bluuebunny/crossref_metadata_2025 huggingface dataset:
Why is Iron Deficiency Recognised as an Important Comorbidity in Heart Failure?
Authors: Ebner Nicole , von Haehling Stephan
Published: September 2019

There is an increasing awareness of the prevalence of iron deficiency in patients with heart failure (HF), and its contributory role in the morbidity and mortality of HF. Iron is a trace element necessary for cells due to its capacity to transport oxygen and electrons. The prevalence of iron deficiency increases with the severity of HF. For a long time the influence of iron deficiency was underestimated, especially in terms of worsening of cardiovascular diseases and developing anaemia. In recent years, studies with intravenous iron agents in patients with iron deficiency and HF showed new insights into the improvement of iron therapy. Additionally, experimental studies supporting the understanding of iron metabolism and the resulting pathophysiological pathways of iron have been carried out. The aim of this mini review is to highlight why iron deficiency is recognised as an important comorbidity in HF.
Featuring: Josep Brugada
Authors: Brugada Josep
Published: September 2019

In the Cardiology Masters section of European Cardiology Review, we bring you an insight into the career of a key contributor to the field of cardiology. In this edition, we feature Josep Brugada.
The Local Earthquake Tomography of Erzurum (Turkey) Geothermal Area
Authors: Ozer Caglar , Ozyazicioglu Mehmet
Published: October 2019

Erzurum and its surroundings are one of the seismically active and hydrothermal areas in the Eastern part of Turkey. This study is the first approach to characterize the crust by seismic features by using the local earthquake tomography method. The earthquake source location and the three dimensional seismic velocity structures are solved simultaneously by an iterative tomographic algorithm, LOTOS-12. Data from a combined permanent network comprising comprises of 59 seismometers which was installed by Ataturk University-Earthquake Research Center and Earthquake Department of the Disaster and Emergency Management Authority  to monitor the seismic activity in the Eastern Anatolia, In this paper, three-dimensional Vp and Vp/Vs characteristics of Erzurum geothermal area were investigated down to 30 km by using 1685 well-located earthquakes with 29.894 arrival times, consisting of 17.298 P- wave and 12.596 S- wave arrivals. We develop new high-resolution depth-cross sections through Erzurum and its surroundings to provide the subsurface geological structure of seismogenic layers and geothermal areas. We applied various size horizontal and vertical checkerboard resolution tests to determine the quality of our inversion process. The basin models are traceable down to 3 km depth, in terms of P-wave velocity models. The higher P-wave velocity areas in surface layers are related to the metamorphic and magmatic compact materials. We report that the low Vp and high Vp/Vs values are observed in Yedisu, Kaynarpinar, Askale, Cimenozu, Kaplica, Ovacik, Yigitler, E part of Icmeler, Koprukoy, Uzunahmet, Budakli, Soylemez, Koprukoy, Gunduzu, Karayazi, Icmesu, E part of Horasan and Kaynak regions indicated geothermal reservoir.
Characteristics and dolomitization of the Lower Qiulitage Group reservoir in Bachu Uplift, Tarim Basin, China
Authors: Li Bin , Xia Qingsong , Peng Jun , Yang Suju , Xu Qingqi , Zeng Lei
Published: October 2019

The characteristics of the Lower Qiulitage Group in Bachu uplift, which originated in the Upper Cambrian period, are not clear. Based on four core observations, identification of 40 thin sections, and geochemical analysis of samples, this study concludes that crystal dolomite reservoirs developed in the Lower Qiulitage Group in Bachu uplift. Intercrystalline pores and dissolved pores formed the main reservoir space, while dissolution pores and fractures were developed in the middle and bottom part of the formation. The reservoir features low porosity and low permeability, and the fine-medium crystalline dolomite reservoir has the best pore structure. According to a petrochemical analysis, the Lower Qiulitage Group reservoir experienced intense dolomitization, with slightly higher content of trace elements Mn and Sr and negative oxygen isotropy. Tectonic hydrothermal dolomitization developed locally under the influence of base faults, and vug pores were filled with saddle dolomites and siliceous filling. The presence of rare earth elements Ce and Eu presented positive anomaly characteristics. It suggested that the CO2 acid dissolution caused by hydrothermal fluids may be a new mechanism for the increase in pores in deeply buried reservoirs, which is worth further study.
Moenkhausia hemigrammoides Géry, 1965 (Characidae, Stethaprioninae) in Colombia: new records and comments on morphology
Authors: Méndez-López Alejandro , Urbano-Bonilla Alexander
Published: October 2019

Moenkhausia hemigrammoides Géry, 1965 was described from Suriname and recently found in the Ariari drainage, part of the Orinoco river basin. Here, we formally report the presence of this species in the Ariari and Inírida drainages of the Guaviare River and present morphological data that complement the original description. Our records of M. hemigrammoides represent the westernmost distribution for this Guianan species in the Amazonas–Orinoco transition zone.
Sand burrowing mayflies of the family Behningiidae (Ephemeroptera) from South Korea
Authors: Park Hyoung Rye , Lee Sang Wook , Cho Geonho
Published: October 2019

New distributional record of little-known Behningiidae is presented from South Korea for Behningia tshernovae Edmunds & Traver, 1959. South Korea represents the first report of the species outside of the Russian Far East. We provide the photos of B. tshernovae nymphs as well as the male and female for diagnosis and confirm the previously known relation between the larva and adult.
O MODELO SERVICESCAPE APLICADO EM HOSPITAIS PÚBLICOS: uma análise da influência do ambiente físico na experiência de serviço do cidadão
Authors: Santos Aline Regina , Silva Barbara Cavalheiro da
Published: October 2019

