bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolomic Analysis and Antioxidant Potential of Tropical Propolis Nonpolar Extracts from Colombia
Authors: Márquez David Guillermo Piedrahita , Maraschin Marcelo , Oliveira Eva Regina , Ovalle Lady Viviana Camargo , Díaz-Moreno Consuelo , Suárez-Mahecha Héctor
Published: May 2023

Bioactive compounds of natural matrices are of interest because of their application in the food and pharmaceutical industries. One important source of bioactives is propolis, a resinous biomass that bees make from the plants surrounding the hive. Regarding Colombian propolis, studies have mostly been directed towards identifying flavonoids and their biological activity in vitro. There are no works on the oil extract of propolis and its chemical composition and bioactivity through metabolomic analysis. In this sense, this work studied the volatile composition of propolis oil extract samples from Colombia, following a metabolomic approach; in this work, the oily Colombian propolis extracts (OECP) obtained by an ultrasound assisted extraction (UAE) with different solvents were studied using spectroscopy and physicochemical analysis. A strong correlation was observed between the antioxidant activity and their concentrations of polyphenols, terpenoids, and carotenoids. Simultaneously, it was possible to expand the number of compounds identified by applying FTIR spectroscopy to the sample analysis, relating infrared bands to specific compounds. Besides, it was also possible to discriminate the samples according to their geographical origin. Colombian propolis oil extracts have characteristics as bioactive compounds such as the sesquiterpenes bisabolol, α-zingiberene, β-bisabolene, and α-trans-bergamotene and the monoterpenes α-pinene, linalool, and p-cymene.
Application of Metaheuristic Algorithms and ANN Model for Univariate Water Level Forecasting
Authors: Mohammed Sarah J. , Zubaidi Salah L. , Al-Ansari Nadhir , Mohammed Ridha Hussein , Dulaimi Anmar , Al-Khafaji Ruqayah
Published: May 2023

With the rapid development of machine learning (ML) models, the artificial neural network (ANN) is being increasingly applied for forecasting hydrological processes. However, researchers have not treated hybrid ML models in much detail. To address these issues, this study herein suggests a novel methodology to forecast the monthly water level (WL) based on multiple lags of the Tigris River in Al-Kut, Iraq, over ten years. The methodology includes preprocessing data methods, and the ANN model optimises with a marine predator algorithm (MPA). In the optimisation procedure, to decrease uncertainty and expand the predicting range, the slime mould algorithm (SMA-ANN), constriction coefficient-based particle swarm optimisation and chaotic gravitational search algorithms (CPSOCGSA-ANN), and particle swarm optimisation (PSO-ANN) are applied to compare and validate the MPA-ANN model performance. Analysis of results revealed that the data pretreatment methods improved the original data quality and selected the ideal predictors’ scenario by singular spectrum analysis and mutual information methods, respectively. For example, the correlation coefficient of the first lag improved from 0.648 to 0.938. Depending on various evaluation metrics, MPA-ANN tends to forecast WL better than SMA-ANN, PSO-ANN, and CPSOCGSA-ANN algorithms with coefficients of determination of 0.94, 0.81, 0.85, and 0.90, respectively. Evidence shows that the proposed methodology yields excellent results, with a scatter index equal to 0.002. The research outcomes represent an additional step towards evolving various hybrid ML techniques, which are valuable to practitioners wishing to forecast WL data and the management of water resources in light of environmental shifts.
Supplementary Table S7 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Authors: Alsadhan Anfal , Chen Jonathan , Gaglione Erika M. , Underbayev Chingiz , Tuma Pamela L. , Tian Xin , Freeman Lita A. , Baskar Sivasubramanian , Nierman Pia , Soto Susan , Itsara Andy , Ahn Inhye E. , Sun Clare , Bibikova Elena , Hartmann Tanja Nicole , Mhibik Maissa , Wiestner Adrian
Published: May 2023

Supplementary Table S7. DEGs for 1 month Comparison of CD49d+ and CD49d-
Supplementary Figure S1 from CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Authors: Alsadhan Anfal , Chen Jonathan , Gaglione Erika M. , Underbayev Chingiz , Tuma Pamela L. , Tian Xin , Freeman Lita A. , Baskar Sivasubramanian , Nierman Pia , Soto Susan , Itsara Andy , Ahn Inhye E. , Sun Clare , Bibikova Elena , Hartmann Tanja Nicole , Mhibik Maissa , Wiestner Adrian
Published: May 2023

Supplementary Figure S1. Tumor volume in CD49d+ and CD49d− CLL during acalabrutinib treatment
Supplementary Table S2 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Table 2. Tumor types and characteristics for Nanostring and immunofluorescence data analysis
Supplementary Table S1 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Table 1. Representativeness of Study Participants
Supplemental Table S7 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Authors: Gibson Christopher J. , Fell Geoffrey , Sella Tal , Sperling Adam S. , Snow Craig , Rosenberg Shoshana M. , Kirkner Greg , Patel Ashka , Dillon Deborah , Bick Alexander G. , Neuberg Donna , Partridge Ann H. , Miller Peter G.
Published: May 2023

Possible germline mutations (VAF > 0.35) predicted to impair protein function via premature stop (nonsense), splicing alterations, or a frameshift
Supplementary Figure S6 from Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip
Published: May 2023

