bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the effectiveness of platelet-rich plasma therapy in the treatment of osteoarthritis compared to other treatment methods
Authors: Makarewicz Magdalena , Łysiak Anna , Łysiak Katarzyna , Maziarz Barbara
Published: January 2025

Introduction and objective: Osteoarthritis is a common condition affecting a large proportion of the population. It is associated with a significant reduction in quality of life due to pain and limited joint mobility. There are many methods of treatment, among them conservative methods, pharmacological or surgical treatment can be mentioned. This article analyzes the effectiveness of intra-articular injections of platelet-rich plasma compared to other methods.
The aim of the article is to characterize the disease which is osteoarthritis, draw attention to its etiology, diagnostic and especially to therapeutic possibilities.
Materials and methods: The article was based on scientific publications in the Pubmed database. The database was searched on  July 28 2023 using the phrases 'osteoarthritis', ‘PRP’, ‘Platelet-rich plasma’. After reading the titles of found articles, 39 publications were selected. After the pre-analysis of the abstracts, 15 full-text works were selected to prepare the article.
Abbreviated description of the state of knowledge: Platelet-rich plasma is widely used in the treatment of osteoarthritis. There are many sources that prove its effectiveness in reducing pain, compared to injections of other substances, but there are also studies about the lack of sufficient evidence or the effect of prp similar to the placebo effect.
Summary: The use of platelet-rich plasma is a promising method of treating osteoarthritis, however, further research and long-term observations are needed to introduce this method to the standards of treatment.
Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus x microcarpa Bunge peels and leaves essential oils
Authors: Husni Elidahanum , Hamidi Dachriyanus , Pavvellin Dean , Hidayah Hafizatul , Syafri Suryati
Published: January 2025

Wound care is still dominated by the use of synthetic chemicals such as anti-inflammatory drugs, corticosteroids and antibiotics which have many shortcomings. One potential alternative  to be developed is essential oils. Citrus are members of the Rutaceae family which contain essential oils. Citrus medica L. and Citrus x microcarpa Bunge are distributed in West Sumatra and research on wound healing activity is still lacking. Therefore, this study aims to identify the metabolite profiles of essential oils of two species of citrus using FTIR spectroscopy and GC-MS as well as evaluate their antioxidant activity and determine their wound healing activity. Essential oils were obtained by the hydrodistillation method. Metabolite fingerprinting and profiling were carried out by using FTIR and GC-MS methods. Antioxidant activity was determined using the ABTS and FRAP methods while wound healing used the MTT Assay and Scratch Assay. The result showed the secondary metabolites of Citrus medica peels (LPEO) and Citrus medica leaves (LLEO) essential oil contained D-limonene and citral. Meanwhile Citrus x microcarpa leaves (MLEO) contain β-pinene, germacrene D, and elemol and Citrus x microcarpa peels essential oil (MPEO) consists of D-limonene, β-pinene, and germacrene D. MLEO has stronger antioxidant activity than MPEO, LPEO and LPEO with ABTS and FRAP method with IC50 197.051 µg/mL and 8.04 Fe (II)/mg sample and is followed by LLEO. Testing of wound healing activity using MTT assay showed that MPEO significantly increased cell proliferation. Meanwhile, the highest wound closure was found at a concentration of 0.1 µg/mL for MLEO followed by LPEO at 77.54% and 73.71% using scratch assay method. It can be concluded that essential oils of Citrus medica and Citrus x microcarpa can increase cell proliferation and migration so that they have potential to be developed as an alternative in wound healing.
The effect of ethyl acetate fraction of Vernonia amygdalina Del. leaves on uric acid levels of male white mice (Mus musculus) hyperuricemia
Authors: Azzahra Rafifah , Arifin Helmi , Juwita Dian Ayu
Published: January 2025

Hyperuricemia is a condition where uric acid levels in the blood are increased above normal. High levels of uric acid in the blood can cause a buildup of uric acid crystals in the joints and other organs of the body. One of the plants used as traditional medicine to reduce uric acid levels in the blood is Vernonia amygdalina Del. plant. This study aims to determine the effect of ethyl acetate fraction of V. amygdalina on uric acid levels of hyperuricemic male white mice. The experimental animals used were 54 male white mice which were divided into 6 groups, namely the negative control group, the positive control group, the comparison group, the 12.5 mg/kgBW dose treatment group, the 25 mg/kgBW treatment group, and the 50 mg/kgBW doses treatment group with a treatment duration of 5 days, 10 days and 15 days. Data analysis used two-way analysis of variance (ANOVA) followed by Duncan's Post Hoc test with 95% confidence intervals (P<0.05). The results obtained showed that uric acid levels decreased along with the length of time the ethyl acetate fraction was administered with the optimal reduction effect at a dose of 50 mg/kgBW. This study shows that the ethyl acetate fraction of V. amygdalina exhibits antihyperuricemic activity and can be used as an alternative medicine in the community.
Molecular docking, bioactivity, adme, toxicity risks, and quantum mechanical parameters of some 1,2-dihydroquinoline derivatives were calculated theoretically for investigation of its use as a pharmaceutical active ingredient in the treatment of multiple sclerosis (MS)
Authors: Islamoğlu Fatih
Published: January 2025

