bluuebunny/crossref_metadata_2025 huggingface dataset:
Centro de Experimentación y Difusión de Música Contemporánea (CEDM)
Authors:   , Venero Ugarte Ronald Edwin
Published: July 2021

La trascendencia de la música en el Perú va más allá del carácter estético que pueda adoptar por cada región en la que se genera. Su importancia recae en la capacidad de establecerse como un generador de identidad nacional y promotor industrial. En este contexto la experimentación musical y la difusión son dos aspectos que deben ser atendidos, comprendiendo la problemática actual de la industria musical en nuestro país. El Centro de Experimentación y Difusión de Música Contemporánea propone un emplazamiento estratégico para el desarrollo musical con importante riqueza paisajística dada su ubicación frente a un gran parque como es el “Campo de Marte” en el distrito de Jesús María en la ciudad de Lima, entorno que aporta favorablemente al desempeño de las actividades del usuario. Así también su relación directa con el Centro Cultural Sérvulo Gutiérrez enriquece el programa del proyecto. El proyecto por su parte dota de servicios al parque y a la comunidad. La investigación contempla marco teórico, proyectos referenciales, usuario, estudio del lugar, parámetros de diseño y programa arquitectónico; proponiendo así una solución programática y arquitectónica que pone en valor el producto artístico-cultural nacional, a sus autores, ejecutantes y promotores, atendiendo a su vez los requerimientos de una industria que potencia la identidad nacional y que contribuye con el desarrollo económico del país.
Sequential Monte Carlo Filters with Parameters Learning for Commodity Pricing Models
Authors: Infante Saba , Sánchez Luis , Hernández Aracelis , Marcano José
Published: July 2021

In this article, an estimation methodology based on the sequential Monte Carlo algorithm is proposed, thatjointly estimate the states and parameters, the relationship between the prices of futures contracts and the spot prices of primary products is determined, the evolution of prices and the volatility of the historical data of the primary market (Gold and Soybean) are analyzed. Two stochastic models for an estimate the states and parameters are considered, the parameters and states describe physical measure (associated with the price) and risk-neutral measure (associated with the markets to futures), the price dynamics in the short-term through the reversion to the mean and volatility are determined, while that in the long term through markets to futures. Other characteristics such as seasonal patterns, price spikes, market dependent volatilities, and non-seasonality can also be observed. In the methodology, a parameter learning algorithm is used, specifically, three algorithms are proposed, that is the sequential Monte Carlo estimation (SMC) for state space modelswith unknown parameters: the first method is considered a particle filter that is based on the sampling algorithm of sequential importance with resampling (SISR). The second implemented method is the Storvik algorithm [19], the states and parameters of the posterior distribution are estimated that have supported in low-dimensional spaces, a sufficient statistics from the sample of the filtered distribution is considered. The third method is (PLS) Carvalho’s Particle Learning and Smoothing algorithm [31]. The cash prices of the contracts with future delivery dates are analyzed. The results indicate postponement of payment, the future prices on different maturity dates with the spot price are highly correlated. Likewise, the contracts with a delivery date for the last periods of the year 2017, the spot price lower than the prices of the contracts with expiration date for 12 and 24 months is found, opposite occurs in the contracts with expiration date for 1 and 6 months.
Identification of Secondary Metabolites and Proximate Analysis of Golden Apple Snails (Pomacea canaliculata L.) Meat Extract
Authors: Pertiwi Meilisha Putri , Saputri Dina Dyah
Published: July 2021

The growth of golden apple snails is very rapid and causes losses of paddy production. Therefore snails are also called pest, especially agricultural pest. Control of golden apple snails can be done by physical hand sorting and then processed into animal feed. Based on research golden apple snails proven have good nutritional content. Efforts to use golden apples nails pets become useful things such as animal feed is a sustainable conservation. Therefore, this study aims to carry out secondary metabolites identification, proximate testing, and antioxidant content of golden apple snails as an initial reference for the basic ingredients of animal feed manufacturing. The method use is hand sorting of golden apple snails at the research location, then brought to the laboratory to carry out the process of secondary metabolites identification, proximate testing, and antioxidant analysis. The results showed a golden apple snails (Pomacea canaliculata L.) extract containing active compunds of alkaloids, flavonoids, tannins and polyphenols, steroids, and glycoside. Proximate analysis showed that golden apple snails extract had a high protein content of 40,83% compared to carbohydrates and fats. These findings suggested that golden apple snailsmeat extract has the potential to be further utilized as an alternative feed for Pangasius sp.Keywords: golden apple snails. Pangasius sp., proximate testing, secondary metabolites.
Offshoring de producción, innovación y capacidad de absorción
Authors: García Francisco , Avella Lucía , Valle Sandra
Published: July 2021

Entre otras ventajas, el offshoring puede facilitar la actividad innovadora, pues permite acceder a una amplia y variada gama de conocimiento. En esta investigación analizamos si algunas empresas están mejor preparadas que otras para beneficiarse de estas oportunidades de aprendizaje. En concreto, nos centramos en el papel que juega su capacidad para identificar, asimilar, integrar y aplicar conocimiento nuevo y externo. Nuestros resultados muestran que las empresas mejor dotadas de este tipo de capacidades mejoran en mayor medida sus resultados innovadores (medidos a través de sus solicitudes de patentes y modelos de utilidad) tras realizar offshoring de producción intermedia.
Productos sostenibles en mercados internacionales: el caso de Vesana
Authors: Gallucci-Suárez Claudia Milagros
Published: July 2021

