bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 10 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

ST_10 ATAC overlap ChIP
Supplementary Figure 2 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_2 Ancestry cell lines
Supplementary Figure 12 from African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A
Authors: Siddappa Manjunath , Hussain Shahid , Wani Sajad A. , White Jason , Tang Hancong , Gray Jaimie S. , Jafari Hedieh , Wu Hsu-Chang , Long Mark D. , Elhussin Isra , Karanam Balasubramanyam , Wang Honghe , Morgan Rebecca , Hardiman Gary , Adelani Isaacson B. , Rotimi Solomon O. , Murphy Adam R. , Nonn Larisa , Davis Melissa B. , Kittles Rick A. , Hughes Halbert Chanita , Sucheston-Campbell Lara E. , Yates Clayton , Campbell Moray J.
Published: April 2023

SF_12 BAZ1A-GSEA
Fostering reading interest through digital storytelling for young learners in the early childhood
Authors: Indriani Siane , Suteja Hanna
Published: April 2023

Children in the digital era are exposed to the advancement of information technology and multimedia that might bring both positive and negative influence toward their development. During early childhood, children are using mostly their senses to explore the world around them, including learning some values from the story books exposed to them. However, parents or family do not give optimal support in the children’s learning process. Therefore, it is a challenge for English language teaching (ELT) pre-service teachers in implementing a digital storytelling to engage the children with the learning material and creative ways to optimally utilize technology, but at the same time give a comprehensive support for children to improve their English skills as well as the embedded values within the stories. The present study aims to reveal the opportunities and challenges in fostering a child’s reading interest through digital storytelling. All the details were recorded through observations, responses from the children while they were watching the digital story, and a daily journal written by ELT pre-service teacher. From the result, it was found that through their interactions with the stories, children were exposed by the values embedded, furthermore, their reading interest is developing where more optimal support from the parents or caregivers is urgently needed.
Evaluation of recreation departments in theory and practice
Authors: Ergüven Ahmet Tarık
Published: April 2023

It is our source and it is irreversible. With industrialization, the time people spend at work has decreased, and their free time has increased. This has led people to look for new ways to spend their free time productively. At this point, graduates of the recreation department will have the opportunity to show the methods that will be useful for people to spend their free time efficiently in line with the education they receive. Since graduates are thought to be employed in organizations that provide leisure time services, the qualifications of graduates are important in this regard. In this study, the expectations of the employers from the graduates and the required qualifications of the graduates were investigated. One issue drawn from the results is that although each branch has specific expectations, all graduates must have certain qualifications, such as communication and constructive language skills.
Unveiling determinant of student engagement
Authors: Siregar Gustina , Bismala Lila , Hafsah Hafsah , Handayani Susi , Manurung Yayuk Hayulina , Andriany Dewi , Hasibuan Lailan Safina
Published: April 2023

The purpose of this study was to examine the moderating role of feedback in the influence between lecturer leadership, lecturer engagement, and student engagement. The study was conducted on students at the Universitas Muhammadiyah Sumatera Utara, Indonesia where the number of respondents who filled out the questionnaire was 231 respondents. With structural equation modeling, using SemPLS, a moderation test was conducted to prove the research hypothesis that had been designed. The results of the study show that although feedback affects student engagement, feedback does not act as a moderator in the influence between lecturer leadership, lecturer engagement, and student engagement. Meanwhile, lecturer engagement was found not to affect student engagement, but lecturer engagement significantly affected student engagement. In learning, lecturers must pay attention to feedback and lecturer leadership, if lecturers expect high student engagement. This has implications that lecturers have to provide feedback and practice lecturer leadership in the classroom.
The influence of professional attitude, welfare, self-sustaining development, and job satisfaction on teacher performance
Authors: Murwaningsih Tri , Fauziah Muna
Published: April 2023

This study aims to identify: i) The effect of teacher welfare, self-sustaining development, job satisfaction, and teacher performance on the teaching professional attitude; ii) The effect of teacher welfare on self-development, job satisfaction, and teacher performance; iii) The effect of self-sustaining development on the professional attitude, welfare, job satisfaction, and teacher performance of teachers; and iv) The effect of teacher job satisfaction on teaching performance. This study was quantitative research with a correlational type. The sample was 155 vocational high school teachers in Central Java, Indonesia. Data was collected through a questionnaire technique. The data analysis technique used structural equation modeling with the linear structural relationship type. The study revealed that the teacher's professional attitude has an effect on teacher welfare but not on self-development, job satisfaction, or teacher performance. Teacher welfare has an effect on independent development but has no effect on teacher performance. Hence, independent development does not affect job satisfaction but affects teacher performance. Furthermore, job satisfaction has no effect on teacher performance. These findings can be used as study material for future researchers to analyze the research variables or other variables, such as leadership style, work motivation, work discipline, and others.
Republicanismo inglês e a concepção neorromana de liberdade: a problemática interpretação de Quentin Skinner
Authors: Barros Alberto Ribeiro Gonçalves de
Published: April 2023