Supplemental Figure 6. Tumor biopsy gene expression changes in antigen presenting pathways after SYNB1891 treatment.
Supplemental Table S3 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Authors: Gibson Christopher J. , Fell Geoffrey , Sella Tal , Sperling Adam S. , Snow Craig , Rosenberg Shoshana M. , Kirkner Greg , Patel Ashka , Dillon Deborah , Bick Alexander G. , Neuberg Donna , Partridge Ann H. , Miller Peter G.
Published: May 2023

CHIP Mutations Identified in One-Year Samples
Supplemental Fig. S2 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Authors: Gibson Christopher J. , Fell Geoffrey , Sella Tal , Sperling Adam S. , Snow Craig , Rosenberg Shoshana M. , Kirkner Greg , Patel Ashka , Dillon Deborah , Bick Alexander G. , Neuberg Donna , Partridge Ann H. , Miller Peter G.
Published: May 2023

Associations between Clonal Hematopoiesis (CH) and Survival in the YWS
Data from INTRAVENOUS N-ACETYLCYSTEINE TO PREVENT CISPLATIN-INDUCED HEARING LOSS IN CHILDREN: A NONRANDOMIZED CONTROLLED PHASE 1 TRIAL
Authors: Orgel Etan , Knight Kristin R. , Chi Yueh-Yun , Malvar Jemily , Rushing Teresa , Mena Victoria , Eisenberg Laurie S. , Rassekh Shahrad R. , Ross Colin JD. , Scott Erika N. , Neely Michael , Neuwelt Edward A. , Muldoon Leslie L. , Freyer David R.
Published: May 2023

Abstract
Purpose: Cisplatin-induced hearing loss (CIHL) is common and permanent. As compared to earlier otoprotectants, we hypothesized N-acetylcysteine (NAC) offers potential for stronger otoprotection through stimulation of glutathione production. This study tested the optimal dose, safety, and efficacy of NAC to prevent CIHL. Patients and Methods: In this nonrandomized, controlled Phase 1a/1b trial, children and adolescents newly diagnosed with non-metastatic, cisplatin-treated tumors received NAC intravenously four hours post-cisplatin. The trial performed dose-escalation across three dose levels to establish a safe dose that exceeded the targeted peak serum NAC concentration of 1.5 mM (as identified from preclinical models). Patients with metastatic disease or otherwise ineligible were enrolled in an observation-only/control arm. To evaluate efficacy, serial age-appropriate audiology assessments were performed. Integrated biology examined genes involved in glutathione metabolism and post-NAC glutathione concentrations. Results: Of 52 patients enrolled, 24 received NAC and 28 were in the control arm. The maximum tolerated dose was not reached; analysis of peak [NAC] identified 450 mg/kg as the recommended Phase 2 dose (RP2D). Infusion-related reactions were common. No severe adverse events occurred. Compared to the control arm, NAC decreased likelihood of CIHL at end of cisplatin therapy (odds ratio [OR] 0.13, 95% confidence interval [CI] 0.021-0.847, p=0.033) and recommendations for hearing intervention at end of study (OR 0.082, 95%CI 0.011-0.60, p=0.014). NAC increased glutathione; GSTP1 influenced risk for CIHL and NAC otoprotection. Conclusion: NAC was safe at the RP2D with strong evidence for efficacy to prevent CIHL, warranting further development as a next-generation otoprotectant. Trial number: NCT02094625
Circulating Tumor DNA Biomarkers for Response Assessment in Prostate Cancer
Authors: Sartor Oliver
Published: May 2023

Circulating tumor DNA (ctDNA) is measurable in the majority of metastatic castration-resistant prostate cancer patients. Data indicate that ctDNA present at baseline can serve as a prognostic biomarker and changes in the ctDNA posttreatment can rapidly predict both time to progression and survival.

See related article by Tolmeijer et al., p. 2835
Table S1 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

Table S1 indicating TIL-iPSCs were established from T cells of low frequency along with major tumor neoantigen specific T cells from patient 3784
Figure S3 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

Figure S3: TIL-Tumor cell co-culture resulted in establishment of TIL-iPSCs from tumor reactive T cell clones from patient 1913
FIGURE 2 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