El trabajo evidencia tendencias actuales en mercados internacionales con el propósito de diseñar el proceso de internacionalización de una empresa asturiana. En la actualidad, los consumidores demandan con mayor frecuencia productos ecológicos, del mismo modo que exigen buenas prácticas empresariales. Diversos estudios revelan que el auge de productos orgánicos se percibe con mayor claridad en las economías emergentes. Así pues, se elabora un Plan de Marketing Internacional para Vesana -una marca de cremas de verduras ecológicas con microalgas- con el fin de aprovechar un mercado potencial, en este caso México.
Pengaruh Efikasi Diri Dan Komunikasi Interpersonal Terhadap Kinerja Pprofesional Pustakawan
Authors: Zakaria Farid Andriansyah
Published: July 2021

Penelitian ini bertujuan untuk menganalisa pengaruh efikasi diridan komunikasi interpersonal terhadap kinerja pustakawan. Penelitian ini menggunakan pendekatan kuantitatif dan dilakukan pada 30 orang pustakawan perguruan tinggi negeri. Metode yang digunakan adalah metode survei dengan teknik analisis deskriptif dan verifikatif. Teknikpengumpulan data yaitu dengan kuesioner dengan menggunakan skala likert. Pengujian instrumen data dilakukan dengan uji validitas dan reliabilitas, sedangkan analisis data yang digunakan korelasi pearson product moment dan koefisien determinasi dan uji hipotesis dengan uji t.Berdasarkan hasil penelitian korelasi pearson product moment hubungan antara efikasi diri dengan kinerja profesional pustakawantermasuk kategori cukup signifikan dan bernilai positif. Berdasarkan uji t maka Ha diterima dan Ho ditolak, artinya ada pengaruh yang cukup signifikan antara efikasidiri terhadap kinerja pustakawan. Berdasarkan hasil korelasi pearson product moment hubungan antara komunikasi interpersonal dengan kinerja profesional pustakawan termasuk kategoricukup dan bernilai positif. Berdasarkan uji t maka Ha diterima dan Ho ditolak, artinya  adapengaruh yang cukup signifikan antara komunikasi interpersonal terhadap kinerja pustakawan. Berdasarkan Uji f didapatkan f hitung lebih besar dari pada F tabel, artinya efikasi diridan komunikasi interpersonal secara simultan memiliki pengaruh positif pada kinerja profesional pustakawan dan mampu memberikan pengaruh positif pada pelayanan secara profesional dapat memberikan layanan prima dan mendapatkan kepercayaan kepada pemustakanya.
Analisis Film Surga Yang Tak Dirindukan 2 Sebagai Self Help Biblioterapi
Authors: Salifa Maitsa Poetika , Agustina Susanti
Published: July 2021

Penelitian ini bertujuan untuk mendeskripsikan makna, pesan, dan insight yang terdapat pada film Surga Yang Tak Dirindukan 2 sebagai medium dalam pelaksanaan biblioterapi. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi literatur. Penelitian ini menunjukkan bahwa film Surga Yang Tak Dirindukan 2 dapat bermanfaat sebagai pemulihan jiwa bagi penontonnya. Partisipan dalam penelitian ini berjumlah 9 orang yang memiliki latar belakang kehidupan berbeda. Para penonton yang dapat menggunakan film ini sebagai medium biblioterapi adalah mereka yang mengalami masalah dalam keluarga, rumah tangga, dan pengidap kanker. Simpulan dari penelitian ini, pertama film ini bermakna bahwa kita bisa menjalankan semua permasalahan bila kita sabar, ikhlas, dan berserah diri kepada Tuhan Yang Maha Esa. Kedua, film ini mengandung pesan moral keihklasan dan kekuatan dari seorang perempuan. Ketiga, informan mendapat insight dari film ini, yaitu terdapat biblioterapi pada film Surga Yang Tak Dirindukan 2. Implikasi dari penelitian ini adalah biblioterapi dalam perkembangannya tidak terbatas pada buku, tetapi film juga dapat berguna sebagai medium terapi selama penyedia layanan biblioterapi mampu menganalisis dan mengeksplorasi teks pesan dalam film untuk direfleksikan penonton. Hal ini dapat dilakukan dengan atau tanpa bantuan biblioterapis atau pustakawan.
STRATEGI PENGELOLAAN DANA FILANTROPI DI MASA PANDEMI
Authors: Alawy Sholikudin , Zaki Irham
Published: July 2021

