bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-metric geometry as the origin of mass in gauge theories of scale invariance
Authors: Ghilencea D. M.
Published: February 2023

We discuss gauge theories of scale invariance beyond the Standard Model (SM) and Einstein gravity. A consequence of gauging this symmetry is that their underlying 4D geometry is non-metric ($$\nabla _\mu g_{\alpha \beta }\!\not =\!0$$

∇
μ

g

α
β

≠

0

). Examples of such theories are Weyl’s original quadratic gravity theory and its Palatini version. These theories have spontaneous breaking of the gauged scale symmetry to Einstein gravity. All mass scales have a geometric origin: the Planck scale ($$M_p$$

M
p

), cosmological constant ($$\Lambda $$
Λ
) and the mass of the Weyl gauge boson ($$\omega _\mu $$

ω
μ

) of scale symmetry are proportional to a scalar field vev that has an origin in the (geometric) $${\tilde{R}}^2$$

R
~

2

term in the action. With $$\omega _\mu $$

ω
μ

of non-metric geometry origin, the SM Higgs field also has a similar origin, generated by Weyl boson fusion in the early Universe. This appears as a microscopic realisation of “matter creation from geometry” discussed in the thermodynamics of open systems applied to cosmology. Unlike in local scale invariant theories (with no $$\omega _\mu $$

ω
μ

present) with an underlying pseudo-Riemannian geometry, in our case: (1) there are no ghosts and no additional fields beyond the SM and underlying Weyl or Palatini geometry, (2) the cosmological constant is positive and is small because gravity is weak, (3) the Weyl or Palatini connection shares the Weyl (gauge) symmetry of the action, and: (4) there exists a non-trivial, conserved Weyl current of this symmetry. An intuitive picture of non-metricity and its relation to mass generation is also provided from a solid state physics perspective where it is common and is associated with point defects (metric anomalies) of the crystalline structure.
Black hole thermodynamics from logotropic fluids
Authors: Capozziello Salvatore , D’Agostino Rocco , Lapponi Alessio , Luongo Orlando
Published: February 2023

We show that the Einstein field equations with a negative cosmological constant can admit black hole solutions whose thermodynamics coincides with that of logotropic fluids, recently investigated to heal some cosmological and astrophysical issues. For this purpose, we adopt the Anton–Schmidt equation of state, which represents a generalized version of logotropic fluids. We thus propose a general treatment to obtain an asymptotic anti-de Sitter metric, reproducing the thermodynamic properties of both Anton–Schmidt and logotropic fluids. Hence, we explore how to construct suitable spacetime functions, invoking an event horizon and fulfilling the null, weak, strong and dominant energy conditions. We further relax the strong energy condition to search for possible additional solutions. Finally, we discuss the optical properties related to a specific class of metrics and show how to construct an effective refractive index depending on the spacetime functions and the thermodynamic quantities of the fluid under study. We also explore possible departures with respect to the case without the fluid.
Effect of doping gas on HFCVD diamond thin films deposited on cemented carbide substrates
Authors: Park Jin Hyeok , Jang Tae Hwan , Kim Tae Gyu , Bae Mun Ki
Published: February 2023

Herein, coating diamonds on WC–Co by using the hot filament chemical vapor deposition (HFCVD) method are discussed. CVD was performed for 8 h under a deposition pressure of 40 torr using various doping gases such as boron, nitrogen, and argon to control the particle size of the diamond thin films, the surface was then analyzed through scanning electron microscopy (SEM) and Raman spectroscopy. The SEM images confirmed that the diamond crystal size was reduced upon boron and argon doping. In contrast, nitrogen doping promoted the growth of diamond crystals. In the Raman spectra, the D and G bands were observed at 1332 and 1580 cm[Formula: see text], respectively. Thus, the surface roughness can be controlled using a variety of doping gases, which may be used in tools.
Electron bunch acceleration by an azimuthally polarized laser pulse in the presence of a helical wiggler and external magnetic field
Authors: Asri Mehdi , Mehdipoor Mostafa
Published: February 2023

This study investigates the acceleration of a single electron and an electron bunch by an azimuthally polarized (AP) laser pulse in the presence of a helical wiggler and external magnetic field in the form of a hyperbolic tangent (HT) function. The wiggler parameters were optimized to retain betatron resonance for a long time, as a result of which it was found that the optimum values of HT magnetic field strength and its parameter increase the interaction length. The laser fields, the wiggler magnetic field, and the HT magnetic field cooperatively helped cause the generation of the high energetic electrons. Finally, highly energetic electrons were obtained with a mean energy of about 2 GeV and an extremely low mean scattering angle of [Formula: see text], and an acceleration gradient of about 42 GeV/m.
The role of crustal-scale shear zones in SW Gondwana consolidation – transatlantic correlation
Authors: Schmitt Renata da S. , Trouw Rudolph A. J. , Alves da Silva Evânia , de Jesus João Vitor Mendes , da Costa Luis Felipe M. , Passarelli Claudia R.
Published: February 2023

