bluuebunny/crossref_metadata_2025 huggingface dataset:
Toll-like receptor 3: a double-edged sword
Authors: Hsieh Marvin L , Nishizaki Daisuke , Adashek Jacob J , Kato Shumei , Kurzrock Razelle
Published: February 2025

The discovery of Toll-like receptors (TLRs) and their role in dendritic cells earned the Nobel Prize for 2011 because TLRs profoundly enhanced our understanding of the immune system. Specifically, TLR3 is located within the endosomal compartments of dendritic cells and plays a crucial role in the immune response by acting as a pattern recognition receptor that detects both exogenous (viral) and endogenous (mammalian) double-stranded RNA. However, TLR3 activation is a double-edged sword in various immune-mediated diseases. On one hand, it can enhance anti-viral defenses and promote pathogen clearance, contributing to host protection. On the other hand, excessive or dysregulated TLR3 signaling can lead to chronic inflammation and tissue damage, exacerbating conditions such as autoimmune diseases, chronic viral infections, and cancer. In cancer, TLR3 expression has been linked to both favorable and poor prognoses, though the underlying mechanisms remain unclear. Recent clinical and preclinical advances have explored the use of TLR3 agonists in cancer immunotherapy, attempting to capitalize on their potential to enhance anti-tumor responses. The dual role of TLR3 highlights its complexity as a therapeutic target, necessitating careful modulation to maximize its protective effects while minimizing potential pathological consequences. In this review, we explore the intricate roles of TLR3 in immune responses across different disease contexts, including cancer, infections, autoimmune disorders, and allergies, highlighting both its protective and detrimental effects in these disorders, as well as progress in developing TLR3 agonists as part of the immunotherapy landscape.
Application of virtual planning to maxillofacial reconstruction with an implant prosthesis: a case report
Authors: Oyamada Yutaro , Yamada Hiroyuki , Miyamoto Ikuya , Kondo Hisatomo
Published: February 2025

Background

A case of postoperative mandibular defects was successfully managed using an intraoral scanner and computer-aided design/computer-aided manufacturing (CAD/CAM) technology, facilitating jaw reconstruction and functional restoration with implants for a critical mandibular defect.

Case presentation

The intraoral scanner was used to scan the maxilla and mandible, and occlusal scans were acquired. The obtained data were imported to CAD/CAM software to design the virtual teeth. Digital Imaging and Communications in Medicine data of preoperative cone-beam computed tomography images were converted to three-dimensional (3D) data using specialized software to examine the mandibular bone volume and modify the jawbone morphology. All data were superimposed on the implant simulation software, and jawbone morphology was modified considering the implant placement position. The finalized jawbone 3D data were printed using a 3D printer. Then, a titanium mesh tray was fabricated on the 3D printed model. Subsequently, iliac cancellous bone grafting using a titanium mesh tray and implant treatment were performed.

Conclusions

The application of digital technology helped visualize the final image of the treatment result and collaborate closely with the oral surgeon from the pre-reconstruction stage. This technique allows mandible reconstruction after considering the implant placement based on the ideal prosthesis.
Incorporating community perspective in research funding: creation of the National Multiple Sclerosis Society Community Review of MS Research Committee
Authors: Lampe Anna T. , Zackowski Kathleen M.
Published: February 2025

Integrating community voices in scientific research is important to ensure the research outcomes reflect what is meaningful to that community. However, the process by which individuals from the community are included in scientific grant funding decisions is variable and often comprises only a patient representative on a review panel or advisory board that is largely composed of scientific experts in the field. Finding the right balance for incorporating and honoring the scientific community’s technical expertise and the patient community’s lived expertise has been a growing discussion. The work of the National Multiple Sclerosis (MS) Society is a movement by and for all people affected by MS, meaning that the perspectives of people living with MS (MS community) are essential in all work conducted by the Society. In alignment with this, the National MS Society formed the Community Review of MS Research Committee (Committee) in 2021 to gather feedback from MS community members on research grant applications. The Committee’s feedback focuses on patient-centered concerns and relevance to the MS community. The Committee is composed of a diverse group of non-scientist individuals affected by MS that provide the Society with unique MS community-specific feedback, separate from the established scientific review committee. Here the process of identifying the goals of this Committee and planning of the processes used by the committee, as well as committee implementation, execution, and refinement over three years is described. Through feedback from this Committee, it was demonstrated that people affected by MS have important perspectives and insights into research projects focused on MS and can offer unique guidance to scientist applicants. This Committee has provided benefits to the Society, the MS community, and the Committee members themselves. In addition, the formation of this Committee has allowed the Society to be better informed about topics that are relevant to the MS community and to comprehensively and systematically incorporate the MS community’s perspectives in research grant funding decisions. This publication is intended to share learnings from the development of this Committee to be useful for other disease communities with the goal of incorporating the community voice into scientific research.
Consumer behavior and its role in E. coli outbreaks: the impact of fast-food preparation practices and hygiene awareness
Authors: Ajekiigbe Victor Oluwatomiwa , Ogieuhi Ikponmwosa Jude , Anthony Chidera Stanley , Bakare Ifeoluwa Sandra , Anyacho Sopuruchukwu , Ogunleke Praise Oluwatobi , Fatokun Damilola Ifeoluwa , Akinmeji Olufemi , Ruth Osineye Tolulope , Olaore Akintomiwa Kolawole , Amusa Oluwafemi , Agbo Chinonyelum Emmanuel
Published: February 2025

