bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic Dysfunction, Obesity, and Survival Among Patients With Early-Stage Colorectal Cancer
Authors: Cespedes Feliciano Elizabeth M. , Kroenke Candyce H. , Meyerhardt Jeffrey A. , Prado Carla M. , Bradshaw Patrick T. , Dannenberg Andrew J. , Kwan Marilyn L. , Xiao Jingjie , Quesenberry Charles , Weltzien Erin K. , Castillo Adrienne L. , Caan Bette J.
Published: September 2016

Purpose

The effects of obesity and metabolic dysregulation on cancer survival are inconsistent. To identify high-risk subgroups of obese patients and to examine the joint association of metabolic syndrome (MetSyn) in combination with obesity, we categorized patients with early-stage (I to III) colorectal cancer (CRC) into four metabolic categories defined by the presence of MetSyn and/or obesity and examined associations with survival.

Methods

We studied 2,446 patients diagnosed from 2006 to 2011 at Kaiser Permanente. We assumed MetSyn if patients had three or more of five components present at diagnosis: fasting glucose > 100 mg/dL or diabetes; elevated blood pressure (systolic ≥ 130 mm Hg, diastolic ≥ 85 mm Hg, or antihypertensives); HDL cholesterol < 40 mg/dL (men) or < 50 mg/dL (women); triglycerides ≥ 150 mg/dL or antilipids; and/or highest sex-specific quartile of visceral fat by computed tomography scan (in lieu of waist circumference). We then classified participants according to the presence (or absence) of MetSyn and obesity (BMI < 30 or ≥ 30 kg/m2) and assessed associations with overall and CRC-related survival using Cox proportional hazards models adjusted for demographic, tumor, and treatment factors and muscle mass at diagnosis.

Results

Over a median follow-up of 6 years, 601 patients died, 325 as a result of CRC. Mean (SD) age was 64 (11) years. Compared with the reference of nonobese patients without MetSyn (n = 1,225), for overall survival the hazard ratios (HR) and 95% CIs were 1.45 (1.12 to 1.82) for obese patients with MetSyn (n = 480); 1.09 (0.83 to 1.44) for the nonobese with MetSyn (n = 417), and 1.00 (0.80 to 1.26) for obese patients without MetSyn (n = 324). Obesity with MetSyn also predicted CRC-related survival: 1.49 (1.09 to 2.02). The hazard of death increased with the number of MetSyn components present, independent of obesity.

Conclusion

Patients with early-stage CRC with obesity and MetSyn have worse survival, overall and CRC related.
Prevalence of Differentiated Thyroid Cancer in Autopsy Studies Over Six Decades: A Meta-Analysis
Authors: Furuya-Kanamori Luis , Bell Katy J.L. , Clark Justin , Glasziou Paul , Doi Suhail A.R.
Published: September 2016

Purpose

Differentiated thyroid cancer (DTC) incidence has been reported to have increased three- to 15-fold in the past few decades. It is unclear whether this represents overdiagnosis or a true increase in incidence. Therefore, the current study aimed to estimate the prevalence of incidental DTC in published autopsy series and determine whether this prevalence has been increasing over time.

Materials and Methods

PubMed, Embase, and Web of Science were searched from inception to December 2015 for relevant studies. Two authors searched for all autopsy studies that had included patients with no known history of thyroid pathology and reported the prevalence of incidental DTC (iDTC). Two authors independently extracted the data, and discrepancies were resolved by another author. The pooled prevalence of iDTC was assessed using a fixed-effects meta-analysis model with robust error variance. The time effect was studied using an inverse-variance weighted logit-linear regression model with robust error variance and a time variable.

Results

Thirty-five studies, conducted between 1949 and 2007, met the inclusion criteria and contributed 42 data sets and 12,834 autopsies. The prevalence of iDTC among the partial and whole examination subgroups was 4.1% (95% CI, 3.0% to 5.4%) and 11.2% (95% CI, 6.7% to 16.1%), respectively. Once the intensiveness of thyroid examination was accounted for in the regression model, the prevalence odds ratio stabilized from 1970 onward, and no time effect was observed.

Conclusion

The current study confirms that iDTC is common, but the observed increasing incidence is not mirrored by prevalence within autopsy studies and, therefore, is unlikely to reflect a true population-level increase in tumorigenesis. This strongly suggests that the current increasing incidence of iDTC most likely reflects diagnostic detection increasing over time.
Teamwork and Electronic Health Record Implementation: A Case Study of Preserving Effective Communication and Mutual Trust in a Changing Environment
Authors: Gross Anne H. , Leib Ryan K. , Tonachel Anne , Tonachel Richard , Bowers Danielle M. , Burnard Rachel A. , Rhinehart Catherine A. , Valentim Rahila , Bunnell Craig A.
Published: September 2016

This article describes how trust among team members and in the technology supporting them was eroded during implementation of an electronic health record (EHR) in an adult outpatient oncology practice at a comprehensive cancer center. Delays in care of a 38-year-old woman with high-risk breast cancer occurred because of ineffective team communication and are illustrated in a case study. The case explores how the patient’s trust and mutual trust between team members were disrupted because of inaccurate assumptions about the functionality of the EHR’s communication tool, resultant miscommunications between team members and the patient, and the eventual recognition that care was not being effectively coordinated, as it had been previously. Despite a well-established, team-based culture and significant preparation for the EHR implementation, the challenges that occurred point to underlying human and system failures from which other organizations going through a similar process may learn. Through an analysis and evaluation of events that transpired before and during the EHR rollout, suggested interventions for preventing this experience are offered, which include: a thorough crosswalk between old and new communication mechanisms before implementation; understanding and mitigation of gaps in the communication tool’s functionality; more robust training for staff, clinicians, and patients; greater consideration given to the pace of change expected of individuals; and development of models of collaboration between EHR users and vendors in developing products that support high-quality, team-based care in the oncology setting. These interventions are transferable to any organizational or system change that threatens mutual trust and effective communication.
Dynamic Signaling with Dropout Risk
Authors: Dilmé Francesc , Li Fei
Published: September 2016

