bluuebunny/crossref_metadata_2025 huggingface dataset:
Uniqueness of India's Northeast with respect to climate change impact: an assessment of streamflow variation in the Gomati River basin
Authors: Paul Ashesh Rudra , Maity Rajib
Published: February 2023

Impacts of climate change may vary from location to location for various reasons and may exhibit unique features in some regions. In this study, we considered India's Northeast which is geographically and hydro-meteorologically unique. The Gomati River catchment is the largest and one of the important river catchments in Tripura, a state in the northeastern region of India. Due to changes in climatic conditions over the previous few decades, the flow pattern of this catchment has changed significantly. The study examines the effect of climate change on the climatology of precipitation and streamflow using the simulation output from the Earth System Model (ESM) from the sixth phase of the Coupled Model Intercomparison Project (CMIP6) into two different conceptual hydrological models for streamflow simulation. Findings indicate that water availability is projected to be reduced in the future due to a reduction in the average streamflow volume by approximately 12–30% (varies from model to model and scenario to scenario). Moreover, the water demands for other hydrological processes, i.e., evaporation/evapotranspiration, are expected to increase due to a significant increase in temperature (∼1.4–2.1 °C). A sustainable management of water resources will benefit from the research outcomes of this study.
Interwencyjne ośrodki preadopcyjne. Znaczenie, podstawy funkcjonowania i egzemplifikacje
Authors: Krajewska Beata
Published: February 2023

Interwencyjne ośrodki preadopcyjne stały się przedmiotem eksploracji niniejszego opracowania. Celem jego jest wskazanie ich znaczenia, odniesienie się do podstaw prawnych ich organizacji oraz kompetencji, jak też egzemplifikacja istniejących placówek tego rodzaju. Interwencyjne ośrodki preadopcyjne pozostają stosunkowo mało rozpoznane w dyskursie naukowym. Artykuł ten, zgodnie z przyjętym celem, stara się wypełnić potrzebę poznania ich znaczenia i funkcjonowania, lecz także promowania, aby wiedza o tych placówkach była dostępna w społeczeństwie, aby ludzie je wspierali, powoływali do istnienia nowe instytucje, aby podmioty te mogły w jak najszerszym wymiarze otoczyć opieką dzieci z uwagi na sytuacje, w jakich się one znalazły (pozostawione bez opieki, porzucone, chore, z deficytami czy też zaburzeniami).
Bloodborne Pancreatic Amylin, a Therapeutic Target for Alzheimer's
Disease
Authors: Despa Florin
Published: February 2023

Alzheimer Disease (AD) pathology has been linked to brain accumulation of β amyloid
(Aβ) and neurofibrillary tau tangles. An intriguing question is whether targeting factors independent of
Aβ and tau pathologies could delay or even stop neurodegeneration. Amylin, a pancreatic hormone cosecreted
with insulin, is believed to play a role in the central regulation of satiation and was shown to
form pancreatic amyloid in persons with type-2 diabetes mellitus. Accumulating evidence demonstrates
that amyloid-forming amylin secreted from the pancreas synergistically aggregates with vascular
and parenchymal Aβ in the brain in both sporadic and early-onset familial AD. Pancreatic expression
of amyloid-forming human amylin in AD-model rats accelerates AD-like pathology, whereas genetically
suppressed amylin secretion protects against AD effects. Thus, current data suggest a role of
pancreatic amyloid-forming amylin in modifying AD; further research is required to test whether lowering
circulating amylin levels early during AD pathogenesis may curb cognitive decline.
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine
System from the Modern Viewpoint
Authors: Kushwah Shikha , Maurya Neha Shree , Kushwaha Sandeep , Scotti Luciana , Chawade Aakash , Mani Ashutosh
Published: February 2023

Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and
neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss,
depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology,
current drugs have failed to completely cure the disease. Natural compounds have been
investigated as an alternative therapy for their ability to treat Alzheimer's disease (AD). Traditional
herbs and formulations which are used in the Indian ayurvedic system are rich sources of antioxidant,
anti-amyloidogenic, neuroprotective, and anti-inflammatory compounds. They promote quality of life
by improving cognitive memory and rejuvenating brain functioning through neurogenesis. A rich
knowledge base of traditional herbal plants (Turmeric, Gingko, Ashwagandha, Shankhpushpi, Giloy,
Gotu kola, Garlic, Tulsi, Ginger, and Cinnamon) combined with modern science could suggest new
functional leads for Alzheimer's drug discovery. In this article Ayurveda, the ancient Indian herbal
medicine system based on multiple clinical and experimental, evidence have been reviewed for treating
AD and improving brain functioning. This article presents a modern perspective on the herbs
available in the ancient Indian medicine system as well as their possible mechanisms of action for AD
treatment. The main objective of this research is to provide a systematic review of herbal drugs that
are easily accessible and effective for the treatment of AD.
Selecting the Best Animal Model of Parkinson’s Disease for Your Research
Purpose: Insight from in vivo PET Imaging Studies
Authors: Real Caroline Cristiano , Binda Karina Henrique , Thomsen Majken Borup , Lillethorup Thea Pinholt , Brooks David James , Landau Anne Marlene
Published: February 2023

