bluuebunny/crossref_metadata_2025 huggingface dataset:
Meng Jinghui’s adaptations of Vladimir Mayakovsky’s plays
Authors: Liu Jingling , Monisova Irina V.
Published: March 2024

Vladimir Mayakovsky’s dramatic heritage has had a great impact on Chinese avant-garde director and playwright Meng Jinghui. The study traces the stages of Mayakovsky’s presence in Chinese theater art to focus on Meng Jinghui’s three productions of “The Bedbug” (2000-2017). The dramatists share the same desire for theatrical innovation and a similar understanding of theater art. However, they have different worldviews and aesthetic approaches. Meng Jinghui modernized the original Russian pretext and turned to some theatrical principles, first stipulated by Vsevolod Meyerhold. His remakes are stylistically original textual interpretations that have gained a prominent place in the modern Chinese avant-garde fringe theater. Meng Jinghui followed Mayakovsky in a number of formal techniques and the overall satirical orientation only to reshape and deconstruct the basic ideas of the original play, thus creating a different temporal and cultural chronotope. Authentic as it may seem, Meng Jinghui creativity results sprouted from a dialogue and polemics with the Soviet poet and playwright.
V. Khlebnikov’s “Bobaobi sang lips...” in Chinese reception
Authors: Liu Chao , Kuzmishcheva Natalya M.
Published: March 2024

At the turn of the 20th and 21st centuries in China, the understanding of the modernist trends of the Russian Silver Age deepened and expanded. The perception of futurism is subject to scientific and creative rethinking. The number of representatives of the Russian futurist movement who deserve the attention of Chinese specialists in translation, research, and critical activities is increasing. The reception of V. Khlebnikov’s work, taking into account the comprehension of futurist aesthetics and his poetic theory, determines the problems of modern Chinese studies of Russian futurism. The authors examine the theoretical and practical reception of V. Khlebnikov’s works in China, analyze the perception of V. Khlebnikov’s work by two Chinese specialists - Wang Zonghu (the main expert in the theory of abstruse language) and Zheng Tiwu (the main translator of the poet’s work in China). Identification of the degree of adequacy of the perception of the poet’s language experiments is carried out using the example of a comparative analysis of translations of the poem “Bobeobi lips sang…” into Chinese. The Chinese reader owes the discovery of V. Khlebnikov as the theorist and founder of Russian futurism to the skill of researchers and translators.
Crisis of political communication: is there a silencing effect in Russian media?
Authors: Dolgova Yulia I. , Gulenko Petr V.
Published: March 2024

The authors investigate the agenda of the so-called ‘big three’ TV channels and popular online media during the presidential elections 2018 in Russia. In the context of an election campaign, the significance of qualitative public awareness grows exponentially. The given research studies the agenda of those media, the coverage of the election campaign, and also the possible ‘silencing effect’. An unique research design that allowed the content comparison between evening TV news and online media is developed, and also the notion of ‘silencing effect’ is conceptualized. Online media are often considered more qualitative and full-fledged sources of information; nevertheless, the research demonstrates that information concerned the elections was published on the Internet on a smaller scale and irregularly. The study confirmed that television in Russia, first of all, was an assistant to the government, directing its efforts to inform citizens about authorities and their socially significant initiatives. Besides, television covered the presidential elections in a better extent. Online media devoted more attention to scandalous news, attempted to criticize the government; however, they overlooked significant social issues.
Media of the future and future conflicts: what changes to expect with the development of AI technologies: an interview with Professor Ketan Kotecha
Authors: Bulgarova Bella A. , Kotecha Ketan
Published: March 2024

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Relevance of Hermann Hesse: a systematic review of different perspectives
Authors: Jose Antony , Grace V.M. Berlin , Jose Jibin , Wilson D. David
Published: March 2024

During the first decades of the 20th century, many European intellectuals were developing negative responses to modernity. Hermann Hesse was aware of the moral and social difficulties plaguing Europe at that time and dealt with these problems in his writing. Despite being a German author, he is well read even today, and his characters' quests and journeys of self-discovery captivate young people worldwide. This study aims to bring out the relevance of Hesse by analysing the historiography of the studies on Hesse's works and interrogating the significance of different perspectives on him, which will open doors for future studies in health humanities and memory studies. The authors systematically analyse 100 studies on Hesse and his works from journals indexed in the Web of Science. It is concluded that Hesse’s literary world, comprised of novels, poems, and autobiographical reflections, is deeper and bigger than what has been discovered.
LOCATING LEARNER-CENTERED INSTRUCTION IN ISLAMIC BOARDING SCHOOLS’ CLASSROOMS: PROSPECTS AND CHALLENGES
Authors: Emawati Emawati , Zulfikar Teuku , Habiburrahim Habiburrahim , Akmal Saiful , Sundusiyah Anis
Published: March 2024

