bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of Osteogenic and Angiogenic Markers in Alkali-Treated Titanium for Hard Tissue Engineering Applications
Authors: Chowdhury Prantik Roy , Kling Dexter , Markiewicz Michael R. , Bothwell Paige , Vahabzadeh Sahar
Published: September 2024

Titanium (Ti) and Ti alloys are of great interest in bone and dental tissue engineering applications due to their biocompatibility, corrosion resistance, and close mechanical properties to natural bone. However, the formation of fibrous tissue prevents osteointegration and results in implant loosening. Thus, physical and chemical methods are used to improve the surface properties of Ti. This study aimed to understand the role of alkali treatment conditions, including alkali medium concentration, temperature, rotation speed, and post heat treatment. Our results show that alkali treatment using 5 and 10 molar sodium hydroxide (NaOH) solution allows the formation of web-like microstructure. However, a higher concentration of 15 molar resulted in cracks along the surface. Interaction between the human fetal osteoblast cells and Ti samples showed that heat treatment is necessary for increased cellular proliferation, which was not significantly different at later time points compared with the polished Ti. Alkali heat treatment did not induce inflammatory reactions at later time points. It showed an increase in vascular endothelial growth factor, osteoprotegerin/nuclear factor kappa-Β ligand ratio, and osteocalcin expression, which is evidence for accelerated osteoblast cell maturation and bone remodeling in surface-modified samples. Together, these data show that alkali treatment using 5 or 10 molar of NaOH followed by heat treatment may have a therapeutic effect and assist with bone tissue integration with Ti implant.
La Confianza de los Colombianos en la Gestión Política del Recurso Público como indicador de un ambiente democrático
Authors: Gómez Betancur Milany , Gómez Ramírez Sara , Tibaquira Castrillon Elizabeth
Published: September 2024

El presente trabajo tiene como objetivo analizar hasta qué punto confían los colombianos en el uso del recurso público y si esto tiene relación con la percepción que tienen del ambiente democrático en el país. Dicha investigación hace parte del macroproyecto titulado “Percepciones sobre la democracia y confianza política en Colombia 2022” que buscó analizar diversas actitudes, percepciones y practicas ciudadanas que influyen en la construcción o no de un ambiente democrático en Colombia.  Así, para lograr el objetivo del presente trabajo,  se usó una metodología mixta donde se hizo en primera instancia un análisis documental que posibilitara determinar qué se entiende por ambiente democrático y por un correcto manejo del recurso público, posteriormente, se  aplicó un instrumento demoscópico en las principales ciudades de Colombia (Bogotá, Medellín, Barranquilla, Cali, Bucaramanga) con un número total de 1000 muestras que luego fueron sistematizas y analizadas a través de un análisis de asociación de variables y correlacional, usando estadísticos como el chi-cudrado, la prueba de Person y el t de Studen.   El resultado estadístico indicó no solo que hay una baja confianza de los colombianos en el manejo de los recursos públicos, las instituciones y los líderes que los ejecutan y ordenan el gasto, sino que esto influye realmente en la percepción negativa que tiene del sistema democrático y, por ende, en la garantía de los derechos humanos el cual es la finalidad de un Estado con este sistema. Este tipo de investigaciones hacen un llamado desde la empírica a comprender el fenómeno de la corrupción, y su preocupante implicación para la democracia de la región, es ahí donde radica su originalidad.
A Study on the Morphometric Measurement and Intrinsic Innervation of the Knee Meniscus in Adult Burmese Population
Authors:   Associate Professor, Department of Anatomy, SEGi University, Kuala Lumpur, Malaysia., Than Thida , Roy Bedanta ,   Associate Professor, Department of Physiology, Quest International University, Malaysia., Lwin Soe ,   Associate Professor, Department of Gynaecology, Royal Colleague of medicine Perak (RCMP), Universiti Kuala Lumpur (Unikl), Malaysia., Nwe Tin Moe ,   Associate Professor, Department of Anatomy, Royal Colleague of medicine Perak (RCMP), Universiti Kuala Lumpur (Unikl), Malaysia., Yee Khin Than ,   Senior Lecturer, Department of Pharmacology, Preclinical	 Royal Colleague of medicine, Perak (RCMP), Universiti Kuala Lumpur (Unikl), Malaysia., Shin Mya Thein ,   Assistant Professor, Department of Anatomy, Faculty of Medicine & Health Sciences, UCSI University, Spring Hill Campus, Malaysia., Dar Hlaing Thaw ,   Senior Lecturer, Faculty of Medicine and Health, International Medical University (IMU), Malaysia.
Published: September 2024

