bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Analysis of the Expression, Prognostic Value, and Relationship with Immune Infiltration of CMTMs in Human Hepatocellular Carcinoma
Authors: jiang shitao , Zhang Junwei , Liu Yaoge , Zhang Ting , Zhang Lei , Xu Yiyao , Zhao Haitao , Sang Xinting , Lu Xin
Published: September 2021

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family refers to an updated gene family involved in diverse pathophysiological processes. However, the effect exerted by CMTM family members (CMTMs) in hepatocellular carcinoma (HCC) is still elusive. Herein, to elucidate the expression, prognostic value, and immune roles of CMTMs in HCC, a comprehensive bioinformatic analysis was carried out. Our findings showed that CKLF, CMTM1, CMTM3-4, and CMTM7-8 displayed higher mRNA expression levels in HCC tissues than in normal tissues, yet CMTM2, CMTM5, and CMTM6 were lower in HCC tissues. The levels of CMTM1, CMTM2, and CMTM4 were related to tumor stage. Survival analysis showed that high levels of CKLF, CMTM1, CMTM4, and CMTM6-7 were associated with shorter overall survival (OS). Conversely, a high level of CMTM5 in HCC patients was associated with improved OS. We also found that CKLF, CMTM1-4, and CMTM6-7 were closely correlated with immune infiltration in the HCC microenvironment. In conclusion, this study indicates that CMTMs exert a crucial effect on HCC microenvironment remodeling. CKLF, CMTM1, CMTM4, and CMTM6-7 are potential targets of precision therapy, and CMTM5 is a tumor-suppressive gene that was associated with improved survival in HCC patients.
Active Monitoring of Selective Laser Melting Process by Training an Artificial Neural Net Classifier on Layer-By-Layer Surface Laser Profilometry Data
Authors: Terry Benjamin S. , Baucher Brandon , Chaudhary Anil , Chakraborty Subhadeep
Published: September 2021

This paper reports some recent results related to active monitoring of Selective Laser Melting (SLM) processes through analysis of layer-by-layer surface profile data. Estimation of fault probability was carried out experimentally in a Renishaw AM250 machine, by collecting Fe3Si powder bed height data, in-situ, during the metal additive manufacturing of a Heat Exchanger section, comprised of a series of conformal channels. Specifically, high-resolution powder bed surface height data from a laser profilometer was linked to post-print ground-truth labels (faulty or nominal) for each site from CT scans, by training a shallow artificial neural net (ANN). The ANN demonstrated interesting capabilities for discovering correlations between surface roughness characteristics and the presence and size of faults. Strong performance was achieved with respect to several standard metrics for classifying faulty and nominal sites. These developments can potentially enable active monitoring processes to become a future component of a layer-by-layer feedback system for better control of SLM processes.
Integrated 2D graphene oxide layered films for enhanced nonlinear optics in high index doped silica waveguides
Authors: Moss David
Published: September 2021

We demonstrate enhanced four-wave mixing (FWM) in doped silica waveguides integrated with graphene oxide (GO) layers. Owing to strong mode overlap between the integrated waveguides and GO films that have a high Kerr nonlinearity and low loss, the FWM efficiency of the hybrid integrated waveguides is significantly improved. We perform FWM measurements for different pump powers, wavelength detuning, GO coating lengths, and number of GO layers. Our experimental results show good agreement with theory, achieving up to ~9.5-dB enhancement in the FWM conversion efficiency for a 1.5-cm-long waveguide integrated with 2 layers of GO. We show theoretically that for different waveguide geometries an enhancement in FWM efficiency of ~ 20 dB can be obtained in the doped silica waveguides, and more than 30 dB in silicon nanowires and slot waveguides. This demonstrates the effectiveness of introducing GO films into integrated photonic devices in order to enhance the performance of nonlinear optical processes.
Selected ‘Starter Kit’ energy system modelling data for Uruguay (#CCG)
Authors: Cannone Carla , Allington Lucy , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Rogner Holger , Quirós-Tortós Jairo , Angulo-Paniagua Jam
Published: September 2021

Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Uruguay, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Role of three bird species in the life cycle of two Sarcocystis species (Apicomplexa, Sarcocystidae) in the Czech Republic
Authors: Máca Ondřej , González David
Published: September 2021

BackgroundBirds are one of the groups involved in the development of Sarcocystis Lankester, 1882, serving either as intermediate or definitive hosts. The white-tailed sea eagle Haliaeetus albicilla (Linnaeus, 1758), red kite Milvus milvus (Linnaeus, 1758) (both Accipitriformes) and common starlings Sturnus vulgaris Linnaeus, 1758 (Passeriformes) were examined to elucidate their participation in the development of Sarcocystis, as well as to determine the specific identity of the parasites based on morphological and especially molecular analyses.MethodsIn 2020–2021, one white-tailed eagle, one red kite and five common starlings were parasitologically examined for the presence of Sarcocystis using flotation centrifugation coprological method and by wet mounts of intestinal mucosa scrapings and/or muscle samples. Positive samples were processed by light microscopy, histologically and followed molecularly at four genetic markers (18S rRNA, 28S rRNA, ITS1 and cox1).ResultsThe white-tailed eagle harboured oocysts/sporocysts of S. arctica Gjerde et Schulze, 2014 in the intestinal mucosa, while the intestinal mucosa of the red kite and breasts and leg muscles of one common starling were positive to S. halieti Gjerde, Vikøren et Hamnes, 2018. Sequences from eagle shared 99.6 − 100% identity with each other and S. arctica in the red fox (V. vulpes Linnaeus, 1758) from the Czech Republic. Sequences from the common starling and red kite shared 100% identity with each other and with S. halieti in the great cormorant (P. carbo [Linnaeus, 1758]) from Lithuania and H. albicilla from Norway.ConclusionsThe white-tailed sea eagle (H. albicilla) acts as natural definitive host of S. arctica, whereas the common starling (St. vulgaris) and red kite (M. milvus) represent intermediate and definitive hosts, respectively, for S. halieti.
Assessing the quality of complementary and alternative medicine website information for cancer: A cross-sectional review and analysis
Authors: Thakar Harmy , Balkaran Sabrina L. , Ng Jeremy Y.
Published: September 2021

