bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor-Faktor yang Mempengaruhi Persepsi Wakif Wakaf Uang di Jember
Authors: Yuliati Lilis , Rochmaningsih Ayuninda , Hardinawati Lusiana Ulfa
Published: March 2024

The current potential of cash waqf can be a solution to education problems in Indonesia. with the collection of cash waqf it can provide new hope for people who are unable to take education up to college. The purpose of this research is to look at the factors that influence the perception of waqf of cash waqf, especially in Jember Regency. This research uses descriptive quantitative research methods with logistic regression analysis tools, the intended factors include four variables namely education, understanding of waqf, religiosty, and access to media and information. Based on the results of the reasearch conducted, it found that two variables affect the perception of wakif on cash waqf. The variables that have an effect are the level of understanding of waqf and the religiosity with that significance are 0,035 and 0,023. While the variables of education adn access to media and information get the significance effect get the result 0,367 and 0.948.
Penerapan Digital Marketing Sebagai Strategi Peningkatan Penjualan Skincare Herbal SR12
Authors: Muflikhata Fivtinima Wya , Fadly Wirawan
Published: March 2024

This research is motivated by the significant turnover obtained from the leading distributors and agents through digital marketing strategies. SR12 (Skin Relieve 12) Herbal Skincare only in Ponorogo. This study uses field research using a qualitative approach, with data collection techniques through observation and interviews. This writing aims to find out how to apply Islamic digital marketing strategies in increasing sales of SR12 Herbal Skincare products, how the results of implementing Islamic SR12 Herbal Skincare Islamic digital marketing strategies, and analysis of inhibiting and supporting factors of SR12 Herbal Skincare Islamic digital marketing strategies. The results showed the application of the Islamic digital marketing strategy SR12 Herbal Skincare in increasing their sales using digital social. While the development of implementing this Islamic digital marketing strategy is that SR12 Herbal Skincare is carried out with a design that includes segmenting, targeting, and positioning (STP). In carrying out the process, the company covers a wide range, while the inhibiting factors include using digital social media, each of which has obstacles.
Implementasi Etika Bisnis Islam pada Pemasaran Marketplace Shopee
Authors: Imron Yudha Nur , Masykuroh Ely
Published: March 2024

This field of qualitative research aims to examine global Islamic online marketing strategies on Shopee. This study used data mining methods for examination, classification, verification, analysis, and conclusion. The research found that Shopee's strike price system for online selling and buying follows the Islamic business ethics axiom of unity ethics and free will. Marketing does not discriminate, and he has tried to boost sales as a businessman. Sellers play a drastic price game by raising the price before the strike price. That can hurt other markets and consumers. Online marketing using a promotional system to buy and sell on Shopee Marketplace does not violate the ethical principles of unity and free will. The promotion is not coercive because it applies to all consumers. It has reduced losses on its Shopee Marketplace products. Balance, accountability, and truth are incompatible with Islamic business ethics because this marketing relies on positive testimonials from consumers or delivery couriers. The Shopee marketplace's quality system of goods conforms to the ethical hypothesis of unity and free will because sellers use some goods for bonus systems or strike prices to reduce losses for all consumers such as violates balance, accountability, and truth because the product is nearly expired and doesn't match the promotion's description.
Perilaku Konsumen dalam Berinvestasi Emas Digital Melalui Platform Tokopedia
Authors: Indrawati Titis , Damanuri Aji , Maharani Shinta
Published: March 2024

Tokopedia is an e-commerce that has a gold investment feature, namely Tokopedia Gold,which collaborates with Pegadaian. Tokopedia is the most popular e-commerce in Indonesiawith the number of monthly web visitors reaching 147.8 million in the second quarter of 2021beating other e-commerce. Tokopedia Gold Pegadaian uses a cash & wadi'ah sale andpurchase contract. Since the Tokopedia Emas feature was launched in 2018, the trend ofbuying gold transactions at Tokopedia has increased by almost 30 times, even though thespread of Tokopedia Gold, which works with Pegadaian, is 4.5% higher than direct goldinvestment at Pegadaian Digital, which is around 3%. It is necessary to know what are thefactors that influence consumer behavior in deciding to choose digital gold at Tokopedia. Thisresearch is a qualitativeresearch. Data collection techniques through interviews, observation,and documentation. Analysis with the theory of consumer behavior. The purpose of this studyis to analyze the mechanism of digital gold investment, to analyze the factors that influenceconsumer behavior in investing in digital gold, and to analyze the impact of digital goldinvestment in Tokopedia on consumer behavior. The results of the study show that the digitalgold investment mechanism influences consumer behavior because it is quite easy andpractical from the choice of product, brand, dealer, time of purchase, purchase amount, andpayment method. Factors that influence consumer behavior, namely consumer psychologicalfactors, are the most influential in investing in digital gold at Tokopedia. Then culturalfactors have a fairly good influence, but social and personal factors have little influence. Aswell as investing in gold has both positive and negative impacts, the many conveniencesoffered, especially attractive promos, make consumers satisfied making purchases, therebyinfluencing consumer behavior to invest in digital gold on Tokopedia continuously.
Transaksi Bisnis Game Axie Infinity di Bungkal Perspektif Etika Bisnis Islam
Authors: Rahma Mevianti Nur , Masykuroh Ely , Wahyudi Amin
Published: March 2024