Parkinson’s disease (PD) is a debilitating neurodegenerative multisystem disorder leading
to motor and non-motor symptoms in millions of individuals. Despite intense research, there is
still no cure, and early disease biomarkers are lacking. Animal models of PD have been inspired by
basic elements of its pathogenesis, such as dopamine dysfunction, alpha-synuclein accumulation,
neuroinflammation and disruption of protein degradation, and these have been crucial for a deeper
understanding of the mechanisms of pathology, the identification of biomarkers, and evaluation of
novel therapies. Imaging biomarkers are non-invasive tools to assess disease progression and response
to therapies; their discovery and validation have been an active field of translational research.
Here, we highlight different considerations of animal models of PD that can be applied to
future research, in terms of their suitability to answer different research questions. We provide the
reader with important considerations of the best choice of model to use based on the disease features
of each model, including issues related to different species. In addition, positron emission tomography
studies conducted in PD animal models in the last 5 years are presented. With a variety
of different species, interventions and genetic information, the choice of the most appropriate model
to answer research questions can be daunting, especially since no single model recapitulates all aspects
of this complex disorder. Appropriate animal models in conjunction with in vivo molecular
imaging tools, if selected properly, can be a powerful combination for the assessment of novel therapies
and developing tools for early diagnosis.
Asenapine as a Potential Lead Inhibitor against Central Ca2+/Calmodulin-Dependent Protein Kinase II: Investigation by Docking Simulation and Experimental Validation
Authors: Daoud Safa , Abutayeh Reem , Alabed Shada J. , Taha Mutasem O.
Published: February 2023

Aim:

The aim of this potential repurposing study is to investigate the potential inhibitory activity of asenapine against central nervous system CaMKII isozymes using docking experiments and enzymatic assay.

Background:

The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional protein kinase ubiquitously expressed throughout the brain. Emerging biological data have indicated that inhibiting central nervous system CaMKII isoforms, namely, CaMKIIα and CaMKIIβ, may be a promising therapeutic strategy for the potential treatment of many neurological diseases including schizophrenia, depression, epilepsy, and learning deficit.

Objective:

1- Study the possible attractive interactions of asenapine within the binding sites of the central CaMKII isozymes. 2- Evaluate the inhibitory activities of asenapine against central CaMKII isozymes.

Methods:

Docking experiments of asenapine and other known CaMKII inhibitors were performed. Docking settings were validated using ROC analysis. After that, the inhibitory activities of asenapine against central CaMKII alpha and beta were evaluated by enzymatic assay.

Result:

Docking and scoring experiments of asenapine showed several binding interactions anchoring asenapine within CaMKIIα and CaMKIIβ catalytic sites while enzymatic assay results revealed that asenapine can inhibit CaMKIIα and CaMKIIβ in the micromolar range.

Conclusion:

Our study provides evidence that asenapine can serve as a promising lead for the development of new CaMKIIα and CaMKIIβ inhibitors. Moreover, this study reinforces how the investment in drug repurposing could boost the drug discovery process.
Multi-Class Classification of Gastrointestinal Diseases using Deep Learning Techniques
Authors: Mary X.Anitha , Raj A. Peniel Winifred , Evangeline C. Suganthi , Neebha T. Mary , Kumaravelu Vinoth Babu , Manimegalai P.
Published: February 2023

Objective:

Currently, gastrointestinal problems claim the lives of about two million individuals every year throughout the world. Video endoscopy is one of the most important tools for detecting gastrointestinal diseases (GD). However, it has the disadvantage of producing a huge quantity of images that should be analysed by medical professionals, which demands more time. This makes manual diagnosis challenging, encouraging research into computer-assisted methods for accurately identifying all of the produced images in a short amount of time. The goal of this research is to develop anArtificial intelligence technique to classify the different diseases in gastrointenstine.

Materials and Methods:

In developing a framework for classifying gastrointestinal diseases, the proposed methodology is unique. VGG-19 and ResNet-50, two deep learning networks, were used to evaluate their ability to recognise a dataset of lower GD. To validate the proposed models, a Kvasir dataset of 3500 images was employed, comprising 500 images from each of the seven classes.

Results:

ResNet-50 had the greatest validation accuracy of 96.81%, recall of 95.28%, precision of 95%, and 94.85% of F1 score, whereas VGG-19 had the highest validation accuracy of 94.21%, recall of 94%, precision of 94.28%, and 94% of F1 score.

Conclusions:

The Convolutional neural network (CNN) was used to extract shape, colour, and texture features. Softmax assists in the classification of seven types of GD by passing these features into fully connected layers. Two models performed equally well and yielded promising results.
Pendidikan karakter jujur melalui metode bercerita di sekolah dasar di Yogyakarta
Authors: Nurbaya St. , Rukiyati Rukiyati , Sutrisnowati Sri Agustin
Published: February 2023

Pendidikan karakter jujur terintegrasi ke dalam tema-tema pelajaran dengan  metode bercerita  penting dilakukan sebagai upaya mendidik siswa agar menjadi orang yang jujur. Penelitian ini bertujuan untuk mendeskripsikan praktik pendidikan karakter jujur melalui metode bercerita bagi siswa kelas 4 pada tujuh sekolah dasar di Yogyakarta. Buku panduan untuk guru dan buku cerita telah dikembangkan pada penelitian sebelumnya dan telah dinyatakan valid serta  layak digunakan, menurut para ahli maupun guru.Metode penelitian ini adalah deskriptif kualitatif dengan menggunakan model interaktif dari Miles, Huberman dan Saldana (2014).Teknik  pengumpulan data yang digunakan adalah observasi, dan diskusi grup terfokus, didukung dengan penggunaan skala Likert untuk mengukur sikap siswa terhadap kejujuran. Teknik analisis data dilakukan secara interaktif meliputi kondensasi data, penyajian data dan penarikan kesimpulan. Keabsahan data dilakukan dengan triangulasi sumber dan teknik. Hasil penelitian menyimpulkan praktik pendidikan karakter jujur melalui metode bercerita untuk siswa kelas IV sekolah dasar telah berhasil dilaksanakan dengan baik. Guru telah dapat melaksanakan pembelajaran sesuai buku panduan dan siswa telah memahami arti penting kejujuran dalam berbicara dan bertindak. Siswa menyatakan sikap setuju terhadap pernyataan dan tindakan yang jujur. Oleh karena itu, pendidikan karakter jujur melalui metode bercerita dapat digunakan secara luas sebagai upaya menanamkan nilai kejujuran dalam diri siswa sekolah dasar.  Kata kunci:  nilai, karakter, jujur, dan metode bercerita
Reactivity of stress-implementing system under conditions of light regime change in experiment
Authors: Zlobina O. W.  , Pakhomy S. S.  , Bugaeva I. O.  , Ivanov A. N.  , Moskvina A. O.  , Kostromina E. M.
Published: February 2023