We present the first correlation between South American and African shear zones based on a reconstruction model of SW Gondwana continental crust, correlating 57 Brasiliano–Pan-African crustal-scale shear zones that sutured this palaeocontinent at
c.
500 Ma. The final amalgamation and consolidation of the SW Gondwana continental crust were attained by an anticlockwise rotation of three cratons (Kalahari, Angola and São Francisco) in relation to the clockwise rotation of the Río de la Plata Craton in the Early Paleozoic. These relative movements were accommodated by transcurrent shear zones active from 585 to 500 Ma within the Pan-African–Brasiliano belts that surround these cratons. This kinematic interaction resulted in the initiation of a long-term active margin starting with the Cambrian Pampean orogeny and ending with the Permian–Triassic Gondwanide orogeny.
Historically Informed HCI: Reflecting on Contemporary Technology through Anachronistic Fiction
Authors: Mensonge Kien
Published: February 2023

As computing technology comes to dominate every aspect of social and political life, HCI must take greater account of History. The article considers four different historical periods impacted by division and denunciation: the European Witch Hunts, the Soviet Purges, the McCarthy Era, and the Chinese Cultural Revolution. Historians have identified patterns common to such periods including: the unity of accusation and action; condemnation as a show of virtue, and defense of the accused as collusion with enemies. These patterns are mapped to findings from social media research such as: impulsive shares are easy to make but difficult to retract; angry posts travel fastest and furthest; likes and retweets express group identity and solidarity. Anachronistic memes, tweets and selfies explore what previous eras might have looked like if contemporary technology had existed in the past. It is argued that such anachronistic fiction may be a useful method for exploring the potential impact of particular design choices.
Reinforcement Learning-Based Intelligent Task Scheduling for Large-Scale IoT Systems
Authors: Jin Chenghou , Han Yusen , Deng Zhuo , Chen Ying , Liu Chengxia , Huang Jiwei
Published: February 2023

The new-generation of Internet of Things (NG-IoT) brings a wide range of challenging problems. At the same time, cloud computing technology is an important foundation for the development of the IoT. In this article, we focus on the task scheduling problem in IoT systems in cloud computing environment. Our goal is to minimize the task runtime. It is well known that the problem of the task scheduling has been a challenging problem. In the last decade, despite being theoretically hard problem, researchers design lots of state-of-the-art algorithms for solving this problem. In our work, we propose a novel efficient reinforcement learning (RL) algorithm to solve the task scheduling problem in IoT systems (EATS), which combines combinatorial optimization to make our proposed algorithm have stable lower bounds. We process a batch of tasks at a time, make decisions on task selection through reinforcement learning, and solve them further through combinatorial optimization methods. The results of the experiments show that our proposed algorithm has outstanding performance in different environments.
[Retracted] Association between Elderly Sarcopenia and Inflammatory Cytokine Interleukin‐17: A Cross‐Sectional Study
Authors: Xiong Lu , Chen Ying , Dong Xiao , Li Yunqian , Zeng Min , Liu Kai
Published: February 2023

Aging slows down the mechanisms behind skeletal muscle weakening and mobility. Increases in inflammation brought on by aging may contribute to some characteristics of sarcopenia. As a result of population aging worldwide, sarcopenia, an age‐related disease, has become a huge burden on both individuals and society as a whole. The study of the morbidity mechanism and available sarcopenia treatments has received more attention. The inflammatory response may be one of the most important methods behind the pathophysiology of sarcopenia in the aged, according to the background of the study. This anti‐inflammatory cytokine inhibits the ability of human monocytes and macrophages to induce inflammation as well as the production of cytokines like IL‐6. Here, we investigate the association between sarcopenia and interleukin‐17 (IL‐17), an inflammatory cytokine in the aged. There were 262 subjects aged 61‐90 years who were screened for sarcopenia in Hainan General Hospital. The subjects were divided into 45 males and 60 females aged 65‐79 years (average age: 72.00 ± 4.31 years). 105 patients without sarcopenia were randomly selected among 157 participants. It included 50 males and 55 females, aged 61‐76 years (mean age: 69.10 ± 4.55 years) as per the standard definition of the Asian Working Group for Sarcopenia (AWGS). The “skeletal muscle index” (SMI), “hand grip strength” (HGS), “gait speed” (GS), “biochemical indexes,” “serum IL‐17 level,” nutritional status, and past medical history of the two groups were evaluated and compared. Compared with the participants without sarcopenia, sarcopenia patients had higher average age; less physical exercise; lower total scores of BMI, pre‐ALB, IL‐17, and SPPB; and a higher proportion of malnutrition risk (all P < 0.05). By “ROC curve analysis,” the best critical point was IL‐17 in the growth of sarcopenia. The area that comes under ROC (AUROC) value was 0.627 (95% CI = 0.552, 0.702, P = 0.002). The ideal threshold value for IL‐17 to estimate sarcopenia was 18.5 pg/mL. In the unadjusted model, IL‐17 was considerably linked to sarcopenia (OR = 1.123, 95% CI = 1.037‐1.215, P = 0.004). After the covariate adjustment observed in the complete adjustment model (OR = 1.111, 95% CI = 1.004‐1.229, P = 0.002), this significance still exists. The results of this study suggest a strong relationship between sarcopenia and IL‐17. This study will look at IL‐17’s potential to serve as a key sarcopenia indicator. This trial is registered with ChiCTR2200022590.
Madder (Rubia cordifolia L.) Alleviates Myocardial Ischemia-Reperfusion Injury by Protecting Endothelial Cells from Apoptosis and Inflammation
Authors: Gao Jinwei , Wang Zheng , Ye Zhangzhang
Published: February 2023

