bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmaceutical providing of the treatment of children with epilepsy in Ukraine and abroad
Authors: Sholoiko Natalia , Hala Liliia , Kosyachenko Kostyantyn , Hubar Myroslava
Published: September 2023

The aim: to investigate the pharmaceutical providing for the treatment of epilepsy in children in Ukraine and abroad and to conduct a marketing analysis of the domestic market of antiepileptic drugs.

Materials and methods: domestic and foreign Internet sources, medical and technological documents on a specific research topic, the regulatory and legal base of Ukraine, materials of the State Formulary of Medicines, the State Register of Medicines of Ukraine were the objects of the study. The methods of marketing analysis, graphic, documentary and analytical generalization were used.

Results: a comparative analysis of clinical protocols (France, Great Britain and Ukraine) for the treatment of epilepsy in children showed that there are only 12 INNs out of 37 INNs in the country. The analysis of the formulary lists of drugs of Great Britain and Ukraine showed that the BNFC has 32 INNs, and the domestic - 10 INNs. As of October 2022, 287 names of antiepileptic drugs are registered in Ukraine, and 164 of them are allowed in children's practice. The main producers of antiepileptic drugs are India and Ukraine. Children's drugs forms are mainly represented by tablets and capsules - more than 90%. A comparison of the lists of drugs for the treatment of epilepsy from the National List of Essential Medicines of Ukraine, BNFC, WHO Model List of Essential Medicines and WHO Model List of Essential Medicines for Children showed that out of 37 INNs, only 11 INNs are listed in all documents.

Conclusions: the results prove the need of improvement of pharmaceutical providing of epilepsy treatment in Ukraine. The nomenclature and variety of dosage forms for children's practice need to be expanded. In order to increase the economic availability of epilepsy treatment, it is advisable to update the National List of the main drugs of Ukraine and include new drugs in it, which will make it possible to purchase them at the expense of the State Budget of Ukraine
Development of a new solution for determining the solubility limit of quercetin and other poorly soluble substances in aqueous solutions using the method for determining total organic carbon
Authors: Khanina Nataliia , Georgiyants Victoriya , Khanin Vadim
Published: September 2023

Aim. Given the incompleteness of literature data on the solubility of quercetin and the importance of this physicochemical characteristic in the study of its bioavailability, there is a need to develop an alternative method for accurately quantifying the solubility limit of quercetin.

Materials and methods. The concentration of quercetin in the samples was determined by directly determining the total organic carbon. For measurements, a total organic carbon analyzer 450 TOC (METTLER TOLEDO) was used with a range of measured values of 0.05–1000 ppbC µgC/l.

Results. The exact limit of the solubility of quercetin, as a poorly soluble substance, has been established. Having previously measured the value of total organic carbon in the prepared solutions, we obtained data on the concentration of quercetin in solutions depending on the pH of the solution.

Having built a graphical dependence of the measured values of the concentration of a substance on the pH values of the studied solutions, we obtain a mathematical equation of the reliance. Using the resulting function equation, one can approximate the concentration value of a substance with a pH value of 7.0. This value will be the solubility limit of the test substance for neutral media.

Conclusions. As a result of the research, a new method was proposed for the quantitative determination of the solubility limit of a substance, with an accuracy not exceeding 5.0 %. The method is based on measuring the concentration of total carbon in acidic solutions with different pH values and subsequent approximation of the obtained dependence of the pH value equal to 7.0
Care for the Self as Government Strategy in Ecovillages
Authors: Duarte Luiz Guilherme Mafle Ferreira , Ferreira Neto João Leite
Published: September 2023

ABSTRACT Based on participant observations in two ecovillages the objective of this paper is to uncover the processes of subjectivation embedded in the care for the self in ecovillages that contribute to individual and community development. Our analysis led to the following conclusions: 1) even in different countries, care for the self and others is a government strategy of the ecovillages and had many similarities; 2) work individual issues are a crucial aspect to live in a community, and 3) the infrastructure and demography are important to understanding the processes of subjectivation in the communities. Our analysis also indicates that some level of government is crucial for helping people to take care of themselves.
Pílula do Dia Seguinte: Elaboração e Evidências Psicométricas de uma Medida
Authors: Passos Ádilo Lages Vieira , Leite Ana Amábile Gabrielle Rodrigues , Medeiros Emerson Diógenes de , Araújo Ludgleydson Fernandes de , Couto Ricardo Neves , Silva Paulo Gregório Nascimento da
Published: September 2023

RESUMO Objetivou-se elaborar a Escala de Atitudes Femininas frente à Pílula do dia Seguinte (EAFPDS), reunindo evidências preliminares de validade e precisão. Participaram 223 universitárias (Midade = 21,44; DP = 4,1; amplitude 18 a 46 anos), que foram divididas em dois grupos: sexualmente ativas (51,6%) e não ativas (48,4%). Os resultados mostraram que os itens da medida possuem estrutura bifatorial, o fator I sendo nomeado como Segurança e o fator II como Ansiedade. Os respectivos fatores apresentaram Alfas de Cronbach de 0,62 e 0,67, além de homogeneidade de 0,29 e 0,41. Concluiu-se que este instrumento apresenta evidências preliminares de validade fatorial e confiabilidade, disponibilizando uma medida no português brasileiro que permite medir adequadamente as atitudes femininas frente à pílula do dia seguinte.
“They Can Fight Their Own Fights”: Prejudice, Permissiveness, and Discrimination against Minorities
Authors: Andrade Laura Novaes , Torres Cláudio Vaz , Safdar Saba
Published: September 2023

