bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher Adalimumab Trough Levels Are Associated with Histologic Remission and Mucosal Healing in Inflammatory Bowel Disease
Authors: Wong Rochelle , Qin Lihui , Pan Yushan , Mahtani Prerna , Longman Randy , Lukin Dana , Scherl Ellen , Battat Robert
Published: October 2023

(1) Many patients with inflammatory bowel disease (IBD) in endoscopic remission have persistent histologic activity, which is associated with worse outcomes. There are limited data on the association between adalimumab drug concentrations and histologic outcomes using validated histologic indices. We aimed to assess the relationship between adalimumab concentrations and the Robarts Histopathology Index (RHI). (2) Patients from a tertiary IBD center from 2013 to 2020 with serum adalimumab (ADA) trough concentrations measured during maintenance therapy (≥14 weeks) and a colonoscopy or flexible sigmoidoscopy with biopsies performed within 90 days of drug level were included. Blinded histologic scoring using the RHI was performed. Primary analysis assessed the relationship between adalimumab drug concentrations and histologic remission using receiver operating characteristic curve analysis. (3) In 36 patients (26 Crohn’s Disease, 9 ulcerative colitis, 1 indeterminate), median adalimumab concentrations were higher (17.3 ug/mL, 12.2–24.0) in patients with histologic remission compared to those without (10.3 ug/mL, 6.8–13.9, p = 0.008). The optimal ADA concentration identified using the Youden threshold was ≥16.3 ug/mL (sensitivity 70%, specificity 90%). Patients with ADA ≥ 16.3 ug/mL had higher histologic remission rates (78%) compared to lower ADA concentrations (14%, p= 0.002), as well as higher mucosal healing rates (86%) compared to lower levels (12%, p = 0.001). Symptoms correlated weakly and non-significantly with both histologic (RHI) scores (r = 0.25, p = 0.2) and adalimumab concentrations (r = 0.05, p = 0.8). (4) The current study demonstrated that higher serum adalimumab concentrations (≥16.3 ug/mL) are needed for histologic remission and mucosal healing assessed using the RHI.
PIPAC for Gastrointestinal Malignancies
Authors: Daniel Sara K. , Sun Beatrice J. , Lee Byrne
Published: October 2023

The peritoneum is a common site of metastases for gastrointestinal tumors that predicts a poor outcome. In addition to decreased survival, peritoneal metastases (PMs) can significantly impact quality of life from the resulting ascites and bowel obstructions. The peritoneum has been a target for regional therapies due to the unique properties of the blood–peritoneum barrier. Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) have become accepted treatments for limited-volume peritoneal disease in appendiceal, ovarian, and colorectal malignancies, but there are limitations. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) improves drug distribution and tissue penetration, allowing for a minimally invasive application for patients who are not CRS/HIPEC candidates based on high disease burden. PIPAC is an emerging treatment that may convert the patient to resectable disease, and may increase survival without major morbidity, as indicated by many small studies. In this review, we discuss the rationale and benefits of PIPAC, as well as sentinel papers describing its application for gastric, colorectal, appendiceal, and pancreatobiliary PMs. While no PIPAC device has yet met FDA approval, we discuss next steps needed to incorporate PIPAC into neoadjuvant/adjuvant treatment paradigms, as well as palliative settings. Data on active clinical trials using PIPAC are provided.
International Survey of the Tools Used for Assessment, Monitoring and Management of Home Mechanical Ventilation Patients
Authors: Chatwin Michelle , Hart Nicholas
Published: October 2023

Background: There are limited data reporting diagnostic practices, compared to clinical guidelines, for patients with chronic respiratory failure requiring home mechanical ventilation (HMV). There are no data detailing the current use of downloaded physiological monitoring data in day-to-day clinical practice during initiation and follow up of patients on HMV. This survey reports clinicians’ practices, with a specific focus on the clinical approaches employed to assess, monitor and manage HMV patients. Methods: A web-based international survey was open between 1 January and 31 March 2023. Results: In total, 114 clinicians responded; 84% of the clinicians downloaded the internal physiological ventilator data when initiating and maintaining HMV patients, and 99% of the clinicians followed up with patients within 3 months. Adherence, leak and the apnea-hypopnea index were the three highest rated items. Oxygen saturation was used to support a diagnosis of nocturnal hypoventilation and was preferred over measurements of carbon dioxide. Furthermore, 78% of the clinicians reviewed data for the assessment of patient ventilator asynchrony (PVA), although the confidence reported in identifying certain PVAs was reported as unconfident or extremely unconfident. Conclusions: This survey confirmed that clinical practice varies and often does not follow the current guidelines. Despite PVA being of clinical interest, its clinical relevance was not clear, and further research, education and training are required to improve clinical confidence.
Self-Administered Virtual Reality for Postsurgical Pain Management: A Qualitative Study of Hospital Patients’ Reported Experiences
Authors: Lier Elisabeth J. , Smits Merlijn L. M. , de Vries Marjan , van Goor Harry
Published: October 2023

