bluuebunny/crossref_metadata_2025 huggingface dataset:
Mismatch Responses Evoked by Sound Pattern Violation in the Songbird Forebrain Suggest Common Auditory Processing With Human
Authors: Mori Chihiro , Okanoya Kazuo
Published: March 2022

Learning sound patterns in the natural auditory scene and detecting deviant patterns are adaptive behaviors that aid animals in predicting future events and behaving accordingly. Mismatch negativity (MMN) is a component of the event-related potential (ERP) that is reported in humans when they are exposed to unexpected or rare stimuli. MMN has been studied in several non-human animals using an oddball task by presenting deviant pure tones that were interspersed within a sequence of standard pure tones and comparing the neural responses. While accumulating evidence suggests the homology of non-human animal MMN-like responses (MMRs) and human MMN, it is still not clear whether the function and neural mechanisms of MMRs and MMN are comparable. The Java sparrow (Lonchura oryzivora) is a songbird that is a vocal learner, is highly social, and maintains communication with flock members using frequently repeated contact calls and song. We expect that the songbird is a potentially useful animal model that will broaden our understanding of the characterization of MMRs. Due to this, we chose this species to explore MMRs to the deviant sounds in the single sound oddball task using both pure tones and natural vocalizations. MMRs were measured in the caudomedial nidopallium (NCM), a higher-order auditory area. We recorded local field potentials under freely moving conditions. Significant differences were observed in the negative component between deviant and standard ERPs, both to pure tones and natural vocalizations in the oddball sequence. However, the subsequent experiments using the randomized standard sequence and regular pattern sequence suggest the possibility that MMR elicited in the oddball paradigm reflects the adaptation to a repeated standard sound but not the genuine deviance detection. Furthermore, we presented contact call triplet sequences and investigated MMR in the NCM in response to sound sequence order. We found a significant negative shift in response to a difference in sequence pattern. This demonstrates MMR elicited by violation of the pattern of the triplet sequence and the ability to extract sound sequence information in the songbird auditory forebrain. Our study sheds light on the electrophysiological properties of auditory sensory memory processing, expanding the scope of characterization of MMN-like responses beyond simple deviance detection, and provides a comparative perspective on syntax processing in human.
Increased Prostaglandin E2 in Brainstem Respiratory Centers Is Associated With Inhibition of Breathing Movements in Fetal Sheep Exposed to Progressive Systemic Inflammation
Authors: Stojanovska Vanesa , Atta John , Kelly Sharmony B. , Zahra Valerie A. , Matthews-Staindl Eva , Nitsos Ilias , Moxham Alison , Pham Yen , Hooper Stuart B. , Herlenius Eric , Galinsky Robert , Polglase Graeme R.
Published: March 2022

Background

Preterm newborns commonly experience apnoeas after birth and require respiratory stimulants and support. Antenatal inflammation is a common antecedent of preterm birth and inflammatory mediators, particularly prostaglandin E2 (PGE2), are associated with inhibition of vital brainstem respiratory centers. In this study, we tested the hypothesis that exposure to antenatal inflammation inhibits fetal breathing movements (FBMs) and increases inflammation and PGE2 levels in brainstem respiratory centers, cerebrospinal fluid (CSF) and blood plasma.

Methods

Chronically instrumented late preterm fetal sheep at 0.85 of gestation were randomly assigned to receive repeated intravenous saline (n = 8) or lipopolysaccharide (LPS) infusions (experimental day 1 = 300 ng, day 2 = 600 ng, day 3 = 1200 ng, n = 8). Fetal breathing movements were recorded throughout the experimental period. Sheep were euthanized 4 days after starting infusions for assessment of brainstem respiratory center histology.

Results

LPS infusions increased circulating and cerebrospinal fluid PGE2 levels, decreased arterial oxygen saturation, increased the partial pressure of carbon dioxide and lactate concentration, and decreased pH (p < 0.05 for all) compared to controls. LPS infusions caused transient reductions in the % of time fetuses spent breathing and the proportion of vigorous fetal breathing movements (P < 0.05 vs. control). LPS-exposure increased PGE2 expression in the RTN/pFRG (P < 0.05 vs. control) but not the pBÖTC (P < 0.07 vs. control) of the brainstem. No significant changes in gene expression were observed for PGE2 enzymes or caspase 3. LPS-exposure reduced the numbers of GFAP-immunoreactive astrocytes in the RTN/pFRG, NTS and XII of the brainstem (P < 0.05 vs. control for all) and increased microglial activation in the RTN/pFRG, preBÖTC, NTS, and XII brainstem respiratory centers (P < 0.05 vs. control for all).

