bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology of Peripheral Artery Disease and Polyvascular Disease
Authors: Aday Aaron W. , Matsushita Kunihiro
Published: June 2021

Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide. Traditional cardiovascular risk factors, including advanced age, smoking, and diabetes, are strongly linked to an increase risk of PAD. Although PAD has been historically underappreciated compared with coronary artery disease and stroke, greater attention on PAD in recent years has led to important new epidemiological insights in the areas of thrombosis, inflammation, dyslipidemia, and microvascular disease. In addition, the concept of polyvascular disease, or clinically evident atherosclerosis in multiple arterial beds, is increasingly identified as a particularly malignant cardiovascular disease worthy of special clinical attention and further study. It is noteworthy that PAD may increase the risk of adverse outcomes in similar or even greater magnitude than coronary disease or stroke. In this review, we highlight important new advances in the epidemiology of PAD with a particular focus on polyvascular disease, emerging biomarkers, and differential risk pathways for PAD compared with other atherosclerotic diseases.
Reporting of activated partial thromboplastin time (aPTT): Could we achieve better comparability of the results?
Authors: Bronić Ana , Coen Herak Desiree , Leniček Krleža Jasna , Radišić Biljak Vanja , Krešić Branka , Milić Marija , Margetić Sandra
Published: June 2021

Activated partial thromboplastin time (aPTT) is determined and reported as clotting time in seconds aPTT(s), but it is presumed that reporting results as patient-to-normal clotting time ratio, aPTT(r), could minimize within-laboratory variability. The aim of study was to investigate differences in reporting aPTT results that can affect comparability of the results among Croatian laboratories and suggest further steps for its harmonization.
The questionnaire on aPTT reporting practice was distributed to 83 laboratories through Survey Monkey application in March 2019 as the part of the first regular round of Croatian Centre for Quality Assessment in Laboratory Medicine proficiency testing.
The survey response rate was 0.49. Majority of laboratories report aPTT results as both, seconds and ratio. Participants reported use of 23 different aPTT(s) reference intervals along with 17 different combinations of reagent/coagulometer and 25 aPTT(s) denominators of different origin for aPTT(r) calculation. Despite the same aPTT(s) results, the use of different denominators caused a dispersion of aPTT(r) results that can lead to exceeding external quality assessment performance criteria of 7%, particularly when results were compared for the same reagent group only. By applying aPTT(s) reference interval mean as denominator for calculation of aPTT(r) reference interval better concordance to harmonized one was obtained (17 vs. 27; χ2 = 3.972; P = 0.046).
In order to improve comparability of the results, laboratories are advised to use mean of aPTT(s) reference interval as denominator for aPTT(r) calculation. Type of coagulometer need to be considered when evaluating aPTT proficiency test results and its currently acceptable limit of performance evaluated accordingly.
Performance of D-dimer for predicting sepsis mortality in the intensive care unit
Authors: Han Yan-Qiu , Zhang Lei , Hu Zhi-De , Lippi Giuseppe , Li Peng , Ouyang Pei-Heng , Yan Li
Published: June 2021

The prognostic value of D-dimer (DD) in sepsis remains controversial. This study aimed to investigate the performance of DD for predicting sepsis mortality in the hospital and for identifying its potential correlates.
The clinical and laboratory data of adult sepsis patients were extracted from the Medical Information Mart for Intensive Care III (MIMIC III, v1.4) database using the structured query language (SQL). The database contains critical illness admitted to the intensive care unit at Beth Israel Deaconess Medical Center between June 2001 and October 2012. The association between DD and mortality was investigated with receiver operating characteristic (ROC) curve, restricted cubic spline and logistic regression analysis. Subgroup analysis was also used for identifying DD correlates.
The study population consisted of 358 sepsis patients. Those who died during hospital stay (N = 160) had significantly higher DD values than those who survived (N = 198). The area under the ROC curve (AUC) of DD was 0.59 (P < 0.010). In subgroup analysis, white blood cell (WBC) count > 18 x109/L and vasopressor therapy significantly decreased DD diagnostic performance. Categorical DD value was independently associated with hospital mortality after sequential organ failure score (SOFA) and blood lactate adjustment. Restricted cubic spline analysis revealed a U-shape relationship between DD and in-hospital mortality.
We conclude that the accuracy of DD for predicting in-hospital sepsis mortality depends on WBC count and vasopressor therapy. Both low and extremely elevated DD values are associated with higher risk of death.
Review of the millipede genus Hedinomorpha Verhoeff, 1934, with descriptions of three new species collected in China by Professor Jochen Martens (Diplopoda, Polydesmida, Paradoxosomatidae)
Authors: GOLOVATCH SERGEI I.
Published: June 2021