Virtual Reality (VR) has been shown to effectively reduce pain in patients with various pain conditions. However, questions arise on the use of VR in multimodal postsurgical pain management. Optimizing VR for pain management requires an understanding of intervention- and context-specific factors, based on patients’ needs and expectations after major surgery. This substudy is part of a randomized controlled trial investigating the effects of three VR interventions as an add-on, self-administered treatment for postsurgical pain. Semi-structured interviews were conducted to evaluate VR effects, software, hardware, prescriptions, and factors affecting the implementation of VR. Experiences across interventions were compared to identify relevant factors for successful implementation. Patients benefitted from self-administered VR in postsurgical pain management in various aspects and without serious drawbacks. Participants preferred an intuitive, 3D, 360-degree VR device with a large choice of applications matching their interests. The preferred frequency and duration of VR use was 2–3 sessions a day for 10–15 min each. Adjusting the VR use to individuals’ needs and contexts was reported to be key for successful implementation, with attention paid to improving the awareness of VR as a non-pharmacological means of promoting postsurgical recovery among patients and healthcare professionals.
Different Prognostic Role of Soluble PD-L1 in the Course of Severe and Non-Severe COVID-19
Authors: Sabbatino Francesco , Pagliano Pasquale , Sellitto Carmine , Stefanelli Berenice , Corbi Graziamaria , Manzo Valentina , De Bellis Emanuela , Liguori Luigi , Salzano Francesco Antonio , Pepe Stefano , Filippelli Amelia , Conti Valeria
Published: October 2023

Understanding the link between COVID-19 and patient immune characteristics is crucial. We previously demonstrated that high levels of the soluble Programmed Death-Ligand1 (sPD-L1) at the beginning of the infection correlated with low lymphocyte number and high C-reactive protein (CRP), longer length of stay (LOS), and death. This study investigated whether sPD-L1 can be a prognosis biomarker during COVID-19. Severe and non-severe COVID-19 patients were enrolled at the University Hospital of Salerno. During hospitalization, at admission, and after 12–14 days, patients’ data were collected, and sPD-L1 levels were measured by enzyme-linked immunosorbent assay. The peripheral lymphocyte number negatively correlated with the time of negativization (p = 0.006), length of stay (LOS) (p = 0.032), and CRP (p = 0.004), while sPD-L1 positively correlated with LOS (p = 0.015). Patients with increased sPD-L1 and lymphocyte number showed a shorter LOS than those with decreased sPD-L1 and lymphocyte number (p = 0.038) and those with increased sPD-L1 and decreased lymphocyte number (p = 0.025). Moreover, patients with increased sPD-L1 and decreased CRP had a shorter LOS than those with increased sPD-L1 and CRP (p = 0.034) and those with decreased sPD-L1 and CRP (p = 0.048). In conclusion, while at an early phase of COVID-19, sPD-L1 promotes an immune escape, later, it might act to dampen an excessive immune response, proving its role in COVID-19 prognosis.
Analog System High-Level Synthesis for Energy-Efficient Reconfigurable Computing
Authors: Ige Afolabi , Yang Linhao , Yang Hang , Hasler Jennifer , Hao Cong
Published: October 2023

The design of analog computing systems requires significant human resources and domain expertise due to the lack of automation tools to enable these highly energy-efficient, high-performance computing nodes. This work presents the first automated tool flow from a high-level representation to a reconfigurable physical device. This tool begins with a high-level algorithmic description, utilizing either our custom Python framework or the XCOS GUI, to compile and optimize computations for integration into an Integrated Circuit (IC) design or a Field Programmable Analog Array (FPAA). An energy-efficient embedded speech classifier benchmark illustrates the tool demonstration, automatically generating GDSII layout or FPAA switch list targeting.
Prediction of Spatial Distribution of Soil Organic Carbon in Helan Farmland Based on Different Prediction Models
Authors: Zhang Yuhan , Wang Youqi , Bai Yiru , Zhang Ruiyuan , Liu Xu , Ma Xian
Published: October 2023

Soil organic carbon (SOC) is widely recognized as an essential indicator of the quality of arable soils and the health of ecosystems. In addition, an accurate understanding of the spatial distribution of soil organic carbon content for precision digital agriculture is important. In this study, the spatial distribution of organic carbon in topsoil was determined using four common machine learning methods, namely the back-propagation neural network model (BPNN), random forest algorithm model (RF), geographically weighted regression model (GWR), and ordinary Kriging interpolation method (OK), with Helan County as the study area. The prediction accuracies of the four different models were compared in conjunction with multiple sources of auxiliary variables. The prediction accuracies for the four models were BPNN (MRE = 0.066, RMSE = 0.257) > RF (MRE = 0.186, RMSE = 3.320) > GWR (MRE = 0.193, RMSE = 3.595) > OK (MRE = 0.198, RMSE = 4.248). Moreover, the spatial distribution trends for the SOC content predicted with the four different models were similar: high in the western area and low in the eastern area of the study region. The BPNN model better handled the nonlinear relationship between the SOC content and multisource auxiliary variables and presented finer information for spatial differentiation. These results provide an important theoretical basis and data support to explore the spatial distribution trend for SOC content.
Oral Bioavailability and Pharmacokinetics of Sildenafil Orally Disintegrating Tablets under Various Gastric pH Levels Following Administration of Omeprazole in Rats
Authors: Shih Chin-Yu , Chen Chao-Yi , Lin Hsien-Te , Liao Ying-Ju , Liang Yao-Jen
Published: October 2023

