bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern hardware accelerated point based holography
Authors: Fricke Sascha , Caspary Reinhard , Castillo Susana , Eisemann Martin , Magnor Marcus
Published: June 2024

This paper presents a novel method for accelerating the computationally intensive process of point-based holography using consumer grade hardware. By leveraging the parallel processing capabilities of graphics processing units (GPUs) and implementing optimization techniques, the proposed method significantly reduces the time required to generate complex holograms. A comprehensive analysis – including benchmarks and comparative studies – demonstrates the efficiency and effectiveness of this approach. Our findings offer promising implications for real-time applications in virtual reality, and other fields that require rapid and accurate holographic rendering.
Infection patterns in simple and complex contagion processes on networks
Authors: Contreras Diego Andrés , Cencetti Giulia , Barrat Alain
Published: June 2024

Contagion processes, representing the spread of infectious diseases, information, or social behaviors, are often schematized as taking place on networks, which encode for instance the interactions between individuals. The impact of the network structure on spreading process has been widely investigated, but not the reverse question: do different processes unfolding on a given network lead to different infection patterns? How do the infection patterns depend on a model’s parameters or on the nature of the contagion processes? Here we address this issue by investigating the infection patterns for a variety of models. In simple contagion processes, where contagion events involve one connection at a time, we find that the infection patterns are extremely robust across models and parameters. In complex contagion models instead, in which multiple interactions are needed for a contagion event, non-trivial dependencies on models parameters emerge, as the infection pattern depends on the interplay between pairwise and group contagions. In models involving threshold mechanisms moreover, slight parameter changes can significantly impact the spreading paths. Our results show that it is possible to study crucial features of a spread from schematized models, and inform us on the variations between spreading patterns in processes of different nature.
Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement
Authors: Du Wei , Verma Adya , Ye Qianlin , Du Wen , Lin Sandy , Yamanaka Atsushi , Klein Ophir D. , Hu Jimmy K.
Published: June 2024

The development of ectodermal organs begins with the formation of a stratified epithelial placode that progressively invaginates into the underlying mesenchyme as the organ takes its shape. Signaling by secreted molecules is critical for epithelial morphogenesis, but how that information leads to cell rearrangement and tissue shape changes remains an open question. Using the mouse dentition as a model, we first establish that non-muscle myosin II is essential for dental epithelial invagination and show that it functions by promoting cell-cell adhesion and persistent convergent cell movements in the suprabasal layer. Shh signaling controls these processes by inducing myosin II activation via AKT. Pharmacological induction of AKT and myosin II can also rescue defects caused by the inhibition of Shh. Together, our results support a model in which the Shh signal is transmitted through myosin II to power effective cellular rearrangement for proper dental epithelial invagination.
Re-assessing thermal response of schistosomiasis transmission risk: Evidence for a higher thermal optimum than previously predicted
Authors: Aslan Ibrahim Halil , Pourtois Julie D. , Chamberlin Andrew J. , Mitchell Kaitlyn R. , Mari Lorenzo , Lwiza Kamazima M. , Wood Chelsea L. , Mordecai Erin A. , Yu Ao , Tuan Roseli , Palasio Raquel Gardini Sanches , Monteiro Antônio M. V. , Kirk Devin , Athni Tejas S. , Sokolow Susanne H. , N’Goran Eliezer K. , Diakite Nana R. , Ouattara Mamadou , Gatto Marino , Casagrandi Renato , Little David C. , Ozretich Reed W. , Norman Rachel , Allan Fiona , Brierley Andrew S. , Liu Ping , Pereira Thiago A. , De Leo Giulio A.
Published: June 2024

The geographical range of schistosomiasis is affected by the ecology of schistosome parasites and their obligate host snails, including their response to temperature. Previous models predicted schistosomiasis’ thermal optimum at 21.7°C, which is not compatible with the temperature in sub-Saharan Africa (SSA) regions where schistosomiasis is hyperendemic. We performed an extensive literature search for empirical data on the effect of temperature on physiological and epidemiological parameters regulating the free-living stages of S. mansoni and S. haematobium and their obligate host snails, i.e., Biomphalaria spp. and Bulinus spp., respectively. We derived nonlinear thermal responses fitted on these data to parameterize a mechanistic, process-based model of schistosomiasis. We then re-cast the basic reproduction number and the prevalence of schistosome infection as functions of temperature. We found that the thermal optima for transmission of S. mansoni and S. haematobium range between 23.1–27.3°C and 23.6–27.9°C (95% CI) respectively. We also found that the thermal optimum shifts toward higher temperatures as the human water contact rate increases with temperature. Our findings align with an extensive dataset of schistosomiasis prevalence in SSA. The refined nonlinear thermal-response model developed here suggests a more suitable current climate and a greater risk of increased transmission with future warming for more than half of the schistosomiasis suitable regions with mean annual temperature below the thermal optimum.
Uncovering the genetic diversity and adaptability of Butuo Black Sheep through whole-genome re-sequencing
Authors: Huang Zengwen , Wang Jing , Qi Dongming , Li Xiaoyan , Wang Jinkang , Zhou Jingwen , Ruan Yan , Laer Youse , Baqian Zhangjia , Yang Chaoyun
Published: June 2024

