bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastro-oesophageal reflux: An overview of the cost-effectiveness of pharmacotherapeutic treatment options
Authors: Schellack Gustav , Meyer J. C. , Schellack Natalie
Published: November 2022

Gastro-oesophageal reflux disease (GORD) produces symptoms that cause great irritation to the patient. Pharmacotherapeutic management is directed at minimising these symptoms and reducing the causative factors, e.g. acid production, thereby providing relieve. Currently available agents include simple antacids and acid suppression therapy, including histamine 2-receptor antagonists, proton pump inhibitors, mucosal or cytoprotective agents, pro-motility agents. Deciding on appropriate therapy will be dependent on the diagnosis, side-effects and cost-effectiveness of the treatment.
The dissonance between teaching and practice
Authors: Ellis Chris
Published: November 2022

No abstract available.
Insomnia disorder: when sleep plays coy, aloof and disdainful
Authors: Outhoff K.
Published: November 2022

Intermittent or acute insomnia is common and may sometimes require short term treatment with approved hypnotic agents. A diagnosis of insomnia disorder, however, indicates that poor night-time sleep is chronic and is accompanied by significant impairment of daytime functioning. Although insomnia disorder often co-exists with psychiatric and medical conditions, it is viewed as an independent entity with potentially serious sequelae, requiring its own treatment, usually in the form of cognitive behavioural therapy (CBT), with or without pharmacotherapy.
Paediatric pain management
Authors: Schellack Natalie , Matimela Molebogeng
Published: November 2022

Pain is defined by the International Association for the Study of Pain (IASP) as an “unpleasant sensory and emotional experience, associated with actual or potential tissue damage or described in terms of such damage”. It can be steady, throbbing, stabbing, aching, pinching or described in many other ways as being either acute or chronic pain. This pain definition can be applied to any patient, regardless of his/her age; however, paediatric pain expression is dependent on the child’s level of cognitive development and sociocultural background. Children older than four years of age can usually talk about their pain; at the age of six to eight years they can use the visual analogue pain (VAP) scale in the same manner as adults. Nevertheless, their capacity to describe pain increases with age and changes throughout their developmental stages. This article provides an overview of paediatric pain management.
Stress-related IBS
Authors: Outhoff K.
Published: November 2022

The gastrointestinal tract is exquisitely sensitive to different physical and psychological stressors. Irritable bowel syndrome (IBS) may be viewed as a disorder caused by stress-induced dysregulation of the complex interactions along the brain-gut-microbiota axis, which involves the bidirectional, self-perpetuating communication between the central and enteric nervous systems, utilising autonomic, psychoneuroendocrine, pain modulatory and immune signalling pathways. An overzealous stress response may significantly alter not only the sensitivity of the central and enteric nervous systems, but also other potentially important factors such as gut motility, intestinal mucosal permeability and barrier functioning, visceral sensitivity, mucosal blood flow, immune cell reactivity and enteric microbiota composition. Symptoms of these (mal)adaptive changes may include constipation, diarrhoea, bloating and abdominal pain, manifesting clinically as IBS. This article briefly reviews the current postulated stress-models of IBS.
Non-fatal injuries of interpersonal violence at the Leratong Provincial Hospital, South Africa
Authors: Amashnee Saimen , Guinevere Gordon , Indiran Govender
Published: November 2022

Background: Interpersonal violence is a global health issue. More than 1.6 million people die annually as a result of violence. Injured survivors suffer from a range of physical, sexual, reproductive and mental health problems. The aim of this study is to describe the trends and profile of violence-related injuries from hospital records of an urban emergency department and crisis centre in South Africa.Methods: A descriptive study was conducted by reviewing patient files at Leratong Hospital. Relevant clinical information such as victim’s age and gender; time, day of hospital attendance; nature of injury; presence/absence of alcohol; and nature of weapon was extracted.Results: Leratong Hospital manages many patients with injuries due to interpersonal violence throughout the year, with an increase in May, November and December. Higher numbers of patients present in the last week of the month, and on Saturdays and Sundays. Victims were predominantly male (64%), except for sexual assault where the victims were females. Females also suffered more blunt injuries than penetrating injuries. Blunt injuries were the most frequent type of injury although over the weekend males sustained more penetrating injuries than blunt injuries. Young males were the main victims of interpersonal violence.Conclusion: This study highlights a trend where young adults, especially males, are noted to be significantly affected by interpersonal violence.
Pragmatism in the lenses of African Christianity: An emic approach to lived religions
Authors: Mokhoathi Joel
Published: November 2022

