bluuebunny/crossref_metadata_2025 huggingface dataset:
Difusão de conceitos da Física Moderna através da plataforma Moodle: O que é realmente Quântico do ponto de vista científico?
Authors: Filho Milton Baptista , Filho Leandro Carvalho Pinto
Published: May 2023

Neste trabalho, trataremos do relato de experiência da iniciativa desenvolvida entre os meses de julho e setembro de 2020. A iniciativa consistiu na oferta de curso livre na modalidade EaD. O curso foi ofertado abertamente ao público em geral e contou com mais de 300 inscritos dos diversos níveis de formação. A proposta do curso surgiu naquele contexto de discussão sobre a relevância da ciência acerca do enfrentamento da covid-19 e do crescente uso do termo Quântico em pseudociências e abordagens inadequadas e incorretas. Os fenômenos reconhecidos a partir de 1900 são fenômenos cuja abordagem passa a considerar seus níveis de energia não mais contínuos, mas discretos, ou seja, em valores definidos, de onde vem a origem do termo Quantum e de onde deriva a palavra Quântico. A grande revolução trazida por esses fenômenos e o grande paradigma constituído transformou a física e a tecnologia. No entanto, lamentavelmente, vem atualmente recebendo usos incorretos e associações indevidas. Portanto, a proposta da oferta do curso veio como apoio a essa necessidade de divulgação científica em nossa região. Neste trabalho, vamos descrever a proposta desse curso e discutir resultados obtidos analisando o perfil dos cursistas e suas opiniões.
Redes neuronais com protótipos para quantificar os determinantes do desempenho acadêmico
Authors: Beatriz-Afonso Ana , Cruz-Jesus Frederico , Castelli Mauro , Oliveira Tiago , Nunes Catarina
Published: May 2023

Desde os anos 50 do século passado que o desempenho académico tem sido foco de interesse por parte de investigadores e decisores políticos. No entanto, apenas recentemente os métodos de ciência de dados começaram a ser aplicados de forma mais sistemática a este tema. Este trabalho utiliza os dados dos exames nacionais de matemática e português da população portuguesa no ano letivo 2018/2019 para, através de redes neuronais, avaliar e comparar quais os fatores que afetam os resultados desses exames, e de que forma. Além disso, uma nova abordagem é apresentada para lidar com o dilema da "caixa negra" dos métodos de ciências de dados mais avançados. Esta abordagem passa pela criação de um conjunto de protótipos através de Redes Neuronais, fornecendo uma estimativa de quanto cada potencial impacta o desempenho acadêmico.
Microbial interactions and the homeostasis of the gut microbiome: the role of Bifidobacterium
Authors: Martin Alberto J.M. , Serebrinsky-Duek Kineret , Riquelme Erick , Saa Pedro A. , Garrido Daniel
Published: May 2023

The human gut is home to trillions of microorganisms that influence several aspects of our health. This dense microbial community targets almost all dietary polysaccharides and releases multiple metabolites, some of which have physiological effects on the host. A healthy equilibrium between members of the gut microbiota, its microbial diversity, and their metabolites is required for intestinal health, promoting regulatory or anti-inflammatory immune responses. In contrast, the loss of this equilibrium due to antibiotics, low fiber intake, or other conditions results in alterations in gut microbiota composition, a term known as gut dysbiosis. This dysbiosis can be characterized by a reduction in health-associated microorganisms, such as butyrate-producing bacteria, enrichment of a small number of opportunistic pathogens, or a reduction in microbial diversity. Bifidobacterium species are key species in the gut microbiome, serving as primary degraders and contributing to a balanced gut environment in various ways. Colonization resistance is a fundamental property of gut microbiota for the prevention and control of infections. This community competes strongly with foreign microorganisms, such as gastrointestinal pathogens, antibiotic-resistant bacteria, or even probiotics. Resistance to colonization is based on microbial interactions such as metabolic cross-feeding, competition for nutrients, or antimicrobial-based inhibition. These interactions are mediated by metabolites and metabolic pathways, representing the inner workings of the gut microbiota, and play a protective role through colonization resistance. This review presents a rationale for how microbial interactions provide resistance to colonization and gut dysbiosis, highlighting the protective role of Bifidobacterium species.
Recent Progress of ZnO-Based Nanoparticle: Synthesizing Methods of Various Dopant and Applications
Authors: Rauf Nurlaela
Published: May 2023

This review focus on the effect of doping rare earth metals, transition metals, noble metals, poor metals, and non-metals on ZnO nanoparticles. ZnO is a semiconductor material with an average wide energy band gap of 3.2 eV. The doping is used to improve the properties of ZnO which strongly depend on their application. The concentration of doping, the type of doping and the process using sol-gel, hydrothermal and precipitation methods are affected in modifying the ZnO lattice parameters. The transition metal widely used for photocatalysts and sensors. The doped application of ZnO nanoparticles as a semiconductor material has proven advantageous in enabling various photocatalytic, glucose biosensors, VOC detection sensors, antibacterial, biomedical, and optoelectronic spintronic, LED, NLO, and silicon solar cells. This review provided information for scientist in choosing the synthesizing methods of ZnO with desired properties and application in future.
The Factor of Women's Entrepreneurship in Competitiveness: Bibliometric Analysis
Authors: Setiani Setiani , Sopiah Sopiah
Published: May 2023