Patients with cancer frequently utilize complementary and alternative medicine (CAM); prior to this, many seek information about these therapies online. Little is known about the quality of this web-based consumer health information (CHI). The present study aimed to address this paucity of research by evaluating the quality of websites containing information on CAM treatments for cancer. Six unique search terms were entered into Google across four English-speaking countries. The first 20 results of each search were assessed and included if they contained CAM consumer health information for the treatment and/or management of cancer. Eligible websites were assessed using the 16-item DISCERN instrument, designed to evaluate information quality. Of the 480 identified websites, 387 were duplicates, and 53 fit the eligibility criteria and were assessed using the DISCERN instrument. Mean summed DISCERN scores across all websites was 53.08 (SD = 12.75), and mean scores of the overall quality of each website was 3.22 (SD = 0.80). Website CHI quality on CAM therapies for cancer were generally acceptable. Several website quality issues were identified, including a lack of transparency surrounding references, areas of uncertainty, consequences of foregoing treatment, and treatment impacts on quality of life.
The risk for paediatric obstructive sleep apnoea in rural Queensland
Authors: Fischer Marguerite A. , Karadeniz Ersan I. , Flores-Mir Carlos , Lindsay Daniel , Karadeniz Carmen
Published: September 2021

Background

The importance of assessing patients for paediatric obstructive sleep apnoea (OSA) cannot be more highly stressed and orthodontists may play an essential role in risk screening. The Paediatric Sleep Questionnaire (PSQ) is a validated tool to identify whether a child is at risk for paediatric OSA.

Objectives

The likelihood of paediatric OSA in school-aged children residing in Far North Queensland (FNQ) will be assessed using the PSQ.

Methods

Parents of children aged between 4 and 18 years were invited to participate through schools and social media messaging to complete an online PSQ questionnaire to assess their OSA risk and demographics.

Results

The final sample consisted of 404 school-aged children of whom 62.5% were found to be at a high-risk for paediatric OSA. The high risk was significantly associated with males and those of overweight/obese BMI status (p < 0.001). Race and age were not significant associations (p > 0.05).

Conclusions

Within the contributing sample of school-aged children in FNQ, a significant number were found to be at high-risk of paediatric OSA. Males and overweight/obese children were measured risk factors.
PANDEMIA DA COVID-19: PROSPECÇÃO BIBLIOMÉTRICA E PATENTÁRIA DE VENTILADORES MECÂNICOS ALTERNATIVOS DE BAIXO CUSTO
Authors: Schultz-Macedo Daiane , Lomanto Bastos Grazielle , Ferreira Lima Angela Maria
Published: September 2021

O estudo tem por objetivo realizar uma prospecção bibliométrica e patentária de ventiladores mecânicos alternativos de baixo custo relacionados a doenças respiratórias como forma de enfrentamento à covid-19. Trata-se de uma pesquisa descritiva exploratória com abordagem quali-quantitativa, utilizando como técnicas de tratamento das informações as prospecções bibliométrica e patentária. As bases de dados utilizadas para o levantamento dos artigos foram Web of Science e Scopus e para o mapeamento de patentes o Orbit Intelligence e o Instituto Nacional de Propriedade Industrial. Ao todo foram analisados 15 artigos, sendo todos de código aberto, e 83 patentes. O país que mais publica artigos são os Estados Unidos, com 5, e a China a maior detentora de patentes, com 63. O Brasil apresenta-se com duas publicações de artigos, fruto de cooperações entre universidades, e cinco proteções de patentes. Pode-se concluir que nos últimos 5 anos houve um engajamento entre os países para o desenvolvimento de ventiladores alternativos de baixo custo e o aumento no desenvolvimento de pesquisas, por meio de artigos científicos, visando o rompimento de paradigmas em busca de novas tecnologias.

Palavras-chave: Covid-19; Ventiladores mecânicos; Baixo custo.
Modern Healthy Lifestyle Miskolc
Authors: Mató-Juhász Annamária
Published: September 2021

Mit is jelent a gyakorlatban a modern egészséges életstlus? Leginkább azt jelent, hogy van eszköztáram a stresszel megküzdeni, hogy önmagam tudjak lenni egy olyan világban, amely számtalanszor sok, zajos, nehéz, és talán még veszélyes is. Azt is jelent továbbá, hogy találok kapaszkodókat, amikor elhatalmasodik a bizonytalanság és a félelem bennem. A mostani tanulmány Miskolc példáján mutatja be azt az összefogást, amely újragondolja a jólléthez való viszonyt. Újragondolja a lakosság és a helyi szolgáltatók szemszögéből, és megkísérli az egészségturizmus megteremtését egy olyan helyen, ahol eddig máson volt a fókusz. A bemutatot mintaprojekt példaként szolgálhat más települések számára is.
Küzdj a szabadidődben/ért!? Küzdőjátékok alkalmazási lehetőségei a rekreációban
Authors: Dömők Ákos , Nagyváradi Katalin , Koszogovits Mihály
Published: September 2021

