bluuebunny/crossref_metadata_2025 huggingface dataset:
LE TRE FIERE DI DANTE IN PASOLINI: DALLA DIVINA COMMEDIA ALLA DIVINA MIMESIS
Authors: Coriasso Martín-Posadillo Cristina
Published: May 2022

During the ideological crisis of the 1950s, through the studies of Gianfranco Contini and Antonio Gramsci, the Divine Comedy proposed itself as an authorial, existential and political model and as a multilingual model, to which Auerbach's concept of Mimesis was added from 1957. A concept already prophetically sensitive to the arrival of neo-capitalism in the 1960s, which coincided, not by chance, with the triumph of the neo-avant-garde and the Gruppo 63. An artistic witness to the agonizing struggle against this arrival is La Divina Mimesis, an unfinished remake of Dante's poem, in which Pier Paolo Pasolini depicts the crisis of his mimetic poetics in the encounter between his 1950s self and his 1960s self. The characterization of the three beasts constitutes a sociolinguistic framework in which the author-actor does not renounce allegorical dialectics, identifying, in each one of them (lion-illusion, lion-superbia, she-wolf-conformism), the evil he recognizes in himself and in reality.

La Divina Commedia si propone, durante la crisi ideologica degli anni ’50, tramite gli studi di Gianfranco Contini e di Antonio Gramsci, come modello autoriale, esistenziale e politico e come modello plurilinguistico, ai quali si unisce, a partire dal 1957, il concetto di Mimesi di Auerbach, già profeticamente sensibile all’avvento del neocapitalismo degli anni ’60, coincidente in modo non casuale con il trionfo della neoavanguardia e del Gruppo 63. Testimone artistico dell’agonica lotta contro tale avvento è La Divina Mimesis, incompiuto rifacimento del poema dantesco, in cui Pier Paolo Pasolini raffigura la crisi della sua poetica mimetica nell’incontro fra il suo io degli anni ’50 e quello degli anni ’60. La caratterizzazione delle tre fiere costituisce un quadro sociolinguistico in cui l’autore-attore non rinuncia alla dialettica allegorica, individuando, in ognuna di esse (lonza-illusione, leone-superbia, lupa-conformismo), i mali che riconosce in sé e nella realtà.

La Divina Commedia si propone, durante la crisi ideologica degli anni ’50, tramite gli studi di Gianfranco Contini e di Antonio Gramsci, come modello autoriale, esistenziale e politico e come modello plurilinguistico, ai quali si unisce, a partire dal 1957, il concetto di Mimesi di Auerbach, già profeticamente sensibile all’avvento del neocapitalismo degli anni ’60, coincidente in modo non casuale con il trionfo della neoavanguardia e del Gruppo 63. Testimone artistico dell’agonica lotta contro tale avvento è La Divina Mimesis, incompiuto rifacimento del poema dantesco, in cui Pier Paolo Pasolini raffigura la crisi della sua poetica mimetica nell’incontro fra il suo io degli anni ’50 e quello degli anni ’60. La caratterizzazione delle tre fiere costituisce un quadro sociolinguistico in cui l’autore-attore non rinuncia alla dialettica allegorica, individuando, in ognuna di esse (lonza-illusione, leone-superbia, lupa-conformismo), i mali che riconosce in sé e nella realtà.
Had, humor og bystander-reaktioner: danske unges reaktioner på politisk hadefulde memes
Authors: Lindekilde Lasse , Rasmussen Jesper
Published: May 2022

En udfordring med hadefuldt indhold på sociale medier er, at det ofte er pakket ind i en tilsyneladende uskyldig humor. Det gør det hadefulde materiale sværere at genkende og afkode. De fleste kan genkende hadefuld propaganda, når det følges af et hagekors eller et IS-flag. Men hvordan ser det ud, når det hadefulde budskab er præsenteret som et humoristisk meme? Samtidig rejser eksponering for hadefuldt materiale på sociale medier et vigtigt spørgsmål om, hvordan vi som bystanders reagerer. Hvornår intervenerer bystanders prosocialt og for eksempel anmelder hadefuldt indhold, og hvornår reagerer de antisocialt og deler og liker sådant indhold? Artiklen bidrager med en første kortlægning af danske unges vurdering af hadefulde memes, og hvordan disse vurderinger medformer de unges bystander-reaktioner i forhold til deres villighed til at like, dele og anmelde indholdet. Desuden undersøges det, hvad der kendetegner dem, som er tilbøjelige til at reagere henholdsvis prosocialt og antisocialt på hadefulde budskaber på sociale medier med hensyn til køn, politisk interesse samt aktivistiske og politisk voldelige intentioner. Artiklen trækker på en elektronisk spørgeskemaundersøgelse blandt 814 danske folkeskole- og gymnasieelever i alderen 13 til 18 år.
Sobre el estatuto de la vida en el paradigma biopolítico foucaultiano
Authors: Raffin Marcelo Sergio
Published: May 2022

