bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential value of left atrial appendage mechanics dispersion for assessing LAA function in patients with Nov-valvular atrial fibrillation
Authors: Wang Li , Zhou BingYuan , Fan Jia Li , Yu Xiangnan , Liao Yuping , Ma ChangSheng
Published: January 2024

Background:Echocardiography is a clinical feasible method of choice for
the quantitative analysis of left atrial appendage (LAA) mechanics in
two dimensions. The study was to assess the potential relationship of
left atrial appendage (LAA) mechanics parameters and left atrial
appendage (LAA) function in patients with non-valvular atrial
fibrillation (NVAF) by two-dimensional transesophageal
echocardiography.Methods:This study involved 216 patients with Atrial
Fibrillation ( 39.4%，woman) who were referred for a clinical
indication for transesophageal echocardiography (TEE).Speckle-tracking
was used to measure left atrial appendage mechanics (LAA) myocardial
strain analysis. Left atrial appendage mechanical dispersions (LAAMD)
were defined as the standard deviation (SD) of time to peak positive
strain corrected by the R-R interval.Results:The Persistent atrial
fibrillation（per-AF）group were older, higher prevalence of stroke, and
more frequently suffered from heart failure than the Paroxysmal atrial
fibrillation（par-AF）group. The patients with a lower LAAEF had less
LAA mechanical dispersion than those with a higher LAAEF
(4.82(2.66~6.82) vs 8.31(5.22~11.85)
,p＜0.05).The LAAMD had a significant positive correlation with the
LAAEF (r=0.455).The LAAEF and LAAMD having the diagnostic performance
(AUC,0.7397,95% CI 0.6692–0.8102, 0.6458, 95%CI 0.5678–0.7239,
respectively). Using a LAAEF cut-off value of ＜64.5% and LAA MD
cut-off value of ＜6.288%, patients with LAA dysfunction were
identified with a sensitivity of 70.45%, 62.96% and specificity of
68.47%, 60.55%, respectively.Conclusions:The data showed that LAAMD
was predictors of dysfunction of LAA, but LAAMD was not superior to
LAAEF in patients for predictors LAA dysfunction. However, Left atrial
appendage mechanical dispersion may showed decreased LAA function before
LAA deformation
COVID-19 pneumonia in a congenital adrenal hyperplasia; a case report
Authors: Saeidinia Amin
Published: January 2024

Congenital Adrenal Hyperplasia (CAH) is managed with long-term
corticosteroid and is suggested to higher dose, based on the general
sick day principles. I presented a 5-year-old CAH case by pneumonia
managed in our pediatrics department. Considering stress doses of
cortisone in management of CAH patients with COVID19 should be
considered.
Usefulness of 3D mapping in catheter ablation of residual AF driver showing fibrillatory activation in isolated SVC.
Authors: Sakaguchi Yuta , Izumi Daisuke , Ikami Yasuhiro , Iijima Kenichi , Minamino Tohru , Inomata Takayuki
Published: January 2024

Ectopic potentials in the SVC can act not only as a trigger but also as
a driver of AF. In the present case, the atrium resumed a sinus rhythm
spontaneously on the completion of SVC isolation and AF could no longer
be induced. However, there was residual fibrillatory activity in the
SVC. These findings suggest that residual activity in the SVC worked as
a driver of AF. In the presence of a fibrillatory pattern, conventional
activation mapping techniques cannot map residual SVC activity. ICL
mapping using the CARTO system can identify the target site of ablation
in the isolated SVC.
The Interleukin 6 (IL-6) blockade for coronavirus disease 2019 (COVID-19) In Lung
Authors: Rao Zhili , Zhou Hongli , Li Xiangyu , Zeng Nan
Published: January 2024

COVID-19 has caused global pandemics since the emergent outbreak and
resulted in a large number of deaths. IL-6, as an important autoimmune
cytokine, had been suggested for the treatment of acute respiratory
distress syndrome (ARDS) patients in COVID-19. A review of the relevant
literature revealed more than one role for IL-6 in the lung infection
because of its diverse biological effects. It may have a variety of
different physiological functions in the development of lung infection.
We have summarized its role in different progress of COVID-19, including
lung infection, pneumonia, ALI, pulmonary fibrosis, and lung translation
and even lung cancer. This will facilitate a deeper understanding of the
role of IL-6 in the treatment of COVID-19.
A review of the management of fungal otitis externa with necrosis of the tympanic membrane: An additional of 2 cases to the literature.
Authors: Abbas Yasmin , Patel Nitesh
Published: January 2024

• A high index of suspicion is needed when otitis externa not improving
and there are symptoms of significant pruritis. • Signs of fungal
debris, either obvious spores or black particles in debris should alert
one to take a microbiology swab for fungal culture, which may yield
Candida or Aspergillus species. • Treat patients with regular and prompt
microsuctioning and application of topical antifungals for up to a
month: Aspergillus can be particularly aggressive and lead to tympanic
membrane erosions, ulceration and perforation. • Flumetasone/Clioquinol
drops are effective in Aspergillus fungal otitis externa • Consider
surgical repair if tympanic membrane not healed with medical treatment.
The Distribution of Career Anchor Types and Psychological Capital Analysis of Newly Graduated Nurses
Authors: wu xiaoying , zhou yuhua , ying wenjuan
Published: January 2024

