bluuebunny/crossref_metadata_2025 huggingface dataset:
Terpenoids from Octocorals of the Genus Pachyclavularia
Authors: Chang Yu-Chia , Sheu Jyh-Horng , Wu Yang-Chang , Sung Ping-Jyun
Published: December 2017

In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along with studies of their biological activities, are summarized in this review. Based on the literature, many of these compounds possess bioactivities, including anti-inflammation properties, cytotoxicity, and ichthyotoxicity, suggesting that they may have the potential to be developed into biomedical agents for treatment.
De Novo RNA Sequencing and Expression Analysis of Aconitum carmichaelii to Analyze Key Genes Involved in the Biosynthesis of Diterpene Alkaloids
Authors: Rai Megha , Rai Amit , Kawano Noriaki , Yoshimatsu Kayo , Takahashi Hiroki , Suzuki Hideyuki , Kawahara Nobuo , Saito Kazuki , Yamazaki Mami
Published: December 2017

Aconitum carmichaelii is an important medicinal herb used widely in China, Japan, India, Korea, and other Asian countries. While extensive research on the characterization of metabolic extracts of A. carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene alkaloids, its biosynthetic pathway remains largely unknown. Biosynthesis of these secondary metabolites is tightly controlled and mostly occurs in a tissue-specific manner; therefore, transcriptome analysis across multiple tissues is an attractive method to identify the molecular components involved for further functional characterization. In order to understand the biosynthesis of secondary metabolites, Illumina-based deep transcriptome profiling and analysis was performed for four tissues (flower, bud, leaf, and root) of A. carmichaelii, resulting in 5.5 Gbps clean RNA-seq reads assembled into 128,183 unigenes. Unigenes annotated as possible rate-determining steps of an aconitine-type biosynthetic pathway were highly expressed in the root, in accordance with previous reports describing the root as the accumulation site for these metabolites. We also identified 21 unigenes annotated as cytochrome P450s and highly expressed in roots, which represent candidate unigenes involved in the diversification of secondary metabolites. Comparative transcriptome analysis of A. carmichaelii with A. heterophyllum identified 20,232 orthogroups, representing 30,633 unigenes of A. carmichaelii, gene ontology enrichment analysis of which revealed essential biological process together with a secondary metabolic process to be highly enriched. Unigenes identified in this study are strong candidates for aconitine-type diterpene alkaloid biosynthesis, and will serve as useful resources for further validation studies.
Antioxidant Potential of Fruit Juice with Added Chokeberry Powder (Aronia melanocarpa)
Authors: Šic Žlabur Jana , Dobričević Nadica , Pliestić Stjepan , Galić Ante , Bilić Daniela , Voća Sandra
Published: December 2017

The purpose of this study was to determine the possibility of using chokeberry powder as a supplement in apple juice to increase the nutritional value of the final product with the aim of developing a new functional food product. Also, to determine the influence of ultrasound assisted extraction on the bioactive compounds content, nutritional composition and antioxidant potential of apple juice with added chokeberry powder. The juice samples with added chokeberry powder had higher antioxidant capacity, irrespective of the extraction technique used. Apple juice samples with added chokeberry powder treated with high intensity ultrasound had significantly higher content of all analyzed bioactive compounds. The application of high intensity ultrasound significantly reduced the extraction time of the plant material. A positive correlation between vitamin C content, total phenols, flavonoids and anthocyanins content and antioxidant capacity was determined in juice samples with added chokeberry powder treated with high intensity ultrasound.
Effect of Graphene Oxide (GO) on the Morphology and Microstructure of Cement Hydration Products
Authors: Wang Liguo , Zhang Shupeng , Zheng Dapeng , Yang Haibin , Cui Hongzhi , Tang Waiching , Li Dongxu
Published: December 2017

In this study, the effects of graphene oxide (GO) on the microstructure of cement mortars were studied using scanning electron microscopy (SEM), thermogravimetric (TG), and X-ray diffraction (XRD) techniques. Cement mortar samples with different proportions of GO (0.02, 0.04, 0.06, and 0.08 wt % based on the weight of cement) were prepared. The test results showed that GO affected the crystallization of cement hydration products, C–S–H (calcium silicate hydrate is the main hydrate product) and CH (calcium hydroxide). The morphology of hydration products changed with the increase of GO content. Furthermore, the results of XRD analyses showed that the diffraction peak intensity and the crystal grain size of CH (001), (100), (101), and (102) for GO samples increased considerably compared with the control sample. Based on the results, it can be understood that GO can modify the crystal surface of CH, leading to the formation of larger crystals.
The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women
Authors: Hsu Chao-Chin , Kuo Hsin-Chih , Huang Ko-En
Published: December 2017

