bluuebunny/crossref_metadata_2025 huggingface dataset:
A thromboxane A2 receptor-dependent feedback loop that affects the homeostasis and angiogenic capacity of endothelial cells
Authors: Eckenstaler Robert , Ripperger Anne , Hauke Michael , Schwedhelm Edzard , Ergün Süleyman , Werz Oliver , Koeberle Andreas , Braun Heike , Benndorf Ralf
Published: March 2022

Background and purpose: The thromboxane A2 receptor (TP) plays an
eminent role in the pathophysiology of endothelial dysfunction and
cardiovascular disease. Moreover, its expression is reported to increase
in the intimal layer of blood vessels of cardiovascular high-risk
individuals. Yet it is unknown, whether TP upregulation per se has the
potential to affect the homeostasis of the vascular endothelium.
Experimental approach and key results: Here we report that increasing
endothelial expression of both human TP isoforms induces endothelial
cell tension and aberrant cell morphology, affects focal adhesion
dynamics and inhibits the angiogenic capacity of human endothelial cells
in vitro and in vivo, whereas TP knockdown exerts opposing effects.
Combined global transcriptome, lipidomic, functional live-cell and
validating expression analyses reveal that endothelial TP upregulation
induces cyclooxygenase-2 in a Gi/o and Gq/11-dependent manner, thereby
promoting its own activation via the auto/paracrine release of TP
agonists, such as prostaglandin H2 or prostaglandin F2 but not
thromboxane A2. Consequently, this TP-dependent angiostatic feedback
loop is disrupted by pharmacological TP or cyclooxygenase-2 inhibition
and by genetic reconstitution of prostaglandin H2-metabolizing
prostacyclin synthase even in the absence of functional prostacyclin
receptor expression. Further mechanistic analyses of downstream TP
effectors disclose that the TP induces endothelial cell tension, focal
adhesion dysregulation and angiostatic effects via a ROCK-LIMK2-myosin
II-dependent signal transduction pathway and downregulates important
mediators of endothelial cell homeostasis, e.g. VEGFR-2. Conclusions and
implications: Our work uncovers a previously unrecognized mechanism, by
which pathological endothelial upregulation of the TP could directly
foster endothelial dysfunction, vascular rarefaction and systemic
hypertension.
Noninvasive Assessment of Cardiac Changes in Patients with Coronavirus Disease-19 (COVID-19) by Bedside Ultrasound
Authors: Gao Ziqing , Huang Yongquan , Lu Wuzhu , Chen Xiaobo , Li Xuefeng , Zhang Shushan , Su Zhongzhen
Published: March 2022

PURPOSE: This study was conducted to explore the value of noninvasive
assessment of bedside ultrasound in diagnosing cardiac changes of
COVID-19. METHODS: We performed a retrospective study in 34 patients
with COVID-19 and analyzed their clinical data, biochemistry test
results (creatine kinase-MB [CK-MB], cardiac troponin I [cTnI]
and C-reactive protein [CRP]), and parameters of cardiac ultrasound
(left atrium [LA], left ventricular end-diastolic dimensions
[LVDD], right atrium [RA], right ventricle [RV], main
pulmonary artery [MPA], left ventricular ejection fraction
[LVEF], tricuspid valve [TV], pulmonic valve [PV] and
pulmonary artery systolic pressure [PASP]). We classified the
patients based on their clinical symptoms: mild, moderate, severe, and
critical groups, and compared the parameters. RESULTS: As the disease
progressed, the parameters of both biochemical blood tests and cardiac
ultrasound changed regularly, manifested as enlargement of LA, LVDD, RA,
RV, and MPA and increase of PASP, CRP, CK-MB, and cTnI. Of these
parameters, CRP, LA, LVDD, MPA, and PASP of the severe group were more
notably elevated than those of the mild and the moderate groups
(p<0.05). The critical group increased more markedly in CK-MB,
cTnI, and RA than the other groups (p<0.05), and rose more
sharply in CRP, LA, LVDD, RV, MPA, and PASP than the mild and the
moderate groups (p<0.05). CONCLUSION: As the disease
progressed, the patients had the enlarged heart with expanded pulmonary
arteries and elevated PASP. Bedside ultrasound can be a noninvasive
assessment of the above changes and a guidance of clinical treatment.
THE TRANSFORMATIVE POWER OF SUFFERING AND THE PERSONAL MEANING OF THE PERSONS WITH CHRONIC DISEASE IN COVID 19 PANDEMIA
Authors: atik DERYA , Manav Ayşe İnel , Bozkurt Adile , Coşkun Ejdane
Published: March 2022

Rationale, aims, and objectives The COVID-19 pandemic has led to
significant lifestyle changes in individuals who need to be under
constant control due to chronic disease. Individuals with chronic
diseases can be expected to suffer more for reasons such as fear,
anxiety, stress, uncertainty during the pandemic process. Suffering can
cause the meaning of life to be questioned and positive personal meaning
characteristics to develop. In COVID-19 pandemic, it was aimed to
evaluate the transformative power of suffering and the level of personal
meaning perceived in individuals with chronic diseases and to determine
the effect of suffering on personal meaning. Methods The study was
planned descriptively and cross-sectionally. The data were collected
online in Turkey. 407 samples were reached between May and August 2020.
The data were collected using the Personal Information Form The
Transformative Power of Suffering Scale and The Personal Meaning Profile
– Brief. Results As a result of the study, The Transformative Power of
Suffering Scale mean score was 24.65 ± 6.30, and The Personal Meaning
Profile – Brief mean score was 113.98 ± 17.58. As a result of the
correlation analysis; a positive correlation was determined between the
The Transformative Power of Suffering Scale, The Personal Meaning
Profile – Brief and sub-dimensions (p≤0.05). Conclusion As a result of
the study, the transformative power of suffer and perception of personal
meaning of the individuals in general were determined to be above the
middle level according to the scale scores. It was found that as the
transformative power of suffer increased, the perception of personal
meaning increased in individuals. It can be said that individuals who
have a high transformative power of suffer, who can adapt to changes in
the pandemic process, and who have a high level of education and income
have better perceptions of personal meaning.
Central nervous system complications and white matter lesions by brain MRI in pediatric hematological malignancies
Authors: Sugiyama Minako , Hirabayashi Shinsuke , Terashita Yukayo , Cho Yuko , Iguchi Akihiro , Manabe Atsushi
Published: March 2022