Progressive Education (PE) aims to promote students' active participation and involvement in the learning process. PE strongly supports learner-centered instruction (LCI), enabling students to be active participants rather than passive recipients of knowledge. Nevertheless, the LCI has not yet gained popularity in the Indonesian school settings, particularly in Modern Islamic Boarding Schools. This enables us to do research on the potential and obstacles of implementing the LCI as required by Progressive Education in Islamic boarding schools. Data for this qualitative study was gathered through Focus Group Discussions (FGDs), in-depth interviews and an online communication with 24 teachers from Islamic Boarding Schools in the province of Aceh. The findings indicate that although worries about the issues of the LCI are still arising, the teachers involved in this research believe that the LCI has promising prospects in the near future. The finding also found that although the LCI is considered an efficient method for facilitating optimal learning, it is deemed to be less successful in some courses.
MANAGING FINANCING RISK OF ISLAMIC BANKING PRODUCTS IN INDONESIA: A VALUE AT RISK APPROACH
Authors: Sari Nilam , Ibrahim Azharsyah , Muzammil Muzammil , Muksal Muksal
Published: March 2024

This study aims to assess the potential risk and anticipated returns of equity and debt-based financing products in Islamic banking in Indonesia, represented by the three most prevalent contracts: musharakah, mudharabah, and murabahah. Data was collected from banks' monthly financial reports published on the Indonesia Financial Service Authority (OJK) website from 2014 to 2020, resulting in 82 observations. Data analysis was conducted using the Value at Risk (VaR) method with the variance-covariance approach. Among many methods, VaR is one of the most popular techniques that yields the most comprehensive results in measuring risk and return. The findings reveal that, in general, all equity and debt-based financing yielded stable risk and returns. However, equity-based financing produced higher returns, but also generated higher risks due to its uncertain nature. The results also demonstrate that risk management in Islamic banks improved gradually during the observation period, as indicated by the average score of portfolio combinations. These findings suggest that Islamic banks should balance their product offerings between equity-based financing and debt-based financing while simultaneously strengthening risk management, especially for murabahah products in equity-based financing.
HAJJ HEALTH ISTITA'AH FROM THE PERSPECTIVE OF HEALTH DECENTRALIZATION
Authors: Ishom Muhammad , Abdurrouf Muh. , Zaini Ahmad , Jamaludin Jambunanda Ahmad
Published: March 2024

This study aims to analyse the implementation of hajj health istiţa'ah at the district / city level. Based on Minister of Health Regulation Number 15/2016 concerning the Health istiţa'ah of hajj Pilgrims, the examination and health guidance of hajj pilgrims to meet the hajj health istiţa'ah has been mandated to the District/City hajj health organizing team. Hajj health examination and guidance at the first and second levels is not only the responsibility of individual prospective pilgrims, but also the government and the community. This study collected and analysed data using a qualitative legal approachh. The findings of this study identified both supporting and inhibiting factors affecting the implementation of hajj health istiţa'ah provisions. These factors are primarily associated with the absence of regulations at the regency/city level governing the organization of the Hajj. Most local governments have enacted regional regulations pertaining solely to Hajj transportation. In contrast, the security system for the Hajj in these areas relies solely on the technical guidelines provided by Permenkes No. 15/2016. This study highlights the critical need to enhance Hajj health istiţa'ah regulations by establishing district/city-level regulations.

Abstrak: Studi ini bertujuan menganalisis implementasi pemenuhan istiţa’ah kesehatan haji pada level kabupaten/kota. Berdasarkan Permenkes Nomor 15/2016 Tentang istiţa’ah Kesehatan Jemaah Haji, pemeriksaan dan pembinaan kesehatan jemaah haji supaya memenuhi istiţa’ah kesehatan haji telah diamanatkan kepada tim penyelenggara kesehatan haji Kabupaten/Kota. Pemeriksaan dan pembinaan kesehatan haji di level pertama dan level kedua bukan hanya menjadi tanggungjawab individu calon jemaah haji, melainkan pemerintah dan juga masyarakat. Dari data yang dihimpun dan dianalisis menggunakan pendekatan hukum kualitatif dalam studi ini dideskrispikan adanya faktor pendukung dan faktor penghambat implementasi ketentuan istiţa’ah kesehatan haji. Faktor-faktor itu berhubungan dengan minimnya pemerintahan daerah di tingkat kabupaten/kota yang memiliki peraturan penyelenggaraan haji di daerah. Mayoritas pemerintahan daerah hanya memiliki peraturan daerah tentang transportasi haji, sementara dalam sistem survielan kesejatan haji di daerah hanya mengacu kepada petunjuk teknis (Juknis) Permenkes No. 15/2016. Studi ini merekomendasikan pentingnya penguatan aturan istiţa’ah kesehatan haji yang diatur dalam regulasi daerah kabupaten/kota.

Kata Kunci: Istiţa’ah, Kesehatan haji, Desentralisasi
CHILDREN'S RIGHTS IN A QUASI BROKEN HOME PERSPECTIVE OF ISLAMIC LAW AND LAW NUMBER 35 OF 2014 CONCERNING CHILD PROTECTION
Authors: Muharrani  , Zulkarnain  , Miswari  , Azwir  , Mawardi
Published: March 2024