Hedinomorpha martensorum spec. nov., H. jaegeri spec. nov. and H. sympatrica spec. nov. are described, the former species from Qinghai Province, and both latter ones occurring syntopically in Shaanxi Province, China. A brief description and a new diagnosis of Hedinomorpha, a key to its 24 species presently known, and a map showing their distributions are provided. The affinities of Hedinomorpha within the tribe Sulciferini are discussed.
Statistical Seasonal Prediction of European Summer Mean Temperature Using Observational, Reanalysis, and Satellite Data
Authors: Pyrina Maria , Nonnenmacher Marcel , Wagner Sebastian , Zorita Eduardo
Published: June 2021

Statistical climate prediction has sometimes demonstrated higher accuracy than coupled dynamical forecast systems. This study tests the applicability of springtime soil moisture (SM) over Europe and sea surface temperatures (SSTs) of three North Atlantic (NA) regions as statistical predictors of European mean summer temperature (t2m). We set up two statistical-learning (SL) frameworks, based on methods commonly applied in climate research. The SL models are trained with gridded products derived from station, reanalysis, and satellite data (ERA-20C, ERA-Land, CERA, COBE2, CRU, and ESA-CCI). The predictive potential of SM anomalies in statistical forecasting had so far remained elusive. Our statistical models trained with SM achieve high summer t2m prediction skill in terms of Pearson correlation coefficient (r), with r ≥ 0.5 over central and eastern Europe. Moreover, we find that the reanalysis and satellite SM data contain similar information that can be extracted by our methods and used in fitting the forecast models. Furthermore, the predictive potential of SSTs within different areas in the NA basin was tested. The predictive power of SSTs might increase, as in our case, when specific areas are selected. Forecasts based on extratropical SSTs achieve high prediction skill over south Europe. The combined prediction, using SM and SST predictor data, results in r ≥ 0.5 over all European regions south of 50°N and east of 5°W. This is a better skill than the one achieved by other prediction schemes based on dynamical models. Our analysis highlights specific NA midlatitude regions that are more strongly connected to summer mean European temperature.
Four Ways to Improve Risk Reporting
Authors: Agarwal Ruchi , Kallapur Sanjay
Published: June 2021

Risk reporting is often unconnected with business strategy and performance, and is considered merely as a matter of compliance, which defeats the purpose of risk management. This article describes four best practices of companies that have improved their risk reporting by strengthening the vertical and horizontal communication of risks, reporting near misses, and communicating risk digitally through apps. Better risk reporting involves simplification and incentivization. It enables organizations to improve risk management and risk culture overall.
Strategies to Increase Self-, Student, and Discipline Advocacy in Adapted Physical Education
Authors: Trad Alyssa M. , R. Richards K. Andrew , Wilson Wesley J.
Published: June 2021

While sharing some characteristics with their general physical education colleagues, adapted physical educators also face unique challenges related to their role. For example, both general and adapted physical education teachers encounter stress stemming from the marginalized nature of their discipline but may navigate such experiences differently. Adapted physical education teachers often serve in itinerant roles travelling among multiple schools and may provide services for upwards of 100 students. They must also have a functional understanding of a wide variety of disabilities, individualize instruction for each student, collaborate with service providers across several schools, and be an active team member in the individualized education program process. As a result, they may need to advocate for themselves, their students, and the role of the discipline in different and unique ways. Drawing from research on general and adapted physical education teacher socialization, and available research-informed practices, the purpose of this paper is to describe the unique stressors associated with teaching adapted physical education and strategies they may implement as part of local advocacy.
Burkitt’s Thyroid Lymphoma Revealed in a Pregnant Woman With Acute Dyspnea
Authors: Masmoudi Mohamed , Hasnaoui Mehdi , Ben Abdeljalil Nouha , Belaid Takwa , Regaieg Marwa , Chebil Ezer , Mighri Khalifa
Published: June 2021

Extraganglionic Burkitt’s lymphoma is rare. Primary thyroid localization accounts for 1% to 5% of malignant tumors of the thyroid gland. The association of Burkitt’s lymphoma and pregnancy is even rarer. Our patient was pregnant at 36 weeks. She was brought to the emergency department with anterior cervical swelling, rapidly increasing in volume and becoming compressive for 15 days, in addition to dysphonia and inspiratory dyspnea. Cervical ultrasound and computed tomography scan revealed a compressive and plunging goiter. Surgery attempted after fetal extraction proved impossible due to massive tumor infiltration into adjacent structures shielding the cervical region. Accordingly, the act was limited to a glandular biopsy. The newborn was healthy. Histological examination confirmed the diagnosis of Burkitt’s lymphoma. Given the poor general condition of the patient, chemotherapy was not administered and the patient died after 15 days of stay in intensive care unit.
Grandparenting, Social Relations, and Mortality in Old Age
Authors: Jang Heejung , Tang Fengyan , Fusco Rachel A. , Engel Rafael J. , Albert Steven M.
Published: June 2021

