bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of fish catch potential using assimilation of synthetic measurements with an individual-based model
Authors: Kelly Cian , Michelsen Finn Are , Alver Morten Omholt
Published: November 2023

A large fraction of costs in wild fisheries are fuel related, and while much of the costs are related to gear used and stock targeted, search for fishing grounds also contributes to fuel costs. Lack of knowledge on the spatial abundance of stocks during the fishing season is a limiting factor for fishing vessels when searching for suitable fishing grounds, and with better planning and routing, costs can be reduced. Strategic and tactical decision-making can be improved through operational decision support tools informed by real-time data and knowledge generated from research. In this article, we present a model-based estimation approach for predicting catch potential of ocean areas. An individual-based model of herring migrations is combined with an estimation approach known as Data Assimilation, which corrects model states using incoming data sources. The data used to correct the model are synthetic measurements generated from neural network output. Input to the neural network was vessel activity data of over 100 fishing vessels from 2015-2018, targeting mainly herring. The output is the predicted normalized density of herring in discrete grid cells. Model predictions are improved through assimilation of synthetic measurements with model states. Characterizing patterns from model output provides novel information on catch potential which can inform fishing activity.
Lumpy skin disease: history, current understanding and research gaps in the context of recent geographic expansion
Authors: Mazloum Ali , Van Schalkwyk Antoinette , Babiuk Shawn , Venter Estelle , Wallace David B. , Sprygin Alexander
Published: November 2023

Lumpy skin disease is recognized as a transboundary and emerging disease of cattle, buffaloes and other wild ruminants. Being initially restricted to Africa, and since 1989 the Middle East, the unprecedented recent spread across Eurasia demonstrates how underestimated and neglected this disease is. The initial identification of the causative agent of LSD as a poxvirus called LSD virus, was well as findings on LSDV transmission and epidemiology were pioneered at Onderstepoort, South Africa, from as early as the 1940s by researchers such as Weiss, Haig and Alexander. As more data emerges from an ever-increasing number of epidemiological studies, previously emphasized research gaps are being revisited and discussed. The currently available knowledge is in agreement with the previously described South African research experience that LSDV transmission can occur by multiple routes, including indirect contact, shared water sources and arthropods. The virus population is prone to molecular evolution, generating novel phylogenetically distinct variants resulting from a diverse range of selective pressures, including recombination between field and homologous vaccine strains in cell culture that produce virulent recombinants which pose diagnostic challenges. Host restriction is not limited to livestock, with certain wild ruminants being susceptible, with unknown consequences for the epidemiology of the disease.
Neocortical and cerebellar malformations affect flurothyl-induced seizures in female C57BL/6J mice
Authors: Keever Katherine M. , Li Ying , Womble Paige D. , Sullens D. Gregory , Otazu Gonzalo H. , Lugo Joaquin N. , Ramos Raddy L.
Published: November 2023

Brain malformations cause cognitive disability and seizures in both human and animal models. Highly laminated structures such as the neocortex and cerebellum are vulnerable to malformation, affecting lamination and neuronal connectivity as well as causing heterotopia. The objective of the present study was to determine if sporadic neocortical and/or cerebellar malformations in C57BL/6J mice are correlated with reduced seizure threshold. The inhaled chemi-convulsant flurothyl was used to induce generalized, tonic-clonic seizures in male and female C57BL/6J mice, and the time to seizure onset was recorded as a functional correlate of brain excitability changes. Following seizures, mice were euthanized, and brains were extracted for histology. Cryosections of the neocortex and cerebellar vermis were stained and examined for the presence of molecular layer heterotopia as previously described in C57BL/6J mice. Over 60% of mice had neocortical and/or cerebellar heterotopia. No sex differences were observed in the prevalence of malformations. Significantly reduced seizure onset time was observed dependent on sex and the type of malformation present. These results raise important questions regarding the presence of malformations in C57BL/6J mice used in the study of brain development, epilepsy, and many other diseases of the nervous system.
Discovery of potent STAT3 inhibitors using structure-based virtual screening, molecular dynamic simulation, and biological evaluation
Authors: Liu Weifeng , Chu Zhijie , Yang Cheng , Yang Tianbao , Yang Yanhui , Wu Haigang , Sun Junjun
Published: November 2023

Introduction

Signal transducer and activator of transcription 3 (STAT3) is ubiquitously hyper-activated in numerous cancers, rendering it an appealing target for therapeutic intervention.

Methods and results

In this study, using structure-based virtual screening complemented by molecular dynamics simulations, we identified ten potential STAT3 inhibitors. The simulations pinpointed compounds 8, 9, and 10 as forming distinct hydrogen bonds with the SH2 domain of STAT3. In vitro cytotoxicity assays highlighted compound 4 as a potent inhibitor of gastric cancer cell proliferation across MGC803, KATO III, and NCI-N87 cell lines. Further cellular assays substantiated the ability of compound 4 to attenuate IL-6-mediated STAT3 phosphorylation at Tyr475. Additionally, oxygen consumption rate assays corroborated compound 4's deleterious effects on mitochondrial function.

