bluuebunny/crossref_metadata_2025 huggingface dataset:
Aquisição de produtos da agricultura familiar para o PNAE em três regiões do Paraná
Authors: Mattia Vinícius , Zonin Wilson João , Gregolin Marcos Roberto Pires
Published: March 2024

As alterações ocorridas no Programa Nacional de Alimentação Escolar (PNAE) ao decorrer do tempo, inseriram a política pública no escopo do desenvolvimento rural sustentável, tornando importante a avaliação de sua efetividade sob tal ótica de estudo. O objetivo desta pesquisa foi analisar quantitativamente a aplicação de recursos do PNAE na aquisição de alimentos da agricultura familiar nos 28 municípios das Regiões Geográficas Imediatas (RGI) de Foz do Iguaçu, Toledo e Marechal Cândido Rondon, no Paraná entre 2016 e 2019. Os dados secundários foram coletados de planilhas do Fundo Nacional de Desenvolvimento da Educação (FNDE), ajustados quando necessário, deflacionados e processados em estatística analítica e espacial. Foi possível verificar que todos os municípios adquiriam e superaram o percentual mínimo exigido por Lei de compras da agricultura familiar para o PNAE, com exceção de dois municípios em 2016. Além disso, casos específicos de melhores e piores desempenhos na aplicação dos recursos para a agricultura familiar puderam ser evidenciados.
Palavras-chave: Desenvolvimento sustentável. Políticas públicas. Segurança alimentar e nutricional. Merenda escolar. Mercados institucionais.
Research on the Theoretical Connotation and Practical Path of Aesthetics of Daily Human Life in the Background of Internet
Authors: Du Jingjing , Mahdzir Hasnul Azwan Bin Azizan , Rusman Mohd Shahril Bin , Salim Neesa Ameera Binti Mohamed
Published: March 2024

As the living standard of the people in China has changed drastically, the aesthetic quality of daily life has been increasing day by day, and people’s desire for a better life is also increasing. This paper proposes a color harmony model based on hue statistical features, using maximum likelihood estimation to extract the main hue region and extract related features from the corresponding region. Based on the inconsistencies in feature dimensions, a model is created to evaluate color harmony using Gaussian mixture training and is employed for image aesthetics evaluation. Finally, regression is employed to analyze the factors that influence life aesthetics evaluation, and the model is tested and analyzed using linear diagnosis and residual analysis. The results show that the influence index affecting the evaluation of daily life aesthetics is judgment beauty, and its influence coefficient is 4.4323. The product of image entropy and image gradient is used as the connotation of judging the aesthetics of daily human life, which is consistent with the evaluation of human aesthetic judgment. The theoretical connotations of life aesthetics are clarified and enhanced in this paper, and it develops its thinking to construct the reality of the good life.
Synergistic Effect of Silk Fibroin/Chlorogenic Acid/Citric Acid on Anti-ultraviolet and Antibacterial Properties of Cotton Fabric
Authors: Xiao Minghui , Zhang Wei
Published: March 2024

In order to obtain a durable anti-ultraviolet and antibacterial cotton fabric, silk fibroin, honeysuckle extract (chlorogenic acid) and citric acid were used to prepare a compound environment-friendly finishing agent, and then the cotton fabric was modified in this paper. Micro-morphology and properties were compared between cotton fabrics finished with a composite solution of silk fibroin/chlorogenic acid/citric acid and those finished first with silk fibroin then chlorogenic acid. Results showed that amidation and esterification crosslinking reactions occurred between the compounds and cotton fibers. Cotton fabric treated with the composite solution had higher UPF value (>90 after 30 launderings) and antibacterial rates (>95% for Staphylococcus aureus and Escherichia coli). There existed strong covalent bonds and good synergistic effects among silk fibroin, citric acid and chlorogenic acid, which could endow the cotton fabric with more durable anti-ultraviolet and antibacterial properties.
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight
Authors: Samson Fiona , Bhat Aadya , Sayyah Zachary , Reinsch Sigrid , Blaber Elizabeth
Published: March 2024

Accelerated aging in space is detrimental to long-term space missions. The environmental conditions in space (e.g., microgravity and radiation) cause harmful effects similar to those seen during aging. As the mechanistic pathways underlying accelerated aging in spaceflight are not fully understood, the identification of critical targets for promoting longevity in spaceflight remains challenging. We analyzed genomics data from the GLDS-207 project to identify potential targets related to longevity. Analysis of RNA-seq data from four Drosophila variants using the GeneLab Galaxy platform indicated that spaceflight significantly affected differential gene expression in the heads of flies, specifically in the seizure (sei) mutant, which alters the voltage gated potassium channels in the cell membrane. Spaceflight induced a significant decrease in the expression of the retinal degeneration A gene (rdgA) in mutant flies that survived the 30-day space mission. This gene encodes for the protein diacylglycerol kinase (DGK), which modulates the activation of the mechanistic target of the rapamycin (mTOR) signaling pathway, known to negatively regulate aging. Therefore, DGK may be a potential target for promoting longevity in space conditions. Further investigation of the effects of decreased rdgA expression on the lifespan of other organisms under spaceflight conditions will clarify the role of DGK in promoting longevity.
Redetection and description of the European dagger nematode Xiphinema diversicaudatum on peach (Prunus persica L.) in Canada
Authors: Akanwari Jerry , Yu Qing , Sultana Tahera
Published: March 2024