Influence of light exposure duration (model 18:6) on hormonal indices of stress-implementing system in laboratory animals blood is studied. Activity of stress systems central link was evaluated based on data on concentration of adrenocorticotrophic hormone, melatonin and β-endorphin in blood serum, observed during enzyme immunoassay. Reaction of peripheric link of the stress-implementing system was evaluated in blood smears based on results of qualitative count of catecholamine granules in erythrocytes. It was established, that variations of hormonal indices of the stress systems for laboratory animals depend on trigger factor activity periods. With increase of the experiment duration to 21-st days the most pronounced reduction of melatonin, β-endorphin and increase of adrenocorticotrophic hormone concentration, as well as sharp increase of catecholamines level are observed in the blood serum. These hormonal changes develop as a result of failure of compensation mechanisms of the stress-implementing systems in connection with melatonin rhythms disturbance, that indicates the gradual development of the general adaptation syndrome. Keywords: endocrine profile, stress-implementing system, general adaptation syndrome, biorhythms, light desynchronosis.
Noise influence on characteristics of current, flowing through semiconductor superlattice, in high frequency oscillation mode
Authors: Selskii A. O.  , Moskalenko O. I.  , Koronovskii A. A.
Published: February 2023

Noise influence on characteristics of current, flowing through semiconductor superlattice of nanodevice with prospects of using in terahertz spectroscopy, is examined. It is demonstrated, that the limit voltage, at which the current oscillations start, slightly depends on noise intensity. Oscillation amplitude increases at some noise intensity values for case without magnetic field and in the presence of a tilted magnetic field. At the same time with increase of noise intensity at developed oscillations the basic frequency decreases, while higher harmonics amplitudes can significantly decrease. Keywords: semiconductor superlattices, microwave devices, high frequency spectroscopy, added noise, spectral analysis.
Extremely short pulses in anisotropic optical media with carbon nanotubes taking into account multiphoton absorption
Authors: Konobeeva N.N.  , Belibikhin S.V.  , Belonenko M.B.
Published: February 2023

In this paper, we study the influence of multiphoton absorption on the propagation of electromagnetic waves in a nonlinear optical anisotropic medium with carbon nanotubes. The effective equation for the vector potential of the electromagnetic field of the pulse is obtained, taking into account the second component of the polarization of the field, as well as two- and three-photon absorption processes. The dependence of the components of the pulse field on the parameters of the problem is revealed. Keywords: optical anisotropy, extremely short pulse, multiphoton absorption.
Emission spectra of liquid-jet targets of hexane C-=SUB=-6-=/SUB=-H-=SUB=-14-=/SUB=-, dichloromethane CH-=SUB=-2-=/SUB=-Cl-=SUB=-2-=/SUB=-, methylene bromide CH-=SUB=-3-=/SUB=-Br in the range 4-20 nm under pulsed laser excitation
Authors: Guseva V. E.  , Nechay A. N.  , Perekalov A. A.  , Salashchenko N. N.  , Chkhalo N. I.
Published: February 2023

The article discusses the results of studying the emission spectra of liquid hexane C6H14, dichloromethane CH2Cl2, methylene bromide CH3Br upon excitation by pulsed laser radiation. We used a Nd : YAG,laser, λ=1064 nm, tau=5.2 ns, Epulse=0.8 J. The spectral range of 4-20 nm was studied. We used injector with a hole 225 μm ?m in diameter, operating in a pulsed mode to form a liquid-droplet jet. The emission spectra of these liquid-jet targets were obtained. The obtained spectra were decoded, and the ions emitting in this spectral range were determined Keywords: extreme ultraviolet radiation, emission spectra, laser spark, x-ray spectrometer-monochromator, liquid jets.
Investigation of the optical properties of a BiFeO-=SUB=-3-=/SUB=-/SrTiO-=SUB=-3-=/SUB=- heterostructure grown on an Al-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-(0001) substrate by RF cathode sputtering
Authors: Kara-Murza S. V.  , Zhidel K. M.  , Korchikova N. V.  , Silcheva A. G.  , Tekhtelev Yu. V.  , Chizhov R. G.  , Pavlenko A. V.
Published: February 2023

The phase composition, structure, and optical properties of the BiFeO3/SrTiO3/Al2O3 (c-cut) heterostructure have been studied using XRD analysis, spectrophotometry, and multi-angle ellipsometry. BFO/STO/Al2O3 heterostructures have been obtained by high-frequency cathode sputtering in an oxygen atmosphere using the intermittent deposition technology. It was found that the BiFeO3 and SrTiO3 layers grew with an orientation in the direction of the [111] crystallographic axis parallel to the normal to the Al2O3 substrate. It has been shown that the damaged layer on the surface of the heterostructure does not exceed 2-3 nm, and no signs of the presence of boundary layers at the Al2O3-SrTiO3 and SrTiO3-BiFeO3 interfaces have been identified. The dispersion dependences of the refractive indices of BFO and STO layers are calculated. The reasons for the revealed regularities are discussed. Keywords: thin films, multiferroic, optical properties, ellipsometry, bismuth ferrite.
Моделирование оптических неоднородностей в Cr-=SUP=-2+-=/SUP=-:CdSe-лазерах с подвижными активными элементами
Authors: Волков М.В. , Гарюткин В.А. , Захаров Н.Г. , Мищенко Г.М. , Рябов В.О. , Стариков Ф.А.
Published: February 2023