Background

The fast-food industry, a rapidly expanding business due to the influence of urbanization and busy lifestyles, has significantly shaped consumer food habits and quality food-seeking behavior. However, this fast-growing sector is frequently challenged by bacteria of clinical, microbiological, and economic importance, including Escherichia coli (E. coli). While many strains of E. coli are harmless and support digestion, pathogenic variants such as E. coli O157:H7 are responsible for severe foodborne illnesses, public health crises, and economic losses.

Main body

Our study explores consumer behavior within the fast-food industry, highlighting its role in shaping responses to E. coli outbreaks. Also, it examines how increased awareness of food safety risks has influenced consumer decisions, such as adopting hygienic practices and preferring establishments that prioritize food safety. Furthermore, the study investigates the contribution of poor fast-food preparation practices—such as undercooking and cross-contamination—to the spread of E. coli and emphasizes the critical need for improved hygiene awareness among fast-food workers. We analysed notable case studies involving E. coli outbreaks linked to fast-food chains, and subsequently identified gaps in industry practices and consumer behavior that exacerbate the risk of foodborne illnesses. This emphasizes the importance of preventive measures, including industry-driven reforms such as enhanced food handling protocols and consumer education programs, to mitigate future outbreaks.

Conclusions

This study aims to provide evidence-based insights into the shared responsibility of fast-food establishments and consumers in reducing the prevalence of E. coli infections. By addressing gaps in hygiene awareness and preparation practices, the findings emphasize the potential for collaborative efforts to strengthen public health outcomes and prevent further outbreaks.
Patient reported physical function, mental health, and treatment patterns in dermatomyositis: survey results from a cross-sectional study of adult dermatomyositis patients
Authors: Christopher-Stine Lisa , Paik Julie J. , Goriounova Alexandra S. , Mudd Paul N.
Published: February 2025

Objectives

Dermatomyositis (DM) is a rare and progressive immune-mediated disease with no cure and significant patient burden that encompasses physical, mental, and financial impacts. Patients experience debilitating symptoms that may include muscle weakness, itchy and painful rash, joint pain, and fatigue. Despite the heterogeneity of the disease and the breadth of possible symptoms, the impact of DM on a diverse range of patients’ quality of life (QoL) has not been well-characterized in literature. The aim of this study was to describe the experiences of patients living with DM as they relate to physical and mental impacts, productivity, and treatment patterns and satisfaction.

Methods

To address this deficiency, a 60-question survey was developed to capture adult patient perspectives on the impact of DM on their QoL. Members of The Myositis Association (TMA) with a self-reported diagnosis of DM who were 18–75 years old and whose disease duration was ≥ 1 year were invited to complete the online survey.

Results

Respondents were predominantly female (88%, 172/195), white (82%, 160/195), and had a median age of 57 years. Approximately 50% (98/195) of the respondents rated their overall symptoms as moderate and the three most bothersome symptoms were muscle weakness (44%, 86/195), fatigue (43%, 84/195), and muscle pain (30%, 59/195). Almost all respondents (83%, 162/195) experienced some form of mental stress due to DM and reported that this had a negative impact on interpersonal relationships. The majority (87%, 170/195) of respondents were less than satisfied with the level of support they received for DM.

Conclusions

Our study demonstrates the significant burden of DM on a patients’ QoL and there remains a large unmet need for financial support, mental health care, and improved treatment options for patients living with DM.
A multi-agent approach with verifiable and data-sovereign information flows for decentralizing redispatch in distributed energy systems
Authors: Heess Paula , Holly Stefanie , Körner Marc-Fabian , Nieße Astrid , Radtke Malin , Schick Leo , Stark Sanja , Strüker Jens , Zwede Till
Published: February 2025

The need to harness the flexibility of small-scale assets for system stabilization, including redispatch, is growing rapidly with the increasing prevalence of distributed generation, such as photovoltaic systems and heavy loads, in particular heat pumps and electric vehicles. Integrating these resources into the redispatch process presents special requirements: On the one hand, building trust with the owners of such assets requires privacy and a reasonable degree of autonomy and engagement. On the other hand, besides the system’s scalability and robustness, the verifiability and traceability of provided data are essential for grid operators who depend on the reliable provision of redispatch services. To date, research and practice have encountered significant challenges in defining a system that enables the inclusion of decentralized flexibilities while satisfying necessary requirements. To that end, we present a novel conceptual system design that addresses these challenges by combining a multi-agent system (MAS) approach with verifiable information flows through digital self-sovereign identities (SSIs) and Zero-Knowledge-Proofs (ZKPs). Single agents, as edge devices, operate locally and autonomously, respecting customer preferences, while MAS provide the ability to design robust, reliable, and scalable systems. SSI enables agents to manage their data autonomously, while ZKPs are used to protect users’ privacy through selective data disclosure which allows the verification of the correctness of information without disclosing the underlying data. To validate the feasibility of this design, a case study is included to demonstrate the functionality of key sub-processes, such as baseline optimization, aggregation, and disaggregation, in a realistic scenario. This case study, supported by a prototype implementation, provides initial evidence of the concept’s soundness and lays the groundwork for future evaluation through extensive simulations and field testing. Together, the technologies included in the conceptual system design balance full transparency for grid operators with autonomy and data economy for asset owners.
Two 3′ proximal hairpins play a key role in the replication of wheat yellow mosaic virus
Authors: Geng Guowei , Liu Minjun , Yuan Xuefeng
Published: February 2025

