bluuebunny/crossref_metadata_2025 huggingface dataset:
Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia
Authors: Blette Bryan S. , Granholm Anders , Li Fan , Shankar-Hari Manu , Lange Theis , Munch Marie Warrer , Møller Morten Hylander , Perner Anders , Harhay Michael O.
Published: April 2023

The currently recommended dose of dexamethasone for patients with severe or critical COVID-19 is 6 mg per day (mg/d) regardless of patient features and variation. However, patients with severe or critical COVID-19 are heterogenous in many ways (e.g., age, weight, comorbidities, disease severity, and immune features). Thus, it is conceivable that a standardized dosing protocol may not be optimal. We assessed treatment effect heterogeneity in the COVID STEROID 2 trial, which compared 6 mg/d to 12 mg/d, using a causal inference framework with Bayesian Additive Regression Trees, a flexible modeling method that detects interactive effects and nonlinear relationships among multiple patient characteristics simultaneously. We found that 12 mg/d of dexamethasone, relative to 6 mg/d, was probably associated with better long-term outcomes (days alive without life support and mortality after 90 days) among the entire trial population (i.e., no signals of harm), and probably more beneficial among those without diabetes mellitus, that were older, were not using IL-6 inhibitors at baseline, weighed less, or had higher level respiratory support at baseline. This adds more evidence supporting the use of 12 mg/d in practice for most patients not receiving other immunosuppressants and that additional study of dosing could potentially optimize clinical outcomes.
The sex impact on the technological and chemical characteristics of meat derived from the Polish native chicken breed
Authors: Kasperek Kornel , Drabik Kamil , Sofińska-Chmiel Weronika , Karwowska Małgorzata , Zięba Grzegorz , Batkowska Justyna
Published: April 2023

The aim of the study was to evaluate the birds’ sex as well as the caponisation influence on the technological traits of obtained meat, fatty acids profile as well as main chemical compounds distribution. In this study, 40 hens, roosters and green-legged partridge capons each were used (4 replications each). At 24 weeks of age, 2 birds from each replication subgroup were selected and slaughtered. During dissection analysis, pectoral and femoral muscles were sampled. Acidity, colour, tenderness, water holding capacity, drip and cooking loss were determined in the obtained material. The fatty acid profile of the meat was also determined, as well as the distribution of components in the pressed meat samples using FTIR spectroscopy. Statistically significant differences in the colour lightness index (L*) of the breast muscles were recorded, with cockerel meat being the darkest and capon meat the lightest. The greatest natural water loss was recorded in the hens' pectoral muscle; cooking loss was also the greatest in these samples. Roosters showed significantly the lowest content of monounsaturated fatty acids, at the same time the highest proportion of the n3 fatty acids group was found in capons. Irrespective of muscle, meat from roosters showed the highest susceptibility to oxidation (PI index). The variation in the chemical composition of the meat was confirmed by FTIR mapping.
The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients
Authors: Koivula Tiia , Lempiäinen Salla , Rinne Petteri , Rannikko Jenna H. , Hollmén Maija , Sundberg Carl Johan , Rundqvist Helene , Minn Heikki , Heinonen Ilkka
Published: April 2023

The role of exercise in cancer prevention and control is increasingly recognized, and based on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important role in the anti-tumor effect. Thus, we examined how 10-min acute exercise modulates immune cells in newly diagnosed breast cancer patients. Blood samples were taken at rest, immediately after exercise and 30 min after exercise and phenotypic characterization of major leukocyte subsets was done using 9-color flow cytometry. Total leukocyte count increased by 29%, CD8+ T cell count by 34%, CD19+ B cell count by 18%, CD56+CD16+ NK cell count by 130%, and CD14+CD16+ monocyte count by 51% immediately after acute exercise. Mobilization of CD45+, CD8+, CD19+, and CD56+CD16+ cells correlated positively with exercising systolic blood pressure, heart rate percentage of age predicted maximal heart rate, rate pressure product, and mean arterial pressure. Our findings indicate that a single bout of acute exercise of only 10 min can cause leukocytosis in breast cancer patients. Mobilization of leukocytes appear to be directly related to the intensity of exercise. It is possible that the positive effect of exercise on oncologic outcome might be partly due to immune cell mobilization as documented in the present study.
CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice
Authors: Kim Boe-Hyun , Hadas Eran , Kelschenbach Jennifer , Chao Wei , Gu Chao-Jiang , Potash Mary Jane , Volsky David J.
Published: April 2023

