bluuebunny/crossref_metadata_2025 huggingface dataset:
Individual placement and support programmes for young adults: Where are they and whom do they serve?
Authors: Al‐Abdulmunem Monirah , Bond Gary R. , Ressler Daniel R. , Becker Deborah R. , Swanson Sarah J. , Marbacher Jessica
Published: May 2023

Aim

Individual Placement and Support (IPS), an evidence‐based supported employment model developed for adults with serious mental illness, has been recently targeted to young adults with mental health conditions, but little is known about its adoption in this age group in the United States.

Methods

We recruited a volunteer sample of nine IPS programmes in five states serving young adults with mental health conditions aged 16 to 24. IPS team leaders reported programme and participant characteristics and rated barriers to employment and education.

Results

Most IPS programmes were located in community mental health centres, served a small number of young adults, and received most referrals from external sources. The study sample of 111 participants included 53% female, 47% under 21 years old, 60% diagnosed with a depressive disorder; 92% had an employment goal, and 40% had an education goal. IPS specialists reported that managing mental health symptoms was the most common barrier to achieving employment and education goals.

Conclusion

Future research should examine how IPS programmes could best provide services to young adults.
HUGO BALL'S RELIGIOUS CONVERSION
Authors: Lewer Deborah
Published: May 2023

This essay investigates the German ex‐Dadaist Hugo Ball (1886–1927) and his 1920s work on religious conversion from Paul, Augustine and Francis to writers and poets in modernity. This intense engagement was rooted in Ball's own radical conversion, or ‘re‐conversion’, to an austere form of the Catholicism of his childhood in 1920, just a few years after breaking with the Dada movement he had helped found in Zurich in 1916. In letters, books, his edited diaries and essays such as ‘Die religiöse Konversion’ of 1925, Ball wrestled with the phenomenon of conversion. He traced it in religious culture, monasticism, psychiatry and politics. This article explores Ball's imaginative emphasis on the condition of chaos that precedes resolution into ‘order’ in the convert. It considers his model of conversion not only as salvific but also as remedial and therapeutic. Further, it interrogates his connection of conversion with the breakdown of language in mysticism and in Dada. Ball's intensive study of the mystical theology of Pseudo‐Dionysius the Areopagite and others provided much of the epistemological ground for this work. More provocative was his imagined possibility of collective national ‘conversion’ to Catholicism – for the whole of Germany.
Thrombocytosis and eosinophilia in 32 Chinese neonatal incontinentia pigmenti
Authors: Su Yufei , Zhang Huifang , Zou Zongyi , Ma Yingge , Zhang Huiping , Wen Jun , Li Hui
Published: May 2023

Introduction

Incontinentia pigmenti (IP) is a rare X‐linked dominant genetic disease affecting ectodermal tissue and often misdiagnosed in the neonatal period. The aim of this study was to highlight sequential clinical features and evaluate prognosis of the 32 neonatal IP patients.

Material and methods

A retrospective descriptive analysis was performed, using the clinical, blood analytical, pathological, radiological, genetic, and followed‐up data of neonatal patients diagnosed with IP from 2010 to 2021, in Xi'an, China.

Results

Of the 32 patients, two (6.25%) were male. Thirty babies (93.75%) had eosinophilia (eosinophilic granulocyte count: 0.31–19.9 × 109, mean proportion of white blood cells: 20.98 ± 15.21%). Twenty babies (62.5%) had thrombocytosis (thrombocyte count: 139–975 × 109, mean count: 416.76 ± 176.82). Thirty‐one babies (96.88%) exhibited the first three cutaneous lesion stages characterized by erythema and superficial vesicles on inflammatory bases in a linear distribution in the first week of age. Thirteen babies (40%) combined nervous system abnormalities, and nine babies (28.13%) had retinopathy. Two types of genetic mutations were detected in the NEMO gene. Nineteen babies were followed up. According to the follow‐up, four babies displayed psychomotor retardation, and five babies developed a decrease in vision with astigmatism and amblyopia.

Conclusion

It is important that 30 babies (93.75%) had eosinophilia and 20 babies (62.5%) had thrombocytosis. Therefore, we speculate that the mechanism of the injury may be related to the platelet aggregation on the basis of the increase in eosinophil cells and the release of inflammatory factors.
Influence of feed moisture content on physical and sensory properties of extruded pure mung bean starch vermicelli
Authors: Nguyen Tien Phung , Lin Jenshinn , Songsermpong Sirichai
Published: May 2023

The extrusion process was studied to replace the traditional process of making mung bean vermicelli. The physical and sensory properties were studied of pure mung bean vermicelli made using a single‐screw extruder with different feed moisture contents of mung bean starch (35%, 40%, 45% or 50%). The degree of starch gelatinisation, water absorption, cooking loss and diameter of extruded vermicelli increased with increased feed moisture content. The extrusion temperature provided a more transparent vermicelli product at a higher feed moisture content. Compared with the commercial product using the traditional method, the extruded mung bean vermicelli had greater lightness (L*) and yellowness (b*) for the dried vermicelli and greater blueness (b*) for the cooked vermicelli. The tensile strength and elasticity decreased significantly with increased feed moisture content. The extruded mung bean vermicelli was ranked as ‘well satisfied’ by the panellists, especially, the vermicelli with a feed moisture content of 50%, which had the highest score in overall acceptability compared with the other conditions, including the commercial vermicelli. In conclusion, the extrusion method could be applied to produce good quality, pure mung bean vermicelli instead of the traditional method.
Integration of olfactory and auditory cues eliciting parental behavior
Authors: McRae Briana R. , Andreu Valentine , Marlin Bianca Jones
Published: May 2023