Servicescape é o termo que designa o ambiente físico onde ocorre o serviço. Nos serviços prestados em local específico, como os hospitais, o cenário assume importante papel, pois influencia a percepção de qualidade do serviço. Dado o contexto, a presente pesquisa tem por objetivo analisar a influência do ambiente de emergências de hospitais públicos na experiência vivenciada pelo cidadão. Para tanto, empreendeu-se pesquisa qualitativa, mediante observação do ambiente de espera de dois dos maiores hospitais públicos da Grande Florianópolis. Além, foram realizadas entrevistas em profundidade com dois pacientes e quatro acompanhantes, que estiveram em pelo menos um dos hospitais analisados, nos últimos anos. Os dados coletados foram analisados à luz do modelo Servicescape de Bitner (1992). Entre os resultados, observou-se a presença de elementos teóricos na fala dos entrevistados, bem como de outros não contemplados na teoria. Pontua-se também que o cenário é capaz de atenuar impressões negativas do atendimento.
Comparison of Objects’ Images based on Computational Topology Methods
Authors: Chukanov Sergey
Published: October 2019

The paper considers methods for comparison of objects’ images represented by sets of points using computational topology methods. The algorithms for construction of sets of real barcodes for comparison of objects’ images are proposed. The determination of barcodes of object forms allows us to study continuous and discrete structures, making it useful in computational topology. A distinctive feature of the use of the proposed comparison methods versus the methods of algebraic topology is obtaining more information about objects’ form. An important area of application of real-valued barcodes is studying invariants of big data. Proposed method combines the technology of barcodes construction with embedded non-geometrical information (color, time of formation, pen pressure), represented as functions of simplicial complexes. To do this, barcodes are expanded with functions from simplexes to represent heterogeneous information. The proposed structure of extended barcodes increases the effectiveness of persistent homology methods when comparing images and pattern recognition. A modification of the Wasserstein method is proposed for finding the distance between images by introducing non-geometric information about the distances between images, due to inequalities of the functions of the source and terminal images of the corresponding simplexes. The geometric characteristics of an object can change with diffeomorphic deformations; the proposed algorithms for the formation of expanded image barcodes are invariant to rotation and translation transformations. We considered a method for determining the distance between sets of points representing the curves, taking into account an orientation of curves’ segments. The article is intended for a reader who is familiar with basic concepts of algebraic and computational topology, the theory of Lie groups, and diffeomorphic transformations.
Diagnostic assessment of endothelial function in metabolic syndrome and coronary heart disease
Authors: Nevzorova V. A. , Nastradin O. V. , Pomogalova O. G. , Potapova E. S.
Published: October 2019

Aim. To study the endothelial status, endothelial relaxation and constriction reserve, inflammation markers, and adipokines in men with metabolic syndrome (MS) and various forms of coronary heart disease (CHD). Material and methods. In total, 236 male patients (mean age 56,5±2,07 years) were followed up. Serum levels of NO metabolites (NOnˉ), endothelin-1 (ET-1), and C-reactive protein (CRP) were measured, as well as the levels of cytokine system components (interleukin (IL) 6 and 10), tumor necrosis factor (TNF) alpha, and adipokines (leptin and adiponectin). Results. Endothelial dysfunction was manifested in reduced levels of NO metabolites in MS and additional increase of serum ET-1 concentration in CHD. Serum CRP levels were increased in MS and CHD, being maximal in patients with Q-wave myocardial infarction (MI). In MI patients, the levels of TNF-alpha and IL-10 were decreased, while IL-6 concentration was elevated. Leptin concentration was increased in participants with MS only, or the combination of MI and MS. Adiponectin levels were decreased in MI patients, regardless of MS presence or absence. Conclusion. The combination of MS and CHD was characterised by endothelial dysfunction. Serum inflammatory activity (increased CRP levels) was elevated in MS and was maximal in Q-wave MI. Serum levels of adipokines were dependent on MS presence or absence, with increased leptin concentration both at the risk factor stage and the Q-wave MI stage.
Imidazoline receptor agonist moxonidine and arterial hypertension treatment in women with menopausal metabolic syndrome
Authors: Tishina E. V. , Mychka V. B. , Zhernakova Yu. V. , Ivanov K. P. , Tolstov S. N. , Chazova I. E.
Published: October 2019

Aim. To assess the long-term effectiveness and safety of moxonidine (Physiotens®), as antihypertensive treatment in patients with metabolic syndrome (MS), including women with menopausal MS. Material and methods. The study included 274 patients: 203 women (74 %) and 70 men (26 %). Postmenopausal women comprised a separate study subgroup. At baseline and after 24 weeks of moxonidine treatment, all participants underwent anthropometry and the measurement of systolic and diastolic blood pressure (SBP, DBP), lipid and carbohydrate metabolism parameters. Results. Moxonidine therapy was associated with a reduction in SBP and DBP levels. A positive dynamics in the levels of fasting glucose, total cholesterol, low and high-density lipoproteins (LDL, HDL), and triglycerides was observed. The changes in these parameters were similar among postmenopausal women and all study participants. Conclusion. In MS patients, moxonidine improved circadian BP profile, and also demonstrated beneficial effects on carbohydrate and lipid metabolism parameters in women with menopausal MS.
The role of vasodilating β-blockers in controlling arterial hypertension as a means of reducing cardiovascular and stroke risk
Authors: Basile Jan N.
Published: October 2019