Online games that carry the theme of  the play-to-earn movement  have become a new phenomenon in the game industry because they can be used for a business. One of the games that developed into a business is the Axie Infinity game. The research method is a qualitative descriptive, field research approach with data obtained from interview data collection and documentation. The results of this study are 1) The practice of Axie Infinity game business transactions is carried out in two ways, namely  through the Axie Infinity marketplace and through the intermediary of the Axie Family community leader. Both ways of business transactions are contrary to the principles or axioms of Islamic business ethics, which are not in accordance with the principles of tawhid, balance or justice, free will, and responsibility. 2) Factors that affect the business transactions of the Axie Infinity game include interpretation factors of the law, organizational factors, and individual factors or certain condition situations. 3) The play of Axie Infinity game done by players has an impact on the game players. Impact can be in the form of impacts on economic, social, impact on physical health, psychological aspects, time aspects, and financial aspects. In general, the business does have an impact on increasing player income, but the income obtained is erratic and risks player losses.
Internalisasi Solidaritas Sosial dan Nilai-Nilai Islam melalui Tradisi Weweh
Authors: Al Hidaya Ardian
Published: March 2024

Weweh is a hereditary tradition that is still practiced by the community, especially in Java, by delivering food to relatives ahead of Eid al-Fitr. Qualitative research with an ethnographic approach aims to describe how the weweh tradition contributes to maintaining and encouraging social solidarity among the community and how this role is related to Islamic values in Sawahan Village, Sawahan Sub-district, Madiun Regency. The results show that weweh is usually performed after the night of 21 Ramadan until the day before Eid. There has been a modification of the food (wewehan) given for weweh from processed food consisting of rice, various vegetables, and side dishes such as opor and roast chicken arranged in rantang susun to gifts or parcels consisting of raw food ingredients such as cooking oil, sugar, coffee, tea, candy, biscuits, pastries, and instant noodles. Children of younger relatives are usually the ones who deliver the gifts to the homes of the older relatives who are given wewehan. The relatives who receive the wewehan usually give the money and or food back in the giving container. The weweh tradition teaches generosity through food alms, friendship, maintaining cultural heritage, strengthening a sense of kinship and social solidarity, and is able to provide a sense of happiness for the giver and recipient of wewehan, especially if the wewehan recipient is a poor person who will be helped by the presence of food or food ingredients to welcome the Eid celebration. It is proven that this weweh tradition impacts the internalization of social solidarity with the content of Islamic values in the community.
WITHDRAWN: Addressing social determinants of health is a priority for managing COVID-19 in Arctic Indigenous communities: results of a scoping review
Authors: Kolahdooz Fariba , Jang Se Lim , Deck Sarah , Ilkiw David , McKeen Jennifer , Omoro Gertrude , Rautio Arja , Pirkola Sami , Moeller Helle , Ferguson Gary , Evengard Birgitta , Mantla-Look Lianne , Milligan Crystal , DeLancey Debbie , Corriveau Andre , Irlbacher-Fox Stephanie , Wagg Adrian , Roache Cindy , Oystrek Rachel , Rittenbach Katherine , Conter Henry J , Falk Ryan , Kurtz Donna , Sharma Sangita
Published: March 2024

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Dispositional mindfulness: Is it related to knee osteoarthritis population’s common health problems?
Authors: Chu Su-Feng , Lin Li-Chen , Chiu Aih-Fung , Wang Hsiu-Hung
Published: March 2024

Background: A growing body of research supports dispositional mindfulness as important in influencing physical and mental health as well as physical activities in patients with chronic illnesses. Knee osteoarthritis (OA), which often causes health problems, is one of the most common chronic illnesses, but less is known about dispositional mindfulness in relation to this condition.
Objective: To explore possible associations between dispositional mindfulness and physical and mental health as well as physical activity in knee OA patients.
Methods:For this cross-sectional study, we recruited a purposive sample of orthopedic clinic patients in hospitals in Southern Taiwan. Instruments included the Mindful Attention Awareness Scale (MAAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Health-related characteristics were also measured. Demographic statistics, bivariate correlations, and multiple linear regression informed our exploration of potentially related factors for dispositional mindfulness.
Results: Participants with knee OA (N = 250) were mostly elderly (88%), female (70.5%), and married (84%). Marital status, perceived health status, depression, and physical activity were associated with dispositional mindfulness. Better perceived health, lower depression, and greater physical activity were significantly associated with greater dispositional mindfulness. However, the severity of symptoms, fear of falling, and exercise self-efficacy did not reach statistical significance in relation to dispositional mindfulness.
Conclusion: Greater emphasis should be placed on the cultivation of mindfulness to enhance individuals’ perceived health, decrease their depressive mood, and promote their engagement in physical activity, which could indirectly alleviate their experience of pain and improve their physical function, yielding better quality of life and well-being. Future research should focus on interventions to apply dispositional mindfulness in order to determine whether dispositional mindfulness can effectively improve physical and mental health as well as physical activity in those with knee OA.
RETRACTED: Robust and Secure Video Authentication: A Hash-Based Watermarking Approach
Authors: Saini Preeti , Ahuja Rakesh
Published: March 2024

