bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting TXNIP for neuroprotection: A novel approach to reducing inflammation and promoting recovery in ischemic stroke
Authors: He Chongxin , Bao Yong , Xu Yong , Cheng Jingjing , Hu Xinxin
Published: December 2024

Ischemic stroke often results in high mortality and significant disability. Current research primarily focuses on understanding neuroinflammation and cell death following a stroke to identify novel therapeutic targets. This study investigates the endothelial cell-specific role of Thioredoxin interacting protein (TXNIP) in ischemic stroke and its underlying molecular mechanisms both in vitro and in vivo. By targeting endothelial cells, we aim to determine how TXNIP knockdown promotes neuroprotection, enhances angiogenesis, and reduces inflammation post-stroke. In vitro, an oxygen-glucose deprivation (OGD) model using bEnd.3 cells simulated ischemic conditions. Cellular injury was evaluated through cell proliferation and angiogenesis assays, while dual immunofluorescence staining assessed ZO-1 and CD31 expression. Western blotting measured protein levels of TXNIP, nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), ASC, pro-caspase-1, and interleukin-1β (IL-1β). In vivo, a middle cerebral artery occlusion (MCAO) mouse model was employed to mimic ischemic stroke. Brain injury was evaluated using triphenyl tetrazolium chloride (TTC) and Nissl staining, and molecular changes in injury markers were assessed via Western blot analysis. In vitro, TXNIP knockdown promoted cell proliferation and angiogenesis, reduced inflammation, and decreased ZO-1 and CD31 fluorescence intensity. TXNIP knockdown also reversed OGD-induced upregulation of TXNIP, NLRP3, ASC, pro-caspase-1, and IL-1β. In vivo, TXNIP knockdown improved neurological recovery, reflected by lower Longa scores, increased Nissl body presence, and reduced infarct size. These findings suggest that TXNIP knockdown mitigates inflammation, enhances angiogenesis, and reduces cerebral damage following ischemic stroke. This provides valuable insights into potential endothelial cell-specific therapeutic strategies for stroke treatment.
Elimination of Cadmium using Silica Gel Prepared from Blast Furnace Slag
Authors: Chouchane Toufik , Abedghars Mohamed Tayeb , Chouchane Sabiha , Boukari Atmane
Published: December 2024

In this work, the silica gel recovered from the blast furnace slag was exploited for the elimination of cadmium in batch mode under the action of different factors. Physico-chemical analyzes revealed that the modified slag is only composed of silica (96.14%). Its specific surface area is 484 m2g–1 and the pH corresponding to point of zero charge is 4.2. Adsorption isotherms demonstrated that the removal of cadmium on modified slag The experiment revealed that at pH 6, the effect of the determining factors contributed to the progression of the sorption capacity, which was measured at 154.11 mg/g and was accomplished on a homogeneous monolayer surface (R2 = 099). Kinetic analysis revealed that this process agreed with the pseudo-second-order kinetic model (R2 ≥ 0.99). In addition, it was indicated that the diffusion of the pollutant is ensured by external and intraparticle diffusion. The values of thermodynamic variables clarified that cadmium sorption is spontaneous, exothermic, less entropic and physically executed under the effect of electrostatic interaction. The desorption process revealed that the reuse of Silica gel was feasible over five consecutive cycles.
Inhibition of Biliverdin Reductase Diminished the Protective Activity of Bilirubin and Biliverdin Against Oxidative Stress-Induced Injury in Human Vascular Endothelium
Authors: Sharma Kuldeepak , Zajc Irena , Albreht Alen , Žiberna Lovro
Published: December 2024

Endothelial dysfunction is an important risk factor for the development of cardiovascular diseases, and its condition is further aggravated by oxidative stress. Biliverdin (BV) and bilirubin (BR) are potent antioxidants that protect endothelial cells, with biliverdin reductase (BVR) converting BV to BR to maintain redox balance. This study explored BVR’s role in mediating these protective effects under normoxic and hypoxia-reoxygenation conditions. Pharmacological inhibition of BVR reduced the protective effects of BV and BR, as evidenced by the decreased cell viability, cellular antioxidant activity, and intracellular bilirubin levels. Activation of ERK1/2 reduced BVR’s protective function, while its inhibition enhanced it. Additionally, disruption of the BVR-ERK interaction further modulated these effects, highlighting BVR-ERK1/2 interaction sites as potential therapeutic targets for oxidative stress-induced endothelial dysfunction.
Preparation, Characterization and Theoretical Calculation of a Cadmium Complex of 3-hydroxy-2-methylquinolin-4- carboxylate and 1,10-phenanthroline
Authors: Qiu Ting-Qun , Lu Zhi-Tao , He Zi-Jian , Xie Zheng-Ping , Guo Jin , Yi Xiu-Guang
Published: December 2024

A novel organic-inorganic hybrid cadmium complex [Cd(MCA)2(Phen)(H2O)] (MCA = anion of 3-hydroxyquinoline-4-carboxylic acid; Phen = 1,10-phenanthroline) was synthesized by solvothermal method and characterized by single crystal X-ray diffraction. The complex exhibits a two-dimensional structure through hydrogen bonding and π···π packing interactions. Solid state photoluminescence specter shows that the complex displays an emission in the red region of the light spectrum that time-dependent density functional theory calculations reveal can be attributed to ligand-to-ligand charge transfer. Solid diffuse reflection specter shows that the energy band gap of the complex is 2.32 eV.
Analytical Solution of the Steady Navier-Stokes Equation for an Incompressible Fluid Entrained by a Rotating Disk of Finite Radius in the Area of Boundary Layer
Authors: Oleh G Shvydkyi
Published: December 2024