HIV enters the brain within days of infection causing neurocognitive impairment (NCI) in up to half of infected people despite suppressive antiretroviral therapy. The virus is believed to enter the brain in infected monocytes through chemotaxis to the major monocyte chemokine, CCL2, but the roles of CCL2 in established NCI are not fully defined. We addressed this question during infection of conventional and CCL2 knockout mice with EcoHIV in which NCI can be verified in behavioral tests. EcoHIV enters mouse brain within 5 days of infection, but NCI develops gradually with established cognitive disease starting 25 days after infection. CCL2 knockout mice infected by intraperitoneal injection of virus failed to develop brain infection and NCI. However, when EcoHIV was directly injected into the brain, CCL2 knockout mice developed NCI. Knockout of CCL2 or its principal receptor, CCR2, slightly reduced macrophage infection in culture. Treatment of mice prior to and during EcoHIV infection with the CCL2 transcriptional inhibitor, bindarit, prevented brain infection and NCI and reduced macrophage infection. In contrast, bindarit treatment of mice 4 weeks after infection affected neither brain virus burden nor NCI. Based on these findings we propose that HIV enters the brain mainly through infected monocytes but that resident brain cells are sufficient to maintain NCI. These findings suggest that NCI therapy must act within the brain.
The association between acetylsalicylic acid and subarachnoid haemorrhage: the Framingham Heart Study
Authors: Ewbank Frederick , Birks Jacqueline , Bulters Diederik
Published: April 2023

Studies investigating the association between acetylsalicylic acid (ASA) use and spontaneous subarachnoid haemorrhage (SAH) in the general population have produced conflicting results. The aim of this study is to clarify the relationship between SAH and ASA. We included all participants who reported on ASA use during interim examinations of the Framingham Heart Study Cohorts. Using Cox proportional-hazards regression modelling, we estimated the hazard ratio (HR) associated with ASA use. 7692 participants were included in this study. There were 30 cases of SAH during follow up, with an estimated incidence of 10.0 per 100,000 person- years (CI 6.90–14.15). Univariate analysis showed no association between regular ASA use and SAH (HR, 0.33 [0.08–1.41]; p = 0.14). This was similar when accounting for smoking (HR, 0.35 [0.08–1.51]; p = 0.16). Using a large longitudinal dataset from the Framingham Heart Study, we observed some evidence suggesting fewer SAH in those participants taking regular ASA. However, multivariate statistical analysis showed no significant association between ASA use and SAH. Due to the low incidence of SAH in the general population, the absolute number of SAH events was low and it remains uncertain if a significant effect would become apparent with more follow up.
Influenza season influence on outcome of new nodules in the NELSON study
Authors: Lancaster H. L. , Heuvelmans M. A. , de Bock G. H. , Du Y. , Mohamed Hoesein F. A. A. , Nackaerts K. , Walter J. E. , Vliegenthart R. , Oudkerk M.
Published: April 2023

We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.
Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis
Authors: Urbaniak Anna , Jablonska Karolina , Suchanski Jaroslaw , Partynska Aleksandra , Szymczak-Kulus Katarzyna , Matkowski Rafal , Maciejczyk Adam , Ugorski Maciej , Dziegiel Piotr
Published: April 2023

We have previously shown that high expression of prolactin-induced protein (PIP) correlates with the response of breast cancer (BC) patients to standard adjuvant chemotherapy (doxorubicin and cyclophosphamide), which suggests that the absence of this glycoprotein is associated with resistance of tumor cells to chemotherapy. Therefore, in the present study, we analyzed the impact of PIP expression on resistance of BC cells to anti-cancer drugs and its biological role in BC progression. Expression of PIP and apoptotic genes in BC cell lines was analyzed using real-time PCR and Western blotting. PIP was detected in BC tissue specimens using immunohistochemistry. The tumorigenicity of cancer cells was analyzed by the in vivo tumor growth assay. Apoptotic cells were detected based on caspase-3 activation, Annexin V binding and TUNEL assay. The interaction of PIP with BC cells was analyzed using flow cytometry. Using two cellular models of BC (i.e. T47D cells with the knockdown of the PIP gene and MDA-MB-231 cells overexpressing PIP), we found that high expression of PIP resulted in (1) increased sensitivity of BC cells to apoptosis induced by doxorubicin (DOX), 4-hydroperoxycyclophosphamide (4-HC), and paclitaxel (PAX), and (2) improved efficacy of anti-cancer therapy with DOX in the xenograft mice model. Accordingly, a clinical study revealed that BC patients with higher PIP expression were characterized by longer 5-year overall survival and disease-free survival. Subsequent studies showed that PIP up-regulated the expression of the following pro-apoptotic genes: CRADD, DAPK1, FASLG, CD40 and BNIP2. This pro-apoptotic activity is mediated by secreted PIP and most probably involves the specific surface receptor. This study demonstrates that a high expression level of PIP sensitizes BC cells to anti-cancer drugs. Increased sensitivity to chemotherapy is the result of pro-apoptotic activity of PIP, which is evidenced by up-regulation of specific pro-apoptotic genes. As high expression of PIP significantly correlated with a better response of patients to anti-cancer drugs, this glycoprotein can be a marker for the prognostic evaluation of adjuvant chemotherapy.
Modeling of the movement of rich gas in a porous medium in immiscible, near miscible and miscible conditions
Authors: Mehrjoo Hossein , Safaei Ali , Kazemzadeh Yousef , Riazi Masoud , Cortés Farid B.
Published: April 2023