The authors have requested that this preprint be removed from Research Square.
Artificial Neural Networks for PIO Events Classification Comparing Different Data Collection Procedures
Authors: Bruschi Adriano Ghigiarelli , Drewiacki Daniel , Bidinotto Jorge Henrique
Published: March 2024

This work evaluates the accuracy and reliability of PIO test classification using the PIO Rating Scale and proposes using an automatic tool for this evaluation based on test data to eliminate the subjectivity inherent to the application of rating scales. Two test procedures (Discrete Synthetic Task and Pitch Capture) are executed in a flight simulator, using aircraft dynamic models with different PIO proneness and experienced flight test pilots. The results show a significant effect of subjectivity in pilot rating and various reliability for different test procedures. This data is used to build an Artificial Neural Network (ANN) proposed to classify the executions using the PIO Rating Scale. The ANN presented low computational cost and 97.1% accuracy when using data extracted from the Pitch Capture test procedure.
Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans
Authors: Katsu Yoshinao , Zhang Jiawen , Baker Michael E.
Published: March 2024

Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame insertion of 12 base pairs coding for Lys, Cys, Ser, Trp (KCSW) in their DNA-binding domain (DBD) and the presence of two amino acid mutations in their amino terminal domain (NTD). Two human MRs with the KCSW insertion (MR-KCSW) and three human MRs without KCSW in the DBD have been identified. The three human MRs without KCSW contain either (Ile-180, Ala-241) or (Val-180, Val-241) or (Ile-180, Val-241) in their NTD. The two human MRs with KCSW contain either (Val-180, Val-241) or (Ile-180, Val-241) in their NTD. Human MR-KCSW with (Ile-180, Ala-241) has not been cloned. In contrast, chimpanzees contain two MRs with KCSW and two MRs without KCSW in their DBD and both contain only Ile180, Val-241 in their NTDs. Each pair of chimpanzee MRs differ at another amino acid in the NTD. A chimpanzee MR with either Val-180, Val-241 or Ile-180, Ala-241 in the NTD has not been cloned. Gorillas and orangutans each contain one MR with KCSW in the DBD and one MR without KCSW. Both gorilla and orangutan MRs contain I-180, Val-241 in their NTD. Neither Val-180, Val-241 nor Ile-180, Ala-241 are found in the NTD in either a gorilla MR or an orangutan MR. These data suggest that human MRs with Val-180, Val-241 or Ile-180, Ala-241 in the NTD evolved after humans and chimpanzees diverged from their common ancestor. These unique human MRs may have had a role in the divergent evolution of humans from chimpanzees. Studies are underway to characterize transcriptional activation of the five human MRs by aldosterone, cortisol, and other corticosteroids for comparison with each other to elucidate the roles of these MRs in human physiology.
Influences of size effect and workpiece temperature during cryogenic micro milling of soft viscoelastic polymer: An experimental assessment
Authors: Mallick Partha Sarathi , Patra Karali
Published: March 2024

It is necessary to create different micro-features on stretchable polymers for making sensing components in wearable sensors, and to make them work like human tissue. Such micro-features are currently fabricated through soft lithography process that requires long processing time. However, tool based micromachining which is faster and able to create any customized and complex structures has not yet been applied as soft polymer shows high adhesion and low elastic modulus at room temperature. This study aims to evaluate the machinability of typical viscoelastic soft polymer and understand the effect of material and process parameters on machining performances. In this study, a mechanical micro milling process using cryogenic assisted cooling is proposed and the importance of temperature control towards glass transition zone was particularly addressed. To identify insight of machinability in micro domain, this article also determines minimum uncut chip thickness (MUCT) and size effects by considering the variations of cutting force and surface integrity with the ratio of h/re (uncut chip thickness (h) to cutting edge radius (re)). The experimental results reveal that consideration of size effect during micro milling of soft viscoelastic polymer helps in reduction of machined surface roughness (Sa) value. Based on the cutting force pattern, it is evaluated that higher machining stability can be achieved during cryogenic machining by reduction of specific cutting force value. By control tuning of temperature, machining performances exact at glass transition temperature zone show more promising experimental results compared to other cooling zones.
Synergistic effect of Fe-amorphous and bionic microtexture in enhancing high-temperature tribological properties of Al-12Si piston materials
Authors: Wang Yingdong , Lin Zuxiang , Yin Chengbin , Kong Detong , Zhao Deyong , Wang Zhijun , Ma Beibei , Xu Zehua , Wang Yuan
Published: March 2024

This study designs new Fe-amorphous/Al-12Si piston composite materials. Study the effect and synergistic mechanism of the addition of Fe-amorphous and bionic micro-textured laser surface on the high-temperature friction performance of Al-12Si piston material under mixed lubrication conditions of B30 biodiesel and engine lubricating oil. The results indicate that the frictional properties of the untextured surface of the Fe-amorphous/Al-12Si composite material depend primarily on the amount of Fe-amorphous added. The 10 wt% Fe-amorphous/Al-12Si composite exhibits a dense, void-free microstructure with optimum anti-friction and anti-wear performance. It is noteworthy that the interaction between the "anchoring" effect caused by the Fe-amorphous addition and the synergistic effect of the bionic microtexture providing a stable lubricating environment further enhances the high-temperature friction properties of Al-12Si.
Administrative challenges facing the Cuban-South African medical collaboration at the University of KwaZulu-Natal
Authors: Chinniah Valerie , Maharaj Ashika
Published: March 2024