The Butuo Black Sheep (BBS) is well-known for its ability to thrive at high altitudes, resist diseases, and produce premium-quality meat. Nonetheless, there is insufficient data regarding its genetic diversity and population-specific Single nucleotide polymorphisms (SNPs). This paper centers on the genetic diversity of (BBS). The investigation conducted a whole-genome resequencing of 33 BBS individuals to recognize distinct SNPs exclusive to BBS. The inquiry utilized bioinformatic analysis to identify and explain SNPs and pinpoint crucial mutation sites. The findings reveal that reproductive-related genes (GHR,FSHR,PGR,BMPR1B,FST,ESR1), lipid-related genes (PPARGC1A,STAT6,DGAT1,ACACA,LPL), and protein-related genes (CSN2,LALBA,CSN1S1,CSN1S2) were identified as hub genes. Functional enrichment analysis showed that genes associated with reproduction, immunity, inflammation, hypoxia, PI3K-Akt, and AMPK signaling pathways were present. This research suggests that the unique ability of BBS to adapt to low oxygen levels in the plateau environment may be owing to mutations in a variety of genes. This study provides valuable insights into the genetic makeup of BBS and its potential implications for breeding and conservation efforts. The genes and SPNs identified in this study could serve as molecular markers for BBS.
Roseiterribacter gracilis gen. nov., sp. nov., a novel filterable alphaproteobacterium isolated from soil using a gel-filled microwell array device
Authors: Nakai Ryosuke , Kusada Hiroyuki , Sassa Fumihiro , Makino Ayaka , Morigasaki Susumu , Hayashi Hisayoshi , Takaya Naoki , Tamaki Hideyuki
Published: June 2024

Our previous studies indicate the abundant and diverse presence of yet-to-be-cultured microorganisms in the micropore-filtered fractions of various environmental samples. Here, we isolated a novel bacterium (designated as strain TMPK1T) from a 0.45-μm-filtered soil suspension by using a gel-filled microwell array device comprising 900 microwells and characterized its phylogenetic and physiological features. This strain showed low 16S rRNA gene sequence identities (<91%) and low average nucleotide identity values (<70%) to the closest validly described species, and belonged to a novel-family-level lineage within the orderRhodospirillalesofAlphaproteobacteria. Strain TMPK1Texhibited small cell sizes (0.08–0.23 μm3) and had a high cyclopropane fatty acid content (>13%), and these characteristics were differentiated from otherRhodospirillalesbacteria. A comprehensive habitability search using amplicon datasets suggested that TMPK1Tand its close relatives are mainly distributed in soil and plant-associated environments. Based on these results, we propose that strain TMPK1Trepresents a novel genus and species namedRoseiterribacter gracilisgen. nov., sp. nov. (JCM 34627T= KCTC 82790T). We also proposeRoseiterribacteraceaefam. nov. to accommodate the genusRoseiterribacter.
A qualitative exploration of the over-the-counter availability of oral contraceptive pills in Australia
Authors: Ahmed Zobaida , Gu Yuanyuan , Sinha Kompal , Mutowo Mutsa , Gauld Natalie , Parkinson Bonny
Published: June 2024

Introduction

The prevention of unintended pregnancy is a public health issue affecting women worldwide. In Australia, women are required to get a prescription to obtain the oral contraceptive pill (OCP), which may limit access and be a barrier to its initiation and continuing use. Changing the availability of the OCP from prescription-only to over-the-counter (OTC) is one solution, however, to ensure success policymakers need to understand women’s preferences. Telehealth services also might serve as an alternative to obtain prescriptions and increase accessibility to OCPs. This study aims to explore the preferences for OTC OCPs among Australian women, and whether the expansion of telehealth impacted women’s preferences.

Methods

A mixed methods approach was used to explore women’s preferences regarding access to the OCP. Focus group discussions (FGDs) were conducted to organically identify the preferences followed by an empirical ranking exercise. Three FGDs in two phases were conducted, pre and post-expansion of telehealth in Australia due to the COVID-19 pandemic. Convenience sampling was employed. The technique of constant comparison was used for thematic analysis where transcripts were analysed iteratively, and codes were allowed to emerge during the process to give the best chance for the attributes to develop from the data.

Results

Thematic analysis revealed that women perceived OTC availability of OCPs as a mechanism to increase the accessibility of contraception by reducing cost, travel time, waiting time, and increasing opening hours. They also believed that it would increase adherence to OCPs. However, some potential safety concerns and logistical issues were raised, including pharmacist training, access to patient’s medical history, the ability to discuss other health issues or undertake opportunistic health screening, adherence to checklists, and privacy in the pharmacy environment. Following the expansion of telehealth, accessibility issues such as opening hours, travel time, and location of the facility were considered less important.