Abstract: In modern society, many symptoms of a quasi broken home are found in a family. This results in communication between children and parents being disturbed, the family becoming disharmonious and children's attitudes tending to become naughty. The aims of this research are (1) to determine children's rights in quasi broken homes in West Langsa District, (2) to determine the perspective of Islamic law and Law Number 35 of 2014 on the practice of fulfilling children's rights in quasi broken homes in West Langsa District and (3) to determine the similarities and differences between the perspective of Islamic law and Law Number 35 of 2014 regarding the practice of fulfilling children's rights in quasi broken homes in West Langsa District. This research uses a normative empirical approach and the type of research is field research. To obtain data, researchers used observation, interviews and documentation methods. The results of this research show that (1) children's rights in quasi broken homes in West Langsa District are not implemented well because parents are busy at work. (2) The perspective of Islamic law and Law Number 35 of 2014 on the practice of fulfilling children's rights in quasi broken homes in West Langsa District, namely in fulfilling the right to life, the right to education, the right to voice and participate and the right to fulfill identity and inheritance has been fulfilled properly. However, children's rights related to protection from violence have not been fulfilled properly and children's rights related to the provision of love and care are also not fulfilled properly because parents are busy. (3) The similarities and differences between the perspective of Islamic law and Law Number 35 of 2014 regarding the practice of fulfilling children's rights in a quasi broken home in West Langsa District can be seen in the fulfillment of children's education where in Islamic law children's education consists of formal education which is worldly in nature and religious education, whereas in Law Number 35 of 2014 it is only limited to education adapted to the child's talents and interests. Apart from that, another difference lies in Law Number 35 of 2014 which also states the child's right to be able to be cared for by someone other than their parents.
20th Century Congolese Novel. Typology and National Specifics
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Lyahovskaya Nina D.
Published: March 2024

The monograph explores the ideological and artistic paradigm of the French-speaking Congolese novel during the 20th century development: anti-colonial orientation, protection of spiritual and material values of Africa, connection with oral tradition and participation in the world literary process. Four main patterns of the development of Congolese novelistics are analyzed: 1) French-speaking with a tendency to create “mestizo” writing, using of a local linguistic substrate; 2) super-accelerated development of adapted European novel forms; 3) the combination of different artistic trends of the literary process in the 20th century; 4) hybridization of genres and innovative individual author transformation oral tradition elements. The first chapter is devoted to the work of Congolese novelistics founders; the second chapter analyzes the varieties of the realistic direction; the third — the specifics of postmodernism (plus ultra). The monograph is intended for students, specialists-philologists, teachers of higher and secondary schools, as well as for a wide range of readers interested in African culture.
Microbial DNA extraction method for avian feces and preen oil from diverse species
Authors: Russell Austin , Kenna Margaret , Huynh Alex , Rice Amber
Published: March 2024

As DNA sequencing technology continues to rapidly improve, studies
investigating the microbial communities of host organisms (i.e.,
microbiomes) are becoming not only more popular but also more
financially accessible. Across many taxa, microbiomes can have important
impacts on organismal health and fitness. To evaluate the microbial
community composition of a particular microbiome, microbial DNA must be
successfully extracted. Fecal samples are often easy to collect and are
a good source of gut microbial DNA. Additionally, interest in the avian
preen gland microbiome is rapidly growing, due to the importance of
preen oil for many aspects of avian life. Microbial DNA extractions from
avian fecal and preen oil samples present multiple challenges, however.
Here, we describe a modified PrepMan Ultra Sample Preparation Reagent
microbial DNA extraction method that is less expensive than other
commonly used methodologies and is highly effective for both fecal and
preen oil samples collected from a broad range of avian species. We
expect our method will facilitate microbial DNA extractions from
multiple avian microbiome reservoirs, which have previously proved
difficult and expensive. Our method therefore increases the feasibility
of future studies of avian host microbiomes.
Comparative mitogenome research revealed the phylogenetics and evolution of the superfamily Tenebrionoidea (Coleoptera: Polyphage)
Authors: Hu Yun-Jian , Hu Li , Wu Chuan , Tian Tian , Li Ting-Jing , Chen Bin
Published: March 2024

Despite the worldwide distribution and rich diversity of the superfamily
Tenebrionoidea, the knowledge of the mitochondrial genomes (mtgenome)
characteristics of the superfamily is still very limited and its
phylogenetics and evolution remains unresolved. In present study,
nineteen species of mtgenomes in Tenebrionoidea are newly sequenced and
annotated, and a total of 90 mtgenomes are analyzed. There exist 37
genes for all 82 species of complete mtgenomes of 16 families
investigated, and their characteristics are identical as reported
mtgenomes of other Tenebrionoids. The Ka/Ks analysis suggests that all
13 PCGs have undergone a strong purifying selection. The phylogenetic
analysis suggests the monophyly of Mordellidae, Ripiphoridae, Meloidae,
Anthicidae, Oedemeridae, Pyrochroidae, Salpingidae, Scraptiidae,
Lagriidae and Tenebrionidae, and the Mordellidae is sister to the
Ripiphoridae. The “Tenebrionidae clade” and “Meloidae clade” are
monophyletic, and both of them are sister groups. In the “Meloidae
clade”, Anthicidae is sister to Meloidae. In the “Tenebrionidae
clade”, the family Lagriidae and Tenebrionidae are sister groups. The
divergence time analysis suggests that Tenebrionoidea originated in
early Jurassic, Mordellidae, Meloidae and Oedemeridae in Cretaceous,
Anthicidae, Lagriidae and Tenebrionidae in the early Cretaceous. The
work lays a base for the study of mtgenome, phylogenetics and evolution
of the superfamily Tenebrionoidea.
Treatment Satisfaction and effects: A Pilot Feasibility Study of Schema Therapy in Adult Outpatients with Personality Disorders within a Day Treatment Program
Authors: Broersen Jenny , Vreeswijk Michiel van
Published: March 2024

