bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Hantavirus N Protein Intracellular Dynamics and Localization
Authors: Welke Robert-William , Sperber Hannah Sabeth , Bergmann Ronny , Koikkarah Amit , Menke Laura , Sieben Christian , Krüger Detlev H. , Chiantia Salvatore , Herrmann Andreas , Schwarzer Roland
Published: February 2022

Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation, and several other crucial processes during hantavirus infection. In this study, we generated fluorescently tagged N protein constructs derived from Puumalavirus (PUUV), the dominant hantavirus species in Central, Northern, and Eastern Europe. We comprehensively characterized this protein in the rodent cell line CHO-K1, monitoring the dynamics of N protein complex formation and investigating co-localization with host proteins as well as the viral glycoproteins Gc and Gn. We observed formation of large, fibrillar PUUV N protein aggregates, rapidly coalescing from early punctate and spike-like assemblies. Moreover, we found significant spatial correlation of N with vimentin, actin, and P-bodies but not with microtubules. N constructs also co-localized with Gn and Gc albeit not as strongly as the glycoproteins associated with each other. Finally, we assessed oligomerization of N constructs, observing efficient and concentration-dependent multimerization, with complexes comprising more than 10 individual proteins.
T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
Authors: Laban Natasha Makabilo , Goodier Martin Rhys , Bosomprah Samuel , Simuyandi Michelo , Chisenga Caroline , Chilyabanyama Obvious Nchimunya , Chilengi Roma
Published: February 2022

Cellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web of Science, and Global Health databases using a combination of “t-cell”, “rotavirus” and “child” keywords to extract data from relevant articles published from January 1973 to March 2020. Only seventeen articles were identified. Rotavirus-specific T-cell immunity in children develops and broadens reactivity with increasing age. Whilst occurring in close association with antibody responses, T-cell responses are more transient but can occur in absence of detectable antibody responses. Rotavirus-induced T-cell immunity is largely of the gut homing phenotype and predominantly involves Th1 and cytotoxic subsets that may be influenced by IL-10 Tregs. However, rotavirus-specific T-cell responses in children are generally of low frequencies in peripheral blood and are limited in comparison to other infecting pathogens and in adults. The available research reviewed here characterizes the T-cell immune response in children. There is a need for further research investigating the protective associations of rotavirus-specific T-cell responses against infection or vaccination and the standardization of rotavirus-specific T-cells assays in children.
Understanding Rotavirus Vaccine Efficacy and Effectiveness in Countries with High Child Mortality
Authors: Varghese Tintu , Kang Gagandeep , Steele Andrew Duncan
Published: February 2022

Rotavirus claims thousands of lives of children globally every year with a disproportionately high burden in low- and lower-middle income countries where access to health care is limited. Oral, live-attenuated rotavirus vaccines have been evaluated in multiple settings in both low- and high-income populations and have been shown to be safe and efficacious. However, the vaccine efficacy observed in low-income settings with high rotavirus and diarrheal mortality was significantly lower than that seen in high-income populations where rotavirus mortality is less common. Rotavirus vaccines have been introduced and rolled out in more than 112 countries, providing the opportunity to assess effectiveness of the vaccines in these different settings. We provide an overview of the efficacy, effectiveness, and impact of rotavirus vaccines, focusing on high-mortality settings and identify the knowledge gaps for future research. Despite lower efficacy, rotavirus vaccines substantially reduce diarrheal disease and mortality and are cost-effective in countries with high burden. Continued evaluation of the effectiveness, impact, and cost–benefit of rotavirus vaccines, especially the new candidates that have been recently approved for global use, is a key factor for new vaccine introductions in countries, or for a switch of vaccine product in countries with limited resources.
Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies
Authors: Nickel Olaf , Rockstroh Alexandra , Borte Stephan , Wolf Johannes
Published: February 2022

Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly effective in preventing hospital admission, need for intensive care treatment and high mortality in the current SARS-CoV-2 pandemic. Lateral flow immune assays (LFIAs) offer a simple and competitive option to monitor antibody production after vaccination. Here, we compared the diagnostic performance of three different lateral flow assays in detecting nucleocapsid protein (NP), S1 subunit (S1) and receptor binding domain (pseudo)-neutralizing antibodies (nRBD) in sera of 107 health care workers prior (V1), two weeks (V2) after first vaccination with BNT162b2 as well as three weeks (V3) and eight months later (V4). In sera at V1, overall specificity was >99%. At V3, LFIAs showed sensitivities between 98.1 and 100%. The comparison of S1 and nRBD LFIA with S1 ELISA and a focus reduction neutralization assay (FRNT) revealed high concordance at V3. Thus, the use of lateral flow immunoassays appears to have reasonable application in the short-term follow-up after vaccination for SARS-CoV-2.
Essential Workers’ COVID-19 Vaccine Hesitancy, Misinformation, and Informational Needs in the Republic of North Macedonia
Authors: Fucaloro Stephen P. , Yacoubian Vahe S. , Piltch-Loeb Rachael , Harriman Nigel Walsh , Burmaz Tea , Hadji-Janev Metodi , Savoia Elena
Published: February 2022