Conclusion

Chronic LPS-exposure in late preterm fetal sheep increased PGE2 levels within the brainstem, CSF and plasma, and was associated with inhibition of FBMs, astrocyte loss and microglial activation within the brainstem respiratory centers. Further studies are needed to determine whether the inflammation-induced increase in PGE2 levels plays a key role in depressing respiratory drive in the perinatal period.
Impact of Climate Change and Rubber (Hevea brasiliensis) Plantation Expansion on Reference Evapotranspiration in Xishuangbanna, Southwest China
Authors: Ling Zhen , Shi Zhengtao , Gu Shixiang , Wang Tao , Zhu Weiwei , Feng Guojian
Published: March 2022

The expansion of rubber (Hevea brasiliensis) cultivation plantation over the past few decades has been significantly explosive in Xishuangbanna, southwest China. More and more evidences concerning the expansion of rubber plantations lead to the negative influence to local regional hydrology. It is vital to explore the impact of climate change and rubber (Hevea brasiliensis) plantation expansion on reference evapotranspiration (ET0) for the sustainable and efficient use of regional water resources. In this study, the spatiotemporal variation of ET0 as well as its relationship in rubber plantations area in Xishuangbanna from 1970–2017 were analyzed by using trend, correlation and contribution analysis. The results showed that the rubber plantation was 12,768 ha yr–1 from 1990 to 2017 in Xishuangbanna, and nearly 40.8% of new rubber plantations expanded above 900 m in altitude from 2000 to 2017. Sunshine duration and average relative humidity were the key meteorological factors that affect ET0 in Xishuangbanna, with the sensitivity coefficient of 0.51 and 0.35, respectively. The multiyear relative change of ET0 in Xishuangbanna was 9.18%, and the total contribution of major climate factors was 7.87% during 1970 and 2017. The average relative humidity in the plantation area decreases, which directly leads to the increase of ET0. The amount of ET0 change from 2000 to 2017 affected by climate change increased at 3.13 mm/10a, whereas it was 2.17 mm/10a affected by the expansion of rubber plantations by quantitative separation. ET0 was significantly affected by climate change but intensified by the expansion of rubber plantation.
Maize Seed Germination Under Low-Temperature Stress Impacts Seedling Growth Under Normal Temperature by Modulating Photosynthesis and Antioxidant Metabolism
Authors: Meng Aiju , Wen Daxing , Zhang Chunqing
Published: March 2022

Spring maize is usually subjected to low-temperature stress during seed germination, which retards seedling growth later even under a suitable temperature. However, the mechanism underlying maize seed germination under low-temperature stress impacting seedling growth is still ambiguous. In this study, we used one low-temperature sensitive maize (SM) and one low-temperature resistance maize (RM) to investigate the mechanism. The results showed that the SM line had higher malondialdehyde content and lower total antioxidant capacity (TAC) and germination percentage than the RM line under low-temperature stress, indicating the vulnerability of SM line to low-temperature stress. Further transcriptome analysis revealed that seed germination under low-temperature stress caused the down-regulation of photosynthesis-related gene ontology terms in two lines. Moreover, the SM line displayed down-regulation of ribosome and superoxide dismutase (SOD) related genes, whereas genes involved in SOD and vitamin B6 were up-regulated in the RM line. Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that photosynthesis and antioxidant metabolism-related pathways played essential roles in response to low-temperature stress during seed germination. The photosynthetic system displayed a higher degree of damage in the SM line. Both qRT-PCR and physiological characteristics experiments showed similar results with transcriptome data. Taken together, we propose a model for maize seed germination in response to low-temperature stress.
Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
Authors: Pei Tianlin , Yan Mengxiao , Huang Yanbo , Wei Yukun , Martin Cathie , Zhao Qing
Published: March 2022

Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family.
E-Learning Research Trends in Higher Education in Light of COVID-19: A Bibliometric Analysis
Authors: Brika Said Khalfa Mokhtar , Chergui Khalil , Algamdi Abdelmageed , Musa Adam Ahmed , Zouaghi Rabia
Published: March 2022