Parental care is crucial for the survival of all mammalian species. Given the evolutionary importance of parenting, this behavioral repertoire must be supported by circuitry that is innate but also capable of learning and flexibility – adjusting to changing environmental demands. In rodents, parental care is triggered by the perception of cues emitted by a pup. Caregiver‐pup interactions are often composed of multimodal sensory stimuli that require caregivers to integrate across sensory modalities. In this review, we focus on two sensory modalities essential for the parental experience: smell and hearing. We examine how smell and hearing are combined with other senses to identify offspring in need of care. Understanding how multimodal stimuli are integrated in the caregiver brain to inform parental behavior is an important step in understanding the circuitry that underlies this complex and crucial behavioral repertoire. In this review, we will discuss recent advances in the field of rodent parental behavior, highlighting studies that have begun to disentangle the neural circuitry that processes the multisensory cues that are involved in caregiver‐offspring interactions.
CO2‐induced chloroplast movement in one cell‐layer moss leaves
Authors: Sugiyama Taichi , Terashima Ichiro
Published: May 2023

CO2‐induced chloroplast movement was reported in the monograph by Gustav Senn in 1908: unilateral CO2 supply to the one cell‐layered moss leaves induced the positively CO2‐tactic periclinal arrangement of chloroplasts. Here, using the model moss plant Physcomitrium patens, we examined basic features of chloroplast CO2‐tactic relocation with a modernized experimental system. The CO2 relocation was light‐dependent and, especially, CO2 relocation in red light was substantially dependent on photosynthetic activity. In blue light, CO2 relocation was mainly dependent on microfilaments while microtubule‐based movement was insensitive to CO2, whereas in red light, both cytoskeletons contributed redundantly to CO2 relocation. The CO2 relocation was observed not only when the two leaf surfaces were exposed to CO2‐free air versus CO2‐containing air, but also by exposing them physiologically relevant differences in CO2 concentrations. In the leaves placed on the surface of a gel sheet, chloroplasts avoided the gel side and positioned in the air‐facing surface, and this phenomenon was also shown to be photosynthesis dependent. Based on these observations, we propose a hypothesis that the threshold light intensity between the light‐accumulation and ‐avoidance responses of the photorelocation would be increased by CO2, resulting in the CO2‐tactic relocation of chloroplasts.
Multimodal study of the neural sources of error monitoring in adolescents and adults
Authors: Conte Stefania , Richards John E. , Fox Nathan A. , Valadez Emilio A. , McSweeney Marco , Tan Enda , Pine Daniel S. , Winkler Anderson M. , Liuzzi Lucrezia , Cardinale Elise M. , White Lauren K. , Buzzell George A.
Published: May 2023

The ability to monitor performance during a goal‐directed behavior differs among children and adults in ways that can be measured with several tasks and techniques. As well, recent work has shown that individual differences in error monitoring moderate temperamental risk for anxiety and that this moderation changes with age. We investigated age differences in neural responses linked to performance monitoring using a multimodal approach. The approach combined functional MRI and source localization of event‐related potentials (ERPs) in 12‐year‐old, 15‐year‐old, and adult participants. Neural generators of two components related to performance and error monitoring, the N2 and ERN, lay within specific areas of fMRI clusters. Whereas correlates of the N2 component appeared similar across age groups, age‐related differences manifested in the location of the generators of the ERN component. The dorsal anterior cingulate cortex (dACC) was the predominant source location for the 12‐year‐old group; this area manifested posteriorly for the 15‐year‐old and adult groups. A fMRI‐based ROI analysis confirmed this pattern of activity. These results suggest that changes in the underlying neural mechanisms are related to developmental changes in performance monitoring.
Investigation of the effects of syringic acid supplemented to Tris semen diluent on ram semen freezability
Authors: Avdatek Fatih , İnanç Muhammed Enes , Gülhan Mehmet Fuat , Güngör Şükrü , Yeni Deniz , Olğaç Kemal Tuna , Denk Barış , Taşdemir Umut
Published: May 2023