The COVID-19 pandemic has resulted in over 5.2 million deaths. Vaccine hesitancy remains a public health challenge, especially in Eastern Europe. Our study used a sample of essential workers living in the Republic of North Macedonia to: (1) Describe rates of vaccine hesitancy and risk perception of COVID-19; (2) Explore predictors of vaccine hesitancy; and (3) Describe the informational needs of hesitant and non-hesitant workers. A phone survey was administered in North Macedonia from 4–16 May 2021. Logistic regression explored associations of COVID-19 vaccine hesitancy with sociodemographic characteristics, non-COVID-19 vaccine hesitancy, previous diagnosis of COVID-19, and individual risk perception of contracting COVID-19. Chi-squared analyses compared differences in informational needs by hesitancy status. Of 1003 individuals, 44% were very likely to get the vaccine, and 56% reported some level of hesitancy. Older age, Albanian ethnicity, increased education, previous COVID-19 diagnosis, acceptance of other vaccines, and increased risk perception of COVID-19 infection were negatively associated with vaccine hesitancy. Results indicated significant differences in top informational needs by hesitancy status. The top informational needs of the hesitant were the freedom to choose to be vaccinated without consequences (57% vs. 42%, p < 0.01) and that all main international agencies recommended the vaccine (35% vs. 24%, p < 0.01).
Revisiting the Indus Basin Model for an Energy Sustainable Pakistan
Authors: Hashmi Abrar , Bhatti Aamer Iqbal , Ahmed Saira , Tariq Muhammad Atiq Ur Rehman , Savitsky Andre
Published: February 2022

Water is vital and an essential entity directly and indirectly for all living creatures from their birth, whereas electrical energy has a dominant role in the growth of society in general and for human beings in particular. Optimal use of water and production of electrical energy at minimum cost are potential research challenges. Hydraulic energy is one of the cheapest and the most exploited renewable energy resource for power generation worldwide, and is in line with the seventh United Nations Sustainable Development Goal (SDG 7). The Indus basin is a trans-boundary basin, and its modeling has been a source of interest for scientists and policymakers. Indus Basin Model Revised (IBMR) has many variants, all focusing on optimal use of water for irrigation purposes. In this paper, the modified IBMR model is proposed addressing both agriculture and power generation aspects simultaneously. This model optimizes the Consumer Producer Surplus (CPS) by considering different water inflow probabilities. A parameter has been introduced in the modified objective function to manipulate the supply of water to agriculture and hydropower generation. The proposed model has been implemented in Generic Algebraic Modeling System (GAMS) and case studies have been investigated in presence and absence of power generation. The results obtained show that, with incorporation of hydropower, basin wide income is increased up to 11.83% using 50% exceedance probability, and results are in agreement with reference power generation estimated by National Transmission and Dispatch Company (NTDC). The SDG 7 targets ensure the reasonable, dependable, sustainable and contemporary energy access to all. The current research is focusing on how Pakistan would achieve the SDG 7 targets. By 2040, it is anticipated that Pakistan’s energy mix will have around 40% of hydropower and 16% of renewable energy.
Experiments on the Sinking of Marine Pipelines on Clayey Soils
Authors: Mendoza Edgar , Neves María G. , Afonso Cristina , Silva Rodolfo , Ramos André , Losada Miguel
Published: February 2022

An experimental study was carried out to investigate seabed-pipeline interactions with regard to soil liquefaction. For a soil with a high proportion (30 to 60%) of fine sediment, four groups of tests were configured to reproduce soil liquefaction around pipelines for different initial pipe depths, pipe densities and wave conditions (wave height and period). The study focused on verifying the theoretically computed areas of soil failure by analyzing the sinking depths of the pipelines. The main findings are that a pipe with a submerged specific weight of less than half that of the soil will move up to the mudline; that the loss of soil loading capacity is more frequently evidenced in a fluid-like behavior of the soil than by an abrupt breaking of the soil matrix; and that the pipes which are totally buried will sink more than half-buried pipes. Moreover, wave action and the specific weight of the pipes seem to play more important roles in the expected behavior of the wave–soil–pipe interaction than the initial water content of the mud.
Laboring to Conceive: Reducing Barriers to Fertility Care for Same-Sex Mothers Pursuing Parenthood
Authors: Richburg Caroline E. , Jackson Levin Nina , Moravek Molly B.
Published: February 2022

Infertility clinics and providers in the United States have made efforts to become LGBTQ-inclusive, yet patients in same-sex partnerships continue to face disproportionate barriers to accessing fertility services when pursuing parenthood. This narrative case study of a same-sex couple’s “labor to conceive” illustrates some of the structural barriers to family building that lesbian mothers face when seeking fertility care, including insurance coverage of fertility treatments, federal regulations for sperm donation, and legal definitions of parenthood. Exclusionary medical and legal systems are discussed, as are the informal strategies that this same-sex couple utilized to negotiate and circumvent these barriers. A patient-centered model of advocacy that facilitates access to and protection of same-sex partners seeking (in)fertility services is presented. Intervention points at the (1) Logistical and (2) Societal levels are considered with respect to three domains of same-sex reproduction: (A) insurance; (B) sperm donation; (C) legal adoption.
Coming Out Strategies on Social Media among Young Gay Men in Malaysia
Authors: Jerome Collin , Hadzmy Ahmad Junaidi bin Ahmad
Published: February 2022