Objective. Ischemia-reperfusion injury often occurs in organ transplantation, coronary heart disease, ischemic heart disease, and other diseases, which greatly reduces clinical efficacy. This study examined the effectiveness of madder as a medicine to treat ischemia-reperfusion injury. Methods. The efficacy of madder was evaluated by measuring myocardial infarction size, coronary outflow volume, myocardial contraction rate, activation of inflammatory factors, autophagy factors, apoptosis factors, and related pathway genes in mice. Results. The results indicated that treatment with madder can effectively reduce the area of myocardial infarction and restore arterial blood flow velocity and myocardial contractility in mice. Additionally, madder treatment inhibited the expression of inflammatory factors, autophagy factors, and apoptosis factors in mice and reduced the degree of myocardial cell injury. Studies have also shown that madder treatment can alleviate myocardial ischemia-reperfusion injury in mice and inhibit the occurrence of inflammatory response by inhibiting the activity of the NF-κB pathway. Conclusion. The results showed that madder was effective against ischemia-reperfusion injury, thus showing potential as a clinical drug for treating ischemia-reperfusion injury.
Road Adhesion Coefficient Estimation Based on Second‐Order Linear Extended State Observer
Authors: Wang Jian , Yang Jun , Yu Jinpeng , Wu Mengjun , Li Nan
Published: February 2023

In order to estimate different road adhesion coefficients, a new method based on the second‐order linear extended state observer is proposed to improve the active safety and driving stability of vehicles. The vehicle single‐wheel driving dynamics model and single‐wheel braking dynamics model are built with analyzing the driving and braking processes of the vehicle. The controllers of ASR and ABS are designed by using sliding mode structure control, and the chattering phenomenon of sliding mode control is eliminated by the saturation function. The road adhesion coefficient can be estimated by the second‐order linear extended state observer in real time with the wheel speeds, and driving torque and braking torque are used as input variables. The simulation results show that the road adhesion coefficient estimation method based on the second‐order linear extended state observer can accurately identify the adhesion coefficient of different roads in the presence of external interference and has strong robustness. At the same time, it also provides a reference for the design of the stability control system of unmanned vehicles.
Cascaded Fractional Model Predictive Controller for Load Frequency Control in Multiarea Hybrid Renewable Energy System with Uncertainties
Authors: Gulzar Muhammad Majid , Sibtain Daud , Khalid Muhammad
Published: February 2023

The rapid utilization of electricity has forced the stability of the power system for continuous operation. Due to difference in demand and generation, the frequency reference point changes that needs to be restored to its locus point for the stable operation of the power system. Therefore, a novel efficient control design is propounded to counter the phenomena of load frequency control. The designing of cascaded fractional model predictive controller coupled with fractional-order PID controller (CFMPC-FOPID) is designed for an efficient response of the power system under load disruption and system parameter variations. The controller is optimized by sooty tern optimization algorithm to identify the optimal parameters of the controller. The controller is tested under power mixing of renewable energy sources (i.e., PV and wind) and under varying load scenarios in multiarea hybrid power system. The proposed controller has effectively handled the frequency disruption under distinct load change by stabilizing it in 1.34 sec, 0.60 sec, and 0.41 sec for area-1 with an average time of 0.78 sec, and for area-2, the stabilizing time is 1.40 sec, 0.89 sec, and 0.56 sec with an average time of 0.95 sec, whereas the average time for MPC/PI, DSA-FOPID, GWO: PI-PD, and SCA: FOPI-FOPID is 7.67 sec, 4.68 sec, 1.77 sec, and 4.72 sec, respectively, for area-1 and 6.47 sec, 5.13 sec, 3.45 sec, and 5.02 sec, respectively, for area-2. The outcome result justifies the superiority of the studied technique.
[Retracted] A Blumgart Anastomosis‐Based Half‐Invagination Pancreaticoenterostomy with Better Applicability to Laparoscopy and Lower Incidence of Pancreatic Leakage
Authors: Sun Qiang , Peng Peng , Gong Xueyi , Wu Jianlong , Zhang Qiao , Hu Zhipeng , Chang Xiaojian , Hu Zemin
Published: February 2023

Background. The Blumgart anastomosis (BA) is one of the safest anastomoses for pancreatic stump reconstruction. The incidence of postoperative pancreatic fistula (POPF) and postoperative complications is low. However, how to make laparoscopic pancreaticoenterostomy easier and safer is still a topic to be discussed. Methods. The data of patients who underwent laparoscopic pancreaticoduodenectomy (PD) from April 2014 to December 2019 were analyzed retrospectively. Results. Half‐invagination anastomosis was performed in 20 cases (HI group), and the Cattell‐Warren anastomosis was carried out in 26 cases (CW group). The amount of intraoperative bleeding, operation time, and postoperative catheterization time in the HI group was significantly less than those in the CW group. Besides, the number of patients at the Clavien‐Dindo grade III and above in the HI group was significantly less than that in the control group. Moreover, the incidence of POPF in the HI group was significantly lower than that in the CW group. Furthermore, fistula risk score (FRS) analysis showed that there was no high‐risk group, and the highest risk in the medium‐risk group was pancreatic leakage. In addition, the incidence of pancreatic leakage in the HI group and CW group was 7.7% and 46.67%, respectively, while the incidence of pancreatic leakage in the HI group was significantly lower than that in the CW group. Conclusions. The half‐invagination pancreaticoenterostomy based on the Blumgart anastomosis should have good applicability under laparoscopy and could effectively reduce the incidence of postoperative pancreatic leakage.
Preparation of Nanosize Bone Powder from Waste and Development of Al Composite through Squeeze Casting Process
Authors: Kamatchi R. Muthu , Muraliraja R. , Sabari Bharathi C. , Sathish T. , Sathyaraj S. , Kumar Leevesh
Published: February 2023