Several central nervous system complications in pediatric patients with
hematological malignancies have been reported. We analyzed the frequency
and the correlation with central nervous system involvement and
intrathecal therapy. The frequency was 13 % (11/85), being almost equal
to those in literature. We investigated high intensity areas, which
indicated leukoencephalopathy, in the white matter by T2-weighted and/or
fluid attenuated inversion recovery images (FLAIR) of the brain magnetic
resonance imaging (MRI). Incidence of white matter lesions was higher in
patients who received over 10 times of intrathecal therapy (p = 0.018).
Patients who received repetitive intrathecal therapy should undergo
close MRI to find out if they need cognitive functioning test. However,
it may be possible to omit brain MRI in patients with acute myeloid
leukemia and lymphoma who have received intrathecal therapies less than
five times in a consideration of their burden in terms of sedation and
cost.
Predictive factors of acute respiratory events during initial induction chemotherapy in patients with advanced neuroblastoma
Authors: Matsui Motohiro , Makimoto Atsushi , Nishio Nobuhiro , Takahashi Yoshiyuki , Urashima Mitsuyoshi , Yuza Yuki
Published: March 2022

Background The present study aimed to identify the predictive factors of
acute respiratory events (ARE), including severe hypoxia, during initial
induction chemotherapy in patients with newly diagnosed advanced
neuroblastoma. Method The medical records of 75 consecutive patients in
whom stage III or IV neuroblastoma was newly diagnosed between January
2003 and December 2018 at two medical institutions were retrospectively
reviewed. The outcome was ARE concomitant with severe hypoxia between
the first and 14th days of initial induction chemotherapy. Severe
hypoxia was defined as grade 3 or higher according to the Common
Terminology Criteria for Adverse Events version 4 (CTCAE v4.0) or
decreased oxygen saturation at rest (e.g., pulse oximeter <
88% or PaO2 ≤ 55 mmHg). Possible predictive factors on admission were
first screened for using univariate analyses with a P value of 0.05,
then models of the predictive power of the outcome were evaluated by
generating receiver operating characteristic (ROC) curves. Results
Eleven patients (14.7%) had the outcome, including three (4.0%) who
required respiratory support in the intensive care unit. The area under
the curve of the ROC for the predictive factors screened by univariate
analyses were 0.84 (95% confidence interval (CI): 0.73-0.95) for
lactate dehydrogenase (LDH) and 0.90 (95% CI: 0.82-0.98) for the
disseminated intravascular coagulation (DIC) score. Conclusion The LDH
value and DIC score on admission may be clinically useful predictors of
ARE during initial induction chemotherapy in patients with advanced
neuroblastoma.
Why did Patients Admit to Physical Medicine and Rehabilitation Outpatient Clinic Despite the Risk of COVID-19?
Authors: SANAL-TOPRAK CANAN , Ozsoy-Unubol Tugba , Gunduz Osman Hakan
Published: March 2022

Objective: The aim of this study was to investigate the characteristics
of patients who applied to physical medicine and rehabilitation (PM&R)
outpatient clinics of two pandemic hospitals despite the risk of
COVID-19 infection. Methods: Patients who were admitted to PM&R
outpatient clinics of two pandemic hospitals in April and May 2020 were
retrospectively scanned from hospital records. Age, number of
admissions, the reason of admission, diagnosis and the prescribed
medications were recorded. The descriptive statistical methods were
employed. For the comparison of means student-t test was used. Results:
A total of 1078 patients (female 606, male 472) admitted to two tertiary
referral hospitals’ PM&R outpatient clinics. The ages of patients
ranged from 0 to 88 years with a mean age of 45.4±14.9 years. The most
common reasons for admission were acute peripheral joint pain (290),
follow-up and prescription (244) and acute low back pain (140),
respectively. The most commonly affected joint was the shoulder and
followed by the knee. Most frequent causes for follow-up and
prescription were fibromyalgia and neuropathic pain, and pregabalin and
duloxetine were mostly prescribed medications for these patients.
Conclusion: Acute pain may be considered as the most important condition
for admission of patients to PM&R outpatient clinics. Regardless of its
source, pain has a negative impact on patients’ lives and causes
hospital admissions despite the risk of infection. This effect is more
prominent in patients with fibromyalgia and neuropathic pain.
Gynaecological polyps: A systemic review
Authors: Shah Syed Joun , Khadija Syeda , Naveed Fatima , talat hafsa , suleman taiba , zahra tehreem , hina miss gull , asghar azka
Published: March 2022