The flow in the neighborhood of a rotating disk is of great practical importance, particularly in connection with rotary machines. It becomes turbulent at larger Reynolds numbers, , in the same way as the flow about a plate. In this article, we consider a motion of incompressible fluid that is always turbulent in azimuthal direction (Reynolds number based on azimuthal velocity) and is of both kinds in a radial direction, i.e. laminar (Reynolds number based on radial velocity) and turbulent (). The equations of analyticity of functions of a spatial complex variable (shortly, the equations of tunnel mathematics) afford a possibility to seek the solutions of steady Navier-Stokes equation in view of elementary functions. All vector fields, including those obeying the Navier-Stokes equation, satisfy the equations of tunnel mathematics. The Navier-Stokes equations themselves are afterward applied for verification of obtained solutions and calculation of the pressure. Obtained formulae for pressure allow us to visualize the presence of the boundary layer and estimate its thickness for laminar and turbulent flows. We use Prandtl`s concept of considering fluids with small viscosities, i. e. we suppose that the Reynolds number is enough large and the viscosity has an important effect on the motion of fluid only in a very small region near the disk (boundary layer). We also suppose that the fluid and the disk had at the beginning the same temperatures and the energy dissipation occurs only by means of internal friction.
Lumbar Facet Joint Cysts: Evaluating Clinical Trends and Treatment Outcomes in a Single-Centre Retrospective Case Series
Authors: Ramy Sherif , Jorge Carter , MJH McCarthy
Published: December 2024

Introduction: Lumbar facet joint cysts are a rare but significant cause of back and radicular pain. Their infrequency leaves literature sparse and optimal management debated. This study analyzed the characteristics and treatment outcomes of facet joint cysts in patients within our Health Board, evaluating adherence to current management guidelines and treatment efficacy.
Materials and methods: A retrospective review included 87 patients diagnosed with lumbar facet joint cysts via MRI over 5 years. MRI findings were analyzed for cyst characteristics and associated spinal pathologies, while clinical records were reviewed for symptomatology and treatments received.
Results: Lumbar facet joint cysts were identified in 0.39% (87/22,292) of lumbar spine MRIs. Patients had a mean age of 61.2 years and a male-to-female ratio of 35:52. Cysts most commonly occurred at L4-L5 (50%) and L3-L4 (26.2%), with 62.8% causing neural compromise, predominantly affecting the left L5 nerve root. Symptoms were present in 70.1% of patients, with 43.7% undergoing interventions. Among treated patients, 89.5% received facet joint injections, but only 45.2% experienced short-term relief. Surgical outcomes were universally positive at 6 weeks, although 21.4% required further interventions.
Conclusion: While injections offer limited short-term relief, surgical treatment consistently provides superior outcomes. However, considering the risks of surgery, facet joint injections should remain the first-line approach, reserving surgery for refractory cases. This pragmatic strategy balances symptom control with patient safety, optimizing outcomes for this challenging condition.
Multiplex PCR for Tetracycline Resistance Genes SOP v1
Authors: C. Condon Justine
Published: December 2024

The tetracyclines are the most widely used drugs in food animal production both globally, and in the United States (U.S.).They account for 36% of all drugs sold in the U.S. in 2018 for veterinary purposes, with 44% of those attributed to use in cattle and 48% in swine. Although these drugs are classified as “Highly Important” (the second category) by the World Health Organization (WHO), they are not listed on the Center for Disease Control's (CDC) 2019 Antibiotic Resistance Threats Report. However, they are commonly used to assess antibiotic resistance in soil and water. This protocol describes the correct procedures on how to set-up and run the Tetracycline Gene Multiplex PCR assay.
Masculinidades en las políticas públicas: una necesidad apremiante
Authors:   Universidad del Norte, Martínez Bustamante Clarisa
Published: December 2024

El presente artículo es producto de una investigación cualitativa realizada con gestores de violencia contra la pareja mujer, la cual se desarrolló en Leticia – Amazonas. El estudio buscó evidenciar y comprender la relación entre violencia íntima e identidad masculina, a partir de los imaginarios de los participantes sobre conceptos como violencia, género, masculinidad y feminidad. A partir del análisis de los resultados se evidenció la necesidad de integrar las políticas públicas y el abordaje de las masculinidades como vía indispensable para la superación de las violencias por razones de género. Con este propósito se explora la utilidad de las políticas públicas, así como el concepto de masculinidad hegemónica y su relación con la violencia contra la pareja, a partir de la propuesta de un abordaje humanizado del perpetrador de violencia. Se concluye que las normas de género afectan tanto a hombres como a mujeres y que es necesario tener en cuenta esta relación para gestar verdaderos cambios en materia de inclusión y prevención de las violencias.
Policy‐Maker of Last Resort? Drivers of Discretion at the European Central Bank
Authors: Donnelly Shawn
Published: December 2024