Al6061 alloy is most commonly used in automotive, marine, and aerospace applications to lighten the composite and increase its strength. Al6061 alloy is a precipitation-hardened aluminum alloy used as a matrix material. Beef bone is a biowaste that has polluted the environment and the people who live in the vicinity of its manufacturing and disposal sites. Biowaste has been used in a variety of ways by researchers in recent years, including activated carbon, water purification, reinforcement in composites, fillers, additives, etc. Beef bones that had been abandoned as waste were collected, cleaned, and grounded into a fine powder with a particle size of 50–100 nm and used as reinforcement. Squeeze casting process is used to create the newly created aluminum composite (Al6061 + 0%, 5%, 10% of bone powder). The aluminum composite was fabricated and three samples were successfully obtained for further testing and analysis. The prepared Al composites with nanopowder reinforcement are analyzed for surface morphology, elemental identification, hardness, porosity, tensile strength, and compression strength. The percentage of porosity in the composite is improved by 36.7% when compared to the Al6061 alloy. Similarly, the tensile strength of the produced composite is increased to 5.59%. A significant improvement is observed in the wear resistance and hardness of the composite as 54.55% and 48.65%, respectively.
A Simple Method to Produce an Aluminum Oxide-Passivated Tungsten Diselenide/n-Type Si Heterojunction Solar Cell with High Power Conversion Efficiency
Authors: Rehman Malik Abdul , Kim Minjae , Pawar Sachin A. , Park Sewon , Nasir Naila , Kim Dong-eun , Khan Muhammad Farooq , Nguyen Van Huy , Chabungbam Akendra Singh , Seo Yongho , Sakurai Takeaki , Chun Seung-Hyun , Koo Do Hyoung , Lee Chul-Ho , Jun Seong Chan , Park Hyung-Ho
Published: February 2023

Transition metal dichalcogenide (TMDC) materials are attractive candidates for 2D solar cell devices thanks to their straightforward integration with various substrates and traditional semiconductor technologies, wide band gap ranges over the visible light spectrum, and high absorption coefficient values. Although there are several previous reports on the fabrication of 2D material-based solar cells, difficult and complex processes in the fabrication are highly required to be modified for wider use in daily life applications. Photolithography, the most commonly used manufacturing process for TMDC-based solar cells, is complicated. In this study, we demonstrate that the fabrication of 2D tungsten diselenide (WSe2) by adopting a wet transfer process with thermal release tape simplifies the manufacturing steps for TMDC-based solar cell devices. This simplification not only reduces the production cost by excluding several factors such as transmittance, thermal expansion, surface flatness, and durability but also improves the yield. Furthermore, a proof-of-concept demonstration of creating a WSe2/Si junction with an aluminum oxide (Al2O3) antireflective coating provided a power conversion efficiency of 6.39%, which is a significant improvement over that of a WSe2/Si solar cell without the antireflective coating layer (1.08%).
Rapid Dantrolene Administration with Body Temperature Monitoring Is Associated with Decreased Mortality in Japanese Malignant Hyperthermia Events
Authors: Toyota Yukari , Kondo Takashi , Shorin Daiki , Sumii Ayako , Kido Kenshiro , Watanabe Tomoyuki , Otsuki Sachiko , Kanzaki Rieko , Miyoshi Hirotsugu , Yasuda Toshimichi , Horikawa Yousuke T. , Mukaida Keiko , Tsutsumi Yasuo M.
Published: February 2023

Purpose. Malignant hyperthermia (MH) is a rare genetic disorder but one of the most severe complications of general anesthesia. The mortality rate of MH has dropped from 70% in the 1960s to 15% because of dantrolene, the only currently accepted specific treatment for MH. In this study, we retrospectively identified the optimal dantrolene administration conditions to reduce MH mortality further. Methods. Our database performed a retrospective analysis of patients with MH clinical grading scale (CGS) grade 5 (very likely) or 6 (almost certain) between 1995 and 2020. We examined whether dantrolene administration affected mortality and compared the clinical variables associated with improved prognosis. Furthermore, a multivariable logistic regression analysis was used to identify specific variables associated with improved prognosis. Results. 128 patients met the inclusion criteria. 115 patients were administered dantrolene; 104 survived, and 11 died. The mortality rate of patients who were not administered dantrolene was 30.8%, which was significantly higher than those of patients who were administered dantrolene (P = 0.047). Among patients administered dantrolene, the interval from the first sign of MH to the start of dantrolene administration was significantly longer in the deceased than in the survivors (100 min vs. 45.0 min, P < 0.001), and the temperature at the start of dantrolene administration was also significantly higher in the deceased (41.6°C vs. 39.1°C, P < 0.001). There was no significant difference in the rate of increase in temperature between the two, but there was a substantial difference in the maximum temperature (P < 0.001). The multivariable analysis also showed that the patient’s temperature at dantrolene administration and interval from the first MH sign to dantrolene administration was significantly associated with improved prognosis. Conclusions. Dantrolene should be given as rapidly as possible once MH has been diagnosed. Beginning treatment at a more normal body temperature can prevent critical elevations associated with a worse prognosis.
Soil Test Based Fertilizer Calibration for Common Bean (Phaseolus vulgaris L.) Varieties of the Southern Ethiopia
Authors: Kassa Mesfin , Kifle Tadesse
Published: February 2023

