bluuebunny/crossref_metadata_2025 huggingface dataset:
The Non-uniform Distribution of Horizontal and Vertical Crystalline Lens Rise Using Optical Coherence Tomography
Authors: Fan Limin , Chang Zheng , Xu Yangtao , Yin Xinkai , Wang Zheng
Published: May 2023

Purpose:

To observe the crystalline lens rise (CLR) in horizontal and vertical orientations using anterior segment optical coherence tomography (AS-OCT).

Methods:

Non-invasive swept-source AS-OCT was used to measure the lens thickness, CLR, and angle-to-angle distance (ATA) in both the horizontal and vertical orientations. Anterior chamber depth (ACD) and horizontal white-to-white corneal diameter were obtained using the Pentacam HR (Oculus Optikgeräte GmbH). Axial length was obtained using the IOLMaster 700 (Carl Zeiss Meditec AG). The paired
t
test was used to analyze the difference in CLR between the two orientations. Pearson correlation analysis was performed to investigate the correlations between CLR and other ocular variables.

Results:

This prospective observational study comprised 99 eyes (99 patients) that underwent Visian Implantable Collamer Lens (STAAR Surgical) implantation for myopic correction. The mean CLR was 64.29 ± 168.04 and 208.09 ± 173.12 µm in the horizontal and vertical orientations, respectively. The vertical CLR (VCLR) was significantly greater than the horizontal CLR (HCLR) (
P
< .05). Both the HCLR and VCLR were positively correlated with lens thickness and negatively correlated with ACD (all
P
< .05). The difference in CLR (VCLR-HCLR) was positively correlated with the axial length and the difference in ATA between the two orientations (
P
< .05).

Conclusions:

VCLR was greater than HCLR in most patients with myopia, especially in the longer eyes. This nonuniform distribution in CLR implied different placements of the iridocorneal angles in the horizontal and vertical orientations and should be considered for the selection of ICL size and placement position.

[
J Refract Surg
. 2023;39(5):354–359.]
An application of Pascal distribution involving Kamali type related to leaf like domain
Authors: Saritha K. , Thilagavathi K.
Published: May 2023

This paper aims to study the Geometric properties of analytic function in the open unit disk. In the present investigation, we obtain some geometric properties of Pascal distribution involving Kamali type related to leaf like domain. In this paper, we find coefficient inequality, Radii Properties, convolution product, partial sum of the class $ \Sigma(\delta, \Phi, \beta, s, t, m) $. Furthermore, we examine the distortion bounds belonging to the same class.
Influence of a Distributed Learning Environment on Learners’ Performance
Authors: Wang Daoxin , Jing Zhongyong , Qin Leyang
Published: May 2023

Online high-quality teaching and learning behaviors can take place anytime and anywhere, which comprehensively breaks through isolation of physical space. Individual learning in distributed learning environment is an activity that is transformed from process of individual self-cognition to social cognition of the group. It attaches great importance to interactive behaviors in learning. By strengthening cooperative learning, learning motivation can be further stimulated and learning performance can be improved. A questionnaire about the influence of distributed learning environment on learners’ learning performance was designed. Influence of four components of distributed learning environment interaction on learners’ learning performance was measured, and the mediating effect of collaborative learning on the interaction between learners’ learning performance and distributed learning environment was analyzed. Results show systematic management support of self-knowledge, support of learners’ expression and support of self-reflection can significantly improve learning performance of learners. Collaborative learning plays a full mediating effect in the interaction between distributed learning environment and learning performance of learners. Grade is significant at 0.01 level for learning performance. Conclusions are of great significance to promote occurrence of effective learning behaviors in interactive process of collaborative learning from the perspective of distributed learning environment.
The Effect of Cognitive Modeling in Mathematics Achievement and Creative Intelligence for High School Students
Authors: Ban Hassan Majeed  , Areej Khuder Hassan  , Sabah Saeed Hammadi
Published: May 2023

To identify the impact of the cognitive modeling in mathematics achievement, creative intelligence for secondary school students during the 2022/2023 academic year. To achieve the aim of research, the researchers adopted the experimental research method with two groups (experimental; control) with a post-test. Community of research was identified, which represented by the students of second intermediate grade /first KED. (70) male students were intentionally chosen as a sample study, and they were divided into two groups: an experimental who were taught according to the cognitive modeling, and the other was a control group who were studied according to the usual method. Equivalence was made between the two groups in chronological age, level of intelligence, and previous achievement in mathematics. For the purpose of collecting data for the experiment, an achievement test was built in its final form (20) and also the creative intelligence test out of (25) of test paragraph from thematic type for both of them. Appropriate statistical analyzes were carried out, besides done making sure of the psychometric properties for the two tests. Based on the findings, students of experimental group who studied according to cognitive modeling excelled over those who studied by the traditional.
Quality Evaluation of Innovation and Entrepreneurship Education Based on Modelling of Students’ Behavior Sequences
Authors: Niu Mingzhe
Published: May 2023