The Cuban-South African medical collaboration is a government initiative that started in the early nineties to supplement the shortage of doctors in the country. The scarcity of medical doctors especially in remote and rural locations has an impact on the achievement of health related outcomes for universal health coverage in South Africa. Previous studies in this area have focused on the competencies (Motala, 2014), cost effectiveness (Mqadi, 2015) and appropriateness of the training of South African students in Cuba and in most cases, has been from the perspective of the students in the programme (Motala & van Wyk, 2016). The aim of this study was to identify the challenges facing the Cuban-South African medical collaboration at programme-level at the University of KwaZulu-Natal. Students from the Cuban cohort have to return to a South African medical university to complete their training and register with the Health Professions Council of South Africa in order to practice as a doctor. A qualitative exploratory study was conducted using the interpretive epistemology approach to highlight the challenges facing programme administrators at the University of KwaZulu-Natal. The collection of data was done using semi-structured interviews from participants selected from the Nelson R Mandela School of Clinical Medicine, UKZN. Purposive snowball sampling was implemented to select the key personnel employed to administer and manage the Cuban collaboration programme. Data was analysed using thematic analysis and organised on Nvivo to highlight important themes in the study. Challenges related to administration, logistics, language, connectivity and Covid-19 issues were discovered to be a major impediment to the programme’s smooth operation. Recommendations to address the challenges should assist in improving the overall experience for cohort students who are the key role players for human resources for health, health reforms and primary health care in South Africa.
Efficacy Testing of Bio-fertilizer Based on Azotobacter on Sweet Corn (Zea mays convar)
Authors: Mishra Prateek , Sharma Surbhi , Kumar Shravan , Singh Anjali
Published: March 2024

Excessive utilization of agrochemical fertilizers significantly leads to the decline of soil quality and its flora, it also affect human health. A material called bio-fertilizer contains living microorganisms that are advantageous to the growth and development of plants.Due to the impact of biofertilizers on enhancing crop yield, there is a growing focus on exploring beneficial microbes as biofertilizers within the agricultural domain. Consequently, this study was carried out to assess the efficacy of Azotobacterbiofertilizer on Sweet Corn (Zea mays convar).An experiment in a controlled artificial greenhouse setting involved 21 different treatments utilizing varying quantities of inoculants and carrier materials to create biofertilizer. The carrier material, derived from locally accessible raw materials such as cow dung, leaf litter, peat soil, lignite, charcoal, and vermiculite, serves as a substrate capable of hosting microbial inoculants and maintaining their viability for a specific duration, while also being easily accessible to farmers. Following the sowing of sweetcorn seeds for a month, the resulting germinated plants underwent analysis for parameters including plant height, stem girth, leaf count, length and width of leaves, as well as root length.The quantity of seed germination and the duration required for seeds to germinate were also recorded. Out of the 21 treatments, ST11, comprising 400 ml of inoculants combined with 300 g of carrier material, displayed higher values for plant parameters compared to the other treatments, although the statistical significance among all treatments was minimal. Each plant parameter responded differently to the various treatments. Contrary to the findings of others, the seeds immersed in microbial inoculant (ST2) did not notably enhance plant growth except for the number of leaves per plant. To validate the effectiveness of the formulated biofertilizer, a control was established: one set of seeds were sown solely in pot soil, while another contained only carrier material (ST21) without any microbial inoculant, which did not facilitate plant growth. Overall, plants treated with biofertilizer exhibited a positive response in terms of plant growth compared to the control group.
PEMOCS: Evaluating the effects of a concept-guided, PErsonalized, MOtor-Cognitive exergame training on cognitive functions and gait in chronic Stroke – study protocol for a randomized controlled trial
Authors: Huber Simone K. , Knols Rudolf H. , Held Jeremia P.O. , Betschart Martina , de Bruin Eling D.
Published: March 2024

Background
Many stroke survivors remain with residual cognitive and motor impairments despite receiving timely acute and sub-acute rehabilitation. This indicates that rehabilitation following stroke should be continuous to meet the needs of individual stroke patients. Both, cognitive and motor functions are essential for mastering daily life and, therefore, should be aimed at with rehabilitation. Exergames, motor-cognitive exercises performed using video games, are an auspicious method to train both, motor and cognitive functions, and at the same time may foster the long-term motivation for training. This study aims to assess the effect of concept-guided, personalized, motor-cognitive exergame training on cognitive and motor functions in chronic stroke survivors.
Methods
This study is a single-blinded, randomized controlled trial. Assessments are performed at baseline, after a 12-weeks intervention and at a 24-weeks follow-up. Chronic stroke patients (≥ 18 years old, ≥ 6 months post-stroke) able to stand for three minutes, independently walk ten meters, follow a two-stage command, and without other neurological diseases apart from cognitive deficits or dementia, are included. Participants in the intervention group perform the exergame training twice per week for 30 (beginning) up to 40 (end) minutes additionally to their usual care program. Participants in the control group receive usual care without additional intervention(s). Global cognitive functioning (total Montreal Cognitive Assessment (MoCA) score) is the primary outcome. Secondary outcomes include health-related quality of life, specific cognitive functions, single- and dual-task mobility, and spatiotemporal gait parameters. Linear mixed models with the post-outcome scores as dependent variables, and group and time as fixed effects will be performed for analysis.
Discussion
Superior improvements in global cognitive functioning, and in the above mentioned secondary outcomes in the intervention group compared to the control group are hypothesised. The results of this study may guide future design of long-term rehabilitation interventions after stroke.
Trial registration
clinicaltrials.gov (NCT05524727). Registered on September 1st, 2022.
A new perspective on future precipitation changes in Tanzania
Authors: Gleixner Stephanie , Lehmann Jascha , Gornott Christoph
Published: March 2024