Social media have afforded many young gay men the opportunity to explore their identities and practice coming out. The ease of use and the anonymity that can be assumed online has enabled young gay men to come up with different strategies of self-disclosure in social media. The present study seeks to examine these strategies among young gay men in Malaysia, given the limited data on the social media experiences of gay men in the country. In-depth interviews were conducted with six young, gay-identified men to find out the strategies they employed in disclosing their sexual identity online. The analysis of the interview data revealed that the coming-out strategies among the participants mostly resembled those employed by gay men in Western societies, including being out and proud, being out and discreet, and being closeted on social media. The analysis also revealed that the participants held different views regarding the role of social media in the coming out process for gay men in Malaysia. These findings have implications that are relevant to the issues of identity formation among gay men in contexts where homosexuality is still subject to social, legal, and religious condemnation.
Flexible Vertex Engineers the Controlled Assembly of Distorted Supramolecular Tetrahedral and Octahedral Cages
Authors: Bao Shu-Jin , Xu Ze-Ming , Yu Tian-Chen , Song Ying-Lin , Wang Heng , Niu Zheng , Li Xiaopeng , Abrahams Brendan F. , Braunstein Pierre , Lang Jian-Ping
Published: February 2022

Designing and building unique cage assemblies attract increasing interest from supramolecular chemists but remain synthetically challenging. Herein, we propose the use of a flexible vertex with adjustable angles to selectively form highly distorted tetrahedral and octahedral cages, for the first time, in which the flexible vertex forms from the synergistic effect of coordination and covalent interactions. The inherent interligand angle of the vertex can be modulated by guest anions present, which allows for the fine-tuning of different cage geometries. Furthermore, the reversible structural transformation between tetrahedral and octahedral cages was achieved by anion exchange monitored by mass spectrometric technique, the smaller anions favoring tetrahedral cages, while the larger anions supporting octahedral cages. Additionally, the KBr-based cage thin films exhibited prominent enhancement of their third-order NLO responses in two or three orders of magnitude compared to those obtained for their corresponding solutions. This work not only provides a new methodology to build irregular polyhedral structures in a controlled and tunable way but also provides access to new kinds of promising functional optical materials.
Therapeutic and Diagnostic Tactics for Adhesive Small Bowel Obstruction: Literature Review
Authors: Клюйко Д.А. , Корик В.Е.
Published: February 2022

Несмотря на прилагаемые усилия исследователей всего мира, количество пациентов со спаечным синдромом возрастает, остаются существенные трудности в лечении и профилактике данного заболевания. Распознавание спаечного синдрома у пациентов не является сложным диагностическим мероприятием, однако вопросы тактики ведения таких пациентов, перехода от консервативного лечения к оперативному остаются дискутабельными. Острая спаечная кишечная непроходимость является тяжелым заболеванием, в подавляющем большинстве случаев имеет странгуляционный компонент и требует агрессивной хирургической тактики. Консервативное лечение должно приводить к видимым положительным изменениям состояния пациента. При отсутствии значимой положительной динамики она должна расцениваться как отрицательная с немедленным переходом к оперативным методам лечения.

Despite the numerous efforts of researchers around the world, the number of patients with adhesive syndrome will increase; and significant difficulties remain in the treatment and prevention of this disease. Recognition of adhesive syndrome in patients is not a difficult diagnostic measure. However, the issues of tactics of managing such patients, transition from conservative treatment to surgical treatment remain controversial. Acute adhesive intestinal obstruction is a serious disease. In the overwhelming majority of cases, it has a strangulation component and requires more aggressive surgical tactics. The use of conservative therapy should lead to visible positive changes in the patient’s condition. In the absence of significant positive dynamics, it should be regarded as negative with immediate transition to operational methods of treatment.
Clinical Results of Treating Patients with Chronic Dystrophy of Ocular Surface Diseases on the Background of Corneal Syndrome
Authors: Семак Г.Р. , Майсак Ю.А. , Рындова Д.В.
Published: February 2022

Цель исследования. Установить эффективность, переносимость, безопасность комплексного лечения пациентов с роговичным синдромом с использованием инъекционной формы 1% низкомолекулярного натрия гиалуроната и комбинированных капель с содержанием нейропротектора и антиоксиданта кроцина, гиалуроновой кислоты (ГК) и липосом (Lumixa, Омисан, Италия).Материалы и методы. Все пациенты, включенные в исследование, длительно использовали слезозаменители без должного эффекта. Препарат Lumixa назначался в виде инстилляций 3–5 раз в день на протяжении 3 месяцев, при необходимости курс продлевался до 6 месяцев. При тяжелом течении дополнительно вводилась инъекционная форма 1%-ного низкомолекулярного натрия гиалуроната.Результаты и обсуждение. Применение капель с ГК, кроцином и липосомами положительно влияло на пробу Ширмера, время разрыва слезной пленки, тест Lipcof, увеличение чувствительности роговицы, уменьшение индекса OSDI. Клинически уменьшились чувство рези, светобоязнь, слезотечение.Заключение. Показана эффективность, хорошая переносимость и безопасность комбинированных капель Lumixa в лечении пациентов с дистрофическими заболеваниями роговицы, сопровождающимися роговичным синдромом. При тяжелой болезни сухого глаза после курса с введением инъекционной формы 1%-ного низкомолекулярного натрия гиалуроната пациенты продолжали длительно применять капли с нейропротекцией.