In the Innovation and Entrepreneurship (I&E) education of some higher vocational colleges, there’s a common problem: serious disconnection between professional education and practical education, which may result in poor quality of I&E education. With the help of I&E education quality evaluation, we can figure out the distribution and utilization of education resources, discover and solve problems during the teaching process in time, and optimize and adjust teaching content and methods in a targeted manner. Student behavior analysis can reveal the actual needs and questions encountered by students during I&E education, thereby attaining more pertinent and pragmatic evaluation results. For this reason, this paper aims to study the I&E education quality evaluation by means of modelling students’ behavior sequences. At first, a student I&E behavior sequence feature extraction module was created based on attention mechanism, and the student I&E ability level feature extraction layer and student I&E ability level feature evolution layer contained in the module structure were introduced in detail. Then, the data sources of I&E education quality evaluation based on students’ I&E behavior analysis were given, the I&E behavior sequences of students were modeled based on the single-sequence first-order linear differential equation model GM(1,1), and the established model was applied to I&E education quality evaluation. At last, experimental results verified the validity and accuracy of the proposed method.
Chatbot Positive Design to Facilitate Referencing Skills and Improve Digital Well-Being
Authors: Zaky Yara Ahmed Mohebeldin
Published: May 2023

This article examines the effectiveness of a positive-design chatbot in a mobile learning environment on students’ referencing‏ skills and digital well-being in a research context. The sample consisted of 150 postgraduate students at King Faisal University Education College who were writing their master’s dissertations and facing challenges regarding the preparation‏ of American Psychological Association 7th (APA7) edition-style scientific references. this search used a quasi-experimental study involving an achievement pretest and posttest together with a digital well-being scale to gather data and adopted a positive-design for a chatbot to be used in a mobile learning environment. We developed a chatbot mobile app called Smart Assistant for Research Referencing according to the proposed model and assessed its effect on skill development and digital well-being. The results showed that posttest knowledge increased  significantly, and levels of digital well-being also improved. This study provides a model to help postgraduate students and researchers who use the APA7 style to prepare references faster, more easily, and with high accuracy. Where the researches results indicated that there is a problem in students' lack of APA reference skills and their frequent feelings of failure, frustration, anxiety and lack of motivation, the results of this research may help bridge the gap. Instructional designers may benefit from the proposed positive design model when designing positive learning environments based on artificial intelligence (AI). artificial intelligence to improve digital well-being.
A QR Code Used for Personal Information Based On Multi-Layer Encryption System
Authors: Haroon Rashid Hammood Al Dallal  , Wijdan Noaman Marzoog Al Mukhtar
Published: May 2023

Protecting and concealing sensitive data in the modern world is challenging. Due to insufficient protection and privacy, it is feasible for critical information to be fabricated. This led to a significant financial loss for someone. The intended recipient must be trusted with sensitive information and be able to independently authenticate the accuracy of the information by independently checking the specifics. There are several driving the rise in QR codes used for information transmission. Due to their enormous capacity for storing information, QR codes are vital for dissemination. However, most currently deployed QR code solutions employ insecure data formats and never employ encryption. Secure QR Code is data protection and data concealing available technology. The Quick Response (QR) code is widely used and accessible without extensive technical training. Now, the user data stored in a QR code is effectively public knowledge and occasionally even illegally used. To address the abovementioned issues, this study's authors propose a novel QR code encryption system. Using the image's mathematical processing method, we may apply the equivalence class principle to the ordered equations of the two-dimensional code, producing the desired cryptographic result. This method exploits the unique visual properties of the QR code. Only a QR code reader can decode the code's useful information, which is too complex for standard reading methods. It will be utilised to address issues in speedy business client data protection Security, commodity anticounterfeiting, and bicycle sharing QR codes.
A Metaphysics of Dehumanization
Authors: Killmister Suzy
Published: May 2023

Most contemporary accounts of dehumanization construe it either as a psychological phenomenon of seeing the other as non-human, or as as an interpersonal phenomenon of failing to treat the other as they are entitled qua moral agent. In this paper I offer an alternative way of thinking about dehumanization. Drawing on recent work in social metaphysics, I argue that we can productively think of the human as a social kind, and correspondingly of dehumanization as a process of excommunication from that social kind. Such an approach, I show, is better equipped to explain the variety of phenomenon that constitute dehumanization, and the range of processes through which dehumanization can occur.
Una nueva lista de palabras de la lengua mochica del siglo XIX
Authors: Urban Matthias
Published: May 2023

En el presente artículo se da a conocer una lista de 125 palabras de la lengua mochica, redactada en el año 1865 por iniciativa de Santiago C. Montjoy, entonces cónsul de los Estados Unidos en Lambayeque. La lista fue descubierta en los años setenta del siglo pasado por el arqueólogo James B. Richardson III entre la correspondencia diplomática de los cónsules estadounidenses en Lambayeque, archivada en los National Archives (Archivos Nacionales) de los Estados Unidos. La elaboración de la lista responde a una convocatoria de la American Ethnological Society (Sociedad Americana Etnológica) que pidió, en su primera circular del año 1863, que se envíen los equivalentes de 180 palabras inglesas en lenguas indígenas del continente americano. También se discute las circunstancias de la elaboración de la lista y se presenta una transcripción de su contenido y materiales asociados. Además, se ofrece una comparación de las palabras con la representación de las mismas en otras fuentes y un análisis filológico de aspectos seleccionados del material. La lista, a pesar de la ortografía asistemática que se suele encontrar en fuentes de este tipo, ofrece nuevas pistas interpretativas acerca del fonetismo y la fonología del mochica del siglo XIX y se presenta como un recurso que contribuye a profundizar el conocimiento de la lengua.
Role of Gasdermin E in the Biogenesis of Apoptotic Cell–Derived Exosomes
Authors: Hur Jaehark , Kim Yeon Ji , Choi Da Ae , Kang Dae Wook , Kim Jaeyoung , Yoo Hyo Soon , Shahriyar Sk Abrar , Mustajab Tamanna , Kim Junho , Han Kyu Ri , Han Yujin , Lee Sorim , Song Dajung , Kwamboka Moriasi Sheba , Kim Dong Young , Chwae Yong-Joon
Published: May 2023