Discussion

Collectively, our findings position compound 4 as a promising lead candidate warranting further exploration in the development of anti-gastric cancer therapeutics.
Virtual reality hypnosis diminishes experimental cold pain and alters autonomic responses
Authors: Terzulli Claire , Chauvin Chloé , Champagnol Di-Liberti Cédric , Faisan Sylvain , Goffin Laurent , Gianesini Coralie , Graff Denis , Dufour André , Laroche Edouard , Salvat Eric , Poisbeau Pierrick
Published: November 2023

Immersive virtual reality (VR) is a promising tool to reduce pain in clinical setting. Digital scripts displayed by VR disposals can be enriched by several analgesic interventions, which are widely used to reduce pain. One of these techniques is hypnosis induced through the VR script (VRH) which is facilitated by immersive environment and particularly efficient even for low hypnotizable patients. The aim of this study is to assess the efficacy of a VRH script on experimentally induced cold pain perception (intensity and unpleasantness) and physiological expression. 41 healthy volunteers had been recruited in this within-subjects study. They received 9 stimulations of 20 s (3 non-nociceptive cold; 3 low nociceptive cold and 3 highly nociceptive cold) during a VRH session of 20 min (VRH condition) or without VRH (noVRH condition). Physiological monitoring during the cold pain stimulation protocol consisted of recording heart rate, heart rate variability and respiratory frequency. Maximum cold pain intensity perception, measured through the visual analog scale (VAS) on 10, was of 3.66 ± 1.84 (VAS score/10) in noVRH condition and 2.46 ± 1.54 in VRH (Wilcoxon, p < 0.0001). Considering pain unpleasantness perception, 3.68 ± 2.06 in noVRH and 2.21 ± 1.63 in VRH (Wilcoxon, p < 0.0001). Hypnotizability negatively correlated with the decrease in VAS intensity from noVRH to VRH (Spearman r = −0.45; p = 0.0038). In our sample, we found that 31/41 volunteers (75.6%) displayed a reduction of more than 10% of their VAS pain intensity and unpleasantness scores. Trait anxiety was the best predictor of the VRH responders, as well as heart rate variability. In addition, respiratory rate was diminished under VRH in every subgroup. VRH is an effective tool to reduced pain intensity and unpleasantness in a vast majority of healthy subjects. We further indicate in this study that heart rate variability parameter RMSSD (root mean square of successive differences) is a good predictor of this effect, as well as anxiety as a personality trait (but not state anxiety). Further studies are expected to determine more precisely to whom it will be the most useful to offer tailored, non-pharmacological pain management solutions to patients.
Survival nomogram for medulloblastoma and multi-center external validation cohort
Authors: Li Xiang , Gong Jian
Published: November 2023

Background: Medulloblastoma (MB) is a highly malignant neuroepithelial tumor occurring in the central nervous system. The objective of this study was to establish an effective prognostic nomogram to predict the overall survival (OS) of MB patients.

Materials and methods: The nomogram was developed using data from a retrospective cohort of 280 medulloblastoma patients (aged 3–18 years) identified from Beijing Tiantan Hospital between 2016 and 2021 as the training cohort. To validate the performance of the nomogram, collaborations were formed with eight leading pediatric oncology centers across different regions of China. A total of 162 medulloblastoma patients meeting the inclusion criteria were enrolled from these collaborating centers. Cox regression analysis, best subsets regression, and Lasso regression were employed to select independent prognostic factors. The nomogram’s prognostic effectiveness for overall survival was assessed using the concordance index, receiver operating characteristic curve, and calibration curve.

Results: In the training cohort, the selected variables through COX regression, best subsets regression, and Lasso regression, along with their clinical significance, included age, molecular subtype, histological type, radiotherapy, chemotherapy, metastasis, and hydrocephalus. The internally and externally validated C-indexes were 0.907 and 0.793, respectively. Calibration curves demonstrated the precise prediction of 1-, 3-, and 5-year OS for MB patients using the nomogram.

Conclusion: This study developed a nomogram that incorporates clinical and molecular factors to predict OS prognosis in medulloblastoma patients. The nomogram exhibited improved predictive accuracy compared to previous studies and demonstrated good performance in the external validation cohort. By considering multiple factors, clinicians can utilize this nomogram as a valuable tool for individualized prognosis prediction and treatment decision-making in medulloblastoma patients.
Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model
Authors: Bao Xueying , Zheng Zhuangzhuang , Lv Jincai , Bao Jindian , Chang Sitong , Jiang Xin , Xin Ying
Published: November 2023

Numerous studies have shown that neuroinflammation is involved in the process of neuronal damage in neurodegenerative diseases such as Parkinson’s disease (PD), for example, and that inhibiting neuroinflammation help improve PD. Shikimic acid (SA) has anti-inflammatory, analgesic and antioxidant activities in numerous diseases. However, its effect and mechanism in PD remain unclear. In this experiment, we found that SA inhibits production of pro-inflammatory mediators and ROS in LPS-induced BV2 cells. Mechanistic studies demonstrated that SA suppresses neuro-inflammation by activating the AKT/Nrf2 pathway and inhibiting the NF-κB pathway. Further in vivo study, we confirmed that SA ameliorated the neurological damage and behavioral deficits caused by LPS injection in mice. In summary, these study highlighted the beneficial role of SA as a novel therapy with potential PD drug by targeting neuro-inflammation.
Interplay between improved interaction rates and modified cosmological histories for dark matter
Authors: Biondini Simone
Published: November 2023