This paper provides a broad bibliometric overview of the important conceptual advances that have been published during COVID-19 within “e-learning in higher education.” E-learning as a concept has been widely used in the academic and professional communities and has been approved as an educational approach during COVID-19. This article starts with a literature review of e-learning. Diverse subjects have appeared on the topic of e-learning, which is indicative of the dynamic and multidisciplinary nature of the field. These include analyses of the most influential authors, of models and networks for bibliometric analysis, and progress towards the current research within the most critical areas. A bibliometric review analyzes data of 602 studies published (2020–2021) in the Web of Science (WoS) database to fully understand this field. The data were examined using VOSviewer, CiteSpace, and KnowledgeMatrix Plus to extract networks and bibliometric indicators about keywords, authors, organizations, and countries. The study concluded with several results within higher education. Many converging words or sub-fields of e-learning in higher education included distance learning, distance learning, interactive learning, online learning, virtual learning, computer-based learning, digital learning, and blended learning (hybrid learning). This research is mainly focused on pedagogical techniques, particularly e-learning and collaborative learning, but these are not the only trends developing in this area. The sub-fields of artificial intelligence, machine learning, and deep learning constitute new research directions for e-learning in light of COVID-19 and are suggestive of new approaches for further analysis.
Maternal Interaction With Infants Among Women at Elevated Risk for Postpartum Depression
Authors: Goodman Sherryl H. , Muzik Maria , Simeonova Diana I. , Kidd Sharon A. , Owen Margaret Tresch , Cooper Bruce , Kim Christine Y. , Rosenblum Katherine L. , Weiss Sandra J.
Published: March 2022

Ample research links mothers’ postpartum depression (PPD) to adverse interactions with their infants. However, most studies relied on general population samples, whereas a substantial number of women are at elevated depression risk. The purpose of this study was to describe mothers’ interactions with their 6- and 12-month-old infants among women at elevated risk, although with a range of symptom severity. We also identified higher-order factors that best characterized the interactions and tested longitudinal consistency of these factors from 6 to 12 months of infant age. We leveraged data from eight projects across the United States (n = 647), using standardized depression measures and an adaptation of the NICHD Mother-Infant Interaction Scales. Overall, these depression-vulnerable mothers showed high levels of sensitivity and positive regard and low levels of intrusiveness, detachment, and negative regard with their infants. Factor analyses of maternal behaviors identified two overarching factors—“positive engagement” and “negative intrusiveness” that were comparable at 6 and 12 months of infant age. Mothers’ ability to regulate depressed mood was a key behavior that defined “positive engagement” in factor loadings. An exceptionally strong loading of intrusiveness on the second factor suggested its central importance for women at elevated depression risk. Mothers with severe depressive symptoms had significantly more “negative intrusiveness” and less “positive engagement” with their 6-month-old infants than women with moderate or fewer depressive symptoms, suggesting a potential tipping point at which symptoms may interfere with the quality of care. Results provide the foundation for further research into predictors and moderators of women’s interactions with their infant among women at elevated risk for PPD. They also indicate a need for evidence-based interventions that can support more severely depressed women in providing optimal care.
The Effects of eGovernment Efficiency on Subjective Wellbeing
Authors: Fan Mingyue , Epadile Motswedi , Qalati Sikandar Ali , Qureshi Naveed Akhtar
Published: March 2022

Undoubtedly, the internet has become the most convenient and efficient communication and service delivery channel adopted by most government agencies, referred to as eGovernment. This study explores how eGovernment efficiency influences users’ subjective wellbeing (SWB), using trust as a covert stimulus with the capacity to alter individuals’ overt behavior (utilization). Covert and overt stimuli act as significant factors influencing the relationship between citizens and the online environment, moderated by socio-demographic characteristics. Using situation–organism–behavior–consequence theory, we propose a research model consisting of online environment eGovernment efficiency (the situation) influencing trust development (the organism), which in turn influences utilization (the behavior), generating an impact on an individuals’ SWB (the consequence). We followed the structural equation modeling (SEM) approach to analyze the data survey N = 300, using Amos statistical techniques. Results reveal that the correlation between eGovernment efficiency and trust is positive and strong, trust and utilization is positive and moderate, and the correlation between utilization and SWB is positive and very strong. Stepwise regression analysis reveals that the control variables affect the relationship between eGovernment efficiency and trust. In the regression model: the highest education level explained 36% of the variance (model 1); adding age increased the variance explained to 39% (in model 2), and adding internet use frequency increased the variance explained to 41% (model 3). This study develops theoretical concepts of eGovernment use and how it affects citizens by indicating the psychological and behavioral situations as antecedents and mediators influencing SWB. It also provides practical suggestions for improving systems to correlate users’ feelings and behavior patterns to motivate trusting behavior, positively impacting users’ SWB to benefit citizens effectively.
Self-Efficacy and Professional Identity Among Freshmen Nursing Students: A Latent Profile and Moderated Mediation Analysis
Authors: Mei Xiao Xiao , Wang Hui Yuan , Wu Xiao Na , Wu Jie Yi , Lu Ying Zi , Ye Zeng Jie
Published: March 2022