Nonspecific TCR stimulation by αCD3 Ab is not suitable for selective reprogramming of tumor-reactive T cells. A, A summary table of top 10 frequent TCRβ sequences in the starting cells, that is, expanded TIL of patient 4069, indicating the CDR3β amino acid sequence, Vβ family and frequency. The most frequent TCR was the patient's neoantigen-specific TCR (indicated in red). B, A summary table of TCRβ sequences of established TIL-iPSCs by αCD3 Ab stimulation, indicating the CDR3β amino acid sequence, Vβ family and the number of TIL-iPSC clones established. C, A summary table of six candidate TCR pairs including five newly found TCRs (NF TCR 1–5) and one PIR-TCR which were sequenced individually from master tube 6 containing 14 individual iPSC clones. The table indicates TCR pairs, CDR3β sequence, Vβ family, CDR3α sequence, and Vα family. NF, newly found TCR (unknown reactivity); PIR, preidentified reactive TCR. D and E, CD137 (4-1BB) upregulation assay of T cells transduced with candidate TCRα and TCRβ pairs identified from TIL-iPSCs (Fig. 2C). T cells were cocultured with autologous DC pulsed with wild-type (WT) peptide (16 mer or 9 mer) or mutant peptide (9 mer). D shows the representative FACS plots and E shows the percentage of 4-1BB+ cells in each condition. Representative data of three independent experiments from 3 different healthy donor T cells. Mock indicates empty vector transduced T cells used as negative control. F and G, CD137 (4-1BB) upregulation assay of T cells transduced with candidate TCRα and TCRβ pairs identified from TIL-iPSCs (Fig. 2C). T cells were cocultured with autologous, or HLA-matched allogeneic tumor cells derived from the PDXs model. F shows the representative FACS plots and G shows the percentage of 4-1BB+ cells in each condition. Representative data of three independent experiments from 3 different healthy donor T cells. Mock indicates empty vector transduced T cells used as negative control. H, A graph showing the real-time cell growth monitoring (cell count/image) of RFP-overexpressed PDX-derived tumor cell line cultured with T cells transduced with PIR-TCR analyzed by the Incucyte live imaging and analysis system (effector-to-target ratio of 2:1). Empty vector transduced T cells (Mock) and tumor cell alone (TC) were used as negative controls. The results are shown as mean ± SD (N = 4).
FIGURE 1 from Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells
Authors: Islam S.M. Rafiqul , Maeda Takuya , Tamaoki Naritaka , Good Meghan L. , Kishton Rigel J. , Paria Biman C. , Yu Zhiya , Bosch-Marce Marta , Bedanova Nicole M. , Liu Chengyu , Kruhlak Michael J. , Restifo Nicholas P. , Vizcardo Raul
Published: May 2023

TCR stimulation is necessary for T cells to be reprogrammed to T-iPSCs. A, Schematic representation of PBMC derived T-cell reprogramming into iPSC. Whole PB T cells or the sorted populations were stimulated by αCD3/28 beads, and transduced with Sendai virus containing four Yamanaka factors and SV40 large T antigen. Approximately after 20–25 days’ culture in iPSC culture condition, the number of established iPSC colonies were counted. B, A bar graph indicates the numbers of AP-positive ES cell-like iPSC colonies derived from 1E+5 T cells with or without TCR stimulation. N = 3 for each donor. SeV containing four Yamanaka factors (OSKM) or OSKM and SV40 were used. C, Gating strategy to sort four subsets of CD8+ T cells (Naïve, CM, EM, and EMRA). PBMC were stained by antibodies against CD3, CD8, CD62L, CD45RO, CCR7, and CD45RA. CD8+ T cells were first gated on the basis of CD45RO and CD62L expression, followed by the second gate based on CD45RA and CCR7 expression. Four subsets of CD8+ T cells (Naïve, CM, EM, and EMRA) were sorted according to the gates indicated in the flow cytometry panels. D, A summary table showing which subset (Naïve, CM, EM, and EMRA) were reprogrammed to iPSCs by different stimulation methods. Sorted CD8+ T-cell subsets (Naïve, CM, EM, and EMRA) were stimulated by different methods (OKT-3 or αCD3/28 beads) before SeV infection. E, Representative AP, phase contrast, and bright field images were shown to describe the methods of iPSC colonies enumeration from different subsets (Naïve, CM, EM, and EMRA) of CD8 T cells reprogrammed into iPSC in each experiments following transduction of Sendai virus containing four Yamanaka factors and SV40 large T antigen. Each well was seeded with 1E+5 T cells. F, A bar graph indicates the numbers of AP-positive ES cell-like colonies derived from 1E+5 sorted CD8+ naïve/CM/EM/EMRA T cells activated by αCD3/28 beads. N = 3 for each donor.
Figure S5 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring
Authors: Nakhle Jean , Khattar Khattar , Özkan Tülin , Boughlita Adel , Abba Moussa Daouda , Darlix Amelie , Lorcy Frédérique , RIGAU Valérie , BAUCHET Luc , Gerbal-Chaloin Sabine , Daujat-Chavanieu Martine , Bellvert Floriant , Turchi Laurent , Virolle Thierry , Hugnot Jean-Philippe , Buisine Nicolas , Galloni Mireille , Dardalhon Valerie , Rodriguez Anne-Marie , Vignais Marie-Luce
Published: May 2023

MSC mitochondria modify the usage of metabolites by GCSs in response to TMZ
CTRL
Mito TMZ
CTRL
Mito Mito TMZ
(A) Metabolic substrate consumption of GSCs expressed as metabolite initial consumption rates (Biolog MitoPlates). Mean values ± SEM (4 independent experiments).
(B) Production of cis-aconitate, succinate and L-malate expressed as a percentage of all TCA metabolites produced in each experimental condition. Tukey boxplots with one-way ANOVA, *p < 0.05, ***p < 0.001.
Figure S1 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring
Authors: Nakhle Jean , Khattar Khattar , Özkan Tülin , Boughlita Adel , Abba Moussa Daouda , Darlix Amelie , Lorcy Frédérique , RIGAU Valérie , BAUCHET Luc , Gerbal-Chaloin Sabine , Daujat-Chavanieu Martine , Bellvert Floriant , Turchi Laurent , Virolle Thierry , Hugnot Jean-Philippe , Buisine Nicolas , Galloni Mireille , Dardalhon Valerie , Rodriguez Anne-Marie , Vignais Marie-Luce
Published: May 2023

