bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1, Figure 1 - 4 from FOXL1, a Novel Candidate Tumor Suppressor, Inhibits Tumor Aggressiveness and Predicts Outcome in Human Pancreatic Cancer
Authors: Zhang Geng , He Peijun , Gaedcke Jochen , Ghadimi B. Michael , Ried Thomas , Yfantis Harris G. , Lee Dong H. , Hanna Nader , Alexander H. Richard , Hussain S. Perwez
Published: April 2023

PDF file - 612K, Table S1. Characteristics of patient population. Figure S1. An inverse association between FOXL1 and ZEB1 expressions in pancreatic cancer cell lines. Figure S2. Oncomine analysis on differential expression of FOXL1 in multiple publicly available microarray datasets of pancreatic cancer. Figure S3. The effect of silencing FOXL1 by siRNA on cell growth, apoptosis and invasion in pancreatic cancer cells. Figure S4. The regulation of apoptosis-related gene expression by overexpression of FOXL1 in Panc1 cells.
Supplementary Figure 2 from RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia
Authors: Schmiedel Benjamin Joachim , Scheible Carolin Andrea , Nuebling Tina , Kopp Hans-Georg , Wirths Stefan , Azuma Miyuki , Schneider Pascal , Jung Gundram , Grosse-Hovest Ludger , Salih Helmut Rainer
Published: April 2023

PDF file - 264K, (A) The ability of MM cells to release sRANKL does not influence NK reactivity induced by RANK-Fc-ADCC. The increase in cytotoxicity (left) and cytokine production (right) of allogeneic NK cells using RANKL surface-positive MM cells that do (+sRANKL) or do not (-sRANKL) release sRANKL as targets upon treatment with RANK-Fc-ADCC was calculated. To this end, specific lysis (E:T ratio 40:1) or cytokine release (E:T ratio 1:1) of NK cells in the presence of isotyp control-treated target cells was set to 1 in each individual data set. No statistically significant difference (p=0.39 and p=1, respectively; Mann-Whitney U-Test) was observed upon analysis of results from 8 (cytotoxicity) and 6 (cytokine release) independent experiments. (B) Surface levels of RANKL do not correlate with induction of NK reactivity by RANK-Fc-ADCC. Expression of RANKL on patient MM (circles) and CLL cells (triangles) was correlated with the increase in cytotoxicity (left) and cytokine production (right) of allogeneic NK cells upon treatment with RANK-Fc-ADCC calculated by as described in A. Each symbol represents the result of one independent experiment. The number of independent experiments, correlation coefficients (Pearson correlation) and p values (T-Test) are indicated. (C) NK reactivity against RANKL surface-negative MM cells is not affected by the fusion proteins. RPMI 8226 MM cells (left) and primary MM cells (right) that lack RANKL surface expression were incubated with allogeneic NK cells in the presence or absence of 10mug/ml of the indicated RANK fusion proteins or isotype control. Cytotoxicity was determined by 2h Europium release assays (upper panels) and IFN-gamma levels in supernatants were analyzed after 24h by ELISA (lower panels). (D) RANKL transfectants were cultured with allogeneic NK cells in the presence or absence of RANK-Fc-ADCC or isotype control (10�g/ml each) and the indicated concentrations of rRANKL. Cytotoxicity was determined by 2h Europium release assays (left) and IFN-� levels in supernatants were analyzed after 24h by ELISA (right). One repesentative experiment each of a total of three with similar results is shown in C and D.
Supplementary Figure 6 from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 153K, Inhibition of b-catenin signalling impacts on proliferative and transcriptional properties of basal breast cancer line.
Supplementary Figure Legend from Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network
Authors: Vera Julio , Schmitz Ulf , Lai Xin , Engelmann David , Khan Faiz M. , Wolkenhauer Olaf , Pützer Brigitte M.
Published: April 2023

PDF file - 93K
Supplementary Data from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

Supplementary Data PDF file 168K, Supplementary Materials and Methods; Supplementary Figure and Table Legends
Supplementary Table 2 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 58K, Sequences and concentrations of the primers used to detect human and murine genes expression by qPCR.
Supplementary Materials and Methods from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 89K.
Supplementary Figure 2 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 294KB, Mitotic and post-mitotic abnormalities induced by the lack of Aurora-A in mouse fibroblasts and tumors.
Supplementary Figures 1 - 7 from Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis
Authors: Baker Ann-Marie , Bird Demelza , Welti Jonathan C. , Gourlaouen Morgane , Lang Georgina , Murray Graeme I. , Reynolds Andrew R. , Cox Thomas R. , Erler Janine T.
Published: April 2023

PDF file - 574K, Endomucin staining in HT29 and LS174T subcutaneous tumors (S1); VEGF transcription and secretion in HT29 and LS174T cell lines and subcutaneous tumors (S2); Dependence of VEGF transcription and secretion on Akt(Ser473) phosphorylation (S3); Phosphorylation of PDGFRβ in response to LOX, and effect of PDGFRβ inhibition on VEGF transcription (S4); Effect of VEGF signaling inhibition on LOX-stimulated endothelial cell wound closure and sprouting (S5); In vivo sponge assay using SW620 conditioned media, and VEGF and CD31 immunostaining in a tissue microarray of patient samples (S6); Validation in the 4T1 breast cancer model (S7)
Supplementary Figure 4 from MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis
Authors: Ho Ming-Yi , Liang Shu-Mei , Hung Shao-Wen , Liang Chi-Ming
Published: April 2023