To the best of our knowledge, no research has been conducted to test the effects of syringic acid (SA) on ram semen freezing within the scope of natural antioxidants added to semen extenders. Therefore, this study had two main objectives. First, to test whether adding SA to ram semen freezing extender has a protective effect and contributes positively to sperm kinetic, plasma and acrosome integrity, mitochondrial membrane potential, lipid peroxidation, oxidant and antioxidant and DNA damage parameters after thawing. Second, it was to determine at what concentration the SA supplemented to the extender could be applied by in vitro studies by preserving the fertilization ability of frozen semen at the highest level. In the study, six individuals of Sönmez rams were used. The semen was collected from the rams using an artificial vagina and pooled. The pooled semen was divided into five different groups and extended with 0, 0.5, 1, 2 and 4 mM SA (control C, SA0.5, SA1, SA2 and SA4, respectively). After dilution, the semen samples were kept at 4°C for 3 h, then loaded into 0.25 mL straws and frozen in liquid nitrogen vapour. The SA1 and SA2 groups were higher plasma membrane and acrosome integrity (PMAI), high mitochondrial membrane potential (HMMP), plasma membrane integrity and motility compared to other groups (p < .05). It was observed that SA supplemented to the Tris extender significantly reduced DNA damage, and the lowest values were obtained especially in the SA1 and SA2 treatments (p < .05). Also, lowest MDA level was determined at the SA1 and this was statistically significant compared to SA4 and C (p < .05). In conclusion, it was revealed that SA added to Tris semen extender at 1 and 2 mM treatment doses increased progressive and total motility and preserved PMAI, plasma membrane integrity, HMMP and DNA integrity.
p-adic Eichler–Shimura maps for the modular curve
Authors: Rodríguez Camargo Juan Esteban
Published: May 2023

We give a new proof of Faltings's $p$-adic Eichler–Shimura decomposition of the modular curves via Bernstein–Gelfand–Gelfand (BGG) methods and the Hodge–Tate period map. The key property is the relation between the Tate module and the Faltings extension, which was used in the original proof. Then we construct overconvergent Eichler–Shimura maps for the modular curves providing ‘the second half’ of the overconvergent Eichler–Shimura map of Andreatta, Iovita and Stevens. We use higher Coleman theory on the modular curve developed by Boxer and Pilloni to show that the small-slope part of the Eichler–Shimura maps interpolates the classical $p$-adic Eichler–Shimura decompositions. Finally, we prove that overconvergent Eichler–Shimura maps are compatible with Poincaré and Serre pairings.
NanJ Is the Major Sialidase for Clostridium perfringens Type F Food Poisoning Strain 01E809
Authors: Li Jihong , Pradhan Arhat , McClane Bruce A.
Published: May 2023

Clostridium perfringens
type F strains cause food poisoning (FP) when they sporulate and produce
C. perfringens
enterotoxin (CPE) in the intestines. Most type F FP strains carry a chromosomal
cpe
gene (c-
cpe
strains).
C. perfringens
produces up to three different sialidases, named NanH, NanI, and NanJ, but some c-
cpe
FP strains carry only
nanJ
and
nanH
genes.
Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure
Authors: Wu Yulong , Dong Zhouyan , Jiang Xinze , Qu Lei , Zhou Wei , Sun Xu , Hou Jiangshan , Xu Hongmei , Cheng Mei
Published: May 2023

Our study indicated that the gut microbiota contributes to spatial learning and memory dysfunction after chronic METH exposure, in which microglial phenotype status plays an intermediary role. The elucidated “specific microbiota taxa-microglial M1/M2 phenotypes-spatial learning and memory impairment” pathway would provide a novel mechanism and elucidate potential gut microbiota taxon targets for the no-drug treatment of cognitive deterioration after chronic METH exposure.
Supplemental Material: Stable tungsten isotopic composition of seawater over the past 80 million years
Authors: Yang Ruiyu , Li Gaojun , al. et
Published: May 2023

Sample pretreatment, analytical and calculation methods, and supplementary figures and tables.  
Supplemental Material: Valanginian climate cooling and environmental change driven by Paraná-Etendeka basalt erosion
Authors: Percival L.M.E. , al. et
Published: May 2023

Appendices S1–S2, Figure S1, and Tables S1–S2.  
Supplemental Material: Late Quaternary paleoceanography of Vestnesa Ridge, Fram Strait
Authors: Chu Rachel Wai Ching , Yasuhara Moriaki , al. et
Published: May 2023

Table S1 (ostracode census data, radiocarbon dates, and foraminiferal δ13C data). 
Supplemental Material: Impact of long-term erosion on crustal stresses and seismicity in stable continental regions
Authors: Mazzotti Stephane , al. et
Published: May 2023

Model setup, yield stress classes, lithosphere mechanical response, fault stability margin, and earthquake depths. 
2 Developing a militarily relevant ex-vivo model of traumatic injury and haemorrhagic shock
Authors: Cottey Laura , Stoll Alex , Stone John P , Entwistle Timothy R , Amin Kavit , Kerr Jak , Cowey William R , Corban JT Bowers , Smith Jason E , Watts Sarah , Fildes James E
Published: May 2023

Background

Traumatic injury is a leading cause of death worldwide. There is a crucial need to develop therapies that improve critically injured patient outcomes. Current trauma research models are ethically and financially challenging, with poor translation. However, traumatic injury and haemorrhagic shock can be modelled using ex-vivo normothermic perfusion (EVNP), a methodology adapted from transplantation. The aim of this study was to develop a 24hr EVNP duel porcine limb and kidney model.

Method

Eight porcine forelimbs, bilateral kidneys and blood were retrieved via standard protocols. Following <4hrs cold storage, the kidneys were connected to a bespoke Ex-Vivo Research Centre circuit via the renal artery, and a mean arterial pressure (MAP) of 80mmHg was maintained. The perfusate consisted of leukocyte-deplete blood and Ringer’s solution. Once the kidney was haemodynamically stable, the limb was connected via the brachial and radial collateral arteries. Haemodynamic parameters were continuously monitored, biochemical perfusate assessment performed hourly and histopathology baseline and end timepoints samples taken.