A tanulmány célja, hogy a küzdősportok, küzdőjátékok rekreációs lehetőségére hívja fel a fgyelmet. A cikk foglalkozik a küzdősportok, harcművészetek fzikai és szellemi rekreációban betöltöt szerepével. A szerzők célja a küzdősport játékokat tartalmazó gyakorlatgyűjteménnyel útmutatást adni a szabadidő aktv eltöltéséhez. Az összegyűjtöt gyakorlatok játékos formában tartalmazzák az ökölvívás, a birkózás és a judo elemeit. A gyakorlatok minden korosztály számára ajánlhatók eszköz vagy speciális felszerelés nélkül is. A tanulmány további célja, hogy a küzdőjátékok által népszerűsítse a küzdősportokat, mint rekreációs tevékenységeket.
Film és rekreáció 1. – A pandémia árnyékában
Authors: Magyar Márton
Published: September 2021

A Covid19 járvány miat lezárásoknak és szabályozásoknak köszönhetően az életünk minden téren gyökeresen átalakult. Olyan szabadidős tevékenységeink, mint a flmszínházba járás, hónapokon át ellehetetlenült. A cikk betekintést ad az online szolgáltatók szférájába is, amely a multszerkezetű 21. századi flmpiac egyik szegmense, egy új (megerősödöt?) flmnézési színtérként.
Rekreációs ökölvívók attitűdjei
Authors: Gál Konrád , Bóka Ferenc
Published: September 2021

A küzdősportok egyik legnépszerűbb ágazata az ökölvívás. A jótékony hatásairól már több kutatásban utaltak, azonban kevesen foglalkoztak rekreációs irányzatával. Kutatásunk témájának választásában meghatározó szerepet játszot, hogy versenyszerűen bokszoltam. A kutatás eredményei várhatóan választ adnak arra, hogy az ökölvívás hogyan hat az egyén test, lelki egészségére, önbizalmára, stressztűrő képességére. Kíváncsiak voltunk arra is, hogy milyen pozitv, esetleg negatv hatással van a hétköznapi élet egyéb területeire? A kérdőívet összesen 302 fő töltöte ki. Az eredmények alapján elmondható, hogy a rekreációs boksz a testsúlyproblémákra sokaknak megoldásként szolgált, és a megkérdezetek többségénél az önbizalomra is jótékony hatással volt. Szintén kedvezően hatot a stressz kezelésére, és emellet a válaszadók közérzete is jobb let. A társas kapcsolatokra szintén előnyös hatással volt, hiszen a megkérdezetek új barátokra leltek, és a családi viszonyok szintjét is pozitvan generálta. Összességében elmondható, hogy kortól, nemtől és előképzetségtől függetlenül bárki megtalálja az örömét és kikapcsolódását e sportágban.
Product Differentiation Strategy and Perceived Financial Performance of Commercial Banks in Uganda: Moderating Effect of Managerial Discretion
Authors: Wambaka Kosea
Published: September 2021

The moderating effect of managerial discretion on the relationship between product differentiation strategy and firm financial performance has not received necessary empirical attention. The study sought to examine the moderating effect of managerial discretion on the relationship between product differentiation and the perceived financial performance of commercial banks in Uganda. A cross-section survey design was formulated targeting a population comprised of 210 Senior Managers and Chief Executives of 10 selected commercial banks in Uganda, which were chosen because of their relatively consistent superior financial performance in the last five years. A sample of 137 individuals was calculated using Yamane’s (1967) formula, and the technique of stratified proportionate random sampling was used in selecting sample subjects. Data was collected from these individuals using structured questionnaires and analyzed descriptively (using frequencies, percentages, means, and standard deviations) and inferentially using partial least squares structural equation modelling (PLS-SEM). The coefficient of the interaction term between managerial discretion and product differentiation strategy (MD*PD) was found positive and significant (β = 0.3421, ρ<0.05). Accordingly, the null hypothesis was rejected. It is concluded that managerial discretion is an important factor in the adoption of product differentiation strategies for purposes of enhancing the perceived financial performance of commercial banks in Uganda. The study recommends that commercial banks in Uganda should avail Chief Executives with the necessary and adequate latitude to implement product differentiation strategies if they are to maximize financial performance.
Evaluation of monitoring tools for WASH response in a cholera outbreak in northeast Nigeria
Authors: Ricau Marine , Lacan Lise , Ihemezue Emmanuel , Lantagne Daniele , String Gabrielle
Published: September 2021

Monitoring water, sanitation, and hygiene programs in cholera outbreaks is critical to improve humanitarian response. The objective of this research was to evaluate, and improve, WASH in cholera monitoring tools currently used in northeast Nigeria. We collected 723 forms from 2019 from three form types, combined them into one database of 980 activities, and stratified data by form type, response, implementing organization, activity, month/day, and geographical area. We conducted seven key informant interviews (KIIs) with monitoring tool users and decision-makers. Data irregularities (including in design, collection, and entry) led to an inability to meaningfully analyze monitoring forms. In KIIs, eight themes emerged: ease of use of current tools, improvement in monitoring over time, lack of access to data, need for training, inconsistent reporting practices, need for modification of current questions, need for the addition of new questions, and connectivity issues. Although informants reported monitoring helped organizations identify gaps during the response, the scarcity and inconsistency of the reported data make it difficult to draw any conclusions about program effectiveness, accountability in humanitarian response, or to make recommendations for improving programming. To improve monitoring, we recommend refining data collection by increasing the quantity of data reported, data consistency, and data relevancy.
Infancia y habilidades STEM: herramientas para su desarrollo
Authors: Bustamante Meza Lucia Yesenia , Salcedo Ospino Julieth Del Carmen , Torres Oliveros Silvia Andrea
Published: September 2021