In this study, some 1,2-dihydroquinoline derivatives, which have not been synthesized before, were designed, and their usability in the treatment of multiple sclerosis (MS) was investigated. Firstly, a docking study was conducted between the designed molecules and the target proteins (3PP4, 6OBD, 7YXA, and 7TD4) that interact with drugs (International Nonproprietary Name (INN): Ocrelizumab, Alemtuzumab, and Siponimod) used in the treatment of MS. ADME (absorption, distribution, metabolism, and excretion) properties (Boiled Egg graph, bioavailability radar, physicochemical properties, lipophilicity, water solubility, pharmacokinetics, drug similarity, and medicinal chemistry) were analyzed. Bioactivity score, drug-likeness score, drug score, toxicity risks (mutagenic, tumorigenic, irritant, reproductive effective, fathead minnow LC50 (96 hours), daphnia magna LC50 (48 hours), oral rat LD50), bioconcentration factor, and density values were calculated. Quantum mechanical parameters include highest occupied molecular orbital energy (EHOMO), lowest unoccupied molecular orbital energy (ELUMO), chemical potential (μ), electron affinity (EA), global softness (S), global hardness (η), ionization potential (IP), total energy, dipole moments, and electrophilicity (ω) values were also calculated for all molecules. As a result of the data obtained from all these studies, (7-(diethylamino)-1,2-dihydroquinolin-3-yl)(6-(diethylamino)-2,3-dihydro-1H-indazol-1-yl)methanone was determined to be the most ideal molecule that can be used as a pharmaceutical active ingredient in the treatment of MS. Bond angles, bond lengths, Mulliken atomic charges, and molecular electrostatic potential (MEP) were calculated for this ideal molecule, and the structure of the molecule was explained in a multifaceted way.
Lycium barbarum polysaccharide fraction – isolation from fruits and impact on the secretion of inflammatory mediators by human mononuclear cells and neutrophils
Authors: Kuśnierek Marta , Czerwińska Monika
Published: January 2025

The barbary wolfberry fruit (Lycium barbarum L.) has been used in traditional Chinese medicine for centuries as an anti-aging, anti-fatigue, immune-supporting, and soothing agent for many age-related, mainly metabolic, oxidative, and inflammatory diseases. The purpose of the study was to demonstrate potential properties supporting the work of the immune system of the Lycium barbarum polysaccharides (LBP) fraction by studying their effect on the secretion of cytokines or chemokines by human peripheral blood mononuclear cells (PBMC) and neutrophils (PMN). The impact of LBP (5-100 µg/mL) on the secretion of cytokines or chemokines (IL-6, IL-10, TNF-α, IL-1β, IL-8) by PBMC and PMN was tested by enzyme-linked immunosorbent assay (ELISA). The potential cytotoxicity of LBP was determined by staining with propidium iodide (PI) with flow cytometry. The tested fraction did not show a significant influence on IL-10 and IL-8 secretion by PBMC and PMN, respectively. However, LBP at the highest concentration stimulated PBMC to increase the production of IL-6 and TNF-α. The highest efficiency of LBP was shown against the secretion of TNF-α and IL-1β by PMN.
Nie tylko folie i opakowania. Część 1: O zastosowaniach polimerów w okulistyce, stomatologii i sprzęcie medycznym.
Authors: Warguła Joanna
Published: January 2025

Polimery stanowią zróżnicowaną grupę chemiczną, bowiem w ich strukturach odnaleźć można cały wahlarz ugrupowań chemicznych, np. układy aromatyczne (np. polistyren), podstawniki halogenowe (np. polichlorek winylu), wiązania estrowe (np. dakron) czy też amidowe (np. polikaprolaktam). Ta różnorodność chemiczna przekłada się na szerokie spektrum właściwości fizykochemicznych (np. zdolność pochłaniania wody, twardość, plastyczność), a co za tym idzie na aplikacyjność polimerów, w tym w naukach medycznych I farmaceutycznych. W niniejszym doniesieniu przedstawiono przykłady polimerów stosowanych w okulistyce, stomatologii i szeroko rozumianym sprzęcie medycznym. Szczególny nacisk położono na przedstawienie cech warunkujących konkretne zastosowanie.
The therapeutic potential of mesenchymal stromal cells and their secretome in sport-related injuries
Authors: MOBAYED Nour , Joujeh Dima
Published: January 2025

As the prevalence of sports-related injuries continues to rise, there is an urgent need for innovative therapeutic strategies that not only expedite recovery but also enhance the quality of healing. The application of mesenchymal stromal cells (MSCs) therapy in the treatment of sports injuries represents a groundbreaking advancement in the field of regenerative medicine. This review aims to summarize and discuss the therapeutic effects of MSCs in facilitating tissue regeneration and expediting the healing process following sports-related injuries. It also aims to highlight current research findings regarding the efficacy, safety and administration routes in clinical MSCs therapy trials. Data was obtained by searching Pubmed and Google Scholar, using the keywords: ‘sport injury, ‘Osteoarthritis’, ‘mesenchymal stromal/stem cells’, ‘tendon’, ‘cartilage defect’, ‘ligament injury’, ‘MSC secretome’, ‘conditioned medium’. According to the U. S. National Library of Medicine, there have been a total of 7,146 registered clinical trials worldwide on stem cell therapy till 5/10/2024, with 1,626 specifically focusing on MSCs therapy. The safety and efficacy of MSCs and MSCs secretome therapies in treating sport-related injuries have been shown in many preclinical studies. The promising outcomes observed in experimental studies have propelled the transition to clinical trials, which have also shown positive results. MSCs therapy has the potential to accelerate healing processes, reduce downtime, and allow athletes to return to their sport faster and with greater confidence. This is crucial not only for professional athletes but also for recreational sports enthusiasts who seek to maintain an active lifestyle. However, bone marrow mesenchymal stromal cells (BM-MSCs), umbilical cord mesenchymal stromal cells (UCB-MSCs) and adipose-derived mesenchymal stromal cells (AD-MSCs) were predominantly utilized in these trials, indicating that there is unexplored therapeutic potential of MSCs from other sources. This review not only aims to contribute valuable knowledge to the field, but also aspires to inspire further exploration and innovation in the use of MSCs for enhancing athletic performance and recovery.
Anti-cancer activity of phenyl-1,3,5-heptatriyne in human liver cancer
Authors: Faridi Uzma
Published: January 2025