We study the role of dropout risk in dynamic signaling. A seller privately knows the quality of an indivisible good and decides when to trade. In each period, he may draw a dropout shock that forces him to trade immediately. To avoid costly delay, the seller with a low-quality good voluntarily pools with early dropouts, implying that the expected quality of the good increases over time. We characterize the time-varying equilibrium trading dynamics. It is demonstrated that the maximum equilibrium delay of trade is decreasing in the initial belief that the good is of high quality. (JEL C73, D82, D83)
Don't Demotivate, Discriminate
Authors: Kamphorst Jurjen J. A. , Swank Otto H.
Published: September 2016

This paper offers a new theory of discrimination in the workplace. We consider a manager who has to assign two tasks to two employees. The manager has superior information about the employees' abilities. We show that besides an equilibrium where the manager does not discriminate, equilibria exist where the manager discriminates in favor of the employee whom the employees expect to be favored. The manager, who has no taste for discrimination, discriminates in order to avoid demotivating the “favorite.” We show that the nondiscriminatory equilibrium is unstable. Yet the manager would prefer to commit not to discriminate. (JEL D82, D84, J71, M12, M51, M54)
A Contribution to the Empirics of Reservation Wages
Authors: Krueger Alan B. , Mueller Andreas I.
Published: September 2016

This paper provides evidence on the behavior of reservation wages over the spell of unemployment, using high-frequency longitudinal data on unemployed workers in New Jersey. In comparison to a calibrated job search model, the reservation wage starts out too high and declines too slowly, on average, suggesting that many workers persistently misjudge their prospects or anchor their reservation wage on their previous wage. The longitudinal nature of the data also allows for testing the relationship between job acceptance and the reservation wage, where the reservation wage is measured from a previous interview to avoid bias due to cognitive dissonance. (JEL J22, J31, J64)
Leaving Poverty Behind? The Effects of Generous Income Support Paired with Activation
Authors: Markussen Simen , Røed Knut
Published: September 2016

We evaluate a comprehensive activation program in Norway targeted at hard-to-employ social assistance claimants with reduced work capacity. The program offers a combination of tailored rehabilitation, training, and job practice, and a generous, stable, and non-means-tested benefit. Its primary aims are to mitigate poverty and subsequently promote self-supporting employment. Our evaluation strategy exploits a geographically staggered program introduction, and the causal effects are identified on the basis of changes in employment prospects that coincide with local program implementation in a way that correlates with the predicted probability of becoming a participant. We find that the program raised employment prospects considerably. (JEL H55, I32, I38, J24)
FORMALIZING PORTER´S CONCEPTION AND MENTALLY EXPERIMENTATION BY ADAM SMITH
Authors: Тарасенко  , Tarasenko Vladislav
Published: September 2016

This paper proposes a novel approach to formalization of the concept of cluster, proposed by Michael Porter and the general structuring of transaction costs of companies - potential participants in the cluster. Analyzes the thought experiment of Adam Smith´s pin with the production in terms of outsourcing companies - cluster members.
ATIVIDADE FÍSICA E SAÚDE: DA CONCEPÇÃO AO ENVELHECIMENTO
Authors: Hallal Pedro Curi
Published: September 2016

EDITORIAL
GAIT VELOCITY AND STEP LENGTH MAY DISCRIMINATE ACTIVE FROM SEDENTARY ELDERLY WOMEN
Authors: Moreira Bruno De Souza , Kirkwood Renata Noce , Lopes Andréa De Jesus , Dias Rosângela Corrêa , Sampaio Rosana Ferreira
Published: September 2016

Gait is an important functional activity that elderly individuals used to stay active and be ableto perform their daily living tasks. The purpose of this study was to determine what gait parameterscould discriminate a group of community-dwelling elderly women regularly enrolledin a physical exercise program compared to a paired sedentary group. Participated 145women (65 to 83 years) separated into two groups based on the guidelines of the AmericanCollege of Sports Medicine (2007): sedentary (n = 52) and active (n = 93). Eight gait variableswere recorded using the GAITRite® system (velocity normalized by length of lower limbs, stancetime, swing time, double support time, step time, step length, base width and cadence).Factorial analysis followed by discriminant analysis was performed to determine which variablescould best discriminate the sedentary group from the active group. Factorial analysisresulted in 4 factors which explained 98.7% of the data variability. Factor 3 (composed of steplength and velocity) explained 11.8% of the data variability and was the only factor to discriminatethe groups. When the original variables from Factor 3 were analyzed, gait velocity wasthe most discriminant variable, with a much higher discriminant coeffi cient (-0.999) than steplength (-0.022). Gait velocity and step length could be used as a screening tool to discriminatebetween active and sedentary elderly women.
PRÁTICA DE ATIVIDADE FÍSICA EM QUATRO DOMÍNIOS EM IDOSOS COM HIPERTENSÃO ARTERIAL REFERIDA NO MUNICÍPIO DE SÃO PAULO: ESTUDO DE BASE POPULACIONAL
Authors: Massa Kaio Henrique Correa , Guimarães Vanessa Valente , César Chester Luiz Galvão , Barros Marilisa Berti de Azevedo , Carandina Luana , Goldbaum Moisés , Florindo Alex Antonio
Published: September 2016