The work is devoted to modeling the heating of moving active elements from CdSe and
estimates emerging optical inhomogeneities. Active elements in the form of a parallelepiped are
considered, which rotated in a circle perpendicular to the generation axis. As a result of
calculations, it was found that the temperature distribution in the active element that occurs
during the operation of the laser can be represented as the sum of two components. The first
component is formed due to the balance between heat emission in the active element due to
pumping and heat removal from it, which leads to the appearance of an aberration, which is the
sum of "tilt" and "defocusing". The second component is formed directly during the passage of
the pump spot through the active element, is determined only by the heat release density and is
not related to the cooling method of the active element. It leads to the appearance of "Gaussian"
aberration, the amplitude of this aberration is directly proportional to the power of heat emission
and inversely proportional to the frequency of rotation of the active element.
Принцип организации канала подводной радиосвязи с использованием шаровых антенн
Authors: Томилин А.К.
Published: February 2023

The principle of operation of spherical antennas, which were used in experiments on the transmission of a short-wave radio signal in the marine environment, is theoretically described. A solution of a spherically symmetric electrodynamic problem based on the experimentally found potential component of the magnetic field is proposed. The characteristics of a potential wave process in an electrically conductive medium are determined. The law of transformation of an electromagnetic wave at the "conductor-dielectric" interface has been established.
Аналитические возможности термодесорбционного спектрометра с поверхностно-ионизационным детектированием молекул органических веществ в воздухе
Authors: Раджабов А.Ш. , Хасанов У. , Исхакова С.С. , Ахмедов Ш.М. , Кахраманова Г.П. , Ахунов Ш.Дж. , Усманов Д.Т.
Published: February 2023

Abstract
This paper presents the results of research on the development of a mathematical model of thermal desorption spectrometry with a surface ionization method for detecting molecules of organic substances, as well as an analysis of the capabilities of a thermal desorption spectrometer operating on the basis of this method. The mathematical model of the method was developed on the basis of the regularities of thermal desorption spectrometry, as well as the regularities of surface ionization of molecules of organic substances under non-stationary conditions. The spectrometer consists of a surface ionization detector and an evaporator of substances heated in a thermally programmed mode. The adjustment and selection of the operating mode of the spectrometer were carried out on the basis of the mathematical model of the method. The analytical capabilities of the spectrometer were studied by comparing the thermodesorption spectra of a mixture of chromatographically pure cannabinoids and an extract of the biological fluids of a marijuana user (blood, urine), as well as the spectra of chromatographically pure morphine and urine extracts of a heroin user. The results of the analysis showed the perspectives of the proposed method and instrument for the detection and analysis of drugs and psychotropic drugs in extracts of biomaterials of consumers of these substances without chromatographic separation.
Autistic Traits Correlate with Chronic Musculoskeletal Pain: A Self-Selected Population Based Survey
Authors: Ryan Laura , BEER HARRIET , Thomson Ella , Philcox Edward , Kelly Clive
Published: February 2023

Chronic musculoskeletal pain is an increasingly frequent feature in young people. Many exhibit a range of additional physical and psychological features and fulfil criteria for fibromyalgia. Hypermobility, irritable bowel syndrome and migraine are frequent comorbid conditions. These are all in part mediated by dysfunction of the autonomic nervous system and commonly include fatigue, poor sleep and brain fog. Anxiety, social withdrawal and a range of autistic traits are frequently described by those with chronic musculoskeletal pain, and autistic people are over-represented among patients attending pain clinics. This study was designed to explore the correlation between the degree of pain and autistic traits described within a self-selected community-based population. The study used a nonexperimental, correlational design with data collected from a volunteer sample of 448 adults (aged 18-60) who completed online self-report questionnaires assessing each of autistic traits (RAADS-R score), fibromyalgia symptoms (ACR criteria) and hypermobility (Beighton’s test). Correlation analysis and linear regressions were used to test the relationships between each disorder. Data was analysed using parametric and non-parametric techniques to assess prevalence, strength and significance of relationships, causes of variance within populations and mediations. Our self-selected community population had a mean age of 24 years and was 77% female. The prevalence of significant autistic traits, fibromyalgia and hypermobility were all much greater than expected at 63.4%, 40.6% and 43.7% respectively. Those identifying as non-binary or trans had the highest rates. Fibromyalgia was significantly associated with autistic traits, with dysautonomia a stronger predictor than chronic pain. Regression analyses revealed hypermobility partially mediated the relationship between autistic traits and fibromyalgia. This is the first community study to provide evidence for a direct association between fibromyalgia and autistic traits. Although self-selected, the findings in our predominantly young female population confirm that these conditions are common and that those with autistic traits are at significantly increased risk of developing fibromyalgia, especially if they are hypermobile.
Projections of Lung Cancer Incidence by 2035 in 40 Countries Worldwide: Population-Based Study
Authors: Luo Ganfeng , Zhang Yanting , Etxeberria Jaione , Arnold Melina , Cai Xiuyu , Hao Yuantao , Zou Huachun
Published: February 2023

Background

The global burden of lung cancer (LC) is increasing. Quantitative projections of the future LC burden in different world regions could help optimize the allocation of resources and provide a benchmark for evaluating LC prevention and control interventions.

Objective

We aimed to predict the future incidence of LC in 40 countries by 2035, with an emphasis on country- and sex-specific disparities.

