bluuebunny/crossref_metadata_2025 huggingface dataset:
Tantangan Pembentukan Identitas Kampung Besek dan Pemberdayaan Perempuan di Desa Tegaren
Authors: Mijiarto Joko , Wahyuni Wahyuni , Nuryananda Praja Firdaus , Ahzani W.K. Faizin
Published: March 2022

Desa Tegaren yang terletak di Kecamatan Tugu, Kabupaten Trenggalek, memiliki potensi tinggi untuk menjadi destinasi pariwisata baru di Jawa Timur. Sebagai salah satu kawasan penyangga wisata daerah kabupaten, Desa Tagaren memiliki kawasan embung yang terletak di dataran tinggi. Kekayaan alam ini semakin memberikan nuansa pariwisata di Tegaren. Potensi lainnya adalah kekayaan budaya masyarakat Tegaren yang mana hampir 95% dari penduduk di Tegaren memiliki pekerjaan sampingan sebagai pengrajin besek bambu. Kebudayaan kerajinan besek bambu ini merupakan warisan dari para sepuh di desa tersebut. Penelitian yang kami lakukan menggunakan pendekatan community based tourism (CBT) dan asset-based community development (ABCD). Penelitian yang kami lakukan di Desa Tegaren berusaha menelaah peran perempuan di Desa Tegaren yang meningkatkan keberdayaannya melalui usaha kerajinan besek bambu. Penelitian ini menggunakan metode observasi partisipatif yang kami lakukan selama kurang lebih dua tahun berjalan. Hasil kajian yang kami kembangkan dari penelitian ini mendapati bahwa keinginan untuk membentuk sebuah konsep desa wisata di Desa Tegaren juga mendapat dukungan dan partisipasi besar dari para penduduk perempuan di desa. Tiga temuan dari penelitian ini adalah terdapat tiga tantangan dalam pembentukan identitas kampung besek berdasarkan peran perempuan di Tegaren, yakni posisi sosio-kultural perempuan yang masih belum memiliki rekognisi sosial di masyarakat, ketimpangan harga beli dan harga jual, serta adanya potensi penurunan minat terhadap kerajinan besek oleh generasi muda.
Studi Eksploratif Tentang Sentra Jamu Tradisional Di Daerah Istimewa Yogyarta Sebagai Daya Tarik Wisata Kesehatan
Authors: Hadi Wisnu
Published: March 2022

Setiap aktivitas perjalanan wisatawan pasti ada yang memberi pengaruh pada orang lain dan pengaruh tersebut akan memberi keuntungan bagi wisatawan dan orang lain. Salah satunya adalah wisata Kesehatan dimana banyak yang mencari para wisatawan seperti mendatangi tempat tempat wisata yang dapat memberikan kekebalan tubuh disaa pandemi Covid-19 ini. Para wisatawan banyak tertarik dengan mengkonsumsi minuman herbal salah satunya dengan minum jamu tradisional. Banyak sentra-sentra jamu tradisional di Daerah Istimewa Yogyakarta seperti Gesikan, Kiringan dan Argomulyo yang menghasilkan produk jamu tradisional yang bisa menjadi andalan untuk dijual sebagai wisata Kesehatan dan pendidikan. Dengan metode penelitian deskriptif kualitatif peneliti melakukan kajian studi eksploratif tentang  sentra jamu tradisional di Daerah Istimewa Yogyakarta sebagai daya tarik wisata kesehatan dengan mencari data primer berupa pustaka dan observasi sehingga hasil penelitian dianalisis bahwa aktivitas pengolahaan jamu tradisional di desa Kiringan dan Argomulyo di Kabupaten Bantul serta desa Gesikan di Kabupaten sudah dikembangkan menjadi wisata Kesehatan selama ini. Hal ini temuan di desa Kiringan di Bantul sudah dibuat paket wisata yang berhubungan dengan jamu tradisional dari membuat, mengolah serta mengemas kemudian ikut menikmati jamu tersebut. Kemudian di Argomulyo Bantul juga sudah dikemas dengan mendirikan Omah Jamu dimana wisatawan bisa ikut menikmati olahan jamu yang sudah dikemas lebih modern. Serta data di desa Gesikan olahan jamu juga dikembangkan menjadi minuman untuk jamuan di hotel sebagai minuman welcome drink saat wisatawan masuk ke hotel.
Usando Policiamento Liderado por Inteligência para Combater Assaltos a Bancos no Rio Grande do Norte, Brasil
Authors: Silva Wellington Clay Porcino
Published: March 2022

Os Roubos a Bancos são um dos maiores desafios enfrentados pela polícia no Brasil,principalmente seu tipo mais violento, conhecido como “Novo Cangaço”. Esse tipo decrime ocorre quando uma quadrilha de muitos criminosos fortemente armados atacauma pequena cidade, usando violência e intimidação como armas para assaltar todosos bancos que existem naquele local. Esse problema é ainda maior na Região Nordestedo Brasil. Durante este trabalho vamos mostrar como o Intelligence Led Policing ,uma das mais modernas técnicas de gestão policial foi empregada pelas polícias federale estadual para reduzir os assaltos a bancos no Rio Grande do Norte, um dos estados lo-calizados na Região Nordeste do Brasil. Também apresentaremos como podemos usaruma técnica de Machine Learning para ajudar os tomadores de decisão da polícia aselecionar as melhores opções para maximizar o impacto.
Projeto de Coleta de Amostra de Condenados – interação nacional e cumprimento legal em prol da justiça
Authors: Minervino Aline Costa
Published: March 2022