ABSTRAKIndonesia memiliki potensi dana filantropi yang sangat besar, antara lain zakat, infaq dan dana sosial keagamaan lainnya (DSKL). Di Indonesia, dana filantropi tersebut dikelola oleh Badan Amil Zakat (BAZ) dan Lembaga Amil Zakat (LAZ). Salah satu LAZ yang ada di Indonesia Lembaga Amil Zakat Infaq Shodaqoh Muhammadiyah (LAZISMU), dan memiliki salah satu LAZISMU Daerah yakni LAZISMU Bojonegoro. Namun pada tahun 2020, kegiatan LAZISMU Bojonegoro terganggu dengan merebaknya pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui bagaimana pengelolaan dana filantropi di lembaga tersebut pada tahun 2019 (sebelum pandemi) dan tahun 2020 (selama pandemi). Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif dengan strategi studi kasus eksploratori, dengan menggunakan data primer berupa wawancara dan data sekunder berupa dokumen. Hasil dari penelitian ini menunjukkan bahwa LAZISMU Bojonegoro berhasil beradaptasi pada kondisi pandemi, dibuktikan dengan meningkatnya penerimaan dana filantropi sebesar Rp. 720.736.219, atau sebesar 30,05% dari tahun sebelumnya, dan pendistribusian sebesar Rp. 567.913.837, atau 25,09% dari tahun sebelumnya, dan meningkatkan kualitas dan kuantitas penyaluran di bidang ekonomi.Kata kunci: Pengelolaan, Dana Filantropi, Pandemi COVID-19, LAZISMU Bojonegoro. ABSTRACTIndonesia has the potential for huge philanthropic funds, including zakat, infaq and other socio-religious funds (DSKL). In Indonesia, the philanthropic fund is managed by the Amil Zakat Agency (BAZ) and the Amil Zakat Institute (LAZ). One of the LAZ in Indonesia is the Amil Zakat Infaq Shodaqoh Muhammadiyah Institute (LAZISMU), and has one of the Regional LAZISMUs, namely LAZISMU Bojonegoro. However, in 2020, LAZISMU Bojonegoro's activities will be disrupted by the outbreak of the COVID-19 pandemic. This study aims to determine how philanthropic funds are managed at the institution in 2019 (before the pandemic) and in 2020 (during the pandemic). The research method used in this research is a qualitative method with an exploratory case study strategy, using primary data in the form of interviews and secondary data in the form of documents. The results of this study indicate that LAZISMU Bojonegoro has successfully adapted to pandemic conditions, as evidenced by the increase in the receipt of philanthropic funds amounting to Rp. 720,736,219, or 30.05% from the previous year, and the distribution was Rp. 567,913,837, or 25.09% from the previous year, and increasing the quality and quantity of distribution in the economic sector.Keywords: Management, Philanthropy Fund, COVID-19 Pandemic, LAZISMU Bojonegoro.
Barriers to Access of Healthcare Services for Rural Women – Applying Gender Lens on TB in a Rural District of Sindh, Pakistan
Authors: Habib Shifa Salman , Jamal Wafa Zehra , Zaidi Syed Muhammad Asad , Siddiqui Junaid ur-Rehman , Khan Hira Mustafa , Creswell Jacob , Batra Srichand , Versfeld Anna
Published: July 2021

Background: Women in rural districts of Pakistan face numerous barriers to healthcare, rendering gender-responsive health programming important, including for Tuberculosis (TB). This study was conducted to assess the general understanding of TB and of access to healthcare for women, as a first step towards implementation of a gender responsive TB programme in TandoAllayar, a rural district of Pakistan. Methods: A total of 36 participants were interviewed. The focus group discussion guide comprised of questions on: (1) family/household dynamics (2) community norms (3) healthcare system (4) women’s access to healthcare (5) TB Awareness;, and (6) women’s access to TB Care. Results: Limited autonomy in household financial decision-making, disapproval of unassisted travel, long travel time, lack of prioritization of spending on women’s health and inadequate presence of female health providers, were identified as barriers to access of healthcare for women, higher in younger women. Facilitators to access of TB care included a reported lack of TB-related stigma, moderate knowledge about TB disease, and broad understanding of tuberculosis as a curable disease. Other suggested facilitators include health facilities closer to the villages and the availability of higher quality services. Conclusion: Significant barriers are faced by women in access to TB care in rural districts of Pakistan. Programme implementers in high burden countries, should shift towards improved gender-responsive TB programming.
Fungal Biovalorization of a Brewing Industry Byproduct, Brewer’s Spent Grains: A Review
Authors: Marcus Andrew , Fox Glen
Published: July 2021

The beer industry is a major producer of solid waste globally, primarily in the form of brewer’s spent grains (BSG), which due to its low value has historically been diverted to livestock as feed or to landfills as waste. Its high moisture content and chemical composition positions BSG as an ideal candidate for further processing with microbial fermentation, and recent research has focused on filamentous fungi and the ability of some species therein to degrade the predominant recalcitrant cellulolignin components of BSG to produce valuable compounds. Many species have been investigated to biovalorize this waste stream, including those in the genuses Aspergillus, Pennicillium, Rhyzopus, and Trichoderma, which have been used to produce a wide array of highly valuable enzymes and other functional compounds, and to increase the nutritional value of BSG as an animal feed. This review of recent developments in the application of filamentous fungi for the valorization of BSG will discuss the biochemical makeup of BSG, the biological mechanisms underlying fungi’s primacy to this application, and the current applications of fungi in this realm. As the majority of these studies are at lab-scale, the challenges to scale-up and more widespread application and will be discussed as well.
MAKING A LIVING ON CORAL ATOLL: CHANGING STRATEGIES AMONG MILLENNIALS ON BALOBALOANG ISLAND, SOUTH SULAWESI, INDONESIA
Authors: Ammarell Gene , Muslimin Muslimin , Oda Sukur , Faisal R Ahmad
Published: July 2021

Beginning around 2014, some significant changes in the livelihoods among many younger men from the Island of Balobaloang, South Sulawesi, Indonesia, emerged.  This study describes and explains how it is that approximately 50 working-age adult men (out of a total population of about 900) have turned away from interisland shipping and trade and artisanal fishing and toward wage employment aboard tourist ships, working out of distant ports in Indonesia.  This case study uses a qualitative approach to explore and describe the socio-economic life of community members on the island village of Greater Balobaloang as they continue to be affected by economic and environmental changes.  Field data collection was carried out through observation, government documents, and in-depth interviews with respondents.  In particular, this study focuses on the adaptive strategies of younger men as opportunities for making a living have shifted in recent years away from artisanal fishing and interisland shipping and trade to adventure travel aboard modified traditional sailing ships.  It contributes to discussions of internal skilled migration, social mobility and adaptation to the domestic and international tourist industry.
SAVING PATTERN OF SMALL-SCALE WOMEN RICE FARMERS IN SAN JOSE, OCCIDENTAL MINDORO
Authors: Ruedas Mary Yole Apple Declaro , Guico Mary Joy
Published: July 2021