Introduction: Understanding the dimensions of the knee joint menisci is crucial for arthroscopic surgery and the management of injuries. Menisci's size, shape, and composition play roles in determining the structural and material properties of the tissue allograft. The present study aims to describe the morphometric measurement and intrinsic innervation of the knee meniscus in Myanmar's adult population. Methods: The length, width, thickness, and other morphometric factors of 160 menisci from twenty male and twenty female autopsy bodies were measured. Five menisci from fresh cadavers were dissected, stained with Marsland, Glees, and Erikson’s staining methods, and examined under a light microscope. Results: The average length of the medial and lateral meniscus was 8.49 cm and 7.98 cm, respectively. The average width of the anterior horn, body, and posterior horn of medial menisci were 0.64 cm, 0.63 cm, and 1.25 cm, and that of lateral menisci were 0.94 cm, 0.89 cm, and 0.95 cm. The average thickness of the anterior horn, body, and posterior horn of medial menisci was 0.38 cm, 0.45 cm, and 0.47 cm, and that of lateral menisci were 0.25 cm, 0.42 cm, and 0.39 cm. Ruffini’s corpuscles, Paccinian corpuscles, and Golgi tendon organs with fibrous capsules were observed under the light microscope at the anterior and posterior horns of the menisci. Conclusions: The present study provides a good understanding of the knee meniscus in the Myanmar adult population, which will help morphologists and orthopaedic surgeons design prostheses and perform knee joint arthroscopy with a high success rate. KEYWORDS: Measurements, innervation, human, knee meniscus
Is Low Lying Pubic Tubercle A Risk Factor for Inguinal Hernia?
Authors:   Assistant Professor, Department of General Surgery, Kasturba Medical College, Mangalore, Manipal academy of higher education, Manipal, Karnataka, India., C. A Deepika , Harish Rao K  ,   Professor, Department of General Surgery, Kasturba Medical College, Mangalore, Manipal academy of higher education, Manipal, Karnataka, India.
Published: September 2024

Introduction: Inguinal hernia is the most common clinical entity which one comes across in surgical practice. According to recent research, the anatomical structure of the inguinal region is crucial for the development of hernias. Variations in the position of the pubic tubercle, especially a low-lying pubic tubercle, may alter the tension and integrity of the inguinal canal, potentially facilitating the development of hernias. This study compares the pubic tubercle locations in people with and without inguinal hernias by a thorough investigation of patient anatomical data and, to find any statistically significant associations which may help guide clinical practice and advance our knowledge of the pathophysiology of inguinal hernias. Methods: A hospital-based case control study carried out from October 2018 to October 2022 for a period of 24 months. 70 individuals who met inclusion criteria were selected for each group. In supine position of patient, the measurements of the perpendicular distance between the inter-spinal line and the pubic tubercle (PT line) and the distance between two anterior superior iliac spines (AA line) were taken and evaluated in all patients along with height, weight, BMI and pelvic circumference. The PT distance of 7cm and more was considered as low lying pubic tubercle. Results: Right sided inguinal hernia was found in 47.2 % of the cases. And most of them were indirect inguinal hernia (71.4%). Among the patients with hernia, the mean PT line distance was found significantly greater (7.807+/- 1.143) compared to the control group (6.60+/- 0.7846) with p value <0.0001. In our study, 71.4 % of patients with hernia had PT line >7 cm whereas in 81.4% of controls, the PT line was under 7 cm. Conclusion: Pubic tubercle being low i.e. more than 7 cm of PT line could be the risk factor for development of inguinal hernia owing to the widening of Hasselbach’s triangle along with the alteration in the internal oblique muscle insertion resulting in less effective shutter mechanism. KEY WORDS: Anterior superior iliac spine, Anthropological measurements Inguinal hernia, Low lying pubic tubercle, Risk factors.
Usage of Newer Immunotherapies in Myasthenic Crisis – A Review of the Literature
Authors: Li Yuebing , Dang Johnny , Uysal Sanem
Published: September 2024

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ПРОБЛЕМА «ЦИФРОВОЙ ОТМЕНЫ» ГРАЖДАН РОССИИ
Authors: ДИСКИН Евгений Иосифович
Published: September 2024

Рассмотрен феномен «цифровой отмены» как формы дискриминации на примере нарушения прав граждан России путем скоординированного и синхронного прекращения оказания цифровых информационных услуг и сервисов со стороны иностранных компаний и цифровых сервисов, а также установления прямого запрета на доступ к таким услугам и сервисам. Многочисленные примеры массовых запретов и ограничений, которые введены в отношении граждан России в  интернете на уровне социальных сетей, финансовых сервисов, сервисов доступа к онлайн-играм, программному обеспечению, сервисам для работы с искусственным интеллектом, позволяют сделать вывод, что такие действия являются дискриминацией и нарушением прав человека на свободный доступ к получению, сбору и распространению информации. Предлагается рассматривать такие действия в рамках международно-правовых документов, запрещающих дискриминацию по национальному признаку, в том числе в целях обращения в международные судебные органы с соответствующими судебными исками, которые могут быть поданы Российской Федерацией.
Reproductive Risk of Couples with Reciprocal Translocations
Authors: Dhurata Kolgeci , Jehona Kolgeci Istogu , Labinot Istogu , Nazmi Kolgeci , Christina Kouskouti , Besar Krasniqi , Diturije Kolgeci Krasniqi
Published: September 2024