Methods

Data on LC incidence from 1978 to 2012 were extracted from 126 cancer registries of 40 countries in Cancer Incidence in Five Continents Volumes V-XI and used for the projection. Age-standardized incidence rates (ASRs) per 100,000 person-years and the number of incident cases were predicted through 2035, using the NORDPRED age-period-cohort model.

Results

Global ASRs of the 40 studied countries were predicted to decrease by 23% (8.2/35.8) among males, from 35.8 per 100,000 person-years in 2010 to 27.6 in 2035, and increase by 2% (0.3/16.8) among females, from 16.8 in 2010 to 17.1 in 2035. The ASRs of LC among females are projected to continue increasing dramatically in most countries by 2035, with peaks after the 2020s in most European, Eastern Asian, and Oceanian countries, whereas the ASRs among males will continue to decline in almost all countries. The ASRs among females are predicted to almost reach those among males in Ireland, Norway, the United Kingdom, the Netherlands, Canada, the United States, and New Zealand in 2025 and in Slovenia in 2035 and even surpass those among males in Denmark in 2020 and in Brazil and Colombia in 2025. In 2035, the highest ASRs are projected to occur among males in Belarus (49.3) and among females in Denmark (36.8). The number of new cases in 40 countries is predicted to increase by 65.32% (858,000/1,314,000), from 1.31 million in 2010 to 2.17 million in 2035. China will have the largest number of new cases.

Conclusions

LC incidence is expected to continue to increase through 2035 in most countries, making LC a major public health challenge worldwide. The ongoing transition in the epidemiology of LC highlights the need for resource redistribution and improved LC control measures to reduce future LC burden worldwide.
La democracia erosionada Przeworski, Adam (2022), Las crisis de la democracia. ¿Adónde pueden llevarnos el desgaste institucional y la polarización?, Buenos Aires, Siglo XXI Editores
Authors: Fernández Vega José
Published: February 2023

No disponible
Las políticas de Donald Trump en las relaciones comerciales y en la migración: su desafío para México en la compleja interdependencia histórica con los Estados Unidos
Authors: Zamitiz Gamboa Héctor
Published: February 2023

El artículo analiza un complejo periodo histórico del México contemporáneo, en el que se vio afectada la relación binacional con Estados Unidos, ocasionada por un cambio de enfoque en las políticas de ese país, a raíz de las estrategias discursivas y acciones de gobierno (órdenes ejecutivas) del presidente Donald Trump, en el sector automotriz, en la política migratoria, en la seguridad (con la construcción de un muro fronterizo) y en la renegociación del tlcan. Desde su campaña como candidato del Partido Republicano tomó a México como objetivo para ejemplificar su diagnóstico de una “incompatibilidad de proyectos”, a partir de que determinados países se aprovechaban de las ventajas que les deparaba su relación comercial –a través del tlcan– y por el número de migrantes existentes en Estados Unidos
Typology of Tourism Village Settlement in Indonesia
Authors: Salouw Elvis , Widodo Dwi Pramono Retno
Published: February 2023

As a fast-growing industry sector, tourism has become an essential economic basis for villages. Law No 6 of 2014 has broadened the opportunity for villages to develop. A tourism village is considered one of the community empowerment options that can improve the economy and the village's development. Moreover, with all their uniqueness, tourism villages are also regarded as capable of eliminating urbanization's negative impact. Of 83.820 villages in Indonesia, 2% of them are tourism villages. This study took a sample of 55 tourism villages selected by the purposive sampling method and then described the sample based on five typologies, namely the settlement configuration, the classification of the village, the accessibility, the tourist attraction, and the category of the tourism village. The data used in the study were collected from various sources, specifically, those taken from official documents, credible websites, and previous studies to describe the typology owned by villages to become fast-growing tourism villages. The results show that, generally, tourist villages in Indonesia are dominated by rural tourism villages; however, urban tourism villages have a faster development. This study also points out the determining aspect of tourist village development.
An update on recent developments and highlights in food allergy
Authors: Locke Arielle , Hung Lisa , Upton Julia , O'Mahony Liam , Hoang Jennifer , Eiwegger Thomas
Published: February 2023

While both the incidence and general awareness of food allergies is
increasing, the variety and clinical availability of therapeutics remain
limited. Therefore, investigations into the potential factors
contributing to the development of food allergy and the mechanisms of
natural tolerance or induced desensitization are required. In addition,
a detailed understanding of the pathophysiology of food allergies is
needed to generate compelling, enduring, and safe treatment options. New
findings regarding the contribution of barrier function, the effect of
emollient interventions, mechanisms of allergen recognition, and the
contributions of specific immune cell subsets through rodent models and
human clinical studies provide novel insights. With the first approved
treatment for peanut allergy, the clinical management of food allergy is
evolving towards less intensive, alternative approaches involving fixed
doses, lower maintenance dose targets, co-administration of biologicals,
adjuvants, and tolerance-inducing formulations. The ultimate goal is to
improve immunotherapy and develop precision-based medicine via risk
phenotyping allowing optimal treatment for each food-allergic patient.
Strawberry gingivitis: an isolated manifestation of Wegener's granulomatosis?
Authors: Lourenço SV , Nico MM.
Published: February 2023

This article does not have an abstract.
Students’ Perception Toward the Efl Lecturer’s Code-Switching in PGSD’S English Classroom
Authors: Fatsah Hasanuddin , Purnama Indah
Published: February 2023