Wheat yellow mosaic virus (WYMV), a member of the genus Bymovirus, causes substantial losses in wheat production in East Asia, including China and Japan. Although genomic RNA replication is an important process in the viral life cycle, the independent regulation of WYMV RNA replication by its 3ʹ and 5ʹ untranslated regions (UTRs) remains unclear. In this study, we sought to analyze the core structural features of the 3ʹ UTR in the regulation of the replication of WYMV RNA1 in vitro, locate the viral RNA sites to which the NIb protein binds, and determine the regulatory effects of the VPg, P3, and 14 K proteins on NIb RNA-dependent RNA polymerase (RdRp) activity. We found that the NIb protein in WYMV RNA1 only specifically recognized its 3ʹ UTR as the core enzyme for replication. Moreover, the 14 K and P3 proteins were established to synergistically enhanc the in vitro RdRp activity of the NIb protein, whereas the VPg protein was found to play an inhibitory role. Based on RNA structure probing and mutational analysis, we identified 7624UU and 7571UU as putative sites for interaction with the NIb protein and demonstrated that replication is dependent on their coexistence. In addition, hairpins 2 and 5 of the 3' UTR were found to be essential for NIb protein replication. Collectively, the findings of our in vitro analysis of the replication regulatory elements of WYMV RNA1 3ʹ UTR, provide a basis for in vivo studies on the regulation of WYMV replication and the identification of potential targets for the prevention and control of WYMV-caused crop diseases.
Common and Rare DUOX Variants in Patients with Congenital Hypothyroidism: Case-control Study and Family-based Analysis
Authors: Jia Yaning , Wang Xiaoyu , Zhang Liqin , Duan Yanan , Zou Hui , Wang Fengqi , Liu Xiangju , Li Miaomiao , Liu Shiguo
Published: February 2025

Context

Dual oxidases (DUOXs) are essential for thyroid hormone synthesis. Rare DUOX variations have been detected in patients with congenital hypothyroidism (CH); however, their mode of inheritance and genotype-phenotype correlations remain unclear. Additionally, no study has determined whether common DUOX variants confer a risk of CH.

Objective

To elucidate the molecular and clinical characteristics of CH caused by rare and common DUOX variants.

Methods

Targeted next-generation sequencing was performed on 203 trios (parents and their child with CH) to screen for rare DUOX variants. For common variants, eight tag single nucleotide polymorphisms (SNPs) were genotyped among 298 trios and 439 healthy controls. The association between these SNPs and CH risk was analyzed using a case-control study and a family-based transmission disequilibrium test.

Results

The genetic contribution of rare DUOX variants to CH was 16.3% (DUOX2 14.3% and DUOXA2 2.0%). Familial co-segregation analysis suggested that DUOX variants were transmitted by an autosomal recessive pattern. These patients exhibited dyshormonogenesis and were more likely to develop into transient CH with the lower requirement of levothyroxine dose. Regarding common variants, five SNPs distributed across DUOXs were significantly associated with CH in both the case-control and family-based study. DUOX1 rs16939752 C>T and DUOXA1 rs3784576 C>A protected against CH, whereas DUOX2 rs269868 A>G, rs2001616 A>G and DUOXA2 rs2252371 T>C were associated with increased susceptibility to CH.

Conclusion

Our research confirmed that DUOX variants are inherited in an autosomal recessive manner. We present a comprehensive spectrum of rare and common DUOX variants that provides more accurate insights into the pathogenesis of CH associated with DUOX.
The Necromantic State
Authors: Troconis Irina R.
Published: February 2025

In the spring of 2013, televisions across Venezuela announced the death of then-president Hugo Chávez, leader of the Bolivarian Revolution and key political actor in Latin America’s “turn to the left.” Chávez’s death, however, was not the end of Chávez’s life. In The Necromantic State, Irina R. Troconis examines how Chávez, as a “specter,” has lingered in Venezuela’s public, private, and digital spaces. Focusing on contemporary Venezuela and drawing from a diverse corpus that includes tattoos, toys, memes, graffiti, and a hologram haunting the streets of downtown Caracas, Troconis contends that, in moments of failed transitions, political tensions, and crises of legitimacy, the state brings the dead back to life to negotiate the terms of its survival. By showing how this necromantic performance enables the state’s material and visual manifestations in public and private spaces, Troconis untangles a sociopolitical moment in which the ghostly acts as the affective, social, and political force that grounds state authority and ensures the preservation of the status quo, as it circumscribes acts of political imagination and limits popular resistance.
Alveolar epithelial paxillin in postnatal lung alveolar development
Authors: Scheer Mikaela , Kyi Priscilla , Mammoto Tadanori , Mammoto Akiko
Published: February 2025