Tanzania's population and economy is very vulnerable to precipitation changes and extremes and therefor it is highly relevant to give reliable information about future precipitation changes for suitable adaptation planning. However, there is a strong disagreement between climate models for future precipitation changes in the region, which limits local trust in the projections. We break down the assessment of precipitation changes by classifying different precipitation categories using the Standardized Precipitation Index (SPI). With this novel approach, we analyse the projections from the CORDEX Africa Ensemble and find that despite the disagreement in the trend of total precipitation, most models project a robust decrease in “normal” conditions as well as a robust increase in both extreme wet and extreme dry conditions throughout the 21st century. The differences between the models in terms of total precipitation are related to shifts of (near) normal conditions to wetter conditions in the case of wet models and to drier conditions for dry models. The results indicate an overall broadening of the rainfall distribution especially toward extremely wet conditions. Such robust results can contribute to build trust in climate projections for adaptation planning.
Ultrasound Powered Wetting and Filling of Liquid Metal into Ultrafine Channels for Flexible Electronics
Authors: Ma Xing , Xu Zirong , Jin Dongdong , Liu Sanhu , Li Guoqiang , Guo Zichang , Li Zhengwei , Xiong Chengqian , Xu Zhiwu
Published: March 2024

Liquid metals (LMs) that possess both metallic and fluidic properties at room temperature promise numerous benefits in flexible electronics. However, preparing fine LM circuits with complex architectures at the microscale and below poses great challenges due to large surface tension of LMs, hindering the development of flexible electronic devices with increased integration and/or complexity. Herein, we develop a facile strategy that employs ultrasonic stimulation to power the wetting and filling of LMs into non-wettable elastic microchannels for ultrafine LMs circuits fabrication. Taking advantage of ultrasound-induced asymmetrical acoustic pressure within LMs, rapid and complete filling of LMs into microchannels as fine as ~ 750 nm could be achieved within several seconds without destroying the soft substrate. Electromechanical investigations suggested that the LM-filled microchannels by ultrasound possessed excellent cyclic stability and robustness. Through ultrasonic filling and patterning ultrafine LM circuits, we created a miniaturized pressure sensor array capable of accurately sensing load pressure and spatial information. The sensitivity of the finger-wearable strain sensor was further enhanced by 22.6 times via introducing local microstructures and filling LM inside the microchannel. Finally, we demonstrated the efficient preparation of complex LM circuit patterns powered by ultrasound, e.g., integrated circuits, spiderman, and snowflake patterns with multiple interlaced branches, planar structures, blind holes as well as vertical architectures, all of which could hardly be achieved by conventional injection methods. This work presented an ultrasound-based fabrication method for versatile LMs circuits, providing a platform technology for the advancement of next-generation compact and integrated flexible electronics.
Deciphering Hydrochemical Characteristics and Formation mechanism of Groundwater in the Pongo Iron Mine Area, Peru
Authors: Ge Qin , Wang Huiman , Wan Sheng , Wu Ping , Adimalla Narsimha , Li Xiang , Mi Zhenhua , Li Xinyan , Wang Yang
Published: March 2024

Understanding the hydrochemical characteristics and formation processes of groundwater in mining areas is crucial for protecting and utilizing underground water resources. This study analyzed 42 groundwater samples from the Pongo mining area in Peru to determine the spatial-temporal distribution patterns and formation processes of chemical components. Statistical analysis, Gibbs diagrams, ion ratios, and hydrogeochemical modeling techniques were used. The results show that the groundwater in the study area is weakly alkaline (pH = 7.72) and has a total dissolved solids (TDS) range of 253.19 to 17912.82 mg/L, with an average of 2788.31 mg/L. About 55% of the groundwater samples are classified as brackish or saline water. According to the Gibbs diagram, the chemical composition of groundwater is mainly controlled by evaporation and rock weathering. Furthermore, ion ratios indicate the contribution of human activities, oxidation of pyrite, and desulfurization reactions to ionic concentrations in this groundwater system. The dissolution of evaporite minerals such as halite and gypsum contributes to the presence of Na+, Cl−, and SO42−, while Ca2+ and Mg2+ mainly come from the dissolution of minerals like calcite, gypsum, dolomite, and silicate. It is worth noting that approximately 38% groundwater samples have recorded NO3− concentrations levels surpassing the standard limit of 10 mg/L for drinking purpose, which is mainly attributed to agricultural activities. Moreover, the hydrogeochemical modeling indicates a strong dissolution tendency for halite and propensity for dissolution for gypsum, calcite, and dolomite. Additionally, pyrite oxidation and cation exchange processes also occur.
Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node
Authors: Buchwald Zachary , Shen Yang , Connolly Erin , Aiello Meili , Zhou Chengjing , Chappa Prasanthi , Song Haorui , Tippitak Patan , Clark Tarralyn , Cardenas Maria , Prokhnevska Nataliya , Mariniello Annapaola , Pagadala Meghana , Dhere Vishal , Rafiq Sarwish , Kesarwala Aparna , Orthwein Alexandre , Thomas Susan , Khan Mohammad , Dixon J. Brandon , Lesinski Gregory B. , Lowe Michael , Kissick Haydn , Yu David , Paulos Chrystal , Schmitt Nicole
Published: March 2024