Purpose. To establish the efficacy, tolerability, safety of complex treatment of patients with corneal syndrome using an injectable form of 1% low molecular weight sodium hyaluronate and combineddrops containing the neuroprotector and antioxidant crocin, hyaluronic acid (HA) and liposomes (Lumixa, Omisan, Italy).Materials and methods. All patients included in the study used artificial ter drops for a long time without effect. Lumixa was prescribed in the form of instillations 3-5 times a day for 3 months, if necessary, the course was extended up to 6 months. In severe cases, an injectable form of 1% low molecular weight sodium hyaluronate was additionally administered.Results and discussion. The application of drops with HA, crocin and liposomes had a positive effect on Schirmer’s test, tear film rupture time, Lipcof test. An increase in corneal sensitivity, and a decrease in the OSDI index were registered. Foreign body sensation, photophobia, lacrimation also decreased.Conclusion. The efficacy, good tolerability and safety of combined Lumixa drops in the treatment of patients with cornea degenerative diseases accompanied by corneal syndrome have been shown. In severe dry eye disease after a course with the introduction of an injectable form of 1% low molecular weight sodium hyaluronate, patients continued to use drops with neuroprotection for a long time.
Features of the Emotional-Cognitive Sphere of Patients with Somatoform Disorders on the Example of Chronic Pain Dysfunction
Authors: Коцюбинская Ю.В. , Сафонова Н.Ю. , Михайлов В.А.
Published: February 2022

В данной работе на примере пациентов с хроническими болевыми дисфункциями исследовались особенности эмоционально-когнитивной сферы лиц с соматоформными расстройствами. В процессе исследования были выявлены статистически значимые различия между группой пациентов и контрольной выборкой как в отношении когнитивных функций, так и в эмоциональной сфере. Было обнаружено значимое снижение показателей рабочей памяти, концентрации внимания, а также общего тонуса у пациентов с соматоформными расстройствами, что, в общем, характерно для аффективных расстройств депрессивного круга. Обнаружилось, что для пациентов с соматоформными расстройствами негативное влияние аффективной интерференции на процессы запоминания выражено значительно сильнее, чем у здоровых испытуемых, тогда как статистически значимых различий по продуктивности механического запоминания не обнаружилось. Это указывает на особую роль эмоциональных нарушений в возникновении когнитивных расстройств у пациентов с соматоформными заболеваниями.

In this article, we studied the characteristics of the emotional-cognitive sphere of patients with somatoform disorders, using the example of patients with chronic pain dysfunctions. The study revealed statistically significant differences between the patient group and the control group in cognitive functions and emotional sphere. A significant decrease of memory, attention, and vitality was found in patients with somatoform disorders, which is typical for affective disorders of the depressive circle. It was found that for patients with somatoform disorders, the negative effect of affective interference on the processes of memorization is much more pronounced than in healthy subjects, while there were no statistically significant differences in the productivity of mechanical memorization. This data indicate the special role of emotional disorders in the occurrence of cognitive disorders in patients with somatoform diseases.
Cardiac Risk Stratification in Patients with Concomitant Atherosclerotic Lesions of the Carotid and Lower Limb Arteries
Authors: Янушко В.А. , Климчук И.П. , Кордзахия Г.Э.
Published: February 2022

Введение. Основные причины смертности пациентов с заболеванием периферических артерий связаны в первую очередь с инфарктом миокарда (60%), за которым следует инсульт (35%), часть этих пациентов (15%) умирает из-за прогрессирования ишемии нижних конечностей (гангрена, сепсис и полиорганная недостаточность).Цель. Обосновать необходимость выполнения коронароангиографии у пациентов с сочетанным поражением сонных и магистральных артерий нижних конечностей.Материалы и методы. В 2015–2019 гг. в отделении сосудистой хирургии УЗ «4-я ГКБ им. Н.Е. Савченко» и 1-м кардиохирургическом отделении ГУО «РНПЦ «Кардиология» были пролечены 180 пациентов с сочетанным атеросклеротическим поражением сонных артерий и артерий нижних конечностей. Из данной категории пациентов в целях диагностики выполнено 48 коронароангиографий.Результаты. Гемодинамически значимые поражения коронарных артерий обнаружены у 35 пациентов.Заключение. Всем пациентам с сочетанным поражением сонных и магистральных артерий перед планируемым оперативным вмешательствам необходимо выполнить коронароангиографию.