β-blockers have played a key role in the management of hypertension-related cardiovascular disease for decades, and continue to be recommended as a mainstay of therapy in national guidelines statements. Recent data have shown less optimal reductions in total mortality, CVD mortality, and CVD events with β-blockers compared with renin-angiotensin system-blocking agents or calcium channel blockers. The β-blocker class, however, spans a wide range of agents, and the growing concern about the risk-benefit profile of β-blockers should not be generalized to later-generation vasodilating β-blockers such as carvedilol and nebivolol. A growing database from hypertension studies confirms the clinical efficacy and safety of vasodilating β-blockers, and outcome studies indicate that these agents can play an important role in global CVD reduction in patients with hypertensive or ischemic heart failure.
Hemostasis protein-coding genes, peripheral hemostasis parameters, and atherothrombosis predisposition in patients with cardiovascular disease
Authors: Lifshits G. I. , Danilkina S. T. , Guskova E. V. , Voronina E. N. , Filipenko M. L.
Published: October 2019

Aim.To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD).Material and methods.The study included 76 patients. Polymorphic gene marker alleles were analyzed by PCRPDRF method.Results.The genotype prevalence was assessed for the polymorphic variants of F V, F II, Gp Iα, Gp IIIα, Gp Iβα, PAI-1, and FBG genes. In CVD patients, a polymorphic variant 4G (-675)5G of PAI-1 gene was associated with peripheral hemostasis disturbances.Conclusion.5G allele of PAI-1 gene was associated with higher plasminogen concentration and lower PAI-1 levels, which resulted in reduced plasma thrombogenicity.
Comparative effectiveness of hypertensive crise management in the post-surgery period after carotid endarterectomy: first results
Authors: Vertkin A. L. , Khamitov F. F. , Mayboroda E. L. , Litvin T. G. , Khovasova N. O.
Published: October 2019

Aim. To compare the effectiveness of different antihypertensive medications in the management of hypertensive crise (HC) in the early post-surgery period after carotid endarterectomy (CEE). Material and methods. The study included 39 patients (14 women, 25 men; mean age 65,6±6,6 years) hospitalised to the Cardiovascular Surgery Department of a major Moscow City hospital. All patients underwent CEE, with a HC developed in the early post-surgery period. All participants were divided into three groups: in Group I, HC was treated with nimodipine, while Groups II and III received enalaprilat and uradipil, respectively. Results. Intravenous administration of all three medications resulted in an antihypertensive effect. A significant reduction in blood pressure (BP) levels was observed after the administration of nimodipine and uradipil. However, nimodipine caused reflectory tachycardia, which was not observed in patients treated with uradipil. Conclusion. The results obtained are consistent that out of the three studied medications, uradipil appeared the most appropriate for the HC management in the early post-CEE period. It reduced BP levels without causing reflectory tachycardia or clinical hypotension, which confirms clinical effectiveness and safety of uradipil as a medication of choice for the urgent HC management.
New potential of Trimetazidine MB for coronary heart disease treatment in the real-world clinical practice: results of the Russian multi-centre randomised study PERSPECTIVE (Part II)
Authors: Bubnova M. G. , Aronov D. M. , Oganov R. G. , Rudomanov O. G.
Published: October 2019

Aim. As a clinical part of the Russian multi-centre randomised study, to assess the clinical benefits and safety of adding Trimetazidine MB to the standard treatment scheme in patients with stable angina (SA), in order to optimise their ambulatory therapy and improve their compliance. Material and methods. The study included 981 patients with Functional Class (FC) II-III SA and various concomitant diseases and syndromes, such as chronic heart failure (CHF), Type 2 diabetes mellitus (DM-2), or chronic obstructive pulmonary disease (COPD) in smokers. All participants were divided into two groups: Group I (n=838) received standard therapy plus trimetazidine MB (70 mg/d, twice a day), while Group II (n=143) received standard therapy only. The treatment and follow-up phases lasted for 12 months. Results. In Group I, the weekly number of angina attacks decreased by 42 % from the baseline at one month (р<0,0001), and by 70 % at 12 months (р<0,0001). The number of nitroglycerin (NTG) tablets taken decreased, respectively, by 41 % (р<0,0001) and 68 % (р<0,0001). In Group II, the decrease in angina attack number and NTG tablet number was significant only at 6 months and was less pronounced than in Group I. Therefore, in Group I, the number of patients with FC I increased by 7 times, while the number of FC III patients decreased by 1,8 times. No marked FC dynamics was observed in Group II. In Group I, left ventricular ejection fraction (LVEF) increased by 2,4 % (р<0,001), while interventricular septum and LV posterior wall thickness decreased, respectively, by 4,2 % (р<0,01) and 3,5 % (р<0,01). These parameters, however, did not change substantially in Group II patients. At 12 months, the number of patients hospitalised due to clinical decompensation, or becoming disable, was twice as high in Group II as in Group I. Conclusion. The Russian “PERSPECTIVE” Study results demonstrated high clinical effectiveness and safety ofTrimetazidineMB therapy, combined with standard treatment, in SA patients with CHF, DM-2, and COPD. Therefore, metabolic therapy could be more widely used in the real-world clinical settings.
Prevalence of cardiovascular risk factors and cardiovascular prevention quality in primary healthcare in Russia and European countries: EURIKA Study results
Authors: Boytsov S. A.
Published: October 2019