The study aims to assess the saving and investment pattern of women rice farmers in San Jose, Occidental Mindoro. The study was conducted in the rice-producing barangays of San Jose, Occidental Mindoro, namely: Mabini, Mapaya, and Mangarin from February to July 2017. The study population included all women farmers who were involved in different rice farming activities from production to marketing. The 48 respondents were randomly selected. Informed consent was sought before the conduct of the study. Descriptive statistics like mean, percentages, and frequency distribution were used to assess the women farmers' profile. While Pearson Moment Correlation was used to test the relationship between the variables. The result shows that the small-scale women farmers have a small household size and small farm sizes with an income above the poverty threshold. They "sometimes" save through cash and "frequently" save through non-cash. They "frequently" encountered problems in saving capacity. Further, farm size is significantly related to the savings pattern of women rice farmers. Socio-economic characteristics have no relationship with constraints to saving capacity. The study suggests using other variables to further determine the saving pattern and saving capacity of the women rice farmers.
LAND GRABBING OR RICE SECTOR DEVELOPMENT OPPORTUNITY? THE CASE OF WANBAO PROJECT IN GAZA, MOZAMBIQUE
Authors: Ponguane Sérgio Jordão Augusto , Mussumbuluco Bento , Mucavele Nézia
Published: July 2021

Demand for agricultural land by foreign investors has been increasing in Mozambique over the last years and the Wanbao project is an example. The implementation of this project in Gaza has divided opinions between the government, civil society and academia. This study aims to contribute to the debate on whether Wanbao project can be considered as land grabbing and the extent to which the project contributes to the development of small-scale agriculture in Gaza Province. Data were collected through a semi-structured questionnaire in December 2019 and January 2020, covering a total of 66 household affected by the Wanbao project. The data were analyzed by a descriptive statistic and a cross-check of the Mozambican land law, the available literature on land grabbing and the information collected on the ground from the farmers affected by the project. The results show that the land concession to Wanbao was made without any consideration of customary rights, however, it was found that the contract farming program can increase rice productivity in the short term, but its sustainability remains questionable. Thus, if the Mozambican government intends to transform agriculture through large investments, it must ensure that the concession of land respects customary rights and the companies involved ensure the transfer of technologies in an effective and sustainable manner.
MAKING TECHNOLOGIES WORK IN RURAL COMMUNITIES: THE CASE OF FLATBED DRYER APPROPRIATION IN STO. DOMINGO, NUEVA ECIJA, PHILIPPINES
Authors: Vallejo Chrysl Avegeil , Torres Cleofe , Torres Cleofe , Velasco Ma. Theresa , Velasco Ma. Theresa , Flor Benjamina Paula , Flor Benjamina Paula , Dizon Josefina , Dizon Josefina
Published: July 2021

This paper aimed to explain how rice farmers in Sto. Domingo, Nueva Ecija, Philippines managed to properly appropriate flatbed dryers. It also sought to describe the modes of appropriation offlatbed dryers: adoption, adaptation, and peer/group learning.  Data were gathered through a survey among 131 rice farmers and key informant interviews. Findings revealed that the rice farmers experimented and modified the features of flatbed dryers to better adapt the technology to their needs. The rice farmers have encountered problems in using the technology but have managed to employ adaptation strategies to address these problems which resulted to peer/group learning among them.
Pengaruh Strategi Kewirausahaan dan Modal Sosial Terhadap Kinerja Keuangan serta Non-Keuangan Melalui Manajemen Rantai Pasokan Berkelanjutan
Authors: Kingkin Nurani Yekty  , Grace Tianna Solovida
Published: July 2021

Penelitian ini bertujuan untuk menguji pengaruh strategi kewirausahaan dan modal sosial terhadap kinerja organisasi dengan manajeman rantai pasokan berkelanjutan (MRPB) sebagai variabel mediasi. Manajeman rantai pasokan berkelanjutan memiliki pengaruh penting dalam pengukuran organisasi diberbagai industri. Hal tersebut digunakan dalam mempertimbangkan dampak lingkungan dan tanggungjawab pemasok. Penelitian ini memperoleh populasi sebanyak 31 perusahaan manufaktur di Jawa Tengah dengan manajer logistik sebagai kunci utama dan menerapkan manajeman rantai pasokan berkelanjutan. Metode analisis data menggunakan partial least square (PLS). Hasil penelitian menunjukkan bahwa strategi kewirausahaan dan modal sosial memiliki pengaruh terhadap kinerja organisasi dan manajeman rantai pasokan berkelanjutan. Serta manajeman rantai pasokan berkelanjutan memediasi antara kinerja organisasi dan strategi kewirausahaan, sementara pada modal sosial manajeman rantai pasokan berkelanjutan tidak memediasi terhadap variabel kinerja organisasi.
Analisis Determinan Transfer Pricing pada Perusahaan Multinasional yang Terdaftar di Bursa Efek Indonesia
Authors: Agata Gracia , Putu Indrajaya Lembut  , Fitri Oktariani
Published: July 2021