O objetivo do artigo é discutir a interpretação de Quentin Skinner no tocante à concepção de liberdade encontrada nos autores ingleses que defenderam o regime republicano estabelecido na Inglaterra entre 1649 e 1660. Em sua narrativa histórica, essa concepção de liberdade, caracterizada pela ausência de interferência arbitrária, seria inspirada na teoria romana dos Estados livres, expressa principalmente no pensamento republicano de Maquiavel, o que caracterizaria o republicanismo inglês como um momento maquiaveliano. A intenção é mostrar que essa narrativa é problemática: primeiro, porque não é possível extrair dos textos analisados de Maquiavel essa concepção de liberdade; depois, se esses autores ingleses utilizaram os argumentos de Maquiavel a favor do regime republicano, eles não acataram os seus principais fundamentos.
O igualitarianismo de Mary Wollstonecraft em A Vindication of the Rights of Men
Authors: Ostrensky Eunice
Published: April 2023

Em A Vindication of the Rights of Men, Mary Wollstonecraft elabora uma resposta a Reflections on the Revolution in France, de Edmund Burke, com base na oposição irredutível entre justiça e o estatuto da propriedade fundiária aristocrática. Entre os vários efeitos perniciosos da dominação dos proprietários sobre os não-proprietários, está a opressão das mulheres, legitimada pelo emprego da linguagem da sensibilidade. O artigo visa discutir a análise de Wollstonecraft sobre os fundamentos da sociedade aristocrática, lançando luz sobre seus valores morais.
Naming and Free Will
Authors: Merlussi Pedro , Lampert Fabio
Published: April 2023

Rigidity does interesting philosophical work, with important consequences felt throughout metaphysics, epistemology, philosophy of mind, and so on. The authors’ aim in this article is to show that rigidity has yet another role to play, with surprising consequences for the problem of free will and determinism, for the phenomenon of rigidity has the upshot that some metaphysically necessary truths are up to us. The significance of this claim is shown in the context of influential arguments against free will. The authors show that some virtually indisputable inference rules employed in formulations of the Consequence Argument, as well as in fatalistic arguments, fail with a variety of counter-examples. Along the way, the authors compare the present arguments to other, similar arguments made in recent years.
A Loosely Wittgensteinian Conception of the Linguistic Understanding of Large Language Models like BERT, GPT-3, and ChatGPT
Authors: Gubelmann Reto
Published: April 2023

In this article, I develop a loosely Wittgensteinian conception of what it takes for a being, including an AI system, to understand language, and I suggest that current state of the art systems are closer to fulfilling these requirements than one might think. Developing and defending this claim has both empirical and conceptual aspects. The conceptual aspects concern the criteria that are reasonably applied when judging whether some being understands language; the empirical aspects concern the question whether a given being fulfills these criteria. On the conceptual side, the article builds on Glock’s concept of intelligence, Taylor’s conception of intrinsic rightness as well as Wittgenstein’s rule-following considerations. On the empirical side, it is argued that current transformer-based NNLP models, such as BERT and GPT-3 come close to fulfilling these criteria.
Technologies and Sustainability – Challenges for Democracy and Education in Our Time
Authors: Neubert Stefan , Reich Kersten
Published: April 2023

In this essay, we discuss some urgent challenges for democracy and education in the Deweyan sense in connection with current developments of technologies and questions of sustainability. We proceed in four major parts, following the systematic distinction of four mutually interrelated levels of technologies in culture found in the late work of Michel Foucault. In part 1, we focus on the technologies of production. We connect Foucault’s perspective with more recent research on questions of social inequality and the production and distribution of wealth. In part 2, we address the level of technologies of sign systems, connecting Foucault’s perspective with critical approaches like Chomsky and Zuboff. In part 3, we turn to the level of technologies of power and domination. We use Crouch’s approach to post-democracy in order to examine some crucial dangers for democracy. In part 4, we look at the level of technologies of the self. We consider connections with contemporary constructivist as well as Deweyan perspectives in education that emphasize the role of relationships and processes of social self-creation. The essay closes with a summary of the most important conclusions of our discussion.
Ethics in the Innovation Process: Some Unaddressed Issues for Pragmatists
Authors: Thompson Paul B.
Published: April 2023

There are now dozens of proposals for integrating ethics into the early planning and assessment of technological innovation. This paper tracks some of Larry Hickman’s contributions to these trends. While Hickman’s suggestions could be incorporated into virtually many of the new proposals for integrating ethics into technological research, development and dissemination, barriers remain. In this paper, I will explores some reasons why the field remains fragmented, emphasizing weaknesses in the pragmatist approach. First, I acknowledge the significance of obvious explanations: the technical community’s unfamiliarity with ethical inquiry and the lack of both administrative and financial commitment to ethics-oriented research. There is, in short, an epistemic gap between the message that innovators are prepared to hear and the sophisticated response that Hickman’s pragmatism offers. This gap may be a practical limitation to philosophical pragmatism in many of its manifestations.
Education for Technological Threats to Democracy
Authors: Weber Eric Thomas
Published: April 2023