A novel particle has been and still is an intriguing option to explain the strong evidence for dark matter in our universe. To quantitatively predict the dark matter energy density, two main ingredients are needed: interaction rates and the history of expansion of the universe. In this work, we explore the interplay between the recent progress in the determination of particle production rates and modified cosmological histories. For the freeze-out mechanism, we focus on Sommerfeld and bound-state effects, which boost and make dark matter pair annihilation more efficient. As regards the freeze-in option, we include thermal masses, which enter the decay processes that produce dark matter, and we find that they can suppress or enhance the dark matter yield. We consider a class of modified cosmological histories that induce a faster universe expansion, and we assess their effect in combination with improved particle interaction rates on the dark matter energy density.
Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex
Authors: Grotle A. K. , Langlo J. V. , Holsbrekken E. , Stone A. J. , Tanaka H. , Fadel P. J.
Published: November 2023

Autonomic adjustments of the cardiovascular system are critical for initiating and sustaining exercise by facilitating the redistribution of blood flow and oxygen delivery to meet the metabolic demands of the active skeletal muscle. Afferent feedback from active skeletal muscles evokes reflex increases in sympathetic nerve activity and blood pressure (BP) (i.e., exercise pressor reflex) and contributes importantly to these primary neurovascular adjustments to exercise. When altered, this reflex contributes significantly to the exaggerated sympathetic and BP response to exercise observed in many cardiovascular-related diseases, highlighting the importance of examining the reflex and its underlying mechanism(s). A leading risk factor for the pathogenesis of cardiovascular disease in both males and females is aging. Although regular exercise is an effective strategy for mitigating the health burden of aging, older adults face a greater risk of experiencing an exaggerated cardiovascular response to exercise. However, the role of aging in mediating the exercise pressor reflex remains highly controversial, as conflicting findings have been reported. This review aims to provide a brief overview of the current understanding of the influence of aging on cardiovascular responses to exercise, focusing on the role of the exercise pressor reflex and proposing future directions for research. We reason that this review will serve as a resource for health professionals and researchers to stimulate a renewed interest in this critical area.
Knockout of OsWRKY71 impairs Bph15-mediated resistance against brown planthopper in rice
Authors: Li Xiaozun , Zhang Jian , Shangguan Xinxin , Yin Jingjing , Zhu Lili , Hu Jie , Du Bo , Lv Wentang
Published: November 2023

The Bph15 gene, known for its ability to confer resistance to the brown planthopper (BPH; Nilaparvata lugens Stål), has been extensively employed in rice breeding. However, the molecular mechanism by which Bph15 provides resistance against BPH in rice remains poorly understood. In this study, we reported that the transcription factor OsWRKY71 was highly responsive to BPH infestation and exhibited early-induced expression in Bph15-NIL (near-isogenic line) plants, and OsWRKY71 was localized in the nucleus of rice protoplasts. The knockout of OsWRKY71 in the Bph15-NIL background by CRISPR-Cas9 technology resulted in an impaired Bph15-mediated resistance against BPH. Transcriptome analysis revealed that the transcript profiles responsive to BPH differed between the wrky71 mutant and Bph15-NIL, and the knockout of OsWRKY71 altered the expression of defense genes. Subsequent quantitative RT-PCR analysis identified three genes, namely sesquiterpene synthase OsSTPS2, EXO70 family gene OsEXO70J1, and disease resistance gene RGA2, which might participate in BPH resistance conferred by OsWRKY71 in Bph15-NIL plants. Our investigation demonstrated the pivotal involvement of OsWRKY71 in Bph15-mediated resistance and provided new insights into the rice defense mechanisms against BPH.
Retrospective study of tetanus in 18 dogs—Causes, management, complications, and immunological status
Authors: Dörfelt Stefanie , Mayer Christine , Wolf Georg , Straubinger Reinhard K. , Fischer Andrea , Hartmann Katrin , Dörfelt Rene
Published: November 2023

Objective

Tetanus is a severe neurologic disease caused byClostridium tetani, resulting in spastic paralysis. Canine tetanus is associated with serious complications such as aspiration and a high mortality rate of up to 50%.

Materials and methods

Medical records of all dogs diagnosed with tetanus over 8 years (2014–2022) were analyzed for severity grade, treatment protocols, nutritional management, and complications, as well as outcome, vaccination, and antibody production in some dogs. No medical records were excluded. Normality was analyzed by the D'Agostino–Pearson test. Parametric, normally distributed data were presented as mean ± standard deviation. Non-parametric, non-normally distributed data were presented as median (m) and range (minimum–maximum). The association between tetanus grade, progression of diseases, and duration of hospitalization was analyzed using thet-test, Mann–Whitney U test, and Kruskal–Wallis test. AP≤ 0.05 was considered significant.

