bluuebunny/crossref_metadata_2025 huggingface dataset:
PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses
Authors: Sarkar Bhattacharya Sayantani , Thirusangu Prabhu , Jin Ling , Roy Debarshi , Jung Deokbeom , Xiao Yinan , Staub Julie , Roy Bhaskar , Molina Julian R. , Shridhar Viji
Published: September 2019

The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a critical control point in the glycolytic pathway, decreases glucose uptake, ATP production, and lactate dehydrogenase activity and arrests malignant pleural mesothelioma (MPM) cells in the G0/G1 phase to induce cell death. To overcome this nutrient stress, inhibition of PFKFB3 activity led to an escalation in endoplasmic reticulum (ER) activity and aggravated ER stress mostly by upregulating BiP and GADD153 expression and activation of the endocytic Rac1-Rab5-Rab7 pathway resulting in a unique form of cell death called “methuosis” in both the sarcomatoid (H28) and epithelioid (EMMeso) cells. Transmission electron microscopy (TEM) analysis showed the formation of nascent macropinocytotic vesicles, which rapidly coalesced to form large vacuoles with compromised lysosomal function. Both immunofluorescence microscopy and co-immunoprecipitation analyses revealed that upon PFKFB3 inhibition, two crucial biomolecules of each pathway, Rac1 and Calnexin interact with each other. Finally, PFK158 alone and in combination with carboplatin-inhibited tumorigenesis of EMMeso xenografts in vivo. Since most cancer cells exhibit an increased glycolytic rate, these results provide evidence for PFK158, in combination with standard chemotherapy, may have a potential in the treatment of MPM.
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study
Authors: Kogure Mana , Hirata Takumi , Nakaya Naoki , Tsuchiya Naho , Nakamura Tomohiro , Narita Akira , Miyagawa Ken , Koshimizu Hiroshi , Obara Taku , Metoki Hirohito , Uruno Akira , Kikuya Masahiro , Sugawara Junichi , Kuriyama Shinichi , Tsuji Ichiro , Kure Shigeo , Hozawa Atsushi
Published: September 2019

Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13–1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.
Structural puzzles in virology solved with an overarching icosahedral design principle
Authors: Twarock Reidun , Luque Antoni
Published: September 2019

Viruses have evolved protein containers with a wide spectrum of icosahedral architectures to protect their genetic material. The geometric constraints defining these container designs, and their implications for viral evolution, are open problems in virology. The principle of quasi-equivalence is currently used to predict virus architecture, but improved imaging techniques have revealed increasing numbers of viral outliers. We show that this theory is a special case of an overarching design principle for icosahedral, as well as octahedral, architectures that can be formulated in terms of the Archimedean lattices and their duals. These surface structures encompass different blueprints for capsids with the same number of structural proteins, as well as for capsid architectures formed from a combination of minor and major capsid proteins, and are recurrent within viral lineages. They also apply to other icosahedral structures in nature, and offer alternative designs for man-made materials and nanocontainers in bionanotechnology.
Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery
Authors: Modi Souvik , López-Doménech Guillermo , Halff Elise F. , Covill-Cooke Christian , Ivankovic Davor , Melandri Daniela , Arancibia-Cárcamo I. Lorena , Burden Jemima J. , Lowe Alan R. , Kittler Josef T.
Published: September 2019

Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are essential machinery for the regulated trafficking of mitochondria to defined subcellular locations. However, their sub-mitochondrial localization and relationship with other critical mitochondrial complexes remains poorly understood. Here, using super-resolution fluorescence microscopy, we report that Miro proteins form nanometer-sized clusters along the mitochondrial outer membrane in association with the Mitochondrial Contact Site and Cristae Organizing System (MICOS). Using knockout mouse embryonic fibroblasts we show that Miro1 and Miro2 are required for normal mitochondrial cristae architecture and Endoplasmic Reticulum-Mitochondria Contacts Sites (ERMCS). Further, we show that Miro couples MICOS to TRAK motor protein adaptors to ensure the concerted transport of the two mitochondrial membranes and the correct distribution of cristae on the mitochondrial membrane. The Miro nanoscale organization, association with MICOS complex and regulation of ERMCS reveal new levels of control of the Miro GTPases on mitochondrial functionality.
Author Correction: Novel multilayer TiO2 heterojunction decorated by low g-C3N4 content and its enhanced photocatalytic activity under UV, visible and solar light irradiation
Authors: Wang Yizheng , Yu Jiang , Peng Weidong , Tian Jing , Yang Chun
Published: September 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Predictions of the mechanical properties of unidirectional fibre composites by supervised machine learning
Authors: Pathan M. V. , Ponnusami S. A. , Pathan J. , Pitisongsawat R. , Erice B. , Petrinic N. , Tagarielli V. L.
Published: September 2019