A legislação brasileira determina que condenados por crime doloso praticado com violência grave contra a pessoa, bem como por crime contra a vida, contra a liberdade sexual ou por crime sexual contra vulnerável devem, obrigatoriamente, ser identificados pelo perfil genético. Em 2017, cinco anos após o surgimento da previsão legal, pouco mais de dois mil condenados tinham seus perfis inseridos no Banco Nacional de Perfis Genéticos. Ademais, estes eram oriundos de apenas dez unidades da federação; portanto, a maioria dos estados brasileiros não vinham cadastramento os perfis genéticos de condenados. Com o objetivo de execução do cumprimento da legislação brasileira aplicada à identificação criminal pelo perfil genético por todas as unidades da federação, bem como para o fortalecimento da Rede Integrada de Bancos de Perfis Genéticos como ferramenta de auxílio para apuração criminal e para a instrução processual, surge o Projeto de Coleta de Amostra de Condenados. O Projeto, desenvolvido e executado nos anos de 2018 e 2019, contou com a participação de todas as unidades da federação e resultou no expressivo crescimento (2.897%) da inserção de perfis genéticos de condenados (2.008 em 28 de novembro de 2017 comparado a 60.184 em 31 de dezembro de 2019). O aumento expressivo de inserção de perfis genéticos de indivíduos identificados criminalmente resultou em maior efetividade dos bancos de perfis genéticos como ferramenta para o auxílio de investigações. No período de dois anos, as coincidências (matches) observadas na RIBPG cresceram 277% (376 em 28 de novembro de 2017 comparado a 1.418 em 28 de novembro de 2019).
Epistemología de los derechos humanos
Authors: Alvarez Jairo Enrique Suárez
Published: March 2022

El objetivo de esta ponencia es plantear cómo los derechos humanos constituyen un núcleo epistemológico de convergencia entre la ciencia, la moral y política. Más allá de las dificultades para su implementación y de los incesantes conflictos, la Declaración de 1948 se mantiene y proyecta aún en el siglo XXI como un referente paradigmático para fundamentar y legitimar la acción gubernamental del Estado de derecho. En el caso de la ciencia policial (entendida como ciencia de Estado), y de manera específica con relación a la actividad policial (científica y general), el supuesto es que los criterios científicos garantizan -o pueden garantizar- el respeto, la protección y promoción de aquellos derechos. Entre tanto, los avances científicos y tecnológicos parecen superar o soslayar los problemas políticos y morales de una sociedad humana en crisis y en permanente alteración. Y, en este mismo sentido, la ciencia no es necesariamente garante de derechos, sino, además, un campo de conocimiento para replantear, por ejemplo, conceptos como libertad, vida, justicia y seguridad pública, entre otros. En este contexto ¿cómo desde una epistemología de los derechos humanos se articulan la ciencia, la moral y la política? La hipótesis de esta cuestión considera que el Estado -a través de la actividad científica policial- debe analizar los diferentes paradigmas epistemológicos de conocimiento y su relación con los DH. Tales paradigmas determinan (y determinarán) las nuevas interpretaciones sobre los fundamentos y las características de los DH en el presente siglo, al tiempo que desafían (y desafiarán) el orden jurídico-social donde la ciencia, la moral y la política confluyen conflictivamente.
O Seminário Internacional de Ciências Policiais e Criminalidade Organizada
Authors: Ribeiro Marcos Leôncio Sousa
Published: March 2022

A Revista Brasileira de Ciências Policiais (RBCP) nesta edição especial apresenta o dossiê “Ciências Policiais, Inteligência Policial e Criminalidade Organizada”, resultado da produção científica do Seminário Internacional de Ciências Policiais e Criminalidade Organizada, realizado no período de 21 a 25 de junho de 2021, pela Academia Nacional de Polícia (ANP), em parceria com a Universidade Autônoma de Lisboa (UAL), de Portugal, nos termos do Acordo de Cooperação Institucional celebrado com a Polícia Federal (PF) em 2018.
CASC15 Promotes Lens Epithelial Cell Apoptosis in Age-Related Cataracts by Regulating MiR-139-5p/caspase-3
Authors:   Department of Ophthalmology, Miyun Teaching Hospital Affiliated to Capital Medical University, Beijing, China, Wu Teng-Fei , Liu Ying ,   Department of Ophthalmology, Miyun Teaching Hospital Affiliated to Capital Medical University, Beijing, China, Guo Xiu-Hua ,   Department of Ophthalmology, Miyun Teaching Hospital Affiliated to Capital Medical University, Beijing, China
Published: March 2022

Objective: The aim of this study was to reveal the role of CASC15 and miR-139-5p function in regulating agerelated cataracts (ARC). Methods: The expression of CASC15, miR-139-5p and caspase-3 were detected by qRT-PCR. Western blot was used to analyze the level of apoptosis-related proteins. Flow cytometry was used to measure the apoptosis of SAR01/04l cells treated with UV irradiation. Results: The expression of CASC15 and caspase-3 in the lens of ARC was higher than that in normal lens, but the expression of miR-139-5p had opposite trend. The level of caspase-3 and Bax were increased and Bcl-2 was decreased in ARC group. In addition, CASC15 negatively regulated miR-139-5p expression and promoted SAR01/04l cell apoptosis. CASC15 could combine with miR-139-5p, and miR-139-5p could combine with caspase-3 3’-UTR. Furthermore, pcDNA-caspase-3 could reverse the inhibitory effect of si-CASC15 and miR139-5p mimic on SRA01/04 cell apoptosis. Conclusion: CASC15 promoted lens epithelial cell apoptosis by regulating miR-139-5p/caspase-3. Keywords: ARC; CASC15; LECs apoptosis; miR-139-5p
The Need for Rectifying Heterodoxies and Flawed Science in Publications on Contraception and Birth Control
Authors: Kraetschmer Kurt
Published: March 2022