This study aims to determine the factor of women entrepreneurship and analyze publication trends by knowing the number of articles, citations, most authors, and network clusters. This research is the first step to looking at existing research and finding research themes related to women's entrepreneurship. The method used is bibliometric analysis. Data was obtained through a database search, google scholar, by using the software Harzing's Publish or Perish. Initial results obtained as many as 509 articles were then extracted by only taking articles from reputable international publishers, so 72 articles were used. The study results show that the most frequently cited authors are Fauzi et al. (2020). Words often appear: women, entrepreneurship, women entrepreneur, women entrepreneurship, and studies. Bibliometric mapping supports the scientific explanation between probability theory and proof. Women's research Entrepreneurship can be developed more broadly on themes that appear few and have yet to be widely included in research in the last five years. Therefore, this research is expected to be a reference for further research on problems, training, challenges, cases, and rural women.
Restauration et reconnexion des marais littoraux, une solution d’adaptation aux changements climatiques ? Synthèse d’un colloque
Authors: DÈBRE Célia , STURBOIS Anthony , SALGUEIRO-SIMON Manuel , GÉLINAUD Guillaume , PÉTILLON Julien , GALLET Sébastien , LOMBARDI Anne
Published: May 2023

Du 27 au 29 octobre 2021, à Brest, la restitution des résultats du programme de recherche « Pertinence environnementale de la restauration de petits prés et marais salés – PEPPS) a été l’occasion d’un colloque sur l’avenir des marais littoraux à l’aune des changements globaux. Cent-quarante participants – enseignants-chercheurs, étudiants, représentants des collectivités et des administrations territoriales, techniciens, bureaux d’études, experts, gestionnaires d’espaces naturels… – se sont retrouvés pour partager leurs expériences et connaissances acquises sur les marais et leur restauration. Ces trois journées ont ainsi permis de faire le point sur l’état des connaissances à travers différents programmes de recherche récents, développés à l’échelle nationale, et les données issues de l’expérience des gestionnaires d’espaces protégés. Elles auront été également l’occasion de s’interroger collectivement sur l’avenir incertain de ces espaces littoraux, en commençant par définir ce qu’ils recouvrent de milieux, de concepts et de perceptions. Cet article de synthèse retrace les idées fortes qui ont structuré les échanges.
Relationship between Parent-Adolescent Interaction and the likelihood of Internalizing and Externalizing Problems Among Adolescents
Authors: Majid Betty Nadhroh Ummah , Widyasari Dian Caesaria , Karmiyati Diah , Syakarofath Nandy Agustin
Published: May 2023

Adolescence is a transition phase from childhood to adulthood characterized by many drastic changes that make them vulnerable to internalizing and externalizing problems. However, parents can guide in managing the crisis by establishing warm, meaningful, and open interactions with adolescents. Therefore, this study examines the relationship between parent-adolescent interactions on the likelihood of experiencing internalizing and externalizing problems. This quantitative correlational study involved 180 participants from six Junior High Schools in East Java, selected through simple random sampling. Two instruments used were the Parent-Child Interaction Questionnaire-Revised Child Version (PACHIQ-R CH) and the Strenght and Difficulties Questionnaire (SDQ). Simple linear regression analysis indicated a significant effect of parent-adolescent interaction on internalizing and externalizing problems. It is suggested that parent-adolescent interactions contribute to the likelihood of adolescents experiencing internalizing and externalizing problems. Building warm, meaningful, and open interactions with adolescents assume to assist them in understanding the adaptive way of expressing emotions and overcoming the drastic changes during the transitional period.
Peran Self-Compassion sebagai Mediator antara Dimensi Attachment dan Kualitas Hubungan Pacaran Dewasa Muda
Authors: Angela Irene , Setiasih Setiasih
Published: May 2023

Dating relationship is time for individual get to know his partner before decide to get married or not. Therefore, dating relationship quality become important because poor dating relationship quality can negatively affect marital relationship quality. Prior researcher found that individual’s attachment can affect dating relationship quality and self-compassion can mediated attachment and relationship quality. The mechanism of attachment effect was also found to be mediated by self-compassion but this still needs further investigation. The objective of this research is to examine the role of self-compassion in mediating attachment and relationship quality. This research uses quantitative research method by distributing online questionnaire. Total participant of this research is 176 people. Mediation analysis in this research using PROCESS within SPSS. The result of this research shows that self-compassion cannot mediating attachment and dating relationship quality. In other words, individual’s behavior toward himself did not affect individual’s perception toward his relationship or his partner. The next researchers are suggested to do dyadic research, analyses using type of attachment, and examine deeper about self-compassion as the mediator variable.
Closed Form Solution to the Roots of a Quadratic Equation over the Quaternions
Authors: Solomon Edward King
Published: May 2023

This article derives the closed form solution to finding the roots of a quadratic equation in SU3.
Monkeypox Outbreak in Peru: Reflections after the COVID-19 Pandemic
Authors: Ramírez-Soto Max Carlos
Published: May 2023

Monkeypox is a zoonotic illness caused by the Orthopoxvirus monkeypox virus (MPXV). Since 1970, outbreaks of MPXV have occurred in several Sub-Saharan African countries. However, from May 2022 to April 2023, recent outbreaks of MPXV occurred in several countries outside of Africa, and these cases quickly spread to over 100 non-endemic countries on all continents. Because of this, in July 2022, World Health Organization declared monkeypox a Public Health Emergency of International. MPXV disproportionately affects men who have sex with men and members of the HIV-infected population. The current strategy for control and pre-exposure prophylaxis or post-exposure prophylaxis for people at high risk is vaccination. In this context, Peru has the fourth-highest number of MPXV cases in Latin America. Because of this, in this review, we describe public health indicators in Peru and reflect on the COVID-19 pandemic so that health authorities can join forces to identify and control MPXV transmission routes.
Self-Assembly of Porous Hierarchical BiOBr Sub-microspheres for Efficient Aerobic Photooxidation of Benzyl Alcohol under Simulated Sunlight Irradiation
Authors: Wang Zhigang , Liu Cheng , Chen Fengxi , Chen Rong
Published: May 2023