We present an application of data analytics and supervised machine learning to allow accurate predictions of the macroscopic stiffness and yield strength of a unidirectional composite loaded in the transverse plane. Predictions are obtained from the analysis of an image of the material microstructure, as well as knowledge of the constitutive models for fibres and matrix, without performing physically-based calculations. The computational framework is based on evaluating the 2-point correlation function of the images of 1800 microstructures, followed by dimensionality reduction via principal component analysis. Finite element (FE) simulations are performed on 1800 corresponding statistical volume elements (SVEs) representing cylindrical fibres in a continuous matrix, loaded in the transverse plane. A supervised machine learning (ML) exercise is performed, employing a gradient-boosted tree regression model with 10-fold cross-validation strategy. The model obtained is able to accurately predict the homogenized properties of arbitrary microstructures.
Domain and Switching Control of the Bulk Photovoltaic Effect in Epitaxial BiFeO3 Thin Films
Authors: Knoche David S. , Yun Yeseul , Ramakrishnegowda Niranjan , Mühlenbein Lutz , Li Xinye , Bhatnagar Akash
Published: September 2019

Absence of inversion symmetry is the underlying origin of ferroelectricity, piezoelectricity, and the bulk photovoltaic (BPV) effect, as a result of which they are inextricably linked. However, till now, only the piezoelectric effects (inverse) have been commonly utilized for probing ferroelectric characteristics such as domain arrangements and resultant polarization orientation. The bulk photovoltaic effect, despite sharing same relation with the symmetry as piezoelectricity, has been mostly perceived as an outcome of ferroelectricity and not as a possible analytical method. In this work, we investigate the development of BPV characteristics, i.e. amplitude and angular dependency of short-circuit current, as the ferroelastic domain arrangement is varied by applying electric fields in planar devices of BiFeO3 films. A rather sensitive co-dependency was observed from measurements on sample with ordered and disordered domain arrangements. Analysis of the photovoltaic response manifested in a mathematical model to estimate the proportion of switched and un-switched regions. The results unravel the potential utility of BPV effect to trace the orientation of the polarization vectors (direction and amplitude) in areas much larger than that can be accommodated in probe-based techniques.
Nano-fibre Integrated Microcapsules: A Nano-in-Micro Platform for 3D Cell Culture
Authors: Khanal Shalil , Bhattarai Shanta R. , Sankar Jagannathan , Bhandari Ramji K. , Macdonald Jeffrey M. , Bhattarai Narayan
Published: September 2019

Nano-in-micro (NIM) system is a promising approach to enhance the performance of devices for a wide range of applications in disease treatment and tissue regeneration. In this study, polymeric nanofibre-integrated alginate (PNA) hydrogel microcapsules were designed using NIM technology. Various ratios of cryo-ground poly (lactide-co-glycolide) (PLGA) nanofibres (CPN) were incorporated into PNA hydrogel microcapsule. Electrostatic encapsulation method was used to incorporate living cells into the PNA microcapsules (~500 µm diameter). Human liver carcinoma cells, HepG2, were encapsulated into the microcapsules and their physio-chemical properties were studied. Morphology, stability, and chemical composition of the PNA microcapsules were analysed by light microscopy, fluorescent microscopy, scanning electron microscopy (SEM), Fourier-Transform Infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The incorporation of CPN caused no significant changes in the morphology, size, and chemical structure of PNA microcapsules in cell culture media. Among four PNA microcapsule products (PNA-0, PNA-10, PNA-30, and PNA-50 with size 489 ± 31 µm, 480 ± 40 µm, 473 ± 51 µm and 464 ± 35 µm, respectively), PNA-10 showed overall suitability for HepG2 growth with high cellular metabolic activity, indicating that the 3D PNA-10 microcapsule could be suitable to maintain better vitality and liver-specific metabolic functions. Overall, this novel design of PNA microcapsule and the one-step method of cell encapsulation can be a versatile 3D NIM system for spontaneous generation of organoids with in vivo like tissue architectures, and the system can be useful for numerous biomedical applications, especially for liver tissue engineering, cell preservation, and drug toxicity study.
Effects of Model, Method of Collection, and Topography on Chemical Elements and Metals in the Aerosol of Tank-Style Electronic Cigarettes
Authors: Williams Monique , Li Jun , Talbot Prue
Published: September 2019

Our purpose was to examine the effect of model, puffing topography (voltage, air-flow, puff interval), and method of collection on 19 elements/metals in aerosols from six tank-style electronic cigarettes (EC). Aerosols were collected from six brands using a cold trap or impinger and various puffing topographies. 19 elements were quantified using inductively coupled plasma optical emission spectroscopy. 16 elements/metals were present and quantified in the aerosols. The total concentrations of elements/metals ranged from 43 to 3,138 µg/L with the impinger method of collection and 226 to 6,767 µg/L with the cold trap method. The concentrations of individual elements were often similar across brands and across topographies. Some elements (e.g., zinc) were present in most aerosols, while others (e.g., cadmium, titanium, vanadium) were rarely found. Concentrations of some elements (e.g., lead) increased in aerosols as voltage/power increased. The model with fewest metal parts in the atomizer had the fewest metals in its aerosols. Most elements/metals in the aerosols have been found previously in the atomizers of EC. All tank-style aerosols had elements/metals that appeared to originate in the atomizers, and concentrations increased with increasing power. Concentrations of some elements were high enough to be a health concern.
Feeding Dimorphism in a Mycophagous Nematode, Bursaphelenchus sinensis
Authors: Kanzaki Natsumi , Ekino Taisuke , Giblin-Davis Robin M.
Published: September 2019