Infancia y habilidades STEM: herramientas para su desarrollo es un libro de texto que contiene actividades lúdicas para que padres y docentes puedan acompañar a niños a partir de los 4 años en el mundo de la creación con tecnología y, en general, en la educación STEM. Las actividades están orientadas a desarrollar el pensamiento computacional, comprender el funcionamiento y la utilidad de máquinas simples, así como la robótica educativa, mediante el juego y la interacción. La simplicidad de conceptos, la didáctica empleada y la estructuración de cada una de las actividades permiten que padres de familia y docentes sean los principales receptores y que, mediante el trabajo colaborativo con niños y niñas, estos tengan la posibilidad de ser competentes en ciencia, tecnología, ingeniería y matemáticas desde temprana edad. Este texto es resultado del proyecto de investigación “Laboratorio Móvil para el desarrollo de habilidades STEM para egresadas y estudiantes de educación infantil de la universidad del Magdalena”, el cual fue financiado por el programa FRIDA (Fondo Regional para la Innovación Digital en América Latina y el Caribe) y la Universidad del Magdalena.
PREPARAÇÕES CULINÁRIAS ELABORADAS COM FARINHA DAS SEMENTES DE MELÃO CANTALOUPE: ESTUDO PILOTO
Authors: Priscilla dos Santos Miranda Mayara , Lopes de Lima Rosivania , Teixeira de Lima Oliveira Vanessa , Santana Luz Anna Beatriz
Published: September 2021

Introdução: O Brasil está no ranking dos 10 países que mais desperdiçam alimentos no mundo, é também o 3º maior produtor de frutas, sendo o Nordeste responsável pela produção de 95% do melão. Em consequência da elevada produção de frutas, o país tem enfrentado problemas ambientais decorrentes do lixo orgânico formado pelo desperdício. As cascas e sementes que são desprezadas, como exemplo do melão, podem ser utilizadas na alimentação por meio do aproveitamento integral de alimentos que tem sido uma ótima alternativa na busca de reduzir o desperdício, bem como enriquecer nutricionalmente as preparações culinárias. Objetivo: Realizar um estudo piloto para verificar características organolépticas de preparações culinárias elaboradas com farinha das sementes de melão cantaloupe (Cucumis melo L. var. reticulatus).  Metodologia: Foram elaborados 2 produtos, bolo simples e torta de frango, com diferentes percentuais de farinha das sementes de melão (FSM) adicionados à farinha de trigo enriquecida com ferro e ácido fólico, seguindo as concentrações de 25%, 50% e 75% de FSM. Resultados: As preparações feitas com farinha cuja constituição possuía 50% de FSM foram as comentadas na avaliação das características organolépticas, visto que eram mais palatáveis, em virtude da menor quantidade de resíduos, bem como apresentaram aroma e sabor mais agradáveis. Conclusões: Diante dos resultados observou-se que os participantes optaram pelos produtos que não possuíam grande quantidade de resíduos de melão nas preparações, visto que esses dificultam a mastigação e deglutição, bem como alteram algumas características organolépticas como aroma e sabor.
INVASÕES TERRITORIAIS POR PROCEDIMENTOS OBSTÉTRICOS EM UMA REGIÃO DE SAÚDE DO RIO GRANDE DO NORTE
Authors: Rodrigues Cardoso Gessica , Christiane de Azevedo Machado Flávia , Jennifer de Paiva Lins Deborah , Pinheiro de Lima Maria Clara
Published: September 2021

Introdução: No ponto de vista organizativo do Sistema Único de Saúde, a descentralização e a regionalização visam ampliar a resolutividade em nível local, reduzindo a desigualdade na assistência à saúde da população. Em meio às dificuldades de financiar os serviços dos três níveis de complexidades assistenciais em todos os municípios, opta-se pela formação de Regiões de Saúde (RS). No Rio Grande do Norte (RN), seus 167 municípios dividem-se em oito Regiões de Saúde. Objetivo: Identificar os procedimentos obstétricos e Estado que mais frequentemente ocasionou as invasões territoriais na assistência à saúde na VI região de saúde do Rio Grande do Norte em 2018. Metodologia: Estudo quantitativo, de caráter exploratório e descritivo realizado com dados secundários, referentes a 2018, captados no TABWIN, TabNet, CNES e banco de dados da programação pactuada e produção hospitalar cedido pela Secretaria Estadual de Saúde Pública do Rio Grande do Norte (SESAP). Resultados: Indicaram a existência da invasão territorial na região de saúde, Afirmando maior representatividade dessa invasão pelos Estados limítrofes. Conclusões: A invasão territorial se mostra presente na região de saúde e no Estado, despertando olhares sobre tal questão e suas implicações, potencializando novas inquietações.
COMPETÊNCIAS INTERPROFISSIONAIS PARA A GESTÃO DO CUIDADO ÀS CONDIÇÕES CRÔNICAS NA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: Sousa Jaciara , Mont’Alverne Napoleão Albuquerque Izabelle , Soares Lopes Vivia , De Sousa Cunha Luiz Guilherme , Oliveira do Nascimento Ana Beatriz , Cruz Farias Thiago Rodrigo
Published: September 2021