Este artículo analiza la noción de vida del paradigma biopolítico foucaultiano a partir de una bivalencia fundamental de la vida, entendida tanto como correlato de un poder que la domina y la administra, como posibilidad de un poder que resiste y que escapa siempre también a las tecnologías biopolíticas y se enfrenta a ellas. Ahora bien, ¿de dónde extrae Foucault esas virtualidades de la vida?, ¿con qué materiales construye ese concepto? y sobre todo, ¿qué alcances y potencialidades tiene? El análisis, que toma en consideración la producción foucaultiana en su conjunto así como el aparato crítico sobre esta problemática, destaca y se centra, en particular, en el ascendente nietzscheano, lo que tendrá consecuencias de importancia para comprender desarrollos ulteriores sobre la vida en el pensamiento del filósofo francés, como la estética de la existencia, la resistencia, la crítica y la libertad. Con el fin de llevar a cabo este trabajo, el artículo se estructura a partir de los siguientes puntos: una breve revisión de la noción de vida al interior de la producción foucaultiana en su conjunto; el análisis de la noción de vida que Foucault presenta hacia mediados de los años 1970 en lo que se podría denominar el “paradigma biopolítico” y, en particular, en su relación con las nociones de poder y de gobierno; el examen de la genealogía entre las nociones de vida y de poder del paradigma biopolítico foucaultiano y la noción nietzscheana de “voluntad de poder”; y la propuesta de un conjunto de conclusiones tentativas de la noción de vida en el paradigma biopolítico foucaultiano, destacando una serie de alcances y potencialidades del componente de la resistencia de esa noción.
Foucault, Esposito y las posibilidades de una biopolítica afirmativa: supuestos, tensiones e implicancias
Authors: Botticelli Sebastián
Published: May 2022

Dentro del amplio campo problemático que configuran las diversas indagaciones en torno a la biopolítica, se destacan aquéllas que estipulan la necesidad de ampliar, profundizar, completar e incluso enmendar las significaciones que Michel Foucault le imprimiera a este concepto durante la década de 1970. El presente artículo tomará en consideración la “biopolítica afirmativa” desarrollada por Roberto Esposito, la cual aparece caracterizada como el pasaje desde una política sobre la vida hacia una política de la vida. A partir del establecimiento de algunas tensiones entre los lineamientos generales del pensamiento foucaultiano y la biopolítica de Esposito, se buscará explicitar los supuestos de esta última y ponderar algunas de sus implicancias.
Entrevista com o Filósofo Timothy Morton
Authors: Pinho Thiago
Published: May 2022

Hoje tenho o prazer de receber aqui o filósofo Timothy Morton. Timothy Morton é professor na Rice University em Houston, EUA.  Ele escreveu mais de quinze livros, como por exemplo: "Hyperobjects: philosophy and ecology after the end of the world”, “Dark ecology”, “Being ecological”, “Ecology without nature”  e muitos outros ótimos livros. Ele escreveu mais de 200 ensaios sobre filosofia, ecologia, literatura, música, arte, arquitetura, design e alimentação. Além disso, a obra de Morton foi traduzida em 10 idiomas. Hoje vamos discutir muitas coisas, especialmente a interessante relação entre a Filosofia e a Ecologia. Professor Morton, muito obrigado por aceitar meu convite.
Manejos interventivos no auxílio ao tratamento não medicamentoso para Doença de Alzheimer: Revisão de Literatura
Authors: Granzotto Jonas Stradiotto , Carlesso Janaína Pereira Pretto
Published: May 2022

O presente artigo objetiva apresentar intervenções multidisciplinares no tratamento não medicamentoso para a Doença de Alzheimer (DA) através de uma revisão de literatura de abordagem qualitativa. O Alzheimer é uma doença crônica e de progressão constante em pessoas acima dos 60 anos, acometendo a pessoa idosa com Sintomas psiquiátricos, alterações na cognição e comprometendo a autonomia para realização de atividades de vida diária. Tendo em vista o crescimento da população idosa e respectivamente a maior incidência de doenças neurodegenerativas atreladas a este estágio de vida, torna-se primordial elencar as práticas interventivas desenvolvidas para o tratamento de idosos com comprometimento cognitivo e diagnóstico para a Doença de Alzheimer. Nesse estudo são apresentadas as técnicas de terapia de reminiscência (TR) e Mindfulness, demonstrando a aplicação e eficácia das terapias na modalidade de prevenção ou na atuação com grupos de pacientes já diagnosticados com a patologia. Os resultados encontrados pela aplicação de testes e escalas referem que ambos instrumentos de intervenção possibilitam melhoras na qualidade de vida, na realização de atividades do cotidiano, benefícios nos índices de depressão autorreferenciados e a nível neuronal com atenuação do nível de estresse. Conclui-se que estas são práticas indicadas para serem realizadas tanto em ambientes institucionais como fora destes contextos, e servem como parâmetro para a atuação do profissional psicólogo e outras áreas da Saúde.
“Melhor fase da vida”? – avaliação do bem-estar subjetivo de estudantes universitários
Authors: Silva Matheus Valim , Toni Caroline Guisantes De Salvo
Published: May 2022

O meio universitário tem sido um contexto emergente de estudos. Entre as temáticas estudadas está o sofrimento e adoecimento no meio universitário. Entretanto, o entendimento desse adoecimento enquanto uma problemática ainda carece de estudo e por isso tem despertado o interesse de pesquisadores e da área da saúde.  Assim, esta pesquisa busca levantar dados a respeito dos níveis de bem-estar subjetivo (BES) de estudantes em contexto acadêmico utilizando escalas e o referencial teórico ligado à Psicologia Positiva. A amostra da pesquisa contou com um total de 263 participantes, sendo 197 mulheres e 66 homens, tendo a média de idade de 21 anos, de cinco cursos diferentes de uma universidade publica. Para avaliação dos BES utilizou-se a Escala de Satisfação com a Vida (ESV) e a Positive and Negative Affect Schedule (PANAS).  Os resultados apontaram para um baixo BES generalizado da amostra, com um aumento significativo do valor de Afetos Negativos ao longo do processo de graduação. Ainda, a variável gênero feminino mostrou-se relacionada a baixo nível de afetos positivos e alto nível de afetos negativos, quando comparada a varável gênero masculino. Conclui-se que a universidade parece ser uma variável que contribui para uma piora dos níveis de BES dos indivíduos.
Famílias no pós-divórcio: envolvimento paterno e guarda dos(as) filhos(as) na perspectiva de pais e mães divorciados
Authors: Roos Campeol Ângela , Abreu Pereira Oliveira Joyce Lúcia , Crepaldi Maria Aparecida
Published: May 2022