Experimental design and timeline
A Persistência ou o Uso Não Oficial de Topônimos Coloniais na Cidade de Maputo, Moçambique
Authors: Mahumane Jose Jorge , Tembe Joel das Neves
Published: May 2023

Tomando como casos de estudos certos topônimos coloniais e pós-coloniais da cidade de Maputo (antes Lourenço Marques), argumentamos que o novo governo de Moçambique independente usou a mudança da toponímia como forma de apagar os vestígios do colonialismo em lugares estratégicos e de maior visibilidade. Ao mesmo tempo, tolerava os topônimos “apolíticos” ou de menor carga política do período colonial. As mudanças visavam inscrever memórias e identidades ligadas ao passado e ao presente do novo regime. Sustentamos que, nos casos analisados, há a permanência ou o uso não oficial de topônimos ilegais e extintos. Esta questão é abordada à luz da memória, do hábito, e das ações político-estratégicas do governo. Este artigo é de natureza qualitativa e se baseia em fontes primárias e secundárias, em entrevistas e observações pessoais. Todas as fontes foram abordadas de forma crítica tendo em conta os objetivos e juízos de valores daqueles que os produziram.
O resgate da memória: o topônimo do bairro ouro-pretano Cabeças
Authors: Fernandes Fernanda Kelly Mineiro , Mendes Soélis Teixeira do Prado
Published: May 2023

Nosso objetivo é resgatar parte da memória cultural da setecentista Vila Rica, hoje Ouro Preto, por meio da análise do topônimo “Cabeças”, nome atribuído a um dos bairros ouro-pretanos mais antigos. Com base nos estudos onomásticos e nas narrativas dos moradores, discutimos aspectos que extrapolam dados linguísticos e que estão presentes na nomeação de topônimos. A análise dos dados nos mostrou que a configuração geográfica e a posição da localidade em relação à Vila motivaram a escolha toponímica.  Assim, podemos afirmar que, com a recuperação dos contextos histórico, cultural, geográfico e social, que propiciaram a criação do topônimo sob análise, foi possível recuperar-lhe o significado ao trazermos à tona informações subjacentes ao nome e em que situação ele foi atribuído à localidade.
A nomeação toponímica como forma de exclusão: uma análise dos nomes de avenidas, ruas e travessas da cidade de Oeiras-PI
Authors: Santana Messias dos Santos , Moura Layane Albuquerque de
Published: May 2023

O estudo dos nomes próprios de lugares é uma importante fonte para o conhecimento de aspectos sociais, históricos e culturais, do presente ou do passado. Assim, esta pesquisa – que investiga os nomes de vias públicas da cidade de Oeiras, no Piauí – visa a: i) caracterizar os fatores motivadores da denominação toponímica dos espaços analisados; ii) identificar as principais omissões sociopolíticas nas denominações desses espaços urbanos; iii) estabelecer aspectos sócio-históricos de Oeiras revelados nesses topônimos. Para isso, foram analisados 33 mapas de setores censitários e 33 descritivos desses setores, elaborados pelo IBGE para o Censo de 2010. Os resultados indicaram que os nomes de avenidas, ruas e travessas dessa cidade são, quase totalmente, topônimos de natureza antropocultural, e os homenageados, geralmente, são homens e pertencem às classes e atividades profissionais social, histórica e culturalmente privilegiadas.
Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry
Authors: Abou Alaiwi Sarah , Roston Thomas M. , Marstrand Peter , Claggett Brian Lee , Parikh Victoria N. , Helms Adam S. , Ingles Jodie , Lampert Rachel , Lakdawala Neal K. , Michels Michelle , Owens Anjali T. , Rossano Joseph W. , Saberi Sara , Abrams Dominic J. , Ashley Euan A. , Semsarian Christopher , Stendahl John C. , Ware James S. , Miller Erin , Ryan Thomas D. , Russell Mark W. , Day Sharlene M. , Olivotto Iacopo , Vissing Christoffer R. , Ho Carolyn Y.
Published: May 2023

BACKGROUND:

The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD in patients diagnosed with HCM as children.

METHODS:

Data from patients with HCM in the international, multicenter SHaRe (Sarcomeric Human Cardiomyopathy Registry) were analyzed. LVSD was defined as left ventricular ejection fraction <50% on echocardiographic reports. Prognosis was assessed by a composite of death, cardiac transplantation, and left ventricular assist device implantation. Predictors of developing incident LVSD and subsequent prognosis with LVSD were assessed using Cox proportional hazards models.