Background: Polyps of the lower reproductive tract are found in 7.8-50%
of women. Endometrial polyps located at the fundal and tubocornual
regions mechanically affect fertility. The recent advances in TVU and
hysteroscopy provide an accurate diagnosis and effective treatment of
polyp in the female reproductive tract. Objective: The goal of this
systematic review is to highlight updates to the epidemiology, clinical
presentation and imaging modalities for gynaecological polyps providing
guidance to the best clinical decisions. It also highlights prevalence
of infertility in gynaecological polyps. Study Design: Systemic review
Material and methods: During December 2020 we searched Google scholar,
Pub med, Medscape, Web of Science, Scientific Information Database and
Magiran research articles from 2010 -2020. The selected articles
identified through electronic search were 60 articles and 50 were
selected for the review. Results: Endometrial polyps are the most
frequently diagnosed type of gynaecological polyp. They have been
implicated in 50% cases of abnormal uterine bleeding and 35% patients
with infertility. The developments of high-resolution 2D and 4D
ultrasound, contrast sonography and hysteroscopy helps the clinicians in
diagnosing polyps efficiently. Hysteroscopy is the gold standard and
histology is essential for the ultimate diagnosis and malignancy
exclusion. Conclusions: The review of literature suggest that the polyps
are common cause of abnormal uterine bleeding and have strong
association with infertility. Polyps can be confidently diagnosed on
ultrasound with Doppler imaging. Hysteroscopy and histopathological
evaluation is considered essential for diagnosis of gynaecological
polyps. Key words: Endometrial polyp, Cervical polyp, Infertility,
Ultrasonography, Sonohysterography, Hysteroscopy.
Water loss and response to desiccation of Castanopsis sclerophylla (Fagaceae) seeds
Authors: Li Jiajin , Jaganathan Ganesh , Kang Han , Liu Baolin
Published: March 2022

In many -but not all- recalcitrant Quercus seeds, water loss
during drying only occurs through scar. Consequently, embryo sitting on
the opposite side of scar is well protected from desiccation. However,
whether such mechanism is common throughout Fagaceae species is
unexplored. Similarly, little is known about the desiccation response of
other Fagaceae genera. Germination and desiccation tolerance of
Castanopsis sclerophylla (Fagaceae) were studied by drying the
seeds. Fresh seeds had a moisture content (MC) of 36% and germinated to
93% when incubated at 15/20°C. Drying seeds to 22.5 and 20.7% MC
decreased germination to 27 and 0%, respectively; indicating seeds are
recalcitrant. X-ray computed tomography and photomicrographs showed that
embryo of C. sclerophylla sits just below scar. Regardless of
drying occurring either through only scar or whole pericarp, embryo
drying was deemed unavoidable. Nevertheless, germination percentage
during drying showed exceptional similarities with the other Fagaceae
species.
Children Deaths Due to Foreign Body Aspiration
Authors: Gok Ertugrul , Fedakar Recep , Sivri Suleyman
Published: March 2022

Background: Foreign body aspiration (FBA) in childhood is a common and
fatal accident. This study aimed to investigate the prevalence and
epidemiological characteristics of pediatric patients who have died as a
result of foreign body aspiration between 2005-2014 in XXXXXXX/XXXXX.
Methods: In this retrospective study, medicolegal reports of pediatric
cases who died as a result of foreign body aspiration and were autopsied
between 2005 and 2014 and were examined by the xxxxxxx Forensic Medicine
Institute. The analysis of the research data was done with the
Statistical Package for the Social Sciences Results: A total of 6309
forensic autopsies were performed between the years examined, 0.8%
(n=51) of them were child deaths due to foreign body aspiration. The
average age of the cases was found to be 2.10 ± 2.90, 90.2% of them are
in the 0-4 age range. 60.8% of the cases are male. 82.4% of the
aspiration material is vegetative products. In terms of foreign body
localization, obstruction was found in both main bronchus distal in
45.1% of the cases. Conclusion: It is thought that increasing the
awareness of parents and professional caregivers against foreign body
aspiration and having received first aid training may lead to a decrease
in the incidence and mortality rates.
Catastrophic cerebral sinovenous thrombosis with hemorrhagic conversion in a new diagnosis of pediatric acute myelogenous leukemia
Authors: Nessle Charles , Rivas-Rodriguez Francisco , Weyand Angela
Published: March 2022

This report describes a previously healthy toddler initially diagnosed
with acute myelogenous leukemia with monocytic features and a bilateral
thalamic high grade glioma at initial presentation. However, review of
the outside hospital imaging favored bilateral thalamic infarcts with
hemorrhagic conversion; the diagnosis of near diffuse cerebral venous
sinus thrombosis (CSVT) with hemorrhagic conversion was confirmed with
CT venography. He succumbed to uncontrollable intracranial pressure
despite surgical decompression, medical management, anticoagulation, and
chemotherapy. CSVT is the most common thrombotic complication present at
diagnosis in AML and associated with high mortality, and diagnosis
requires a high level of suspicion.
Kinetic analysis of viable but nonculturable Legionella inactivation using ozone
Authors: jun li , Liu Lin , Zhang Jiayong , Li Hanyi , Li Kunquan , Dou Zhihua , bin li , Tao Tao
Published: March 2022