Introdução: A prática da gestão do cuidado em saúde vem sendo utilizada como uma estratégia para melhor organização dos serviços na perspectiva das redes de atenção à saúde com o intuito de garantir o cuidado integral aos usuários. Objetivo: Identificar na literatura atual quais as competências interprofissionais para a gestão do cuidado às condições crônicas na Atenção Primária à Saúde (APS). Metodologia: Trata-se de uma pesquisa descritiva de abordagem qualitativa do tipo revisão integrativa de literatura. A Coleta de dados foi realizada no período de Outubro a Dezembro de 2020 na qual buscou-se publicações brasileiras na base de dados Literatura Latino-Americano e do Caribe em Ciências da Saúde (LILACS) disponíveis na Biblioteca Virtual em Saúde (BVS). A amostra contou com a análise na íntegra de 12 artigos. Resultados: Dentre as competências interprofissionais observadas com relação à condição crônica pode-se citar a referência para os demais níveis de atenção garantindo a continuidade do cuidado, gestão dos casos, estímulo à autogestão e à autonomia, construção de um plano de cuidado integral, comunicação efetiva, capacitações para utilização de um modelo de atenção próprio às condições crônicas, informações sobre as condições do paciente, desenvolvimento de saberes compartilhados através da partilha de experiências, adoção de uma postura ética, de um bom vínculo entre profissional-usuário, operação competente do seu saber profissional, qualificação do sistema de apoio e criação de vínculo com a comunidade. Conclusões: As competências interprofissionais visualizam de uma maneira mais precisa a dimensão profissional da gestão do cuidado e pressupõem o compartilhamento de saberes para articulação da rede de atenção à saúde. Verifica-se que os profissionais da APS possuem maiores responsabilidades tendo em vista a sua posição de coordenadora do cuidado.
GALERIA ILUSTRADA DA CLASSIFICAÇÃO INTERNACIONAL DE FUNCIONALIDADE E INCAPACIDADE EM SAÚDE: RELATO DE EXPERIÊNCIA
Authors: Erivelton Medeiros Dias Danilo , Correia Campos Taynah , Luna da Silva Santos Ivanaldo , Dayse Gomes de Oliveira Julyenne , Souza Monteiro Karolinne
Published: September 2021

Introdução: A Síndrome Congênita do Zika (SCZ) constitui uma nova condição de saúde, advinda do surto do vírus Zika (ZIKV) no Brasil no início do ano 2015. É caracterizada por um conjunto de anormalidades que envolve a desproporção craniofacial, irritabilidade, espasticidade, convulsões, dificuldades alimentares, anormalidades oculares e perda auditiva. Objetivo: relatar a experiência do uso da Galeria Ilustrada da Classificação Internacional de Funcionalidade, Incapacidade e Saúde como auxílio para coleta de dados em pesquisa sobre funcionalidade e incapacidade em crianças com Síndrome congênita do Zika. Metodologia: estudo qualitativo do tipo relato de experiência. Resultados: Os cenários foram centros de reabilitação para Síndrome congênita do Zika de dois estados brasileiros, Rio Grande do Norte e Paraíba, no período de novembro 2018 a fevereiro de 2019. O uso da galeria ilustrada da Classificação Internacional de Funcionalidade, Incapacidade e Saúde permitiu aos participantes da pesquisa uma melhor compreensão dos conceitos. Conclusões: Ferramentas visuais envolvendo a galeria ilustrada podem ser utilizadas como auxílio na coleta de dados em pesquisas qualitativas que envolvem a Classificação Internacional de Funcionalidade, Incapacidade e Saúde. Texto do método.
AVALIAÇÃO DA MORTALIDADE POR DOENÇAS CARDIOVASCULARES NO BRASIL: UMA SÉRIE TEMPORAL DE 2015 A 2019
Authors: Cunha da Silva Pellense Márcia , Santos de Amorim Margareth , Samuel Oliveira Dantas Eder , Da Silva Costa Ketyllem Tayanne , Barbosa de Andrade F´abia
Published: September 2021

Introdução: As doenças crônicas não transmissíveis são as principais causas de morte no mundo. Entre essas, As Doenças Cardiovasculares são catalogadas como a principal causa. Objetivo: Avaliar a mortalidade das doenças cardiovasculares no Brasil, a partir da série temporal de 2015 a 2019. Metodologia: Trata-se de um estudo ecológico transversal de série temporal e descritivo sobre a mortalidade por Doenças Cardiovasculares no Brasil. Foram utilizados dados secundários, obtidos em abril de 2021, no Departamento de Informática do Sistema Único de Saúde (DATASUS), cuja série temporal compreendeu o período entre 2015 e 2019. Resultados e Discussão: As taxas de mortalidade por DCV, no Brasil, demonstram uma tendência de acréscimo no período de 2016, 2017, 2018 e 2019, resultado muito similar aos dados encontrados em outros estudos realizados no Brasil. Os maiores índices se encontram nas regiões Sudeste e Sul, seguidos da região Nordeste. Tratando-se dos óbitos, segundo a raça no período de 2015 a 2019, se observa que a maior proporção de óbitos ocorreu na raça branca por Aterosclerose (62,14%), seguidos da raça parda (28,38%) e da raça negra (5,87%). Se destacam no estudo os dados sobre a Febre Reumática Aguda e as Doenças Reumáticas Crônicas do Coração, cujo percentual atinge os maiores índices no ano de 2017, chegando a 63,54% na população feminina. Quando se analisa a Proporção de Óbitos, segundo Faixa Etária no período se observa um maior acometimento geral da população idosa. Conclusões: As Doenças Cardiovasculares têm se mostrado cada vez mais prevalentes, acarretando aumento do número de morbimortalidade no país. Os resultados apontam para a necessidade de aprofundamento da questão, tendo em vista que, embora as condições sejam muito semelhantes entre os municípios, as diferenças nos indicadores são expressivas.
Princípios à Filosofia da Informação
Authors: Ordonhes Ramon
Published: September 2021