Bidens pilosa, commonly known as Ottrancedi, is a medicinal plant from the ancient period. It contains polyacetylenes, flavonoids, terpenoids, phenylpropanoids, which are well known molecules present in high concentration in medicinal plants with many antibacterial, antifungal and anticancer properties. To study the detailed mode of action of phenyl-1,3,5-heptatriyne which showed promising results on human liver cancer cell line HepG-2, we performed many assays like DNA fragmentation assay, Caspase-3 assay, Cell cycle analysis and fluorescent microscopic studies. During over studies we found that the molecule causes apoptosis in cancer cells lines by expressing high amount of Caspase-3 enzyme and it arrests the cells in G2/M phase. As it is already reported that the infusion of B. pilosa L. is non-toxic for single and repeated dose also for dermal structures so the molecule phenyl-1,3,5-heptatriyne can be a good candidate for a anticancer drug in future.
General properties, biosynthesis, pharmacological properties, biological activities and daily uses of luteolin
Authors: Yazar Memet , Sevindik Mustafa , Polat Abdullah Ozan , Koçer Oğuzhan , Kuşçu Karatepe Hilal , Uysal İmran
Published: January 2025

Phenolic molecules are secondary metabolites that facilitate several biological processes. Secondary metabolites are non-nutritive substances that hold significant medicinal value. Our study combined the biological activities, general features, daily usage conditions, and biosynthesis of luteolin as reported in the literature. The literature review revealed that luteolin exhibits biological activities including antioxidant, antibacterial, anticancer, and anti-inflammatory properties. It was observed that it exerts effects on illnesses including cardioprotection, cholesterol regulation, neuroprotection, autistic spectrum disorders, gastrointestinal issues, obesity, insulin sensitivity, anxiety/depression, and arthritis. In this regard, luteolin was identified as a significant molecule for pharmacological applications.
Phytochemical profile and physicochemical analysis of the leaves of Ziziphus mauritiana
Authors: Jha Deepak , Parihar Ashish Singh
Published: January 2025

Ziziphus mauritiana Lam. (Indian jujube) is traditionally used to treat asthma, digestive disorders, skin conditions, and ulcers. Despite its wide medicinal applications, comprehensive phytochemical and physicochemical profiling of Z. mauritiana leaves remains limited. The current study aimed to establish a detailed phytochemical and physicochemical profile of Z. mauritiana leaves across different solvent extracts to aid in standardization and quality control. Fresh Z. mauritiana leaves were collected, authenticated, dried, and powdered. Soxhlet extraction was performed using seven solvents: acetone, water, chloroform, dichloromethane, ethanol, ethyl acetate, and petroleum ether. Physicochemical analyses included ash content, extractive values, moisture content, and pH. Qualitative phytochemical screening was conducted to identify bioactive compounds such as carbohydrates, proteins, flavonoids, tannins, and alkaloids. Physicochemical analysis revealed total ash (7.5%), acid-insoluble ash (2.5%), and moisture content (7.3%). Extractive values varied across solvents, with ethyl acetate showing the highest yield (0.76%). Phytochemical screening demonstrated the presence of carbohydrates, proteins, amino acids, steroids, flavonoids, phenolic compounds, tannins, glycosides, and alkaloids, with variation across solvents. Z. mauritiana leaves exhibit a diverse range of bioactive compounds with potential antioxidant, anti-inflammatory, and antimicrobial activities, supporting their traditional medicinal use. Future research should focus on quantifying these compounds using advanced analytical methods and exploring other plant parts for a comprehensive profile.
Analisis Akuntabilitas Pengelolaan Dana Desa di Desa Buntu Babang
Authors: Dasila Rifqa Ayu
Published: January 2025

Akuntabilitas menjadi kunci utama dalam memastikan efektivitas pengelolaan dana desa. Prinsip ini menuntut adanya transparansi, partisipasi masyarakat, dan kepatuhan terhadap regulasi dalam setiap tahapan pengelolaan keuangan desa, Tanpa akuntabilitas yang baik, program dana desa berpotensi tidak mencapai sasaran dan rentan terhadap praktik-praktik yang menyimpang. Tujuan dilakukannya penelitian ini adalah untuk menganalisis bagaimana akuntabilitas pengelolaan Dana Desa di Desa Buntu Babang. Data yang digunakan dalam penelitian ini adalah data primer yang diperoleh melalui observasi, wawancara dan dokumen. Metode analisis data yang digunakan adalah kualitatif, dengan hasil penelitian disajikan dalam bentuk narasi deskriptif. Narasumber dalam penelitian ini adalah para pemangku kepentingan seperti Kepala Desa, Ketua BPD, Sekertaris Desa, Bendahara Desa, Kaur Pembangunan dan Perwakilan Masyarakat. Hasil penelitian menunjukkan bahwa Akuntanbilitas Pengelolaan Dana Desa di Buntu Babang yang mulai dari Tahap Perencanaan, Tahap Pelaksanaan, Tahap penatausahaan, Tahap pelaporan dan Pertanggungjawaban telah menerapkan prinsip partisipatif, transparansi dan kepatuhan yang sesuai dengan prinsip-prinsip dasar tata kelola keuangan desa.
Configurações da modernidade em Terra sonâmbula, de Mia Couto
Authors: Sousa Rayniere Felipe Alvarenga de , Morais Maria Perla Araújo
Published: January 2025