Objective: This study aims to evaluate the effectiveness and patient
satisfaction of Group Schema Therapy-Day Treatment (GST-d) in treating
individuals with cluster B/C personality disorders. Method: The study
utilized a naturalistic design with 39 patients undergoing 34 weeks of
combined group and individual schema therapy. This included weekly
full-day GST-d sessions, 15 individual sessions, and two group
follow-ups. Results: Significant reductions were observed in
psychological symptoms, personality issues, and dysfunctional schemas,
with effect sizes (Cohen d’s) ranging from .77 to .87. Healthy modes
showed a smaller effect size of .24. The dropout rate was 17.9%, but
overall patient satisfaction remained high. Conclusions: The findings
suggest the potential effectiveness of GST-d in treating personality
disorders. Despite some limitations, the study recommends further
research with a larger sample and randomized control trials to better
understand the relationship between patient satisfaction and treatment
outcome, as well as cost-effectiveness.
Existence results for nonlinear fractional differential equations with integral initial value conditions involving Hilfer fractional derivatives
Authors: HE Yu-bo , ZHOU Jue-liang , Qian Hongchao
Published: March 2024

In this paper, we consider the existence results for nonlinear Hilfer
fractional differential equations with integral initial value conditions
on finite interval [0 ,T]. Sufficient conditions for the
existence of solution for the initial value problem are obtained by
Schaefer’s fixed point theorem in constructed Banach Space.
Leaf day respiration: more than just catabolic CO 2 production in the light
Authors: Tcherkez Guillaume , Abadie Cyril , Dourmap Corentin , Lalande Julie , Limami Anis
Published: March 2024

Illuminated leaves assimilate CO via gross
photosynthesis and liberate CO via photorespiration
and ‘day respiration’, often denoted as R. Day
respiration is a minor CO -exchange component of net
photosynthesis but is important for carbon use efficiency, computations
of internal conductance, or the interpretation of net photosynthetic
C/ C fractionation.
Unfortunately, there is no simple method to measure R and tracing the origin of C-atoms found in
day-respired CO is difficult. As a result, a common
misconception is that day respiration is simply a catabolic, CO
-producing flux through ordinary catabolism (glycolysis
and Krebs ‘cycle’). In the past few years, considerable progress has
been made in our understanding of day respiration. It appears that
R is a net flux resulting from several CO
-generating and CO -fixing reactions,
not only related to catabolism but also to anabolism (biosyntheses). In
addition, there is now direct evidence that decarboxylating reactions
are partly fed by carbon sources disconnected from current
photosynthesis and this effect has consequences for isotopic
mass-balance. Therefore, leaf day ‘respiration’ is much more than just
CO production by respiratory catabolism. Rather, it
reflects whole metabolic orchestration of leaves from N fixation to
secondary metabolism and it perhaps deserves another name, such as “day
decarboxylations”.
Impacts of Interannual Rainfall Variability and Intensification of the Hydrologic Cycle on Groundwater in a Micro-Watershed in the Amazon Rainforest
Authors: Brito Alderlene Pimentel de , Ferreira Sávio José Filgueiras , Gastmans Didier , PINEL Sebastien , Tomasella Javier , Silva Márcio Luiz da , Bastos Alexandre Souza , Brito Walter Lucas Pimentel de , Santarosa Lucas , Santos Zayra Christine Sátyro dos
Published: March 2024

Climate change in the Amazon includes the intensification of the
hydrological cycle in association with the increase of extreme events.
This study aims to identify the impacts on groundwater (GW) within a
pristine micro-scale catchment in the Central Amazon related to the
observed alterations on hydrological cycle. Precipitation and GW levels
from seven piezometers distributed along a hydrological transect
covering three zones (lowland, slope and plateau) were collected for the
period 2001-2021. External (evapotranspiration, GW storage and climate
patterns) and computed (annual recharge) data were used to strengthen
the analyses. We identified a generalized growth trend in all
compartments (rainfall, evaporation and water table). There was a
heterogeneity in water table fluctuations and annual recharge, depending
on distance from creek channel and water depth. Surface processes
influenced shallows piezometers associated with rapid overflow and low
recharge. Conversely, deep piezometers involved slower processes related
to water movement, and were more representative of regional GW. Those
presented larger seasonal and inter-annual fluctuations, annual recharge
and positive trend than shallow piezometers. Besides, all piezometers
showed large inter-annual variations in recharge. The El Niño-Southern
Oscillation (ENSO) influenced GW level, recharge and storage: positive
phase contributed to lower all variables, with recovery in during
neutral and negative phase. The larger positive trends in the deeper
piezometers are a sign of the resilience of the Alter do Chão aquifer,
subject to anthropogenic pressure. As water table play a key-role in
shaping the structure and productivity of Amazon forests, further
hydro-ecological studies should be conducted to gather information about
the fate of GW-dependent Amazonian ecosystems.
Temporal gamma tACS and auditory stimulation affect verbal memory in healthy adults
Authors: Manippa Valerio , Nitsche Michael A , Filardi Marco , Vilella Davide , Scianatico Gaetano , Logroscino Giancarlo , Rivolta Davide
Published: March 2024

