bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Sensor Placement on Measured Distal Tibial Accelerations During Running
Authors: Sara Lauren K. , Outerleys Jereme , Johnson Caleb D.
Published: April 2023

Inertial measurement units (IMUs) attached to the distal tibia are a validated method of measuring lower-extremity impact accelerations, called tibial accelerations (TAs), in runners. However, no studies have investigated the effects of small errors in IMU placement, which would be expected in real-world, autonomous use of IMUs. The purpose of this study was to evaluate the effect of a small proximal shift in IMU location on mean TAs and relationships between TAs and ground reaction force loading rates. IMUs were strapped to 18 injury-free runners at a specified standard location (∼1 cm proximal to medial malleolus) and 2 cm proximal to the standard location. TAs and ground reaction forces were measured while participants ran at self-selected and 10% slower/faster speeds. Mean TA was lower at the standard versus proximal IMU location in the faster running condition (P = .026), but similar in the slower (P = .643) and self-selected conditions (P = .654). Mean TAs measured at the standard IMU explained more variation in ground reaction force loading rates (r2 = .79−.90; P < .001) compared with those measured at the proximal IMU (r2 = .65−.72; P < .001). These results suggest that careful attention should be given to IMU placement when measuring TAs during running.
Three-dimensional genome rewiring in loci with human accelerated regions
Authors: Keough Kathleen C. , Whalen Sean , Inoue Fumitaka , Przytycki Pawel F. , Fair Tyler , Deng Chengyu , Steyert Marilyn , Ryu Hane , Lindblad-Toh Kerstin , Karlsson Elinor ,   Zoonomia Consortium§, Nowakowski Tomasz , Ahituv Nadav , Pollen Alex , Pollard Katherine S. , Andrews Gregory , Armstrong Joel C. , Bianchi Matteo , Birren Bruce W. , Bredemeyer Kevin R. , Breit Ana M. , Christmas Matthew J. , Clawson Hiram , Damas Joana , Di Palma Federica , Diekhans Mark , Dong Michael X. , Eizirik Eduardo , Fan Kaili , Fanter Cornelia , Foley Nicole M. , Forsberg-Nilsson Karin , Garcia Carlos J. , Gatesy John , Gazal Steven , Genereux Diane P. , Goodman Linda , Grimshaw Jenna , Halsey Michaela K. , Harris Andrew J. , Hickey Glenn , Hiller Michael , Hindle Allyson G. , Hubley Robert M. , Hughes Graham M. , Johnson Jeremy , Juan David , Kaplow Irene M. , Karlsson Elinor K. , Keough Kathleen C. , Kirilenko Bogdan , Koepfli Klaus-Peter , Korstian Jennifer M. , Kowalczyk Amanda , Kozyrev Sergey V. , Lawler Alyssa J. , Lawless Colleen , Lehmann Thomas , Levesque Danielle L. , Lewin Harris A. , Li Xue , Lind Abigail , Lindblad-Toh Kerstin , Mackay-Smith Ava , Marinescu Voichita D. , Marques-Bonet Tomas , Mason Victor C. , Meadows Jennifer R. S. , Meyer Wynn K. , Moore Jill E. , Moreira Lucas R. , Moreno-Santillan Diana D. , Morrill Kathleen M. , Muntané Gerard , Murphy William J. , Navarro Arcadi , Nweeia Martin , Ortmann Sylvia , Osmanski Austin , Paten Benedict , Paulat Nicole S. , Pfenning Andreas R. , Phan BaDoi N. , Pollard Katherine S. , Pratt Henry E. , Ray David A. , Reilly Steven K. , Rosen Jeb R. , Ruf Irina , Ryan Louise , Ryder Oliver A. , Sabeti Pardis C. , Schäffer Daniel E. , Serres Aitor , Shapiro Beth , Smit Arian F. A. , Springer Mark , Srinivasan Chaitanya , Steiner Cynthia , Storer Jessica M. , Sullivan Kevin A. M. , Sullivan Patrick F. , Sundström Elisabeth , Supple Megan A. , Swofford Ross , Talbot Joy-El , Teeling Emma , Turner-Maier Jason , Valenzuela Alejandro , Wagner Franziska , Wallerman Ola , Wang Chao , Wang Juehan , Weng Zhiping , Wilder Aryn P. , Wirthlin Morgan E. , Xue James R. , Zhang Xiaomeng
Published: April 2023