Background: In carriers of reciprocal translocations, gametes with unbalanced chromosomes can be created during the reproductive period, which reduces the reproductive ability of the carriers. The reproductive risk of carriers of reciprocal translocations depends on the length of the translocation segment. The aim of this study was to evaluate the reproductive risk of reciprocal translocations with segments of different lengths for couples carrying these translocations. Methods: Chromosome analysis was performed using the Moorhead and Seabright method. For the exact identification of chromosomes, the standard method of G bands was used. Results: A cytogenetic diagnosis of reciprocal translocations with segments of different lengths was confirmed on 20 couples. Among the examined cases the most frequent (55%) were those with reciprocal translocations having a long translocated segment on one chromosome and a short translocated segment on another non-homologous chromosome. In total 64 pregnancies were conceived among the examined couples with reciprocal translocation. These pregnancies showed a higher risk of miscarriages and congenital anomalies: 59.4% resulted in recurrent miscarriages, 14.1% in stillborn babies, 10.9% in babies with congenital malformations, and 15.6% in normal birth. All three groups of subjects with different types of reciprocal translocations had a high risk for recurrent miscarriages. The three couples with reciprocal translocations had primary infertility. Conclusion: In our study population reciprocal translocations were identified as the main cause of impaired reproductive health in 17 couples and the primary cause of infertility in 3 couples. Among couples with reciprocal translocations involving long and short translocated segments, a higher risk of congenital anomalies and recurrent miscarriages was observed.
Analysis of the different winning strokes in professional padel: male vs. Female
Authors: Pozo-Ayerbe Carlos , Escudero-Tena Adrián , Ibáñez Sergio J. , Mancha Triguero David
Published: September 2024

Padel is one of the most booming sports today, however, more documents are needed to analyze the performance indicators in top-level competitions. The general objective of this research was to analyze the performance indicators in top-level competitions according to sex. The sample consisted of twelve matches (six men's and six women's) from the final rounds of different World Padel Tour tournaments in 2021, with a total of 1451 number of points. Variables related to the achievement of the point (Type of winning shot, Type of shot, Direction of the shot, Player, Area of the field) and to the dynamics of the game (Number of shots, Achievement of the point) were recorded. The results showed differences between the men's and women's matches, making percentage comparisons of the duration of the point and obtaining them, being able to observe how the game is slower in the women's matches and the variety of getting points is much greater than in the men's matches. Although in both modalities being close to the net is decisive, highlighting the shot, especially in the men's competitions, and the volleys, forehand and backhand, as the most used shots to achieve them. The serve will provide a significant advantage over the rest because they will be placed near the net.
Expression and purification of bacterial proteins (via N-terminal His-tag) v1
Authors: Dederer Verena , Mathea Sebastian
Published: September 2024

Recombinant protein production in bacteria provides an efficient system for obtaining high yields in a short time and at low cost. Although not every protein is suitable for expression in bacteria, it is usually the first choice to start expression trials. If successful, more elaborate protein purification protocols can be developed. Here we provide a two-step protocol for protein purification from bacterial cells.
Environmental DNA (eDNA) COI Metabarcoding PCR Protocol v1
Authors: Baker Jacoby , Pitz Kathleen
Published: September 2024

This protocol is aimed at amplifying the cytochrome c oxidase subunit I (COI) mitochondrial gene in eukaryotes. The primers (forward: mlCOIintF, reverse: HCO2198) utilized in this protocol are based on the primers utilized in Leray et al. 2013 (forward) and Folmer et al. 1994 (reverse). Primers used: Fluidigm CS1+mlCOIinfF, Fluidigm CS2+HCO2198 Amplicons generated using this protocol can then be sequenced using the Illumina platform. Primary PCR amplicon products are then sent to Michigan State University's (MSU) Research Technology Support Facility (RTSF) for indexing, pooling, and sequencing. This work was supported by NASA grant NNX14AP62A ‘National Marine Sanctuaries as Sentinel Sites for a Demonstration Marine Biodiversity Observation Network (MBON)’ funded under the National Ocean Partnership Program (NOPP RFP NOAA-NOS-IOOS-2014-2003803 in partnership between NOAA, BOEM, and NASA), and the U.S. Integrated Ocean Observing System (IOOS) Program Office.
EFL Teachers Perception of Formative Assessment – A Study of Vocational School (SMK) in Indonesia
Authors: Akter Mahmuda , Khan Muhammad Lookman Hossain
Published: September 2024

The formative assessment has become a core component in teaching. The educator uses it to measure the effectiveness of learning in the classroom, and it provides information on the competencies of the students in addition to enhancing learning outcomes for the students. This study aims to investigate the vocational school teachers' perception and practices of formative assessment in the EFL classroom. This study used a qualitative research design approach. Two experienced teachers from vocational schools in central java, Indonesia participated in this study. The author collected the data from the participants using a semi-structured interview and analysed the data using descriptive qualitative method. The study result revealed that the participants have a very good understanding of formative assessment. They believed that it allows them to become more professional and the classroom assessment help students to focus more on learning materials. The teachers implement formative assessment practices regularly in their classroom.
Techniques and Assessment of Entrepreneurial Skill Training Module for Building Technology Graduates of Colleges of Education
Authors: Ibidapo Abel Bamidele
Published: September 2024