This study was designed to estimate the associations between self-efficacy and professional identity. A total of 1,051 freshmen nursing students (FNSs) from the Be Resilient to Nursing Career (BRNC) program were recruited from four universities between September and November 2020. A latent profile and moderated meditation analysis were performed. Four profiles of self-efficacy were identified and named as Lowest (15.6%), Med-low (45.0%), Med-high (32.7%), and Highest (6.7%). The mediating role of resilience and the moderating effect of role models were also identified. Therefore, self-efficacy, resilience, and role models may be three important factors to professional identity in FNSs and these relationships should be further validated in longitudinal or interventional studies.
Fickle Judgments in Moral Dilemmas: Time Pressure and Utilitarian Judgments in an Interdependent Culture
Authors: Hashimoto Hirofumi , Maeda Kaede , Matsumura Kaede
Published: March 2022

In the trolley problem, a well-known moral dilemma, the intuitive process is believed to increase deontological judgments, while deliberative reasoning is thought to promote utilitarian decisions. Therefore, based on the dual-process model, there seems to be an attempt to save several lives at the expense of a few others in a deliberative manner. This study examines the validity of this argument. To this end, we manipulate decision-making time in the standard trolley dilemma to compare differences among 119 Japanese female undergraduates under three conditions: intuitive judgment, deliberative judgment, and judgment after a group discussion. The current results demonstrate that utilitarian judgments decreased from 52.9% in the intuition condition to 43.7% in the deliberation condition and 37.0% after the discussion. Additional analysis suggests that the decrease in utilitarian judgments may be related to psychological unwillingness to assume responsibility for the lives of others rather than to an increase in deontological judgments. Finally, these results are discussed from an adaptationist perspective.
Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network
Authors: Banihashemi Layla , Peng Christine W. , Rangarajan Anusha , Karim Helmet T. , Wallace Meredith L. , Sibbach Brandon M. , Singh Jaspreet , Stinley Mark M. , Germain Anne , Aizenstein Howard J.
Published: March 2022

Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology.
Will They Stay or Will They Go? Motivational Profiles, Retirement-Related Correlates, and Retirement Intentions Among 58–72-Year-Old Workers
Authors: Halvari Hallgeir , Olafsen Anja H.
Published: March 2022

Demographic changes indicate that the number of people aged 60 years and above will double in the next 30 years, and politicians around the world have an interest in delaying retirement in order to benefit national economies by lowering the burden on public pension systems. In this study, it is examined whether and how combinations of multiple types of work motivation based on self-determination theory (SDT) would be associated with retirement-related factors and retirement intentions. Using a person-centered approach to identify latent work motivation profiles among older workers, four profiles emerged: (1) the Low Motivation Profile with below-average levels on most motivational regulations, but in particular, lack identified work regulation; (2) the Autonomous Motivation Profile with higher levels of autonomous motivation and lower levels of controlled motivation and amotivation; (3) the High Motivation Profile with simultaneously high autonomous and controlled motivation; (4) the Amotivated Profile. Compared to the Low Motivation and Amotivated Profiles, the Autonomous and the High Motivation profiles show higher levels of vigor and lower levels of job stress, exhaustion and turnover-, and retirement intentions. However, the High Motivation Profile seems to pay a cost because they experience significantly more job stress than employees in the Autonomous profile. In addition, variable-based correlations showed higher levels of vigor and lower levels of job stress, exhaustion, and turnover intentions to be associated with lower levels of retirement intentions. The results are discussed in relation to managers and organizational endeavors to rebuild lost work identification and reduce extrinsic work motivation and amotivation in order to motivate older workers to stay longer at work.
Mediating Effect of Filial Piety Between the Elderly’s Family Resource Contribution and Their Family Power: Evidence from China
Authors: Liu Xin , Bai Shuying
Published: March 2022

With the development of rationalism, although the concept of filial piety is still an important factor affecting family relations, its rules have changed. Based on the resource theory and by measuring family power via the role played in family decision-making (FDM), this study explored the mediating role of filial piety norms between elderly’s family resource contributions and family power in intergenerational cohabitation families in Mengzhou city, China. Using a stratified sampling method, 1,200 elderly people were recruited for data collection. Multiple linear regression analysis was used for testing. The results show that (1) the elderly still have some FDM in Chinese intergenerational cohabitation families, and the family power of elderly men is still higher than that of elderly women, which indicate that the influence of traditional patriarchal norms still exists in the family. (2) Filial piety culture mediates between the elderly’s relative economic income (relative to their adult children) and their family power and also mediates the relationship of the elderly’s relative educational level (relative to their adult children) and their family power. It shows that the resources of the elderly relative to their children affect the filial piety of their adult children and then affect the FDM of the elderly. The study is theoretically and practically meaningful.
Using Unified Theory of Acceptance and Use of Technology to Evaluate the Impact of a Mobile Payment App on the Shopping Intention and Usage Behavior of Middle-Aged Customers
Authors: Liu Che-Hung , Chen Yen-Tzu , Kittikowit Santhaya , Hongsuchon Tanaporn , Chen Yi-Jing
Published: March 2022