Legionnaires’ disease remains a serious health problem globally, caused
by the Gram-negative bacteria Legionella. The study objective was to
characterize the ability of ozone to kill viable but non-culturable
(VBNC) Legionella and examine the kinetic characteristics of VBNC
Legionella inactivation. The removal of the living Legionella by ozone
was highest (>99%) among VBNC, living (culturable, no
including VBNC), and dead Legionella trials. Ozone can kill VBNC
Legionella at a more rapid rate than the other Legionella states. Ozone
can fragment Legionella into small DNA fragments and can damage the
Legionella cell membranes and DNA. Based on our results, the killing
process was characterized as follows. Ozone oxidizes living Legionella
to VBNC Legionella and then oxidizes VBNC Legionella to dead Legionella.
Ozone damages the dead Legionella cell membrane and enters the dead
Legionella body. Ozone decomposes dead Legionella DNA into small DNA
fragments. The VBNC Legionella inactivation kinetic process in the
wastewater was expressed mathematically. These equations can be used
widely for predicting variations of VBNC Legionella concentrations and
thus as a framework for controlling the activity of the bacteria and,
ultimately, Legionnaires’ disease.
Coagulopathy in pediatric SARS-CoV-2 infection manifested as deep vein thrombosis and pulmonary embolism.
Authors: Ioannidou Loukia , Dettoraki Athina , Noni Maria , Koukou Dimitra , Botsa Evanthia , Michos Athanasios , Spoulou Vana , Pergantou Helen , Kanaka-Gantenbein Christina
Published: March 2022

Thrombotic complications of SARS-CoV-2 have been increasingly recognized
as an important component of COVID-19 in adults; however, they have been
less evident in children. We report a case of a teenager with positive
SARS‐CoV‐2 RT–PCR and underlying prothrombotic risk factors, including
aromatase inhibitor therapy, who developed deep vein thrombosis
resulting in pulmonary embolism. Laboratory tests revealed deranged
coagulation parameters (high D-dimers and Factor VIII and low
antithrombin). The patient required intensive care and was managed with
anticoagulants, dexamethasone and antithrombin concentrate. Clinical
condition and hemostatic profile gradually improved. A review of the
available literature for similar cases is presented.
Quantum Mathematical Integrated Information Theory: From the Classical Version
Authors: Sharma Siddharth
Published: March 2022

This paper is an attempt to give a Quantum theory of Mathematical
integrated information theory which is mathematical version of
integrated information theory by Masafumi Oizumi, Larissa Albantakis,
Giulio Tononi [2]. Using the definitions of Classical Mathematical
Integrated Information Theory [1]. And considering that the Quantum
theory is given by the functor which maps from a category whose objects
is topology to a linear category whose objects are Hilbert spaces
indexed with the objects from previous category. Also, we will be using
the definition of conditional density matrix to define repertoire. We
will be also discussing the relationship between consciousness and
entanglement.
Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes
Authors: Najari-Hanjani Parisa , Najafi Rana , Akbar Soroush
Published: March 2022

The period (PER) family genes (PER1, PER2, and PER3) play a fundamental role in regulating the day/night cycle. PER3 has a pseudogene variant, PER3P1 or PER4, whose role and expression pattern is unclear in human health and diseases. This study was performed to evaluate the expression levels of normal PER family members and the PER3P1 pseudogene in colorectal cancer (CRC) and type 2 diabetes (T2D). Blood samples were taken from 50 diabetic patients and analyzed using real-time PCR for quantification of PER3 and PER3P1 expression. Colorectal tumor tissues of 50 individuals were also used to evaluate the expression of PER members. All PER members, including PER3P1, were found to be downregulated in colorectal tumor samples. Blood samples collected from diabetic subjects revealed an opposite expression pattern; both PER3 and its pseudogene were found to be upregulated when compared to the control group. Our results reveal coordination between the expression pattern of PER3P1 and normal PER family genes. Based on our findings and the pathological importance of this pseudogene, it can be suggested that PER3P1 may be one of the key regulators of the molecular clock network and PER family expression. This hypothesis needs to be confirmed by further studies.
The Impact of Domain-Specific Internal Audit Education on Financial Reporting Quality and External Audit Efficiency
Authors: Calvin Christopher G. , Holt Matthew
Published: March 2022

SYNOPSIS

We investigate how the geographic distribution of domain-specific internal audit education impacts financial reporting quality and audit efficiency in the U.S. Using universities with Centers for Internal Auditing Excellence as proxies for robust internal audit education, we find that companies headquartered in close proximity to these programs have fewer material weaknesses in internal controls over financial reporting, fewer financial statement misstatements, and shorter audit lags, and sometimes pay lower audit fees compared with a matched sample of companies not in close proximity to these programs. These findings have implications for practitioners responsible for the staffing and quality of their internal audit functions, the Institute of Internal Auditors in its education-collaboration initiatives, and higher-learning institutions responsible for educating future audit practitioners. These findings also contribute to the academic debate on the value of internal audit and determinants of internal audit function quality.

Data Availability: Data are available from sources cited in the text.
Analisis Nilai Keteladanan dalam Teks Biografi pada BSE Bahasa Indonesia Kelas X SMA Tahun Pelajaran 2020/2021
Authors: Farhanah Nurul , Safi'i Imam
Published: March 2022