Background: At present, the global shortage of nurses is prominent. No
research prove whether nursing managers can prevent the loss of nurses
according to the characteristics of nurses’ occupational anchor types
and their psychological capital level. Objective: To investigate the
distribution of career anchor types and the status quo of psychological
capital of newly graduated nurses and to analyze the influencing
factors. Methods: 484 nurses graduated within 3 years from 5 public
general hospitals were selected by convenience sampling. Career anchor
and psychological capital questionnaire were used to investigate.
Results: 481 valid questionnaires were collected. Career anchor type
distribution is the most Secure /Stable, accounting for 48%, General
Managerial Competence is the least, only 1.9%, psychological capital
score of the Challenge type nurse is the highest (P<0.05). The
residence and singleness of new graduated nurses were the influencing
factors of Career capital score (P < 0.05); The age, single
status, education background and residence of newly graduated nurses
were the influencing factors for the classification of career anchor (P
< 0.05). Conclusion: nursing managers can arrange appropriate
nursing posts according to the characteristics and psychological capital
level of different types of career anchor nurses to establish a stable
nursing team.
The association between diet quality scores with sleep quality among employees: A cross-sectional study
Authors: behbahani Hossein bavi , Borazjani Fatemeh , sheikhi leila , Amiri Rezvan , Angali Kambiz Ahmadi , Nejad Sudabeh Basak , Samadani Mahsa
Published: January 2024

Background: Various studies show that the quality of sleep, in employees
can be effective in improving the quality and performance of their work.
Numerous factors such as nutrition and diet can affect the quality of
sleep of people, especially employees. This study was performed to
investigate the relationship between food quality scores (HEI, DII and
DASH score) and sleep quality in employees. Materials and methods: The
present cross-sectional study was performed on 211 employees with a mean
age of 38.75±11.31. Nutritional status of individuals was determined
through the Food Frequency Questionnaire (FFQ) and to assess sleep
quality, the Pittsburgh Sleep Quality Index (PSQI)was used which
contains questions about delay, duration, sleep effectiveness, sleep
disorders, sleeping pills and daily dysfunction. The quality of sleep
decreases with increasing Pittsburgh index score. The calculated dietary
quality scores include DASH Dietary Adherence Index, Healthy Nutrition
Index (HEI) and Diet Inflammation Index (DII). Results: The results of
this study after adjusting for confounding factors including age, sex,
daily energy intake and BMI showed a significant positive relationship
between DASH diet score and sleep duration (p <0.001). There
was a significant negative relationship between HEI score and total
score of Pittsburgh Sleep Quality Index (P = 0.003). Also, HEI score had
a significant positive relationship with sleep duration in the
unmodified and modified models (p <0.001), and a significant
negative relationship was seen in unadjusted and modified model between
DII score and sleep duration (p <0.001). Conclusion: DASH and
HEI score had a significant positive relationship with sleep duration
and DII had a significant negative relationship with sleep duration. HEI
also significantly improved sleep quality.
Strang time-splitting technique via lumped Galerkin method based on cubic B-splines for the Benjamin-Bona-Mahony-Burgers Equation
Authors: karta melike
Published: January 2024

In the present manuscript, we are going to research a numerical scheme
of the nonlinear Benjamin-Bona-Mahony-Burgers (BBMB) equation using the
Strang time-splitting technique based on cubic B-spline lumped Galerkin
method. In line with our aim, this equation is split into two
sub-equations containing the derivative in time direction. Each
sub-equations is applied Galerkin finite element method with cubic
B-splines and after that the resulting equations are solved with the
Strang time-splitting technique. Stability analysis of numerical
algorithm is investigated. Five test problems with both exact solution
and not is suggested to test the accuracy and reliability of the
presented method. The error norms $L_{2}$ and
$L_{\infty}$ with three invariants
$I_{1},I_{2}$ and $I_{3}$ are computed and compared with
existing studies in the literature and the obtained numerical results
are displayed in graphics as well as tables. The numerical results
obtained with this new approach set light to the solution of nonlinear
equations as an effective mathematical tool.
BLOCKCHAIN-ENABLED SAFETY MANAGEMENT ARCHITECTURE FOR CLINICAL TRIALS
Authors: Barenji Reza Vatankhah , Harir Reza Ebrahimi
Published: January 2024

Clinical trial participants are a vital part of drug development
research and there are many rules to help and ensure the safety and
ethics of clinical trials. Managing patient safety during clinical
trials is a critical component throughout the drug development
life-cycle. As the first step towards ensuring patient safety, all the
involved parties in drug development need to be respectful and
responsive towards patient’s needs, comfort, and preferences i.e.
ensuring a patient-centric approach. In this paper blockchain technology
is embedded in the Quality by Design (QbD) systematic approach to boost
data integrity among the activities, and to promote participants’ safety
in clinical trials. First, blockchain-enabled QbD architecture is
proposed and the interactions among the enablers and peers are
highlighted. Then, a prototype of the proposed architecture is developed
and the data of a pilot trial is used to justify the applicability of
the architecture. The results showed that the proposed architecture is
efficient, and hence it is feasible to adopt into a clinical trial.
Electrical Storm in a patient with Brugada Syndrome and COVID-19 infection
Authors: Ali Syed , Nilsson Kent
Published: January 2024

Brugada syndrome is an inherited arrythmia syndrome characterized by a
right bundle branch block and dynamic ST-segment changes in precordial
leads V1-V3. In patients with Brugada syndrome, fever is a known trigger
that may induce arrythmia. For patients with Brugada syndrome who
contract COVID-19, the inflammatory response poses risk of causing
ventricular arrythmias. The following case discusses management of a
patient with Brugada syndrome presenting with electrical storm after
contracting COVID-19. Treatment should be focused on aggressive
antipyretic management along with concomitant pharmacological therapy.
Differences in the success of prenatal diagnosis of birth defects associated with singleton and multiple pregnancies: an observational study of more than 1.9 million births in Zhejiang Province, eastern China, during 2012–2018
Authors: Zhu Shankuan , Chen Lijin , Wen Hong , Lou Haifeng , Kang Qingcong , Chen Xinning , Chen Danqing , Zhang Xiaohui
Published: January 2024