The efficacy of phytosterols extracted from Diascorea alata on antioxidant activities, plasma lipids and hematological profiles was assessed in postmenopausal women. Gas chromatography and mass spectrophotometry was employed to determine the steroid content of Taiwanese yam (Diascorea alata cv. Tainung No. 2). A two-center, randomized, double-blind, placebo-controlled clinical investigation on 50 postmenopausal women randomly assigned to two groups treated for 12 months with placebo or two sachets daily of Diascorea extracts containing 12 mg/dose was carried out. The main outcome measures were the plasma antioxidant activities, hematological profiles, and the concentrations of plasma lipids, including cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, very low density lipoprotein,, and apolipoprotein A1 and B. A one-way analysis of covariance (ANCOVA) test was performed to investigate the significance. Beta-sitosterol, stigmasterol, 22-23-dihydro-, and γ-sitosterol were major phytosterols determined from Diascorea extracts. At six months in those receiving Diascorea, there were significantly decreased leukocyte counts (p < 0.01) and improvement on antioxidant activity of malondialdehyde (p < 0.001). After 12 months’ treatment, elevations of hematocrit and mean corpuscular volume (p < 0.01) were noted in those receiving Diascorea. Moreover, the low dose Diascorea consumption in menopausal women for one year generally did not present positive effects on lipid profiles.
Effect of Grazing Behavior on Weight Regain Post-Bariatric Surgery: A Systematic Review
Authors: Pizato Nathalia , Botelho Patrícia , Gonçalves Vivian , Dutra Eliane , De Carvalho Kênia
Published: December 2017

Grazing, a type of maladaptive eating behavior, has been associated with poor weight outcomes in bariatric patients. The purpose of this study was to conduct a systematic review of the association between grazing behavior and weight regain post-bariatric surgery. Literature searches, study selection, design of the method, and quality appraisal were carried out by two independent authors. The search strategy was performed until October 2017 in Medline, Embase, Cochrane, Lilacs, Scopus, Web of Science, Google Scholar, ProQuest Dissertation & Theses, and Open Grey. Of a total of 3764 articles, five papers met the inclusion criteria (four original articles and one thesis), comprising 994 subjects, mostly women. The prevalence of grazing behavior ranged from 16.6 to 46.6%, and the highest prevalence of significant weight regain was 47%. The association between grazing and weight regain was observed in four of the five evaluated studies. Our findings support an association between grazing behavior and weight regain after bariatric surgery, regardless of surgery type and contextual concept of grazing. Further studies are needed to confirm the clarity of the real prevalence and interfering factors related to grazing behavior and weight outcomes.
Melatonin Efficacy in Obese Leptin-Deficient Mice Heart
Authors: Stacchiotti Alessandra , Favero Gaia , Giugno Lorena , Golic Igor , Korac Aleksandra , Rezzani Rita
Published: December 2017

Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria and sarcoplasmic reticulum necessary for calcium flux and contraction. Melatonin, important indoleamine secreted by the pineal gland during darkness, also has important cardioprotective properties. We designed the present study to define morphological and ultrastructural changes in cardiomyocytes and mainly in mitochondria of an animal model of obesity (ob/ob mice), when treated orally or not with melatonin at 100 mg/kg/day for 8 weeks (from 5 up to 13 week of life). We observed that ob/ob mice mitochondria in sub-sarcolemmal and inter-myofibrillar compartments are often devoid of cristae with an abnormally large size, which are called mega-mitochondria. Moreover, in ob/ob mice the hypertrophic cardiomyocytes expressed high level of 4hydroxy-2-nonenal (4HNE), a marker of lipid peroxidation but scarce degree of mitofusin2, indicative of mitochondrial sufferance. Melatonin oral supplementation in ob/ob mice restores mitochondrial cristae, enhances mitofusin2 expression and minimizes 4HNE and p62/SQSTM1, an index of aberrant autophagic flux. At pericardial fat level, adipose tissue depot strictly associated with myocardium infarction, melatonin reduces adipocyte hypertrophy and inversely regulates 4HNE and adiponectin expressions. In summary, melatonin might represent a safe dietary adjuvant to hamper cardiac mitochondria remodeling and the hypoxic status that occur in pre-diabetic obese mice at 13 weeks of life.
Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models
Authors: Jegal Jonghwan , Park No-June , Bong Sim-Kyu , Jegal Hyun , Kim Su-Nam , Yang Min
Published: December 2017