The study reports the detection of Xiphinema diversicaudatum in a peach field in Ontario, Canada. Comprehensive population characterization involved morphological and molecular analyses using 18S and 28S rDNA sequences. Morphological and molecular analysis demonstrated a close relationship between the Ontario population and those from Central Europe. This is the first report of X. diversicaudatum from peaches (Prunus persica) in Canada and in North America.
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis
Authors: Li Zhi , Wu Boquan , Chen Jie , Ye Ning , Ma Rui , Song Chunyu , Sun Yingxian , Zhang Xingang , Sun Guozhe
Published: March 2024

Background and Objectives

Cardiac injury plays a critical role in contributing to the mortality associated with sepsis, a condition marked by various forms of programmed cell deaths. Previous studies hinted at the WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) involving in heart failure and endothelial injury. However, the precise implications of WWP2 in sepsis-induced cardiac injury, along with the underlying mechanisms, remain enigmatic.

Methods

Sepsis induced cardiac injury were constructed by intraperitoneal injection of lipopolysaccharide. To discover the function of WWP2 during this process, we designed and performed loss/gain-of-function studies with cardiac-specific vectors and WWP2 knockout mice. Combination experiments were performed to investigate the relationship between WWP2 and downstream signaling in septic myocardium injury.

Results

The protein level of WWP2 was downregulated in cardiomyocytes during sepsis. Cardiac-specific overexpression of WWP2 protected heart from sepsis induced mitochondrial oxidative stress, programmed cell death and cardiac injury, while knockdown or knockout of WWP2 exacerbated this process. The protective potency of WWP2 was predominantly linked to its ability to suppress cardiomyocyte ferroptosis rather than apoptosis. Mechanistically, our study revealed a direct interaction between WWP2 and acyl-CoA synthetase long-chain family member 4 (FACL4), through which WWP2 facilitated the ubiquitin-dependent degradation of FACL4. Notably, we observed a notable reduction in ferroptosis and cardiac injury within WWP2 knockout mice after FACL4 knockdown during sepsis.

Conclusions

WWP2 assumes a critical role in safeguarding the heart against injury induced by sepsis via regulating FACL4 to inhibit LPS-induced cardiomyocytes ferroptosis.
Seasonal variations of arrhythmias and their impact on mortality in cancer patients with health disparities: A propensity score adjusted machine learning analysis of over 100 million hospitalizations across 3 years
Authors: Park Jong Kun , Monlezun Dominique , Kim Jin Wan , Going James , Khalaf Shaden , Honan Kevin , Ali Abdelrahman , Liu Victor , Barout Ahmad , Boone David , Safavi-Naeini Payam , Koutroumpakis Efstratios , Cilingiroglu Mehmet , Marmagkiolis Konstantinos , Iliescu Cezar , Karimzad Kaveh , Madjid Mohammad
Published: March 2024

Title

Seasonal Variations of Arrhythmias and Their Impact on Mortality in Cancer Patients with Health Disparities: A Propensity Score Adjusted Machine Learning Analysis of over 100 Million Hospitalizations Across 3 Years

Background

Arrhythmias are observed to increase during high influenza activity seasons (HIA, December to February) with significant clinical impact among high-risk patients, so their outcomes may be optimized through closer monitoring of these populations. It is unknown if cancer is such a risk factor.

Methods

This is a retrospective analysis of arrhythmia-related mortality and the effect of health disparities in patients with cancer during HIA and non-HIA seasons in a nationally representative database. Machine learning-augmented propensity score adjusted multivariable regression (ML-PSr) was performed using the 2016-2018 National Inpatient Sample (NIS), the United States’ largest all-payer hospitalized dataset.

Results

A number of 16,795,379 (18.48%) patients presented with arrhythmia of whom 3,214,914 (19.14%) were during HIA. In ML-PSr, HIA did not significantly increase the odds of arrhythmia for cancer patients (OR 1.01, 95%CI 0.99-1.03, p=0.37), but the odds of arrhythmia-related mortality were higher during HIA seasons (OR 1.19, 95%CI 1.12-1.27, p<0.001) compared to non-HIA seasons (OR 1.17, 95%CI 1.13-1.22, p<0.001). Primary malignancies with the highest prevalence of arrhythmias during HIA were that of the lung (19.60%), leukemia (11.49%), non-Hodgkin lymphoma (NHL) (8.24%), prostate (8.15%), and multiple myeloma (MM) (6.21%) (p<0.001). HIA increased arrhythmia-related mortality most for the following primary malignancies by year: gastrointestinal in 2016 (OR 1.15, 95%CI 1.01-1.32, p=0.039), leukemia in 2017 (OR 1.31, 95%CI 1.10-1.54, p=0.002), GI in 2018 (OR 1.14, 95%CI 1.01-1.29, p=0.029), and renal in 2018 (OR 1.54, 95%CI 1.06-2.23, p=0.025). Among patients with active cancer and arrhythmia, African Americans had significantly greater mortality than Caucasians (OR 1.13, 95%CI 1.03-1.23, p=0.013), independent of socioeconomic and clinical confounders.

Conclusion

This study suggests arrhythmia-related mortality was higher during HIA seasons compared to non-HIA seasons in cancer patients and showed notable disparities by race and worse outcomes by primary malignancy.
The Effect of Mindfulness Meditation Based on Spiritual Care with Rose Aromatherapy on Stress and Blood Pressure in Type 2 Diabetes Mellitus (DM) Patients
Authors: Hasina Siti Nur , Shodiq M. , Misutarno  , Putri Rahmadaniar Aditya , Noventi Iis , Rohmawati Riska
Published: March 2024

Background: Uncontrolled blood sugar levels in patients with type 2 diabetes mellitus can trigger various complications, one of which is macroangiopathy, which is a complication of large blood vessels that affects changes in blood pressure. Stress is considered a psychological factor that can increase blood pressure. Stressful conditions in patients with diabetes mellitus can affect the control of blood sugar levels.
 