Artikel bertujuan untuk mendeskripsikan nilai keteladanan yang terdapat dalam teks biografi pada buku sekolah elektronik (BSE) Bahasa Indonesia SMA kelas X tahun pelajaran 2020/2021. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Data yang digali dalam penelitian ini adalah nilai keteladanan yang terdapat dalam teks biografi pada buku BSE bahasa Indonesia kelas X SMA. Berdasarkan penelitian yang telah dilakukan, diperoleh sejumlah data yaitu dalam teks biografi pada buku BSE bahasa Indonesia  kelas X SMA terdapat beberapa nilai keteladanan, yaitu berupa ketabahan, berpendirian teguh, bekerja keras, bertekad kuat, rendah hati, ulet, profesional dan disiplin waktu, tekun belajar, keberanian, cerdas, dan bersikap kritis. Hasil penelitian menunjukkan teks biografi yang dimuat dalam BSE Bahasa Indonesia kelas X SMA berkualitas baikKata Kunci: Nilai Keteladanan; Teks Biografi.
Pengaruh Perhatian Orang Tua dalam Pembelajaran Online Matematika Terhadap Motivasi Belajar Siswa
Authors: Harefa Selvina , Yasifati Hia
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh perhatian orang tua dalam pembelajaran online matematika terhadap motivasi belajar siswa di kelas VIII SMP Negeri 7 Medan. Metode kuantitatif digunakan dalam penelitian ini. Jenis penelitian yang dipakai adalahexpost facto, dengan teknik pengambilan sampel secara simple random sampling. Penentuan jumlah sampel menggunakan rumus Isaac dan Michael dengan  sampel sebanyak 162 siswa kelas VIII SMP Negeri 7 Medan. Hasil analisis linier sederhana, menunjukkan terdapat pengaruh signifikan antara perhatian orang tua terhadap motivasi belajar siswa diperoleh Y = 5.284 + 1.097X. Hasil uji hipotesis menggunakan uji t pada taraf signifikan 95% dan alpha 5% diperoleh nilai thitung sebesar 25.957 dan ttabel sebesar 1.975 dengan demikian thitung> ttabel atau 25.957 > 1.975 sehingga hipotesis diterima. Koefisien determinasi (R2) adalah 0,808 yang menjelaskan pengaruh perhatian orang tua dalam pembelajaran online terhadap motivasi belajar Matematika siswa sebesar 80,8% sedangkan 19,2% dipengaruhi variabel lain diluar penelitian. Sehingga disimpulkan bahwa  terdapat pengaruh yang signifikan antara perhatian orang tua terhadap motivasi belajar siswa.
Pemanfaatan Situs Sejarah di Ternate Sebagai Sumber Pembelajaran
Authors: Safi Jamin , Bau Suharlin Ode
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan situs sejarah di Ternate sebagai sumber pembelajaran. Untuk mencapai tujuan tersebut, maka dalam penelitian ini digunakan metode penelitian kualitatif. Penelitian ini bersifat penelitian lapangan. Pengumpulan data dilakukan dengan cara wawancara, pengamatan dan analisis isi. Validitas data dilakukan dengan cara triangulasi untuk memperoleh informasi yang akurat. Pembelajaran sejarah pada mata kuliah kajian peninggalan sejarah dilakukan dengan mengeksplorasi peninggalan sejarah di Ternate. Eksplorasi peninggalan sejarah dilakukan setelah mahasiswa memperoleh pengetahuan dari dosen. Pembelajaran lapangan dilakukan dengan metode project dan wisata ilmiah. Proses pembelajaran lapangan mengukuti skema pemanfaatan situs sejarah di Ternate sebagai sumber pembelajaran yang meliputi orientasi pembelajaran; eksplorasi situs sejarah; dan penulisan laporan dan presentasi hasil. Dalam kegiatan eksplorasi, mahasiswa mengamati, mencatat, dan menafsirkan situs-situs peninggalan sejarah. Pembelajaran lapangan dapat mendorong mahasiswa untuk berpikir kronologis pada setiap peristiwa sejarah. Kajian peninggalan sejarah juga dapat menumbuhkan kesadaran sejarah pada mahasiswa.
Improving Students' Listening Ability Using Edpuzzle Interactive Video
Authors: Mawaddah Nadrotin , Mustofa Mutmainnah , Putra Irfan Susiyana
Published: March 2022

The problems faced by the students in this listening class were identified as the difficulty of recalling memory and managing concentration during listening. Therefore, this classroom action research solution is Edpuzzle interactive video because the teacher can easily embed questions, notes, and recording voices into the video. When students play the video until it reaches a particular minute of the timeline, it will automatically pause, and a question will appear. This study revealed that this media could increase the students' listening skills. The students were more motivated to listen using Edpuzzle because they liked the "rewatch" feature and the automatic feedback. The teacher's role in presenting a clear tutorial and directing the listening process is crucial to the success of this research. Moreover, the teacher paid more attention to the content of the video and the complexity of the questions adjusted to the students' listening ability level.
Management accunting its constraints
Authors: Ghodrati Zoeram Abbas , Ansari Vali , Dehghan Khalil
Published: March 2022

The organizational transformation that happened in the world economy recent decade was accompanied by the concepts of less-profitable production and flexible system. The concepts implicitly provide a production and working capacity that is consistent with demand and current capacity of acceptance. The origin of limited management was higher according to efficiency and imbalance between resources and demand for the resources. There are double restrictions for the private institutions and in all Irish economic fields. Methodology: The international institutions face with the global limitations about less-profitable productive models. The non-commercial institutes are facing new problems that are related to the lack of employees and other resources while there were a recession and low efficiency about resources. Goldratt in her book providing theories about constrains provides new fields in economic perspective (Goldratt and Cooks, 1993). These managing ideas of best salesman are describing as an exciting story that describes the manager’s attempts to prevent the loss caused by performance and the bankruptcy of the company. Results: In the story, Goldratt and Descooks attacked to the price finished accounting as an “enemy to productivity” rather than using developed holistic techniques as on-time production and statistic control of the process. In this article, the relative usefulness of the theory of constraints related to accounting business managing methods is explained to use the resources and decision-making. Conclusion: The article, also examines the spread and evaluation of constrains and reactions that cause accounting and managing culture. Survival of the price finished management that is explaining against the continuous attacks is consistent with the probabilities by Goldratt relating to regulations ability to make changes and obligatory developments as training programs.
The mediating effect of profitability in the relationship between Intellectual Capital and Market value
Authors: Jafaridehkordi Hamidreza , Motalebian Chaleshtori Mojtaba , Aminiandehkordi Parasto
Published: March 2022

