bluuebunny/crossref_metadata_2025 huggingface dataset:
A Finite-Time Robust Distributed Cooperative Secondary Control Protocol for Droop-Based Islanded AC Microgrids
Authors: Ullah Shafaat , Khan Laiq , Jamil Mohsin , Jafar Muhammad , Mumtaz Sidra , Ahmad Saghir
Published: May 2021

In this research work, a resilient finite-time consensus-based distributed secondary control protocol is presented for droop-based distributed generating (DG) units of an islanded AC microgrid (MG). Through a multi-agent control structure, the DG units of the microgrid adjust their active power outputs so that they reach an agreed-upon value in a finite time. Concurrently, all the DG units are forced to operate with their frequencies regulated to the reference MG frequency in a finite time, despite time-varying load perturbations. Each DG unit is provided with a hierarchical control architecture, where the primary control is achieved using the droop control method, while the secondary control is established through the proposed distributed control protocol. The communication between DG units takes place over a sparse communication network. The proposed control protocol is robust to both small and sufficiently large communication latencies and it supports the plug-and-play feature of DG units. Different time-domain-based numerical simulations are carried out on a small as well as large microgrid testbenches in Matlab/Simulink and demonstrate the correctness and effectiveness of the proposed distributed control protocol. A comparative study is also presented with the existing distributed control protocol, and it is found that the proposed strategy is superior in its performance.
Refining and Reuse of Waste Lube Oil in SI Engines: A Novel Approach for a Sustainable Environment
Authors: Usman Muhammad , Jamil Muhammad Kashif , Riaz Fahid , Hussain Haris , Hussain Ghulam , Shah Muhammad Haris , Qyyum Muhammad Abdul , Salman Chaudhary Awais , Lee Moonyong
Published: May 2021

The protection of the environment and pollution control are issues of paramount importance. Researchers today are engrossed in mitigating the harmful impacts of petroleum waste on the environment. Lubricating oils, which are essential for the smooth operation of engines, are often disposed of improperly after completing their life. In the experimental work presented in this paper, deteriorated engine oil was regenerated using the acid treatment method and was reused in the engine. The comparison of the properties of reused oil, the engine’s performance, and the emissions from the engine are presented. The reuse of regenerated oil, the evaluation of performance, and emissions establish the usefulness of the regeneration of waste lubricating oil. For the used oil, total acid number (TAN), specific gravity, flash point, ash content, and kinematic viscosity changed by 60.7%, 6.7%, 4.4%, 96%, and 15.5%, respectively, compared with fresh oil. The regeneration partially restored all the lost lubricating oil properties. The performance parameters, brake power (BP), brake specific fuel consumption (BSFC), and exhaust gas temperature (EGT) improved with regenerated oil in use compared with used oil. The emissions CO and NOX contents for acid-treated oil were 9.7% and 17.3% less in comparison with used oil, respectively. Thus, regenerated oil showed improved performance and oil properties along with significantly reduced emissions when employed in an SI engine.
Characteristics of Pyrolysis and Low Oxygen Combustion of Long Flame Coal and Reburning of Residues
Authors: Wang Hua , Zhang Wei , Xin Haihui , Wang Deming , Di Cuicui , Liu Lu
Published: May 2021

To further understand the problems of coal combustion and coalfield fire reignition, this paper researched the reaction characteristics of coal pyrolysis and low oxygen combustion and the reburning oxidation characteristics of residual structure by thermal analysis methods. The results show that temperature promotes both pyrolysis and low oxygen combustion reactions, but low oxygen combustion reaction is more sensitive to temperature changes. As the constant temperature rises, the mass reduction rate of low oxygen combustion of coal samples reaches 80% on average, which is 4 times that of pyrolysis, and the variations of thermogravimetric parameters are also significantly higher than those of pyrolysis. However, the higher the pyrolysis degree of the residues, the stronger their oxidizability, which greatly enhances the intensity and concentration of the secondary combustion, and the mass of residues is reduced by 90% on average. Conversely, because the combustible components are continuously consumed during low oxygen combustion, the reburning characteristics of residues become less obvious. For instance, the weight loss rate slows down, the burning becomes dispersed, and the burning intensity is weakened. In addition, the heat release is reduced from 8662 to 444.5 J/g, and the change trend is just opposite to that of pyrolysis. The above results show that as the constant temperature rises, the pyrolysis reaction greatly shortens the reburning process, while the low oxygen combustion reaction largely inhibits the reburning.
Decentral Energy Generation Potential of Anaerobic Digestion of Black Water and Kitchen Refuse for Eco-District Planning
Authors: Mohammadi Soufia , Monsalvete Álvarez de Uribarri Pilar , Eicker Ursula
Published: May 2021