PDF file - 171K, MIG-7 protein sustains phosphorylation of Akt and GSK-3beta in PGE2-treated human lung cancer cells
supplementary Figure Legends 1-2 from Dose-Dense Chemotherapy Improves Mechanisms of Antitumor Immune Response
Authors: Chang Chih-Long , Hsu Yun-Ting , Wu Chao-Chih , Lai Yan-Zen , Wang Connie , Yang Yuh-Cheng , Wu T.-C. , Hung Chien-Fu
Published: April 2023

PDF file - 88K, Supplemental figure legends detailing the effectiveness of dose dense treatment compared to maximum tolerated dose treatment in the context of single chemotherapeutic agents and a platinum-resistant tumor model
Supplementary Table 2 from PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer
Authors: Badoual Cécile , Hans Stéphane , Merillon Nathalie , Van Ryswick Cordélia , Ravel Patrice , Benhamouda Nadine , Levionnois Emeline , Nizard Mevyn , Si-Mohamed Ali , Besnier Nicolas , Gey Alain , Rotem-Yehudar Rinat , Pere Hélène , Tran Thi , Guerin Coralie L. , Chauvat Anne , Dransart Estelle , Alanio Cécile , Albert Sebastien , Barry Beatrix , Sandoval Federico , Quintin-Colonna Françoise , Bruneval Patrick , Fridman Wolf H. , Lemoine Francois M. , Oudard Stephane , Johannes Ludger , Olive Daniel , Brasnu Daniel , Tartour Eric
Published: April 2023

PDF file - 64K, List of antibodies used for immunofluorescence staining
Supplementary Methods from Cytotoxic Activity of Tivantinib (ARQ 197) Is Not Due Solely to c-MET Inhibition
Authors: Katayama Ryohei , Aoyama Aki , Yamori Takao , Qi Jie , Oh-hara Tomoko , Song Youngchul , Engelman Jeffrey A. , Fujita Naoya
Published: April 2023

PDF file - 42K
Supplementary References from EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity
Authors: Pfäffle Heike N. , Wang Meng , Gheorghiu Liliana , Ferraiolo Natalie , Greninger Patricia , Borgmann Kerstin , Settleman Jeffrey , Benes Cyril H. , Sequist Lecia V. , Zou Lee , Willers Henning
Published: April 2023

PDF file, 24K.
Supplementary Figures S1-S2 from Bone Marrow–Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer
Authors: Caiado Francisco , Carvalho Tânia , Rosa Isadora , Remédio Leonor , Costa Ana , Matos João , Heissig Beate , Yagita Hideo , Hattori Koichi , da Silva João Pereira , Fidalgo Paulo , Pereira António Dias , Dias Sérgio
Published: April 2023

PDF file - 521K, Jagged-2 expression in human cells/tissues (S1); CRC tumor diameters do not correlate with tumor or circulating CD11b+ Jag2+ cell numbers (S2)
Supplementary Table 1 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Authors: Fan Ping , Griffith Obi L. , Agboke Fadeke A. , Anur Pavana , Zou Xiaojun , McDaniel Russell E. , Creswell Karen , Kim Sung Hoon , Katzenellenbogen John A. , Gray Joe W. , Jordan V. Craig
Published: April 2023

PDF file - 59K, Sequences of Primers.
Supplementary Figure 2 from A Classification Model for BRCA2 DNA Binding Domain Missense Variants Based on Homology-Directed Repair Activity
Authors: Guidugli Lucia , Pankratz Vernon S. , Singh Namit , Thompson James , Erding Catherine A. , Engel Christoph , Schmutzler Rita , Domchek Susan , Nathanson Katherine , Radice Paolo , Singer Christian , Tonin Patricia N. , Lindor Noralane M. , Goldgar David E. , Couch Fergus J.
Published: April 2023

PDF file - 3.9MB, Location of the non-pathogenic and intermediate variants in the mouse BRCA2-DSS1-ssDNA complex
Supplementary Figure 2 from Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Authors: Wegiel Barbara , Gallo David , Csizmadia Eva , Harris Clair , Belcher John , Vercellotti Gregory M. , Penacho Nuno , Seth Pankaj , Sukhatme Vikas , Ahmed Asif , Pandolfi Pier Paolo , Helczynski Leszek , Bjartell Anders , Persson Jenny Liao , Otterbein Leo E.
Published: April 2023

PDF file - 2219K, CO enhances DNA damage of PCa cells.
Supplementary Figure 1 from A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
Authors: Sheltzer Jason M.
Published: April 2023

PDF file - 299K, Gene Set Enrichment Analysis of aneuploidy in trisomic MEFs and karyotype heterogeneity in cancer cell lines.
Supplementary Table 3 from Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling
Authors: Schackmann Ron C.J. , Klarenbeek Sjoerd , Vlug Eva J. , Stelloo Suzan , van Amersfoort Miranda , Tenhagen Milou , Braumuller Tanya M. , Vermeulen Jeroen F. , van der Groep Petra , Peeters Ton , van der Wall Elsken , van Diest Paul J. , Jonkers Jos , Derksen Patrick W.B.
Published: April 2023