Research suggests a potential of gamma oscillation entrainment for
enhancing memory in Alzheimer’s disease and healthy subjects. Gamma
entrainment can be accomplished with oscillatory electrical, but also
sensory stimulation. However, comparative studies between sensory
stimulation and transcranial alternating current stimulation (tACS)
effects on memory processes are lacking. This study examined the effects
of rhythmic gamma auditory stimulation (rAS) and temporal gamma-tACS on
verbal long-term memory (LTM) and working memory (WM) in 74 healthy
individuals. Participants were assigned to two groups according to the
stimulation techniques (rAS or tACS). Memory was assessed in three
experimental blocks, in which each participant was administered with
control, 40 Hz, and 60 Hz stimulation in counterbalanced order. All
interventions were well-tolerated, and participants reported mostly
comparable side effects between real stimulation (40 Hz and 60 Hz) and
the control condition. LTM immediate and delayed recall remained
unaffected by stimulations, while immediate recall intrusions decreased
during 60 Hz stimulation. Notably, 40 Hz interventions improved WM
compared to control stimulations. These results highlight the potential
of 60 Hz and 40 Hz temporal cortex stimulation for reducing immediate
LTM recall intrusions and improving WM performance, respectively,
probably due to the entrainment of specific gamma oscillations in the
auditory cortex. The results also shed light on the comparative effects
of these neuromodulation tools on memory functions, and their potential
applications for cognitive enhancement and in clinical trials.
A Novel Approach to Detect Nanoparticle Concentration Using Active Cavity WGM Sensor
Authors: Et-Tijani El Metouy , Poffo Luiz , Velly Christelle , Féron Patrice , Abel-Tiberini Laetitia
Published: March 2024

This paper presents a new approach to nanoparticle detection
using an active micro-resonator operating in the transparency regime.
Simulations demonstrate that when nanoparticles interact with the
micro-resonator surface, they induce optical losses. To compensate for
these losses, the optical gain is amplified to restore the transparency
regime. Simulation results show a linear relationship between
nanoparticle concentration and the pump power required to compensate for
optical losses. By the use of micro-resonator with a very high quality
factor, this approach offers an accurate and sensitive method for
detecting nanoparticles, without the need for complex equipment.
Research on sampling duty ratio in interrupted sampling repeater jamming
Authors: Qi Jianchi , Li Shengyong , Chen Jian , Li Hongke
Published: March 2024

Interrupted sampling repeater jamming (ISRJ) is an effective jamming
method in modern electronic countermeasures, but its sampling duty ratio
(SDR) should be no more than 50%. This paper proposes a distributed
interrupted sampling repeater jamming solution to settle this problem
based on the basic principle of the ISRJ. The simulation results show
that this solution can break the limit of the SDR, and overcome the
inherent defects of a single ISRJ jammer.
Preparation of low viscosity waterborne anti-counterfeiting ink based on dual luminescent nanohybrids of lanthanide-nitrogen co-modified GQDs and bacterial cellulose nanocrystals
Authors: Shi Ce , Jia Zhixin , Ji Zengtao , Yang Xinting , Sun Xia , Guo Yemin
Published: March 2024

Bacterial cellulose nanocrystals (BCNC) have gained significant study
attention in the field of anti-counterfeiting due to the advantages in
viscosity regulation, suspension stability, printability, and
shear-thinning behavior. In this study, a novel nanohybrids was
developed by electrostatically self-assembling BCNC with lanthanide (Er,
Yb)-nitrogen (N) co-modified graphene quantum dots (GQDs). These
nanohybrids were then incorporated into a polyvinyl alcohol (PVA)
waterborne ink, leveraging the unique rheological properties of BCNC to
form a stable network architecture. The incorporation resulted in
improved thixotropic behavior and increased yield stress of the PVA
waterborne ink, thereby enabling a more systematic approach to the
design and successful synthesis of a waterborne fluorescent ink used for
dual anticounterfeiting purposes. The synthesized Er/Yb/N-GQDs
demonstrated both photoluminescence (blue light) and upconversion
luminescence (green light) characteristics upon excitation at
wavelengths of 370 nm and 980 nm, respectively. Therefore, effective
information extraction necessitated the concurrent use of two distinct
excitation light sources, thereby heightened the difficulty of illicit
counterfeiting. This study introduced a waterborne fluorescent dual
anticounterfeiting ink with significant potential for applications in
information security and identity authentication. Moreover, it served as
a valuable reference for its adoption in the printing and packaging
industries.
Impact of Medicines Withdrawals and Revocations on Morbidity in France, Germany, and the United Kingdom
Authors: Lynn Elizabeth , Lane Samantha , Shakir Saad
Published: March 2024

Purpose: Removing medicines from market may benefit public
health by preventing adverse drug reactions (ADRs), which should be
quantified. This study’s aim was to identify a model to quantify the
impact of medicines’ marketing authorisation (MA) withdrawal and
revocation in terms of morbidity and mortality. Methods: MA
withdrawals and revocations for safety reasons in France, Germany,
and/or the United Kingdom (UK) between July 2012 and December 2016 were
identified for prescription medicines. Annual exposure was estimated for
each medicine, using IQVIA Medical Research Data (IMRD)-France,
IMRD-Germany, and IMRD-UK primary care electronic health record
databases. European Medicines Agency records provided reasons for
regulatory action for each medicine. Absolute risks of ADRs in patients
exposed to each medicine were estimated by systematic review of
quantitative research. Public health impact, expressed as annual number
of ADRs avoided, was estimated by modelling exposure and ADR risk.
Results: Four MA withdrawals and two revocations met study
inclusion criteria. Each product’s usage decreased following MA
withdrawal or revocation. Absolute risk for ADRs was 0.1-41.25%. To
estimate impact of each withdrawal or revocation, its average annual
exposure within each IMRD population was multiplied by the absolute risk
to give the crude number of ADRs prevented annually due to regulatory
action. Conclusions: This model quantifies the public health
impact of MA withdrawal and revocation in terms of serious morbidity,
resulting from eliminated or reduced usage of medicines. This method can
be applied to products in other settings to quantify the impact of other
pharmacovigilance actions.
Leveraging wastewater surveillance to actively monitor Covid-19 community dynamics in rural areas with reduced reliance on clinical testing
Authors: Jarvie Michelle M. , Nguyen Thu N.T. , Southwell Benjamin , Wright Derek
Published: March 2024