Conclusions

The participants expressed their support for reclassifying OCPs to OTC, particularly for repeat prescriptions, as it would save valuable resources and time. However, some safety and logistical issues were raised. Women indicated they would balance these concerns with the benefits when deciding to use OTC OCPs. This could be explored using a discrete choice experiment. The expansion of telehealth was perceived to reduce barriers to accessing OCPs. The findings are likely to be informative for policymakers deciding whether to reclassify OCPs to OTC, and the concerns of women that need addressing to ensure the success of any policy change.
The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine
Authors: Chen Xiaorui , Mohapatra Arpita , Nguyen Hong Thuy Vy , Schimanski Lisa , Kit Tan Tiong , Rijal Pramila , Chen Cheng-Pin , Cheng Shu-Hsing , Lee Wen-Hsin , Chou Yu-Chi , Townsend Alain R. , Ma Che , Huang Kuan-Ying A.
Published: June 2024

Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals and elucidate the mechanism of action of broadly neutralizing antibodies and dissect antibodies at the epitope level. The breadth and clonality of anti-RBD B cell response varies among individuals. The majority of neutralizing antibody clones lose or exhibit reduced activities against Beta, Delta, and Omicron variants. Nevertheless, a portion of anti-RBD antibody clones that develops after a primary series or booster dose of COVID-19 vaccination exhibit broad neutralization against emerging Omicron BA.2, BA.4, BA.5, BQ.1.1, XBB.1.5 and XBB.1.16 variants. These broadly neutralizing antibodies share genetic features including a conserved usage of the IGHV3-53 and 3–9 genes and recognize three clustered epitopes of the RBD, including epitopes that partially overlap the classically defined set identified early in the pandemic. The Fab-RBD crystal and Fab-Spike complex structures corroborate the epitope grouping of antibodies and reveal the detailed binding mode of broadly neutralizing antibodies. Structure-guided mutagenesis improves binding and neutralization potency of antibody with Omicron variants via a single amino-substitution. Together, these results provide an immunological basis for partial protection against severe COVID-19 by the ancestral strain-based vaccine and indicate guidance for next generation monoclonal antibody development and vaccine design.
Roger Ackling: Stillness as a drawing method
Authors: Hughes Dean
Published: June 2024

From 1974 until 2014 the British Artist Roger Ackling made drawings on found pieces of driftwood by using the sun’s rays focused through a magnifying glass. This research article discusses the contribution Ackling made to charting an ontology of drawing through a practice of stillness. By employing this method, he provides an original contribution to the knowledge base of drawing that values ephemerality and lightness through phenomenological bracketing. An evaluation is provided as to how Roger Ackling dwells upon and makes subject the precise moment of making in drawing.
THE APPLICABILITY OF TOPIC MODELING TO IDENTIFY ACTORS OF SOCIO-POLITICAL MOBILIZATION USING LOW-CODE ANALYTICAL PLATFORMS
Authors: Stepanov Ivan Yu. , Kranzeeva Elena A. , Golovatsky Evgeny V. , Donova Inna V. , Burmakina Anna L.
Published: June 2024

The article presents a contemporary perspective on the analysis of socio-political processes, grounded in the premise that the application of topic modeling through low-code platforms can substantially enhance the quality of research performed by analysts. This enhancement is particularly significant in identifying the pivotal actors and the evolving dynamics within socio-political processes. The authors argue that topic modeling, a relatively novel approach compared to traditional methods, is capable of uncovering relationships and trends that might otherwise remain obscured. In advocating for this approach, the paper proposes an integrated methodology. This methodology is designed to empower researchers in the social sciences, enabling them to effectively utilize these innovative tools. The objective is to deepen their comprehension of the underlying mechanisms that drive socio-political mobilization. To substantiate their argument, the authors present various case studies. These case studies demonstrate the effectiveness of topic modeling in revealing otherwise hidden connections among various actors. Additionally, they illustrate how topic modeling sheds light on the contributions of these actors to the dynamics of mobilization. This approach represents a significant advancement in the field, offering new insights and a more nuanced understanding of complex socio-political landscapes.
¿Españolas en el trabajo sexual? Rutas de movilidad
Authors: Meneses Falcón Carmen
Published: June 2024

En este trabajo se explora la movilidad de las españolas para el trabajo sexual a Suiza, especialmente a la ciudad de Ginebra. Se analizan los motivos que les llevan a trasladarse a otro país, el desarrollo del trabajo sexual y la posible existencia de procesos de explotación o coacción. Se ha realizado un trabajo etnográfico en la ciudad de Ginebra, recogiendo observaciones y entrevistas a trabajadoras sexuales españolas, a dueños y encargados de negocios del sexo y a miembros de una ONG. Los resultados obtenidos se relacionan con las condiciones de seguridad y beneficios que las trabajadoras sexuales pueden obtener en esta movilidad, así como las políticas y actuaciones en el trabajo sexual que se desarrollan en ambos países.
Familias transnacionales en contexto de crisis. Movilidad y (no) arreglos familiares de venezolanos en Perú
Authors: Cavagnoud Robin
Published: June 2024