Objective: To characterize differences in the prenatal diagnosis of
birth defects (BDs) associated with singleton and multiple pregnancies.
Design: An observational study conducted using data from a BDs
surveillance system. Setting: Eastern China. Population: A total of
54,572 babies with BDs, born in 90 hospitals located in 30 regions of
Zhejiang Province between 2012 and 2018. Methods: BDs were diagnosed by
obstetricians using ultra sonographic, genetic tests et al., on the
basis of the ICD 10th Revision (Q00–Q99). Main outcome measures:
Differences in incidence and characteristics of BDs associated with
singleton and multiple pregnancies. Multivariate logistic regression
models were constructed to characterize relationships between the
prenatal diagnosis of BDs and multiple pregnancies, with adjustment for
covariates. Results: Totals of 49,872 singletons and 3,324 multiple
pregnancies with BDs were analyzed. The mean incidences of BD for single
and multiple pregnancies were 26.29 and 109.99 per 1,000 births,
respectively (χ2=7600, P<0.001). After adjustment for
covariates, BDs associated with multiple pregnancies were less likely to
be diagnosed prenatally (adjusted OR: 0.36, 95% CI: 0.32–0.40); as
were congenital heart defects, congenital hydrocephalus, cleft lip with
cleft palate, congenital talipes equinovarus, cleft lip without cleft
palate, limb reduction defects, congenital diaphragmatic hernia, trisomy
21 syndrome, congenital malformation of the urinary system, and other
chromosomal malformation, compared with singletons with BDs.
Conclusions: Multiple pregnancy is associated with a significantly
higher risk of BD, but a significantly lower prenatal diagnosis rate.
Therefore, the healthcare of women with multiple pregnancy and their
fetuses should be strengthened.
T-cell Immunity Against COVID-19 and UK Variant in Infected and Vaccinated Individuals
Authors: Jordan Stanley , Shin Bong-Ha , Milfordgadsden Terry-Ann , Chu Maggie , Petrosyan Anna , Le Catherine , Zabner Rachel , Oft Jillian , Pedraza Isabel , Ammerman Norkio , Cheng Susan , Vo Ashley , Plummer Jasmine , Berg Anders , Ge Shili , Toyoda Mieko , Zhang Ruan
Published: January 2024

Understanding the composition of human immune responses to SARS-CoV-2
and vaccines is essential for predicting protection from infection and
determining vaccine efficacy. Here, we explored T-cell immune responses
to SARS-CoV-2 and the UK (B.1.1.7) variant of concern (VOC) in infected
and vaccinated individuals. In infected patients, CD4+ T-cells
demonstrated consistent, robust responses against Spike peptides, while
CD8+ T-cells had heterogeneous responses to 5 SARS-CoV-2 proteins. We
found 80% of infected and vaccinated individuals showed positive CD4+
T-cell immunity against SARS-CoV-2. Moreover, CD4+/CD8+ T-cell responses
to SARS-CoV-2 and the United Kingdom (B.1.1.7) variant are robust and
nearly identical in infected and vaccinated individuals. Thus, the UK
variant did not interfere with T-cell recognition and elicited
responses. These observations will be of critical importance in
assessing human immune responses to emerging VOCs.
Middle-Power Middle-Duration versus High-Power Short-Duration Radiofrequency Ablation in Pulmonary Vein Isolation with Lesion Size Index-guided Strategies
Authors: Mase Hiroshi , Onuki Tatsuya , Mori Hiroyoshi , Arai Shuhei , Nakamura Yuya , Kurata Masaaki , Wakatsuki Daisuke , Asano Taku , Suzuki Hiroshi
Published: January 2024

Introduction Pulmonary vein isolation (PVI) is an established treatment
for atrial fibrillation (AF), and high-power, short-duration (HP-SD)
radiofrequency ablation has been reported to be effective. Since the
depth of the myocardial scar created by HP-SD ablation can be shallower
than that of conventional middle-power, middle-duration (MP-MD)
ablation, which might be a partial limitation of HP-SD ablation, we
investigated the differences between HP-SD and MP-MD ablation. Methods
and Results A total of 158 patients who underwent lesion size
index-guided PVI were enrolled. The first half of the consecutive
patients (n=83) underwent MP-MD ablation, while the second half (n=75)
underwent HP-SD ablation. The PVs on both sides were divided into six
segments of anterior, posterior, roof, bottom, and on the anterior and
posterior of the carina. The patient characteristics, procedure
features, remnant and early reconnections (RERs) of PV conduction after
initial PVI, and clinical outcome were compared between the groups. The
procedure time was significantly longer in the MP-MD group than in the
HP-SD group (176.9 ± 56.0min vs. 132.1 ± 45.9min, respectively,
p<0.001). The rates of RER at the right anterior carina was
significantly less frequent in the MP-MD group than in the HP-SD group
(12.1% vs. 25.3%, respectively, P=0.04). The cumulative recurrence
rate expressed in the Kaplan-Meier curve was comparable between the
MP-MD and HP-SD groups. Conclusions Each method showed distinguished
features. Combination use of MP-MD and HP-SD depending on the segment of
the PV, especially the right PV anterior carina, may be reasonable.
A Persian herbal formula (Triphala) for male infertility; a case report
Authors: Jaladat Amir Mohammad , Taherifard Erfan , Sadeghi Alireza , Pasalar Mehdi
Published: January 2024