Human accelerated regions (HARs) are conserved genomic loci that evolved at an accelerated rate in the human lineage and may underlie human-specific traits. We generated HARs and chimpanzee accelerated regions with an automated pipeline and an alignment of 241 mammalian genomes. Combining deep learning with chromatin capture experiments in human and chimpanzee neural progenitor cells, we discovered a significant enrichment of HARs in topologically associating domains containing human-specific genomic variants that change three-dimensional (3D) genome organization. Differential gene expression between humans and chimpanzees at these loci suggests rewiring of regulatory interactions between HARs and neurodevelopmental genes. Thus, comparative genomics together with models of 3D genome folding revealed enhancer hijacking as an explanation for the rapid evolution of HARs.
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Authors: Andrews Gregory , Fan Kaili , Pratt Henry E. , Phalke Nishigandha ,   Zoonomia Consortium§, Karlsson Elinor K. , Lindblad-Toh Kerstin , Gazal Steven , Moore Jill E. , Weng Zhiping , Andrews Gregory , Armstrong Joel C. , Bianchi Matteo , Birren Bruce W. , Bredemeyer Kevin R. , Breit Ana M. , Christmas Matthew J. , Clawson Hiram , Damas Joana , Di Palma Federica , Diekhans Mark , Dong Michael X. , Eizirik Eduardo , Fan Kaili , Fanter Cornelia , Foley Nicole M. , Forsberg-Nilsson Karin , Garcia Carlos J. , Gatesy John , Gazal Steven , Genereux Diane P. , Goodman Linda , Grimshaw Jenna , Halsey Michaela K. , Harris Andrew J. , Hickey Glenn , Hiller Michael , Hindle Allyson G. , Hubley Robert M. , Hughes Graham M. , Johnson Jeremy , Juan David , Kaplow Irene M. , Karlsson Elinor K. , Keough Kathleen C. , Kirilenko Bogdan , Koepfli Klaus-Peter , Korstian Jennifer M. , Kowalczyk Amanda , Kozyrev Sergey V. , Lawler Alyssa J. , Lawless Colleen , Lehmann Thomas , Levesque Danielle L. , Lewin Harris A. , Li Xue , Lind Abigail , Lindblad-Toh Kerstin , Mackay-Smith Ava , Marinescu Voichita D. , Marques-Bonet Tomas , Mason Victor C. , Meadows Jennifer R. S. , Meyer Wynn K. , Moore Jill E. , Moreira Lucas R. , Moreno-Santillan Diana D. , Morrill Kathleen M. , Muntané Gerard , Murphy William J. , Navarro Arcadi , Nweeia Martin , Ortmann Sylvia , Osmanski Austin , Paten Benedict , Paulat Nicole S. , Pfenning Andreas R. , Phan BaDoi N. , Pollard Katherine S. , Pratt Henry E. , Ray David A. , Reilly Steven K. , Rosen Jeb R. , Ruf Irina , Ryan Louise , Ryder Oliver A. , Sabeti Pardis C. , Schäffer Daniel E. , Serres Aitor , Shapiro Beth , Smit Arian F. A. , Springer Mark , Srinivasan Chaitanya , Steiner Cynthia , Storer Jessica M. , Sullivan Kevin A. M. , Sullivan Patrick F. , Sundström Elisabeth , Supple Megan A. , Swofford Ross , Talbot Joy-El , Teeling Emma , Turner-Maier Jason , Valenzuela Alejandro , Wagner Franziska , Wallerman Ola , Wang Chao , Wang Juehan , Weng Zhiping , Wilder Aryn P. , Wirthlin Morgan E. , Xue James R. , Zhang Xiaomeng
Published: April 2023

Understanding the regulatory landscape of the human genome is a long-standing objective of modern biology. Using the reference-free alignment across 241 mammalian genomes produced by the Zoonomia Consortium, we charted evolutionary trajectories for 0.92 million human candidate cis-regulatory elements (cCREs) and 15.6 million human transcription factor binding sites (TFBSs). We identified 439,461 cCREs and 2,024,062 TFBSs under evolutionary constraint. Genes near constrained elements perform fundamental cellular processes, whereas genes near primate-specific elements are involved in environmental interaction, including odor perception and immune response. About 20% of TFBSs are transposable element–derived and exhibit intricate patterns of gains and losses during primate evolution whereas sequence variants associated with complex traits are enriched in constrained TFBSs. Our annotations illuminate the regulatory functions of the human genome.
Seeing humans through an evolutionary lens
Authors: Romero Irene Gallego
Published: April 2023

A collection of mammalian genomes provides insights into human biology and evolution
Intracellular Vimentin Regulates the Formation of Classical Swine Fever Virus Replication Complex through Interaction with NS5A Protein
Authors: Cheng Yan , Lou Jin-xiu , Liu Ya-yun , Liu Chun-chun , Chen Jing , Yang Ming-chuan , Ye Yin-bo , Go Yun Young , Zhou Bin
Published: April 2023

Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is a highly infectious disease that poses a significant threat to the global pig industry. Therefore, gaining insights into the virus and its interaction with host cells is crucial for developing effective antiviral measures and controlling the spread of CSF.
Comprehensive Assessment of 16S rRNA Gene Amplicon Sequencing for Microbiome Profiling across Multiple Habitats
Authors: Zhang Wenke , Fan Xiaoqian , Shi Haobo , Li Jian , Zhang Mingqian , Zhao Jin , Su Xiaoquan
Published: April 2023

16S rRNA has long been used as a biomarker to identify distinct microbes from complex communities. However, due to the influence of the amplification region, sequencing type, sequence processing, and reference database, the accuracy of 16S rRNA has not been fully verified on a global range.
Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy
Authors: Ning Bangzuo , Shen Jingjing , Liu Fanglin , Zhang Hemin , Jiang Xin
Published: May 2023

Current strategies for treating drug-resistant tuberculosis have limited efficacy and undesirable side effects; hence, research on new treatments, including innovative medications, is required. Host-directed therapy (HDT) has emerged as a viable strategy for modulating host cell responses in order to enhance protective immunity against infections.
Preparation of
Trichoderma asperellum
Microcapsules and Biocontrol of Cucumber Powdery Mildew
Authors: Qi Qi , Fan Chengcheng , Wu Hongqu , Sun Lili , Cao Chuanwang
Published: April 2023