Introduction. The main causes of death in patients with peripheral arterial disease are primarily associated with myocardial infarction (60%) followed by stroke (35%); and some of these patients (15%) die due to progression of the lower limb ischemia (gangrene, sepsis and multiple organ failure).Purpose. To substantiate the need for coronary angiography in patients with combined lesions of the carotid and main arteries of the lower extremities.Materials and methods. In 2015–2019, at the department of vascular surgery of the 4th City Clinical Hospital named after N.E. Savchenko, Minsk and the first cardiac surgery department of the State Scientific and Practical Center “Cardiology”, 180 patients with concomitant atherosclerotic lesions of the carotid arteries and the lower limb arteries were treated. In this category of patients, 48 coronary angiographies were performed for diagnostic purposes.Results. Hemodynamically significant lesions of the coronary arteries were found in 35 patients. Conclusion. All patients with concomitant lesions of the carotid and main arteries should undergo coronary angiography before the planned surgical intervention.
Experience of the European Week for Early Diagnostics of Head and Neck Cancer in the Republic of Belarus
Authors: Тризна Н.М. , Колядич Ж.В.
Published: February 2022

В статье приводится шестилетний опыт участия специалистов РНПЦ ОМР им. Н.Н. Александрова в проведении Европейской недели ранней диагностики опухолей головы и шеи. Результаты бесплатных профилактических осмотров мультидисциплинарной бригадой врачей показали, что подобные мероприятия не ставят целью выявить как можно больше онкологических заболеваний данной локализации (доля пациентов со злокачественными новообразованиями составляет 3–4% от числа обратившихся к специалистам), но призваны привлечь внимание к этой проблеме и повысить осведомленность о раке головы и шеи населения и медицинских работников. Обязательным мероприятием Европейской недели ранней диагностики рака головы и шеи стало проведение республиканских научно-практических конференций и семинаров для обсуждения проблем ранней диагностики опухолей головы и шеи, взаимодействия специалистов, принимающих участие в диагностическом поиске и лечении опухолей головы и шеи.

The article provides a six-year experience of participation of the specialists from the N.N. Aleksan- drov National Cancer Center of Belarus in the Awareness Week for early diagnostics of head and neck cancer. The results of free preventive examinations by a multidisciplinary team of doctors showed that such events do not aim to identify as many oncological diseases of the given localization as possible (the proportion of patients with malignant neoplasms is 3–4% of the number of those, who applied to specialists), but they are designed to draw attention to this problem and increase head and neck cancer awareness among the general public and healthcare professionals. An obligatory event of the European week for early diagnostics of head and neck cancer was the republican sci- entific and practical conferences and seminars to discuss the problems of early diagnostics of head and neck tumors and interaction of specialists involved in the diagnostic search and treatment of head and neck tumors.
UJI KETAHANAN EMPAT VARIETAS TANAMAN JAGUNG TERHADAP WERENG Stenocranus pacificus Kirkaldy (Hemiptera: Delphacidae) DENGAN MENGGUNAKAN PERANGKAP WARNA BERPEREKAT DI KECAMATAN KUTALIMBARU KABUPATEN DELI SERDANG
Authors: Murdianti Putri
Published: February 2022

Observation of maize varieties resistance is the beginning to determine the level of resistance of each maize variety against of corn planthopper S. pacificus attacks and also to determine the most effective color trap used. This research  was carried out in a corn farm in Suka Rende Village, Kutalimbaru District, Deli Serdang Regency (500 meters above sea level) from July to November 2018. The research used a Separate Plot Design with the main plot being varieties (Bioseed 54, Bisi 18, Pioneer 32 , and Local) and subplots are color traps (white, yellow, blue, green). The results showed that the Bioseed 54 variety had a low level of resistance to corn planthopper S. pacificus attacks. The yellow color is the color preferred by S. pacificus planthoppers.
Analysis of the Effect of Profitability Ratio on Stock in Cigarette Companies in Indonesia Stock Exchange
Authors: Lubis Afriani
Published: February 2022

This research to determine and analyze the influence of Net Profit Margin, Return On Asset, and Earning Per Share of Stock Price in ciagarette companies in Indonesian Stock Exchange. This research period starting from 2007 until 2011. The hypothesis put forward is the Net Profit Margin, Return On Asset, and Earning Per Share simultaneously and partially influenced the Stock Price in ciagarette companies in the Indonesian Stock Exchange. This research is a causal associative type of research, namely to measures causal relationships between two or more variables through hypothesis testing. The population in this study is the company's ciagarette in Indonesia Stock Exchange a total of 3 companies. This research used saturated sampling and obtained a sample of 3 companies. The data used are secondary data Methods of data analysis using descriptive analysis method and multiple linear regression analysis.

F test results showed that the independent variables Net Profit Margin, Return On Asset, and Earning Per Share simultaneously influential and significant effect on Stock Price. Partial test results (Test-t) show that the Net Profit Margin, Return On Asset and Earning Per Share has a significant influence the Stock Price in ciagarette companies in Indonesian Stock Exchange.
Implementación del Growth Hacking en las pequeñas y medianas empresas. Caso: Ambato – Ecuador
Authors: Chavarría-Zambrano Katherine Lisbeth , Medina-Chicaiza Ricardo Patricio
Published: February 2022