As discussões e problemas que surgem a uma área em desenvolvimento, tal como se deu à Ciência da Informação, ensejam uma tarefa teórica “filosófica”, que se acomodaria, como dimensão fundamental deste campo de pesquisa, em debates cujas concepções e consequências discursivas escapam às formas com que se lidaria, cotidianamente, com o objeto de interesse da área e seus respectivos pressupostos. Nesse âmbito, visto como primordial, se colocariam em questão os alicerces e princípios que assegurariam o trabalho e a delimitação conceitual do objeto apreendido pela Ciência da Informação. Nesse sentido, o objetivo deste artigo é colocar em análise duas propostas nomeadamente filosóficas de fundamentação da Ciência da Informação. Especificamente, desenvolver-se-á um comparativo entre duas propostas teóricas quanto ao objeto da Ciência da Informação: uma ontológica e uma outra epistemológica. Esse quadro comparativo terá por base as posições de Floridi e Frohmann de uma filosofia da informação. Assim, guiando-se pelo método teórico-exploratório de investigação, a pesquisa concentrar-se numa revisão (qualitativa) de literatura cujo resultado visa uma contribuição teórica ao plano da pesquisa fundamental na área. As considerações orbitam, finalmente, o modus operandi que cada autor acaba empreendendo para esse tipo de projeto teórico, bem como a concepção de filosofia que motiva tais pesquisas.
Glipizide Combined with ANP Suppresses Breast Cancer Growth and Metastasis by Inhibiting Angiogenesis through VEGF/VEGFR2 Signaling
Authors: Mao Guanquan , Zheng Shuting , Li Jinlian , Liu Xiaohua , Zhou Qin , Cao Jinghua , Zhang Qianqian , Zheng Lingyun , Wang Lijing , Qi Cuiling
Published: September 2021

Background:

Breast cancer is one of the most common cancers worldwide among women, and angiogenesis
has an important effect on its growth and metastasis. Glipizide, which is a widely used drug for type 2 diabetes mellitus,
has been reported to inhibit tumor growth and metastasis by upregulating the expression of natriuretic peptide
receptor A (NPRA). Atrial natriuretic peptide (ANP), the receptor of NPRA, plays an important role in angiogenesis.
The purpose of this study was to explore the effect of glipizide combined with ANP on breast cancer growth and metastasis.

Methods:

This study aimed at investigating the effect of glipizide combined with ANP on breast cancer. Glipizide,
ANP, or glipizide combined with ANP was intraperitoneally injected into MMTV-PyMT mice. To explore whether the
anticancer efficacy of glipizide combined with ANP was correlated with angiogenesis, a tube formation assay was
performed.

Results:

Glipizide combined with ANP was found to inhibit breast cancer growth and metastasis in MMTV-PyMT
mice, which spontaneously develop breast cancer. Furthermore, the inhibitory effect of ANP combined with glipizide
was better than that of glipizide alone. ANP combined with glipizide significantly inhibited tube formation of human
umbilical vein endothelial cells (HUVECs) by suppressing vascular endothelial growth factor (VEGF)/VEGFR2 (vascular
endothelial growth factor receptor 2) signaling.

Conclusions:

These results demonstrate that glipizide combined with ANP has a greater potential than glipizide alone
to be repurposed as an effective agent for the treatment of breast cancer by targeting tumor-induced angiogenesis.
In Vivo Treatment Efficacy of Essential Oil Isolated from Seeds of Momordica charantia in Streptozotocin-Induced Diabetes Mellitus
Authors: Mariammal Berlin Grace Viswanathan , Devarajan David Wilson , Jerrin Ruselraj , Viswanathan Sundaram , Siddikuzzaman  , Gopal Rengaswamy
Published: September 2021

Background:

All parts of Momordica charantia L. have potential hypoglycemic properties in reversing the metabolic disorder of diabetes mellitus. However, there exists a need for preparing an effective and safer formulation of active phytochemicals. We have also reviewed and analyzed certain patents on such preparatory methods for Momordica charantia L. formulations.

Objective:

This study aimed to isolate essential oil from the seeds of Momordica charantia L., analyze its phytochemicals, and study their anti-diabetic effects.

Methods:

The essential oil was isolated by the hydrodistillation method and analyzed for phytochemicals by GC-MS. Furthermore, its acute toxicity was tested in rats. Anti-diabetic effects were evaluated in Streptozotocin-induced diabetic rats with 17.5 and 55 mg/kg b.wt of essential oil by evaluating blood glucose, serum lipid profile, liver glycogen, protein, and other serum markers such as ALT, AST, ALP, urea, and creatinine. The histologic changes in the liver, pancreas, and kidney were evaluated using Haematoxylin and Eosin staining.

Results :

The phytochemicals having hypoglycaemic and insulin induction potency were identified in the GC-MS analysis. A highly significant (p≤0.01; p≤0.001) reduction in blood glucose was observed from 17.5 mg/kg and 55 mg/kg essential oil treatments, respectively. Diabetes-associated metabolic alterations (p≤0.001) observed in diabetic control rats such as lipid profile, enzymes, glycogen, protein, urea, and creatinine were normalized upon treatment with essential oil. Moreover, the histologic changes in vital organs reversed in treated rats.