Blended Nitrogen, Phosphorus, Sulfur, and Boron fertilizer calibration foxr optimum common bean (Phaseolus vulgaris L.) varieties yield was used to assess the effect of different rates of blended fertilizer on growth, yield and yield components, and nutrient use efficiency of common bean varieties and to identify economically feasible rates of blended fertilizer at Meskan District, Southern Ethiopia during 2020 crop season. The experiment had six treatment levels of blended fertilizer (0, 50, 100, 150, 200, and 250 kg·ha−1), and two common bean varieties were arranged in a randomized complete block design with three replications. Soil samples of the experimental plots were analyzed and used as blended fertilizer calibration to estimate soil nutrient supplies and recommend fertilizer. The results revealed that growth, yield, and yield components were highly significantly

p
≤
0.05

affected by the main effect of varieties and application of blended NPSB rates. The interaction of varieties and blended fertilizer shown a significant

p
≤
0.05

effect on all parameters. The partial budget analysis indicated that the highest net benefit of 67665 ETB ha−1 was obtained from the Nasir variety with the application of 100 kg·ha−1. Therefore, growing the Nasir variety with blended fertilizer rates of 100 kg·ha−1 is economically feasible for the studied soil type and different locations.
Antioxidant and Antiapoptotic Properties of n‐Butanol Fraction the Acanthopanax senticosus Extracts in H2O2‐RAW264.7 Cells and CCl4‐Induced Liver Injury in Mice
Authors: Su Jianqing , Fu Xiang , Liu Ruixue , Zhang Xinyu , Xue Jiaojiao , Li Ying , Zhang Rui , Li Xiaoli , Wang Xiaoya , Wang Xueyan , Ding Yi , Chu Xiuling
Published: February 2023

The Acanthopanax senticosus has been shown to have a wide range of pharmacological activities, which are associated with health benefits, such as antioxidant, anti‐inflammatory, and antiapoptotic properties. A previous study has shown that the n‐butanol fraction of A. senticosus extract had the strongest antioxidant effect in vitro. This study aimed to investigate the effects that the n‐butanol fraction of A. senticosus extract could relieve oxidative stress damage through antioxidant and antiapoptotic in the H2O2‐stimulated RAW264.7 macrophages and the CCl4‐induced liver injury. The result showed that the n‐butanol fraction extract could relieve damage by increasing the intracellular antioxidant enzymes (SOD) level, decreasing intracellular ROS and MDA levels, and regulating antioxidant and antiapoptotic‐related gene expression levels. The morphological observation of HE, TUNE, and immunohistochemistry staining of liver tissue verified that the n‐butanol fraction extract is though anti‐oxidative and antiapoptotic to alleviate cellular oxidative damage. The RT‐PCR assay showed that the Keap1‐Nrf2‐ARE and the Bax/Bcl‐2 signaling pathway were related to the molecular mechanism of action. The experimental results show that Acanthopanax senticosus extract has a good effect in treating liver injury and enhancing the antioxidant capacity of the body.
Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma
Authors: Vasudev Naveen S. , Scelo Ghislaine , Glennon Kate I. , Wilson Michelle , Letourneau Louis , Eveleigh Robert , Nourbehesht Nazanin , Arseneault Madeleine , Paccard Antoine , Egevad Lars , Viksna Juris , Celms Edgars , Jackson Sharon M. , Abedi-Ardekani Behnoush , Warren Anne Y. , Selby Peter J. , Trainor Sebastian , Kimuli Michael , Cartledge Jon , Soomro Naeem , Adeyoju Adebanji , Patel Poulam M. , Wozniak Magdalena B. , Holcatova Ivana , Brisuda Antonin , Janout Vladimir , Chanudet Estelle , Zaridze David , Moukeria Anush , Shangina Oxana , Foretova Lenka , Navratilova Marie , Mates Dana , Jinga Viorel , Bogdanovic Ljiljana , Kovacevic Bozidar , Cambon-Thomsen Anne , Bourque Guillaume , Brazma Alvis , Tost Jörg , Brennan Paul , Lathrop Mark , Riazalhosseini Yasser , Banks Rosamonde E.
Published: February 2023

Purpose:

Patients with resected localized clear-cell renal cell carcinoma (ccRCC) remain at variable risk of recurrence. Incorporation of biomarkers may refine risk prediction and inform adjuvant treatment decisions. We explored the role of tumor genomics in this setting, leveraging the largest cohort to date of localized ccRCC tissues subjected to targeted gene sequencing.

Experimental Design:

The somatic mutation status of 12 genes was determined in 943 ccRCC cases from a multinational cohort of patients, and associations to outcomes were examined in a Discovery (n = 469) and Validation (n = 474) framework.