This research adopted the unified theory of acceptance and use of technology (UTAUT) to emphasize the use of the PX Pay mobile payment app for PX Mart, the most popular supermarket in Taiwan, and examine the degree of involvement as a moderator. The influence of factors related to PX Mart’s target customer groups on their shopping intentions and usage behaviors were discussed, with subsequent benefits and optimization directions. This study indicated the following results. First, performance expectations, ease-of-use expectations, and social impact enhance consumers’ behavioral intention and behavioral intention significantly influence usage behavior. Second, gender has no significant moderating effect on the proposed model. Third, age has a moderating effect from performance expectations and ease-of-use expectations, social influence on behavioral intention. Fourth, use is more significantly affected by perceived stakeholders for customers over age 50 than for those age 30–39. Fifth, the degree of involvement significantly affects the relationship between behavioral intention and usage behavior in terms of social influence and facilitating conditions effects. Finally, we provided academic and practical implications and make contributions to both the online payment industry and academia.
Social Facilitation in Fear Appeals Creates Positive Affect but Inhibits Healthy Eating Intentions
Authors: Bailey Rachel L. , Wang Tianjiao Grace , Liu Jiawei , Clayton Russell B. , Kwon Kyeongwon , Diwanji Vaibhav , Karimkhanashtiyani Farzaneh
Published: March 2022

The social facilitation of eating plays a significant role in influencing individuals’ eating decisions. However, how social eating cues are processed in health promotion messages is unclear. This study examined individuals’ food craving in response to social cues in images (Experiment 1) and emotional experiences, perceived threat, perceived efficacy, behavioral intentions, and motivational coactivation elicited by social eating cues in obesity prevention fear appeals (Experiment 2). Results suggested that the presence of a group of people eating in an image facilitated food craving for the presented foods. Moreover, fear appeals that presented obesity and its consequences with more social eating cues, versus individual eating cues, generated greater positive emotional responses, perceived threat severity, response and self-efficacy, and motivational coactivation indicating more attention and threat vigilance. However, these cues also generated fewer self-reported intentions to change unhealthy eating behaviors. Implications and suggestions for future research are discussed.
Research on the Construction of a Comprehensive Evaluation Model of Psychological Factors in Coal Mine Workers' Safety: Investigation and Analysis of 1,500 Miners in East China
Authors: Zhu Junqi , Wang Xue , Yang Li , Qin Zhiyuan , Geng Jichao , Zhang Xuesen
Published: March 2022

With China's economic and social development entering a new era, the improvement of miners' living standards and safety production conditions in coal mine are bound to have a new impact on the safety needs of miners. In order to explore the structural changes of miners' safety demands in the new era, this research adopts the second-order confirmatory factor analysis method to investigate miners from six coal mining enterprises based on Koffka's cognitive psychology theory. Firstly, according to the interaction between the behavioral environment and the self-regulation of coal miners, six potential variables affecting miners' safety psychology, such as material satisfaction, non-skill internal causes, professionalism, emotional attribution, safety atmosphere, and organizational management, are selected. Then, each potential variable is subdivided into 3 observation variables, for a total of 18 observation variables, and a 3-tier comprehensive structural model of miners' safety psychology is constructed that takes into account both evaluation and path integration. The results showed that, affected by the interaction of various potential variables, the degree and intensity of the influence of each factor on miners' safety psychology were different. Among them, emotional attribution was the most significant factor affecting miners' safety psychology, while the influence of organizational management was slightly less important than emotional attribution. Organizational management had a positive impact on material satisfaction and non-skill internal factors. Occupational literacy, material satisfaction, and safety atmosphere had strong impacts on miners' safety psychology. But the impact of non-skill factors on miners' safety psychology was lower than other factors, which is different to previous studies on this aspect.
Early-Stage Alzheimer's Disease Prediction Using Machine Learning Models
Authors: Kavitha C. , Mani Vinodhini , Srividhya S. R. , Khalaf Osamah Ibrahim , Tavera Romero Carlos Andrés
Published: March 2022