Semiconductor photocatalytic performances can be modulated through morphology modification. Herein porous hierarchical BiOBr microspheres (BiOBr-MS) of ~3 m was firstly self-assembled without the assistance of a template via a facile solvothermal synthesis in triethylene glycol (TEG) at 150 oC for 3 h. KBrO3 was exploited as a bromine source, which slowly provided bromide ions upon reduction in TEG and controlled the growth and self-assembly of primary BiOBr nanoplates. The addition of PVP during solvothermal synthesis of BiOBr-MS reduced the particle size by about three-fold to generate BiOBr sub-microspheres (BiOBr-sMS) of <1 m. BiOBr-sMS exhibited significantly higher photocatalytic activity than BiOBr-MS for aerobic photooxidation of benzyl alcohol (BzOH) to benzaldehyde (BzH) under simulated sunlight irradiation (conversions of BzOH (50 mM) over BiOBr-sMS and BiOBr-MS were respectively 51.3% and 29.6% with 100% selectivity to BzH after Xenon illumination for 2 h at 25 oC). The photogenerated holes and •O2- were found to be main reactive species for the BzOH oxidation over BiOBr spheres by scavenging tests and spin-trapping EPR spectra. The higher photocatalytic activity of BiOBr-sMS was attributed to its more open hierarchical structure, efficient charge separation, more negative conduction band position and generation of larger amounts of •O2-.
Occurrence and Damage Levels of Thaumatotibia leucotreta on Capsicum in Selected Counties in Lower Eastern, Kenya
Authors: Oundo Judith Nabwire , Ndlela Shepard Nabwire , Azrag Abdelmutalab G. A. , Kilalo Dorah , Olubuyo Florence , Mohamed Samira Abuelgasim
Published: May 2023

The false codling moth (FCM), Thaumatotibia leucotreta (Meyrick), is believed to have originated from Ethiopia and sub-Saharan Africa. Currently, this pest has extensively spread and is found in most parts of Africa, with records in approximately 40 countries in over 100 host plant species. Despite Thaumatotibia leucotreta being the leading cause of interceptions of Capsicum and cut flowers exported by Kenya to the European Union, information on abundance and damage levels inflicted on capsicum is limited. The objective of the study was to assess the abundance and damage levels of T. leucotreta on capsicum in the selected counties in Lower Eastern Kenya (Kitui, Machakos, and Makueni counties). Higher T.leucotreta larval density per farm was recorded in Kitui County compared to other counties. In farms with capsicum only (not intercropped with other crops), the mean number of FCM larvae was relatively higher in Kitui. Farming practices such as the use of uncertified seeds and seedlings and the excessive use of pesticides may be the major contributors to high larval incidence in Kitui County.
Knocking Out OsNAC050 Expression Causes Low Temperature Tolerance in Rice by Regulating Photosynthesis and the Sucrose Metabolic Pathway
Authors: Wang Bo , Wang Yiheng , Xie Likun , Yu Wancong , Lan Qingkuo , Wang Yong , Chen Chengbin , Zhang Yong
Published: May 2023

Because rice is native to tropical and subtropical regions, it is generally more sensitive to cold stress compared to other cereals. Low temperature stress has become one of the most important conditions that affects the growth, development, and yield of rice. Plant NAC (NAM, ATAF1/2, and CUC) transcription factors are known to play significant regulatory roles in the stress response. In our research, we found that OsNAC050 (LOC_Os03g60080） is mainly expressed in leaves, and low temperature can further up-regulate its expression. OsNAC050 mutants created using CRISPR-Cas9 gene editing technology showed significantly enhanced tolerance to low temperature treatment. Detection of enzyme activities related to the redox pathway also showed that the mutants had stronger viability under low temperature stress. Comparative transcriptome analysis showed that photosynthesis and soluble sugar metabolism were significantly affected in the osnac050 mutant lines, suggesting that OsNAC050 may participate in the above molecular pathways in the response to low temperature stress. The results will enhance our understanding of molecular mechanisms underlying the responses to cold stress in rice and can provide new strategies for engineering cold-tolerance in high-yielding rice varieties.
Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn
Authors: Ferreira Noely E. , Da Costa Antonio Charlys , Kallas Esper , Silveira Cassia G.T. , Soares Ana Carolina , Honorato Layla , Paiao Heuder Gustavo Oliveira , Lima Silvia Helena , Vasconcelos Dewton M. , Côrtes Marina F. , Costa Silvia Figueiredo , Tozetto-Mendoza Tania Regina , Gomes Hélio Rodrigues , Witkin Steven S. , Mendes-Correa Maria Cassia
Published: May 2023