We are reporting the therapeutic effect of a Persian herbal formula
(Triphala) on male infertility. A 27-year-old man was diagnosed with
male infertility based on sperm analysis and World Health Organization
(WHO) manual for semen analysis. Over three months, the patient was
treated with a Persian herbal preparation named Triphala.
Serum tumor abnormal protein examination contributes to the diagnosis of lung cancer
Authors: Luo Shoujun , Zheng Xu , Wang Linfeng , Huang Weina , Hu Jing
Published: January 2024

Background: Serum tumor abnormal protein (TAP) level has been confirmed
to be associated with the progress of tumor cells. Objective: This study
aimed to investigate the diagnostic value of TAP in lung cancer
patients. Methods: 159 patients with lung cancer and 45 patients with
benign pulmonary nodules were enrolled in this study. We measured serum
TAP level and explored the relationship between TAP level and disease.
Results: Serum TAP level of lung cancer patients were higher than that
in benign diseases (123.4±45.4µm2 versus 104.2±25.4 µm2, P=0.0073). The
results showed that TAP levels were reliable in distinguishing lung
cancer from benign diseases with an area under the curves (AUC) value of
0.6222 (95% CI, 0.5360-0.7083). In addition, we observed that TAP level
were associated with the pathological classification of lung cancer. The
AUC values for ADC, SCC and SCLC were 0.6031(95%CI, 0.5110-0.6952),
0.6656(95%CI, 0.5373-0.7939) and 0.8089(95%CI, 0.5531-1.065),
respectively. Conclusion: TAP might be a valuable biomarker for the
diagnosis of lung cancer.
Revisiting the impact of drought over the mid-continent USA from 2000-2019 using High-resolution data
Authors: Mbuh Mbongowo
Published: January 2024

Drought-associated water shortage a complicated hazard, and extreme
weather and climate events have serious impacts on agricultural,
ecological, and socio-economic activities in any society. Several
drought indices have been developed over the past decades for assessing
the scope, start, duration, and intensity of drought. This work focuses
on drought analysis using a high-resolution remote sensing and
meteorological dataset from MODIS’ NDVI and LST to evaluate the
Spatio-temporal distribution drought events and intensities in three
physiographic regions of the USA from 2000 – 2019. Results were
compared with other remote-sensing-based drought indices, such as the
temperature condition index (TCI), Vegetation Health index (VHI), and it
was observed that the VCI and VHI, which was a combination of vegetation
and meteorological information, had a strong correlation with
precipitation data than the NDVI-derived VCI. The results demonstrated
the severity of vegetation stress and extreme droughts in 2000, 2006,
2011, and 2012. The long-term agricultural drought situation and
compared with other drought indices, reveals a good agreement as to the
TCI, VHI, and precipitation anomalies also decreased significantly.
MiRNA-122 promotes ischemia-reperfusion injury after lung transplantation via the TLR signaling pathway
Authors: Lu Yuan , Wang Yali , Liu Quan , Zhou Peng , Mei Peiyuan , Li Jinsong , Zheng Zhikun
Published: January 2024

Background: MiRNAs have been recently implicated in the pathogenesis
underlying ischemia-reperfusion (IR) injury. We investigated the miRNAs
expression profiles in the early stages after lung transplantation (LT)
and studied the involvement of Toll-like receptor(TLR) signaling pathway
in lung IR injury following LT. Methods: We established the left LT
model in mice, The mice were injected with a miRNA-122 specific
inhibitor, following which pathological changes in the lung tissue were
studied using different lung injury indicators. In addition, we
performed deep sequencing in transplanted lung tissues to indentify
differentially expressed (DE) miRNAs and their target genes. Results: A
total of 12DE miRNAs were selected and 2,476 target genes were
identified; The gene ontology (GO) enrichment analysis predicted 6,063
terms and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis
predicted 1,554 biological pathways. Compared with the control group,
inhibiting the expression of miRNA-122 significantly reduced the lung
injury and lung W / D ratio (p<0.05). In addition, the
activity of myeloperoxidase (MPO) and expression of tumor necrosis
factor (TNF)-α and TLR2/4 decreased (p<0.05); whereas the
expression of interleukin-10(IL-10) expression levels increased
(p<0,05). Furthermore, the inhibition of miRNA-122 suppressed
the IR injury-induced activation of the TLR signaling pathway.
Conclusions: Our findings showed the differential expression of several
miRNAs in the early inflammatory response following LT. Of these,
miRNA-122 promoted the IR injury following LT, whereas its inhibition
prevented IR injury in a TLR-dependent manner.
Dynamics of a modified Leslie-Gower predator-prey model with linear harvesting
Authors: Ye Juan , Dai Chuanjun , Zhao Min
Published: January 2024

In this paper, a modified Leslie-Gower predator-prey model with strong
Allee effect and double harvesting was studied analytically and
numerically. The aim of the research is to provide an understanding of
the impact of harvesting on the predator-prey model. The existence and
stability of the equilibria was discussed, and we analyzed the existence
of some bifurcations, such as saddle-node bifurcation, Hopf bifurcation
and Bogdanov-Takens bifurcation. Furthermore, some numerical simulations
were proposed to illustrate the dynamics of the model. Numerical results
are consistent with the analytical results.
Juvenile Temporal Arteritis with ocular involvement and excellent response to temporal artery excision
Authors: Carvalho Jozelio Freire de , Churilov Leonid , Lopes Jahilton , Silva Marcelo
Published: January 2024