Sildenafil citrate, an oral drug used to treat erectile dysfunction, has low water solubility and oral bioavailability. The solubility is greatly influenced by the pH, changing from 37.25 mg/mL to 0.22 mg/mL with a change in pH from 1.2 to 8.0. This indicates that the absorption may decrease in patients who use drugs, such as proton pump inhibitors (PPIs), for gastroesophageal reflux disease. To improve the absorption of sildenafil citrate at various gastric pH levels, a sildenafil citrate orally disintegrating tablet (ODT), which has a rapid disintegration feature, was produced by a 3D printing technique. Our study investigated the pharmacokinetic parameters of the sildenafil citrate ODT in rats after oral administration and compared the absorption of the sildenafil citrate ODT and sildenafil citrate commercial tablet (RLD), with and without PPI treatment. The LC/MS/MS analysis of the plasma sildenafil concentration revealed that the area under curve from time 0 to infinity (AUC0–∞) of sildenafil in the sildenafil citrate ODT group was significantly higher than in the sildenafil citrate RLD group whether it was in combination with the PPI or not (274.8% and 144%, respectively; p < 0.05). The relative systemic bioavailability of sildenafil citrate RLD significantly decreased with the PPI, but that of sildenafil citrate ODT was not affected by the PPI. These results indicate that the relative systemic bioavailability of sildenafil citrate ODT was increased when it was prepared using the 3D printing technique and the absorption of this formulation was not affected by the PPI.
Effect of Dispersing Carbon Nanotube in Aqueous Solution by Poly-Carboxylic-Based Surfactants on Mechanical and Microstructural Properties as Cementitious Composites
Authors: Kim Won-Woo , Moon Jae-Heum , Lee Seung-Tae
Published: October 2023

The development of high-performance concrete using carbon nanotubes (CNTs), which is used in various industries owing to its excellent mechanical properties, has attracted much attention, leading to ongoing research in this area. However, when mixing CNTs into cement paste, there has been limited focus on the dispersibility, and, in most cases, aqueous dispersions of CNTs used in other industrial sectors are used. Because CNTs form the structures of bundles or aggregates owing to their high aspect ratio and van der Waals force between particles, the desired dispersibility cannot be obtained when mixing CNTs in powder form with other materials. Therefore, in this study, we examined the applicability of CNT aqueous dispersions using PC-based plasticizer used in concrete. Aqueous dispersions of CNT using PC-based surfactants are prepared and their properties are compared with those of a PVP-based aqueous dispersion. To analyze the mechanical properties, the compressive strength and flexural strength are measured on the 28th day. Then, the dispersibility and microstructure are analyzed using scanning electron microscopy image analysis, thermogravimetric analysis, and BET (Brunauer–Emmett–Teller) analysis. The analysis results show the enhancement of mechanical properties due to the mixing of the CNT dispersion, and the results confirm the applicability of the proposed CNT aqueous dispersions using PC-based surfactants.
Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization
Authors: Al-Zyoud Walid , Haddadin Dana , Hasan Sameer Ahmad , Jaradat Hussamaldeen , Kanoun Olfa
Published: October 2023

This review article dives into the complex world of biocompatibility testing: chemical, mechanical, and biological characterization, including many elements of biocompatibility, such as definitions, descriptive examples, and the practical settings. The focus extends to evaluating standard documents obtained from reliable organizations; with a particular focus on open-source information, including FDA-USA, ISO 10933 series, and TÜV SÜD. We found a significant gap in this field: biomaterial scientists and those involved in the realm of medical device development in general, and implants in particular, lack access to a tool that reorganizes the process of selecting the appropriate biocompatibility test for the implant being examined. This work progressed through two key phases that aimed to provide a solution to this gap. A straightforward “yes or no” flowchart was initially developed to guide biocompatibility testing decisions based on the previously accumulated information. Subsequently, the Python code was employed, generating a framework through targeted questions. This work reshapes biocompatibility evaluation, bridging theory and practical implementation. An integrated approach via a flowchart and the Python code empowers stakeholders to navigate biocompatibility testing effortlessly. To conclude, researchers are now better equipped for a safer, more effective implant development, propelling the field towards improved patient care and innovative progress.
Experimental Study of Amphibolite–Basalt (SiO2-AlO3-CaO-Fe2O3) Glasses for Glass-Ceramic Materials Production
Authors: Lubas Malgorzata , Zawada Anna , Jasinski Jaroslaw Jan , Nowak Adrian
Published: October 2023

The paper presents research on multicomponent glasses obtained from natural and secondary raw materials, i.e., basalt, amphibolite, and cullet. The raw materials were used as potential sets to produce mineral fibres or glass-ceramic materials. FTIR spectroscopy and XRD studies were carried out to identify the composition of the phase type in the glass sets. The results were supported by SEM-EDS microstructural studies of the obtained materials. The ability of the melts to crystallize and their basic properties required in producing mineral fibres, i.e., the hardness and the acidity modulus, were also determined. In the glass samples after the crystallization process, the spectroscopic studies revealed an increase in the half-width of the band at 1200–800 cm−1 and splitting at the values of about 870 cm−1 and 970 cm−1. These changes probably indicate the formation of pyroxene-type crystalline phases. Moreover, based on the XRD results, it was confirmed that the obtained materials were fully amorphous. After annealing at 800 °C for 2 h, the materials show a small proportion of crystalline phases. For the materials annealed at higher temperatures, clear peaks from the crystalline phases were represented mainly by pyroxenes. The proportion of crystalline phases in the samples was also found to rise with increasing temperature, and the hardness values for the basalt glasses and glasses after crystallization rose from 753 to 946 HV0.05. Such an effect positively affects the properties of the obtained glass-ceramic materials based on the proposed sets. However, in the case of mineral fibres, crystallization at early 2 h at 800 °C can be a disadvantageous feature from the point of view of their application because crystalline phases can lead to fibre damage after a short period of operation; this will be confirmed in this study.
Mechanical Research on Reinforced Concrete Materials
Authors: Wang Wei
Published: October 2023