Results

Eighteen dogs were identified. Most affected dogs were classified into severity grade II (66.7%, 12 of 18). Clinical signs deteriorated in 55.6% of dogs (10 of 18). A source was identified in 88.9% of dogs (16 of 18). Nine dogs required surgical wound revision. A percutaneous endoscopic gastropexy tube was placed in 83.3% of dogs (15 of 18) for nutritional support. Medical treatment included metronidazole, methocarbamol, and combinations of different sedatives adapted to the patient's requirements. Tetanus antitoxin was used in 72.2% of dogs (13 of 18) without reported adverse events. The survival rate was 88.9% (16 of 18). Complications, such as hypertension, aspiration pneumonia, and laryngeal spasm occurred in 12 of 18 dogs. Median hospitalization time (8 days; range 0–16 days) was associated with the maximum tetanus severity grade (p = 0.022). Rapid eye movement behavior disorder was observed in 72.2% of dogs (13 of 18). In 5 dogs, antibodies were measured after recovery, and in 4 of 5 dogs, no antibodies were detectable despite generalized tetanus disease. Vaccination with tetanus toxoid was performed in five dogs following the disease.

Conclusion

In the present study, the mortality rate was lower than previously reported. Tetanus is still a life-threatening disease, but the prognosis may be good if adequate management and monitoring can be ensured.
Aircraft Wing Design for Extended Hybrid Laminar Flow Control
Authors: Lobitz Lennart , Traub Hendrik , Overbeck Mats , Bień Maximilian , Heimbs Sebastian , Hühne Christian , Friedrichs Jens , Horst Peter
Published: November 2023

Laminar flow offers significant potential for increasing the energy-efficiency of future transport aircraft. The German Cluster of Excellence SE2A is developing a new approach for hybrid laminar flow control. The concept aims to maintain laminar flow up to 80% of the chord length by integrating suction panels at the rear part of the wing, which consist of a thin suction skin and a supporting core structure. This study examines effects of various suction panel configurations on wing mass and load transfer for an all-electric short-range aircraft. Suction panel material, as well as thickness and relative density of the suction panel core are modified in meaningful boundaries. Suction panels made from Ti6Al4V offer the most robust design resulting in a significant increase in wing mass. For the studied configurations, they represent up to 33.8% of the mass of the wingbox. In contrast, panels made from Nylon11CF or PU1000 do not significantly increase the wing mass. However, the use of these materials raises questions about their robustness under operational conditions. The results demonstrate that the choice of material strongly influences the load path within the wing structure. Ti6Al4V suction panels provide sufficient mechanical properties to significantly contribute to load transfer and buckling stiffness. Locally, the share of load transfer attributed to the suction panel exceeds 50%. In contrast, compliant materials such as Nylon11CF or PU1000 are inherently decoupled from load transfer. Unlike the thickness of the suction skin, the relative density of the core structure strongly affects the wrinkling stiffness. However, wrinkling failure did not appear critical for the examined suction panel configurations. In the present study, the mechanical properties of Ti6Al4V cannot fully be exploited. Therefore, compliant suction panels made from Nylon11CF are preferred in order to achieve a lightweight solution, provided that they meet operational requirements.
The Effects of Thermal and Pulsed Electric Field Processing on the Physicochemical and Microbial Properties of a High-Fiber, Nutritious Beverage from a Milk-Based Date Powder
Authors: Younis Mahmoud , Mohamed Ahmed Isam A. , Ahmed Khaled A. , Yehia Hany M. , Abdelkarim Diaeldin O. , Alhamdan Abdulla , Elfeky Ahmed
Published: November 2023

The effects of pulsed electric field treatment and thermal pasteurization on the microbial and physical properties of a high-fiber, nutritional milk-based beverage made with date powder were studied. Four ratios of date powder (10, 15, 20, and 25 w/w) were added to the milk, which was then kept at 5 °C for 6 days for the thermal pasteurization and the control treatments. The pulsed electric field treatment had three levels of pulses (20, 50, and 80 pulses) and four ratios of date powder, 10, 15, 20, and 25% (w/w), and then kept at 5 °C for 6 days. The samples were evaluated for the pH, total soluble solids (TSS), total color difference (ΔE), and total viable count (TVC) during their shelf life. The pH values of the beverages in the control treatment were 5.58, 5.45, 5.33, and 5.29 and 6.68, 6.48, 6.26, and 5.87 in the thermal treatment after 6 days, with powder ratios of 10, 15, 20, and 25% (w/w), respectively. The pH values of the beverages in the pulsed electric field treatment were 6.8, 6.64, 6.56, and 6.28 at 80 pulses after 6 days, with powder ratios of 10, 15, 20, and 25% (w/w), respectively. The TVCs in the control treatment were 6.2, 5.44, 4.5, and 3.94 log10 CFU/mL and 4.02, 3.92, 3.54, and 3.31 log10 CFU/mL in the thermal treatment after 6 days, with powder ratios of 10, 15, 20, and 25% (w/w), respectively. The TVCs of the beverages in the pulsed electric field treatment were 1.53, 1.11, 0.665, and 0.511 log10 CFU/mL at 80 pulses after 6 days, with powder ratios of 10, 15, 20, and 25% (w/w), respectively. This shows that following treatment with a pulsed electric field at 80 pulses, a milk-based drink with date powder and no preservatives can be kept at 5 °C for up to 6 days.
Agro-Morphological Variability of Wild Vigna Species Collected in Senegal
Authors: Dramé Demba , Bodian Amy , Fonceka Daniel , Tossim Hodo-Abalo , Diangar Mouhamadou Moussa , Nguepjop Joel Romaric , Sambakhe Diarietou , Sidybe Mamadou , Diouf Diaga
Published: November 2023