Biogas technology is an important alternative energy source worldwide. Blackwater and kitchen refuse represent ideal waste streams for bioenergy recovery through anaerobic co-digestion. Modeling of the biokinetics of anaerobic digestion on several aspects, such as microbial activity, substrate degradation, and methane production, from co-digestion of black water (BW) and kitchen refuse (KR) was the objective of this research. A mathematical model was developed towards a simulation based on mass balances on biomass, the organic substrate, and biogas. The model was implemented in INSEL and experimental data from the literature were used for model validation. The study shows that the simulation results fit well with the experimental data. The energy consumption and generation potential of anaerobic co-digestion of BW and KR were calculated to investigate if the produced biogas could supply the digester’s energy demand. This study can be used to pre-design anaerobic digestion systems in eco-districts.
Computing Localized Breakthrough Curves and Velocities of Saline Tracer from Ground Penetrating Radar Monitoring Experiments in Fractured Rock
Authors: Giertzuch Peter-Lasse , Shakas Alexis , Doetsch Joseph , Brixel Bernard , Jalali Mohammadreza , Maurer Hansruedi
Published: May 2021

Solute tracer tests are an established method for the characterization of flow and transport processes in fractured rock. Such tests are often monitored with borehole sensors which offer high temporal sampling and signal to noise ratio, but only limited spatial deployment possibilities. Ground penetrating radar (GPR) is sensitive to electromagnetic properties, and can thus be used to monitor the transport behavior of electrically conductive tracers. Since GPR waves can sample large volumes that are practically inaccessible by traditional borehole sensors, they are expected to increase the spatial resolution of tracer experiments. In this manuscript, we describe two approaches to infer quantitative hydrological data from time-lapse borehole reflection GPR experiments with saline tracers in fractured rock. An important prerequisite of our method includes the generation of GPR data difference images. We show how the calculation of difference radar breakthrough curves (DRBTC) allows to retrieve relative electrical conductivity breakthrough curves for theoretically arbitrary locations in the subsurface. For sufficiently small fracture apertures we found the relation between the DRBTC values and the electrical conductivity in the fracture to be quasi-linear. Additionally, we describe a flow path reconstruction procedure that allows computing approximate flow path distances using reflection GPR data from at least two boreholes. From the temporal information during the time-lapse GPR surveys, we are finally able to calculate flow-path averaged tracer velocities. Our new methods were applied to a field data set that was acquired at the Grimsel Test Site in Switzerland. DRBTCs were successfully calculated for previously inaccessible locations in the experimental rock volume and the flow path averaged velocity field was found to be in good accordance with previous studies at the Grimsel Test Site.
Variations in Wood Density, Annual Ring Width and Vessel Properties of Quercus brantii Affected by Crown Dieback
Authors: Soheili Forough , Woodward Stephen , Almasi Isaac , Abdul-Hamid Hazandy , Naji Hamid Reza
Published: May 2021

Tree decline due to climate change results in physiological weaknesses, attacks by harmful pests and pathogens and threats to forest ecosystem stability. In the work described here, the effects of drought on wood density, tree ring width and variations in vessel morphology are investigated in Persian oak (Quercus brantii) in the forest of the Zagros Mountains, Ilam Province, western Iran. Discs are cut from trunks of declined and healthy trees and woodblocks are cut radially from the sapwood near the bark, at a mid-point between the vascular cambium and the pith (middle) and from wood near the pith. Observations are made on transverse sections from the blocks using microscopy. In trees with decline symptoms, wood density is greater than in healthy trees. Furthermore, declining trees have the narrowest ring width, reduced vessel diameter and area and the highest numbers of vessels and tylose in pith towards the bark. It is concluded that changes in anatomical features are associated with the weakening of trees and are components of declining tree health.
Use of Kluyveromyces marxianus to Increase Free Monoterpenes and Aliphatic Esters in White Wines
Authors: Barone Eleonora , Ponticello Giovanna , Giaramida Pieramaria , Squadrito Margherita , Fasciana Teresa , Gandolfo Valentina , Ardizzone Francesco , Monteleone Manuela , Corona Onofrio , Francesca Nicola , Oliva Daniele
Published: May 2021

An increasing interest in novel wine productions is focused on non-Saccharomyces yeasts due to their potential in improving sensory profiles. Although Kluyveromyces marxianus has been originally isolated from grapes and its enzymatic activities are used in oenology, rarely it has been used as co-starter. The K. marxianus Km L2009 strain has been characterized here and selected as a co-starter both at laboratory- and winery-scale fermentation. The Km L2009 strain showed growth of up to 40 (mg/L) of sulfites and 6% (v/v) of ethanol. Gas chromatographic analysis demonstrates that wines produced by mixed fermentation contain remarkably higher quantities of free monoterpenes and aliphatic esters than wines produced only by commercial strains of Saccharomyces cerevisiae. Differences in the volatile organic compound composition produced sensorially distinct wines. In light of these results, it is possible to state that even within the K. marxianus species it is possible to select strains capable of improving the aromatic quality of wines.
Discrimination Ability of Assessors in Check-All-That-Apply Tests: Method and Product Development
Authors: Gere Attila , Bajusz Dávid , Biró Barbara , Rácz Anita
Published: May 2021