The research article responds to the need for assessing a steadily increasing number of publication material devoted to contraceptive products. By way of a critical analysis it is found that an unexpected high number of health agencies and publishers disseminate heterodoxies and flawed science on contraception. To avert continuation of flawed science and perpetuation of error, it is suggested that health agencies involve only competent researchers in the production of their information material, that editors refrain from publishing adulterated research conducted by authors with conflicting interests, and that pharmacovigilance expands its activities and assesses -- under the nomenclature “pharmaceuticovigilance” -- the documents generated by manufacturers for approval as well as for effective marketing of their products.
The Potential Therapeutic Effect of Hypertonic Saline Solution (HSS) for the Management of Refractory Acute Decompensated Heart Failure (ADHF)
Authors: Farah Raymond
Published: March 2022

Patients with acute decompensated heart failure (ADHF) have high rates of mortality and morbidity despite recent improvements in diagnosis and treatment. Still patients with significant heart failure and especially with NYHA class III -IV HF and low blood pressure with or without hyponatremia and renal failure are considered severe patients with reduced response to standard treatment with high mortality rates and high re-hospitalizations as they are associated with worse prognosis. Several works and meta -analysis have shown the importance and benefit of treatment with the infusion of hypertonic saline solution (HSS) in these patients and in different conditions of cardiovascular collapse. Current evidence indicates that the infusion of hypertonic solution in heart failure patients can provide clinical and hemodynamic improvement. The investigators are testing the hypothesis that the infusion of hypertonic solution in association with diuretics may prevent the occurrence of renal dysfunction in patients with ADHF and can reduced the re-hospitalizations rate. Our experience in treating several patients has been successful and has shown significant improvement in symptoms and weight loss and improvement in renal function, due to the small size of the sample we were unable to perform a controlled study. We hypothesize that HSS, treatment should be adopted practically and a treatment protocol should be built in patients with intractable ADHF, especially with hypotension, hyponatremia with/without renal failure and overloaded.
Congenital Heart Diseases among Children in Selected Hospital
Authors: Mamun-ur-Rashid Al , Hai Russeel Mohammed Zaglul , Hossain Akanda Md. Belayet
Published: March 2022

Background: Congenital heart disease (CHD) is the most common type of birth defect. As CHD accounts for the most frequent cause of lethal malformation among infants, CHD is also considered a major problem affecting public health worldwide. Objective: To assess pattern of congenital heart diseases and associated risk factors among under-14 children admitted in a selected hospital. Methods: It was cross sectional analytical study conducted among purposively selected 111 children admitted in Children Hospital for treatment. Face to face interview was conducted to collect data. The cases were included in the study when the diagnosis of CHD was established by medical records and echocardiography. Results: About 91% and 9% children came from <1 year and 1-5 year age group. Low birth weight and normal birth weight was 52% and 48%. Pre-term and term distribution was 37% and 63%. About half of the respondents were middle class. About 26%, 25% and 18% mothers consumed vitamin A (>10000 IU/d), anti-pyretics and NSAIDs during pregnancy. About 40% mothers consumed contaminated tap water and 29% mothers were exposed to radiation. Ventricular septal defect (40.5%) and atrial septal defect (36.9%) were prominent. Patent ductus arteriosus and pulmonary stenosis were 8.1% and 5.4%. Statistical significant association was found between ventricular septal defect and birth weight, gestational age and monthly family income. As like VSD, atrial septal defect showed statistical significant association with birth weight, monthly family income, maternal age and rubella infection 6 months prior to conception or 1st trimester. Conclusion: Ventricular septal defect (40.5%) and atrial septal defect (36.9%) were common among children. Maternal nutrition during pregnancy should be emphasized due to prevent low birth weight and pre-term baby.
PRP Injection versus Surgical Method for Treatment of Tennis Elbow: Case Report
Authors: Ghiasi Mahdieh , Mehdizadeh Mohamad , khatib shad Liela , Madani Hoda
Published: March 2022

Objective: Tennis elbow is damage of tendon fibers that happens in any age group. It appears with severe pain and inflammation and functional limitations. Now days, none operative methods have been considered. PRP (platelet rich plasma) injections are helpful in treating tennis elbow. Methods: In this method, whole blood obtained and concentrated the platelets, and injected into elbow. After that, patient should wear splint for month. Results: it leads one month to see the evidence of recovery in pain and range of motion in patient. Conclusion: We found that PRP injection can be considered as a safe and effective tool for intractable lateral epicondylitis of the elbow and eliminated the need for surgical intervention.
Chronic Low Back Pain and its Sustainable Management by Using Core Strengthening Exercise and Mechanical Traction
Authors: Hossain Delwar
Published: March 2022