Trichoderma asperellum
is widely found in plant roots and soil and has been used for the biocontrol of various plant pathogens; however, the control efficiency of
T. asperellum
is usually unstable in field trials. To improve the control efficiency of
T. asperellum
, in the present study,
T. asperellum
microcapsules were prepared using sodium alginate as wall material to reduce the effects of temperature, UV irradiation, and other environmental factors on its activity, and to significantly improve its biocontrol efficiency on cucumber powdery mildew.
Compositional Changes in Sediment Microbiota Are Associated with Seasonal Variation of the Water Column in High-Altitude Hyperarid Andean Lake Systems
Authors: Ramos-Tapia Ignacio , Salinas Pamela , Núñez Reynaldo , Cortez Donna , Soto Jorge , Paneque Manuel
Published: April 2023

In this study, we analyzed the persistence of the water column through satellite images and physicochemical characterization to investigate the composition and diversity in High Andean Lake Systems in a hyperarid environment. In addition to the persistence of the water column, this approach can be used to analyze changes in the morphology of saline accumulations and persistence of snow or ice; for example, for establishing variable plant cover over time and evaluating the microbiota associated with soils with seasonal changes in plants.
Psychological recovery and well-being of spouses of patients with prostate cancer 5 years after primary treatment in Finland: a follow-up survey
Authors: Lehto Ulla-Sisko , Aromaa Arpo , Tammela Teuvo
Published: April 2023

Objective and setting

To study longitudinally cancer-related experiences of spouses of patients with prostate cancer and the predictors of their psychological recovery and quality of life (QOL) by following the participants of our previous survey at primary cancer treatment in a university hospital.

Design

A 5-year longitudinal cohort design.

Participants and procedure

A follow-up questionnaire was mailed to the female spouses/partners who participated in our previous survey (n=104). We quantitatively explored the spouses’ prostate cancer-related experiences since the previous survey and measured their current psychological symptom distress and well-being/QOL. Seventy-seven (74%) of the initial participants responded.

Outcomes

The main outcome measures were the spouses’ psychological recovery (psychological symptoms at the initial survey vs currently) and well-being/QOL (depressive symptoms, domains of QOL) at 5 years. We analysed their predictors with regression analyses.

Results

The treatment had been prostatectomy in 70% of the patients. Psychological distress had alleviated in 76% of spouses (p<0.001) and emotional changes decreased (p=0.02), but a deteriorating impact on the partnership (from 4% to 16%) and on sex life (‘strong impact’ from 23% to 37%) had increased. The outcomes were inversely associated with negative depression-related psychological symptoms and emotional changes either initially or at follow-up. However, some early experiences also predicted the outcomes when other factors were controlled for. Prostate cancer-related information received by the spouses from several sources (leaflets/handouts, TV/radio, internet) predicted better recovery and well-being/QOL, whereas the patients’ prostate cancer and treatment-related symptoms (pain, irritability/anger, bowel dysfunction) predicted poorer recovery and well-being/QOL in spouses.

Conclusions

A major negative impact of prostate cancer was experienced by the spouses still 5 years after primary treatment. Early prostate cancer-related experiences predicted long-term psychological recovery and QOL. Responding to the early information needs of spouses and effective symptom management for the patients are likely to enhance the spouses’ long-term recovery and well-being.
Early childhood parent-reported speech problems in small and large for gestational age term-born and preterm-born infants: a cohort study
Authors: Jee Gabrielle , Kotecha Sarah Joanne , Chakraborty Mallinath , Kotecha Sailesh , Odd David
Published: April 2023

Objective

(1) To assess if preterm and term small for gestational age (SGA) or large for gestational age (LGA) infants have more parent-reported speech problems in early childhood compared with infants with birth weights appropriate for gestational age (AGA). (2) To assess if preterm and term SGA and LGA infants have more parent-reported learning, behavioural, hearing, movement and hand problems in early childhood compared with AGA infants.

Design

Cohort study.

Setting

Wales, UK.

Participants

7004 children with neurodevelopmental outcomes from the Respiratory and Neurological Outcomes of Children Born Preterm Study which enrolled 7129 children, born from 23 weeks of gestation onwards, to mothers aged 18–50 years of age were included in the analysis.

Outcome measures

Parent-reported single-answer questionnaires were completed in 2013 to assess early childhood neurodevelopmental outcomes. The primary outcome was parent-reported speech problems in early childhood adjusted for clinical and demographic confounders in SGA and LGA infants compared with AGA infants. Secondary outcomes measured were parent-reported early childhood learning, behavioural, hearing, movement and hand problems.

Results

Median age at the time of study was 5 years, range 2–10 years. Although the adjusted OR was 1.19 (0.92 to 1.55) for SGA infants and OR 1.11 (0.88 to 1.41) for LGA infants, this failed to reach statistical significance that these subgroups were more likely to have parent-reported speech problems in early childhood compared with AGA infants. This study also found parent-reported evidence suggestive of potential learning difficulties in early childhood (OR 1.51 (1.13 to 2.02)) and behavioural problems (OR 1.35 (1.01 to 1.79)) in SGA infants.