Phenotypic plasticity has been widely reported in animals and can drive investment in new biological characters that engender ecological adaptability. The nematode family Diplogastridae, especially Pristionchus pacificus with its dramatic stomatal (feeding) dimorphism, has become an important model system to analyze the evolutionary and developmental aspects of polyphenism. However, this plasticity has not been confirmed in other nematode groups. In the present study, we experimentally examined the feeding dimorphism of a fungal feeding free-living nematode, Bursaphelenchus sinensis. In a laboratory culturing experiment, the nematode expressed dimorphism, i.e., a small proportion of the population manifested as a predatory form. This form only occurred in females and was not clearly influenced by the presence of potential prey species. In addition, the ratio of the predatory form to the mycophagous form varied among different fungal food species grown in monoculture on different culture media. The predatory form of B. sinensis was typologically similar to the monomorphic (specialized) predators belonging to the same family. However, some essential morphological characters were slightly different from the specialized predators, and their behaviours were clearly disparate, suggesting that predation in B. sinensis is derived from a different phylogenetic origin than that of the specialized predators.
A miniaturized electrochemical platform with an integrated PDMS reservoir for label-free DNA hybridization detection using nanostructured Au electrodes
Authors: Tripathy Suryasnata , Joseph Jose , Pothuneedi Saketh , Das Dhruv , Vanjari Siva Rama Krishna , Rao A. V. S. S. Narayana , Singh Shiv Govind
Published: September 2019

We report the fabrication and characterization of a miniaturized electrochemical platform for the label-free detection of DNA hybridization.
A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells
Authors: Li Zilu , Yu Chen , Chen Yanan , Zhuang Zihan , Tian Bin , Liu Caiyun , Jia Pan , Zhu Hanchuang , Sheng Wenlong , Zhu Baocun
Published: September 2019

A water-soluble fluorescent probe with ultra-sensitivity over a wider pH range was developed to differentiate cancer cells from normal cells.
A HPLC-MS method for profiling triterpenoid acids and triterpenoid esters in Osmanthus fragrans fruits
Authors: Liao Xiaoyan , Hu Fangli , Chen Zilin
Published: September 2019

An effective and sensitive HPLC-MS method for profiling 31 triterpenoid acids and triterpenoid esters in Osmanthus fragrans fruits.
A fluorescent probe based on aggregation-induced emission for hydrogen sulfide-specific assaying in food and biological systems
Authors: Xu Lingfeng , Ni Ling , Sun Lihe , Zeng Fang , Wu Shuizhu
Published: September 2019

An AIE-based fluorescent probe was developed for monitoring food spoilageviaits response toward hydrogen sulfide.
Potentiometric analysis of sialic acid with a flexible carbon cloth based on boronate affinity and molecularly imprinted polymers
Authors: Zhou Yanli , Huangfu Huijie , Yang Jie , Dong Hui , liu Lantao , Xu Maotian
Published: September 2019

A potentiometric sensor for sialic acid detection was designed based on a boronic acid-containing MIP modified carbon cloth electrode.
A carbon dot-based fluorescent nanoprobe for the associated detection of iron ions and the determination of the fluctuation of ascorbic acid induced by hypoxia in cells and in vivo
Authors: Huang Yan , He Na , Kang Qi , Shen Dazhong , Wang Xiaoyan , Wang Yunqing , Chen Lingxin
Published: September 2019

The fluorescent nanoprobe CD-DB complexation with iron ions was used to determine the fluctuation of ascorbic acid induced by hypoxia in living cells, zebrafish and mice.
Discriminative potential of ion mobility spectrometry for the detection of fentanyl and fentanyl analogues relative to confounding environmental interferents
Authors: Forbes Thomas P. , Lawrence Jeffrey , Verkouteren Jennifer R. , Verkouteren R. Michael
Published: September 2019

Receiver operating characteristic (ROC) curve framework was employed to investigate the trace detection of fentanyl and fifteen fentanyl-related compounds relative to environmental background interferents.
Determination of phenolic compounds in alcoholic fermentation materials and spent grains by ultrasound-assisted alkali alcohol extraction coupled with HPLC
Authors: Wu Ziyang , He Fei , Qin Dan , Li Hehe , Sun Jinyuan , Sun Xiaotao , Sun Baoguo
Published: September 2019

The characteristics of five phenolic compounds in alcoholic fermentation materials and spent grains were evaluated by employing ultrasound-assisted alkali alcohol extraction coupled with high-performance liquid chromatography (HPLC).
Tunable optical absorption in lead-free perovskite-like hybrids by iodide management
Authors: Kou Bo , Zhang Weichuan , Ji Chengmin , Wu Zhenyue , Zhang Shuhua , Liu Xitao , Luo Junhua
Published: September 2019

Tunable optical absorption in lead-free perovskite-like hybrids by iodide management.
First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria
Authors: Lesur Emilie , Baron Aurélie , Dietrich Christiane , Buchotte Marie , Doisneau Gilles , Urban Dominique , Beau Jean-Marie , Bayan Nicolas , Vauzeilles Boris , Guianvarc’h Dominique , Bourdreux Yann
Published: September 2019

In this study we describe the first synthesis of an alkyne-based trehalose monomycolate probe closely mimicking the complex pattern of mycolic acids and its utility for the study of mycomembrane and mycoloyltransferases in Corynebacteria.
Mitochondrial heat shock protein-guided photodynamic therapy
Authors: Thomas Ajesh P. , Lee An-Jung , Palanikumar L. , Jana Batakrishna , Kim Kibeom , Kim Sangpil , Ok Haewon , Seol Jihoon , Kim Dongseok , Kang Byoung Heon , Ryu Ja-Hyoung
Published: September 2019

Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT).
5.1% efficiency of Si photoanodes for photoelectrochemical water splitting catalyzed by porous NiFe (oxy)hydroxide converted from NiFe oxysulfide
Authors: Zhou Wanyi , Fan Ronglei , Hu Taozheng , Huang Guanping , Dong Weng , Wu Xi , Shen Mingrong
Published: September 2019

Highly efficient and stable Si photoanodes catalyzed by porous NiFe (oxy)hydroxide converted from NiFe oxysulfide for photoelectrochemical water splitting.
Rhodium catalyzed C–C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates and analogs
Authors: Yang Xuan , Kong Wei-Yu , Gao Jia-Ni , Cheng Li , Li Nan-Nan , Li Meng , Li Hui-Ting , Fan Jun , Gao Jin-Ming , Ouyang Qin , Xie Jian-Bo
Published: September 2019

The tandem “conjugate addition/β-C cleavage/protonation” process (CCP) is reported.
A nano AuTiO2−x composite with electrochemical characteristics of under-potential deposition of H (H-UPD) as a highly efficient electrocatalyst for hydrogen evolution
Authors: Ren Zhandong , Jin Lingzhi , Gao Jie , Chen Hanruo , Zhai Conghui , Tan Lingjun , Cong Ning , Fang Hua , Zhou Xiaorong , Zhu Yuchan
Published: September 2019

A nano AuTiO2−x composite with the electrochemical characteristics of under-potential deposition of H has exhibited excellent activity for hydrogen evolution.
A fivefold linker length reduction in an interpenetrated metal–organic framework via sequential solvent-assisted linker exchange
Authors: Cao Li-Hui , Liu Xin , Tang Xiao-Han , Liu Junyi , Xu Xiao-Qian , Zang Shuang-Quan , Ma Yang-Min
Published: September 2019

Sequential transformations lead to a more than five times reduction in linker size, which is the largest change by SALE.
Anisotropic photogenerated charge separations between different facets of a dodecahedral α-Fe2O3 photocatalyst
Authors: Wang Conghui , Zhu Chuanming , Ren Xiaobo , Shi Jing , Wang Liancheng , Lv Baoliang
Published: September 2019

Hematite (α-Fe2O3) is regarded as one of the most promising photocatalysts, but its photocatalytic activities have always been limited to the pristine form because of poor charge separation efficiency.
Hyperfine tensors for a model system for the oxygen evolving complex of photosystem II: calculation of the anisotropy shift that occurs beyond the strong exchange limit
Authors: Mehlich Christine , van Wüllen Christoph
Published: September 2019

Broken-symmetry density functional calculations have been used to calculate effective 55Mn hyperfine (A) tensors for a mixed-valence tetranuclear manganese complex, a model system for the S2 state of the oxygen-evolving complex of photosystem II.
Formation mechanism and spectroscopy of C6H radicals in extreme environments: a theoretical study
Authors: Chin Chih-Hao , Zhu Tong , Zhang John Zeng Hui
Published: September 2019

Franck–Condon calculations of C6H radical predict optical transitions in the spectral region of a gas phase.
A generalized solid strengthening rule for biocompatible Zn-based alloys, a comparison with Mg-based alloys
Authors: Guo Yuanqi , Zhang Shihao , Wei Bo , Legut Dominik , Germann Timothy C. , Zhang Haijun , Zhang Ruifeng
Published: September 2019

A general strategy for designing biocompatible Zn-based alloys by means of the ab initio informed Peierls–Nabarro model and solid-solution strengthening model.
Mechanistic insights into artificial metalloenzymes towards imine reduction
Authors: Feng Haisong , Guo Xuan , Zhang Hui , Chen Lifang , Yin Pan , Chen Chunyuan , Duan Xinli , Zhang Xin , Wei Min
Published: September 2019

The anchoring effect of artificial metalloenzymes determines the chirality of the product of imine reduction.
Designing rare earth free permanent magnets: insights from small Co clusters
Authors: Sen Arpita , Sen Prasenjit
Published: September 2019

With the ultimate goal of rational design of rare earth free permanent magnets, microscopic origins of large MAE in Co4 clusters doped with group 14 and 15 elements are investigated using DFT.
Accurate K-edge X-ray photoelectron and absorption spectra of g-C3N4 nanosheets by first-principles simulations and reinterpretations
Authors: Zhang Jun-Rong , Ma Yong , Wang Sheng-Yu , Ding Junfei , Gao Bin , Kan Erjun , Hua Weijie
Published: September 2019

Accurate N1s and C1s XPS spectra of g-C3N4 were obtained by a combined cluster-periodic approach and we make new assignments.
Graphene-covered transition metal halide molecules as efficient and durable electrocatalysts for oxygen reduction and evolution reactions
Authors: Zhang Detao , Zhang Jing , Gong Lele , Zhu Yonghao , Zhang Lipeng , Xia Zhenhai
Published: September 2019

