bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review Study Narrativity In Teaching English Grammar
Authors: Fenjan Lecturer: Sahab Salih
Published: December 2024

Language is a set of functions, the most prominent and important of which are narration, description, dialogue and argumentation. Perhaps looking at language as a set of functions helps of making the process of acquiring it an enjoyable, interesting and useful process. Hence, modern educational studies have come to facilitate language training by using dialogue, acting and storytelling methods. This article adopts previous studies based on the importance of using stories in teaching and learning English grammar in the different school grades. So it is set to provide a brief critical review of the benefit of narrative technique. One of the functions that this review is addressed to tackle the narration function, which is a trend for the intermediate, the advanced level, and a building block for the distinguished level.
Blockchain Technology and Improving Human Resource Development Processes Field study on Jordanian Banks
Authors: Alhyasat Dalia Ibrahim Dheif Allah
Published: December 2024

The study examined the impact of blockchain technology on four human resource development processes in Jordanian banks. A quantitative approach was used, relying on a questionnaire survey of 158 employees from Jordanian banks, to test four hypotheses related to the relationship between blockchain technology and human resource development processes. The results showed that blockchain technology had a moderately positive relationship with all four human resource development processes, and all four hypotheses were partially accepted. The findings were consistent with previous studies on the role of blockchain technology in human resource management and development. The study revealed that blockchain technology can enhance the security, efficiency, and transparency of human resource development processes, as well as improve the performance, accountability, and innovation of both employees and organizations. However, the study also pointed out that blockchain technology presents certain challenges and barriers to human resource development processes, which require organizations to invest in resources, training, and communication to overcome. The study concludes that blockchain technology is a valuable and innovative tool for human resource development, though its generalizability is limited due to the focus on Jordanian banks.
آثر التسويق الإلكتروني على الأداء المؤسسي دراسة تطبيقه على المصارف العاملة بولاية الجزيرة 2023م
Authors: حياتي د. عمر نور الدائم , حمدي د. عبد الرحمن محمد عبد الله , البدوي أ. هناء عمر احمد
Published: December 2024

تناولت الدراسة آثر التسويق الإلكتروني على الأداء المؤسسي دراسة تطبيقه على المصارف العاملة بولاية الجزيرة، وأن التسويق الإلكتروني يمثل سمة العصر الحديث التي تأثر بها الناس كثيرا، فقد تمثلت مشكلة الدراسة في السؤال التالي: ما هو أثر التسويق الالكتروني على الاداء المؤسسي؟ هدفت هذه الدراسة إلي الكشف عن أثر الخدمة الإلكترونية في الأداء المؤسسي، ومن أجل تحقيق أهداف الدراسة تم تصميم استبانة وتوزيعها على عينة الدراسة المتمثلة في 150 استبانة وتم استخدام المنهج الوصفــي التحلي، حيث طبقت هذه الدراسة على الموظفين الإداريين بالمصارف التجارية في الولاية - بنكك الخرطوم، البنك الزراعي السوداني، بنك الإذخار والتنمية الاجتماعية، وقد أظهرت الدراسة وجود أثر قوي للتسويق الإلكتروني على تحسين أداء المصارف التجارية بولاية الجزيرة، وتمثلت أهم التوصيات في ضرورة الاهتمام بتطوير الخطة الاستراتيجية للمصاريف وتحديد معايير محدد لتقييم الأداء المؤسسي.
Strategies of Improving Psychological Well-Being among Female Teachers in Educational Environment: A Descriptive Exploratory Study
Authors: Al-Ubaidani Kawthar , Youssef Mohammed
Published: December 2024

The study aimed to identify the strategies needed to improve the psychological well-being of female teachers in the educational environment, focusing on surveying the opinions of some female teachers. To achieve the study's goal, the descriptive approach was used, and the study reached a set of results, the most prominent of which are: There are many strategies needed to improve the psychological well-being of female teachers in the educational environment, such as starting with promoting respect and cooperation among colleagues. You can do this by providing assistance and support to others, exchanging ideas and knowledge, and forming good relationships; Achieving the psychological well-being of female teachers in the educational environment is linked to the reality of their psychological well-being in daily life and outside the educational environment, as good relationships can help build a sense of belonging and appreciation. The study also recommended a set of recommendations, the most prominent of which are: the necessity of making continuous learning an indispensable habit in the daily life of the teacher; and paying attention to building healthy social relationships and investing in them regularly between female teachers in the work environment with each other and even with the outside community in a way that positively reflects on the performance of information within the work environment; Integrating female teachers into sports classes or allocating sports classes for them according to their needs. They can seek the help of sports experts and psychological support to choose the sports that suit them. Sports equipment can be used if necessary, as practicing sports will balance the mental and physical pressure on female teachers in the educational environment.
دراسة الأساليب الدلالية في دالية المتنبي (لكل امرئ من دهره ما تعودا)
Authors: أبو صعيليك أمل , مناع هاشم
Published: December 2024

تنبع أهمية البحث من تناوله المستوى الدلالي لدالية المتنبي بالدراسة الأسلوبية؛ لإماطة اللثام عن المكتنزات الجمالية التي تضمنتها القصيدة، ضمن أداة إحصائية؛ لأنها لم تدرس كما تزمع الباحثة دراستها، ويهدف البحث إلى تتبع تحليل المستوى الدلالي للقصيدة، وتبيين الأساليب اللغوية المتنوعة في القصيدة التي تميزت من غيرها، وإظهار القيمة الجمالية في تنوع أغراضها.
واتبعت الدراسة المنهج الوصفي التحليلي القائم على الوصف والتحليل، وتوصلت الدراسة إلى مجموعة من النتائج أبرزها:

الإنشاء الطلبي بأساليبه: الأمر، والاستفهام، والنداء، والنهي، والتعجب، والتشبيهات والاستعارات، وبعض المحسنات البديعية، والحقول الدلالية، تتآزر فيما بينها؛ لتكشف عن بواطن القصيدة التي لم تذكر صراحة.