ABSTRACT The tendency to be permissive in face of a discriminatory situation is called collusion. The present study aimed to define and characterize collusion, and identify the variables connected to it, considering the perspective of different identity groups. Participants were 31 individuals divided in seven focus groups. The analysis indicated four categories connected to collusion: a) Close Relations: valuable interactions through which individuals learn behavioral patterns that lead to permissiveness; b) Group Identity: social identities, and intergroup relations patterns; c) Situation: characteristics of the situation in which discrimination is observed; and d) Cost-Effective Balance: perception the individuals have regarding the impact of their actions on the context and the cost attached to it.
Selaginella P.Beauv. (Selaginellaceae) in the state of Maranhão, northeastern, Brazil: A floristic survey and a new record for the Cerrado domain
Authors: Fernandes Rozijane Santos , Silva Junior Wagner Ribeiro da , Ferreira Alessandro Wagner Coelho , Ottoni Felipe Polivanov , Oliveira Sirlane Santos , Pietrobom Marcio Roberto , Valdespino Iván A.
Published: September 2023

Abstract This work is a floristic study of Selaginella in Maranhão. The species survey is based on collections from fieldwork conducted between April 2006 and February 2023 and specimens from Maranhão deposited at the CCAA, HBRA, MG, and SLUI herbaria. Ten species were identified: Selaginella conduplicata, S. convoluta, S. erythropus, S. flagellata, S. gynostachya S. marginata, S. minima, S. radiata, S. simplex, and S. sulcata. We report the first record of S. gynostachya for Maranhão and the Cerrado domain in Brazil. Until now, this species was only known from areas of Amazonia. We provide a map with records, an identification key, and comments about the identification and geographic distribution of Selaginella species in Maranhão state. For the new record, we also provide photos.
Validação de conteúdo de protocolo de decanulação de pacientes adultos traqueostomizados
Authors: Côrte Margaret Mendonça Diniz da , Vicente Laélia Cristina Caseiro , Friche Amélia Augusta de Lima
Published: September 2023

RESUMO Objetivo Realizar a validação de conteúdo de um protocolo de decanulação de pacientes adultos traqueostomizados. Método Para a validação de conteúdo do protocolo elaborado por fonoaudiólogas foi utilizada a técnica Delphi. Os 11 itens do protocolo foram julgados por peritos, por meio de rodadas via e-mail e foram classificados como adequados, parcialmente adequados ou inadequados, além de fornecerem comentários e sugestões sobre cada item. Foram convidados 30 fonoaudiólogos, 30 fisioterapeutas respiratórios e 30 médicos responsáveis pelo procedimento de traqueostomia e decanulação. O percentual de concordância adotado foi ≥ 80% e o processo foi interrompido quando obtido esse percentual em todos os itens. Resultados Ao final do processo, 24 profissionais participaram da terceira rodada, sendo 46% fonoaudiólogos, 29% fisioterapeutas e 25% médicos. Após as sugestões e comentários dos peritos, dois itens foram mantidos como estavam no protocolo inicial, sete foram reformulados, seis incluídos e dois excluídos. A versão final do protocolo incluiu: identificação, ausência de secreções abundantes, características da secreção, tosse eficaz, capacidade para remover secreções, tolera o balonete desinsuflado, aptidão no processo de decanulação, nível de consciência, troca de cânula para menor calibre, ausência de infecção vigente/ ativa, deglutição espontânea e eficaz de saliva, uso de válvula de fala, aptidão à oclusão da cânula, avaliação da aptidão para decanulação e exames objetivos. Conclusão Por meio da Técnica Delphi houve a validação do conteúdo do instrumento, ocorrendo mudanças substanciais. A próxima etapa de validação do instrumento é a obtenção de evidências de validade em relação a estrutura interna.
Installation of deflector in Colider Dam to minimize the percentual of total dissolved gases
Authors: Andriolo Marcos Vinicius , Araújo Anderson Nascimento de , Fontanelli Carolina , Paranhos Cássia Silmara Aver , Politano Marcela , Dettmer Paulo Henrique Cabral
Published: September 2023

ABSTRACT During voluntary or involuntary spills, the total dissolved gas (TDG) may increase with potential of causing gas bubble disease (GBD) in affected fish. Bubbles entrained during spill events in Colider are transported by plunging jets to deep, high pressure, regions in the tailrace where dissolution is enhanced increasing TDG concentrations. The most common alternative to minimize TDG supersaturation downstream of hydropower dams is to install deflectors on the spillway face. In order to reduce TDG levels downstream of the Colider's spillway, Copel retrofitted the four spillway bays with deflectors, finalizing the construction in November 2021. The design of the deflectors were assisted with two studies. The first study comprised the development of a physical model in 1:60 scale, and other study was a numerical model based on the open-source toolbox OpenFoam.
Vulnerabilities experienced by family members/caregivers of children with chronic conditions
Authors: Milbrath Viviane Marten , Gabatz Ruth Irmgard Bärtschi , Vaz Jéssica Cardoso , Hense Tuíze Damé
Published: September 2023

Abstract The objective was to know the vulnerabilities experienced by family members/caregivers of children with a chronic. Qualitative research supported by the theoretical framework of the French philosopher Roselló Un which 15 family members/caregivers of children with chronic conditions participated in the study. The information was collected in the years 2018 and 2019 and submitted to thematic analysis. The results are presented in three themes: The disease as an expression of the vulnerability of being a child; The child’s chronic illness as a condition of vulnerability of the family member/caregiver; The support of support networks: potentialities and vulnerabilities in the daily life of children with chronic conditions and family members/caregivers. Knowing the components of vulnerability experienced by the families of children with chronic conditions is complex, as it requires analyzing and reflecting on the situations these families face, considering their peculiarities, feelings, family organization and the accessibility they have to health services. Therefore, knowledge about the context in which these families are inserted is essential to establish an adequate planning of health actions aimed at promoting their well-being.
Plataformas digitais de entrega de alimentação: condições de trabalho e riscos para a saúde
Authors: Oliveira Pamela Tamara Gomes de , Junges José Roque
Published: September 2023