Background. In the Russian Federation (RF), the prevalence of cardiovascular disease (CVD) and CVD mortality levels are very high. Selected aspects of cardiovascular risk factor (RF) control and preventive activity of healthcare professionals have been investigated in numerous studies; however, relatively little research has been done in the area of primary CVD prevention. The EURIKA Study (NCT00882336) is a multicentre international cross-sectional study which involved 12 countries. In the RF, 604 patients were enrolled in the study at 26 clinical centres. Material and methods. The participating patients were recruited during routine clinical visits. The study population included primary care and ambulatory patients aged over 50 years, with at least one additional RF, but without previously registered CVD events or CVD hospitalisations. Results. In the Russian sample, the proportion of patients under 65 years was 81,5% (mean age 58,3±7,3 years). The proportion of women was 68,2%. Mean levels of body mass index and waist circumference were, respectively, 29,6±5,1 kg/m2 and 96±14,0 cm. More than a half of the patients (54,5%) reported low levels of physical activity. Weekly alcohol consumption was 1,8±3,9 drinks; 25,5% of the patients were current smokers, and 15,4% were ex-smokers. Mean levels of systolic and diastolic blood pressure (BP) were 136,5±17,5 and 84,3±11 mm Hg, respectively. The prevalence of arterial hypertension (AH) was 80,5%, left ventricular hypertrophy – 14,3%, and microalbuminuria – only 0,7%. Family history of premature CVD, dyslipidemia (DLP), or diabetes mellitus was reported by 37,9%, 50,5%, and 15,7%, respectively. Among AH patients, 85,4% received antihypertensive therapy, but only 35,9% achieved target BP levels. Only 49,8% of DLP patients received lipidlowering therapy, with target levels of total cholesterol and low-density lipoprotein cholesterol achieved in 24,3%. Conclusion. Currently, the main target group for cardiovascular prevention in the Russian Federation is represented by women of early retirement age, with AH and low or moderate SCORE risk levels, who actively seek medical help. However, the highest risk of CVD events is observed in working-age men over 40 years, who rarely seek medical help and, therefore, are not covered by cardiovascular prevention measures.
Heart rate reduction as a therapeutic goal: focus on primary prevention
Authors: Orlova Yu. A. , Makarova G. V. , Mikhailova G. V. , Ageev F. T.
Published: October 2019

Recently published studies have demonstrated a direct link between heart rate (HR) and prognosis across various populations and clinical groups, including elderly people, patients with arterial hypertension, myocardial infarction, and coronary artery stenting, overweight patients, or even young people with relatively low cardiovascular risk levels. HR is considered as an additional independent risk factor (RF) of cardiovascular disease (CVD). However, thus far, pharmaceutical HR reduction has been demonstrated to improve prognosis only in patients with coronary heart disease or chronic heart failure. The results in CVD-free patients have been contradictory. The review discusses the potential of different HR-reducing therapeutic regimens, as a part of primary CVD prevention.
Life event perception, psychological coping, and psychotherapeutic correction of blood pressure in patients with arterial hypertension
Authors: Bronskyi V. I. , Lapanov P. S.
Published: October 2019

Aim. To assess the associations between the perception of stressful life events, psychological coping (PC) styles, and the progression of arterial hypertension (AH); to identify psychotherapeutic approaches towards blood pressure (BP) correction, based on the perception self-control. Material and methods. In 3 groups of the patients with AH Stages 1—3, the diagnostics of stress resilience and social readjustment (Holmes and Rahe scale) and the Life Style Index assessment (Plutchik, Kellerman, and Conte scale) were performed. Results. The study results supported the view on AH progression as a process of decreasing adaptation and inadequate PC (5 PC styles out of 8 were inadequate). No statistically significant difference in PC parameters was observed across AH stages. Conclusion. The study findings have been used for identification of psychotherapeutic (psychoanalytic) approaches towards BP correction, based on the perception self-control.
Omega-3 index of erythrocytes and predictors of sudden cardiac death in patients with coronary heart disease and ventricular arrhythmias
Authors: Gavva E. M. , Tsaregorodtsev D. A. , Mamedov I. S. , Sulimov V. A.
Published: October 2019

Aim.To assess the association between ω-3 index of erythrocytes and demographic, electrophysiological, and echocardiographic (EchoCG) predictors of sudden cardiac death (SCD) in patients with coronary heart disease (CHD) and ventricular arrhythmias (VA).Material and methods.The study included 25 patients with a verified diagnosis of CHD and VA. Gas chromatography method was used to measure the content (%) of eicosapentaenoic (EPA) and docosahexaenoic (DHA) polyunsaturated fatty acids (PUFA) in peripheral blood erythrocytes, with the calculation of a summary (EPA + DHA) ω-3 index. All participants underwent 24-hour electrocardiography (ECG) monitoring, with the assessment of maximal, minimal, and mean heart rate (HR), heart rate variability (HRV) parameters (SDNN and pNN50), heart rate turbulence (TO and TS), microvolt T wave alternans (mTWA), and the number of ventricular extrasystoles (VE) and transient and persistent ventricular tachycardia (VT) episodes. All patients also underwent EchoCG.Results.In examined patients, the values of ω-3 index of erythrocytes varied from 1,12% to 6,4% (mean 3,74%, 95% CI 2,02-4,38%). There was a weak correlation between ω-3 index or EPA levels (%) and the HRV parameter of pNN50. In addition, ω-3 index or DHA levels (%) negatively correlated with the daily VE number. The 5:00 AM value of mTWA (II lead, update factor 1/8) weakly correlated withω-3 index and DHA levels. There was a moderate positive correlation between E/A ratio and omega-3 index, or EPA and DHA levels.Conclusion.Patients with CHD and VA were characterised by low ω-3 index values and high (56%) or moderate (44%) levels of cardiovascular risk. The values of ω-3 index positively correlated with the daily VE number and negatively correlated with E/A ratio and pNN50 parameter of HRV.
Contemporary treatment of pulmonary arterial hypertension: the North-West Registry data analysis
Authors: Goncharova N. S. , Kazymly A. V. , Naimushin A. V. , Moiseeva O. M.
Published: October 2019