Os (re)arranjos familiares são necessários no contexto pós-divórcio, a fim de preservar os vínculos entre pai, mãe e filhos(as). Este estudo de abordagem qualitativa e enfoque empírico teve por objetivo caracterizar o envolvimento do pai com os filhos(as) após o término da conjugalidade de acordo com a modalidade de guarda, na perspectiva de pais e mães divorciados(as). Participaram 12 pessoas divorciadas, em dois grupos focais, sendo um composto com seis mulheres/mães e o outro com seis homens/pais, com crianças pequenas. Os dados foram analisados através da análise categorial temática, utilizando-se do software Atlas.ti 5.0 para organização dos dados. Os resultados foram organizados em três categorias temáticas:  envolvimento paterno: os desdobramentos de pais com guarda compartilhada;  o envolvimento paterno de pais “visitantes”: as implicações da guarda unilateral materna e; percepções sobre modalidades de convivência e pensão alimentícia. Este estudo pretende contribuir com o avanço das pesquisas sobre o envolvimento paterno no contexto do divórcio e demarca a importância da guarda compartilhada, como um fator de proteção para o engajamento do pai com os(as) filhos(as), devendo ser incentivada sempre que for possível. Considerando que a guarda compartilhada pode ser determinada em juízo, mesmo nos casos em que há conflitos entre os ex-cônjuges, revela-se a importância do apoio psicológico à pais e mães no período de transição para o divórcio, visando ajudá-los a lidar com aspectos emocionais e relacionais.Palavras-chave: relações pai-filhos; divórcio; envolvimento paterno; guarda compartilhada; paternidade.
Mães de Anjos: A experiência de mulheres que tiveram um filho natimorto
Authors: Bonani Isadora Ribeiro , Cordeiro Silvia Nogueira , De Campos Karina Stagliano
Published: May 2022

A gestação e a maternidade são marcadas por intensas vivências e múltiplas exigências; é um período de reorganização corporal, familiar, social e psíquica. Por esses fatores, a perda gestacional se torna um fenômeno bastante complexo, pois há um abrupto rompimento das transformações gestacionais e a perda do bebê implica a vivência do luto. O óbito fetal é caracterizado pela morte do feto antes da expulsão completa do corpo da mãe a partir da 22° semana de gestação. O presente estudo teve o objetivo de identificar aspectos psíquicos de mulheres que passaram pela experiência da perda por óbito fetal e analisar o processo de luto. Trata-se de uma pesquisa clínico-qualitativa descritiva. Para a coleta dos dados utilizou-se amostragem proposital e/ou intencional por “bola de neve” e entrevista semidirigida. A técnica utilizada para análise das entrevistas foi a análise de conteúdo. Os resultados apontaram três categorias: É algo que vem pra ti e ponto, A perda fetal e os laços sociais e Mães de anjos. Foi demonstrado como o tabu sobre o óbito fetal pode prejudicar o luto e reforçar preconceitos com mulheres que viveram essa experiência. A forma que as entrevistadas encontraram de se sentirem acolhidas foram grupos de apoio, nos quais puderam se nomear como“mães de anjos”.
Status atual do tratamento em uma sessão para fobias específicas
Authors: D'EL REY GUSTAVO J. FONSECA , BARTHOLOMEU DANIEL , MONTIEL JOSÉ MARIA
Published: May 2022

O tratamento em uma sessão (OST) é uma forma de exposição intensa para o tratamento das fobias especificas. O OST combina técnicas de exposição ao vivo, reestruturação cognitiva, modelagem participativa e reforço positivo em uma única sessão de 03 horas. O presente trabalho teve como objetivo analisar os artigos indexados nas bases de dados Medline e Psycinfo no período entre 2009 e 2020, identificando estudos sobre a eficácia do OST nas fobias especificas. A amostra final foi constituída por 13 artigos. Todos os artigos atestaram a eficácia positiva dessa forma de tratamento nos diversos estímulos fóbicos tratados. Uma maior divulgação do OST deve ser incentivada no Brasil, para que as pessoas acometidas por esse transtorno de ansiedade possam se beneficiar dos efeitos muito bem estabelecidos dessa forma de tratamento.
Relações entre tecnologias de informação e comunicação e interações familiares: revisão sistemática da literatura
Authors: Garzella Gabriela Beatris , Enricone Jacqueline Raquel Bianchi , Perin Isabella Lise , De Souza Luiz Henrique , Neumann Angélica Paula
Published: May 2022