The gasdermins are a family of pore-forming proteins that has recently been suggested to play a central role in pyroptosis. In this study, we describe the novel roles of gasdermins in the biogenesis of apoptotic cell–derived exosomes. In apoptotic human HeLa and HEK293 cells, GSDMA, GSDMC, GSDMD, and GSDME increased the release of apoptotic exosomes. GSDMB and DFNB59, in contrast, negatively affected the release of apoptotic exosomes. GSDME at its full-length and cleaved forms was localized in the exosomes and exosomal membrane. Full-length and cleaved forms of GSDME are suggested to increase Ca2+ influx to the cytosol through endosomal pores and thus increase the biogenesis of apoptotic exosomes. In addition, the GSDME-mediated biogenesis of apoptotic exosomes depended on the ESCRT-III complex and endosomal recruitment of Ca2+-dependent proteins, that is, annexins A2 and A7, the PEF domain family proteins sorcin and grancalcin, and the Bro1 domain protein HD-PTP. Therefore, we propose that the biogenesis of apoptotic exosomes begins when gasdermin-mediated endosomal pores increase cytosolic Ca2+, continues through the recruitment of annexin-sorcin/grancalcin-HD-PTP, and is completed when the ESCRT-III complex synthesizes intraluminal vesicles in the multivesicular bodies of dying cells. Finally, we found that GSDME-bearing tumors released apoptotic exosomes to induce inflammatory responses in the in vivo mouse 4T1 orthotropic model of BALB/c breast cancer. The data indicate that the switch from apoptosis to pyroptosis could drive the transfer of mass signals to nearby or distant living cells and tissues by way of extracellular vesicles, and that gasdermins play critical roles in that process.
Classification of $p$-groups via their $2$-nilpotent multipliers
Authors: Niroomand Peymam , Parvizi Mohsen
Published: May 2023

For a

p

-group of order

p^n

, it is known that the order of

2

-nilpotent multiplier is equal to

\lvert\mathcal{M}^{(2)}(G)\rvert=p^{\frac12n(n-1)(n-2)+3-s_2(G)}

, for an integer

s_2(G)

. In this article, we characterize all non-abelian

p

-groups satisfying

s_2(G)\in\{1,2,3\}

.
Protective effect of maternal exposure to α-lipoic acid during pregnancy and lactation on susceptibility to OVAinduced neonatal asthma
Authors: Jiang Yong , Liao Xingjuan , Wang Shengsheng , Ni Zhifu , Liang Rui , Zhang Yuling , Tao Didi
Published: May 2023

Purpose: To investigate the beneficial effect of alpha-lipoic acid (ALA) during pregnancy and lactation on susceptibility to ovalbumin (OVA)-induced neonatal asthma, and the mechanism of involved.Methods: Pregnant BALB/c mice were administered ALA (1 % mixed with mouse chow) or standard mouse chow from 6th day of gestation to 21st day of lactation (postnatal). The offspring (neonatal pups) from the OVA and ALA+OVA groups were sensitized on 1st, 7th and 14th postnatal days (PNDs) via intraperitoneal (i.p.) injection of OVA (0.5 μg). Control mice pups were not exposed to OVA. On PND 21, all pubs were again exposed to 1 % OVA aerosol using a nebulizer.Results: Neonatal mice exposed to ALA showed a significant decline (p < 0.05) in the number of inflammatory cells (eosinophils), levels of inflammatory markers (IL-4, IL-13, IL-5 and TNF-α) as well as OVA-specific IgE and total IgE, when compared to neonatal mice from pregnant mice that did not receive ALA (control). Moreover, the antioxidant profiles of ALA-treated mice offspring were significantly improved (p < 0.05). Marked downregulation (p < 0.05) of the protein expressions of NF-κB p-p65 subunit and TNF-α were observed in ALA-treated mice pups.Conclusion: ALA exposure during pregnancy (maternal exposure) markedly decreases OVA-induced asthmatic airway inflammatory response in pups. Thus, ALA might be beneficial for use along with standard anti-asthmatic drugs in the management of pediatric asthmatic patients
Effect of a combination of donepezil tablets and butylphthalide soft capsules on neurological function in dementia patients, and its effect on serum inflammatory factors
Authors: Ma Fuqiang , Chen Tao , Wang Yanqiu , Xu Junxia
Published: May 2023