Focal adhesion protein, paxillin plays an important role in embryonic development. We have reported that paxillin controls directional cell motility and angiogenesis. The role of paxillin in lung development remains unclear. Paxillin expression is higher in mouse pulmonary alveolar epithelial type 2 (AT2) cells at postnatal day (P)10 (alveolar stage) compared to P0 (saccular stage). The alveolar and vascular structures are disrupted, lung compliance is reduced, and the postnatal survival rate is lower in tamoxifen-induced PxniΔAT2 neonatal mice, in which the levels of paxillin in AT2 cells are knocked down. Surfactant protein expression and lamellar body structure are also inhibited in PxniΔAT2 neonatal mouse lungs. The expression of lipid transporter ABCA3 and its transcriptional regulator CEBPA that control surfactant homeostasis is inhibited in PxniΔAT2 neonatal mouse AT2 cells. These findings suggest that paxillin controls lung alveolar development through CEBPA-ABCA3 signaling in AT2 cells. Modulation of paxillin in AT2 cells may be novel interventions for neonatal lung developmental disorder.
Travelling through time with Disease Models & Mechanisms
Authors: Adhikari Saanjbati , Hackett Rachel
Published: February 2025

Summary: This year, The Company of Biologists − publisher of Disease Models & Mechanisms (DMM) − is celebrating its 100-year anniversary. In 2025, we discuss DMM's journey since its launch in 2008.
Substandard Reinforced Concrete Walls with Rectangular Cross-section: Assessment of Shear Resistance
Authors: Moretti Marina
Published: February 2025

Reinforced concrete walls in buildings constructed prior to 1990 possess low shear resistance and their reinforcement detailing differs considerably as compared to similar walls in modern buildings, designed according to modern code principles. For the seismic capacity assessment of older buildings the correct estimation of shear resistance of existing RC walls is crucial. In previous research it has been demonstrated that available design models are not capable of reliably predicting the shear resistance of RC walls with reinforcement different than the one prescribed by modern codes. In this paper, a design model is presented for the assessment of shear resistance of RC walls with rectangular section, irrespective of reinforcement configuration. The model includes the contribution of all major mechanisms to shear resistance, namely: the longitudinal reinforcement of the confined regions at either end of the cross-section, the horizontal and vertical web reinforcement, the axial compressive force, and the concrete strut. The proposed equations have no restrictions in their applicability, in contrast to the majority of existing models, and proved to be the most effective in assessing the shear resistance of 129 tested RC walls, among 14 other design models considered, including existing design codes. Indicative examples are provided to demonstrate the better predictive capacity of the proposed equations.
The genome sequence of the American mink, Neogale vison (Schreber, 1777)
Authors: O’Brien Michelle F. , Lopez Colom Rosa ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: February 2025

We present a genome assembly from a female specimen of the American mink, Neogale vison (Chordata; Mammalia; Carnivora; Mustelidae). The assembly comprises two haplotypes, with total lengths of 2,697.13 megabases and 2,662.78 megabases, respectively. Most of haplotype 1 (98.72%) and haplotype 2 (98.73%) is scaffolded into 15 chromosomal pseudomolecules, including the X chromosome. The mitochondrial genome has also been assembled, with a length of 16.59 kilobases.
Co kryje się w sieci? Negatywne zachowania w Internecie
Authors: Jachym Wioletta
Published: February 2025

Celem artykułu jest przedstawienie zagadnień związanych z negatywnymi zjawiskami w Internecie, których doświadczają jego użytkownicy. W pierwszej części opracowania podjęto próbę charakterystyki cyberprzemocy i phishingu. Opracowanie zawiera omówienie wskazanych zjawisk oraz prezentację wyników badań empirycznych przeprowadzonych w tym zakresie. Zwróconouwagę na dwa aspekty – doświadczenie cyberprzemocy w grupie studentów i poziom wiedzy osób biorących udział w badaniach dotyczących zagadnienia phishingu. Wyniki przeprowadzonych badań potwierdzają, że cyberprzemoc jest zjawiskiem powszechnym i przykłady jego wystąpienia są znane w grupie studentów biorących udział w badaniach. Phishing również jest rozpoznawalnyw grupie badawczej, ale uczestnicy badania mają zróżnicowaną wiedzę na temat tego, w jaki sposób zapobiegać phishingowi i gdzie się zgłosić w sytuacji jego wystąpienia.
Performance improvement and mechanisms of fused silica-based SiO2 coating by conditioning by CO2 laser
Authors: Han Jinghua , He Changtao , Li Yaguo , Xiong Lingling , Zhou Guori , Liu Kai
Published: February 2025