Conclusion

This study of 7004 infants in Wales suggests that infants born SGA or LGA likely do not have higher risks of parent-reported speech problems in early childhood compared with infants born AGA. To further ascertain this finding, studies with wider population coverage and longer-term follow-up would be needed.
Monitoring multidimensional aspects of quality of life after cancer immunotherapy: protocol for the international multicentre, observational QUALITOP cohort study
Authors: Vinke Petra C. , Combalia Marc , de Bock Geertruida H , Leyrat Clémence , Spanjaart Anne Mea , Dalle Stephane , Gomes da Silva Maria , Fouda Essongue Aurore , Rabier Aurélie , Pannard Myriam , Jalali Mohammad S , Elgammal Amal , Papazoglou Mike , Hacid Mohand-Said , Rioufol Catherine , Kersten Marie-José , van Oijen Martijn GH , Suazo-Zepeda Erick , Malhotra Ananya , Coquery Emmanuel , Anota Amélie , Preau Marie , Fauvernier Mathieu , Coz Elsa , Puig Susana , Maucort-Boulch Delphine
Published: April 2023

Introduction

Immunotherapies, such as immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy, have significantly improved the clinical outcomes of various malignancies. However, they also cause immune-related adverse events (irAEs) that can be challenging to predict, prevent and treat. Although they likely interact with health-related quality of life (HRQoL), most existing evidence on this topic has come from clinical trials with eligibility criteria that may not accurately reflect real-world settings. The QUALITOP project will study HRQoL in relation to irAEs and its determinants in a real-world study of patients treated with immunotherapy.

Methods and analysis

This international, observational, multicentre study takes place in France, the Netherlands, Portugal and Spain. We aim to include about 1800 adult patients with cancer treated with immunotherapy in a specifically recruited prospective cohort, and to additionally obtain data from historical real-world databases (ie, databiobanks) and medical administrative registries (ie, national cancer registries) in which relevant data regarding other adult patients with cancer treated with immunotherapy has already been stored. In the prospective cohort, clinical health status, HRQoL and psychosocial well-being will be monitored until 18 months after treatment initiation through questionnaires (at baseline and 3, 6, 12 and 18 months thereafter), and by data extraction from electronic patient files. Using advanced statistical methods, including causal inference methods, artificial intelligence algorithms and simulation modelling, we will use data from the QUALITOP cohort to improve the understanding of the complex relationships among treatment regimens, patient characteristics, irAEs and HRQoL.

Ethics and dissemination

All aspects of the QUALITOP project will be conducted in accordance with the Declaration of Helsinki and with ethical approval from a suitable local ethics committee, and all patients will provide signed informed consent. In addition to standard dissemination efforts in the scientific literature, the data and outcomes will contribute to a smart digital platform and medical data lake. These will (1) help increase knowledge about the impact of immunotherapy, (2) facilitate improved interactions between patients, clinicians and the general population and (3) contribute to personalised medicine.

Trial registration number

NCT05626764.
Trends in prevalence and clustering of modifiable cardiovascular disease risk factors across socioeconomic spectra in rural southwest China: a cross-sectional study
Authors: Le Cai , Liu Lan , Li Guo-hui , Zhao Yi , Wu Xia , Rabkin Golden Allison
Published: April 2023

Objectives

This study aimed to determine the changing prevalence of clustering of cardiovascular disease (CVD) risk factors across socioeconomic spectra in rural southwest China.

Design

Data were collected from two waves of cross-sectional health interviews and examinations among individuals aged ≥35 years in rural China. Anthropometric measurements, blood pressure and fasting blood sugar levels were recorded for each participant.

Setting

This study was conducted in rural Yunnan Province of China.

Participants

8187 individuals in 2011 and 7572 in 2021 consented to participate in this study.

Results

From 2011 to 2021, prevalence increased of hypertension (26.1% vs 41.6%), diabetes mellitus (5.9% vs 9.8%), obesity (5.9% vs 12.0%) and central obesity (50.0% vs 58.3%) (p<0.01), while prevalence decreased of current smoking (35.2% vs 29.6%), secondhand smoke exposure (42.6% vs 27.4%) and current drinking (26.6% vs 29.6%) (p<0.01). This decade also saw an increase in the prevalence of participants with clustering of ≥2 (61.8% vs 63.0%) and ≥3 CVD risk factors (28.4% vs 32.2%) (p<0.05). These increasing rates were also observed among subgroups categorised by sex, ethnicity, education level, income level and those ≥45 years of age (p<0.05). In both 2011 and 2021, male participants and participants with a lower education level had higher prevalence of clustering of ≥2 and ≥3 CVD risk factors than their counterparts (p<0.01). Ethnic minority participants and participants with higher annual income had higher prevalence of clustering of CVD risk factors in 2011 but presented opposite associations in 2021 (p<0.01).

Conclusion

The prevalence of clustering of CVD risk factors increased substantially across all socioeconomic spectra in rural southwest China from 2011 to 2021. Future efforts to implement comprehensive lifestyle interventions to promote the prevention and control of CVD should in particular focus on men, those of Han ethnicity and those with low socioeconomic status.
Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial
Authors: Desmarets Maxime , Hoffmann Simone , Vauchy Charline , Rijnders Bart J A , Toussirot Eric , Durrbach Antoine , Körper Sixten , Schrezenmeier Eva , van der Schoot C Ellen , Harvala Heli , Brunotte Gaëlle , Appl Thomas , Seifried Erhard , Tiberghien Pierre , Bradshaw Daniel , Roberts David J , Estcourt Lise J , Schrezenmeier Hubert
Published: April 2023

Introduction

COVID-19 convalescent plasma (CCP) is a possible treatment option for COVID-19. A comprehensive number of clinical trials on CCP efficacy have already been conducted. However, many aspects of CCP treatment still require investigations: in particular (1) Optimisation of the CCP product, (2) Identification of the patient population in need and most likely to benefit from this treatment approach, (3) Timing of administration and (4) CCP efficacy across viral variants in vivo. We aimed to test whether high-titre CCP, administered early, is efficacious in preventing hospitalisation or death in high-risk patients.