Guided by a convoy model of social relations, this study investigates the relationships between grandparenting status, social relations, and mortality among community-dwelling grandparents age 65 and older who are caring for their grandchildren. The data were drawn from the 2008 and 2016 waves of the Health and Retirement Study ( N = 564). Latent class analysis was used to identify the social network structure based on six indicators of interpersonal relationships and activities. A series of hierarchical Weibull hazard models estimated the associations between grandparent caregiving, social relations, and mortality risk. Results of survival analyses indicate that co-parenting and custodial grandparents had higher all-cause mortality risk than grandparents who babysat occasionally; however, for custodial grandparents, the association was not significant once social relation variables were added to the model. This study suggests that community-based support may be beneficial to older grandparents and improved relationship quality is integral to the well-being of older adults.
Clinicians’ delirium treatment practice, practice change, and influences: A national online survey
Authors: Hosie Annmarie , Agar Meera , Caplan Gideon A , Draper Brian , Hedger Stephen , Rowett Debra , Tuffin Penny , Cheah Seong Leang , Phillips Jane L , Brown Linda , Sidhu Manraaj , Currow David C
Published: June 2021

Background:

Recent studies cast doubt on the net effect of antipsychotics for delirium.

Aim:

To investigate the influence of these studies and other factors on clinicians’ delirium treatment practice and practice change in palliative care and other specialties using the Theoretical Domains Framework.

Design:

Australia-wide online survey of relevant clinicians.

Setting/participants:

Registered nurses (72%), doctors (16%), nurse practitioners (6%) and pharmacists (5%) who cared for patients with delirium in diverse settings, recruited through health professionals’ organisations.

Results:

Most of the sample ( n = 475): worked in geriatrics/aged (31%) or palliative care (30%); in hospitals (64%); and saw a new patient with delirium at least weekly (61%). More (59%) reported delirium practice change since 2016, mostly by increased non-pharmacological interventions (53%). Fifty-five percent reported current antipsychotic use for delirium, primarily for patient distress (79%) and unsafe behaviour (67%). Common Theoretical Domains Framework categories of influences on respondents’ delirium practice were: emotion (54%); knowledge (53%) and physical (43%) and social (21%) opportunities. Palliative care respondents more often reported: awareness of any named key study of antipsychotics for delirium (73% vs 39%, p < 0.001); changed delirium treatment (73% vs 53%, p = 0.017); decreased pharmacological interventions (60% vs 15%, p < 0.001); off-label medication use (86% vs 51%, p < 0.001: antipsychotics 79% vs 44%, p < 0.001; benzodiazepines 61% vs 26%, p < 0.001) and emotion as an influence (82% vs 39%, p < 0.001).

Conclusion:

Clinicians’ use of antipsychotic during delirium remains common and is primarily motivated by distress and safety concerns for the patient and others nearby. Supporting clinicians to achieve evidence-based delirium practice requires further work.
Rumination Mediates the Longitudinal Associations Between Elementary-School Victimization and Adolescents’ Internalizing Problems
Authors: Peets Kätlin , Turunen Tiina , Salmivalli Christina
Published: June 2021

Identifying potential mechanisms responsible for victimized children’s maladjustment over time is a crucial step in our efforts to alleviate negative consequences of victimization. In this study, we examined whether rumination would serve as a potential mediator of the prospective links between victimization in late childhood and symptoms of depression and anxiety in adolescence. The sample included 552 Finnish students (238 boys; Mage in third grade = 9.85 years, SD = .71) who participated in a longitudinal study. Participants filled out several measures where they were asked about the frequency of different forms of victimization (in third and fourth grade), how much they ruminated about their past victimization and whether it elicited sadness and anger (in seventh grade), and the degree to which they experienced depressive and anxiety symptoms (in third and seventh grade). We found that greater frequency of victimization in elementary school led to increases in symptoms of depression and anxiety through rumination. These findings suggest that at least some victimization-related negative consequences can be minimized if we are able to help young people to stop reliving their painful memories.
To Disclose or Not to Disclose? The Influence of Consistently Disclosing and Disclosure Recipient on Perceptions of Children’s Credibility
Authors: Dykstra Victoria W. , Harvey Madison B. , Bruer Kaila C. , Price Heather L. , Evans Angela D.
Published: June 2021

With age, children become increasingly likely to make initial disclosures of transgressions, such as maltreatment, to peers. The present study examined adults’ credibility evaluations of children’s disclosures to peers across two studies. Study 1 examined credibility evaluations when children disclosed (or concealed) to a peer compared to an adult. Study 2 examined credibility ratings when children disclosed consistently or inconsistently across peer and adult interviews. Children were interviewed by a same-age peer and an adult regarding an event where an adult confederate spilled water on a laptop and broke it. In Study 1, participants heard a child interviewed by either a same-age peer or adult. In Study 2, participants heard a child interviewed by both the same-age peer and adult. In both studies, participants evaluated the child’s credibility. Children who disclosed the transgression were rated as significantly less credible than those who concealed the transgression; however, credibility ratings did not differ by whether the child was interviewed by a peer or adult (Study 1). Furthermore, children who concealed the transgression across both interviews were rated as significantly more credible than children who disclosed in both interviews or disclosed to the peer, but not the adult, interviewer (Study 2). The current study provides the first evidence that peer disclosures may hinder children’s credibility and that adults may be hesitant to believe children’s disclosures of an adult’s transgression.
Surveillance, Radicalization, and Prison Change Self-Analysis of an Ethnographic Survey Under Tension
Authors: Chantraine Gilles , Scheer David
Published: June 2021