Parvovirus B19 infection is associated with a wide range of clinical manifestations, from asymp-tomatic to severe neurological disorders. Its major clinical symptoms, fever and rash, are com-mon to multiple viruses, and laboratory tests to detect B19 are frequently not available. Thus, the impact of B19 on public health remains unclear. We report the case of a 38-day old girl ad-mitted to São Paulo Clinical Hospital, Brazil, with an initial diagnosis of bacterial meningitis, seizures, and acute hydrocephalus. Antibiotic therapy was maintained for one week after admis-sion and discontinued after negative laboratory results were obtained. Nine days after symp-toms onset, a cerebral spinal fluid (CSF) sample revealed persistent pleocytosis. The complete B19 complete genome was subsequently identified in her CSF by a metagenomic next-generation sequencing approach. This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations, and emphasizes that its possible involve-ment might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.
The Effect of Boron (B) on the Microstructure and Graphite Morphology of Spheroidal Graphite Cast Iron
Authors: Ha Jin-Su , Hong Ji-Woo , Kim Ji-Wook , Han Soo-Bin , Choi Chang-Young , Song Hye-Jin , Jang Jin-Seok , Kim Dong-Yul , Ko Dae-Cheol , Yi Seong-Hoon , Cho Yong-Jae
Published: May 2023

This study investigated the impact of boron and copper on the microstructure and mechanical properties of Spheroidal graphite Cast Iron (SCI). The addition of boron increased the ferrite content, while copper increased the stability of pearlite. The interaction between boron and copper significantly increased the ferrite content. Differential Scanning Calorimetry (DSC) revealed that boron decreased the enthalpy change of the α + Fe3C -> γ transformation and increased the enthalpy change of the α -> γ transformation. The addition of boron and copper reduced the tensile and yield strength but increased elongation and impact energy. The findings provide valuable insights into the effect of boron and copper on SCI, facilitating the design and development of high-performance SCI materials.
Methane Dry Reforming Catalysts Based on Pr-doped Ceria-Zirconia Synthesized in Supercritical Propanol
Authors: Arapova Marina , Smal Ekaterina , Bespalko Yuliya , Valeev Konstantin , Fedorova Valeria , Hassan Amir , Bulavchenko Olga , Sadykov Vladislav , Simonov Mikhail
Published: May 2023

This work is devoted to the study of active and stable nickel catalysts for methane dry reforming based on Pr-doped ceria-zirconia obtained by solvothermal continuous method. The studies of physicochemical and catalytic properties of the 5%Ni\Ce0.75Zr0.25-xPrxO2 series showed that Pr introduction leads to an increase in the amount of highly reactive oxygen of the oxide lattice. Praseodymium-based catalysts showed significantly higher reactant conversions. In addition to the nature of support, the method of nickel introduction was also studied - Ni was added both by impregnation and one-pot with mixed oxide preparation. The method of Ni addition was shown to have significant effect on the morphology of the supported active component and, respectively, on the catalytic activity. The 5%Ni/Ce0.75Zr0.15Pr0.1O2 catalyst prepared by one-pot method showed stable operation in the MDR reaction for 30 hours at CO2 and CH4 conversions of ~40% and an H2 yield of ~18% (Т=700°С, τ=10ms).
Acute Lymphoblastic Leukemia Immunotherapy Treatment: Now, Next, and Beyond
Authors: Aureli Anna , Marziani Beatrice , Venditti Adriano , Sconocchia Tommaso , Sconocchia Giuseppe
Published: May 2023

Acute lymphoblastic leukemia (ALL) is a blood cancer that primarily affects children but also adults. It is due to the malignant proliferation of lymphoid precursor cells that invade the bone marrow and can spread to extramedullary sites. ALL is divided into B cell (85%) and T cell lineages (10 to 15%); rare cases are associated with the natural killer (NK) cell lineage (<1%). To date, the survival rate in children with ALL is excellent while in adults continues to be poor. Despite the therapeutic progress, there are subsets of patients that still have high relapse rates after chemotherapy or hematopoietic stem cell transplantation (HSCT) and an unsatisfactory cure rate. Hence, the identification of more effective and safer therapy choices represents a primary issue. In this review, we will discuss novel therapeutic options including bispecific antibodies, antibody-drug conjugates,chimeric antigen receptor (CAR)-based therapies, and other promising treatments for both pediatric and adult patients.
Genetic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates in a Tertiary Hospital in Greece, 2018-2022
Authors: Zarras Charalampos , Karampatakis Theodoros , Pappa Styliani , Iosifidis Elias , Vagdatli Eleni , Roilides Emmanuel , Papa Anna
Published: May 2023

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious public health issue. Aim of the study was to identify the antimicrobial resistance and accessory genes, the clonal relatedness and the evolution dynamics of selected CRKP isolates recovered in an adult and a pediatric intensive care unit of a tertiary hospital in Greece. Methods: Twenty-four CRKP isolates recovered during 2018-2022 were included in the study. Next-generation sequencing was performed using the Ion Torrent PGM Platform. The identification of the plasmid content, MLST and antimicrobial resistance genes, as well as the comparison of multiple genome alignments and the identification of core genome single-nucleotide polymorphism sites, were performed applying various bioinformatics software. Results: The isolates belonged to eight sequence types 11, 15, 30, 35, 39, 307, 323, and 512. A variety of carbapenemases (KPC, VIM, NDM and OXA-48) and resistance genes were detected. CRKP strains shared visually common genomic regions with the reference strain (NTUH-K2044). ST15, ST323, ST39, and ST11 CRKP isolates presented on average 17, 6, 16 and 866 recombined SNPs, respectively. All isolates belonging to ST15, ST323 and ST39 were classified in distinct phylogenetic branches, while ST11 isolates were assigned to a two-subclade branch. For large CRKP sets, the phylogeny seems to change approximately every seven SNPs. Conclusion: The current study provides insight into the genetic characterization of CRKP isolates in the ICUs of a tertiary hospital. Our results indicate clonal dispersion of ST15, ST323, and ST39 and highly diverged ST11 isolates.
Cognitive Aging in Older Breast Cancer Survivors
Authors: Root James C , Li Yuelin , Schofield Elizabeth , Orlow Irene , Ryan Elizabeth , Traina Tiffany , Patel Sunita , Ahles Tim A
Published: May 2023