Results:

Tumors containing a von-Hippel Lindau (VHL) mutation alone were associated with significantly improved outcomes in comparison with tumors containing a VHL plus additional mutations. Within the Discovery cohort, those with VHL+0, VHL+1, VHL+2, and VHL+≥3 tumors had disease-free survival (DFS) rates of 90.8%, 80.1%, 68.2%, and 50.7% respectively, at 5 years. This trend was replicated in the Validation cohort. Notably, these genomically defined groups were independent of tumor mutational burden. Amongst patients eligible for adjuvant therapy, those with a VHL+0 tumor (29%) had a 5-year DFS rate of 79.3% and could, therefore, potentially be spared further treatment. Conversely, patients with VHL+2 and VHL+≥3 tumors (32%) had equivalent DFS rates of 45.6% and 35.3%, respectively, and should be prioritized for adjuvant therapy.

Conclusions:

Genomic characterization of ccRCC identified biologically distinct groups of patients with divergent relapse rates. These groups account for the ∼80% of cases with VHL mutations and could be used to personalize adjuvant treatment discussions with patients as well as inform future adjuvant trial design.
Computed Tomography-Defined Sarcopenia in Outcomes of Patients with Unresectable Hepatocellular Carcinoma Undergoing Radioembolization: Assessment with Total Abdominal, Psoas, and Paraspinal Muscles
Authors: Wu Chih-Horng , Ho Ming-Chih , Chen Chien-Hung , Liang Ja-Der , Huang Kai-Wen , Cheng Mei-Fang , Chang Chih-Kai , Chang Chia-Hung , Liang Po-Chin
Published: February 2023

Introduction: Sarcopenia is an adverse prognostic factor in patients with liver cirrhosis and hepatocellular carcinoma (HCC). Image-based sarcopenia assessment allows a standardized method to assess abdominal skeletal muscle. However, which is an index muscle for sarcopenia remains unclear. Therefore, we investigated whether sarcopenia defined according to different muscle groups with computed tomography (CT) scans can predict the prognosis of HCC after radioembolization. Methods: In this retrospective study, we analyzed patients who underwent radioembolization for unresectable HCC between January 2010 and December 2019. Before treatment, the total abdominal muscle (TAM), psoas muscle (PM), and paraspinal muscle (PS) areas were evaluated using a single CT slice at the third lumbar vertebra. In previous studies, sarcopenia was determined using the TAM, PM, and PS after stratifying by sex. Finally, we investigated each muscle-defined sarcopenia to decide whether or not it can serve as a prognostic factor for overall survival (OS). Results: We included 92 patients (74 men and 18 women). TAM, PM, and PS areas were significantly higher in the men than in the women (all p < 0.05). The patients with sarcopenia defined using PM, but not TAM and PS, exhibited significantly poorer OS than those without sarcopenia (median 15.3 vs. 23.8 months, p = 0.034, 0.821, and 0.341, respectively). After adjustment for clinical variables, such as body mass index, liver function, alpha-fetoprotein level, clinical staging, treatment response, and posttreatment curative therapy, PM-defined sarcopenia (hazard ratio: 1.899, 95% confidence interval: 1.087–3.315) remained an independent predictor for the poor OS. Conclusion: CT-assessed sarcopenia defined using PM was an independent prognostic factor for the poorer prognosis of unresectable HCC after radioembolization.
Out-of-Field Teaching: Impact on Teachers’ Self-Efficacy and Motivation
Authors: Recede Reynald Alfred A. , Asignado Rowena A. , Castro Mark A.
Published: February 2023

he study aimed to determine the impact of having teaching loads assigned to teachers which are not aligned with their preservice training.  The research utilized a descriptive research design and involved 12 senior high school teachers who are teaching in a public national high school in Marikina City, the Philippines for the school year 2019-2020.  The study also made use of the qualitative data gathered through focus group discussion to have an in-depth analysis of the perceptions of the teachers regarding their situation on teaching a subject that is not part of their expertise.  The study revealed that teachers who are assigned teaching loads which are not part of their preservice training showed some confidence that they can teach their students well.  This was shown on the question how confident they were in teaching their students to become critical thinkers and 8 or (66.67 %) of the total number of the teacher participants said that they exerted moderate effort in encouraging students to become critical thinkers.  In addition, 5 or (41.67 %) of the teachers shared that they can do so much to help students improve in his failing grade.  Surprisingly, 7 or (58.33%) of the total number of the teacher participants said that they can only exert moderate effort to help students who are having difficulty with the subject.  Based from the findings of the study, the researchers thought that the perennial problem of teachers being assigned teaching loads that are not in line with their area of expertise should be given enough training and technical assistance coming from the school administration.  This will help improve teachers in their pedagogical techniques and the type of assessment they employ in their classes.
Implementation of The PjBL Learning Model Through Google Classroom in Learning to Write Procedure Texts During the Covid-19 Pandemic
Authors: Marpaung Devi Anisa , Kemala S Sarma Dewi
Published: February 2023

Distance learning activities are a big challenge for teachers because they have never experienced it before. Project-based learning through Google Classroom is an alternative method that can be applied by teachers in distance learning activities (PJJ). The purpose of this study was to determine whether the project-based learning model through Google Classroom could be applied to the learning activities of class IX-9 students of SMP Negeri 8 Pematangsiantar. Project-based learning grammar, namely, first, basic questions, second, designing product plans, third, preparing a manufacturing plan, fourth, monitoring project activities and development, fifth, test results, and sixth, evaluating the learning experience. The results showed that the average student could write the program text correctly. Student performance can be described with an average score of 82 points, the highest score of 95 points, and the lowest score of 70 points. There is 1 person with a score of 95, 3 students with a score of 89, and 7 students with a score of 89. 86, 2 students have 85 points, 6 students have 83 points, 3 students have 79 points, 2 students have 77 points, and 71 students have 7 points.
Analysis of Leading Sectors in Improving the Economy East Java Province in 2016-2020
Authors: Sutrisno Sutrisno
Published: February 2023