Radiotherapy (RT) and anti-PD-L1 synergize to enhance local and distant (abscopal) tumor control. However, clinical results in humans have been variable. With the goal of improving clinical outcomes, we investigated the underlying synergistic mechanism focusing on a CD8+ PD-1+ Tcf-1+ stem-like T cell subset in the tumor-draining lymph node (TdLN). Using murine melanoma models, we found that RT + anti-PD-L1 induces a novel differentiation program in the TdLN stem-like population which leads to their expansion and differentiation into effector cells within the tumor. Our data indicate that optimal synergy between RT + anti-PD-L1 is dependent on the TdLN stem-like T cell population as either blockade of TdLN egress or specific stem-like T cell depletion reduced tumor control. Together, these data demonstrate a multistep stimulation of stem-like T cells following combination therapy which is initiated in the TdLN and completed in the tumor.
The availability of thermal refuges shapes the thermoregulatory behavioural tactic of a heat-sensitive alpine endotherm species.
Authors: Malagnino Alexis , Courbin Nicolas , Bonnot Nadège , Garel Mathieu , Marchand Pascal , Morellet Nicolas , Börger Luca , Loison Anne
Published: March 2024

With the ongoing rise in global average temperatures, animals are expected to increasingly dedicate their time and energy to thermoregulation. In response to high temperatures, animals typically either seek for and move into thermal refuges, or reduce their activity during the hottest hours of the day. Yet, the often lower resource availability in thermal refuges, combined with the reduction of foraging activity, may create indirect energetic costs of behavioural thermoregulation, forcing individuals to further adjust their behaviours under different spatial contexts. To elucidate such complex behavioural responses of individuals living in different landscapes, we studied how alpine chamois behaviour (Rupicapra rupicapra), a cold-adapted endotherm, varied in relation to both temperature and within-home range access to thermal refuges. We used Hidden Markov Models to analyse individual time-budgets and daily habitat use of 26 GPS-tagged females monitored during summer in the French Alps. Females showed heat stress avoidance behaviours above a threshold temperature of 17.8°C, increasing the use of forest and northern slopes by 2.8% and 2.2%, respectively, for each 1°C increase in temperature. Individuals with access to forests also increased daily time spent foraging, while individuals with access to northern slopes increased the time spent relocating at the expense of foraging. Including local landscape context and jointly analysing resource selection and behavioural activity is hence key for improved insights into nuanced changes in individual responses to climate change in different spatial contexts, providing also an improved evidence base for wildlife managers to identify and protect key thermal cover habitats.
In vitro Gas production and rumen fermentation for rations containing increasing levels of Panicum maximum cv. Mombasa with or without Spirulina
Authors: meteab mohamed , Khorshed Mahmoud Mohamed , El-Essawy Abeer Mohamed Abd El-halim , Nassar Mahmoud Saber Mahmoud , El-Bordeny Nasr El -Sayed Yehia Mohamed
Published: March 2024

This study aimed to evaluate the impact of replacing alfalfa hay with Panicum maximum hay, with or without ascending levels of Spirulina supplementation on in-vitro gas production and fermentation parameters. Isocaloric and isonitrogenous experimental diets were formulated to contain 40% roughage + 60 % concentrate, ascending replacement with Panicum maximum hay at levels 0, 25%, 50%, 75%, and 100% take place in rations R1, R2, R3, R4, and R5, respectively. Each ration supplemented with incremental levels 0, 0.5, 1.5, 2, 2.5, and 3kg spirulina per Ton of feed. Results indicated that the potential of gas production after 24 h was linearly increased by increasing the level of Spirulina. The control group (R1) recorded the highest values of gas production, while it was the lowest at (R5) (p<.0001). In vitro degradability of dry and organic matter was negatively affected by the increment of Panicum maximum and Spirulina levels and vice versa, until 2 kg/ton of Spirulina (p<.0001). The addition of Spirulina significantly (p<.0001) increased total volatile fatty acids (TVFA) and N-NH3 concentration, until 2Kg/ton, while the addition of Panicum maximum hay significantly increased N-NH3 concentration, until it reached at (R4). As a result, the best mixing ratio between Alfalfa and Panicum maximum hays was recorded at R2. In conclusion, the substitution of alfalfa hay with 25% Panicum maximum hay (R2) and incorporation of Spirulina as feed additive (2Kg/ton) could offer a good solution in dry periods to improve the quality of Panicum maximum and can be used to maximize degradability and ruminal fermentation parameters.
A novel concept for multi-objective optimization of composite power transmission shafts
Authors: Nasr Mohamed , Maalawi Karam Y. , Bayoumi Mahmoud A. EL
Published: March 2024