Gas injection is one of the most common enhanced oil recovery techniques in oil reservoirs. In this regard, pure gas, such as carbon dioxide (CO2), nitrogen (N2), and methane (CH4) was employed in EOR process. The performance of pure gases in EOR have been investigated numerically, but till now, numerical simulation of injection of rich gases has been scared. As rich gases are more economical and can result in acceptable oil recovery, numerical study of the performance of rich gases in EOR can be an interesting subject. Accordingly, in the present work the performance of rich gases in the gas injection process was investigated. Methane has been riched in liquefied petroleum gas (LPG), natural gas liquid (NGL), and Naphtha. Afterwards, the process of gas injection was simulated and the effect of injection fluids on the relative permeability, saturation profile of gas, and fractional flow of gas was studied. Our results showed that as naphtha is a heavier gas than the two other ones, IFT of oil-rich gas with naphtha is lower than other two systems. Based our results, gas oil ratio (GOR) and injection pressure did not affect the final performance of injection gas that has been riched in NGL and LPG. However, when GOR was 1.25 MSCF/STB, rich gas with naphtha moved with a higher speed in the domain and the relative permeability of each fluid and fractional flow of gas were affected. The same result was achieved at higher injection pressure. When injection pressure was 2000 psi, movement of gas with higher speed in the domain, alteration of relative permeability and changes in the fractional flow of gas were obvious. Therefore, based on our result, injection of naphtha with low pressure and high GOR was suggested for considered oil.
First evidence of industrial fly-ash in an Antarctic ice core
Authors: Thomas E. R. , Tetzner D. R. , Roberts S. L. , Turner S. D. , Rose N. L.
Published: April 2023

Spheroidal carbonaceous particles (SCPs) are a component of fly-ash, the particulate by-product of industrial high temperature combustion of fuel-oil and coal-series fuels. We provide the first evidence that these indelible markers of industrialisation have been deposited in Antarctic ice, thousands of kilometres from any potential source. The earliest observed particle was deposited in an ice layer from 1936 CE. While depositional fluxes are low, chemical analysis of individual SCPs indicates a coal combustion origin.
Chemistry of two-dimensional pnictogens: emerging post-graphene materials for advanced applications
Authors: Lucherelli Matteo Andrea , Oestreicher Víctor , Alcaraz Marta , Abellán Gonzalo
Published: April 2023

The scheme shows the most common two-dimensional pnictogen structures and their corresponding alchemical symbols. In this Feature Article some of the most recent developments in chemistry of these ancient elements will be reviewed.
Patterns in undergraduate students’ and educators’ sense of the ontology of the atom and implications for addressing learning impediments
Authors: Lemma Abayneh , Belachew Woldie
Published: April 2023

In this study, we explored undergraduate chemistry education at Kotebe University of Education (KUE) in terms of the ontological orientations, patterns and source domains of educators’ and undergraduate students’ sense of the atom. Due to the ambiguity and controversy regarding atomic ontology as a case of interest and the requirement for a thorough analysis, an interpretative case study design was employed. It mainly involved a semi-structured interview of 10 educators and 14 undergraduate students. The analysis involved Charmaz's approach for coding. Four core patterns were found to constitute the overall narrative of educators and undergraduate students, from which the interpretative, mechanical, and hypothetical orientations were implied. The ways of thinking in the three patterns were traced back to the underemphasis and distorted portrayal of the History and Philosophy of Science (HPS) in the curriculum and classroom discourse. The usage of some words and expressions with mechanical connotations was also discovered to be the fourth theme of patterns to which the mechanical orientations are attributed. Views of controversial ontologies are held by the participants of this single system. There is also an emerging inclination among undergraduate students toward reductionism, which is not expected from a chemistry student. Therefore, this study implies that the historical and philosophical aspects need to be critically examined in classroom instruction, curriculum development, professional development of educators, and research on chemistry education to avoid ontological complications and address learning impediments. The instructional approaches, materials, and classroom discourse also need to be examined carefully from an ontological point of view to avoid unnecessary complications and obstacles.
Designing protein nano-construct in ionic liquid: a boost in efficacy of cytochrome C under stresses
Authors: Thayallath Sarath Kumar , Shet Sachin M. , Bisht Meena , Bharadwaj Pranav , Pereira Matheus M. , Franklin Gregory , Nataraj S. K. , Mondal Dibyendu
Published: April 2023

Herein, we report a facile approach to develop protein nanoconstructs of cytochrome C with silk nanofibrils in the presence of ionic liquid with improved stability and activity against various harsh conditions.
The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes
Authors: Campanile Marco , Oliva Rosario , Del Vecchio Pompea , Winter Roland , Petraccone Luigi
Published: April 2023

LL-III preferentially binds G-quadruplexes involved in carcinogenesis and represents a lead peptide for the development of new peptide-based anticancer drugs.
Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers
Authors: Zhao Yibo , Chen Longming , Chen Junyi , Li Jian , Meng Qingbin , Sue Andrew C.-H. , Li Chunju
Published: April 2023

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups.
Lattice thermal conductivity and Young's modulus of XN4 (X = Be, Mg and Pt) 2D materials using machine learning interatomic potentials
Authors: Ghorbani Khashayar , Mirchi Pedram , Arabha Saeed , Rajabpour Ali , Volz Sebastian
Published: April 2023