Reinforced concrete (RC) is a commonly used construction material in civilian and military buildings due to its superior material characteristics compared to steel and timber (e [...]
Emulation Evaluation of Interior Beam–Column Connections in PC and RC Moment-Resisting Frames
Authors: Jo Min-Su , Kim Hyeong-Gook , Kim Dong-Hwan , Lee Yong-Jun , Han Sang-Pil , Kim Kil-Hee
Published: October 2023

Precast concrete (PC) structures have many advantages, but their use in the construction of middle- to high-rise buildings is limited. The construction of PC structures requires skills in various operations such as transportation, assembly, lifting, and structural soundness. In particular, regarding the seismic design of PC structures, it is necessary to clearly evaluate whether they have the same structural performance and usability as integral RC (cast-in-place) structures. In this paper, an experimental study was conducted to investigate whether PC members can achieve a seismic performance equivalent to that of RC members in beam–column joints, which are representative moment-resisting frames. The main variables are the two types of structural systems (intermediate and special moment-resisting frames) and the design flexural strength ratio of the columns and beams. The experimental and analytical results showed that the seismic performance of the PC specimens was equivalent to that of the RC specimens in terms of strength, stiffness, energy dissipation, and strain distribution, except for the specimen with splice sleeve bond failure of the column reinforcement (poor filling of the internal mortar). In addition, the I series satisfied the present emulation evaluation criteria for special moment-resisting frames of PC structures, confirming the possibility of applying intermediate moment-resisting frames.
Characterization of Silicate Glass/Mullite Composites Based on Coal Fly Ash Cenospheres as Effective Gas Separation Membranes
Authors: Fomenko Elena V. , Rogovenko Elena S. , Anshits Natalia N. , Solovyov Leonid A. , Anshits Alexander G.
Published: October 2023

Membrane technology is a promising method for gas separation. Due to its low energy consumption, environmental safety, and ease of operation, membrane separation has a distinct advantage over the cryogenic distillation conventionally used to capture light inert gases. For efficient gas recovery and purification, membrane materials should be highly selective, highly permeable, thermally stable, and low-cost. Currently, many studies are focused on the development of high-tech materials with specific properties using industrial waste. One of the promising waste products that can be recycled into membrane materials with improved microstructure is cenospheres—hollow aluminosilicate spherical particles that are formed in fly ash from coal combustion during power generation. For this purpose, based on narrow fractions of fly ash cenospheres containing single-ring and network structure globules, silicate glass/mullite composites were prepared, characterized, and tested for helium–neon mixture separation. The results indicate that the fragmented structure of the cenosphere shells with areas enriched in SiO2 without modifier oxides, formed due to the crystallization of defective phases of mullite, quartz, cristobalite, and anorthite, significantly facilitates the gas transport process. The permeability coefficients He and Ne exceed similar values for silicate glasses; the selectivity corresponds to a high level even at a high temperature: αHe/Ne—22 and 174 at 280 °C.
Efficient Recovery of Vanadium and Titanium from Domestic Titanomagnetite Concentrate Using Molten Salt Roasting and Water Leaching
Authors: Trinh Ha Bich , Kim Seunghyun , Lee Jaeryeong , Oh Seokhoon
Published: October 2023

The traditional roasting technique using sodium salts in vanadium production has been disadvantageous due to the large consumption of energy and the emission of harmful gases. A modified process using molten salt roasting and water leaching to extract vanadium and titanium from domestic titanomagnetite concentrate was investigated. The roasting process was performed under optimal conditions: the weight ratio between the sample and NaOH of 1:1, the temperature of 400 °C, and the experiment time 90 min, and the conversion of vanadium could be maximized to 90%. The optimization of water leaching (at 60 °C for 90 min with a pulp density of 0.05 g/mL) could extract 98% of the vanadium from the roasted products into the solution, leaving titanium and iron remaining in the residue. Further purification of vanadium and titanium using the precipitation/hydrolysis process followed by calcination obtained the final products V2O5 and TiO2 with high purities of 90% and 96%, respectively. A potential approach with modification of the roasting stage using NaOH was proposed, which was not only efficient to selectively extract the value metals from the titanomagnetite but also eco-friendly based on the reduction in energy consumption and emission of harmful gases.
Advanced Deep Learning Techniques for High-Quality Synthetic Thermal Image Generation
Authors: Pavez Vicente , Hermosilla Gabriel , Silva Manuel , Farias Gonzalo
Published: October 2023