PDF - 68K, Immunohistochemistry of primary Wcre;Trp53F/F; Wcre;Ctnnd1F/+;Trp53F/F and Wcre;Ctnnd1F/F;Trp53F/F mouse mammary tumors.
Supplementary Figure 1 from Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling
Authors: Schackmann Ron C.J. , Klarenbeek Sjoerd , Vlug Eva J. , Stelloo Suzan , van Amersfoort Miranda , Tenhagen Milou , Braumuller Tanya M. , Vermeulen Jeroen F. , van der Groep Petra , Peeters Ton , van der Wall Elsken , van Diest Paul J. , Jonkers Jos , Derksen Patrick W.B.
Published: April 2023

PDF - 4445K, Comparative immunohistochemistry in human and mouse breast cancer.
Supplementary Table 2 from ETS Transcription Factor ESE1/ELF3 Orchestrates a Positive Feedback Loop That Constitutively Activates NF-κB and Drives Prostate Cancer Progression
Authors: Longoni Nicole , Sarti Manuela , Albino Domenico , Civenni Gianluca , Malek Anastasia , Ortelli Erica , Pinton Sandra , Mello-Grand Maurizia , Ostano Paola , D'Ambrosio Gioacchino , Sessa Fausto , Garcia-Escudero Ramon , Thalmann George N. , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

XLSX file - 2556K, Genes induced in 22RV1ESE1 vs 22RV1control.
Supplementary Table 1 from ETS Transcription Factor ESE1/ELF3 Orchestrates a Positive Feedback Loop That Constitutively Activates NF-κB and Drives Prostate Cancer Progression
Authors: Longoni Nicole , Sarti Manuela , Albino Domenico , Civenni Gianluca , Malek Anastasia , Ortelli Erica , Pinton Sandra , Mello-Grand Maurizia , Ostano Paola , D'Ambrosio Gioacchino , Sessa Fausto , Garcia-Escudero Ramon , Thalmann George N. , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

PDF file - 65K, Primer sets for RT-PCR, qRT-PCR and ChIP.
Supplementary Table 8 from A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models
Authors: Zhang Xiaomei , Claerhout Sofie , Prat Aleix , Dobrolecki Lacey E. , Petrovic Ivana , Lai Qing , Landis Melissa D. , Wiechmann Lisa , Schiff Rachel , Giuliano Mario , Wong Helen , Fuqua Suzanne W. , Contreras Alejandro , Gutierrez Carolina , Huang Jian , Mao Sufeng , Pavlick Anne C. , Froehlich Amber M. , Wu Meng-Fen , Tsimelzon Anna , Hilsenbeck Susan G. , Chen Edward S. , Zuloaga Pavel , Shaw Chad A. , Rimawi Mothaffar F. , Perou Charles M. , Mills Gordon B. , Chang Jenny C. , Lewis Michael T.
Published: April 2023

Supplementary Table 8 � XLXS file 12K, Sequenom assays used
Supplementary Methods and Figure Legends from Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics
Authors: Luo Ming , Zhao Xiaofeng , Chen Song , Liu Suling , Wicha Max S. , Guan Jun-Lin
Published: April 2023

PDF file, 140K.
Supplementary Fig 2 from A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models
Authors: Zhang Xiaomei , Claerhout Sofie , Prat Aleix , Dobrolecki Lacey E. , Petrovic Ivana , Lai Qing , Landis Melissa D. , Wiechmann Lisa , Schiff Rachel , Giuliano Mario , Wong Helen , Fuqua Suzanne W. , Contreras Alejandro , Gutierrez Carolina , Huang Jian , Mao Sufeng , Pavlick Anne C. , Froehlich Amber M. , Wu Meng-Fen , Tsimelzon Anna , Hilsenbeck Susan G. , Chen Edward S. , Zuloaga Pavel , Shaw Chad A. , Rimawi Mothaffar F. , Perou Charles M. , Mills Gordon B. , Chang Jenny C. , Lewis Michael T.
Published: April 2023

Supplementary Fig 2 � PDF file 783K, Histology of unmatched xenograft lines
Supplementary Table 1 from eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes
Authors: Yang Jianling , Wang Jun , Chen Ke , Guo Guijie , Xi Ruijiao , Rothman Paul B. , Whitten Douglas , Zhang Lianfeng , Huang Shile , Chen Ji-Long
Published: April 2023

PDF - 50K, Mass spectrometry assay.
Supplementary Figure 8 from Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer
Authors: Sawant Anandi , Deshane Jessy , Jules Joel , Lee Carnella M. , Harris Brittney A. , Feng Xu , Ponnazhagan Selvarangan
Published: April 2023

PDF file - 169K, MDSC(+bone mets) from gemcitabine treated mice failed to differentiate into osteoclasts
Supplementary Materials and Methods from eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes
Authors: Yang Jianling , Wang Jun , Chen Ke , Guo Guijie , Xi Ruijiao , Rothman Paul B. , Whitten Douglas , Zhang Lianfeng , Huang Shile , Chen Ji-Long
Published: April 2023