DFT and Machine-learning interatomic potential combination for thermal and mechanical properties prediction of nitrogen-rich 2D materials.
Facile one-step synthesis of a niobium iron oxide based electrochemical transistor for rapid, label-free detection of folic acid in human blood serum samples
Authors: Sreekumar Anjali , Durai Lignesh , Badhulika Sushmee
Published: April 2023

An inorganic electrochemical transistor to detect folic acid in human blood serum.
A fluoro-alkene mimic of Gly-trans-Pro produces a stable collagen triple helix
Authors: Arcoria Paul J. , Etzkorn Felicia A.
Published: April 2023

We report the first experimental evidence for a fluoro-alkene amide isostere participating in n→π* donation, which stabilizes the collagen triple helix.
Microwave-promoted radical addition/cyclization of biaryl vinyl ketones with diacyl peroxides in water under metal-free conditions
Authors: Yang Xingyu , Zhang Gan , Zhou Jingwen , Zhou Chao , Wang Lei , Li Pinhua
Published: April 2023

An efficient microwave-promoted radical addition/cyclization reaction of biaryl vinyl ketones with diacyl peroxides in water under metal-free conditions was developed.
Correction: Concise synthesis of 2,3-disubstituted quinoline derivatives via ruthenium-catalyzed three-component deaminative coupling reaction of anilines, aldehydes and amines
Authors: Shakenov Aldiyar , Gnyawali Krishna Prasad , Yi Chae S.
Published: April 2023

Correction for ‘Concise synthesis of 2,3-disubstituted quinoline derivatives via ruthenium-catalyzed three-component deaminative coupling reaction of anilines, aldehydes and amines’ by Aldiyar Shakenov et al., Org. Biomol. Chem., 2023, https://doi.org/10.1039/d3ob00348e.
Halogen-induced planar defects in Cu catalysts for ammonia electrosynthesis at an ampere-level current density
Authors: Wang Yan , Xia Shuai , Zhang Jianfang , Ummireddi Ashok Kumar , Li Zhengyuan , Yuan Xu , Yu Cuiping , Zhang Yong , Wu Jingjie , Wu Yucheng
Published: April 2023

The electrocatalytic nitrate reduction reaction (NO3−RR) provides an effective route for removing NO3−from wastewater and converting it to valuable ammonia (NH3).
Electron-transfer enhancement of urchin-like CoP–Ce2(CO3)2O/NF as an ultra-stable bifunctional catalyst for efficient overall water splitting
Authors: Wang Lixia , Huang Meilin , Gao Mingcheng , Isimjan Tayirjan Taylor , Yang Xiulin
Published: April 2023

An urchin-like CoP–Ce2(CO3)2O/NF bifunctional catalyst was successfully constructed by a facile hydrothermal and gas-phase phosphating process, which exhibits extraordinary HER and OER performance (η10= 85.2 and 205.5 mV) in alkaline solution.
Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models
Authors: Shah Nisar Zamin , Avula Satya Kumar , Karim Nasiara , Islam Nazar Ul , El-Saber Batiha Gaber , Muhsinah Abdullatif Bin , Khan Ajmal , Al-Harrasi Ahmed
Published: April 2023

Post-operative and chronic inflammatory activity of ibuprofen derivatives in painin vivomodels.
Dihydrophenazine-derived oligomers from industrial waste as sustainable superior cathode materials for rechargeable lithium-ion batteries
Authors: He Qimin , Lv Shaoyu , Huang Yuanzhu , Guo Jingying , Peng Xiangling , Du Ya , Yang Haishen
Published: April 2023

From an industrial waste phenazine, a series of novel redox-active materials were effectively achieved and exploited as sustainable superior organic cathode materials of lithium-ion batteries.
Correction: Tunable optical properties of transition metal dichalcogenide nanoparticles synthesized by femtosecond laser ablation and fragmentation
Authors: Chernikov Anton S. , Tselikov Gleb I. , Gubin Mikhail Yu. , Shesterikov Alexander V. , Khorkov Kirill S. , Syuy Alexander V. , Ermolaev Georgy A. , Kazantsev Ivan S. , Romanov Roman I. , Markeev Andrey M. , Popov Anton A. , Tikhonowski Gleb V. , Kapitanova Olesya O. , Kochuev Dmitry A. , Leksin Andrey Yu. , Tselikov Daniil I. , Arsenin Aleksey V. , Kabashin Andrei V. , Volkov Valentyn S. , Prokhorov Alexei V.
Published: April 2023

Correction for ‘Tunable optical properties of transition metal dichalcogenide nanoparticles synthesized by femtosecond laser ablation and fragmentation’ by Anton S. Chernikov et al., J. Mater. Chem. C, 2023, 11, 3493–3503, https://doi.org/10.1039/D2TC05235K.
Antiviral activities of hemp cannabinoids
Authors: van Breemen Richard B. , Simchuk Daniel
Published: April 2023