As tecnologias de informação e comunicação (TIC’s) fazem parte do cotidiano de indivíduos de todas as faixas etárias e em diferentes contextos, interatuando também com as relações familiares. Diante disso, realizou-se uma revisão sistemática de literatura com o objetivo de compreender as relações entre o uso das TIC’s por crianças de 10 a 12 anos e as interações familiares. O levantamento dos artigos foi realizado nas bases de dados EBSCO, PsycINFO e BVSPsi. Após os procedimentos de seleção, 12 artigos compuseram o corpus de análise. Os resultados foram organizados em três categorias temáticas: Padrões de uso das TIC’s; Preocupações dos pais acerca do uso das TICs pelas crianças e estratégias de regulação parental; e Relações entre o uso das TIC’s e as interações familiares. Verificou-se fácil acesso aos dispositivos digitais e alta frequência de uso pelas crianças. Os pais demonstraram preocupações sobre os riscos que seus filhos correm ao utilizar as tecnologias, mas, ao mesmo tempo, apresentaram dificuldades acerca de como monitorar esse uso. As estratégias de controle parentais eram diversificadas, e os estudos investigaram mais o controle do tempo de uso do que dos conteúdos acessados. O uso das TICs pelas crianças pode impactar positiva ou negativamente nas interações familiares. Recursivamente, a dinâmica relacional da família influencia na forma deste uso. Percebe-se necessidade de aprofundar estes conhecimentos por meio de novos estudos e de compreender as relações circulares e as retroalimentações entre todos os elementos identificados.
FELICIDADE NO TRABALHO NO BRASIL: UMA REVISÃO SISTEMÁTICA DA LITERATURA.
Authors: Ferreira Poliana Gonçalves
Published: May 2022

A Felicidade é importante no contexto do trabalho porque propicia bem-estar físico e psicossocial. Este artigo tem como propósito apresentar os resultados encontrados numa revisão de literatura sobre Felicidade no trabalho nos últimos cinco anos. Foram realizadas buscas nas bases de dados BVS, Scielo e Pepsi acessadas por meio do Portal de Periódicos da Capes a partir dos descritores: “Felicidade no trabalho” e “Felicidade” e “trabalho”, totalizando nove artigos. Além dos dados bibliométricos foram analisados o delineamento de pesquisa, participantes, instrumentos, resultados e conclusão, como também o conceito de Felicidade no trabalho utilizado. Ao propor uma perspectiva que procura integrar e convergir o conhecimento existente, o presente artigo oferece um quadro de análise para o desenvolvimento futuro deste tema. Esse aspecto, no entanto, possibilita o emprego de perspectivas mais abrangentes em novos estudos, podendo também facilitar a identificação de lacunas da literatura e novos caminhos de pesquisa.
Experiências laborais de catadores de materiais recicláveis de uma associação
Authors: Braga Natalia Lopes , Maciel Regina Heloisa , Lima Ana Cláudia Freire Barreto
Published: May 2022

Em função do aumento dos resíduos sólidos urbanos e de contextos de desemprego, ganha corpo o número de catadores de materiais recicláveis na atualidade. Os catadores de materiais recicláveis representam uma ampla categorial laboral muitas vezes marginalizada, atravessada por preconceitos e estigmas, que carece de visibilidade e atenção de políticas públicas. A pesquisa objetivou compreender as trajetórias e experiências laborais de catadores de materiais recicláveis de uma associação. Foram entrevistados seis catadores de uma associação e os dados foram analisados através da análise de conteúdo. Os resultados mostraram que os catadores apresentam um discurso de satisfação com o trabalho que se contrapõe ao desejo de estar no mercado de trabalho formal e de ter a carteira assinada. Alguns problemas dificultam a organização da associação, como a falta de comprometimento e rotatividade dos membros. Pode-se concluir que a catação entra na vida dos sujeitos com vistas a atender uma necessidade imediata, qual seja a obtenção de renda para seu sustento, mas acaba se consolidando na vida dos sujeitos.
O cuidar e seus impactos negativos para cuidador familiar de pessoa com Alzheimer
Authors: Monteiro Marcelo Roberto , Pedroza Bruna Salmazo , Guimarães Claudiane Aparecida
Published: May 2022

O presente estudo objetivou investigar os impactos que o cuidado a um indivíduo com Alzheimer pode gerar ao cuidador, assim como, possíveis alternativas desenvolvidas por este, para lidar com as adversidades. Realizou-se uma revisão sistemática nas bases de dados BVS Saúde e SciELO, com os descritores ‘Cuidado’, ‘Cuidador’, ‘Alzheimer’. Selecionou-se estudos disponíveis na íntegra, acesso gratuito, dentre os anos de 2015 a 2020, escritos em português, inglês e espanhol. Os resultados encontrados apontam para a existência de ônus físico, psicológico, social e financeiro ao cuidador. O perfil comum do cuidador é de mulheres, filhas ou esposas do enfermo, que assistem ao doente de forma solitária, ou com pouco amparo, são voluntárias e dedicam parcela significativa de suas rotinas à assistência.
Chronic scrotal erythredema revealing lupus in a sixteen-year-old male
Authors: Elmansouri Meriem , Elfatoiki Fatima-Zohra , Hali Fouzia , Chiheb Soumiya
Published: May 2022

The literature insufficiently describes the etiologies of chronic penoscrotal edema, and even more so those of chronic permanent scrotal erythredema. Herein, we report the case of a sixteen-year-old male who presented, in addition to permanent and chronic scrotal erythredema, classical cutaneous manifestations of systemic lupus. The patient had received systemic corticosteroid therapy combined with hydroxychloroquine. The evolution was good, without new outbreaks or recurrences of penoscrotal edema. Apart from the usual urological emergencies, systemic diseases may be involved in scrotal erythredema, which requires long-term medical management.
Hidradenitis suppurativa and bilateral interstitial keratitis: A case report
Authors: Robinson India , Santa Lucia Gabriella , Ritter Alex , Plante John , Valdebran Manuel
Published: May 2022