In this paper, we introduce a cutting-edge system that leverages state-of-the-art deep learning methodologies to generate high-quality synthetic thermal face images. Our unique approach integrates a thermally fine-tuned Stable Diffusion Model with a Vision Transformer (ViT) classifier, augmented by a Prompt Designer and Prompt Database for precise image generation control. Through rigorous testing across various scenarios, the system demonstrates its capability in producing accurate and superior-quality thermal images. A key contribution of our work is the development of a synthetic thermal face image database, offering practical utility for training thermal detection models. The efficacy of our synthetic images was validated using a facial detection model, achieving results comparable to real thermal face images. Specifically, a detector fine-tuned with real thermal images achieved a 97% accuracy rate when tested with our synthetic images, while a detector trained exclusively on our synthetic data achieved an accuracy of 98%. This research marks a significant advancement in thermal image synthesis, paving the way for its broader application in diverse real-world scenarios.
Design of Polynomial Observer-Based Control of Fractional-Order Power Systems
Authors: Gassara Hamdi , Iben Ammar Imen , Ben Makhlouf Abdellatif , Mchiri Lassaad , Rhaima Mohamed
Published: October 2023

This research addresses the problem of globally stabilizing a distinct category of fractional-order power systems (F-OP) by employing an observer-based methodology. To address the inherent nonlinearity in these systems, we leverage a Takagi–Sugeno (TS) fuzzy model. The practical stability of the proposed system is systematically established through the application of a sum-of-squares (SOS) approach. To demonstrate the robustness and effectiveness of our approach, we conduct simulations of the power system using SOSTOOLS v3.00. Our study contributes to advancing the understanding of F-OP and provides a practical framework for their global stabilization.
Asymptotic Behavior for a Coupled Petrovsky–Petrovsky System with Infinite Memories
Authors: Saber Hicham , Ferhat Mohamed , Benaissa Cherif Amin , Blouhi Tayeb , Himadan Ahmed , Alraqad Tariq , Moumen Abdelkader
Published: October 2023

The main goal of this article is to obtain the existence of solutions for a nonlinear system of a coupled Petrovsky–Petrovsky system in the presence of infinite memories under minimal assumptions on the functions g1,g2 and φ1,φ2. Here, g1,g2 are relaxation functions and φ1,φ2 represent the sources. Also, a general decay rate for the associated energy is established. Our work is partly motivated by recent results, with a necessary modification imposed by the nature of our problem. In this work, we limit our results to studying the system in a bounded domain. The case of the entire domain Rn requires separate consideration. Of course, obtaining such a result will require not only serious technical work but also the use of new techniques and methods. In particular, one of the most significant points in achieving this goal is the use of the perturbed Lyapunov functionals combined with the multiplier method. To the best of our knowledge, there is no result addressing the linked Petrovsky–Petrovsky system in the presence of infinite memory, and we have overcome this lacune.
Treatment Benefit and Treatment Harm Rates with Nonignorable Missing Covariate, Endpoint, or Treatment
Authors: He Yi , Zheng Linzhi , Luo Peng
Published: October 2023

The average treatment effect is an important concept in causal inference. However, it fails to capture variation in response to treatment due to heterogeneity at many levels among patients in the target population. To study the heterogeneity in the treatment effect, researchers proposed the concepts of treatment benefit rate (TBR) and treatment harm rate (THR). Howerver, in practice, missing data often occurs in treatment, endpoints, and covariates. In these cases, the conditions given by them are not enough to identify treatment benefit rate. In this article, we address the problem of identifying the treatment benefit rate and treatment harm rate when treatment or endpoints or covariates are missing. Different types of missing data mechanisms are assumed, including several situations of nonignorable missingness. We prove that the treatment benefit rate and treatment harm rate are identifiable under very mild conditions, and then construct estimators based on methods of the EM algorithm. The performance of the proposed inference procedure is evaluated via simulation studies. Lastly, we illustrate our method by real data sets.
An Improved Bit-Flipping Algorithm of Successive Cancellation List Decoding for Polar Codes
Authors: Wang Desheng , Yin Jihang , Xu Yonggang , Yang Xuan , Xu Qiuwei , Hua Gang
Published: October 2023

Polar codes, as the coding scheme for the control channel in fifth-generation mobile communication technology (5G), have attracted widespread attention since their proposal. As a mainstream decoding algorithm for polar codes, the successive cancellation list (SCL) decoder usually improves the error correction performance by increasing the list size, but this method suffers from the problems of high decoding complexity. To address this problem, this paper proposes a layered-search bit-flipping (LS-SCLF) decoding algorithm based on SCL decoding. Firstly, a new flip-bit metric is proposed, which derives a formula to approximate the probability of an error occurring in an information bit. This formula introduces a perturbation parameter to improve the calculation accuracy. Secondly, a compromise scheme for determining the perturbation parameter is proposed. The scheme uses Monte Carlo simulation to determine an optimized parameter for the precise positioning of the first erroneous decoded bit under different decoding conditions. Finally, a layered search strategy is adopted to sequentially search the erroneous decoded bits from the low order to high order, which can correct up to multiple bits at the same time. Simulation results show that the proposed algorithm achieves improved error correction performance with a slight increase in decoding complexity compared to the generalized SCL-Flip (GSCLF) decoding algorithm. This algorithm also achieves a good balance between the error correction performance and decoding complexity.
UV/H2O2-Degraded Polysaccharides from Sargassum fusiforme: Purification, Structural Properties, and Anti-Inflammatory Activity
Authors: Chang Shiyuan , Chen Xiaoyong , Chen Yifan , You Lijun , Hileuskaya Kseniya
Published: October 2023