PDF - 31K, Additional experimental procedures including DNA construction, mass spectrometry analysis, and data regarding antibodies and reagents.
Supplementary Figure 5 from Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer
Authors: Sawant Anandi , Deshane Jessy , Jules Joel , Lee Carnella M. , Harris Brittney A. , Feng Xu , Ponnazhagan Selvarangan
Published: April 2023

PDF file - 103K, Nitric oxide levels are elevated in MDSC(+bone mets) as they differentiated into osteoclasts
Supplementary Table 1 from Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924
Authors: Blank Jonathan L. , Liu Xiaozhen J. , Cosmopoulos Katherine , Bouck David C. , Garcia Khristofer , Bernard Hugues , Tayber Olga , Hather Greg , Liu Ray , Narayanan Usha , Milhollen Michael A. , Lightcap Eric S.
Published: April 2023

XLS file - 4.1MB, Summary of Genome-wide siRNA Screen
Supplementary Figures from Infiltrating Macrophages Promote Prostate Tumorigenesis via Modulating Androgen Receptor-Mediated CCL4–STAT3 Signaling
Authors: Fang Lei-Ya , Izumi Kouji , Lai Kuo-Pao , Liang Liang , Li Lei , Miyamoto Hiroshi , Lin Wen-Jye , Chang Chawnshang
Published: April 2023

PDF file, 1659K, S1. Effects of THP-1 on cell migration, acinar morphogenesis, and downstream signaling in BPH-1 cells. S2. H&E staining of the anterior prostate from athymic nude mice 60 days after orthoptoic injection of either THP-1 or RWPE-1 cells. S3. Elevated pSTAT3 in mouse prostate epithelial cells (mPrE) after co-culture with mouse macrophages. S4. THP-1 cells were cultured alone for 48 hrs, and the expressions of cytokines were determined by a human cytokine array (R&D Systems). S5. qPCR (A) and Western blot analysis (B) of p53 and PTEN expression levels in RWPE-1 cells and RWPE-1/THP-1 cells after long term co-culture for 5 days. S6. The role of CCL4 and macrophage AR in the modulation of EMT markers and CCR1 expression in RWPE-1 cells. S7. Effects of macrophages AR silencing on BPH-1 cells during co-culture. S8. Generation and confirmation of MARKO/PTEN+/- mice. S9. CCL4 expression in prostate cancer does not associate with pathologic stage, lymph node metastasis, and recurrent-free survival. S10. IHC Staining of Mouse PTEN knockout prostate using an anti-Snail antibody.
Supplementary Materials and Methods and Figures 1-3 from Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab
Authors: Goéré Diane , Flament Caroline , Rusakiewicz Sylvie , Poirier-Colame Vichnou , Kepp Oliver , Martins Isabelle , Pesquet Julien , Eggermont Alexander , Elias Dominique , Chaput Nathalie , Zitvogel Laurence
Published: April 2023

PDF - 115K, upplemental Figure 1. Activation of CD4+ T cells by CatmAb in mixed lymphocyte tumor cocultures. Supplemental Figure 2. Activation of CD8+ T cells by CatmAb in mixed lymphocyte tumor cocultures. Supplemental Figure 3. Activation of NK cells by CatmAb in mixed lymphocyte tumor cocultures.
Supplementary Table 3 from Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro
Authors: Henriquez Nico V. , Forshew Tim , Tatevossian Ruth , Ellis Matthew , Richard-Loendt Angela , Rogers Hazel , Jacques Thomas S. , Reitboeck Pablo Garcia , Pearce Kerra , Sheer Denise , Grundy Richard G. , Brandner Sebastian
Published: April 2023

XLSX file, 608K, Ranked gene list PNET vs. REST.
Supplementary Figure 1 from FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer
Authors: Liu Rui , Li Jingyi , Xie Ke , Zhang Tao , Lei Yunlong , Chen Yi , Zhang Lu , Huang Kai , Wang Kui , Wu Hong , Wu Min , Nice Edouard C. , Huang Canhua , Wei Yuquan
Published: April 2023

PDF file, 1512K, Co-culture with TAFs induces a stem cell-like phenotype of colorectal cancer cells.
Supplementary Material 1 from Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
Authors: Grosse Laurent , Pâquet Sophie , Caron Patrick , Fazli Ladan , Rennie Paul S. , Bélanger Alain , Barbier Olivier
Published: April 2023

PDF file - 20K, Supplementary material 1: Age, clinical stage of the disease (cT), tumor grade (Gleason score) and serum PSA from PCa sample donors.
Supplementary Video 4 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 6619K, This video shows the spatio-temporal evolution of vSkin that produced Figure 6A (normal melanocytes and mildly senescent fibroblasts).
Supplementary Video 1 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: April 2023

MOV file - 6089K, This video shows the spatio-temporal evolution of vSkin that produced Figure 3C (vSkin initialization).
Supplementary Figure 6 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 359K, NK cell mediated lysis determined by dynamic measure of cell index of adherent melanoma targets.
Supplementary Figure 4 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 437K, Characterization of the M-LN CD56bright CD16+ and CD16- NK cell subsets.
Supplementary Video 5 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: April 2023

AVI file - 1297KB, Representative endogenous TPEF OPTICAL STACK E7 EETE.
Supplementary Figure 4 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 5585K, Double staining for GFP and TGF-β detects BM-hMSCs-GFP near tumor cells expressing TGF-β in intracranial tumors.
Supplementary Materials and Methods from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: April 2023