Hidradenitis Suppurativa (HS) is a chronic inflammatory disease that cause painful abscess and nodules in skin that contain apocrine glands. While HS has known associations with several inflammatory disorders, a rare association is interstitial keratitis. We present a case of bilateral interstitial keratitis attributed to a severe flare of HS disease resulting in systemic inflammation. Other case reports have established that bilateral interstitial keratitis can be attributed to HS, as well as other eye symptoms and diseases. Despite the rarity of keratitis in patients with HS, clinicians should be aware that this association does exist when their HS patient presents with severe or atypical eye symptoms.
Becker’s nevus syndrome: A new case series
Authors: Brzeziński Piotr , Chiriac Anca , Bimbi César , Martini Lorenzo , Borowska Katarzyna
Published: May 2022

Becker’s nevus syndrome (BNS) is a rare epidermal nevus syndrome characterized by Becker’s nevi and other, often unobtrusive, systemic symptoms and/or skin lesions, often ipsilateral. A Becker’s nevus (BN) is a hamartoma that is unilateral, hyperpigmented, and often hairy. Systemic symptoms typically involve breast gland hypoplasia and skeletal and muscular disorders. Herein, we describe three rare cases of Becker’s nevus syndrome. In the first case, the BN coexisted with ipsilateral breast gland hypoplasia; in the second case, the BN coexisted on both sides with breast gland hypoplasia and keratosis pilaris only in the left antecubital region and with scoliosis; in the third case, we found two Becker’s nevi in the left and right hip area associated with hypoplasia of the third canine tooth on the right side and with scoliosis. Our three cases were sporadic and all occurred in males. Coexisting symptoms of BN were found accidentally. We describe two new coexisting symptoms: atypical keratosis pilaris and hypoplasia of the canine teeth.
Cutaneous lupus: Immunofluorescence and lupus band test
Authors: Ramírez-Marín Hassiel Aurelio , Aleisa Ahmad , Lima-Galindo Anabell Andrea , Mendez-Flores Silvia
Published: May 2022

Cutaneous lupus erythematosus is an autoimmune disease with a broad range of clinical findings. There are several methods to conduct a diagnostic approach, among these stands direct immunofluorescence, in which we can find the Lupus Band Test (LBT) consisting of a band of granular deposits of immunoglobulins and complement along the dermo-epidermal junction. It can have a high sensitivity and specificity for diagnosis in some cases, according to the biopsy site, the constituents of immunorreactants found at the dermoepidermal junction, and the morphology and intensity of the immunofluorescent band. Certain limitations of the test should be considered when interpreting the results. Although useful in diagnosis, the lupus band is not considered a pathognomonic sign of erythematous lupus. About one-third of patients with positive direct immunofluorescence on a skin biopsy do not have systemic lupus erythematosus (SLE). A positive LBT in non-lesional photoprotected skin represents a criterion with high specificity to identify patients with SLE.
Symmetric periorbital edema after mRNA COVID-19 vaccine
Authors: Belyova Veselina , Darlenski Razvigor
Published: May 2022

A 42-year-old Caucasian female patient presented with symmetric, asymptomatic, periorbital angioedema (Fig. 1) that appeared 24 hours after the second dose of the Moderna mRNA COVID-19 vaccine. She was injected with the hyaluronic acid dermal filler Juvéderm Volite in the glabella and periorbital area three months earlier and underwent a botulinum toxin session in the forehead, glabella, and crow’s feet with Vistabel six months earlier. No present or previous history of allergy or concomitant diseases was reported. Cetirizine dihydrochloride 3 × 10 mg and cold compresses resulted in the complete resolution of the symptoms within three days. Reactions to the Moderna vaccine possibly related to the dermal filler placement are rare and have an unknown pathogenesis. Three out of 15,184 patients developed facial or lip swelling after mRNA vaccine [1]. These reactions may be immunologically triggered by viral or bacterial illness and vaccinations, including allergies to vaccine ingredients such as polyethylene glycol.
Warty papules on the hands and feet: Acrokeratosis verruciformis of Hopf
Authors: Frioui Refka , Tabka Mariem , Mokni Sana , Ghanem Azza , Fetoui Nedia , Ounallah Amina , Belajouza Colandane , Denguezli Mohamed
Published: May 2022

A 47-year-old female was referred to our department because of skin-colored lesions located mainly on the dorsum of the hands and feet. The patient had no diseases and had not taken continuous medication. The lesions were present at birth and had increased in number since then. Four more members of the family, including the mother and the uncle (mother’s brother), had similar skin lesions. A dermatological examination revealed multiple flesh-colored, flat-topped papules, about 2–5 mm in size, which were reminiscent of flat warts on the dorsum of the hands and feet (Fig. 1). A nail examination revealed thickened nails with V-shaped nicks at their free margins on the fingers of both hands (Fig. 2). The patient declined skin biopsy. We retained the diagnosis of acrokeratosis verruciformis of Hopf (AVH). AVH is a rare inherited disorder of keratinization caused by an abnormal ATP2A2 gene [1,2]. Familial cases indicate an autosomal dominant pattern of inheritance, yet sporadic cases of the disease have also been reported [2]. It is characterized by multiple asymptomatic, flat-topped, skin-colored papules on the dorsum of the hands and feet. Other features may include pits on the palms and soles and nail dystrophy (pearly white nails or nails with longitudinal ridges and nicks in the free edge) [3]. AVH is diagnosed clinically, which becomes easier if there are family members with similar skin findings. Sometimes, a skin biopsy is performed to assist the diagnosis. The key features on histology are hyperkeratosis, hypergranulosis, acanthosis, papillomatosis, and circumscribed epidermal elevations known as church spires, which are a distinctive finding [1,2].
The role of patch and photopatch tests in facial melanoses: A cross-sectional, observational study
Authors: Sachdeep Kaur , Tejinder Kaur , Suresh Malhotra
Published: May 2022