Desde 2016, América Latina es el escenario de un fenómeno migratorio masivo de venezolanos que abandonan su país para sobrevivir a la crisis. Estas migraciones, en su mayoría individuales, conducen a la creación de familias transnacionales, que se caracterizan por un sistema de solidaridad a distancia entre el país de destino y Venezuela. Este artículo explora la formación, los arreglos y los modos de organización de estas familias. A partir de entrevistas retrospectivas con 51 migrantes venezolanos de ambos sexos asentados en Perú, se analizan las distintas formas de familia transnacional y los límites en la observación de este concepto. Además de la transferencia de dinero y de la comunicación entre migrantes y no migrantes, se destacan dos configuraciones de este tipo de familia, en relación con la urgencia de hacer frente a la inseguridad alimentaria y con los proyectos de otros miembros familiares en este espacio de movilidad regional.
Exploring rice genotypes for anaerobic germination: Towards sustainable direct seeding
Authors: Vijaya Kumar Reddy C , P Ranjith. , Panda Siddharth , Dash Manasi , A Anandan , D Lenka , K.C Samal. , R.K Panda.
Published: June 2024

Direct-seeded rice (DSR) production is the primary focus of this study, which explores the diversity of rice genotypes concerning their ability to withstand anaerobic germination conditions. Using advanced statistical analysis, a total of 250 rice cultivars were assessed for several anaerobic germination attributes. Significant variability was observed among genotypes for key traits including germination % (ARC14855, AG 387), shoot length and seedling dry weight, indicating potential donors for anaerobic germination tolerance. Trait association analysis, variability analysis, principal component analysis and cluster analysis were employed to uncover the genetic and phenotypic factors influencing anaerobic germination tolerance. The genotypes of cluster III could be used as donors for anaerobic germination studies, as the genotypes have revealed high average values for all the traits. The findings underscore the importance of genetic variability and heritability in breeding resilient rice varieties suited for DSR cultivation, offering valuable insights for enhancing rice cultivation practices in the face of challenges such as water scarcity and labour shortages. To improve the sustainability and productivity of paddy production systems, this research advances rice breeding procedures that aim to create varieties tolerant to anaerobic conditions.
Will Proclaimed Changes to Multinationals’ Taxation Have an Actual Effect and What Will Really Change for Africa?
Authors: Musselli Andrea
Published: June 2024

The article is a comment to Conceptualising the behaviour of MNEs, Tax Authorities and Tax Consultants in respect of transfer pricing practices. A three-layer analysis, by Wealth, Smulders, and Mpofu. The latter deals with transfer pricing but in the African perspective while the most part of articles frequently analyze the issue from the point of view of most developed and OECD (Organisation for Economic Co-operation and Development) countries. The paper focuses on the qualities of the commented article and proposes a resume on the state of art of the complex recent reforms of transfer pricing rules disposed by the OECD.
The colexification of vision and cognition in Mandarin: controlled activity surpasses uncontrolled experience
Authors: Dai Ying , Wu Yicheng
Published: June 2024

Given the colexification of perception and cognition, Georgakopoulos et al. (2022. Universal and macro-areal patterns in the lexicon: A case-study in the perception-cognition domain. Linguistic Typology 26(2). 439–487) claim that uncontrolled experience rather than controlled activity has a direct linkage to cognition. To test whether this is a universal tendency, this study conducts a contrastive behavioral profile analysis of two basic vision verbs in Mandarin: kàn, a controlled activity verb, and jiàn, an uncontrolled experience verb. The results show that (i) both kàn and jiàn colexify visual activity and cognitive senses; (ii) kàn is able to express a wider range of cognitive meanings, i.e., know, understand, and think, whereas jiàn only extends into know; and (iii) visual and cognitive meanings have more proximal relationships in the colexification pattern of kàn than that of jiàn. The study confirms the universality of the colexification between vision and cognition while providing counterexamples to the above-mentioned large data-based findings. Accordingly, a dichotomy of controlled activity versus uncontrolled experience is proposed for the colexification of vision and cognition in cognitive typology.
Invisibility and Hypervisibility: Rabindranath Tagore and His Self-Translated English Works in the Western World
Authors: Liu Xiaoqing
Published: June 2024