تعددت الأغراض الشعرية في القصيدة، مما انعكس على تعدد الحقول الدلالية المفصحة عن رغبات الشاعر.

   شكلت الاستعارة المكنية والتمثيلية ملمحًا أسلوبيًّا بارزًا في القصيدة، فكشفت عن براعة المتنبي في مخالفة المألوف، فكانت حُبلى بدلالات متعددة وممتدة قابلة للتأويل، وأخرجت القول عن نمطية الخطاب المعروف، وانتشلت النص من درك التقريرية الأسفل إلى سماوات الشعرية الفاتنة.

The importance of the study stems from its approach to the semantic level of Al-Mutanabbi's poem through a stylistic study; to uncover the aesthetic treasures contained in the poem, within a statistical tool; because it was not studied as the researcher intends to study it, and the study aims to track the analysis of the semantic level of the poem, and to clarify the various linguistic styles in the poem that distinguished it from others, and to show the aesthetic value in the diversity of its purposes.
    The study followed the descriptive analytical approach based on description and analysis, and the study reached a set of results, the most prominent of which are:
1) The request construction with its styles: command, question, call, prohibition, exclamation, similes and metaphors, and some rhetorical embellishments, and semantic fields, work together to reveal the depths of the poem that were not explicitly mentioned.
2) The poetic purposes in the poem were multiple, which was reflected in the multiplicity of semantic fields that reveal the poet's desires.
3) The metaphorical and figurative metaphor formed a prominent stylistic feature in the poem, revealing Al-Mutanabbi’s skill in going against the norm, as it was full of multiple and extended meanings that were open to interpretation, and took the statement out of the stereotype of known discourse, and rescued the text from the lowest depths of reporting to the heavens of captivating poetry.
إسهام التعبير الجرافيكي الرقمي في تنمية التفكير المجالي لدى متعلمي السلك الثانوي التأهيلي -الخريطة التفاعلية أنموذجا-
Authors: وريض نزهة , عبد العزيز باحو , شكير عكي
Published: December 2024

هدفت الدراسة إلى التعرف على "إسهام التعبير الجرافيكي الرقمي في تنمية التفكير المجالي لدى متعلمي السلك الثانوي التأهيلي -الخريطة التفاعلية أنموذجا-". وقد اعتمدنا المنهج الوصفي التطويري، حيث حاولنا أن نؤصل لموضوع الدراسة انطلاقا من الأدبيات التربوية الجغرافية المؤطرة لمفهوم النهج الجغرافي، وكذا الخريطة التفاعلية. كما قدمنا نموذجا ديدكتيكيا تطبيقيا، يبرز دورها في ترسيخ النهج الجغرافي لتنمية التفكير المجالي لذات المتعلمين/ات بالمستوى الثانوي التأهيلي. وتوصلت الدراسة إلى مجموعة من النتائج أبرزها: أن إنتاج خرائط تفاعلية رقمية وتوظيفها في الدرس الجغرافي، يساهم في رقي الجغرافيا إلى مادة وظيفية تلامس التطور الذي يعرفه الواقع بجميع ميكانيزماته المختلفة، وذلك من أجل مواكبة التطورات الهائلة التي تسجلها الجغرافيا.
The study aimed to identify “Input of the Digital Graphic Expression in the development of spatial thinking among secondary school learners- the Interactive Map Inmogda- “Using the descriptive development approach, we tried to relate the topic back to its origine. Based on the geographical educational literature, framing the concept the geographical approach. In addition to the interactive map.  we provided a didactical practical example. That highlights the role of the interactive map in consolidating the geographical approach, in developing spatial thinking among secondary school learners.
The study came up with a set of results, most notably: Producing digital Interactive Maps and employing them in the Geography lesson will contribute to elevating Geography to a functional subject that touches the development of reality with all its different mechanics. In order to keep abreast of the enormous developments in the Geography.
معايير اختيار الطرق التربوية في تدريس المباحث الفقهية
Authors: عدي حسن
Published: December 2024

إن تدريس المباحث الفقهية يتم اختيارها مراعاة لجملة من المعايير التربوية والمعرفية، فمنها ما يخص القصد التعليمي والهدف التعليمي؛ لأننا في نهاية التعلم نتحدث عن الهدف المعرفي والمهاري والوجداني القيمي، وأيضا مراعاة الفروق الفردية وهو معيار نفسي يؤثر في الاختيار بين المباحث الفقهية في سياق التدرج، ومعيار طبيعة المحتوى الفقهي الذي يحمل الأثر البليغ في الانتقاء ويفرض خصوصية المادة المدرسة  في التدريس معرفيا ومنهجيا وتربويا، على أن هذه معاير تشكل نسقا متكاملا وكمقاربة متكاملة الأطراف، لا ينفصل بعضها عن البعض الآخر. وقد  خلص هذا البحث إلى ضرورة استصحاب المدرسين لعلم؛ لفقه هذه المعايير  والاحتكام لها حتى تكون اختياراتهم معللة مبنية على وعي علمي في الممارسة المعقلنة؛ مما يفيد  العلاقة والارتباط بين الشموخ المعرفي والإبداع التربوي في خصوصيات علم الفقه ونسقها التربوي من حيث مسالك التعليم والتعلم.
The jurisprudential topics are selected taking into account a set of educational and cognitive criteria, including those related to the educational intent because at the end of learning we are talking about the cognitive, skill and emotional goal, and also taking into account individual differences, which are  psychological criterion that affect the selection between jurisprudential topics in the context of gradation and others, and the criterion of the nature of the jurisprudential content, which is a cognitive criterion that affects the selection and imposes the specificity of science in teaching cognitively, methodologically and educationally, as they are criteria that form an integrated system, some of which are not separate from each other, in the context of an educational jurisprudential approach that values ​​the specificity of the jurisprudential lesson in educational practice.Keywords: educational methods, jurisprudential topics, teaching methods, teaching Sharea sciences, education, Jurisprudence.
Developing a Mobile Application for Project Bidding and Service Matching
Authors: POPÎRLAN Claudiu Ionuț
Published: December 2024