This experimental study was conducted to determine the effectiveness of neural mobilization and conventional physiotherapy technique in patients with chronic low back pain with a sample of 100. The study reveals that the mean age of the core muscle strengthening group was 33.88+(or)-10.77 years whereas mechanical traction group was 42.46+(or)-9.51 years of age. Study shows that mean BMI of core muscle strengthening group and mechanical traction group was 24.05+(or)-4.329 and 25.28+(or)-4.562. Study found that the mean severity of pain before treatment was 6.380+0.725 and after treatment was 2.74+(or)-0.921 of core muscle strengthening and the mean severity of pain before treatment was 7.100+(or)-0.839 and after treatment was 3.64+(or)-1.173. Study shows that mean score Oswestry low back pain disability index of core muscle strengthening before treatment was 20.54+3.7 and after treatment was 7.94+(or)-3.419, compare to mechanical traction before treatment was 22.88+(or)-3.127 and after treatment was 11.92+(or)-4.004. There was statistically highly significant findings of core muscle strengthening and mechanical traction where t-value was 35.665 and 26.938 which was measured by Universal pain Assessment Tool, another statistically highly significant finding of core muscle strengthening and mechanical traction where t-value were 21.995 and 19.039 which was measured by Oswestry low back pain disability index.
Design of Photovoltaic as Energy Source at Government Office in Pangkalpinang
Authors: Ferdiansyah Ahmad , Putra Ghiri Basuki , Sunanda Wahri
Published: March 2022

In the regulation of the general energy plan for the Bangka Belitung region, it is targeted that the total use of new and renewable energy will reach 17.21% in 2025 and 30.97% in 2050. This, of course, requires a measurable implementation to achieve this. In this regard, a photovoltaic design was carried out as a source of electrical energy in one of the government offices in Pangkalpinang. This office's daily demand for electrical energy is 78.79 kWh, with an average solar irradiance of 487.51 W/m2 and a measured ambient temperature of 26o – 33.3o C. The modeling is carried out using three types of photovoltaic panels, a namely polycrystalline, monocrystalline and thin film with a supply power is combined with a source from PLN and 100% photovoltaic
Analisa Pengujian Ketahanan Bejana Tekan Dengan Metode Hidrostatictest
Authors: Siswanto Budi
Published: March 2022

A pressure vessel is a place or container for storing or building fluids, both in the form of liquids and gases as one of the process tools used in industry, especially in the chemical, petroleum, and electricity generation industries with steam separators which are very important components in electricity generation. The steam separator is used to separate the fluid in the liquid phase and gas phase (steam or steam) to produce a higher level of dryness and more contained in the steam that will be used to turn the turbine. Based on the ASME VIII standard in 2010 which was a vessel before it could be used in payment and one type of testing was by hydrostatic test method. From the calculation of the voltage that occurs when hydrostatic administration is 5.037 MPa (50.37 Bar), the force that divides the locked flange 8 bolts M-16 x 2.0 (P), with the introduced voltage (τ) inside the pressure vessel, at what is permitted τ (that occurs (40 N / mm2 ≥ 36 40 N / mm2. from the test results using hydrostatic test methods obtained for hydrostatic testing can determine leakage and test with 1.5 x work work (30 bar) steam separator pressure vessel no defects appear, crank on the weld or deformation occurs.
Analisis Kebutuhan Bandwith dan Kuota Internet pada Penggunaan Nirruang Syarah UMRAH berbasis BigBlueButton
Authors: Rathomi Muhamad Radzi , Chahyadi Ferdi , Yuniati Ika Putri
Published: March 2022

Pada masa pandemi ini, kuliah dalam jaringan menjadi hal yang sangat baik untuk diterapkan. Universitas Maritim Raja Ali Haji telah memiliki media pembelajaran dalam jaringan yang disebut dengan Syarah UMRAH. Aplikasi Syarah UMRAH memiliki fitur tatap muka melalui jaringan yang memanfaatkan aplikasi pihak ketiga, yaitu BigBlueButton. Fitur tatap muka ini masih dalam masa percobaan, dimana terjadi kendala seperti bandwith yang dibutuhkan oleh server dan kuota internet pengguna yang harus disediakan. Oleh karena itu, diperlukan analisis untuk menemukan patokan bandwith dan kuota tersebut. Penelitian ini melakukan percobaan dengan melihat penggunaan bandwith pada saat kamera diaktifkan dengan memperhatikan keadaan setiap kualitas kamera digunakan. Selain itu, perbandingan juga dilihat dari penggunaan kamera pada computer dan pada smartphone. Hasil yang diperoleh dari penelitian ini adalah prakiraan kuota yang dibutuhkan ketika pengajar menggunakan kamera dengan kualitas HD pada aplikasi BigBlueButton, yaitu sebesar 416,24 MB jika hanya satu pengajar dan satu murid, dan 1,15 GB jika 30 peserta yang masuk ke aplikasi BigBlueButton
Critical Thinking Against Pseudoscience
Authors: Griftsova Irina N.
Published: March 2022

This review article analyses the literature on critical thinking and pseudoscience and characterises critical thinking as an instance of scientific thinking and a tool for the criticism of pseudoscience. The authors of the review work on the assumption, first made in a 1998 presentation, that critical thinking lies at the interface of logic and anthropology. The concept of critical thinking is shown to be widely used of late in the Russian and international discourse on research and education. The term also frequently occurs in public statements by politicians, economists, lawyers, and even members of the clergy and the army. An emphasis is placed on critical thinking being a value of society in and of itself, which should be considered along three dimensions, namely as a philosophical concept, a methodological approach based on that concept, and an academic discipline either independent or embedded in some other subject area. Sources in the references aid in analysing each of these dimensions. The section dealing with critical thinking in its relation to pseudoscience surveys various approaches to demarcating and defining pseudoscience and gives an overview of the literature analysing the role of critical thinking in detecting and fighting pseudoscience and fakes in science. This analytical review of works on critical thinking and its role in distinguishing science and pseudoscience is concise compared to the almost inexhaustible body of literature on the topic. Yet, it demonstrates the importance of the subject matter for Russian and international research.
Ressourcen – Gesundheit zwischen Eigenverantwortung und gesellschaftlicher Verantwortung
Authors: Bigga Regine
Published: March 2022