Abstract: Background: Cancer and cancer treatments may affect aging processes, altering the trajectory of cognitive aging, but extant studies are limited in interval of assessment (2-5 years). We studied cognitive performance in a cohort of survivors and controls utilizing cross-sectional cognitive performance data from age 60 to 89 years as an indicator of potential aging trajectories and contrasted these trends with longitudinal data collected over two years. Methods: Female breast cancer survivors who had been diagnosed and treated at age 60 or older and were 5– to 15-year survivors (N=328) and non-cancer controls (N=158) were assessed at enrollment and at 8, 16 and 24 months with standard neuropsychological tests and comprehensive geriatric as-sessment. Results: Cross-sectional baseline analysis found the expected inverse association of age with cognition in both groups, with survivors performing lower than controls in learning and memory (LM) but not in attention, processing speed and executive function (APE). Younger survivors, i.e., those under 75 years of age, exhibited early decline in performance in both LM and APE compared to controls, with no differences between older survivors and controls, which tracked with deficit accumulation trends. Conclusion: Differences between survivors and controls were prominent in younger survivors, as was deficit accumulation, suggesting a mediating effect on cognition. Deficit accumulation may represent a modifiable risk factor in cancer survivorship that may be targeted for prevention and intervention.
Stifle joint Arthrodesis for Treating Chronic Osteoarthritis in a Dog
Authors: Lee Shin Ho , Roh Yoon Ho , Lee Dong Bin , Cho Jae-Hyeon , Kim Chung Hui
Published: May 2023

A two-year-old male Pomeranian dog visited the hospital due to side effects of surgical correction for patellar luxation. Stifle joint arthrodesis (SJA) was performed on the patient’s right leg using autologous bone grafting techniques. The right leg’s femur and tibial joint were angled 120-130◦ and the SJA plate was fixed on the front of the two bones. After performing joint fusion of the right limb, medial patellar luxation (MPL)-corrective surgery was performed to cut the tibial tuberosity on the left leg and the fixing force was increased using the figure-of-eight tension band wiring technique. The results were observed for walking and trotting of the right hind limb, evaluated for 27 days after surgery. It was difficult for the patient to walk because weight loading was not performed for 3 days after surgery; short strides and partial weight bearing were possible 5 to 7 days after surgery. After 10 days, the patient was able to move while bearing weight with a slight disruption. For trotting, the patient showed intermittent normal steps 5 to 7 days after surgery, but the disruption continued. After 14 days, trotting was possible and movements were shown to be maintained during everyday activities.
Selective Deposition of Ti on Cyclic Olefin Copolymer Foil by Pulsed Laser Deposition
Authors: Cutroneo Mariapompea , Silipigni Letteria , Mackova Anna , Malinsky Petr , Miksova Romana , Maly Jan , Stofik Marcel , Aubrecht Petr , Fajstavr Dominik , Slepicka Petr , Torrisi Lorenzo
Published: May 2023

Cyclic olefin copolymer (COC) is a novel type of thermoplastic polymer gaining the attention of the scientific community in electronic, optoelectronic, biomedicine and packaging applications. Despite the benefits in the use of COC like undoubted optical transparency, chemical stability, good water-vapor barrier and biocompatibility, its original hydrophobicity restricts its wider applicability and optimization of its performances. Presently, we report on the optical, and morphological properties of the films of COC covered with Ti in selected areas. The layer of Ti on COC was deposited by pulsed lased deposition processing. The Ti/COC film was characterized by UV-Vis spectroscopy indicating that its transmittance in the visible region decreased by about 20% with respect to the pristine polymer. The quality of the deposited Ti was assessed with the morphology by scanning electron (SEM) and atomic force microscopies (AFM). The modification of the wettability was observed by the sessile drop method indicating a reduction of the native hydrophilicity.
Photoluminescent Microbit Inscripion inside Dielectric Crystals by Ultrashort Laser Pulses for Archival Applications
Authors: Kudryashov Sergey , Danilov Pavel , Smirnov Nikita , Kuzmin Evgeny , Rupasov Alexey , Khmelnitskii Roman , Krasin George , Mushkarina Irina , Gorevoy Alexey
Published: May 2023

Inscription of embedded photoluminescent microbits inside a bulk natural diamond, LiF and CaF2 crystals was performed in sub-filamentation (geometrical focusing) regime by 525nm 0.2ps laser pulses focused by 0.65NA micro-objective as a function of pulse energy, exposure and inter-layer separation. The resulting microbits were visualized by 3Dscanning confocal Raman/photoluminescence microscopy as conglomerates of photo-induced quasi-molecular color centers and tested regarding their annealing. Minimal lateral and longitudinal microbit separations, enabling their robust read-out, were measured in LiF as 1.5 and 13 microns, respectively, to be improved regarding information storage capacity by more elaborate focusing systems. These findings pave a way to novel optical storage platforms utilizing ultrashort-pulse laser inscription of photoluminescent microbits as carriers of archival memory.
HISTORICAL RETROSPECTIVE OF THE LEADERSHIP PHENOMENON IN THE CONTEXT OF TRAINING FUTURE SPECIALISTS OF THE STATE EMERGENCY SERVICE OF UKRAINE
Authors: Cherkashyn Andrii
Published: May 2023

