Triple-negative breast cancer: current treatment strategies and factors of negative prognosis
Authors: Baranova Anna ,   Department of Radiology and Oncology, Grigoriev Institute for Medical Radiology NAMS of Ukraine, Kharkiv, Ukraine,   Department of Oncology, Kharkiv National Medical University, Kharkiv, Ukraine,   Anna Baranova, Department of Oncology Kharkiv National Medical University, Kharkiv, Ukraine. Department Radiology and Oncology Grigoriev Institute for Medical Radiology NAMS of Ukraine, Kharkiv, Ukraine. E-mail: dr.baranovaanna@gmail.com https://orcid.org/0000-0002-8215-1958, Krasnoselskyi Mykola ,   Department of Radiology and Oncology, Grigoriev Institute for Medical Radiology NAMS of Ukraine, Kharkiv, Ukraine,   Department of Oncology, Radiology and Radiation Medicine V. N. Karazin Kharkiv National University, Kharkiv, Ukraine https://orcid.org/0000-0002-2419-9910, Starikov Volodymyr ,   Department of Oncology, Kharkiv National Medical University, Kharkiv, Ukraine https://orcid.org/0000-0002-6414-9918, Kartashov Sergii ,   Department of Obstetrics, Gynecology and Oncogynecology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0001-5329-5533, Zhulkevych Igor ,   Department of Oncology, Radiology Diagnostics and Therapy and Radiation Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine https://orcid.org/0000-0002-6259-6810, Vlasenko Vadym ,   Department of Cancer Surgery, Medical Center Molecule, Kharkiv, Ukraine https://orcid.org/0000-0001-9577-8760, Oleshko Kateryna ,   Department of Obstetrics, Gynecology and Oncogynecology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0001-8199-9765, Bilodid Olga ,   Department of Obstetrics, Gynecology and Oncogynecology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0002-4680-5213, Sadchikova Marina ,   Department of Cancer Surgery, Radiation Therapy and Palliative Care, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0002-8995-2862, Vinnyk Yurii ,   Department of Cancer Surgery, Radiation Therapy and Palliative Care, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine https://orcid.org/0000-0001-6053-5910
Published: November 2022

Breast cancer is the most common cancer in women and the most common cause of death in working-age women. According to the results of immunohistochemical studies, 10�20% of cases revealed a triple-negative type of breast cancer. This subtype is characterized by significant proliferative activity and growth rate, aggressive clinical course, and early metastasis. This leads to a suspicious prognosis and, accordingly, encourages an increase of surgical treatment radicalism and aggressive systemic treatment. This review briefly analyzes existing treatment strategies for triple-negative breast cancer with a focus on surgical treatment. Surgical treatment is an integral part of complex therapy. Currently, the attention of researchers is focused not only on the radicalism of the operation, ensuring long-term survival, but also on achieving a good cosmetic result that determines the quality of life of patients. In this aspect, organ-preserving and prosthetic methods of operations are promising, the feasibility and effectiveness of which are being discussed. The relevance of choosing the optimal method of operation is evidenced by the lack of generally accepted approaches based on informative markers for the prognosis of the course of the disease. Therefore, the choice of the optimal method of surgical treatment taking into account the individual characteristics of the patient and the tumor, indications for chemotherapy, and radiation therapy remains an unresolved issue and requires further research.