Supplementary Materials and Methods PDF File - 113K, Supplemental materials and methods section
Supplementary Table S2 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

XLS file - 81K,Binding sites (c-MYCBSs) within the 2000bp promoter upstream of the CHK1 and CHK2 genes
Supplementary Table 1 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: April 2023

PDF file - 17K, KS culture models
Supplementary Figure Legend from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: April 2023

PDF file - 73K
Supplementary Figure 1 from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: April 2023

PDF file - 2507K, Tumors in PPwt/loxpM mice display MBEN histology, similar to PPM tumors, demonstrated by H&E staining. Scale bars represent 1 mm in the low magnification images, and 100 microm in the high magnification images.
Supplementary Figure Legends from MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Authors: Tovar Christian , Graves Bradford , Packman Kathryn , Filipovic Zoran , Xia Brian Higgins Mingxuan , Tardell Christine , Garrido Rosario , Lee Edmund , Kolinsky Kenneth , To Kwong-Him , Linn Michael , Podlaski Frank , Wovkulich Peter , Vu Binh , Vassilev Lyubomir T.
Published: April 2023

PDF file - 71K
Supplementary Data 2 from Generation of Prostate Tumor–Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling
Authors: Qu Yi , Oyan Anne Margrete , Liu Runhui , Hua Yaping , Zhang Jigang , Hovland Randi , Popa Mihaela , Liu Xiaojun , Brokstad Karl A. , Simon Ronald , Molven Anders , Lin Biaoyang , Zhang Wei-dong , McCormack Emmet , Kalland Karl-Henning , Ke Xi-Song
Published: April 2023

XLS file 35K, Chromosomal aberrations of the EPT3-M1.
Supplementary Figures from Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway
Authors: Croucher David R. , Hochgräfe Falko , Zhang Luxi , Liu Ling , Lyons Ruth J. , Rickwood Danny , Tactacan Carole M. , Browne Brigid C. , Ali Naveid , Chan Howard , Shearer Robert , Gallego-Ortega David , Saunders Darren N. , Swarbrick Alexander , Daly Roger J.
Published: April 2023

Supplementary Figures PDF file - 1342K, Supplementary Figures for Croucher et al. Supplementary Figure 1: SILAC-based (phospho)-proteomic analysis in basal breast cancer cell lines following Lyn knockdown. Supplementary Figure 2: Lyn regulates a small fraction of the SFK signaling network in basal breast cancer cells. Supplementary Figure 3: Specificity of the SgK269 pY635 antibody. Supplementary Figure 4: Effect of Lyn knockdown on protein tyrosine phosphorylation. Supplementary Figure 5: Sub-cellular location of SgK269. Supplementary Figure 6: Knockdown of Src does not affect SgK269 Y635 phosphorylation. Supplementary Figure 7: Functional role of SgK269 in MDA-MB-231 cells.
Supplemental Figure 6 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure
Supplemental Figure 2 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure 2
Supplementary Table 2 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF - 55K, miRNAs differentially expressed following T3 treatment in HepG2-TR�1.
Supplementary Figure 8 from Thyroid Hormone Regulation of miR-21 Enhances Migration and Invasion of Hepatoma
Authors: Huang Ya-Hui , Lin Yang-Hsiang , Chi Hsiang-Cheng , Liao Chen-Hsin , Liao Chia-Jung , Wu Sheng-Ming , Chen Cheng-Yi , Tseng Yi-Hsin , Tsai Chung-Ying , Lin Sheng-Yen , Hung Yu-Ting , Wang Chih-Jen , Lin Crystal D. , Lin Kwang-Huei
Published: April 2023

PDF - 144K, Schematic effects of miR-21 regulated by T3 on cell migration and invasion.
Supplementary Figure 2 from Tumor Endothelial Markers Define Novel Subsets of Cancer-Specific Circulating Endothelial Cells Associated with Antitumor Efficacy
Authors: Mehran Reza , Nilsson Monique , Khajavi Mehrdad , Du Zhiqiang , Cascone Tina , Wu Hua Kang , Cortes Andrea , Xu Li , Zurita Amado , Schier Robert , Riedel Bernhard , El-Zein Randa , Heymach John V.
Published: April 2023