The rise of the gig economy and the increasing demand for flexible, remote work have transformed the freelancing landscape. This paper presents the development of a mobile application designed to streamline the process of project bidding, user management, and service matching for freelancers. Built using Java and Android Studio, the application employs Agile development methodologies to ensure robust performance and a seamless user experience. Key features include user registration and verification, a secure project-bidding platform, and efficient database management with SQLite. The app also utilises the Glide library for optimised image handling, ensuring smooth interaction for freelancers and clients alike. Initial results indicate that the platform effectively connects clients with freelancers by providing an intuitive, reliable, and secure service-matching environment. This paper explores the technical design, challenges, and future directions of the application, emphasising its potential to improve freelancing workflows and address key issues such as decision fatigue and trust in digital platforms.© The Author(s) 2024. Published by RITHA Publishing. This article is distributed under the terms of the license CC-BY 4.0., which permits any further distribution in any medium, provided the original work is properly cited maintaining attribution to the author(s) and the title of the work, journal citation and URL DOI.
Advancing Multi-Level Production Defect Detection Using Quality Tools and Maintenance Optimisation
Authors: FADWA Elleuch
Published: December 2024

This study aims to advance the detection of production defects at three levels - part, material, and machine - through the application of a few quality tools with a view to proposing solutions. The research focuses on identifying and addressing the most prevalent and critical anomalies observed in the workshop. Despite existing quality control measures, production often falls short of meeting customer specifications due to machine malfunctions, inadequate operator vigilance, and inefficiencies in the maintenance processes. These challenges underscore the need for a systematic approach to visualise and address production system issues. By applying targeted quality tools, this paper seeks to optimize maintenance strategies and improve overall production performance, contributing to enhanced operational efficiency and product quality.© The Author(s) 2024. Published by RITHA Publishing. This article is distributed under the terms of the license CC-BY 4.0., which permits any further distribution in any medium, provided the original work is properly cited maintaining attribution to the author(s) and the title of the work, journal citation and URL DOI.
BASIC PRINCIPLES OF INTEREST AND INTEREST-FREE FINANCE TODAY
Authors: Şahin Osman Nuri , Adıgüzel Ahmet Uğur
Published: December 2024

Traditional interest-based financial systems, while crucial for economic growth, introduce significant risks and contribute to the gap between financial markets and the real economy. In contrast, interest-free financial systems, which avoid interest and speculative activities, offer potential advantages in minimizing risks and promoting financial stability. The Islamic financial system, grounded in Sharia principles, utilizes profit-sharing, leasing, and sales techniques instead of interest, and is gaining traction worldwide for its resilience against financial crises and its promotion of social and economic justice.
The study explores the foundational principles and global perspectives of interest-free financial systems. The research examines the historical development of banking systems in Turkey and globally, highlighting the rise of participation (Islamic) banking. Participation banks operate on a profit-sharing basis, providing an inclusive financial environment for interest-sensitive individuals. Despite their potential, more research is needed to address the inherent challenges and further develop the interest-free financial system.
Patent Development Strategy through PCT (Patent Cooperation Treaty) International Registration System: Challenge for Intellectual Property (IP) Attorneys in Indonesia
Authors: Margono Suyud
Published: December 2024

This research addresses the role of Intellectual Property (IP) Lawyers in patent registration and prosecution, particularly in the Patent Cooperation Treaty (PCT) context. In a complex research and development environment, an understanding of the risk of patent imitation is essential. This study aims to analyze the strategy of international patent registration through the PCT system and evaluate its effectiveness compared to national patent registration in Indonesia. This research uses a normative legal approach by analyzing the literature and practical aspects relating to international patent registration through the PCT system. The research findings show that Intellectual Property Lawyers need to have in-depth knowledge of the national and international patent registration systems. The research also highlights the challenges for inventors with limited budgets in choosing between national Patent and PCT registration, as well as the importance of strategic planning in registration to protect innovation. This research underscores the important role of IP Attorneys in assisting inventors through the patent registration process, both nationally and internationally, and emphasizes that the PCT system is a viable option to effectively protect innovation while managing costs.
Legal Protection for Victims of Online Gender-Based Violence (Cyber-Based Violence)
Authors: Rahman Alip , Sutrisno Anom , Martia Lita , Wangi Feri
Published: December 2024

Online gender-based violence is a serious problem that negatively impacts victims physically, psychologically and socially. This research aims to analyze the legal protection of victims of cyber-based violence in Indonesia, focusing on existing regulations and their implementation. The method used in this research is a normative research method with a juridical-analytical approach, where data is collected through a literature study of relevant laws and regulations, legal documents, and previous research related to online gender-based violence. The results show that Law No. 12 of 2022 on the Crime of Sexual Violence provides a strong legal basis for victim protection, including the right to assistance, temporary protection, and recovery. In addition, regulations regarding the removal of content involving victims are an important step in reducing further impact. However, this research also found challenges in law enforcement, public awareness, and training of law enforcement officers that need to be strengthened in order for victim protection to be implemented effectively. This research is expected to contribute to improving the understanding and effectiveness of legal protection for victims of online gender-based violence in Indonesia.
The Role of Global Ambassador and Brand Ambassador for Indonesian and Malaysian Youth
Authors: Nurfalah Farida , Nuruzzaman M. , Khumayah Siti , Sulintang Rhevallino Daneztha , Yunos Mohd Naufal Bin
Published: December 2024