Purpose: To determine the effect of combined use of donepezil tablets and butylphthalide soft capsules in the treatment of patients with vascular dementia, and its effect on serum inflammatory factor levels and neurological functional recovery of patients.Methods: 120 patients with vascular dementia were selected and assigned to group A (n = 60) and group B (n = 60). All patients were treated with donepezil tablets, while patients in group A were, in addition, treated with butylphthalide soft capsules. Mini mental state examination (MMSE) scores, clinical dementia rating scale (CDRS) scores, activities of daily living (ADL) scores, incidence of adverse reactions, serum inflammatory factor levels and neurological functional recovery were determined.Results: There was significantly higher MMSE score in group A than in B, while CDRS score was lower in group A. The ADL scores and inflammatory factor levels were lower in group A than in B (p < 0.001), while neurological functional recovery was markedly better in A (p < 0.001). Incidents of unwanted events were comparable in groups A and B, and there were no serious complications in the patients.Conclusion: The combination therapy of donepezil tablets and butylphthalide soft capsules reduces inflammatory factor levels and improved cognitive level and quality of life of patients with vascular dementia. It also produces good neurological functional recovery and low incidence of adverse reactions. Therefore, this treatment strategy has potentials for the management of vascular dementia.
Mitigating effect of clopidogrel and systematic management on adverse events after interventional therapy for coronary heart disease
Authors: Shao Jing , Chen Wenqiang
Published: May 2023

Purpose: To investigate the efficacy of clopidogrel combined with systemic management care in the prevention of adverse events in patients with coronary heart disease after interventional therapy.Methods: 100 patients undergoing interventional therapy after coronary heart disease admitted to Jinan Third People’s Hospital from April 2018 to April 2020 were assigned at a ratio of 1:1 either into control (low-molecular-weight heparin (LMWH) injection) or study groups randomly (clopidogrel plus system management care). Thrombin time, prothrombin time, fibrinogen, incidence of adverse events, NIHSS score and QLI score were determined for the two groups.Results: There thrombin time, prothrombin time and fibrinogen in the two groups were similar (p >0.05). The study group showed a significantly lower incidence of adverse events than the control group (p < 0.05). The treatment administered to the study group resulted in a higher QLI (quality of life) scores than those in the control group (p < 0.05). Remarkably lower National Institutes of Health Stroke Scale (NIHSS) score was reported in the study group versus control group (p < 0.05).Conclusion: Clopidogrel plus systemic management care might be a preferable therapeutic strategy for patients with coronary heart disease undergoing interventional therapy. It reduces the incidence of adverse events, significantly improves the quality of life of patients, and enhances neurological function. Thus, this therapeutic strategy has significant promise in the management of coronary heart disease.
Effect of the combination of percutaneous transluminal angioplasty and pharmacological thrombolysis on hemodialysis patients
Authors: Yang Liwen , Tang Fengying , Zhong Weiqiang
Published: May 2023

Purpose: To examine the efficacy of percutaneous transluminal angioplasty (PTA), combined withpharmacologic thrombolysis (PT) on thrombosis of autologous arteriovenous fistulas (AVFs),inflammatory factors, and β2 microglobulin (β2-MG) levels in hemodialysis patients.Methods: Seventy-eight patients with AVF thrombosis allocated randomly into a control group (CG) received PTA, and a study group (SG) received PTA combined with PT (n = 39 in each). The patency, vascular condition, inflammatory factors, viz, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP)), β2-MG levels, vascular-related factors (VEGF-A and MCP-1), complications, and quality of life were determined.Results: At three and six months after surgery, t SG exhibited a higher vascular patency than CG (p <0.05). Serum levels of IL-6, hs-CRP, β2-MG, VEGF-A, and MCP-1 of t SG were lower than those of CG(p < 0.05). The SG showed higher cross-sectional area, inner diameter at the site of fistula, and better quality of life scores than CG (p < 0.05).Conclusion: The combination of PTA and PT enhances efficacy, increases vascular patency, reduces inflammatory response, lowers the level of β2-MG, and improves quality of life in patients with AVFs without increasing complications. Thus, the combination treatment has potentials for the management of hemodialysis patients.
Eriocitrin alleviates sevoflurane-induced cytotoxicity in HT22 cells via Nrf2 pathway
Authors: Yuan Zhiguo , Zhu Mei , Wei Xiaojia , Li Xiaojing
Published: May 2023

Purpose: To investigate the effect of eriocitrin on sevoflurane-induced neurotoxicity in mice.Methods: Mouse hippocampal neurons (HT22) were exposed to different concentrations of sevoflurane for 6 h and then incubated with different concentrations of eriocitrin for another 24 h. Cell viability was determined by CCK8 assay, while fluorescence intensity of dichlorodihydrofluorescein was used to evaluate reactive oxygen species. Enzyme linked immunosorbent assay (ELISA) was used to determine oxidative stress, and cellular apoptosis was determined by flow cytometry.Results: Sevoflurane exposure decreased HT22 cell viability, whereas incubation with eriocitrin increased viability of sevoflurane-treated HT22 cells (p < 0.05). Sevoflurane-induced increase in dichlorodihydrofluorescein fluorescence intensity was reduced by eriocitrin, but eriocitrin attenuated sevoflurane-induced increase in malondialdehyde, superoxide dismutase, and glutathione peroxidase in HT22 cells. Cell apoptosis increased after sevoflurane exposure, and eriocitrin suppressed apoptosis in sevoflurane-treated HT22 cells through downregulation of cleaved caspase-3 and cleaved caspase-9 (p< 0.05). Eriocitrin incubation enhanced protein expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1) in sevoflurane-treated HT22 cells (p < 0.05).Conclusion: Eriocitrin ameliorates sevoflurane-induced oxidative stress and inflammatory response in HT22 cells via activation of Nrf2/HO-1/NQO1 signaling. Thus, agent may be useful in the treatment of sevoflurane-induced toxicity, but in vivo studies are required to buttress this.
Effect of Jinlida granule on glycolipid metabolism, oxidative stress, and inflammatory factors in type 2 diabetes mellitus patients with non alcoholic fatty liver disease
Authors: Cai Jing , Xia Xue , Qiao Jingmin , Gao Ying , Li Hongyan , Liu Yiran
Published: May 2023