Alzheimer's disease (AD) is the leading cause of dementia in older adults. There is currently a lot of interest in applying machine learning to find out metabolic diseases like Alzheimer's and Diabetes that affect a large population of people around the world. Their incidence rates are increasing at an alarming rate every year. In Alzheimer's disease, the brain is affected by neurodegenerative changes. As our aging population increases, more and more individuals, their families, and healthcare will experience diseases that affect memory and functioning. These effects will be profound on the social, financial, and economic fronts. In its early stages, Alzheimer's disease is hard to predict. A treatment given at an early stage of AD is more effective, and it causes fewer minor damage than a treatment done at a later stage. Several techniques such as Decision Tree, Random Forest, Support Vector Machine, Gradient Boosting, and Voting classifiers have been employed to identify the best parameters for Alzheimer's disease prediction. Predictions of Alzheimer's disease are based on Open Access Series of Imaging Studies (OASIS) data, and performance is measured with parameters like Precision, Recall, Accuracy, and F1-score for ML models. The proposed classification scheme can be used by clinicians to make diagnoses of these diseases. It is highly beneficial to lower annual mortality rates of Alzheimer's disease in early diagnosis with these ML algorithms. The proposed work shows better results with the best validation average accuracy of 83% on the test data of AD. This test accuracy score is significantly higher in comparison with existing works.
Morphology in a Parallel, Distributed, Interactive Architecture of Language Production
Authors: Kapatsinski Vsevolod
Published: March 2022

How do speakers produce novel words? This programmatic paper synthesizes research in linguistics and neuroscience to argue for a parallel distributed architecture of the language system, in which distributed semantic representations activate competing form chunks in parallel. This process accounts for both the synchronic phenomenon of paradigm uniformity and the diachronic process of paradigm leveling; i.e., the shaping or reshaping of relatively infrequent forms by semantically-related forms of higher frequency. However, it also raises the question of how leveling is avoided. A negative feedback cycle is argued to be responsible. The negative feedback cycle suppresses activated form chunks with unintended semantics or connotations and allows the speaker to decide when to begin speaking. The negative feedback cycle explains away much of the evidence for paradigmatic mappings, allowing more of the grammar to be described with only direct form-meaning mappings/constructions. However, there remains an important residue of cases for which paradigmatic mappings are necessary. I show that these cases can be accounted for by spreading activation down paradigmatic associations as the source of the activation is being inhibited by negative feedback. The negative feedback cycle provides a mechanistic explanation for several phenomena in language change that have so far eluded usage-based accounts. In particular, it provides a mechanism for degrammaticalization and affix liberation (e.g., the detachment of-holicfrom the context(s) in which it occurs), explaining how chunks can gain productivity despite occurring in a single fixed context. It also provides a novel perspective on paradigm gaps. Directions for future work are outlined.
Exodex Adam—A Reconfigurable Dexterous Haptic User Interface for the Whole Hand
Authors: Lii Neal Y. , Pereira Aaron , Dietl Julian , Stillfried Georg , Schmidt Annika , Beik-Mohammadi Hadi , Baker Thomas , Maier Annika , Pleintinger Benedikt , Chen Zhaopeng , Elawad Amal , Mentzer Lauren , Pineault Austin , Reisich Philipp , Albu-Schäffer Alin
Published: March 2022

Applications for dexterous robot teleoperation and immersive virtual reality are growing. Haptic user input devices need to allow the user to intuitively command and seamlessly “feel” the environment they work in, whether virtual or a remote site through an avatar. We introduce the DLR Exodex Adam, a reconfigurable, dexterous, whole-hand haptic input device. The device comprises multiple modular, three degrees of freedom (3-DOF) robotic fingers, whose placement on the device can be adjusted to optimize manipulability for different user hand sizes. Additionally, the device is mounted on a 7-DOF robot arm to increase the user’s workspace. Exodex Adam uses a front-facing interface, with robotic fingers coupled to two of the user’s fingertips, the thumb, and two points on the palm. Including the palm, as opposed to only the fingertips as is common in existing devices, enables accurate tracking of the whole hand without additional sensors such as a data glove or motion capture. By providing “whole-hand” interaction with omnidirectional force-feedback at the attachment points, we enable the user to experience the environment with the complete hand instead of only the fingertips, thus realizing deeper immersion. Interaction using Exodex Adam can range from palpation of objects and surfaces to manipulation using both power and precision grasps, all while receiving haptic feedback. This article details the concept and design of the Exodex Adam, as well as use cases where it is deployed with different command modalities. These include mixed-media interaction in a virtual environment, gesture-based telemanipulation, and robotic hand–arm teleoperation using adaptive model-mediated teleoperation. Finally, we share the insights gained during our development process and use case deployments.
Robot-Mediated Inclusive Processes in Groups of Children: From Gaze Aversion to Mutual Smiling Gaze
Authors: Tuncer Sylvaine , Gillet Sarah , Leite Iolanda
Published: March 2022

