bluuebunny/crossref_metadata_2025 huggingface dataset:
Tracing Emergence of SARS-CoV-2 Variants: Insights from Comprehensive Assessment Using Reverse Transcription Polymerase Chain Reaction and Whole Genome Sequencing
Authors: Na Duyeon , Hong Yuna , Lee Chaeyeon , Kim Myungshin
Published: January 2025

The emergence and evolution of SARS-CoV-2 variants, such as Delta and Omicron, pose significant challenges to pandemic management. This study evaluated the effectiveness of reverse-transcription polymerase chain reaction (RT-PCR) and whole-genome sequencing (WGS) in detecting and characterizing SARS-CoV-2 variants using 624 samples collected in South Korea from mid-2021 to mid-2022. Two RT-PCR genotyping assays demonstrated a high concordance rate (90.4%) in identifying the Delta variant during its dominance. In contrast, WGS revealed extensive genetic diversity among Omicron sub-lineages, identifying 29 distinct sub-lineages, including two South Korea-specific variants (BA.1.1.5 and BA.2.3.8). Clustering analysis of WGS data highlighted distinct groupings of BA.1, BA.2, and BA.5 sub-lineages, with overlap in shared mutations suggesting evolutionary convergence. Sub-lineage diversity expanded during rapid transmission phases and subsequently consolidated as dominant lineages emerged. These findings highlight the complementary strengths of RT-PCR and WGS and underscore the importance of integrating these methodologies for effective variant monitoring and public health response.
Volcanic Response to Post-Pan-African Orogeny Delamination: Insights from Volcanology, Precise U-Pb Geochronology, Geochemistry, and Petrology of the Ediacaran Ouarzazate Group of the Anti-Atlas, Morocco
Authors: Mediany Mohamed Achraf , Youbi Nasrrddine , Ben Chra Mohamed , Moutbir Oussama , Hadimi Ismail , Mata João , Wotzlaw Jörn-Frederik , Madeira José , Doblas Miguel , Khalaf Ezz El Din Abdel Hakim , Oukhro Rachid , El Moume Warda , Ounar Jihane , Lahna Abdelhak Ait , Boumehdi Moulay Ahmed , Bekker Andrey
Published: January 2025

Post-collisional volcanism provides valuable insights into mantle dynamics, crustal processes, and mechanisms driving orogen uplift and collapse. This study presents geological, geochemical, and geochronological data for Ediacaran effusive and pyroclastic units from the Taghdout Volcanic Field (TVF) in the Siroua Window, Anti-Atlas Belt. Two eruptive cycles are identified based on volcanological and geochemical signatures. The first cycle comprises a diverse volcanic succession of basalts, basaltic andesites, andesites, dacites, and rhyolitic crystal-rich tuffs and ignimbrites, exhibiting arc calc-alkaline affinities. These mafic magmas were derived from a lithospheric mantle metasomatized by subduction-related fluids and are associated with the gravitational collapse of the Pan-African Orogen. The second cycle is marked by bimodal volcanism, featuring tholeiitic basalts sourced from the asthenospheric mantle and felsic intraplate magmas. These units display volcanological characteristics typical of facies models for continental basaltsuccessions and continental felsic volcanoes. Precise CA-ID-TIMS U-Pb zircon dating constrains the volcanic activity to 575–557 Ma, reflecting an 18-million-year period of lithospheric thinning, delamination, and asthenospheric upwelling. This progression marks the transition from orogen collapse to continental rifting, culminating in the breakup of the Rodinia supercontinent and the opening of the Iapetus Ocean. The TVF exemplifies the dynamic interplay between lithospheric and asthenospheric processes during post-collisional tectonic evolution.
Light-Activable Silver Nanoparticles for Combatting Antibiotic-Resistant Bacteria and Biofilms
Authors: Godakhindi Varsha , Kravitz Elana , Vivero-Escoto Juan Luis
Published: January 2025

Silver nanoparticles (AgNPs) are among the most widely used nanoparticulate materials for antimicrobial applications. The innate antibacterial properties of AgNPs are closely associated with the release of silver ions (Ag+) and the generation of reactive oxygen species (ROS). Multiple reports have elaborated on the synergistic effect against bacteria by combining photosensitizers with AgNPs (PS-AgNPs). This combination allows for the light-activated generation of Ag+ and ROS from PS-AgNPs. This is an efficient and controlled approach for the effective elimination of pathogens and associated biofilms. This review summarizes the design and synthetic strategies to produce PS-AgNPs reported in the literature. First, we explore multiple bacterial cell death mechanisms associated with AgNPs and possible pathways for resistance against AgNPs and Ag+. The next sections summarize the recent findings on the design and application of PS-AgNPs for the inactivation of resistant and non-resistant bacterial strains as well as the elimination and inhibition of biofilms. Finally, the review describes major outcomes in the field and provides a perspective on the future applications of this burgeoning area of research.
Perfectionism, Orthorexia Nervosa, and Body Composition in Young Football Players: A Cross-Sectional Study
Authors: Zydek Grzegorz , Kardas Marek , Staśkiewicz-Bartecka Wiktoria
Published: January 2025

Background: The pursuit of excellence in sports often drives athletes to maintain rigorous dietary and physical standards, sometimes leading to disordered eating patterns like orthorexia nervosa. The purpose of this study is to evaluate the relationship between perfectionism, body composition, and the risk of orthorexia among young soccer players. Methods: A cross-sectional study was conducted with 93 young football players aged 15–24 from a football academy. Perfectionism was assessed using the Perfectionism in Sport Questionnaire, while orthorexia nervosa risk was evaluated using the Düsseldorf Orthorexia Scale. Body composition parameters, including body mass index, lean body mass, skeletal muscle mass, fat mass, and fat percentage, were analyzed using multi-frequency bioelectrical impedance. Results: Higher levels of negative perfectionism were significantly associated with increased orthorexia nervosa risk (p = 0.006), while positive perfectionism showed no significant correlation. Younger players exhibited higher negative perfectionism scores compared to older groups (p = 0.043). No significant relationships were found between body mass index, body composition parameters, and orthorexia nervosa risk (p > 0.05). Conclusions: This study highlights the psychological underpinnings of orthorexia nervosa risk in young athletes, emphasizing the influence of negative perfectionism and the limited role of body composition. Early intervention focusing on reducing negative perfectionism and promoting adaptive perfectionism could support both psychological well-being and athletic performance. Future research should investigate long-term trends and the role of sociocultural factors in orthorexia nervosa development.
Investigating a Sustainable Inventory System with Controlled Non-Instantaneous Deterioration for Green Products via the Dragonfly Algorithm
Authors: Alharbi Majed
Published: January 2025

Sustainability is essential in addressing the environmental impacts of supply chains, a significant source of global emissions. This study develops an inventory model to optimize retailer profit by integrating joint pricing, environmental investment, ordering costs, preservation technology, and replenishment timing for non-instantaneously decaying items. Demand depends on stock and selling price, while an algorithm optimizes variables such as selling price, preservation investment, emission costs, ordering costs, and replenishment cycles. The dragonfly algorithm (DA) is employed to find optimal solutions, with numerical analysis demonstrating the model’s application. To justify the results, we have used an updated version of the dragonfly algorithm. Managerial insights highlight the practical relevance of the proposed framework.
Mobile Applications and Green Economy as a Factor of Transformation in the Tourism Sector: Theoretical Contexts, User Expectations, and Development Perspectives
Authors: Majdak Piotr , Saramonowicz Bartosz
Published: January 2025

In the face of escalating global challenges related to the climate crisis, depletion of natural resources, and growing social inequalities, tourism—one of the fastest-growing industries worldwide—must undergo a transformation toward more responsible travel planning and implementation. In this context, the concepts of the green economy and sustainable tourism provide valuable inspiration. Despite widespread consensus on the validity of these concepts, their implementation across various regions encounters numerous social, political, technological, and cultural challenges. Mobile applications used during tourist activities can play a pivotal role as widespread carriers of values and ideas aligned with the principles of the green economy and sustainable development. This article focuses on two key areas. The first outlines theoretical frameworks for leveraging mobile applications to shape travelers’ attitudes in accordance with the green economy and sustainable development principles. The second area refers to original research on user preferences and expectations regarding sustainable solutions in mobile applications. The findings of the research indicate that mobile applications possess a vast potential to influence tourists’ decisions and behaviors. In this context, they can serve as a critical factor in supporting the transformation of the tourism industry towards the objectives of sustainable development and the green economy.
Quasi-Sure Exponential Stability of Stochastic Differential Delay Systems Driven by G-Brownian Motion
Authors: Fei Chen , Yang Luzhen , Fei Weiyin
Published: January 2025

This paper focuses on the quasi-sure exponential stability of the stochastic differential delay equation driven by G-Brownian motion (SDDE-GBM): dξ(t)=f(t,ξ(t−κ1(t)))dt+g(t,ξ(t−κ2(t)))dZ(t), where κ1(·),κ2(·):R+→[0,τ] denote variable delays, and Z(t) denotes scalar G-Brownian motion, which has a symmetry distribution. It is shown that the SDDE-GBM is quasi-surely exponentially stable for each τ>0 bounded by τ*, where the corresponding (non-delay) stochastic differential equation driven by G-Bronwian motion (SDE-GBM), dη(t)=f(t,η(t))dt+g(t,η(t))dZ(t), is quasi-surely exponentially stable. Moreover, by solving the non-linear equation on τ, we can obtain the implicit lower bound τ*. Finally, illustrating examples are provided.
Symmetry Study on Damage Inversion of Wharf Pile Foundation in Three Gorges Reservoir Area Under Ship Impact
Authors: Zuo Liangdong , Wang Quanbao , Liu Jia , Li Jie
Published: January 2025

Periodic change in reservoir water level will have a significant impact on berthing position, and the impact caused by irregular operation during berthing will cause damage to wharf pile foundations. However, most of the existing monitoring methods adopt irregular methods, so it is difficult to accurately identify and analyze the damage causes. Taking a high-piled wharf in the Three Gorges Reservoir area as an example, the uncertainty of reservoir water level change is quantitatively analyzed. By establishing a simplified parametric wharf calculation model, the data set of an inversion model of pile of a high-piled wharf under ship impact is obtained, and the inversion analysis of pile damage of a high-piled wharf under ship pile is carried out based on the artificial neural network model. The results show that the inversion model can accurately and efficiently identify the intensity of ship impact, and a low water level is better than a high water level in the identification of impact position. In this paper, the behavior of wharf structure before and after damage is analyzed symmetrically under the action of damage inducement. In summary, the inversion analysis method can basically meet the requirements of inversion identification of pile foundation damage of a high-pile wharf in a backwater fluctuation area under ship impact.
Virtual Reality in Sports Readaptation: Future Research Directions
Authors: Rojas-Valverde Daniel , Salas-Cabrera Jorge , Gutiérrez-Vargas Randall , Gutiérrez-Vargas Juan C. , Sánchez-Ureña Braulio
Published: January 2025

This paper is concerned with the importance of virtual reality (VR) in case of readaptation in sports. It emphasizes VR’s innovative aspect of providing recovery and many other aspects associated with performance-related enhancement, injury prevention, and interdisciplinary cohesion. According to the chosen research approach, VR creates real, virtual, or simulated situations of controlled and reinforced practice where sports psychologists, health professionals, and coaches’ specialists work together. Psychosocial virtuality builds confidence, stress management, and resiliency, which may be significant factors when considering paediatric sports readaptation. It points to areas where direct attention should be given, such as security issues and the ability to play (gamification). Sports readaptation knowledge and evolution of VR with possible enhancements discussed, such as artificial intelligence integration. Within this framework, scholars utilize different sources (longitudinal studies and comparative and effectiveness research) to assess the sustained benefits of VR and analyse its strengths and limitations. The other factors which make VR widespread concern its further development into various sports disciplines, including the creation of biomechanical monitoring methods. It is promoted for the best benefit of all, including allowing everyone to use VR but not being intrusive in their activities. The manuscript highlights the innovation of VR as a paradigmatic medium for sports readaptation, with additional promises from advancements in technology, tailored care, and more high-tech solutions to achieve efficient recovery at optimum levels for athletes.
Efectos del abordaje fisioterapéutico de secuelas neuromusculoesqueléticas secundarias al síndrome post COVID-19 en personas adultas y adultas mayores
Authors: Calderón-Sequeira Andrea , Carrillo-Mora Ericka , Rivera-Vargas Juan Miguel
Published: January 2025

Introducción: establecer los efectos del abordaje fisioterapéutico de las secuelas neuromusculoesqueléticas secundarias al síndrome Post COVID-19 en personas adultas y adultas mayores.  Metodología: se realizó un estudio de revisión narrativa basada en una revisión bibliográfica sistematizada respondiendo a la pregunta cuáles son las principales secuelas neuromusculares por el COVID-19 en la población adulta y adulta mayor y cuál es su abordaje fisioterapéutico. Se utilizaron los motores de búsqueda Science Direct, Cochrane, Pubmed, SciELO, Redalyc, EBSCOhost y Google Académico. Los descriptores COVID-19, síndrome Post COVID-19, rehabilitación, terapia física, long COVID-19, adulto mayor. Se tomaron en cuenta artículos publicados del año 2020 en adelante; en los idiomas español e inglés principalmente y en alemán. Se incluyeron 47 artículos. Resultados: los síntomas más frecuentes que se encontraron son fatiga; disnea y tos. El estudio evidenció 4 abordajes principales las cuales son fortalecimiento muscular, terapia del sistema respiratorio, ejercicios aeróbicos y de propiocepción y ejercicios de equilibrio. En cada uno de estos abordajes terapéuticos se menciona la dosificación utilizada para obtener efectos positivos. Estos abordajes demuestran beneficios en la funcionalidad del paciente enfocándose en la tolerancia al ejercicio. Además; incrementa la independencia en las actividades de la vida diaria.  Conclusiones: la evidencia confirma la efectividad de la aplicación de un tratamiento fisioterapéutico sobre las secuelas persistentes del COVID-19. Se genera una adherencia al tratamiento a raíz de los efectos positivos que demuestra la aplicación de los abordajes mencionados.
Abordaje fisioterapéutico en fractura de clavícula de manejo conservador en adulto mayor: a propósito de un caso
Authors: Porras-Balladares Esteban , Bolaños-Valverde María Laura , Rivera-Vargas Juan Miguel , Centeno-Ávila María Eugenia
Published: January 2025

Las fracturas del tercio distal de la clavícula representan de un 15% a un 30 % de todas las fracturas de la clavícula, la anatomía compleja de la zona y las fuerzas externas resultan un riesgo elevado de retraso en la consolidación y la no consolidación en comparación con otras partes de la clavícula. El presente reporte de caso tiene como objetivo justificar una propuesta terapéutica realizada en una paciente de 82 años con una fractura de clavícula a nivel distal a consecuencia de una caída desde su propia altura la cual por el riesgo quirúrgico fue catalogada por los médicos tratantes como de manejo conservador. Se aplicaron tratamientos como vendajes estabilizadores, magnetoterapia, laser de alta y baja intensidad, estímulos eléctricos y ejercicio terapéutico, además de un plan de autogestión e intervenciones educativas. Se brindaron 24 sesiones de terapia física (2 a 3 veces por semana). Pese a que no se logró la consolidación ósea y como resultado la paciente se mantiene con una pseudoarticulación en la articulación acromioclavicular izquierda; por otro lado, funcionalmente se logra mitigar el dolor en su totalidad, además de rangos funcionales de movimiento completo y se completa un plan de prevención de caídas. Se concluye que el manejo conservador de las fracturas del tercio distal de la clavícula por medio de Terapia Física representa una estrategia alternativa eficiente en pacientes donde está contraindicada la cirugía, para mitigar el dolor restaurar los rangos de movimiento y recuperar la funcionalidad alterada.
Apnea obstructiva del sueño y terapia miofuncional orofacial
Authors: Parra-Reyes David , Sanzana-Leiva Andrés
Published: January 2025

Objetivo: dar a conocer las intervenciones realizadas en TMOque existen al momento en pacientes adultos diagnosticados con apnea obstructiva del sueño. Métodos: la búsqueda se realizó en bases de datos PubMed, Google Scholar, Scielo, Science Direct, Cochrane y BVS con los términos Mesh de “Obstructive Sleep Apnea”, “Myofunctional Therapy, y “Speech Therapy”. Siendo seleccionados un total de 12 artículos originales de 2003 a 2023 con varias intervenciones en terapia miofuncional orofacial. Resultados: el fortalecimiento muscular de la vía aérea superior, mediante esta intervención fonoaudiológica, genera beneficios y mejoras significativas sobre los signos y síntomas del SAOS. Además de mejora subjetiva de la somnolencia diurna y de la calidad del sueño. Se evidenció también mejoras significativas en la circunferencia de cuello, apnea presenciada e intensidad de ronquidos. Conclusión: todos los artículos del estudio exponen aplicar diversas intervenciones en terapia miofuncional y afirman mejoría en la calidad del sueño nocturno, influenciando en la disminución de la somnolencia diurna, un aumento en el tono muscular orofaríngeo, reducción de la gravedad del SAOS y en general una mejora la calidad de vida de los sujetos investigados.
Efectividad de las ondas de presión radial en epicondilalgia lateral en pacientes físicamente activos: a propósito de dos casos
Authors: Porras-Balladares Esteban José , Centeno-Ávila María Eugenia , Rivera-Vargas Juan Miguel
Published: January 2025

La epicondilalgia lateral o codo de tenista representa una de las lesiones más comunes del complejo articular del codo, siendo el microtraumatismo repetitivo la principal causa de lesión. El abordaje no operatorio por medio de Ondas de choque extracorpóreas (ESWT) es el tratamiento fisioterapéutico ideal en las tendinopatías crónicas. El presente reporte de casos tiene como objetivo justificar una propuesta fisioterapéutica realizada en dos pacientes físicamente activos de 62 y 57 años, conocidos como sanos, con sintomatología de dolor, reducción funcional y disminución de la fuerza prensora. Ambos presentaron epicondilalgia lateral debido a la sobrecarga de la musculatura extensora del carpo secundaria a la actividad física. Posterior a la evaluación fisioterapéutica que incluyó pruebas especiales, valoración funcional y de la fuerza de prensión fue aplicado un protocolo de ESWT una vez a la semana, con una dosificación inicial de 2,5 bares y final de 4,7 bares, con 2000 disparos en cada sesión, los pacientes tuvieron entre 3 a 6 sesiones en total. Ambos pacientes tuvieron una recuperación total del dolor, pruebas especiales finales negativas, mejoría total en la fuerza de prensión y capacidad funcional. Se concluye que el tratamiento fisioterapéutico con ESWT en epicondilalgia lateral es una alternativa eficaz de primera línea para la reducción de signos y la recuperación funcional completa de pacientes con ese padecimiento.
Efecto de un programa de ejercicio aeróbico más fuerza con dos modalidades de entrenamiento de Rehabilitación Cardiovascular Fase II, sobre la composición corporal de adultos mayores con enfermedad cardiovascular
Authors: Heyden-López Franklin
Published: January 2025

Introducción: las enfermedades cardiovasculares presentan la primera causa de muerte a nivel mundial y nacional. La rehabilitación cardiovascular es un proceso terapéutico que reduce síntomas, número de hospitalizaciones, morbi-mortalidad, mejora la capacidad y tolerancia al ejercicio, mejora nivel de lípidos en sangre, mejora la capacidad funcional, la calidad de vida y el bienestar psicológico de las personas con Enfermedad cardiovascular. A nivel nacional los programas de rehabilitación cardiovascular tradicionalmente incluyen la educación sanitaria enfocado en el control de factores de riesgo cardiovasculares, el entrenamiento físico, con trabajo aeróbico más la intervención psicosocial, sin incluir el componente de fuerza. Este estudio intenta identificar el Efecto de un programa de ejercicio aeróbico más fuerza con dos modalidades de entrenamiento de Rehabilitación Cardiovascular Fase II, sobre la composición corporal de adultos mayores con enfermedad cardiovascular. Metodología: este trabajo corresponde a estudio observacional descriptivo, retrospectivo. Se tomaron los resultados pre y post de 199 registros de adultos mayores que participaron del Programa de Rehabilitación Cardiovascular Fase II del Hospital Nacional de Geriatría y Gerontología, entre 2014 y 2019. El programa consistió en dos grupos que realizaron 24 y 32 sesiones de trabajo que incluyó, trabajo aeróbico y fuerza muscular. Se realiza un análisis de varianza ANOVA mixto para cada variable. Se estableció una significancia estadística de p≤0,05. Resultados: composición corporal (el índice de masa corporal mejoró un -0,28% con magnitud de cambio de -0,08 kg/m2, p=0,002; el porcentaje de grasa general mejoró en un -1,54% con magnitud de cambio de -0,48%, p<0,001; porcentaje de músculo mejoró 1,16% con magnitud de cambio de 0,34%, p<0,001). Conclusión: se concluye que un programa de ejercicio aeróbico más fuerza de 32 sesiones de rehabilitación cardiovascular fase II podría mejorar la composición corporal de adultos mayores con enfermedad cardiovascular.
Three-Dimensional Printed Cell-Adaptable Nanocolloidal Hydrogel Induces Endogenous Osteogenesis for Bone Repair
Authors: Lu Wenxin , Li Li , Wang Ruyi , Wu Yanting , Chen Yao , Tan Bowen , Zhao Zhihe , Gou Maling , Li Yu
Published: January 2025

Repairing critical bone defects remains a formidable challenge in regenerative medicine. Scaffolds that can fill defects and facilitate bone regeneration have garnered considerable attention. However, scaffolds struggle to provide an ideal microenvironment for cell growth and differentiation at the interior of the bone defect sites. The scaffold’s structure must meet specific requirements to support endogenous bone regeneration. Here, we introduce a novel 3D-printed nanocolloidal gelatin methacryloyl (GelMA) hydrogel, namely, the nG hydrogel, that was derived from the self-assembly of GelMA in the presence of Pluronics F68, emphasizing its osteoinductive capability conferred solely by the specific nanocolloidal structure. The nG hydrogel, exhibiting remarkable pore connectivity and cell-adaptable microscopic structure, induced the infiltration and migration of rat bone mesenchymal stem cells (rBMSCs) into the hydrogel with a large spreading area in vitro. Moreover, the nG hydrogel with interconnected nanospheres promoted the osteogenic differentiation of rBMSCs, leading to up-regulated expression of ALP, RUNX2, COL-1, and OCN, as well as augmented formation of calcium nodules. In the critical-sized rat calvarial defect model, the nG hydrogel demonstrated improved repair of bone defects, with enhanced recruitment of endogenous CD29
+
and CD90
+
stem cells and increased bone regeneration, as indicated by significantly higher bone mineral density (BMD) in vivo. Mechanistically, the integrin β1/focal adhesion kinase (FAK) mechanotransduction signaling pathway was up-regulated in the nG hydrogel group both in vitro and in vivo, which may partially account for its pronounced osteoinductive capability. In conclusion, the cell-adaptable nG hydrogel shows great potential as a near-future clinical translational strategy for the customized repair of critical-sized bone defects.
Heart Failure and Gut Microbiota: What Is Cause and Effect?
Authors: Shen Shichun , Tian Beiduo , Zhang Haizhu , Wang Yu-Chen , Li Tao , Cao Yang
Published: January 2025

Emerging evidence highlights the central role of gut microbiota in maintaining physiological homeostasis within the host. Disruptions in gut microbiota can destabilize systemic metabolism and inflammation, driving the onset and progression of cardiometabolic diseases. In heart failure (HF), intestinal dysfunction may induce the release of endotoxins and metabolites, leading to dysbiosis and exacerbating HF through the gut–heart axis. Understanding the relationship between gut microbiota and HF offers critical insights into disease mechanisms and therapeutic opportunities. Current research highlights promising potential to improve patient outcomes by restoring microbiota balance. In this review, we summarize the current studies in understanding the gut microbiota–HF connection and discuss avenues for future investigation.
Application of Optimal Control Strategies on Incidence of Medical Complications in Diabetic Patients’ Population
Authors: Aye P. O. , Jayeola D. , Akintunlaji I. D. , Adegbite B. E.
Published: January 2025

Diabetes mellitus is a chronic condition characterized by elevated blood glucose levels, which can lead to severe health complications if not properly managed. The increasing prevalence of diabetes worldwide has made it a major public health concern. This study formulates and analyzes an optimal control model for diabetes management, focusing on minimizing complications and treatment costs. The model is structured around a population of diabetic patients, incorporating dynamic interactions between healthy, susceptible, diabetic, complication, and treatment populations. An objective functional is defined, integrating costs associated with complications and treatment efforts, and is subjected to optimization through control strategies aimed at enhancing patient education, regular monitoring, and comprehensive care. The application of the Pontryagin Maximum Principle provides a solid theoretical foundation for identifying optimal control strategies. Utilizing a fourth-order Runge-Kutta method, the model is simulated under varying control conditions to assess the impact of interventions. The results demonstrate that increasing control measures significantly reduces the incidence of complications while improving treatment rates. The findings highlight the importance of strategic health management interventions in mitigating the burden of diabetes-related complications and emphasize the model's applicability in real-world healthcare settings. This research provides a robust framework for policymakers and healthcare providers to devise effective strategies that enhance the quality of care for diabetic patients.
Avrupa İnsan Hakları Mahkemesi'nde İklim Değişikliği Davaları
Authors: Çakan Seher
Published: January 2025

İklim değişikliğinin olumsuz etkilerinden dolayı hak temelli iklim davaları hem ulusal hem de uluslararası mahkemeler aracılığıyla açılmıştır. Avrupa İnsan Hakları Mahkemesi 9 Nisan 2024’te vermiş olduğu üç kararla ilk kez iklim değişikliğine ilişkin karar vermiş oldu. Mahkeme görülen davadan ikisinin, Duarte Agostinho ve diğerleri v Portekiz ve 32 diğer devlet ve Carême v Fransa davaları kabul edilemez olduğuna karar vermiştir. Verein Klimaseniorinnen Schweiz ve Diğerleri v İsviçre davası da Mahkemenin hak ihlali vermiş olduğu ilk karardır.
Her üç kararda da Mahkeme iklim değişikliğine ilişkin bazı hususları açıklığa kavuşturmuştur. Mahkeme bu kararlarda iklim değişikliği davalarının ülke dışı yarı yetkisi kapsamında olup olmadığını, devletlerin takdir marjı, mağdur statüsü gibi önemli konuları ele almıştır. Özellikle de 8. Madde kapsamında pozitif yükümlülüklerin ve mağdur statüsünün kapsamlarının genişletilmesi önemlidir. Bu çalışmanın amacı AİHM’nin vermiş olduğu bu kararlar çerçevesinde iklim değişikliği davalarında tartışmalı olan bazı hususları ele alarak iklim değişikliğine ilişkin bu kararları detaylı bir şekilde incelemektir.
Avrupa Birliği Yapay Zekâ Kanunu’nun Risk Grupları ve İlgililerin Yükümlülükleri Bağlamında İncelenmesi
Authors: Karadeniz Salih
Published: January 2025

Avrupa Birliği, gelişen teknolojiler bakımından yapmış olduğu regülasyon çalışmaları ile ön plana çıkmaktadır. Avrupa Birliği Yapay Zeka Kanunu da bu regülasyon çalışmalarından sadece birisidir. Bu doğrultuda Avrupa Birliği, temelde birlik içerisinde ve birlik üyesi devletlerin vatandaşlarını etkileyen bir durumun varlığında, uygulanmak üzere bir yapay zeka kanunu oluşturmuştur. Yapay zekanın ilk defa kapsamlı olarak ele alındığı bu kanunda, yapay zeka sistemleri Avrupa Birliği tarafından risk temelli yaklaşım çerçevesinde ele alınmıştır. Yasaklı, yüksek riskli, sınırlı riskli ve minimum riskli sistemler olarak dört grupta sınıflandırılan yapay zeka sistemleri, birliğin çıkarları doğrultusunda düzenlenmiş, bu sistemleri sağlayanlara, distribütörlere, ithalatçılara ve kullanıcılara çeşitli yükümlülükler öngörülmüştür. Kanunun kapsamı ise oldukça geniş tutulmuştur. Dünyada ilk olduğu kabul edilen Avrupa Birliği Yapay Zeka Kanunu, önemine binaen işbu çalışmada detaylı bir şekilde ele alınacaktır.
Afet Yönetimi; Devletin Pozitif Yükümlülüğü ve İdarenin Sorumluluğu
Authors: Gökalp Süheyla Suzan , Çolakoğlu Melike
Published: January 2025

Ülkemiz doğal afetler sebebiyle yüksek risk grubundaki ülkeler arasında bulunmaktadır. Türkiye deprem, heyelan, sel, çığ gibi pek çok doğa kaynaklı afetle karşı karşıya kalmaktadır. Doğal afetler; bireylerin yaşam hakkı, mülkiyet hakkı gibi en önemli temel haklarını etkileyebilmekte ve bu konuda devlete düşen önemli yükümlülükler bulunmaktadır. Avrupa İnsan Hakları Mahkemesi ve Anayasa Mahkemesi’nin bu konuda vermiş oldukları ihlal kararları yol gösterici niteliktedir. Hukuk devletinin en önemli unsurlarından biri idarenin mali sorumluluğudur. Anayasa’nın 125. Maddesi ile idare vermiş olduğu zararları tazmin etmekle yükümlüdür. Doğal afetler sebebiyle idari yargı kararlarında idarenin hizmet kusuru nedeniyle sorumlu tutulduğuna ilişkin pek çok karar bulunmaktadır. İdarenin doğal afet sırasında ve sonrasındaki işlemleri ile mücbir sebep teşkil eden olayların idarenin sorumluluğuna etkisi tartışılmış ve yeni bir sorumluluk anlayışının kabul edilmesi gerektiği öngörülmüştür. Ayrıca sorumluluğun tartışılması gereken en önemli hususlarından biri idarenin denetim ve gözetim yetkisini yerine getirmemesi ve yapı denetim şirketlerine devretmesidir. Bu husustaki Anayasa Mahkemesi kararı da önem arz etmektedir. Çalışmamızda idarenin doğal afetler nedeniyle sorumluluğu konusu mevzuat, idari yargı ve Anayasa Mahkemesi kararları çerçevesinde incelenmiş, idarenin sorumluluğuna ilişkin öneriler sunulmuştur.
Toplu İş Hukuku Perspektifi İle İklimin Korunması
Authors: Ayan Hasan Alparslan
Published: January 2025

İklim değişikliği, eski ancak etkisi şimdi ortaya çıkan ve günümüzde tekrar dikkat çekmeye başlayan bir konudur. İklim değişikliğinin etkisini ortadan kaldırmaya yönelik çözüm önerileri, ilk kez kamu hukuku içerisinde araştırılmış, ne zaman ki çözüm önerileri yetersiz kaldığı anlaşılmış, bu sefer özel hukuk içerisinde çözüm için araçlar geliştirilmeye çalışılmıştır. Çalışma kapsamında cevabını aradığımız soru, iklimin korunmasında, toplu iş hukuku araçlarının kullanılıp kullanılamayacağı olmuştur.

İklim değişikliğinin etkisinin ortadan kaldırılması yahut azaltılabilmesi için toplu iş hukuku araçları kullanılabilir. Bu fikir ile, öncelikle iklim krizinin önemi açıklanmalı, sonrasında toplu iş hukukuyla ilişkisi ortaya konmalı ve sosyo-ekolojik açıdan değerlendirilmesi yapılmalıdır.

İklimin korunmasının toplu iş hukuku perspektifi ile değerlendirilmesinde, üç ana başlık bulunmaktadır. Bunlardan birincisi, iklim dostu düzenlemelerin oluşturulması için toplu iş sözleşmelerinin kullanılmasıdır. İkincisi, iklimin korunmasına yönelik gerçekleştirilen ulusal ve uluslararası iklim eylemlerinin, toplu eylem hakkı içerisinde ele alınmasıdır. Üçüncüsü ise, iklimin korunmasında işçilere ortak karar alma hakkının tanınmasıdır. Bu çerçevede çalışmanın nihai amacı, disiplinler arası bakış açısıyla, acilen ihtiyaç duyduğumuz ekolojik dönüşüm için verilen çabalara, toplu iş hukuku cephesinden katkı sunmaktır.
Belediye Başkan Yardımcılığının İdare Hukuku Açısından Değerlendirilmesi
Authors: Tokgöz Hikmet
Published: January 2025

5393 sayılı Belediye Kanunu’na göre norm kadrosunda belediye başkanı bulunan belediyelerde bu kadrolara atanmak suretiyle göreve gelen başkan yardımcısı ile bu kadrolara bağlı olunmaksızın belediye meclisi üyeleri arasından görevlendirilebilen başkan yardımcısı olmak üzere iki tür belediye başkan yardımcılığı vardır. Meclis üyeleri arasından başkan yardımcısı olarak bir üyenin görevlendirilebilmesi ilk defa mülga 1580 sayılı Belediye Kanunu döneminde söz konusu olmuştur. Her ne kadar yürürlükteki Kanun gerekçesinde bu hususun yeniden düzenlenerek devam ettirildiği belirtilse de önceki dönemden beri devam edegelen problemler söz konusudur. Çalışmada başkan yardımcılarının hukuki statüsü tespit edilecektir. Onların göreve gelmeleri ve görevden alınmaları hususu da ayrıca incelenecektir. Son tahlilde, konuya ilişkin mevzuat düzenlemelerinin yetersiz olduğu belirtildikten sonra buna ilişkin çözüm önerileri sunulacaktır.
Survival Analysis of Transfer Students
Authors: Zhou Shulin , Li Yihui , Neverett Margot , King Beverly , Chapman Kyle , McNair Sharon
Published: January 2025

Research conducted on transfer student outcomes consistently shows that there is a bachelor’s degree
completion gap between transfer students and nontransfer students. Researchers have explored several
factors thought to impact bachelor’s degree completion for transfer students, including demographic
characteristics, number of credit hours transferred, transfer GPA, transfer institution type, and indicators of
academic achievement. The findings from these studies have not always been consistent in whether (or how)
these factors influence degree completion. The current study uses survival analysis to better understand
college persistence for students transferring to a large, 4-year, public university located in the Southeast
United States. Survival analysis, a statistical technique underutilized in higher education research, has several
advantages over more traditional methods, such as regression. For example, survival analysis not only has the
capacity to examine time-varying predictors, but also can include both uncensored and censored events (i.e.,
it can handle both students for whom the event of interest occurs during the time frame under investigation
and students for whom it does not). In addition to variables explored in previous research, this study
investigated aspects of students’ majors (i.e., whether they changed majors after enrollment and whether
majors were in STEM fields). Findings indicate that transfer students who are most likely to persist are
generally younger, are full-time students, and are in STEM majors; and that they have higher prior academic
achievement, a greater numbers of transfer hours, and at least one major change.
Language and Liberty: Leveling The Playing Field for Liberalism
Authors: Falcone Marcos
Published: January 2025

Classical liberals and libertarians engage in public debates that are often biased against them. Intentional changes in language with the goal of discrediting classical liberalism have occasionally been recognized by its intellectuals, most notably Ludwig von Mises, Friedrich A. Hayek, and Bruno Leoni. This article breaks down various linguistic transformations and proposes strategies to level the playing field in public debates and move liberals to a better rhetorical position from which to engage their intellectual rivals. These strategies can be grouped into three categories: (1) the rejection of concepts created with the goal of discrediting liberalism; (2) the vindication of classical liberal meanings of key philosophical ideas; and (3) the creation of new, “liberal-friendly” conceptualizations to advance liberalism with a focus on visual thinking.
Diseño y validación de instrumento para caracterizar la gestión sostenible de los espacios verdes urbanos
Authors: Manuari-Cubas Lolita , Dávila-Cisneros Juan Diego , Vela-Meléndez Lindon , Bueno-Fernández Mario Mitsuo
Published: January 2025

El objetivo de este trabajo es desarrollar un instrumento para caracterizar la gestión sostenible de los espacios verdes urbanos. La investigación realizada tiene un carácter no experimental, de tipo descriptivo, con enfoque cuantitativo dado que sus indicadores son valores medibles numéricamente. Para la validación de la encuesta se elaboró un pretest basado en la literatura y criterio de expertos y se aplicó al 10% de la muestra original. Al aplicarlo se pudo identificar que el 73,13% del enunciado de las preguntas estaban correctamente elaboradas facilitando la rápida comprensión por el usuario fomentando una respuesta directa y rápida. Los resultados del alfa de Cronbach mostraron un valor 0.924 en el análisis de todos los ítems. La prueba de Chi-cuadrado determinó que existe una relación entre la gestión ambiental sostenible y las áreas verdes urbanas. La encuesta quedó determinada por 45 ítems.
Propuesta de champú sólido sostenible con propiedades antioxidantes con extracto de hibiscus sabdariffa
Authors: Rodríguez-Almeida Nancy Narcisa , Dahua-Gualinga Ruth Dayra , Rivera-Rojas Fanny Noemi , Rivera-Barreto Jannys Lizeth
Published: January 2025

Este estudio investiga el desarrollo de un champú sólido formulado con base de champú y extracto acuoso de Jamaica, evaluando su actividad antioxidante mediante el método FRAP. Se analizaron diez formulaciones con diferentes proporciones de estos componentes. Los resultados mostraron que las formulaciones con mayor porcentaje de extracto, específicamente las formulaciones 2 y 8 (75% base y 25% extracto), presentaron las actividades antioxidantes más elevadas, alcanzando 5,39 y 5,42 eq. Trolox/g, respectivamente. En contraste, las formulaciones compuestas únicamente por base de champú carecieron de actividad antioxidante, subrayando la importancia del extracto de Jamaica para mejorar estas propiedades. La ecuación del modelo ajustado indicó que la actividad antioxidante está influenciada por las proporciones de los ingredientes y su interacción. La formulación óptima identificada consiste en un 75% de base de champú y un 25% de extracto de Jamaica, lo que potencializa significativamente las propiedades antioxidantes del champú sólido desarrollado.
El derecho fundamental a la seguridad alimentaria en Latinoamérica. Un estudio comparado
Authors: Bueno-Fernández Mario Mitsuo , Salazar-Echeagaray Teresa Irina , Carrasco-Valenzuela América Cynthia , Hagelsieb-Dórame Luis Alonso
Published: January 2025

Desde principios del presente siglo, temáticas vinculadas a la seguridad alimentaria han ido tomando fuerza. De esta forma, en el presente artículo se plasma un análisis del marco legal sobre la seguridad alimentaria en América Latina mediante un estudio comparativo en ocho países: Guatemala, Brasil, Venezuela, Ecuador, Nicaragua, Honduras, Perú y México. Por lo que, el objetivo es evaluar cómo estas legislaciones garantizan el derecho a la alimentación, identificando similitudes, diferencias y desafíos en su implementación. Para ello, se ejecutó un estudio con un enfoque cualitativo, donde la revisión documental fue empleada como principal recurso metodológico. El análisis revela avances significativos, como la consolidación de sistemas intersectoriales y el fortalecimiento de la agricultura sostenible, aunque persisten retos estructurales como la pobreza, la desigualdad, las crisis políticas y los efectos del cambio climático. Así, las normativas estudiadas promueven políticas públicas destinadas a la disponibilidad, accesibilidad y sostenibilidad alimentaria, con énfasis en sectores vulnerables.
Promoción de habilidades blandas en estudiantes universitarios a través de las prácticas de enseñanza: validación de un instrumento
Authors: Islas-Torres Claudia , Franco-Casillas Sergio , Carranza-Alcántar María del Rocío
Published: January 2025

Currently, in various fields, the demonstration of soft skills by individuals is highly valued, which is why university training processes must aim to enhance these skills among students. In this regard, a cross-sectional analytical study was developed under a holistic approach, aiming to analyze the alignment between university teaching practices and the promotion of students' soft skills. A survey-type instrument was created to capture students' perceptions regarding this relationship. The validation process of the instrument, which was completed by 1,677 participants from various undergraduate programs at a university center in western Mexico, is presented. The content validity index obtained from expert judges was 0.837, while Cronbach's alpha was 0.907. Bartlett’s test of sphericity and the Kaiser-Meyer-Olkin (KMO) measure of sampling adequacy were applied for exploratory factor analysis, resulting in a p-value of 0.001 and a global KMO of 0.957, indicating that the data were optimal. The analysis confirmed the grouping of five factors represented in the operationalization synergies. As a result, adjustments were made to the items, discarding those with a factor loading below 0.5 for not providing significant information to the instrument. This led to a reconfiguration, reducing the total items from 44 to 23, which measure the construct defined in the study in greater depth.
Diagnósticos de enfermagem em gestantes hipertensas
Authors: Reiners Annelita Almeida Oliveira , Dióz Majoreth , Teixeira Neuma Zamariano Fanaia , Gonçalves Priscila Maria da Silva
Published: January 2025

This is a descriptive and exploratory study that aims to assess the most frequent nursing diagnoses among pregnant patients with hypertension from a public hospital. Ten pregnant patients underwent a semi - structured interview and a physical examination. Data collection tools were based on Gordon's Functional Health Patterns. Data were analyzed, categorized and synthesized following the hypothetical-deductive model of Gordon. Thirteen diagnoses were identified. The most frequent ones were: poor knowledge about the health problem; ineffective health maintenance; ineffective management of therapeutic regimen; anxiety; disturbed sleep pattern; disturbed body image; altered sexuality patterns and fluid volume excess. These results show us the main nursing problems that pregnant women with hypertension present. It also points out the need to improve health education practices in this population.
A Consulta ginecológica sob a ótica de adolescentes: uma análise compreensiva
Authors: Domingos Selisvane Ribeiro da Fonseca , Madeira Anézia Moreira Faria
Published: January 2025

The purpose of this study was to understand the meaning given by adolescents to a gynecological consultation. I have used a phenomenological approach, according to the concepts of Merleau-Ponty. Data was collected using an open interview. The discourse of the teenagers allowed me to construct three categories: "Expression of Feelings", "Health Care" and "Relation to the health care professional", which show that the consultation brings about embarrassment for them, because they have to talk about their intimacy and expose their bodies for examination, but they manage to overcome these feelings because they recognize it is important to care for their health.
Tipos de tumores incidentes em pacientes cadastrados no Centro de Oncologia e Radioisótopos do Vale do Aço
Authors: Oliveira Thaline Alves de , Salviano Trycia Martins , Oliveira Júnior Pedro Paulo
Published: January 2025

In Brazil, there is a lack of statistics on the prevalence of cancer, making it difficult to see its effects on the population. This study analyzed the kinds of tumors in patients in the oncology and radioisotope center of Vale do Aço, in Ipatinga, state of Minas Gerais, correlating with the mean age of the patients. The results show the greatest prevalence of breast, prostate and uterus tumors, and a wide variation in patients' ages. Prostate tumors are typical of elderly patients, contrasting with breast cancer, which affected women as young as 28 years old.
Análise do conceito de grupo como estratégia para o cuidado de enfermagem
Authors: Monteiro Maria Adelane Alves , Pinheiro Ana Karina Bezerra , Leitão Glória da Conceição Mesquita
Published: January 2025

The group work brings benefits as a strategy for the nursing action. This study aimed to analyze the group concept and to analyze as the nursing is developing work with groups. It is a bibliographical revision to guide the development of a research project about how the group can contribute to the nursing care given to women in the puerperal period who are accompanying their hospitalized children. Considering that the nursing has already been using the group with methodological resource, it is necessary that this continues being investigatted so that it can contribute in a more concrete way to the nursing practice.
Kajian kandungan proksimat udang vaname (Litopenaeus vannamei) dari berbagai pemberian probiotik
Authors: Bastian Fahmi Yudas , Hudi Lukman , Saidi Ida Agustini , Budiandari Rahmah Utami
Published: January 2025

The purpose of the research to determine the effect of probiotics on the proximate content of vaname shrimp (Litopenaeus vannamei). This Research used CRD (Completely Randomized Design) with treatments including P1: conventional cultivation (without probiotics), P2: Probiotic Bio Lacto, P3: Tricodherma sp, P4: GSO4 Probiotic, P5: Tricodherma sp + Probiotic GSO4, and P6: Tricodherma sp + Probiotic Bio Lacto which was done 3 times. Data were analyzed using ANOVA followed by BNJ 5%. The results showed that giving probiotics to vaname shrimp only significantly affected the fat content, while it had no significant effect on water content, ash content, protein and carbohydrate content. The results of the data obtained on the fat content of the lowest value in the treatment of probiotics GSO4 with a value of 1.16 ± 0.14%, and the highest value in the treatment of probiotics Bio Lacto with a value of 4.18 ± 0.76%.