Background: Juvenile temporal arteritis (JTA) is a rare manifestation of
TA before 50-year- old. Objective: To describe a patient with juvenile
temporal arteritis (JTA) and ocular involvement and excellent response
to temporal excision. Case report: A 41-year-old male patient with an
unmarked past medical history pain in his right eye with no change in
visual acuity and sensitivity on the right cephalic temporal area. An
angio-magnetic resonance imaging revealed a hyper signal on the right
ophthalmic artery compatible with retinal vasculitis. Prednisone
40mg/day for 3 months was started, and no change in pain was noted.
Laboratory tests were normal, except for antinuclear antibodies positive
in a titer of 1:160 and a nuclear dense fine speckled pattern, with
positive anti-LEDGF75 antibodies. A diagnosis of JTA was determined. A
temporal artery was performed, with normal histology. After surgery, all
symptoms disappeared. Conclusion: This article describes an additional
JTA case who was successfully treated after temporal artery
biopsy/excision.
Temperature indices for a Non-Kekulean benzenoid graph
Authors: Liu Jia-bao , Ghani Muhammad , KHAN ABDUL RAUF , Cancan Murat , Asif Hafiz Muhammad
Published: January 2024

A molecular descriptor, also known as a topological graph index, is a
mathematical formula that may be implemented to any network that
reflects a molecule structure. This index can be used to explore some
physical aspects of a molecule and examine mathematical values. As a
consequence, it is a better solution for costly and time-consuming
laboratory experiments. In this work, we calculate the first temperature
index, the second temperature index, the first hyper temperature index,
the second hyper temperature index, the sum temperature index, the
product temperature index, the reciprocal product temperature index and
the $F$-temperature index. These defined indices are computed for the
Non-KuKulean benzenoid graph.
His Bundle Pacing Combined With Atrioventricular Node Ablation-A Novel Treatment of Atrial Fibrillation Patients With Heart Failure
Authors: Luo Xinmiao , Zhang Lu , Huang Chaoqun , Li Shuyan
Published: January 2024

Atrial fibrillation patients with heart failure often have the worst
prognosis. Pacing combined with atrioventricular node ablation (AVNA) is
often the last resort in patients with atrial fibrillation (AF) and
heart failure (HF) who are refractory to medication therapy or AF
catheter ablation, especially in those with other arrhythmias that need
pacemaker therapy. His bundle pacing is a physiologic pacing option for
patients undergoing AVNA, which prevents the adverse consequences of
right ventricular pacing and enhances the response rate compared with
biventricular pacing (BVP). Several studies have proven the clinical
benefits, feasibility and efficacy of His bundle pacing combined with
atrioventricular node ablation in patients with AF and HF. However, this
must be confirmed in large randomized clinical trials. Due to HBP
limitations of difficulty in implantation, lower success rates in
patients with QRS prolongation, and high and unstable pacing capture
threshold, the concept of left bundle branch pacing has been proposed in
recent years. In this review, we discussed the epidemiology of atrial
fibrillation and heart failure, their interrelations, current treatment
for patients with AF and HF and focus on the role and current evidence
for His bundle pacing combined with atrioventricular node ablation in
patients with AF and HF.
Multiple-omics techniques reveal the difference between polyphagous Conogethes punctiferalis and oligophagous C. pinicolalis
Authors: Jing Dapeng , Prabu Sivaprasath , Zhang Tiantao , Bai Shuxiong , He Kanglai , Zhang Yong-Jun , Wang Zhenying
Published: January 2024

Although Conogethes punctiferalis and Conogethes pinicolalis have
reported on morphology and molecular identification, the molecular
biology differences between the two species in different diets are still
unknown. In this work, we investigated the difference in the biological
process of the two species by the methods of transcriptomics,
proteomics, metabolomics, and bioinformatics. The results showed that
the expression of 74,611 mRNA in the transcriptome, 391 proteins in the
proteome, and 218 metabolites in the metabolome had been significantly
changed between the two species, and the KEGG results showed the data
were mainly closely related to metabolism and redox. Moreover, based on
integrating system-omics data, we found that the α-amylase and CYP6AE76
gene have mutations between the two species. Different sequence analysis
results may differ significantly in their exact substrate preference and
product profile, which indirectly leads to the different detoxification
or metabolism ability, and the gene expression of relevant was also
confirmed by the qPCR and enzyme activity test. These findings in the
two species and integrated networks provide beneficial information for
further exploring the molecular mechanism of polyphagous and
oligophagous.
Clinical features and image manifestations of recurrent retinoblastoma with limb bone metastasis and without CNS involvement
Authors: Gu Huali , Wang Zhuo , Huang Dongsheng , Ji Xunda , Zhang Yi , Ma Jian-Min , Zhang ling , Hu Hui-Min , Zhang Pinwei , Yi You
Published: January 2024

Background: Retinoblastoma (RB) is the most common intraocular
malignancy in infancy and childhood. Bone metastases are common and
usually involve the skull and axial bones; limb bone metastases are
rare. Herein, we evaluated the clinical features, image manifestations,
treatment, and prognosis of patients with recurrent RB with limb bone
metastasis and without central neural system involvement. Procedure:
Clinical data of 5 patients with retinoblastoma who were diagnosed at
the Department of Pediatrics in Beijing Tongren Hospital, between
January 2015 and January 2021, were retrospectively analyzed. Results:
Three males and two females were included (7 eyes: 4 stage E and 1 each
of stage D, C, and B). The interval between symptom onset and bone
metastasis was 12-102 months. Three cases were unilateral (2 left and 1
right), and two were bilateral. The most common symptom was pain. Three
patients had bone marrow and lymph node metastasis. Three patients had
single and two had multiple skeletal lesions. The main limb bones
involved were the femur, humerus, talus, and ulna. Serum neuron specific
enolase (NSE) was significantly elevated in 4 cases, and slightly
elevated in 1 case; primary intravenous chemotherapy resulted in a
decrease in NSE and gradual resolution of bone lesions. At the time of
follow-up, 2 patients died and 3 were in complete remission.
Conclusions: Regular lifelong follow-up of patients with RB is warranted
to identify bone metastases. Clinicians should consider examination
findings, imaging findings, and laboratory results to identify bone
metastases and initiate appropriate treatment.
Study on Synthesis of 9,9-bis(hydroxymethyl)fluorene and Its Application for Separating Phenanthrene from Fluorene
Authors: Ye Cuiping , Liu Junli , Guo Meixin , Qiao Yafei , Wang Ruinan , LI Wenying
Published: January 2024