A prática de atividade física (AF), no contexto de prevenção de doenças crônicas não-transmissíveis,é uma indicação de tratamento não-medicamentoso crescente, principalmenterelacionada a patologias como a hipertensão arterial sistêmica (HAS), doença de alta prevalênciapopulacional que caracteriza um dos principais fatores de risco para as doenças cardiovascularese cerebrovasculares, maiores causas de mortalidade mundiais na modernidade.Avaliar a prática de AF em quatro domínios em população de 60 anos ou mais que referiuHAS segundo as características sociodemográfi cas. Este trabalho decorre do Inquérito deSaúde no Município de São Paulo, ISA-Capital 2003, estudo transversal de base populacional,com dados coletados por entrevista domiciliar. Investigou-se a prática de AF em quatro domíniosatravés do IPAQ versão longa. Utilizou-se análise de Regressão de Poisson para modelosmultivariados. A amostra do estudo totalizou 395 idosos, portadores autorreferidos de HAS.Observou-se 6,2% de ativos na prática de AF no trabalho, 16,9% na locomoção, 41,4% na domésticae 19,6% no lazer. A prática de AF no trabalho teve associação com sexo masculino emenor faixa etária; na locomoção não apresentou associação signifi cativa com as variáveisestudadas; na doméstica observou-se associação com sexo feminino, menor faixa etária e situaçãoconjugal de viuvez; e no lazer houve associação com maior escolaridade. Observou-sediferentes associações entre a prática recomendada de AF, nos quatro domínios, e variáveissociodemográfi cas na população idosa com HAS autorreferida no Município de São Paulo. Nogeral, a prática de atividade física foi baixa devendo ser estimulada nessa população.
RELAÇÃO ENTRE FREQUÊNCIA CARDÍACA E LACTATO DURANTE A GINÁSTICA AERÓBICA DE BAIXO IMPACTO E O STEP
Authors: Romero Andrea Christofoletti , Denadai Benedito Sergio
Published: September 2016

O objetivo deste estudo foi descrever e com­parar a relação entre frequência cardíaca (FC) e lactato sanguíneo (LAC) de três diferentes moda­lidades de ginástica: a) ginástica aeróbica de bai­xo impacto e baixa intensidade (BIBI); b) ginásti­ca aeróbica de baixo impacto e alta intensidade (BIAI) e c) Step. Participaram do estudo 7 indiví­duos do sexo feminino (X= 22,5 ± 2,2 anos), frequentadoras de uma academia na cidade de Rio Claro. A coreografia dos três tipos de aula não apresentou saltitos (sem fase de vôo) e os movi­mentos dos membros inferiores e superiores não ultrapassaram respectivamente, a altura do quadril e dos ombros. As aulas de BIBI e Step foram fei­tas com músicas que apresentavam 128 batidas/ minuto e a de BIAI com 144 batidas/minuto. Os três tipos de aula apresentaram a mesma sequência e duração: aquecimento (5 min), parte aeróbia (30 min) e resfriamento (10 min), sendo que as coletas de FC e LAC foram feitas após 15 e 30 min do início da parte aeróbia. Os sujeitos realizaram tam­bém 3 tiros de 1200 m para a determinação da FC correspondente ao limiar aeróbio e anaeróbio (res­pectivamente 2 mM e 4 mM de lactato). A FC (bat/ min) e a % FCmax obtidas durante a BIBI (150,29 ± 9,98 e 75,5 ± 4.0) foram menores do que os res­pectivos valores atingidos durante as aulas de BIAI (164,4 ± 9,56 e 82,5 ± 7,45), Step (165 ± 7,98 e 82,2 ± 7,45), no limiar aeróbio (167,83 ± 9,22 e 84,0 ± 4,58) e anaeróbio (185,33 ± 8,64 e 88,6 ± 6,21). Não foram encontradas diferenças entre os valores do BIAI, Step e limiar aeróbio. O lactato (mM) não foi diferente ente entre as três modali­dades (BIBI = 0,93 ± 0,27 ; BIAI = 1,02 ± 0,22 e Step = 1,05 ± 0,15 mmol/l). Estes resultados suge­rem que a relação entre FC e LAC nas aulas estu­dadas é diferente do que a relação obtida durante a corrida. Deste modo, não parece adequado afirmar que um programa de treinamento de ginástica aeróbica de baixo-impacto ou Step produz adapta­ções cardiovasculares e metabólicas semelhantes a um treinamento de corrida que utilize a mesma FC alvo.
Puzzle—Verbal Arithmetic and Mastermind
Authors: Simon John T.
Published: September 2016

Verbal arithmetic (also known as cryptarithmetic) problems and a numerical version of the game Mastermind are both solvable as integer programs. This article describes these puzzles and develops an integer programming model and an Excel based implementation for each of them.
Market Mechanisms in Online Peer-to-Peer Lending
Authors: Wei Zaiyan , Lin Mingfeng
Published: September 2016

Online peer-to-peer lending (P2P lending) has emerged as an appealing new channel of financing in recent years. A fundamental but largely unanswered question in this nascent industry is the choice of market mechanisms, i.e., how the supply and demand of funds are matched, and the terms (price) at which transactions will occur. Two of the most popular mechanisms are auctions (where the “crowd” determines the price of the transaction through an auction process) and posted prices (where the platform determines the price). While P2P lending platforms typically use one or the other, there is little systematic research on the implications of such choices for market participants, transaction outcomes, and social welfare. We address this question both theoretically and empirically. We first develop a game-theoretic model that yields empirically testable hypotheses, taking into account the incentive of the platform. We then test these hypotheses by exploiting a regime change from auctions to posted prices on one of the largest P2P lending platforms. Consistent with our hypotheses, we find that under platform-mandated posted prices, loans are funded with higher probability, but the preset interest rates are higher than borrowers’ starting interest rates and contract interest rates in auctions. More important, all else equal, loans funded under posted prices are more likely to default, thereby undermining lenders’ returns on investment and their surplus. Although platform-mandated posted prices may be faster in originating loans, auctions that rely on the crowd to discover prices are not necessarily inferior in terms of overall social welfare.