Hemp is an understudied source of pharmacologically active compounds and many unique plant secondary metabolites including more than 100 cannabinoids. After years of legal restriction, research on hemp has recently demonstrated antiviral activities in silico, in vitro, and in vivo for cannabidiol (CBD), Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and several other cannabinoids against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus (HIV), and γ-herpes viruses. Mechanisms of action include inhibition of viral cell entry, inhibition of viral proteases, and stimulation of cellular innate immune responses. The anti-inflammatory properties of cannabinoids are also under investigation for mitigating the cytokine storm of COVID-19 and controlling chronic inflammation in people living with HIV. Retrospective clinical studies support antiviral activities of CBD, Δ9-THC, and cannabinoid mixtures as do some prospective clinical trials, but appropriately designed clinical trials of safety and efficacy of antiviral cannabinoids are urgently needed.
Time‐harmonic field‐circuit model for brushless doubly fed induction machine
Authors: Jagiela Mariusz , Wang Xiaoyan , McMahon Richard A. , Garbiec Tomasz
Published: April 2023

A computationally efficient time‐harmonic finite element model for the steady‐state analysis of a brushless doubly fed induction machine (BDFIM) is proposed. In the model, the electromagnetic couplings of the BDFIM are described by means of the sum of two complex magnetic vector potentials that represent the two fundamental harmonic time components of the magnetic flux density distribution in the rotor frame of reference. As in an ordinary induction motor, the non‐linearity of the magnetisation characteristic is accounted for using an effective magnetic permeability. For the BDFIM, this is derived by considering the features of modulated magnetic flux density waveform. The accuracy of the approach has been validated by comparing the characteristics of a D270 machine operating in the double‐feed mode with ones obtained from the experimentally verified time‐stepping model at various operating conditions. High accuracy of the results coming from the proposed model is demonstrated even under deep saturation conditions within the magnetic circuit.
Taxonomy of outlier detection methods for power system measurements
Authors: Patel Viresh , Kapoor Aastha , Sharma Ankush , Chakrabarti Saikat
Published: April 2023

The new emerging technologies utilize various sensors, deployed in an as hoc manner to reduce energy consumption in data communication. The data collected from these sensors is huge and have a high possibility of being polluted by outliers. Therefore, researchers are trying to develop better and faster outlier detection techniques that can handle large amount of data. Here, the research works from the year 2000 to 2022 have been reviewed. Several fundamental and latest outlier detection methods are discussed and categorized on the basis of statistical properties, density, distance, and clustering. The other methods discussed here are ensemble methods and learning‐based methods. The definitions, causes of outliers, and different methods of outlier detection are discussed. Further, one of the efficient methods from each category of the method is implemented on synthetic data of the IEEE 13‐bus distribution system. The IEEE 13‐bus system is assumed to have a Multi‐Function Meter at each line in the system. The data captured is injected with a fixed number of outliers at a given instant. Thereafter, the performance of all the methods is tested based on the number of outliers being detected.
DIPNet: Driver intention prediction for a safe takeover transition in autonomous vehicles
Authors: Bonyani Mahdi , Rahmanian Mina , Jahangard Simindokht , Rezaei Mahdi
Published: April 2023

Following the successful development of advanced driver assistance systems (ADAS), the current research directions focus on highely automated vehicles aiming at reducing human driving tasks, and extending the operational design domain, while maintaining a higher level of safety. Currently, there are high research demands in academia and industry to predict driver intention and understating driver readiness, e.g. in response to a “take‐over request” when a transition from automated driving mode to human mode is needed. A driver intention prediction system can assess the driver's readiness for a safe takeover transition. In this study, a novel deep neural network framework is developed by adopting and adapting the DenseNet, long short‐term memory, attention, FlowNet2, and RAFT models to anticipate the diver maneuver intention. Using the public “Brain4Cars” dataset, the driver maneuver intention will be predicted up to 4 s in advance, before the commencement of the driver's action. The driver intention prediction is assessed based on 1) in‐cabin 2) out‐cabin (road) and 3) both in‐out cabin video data. Utilizing K‐fold cross‐validation, the performance of the model is evaluated using accuracy, precision, recall, and F1‐score metrics. The experiments show the proposed DIPNet model outperforms the state‐of‐the‐art in the majority of the driving scenarios.
Behaviour modelling of passive intermodulation in a complex non‐linear system
Authors: Luo Junyu , Gao Jinchun , Bi Lingyu , Wang Ziren , Xu Xiaolong , Zhou Yilin , Xie Gang
Published: April 2023

A novel method for modelling the passive intermodulation (PIM) in radio frequency (RF) devices, which works as a complex non‐linear system, was proposed. Both behaviour modelling and experimental validation were introduced to clarify the generation of PIM in a parallel and series non‐linear system. Taking the coaxial connector as an example, two types of N‐type connectors with 4 and 6 contact petals were selected and put into research. The measurements both agree well with the predicted results, validating the proposed model.
Optical magnetic field sensors based on nanodielectrics: From biomedicine to IoT‐based energy internet
Authors: Zhang Jia‐Wei , Meng Xuan , Han Tao , Wei Xiaofei , Wang Liang , Zhao Yu , Fu Geng , Tian Ning , Wang Qian , Qin Sichen , Liu Xiaoxu , Putson Chatchai
Published: April 2023

