistent across all cohorts. These findings provide valuable insights for businesses operating in the Indonesian online marketplace, guiding targeted marketing strategies, enhancing user experiences, and fostering customer loyalty. The research emphasizes the importance of aligning marketing approaches with the distinct preferences and behaviors of different generational segments. Furthermore, it suggests avenues for future research, including exploring additional demographic variables and conducting longitudinal studies to track evolving consumer dynamics.
El rawlsianismo y lo que urge
Authors: Camacho-Beltrán Enrique
Published: August 2024

En Justice as Fairness: A Restatement, Rawls afirmó que su concepción de la justicia debería servir de guía para una teoría no ideal de las injusticias del mundo real. No obstante, estableció al mismo tiempo un enigmático límite a su planteamiento, según el cual ni la filosofía política ni la justicia como equidad deben entenderse como enfoques aplicados. Como resultado, no queda claro cómo podría fungir como orientación contra las injusticias del mundo real, ya que presumiblemente se requeriría de conocimientos de ética aplicada. Este artículo se centra en esbozar una posible alternativa ofreciendo una reconstrucción parcialmente exhaustiva de lo razonable como virtud. La esperanza es utilizar la virtud de los ciudadanos razonables para transferir las reflexiones rawlsianas a un tipo especial de controversias de ética aplicada relacionadas con debates públicos urgentes y políticas de resistencia. La idea de esta construcción es permitir que la virtud de lo razonable establezca una norma para la conducta ciudadana.
Tradition and Critique in Kant and al-Jabri
Authors: Scaglia Lara
Published: August 2024

In this paper, I focus on Kant’s notion of God, showing that his critical philosophy changed the meaning and function of traditional concepts. Then I move on to consider a philosopher of the contemporary Arab world, al-Jabri, who has been influenced by Kant: the author of the Critique of Arab Reason shares with Kant a dissatisfaction regarding a certain use of reason which does not inquire about its boundaries. Philosophy must confront its tradition, free it from prejudices, search for reasons and investigate the origin and uses of its concepts, but critically analysing tradition does not imply that the past cannot help charting the path of the future. A fresh reading of tradition could help modernize Islam without losing the cultural elements of identity.
Múltiples universos, dimensionalidad del espacio y la posible hipergeometría: metafísica y cosmología en el primer Kant
Authors: Mendoza-Gurrola Paulo Sergio
Published: August 2024

En su primera obra, Kant discute la posibilidad de que exista más de un universo. Partiendo del principio de que las substancias tienen una fuerza esencial para actuar fuera de sí y de que ellas se vinculan solo en el ejercicio de esta fuerza, Kant concluye que la totalidad de las substancias vinculadas entre sí conforma un universo. Sin embargo, es perfectamente posible que una substancia exista sin estar vinculada con las substancias de un determinado universo, no formando parte de él, y que lo esté con otras substancias ajenas, conformando con ellas un universo aparte. Pero la posibilidad de múltiples universos requiere que haya espacios de distinta naturaleza o dimensionalidad para que tales universos se mantengan inconexos y sean realmente distintos universos y no partes distantes de un mismo universo. Esto sucede así porque la naturaleza del espacio depende específicamente de la fuerza con la que interactúan las substancias.
Development of Belarusian free economic zones: integration into the national economy and EAEU
Authors: Kireeva Elena F.
Published: August 2024

In the conditions of global economic and political turbulences, one of the most important aspects of economic development is the struggle for attracting investments. Changes in economic development models and humanitarian shocks affect the mechanisms of attracting capital. Free economic zones (FEZs) have a sufficiently large experience of functioning in the global economic system. FEZs acquire relatively new features in the ongoing economic processes, while regional economic integration has significant importance in terms of their functioning. The influence of integration processes on the FEZs’ development in the post-Soviet space has not been studied sufficiently, which the present research aims to solve. This article analyzes the features of the Belarusian FEZs forming and functioning in regional interaction within the Eurasian Economic Union (EAEU). Based on the Russian ad global world research, reports by international financial organizations, and legal acts regulating this sphere, the international economic integration is studied as the foundation for the FEZs’ development. The experience of the European Union (EU) as an integrative formation in regulating the functioning of national FEZs is studied. Special attention is paid to the main approaches to implementing state economic policy in relation to Belarusian FEZs. Additionally, the author analyzes their main economic indicators and identifies the problems of the current state. The results show the need to modernize FEZs considering integration aspects, presenting prospects for developing national FEZs and their functioning within the integrative interaction of the EAEU.
Prospects for improving the tools of the tax ecosystem in the context of systemic and technological transformations
Authors: Viktorova Natalia G. , Evstigneev Evgeniy N.
Published: August 2024

This article is a continuation of the author’s research on the formation and development of the tax ecosystem in the context of global systemic and technological transformations. It focuses on disclosing the toolkit of such a system, based on advanced information and telecommunications and other technologies, and allowing for a comprehensive solution to the problems of sustainable and balanced socio-economic development of the state. First of all, the article presents the content and structure of the hypothetical model of the tax ecosystem (GMNE), including the content and support parts. Further, a systematization of the support part of the ecosystem is carried out, considering it as a highly complex and hybrid system. The following ten groups of such support are identified: scientific and practical, personnel and educational, information and communication, technical and technological, political and legal, managerial and analytical, regulatory and supervisory, model and virtual, human-robotic, risk-oriented. The paper proposes the filling of each group with a toolkit. The problems of formation and improvement of tools for individual types of support are outlined. Conclusions and proposals are formulated. To identify the ten types of support for the hypothetical model of the tax ecosystem, methods of structural analysis and synthesis were used. Directions for further research can be associated with the actualization of both the structure of the supporting subsystem of the GMNE, as well as progressive tools for improving tax relations management in the Russian Federation, taking into account the uncertainty of the external environment caused by systemic and technological transformations.
Discurso del Ingeniero Forestal Ignacio Lombardi Indacochea en su nombramiento como Profesor Emérito de la Universidad Nacional Agraria La Molina
Authors: Lombardi Ignacio
Published: August 2024