Dioscorea quinqueloba has been used for food substances, as well as in herbal medicines for allergic diseases such as asthma. This study aimed to investigate the anti-atopic dermatitis (AD) effects of the total extract of D. quinqueloba rhizomes and active fractionson murine oxazolone- and 2,4-dinitrochlorobenzene-induced models of AD. Specific AD symptoms, such as erythema, ear swelling, and epidermis thickening, were significantly reduced in the oxazolone-mediated AD BALB/c mice upon topical application of D. quinqueloba rhizomes 95% EtOH extract (DQ). DQEA (D. quinqueloba rhizomes EtOAc fraction) was beneficial for protecting the skin barrier against AD in DNCB-sensitized SKH-1 hairless mice. Decreased total serum IgE and IL-4 levels could be observed in atopic dorsal skin samples of the DQEA-treated group. On the basis of the phytochemical analysis, DQEA was found to contain dioscin and gracillin as its main compounds. Therapeutic applications with D. quinqueloba might be useful in the treatment of AD and related inflammatory skin diseases.
The Preparations and Water Vapor Barrier Properties of Polyimide Films Containing Amide Moieties
Authors: Zhang Kai , Yu Qiaoxi , Zhu Longji , Liu Siwei , Chi Zhenguo , Chen Xudong , Zhang Yi , Xu Jiarui
Published: December 2017

Flexible displays are a systematic revolution in the field of display, in which high-performance and high-barrier polymer substrates are considered to be one of the most important key materials. In this work, high water vapor barrier polyimides containing amide moieties were synthesized via the ternary polymerization of 4,4′-diaminobenzailide (DABA), 4,4′-diaminodipheny ether (ODA), and 3,3′,4,4′-biphenyl-tetracarboxylic acid dianhydride (BPDA) followed by thermal imidization. The relationship between the content of amide moieties and the water vapor barrier property of the prepared polyimides was studied by means of density test, water absorbing test, water contact angle test, water vapor permeation test, fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), thermogravimetry coupled with fourier transform infrared spectrometry (TG-FTIR), wide-angle X-ray diffraction analysis (WXRD), mechanical performance test, etc. The results show that the introduction of amide groups into polyimide (PI) main chains can improve the water vapor barrier properties of the polyimides effectively. The water vapor transmission rate (WVTR) of the polyimide films can be improved from 8.2365 g·(m2·24 h)−1 to 0.8670 g·(m2·24 h)−1 with the increasing content of amide moieties.
Land Use Classification: A Surface Energy Balance and Vegetation Index Application to Map and Monitor Irrigated Lands
Authors: Pun Mahesh , Mutiibwa Denis , Li Ruopu
Published: December 2017

Irrigated agriculture consumes the largest share of available fresh water, and awareness of the spatial distribution and application rates is paramount to a functional and sustainable communal consumptive water use. This remote sensing study leverages surface energy balance fluxes and vegetation indices to classify and map the spatial distribution of irrigated and non-irrigated croplands. The purpose is to introduce a classification scheme applicable across a wide variation in regional climate and inter-growing seasonal precipitation. The rationale for climate and inter-growing seasonal adaptability is founded in the derivation and calibration of the scheme based on the wettest growing season. Therefore, the scheme becomes a more efficient classifier during normal and dry growing seasons. Using empirical distribution functions, two indices are derived from evapotranspiration fluxes and vegetation indices to contrast and classify irrigated croplands from non-irrigated. The synergy of the two indices increases the classification proficiency by adding another classifying layer which re-characterizes misclassified croplands by the base index. The scheme was applied to a region with wide climate variation and to multiple years of growing seasons. The results presented, in cross validation with groundtruth, show an accurate and consistent approach to classify irrigation with overall accuracy of 92.1%, applicable from humid to semi-arid climate, and from dry to normal and wet growing seasons.
Quartz Crystal Microbalance Electronic Interfacing Systems: A Review
Authors: Alassi Abdulrahman , Benammar Mohieddine , Brett Dan
Published: December 2017

Quartz Crystal Microbalance (QCM) sensors are actively being implemented in various fields due to their compatibility with different operating conditions in gaseous/liquid mediums for a wide range of measurements. This trend has been matched by the parallel advancement in tailored electronic interfacing systems for QCM sensors. That is, selecting the appropriate electronic circuit is vital for accurate sensor measurements. Many techniques were developed over time to cover the expanding measurement requirements (e.g., accommodating highly-damping environments). This paper presents a comprehensive review of the various existing QCM electronic interfacing systems. Namely, impedance-based analysis, oscillators (conventional and lock-in based techniques), exponential decay methods and the emerging phase-mass based characterization. The aforementioned methods are discussed in detail and qualitatively compared in terms of their performance for various applications. In addition, some theoretical improvements and recommendations are introduced for adequate systems implementation. Finally, specific design considerations of high-temperature microbalance systems (e.g., GaPO4 crystals (GCM) and Langasite crystals (LCM)) are introduced, while assessing their overall system performance, stability and quality compared to conventional low-temperature applications.
Gas Leak Detection by Dilution of Atmospheric Oxygen
Authors: Lambrecht Armin , Maier Eric , Pernau Hans-Fridtjof , Strahl Thomas , Herbst Johannes
Published: December 2017