RESULTS:

We studied 1010 patients diagnosed with HCM during childhood (<18 years of age) and compared them with 6741 patients with HCM diagnosed as adults. In the pediatric HCM cohort, median age at HCM diagnosis was 12.7 years (interquartile range, 8.0–15.3), and 393 (36%) patients were female. At initial SHaRe site evaluation, 56 (5.5%) patients with childhood-diagnosed HCM had prevalent LVSD, and 92 (9.1%) developed incident LVSD during a median follow-up of 5.5 years. Overall LVSD prevalence was 14.7% compared with 8.7% in patients with adult-diagnosed HCM. Median age at incident LVSD was 32.6 years (interquartile range, 21.3–41.6) for the pediatric cohort and 57.2 years (interquartile range, 47.3–66.5) for the adult cohort. Predictors of developing incident LVSD in childhood-diagnosed HCM included age <12 years at HCM diagnosis (hazard ratio [HR], 1.72 [CI, 1.13–2.62), male sex (HR, 3.1 [CI, 1.88–5.2), carrying a pathogenic sarcomere variant (HR, 2.19 [CI, 1.08–4.4]), previous septal reduction therapy (HR, 2.34 [CI, 1.42–3.9]), and lower initial left ventricular ejection fraction (HR, 1.53 [CI, 1.38–1.69] per 5% decrease). Forty percent of patients with LVSD and HCM diagnosed during childhood met the composite outcome, with higher rates in female participants (HR, 2.60 [CI, 1.41–4.78]) and patients with a left ventricular ejection fraction <35% (HR, 3.76 [2.16–6.52]).

CONCLUSIONS:

Patients with childhood-diagnosed HCM have a significantly higher lifetime risk of developing LVSD, and LVSD emerges earlier than for patients with adult-diagnosed HCM. Regardless of age at diagnosis with HCM or LVSD, the prognosis with LVSD is poor, warranting careful surveillance for LVSD, especially as children with HCM transition to adult care.
Association Between Soluble Intercellular Adhesion Molecule-1 and Intracerebral Hemorrhage Outcomes in the FAST Trial
Authors: Witsch Jens , Roh David , Oh Stephanie , Iadecola Costantino , Diaz-Arrastia Ramon , Kasner Scott E. , Mayer Stephan A. , Murthy Santosh B.
Published: May 2023

BACKGROUND:

Neutrophil-mediated inflammation in the acute phase of intracerebral hemorrhage (ICH) worsens outcome in preclinical studies. sICAM-1 (soluble intercellular adhesion molecule-1), an inducible ligand for integrins and cell-cell adhesion molecules, is critical for neutrophil extravasation. We aimed to determine whether serum levels of sICAM-1 are associated with worse outcomes after ICH.

METHODS:

We conducted a post hoc secondary analysis of an observational cohort using data from the FAST trial (Factor-VII for Acute Hemorrhagic Stroke Treatment). The study exposure was the admission serum level of sICAM-1. The coprimary outcomes were mortality and poor outcome (modified Rankin Scale score 4–6) at 90 days. Secondary radiological outcomes were hematoma expansion at 24 hours and perihematomal edema expansion at 72 hours. We used multiple linear and logistic regression analyses to test for associations between sICAM-1 and outcomes, after adjustment for demographics, ICH severity characteristics, change in the systolic blood pressure in the first 24 hours, treatment randomization arm, and the time from symptom onset to study drug administration.

RESULTS:

Of 841 patients, we included 507 (60%) with complete data. Hematoma expansion occurred in 169 (33%), while 242 (48%) had a poor outcome. In multivariable analyses, sICAM-1 was associated with mortality (odds ratio, 1.53 per SD increase [95% CI, 1.15–2.03]) and poor outcome (odds ratio, 1.34 per SD increase [CI, 1.06–1.69]). In multivariable analyses of secondary outcomes, sICAM-1 was associated with hematoma expansion (odds ratio, 1.35 per SD increase [CI, 1.11–1.66]), but was not associated with log-transformed perihematomal edema expansion at 72 hours. In additional analyses stratified by treatment assignment, similar results were noted in the recombinant activated factor-VII arm, but not in the placebo arm.

CONCLUSIONS:

Admission serum levels of sICAM-1 were associated with mortality, poor outcome, and hematoma expansion. Given the possibility of a biological interaction between recombinant activated factor-VII and sICAM-1, these findings highlight the need to further explore the role of sICAM-1 as a potential marker of poor ICH outcomes.
Not Playing by the Rules: Exploratory Play, Rational Action, and Efficient Search
Authors: Chu Junyi , Schulz Laura E.
Published: May 2023

Recent studies suggest children’s exploratory play is consistent with formal accounts of rational learning. Here we focus on the tension between this view and a nearly ubiquitous feature of human play: In play, people subvert normal utility functions, incurring seemingly unnecessary costs to achieve arbitrary rewards. We show that four-and-five-year-old children not only infer playful behavior from observed violations of rational action (Experiment 1), but themselves take on unnecessary costs during both retrieval (Experiment 2) and search (Experiments 3A–B) tasks, despite acting efficiently in non-playful, instrumental contexts. We discuss the value of such apparently utility-violating behavior and why it might serve learning in the long run.
“The Red Spots Are Now Lava, We Shouldn’t Step on Them”—The Joint Creation of Novel Arbitrary Social Contexts in Pretend Play
Authors: Andrási Krisztina , Király Ildikó
Published: May 2023

Pretend play has been extensively studied in developmental science, nevertheless important questions remain about how children engage in and navigate between pretend episodes. In this proposal, we scrutinize childhood pretense from a social cognitive developmental point of view. First, we review previous theories of pretend play structured around important questions that pinpoint some attributes of pretend episodes, such as their transient and socially defined nature. In these sections, evidence is also reviewed about children’s understanding of these attributes. Following this, we describe a novel proposal of pretend play which extends recent accounts of (pretend) play (Wyman & Rakoczy, 2011; Chu & Schulz, 2020a) by exploiting the importance of social interactions in pretense. We contend that engaging in shared pretending can be considered a manifestation of and support for children’s ability to participate in and set up arbitrary contextual boundaries with others. These claims are discussed with regards to how pretend play may figure into social development, its potential implications for intra- as well as intercultural variation, as well as future research.
Multilingual Language Ideological Assemblages: Language Contact, Documentation and Revitalization
Authors: Kroskrity Paul V.
Published: May 2023