Este artigo objetiva analisar as configurações da modernidade no romance Terra sonâmbula (2007), de Mia Couto. Por modernidade entendemos um conjunto de processos que agrupam atitudes ligadas ao contexto histórico, político e social de países na condição de colonizadores e de colonizados, estando em evidência a realidade moçambicana reconstituída, esteticamente, por Mia Couto. Nesse caso, percebemos a manifestação das colonialidades instituídas pelo controle das narrativas, bem como as tentativas de interrupção no círculo disposto. Para o alcance da substância teórica do estudo, recorremos às leituras de Octavio Paz (1984), Michel Foucault (1987), Walter Benjamin (1989; 1936), Anthony Giddens (1991), Anatol Rosenfeld (1996) e Susan Sontag (2008). Com Nelson Maldonado-Torres (2018), expandiremos o debate conceitual para a modernidade/colonialidade e a decolonialidade – concepção necessária para o entendimento da colonialidade em territórios subjugados pelos processos de exploração e de controle do Ocidente. Terra sonâmbula apresenta a trajetória de personagens marcados pelas questões do período de guerras experienciado em Moçambique, dos quais destacamos a Guerra de Independência de Moçambique (1964 – 1974) e a Guerra Civil Moçambicana (1977 – 1992). Sendo capaz de perceber a modernidade pelo viés duplo, tanto como tema, quanto como traço estrutural: as narrativas atravessadas dos narradores, as guerras de libertação, o padecimento dos moçambicanos, a imbricação de diferentes formas de constituição discursiva (como a introdução dos cadernos de Kindzu) e a resistência à colonialidade são resultados obtidos por intermédio das reflexões aqui desenvolvidas.
Um “bordado oculto”:
Authors: Gallo Fernanda Bianca Gonçalves
Published: January 2025

Levando em consideração o oceano Índico enquanto uma “arena inter-regional de interação política, econômica e cultural” (Bose, 1998, p.26) na qual, desde o século VII, os processos de islamização contribuíram para a disseminação de diferentes formas de literacia no continente africano, este texto revisita criticamente a periodização literária comumente utilizada na área das Literaturas Africanas de Língua Portuguesa, defendendo sua ampliação a partir das contribuições levantadas, sobretudo, por Isabel Hofmeyr (2018); Chapane Mutia e Clarisse Vierke (2020, 2022) e Lizzat Bonate (2016) no que se refere ao papel do Islã nos circuitos de escrita e na produção literária.
Da Cosmopercepção ao Mulherismo:
Authors: Freitas Sávio Roberto Fonsêca de
Published: January 2025

Nossa proposta  é desenvolver uma análise do livro Cães à estrada e poetas à morgue (2022), da escritora moçambicana Deusa d’África. Para fundamentar nossas reflexões sobre o referido corpus,  vamos nos ancorar nos posicionamentos críticos de Paulina Chiziane (2013) sobre escrita moçambicana de autoria feminina, de Clenora Hudson-Weems (2020) sobre mulherismo Africana e de  Oyeronké Oyewumi (2021) sobre cosmopercepção. A poesia da escritora moçambicana Deusa D’África mostra um exercício continuum do projeto de moçambicanidade a partir de um discurso que se organiza no feminino no sentido de territorializar uma produção literária, que fora de Maputo, ecoa ao ritmo do xitende e dissemina um mulherismo afro-moçambicano cuja agenda de discussão se volta para a condição da mulher. Para o desenvolvimento da discussão, vamos nos ater à análise dos poemas “A língua da mulher”, “A costureira” e “Querida Disney”.
O útero da casa:
Authors: Palmeira Naduska Mário
Published: January 2025

A partir da obra O útero da casa, de Conceição Lima, poeta são-tomense, é possível observar o início de um projeto poético de reconstrução individual, coletivo, nacional, que perpassa, como uma obsessão, toda a obra, e cresce em desejo a cada verso. No seio (ou no útero) da casa, pode-se habitar uma sala que metaforiza a luta, a praça, pode-se locomover pela obra, sem obstáculos, no caminho plano e redondo. No entanto, tal casa é, também e ainda, sonhada, alta, sagrada, narrada fio a fio e, como poderia se esperar, inacabada – “Sonho ainda o pilar - / uma rectidão de torre, de altar/(...)/ E reinvento em cada rosto fio/a fio/as linhas inacabadas do projecto” (idem, p. 20, grifos meus). O que Conceição Lima realiza em sua obra parece-me uma trajetória inovadora para o contexto das artes literárias de São Tomé e Príncipe. Ela busca projetar, no versejar, no chão da linguagem, a terra sonhada de São Tomé e Príncipe como buscasse re-encontrar a própria Casa. Ou defrontar-se com a sua própria identidade e afetividade. Essa trajetória pode ser fruto de uma moldura histórica – que impulsionou os intelectuais das ex-colônias ao exílio (ainda que não tenha sido “forçado”, no caso da poeta) – e, de uma perspectiva ontológica – que impõe ao sujeito o ofício de permanecer e, ao mesmo tempo, partir de sua terra originária.
Memória dos mortos:
Authors: Rodrigues Edimilson
Published: January 2025

O percurso de leitura ocorre através de sintéticos excertos que tangenciam a morte. Os textos selecionados, como o sudário, envolvem memórias, histórias, atrocidades em configurações variadas sobre a morte – real e comovida – em imagens evocadoras de escarificações coloniais. São variações em torno da morte, das lides sociais, que apresentam o texto literário como essência de vida perpetuada em arte.
Museu da Revolução, de João Paulo Borges Coelho:
Authors: Almeida Tarik Mateus de
Published: January 2025