East Java is a province that has a major influence on national GDP, therefore it is necessary to know which economic sectors can survive and be redeveloped so that the economy of East Java can return to stability as it was before the Covid-19 pandemic occurred. This research approach is a quantative research. This research uses variables, namely the economic sector. The location to carry out this research is East Java Province. The data collection methods used are documentation and literature studies. The data analysis techniques used are Location Quotient (LQ) and Dynamic Location Quotient (DLQ). There are 5 economic sectors in East Java that are included in the base sector or leading sectors at the time before the Covid-19 pandemic (2016-2019) and during the Covid-19 pandemic (2020) based on the results of the location quotient analysis. Meanwhile, based on the results of the dynamic location quotient analysis, it is known that there are 9 economic sectors in East Java Province in the 2016-2020 period which are potential sectors to be developed.
Move Up, Live Up: Dance Activities as a Way of Motivating Students Participating in Progressive Limited Face-to-face Classes
Authors: Recede Reynald Alfred A. , Bulay-og Leah Sablayan , Reyes Joyce E.
Published: February 2023

Dancing is a popular form of physical exercise. Researches have shown that dancing can increase self-esteem and improve our mind and body to become more productive. The aim of this study is to explore the impact of "Galaw Pilipinas" calisthenics exercise on the motivation of students as they go back to face-to-face classes. The sample for this study is composed of 16 female and 15 male Senior High School students of a public national high school in Marikina City. Senior High School students' pretest results; mean score was 87.52, the standard deviation was 4.67 and the standard error mean was 0.84. While the Senior High School students' posttest results; mean score was 95.87,  the standard deviation was 3.24 and the standard error mean was 1.96. A paired samples t-test was conducted to evaluate the impact of the Galaw ng Pilipinas dance routine on student motivation. The results showed a significant increase in the marks of the students’ pretest (M = 87.52, SD =4.67 to posttest (M = 95.87, SD = 3.24), t = 9.1399, n = 31, p= .0001 which is less than 0.05 (two-tailed). By conventional criteria, this difference is considered to be statistically significant. Hence, the dance routine greatly affects the increase in motivation of the students.
English Language: Commonly Used Instructional Materials in Teaching and Learning
Authors: Ordu Stanley , Better Odukwu
Published: February 2023

This study investigates the survey of instructional materials commonly used by teachers in teaching and learning of English Language in Selected Junior Secondary Schools in Ogba/Egbema/Ndoni Local Government Area of Rivers State. Five research questions were used to guide the study. The population of the study was 1,230 respondents from Junior Secondary School Students and 120 respondents were used for the study. Twenty five research questionnaires (25) items were raised from the research questions and were analyzed using a four point Likert scale. A benchmark of 2.5 was used as a criterion for agreement. Conclusion and recommendations were made based on the following. Teachers should always try their best to make use of available visual instructional materials necessary to make their lessons more interesting, teachers are encouraged to search for necessary visual instructional materials that can appeal to the sense of learners, arouse their interest, encourage their participation, making learning more meaningful and promote academic standard, school principles should provide teachers with enabling environment for the use of available instructional material to give room for participatory studentship and make learning more meaningful, government should supply teaching aids and finance schools to improvise unavailable and inadequate instructional materials to make teaching and learning easier, practical, appealing and enjoyable.
Factors Affecting the Enrollment of Criminology at King’s College of the Philippines
Authors: Gambulao Jr. Ruben M. , Depayso Dempsey O.
Published: February 2023

College enrollment is an important decision for all aspiring students of higher education. This study investigates the factors affecting the enrollment of freshmen college students at King’s College of the Philippines-College of Criminal Justice Education (KCP-CCJE). Data has been collected through questionnaire. Mean and percentage were used to determine the main reasons of the respondents. Selected factors were ranked by the respondents from their most reasons and least reason from 1-10.  The sample size was 191, consisting of freshman students who have enrolled during the first semester of Academic year 2020-2021. Results showed that academic program, college reputation, and influence from others are the most reason of the respondents in enrolling in the college.
Implementation of Educational Technology in the Development Area in Christian Religious Education in the Digital Age
Authors: Butar-butar Imelda , Sitorus Jim , Rantung Dyoys Aneke , Boiliu Noh Ibraihm
Published: February 2023

Along with effort transformation in field education , technology education have very important role. In article this outlined about application technology education area development. For get inside data article this, done study descriptive qualitative with use method observation and interview to three lecturers Christian religious education and some students in the faculty psychology, faculty agriculture and faculty technique. From fifth area technology education, by special article this discuss application technology education area development in Christian religious education in the digital age concerns aspect technology print, audio visual technology, technology based computer and multimedia technology.
The Effectiveness of Providing Student Worksheets in an Effort to Improve Science Learning Outcomes for Class V Elementary School Students
Authors: Nadrah Nadrah
Published: February 2023