African Christianity, as the synthesis of Christianity and African Traditional Religion, is often perceived as an ideal form of belief and practice that informs religious worship and ethics for nominal Christians. However, this form of expression is mostly dismissed by conservative Christians and African rigorist religionists as being syncretistic, and thereby seeing it as the ‘pollution’ of both religions, Christianity and African Traditional Religion. Even more criticism is given to those who regard themselves as Christians and African religionists – as they are assumed to have dual identities. In this paper, I explore the validity of African Christianity, as practiced by nominal Christians, through the lenses of pragmatism. This is imperative because pragmatism, as a theory of truth, rejects the separation of rational cognition and purpose. Thus, it posits that one cannot separate the people’s systems of belief and forms of knowing from their social context, which they must inherently live by and inform their actions. The aim of this paper, therefore, is to locate and unfold the emic experiences of the experiencers of African Christianity, and to interrogate their lived experiences as guided by pragmatism as the theoretical premise.
Design and Implementation of an Intelligent IoT System based on Fuzzy Logic for Carbon Monoxide Detection
Authors: Bekkouche Amina , Hadjila Mourad , Merzoug Mohammed , Hadjila Fethallah
Published: November 2022

Carbon monoxide (CO) as been frequently identified as the origin of deadly domestic accidents. The heavy toll it makes every winter is often caused by using gas heaters. CO is difficult to detect without a detector because it has not particular odor or color. In this paper, we create and implement a prototype based on the Internet of Things (IoT) to combat this dangerous gas and save human lives. This prototype first allows the detection of carbon monoxide leaks and then the execution of the necessary reactions based on fuzzy logic. These responses entail turning on a ventilation system to ventilate the area where the leak occurs. The system also alerts users by making calls, emails, or notifications. In order to alert the relevant services when the gas level exceeds a predetermined threshold, this task is specifically carried out using an MQ2 sensor, calibrated to detect the level of gas present in the air, and a GMS sensor. Both of these sensors are connected to an Arduino development board.
Design & development of a prototype of the layman’s air-cooler
Authors: Ankura P.  , Vaishnavi  , Akshara  , Keerthana  , Adithya T.G.  , Pavithra G.  , Sindhu Sree M.  , T.C.Manjunath
Published: November 2022

This paper deals with the design & development of a prototype of the layman’s air-cooler. In summer seasons, we require cold water and cooled air because of scorching temperature. Modern appliances fulfilling these requirements need high power and are costly. So, we propose modified simple air cooler, which is portable and is low maintenance machine. Air cooler is one of the major consumers of electrical energy in many parts of the world today. Air cooler causes energy shortage for example
in China. The demand can be expected to increase because of changing working times increased comfort expectations and global warming. Air conditioners are pretty expensive themselves and adding to them their power bills makes it out of reach for most common man. So opting for an air cooler is probably one solution which not only is cheaper as an appliance, but also uses lower power than conventional air conditioners. The work presented here is the mini-project work of the second semester engineering students of electronics & communication engineering department of Dayananda Sagar College of Engg., Bangalore, Karnataka
Re-construir a esperança nos pais do doente crónico em estado critico
Authors: Neto Elisabete Fernandes , Alves Rosa Maria Moreira
Published: November 2022

O objetivo deste trabalho é refletir acerca da Esperança dos pais do doente crónico, em estado crítico, internado na Unidade de Cuidados Intensivos Pediátricos (UCIP) do Centro Hospitalar Universitário de S. João (CHUSJ), com o intuito de contribuir para a sistematização das intervenções promotoras de esperança. Desta forma, melhorar a forma como os enfermeiros apoiam os pais do doente crónico em fase crítica. A metodologia utilizada foi uma Pesquisa bibliográfica e análise reflexiva dos cuidados promotores da esperança aos pais da criança crónica em estado crítico promovidos na UCIP. A observação, a experiência e sobretudo a reflexão sobre os nossos próprios atos é a melhor forma de aprendizagem e evolução. Desta forma a análise reflexiva da nossa prática à luz de uma teoria tornou-se sem dúvida num momento privilegiado que contribuiu para o nosso crescimento pessoal e profissional. A admissão de uma criança com doença crónica em estado crítico, nos cuidados intensivos pediátricos, surge como uma ameaça à esperança dos pais. Baseado nos princípios promotores da esperança, a Equipa de enfermagem da UCIP do CHUSJ, desenvolve a Esperança no binómio criança/família, pretendendo-se sistematizar essas intervenções no cuidar em Enfermagem.
Digital Tools for the Development of the Hospitality and Tourism Industry in the Context of a Digitized Economy
Authors: Verhun Antonina
Published: November 2022