A partir de debates conceituais em torno das recentes cartografias culturais que compõem a área das Literaturas Africanas, este artigo busca abordar possíveis enquadramentos teóricos à luz de compreender as formas narrativas abarcadas pelo romance “Museu da Revolução” (2022), de João Paulo Borges Coelho. Tendo em vista, a necessidade de se buscar outras e novas “DecliNações” (Falconi, 2021) para o estudo das Literaturas Africanas de língua portuguesa, mapeamos as recentes reflexões teóricas entorno da Literatura Comparada, discutindo o conjunto estético que “Museu da Revolução” abriga em sua estrutura. O artigo demonstra como as formas narrativas na obra se articulam a partir da dimensão “mundana” do romance em seu caráter (ir)realista, costeiro e ecocrítico, que aponta sobretudo à multiplicidade das formas de narrar o passado moçambicano por meio de estratégias discurssivas que ampliam as noções de história e ficção, por um lado, e, por outro, na convivência artística entre materialidades humanas e não-humanas. Nesse sentido, este artigo se orienta por itinerários críticos e conceituais oriundos do campo da Literatura-Mundial (world-literature), de WReC (2020); dos Estudos do Oceano Índico (Indian Ocean Studies); e também do campo das Humanidades Ambientais, Ecocrítica, na tentativa de compreender a complexidade da identidade narrativa que abarca a obra “Museu da Revolução”.
Impact of COVID-19 on Maternal and Neonatal Outcomes
Authors: Shaimerdenova Gulbanu Ganikyzy , Abuova Gulzhan Narkenovna , Ayazbekov Ardak , Taskynova Gulzhaukhar , Bekaryssova Dana
Published: January 2025

Background: The coronavirus (COVID-19) pandemic has caused global uncertainty. Recent studies indicate an increased risk of spontaneous abortion, spontaneous preterm labor, and severe maternal and neonatal complications caused by COVID-19. Objectives: The aim of our study is to investigate the impact of COVID-19 infection on maternal and neonatal perinatal outcomes. Methods: This is a non-interventional, analytical clinical study. We conducted a retrospective analysis of 410 histories of pregnant women admitted to hospitals from 2020 to 2022 in the City Infectious Disease Centre and the City Infectious Disease Hospital of Shymkent. Results: In the main group, there were 48 (21.0%) babies, while in the control group, there were 18 (10.5%) babies. A weight above 2500 g was recorded in 79% (182) of newborns in the main group. When comparing the weight of newborns between the groups, we did not find statistically significant differences (P = 0.051). Births of babies weighing more than 2500 g were 2.26 times more common in the control group than in the main group (95% CI: 0.984 - 5.228). A birth height of less than 48 cm was recorded in 1.7% (3) cases in the control group and 13.8% (32) of newborns in the main group (P = 0.002). A birth height greater than 48 cm was recorded in 86.2% (198) of neonates in the main group and 98.3% (84) in the control group. Conclusions: A large systematic review (28 studies involving 790,954 pregnant women, among whom 15,524 were diagnosed with SARS-CoV-2 infection) aimed to investigate the relationship between SARS-CoV-2 infection during pregnancy and the risk of pre-eclampsia. It should also be noted that SARS-CoV-2 during pregnancy increases the likelihood of developing severe pre-eclampsia and HELLP syndrome. In our study, preeclampsia (54 - 13.1%) and HELLP syndrome (4 - 1.1%) were more frequent in the main group than in the comparison group. It should also be noted that frequent complications of COVID-19 in pregnant women included preterm labor (80 - 19.4%) and antenatal fetal death (8 - 2.0%). Analysis of perinatal outcomes revealed that women with COVID-19 infection are significantly more likely to give birth to infants with low growth, prematurity, and lower Apgar scores, and these infants are more likely to stay in the neonatal pathology department compared to those born to women without COVID-19 infection.
Spotlight on Qatar 2025
Authors: Gonchigdorj Ariunkhishig , Green Crystal
Published: January 2025

This report, Spotlight: Qatar 2025, conducted by HundrED in partnership with Qatar Foundation, highlights impactful and scalable educational innovations within Qatar's education system. The study aligns with Qatar National Vision 2030, emphasizing the transition to a knowledge-based economy through advancements in education. The selected innovations focus on key areas such as STEM education, Arabic language and cultural preservation, digital literacy, and sustainability, addressing critical challenges like student engagement, teacher development, and inclusivity.

Through an in-depth review process, ten innovative projects were chosen, demonstrating diverse approaches to modern pedagogical challenges. These include integrating VR/AR technologies in STEM, fostering Arabic language skills through interactive programs, and promoting sustainability through hands-on student projects. Collectively, these initiatives exemplify Qatar's commitment to preparing students for global challenges while preserving cultural heritage.

The report provides insights into the impact and scalability of these innovations, emphasizing their role in shaping a world-class education system. It concludes with recommendations for leveraging these innovations to enhance Qatar's education landscape, supporting the broader objectives of sustainable development and societal growth as envisioned in Qatar National Vision 2030.
ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING IN ECONOMICS: USING AI TECHNOLOGIES FOR DATA ANALYSIS. DEMAND FORECASTING, BUSINESS PROCESS OPTIMIZATION
Authors: Бокиева Регина Дилшодовна , Алферов Валерий Николаевич
Published: January 2025

В статье рассмотрено, что искусственный интеллект (AI) и машинное обучение (ML) радикально трансформировали бизнес, электронную коммерцию и веб-разработку, предоставляя предпринимателям новые инструменты для улучшения качества товаров и услуг, а также получения конкурентных преимуществ. Современные компании активно внедряют AI для анализа больших объемов данных, прогнозирования будущих событий и оптимизации бизнес-процессов. В работе определено, что одной из ключевых областей применения AI и МL является автоматизация рутинных задач, что позволяет сэкономить время и ресурсы, а также повысить эффективность работы. Кроме того, AI способен принимать решения на основе анализа данных и разрабатывать алгоритмы для оптимизации производственных процессов. В работе выделены определенные проблемы применения искусственного интеллекта и машинного обучения в бизнесе