Under what conditions does the ECB become the policy-maker of last resort? This article surveys five incidences in which the ECB created its own rules or exercised discretion beyond the effective control of political principals. ECB rule-making took place where the Bank had an initial legal mandate to be present in the policy space, where it could exploit unique institutional interfaces with the banking community and Economic and Monetary Union system, where it had advantages in expertise and information, and where the Council either fully supported the ECB to design new powers, or was divided on whether to retrench ECB freedom. The article examines discretion in macroeconomic policy instruments, capital requirements for banks, including choices that have industrial policy (targeted sectoral) effects, the design of the digital euro, and ECB efforts to force the migration of UK-based financial services to the EU.
Breath Characteristics of Volitional Yoga Breathing and Breath Awareness
Authors: Telles Shirley , Sharma Sachin Kumar , Gandharva Kumar , Gupta Ami , Balkrishna Acharya
Published: December 2024

Changes in breathing during pranayama (yoga breathwork) are usually inferred from practice guidelines in traditional texts or contemporary writings. These changes point to understanding the effects of pranayama and indicate applications of pranayama in health. Previously, a pilot study on a single participant suggested that each pranayama changes breathing uniquely. To extend this research in the present study, 23 yoga practitioners (mean age 28.1 ± 3.8; 12 men, 11 women) who were able to practice the pranayama consistently were each studied in a 48-minute session with five pranayama practices—(1) alternate-nostril yoga breathing, (2) bellows yoga breathing, (3) bumblebee yoga breathing, (4) high-frequency yoga breathing, and (5) hissing yoga breathing—as well as (6) breath awareness for 3 minutes each. From strain gauge–recorded respiratory movements, the breath frequency, depth/amplitude of breathing, and inspiration:expiration were obtained. Compared to the baseline, breath rate increased during high-frequency breathing (373.3%) and decreased during bumblebee breathing (75.3%), hissing breathing (63.0%), and alternate-nostril breathing (55.3 %). The depth of breathing increased in alternate-nostril breathing (141.0%), bellows breathing (136.0%), bumblebee breathing (307%), high-frequency breathing (275.0%), and hissing breathing (95.0%). The inspiration:expiration increased in high-frequency breathing (177.0%) and decreased in bumblebee breathing (74.3%) and alternate-nostril breathing (39.0%). There were no changes during breath awareness. The changes in breathing (although limited by the small sample size) support previous reports of high-frequency breathing as being activating while enhancing attention, and of bumblebee and alternate-nostril breathing (hissing and bellows breathing to a lesser extent) as calming, with increased vagus nerve activity.
Alterations in paraoxonase-1 levels and oxidative status with the eradication of Helicobacter pylori infection
Authors: Akin Fatma Ebru , Demirezer Bolat Aylin , Işıkoğlu Hatıl Semra , Tayfur Yürekli Öykü , Özer Sarı Sevil , Büyükaşık Naciye Şemnur , Erel Özcan , Ersoy Osman
Published: December 2024

Background and Aims: To compare the plasma paraoxonase-1 levels and oxidative stress markers in patients with different states of Helicobacter pylori infection. Materials and Methods: Patients with dyspeptic symptoms and referred for upper gastrointestinal system endoscopy were consequently included and grouped according to the presence of Helicobacter pylori infection. Helicobacter pylori was eradicated in patients with positive rapid urase test. Total antioxidant status, total oxidant status and oxidative stress index were calculated. Paraoxonase-1 levels and oxidative stress markers were compared between 3 groups and in treated patients before and after eradication. Results: One hundred eighty nine patients were included the study. In eighty two patients Helicobacter pylori were positive without the presence of duodenal ulcer, in 49 patients Helicobacter pylori were positive with the presence of duodenal ulcer and Helicobacter pylori were negative in 58 patients. In evaluation of paraoxonase-1 levels in women, there were not any statistically significant difference between groups but Helicobacter pylori negative patients had statistically significantly higher values than other 2 groups among men. Total antioxidant status levels were statistically significantly higher in both genders in Helicobacter pylori negative patients than other 2 groups. There were a statistically significant increase in total antioxidant status and paraoxonase-1 levels with the successful eradication of Helicobacter pylori infection. Conclusion: Plasma paraoxonase-1 and total antioxidant status were decreased while total oxidant status and oxidative stress index were increased in the patients with Helicobacter pylori infection. The differences were more prominent in males who are more prone to atherosclerotic diseases. Moreover, with the eradication of Helicobacter pylori infection, both paraoxonase-1 levels and total antioxidant status were increased significantly
The Feminine and Masculine Dimensions of Earthquakes: A Gender-focused Sociological Research on the Victims of the 2023 Kahramanmaraş / Türkiye Earthquakes
Authors: Gürkan Senem
Published: December 2024

Objective: The current study aims to make sociological inferences on the victims of the 2023 Kahramanmaraş / Türkiye earthquakes in terms of gender.
Method: The participants of the study are 36 (19 women, 17 men) Kahramanmaraş / Türkiye earthquake doublet victims who were older than 18 and who settled to Samsun province of Türkiye after the disaster. The qualitative data were collected through in-depth interview technique and were analyzed through content analysis by using MAXQDA 2022 qualitative data analysis computer aided program to make contribution for increasing the reliability of the research.
Findings: The findings of the study, which were compatible with those of the former disaster literature, indicated that the earthquake doublet occurred consecutively rocking 11 provinces of Türkiye had effects on each and every resident living in those area regardless as their genders.
Conclusion: As women had already been vulnerable with pre-existing inequalities, this vulnerability further exacerbated and deepened, and a secondary disadvantage as being earthquake victims with more mortality rates make them experience multi-crisis.
Incidental finding of ectopic pancreatic tissue in gastric wall during laparoscopic sleeve gastrectomy: a case report
Authors: Hamdi Hafiz A. , Abdo Mohammed Y. , Alzahrani Khalid M.
Published: December 2024