Aim. Using the prospective Registry data, to assess the effects of conventional and specific therapy on the clinical course and survival of the patients with pulmonary arterial hypertension (PAH). Material and methods. The study included 124 patients (mean age 38,2±13,7 years; 34 men and 78 women): 31 with idiopathic PAH (IPAH), 52 with Eisenmenger syndrome, 17 with inoperable chronic thromboembolic pulmonary hypertension, 9 with PAH and corrected congenital heart disease, 6 with PAH and systemic scleroderma, and 6 with PAH and HIV infection. Results. The cumulative one-year and three-year survival rates were 94% and 75%, respectively. Irrespective of the absence of right heart catheterisation and vasoreactive testing, 42,7% of the patients were treated with calcium antagonists. PAH-specific therapy was administered to 40,3% of the participants (64,5% and 21% of those with IPAH and Eisenmenger syndrome, respectively). PAH-specific therapy was associated with an increase in survival time. Conclusion. In PAH patients, the prognosis is linked to early administration of specific monotherapy and possible combination therapy. Developing a national registry of pulmonary hypertension will facilitate the assessment of the real-world demand for specific therapy and the related costs.
Análise espacial das anomalias congênitas do sistema nervoso
Authors: Lima Luciana Moura Mendes de , Melo Ana Cláudia Oliveira de , Vianna Rodrigo Pinheiro de Toledo , Moraes Ronei Marcos de
Published: September 2019

Resumo Introdução A anomalia congênita do sistema nervoso ocorre durante o desenvolvimento embrionário. O território pode ser um fator determinante e esse conhecimento é importante para o planejamento de ações ou intervenções em saúde pública. Objetivo Detectar aglomerados espaciais da ocorrência das anomalias congênitas do sistema nervoso e caracterizá-las de acordo com as variáveis do Sistema de Informações sobre Nascidos Vivos. Método Estudo ecológico em que foram utilizados os dados do Sistema de Informações sobre Nascidos Vivos no Estado da Paraíba, período entre 2014 e 2016. Para a análise dos dados foram empregados a Razão de Incidências Espacial, a estatística Scan e o teste de Friedman. Resultados Foi constatado que nos anos de 2014 e 2016 os aglomerados espaciais estavam espalhados pelo Estado, enquanto no ano de 2015 ocorreu uma maior concentração desses ao noroeste do Estado. Conclusão A detecção dos aglomerados espaciais pode auxiliar os gestores na identificação de áreas prioritárias no cuidado à saúde de crianças com anomalias congênitas do sistema nervoso.
A prescrição de medicação psicotrópica e o conhecimento da portaria regulatória brasileira por cirurgiões-dentistas
Authors: Avelar Luanne Priscilla Pereira , Castilho Lia Silva de , Abreu Mauro Henrique Nogueira Guimarães , Vilaça Ênio Lacerda , Resende Vera Lúcia Silva , Silva Maria Elisa Souza e
Published: September 2019

Resumo Introdução O uso de psicotrópicos por cirurgiões-dentistas é permitido por lei no Brasil para casos clínicos específicos. São poucos os estudos sobre a sua utilização na odontologia. Objetivo Este estudo investigou a prescrição de psicotrópicos por cirurgiões-dentistas inscritos no Conselho Regional de Minas Gerais e seu conhecimento sobre a Portaria 344/1998. Método Foram enviados aos 15.250 cirurgiões-dentistas um questionário eletrônico com 13 questões abordando a prescrição de psicotrópicos, e foram respondidos 969 questionários. Foram estudados: o tempo de formado, tipo de instituição de graduação, tipo de pós-graduação, medicamentos mais prescritos, conhecimento sobre a Portaria 344/1998 e público mais frequente que recebe a prescrição. Resultados 257 profissionais prescrevem psicotrópicos e 223 conhecem a legislação. Um preocupante percentual de profissionais que prescreve esses medicamentos não conhece o teor da Portaria 344/1998. Os analgésicos opioides são os medicamentos mais prescritos. Os especialistas são os que mais prescrevem psicotrópicos (p=0,015), e aqueles que prescrevem ansiolíticos conhecem a legislação com maior frequência (p=0,003). Os cirurgiões bucomaxilofaciais (p=0,02) e os especialistas em distúrbios da articulação temporomandibular (0,03) são os que mais conhecem a legislação e prescrevem medicação psicotrópica. A dor forte e o medo são as duas principais razões para a prescrição. Conclusão Ser especialista e conhecer a Portaria 344/1998 são fatores associados à prescrição de psicotrópicos entre cirurgiões-dentistas.
Doação de leite humano na perspectiva de profissionais da atenção primária à saúde
Authors: Freitas Maria Imaculada de Fátima , Miranda Wanessa Debôrtoli de , Passos Maria Cristina , Bonolo Palmira de Fátima
Published: September 2019

Resumo Introdução A doação de leite humano envolve valores sociais, conhecimento e organização, tanto para os profissionais de saúde como para as mães doadoras, tornando-se, assim, objeto complexo da atenção à saúde materno-infantil. Objetivo Buscou-se compreender representações de profissionais de saúde da atenção primária sobre a doação de leite humano. Método Esta é uma pesquisa qualitativa na qual foi adotada a teoria proposta por André Petitat sobre o dom. Foram entrevistados 12 profissionais, entre eles enfermeiros, médicos, nutricionistas e agentes comunitários de saúde. Como técnica de análise, adotou-se a análise estrutural da narrativa. Resultados Representações sobre leite humano como objeto de doação se relacionam com o valor nutricional e afetivo deste e com a importância do dom, de modo geral, na sociedade, para se valorizar ou não a prática. A maioria dos profissionais considera que o aconselhamento para doação deve acontecer apenas durante a amamentação, após verificar o excesso de produção láctea, numa representação utilitarista da doação. Representações de produção insuficiente de leite e de leite “fraco” persistem nas ações de cuidado, fazendo os profissionais se distanciarem do aconselhamento para a doação de leite nas oportunidades de criação de vínculo. Conclusão Educação para a saúde que considere a subjetividade dos profissionais e a complexidade dos atos de doar e de amamentar é fundamental para o incremento da doação aos bancos de leite.
Alfabetização Científica e a Contextualização do conhecimento: um estudo da Física aplicada ao trânsito
Authors: Vizzotto Patrick Alves , Mackedanz Luiz Fernando
Published: September 2019