Binary similarity measures have been used in several research fields, but their application in sensory data analysis is limited as of yet. Since check-all-that-apply (CATA) data consist of binary answers from the participants, binary similarity measures seem to be a natural choice for their evaluation. This work aims to define the discrimination ability of CATA participants by calculating the consensus values of 44 binary similarity measures. The proposed methodology consists of three steps: (i) calculating the binary similarity values of the assessors, sample pair-wise; (ii) clustering participants into good and poor discriminators based on their binary similarity values; (iii) performing correspondence analysis on the CATA data of the two clusters. Results of three case studies are presented, highlighting that a simple clustering based on the computed binary similarity measures results in higher quality correspondence analysis with more significant attributes, as well as better sample discrimination (even according to overall liking).
Bioactive Sugarcane Lipids in a Circular Economy Context
Authors: Teixeira Francisca S. , Vidigal Susana S. M. P. , Pimentel Lígia L. , Costa Paula T. , Pintado Manuela E. , Rodríguez-Alcalá Luís M.
Published: May 2021

Most of the global sugar and ethanol supply trade comes from the harvesting of Saccharum officinarum (i.e., sugarcane). Its industrial processing results in numerous by-products and waste streams, such as tops, straw, filter cake, molasses and bagasse. The recovery of lipids (i.e., octacosanol, phytosterols, long-chain aldehydes and triterpenoids) from these residues is an excellent starting point for the development of new products for various application fields, such as health and well-being, representing an important feature of the circular economy. By selecting green scalable extraction procedures, industry can reduce its environmental impact. Refluxed ethanol extraction methods have been demonstrated to meet these characteristics. On the other hand, effective non-solvent methodologies such as molecular distillation and supercritical CO2 extraction can fractionate lipids based on high temperature and pressure application with similar yields. Sugarcane lipophilic extracts are usually analyzed through gas chromatography (GC) and liquid chromatography (LC) techniques. In many cases, the identification of such compounds involves the development of high-temperature GC–MS/FID techniques. On the other hand, for the identification and quantification of thermolabile lipids, LC–MS techniques are suitable for the separation and identification of major lipid classes. Generically, its composition includes terpenes, phytosterols, tocopherol, free fatty acids, fatty alcohols, wax esters, triglycerides, diglycerides and monoglycerides. These compounds are already known for their interesting application in various fields such as pharma and cosmetics due to their anti-hypercholesterolemic, anti-hyperglycemic, antioxidant and anti-inflammatory properties.
Construction and Application of EGCG-Loaded Lysozyme/Pectin Nanoparticles for Enhancing the Resistance of Nematodes to Heat and Oxidation Stresses
Authors: Zhang Yu , Lin Liufeng , Cui Hao , Li Bin , Tian Jing
Published: May 2021

Novel nanoparticles (NPs) were constructed with lysozyme (LY) and pectin (Ps) through self-assembly, which were used as a carrier to encapsulate epigallocatechin-3-gallate (EGCG). The binding of EGCG and LY is a static quenching process. Hydrogen bonds might play a major role in the formation of NPs, which has also been verified by a lower binding constant of EGCG with LY/Ps NPs. Meanwhile, EGCG could lead to conformational and microenvironmental changes of LY, resulting in more folding of LY secondary structures. In addition, attaching Ps to LY might inhibit LY aggregation induced by addition of free EGCG. At the LY/Ps mass ratio of 1:1, the constructed LY/Ps NPs had a high EGCG-loading capacity without a significant change in mean particle size, thus, our NPs could be used as an effective nanocarrier for loading EGCG. In vivo, compared with free EGCG, EGCG loaded onto LY/Ps NPs significantly increased Caenorhabditis elegans’ (C. elegans) resistance to heat stress and oxidative injury and prolonged their lifespan. This study provides theoretical basis and reference for constructing nanoactive substance carriers so as to improve the resistance of organisms to heat stress and oxidative damage and to increase their survival rate and extend their lifespan under environment stresses.
Mild Pretreatments to Increase Fructose Consumption in Saccharomyces cerevisiae Wine Yeast Strains
Authors: Karaoglan Hatice Aybuke , Ozcelik Filiz , Musatti Alida , Rollini Manuela
Published: May 2021

The present research investigates the effect of different pretreatments on glucose and fructose consumption and ethanol production by four Saccharomyces cerevisiae wine strains, three isolated and identified from different wine regions in Turkey and one reference strain. A mild stress temperature (45 °C, 1 h) and the presence of ethanol (14% v/v) were selected as pretreatments applied to cell cultures prior to the fermentation step in synthetic must. The goodness fit of the mathematical models was estimated: linear, exponential decay function and sigmoidal model were evaluated with the model parameters R2 (regression coefficient), RMSE (root mean square error), MBE (mean bias error) and χ2 (reduced Chi-square). Sigmoidal function was determined as the most suitable model with the highest R2 and lower RMSE values. Temperature pretreatment allowed for an increase in fructose consumption rate by two strains, evidenced by a t90 value 10% lower than the control. One of the indigenous strains showed particular promise for mild temperature treatment (45 °C, 1 h) prior to the fermentation step to reduce residual glucose and fructose in wine. The described procedure may be effective for indigenous yeasts in preventing undesirable sweetness in wines.
One-Day Molecular Detection of Salmonella and Campylobacter in Chicken Meat: A Pilot Study
Authors: Zendrini Andrea , Carta Valentina , Filipello Virginia , Ragni Laura , Cosciani-Cunico Elena , Arnaboldi Sara , Bertasi Barbara , Franceschi Niccolò , Ajmone-Marsan Paolo , De Medici Dario , Losio Marina Nadia
Published: May 2021