Penelitian ini bertujuan untuk menganalisis pengaruh Multinasionalitas, Tax Haven dan Thin Capitalization terhadap Transfer Pricing. Sampel dalam penelitian ini adalah seluruh perusahaan multinasional yang terdaftar di Bursa Efek Indonesia dari tahun 2016 hingga 2019 selain sektor keuangan, asuransi, pertambangan dan properti. Jumlah data yang sesuai dengan kriteria sampel adalah 260 data yang terdiri dari 65 perusahaan untuk tiap tahunnya. Metode analisis yang digunakan dalam mengolah data menggunakan analisis linier berganda. Penelitian ini menggunakan program Statistical Package for Social Sciences (SPSS). Hasil penelitian menunjukkan bahwa multinasionalitas dan tax haven tidak berpengaruh terhadap transfer pricing, dan thin capitalization berpengaruh positif terhadap transfer pricing.
A Trial of Intra-Pleural BacteriaL ImmunoTherapy In Malignant Pleural Mesothelioma (TILT) – A Randomised Feasibility Study Using The Trial Within A Cohort (TwiC) Methodology
Authors: Bibby Anna C , Zahan-Evans Natalie , Keenan Emma , Comins Charles , Harvey John E , Day Helen , Rahman Najib M , Fallon Janet E , Gooberman-Hill Rachael , Maskell Nick A
Published: July 2021

BackgroundMalignant pleural mesothelioma (MPM) is an aggressive thoracic malignancy with a poor prognosis. Systemic immunotherapy is an effective front-line treatment for MPM, and there is a scientific rationale supporting the possible efficacy of local i.e. intra-pleural immune modulators. TILT investigated the feasibility of performing a randomised trial of intra-pleural bacterial immunotherapy in people with MPM, using the trials within cohorts (TwiC) methodology. MethodsTILT was a multi-centre, three-armed, randomised, feasibility TwiC of intra-pleural OK432, BCG or usual care in people with MPM. Eligible participants were identified from within the ASSESS-meso study; a prospective, longitudinal, observational cohort study, and were randomly selected to be offered a single dose of OK432 or BCG, via an indwelling pleural catheter. The primary outcome was feasibility, evaluated against pre-specified recruitment, attrition and data completeness targets. The acceptability of trial processes and interventions were assessed during qualitative interviews with participants and family members at the end of the trial. TILT was registered prospectively on the European Clinical Trials Registry (EudraCT number 2016-004727-23) and the ISRCTN Register on 04/12/2017. ResultsSeven participants were randomised from a planned sample size of 12, thus the 66% recruitment rate target was not met. Two participants withdrew after randomisation, breaching the pre-stated attrition threshold of 10%. It was not possible to maintain blinding of control participants, which negated a fundamental tenet of the TwiC design. The trial processes and methodology were generally acceptable to participants and relatives, despite several recipients of intra-pleural bacterial agents experiencing significant local and systemic inflammatory responses. ConclusionDesign of a clinical trial of an investigational medicinal product based on the TwiC design and obtaining the necessary regulatory approvals was possible. However, whilst acceptable to participants and relatives, the TwiC design was not a feasible method of investigating intra-pleural bacterial immunotherapy in people with MPM. Future trials investigating this topic should consider the eligibility constraints and recruitment difficulties encountered.
Correlation between different anticoagulation schemes of pregnant women with mechanical prosthetic heart valves and adverse fetal/neonatal outcomes
Authors: Zhao Ziwen , Yang Xi , Su Ying , Zhang Jun , Li Yanna , Liu Guiying
Published: July 2021

Pregnant women with mechanical prosthetic heart valves (MPHV) have adverse effects on the growth and development of the fetus. Data on MPHV pregnant women and their offspring from our hospital from 2014 to 2020 were retrospectively collected. There were 137 pregnancies, 96 in the warfarin group, 28 in the low-molecular-weight heparin (LMWH) group, 13 in the sequential treatment group. There are 27 cases of spontaneous abortion, 3 cases of stillbirth, 56 live births and 51 artificial abortion. The international normalized ratio (INR, P < 0.001), prothrombin time (PT, P = 0.014), activated partial thromboplastin time (APTT, P = 0.035) of the neonates in the warfarin group were increased compared with the other two groups. Multivariate Tobit regression analysis showed that the probability of spontaneous abortion/stillbirth was positively correlated with INR before delivery (OR 1.13, P = 0.009) and valve usage time (OR 1.13, P = 0.009). The probability of malformation was positively correlated with worse heart function level (OR 1.20, P = 0.025) and INR (OR 1.18, P = 0.011) before delivery. The offspring of MPHV pregnant women who continuously take warfarin have poor outcomes and a significantly higher risk of early bleeding. Prenatal consultations for MPHV women should be strengthened to avoid unplanned pregnancy.
Risk Factors Influencing Cerebral Venous Infarction After Meningioma Resection
Authors: cai qing , Wang Shoujie , Zheng Min , Wang Xuejiao , Liu Rong , Liu Liqin , Qin Huaizhou , Feng Dayun
Published: July 2021

Introduction Cerebral venous infarction is a serious complication after meningioma resection. To reduce the incidence of venous infarction, we identified risk factors for postoperative cerebral venous infarction after surgical resection of meningioma in patients with clinical symptoms.Methods The clinical and imaging data of 1127 patients with intracranial meningiomas who underwent resection in our hospital were retrospectively collected and analyzed. Cerebral venous infarction was evaluated by postoperative imaging and clinical manifestations. Univariate and multivariate analyses were performed to identify risk factors associated with cerebral venous infarction.Results Overall, 3.3% (37/1127) of patients experienced symptomatic cerebral venous infarction after meningioma resection. Multivariate analysis revealed superficial meningioma, moderate to severe peritumoral edema, peritumoral critical vein and WHO grade II-III as independent predictors of a postoperative cerebral venous infarction. After timely intervention, the symptoms were clearly alleviated in one month, and the prognosis was good, but injury to key veins could cause irreversible neurological disorders.Conclusions Intraoperative protection of veins is the primary way to prevent cerebral venous infarction. The present study identified several significant and independent risk factors for postoperative venous infarction, thereby enabling the identification of high-risk patients who require special attention during clinical and surgical management.
Incidence and Potential Risk Factors of Catheter Associated Thrombosis in Solid Tumors
Authors: Mateo Francisco José Pelegrín , Arias Asia Ferrández , González Lucía Gómez , Verdúguez Teresa Quintanar , Heredia Irene Belmonte , Justamante Jaime Belmonte , Gómez Pilar Calderón , García María Carmen García , Manzanera Matilde Miguel , Lescure Álvaro Rodríguez
Published: July 2021