Methods and analysis

COVIC-19 is a multicentre, randomised, open-label, adaptive superiority phase III trial comparing CCP with very high neutralising antibody titre administered within 7 days of symptom onset plus standard of care versus standard of care alone. We will enrol patients in two cohorts of vulnerable patients [(1) elderly 70+ years, or younger with comorbidities; (2) immunocompromised patients]. Up to 1020 participants will be enrolled in each cohort (at least 340 with a sample size re-estimation after reaching 102 patients). The primary endpoint is the proportion of participants with (1) Hospitalisation due to progressive COVID-19, or (2) Who died by day 28 after randomisation. Principal analysis will follow the intention-to-treat principle.

Ethics and dissemination

Ethical approval has been granted by the University of Ulm ethics committee (#41/22) (lead ethics committee for Germany), Comité de protection des personnes Sud-Est I (CPP Sud-Est I) (#2022-A01307-36) (ethics committee for France), and ErasmusMC ethics committee (#MEC-2022-0365) (ethics committee for the Netherlands). Signed informed consent will be obtained from all included patients. The findings will be published in peer-reviewed journals and presented at relevant stakeholder conferences and meetings.

Trial registration

Clinical Trials.gov (NCT05271929), EudraCT (2021-006621-22)
Protocol for a realist and social return on investment evaluation of the use of patient-reported outcomes in four value-based healthcare programmes
Authors: Roberts Gareth , Cahill Adele , Lawthom Charlotte , Price Martine , Blyth Christopher , Jones Carys , Mc Laughlin Leah , Noyes Jane
Published: April 2023

Introduction

There is growing recognition that in order to remain sustainable, the UK’s National Health Service must deliver the best patient outcomes within available resources. This focus on outcomes relative to cost is the basis of value-based healthcare (VBHC) and has led to interest in the recording of patient-reported outcome measures (PROMs) to measure patient perspectives on the impact of a health condition on their lives. Every health board in Wales is now required to collect PROMS as part of routine care. We will evaluate the VBHC programme implemented in a lead health board. The study aim is to understand what works about PROMs collection, for whom, in what contexts and why in a VBHC context. In addition, we will assess the social value of integrating PROMs collection into routine care.

Methods and analysis

A three-stage mixed-methods study comprising a realist evaluation integrated with social return on investment (SROI) analysis across four conditions; Parkinson’s disease, epilepsy, heart failure and cataract surgery. Workstream 1: Development of logic models, informed by a scoping review, documentary analysis, patient and public involvement (PPI), staff and key stakeholder engagement. Workstream 2: Realist evaluation building on multiple data sources from stages 1 to 3 to test and refine the programme theories that arise from the logic model development. Workstream 3: SROI analysis using interview data with patients, staff and carers, stakeholder and PPI engagement, anonymised routinely collected data, and questionnaires to populate a model that will explore the social value generated by the implementation of PROMs. Findings across stages will be validated with key stakeholders.

Ethics and dissemination

The study is approved by Wales Research Ethics Committee #5 (22/WA/0044). Outcomes will be shared with key stakeholders, published in peer-reviewed journals and presented at national and international conferences.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) licence, which permits others to distribute, remix, adapt, build on this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study
Authors: You Jia , Guo Yu , Kang Ju-Jiao , Wang Hui-Fu , Yang Ming , Feng Jian-Feng , Yu Jin-Tai , Cheng Wei
Published: April 2023

Background

Previous prediction algorithms for cardiovascular diseases (CVD) were established using risk factors retrieved largely based on empirical clinical knowledge. This study sought to identify predictors among a comprehensive variable space, and then employ machine learning (ML) algorithms to develop a novel CVD risk prediction model.

Methods

From a longitudinal population-based cohort of UK Biobank, this study included 473 611 CVD-free participants aged between 37 and 73 years old. We implemented an ML-based data-driven pipeline to identify predictors from 645 candidate variables covering a comprehensive range of health-related factors and assessed multiple ML classifiers to establish a risk prediction model on 10-year incident CVD. The model was validated through a leave-one-center-out cross-validation.

Results

During a median follow-up of 12.2 years, 31 466 participants developed CVD within 10 years after baseline visits. A novel UK Biobank CVD risk prediction (UKCRP) model was established that comprised 10 predictors including age, sex, medication of cholesterol and blood pressure, cholesterol ratio (total/high-density lipoprotein), systolic blood pressure, previous angina or heart disease, number of medications taken, cystatin C, chest pain and pack-years of smoking. Our model obtained satisfied discriminative performance with an area under the receiver operating characteristic curve (AUC) of 0.762±0.010 that outperformed multiple existing clinical models, and it was well-calibrated with a Brier Score of 0.057±0.006. Further, the UKCRP can obtain comparable performance for myocardial infarction (AUC 0.774±0.011) and ischaemic stroke (AUC 0.730±0.020), but inferior performance for haemorrhagic stroke (AUC 0.644±0.026).