Shafts made of advanced composite materials and their applications in different fields are gaining momentum due to their optimized properties. This paper presents various multi-objective optimization (MOO) models for the structural design of slender, thin-walled spinning shafts made of advanced composite materials. The proposed mathematical formulation ensures the attainment of simultaneous and balanced improvements in the major design objectives, including minimal mass and maximum stability against whirling and torsional buckling under behavioral and side constraints. A hybrid genetic algorithm (GA) and sequential quadratic programming (SQP) are implemented to find the needed optimal solutions. Design variables encompass the fiber volume fraction, orientation angle, and thickness of each layer of the cross-section. A case study addresses the optimization of a pinned-pinned slender shaft made of carbon/epoxy composites is presented. The new approach exhibited its capacity to overcomes the uncertainty in ranking and selecting a solution from the set of Pareto-optimal solutions as it determines a unique optimal solution that has a nearly equal optimization gains for the selected design objectives
One size fits all? A latent Profile Analysis to Identify Care Professional Subgroups Based on Implementation Determinants
Authors: Dubbeldeman Eveline M , Kleij Rianne MJJ van der , Jong Jessica C Kiefte-de , Diderich Hester M , Gerding Isabelle LL , Crone Mathilde R
Published: March 2024

Introduction: Recent research emphasizes the need for a more holistic approach to implementation science, ackonowledging complex interactions among implementation determinants and heterogeneity in context and care professionals (CPs). To verify this need, we aimed to identify distictive subgroups of CPs based on their unique profiles of implementation determinants concerning the Childcheck, a guideline facilitating early identification of child abuse based on parental characteristics. We also explored the influence of organization type on subgroups of CPs with specific implementation characteristics (subgroup membership) and assessed their relationship to CPs implementation level.
Methods: A total of 562 Dutch CPs in Mental Health Care (aMHC) and Forensic Care settings (Forensic MHC, Probation Service, and The Salvation Army) completed a self-reported questionnaire on Childcheck implementation determinants. We conducted Latent Profile Analysis to identify subgroups of CPs. The influence of organization type on subgroup membership was examined using Chi-Squared test and we explored the impact of subgroup membership on implementation levels using a one-way ANOVA.
Results: We identified five distinct subgroups. Subgroup A (Reporting Center for Child Abuse and Neglect (RCCAN) collaboration issues, 11.7%) faced issues related to the external organization, such as feedback and collaboration issues. Subgroup B (RCCAN collaboration and organizational issues, 5.0%) encountered challenges with both the external and internal organization, including issues with financial resources and formal agreements, resulting in the lowest implementation level. Subgroup C (Limited implementation issues, 9.4%) demonstrated relatively high ratings across determinants, achieving the highest implementation level. CPs in subgroup D (CP-client interaction issues, 37.7%) encountered challenges specifically in CP-client interaction. CPs in subgroup E (Indifferent attitudes towards implementation, 36.1%) expressed low to average retings and was predominantly represented by CPs in aMHC settings. This subgroup also reported a low to average implementation level.
Conclusions: This study highlights the importance of tailored implementation plans to address each subgroup's specific needs and challenges, instead of employing a one-size-fits-all approach. Latent Profile Analysis successfully revealed the variations in implementation determinants among CPs in aMHC and Forensic Care settings. Tailoring implementation strategies for these subgroups is key to successful guideline implementation and enhancing the well-being of vulnerable children and families.
The Effect of Modified Qiyuan Paste on Mice with Low Immunity and Sleep Deprivation by Regulating GABA Nerve and Immune System
Authors: Rong Mei , Jia Jiu Jie , Lin Min Qiu , He Xing Li Shang , Xie Zhi Yi , Wang Ning , Zhang Ze Hua , Dong Ying Jie , Xu Wan Feng , Huang Jia Hui , Li Bo , Jiang Ning Hua , Lv Gui Yuan , Chen Su Hong
Published: March 2024