PurposeCentral venous catheters (CVCs) have become common practice in oncology. Besides their benefits, as an invasive procedure, several complications are associated with them. Catheter associated thrombosis (CAT) is one of the most relevant due to their impact in quality of life and mortality, but the prothrombotic risk factors implied have been poorly assessed. The aim of the study is to evaluate the incidence of upper extremity deep vein thrombosis (UEDVT) associated to catheter use in patients with solid tumors. Secondary endpoints are to describe the population using CVCs and to evaluate potential risk factors of CAT. MethodsPatients diagnosed of solid tumors assisted at a tertiary level hospital between 2016 and 2019, and using CVCs were included.Results455 patients were enrolled. The incidence of CAT was 5.49% (25) in the whole population. 5.05% (23) was associated with PICC while 0.44% (2) was due to PORT use. Among the factors included in the univariate and multivariate regression models, age ≥50 years and PORT use were identified as protective factors related to the development of CAT.ConclusionCVCs remains a safe approach for the delivering of treatments in patients with solid tumors. Age ≤50 and use of PICC are risk factors for developing CAT. Larger prospective studies are needed to identify additional risk factors of CAT.
Expression of Cell Proliferation Regulatory Factors Bricd5, Tnfrsf21, Cdk1 Correlates With Expression of Clock Gene Cry1 in Testis of Hu Rams During Puberty
Authors: Huang Yongjie , Jiang Xun Ping , Liu Guiqiong , Liu Chen Hui
Published: July 2021

The cry1 gene plays an important role in mammalian ontogeny and widely exists in various tissues. Studies showed that cry1 gene was expressed in testis and participated in the regulation of mammalian reproductive activities. To identify the genes that are positively correlated with cry1 gene expression in the testis of rams during the first estrus, and to explore the relationship between cry1 gene and the number of spermatogenic cells. qRT-PCR was used to detect the mRNA transcription levels of cry1, bricd5, tnfrsf21, cdk1 and tcfl5 in testicular tissues of Hu sheep at 0, 30, 60, 90, 120, 150 and 180 days postpartum (dpp) . In testicular tissue, the expression of cry1 mRNA increased with age in testis showed an upward trend, and increased significantly in the estrous phase. The cry1 mRNA at 180dpp was significantly higher than that of 90-day-old testis (p < 0.05). The expression of cell proliferation related genes bricd5, tnfrsf21, cdk1, cry1 upstream specific transcription factor tcfl5 was identified, and the mRNA expression at 180 dpp was significantly higher than that of 3-month-old testis (p < 0.05) The expression level of cry1 mRNA was similar to that of cry1. cry1 gene is highly expressed in the testis of sheep during puberty, and has a significant correlation with the proliferation of spermatogenic cells.
The effect of early enteral nutrition on intestinal mucosal barrier and remote organs in rats with severe acute pancreatitis
Authors: Song Jianbo , Lu xiaoguang , Zhan Libin , Kang Xin , Zhong Yilong , Yang Yilun , Wang Yi , Guo Wenxiu , Song Yi
Published: July 2021

Background

The mechanism of early enteral nutrition on intestinal mucosal barrier is still not fully understood and the direct evidence to demonstrate the protective effects of early enteral nutrition against remote organs injury induced by severe acute pancreatitis is lacking.
Methods

Rats were randomly divided into three groups: 1) only flip pancreas and free diet (n = 8); 2) severe acute pancreatitis and total parenteral nutrition (n = 15); 3) severe acute pancreatitis and early enteral nutrition (n = 15). Severe acute pancreatitis was induced by the retrograde injection of pancreaticobiliary duct with sodium taurocholate. Nutritional supplementation was administered starting 12 hours after induction of pancreatitis. The samples were obtained after the treatment of nutrition 72 hours.
Results

The mortality was not significant difference between the experimental groups. The pathology of ileum and the content of serum diamine oxidase were significantly lower in early enteral nutrition group than total parenteral nutrition group. The expression of tight junction ZO-1, Occludin and Claudin-1 proteins and the intraepithelial CD8+ and TCRγδ+ lymphocytes were significantly higher in early enteral nutrition group than total parenteral nutrition group. The content of the serum amylase and endotoxin were significantly lower in early enteral nutrition group than total parenteral nutrition group. There was a tendency of decreased pancreas and lung pathology scores in early enteral nutrition group, but the difference between total parenteral nutrition and early enteral nutrition groups was not significant.
Conclusion

The early enteral nutrition could significantly improve the expression of the tight junctions and intraepithelial lymphocytes, accompanied by improved intestinal mucosal barrier and endotoxin, but failed to the pancreas and lung injury compared to total parenteral nutrition in the rat model of severe acute pancreatitis.
Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine
Authors: Secondo Agnese , Petrozziello Tiziana , Boscia Francesca , Tedeschi Valentina , Pannaccione Anna , de Rosa Valeria , Corvino Angela , Severino Beatrice , Annunziato Lucio
Published: July 2021