Resumo O isolamento social provocado pela pandemia do covid-19 acelerou um processo que já estava em curso: a plataformização da economia. Uma das aplicações presentes nesse processo foi a distribuição de comida por motoboys, ocasionando uma transformação radical das condições de trabalho, que necessita ser investigada. O objetivo desta pesquisa foi discutir essas condições e os riscos que representam para a saúde do trabalhador. 14 entregadores de alimentos foram entrevistados, suas falas foram gravadas e transcritas para análise temática, obtendo dois principais resultados: a precarização das condições de trabalho e a vulneração da saúde. A plataforma promete independência e autonomia quanto ao trabalho, mas, ao mesmo tempo, cria insegurança, não garantindo nenhuma proteção trabalhista nem subsistência financeira estável, por não assegurar os meios para o trabalho. Por outro lado, essa precarização do trabalho produz riscos para a saúde. Essa situação demanda uma discussão sobre o amparo legal dos direitos e a proteção da saúde desses trabalhadores.
Phlebotomine sand flies (Psychodidae: Phlebotominae) in an area of canine infection caused by Leishmania infantum in the state of Amapá, eastern Amazon
Authors: Pessoa Lourdes Marina Bezerra , Pinto Engels Harmet Carvalho , Chaves Thiago Evangelista Silva , Rabelo Gabriele da Silva , Brito Adrielly Lobato , Zanini Volmir Miguel , Nunes Márcio Claudio de Lima , Viana Lúcio André
Published: September 2023

Abstract In 2017, the Brazilian State of Amapá registered the first occurrence of visceral leishmaniosis (VL) in 17 dogs in the outskirts of the capital, Macapá. Given the lack of knowledge on phlebotomines in that area, this study aimed to survey the fauna of these Diptera. Sampling was performed using CDC light traps placed at ten sampling sites. The specimens captured were Evandromyia walkeri (n=237), Nyssomyia antunesi (n=65) and Bichromomyia flaviscutellata (n=6). The phlebotomine species composition resulted in low species diversity, and none of the main vectors of the etiological agent of VL were identified in the study area.
Corporate Tax Cuts and the Decline of the Manufacturing Labor Share
Authors: Kaymak Baris , Schott Immo
Published: September 2023

We document a strong empirical connection between corporate taxation and the manufacturing labor share, both in the US and across OECD countries. Our estimates associate 30 percent to 60 percent of the observed decline in labor shares with the fall in corporate taxation. Using an equilibrium model of an industry where firms differ in their capital intensities, we show that lower corporate tax rates reduce the labor share by raising the market share of capital-intensive firms. The tax elasticity of the labor share depends on the joint distribution of labor intensities and value added at the micro level. Given the empirical distribution in the US manufacturing sector, our quantitative analysis suggests that corporate tax cuts explain a significant part of the decline in the manufacturing labor share since the 1950s. The shift away from traditionally large, labor-intensive production units raised the concentration of market shares and reduced the concentration of employment.
Development of Neuro Linguistic Programming Module for Golf Athletes: A Needs Analysis
Authors: Muniandy Mahadewan , Rasyid Nelfianty Mohd , Razak Norsilawati Abdul
Published: September 2023

The aim of the study. The sport of golf demands not just physical skills but also psychological fortitude from players. To succeed in golf, athletes must have mental strength, emotional stability, and appropriate levels of anxiety. A sound psychological training program can help improve their performance, and this is precisely why the current study aims to investigate whether a Neuro-Linguistic Programming (NLP) module would be effective in achieving this goal.

Materials and methods. To conduct the study, the researchers administered a questionnaire to 120 former and current golf athletes. The data collected from the survey was analyzed using IBM SPSS software.

Results. The results reveal that a vast majority of the respondents (86.8%) believe that creating an NLP module that focuses on psychological aspects would be advantageous. The study's findings suggest that there is a pressing need to develop an NLP module that addresses the psychological needs of golfers.

Conclusions. The results have important implications for the design and implementation of psychological training programs for athletes, indicating that an NLP module could be a valuable addition to the training regimen. Furthermore, the study highlights the potential for further research in this area to refine and optimize the NLP module's effectiveness in enhancing golfers' performance
Evaluation of Impact of ESG Rating and Environmental Performance Factors on the Level of Credit Risk and Shareholder Expectations of Companies in Carbon-Intensive Industries from BRICS Countries
Authors: Agranat Victoria
Published: September 2023

The objective of the study was to evaluate the impact of ESG ratings, environmental (E) pillar scores and environmental performance metrics of non-financial companies from BRICS countries on their credit risks (measured by credit rating) and shareholder expectations (measured by enterprise value (EV) to sales multiple). Environmental performance metrics included emission scores, water efficiency scores, environmental management team scores and the ability to cope with climate risks scores. The relevance of the study is underpinned by the limited number of research in the field for BRICS countries and contradictory conclusions in research about the strength and direction of the influence of ESG factors onthe value and financial metrics of the companies. The ordered logit regression and OLS regression models were applied for credit ratings and EV/Sales multiple respectively. The sample included 206 companies from carbon-intensive industries from Brazil, China, India, South Africa and Russia for 2018-2021. Financial and ESG metrics were taken from Refinitiv while companies' credit ratings were taken from Moody’s and S&P. The results showed that the improvements in ESG and E-scores as well as environmental performance metrics hurt companies’ credit ratings. Conversely, the improvements in ESG, E-scores and environmental performance metrics had a positive impact on EV/Sales metrics. The latter confirms the TGMT (too-much-of-a-good-thing) effect of environmental performance as equity investors expect a positive effect from climate-related actions on equity performance in the long term.
Neural differentiation on EM grids - iNeurons sample preparation for cryo-ET and CLEM v1
Authors: Capitanio Cristina
Published: September 2023