The article says that artificial intelligence (AI) and machine learning (ML) have radically transformed business, e-commerce and web development, providing entrepreneurs with new tools to improve the quality of goods and services, as well as gain competitive advantages. Modern companies are actively implementing AI to analyze large amounts of data, predict future events and optimize business processes. The author believes that one of the key areas of application is automation of routine tasks, which saves time and resources, as well as increases work efficiency. Currently, AI is able to make decisions based on data analysis and develop algorithms to optimize production processes. At the same time, the article highlights certain problems of using AI and machine learning in business
16 СКЕЛЕТОВ - ПРЕДЕЛ БИОЛОГИЧЕСКОЙ ЖИЗНИ ЧЕЛОВЕКА НА ЗЕМЛЕ
Authors: Богданов Николай Иванович , Хецуриани Елгуджа Демуромич , Богданов Эдуард Николаевич , Хецуриани Тимур Елгуджиевич
Published: January 2025

Предложены медицинские и социальные мероприятия для увеличения долгожителей в России. Представлена графическая закономерность эволюции и инволюции скелета человека по определению возраста и предела биологической жизни человека на Земле
Educação em Direitos Humanos e a moralidade pós-convencional
Authors: Galvanese Ricardo Costa
Published: January 2025

Quais são as estruturas racionais necessárias à compreensão dos princípios que organizam o discurso dos Direitos Humanos e que conseguem sustentar a construção lógico-moral dos procedimentos de Educação em Direitos Humanos? Para responder a este problema, o presente artigo toma como objeto o desenvolvimento dos padrões de racionalidade moral numa perspectiva kohlberguiana. Tendo em vista a lógica moral subjacente aos Direitos Humanos, emprega como metodologia a pesquisa bibliográfico-documental baseada em técnicas de revisão narrativa de literatura e objetiva demonstrar a necessidade de fundamentação da Educação em Direitos Humanos em padrões pós-convencionais de cognição moral. Após uma breve descrição do cenário de ataques promovidos pelo bolsonarismo contra os Direitos Humanos e contra o Estado Democrático de Direito, são caracterizadas, em linhas gerais, as teorias de Piaget e Kohlberg sobre o desenvolvimento da racionalidade moral e após explorar alguns limites e possibilidades da pesquisa kohlberguiana, conclui que esta proporciona à Educação em Direitos Humanos uma fundamentação indispensável, pois revela que o discurso sobre os Direitos Humanos só é adequadamente decodificado e, portanto, compreensível, na medida em que esteja ancorado numa racionalidade moral pós-convencional.
Escritas de um tempo que atravessa
Authors: Da Silva Figueira Sandro Tiago , Gomes Martins Pinto Elisângela , Flávia Gomes Moura Flávia
Published: January 2025

Com o objetivo de problematizar os atravessamentos na temporalidade (Delory-Momberger, 2012) da constituição de pedagogos que se entrelaçam no interior da profissão enquanto itinerância de anúncios autorais (Freire, 1999), desenhamos o presente texto conjugando palavras que carregam o tempo docente no movimento de vida-formação e que nos convidam a pousar e reconhecer, de modo atento, os itinerários vividos na multiplicidade existencial com os encontros forjados na ambiência escolar, nos percursos e trajetos que ressoam no dia a dia da profissão. Para este intento, demarcamos o trilhar metodológico na pesquisa-formação (Josso, 2004) em diálogo com a perspectiva (auto)biográfica em educação (Passeggi e Souza, 2017) por meio das narrativas de formação. Organizamos as análises das narrativas no processo de tematização (Fontoura, 2011) no sentido de conjugar identidade docente e subjetividade para produzir levantes diante do contexto de esvaziamento da docência em sua inteireza. Concluímos que a temporalidade de vida-formação docente evoca a gestação de sentidos quando o percurso pedagógico é problematizado na direção de (cria)ação e autoria de conhecimentos e saberes cotidianos. Um saber prenhe de sentidos ambientado com a escola e na afirmação sócio-histórica da profissão, numa relação de viver e narrar para enredar e construir um tempo de aprender singular e coletivo justo socialmente.
Peluang Industri Pertanian Komoditas Kopi (Coffe) Di Kecamatan Seponti Kabupaten Kayong Utara Desa Sungai Sepeti
Authors: Martanto Martanto , Nur Aisyah Devi , Indriawan Rois
Published: January 2025

Industri kopi di Indonesia memiliki peran strategis dalam perekonomian nasional, berkontribusi sebagai sumber pendapatan bagi jutaan petani. Produksi mencapai 794,8 ribu ton pada tahun 2022. Indonesia termasuk salah satu negara penghasil kopi terbesar di dunia. Penelitian ini mengkaji peluang industri pertanian komoditas kopi di Kecamatan Seponti, Kabupaten Kayong Utara, yang memiliki potensi besar berkat kondisi agriklimat yang mendukung dan varietas kopi unggul. Permintaan global yang terus meningkat, didorong oleh pertumbuhan kelas menengah di negara berkembang, menciptakan peluang pasar yang luas. Namun, tantangan seperti peningkatan pendapatan petani, kualitas produksi, dan masalah lingkungan perlu diatasi. Penelitian ini bertujuan untuk mengeksplorasi strategi pengembangan industri kopi yang berkelanjutan, serta memberikan rekomendasi untuk meningkatkan kesejahteraan petani dan pertumbuhan ekonomi lokal. Hasil analisis peluang industri pertanian kopi di Desa Sungai Sepeti, ditemukan bahwa daerah ini memiliki potensi besar untuk mengembangkan industri kopi berkat kondisi agriklimat yang mendukung, seperti tanah subur dan curah hujan yang memadai sedangkan tren produksi kopi yang berubah sepanjang waktu di Desa Sungai Sepeti, pada penelitian menunjukkan bahwa meskipun ada peningkatan permintaan, industri kopi masih menghadapi tantangan dalam hal peningkatan kualitas produksi dan manajemen sumber daya.
Pendidikan Karakter Gotong Royong melalui Implementasi Kurikulum Merdeka pada Mata Pelajaran Pendidikan Agama Islam dan Budi Pekerti di SDN 15 Ampang Gadang
Authors: Arismanto Arismanto , Rahman Yulia
Published: January 2025