Ectopic pancreatic tissue, or heterotopic pancreas, is a rare congenital anomaly defined by the presence of pancreatic tissue outside its usual location and without vascular or ductal continuity with the main pancreas. It is often asymptomatic and typically discovered incidentally during imaging or surgical procedures. We report the case of a 41-year-old female undergoing laparoscopic sleeve gastrectomy for morbid obesity (BMI: 44 kg/m²), during which a 17×9 mm nodular lesion was identified on the anterior stomach wall. Histopathological analysis confirmed ectopic pancreatic tissue, classified as Heinrich type I. This case highlights the importance of recognizing incidental findings during bariatric surgery and the need for thorough pathological evaluation to rule out malignancy or other complications.
Musculoskeletal simulation for patient transfer using hand load measurement device
Authors: Uchimura Ryo , Fushitani Ryohei , Kitagawa Kodai , Wada Chikamune
Published: December 2024

Background: Unsuitable posture in patient transfer motion causes lower back pain (LBP) among caregivers. The suitable postures to reducing lumbar loads during patient transfer are investigated by musculoskeletal simulation. However, existing musculoskeletal simulation cannot accurately predict lumbar loads because the existing musculoskeletal models are generated by only motion data. Thus, this study aimed to propose and evaluate an accurate musculoskeletal model using hand load data obtained from a hand load measurement device.
Methods: Motion and hand load data for the musculoskeletal model were measured during patient transfer by an inertial measurement unit (IMU)-based motion capture system and hand load measurement device. The existing model without using hand load data and the proposed model using hand load data predicted the activity of the erector spinae muscles and the compressive force of L4-L5. The correlation of erector spinae muscle activity was compared between the predicted and ground truth (surface electromyography) values. Furthermore, predicted compressive forces of L4-L5 were compared with reference value reported by previous study related to in vivo intradiscal pressures measurement.
Results: The proposed model could predict erector spinae muscle activity with a correlation that was significantly greater than that of the existing model (p<0.05). Furthermore, the proposed model could predict compressive forces of L4-L5 with approximate values close to in vivo intradiscal pressures measurement.
Conclusions: Proposed musculoskeletal model may more accurately predict lumbar loads during patient transfer than the existing model. Proposed musculoskeletal model will be applied to explore suitable postures for preventing LBP.
Notas sobre la ecología poblacional de Pholidobolus montium (Sauria: Gymnophthalmidae) en una localidad de Mulaló, Ecuador
Authors: Ramírez-Jaramillo Salomón M.
Published: December 2024

Durante seis meses de muestreo se evaluó una población de Pholidobolus montium en una localidad de Mulaló ubicada en un área intervenida con remanentes de vegetación nativa. Se establecieron dos puntos de muestreo: P1 y P2. En P1 se delimitó un área de 15 x15 m y se colocaron piedras con tamaños entre 15 x 15 cm y 40 x 30 cm. Se empleó el método de captura, fotoidentificación y recaptura y se estimó el tamaño de la población durante el periodo de muestreo. En P2 se delimitó un área de 10 x 10 m donde se realizaron capturas únicas durante dos días y se calculó la abundancia total del sitio. En P1 se hicieron 30 capturas-recapturas de 27 individuos únicos para una estimación de 124 individuos, es decir, una densidad poblacional de 1,8 individuos por m2. En P2 se hicieron 12 capturas únicas, lo que arrojó una densidad poblacional de 1 individuo por 8,3 m 2. En los dos sitios de muestreo, la longitud rostro cloaca (LRC) fue entre 2,6 y 9,1 cm. La cola intacta registra el mayor número de individuos en ambos sitios de muestreo, en P2, el porcentaje de colas regenerada y ausente fue mayor que en P1, considerando así que P2 está más expuesto a depredadores. En la comunidad de saurios andinos esta especie presenta simpatría con Pholidobolus affinis y Stenocercus cadlei.
Desarrollo y evaluación de celdas fotovoltaicas orgánicas nanoestructuradas
Authors: Romero-Atencio Jonathan , Ramos-Hernández Andrea Carolina , Romero-Colange Mario Alberto , Guy-Bernede Jean Christian , Cattin Guenadez Linda , Louarn Guy , Arteaga-Arroyo Gean Carlos
Published: December 2024

En este trabajo se explora la optimización y caracterización de celdas fotovoltaicas orgánicas que utilizan colectores de electrones nanoestructurados. Como material colector se utilizaron nanovarillas de óxido de zinc (ZnO), un material que ha sido ampliamente estudiado en este campo. Las nanovarillas de ZnO se sintetizaron mediante una técnica de deposición electroquímica en sustratos de vidrio recubierto de óxido de indio y estaño (ITO). Para el proceso de síntesis de las nanovarillas de ZnO se ajustó la temperatura de síntesis electroquímica a 70 °C durante una hora y el potencial de reducción fue de −1,0 V. Las películas obtenidas se caracterizaron utilizando difracción de rayos X (DRX), microscopio electrónico de barrido (SEM) y espectroscopía fotoelectrónica de rayos X (XPS). Se emplearon películas de ZnO/ITO como cátodo en las celdas fotovoltaicas fabricadas. Se construyeron siete dispositivos en los cuales se evaluó la influencia del ZnO, del polímero conjugado P3HT y del derivado del fullereno PCBM como materiales activos, así como de las configuraciones de estructura clásica e inversa de la celda. Se registraron las curvas características J-V para los dispositivos construidos y se encontró que aquellos que no tenían las nanovarillas de ZnO presentaron un mejor comportamiento. Los mejores resultados se dieron con la configuración clásica PHJ-OPVs Vidrio/ITO/MoO3 (5 nm) /P3HT:PCBM/LiF (1 nm) /Al (100 nm), para la cual los valores obtenidos fueron Jsc = 4,9 mA/cm2, Voc = 0,4 V y FF = 34,9 bajo iluminación, en tanto que la eficiencia de conversión de energía (η) fue del 0,7 %.
Malvaceae neotropicae novae vel minus cognitae XII. Nuevas especies de Matisia de Colombia y Panamá
Authors: Fernández-Alonso José Luis , Campos-Pineda Ernesto
Published: December 2024