PDF file - 86KB, Quantitative analysis of CTEC and CEC/CEP populations in human specimens by eight-color flow cytometry. A, Syto16 (DNA) gate used to exclude apoptotic, necrotic debris and cellular degraded fragments. Syto16-positive cells (red and blue dots) indicate all viable portions in peripheral blood mononuclear cells (PBMCs) specimen. B, P1 gate with SSC/FSC to display major blood components of the Syto16+ PBMCs (green dots). C, CD45-negative cells gated on Syto16/P1 to specifically select non-hematopoietic cells (blue dots) for further phenotypic analysis and quantitative determination. D. CD133 rectangle gate made on Syto16/P1/CD45-negative population to separate CD45-/CD133+ (pink dots) and CD45-/CD133- (blue dots) subsets. E and F, CECs/CEPs gated on Syto16/P1/CD45-/CD133+ or Syto16/P1/CD45-/CD133- subsets respectively, illustrate staining negatively or dim for hematopoietic marker CD45, positively for SYTO16 (DNA), endothelial markers CD146 and CD31, and negatively for the progenitor marker CD133 (pan dots). CEPs expressed the same phenotype as CECs except they were positively staining for CD133 (pink dots). G, Quadrant gates made on Syto16/P1/CD45- to identify the subsets expressing CD276+/CD133- (blue dots) for further phenotypic analysis and CTECs quantitative determination. H, CTECs gated on Syto16/P1/CD45-/CD133-/CD276+ demonstrate staining negatively or dim for hematopoietic marker CD45, positively for SYTO16 (DNA), tumor-derived endothelial marker CD276, endothelial markers CD146 and CD31, and negatively for the progenitor marker CD133 (aqua dots).
Supplementary Data 4 from Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Authors: Akalay Intissar , Janji Bassam , Hasmim Meriem , Noman Muhammad Zaeem , André Fabrice , De Cremoux Patricia , Bertheau Philippe , Badoual Cécile , Vielh Philippe , Larsen Annette K. , Sabbah Michèle , Tan Tuan Zea , Keira Joan Herr , Ying Hung Nicole Tsang , Thiery Jean Paul , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 160K, Data mining of microarray data showing the connections between EMT and autophagy-related genes
Supplementary Video 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Authors: Breitbach Caroline J. , Arulanandam Rozanne , De Silva Naomi , Thorne Steve H. , Patt Richard , Daneshmand Manijeh , Moon Anne , Ilkow Carolina , Burke James , Hwang Tae-Ho , Heo Jeong , Cho Mong , Chen Hannah , Angarita Fernando A. , Addison Christina , McCart J. Andrea , Bell John C. , Kirn David H.
Published: April 2023

Supplementary Video 2 MPG file - 1158K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4b (baseline; 5 days post JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic
Supplementary Table 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans
Authors: Breitbach Caroline J. , Arulanandam Rozanne , De Silva Naomi , Thorne Steve H. , Patt Richard , Daneshmand Manijeh , Moon Anne , Ilkow Carolina , Burke James , Hwang Tae-Ho , Heo Jeong , Cho Mong , Chen Hannah , Angarita Fernando A. , Addison Christina , McCart J. Andrea , Bell John C. , Kirn David H.
Published: April 2023

Supplementary Table 1 PDF file - 30K, Rabbit GLP toxicology study of intravenous JX-594
Supplementary Figure Legends from Ly49 Family Receptors Are Required for Cancer Immunosurveillance Mediated by Natural Killer Cells
Authors: Tu Megan M. , Mahmoud Ahmad Bakur , Wight Andrew , Mottashed Amelia , Bélanger Simon , Rahim Mir Munir A. , Abou-Samra Elias , Makrigiannis Andrew P.
Published: April 2023

PDF file - 203KB
Supplementary Figure 2 from Ly49 Family Receptors Are Required for Cancer Immunosurveillance Mediated by Natural Killer Cells
Authors: Tu Megan M. , Mahmoud Ahmad Bakur , Wight Andrew , Mottashed Amelia , Bélanger Simon , Rahim Mir Munir A. , Abou-Samra Elias , Makrigiannis Andrew P.
Published: April 2023

PDF file - 38KB, Lack of NKG2D ligand expression on B lymphoma cells from WT and NKCKD Eμ-mycTg mice.
Supplementary Figure 2 from Identification of Inherited Genetic Variations Influencing Prognosis in Early-Onset Breast Cancer
Authors: Rafiq Sajjad , Tapper William , Collins Andrew , Khan Sofia , Politopoulos Ioannis , Gerty Sue , Blomqvist Carl , Couch Fergus J. , Nevanlinna Heli , Liu Jianjun , Eccles Diana
Published: April 2023

PDF file - 55K, Regional plot of p-values arising from cox-proportional hazard models, 250 kb either side of the rs3884558 variant in stage-1. P-values are from imputed data alone.
Supplementary Table 4 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes
Authors: Lee Genee Y. , Haverty Peter M. , Li Li , Kljavin Noelyn M. , Bourgon Richard , Lee James , Stern Howard , Modrusan Zora , Seshagiri Somasekar , Zhang Zemin , Davis David , Stokoe David , Settleman Jeffrey , de Sauvage Frederic J. , Neve Richard M.
Published: April 2023

XLSX file - 65K, Gene Ontology analysis of gene over-expressed and amplified in the tumour samples.
Supplementary Figure 4 from NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis
Authors: Qin Li , Wu Ye-Lin , Toneff Michael J. , Li Dabing , Liao Lan , Gao Xiuhua , Bane Fiona T. , Tien Jean C.-Y. , Xu Yixiang , Feng Zhen , Yang Zhihui , Xu Yan , Theissen Sarah M. , Li Yi , Young Leonie , Xu Jianming
Published: April 2023

PDF file - 69KB, qPCR measurement of NCOA1 mRNA and mCsf1 mRNA in Tg(Neu) and Tg(NCOA1)xTg(Neu) mouse mammary gland tumor cells transfected with non-targeting control siRNA, NCOA1 siRNA, or mCsf1 siRNA.
Supplementary Methods from Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer
Authors: Maire Virginie , Némati Fariba , Richardson Marion , Vincent-Salomon Anne , Tesson Bruno , Rigaill Guillem , Gravier Eléonore , Marty-Prouvost Bérengère , De Koning Leanne , Lang Guillaume , Gentien David , Dumont Aurélie , Barillot Emmanuel , Marangoni Elisabetta , Decaudin Didier , Roman-Roman Sergio , Pierré Alain , Cruzalegui Francisco , Depil Stéphane , Tucker Gordon C. , Dubois Thierry
Published: April 2023