Die Herstellung und Aufrechterhaltung von Gesundheit und Wohlergehen wird in vielen Diskursen als alleinige Aufgabe des Individuums angesehen. Die Ressource Gesundheit hängt vom individuellem Verhalten ab, aber auch von gesellschaftlichen Rahmenbedingungen. Es wird der Frage nachgegangen, welche äußeren Bedingungen sich negativ oder positiv auf die Bildung der Ressource Gesundheit auswirken.
Multifidus muscle cross-sectional area adaptations over two volleyball seasons and one off-season in athletes with and without low back pain
Authors: Sponbeck J.K. , Moody M.A. , Mitchell U.H. , Neves C.D. , Johnson A.W.
Published: March 2022

BACKGROUND: The multifidus muscle is important in spine stabilization. Atrophy of the multifidus muscle has been associated with low back pain. OBJECTIVE: To examine multifidus muscle cross-sectional area (CSA) adaptations over two volleyball seasons and one off-season in volleyball athletes experiencing low back pain or no low back pain. METHODS: Twelve female NCAA division 1 volleyball athletes participated. Athletes were placed into a low back pain or no low back pain group. Athlete’s multifidus was imaged and measured using ultrasound at four time points across seasons. Imaging time points were before season one, following season one, following off-season, and following season two. A single level mixed-model analysis of variance was used for all analyses. A Tukey HSD post hoc test was used to determine differences between and within the low back pain and the no low back pain groups. RESULTS: Following off-season training the pain group had clinically significant smaller multifidus CSA at the L4 (-2.36 cm2 difference or 17.5%) and L5 (-2.40 cm2 or 12.5%) levels. Non-significant (p> 0.05) decreases in multifidus CSA were seen in both groups following season one and two. Athletes with pain had decreased multifidus CSA at the L4 and L5 vertebral levels at all time points which was non-significant (p> 0.05). CONCLUSIONS: Clinically significant decreases in multifidus CSA occurred in female volleyball athletes with low back pain at the L4 and L5 level following off-season training. Volleyball athletes with pain had smaller multifidus CSA averages at all time points measured of the two year period.
Anomaly repair-based approach to improve time series forecasting
Authors: Thu Thuy Huynh Thi , Tuan Anh Duong , Ngoc Chau Vo Thi
Published: March 2022

Time series forecasting has many practical applications in a variety of domains such as commerce, finance, medicine, weather, environment, and transportation. There exist so many methods developed for time series forecasting. However, most of the forecasting methods do not pay attention to anomalies in time series even though time series are sensitive to anomalies. Anomaly patterns cause negative effects on the accuracy of time series forecasting. In this paper, we propose a novel anomaly repair-based approach to improve time series forecasting in the case of anomaly existence. In our approach, an effective time series forecasting framework, EPL_S_X, is proposed with anomaly smoothing as a pre-processing stage and any existing time series prediction algorithm X. In particular, our proposed approach consists of three steps including detecting anomalies, repairing anomalies by using our smoothing method, and forecasting time series using preprocessed time series. Experimental results on several time series datasets reveal that our proposed approach improves remarkably the accuracy of many existing time series forecasting methods. It also outperforms the two robust time series forecasting methods that are based on exponential and Holt-Winters smoothing. With such better prediction performance, our approach is not only more effective but also more useful when dealing with anomalies in time series forecasting.
Learning transferable and discriminative features for unsupervised domain adaptation
Authors: Du Yuntao , Zhang Ruiting , Zhang Xiaowen , Yao Yirong , Lu Hengyang , Wang Chongjun
Published: March 2022

Although achieving remarkable progress, it is very difficult to induce a supervised classifier without any labeled data. Unsupervised domain adaptation is able to overcome this challenge by transferring knowledge from a labeled source domain to an unlabeled target domain. Transferability and discriminability are two key criteria for characterizing the superiority of feature representations to enable successful domain adaptation. In this paper, a novel method called learning TransFerable and Discriminative Features for unsupervised domain adaptation (TFDF) is proposed to optimize these two objectives simultaneously. On the one hand, distribution alignment is performed to reduce domain discrepancy and learn more transferable representations. Instead of adopting Maximum Mean Discrepancy (MMD) which only captures the first-order statistical information to measure distribution discrepancy, we adopt a recently proposed statistic called Maximum Mean and Covariance Discrepancy (MMCD), which can not only capture the first-order statistical information but also capture the second-order statistical information in the reproducing kernel Hilbert space (RKHS). On the other hand, we propose to explore both local discriminative information via manifold regularization and global discriminative information via minimizing the proposed class confusion objective to learn more discriminative features, respectively. We integrate these two objectives into the Structural Risk Minimization (RSM) framework and learn a domain-invariant classifier. Comprehensive experiments are conducted on five real-world datasets and the results verify the effectiveness of the proposed method.
Association Between Use of Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors and Cognitive Function in a Longitudinal Study of Patients with Type 2 Diabetes
Authors: Low Serena , Goh Kiat Sern , Ng Tze Pin , Moh Angela , Ang Su Fen , Wang Jiexun , Ang Keven , Tang Wern Ee , Lim Ziliang , Subramaniam Tavintharan , Sum Chee Fang , Lim Su Chi
Published: March 2022