Gas leak detection is an important issue in infrastructure monitoring and industrial production. In this context, infrared (IR) absorption spectroscopy is a major measurement method. It can be applied in an extractive or remote detection scheme. Tunable laser spectroscopy (TLS) instruments are able to detect CH4 leaks with column densities below 10 ppm·m from a distance of 30 m in less than a second. However, leak detection of non-IR absorbing gases such as N2 is not possible in this manner. Due to the fact that any leaking gas displaces or dilutes the surrounding background gas, an indirect detection is still possible. It is shown by sensitive TLS measurements of the ambient background concentration of O2 that N2 leaks can be localized with extractive and standoff methods for distances below 1 m. Minimum leak rates of 0.1 mbar·L/s were determined. Flow simulations confirm that the leakage gas typically effuses in a narrow jet. The sensitivity is mainly determined by ambient flow conditions. Compared to TLS detection of CH4 at 1651 nm, the indirect method using O2 at 761 nm is experimentally found to be less sensitive by a factor of 100. However, the well-established TLS of O2 may become a universal tool for rapid leakage screening of vessels that contain unknown or inexpensive gases, such as N2.
A Study about Kalman Filters Applied to Embedded Sensors
Authors: Valade Aurélien , Acco Pascal , Grabolosa Pierre , Fourniols Jean-Yves
Published: December 2017

Over the last decade, smart sensors have grown in complexity and can now handle multiple measurement sources. This work establishes a methodology to achieve better estimates of physical values by processing raw measurements within a sensor using multi-physical models and Kalman filters for data fusion. A driving constraint being production cost and power consumption, this methodology focuses on algorithmic complexity while meeting real-time constraints and improving both precision and reliability despite low power processors limitations. Consequently, processing time available for other tasks is maximized. The known problem of estimating a 2D orientation using an inertial measurement unit with automatic gyroscope bias compensation will be used to illustrate the proposed methodology applied to a low power STM32L053 microcontroller. This application shows promising results with a processing time of 1.18 ms at 32 MHz with a 3.8% CPU usage due to the computation at a 26 Hz measurement and estimation rate.
Application of a Saddle-Type Eddy Current Sensor in Steel Ball Surface-Defect Inspection
Authors: Zhang Huayu , Zhong Mingming , Xie Fengqin , Cao Maoyong
Published: December 2017

Steel ball surface-defect inspection was performed by using a new saddle-type eddy current sensor (SECS), which included a saddle coil and a signal conditioning circuit. The saddle coil was directly wound on the steel ball’s outer bracket in a semi-circumferential direction. Driven by a friction wheel, the test steel ball rotated in a one-dimensional direction, such that the steel ball surface was fully scanned by the SECS. There were two purposes for using the SECS in the steel ball inspection system: one was to reduce the complexity of the unfolding wheel of the surface deployment mechanism, and the other was to reduce the difficulty of sensor processing and installation. Experiments were carried out on bearing steel balls in diameter of 8 mm with three types of representative and typical defects by using the SECS, and the results showed that the inspection system can detect surface defects as small as 0.05 mm in width and 0.1 mm in depth with high-repetition detection accuracy, and the detection efficiency of 5 pcs/s, which meet the requirement for inspecting ISO grade 10 bearing steel balls. The feasibility of detecting steel ball surface defects by SECS was verified.
Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links
Authors: Liu Tong , Liang Zhuo-qian
Published: December 2017

This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF) links for path-dependent walker classification. The fluctuated received signal strength (RSS) sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ) and hidden Markov models (HMMs) are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios are conducted to validate the proposed method.
Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects
Authors: Deng Shijie , Wang Peng , Yu Xinglong
Published: December 2017

Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry. This paper summarizes the fundamentals of phase-sensitive SPR sensing, reviews the available methods for phase interrogation of these sensors, and discusses the future prospects for and trends in the development of this technology.
Becoming Part of an Eco-Community: Social and Environmental Activism or Livelihood Strategy?
Authors: Escribano Paula , Lubbers Miranda , Molina José
Published: December 2017

Studying grassroots initiatives which aim to respond to environmental and social crisis is of renewed importance nowadays, in the aftermath of the 2008-9 financial crisis in southern Europe. This paper studies people’s motivations for becoming part of an eco-community in Catalonia, Spain, through interviews with 29 informants. The research is part of a larger study, based on ethnographic data collected between 2013 and 2015 in 27 eco-communities. The paper shows the extent to which people who joined an eco-community were driven by ideological reasons, adopting a livelihood strategy, or by a combination of both factors in the years following the crisis. We argue that the social and economic crisis has had an impact on the factors motivating people to join these communities, with an increase in the number of people driven by materialistic motives, relative to those who joined for ideological reasons.
Life Cycle Assessment Modelling of Greenhouse Gas Emissions from Existing and Proposed Municipal Solid Waste Management System of Lahore, Pakistan
Authors: Syeda Adila , Jadoon Anwar , Nawaz Chaudhry Mahuammad
Published: December 2017