Translation inherently involves grappling with cultural, power, and knowledge dynamics. It encompasses the shaping of ideas by those in control and the influence of translation on the perception of cultures, peoples, and texts. While translation can empower marginalized voices, it may also reinforce power imbalances by favoring dominant languages and cultures in colonial contexts. Translation is a crucial instrument in shaping, reflecting, and challenging global power dynamics. Lawrence Venuti classifies translation strategies into domestication and foreignization, associating the former with Anglo-American hegemony and the latter as a challenge to Western cultural dominance. He suggests that these strategies result in different outcomes for translators’ visibility: domesticating translators go unnoticed, while foreignizing translators emerge from obscurity. However, the translation practices in colonial and postcolonial contexts demonstrate that Venuti’s binary categories may oversimplify the complexities of translation activities. Rabindranath Tagore’s self-translation from Bengali into English complicates Venuti’s theory, as both domesticating and foreignizing translations coexist. Tagore, as a translator, and his English audiences engage in both strategies. His foreignization goal, introducing Indian culture to the West, is achieved through domesticating his poetry for acceptance. Simultaneously, his English readers adopt both approaches, connecting Tagore’s writing to the English literary tradition while exoticizing differences. This results in Tagore transitioning from invisibility to hypervisibility, but within two decades, he fades into obscurity in the Western world. Tagore’s experience underscores that pursuing visibility exclusively or relying solely on foreignizing translation strategy cannot effectively challenge Western hegemony. Instead, efforts should be made to safeguard against the pervasive influence of imperial power in the cultural exchange between the non-Western (English-speaking) world and the West (English-speaking world).
Timelike zero mean curvature surfaces in ℝ1
4
Authors: Kaya Seher
Published: June 2024

We are interested in the solution of the Björling problem for timelike surfaces in

R
1
4

\mathbb{R}_{1}^{4}

.
The main contribution of the paper is to present new and many examples of timelike zero mean curvature surfaces and give their explicit parametric equations.
In particular cases, one observes that the parametric equations of these surfaces coincide with the timelike minimal surfaces in Lorentz–Minkowski 3-space.
Effect of perforated wall in controlling the separation due to SWBLI at Mach no. 5 to 9
Authors: Babu R Dinesh , Joshi Ganapati N. , Chandel Sunil , Mishra Ranjan Kumar
Published: June 2024

The mixed compression scramjet engine intake was numerically simulated to study the characteristic of shock wave induced boundary layer separation leading to the formation of the separation bubble (SB). The analysis employed a 2D-RANS method with SST k-ω turbulence model at different Mach numbers. The intake is designed as a three-ramp intake for improved performance. As the Mach number varies, the size of the separation bubble formed due to the interaction of oblique shock waves with the boundary layer also varies, affecting both intake the efficiency and overall efficiency of the engine. Apart from traditional control techniques, the most preferred bleed technique is incorporated. Localised & distributed bleed techniques are designed and analysed within the intake at different locations. These techniques result in a reduction in the size of the separation bubble within the intake. Establishing perforation in the engine intake also increases the intake efficiency and overall engine performance.
Reported Personality Traits and Histories of Childhood Maltreatment in Borderline Personality Disorder and Bipolar 2 Disorder: A Comparative Study
Authors: Reich D. Bradford , Gatchell Jalan , Lovell-Smith Nathaniel , Ren Boyu , Zanarini Mary C.
Published: June 2024

This study compared borderline personality disorder (BPD) and bipolar 2 disorder (BP 2 disorder) with respect to reported childhood trauma and Five-Factor personality traits using the Childhood Trauma Questionnaire (CTQ) and the NEO Five-Factor Inventory (NEO-FFI). Participants were 50 men and women, aged 18-45, with DSM-5-diagnosed BPD and 50 men and women in the same age group with DSM-5-diagnosed BP 2 disorder. Participants could not meet criteria for both BPD and BP 2 disorder. Borderline participants had significantly higher scores on the neuroticism subscale and significantly lower scores on the agreeableness subscale of the NEO-FFI. After correction for multiple comparisons, there were no between-group differences on CTQ scores. Study results suggest that BPD and BP 2 disorder differ primarily with respect to underlying temperament/genetic architecture and that environmental factors have only a limited role in the differential etiologies of the two disorders.
A rare case of pulmonary complication after laparoscopic sleeve gastrectomy in an obese patient, associated with central venous catheter malposition: a case report
Authors: Paraskeva Aikaterini , Kefalou Eirini , Triantafyllidis Alexandros , Drakopoulos Vasileios
Published: June 2024

Introduction: Surgical intervention for morbid obesity possesses a first-line treatment and it is widespread worldwide. Obese patients have a high chance of postoperative complications and mortality is significantly raised with higher BMI levels. In addition to this, the altered anatomy of obese patients characterizes the central venous catheter insertion as a difficult procedure. Case presentation: In our case report we present a 52-year-old woman who admitted in our surgical department in order to be treated surgically for morbid obesity. All of her preoperative evaluation tests were absolutely normal. The patient was treated with laparoscopic sleeve gastrectomy. On postoperative day 2 the patient presented with acute dyspnea and low oxygen saturation. Diagnosis: After evaluation with computed tomography of the thorax an excessive right pleural effusion was diagnosed and the patient was treated with thoracic tube insertion. There was a fully recovery and the patient discharged after a couple of days. Conclusion: High mortality and morbidity after laparoscopic sleeve gastrectomy is a crucial parameter for postoperative complications in obese patients. High suspicion and wide spectrum of differential diagnosis results in early prevention and solution of the problem.
Mental health of pregnant women: modern realities
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Poladich I.V. , Govsieiev D.O. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: June 2024