This is a protocol for differentiating AAVS1-TRE3G-NGN2 iPSCs and hESCs to iNeurons directly on EM grids for cryo-ET and cryo-CLEM. The protocol comprises the following steps: EM grids coating with Matrigel or Poly-Ornithine and Laminin; differentiation and seeding of iNeurons on EM grids; lentiviral transduction for transient expression of fluorescently-labelled proteins; plunge freezing.
Understanding the Bamasaaba Men and Masculinity in Response to the Safe Medical Male Circumcision Policy in Uganda
Authors: Omukunyi Dr Bernard
Published: September 2023

This paper uses the qualitative unstructured interviews and Focus Group Discussions (FGD) to understand how Bamasaaba men conceptualise masculinity in response to safe medical male circumcision (SMMC) in Ugandan. Results were obtained from cultural leaders, clan leaders, traditional surgeons, medical officers, 2016 initiates, focus groups and the key informant, a representative of Inzu ya Masaaba. Processing the audio recorded responses and data analysis involved transcribing, interpreting, coding, and categorising using Atlas Ti software. The results of the study suggest ambivalence. The historical and political attempts to abolish TMC have evoked resistance, with most holding firmly to TMC as the only means by which Bamasaaba boys can acquire the status of manhood. However, some men see health values in medicalised male circumcision practices and believe that medicalisation has caused positive adaptations to TMC for purposes of enhanced hygiene and safety.
Percepción de los Menores Españoles sobre el Papel de sus Padres en su Uso de Redes Sociales
Authors: Feijoo Beatriz , Sádaba Charo , López-Martínez Adela
Published: September 2023

El papel de las familias en el uso que los menores hacen de los medios ha sido tradicionalmente analizado a través de distintas estrategias de mediación parental. La investigación más reciente presta atención al impacto que tiene en estas prácticas la generalización de los medios digitales y, en particular, de los dispositivos móviles y los medios sociales. En el presente artículo se busca analizar la percepción de menores españoles entre 11 y 17 años del papel de sus padres y madres en la gestión y manejo de contenido que ellos hacen de las redes sociales (challenges, publicaciones y seguimiento a influencers, desinformación, bulos). Para ello, se planteó un estudio cualitativo mediante la celebración de 12 grupos de discusión en los que las alusiones a la familia se centraron en dos dimensiones: como fuente de información a nivel general o como fuente de restricciones ante un uso que se cree excesivo. Asimismo, los menores perciben que los grupos familiares de WhatsApp son la vía por la cual reciben más bulos. Además, explicitan la tendencia a disponer de dos perfiles en una misma red social: una cuenta pública, más abierta en la que aceptan a sus padres, y una privada, que reservan sólo para las amistades cercanas.
SAYDAM BETONUN ÖZELLİKLERİ ÜZERİNE BİR ÇALIŞMA
Authors: TOPÇU İlker Bekir , KURAL Recep
Published: September 2023

Bu çalışmada, saydam betonun fiziksel ve mekanik özelikleri, dayanıklılığı ve doğal ışığı geçirme yoğunluğu üzerinde durulup, üretiminde kullanılan malzemelerin özellikleri ve oranları, betonu üreten şirketler ve uygulama örnekleri hakkında bilgi verilmiştir. Sonuç olarak, ışık geçirme özelliğine sahip malzemeler (optik fiberler, kauçuk, cam vb.) arasında en çok tercih edilenin optik fiberler (cam optik fiber, plastik optik fiber vb.) olduğu, bunların beton içerisinde farklı yerleşimleri ve yerleşim doğrultularının, farklı lif oranlarının ve lif çaplarının, saydam betonun mekanik ve fiziksel özeliklerini etkilediği gözlenmiştir. Son on yılda yapılan araştırmaları incelediğimizde çoğunun betonun ışık geçirme özelliği üzerine olduğu, estetik açıdan yapılara katkı sağlayıcı ve enerji tüketimini azaltacağı yönünde öneriler getirildiği, fakat mekanik özellikleri üzerinde herhangi bir iyileştirme çalışmaları yapılmadığı hem geopolimer beton hem de saydam malzemelerin faydalarını birleştiren beton üretimi konusunda yeterince çalışma olmadığı görülmüştür. Bu literatür taraması ile günümüz mühendislik uygulamalarında adı çok geçen “endüstriyel atık”, “geri dönüşüm”, “sürdürülebilirlik” ve “enerji verimliliği/ekonomik” kavramları ele alınarak çevre dostu yeni bir saydam betonun tasarlanıp, üretilebileceği kanısına varılmıştır.
DERİN KARIŞTIRMA KOLONLARI İLE DESTEKLİ YOL DOLGUSUNUN ÜÇ BOYUTLU SAYISAL MODELLEMESİ: PARAMETRİK ÇALIŞMA
Authors: ÇINAR ÖZKAN Fatma Tuğçe , BOZBEY Prof. Dr. İlknur
Published: September 2023