Abstract: the article studies the historical retrospective of the phenomenon of leadership by domestic and foreign scientists in the context of training future specialists of the State Emergency Service. It was noted that the formation of leadership in future specialists in higher education institutions with specific training conditions should be based on improving the system of activities of the State Emergency Service of Ukraine, the formation of the necessary educational environment that will contribute to improving the legislative framework, economic mechanisms of civil protection, leadership development and improving the professional training of future specialists of the State Emergency Service of Ukraine.
TO THE QUESTION OF CURRENT TENDENCIES IN ADVANCED TRAINING OF TEACHING STAFF AS A VECTOR OF THEIR PROFESSIONALIZATION
Authors: Grashchenkova Viktoriia , Chudovska Tetiana
Published: May 2023

Abstract: the article is devoted to a detailed analysis of modern trends in the professionalization of teaching staff in the field of advanced training. The necessity of making changes in continuous pedagogical education has been determined. Attention is paid to facilitation of the research and educational process. The question of the formation of the professional identity of teachers is considered. Recommendations are offered for improving  the system of teacher training under the condition of supporting school projects and innovative processes in educational institutions.
La mala autopercepción de salud oral se asocia con la presencia de fragilidad en personas mayores que viven en la comunidad
Authors: Sánchez-García Sergio , Heredia-Ponce Erika , Moreno-Tamayo Karla , Velázquez-Olmedo Laura Bárbara , Cruz-Hervert Pablo , Ramírez-García Eliseo , García-Peña Carmen
Published: May 2023

Objetivo. Determinar la asociación entre mala autopercepción de salud oral y fragilidad en personas mayores. Material y métodos. Estudio transversal en personas mayores de la Ciudad de México. La autopercepción de salud oral se midió con el Geriatric/General Oral Health Assessment Index (GOHAI) y la fragilidad con el fenotipo de Fried y colaboradores. Resultados. 1 173 personas mayores, media de edad de 66.0 (5.7) años, mujeres 46.1% (n=541). La media (IC95%) de GOHAI-Sp fue de 49.2 (48.9-49.6). El 9.2% (n=108) presentaron fragilidad, 59.9% (n=703) prefrágil y 30.9% (n=362) no frágiles. La fuerza de asociación (RM) para mala autopercepción de salud oral y frágil fue RM 2.4 (IC95% 1.5,3.7) y RM ajustada RM 1.7 (IC95% 1.1,2.8), referencia no frágil. No existe asociación significativa para la mala autopercepción de salud oral y prefrágil. Conclusión. La mala autopercepción de salud oral se asocia con la presencia de fragilidad en personas mayores.
Procesos celulares modificados en Aedes aegypti infectados con Wolbachia y la susceptibilidad al virus dengue
Authors: López-Ordóñez Teresa , Díaz-Rodarte Karla Ivonne , Torres-Monzón Jorge Aurelio , Casas-Martínez Mauricio , Danis-Lozano Rogelio , Mosso-González Clemente
Published: May 2023

Objetivo. Analizar la expresión diferencial de proteínas de Aedes aegypti infectados con Wolbachia y su asociación con el ciclo viral del virus dengue (DENV). Material y métodos. Se revisó una base de datos de proteínas de Ae. aegypti infec­tados y no infectados con Wolbachia, cepa wMel y se buscaron estas en revistas indizadas, que hablaran de la proteína y el ciclo viral de DENV. Resultados. La expresión diferencial de proteínas de los mosquitos durante la infección con Wolbachia intervienen en los procesos de entrada, replicación y salida del DENV. Conclusiones. Existen cambios en la expresión de proteínas de células infectadas con Wolbachia, que son necesarias para el ciclo de replicación de DENV, explicando porque algunos mosquitos infectados con Wolbachia son refractarios a la infección por DENV.
Evaluation of commercial aerosol insecticides for control of Aedes aegypti susceptible or resistant to pyrethroids
Authors: López-Solis Alma Delia , Janich Ashley J. , Solis-Santoyo Francisco , Ordóñez-González José Genaro , Fuentes-Maldonado Gabriel , Saavedra-Rodríguez Karla , Villarreal-Treviño Cuauhtémoc , Black IV William C. , Rodríguez Américo D. , Penilla-Navarro Rosa Patricia
Published: May 2023

Objective. To evaluate indoor use of commercial aerosols for dengue vector mosquito control, and estimate the number of treatable houses per can. Materials and methods. Four aerosol products containing combinations of pyrethroids (two containing propoxur and one containing synergists too), were evaluated with mosquitoes in a room of a Tapachulastyle house. Eight cages containing 20 insecticide susceptible or resistant females were hung from tripods, another set was placed in sheltered areas of the room. From the entrance of the room, one of 4-9 concentrations was sprayed for each aerosol, leaving the mosquitoes for 30 min after sprayed. Mortality was recorded after 24 h and lethal concentrations were calculated. Results. Aerosol A had the highest LC50, with 0.308 g for mosquitoes hanging from tripods and 0.453 g for sheltered mosquitoes; followed by aerosols C, D and B, with statistical differences between types of exposure. Conclusions. Aerosols B-D could spray 20-25 3-room houses (56 m3-room), killing all resistant mosquitoes. Aerosols may become a good tool for indoor mosquito control, if the optimal concentration and correct spray method are used.
Breaking Solvation Dominance of EC via Electron Engineering Enables Battery Operation Below -100℃
Authors: Chen Yuqing , He Qiu , Zhao Yun , ZHOU WANG , Xiao Peitao , Gao Peng , Tavajohi Naser , Tu Jian , Li Baohua , He Xiangming , Xing Lidan , Fan Xiulin , Liu Jilei
Published: May 2023