Resumo Apresentamos os resultados de um estudo com egressos do Ensino Médio que buscou investigar o nível de alfabetização científica e a capacidade de interpretar situações do trânsito à luz da Física. A partir desta mensuração, realizamos testes estatísticos a fim de inferir se tais índices possuíam conexão com as aulas de Física que os participantes vivenciaram e também com o grau de informação sobre temas científicos que acreditavam deter. Como resultados, foi possível evidenciar ligações estatisticamente significativas entre a maioria dos constructos analisados, destacando a correlação entre o nível de alfabetização científica de quem assistiu aulas de Física com características que poderiam potencializar uma Aprendizagem Significativa. Como contribuição, defendemos a inclusão de um quarto eixo, o da proficiência científica, no modo de mensurar o nível de alfabetização científica, postulado por Jon Miller, no qual considera alfabetizado cientificamente aqueles que apresentarem domínio mínimo: 1) dos conteúdos da Ciência; 2) da Natureza da Ciência; e 3) do Impacto da Ciência e Tecnologia na Sociedade e meio ambiente.
Thermal requirements and age-specific life tables of cowpea aphids in cowpea under natural field conditions
Authors: Girão Filho José Edmir , Pádua Luiz Evaldo de Moura , Portela Gilson Lages Fortes , Sousa Francinalva de Morais
Published: September 2019

ABSTRACT: Thermal requirements and life tables of insects are important tools in the ecological management of pests. Thus, this study aimed to construct age-specific life tables for Aphis craccivora at different times of the year and, based on their thermal requirements, predict the occurrence of adults under field conditions. To that end, aphids of known age were kept in cages over cowpea plants at different times of the year - November 2016 and March, April, and June 2017 - at the Agricultural Sciences Center of the Federal University of Piauí. Parameters of development, fertility, and mortality were observed daily, allowing us to construct age-specific life tables, as well as an accumulated degree-day model to predict adult occurrence. The time of year affected the first and second stages of development of the cowpea aphid, the nymphal and reproductive periods, longevity, the biological cycle, the number of nymphs produced per female, the daily production of nymphs per female, life expectancy (ex), and survival (Lx). However, the fertility life tables showed significant differences only in the net reproduction rate (R0). The proposed degree-day model reached an accuracy of one day or more than the observed value, with a maximum error of 12.9%. We concluded that the proposed model is adequate to predict the occurrence of adults in the field and that the population parameters of A. craccivora in cowpea are negatively affected during November and positively affected in June.
Adequação da assistência pré-natal em casa de parto e causas associadas com as transferências hospitalares
Authors: Oliveira Tamara Cristina da Matta de , Pereira Adriana Lenho de Figueiredo , Penna Lucia Helena Garcia , Rafael Ricardo de Mattos Russo , Pereira Audrey Vidal
Published: September 2019

Resumo OBJETIVO Analisar a adequação da assistência pré-natal em Casa de Parto e as causas associadas com as transferências maternas e dos recém-nascidos para o hospital. MÉTODOS Estudo transversal dos atendimentos da única Casa de Parto, de 2009 a 2014, no Rio de Janeiro. As análises estatísticas foram pelo Teste χ2 e Razão de Prevalência (RP). RESULTADO A assistência pré-natal adequada predominou (42,8%) e não houve associação (p=0,55) com as transferências. A transferência materna é causada pela bolsa amniótica rota (RP= 2,09; IC 95% 1,62-2,70) e batimentos cardíacos fetais alterados (RP= 3,06; IC 95% 2,13-4,39). As transferências do recém-nascido estão associadas com a presença de mecônio no líquido amniótico (RP= 2,40; IC 95% 1,30 - 4,43); Apgar abaixo de 7 (RP= 5,33; IC 95% 2,65-10,73) e assistência ventilatória ao nascer (RP= 9,41; IC 95% 5,52-16,04). CONCLUSÃO As intercorrências na assistência intraparto são as causas associadas com as transferências.
Hacia una Educación Tropical: ideas sobre formación de animadores socioculturales
Authors: Escobar Javier Orlando Lozano
Published: September 2019

Resumen: Conforme la gestión cultural descubre su dimensión más comunitaria en las cercanías de la educación popular latinoamericana, los estudios sobre la fiesta y el carnaval cobran sentido no solo como patrimonio inmaterial, sino como lugares para el desarrollo de competencias culturales y comunicativas a ser incluidas en el perfil de los gestores culturales. Recupero la experiencia de la asignatura Animación sociocultural, impartida a futuros gestores culturales en la Universidad Nacional de Colombia, sugiriendo caminos a seguir para impulsar cambios culturales que lejos diseminar las normas y folclorizar la diversidad, contribuyan a la pervivencia de pueblos que pueden determinar o incidir en su propio destino, creándolo - incluso también simbólicamente - de nuevo.
A Experiência no Mundo Existencial, Segundo Dewey
Authors: Henning Leoni Maria Padilha
Published: September 2019

Resumo: Este estudo bibliográfico tem por objetivo explicitar a compreensão de Dewey sobre a existência enquanto instância natural onde ocorrem as experiências dos organismos ali encontrados em situação de transação permanente. A existência natural é o mundo da fragilidade, imprevisibilidade, contingências, devido ao conflito de forças opostas, cuja energia sustenta a conservação ou deterioração da vida, motivo do desmerecimento da experiência. Dentre os elementos que compõem a natureza no âmbito da vida se encontram os humanos que, por possuírem a capacidade de desenvolvimento do pensamento investigativo e reflexivo, e favorecidos pela sua natureza plástica, podem alçar ao patamar de aprimoramento na existência social, particularmente pela educação.
Nietzsche e Quine: da naturalização da estética à epistemologia naturalizada
Authors: Barros Fernando R. de M.
Published: September 2019