Digital technologies are an important part of the hotel and tourism industry, which are driving its rapid development. The aim of this article is to investigate the main trends in the use of digital tools in the development of the hotel and tourism digital industry. The results demonstrate several key trends in the use of digital tools for the development of the hospitality and tourism digital industry. A key trend of the hospitality industry is self-booking and travel arrangements made by tourists, in particular through online agencies. Thus the needs of consumers in the hospitality and travel industry have contributed to the development of new technological solutions. This has led to increased digitalisation of the travel and hospitality industry as a component of the digital economy. The next important trend is the growth of the online travel market (e-commerce sites and sightseeing sites). Among the key areas of digital tools for the hospitality and travel industry are: digital marketing in the travel industry; digital presence of companies through travel websites; digital presence of consumers through online travel search, online booking and travel planning technologies; social media. Cloud computing and big data, blockchain and travel apps are among the most used technologies in the hospitality and travel industry. It is these digital tools that allow users to book travel services themselves (hotel reservations, travel bookings, ticket purchases, short-term rentals, etc.).
Foreign Experience of State Regulation of Agricultural Production
Authors: Halkin Vasyl
Published: November 2022

Providing the population with food is one of the main tasks of the system of state regulation of production. Food security plays an important role in socio-political and socio-economic processes. The United Nations, in particular the World Food Program, identify the problem of providing food for the global population as critical, especially in the poorest countries of the world. The issue of hunger and malnutrition, including among ideas, is defined as a global issue of humanity, and the fight against hunger has become one of the goals of sustainable development, defined by the UN Sustainable Development Concept. Global issues belong to the sphere of influence of state authorities, that is, state regulation has a decisive role in the system of providing the population with food. The article conducts a literary analysis of the latest research devoted to the issues of food security and the creation of conditions for the effective development of agriculture as the basis of food security of countries, regions, and the planet. The purpose of the article is to find effective approaches to the formation of a state regulation system of agricultural production by analyzing the world’s leading experience. By accumulating leading world experience, problematic aspects of the research were determined. The development of effective ways of agricultural development and the solution of problems with providing food to the population can be ensured by analyzing the experience of the leading agricultural countries of the world in establishing a system of state regulation of agricultural production processes using intensive development methods. The article uses methods of statistical analysis, mathematical modeling, and correlation-regression analysis of the interdependence of factors of agricultural development and food supply to the population. The analysis of the existing situation in the world made it possible to prioritize the use of intensive agricultural methods as a key element of the system of state regulation of food markets.
The Role of EU Legal Regulation in the Responsibility of Private Business for the Implementation of Sustainable Development Concepts
Authors: Shekhovtsova Victoria
Published: November 2022

The study considers the mechanism of legal regulation of the practical implementation of sustainable development by private business. The main periods of implementation of this mechanism are determined and it is indicated that the practical implementation began in 2015-2017. The implementation trends were quite peaceful, without administrative pressure and legal abuses. Despite numerous scientific studies of this scientific problem, it should be noted that the implementation of EU legal requirements by international companies outside the EU legal area has not been sufficiently studied. Therefore, the purpose of the study was to assess the EU legal requirements in the development of sustainable development through the information content of financial and non-financial reporting of TNCs operating in Ukraine. The analysis of compliance with the conditions for the implementation of Directive 2014/95/EU in Ukraine is carried out. It is established that in the modern period the concept of sustainable development is realized by the management of private business structures. They realize that it is necessary to disseminate and convey information about the activities of enterprises to a wide range of society. It is noted that according to Directive 2014/95/EU, business structures do not submit financial statements in an arbitrary form, but the practice has developed three forms: Sustainability report (SR), Integrated report (IR), Corporate Social Responsibility (CSR) report. The evolution of changes in the approach to non-financial reporting is traced.
Ensuring National Security in Conditions of War: NATO’s Influence
Authors: Pogrebytskyi Mykola
Published: November 2022

The study is devoted to determining the NATO’s influence on building Ukraine’s national security in wartime. The purpose of the study is to determine the prospects for building national security with and without NATO’s participation in the conditions of war and the realities of the current military situation in Ukraine. The relevance of the study is determined by the public and government discussion points regarding the possibility of ensuring peace by the Alliance in the context of the war between Ukraine and Russia and the government’s position on finding alternative ways to ensure national security without NATO participation. General scientific methods of cognition were used to study the issue, the key of which is a critical analysis of statements of officials, politicians and officials on the formation of national security, published in the media. The study results show the current state of NATO’s cooperation with Ukraine, Ukraine’s readiness to participate in the Alliance, and the assessment of readiness by representatives of NATO member states. The discussion field is formed by statements of Ukrainian officials on alternative options for the formation of national security without NATO participation. The conclusion is made that cooperation with NATO is necessary for Ukraine, and it should be strengthened by future membership after completing a number of tasks. The practical significance of the study lies in the possibility of its use for building strategic directions for the formation of national security.
Implementation of European Experience in the Activities of Modern Domestic Enterprises of the Hospitality Industry
Authors: Peresichna Svitlana
Published: November 2022