Results

Perfusion was maintained for 24hrs in all limbs, with blood flows of 345.03mls/min (±54.78 SD) and MAP of 77.57mmHg (±3.82 SD). Three kidneys achieved 24hr perfusion, with flows of 214.53mls/min (±41.6 SD) and MAP of 80.58mmHg (±0.51 SD). Biochemical analysis showed a statistically significant potassium elevation at 24hrs compared to baseline, p=0.0078. A further three kidneys were disconnected from the circuit at 7, 11 and 12hrs, and two kidneys showed decline in flow >15 hrs due to declining haemodynamics. Compared to baseline, evidence of cell death was observed in 24hr muscle samples. In the end-point kidney samples, tubular degeneration, protein loss and necrosis extended along the nephron.

Conclusions

Limb EVNP can be successfully achieved for 24hrs, but further protocol improvements are required to sustain renal perfusion for 24hrs alongside adjustments to reduce the ischaemic insult and cell death.
Evidence-based practice models and frameworks in the healthcare setting: a scoping review
Authors: Dusin Jarrod , Melanson Andrea , Mische-Lawson Lisa
Published: May 2023

Objectives

The aim of this scoping review was to identify and review current evidence-based practice (EBP) models and frameworks. Specifically, how EBP models and frameworks used in healthcare settings align with the original model of (1) asking the question, (2) acquiring the best evidence, (3) appraising the evidence, (4) applying the findings to clinical practice and (5) evaluating the outcomes of change, along with patient values and preferences and clinical skills.

Design

A Scoping review.

Included sources and articles

Published articles were identified through searches within electronic databases (MEDLINE, EMBASE, Scopus) from January 1990 to April 2022. The English language EBP models and frameworks included in the review all included the five main steps of EBP. Excluded were models and frameworks focused on one domain or strategy (eg, frameworks focused on applying findings).

Results

Of the 20 097 articles found by our search, 19 models and frameworks met our inclusion criteria. The results showed a diverse collection of models and frameworks. Many models and frameworks were well developed and widely used, with supporting validation and updates. Some models and frameworks provided many tools and contextual instruction, while others provided only general process instruction. The models and frameworks reviewed demonstrated that the user must possess EBP expertise and knowledge for the step of assessing evidence. The models and frameworks varied greatly in the level of instruction to assess the evidence. Only seven models and frameworks integrated patient values and preferences into their processes.

Conclusion

Many EBP models and frameworks currently exist that provide diverse instructions on the best way to use EBP. However, the inclusion of patient values and preferences needs to be better integrated into EBP models and frameworks. Also, the issues of EBP expertise and knowledge to assess evidence must be considered when choosing a model or framework.
Does knowledge have a half-life? An observational study analyzing the use of older citations in medical and scientific publications
Authors: Chow Natalie L.Y. , Tateishi Natalie , Goldhar Alexa , Zaheer Rabia , Redelmeier Donald A. , Cheung Amy H. , Schaffer Ayal , Sinyor Mark
Published: May 2023

Objectives

In the process of scientific progress, prior evidence is both relied on and supplanted by new discoveries. We use the term ‘knowledge half-life’ to refer to the phenomenon in which older knowledge is discounted in favour of newer research. By quantifying the knowledge half-life, we sought to determine whether research published in more recent years is preferentially cited over older research in medical and scientific articles.

Design

An observational study employing a directed, systematic search of current literature.

Data sources

BMJ,PNAS,JAMA,NEJM,The Annals of Internal Medicine,The Lancet,ScienceandNaturewere searched.

Eligibility criteria for selecting studies

Eight high-impact medical and scientific journals were sampled examining original research articles from the first issue of every year over a 25-year span (1996–2020). The outcome of interest was the difference between the publication year of the article and references cited, termed ‘citation lag’.

Data extraction and synthesis

Analysis of variance was used to identify significant differences in citation lag.

Results

A total of 726 articles and 17 895 references were included with a mean citation lag of 7.5±8.4 years. Across all journals, >70% of references had been published within 10 years of the citing article. Approximately 15%–20% of referenced articles were 10–19 years old, and articles more than 20 years old were cited infrequently. Medical journals articles had references with significantly shorter citation lags compared with general science journals (p≤0.01). Articles published before 2009 had references with significantly shorter citation lags compared with those published in 2010–2020 (p<0.001).

Conclusions

This study found evidence of a small increase in the citation of older research in medical and scientific literature over the past decade. This phenomenon deserves further characterisation and scrutiny to ensure that ‘old knowledge’ is not being lost.
Inner generalized Weyl algebras and their simplicity criteria
Authors: Bavula V. V.
Published: May 2023

The aim of the paper is to introduce a new class of rings — the inner generalized Weyl algebras (IGWA) — and to give simplicity criteria for them. For each IGWA [Formula: see text] a derivative series of IGWAs, [Formula: see text], is attached where [Formula: see text] is an arbitrary ordinal. In general, all rings [Formula: see text] are distinct. A new construction of rings, the inner [Formula: see text]-extension of a ring, is introduced (where [Formula: see text] and [Formula: see text] are endomorphisms of a ring [Formula: see text] and [Formula: see text]).
Engineering Themes in Plant Forms and Functions
Authors: Ohlendorf Rahel , Tan Nathanael Yi-Hsuen , Nakayama Naomi
Published: May 2023