This paper was accepted by Chris Forman, information systems.
On the Measurement of Economic Tail Risk
Authors: Kou Steven , Peng Xianhua
Published: September 2016

This paper attempts to provide a decision-theoretic foundation for the measurement of economic tail risk, which is not only closely related to utility theory but also relevant to statistical model uncertainty. The main result is that the only risk measures that satisfy a set of economic axioms for the Choquet expected utility and the statistical property of general elicitability (i.e., there exists an objective function such that minimizing the expected objective function yields the risk measure) are the mean functional and value-at-risk (VaR), in particular the median shortfall, which is the median of tail loss distribution and is also the VaR at a higher confidence level. We also discuss various approaches of backtesting and their relations to elicitability and co-elicitability; in particular, we show that the co-elicitability of VaR and expected shortfall does not lead to a reliable backtesting method for expected shortfall and there have been only indirect backtesting methods for expected shortfall. Furthermore, we extend the result to address model uncertainty by incorporating multiple scenarios. As an application, we argue that median shortfall is a better alternative than expected shortfall for setting capital requirements in Basel Accords.
ECG of the month
Authors: Regan Martin
Published: September 2016

Martin Regan presents an ECG for you to analyse
New potential cardiovascular disease treatment
Authors: Jane Palmer Sarah
Published: September 2016

This section presents a concise overview of the conditions, treatments and clinical procedures in the field of cardiovascular care. This ‘back-to-basics’ article aims to refresh nurses' knowledge on correct theory and practice, as well as introduce students and junior nurses to aspects of practice
SGLT2i: A novel approach to managing type 2 diabetes
Authors: Meetoo Danny D , Wong Louise , Allouzi Lina
Published: September 2016

Sodium glucose cotransporter type 2 inhibitors (SGLT2i), specifically canagliflozin, dapagliflozin and empagliflozin, are a novel group of drugs developed to treat type 2 diabetes mellitus (T2DM). They act by reducing renal glucose reabsorption and promoting urinary glucose excretion, thereby preventing hyperglycaemia in people with T2DM. While all three drugs have UK marketing authorisations and National Institute of Health and Care Excellence approval for their use to improve glycaemic control in people with T2DM, it is nevertheless important for clinicians to give serious consideration to their therapeutic efficacy when funding is discussed with commissioners.
SATs: The aftermath
Authors: O'Connell Suzanne
Published: September 2016

The 2016 SATs might be behind us, but headteachers are still angry about what the majority see as having been a testing fiasco. With a new school year beginning, heads reflect and speculate about what should happen in 2017
Achieving outstanding early years provision
Authors: O'Connell Suzanne
Published: September 2016

By the time the children at Eastfield Primary Academy leave Reception they are well prepared for year 1. However, the children enter the nursery school below their expected level of development. So, how does the school achieve this level of progress? Suzanne O'Connell found out
Find the perfect SENCO
Authors: Sobel Daniel
Published: September 2016

Schools are finding it hard to recruit successful SENCOs. Daniel Sobel believes this is down to the changing requirements of this broad and vital position. He looks at the modern SENCO role and advises on recruiting effectively
Teaching pupils with sensory difficulties
Authors: Symons Kristina
Published: September 2016

Teaching children with autism sensory difficulties can provide specific challenges for classroom teachers. Kristina Symons breaks down some of the most common challenges for pupils with autism and offers her advice
Is your school on track for coaching gold?
Authors: Holland Michael
Published: September 2016

Hot on the heels of coaching successes at the Rio Olympics, Michael Holland explores how schools can embed an effective coaching culture
Post-transplant non-adherence of immunosuppression in a transplant outpatient group
Authors: Russell Sheila , Van Dellen David
Published: September 2016

Patients who have received transplanted organs need to take lifelong immunosuppressive therapy to maintain their grafts. Non-adherence to this medication in renal transplant patients is associated with an increased risk of graft failure and a return to dialysis, as well as the need for another organ transplant. The purpose of this study was to identify the prevalence of non-adherence to immunosuppressive therapy in a group of post-renal transplant outpatients. A group of 500 post-transplant outpatients were enrolled. The Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) was used to assess the prevalence of non-adherence in patients who were at least 1 year post transplant. Patients identified as non-adherent by the BAASIS questionnaire were asked to complete the Identifying Medication Adherence Barriers (IMAB) questionnaire to investigate further the reasons for non-adherence.
Morfometrik lima species ikan yang dominan tertangkap di Danau Aneuk Laot, Kota Sabang
Authors: Khayra Auliyanisa , A. Muchlisin Zainal , A. Sarong Muhammad
Published: September 2016