The study was carried out to investigate the techniques and assessment of entrepreneurial skill training module for building technology graduates of colleges of education. Three research questions were answered while three null hypotheses formulated were tested at 0.05 level of significance. The study adopted research and development design and was carried out in South-west Nigeria. The population for the study was 373 subjects. There was no sampling because of the manageable size of the population. The instrument for data collection was structured questionnaire. Five experts face- validated the instrument. The internal consistency of the questionnaire items was determined using Cronbach alpha reliability method and the reliability coefficients of 0.81 was obtained for instructional strategies required for the implementation of entrepreneurial skill training module, and 0.79 for evaluation techniques for assessing activities of graduates of building technology while 0.88 was obtained as the overall reliability coefficient value for the entire questionnaire items. Kuder Richardson 20 (KR20) was used to determine the internal consistency of the BTET and coefficient value of 0.78 was obtained. Out of 373 copies of structured questionnaire administered, only 223 copies were completed representing 59.78 percent return rate. Mean was used for answering the research questions while analysis of variance and covariance were employed for testing the null hypotheses. The findings of the study also revealed that the following number of instructional strategies and evaluation techniques were considered for implementing the entrepreneurial skill training module: instructional strategies 20 and evaluation techniques 15. The hypotheses tested revealed that there was a significant difference in the mean scores of building technology graduates trained with the developed modules and those taught without training module. The study also recommended that instructional strategies and evaluation techniques identified should be used for implementing the entrepreneurial skill training modules.
Adaptation of Geomatics Engineering Teacher of Dual Expertise Program to New Skill Competencies
Authors: Yavis David , Herman Nanang Dalil
Published: September 2024

Research on eleven participants who work as teachers of the Geomatics Engineering Dual Expertise Program spread across various provinces throughout Indonesia has provided an in-depth desciption of the adaptation process they experienced to their new competency skills. The author conducts interviews with video calls through applications on sosial media by giving several questions to participants and also asking participants to tell about the adaptation process they have experienced so that the results obtained from this interview are more in-depth. The author processes the research data by transcribing the document, compressing the facts, then coding so that the conclusion is in the form of certain themes that can be grouped. From this research, the authors have succeeded in describing the main obstacles experienced by teachers in adapting and how they can overcome these obstacles in their way. This research shows that some of the obstacles for the geomatics engineering dual expertise program teacher in adapting to this skill competency are understanding new subject matter in the competency of geomatics engineering expertise, namely Geographic Information Systems (GIS) and Remote Sensing (RS) which are closely related to learning using software certainly. Inadequate facilities and infrastructure such as practical equipment for teaching and learning activities, lack of support from senior teachers in schools. The participants tried to overcome the obstacles they experienced with the shocking reality because they avoided teaching difficult subjects (subjects in Grade XI and XII) or tried to gain knowledge with senior teachers in school, even though not all senior teachers can provide support due to limited understanding of new material.
Nexus between soft skills and technical vocational education and training graduate employability
Authors: Awodiji Omotayo Adewale , Magogodi Coleen
Published: September 2024

Soft skills are increasingly seen as being crucial for the modern workforce due to the rapid and pervasive digitalisation that has transformed the nature of employment. To work with new technologies and stay up with the rapid changes in technology, graduates require employability skills. Despite the growing demand there remains a shortage of employability skills, organisations frequently struggle to identify qualified candidates for digital jobs because workforces frequently lack the skills necessary to manage digital change. Soft skills became more important as the pace of world of work moved online. Meanwhile, the role of TVET in job creation cannot be over emphasised in the changing world. Thus, the study examined how soft skills can enhance TVET graduates’ employability. Study participants included 351 students from Botswana TVET schools. To better understand how soft skills relate to TVET graduates' employability, we used STATA software to establish the correlation between the two variables. The result indicated that soft skills promote TVET graduates' employability. Hence, all TVET administrators should keep up-to-date with this present model so that they can design policies that promote employability for TVET graduates.
Exploring the connection between adolescent identity and well-being in vocational scope
Authors: Nisa Khoirun
Published: September 2024

Adolescence is a significant period starting with mental, emotional development and physical development; adolescents experience many problems due to unfulfilled levels of welfare subject. Because the level of youth welfare also measures the progress of a country, a country also has a responsibility to improve the welfare of its youth. For this reason, this study aims to find which adolescent welfare domain subjects need more attention. Research on youth welfare uses the bibliometric analysis method with the help of the VOS Viewer application system using the keyword "Wellbeing for youth" using the limitations of the type of journal articles in English that have been published in the last five years and obtained as many as 840 data with 114 keyword verifications. Used to visualize bibliometric maps. The results of research that has been conducted from 114 keywords, mental health, which is one of the subject domains of welfare, is a keyword that is often researched in the last five years, and the country with the highest level of research on adolescent interest is the United States and in followed by the United Kingdom and followed by several other developed countries.
Asylum Seekers’ Trajectories of Exclusion: An Analysis Through the Lens of Intersectionality
Authors: Branco Ana Sofia , Xerez Romana
Published: September 2024

The recent increase in asylum seekers in Portugal has drawn attention to the need for effective social integration. The experiences of asylum seekers reveal the existence of social exclusion before migration and the need for them to be included to participate in host societies. This research employs a qualitative methodology, analysed through the lens of intersectionality. In 2021, twenty‐six semi‐structured interviews were conducted with asylum seekers, detailing their trajectories to Europe from their countries of origin in the Global South. The interviews explored their experiences and the reception they encountered in their final or intermediate destinations. The findings indicate that the departures from the countries of origin are associated with contexts of human rights violations—discrimination and persecution due to respondents’ religious, social, ethnic, or sexual orientation. The routes to Europe involved long and perilous journeys by land or sea facilitated by smugglers who charged exorbitant amounts without ensuring protection. The results also reveal that the exclusion asylum seekers experience continues even after requesting international protection in a European country. The findings of this empirical research are important because Portugal has been identified as a safe alternative for the secondary movements of asylum seekers. However, structural issues associated with a struggling welfare state push migrants into new contexts of social exclusion. Our analysis helps to identify trajectories of exclusion among new waves of asylum seekers with implications for decision‐makers and policy actors.
Pediatric follicular lymphoma: literature review and presentation of a rare clinical case
Authors: Volkova A. S. , Valiev T. T. , Abramov D. S. , Tarakanova A. V. , Odzharova A. A. , Ryabukhina Yu. E. , Zeynalova P. A.
Published: September 2024