Background: The association between sodium-glucose cotransporter-2 inhibitors (SGLT2i) use and cognitive function in type 2 diabetes remains unclear. Objective: Explore the association between SGLT2i and longitudinal changes in cognitive function in adults with type 2 diabetes (T2DM) and assessed the cognitive domains which were impacted by SGLT2i. Methods: We conducted a prospective cohort study of 476 patients aged 60.6±7.4 years with follow-up period up to 6.4 years. Data on SGLT2i use was derived from questionnaire and verified with clinical database. We used Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess cognition. The association between SGLT2i use and rate of RBANS score change was examined using multiple linear regression. Results: There were 138 patients (29.0%) on SGLT2i, including 84 (17.7%) for < 3 years and 54 (11.3%) for ≥3 years. SGLT2i use was positively associated with RBANS total score increase in language (coefficient 0.60; 95% CI 0.10–1.11; p = 0.019) in unadjusted analysis. This positive association persisted in fully adjusted model (coefficient 0.74; 95% CI 0.12 to 1.36; p = 0.019). SGLT2i use for ≥3 years was positively associated with RBANS score increase globally and in language domain in fully adjusted analysis with coefficients 0.54 (95% CI 0.13 to 0.95; p = 0.010) and 1.12 (95% CI 0.27 to 1.97; p = 0.010) respectively. Conclusion: Our findings revealed a previously unobserved association between ≥3 years SGLT2i use and improved cognitive scores globally and in language domain and executive function. Future studies should investigate the role of SGLT2i in ameliorating cognitive decline.
Rough uniformity of topological rough groups and L-fuzzy approximation groups
Authors: Ahsanullah T. M. G.
Published: March 2022

Starting with an approximation space as the underlying structure, we look at the rough uniformity of a topological rough group. Next, taking L as a complete residuated lattice, we consider L-subgroup and normal L-subgroup of a group to create the L-fuzzy upper rough subgroup, and the L-fuzzy lower rough subgroup within the framework of the L-fuzzy approximation spaces. Here we particularly focus on a category of L-fuzzy upper rough subgroups, and a special kind of category of L-closure groups that arises naturally. We introduce the notion of the L-fuzzy approximation group, and study some of its properties including the usual function space structure for the L-fuzzy approximation spaces. Furthermore, using the notion of an L-fuzzy upper approximation operator, we investigate some categorical connection between the L-fuzzy approximation groups, and the L-closure groups. In a similar fashion, using an L-fuzzy lower approximation operator, we investigate the categorical connection between the L-fuzzy approximation groups, and the L-interior groups.
A robust tuned classifier-based distributed denial of service attacks detection for quality of service enhancement in software-defined network
Authors: Kaur Gaganjot , Gupta Prinima
Published: March 2022

In today’s world, Software-Defined Networking (SDN) plays a significant role in the advancement of next-generation network architecture that offers vast control to the network operators. However, the control layer is vulnerable to Distributed Denial of Service (DDoS) attacks where DDoS is one of the most powerful and devastating cyber-attacks. Thus, the development of a DDoS attack detection mechanism is very essential since these kinds of attacks have a direct impact on the overall performance of the SDN. In this paper, a new robust Tuned support vector machine-based DDoS attack detection methodology has been proposed to categorize the benign traffic from DDoS attack traffic on the SDN. Primarily, the network is created with controller and OpenFlow switch and the communication can be carried out through secure channels among different benign users and also attackers. Afterward, the multi-characteristic values are extracted by the effective extraction strategy which consists of the six-tuple characteristic values matrix. Finally, the tuned classifier has been implemented with the aid of optimization algorithm for differentiating the abnormal traffic and the normal traffic. The performance results manifest that the proposed detection framework achieves a higher accuracy of 98% and precision of 99% when compared with existing classifiers.
RETRACTED: CEEMDAN hybridized with LSTM model for forecasting monthly rainfall
Authors: Kala A. , Ganesh Vaidyanathan S. , Sharon Femi P.
Published: March 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Semantic similarity based food entities recognition using WordNet
Authors: Butt Sahrish , Bakhtyar Maheen , Noor Waheed , Baber Junaid , Ullah Ihsan , Ahmed Atiq , Basit Abdul , Kakar M. Saeed H.
Published: March 2022

Unstructured text processing is the first step for several applications such as question answering systems, information retrieval, and recipe classification. In the field of recipe classification, number of frameworks have been proposed. However, it is still very tedious and time consuming to extract the food items from the unstructured text and then process for classification. In this research, an automatic food item detection from unstructured text is proposed based on semantic sense modeling. The candidate nouns are detected which can be food items and then the similarity of those nouns is computed with possible food categories. The candidate noun is treated as food item if the similarity is high. For similarity between possible food item and food category is computed by WordNet ontology. The proposed framework is evaluated on benchmark datasets and competitive performance have been achieved. The F-score on large dataset that contains around 20 K recipes is 0.89 which is improved from 0.56.
Minimizing pressure inhomogeneities across large samples under helium pressure media at low temperatures
Authors: Leão Juscelino Batista
Published: March 2022

When using gas pressure media to achieve hydrostatic pressure under a constant pressure and volume, passing through the melting curve ([Formula: see text]) of the gas to achieve low temperatures (1.5 K ⩽ T < 30 K) will cause an overall pressure reduction at base temperatures of at most 25 percent of the pressure read while under hydrostatic conditions at the [Formula: see text]. In-situ inert gas high pressure vessels for neutron scattering for pressures of up to 1.0 GPa and temperatures as low as 1.5 K pose a particular problem due to the [Formula: see text] phase diagram of the pressure media. A methodology for pressurization to ensure minimal pressure loss as temperature falls below the pressure media phase change, at the same time minimizing pressure inhomogeneity throughout the length of the sample; as well as calibration data are presented within this work.
Intrinsic motivation for using a wearable hip exoskeleton
Authors: Roggeman Stijn , Firouzi Mahyar , Lefeber Nina , De Keersmaecker Emma , Cuypers Lotte , Swinnen Eva , Joos Erika , Schiltz Marc , Hatem Samar M.
Published: March 2022

BACKGROUND:

Walking difficulties put an individual at high risk of falling, institutionalisation and even death. The use of robotical rehabilitation or assistive devices for walking has gained considerable interest as a means of improving patients’ gait abilities.