Conclusion

ML-based classification models can learn expressive representations from potential high-risked CVD participants who may benefit from earlier clinical decisions.
Emergence of high-energy dynamics from cascade-baryon detections at the LHC
Authors: Celiberto Francesco Giovanni
Published: April 2023

We propose the inclusive detection at the LHC of a cascade$$\Xi ^-/\bar{\Xi }^+$$Ξ-/Ξ¯+baryon in association with a jet, as a novel probe channel for the QCD dynamics at high energies. We investigate the behavior of a selection of distributions, differential in rapidity, azimuthal angle and/or transverse momenta, calculated via the hybrid high-energy/collinear factorization encoding the full next-to-leading BFKL resummation of energy logarithms. We come out with the conclusion that the fragmentation mechanism underlying the production of$$\Xi ^-/\bar{\Xi }^+$$Ξ-/Ξ¯+baryon states leads to stabilization effects of the resummation, similar to those recently observed in the context of heavy-flavor studies within the same formalism.
Spectral interactions between strings in the Higgs background
Authors: Bochniak Arkadiusz , Sitarz Andrzej
Published: April 2023

We derive the exact form of the spectral interaction of two strings mediated by a constant scalar field using methods derived from noncommutative geometry. This is achieved by considering a non-product modification of the Connes–Lott model with two-dimensional manifolds. The analogy with the latter construction justifies the interpretation of the scalar field as being of Higgs type. Working in dimension two requires the use of the spectral zeta function instead of the Wodzicki residue techniques applicable to four-dimensional models. In the latter case, an analogous non-product geometry construction leads, for specific choices of metrics, to the so-called “doubled geometry models”, which can be thought of as a spectral modification of the Hassan–Rosen bimetric theory. We find that in dimension two, the interaction term depends explicitly on zweibeins defining the Dirac operators and only in some special cases can they be expressed solely using the metrics. The computations can be performed analytically for an arbitrary choice of zweibeins defining geometry on the two strings.
The interfacial properties and fracture behavior of the graphite (0001)/Cu (111) interface from a first–principles investigation
Authors: Wei Jiang , Yi Yanliang , Zheng Baochao , Liu Guangqiao , Li Wei , Liu Yangzhen
Published: April 2023

Interface considerably influences the properties of copper (Cu)–graphite composites. Therefore, considerable understanding of the interface is required to improve the mechanical and tribological properties of these composites. Because the graphite (0001) and Cu (111) interfaces are a good match, this study focuses on calculating the related properties of the interface structure using first–principles calculations. The parameter setting of this work is reasonable when comparing the theoretical and experimental results of the bulk Cu and graphite. Slabs of the nine-layer graphite (0001) and seven-layer Cu (111) surfaces have excellent convergence. The order of interfacial configuration stability is [Formula: see text] and HCP possesses the largest work of adhesion and smallest interface energy among the studied interface structures. Furthermore, the electron density and Mulliken population method are used to examine the interfacial bonds.
ALLEE EFFECT IN A RICKER TYPE DISCRETE-TIME PREDATOR–PREY MODEL WITH HOLLING TYPE-II FUNCTIONAL RESPONSE
Authors: EL-METWALLY H. , KHAN A. Q. , HAMADA M. Y.
Published: April 2023

In recent years, the stability of the predator–prey model subject to the Allee effect has become an interesting issue. This study investigates the effect of Allee effect on the stability of a discrete-time predator–prey model with Holling type-II functional response. Using equilibrium analysis, stability analysis and bifurcation theory, the mathematical characteristics of the proposed model are examined. Model experiences flip bifurcation and Neimark–Sacker bifurcation based on the center manifold theorem and bifurcation theory. Our analytical results are demonstrated by numerical simulations.
USER ENGAGEMENT IN HEALTHCARE LIVING LABS: A SCOPING REVIEW
Authors: CYR GENEVIEVE , POMEY MARIE-PASCALE , YUAN SHUAIQI , DIONNE KARL-EMANUEL
Published: April 2023

User engagement in innovation processes is crucial for the development of sustainable healthcare. One promising user-centred approach used to integrate users’ experiential knowledge in the development of innovations is the Living Lab (LL). However, we lack a systematic understanding of the processes, methods and factors that lead to more effective user engagement. The objective of this scoping review is to map and systematically present current research on user engagement in Healthcare Living Labs (HLLs) to enhance understanding and inspire future research. Our review shows that the level of user engagement is still low given the limited use of methods tailored to support it and that HLL are predominantly used in technology and clinical innovation. We offer a clearer depiction and description of the methods innovation managers could use to foster greater user engagement in HLL.
ADOPTION OF GREEN FINANCING STRATEGIES WITH RENEWABLE ENERGY RESOURCES FOR GLOBAL ECONOMIC GROWTH
Authors: SELVAPANDIAN GOPI , JEYAPAUL PRAVEEN PAUL , GUNABALAN BALAMURUGAN
Published: April 2023