The prevalence of COVID-19 in the community has become more difficult to
gauge utilizing clinical testing due to a decrease in reported test
results stemming from the availability of at-home test kits and a
reduction in the number of cases seeking medical treatment. The purpose
of this study was to examine the trend of diminishing correlation
between reported clinical cases of COVID-19 and wastewater-based
surveillance epidemiological data as home testing became available in
the Eastern Upper Peninsula of Michigan. Wastewater grab samples were
collected weekly from 16 regional locations from June 2021-December
2022. Samples were analyzed for SARS-CoV-2 N1 and N2 viral particles
using reverse transcriptase digital droplet polymerase chain reaction
(RT ddPCR). N1 and N2 gene copies were correlated with clinical cases.
The t-test was used to determine correlation deterioration point.
Clinical cases post-deterioration were calculated for high-correlated
pre-deterioration locations using linear regression. Correlation between
the wastewater-based surveillance of SARS-CoV-2 and reported clinical
cases deteriorated after February 1, 2022. This corresponds with the
timeframe in which commercially available at-home test kits became
available in the United States. The increase in at-home testing for
SARS-CoV-2 likely contributed to the decrease in reported clinical
positive tests in early 2022, providing an unrealistic picture of the
presence of Covid-19 in the community. As measures to reduce exposure
such as personal masking, clinical testing, social isolating, and
quarantining continue to decline, wastewater surveillance for the
presence of SARS-CoV-2 may be the best method for public health
professionals to remain aware of virus dynamics in localized regions.
Time-series modeling adds another layer of information when clinical
data is unobtainable or underreported.
Do occupational health policies in China really work for residents? --Analyzing synthetic control based on text mining
Authors: Wang Yiwen , Li Shanshan , Niu Ben , Fan Mingxuan
Published: March 2024

Measuring and providing feedback on residents’ attention to occupational
health issues is of significant importance for the optimization of
relevant policies. This study focuses on the Thirteenth Five-Year Plan
for the Control of Occupational Disease Hazards (13th FYP CODH), using
text mining techniques to capture the residents’ attention to
occupational health issues in provinces from 2013 to 2021. Based on the
synthetic control method, a counterfactual comparison unit was
constructed to compare the differences between the actual and synthetic
values of residents’ attention rate to evaluate the implementation
effect of the13th FYP CODH. The results indicate that, regarding
residents’ attention rates, the13th FYP CODH has a brief promotional
effect on the attention levels of residents in the responsive provinces.
As the policy efficacy undergoes periods of strong effectiveness,
fatigue, and revival, the residents’ attention rates exhibit a
“U”-shaped evolving trend. In terms of synthetic control differences,
compared to Hunan, Shandong province experiences positive policy effects
only during the period of strong effectiveness. As time progresses, the
policy effects become less apparent, indicating a phenomenon of
“subsequent weakening” in policy efficacy. Additionally, medical and
health conditions, urbanization level, and technological innovation
capacity positively moderate the implementation effects of the13th FYP
CODH while industrial structure exerts a negative moderating effect on
its implementation effects. This study examines the policy effects of
China’s occupational health policy from the perspective of residents’
attention levels, offering insights that are intuitive, sustainable, and
implementable.
The sensitivity of regional sea level changes to the depth of Antarctic meltwater fluxes
Authors: Eisenman Ian , Basinski-Ferris Aurora , Beer Emma , Zanna Laure
Published: March 2024

Regional patterns of sea level rise are affected by a range of factors
including glacial melting, which has occurred in recent decades and is
projected to increase in the future, perhaps dramatically. Previous
modeling studies have typically included fluxes from melting glacial ice
only as a surface forcing of the ocean or as an offline addition to the
sea surface height fields produced by climate models. However,
observational estimates suggest that the majority of the meltwater from
the Antarctic Ice Sheet actually enters the ocean at depth through ice
shelf basal melt. Here we use simulations with an ocean general
circulation model in an idealized configuration. The results show that
the simulated global sea level rise pattern is sensitive to the depth at
which Antarctic meltwater enters the ocean. Further analysis suggests
that the response is dictated primarily by the steric response to the
depth of the meltwater flux.
An initial assessment of volcanic meteo-tsunamis hazard in the South China Sea shows considerable bathymetric effects
Authors: Verolino Andrea , Watanabe Masashi , Felix Raquel , Conway Christopher , Switzer Adam
Published: March 2024