The purpose of this study is to investigate empirically the mediating effect of profitability in the relationship between intellectual ‎capital and market value of companies listed in Bursa Malaysia for the period 2006-2011. This research wanted to establish the mediating effect of profitability on the relationship between intellectual capital and market value through panel data and the Generalized Method of Moments (GMM) model in a longitudinal design. Methodology: In doing so, it applied Pulic’s Value Added Intellectual ‎Coefficient (VAIC™) method as the efficiency measure for measuring intellectual capital. In addition, Sobel’s z-value, Aroian test, Goodman test, and Kenny and Boran approach which were used for testing the hypotheses for quantitative data was drawn from Malaysian listed companies. Results: Profitability is a significant mediator (partial mediator) in the association between the intellectual capital and market value of the companies and increases the relationship between the two variables by 41.8 percent.  Conclusion: This is the first study that shows the mediating effect of profitability in the relationship between the intellectual ‎capital and market value of the companies in Malaysia.
ExecProject: uma ferramenta educacional para a simulação da execução de projetos
Authors: Petri Giani , Silva José Gilberto Molina da
Published: March 2022

Tecnologias educacionais têm sido inseridas em sala de aula com o objetivo de desenvolver competências e motivar os estudantes. Em cursos de graduação em computação, guias de currículo recomendam o uso de ferramentas para o ensino prático de gerência de projetos. No entanto, na prática, o uso de tecnologias educacionais no ensino de GP em cursos de computação ainda é restrito, principalmente, devido a limitação das ferramentas na abrangência dos conteúdos. Diante disso, o objetivo deste artigo é apresentar o desenvolvimento e avaliação de uma ferramenta educacional (ExecProject) para a simulação da execução de projetos. Resultados de uma avaliação envolvendo 17 alunos indicam que a ExecProject possui uma boa usabilidade (score escala SUS = 75.15), é de fácil utilização e, do ponto de vista dos alunos, contribui para aprendizagem e compreensão da execução de projetos e suas interferências. Resultados deste artigo podem auxiliar professores na adoção de tecnologias e, assim, contribuir para a aplicação prática de GP na formação de estudantes de computação
Predictive value of metabolic parameters of baseline 18F-fluorodeoxyglucose positron emission tomography/computed tomography for survival rates of children with lymphoma (a metaanalysis and literature review)
Authors: Likar Yu. N. , Yadgarov M. Ya. , Myakova N. V.
Published: March 2022

The five-year overall survival (OS) rate for pediatric Hodgkin's (HL) and non-Hodgkin's (NHL) lymphomas remains at 85–95% despite improvements in therapy regimens. The problem of establishing reliable prognostic factors that could help identify high- or ultra-high-risk patients is still unresolved. We performed a systematic literature review and meta-analysis of studies investigating the predictive value of baseline metabolic parameters of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in pediatric patients with lymphomas. We systematically searched the following databases: PubMed, Medline, Cochrane Library and Google Scholar. Six retrospective studies (309 patients) evaluating the effect of quantitative parameters derived from baseline PET/CT with 18F-FDG (maximum standardized uptake value (SUVmax), tumor metabolic volume (MTV), and total lesion glycolysis (TLG)) on OS and event-free survival (EFS) in children with HL and NHL were included in our analysis. We used the Cochrane ROBINS-I tool to assess the quality of studies; the relative risks (RR) for the studied outcomes were calculated with RevMan software, version 5.3. The overall analysis showed that high MTV was associated with a six-fold increase in the relative mortality risk (RR 6.18 (3.15–12.11), p < 0.001) and a more than 5-fold increase in the risk of relapse/progression (RR 5.68 (3.21–10.07), p < 0.001). High values of TLG were associated with an eight-fold increase in the risk of mortality (RR 8.06 (3.35–19.39), p < 0.001) and worse EFS (RR 5.75 (2.99–11.06), p < 0.001). Our results will enable oncologists to expand existing risk assessment systems and improve their predictive effectiveness by using MTV and TLG parameters.
An optimization model for the fair distribution of prize money in ATP tournaments
Authors: Govea Zureneth , Pérez-Galarce Francisco , Candia-Véjar Alfredo
Published: March 2022

The Association of Tennis Professionals (ATP) distributes a considerable amount of money in prizes each year. Studies have shown that only the top 100 ranked players can self-finance; hence, it is convenient to introduce changes to the prize distribution to promote a more sustainable system. A Linear Programming model to distribute the tournament’s budget under a new concept for the fair distribution of prize money is proposed. Additionally, to distribute the prizes, a function based on the effort of the players is designed. The model was applied to tournaments to demonstrate the impact on improving the player’s prizes distribution.
Experimental Study of the Effect for Water Depth on the Mass Transfer of Passive Solar Still Chemical Solutions
Authors: Abed Fayadh M. , Mahmood Dalaf Shaker
Published: March 2022