Como parte de los trabajos de revisión que se adelantan en el género neotropical de árboles Matisia (Malvaceae), más concretamente en relación con las secciones Calyculatae y Longipedes, se describen en este trabajo seis especies nuevas. Cuatro de ellas se adscriben a la sección Longipedes (M. genesiana, M. petaquillae, M. mutatana y M. changuinolana) y las otras dos a la sección Calyculatae (M. rufula y M. aquilarum). De ellas, tres se conocen únicamente en territorio panameño y las otras tres en Colombia.
Primeras fechas arqueológicas tempranas en la sierra de Nariño (Colombia): asentamientos humanos y actividad del volcán Galeras
Authors: Cárdenas-Arroyo Felipe , González-Fernández Víctor , Bernal-Vélez Alejandro , Gómez Daniel Alejandro , Acevedo Gómez Natalia
Published: December 2024

En este trabajo presentamos los resultados de las excavaciones arqueológicas adelantadas en el municipio de Consacá, vereda Bajo Bomboná, en el departamento de Nariño (Colombia), donde se evidenció la presencia de asentamientos humanos fechados por radiocarbono a partir del segundo milenio a.C. Este sitio temprano se caracteriza por la presencia de artefactos de obsidiana y la ausencia de cerámica asociada a ellos. El origen de esta obsidiana es la fuente natural de Mullumica, en Ecuador y, posiblemente, también de fuentes naturales de obsidiana del complejo volcánico de Sotará (Cauca/Huila). Su presencia en Nariño no se debe a un fenómeno geológico sino a su transporte por parte de personas hace cuatro milenios. En las excavaciones también se evidenció la contemporaneidad de la actividad del volcán Galeras y otros fenómenos geológicos caóticos con la presencia de poblaciones humanas asentadas en el curso medio del río Guáitara en los siglos X y XI d.C. La evidencia arqueológica sugiere que el territorio ha estado ocupado por poblaciones humanas durante cuatro mil años. Los análisis petrográficos realizados tanto en la cerámica, fechada mediante termoluminiscencia en época más tardía, como en los artefactos líticos distintos de la obsidiana sugieren que las materias primas que se usaron en su fabricación son de origen local.
Yeni Medyanın Çevrimiçi Radikalleşme İşlevi
Authors: Asıl Sermin
Published: December 2024

Bu çalışmanın amacı, çevrimiçi radikalleşme olgusunda yeni medya aracı olan Twitter’ın etkisini belirlemektir. Twitter (X), insanları bilgilendirme, eğitme ve kamusal alanı dönüştürme işlevlerinin yanı sıra yankı odası, filtre balonu ve hiperkişiselleştirme algoritmalarının etkisiyle benzer medya kültürü ve dünya perspektifinin yaygınlaşmasına katkıda bulunmaktadır. Bu durum duygu, düşünce, inanç ve davranışların ortaklaşmasını, buna uyum sağlamayanların ise kolaylıkla ötekileştirilmesini mümkün kılmaktadır. Özellikle memnuniyetsizlik yaratan bir konu ya da olayda, çoğunluk hissine dahil olmayan bireyler daha kolay ötekileştirilmektedir. Bu süreç, radikalleşme bağlamında memnuniyetsizlik yaratan kişi ya da kurumlara yönelik basit bir şikayetin zamanla nefrete dönüşmesine neden olmaktadır. Günümüzde bu dönüşüm çevrimiçi platformlar aracılığıyla gerçekleşmekte ve radikalleşmenin bilişsel boyutunu oluşturmaktadır. Bu bağlamda, Türkiye’de 2023 yılında gerçekleştirilen seçimlerle ilgili paylaşılan içerikler, #secim etiketi ile toplanmış ve tümevarımsal tematik analiz yöntemi ile incelenmiştir. Yapılan analizler sonucunda on bir ana tema belirlenmiş ve bunlardan “seferber etmek”, “suçlamak” ve “mağduriyet” temalarının doğrudan çevrimiçi radikalleşme ile ilişkili olduğu görülmüştür. Ayrıca, ortaya çıkan kırk dokuz alt tema arasından on dört tanesi çevrimiçi radikalleşme ile doğrudan bağlantılı çıkmıştır. Bununla birlikte, çevrimiçi radikalleşmeyle ilişkili olan temaların bilişsel radikalleşmeyi etkilediği, davranışsal radikalleşme ile yalnızca “illegal eyleme davet” alt temasının ilişkili olduğu tespit edilmiştir. Sonuç olarak, Twitter’ın çevrimiçi radikalleşmeyi bilişsel boyutta etkilediği, siyasetin bu radikalleşmeyi artırdığı ve analiz edilen temaların radikalleşme teorileriyle açıklandığı sonucuna varılmıştır.
The Right of Everyone to Favorable Environment in the Russian Federation: Relevant Ensuring Problems
Authors:   Senior Research Scientist of the Department of Environmental, Land and Agrarian Law of the Institute of State and Law of the Russian Academy of Sciences, Rednikova Tatyana V.
Published: December 2024