The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H2O2-degraded polysaccharides from Sargassum fusiforme. Results indicated that twofractions with different monosaccharide compositions and morphological characteristics, PT-0.25 (yield 39.5%) and PT-0.5 (yield 23.9%), were obtained. The average molecular weights of PT-0.25 and PT-0.5 were 14.52 kDa and 22.89 kDa, respectively. In addition, PT-0.5 exhibited better anti-inflammatory activity with a clear dose dependence. The mechanism was associated with the inhibition of LPS-activated Toll-like receptor 4-mediated inflammatory pathways in RAW264.7 cells. The results showed that PT-0.5 was a complex polysaccharide mainly composed of 4-Fucp, t-Manp, 6-Galp, t-Fucp, and 3,4-GlcAp. These results would provide theoretical support for studying the structural properties and biological activities of UV/H2O2-degraded polysaccharides.
Latest Update on Outer Membrane Vesicles and Their Role in Horizontal Gene Transfer: A Mini-Review
Authors: Marinacci Beatrice , Krzyżek Paweł , Pellegrini Benedetta , Turacchio Gabriele , Grande Rossella
Published: October 2023

Outer membrane vesicles (OMVs) are spherical, lipid-based nano-structures, which are released by Gram-negative bacteria in both in vitro and in vivo conditions. The size and composition of OMVs depend on not only the producer bacterial species but also cells belonging to the same strain. The mechanism of vesicles’ biogenesis has a key role in determining their cargo and the pattern of macromolecules exposed on their surface. Thus, the content of proteins, lipids, nucleic acids, and other biomolecules defines the properties of OMVs and their beneficial or harmful effects on human health. Many studies have provided evidence that OMVs can be involved in a plethora of biological processes, including cell-to-cell communication and bacteria–host interactions. Moreover, there is a growing body of literature supporting their role in horizontal gene transfer (HGT). During this process, OMVs can facilitate the spreading of genes involved in metabolic pathways, virulence, and antibiotic resistance, guaranteeing bacterial proliferation and survival. For this reason, a deeper understanding of this new mechanism of genetic transfer could improve the development of more efficient strategies to counteract infections sustained by Gram-negative bacteria. In line with this, the main aim of this mini-review is to summarize the latest evidence concerning the involvement of OMVs in HGT.
Prolonged Anesthesia Effects of Locally Administered Ropivacaine via Electrospun Poly(caprolactone) Fibrous Membranes
Authors: Wang Li , Chen Jiaming , Li Zicen , Guo Fei
Published: October 2023

Prolonged analgesia is important to safeguard the patient’s comfort and safety during and after surgery in clinical practice. To meet the demand for prolonged analgesia, medical professionals often resort to increasing drug frequency, which may lead to poor patient compliance and serious complications due to drug overdose. Therefore, it is of great interest to develop controlled-release drug delivery systems for local anesthetics, enabling slow and controlled drug release to prolong the analgesic effect and minimize systemic toxicity. In this study, we utilized an electrospinning technique to fabricate nonwoven poly(caprolactone) (PCL) fibrous membranes loaded with Ropivacaine and performed proof-of-principle experiments on both in vitro drug release tests and in vivo animal tests, to further prolong the analgesic effect of Ropivacaine and improve postoperative local pain management and chronic pain treatment. Material characterization and in vitro drug release studies confirmed the feasibility of the Ropivacaine-loaded PCL fibrous membranes for sustained release. The drug loading content and drug loading efficiency of Ropivacaine-loaded fibrous membrane are 8.7 ± 0.3 wt% and 96 ± 3 wt%, respectively. Evaluation in an animal model demonstrated prolonged anesthesia effects along with excellent biocompatibility and stability. At 72 h, the cumulative release accounted for approximately 50% of the drug loading content. This study offers novel approaches and strategies for clinical postoperative pain management and chronic pain treatment, while providing new insights and directions for the design of local anesthetic controlled-release delivery systems.
Detonation Spraying of Ni-Based Composite Coatings Reinforced by High-Entropy Intermetallic Particles
Authors: Moghaddam Ahmad Ostovari , Shaburova Nataliya , Naseri Majid , Latfulina Yulia , Samodurova Marina , Krymsky Valerii , Litvinyuk Ksenia , Trofimov Evgeny
Published: October 2023

Ni-based composite coatings reinforced by high-entropy intermetallic compounds (HEICs) were prepared by detonation spraying (DS) on low alloy steel substrates. To this end, first (Ti-Nb)(V-Cr-Ni-Fe) and Al3(TiZrNbCrHfTa) HEIC powders were fabricated by arc melting followed by ball milling. The as-milled HEIC powders were then employed as reinforcement particles to prepare Ni-7wt.% HEIC composite coatings. The average particle size of the (Ti-Nb)(V-Cr-Ni-Fe) and Al3(TiZrNbCrHfTa) HEIC powders were 18 and 35 µm, respectively, while the average particle size of the Ni powder was 56 µm. (Ti-Nb)(V-Cr-Ni-Fe) exhibited a single hexagonal C14 Laves phase in spite of Ti and Nb segregations. The XRD pattern of Al3(TiZrNbCrHfTa) indicated the presence of a tetragonal D022-type structure along with some minor CrTi and Cr5Al8 phases. The sprayed Ni-7wt.% FeNiCrV-TiNb and Ni-7wt.% Al3(TiZrNbCrHfTa) composite coatings retained crystal structures of the powder mixtures, suggesting proper thermal stability for both powders. The coatings exhibited a dense microstructure consisting of a lamellar microstructure with low porosity and sound bonding with the substrate. The microhardness of Ni-7wt.% FeNiCrV-TiNb (450 HV) was higher than that of Al3(TiZrNbCrHfTa) (338 HV), and it exhibited lower fluctuation than that of Ni-7wt.% Al3(TiZrNbCrHfTa). DS is an effective method to fabricate metal matrix composites reinforced by HEICs with a low level of porosity.
Nucleation Work on Curved Substrates
Authors: Kožíšek Zdeněk , Král Robert , Zemenová Petra
Published: October 2023