Aim: The purpose of this study was to analyze the effect of Mindfulness Meditation based on spiritual care with rose aromatherapy on stress and blood pressure in Type 2 Diabetes Mellitus (DM) sufferers.
 
Methods: The design of this study used Quasy Experimental design with pre test and post test with control group . The population in this study were all type 2 Diabetes Mellitus sufferers. Sampling was done by purposive sampling. The total number of respondents in this study was 102, divided into 51 intervention groups and 51 control groups. The independent variables in this study were mindfulness meditation based on care and rose aromatherapy and the dependent variables in this study were stress and blood pressure. The instrument used in this study was the DASS 42 questionnaire and measuring blood pressure with a digital spygmomanometer and stethoscope. data analysis using paired t test and independent t test. The hypothesis is accepted if the p value <0.05.
 
Results: statistical test on stress levels obtained a p value of 0.000 in the intervention group and obtained a p value of 0.003 in the control group. For systolic blood pressure, a p value of 0.000 was obtained in the intervention group and and p value of 0.011 was obtained in the control group. For diastolic blood pressure, a p value of 0.000 was obtained in the intervention group and a p value of 0.042 was obtained in the control group.
 
Conclusion: Mindfulness Meditation therapy based on Spiritual Care with Rose Aromatherapy can reduce stress and systolic and diastolic blood pressure. So this research is highly recommended for nurses in carrying out independent assignments, especially in providing nonpharmacological therapy.
Políticas públicas de avaliação da educação da educação básica: desenvolvimento educacional no contexto nacional e no estado de Minas Gerais
Authors: Garcia Karla Santos , Castilho Pedro Teixeira
Published: March 2024

O presente artigo é resultado de uma revisão bibliográfica acerca dos sistemas de avaliação da qualidade da educação no Brasil e em Minas Gerais. O processo avaliativo em larga escala, tanto em âmbito federal quanto estadual, com destaque para o Estado de Minas Gerais, foi descrito através de uma linha histórica, evidenciando as transformações ocorridas nas políticas públicas, sendo as mesmas baseadas nas experiências e nos indicadores internacionais de qualidade educacional. A formalização das avaliações externas ocorreu por meio da implantação de instrumentos definidos por programas de avaliação, sendo, no contexto nacional, o Sistema Nacional de Avaliação da Educação Básica – SAEB, que abrange a Avaliação Nacional da Educação Básica – ANEB e a Avaliação Nacional do Rendimento Escolar – ANRESC (Prova Brasil) e recentemente, a Avaliação Nacional da Alfabetização – ANA. No contexto estadual, o Sistema Mineiro de Avaliação da Escola Pública – SIMAVE é composto pelo Programa de Avaliação da Aprendizagem Escolar – PAAE, pelo Programa de Avaliação da Alfabetização – PROALFA e pelo Programa de Avaliação da Rede Pública de Educação Básica – PROEB. A perspectiva crítica desta pesquisa considera que a mera mensuração dos resultados incentiva um processo de competição, que não viabiliza o melhoramento dos índices de proficiência e desenvolvimento educacional. Desse modo, pretende-se contribuir para o debate acerca das políticas de gestão pública, da avaliação da educação básica, das condições de realização das avaliações e da análise dos resultados que contribuem para melhoramento da qualidade da Educação no Brasil e em Minas Gerais.
O Open Access e a comunicação científica: as vantagens para pesquisadores e instituições e o papel do bibliotecário
Authors: Neto Udiano Campagner , Lasmar Sandra Mara
Published: March 2024

A disseminação das informações científicas através do Movimento Open Access e as novas demandas surgidas para o profissional bibliotecário, diante desta nova realidade, mostra as facetas que culminaram com o surgimento deste movimento, como o nascimento do direito autoral e seu desenvolvimento até os dias atuais; as pesquisas que resultaram com a criação da internet e a revolução ocasionada pela sua popularização; o aparecimento do Open Access Iniciative, seus princípios e diretrizes; o posicionamento do Brasil nesse trabalho de disponibilização ágil das informações, novas oportunidades e o novo perfil do bibliotecário neste cenário. Busca condensar os diversos conhecimentos de cada área que resultaram no aparecimento do Movimento Open Access. Abrange o Direito Autoral, da forma como é regulamentado nos dias de hoje, como fator de atraso e limitação na divulgação dos resultados de pesquisas; os verdadeiros motivos por trás do desenvolvimento da internet antes de sua popularização e como estes dois fatores contribuíram para que o Open Access surgisse e tivesse a aprovação de cientistas e institutos de pesquisa de todo o globo; explana um pouco das tecnologias envolvidas neste processo, sem aprofundar-se, contudo, neste conhecimento. O Brasil, através do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), é um dos países que mais investe neste movimento, apesar de todas as dificuldades políticas, sendo líder deste movimento na América Latina e firmando convênios de cooperação internacional com Portugal e Espanha.
Influência da lateralidade no desenvolvimento motor de crianças de cinco anos
Authors: Trigo Ricardo Wagner de Mendonça , Mourão Elaine Aparecida Ferreira
Published: March 2024