Las Mipymes (micro, pequeñas y medianas empresas) son sector prioritario en el Ecuador, por tanto, su escalamiento demanda del comercio electrónico. En este contexto, es menester la implementación de estrategias innovadoras del marketing digital. Considerando esto se presenta una propuesta para las Mipymes Ambateñas basadas en el Growth Hacking. Metodológicamente, la propuesta deviene de una revisión teórica documental. La observación sistemática implicó asumir una lógica de acción estructurada mediante los procesos de: rastreo, identificación, organización, sistematización, análisis e interpretación, de datos recabados de las producciones académicas-científicas. Finalmente, con el acceso a la tecnología, que tienen tanto empresas como ciudadanos comunes, el Growth Hacking representa una disciplina que apunta a estrategias de vanguardia, novedosas y enfocadas en el fenómeno de la viralización, pues, se constituye en posibilidad para llegar más rápido y masivamente a los usuarios, convertirlos en clientes y generar el crecimiento acelerado de las empresas y los negocios.
Phytoextraction of mercury (Hg) in soils contaminated by button batteries using Bamboo “Bamnusoideae”
Authors: Secundino-López Mitzi Gabriela , Galicia-Luis Laura , Lozano-Camargo Maria Luisa
Published: February 2022

The pollution of the planet has generated a series of problems for the environment and human health, such as the case of soils contaminated by heavy metals from batteries that are improperly disposed of in domestic garbage and sanitary landfills; Button batteries (HgO) pollute the soil, since mercury is very persistent in the environment due to its biomagnification and its great capacity to accumulate in organisms causing diseases in humans at the skin level, respiratory tract, digestive system, etc. . this being a highly toxic metal worldwide. The accumulation of Hg in soils depends on physicochemical factors such as pH, redox potential, organic matter, and clay. The main objective of this research work is to implement mercury phytoextraction in soils contaminated by button cells, using “Bamnusoideae” Bamboo, a UV-Vis spectroscopic study was carried out to determine the desorption of Hg from the contaminated soil, images of the stem were obtained, leaves and roots of bamboo without contamination and contaminated with Hg with a VE-B6 microscope, rating: 85V to 265V 50/60 Hz, Halogen Lamp: 12V 30W, and the pH of the contaminated soil was measured.
Video as a didactic resource in a hybrid learning environment
Authors: Hernández-Báez Irma Yazmín , Nieto-Yáñez Alma Delia , López-Díaz Roberto Enrique , León-Sosa Sandra Elizabeth
Published: February 2022

The teaching-learning process had a drastic change with the pandemic, first it changed from face-to-face to virtual and later it changed to a hybrid modality. In the case of the Universidad Politécnica del Estado de Morelos, the hybrid modality consists of synchronous sessions with students in the classroom and online, this increases the complexity of the design of the appropriate learning environment. The objective of this research was to obtain information that would allow us to see if the use of video as an educational resource has a positive impact on the teaching-learning process in current days. To verify this, the methodology used consisted of five stages: Selection of technological tools, design of the action process using video for each of the four spaces of a hybrid learning environment, execution of the action process, answering surveys and analysis of results. With this study, it was possible to provide teachers with a strategy that allows them to expand their personal toolbox during the teaching-learning process in hybrid environments.
Use of anatomical models in the teaching of veterinary anatomy as an animal welfare strategy
Authors: Alcázar-Chávez Itzcoatl , Olmedo-Pérez Gerardo , Estrada-Dávila María Graciela , Tabarez-Rojas Abigail
Published: February 2022

Anatomy is the science that studies the macroscopic composition of animal body and is a fundamental pilar within the discipline of veterinary medicine, for its study over the years animals and their corpes have been used, but today several changes: social, cultural and environmental, as well as the human- animal connection, are forcing institution to implement bioethical alternatives to the use of these. The purpose of this compilation is to provide an up-to date overview of the use of anatomical models in the teaching of veterinary anatomy as an animal welfare strategy, based on the 3R´s principles proposed by the OIE, in order to make know the different alternatives that currently exist to the use of cadavers and vivisection, as well as the advances in technological innovation in the teaching of veterinary anatomy and its applications within the specialty
Production indicator models for fodder maize (Zea mays L.) in the Comarca Lagunera II
Authors: Montemayor-Trejo José Alfredo , López-Antonio Roberto , Sifuentes-Morín Norma Guadalupe , Servín-Prieto Alan Joel
Published: February 2022

Forage corn is a crop in greatest demand in the Comarca Lagunera. The objective is to obtain the models for the production indicators of forage maize hybrids, which could improve the production systems. The variables evaluated were: leaf area index (IAF), number of leaves and dry matter (DM). The DM model as a function of the IAF was 17.13 grams plant per unit of IAF. For the days after sowing (DDS) a production of 5 grams plant / elapsed day was found. For IAF based on DDS, 0.36 units of IAF were obtained per day and the IAF increased by 0.65 units as a function of the number of leaves. It is concluded that the behavior of the evaluated variables provides results of linear and polynomial regression models, with different levels of reliability, which allow future estimates to be made to choose the hybrids that best adapt to the region.
INTERCORRÊNCIAS OBSTÉTRICAS QUE OCASIONAM O PRÉ-NATAL DE ALTO RISCO
Authors: Eduarda Otoni Da Silva Garrido Maria , Caroline de Souza Anne , Soares Rufino Roneiza , de Oliveira Teógenes , Barros de Quental Ocilma , de Lira Silva Macerlane
Published: February 2022