Follicular lymphoma is one of the most common non-Hodgkin’s lymphomas in adults. One of the rather rare variants of follicular lymphoma is pediatric follicular lymphoma. This variant, despite the name, is diagnosed not only in children, but also among young adults. Pediatric follicular lymphoma is characterized by early (I, II) stages, the absence or weak BCL2 expression, and the predominant absence of t(14;18)(q32;q21) translocation. Treatment tactics vary widely from radical surgical tumor resection with subsequent follow-up to chemoimmunotherapy with rituximab.

This article presents a clinical case of advanced pediatric follicular lymphoma (stage III) in a 5-year-old patient. Using a combined treatment approach (surgery followed by immunochemotherapy) allowed to achieve a complete metabolic response which lasts more than a year.
Trisomy 14 as the only cytogenetic abnormality in myelodysplastic syndrome
Authors: Pautova M. N. , Koloskova L. E. , Filippova O. I. , Koloskov A. V.
Published: September 2024

Evaluation of bone marrow cytogenetic abnormalities in myelodysplastic syndrome is of great importance for confirming the clonal disease nature, determining the prognosis and choosing treatment tactics. Cytogenetic abnormalities are detected in 40–70 % of patients with myelodysplastic syndrome, and the variety of these abnormalities reflects the disease characteristics.

This article describes the clinical follow-up of a patient with a myelodysplastic neoplasia with blast excess 1 and trisomy of chromosome 14.
Clinical profile and therapeutic aspects of mycosis fungoides: a retrospective analysis of 210 cases in Russia
Authors: Gorenkova L. G. , Zvonkov E. E. , Mangasarova Ya. K. , Chabaeva Yu. A. , Kulikov S. M. , Kovrigina A. M. , Kuzmina L. A. , Sidorova Yu. V. , Mozdon M. A.
Published: September 2024

Background. Mycosis fungoides (MF) is classified as an orphan disease. Due to the rarity of pathology, and until recently the absence of an expert group and a specialized reference center for cutaneous lymphomas in Russia, possible treatment options for MF are presented by listing them without recommendations on the preferred indications for one or another option. This creates difficulties in choosing treatment methods and assessing their effectiveness.

Aim. To characterize current treatment methods and their results in MF patients who were observed or received consultative and diagnostic care at the National Medical Research Center for Hematology.

Materials and methods. The study included 210 patients: 115 with early disease stages and 95 with advanced stages.

Results and conclusion. The most common treatment options were for early stages – local therapy, interferon therapy and systemic chemotherapy (CT), for advanced stages – combination therapy with interferon (+ PUVA therapy, methotrexate), interferon monotherapy and systemic CT. The frequency of systemic chemotherapy use in all lines of MF treatment was 21 %. When integrating statistical analysis using the probability of achieving an antitumor response, switching to 2nd line therapy, and accumulated incidence, the negative results of using chemotherapy in the MF treatment were clearly demonstrated.

For the first time in Russia, a real practical situation of the applied MF treatment options is presented on our own large sample of patients. As the first line of therapy, the most common options were immunotherapy and phototherapy, however, in 12.4 % of cases, the use of systemic CT was registered, which is unjustified and leads to a decrease in the time to the next line of treatment and an increase in the cumulative incidence of adverse events. As a result of the use of non-chemotherapeutic approaches (interferon, etc.), the 3-year relapse-free survival rate is about 40 %, after chemotherapy – 9.4 %. Secondand third-line therapy provided more varied options, including combination treatment with interferon and methotrexate, as well as gemcitabine monotherapy, targeted therapy with brentuximab vedotin, and epigenetic therapy in the 3rd line. Studies with targeted agents in this patient population have demonstrated improved clinical outcomes, highlighting the need for their early use to achieve the best results.
Pain syndrome in multiple myeloma (results of a single-center study)
Authors: Soloveva M. V. , Solovev M. V. , Irugova E.  Z. , Startsev A. A. , Arutyunyan N. K. , Krayzman A. A. , Abakumova A. V. , Mendeleeva L. P.
Published: September 2024

Background. One of the most common symptoms of multiple myeloma (MM) is pain. Bone pain is observed in 60– 80 % of patients at the disease onset. Neuropathic pain syndrome is also often found in MM.

Aim. To characterize the pain syndrome in MM at the disease onset and various therapy stages.

Materials and methods. From January 2019 to October 2021 a retrospective single-center study included 105 patients with newly diagnosed symptomatic MM (49 men, 56 women) aged from 26 to 83 years (median 58.5). Induction therapy in all patients was performed with bortezomib-containing regimens. High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) was performed in 44 patients. The Fisher–Freeman test was used to analyze contingency tables.