Graphene-covered halides are designed as durable and efficient electrocatalysts in acid media. A design principle has been established through the DFT calculations, from which the best catalysts could be predicted for fuel cells.
Synthesis, X-ray structure, photophysical properties, and theoretical studies of six-membered cyclometalated iridium(iii) complexes: revisiting Ir(pnbi)2(acac)
Authors: Yamada Kie , Mori Hirotoshi , Sugaya Tomoaki , Tadokoro Makoto , Maeba Junichi , Nozaki Koichi , Haga Masa-aki
Published: September 2019

For the cyclometallation reaction with the polyaromatic ligand to Ir(N^C) complexes, the steric bulkiness determines whether the six-membered or five-membered N^C metallocycle is formed.
Enhanced removal of antibiotics in hospital wastewater by Fe–ZnO activated persulfate oxidation
Authors: Coulibaly Gnougon Nina , Bae Sungjun , Kim Joohyun , Assadi Aymen Amin , Hanna Khalil
Published: September 2019

A recirculation reactor system using an Fe-doped zinc oxide supported membrane and UV-A irradiation was designed to remove fluoroquinolones in hospital wastewaters.
Path integral methods for reaction rates in complex systems
Authors: Lawrence Joseph E. , Manolopoulos David E.
Published: September 2019

We shall use this introduction to the Faraday Discussion on quantum effects in complex systems to review the recent progress that has been made in using imaginary time path integral methods to calculate chemical reaction rates.
Time-resolved imaging of atoms and molecules in laser-produced uranium plasmas
Authors: Kautz E. J. , Skrodzki P. J. , Burger M. , Bernacki B. E. , Jovanovic I. , Phillips M. C. , Harilal S. S.
Published: September 2019

Spatial temporal contours of atoms and molecules in uranium plasmas reveal complex plasma–chemical interaction between plume and oxygen-containing ambient gas.
Review on pneumatic operations in centrifugal microfluidics
Authors: Hess J. F. , Zehnle S. , Juelg P. , Hutzenlaub T. , Zengerle R. , Paust N.
Published: September 2019

The combination of pneumatic and centrifugal forces enables robust automation of multistep biochemical workflows. We review technical implementations on microfluidic cartridges and discuss the design of pneumatic unit operations within two tutorials.
Subphthalocyanine-based conjugated porous polymers for efficient singlet oxygen generation
Authors: Xu Qian , Gao Ying , Wu Xiaofu , Hang Hao , Li Hua , Chen Yonghong , Wang Weijie , Tong Hui
Published: September 2019

Subphthalocyanine-based conjugated porous polymers can efficiently absorb long-wavelength photons to generate singlet oxygen rapidly.
FeOCl/Ln (Ln = La or Y): efficient photo-Fenton catalysts for ibuprofen degradation
Authors: Shi Xiaohua , Cui Chao , Zhang Lei , Zhang Jian , Liu Guodong
Published: September 2019

Doping of rare earth elements (La and Y) in FeOCl boosted the Fenton catalytic activity under sunlight.
Mesoporous polymeric catalysts with both sulfonic acid and basic amine groups for the one-pot deacetalization−Knoevenagel reaction
Authors: Sun Zunming , Yang Xinyue , Huang Xianpei , Zhang Mengmeng , Bian Guomin , Qi Yonglin , Yang Xinlin , Zhang Wangqing
Published: September 2019

Acid–base bifunctional P(DVB–NH2–n-SO3H) catalysts with mesoporous structure have been prepared and characterized for a one-pot cascade reaction with good recycling properties.
A water soluble light activated hydrogen sulfide donor induced by an excited state meta effect
Authors: Bera Manoranjan , Maji Somnath , Paul Amrita , Ray Souvik , Maiti Tapas Kumar , Singh N. D. Pradeep
Published: September 2019

A light activated water soluble H2S donor based on an m-amino benzyl chromophore operated by an excited state “meta effect”.
A convenient approach for the preparation of imidazo[1,2-a]-fused bicyclic frameworks via IBX/NIS promoted oxidative annulation
Authors: Makra Zsófia , Puskás László G. , Kanizsai Iván
Published: September 2019

IBX/NIS induced intramolecular oxidative cyclization of Mannich substrates is reported, affording highly diverse imidazo[1,2-a]-pyridines, -pyrimidines and -pyrazines in up to 93% isolated yield. In addition, one-pot procedure is also represented.
Syntheses of doubly linked proanthocyanidins using free flavan units as nucleophiles: insight into the origin of the high regioselectivity of annulation
Authors: Betkekar Vipul V. , Harachi Mio , Suzuki Keisuke , Ohmori Ken
Published: September 2019

Reported herein is a viable synthesis route to procyanidins A1 and A2, doubly linked flavan dimers. The use of nascent nucleophilic partner, catechin or epicatechin, enabled facile regioselective annulation with an ethylenedioxy-bridged flavan unit.
Microstructures, thermophysical properties and thermal cycling behavior of LaZnAl11O19 thermal barrier coatings deposited by atmospheric plasma spraying
Authors: Liu Fan , Song Wenjia , Zhou Xin , Huo Panjie , Yuan Jieyan , Jiang Jianing , Deng Longhui , Dong Shujuan , Cao Xueqiang
Published: September 2019

Considering its low thermal conductivity, excellent sintering resistance and thermal cycling lifetime, LaZnAl11O19 might be a promising candidate for TBCs.
Reagent-controlled regiodivergence in the [3,3]-sigmatropic rearrangement ofN-(acyloxy)enamides
Authors: Takeda Norihiko , Arisawa Narumi , Miyamoto Misaki , Kobori Yukiko , Shinada Tetsuro , Miyata Okiko , Ueda Masafumi
Published: September 2019