The growing digital era, the role of influencer marketing has become one of the most effective marketing strategies and one of the important aspects in influencer marketing is the involvement of Global Ambassadors and Brand Ambassadors. This study aims to explore the implementation of the role of Global Ambassadors and Brand Ambassadors for Young People in Indonesia and Malaysia. The research methodology was carried out through the first stage, namely observation, development and use of the theory of global ambassadors and brand ambassadors ranging from providing testimonials, providing encouragement and reinforcement (Endorsement), acting as actors in the advertising topics they represent. The second stage is to test the theory through interviews to get feedback, visual representations, and problem-solving creativity that can identify opportunities that exist and be applied in business. The results of this study show that Global ambassadors play a major role for Indonesian and Malaysian youth, especially in shaping their lifestyle image and identity, encouraging consumption of international products, and shaping global trends. However, young people retain local cultural values that influence their perception of products and brands.
Avusturya Feodal Sistemi ve Geleneksel Soyluluk Unvanlarının İncelenmesi
Authors: Şengöz Murat
Published: December 2024

Bu çalışma, Avusturya’daki feodal sistemin ve soyluluk unvanlarının tarihsel gelişimini, sosyal, ekonomik ve politik etkilerini derinlemesine incelemektedir. Feodalizm, Ortaçağ Avrupa’sında toplumsal ve ekonomik yapıyı şekillendiren temel unsurlardan biridir. Avusturya’da Habsburg Hanedanlığı, feodal yapıyı etkili bir şekilde yöneterek, merkezi otoriteyi güçlendirmiş ve yerel yönetimlerin bağımsızlıklarını korumalarına olanak tanımıştır. Bu süreçte, soyluluk unvanları önemli bir rol oynamış, toprak sahipliği ve toplumsal hiyerarşi ile ilişkilendirilmiştir. Çalışma, Habsburglar’ın stratejik evlilikler ve askeri ittifaklar aracılığıyla topraklarını genişlettiğini, böylece feodal ilişkilerin dinamiklerini ve soyluluk sisteminin işleyişini belirlediğini vurgulamaktadır. Modern dönemde ise feodal kalıntılar, toplumsal ve kültürel mirasın bir parçası olarak varlığını sürdürmektedir. Bu bağlamda, feodalizmin yansımaları günümüz Avusturya’sında hala hissedilmekte ve Habsburgların tarihsel etkileri, ulusal kimliğin bir parçası olarak önemli bir rol oynamaktadır. Sonuç olarak, Avusturya’daki feodal sistem ve soyluluk kavramı, hem tarihi bir süreç hem de günümüzdeki toplumsal yapının karmaşıklığını anlamak için kritik bir öneme sahiptir.
Sinekli Bakkal Romanında Rabia’nın Payına Düşen	Genetik Miras ve Çevre Faktörü
Authors: Çetin Derya
Published: December 2024

İnsanlar, doğdukları aileye ve yaşadıkları çevreye göre şekillenen bireyler olarak kabul edilirler. Birey bilincinin kazanılması sürecinde, bu iki temel faktör kişinin varlığında, etkilerinin gücüne bağlı olarak rol oynar. Bu süreç ilerledikçe, bu etkilerin izlerini kişinin yaşamının ve deneyimlerinin farklı aşamalarında görmek mümkündür. Bu izler bazı durumlarda net bir şekilde gözlemlenebilirken, diğerlerinde daha belirsiz olabilir, bu izlerin bu gibi durumlarda dikkatlice tespit edilmesi gerekir. Özellikle erken Cumhuriyet dönemi romanlarında çevresel faktörlerin karakterlerin şekillenmesinde önemli bir etkisi vardır ve bu etki yaşanan dönemin etkisiyle ortaya çıkar. Halide Edib'in Sinekli Bakkal romanındaki Rabia, hem ailesinden miras aldığı karakteristik özellikler hem de yaşadığı çevre nedeniyle anlatıda özel bir yere sahiptir. Roman boyunca hem dönemin tanığı hem de gerektiğinde döneminin sözcüsü olan kahramanımız hem genlerinden gelen özelliklerle hem de bulunduğu çevrenin etkileriyle dikkat çekici bir kimlik kazanır. Sinekli Bakkal, dönemi birçok açıdan yansıtmanın yanı sıra, Rabia’yı yaşadığı çevre ve deneyimleri nedeniyle bağımsız bir karakter olarak değerlendirmemizi gerekli kılar. Rabia’nın gelişimi ve değişimi, aynı zamanda onun içinde bulunduğu çevre hakkındaki bakış açımızı da değiştirir. Bazen olayları Rabia'nın perspektifinden değerlendiririz, bazen de Rabia'yı olaylar karşısında değerlendiririz ve bu durum, onu analiz etmemize neden olur; kahramanımızı analiz ederken, genetik ve çevresel faktörler ön plana çıkar.
Crocin Enhances Cisplatin-Induced Chemosensitivity in Human Cervical Cancer Cell Line
Authors: mollaei homa , Houshyar Reyhaneh , Abedini Mohammad Reza , Safaralizadeh Reza
Published: December 2024