Results. Pain syndrome of varying severity at the onset of MM was observed in 83 % of patients. The median time from the onset of pain to the diagnosis of MM was 120 days. In 62.5 % of patients with kidney damage and pain, analgesics (mainly nonsteroidal anti-inflammatory drugs) were used before the diagnosis of MM. In patients with pain syndrome, compared with patients without it, at the onset of MM, pathological fractures (p = 0.01), bone plasmacytomas (p = 0.0001), hypercalcemia (p = 0.03) were significantly more often detected, and stage III was diagnosed according to Durie– Salmon (p = 0.021). The incidence of peripheral toxic polyneuropathy was 35 %. Complete regression of polyneuropathy symptoms was observed in 19 % of patients, and a significant decrease – in another 62 % of cases. The main manifestation of pain syndrome during auto-HSCT was pain in the oral cavity due to mucositis of varying severity.

Conclusion. Our study showed that MM patients mainly with stage III (86 % of cases) are referred for hospitalization to the National Medical Research Center for Hematology. Moreover, in 83 % of them the disease is accompanied by severe pain. More than a third of patients (35 %) developed bortezomib-induced peripheral polyneuropathy. Opioid analgesics are used for pain relief in the hospital, the indications for which were recorded in 45 % and 41 % of patients with MM during induction therapy and auto-HSCT, respectively.
Immunological features of the bone marrow microenvironment and assessment of bone marrow lesions in patients with classical Hodgkin lymphoma
Authors: Melnikova A. A. , Abbasbeyli F. M. , Mushkarina T. Yu. , Vernyuk M. A. , Zeynalova P. A. , Grivtsova L. Yu. , Ivanov S. A. , Kaprin A. D.
Published: September 2024

Background. The study of bone marrow involvement is a necessary step in disease staging, both in non-Hodgkin lymphomas and in the case of Hodgkin lymphoma (HL). The standard assessment of bone marrow lesion is carried out based on immunohistochemical examination of bone marrow trepanobioptate, and recently computer technologies (positron emission tomography combined with computed tomography) have been introduced to assess bone marrow involvement. At the same time, immunological methods for detecting tumor cells using multicolor flow cytometry are more available. In addition, they allow for detailed study of the tumor bone marrow microenvironment.

Aim. To evaluate the immunomorphological features of bone marrow in HL and the possibility of identifying specific bone marrow lesions using flow cytometry.

Materials and methods. The study included the analysis of 107 bone marrow samples. The samples were obtained from 107 patients with various variants of classical HL, diagnosed and treated at the Lapino Clinical Hospital and the P.A. Herzen Moscow State Medical Institute from 2018 to 2022.

Results. The features of bone marrow lymphocytes subpopulation in patients with classical HL are shown.

Conclusion. An immunological assessment of bone marrow involvement degree was carried out, data from flow cytometry and immunohistochemical examination of trephine biopsy specimens during primary diagnosis were compared, and the features of bone marrow lymphocytes subpopulation were evaluated. The interrelation of these factors at the diagnostic stage in classical variants of HL was studied. At the end of treatment, the primary immunological data (the degree of bone marrow involvement) were compared with the results of the positron emission tomography combined with computed tomography.
From Apotheosis to Reverse Conversion: A Posthuman Reading of Euripides’ and Pasolini’s Medea
Authors: Barcaro Andrea
Published: September 2024

Medea is an ancient mythical figure who has caught the imagination of artists and authors across the centuries. In this essay, I focus on Euripides’ 5th-century BC eponymous tragedy and Pasolini’s 1969 cinematic adaptation. Through a posthuman reading of Medea, I propose that in Euripides the heroine sheds her humanity and embraces divinity in her final apotheosis. In Pasolini’s film, on the other hand, we witness a reverse conversion, a journey towards a loss of the sacred and a spiritual catastrophe. In my analysis, I explore how posthuman forms of subjectivity embrace monstrosity to emphasise the divine power of alterity. I propose that, by deactivating normative discourses and making possible resistance to norms, posthuman subjectivities can be a powerful tool to break the spell of the present and create productive alternatives to the seemingly timeless dominance of global capitalism.
The role of urogenital infection in the development of reproductive system disorders in minor children
Authors: Chebotareva Yulia Yu. , Petrov Yuri A.
Published: September 2024