In the context of strengthening the European integration of Ukraine, it is relevant to study the practice of functioning of the enterprises in the field of hospitality in European countries in order to form recommendations for the implementation of similar experience in domestic enterprises. The purpose of the academic paper lies in analysing the European experience of enterprises in the field of hospitality, with the aim of its implementation in the activities of domestic companies. The methodology of the research is based on the case method for the experimental study of innovative practices of the two largest hotel chains in Europe: Motel One Group and B&B Hotels. The results demonstrate a combination of concepts of customer orientation by virtue of personalized products and customer experience, with a focus on unique modern design as a key competitive advantage. Hotel chains focus on the low price segment and increase dynamically due to the advantages as follows: unique design, organic food, concentration on the main needs of customers. The activities of the hotel network correspond to the trends of the European and global market. The theoretical value of the research lies in the fact that the analysis of the cases proves that in order to implement the paradigm of “unforgettable experience”, the enterprises of the hospitality industry can concentrate on one of the parameters: entertainment, aesthetics, escapism, education. At the same time, it is possible to indirectly provide an “unforgettable experience” for customers through staff recommendations (routes, events, places of interest).
Detailed Comparative Pharmacognostical and Physicochemical Evaluation of Chirabilvadiyoga w.s.r. to Bhavana (Trituration)
Authors: Pooja Rohilla  , R N Acharya  , C.R. Harisha  , Shukla V.J  , Anshul
Published: November 2022

Chirabilvadi Yoga is a combination of four drugs Chirabilva, Arjuna, Jyotishmati and Kakanasa in powder form, each of these ingredients has solid base of previous experimental studies for their individual analgesic activity. Bhavana (trituration) is an important Samskara (process) mentioned in Ayurvedic classics by which drug may be made very potent to produce a positive results. Till date no data available on this combination Bhavita Chirabilvadi Yoga triturated seven times with Chirabilva Patra Swarasa and made dried powder. Present study is to screen the differences in pharmacognostical and pharmaceutical profile of the Chirabilvadi Yoga before and after Bhavana. After Bhavana significant changes were found in the pharmacognostical parameters like deformated rosette crystals and cluster crystal of Arjuna and broken stone cells of Arjuna, which are rarely found before Bhavana of the drug and also evaluate the differences in the pharmaceutical profile before and after Bhavana like loss on drying, ash value, acid insoluble ash, water soluble extract, methanol soluble extract, pH and HPTLC.
Analytical Study of Natakusthadi Yoga with special reference to Their Vishaghna Effects
Authors: Jina Pattanaik  , Sukeshini P Wankhede  , Sonali Chalakh
Published: November 2022

Nata & Kushta medicinal plants are easily available in Indian diaspora and both are widely used in many Agada as Vishaghna dravya mentioned in classical texts. Both have reported acetylcholinesterase and Phospholipase A2 enzyme inhibiting property in many Research studies. The quality of Nata, Kustha & Nata Kustha Yoga was evaluated based on organoleptic, physico-chemical, and microbial quality parameters. Loss on drying at 105°C, Total ash, Acid Insoluble ash, Alcohol-soluble extractive, Water-Soluble extractive, HPTLC and pH value parameters were evaluated as per WHO guidelines, Ayurvedic pharmacopoeia and Indian pharmacopoeia. Analytic analysis of Nata, Kustha & Nata Kusthadi Yoga in this study found to be under standard limit. Standardization test done on Natakusthadi Yoga helped in authenticating the preparation and in ensuring quality of the same. The Natakusthadi Yoga prepared by following standard operative procedures should have Loss on drying at 105°C, Total ash, Acid Insoluble ash, Alcohol-soluble extractive, Water-Soluble extractive and pH value is 2.1%, 4.8%, 0.32%, 42.9%, 37.8% & 5.5 respectively
Management of Lumbar Disc Herniation with Radiculopathy Through Ayurveda - A Case Study
Authors: Lekshmipriya  , P. Benedict  , M.S Deepa
Published: November 2022

Lumbar disc herniation is a major health problem, affecting the most productive population globally. It has closest resemblance with Gridhrasi mentioned in Ayurvedic classics. Treatments available in conventional sciences have limitations such as relapse of acute episodes. Here an effort was made to treat a case of L5-S1 disc extrusion with radiculopathy using a comprehensive Ayurveda treatment protocol. The protocol includes a set of treatment procedures along with certain internal medicines. Changes were analysed with the help of VAS scale, SLRT and Oswestry disability index and showed significant improvements. This case is an evidence to demonstrate the effectiveness of Ayurveda treatments in case of LDH with radiculopathy.
Manasika bhavas and roga - A biopsychosocial model
Authors: Iswarya Lekshmi J P  , Jithesh M
Published: November 2022

Ayurveda reiterates the relationship between the body and mind in its approach to health as well as illness. Though the vitiated doshas, dhatus and malas remain the physiological basis of illness, the illness itself is a more complex psychosomatic phenomenon. Ayurveda has followed biopsychosomatic approach where more emphasis is given to the aspect of integration body and mind. In somatic diseases the psychological aspect cannot be neglected, similarly in psychological diseases somatic affairs are given due consideration. Social factors also play a major role in the inter relationships, financial support etc. Modern medicine accepted the biopsychosocial approach towards health recently.  