O presente trabalho aborda, através de pesquisa bibliográfica, questões a respeito da lateralidade, desenvolvimento motor e relações com a psicomotricidade em crianças com cinco anos de idade. Faz uma abordagem a respeito do papel do professor de educação física, fundamentado nos Parâmetros Curriculares Nacionais, e seu trabalho com objetivos voltados para a solução de problemas de má lateralidade apresentados por crianças na faixa etária em estudo. Considera as dificuldades acarretadas pela má definição da lateralidade, pois esta é um fator de fundamental importância para o desenvolvimento das crianças. Aborda ainda, como a Educação Física escolar pode auxiliar no processo ensino-aprendizagem e fazer com que a criança supere as dificuldades apresentadas, dando enfoque especial à utilização do próprio corpo como ferramenta pedagógica.
Considerações acerca das políticas públicas na área da educação inclusiva para surdos
Authors: Garcia Karla Santos
Published: March 2024

A inclusão é por si só uma temática complexa e repleta de aspectos polêmicos que trazem à tona limitações e problemas. Neste contexto, este artigo científico propõe-se apresentar as políticas públicas relevantes que contemplam o ensino inclusivo. Utilizou-se como estratégia metodológica a pesquisa bibliográfica, realizada a partir da análise crítico-reflexiva de documentos legais, obras publicadas sobre o assunto, artigos digitalizados em meio eletrônico e outros materiais afins. Assim, as ideias e opiniões de autores como Aranha, Blattes, Brasil, Bruno, Damázio, Duk, Lima, Sassaki, dentre outros, sustentaram teoricamente este estudo e permitiram-nos refletir sobre o ensino inclusivo, bem como identificar as políticas públicas direcionadas a esta modalidade educativa. Conclui-se que ao longo da história da educação, as políticas públicas direcionadas à perspectiva inclusiva, passaram por avanços e retrocessos, no entanto, têm alcançado progressos gradativos, no sentido de reconhecer todas as pessoas como seres singulares, garantindo, assim, atendimento educacional especializado, aqueles que necessitam.
Qualidade da prestação de serviços públicos: uma análise sobre a ótica da Teoria da Burocracia
Authors: Gomes Sérgio Ricardo
Published: March 2024

O presente trabalho tem como objetivo principal fazer uma abordagem sobre a Teoria da Burocracia e a qualidade da prestação de serviços nas organizações públicas e ou privadas. Faz uma reflexão, procurando ressaltar as diferenças entre morosidade e burocracia, fato que cotidianamente é subentendido pela sociedade em geral, causando uma confusão de interpretação. A metodologia utilizada nesta abordagem foi a exploratória, descritiva e empírica, bem como a observação participante, onde por meio destas técnicas possibilitou-se concluir quais fatores são mais relevantes e que geram a confusão que há de compreender corretamente as diferenças existentes entre burocracia e morosidade. Nesse sentido, o trabalho demonstra que, muitas vezes, a dificuldade encontrada pelo cidadão em solucionar alguma demanda, tem sido relacionada com a burocracia no processo, no entanto, identifica outros motivos, entre eles a necessidade de melhor capacitação do servidor prestador de serviços, bem como, a necessidade igualmente, da implantação de políticas de reconhecimento do potencial humano (intelectual e pessoal) destes servidores, demonstrando a eles sua condição real de plena prestação de serviços satisfatórios e eficazes aos cidadãos que os procuram buscando atendimento.
NUMERICAL STUDY OF MECHANICAL BEHAVIOR OF REPAIRED INCLINED CRACKED UNDER COMPLEX SHEAR-SHEAR LOAD: PERFORMANCE AND DURABILITY OF ALUMINUM 2024-T3 PLATE
Authors: Allem Ahmed , Salem Mokadem , Talbi Sofiane , Sahli Abderahmane
Published: March 2024

In this study, a finite element model was developed to analyze the mechanical behavior of repairing aluminum 2024-T3 structures subjected to complex shear-shear loads using composite patch repair techniques. The study aimed to investigate the effect of different patch sequences on the mechanical behavior of the repaired structure, including the orientation of the fiber patch, to improve durability under complex shear-shear loading conditions. The study demonstrated that the FEM approach is a robust and precise method for optimizing patch repair and studying the effect of mechanical loads on patch repair effectiveness for aluminum 2024-T3 structures.
Desigualdad de género y violencias en la práctica docente de la Facultad de Arquitectura (UNAM). Experiencias de profesoras universitarias
Authors: Suri Salvatierra Karime
Published: March 2024

Este artículo consigna algunos hallazgos que se identificaron en la primera fase de una investigación cualitativa, en la que se entrevistó a mujeres que se desempeñan como docentes de las licenciaturas en arquitectura y urbanismo de la Facultad de Arquitectura de la Universidad Nacional Autónoma de México (FA-UNAM). La investigación tiene el objetivo de identificar prácticas en la enseñanza de las disciplinas arquitectónico-urbanísticas que podrían fortalecer estereotipos de género e invisibilizar violencias en contra de las mujeres —profesoras y/o alumnas—. A través de la “entrevista feminista”, se busca conocer la especificidad de las experiencias de las mujeres como docentes en un espacio académico y disciplinar que aún exhibe una enérgica estructura patriarcal.
1923: Dos vías ateneístas de entender al intelectual (La falange y Vida mexicana)
Authors: Vuelvas Solórzano Marco Antonio
Published: March 2024