Salmonella and Campylobacter ssp. are bacterial pathogens responsible for most foodborne infections in EU countries. Poultry serves as a reservoir for these pathogens, and its important role in the meat industry makes it essential to develop a rapid detection assay able to provide results in one day. Indeed, the rapid identification of foodborne pathogens is an important instrument for the monitoring and prevention of epidemic outbreaks. To date, Salmonella and Campylobacter screening is mainly conducted through molecular methods (PCR or real-time PCR) performed after 18–24 h long enrichments. In this study, we evaluated short enrichments (0, 2, 4, and 6 h) combined with a colorimetric loop-mediated isothermal AMPlification (LAMP) or real-time PCR to detect Salmonella and Campylobacter in poultry meat contaminated at different concentration levels (101, 103, and 105 CFU/g). Our results show that real-time PCR allows the detection of Salmonella and Campylobacter, even after shorter enrichment times than prescribed by ISO references; particularly, it detected Salmonella down to 101 CFU/g since T0 and Campylobacter from 103 CFU/g since T0. Detection with LAMP was comparable to real-time PCR without the requirement of a thermal cycler and with shorter execution times. These characteristics make colorimetric LAMP a valid alternative when one-day results are needed, improving the timely identification of positive meat batches, even in the absence of specialized instrumentation.
Development of a Home Meal Replacement Product Containing Braised Mackerel (Scomber japonicus) with Radish (Raphanus sativus)
Authors: Tirtawijaya Gabriel , Kim Seung Rok , Cho Woo Hee , Sohn Jae Hak , Kim Jin-Soo , Choi Jae-Suk
Published: May 2021

The coronavirus disease pandemic has contributed to increasing convenience in food preferences. Home meal replacement (HMR) products are ready-to-eat, -cook, or -heat foods, providing convenience for consumers. We developed a HMR product containing mackerel as a protein- and lipid-rich source using various food-processing technologies to maintain its nutritional content and prolong shelf life. The HMR product contained mackerel, radish, and sauce in a ratio of 5:1:4. Raw frozen mackerels were thawed by using a high-frequency defroster before being braised using a superheated steam roaster. Response surface methodology was employed to obtain the optimal heating conditions of 181 °C for 9 min. The final test HMR product was packed in a polypropylene plastic bowl prior to freezing at −35 °C for 1 h using a quick freezing system. The HMR product developed using these technologies exhibited stable microbiological and chemical properties for 90 days of storage. Sensory scores gradually decreased with increasing storage temperature and time. Protein content in the HMR product was 13%, 40% of which comprised essential amino acids; lipid content was 13.4%, 18% of which was composed of docosahexaenoic acid. The HMR product can preserve its quality and is considered safe for consumption for up to 40 months of storage at −18 °C.
Probing Magnetic Fields and Acceleration Mechanisms in Blazar Jets with X-ray Polarimetry
Authors: Tavecchio Fabrizio
Published: May 2021

X-ray polarimetry promises us an unprecedented look at the structure of magnetic fields and on the processes at the base of acceleration of particles up to ultrarelativistic energies in relativistic jets. Crucial pieces of information are expected from observations of blazars (that are characterized by the presence of a jet pointing close to the Earth), in particular of the subclass defined by a synchrotron emission extending to the X-ray band (so-called high synchrotron peak blazars, HSP). In this review, I give an account of some of the models and numerical simulations developed to predict the polarimetric properties of HSP at high energy, contrasting the predictions of scenarios assuming particle acceleration at shock fronts with those that are based on magnetic reconnection, and I discuss the prospects for the observations of the upcoming Imaging X-ray Polarimetry Explorer (IXPE) satellite.
A Large Family with p.Arg554His Mutation in ABCD1: Clinical Features and Genotype/Phenotype Correlation in Female Carriers
Authors: Campopiano Rosa , Femiano Cinzia , Chiaravalloti Maria Antonietta , Ferese Rosangela , Centonze Diego , Buttari Fabio , Zampatti Stefania , Fanelli Mirco , Amatori Stefano , D’Alessio Carmelo , Giardina Emiliano , Fornai Francesco , Biagioni Francesca , Storto Marianna , Gambardella Stefano
Published: May 2021

X-linked adrenoleukodystrophy (X-ALD, OMIM #300100) is the most common peroxisomal disorder clinically characterized by two main phenotypes: adrenomyeloneuropathy (AMN) and the cerebral demyelinating form of X-ALD (cerebral ALD). The disease is caused by defects in the gene for the adenosine triphosphate (ATP)-binding cassette protein, subfamily D (ABCD1) that encodes the peroxisomal transporter of very-long-chain fatty acids (VLCFAs). The defective function of ABCD1 protein prevents β-oxidation of VLCFAs, which thus accumulate in tissues and plasma, to represent the hallmark of the disease. As in many X-linked diseases, it has been routinely expected that female carriers are asymptomatic. Nonetheless, recent findings indicate that most ABCD1 female carriers become symptomatic, with a motor disability that typically appears between the fourth and fifth decade. In this paper, we report a large family in which affected males died during the first decade, while affected females develop, during the fourth decade, progressive lower limb weakness with spastic or ataxic-spastic gait, tetra-hyperreflexia with sensory alterations. Clinical and genetic evaluations were performed in nine subjects, eight females (five affected and three healthy) and one healthy male. All affected females were carriers of the c.1661G>A (p.Arg554His, rs201568579) mutation. This study strengthens the relevance of clinical symptoms in female carriers of ABCD1 mutations, which leads to a better understanding of the role of the genetic background and the genotype-phenotype correlation. This indicates the relevance to include ABCD1 genes in genetic panels for gait disturbance in women.
Evolutionary Dynamics of Wild Populations
Authors: Legrand Delphine , Blanchet Simon
Published: May 2021