PDF file - 122K
Supplementary Table 1 from The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Authors: Gutschner Tony , Hämmerle Monika , Eißmann Moritz , Hsu Jeff , Kim Youngsoo , Hung Gene , Revenko Alexey , Arun Gayatri , Stentrup Marion , Groß Matthias , Zörnig Martin , MacLeod A. Robert , Spector David L. , Diederichs Sven
Published: April 2023

XLSX file - 564K, Supplementary Table S1: This table lists 459 genes that show a differential expression upon loss of MALAT1 in A549 lung cancer cells.
Supplementary Figure 2 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Authors: Russell Mike R. , Levin Kirill , Rader JulieAnn , Belcastro Lili , Li Yimei , Martinez Daniel , Pawel Bruce , Shumway Stuart D. , Maris John M. , Cole Kristina A.
Published: April 2023

PDF file - 48K, Wee1 and Chk1 expression are elevated in high-risk, MYCN-amplified neuroblastoma. Primary tumors were obtained from 251 patients at diagnosis (221 high-risk, 30 low-risk; 68 MYCN amplified, 183 MYCN non-amplified), and were run on Affymetrix Human Exon 1.0 ST expression microarrays. Both Wee1 and Chk1 expression were expressed at a significantly higher rate in both the MYCN amplified and high-risk conditions
Supplementary Methods, Figure Legend from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: April 2023

PDF file - 153K
Supplementary Figure S3 from Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy
Authors: Lim Seon Ah , Kim Tae-Jin , Lee Jung Eun , Sonn Chung Hee , Kim Kwanghee , Kim Jiyoung , Choi Jong Gwon , Choi Il-Kyu , Yun Chae-Ok , Kim Jae-Hong , Yee Cassian , Kumar Vinay , Lee Kyung-Mi
Published: April 2023

Supplementary Figure S3 PDF file - 1079K, Twenty-eight surface markers associated with activation, cytotoxicity, and differentiation were analyzed by flow cytometry on the gated NK population from the PBMC of healthy donors on Day 0 (rest, pre-activation) and Day 11 (activation, post-expansion)
Supplementary Figure Legend from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: April 2023

PDF file - 70K
Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Authors: Zhou Min , Wang Hai , Zhou Keke , Luo Xiaoying , Pan Xiaorong , Shi Bizhi , Jiang Hua , Zhang Jiqin , Li Kesang , Wang Hua-Mao , Gao Huiping , Lu Shun , Yao Ming , Mao Ying , Wang Hong-Yang , Yang Shengli , Gu Jianren , Li Chuanyuan , Li Zonghai
Published: April 2023

PDF file - 734K, Figure S1. EGFRvA is widely expressed in various cancer cell lines and tissues. Figure S2. The upregulation of EGFRvA in glioma tissues compared with paired adjacent non-neoplastic brain tissues and a poor prognosis in patients with high-grade gliomas. Figure S3. EGFRvA promotes cell migration and invasion in vitro and in vivo. Figure S4. EGFRvA caused the activation of STAT3 and increased expression of HB-EGF. Figure S5. The positive feedback regulation between HB-EGF and p-STAT3 in EGFRvA-expressing cells. Figure S6. Cell viability and cell adhesion of U87MG EGFRvA cells treated with STAT3 inhibitor AG490, and siRNA-mediated knockdown of STAT3 in U87MG transfectants. Table S1. Clinical characteristics of patients with low or high expression of EGFR or EGFRvA in 52 glioma patients. Table S2. Higher expressed genes in U87MG EGFRvA cells versus U87MG EGFR cells. Table S3. Lower expressed genes in U87MG EGFRvA cells versus U87MG EGFR cells. Table S4. Primers used in this study.
Supplementary Figure 9 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: April 2023

PDF file - 122KB, Lymphatic vessel recruitment into fibroblast-stimulated prostate and breast tumors.
Supplementary Figure S2 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: April 2023

Supplementary Figure S2 PDF File - 454K, Restoration of Arkadia activity in NCI-H460 cells does not affect cell proliferation
Supplementary Figure 2 from CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
Authors: Burkhardt Lia , Fuchs Sarah , Krohn Antje , Masser Sawinee , Mader Malte , Kluth Martina , Bachmann Frederik , Huland Hartwig , Steuber Thomas , Graefen Markus , Schlomm Thorsten , Minner Sarah , Sauter Guido , Sirma Hüseyin , Simon Ronald
Published: April 2023

PDF file - 155K, Baseline CHD1 mRNA (a) and protein (b) expression levels in prostate cancer cell lines cells. Efficacy of ectopic overexpression of CHD1 in PC-3 cells on mRNA (c) and protein level (d) by Taqman PCR and immunoblot analysis, respectively.
Supplementary Figure 6 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: April 2023

PDF file - 275KB, GDF15/MIC-1 serum levels correlate with "responder" tumor growth.
Supplementary Figure 3 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: April 2023