The domesticated Vigna species still need some of the beneficial characters that exist in the wild Vigna species, despite the improvements obtained so far. This study was carried out to enhance our understanding of the Senegalese wild Vigna diversity by exploring the agro-morphological characteristics of some accessions using 22 traits. The phenotyping was carried out in a shaded house for two consecutive rainy seasons (2021 and 2022) using the alpha-lattice experimental design with 55 accessions. Multiple correspondence analysis was carried out based on the qualitative traits, which showed considerable variability for the wild species (Vigna unguiculata var. spontanea, Vigna racemosa, Vigna radiata and the unidentified accession). The quantitative traits were subjected to statistical analysis using descriptive statistics and ANOVA. Our results revealed that ninety-five percent (95%) pod maturity ranged from 74.2 to 125.8 days in accession 3 of V. unguiculata and in accession 92 (V. racemosa), respectively. In addition, accession 14 of V. radiata recorded the highest weight for 100 seeds with a value of 4.8 g, while accession 18 of V. unguiculata had the lowest (1.48 g). The ANOVA showed significant differences for the accessions during each season (p ≤ 0.05). Seasonal effects (accession × season) were observed for some quantitative traits, such as the terminal leaflet length and width, time to 50% flowering and 95% pod maturity, pod length and 100-seed weight. Principal component analysis showed that reproductive traits, such as the time to 50% flowering, number of locules per pod, pod length, pod width and 100-seed weight, were the major traits that accounted for the variations among the wild Vigna accessions. The genetic relationship based on qualitative and quantitative traits showed three clusters among the wild Vigna accessions. Indeed, the diversity observed in this study could be used to select parents for breeding to improve the cultivated species of Vigna.
Contribution of Road Transport to Pakistan’s Air Pollution in the Urban Environment
Authors: Bajwa Abdullah Umair , Sheikh Hassan Aftab
Published: November 2023

The urban areas of Pakistan exhibit some of the world’s highest levels of air pollution, primarily due to sub-2.5 μm particulate emissions. This issue significantly impairs both the country’s economy and the quality of life of its residents. Road transport is a significant contributor to anthropogenic air pollution but there are discrepancies about the extent of its share. Source apportionment and sectoral inventory studies attribute anywhere between 5 and >80% of the total air pollution to vehicular sources. This uncertainty propagates into the transport policy interventions that are informed by such studies and can thus hinder the achievement of desired pollution mitigation targets. In an effort to reconcile such discrepancies and guide future studies and policy-making efforts, this paper critically reviews source apportionment studies conducted in the urban centres of Pakistan over the past two decades. The strengths and weaknesses of different approaches are compared, and results from the studies are discussed based on the emissions profile of Pakistan’s automotive fleet that emerges. Inconsistencies in the reporting of pollutant concentrations and interpreting their impacts without accounting for the relative disease burden of different pollutant species are found to be the major reasons for the large variations in the reported sectoral shares. At the end, a framework for regular air pollution monitoring and source tracking is proposed in which high-fidelity receptor-based studies inform lower-fidelity but economical sectoral inventory assessments.
Effect of Milking Vacuum and the Supplementation of Vitamin E and Se in Milk Quantity, Quality, and Hygiene of Mammary gland in Mountainous Greek Sheep
Authors: Mamatsios Konstantinos , Karatzia Maria-Anastasia , Manessis Georgios , Kasapidou Eleni , Bossis Ioannis , Basdagianni Zoitsa
Published: November 2023

The aim of this research was to study the effect of two machine milking vacuum levels on the quantitative and qualitative characteristics of milk and mammary gland hygiene of ewes, when vitamin E and Se were administrated supplementarily. The experiment was conducted at the Vlasti Research Station in the Greek province of West Macedonia. Ninety-six ewes of the Mountainous Greek sheep breed were used. Animals were separated in four equal groups of 24 ewes per group. A 2 × 2 factorial design was applied, with two milking vacuum levels (38 kPa and 46 kPa) and two rations, one supplemented with vitamin E (300 I.U.) and Se (3 mg/kg DM feed) and one without any vitamin E and Se supplementation. Six test days were assigned (evening and morning milkings) at 14-day intervals, from April to July. Following milk yield control, milk samples were collected for chemical composition and somatic cell count (SCC) determination. At the end of milking of each lot, the milk from the terminal receiver of the milking machine was received for the evaluation of total bacterial count (TBC). The results revealed that milk yield was improved considerably in the case of 46 kPa vacuum level. Moreover, the chemical composition of milk was not influenced by vacuum level; however, the administration of vitamin E and Se appeared to have a positive effect. Moreover, the addition of vitamin E and Se decreased somatic cell counts (number and log10) at the two assessed machine milking vacuum levels. In reference to TBC and their log10, significant differences were not observed at both milking vacuum levels, regardless of vitamin E and Se administration. Statistical analysis did not indicate any interactions between the factors that were studied. Therefore, it is concluded that the quantity of vitamin E and Se supplemented to the ration has a positive effect on decreasing SCC and consequent positive action in the hygiene of the mammary glands of machine milked ewes.
Resveratrol and Its Derivatives in Inflammatory Skin Disorders—Atopic Dermatitis and Psoriasis: A Review
Authors: Marko Monika , Pawliczak Rafał
Published: November 2023

Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases whose prevalence has increased worldwide in recent decades. These disorders contribute to patients’ decreased quality of life (QoL) and constitute a socioeconomic burden. New therapeutic options for AD and psoriasis based on natural compounds are being investigated. These include resveratrol (3,5,40-trihydroxystilbene) and its derivatives, which are produced by many plant species, including grapevines. Resveratrol has gained interest since the term “French Paradox”, which refers to improved cardiovascular outcomes despite a high-fat diet in the French population, was introduced. Resveratrol and its derivatives have demonstrated various health benefits. In addition to anti-cancer, anti-aging, and antibacterial effects, there are also anti-inflammatory and antioxidant effects that can affect the molecular pathways of inflammatory skin disorders. A comprehensive understanding of these mechanisms may help develop new therapies. Numerous in vivo and in vitro studies have been conducted on the therapeutic properties of natural compounds. However, regarding resveratrol and its derivatives in treating AD and psoriasis, there are still many unexplained mechanisms and a need for clinical trials. Considering this, in this review, we discuss and summarize the most critical research on resveratrol and its derivatives in animal and cell models mimicking AD and psoriasis.
Influence of Post-Harvest 1-Methylcyclopropene (1-MCP) Treatment and Refrigeration on Chemical Composition, Phenolic Profile and Antioxidant Modifications during Storage of Abate Fétel Pears
Authors: Tedeschi Paola , Marzocchi Silvia , Marchetti Nicola , Barba Francisco J. , Maietti Annalisa
Published: November 2023

‘Abate Fétel’, a winter cultivar, is the most important pear cultivar in Italy; its fruits are appreciated by consumers for their aroma, texture and balanced sweet and sour taste. Maintaining high-quality characteristics to prolong the shelf-life of fruit and preserve the sensory and nutritional quality is a priority for the food industry. The aim of our study was to test the effectiveness of 1-methylcyclopropene (1-MCP) and cold storage in prolonging the shelf-life of these fruits, which were harvested at maturity at two different times. This work focused on the effects of different storage treatments and two ripening times on (i) the chemical composition of Abate Fétel pulp fruits to preserve their sweet taste and aroma and (ii) the phenolic profile composition and antioxidant activity of the peel, which is naturally rich in phytochemicals and important for the fruit’s shelf-life and in the functional food industry for its high nutritional value. Abate Fétel fruits were harvested at the optimal commercial maturity stage, first on 15 September, having been treated with 1-MCP and stored for 2 months at cold temperatures; the other fruits were harvested at the end of September and stored in a cold cell for 2 months. The fruit pulp was tested for glucose and fructose, pH, acidity and organic acids (malic, citric, fumaric and shikimic), phenolic content and phenolic compounds (chlorogenic and caffeic acids, rutin, hyperoside, kaempferol-3-rutinoside and isoquercitrin), and the antioxidant activities in the fruit peels were measured. Treating the fruits with 1-MCP better preserved the phytochemical compounds compared to simple refrigeration, preserving the fruit’s quality and prolonging its shelf-life. All the treatments help to maintain the glucose and fructose content and the acidity, preserving the aroma and organoleptic characteristics.
A Wireless System for Monitoring Termite Activity Using Electromagnetic Induction with Non-Looping Method
Authors: Fang Zheng , Li Hongyue , Ma Yuanfei , Zhang Mei , Gao Siwei , Chen Bosheng , Shen Junfeng , Zhang Dayu
Published: November 2023

Termites can cause severe economic damage in households, reservoirs, agriculture, and forests. Monitoring termite activity plays an important role in integrated termite management. A device for the automatic monitoring of termites with high accuracy and reliability is highly demanded. Here, we introduce Dekan electromagnetic induction with non-looping (DEMINL) method and a novel wireless system for the monitoring of termite activities. The system comprises of a termite bait station and a handheld reader. While the wood pieces in the bait station were consumed by termites, the device could generate alarm signals, which are sent to a signal reader (receiver) through radio frequency identification (RFID) and displayed on the handheld reader’s screen. Field tests at three locations over a two-year period showed an accurate detection rate of 97.5–98.5%. The DEMINL-based device demonstrated high accuracy and durability in detecting termites, making it suitable for termite monitoring in households, crop fields, forests, and reservoirs.
Structure and Mechanical Properties of Milled and 3D-Printed Ti-6Al-4V Alloys for Subtractive and Additive CAD/CAM Manufacturing in Dentistry
Authors: Cherneva Sabina , Petrunov Vladimir , Petkov Vladimir , Bogdanov Vladimir , Simeonova Silviya
Published: November 2023