This paper examines Larry A. Hickman’s warnings about the dangers of algorithmic technologies for democracy and then considers educational policy initiatives that are important for combatting such threats over the long term. John Dewey’s philosophy is considered both in Hickman’s work and in this paper’s review of what Dewey called the “Supreme Intellectual Obligation.” Dewey’s insights highlight crucial tasks necessary and called for with respect to education to value and appreciate the sciences and what they can do to serve humanity. At the same time, a significant cultural effort is needed to ensure that schools are empowered to do this vital work and that the public is informed and enabled to demand the leadership and initiatives that democracy needs to safeguard against threats to it.
Association Between Body Tilt and Egocentric Estimates Near Upright
Authors: Tani Keisuke , Uehara Shintaro , Tanaka Satoshi
Published: April 2023

The mechanisms underlying geocentric (orientations of an object or the body relative to ‘gravity’) and egocentric estimates (object orientation relative to the ‘body’) have each been examined; however, little is known regarding the association between these estimates, especially when the body is nearly upright. To address this, we conducted two psychophysical experiments. In Experiment 1, participants estimated the direction of a visual line (subjective visual vertical; SVV) and their own body relative to gravity (subjective body tilt; SBT) and the direction of a visual line relative to the body longitudinal axis (subjective visual body axis; SVBA) during a small-range whole-body roll tilt. We evaluated the correlations between performance on each of these tasks as covariates of actual body tilt angles. Our results showed a significant correlation of performance (estimation errors) on the SVBA task with performance on the SBT task but not performance on the SVV task at the group level after adjusting for the actual body tilt angles, suggesting a link between the estimates for SVBA and SBT tasks. To confirm this relationship, in Experiment 2, we further assessed whether manipulating the subjective direction of the body axis by providing visual feedback in the SVBA task subsequently affected SBT performance. We found that feedback in the SVBA task significantly shifted the SBT angles even when the actual body angles were identical. The observed association between SVBA and SBT performance supports at least a partially shared mechanism underlying body tilt and egocentric estimates when the body is nearly upright.
The Transcendental Critique of Philosophical Thought and the Foundations of the Philosophical Community of Thought in the West
Authors: van Haeften Chris
Published: April 2023

Introduction to the translation of “De transcendentale critiek van het wijsgeerig denken en de grondslagen van de wijsgeerige denkgemeenschap van het avondland” by Herman Dooyeweerd (1941), Philosophia Reformata 6 (1), pp. 1–20.
Rohdea rotiformis (Asparagaceae), a new species from Northern Sichuan, China
Authors: FENG HUI ZHE , LIU MING , LI XUE YU , LIU XIAO , LIU LIN
Published: April 2023

Rohdea rotiformis is described and illustrated as a new species from Sichuan province of China. The new species possesses a cushionlike, ringed, fleshy appendage above the stamens in perianth throat. In these features, the new species is morphologically similar to R. urotepala but differs in its ringed appendage surface smooth without verruculose.
Strobilanthes sripadensis, a new species of Acanthaceae from Sri Lanka
Authors: NILANTHI RAJAPAKSE MUDIYANSELAGE RENUKA , GOPALLAWA BHATHIYA , JAYAWARDANA NUWAN , JAYASINGHE HIMESH DILRUWAN
Published: April 2023

Strobilanthes sripadensis, a new species of Acanthaceae from Peak Wilderness Nature Reserve, Sri Lanka is described and illustrated. Both morphological and palynological evidence clearly indicate that S. sripadensis is a distinct species. The new species is closely related to S. pentandra, but differs by having short acuminate leaf apex, entire or slightly sinuate leaf margin, 5–7 pairs of lateral veins, outermost bract longer than the inner one, bract, bracteole, and calyx pubescent, white corolla with prominent dark purple lines at throat and fertile stamens 4.The full description, line drawings, photographs, and information on habitat and ecology, distribution, phenology are also provided. It is accessed to be Critically Endangered according to the IUCN Red List categories and criteria.
Re-instatement of Craterostigma nanum (Linderniaceae) from the Pondoland Centre of Floristic Endemism and key to the South African species
Authors: GRIEVE KATHARINE W. , BESTER STOFFEL P.
Published: April 2023

There are currently only two species of Craterostigma recognised for South Africa, C. plantagineum and C. wilmsii. The present paper deals with the Craterostigma plants from the Pondoland Centre of Floristic Endemism along the eastern coast of South Africa. It is presently a synonym of C. plantagineum, an inland species of high elevations. However there are differences between C. plantagineum and the Pondoland plants, and a case is made for the re-instatement of C. nanum for the latter. An expanded description is provided, along with a proposed conservation assessment, and key to the species in South Africa.
Climate Response to Atlantic Meridional Energy Transport Variations
Authors: Jiang Weimin , Gastineau Guillaume , Codron Francis
Published: April 2023