This article is based on a sociological research, combining qualitative interviews and ethnographic observations, undertaken in “radicalization assessment units” in French prisons. We will first summarize the context of negotiating the research agreement, amidst a climate of panic on the part of political authorities who feared terrorist attacks. Then we will describe empirically the way the researchers were particular objects of surveillance on the prison grounds, in a way that was different, in its nature and unusual intensity, than the usual surveillance of other people who come into the prison. Lastly, we will show that this surveillance spreads beyond the prison walls, for example, the researchers were tailed when they left the prison. A reflexive work would explore all the ambiguities of this surveillance—from protection to control—and at the same time consider this surveillance of the researchers not as a contextual element of the study, but an object of the analysis in its own right. In doing so, this case study more broadly examines the methodological challenges of ethnography undertaken in difficult fieldwork together with a grounded theory capable of integrating into the analysis the vicissitudes and uncertainties of the research process itself.
Preparation and properties of an aromatic polyamide fibre derived from a bio-based furan acid chloride
Authors: Cao Kaikai , Liu Yufeng , Yuan Feng , Yang You , Wang Jin , Song Zhicheng , Li Zhongliang , Wu Wei , Jiang Mengjin , Yang Jun
Published: June 2021

A high-molecular-weight aromatic polyamide resin incorporating furan-rings (f-resin) was prepared by low-temperature solution polycondensation of bio-based 2,5-furandiformyl chloride and 3,4′-diaminodiphenyl ether, in N,N-dimethylacetamide. Further, an aromatic polyamide fibre containing furan-rings (f-fibre) was obtained from the fresin by dry-jet wet spinning, and its structure and properties were investigated. The prepared f-resin showed good solubility and possessed good spinnability in solution. The mechanical, heat-resistance, and flame-retardant properties of the f-fibre were found to be excellent – comparable to or exceeding those of meta-aramid fibre (m-fibre). In addition, the furan acid chloride monomer is bio-based and is derived from abundant resources, unlike petroleum-based monomers. Therefore, f-fibre has good potential and broad application prospects as an environment-friendly and sustainable high-performance material.
Characterization of the dynamic mechanical properties of sisal fiber reinforced PET composites; Effect of fiber loading and fiber surface modification
Authors: Gudayu Adane Dagnaw , Steuernagel Leif , Meiners Dieter , Gideon Rotich
Published: June 2021

Dynamic mechanical analysis (DMA) is an essential procedure for characterizing the performance of composites and effectively simulate with the real-world applications. This research work aims to characterize the dynamic mechanical (DM) properties of sisal fiber reinforced polyethylene terephthalate (PET) composites as a factor of fiber content and fiber surface modification. The effect of elevated processing temperature (>260°C) on the thermal degradation of sisal fibers is also analyzed. To study the effect of sisal fiber loading, PET composite specimens; one with 25% by weight fraction of raw sisal fiber (w/w), abbreviated as 25% RSC and the other with 40% by weight fraction (w/w) of raw sisal fiber, hereafter abbreviated as 40% RSC, were prepared by injection molding. Similarly, to analyze the impact of fiber surface modifications, PET composite samples containing 40% by weight fraction (w/w) of alkali-treated sisal, hereafter abbreviated as (40% Al-SC), and 40% by weight fraction (w/w) of a combined alkali/acetylation-treated sisal, hereafter abbreviated as (40% Al-ASC), were prepared. It was found that the fiber volume fraction and fiber surface modifications affected the DM properties of the produced composites. The improved storage module and glass transition temperature (Tg) with minimized damping has been demonstrated by increasing fiber content. With the same 40% fiber content, the composites produced from modified fibers enhanced the storage modulus and Tg values. However, with increasing temperature, the storage modulus decreased, the loss modulus increased, and the damping factor increased with composites containing higher fiber content and surface modified fibers. This indicates the low thermal stability of the sisal fiber and the interface damage at elevated temperatures.
Corporations and society
Authors: Padayachee Vishnu
Published: June 2021