Background: The cycad neurotoxin beta-methylamino-L-alanine (L-BMAA), causing the amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC), may cause neurodegeneration by disrupting organellar Ca2+ homeostasis. By activating Akt/ERK1/2 pathway, the Cu,Zn-superoxide dismutase (SOD1) and its non-metallated form, ApoSOD1, prevent endoplasmic reticulum (ER) stress-induced cell death in motor neurons exposed to LBMAA. This occurs through the rapid increase of intracellular Ca2+ concentration ([Ca2+]i) in part flowing from the extracellular compartment and in part released from ER. However, the molecular components of this mechanism remain uncharacterized.Methods: By an integrated approach consisting on the use of siRNA strategy, Western blotting, confocal double labeling immunofluorescence, patch-clamp electrophysiology, and Fura 2- /SBFI-single-cell imaging, we explored in rat motor neuron-enriched cultures the involvement of plasma membrane Na+/Ca2+ exchanger (NCX) and the purinergic P2X7 receptor as well as of the intracellular cADP-ribose (cADPR) pathway in the rapid and neuroprotective mechanism of SOD1.Results: we showed that SOD1-induced [Ca2+]i rise was prevented by the pan inhibitor of NCX CB-DMB but not by A430879, a P2X7 receptor specific antagonist, or by 8-bromo-cADPR, a cell permeant antagonist of cADP-ribose. The same occurred for the ApoSOD1. Confocal double labeling immunofluorescence showed a huge expression of plasmalemmal NCX1 and intracellular NCX3 isoforms. Furthermore, we identified NCX1 reverse mode as the main mechanism responsible for the neuroprotective ER Ca2+ refilling elicited by SOD1 and ApoSOD1. Furthermore, SOD1 and ApoSOD1 promoted translocation of active Akt in some nuclei of primary motor neurons. Finally, the activation of NCX1 by the specific agonist CNPYB2 protected motor neurons from L-BMAA-induced cell death.Conclusion: collectively, our data indicate that SOD1 and ApoSOD1 exert their neuroprotective effect by modulating ER Ca2+ content through the activation of NCX1 reverse mode and Akt nuclear translocation in a subset of primary motor neurons.
Population-based Study of Cutaneous Malignant Melanoma in the South Region of Portugal: Epidemiological and Clinical Characterization (2016-2017)
Authors: Costa Filipa Alves da , Bernardo Catarina , Borges Fábio Cardoso , Ramos Adriana , Miranda Ana Costa
Published: July 2021

An historical population-based cohort study was conducted aiming to estimate the incidence of cutaneous malignant melanoma in the South Region of Portugal between Jan 2016 and June 2017; to clinically characterize the diagnosed individuals; to describe instituted treatment; and to estimate survival outcomes. Data were extracted from a cancer registry (ROR-Sul) covering 4 800 000 inhabitants (46% of the Portuguese population) and included a total of 789 individuals meeting eligibility criteria. The cumulative incidence rate (18 months) of melanoma was 13.36/100,000 inhabitants and the Age-Standardized Incidence Rate per 100,000 World population was 8.43/100,000 inhabitants. The most common histological subtypes identified were superficial extension, followed by malignant melanoma and nodular melanoma. Most cases were diagnosed in stage I (50.39%), equally distributed by sex and with a median age of 65 years. During the study period, 174 recurrence events were recorded (23.45%) and recurrence-free survival rate was significantly lower in more advanced stages. Patients had a two-fold risk of recurrence/death when in presence of ulcerated tumors [adjusted hazard ratio (adj HR) = 2.28; 95% confidence interval (CI): 1.40–3.70]. Overall survival rate at 3-years was 80.54% (77.58–83.15) and survival was considerably higher for individuals diagnosed at earlier stages. The epidemiologic and clinical characteristics of malignant melanoma patients studied are consistent with international literature. Treatment instituted by Portuguese clinicians is aligned with evidence-based guidelines published. The increase in the incidence rate observed suggests additional public health campaigns are needed to modify behaviours of the Portuguese population and thus reduce their risk.
Diagnosis of De Novo Mosaic Balanced Translocation t(1;3)(q42;q25) in a Fetus Conceived Using Pre-implantation Diagnosis Due to Presence in the Father of a Different Balanced Translocation
Authors: Zhang Shaoqin , zhu jianjiang , Qi Hong , Xu Limei , Cai Lirong , Meng Ran
Published: July 2021

IntroductionPreimplantation genetic testing (PGT) had widely been applied in reciprocal translocation carriers to improve the clinical outcome of assisted reproduction. De novo mosaicism balanced reciprocal translocations in fetus conceived using PGT from a balanced translocation carrier parent has been rarely reported, and the driving mechanism is not clearly. MethodsChromosomal microarray analysis (CMA) , karyotype analysis and fluorescent in situ hybridization (FISH) were performed to verify the type and heredity of the rearrangement. STR analysis was used to identify potential contamination as well as kinship verification and identification. ResultsA rare de novo mosaicism balanced reciprocal translocation t(1,3)(q42;q25) in fetus conceived using PGT-SR from a t(12;14)(q22;q13) balanced translocation carrier father was been diagnosed by multiplatform genetic techniques. At 31 weeks and 2 days of gestation, premature delivery was caused by uncontrollable uterine contractions. At the 21-months follow up, infant has achieved all psychomotor development milestones as well as growth within the normal reference range. Conclusion﻿PGT cases still need close observation in prenatal diagnosis and long-term follow-up.
The Study of Ocular Parameters in Low to Moderate Myopic Chinese Children Age Between Eight to Eighteen-Year-Old
Authors: Li Zhengxuan , Sun Lu , Song Hongxin
Published: July 2021