In this study, a continuous wave CO2 laser was used to process silicon dioxide (SiO2) anti-reflection (AR) films coated on a fused silica substrate by the sol-gel method. The effects of laser conditioning on the properties of AR coatings at 1064 nm were investigated to determine the relationship between laser power and coating properties. The structural and mechanical properties of the processed films were measured by FTIR, UV-Vis spectroscopy, and nanoindentation. After laser conditioning, it was found that the mechanical strength of the coating improved, the roughness of the coating reduced to 9.7 nm, and the laser-induced damage threshold (LIDT) of the coating at 1064 nm wavelength increased to 7 J/cm2.
Solid-state far-field Macroscopic Fourier ptychographic imaging via programmable illumination with spatial light modulator
Authors: You Di , ge ren , Ma Haotong
Published: February 2025

Accurate angle-varied illumination can be easily implemented in various ways for Fourier ptychographic microscopy (FPM). However, it is quite challenging at a long distance for far-field macroscopic Fourier ptychography (FP). In this work, we present a novel illumination scheme for macroscopic FP using spatial light modulator to programmatically modulate the coherent illumination light, which could provide flexible and accurate angle-varied illumination at a relatively long distance. Compared with the existing macroscopic FP illumination methods, it dose not need any bulky mechanism to drive laser scanning, thus improving data collection efficiency, and can also freely adjust the illumination spot size through phase coding to avoid the issues of limited field of view and excessive dispersion of illumination energy. Finally, the illumination scheme is combined with a single camera to form a new solid-state macro FP approach, which is validated experimentally through various everyday objects and USAF target at lab-scale range. And the experimental results confirm its suitability and effectiveness for macro FP imaging.
Vascular E-selectin Expression Recognized by the U12-12 Monoclonal Antibody as a Predictive Marker for Steroid Resistance in Immune Checkpoint Inhibitor-related Colitis
Authors: Nakashima Koki , Nagaya Tadanobu , Iwaya Mai , Hiramatsu Katsushi , Uehara Takeshi , Nakamoto Yasunari , Ishizuka Tamotsu , Kobayashi Motohiro
Published: February 2025

In immune checkpoint inhibitor (ICI)-related colitis, tumor necrosis factor (TNF)-α blockade is recommended if symptoms are not alleviated with corticosteroids. Although TNF has been shown to be associated with steroid resistance, the early prediction of steroid resistance is challenging in clinical practice. Therefore, in the present study, we evaluated the potential of vascular E-selectin expression, which is induced by TNF, to serve as a predictor of steroid resistance in ICI-related colitis. We performed immunohistochemical analysis of 29 cases of ICI-related colitis using the U12-12 monoclonal antibody, which specifically recognizes E-selectin, and examined the association between U12-12 staining and clinical features. The result showed that the proportion of steroid-resistant cases was significantly higher in the U12-12-positive group (8 of 9 cases; 88.9%) than in the U12-12-negative group (1 of 20 cases; 5.0%) ( p<0.001). Furthermore, the proportion of steroid-resistant cases was 100% (6 of 6 cases) in patients with U12-12-positive and Common Terminology Criteria for Adverse Events (CTCAE) grade 3 or higher and 0% (0 of 12 cases) in patients with U12-12-negativity and CTCAE grade 1 or 2. Thus, evaluation of vascular E-selectin expression using the U12-12 monoclonal antibody is useful for predicting steroid resistance in ICI-related colitis.
Reading Eliot’s Four Quartets: Focusing on God’s Providence to Save Humanity, the Moving Principle of the Universe, and Calling.
Authors:   The T. S. Eliot Society Of Korea, LEE Cheolhee
Published: February 2025

Most researchers admit that Eliot’s Four Quartets is largely based on Christianity. Certainly Eliot also admits that. The key of Christianity is God’s Providence, which all things are moved by His will. That is, the master of all things is God, not a human. The problem is that human beings don’t know all of God’s will. Resultingly, human’s duty is to obey it. Eliot shows it very well through the Four Quartets. In short, human beings cannot control all things in the universe. Also God recalled human beings in order to achieve His will. Thus human’s life must be guided by it. Eliot, practically, demands that we should go into a timelessness distinct from physical times, abstaining from worshipping the material world, and acting on spirituality, not materiality. Eliot shows it effectively through Four Quartets.
Peran komitmen organisasi sebagai pemediasi hubungan antara kompensasi, motivasi, dan kinerja pegawai
Authors: Nur Shania Ayanda , Harsono Soni , Prawitowati Tjahjani
Published: February 2025

This study analyzes the role of organizational commitment as a mediator between compensation, motivation, and performance of PPNPN employees at the Pusdatin of the Ministry of ATR/BPN, with a sample of 48 employees using a saturated sampling technique. The role of PPNPN is important to study because it will be able to explain its contribution to the performance of government agencies because PPNPN performance is measured through plans and performance targets made by employees and must be achieved within a certain period of time or what is commonly referred to as Employee Performance Targets (SKP). Performance targets made at the beginning of the year will then be assessed at the end of the year and their compliance with the predetermined targets will be assessed. The analysis technique used is SEM-PLS with the WarpPLS 8.0 program, and data was collected through a Google Form questionnaire. The results of the study indicate that compensation does not have a significant effect on employee performance, while motivation and organizational commitment have a significant positive effect on performance. Organizational commitment also mediates the effect of compensation and motivation on employee performance. The implication of this study is the importance of programs to improve organizational commitment and PPNPN motivation in order to encourage employee performance.
Analisis faktor penentu keberhasilan implementasi sistem informasi akademik pada ISB Atma Luhur
Authors: Amri Amri , Isnanto R Burham , Alkodri Ari Amir , Bakti Atmaja R Ferry
Published: February 2025