Living structures constantly interact with the biotic and abiotic environment by sensing and responding via specialized functional parts. In other words, biological bodies embody highly functional machines and actuators. What are the signatures of engineering mechanisms in biology? In this review, we connect the dots in the literature to seek engineering principles in plant structures. We identify three thematic motifs—bilayer actuator, slender-bodied functional surface, and self-similarity—and provide an overview of their structure–function relationships. Unlike human-engineered machines and actuators, biological counterparts may appear suboptimal in design, loosely complying with physical theories or engineering principles. We postulate what factors may influence the evolution of functional morphology and anatomy to dissect and comprehend better the why behind the biological forms.
Water-Soluble Ions and Heavy Metal Levels, Source Apportionment, and Health Risk of Indoor Dust in the Mogao Grottoes of Dunhuang, China
Authors: Ma Xiaoyi , Xia Dunsheng , Zhang Guobin , Chen Peiyuan , Liu Xinying , Liu Hui , Wang Wanfu , Zhan Hongtao , Zhang Yixiao , Yu Qiao
Published: May 2023

The direct ingestion of indoor dust particles at historical heritage sites is a primary exposure pathway for employees to heavy metals. Water-soluble ions (WSIs) and heavy metal levels, sources, bioaccessibility, and health risks associated with indoor dust in the Mogao Grottoes were analyzed using comprehensive methods to determine the differences in the concentrations and distribution characteristics of WSIs and heavy metals between statue dust and floor dust. The concentrations of WSIs and heavy metals and the magnetic values of

χ

lf

and SIRM in indoor dust were higher than those in street dust and topsoil. The mean

χ

lf

and SIRM of statue dust particles were

100.3
×

10

−
8

 

m

3

k

g

−
1

and

1686.9
×
1

0

−
5

 

Am

2

k

g

−
1

. Specifically, the concentration of Pb was

277
 
mg
 
k

g

−
1

, 15-fold higher than the background value, indicating the continual receipt of heavy metals with high magnetic minerals during dust deposition. WSIs mainly originate from the weathering of surrounding rocks and earthen plaster; Pb originates from the shedding of paint of murals and sculptures; and Zn, Cu, and magnetic minerals originate from traffic sources. The bioaccessibility of heavy metals is high in the gastrointestinal phases of indoor dust. Overall, the health risks posed by heavy metals in indoor dust were low, with moderate to high risks in individual caves. Ingestion presents the highest noncarcinogenic and carcinogenic risk to employees. These results provide essential knowledge on indoor dust characteristics in the Mogao Grottoes, facilitating strategies for dust pollution mitigation and employee health risk control.
CNN-LSTM Model Optimized by Bayesian Optimization for Predicting Single-Well Production in Water Flooding Reservoir
Authors: Zhang Lei , Dou Hongen , Zhang Kun , Huang Ruijie , Lin Xia , Wu Shuhong , Zhang Rui , Zhang Chenjun , Zheng Shaojing
Published: May 2023

Geared toward the problems of predicting the unsteadily changing single oil well production in water flooding reservoir, a machine learning model based on CNN (convolutional neural network) and LSTM (long short-term memory) is established which realizes precise predictions of monthly single-well production. This study is considering more than 60 dynamic and static factors that affect the changes of oil well production, introduce water injection parameters into data set, select 11 main control factors, and then, build a CNN-LSTM model optimized by Bayesian optimization. The effectiveness of the proposed model is verified in a realistic reservoir. The experiment results show that the prediction accuracy of the proposed model is over 90%, which suggests a penitential application in an extensive range of applications. Production forecasting by the developed model is simple, efficient, and accurate, which can provide a guidance for the dynamic analysis of a water flooding reservoir, and work as a good reference of the development and production of other types of reservoirs.
Stress and Coping Mechanism among Students Residing in Private School Hostels
Authors: Shrestha Rajeev , Timalsina Sudha , Shakya Rajina , Shrestha Nita , Kotera Yasuhiro , Hashemy Tayeba , Ozaki Akihiko
Published: May 2023

Background. Mental health problems can significantly impact a student’s academic performance, career, health, and future if they are not identified and managed in time. The poor mental health of young people is a global problem, including in Nepal. However, the scenario of perceived stress among adolescent students residing in academic hostels is not explored in Nepal. Therefore, this study aimed at determining the prevalence of perceived stress with its associated predictors, experienced stressors, and coping mechanisms among adolescent students residing in private hostels in Nepal. Methods. A cross-sectional study design was employed among all adolescent students of grades six to ten who resided in eight school hostels in Nepal. A total of 209 students responded to self-administered validated questionnaires for perceived stress (PSS-10) and coping scales. Results. More than half (51.67%) of the students experienced symptoms of perceived stress. Strict discipline in the hostel (77.03%) and groupism based on religion (5.26%) were the most common and least common stressors experienced, respectively. One-third of the students (