A regiodivergent [3,3]-sigmatropic rearrangement ofN-(acyloxy)enamides based on the N–O bond cleavage is achieved by changing reaction conditions.
Retraction: A miraculous chiral Ir–Rh bimetallic nanocatalyst for asymmetric hydrogenation of activated ketones
Authors: Xue Xiuru , Zhao Zhaohui , Wang Yanhua
Published: September 2019

Retraction of ‘A miraculous chiral Ir–Rh bimetallic nanocatalyst for asymmetric hydrogenation of activated ketones’ by Xiuru Xue et al., Org. Chem. Front., 2018, 5, 3585–3589.
Metal-free C–C bond formation via coupling of nitrile imines and boronic acids
Authors: Livingstone Keith , Bertrand Sophie , Mowat Jenna , Jamieson Craig
Published: September 2019

Photochemical generation of nitrile imine species and subsequent reaction with boronic acid derivatives furnishes a new C–C bond without transition metal catalysis.
Self-triggered click reaction in an Alzheimer's disease model:in situbifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques
Authors: Du Zhi , Yu Dongqin , Du Xiubo , Scott Peter , Ren Jinsong , Qu Xiaogang
Published: September 2019

Accumulated Cu in amyloid-β plaques can effectively catalyze the azide–alkyne cycloaddition reaction for fluorophore activation and drug synthesis. Our work may provide new insight intoin situdrug synthesis for neurodegenerative diseases.
Anomalous behavior and structure of a liquid of particles interacting through the harmonic-repulsive pair potential near the crystallization transition
Authors: Levashov Valentin A. , Ryltsev Roman , Chtchelkatchev Nikolay
Published: September 2019

The temperature expansion coefficient of a single-component harmonic-repulsive model system exhibits water-like anomalies at certain pressures.
Promoting polysulfide conversion by catalytic ternary Fe3O4/carbon/graphene composites with ordered microchannels for ultrahigh-rate lithium–sulfur batteries
Authors: Ding Meng , Huang Shaozhuan , Wang Ye , Hu Junping , Pam Mei Er , Fan Shuang , Shi Yumeng , Ge Qi , Yang Hui Ying
Published: September 2019

A MOF-derived Fe3O4/carbon/graphene ordered aerogel is synthesised as a Li–S battery electrode for ultrahigh rate performance with high sulfur loading.
Depth-dependent oxygen redox activity in lithium-rich layered oxide cathodes
Authors: Naylor Andrew J. , Makkos Eszter , Maibach Julia , Guerrini Niccolò , Sobkowiak Adam , Björklund Erik , Lozano Juan G. , Menon Ashok S. , Younesi Reza , Roberts Matthew R. , Edström Kristina , Islam M. Saiful , Bruce Peter G.
Published: September 2019

Energy-tuned photoelectron spectroscopy demonstrates the surface preferential oxidation of oxygen for the Li-rich cathode material Li1.2Ni0.2Mn0.6O2 upon charge.
Amorphous InGaZnO and metal oxide semiconductor devices: an overview and current status
Authors: Troughton Joe , Atkinson Del
Published: September 2019

This review covers the history, development, and state of the art, of metal oxide-based electronics, with particularly focus of indium-gallium-zinc-oxide.
Correction: Fast synthesis of iridium(iii) complexes with sulfur-containing ancillary ligand for high-performance green OLEDs with EQE exceeding 31%
Authors: Lu Guang-Zhao , Tu Zhen-Long , Liu Liang , Zhang Wen-Wei , Zheng You-Xuan
Published: September 2019

Correction for ‘Fast synthesis of iridium(iii) complexes with sulfur-containing ancillary ligand for high-performance green OLEDs with EQE exceeding 31%’ by Guang-Zhao Lu et al., J. Mater. Chem. C, 2019, 7, 7273–7278.
Method for environmental impact assessment of human-induced small-medium activities: the case study of wood biomass supply chain
Authors: Clerico Marina , Bo Matteo , Pognant Federica
Published: September 2019

Climate change evolution, joined by other environmental issues, will lead in the coming years to a rapid introduction of new actions and technologies. They will have to resolve, in the different economic sectors, one or more aspects of the current unsustainability. The relevant risk is that, in urgent conditions where the unreleased practices will be proposed, the assessment of their environmental impact will remain limited to their specificfield/sector. Therefore, the evaluation would not be extended to any wide-ranging environmental effects. Withoutan accurate assessment it would be impossible to determine whether the solution was more damaging and burdensometo the environment than the initial problem. Small-medium anthropic activities do not possess, from the economicpoint of view, the means and the duty to achieve an impact analysis ad hoc. This work aims to describe an analysis methodology developed for the environmental impact assessment of Small-Medium Enterprises. It is both exhaustive and easily applicable to small work activities and processes. This methodology is aimed both at business managers and at local authorities. The identified method of analysis allows an exhaustive evaluation of the whole forest energy chain and the identification of technical choice with less impact on the environment.
Energy communities
Authors: Tartaglia Angelo
Published: September 2019