Primary school is the foundation of formal schooling which can affect the aftermath. This study analyses the perception of Primary school teacher education or PGSD student toward the code-switching made by EFL lecturers in English classrooms and the benefits for them in learning English. This study using a mixed-method, the eligible participant received questionnaire and semi-structured interview protocols were carried out in the Indonesian language. The data from the questionnaire was analyzed by Likert scale and the semi-structured interview was analyzed by thematic analysis. The findings showed that first, students have a positive perception toward the code-switching done by the lecturer in English classroom; second, benefits that the students get from code-switching in English classroom are increase the level of English vocabulary capacity mastery, help in understanding lessons, learn the English language better, help understanding course assignments, improves English speaking skill, improves English listening skill. As the conclusion, the code-switching used for teaching English in the classroom had given great impact on PGSD students which is most of the students showed a positive perception toward the used of Code-switching.
Model Pembelajaran Sains Teknologi Masyarakat (STM) DAN Penilaian Autentik terhadap Hasil Belajar Siswa
Authors: Jayadiningrat Made Gautama , Widiana I Wayan , Tria Ariani Nyoman Wiraadi , Widiani Ni Komang
Published: February 2023

Prestasi sains siswa Indonesia berada di bawah rata-rata internasional. Hal ini akibat dari pembelajaran masih berpusat pada guru dan kurangnya aktivitas fisik siswa. Maka perlu diadakan pembaharuan untuk mendukung pembelajaran yang bersifat kontekstual. Sains Teknologi Masyarakat (STM) merupakan suatu model pembelajaran yang dapat dijadikan alternatif dalam pengelolaan kelas dalam pembelajaran. Penelitian ini bertujuan untuk menganalisis pengaruh model pembelajaran Sains Teknologi Masyarakat (STM) dan asesmen autentik terhadap hasil belajar siswa. Jenis penelitian ini adalah penelitian semu (quasi experiment) dengan rancangan the posttest only control group design. Populasi dan sampel dalam penelitian ini semua kelas V SD sebanyak 81 siswa.  Data hasil belajar dikumpulkan dengan tes objektif. Analisis data yang digunakan dalam penelitian ini adalah uji ANAVA dua jalur dan dilanjutkan dengan Uji-t. Berdasarkan hasil penelitian dan pembahasan menunjukkan bahwa bahwa model pembelajaran STM dan asesmen autentik mempunyai pengaruh positif yang signifikan terhadap hasil belajar IPA. Model pembelajaran STM yang dientegrasikan dengan asesmen proyek memberikan hasil yang paling baik. Kombinasi ini sangat cocok diaplikasikan untuk mata pelajaran IPA di sekolah dasar karena model tersebut mengakomodasi karakteristik pendidikan IPA. Model pembelajaran STM dapat mengeksplorasi rasa ingin tahu siswa terhadap isu-isu sains dan teknologi melalui tahap penggalian isu-isu sains dan teknologi. Sedangkan asesmen proyek membuat anak bisa mengasimilasi dan mengakomodasi rangsangan dari lingkungannya, berinteraksi dengan objek, mengamati, meneliti, dan berpikir sehingga meningkatkan kemampuan kognitif nya.
Cohesión social y satisfacción con la colonia: estudio en comunidades urbanas de ingreso medio-bajo
Authors: Ibarra Salazar Jorge , Salazar Cantú José de Jesús , Navarro Aguirre Rafael
Published: February 2023

En este artículo se analiza la relación entre la cohesión social y la satisfacción con la colonia, un indicador del bienestar de los residentes. Usando datos de una encuesta aplicada a habitantes de dos colonias en Monterrey, Nuevo León, calculamos un índice de cohesión social considerando una serie de atributos del medio ambiente social (confianza vecinal, participación vecinal, comportamiento participativo e identidad vecinal) para relacionarlo con el grado de satisfacción con su colonia. Estimamos diferentes especificaciones por probit y probit ordenado. Encontramos evidencia de que la cohesión social tiene una relación positiva y estadísticamente significativa con el grado de satisfacción con la colonia. Este resultado contribuye no sólo a la literatura relacionada, sino a validar los programas sociales y la política pública cuyo objetivo es aumentar el bienestar de los ciudadanos a través de acciones encaminadas a mejorar la cohesión social.
Un vuelo sin destino: el Nuevo Aeropuerto Internacional de la Ciudad de México
Authors: Soto Coloballes Natalia Verónica
Published: February 2023

El presente texto describe las diversas acciones y proyectos para construir una terminal aeroportuaria en la Zona Federal del Lago de Texcoco a lo largo de más de veinte años. Se trata de un panorama general que permite dilucidar dos posturas al respecto: la de aquellos convencidos de su edificación y la de los opositores a este megaproyecto. Esto con el fin de observar la relevancia y el cambio de la noción misma de suelo, dada su transformación y carencia, lo que está conectado también con la valoración de los recursos naturales.
Patrones de viajes por motivo de trabajo, escuela y compras en la Zona Metropolitana de Querétaro
Authors: Obregón-Biosca Saúl Antonio
Published: February 2023

Las zonas metropolitanas concentran población y atraen actividades económicas, induciendo la necesidad de realizar viajes dentro de su territorio. Por ello, la presente investigación analiza las características y distribución espacial de los viajes por motivos tanto obligados como opcionales en los principales medios de transporte, y se emplea la encuesta Origen Destino para analizar el modelo clásico de la movilidad. Los resultados muestran que el autobús es el principal medio para realizar desplazamientos por motivo educativos, mientras el automóvil es mayormente utilizado con proósitos de compras y de trabajo, además que la centralidad de la residencia se relaciona directamente con la del empleo.
Heterogeneidad estructural en la ciudad latinoamericana. Más allá de los dualismos
Authors: Schteingart Garfunkel Martha
Published: February 2023