Data from long-term research in two ideologically divergent Native American linguistic communities demonstrate the importance, first, of indigenous multilingualisms and, second, of distinctive ideologies of multilingualism in shaping the divergent language contact outcomes and practices of those communities as they adapted to such forces as economic incorporation, colonization, assimilationist policies, and later decolonization and attempted language revitalization. Indigenous ideological differences in these communities were key factors in producing divergent patterns of language shift as well as in community efforts to document and revitalize their respective heritage languages. The Village of Tewa (NE Arizona) still partially retains a multilingual adaptation in all generations except youth and young adults (Kroskrity, 1993; 2014). The Western Mono (Central California) were traditionally multilingual with neighboring languages of the Yokuts and Southern Sierra Miwok groups (Kroskrity, 2009a). Though both groups were historically multilingual, multilingual practices were differentially influenced by distinctive language ideologies such as those emphasizing purism/syncretism and the expressive/utilitarian functions of language. This observation suggests the importance of understanding indigenous multilingualisms and their consequences for language contact within their language ideological assemblages (Kroskrity, 2018).
Reappraising Survey Tools in the Study of Multilingualism: Lessons From Contexts of Small-Scale Multilingualism
Authors: Di Carlo Pierpaolo
Published: May 2023

Surveys can allow for the collection of non-speech data in a relatively short time and might benefit field linguists working in contexts of language contact. Existing survey models broadly share a basic structure embodying ways of understanding speakers and contexts of interaction that are ultimately derived from diglossia theory. By attempting a critical analysis of the ideological foundations of survey tools, this article provides the opportunity to recognize some key limitations that might affect the diagnostic potential of current survey models in specific contexts. A case in point is offered by Lower Fungom, in rural Cameroon, where forms of non-diglossic, small-scale multilingualism are practiced. Through the presentation of first-hand fieldwork experience and ethnographic data, it becomes apparent that a new model of surveying multilingual populations is needed in order to capture relevant information in such contexts. This article advances some proposals aiming to build such a model. Since its innovations are rooted in sociolinguistic phenomena that appear to be common across environments of small-scale multilingualism, the proposed model can potentially be applied in research conducted in any environments of this kind.
Adapting Methods of Language Documentation To Multilingual Settings
Authors: Good Jeff
Published: May 2023

Commonly recommended methods for documenting endangered languages are built around the assumption that a given documentary project will focus on a single language rather than a multilingual ecology. This hinders the potential usability of documentary materials for the study of language contact. Research in domains such as ethnography and sociolinguistics has developed conceptual and analytical tools for understanding patterns of multilingual usage, but the insights of such work have yet to be translated into concrete recommendations for enhancements to documentary practice. This paper considers how standard documentary approaches can be adapted to multilingual contexts with respect to activities such as the collection of metadata, the use of ethnographic methods, and the recording and annotation of naturalistic multilingual discourse. A particular focus of the discussion are ways in which documentary projects can create better records of multilingual practices even if these are not the focus of the work.
Obsidian Vessels and Eye Inlays from Naqada and Abydos in the Collection of the Garstang Museum, Liverpool, UK
Authors: O’Sullivan Rebecca
Published: May 2023

Nine unpublished obsidian artefacts (one cosmetics jar, two vessel fragments, and six eye inlays) from the Garstang Museum collection are presented, with the aim of patching gaps in the current record concerning their excavation contexts and material properties, which were presumably detailed in John Garstang’s now-lost excavation report/notes. The objects date to the Early Dynastic and Old Kingdom periods, and five objects were matched to those described in previous archival research on Garstang’s Abydos excavations. SEM-EDS was conducted to characterise the material compositions and make a preliminary assessment of the obsidian’s provenance. It is suggested that the obsidian for the three vessels (analyses on prepared surfaces) may have originated in the region of modern Eritrea and Ethiopia, but the eye inlays (non-destructive analyses on raw surfaces) could not be matched to any geological obsidian source, highlighting the difficulties with balancing object preservation and analytical quality in researching museum collections.
Typification of names in Mexican Arundinella (Poaceae, Panicoideae, Arundinelleae)
Authors: VIGOSA-MERCADO J. LUIS
Published: May 2023

N/A
Two new records of Xylariales species from Northern Thailand
Authors: KARIMI OMID , CHETHANA K. W. THILINI , FARIAS ANTONIO R. G. , LI QIRUI
Published: May 2023

Xylariales members have conspicuous to inconspicuous perithecia with unitunicate asci. The most known species are endophytes and saprobes, known to produce secondary metabolites with fundamental importance in the pharmaceutical and chemical industries. The current study collected samples from decaying barks of Quercus kingiana at Doi Inthanon National Park, Thailand. Based on morphological features coupled with combined gene analyses of ITS, LSU, rpb2 and tub2 sequence data, the isolates were identified as Xylaria karsticola and Jackrogersella minutella, belonging to Xylariaceae and Hypoxylaceae, respectively. This study provides the first geographical records of X. karsticola and J. minutella in Thailand and the first records of these species on Quercus kingiana.
Maguirellaria (Caryophyllaceae), a new genus from Dominican Republic
Authors: IAMONICO DUILIO
Published: May 2023