Wild populations are facing rapid and sometimes extreme environmental changes that are currently exacerbated by pressing human activities [...]
Benthic Foraminiferal Response to Sedimentary Processes in a Prodeltaic Environment: The Gulf of Patti Case Study (Southeastern Tyrrhenian Sea)
Authors: Di Bella Letizia , Pierdomenico Martina , Bove Cristiano , Casalbore Daniele , Ridente Domenico
Published: May 2021

Analyses of benthic foraminiferal assemblages were carried out on sediment samples collected in the Gulf of Patti (NE Sicily, Tyrrhenian Sea), where high sedimentation rates in front of the Mazzarrà River led to the growth of a prodelta. The frequency of riverine sedimentary fluxes is testified by the widespread occurrence of erosional and depositional bedforms indicative of high-energy processes on the prodelta slope.The frequency of riverine sedimentary fluxes suggests the widespread occurrence of erosional and depositional bedforms indicative of high-energy processes on the prodelta slope. The study aimed to assess the spatial distribution of benthic foraminiferal assemblages and sediment grain size along different sectors of this prodelta to define any relationship between the foraminiferal assemblages, the environmental gradients and the sedimentary processes. In particular, we focused on the role of the highly energetic impulsive torrential inputs that dominate the depositional environment and likely affect food supply and its control on the foraminiferal density and biodiversity. The dominance of opportunistic agglutinated taxa associated with hyaline eutrophic species is a distinctive character likely related to organic matter enrichment and physical disturbance associated with inputs from torrential rivers.
COVID-19 Era Social Isolation among Older Adults
Authors: MacLeod Stephanie , Tkatch Rifky , Kraemer Sandra , Fellows Annette , McGinn Michael , Schaeffer James , Yeh Charlotte S.
Published: May 2021

Risk of COVID-19 exposure and more severe illness are serious concerns for older adults. Social distancing has worsened existing social isolation, with severe impacts on connectedness among seniors. The pandemic is threatening to cause an extended health crisis, with impacts including serious health consequences. Our primary purpose is to summarize emerging research describing the impacts of the pandemic on social isolation among older adults. A streamlined search was conducted to fit the scope of this literature review. Common research databases and mainstream resources and websites were utilized to identify research published or released in 2020 to align with the pandemic. Early research indicates that the pandemic has worsened social isolation among older adults. Social isolation has become urgent, as seniors have lost their usual connections due to social distancing. While safety measures are critical to prevent virus exposure, this approach must be balanced with maintaining social connectedness. The pandemic highlights the importance of social connections, with significant impacts on both community-living older adults and those in nursing facilities. Safety protocols have created a paradox of reduced risk along with greater harm. Consequently, adapted approaches are urgently needed to address the consequences of a long-term social recession.
Relationship between Emotional Intelligence, Sleep Quality and Body Mass Index in Emergency Nurses
Authors: Miguez-Torres Noelia , Martínez-Rodríguez Alejandro , Martínez-Olcina María , Miralles-Amorós Laura , Reche-García Cristina
Published: May 2021

Nurses have long working hours with high psychological burdens. In addition, in the emergency department, nurses are required to quickly adapt emotionally. The aim of this study was to describe and relate emotional intelligence (EI) skills of emergency nurses, their body mass index (BMI) and sleep quality. For this purpose, a cross-sectional was carried out in which the perceived emotional intelligence test and the Pittsburgh sleep quality index were applied. Sixty-two emergency nurses (48 women and 14 men) participated. The results indicated that the majority of them present adequate levels of EI, with no differences by gender. Younger nurses showed a better ability to feel, express and understand emotional states than the older ones, while the ability to regulate emotional states occurred in the opposite way. Nurses who have been working for several years showed a better ability to regulate emotions than those with less experience. Those who were overweight grade II and obese type I expressed their feelings better, also the regulation of emotional states decreased as weight increased. Finally, it has been observed that the quality of sleep of emergency nurses is significantly altered, and that this lack of sleep may affect their ability to process emotions.
Development and Evaluation of Psychometric Properties Regarding the Whole Person Health Scale for Employees of Hospital to Emphasize the Importance of Health Awareness of the Workers in the Hospital
Authors: Liu Chih-Ju , Pi Shih-Hsuan , Fang Chun-Kai , Wu Te-Yu
Published: May 2021