OBJECTIVE:

The aim of this research was to examine patients’ intrinsic motivation to train with a wearable hip exoskeleton (Honda Walking Assist).

METHODS:

Rehabilitation patients (stroke, medullar lesion, orthopaedic surgery) and elderly ([Formula: see text] 65 yrs) with walking difficulties were recruited for this study ([Formula: see text] 23). Each walked with the Honda Walking Assist for 30 minutes during one therapy session and completed the Intrinsic Motivation Inventory (IMI) afterwards.

RESULTS:

All participants presented with high scores on the IMI, in particular for the items ‘interest/enjoyment’ (median: 43; 25[Formula: see text]–75[Formula: see text] perc.: 37–46; maximal score: 49), ‘perceived competence of walking’ (35 [31–38]; max. score 42) and ‘value/usefulness’ (44 [35–49]; max. score 49).

CONCLUSIONS:

This robotic exoskeleton for assisted walking was considered a valuable device by the majority of participants, eliciting a high degree of motivation and enjoyment.
Application value of gray-scale ultrasound and shear wave elastography in differential diagnosis of thyroid nodules
Authors: Zhou Qian , Xu Ping , Ding Hong , Wang Yong , Fu Lina , Wang Bo , Liu Danru
Published: March 2022

BACKGROUND: The global prevalence of thyroid cancer has increased significantly in recent years. Ultrasonography is the preferred method for differentiating benign and malignant thyroid nodules preoperatively and is recommended by guidelines. OBJECTIVE: To assess the application value of gray-scale ultrasound and shear wave elastography in distinguishing small thyroid nodules. METHODS: A retrospective analysis of 228 thyroid nodules, all of which were confirmed by pathology after surgery or FNA from January 2019 to January 2020, was carried out. All nodules were divided into a ⩽ 5 mm group and a > 5 mm group according to their maximum size. We compared the differences in the gray scale and elastography of the nodules between the two groups and the accuracy of different diagnostic methods. RESULTS: The accuracies of gray-scale ultrasound and shear wave elastography in the ⩽ 5 mm group were found to be lower than those in the > 5 mm group, and the gray-scale accuracy was slightly higher than that of shear wave elastography in both groups (p< 0.05). The largest AUC (area under the curve) of elastic parameters in the ⩽ 5 mm and > 5 mm groups was found for Emax and Esd, respectively. Based on a combination of these two parameters, the accuracies of the two groups were significantly higher than those of the parameters or gray scale alone (p< 0.05) and were 84.62% and 85.48%, respectively. CONCLUSION: Shear wave elastography is valuable in the diagnosis of benign and malignant thyroid nodules using ultrasonography. When combining gray-scale ultrasound and shear wave elastography, the diagnostic accuracy is obviously improved, especially for ⩽ 5 mm small thyroid nodules.
Usability evaluation of an interactive leg press training robot for children with neuromuscular impairments
Authors: Chrif Farouk , van Hedel Hubertus J.A. , Vivian Mauro , Nef Tobias , Hunt Kenneth J.
Published: March 2022

BACKGROUND: The use of robotic technology for neurorehabilitative applications has become increasingly important for adults and children with different motor impairments. OBJECTIVE: The aim of this study was to evaluate the technical feasibility and usability of a new interactive leg-press training robot that was developed to train leg muscle strength and control, suitable for children with neuromuscular impairments. METHODS: An interactive robotic training system was designed and constructed with various control strategies, actuators and force/position sensors to enable the performance of different training modes (passive, active resistance, and exergames). Five paediatric patients, aged between 7 and 16 years (one girl, age 13.0 ± 3.7 years, [mean ± SD]), with different neuromuscular impairments were recruited to participate in this study. Patients evaluated the device based on a user satisfaction questionnaire and Visual Analog Scale (VAS) scores, and therapists evaluated the device with the modified System Usability Scale (SUS). RESULTS: One patient could not perform the training session because of his small knee range of motion. Visual Analog Scale scores were given by the 4 patients who performed the training sessions. All the patients adjudged the training with the interactive device as satisfactory. The average SUS score given by the therapists was 61.2 ± 18.4. CONCLUSION: This study proposed an interactive lower limb training device for children with different neuromuscular impairments. The device is deemed feasible for paediatric rehabilitation applications, both in terms of technical feasibility and usability acceptance. Both patients and therapists provided positive feedback regarding the training with the device.
Screening of periodontitis-related diagnostic biomarkers based on weighted gene correlation network analysis and machine algorithms
Authors: Ji Juanjuan , Li Xudong , Zhu Yaling , Wang Rui , Yang Shuang , Peng Bei , Zhou Zhi
Published: March 2022