Open Dumping of indiscriminate municipal solid waste (MSW) remarkably contributes to global warming (GW). Life Cycle Assessment modelling may be a useful tool for assessing the best waste management option regarding GW potential. The current study evaluates the contribution of an existing MSW management (MSWM) system to greenhouse gases in Gulberg Town, Lahore, Pakistan. This research also presents a comparison of scenarios with different waste management options. Life Cycle Assessment methodology has been used to conduct the study. EASETECH has been used for modelling. The short-term scenarios (STSs) have been developed to promote the thinking of integration of treatment technologies in the current waste management system within a few months. The results show that the major contribution to the total emissions comes from the anaerobic digestion of organic material from open waste dumps. Currently, recycling is the best treatment option for reducing the CO2-eq values in the study area. It was clarified that recycling is the best option for reducing the CO2-eq values, whereas biogasification comes in second in terms of savings and reduction. The integration of recycling and biogasification techniques would be a good solution.
Innovative Production Scheduling with Customer Satisfaction Based Measurement for the Sustainability of Manufacturing Firms
Authors: Shim Sang-Oh , Park KyungBae , Choi SungYong
Published: December 2017

Scheduling problems for the sustainability of manufacturing firms in the era of the fourth industrial revolution is addressed in this research. In terms of open innovation, innovative production scheduling can be defined as scheduling using big data, cyber-physical systems, internet of things, cloud computing, mobile network, and so on. In this environment, one of the most important things is to develop an innovative scheduling algorithm for the sustainability of manufacturing firms. In this research, a flexible flowshop scheduling problem is considered with the properties of sequence-dependent setup and different process plans for jobs. In a flexible flowshop, there are serial workstations with multiple pieces of equipment that are able to process multiple lots simultaneously. Since the scheduling in this workshop is known to be extremely difficult, it is important to devise an efficient and effective scheduling algorithm. In this research, a heuristic algorithm is proposed based on a few dispatching rules and economic lot size model with the objective of minimizing total tardiness of orders. For the purposes of performance evaluation, a simulation study is conducted on randomly generated problem instances. The results imply that our proposed method outperforms the existing ones, and greatly enhances the sustainability of manufacturing firms.
User-Generated Social Media Events in Tourism
Authors: Marine-Roig Estela , Martin-Fuentes Eva , Daries-Ramon Natalia
Published: December 2017

Social media and mobile technologies have revolutionised communication and particular attention has been given to user-generated content (UGC) and the formation of online communities; however, little attention has been given to tourist events entirely generated by users through social media. This paper aims to define and characterise the phenomenon of tourism user-generated events (UGEs) through social media around the user’s new empowered role and to assess user-generated social media events’ online socialness. It is also our aim to provide a useful mixed-methodology analysis framework for UGEs in relation to social media and to highlight their interest for organisations. The methodological approach includes a quantitative model to store, analyse and compare events’ online socialness, which is combined with qualitative, participant observation at the events. This approach is applied to the analysis of three Instagram meetups organised by a specific online community at Catalan ski resorts. The paper’s results show the differential characteristic of tourism UGEs: user initiative and empowerment, full organisation and structure, great social media use and UGC production, brand dissemination, attraction capacity, strong online community bond and faithfulness. With UGEs, an event management paradigm shift occurs as organisations are no longer the main initiators and controllers of the event.
A Study for Parametric Morphogeometric Operators to Assist the Detection of Keratoconus
Authors: Bataille Laurent , Cavas-Martínez Francisco , Fernández-Pacheco Daniel G. , Cañavate Francisco J. F. , Alio Jorge L.
Published: December 2017

The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression.
Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity
Authors: Pace Clare , Dagda Ruben , Angermann Jeff
Published: December 2017

Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promyelotic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. Many of the toxic effects of arsenic are mediated by mitochondrial dysfunction and related to arsenic’s effect on oxidative stress. Therefore, we investigated the effectiveness of antioxidants against arsenic induced cardiovascular dysfunction. A growing body of evidence suggests that antioxidant phytonutrients may ameliorate the toxic effects of arsenic on mitochondria by scavenging free radicals. This review identifies 21 antioxidants that can effectively reverse mitochondrial dysfunction and oxidative stress in cardiovascular cells and tissues. In addition, we propose that antioxidants have the potential to improve the cardiovascular health of millions of people chronically exposed to elevated arsenic concentrations through contaminated water supplies or used to treat certain types of leukemias. Importantly, we identify conceptual gaps in research and development of new mito-protective antioxidants and suggest avenues for future research to improve bioavailability of antioxidants and distribution to target tissues in order reduce arsenic-induced cardiovascular toxicity in a real-world context.
Tourism as a Perpetuator of Harmful Traditional Practices in Ethiopia's Hamer Community
Authors: Kifle Ermias , Tensay Azmach
Published: December 2017