Manasika bhavas mentioned in Ayurveda such as bhaya, krodha, soka etc., can cause or aggravate several diseases and hence there is a relation between these bhavas and roga. These manasika bhavas act as stressors as it become the cause of several diseases. Body’s response to stress has been widely studied in the branch of Psychoneuroimmunology. Recent research suggests that the mind and body share bidirectional influences, and the science of Psychoneuroimmunology identifies specific mechanisms by which these mind-body changes are mediated. Hence it is important to consider psychological factors along with biological and social factors in all diseases, assess and identify them in a timely manner so as to have effective management.
An Experimental Evaluation of humboldtia vahliana wight., a Folk Medicinal Plant on Wound Healing Action in Wistar Albino Rats-an in-vivo Study
Authors: Athira Soman  , Chandrakanth Bhat  , Hariprasad Shetty  , Sudhakar Bhat
Published: November 2022

A wound is a break in the integrity of the skin or tissues often which may be associated with disruption of the structure and function. Globally, the magnitude of acute wounds as a healthcare problem is sharply rising mainly due to industrialization. There is still a need to revisit the ancient healing methods by using traditional medicine aiming to discover a wound healing drug with better protection, rapid granulation changes, least side effects, good bio-availability and low cost. A folk medicinal plant Humboldtia vahliana Wight. belongs to the family Fabaceae, is a medium sized tree with rough, dark brown bark mottled with white. Its stem bark is used for wound healing among the tribes. Aims and objectives: The study aims to evaluate the in-vivo wound healing action of Humboldtia vahliana Wight. through excision and incision animal wound models. Methodology: 36 male Wistar albino rats weighing 150-250gm. were selected and made into 3 groups each for both incision and excision wounds, i.e., control, standard and trial group -each containing 6 rats. The trial drug Humboldtia vahliana Wight. was applied over the wound area in the form of ‘Kalka’. In excision wound model, percentage of wound contraction was the parameter for the study and was achieved by using Planimetry. In incision wound model, tensile strength was the parameter and was achieved by Local Tensiometer. Results: In case of both Incision as well as Excision wound contraction study, the data shows a statistically non-significant increase in percentage wound contraction of Trial group when compared to Control and Standard groups. Interpretation and Conclusion: The stem bark of Humboldtia vahliana Wight. showed better wound healing action in Wistar albino rats when percentage of efficacy or mean values were compared
Land Resource Inventory for Evaluation of Land Capability and Land Use Planning in Palakkad District of Kerala State using Remote Sensing and GIS Techniques
Authors:   Soil and Landuse Survey of India, IARI Building, New Delhi-110 012, William Mariya Joseph A. , Meena R. L. ,   Soil and Landuse Survey of India, IARI Building, New Delhi-110 012, Arya V. S. ,   Soil and Landuse Survey of India, IARI Building, New Delhi-110 012
Published: November 2022

Land resource inventory was carried out in Palakkad District using remote sensing, GIS and GPS technologies. IRS- ID, LISS-III Satellite imageries were used to delineate different soil units based on image characteristics and was correlated with the different landforms. A standard soil survey methodology was followed to prepare soil resources map of the area. The inherent soil properties as an internal attributes and topography, physiographic unit, slope and climate as an external land feature of each mapping unit were evaluated for their capability occuring. It was found that soils developed on valleys and pediplain covered an area of 45.7 per cent under agriculture and plantation crops and have been classified in Land capability class II and III. Soils of foothill slope and pediment constituting 5.7 per cent of the area were classified in class III and IV and covered by plantation and open scrub. Soils of hill side slope covered an area of 8.8 per cent and classified under class VI and VII with plantation and open scrub. Reserve Forest area which constitutes 29.1 percent was not grouped as per capability classification criteria. The study indicated that Physical, chemical and biological phenomenon occur in natural habitat and conservation processes play a decisive role and should be considered for designing proper Land use planning aimed at the effective utilization of land according to their classes.
Ensemble of Bio-inspired Algorithm with Statistical Measures for Feature Selection to Design a Flow-Based Intrusion Detection System
Authors: Rahul Adhao  , Vinod Pachghare
Published: November 2022