Conclusion:

The essential oil of Momordica charantia L. seed has promising potency to normalize the metabolic changes of type II diabetes mellitus.
Evaluation of learning memory activity of Unmad
Gaja Kesari Rasa II in Animal Models
Authors: Jain Amit P.
Published: September 2021

In recent era there is competition in each and every field, so there is lot of mental stress or mental
disorder seen. In modern medicine there are various drugs such as antipsychotic, antiepileptic, mood
stabilizer etc. which have certain adverse effect such as drowsiness, dizziness, memory loss etc. But
Ayurveda certainly has an answer, there are total 112 formulations mentioned in classical text for
physco neurological disorder i.e., Unmad and Apasmar, out of these there are total 25 herbo-mineral
formulations and Unmad Gaja Kesari Rasa II (UGK II) is one of them. Present study was done to
evaluate Learning memory effect of Unmad Gaja Kesari Rasa II a herbo-mineral compound. Cook’s and
widely model was used to evaluate learning memory activity. Total 30 wistar rats were classified into
5 groups each containing 6 rats. Human dose was extrapolated with extrapolating factor 0.018 and
drug dose was given to control I and II, standard, test x and 2x group, after that learning and
Relearning trails were given and avoidance, escape and no response was observed. It has been
established that UGK II (Rasa Kamdhenu i.e.; R.K Unmad Chikitsa/9-12) has effective role in learning
and memory activity.
Comparative clinical study of Nagradya Churna and
Bhunimbadya Churna in management of Grahani w.s.r. to
Irritable bowel syndrome
Authors: . Darshana , Singh Amitabh
Published: September 2021

Grahani Dosha is vitiation of Agni i.e. functional derangement of Grahani regarding production of
Pachaka Pitta (enzymes responsible for digestion) and also holding (Grahana) of Ama (food) for
digestion. Grahani in Ayurveda is called as Pittadhara kala which is the seat of Agni responsible for
digestion of food and situated above Nabhi. The part of small intestine and large intestine lying
between Amashaya and Pakwashaya should be considered as Grahani. This part is also described as
the sole site of Pitta. Various disorders of GI tract like irritable bowel syndrome (IBS) can be
considered under heading of Grahani Roga. Both the formulations Nagradya Churna and Bhunimbadya
churna are highly effective, promote appetite, digestion and remove Ama Dosha from the system by
increasing the power of Agni. Madhu is Yogabahi and it helps to initiate the absorption through
intestine properly. Total 40 patients of Grahani were registered and randomly divided into 2 groups for
clinical trial of 45days. Result of the study revealed that both the formulations produced significant
results in almost all cases barring a few patients who were suffering from longer period.
Pharmacognostic Study of Bhustrina (Cymbopogon
citratus Stapf.)
Authors: Pradeep Seema , MP Shivamanjunath
Published: September 2021

Background: The plant Cymbopogon citratus Stapf. commonly known as Lemon grass belongs to Poeceae family and is a native of tropical countries, especially in Southeast Asia. Various studies has been done on the plant to reveal its potential therapeutic effects. Methodology: The study deals with detailed study about Ayurvedic literature of Cymbopogon, macro morphology and microscopy of transverse section of the Cymbopogon leaves. Other parameters like physicochemical constants and phytochemical screening were studied using the standard protocol. Results: The study provides referential information for the correct identification and standardization of crude drug of Cymbopogon citratus Stapf.
A controlled clinical study to evaluate the efficacy of
Janu Basti and Asthi Shrinkhala in management of
Janusandhigata Vata w.s.r to Osteoarthritis
Authors: . Rakesh , G Gopala Krishna , P Sowmyashree U. , C. Umesh
Published: September 2021

Background : Sandhigata Vata is characterized by Shoola (pain), Shopha (swelling) and restricted
movement of affected joints. Osteoarthritis is characterized by inflammation of joints, marked by
progressive cartilage damage as a result of age related degenerative change or trauma. Sandhigata Vata
correlates with Osteoarthritis. Objectives - The present study was intended to evaluate and compare the
efficacy of Asthishrinkhala (Trial drug) and Glucosamine sulfate (Control drug) in Janusandhigatavata w.s.r
to Osteoarthritis. Materials and Method - 40 subjects diagnosed with Janusandhigatavata were randomly
assigned into two equal groups comprising of 20 subjects each. Subjects of Group A received Janubasti with
Mahavishagarbha Taila and Tab. Glucosamine sulfate 500mg 1 T.I.D after food and subjects of Group B
received Janubasti with Mahavishagarbha Taila and Tab. Asthishrinkhala 500mg 1 T.I.D after food for a
duration of 30 days. Observation and Results - In the present study, Asthishrinkhala and Glucosamine
sulfate both were beneficial in reducing the symptoms of Janu Sandhigata Vata. On comparison between the
groups, Glucosamine sulfate was more in beneficial in reducing the symptom of Janu Sandhigata Vata
compared to Asthishrinkhala. However there was a statistically non significant result between groups,
overall the subjects on glucosamine sulfate expressed greater benefit compared to Asthishrinkhala.
Conclusion - Both the drugs were beneficial in managing the symptoms of Sandigatavata, but overall the
subjects treated with glucosamine sulfate expressed greater benefits compared to subjects treated with
Asthishrinkhala.
A comparative study to analyze the effect of Kshara and
Sneha on Hypercholesterolemia - A Kriyatmak approach
Authors: Dhamale Jalindar , J. Varuni S.
Published: September 2021