Purpose: The primary aim of this study was to analyze the distribution of ocular parameters of children aged from eight to eighteen-year-old with low to moderate myopia as well as offer useful information for the design and clinical fitting of ortho-k lens in China.Methods: In this retrospective study, we collected data of 300 subjects (600 eyes) age between eight to eighteen-year-old from the myopic control outpatient clinic at Beijing Tongren Hospital, Beijing, China. The spherical equivalent (SE), axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), corneal endothelial cell density (CECD)，corneal diameter (CD), simulated K (Sim K) were collected from all the subjects and analyzed. Results: The mean of SE for all subjects was -3.12 ± 1.21D, the median was -3.16D. The mean of AL for all subjects was 24.72 ± 0.83 mm, the median was 24.72 mm. The mean of CCT for all subjects was 537.8 ± 29.82 μm, the median was 538.17 μm. The mean of CECD for all subjects was 3340.3 ± 352.6 cells/mm2, the median was 3357.77 cells/mm2. The mean of ACD for all subjects was 3.71 ± 0.21 mm, the median was 3.69 mm. The mean of CD for all subjects was 12.15 ± 1.67 mm, the median was 12.05 mm. The mean of flat K was 42.80 ± 1.29, the median was 42.81. The mean of steep K was 43.76 ± 1.37, the median was 43.76.Conclusions: This study provided the distribution of ocular parameters to offer useful information for diagnosis of many eye conditions. Meanwhile, the distribution of ocular parameters of children aged from eight to eighteen-year-old with low to moderate myopia is beneficial to make the application of overnight orthokeratology lens more appropriate and effective.
Factors Affecting Retention in the Philippine National Rural Physician Deployment Program From 2012 to 2019: A Mixed Methods Study
Authors: Flores Erika Louise L. , Manahan Edric Matthew R. , Lacanilao Miguel Paolo B. , Ladaw Isabella Ma. Beatriz T. , Mallillin Mico Martin B. , Mappatao Nikolai Thadeus Q. , Leonardia Juan Alfonso , Pepito Veincent Christian F.
Published: July 2021

BACKGROUND: To address the maldistribution of healthcare providers and the shortage of physicians in geographically isolated and disadvantaged areas of the Philippines, the Philippine National Rural Physician Deployment Program, or more commonly known as the Doctors to the Barrios (DTTB) program was established in 1993. However, as of 2011, only 18% of the DTTBs chose to stay in their assigned municipalities after their two-year deployment, termed retention. This study aims to identify the individual, local, work, national, and international factors affecting the retention of DTTBs in their assigned communities after their two-year deployment. METHODS: A descriptive, mixed-methods design was used. For the quantitative part, the modified and updated Stayers Questionnaire was given to all current DTTBs present in a Continuing Medical Education session in the Development Academy of the Philippines. Descriptive statistics were then presented. For the qualitative part, individual, semi-structured key informant interviews were conducted in-person or via phone with current and alumni DTTBs from 2012 to 2019. Proceedings of the interviews were transcribed, translated, and analyzed thematically. RESULTS: 102 current DTTBs participated in the quantitative part of our study, while 10 current and former DTTBs participated in the interviews. Demographic factors and location, personal beliefs, well-being, friends and family dynamics, and perceptions about work were the individual factors identified to affect retention. Social working conditions, career development, and infrastructure, medical equipment, and supplies were among the work factors identified to affect retention. Geography, living conditions, local social needs, and technology were among the local factors identified to affect retention. Compensation, the recently signed Universal Healthcare Law, and Safety and Security were identified as national factors that could affect retention. International factors did not seem to discourage DTTBs from staying in their communities. CONCLUSIONS: A host of individual, work-related, local, national, and international factors influence the DTTB’s decision to be retained in different, complex, interconnected, and dynamic ways. We also identified implementation issues in the DTTB program and suggested interventions to encourage retention.
The Brain’s Structural Differences in Peripheral Neuropathic Pain: A Comparison Study Between Postherpetic Neuralgia and Lower Back Pain
Authors: Qiu Jianxing , Du Mengjiao , Yang Junzhe , Lin Zengmao , Qin Naishan , Sun Xiaowei , Li Linling , Zou Rushi , Wei Juan , Wu Bing , Liu Jing , Zhang Zhiguo
Published: July 2021

The purpose is to explore the brain’s structural difference in local morphology and between-region networks between two types of peripheral neuropathic pain (PNP): postherpetic neuralgia (PHN) and lower back pain (LBP). A total of 54 participants including 38 LBP and 16 PHN patients were enrolled. The average pain scores were 7.6 and 7.5 for LBP and PHN. High-resolution structural T1 weighted images were obtained. Both grey matter volume (GMV) and morphological connectivity (MC) were extracted. An independent two-sample t-test with false discovery rate (FDR) correction was used to identify the brain regions where LBP and PHN patients showed significant GMV difference. Next, we explored the differences of MC network between LBP and PHN patients and detected the group differences in network properties by using the two-sample t-test and FDR correction. Compared with PHN, LBP patients had significantly larger GMV in temporal gyrus, insula and fusiform gyrus (p < 0.05). The LBP cohort had significantly stronger MC in the connection between right precuneus and left opercular part of inferior frontal gyrus (p < 0.05). LBP patients had significantly stronger degree in left anterior cingulate gyrus and left rectus gyrus (p < 0.05) while had significantly weaker degree than PHN patients in left orbital part of middle frontal gyrus, left supplementary motor area and left superior parietal lobule (p < 0.05). LBP and PHN patients had significant differences in the brain’s GMV, MC, and network properties, which implies that different PNPs have different neural mechanisms concerning pain modulation.