Volcanic meteo-tsunamis, though rare, can pose significant threats to
people, as exemplified by the 2022 Hunga Tonga – Hunga Ha’apai (HT-HH)
eruption in the SW Pacific. While various studies have delved into the
complexities of such phenomena, none have explored analogous scenarios
in regions with potential occurrence of large eruptions near or under
the sea. We focus on coastal areas along the South China Sea (SCS),
among the most densely populated on Earth and historically prone to
volcanic activity, including the catastrophic 1883 Krakatau eruption.
Here we strategically chose one intra-basin volcano, KW-23612 in the
northern SCS, and three extra-basin volcanoes, Banua Wuhu in the Celebes
Sea, and Kikai and Fukutoku-Oka-no-Ba in the northern Philippines Sea
(southern Japan), from which we simulated volcanic meteo-tsunamis with
scaled intensities of the HT-HH event, to assess which countries around
the SCS could be more at risk from the occurrence of such phenomena. Our
results show that the worst-case scenarios are produced by
eruption/tsunamis from the northern SCS, producing offshore waves up to
10 cm offshore Macau and Hong Kong, and up to 20 cm offshore Manila. In
contrast, countries bordering the shallow Sunda Shelf (Malaysia,
Thailand, Cambodia, and southern Vietnam) seem less at risk from
volcanic meteo-tsunamis, though we observed some amplification effects
along the deeper Singapore Strait. This study is the first of its kind
in the region and sets the basis to investigate amplification effects,
and shallow coastal dynamics at key locations, after integrating higher
resolution bathymetry data.
Identifying and quantifying the impact of climatic and non-climatic drivers on river discharge in Europe
Authors: Collignan Julie , Polcher Jan , Bastin Sophie , Quintana-Seguí Pere
Published: March 2024

Our water resources have changed over the last century through a
combination of water management evolutions and climate change.
Understanding and decomposing these drivers of discharge changes is
essential to preparing and planning adaptive strategies. We propose a
methodology combining a physical-based model to reproduce the natural
behavior of river catchments and a parsimonious model to serve as a
framework of interpretation, comparing the physical-based model outputs
to observations of discharge trends. We show that over Europe,
especially in the South, the dominant explanations for discharge trends
are non-climatic factors. Still, in some catchments of Northern Europe,
climate change seems to be the dominating driver of change. We
hypothesize that the dominating non-climatic factors are irrigation
development, groundwater pumping and other human water usage, which need
to be taken into account in physical-based models to understand the main
drivers of discharge and project future changes.
Some effect of drift of the generalized Brownian motion process: Existence of the operator-valued generalized Feynman integral
Authors: Choi Jae
Published: March 2024

In this paper an analytic operator-valued generalized Feynman integral was
studied on a very general Wiener space Ca,b[0, T]. The general Wiener space
Ca,b[0, T] is a function space which is induced by the generalized Brownian
motion process associated with continuous functions a and b. The structure
of the analytic operator-valued generalized Feynman integral is suggested
and the existence of the analytic operator-valued generalized Feynman
integral is investigated as an operator from L1(R, ??,a) to L?(R) where ??,a
is a ?-finite measure on R given by d??,a = exp{?Var(a)u2}du, where ? > 0
and Var(a) denotes the total variation of the mean function a of the
generalized Brownian motion process. It turns out in this paper that the
analytic operator-valued generalized Feynman integrals of functionals
defined by the stochastic Fourier-Stieltjes transform of complex measures on
the infinite dimensional Hilbert space C?a,b[0, T] are elements of the
linear space ? ?>0 L(L1(R, ??,a), L?(R)).
SMB algebras I: On the variety of SMB algebras
Authors: Prokic Aleksandar , Djapic Petar , Markovic Petar , McKenzie Ralph
Published: March 2024

We begin the investigation of the variety of semilattices of Mal?cev blocks,
which we call SMB algebras.
Nonlinear bi-skew Jordan-type derivations on *-algebras
Authors: Zhao Fangfang , Zhang Dongfang , Li Changjing
Published: March 2024

Let A be a unital *-algebra. In this paper, under some mild conditions on A,
it is shown that ? is a nonlinear bi-skew Jordan-type derivations on A if
and only if ? is an additive *?derivation. As applications, the nonlinear
bi-skew Jordan-type derivations on prime *-algebras, von Neumann algebras
with no central summands of type I1, factor von Neumann algebras and
standard operator algebras are characterized.
A double phase equidiffusive logistic equation
Authors: Liu Zhenhai , Papageorgiou Nikolaos
Published: March 2024

We consider a (p, q)-equation with unbalanced growth (double phase problem)
and a logistic reaction of the equidiffusive type. We show the existence and
uniqueness of a positive solution.
Dynamics of predator-dependent nonlinear disease transmission in infected prey with diverse functional response
Authors: Ghosh Dipankar , Santra P.K. , Makinde O.D. , Mahapatra G.S.
Published: March 2024

The disease in prey causes the indirect effect on the disease transmission of
prey-predator interactions; this phenomenon of predator-dependent disease
transmission scenario can arise as a consequence of anti-predator defence
behaviour, debilitating the immune system of the prey. This concept is
implemented in the proposed nonlinear mathematical prey-predator model,
where an infectious disease infects only prey populations. The interaction
between the susceptible prey and predator is assumed to be governed by
Crowley-Martin type functional response and Holling I type functional
response for the predation of infected prey. The susceptible prey becomes
infected when contact occurs with the infected prey. The existence,
uniqueness, boundedness, and feasibility and stability conditions of the
fixed points of the system are analyzed. Hopf bifurcation analysis for the
system is perceived and presented through bifurcation diagrams for different
parameter values. Lastly, numerical exercises and graphical demonstrations
are given to help our investigative findings.
On π−nekrasov matrices
Authors: Arsic Dunja , Nedovic Maja
Published: March 2024