(1) Background: Whole person health (WPH) is important among employees in hospitals. It will affect their performance and attitude toward patient care and organization. This project was designed to develop and assess the validity and reliability of utilizing the Whole Person Health Scale for Employees of a Hospital (WPHS-EH) to determine overall employee health. (2) Methods: A mixed-methods focus group and cross-sectional survey was adopted. Employees held six focus groups, with 62 employees from different departments in medical center in Taiwan. After analyzing the interview content, five experts tested its validity, and the 14-item WPHS-EH scale was analyzed. This was followed by an additional 900 participants questionnaire survey, response rate: 94.9%. Descriptive statistics, Cronbach’s alpha, exploratory factor analysis (EFA), and items analysis were used. Additionally, the scale was implemented to conducted confirmatory factor analysis (CFA) test for validity. (3) Results: Three dimensions were extracted from the questionnaires by EFA: “hospital circumstance and system”, “professional and interpersonal interaction” and “workload and harm”. The Cronbach’s alpha of the WPHS-EH scale was 0.82, while the three sub-dimensions were all significantly correlated with total scores. CFA confirmed the scale construct validity, with a good model fit. (4) Conclusions: The WPHS-EH is a reliable measurement tool to assess the effects of hospitals’ Whole Person Health among employees. The intent of the WPHS-EH was to provide a reliable scale to analyze the work environment for hospital staff and useful information to healthcare administrators interested in improving the staff’s whole person health.
Burden of Treatment among Elderly Patients with Cancer: A Scoping Review
Authors: Sav Adem , McMillan Sara S. , Akosile Adeola
Published: May 2021

Background: The objective of this scoping review is to understand how treatment burden is experienced in elderly patients with cancer and what the most prevalent dimensions of treatment burden are among this population. According to one conceptual model, there are six dimensions of treatment burden, including financial, medication, administrative, time/travel, lifestyle, and healthcare. Methods: A scoping review methodology framework was used to collected data from EMBASE CINAHL (Cumulative Index to Nursing and Allied Health Literature), Medline/PubMed, Scopus, Web of Science, Embase, and Cochrane from 2000 to March 2020. Studies which focused on treatment burden among elderly patients with cancer (+65 years) were selected. Data were extracted using a standardized proforma. Results: The results identified 3319 total papers. Of these, 24 met the inclusion criteria and were included in the scoping review. A significant proportion of these studies was conducted in the United States (n = 10) using self-reported, cross-sectional data. Financial burden was the most prevalent dimension of treatment burden, with 11 studies focusing on the direct and indirect costs associated with cancer treatment. Other but less obvious aspects of treatment burden elderly patients experienced included the length of time taken to access and administer treatment and medication-related burdens. Conclusions: Emerging findings suggest that the financial aspects of cancer treatment are a significant burden for most elderly cancer patients. Personalized healthcare interventions targeting ways to reduce and screen for treatment burden, particularly those related to cost, are urgently needed.
Clinical Factors Associated with Asymptomatic Women Having Inconclusive Screening Mammography Results: Experiences from a Single Medical Center in Taiwan
Authors: Wang Chun-Li , Hsu Pi-Shan , Lin Chia-Yen , Yang Shun-Fa
Published: May 2021

Screening mammography is used worldwide for the early detection of breast cancer in women experiencing no symptoms. The Breast Imaging Reporting and Database System (BI-RADS) is used to report mammographic findings. However, little is known about the clinical characteristics of Asian women with BI-RADS category 0, and we aimed to explore such characteristics in the context of Taiwan. This retrospective cross-sectional study was conducted using data from a single tertiary medical center. We examined the association of blood test data and estrogen exposure–related medical histories with BI-RADS reports from screening mammography of 4280 women between 1 January 2010 and 31 July 2019. The data of 4280 participants were evaluated, and they were categorized into BI-RADS category 0 (n = 413; 9.6%) and 1–5 (n = 3867; 90.4%) subgroups. In a multivariate analysis, breast surgery history and premenopausal status had a positive relationship with a category 0 status, with respective risk increases of 64% and 34% (p = 0.010 and 0.013). Hormone contraceptive use for ≥5 years was a negative independent predictor of having a category 0 status. In conclusion, breast surgery history and premenopausal status significantly increased the likelihood of individuals having incomplete mammographic findings, even when they were older than 45 years. Identifying related factors before screening mammography is helpful for clinical physicians to arrange more proper and alternative examination and obtain a definite diagnosis.
Climate Trends at a Hotspot of Chronic Kidney Disease of Unknown Causes in Nicaragua, 1973–2014
Authors: Petropoulos Zoe E. , Ramirez-Rubio Oriana , Scammell Madeleine K. , Laws Rebecca L. , Lopez-Pilarte Damaris , Amador Juan José , Ballester Joan , O’Callaghan-Gordo Cristina , Brooks Daniel R.
Published: May 2021