RESUMO: a assistência ao pré-natal é a melhor forma da prevenção de complicações durante o período gestacional e o parto, sendo assim, para um melhor resultado, as consultas devem ser realizadas por uma equipe multiprofissional capacitada, capaz de reconhecer as necessidades das gestantes durante toda a gravidez até o período puerperal. Este estudo foi realizado em 2021, e trata-se de uma revisão integrativa da literatura, que foi desenvolvida nas bases de dados Scientific Electronic Library Online (SCIELO), Biblioteca Virtual de Saúde (BVS) e sites do Ministério da Saúde, utilizando os descritores: “Gravidez”, “Assistência pré-natal”, “Gestação de alto risco”, “Complicações na gravidez”. Pesquisaram-se documentos dos últimos cinco anos, na íntegra, gratuitos e que respondessem a questão norteadora inicial. No ano de 2000, a mortalidade materna era um dos principais problemas mundiais, e, após implementação de programas e políticas de saúde às gestantes e puérperas, houve uma significativa melhoria na assistência materno-infantil, resultando na diminuição da mortalidade, porém, os números de intercorrências ainda são considerados altos. As principais causas de intercorrências são os fatores adquiridos durante a gestação, que evolui como risco gestacional, como, por exemplo, hemorragias, pré-eclâmpsia ou eclampsia, diabetes gestacional, quantidade de fetos e de líquido amniótico, contração de doenças infectocontagiosas, exposição a agentes teratogênicos ou óbito. Sendo assim, é importante investigar lacunas na atenção primária do pré-natal, fortalecer a atenção especializada e manter as políticas públicas, com vistas a otimizar os indicadores de saúde materna e infantil.

Descritores: Gravidez. Assistência pré-natal. Gestação de alto risco. Complicações na gravidez.
Refusing Refusal: The Struggles of Stateless Palestinians in the Swedish Migration Regime
Authors: Lindholm Helena
Published: February 2022

This article explores the ways in which contemporary Swedish migration politics are manifested and performed in relation to stateless Palestinians. A qualitative case study shows how the migration regime of Sweden aggravates conditions of statelessness through managerial aspects of categorisations, temporalities, passivisation and spatialities. The article illustrates how securitised migration politics are detrimental to how statelessness is lived and experienced but also that stateless migrants actively engage with this regime in order to resist, protest and achieve change. Using counter-conduct as a prism through which to analyse migrant resistance, the article further explores how stateless migrants do not passively submit themselves to the outcome of penalising regimes, but struggle for a right of presence.
Sea Level Rise and Climate Statelessness: From 'Too Little, Too Late' to Context-Based Relevance
Authors: Rouleau-Dick Michel
Published: February 2022

Several low-lying island states currently risk the loss of their entire territory before the end of the century. Combined with the inadequacy of the existing framework of international refugee law to address the challenges faced by those displaced, this situation has made the law on statelessness an interesting candidate for securing an alternative path to obtaining a legal status in a post-relocation context. However, while several authors have examined this possibility, the majority conclude that it fails in its putative task by providing too little, and by coming into play too late to be of any significant relevance to the situation of environmentally displaced persons in low-lying island states. This article challenges this narrative by re-examining the relevance of the law on statelessness along with the context within which it might have to play a role.
Tanah Tumpahnya Darahku: The ‘Genuine and Effective Link’ in Establishing Malaysian Citizenship
Authors: Kian Leong Tan
Published: February 2022

Article 14(1)(b) of the Federal Constitution of Malaysia, when read together with sch II pt II s 1(e), theoretically acts as a safety net for Malaysian-born persons by conferring citizenship upon those who would otherwise be stateless. In practice, however, these provisions have been interpreted as imposing a dual jus soli/jus sanguinis requirement that must be satisfied before citizenship can be granted. Consequently, many persons prima facie entitled to Malaysian citizenship by operation of law are deprived of their entitlement. This article explores the possibility of adopting the Nottebohm (Liechtenstein v Guatemala) ‘genuine and effective link’ principle as a supplementary element of the s 1(e) citizenship test. Support for adoption is derived from the Parliament of Malaysia’s intent throughout the history of amendments to the citizenship provisions in the Constitution. The article further considers the plausibility of a direct legal transplantation of the principle into Malaysian law, drawing upon various sources including international law and English common law.
'I Must Be from Somewhere. I'm Not from the Moon': Navigating the Politics of Labelling for Stateless Palestinian Refugees from Syria
Authors: Tucker Jason , Bahram Haqqi
Published: February 2022

This article explores the relationship between statelessness and refugeeness over time and space. It does so by drawing on how Palestinian refugees from Syria in Sweden navigate the various stateless and refugee labels imposed upon them before, during and after their flight from Syria to Sweden. Standpoint theory was deployed as the basis for understanding how this group of stateless refugees related to these labels. While the research found that, even though the labelling process was largely non-participatory, both as a manifestation for epistemic agency and a vehicle for epistemic justice in statelessness and refugee research, standpoint theory has offered an indispensable lens through which we have accessed the multiple strategies that the interviewees adopted to accept, reject, resist or negotiate their re/de-labelling throughout their journey.
Legal Identity and Minority Statelessness in Cambodia: Recent Developments
Authors: Sperfeldt Christoph
Published: February 2022