To realize the separation of phenanthrene from anthracene residue
efficiently, a reaction–separation coupling technology was adopt by
converting fluorene to its valuable derivative, and then phenanthrene
was isolated according their solubility difference. The effect of
solvents, feeding sequence and the material ratios on the synthesis of
9,9-bis(hydroxymethyl)fluorene by one-step hydroxymethylation of
fluorene was investigated firstly, and then the reaction–separation
process conducted with a mixture of phenanthrene and fluorene at a mass
ratio of 4:1. The result showed that adding fluorene into alkaline
formaldehyde solution can improve the selectivity of
9,9-bis(hydroxymethyl)fluorene, and with the mixture of DMSO and ethanol
as solvent, the highest yield of 84.24% is obtained by using anhydrous
potassium carbonate as base catalyst. The reaction applied for the
mixture of phenanthrene and fluorene, the purity of
9,9-bis(hydroxymethyl)fluorene of 87.26% was obtained with a yield of
73.87%, and the yield of phenanthrene is 98.96% with a purity of
97.18%.
New SARS-CoV-2 variants accumulate positive electric residues in the crucial regions of spike glycoprotein S
Authors: Pawłowski Piotr
Published: January 2024

In the monthly reported by the European Centre for Disease Prevention
and Control virus variants, the increasing tendency in the number of
positively loaded residues was observed. The formal charge of 34
SARS-CoV-2 lineages since September 2020 to June 2021 was analyzed. The
point mutations or small insertions were considered in the crucial for
viral infection regions of the spike glycoprotein (S). The most
frequently observed were positive mutations, especially D614G and E484K,
located in the region of S1/S2 junction, and in the receptor binding
domain (RBD), respectively.
An Audit of the Head Up Tilt Table Test at a Tertiary Care University Hospital
Authors: Zafar Rizwan , Saleem Muhammad Asad , Niazi Asfandyar , Ahmad Arsalan , Naseer Aamir , Khan Danish
Published: January 2024

Syncope is a self-limiting transient loss of consciousness (TLOC) caused
by cerebral hypo-perfusion, which can be classified into orthostatic,
cardiac, or vasovagal etiologies on the basis of tilt table test. We
conducted a single-center retrospective chart review study of patients
above 16 years of age who underwent HUTT testing from January 2010 to
March 2020. Charts were reviewed for basic demographic data and
indication and outcome of test. Correlation of age, gender, and
presenting symptoms with results of HUTT test were analyzed. Our study
included 496 patients with 72.2% males and mean age of 51.1 years.
Vasovagal syncope was found to be the most common etiology (79.8%,
n=158), followed by orthostatic syncope (11.6%, n=23), autonomic
syncope (6.1%, n=12) and postural orthostatic tachycardia syndrome
(2.5%, n=5). Vasovagal syncope was further divided into three subtypes,
with most common being mixed type (82.3%,n=130), followed by pure
vasodepressor (14.6%, n=23) and cardio-inhibitory(3.2%,n=5). The two
most common prodromal symptoms were loss of consciousness (45.8%,
n=227) with or without preceding dizziness followed by dizziness alone
(34.5%, n=171). Both of these symptoms had a statistical significance
when compared to the diagnostic yield of HUTT testing (p value
<0.05). No significant correlation (p value
>0.05) was found between the presenting symptoms, age,
gender and outcomes on HUTT testing. We concluded that the most common
etiology of syncope is vasovagal, predominantly the mixed type. LOC and
dizziness were found to be statistically significant in relation with
the yield HUTT testing.
Pharmacogenomics for the efficacy and side effects of antihistamines
Authors: Li Liqiao , Liu Runqiu , Peng Cong , Chen Xiang , Li Jie
Published: January 2024

Antihistamines are widely used in allergic diseases such as urticaria
and allergic rhinitis, mainly by reverse excited histamine and
anti-allergic effects. Antihistamines are generally safe, but there may
be some adverse reactions like cardiotoxicity, central inhibition,
anticholinergic effects, etc. And there are also individual differences
in clinical practice. The concept of individualized medicine has been
deeply rooted in people’s minds since it was put forward. In recent
decades, pharmacogenomics has been developing rapidly, which provides
new ideas for the occurrence of individual medication. Gene polymorphism
in the metabolic enzyme, transports, and target receptors have been
shown to affect the application of antihistamines. Besides, recent
evidence suggests that genetic polymorphisms influence urticaria
susceptibility and antihistamine therapy. Here, we summarize current
reports of this area, aim to contribute to the future research and
clinical guidance of antihistamine personalized medicine.
Correlation between the location of the ventricular outflow tract arrhythmia with left ventricular intrinsic systolic function in patients without structural heart disease
Authors: Alexander Tommy , Hanafy Dicky , Raharjo Sunu , Ariani Rina , Meidian Ade , Hermanto Dony
Published: January 2024