An experimental study on a passive solar distiller in the Tikrit city on (latitude line"34 36onorth, longitude line "45 43o east), and purpose of that study to raise the efficiency andproductivity of the solar distiller. And then design the monoclinic solar distiller and add reflectorplate and a solar concentrate. The Practical tests were conducted at a rate of every half-hourfrom the beginning of February to the beginning of the month of June. The study began bycomparing the solar distiller that contain the concentrates and without contain it. Then study theinfluence of adding coal and chemical solutions, like blue Thymol solution and bluebromophenol solution to see the additions effect on the productivity and efficiency of distiller,and also The study was conducted to see the effect of the water depth on the productivity ofdistiller with take four water depths within the basin are (2,1.5,1,0.5) cm of water. The tests wereconducted in weather conditions close. and the results of the study, That distilled added hisconcentrates improved its productivity by 46% and efficiency increases 43% with non-use ofconcentrates, and coal increased efficiency by 36% and productivity improved up to 38%, theaddition of blue Thymol solution increases the efficiency by 19% and productivity by 16%, aswell as bromophenol solution increase productivity by 23% and improve efficiency by 25%,when comparing the additions found that the best one is coal. Through the study of the depth ofthe water show that increases productivity and efficiency by reducing the depth of the water inthe basin distiller.
PENGABDIAN MASYARAKAT DALAM UPAYA PENCEGAHAN RISIKO COVID-19 DI PUSKESMAS SIWALANKERTO
Authors: Mutyah Diyan , Rustam Muh Zul Azhri , Sustrami Dya , Kirana Sukma Ayu Candra , Nurlela Lela , Prasetyo Taufan Agung , Riestiyowati Maya Ayu
Published: March 2022

Penularan Covid-19 sangat mudah terjadi, hanya melalui percikan cairan yang tidak terlihat dari mulut atau hidung, permukaan benda yang terkontaminasi virus corona yang tersentuh oleh tangan kemudian tangan tersebut menyentuh area wajah, dan melalui udara terutama pada ruangan tertutup atau ventilasi buruk. Adapun upaya pencegahan risiko penularan dengan menerapkan protokol kesehatan pencegahan covid 19 yang ketat. Tujuan kegiatan ini memberikan pemahaman tentang upaya pencegehan resiko penularan covid 19 pada masyarakat di wilayah kerja puskesmas Siwalankerto. Metode yang digunakan berupa pendidikan kesehatan tentang upaya pencegahan risiko penularan covid 19 di puskesmas Siwankerto. Hasil pengabdian masyarakat ini berupa gambaran karakteristik sebagian besar pada responden perempuan dengan rata-rata usia 34 tahun, dan pada kelompok usia 20-31 tahun serta bekerja sebagai tenaga kesehatan. Sedangkan untuk terdapat juga mayoritas pada responden perempuan berusi 20-21 tahun dengan tingkat imunitas yang baik, dan risiko beraktifitas di luar rumah juga memiliki risiko rendah, serta risiko penularan di dalam rumah juga memiliki risiko yang rendah terutama saat pelayanan kesehatan di Puskesmas Siwalankerto ini agar dapat ditingkatkan tentang protokol kesehatan yang telah dijalankan disertai dengan edukasi berupa media poster yang lebih menarik sehingga mudah dipahami oleh pengunjungan yang ingin berobat.
PENGGUNAAN SOSIAL MEDIA SEBAGAI UPAYA UNTUK MEMAKSIMALKAN PEMASARAN HASIL UMKM KERIPIK TEMPE DI DESA KAMBENG KECAMATAN SLAHUNG
Authors: Mirnawati Mirnawati , Amri Muhtadin
Published: March 2022

Perekonomian Indonesia tidak bisa dijauhkan dari peran besar UMKM yang senantiasa tumbuh dengan berbagai jenis produk baik barang maupun jasa. KPM-DDR yang dilaksanakan di Desa Kambeng, Kecamatan Selahung memilih melakukan pengamatan usaha keripik tempe yang dijalankan oleh seorang wanita berusia lanjut. Usaha ini sudah dijalankan selama bertahun-tahun, namun usahanya belum terlihat ada perkembangan baik dalam hal inovasi barang maupun pemasaran. KPM DDR  ini menggunakan pendekatan ABCD (Asset Based Community Development), dengan melakukan langkah yaitu inkulturasi, discovery, design, define and reflection. Strategi yang digunakan dalam pemasaran diarahkan ke media sosial sebagai upaya untuk memperluas jangkauan karena saat ini mayoritas kalangan menggunakan sistem teknologi digital dalam bertransaksi.
Dynamique de la mangrove et perceptions locales dans le Département d’Oussouye (Basse-Casamance, Sénégal) entre 1972 et 2018
Authors: Diéye El Hadji Balla , Sané Tidiane , Solly Boubacar , Ba Boubacar Demba , Ndour Ngor , Sy Oumar , Thior Mamadou , Mendy Victor , Tall El Hadji Sidy Babacar , Mering Catherine , Diaw Amadou Tahirou
Published: March 2022

En Basse-Casamance, la mangrove constitue un écosystème particulier qui abrite de nombreuses ressources et reste le siège des principales activités rurales. Dans la zone d’Oussouye, cette mangrove a connu une régression importante au cours des décennies 1970 et 1980. L’étude de sa dynamique spatio-temporelle, à partir des outils de la géomatique couplés à des enquêtes de terrain, a permis d’appréhender son déclin, entre 1972 et 1994 de -42 % ; et son évolution positive de +22,44 % entre 1994-2018. Les facteurs à l’origine de la régression durant les années 70 et 80 sont principalement le déficit pluviométrique avec comme conséquences la salinisation et l’acidification des terres, et la faiblesse de la régénération naturelle. L’étude a aussi montré que les actions anthropiques telles que la coupe du bois pour diverses raisons et des racines échasses ont longtemps porté préjudice aux écosystèmes de mangrove. La reprise constatée au cours des dernières décennies est à replacer dans le contexte du retour de la pluviométrie à une situation meilleure et à la prise de conscience des populations du rôle stratégique et important de la mangrove.
Civic participation digitalisation: limitations in the digital divides ﬁeld
Authors: Gruzdeva M. A.
Published: March 2022