Smart sensors with excellent performance are accelerating the development of biomedicine and the Internet of Energy. Nanodielectrics exhibit unique electrical and mechanical properties. As the predominant materials in optical magnetic field sensor (MFS), they can not only exert the anti‐interference of optical sensing, but improve the measuring characteristics of optical sensors. For instance, the optical fibre quantum probe for the magnetic field can obtain a higher sensitivity of 0.57 nT/Hz1/2, while the measurement range of the sensor that uses Co‐doped ZnO nanorods as cladding is 17–180 mT. Here, these exciting recent achievements in the realm of optical sensing methods for magnetic field detection are reviewed, with a focus on nanodielectrics, which provide an emerging opportunity to achieve higher sensitivity and a wider measurement range of MFS.
GRBAlpha: The smallest astrophysical space observatory
Authors: Pál András , Ohno Masanori , Mészáros László , Werner Norbert , Řípa Jakub , Csák Balázs , Dafčíková Marianna , Frajt Marcel , Fukazawa Yasushi , Hanák Peter , Hudec Ján , Husáriková Nikola , Kapuš Jakub , Kasal Miroslav , Kolář Martin , Koleda Martin , Laszlo Robert , Lipovský Pavol , Mizuno Tsunefumi , Münz Filip , Nakazawa Kazuhiro , Rezenov Maksim , Šmelko Miroslav , Takahashi Hiromitsu , Topinka Martin , Urbanec Tomáš , Breuer Jean-Paul , Bozóki Tamás , Dálya Gergely , Enoto Teruaki , Frei Zsolt , Friss Gergely , Galgóczi Gábor , Hroch Filip , Ichinohe Yuto , Kapás Kornél , Kiss László L. , Matake Hiroto , Odaka Hirokazu , Poon Helen , Povalač Aleš , Takátsy János , Torigoe Kento , Uchida Nagomi , Uchida Yuusuke
Published: April 2023

Aims. Since it launched on 22 March 2021, the 1U-sized CubeSat GRBAlpha operates and collects scientific data on high-energy transients, making it the smallest astrophysical space observatory to date. GRBAlpha is an in-orbit demonstration of a gamma-ray burst (GRB) detector concept suitably small to fit into a standard 1U volume. As was demonstrated in a companion paper, GRBAlpha adds significant value to the scientific community with accurate characterization of bright GRBs, including the recent outstanding event of GRB 221009A.

Methods. The GRB detector is a 75 × 75 × 5 mm CsI(Tl) scintillator wrapped in a reflective foil (ESR) read out by an array of SiPM detectors, multi-pixel photon counters by Hamamatsu, driven by two separate redundant units. To further protect the scintillator block from sunlight and protect the SiPM detectors from particle radiation, we applied a multi-layer structure of Tedlar wrapping, anodized aluminium casing, and a lead-alloy shielding on one edge of the assembly. The setup allows observations of gamma radiation within the energy range of 70–890 keV with an energy resolution of ~30%.

Results. Here, we summarize the system design of the GRBAlpha mission, including the electronics and software components of the detector, some aspects of the platform, and the current semi-autonomous operations. In addition, details are given about the raw data products and telemetry in order to encourage the community to expand the receiver network for our initiatives with GRBAlpha and related experiments.
A Nitsche method for the elastoplastic torsion problem
Authors: Chouly Franz , Gustafsson Tom , Hild Patrick
Published: April 2023

This study is concerned with the elastoplastic torsion problem, in dimension n ≥ 1, and in a polytopal, convex or not, domain. In the physically relevant case where the source term is a constant, this problem can be reformulated using the distance function to the boundary. We combine the aforementioned reformulation with a Nitsche-type discretization as in Burman et al. [Comput. Methods Appl. Mech. Eng. 313 (2017) 362–374]. This has two advantages: (1) it leads to optimal error bounds in the natural norm, even for nonconvex domains; (2) it is easy to implement within most of finite element libraries. We establish the well-posedness and convergence properties of the method, and illustrate its behavior with numerical experiments.
Reportage au cœur du laboratoire souterrain de l’Andra
Authors: Le Gros Gaïc , Bassenne Romain
Published: April 2023

Bienvenue au laboratoire souterrain de l’Andra, une installation en perpétuelle évolution située entre les départements de la Meuse et de la Haute-Marne. Le site, creusé dès l’an 2000, permet de préparer la construction et l’exploitation de Cigéo, le projet français de stockage géologique qui pourrait recevoir une autorisation de création en 2027.
Exploring the integration of Civic Science elements in practical courses--Taking “Electronic Engineering Training 1” as an example
Authors: Li Biqing , Liu Qiuting , Li Yuming , Zheng Shi Yong
Published: April 2023

Practical courses are an important part of the training program for professional talents, and the introduction of thinking and politics education in practical courses is an important direction of the teaching reform of practical courses at the present stage, as well as the need to cultivate students’ comprehensive quality. This paper discusses the current problems of the teaching of practical courses, the positive significance of integrating the elements of thinking and politics into the teaching of practical courses and the principles of integration, and takes “Electronic Engineering Training 1” as the entry point to discuss the ways of integrating the elements of thinking and politics into the teaching of practical courses.
Research on Curriculum Reform of Higher Education Major Based on OBE Education Concept
Authors: Song Beibei
Published: April 2023