An ongoing epidemic of chronic kidney disease of uncertain etiology (CKDu) afflicts large parts of Central America and is hypothesized to be linked to heat stress at work. Mortality rates from CKDu appear to have increased dramatically since the 1970s. To explore this relationship, we assessed trends in maximum and minimum temperatures during harvest months between 1973 and 2014 as well as in the number of days during the harvest season for which the maximum temperature surpassed 35 °C. Data were collected at a weather station at a Nicaraguan sugar company where large numbers of workers have been affected by CKDu. Monthly averages of the daily maximum temperatures between 1996 and 2014 were also compared to concurrent weather data from eight Automated Surface Observing System Network weather stations across Nicaragua. Our objectives were to assess changes in temperature across harvest seasons, estimate the number of days that workers were at risk of heat-related illness and compare daily maximum temperatures across various sites in Nicaragua. The monthly average daily maximum temperature during the harvest season increased by 0.7 °C per decade between 1973 and 1990. The number of days per harvest season with a maximum temperature over 35 °C increased by approximately five days per year between 1974 and 1990, from 32 days to 114 days. Between 1991 and 2013, the number of harvest days with a maximum temperature over 35 °C decreased by two days per year, and the monthly average daily maximum temperature decreased by 0.3 °C per decade. Comparisons with weather stations across Nicaragua demonstrate that this company is located in one of the consistently hottest regions of the country.
Occupational Health Hazards: Employer, Employee, and Labour Union Concerns
Authors: Rikhotso Oscar , Morodi Thabiso John , Masekameni Daniel Masilu
Published: May 2021

This review paper examines the extent of employer, worker, and labour union concerns to occupational health hazard exposure, as a function of previously reported and investigated complaints. Consequently, an online literature search was conducted, encompassing publicly available reports resulting from investigations, regulatory inspection, and enforcement activities conducted by relevant government structures from South Africa, the United Kingdom, and the United States. Of the three countries’ government structures, the United States’ exposure investigative activities conducted by the National Institute for Occupational Safety and Health returned literature search results aligned to the study design, in the form of health hazard evaluation reports reposited on its online database. The main initiators of investigated exposure cases were employers, workers, and unions at 86% of the analysed health hazard evaluation reports conducted between 2000 and 2020. In the synthesised literature, concerns to exposure from chemical and physical hazards were substantiated by occupational hygiene measurement outcomes confirming excessive exposures above regulated health and safety standards in general. Recommendations to abate the confirmed excessive exposures were made in all cases, highlighting the scientific value of occupational hygiene measurements as a basis for exposure control, informing risk and hazard perception. Conclusively, all stakeholders at the workplace should have adequate risk perception to trigger abatement measures.
The Spatial Overlap of Police Calls Reporting Street-Level and Behind-Closed-Doors Crime: A Bayesian Modeling Approach
Authors: Marco Miriam , Gracia Enrique , López-Quílez Antonio , Lila Marisol
Published: May 2021

Traditionally, intimate-partner violence has been considered a special type of crime that occurs behind closed doors, with different characteristics from street-level crime. The aim of this study is to analyze the spatial overlap of police calls reporting street-level and behind-closed-doors crime. We analyzed geocoded police calls in the 552 census-block groups of the city of Valencia, Spain, related to street-level crime (N = 26,624) and to intimate-partner violence against women (N = 11,673). A Bayesian joint model was run to analyze the spatial overlap. In addition, two Bayesian hierarchical models controlled for different neighborhood characteristics to analyze the relative risks. Results showed that 66.5% of the total between-area variation in risk of reporting street-level crime was captured by a shared spatial component, while for reporting IPVAW the shared component was 91.1%. The log relative risks showed a correlation of 0.53, with 73.6% of the census-block groups having either low or high values in both outcomes, and 26.4% of the areas with mismatched risks. Maps of the shared component and the relative risks are shown to detect spatial differences. These results suggest that although there are some spatial differences between police calls reporting street-level and behind-closed-doors crime, there is also a shared distribution that should be considered to inform better-targeted police interventions.
Sex Differences in the Relationships between Forms of Peer Victimization and Reactive and Proactive Aggression in Schoolchildren
Authors: Fung Annis Lai-Chu
Published: May 2021

The original study investigated sex differences in the relationships between multiple forms of peer victimization (physical victimization, verbal victimization, and social exclusion) and subtypes of aggression (reactive aggression and proactive aggression) in schoolchildren. A self-report questionnaire assessing levels of peer victimization and aggression was administered to 3790 schoolchildren (1916 males and 1874 females) aged 11 to 17 (M = 13.19; SD = 1.17) from 10 middle schools in Hong Kong. The pure effect of each subtype of aggression were evaluated by statistically controlling for another subtype of aggression in analyses. Furthermore, participants were classified as non-aggressors, reactive aggressors, proactive aggressors, and reactive–proactive aggressors to investigate their differences in specific forms of peer victimization. Data were analyzed by hierarchical linear regression and ANOVA. The results showed: (1) Sex significantly moderated the relationship between specific forms of peer victimization and subtypes of aggression; (2) In males, reactive aggression was positively predicted by verbal victimization; proactive aggression was positively predicted by physical victimization and social exclusion, and negatively predicted by verbal victimization; (3) In females, reactive aggression was positively predicted by physical victimization and social exclusion; proactive aggression was negatively predicted by social exclusion; and (4) Reactive–proactive aggressors reported more physical victimization than other types of aggressors. The findings have significant implications for distinctive functions of reactive and proactive aggression and the need to develop differentiated interventions for male and female schoolchildren.
Constitutive Expression of TERT Enhances β-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos
Authors: Xu Lianguang , Idrees Muhammad , Joo Myeong-Don , Sidrat Tabinda , Wei Yiran , Song Seok-Hwan , Lee Kyeong-Lim , Kong Il-Keun
Published: May 2021