This research aims; (1) to obtain an overview of the science learning outcomes of the fifth grade students of SD Negeri Kalukuang II Makassar who were taught by giving Student Worksheets, (2) to obtain an overview of the science learning outcomes of the fifth graders of SD Negeri Kalukuang II Makassar who were taught without the provision of Student Worksheets , and (3) To examine the science learning outcomes of fifth grade students of SD Negeri Kalukuang II Makassar who were taught by giving student worksheets without giving student worksheets. Based on the results of data analysis and discussion of research results, it can be concluded that; (1) The results of data analysis show that the average score of science learning outcomes for fifth grade students of SD Negeri Kalukuang II Makassar who are taught by giving Student Worksheets is 16.1563 from an ideal score of 20 with a standard deviation of 3.44, (2) The results of the analysis The data shows that the average score of fifth grade science learning outcomes at SD Negeri Kalukuang II Makassar who are taught by giving Student Worksheets is 12.5313 from an ideal score of 20 with a standard deviation of 3.689, and (3) After analyzing the data derived from If the population is normally distributed and homogeneous, a hypothesis research is conducted where the probability (P = 0.000) is smaller than (α = 0.05) so that it is stated that there is a difference between the science learning outcomes of fifth grade students of SD Negeri Kalukuang II Makassar  who are taught with giving Student Worksheets -and those who are taught without giving Student Worksheets. Thus, it can be concluded that the science learning outcomes of fifth grade students of SD Negeri Kalukuang II Makassar who are taught by giving student worksheets are better than those taught without giving student worksheets.
Study of Damage to Residential Buildings, Soil Geophysics and The Relationship Between the Epicentrum Distance and the Level of Damage Caused by Earthquake
Authors: Sangadji Abdul R , Osok Rafael M , Talakua Silwanus M
Published: February 2023

The earthquake that occurred on September 26 2019 caused considerable damage to residential buildings in Ambon City, Central Maluku District and West Seram. This research was carried out in the villages of Liang, Tulehu and Waai, Salahutu District, Central Maluku Regency, which experienced the most damage, namely 5,406 houses were lightly damaged, 1,483 were moderately damaged, and 866 were heavily damaged. This study examines the characteristics of residential buildings, and analyzes the relationship between the level of damage to residential buildings and the distance from the epicenter. Coordinates and data on the level of damage to residential buildings (slight, moderate, very heavy) were obtained from BPBD Maluku Province, data on building characteristics including building construction, basic building conditions, building materials, building age were collected through field surveys and interviews with building owners based on damage level data building. The results showed that the level of damage to residential buildings was related to age/length, structure/construction, and materials used for building walls. The damage is even more severe if the building is old (> 20 years), the construction is boneless and unbuttoned (only the bricks are stacked), and the brick material is made of sea sand. Meanwhile, houses built with plastered masonry walls are more resistant to earthquakes. There is a relationship between the level of damage to residential buildings and the epicenter, the closer to the epicenter the damage is more severe, while the farther from the epicenter the level of damage is mild to moderate.
Art Preservation Through Karang Taruna Empowerment in Mekar Jaya Village : A Case Study of Kompangan Arts and Traditional Dance
Authors: Waluyo Hadi , Wahyuni Anny
Published: February 2023

Indonesia is a country that is rich in culture which is the identity of a nation. One area that has its own culture is Jambi province with its Kompangan culture and traditional dances. However, the rapid development of digitalization has forced the Kompangan culture and traditional dance to be pushed aside. Especially among the youth who are currently more interested in foreign cultures that enter Jambi. Therefore, we need a container that is able to develop and preserve this culture. At this writing using a descriptive qualitative approach with data collection techniques carried out by observation, interviews, documentation and data validation. From the interview, an answer was found for the problems faced by culture in the village of Mekar Jaya by creating an art gallery through the empowerment of Karang Taruna Mekar Jaya. This studio will later conduct training on Kompangan art and Tri art traditionally every week. It is hoped that the existence of this studio can raise awareness to preserve Kompangan arts and dance arts and can foster a sense of pride in the culture that belongs to the village of Mekar Jaya.
Implementation of Bound Morpheme Through A Text to The Students of HKBP Nommensen Pematangsiantar University
Authors: Munthe Melda Veby Ristella
Published: February 2023

Words are composed of morphemes. The notion that morphemes are words is not necessarily true. While some single morphemes can function as words, some words have two or more morphemes. Furthermore, it is wrong to consider morphemes to be syllables. In contrast, many words only have one syllable and two morphemes; examples are "cats," "runs," and "barked." Morpheme can be classified as either Free or Bound Morpheme. It applies the Bound Morpheme's restriction, which included eight inflectional affixes. The goal is to determine how pupils use bound morphemes. This study's research tool was acquired through testing. Knowing the sort of error and where it happens helps with testing. The procedures for data analysis were applied by the data analysis methodologies. Counted the Bound Morpheme first. Second, they were divided into groups. Thirdly, the number of frequently occurring terms was counted. Fourthly, determined which word should be chosen and which should not be. Then, based on the total number of words with the ratings Excellent, Good, Fair, and Poor, percentages were calculated. Meanwhile, based on the results of the The student’s ability in implementing the Inflectional Affixes is 38% as a very good category, 25% as a good category, 25% as a fair category, and 12% as a low category in implementing the Inflectional Affixes of Bound Morpheme on the text.