The mechanical properties, structure, and morphology of milled and 3D-printed Ti-6Al-4V alloys produced by selective laser melting were investigated in this study. The mechanical properties were investigated by means of nanoindentation, a tensile test, and a three-point bending test. An Atomic Force Microscope (AFM) was used to study the surface topography and roughness of both titanium alloys. The surface structure and phase analyses were studied by a scanning electron microscope (SEM) and through powder X-ray diffraction (XRD). The results from the nanoindentation experiments showed that the 3D-printed sample has higher indentation hardness and modulus than the milled one. The AFM observation of the surface topography of the samples showed that the milled sample has a higher roughness than the 3D-printed one. The tensile test results showed that the 3D-printed sample by means of Selective Laser Melting (SLM) technology has about 26% higher tensile strength and smaller elongation than the milled one. The three-point bending test revealed that the 3D-printed Ti-6Al-4V sample has higher flexural strength than the milled one. It was found that the 3D-printed sample has a smaller crystal size than the milled one, which, according to the Hall–Petch relationship, leads to its higher indentation hardness.
Semantic Similarity Based on Taxonomies
Authors: De Nicola Antonio , Formica Anna , Mele Ida , Taglino Francesco
Published: November 2023

The evaluation of the semantic similarity of concepts organized according to taxonomies is a long-standing problem in computer science and has attracted great attention from researchers over the decades. In this regard, the notion of information content plays a key role, and semantic similarity measures based on it are still on the rise. In this review, we address the methods for evaluating the semantic similarity between either concepts or sets of concepts belonging to a taxonomy that, often, in the literature, adopt different notations and formalisms. The results of this systematic literature review provide researchers and academics with insight into the notions that the methods discussed have in common through the use of the same notation, as well as their differences, overlaps, and dependencies, and, in particular, the role of the notion of information content in the evaluation of semantic similarity. Furthermore, in this review, a comparative analysis of the methods for evaluating the semantic similarity between sets of concepts is provided.
A Study on the Depositional Law of Road Cutting in the Tengger Desert
Authors: Yin Wen-Hua , Yue Huan , Wang Xu
Published: November 2023

In this study, the characteristics of wind-blown sand in the hinterland of the Tengger Desert and the regularity of sand deposition in road cutting are studied by combining a field test and numerical simulation. Firstly, the meteorological observation system is used to obtain the long-term monitoring of the Tengger Desert hinterland, and the perennial wind speed, wind direction, and strong wind period are obtained. Then, a three-dimensional ultrasonic anemometer and stepwise sand accumulation instrument are used to measure the transient wind-blown sand velocity and density at the top of the cutting slope, which provide the basis and verification for the numerical simulation. Finally, Fluent software (2020R2) is used to establish two numerical models with and without grading. Based on Euler’s two-fluid theory and fluctuating-wind user-defined functions, the movement of wind-blown sand in the cutting section of the desert hinterland is simulated, and the regularity of sand accumulation in the cutting section is obtained. The main conclusions are as follows: (1) The strong wind period in the hinterland of the Tengger Desert in 2021 mainly occurs from April to August, and the mainstream wind direction is concentrated in the WSW and SW directions. (2) The sand in the hinterland of the Tengger Desert is mainly medium–fine, and the particle size range is mainly concentrated at 0.075–0.250 mm, accounting for 98.2% of the total sand; the curve of the wind-blown sand density with height is oblique and L-shaped. (3) The method of grading excavation is beneficial to reduce the sand accumulation rate on the road’s surface.
R-PreNet: Deraining Network Based on Image Background Prior
Authors: Jiao Congyu , Meng Fanjie , Li Tingxuan , Cao Ying
Published: November 2023

Single image deraining (SID) has shown its importance in many advanced computer vision tasks. Although many CNN-based image deraining methods have been proposed, how to effectively remove raindrops while maintaining background structure remains a challenge that needs to be overcome. Most of the deraining work focuses on removing rain streaks, but in heavy rain images, the dense accumulation of rainwater or the rain curtain effect significantly interferes with the effective removal of rain streaks, and often introduces some artifacts that make the scene more blurry. In this paper, a novel network architecture, R-PReNet, is introduced for single image denoising with an emphasis on preserving the background structure. The framework effectively exploits the cyclic recursive structure inherent in PReNet. Additionally, the residual channel prior (RCP) and feature fusion modules have been incorporated, enhancing denoising performance by emphasizing background feature information. Compared with the previous methods, this approach offers notable improvement in rainstorm images by reducing artifacts and restoring visual details.
Efficient Non-Destructive Detection for External Defects of Kiwifruit
Authors: Wang Feiyun , Lv Chengxu , Pan Yuxuan , Zhou Liming , Zhao Bo
Published: November 2023

External defects of kiwifruit seriously affect its added commercialization. To address the existing problems, kiwifruit external defects detection has a few methods for detecting multi-category defects and weak adaptability to complex images. In this study, we proposed ResNet combined with CBAM for the automatic detection of external defects in kiwifruit. The experiment first built an acquisition device to obtain high-quality images. The optimal fusion scheme of ResNet and CBAM was investigated, the network training parameters were optimized, and Adam was used to accelerate the convergence speed of the model. It was found that the average recognition accuracy of ResNet34 + CBAM for kiwifruit was 99.6%, and all evaluation metrics were greater than 99%. Meanwhile, the experiment selected AlexNet, VGG16, InceptionV3, ResNet34, and ResNet34 + CBAM for comparison. The results showed that the recognition accuracy of ResNet34 + CBAM was 7.9%, 12.7%, 11.8%, and 4.3% higher than that of AlexNet, VGG16, InceptionV3, and ResNet34, respectively. Therefore, it can be concluded that ResNet34 + CBAM has the advantages of high recognition accuracy and good stability for kiwifruit external defect sample detection. It provides a technical guarantee for online detection and sorting of kiwifruit and other fruit defects.
Spectral Characteristics of Fluctuating Aerodynamic Forces Acting on Rectangular Prisms
Authors: Zeng Jiadong , Zhang Zhitian , Li Mingshui , Li Shaopeng
Published: November 2023