BACKGROUND:Vaginitis and urinary tract infections are common diseases among minors suffering from reproductive system disorders.
AIM:To assess the state of vaginal microflora and features of neurohormonal status in adolescent patients with recurrent uro­genital inflammatory diseases.
MATERIAL AND METHODS:130teenage girls aged 16–18years were examined, the following groups were identified: first— 34patients with vaginitis and urinary tract infection; the second— 32patients with urinary tract infection, the third— 34patients with vaginitis without urinary tract infection, the fourth— 30teenage girls without vaginitis and urinary tract infection. An assessment of vaginal microbiota and individual parameters of neurohormonal status was carried out. The distribution of variables was checked for normality using the Kolmogorov–Smirnov test; for a normal distribution, the Student t-test; for anon-normal distribution, the Mann–Whitney U test. The significance of differences in relative values was assessed using Fisher and χ2tests. Results were considered statistically significant at p0.05.
RESULTS:It was found that in patients of the first group, in comparison with girls from other groups, there were fewer lactobacilli colonies (3.79±0.19genome equivalents/sample; p1–2=0.019, p1–3=0.012, p1–4=0.010), the relative indicator of biota was greater (0.81±0.12; p1–2=0.020; p1–3=0.011; p1–4=0.007). The growth ofCandida spp. colonies 103genome equivalents/sample was detected (82.4%; р1–2=0.021, р1–3=0.011, р1–4=0.002).There was an increase in the concentrations of cortisol (655.7±104.23nmol/l; р1–3=0.021, р1–4=0.024, р1–2=0.032), adrenaline (14.5±3.12nmol/l, р1–3=0.028, р1–4=0.030, р1–2=0.029), decrease in norepinephrine level (1.4±0.11nmol/l, р1–3=0.021, р1–4=0.023, р1–2=0.020), menstrual cycle disorders (85.3%; p1–2=0.024, p1–3=0.019).
CONCLUSION:In adolescent girls with recurrent urogenital inflammatory diseases, dysbiotic changes in the vaginal microflora, increased levels of stress hormones, and reproductive system disorders were revealed.
Reply to “Comment on ‘An Evaluation of the Timing Accuracy of Global and Regional Seismic Stations and Networks’ by Yang et al. (2021)” by Xin Zhang and Lianxing Wen
Authors: Yang Yi , Song Xiaodong , Ringler Adam T.
Published: September 2024

The finding of Yang et al. (2021; hereafter, YSR21) casts fundamental doubts on all the previous studies on the temporal changes of the inner core (IC) surface that are based on absolute arrival times, including Wen (2006; hereafter, WEN06) and its follow-up studies. The reports of small time shifts of the IC-reflected phase (PKiKP) likely misinterpreted station-related issues (clock errors and instrument changes) as evidence for rapid localized deformation at the IC surface. The comment by Zhang and Wen (2024; hereafter, ZW24) aims at defending the results and conclusions of WEN06 by questioning a tiny portion of the results (2 out of over 400 doublets and 3 out of over 400 problematic stations) in YSR21. In response, we acknowledge an accidental error in table S1 of YSR21, which is corrected in an erratum (Yang et al., 2023), although this does not affect the results or interpretations of YSR21. However, we strongly disagree with the criticisms in ZW24 due to many problems therein, especially the issue of irreproducibility due to its inconsistent procedures with YSR21. While the problems are related to the use of absolute arrivals in the previous studies by Wen’s group, key problems in this new comment are related to questionable data selection and inconsistent processing. We further caution the metadata updates, particularly when involving small temporal change signals. We focus on the main points in ZW24 and demonstrate that its arguments are problematic in many aspects and do not diminish the credibility of YSR21 or other related works by Yang and Song in support of the IC differential rotation.
A Revised Chilean Seismic Catalog from 1982 to Mid-2020
Authors: Potin Bertrand , Ruiz Sergio , Aden-Antoniow Florent , Madariaga Raúl , Barrientos Sergio
Published: September 2024

For more than two decades, Chile’s National Seismological Center has produced a seismic catalog built by manual reading of first-arrival P and S waves recorded by local and regional stations. This catalog helped improve the knowledge regarding the Chilean subduction zone and contains several important earthquake sequences. The density of stations, the kind of instruments, and the location criteria have evolved through time, preventing the earthquake catalog from being homogeneous. We analyzed the time and space variation of the seismicity and built a consolidated catalog of relocated events as a by-product of our research. Finally, we present the b-values, the completeness magnitude, and the most persistent clusters, which provide insights about the Chilean seismicity.
PENGGUNAAN MEDIA WORDWALL AIRPLANE GAME PADA MATERI INTERAKSI ANTARA KOMPONEN PENYUSUN SUATU EKOSISTEM UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS VII SMPN 8 MALANG
Authors: Dwi Resdiana Puput , Parno Parno , Al Fatih Solihin
Published: September 2024

Pendidikan memegang peranan penting dalam membentuk individu yang berwawasan luas. Dunia pendidikan tidak terlepas dari peran guru yang juga dituntut untuk terus belajar sepanjang hidupnya demi kemajuan dan keberhasilan pembelajaran. Pembelajaran yang berhasil tentunya menghadapi kendala-kendala yang perlu diatasi untuk mencapai tujuan pembelajaran. Salah satu permasalahan dalam dunia pendidikan adalah rendahnya motivasi belajar siswa. Pembelajaran IPA yang dirasakan sulit oleh sebagian siswa, mendorong dan menuntut guru untuk terus melakukan inovasi pembelajaran yang dapat menarik perhatian dan minat siswa dalam belajar. Media pembelajaran Wordwall Airplane Game merupakan salah satu bentuk media pembelajaran inovatif yang memanfaatkan teknologi untuk meningkatkan motivasi siswa. Diharapkan siswa lebih aktif terlibat dalam pembelajaran, lebih fokus, dan meningkatkan kemampuan memahami materi IPA khususnya pada topik interaksi antar komponen penyusun ekosistem. Metode yang digunakan dalam penelitian ini adalah penelitian pengembangan atau Research and Development (R&D) dengan menggunakan prosedur model pengembangan ADDIE yang terdiri dari lima tahap yaitu analisis, desain, pengembangan, implementasi, dan evaluasi. Hasilnya, motivasi belajar siswa meningkat dari rata-rata persentase 59,16 persen pada kategori sedang sebelum penerapan menjadi 93,75 persen pada kategori sangat tinggi, hal ini menunjukkan keberhasilan.
KESIAPAN LITERASI GENERASI DIGITAL NATIVES DALAM MENGHADAPI PENDIDIKAN ERA SOCIETY 5.0
Authors: Bayu Ambarsari Tri Agung
Published: September 2024