BACKGROUND: Periodontitis is a common oral immune inflammatory disease and early detection plays an important role in its prevention and progression. However, there are no accurate biomarkers for early diagnosis. OBJECTIVE: This study screened periodontitis-related diagnostic biomarkers based on weighted gene correlation network analysis and machine algorithms. METHODS: Transcriptome data and sample information of periodontitis and normal samples were obtained from the Gene Expression Omnibus (GEO) database, and key genes of disease-related modules were obtained by bioinformatics. The key genes were subjected to Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and 5 machine algorithms: Logistic Regression (LR), Random Forest (RF), Gradient Boosting Decisio Tree (GBDT), Extreme Gradient Boosting (XGBoost), and Support Vector Machine (SVM). Expression and correlation analysis were performed after screening the optimal model and diagnostic biomarkers. RESULTS: A total of 47 candidate genes were obtained, and the LR model had the best diagnostic efficiency. The COL15A1, ICAM2, SLC15A2, and PIP5K1B were diagnostic biomarkers for periodontitis, and all of which were upregulated in periodontitis samples. In addition, the high expression of periodontitis biomarkers promotes positive function with immune cells. CONCLUSION: COL15A1, ICAM2, SLC15A2 and PIP5K1B are potential diagnostic biomarkers of periodontitis.
Evolutionary Frequency of Initially Sequenced Human Coronavirus Genomes
Authors: Ur Rahman Hamid , Majaz Sidra , Saeed Aamir , Ahmad Ashfaq
Published: March 2022

A novel, human-infecting coronavirus causing COVID-19 was first identified in Wuhan, China in December 2019. Within a short span of time the virus recorded more than 1 million deaths, worldwide. This study addresses the overall evolutionary process from complete genomes of COVID-19. Addressing the complexity of the task, network-based approaches were used in mapping samples to their reported locations. A total of 473 complete human coronavirus genomes from 20 different countries were studied, including samples from 17 states of the United States and samples from the Cruise-Diamond Princess. The phylodynamic network of a global scale was classified into five clusters containing two clusters of the samples from the USA. Cluster B was a shared cluster of samples from China and the USA, while clusters A and C were of a diverse nature. Chinese samples aggregated in clusters A and B which aided in retaining the homogeneous viral genomic pool. In contrast, samples from the USA and Spain were split into distinct clusters which indicated multiple port entries and a possibility of implying a delay in quarantine measures. In the intra-USA samples, we found that sequences reported from Washington and Virginia were scattered indicating evolutionary diversity. This report provides an insight into the transmission pattern of CoV2, which is complicated to evaluate exclusively through the conventional surveillance means.
Epigenetic Alterations of DLL4 and Hes5 in Acute Lymphoblastic Leukemia (ALL)
Authors: Kousar Tayyba , Fatima Noor , Hassan Syeda Saleha , Sadaf Saima
Published: March 2022

Acute lymphoblastic leukemia (ALL) is a hematologic condition with more than a quarter of pediatric cancers. Aberrant promoter methylation of Notch pathway genes causes the deactivation of TSGs. The pathway is also considered a crucial factor in the pathogenesis of ALL due to its active involvement in B and T cell development. Hypermethylation of Notch pathway genes has been reported previously. In this study, the promoter methylation frequency of genes DLL4 and Hes5 of the Notch pathway were studied using methylation-specific PCR in 30 pediatric ALL blood samples against 10 healthy controls. The objective of the study was to find the subtype-specific diagnostic biomarker for ALL. Hypermethylation frequency of DLL4 in pre-B ALL and T-ALL samples was found to be 84.21% and 100%, respectively. Whereas, Hes5 showed 100% mixed methylation in both diseased and control samples. The results predicted the possible epigenetic changes of Notch pathway and the possible role of DLL4 as a diagnostic biomarker of ALL.
Single Cell Sequencing, Its Application and Future Challenges
Authors: Saleem Misbah , Alam Sadaf , Kainat Iqra , Iftikhar Ramsha , Ijaz Aqsa
Published: March 2022

Single-cell sequencing investigates the differences in proteomic and genetic information about individual cells by using next-generation sequencing technologies. Sequencing of the whole genome, epigenome, and transcriptome involves the heterogeneous process of diagnosis, progression, and treatment of disease. Previous studies show that only a few selected proteins and RNAs can be measured but recent molecular studies explore that advances in next-generation sequencing and whole genome amplification enabled us to examine the differences among a variety of transcriptomic cells, gene expression, and phenotypic expressions. In our study, we try to summarize different technologies and their applications at single-cell level in diverse fields such as embryology, oncology, immunology, neurology, microbiology, tissue and organ development, antibody screening, and stem cell research.
The Analyzing miR-106b-5p and miR-93-5p as Promising Diagnostic Markers for Autism Spectrum Disorder
Authors: Safdar Ayesha , Khurshid Sobia , Farwa Umme , Bakhtiar Syeda Marriam
Published: March 2022

Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders encompassing perturbations in verbal and non-verbal communication, social skills, as well as repetitive and restricted behaviour, activity, or response. The pathogenesis of the disorder is still unknown, yet several studies have documented the involvement of both genetic and environmental factors in its onset. Intense efforts have been made to identify reliable biomarkers to aid in early diagnosis. MicroRNAs (miRNAs) are the regulatory noncoding regions of ribonucleic acid (RNA) that can alter the expression of a gene through posttranscriptional mechanisms. In this study, an in-silico technique was used to identify two novel biomarkers, namely miR-106b-5p and miR-93-5p. The analysis identified that these diagnostic biomarkers are associated with ASD and can aid in its early treatment since miRNAs play a significant role in the development and function of the central nervous system (CNS).