This extended Review Article assesses the changing role of the corporation in history, using the 2018 book by Oxford scholar Colin Mayer entitled ‘Prosperity’ as a basis for the analysis. This is a traditional review article centred around the Mayer book, but as we end we take our argument, albeit tentatively, to other related issues, beyond the Mayer argument. The corporation may be viewed in a positive sense as a creator of wealth and ‘prosperity’ for society in general, or as in a negative sense as generating ‘prosperity’ only for the few, shareholders and executives at the expense of the many, including workers, customers and future generations. Colin Mayer’s book visits both sides of this ‘prosperity’ equation and the title of the book derives from this recognition. Our argument is that even within the limits of contemporary neo-liberal global capitalism, corporations could be a force for more sustainable and balanced economic growth, as well as for social and environmental good. This requires a clarification of its ‘purpose’ as well as changes in the composition of its decision-making structures and revised mandates of its boards and sub-committees such as its remuneration committees that often have been given the power alone to determine executive pay. But we argue (albeit only suggestively) in the final section that the nature and variety of capitalism itself may have to be addressed alongside firm level changes for the long-term good and sustainability of a more equal society. Mayer shows that since its birth in Roman times, as an agency for promoting public works and the public good, the corporation has taken on many different roles, with varying purpose. Only in the last 50 years has the Milton Friedman doctrine, that companies should have only one role, of maximizing shareholder wealth, become the dominant explanation for the purpose of the corporation. We are not confident that corporations will voluntarily move in these progressive directions, especially given the continuing stranglehold of neo-liberal globalization. A push for broader social and economic change from below through struggle may be essential.

JEL Codes: B1, N1, M14
The Hands of Time
Authors: Lewis Ariane
Published: June 2021

When making decisions about goals-of-care for a patient who lacks decision-making capacity, surrogates sometimes have internal disagreements, particularly if there are complicated family dynamics. Here, I describe the evolution of end-of-life discussions for a patient who had a catastrophic stroke amongst a family who had preexisting discord.
Assessing Mothers’ Automatic Affective and Discipline Reactions to Child Behavior in Relation to Child Abuse Risk: A Dual-Processing Investigation
Authors: Rodriguez Christina M. , Silvia Paul J. , Lee Shawna J. , Grogan-Kaylor Andrew
Published: June 2021

Given the scope and adverse clinical consequences of child abuse, assessment of salient etiological factors can lend critical insights needed for abuse prevention. Increasingly, dual-processing models have been applied to aggression, which postulate that parallel automatic and conscious processes can evoke aggressive behavior, implicating both affective and cognitive elements in both routes. Using two samples of mothers ( n = 110 and n = 195), the current investigation considered evidence of the reliability and convergent, concurrent, and construct validity of the new Automatic Parent Emotion Analog Response task relevant to parent–child aggression, contrasted with a self-reported conscious processing measure. Findings provide evidence that affective reactions of both anger and worry relate to child abuse risk and inclination to respond aggressively, and demonstrate how mothers’ automatic reactions relate to both perceived child misbehavior and child dangerous behavior. Current results lend psychometric support for automatic processing in parent–child aggression consistent with other dual-processing theories of aggression.
Troubled schools in troubled times: How COVID-19 affects educational inequalities and what measures can be taken
Authors: Frohn Julia
Published: June 2021

When discussing possible consequences of the COVID-19 pandemic, it seems certain that the effects of the pandemic will most likely magnify existing educational disparities in Europe and around the world. However, so far, little is known about how the conditions and consequences of distance learning intensify existing dynamics of educational inequalities. This paper aims at answering the question of how educational disadvantages in socially deprived settings are exacerbated through the pandemic. On this basis, it reflects on potential educational practices that can help countering these dynamics. For this study, interviews with teachers in socio-economically disadvantaged ( n = 12) and in privileged settings ( n = 4) were conducted, transcribed and investigated through qualitative data analysis. The data were categorized with reference to Pierre Bourdieu’s theory of capital to analyze and systematize the empirical results. Finally, a case study from the interview material offers options for action that can counteract a possible worsening of educational disadvantages and help (re-)think school and teaching based on the experiences gained during the lockdown.
On Modeling the Social-Psychological Foundations of Support for Donald Trump
Authors: Enders Adam M. , Uscinski Joseph E.
Published: June 2021

Scholars have identified many social-psychological factors correlated with support for Donald Trump; however, attempts at modeling these factors tend to suffer from omitted variable bias on the one hand, or multicollinearity on the other. Both issues obscure inferences. Using two nationally representative surveys, we demonstrate the perils of including or failing to include many of these factors in models of Trump support. We then reconceptualize the social-psychological sources of Trump support as components of a broader “profile” of factors that explains Trump support in 2018 and vote choice in 2016, as well as attitudes about issues connected to Trump. Moreover, this profile—an amalgamation of attitudes about, for example, racial groups, immigrants, and political correctness—rivals partisanship and ideology as predictors of Trump support and is negatively related to support for mainstream Republican candidates. Our analyses suggest that Trump benefited from activating dimensions of public opinion that transcend traditional party cleavages.
In the Name of the President
Authors: Cavari Amnon , Yoel Benjamin , Lowenkamp Hannah
Published: June 2021