Nucleation is the initial phase transition process when nuclei of a new phase form within an undercooled or supersaturated parent phase under appropriate conditions. Nucleation most often occurs through a heterogeneous process on active centers on which the probability of nucleus formation is high. In general, the origin of active centers may be difficult to distinguish. In this work, we consider the formation of crystalline nuclei in a melt on various curved substrates. Knowledge of excess free energy plays a key role in understanding the process of formation of clusters and it is not easy to express this quantity in a considered system. Excess free energy is often approximated within the framework of capillarity approximation based on interfacial energy, which depends on interatomic interactions near the interface, as well as the misfit between melts, surface roughness, temperature, composition, etc., near the phase interface. The formation of nuclei requires overcoming a certain energy (nucleation) barrier that is a consequence of balancing the volume and the interfacial free energy. Knowing the nucleation barrier (W) is crucial for understanding this process, as nuclei predetermine the physical properties of a newly formed phase. W is typically expressed as a function of the nucleus radius; however, in nucleation kinetics, one needs to determine (W) as a function of the number of molecules forming the nucleus. We analyze nucleation work on various substrates (flat, convex, and concave) for crystallization from an aluminum melt to show that the formation of nuclei is the most probable on concave substrates. An analytical expression for W can be easily applied to other systems under consideration. We show that under the same conditions, the critical radius of nuclei is identical for various substrate, in contrast with the critical number of molecules forming a nucleus.
Improved Mechanical Properties of Biocompatible Zn-1.7%Mg and Zn1.7%Mg-0.2%Zr Alloys Deformed with High-Pressure Torsion
Authors: Martynenko Natalia , Anisimova Natalia , Tabachkova Natalia , Rybalchenko Georgy , Shchetinin Igor , Rybalchenko Olga , Shinkareva Maria , Prosvirnin Dmitry , Lukyanova Elena , Temralieva Diana , Koltygin Andrey , Kiselevskiy Mikhail , Dobatkin Sergey
Published: October 2023

The potential medical Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys strengthened using high-pressure torsion (HPT) were investigated in this work. HPT led to a significant refinement of the microstructure of both alloys with the formation of an ultrafine-grained structure (UFG). The average grain size after HPT was ~700–800 nm for both alloys. The formation of the UFG structure led to an increase in the ultimate tensile strength of up to 401 ± 16 and 482 ± 12 MPa for the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys, respectively. Additionally, a variation in ductility of the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys of up to 56.3 ± 16.9% and 4.4 ± 0.6%, respectively, was also observed, apparently due to textural changes. HPT led to a small increase in the degradation rate of the alloys after 1 day of incubation in the medium. However, an increase in the incubation period of up to 30 days slowed down the degradation process and leveled the difference between the initial and HPT-treated state of the alloys. HPT did not affect the cytotoxicity of the Zn-1.7%Mg-0.2%Zr alloy and contributed to the reduction of hemolysis. Thus, the processing of the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys using HPT accelerated their biodegradation without compromising their biocompatibility.
The Extraction of Copper from Chalcopyrite Concentrate with Hydrogen Peroxide in Sulfuric Acid Solution
Authors: Petrović Sanja J. , Bogdanović Grozdanka D. , Antonijević Milan M. , Vukčević Marija , Kovačević Renata
Published: October 2023

Research on chalcopyrite leaching represents a great challenge, given its importance as one of the most abundant copper minerals and its significant role in global copper extraction. This study aimed to evaluate the effects of different parameters on chalcopyrite leaching by hydrogen peroxide as a strong oxidizing reagent in sulfuric acid solution. A series of leaching tests were carried out to investigate the effect of the solid/liquid ratio, stirring speed, temperature, oxidant and acid concentrations, and lixiviant dosing method on copper extraction from chalcopyrite concentrate. The catalytic decomposition of hydrogen peroxide occurred in the investigated leaching system, as reflected in the obtained metal extraction values. Copper extraction was increased in the first 60 min of the reaction, after which it essentially ceased. The maximum final copper extraction of 64.5% was attained with 3.0 mol/L H2O2 in 3.0 mol/L H2SO4 at a temperature of 40 °C after 120 min of reaction. Due to the catalytic decomposition of hydrogen peroxide in the examined leaching system, the leaching experiment was performed with the periodic addition of lixiviant at specific time intervals as well. The dissolution process was described by the first-order kinetics equation with an apparent activation energy of ~39 kJ/mol. Finally, XRD and SEM-EDS analyses were used to characterize the leached residue, and the results showed that the formation of elemental sulfur on the chalcopyrite surface affected the dissolution process.
Latest Advancements in Next-Generation Semiconductors: Materials and Devices for Wide Bandgap and 2D Semiconductors
Authors: Wang Zeheng , Huang Jing-Kai
Published: October 2023