The present work is devoted to the role of boundary layer turbulence on the spectral characteristics of fluctuating wind loads on large aspect-ratio rectangular prisms. Seven rectangular rigid models with different side ratios (1/4~4) were created, and simultaneous pressure experiments were conducted under the boundary layer turbulence flows. Using the measured data, the power spectrums of the fluctuating aerodynamic forces were calculated, and then, the spectral characteristics under different turbulent boundary layer flows were analyzed. In contrast to the typical power spectrum model, the main factors affecting the spectral characteristics of the fluctuating aerodynamic loads are presented and discussed in this study. The power spectrum of the rectangular prism was significantly impacted by the turbulent wind field, primarily because higher turbulence intensity levels result in a lower spectral peak and a wider spectral bandwidth, which also redistributes spectral energy. In particular, the effect on the spectral properties of across-wind fluctuating loads was stronger, and the turbulent disturbance modified the lateral separation flow structure, causing the reattachment phenomenon to occur earlier on rectangular prisms with small side ratios, which effectively altered the spectral properties. Thus, a normalized across-wind fluctuating wind load spectrum model is proposed, taking into account the effects of incoming turbulence, the side ratio, vortex shedding, separation reattachment flow-induced spectral bandwidth changes, and high-frequency fluctuations.
Application of Physics-Informed Neural Networks to River Silting Simulation
Authors: Omarova Perizat , Amirgaliyev Yedilkhan , Kozbakova Ainur , Ataniyazova Aisulyu
Published: November 2023

Water resource pollution, particularly in river channels, presents a grave environmental challenge that necessitates a comprehensive and systematic approach encompassing assessment, forecasting, and effective management. This article provides a comprehensive exploration of the methodology and modeling tools employed to scrutinize the process of river channel pollution due to silting, rooted in the fundamental principles of hydrodynamics and pollutant transport dynamics. The study’s methodology seamlessly integrates numerical simulations with state-of-the-art neural network techniques, with a specific focus on the physics-informed neural network (PINN) method. This innovative approach represents a groundbreaking fusion of artificial neural networks (ANNs) and physical equations, offering a more efficient and precise means of modeling a wide array of complex processes and phenomena. The proposed mathematical model, grounded in the Euler equation, has been meticulously implemented using the Ansys Fluent software package, ensuring accuracy and reliability in the computations. In a pivotal phase of the research, a thorough comparative analysis was conducted between the results derived using the PINN method and those obtained using conventional numerical approaches with the Ansys Fluent software package. The outcomes of this analysis revealed the superior performance of the PINN method, characterized by the generation of smoother pressure fluctuation profiles and a significantly reduced computation time, underscoring its potential as a transformative modeling tool. The calculated data originating from this study assume paramount significance in the ongoing battle against river sedimentation. Beyond this immediate application, these findings also serve as a valuable resource for creating predictive materials pertaining to river channel silting, thereby empowering decision-makers and environmental stakeholders with essential information. The utilization of modeling techniques to address pollution concerns in river channels holds the potential to revolutionize risk management and safeguard the integrity of our vital water resources. However, it is imperative to underscore that the effectiveness of such models hinges on ongoing monitoring and frequent data updates, ensuring that they remain aligned with real-world conditions. This research not only contributes to the enhanced understanding and proactive management of river channel pollution due to silting but also underscores the pivotal role of advanced modeling methodologies in the preservation of our invaluable water resources for present and future generations.
Universal Behavior of the Image Resolution for Different Scanning Trajectories
Authors: Mukhatov Azamat , Le Tuan-Anh , Do Ton Duc , Pham Tri T.
Published: November 2023

This study examines the characteristics of various scanning trajectories or patterns under the influence of scanning parameters in order to develop a theory to define their corresponding image resolutions. The lack of an accurate estimation of pixel size for a specified set of scanning parameters and their connection is a key challenge with existing scanning methods. Thus, this research aimed to propose a novel approach to estimate the pixel size of different scanning techniques. The findings showed that there is a link between pixel size and a frequency ratio NP, which is the ratio of two waveform frequencies that regulates the density of the scanning pattern. A theory has been developed in this study to explain the relationship between scanning parameters and scanning density or pixel size, which was not previously considered. This unique theory permitted the a priori estimate of the image resolution using a particular set of scanning parameters, including the scan time, frequencies, frequency ratio, and their amplitudes. This paper presents a novel and systematic approach for estimating the pixel size of various scanning trajectories, offering the user additional flexibility in adjusting the scanning time or frequency to achieve the desired resolution. Our findings also reveal that in order to achieve a high-quality image with high signal-to-noise and low error, the scanning trajectory must be able to generate a fairly uniform or regular pattern with a small pixel size.