Energy communities are associations of producers and consumers of energy set up to reduce the dependence on fossil fuels and optimise the use of energy for the advantage of the members. This paper presents an experiment being implemented in the territory around the town of Pinerolo in western Piedmont. Encouraging results are reported.
Towards sustainable ICT
Authors: Meo Michela
Published: September 2019

While information and communication technologies (ICT) can play a crucial role in tackling issues related to sustainability, and reducing resource consumption in every sector, they also consume huge amounts of energy, andthis, combined with the predicted rapid growth of demand for communication services, is expected to make the whole sector more and more energy-hungry in the coming years. The sustainability of ICT itself is also becoming an urgent challenge. Actions can be taken in several directions: i) introducing a massive and pervasive use of renewable energy sources, a step that requires the design of communication services to be revised; ii) enforcing rules and policies that induce the provisioning of sustainable services and promote the adoption of proper attitudes; and iii) involving the users who will become conscious consumers and participate in crowdsourcing projects tomonitor consumption and foster energy-aware behaviours.
An integrated approach to energy use: the case study of the ACEA site
Authors: Negro Viviana , Mainero Davide
Published: September 2019

Currently, ACEA utilises biogas obtained from the treatment of the organic fraction of municipal solid waste for thermal and electric energy recovery through endothermic engines (3 MW, in total). By 2020, the biogas produced at the site will no longer be used as a fuel for the combined heat and power units, but it is expected to feed a purification system in order to obtain a flow of biomethane to be injected into the natural gas network. This is part of the Italian strategy to achieve the Horizon 2020 European targets aimed at promoting the renewable production of transport fuels. In order to encourage sustainability and innovative prototype technologies, ACEA has also been involved in some European research projects, in particular for the conversion of biogas into other energy carriers. furthermore, ACEA ha recently built a flexible experimental platform that can used for the validation step of prototypes in an industrial field.
A Study on Protective Reuse of Traditional Architecture in Lhasa
Authors: Qin Qing , Chen Yang , Zhang Haiyue
Published: September 2019

Traditional Tibetan architecture in Lhasa has a unique position in the world. Under the special social background of economic development demand and tourism, it has gradually become a pillar industry, and how to rationally protect and reuse this traditional architecture has become an urgent problem that must be solved. Based on the traditional architectural patterns, regional characteristics and modern needs of Lhasa, this paper discusses the strategies for the protection and reuse of architectural heritage, the specific methods of reuse and their advantages and disadvantages, in order to provide a reference for the protection of traditional buildings and the inheritance of culture in Tibet.
Study on Stability and Reliability of NOx Ultra-low emission in Coal-fired Power Plants in China
Authors: Zhang Yang , Xin Xiaoying , Hu Da , Zhu Wentao , Zhu Yue
Published: September 2019

Along with the rapid progress of flue gas ultra-low emission reconstruction in coal-fired power plants in recent years, the stability and reliability problems in the operation of the project have emerged, among which the denitrification problem is the most acute. Given the present situation of the NOx ultra-low emission in coal-fired power plants, several typical problems about stability and reliability have been analyzed and discussed, including flow fields uniformity, low load denitrification, in-line meter accuracy, catalyst life on the basis of extensive and thorough investigation. Relevant guidance and countermeasures are proposed to provide further reference for the following denitrification projects and operations.
Chorioangiom der Plazenta – eine seltene Ursache fetaler High-Output-Herzinsuffizienz
Authors: Ziemann Miriam , Apostolidou Sofia , Dum David , Hecher Kurt , Singer Dominique , Tavares de Sousa Manuela
Published: September 2019

Plazentare Chorangiome sind als benigne Tumore des Choriongewebes seltene Ursache fetaler und maternaler Morbidität. Wir beschreiben den Fall eines großen plazentaren Chorangioms, das zu einem Polyhydramnion, konsekutiver Frühgeburt und kindlicher High-Output-Herzinsuffizienz führte. Aus einer Literaturrecherche leiten wir zudem Hinweise zur Diagnostik und Empfehlungen zur optimalen Schwangerschaftsbetreuung bei Verdacht auf Chorioangiom ab.
In Vivo Assessment of Zinc Deficiency on Craniofacial Growth in a Rat Model
Authors: Kara Cankat , Orbak Recep , Dagsuyu Ilhan Metin , Orbak Zerrin , Bilici Necmettin , Gumustekin Kenan
Published: September 2019

Objectives: The aim of this study was to investigate the effects of low levels of zinc intake on the rat mandible and maxilla during growth and to compare these results with those of zinc-containing
rats.

Methods: The study was carried out on 14 Sprague-Dawley rats. The rats were randomly divided
into two groups. Group I rats were fed with a Zn-deficient diet, and Group II rats with a Zn-containing diet. At the end of the fourth week on the experimental diet, all the rats were killed and blood samples were taken. Serum Zn levels were measured by atomic absorption spectrophotometry. Then, the s ulls and mandibles were freed from soft tissues and measurements were made on the dry skulls, the mandibles, and teeth in both of the two groups.

Results: The zinc-deficient group showed a significantly lower value in dry skull, mandible, and teeth measurements when compared with those of the Group II.