Semiconductor materials, devices, and systems have become indispensable pillars supporting the modern world, deeply ingrained in various facets of our daily lives [...]
Design of a Subretinal Injection Robot Based on the RCM Mechanism
Authors: Yan Chenyu , Liu Manyu , Shi Guohua , Fan Jinyu , Li Yunyao , Wu Sujian , Hu Jinyuan
Published: October 2023

This study presents an investigation focusing on the advancement of a robot designed for subretinal injections in the context of macular degeneration treatment. The technique of subretinal injection surgery stands as the most efficacious approach for the successful transplantation of stem cells into the retinal pigment epithelium layer. This particular procedure holds immense significance in advancing research and implementing therapeutic strategies involving retinal stem cell transplantation. The execution of artificial subretinal surgery poses considerable challenges which can be effectively addressed through the utilization of subretinal injection surgery robots. The development process involved a comprehensive modeling phase, integrating computer-aided design (CAD) and finite element analysis (FEA) techniques. These simulations facilitated iterative enhancements of the mechanical aspects pertaining to the robotic arm. Furthermore, MATLAB was employed to simulate and visualize the robot’s workspace, and independent verification was conducted to ascertain the range of motion for each degree of freedom.
Biochemical, Catabolic, and PGP Activity of Microbial Communities and Bacterial Strains from the Root Zone of Baccharis linearis in a Mediterranean Mine Tailing
Authors: Aponte Humberto , Sulbaran-Bracho Yoelvis , Mondaca Pedro , Vidal Catalina , Pérez Rodrigo , Meier Sebastián , Cornejo Pablo , Rojas Claudia
Published: October 2023

The management of mine tailings (MT) is commonly workload heavy, intrusive, and expensive. Phytostabilization offers a promising approach for MT management; however, it poses challenges due to the unfavorable physicochemical properties of these wastes. Nevertheless, native microorganisms capable of supporting plant growth and development could enhance the efficacy of phytostabilization. This study assesses the biological activity of microbial communities from the root zone of Baccharis linearis, which is naturally present in MT, in order to evaluate their biotechnological potential for phytostabilization. The root zone and bulk samples were collected from B. linearis plants located within a MT in the Mediterranean zone of Chile. Enzyme activities related to the cycling of C, N, and P were assessed. The community-level physiological profile was evaluated using the MicroRespTM system. Bacterial plant growth-promoting (PGP) traits and colony forming units (CFU) were evaluated through qualitative and microbiological methods, respectively. CFU, enzyme activities, and CLPP were higher in the root zone compared with the bulk samples. Five bacterial strains from the root zone exhibited PGP traits such as P solubilization and N acquisition, among others. The presence of microbial communities in the root zone of B. linearis with PGP traits suggests their potential to enhance the ecological management of MT through phytostabilization programs.
Possible Mechanisms of Lymphopenia in Severe Tuberculosis
Authors: Li Fei , Chen Dandan , Zeng Qingqing , Du Yunjie
Published: October 2023

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). In lymphopenia, T cells are typically characterized by progressive loss and a decrease in their count results. Lymphopenia can hinder immune responses and lead to systemic immunosuppression, which is strongly associated with mortality. Lymphopenia is a significant immunological abnormality in the majority of patients with severe and advanced TB, and its severity is linked to disease outcomes. However, the underlying mechanism remains unclear. Currently, the research on the pathogenesis of lymphopenia during M. tuberculosis infection mainly focuses on how it affects lymphocyte production, survival, or tissue redistribution. This includes impairing hematopoiesis, inhibiting T-cell proliferation, and inducing lymphocyte apoptosis. In this study, we have compiled the latest research on the possible mechanisms that may cause lymphopenia during M. tuberculosis infection. Lymphopenia may have serious consequences in severe TB patients. Additionally, we discuss in detail potential intervention strategies to prevent lymphopenia, which could help understand TB immunopathogenesis and achieve the goal of preventing and treating severe TB.
Coalbed Methane Enrichment Regularity and Model in the Xishanyao Formation in the Santanghu Basin, NW China
Authors: Li Xinning , Zhou Jiamin , Jiao Lixin , Sun Bin , Huang Yangyang , Huang Diefang , Zhang Junlang , Shao Longyi
Published: October 2023

The Santanghu Basin is a typical low-rank coal-bearing basin in northwest China, with abundant coalbed methane (CBM) resources. However, the understanding of the main controlling factors and reservoir formation models of CBM in low-rank coal is still insufficient, which has restricted the exploration and development of CBM in this region. In this paper, the CBM enrichment controlling factors and enrichment models are analyzed based on the aspects of sedimentary environment, reservoir characteristics, sealing conditions, and hydrogeological conditions after systematically analyzing the geological characteristics of coal measures. The research results indicate that the coal seams of the Xishanyao Formation in the Santanghu Basin are stably developed, with the main macerals being vitrinite and a lower degree of coalification belonging to low-rank coal; the highest content of CBM can reach 7.17 m3/t, and the methane is mainly composed of biogenic gas supplemented by thermogenic gas; the roof lithology of the coal seam is mainly mudstone and siltstone, with good sealing conditions. Finally, two enrichment modes of coalbed methane in slope zones are proposed, namely, the CBM enrichment in the slope zone and the CBM enrichment by fault-hydraulic plugging. The results of this study can serve as a guide for the exploration and development of the deep-buried coalbed methane in the low-rank coal areas.