Background: Anti-tumor effects of crocin have been investigated in different tumors; however, its precise molecular mechanism is not exactly elucidated. Objectives: In the present investigation, we have studied pro-apoptotic and anti-proliferative properties of crocin and cisplatin combination on cervical cancer cells. Methods: Cell viability and apoptosis assays were monitored by MTT, Hoechst 33258 staining methods, respectively. The expression levels of apoptotic related genes, including Bax, Bcl-2, p53 mRNA, and miR-365 were analyzed by quantitative reverse transcription- polymerase chain reaction (qRT-PCR). Using Western blot, we have also assessed the protein expression of the above apoptotic genes. Results: The results of this study demonstrated that the combination treatment of cells with crocin and cisplatin significantly reduced the proliferation of cancer cells and induced apoptosis. Furthermore, the Bax/Bcl-2 ratio and the mRNA level of p53 markedly increased in treated cells, whereas it decreased miR-365 expression, an upstream regulator of Bcl2 and Bax. Conclusions: Accordingly, crocin could be a potential candidate for more evaluations such as in vivo studies, since it shows a proper in vitro anticancer effect. It is also suggested that a combination of crocin and cisplatin could be applied as an effective and promising chemotherapy strategy.
Efficacy of Acceptance and Commitment Therapy on Breast Cancer Female Patients’ Hope
Authors: Nemati Fateme , Fallah Tahereh , Montazer Abbas , Dehghani Fahimeh
Published: December 2024

Background: Breast cancer is one of the most serious diseases that can endanger physical, psychological, and social health of women suffering from this disease. Objectives: The aim of this study was to evaluate the effectiveness of commitment and acceptance (ACT) on breast cancer patients’ hope. Methods: This quasi-experimental study included all patients with breast cancer who were inhibited in Yazd, Iran. Using convenience sampling, 34 patients were selected and randomly divided into two groups: the treatment group and the control group. Both groups completed Miller’s questionnaire on hope. Treatment group received psychological therapy of ACT for 12 weeks, 3 hours per week. Miller’s questionnaire was redistributed and completed again by both groups after completion of the treatment. The collected data were analyzed by SPSS software and running analysis of covariance. Results: The results of the current study revealed significant differences between control and treatment groups in terms of pre-test and post-test scores (P = 0.05). Conclusions: According to the results of the present study, psychological therapy of ACT can be useful in promoting the breast cancer patients’ hope.
Histopathological Study of Hydroalcoholic Extract of Terminalia catappa Leaves in Treatment of Indomethacin-Induced Gastric Ulcer in Rats
Authors: SistaniKarampour Neda , Gholamhoseyni Amin , Arzi Ardeshir , Rezaei Anahita
Published: December 2024

Background: Traditional medicine discussed in the literature introduced Terminalia catappa (TC) L. as an antiulcer plant. Objectives: In this study, we investigated the activity of hydroalcoholic extract from TC leaves against indomethacin-induced gastric ulcers in rats. Methods: Animals were divided into 13 groups, each consisting of six rats. The rats fasted for 48 hours. Various doses of Terminalia catappa leaf extract (TCLE) (100, 200, 400, and 600 mg/kg), ranitidine (50 mg/kg), and normal saline (5 mL/kg) were administered orally to the assigned group of rats. Indomethacin (30 mg/kg) was administered to all six groups before treatment. Other groups received only TCLE (100, 200, 400, and 600 mg/kg), ranitidine (50 mg/kg), CMC (1% solution), or indomethacin. Five hours after the drugs were administered, the animals’ stomachs were opened through the large curvature and lesions were observed. One-way ANOVA and LSD tests were used for data analysis, and the minimum significance level was P < 0.05. Results: The results showed that all doses of TCLE and ranitidine had a significant effect (P > 0.05) against the gastric damage caused by indomethacin. There was no significant difference (P > 0.05) between TCLE (400 mg/kg) and ranitidine. Conclusions: The flavonoids, saponins, tannins, alkaloids, and antioxidant properties of TCLE can decrease some of the effects of an indomethacin-induced gastric ulcer.
Formulation and Evaluation of an Iranian Traditional Dosage Form Containing Linum and Ficus for Improvement of Functional Constipation
Authors: Yassa Narguess , Tofighi Zahra , Golabi Motahareh , Toliyat Tayebeh , Naseri Mohsen
Published: December 2024

Background: Constipation is a common gastrointestinal problem worldwide. Objectives: The current study aimed to prepare a dosage form containing flaxseed and figs and evaluate the effects of this drug to treat functional constipation. Methods: A total of 10 formulations were developed using various proportions of excipients by wet granulation method. The best formulation containing 300 mg flaxseed powder and 1200 mg figs extract (total weight of 2000 mg) was selected. After compression of caplets, evaluation tests such as general appearance, hardness, thickness, weight variation, friability, disintegration time and standardization studies were performed. During clinical study, 15 patients with functional constipation received the prepared dosage form three times daily for two weeks, and then statistical differences within the groups were compared. Results: After the first week of experiment the increase of defecation frequency and reduction of retentive posturing, large fecal mass, pain feeling during evacuation and consistency of stool were significantly noticeable (P < 0.05). Conclusions: Prepared caplets of Linum and Ficus reduced the severity of constipation in patients.
Comparison of the In Vitro Antifibrogenic Effects of Silymarin, Silybin A and 18α-Glycyrrhizin on Activated Hepatic Stellate Cells
Authors: Amirghofran Zahra , Hosseini Seyed Younes , Kalantar Kurosh , Shahin Khashayar , Ghayour Maryam , Rajabi Bazl Masoumeh , Fattahi Mohammad-Reza , Moini Maryam
Published: December 2024