Abstract. The objective of the present study was to analyze the morphometric variationsof five predominant fish species caught in Lake Aneuk Laot, Sabang City,Weh Island.The study was conducted in December 2015 to January 2016. The survey method was used in this study. The fish target were Nile tilapia (Oreochromis niloticus), tilapia (O. mossambicus), snakeskin gourami (Trichopodus pectoralis), giant gourami (Osphronemus goramy) and snakehead (Channa striata). The fish samples were catched using gillnets. The fish sample were analyzed for traditional and truss network morphometrics. The results showed that there is closed morphological relationship between Nile tilapia and tilapia, and between snakeskin gourami and giant gourami, while the snakehead fish was discriminated apart from the two previous groups.Keywords: Morphometric Nile tilapia, tilapia, snakeskin gourami, giant gourami, snakehead fish, Weh Island Abstrak. Penelitian ini bertujuan untuk menganalisis variasi morfologi ikan hasil tangkapan dominan di Danau Aneuk Laot Kota Sabang dengan menggunakan teknik traditional dan truss morphometric. Penelitian dilakukan pada Desember 2015 sampai Januari 2016. Ikan sampel terdiri dari ikan nila (Oreochromis niloticus), ikan mujair (O. mossambicus), ikan sepat siam (Trichopodus pectoralis), ikan gurami (Osphronemus gorami) dan ikan gabus (Channa striata). Ikan sampel diperoleh dengan menggunakan alat tangkap jaring. Sebanyak 12 karakter traditional morphometric and 14 karakter truss dianalisis dalam penelitian ini.  Hasil penelitian menunjukkan terdapat tiga kelompok ikan, kelompok pertama ikan nila dan ikan mujair, kedua ikan ini kemiripan yang tinggi; kelompok kedua adalah ikan sepat siam dan ikan gurami, kelompok ketiga adalah ikan gabus yang memiliki kemiripan yang jauh dengan kedua kelompok ikan sebelumnya.Kata kunci: Morfometrik, Nila, mujair, sepat siam, gurami, gabus, Pulau Weh
Morfometri Danau Kelapa Gading Kota Kisaran, Kabupaten Asahan Provinsi Sumatera Utara
Authors: Ridoan Rizki , Muhtadi Ahmad , Patana Pindi
Published: September 2016

Abstract. Kelapa Gading Lake is an artificial lake located in Asahan of North Sumatera. Data on the lake morphometry is needed to determin the level of water fertility, and to know ability of lake in accepting the pollutant load. The purpose of the study was to examine aspects of the lake morphometry. The research was conducted from February to April 2016. Data collected in this research were depth, water flow, the width of the lake and around the lake. The data were processed using ArcMap. The result showed that Kelapa Gading Lake has an area approximately 11931.37 m2, with the maximum length of 161.14 m, a the maximum width of 124.72 m, and the circumference of 688.50 m. The maximum depth of 2.15 m, with the shape of the lake bottom is flat. The water volume is approximately  15033.52 m3, and the water discharge of about 0.74 to 0.92 L s-1, with a stay of lake water ± 225-226 days, the brightness of the water ranges from 0.37 to 0.48 m with the compensation depth of about  0.98 to 1.07 m, and Kelapa Gading Lake has low stability.Keywords: ArcMap, bathymetric, compensation depth, lake, morphometry Abstrak. Danau Kelapa Gading merupakan danau buatan yang berada di Kabupaten Asahan, Sumatera Utara. Data mengenai morfometri danau sangat diperlukan untuk menentukan tingkat kesuburan perairan dan juga mengetahui seberapa besar kemampuan danau dalam menerima beban pencemar. Tujuan dari penelitian ini untuk mengetahui aspek morfometri danau Kelapa Gading. Penelitian ini dilaksanakan dari Februari-April 2016. Pengambilan  data yang dilakukan dalam penelitian ini adalah data kedalaman, debit air, lebar danau, dan keliling danau. Data-data tersebut diolah dengan menggunakan ArcMap. Hasil penelitian menunjukkan bahwa Danau Kelapa Gading memiliki luas sekitar 11.931,37 m2, dengan panjang maksimum 161,14 m, lebar maksimum 124,72 m, keliling 688,50 m. Kedalaman maksimum 2,15 m, dengan bentuk dasar danau rata. Volume Danau Kelapa Gading adalah 15.033,52 m3, debit air sekitar 0,74-0,92 L/s, dengan masa tinggal air danau ±225-226 hari, kecerahan air berkisar 0,37-0,48 m dengan kedalaman kompensasi sekitar 0,98-1,15 m, dan Danau Kelapa Gading memiliki stabilitas yang rendah dan akan mudah mengalami pengadukan.Kata kunci: ArcMap, batimetri, danau, kedalaman kompensasi, morfometri
El papel de la gestión del director escolar en el programa Mi Compu.Mx
Authors: Glasserman Morales Leonardo David , Gavotto Nogales Omar Iván , Ramírez Montalvo Nélida Aurea
Published: September 2016

El presente estudio forma parte de un macro proyecto de investigación, el cual busca identificar las competencias digitales desarrolladas por los alumnos y los docentes que participan en el Programa Mi Compu.Mx en los estados de Tabasco, Colima y Sonora, en México. En este artículo se reporta la experiencia de la implementación del programa Mi Compu.Mx en el estado de Sonora, desde la perspectiva del director escolar y la gestión llevada a cabo en este proceso de innovación educativa. El objetivo del estudio fue identificar el papel de la gestión del director escolar en la implementación de un programa de innovación, en el contexto del estado de Sonora, México. La pregunta de investigación fue: ¿Cuál es la participación del director escolar en la implementación del programa Mi Compu.Mx en las escuelas primarias del estado de Sonora, México? Se siguió una metodología cualitativa con un enfoque de estudio de casos en donde realizaron entrevistas a 114 directores de nivel primaria. Entre los hallazgos principales, se encontró que el director participa como el gestor de los recursos materiales para cumplir con la autonomía de la gestión escolar y es el actor imprescindible para garantizar las condiciones necesarias para un pleno funcionamiento de proyectos de innovación con tecnología en el aula.
Association of HLA class II and history of atopy and frequent relapse of childhood steroid-sensitive nephrotic syndrome
Authors: Hilmanto Dany
Published: September 2016