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Legal Identity, Race and Belonging in the Dominican Republic: From Citizen to Foreigner by Eve Hayes De Kalaf (Anthem Press 2022) 126 Pages. Price $40.00. ISBN 9781785277641
Authors: Petrozziello Allison
Published: February 2022

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ECOLOGICAL AND GEOGRAPHICAL POTENTIAL OF AMBROSIA ARTEMISIIFOLIA L. DISTRIBUTION TO THE NORTH OF THE EUROPEAN RUSSIA BASED ON A COMPARISON OF THE NORTHERN BOUNDARIES OF THE PRIMARY AND SECONDARY RANGES
Authors: Afonin A. N. , Baranova O. G. , Fedorova Y. A. , Abramova L. M. , Boshko T. F. , Kotsareva N. V. , Li Yu. S. , Milyutina E. A. , Pikalova N. A. , Prokhorov V. E. , Senator S. A.
Published: February 2022

During the expeditionary research, we specified the modern actual border of naturalization of in the European territory of Russia. This border passes through Kursk Region, as well as the north of Voronezh and Saratov regions. The total length of the expeditionary routes was around 8900 km with 777 locations surveyed. In order to identify the potential for its further spread to the north we performed comparative ecological and geographical analysis and modeling of the ragweed distribution in the north of its secondary range in the European Russia and in the primary range in Canada. Insufficient heat supply during the seed ripening period is the main factor limiting the spread of ragweed to the north. To determine the ecological and geographic niche of ragweed, we compiled a global map of the distribution of accumulated degree days above 10 °C for the period from the transition of the day length under 14 hours to the stable frosts in autumn (ADDfp). The ADDfp values were determined at the northernmost points of naturalization of in the European Russia and in Canada. Comparison of the ecological and geographical boundaries regarding the heat supply in the European Russia and in Canada showed that the ecological and geographical niche realized by ragweed in the North America is now generally wider than the one on the European Russia. We considered the possible reasons for the under-occupation of a potential ecological niche in the European Russia and made assumptions about the possibility of its further spread to the north. Regarding the factor of heat supply in the European Russia, ragweed can spread further to the north - in Bryansk, Oryol, Lipetsk, Tambov, Saratov, Orenburg regions, southern half of Penza Region, the south of Ulyanovsk and Samara regions and Bashkortostan. Additional difficulties with the species’ distribution in the northeastern direction in the European Russia can be attributed to an adverse effect of an additional factor: insufficient moisture supply, since in the Saratov Region and to the east ragweed is in the ecological pessimum simultaneously in terms of heat and moisture supply at its northern limit of distribution.
Investigation of Various Parameters in Magneto-Rheological Dampers
Authors:   Professor, Amity University, Sector 125, Noida – 201313, India, Tyagi R.K , Joshi Preeti ,   Assistant Professor, Amity University, Sector 125, Noida – 201313, India., Pandey R.S ,   Professor, Amity University, Sector 125, Noida – 201313, India
Published: February 2022

Automobile industry and magneto-rheological dampers are now a new area of research. Magneto-rheological mufflers utilize the energy generated by magnetic fields, and scientists have initiated a re-consideration of new damping systems. The suspension system based on magneto-rheological fluid in modern era is becoming an intelligent system with superior properties such as strength, controllability, range, response time, energy utilization, structure etc. In magneto-rheological dampers number of required components are too less which leads to cost effective suspension. In this exploration, a magneto-rheological damper was fabricated, and experimental study had been performed. The magneto-rheological damper's construction cost is not as much since it doesn’t have intricate components. The modern enquiries the consequences of magnetic field/current on applied load, yield stress, and stress developed in suggested magneto-rheological dampers. The experimental results illustrate the effect of external load, yield stress, & stress generated in suggested dampers depends on magnitude of current/magnetic field. The experimental investigation also demonstrates that magneto-rheological dampers work at a specific threshold magnetic field substandard to critical value of a magnetic field, magneto-rheological fluid reposes in a liquid phase. The threshold magnetic field and mechanical properties are inter-related with each other in magneto-rheological based dampers.
Awareness of Employees Towards Performance Appraisal Mechanism in Salem Steel Authority of India Limited: A Micro Level Study
Authors:   Ph.D Research Scholar, PG and Research Department of Commerce, Laxminarayana Arts and Science College for Women, Dharmapuri (Tamil Nadu), India., Hemalatha P. , Kumaresan D. ,   Research Supervisor and Former Principal, PG and research Department of Commerce, Laxminarayana Arts and Science College for Women, Dharmapuri (Tamil Nadu), India.
Published: February 2022

The performance appraisal is feedback given to the employees about their past and current performances. The paper mainly focuses on Awareness of Employees towards Performance appraisal mechanism in Salem Steel Authority of India Limited. The primary data have been collected from the selected employees of SAIL, Salem using a structured questionnaire. The population size finite and known accordingly the sample size has been determined to be 445 and systematic random sampling method is used. The demographic variables such as gender, age, marital status and educational level were compared with the awareness of employees towards the selected purposes of performance appraisal has been analyzed. It is understood from the analysis that the awareness of employees was affected by the age and nature of job