To support higher education, academic information systems are required. However, user satisfaction, especially among students, is crucial to the system’s success. The aim of this research was to investigate the relationship between student happiness and the quality of academic information systems at the Atma Luhur Institute of Science and Business (ISB), using ease of use as a mediating variable. This study aims to analyze the factors influencing student satisfaction with the academic information system at ISB Atma Luhur. Using structural equation modeling (SEM) with a partial least squares (PLS) approach, this research examines the impact of information quality, system quality, and service quality on ease of use and student satisfaction. Data were collected through questionnaires distributed to 200 students who use the information system. The results indicate that information quality and system quality significantly affect ease of use, which in turn affects student satisfaction. Additionally, service quality has a direct and significant impact on student satisfaction. These findings contribute significantly to the development of academic information systems by highlighting aspects that need attention to enhance user satisfaction. The practical implications of this research include recommendations for improving information quality, system quality, and service quality within the context of academic information systems.
Peran bias perilaku investor dalam proses pengambilan keputusan dan kinerja investasi
Authors: Anwar Roseline Mannuela , Wijaya Hendry , Amelinda Rita
Published: February 2025

This study aims to determine whether investor bias, including heuristic and herding biases, has an impact on investors’ investment behaviour, particularly in Indonesia. The sample was taken by purposive sampling, which is a non-probability sampling technique. This technique is used to identify respondents who have already made stock investments on the stock exchange. This study used 154 investor respondents, specifically those who started investing in stock from various range of age. The study employs path analysis using the Smart-PLS software tool for data analysis. The results of this study show that heuristic bias is proven to have a significant positive effect on investors’ investment decisions and performance. Furthermore, investment decisions are proven to mediate the effect of heuristic bias on investor investment performance. On the other hand, herding bias is not proven to have an effect on investor investment decisions and performance. In addition, investor investment decisions are also not proven to mediate the effect of herding bias on investor investment performance. Based on the results of this study, investors need to be aware of the role of heuristic bias to make more rational decisions that can ultimately improve investor investment performance.
The effect of perceived benefits,ease of use, and risk on culinary MSMEs’ interest in utilizing QRIS
Authors: Rahmawati Fitri , Merlinda Santi
Published: February 2025

The GNNT (National Non-Cash Movement) program is in line with fintech innovations that have a real impact on improving the efficiency of the payment system, financial inclusion, and the Indonesian economy. In the Kedungkandang sub-district area of Malang City, the number of culinary MSME units has increased, which can encourage GNNT to be realized. However, many culinary MSMEs have not optimized using QRIS as a non-cash payment tool. This study aims to see the effect of perceived benefits, ease of use, and risk on culinary msmes’ interest in utilizing QRIS. This research uses Quantitative method approach in this research. Culinary MSMEs are in Kedungkandang District, Malang City, as the research population. The sample was taken by a purposive sampling technique with a research sample of 100 respondents. Data ere collected by n distributing questionnaires and was measured using nominal and Likert scales-data processing with Stata 17 software with a multinomial logistic regression model. The results show that perceived benefits, convenience and risk partially affect the interest of culinary MSMEs in using QRIS. The perception of benefits, convenience and risk encourages an increase in the probability of interest in culinary MSMEs in using QRIS so that perceived benefits can increase MSME understanding of the benefits of QRIS, the perception of ease of use supports increased adoption of QRIS use; perceived risk can encourage strengthening the QRIS security system so that MSMEs are more confident and adopt QRIS.
Justification of the reciption component of plants in the production of functional food products
Authors:   Orel State University named after I.S. Turgeneva, Ivanova Tamara , Simonenkova Anna ,   Orel State University named after I.S. Turgeneva, Evdokimov Nikita ,   Orel State Agricultural University named after N.V. Parakhina
Published: February 2025

Despite significant advances in the pharmacotherapy of a number of non-communicable diseases (NCDs) of the respiratory tract, important attention should be paid to nutrition as one of the links in complex therapy. Reflecting the global consumer trend of health promotion, it is shown that increasing the production of functional consumer products aimed at promoting a healthy diet can play a certain role in preventing the development of NCDs.
A promising direction is the use of medicinal plants in food production, since many plants con-tain biologically active substances, flavonoids, essential oils, organic acids, vitamins, minerals, dietary fiber and other important nutrients, and through them the need can be largely satisfied the human body in substances that differ in nutritional value and biological activity. For use as ingredients in the development of dietary supplements for the fortification of food products, the creation of functional and specialized products, it is necessary to be guided by TR CU 021/2011, which provides a list of plants and their processed products prohibited for use in die-tary supplements. The purpose of the study is to substantiate the prescription-component com-position of dietary supplements from medicinal plant raw materials, approved for use. We have studied the antioxidant properties of medicinal plants, which have properties recommended for the prevention of diseases in the respiratory tract – fennel, caraway seeds, calamus rhizomes. It has been shown that caraway seeds have the highest antioxidant activity (77.2 %), the lowest activity was found in fennel fruits (29.1 %). A recipe-component composition of a mixture for a drink for the prevention of upper respiratory tract diseases has been proposed.
Determination of rational parameters of the drum mixer operation when receiving bulk products
Authors:   Russian State Agrarian University – Moscow Timiryazev Agricultural Academy, Borodulin Dmitriy , Sukhorukov Dmitriy ,   Kemerovo State University, Suvorova Yulia ,   Kemerovo State University
Published: February 2025