In today's high-speed network, the existing Intrusion Detection System (IDS) approaches experience more false alarm rates with low detection capability. Nowadays, IDS needs to analyze a considerable amount of data. The larger the amount of data results in the longer the time to analyze it, which delays attack detection. The IDS usability is defined as its capability to trigger an alarm early enough to minimize the damage that an ongoing attack can cause and provide a reduced range of warning (false alarm). These underline the necessity of feature selection in IDS to identify the informative features and overlook the irrelevant or redundant features that affect the IDS's detection rate and computational complexity. It implies that anticipating an ideal number of features from a flow-based intrusion dataset can improve IDS accuracy. Therefore, this paper proposes an ensemble of a bio-inspired algorithm (Krill Herd Algorithm) with statistical measures (Information Gain) to select optimal features for a flow-based IDS. This ensemble technique has shown improvement in the detection rate, decreases the false alarm rate, and reduces the computation time of the IDS.
Comprehensive Review on Deep Learning Algorithms for Wind Power Prediction
Authors: Geetika Sharma  , Madan Lal  , Kanwal Preet Singh Attwal
Published: November 2022

In recent years, various energy crisis and environmental considerations have prompted the use of renewable energy resources. Renewable energy resources like solar, wind, hydro, biomass, etc. have been a continuous source of clean energy. Wind energy is one of the renewable energy resources that has been widely used all over the world. The wind power is mainly dependent on wind speed which is a random variable and its unpredictable behavior creates various challenges for wind farm operators like energy dispatching and system scheduling. Hence, predicting wind power energy becomes crucial. This        has led to the development of various forecasting models in the recent decades. The most commonly used deep learning algorithms for wind power prediction are- RNN (Recurrent Neural Network), LSTM (Long Short- Term Memory) and CNN (Convolutional Neural Network). This paper presents the working of these algorithms and provides a timeline review of the research papers that used these algorithms for wind power prediction.
Lead Production in Morocco at the Zellidja Lead Smelter Company
Authors:   Laboratory of Applied Geosciences, Faculty of Sciences, Mohammed First University, BV Mohammed VI, P.O. Box 524, 60000 Oujda, Morocco, Moussaoui Raja
Published: November 2022

The subsoil of Morocco is marked by a wealth of mineral resources (phosphate, lead, zinc, coal and others). For this reason, the mining sector is still considered one of the main pillars of the national economy. The Moroccan lead deposits are located mainly in the Atlas region and the Eastern region. The Zellidja lead smelter company has succeeded in distinguishing itself and being among the best lead smelters in Morocco. It is known nationally and internationally for its production of soft lead, antimonial lead oxide, fine silver, copper matte and triple alloy concentrate. The majority of its production is destined for international markets such as Europe, North Africa, Near East and Middle East. In addition, it is also recognized for its large capacity of processing lead concentrate from several mines. This capacity has obviously increased and decreased over time, depending on the number of mines exploited, the presence or absence of ore, the quality of the industrial equipment, the number of employees and other circumstances.
Implementation Government Regulations Number 31 of 2019 Accelerates Halal Product of Indonesian Excelled on the World Stage
Authors:   Lecturer in Islamic Economics at the Faculty of Islamic Economics and Business, Jember State Islamic Institute, Chotib Moch. , Eri Safira Martha ,   Law Lecturer at the Faculty of Sharia, Ponorogo State Islamic Institute, Maulidia Rohmah ,   Lecturer in Islamic Economic Law at the Sharia Faculty of the Ponorogo State Islamic Institute
Published: November 2022

Many developed countries with a majority of non-Muslim population have advanced to introduce the country as a country supporting halal products, which are good from food products, medicines, cosmetics and tourism products. Businesses in Indonesia must learn from the majority of non-Muslim countries such as Thailand, South Korea, Mexico, Japan and Spain. Demographically the Muslim population in the country is relatively minimal, but the awareness of businesses towards the needs of the global industry is very high. Lately, halal products are considered as a very potential market. The existence of Law Number 33 of 2014 concerning Halal Product Guarantee and regulated in Government Regulation Number 31 of 2019 concerning certification of halal products, is a breath of fresh air for the acceleration of halal products in Indonesia to be able to compete on the world stage. Indonesia has natural diversity that can be promoted for halal and cultural tourism with a variety of foods and tastes manifested in a variety of typical snacks products that number in the thousands. Referring to BPS data, the food and beverage industry is one of the reliable manufacturing sectors. The important role of this strategic sector can be seen from its consistent and significant contribution to Gross Domestic Product (GDP) over the past five years. This number is predicted to increase along with the awareness of business actors to register their halal legalization. This study aims to see the Indonesian people have legal awareness to use halal products to support the halal industry in Indonesia and see the awareness of businesses in Indonesia that halal products in the industrial era 4.0 is now a must. With the PP No. 31 of 2019 apparently not all business operators in Indonesia have registered their products to have halal label certification.
Achievement Goal Orientation, and Self-Regulated Learning Strategy as Correlates of Students’ Academic Achievement in English Language in Anambra State, Nigeria
Authors:   Department of Educational Foundations Faculty of Education, Nnamdi Azikiwe University Awka Anambra State, Adeline Nne Anyanwu , Elizabeth EzenwosuNgozi , Kingsley Ekene Emesi ,   Department of Educational Foundations Faculty of Education, Nnamdi Azikiwe University Awka Anambra State,   Department of Educational Foundations Faculty of Education, Nnamdi Azikiwe University Awka Anambra State
Published: November 2022