In this paper, we consider ??Nekrasov matrices, a generalization of {P1,
P2}?Nekrasov matrices obtained by introducing the set ? = {P1, P2, ..., Pm}
of m simultaneous permutations of rows and columns of the given matrix. For
point-wise and block ??Nekrasov matrices we give infinity norm bounds for
the inverse. For ??Nekrasov B?matrices, obtained through a special rank one
perturbation, we present main results on infinity norm bounds for the
inverse and error bounds for linear complementarity problems. Numerical
examples illustrate the benefits of new bounds.
Cumulative residual fisher information of a general k-th order autoregressive process
Authors: Kharazmi Omid , Balakrishnan Narayanaswamy
Published: March 2024

In this work, we consider cumulative residual Fisher information and
Bayes-cumulative residual Fisher information for a general k-th order
autoregressive and their corresponding stationary equilibrium distributions
and develop some associated results. We establish several interesting
connections between these measures and some known informational measures
such as chi-square divergence, Gini?s mean difference, cumulative residual
Kullback-Leibler, Jeffreys and Jensen-cumulative residual entropy
divergences.
Inhibition of HSP20 ameliorates steatotic liver disease by stimulating ERK2-dependent autophagy
Authors: Miao Yanli , Zhong Yi , Li Yutian , Qin Haojie , Yang Ling , Cao Guojun , Tang Yong , Yu Ting , Fan Di , Lu Yang , Peng Jiangtong , Huang Kai
Published: March 2024

Heat shock protein 20 (HSP20) emerges as a novel regulator of autophagy in the heart. Nonetheless, the detailed function of HSP20 in liver and its effect on autophagy remain unknown. Here, we observed that HSP20 expression is increased in liver tissues from mice and patients with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). Liver-specific downregulation of HSP20 mitigates hepatic steatosis and insulin resistance in obese mice, while upregulating HSP20 promotes lipid deposition and hepatocyte cell death. Mechanistically, Liquid chromatography tandem mass spectrometry (LC-MS/MS) revealed that HSP20 interacts with phosphorylated extracellular regulated protein kinases 2 (ERK2) and prevents its dephosphorylation by dual specificity phosphatase 6 (DUSP6), leading to ERK2-mediated repression of autophagy, resulting in aggravated saturated fatty acid (SFA)-triggered hepatocyte death. Importantly, such adverse effects could be ameliorated by ERK inhibitor. Our data reveals a framework of how HSP20 increases susceptibility of SFA-induced liver injury through enhancing ERK2 phosphorylation, which represents a plausible therapeutic intervention to combat MASLD.
In vitro evaluation of the effects of potential GSK-3β inhibitors terbutaline and orciprenaline
Authors: Uzunhisarcıklı Ebru
Published: March 2024

Lung cancer is a type of cancer that is mostly diagnosed at an advanced stage and has a short survival time despite standard chemotherapy and targeted therapies. Terbutaline and Orci-prenaline are bronchodilator agents that are potent and selective β2 receptor agonists. The purpose of this study was to investigate to evaluate the effects of Terbutaline and Orci-prenaline on A549 human lung carcinoma cell line and Beas-2b human bronchial epithelial cell line. Cells were treated with 1, 10, 100, 200, 400 µM concentrations of Terbutaline and Orciprenaline. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay and xCELLigence real-time cell analyzer were used to determine their effects on cell viability. The cell index was monitored continuously by visualizing the impedance of the E-plate wells. Because of the roles of Glycogen Synthase Kinase 3β (GSK3β) in a diverse range of cellular processes like metabolism, cell proliferation, differentiation and survival and its key position at several signaling pathways, GSK3β inhibition by Terbutaline and Orciprenaline was also investigated. The results showed that Terbutaline and Orciprenaline inhibits GSK-3β. The overall results led to the conclusion that Terbutaline and especially Orciprenaline may have potential therapeutic effects in lung carcinoma.
EFFORTS OF KKN STUDENTS TO MAKE THE MILLENNIAL GENERATION NATEH SMART, THROUGH CROSS-SECTORAL PROJECT SYNERGY
Authors: Fathullah Amal , Aulia Rachmah Najwa , Khairunisa Khairunisa , Izzati Hasna , Fadhli Ikhsan Abdullah Ibnu , Firdaus Hafiz , Subhannor Muhammad
Published: March 2024

Kuliah Kerja Nyata (KKN) is a concrete manifestation of the Tri Dharma of Higher Education in the form of research, education and community service. In this KKN, students can implement all the knowledge gained while in college, confront theory with the realities of community life and become partners with the government in building and educating village community education specifically. In the village of Nateh there are still many young people who decide to continue their studies in order to choose to work, and many children not optimal to study and attend school, the reason is the lack of love and attention from their parents. In addition, other influences are from the social environment of the community. Therefore, KKN students strive to build together the young generation of Nateh village who are smart, confident and Islamic, and able to face all waves of life. In order to be a useful generation for the nation through good education and provide examples or examples of how to behave properly.