The mixing process is widely used in various areas of production: for the manufacture of various types of products and semi-finished products, such as agricultural mixtures, suspensions, bone cements and others. This process is the movement of particles of bulk material components in the space of the mixed volume. Various types of mixing apparatus are used to move the components. One of the most common mixers are continuous drum type mixers. An important problem that needs to be dealt with when developing a mixer design is reducing the coefficient of heterogeneity of the resulting mixture. The heterogeneity of the granular mixture is associated with different physical and chemical properties of the components of which it consists. These include density, flowability, viscosity, etc. The object of study is a new design of a drum mixer with an internal drum. The subject of the study is the design features of this mixer, including the length of the inner drum, the angle of inclination of the drum and the frequency of its rotation. These design features affect the final state of the mixture. Experiments conducted with various indicators of the mixer operating parameters helped to identify the most optimal values of these parameters, at which the value of mixture heterogeneity is minimal. A total of 27 experiments were carried out. For clarity, all results are presented in the form of graphs. The graphs show that the optimal value of the parameters is: the length of the internal drum generatrix is 0.6 meters, the angle of inclination of the apparatus is α = 5° and the drum rotation speed is n = 45 rpm. At these values, the heterogeneity of the mixture is minimal, V_c = 9.63 %.
Unshackle Pseudomonas putida GN1 and organic amendments against root rot (Macrophomina phaseolina) and stem rot (Sclerotium rolfsii) control by plant growth promotion in groundnut
Authors: Paramasivan M , Binodh A K , Rajendran L , Ramjegathesh R , Indiragandhi P , Thangam A , Karthikeyan M , Johnson I , Sheela J
Published: February 2025

The efficacy of Pseudomonas putida (GN1) and Burholderia cepacia (KKM1) as seed treatment and soil application along with neem cake against groundnut root rot and stem rot disease was evaluated under rainfed conditions during the years 2021, 2022 and 2023. The present study is to evaluate biocontrol agents and organic amendments against Macrophomina phaseolina and Sclerotium rolfsii in peanut. The result showed that neem cake (10 %) recorded the maximum inhibition of Macrophomona phaseolina (40.91 %) and S. rolfsii (45.45 %) under in vitro whereas neem cake combined with P. putida and B. cepacia as seed treatment 10 g/kg of seed and soil Application of P. putida @ 2.5 kg + Neem cake 150 kg/ha decreases the soil-borne diseases of root rot (71.70 %) and stem rot (64.88 %) and also increased the yield 2130.48 kg/ha with the cost-benefit ratio of 2.74 under rainfed field conditions comparing to other treatments. In addition, the same treatment increased the total root length (2110.41 mm), Root tips (573 Nos), forks (501 Nos), Maximum diameter (18.11 mm) and estimated volume (27170 cm3 ) when using BioVis PSM Root -Rhizoscanner.
Morphological and molecular characterization of Chnoospora minima (Scytosiphonaceae, Ectocarpales) along Mexican coasts, with the description of C. ramosissima sp. nov.
Authors: Núñez Resendiz María Luisa , Dreckmann Kurt M. , Hernández Oscar E. , Palma-Ortíz Carlos Adán , Sentíes Abel
Published: February 2025

Chnoospora is one of the genera in Scytosiphonaceae with many taxonomic changes, comprising only two currently taxonomically accepted species. Chnoospora minima, its type species, has the widest distribution range and is characterized by a simple morphology with cylindrical or flattened thalli and dichotomous branching. On the Mexican coasts, its distribution is disjunct, being recorded on both the Pacific and Atlantic sides. In the present study we aim to characterize morphologically and molecularly the Mexican populations of C. minima. Our results revealed two phylogenetically independent groups, corresponding with different species with sympatric distribution in the tropical Mexican Pacific, C. minima and C. ramosissima sp. nov. Chnoospora ramosissima has the typical morphology of the genus, however, it is distinct in having relatively constant length of the branching segments, that are gradually reducing towards the apical portions, giving the thallus a profusely branched appearance; in addition, cellular measurements also differ between them. In contrast, C. minima, presented five different morphotypes on the Mexican coasts, however, all of them were different from C. ramosissima by having a central branching segment longer than the rest, subsequently reducing towards the apical portions, giving the thallus the appearance of being elongated and little branched.
AI-based prediction of transmission quality in cognitive optical networks
Authors: Patil Shankar M. , Satre Shilpa M. , Chavan Gurunath T. , Kharade Prakash A.
Published: February 2025