Derin karıştırma yöntemi (DSM), doğal zeminin bağlayıcı malzemeler ile karıştırılarak zeminin yerinde iyileştirilmesi işlemidir. Bu çalışma kapsamında literatürde yer alan, Tayland’da derin karıştırma kolonları ile iyileştirilmiş yumuşak bir zemin üzerine inşa edilen dolgu ile ilgili bir makale verileri kullanılarak üç boyutlu (3D) sayısal bir model oluşturulmuştur. Oluşturulan sayısal model öncelikle makalede yer alan veriler kullanılarak doğrulanmıştır. Daha sonra bu model üzerinde parametrik bir çalışma yürütülmüştür. Bu kapsamda farklı alan değiştirme oranlarına sahip modeller oluşturulmuş ve sayısal analizler yapılmıştır. Ayrıca aynı alan değiştirme oranına sahip farklı çaptaki kolonlar kullanılması durumunda farklı dolgu yükü altında oluşan oturmalar, kolonlara ve zemine gelen gerilmeler incelenmiştir. DSM kolonları için kullanılan elastisite modülündeki değişimin iyileştirme üzerindeki etkisinin değerlendirilmesi için de analizler yapılmıştır. Analizler sonucunda alan değiştirme oranının artması ile dolguda meydana gelen düşey deplasman değerlerinin azaldığı ve aynı alan değiştirme oranına sahip modellerde meydana gelen düşey deplasmanların birbirine yakın sonuçlar verdiği görülmüştür. Dolgu yükünün artması ile kolonlara gelen düşey gerilmelerin büyük ölçüde arttığı görülmüştür. Derin karıştırma kolonlarına ait elastisite modülü değerlerinin artması ile sistemde daha az deplasman oluştuğu görülmüştür. DSM kolonları için atanan modül değerlerinin oturma değerlerini önemli seviyede etkilemesi nedeniyle, bu konu ile ilgili değerlendirmeler ve öneriler yapılmıştır.
BORU DEMETİ ISI DEĞİŞTİRİCİLERİNDE FARKLI BORU ÇAPI KULLANIMININ AKIŞ VE ISI TRANSFERİNİ İYİLEŞTİRMEYE ETKİSİ
Authors: KURU Muhammet Nasıf , ERDİNÇ Mehmet Tahir , KARASU İlyas , ÜNAL Şaban
Published: September 2023

Boru demeti ısı değiştiricilerinde, boruların içindeki akışkana çapraz yönde etrafından geçirilen başka bir akışkan ile ısı transferi gerçekleştirilir. Boru dışından çapraz yönde geçirilen akışkan çoğunlukla gaz akışkanlardır. Art arda yerleştirilen borularda, en fazla ısı transferi çoğu kez birinci boruda elde edilmektedir. Birinci borudan sonra ısı ve akış karakteristiği birbirine benzer hal almaktadır. Bu durumda, hız ve sıcaklık konturlarının tekrarlanması ile periyodik akış elde edilmiş olur. Ardışık olarak gelen borularda sınır tabakanın sürekli olarak yenilenmesini sağlamak, diğer borularda birinci borudaki gibi yüksek ısı transferi elde edilmesine imkân tanıyacaktır. Isı transferi iyileştirilirken en önemli sorun basınç düşümünün de artmasıdır. Bu çalışmada düzgün sıralı dizilişe sahip boru demetinde, art arda yerleştirilen dört farklı çaptaki borular kullanılarak, ısı transferinin arttırılması ve basınç düşümünün azaltılması amaçlarıyla sayısal optimizasyon yapılmıştır. Karşılaştırmalar, ısı transferi yüzey alanının sabit, borular arasındaki boyuna ve enine mesafelerin aynı olduğu varsayılarak yapılmıştır. Düzgün sıralı dizilişe sahip boru demetinde ardışık olarak yerleştirilen dört adet borunun çaplarının D_1=5 mm,D_2=15 mm,D_3=6 mm,D_4=14 mm olması durumunda ısı transferi %14.5 oranında artarken, basınç düşümü de %377 oranında artmıştır.
SİVAS İLİ TARIMSAL ATIKLARININ BİYOKÜTLE ENERJİSİ POTANSİYELİNİN BELİRLENMESİ VE SAYISAL HARİTALARININ OLUŞTURULMASI
Authors: POLAT BULUT Ayben
Published: September 2023

Enerji, insanoğlunun hayatını devam ettirebilmesi için gerekli olan zorunlu ihtiyaçlardan biridir. Ancak günümüzdeki hızlı kentleşme, sanayileşme ve nüfus artışıyla birlikte mevcut enerji kaynakları gün geçtikçe azalmaktadır. Bu nedenle, biyokütle enerjisi de son dönemlerde dikkat çeken sürdürülebilir ve yenilenebilir enerji kaynaklarından biri olmuştur. Biyokütle enerjisi tarımsal, hayvansal, ormansal ve kentsel atıklardan elde edilen yenilenebilir, temiz, çevre dostu ve ekonomik bir enerji kaynağıdır. Bu çalışmada 2022 yılında Sivas ili için tarımsal atıklardan elde edilebilecek elde edilebilir enerji potansiyeli (EEP) TUIK verileri kullanılarak hesaplanmış ve ArcGIS programı kullanılarak hazırlanan sayısal haritalar ile sunulmuştur. Tarımsal atıklardan Sivas ili için toplam 4017 TJ EEP’ nin temin edilebileceği bu enerji ile de Sivas’ ın nüfusunun % 48’ inin enerji ihtiyacının karşılanabileceği belirlenmiştir. Tarımsal atıklardan temin edilen en yüksek EEP’ ye sahip ilçenin Şarkışla olduğu görülmüştür. Tarımsal atık kaynaklı biyokütleden üretilen enerji ile Sivas’ ın enerji ihtiyacının % 70’ inden fazlasının karşılanabileceği belirlenmiştir. Sivas’ ta üretilen tarımsal ürünler arasında EEP’ ye % 33 ile en büyük katkıya ise buğdayın sahip olduğu görülmüştür
MADENLERİN SINIFLANDIRILMASINA YÖNELİK HİBRİD BİR CNN MODELİN OLUŞTURULMASI
Authors: SELÇUK Turab
Published: September 2023