Molecular analyses have shown that Stellaria is a polyphyletic genus and several species are closely related to other genera of Caryophyllaceae. Among the excluded taxa, a group of four species (S. antillana, S. howardii, S. minutifolia, and S. ovata) appear to be not included in the core of Stellaria and are possibly related to the genus Triplateia. Despite this molecular evidence, as well as the morphology of these four species, a formal proposal for a new taxon is still lacking. I here describe the genus Maguirellaria gen. nov., including Maguire’s Stellaria howardii and S. minutifolia. S. antillana and S. ovata, which display a very different morphology in comparison with Maguire’s species, were never considered in the same molecular study; therefore, I prefer to avoid a taxonomic decision for the moment.
Rhamphoriopsis hyalospora sp. nov. associated with decaying wood from China
Authors: LIN CHUAN-GEN , LIU JIAN-KUI , CHUKEATIROTE EKACHAI , HYDE KEVIN D.
Published: May 2023

Rhamphoriopsis hyalospora sp. nov., is described, illustrated and compared with other Rhamphoriopsis species. Evidence for the new species is provided by morphological comparison and molecular data analyses. Rhamphoriopsis hyalospora can be distinguished from other Rhamphoriopsis species by its caespitose conidiophores closely packed together but not forming synnemata, and aseptate, hyaline, ellipsoidal to obovoid, aguttulate conidia.
Description of a geographically variable elongate rock-dwelling cichlid (Cichliformes: Cichlidae) from Lake Malaŵi, Africa
Authors: STAUFFER JAY R. , KONINGS ADRIANUS F.
Published: May 2023

The rock-dwelling cichlids from Lake Malaŵi, known as mbuna, comprise a diverse group of haplochromine fishes that are placed among 14 genera. Within the mbuna, Pseudotropheus is a polyphyletic genus, which has served as a catch-all for many of these fishes. Recently, many of the species-groups within Pseudotropheus have been elevated to separate genera. Herein, we describe an elongate form that was originally placed in the Pseudotropheus elongatus species group but is now described as a member of Metriaclima.
The Politics of Police
Authors: Donahue Samuel Thomas
Published: May 2023

The connection between racially prejudiced policing and politics has a long history in the United States. In the current period, police organizations have displayed unprecedented support for Republican presidential candidates, and both have organized against social movements focused on addressing racial disparities in police contact. Yet despite strong connections between law enforcement and party politics, we know almost nothing about the relationship between partisan identity and the behavior of police officers. Using millions of traffic stop records from the Florida Highway Patrol and linked voter records, the present study shows that White Republican officers exhibit a larger racial disparity than White Democratic officers in their propensity to search motorists whom they have stopped. This result is robust to an array of alternative empirical tests and holds across varying sociodemographic contexts. I also find that both White Republican and White Democratic officers grew more biased between 2012 and 2020, a period characterized by the rise of the Black Lives Matter movement and the election of Donald Trump.
“The homeland is on the ship:” D’Annunzio's La nave and the construction of nationhood
Authors: Guslandi Silvia
Published: May 2023

A fervent nationalist and one of the authors most securely planted at the center of the Italian literary canon, D’Annunzio might not seem the most likely choice when seeking to trouble linguistically and culturally homogenous notions of Italian literary history. And yet, through an analysis of the 1908 play La nave—a work of nationalist propaganda—I argue that D’Annunzio's construction of italianità is the result of a complex negotiation between nationalist politics and a much more hybrid and cosmopolitan cultural ideal. Specifically, I point to the text's fascination with ‘oriental’ aesthetic practices, the general allure of the ‘other,’ its geographically decentered setting, and several structural and stylistic features that I define as ‘textual residues,’ to show that while the affirmation of Italian superiority ultimately takes precedence over representations of hybridity, multiplicity, and foreign influence, D’Annunzio's anxiety over their inclusion is nevertheless the driving force of the play.
No Fixed Limit for Storing Simple Visual Features: Realistic Objects Provide an Efficient Scaffold for Holding Features in Mind
Authors: Chung Yong Hoon , Brady Timothy F. , Störmer Viola S.
Published: May 2023

Prominent theories of visual working memory postulate that the capacity to maintain a particular visual feature is fixed. In contrast to these theories, recent studies have demonstrated that meaningful objects are better remembered than simple, nonmeaningful stimuli. Here, we tested whether this is solely because meaningful stimuli can recruit additional features—and thus more storage capacity—or whether simple visual features that are not themselves meaningful can also benefit from being part of a meaningful object. Across five experiments (30 young adults each), we demonstrated that visual working memory capacity for color is greater when colors are part of recognizable real-world objects compared with unrecognizable objects. Our results indicate that meaningful stimuli provide a potent scaffold to help maintain simple visual feature information, possibly because they effectively increase the objects’ distinctiveness from each other and reduce interference.
Psychiatric nurses’ experience of moral distress: Its relationship with empowerment and coping
Authors: Tomura Michiko
Published: May 2023

Background

Research has shown that moral distress negatively impacts nurses, patients, and organizations; however, several scholars have argued that it can be an opportunity for positive outcomes. Thus, factors that may mitigate moral distress and catalyze positive change need to be explored.