Purpose: To investigate the effect of Jinlida granule on glycolipid metabolism, oxidative stress, and inflammatory factors in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). Methods: A total of 132 T2DM patients with NAFLD were equally and randomly divided into study and control groups. Patients in the control group were treated with non-drug therapy including routine diet control, exercise, alcohol avoidance, and drug therapy (using blood glucose and lipid lowering drugs). The study group was treated with Jinlida granule in addition to other measures used in the control group. Blood glucose, blood lipid, and liver function parameters were compared after treatment. Nesfatin-1, oxidative stress, inflammatory factors, liver fat content, and degree of fibrosis were assessed. The efficacy and potential mechanism of Jinlida granule in the patients were assessed. Results: Blood glucose, lipid, and liver function parameters in the study group were lower than in the control group following treatment. Nesfatin-1, GSH-Px, and adiponectin levels were higher, while MDA, TNF-α, liver fat, LSM and CAP levels were lower than in the control group (p < 0.05). The response rate of the study group was 96.97 %, which was higher than the 87.88 % in the control group (p < 0.05). The incidence of adverse drug reactions in the two groups during treatment was comparable (p > 0.05). Conclusion: Jinlida granule exerts positive effect on T2DM patients with NAFLD. Thus, Jinlida granule has potentials for application as an adjuvant in the treatment of T2DM with NAFLD.
Effect of different laser energy settings on the formation of opaque bubble layer and visual performance in SMILE surgery: a single center clinical study
Authors: Li Jing , Wang Xiaoyi , Deng Ruidong , Shi Lei , Zhang Yiting , Chen Zilin
Published: May 2023

Purpose: To investigate the effect of different laser energy settings, including varying combinations of energy and spot distance setting, on the formation of opaque bubble layers in the first stage of preoperative and postoperative visual quality in patients with myopia and astigmatism. Methods: A total of 72 patients were enrolled in this study. They all had myopia and/or astigmatism and had undergone small incision lenticule extraction (SMILE) in both eyes between April 2021 and February 2022 at Huizhou Municipal Central Hospital, Huizhou, China. They were randomly assigned to four groups of 18 patients each. The energy parameters were set in the four groups, with a pulse energy of 120 or 130 nJ and spot distance of 3.0 μm or 4.5 μm. The indices assessed included formation of opaque bubble layer in the first stage after surgery, uncorrected distance visual acuity (UCVA), higher-order aberrations (HOAs), and visual sensitivity under different light levels at 3 months postoperatively. Results: Total HOAs at 3 months were smaller, and contrast sensitivity at various luminance levels under specific spatial frequencies was better when the laser energy was set to 120 nJ and the spot distance was set to 4.5 μm when compared with the laser energy set at 130 nJ and spot distance set at 3.0 μm, respectively (p < 0.05). Conclusion: Lower energy and larger spot spacing laser settings produce better visual outcomes for patients, and also affect the formation of a first-stage opaque bubble layer, which is a useful laser for clinical ophthalmologists during SMILE surgery. The energy setting provides a reliable basis to achieve better visual outcomes for patients after surgery.
A meta analysis of key risk factors for sudden unexpected death in epilepsy
Authors: Liu Yanjun , Huang Yajin
Published: May 2023

Purpose: To examine the risk factors (RFs), associated with Sudden Unexpected Death in Epilepsy (SUDEP), and the quantitative standards required to measure them Methods: The literature on RFs associated with SUDEP was systematically reviewed up to August 2020 in databases, including PubMed, the Cochrane Database and Embase. Revised Newcastle-Ottawa Scale (NOS) was performed to determine the quality of each study in this meta-analysis (MA), with a score of ≥ 3, indicating good quality. Any controversies in data extraction and quality assessment were resolved through counsel or adjudication with a third researcher. Results: An initial screening of the literature following the search strategy and manual inclusion yielded a total of 767 studies. After excluding duplicates as well as articles that did not match the topic, 112 studies remained. Twenty-nine studies were finally selected based on the inclusion and exclusion criteria. After a careful review of the full text, nine studies were included in the MA. Conclusion: The five RFs for SUDEP included age at the onset of epilepsy ≤15 years, generalized-tonic-clonic seizure, seizure frequency ≥50 seizures/year, treatment with a combination of multiple antiepileptic drugs, and history of alcohol abuse.
Comparative efficacy of triple combination therapies containing either bortezomib or rituximab in treatment naïve patients with lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia
Authors: Shang Jingjing , Shi Xiaolan , Yan Lingzhi , Jin Song , Yao Yin , Wang Jing , Yao Weiqin , Yan Zhi , Wu Depei , Fu Chengcheng
Published: May 2023