Background The association between HLA class II and frequentrelapse of nephrotic syndrome (FRNS) has been reported.Objective To identify the association between HLA class II,history of atopy, and upper respiratory tract infection (URTI)with FRNS.Methods This was a case control study conducted at theDepartment of Child Health, Hasan Sadikin Hospital Bandungand Cipto Mangunkusumo Hospital Jakarta from November 2002to October 2003 on children aged 1-14 years with FRNS. Thesubjects consisted of 40 FRNS and 84 healthy children. HLAclass II was typed by polymerase chain reaction-sequence specificoligonucleotide (PCR-SSO) in Leiden, the Netherlands. Theassociation between HLA class II and FRNS was expressed byodds ratio (OR). The association between such factors and FRNSwas analyzed by logistic regression.Results Atopy was higher in patients than that in controls(P=0.013). URTI did not differ in both groups (P=0.173). HLA-DRB1*03 and DRB1*04 (OR=4.43, P=0.03), DQB1*02(OR=3.43, P=0.00), and DQB1*04 (OR=12.06, P=0.01) weresignificantly higher among patients than those in controls whereasHLA-DRB1*12 (OR=0.34, P=0.02) and DQB1*0301p(OR=0.35, P=0.02) were significantly lower among patients thanthose in controls. Using logistic regression analysis, only HLA-DRB1*12, DQB1*02 and atopy took part in FRNS.Conclusion HLA-DRB1*12, DQB1*02, and atopy all togetherhave association with FRNS.
Agreement of simplified Fencl-Stewart with Figge-Stewart method in diagnosing metabolic acidosis in critically ill children
Authors: Sinaga Rotua , Sukadi Abdurachman , Somasetia Dadang Hudaya
Published: September 2016

Background The traditional Henderson-Hasselbalch approach hasproven to be imprecise in critically ill patients. Stewart’s approachcan detect metabolic acidosis missed by traditional approach,including acidosis caused by increased unmeasured agreement(UA). The complexity of Stewart’s method leads to developmentof simpler modifications, simplified Fencl-Stewart and Figge-Stewart method. Agreement between both modifications isunknown.Objective This study aimed to measure the agreement of simplifiedFencl-Stewart with Figge-Stewart method in diagnosing metabolicacidosis in critically ill children.Methods The was performed in Hasan Sadikin General Hospital,Bandung from July to August 2006, involving <14 year-old criticallyill children. Blood samples for gas analysis, sodium, potassium,chloride and albumin measurement were taken simultaneously. Testresult was analyzed with simplified Fencl-Stewart and Figge-Stewartmethod and recorded with Excell spreadsheet. PASS was used forinterim analysis and DAG_Stat for raw agreement indices andKappa calculations.Results Forty-five (31 males, 14 females) children were enrolled.Acid base disturbances based on Stewart’s method were identifiedin 10 subjects with normal base excess and nine with normalbicarbonate. Significant increase of UA was detected in 11 of 45subjects with simplified Fencl-Stewart method, compared to thatof 12 subjects with Figge-Stewart method. Raw agreement indicesshowed 95.65% and 98.51% agreement for positive and negativeresult, Kappa was 0.94 (P=0.0000).Conclusions Excellent agreement is shown between simplifiedFencl-Stewart and Figge-Stewart method in diagnosing metabolicacidosis in critically ill children. Increased UA can be assessedwith both methods.
Suicídio: uma análise da última comunicação
Authors: Araújo Gemailson Nogueira de , Oliveira Gislene Farias de
Published: September 2016

Este artigo, discute o suicídio como a ultima escolha do ser humano e, como uma última comunicação,  trata de uma análise deste fenômeno no contexto da filosofia e da psicologia na visão de Freud. Mas busca-se, sobretudo, entender os motivos que levam a um individuo a suicidar-se relacionando o suicídio ao processo psicossocial. Assim, diante da hipótese podemos perceber que é um problema atual e pouco estudado na região do Cariri. Trata-se de um estudo bibliográfico como método de interpretação do fenômeno. O objetivo é conhecer a mensagem, na qual o corpo deixa de ser fundamental ao indivíduo. Tanto essa discussão quanto o processo psicossocial humano serão abordados também principalmente, através da visão psicanalítica de Cassorla, 2003.
REPRESENTASI IDEOLOGI DAN KEKUASAAN DALAM BAHASA: KAJIAN TEKS MEDIA
Authors: Suharyo Suharyo , Surono Surono , Amin Mujid F
Published: September 2016

This article is based on the assumption that language is not in a social vacuum. Language is more than a set of words that merely linguistic, but also social. Therefore, the current linguistic research should take into account the social dimension in the analysis are critical, such as van Dijk’s critical discourse analysis (CDA) research model. The critical discourse analysis research  considering the text, context, social cognition, and analysis/social context. Research steps include: exposing the macro structure (thematic), superstructure (schematic), and microstructure consisting of semantics, syntax, stylistic, and rhetoric. Accordingly, this study uses the method read and record while research data has been collected from Suara Merdeka and Kompas newspaper. Finally concluded that the language represents the ideology and power (symbolic) both individual and communal.
Synthesis and Antidepressant activity of pyrazoline based MAO-inhibitors
Authors: Badavath Vishnu Nayak , Kumar Alok , Jadav Surender Singh , Pattnaik Ashok Kumar , Jayaprakash Venkatesan , Sinha Barij Nayan
Published: September 2016