Research aim

The purpose of this study was to explore the relationships among structural and psychological empowerment, psychiatric staff nurses’ experience of moral distress, and strategies for coping with moral distress.

Research design

A descriptive cross-sectional correlational study.

Participants and research context

A total of 180 registered nurses working in psychiatric hospitals in Japan participated. This study examined relationships among key variables using four questionnaires to assess structural and psychological empowerment, moral distress for psychiatric nurses, and coping strategies. Statistical analyses of correlations and multiple regressions were conducted.

Ethical considerations

The study was approved by the institutional review board at the author’s affiliated university.

Findings

Psychiatric nurses perceived moderate levels of structural and psychological empowerment, and their experiences of moral distress were related to low staffing. Structural empowerment was negatively related to the frequency of moral distress but not the intensity. Contrary to expectations, psychological empowerment was not found to mitigate nurses’ moral distress. Multivariate regression analyses revealed that the significant predictors of moral distress were the leaving issues unresolved coping style, the problem-solving coping style, and a lack of formal power, which explained 35% and 22% of the variance in the frequency and intensity of moral distress, respectively.

Conclusions

In psychiatric hospitals in Japan, nurses experience moral distress that compromises the quality of care they provide. Therefore, formal support for nurses in voicing and investigating their moral concerns is required to bestow formal power by establishing a ward culture that includes shared governance.
The Economics of Cryptocurrencies: Finance in Digital Era
Authors: Narula Isha , Dhingra Kriti
Published: May 2023

Global economic markets are encountering apprehensions and susceptibilities after the pandemic of COVID-19. Investment patterns are becoming restrained because of uncertain global scenarios and reduced GDP worldwide. World economies are moving towards digital era and investors are becoming more open towards the newest forms of investments. Due to the uncertain scenarios, investors globally are looking forward to some lucrative forms of investments and cryptocurrencies are the ray of hope for global investors. The present study is attempt to explore the changing dynamics of cryptocurrencies with the market uncertainties. Volatility of five cryptocurrencies, namely Bitcoin, Ethereum, XRP, Chainlink and Bitcoin Cash are analysed using the Generalised AutoRegressive Conditional Heteroskedasticity Model. Results showed that the investors preferred taking cautious decisions and invested more in famous bitcoin rather than other cryptocurrencies.
An Economic Analysis of the Performance of Public Service State Road Transport Undertaking of India: A Case Study of the Haryana Roadways
Authors: Khanoda Neelam , Singh Dara
Published: May 2023

The main objective of public transport is to convey more people in much less space than individual automobiles and help in reducing traffic congestion as well as air pollution from vehicles. It also relieves riders of the stress that come from daily driving in congested areas. The present study took a case study of SRTUs (State Road Transport Undertakings) of Haryana Roadways and found out which factors affect their performance during study periods. It also analyses the performance of traffic and accidents rate in the state. To evaluate the physical and financial performance of the Haryana Roadways LGR (Linear growth rate) and ordinary least square techniques are adopted and the annual average growth of each variable during 2009–2010 to 2017–2018 with the help of SPSS is found. In the financial aspect, the result reveals that Haryana Roadways goes running into a loss environment. The physical aspects revealed that fleet utilisation, vehicle utilisation, or load factor are decreased and negatively affect the physical performance of Haryana Roadways, but Staff productivity or effective kilometre per day contributes to a positive trend. The findings suggest that appropriate policy initiatives or operational research are required for these undertakings to be transformed into profit-making SRTUs in India.
Capturing Image–Text Modal Relations in Mobile Instant Messaging Through WhatsApp Diaries
Authors: Apte Deepti Singh , Upadhyay Ashwani Kumar
Published: May 2023

Polymedia chat applications such as WhatsApp are facilitating ‘mixed-media’ relationships (Parks, 2017, Communication Research, 4, 505) as they have penetrated our everyday mediated interactions. This has led to calls for a deeper probe into the interconnections of the varied modes. After defining its vital term ‘mode’, the current study focuses on two widely used modes—image and text—in everyday mediated interactions via chat applications. In order to study their interconnections, the study adopts Martinec’s (2005) image–text relation systems. The findings indicate two extreme range points of image–text interconnections in mediated chat app-based interactions. At one extreme point, images and texts seem to be repeating each other’s messages, and at another point, they seem to complement one another. The point where images and texts complement one another highlights the role of images, and the point seems to play evocative and facilitative roles.
Femicide in Mexico. Who Are the Slain Women According to News Media? A Quantitative Study of Social Representations of Victims and Perpetrators
Authors: Aldrete Mariana
Published: May 2023

Research on femicide news revealed discriminatory narratives against the victims in specific cases and social contexts. This article uses a quantitative approach to analyze the news content that serves to create social representations of victims and perpetrators. We propose a methodology based on examining independent elements in the descriptions, identifying extratextual patterns, and providing the data to compare the social representations of intimate partner violence (IPV), familiar, and non-IPV femicides. Three online news outlets were analyzed from July 2014 to December 2017, creating a corpus of 2,527 articles. The results revealed that it is more common to create negative representations of victims than negative representations of the perpetrators.