Conclusions: Changes in zinc intake might exert an effect on the growth of craniofacial structures. A low-zinc diet during adolescence might slow bone and teeth growth and enhance the risk of oral, periodontal, and orthodontic problems in later years. (Eur J Dent 2009;3:10-15)
Adhesion to Primary and Permanent Dentin and a Simple Model Approach
Authors: Can-Karabulut Deniz C. , Oz Firdevs Tulga , Karabulut Baris , Batmaz Inci , Ilk Ozlem
Published: September 2019

Objectives: First to compare different dentin bonding agents’ shear bond strength to primary and permanent dentin. Secondly to compare the fracture failure modes and making an attempt to develop a statistical model that could be helpful in predicting them.

Methods: Extracted human primary and permanent molars were used as substrates (dentin). The shear bond strength of composite to substrate was measured and fracture surfaces were evaluated visually and with stereomicroscope. Using the data obtained, a statistical model was built in order to predict the failure modes.

Results: Higher bond strength values were obtained for permanent dentin. Total-etch adhesives displayed higher shear bond strength values than the self-etch adhesive. Adhesive failures were more frequently seen in primary dentin. Self-etch adhesive system displayed more adhesive failures. Prepared model confirmed the negative relationship between shear bond strength and the probability of observing adhesive failure.

Conclusions: There should be an application protocol for the usage of dentin bonding agents in primary dentin. Further development of statistical and fuzzy models for failure modes can be supportive alternatives for microscopic evaluations and also be helpful in understanding and eliminating the factors which are responsible for the formation of adhesive failures and for achieving clinically more successful adhesive restorations. (Eur J Dent 2009;3:32-41)
Caries is Associated with Asthma and Epilepsy
Authors: Anjomshoaa Ida , Cooper Margaret E. , Vieira Alexandre R.
Published: September 2019

Objectives: There is evidence of association between systemic diseases and oral conditions, although it is not clear if these are direct or mediated by underlying factors such as health behaviors. The aim of this work was to evaluate whether self-reported systemic diseases were associated with caries experience.

Methods: Medical history data and caries experience (DMFT and DMFS; Decayed, Missing due to caries, Filled Teeth/Surface) were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. Information on 318 subjects (175 females and 143 males) was evaluated. Regression analysis was used to test for association between caries experience and disease status.

Results: The stronger associations were found between caries experience and asthma and epilepsy. With respect to asthma, DMFT above 15 (R2 = 0.04) and DMFS above 50 (R2 = 0.02) were associated. After controlling for gender differences in asthma, the associations remained strong (R2 = 0.05 for both DMFT and DMFS). For epilepsy, DMFT above 15 (R2 = 0.18) and DMFS above 50 (R2 = 0.14) were associated.

Conclusions: Asthma and epilepsy are associated with higher caries experience. (Eur J Dent 2009;3:297-303)
Electron Microprobe Analysis in Guided Tissue Regeneration: A Case Report
Authors: González-Jaranay Maximino , Sánchez-Quevedo María del Carmen , Moreu Gerardo , García José Manuel , Campos Antonio
Published: September 2019

Objectives: Several procedures have been advocated as regenerative procedures in periodontology, but one of the most widely used techniques up to now is guided tissue regeneration (GTR). Likewise, different assessment methods based on clinical, radiographic or histological measurements have been proposed for the evaluation of these regenerative procedures. However, none of the methods used for human material incorporates quantitative X-ray microanalysis to assess the degree of mineralization of the regenerated periodontal hard tissues. The objective of this report was to evaluate, using quantitative X-ray microprobe analysis, the newly-formed hard tissue in a periodontal infrabony defect.

Methods: Electron microprobe analysis was used to study the nature of the newly-formed hard tissue 3 years after treatment with guided tissue regeneration in a patient with localized aggressive periodontitis.

Results: Our quantitative analyses, using the peak-to-background method, showed calcium/phosphorus mass ratio of 1.50±0.38 in the newly-formed hard tissue around the affected tooth root.

Conclusion: Quantitative X-ray microprobe analysis is a useful tool that may provide an accurate assessment of the degree of mineralization in an extremely small tissue sample. (Eur J Dent 2007;1:40- 44)
Use of FT-Raman Spectroscopy to Determine the Degree of Polymerization of Dental Composite Resin Cured with a New Light Source
Authors: Khalil Safaa K.H , Allam Mousa A , Tawfik Wael A
Published: September 2019

Objectives: To use the FT-Raman spectroscopy for evaluation the degree of polymerization of dental composite as a result of photo curing with a new light source in comparison to the conventional halogen light.

Materials and Methods: In this study a new light source, based on a metal-halide lamp (TOPSPOT G12) was developed at NRC-Egypt for curing dental composites. Two groups of 108 composite samples each were cured using both the new light source and a conventional halogen source, as a control source. Different samples’ sizes (2x2, 3x3 and 6x3 mm2) were cured for different periods of time (2, 4, 8, 12, 20, and 40 seconds). The spectroscopic data were analyzed statistically by ANOVA and Duncan’s multiple range test (P< .05).

Results: The results showed that the samples cured by the new metal-halide source produced higher polymerization rates than those cured by the halogen source. The polymerization rate was directly proportional to the exposure time and inversely proportional to the sample size, irrespective to the light source used. The results also showed that 12 seconds of metal-halide light curing produced polymerization rate comparable to or even higher than that produced by 40 seconds halogen light curing.

Conclusions: The new light source produced a satisfactory degree of polymerization in a remarkable shorter curing time and it can be recommended for clinical use. (Eur J Dent 2007;2:72-79)