The climate responses to Atlantic meridional overturning circulation (AMOC) fluctuations are investigated in a hierarchy of sensitivity experiments. We modify the baroclinic component of the North Atlantic Ocean currents online in an atmosphere–ocean general circulation model to reproduce typical AMOC multidecadal variability found in a preindustrial control simulation in the same model. An analogous experiment is also conducted using a slab-ocean experiment. The responses to a strong AMOC include a widespread warming in the Northern Hemisphere and a northward shift of the intertropical convergence zone over the Atlantic Ocean. The driving mechanism of climate responses is then investigated with the changes in the energy flows in the ocean and atmosphere. The large-scale atmospheric changes in the tropics are organized by an anomalous cross-equatorial Hadley circulation transporting energy southward and moisture and heat northward. Changes in the Indo-Pacific Ocean circulation and heat transport, driven by the wind stress associated with the abnormal Hadley cell, damp the atmospheric responses. The lack of Indo-Pacific transport and ocean heat storage leads to amplified atmospheric changes in the slab-ocean experiments, which are further amplified by a positive feedback due to the interhemispheric antisymmetric changes in low cloud cover.
Institutional change in higher music education: A quest for legitimacy
Authors: Ski-Berg Veronica , Røyseng Sigrid
Published: April 2023

Institutional change is being called for to renew higher music education (HME). But what institutional pressures, specifically, are driving these calls, and how are HME organisations responding to pressures to change? By turning to institutional theory, we lean on the concept of institutional isomorphism to shed light on how HME organisations may be navigating pressures to appear legitimate in the field to secure organisational survival. Drawing from a comparative case study of two HME organisations from Norway and the Netherlands, in which strategic plans and interview transcripts with students and professors have been analysed, we discuss how change processes are intertwined with an organisational quest for legitimacy. The findings suggest that there are overarching pressures to change in the field of HME and that variables in the institutional environment indicate how processes of change may unfold. Finally, implications of this unveiled landscape are discussed.
Multi-layered adaptive neoangiogenesis Intra-Operative quantification (MANIOQ)
Authors: Lacoin Guillaume , Zemmoura Ilyess , Gennisson Jean-Luc , Kouamé Denis , Remenieras Jean-Pierre
Published: April 2023

Quantification of vascularization volume can provide valuable information for diagnosis and prognosis in vascular pathologies. It can be adapted to inform the surgical management of gliomas, aggressive brain tumors characterized by exuberant sprouting of new blood vessels (neoangiogenesis). Filtered ultrafast Doppler data can provide two main parameters: vascularization index (VI) and fractional moving blood volume (FMBV) that clinically reflect tumor micro vascularization. Current protocols lack robust, automatic, and repeatable filtering methods. We present a filtrating method called Multi-layered Adaptive Neoangiogenesis Intra-Operative Quantification (MANIOQ). First, an adaptive clutter filtering is implemented, based on singular value decomposition (SVD) and hierarchical clustering. Second a method for noise equalization is applied, based on the subtraction of a weighted noise profile. Finally, an in vivo analysis of the periphery of the B-mode hyper signal area allows to measure the vascular infiltration extent of the brain tumors. Ninety ultrasound acquisitions were processed from 23 patients. Compared to reference methods in the literature, MANIOQ provides a more robust tissue filtering, and noise equalization allows for the first time to keep axial and lateral gain compensation (TGC and LGC). MANIOQ opens the way to an intra-operative clinical analysis of gliomas micro vascularization.
Migrant Care Workers’ Perceptions of Their Working Conditions in Australian Residential Aged Care Facilities
Authors: Adebayo Bola , Nichols Pam , Heslop Karen , Brijnath Bianca
Published: April 2023

Introduction:

Staff shortages and retention are the major challenges in residential aged care facilities (RACFs). This study aimed to explore migrant care workers’ perceptions of job demands, their coping strategies, and employment intentions to leave or stay in the sector.

Methods:

Using a descriptive qualitative research design, semi-structured interviews were conducted with n = 20, RACF migrant care workers from Filipino, Indian, and Nigerian backgrounds in Perth, Western Australia, from April to December 2019. Data were thematically analyzed.

Results:

Motivating factors included the availability of care work in RACFs, and positive cultural norms associated with caring for older family members. Participants experienced a combination of resettlement and workplace challenges specifically, limited support network, communication challenges, and racial discrimination.

Relevance to Practice:

Work challenges that are compounded by post-migration stressors should be recognized and addressed in the design and implementation of the aged care workforce reforms to attract and retain migrant care workers.
Food Safety Practice and Associated Factors of Food Handlers Working in Food Industries in Bahir Dar City, Amhara Regional State, Northwest Ethiopia, 2021
Authors: Alemu Mekuriaw , Motbianor Achenef , Birhanu Dereje , Birara Amsalu
Published: April 2023

Background:

Food safety has emerged as one of the 10 threats to global health. Ethiopia is among the developing countries with many food industries in recent times. Poor food handling procedures, a lack of basic infrastructure, lack of potable water, lack of financial resources to invest in safer equipment, and lack of training for food handlers have all been reported.