The main objective of this research is to examine whether tourism is a key factor for the presence and continuation of harmful traditional practices (HTP) in the Hamer community in Ethiopia. Structural interviews survey with local people, informant in-depth interviews, and focus group
discussion were used for data collection. Both quantitative and qualitative data analysis techniques were used for this research. The finding shows that out of the three most prevalent HTP, whipping of women was found to be directly influenced by tourism. Local peoples, local government, local
associations, and private hospitality and tourism sectors have gained economic benefit from tourism. The majority of local people (90%) practice bull jumping and evangadi dance primarily for non-tourism-related purposes; 67.5% of local people believe that tourists would visit their village
in the absence of bull jumping and evangadi dance. Informant and deductive analysis shows tourism is a factor for the continuation and practice of whipping in the Hamer community.
Localized growth of carbon nanotubes via lithographic fabrication of metallic deposits
Authors: Tu Fan , Drost Martin , Szenti Imre , Kiss Janos , Kónya Zoltan , Marbach Hubertus
Published: December 2017

We report on the fabrication of carbon nanotubes (CNTs) at predefined positions and controlled morphology, for example, as individual nanotubes or as CNT forests. Electron beam induced deposition (EBID) with subsequent autocatalytic growth (AG) was applied to lithographically produce catalytically active seeds for the localized growth of CNTs via chemical vapor deposition (CVD). With the precursor Fe(CO)5 we were able to fabricate clean iron deposits via EBID and AG. After the proof-of-principle that these Fe deposits indeed act as seeds for the growth of CNTs, the influence of significant EBID/AG parameters on the deposit shape and finally the yield and morphology of the grown CNTs was investigated in detail. Based on these results, the parameters could be optimized such that EBID point matrixes (6 × 6) were fabricated on a silica surface whereby at each predefined site only one CNT was produced. Furthermore, the localized fabrication of CNT forests was targeted and successfully achieved on an Al2O3 layer on a silicon sample. A peculiar lift-up of the Fe seed structures as “flakes” was observed and the mechanism was discussed. Finally, a proof-of-principle was presented showing that EBID deposits from the precursor Co(CO)3NO are also very effective catalysts for the CNT growth. Even though the metal content (Co) of the latter is reduced in comparison to the Fe deposits, effective CNT growth was observed for the Co-containing deposits at lower CVD temperatures than for the corresponding Fe deposits.
SN 1986J VLBI. IV. The Nature of the Central Component
Authors: Bietenholz Michael F. , Bartel Norbert
Published: December 2017

We report on Very Large Array measurements between 1 and 45 GHz of the evolving radio spectral energy distribution (SED) of SN 1986J, made in conjunction with very long baseline interferometry (VLBI) imaging. The SED of SN 1986J is unique among supernovae, and shows an inversion point and a high-frequency turnover. Both are due to the central component seen in the VLBI images, and both are progressing downward in frequency with time. The optically thin spectral index of the central component is almost the same as that of the shell. We fit a simple model to the evolving SED consisting of an optically thin shell and a partly absorbed central component. The evolution of the SED is consistent with that of a homologously expanding system. Both components are fading, but the shell is fading more rapidly. We conclude that the central component is physically inside the expanding shell, and not a surface hotspot central only in projection. Our observations are consistent with the central component being due to interaction of the shock with the dense and highly structured circumstellar medium that resulted from a period of common-envelope evolution of the progenitor. However, a young pulsar-wind nebula or emission from an accreting black hole can also not be ruled out at this point.
Contribution of Field Strength Gradients to the Net Vertical Current of Active Regions
Authors: Vemareddy P.
Published: December 2017

We examined the contribution of field strength gradients for the degree of net vertical current (NVC) neutralization in active regions (ARs). We used photospheric vector magnetic field observations of AR 11158 obtained by Helioseismic and Magnetic Imager on board SDO and Hinode. The vertical component of the electric current is decomposed into twist and shear terms. The NVC exhibits systematic evolution owing to the presence of the sheared polarity inversion line between rotating and shearing magnetic regions. We found that the sign of shear current distribution is opposite in dominant pixels (60%–65%) to that of twist current distribution, and its time profile bears no systematic trend. This result indicates that the gradient of magnetic field strength contributes to an opposite signed, though smaller in magnitude, current to that contributed by the magnetic field direction in the vertical component of the current. Consequently, the net value of the shear current is negative in both polarity regions, which when added to the net twist current reduces the direct current value in the north (B

z
> 0) polarity, resulting in a higher degree of NVC neutralization. We conjecture that the observed opposite signs of shear and twist currents are an indication, according to Parker, that the direct volume currents of flux tubes are canceled by their return currents, which are contributed by field strength gradients. Furthermore, with the increase of spatial resolution, we found higher values of twist, shear current distributions. However, the resolution effect is more useful in resolving the field strength gradients, and therefore suggests more contribution from shear current for the degree of NVC neutralization.
On the Dependence of the X-Ray Burst Rate on Accretion and Spin Rate
Authors: Cavecchi Yuri , Watts Anna L. , Galloway Duncan K.
Published: December 2017