This review provides data on the impact of the war in Ukraine and the COVID-19 pandemic on the mental health of Ukrainian women during pregnancy, childbirth, and the postpartum period. It is noted that even in peacetime, the perinatal period is quite vulnerable. The aim of the study is to analyze the impact of post-traumatic stress disorder (PTSD) on the course of pregnancy, childbirth and the postpartum period. According to statistics, one in five women may have a perinatal mental disorder. In today's realities, mental health is given considerable attention. Mental health disorders, such as depression, anxiety and PTSD, manifested by negative thoughts, loss of interest and/or pleasure, fatigue and/or increased anxiety, are the most common diagnoses. It is clear that pregnancy and the postpartum period, although they can be joyful, are also times of stress and difficulty for mothers as they face physiological and psychosocial changes. Particular attention is paid to the connection of maternal depression and anxiety with an increase in inflammatory biomarkers in the mother during pregnancy, which is associated with an increased risk of neurodevelopment in children. Despite the contradictory results of the hypothesis about fetal programming, it is important to recognize that caring for the mother and the child are interconnected. Pregnant mothers who have PTSD are at increased risk of premature termination of pregnancy and premature birth, the development of preeclampsia, gestational diabetes, and other obstetric and perinatal losses. A review of the literature confirms the relevance of studying the impact of PTSD on the perinatal period, since timely diagnosis and treatment of mental disorders is a key element of preserving the health of pregnant women and ensuring the stable development of the nation. The authors declare no conflict of interest.
Management of women with cervical insufficiency - transformation of views
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Narytnyk T.T. , Burka O.A. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: June 2024

Cervical cerclage is an obstetric procedure used to prevent late term spontaneous abortions and preterm birth in women at high risk of miscarriage. Taking into consideration existance of insufficient effectiveness of methods for preventing spontaneous preterm labor, as evidenced by the lack of significant changes in statistical data over the past 10 years, further research is needed to improve the tactics of managing pregnant women, especially from the group of high risk of this complication. Cervical cerclage allows to mechanically stop the process of spontaneous opening of the cervix, however, although the method is minimally invasive, when using it, there is still a risk of complications, such as infection or trauma to the cervix. Taking this into account, determining the groups of patients who will benefit the most from this intervention is essential. Today, this issue is undergoing a number of transformations and updates which we tried to analyze in this work. Aim - determining changes in the recommendations for surgical management of women with isthmico-cervical insufficiency based on the analysis of the latest recommendations of the National Institute for Health and Care Excellence and the Royal College of Obstetricians and Gynecologists. Results and conclusions. According to the 2022 guidelines, along with slightly changed approaches to the classification and terminology of cervical cerclage, there has been some transformation in views about the groups of women who will benefit the most from the procedure. First of all, according to anamnestic data, cervical suture is recommended for three anamnestic episodes of miscarriage instead of two in the previous recommendations. On ultrasound examination, a wedge-shaped transformation of the cervix and incidental detection of cervical shortening after 20 weeks is not an indication for applying a cerclage, since the effectiveness of the intervention in this case is unproven. In addition, new techniques, such as abdominal cerclage, have been invented to more effectively prevent episodes of miscarriage. No conflict of interests was declared by the authors.
Assessment of the impact of gynecological pathology on the chances of life birth of patients with recurrent implantation failure
Authors:   Dnipro State Medical University, Ukraine, Kozyra O.S. , Medvediev M.V. ,   Dnipro State Medical University, Ukraine
Published: June 2024

Aim - to study the prognostic impact of the presence of gynecological pathology on live birth in women with multiple negative implantation attempts in the context of the proposed methods of examination and treatment, such as preimplantation genetic diagnosis of embryos and individualization of the endometrial preparation protocol, taking into account the results of the assessment of the implantation window. Materials and methods. The prospective cohort study included 93 women with infertility treated by in vitro fertilization (IVF). Patients had repeated failed implantation attempts and were divided into three groups: the Group 1 - patients who were treated with genetically untested embryos according to a standard fixed stimulation protocol, the Group 2 - patients who were treated with euploid embryos after preimplantation genetic screening according to a standard fixed protocol; the Group 3 - patients treated with euploid embryos after preimplantation genetic screening and determination of the implantation window with subsequent modification of the stimulation protocol, according to the results of the endometrial examination. The implantation window was determined by three-time aspiration biopsy of the endometrium during the luteal phase of the menstrual cycle. The samples were analyzed by scanning electron microscopy. Based on the results, the endometrial preparation protocol was individualized for the next IVF attempt. Preimplantation diagnostics of embryos was performed using the next generation method. Statistical analysis was performed using IBM SPSS V25.0 for Windows software. Results. According to the results obtained, the presence of genital pathology reduced the chance of live birth by 30% in patients with repeated failed implantation attempts. Pathologies such as endometriosis, including endometrioid ovarian cysts, benign breast disease and Asherman syndrome have a negative effect on the chance of live birth among patients who have undergone infertility treatment with IVF. Conclusions. The presence of gynecologic pathology reduces the chances of live birth in patients with repeated failed implantation attempts undergoing IVF treatment. The study was conducted in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee for all participants. Informed consent was obtained from the patients. No conflict of interests was declared by the authors.
Comparison of functional outcomes and quality of life after surgical treatment of stress urinary incontinence in women
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Chaika K.V. , Bohadelnikova K.I. ,   Shupyk National Healthcare University of Ukraine, Kyiv
Published: June 2024