Background: Hepatic stellate cells (HSCs), the most important cells in liver fibrogenesis, are a major target of the fibrosis therapy. Objectives: This study aimed to compare the anti-fibrogenic effects of three natural components, including silymarin, silybin A and 18α-glycyrrhizin on an activated LX-2 HSC line under prophylactic and therapeutic conditions. Methods: We treated HSCs with silymarin, silybin A and 18α-glycyrrhizin before (prophylactic) and after (therapeutic) activation by TGF-β1, and then we measured their antiproliferative effects by the MTT assay. The level of released TGF-β1 was measured. Real-time polymerase chain reaction (PCR) analysis of the activated cells determined the gene expression levels of important fibrogenic-related molecules. Results: All components showed significant antiproliferative effects under the therapeutic condition (P < 0.01). Cell growth percentages inhibited by the 25 µg/mL concentrations of these products were 63.9 ± 4.7% (silymarin), 76.8 ± 1.6% (silybin A) and 86.8 ± 15.2% (18α-glycyrrhizin). In the prophylactic application, only silybin A had significant antiproliferative effects (85.1 ± 3.1%, P < 0.05). Silybin A had the highest reduction in TGF-β1 release in both conditions (P < 0.001). In real-time PCR, therapeutic treatment of cells with silybin A and 18α-glycirrhizin had greater impacts compared to silymarin in decreasing collagen type I-alpha-1 (COLIA1), tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinase (MMP)-2 mRNA levels. In contrast, under prophylactic conditions silymarin reduced all fibrogenic genes. Silybin A did not affect COLIA1 and 18α-glycyrrhizin had no effect on COLIA1 and TIMP-1. Conclusions: The antifibrogenic effects of silybin A and 18α-glycyrrhizin were stronger in the therapeutic compared to the prophylactic experiment. Silymarin had a greater inhibitory effect on fibrogenic gene expressions under the prophylactic condition.
The Laboratory and Clinical Factors Associated with Mortality in COVID-19 Patients
Authors: Izadi Amin , Darban Mahboubeh , Khanzadeh Germi Milad , Nabavi Sourena , Kouloubandi Mohammad Ali , Dadras Toussi Homa , Vaez Aysan , Ghazvini Malihe , Mirmohammadkhani Majid
Published: December 2024

Background: In December 2019, the Chinese government declared the occurrence of a new epidemic belonging to the coronavirus family; later, this epidemic was called COVID-19. Objectives: To determine the clinical and laboratory factors involved in the mortality of hospitalized COVID-19 patients. Methods: This descriptive-analytic study was performed in Kowsar Hospital of Semnan, Iran, using medical files of 107 patients hospitalized during February - April 2020 with COVID-19 diagnosis with the presence of chest CT findings. The patients' demographic information, vital signs, clinical symptoms, lab test results, the prescribed medicines during hospitalization, past medical history, and outcomes were analyzed. The relationship between each of the explanatory variables with death outcome was examined using univariate and multivariate logistic regression models, reporting crude and adjusted odds ratios (OR & Adj. OR). Results: The mean age of the patients was 63.36 ± 16.43 years, 67 (62.6%) patients were male, and 85 (79.4%) patients were discharged. Low level of consciousness (Glasgow coma scale < 14) (discharged: 8.2% vs. expired: 40.2%, Adj. OR [95% confidence interval] = 17.9 [3.1, 102.7]), higher body temperature (37.1°C vs. 37.74°C, 3.62 [1.55, 8.43]), and higher blood alkaline phosphatase (177.6 vs. 247.6, 1.01 [1.00, 1.01]) at the time of hospitalization were associated with increased mortality. Also, having the symptom of fatigue or weakness at the time of hospitalization (61.2 vs. 36.4%, 0.06 [0.01, 0.46]), higher red blood cells count (4.67 vs. 4.15, 0.21 [0.08, .55]), and higher blood oxygen saturation levels (89 vs. 82%, 0.92 [0.85, 0.99]) were associated with a lower risk of mortality. Conclusions: Decreased level of consciousness at the time of admission was shown to be a critical and independent predictor of mortality. Several factors are associated with death in patients with COVID-19, which due to the complexity of the relationship between each of them, it is not practical and plausible to make a definite prediction of patients' prognosis only by noting few factors without considering all the clinical symptoms and laboratory findings. The results of individual studies like ours should be interpreted alongside the results of previous and future clinical studies and not alone.
Modulatory Effects of Nano-Selenium Supplementation along with High Intensity Interval Training on Dexamethasone-Induced Liver Metaflammation
Authors: Hamedchaman Nader , Maleki Amir , Kahe Zahra , Hosseini Masoumeh , Delpisheh Ali
Published: December 2024