Presidents often make references to their predecessors in their oral remarks—a rhetorical tool that can advance support for their policies, define their presidency, and achieve political gains. And yet, despite the frequency that this rhetorical tool is used and its possible impact, references to former presidents have so far defied a systematic empirical research. To fill in this void in the literature, we examine the frequency of references to presidents, the identity of referenced presidents, and the policy context of each reference in all oral references made by presidents Reagan through Trump. We demonstrate that mentioning former presidents is a political tool that presidents use routinely in their public speeches. We find that presidents use this tool strategically—controlling the timing and identity of references and in connection to their policy appeals.
Parametric analysis of the heat transfer behavior of the nano-particle ionic-liquid flow between concentric cylinders
Authors: Shah Rehan Ali , Ullah Hidayat , Khan Muhammad Sohail , Khan Aamir
Published: June 2021

This paper investigates the enhanced viscous behavior and heat transfer phenomenon of an unsteady two di-mensional, incompressible ionic-nano-liquid squeezing flow between two infinite parallel concentric cylinders. To analyze heat transfer ability, three different type nanoparticles such as Copper, Aluminum [Formula: see text], and Titanium oxide [Formula: see text] of volume fraction ranging from 0.1 to 0.7 nm, are added to the ionic liquid in turns. The Brinkman model of viscosity and Maxwell-Garnets model of thermal conductivity for nano particles are adopted. Further, Heat source [Formula: see text], is applied between the concentric cylinders. The physical phenomenon is transformed into a system of partial differential equations by modified Navier-Stokes equation, Poisson equation, Nernst-Plank equation, and energy equation. The system of nonlinear partial differential equations, is converted to a system of coupled ordinary differential equations by opting suitable transformations. Solution of the system of coupled ordinary differential equations is carried out by parametric continuation (PC) and BVP4c matlab based numerical methods. Effects of squeeze number ( S), volume fraction [Formula: see text], Prandtle number (Pr), Schmidt number [Formula: see text], and heat source [Formula: see text] on nano-ionicliquid flow, ions concentration distribution, heat transfer rate and other physical quantities of interest are tabulated, graphed, and discussed. It is found that [Formula: see text] and Cu as nanosolid, show almost the same enhancement in heat transfer rate for Pr = 0.2, 0.4, 0.6.
Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target
Authors: Zhou Zien , Xia Chao , Mair Grant , Delcourt Candice , Yoshimura Sohei , Liu Xiaosheng , Chen Zengai , Malavera Alejandra , Carcel Cheryl , Chen Xiaoying , Wang Xia , Al-Shahi Salman Rustam , Robinson Thompson G , Lindley Richard I , Chalmers John , Wardlaw Joanna M , Parsons Mark W , Demchuk Andrew M , Anderson Craig S
Published: June 2021

Background

We explored the influence of low-dose intravenous alteplase and intensive blood pressure lowering on outcomes of acute ischemic stroke according to status/location of vascular obstruction in participants of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).

Methods

ENCHANTED was a multicenter, quasi-factorial, randomized trial to determine efficacy and safety of low- versus standard-dose intravenous alteplase and intensive- versus guideline-recommended blood pressure lowering in acute ischemic stroke patients. In those who had baseline computed tomography or magnetic resonance imaging angiography, the degree of vascular occlusion was grouped according to being no (NVO), medium (MVO), or large (LVO). Logistic regression models were used to determine 90-day outcomes (modified Rankin scale [mRS] shift [primary], other mRS cut-scores, intracranial hemorrhage, early neurologic deterioration, and recanalization) by vascular obstruction status/site. Heterogeneity in associations for outcomes across subgroups was estimated by adding an interaction term to the models.

Results

There were 940 participants: 607 in alteplase arm only, 243 in blood pressure arm only, and 90 assigned to both arms. Compared to the NVO group, functional outcome was worse in LVO (mRS shift, adjusted OR [95% CI] 2.13 [1.56–2.90]) but comparable in MVO (1.34 [0.96–1.88]) groups. There were no differences in associations of alteplase dose or blood pressure lowering and outcomes across NVO/MVO/LVO groups (mRS shift: low versus standard alteplase dose 0.84 [0.54–1.30]/0.48 [0.25–0.91]/0.99 [0.75–2.09], Pinteraction = 0.28; intensive versus standard blood pressure lowering 1.32 [0.74–2.38]/0.78 [0.31–1.94]/1.24 [0.64–2.41], Pinteraction = 0.41), except for a borderline significant difference for intensive blood pressure lowering and increased early neurologic deterioration (0.63 [0.14–2.72]/0.17 [0.02–1.47]/2.69 [0.90–8.04], Pinteraction = 0.05).