A series of nine 3-(2-hydroxyphenyl)-5-aryl-N-phenyl-4,5-dihydropyrazole-1-carbothioamide derivative s (3a-3i) that were earlier reported as potent rMAO-A inhibitors were evaluated for their antidepressant activity in Porsolt's behavioral despair test (forced swim test) and Tail Suspension test activity, among them, compounds (3eÂ andÂ 3h) were found to have potent antidepressant activity. Reduction in duration of immobility was significant for all the compounds in Porsolts swim test compared with tail suspension test. 3h was further evaluated for anxiolytic activity in Elevated plus maze and was found to be devoid of it.
Static Method to Determine Compaction Characteristics of Fine-Grained Soils
Authors: Sharma B. , Sridharan A. , Talukdar P.
Published: September 2016

Engineering projects such as roads, earthen dams, embankments, and trench backfills require soil compacted at higher dry unit weight. In a majority of geotechnical projects, compaction of soils is involved with increasing strength and decreasing compressibility and permeability. The Proctor compaction test forms one of the most popular and important tests in geotechnical engineering practice. The moisture content-dry unit weight relationship of the soil obtained from the standard Proctor test forms the basis for specification and field compaction control. Standard Proctor test, also known as the dynamic compaction test requires considerable time and effort and has few imperfections. This study examined the possibility of determining the equivalent static pressure to the standard Proctor test to obtain the optimum moisture content, OMC, and maximum dry unit weight, of fine-grained soils. For this, a static compaction pressure test was devised in the Proctor mold itself to statically compact the soil at different water contents. The equivalent static pressure so determined will simplify the compaction procedure and will also result in considerable saving of time, money, and effort, especially so when dealing with highway and earth embankment projects.
Closure to “Discussion of ‘Measurement of Stiffness Anisotropy in Kaolinite Using Bender Element Tests in a Floating Wall Consolidometer’ by X. Kang, G.-C. Kang, and B. Bate” by Coffman, Salazar and Zhao
Authors: Kang X. , Kang G.-C. , Bate B.
Published: September 2016

The authors appreciate the interest of the discussers in this paper. The main arguments of the discussers were: (1) comparing the back-pressure saturated, constant-rate-of-strain consolidation device that incorporated bender elements (BP-CRS-BE device) developed by the discussers to the floating wall consolidometer based bender element testing system in the original paper (Kang, X., Kang, G.-C., and Bate, B., 2014, “Shear Wave Velocity Anisotropy of Kaolinite Using a Floating Wall Consolidometer-Type Bender Element Testing System,” Geotech. Test. J., Vol. 37, No. 5, pp. 869–883. [DOI: 10.1520/GTJ20120205]); (2) requesting the quantification of both the system lag and the machine deflection; (3) suggesting the authors use cross correlation method to determine the first arrival time because Vs values obtained by time domain method are “only approximate,” while the latter was the only method used by the discussers in their referenced work (Salazar, S. E. and Coffman, R. A., 2014, “Design and Fabrication of End Platens for Acquisition of Small-Strain Piezoelectric Measurements during Large-Strain Triaxial Extension and Triaxial Compression Testing,” Geotech. Test. J., Vol. 43, No. 2. pp. 1–11. [DOI: 10.1520/GTJ20140057]); and (4) making misleading arguments regarding the compression and shear waves measurements. In this closure, the authors first briefly compared the BP-CRS-BE device to the floating wall consolidometer based bender element testing system, and pointed out that (1) the well-documented wavelength ratio (Rd ratio) consideration in designing a bender element device and the seemingly unsatisfaction of such consideration in the BP-CRS-BE device, and that (2) both the lack of details in B-value checking to examine saturation and the lack of shear wave velocity resulted from the BP-CRS-BE device to substantiate the arguments of the discussers. Then the authors provided the requested quantifications of both system lag and machine deflection to address some postulations by the discussers. The authors disagreed with Arguments 3 and 4 made by the discussers, and respond accordingly.
Comparative Impact Behavior of High-C Steel After Conventional Quenching, Tempering, and Austempering
Authors: Vatavuk J. , Totten G. E. , Nucci J. E. , Albano L. L. M. , Canale L. d. C. F.
Published: September 2016

Usually bainitic microstructures exhibit good toughness and austempering is typically the preferred heat treatment when toughness is the primary requirement of the component. Several reports have shown such characteristics when compared to tempered martensite. High-carbon steel may exhibit brittle characteristics but it is a good steel with respect to mechanical properties and wear resistance. The objective of this study was to compare the impact properties of AISI O1, a high-carbon tool steel, designated VND in Brazil. This was done by comparing Charpy impact strength under different heat-treatment cycles. Steel test specimens were quenched from 820°C and tempered at 450°C to obtain tempered martensite, then austenitized, cooled, and held at 350°C to obtain bainite by holding at temperature for 20, 40, and 60 min. Because hardness influences impact behavior, comparative studies were performed at the same surface hardness level. The austempered samples with bainite microstructures obtained at a constant temperature and, by varying holding times, exhibited lower impact properties as compared to the quenched and tempered condition.
Structure and Properties of Duplex Layers Composed of Chromium and Titanium Carbides
Authors: Kasprzycka E. , Tacikowski J. , Bogdanski B.
Published: September 2016

The structures and properties of the CrC-TiC type duplex layers with an intermediate chromium carbide sublayer and an outer one of titanium carbide, as well as of the TiC-CrC type layers with an intermediate titanium carbide sublayer and an outer one of chromium carbide, produced on steels, were investigated. The structure of the duplex layers produced on plain carbon and alloy steel was compared with the single layers. The microstructure and chemical composition of these layers was determined by means of optical and transmission electron microscopy and X-ray phase analysis. A spectral linear analysis of the Cr, Fe, and Ti concentration in the diffusion zone was performed by means of an X-ray microanalyzer. Proof was presented that the thickness of the outer TiC layer depends on the thickness of the intermediate chromium carbide sublayer. This sublayer slows down the formation of the outer TiC layer. The structure of the chromium carbide sublayer undergoes changes during the process formation of the titanium carbide layer. The hardness and tribological properties of the layers have been determined. A comparison of CrC-TiC and TiC-CrC duplex layers with the CrC and TiC single carbide layers was performed. It was shown that the tribological properties of the CrC-TiC duplex layers are better than those of the TiC-CrC duplex layers, and those of the CrC and TiC type single carbide layers.
Pueraria mirifica alleviates cortical bone loss in naturally menopausal monkeys
Authors: Kittivanichkul Donlaporn , Charoenphandhu Narattaphol , Khemawoot Phisit , Malaivijitnond Suchinda
Published: September 2016