n
=
70

, 33.5%) very often felt confident about handling personal problems. The presence of a mischievous element and neglect from friends were significant stressors determined. Seeking social support was the most used coping strategy over externalizing behaviours such as using bad words, yelling, and shouting. Conclusion. The study confirmed the presence of perceived stress among students living in hostels, where hostel residential factors were the predominant predictors. As a minority of the students can properly manage their stress, it is necessary to provide students with the appropriate educational counselling to help them deal with potential obstacles. Additionally, monitoring, increased communication with family and friends, and improving the hostel environment can be important in addressing students’ perceived stress.
A Method to Evaluate and Eliminate Fungal Contamination in Household Air Conditioners
Authors: Shiraishi Yoshiki , Harada Kazuhiro , Maeda Chikao , Ogino Fumitoshi , Suzuki Yu , Okada Naoki , Tomomatsu Katsuyoshi , Sekine Yoshika , Yanagi U. , Imanishi Tadashi , Oguma Tsuyoshi , Asano Koichiro
Published: May 2023

Background. Allergic fungal airway diseases, such as asthma and allergic bronchopulmonary mycosis (ABPM), are often difficult to manage with medical treatment alone; therefore, environmental fungal exposure should be accurately evaluated and minimized. In the present study, we established a method to evaluate and eliminate fungal contamination in household air conditioners (ACs). Methods. In the fall of 2020, an environmental survey of living rooms was conducted in 17 Japanese residences of patients with ABPM or related diseases. Household ductless minisplit AC units were disassembled to collect swab samples from the internal parts (filter, heat exchanger, blower fan, and air vent), followed by high-pressure washing. Fungal abundance and composition in swab samples and cleaning effluents of ACs as well as house dust and air samples were determined using quantitative PCR and next-generation sequencing of the internal transcribed spacer 1 region, respectively. A weighted UniFrac distance was calculated to analyze the similarity of the mycobiome among the samples. Results. All interior parts of ACs contained high levels of fungal DNA, with the blower fans being the most contaminated parts. Cladosporium and Toxicocladosporium, followed by Aureobasidium, Aspergillus, and Rhodotorula, were the most common fungi detected in the AC unit. High-pressure washing decreased fungal abundance by over 99% in all AC parts. Fungal abundance and composition in blower fans were strongly correlated with those in cleaning effluents. Conclusion. Interior parts downstream of heat exchangers in household ACs are the major sites of fungal contamination, possibly polluting the indoor air in the residences. High-pressure washing is highly effective for decontamination.
TABLE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Authors: Chaudhary Ritu , Slebos Robbert J.C. , Noel Leenil C. , Song Feifei , Poole Maria I. , Hoening Dirk S. , Hernandez-Prera Juan C. , Conejo-Garcia Jose R. , Guevara-Patino Jose A. , Wang Xuefeng , Xie Mengyu , Tan Aik Choon , Chung Christine H.
Published: May 2023

Disease control given pembrolizumab or nivolumab monotherapy in Moffitt retrospective study cohort
Supplementary Table S5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Authors: Chaudhary Ritu , Slebos Robbert J.C. , Noel Leenil C. , Song Feifei , Poole Maria I. , Hoening Dirk S. , Hernandez-Prera Juan C. , Conejo-Garcia Jose R. , Guevara-Patino Jose A. , Wang Xuefeng , Xie Mengyu , Tan Aik Choon , Chung Christine H.
Published: May 2023

Supplementary Table S5. Immune profile of the primary and recurrent tumors in Moffitt HNSCC cohort
Supplementary Table S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Authors: Chaudhary Ritu , Slebos Robbert J.C. , Noel Leenil C. , Song Feifei , Poole Maria I. , Hoening Dirk S. , Hernandez-Prera Juan C. , Conejo-Garcia Jose R. , Guevara-Patino Jose A. , Wang Xuefeng , Xie Mengyu , Tan Aik Choon , Chung Christine H.
Published: May 2023

Supplementary Table S1. TCGA Cohort
FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Authors: Chaudhary Ritu , Slebos Robbert J.C. , Noel Leenil C. , Song Feifei , Poole Maria I. , Hoening Dirk S. , Hernandez-Prera Juan C. , Conejo-Garcia Jose R. , Guevara-Patino Jose A. , Wang Xuefeng , Xie Mengyu , Tan Aik Choon , Chung Christine H.
Published: May 2023

Hypoxia subgroup has immunosuppressive TME. Boxplots showing cell counts distribution of different immune markers CAIX+ cells representing hypoxia marker (A), CD3+ T cells (B), CD8+ cytotoxic T cells (C), PCK+ tumor cells expressing PD-L1 (D), HLA-DR+ APCs (E), and CD8+ T cells/FOXP3+ Tregs (F), among the three subgroups in the TMA mIHC cohort (n = 90). Statistical analysis was performed by ANOVA test and followed by Tukey post hoc tests. G, Representative mIHC images showing that the average numbers of immune cells expressing CD3+ T cells (green color), CD8+ cytotoxic T cells (yellow color), CD69+ activated T cells (red color), CD103+ resident memory T cells (cyan color) within 20 μm of a PCK+ cell (orange color) was statistically significantly lowest in the Hypoxia subgroup compared with the Mixture and Immune subgroups. Nuclei are shown in blue. Individual TMA core was considered as a region of interest (ROI). Bottom panel represents the zoom-in distance proximity and spatial distribution between a tumor cell and an immune cell within the TME.
Art of the Counter-Archive: Rosângela Rennó's Books and the Secret Files of the Dictatorship
Authors: Bedran Marina
Published: May 2023