La tarea inmediata de los gobiernos mexicanos post revolucionarios en la década de los veinte fue la creación y consolidación de instituciones que construyeran el programa ideológico del nuevo Estado. En esa tarea, los intelectuales tuvieron un papel destacado, particularmente en el debate sobre las definiciones de la cultura e identidad nacional, en que se propició un ambiente de intercambio de ideas, así como de tensiones entre diferentes grupos artísticos e intelectuales. Este artículo analiza dos grupos en específico: el primero, encabezado por José Vasconcelos y el segundo, por Pedro Henríquez Ureña. Ambos personajes compartieron un vínculo intelectual y propósitos comunes, pero con maneras diferenciadas de cumplir con esas metas: el primero, como un hacedor de instituciones, vinculado directamente con la estructura gubernamental y las acciones de gobierno y, el segundo, como crítico social, además de atender el perfeccionamiento de su actividad artística. Así, a través del análisis comparativo de dos publicaciones en particular: La falange. Revista de cultura latina, como órgano del grupo vinculado con José Vasconcelos, y Vida Mexicana. Revista mensual de ideas de interés, por parte quienes siguieron a Pedro Henríquez Ureña, se analiza la trayectoria de dos formas de entender el papel social que se atribuía a los intelectuales, los puntos en común de estos grupos, así como las diferencias en los proyectos y trayectorias que siguieron después.
DETECTION OF SOME BACTERIAL CAUSES OF WATERY DIARRHEA IN THE PROVINCE OF BAGHDAD AND SOME NORTHERN GOVERNORATES WITH ASTUDY OF PATHOLOGICAL EFFECTS
Authors: Kadhim Suadad , Saleh Dhuha
Published: March 2024

The present study Investigate the study on the causes of diarrhea epidemic in the province of Baghdad and some northern governorates since been collected 140 stool samples of water of different ages for the period from the beginning of the month of October 2007 to the end of August 2008, after culture ,microscopic biochemical testing diagnosed (113) bacterial isolates was among them ( 66) isolation rate of (% 47.14) only belonging to Vibrios cholera, Vibrio cholerae are divided by (58) in a rate (% 87.87) and returned to the pattern under serum Inaba, and (5) isolates, a rate (% 7.57) and returned to the pattern under serum Ogawa, all belonging to the pattern of bio-El-Tor and three isolates by (4.54%) belonging to non-cholera vibrios NAG The study showed the presence of 10 bacterial isolates were similar in most characteristics of the cholera bacteria, vibrios with some of the differences that emerged when Biochemical tests, which gave a negative result of the examination and testing of cholera red stitching and nitrate reduction Histopathological study using experimental animals indicate similarity in pathogenesis of V. cholerae and vibrio like bacteria ,both cause congested spleen and liver and desquamation in the intestinal villi
AVANÇOS NO ENTENDIMENTO DA PATOGENIA DA COVID-19: UMA REVISÃO
Authors: Berber Gilcele Campos Martin , Slhessarenko Renata Dezengrini
Published: March 2024

Introdução: O SARS-CoV-2, causador da pandemia por Doença por Coronavirus 2019 (COVID-19) gerou desafios à saúde pública, principalmente pelo conhecimento escasso de sua patogênese, e de estratégias terapêuticas e preventivas eficazes. Diversas lacunas de conhecimento sobre a doença envolvem a contribuição de fatores de risco, as doenças concomitantes, os fatores genéticos e imunogenéticos, no direcionamento da resposta imune, bem como a hiperinflamação, a imunidade antiviral e os alelos dos antígenos leucocitários humanos (HLAs) dos pacientes, que estão relacionados ao desfecho da doença. Objetivo: Esta revisão integrativa objetivou aprofundar os conhecimentos sobre os mecanismos de imunidade relacionada aos fatores de risco, da hiperinflamação e da tempestade de citocinas decorrente da infecção por SARS-CoV-2, bem como os avanços de associação dos HLAs nos agravos da doença. Metodologia: A revisão integrativa foi realizada utilizando os descritores nas bases de dados PubMed, SCIELO, CINAHL, SCOPUS, Web of Science, MedNar, Portal periódicos CAPES e Open Journal System, sem limites de janela cronológica. Resultados: Os efeitos da pandemia e os esforços na busca do conhecimento sobre a patogênese da COVID-19 resultaram em avanço no combate da doença. Conseguiu-se relacionar fatores de risco como obesidade, hipertensão, diabetes, doenças renais crônicas, idade, gênero, e outras condições predisponentes ao agravo da doença. Sob o aspecto da patogênese, também houveram progressos no entendimento dos mecanismos celulares e humorais em resposta à doença, bem como conseguiu vincular a resposta da hiperinflamação e o perfil dos HLAs dos pacientes à evolução da doença ao óbito ou à convalescência. Conclusão: Os esforços científicos conjuntos e os avanços na compreensão dos mecanismos da doença conseguiram estabelecer estratégias de combate a COVID-19, resultando no fim da pandemia, porém ainda há avanços que devem ser alcançados para o combate das sequelas dos pacientes convalescentes e para minimização da COVID longa e seus prejuízos.
PREVALÊNCIA E FATORES ASSOCIADOS À DOENÇA RENAL CRÔNICA EM PACIENTES HIPERTENSOS CADASTRADOS NA ESTRATÉGIA DE SAÚDE DA FAMÍLIA DE RIO BRANCO, ACRE
Authors: Oliveira Pontes Ualison , Torres Rego Monteiro Gina , De Araújo Amaral Cledir , Teixeira Leite de Vasconcellos Maurício , Lameira Maciel Amaral Thatiana
Published: March 2024