Es una obra útil e importante para los investigadores de las ciencias sociales que se interesan por la cuestión urbana en América Latina y particularmente en cómo interpretarla a partir de una nueva visión de la teoría marxista, pudiendo también alcanzar a los estudiosos de esa teoría interesados en conocer nuevos planteos sobre la “heterogeneidad estructural” en las sociedades o ciudades latinoamericanas, como indica el título de la obra. En el libro el autor busca revisar de manera crítica los planteamientos positivistas elaborados alrededor de la oposición formalidad-informalidad y sus consecuencias políticas; asimismo, procura contribuir al desarrollo de la reflexión sobre esos temas desde la tradición marxista.
Interpretação socioespacial em comunidades tradicionais na Amazôniapela teoria de Christpher Alexander
Authors: Nascimento Izabel Cristina Melo de Oliveira , Perdigão Ana Klaudia de Almeida Viana
Published: February 2023

As comunidades tradicionais da Amazônia, em seu cotidiano, realizam práticas espaciais que reproduzem seus aspectos culturais, sociais e ancestrais. Portanto, essas comunidades são analisadas, aqui, a fim de evidenciar seu modo peculiar de morar no que diz respeito ao espaço habitado socialmente construído. Uma interpretação socioespacial foi realizada no Furo do Nazário, Pará, Brasil, e na Ilha de Sababa, Maranhão, Brasil, utilizando-se as Propriedades Fundamentais e Linguagem de Padrões, de Christopher Alexander, como base teórica e instrumental de análise, com destaque para os aspectos de conexão e de contraste. Identificou-se, assim, que a relação entre o espaço edificado e o seu uso é particular e representativo de cada agrupamento. Contudo, alguns elementos evidenciam a existência de semelhanças coerentes, o que possibilita a caracterização da moradia tradicional na Amazônia. O ambiente habitado é a expressão da necessidade espacial de seus usuários, e se edifica na prática do conhecimento herdado e no cotidiano relacionado ao seu território.
Diagnostyka i leczenie ostrego zespołu przedsionkowego – opis przypadku
Authors: Józefowicz-Korczyńska Magdalena
Published: February 2023

W pracy opisano przypadek leczenia pacjenta z pierwszym epizodem nagłych, układowych zawrotów głowy. Ze względu na czynną chorobę wrzodową niemożliwe było zastosowanie farmakoterapii betahistyny.
Holistyczne podejście do leczenia metotreksatem w reumatologii i dermatologii
Authors: Kwiatkowska Brygida
Published: February 2023

Metotreksat w formie doustnej lub podskórnej jest zarejestrowany m.in. w leczeniu reumatoidalnego zapalenia stawów, łuszczycy i łuszczycowego zapalenia stawów. Wybór formy powinien opierać się na analizie potrzeb i stanu danego pacjenta oraz właściwości farmakologicznych danej formy. W pracy przedstawiono różnice między formą doustną a formą podskórną metotreksatu.
Zawroty głowy u seniorów – opis przypadku
Authors: Onopiuk Paweł , Pionka Mateusz
Published: February 2023

Zawroty głowy u osób starszych są znacznie poważniejszym problemem niż w innych grupach wiekowych ze względu na zwiększone ryzyko upadków i wtórnych złamań. Ze względu na to, że zaburzenia te mają szeroką etiologię: od uszkodzenia układu przedsionkowego, poprzez zaburzenia sercowo-naczyniowe, metaboliczne, intoksykacje, uszkodzenie zarówno obwodowego, jak i ośrodkowego układu nerwowego, aż po dolegliwości psychogenne, w leczeniu osób starszych konieczne jest zidentyfikowanie pacjentów z poważnymi schorzeniami, wymagających pilnej diagnostyki i leczenia w warunkach szpitalnych. W pracy przedstawiono model diagnostyki i leczenia pacjenta z łagodnymi położeniowymi zawrotami głowy.
Wczesna diagnostyka bólu pleców. Co zrobić, żeby nie przeoczyć ZZSK?
Authors: Rupiński Robert
Published: February 2023

Przewlekły ból pleców, szczególnie okolicy lędźwiowo-krzyżowej, stanowi jedną z najczęstszych przyczyn konsultacji lekarskich. Odpowiadają za niego zwykle zmiany zwyrodnieniowo-przeciążeniowe kręgosłupa (niespecyficzne bóle pleców). Wśród innych, rzadszych przyczyn bólów pleców należy wymienić zapalne choroby kręgosłupa i stawów krzyżowo-biodrowych, czyli tzw. spondyloartropatie (SpA), w tym przede wszystkim zesztywniające zapalenie stawów kręgosłupa (ZZSK). Wczesne rozpoznanie ZZSK (SpA) ma podstawowe znaczenie dla zahamowania postępu choroby, poprawy jakości życia oraz rokowania. Niesteroidowe leki przeciwzapalne (NLPZ) odgrywają podstawową rolę w farmakoterapii zarówno niespecyficznego bólu pleców, jak i ZZSK.
Study on the post-embryonic development of Striatoppia milii Sanyal and Basu, 2014 (Acari: Oribatida: Oppiidae) on the microfungus Trichoderma harzianum
Authors: Karimbakkandi Praveena , Thalakkattil Raghavan Sobha
Published: February 2023

The present work is a study on the post-embryonic development of the oribatid mite Striatoppia milii from the family Oppidae. Striatoppia milii specimens were reared under laboratory conditions at a relative humidity of 80±2% and temperature of 27±2 °C. During the study time, both adult and immature forms of S. milii fed on the microfungus Trichoderma harzianum. The total developmental duration of the life stages of S. milii from egg to adult was 21.4±1.5 days with five active instars: larva, protonymph, deutonymph, tritonymph and adult. Given their nutritional preferences and short development cycle, they might be used in agriculture by improving the process of biodegradation.
A literature review on current practices, knowledge, and viewpoints on pentobarbital euthanasia performed by veterinarians and animal remains disposal in the United States
Authors: Kollias Nathaniel S. , Hess Warren J. , Johnson Cia L. , Murphy Mike , Golab Gail
Published: February 2023