PDF file - 117KB, Prostate cancer cells, NIH-GDF15 fibroblasts and CAFs secrete human GDF15/MIC-1.
Supplementary Figure 2 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: April 2023

PDF file - 207KB, GDF15/MIC-1 is expressed by LNCaP prostate cancer cells and NIH-GDF15 fibroblasts.
Supplementary Methods from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: April 2023

PDF file - 128K, Supplemental materials and methods: Antibodies and reagents, apoptosis and senescence, western blot and subcellular fractionation and immunohistochemistry.
Supplementary Methods from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: April 2023

PDF file - 121K
Supplementary Figures 1 - 7, Table 1 from Moesin Is a Glioma Progression Marker That Induces Proliferation and Wnt/β-Catenin Pathway Activation via Interaction with CD44
Authors: Zhu Xiaoping , Morales Fabiana C. , Agarwal Nitin Kumar , Dogruluk Turgut , Gagea Mihai , Georgescu Maria-Magdalena
Published: April 2023

PDF file - 1179K, Figure S1. Moesin overexpression increases the global proliferation of GSC neurospheres. Figure S2. Partial moesin knockdown does not significantly change the global proliferation of GSC neurospheres. Figure S3. Characterization of the phosphorylatated P-ERM status in glioblastoma cells. Figure S4. Moesin is the main ERM protein phosphorylated in GBM cells. Figure S5. Phosphorylated moesin localizes to microspike membrane protrusion in GBM cells. Figure S6. Co-localization of endogenous and overexpressed moesin with endogenous CD44 in microspike membrane protrusions. Figure S7. Expression of ERM-NF2 proteins and stem cell markers in glioblastoma conventional cell lines and patient-derived glioblastoma stem cell neurospheres. Table S1: Genes upregulated more than 1.8 fold in Myc-Moesin-expressing cells versus control cells.
Supplementary Information from FOXP3 Regulates Sensitivity of Cancer Cells to Irradiation by Transcriptional Repression of BRCA1
Authors: Li Weiquan , Katoh Hiroto , Wang Lizhong , Yu Xiaochun , Du Zhanwen , Yan Xiaoli , Zheng Pan , Liu Yang
Published: April 2023

Supplementary Information PDF file - 849K, This figure contains 3 figures and supplementary table 3
Supplementary Table S1 and Figures S1-S8 from CDK4/6 and IGF1 Receptor Inhibitors Synergize to Suppress the Growth of p16INK4A-Deficient Pancreatic Cancers
Authors: Heilmann Andreas M. , Perera Rushika M. , Ecker Veronika , Nicolay Brandon N. , Bardeesy Nabeel , Benes Cyril H. , Dyson Nicholas J.
Published: April 2023

Supplementary Table S1 and Figures S1-S5, related to Figure 1: Supporting information on the initial analysis that lead to the study and on the synergy of IGF1R/IR and CDK4/6 inhibitors Supplementary Figure S6 and S7, related to Figure 3: Xenograft tumor staining for senescence marker H3K9me3 and pRB phosphorylation upon treatment with drug combination in vitro Supplementary Figure S8, related to Figure 6: Synergy plots for mTOR and CDK4/6 inhibitor combination
Supplementary Table S7 from Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer
Authors: Camps Jordi , Pitt Jason J. , Emons Georg , Hummon Amanda B. , Case Chanelle M. , Grade Marian , Jones Tamara L. , Nguyen Quang T. , Ghadimi B. Michael , Beissbarth Tim , Difilippantonio Michael J. , Caplen Natasha J. , Ried Thomas
Published: April 2023

Supplementary Table S7 PDF file - 300K,ist of genes in the LNX2-TCF7L2 module
Supplementary Figures 1 - 5 from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/Neu, EGF, and TNF-α in Breast Cancer
Authors: Jin Lianjin , Wessely Oliver , Marcusson Eric G. , Ivan Cristina , Calin George A. , Alahari Suresh K.
Published: April 2023

PDF file - 131K, Supplementary Figure S1. Luciferase reporter assay and expression levels of miR-23b and miR-27b and their putative targets. Supplementary Figure S2. Antisense miR-23b and miR-27b inhibited cell invasion. Supplementary Figure S3. The expression of miR-23b/27b and Nischarin in knockdown cells. Supplementary Figure S4. MEK1 inhibitor (U0126) did not affect expression of miR-23b/27b in SKBR3 cells. Supplementary Figure S5. EGF and TNF enhanced miR-23b and miR-27b expression in MDA-MB-231 cells.
Supplementary Figure Legend from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/Neu, EGF, and TNF-α in Breast Cancer
Authors: Jin Lianjin , Wessely Oliver , Marcusson Eric G. , Ivan Cristina , Calin George A. , Alahari Suresh K.
Published: April 2023

PDF file - 37K
Supplementary Figure 3 from Deficiency of Phospholipase A2 Group 7 Decreases Intestinal Polyposis and Colon Tumorigenesis in ApcMin/+ Mice
Authors: Xu Changxin , Reichert Ethan C. , Nakano Tomoyuki , Lohse Mariah , Gardner Alison A. , Revelo Mónica P. , Topham Matthew K. , Stafforini Diana M.
Published: April 2023

PDF file - 122K, Protein phosphatases PP1 and PP2 do not rescue cPAF-induced de-phosphorylation of pAkt473