Our work is motivated by the idea that social robots can help inclusive processes in groups of children, focusing on the case of children who have newly arrived from a foreign country and their peers at school. Building on an initial study where we tested different robot behaviours and recorded children’s interactions mediated by a robot in a game, we present in this paper the findings from a subsequent analysis of the same video data drawing from ethnomethodology and conversation analysis. We describe how this approach differs from predominantly quantitative video analysis in HRI; how mutual gaze appeared as a challenging interactional accomplishment between unacquainted children, and why we focused on this phenomenon. We identify two situations and trajectories in which children make eye contact: asking for or giving instructions, and sharing an emotional reaction. Based on detailed analyses of a selection of extracts in the empirical section, we describe patterns and discuss the links between the different situations and trajectories, and relationship building. Our findings inform HRI and robot design by identifying complex interactional accomplishments between two children, as well as group dynamics which support these interactions. We argue that social robots should be able to perceive such phenomena in order to better support inclusion of outgroup children. Lastly, by explaining how we combined approaches and showing how they build on each other, we also hope to demonstrate the value of interdisciplinary research, and encourage it.
Waste Management and Circular Economy in the French Building and Construction Sector
Authors: Diemer Arnaud , Nedelciu Claudiu Eduard , Morales Manuel E. , Batisse Cécile , Cantuarias-Villessuzanne Carmen
Published: March 2022

The impact that European and French legislation have on the circular economy implementation between market-driven incentives and state regulation emerges as the main challenge addressed in this chapter. Circular economy principles and the normative aspects of legislation constitute the best available frameworks to foresee how circular economy implementation will evolve in the building and construction sector in France. The Eiffage case study can be explained by the evolution of the normative arena composed by the current codes, environmental laws, roadmaps, and directives that frame the dynamic behavior of individual actors submitted to market pressures. A literature review of the current scientific and gray literature on circular economy in the building and construction sector was carried out in order to identify the required conditions to improve circularity in a normative way in France. Seven circular economy principles have been identified in the state of the art of Building and construction sector in France with emphasis on four of them: (1) Building lighter structures, (2) Waste reduction in the production process, (3) Intensive use of floor space, and (4) Extension of product life or recycling. Finally, we claim that the advantage of the normative approach implementation and analysis is to set the social agreement of compulsory foundation over which the market-driven initiatives and innovation could make the difference for the outstanding stakeholders of the economic sector.
Towards an Integrated Approach to Improve the Understanding of the Relationships Between Water-Borne Infections and Health Outcomes: Using Malaysia as a Detailed Case Study
Authors: Ho Jia Yee , Lavinya Amanda Anne , Kay Dominic Shuen Wei , Lee Cindy Ik Sing , Razmi Ahmad Haikal , Walsh Claire L. , Goodson Michaela L. , Eswaran Jeyanthy
Published: March 2022

As in many low- and middle-income countries around the world, thousands of local communities in Southeast Asia rely on river water to sustain their livelihoods. However, poor water quality threatens the health of both humans and ecosystems. The aim of this review was to examine the available literature to investigate how health outcomes in Malaysia have been studied and reported as directly attributable to human infections from river water. Computer-aided searches from 10 electronic databases were undertaken, with searches limited to the English language and publication dates since January 2010. The literature search revealed that the predominant river water infections identified in Malaysia were bacterial (coliforms,Salmonellaspp., typhoid, leptospirosis, melioidosis), viral (including dengue, hepatitis, enterovirus), parasitic infections including amoebiasis, giardiasis and cryptosporidiosis, helminth infections,Blastocystisinfections and sarcocystosis. No studies were found that have attempted to evaluate the impact of water related infection on human health longitudinally. Moreover, the possibility of integrated water governance systems that could reduce infection and improve water quality, particularly for marginalized groups have not been discussed or studied. Several cross-sectional studies identified infections at a point in time, but large longitudinal data sets of water infection parameters and how they influence human health outcomes have not been reported. Using Malaysia as a demonstration case study, we suggest a number of recommendations based on using a systems approach to tackle the challenges involved in data collection and integration, which is central to the understanding, strategic planning and management of water-borne infections.
Eicosanoid Biosynthesis in Male Reproductive Development: Effects of Perinatal Exposure to NSAIDs and Analgesic Drugs
Authors: Tran-Guzman Amy , Culty Martine
Published: March 2022

Increasing rates of infertility associated with declining sperm counts and quality, as well as increasing rates of testicular cancer are contemporary issues in the United States and abroad. These conditions are part of the Testicular Dysgenesis Syndrome, which includes a variety of male reproductive disorders hypothesized to share a common origin based on disrupted testicular development during fetal and neonatal stages of life. Male reproductive development is a highly regulated and complex process that relies on an intricate coordination between germ, Leydig, and Sertoli cells as well as other supporting cell types, to ensure proper spermatogenesis, testicular immune privilege, and endocrine function. The eicosanoid system has been reported to be involved in the regulation of fetal and neonatal germ cell development as well as overall testicular homeostasis. Moreover, non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics with abilities to block eicosanoid synthesis by targeting either or both isoforms of cyclooxygenase enzymes, have been found to adversely affect male reproductive development. This review will explore the current body of knowledge on the involvement of the eicosanoid system in male reproductive development, as well as discuss adverse effects of NSAIDs and analgesic drugs administered perinatally, focusing on toxicities reported in the testis and on major testicular cell types. Rodent and epidemiological studies will be corroborated by findings in invertebrate models for a comprehensive report of the state of the field, and to add to our understanding of the potential long-term effects of NSAID and analgesic drug administration in infants.
The Effects of a Morphed Trailing-Edge Flap on the Aeroacoustic and Aerodynamic Performance of a 30P30N Aerofoil
Authors: Watkins Joseph , Bouferrouk Abdessalem
Published: March 2022