Introdução: analisar a prevalência e os fatores associados à doença renal crônica em pessoas com hipertensão arterial (HAS) cadastrados na Estratégia de Saúde da Família em Rio Branco, Acre. Método: Trata-se de um estudo transversal realizado com hipertensos cadastrados nas Estratégias de Saúde da Família (ESF), na zona urbana de Rio Branco, Acre, em 2019. A DRC foi definida por TFG < 60 ml/1,72m², estimada a partir da fórmula Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), ou presença de albuminúria > 29 mg/g. Medidas de associação foram estimadas por regressão logística, com grau de confiança de 95%. Resultados: A prevalência de DRC foi de 27,3% em pessoas com HAS. Observou-se associação estatisticamente significativa nos pacientes hipertensos entre DRC e escolaridade (ensino fundamental – OR: 1,56; IC95%:1,09; 2,23; sem escolaridade – OR:1,87; IC95%: 1,14; 3,07), não controle da pressão arterial (OR: 2,39; IC95%: 1,45; 3,94), sedentarismo (OR: 1,63; IC95%: 1,02; 2,60). Conclusão: A DRC apresenta alta prevalência nos hipertensos, evidenciando a necessidade de medidas em saúde pública para prevenção de complicações mediante melhor controle da doença e mudanças no estilo de vida.
Cilvēka dabiskais stāvoklis Hobsa, Loka un Ruso skatījumā
Authors:   Rīgas Stradiņa universitātes Humanitāro zinātņu katedra, Graudiņa Elīna
Published: March 2024

Elīna Graudiņa in her article “The Natural State of Human According to Hobbes, Locke and Rousseau” examines the views and visions of Enlightenment thinkers on the position of an individual and society in relation to the State, society and each other. Hobbes describes the natural human condition as a selfish desire for self-preservation, characterised by a spirit of competition, distrust and fear. It is the development of “natural law” according to which a man is free to do whatever they like, and “the state of war of all against all” begins. In his natural state, man has both external freedom of action and internal freedom of will, and therefore a natural right to everything. A state where duties and rights are based on contract is a system in which the individual’s selfishness is overridden by his duty to himself, to his neighbour and to the state at large. John Locke argues that there is no innate knowledge in the individual and that man is born as a “blank slate”. He believed that an individual’s personality, knowledge and character are formed as a result of the influences of the world around him. All human beings are free, equal and independent by nature. Thomas Hobbes’s social contract theory was further developed and simultaneously criticized by Jean Jacque Rousseau. He describes transition from the state of nature to the state of citizenship. This transition brings about a remarkable change in man, replacing instinct with justice in their behaviour, giving their actions a moral meaning. What man loses with the social contract is their natural freedom, limited only by the forces of an individual. It must be distinguished from civil liberty, which is limited by the general will and property. Rousseau defends the thesis that man is good by nature and only society corrupts them morally. The philosopher cites a faulty education as one of the reasons for this, and therefore calls for an immediate reform of pedagogy, replacing traditional methods of education with “natural education”. The reform in question is based on precise knowledge of the nature of the child. Several centuries have passed since Hobbes’s conclusions on the selfishness of human nature, but this does not change the fact that the “natural state” of man has not really changed, emphasises Elīna Graudiņa. / Elīna Graudiņa rakstā “Cilvēka dabiskais stāvoklis T. Hobsa, Dž. Loka un Ž. Ž. Ruso skatījumā” aplūko apgaismības laika domātāju redzējumu un uzskatus par indivīda un sabiedrības stāvokli attiecībā pret valsti, sabiedrību, citam pret citu. Atslēgvārdi: Cilvēka dabiskais stāvoklis; valsts; sabiedrība; T. Hobss; Dž. Loks; Ž. Ž. Ruso; apgaismība; vara.
Expanding the spectrum on brain-heart interactions in cerebellopontine angle surgeries
Authors: Sharma Prachi , Krishnaswami Sharath , Shah Keyur , Surve Rohini M.
Published: March 2024

Lesions at the cerebellopontine angle (CP angle) are associated with various brain-heart interactions, which can include those from stimulation of the fifth cranial nerve along the scalp incision in a retrosigmoid suboccipital surgical approach. A 27-year-old male patient with recently diagnosed hypertension (on calcium channel blocker) underwent left CP angle lesion decompression. Transient episodes of bradycardia, hypotension, and bradypnea were observed from the skin incision onward, exacerbated during tumor manipulation. Most episodes subsided with cessation of the surgical stimulus while some required intervention. Postoperatively, blood pressure decreased below the pre-operative levels. Thus, trigeminocardiac reflex can occur as early as the skin incision even in a retrosigmoid approach due to stimulation of the mandibular division, when specific risk factors exist. Such episodes may serve as early warning signs for subsequent intraoperative occurrences. Brainstem compression can be a possible etiology of hypertension in young patients. It underscores the importance of considering brain-heart interactions in surgical interventions involving the CP angle.
Sphenopalatine ganglion block for the treatment of spontaneous intracranial hypotension without demonstrable cerebrospinal fluid leak: A report of two cases
Authors: Khandelwal Ankur , Sarma Sanghamitra , Hussain Masaraf
Published: March 2024

Spontaneous intracranial hypotension (SIH) is a condition characterized by orthostatic headache associated with nausea, vomiting, tinnitus, vertigo, hypoacusis, neck pain/stiffness, and photophobia. Usual treatment includes bed rest, hydration, caffeine, analgesics, epidural blood patch, steroids, fibrin glue (N-butyl-cyanoacrylate), and surgical repair. In this series, we report two cases, who presented to us with features of SIH and were managed successfully with sphenopalatine ganglion block. This is a novel modality of management of SIH and has not been reported before.
Farmer’s mental health and well-being: Qualitative findings on protective factors
Authors: Saju Sayujya , Reddy Shanivaram K. , Bijjal Somashekhar , Annapally Sadananda Reddy
Published: March 2024

Objectives:

Agriculture is associated with various physical and mental health risks. There has been growing concern about the psychological hazards associated with farming including high stress levels, depression, anxiety, and increasing rates of suicide. To bolster resilience and overall survival within the farmers, it is imperative to gain a comprehensive understanding of the protective factors that contribute to mental and psychological well-being.

Materials and Methods:

The study followed an explorative research design and used purposive sampling to select samples from Chikkaballapur District in Karnataka. Nine farmers were interviewed based on inclusion and exclusion criteria. The interview schedule was prepared based on the literature review. Experts in the field did content and face validation. The transcribed data were coded using the free version of QDA Miner. The thematic analysis approach was used for data analysis,

Results:

Three broader themes and 15 sub-themes emerged: (1) Personal protective factors: feeling of autonomy, purpose in life, passion for work, problem-solving skills, positive mindset and building resilience, learning new skills, and spiritual and religious beliefs; (2) social protective factors: friends and peer group, belongingness, family, and social engagements; and (3) environmental protective factors: lifestyle and being physically active, rural environment, government/institutional support, and recognition in the society.

Conclusion:

The study successfully emerged three overarching protective factors that farmers perceived as significant for their mental health and well-being, entitled personal, social, and environmental. The study findings provide valuable insights for social work practitioners, guiding them in developing interventions and strategies to support the mental health and well-being of the farming population.
Prayer among Mixed Communities of Secular and Religious Jews: The Integrated Education Test Case
Authors: Fuchs-Abarbanel Carmit , Cohen Asher
Published: March 2024

A prevalent research assumption is that the religious-secular divide is one of the most divisive topics in Jewish society in Israel. Accumulated data in this field has led to a search for social solutions rather than purely political ones. Newly created mixed religious-secular communities attest to attempts to establish a new social order, at least among those taking part in this process. The present paper focuses on prayer as one of the most prominent identity issues in many of these communities. The underlying assumption is that the mixed community phenomenon is unique and exceptional and, in many ways, runs counter to the dominant trend in Israeli society in the context of the religious-secular divide, normally characterized by separate communities and education systems. The paper examines the challenge of prayer in integrated education systems by presenting the dilemmas encountered by these communities, their internal methods of decision-making, and diverse mechanisms for coping with the issue of participation in prayer in schools. The data was obtained from a qualitative study that included semi-structured interviews and content analysis of documents and publications pertaining to these communities. The research questions focus on the methods, style, and frequency of prayer. The study also examines whether prayer undermines the value of unity or rather facilitates individual uniqueness within the joint activities. Finally, the study examines the most prominent educational approach to coping with the question of prayer in schools, which has led to diverse educational solutions such as the establishment of several alternatives for morning discourse at school.
Analysis of Integrated Coastal Management (ICM) of El Salvador
Authors: Martínez Morales Leydi Diana , Mendoza Franco Edgar F.
Published: March 2024

The Republic of El Salvador has a small marine coastal zone that is deteriorated by uncontrolled anthropogenic activities; the implementation of an integrated coastal management program (ICM) is necessary to mitigate the damage caused to marine zones and the performance of coastal governance to provide sustainable development. The purpose of this study is collect information on policies, laws and instruments that focus on the conservation and development of the coastal marine areas of El Salvador.
Keywords: Integrated Coastal Management (icm), coastal policies, coastal conservation, development of the coastal zone, El Salvador.
Polymorph-Specific Solubility Prediction using Constant Chemical Potential Molecular Dynamics
Authors: Neha  , Aggarwal Manya , Soni Aashutosh , Karmakar Tarak
Published: March 2024

Molecular Dynamics (MD) simulations offer a robust approach to understanding material properties within a system. Solubility is defined as the analytical composition of a saturated solution expressed as a proportion of designated solute in a designated solvent, according to IUPAC. It is a critical property of compounds and holds significance across numerous fields. Various computational techniques have been explored for determining solubility, including methods based on chemical potential determination, enhanced sampling simulation, and direct coexistence simulation, and lately, machine learning-based methods have shown promise. In this investigation, we aim to find the solubility values of a compound through Constant Chemical Potential Molecular Dynamics, a method rooted in direct coexistence simulation. The primary purpose of using this method is to overcome the limitation of the direct simulation method by maintaining a constant chemical potential for a sufficiently long time. Urea is chosen as a prototypical system for our study, with a particular focus on three of its polymorphs. Our approach effectively discriminates between the polymorphs of urea based on their respective solubility values; polymorph III is found to have the highest solubility followed by form IV and I.
Structural, Ionic, and Electronic Properties of Solid-State Phthalimide-Containing Polymers for All-Organic Batteries
Authors: Alessandri Riccardo , Li Cheng-Han , Keating Sheila , Mohanty Khirabdhi T. , Peng Aaron , Lutkenhaus Jodie L. , Rowan Stuart J. , Tabor Daniel P. , de Pablo Juan J.
Published: March 2024