Resumo Longe de pretender esgotar possíveis semelhanças entre Nietzsche e Quine, o texto que se segue tenciona mostrar, mediante comparações paradigmáticas e admissíveis convergências metodológicas, como ambos os autores, lançando mão de hipóteses naturalistas para interpretar o conhecimento e a estética, respectivamente, tornam possível pensar num naturalismo menos confinante e mais inventivo, livre dos prejuízos do cientificismo e mais condizente com a sensibilidade artística em geral.
A ciência contra e metafísica: Nietzsche e o filosofar histórico Em Humano, demasiado humano I
Authors: Mignoni Neomar Sandro
Published: September 2019

Resumo Com Humano, demasiado humano I, Nietzsche estabeleceu sua definitiva ruptura com a metafísica de Schopenhauer e a arte de Wagner, ao mesmo tempo que concedeu à ciência maior destaque para que, juntamente com o filosofar histórico, pudesse lhe servir de principal aliada no combate aos erros e excessos da metafísica, da religião e da arte, sobretudo a romântica. O presente estudo pretende investigar como Nietzsche relaciona algumas características que vê na ciência de sua época com sua proposta de filosofia histórica, a qual se contrapõe à metafísica tradicional.
Nietzsche e o ecstase: o trágico a partir de uma reinterpretação dos conceitos de phobos e eleos
Authors: Carneiro Rafael Vieira Menezes
Published: September 2019

Resumo Pretendemos, neste artigo, expor a noção trágica nietzschiana na conferência O Drama Musical Grego e os fragmentos póstumos escritos no mesmo período, mostrando que o desenvolvimento dessa concepção caminha peri passu à crítica ao pensamento moderno. Essa crítica é realizada por meio do conceito de ecstase, o qual se confronta com a ideia de tragédia entendida a partir da poesia, Deste modo, exporemos como Nietzsche articula o seu conceito de ecstase como um contraponto à compreensão moderna da “Poética” de Aristóteles, assim como as suas aproximações e distanciamentos da filosofia schopenhaueriana ao formular sua concepção trágica.
CLINICAL UTILITY OF RISK SCORES IN VARICEAL BLEEDING
Authors: CHANDNANI Sanjay , RATHI Pravin , UDGIRKAR Suhas Sudhakarrao , SONTHALIA Nikhil , CONTRACTOR Qais , JAIN Samit
Published: September 2019

ABSTRACT BACKGROUND: Variceal bleeding remains important cause of upper gastrointestinal bleed. Various risk scores are used in risk stratification for non-variceal bleed. Their utility in variceal bleeding patients is not clear. This study aims to compare probability of these scores in predicting various outcomes in same population. OBJECTIVE: This study aims to compare probability of these scores in predicting various outcomes in same population. To study characteristics and validate AIMS65, Rockall, Glasgow Blatchford score(GBS), Progetto Nazionale Emorragia Digestiva (PNED) score in variceal Upper Gastrointestinal Bleed (UGIB) patients for predicting various outcomes in our population. METHODS: Three hundred subjects with UGIB were screened prospectively. Of these 141 patients with variceal bleeding were assessed with clinical, blood investigations and endoscopy and risk scores were calculated and compared to non-variceal cases. All cases were followed up for 30 days for mortality, rebleeding, requirement of blood transfusion and need of radiological or surgical intervention. RESULTS: Variceal bleeding (141) was more common than non variceal (134) and 25 had negative endoscopy. In variceal group, cirrhosis (85%) was most common etiology. Distribution of age and sex were similar in both groups. Presence of coffee coloured vomitus (P=0.002), painless bleed (P=0.001), edema (P=0.001), ascites (P=0.001), hemoglobin <7.5 gms (P<0.001), pH<7.35 (P<0.001), serum bicarbonate level <17.6 mmol/L (P<0.001), serum albumin<2.75 gms% (P<0.001), platelet count <1.2 lacs/µL (P<0.001), high INR 1.35 (P<0.001), BUN >25mmol/L (P<0.001), and ASA status (P<0.001), high lactate >2.85 mmol/L (P=0.001) were significant. However, no factor was found significant on multivariate analysis. Rockall was found to be significant in predicting mortality and rebleed. AIMS65 was also significant in predicting mortality. GBS was significant in predicting blood transfusion and need of intervention. PNED score was significant in all events except mortality. CONCLUSION: All four scores had lower predictive potential in predicting events in variceal bleed. However, AIMS65 & Rockall score were significant in predicting mortality, while GBS in predicting need of transfusion and intervention. PNED score was significant in all events except mortality.
Selectivity of Herbicides to Native Tree Species in Brazil
Authors: OLIVEIRA L. , SILVA JR A.C. , GONÇALVES C.G. , PEREIRA M.R.R. , MARTINS D.
Published: September 2019