The article analyzes the concept of a favorable environment, considers the content of the relevant constitutional
right, and points out the absence of legislatively enshrined criteria for a favorable environment. It is emphasized that
in order to ensure human rights to a favorable environment, control over the state and change of the environment and
natural resources should be established at the national level. It is indicated that the right to a favorable environment has
a pronounced public character, and the guarantee of its implementation is important not only for individual citizens,
but also for the whole society. The article reflects certain of the most pressing problems of implementing this right today.
Problems of Applying Russian Inheritance Law Provisions on Joint Will of Spouses
Authors:   Plenipotentiary of the Government of the Russian Federation in the Constitutional and Supreme Court of the Russian Federation, Barschevskiy Mikhail Yu.
Published: December 2024

The article reviews various means of posthumous property disposal. Special attention is paid to such form as a joint
will of spouses.
The Influence of Trademarks on the Consumer Markets Development. Part 1.
Authors:   of the Department of Individualization Means Registration of the Federal Institute for Industrial Property, Razumova Galina V. , Orlova Elena D. ,   Deputy Head of the Department of Individualization Means Registration of the Federal Institute for Industrial Property, Rozhnova Diana A. ,   Head of the Department of National Projects and State Programs Support of the Public Authorities Interaction Center of the Federal Institute for Industrial Property
Published: December 2024

The article represents the overview of the research “The Impact of Trademark Use on the Development of Consumer
Market in Russia”, which corresponds to the preliminary report of the research. The relevance of the research is determined
by the investigation of the conditions for consumer promotion, applied to the usage of trademarks, service marks and the
disposal of exclusive trademark rights. The practical value of the research is conditioned upon the need to systematise
the subjects of information law (marketplaces) and the scope of their digital rights. Due to the expansion of the subject
composition of applicants for trademark registration as well as the increase in the business activity of Russian applicants,
the authors agree on the importance of analysing the key factors of growth in the number of applications and trademarks in
order to identify some further conditions for stimulating the consumer goods market of the Russian Federation regarding
the use of trademarks, service marks and disposal of exclusive rights to trademarks.
Provision of Information to Consumers as a Prerequisite of Ensuring Safety and Quality of Goods and Services
Authors:   Postgraduate Student of the Department of Civil Law and Civil Procedure of the A.S. Griboyedov Moscow University, Barkhatov Vladimir Yu.
Published: December 2024

The article considers the current problems of informing consumers, protection of their right to receive information,
it is noted that the legislative regulation in this area is limited mainly by the requirements related to the safety of products,
and scientific research is mainly devoted to the problems of informing consumers in certain areas of entrepreneurial
activity, in the sale of certain categories of goods and provision of certain types of services.
It is noted that it is necessary to develop general principles for assessing the reasonableness and good faith of the
behavior of manufacturers, sellers and performers, as well as consumers themselves, when considering specific situations
related to the fulfillment of consumer information obligations.
On Efficient Use of Oil and Gas Proceeds of the National Welfare Fund
Authors:   Postgraduate Student of the Higher School of Law of the Yugra State University, Kugaevskiy Danila V.
Published: December 2024

The article is devoted to the analysis of recent changes related to the effective use of excess profits in the oil and
gas sector. The article analyzes the difficulties associated with the creation and operation of monetary reserves, which
are replenished mainly from income received from the oil and gas industry. The author suggests ways to further reform
the national welfare Fund through solving practical problems faced when using funds from the National Welfare Fund
(hereinafter – NWF). As a result, unique approaches have been developed to address the identified problematic issues.
Conclusions are drawn about the need for further reform of the NWF in order to ensure stability, economic security of
the population and future generations.
Factors Promoting Transformation of the Global Logistic Model in the New World Order Paradigm
Authors:   Professor of the Department of International and Public Law of the Financial University under the Government of the Russian Federation, Vice-Rector for Research and Innovations of the International Law Institute, Cherdakov Oleg I.
Published: December 2024

The article proposes the author’s position, which allows to determine the factors that contribute to the change
of the logistics model in modern realities. The aspects that testify to the fifth logistic revolution, which is taking
place in the current realities, are revealed. Trends in the formation of new logistics corridors are revealed, through which
not only trade routes will change, but also the role of a number of Asian and African countries will increase.
Liquidated Damages
Authors:   Attorney, Partner at AB Arbitr Moscow Bar Association, PhD (Law), Belolikov Aleksey I.
Published: December 2024

The article makes a legal analysis of the category of liquidated damages. The author summarizes such three elements
as the concept of damages, agreement and estimate (price) and concludes that it is unacceptable for the court to change
the agreed fixed amount of damages as a general rule.
Psychologia prześladowań w szkole
Authors: Smith Peter K. , Piszczek Katarzyna
Published: December 2024