Nuclear burning and its dependence on the mass accretion rate are fundamental ingredients for describing the complicated observational phenomenology of neutron stars (NSs) in binary systems. Motivated by high-quality burst rate data emerging from large statistical studies, we report general calculations relating the bursting rate to the mass accretion rate and NS rotation frequency. In this first work, we ignore general relativistic effects and accretion topology, although we discuss where their inclusion should play a role. The relations we derive are suitable for different burning regimes and provide a direct link between parameters predicted by theory and what is to be expected in observations. We illustrate this for analytical relations of different unstable burning regimes that operate on the surface of an accreting NS. We also use the observed behavior of the burst rate to suggest new constraints on burning parameters. We are able to provide an explanation for the long-standing problem of the observed decrease of the burst rate with increasing mass accretion that follows naturally from these calculations: when the accretion rate crosses a certain threshold, ignition moves away from its initially preferred site, and this can cause a net reduction of the burst rate due to the effects of local conditions that set local differences in both the burst rate and stabilization criteria. We show under which conditions this can happen even if locally the burst rate keeps increasing with accretion.
BAT AGN Spectroscopic Survey. V. X-Ray Properties of the Swift/BAT 70-month AGN Catalog
Authors: Ricci C. , Trakhtenbrot B. , Koss M. J. , Ueda Y. , Del Vecchio I. , Treister E. , Schawinski K. , Paltani S. , Oh K. , Lamperti I. , Berney S. , Gandhi P. , Ichikawa K. , Bauer F. E. , Ho L. C. , Asmus D. , Beckmann V. , Soldi S. , Baloković M. , Gehrels N. , Markwardt C. B.
Published: December 2017

Hard X-ray (≥10 keV) observations of active galactic nuclei (AGNs) can shed light on some of the most obscured episodes of accretion onto supermassive black holes. The 70-month Swift/BAT all-sky survey, which probes the 14–195 keV energy range, has currently detected 838 AGNs. We report here on the broadband X-ray (0.3–150 keV) characteristics of these AGNs, obtained by combining XMM-Newton, Swift/XRT, ASCA, Chandra, and Suzaku observations in the soft X-ray band (

keV) with 70-month averaged Swift/BAT data. The nonblazar AGNs of our sample are almost equally divided into unobscured (

) and obscured (

) AGNs, and their Swift/BAT continuum is systematically steeper than the 0.3–10 keV emission, which suggests that the presence of a high-energy cutoff is almost ubiquitous. We discuss the main X-ray spectral parameters obtained, such as the photon index, the reflection parameter, the energy of the cutoff, neutral and ionized absorbers, and the soft excess for both obscured and unobscured AGNs.
The Brightest Known H2CO Maser in the Milky Way: G339.88-1.26
Authors: Chen Xi , Shen Zhi-Qiang , Ellingsen Simon P. , Li Xiao-Qiong , Yang Kai , Chen Hong-Ying , Dong Jian
Published: December 2017

We report the detection of the strongest

6 cm H2CO emission in our Galaxy. The detection toward the massive star-forming region G339.88-1.26 was made using the Shanghai Tianma radio telescope (TMRT). The G339.88-1.26 star formation region hosts one of the strongest 6.7 GHz methanol masers and has an accompanying collimated, ionized jet seen in radio continuum free–free emission. The peak flux density of the detected H2CO emission is ∼19 Jy, one order of magnitude stronger than the nine previously known H2CO maser sources. The corresponding luminosity is also brighter than has been observed in previous H2CO maser sources, even those detected in the Central Molecular Zone of our Galaxy. A TMRT on-the-fly map of the region shows a point-like source structure and this, combined with the spectral characteristics of the H2CO emission (multiple, narrow components), leads us to conclude that the detected H2CO emission is masing (with a brightness temperature in excess of 104 K). The detection of a very strong H2CO maser in G339.88-1.26 suggests that ionized jet/outflow environments might provide efficient maser pumping for this transition, with the ionized jet/outflow-driven shock causing collisional excitation, and are also able to provide additional seed photons for maser amplification of the radio continuum emission.
A Study of External Magnetic Reconnection that Triggers a Solar Eruption
Authors: Zhou G. P. , Zhang J. , Wang J. X. , Wheatland M. S.
Published: December 2017