ABSTRACT: Weeds are one of the main obstacles in the recovery of degraded areas. This research aimed to study the selectivity of herbicides on Trema micrantha (Jamaican nettletree), Schinus molle (Peruvian peppertree), and Apuleia leiocarpa (garapeira) seedlings. An experiment was installed in Junqueirópolis and another in Jaboticabal/SP, Brazil. The experimental design used was completely randomized design with four replications. Treatments consisted of clethodim + fenoxaprop-p-ethyl (50 + 50 g a.i. ha-1), sethoxydim (184 g a.i. ha-1), quizalofop-p-ethyl (75 g a.i. ha-1), nicosulfuron (50 g a.i. ha-1), fluazifop-p-butyl (125 g a.i. ha-1), fomesafen (225 g a.i. ha-1), haloxyfop-methyl (48 g a.i. ha-1), bentazon (720 g a.i. ha-1), chlorimuron-ethyl (15 g a.i. ha-1), and control without herbicide. The analyzed characteristics were stem diameter, plant height, and phytointoxication at 7, 14, 21, 28, 35, and 42 days after herbicide application (DAA), in addition to shootdry matter accumulation in seedlings at the end of the study. Nicosulfuron and chlorimuron-ethyl caused intoxication in all the studied tree species. In Jaboticabal, these herbicides impaired the initial growth of Jamaican nettletree seedlings, while no herbicide delayed its initial development in Junqueirópolis.A similar result was obtained regarding dry matter accumulation for garapeira in both cities. The herbicides clethodim + fenoxaprop-p-ethyl and sethoxydim decreased dry matter accumulation in Peruvian peppertree plants in Jaboticabal and Junqueirópolis, respectively, thus not being recommendedtheir use for these species.
Acute Toxicity of Herbicides and Sensibility of Aquatic Plant Wolffia brasiliensis as a Bioindicator Organism
Authors: PEREIRA P.C. , BRUNETTI I.A. , CASTRO K.S. , CHIAROTTI L.F. , SANTOS B.E. , MORAES J.C. , CRUZ C.
Published: September 2019

ABSTRACT: This study aimed to establish the mass cultivation of Wolffia brasiliensis under laboratory conditions, determine the sensitivity of reference substances (potassium dichromate, sodium chloride, and potassium chloride), and estimate the acute toxicity (LC50;7d) for the herbicide glyphosate, diquat, paraquat, imazapyr, 2,4-D, saflufenacil, imazamox, penoxsulam, metsulfuron-methyl, and atrazine. Three media were tested for culture establishment: Hoagland’s medium, 5.0 g L-1 NPK fertilizer (20-5-20), a mixture of Oxisol + organic substrate of decaying aquatic plant (2:1; v v-1). Sensitivity tests with reference substances and acute toxicity for herbicides were carried out after establishing the cultivation. The species W. brasiliensis presented an excellent sensitivity response to reference substances, with means of LC50;7d of 15.61±2.13 g L-1, 17.02±0.50 g L-1, and 52.54±4.27 mg L-1 for sodium chloride, potassium chloride, and potassium dichromate, respectively. The acute toxicity response indicated that W. brasiliensis was extremely sensitive to diquat (LC50;7d = 0.07 mg L-1) and paraquat (LC50;7d < 0.05 mg L-1), sensitive to imazapyr (LC50;7d = 21.10 mg L-1), and little sensitive to the other herbicides. The response capacity for the different groups of herbicides, the standardized response to reference substances, and ease of cultivation in the laboratory indicate the potential for using this aquatic plant in the assessment of herbicide risk in aquatic environments.
Potentialities of low invasive fixation of the anterior pelvic ring with threaded pin
Authors: Solod E. I , Lazarev A. F , Petrovskiy R. A , Ovcharenko A. V , Abdulkhabirov M. A , Alsmadi Ya. M
Published: October 2019

Purpose of study: to present the first experience of using the proposed method of pubic bones fixation and to determine the potentialities of its practical application. Patients and methods. During the period from 2016 to 2018 twenty patients (mean age 33.48 ± 10.85 years) with pelvic ring injuries were operated on. In all cases the pubic bones osteosynthesis with threaded pins was performed. In 15 (75%) cases the fractures (1980) were of type B1, in 5 (25%) - type C1 by Tile classification. In 14 (70%) patients the fractures of the pubic bones corresponded to Nakatani II, in 6 (30%) - Nakatani I. The quality of the reposition was assessed by Tornetta-Matta criteria and functional results were evaluated by Majeed score. The follow-up period varied from 6 to 24 months (14.2±5.6 months). Results. The average duration of fixation procedure of the pubic bone made up 10.4±4.2 min; the average volume of intraoperative blood loss in one pubic bone fixation was 6.3±1.4 ml. In all cases excellent and good reposition was achieved. In no one case the fixator migration was observed. Twelve months after surgery the functional results by Majeed score were assessed as excellent (15) and good (4) in 19 followed up patients. Conclusion. The use of the proposed method of the pubic bones fracture fixation with threaded pins can be recommended for patients with Nakatani I, II fresh fractures in the absence of soft tissue interposition. Rigid fixation of fragments with minimal risk of fixator migration provides conditions for early rehabilitation of patients and enables to achieve excellent and good functional results.
ОБ ЭФФЕКТИВНОСТИ ПОДДЕРЖКИ СУБЪЕКТОВ ПРЕДПРИНИМАТЕЛЬСТВА ОРГАНАМИ МУНИЦИПАЛЬНОЙ ВЛАСТИ
Authors: Аваков Сергей Юрьевич , Зимовец Александр Владимирович
Published: September 2019

Цель: статья посвящена проблемам субъектов малого и среднего предпринимательства в условиях перманентного кризиса отечественной экономики. Обсуждение: в работе анализируются потребности субъектов малого и среднего предпринимательства в государственной поддержке, определяются приоритетные ее направления. Основной акцент делается на изучении и анализе существующих программ поддержки и их известности в предпринимательской среде. Так же выявляются факторы, влияющие на динамику количества предприятий, получающих финансовую и консультационную поддержку на муниципальном уровне. Результаты: проведенное исследование подтверждает, что многие собственники бизнеса до сих пор плохо разбираются во всех тонкостях существующих программ государственной поддержки предпринимательства. Вследствие этого авторами делается ряд предложений по повышению прозрачности условий получения государственной поддержки субъектов малого и среднего предпринимательства.