This article examines Brazilian artist Rosângela Rennó's books 2005–510117385–5 and A01 [COD.19.1.1.43] – A27 [S | COD.23], which engage with photographs stolen from public collections in Rio de Janeiro. Both books triggered a conversation about institutional precarity and its effects on national memory and cultural heritage—one that took place a few years before the 2018 fire at Rio de Janeiro's Museu Nacional, which destroyed much of its invaluable archive of twenty million items and was understood as a national tragedy. It discusses Rennó's books in light of 1960s and 1970s Latin American Conceptualisms, arguing that they propose new ways of understanding the secret files of the 1964–85 dictatorship—a still unresolved issue in Brazil. Tackling the dynamics of public museums, private collections, and incentive laws and activating the generative potential of circulation, Rennó's work provides both a commentary on the role of institutions and national memory and at the same time a warning against the unregulated circulation of the neoliberal market. Ultimately, it offers a critique of the archive's potential to be coopted to authoritarian ends and a model for a public, circulating counter-archive of collective memories.
Diagnosing Perpetual High Corruption in Cameroon: From Colonial Antecedents to Neo-imperialism
Authors: Tiky Lembe M.
Published: May 2023

Although every index of “perceived corruption” invariably ranks African nations amongst the most corrupt countries in the world, few studies have examined their particular situations to understand the causes of this “cancer.” This article analyses the causes of corruption in Cameroon, a country ranked twice as the most corrupt in the world. The analysis develops in theory triangulation to assess the following three hypotheses: (1) High Corruption in Cameroon is due to the weakness of its colonially inherited institutions and the country’s slow modernization; (2) High corruption results from the reinforcement of colonial institutions by postcolonial leaders in the context of the Cold War; and (3) The persistence of high corruption is due to path dependence and is linked to the structure of the world financial order that allows the laundering of ill-gotten wealth. Following the investigation of the causes and persistence of corruption is a discussion on its reduction, if not elimination. This research has implications for Cameroon institutions that must adopt the best-required policies to reduce corruption and boost economic development.
Discovery of Obesoconnus Jałoszyński in the Oriental Region (Coleoptera, Staphylinidae, Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: May 2023

To date, Obesoconnus Jałoszyński is known to occur in French Guiana, Mexico and Costa Rica. Here, two new species, O. asymmetricus sp. n. and O. pallidus sp. n., are reported to occur in Thailand. Scydmaenine genera showing a similar distribution are discussed, and since the ‘Alloraphes/Stenichnodes group’, to which Obesoconnus belongs, is known to occur in Neotropical, Afrotropical and Oriental regions, it is possible that in the future the genus may be discovered also in tropical Africa.
Mesoscale Factors Contributing to the Extreme Rainstorm on 20 July 2021 in Zhengzhou, China, as Revealed by Rapid Update 4DVar Analysis
Authors: Sun Juanzhen , Li Rumeng , Zhang Qinghong , Trier Stanley B. , Ying Zhuming , Xu Jun
Published: May 2023

The purpose of this study is to diagnose mesoscale factors responsible for the formation and development of an extreme rainstorm that occurred on 20 July 2021 in Zhengzhou, China. The rainstorm produced 201.9 mm of rainfall in 1 h, breaking the record of mainland China for 1-h rainfall accumulation in the past 73 years. Using 2-km continuously cycled analyses with 6-min updates that were produced by assimilating observations from radar and dense surface networks with a four-dimensional variational (4DVar) data assimilation system, we illustrate that the modification of environmental easterlies by three mesoscale disturbances played a critical role in the development of the rainstorm. Among the three systems, a mesobeta-scale low pressure system (mesolow) that developed from an inverted trough southwest of Zhengzhou was key to the formation and intensification of the rainstorm. We show that the rainstorm formed via sequential merging of three convective cells, which initiated along the convergence bands in the mesolow. Further, we present evidence to suggest that the mesolow and two terrain-influenced flows near the Taihang Mountains north of Zhengzhou, including a barrier jet and a downslope flow, contributed to the local intensification of the rainstorm and the intense 1-h rainfall. The three mesoscale features coexisted near Zhengzhou in the several hours before the extreme 1-h rainfall and enhanced local wind convergence and moisture transport synergistically. Our analysis also indicated that the strong midlevel south/southwesterly winds from the mesolow along with the gravity-current-modified low-level northeasterly barrier jet enhanced the vertical wind shear, which provided favorable local environment supporting the severe rainstorm.
Under God, indivisible? Religious salience and interstate territorial conflict
Authors: Zellman Ariel , Fox Jonathan
Published: May 2023