Madenlerin ülkelerin ekonomisindeki yeri oldukça büyüktür. Bu nedenle madencilikte cevher yataklarının tespiti ve tanımlanması önemli bir araştırma konusudur. Cevher sınıflandırılması işlemlerinde de bilgisayar tabanlı karar destek sistemleri kullanılmaktadır Bu çalışmada yedi farklı cevherin sınıflandırılmasına yönelik dört aşamadan oluşan hibrid bir CNN model oluşturulmuştur. Bu aşamalar, özellik çıkarımı, özellik birleştirme, özellik seçimi ve sınıflandırmadır. Özellik çıkarımı için, sınıflandırma problemlerinde yüksek başarım gösteren ResNet50, MobileNetV2 ve DenseNet201 mimarileri kullanılmıştır. Çıkarılan özellikler birleştirilerek 1x3000 boyutlarında kapsamlı özellik vektörü elde edilmiştir. Sınıflandırma başarımını arttırmak için özellik vektörüne NCA, ReliefF ve mRMR algoritmaları uygulanarak ayırt ediciliği yüksek özellikler belirlenmiştir. Bu özellikler destek vektör makineleri ile sınıflandırılmıştır. Elde edilen sonuçlara göre MRMR için 91.34, NCA için 92.42 ve ReliefF için 93,14 doğruluk değeri göstermiştir. Sonuç olarak önerilen hibrid CNN modelinin cevher sınıflandırılmasında literatürdeki klasik CNN modellere göre daha yüksek başarım sağlamıştır. Önerilen hibrid CNN modelin jeoloji alanında cevher sınıflandırılmasına yönelik çalışmalarda araştırmacılara karar desteği sağlayacağı düşünülmektedir.
Current insights into the role of miRNA-125 in cardiovascular disease: potential biological markers and therapeutic targets
Authors: Alieva Amina M. , Teplova Natalia V. , Reznik Elena V. , Baikova Irina E. , Akhmedova Madina F. , Butenko Alexey V. , Balagova Bela Z. , Modestova Anna V. , Kotikova Irina A. , Valiev Ramiz K. , Nikitin Igor G.
Published: September 2023

Recently, miRNAs are being used as diagnostic markers for various pathological conditions. This review analyzed the main studies devoted to the role of miRNA-125 in the development of cardiovascular diseases. Members of the miRNA-125 family are involved in cell differentiation, proliferation, and apoptosis by targeting mRNAs associated with these cellular processes. This miRNA can enhance or inhibit pathological processes such as oncogenesis, muscle abnormalities, neurological disorders, and others. Members of the miRNA-125 family also influence the development and function of immune cells and are involved in immunological defense. Research shows that the miRNA-125 family is associated with cardiac development. They also play an important role in pathophysiological conditions of the cardiovascular system. However, the same miRNA-125 family members play different roles in different pathological processes. For example, miRNA-125b overexpression in cardiomyocytes can inhibit their apoptosis and inflammatory response. However, miRNA-125b is also a regulator of cardiac fibrosis; its overexpression in cardiac fibroblasts can enhance their proliferation. Therefore, in pathological conditions, miRNA-125b excess aggravates myocardial fibrosis and remodeling, destroys the original morphological structure of the heart, disrupts neovascularization processes, and aggravates apoptosis of cardiomyocytes in the damaged area. Thus, to avoid adverse reactions, the optimal dose and timing of therapeutic intervention using members of the miRNA-125 family, their inhibitors, and mimetics must be carefully determined. An expanded and accurate understanding of miRNA-125 functions in gene regulatory networks associated with cardiovascular pathology will enable the development of novel and innovative therapeutic strategies.
Substantiation of the method of local deep hypothermia for the relief of synovitis of the knee joint in patients with osteoarthritis
Authors: Tereshenkov Vasily P. , Shevelev Oleg A. , Zagorodniy Nikolay V. , Khodorovich Nadezhda A. , Akhpashev Alexander A.
Published: September 2023

BACKGROUND: In patients with osteoarthritis, the long course of synovitis changes the nature of the inflammatory process, it becomes more resistant and resistant to a number of therapeutic techniques. In the arsenal of a practicing doctor, there are no reliable and affordable therapeutic methods that reliably provide relief of synovitis in the knee joint and objectively monitor the effectiveness of the therapy. Among the numerous methods of application in the treatment of diseases and injuries of the musculoskeletal system, low-molecular technologies with anti-inflammatory and analgesic effects are distinguished. One of these methods is local deep hypothermia. AIM: To substantiate the use of different low-temperature modes of local deep hypothermia in patients with knee osteoarthritis aggravated by synovitis, to study clinical efficacy and safety. MATERIALS AND METHODS: The study included 90 patients with osteoarthritis of the knee joints, burdened with synovitis. To determine the therapeutic parameters of local deep hypothermia, all patients were divided into three groups of 30 people. The effectiveness of the performed local deep hypothermia was assessed by the dynamics of the algofunctional Leken index, the intensity of joint pain on a 100-point Visual Analogue Scale (VAS) in millimeters and a decrease in the need for nonsteroidal anti-inflammatory drugs (NSAIDs). RESULTS: Technical and clinical parameters have been developed for carrying out the local deep hypothermia technique: area, cooling depth, rate of heat removal from the joint, duration of reproduction and number of procedures. Against the background of the performed local deep hypothermia, patients in three groups showed significant positive dynamics on the VAS and algofunctional Leken index, and in all three groups the difference between the initial and final values of these parameters was statistically significant (p 0.001). The use of local deep hypothermia allowed a significant part of patients to refuse to take NSAIDs, or to reduce the need to 50 mg and take episodically according to need. In our study, we did not record a recurrence of synovitis in all three groups during the first 3 months, which was 100%. After 12 months, the duration of remission in group I was 10.0%, in group II patients 73.3% and in group III patients 86.6%. CONCLUSION: Local deep hypothermia improves the effectiveness of synovitis treatment and can be recommended as an independent method for the treatment of patients with osteoarthritis of the knee aggravated by synovitis. The recommended local deep hypothermia exposure is 90 min, which allows for the longest period of remission of synovitis in the knee joint.
The IDA Very Long Period and Very Broadband Networks
Authors: Davis Peter , Berger Jon , Mellors Robert , Ebeling Carl , Auerbach Daniel
Published: September 2023