Background: Facial pigmentation includes various entities such as melasma, lichen planus pigmentosus (LPP), and pigmented contact dermatitis. The pathogenesis may involve certain allergens, which may be responsible for causing a disturbance in the dermoepidermal junction. The elimination of such inciting allergens may aid in the successful treatment of these patients. Objective: The aim was to detect contact allergens with patch and photopatch testing in facial pigmentary disorders. Methods: Fifty patients with facial pigmentary disorders were enrolled. After taking a demographic profile and detailed clinical history and performing an examination, patch and photopatch testing was done using a common suspected allergen series. Results: Out of the fifty patients tested, 28 (56%) showed a positive patch test, while 2 (4%) showed a positive photopatch test. The most common allergen found was a fragrance mix in 17 (34%) patients, followed by paraphenylenediamine (PPD) in 11 (22%). Other allergens showing positivity were nickel sulfate, benzocaine, parthenium, benzophenone-3, octyl methoxycinnamate, etc. Conclusion: Patients with facial pigmentation may have an underlying component of contact dermatitis, which may be a causative or aggravating factor. The avoidance of these allergens may help in increasing the efficacy of treatment in these patients.
Kawasaki-like disease in children with COVID-19
Authors: Kerrouch Hasna , Khalidi Meryem , Frikh Rachid , Hjira Naoufal , Boui Mohammed
Published: May 2022

Sir, In late 2019, a new type of viral infection emerged in Wuhan, China, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19) and which has become the most challenging pandemic of this century. COVID-19 has affected individuals of all ages worldwide. Epidemiological data from numerous countries show that children are a small minority of those who test positive. Most children with COVID-19 show mild symptoms or are asymptomatic, yet new concerns have emerged, with reports on hyperinflammatory states or Kawasaki-like disease [1,2]. Kawasaki disease (KD) is a systemic vasculitis of unknown etiology that occurs mainly in children and rarely in adults [3]. Herein, we report a child with Kawasaki-like disease associated with COVID-19. A fifteen-year-old boy presented to our department with a four-day history of high fever, vomiting, diarrhea, abdomen pain, and erythematous rash. His previous medical history was unremarkable. A physical examination revealed diffuse, erythematous, maculopapular rash, bilateral conjunctivitis, erosive hyperemia of the oral mucosa, scrotal erythema, and a deepithelialized tongue (Figs. 1 and 2).
PowerPoint presentations (PPP): From A to Z
Authors: Sharma Prateek , Ramesh V , Al Aboud Khalid
Published: May 2022

In the last several decades of the twentieth century, an overhead projector was a great option for giving presentations. One could write the main points on a transparent sheet and project it onto a screen, including drawings and graphs. Alternatively, slides incorporating such information could be projected on a screen with a carousel. The limitations included carrying these and the inability to share or make changes later. The 1990s heralded the era of PowerPoint presentations (PPPs), which have relegated these to history. Toward the end of the second millennium, when the digital mode took over numerous tasks, PPPs became the sine qua non in almost every form of activity. PPPs refer to presentations made with a PowerPoint slideshow projected from a computer. It allows for the systematic presentation of a clinical subject followed by structured feedback from the audience. PPPs carry numerous advantages as it is a condensation of the source material by which the reader may assimilate information in a short time and record it through screenshots and video recording.Some obstacles, however, may limit the delivery of an effective presentation, for instance: Lack of clarity; Not knowing the supervisor’s expectations [1]; Limited data outlining the established standards for effective presentations [2]. This article outlines key points constituting an effective PPP as an efficient mode of skills assessment to promote competency-based medical education.
A study on the association between thyroid dysfunction and various dermatoses in northeastern India
Authors: Thokchom Nandakishore , Verma Kapila , Hafi Bishurul NA , Kshetrimayum Sandhyarani , Hmar Vanlalhriatpuii , Kongbam Linda , Bhattacharjee Nandita
Published: May 2022

Background: Thyroid abnormalities are a well-documented endocrine association seen in numerous dermatological conditions. However, there are few Indian studies analyzing the thyroid status in various dermatoses. Materials and Methods: This cross-sectional, observational study was conducted on 805 willing patients with various dermatoses, irrespective of the disease classification. Serum samples were taken and assayed for triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH). Results: Out of the 805 patients, 14.2% (n = 115) had abnormal thyroid function. Hypothyroidism accounted for 86.1% (n = 99) and hyperthyroidism for 13.9% (n = 16). Among the 99 hypothyroid patients, 23.2% (n = 23) had overt hypothyroidism while 76.8% (n = 76) had subclinical hypothyroidism. Vitiligo accounted for 36.1% (n = 291) of the patients, among which 12.3% (n = 36) had thyroid dysfunction involving six hypothyroid and three hyperthyroid cases. Out of 58 cases of melasma, 15 (25.8%) had abnormal thyroid function. Among the twenty patients with lichen planus pigmentosus, five had abnormal thyroid levels. Conclusion: This study demonstrates a strong association of thyroid disorders in certain conditions, such as vitiligo, alopecia areata, diffuse hair loss, dry skin, chronic urticaria, and melasma. Thus, the inclusion of thyroid function tests in routine investigations of these conditions would be helpful.
COVID-19 and pemphigus: A descriptive series of twelve cases
Authors: Mehsas Zoubida , Sektaoui Soukaina , Meziane Meriem , Ismaili Nadia , Benzekri Leila , Senouci Karima
Published: May 2022