Background Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, rendering them more susceptible to the infiltration of pathogenic factors. LJC is obtained by modifing Qiyuan Paste, a traditional Chinese medicine formula for nourishing Yin and blood and calming the mind with a long history. Studies have shown that Dendrobium officinale can improve the immune function of sleep deprivation mice. Based on the traditional Chinese medicine (TCM) theory, LJC was prepared by adding Dendrobium officinale to Qiyuan Paste Decoction.
Methods Yin deficiency syndrome indicators such as back temperature and grip strength of mice in each group were measured, and behavioral tests and pentobarbital sodium induced sleep test were performed. Automatic biochemical analyzer, enzyme-linked immunosorbent assay (ELISA) kit and other methods were used to detect blood routine, serum immunoglobulin (IgG, IgA, and IgM), complement (C3, C4, and ACP) and LDH content in spleen, serum hemolysin and delayed hypersensitivity (DTH) levels. The serum levels of γ-aminobutyric acid (GABA) and glutamate (Glu) were detected by high performance liquid chromatography (HPLC). Hematoxylin-eosin (H&E) staining and Nissl staining were used to evaluate the histological changes of hypothalamus tissue. Western blot and immunohistochemistry were used to detect the expression of GABA pathway proteins GABRA1, GAD, GAT1, and GABAT1, and the expression of CD4+ and CD8+ proteins in thymus and spleen tissues.
Results Of note, LJC could prolong the sleep duration, improved the pathological changes of hippocampus, effectively up-regulated GABA content in the brain of mice, and down-regulated Glu content and Glu/GABA ratio, and increased the expression of GABRA1, GAT1, and GAD and decreased GABAT1 expression to improve sleep disorders. Importantly, LJC could improve the damaged thymus and spleen tissues of the model mice, and increase the activities of ACP and LDH in the spleen of the immunocompromised mice. At the same time, serum hemolysin levels, serum immunoglobulin IgG, IgA, and IgM levels increased after LJC administration , manifested as increased CD4+ content, decreased CD8+ content, and enhanced delayed-type hypersensitivity (DTH) response. In addition, LJC significantly increased the levels of complement C3 and C4, increased the number of white blood cells and lymphocytes in blood, and decreased the percentage of neutrophils.
Conclusions LJC can improve the model of immunocompromised mice with insufficient sleep. The mechanism may be to regulate the content of GABA/Glu and the expression levels of GABA metabolism pathway related proteins in the brain of mice, and enhance the specific and non-specific immune functions of mice.
Efficacy and underlying mechanisms of Three-circle Post Standing Qigong on insomnia in college students: a four-arm, double-blind, randomized controlled trial protocol
Authors: Xu Ming-min , Li Nan , Hu Tian-nuo , Zhou Zhengkun , Chen Yue , Huang Xue , Wei Yulong , Guo Yu
Published: March 2024

Background: Insomnia is common in college students, but its impact on health and wellbeing is often neglected. Enhancing sleep quality through targeted interventions could improve overall health and reduce the risk of consequent co-morbidities and mental health problems. Qigong exercises have been shown to significantly improve sleep quality and relieve insomnia. Three-circle Post Standing (TCPS) can help integrate body, breath, and mind, a fundamental principle of Qigong that promotes holistic wellbeing. In this clinical trial, we aim to (1) evaluate the feasibility, safety, and therapeutic efficacy of administering TCPS to improve sleep quality and quality of life in college students with insomnia; (2) explore the neurophysiological mechanisms underlying the mind adjustments mediated by TCPS in insomnia; (3) investigate body and breath pathophysiology mediated by TCPS in insomnia; and (4) assess the long-term efficacy of TCPS in terms of sleep quality and quality of life.
Methods: This will be a prospective, parallel, four-arm, double-blind randomized controlled trial to investigate the effects and underlying mechanisms of TCPS on college students with insomnia. One hundred college students meeting diagnostic criteria for insomnia will be randomly assigned to receive either 14 weeks of standardized TCPS training (two weeks of centralized training followed by 12 weeks of supervised training) or sham-control Post Standingtraining. Efficacy outcomes including sleep quality, quality of life, neurophysiological assessments, plantar pressure, biomechanical balance, and physical measures will be collected at baseline, eight weeks (mid-point of supervised training), and 14 weeks (end of supervised training). Sleep quality and quality of life will also be evaluated during the four- and eight-week follow-up.
Discussion: This trial will be an important milestone in the development of new therapeutic approaches for insomnia and should be easily implementable by college students with insomnia. The neuro- and pathophysiological assessments will provide new insights into the mechanisms underlying TCPS.
Clinical trial registration: This trial has been registered in the China Clinical Trials Registry (registration number: ChiCTR2400080763).
Safflower Yellow Alleviates Cognitive Impairment in Mice by Modulating Cholinergic System Function, Oxidative Stress, and CREB/BDNF/TrkB Signaling Pathway
Authors: qi yanqiang , wang yanyou , he yingxi , li le , hu yanli
Published: March 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily develops in old age. The main clinical symptom of the disease is memory loss. Therefore, the treatment of learning and memory dysfunction is an important research direction for prevention and treatment of AD. Studies have shown that scopolamine hydrobromide (SCOP), sodium nitrite (NaNO2) and ethanol impair memory acquisition, memory consolidation and memory retrieval in mice, respectively. Safflower yellow (SY) can effectively improve the memory function of AD mice, but the specific mechanism needs further exploration. In the present study, mice were injected with SCOP, NaNO2 and 40% ethanol to establish models of memory acquisition, memory consolidation and memory retrieval impairment. This study investigated the mechanism of SY treatment of AD from the perspectives of oxidative stress, the cholinergic system, the CREB/BDNF/TrkB signaling pathway and synaptic protein expression. We conducted several studies that have shown that after SY treatment, the memory ability of three memory impairment mice models improved, the pathological changes in brain tissue were reduced, the activity of cholinergic system-related enzymes were changed, the level of oxidative stress in the brain of mice was reduced, and the CREB/BDNF/TrkB pathway was activated. In addition, SY can also upregulate the expression of synapse-associated proteins and exert neuroprotective effects.