Conclusions

Functional outcome by dose of alteplase or intensity of blood pressure lowering is not modified by vascular obstruction status/site according to analyses from ENCHANTED, although these results are compromised by low statistical power. Clinical Trial Registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01422616
“Increasing Warm Handoffs: Optimizing Community Based Referrals in Primary Care Using QI Methodology”
Authors: Sanderson Dana , Braganza Sandra , Philips Kaitlyn , Chodon Tashi , Whiskey Renee , Bernard Patrizia , Rich Andrea , Fiori Kevin
Published: June 2021

Social and environmental factors have an outsized effect on one’s health. Children are particularly impacted by the adverse effects of poverty. While social determinants of health (SDH) screening in healthcare settings has proliferated there remain gaps in best practices for screening processes. As research has shown that patient navigation leads to an improvement in unmet social needs and family-reported child health, warm handoffs may be a key factor in assuring that the social needs of families are effectively addressed. Using quality improvement (QI) methods our pediatric clinic worked to increase the warm handoff rate between Community Health Workers (CHWs) and patients with unmet social needs. CHW warm handoff rates increased two-fold over the intervention period. Our results illustrate that QI methods can be used to optimize workflows to increase warm handoffs with CHWs. This is important as health centers work to improve their social needs screening and referral programs.
Fostering Employee Trust via Effective Supervisory Communication during the COVID-19 Pandemic: Through the Lens of Motivating Language Theory
Authors: Men Linjuan Rita , Qin Yufan Sunny , Jin Jie
Published: June 2021

This study examines how supervisory leadership communication during the COVID-19 pandemic fostered employee trust through the lens of motivating language theory. Drawing insight from self-determination theory, this study also reveals the mediating effects of employees’ psychological need satisfaction for competence and relatedness in this process, which help explain how supervisory leadership communication influences employee trust. Through an online survey of 393 full-time employees from various organizations in the U.S., results showed that supervisory use of meaning-making (0.15), empathetic (0.60), and direction-giving language (0.27) during the pandemic all showed significant positive effects on employee trust toward leadership and the organization directly, and indirectly through satisfying employees’ psychological need for competence and relatedness. Theoretical and practical implications of the findings are discussed.
18S rRNA variability maps reveal three highly divergent, conserved motifs within Rotifera
Authors: Bininda-Emonds Olaf R. P.
Published: June 2021

Background

18S rRNA is a major component of the small subunit of the eukaryotic ribosome and an important phylogenetic marker for many groups, often to the point of being the only marker available for some. A core structure across eukaryotes exists for this molecule that can help to inform about its evolution in different groups. Using an alignment of 18S rDNA for Rotifera as traditionally recognized (=Bdelloidea, Monogononta, and Seisonacea, but not Acanthocephala), I fitted sequences for three exemplar species (Adineta vaga, Brachionus plicatilis, and Seison nebaliae, respectively) to the core structure and used these maps to reveal patterns of evolution for the remainder of this diverse group of microscopic animals.

Results

The obtained variability maps of the 18S rRNA molecule revealed a pattern of high diversity among the three major rotifer clades coupled with strong conservation within each of bdelloids and monogononts. A majority of individual sites (ca. 60%) were constant even across rotifers as a whole with variable sites showing only intermediate rates of evolution. Although the three structural maps each showed good agreement with the inferred core structure for eukaryotic 18S rRNA and so were highly similar to one another at the secondary and tertiary levels, the overall pattern is of three highly distinct, but conserved motifs within the group at the primary sequence level. A novel finding was that of a variably expressed deletion at the 3' end of the V3 hypervariable region among some bdelloid species that occasionally extended into and included the pseudoknot structure following this region as well as the central “square” of the 18S rRNA molecule. Compared to other groups, levels of variation and rates of evolution for 18S rRNA in Rotifera roughly matched those for Gastropoda and Acanthocephala, despite increasing evidence for the latter being a clade within Rotifera.

Conclusions

The lack of comparative data for comparable groups makes interpretation of the results (i.e., very low variation within each of the three major rotifer clades, but high variation between them) and their potential novelty difficult. However, these findings in combination with the high morphological diversity within rotifers potentially help to explain why no clear consensus has been reached to date with regard to the phylogenetic relationships among the major groups.
A novel method to identify gene interaction patterns
Authors: Lu Xinguo , Liu Fang , Miao Qiumai , Liu Ping , Gao Yan , He Keren
Published: June 2021

Background

Gene interaction patterns, including modules and motifs, can be used to identify cancer specific biomarkers and to reveal the mechanism of tumorigenesis. Most of the existing module network inferencing methods focus on gene independent functional patterns, while the studies of overlapping characteristics between modules are lacking. The objective of this study was to reveal the functional overlapping patterns in gene modules, helping elucidate the regulatory relationship between overlapping genes and communities, as well as to explore cancer formation and progression.