Purpose: To evaluate the comparative efficacy of triple combination therapies of cyclophosphamide/dexamethasone containing either bortezomib or rituximab in treatment-naïve patients diagnosed with lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia, LPL/WM). Methods: Symptomatic, untreated patients with LPL/WM diagnosed in the First Affiliated Hospital of Soochow University were enrolled in this study and divided into two groups (BCD and RCD). Group BCD consisted of 16 patients administered bortezomib/cyclophosphamide/dexamethasone, while group RCD (15 patients) received rituximab/cyclophosphamide/dexamethasone. The efficacy of the two therapies and the Kaplan-Meier survival curve of the groups were evaluated. Results: With regard to overall response rate (ORR) and minimal response rate (MRR), there was no statistically significant difference between the 2 groups (100 vs 86.6 %, p = 0.226, and 81.25 vs 60.0 %, p = 0.252, respectively). The median time to minimal response (MR) in the BCD group was 1.3 months, which was shorter compared with that of RCD group (3.5 months, p = 0.026). Treatment-related toxicities (grade>2) were leukopenia, neutropenia, hypohepatia and pneumonia. With a median study follow-up of 27 months, disease in 18 patients (8 vs 10) progressed while 4 patients died (all in RCD group). The estimated median progression free survival (PFS) was 43 and 35 months in groups BCD and RCD, respectively, but the overall survival (OS) rate in 25 months significantly differed between the 2 groups (100 % vs 66.1 %，p = 0.033). Conclusion: The two regimens are active, produced responses and are safe as primary therapies for patients with LPL/WM. However, the response median time was much shorter in group BCD patients, and thus might have better survival benefits.
Prognostic value of serum stimulating thyroglobulin in metastatic radioactive iodine refractory differentiated thyroid cancer
Authors: You Shuchun , Zha Jinshun , Xie Long , Jiang Tingyin
Published: May 2023

Purpose: To investigate the prognostic value of serum-stimulated thyroglobulin (ps-Tg) before the first 131I therapy in patients with metastatic radioactive iodine-refractory differentiated thyroid cancer (RR-DTC). Methods: From August 2017 to August 2020, the clinical data for 160 patients with thyroid papillary carcinoma (PTC) who received thyroidectomy and 131I treatment were analyzed retrospectively. Differences in clinical data and related thyroid indices were compared. Univariate and multivariate logistic regression analyses were used to analyze the related factors affecting the occurrence of RR-DTC. Receiver-operator characteristic (ROC) curves were used to determine the discriminative power of ps-Tg in predicting RR-DTC, while the Kaplan-Meier survival curve of ps-Tg for RR-DTC was drawn. Results: A total of 160 patients with thyroid cancer were enrolled, including 47 males, and 113 females (70.62 %). Overall mean age was 39 ± 13 years old. The follow-up results showed that 68 patients with thyroid cancer were refractory to radioactive iodine. The ps-Tg of the iodine-refractory group was higher than that of the iodine-receptive group (p < 0.001). Multivariate logistic regression showed that ps-Tg was an independent risk factor for RR-DTC (OR = 1.086, p = 0.000). The optimal cut-off value of ps-Tg for predicting progression to RR-DTC was 19.21 μg/L. Kaplan-Meier survival curve showed that the risk of iodine refractory in patients with thyroid cancer (≥ 19.21 μg/L) was higher than that of patients with thyroid cancer < 19.21 μg/L (p < 0.001). Conclusion: The ps-Tg before the first 131I therapy independently predicts the occurrence of metastatic RR-DTC when ps-Tg is greater than the risk of RR-DTC increase. This finding will be helpful in predicting the occurrence of RR-DTC, in order to determine the best time to start treatment and make individualized treatment decisions.
Leonurine inhibits breast cancer cell growth and angiogenesis via PI3K/AKT/mTOR pathway
Authors: Tian Junjun , Peng Lizhong , Wang Dongjie
Published: May 2023

Purpose: To elucidate the effect of leonurine on the proliferation, invasion, migration, and angiogenetic potential of breast cancer cells. Methods: Human breast cancer cell line (MDA-MB-231) and normal breast cell line, (SK-BR-3) were cultured. Both cell lines were treated with 200, 400, or 800 μM leonurine and cultured for 0 (control), 24, 48, or 72 h. Cell counting kit-8 (CCK8) and colony formation assays were performed to measure cell viability and proliferation. Invasion and migration were evaluated using in vitro invasion and wound healing assays, respectively, while angiogenesis was evaluated by the formation of branching point structures. Furthermore, phosphorylation of PI3K, AKT, and mTOR were assessed by Western blot. Cell viability, invasion, migration, and angiogenesis were further investigated in media including 740Y-P, 800 μM leonurine, and 800 μM leonurine plus 740Y-P. Results: Leonurine inhibited the proliferation of breast cancer cells and weakened breast cancer cell invasion, migration, and angiogenetic potential in a dose-dependent manner (p < 0.05). Furthermore, leonurine repressed PI3K/AKT/mTOR pathway by reducing the phosphorylation of PI3K, AKT, and mTOR. Leonurine also inhibited breast cancer progression (p < 0.05). Conclusion: Leonurine inhibits breast cancer progression by inhibiting PI3K/AKT/mTOR pathway, and is thus, a potential agent for the management of breast cancer.
An exploration into the effects of prolonged sitting on cardiovascular health and the influence of modifiable lifestyle factors.
Authors:   , Paterson Craig
Published: May 2023