This article describes the rich global digital seismic data set that has been collected from 1975 to the present using a variety of instruments and progressively updated equipment and communication systems. The original IDA very long period (VLP) network operated from 1975 to 1995. The successor IRIS/IDA very broadband network began in 1986 and continues to the present. Collection of these data has supported advances in our understanding of the structure of the Earth’s deep interior and of the long wavelength heterogeneous structure of the mantle; the detailed behavior of large earthquakes; and the discovery of nontraditional seismic sources such as slow earthquakes, glaciers, and landslides. Near-real-time transmission of the data to hazard warning centers has expanded the network’s usefulness as a tool for rapid response to earthquakes, warning to communities affected by tsunamis, and for monitoring compliance with nuclear test ban treaties.
Astroturismo en Galicia: conservación y divulgación del cielo nocturno y oportunidad de negocio
Authors: Rodríguez Casas Marta
Published: September 2023

El astroturismo en Galicia.
The biofilm conundrum in orthodontics: Investigating the role of the bonding procedure
Authors: Gupta Ekta , Srivastava Sparsh , Asarsa Shekhar K. , Sethi Shubhita , Shul Dnyanesh , Singh Vinit Kumar
Published: September 2023

This article explores the conundrum of biofilm formation in orthodontics, its impact on oral health, and the role of the bonding procedure. Biofilms are resilient structures formed through stages like attachment, adhesion, growth, and maturation, with the extracellular matrix (EPS) playing a vital role. The bonding procedure unintentionally creates surfaces where bacteria thrive, leading to biofilm development. Factors like oral hygiene, diet, and bracket design influence biofilm formation. Maintaining oral hygiene during orthodontic treatment can be challenging due to food trapping and cleaning difficulties. Strategies to minimize biofilms involve patient education, improved bonding techniques, and antimicrobial agents. Biofilms can lead to dental decay, gingivitis, periodontitis, and white spot lesions. Combating biofilms requires collaboration, patient education, and ongoing research. Improved management can lead to better oral health outcomes for orthodontic patients.
CBCT: The third eye in orthodontics
Authors: Kabbinahalli Devjith S , Shetty Priyalakshmi , Raghava Siddharth , Shetty Praveena
Published: September 2023

Accurate diagnostic imaging is essential to derive the correct diagnosis and treatment plan in orthodontics. In two-dimensional diagnosis, geometric distortion, superimposition of structures, projective displacements, and rotational errors are common. This case series, affirming that the CBCT is vital key in the diagnosis of some specific orthodontic conditions, and presenting five case reports which was difficult to diagnose it with two-dimensional radiograph. Case 1 includes horizontally impacted 21 with crown located labially, and root palatally with close proximity to nasopalatine canal, which was veiled in 2D orthopantomogram. Case 2 is an infrazygomatic implant case, the placement of which was debatable by seeing through the 2D IOPA radiograph. Here, CBCT removed the black curtain and proved its monarchy. Case 3 is a premolar impaction, which in 2D radiograph appeared like an iceberg, but its true anatomy was revealed by the CBCT. After this, the next case 4 is about the central incisor mimicking a canine in 2D radiograph, which was found to be supernumerary tooth on CBCT. Followed by temporomandibular disorder (5) which severity was brought to light by CBCT. The need for this case series is to wave the flag for CBCT in the orthodontic diagnosis which will help in delivering proper treatment plan and emphasis where it is essential to do CBCT.
Topographic study of antral teeth on computed tomography in a beninese population
Authors: Pognon Sylvie Arlette Bancole , Diatta Mamadou , Ndiaye Mamadou Lamine , Akanni Mohamed Djivede , Tamba Babacar , Avakoudjo Francois , Ahouansou Patricia Yekpe , Dia Tine Soukeye , Adjibabi Wassi
Published: September 2023

The topographical relationships between the root tips and the floor of the maxillary sinus favour the occurrence of odontogenic maxillary sinus pathologies. Knowledge of these relationships may help to prevent such pathologies. The aim of this study was to investigate the anatomical relationships between the maxillary sinuses and the apices of the maxillary roots in a Beninese population using computed tomography (CT) images of the maxilla.

: This was a descriptive study of CT scans of facial masses performed between January 2020 and January 2023 in subjects aged at least 18 years without tumour or traumatic sinus pathology. The CT images were in Dicom format. Horos, Excel and SPSS software were used for data collection, entry and analysis.

: Of the 346 CT scans collected, 255 were included in the analysis. The mean age of the subjects was 42.65±16.57 years and the sex ratio was 2. More than half of the cases involved 3rd molars within the sinus. In 99% of cases, the sinus alveolar recess was located in the root furcation zone. The mean volume of the right sinus was 13.78±4.59 ml and that of the left sinus was 13.65±4.75 ml. Anterior sinus extensions were located in the premolar region (75%) and posterior sinus extensions were located in the tuberosity region (88 to 90%). In 3 out of 4 subjects the sinus floor had an irregular shape.

: These various insights into the relationships between the maxillary root apices and the sinus floor will be of considerable help to dental surgeons in the prevention of odontogenic maxillary sinus pathology.
Recurrent osteomyelitis in patient of osteopetrosis: A rare case report and management
Authors: Lahoti Amol Ramkishan , Shah Kanchan Milind , Landge Jayant , Ubale Nilesh , Fruitwala Asma
Published: September 2023

: Osteopetrosis is a rare heritable disease. It sometimes presents as incidental finding with no symptoms to even life threatening complications. It may present as multiple fractures, compressive neuropathies, hypocalcaemia, and life-threatening pancytopaenia.

In this article, A 15 years old female reported for evaluation and treatment of pain and pus discharge in the left side of mandible since 1 year after the extraction multiple deciduous tooth. pus discharge in the left side of mandible with draining fistula. Intraoral examination revealed exposed necrotic bone in mentioned region. 