The performance of current lithium-ion batteries (LIBs) is severely impaired by low temperatures, which require the development of powerful electrolytes with widen liquidity, facilitated ion diffusion ability, and lower desolvation energy. The keys lie in establishing mild interactions between Li+ and solvent molecules internally, which is hard to realize in commercial ethylene carbonate (EC) based electrolytes due to the strong coordination of EC to Li+. To address this challenge, we tailored the solvation structure with low-ε solvent dominated coordination and unlocked EC via electronegativity regulation of carbonyl oxygen. The modified electrolytes retain considerable ion conductivity (1.46 mS/cm) at -90 ℃, remain liquid at -110℃, and facilitate Li+ desolvation. Consequently, 4.5V graphite-based pouch cells perform stably with ~98% capacity retention and no lithium dendrite formation over 200 cycles at -10 ℃. These cells also retain ~60% of their room-temperature discharge capacity at -70 ℃, and miraculously remain functional even below -100 ℃. This design strategy of breaking the solvation dominance of EC via electron engineering can be extended to other alkali-metal-ion batteries at extremely low temperature.
The effects of the inclusion of jabuticaba peel flour on performance, metabolism, and its influence on the skin color of Carassius auratus
Authors: SOUSA Rebeca Maria , Siqueira Mayara Schueroff , SCARDUA Marcos Paiva , PINHO Tainá Avila , CASARI Andressa C.A.B. , DEBOLETO Sandriele G.C. , NEU Dacley Hertes , HONORATO Claucia Aparecida
Published: May 2023

This work aimed to evaluate the inclusion of jabuticaba peel flour (JPF) in skin color and productive performance, biochemical, blood, and enzymatic parameters of Carassius auratus. 72 fish (weight 9.67 ± 0.37 g, length 7.38 ± 0.18 cm) were distributed into four treatments (0.00; 1.00; 1.50 and 2.00% JPF), in a completely randomized design with three replications with six fish per box. After 60 days, to evaluate the performance of the fish. To assess the skin color of the fish, a portable photo colorimeter was used using the Hunter coordinate system, where the coordinates of L*, a*, and b*. Blood samples were taken for biochemical analysis regarding glucose, triglycerides, and cholesterol. The analysis of ALT and AST, albumin and triglycerides in liver tissue, and amylase, lipase, nonspecific protease, and alkaline phosphatase in the intestine. Results obtained showed that there was a significant difference about feed intake and specific growth rate with the inclusion of JPF. It was observed that fish fed with 1.00 and 1.50% JPF obtained an increase in brightness represented by the L coordinate and shades of yellow represented by the b coordinate. Glucose increased with 2.00% of JPF. AST activity was higher with 1.00% JPF and ALT was reduced with the inclusion of JPF, demonstrating an ability to protect against possible liver damage. The inclusion of JPF is effective at levels of up to 1.5% to increase the brightness of the skin of Carassius auratus.
Development and Validation of Epigenetic Modification-Related Signals for the Diagnosis and Prognosis of Colorectal Cancer
Authors: Li Xia , Li Jingjing , Li Jie , Liu Nannan , Zhuang Liwei
Published: May 2023

Backgroud Colorectal cancer (CRC) is one of the world's most common malignancies. Epigenetics is the study of heritable changes in characteristics beyond the DNA sequence. Epigenetic information is essential for maintaining specific expression patterns of genes and the normal development of individuals, and disorders of epigenetic modifications may alter the expression of oncogenes and tumor suppressor genes and affect the development of cancer. This study elucidates the relationship between epigenetics and the prognosis of CRC patients by developing a predictive model to explore the potential value of epigenetics in the treatment of CRC.Methods Gene expression data of CRC patients’ tumor tissue and controls were downloaded from GEO database. Combined with the 720 epigenetic-related genes (ERGs) downloaded from EpiFactors database, prognosis-related epigenetic genes were selected by univariate cox and LASSO analyses. The Kaplan–Meier and ROC curve were used to analyze the accuracy of the model. Data of 238 CRC samples with survival data downloaded from the GSE17538 were used for validation. Finally, the risk model is combined with the clinical characteristics of CRC patients to perform univariate and multivariate cox regression analysis to obtain independent risk factors and draw nomogram. Then we evaluated the accuracy of its prediction by calibration curves.Results A total of 2906 differentially expressed genes (DEGs) were identified between CRC and control samples. After overlapping DEGs with 720 ERGs, 56 epigenetic-related DEGs (DEERGs) were identified. Combining univariate and LASSO regression analysis, the 8 epigenetic-related genes-based risk score model of CRC was established. The ROC curves and survival difference of high and low risk groups revealed the good performance of the risk score model based on prognostic biomarkers in both training and validation sets. A nomogram with good performance to predict the survival of CRC patients were established based on age, NM stage and risk score. The calibration curves showed that the prognostic model had good predictive performance.Conclusion In this study, an epigenetically relevant 8-gene signature was constructed that can effectively predict the prognosis of CRC patients and provide potential directions for targeted therapies for CRC.
The synergistic effect of TGM2 and TGFβ2 on the prognosis of colon cancer patients
Authors: Shi Lei , Wang¹ Yue , Cheng¹ Zhihua , Lv¹ Zhe , Lu Ri-feng , Gao Hai-cheng
Published: May 2023