Green financing is an emergent technology in recent days that supports the nature of environment with reduced carbon emissions. Also, the renewable energy sources or green resources are the most suitable options for improving the economic growth and sustainability of environment. Recently, many industrial organizations over the world were able to provide support to the deployment of green energy projects because it is less harmful to the environment and increases the financial development of country. Therefore, this paper objects to analyze the major effects of green financial strategies for developing the green energy projects. Moreover, it discussed about the recent trends of adopting green projects for ensuring the sustainability of environment with increased energy utilization. In addition to that, it examines various challenges and risks that are associated to the deployment of green financing strategy. The long-term financing, associated risks in project development, minimized return values, and lack of capacity are the major risks of green financing management systems. According to the recent reports, it is stated that the government sectors have an increased responsibility for funding the green projects to support the environment nature. Nevertheless, some of the public and private sectors in different countries are motivating the green energy projects by providing the financial support to the short-term and medium-term organizations for ensuring the sustainability of environment.
Geological disposal of radioactive waste in deep clay formations: celebrating 40 years of RD&D in the Belgian URL HADES
Authors: Van Geet Maarten , Bruggeman Christophe , De Craen Mieke
Published: April 2023

The option of disposing of radioactive waste deep underground has been studied in Belgium by SCK CEN since the 1970s. This led in 1980 to the construction of the HADES underground research laboratory (URL) in a clay formation, the Boom Clay, at a depth of 225 m under the premises of SCK CEN in Mol. Over the last four decades, many
in situ
experiments have been conducted in the HADES URL. These have made a significant contribution to ONDRAF/NIRAS’ research, development and demonstration (RD&D) efforts demonstrating that disposal in Boom Clay can offer a safe solution for the long-term management of high-level and/or long-lived radioactive waste. Moreover, the construction of the HADES URL itself is a demonstration that shafts and galleries can be constructed in clay at that depth. However, the HADES URL did not only contribute to the Belgian programme. Many of the
in situ
experiments have been part of international research and the laboratory has provided valuable input to the research programmes of other URLs, such as the Meuse/Haute-Marne URL in France and the Mont Terri rock laboratory in Switzerland. This paper gives a brief overview of the main contributions of the HADES URL to both national and international research into geological disposal.
Theoretical Development and Numerical Validation of an Asymmetric Linear Bilateral Control Model- Case Study for an Automated Truck Platoon
Authors: Salek M Sabbir , Chowdhury Mashrur , Rahman Mizanur , Dey Kakan , Islam Md Rafiul
Published: April 2023

In this paper, we theoretically develop and numerically validate an asymmetric
linear bilateral control model (LBCM)
, in which the motion information (e.g., position and speed) from the immediate leading vehicle and the immediate following vehicle of a subject vehicle in an automated vehicle platoon are weighted differently to determine the control inputs to the subject vehicle. The novelty of the asymmetric LBCM is that using this model all the follower vehicles in a platoon can adjust their acceleration and deceleration to closely follow a constant desired time gap to improve platoon operational efficiency while maintaining local and string stability. We theoretically analyze the local stability of the asymmetric LBCM using the condition for asymptotic stability of a linear time-invariant system and prove the string stability of the asymmetric LBCM using a space gap error attenuation approach. Then, we evaluate the efficacy of the asymmetric LBCM by simulating a closely coupled
cooperative adaptive cruise control (CACC)
platoon of fully automated trucks in various non-linear acceleration and deceleration states. We choose automated truck platooning as a case study since heavy-duty trucks experience higher delays and lags in the powertrain system, and limited acceleration and deceleration capabilities than passenger cars. To evaluate the platoon operational efficiency of the asymmetric LBCM, we compare the performance of the asymmetric LBCM to a baseline model, i.e., the symmetric LBCM, for different powertrain delays and lags. Our analyses showed that the asymmetric LBCM can handle any combined powertrain delays and lags up to 0.6 sec while maintaining a constant desired time gap during a stable platoon operation, whereas the symmetric LBCM fails to ensure stable platoon operation as well as maintain a constant desired time gap for any combined powertrain delays and lags over 0.2 sec. These findings demonstrate the potential of the asymmetric LBCM in improving platoon operational efficiency and stability of an automated truck platoon.
An Efficient Ring Oscillator PUF Using Programmable Delay Units on FPGA
Authors: Cui Yijun , Li Jiang , Chen Yunpeng , Wang Chenghua , Gu Chongyan , O’neill Máire , Liu Weiqiang
Published: May 2023

The ring oscillator (RO) PUF can be implemented on different FPGA platforms with high uniqueness and reliability. To decrease the hardware cost of conventional RO PUFs, a new design using the programmable delay units is proposed, namely, PRO PUF. The programmable interconnect points (PIPs) of programmable delay units are used to enhance the configurability. The PUF cell of the proposed design has the ability to be efficiently programmed to an RO PUF at any stage by adjusting the propagation paths of the delay units. A significant number of responses can be generated by the proposed PRO PUF while consuming fewer hardware resources. To verify the performance, the proposed design has been implemented on Xilinx FPGAs and also simulated using a standard 40nm technology. The experimental results have shown that the proposed design achieves high uniqueness, reliability, and hardware efficiency. Moreover, the PRO PUF has been evaluated using a machine learning attack, the CMA-ES attack. The results have shown that the proposed structure is more resistant to common modeling attacks when compared to conventional RO-related PUF designs.
New AIR for the Archaeological Process? The Use of 3D Web Semantic for Publishing Archaeological Reports
Authors: Derudas Paola , Nurra Federico , Svensson Andreas
Published: April 2023