: osteopetrosis of mandible may develop osteomyelitis. The osteomyelitis is usually due to tooth extraction or pulpal necrosis. However, its treatment is controversial.

: Treatment regimens include high-dose systemic antibiotics along with thorough debridement of necrotic bone and primary closure of soft tissues & may require Hyperbaric oxygen.
Telemedicina: uma nova forma de assistência médica ao paciente
Authors: Santos Nilton Freire , Costa Karoline Lira Dantas da
Published: September 2023

A telemedicina é uma nova forma de assistência médica ao paciente através da utilização de recursos de informática e telecomunicações, com a finalidade de promover interação entre profissionais de saúde e prestar uma assistência médica mais adequada [...].
Reações de Friedel-Crafts catalisadas por InX3
Authors: Peppe Clovis , Oliveira Carlos Alberto Fernandes de
Published: September 2023

Tri-haletos de índio são ácidos de Lewis reconhecidos e sua química de coordenação frente a ligantes de diversas categorias é bem estabelecida. De fato, desde complexos tetracoordenados a hexacoordenados todos, foram bem caracterizados e resultam de interação de 1 a 3 moléculas de um ligante (monodentado) [...].
Novas tecnologias da informação: fundamentação teórica
Authors: Sousa Beatriz Alves de
Published: September 2023

O artigo descreve, em termos gerais, as diversas tecnologias de informação que se agregam ao nosso dia a dia, definindo princípios, funções e sua aplicação nas organizações modernas [...].
Desejo e escrita: busca de libertação
Authors: Inácio Francilda Araújo , Correia Francisco José Gomes
Published: September 2023

Este texto aborda questões relativas à Literatura e à Psicanálise, de modo a evidenciar o entrelaçamento entre elas, considerando, sobretudo, ser a primeira um meio de expressão do inconsciente, uma vez sua linguagem, figurada, por excelência, é, muitas vezes, a única linguagem possível para descrever os processos psíquicos, revelando os desejos recalcados, as emoções contidas, os disfarces e as dissimulações.
ПРОБЛЕМА ЕКОЛОГІЧНОЇ ВІДПОВІДАЛЬНОСТІ НА ЗЛАМІ СТОЛІТЬ
Authors: Ченбай Наталія
Published: September 2023

Анотація. Стаття присвячена дослідженню проблеми екологічної відповідальності як однієї з форм соціальноївідповідальності, яка на початку нового тисячоліття набуває особливого значення і стає предметом всебічногодослідження науковців і філософів. Зазначено, що принцип екологічної відповідальності повинен стати центрометичних поглядів. Визначено, що вирішення проблеми ековідповідальності та розроблення принципів керування нею всучасному світі дозволить зробити значний прорив у напрямку вирішення багатьох проблем, які постали передсвітовою спільнотою наприкінці ХХ – на початку ХХІ століть.
Электромиография как способ функционального исследования в стоматологии
Authors: Криштопа С.Н., , Полещук О.Ю , Лукаш А.С. , Халилова З.С.
Published: September 2023

Электромиография (ЭМГ) используется в стоматологии для научных исследований с 1940-х годов и для клинического применения для изучения мышц челюстно-лицевой области в сочетании с физикальным осмотром, оценкой истории болезни, анализом лица и окклюзии, что имеет свои особенности
The work of student clubs of universities of the Ukrainian SSR as a means of organizing leisure during the “Khrushchev thaw”
Authors:   Donetsk National Technical University, Vlasova Natalia N.
Published: September 2023

The article deals with the leisure of students of the Ukrainian SSR in 1953–1964 on the example Kyiv State University, Kharkov State University, Odessa State University, Lviv State University and Stalin State Pedagogical Institute. Attention is paid to the cultural recreation of students,the activities ofstudentclubs in higher educational institutions andthework ofvarious amateur artcircles,which provide an opportunity for the comprehensive development of personality.
Giovanni Aguto – condottiere in the service of the Italian states
Authors:   North-Caucasus Federal University, Semikov Maksim O.
Published: September 2023

The article discussesthemilitarycareer ofthe EnglishmanGiovanni Aguto, amercenarycaptainwhoservedthe Italiancity-states of Italy and the Papal States for a long time. Based on the material of the Florentine chronicles the brothers Giovanni and Matteo Vilanni, Marchione Stefani, information reported by anonymous authors, the path from an ordinary mercenary to a famous condottiere and honorary citizen of Florence is shown. Theconclusion is made about the inconsistency of the image of Giovanni Aguto in the assessment both bycontemporaries and in the subsequent historical tradition. Giovanni Aguto combined the cruelty and greed of a mercenary captain, on the one hand, and chivalrous gestures and attitudes, on the other.
Hannah More on the significance of charity for the rich and the poor
Authors:   Saratov State University, Starokozheva Nataliya A.
Published: September 2023

The article examines one of the facets of the industrial revolution process associated with shifts in the social structure of society and changes in behavioral practices. The main attention is focused on the analysis of the views of the writer, philanthropist and teacher H. Morе. In her writings, H. More tried to contribute to strengthening social stability in society by educating “true ladies”, on the one hand, and educating obedient poor, on the other hand.
The problem of the excess of revolutionary violence in the peasant movement of 1905–1907 (based on the materials of the Saratov Province)
Authors:   Saratov State University, Varfolomeev Yuri V.
Published: September 2023

The article examines the phenomenon of revolutionary violence, cultivated and entrenched in the mass peasant consciousness at the beginning of the XX century. The author, relying on archival sources, explores the evolution and features of the excesses of revolutionary violence manifested inthe peasantmovement in 1905–1906 usingthe example ofthe Saratov province. The articleconcludesthatthesyndrome of violence in the agrarian movement has formed as an archetype of the mass revolutionizedconsciousness of the peasant masses, manifested in their illegal actions. The excess of revolutionary violence inevitably led to the marginalization of the peasantry, destroying its class values and traditions.