How and under what conditions do religious factors explain the militarization of interstate territorial disputes? We argue that inconclusive findings in previous studies stem from inadequate consideration of the interaction between challenger state religiosity and the domestic constituencies actually invested in religiously salient territorial claims. To address this gap, this article differentiates between secular regimes, which provide minimal support to their state’s dominant religion and religious regimes, which strongly support their dominant religion. It also considers narrowly salient coreligionist populations, which appeal almost exclusively to religious audiences, versus broadly salient contested sacred sites, which appeal to much broader constituencies. We argue that the interaction between these two factors produces very different patterns of interstate conflict behavior. Secular regimes avoid escalation over narrowly salient religious claims because they do not depend upon religious constituents for support. However, they lack the necessary religious legitimacy to manage outbidding challenges that frequently arise over more broadly salient claims. Religious regimes, by contrast, enjoy high domestic religious legitimacy, enabling more peaceful engagement with broadly salient religious claims. Yet their political dependence upon religious constituencies incentivizes conflict when disputes involve narrowly salient religious claims. We test these propositions utilizing original data on the religious salience of interstate territorial disputes in the post-Cold War era, from 1990 to 2010. Analyses, using both dichotomous and continuous measures of regime religiosity, confirm these inferences and contribute to highly nuanced understandings of how state-religion policy and religious salience interact to influence patterns of interstate violence.
Self-Regulated Strategy Development for Algebra Problem Solving
Authors: Mulcahy Candace A. , Gagnon Joseph C. , Atkinson V. Sue , Miller Jason A.
Published: May 2023

In the era of 21st century learning, many secondary students with learning disabilities continue to struggle with mathematics problem solving. Emerging evidence suggests self-regulated strategy development can be combined with existing evidence-based and promising practices during mathematics instruction. These practices include explicit instruction, metacognition, use of visual representations, ongoing formative assessment and feedback, multiple examples, and self-regulation. We describe the promising and practical potential of SRSD and STAR, a research-based, metacognitive problem-solving strategy, for instruction in algebraic problem-solving. A practical example is provided to illustrate the combination of practices.
Feature reassembly and L1 preemption: Acquiring CLLD in L2 Italian and L2 Romanian
Authors: Smeets Liz
Published: May 2023

This study investigates feature acquisition and feature reassembly associated with Clitic Left Dislocation (CLLD). The article compares the acquisition of CLLD in second language (L2) Italian to L2 Romanian to examine effects of first language (L1) transfer, construction frequency and the type of interface involved (external vs. internal interface) within the same syntactic construction. The results from an acceptability judgment task and a written elicitation task show that while English near-native speakers of Italian/Romanian acquired the L2 constraints on CLLD, which is [+anaphor] for Italian and [+specific] for Romanian, data from both Romanian L2 learners of Italian and Italian L2 learners of Romanian showed persistent L1 transfer effects. Target-like acquisition for these groups requires both grammatical expansion and retraction; Romanian CLLD requires the addition of an L1-unavailable [+specific] feature and the loss of a [+anaphor] feature, while Italian CLLD requires the addition of an L1-unavailable [+anaphor] and the loss of a [+specific] feature. The reported findings extend evidence in favour of the Feature Reassembly Hypothesis to the syntax–discourse interface, as reassembly of interpretational features associated with CLLD proved more difficult than feature acquisition. While learners at the near-native levels were able to broaden the contexts that allow a clitic in the L2 (grammatical expansion), L1 preemption difficulties were attested as well. This was the case regardless of the frequency of the relevant construction in the input and the type of L2 feature that needed to be added/removed.
Temporalities in Translation. Anthropocene Futures, the SDGs and Justice in Baltimore
Authors: Knappe Henrike
Published: May 2023

Within the Sustainable Development Goals (SDGs) process, different futures are contested, negotiated and become embedded in the Anthropocene. Those futures travel from one city to another, from businesses to local schools, or from protest events to the international negotiation fora of the United Nation (UN). By investigating the translation practices of Anthropocene futures from the global context of the UN into the local context of the city of Baltimore (United States), this paper traces how local actors engage with global norms and how they gain or lose agency in this process. Putting forward imaginaries of past, present and futures are practices of norm translation and appropriation that clearly change the once envisioned global future narratives. The paper brings together the Anthropocene scholarship with the International Relations-literature on translation. I suggest a new conceptual approach of translation that includes notions of ruptures, discontinuities and present pasts as main factors in translation processes. I apply this new framework to the case of SDG localization in Baltimore. In doing so, I analyse three major reports and 10 qualitative interviews that I conducted with local actors from the university, the city administration as well as different civil society actors in 2018. Here, I will discuss the different temporal notions, more specifically the way futures and pasts intersect in non-linear processes of translation.
A case series evaluating the effect of esmolol therapy to treat hypoxemia in COVID-19 patients on VV-ECMO
Authors: Kim Bo Soo , Keller Steven P , Dodd-o Jeffrey M
Published: May 2023

When COVID-19 ARDS abolishes pulmonary function, VV-ECMO can provide gas exchange. If oxygenation remains insufficient despite maximal VV-ECMO support, the addition of esmolol has been proposed. Conflict exists, however, as to the oxygenation level which should trigger beta-blocker initiation. We evaluated the effect of esmolol therapy on oxygenation and oxygen delivery in patients with negligible native lung function and various degrees of hypoxemia despite maximal VV-ECMO support. We found that, in COVID-19 patients with negligible pulmonary gas exchange, the generalized use of esmolol administration to raise arterial oxygenation by slowing heart rate and thereby match native cardiac output to maximal attainable VV ECMO flows actually reduces systemic oxygen delivery in many cases.