This research was motivated by several problems, namely, the implementation of the Pancasila student profile which was not optimal, especially regarding mutual cooperation. There are still students who have difficulty carrying out learning using collaborative methods at SDN 15 Ampang Gadang. The spirit of cooperation is fading among students at SDN 15 Ampang Gadang. Therefore, this research aims to determine Mutual Cooperation Character Education through the Implementation of the Independent Curriculum in Islamic Religious Education and Character Education Subjects at SDN 15 Ampang Gadang. The method in this research uses descriptive qualitative, namely, to reveal facts, circumstances, phenomena and circumstances that occur while the research is running. The informants in this research were Islamic Religious Education and Character Teachers. Meanwhile, the location of this research was carried out at SDN 15 Ampang Gadang and the data collection techniques used in this research were observation, interviews and documentation. The results of the research obtained regarding Mutual Cooperation Character Education through the Implementation of the Independent Curriculum in Islamic Religious Education Subjects are that Islamic Religious Education teachers appreciate and strongly support Mutual Cooperation Character Education. This form of appreciation was realized by creating a congregational noon prayer program in turns. The implementation of Mutual Cooperation Character Education is carried out at the planning, implementation and evaluation stages. Moral knowing from the planning, implementation and evaluation stages is quite good, because it is in accordance with theory. While the moral feeling is less formed, the moral action is more visible, because there is already a practice of mutual cooperation in implementation. The supporting factors are adequate facilities and infrastructure. The inhibiting factor is the lack of students' understanding of what must be done, in other words the lack of awareness of students to work together.
Studi Nuzulul Qur’an dalam Kajian Al-Qur’an Surat Al-Baqarah Ayat 185
Authors: Anshory Muhammad Isa , Aziz Nur , Al Faizi Ahmad Akbar , Dewi Rachma Rusdiana
Published: January 2025

This research aims to analyze the concept of Nuzulul Qur'an in the context of Al-Baqarah verse 185, which concerns the obligation to fast in the month of Ramadan. Nuzulul Qur'an refers to the gradual decline of Allah's revelations to the Prophet Muhammad SAW over 23 years. Surah Al-Baqarah verse 185 explains the rules for implementing fasting during the month of Ramadan, as well as the wisdom behind this obligation. This research uses a historical interpretation approach (tafsir asbabun nuzul) to explore the background to the revelation of this verse and its relevance in the social and religious context of that time. Apart from that, this research also examines the application of this verse in the lives of Muslims from a theological and practical perspective. The research results show that this verse was revealed as a response to the situation of the people of Mecca who at that time needed practical guidance regarding fasting. This research also highlights the deep meaning behind fasting as a means of spiritual formation, building self-discipline, and increasing social awareness. Thus, it is hoped that this research can provide a more comprehensive understanding of the importance of the values ​​contained in this verse and their relevance in the lives of Muslims today.
The Study on the Functional State of the Vestibular Analyzer among Students and Some Methods for its Improvement
Authors: Kirakosyan Mery , Manukyan Tatevik
Published: January 2025

Key words: equilibrium, vestibular disfunction, static stability, motor coordination statokinetic tests, statocoordinator tests

The vestibular analyzer is essential for the physical, intellectual, speech, and emotional development of children. However, the functional state of the vestibular apparatus among adolescents and its potential disorders remain insufficiently studied. Given the importance of this issue, we assessed the vestibular analyzer's functional state among 9th-grade pupils from N.1 and N.23 Basic Schools of Vanadzor, as well as the influence of a special set of exercises on the indices of stability of the functional state of the vestibular analyzer. As a result of the study, through statocoordinator and statokinetic tests, pupils with vestibular disorders were identified.
After implementing a special set of exercises with an experimental group, the results of the “Romberg pose” test with open eyes indicated an increase in the average index of static stability by 10.98 %, while the test with closed eyes showed an increase of 9.95 % in static stability. This targeted exercise set, aimed at enhancing the vestibular analyzer to maintain a stable upright posture, yielded positive outcomes.
Based on these findings, we recommend evaluating pupils’ vestibular analyzer functionality to identify those with vestibular disfunction. The paper emphasizes the proper distribution of physical activity during physical education classes, and we further recommend incorporating specialized exercises to improve the vestibular analyzer's functional state.
Fear of Missing Out of Stock Investment among Millennial and Zillennial Investors
Authors: Ridzky Mochammad , Arsyianti Laily Dwi
Published: January 2025

This study attempts to analyze the characteristics, the fear of missing out (FoMO) tendency, and the factors influence investment intention and investment decision of the Ajaib Sekuritas application users. Design/methodology/approach. This research utilizes primary data from 180 respondents which are analyzed using Structural Equation Modeling- Partial Least Square Analysis (SEM-PLS) based on the UTAUT2 model. The findings of this research show that the variables of social influence, satisfaction, and price value have a positive and significant impact on investment intentions. Furthermore, the fear of missing out and investment intentions are positively and significantly affecting the investment decision. The term FoMO has been widely known as behavioral finance component as the common term used. However, none study specifically elaborate this issue. Thus, this study presumably among the first that raise particularly on FoMO as part of empirical study.
Perananan Pelaksanaan Administrasi Kurikulum Pendidikan
Authors: Khairan Sari  , Elsa Dwi Putri  , Atika Ainur Rahman  , Yessi Rifmasari
Published: January 2025