External magnetic reconnection (EMR) is suggested to play an essential role in triggering a solar eruption, but is rarely directly observed. Here, we report on a filament eruption on 2014 October 3 that apparently involves the process of an early EMR. A total of 1.7 × 1020 Mx flux was first canceled along the filament-related polarity inversion line over 12 hr, and then the filament axis started to brighten in extreme ultraviolet (EUV). An impulsive EUV brightening began 30 minutes later, and we attribute this to EMR, as it is located at the center of a bidirectional outflow with a velocity of 60–75 km s−1 along large-scale magnetic loops from active regions NOAA 12178 and 12179, respectively, and over the filament mentioned above. Following the EMR, the filament was activated; then, partial eruption occurred 6 minutes later in the west, in which the decay index above the magnetic flux rope (MFR) reached the critical value of 1.5. The observations are interpreted in terms of underlying magnetic flux cancelation leading to the buildup and eventual formation of the MFR with a filament embedded in it, and the MFR is elevated later. The activated MFR rises and pushes the overlying sheared field and forms a current sheet causing the EMR. The EMR in turn weakens the constraining effect of the overlying field, leading to the arising of the MFR, and subsequently erupting due to torus instability.
Internet-Generation Nursing Students' View of Technology-Based Health Care
Authors: van Houwelingen Cornelis T.M. , Ettema Roelof G.A. , Kort Helianthe S.M. , ten Cate Olle
Published: December 2017

Background:

Today's nursing school applicants are considered “digital natives.” This study investigated students' views of new health care technologies.

Method:

In a cross-sectional survey among first-year nursing students, 23 common nursing activities and five telehealth nursing activities were presented along with three statements: “I consider this a core task of nursing,” “I look forward to becoming trained in this task,” and “I think I will do very well in performing this task.”

Results:

Internet-generation nursing students (
n
= 1,113) reported a significantly (
p
⩽ .001) less positive view of telehealth activities than of common nursing activities. Median differences were 0.7 (effect size [ES], −0.54), 0.4 (ES, −0.48), and 0.3 (ES, −0.39), measured on a 7-point scale.

Conclusion:

Internet-generation nursing students do not naturally have a positive view of technology-based health care provision. The results emphasize that adequate technology and telehealth education is still needed for nursing students. [
J Nurs Educ.
2017;56(12):717–724.]
Native European branchiobdellids on non-native crayfishes: Report from the Czech Republic
Authors: Bláha Martin , Ložek Filip , Buřič Miloš , Kouba Antonín , Kozák Pavel
Published: December 2017

Invasive alien species present a global threat to biodiversity, particularly where pathogens and symbionts are involved. Non-native crayfish species can increase their impact on the host ecosystem through introductions of symbiotic fauna. Conversely, non-native crayfishes could serve as hosts for native epibionts, thus substituting for disappearing native crayfishes as well. Here we report the presence of native branchiobdellids on naturalized populations of non-native crayfish Orconectes limosus and Pacifastacus leniusculus living in sympatry with native Astacus astacus. The native crayfish species probably served as a source of Branchiobdella spp. for non-native crayfishes. Two species of Branchiobdella (B. parasita and B. pentadonta) were found on P. leniusculus while only B. parasita was found on O. limosus. The level of colonization of inspected specimens and species was also evaluated. The mean number of branchiobdellids found on P. leniusculus and O. limosus was 26.0±15.9, and 64.8±27.7, respectively. Orconectes limosus was more heavily colonized by Branchiobdella despite being significantly smaller than P. leniusculus. Non-native species were corroborated as suitable to host the native epibionts.
Indicator mineral signature of the Strange Lake rare earth element deposit, Quebec and Newfoundland and Labrador
Authors: McClenaghan M B , Paulen R C , Kjarsgaard I
M , Averill S A , Fortin R
Published: December 2017

The first detailed study of the indicator mineral signature of a major rare earth element (REE) deposit in glaciated terrain was undertaken at the Strange Lake Zr-Y-HREE deposit in northern Quebec and Newfoundland and Labrador, Canada. The heavy mineral
(>3.2 SG) and mid-density (3.0-3.2 SG) nonferromagnetic fractions of bedrock samples from the two mineralized zones were examined to determine potential indicator minerals of REE mineralization. Till samples overlying and up to 50 km down-ice of the deposit were examined to determine the
abundance of these minerals at varying distances from the deposit. The deposit contains numerous oxide, silicate, phosphate, and carbonate indicator minerals. Some of the minerals observed in both the bedrock and till samples had not been previously reported for the Strange Lake deposit. The most
useful indicator minerals were determined to be Zr-silicates (primary elpidite, secondary gittinsite, and many other hydrated Zr±Y±Ca-silicate minerals), pyrochlore, thorite/ thorianite, monazite/rhabdophane, chevkinite, parisite, bastnaesite, kainosite, and allanite. Rare earth element
indicator minerals can now be added to the expanding list of indicator minerals that can be used to explore for a broad range of deposit types and commodities, i.e., diamonds, precious metals, base metals, and strategic metals.