Objectives:

To assess food safety practices and associated factors among food handlers working in food industries in Bahir Dar city administrations.

Methods:

A cross-sectional study was conducted from January to February 2021 among 422 food handlers working in food industries in Bahir Dar city, Ethiopia. A random sampling technique was used to select food industries and study participants. The sample size was proportionately allocated to the selected food industries. Data were collected through face-to-face interviews and observation methods using interviewer-administered questionnaires and an observational checklist respectively. Data was entered into Epi-data v 3.1 and exported to SPSS v 23 for analysis. Bi-variable binary logistic regression was carried out to identify candidate variables at p-value <.2 and was entered into the final multivariable binary logistic regression model to control the effect of confounding. Variables with p-values of less than .05 were declared as statistically significant and an odds ratio of 95% CI was used to measure the strength of the association.

Result:

Food safety practice among food handlers working in food industries was 47.6% (95% CI: 42.8, 52.5). Sex [AOR: 2.92 (CI: 1.77, 4.82)], monthly salary [AOR: 2.02 (CI: 1.18, 3.44)], health supervision [AOR: 3.43 (CI: 1.97, 5.97)], working unit [AOR: 2.44, (CI: 1.45, 4.13], food safety training [AOR: 6.16 (2.97, 12.77)], attitude [AOR: 3.55 (CI: 1.14, 11.05)] were factors significantly associated with food safety practice.

Conclusion:

Food safety practice among food handlers was low. Sex, working unit, monthly income, regulatory supervision, food safety training, and attitude toward food safety were factors associated with poor food safety practices. In-service training on good hygiene practices, good manufacturing practices, hazard analysis, critical control point, food safety management systems, and supportive supervision should be strengthened.
Vatican Statement on Gender Theory in Education: Creating Competing Interests in Catholic Schools
Authors: Sellers Kathleen M.
Published: April 2023

In June 2019, the Vatican published its first-ever document on gender theory. This document was directed at Catholic educational institutions and draws on theology and philosophy, while excluding science on gender identity and testimonies from transgender people, to suggest gender theory is an ideology endangering the family. The case of Jane, a practicing Catholic and teacher–leader in a Catholic secondary school, contributing to cross-disciplinary curriculum development, school accreditation, and student mentorship, is used to anticipate problems of practice which may emerge as this document’s guidance is applied at the school level. Ecological systems theory and communities of practice theory are used to analyze this case.
SWOT analysis of a physical activity intervention delivered to outpatient adults with a mild traumatic brain injury
Authors: Alarie Christophe , Gagnon Isabelle , Thao Huynh Lily Trang , Doucet Karine , Pichette-Auray Adèle , Hinse-Joly Cassandre , Swaine Bonnie
Published: April 2023

Objectives:

Physical activity interventions are effective to reduce the symptoms and recovery time after a mild traumatic brain injury; such interventions are not always embedded in all interdisciplinary outpatient settings. Service providers of a specialized rehabilitation program recognized the need to implement emerging evidence-based approaches to improve physical activity delivery. Understanding the perceptions of managers, clinicians, and users regarding the strengths, weaknesses, opportunities, and threats of the current physical activity intervention delivered to outpatient adults with a mild traumatic brain injury could inform local and widespread intervention development, enhancement, and implementation of evidence-based physical activity interventions.

Methods:

This study used a descriptive qualitative design using a strength, weakness, opportunity, and threat analysis framework. Managerial staff ( n = 3), clinicians ( n = 6), and program users ( n = 5) with persisting symptoms following a mild traumatic brain injury from an outpatient specialized public rehabilitation program in Québec (Canada) participated. Individual semi-structured interviews were performed, recorded, transcribed verbatim, and analyzed using a qualitative content analysis approach.

Results:

Participants were generally positive about the intervention but expressed that improvement was required. Strengths ( n = 15), weaknesses ( n = 17), opportunities ( n = 12), and threats ( n = 6) related to eight overarching categories: physical activity intervention, health-related outcomes, clinical expertise, knowledge translation, communication, user engagement, resources, and accessibility. Category descriptions, convergent and divergent perspectives, and salient quotes of participants are provided.

Conclusions:

Participants were generally positive about the intervention (e.g., format) but identified weaknesses (e.g., need for service providers to better describe the physical activity intervention using theoretically driven approaches). Consultations of stakeholders will inform future intervention enhancement efforts and assist in ensuring interventions meet user needs.
Universal Mental Health Screening: Steps for School Counselors Through Multidisciplinary Teaming
Authors: Goodman-Scott Emily , Donohue Peg , Betters-Bubon Jennifer
Published: April 2023

School counselors collaborate with multidisciplinary teams to implement universal mental health screening (UMHS) in schools and this work is especially pertinent in light of the U.S. K–12 mental health crisis. Because the school counseling UMHS literature is still emerging, expanding this literature is necessary, particularly to meet students’ mental health concerns. The present study examined the qualitative experiences of school counselors and other multidisciplinary UMHS team members implementing screening. We coded data through a phenomenological lens and used deductive coding from the National Center for School Mental Health’s (2018) eight steps to UMHS. We discuss not only the results but applications and implications, geared toward school counselors at the building and district level to assist with their practice.
Community-Based Research in Fragile Contexts: Reflections From Rohingya Refugee Camps in Cox’s Bazar, Bangladesh
Authors: Hoque Mohammad Azizul , Ahmad Tasnuva , Manzur Samira , Prova Tasnia Khandaker
Published: April 2023