Time spent in sedentary behaviours, particularly prolonged sitting, has been identified as an independent risk factor for cardiovascular disease (CVD). However, the physiological mechanisms by which prolonged sitting contributes to CVD burden and what can be done to offset that burden remains unclear. Whilst a working model currently exists, further work is needed. In order to progress the working model, it is first necessary to consolidate the existing literature to identify the likely effect of prolonged sitting on the cardiovascular system. Identifying the impact of prolonged sitting is complicated by the fact that this behaviour is likely to cluster with other modifiable lifestyle behaviours, the most prominent of which are fat consumption, habitual physical activity, and cardiorespiratory fitness. Understanding into how these modifiable lifestyle factors may impact the cardiovascular system in conjunction with prolonged sitting is vital for the development of a robust biologically plausible model. As such, this thesis has two overarching aims: 1) to consolidate the existing evidence related to prolonged sitting, with and without interruption, and certain markers of cardiovascular health and function using systematic review and meta-analytic practices, and 2) to conduct experimental studies to investigate the interactions of prominent modifiable lifestyle factors on cardiovascular responses to bouts of prolonged sitting. This thesis demonstrated that: 1) acute bouts of prolonged uninterrupted sitting negatively impact cardiovascular function, but regularly interrupting bouts of prolonged sitting, particularly with aerobic activities, may offset these negative effects, and, 2) whilst cardiorespiratory fitness and habitual physical activity do not impact the cardiovascular responses to an acute sitting bout, the combined deleterious effects of prolonged sitting and consumption of a high-fat meal can be offset using regular interruptions. Collectively, this thesis identified a robust mechanism by which prolonged sitting contributes to cardiovascular burden, and further, this thesis offers insight into strategies to mitigate cardiovascular dysfunction. Finally, this thesis identified several methodological practices within the research area which should be improved.
Mathematics of stable tensegrity structures
Authors: Harish Ajay B. , Nandurdikar Vijay , Deshpande Shubham , Andress Stephanie
Published: May 2023

Tensegrity structures have been extensively studied over the last years due
to their potential applications in modern engineering like metamaterials,
deployable structures, planetary lander modules, etc. Many of the form-finding
methods proposed continue to produce structures with one or more soft/swinging
modes. These modes have been vividly highlighted and outlined as the grounds
for these structures to be unsuitable as engineering structures. This work
proposes a relationship between the number of rods and strings to satisfy the
full-rank convexity criterion as a part of the form-finding process. Using the
proposed form-finding process for the famous three-rod tensegrity, the work
proposes an alternative three-rod ten-string that is stable. The work
demonstrates that the stable tensegrities suitable for engineering are feasible
and can be designed.
From the exhibition in colonial exhibitions to the new Ainu National Museum: Is the voice of the indigenous impenetrable in the museum space?
Authors: Berthon Alice
Published: May 2023

Has the inauguration of the first Ainu National Museum in Japan in 2020, which follows the recognition of their indigenous status in 2019, redefined the actors at play in discussing Ainu history? The study of this new museum will serve as a case study to analyse the elaboration of discourses defining Self and Other, as well as the relationship between those who produce knowledge about the Ainu and the Ainu themselves.

L’inauguration en 2020 au Japon du premier Musée national aïnou, qui fait suite à la reconnaissance officielle de leur autochtonie en 2019, a-t-il rebattu les cartes de ceux qui ont voix au chapitre ? L’étude de ce nouveau musée sera l’occasion de revenir sur la construction des discours portés sur l’Autre et sur Soi et les rapports entretenus entre les producteurs de savoir et les personnes sur qui portaient et qui portent aujourd’hui ce savoir.
“Here come the anthropos”: what is an archeologist for ?
Authors: Whittaker John , Darmangeat Christophe
Published: May 2023

Pour une publication sur Épisciences.

Whittaker John, 1997, “Here Come the Anthros. What Good is an Archaeologist?” in Andelson Jon (dir.), Anthropology Matters: Essays in Honor of Ralph A. Luebben, Grinnell College, Grinnell, p. 101-108.

Starting with a song denouncing anthropologists and prehistorians as disrespectful of the cultures they study, the article reflects on the relationship between lost cultures and their scientific study, drawing on the author’s personal experience. It then examines NAGPRA, the federal “Native American Graves Protection and Repatriation Act”, which in 1990 gave Native American communities extensive rights over various cultural properties and archaeological sites. He highlights the paradoxical, if not perverse, effects of such legislation, which has not necessarily contributed to a better knowledge (and recognition) of pre-colonial societies in North America.