Results

We analyzed six cancer datasets from The Cancer Genome Atlas and obtained three kinds of gene functional modules for each cancer, including Independent-Community, Dependent-Community and Merged-Community. In the six cancers, 59(3.5%) Independent-Communities were identified, while 1631(96.5%) Dependent-Communities were acquired. Compared with Lemon-Tree and K-Means, the gene communities identified by our method were enriched in more known GO categories with lower p-values. Meanwhile, those identified distinguishing communities can significantly distinguish the survival prognostic of patients by Kaplan-Meier analysis. Furthermore, identified driver genes in the gene communities can be considered as biomarkers which can accurately distinguish the tumour or normal samples for each cancer type.

Conclusions

In all identified communities, Dependent-Communities are the majority. Our method is more effective than the other two methods which do not consider the overlapping characteristics of modules. This indicates that overlapping genes are located in different specific functional groups, and a communication bridge is established between the communities to construct a comprehensive carcinogenesis.
Routine clinical care data from thirteen cardiac outpatient clinics: design of the Cardiology Centers of the Netherlands (CCN) database
Authors: Bots Sophie H. , Siegersma Klaske R. , Onland-Moret N. Charlotte , Asselbergs Folkert W. , Somsen G. Aernout , Tulevski Igor I. , den Ruijter Hester M. , Hofstra Leonard
Published: June 2021

Background

Despite the increasing availability of clinical data due to the digitalisation of healthcare systems, data often remain inaccessible due to the diversity of data collection systems. In the Netherlands, Cardiology Centers of the Netherlands (CCN) introduced “one-stop shop” diagnostic clinics for patients suspected of cardiac disease by their general practitioner. All CCN clinics use the same data collection system and standardised protocol, creating a large regular care database. This database can be used to describe referral practices, evaluate risk factors for cardiovascular disease (CVD) in important patient subgroups, and develop prediction models for use in daily care.

Construction and content

The current database contains data on all patients who underwent a cardiac workup in one of the 13 CCN clinics between 2007 and February 2018 (n = 109,151, 51.9% women). Data were pseudonymised and contain information on anthropometrics, cardiac symptoms, risk factors, comorbidities, cardiovascular and family history, standard blood laboratory measurements, transthoracic echocardiography, electrocardiography in rest and during exercise, and medication use. Clinical follow-up is based on medical need and consisted of either a repeat visit at CCN (43.8%) or referral for an external procedure in a hospital (16.5%). Passive follow-up via linkage to national mortality registers is available for 95% of the database.

Utility and discussion

The CCN database provides a strong base for research into historically underrepresented patient groups due to the large number of patients and the lack of in- and exclusion criteria. It also enables the development of artificial intelligence-based decision support tools. Its contemporary nature allows for comparison of daily care with the current guidelines and protocols. Missing data is an inherent limitation, as the cardiologist could deviate from standardised protocols when clinically indicated.

Conclusion

The CCN database offers the opportunity to conduct research in a unique population referred from the general practitioner to the cardiologist for diagnostic workup. This, in combination with its large size, the representation of historically underrepresented patient groups and contemporary nature makes it a valuable tool for expanding our knowledge of cardiovascular diseases.

Trial registration: Not applicable.
Clinical features of NK/T-cell EBV-associated LPD manifested as gastrointestinal symptoms in patients with normal immunity: a case report and literature review
Authors: Wang Si-Zhu , Dai Ying-Huan , Zhang Jie , Lu Fang-Gen , Yan La-Mei , Wu Shan
Published: June 2021

Background

Epstein–Barr virus (EBV)-associated NK/T-cell lymphoproliferative disorder (LPD) involving the gastrointestinal tract is rarely observed in individuals with normal immunity. The atypical clinical, colonoscopic manifestations often confuse clinicians, leading to misdiagnosis and delays in the treatment.

Case presentation

Herein, we reported on a single case of a patient with gastrointestinal symptoms. Several colonoscopies showed multiple irregular ulcerations, while biopsies showed colitis with infiltration of neutrophils or lymphocytes. After 2 months follow-up, the patient was diagnosed with the extranodal NK/T-cell lymphoma, nasal type, and was treated with thalidomide. Later on, a second check was performed on his first pathological sample. Immunohistochemistry revealed EBV associated NK/T-cell LPD.

Conclusions

Multiple, multiform, and segmental gastrointestinal ulcers should be an indication for EBV infection, regardless of the presence of fever, lymphadenopathy, and hepatosplenomegaly. If EBV-associated NK/T-cell LPD is considered, serum EBV-DNA should be measured, and the tissue obtained by biopsy should be carefully analyzed for a positive expression of the EBER marker.
Association between frailty and ischemic heart disease: a systematic review and meta-analysis
Authors: Liperoti Rosa , Vetrano Davide L. , Palmer Katie , Targowski Tomasz , Cipriani Maria C. , Lo Monaco Maria R. , Giovannini Silvia , Acampora Nicola , Villani Emanuele Rocco , Bernabei Roberto , Onder Graziano ,   on behalf of ADVANTAGE JA WP4 group
Published: June 2021

Background

Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD.

Methods

We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting.

Results

Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11–23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15–24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD.

Conclusions

Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground.