bluuebunny/crossref_metadata_2025 huggingface dataset:
The specifics of the subjects of crimes with administrative prejudice in the field of road safety
Authors: Erte Daria
Published: April 2024

The subject of this study is the key features of the perpetrators of crimes against road safety, the legal construct of which is made using administrative law. The special status of persons committing crimes of this kind is emphasized by gross disregard for the rules established by law, disregard for the regulations in force against them. Based on the analysis of statistical indicators of road traffic accidents caused by drivers of vehicles, the public danger of committing such criminal acts is justified. These acts imply the onset of criminal consequences only if the person who committed them has special features. The emphasis in this case is on the increased danger of the subjects themselves committing intentional violations of traffic rules, referring them to the malicious type of violators with legal nihilism. To define the concepts of this study, a dialectical methodology was used; in order to comprehensively understand the key features of subjects of crimes with administrative prejudice in the field of road safety, elements of sociological methodology were used. In the study of individual issues, private scientific methods were used, such as formal legal and comparative legal. The results of the conducted research are presented by the classification of signs possessed by the subjects of crimes with administrative prejudice in the field of road safety, their characteristics are given. The connection between the administrative prejudice and the subject as an element of the corpus delicti is substantiated, which, first of all, is justified by the assessment of the social danger of the offender and the choice of a preventive measure commensurate with the social danger of the offender. An important role in assessing public danger is played by determining the psychological portrait of the person who committed the crime, which covers the chronology of his administrative offenses and the frequency of violations of the same prescription. Based on the data obtained about the subject of the crime, the principles of proportionality of punishment and personal responsibility are implemented. In this case, these principles imply the influence of administrative prejudice on the fair distribution of sanctions, and previous administrative offenses aggravate the responsibility of the person.
Health damage caused as a result of adverse environmental impacts: civil compensation mechanisms
Authors: Kolesnichenko Ol'ga Viktorovna
Published: April 2024

The subject of research in this article is the regulations and theoretical ideas about compensation for harm caused to a citizen’s health as a result of adverse environmental impacts. The purpose of the study is to create doctrinal conditions and develop proposals for the development of civil legislation aimed at ensuring compensation for harm caused by damage to health in the environmental sphere. As a result of the study, it was proved that in order to ensure real compensability of harm to health in the environmental sphere, the presumption of environmental danger of certain types of economic activity should be accompanied by the legal establishment of an irrefutable presumption of the origin of physical harm from adverse environmental impacts, based on available knowledge about the causes and symptoms of environmentally caused diseases (medical criterion), whether the victim belongs to a risk group based on living or working in the contaminated area (legal criterion). However, the author does not limit himself to justifying the need to introduce this presumption, but proposes a set of measures for the accompanying development of legislation. It is noted that the irrefutable presumption of the origin of physical harm from adverse environmental impacts must be accompanied by the establishment of an obligation of business entities to create conditions for the implementation of non-tort forms of compensation, alternative to insurance compensation within the framework of liability insurance. In this capacity, agreements on the distribution of risks can act, the terms of which provide for the creation of a quasi-insurance public benefit fund, payments from which will repay obligations to victims in an amount that allows taking into account the loss of ability to do paid work, the need for outside care, etc.
The current state of the wine market in Russia
Authors: Pavlova Tatyana Alexandrovna , Rogovenko Natalya Sergeevna
Published: April 2024

This scientific article explores the current state of the winemaking market in Russia. Taking into account changing consumer preferences, economic factors and legislative norms, the authors analyze the current situation of the industry, its dynamics and development prospects. The article analyzes the wine industry. The dynamics of the growth of the viticulture industry, the importance of which lies in providing wine producers with wine materials, is considered. The structure and dynamics of sales of wine products are studied both in Russia as a whole and by region. The problem of import substitution in the Russian wine market is considered. The research is based on the analysis of statistical data and marketing research. The article examines the main market trends, including changes in consumer demand, competitive advantages of various segments and opportunities for the development of new production technologies. The presented analysis will help entrepreneurs, investors and regulators to better understand the current situation in the Russian wine market and make informed strategic decisions for the future.   To study the current state of the wine market in Russia, a comprehensive methodological approach was used, including analysis of statistical data, marketing research, interviews with industry experts and analysis of the legislative framework. This approach made it possible to cover various aspects of market dynamics and identify key trends. The scientific novelty of this article lies in an updated analysis of the current state of the wine market in Russia, taking into account the latest trends and changes in the industry. The study includes up-to-date data on consumer preferences, economic factors and legislative impact on the wine market. The conclusions of the article emphasize the increasing demand for high-quality and environmentally friendly wines, the growing interest in local producers and the strengthening of the position of domestic wines in the market. The authors of the article also identified prospects for the development of new production technologies and marketing strategies to attract consumers and investors. In general, the article highlights the importance of adapting the wine industry to changing market conditions and offers practical recommendations for industry participants.
COVID-19 como fator de risco em pacientes com Síndrome de Brugada
Authors: Amaral Jessyca Jocyelle de Almeida , Mendonça Vanessa Lucena Oliveira Lima de , Carvalho Rodrigo Guimarães Vieira De , Barroso Wermerson Assunção
Published: April 2024

Objetivo: Descrever as características da Síndrome de Brugada (SBr) e associar a Covid-19 como um fator de risco. Revisão bibliográfica: A SBr é uma doença rara, genética autossômica dominante, caracterizada pela presença de características eletrocardiográficas específicas com ou sem sintomas clínicos. Tem descrição relativamente recente na literatura médica, pois foi descrita pela primeira vez em 1992, quando os Brugada apresentaram casos recorrentes de morte súbita. Os pacientes geralmente são adultos jovens, com risco elevado de morte súbita por fibrilação ventricular. Possui um tratamento específico, que é o implante de um cardioversor elétrico. Foi observada uma associação entre problemas relacionados à infecção pela COVID-19, como febre, distúrbios eletrolíticos e estresse inflamatório, com sintomas transitórios do tipo Brugada e padrão de Eletrocardiograma (ECG), bem como sua suscetibilidade a episódios pró-arritmogênicos. Considerações finais: Faz-se necessário ampliar o conhecimento sobre esta temática, com dados mais atualizados, para contribuir para o manejo clínico e diagnóstico precoce. O ECG com padrão de Brugada associado à COVID-19 parece relativamente raro e a maioria dos pacientes teve resolução do padrão de ECG, assim que os sintomas melhoraram.
Bolas fúngicas renais em neonatos: ocorrência e caracterização ecográfica
Authors: Ramos Camilo Ferreira , Carneiro Irna Carla do Rosário Souza , Ramos Brenda Prazeres de Campos
Published: April 2024

Objetivo: Investigou-se a ocorrência de bolas fúngicas no sistema urinário de neonatos internatos em terapia intensiva. Métodos: Foi realizado estudo observacional, transversal e descritivo, desenvolvido em hospital terciário em Belém, Brasil, no período de novembro de 2020 a janeiro de 2021, com uma casuística de 150 neonatos e lactentes. Foram selecionados neonatos com evidência laboratorial de infecção fúngica (candidemia e candidúria) e neles foi realizado exame de ultrassonografia do aparelho urinário em busca de complicações fúngicas. Resultados: Identificou-se quatro casos de bolas fúngicas entre os pacientes, além de prevalência estimada em 4% de candidemia entre os pacientes estudados. O perfil mais comum da casuística foi: sexo masculino, muito baixo peso, prematuridade moderada e nascidos de parto cesariano. Conclusão: Pelo curto período estudado, destacou-se o elevado número de casos de bolas fúngicas encontrados, o mesmo quantitativo ou até superior em relação a estudos de longa duração em outros centros, o que exprime a necessidade de triagem dos pacientes e busca ativa por este diagnóstico, a fim de reduzir as complicações e a morbimortalidade associada, sugerindo-se ainda a elaboração de protocolos para tal finalidade com a utilização da ultrassonografia.
Enhancing clinical management of neurological disorders: Feedback from the healthcare provider perspective
Authors: Sultana Safiya , Gite Mrinal Ramdas , Tawde Akshaya Deepak , Jena Chandrakant , Kaushik Shradha , Mahajan Navya , Shah Jaimin , Kapoor Mitali
Published: April 2024

Objectives:

Neurological disorders are a global health concern, and their management requires competent health-care professionals (HCPs). This study aimed to evaluate the current state of neurological case management among Indian HCPs by focusing on different aspects such as frequency of encounters, confidence, and upskilling preferences in managing neurological cases.

Materials and Methods:

A quantitative cross-sectional survey was conducted among 104 HCPs, including general practitioners (GPs) and consulting physicians (CPs). The survey gathered data on the frequency of encountering neurological cases, confidence levels, areas for improvement, preferred upskilling methods, and willingness to seek guidance from neurology experts.

Results:

Of the 104 HCPs surveyed, 69 (66.35%) HCPs frequently encountered neurological cases in their daily practice. Among them, 70.19% expressed a moderate level of confidence in managing such cases. Nearly, all HCPs (99.04%) showed a keen interest in upskilling their expertise in the field of neurology. The preferred approaches for upskilling included case-based learning (38.38%) and online webinars or lectures (38.38%). In addition, they showed a willingness to engage with neurology experts for guidance.

Conclusion:

Our study results highlight the high prevalence of neurological cases in the daily practices of HCPs. The findings reveal that HCPs are moderately confident in managing these cases, underscoring the necessity for targeted interventions to enhance their proficiency. Overall, the study emphasizes the importance of tailored neurological interventions to address the specific needs of Indian HCPs in managing neurological cases.
Relative bioavailability study of ticagrelor in healthy subjects under fasting conditions
Authors: Pena Evelyn , Inatti Alfredo , Taly Anyoli , Serrano Xenón
Published: April 2024

Objectives:

This is a randomized, single-dose, two-period, two-sequence, and crossover study to evaluate the bioequivalence (BE) profiles of two formulations of ticagrelor 90 mg, under fasting conditions.

Materials and Methods:

The plasma concentrations of ticagrelor were measured using a validated liquid chromatography mass spectrometry method. Enrolled for the study were 30 healthy adult volunteers (21 males and 9 females). All completed the study. The two formulations of ticagrelor were considered bioequivalent if a 90% confidence interval (CI) fell within 80.00–125.00% for Cmax and AUC0-t. Tolerability and safety were assessed throughout the study.

Results:

The pharmacokinetic (PK) parameters were similar between the test product (T) Clenosan® and reference product (R) Brilinta® under fasting conditions (90% CI for all PK parameters fell within 80.00–125.00%). The 90% CI of the test/reference ratios of log-transformed PK parameter point estimates were Cmax: 95.49% (87.99– 103.62%) and AUC0-t: 103.20% (97.52–109.21%), respectively.

Conclusion:

Our results demonstrated BE between the test and reference drug products of oral ticagrelor in healthy subjects under fasting conditions.
Pengembangan Inti Bi'ah Solehah di Kolej Universiti Islam Perlis (KUIPs): Satu Gagasan Menurut Al-Quran dan Al-Sunnah
Authors: Bin Yaakob Mohd Aizul , Binti Mohamad Noorkartina , Bin Baharudin Muhammad Asyraf , Binti Aisom Anis Shakira , Binti Shabri Rifhan Syafinaz , Bin Mohd Radzi Mohammad Ammar
Published: April 2024

Bi’ah solehah atau lingkungan yang baik merupakan suatu penyumbang besar dalam pengembangan kepribadian pelajar di suatu institusi. Pengembangan kepribadian pelajar bukan saja dipengaruhi oleh pengajaran dan pembelajaran di dalam ruang kelas saja. Akan tetapi, faktor lingkungan turut mempengaruhi pengembangan kepribadian pelajar. Bagaimanapun, kajian ini mendapati bahwa gagasan dalam pengembangan elemen bi’ah solehah masih belum diperkenalkan dalam berbagai kajian, khususnya dalam pengelolaan perguruan tinggi. Berhubungan dengan hal tersebut, artikel ini bertujuan menyarankan inti utama dalam pengembangan bi‘ah solehah, khususnya di Kolej Universiti Islam Perlis (KUIPs). Kajian ini adalah sepenuhnya bersifat kualitatif dan melibatkan pengumpulan data melalui kaidah dokumentasi dan dianalisis dengan menggunakan kaidah analisis dokumen. Hasil dari kajian menunjukkan sekurang-kurangnya terdapat enam ini utama yang disarankan dalam pengembangan bi’ah solehah di KUIPs, yaitu pembudayaan ilmu, pelaksanaan amar ma‘ruf nahy al-munkar, pergaulan dengan mematuhi syariah, memberdayakan pelaksanaan sholat jama’ah, membentuk komunikasi digital bi’ah solehah dan lingkungan kondusif dan nyaman.
Sports coaching during the pandemic: Predicaments encountered by Filipino physical education teachers and potential strategies
Authors: Angoy Raisalam , Ma'mun Amung , Mahendra Agus , Abduljabar Bambang
Published: April 2024

Background Problems: The educational disruptions and suspension of athletic competitions caused by the COVID-19 pandemic presented sports coaches with unique challenges in maintaining coaching and training activities for the athletes. Research Objectives: This study aimed to gain a comprehensive understanding of the experiences of physical education teachers who are also coaches in sports coaching amidst the COVID-19 pandemic. Methods: The study was qualitative, utilising a descriptive phenomenological design. Five participants willingly took part in an in-depth interview, ensuring the protection of informant data and maintaining anonymity. The instrument used was a semi-structured interview guide recorded via video and transcribed using Microsoft Word. Informed consent was obtained before the interview, and data analysis followed Collaizi's descriptive phenomenology for collecting, reducing, presenting, verifying, and concluding the data. Findings/Results: The findings of the study revealed several sports coaching predicaments: connectivity and communication issues, physical training conflict, administrative concerns, and psychosocial problems. Additionally, potential strategies were also revealed: connectivity and communication strategy, modified training method, administrative outsourcing initiative, and psychosocial initiative. Based on the results of the study, a proposed sports coaching intervention plan is highly recommended for utilisation to address several predicaments that emerged. Conclusion: Research shows that in grappling with pandemic-related challenges, coaches play a crucial role in maximising athletes' potential, necessitating a blend of skills and emotional resilience as they formulate effective coaching strategies for the predicaments encountered. Generally, this can contribute to more effective and well-rounded sports coaching, ultimately benefiting the athletes and the overall success of sports coaching and the school's sport-related programmes.
On the functioning of the Law «On Languages in the Republic of Sakha (Yakutia)» in the city of Yakutsk (based on the results of the questionnaire on Articles 19-23, 33)
Authors: Sobakina I. V.
Published: April 2024

In modern times, the functioning of languages in public space requires state regulation, the main goal of which should be the preservation and development of multilingualism and support of minority languages. The national politics in the field of preservation and development of the languages of the peoples of the Russian Federation is based on the implementation of a number of measures at the legislative level. Russia adopted the Law “On the Languages of the Peoples of the Russian Federation”; its national republics have their own laws on languages regulating the functioning of languages on their territory. In Yakutia, on October 16, 1992, Law of the Republic of Sakha (Yakutia) No. 1170-XII “On languages in the Republic of Sakha (Yakutia)” was adopted, a study on the implementation of which became one of the projects of the state program of the Republic of Sakha (Yakutia) “Preservation and development of state and official languages in the Republic of Sakha (Yakutia) for 2023.” The project “Monitoring the implementation and compliance with the requirements of articles of the Law on Languages in Yakutsk of the Republic of Sakha (Yakutia)” was proposed by the Department of Stylistics of the Yakut Language and Russian-Yakut Translation of the Institute of Languages and Culture of the North-East of the Russian Federation of the M.K. Ammosov North-Eastern Federal University. In order to implement the project, the department’s team developed a questionnaire on the articles of the Law “On Languages in the Republic of Sakha (Yakutia)” for two target audiences: specialists from organizations to whose work the articles of the Law are directly related, and the population. The purpose of the proposed work is to analyze the results of a survey conducted on articles 19, 20, 21, 22, 23, 33 among specialists of organizations and the population of the city of Yakutsk. The study used statistical and descriptive methods, as well as data processing and analysis methods. The results of the study are structured as follows: first, the full text of the considered article of the Law “On Languages in the Republic of Sakha (Yakutia)” is presented, then an analysis of a survey among employees of the institution and the results of a survey among the population are presented, followed by recommendations for the implementation of the article of the Law.
Formant indicators of «velarization». Part I
Authors: Urtegeshev N. S.
Published: April 2024

This article discusses the problem of determining velarization from acoustic data and its relationship to articulation. The aim of the study is to identify the range of formants by which «velarization» can be determined, as well as to determine the location of the highest point of localization of the part of the back of the tongue of the relative palatine arch with this articulation, modeling the sound quality of a specific consonantal sound type. In the course of the study, the methods used at the V.M. Nadelyaev LFEI of the sector of languages of the peoples of Siberia of the IFL SB RAS (Novosibirsk), as well as in the LEFI of the Department of Foreign Languages of the AmSU (Blagoveshchensk). The object of the study is dynamic speech. The subject of the study is «velarization» in languages of different families. The material for the analysis was static and dynamic MRI scans and audio recordings recorded at different times by employees (including the author of this work) of the V.M. Nadelyaev LEFI, made on time and after tomography from the appropriate media. Scientific novelty and theoretical significance of the study: the correlation between F2 , articulation and auditory perception of amplifying articulation of hardness – “velarization” is presented for the first time. The materials and results of the research can be used to develop textbooks on general phonetics, at seminars on dynamic speech analysis, and when writing scientific articles on experimental phonetics. The main conclusions presented in this paper are: 1) the acoustic effect of “velarization” is achieved not only as a result of lifting the back of the tongue to the soft palate not in guttural consonants (velarization), but also between the last third of the second half of the hard palate (prevelarization); 2) correlation analysis of somatic and acoustic material revealed the dependence of format indicators on a certain articulation; 3) a possible range of “velarization” in consonants has been identified – F2 = 1500 Hz – 550 Hz; 4) in the range from 1500 Hz to 1301 Hz, velarization sounds slightly “softer” by ear – a prevelarized consonant than from 1300 Hz to 550 Hz – a velarized consonant.
On the question of the authenticity of the language of the Buryat epic
Authors: Tagarova T. B.
Published: April 2024

The purpose of this article is to identify the basic linguistic markers of text authenticity, which is important when studying dialects and literary language. The content and form of the authentic text is determined by the narrator’s dialect transmission and the collector’s recording process. When a text is realized through language, differences appear in the lexical composition of the version of the source epic and the literary form of the language of the person recording it. As part of the observation, it was established that there is a connection between the authenticity of the text and the choice of lexical means, language norms, meaning, and function of the original source. Lexical units show differences in semantics and material sound shell.
استراتيجية التمكين الاداري ودورها في إدارة الأزمات والظروف الاستثنائية من وجهة نظر القيادات الإشرافية لدى مصلحة مياه بلديات الساحل بمحافظات قطاع غزة
Authors: أبو مصطفى محمد مصطفى , الرقب حماد محمود
Published: April 2024

هدفت الدراسة إلى التعرّف على دور استراتيجية التمكين الاداري في إدارة الأزمات والظروف الاستثنائية كدراسة مسحية على القيادات الإشرافية لدى مصلحة مياه بلديات الساحل بمحافظات قطاع غزة" واستخدمت الدراسة المنهج الوصفي التحليلي، والاستبانة أداةً لجمع البيانات؛ وللإجابة على تساؤلاتها واقتصر الباحثان في الدراسة على المناصب الإشرافية والمكونة من (30) مفردة وقد توصّلت الدراسة إلى جملة من النتائج كان أهمها أن  هناك موافقة كبيرة من مفردات عينة الدراسة حول دور استراتيجية التمكين الإداري في إدارة الأزمات والظروف الاستثنائية لدى المؤسسة، حيث بلغ المتوسط الحسابي العام لجميع محاور الاستبانة ما قيميته (3.91)،وكانت النتائج بترتيب الأولويات التي حققت استراتيجية التمكين الإداري كالتالي: (التفويض، المشاركة في اتخاذ القرار، التدريب، تحفيز العاملين، والاتصال الفعال). وأوصت الدراسة مجموعة من التوصيات أبرزها: يجب على الإدارة العليا منح العاملين استقلالية  أكبر للعمل خلال فترة الأزمات والظروف الاستثنائية، ومنح السلطات الكافية للعاملين للتغلب على الأزمات والظروف الاستثنائية.
Pengaruh Aktivitas Budaya Keramba Jaring Apung Terhadap Kualitas Air Sungai Mempawah
Authors: Sinurat Merry Ananda Pratiwi , Utomo Kiki Prio , Desmaiani Herda
Published: April 2024

The Mempawah River is a water source used by the people of Mempawah Regency and plays an important role in supporting life. One of the community activities as a means of livelihood is fishing activities, namely fish cultivation. Effluent or waste from cultivation activities goes directly into the river body. This causes the entry of polluted materials such as organic materials originating from feed remains, feces and fish urine into the river body and can affect river water quality parameters. Increasing the concentration of organic matter in water can have an impact on reducing water quality. One of them is increasing BOD concentration. This research aims to determine the BOD concentration in waters, calculate the pollution load. The results of the research show that there is a BOD concentration value that is above the class II river water quality standard according to Government Regulation Number 22 of 2021.
Application of speed and agility training: How do they affect dribbling skills in football?
Authors: Chafidz Reyhan , Juli Candra , ‘Ala Faridatul , Troyanovska Mariya
Published: April 2024

Background and Study Aim. Dribbling skills have a crucial role in the achievement of a football player, especially at a young age level such as the SSB Medan Satria U-16 Football team. This study aims to investigate the effect of speed and agility on the dribbling skills of SSB U-16 Medan Satria students.Material and Methods. The method used in this research is experimental, the data collection techniques used are tests and measurements. The population in this study were SSB U-16 Medan Satria students. The sample taken from the results of purposive sampling amounted to 20 students. The instrument used is a dribbling skill test. Data analysis using the SPSS 26 application.Results. The results showed a significance value of 0.000 <0.05 so there is a significant effect of speed training on dribbling skills of soccer games. The application of agility training shows a significance value of 0.000 <0.05 so that there is a significant effect of agility training on dribbling skills of soccer games. Further results show the comparison between speed training and agility training shows a significance value of 0.000 <0.05 which means that there is a significant difference between speed training and agility training, the results also provide information that speed training is better for improving dribbling skills.Conclusions.The results of this study are expected to provide a clear picture of the effect of speed and agility training on dribbling skills at the youth level. These findings can then be applied in the development of a more specific and focused training program, with the aim of improving the quality of each player's dribbling skills.
Impact of Pocari and Mineral drinks on pulse rate after running 1200 meters with a 5-minute rest interval
Authors: Gunawan Dede , Custodio Joselito M. , Suniga John Paul C. , Laoan Menard Ian , Stojmenović Dragutin
Published: April 2024

Background and Study Aim. Electrolyte drinks are ion replacement drinks in the body that also help as additional energy.  Moreover, it is said that this drink is not a drug because it has not been clinically tested so that it is included in the list and also complementary drinks have benefits and side effects for its users, of course, supplement drinks that isotonic drinks affect dehydration and isotonic drinks can normalize body fluids that have been lost during exercise. The purpose of this study was to determine the difference in the usefulness of Pocari and Mineral for fluids in the body after prolonged exercise.Material and Methods. This research is an experimental method. The population in this study were Tanjungpura University Sports Students Semester 5 with a total of 18 people divided into 2 groups so each group contained 9 people. In this study, the sample was given physical activity treatment through running 1200 meters. Furthermore, Pcoari and Mineral drinks were given to see the effect on pulse rate. Data analysis was assisted using SPSS 26.Results. The results show a significance value of 0.173 > 0.05 so it can be concluded that the data results of pocari water and mineral water do not experience significant differences. These results provide information that provides the same impact on pulse rate after physical activity. However, the mean value results show that mineral water (162.56) is smaller than pocari drinks (175.00).Conclusions. This result has important implications, especially for athletes or individuals engaged in similar sports activities. Consumption of mineral-containing isotonic drinks may be an effective strategy in supporting the body's recovery after physical exercise, thereby improving overall sports performance.
The balance before and after dehydration: an experiment to see the difference
Authors: Purnomo Muhammad Iqbal , Roldan Patrick John B. , Cabarles John Paul A. , Quinto Janna Marie B. , Garcia-Jimenez Jose Vicente
Published: April 2024

Background and Study Aim. Balance is the ability to maintain the position of the body when standing, doing activities, also useful equilibrium, posture in order to be able to perform movement activities properly, water is very important for humans which is useful for maintaining cell hemostasis, fluid management interventions that pay attention to intek and output records that te Physical activity is a movement that involves muscles and energy working harder. This study aims to determine the difference in the effect before and after dehydration on body balance.Material and Methods. This research is a descriptive experiment. This research was conducted at the Sultan Syarif Abdurahman stadium field, Pontoianak City. The population used Sports Coaching Education students. Purposive sampling technique so that 16 students were sampled. The treatment was in the form of running 400m x 5 with a percentage of dehydration of 2%. Furthermore, the data were analyzed using SPSS 26.Results. The results showed a significance value of 0.241> 0.05, it can be concluded that there is no significant difference before and after dehydration on body balance. However, the calculation results can be seen that the mean balance will decrease if the body is dehydrated.Conclusions. Although there is a variation in the mean value, the difference does not reach the level of statistical significance. Thus, it can be concluded that body balance is not significantly affected by fluid loss before and after dehydration.
Tailoring Phosphine Ligands for Improved C-H Activation: Insights from Δ-Machine Learning
Authors: Huang Tianbai , Geitner Robert , Croy Alexander , Gräfe Stefanie
Published: April 2024

Transition metal complexes have played crucial roles in various homogeneous catalytic processes due to their exceptional versatility. This adaptability stems not only from the central metal ions but also from the vast array of choices of the ligand spheres, which form an enormously large chemical space. For example, Rh complexes, with a well-designed ligand sphere, are known to be efficient in catalyzing the C-H activation process in alkanes. To investigate the structure-property relation of the Rh complex and identify the optimal ligand that minimizes the calculated reaction energy ΔE of an alkane C-H activation, we have applied a Δ-Machine Learning method trained on various features to study 1,743 pairs of reactants (Rh(PLP)(Cl)(CO)) and intermediates (Rh(PLP)(Cl)(CO)(H)(propyl)). Our findings demonstrate that the models exhibit robust predictive performance when trained on features derived from electron density (R2 = 0.816), and SOAPs (R2 = 0.819), a set of position-based descriptors. Leveraging the model trained on xTB-SOAPs that only depend on the xTB-equilibrium structures, we propose an efficient and accurate screening procedure to explore the extensive chemical space of bisphosphine ligands. By applying this screening procedure, we identify ten newly selected reactant-intermediate pairs with an average ΔE of 33.2 kJ mol-1, remarkably lower than the average ΔE of the original data set of 68.0 kJ mol-1. This underscores the efficacy of our screening procedure in pinpointing structures with significantly lower energy levels.
Towards enhancing wastewater treatment in Integrated Assessment and Computable General Equilibrium models
Authors: Dunn Jennifer , Green Kristen , Vasquez-Arroyo Eveline , Awais Muhammad , Gomez-Sanabria Adriana , Kyle Page , Palatnik Ruslana , Schaeffer Roberto , Zhou Pengxiao , Aissaoui Baya , De Cian Enrica
Published: April 2024

Sustainable water management is essential to increase water availability and decrease pollution in surface and ground water. The expanding wastewater sector plays a pivotal and growing role in managing wastewater globally. Furthermore, technology in use at wastewater treatment plants is evolving to recover nutrients, which increases energy consumption. This technology, however, may reduce demand to produce nutrients from virgin sources. To capture these trends in the wastewater sector and its interlinkages with the fertilizer and agricultural sectors, it is essential for integrated assessment and computable general equilibrium models that address the energy-water nexus to evolve. We estimate how much energy consumption (1,100 million GJ) and greenhouse gas emissions (84 million t CO2e) may increase globally until 2030. We also estimate that the share of national fertilizer demand that could be recovered from wastewater could be nearly 100% for some African nations, but is much lower for large, agriculturally dominant nations like China and the United States. We then review sixteen models integrated assessment and computable general equilibrium models to assess how well they capture wastewater treatment plant energy consumption and GHG emissions. Only three models included biogas production from wastewater organic content. Four models explicitly included representations of energy demand for wastewater treatment, and eight models included explicit representation of the greenhouse gas emissions produced by wastewater treatment. Of the eight models including representation of greenhouse gas emissions from wastewater treatment, six models include representation of methane emissions from treatment, five models include representation of emissions of nitrous oxide, and two models include representation of emissions of carbon dioxide. Our review concludes with proposals to improve integrated assessment and computable general equilibrium models to better capture the energy-water nexus associated with the evolving wastewater treatment sector.
Exploring the polymorphism of dicalcium silicates using transfer learning enhanced machine learning atomic potentials
Authors: López-Zorrilla Jon , Aretxabaleta Xabier M. , Manzano Hegoi
Published: April 2024

Belitic cements are a greener alternative to Ordinary Portland Cements due to the lower CO2 associated to their production. However, their low reactivity with water is currently a drawback, resulting in longer setting times. In this study, we utilize a combination of evolutionary algorithms and machine learning atomic potentials (MLPs) to identify previously unreported belite polymorphs that may exhibit higher hydraulic reactivity than the known phases. To address the high computational demand of this methodology, we propose a novel transfer learning approach for generating MLPs. First, the models are pre-trained on a large set of classical data (ReaxFF) and then re-trained with Density Functional Theory (DFT) data. We demonstrate that the transfer learning enhanced potentials exhibit higher accuracy, require less training data, and are more transferable than those trained exclusively on DFT data. The generated machine learning potential enables a fast, exhaustive, and reliable exploration of the dicalcium silicate polymorphs. This includes studying their stability through phonon analysis and calculating their structural and elastic properties. Overall, we identify ten new belite polymorphs within the energy range of the existing ones, including a layered phase with potentially high reactivity.
Chlorophyll Binding to Poly(cysteine methacrylate) Scaffolds in Pigment-Polymer Antenna Complexes studied by Depth-Profiling X-Ray Photoelectron Spectroscopy with a Gas Cluster Ion Source
Authors: Csanyi Evelin , Hammond Deborah , Bower Benjamin , Johnson Edwin , Lishchuk Anna , Armes Steven , Dong Zhaogang , Leggett Graham
Published: April 2024

X-ray photoelectron spectroscopy (XPS) depth-profiling with an argon gas cluster ion source (GCIS) was used to characterize the spatial distribution of chlorophyll a (Chl) within a poly(cysteine methacrylate) (PCysMA) brush grown by surface-initiated atom-transfer radical polymerization (ATRP) from a planar surface. The organization of Chl is controlled by adjusting the brush grafting density and polymerization time. For dense brushes, the C, N, S elemental composition remains constant throughout the 36 nm brush layer until the underlying gold substrate is approached. However, for either reduced density brushes (mean thickness 20 nm) or mushrooms grown with reduced grafting densities (mean thickness 6-9 nm), elemental intensities decrease continuously throughout the brush layer, because photoelectrons are less strongly attenuated for such systems. For all brushes, the fraction of positively charged nitrogen atoms (N+/N0) decreases with increasing depth. Chl binding causes a marked reduction in N+/N0 within the brushes and yields a new feature at 398.1 eV in the N1s spectrum assigned to tetrapyrrole ring nitrogen atoms coordinated to Zn2+. For all grafting densities, the N/S ratio remains approximately constant as a function of brush depth, which indicates a uniform distribution of Chl throughout the brush layer. However, a larger fraction of repeat units bound to Chl is observed at lower grafting densities, reflecting a progressive reduction in steric congestion that enables more uniform distribution of the bulky Chl units throughout the brush layer. In summary, XPS depth-profiling using a GCIS is a powerful tool for characterization of these complex materials.
Use of Leishmania-Derived Extracellular Vesicles as a Vaccine Platform Against Emerging Viral Diseases
Authors: Cai Susan
Published: April 2024

Extracellular vesicles (EVs) are small membrane-bound “vehicles” responsible for transporting biological materials from source cells to target cells. EVs are thus indirectly capable of inducing changes in the physiological state and behavior of target cells once their contents are successfully released or received. Both prokaryotic and eukaryotic species utilize EVs for a variety of purposes. For example, Leishmania, a protozoan parasite, has demonstrated the ability to secrete immunomodulatory EVs. Various studies have shown that it is not these EVs in themselves, but rather the contents of these EVs that are directly involved in the parasite’s colonization and replication inside host cells. Although using Leishmania as an expression system for recombinant proteins has been explored (investigations have yielded successful and promising results), the use of Leishmania-derived EVs is a burgeoning field of research. In fact, considering extant research on EV-based vaccines, substantial potential lies in exploiting Leishmania-derived EVs as a novel vaccine platform. Hence, this study aims to discuss the immunomodulatory capabilities of Leishmania-derived EVs and their potential application in vaccine development. Lastly, in piecing together the nature of Leishmania-derived EVs and the general therapeutic potential of engineered EVs, it is further hypothesized that Leishmania may be an effective expression system for EVs that harbour desired viral antigens as a part of more efficient vaccine designs.
ẢNH HƯỞNG CỦA THAN TRẤU VÀ THAN TRE ĐẾN SỰ PHÁT THẢI KHÍ CH4 VÀ N2O TỪ ĐẤT PHÙ SA TRONG ĐIỀU KIỆN PHÒNG THÍ NGHIỆM
Authors: Hồ Vũ Khanh
Published: April 2024

Sử dụng biochar là một giải pháp tiềm năng để giảm phát thải khí nhà kính. Nghiên cứu được thực hiện nhằm đánh giá và so sánh hiệu quả của than trấu và than tre để giảm phát thải CH4 và N2O trên đất lúa trong hai điều kiện: ngập nước liên tục và ngập khô xen kẽ. Nghiên cứu gồm hai thí nghiệm: (i) đất phù sa trồng lúa ngập nước hoàn toàn; (ii) đất phù sa trồng lúa có ẩm độ 90%. Mỗi thí nghiệm được bố trí gồm bảy nghiệm thức với hai loại than (i) than trấu và (ii) than tre với ba mức than bổ sung 0,1, 0,2 và 0,5% và đối chứng (không bón than). Trong điều kiện ngập nước liên tục, phát thải CH4 là quá trình phát thải chính và ngược lại trong điều kiện đất có ẩm độ 90% thì N2O phát thải chính. Bón than trấu với tỷ lệ 0,2 và 0,5% cho hiệu quả giảm phát thải CH4 27,66–45,19% so với đối chứng (p < 0,05). Bón than trấu giúp giảm tổng lượng phát thải N2O 5,9–9,6 lần và bón than tre giảm 4,1–5,9 lần so với đối chứng (p < 0,05). Bón than trấu với mức 0,5% cho hiệu quả giảm phát thải khí nhà kính CO2eq tốt nhất, thấp hơn 8,9 lần so với đối chứng và thấp hơn 50,3% so với than tre trong cùng tỷ lệ.
TIỀM NĂNG TÀI NGUYÊN NƯỚC KHU VỰC CHÀNG RIỆC, TỈNH TÂY NINH VÀ GIẢI PHÁP KHAI THÁC, SỬ DỤNG TIẾT KIỆM NƯỚC
Authors: Phan Chu Nam , Nguyễn Tiến Tùng , Nguyễn Văn Tài , Nguyễn Uy Vũ , Nguyễn Trung Kiên
Published: April 2024

Khu dân cư ấp Chàng Riệc, xã Tân Lập, huyện Tân Biên, tỉnh Tây Ninh, được xây dựng ở gần biên giới giáp với Campuchia. Với vị trí đặc thù ở khu biên giới, nằm cách trung tâm xã Tân Lập 30 km, ấp Chàng Riệc rất cần nguồn nước ngầm để phục vụ cho nhân dân của ấp. Các phương pháp khảo sát khác nhau như: khảo sát các lộ trình theo tuyến, công tác khoan thăm dò và đo địa vật lý, tính toán bằng phương pháp cân bằng và phương pháp thuỷ động lực được thực hiện nhằm đánh giá tiềm năng tài nguyên nước của khu vực. Kết quả điều tra và tính toán cho thấy lưu lượng dòng chảy nước mặt nhỏ, mực nước thấp và thường cạn kiệt vào mùa khô. Tổng tiềm năng nước dưới đất ở khu vực nghiên cứu là 224.151 m3/ngày và trữ lượng có thể khai thác nước dưới đất trong vùng là 67.245 m3/ngày. Tuy nhiên, để đưa vào khai thác lâu dài và đảm bảo hiệu suất của các lỗ khoan khai thác, lưu lượng khai thác lớn nhất được đề xuất bằng 75% lưu lượng khai thác dự báo của các lỗ khoan.
Application of Daivavyapashraya chikitsa in Charakasamhita
Authors: V Veena P , Anusha Baburaj , S M Vaidya
Published: April 2024

Health is considered as the state of complete physical mental social and spiritual wellbeing of an individual and not merely the absence of disease or infirmity. This concept can be related to the definition of health as described by Susruta which also gives importance to the above said elements in a way by the involvement of a proper digestive capacity happy soul senses and mind. As we look globally nearly 450 million people suffer from a psychological or behavioral disorder. Among them as many as 1 million people commit suicide every year as per WHO World Health Organization. In this area of specification Ayurveda can provide better treatment modality in controlling or curing them through various treatment modalities. Daivavyapasraya divine therapy is a unique non-pharmacological approach for treating the somatic as well as psychological disorders. Hence exploring the concepts of divine therapies explained in classical treatises will enhance and add on to the existing knowledge and also aids in clinical aspects of treatment.nbsp
Assessment of Lifestyle changes among Information Technology Professionals during COVID-19 using a Multidimensional Scale: A Cross-Sectional Study
Authors: T S Ranganath , Pawar Pratap , Dsouza Neha , Selvest Geethu , M S Hema , Saral Rinisha , L Sanadi Shweta , P M Nasreen
Published: April 2024

Background Lifestyle plays an important role in pathogenesis of several non-communicable diseases and healthy lifestyle habits are vital for maintaining an individualrsquos physical and mental health. The rapid spread of the COVID-19 virus to nearly all parts of the country has posed an enormous health economic environmental and social challenges. This study evaluates whether lifestyle behaviours have changed among IT professional under home isolation during COVID-19 pandemic.Objectives To assess the lifestyle habits among IT professionals during COVID-19 pandemic and to determine the factors associated with lifestyle changes among IT professionals during COVID-19 pandemic.Methodology A cross-sectional study was done using online survey among 75 IT Professionals. A semistructured questionnaire was used to collect socio-demographic details and a validated schedule called SMILE Short Multidimensional Inventory Lifestyle Evaluation was used to assess lifestyle habits under the domains of diet and nutrition substance use physical activity stress management sleep social support environment exposure screen timeoutdoor time.Results The Mean SMILE score among the participants was 127.2 plusmn 16.8. Significant association was seen between physical activity stress management and gender. Marital status and lifestyle habits also showed significant association. Significant association was also seen between being diagnosed with COVID-19 and substance use.Conclusion In this study participants reported changes in lifestyle habits in different domains which are significantly associated with gender marital status positive for COVID-19 infection and self-isolation during the COVID-19 pandemic. These findings can help to device lifestyle guidelines among IT professionals during any public health emergency in the future.
Computational Biology: Research and Applications
Authors: M Dr. Santhoshkumar
Published: April 2024

We can use computational biology to analyze massive volumes of biological data and identify complicated patterns and relationships. Researchers can acquire insights into fundamental biological processes such as gene regulation, protein folding, and cellular signaling by using computer models and algorithms. This information is critical for furthering our understanding of biological systems. Computational biology is essential for speeding up the drug discovery and development process. Computational biologists can uncover promising drug candidates, forecast efficacy, and optimize their properties by modelling drug-target molecule interactions. This method decreases the time, money, and resources needed for standard experimental drug screening, allowing for the faster discovery of new medicines.
Effectiveness of Adas Leaf Infusion (Foeniculum vulgare L.) in Post-Best White Rats (Rattus Sp.) On The Growth Of Children
Authors: Yana Dwi Yovi
Published: April 2024

Adas leaf (Foeniculum vulgare L.) was known by the people around the mountain sides of Merbabu as one type of vegetable to increase breast milk secretion. Increased breast milk secretion has positive effect on pups development in early period of life. The aim of this study is to determine the effect of infusion of adas leaves, the effective dose of infusion against the growth of body weight and body length of pups and the levels of flavonoids, steroids, and stigmasterol on adas leaf. The study was conducted using 12 post-partum rats that have each 5 pups. White rats were divided into 4 groups: control group; the G1 (20 grams/300 ml dose infusion); the G2 (40 grams/300 ml dose infusion); and G3 (60 grams/300 ml dose infusion). Each group consisted of three replications. All of rats mother treated with the adas leaves by infuse feeding (sonde). Adas leaves was infused by 1 ml for 2 times a day on the rats mother (morning and evening). Rats mother were given pellets and also drinking water by adlibitum. Both mother and inbred rats were weighed, length of its body weight was measured every 5 days for 15 days. Data were analyzed by Analysis of Variance (ANOVA) two way and continued by Duncan Multiple Range Test (DMRT). Quantitatively measurements of total flavonoids, steroids and stigmasterol of adas leaves analyzed using Thin Layer Chromatography (TLC). The results showed that infusion of adas leaves significant difference in the growth of body weight and body length between control and treatment groups (p < 0.05). A dose of 60 grams/300 ml of distilled water can effectively increase the growth of body weight and body length of pups. Levels of total flavonoids, steroids and stigmasterol of adas leaves, respectively, are 0.43 %, 0.029 %, and < 0.011 %.