Colon cancer (CNC) ranks third in incidence and second in mortality among all cancers worldwide. Unfortunately, the available treatment options for CNC have limited effectiveness in improving patients' prognosis, and the pathogenesis of CNC remains poorly understood. Transglutaminase 2 (TGM2) and TGF-β2 both play a positive role in regulating cancer progression, promoting tumor progression and metastasis. However, the mutual relationship between TGM2 and TGF-β2 has not been well studied. Our analysis of transcriptome data from CNC patients on the TCGA website showed that the expression levels of TGF-β2 and TGM2 were related to TNM staging and tumor size (P < 0.05), and high expression of TGF-β2 and TGM2 was associated with a worse prognosis (P < 0.05). To validate these findings, we performed experiments using collected tumor tissue specimens from CNC patients, which demonstrated that inhibiting TGM2 could reduce the expression of TGF-β2 and improve the prognosis of CNC patients. Therefore, targeting TGM2 and TGF-β2 may become feasible therapeutic targets for CNC, and our study has provided directions for the development of CNC treatment drugs.
Active versus Passive physiotherapy for chronic shoulder pain: a systematic review and meta-analysis
Authors: Wang Ruirui , Wang Jialin , zhao peng , Zhao Xiao , Zhou Xuanhui Guo
Published: May 2023

Objective To explore the effects of active physiotherapy (AP) and passive physiotherapy (PP) on pain intensity and function in patients with chronic shoulder pain.Design Systematic review and meta-analysis.Methods Two independent researchers searched PubMed, Cochrane library, Embase, Web of science, CINAHL and PEDro from the beginning to September 7, 2022. All included studies were evaluated for risk of bias by the Cochrane risk-of-bias tool and the certainty of results was rated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.Eligibility criteria Randomized controlled trials (RCTs) involving patients with chronic shoulder pain were included. The treatment must be AP versus PP.Results Altogether 21 studies, including 1011 patients, were included. The primary result: Compared with passive manipulation, AP was superior in the pressure pain threshold (PPT) of shoulder (SMD-0.09, 95%CI: -0.42 to 0.24, P = 0.59), pain intensity (SMD-0.37, 95%CI: -0.71 to -0.03, P = 0.03) and function (SMD-0.22, 95%CI: -0.43 to -0.01, P = 0.04). AP had an advantage over physical factor therapy in terms of pain intensity (SMD-1.32, 95%CI: -2.34 to -0.29, P = 0.01) and function (SMD-0.64, 95%CI: -1.15 to -0.14, P = 0.01). The secondary result: AP was superior to PP at short-term and medium-term follow-up, with no difference at long-term follow-up.Conclusions Evidence with moderate to very low certainty suggests AP was superior to PP in pain and functional improvement in patients with chronic shoulder pain at short-term and medium-term follow-up, but this advantage was not observed in the long-term follow-up.
What is the impact of ITGβ8 on NSCLC: A systematic study
Authors: Jin Zhao , Jiao Zonglin , Song Lei , Wang Haitao , Zhang Yu , Zhao Yanbin , Zhang Minghui
Published: May 2023

Background: Integrin is a vital cell membrane surface receptor that conducts bidirectional signal transduction across the cell membrane and regulates cell adhesion and activation. Integrin β8 (ITGβ8) belongs to the β subunit family of integrin. It is a tumour promoter and its levels are upregulated in various cancers, including non-small-cell lung cancer (NSCLC). However, a comprehensive analysis of its prognostic value in NSCLC has not been performed. Here, bioinformatics analysis and basic experiments were used to investigated the expression of ITGβ8 in NSCLC and its potential association with immunotherapy.
Methods: In this study, we used bioinformatics technology to analyze not only the expression of ITGβ8 in NSCLC tissues in the database, but also the correlation between ITGβ8 expression and immune cell infiltration, immune checkpoint expression, TMB expression, signaling pathways and patient survival. The expression of ITGβ 8 in NSCLC cells was verified by WB and RT-qPCR. Kaplan-Meier survival curves were used to analyze the relationship between ITGβ8 expression levels and prognosis of NSCLC patients. Log-rank test and cox proportional-hazards model were used to identify risk factors associated with prognosis.
Results:The TCGA database and HPA database as well as our lung cancer tissue specimens showed high expression of ITGβ8 in NSCLC tumor tissues. ITGβ8 was highly expressed in lung cancer cell lines compared to normal lung epithelial cell lines. Bioinformatics technology analysis demonstrated that ITGβ8 expression correlated with immune subtypes, immune infiltrating cells, immune checkpoint genes, and signaling pathways. High expression of ITGβ8 in NSCLC has a shorter survival. Kaplan-Meier survival curve and cox regression analysis demonstrated that increased ITGβ8 expression was a marker of poor prognosis in NSCLC, and its expression level was positively correlated with lymph node metastasis and TNM stage.
Conclusions: ITGβ8 is highly expressed in NSCLC, and it is involved in regulating the immune process of NSCLC. It may be an important immune predictive biomarker that provides a new idea for the treatment of NSCLC.