Dlaczego dzieci stają się częścią zjawiska, jakim jest prześladowanie? Czy cyberprzemoc różni się od tradycyjnego prześladowania? W jaki sposób można zapobiegać prześladowaniu w szkole?
W Psychologii prześladowań w szkole zgłębiamy, czym jest prześladowanie i jakie czynniki prowadzą do tego, że dzieci wchodzą w role prześladowców, ofiar, obrońców, świadków czy też nawet kombinacje tych ról. Książka zawiera omówienie strategii zapobiegawczych zmniejszających prawdopodobieństwo wystąpienia prześladowania w szkole, a także przegląd działań, jakie placówka może podjąć, jeśli będą w niej miały miejsce incydenty związane z prześladowaniem.
Prześladowanie ma daleko idące konsekwencje, a jego skutki są czasami tragiczne, więc niezbędne jest zrozumienie, dlaczego i w jaki sposób do niego dochodzi. Psychologia prześladowań w szkole umożliwia poszerzenie wiedzy na ten temat w celu podejmowania efektywnych interwencji.
Effects of Different Fertilizer Types on Pigment Content and Some Stress Molecules in Perennial Ryegrass (Lolium perenne L.)
Authors: Yıldırım Gözde Hafize , Ay Ebru Batı , Şengür Şeyma
Published: December 2024

Background: Perennial ryegrass (Lolium perenne L.) is a grass species known for its dark green color, fine texture and rapid germination in cool seasons. Its resilience to hot, dryand cold weather conditions makes it suitable for both warm and cool climates. Its high resistance to wear stress makes it an ideal plant for sports fields. The use of chemical fertilizers leads to the accumulation of toxic elements in the soil, reducing productivity and polluting water sources. In contrast, organic or biofertilizers improve soil structure, increase water retention capacityand enhance the effective use of plant nutrients. This results in high yields while ensuring environmentally friendly agricultural practices that protect human and animal health. Methods: In this study, perennial ryegrass was treated with six different types of fertilizers (liquid seaweed fertilizer, microbial liquid organic fertilizer, organic liquid vermicompost, chicken manure, bat guanoand fertilizer with 32 micro trace elements) at four different fertilizer doses (2%, 4%, 6% and 8%). A control group with no fertilizer application was also included. The study investigated the effects of fertilizers on the plant’s chlorophyll-a (mg/g), chlorophyll-b (mg/g), total chlorophyll (mg/g), chlorophyll a/b ratio, carotenoid (mg/g), proline (µmol/mL), MDA (Lipid peroxidation activity) (nmol/g), APX (Ascorbate Peroxidase) (EU/ml) and Catalase (EU/ml) levels. Result: The results showed that chlorophyll a content ranged from 3.68 to 0.35, chlorophyll b from 2.07 to 0.22 and total chlorophyll from 5.75 to 0.56, while the chlorophyll a/b ratio was between 2.65 and 1.46. Carotenoid content ranged from 1.01 to 0.14and ascorbate peroxidase activity was measured between 29.02 and 0.67. Catalase activity varied from 175.80 to 11.54, proline content from 48.05 to 1.15 and lipid peroxidation (MDA) levels ranged from 1.50 to 0.36. These results demonstrate that different treatments have significant and wide-ranging effects on the physiological and biochemical parameters of plants.
Tattoos and Body Modification: Culture, Therapy, and History
Authors: Cárdenas Karen Andrea , Torres Aura Marcela
Published: December 2024

Tattooing has been transforming its meaning over time, it is a practice related to fashion, the dominance of aesthetics over the body, beliefs, forms of expression and identity, a practice that has become commonplace in contemporary societies. The article is divided into two segments. The first summarizes a detailed review of 152 publications exploring various aspects of tattooing derived from a systematic review of the scientific production surrounding tattoos and how they have been conceived over time. The second includes an analysis of these articles based on their theoretical and conceptual contributions, expanding the literature on the study of tattooing (in categories such as: anthropological, gender perspectives, work environment considerations, medical factors and body modification practices). This research revealed a broad spectrum of conceptual and epistemological perspectives that have influenced the practice of skin inscription. It also highlights the important role that tattoos play in the practice of skin inscription.
Guided Mindfulness-Acceptance Self-Help Intervention for Dysphoric Students: Preliminary Findings
Authors: Tovilović Snežana , Novović Zdenka , Mihić Ljiljana , Petrović Tanja
Published: December 2024

The purpose of this pilot study was to test the efficacy of a novel self-help program called Attention training (AT) based on the mindfulness-acceptance principles in a sample of dysphoric students. We tried to determine if the program: a) contributed to immediate and follow-up changes in the presumed components and mechanisms of mindfulness-acceptance - psychological flexibility, attention control (switching and updating), and rumination; b) was followed by a reduction in dysphoric symptoms; c) had different effects depending on a different order of exercises within AT. The final sample consists of 18 students from the University of Novi Sad, 19-29 years old with mild and moderate depression (selected through pre-screening procedure). Data were collected at 4 measurement occasions:  before the first group meeting (pretest), right after completion of all exercises (posttest), and two follow-ups - one and three months post-treatment. AT consisted of 8 small-group, weekly meetings (up to 5 persons and < 90 minutes of overall therapist support). Participants listened to the audio-recorded exercises that targeted the somatic, emotional, and cognitive domains. The sample was randomly split into two groups with a different order of the emotional and cognitive exercises.  We found that AT, as a self-help intervention, can potentially lead to improvements in the mindfulness components and mechanisms, even though an increase in the depressive symptoms was noticed. Different explanations were provided for such findings, including suggestions for further optimization of the program and recommendations for further research.
Gender differences in left-right ideology: European men are more right-wing, women are more centrist?
Authors: Trogrlić Aleksandra , Todosijević Bojan
Published: December 2024