Background: Study showed that a lower PVC burden originating from the
right ventricle was able to decrease left ventricular function compared
to PVC burden originating from the left ventricle (≥10% vs ≥20%). In
addition, animal studies have shown differences in the degree of
fibrosis due to arrhythmias in the left ventricle compared to the right
ventricle. Objective: evaluate the association between location of VOT
arrhythmia to intrinsic left ventricular systolic function in patient
without structural heart disease Methods: This is a cross-sectional
study in 36 ventricular outflow tract arrhythmia patients assessed by
V2QRSi40 electrocardiogram criteria with PVC burden ≥4% in National
Cardiovascular Center Harapan Kita (NCCHK) from February 2021 to May
2021. Intrinsic left ventricular systolic function assessed by global
longitudinal strain (GLS) with speckle tracking echocardiography (STE).
Statistical analysis was conducted to evaluate the association between
origin of VOT (right VOT vs left VOT) and GLS. Results: Of the 36
subjects, the proportion of female sex was higher than that of men
(72.2% versus 27.8%), with the mean GLS score in women being higher
than in men (–20,5±4,3 vs. -17,7±3,3, p=0.072). Patients with
non-sustained VT episodes had a lower mean GLS score than those without
(-15,5±3,1 versus -20,6±4,0, p<0.05). The location of the
ventricular outflow arrhythmias was not associated with GLS values
either by bivariate analysis or multivariate analysis [p=0,843;
coefficient B (CI95%) = -0,036 (-3,441 - 2,832)]. Conclusion:
Location of VOT arrhythmia was not associated with intrinsic left
ventricular systolic function in patient without structural heart
disease
Impact Of Subclinical Hypothyroidism Treatment During Pregnancy on The Maternal Outcomes: A Retrospective Case-Control Study
Authors: Mirzamoradi Masoomeh , Habibzadeh Zahra , Parsa Yekta , Motavvef Maha , Jamali Marzieh
Published: January 2024

Objective: Subclinical hypothyroidism may cause complications during the
pregnancy. The effect of subclinical hypothyroidism treatment during
pregnancy is unknown. The main challenge is to determine an upper limit
in which women might experience negative pregnancy outcomes. This study
was conducted to assess the subclinical hypothyroidism treatment
prognosis in pregnant women in an obstetrical tertiary referral center.
Design: A retrospective case-control study Setting: This study was
conducted from 2015 to 2019 in a tertiary obstetrical referral center in
Iran, Tehran. Population: The patients who were referred to obstetrical
clinics for prenatal care entered the study. Methods: A questionnaire
was filled for each patient consisting of detailed information about the
patients. The patients were followed up until labor and all pregnancy
outcomes were noted. The results were compared using SPSS 24 and the
P<0.05 was considered the significance level. Result: A total
number of 155 patients with the mean age 28.74±5 was referred to the
clinic. 80 patients were in the case group while in the control group
there were 42 pregnant women. There was a statistical difference between
patients positive for Anti-TPO and negative ones (P<0.05).
Conclusion: Though there was a significant difference in the TSH level
between the two groups, the pregnancy outcomes did not differ among
patients. Although the necessity of treatment in this clinical condition
is still controversial, it might reduce some neurological damages in
neonates and pregnancy complications in mothers.
Bounding Pandemic Spread By Heat Spread
Authors: Lazebnik Teddy , Itai Uri
Published: January 2024

The beginning of a pandemic is a crucial stage for policymakers. Proper
management at this stage can reduce overall health and economical
damage. However, knowledge about the pandemic is insufficient. Thus, the
use of complex and sophisticated models is challenging. In this study,
we propose analytical and stochastic heat spread-based boundaries for
the pandemic spread. These are compared with the stochastic
Susceptible-Infected-Recovered (SIR) model taking place on an
interaction graph. The proposed boundaries are not requiring accurate
biological knowledge such as the SIR model does.
The relationship between monocyte to high-density lipoprotein cholesterol ratio and coronary microvascular disease
Authors: li Fengxiang , Shan Yingguang , Gao Jinghong , Guo Yuxi , Dou Min , Qin Xiaofei
Published: January 2024

Abstract Background: The monocyte to high-density lipoprotein
cholesterol ratio has emerged as a novel inflammatory marker in the
fields of cardiovascular disease. To explore the relationship between
monocyte to high-density lipoprotein cholesterol ratio(MHR) and the
occurrence of coronary microvascular disease(CMVD). Methods: 289
patients with angina symptoms and no obvious obstructive coronary
arteries were enrolled in our hospital from September 2019 to June 2021.
CMVD was diagnosed by coronary flow reserve (CFR). According to the CFR,
158 patients in CMVD group(CFR≤2), 131 patients in non-CMVD
group(CFR>2). The differences in baseline clinical
characteristics and MHR between the two groups were compared. And the
significative influencing factors of CMVD were analyzed by multivariate
Logistic regression. The operating characteristic curve(ROC) was drawn
to evaluate the predictive of influencing factors. Results: Compared
with NO-CMVD group, triglyceride, monocyte count , MHR, blood platelet
was significantly increased in CMVD group(p<0.05), but
high-density lipoprotein cholesterol was decreased in CMVD
group(p<0.05). From multivariate logistic regression analysis,
MHR, monocyte count and high-density lipoprotein cholesterol were all
independent factors for patient.(p<0.01). ROC curve showed
that the area under ROC curve of MHR in predicting CMVD was
0.738[95%CI为（0.679，0.794）. MHR can be better in predicting the
occurrence of CMVD. Conclusion: MHR was shown to be an independent risk
factor associated with the occurrence of CMVD. And it also can well
predict the occurrence of CMVD.
Alteration of gut microflora and role of gut dysbiosis in modulation of gastrointestinal toxicity in pediatric cancer patients
Authors: Sahoo Debasish , Bamola V. Deepak , Gupta Aditya , Meena Jagdish , Naranje Priyanka , Dwivedi Sadanand , Ahuja Vineet , Chaudhry Rama , Seth Rachna
Published: January 2024