Students’ achievement goal orientation and self-regulated learning strategies are strong indicators and facilitators of proactive learning. The study aimed to explore the relationship among students’ achievement goal orientation, self-regulated learning strategies and academic achievement in Anambra State. Six research questions and six null hypotheses guided the study. The study adopted a correlation approach to provide answers to the research questions. The population of the study comprised of 21,204 SS II students from which a sample of 630 was drawn. Multi-stage procedure was used to select the sample. Two standardized research instruments namely; Achievement Goal Orientation Questionnaire (AGOQ), and Motivated Strategies for Learning Questionnaire (MSLQ), as well as score from students’ promotional examination were used for data collection. Cronbach’s alpha was used to determine the reliability of the items in the instruments. Reliability indices of 0.73, for masteryapproach, 0.71, for mastery-avoidance, 0.82, for performance-approach, 0.76, for performance-avoidance, 0.72 for workavoidance, 0.64 for monitoring, 0.73 for planning, and 0.68 for self-regulating activity respectively. The overall reliability coefficient was 0.71 which shows that the instrument was reliable and good for the study. The Pearson Product Moment Correlation was used to answer research questions 1 to 5 and hypotheses 1-5 while the research question 6 and null hypothesis 6 were answered with multiple correlation. Findings showed that students’ recorded a very low positive and significant relationship between students’ mastery-approach and their academic achievement in English language. Findings also revealed that the multiple correlations of these variables is positive and significant with academic achievement in English language. Finally, it was recommended based on the low relationship recorded between students’ achievement goal orientation and self-regulated learning strategy that students should consider these variables as useful academic facilitators that could enable them achieve their core values in the learning exploration.
Confidence, Motivation, and Anxiety; Does it Affect the Performance of Basketball Athletes?
Authors:   Department of Sport Science, Yogyakarta State University, Yogyakarta Indonesia, Rinaldy Muh. , Suherman Wawan S. ,   Department of Sport Science, Yogyakarta State University, Yogyakarta Indonesia, Arianto Afeb Chesa ,   Department of Sport Science, Yogyakarta State University, Yogyakarta Indonesia, Ayudi Andrian Rahman ,   Department of Sport Science, Yogyakarta State University, Yogyakarta Indonesia, Hartanto Amri ,   Department of Sport Science, Yogyakarta State University, Yogyakarta Indonesia
Published: November 2022

This study aims to analyze the effect of self-confidence, motivation, and anxiety on the performance of basketball athletes. This type of research is quantitative with an ex post facto approach. The population in this study were high school basketball athletes in Baubau City, totaling 119 people (68 male, 51 female). The instrument used is a questionnaire. The data analysis technique used the F test. The results showed that (1) there was a positive effect of self-confidence on competitive performance in high school basketball athletes in Baubau City. (2) there is a positive motivational effect on competitive performance in high school basketball athletes in Baubau City. (3) there is a negative effect on match performance on high school basketball athletes in Baubau City. (4) There is an effect of self-confidence, motivation and anxiety on the competitive performance of high school basketball athletes in Baubau City.
Metformin Inhibits Cisplatin-Induced Epithelial-to-Mesenchymal Transition in Chemoresistant Ovarian Cancer by Repressing Akt Signaling
Authors:   Department of Gynecology and Obstetrics, Ningxia People’s Hospital, Yinchuan, China, Han Xuechuan , Yu Yan ,   Department of Gynecology and Obstetrics, Ningxia People’s Hospital, Yinchuan, China
Published: November 2022

Objective: The aim of this study was to investigate the role of metformin in reversing the chemoresistance of ovarian cancer and the underlying mechanism. Material and Methods: The expression of E-cadherin、 vimentin and p-Akt in A2780 and A2780/DDP cells was determined by Western blot. The regulatory effects of metformin on proliferative and apoptosis in A2780/DDP cells were evaluated by the Cell Counting Kit 8 (CCK-8) and the Annexin V-FITC Kit. The expression of E-cadherin、vimentin and p-Akt in different groups of A2780/DDP cells was determined by Western blot. Results: The expression levels of E-cadherin were significantly lower in A2780/DDP cells than in A2780 cells (p<0.05); in contrast, the expression levels of vimentin and p-Akt were significantly higher (p<0.05). The combination of metformin and cisplatin reduced cell viability compared with cisplatin treatment only. However, the combination of cisplatin and metformin had no effect on apoptosis in A2780/DDP cells. In addition, cisplatin was shown to induce EMT in A2780/DDP cells (p<0.05), while the combination of metformin and cisplatin reversed EMT. Cisplatin was also shown to increase the expression levels of p-Akt in A2780/DDP cells (p<0.05), while the combination of metformin and cisplatin reversed the expression of p-Akt. Conclusion: Metformin can sensitize A2780/DDP cells to cisplatin by inhibiting EMT. We hypothesize that the mechanism responsible for this effect involves the inhibition of the Akt signaling pathway
Perspectives on cybersecurity and cyber defense in Latin America
Authors: Pavón Estefanía , Guaytarilla Luis Fernando , Cueva Christian , Durango Karla
Published: November 2022