As an important venue for continuously exporting talents to China society, universities shoulder the task of adapting to the strategic development needs of China and educating people. However, at this stage, with the acceleration of the popularization of tertiary education, the traditional instructional mode has been unable to meet the new requirements of personnel training. Teaching reform, as an important part of improving instructional level, has been paid more and more attention by universities. Universities are constantly improving themselves in teaching methods, curriculum, personnel training and goal setting, so as to promote the output of compound talents. OBE education concept emphasizes students’ learning achievements and belongs to a new educational concept. Once put forward, it has been highly valued and widely concerned by the education sector, which has guided the correct direction for the pursuit of excellent education in major universities at present. This article introduces the connotation and core elements of OBE education concept; This article analyzes the present situation and existing problems of educational management in universities. On this basis, based on the concept of OBE education, this article puts forward the corresponding strategies to improve the instructional mode in universities, so as to promote the sustainable reform of the courses of education majors in universities, and thus improve the quality of talent training in universities.
Research on Information Literacy Evaluation System of University Teachers
Authors: Ye Lei , Hu Yuqing , Zhang Wanli
Published: April 2023

With the development of educational informatization, the information literacy of college teachers is becoming more and more important, so it is necessary to evaluate the information literacy of college teachers quantitatively. Fuzzy comprehensive evaluation method is a method that synthesizes various influencing factors and transforms qualitative evaluation into quantitative evaluation, which is very suitable for the evaluation of information literacy of teachers in colleges and universities. Based on this, this paper uses fuzzy comprehensive evaluation method to conduct a comprehensive evaluation and analysis of college teachers’ information literacy, in order to provide reference for colleges and universities to improve teachers’ information literacy and promote the construction of education informatization.
Experiment Teaching Reform of Electronic Measurement and Intelligent Instrument Based on Emerging Engineering Education
Authors: Hu Mei , Wang Yongxi
Published: April 2023

In view of the electronic measurement and intelligent instrument of experiment teaching problems, students’ innovative practice ability is vigorously promoted through the establishment of the laboratory, development experimental projects, rich teaching methods, multiple experiment assessment system, practice course education, construction of double type on teachers based on Emerging Engineering Education. It can provide reference for electronic information class other professional courses of Emerging Engineering Education.
A Brief Analysis of Chinese Bamboo Flute Ensemble Art
Authors: Xia Kun
Published: April 2023

Bamboo flute is a traditional Chinese instrument. In the long history of China, the performance of bamboo flute has been used to express and transmit emotions, enriching the spiritual world of the Chinese people. Nowadays, with the continuous progress of spiritual civilization construction and the unprecedented enhancement of Chinese national cultural confidence, the development trend of the bamboo flute art has been more clear. This paper makes an in-depth analysis of the development history and characteristics of bamboo flute ensemble and the significance of its practice, and shares the author’s opinion on the practice of bamboo flute ensemble, so as to enrich the research theory of Chinese bamboo flute ensemble art and make contributions to its development.
Explore the humanistic care in fiber art
Authors: Chen Zhixuan
Published: April 2023

Modern fiber art, as a form of art creation based on people’s psychological feelings, is similar to the concept of humanistic care, which advocates people’s free and all-round development. They are mutually inclusive and interrelated, which not only meets people’s aesthetic needs, but also satisfies people’s spiritual pursuit. With the development of the times, modern fiber art is exploring new art forms, while the concept of humanistic care is more and more valued by people. This paper starts with the study of the relationship between fiber art and human care design, and deeply explores the embodiment and expression of the concept of human care in fiber art, so as to provide more fiber artists with creative inspiration and direction, and promote the development and progress of fiber art.
Research on CAD system design of intelligent clothing accessories based on interactive network
Authors: Xu Shanshan
Published: April 2023

Clothing CAD technology is a bridge that combines clothing design and high technology, and is one of the important fields of computer science and technology in the art kingdom. The style-based intelligent clothing style structure design system studied in this paper is mainly for users or design lovers who are not major in clothing design, so that they can realize the intelligent design of a certain style and style series in the friendly human-computer interaction, thereby replacing the Traditional designer hand creation process. This paper presents the system architecture, designs and completes the interactive interface, analyzes and implements the automatic splicing and adjustment functions of style components provided by the system, and explores and implements style-based style retrieval. Through the overall analysis of the intelligent clothing style structure design system, this paper develops a very good clothing design interface with VC. The author innovatively proposes the idea of “primitive structure” and “function simulation”, and realizes the process of using computer to draw clothing accessories, so that the generated accessories can be accurately fitted along the given curve during clothing design, and provides the interface parameters make clothing accessories adjustable and controllable, which better realizes intelligence and facilitates the use of the client.
The Alienation of Women’s Discourse on Chinese Social Media
Authors: Deng Yichen
Published: April 2023