Quality of Transmission (QoT) prediction is done by a proposed method in optical networks. It uses a Radial Basis Function Network (RBFN) model trained with data from a comprehensive optical model. The RBFN model is enhanced with several techniques to improve its accuracy. The key objective is to enhance hardware utilization by significantly reducing the required system margin, potentially up to the order of dBs. To achieve this, the study employs the Radial Basis Function Network (RBFN) model, capitalizing on input data related to connectivity and signal characteristics for QoT prediction. The proposed method achieves good performance (MSE: 0.802, MAE: 0.2) but is slower than some existing methods. However, compared to these existing methods, the proposed method has 1.54 %, 5.32 %, and 5.46 % higher performance than SOM-RBF, AHFSE, and Wavelet-chaos NN. This research also contributes to the field by introducing a new cognitive-based QoT model that uses deep learning techniques. The study showcases the potential for practical implementation and optimization in relevant applications, emphasizing the intersection of artificial intelligence and optical network resource utilization.
Replication and methodological robustness in quantitative typology
Authors: Becker Laura , Guzmán Naranjo Matías
Published: February 2025

Replication and replicability are fundamental tools to ensure that research results can be verified by an independent third party, reproducing the original study and ideally finding similar results. Yet, replication has not played a very important role in language typology so far, with most of the discussion around replication concerned with different types of language samples and sampling methods. This study addresses the issue of replication in typology in a different way. We use the original datasets of four previous typological studies (Berg 2020; Dryer 2018; Seržant 2021; Shcherbakova et al. 2023) to show how statistical modeling can be used to test methodological robustness in typology. We do so employing advanced statistical bias controls, namely phylogenetic regression for genetic effects and a Gaussian Process for contact effects. While we could replicate some of the original results, parts of our findings differed from the original ones, revealing important methodological insights. Our comparisons show that more advanced statistical techniques that can model the phylogenetic and contact relations between languages pick up more complex patterns in the data than traditional sampling methods, and they capture more of the real relations between languages and their effects on linguistic structure.
The cognitive processing of nouns and verbs in second language reading: an eye-tracking study
Authors: Jiang Jiayi , Huang Lingshan
Published: February 2025

This study explores the cognitive processing of nouns and verbs in second language (L2) reading, aiming to investigate the potential differences and their effects on comprehension performance. Twenty-five Chinese students read an English text while their eye movements were recorded. A reading comprehension test evaluated the participants’ L2 reading comprehension performance. The results reveal a significant difference in total reading time between nouns and verbs. Additionally, total reading time, gaze duration, and the number of fixations on both nouns and verbs are negatively correlated with L2 reading comprehension performance. These findings suggest that while the initial processing mechanisms of nouns and verbs may be similar, they diverge in late stages of processing.
Effect of sandblasting and aging on structural and mechanical properties of Inconel 625 coated steels for marine applications
Authors: Durmuş Hülya , Çömez Nilay , Gül Canser
Published: February 2025

In present study, the Inconel 625 alloy was coated using TIG welding method, and the coating was subjected to sandblasting and artificial aging. The coating samples were examined by wear and corrosion tests to evaluate their performance in marine applications. The study characterized different sample groups for the purposes of coating steel samples, coating surfaces by deformation, applying aging processes, and observing the combined effects of aging and deformation. Wet-sliding wear and corrosion tests were conducted in 3.5 wt.% NaCl solution. The presence of compressive stresses resulting from sandblasting and aging led to microstructural changes, while formation of δ, γ′, γ″ phases and complex carbides contributed to increased wear and corrosion resistance. Deformation supported the precipitation of γ′, γ″ phases and carbides. Aging increased the hardness by 30 %, whereas the sandblasting process doubled up the hardness of as-deposited coating. Maximum corrosion resistance was obtained in the aged sample without applying sandblasting.
Raw Materials and Technological Choices: Case Study of Neolithic Black Pottery From the Middle Yangtze River Valley of China
Authors: Li Guoyuan , Tian Hui , Li Qiang , Shan Siwei , Zhao Jing , Li Tao
Published: February 2025

Neolithic black pottery from continental Eurasia has attracted scholarly interest since the 1930s, yet its diverse production and use remains poorly understood. This study examined 165 black pottery sherds from Fenghuangzui, a walled town in the middle Yangtze River valley of China, to investigate raw materials and technological choices during the Upper Qujialing (5300–4500 cal BP) and Shijiahe (4500–4200 cal BP) periods. Raman analysis confirms that carbon black was the sole colorant, formed through the absorption of carbon particles. Microscopic examinations categorized 104 fine-paste sherds into 4 sub-groups based on surface texture, identifying 3 clay sources (AA, BB, and BB*) through chemical analysis. AA and BB were the primary sources during both periods, while BB and BB* were preferred in the Shijiahe period for higher-quality serving and drinking vessels linked to feasting. Thin-section petrography and thermal expansion curves indicate the use of local raw materials and firing temperatures of 820–920°C. The consistent clay sources and firing conditions suggest stable practices, while the correlation between certain clay sources and finer pots indicates the potter’s adaptability to specific needs, reflecting the active role of Fenghuangzui inhabitants in sociopolitical events during the Shijiahe period.