Sling surgery is a modern and effective surgical treatment for stress urinary incontinence in women. However, there is insufficient data on the comparative analysis of long-term results and quality of life of patients after various options of such operations. Purpose - to compare the functional results and quality of life of women after two variants of sling operations for stress urinary incontinence. Materials and methods. 84 women with stress urinary incontinence were examined, who were divided into two groups. In the Group I, a plastic free synthetic loop (TVT) was performed, in the Group II - an operation using the transobturator location of the prolene loop (TVT-Obturator - TVT-О). Functional outcomes of treatment and quality of life were assessed 2 years after surgery using the ICIQ-SF questionnaire, the Patient General Impression of Improvement (PGI-I) scale, and the Patient Satisfaction Scale. An objective indicator was the absence of leakage of urine during a cough test. Results. Treatment effectiveness, according to objective criteria, was 87.9% and 67.9% 2 years after TVT and TVT-O surgery, respectively (p=0.045). When evaluating subjective indicators, no statistically significant differences between groups were found, however, according to the ICIQ-SF questionnaire, the frequency of improvement in the quality of life was reliably 1.3 times higher in the case of using the TVT technique (odds ratio 3.33; 95% confidence interval 1.14-9.78). The frequency of urinary incontinence recurrence did not depend on the method of sling operation (p>0.05). Data analysis was carried out using The Statistical Package for Social Sciences. Conclusions. When evaluating the results of treatment 2 years after the intervention, the effectiveness of TVT surgery, according to objective criteria, is statistically significantly higher than the effectiveness of TVT-O surgery, although the latter technique is associated with the absence of bladder etching. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Іmmunological features in pregnant women with major obstetric syndromes
Authors:   State higher educational institution Uzhhorod National University, Ukraine, Lemish N.Y.
Published: June 2024

Aim of the research – to evaluate the adaptive capabilities of the immunological system in pregnant women who had complications from the group of major obstetric syndromes (МОS) for the further development of an algorithm for the prevention of this complication. Materials and methods. The main study group (MG) - 99 pregnant women who had a complication from the group of MOS, which was clinically manifested by placental insufficiency (PI); control group (CG) - 50 practically healthy pregnant women with a healthy reproductive history and an uncomplicated course of this pregnancy. The number (x109/l) and relative (%) of lymphocyte subpopulations CD3+ (T-lymphocytes), CD4+ (helper-inducers), CD8+ (cytotoxic suppressors), CD56+ (natural killers), CD19+ (B-lymphocytes) were determined; the presence of antiphospholipid antibodies (APA); total hemolytic activity of the classical way of complement activation (CH50); levels of IgG, IgM, IgA. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistical 6.0 programs. Results. In the I and II trimesters of pregnancy in MG and CG, a tendency to decrease was observed, СM4+ (51.8±2.5% and 48.9±1.6; 58.4±2.3% and 55.6±2.6%), and СD8+ (24.6±2.4% and 21.2±1.2%; 31.3±2.5% and 30.9±2.7%), which led to an increase in the immunoregulatory index (СD4+/СD8+) in MG (р<0.05). The level of СD19+, during gestation there was an increase in their relative number in MG (13.6±0.98%; 16.4±2.03% and 21.1±2.01%) (p<0.05); a predominance of the percentage of CD56+ lymphocytes, which have the properties of natural killers, was observed in pregnant MG (12.3±1.7%; 15.1±1.7%; 13.9±1.73% vs. 8.6±1.4%; 8.1±1.18%; 7.2±0.98%; p<0.05). Hemolytic activity of the classical pathway of complement activation (CH50) in MG pregnant women was 1.5 times higher compared to CG pregnant women (p<0.05). APA, represented by IgG to cardiolipin, were detected in 47 (47.5%) pregnant women MG and 4 (8.0%) women pregnant CG (p<0.05). Conclusions. Іn pregnant women with МОS, there is an immune maladaptation that progressively increases in the dynamics of gestation and is manifested by excessive activation of natural killers (CD56+), an increase in the immunoregulatory coefficient (CD4+/CD8+), an increase in the percentage of B-lymphocytes (CD19+), dysimmunoglobulinemia, which is accompanied by high indicators of the general hemolytic activity of the classical pathway of complement activation (CH50), the presence of APA. The research was conducted according to principles of Declaration of Helsinki. Protocol of research was proved by local ethical committee, mentioned in institution’s work. A informed sonsennt was collected in order to carry out the research. The author is stating no conflict of interests is declared.
The influence of artificial abortions on the reproductive health state of fertile women. Results of a cohort study
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Bodashevska K.D.
Published: June 2024