Redox-active polymers serving as the active materials in solid-state electrodes offer a promising path towards realizing all-organic batteries. While both cathodic and an- odic redox-active polymers are needed, the diversity of the available anodic materials is limited. Here, we predict solid-state structural, ionic, and electronic properties of anodic, phthalimide-containing polymers using a multiscale approach that combines atomistic molecular dynamics, electronic structure calculations, and machine learning surrogate models. Importantly, by combining information from each of these scales, we are able to bridge the gap between bottom-up molecular characteristics and macro- scopic properties such as apparent diffusion coefficients of electron transport ($D_{app}$). We investigate the impact of different polymer backbones and of two critical factors during battery operation: state of charge and polymer swelling. Our findings reveal that the state of charge significantly influences solid-state packing and the thermophys- ical properties of the polymers, which, in turn, affect ionic and electronic transport. A combination of molecular-level properties (such as the reorganization energy) and condensed-phase properties (such as effective electron hopping distances) determine the predicted ranking of electron transport capabilities of the polymers. We predict Dapp for the phthalimide-based polymers and for a reference nitroxide radical-based polymer, finding a three orders of magnitude increase in $D_{app}$ ($\approx 10^{−6}$ cm$^2$ s$^{−1}$) with respect to the reference. This study underscores the promise of phthalimide-containing polymers as highly capable redox-active polymers for anodic materials in all-organic batteries, due to their exceptional predicted electron transport capabilities.
MAJOR CORPORATIONS AND ENVIRONMENTAL ADVOCACY: EFFORTS IN REDUCING ENVIRONMENTAL IMPACT IN OIL EXPLORATION
Authors: Banso Adeyinka Alex , Ofonagoro Kelechi Anthony , Olurin Joy Otibhor , Ayodeji Sodrudeen Abolore , Ehiaguina Vincent Ebhohime , Ndiwe Tina Chinyere , Daraojimba Chibuike
Published: March 2024

This comprehensive study embarked on a critical journey to scrutinize and evaluate the effectiveness of corporate environmental initiatives implemented in recent years, particularly focusing on the oil sector. Utilizing a meticulous literature review strategy, the research analyzed various case studies and scholarly contributions to delineate the current state of environmental advocacy in the corporate sector and identify potential avenues for future research. The methodology encompassed a systematic data extraction and analysis approach, ensuring relevant and reliable data assimilation. The findings underscored a significant shift in the corporate sector towards fostering environmental sustainability through various initiatives spanning different industries. Environmental advocacy has emerged as a potent force urging the industry to adopt more sustainable and ethical practices, particularly in the oil sector. The study revealed a growing awareness and commitment to fostering a sustainable and environmentally responsible corporate sector, characterized by green innovation, sustainable practices, and corporate social responsibility. Based on the analysis, the study recommends developing and implementing robust regulatory frameworks to mandate adherence to sustainable practices, promoting green innovation, and fostering collaborative efforts among various stakeholders. These strategies are envisaged to propel the corporate sector as a significant player in global environmental conservation efforts. Looking ahead, the study identifies a promising trajectory for environmental advocacy, characterized by collaborative efforts, regulatory frameworks, and green innovation, setting a pathway towards a sustainable and environmentally responsible corporate sector.
EVALUATION OF CONSTRUCTION MATERIALS ON PROJECT SITES IN FEDERAL CAPITAL TERRITORY, F.C.T, ABUJA
Authors: F. Micheal, , A. Mahmoud, , K.S Ishaya, , S.Y Kpalo,
Published: March 2024

Assessment of building construction material on building sites is a function that critically contributes to the achievement of the project goals. Poor construction materials in construction projects sites has many issues which contribute to it such as: wastage of construction materials, and improper handling on site. This work aims to consider the evaluation of construction materials on project sites. Questionnaires from field survey, interview and site observation were the source of data collected. Descriptive statistics including frequency and mean index score method was used for the study. The study reveals that most problems such as conditions of weather, management of excess materials as well as low response from company to site were identified with mean value above the average mean of 3.32. The study also indicated that most wastage, such as: change in design, improper scheduling of work plan, and lack of supervision in usage of materials observed with mean value above the average mean of 3.37. From the results of the study, it was concluded that, most activities on management of construction materials which are challenging that has to do with wastage in building construction project sites and management of construction material, were identified in the study area. Thus, the study recommends that the consultants, contractors, clients and other professionals that work in the building construction industry should upgrade their commitment toward staff training as well as developing the necessary skills needed in the industry.
CONSTRUCTION SAFETY INSPECTION PLATFORM OF HIGH-SPEED RAILWAY SUPER LARGE SWIVEL BRIDGE BASED ON NUMERICAL SIMULATION
Authors: Zhanga Yongjun , Maa Qiangqiang , Mab Tianhui , Xiec Shengrong , Peng Jun
Published: March 2024

In recent years, when building bridges across existing railways, in order to reduce the interference to the railway operation line during the construction process, parallel railways are often used to cast bridges and then rotate them. In this paper, combined with the engineering example of Zhaochuan Super Swivel Bridge on Beijing-Zhanghai High-speed Railway, the key and difficult points of the swivel bridge during construction are monitored, and compared with the computer simulation data, the static friction coefficient, dynamic friction coefficient and friction couple distance of the swivel system are obtained. Model each component of the bridge body, establish a safety monitoring and early warning method, system, storage medium, and early warning platform, and visually display the safety degree of components at different stages and locations by color discrimination.