The speech presents a summary of the activities carried out by the professor Ignacio Lombardi at the Universidad Nacional Agraria La Molina over more than 45 years in the institution, without considering the time as a student, where it is highlighted that he has held the positions of Vice-Rector for Teaching and Research, Dean of the Faculty of Forestry Sciences, among other academic and administrative positions. In addition to representing the University in different institutions, both national and foreign. Presents its own vision of institutional development and the commitments that must be made to the agrarian and fishing society of the country. Some challenges for development are pointed out that commit the university to professional training and research and extension, in order to respond to the demands of agricultural producers, especially medium and small producers, family farming and the development of natural forests and forest plantations.
Nanomaterials in Targeting Cancer Cells with Nanotherapeutics: Transitioning Towards Responsive Systems
Authors: Jain Bhawana , Verma Dakeshwar Kumar , Rawat Reena Negi , Berdimurodov Elyor
Published: August 2024

:

On a global scale, cancer is a difficult and devastating illness. Several problems with current chemotherapies
include cytotoxicity, lack of selectivity, stem-like cell growth, and multi-drug resistance. The
most appropriate nanomaterials for cancer treatment are those with characteristics, such as cytotoxicity, restricted
specificity, and drug capacity and bioavailability; these materials are nanosized (1-100 nm). Nanodrugs
are rarely licenced for therapeutic use despite growing research. These compounds need nanocarrier-targeted
drug delivery experiments to improve their translation. This review describes new nanomaterials reported
in the literature, impediments to their clinical studies, and their beneficial cancer therapeutic use. It also
suggests ways to use nanomaterials in cancer therapy more efficiently and describes the intrinsic challenges of
cancer treatment and the different nanocarriers and chemicals that can be utilised for specified tumour targeting.
Furthermore, it provides a concise overview of cancer theranostics methods, with a focus on those that
make use of nanomaterials. Although nanotechnology offers a great source for future advancements in cancer
detection and therapy, there is an emerging need for more studies to address the present barriers to clinical
translation.
Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer’s Disease
Authors: Hamdi Asma , Baroudi Sana , Gharbi Alya , Babay Wafa , Laaribi Ahmed Baligh , Kacem Imene , Mrabet Saloua , Zidi Ines , Klibi Naouel , Gouider Riadh , Ouzari Hadda-Imene
Published: August 2024

Background:

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder,
with a significant burden on global health. AD is characterized by a progressive cognitive decline
and memory loss. Emerging research suggests a potential link between periodontitis, specifically
the presence of oral bacteria such as Porphyromonas gingivalis (P. gingivalis), and AD progression.
P. gingivalis produces an enzyme, Agmatine deiminase (AgD), which converts agmatine
to N-carbamoyl putrescine (NCP), serving as a precursor to essential polyamines. Recent studies
have confirmed the correlation between disruptions in polyamine metabolism and cognitive impairment.

Objective:

This study aims to investigate the dysregulation of P. gingivalis Agmatine deiminase
(PgAgD) in the context of AD.

Methods:

Saliva samples were collected from a total of 54 individuals, including 27 AD patients
and 27 healthy controls. The expression of the PgAgD gene was analyzed using quantitative Real--
Time PCR.

Results:

The results showed a significant decrease in PgAgD gene expression in the saliva samples
of AD patients compared to healthy controls. This downregulation was found in AD patients
with advanced stages of periodontitis. Additionally, a correlation was observed between the decrease
in PgAgD expression and the 30-item Mini-Mental State Examination (MMSE) score.

Conclusion:

These findings suggest that measuring PgAgD expression in saliva could be a noninvasive
tool for monitoring AD progression and aid in the early diagnosis of patients with periodontitis.
Further research is needed to validate our results and explore the underlying mechanisms linking
periodontitis, PgAgD expression, and AD pathophysiology.
Circulating Exosomes Studied by Label-free Proteomics Analysis Reveal Transition Signatures from Diabetes Mellitus to Diabetic Kidney Disease
Authors: Yue Yue , Tao Yiying , Wang Jiaxin , Zhao Shidi , Zhao Fan , Shen Lei , Zhou Ling
Published: August 2024

Background:

Diabetic kidney disease (DKD) is a common microvascular complication
of diabetic mellitus (DM). At present, the early diagnosis of DKD mainly depends on microalbuminuria,
which is prone to be affected by confounding factors such as urinary tract infections.

Methods:

To identify the more stable early diagnosis markers, the whole proteome in the circulating
exosomes from controls, DM patients, and DKD patients was quantified by label-free proteomics
analysis and then validated with parallel reaction monitoring.

Results:

Three hundred ninety-one quantitative proteins were detected, and the expression trends
of 7 proteins in the validation phase were consistent with that in the discovery phase. The expression
level assessment results revealed that the expression of EFEMP1 and ApoA4 in the DKD
group was significantly higher than those in DM and controls. Correlation analysis showed that
EFEMP1 and APOA4 were positively correlated with urinary microalbumin and urinary albumin
creatinine ratio and had excellent diagnostic values for distinguishing DKD from DM and controls.

Conclusions:

ApoA4 and EFEMP1 could serve as the early diagnosis markers of DKD. These findings
provide a possibility for the development of a clinical diagnostic index that can efficiently
distinguish DKD from DM in the near future.