Pendidikan terus mengalami perkembangan seiring dengan perkembangan alam dan zaman. Pada era Society 5.0 manusia akan terus berkolaborasi dengan kemajuan teknologi dalam memenuhi kebutuhannya. Generasi yang berada di bangku sekolah merupakan generasi digital natives’ yang banyak menggunakan gadget dalam kegiatan sehari-harinya. Kebiasaan tersebut menjadi berpengaruh pada kualitas hidup setiap individu, memberikan pengaruh baik dan buruk. Untuk membendung dampak buruk dan meningkatkan kualitas hidup seseorang pada era ini diperlukan kemampuan literasi yang baik. Penelitian ini bertujuan untuk mengidentifikasi kesiapan literasi generasi digital natives dalam menghadapi pendidikan era society 5.0.  Metode yang digunakan dalam penelitian ini merupakan studi kepustakaan. Hasil dari penelitian ini menyatakan bahwa Indonesia harus segera mengambil langkah-langkah strategis untuk mempersiapkan pendidikan menghadapi Era Society 5.0. Upaya-upaya seperti peningkatan infrastruktur teknologi, penyesuaian kurikulum, dan pelatihan intensif bagi pendidik menjadi kunci untuk memperkuat literasi dalam pendidikan. Dengan demikian, Indonesia dapat mengoptimalkan potensi siswa dalam menghadapi tantangan dan peluang yang ditawarkan oleh transformasi digital ini, serta memastikan bahwa pendidikan menjadi pilar yang kuat dalam membangun masa depan yang berkelanjutan
ANALISIS PERBANDINGAN EFEKTIVITAS WAKTU DAN EFISIENSI BIAYA PELAKSANAAN PEKERJAAN DRAINASE BOX CULVERT PRECAST DAN CAST INSITU MENGGUNAKAN SOFTWARE PRIMAVERA P6 PADA PROYEK JALAN LINTAS SELATAN LOT 6 TULUNGAGUNG – TRENGGALEK
Authors: Agatha Shafa Adelia , Djatmiko Bambang , Revantoro Nemesius Bambang
Published: September 2024

Abstrak: Box culvert, yang terbuat dari beton bertulang, sering digunakan sebagai jembatan sederhana karena mampu menahan beban di atasnya. Berdasarkan metode pembuatannya, box culvert dibedakan menjadi dua jenis: precast, yang dicetak di area proyek atau pabrik, dan cast in situ, yang dibuat langsung di lokasi proyek. Penelitian ini bertujuan menganalisis efektivitas waktu dan efisiensi biaya antara kedua metode tersebut menggunakan software Primavera P6 dan IBM SPSS versi 25 untuk uji beda (t-test). Hasil penelitian menunjukkan bahwa box culvert precast memiliki waktu rencana 150 hari dan waktu aktual 83 hari, dengan efektivitas waktu 44,7 persen yang dikategorikan efektif. Sebaliknya, box culvert cast in situ memiliki waktu rencana 120 hari dan waktu aktual 59 hari, dengan efektivitas waktu 51,1 persen yang juga dikategorikan efektif. Dari segi biaya, box culvert precast mengalami biaya aktual sebesar Rp 3.346.178.247, lebih tinggi Rp 99.187.122 dari rencana biaya, sehingga dikategorikan tidak efisien dengan efisiensi -3,1 persen. Sedangkan cast in situ, dengan biaya aktual Rp 1.362.202.284, hanya selisih Rp 10.789.012 dari rencana, dengan efisiensi -0,8 persen dan juga dikategorikan tidak efisien. Uji beda (t-test) menunjukkan bahwa terdapat perbedaan signifikan dalam efektivitas waktu dan efisiensi biaya antara box culvert precast dan cast in situ. Penelitian ini memberikan wawasan penting bagi para praktisi konstruksi dalam memilih metode yang lebih efektif dan efisien untuk proyek-proyek serupa.
Permodelan pada Information Retrieval: Literature Review
Authors: Azizah Erwina Nurul , Handayani Anik Nur
Published: September 2024

Information Retrieval (IR) is a technique for finding information stored in relevant sources according to user needs. There are various ways to use IR, but this paper focuses on modeling which is used as a framework for information retrieval. There are three types of IR models developed in this paper. IR modeling techniques will be explained as proposed in the literature with a detailed description of the modes, such as Boolean and Region models. Also included are the advantages and disadvantages of each model.
Information Retrieval (IR) adalah teknik untuk menemukan sebuah informasi yang tersimpan pada sumber yang relevan sesuai dengan kebutuhan pengguna. Ada berbagai cara memanfaatkan IR, namun pada paper ini difokuskan pada permodelan yang dipakai sebagai kerangka dalam pengambilan informasi. Ada tiga jenis model IR yang dikembangkan pada paper ini. Teknik permodelan IR akan dijelaskan sesuai yang diusulkan di literatur dengan penjabaran terperinci tentang mode-model tersebut, seperti model Boolean dan Region. Disertakan juga keunggulan dan kelemahan masing-masing model.