Background: Patients with pemphigus receiving immunosuppressive therapy are considered at risk of developing severe forms of COVID-19. We aimed to analyze the clinical and evolutionary characteristics of COVID-19 infection in patients with pemphigus receiving general corticosteroid therapy by a retrospective descriptive study of twelve cases. Patients and Methods: We identified´ pemphigus cases that developed a COVID-19 infection. The data collected included the characteristics and treatment of pemphigus and the features and course of COVID-19 infection. Results: Twelve patients were followed at our department for pemphigus and a developed COVID-19 infection. Nine patients had a severe form of pemphigus, and three were in clinical remission. The infection was severe in three patients. The evolution was good in all patients. Discussion: Our study suggests that systemic corticosteroid therapy in patients with severe forms of pemphigus may be a protective factor against severe forms of SARS-CoV-2 infection. This theory should be evaluated by a larger study.
Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells
Authors: Ren Boyang , Xia Huan , Liao Yijun , Zhou Hang , Wang Zhongnan , Shi Yaoyao , Zhu Mingzhao
Published: May 2022

Thymic homing of hematopoietic progenitor cells (HPCs) is tightly regulated for proper T cell development. Previously we have identified a subset of specialized thymic portal endothelial cells (TPECs), which is important for thymic HPC homing. However, the underlying molecular mechanism still remains unknown. Here, we found that signal regulatory protein alpha (SIRPα) is preferentially expressed on TPECs. Disruption of CD47-SIRPα signaling in mice resulted in reduced number of thymic early T cell progenitors (ETPs), impaired thymic HPC homing, and altered early development of thymocytes. Mechanistically, Sirpa-deficient ECs and Cd47-deficient bone marrow progenitor cells or T lymphocytes demonstrated impaired transendothelial migration (TEM). Specifically, SIRPα intracellular ITIM motif-initiated downstream signaling in ECs was found to be required for TEM in an SHP2- and Src-dependent manner. Furthermore, CD47 signaling from migrating cells and SIRPα intracellular signaling were found to be required for VE-cadherin endocytosis in ECs. Thus, our study reveals a novel role of endothelial SIRPα signaling for thymic HPC homing for T cell development.
Functional and structural segregation of overlapping helices in HIV-1
Authors: Safari Maliheh , Jayaraman Bhargavi , Zommer Henni , Yang Shumin , Smith Cynthia , Fernandes Jason D , Frankel Alan D
Published: May 2022

Overlapping coding regions balance selective forces between multiple genes. One possible division of nucleotide sequence is that the predominant selective force on a particular nucleotide can be attributed to just one gene. While this arrangement has been observed in regions in which one gene is structured and the other is disordered, we sought to explore how overlapping genes balance constraints when both protein products are structured over the same sequence. We use a combination of sequence analysis, functional assays, and selection experiments to examine an overlapped region in HIV-1 that encodes helical regions in both Env and Rev. We find that functional segregation occurs even in this overlap, with each protein spacing its functional residues in a manner that allows a mutable non-binding face of one helix to encode important functional residues on a charged face in the other helix. Additionally, our experiments reveal novel and critical functional residues in Env and have implications for the therapeutic targeting of HIV-1.
Early detection of cerebrovascular pathology and protective antiviral immunity by MRI
Authors: Liu Li , Dodd Steve , Hunt Ryan D , Pothayee Nikorn , Atanasijevic Tatjana , Bouraoud Nadia , Maric Dragan , Moseman E Ashley , Gossa Selamawit , McGavern Dorian B , Koretsky Alan P
Published: May 2022

Central nervous system (CNS) infections are a major cause of human morbidity and mortality worldwide. Even patients that survive, CNS infections can have lasting neurological dysfunction resulting from immune and pathogen induced pathology. Developing approaches to noninvasively track pathology and immunity in the infected CNS is crucial for patient management and development of new therapeutics. Here, we develop novel MRI-based approaches to monitor virus-specific CD8+ T cells and their relationship to cerebrovascular pathology in the living brain. We studied a relevant murine model in which a neurotropic virus (vesicular stomatitis virus) was introduced intranasally and then entered the brain via olfactory sensory neurons – a route exploited by many pathogens in humans. Using T2*-weighted high-resolution MRI, we identified small cerebral microbleeds as an early form of pathology associated with viral entry into the brain. Mechanistically, these microbleeds occurred in the absence of peripheral immune cells and were associated with infection of vascular endothelial cells. We monitored the adaptive response to this infection by developing methods to iron label and track individual virus specific CD8+ T cells by MRI. Transferred antiviral T cells were detected in the brain within a day of infection and were able to reduce cerebral microbleeds. These data demonstrate the utility of MRI in detecting the earliest pathological events in the virally infected CNS as well as the therapeutic potential of antiviral T cells in mitigating this pathology.
Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse
Authors: Richardson Amy , Ciampani Victoria , Stancu Mihai , Bondarenko Kseniia , Newton Sherylanne , Steinert Joern R , Pilati Nadia , Graham Bruce P , Kopp-Scheinpflug Conny , Forsythe Ian D
Published: May 2022

Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited this to test for subunit-specific roles at the calyx of Held presynaptic terminal in the mouse. Deletion of Kv3.3 (but not Kv3.1) reduced presynaptic Kv3 channel immunolabelling, increased presynaptic AP duration and facilitated excitatory transmitter release; which in turn enhanced short-term depression during high-frequency transmission. The response to sound was delayed in the Kv3.3KO, with higher spontaneous and lower evoked firing, thereby reducing signal-to-noise ratio. Computational modelling showed that the enhanced EPSC and short-term depression in the Kv3.3KO reflected increased vesicle release probability and accelerated activity-dependent vesicle replenishment. We conclude that Kv3.3 mediates fast repolarisation for short precise APs, conserving transmission during sustained high-frequency activity at this glutamatergic excitatory synapse.
Text mining for identification of biological entities related to antibiotic resistant organisms
Authors: Fortunato Costa Kelle , Almeida Araújo Fabrício , Morais Jefferson , Lisboa Frances Carlos Renato , Ramos Rommel T. J.
Published: May 2022

Antimicrobial resistance is a significant public health problem worldwide. In recent years, the scientific community has been intensifying efforts to combat this problem; many experiments have been developed, and many articles are published in this area. However, the growing volume of biological literature increases the difficulty of the biocuration process due to the cost and time required. Modern text mining tools with the adoption of artificial intelligence technology are helpful to assist in the evolution of research. In this article, we propose a text mining model capable of identifying and ranking prioritizing scientific articles in the context of antimicrobial resistance. We retrieved scientific articles from the PubMed database, adopted machine learning techniques to generate the vector representation of the retrieved scientific articles, and identified their similarity with the context. As a result of this process, we obtained a dataset labeled “Relevant” and “Irrelevant” and used this dataset to implement one supervised learning algorithm to classify new records. The model’s overall performance reached 90% accuracy and the f-measure (harmonic mean between the metrics) reached 82% accuracy for positive class and 93% for negative class, showing quality in the identification of scientific articles relevant to the context. The dataset, scripts and models are available at https://github.com/engbiopct/TextMiningAMR.
How training loads in the preparation and competitive period affect the biochemical indicators of training stress in youth soccer players?
Authors: Andrzejewski Marcin , Konefał Marek , Podgórski Tomasz , Pluta Beata , Chmura Paweł , Chmura Jan , Marynowicz Jakub , Melka Kamil , Brazaitis Marius , Kryściak Jakub
Published: May 2022

Background

Physical fitness optimization and injury risk-reducing require extensive monitoring of training loads and athletes’ fatigue status. This study aimed to investigate the effect of a 6-month training program on the training-related stress indicators (creatine kinase – CK; cortisol – COR; serotonin – SER; brain-derived neurotrophic factor – BDNF) in youth soccer players.

Methods

Eighteen players (17.8 ± 0.9 years old, body height 181.6 ± 6.9 cm, training experience 9.7 ± 1.7 years) were blood-tested four times: at the start of the preparation period (T0), immediately following the preparation period (T1), mid-competitive period (T2), and at the end of the competitive period (T3). CK activity as well as concentrations of serum COR, SER and BDNF were determined. Training loads were recorded using a session rating of perceived exertion (sRPE).

Results

Statistical analyzes revealed significant effects for all biochemical parameters in relation to their time measurements (T0, T1, T2, T3). The statistical analyzes of sRPE and differences of biochemical parameters in their subsequent measurements (T0–T1, T1–T2, T2–T3) also demonstrated significant effects observed for all variables: sRPE (HKW = 13.189 (df = 2); p = 0.00), COR (HKW = 9.261 (df = 2); p = 0.01), CK (HKW = 12.492 (df = 2); p = 0.00), SER (HKW = 7.781 (df = 2); p = 0.02) and BDNF (HKW = 15.160 (df = 2); p < 0.001).

Discussion

In conclusion, it should be stated that the most demanding training loads applied in the preparation period (highest sRPE values) resulted in a significant increase in all analyzed biochemical training stress indicators. The reduction in the training loads during a competitive period and the addition of recovery training sessions resulted in a systematic decrease in the values of the measured biochemical indicators. The results of the study showed that both subjective and objective markers, including training loads, are useful in monitoring training stress in youth soccer players.
Build an Artificial Coral Reef Community Extension Project: An Impact Study
Authors: Ballesteros Jose
Published: May 2022

Coral reefs are ecologically important as they provide shelter and life support to the marine resources, sustain ecological balance, and human existence. Coral reef degradation is an ecological problem that needs human intervention and is considered a school’s social responsibility. The USANT College of Maritime Education and College of Engineering and Architecture rationalized social responsibility in partnership with the Bureau of Fisheries and Aquatic Resources (BFAR) and the Philippine Coast Guard Auxiliary (PCGA) and the barangay Pararao, Balatan, Camarines Sur, Region V, Philippines. The researcher used the Impact Evaluation and Study Design substantiated by an FGD and Underwater Diving of BFAR marine specialists to ascertain the impacts of the artificial coral reef project in drawing environmental awareness and determine the actual effect of the artificial coral reefs as shelters and spawning sites of fishes. Findings reveal that communal participation in safeguarding the vicinity of the reefs emanating at the barangay level is evident; the community folks had gained an understanding of the role of coral reefs in the ecosystem and school of fishes shoaled in the vicinity. Thus, this coral reef project drew positive attention, reduced minimalistic attitudes, and increased environmental awareness. The artificial reefs now serve as natural habitats. Active partnership and participation of the stakeholders and the provision of budget are imperative to sustainable project implementation.