This article presents a bibliographical review dealing with the aspect of cyber security and cyber defense in Latin American countries. It highlights the large scale that cyber-attacks currently have, the measures taken by the governments of the countries, and the prospects for improving cyber security in Latin American countries. This work is based on a systematic review of articles on aspects of cyber security and cyber defense drawn from specialized databases on computer advances and military developments. It is concluded that the large technological gap between Latin American countries compared to other countries in North America and Europe is an important factor and must be urgently reduced to avoid compromising the integrity of nations and their interests.
NEW GRADUATE NURSE'S MEDICATIONS EXPERIENCE BASED ON BENNER'S MODEL OF CLINICAL COMPETENCY AT KSA
Authors: Shereen Ahmed Ahmed Qalawa
Published: November 2022

Nursing competence is a life-threatening factor that is directly related to improved and positive patient consequences. A main intention in Benner’s from beginner to expert model, competence is a continuous procedure of getting information, practice, and experience. Aim: Explore the medication experience among new graduate nurse's based on Benner's model of clinical competency at Qassim University, king Saudi Arabia. Subject and methods: A descriptive exploratory research design on 104 graduates nurses from Qassim university. One tool is divided into two main parts; demographic data, and Medication's competency and experience assessment sheet . Results: There are nearly two-third of graduate's nurses (72.1%) have a high level of medications experience competency. There are a statistically significant relation was found between graduate's medications experience with their socio-demographic characteristics except in the item related to position of their graduate's or internship. There are a statistically significant relation was found between graduate's nurses medications experience with their competency level in all items as they assigned to drug calculation before administered drugs , experience administration of hazard medications ps=(0.001) except the item related they faced drug injury during their work Ps= (0.342) . Conclusion &recommendations: half of graduates strongly agree on that nurse mentors have had an important role in their learning of medication administrations. Additionally, there are nearly two-third of graduate's nurses have a high level of medications experience competency. However , there are a statistically significant relation was found between graduate's medications experience with their socio-demographic characteristics except in the item related to position of their graduate's or internship. Additionally , there are a statistically significant relation was found between graduate's nurses medications experience with their competency level in all items as they assigned to drug calculation before administered drugs , experience administration of hazard medications except the item related they faced drug injury during their work . Graduates nurses need for receive regular; periodic in-service program contains methods of drug calculation and how to prevent medication errors. Further studies are needed to study the factors that influence graduate's nurses' medication competency.
Nanonized progesterone formulation for improved oral bioavailability in healthy and pregnant rabbits
Authors: Gaurav K Jain  , Jagriti Sharma  , Nimesh Modi  , Tejas Kothari  , Nazeer Hasan  , Nitin Sharma  , Amirhossein Sahebkar  , Prashant Kesharwani
Published: November 2022

The aim of this study is to evaluate and compare the oral bioavailability of nanonized progesterone (nano-PG) and micronized progesterone (micro-PG) sustained release tablet formulation in healthy and pregnant rabbits. High pressure compressed gas technology reduces the particle size from 1.72 ± 2.5 μm (micro-PG) to 800 ± 35 nm (nano-PG). DSC and XRD showed that both micro-PG and nano-PG were crystalline and exist as form I. Higher melting enthalpy of nano-PG indicated improved drug stability whereas XRD showed slight reduction in degree of crystallanity following nanonization. Nano-PG demonstrated 2-fold higher solubility in SDS aqueous solution and significantly higher permeability (p < 0.05) across porcine intestine compared to micro-PG. The pharmacokinetics of nano-PG and micro-PG was conducted in healthy and pregnant rabbits. The Cmax of nano-PG was higher in healthy and pregnant rabbits however the difference was significant in healthy rabbits only. The nano-PG demonstrated 30% and 18% higher bioavailability compared to micro-PG in healthy and pregnant rabbits, respectively. In conclusion, nanonization improves solubility, dissolution and bioavailability of PG in rabbits without affecting solid state characters.
Risk of social media and computer games on physical and health well-being of children and their parents
Authors: Samah El Awady Bassam  , Shereen Ahmed AhmedQalawa
Published: November 2022

Social media use