This paper presents initial results on the aeroacoustic and aerodynamic effects of morphing the trailing-edge flap of the 30P30N aerofoil, over five flap deflections (5–25°), at an 8° angle of attack and a Reynolds number of Re=9.2×105. The Ffowcs-Williams–Hawkings acoustic analogy estimates the far-field noise, whilst the flow field is solved using URANS with the four-equation Transition SST model. Aerodynamic and aeroacoustic simulation data for the 30P30N’s full configuration compare well with experimental results. A Courant number (C) ≤ 1 should be used for resolving tonal noise, whilst a C of up to 4 is sufficient for broadband noise. Sound pressure level results show an average 11% reduction in broadband noise across all flap deflections and frequencies for the morphed configuration compared with the conventional, single-slotted flap. The morphed flap eliminates the multiple tonal peaks observed in the conventional design. Beyond 15° flap deflection, the morphing flap achieves higher stall angles, but with increased drag, leading to a maximum reduction of 17% in Cl/Cd ratio compared with the conventional flap. The methodology reported here for the 30P30N is a quick tool for initial estimates of the far-field noise and aerodynamic performance of a morphing flap at the design stage.
Evaluation of Ground-Based Models for Estimating Surface Albedo with In-Situ Radiometric Measurements across China
Authors: Chen Gang , Zhou Mi , Gu Shixiang , Chen Jinming , Wu Lei
Published: March 2022

Surface albedo is an essential parameter in many solar radiation applications. Although several models are available, it remains debatable whether they are applicable to other locations. Using long-term daily measurements of radiation acquired by observational networks in China, this study examined the applicability of six existing albedo models: Ineichen model (IeM), Gueymard model (GM), Dong model (DeM), Iziomon-Mayer model (IMM), Morton model (MM), and Zhou model (ZeM). The evaluation results of model performance through statistical analysis showed that among the available ground albedo models, ZeM had the best overall performance at 12 selected stations, IeM was shown to provide acceptable estimations for locations where albedo records are readily available. The statistical results of individual station have shownthat the number of input parameters is not the only key factor for determining the predictive performance of ground albedo models. In other words, a simple model has potential for accurate estimation of ground albedo with appropriate model parameters. Therefore, the simple two-parameter DeM was selected to re-calibrate with in-situ radiometric measurements, which can be adopted as a surrogate for ZeM to predict surface albedo in China.
Cognitive and Physical Intervention in Metals’ Dysfunction and Neurodegeneration
Authors: Jopowicz Anna , Wiśniowska Justyna , Tarnacka Beata
Published: March 2022

Metals—especially iron, copper and manganese—are important elements of brain functions and development. Metal-dysregulation homeostasis is associated with brain-structure damage to the motor, cognitive and emotional systems, and leads to neurodegenerative processes. There is more and more evidence that specialized cognitive and motor exercises can enhance brain function and attenuate neurodegeneration in mechanisms, such as improving neuroplasticity by altering the synaptic structure and function in many brain regions. Psychological and physical methods of rehabilitation are now becoming increasingly important, as pharmacological treatments for movement, cognitive and emotional symptoms are limited. The present study describes physical and cognitive rehabilitation methods of patients associated with metal-induced neurotoxicity such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and Wilson’s disease. In our review, we describe physical (e.g., virtual-reality environments, robotic-assists training) and psychological (cognitive training, cognitive stimulation, neuropsychological rehabilitation and cognitive-behavioral and mindfulness-based therapies) methods, significantly improving the quality of life and independence of patients associated with storage diseases. Storage diseases are a diverse group of hereditary metabolic defects characterized by the abnormal cumulation of storage material in cells. This topic is being addressed due to the fact that rehabilitation plays a vital role in the treatment of neurodegenerative diseases. Unfortunately so far there are no specific guidelines concerning physiotherapy in neurodegenerative disorders, especially in regards to duration of exercise, type of exercise and intensity, as well as frequency of exercise. This is in part due to the variety of symptoms of these diseases and the various levels of disease progression. This further proves the need for more research to be carried out on the role of exercise in neurodegenerative disorder treatment.