This commentary examines community-based research in fragile settings based on the authors’ experience working with Rohingya and host community researchers in Cox’s Bazar, Bangladesh. This iteration of a community-based approach to research focuses on putting community researchers at the center and emphasizes their involvement at each stage of the research process – from design to implementation to analysis – alongside external researchers. Community researchers contribute their expertise to increase understanding of nuances that might otherwise be lost to external researchers. Integral to this approach is building and nurturing the trust of researchers, respondents and community members through innovative means such as an informal “trust network.” Also central to the community-based approach, especially in fragile 1 settings, is a sustained emphasis on community researchers’ learning and skills-building. The commentary article describes methods developed by the Centre for Peace and Justice, Brac University (CPJ), implemented with Rohingya refugees and host community researchers in Cox’s Bazar. The article suggests:

Putting community members at the heart of learning and research approaches helps to amplify marginalized voices and emphasize their needs and choices. The political and economic atmosphere of a refugee setting can change rapidly. In such circumstances, community-based research can be vital to policymakers that seek to understand emerging concerns and issues. Community-based experiential education and research approaches hold potential to promote grassroots leadership among refugee youth in situations of protracted displacement. Strengthening the capacities of community researchers is crucial to this approach. Community researchers often lack language skills, especially writing and reading, and translating from local dialects to English or any other preferred language. The acquisition of research skills can also pave a durable and critical pathway toward meaningful youth engagement. Trust and familiarity between refugee interlocutors and researchers require long-term engagement. Creating a culture of mutual respect and dignity is of utmost importance. The community expects researchers to respect their religious beliefs and cultural values. The two-way exchange between community researchers and respondents enhances the learning process and can help discover areas for further inquiry.
Sintering inhibition and oil-absorption properties of calcined coal-series kaolin
Authors: Li Jiaquan , Huang Zhiwei , Wang Qian , Zhang Fengnian , Miao Yang , Gao Feng
Published: April 2023

In this study, aluminium fluoride trihydrate (AlF3⋅3H2O) was used to inhibit the sintering of calcined coal-series kaolin (CCSK). In addition, the oil absorption properties of CCSK were studied. The particle-size distribution, specific surface area and porosity of the samples were investigated as a function of calcination temperature and the addition of AlF3⋅3H2O. Moreover, the ability of AlF3⋅3H2O to improve the oil absorption of CCSK was explored. The morphology, structure and phase composition of the specimens were investigated using scanning electron microscopy and X-ray diffraction. The phase transition during heating of the samples was studied using thermogravimetric analysis. The preparation with 10 wt.% AlF3⋅3H2O had the optimal sintering inhibition effect on CCSK at 1000°C. The release of SiF4 gas during heating and the formation of mullite whiskers on the particle surface caused by AlF3⋅3H2O moderated the formation of molten-phase liquid bridges between particles and inhibited sintering of the raw material powder. Furthermore, the formation of submicron mullite whiskers on the surface of the CCSK particles enhanced the oil-absorption properties of the sample significantly.
PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
Authors: Mason Bianca N. , Hassler Shayne N. , DeFea Kathryn , Boitano Scott , Vagner Josef , Price Theodore J. , Dussor Greg
Published: April 2023

Background

Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache responses in preclinical models. It is also well known that vasodilators such as nitric oxide (NO) donors can trigger migraine attacks in migraine patients but not controls. In the current study we examined whether activation of PAR2 in the dura causes priming to the NO donor glyceryl trinitrate (GTN).

Methods

A preclinical behavioral model of migraine was used where stimuli (PAR2 agonists: 2at-LIGRL-NH2 (2AT) or neutrophil elastase (NE); and IL-6) were applied to the mouse dura through an injection made at the intersection of the lamdoidal and sagittal sutures on the skull. Following dural injection, periorbital von Frey thresholds and facial grimace responses were measured until their return to baseline. GTN was then given by intraperitoneal injection and periorbital hypersensitivity and facial grimace responses observed until they returned to baseline.

Results

We found that application of the selective PAR2 agonist 2at-LIGRL-NH2 (2AT) onto the dura causes headache-related behavioral responses in WT but not PAR2−/− mice with no differences between sexes. Additionally, dural PAR2 activation with 2AT caused priming to GTN (1 mg/kg) at 14 days after primary dural stimulation. PAR2−/− mice showed no priming to GTN. We also tested behavioral responses to the endogenous protease neutrophil elastase, which can cleave and activate PAR2. Dural neutrophil elastase caused both acute responses and priming to GTN in WT but not PAR2−/− mice. Finally, we show that dural IL-6 causes acute responses and priming to GTN that is identical in WT and PAR2−/− mice, indicating that IL-6 does not act through PAR2 in this model.