Age-associated decline in oocyte quality is one of the dominant factors of low fertility. Aging alters several key processes, such as telomere lengthening, cell senescence, and cellular longevity of granulosa cells surrounding oocyte. To investigate the age-dependent molecular changes, we examined the expression, localization, and correlation of telomerase reverse transcriptase (TERT) and β-Klotho (KLB) in bovine granulosa cells, oocytes, and early embryos during the aging process. Herein, cumulus-oocyte complexes (COCs) obtained from aged cows (>120 months) via ovum pick-up (OPU) showed reduced expression of β-Klotho and its co-receptor fibroblast growth factor receptor 1 (FGFR1). TERT plasmid injection into pronuclear zygotes not only markedly enhanced day-8 blastocysts’ development competence (39.1 ± 0.8%) compared to the control (31.1 ± 0.5%) and D-galactose (17.9 ± 1.0%) treatment groups but also enhanced KLB and FGFR1 expression. In addition, plasmid-injected zygotes displayed a considerable enhancement in blastocyst quality and implantation potential. Cycloastragenol (CAG), an extract of saponins, stimulates telomerase enzymes and enhances KLB expression and alleviates age-related deterioration in cultured primary bovine granulosa cells. In conclusion, telomerase activation or constitutive expression will increase KLB expression and activate the FGFR1/β-Klotho pathway in bovine granulosa cells and early embryos, inhibiting age-related malfunctioning.
MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa
Authors: Ma Miao , Lustig Margaux , Salem Michèle , Mengin-Lecreulx Dominique , Phan Gilles , Broutin Isabelle
Published: May 2021

One of the major families of membrane proteins found in prokaryote genome corresponds to the transporters. Among them, the resistance-nodulation-cell division (RND) transporters are highly studied, as being responsible for one of the most problematic mechanisms used by bacteria to resist to antibiotics, i.e., the active efflux of drugs. In Gram-negative bacteria, these proteins are inserted in the inner membrane and form a tripartite assembly with an outer membrane factor and a periplasmic linker in order to cross the two membranes to expulse molecules outside of the cell. A lot of information has been collected to understand the functional mechanism of these pumps, especially with AcrAB-TolC from Escherichia coli, but one missing piece from all the suggested models is the role of peptidoglycan in the assembly. Here, by pull-down experiments with purified peptidoglycans, we precise the MexAB-OprM interaction with the peptidoglycan from Escherichia coli and Pseudomonas aeruginosa, highlighting a role of the peptidoglycan in stabilizing the MexA-OprM complex and also differences between the two Gram-negative bacteria peptidoglycans.
Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach
Authors: Bardallo Raquel G. , da Silva Rui Teixeira , Carbonell Teresa , Folch-Puy Emma , Palmeira Carlos , Roselló-Catafau Joan , Pirenne Jacques , Adam René , Panisello-Roselló Arnau
Published: May 2021

The total damage inflicted on the liver before transplantation is associated with several surgical manipulations, such as organ recovery, washout of the graft, cold conservation in organ preservation solutions (UW, Celsior, HTK, IGL-1), and rinsing of the organ before implantation. Polyethylene glycol 35 (PEG35) is the oncotic agent present in the IGL-1 solution, which is an alternative to UW and Celsior solutions in liver clinical transplantation. In a model of cold preservation in rats (4 °C; 24 h), we evaluated the effects induced by PEG35 on detoxifying enzymes and nitric oxide, comparing IGL-1 to IGL-0 (which is the same as IGL-1 without PEG). The benefits were also assessed in a new IGL-2 solution characterized by increased concentrations of PEG35 (from 1 g/L to 5 g/L) and glutathione (from 3 mmol/L to 9 mmol/L) compared to IGL-1. We demonstrated that PEG35 promoted the mitochondrial enzyme ALDH2, and in combination with glutathione, prevented the formation of toxic aldehyde adducts (measured as 4-hydroxynonenal) and oxidized proteins (AOPP). In addition, PEG35 promoted the vasodilator factor nitric oxide, which may improve the microcirculatory disturbances in steatotic grafts during preservation and revascularization. All of these results lead to a reduction in damage inflicted on the fatty liver graft during the cold storage preservation. In this communication, we report on the benefits of IGL-2 in hypothermic static preservation, which has already been proved to confer benefits in hypothermic oxygenated dynamic preservation. Hence, the data reported here reinforce the fact that IGL-2 is a suitable alternative to be used as a unique solution/perfusate when hypothermic static and preservation strategies are used, either separately or combined, easing the logistics and avoiding the mixture of different solutions/perfusates, especially when fatty liver grafts are used. Further research regarding new therapeutic and pharmacological insights is needed to explore the underlying mitochondrial mechanisms exerted by PEG35 in static and dynamic graft preservation strategies for clinical liver transplantation purposes.