Background: Dexamethasone, a synthetic glucocorticoid, is widely used in clinical practice for various ailments. However, its use is associated with detrimental effects on the liver, including inflammation and oxidative stress. Selenium, an essential trace element, may serve as an effective ergogenic aid by enhancing anti-inflammatory and antioxidant properties, while high-intensity interval training (HIIT) has been shown to improve liver health. Objectives: The current study aimed to investigate the modulatory effects of selenium supplementation and HIIT on dexamethasone-induced liver inflammation in rats. Methods: Forty male Wistar rats (aged 6 - 8 weeks, 150 - 190 g) were randomly assigned to five groups (n = 8 per group): (1) Normal control (NC), (2) dexamethasone control (DC), (3) dexamethasone + high-intensity interval training + saline (DT), (4) dexamethasone + selenium supplement (DS), and (5) dexamethasone + selenium supplement + high-intensity interval training (DST). The training groups performed HIIT at a velocity of 24 - 34 m/min (~85% - 100% VO2max) for four weeks (5 days/week). Supplement groups received 100 mg of selenium (on odd days) via oral gavage. Inflammatory induction was achieved through subcutaneous injection of dexamethasone (0.4 mg/kg for 3 days). Gene expression levels of interleukin-4 (IL-4) and interleukin-5 (IL-1β) in liver tissue were determined using real-time PCR. Data were analyzed using one-way analysis of variance (ANOVA) and Bonferroni post hoc tests (P < 0.05). Results: Four weeks of dexamethasone supplementation significantly downregulated the inflammatory markers IL-4 (P = 0.077) and IL-1β (P = 0.029). Subsequently, HIIT and selenium supplementation were associated with significant modulation of IL-4 and IL-1β (P < 0.05). According to the Bonferroni results, HIIT combined with selenium supplementation had the greatest impact on the modulation of inflammatory markers in liver tissue. Conclusions: These findings suggest that selenium supplementation combined with HIIT can effectively improve inflammatory conditions in individuals suffering from liver metaflammation.
Objetivos del Desarrollo Sostenible en Educación y Aprendizaje. Universidades Públicas-Perú
Authors: Saavedra Villar Pablo , Mendoza Rejas Janet Natalia , Morales Alberto Manuel Nicolas , Saravia Domínguez Hurganda , Mendoza Rejas Amelia Rosa , Cabrera Morales Toti Germán
Published: December 2024

El estudio sobre los objetivos del Desarrollo Sostenible (ODS) y la mejora de la educación
universitaria; de cuatro instituciones públicas como son: Universidad Nacional de Huancavelica,
Universidad Nacional San Luis Gonzaga, Universidad Nacional de Cañete y Universidad Nacional
Federico Villarreal, Lima; con la intensión de establecer conexión general entre los ODS,
específicamente y los aspectos relacionados a la educación, enseñanza universitaria, evidenciando
su influencia en el desarrollo socio-educativo. El propósito es comprender y examinar cómo la
educación puede contribuir a la consecución de los objetivos de desarrollo sostenible establecidos
por la ONU, en particular aquellos que se vinculan con la mejora de la enseñanza universitaria en
un contexto turbio generado por el capitalismo y su incremento en el consumismo que afecta a la
humanidad y su ecosistema. Durante su desarrollo teórico y metodológico llevado a cabo en los
centros de instrucción universitario, convirtiéndose la ODS como herramienta que pueden
aplicarse en la enseñanza universitaria de una manera dinámica para lograr un impacto positivo
en la realidad social peruana. En consecuencia, la educación universitaria de acuerdo a lo
establecido por la ONU, se incorpora a una carrera que permita a los futuros líderes y
profesionales que contribuir de manera significativa al progreso social, económico y político a
favor de la mayoría. En consecuencia, resulta imperativo que se modifiquen los paradigmas
globalistas-capitalistas de la enseñanza universitaria por uno con un enfoque sostenible.
Pansitopenia as a Marker of Advanced Human Immunodeficiency Virus (HIV) infection: How Often? A Case Study Accompanied by Literature
Authors: Priyanto Muhammad Hikmawan , Faizun Muhammad
Published: December 2024

Pansitopenia is a condition characterized by anemia, thrombocytopenia, and leukopenia. One of the common etiologies of Pansitopenia is HIV infection. In advanced HIV, Pansitopenia may present even without other clinical findings leading to a diagnosis of HIV. This study was conducted as a case study of a 34-year-old man who presented with chief complaints of chronic diarrhea and fever that lasted for one month. Laboratory examination showed Pansitopenia, HIV-rapid reactive and peripheral blood picture indicating Pansitopenia/ aplastic anemia. Data were collected through history taking, physical examination, and a series of laboratory tests. The patient was diagnosed with Pansitopenia suspected to be caused by HIV infection. The chief complaints of chronic diarrhea and fever suggested a chronic disease process due to immune compromise, as seen in the patient's clinical status indicating advanced HIV. The literature suggests that the severity of pansitopenia depends on the severity of HIV disease. Pansitopenia can be an indicator of the advanced stage of HIV infection. Appropriate management and regular monitoring are essential to prevent further complications. Pansitopenia in HIV patients can be considered as an important indicator to assess the severity of the infection. Prompt treatment and antiretroviral therapy are highly recommended to improve the prognosis of patients.
Peduli Donor Darah dalam Memperingati Hari Kesehatan Nasional
Authors: Sudirman Sulaeman
Published: December 2024

Kebutuhan darah semakin meningkat seiring dengan meningkatnya penyakit tidak menular yang membutuhkan donor darah, sementara jumlah masyarakat yang mendonorkan darah di Indonesia masih rendah. Target WHO untuk kontribusi darah nasional sebesar 2 persen dari total penduduk belum tercapai. ITKES Muhammadiyah Sidrap sebagai institusi pendidikan berperan dalam meningkatkan ketersediaan suplai darah dari para pendonor. Tujuan kegiatan ini adalah meningkatkan ketersediaan suplai darah di mitra yaitu UTD RSUD Nene Mallomo Kabupaten Sidrap, yang merupakan RS yang lokasinya berdekatan dengan kampus ITKES. Metode yang digunakan adalah penggalangan pendonor dan pelaksanaan kegiatan donor darah bekerja sama dengan mitra. Peserta pendonor adalah pegawai dan mahasiswa ITKES Muhammadiyah Sidrap dengan target pendonor sebesar 100 orang. Kegiatan terlaksana pada tanggal 13 November 2024 di Kampus ITKES Muhammadiyah Sidrap. Diperoleh jumlah pendonor sebanyak 100 (100%) dari target.. Disimpulkan bahwa jumlah civitas ITKES Muhammadiyah Sidrap yang menjadi pendonor darah sangat antusias. Penting dilakukan komunikasi dan edukasi tentang pentingnya donor darah, serta kegiatan penggalangan berkala sangat efektif khususnya untuk pendonor pertama dan yang tidak rutin donor.
Pemberdayaan Ekonomi Masyarakat Pedesaan Melalui Pengembangan Jiwa Kewirausahaan Di Wilayah Pekanbaru
Authors: Indrayani Indrayani
Published: December 2024