Conclusions

These results indicate that PAR2 activation in the meninges can cause acute headache behavioral responses and priming to an NO donor, and support further exploration of PAR2 as a novel therapeutic target for migraine.
Synergistic antibacterial effects of Ulva lactuca methanolic extract alone and in combination with different antibiotics on multidrug-resistant Klebsiella pneumoniae isolate
Authors: EL-Sayed Abeer I.M. , El-Sheekh Mostafa M. , Makhlof Mofida E.M.
Published: April 2023

Various antibiotics are available, including gentamicin, chloramphenicol, ampicillin, amoxicillin, and streptomycin, but they have some restrictions. Many microorganisms are resistant to these medications. A new antimicrobial source must be found or developed to solve this issue. Inhere, extract from seaweeds Ulva lactuca was investigated for its antibacterial activity using a well diffusion assay against Klebsiella pneumoniae, and a promising inhibition zone diameter was recorded to be 14.04 mm. The biochemical structure of the antibacterial compound was determined via GC-MS and FTIR analysis. Also, a micro-dilution assay was used to calculate the minimum concentration that makes inhibition (MIC) to be 1.25 mg/ml from U. extract reliable to prevent the visibility of any bacterial growth, this was followed by examining the antibacterial effect of U. Lactuca methanolic extract alone and the synergetic effect of U. Lactuca methanolic extract in combination with two different antibiotics (gentamicin and chloramphenicol). This was assayed by the agar well diffusion method to achieve promising and strong inhibiting power against K. pneumoniae. It was deduced that the maximum synergism could be achieved by adding 2.5 mg/ml of Ulva methanolic extract to gentamicin (4 µg/ml), and the results were illustrated obviously via transmission electron microscope in which severe morphological deteriorations were experienced by the treated cells. From this study, we can conclude that U. lactucae extract has the power to aid antibiotics in reducing the growth of pathogenic K. pneumoniae.
Transcriptome and metabolome analysis reveals key genes and secondary metabolites of Casuarina equisetifolia ssp. incana in response to drought stress
Authors: Zhang Shike , He Chunmei , Wei Long , Jian Shuguang , Liu Nan
Published: April 2023

Casuarina equisetifolia is drought tolerant, salt tolerant, and able to grow in barren environments. It is often used to reduce wind damage, to prevent sand erosion, and to help establish plant communities in tropical and subtropical coastal zones. To determine the basis for its drought tolerance, we conducted transcriptomic and metabolic analyses of young branchlets under a non-drought treatment (D_0h) and 2-, 12-, and 24-h-long drought treatments (D_2h, D_12h, and D_24h). A total of 5033 and 8159 differentially expressed genes (DEGs) were identified in D_2h/D_0h and D_24h/D_0h. These DEGs were involved in plant hormone signal transduction, jasmonic acid (JA) biosynthesis, flavonoid biosynthesis, and phenylpropanoid biosynthesis. A total of 148 and 168 differentially accumulated metabolites (DAMs) were identified in D_12h/D_0h and D_24h/D_0h, which were mainly amino acids, phenolic acids, and flavonoids. In conclusion, C. equisetifolia responds to drought by regulating plant hormone signal transduction and the biosynthesis of JA, flavonoid, and phenylpropanoid. These results increase the understanding of drought tolerance in C. equisetifolia at both transcriptional and metabolic levels and provide new insights into coastal vegetation reconstruction and management.
A retrospective study on the relationship between 5 modified frailty index (5-mFI) and postoperative complications of gynecological elderly patients undergoing abdominal surgery
Authors: Ma Hai-rui , Liu Jiang , Li Si-xun , Guo Xiao , Zhang Yun-feng , Lin Jing-yan
Published: April 2023

Introduction

Aim to evaluate the application of 5 modified frailty index (5-mFI) in predicting postoperative complications in elderly gynecological patients undergoing abdominal surgery.

Methods

A total of 294 elderly gynecological patients who were hospitalized in the affiliated Hospital of North Sichuan Medical College and underwent abdominal surgery from November 2019 to May 2022 were collected from the Union Digital Medical Record (UniDMR) Browser of the hospital. According to whether postoperative complications (infection, hypokalemia, hypoproteinemia, poor wound healing and intestinal obstruction) occurred, the patients were divided into complication group (n = 98) and non-complication group (n = 196). Univariate and multivariate logistic regression analysis were used to analyze the risk factors of complications in elderly gynecological patients undergoing abdominal surgery. The receiver operating characteristic (ROC) curve was used to determine the predictive value of the frailty index score in elderly gynecological patients with postoperative complications after abdominal surgery.