Sodium pentobarbital and pentobarbital combination products are commonly used by veterinarians throughout the US for euthanasia of their animal patients. The AVMA Guidelines for the Euthanasia of Animals: 2020 Edition lists barbiturate acid derivatives (pentobarbital) and pentobarbital combination products as an acceptable method of euthanasia for all species when circumstances permit their use. When using pentobarbital products, a veterinarian must consider appropriate handling and disposal of animal remains to avoid the potential for environmental contamination, relay toxicosis in wildlife or domestic animals, and contamination of the animal food supply. Failure to appropriately consider these facets of pentobarbital euthanasia can result in legal and ethical consequences. Despite these concerns, to the authors’ knowledge no comprehensive literature review has been published concerning pentobarbital euthanasia or handling and disposal of animal remains following pentobarbital euthanasia. The literature review that follows aims to give a descriptive narrative of the most recent information available on the knowledge, use, challenges, and issues surrounding pentobarbital euthanasia and disposal of animal remains within the US.
Forecasting the Number of Road Accidents in Poland Depending on the Day of the Week using Neural Networks
Authors: Gorzelanczyk Piotr , Tylicki Henryk
Published: February 2023

The number of road accidents in the world is decreasing year by year. This number has been affected by the pandemic in recent years but is still very high. Therefore, it is necessary to take all possible measures and steps to reduce this number. The objective of the article is to forecast the number of road accidents in Poland depending on the day of the week. For this purpose, the annual data on the number of road accidents in Poland broken down by days of the week were analyzed, and a forecast for the years 2022-2040 was prepared on the basis of the police statistics. The forecast was made using selected models of neural networks. The research results show that a decrease in in the number of road accidents can be expected. However, the obtained results could be affected by the selected number of random samples (training, testing and validation).
Keragaman dan Korelasi Dimensi Panjang Bagian Kaki Depan dan Belakang Tubuh Induk Sapi Bali di Pusat Pembibitan Sapi Bali Unggul Gerokgak, Buleleng, Bali
Authors: Adinda Adinda , Suatha I Ketut , Susari Ni Nyoman Werdi
Published: February 2023

Penelitian ini dilakukan pada 25 ekor sapi yang ada di Pusat Pembibitan Sapi Bali Unggul di Gerokgak, kabupaten Buleleng. Pengambilan data dilakukan dengan metode purposive sampling dan kemudian diolah menggunakan SPSS IBM 26 dengan analisis deskriptif dan biplot, kemudian disajikan dalam bentuk tabel dan grafik biplot. Hasil yang diperoleh menunjukkan  bahwa koefisien keragaman yang paling beragam adalah panjang kaki depan bagian  atas sebesar 22,8369%, kemudian disusul oleh panjang kaki  belakang bagian  atas sebesar 19,3704%, panjang kaki belakang bagian tengah sebesar 17,1938%, panjang kaki depan bagian bawah memperoleh nilai sebesar 14,3102%, panjang kaki  depan bagian tengah sebesar 12,0132% dan yang paling seragam adalah panjang kaki belakang bagian bawah sebesar 10,6815%. Panjang kaki belakang bagian bawah berkorelasi positif dengan panjang kaki depan bagian bawah,  panjang kaki belakang bagian tengah berkorelasi positif dengan panjang kaki depan bagian tengah, demikian juga panjang kaki belakang bagian atas berkorelasi positif dengan panjang kaki depan bagian tatas,  tetapi panjang kaki depan bagian tengah berkorelasi negatif dengan anjang kaki belakang bagian atas dan antara panjang kaki depan bagian tengah  dan panjang kaki belakang bagian atas tidak berkorelasi dengan panjang kaki depan bagian atas. Untuk mendapat induk sapi bali yang seragam perlu melakukan seleksi terhadap panjang kaki depan bagian atas.
Deteksi Antibodi Maternal Newcastle Disease pada Broiler
Authors: Permana Ida Bagus Ketut Indra , Suardana Ida Bagus Kade , Nindhia Tjokorda Sari
Published: February 2023

Seringkali titer antibodi yang dihasilkan pascavaksinasi tidak seperti yang diharapkan, salah satu faktor penyebabnya adalah antibodi maternal. Antibodi maternal yang diperoleh secara pasif dapat menghambat pembentukan imunoglobulin, sehingga antigen vaksin akan ternetralisir. Penelitian ini bertujuan untuk untuk mendeteksi antibodi maternal Newcastle Disease pada broiler yang berguna untuk menentukan umur ayam yang paling tepat untuk divaksinasi. Penelitian ini menggunakan 10 ekor broiler belum divaksinasi yang dibagi ke dalam 3 taraf waktu pengambilan darah yaitu pada umur 7, 14, dan 21 hari melalui vena brachialis. Jumlah serum darah yang diambil dari masing-masing umur adalah 10 sampel. Serum yang diperoleh kemudian diuji secara serologis melalui uji haemaglutination (HA) dan haemaglutination inhibition (HI) untuk mendapatkan titer antibodi. Data yang diperoleh dianalisis secara deskriptif serta dilanjutkan analisis regresi menggunakan program SPSS. Hasil penelitian menunjukkan terjadi penurunan titer antibodi maternal Newcastle Disease pada broiler umur 7 hari dengan titer 6,1 HI log 2, menjadi 2,8 HI log 2 pada umur 14 hari, dan 1,8 HI log 2 pada umur 21 hari. Program vaksinasi Newcastle Disease paling tepat dilakukan pada saat broiler berumur 10 hari karena titer antibodi maternal sudah berada pada ambang batas positif yaitu 4 HI log 2.