In Russian public discourse, digitalisation is recognised as a new global trend, which creates an environment with extensive communication possibilities and leads to the civic participation traditional practices reformatting to online. In this regard, it is relevant to study the opportunities, risks and necessary conditions for these transformations. The aim of the article is to identify the civic participation digitalisation limitations of the population, lying in the digital differences ﬁeld. Settlement, age, gender, educational and income factors of Internet accessibility, its use purposes and digital skills availability for Russian regions, including the Vologda Region as a typical region are considered. To solve the research problems, sociological methods, secondary data analysis, the system-structural and cross-tabulation analysis method were used. The results of the study conducted have made it possible to identify characteristics according to which certain population groups have a high, medium or low potential for civil society digital inclusion in terms of technical accessibility, knowledge and the Internet experience and digital services. The online citizenship format is most likely to be attractive to young and middle-aged people, working and living in cities, with secondary vocational or higher education. At the research time, no signiﬁcant gender impact and self-reported income on the digital divides was identiﬁed. However, current trends consideration in digitalisation and prolonging the older people active lives makes it possible to argue that potential participants groups in civic participation in an online format will expand in the future. The study results can be considered when planning the civil society development, taking into account current trends, developing tools to motivate different socio-demographic population groups to civic engagement online.
Erosive and ulcerative lesions of the digestive tract: optimization of diagnosis and management tactics
Authors: Osadchuk Mikhail A. , Osadchuk Alexey M.
Published: March 2022

Erosive and ulcerative lesions of the digestive tract are one of the most pressing problems in the clinic of internal diseases due to the extremely widespread prevalence, the presence of severe complications, often fatal, diagnostic difficulties due to the presence of a large number of asymptomatic pathologies and difficulties in the rational choice of therapy. Particularly noteworthy is the data that during the global pandemic of Covid-19 infection, it is capable, quite often, of causing the development of erosive and ulcerative lesions of the gastrointestinal tract. In this regard, it seems important to use drugs that can not only prevent the occurrence of erosive and ulcerative lesions and strictures throughout the gastrointestinal tract, but also effectively achieve epithelialization of injuries to the mucous membrane of the oral cavity, esophagus, stomach, small and large intestine. One of them is Rebamipid-CZ, which has a fairly high safety and efficacy profile. It seems important to consider the issues of optimizing the prevention and treatment of erosive and ulcerative lesions of various parts of the gastrointestinal tract of various etiologies, taking into account the possibility of using rebamipide both as part of complex therapy and in isolation.
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
Authors: Wróbel Marta , Cendrowski Jarosław , Szymańska Ewelina , Grębowicz-Maciukiewicz Malwina , Budick-Harmelin Noga , Macias Matylda , Szybińska Aleksandra , Mazur Michał , Kolmus Krzysztof , Goryca Krzysztof , Dąbrowska Michalina , Paziewska Agnieszka , Mikula Michał , Miączyńska Marta
Published: March 2022

Within the endolysosomal pathway in mammalian cells, ESCRT complexes facilitate degradation of proteins residing in endosomal membranes. Here, we show that mammalian ESCRT-I restricts the size of lysosomes and promotes degradation of proteins from lysosomal membranes, including MCOLN1, a Ca2+ channel protein. The altered lysosome morphology upon ESCRT-I depletion coincided with elevated expression of genes annotated to biogenesis of lysosomes due to prolonged activation of TFEB/TFE3 transcription factors. Lack of ESCRT-I also induced transcription of cholesterol biosynthesis genes, in response to inefficient delivery of cholesterol from endolysosomal compartments. Among factors that could possibly activate TFEB/TFE3 signaling upon ESCRT-I deficiency, we excluded lysosomal cholesterol accumulation and Ca2+-mediated dephosphorylation of TFEB/TFE3. However, we discovered that this activation occurs due to the inhibition of Rag GTPase–dependent mTORC1 pathway that specifically reduced phosphorylation of TFEB at S122. Constitutive activation of the Rag GTPase complex in cells lacking ESCRT-I restored S122 phosphorylation and prevented TFEB/TFE3 activation. Our results indicate that ESCRT-I deficiency evokes a homeostatic response to counteract lysosomal nutrient starvation, that is, improper supply of nutrients derived from lysosomal degradation.
Essays on the Economics of Fisheries and Climate Change
Authors:   , Mediodia Hanny John
Published: March 2022

Ocean warming due to anthropogenic climate change results in the spatial redistribution of fish and other marine species. Fish move towards higher latitudes or to deeper waters locating to areas with their desired thermal tolerances. The movement of fish in response to ocean warming affects catch, and these effects are expected to vary across geographic locations. This thesis aims to apply a production function approach to establish the relationship between sea surface temperature (SST) and catch of commercial fisheries using spatial data. The three chapters vary in terms of the area covered and the species and fishing method examined. The first chapter applies the production function approach to model catch and SST using high-resolution gridded data for yellowfin and skipjack tuna catch by purse seine in the Eastern Pacific Ocean (EPO). The results show that yellowfin and skipjack tuna catch is increasing with SST. The magnitude of the marginal product of SST varies across species, type of set, and the location of catch effort. A cross-country comparison of the relationship between SST and tuna for countries’ exclusive economic zones in the EPO is presented in the second chapter. We show that the highest marginal revenue products, when adjusted for population, are reported for countries with the highest dependency on marine resources. The third chapter is a national and subnational analysis of the relationship between SST and catch of commercial fisheries in Aotearoa New Zealand, focusing on flatfish, jack mackerel, and trevally. Our results show that catch initially increases with SST but decreases beyond a certain threshold. These essays provide relevant insights for the review of fisheries management systems in response to ocean warming.