Results

Postoperative complications occurred in 98 of 294 elderly gynecological patients undergoing abdominal surgery, accounting for 33.3%, 5-mFI (OR1.63, 95%CI 1.07–2.46,P = 0.022), age (OR1.08,95%CI 1.02–1.15, P = 0.009), operation time (OR 1.01, 95%CI 1.00-1.01). P < 0.001) were independent risk factors for postoperative complications in elderly patients undergoing abdominal surgery, and the area under the curve of postoperative complications in elderly gynecological patients was 0.60. (95%CI: 0.53–0.67, P = 0.005)

Conclusion

Five modified frailty index can effectively predict the occurrence of postoperative complications in elderly gynecological patients.
Undiagnosed sub-valvular aortic stenosis with an associated Ventricular Septal Defect (VSD) presenting late in a multi-parous woman
Authors: Appiah Lambert Tetteh , Gyabaah Solomon , Adu-Boakye Yaw , Nkum Bernard C.
Published: April 2023

Background

Sub-valvular aortic stenosis is a rare disorder that has a prevalence of 6.5% of all adult congenital heart diseases. The hemodynamic changes that occur in pregnancy with the resultant increase in cardiac output may not well be tolerated by a pregnant woman with sub-valvular aortic stenosis.

Case presentation

We report the case of a 34-year-old para 7 (6 alive + 1 dead) who has been experiencing intermittent episodes of easy fatigability on moderate exertion since childhood and had survived 6 prior pregnancies. During her last pregnancy, she started experiencing chest pain, palpitations, dyspnea, orthopnea, and pre-syncope at 36 weeks and had a caesarean section at 37 weeks on account of fetal distress. The post-delivery cardiac evaluation showed severe sub-valvular Aortic stenosis and a ventricular septal defect.

Conclusion

Sub-valvular Aortic stenosis may progress slowly in adults and may be tolerated during pregnancy. Despite the rare presentation and contraindication of pregnancy in such a patient, she extraordinarily survived the pregnancy with a healthy baby. Routine cardiovascular assessment during prenatal, ante-natal and post-natal care is highly advocated particularly so in resource-poor settings.
Zoster Sine Herpete: two unusual cases of varicella-zoster reactivation with atypical complaints of acute chest pain and severe headache
Authors: Yang Yilin , Mahmood Talha , Siddiqui Afsheen H. , Aziz Muhammad A.
Published: April 2023

In this case report, we describe two unusual presentations of varicella-zoster virus (VZV) reactivation without rash, a condition known as Zoster Sine Herpete (ZSH). In Case 1, a 58-year-old woman presented with severe right-sided chest pain under her breast that radiated to the ipsilateral back. After the initial workup ruled out cardiac and musculoskeletal etiologies, the characteristic dermatomal distribution of pain made us suspect VZV reactivation. A diagnosis of ZSH was made with positive VZV IgG and IgM serologies and symptomatic relief after famciclovir treatment. In Case 2, a 43-year-old woman presented with a severe headache and resolved sharp right flank pain. She was diagnosed with varicella meningitis after cerebrospinal fluid showed positive VZV DNA. Intravenous acyclovir treatment resulted in symptom resolution. The most common presentation of VZV reactivation is Herpes Zoster, or shingles, making ZSH a frequently missed diagnosis. High clinical suspicion is warranted to prevent life-threatening complications of ZSH.
Evaluation of the interaction between tumor growth factor-β and interferon type I pathways in patients with COVID-19: focusing on ages 1 to 90 years
Authors: Abbasifard Mitra , Fakhrabadi Ali Hasani , Bahremand Fatemeh , Khorramdelazad Hossein
Published: April 2023

Background

Evidence revealed that age could affect immune responses in patients with the acute respiratory syndrome of coronavirus 2 (SARS-CoV-2) infection. This study investigated the impact of age on immune responses, especially on the interaction between the tumor growth factor-β (TGF-β) and interferon type-I (IFN-I) axes in the pathogenesis of novel coronavirus disease 2019 (COVID-19).

Methods

This age-matched case–control investigation enrolled 41 COVID-19 patients and 40 healthy controls categorized into four groups, including group 1 (up to 20 years), group 2 (20–40 years), group 3 (40–60 years), and group 4 (over 60 years). Blood samples were collected at the time of admission. The expression of TGF-βRI, TGF-βRII, IFNARI, IFNARII, interferon regulatory factor 9 (IRF9), and SMAD family member 3 (SMAD3) was measured using the real-time PCR technique. In addition, serum levels of TGF-β, IFN-α, and SERPINE1 were measured by the enzyme-linked immunosorbent assay (ELISA) technique. All biomarkers were measured and analyzed in the four age studies groups.

Results

The expression of TGF-βRI, TGF-βRII, IFNARI, IFNARII, IRF9, and SMAD3 was markedly upregulated in all age groups of patients compared with the matched control groups. Serum levels of IFN-α and SERPINE1 were significantly higher in patient groups than in control groups. While TGF-β serum levels were only significantly elevated in the 20 to 40 and over 60 years patient group than in matched control groups.

Conclusions

These data showed that the age of patients, at least at the time of admission, may not significantly affect TGF-β- and IFN-I-associated immune responses. However, it is possible that the severity of the disease affects these pathway-mediated responses, and more studies with a larger sample size are needed to verify it.