Data on the negative impact of artificial abortions in the early stages on a woman's reproductive health are contradictory. Variables that may affect the results include study design, gestational age at the time of abortion, duration of follow-up, and procedure’s type. Aim - to analyze the impact of early artificial abortions on the reproductive womenʼs health. Materials and methods. A retrospective cohort study was conducted, which included 549 consecutively recruited women, of which: 119 respondents with a history of induced abortions made up the experimental group, 430 without artificial termination of pregnancy - the comparison group. An analysis of the gynecological and obstetrical anamnesis was carried out. Statistical data processing was carried out using the SPSS 21 program. Results. It was established that the presence of artificial abortions in the anamnesis is associated with an increase in the frequency of infertility, colpitis, cervix dysplasia, salpingo-oophoritis, uterus inflammatory diseases, habitual miscarriage, and also increase in the obstetric complications frequency (spontaneous miscarriages at an early stage, the threat of termination of pregnancy, premature births, abdominal surgical delivery, placental complications). Conclusions. Analysis of the artificial abortions consequences indicates the presence of various disorders in reproductive system of fertile women. This study did not involve any experiments on animals or humans. No conflict of interests was declared by the authors.
Evaluation of the influence of perioperative support of women with morbid obesity on their quality of life
Authors:   Dnipro State Medical University, Ukraine, Duka R.V. , Bereznitsky Ya.S. ,   Dnipro State Medical University, Ukraine, Duka Yu.M. ,   Dnipro State Medical University, Ukraine
Published: June 2024

Aim - to assess eating disorders (ED) in female patients who are candidates for bariatric surgery (BS) and to establish psychological features of the course of the postoperative period in them. Materials and methods. The nature of ED disorders in 51 women with morbid obesity (MO) and accompanying metabolic syndrome (MS), aged from 22 to 55 years, who underwent BS was analyzed. Women with a higher body mass (BMI) underwent biliopancreatic bypass (BPS) in the Hess–Marceau modification (the group I - 21 women), patients with a lower body mass index (BMI) - sleeve gastrectomy (SG) - the group II (30 female patients). The duration of observation in the postoperative period ranged from 3 to 7 years. The BMI of women ranged from 29.2 to 62.1 kg/m2 and averaged 44.0±1.0 kg/m2. The experience of obesity varied from 5 to 21 years. A diagnostic interview using the Dutch Eating Behavior Questionnaire (DEBQ) was performed to assess ED. With the help of the questionnaire "Life satisfaction index (LSI) test (adaptation by N.V. Panina)" the degree of psychological comfort of women was assessed. Results. The average age of patients in the group I was 37.9±2.1 years, in the group II - 41.3±1.7 of the year. 20 (39.2%) women each had external eating behavior (EB) and emotiogenic disorder of EB, of which 5 (25%) cases showed a combination of external and emotiogenic EB. Compulsive EB disorder was registered in 4 (7.8%) cases of emotogenic EB disorder, "night eating" syndrome - in 16 (80%) out of 20. Restrictive EB disorder was found in 16 (31.4%) patients. In 6 (11.8%) cases, this type of ED replaced external ED. All these patients noted the fact of dietary depression. In 45 (88.2%) cases, patients had a score below 25 points, which indicated low life satisfaction; and only in 6 (11.8%) cases it was about average satisfaction. In all 6 (11.8%) cases, we were talking about women with BMI < 40 kg/m2. Conclusions. In patients with obesity, anxiety-neurotic tendencies and psychosocial maladjustment, relatively low tolerance to stress is revealed. Food, in their case, serves as a tool to fight anxiety and depression and further closes the "vicious circle" of obesity. During the initial survey, special attention should be paid to the attitude of the patient with MO to alcohol, because alcohol addiction is a contraindication for performing BPS. The indicator of the "Index of satisfaction with life" directly correlates with the indicators of a woman's body weight. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Reputation System as a Digital Socio-Economic Institution: Willingness to Sell in Online Markets
Authors: Elfena Lisa
Published: June 2024

This study examines the features and big data consisting of digital trace records from economic actions within Bukalapak's reputation system and their impact on the willingness to sell (WTS) electronic products. Digital mixed content analysis was used to analyze the rapidly evolving digital-social-based economic institution infrastructure. Data were collected, analyzed, and visualized using Python and analyzed using the concepts of new economic institutions and WTS. The findings indicate that the reputation system is a formal element comprising algorithms, rules, scripts, and patterns. This system facilitates social processes through feedback mechanisms in product descriptions, comments, reviews, ratings, and badges, which generate informal elements such as norms, trust, and symbolic values. These two elements are interconnected into an institutional framework whose function is to ensure that the market, characterized by high levels of anonymous transactions, uncertainty, and asymmetric information, can remain stable and meet the expectations of the actors involved.