Hypercholesterolemia is one of the leading high risk factors for various cardiovascular disorders. It has
become a serious life threatening causative factor for various lifestyle disorders. A different
therapeutic measure which needs to be adopted to cut down this risk factor is a major requirement in
the present scenario. Based on “Samanya Vishesha Siddhanta” and “Panchabhoutika Siddhanta”
Paneeyakshara should reduce the serum cholesterol level. Based on the concept of
“Hetuvipareetarthakari Upashaya” Sneha (Gogrita) should reduce the serum cholesterol level. Keeping
this in mind a study was conducted to analyse the effect of Goghrita and Kshara on
hypercholesterolemic patients. Out of the 50 patients recruited for the study 25 patients were advised
to take Yavakshara 1 gm twice a day after food with warm water for 7 days and 25 patients were
advised to take 20 ml of cow ghee (Goghrita) along with food for 7 days. Lipid Profile was checked on
first day of study, 8th day (after study period) and 21st day (to check the sustainability of the study).
The obtained data were analysed statistically using the ‘General Linear Model of Anova Test’. The
serum Cholesterol level in both the groups was reduced which was statistically significant. It was
found that both Kshara (Yavakshara) and Goghrita (cow ghee) are very effective in controlling the
total cholesterol level.
Role of Jaloukavacharana in acute pain management
of Amavata with respect to Rheumatoid Arthritis : A
pilot study
Authors: Yadahalli Santosh L. , Desai Ananta , BR Aishwarya Lakshmi
Published: September 2021

Amavata is one of the most challenging diseases caused by Ama combining with vitiated Vata Dosha.
The disease Amavata manifests where patient cries out of pain, severe stiffness, loss of appetite,
vague body ache and crippling deformity of joints, which make them bed ridden. Having several
features similar to Rheumatoid arthritis, Amavata is generally compared with it. Rheumatoid arthritis
(RA) is a long-term autoimmune disorder that primarily affects joints. Pain and stiffness often worsen
following rest. Pain medications, steroids, and NSAIDs are frequently used in contemporary science, to
treat the disease. Disease modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and
methotrexate, are also used to slow the progression of disease but these have their own side effects.
Jaloukavacharana described in Ayurveda plays a major role in reducing pain and swelling. Hence an
effort has been made in this present study to evaluate the efficacy of Jaloukavacharana in the acute
management of pain in Amavata. 10 subjects between 20-60yrs with classical symptoms of Amavata
were selected from IP section of SJIIM Hospital, Bengaluru. The assessment was done before the day
of initiation of treatment, after the treatment and on 8th day. Clinically patients found significant relief
in pain, swelling and range of movements after one sitting of Jaloukavacharana, hence it can be
concluded that Jaloukavacharana is effective in management of pain in acute phase of Amavata.
A study on standardization of Bindu Pramana in
Nasya Karma
Authors: B Nagalakshmi , KN Vinaykumar
Published: September 2021

Panchakarma is a unique system of medicine comprising of five specialised purificatory procedures,
the action of which is fruitful only if it is administered by giving due importance to Matra and Kala.
Matra, the concept of dose fixation is of utmost importance in the practice of Panchakarma in order to
get optimum therapeutic effect. Nasya Karma occupies a special place in the domain of Panchakarma
as it deals with the organ of high importance, the “Shiras”. In the Classics, there is description
regarding Bindu Pramana for the administration of Nasya Karma which varies from individual to
individual as it is to be measured for each and every individual by dipping the first two phalanges of
index finger in Sneha Dravya. But, the current practice of Nasya Karma is done by administering
Nasya Dravya in the form of drops rather than adopting the concept of Bindu Pramana. In this regard,
an observational study was conducted on 30 subjects as an attempt to standardize the concept of
Bindu Pramana and the results were documented in relation to age, gender, height, weight, BMI,
circumference and height of middle and distal phalanx of index finger.
Analytical study of modified Manashiladi Lepa into Ointment
Authors: Y Suresh , BK Prashanth , Rao S Ravi , D’Souza Zenica , MS Krishnamurthy
Published: September 2021

Lepa Kalpana is one amongst the external application used in Ayurveda. Manashiladi Lepa is a formulation explained in ‘Rasa Tantra Sara Va Siddha Prayoga Sangraha’ for the prevention of scar in the skin surface. The formulation contains Ghrita and Madhu which is to be mixed with the powder of the herbs told in the formulation. In the present scenario, the Lepa Kalpana is not liked by the patients themselves as it leaves behind residual marks on the skin surface and stains the cloth if it comes in contact with it. Hence a modified Lepa in the form of ointment which contains reduced amount of oiliness and good packing is accepted by all. Literary review done through various sources like books, journals and internet revealed that, no modification studies have been carried out on this formulation yet. The Lepa is modified into an ointment for its easy acceptability and usage. The formulation is tested for its analytical values and discussed in the article.
Combined effectiveness of Maharasnadi Kashaya with Shunti Churna and Matra Basti with Ksheerabala Taila in Janu Sandhigata Vata (Osteoarthritis Knee) : An open label, single arm clinical study
Authors: K Kiran , B Vasantha , Totad Muttappa
Published: September 2021

Sandhi Gata Vata is a clinical condition that comes under the heading of Vata Vyadhi where Prakupita Vata affects Sandhi and causes specific signs and symptoms. Lakshanas of Sandhi Gata Vata of Janu Sandhi resembles the signs and symptoms of osteoarthritis of knee. Osteoarthritis of the knee is more commonly found in women than men, and the prevalence increases dramatically with age. The major risk factors associated with osteoarthritis knee joint are old age, obesity, excessive usage of knee joint (occupational), which makes it an important cause of disability. A clinical study was conducted on 31 subjects by administering combination of Maharsnadi Kashaya with Shunti Churna and Matra Basti with Ksheerabala Taila and the results obtained were statistically analysed. Statistically significant reduction in Lakshanas of Janu Sandhi Gata Vata and WOMAC scores were noted.