À partir d’une chanson dénonçant les anthropologues et des préhistoriens comme irrespectueux des cultures qu’ils étudient, l’article propose une réflexion sur le rapport entre les cultures disparues et leur étude scientifique inspirée de l’expérience personnelle de l’auteur. Il examine ensuite le NAGPRA, loi fédérale sur « la protection et le rapatriement des tombes des natifs américains » qui, en 1990, a conféré aux communautés amérindiennes des droits étendus sur divers biens culturels et sites archéologiques. Il souligne notamment les effets paradoxaux, sinon pervers, d’un tel dispositif législatif, qui n’a pas forcément contribué à une meilleure connaissance (et reconnaissance) des sociétés précoloniales d’Amérique du Nord.
La Jerusalén celeste, un símbolo recurrente
Authors: Antón Pacheco José Antonio
Published: May 2023

La ciudad de Jerusalén se convierte en una determinación de los símbolos axiales y de construcción. A partir de Isaías 54, 14-17, el símbolo se transforma de tal manera que va desplegando nuevos significados. La literatura apocalíptica es un caso ejemplar. Se puede decir que el símbolo de la Jerusalén celestre o nueva Jerusalén encuentra en Emanuel Swedenborg una presencia que continúa todos sus sentidos.
CORA: A Technique to control Packet Loss in Multicasting AdHoc Networks
Authors: C.Satheesh Pandian  , CMT.Karthikeyan
Published: May 2023

Ad Hoc network changes the location and configures itself. Cooperative Communication leverages the broadcast nature of the wireless channels and achieves the improvement in system capacity and delay. To manage the medium access interactions, an efficient Cooperative Medium Access Control (CMAC) protocol is used to improve the network performance in terms of lifetime and energy efficiency. By utility based relay selection strategy, performance is increased based on location information and residual energy. This strategy helps to select the best cooperative node with better channel condition, best relay and balanced energy consumption. However, the packet loss is not controlled. To overcome this, the proposed system using Collaborative Opportunistic Recovery Algorithm (CORA) which is designed for multicast applications with low packet loss and latency constraints. To recover peer-to-peer packet loss, Cached Packet Distance Vector (CPDV) protocol is used.
A High-Efficient and Low-Cost Localization System for Wireless Sensor Networks
Authors: C.M.T.Karthigeyan  , C.Satheesh Pandian
Published: May 2023

The problem of localization of wireless sensor nodes has long been regarded as very difficult to solve, when considering the realities of real world environments. In this paper, we formally describe, design, implement and evaluate a novel localization system, called Spotlight. Our system uses the spatio-temporal properties of well controlled events in the network (e.g., light), to obtain the locations of sensor nodes. We demonstrate that a high accuracy in localization can be achieved without the aid of expensive hardware on the sensor nodes, as required by other localization systems. We evaluate the performance of our system in deployments of Mica2 and XSM motes. Through performance evaluations of a real system deployed outdoors, we obtain a 20cm localization error. A sensor network, with any number of nodes, deployed in a 2500m2 area, can be localized in under 10 minutes, using a device that costs less than $1000. To the best of our knowledge, this is the first report of a sub-meter localization error, obtained in an outdoor environment, without equipping the wireless sensor nodes with specialized ranging hardware.
Feature Extraction and Classification of Hyperspectral Image using SVM
Authors: C.Satheesh Pandian  , CMT.Karthikeyan
Published: May 2023

Hyperspectral image consists of consecutive number of bands. Partition the number of band in order to visualize the elements present in each band. First Denoising using canny edge detector to detect the edge from the image. Then super pixel segmentation segment the element based on color. In this paper proposed a method for decomposition as Contourlet Transform(CT) is to get contours.CT has Laplacian Pyramid and Directional Filter Bank(DFB) is used. Laplacian Pyramid(LP) decompose the bands into subbands and Directional Filter Bank(DFB) used to access each edges and the elements. Elements present in the image, classified by SVM classification. Thus proposed system make use of contourlet transform for detecting contours. Finally compare the proposed method with other decomposition mechanism for element identification. The experimental results show that the proposed method accesses the element along with contours.
The Impact of Supplier Selection and Monitoring on the Effectiveness of Public Procurement in Ghana: Cost Reduction Point of View
Authors: Emmanuel Ampong Afoakwah  , Hannah Kemevor
Published: May 2023

The aim of this study is to examine the role of supplier selection and monitoring on the effectiveness of public procurement in terms of cost reduction in Ghana. Procurement effectiveness as an element of public performance management can contribute to achieving Value for Money by reducing administrative overhead costs and directing resources to support more complex procurement processes. Procurement adds value by reducing costs, without the compromise of quality, product failures, assuring the operational efficiency to enable better quality without any additional cost with an aim to achieve the best objectives, output at a reduced cost in the supply chain. This study provides procurement practitioners with insights into selecting the proper suppliers and embracing supplier monitoring to achieve procurement efficiency in terms of cost reduction. This study examines the effects of supplier selection and supplier monitoring on procurement cost reduction as a measure of public procurement efficiency in the Ghanaian context. Consequently, it provides empirical evidence of supplier management practices in the public procurement context. A structured questionnaire was used to collect cross-sectional survey data from 170 public procuring entities in Ghana. Structural equation modelling (SEM) was used to analyse the collected data.
High Potential Activity of Garlic on Some Physiological Characteristics of Bacteria: Review
Authors:   Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq., Yaseen Najlaa Nabhan
Published: May 2023

In history, various cultures and civilizations had been applied garlic to prevent infections throughout many centuries. It could be used as raw juice, powders and capsules by means of dietary complements, so it differs from elements of food or conventional foods. It displays antibiotics activities against microorganisms, especially bacterial strains which have become resistant to antibiotics. Therefore, natural origins of antibiotics resemble cheap and effective choice for resistant strains. Because of garlic impressive antimicrobial effectiveness against multiple microbial infections, it is necessary to highlight its role in reduction of some physiological characteristics of bacteria that can cause many infections.