This study aims to study the concept of curriculum administration process. Curriculum is a set of plans and regulations regarding the content and learning materials and methods used as guidelines in the implementation of the teaching and learning process. The curriculum administration process consists of planning, implementation, monitoring and evaluation. The curriculum is a planning document that contains the objectives to be achieved, the content of the material and learning experiences that students must do, strategies and methods that can be developed, evaluations designed to collect information about the achievement of objectives, and the implementation of documents designed in real form. Thus, the curriculum plays an important role in the success of student education. One aspect that can increase the success of the curriculum is the administration of the implementation of the curriculum at the relevant educational institution, in other words, the implementation of the curriculum is institutional in nature. This study focuses on the literature study method by collecting literature (related materials) sourced from books, journals, and other sources related to the science of Administration. The term curriculum administration emphasizes efforts to direct the curriculum so that the curriculum can be implemented appropriately in various educational activities
Agama Sebagai Institusi Sosial (Tinjauan Literatur Sosiologi Agama)
Authors: Sahdin Hasibuan  , Muhammad Fikih Alpiansyah  , Dermawan Jihad  , Fahrul Rozi  , Ahmad Ammar
Published: January 2025

This study aims to explore the role of religion as a social institution in the context of the study of religious sociology literature. The research methodology applied in this study is qualitative, with an approach based on literature review. The findings of the study indicate that religion functions as a social phenomenon that is inseparable from people's lives, regardless of any level of culture. Religion will continue to maintain its existence in society, because of its fundamental function. Religion can be considered a social institution, considering its existence in society, where religion is an entity that is recognized, understood, obeyed, and respected by the community. The conflicts or tensions that arise due to religion are not caused by religion itself, but by the excessive fanaticism of its adherents or by the extreme changes that occur in their communities.
Relato de caso de endocardite por Priestia megaterium
Authors: Bidinotto Lucas , Da Silva Marcia Guimarães , Pierre Maria Eduarda , Gomes Camila Moreira , Jorge Luciana Souza
Published: January 2025

Endocardite é uma infecção grave associada a morbimortalidade importante e pode ser causada por vários microrganismos, mais frequentemente por Enteroccus faecalis, Staphylococcus aureus e Streptococcus sp. O tratamento de pacientes com endocardite infecciosa grave é particularmente desafiador em hospitais não terciários. Um homem imunocompetente de 26 anos foi internado no hospital com início súbito de náusea, seguido por um episódio de síncope de 10 segundos com falta de resposta e perda de memória. Ele foi submetido a uma ressonância magnética do crânio, revelando múltiplas lesões nodulares intraparenquimatosas com um processo inflamatório/infeccioso. O ecocardiograma transesofágico mostrou prolapso de valva mitral com insuficiência moderada/severa. Jato excêntrico, intenso e triangular, com direção à região posterior do átrio esquerdo, com fluxo sistólico reverso em veias pulmonares. Foi observada também imagem ecoanômala, com ampla mobilidade, medindo 2,6cm x 0,6cm, aderida à face atrial do folheto posterior da valva mitral. Notou-se por fim deslizamento do folheto posterior sobre o folheto anterior, compatível com ruptura parcial da cordoalha mitral do folheto posterior. Foi realizada terapia antimicrobiana empírica com ampicilina, oxacilina e gentamicina. O paciente foi submetido à substituição da valva mitral por uma prótese biológica. Os resultados da cultura do tecido valvar identificaram Priestia megaterium e o tratamento antimcrobiano foi substituído por vancomicina e gentamicina foi mantido. Após 14 dias, todos os sintomas foram resolvidos e o paciente recebeu alta do hospital. Até o momento, este é o primeiro relato de endocardite por P. megaterium e o potencial patogênico de P. megaterium justifica uma investigação mais aprofundada.
Toxina botulínica no tratamento da depressão: uma revisão atualizada das evidências científicas
Authors: Prata Celina Antonio , Gomes Aparecido Viana , Prata Marina Antonio
Published: January 2025

A depressão é uma condição que atinge quase 300 milhões de pessoas no mundo todo, sendo considerada a principal causa de incapacidade. Há uma necessidade de novas abordagens para tratar a depressão, com efeitos colaterais mínimos, para melhora adesão ao tratamento e menores interações farmacológicas. Vários estudos mostraram que uma única injeção de toxina botulínica nos músculos da região glabelar pode um tratamento eficaz e bem tolerado para a depressão. O objetivo deste trabalho foi realizar uma revisão de literatura sobre o uso da toxinabotulínica nos tratamentos de depressão. Foi realizada uma pesquisa nas bases de dados PubMed, Web of Science, Scopus e Lilacs compreendendo principalmente o período dos últimos 20 anos, através das palavras-chaves: “botulinum toxin”, “depression”, “toxin botulinum and depression”. Foram selecionados 16 trabalhos clínicos mais relevantes e, a partir destes, outras referências foram localizadas. Concluímos que uma série de trabalhos clínicos randomizados e meta-análises mostraram que injeções de toxina botulínica na glabela e em outros locais do corpo, podem reduzir os sintomas de depressão leve a moderada. Com base em sua indicação estética, a toxina botulínica pode ser usada no manejo clínico da depressão, tendo se mostrado uma opção útil para pacientes que não conseguem melhora ou que apresentaram efeitos colaterais com tratamentos antidepressivos mais utilizados. A explicação mais aceita é que tratamento com toxina botulínica tem o feedback proprioceptivo da face como um efeito positivo no humor depressivo. No entanto, os mecanismos reais de ação ainda são desconhecidos e são objeto de pesquisas em andamento.