The burgeoning gendered terms and the derogatory languages that underpin the patriarchy on Chinese social media emerge as an encumbrance to the development of women’s discourse which is plagued with discourse alienation. Given this, this paper reviews the recent research progress into the alienation of women’s discourse on Chinese social media, to manifest the representations of discourse alienation produced by language and to seek possible solutions for constructing healthy women’s discourse. Through analyzing the alienation from the lens of language, this review cites examples in previous research to illustrate how Chinese characters and language relating to women with positive meaning have been derogated, and demonstrates that women’s ways to express in the public sphere are influenced by male-dominated discourse. Three factors conspire to the alienation of women’s discourse, namely the consumerism fueled by Internet communication, the imbalance between the progress of women and ingrained patriarchal culture in the Chinese context, and the passive action taken by women themselves. Major findings were: 1) Chinese-language social media is the breeding ground for the burgeoning gendered terms that stigmatize women’s cohort and muffle women’s discourse; 2) Social media platform perpetuates the patriarchal ideology and consumerism, leading to the alienation of women’s discourse; 3)Women usually plunge into the impasse of men’s discourse by borrowing, imitating and adopting men’s language to express themselves. This paper also indicates the problem of the operation mechanism of social media platform by excessively spreading biased gender representations, which can be addressed with the establishment of a corpora of gender-biased expressions to detect and curb their dissemination.
A Comparison of Female Images in Advertisements Between China and Japan
Authors: Sun Jiaming
Published: April 2023

This paper focuses on the differences and similarities between the images of women in Chinese and Japanese advertisements, analyzes the psychosocial reasons behind the images, and proposes suggestions and outlooks through content analysis and qualitative case studies, using the influential video advertisements of clothing, home appliance, medical beauty care, and vehicles in both countries in the past ten years as research samples. The study found that women in advertisements in both countries are objectified in appearance and rigidified in professional image. The phenomenon of reducing aesthetic bias in Japanese ads came earlier than that in China. However, professional women in China get more respect than those in Japan. With the rapid development of China’s economic society and the increasing status of female subjects, feminist advertisements have grown and tended to be polarized at the same time. Women’s independent personalities should be respected in advertisements. The media should guide the public to get rid of stereotypical perceptions of women, shape a pluralistic image of women, and build a harmonious society.
Long-term Complications of Gluteal Augmentation Using Aquafilling Filler: A Case Report
Authors: Wünscher Sarah Victoria , Cambiaso-Daniel Janos , Gualdi Alessandro , Rappl Thomas
Published: April 2023

The interest in gluteal augmentation using minimally invasive techniques has been increasing rapidly. Despite the fact that Aquafilling filler was described as biocompatible with human tissues, the number of associated complications has been rising.

We present an exceptional case of a 35-year-old female patient, who suffered major long-term complications in association with Aquafilling filler injections in the gluteal region. The patient was referred to our center with signs of recurrent inflammation and severe pain focusing on the left lower extremity. A computed tomography (CT) scan showed multiple, communicating abscess formations all the way from the gluteal region to the lower leg. Therefore, an operative debridement was accomplished in the operating theater.

Finally, this report emphasizes the severity of possible long-term complications when using Aquafilling filler especially in larger areas. Furthermore, the oncogenicity as well as toxicity of polyacrylamide, the core material of Aquafilling filler, remains uncertain, which is why further research is urgently required.
NGS-Panel Diagnosis Developed for the Differential Diagnosis of Idiopathic Toe Walking and Its Application for the Investigation of Possible Genetic Causes for the Gait Anomaly
Authors: Pomarino David , Emelina Anna , Heidrich Jens , Rostásy Kevin , Schirmer Svenja , Schönfeldt Jan O. , Thren Anneke , Wagner Ferdinand , Thren Johanna Ronja , Berger Nina
Published: April 2023

Idiopathic toe walking (ITW) describes a condition affecting approximately 4.5% of children. Toe walking is an accompanying symptom for many hereditary disorders. This retrospective study uses next-generation sequencing-panel-diagnosis to investigate the feasibility of genetic testing to research the possible genetic causes of ITW and for differential diagnosis.

Data were taken from our inhouse database, the minimum age for participants was 3 years. Underlying neurological or orthopaedic conditions were tested for and ruled out prior to diagnosing ITW. Patients, who experienced complications before, during or immediately after birth, children with autism, and patients toe walking less than 50% of the time were excluded.

Eighty-nine patients were included in the study, in which 66 (74.2%) patients were boys and 23 (25.8%) girls. Mean age at testing was 7.7 years (range: 3–17 years). Fifteen of the 89 patients included in the study (16.9%) had a genetic variant identified as likely pathogenic or pathogenic by the genetics laboratory. Additionally, we found 129 variants of uncertain significance. About 65.2% of patients showed a pes cavus foot deformity, 27% of patients reportedly had at least one relative who also displayed the gait anomaly, and 37.1% had problems with their speech development.

Despite the limitations of the sample size and the scope of our genetic testing targets, our results indicate that research into the genetic causes of ITW could better our understanding of the causes of ITW in otherwise healthy children, to help develop novel methods to detect serious conditions early. ITW could be an early onset symptom for further hereditary conditions.