Penelitian pengabdian masyarakat ini bertujuan menganalisis dan mengembangkan strategi pemberdayaan ekonomi di wilayah pedesaan Pekanbaru melalui pendekatan sistematis pembinaan kewirausahaan. Kegiatan difokuskan pada upaya mengatasi tantangan struktural seperti keterbatasan modal, rendahnya keterampilan usaha, dan minimnya motivasi ekonomi masyarakat. Melalui serangkaian intervensi berbasis partisipatif, penelitian ini berupaya mentransformasi potensi ekonomi lokal menjadi unit-unit usaha produktif.
Efforts to Improve Mental Health of the Elderly Through Healthy Elderly Gymnastics
Authors: Erik Adik Putra Bambang Kurniawan  , Enik Listyaningsih
Published: December 2024

Introduction: Elderly people are people with an age group at risk of experiencing mental health problems. In general, after people enter old age, they experience decreased memory and activity. With the decline in these two functions, the elderly also experience changes in psychosocial aspects related to the personality of the elderly. Given the large number of elderly people, it is necessary to have maintenance, especially mental health maintenance. Community-based mental health services as an effort to improve the quality of mental health services in the community by maximizing all the potential that exists in the community. Various activities for the elderly or elderly have been proven to help improve their health physically and mentally. Of the various types of activities for the elderly, gymnastics is one of the choices. Objective: To screen for mental health problems in the elderly: depression and to improve the mental health of the elderly through healthy elderly exercise. Design/method/approach: The method used is screening and physical activity intervention: Elderly Gymnastics. Findings/results: Based on the screening results, the majority of respondents did not experience depression with a total of 23 respondents (76.67%), mild depression 6 respondents (20%) and moderate depression 1 respondent (3.33%). Based on the results of the elderly gymnastics intervention, it was found that 30 respondents (100%) chose the answer that they were happy with the gymnastics activities that had been carried out. Conclusion: Physical activity intervention: elderly gymnastics can be an effort to improve the mental health of the elderly.
Inovasi Manajemen Peserta Didik : Strategi Peningkatan Efektivitas Pembelajaran di SMP Muhammadiyah 2 Taman
Authors: Junivan  , Akmalia Ramadhani Najwa , Aula Rahma Putri  , Muhammad Latif Fatkurrohman  , Ayu Wulandari
Published: December 2024

This study aims to analyze the Innovation of Student Management Strategies on the Effectiveness of Learning for Students of SMP Muhammadiyah 2 Taman with a focus on three main elements: Planning, Implementation, and Evaluation. The method used is a Qualitative study, namely an interview with the Deputy Head of Curriculum of SMP Muhammadiyah 2 Taman regarding the three main elements of the research focus. which then the data will be reduced and made relevant to the results of previous research through journals and books to create further understanding. The results obtained indicate that SMP Muhammadiyah 2 Taman has implemented an innovative learning system, namely developing discipline by accustoming students to be active in class and limiting the use of cellphones at school, and spiritual experience, namely obeying Islamic religious knowledge through reciting the Koran according to their abilities, with levels of tajwid, tilawah, the Koran, and memorization. And there is an istighfar treatment for students who violate the rules inside and outside of learning, they are asked to reflect on the mistakes they have made. Because this school is an Islamic school, teachers are required to help students understand the teachings of the Koran and Hadith. This innovation is given to prepare students for the future.
Analisis Sistem Pendidikan sebagai Sistem Terpadu dalam Meningkatkan Pembelajaran
Authors: Habsy Bakhrudin All , Harianto Ine Muro'afah , Danendra Naufal Daffa
Published: December 2024

Education is an integral part of human life, where every individual receives education from their parents after birth. Educating a child from an early age is part of early education provided by the family, which gradually extends to education within certain institutions and the broader community. Education is crucial for human life, serving as a conscious effort to humanize individuals. In the educational process, it is not solely the responsibility of schools; all elements must play an equal role in advancing education. All components must contribute (Ika Purwaningsih, 2022) (Abd Rahman BP S. a., 2022) and connect with each other in developing educational institutions or sustaining the educational process. A system is a complex unit of interconnected components working together to achieve optimal goals. The components that enable the educational process include educational objectives, students, education providers, parents, teachers/educators, community and religious leaders, the educational interaction between students and educators, and the content of education.
Transformasi Pembelajaran dengan Coding: Membekali Pendidik MI Manba’ul Huda dalam Meningkatkan Literasi Digital Siswa
Authors: Sulastri Asri , Anisa Ana , Ibrahim Tatang
Published: December 2024

In the era of globalization which is marked by rapid technological development, education has undergone a significant transformation so it is considered important to innovate learning with coding through the ScracthJr application which aims to increase digital literacy in students and the introduction of coding as a learning method at MI Manba'ul Huda. This study uses a qualitative descriptive approach, with data collection through observation and in-depth interviews with teachers, madrasah heads, and students' parents. The results of the study show that the application of coding not only improves students' digital skills but also stimulates critical and logical thinking skills. A total of 57.1% stated that this coding was appropriate to be applied in learning, but as many as 64.3% stated that this coding could improve digital literacy in students while 35.7% expressed doubts. This is because there are difficulties from educators to master the coding, but this is a demand for educators to have more innovative competencies.