The management of archaeological excavation data has been the subject of scientific debate in the last decades: critical elements have been identified, such as maintaining analytical data and the derived knowledge entangled, and other relevant aspects, like data curation, accessibility, and long-term preservation, have emerged. This study describes, illustrates, and evaluates the use of the Archaeological Interactive Report (AIR), a cutting-edge information system designed to manage excavation data that is oriented toward the 3D web semantics. AIR is a web platform for recording archaeological investigations live, an online archive that incorporates the complete dataset of the investigations, and a multimedia visualization system providing a 3D environment for data analysis and assemblages, testing interpretation hypotheses, and publishing dynamic editorialization outputs. AIR is applied and evaluated within the case study of Västra Vång (southeastern Sweden), demonstrating that it is possible to use a flexible ontological data model tailored to the archaeologists’ needs.
Revisiting Digital Divide: Teaching and Research Considerations
Authors: Deng Xuefei (Nancy)
Published: May 2023

In this editorial, I hope to start the conversation on the deepening digital divide that persists in disadvantaged communities and call upon us as information systems (IS) educators and researchers to create actionable knowledge and solutions to close the gap in the information and communications technology (ICT) access, use, and skills.
Affordances and Information Systems Research: Taking Stock and Moving Forward
Authors: Mesgari Mostafa , Mohajeri Kaveh , Azad Bijan
Published: May 2023

The term affordance appears with increasing frequency in the Information Systems (IS) literature. Nevertheless, those who study information technologies/information systems (IT/IS) via the affordance lens often have different views about its origin, meaning, and appropriate application in IS research. In turn, not spelling out the related assumptions and boundaries inherent in these diverse views may have hindered a wider and more cumulative adoption of the affordance lens in IS research. This paper offers a potential solution by (1) synthesizing the ecological psychology literature to suggest five key modules of the affordance concept relevant to IS research and (2) taking stock of IS research that has employed the affordance concept and classifying it according to its focus on three key affordance elements: IT artifact, user, and context. Finally, this paper presents a set of challenges, opportunities, and recommendations regarding how IS researchers can advance affordance-based research in the field.
Email Overload: Investigating Technology-fit Antecedents and Job-related Outcome
Authors: Tarafdar Monideepa , Wenninger Helena , Stich Jean-François
Published: May 2023

Email is the communication application most widely used in organizations. Yet, email is associated with a number of negative aspects, most prominently 'email overload' - a phenomenon that is theoretically interesting but vexing in practice because it has proved intractable to manage. We problematize the current understanding of email overload as being due to lack of understanding of its technology fit-related antecedents and job-related outcomes, and then investigate how email overload is influenced by a lack of fit between the communication applications that the organization provides to individuals and those that (1) they want, and that (2) are suitable for their tasks. We hypothesize that such lack of fit leads to email by default, defined as the perception of email being used improperly, when other communication applications would be better suited. Email by default is then hypothesized to lead to email overload. We further investigate job-related outcomes of email overload. The hypothesized relationships are supported by our findings, based on data from a two-stage, multi-method empirical study in a large manufacturing organization. The paper theoretically broadens the scholarly discourse on email overload to include novel antecedents and outcomes in the ongoing quest to establish a more complete understanding of this phenomenon.
IT Professionals' Turnaway Intention and the Role of Technostress
Authors: Brooks Stoney , Zaza Sam , Erskine Michael , Greer Timothy
Published: May 2023

The supply of global information technology (IT) workers does not meet the demand of the industry. Therefore, researchers try to distill ways to increase and retain the IT talent pipeline. Ensuring that IT professionals remain in their IT careers is an essential element of such research. The influence of technostress on job turnover is evident. Yet, we know little about the impact of technostress on career turnaway and its interaction effects on the antecedents of turnaway intention. While job turnover may negatively impact a specific organization, career turnaway has negative implications for the industry. Losing IT professionals from the field means that additional efforts toward motivating, recruiting, educating, and preparing replacement talent are needed. By examining the dynamics of technostress on IT professionals' career turnaway intention (N=512), we reveal two critical findings. First, technostress reduces the IT professional's commitment to their IT career and increases exhaustion from their IT career experience. Second, technostress moderates IT professionals' commitment to their profession and career turnaway intentions. To remedy these concerns, we provide managerial advice and provide suggestions for future research.
Simple and Controllable Preparation of Molybdenum Carbides by One-Step Co-Electrolysis of Na2MoO4 and CO2
Authors: Wu Tao , Zhang Jintao , Chen Yunfei , Jia Yongzheng , An Jialiang , Ge Jianbang , Wang Mingyong
Published: April 2023

Molybdenum carbides are the promising ceramic materials and catalysts. A new and green method for the controllable preparation of molybdenum carbides was proposed by one-step co-electrolysis of Na2MoO4 and CO2 greenhouse gas in carbonate molten salts. The solubility and decomposition thermodynamics of Na2MoO4 were analyzed. The structure, composition, current efficiency, energy consumption and extraction ratio of molybdenum carbide were effectively regulated by changing the molten salt composition, electrolytic voltage, temperature, and electrolytic time. It was confirmed that MoC, Mo2C or dual-phase MoC-Mo2C can be controllably prepared. Molybdenum carbides may be mainly obtained by the thermal reaction between C from CO2 and Mo from Na2MoO4. Molybdenum carbides prepared at 850 °C and 4.5 V in Na2CO3-K2CO3−32 wt% Li2CO3−15 wt% Na2MoO4 molten salts showed the best electrocatalytic activity for hydrogen evolution reaction. The work provides an innovative and sustainable strategy to prepare molybdenum carbides and utilize CO2.