Background Chemotherapy related mucosal toxicity is a major hindrance to
successful therapy in pediatric cancers. The role of gut dysbiosis in
modulation of chemotherapy related gastrointestinal toxicity is poorly
understood. Methods Pediatric cancer patients with neutropenia and
gastrointestinal symptoms were evaluated for neutropenic enterocolitis
(NEC) with CECT abdomen. Clinical features, fecal calprotectin and
microbiological data were analysed. Fecal Gut microbiota was evaluated
in children with NEC and compared with children where NEC was excluded
and healthy controls using conventional culture method. Results Of 590
children receiving chemotherapy during study period, 44 were diagnosed
with NEC. Significantly higher frequency of isolation of Bacteroides was
observed in children with NEC (42%) as compared to non- NEC group
(14%) and healthy controls (13%). Isolation of Lactobacilli was
infrequent in NEC group (26%) than non- NEC group (74%) and healthy
controls (80%). There was nonsignificant trend towards higher isolation
of Clostridium in children with NEC. Clostridiodes difficle or
Clostridium septicum were not identified in any group. Isolation of
other bacterial flora was similar in the sub groups. No significant
association of survival with gut dysbiosis could be established.
Isolation of Lactobacilli was associated with reduction in duration of
intravenous alimentation by 2.4 days, whereas isolation of Bacteroides
prolonged the requirement of bowel rest by 2.2 days. Conclusion Gut
dysbiosis was significantly higher in NEC group and associated with
higher morbidity suggesting its role in pathogenesis. This highlights
role of interventions towards gut dysbiosis like prebiotics and
probiotics in pediatric cancer patients.
A uniqueness result for the fractional Schr\”odinger-Poisson system with strong singularity
Authors: wang li , Zhong Qiao , Wang Jun
Published: January 2024

In this paper, we study the existence result for a class of fractional
Schrödinger-Possion system. Using variational method and Nehari method,
we obtianed a uniqueness result for positive solutions.
Malliavin derivative of Teugels martingales and mean-field type stochastic maximum principle
Authors: Zong Gaofeng
Published: January 2024

We study the mean-field type stochastic control problem where the
dynamics is governed by a general L\’{e}vy process with
moments of all orders. For this, we introduce the power jump processes
and the related Teugels martingales and give the Malliavin derivative
with respect to Teugels martingales. We derive necessary and sufficient
conditions for optimality of our control problem in the form of a
mean-field stochastic maximum principle.
Comparative on the clinical outcomes of different connection modes of extracorporeal membrane oxygenation combine with continuous renal replacement therapy
Authors: Liu Miaomiao , Yan Yang , Li Gang , Zhang Ying , Guo Fengwei
Published: January 2024

Objective: To evaluate the effect of different connection modes of ECMO
and CRRT on patients with acute kidney injury (AKI). Methods: Twenty-one
patients received ECMO with AKI who were admitted to our center from
December 2018 to February 2021 were selected and were all treated with
both ECMO and CRRT. They were divided into A connection mode
(pre-membrane–pre-pump connection) and B connection mode
(post-membrane–post-pump connection). We compared clinical indicators
and outcomes between two connection modes. Results: There were 8 cases
(38.91%) in A connection mode and 13 cases (61.09%) in B connection
mode, with median durations of ECMO assistance of 5 days and 7 days,
respectively; median flow rates of ECMO of 3.0 L/min and 2.5 L/min,
respectively; and CRRT flow rates of 200 mL/min and 180 mL/min,
respectively. CRRT filter lifetime was over 48h in both two connection
modes. Except for NT-pro BNP, no significant differences in clinical
indicators were observed between the two groups before or after the
treatment (P > 0.05). Conclusion: Both two connection modes
could achieve the therapeutical purpose and need not higher level of
anticoagulation who are simultaneously treated with ECMO and CRRT. Two
modes had no impact on treatment effect and clinical indicators in
patients. It had no effect on length of ICU stay and prognostic.
Transcriptomic and Proteomic Insights into the Molecular Mechanism Underlying Cell Wall Biosynthesis in Moso bamboo (Phyllostachys edulis)
Authors: Geng Xin , Wang Xiaojing , Kang Lan , Chen Yuzhen , Cheng Zhanchao , Lu Cunfu , Gao Jian
Published: January 2024

As an excellent source of abundant and renewable industrial and
agricultural raw materials, the Moso bamboo stem has excellent
mechanical properties, which are closely related to the cell wall
composition and structure. However, the molecular regulation of cell
wall biosynthesis (CWB) in Moso bamboo remains unclear. We used Moso
bamboo protoplasts to investigate CWB. Transcriptome and proteome of
embryogenic calli and protoplasts at four time-points (0, 24, 72, and
120 h) were comprehensively analyzed to clarify the transcriptional and
translational changes mediating CWB. In total, 41,014 unigenes and 7,454
proteins were identified. There were significant differences between the
differentially expressed genes and differentially abundant proteins
regarding the enriched GO terms and KEGG pathways, reflecting the
temporal and spatial specificities of the samples at the transcript and
protein levels. Transcriptomic and proteomic analyses indicated that
protoplast cell wall regeneration requires the regulation of gene
expression, the guidance of the cytoskeleton system, and sufficient base
materials. Furthermore, the new cell wall is more acetylated than
methylated, and it may contain a small amount of lignin. Overall, we
provide new insights into Moso bamboo protoplast cell wall
reconstruction that may be relevant for further characterizing the
molecular mechanism controlling CWB in monocotyledons.