Since the 1990s, women appear to have become more left-wing or liberal-oriented compared to men (Dassonneville, 2020). In this paper, we examine whether this observation holds in the more recent survey data from Europe. We show that the exclusive focus on differences in average scores provides an incomplete picture of gender differences in ideology. Since both men and women tend to be centrist, the observed gender differences in averages may be due to differences in the relative popularity of the middle point of the scale. The analysis uses the ninth wave of the European Social Survey data (ESS 9.3), which covers 29 European countries. The results show that European women are, indeed, on average, positioned to the left compared to men. However, additional analyses revealed that these differences are partly due to men's preference for rightist ideological positions and partly to women's relatively more frequent positioning on the scale midpoint.
Cultural Values In The Film 'Najih' By Pondok Pesantren Dalwa Charles Sanders Peirce's Semiotic Analysis
Authors: Hartono Alfina , Rohanda Rohanda , Fauziah Isma
Published: December 2024

This research aims to describe the cultural values contained in the film "Najih" by Pondok Pesantren Dalwa. The film Najih tells the story of a young man who is determined and never gives up in his journey to learn Arabic. This research is a qualitative descriptive study that uses the research object in the form of the film "Najih" by Pondok Pesantren Dalwa. This research focuses on the film "Najih" with objects in the form of stills from different scenes in the film. Researchers classify signs based on representation, object and interpreter. Through the analysis applied, a lot of data was found that revealed the cultural values in the film "Najih". These cultural values include elements such as knowledge, belief, art, morality, law, customs, skills and habits. This can be seen from the data presented in the research.
The Role of Ilha Study Program Students in Spreading the Values ​​of Religious Moderation on Social Media
Authors: Mifta Miftahul Janah , Ahmad Arifi  , Indal Abror
Published: December 2024

The main aim of this research is to understand and analyze in depth how students from the Al-Qur'an and Tafsir Science Study Program (Ilha) play an active role in spreading the values ​​of religious moderation through social media. This research problem focuses on the important role of the younger generation, especially Ilha Study Program students, in facing the challenges of radicalism and intolerance which are often spread through social media. This research tries to answer the question of how Ilha Study Program students can become agents of change in spreading the values ​​of religious moderation in the digital space. Qualitative research method with field research type, conducting in-depth interviews with Ilha Study Program students to dig deeper into the i, challenges, strategies, as well as supporting and inhibiting factors they face in spreading the values ​​of religious moderation.    The results of this research can provide a comprehensive picture of the role of Ilha Study Program students in spreading the values ​​of religious moderation on social media. identify strategies used by Ilha Study Program students, such as creating creative content, online discussions, social media campaigns, and collaboration with other parties. The challenges faced are lack of good understanding or just following trends, and manipulation of information or hoax news. The supporting and inhibiting factors for Ilha Study Program students in spreading the values ​​of religious moderation are the influence of peers, being quick and interactive, while the inhibiting factors are a lack of increasing understanding or reducing negative content on social media
Aliran Kepercayaan dan Kebatinan: Sebuah Fenomena Keindonesiaan
Authors: Wijaya Wijaya
Published: December 2024

Keberagaman aliran kepercayaan dan kebatinan di Indonesia telah ada sejak zaman nenek moyang dan bertahan hingga kini. Setiap aliran, seperti animisme dan kebatinan, memiliki karakteristik unik di tiap wilayah tetapi berbagai inti spiritual yang menekankan harmoni antara manusia, alam, dan Tuhan menunjukkan bahwa setiap aliran mengutamakan nilai-nilai seperti pengendalian diri dan kesejahteraan sosial.  Nilai-nilai ini tidak hanya memperkaya kehidupan spiritual individu tetapi juga berkontribusi pada pembangunan etika sosial yang harmonis dalam Masyarakat. Aliran kepercayaan ini memberikan wawasan penting dalam memahami spiritualitas dan budaya bangsa yang beragam di era modern.
Estudio ABC/VEN de la lista de medicamentos del Hospital Docente Ginecobstétrico América Arias, La Habana, 2021
Authors: Gutiérrez-García Daniela , García Fariñas Anai , Elías-Díaz Ingrid Elías-Díaz , Martínez-Álvarez Igna María
Published: December 2024

Objective: To characterize the list of drugs used at the Hospital Docente Ginecobstétrico América Arias in 2021, according to their clinical and economic relevance, through the ABC/VEN matrix.
Materials and Methods: A descriptive observational study was carried out that considered the number of medicines and the associated expenditure generated according to ATC therapeutic groups, country of origin, route of administration, ABC, VEN and ABC/VEN classification in the year 2021.
Results: The Medicines List included 358 products. There were 25 medicines in category A, representing 3 essential medicines, 3 special medicines, 18 vital medicines and 1 non-essential medicine but representing high consumption in category A; with a total group expenditure of 3,724,633.42 CUP, 75 medicines in category B, with an expenditure of 1,037,713.04 CUP and 258 medicines in category C, with an expenditure of 229,885.20 CUP.
Conclusions: The application of ABC-VEN analysis allowed effective clinical-economic classification of drugs. The high presence of antimicrobials underscored the need to strengthen microbiological surveillance and the performance of antibiograms. The inclusion of non-essential drugs with high cost (vaginal Ketoconazole) should be reviewed. The combination of ABC and VEN methods allowed a more exhaustive control of critical drugs, optimizing the use of the hospital budget.
 
Keywords: List of essential drugs, ABC Analysis, VEN Analysis, ABC/VEN Matrix.