Since the in vitro and in vivo anti-osteoporotic effects of Pueraria mirifica (PM) in rodents have been verified, its activity in menopausal monkeys was evaluated as required before it can be applicable for human use. In this study, postmenopausal osteoporotic monkeys were divided into two groups (five per group), and fed daily with standard diet alone (PMP0 group) or diet mixed with 1000 mg/kg body weight (BW) of PM powder (PMP1000 group) for 16 months. Every 2 months, the bone mineral density (BMD), bone mineral content (BMC) and bone geometry parameters (cortical area and thickness and periosteal and endosteal circumference) at the distal radius and proximal tibia were determined using peripheral quantitative computed tomography together with plasma and urinary bone markers. Compared with the baseline (month 0) values, the cortical, but not trabecular, BMDs and BMCs and the cortical area and thickness at the metaphysis and diaphysis of the radius and tibia of the PMP0 group continuously decreased during the 16-month study period. In contrast, PMP1000 treatment ameliorated the bone loss mainly at the cortical diaphysis by decreasing bone turnover, as indicated by the lowered plasma bone-specific alkaline phosphatase and osteocalcin levels. Generally, changes in the cortical bone geometry were in the opposite direction to the cortical bone mass after PMP1000 treatment. This study indicated that postmenopausal monkeys continuously lose their cortical bone compartment, and they have a higher possibility for long bone fractures. Oral PMP treatment could improve both the bone quantity (BMC and BMD) and quality (bone geometry).
The embryonic stress response to in vitro culture: insight from genomic analysis
Authors: Cagnone Gael , Sirard Marc-André
Published: September 2016

Recent genomic studies have shed light on the impact ofin vitroculture (IVC) on embryonic homeostasis and the differential gene expression profiles associated with lower developmental competence. Consistently, the embryonic stress responses to IVC conditions correlate with transcriptomic changes in pathways related to energetic metabolism, extracellular matrix remodelling and inflammatory signalling. These changes appear to result from a developmental adaptation that enhances a Warburg-like effect known to occur naturally during blastulation. First discovered in cancer cells, the Warburg effect (increased glycolysis under aerobic conditions) is thought to result from mitochondrial dysfunction. In the case of IVC embryos, culture conditions may interfere with mitochondrial maturation and oxidative phosphorylation, forcing cells to rely on glycolysis in order to maintain energetic homeostasis. While beneficial in the short term, such adaptations may lead to epigenetic changes with potential long-term effects on implantation, foetal growth and post-natal health. We conclude that lessening the detrimental effects of IVC on mitochondrial activity would lead to significantly improved embryo quality.
Regulation of the bovine oviductal fluid proteome
Authors: Lamy Julie , Labas Valérie , Harichaux Grégoire , Tsikis Guillaume , Mermillod Pascal , Saint-Dizier Marie
Published: September 2016

Our objective was to investigate the regulation of the proteome in the bovine oviductal fluid according to the stage of the oestrous cycle, to the side relative to ovulation and to local concentrations of steroid hormones. Luminal fluid samples from both oviducts were collected at four stages of the oestrous cycle: pre-ovulatory (Pre-ov), post-ovulatory (Post-ov), and mid- and late luteal phases from adult cyclic cows (18–25 cows/stage). The proteomes were assessed by nanoLC–MS/MS and quantified by label-free method. Totally, 482 proteins were identified including a limited number of proteins specific to one stage or one side. Proportions of differentially abundant proteins fluctuated from 10 to 24% between sides at one stage and from 4 to 20% among stages in a given side of ovulation. In oviductal fluids ipsilateral to ovulation, Annexin A1 was the most abundant protein at Pre-ov compared with Post-ov while numerous heat shock proteins were more abundant at Post-ov compared with Pre-ov. Among differentially abundant proteins, seven tended to be correlated with intra-oviductal concentrations of progesterone. A wide range of biological processes was evidenced for differentially abundant proteins, of which metabolic and cellular processes were predominant. This work identifies numerous new candidate proteins potentially interacting with the oocyte, spermatozoa and embryo to modulate fertilization and early embryo development.
Las relaciones cubano-estadounidenses: las necesidades políticas detrás del acuerdo
Authors: Mazzina Constanza , González Cambel Manuela
Published: September 2016

El acuerdo celebrado entre Cuba y Estados Unidos en el último diciembre de 2014 por el que se acordó la reanudación de las relaciones entre ambos países, después de más de cincuenta años de interrupción demuestra, un cambio histórico y una oportunidad recíproca. El presente artículo hace un recorrido por las relaciones bilaterales en clave histórico-política para luego revisar los hechos que desembocaron en el acuerdo teniendo en cuenta que este implicó una negociación compleja y el esfuerzo de una serie de actores heterogéneos que incluyeron desde el gobierno canadiense, funcionarios de ambos bandos hasta el propio Papa Francisco desde el Vaticano. Luego, el artículo reflexiona sobre las razones del mismo y las metas alcanzadas. Finalmente, presenta los temas pendientes a resolver en la agenda bilateral y se pregunta por el futuro próximo de las relaciones entre ambos países.