bluuebunny/crossref_metadata_2025 huggingface dataset:
Praktik Botoh pada demokrasi lokal: Studi pada pemilihan Bupati Lamongan 2020
Authors: Susilowati Ana Dewi Lanjar Diwuk , Fitrianto Hari
Published: June 2024

This study examines the practice of botoh in the 2020 Lamongan regent election. The phenomenon of vote buying and the high potential for money politics in a region have triggered various practices of money politics in local elections. This research uses a descriptive qualitative approach. Data collection was carried out through in-depth interviews, with both primary and secondary data types. The aim of this study is to understand the practice and patterns of botoh in the 2020 Lamongan election and to determine how botoh influences voter preferences. The results indicate that the practice and working patterns of botoh in the 2020 Lamongan election were conducted in two ways. First, purely for material gain, involving bets among botoh practitioners. Second, as part of a candidate's campaign team, with a more systematic working mechanism. Botoh significantly influenced voter preferences in the 2020 Lamongan election, particularly in the southern region. The population in this area, classified as 'Abangan' and accustomed to the culture of money politics, was easily influenced by botoh practices.
Determining Factors for Smoking Habits and FeNO Levels in Male College Student Smokers
Authors: Tadjoedin Irfan Hasyim , Wibowo Adityo , Damayanti Triya
Published: June 2024

Introduction: Smoking remains a pervasive and persistent health issue in Indonesia. Numerous studies have explored the impact of smoking and fractional exhaled nitric oxide (FeNO) levels on college students. However, none have been conducted in Indonesia. With a substantial number of smokers and teenage smokers in the country, there is a critical need to understand the implications of smoking. This study aimed to enhance the comprehension of the motivations behind smoking habits and, consequently, to devise more effective smoking cessation programs. It specifically sought to elucidate the relationship between smoking habits and exhaled nitric oxide (NO) levels among college students and to explore the reasons why students smoke.
Methods: This study employed analytical and descriptive cross-sectional approaches. We interviewed 124 participants, 30 of whom were randomly selected for FeNO-level testing.
Results: The mean age of the subjects was 20.1 ± 1.54 years. Of these, 48 (38.7%) were enrolled in science and technology programs and 76 (61.3%) in social sciences. The Brinkman index predominantly indicated a mild level of smoking (96.8%), with a moderate level observed in 3.2% of the subjects. The median FeNO level was 12 ppb. According to the Horn questionnaire, the most cited reasons for smoking were pleasure (71%), followed by stress relief (66.1%) and stimulation (38.7%). No significant correlation was found between the Brinkman index and FeNO levels.
Conclusion: The primary factors influencing smoking habits among the subjects were stress relief and the pleasure derived from smoking. No correlation was observed between smoking habits and exhaled NO levels.
Neutrophil-Lymphocyte Ratio and Nutritional Status as Parameters of Sputum Conversion in MDR-TB Before & After 3 Months of Anti-TB Treatment
Authors: Regina Putri Maria , Silaen Johan Christian , Sembiring Susi
Published: June 2024

Introduction: The prolonged duration of tuberculosis (TB) treatment has led to an increase in non-compliance among TB patients undergoing anti-TB treatment, consequently leading to treatment failure and drug resistance, notably multidrug-resistant TB (MDR-TB). Individuals with poor nutritional status may elevate the risk of delayed sputum conversion in MDR-TB patients. The neutrophil-lymphocyte ratio (NLR) represents a laboratory parameter with potential as a prognostic indicator in patients suspected of TB infection.
Methods: This was an analytical study with a cross-sectional design. The sample was drawn from the medical records of MDR-TB patients at Haji Adam Malik General Hospital, Medan, from October 2022 to March 2023 resulting in a total of 83 samples. Data analysis was performed using Statistical Package for the Social Sciences (SPSS) version 25 software, and bivariate analysis was conducted using paired t-test.
Results: Out of 83 MDR-TB patients, 50 (60.2%) were male. Based on nutritional status before three months of anti-TB treatment, the most common nutritional status was normal with 22 individuals (26.5%) and severely underweight with 36 individuals (43.4%). Following three months of anti-TB treatment, the majority had normal, totaling 39 individuals (47%). A total of 67 individuals (80.7%) experienced sputum conversion. The results indicated a significant difference between NLR before and after three months of anti-TB treatment (p = 0.000), as well as a significant difference between nutritional status before and after three months of anti-TB treatment (p = 0.012) at Haji Adam Malik General Hospital, Medan.
Conclusion: Significant differences were observed in NLR and nutritional status before and after three months of anti-TB treatment.
D-Dimer and Brixia Score to Mortality in COVID-19 Patients
Authors: Falyani Silvy Amalia , Pratiwi Suryanti Dwi , Setyawan Ungky Agus , Erawati Dini Rachma , Djajalaksana Susanthy , Listyoko Aditya Sri
Published: June 2024

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious severe and acute respiratory syndrome caused by the SARS-CoV-2 virus. A variety of factors can increase a patient's risk of death, including coagulopathy characterized by increased D-dimer levels. Brixia scores could be one of the determinants of COVID-19 severity, as assessed by chest radiographs. This study aimed to analyze chest radiographic severity based on the Brixia score at the degree of coagulation based on D-dimer in mortality of COVID-19 patients who were hospitalized.
Methods: This cohort retrospective study was conducted at Dr. Saiful Anwar General Hospital, Malang, using an observational cross-sectional design. The study included 300 medical records of COVID-19 patients who passed away while hospitalized. The data were analyzed using the Wilcoxon test, and the results were also tested for Spearman correlation to determine the relationship between variables.
Results: Significance results of median D-dimer were found by age and severity of COVID-19 (p-values 0.015 and 0.002), and median Brixia scores by age, gender, severity of COVID-19, and length of treatment (p-values 0.001, 0.001, 0.001, and 0.005). The results were also compared with normal values, which were significant (p = 0.000). Spearman correlation test results between the final D-dimer and the initial Brixia score (p = 0.005).
Conclusion: The research results display a retrospective study of the correlation between D-dimer and Brixia score values ​​and outcomes in COVID-19 patients. Higher D-dimer values​ ​and Brixia scores on admission were shown to be associated with mortality.
SAVING COMPRESSED AIR BY CHOOSING AN EFFICIENT PNEUMATIC DRIVE CONTROL CIRCUIT
Authors: Krutikov Hennadiy , Stryzhak Mariana
Published: June 2024

The article presents the development of pneumatic circuits and control charts of pneumatic distribution valves, which make it possible to significantly expand the scope of application of power pneumatic tools to increase inertial loads and achieve a significant reduction in compressed air consumption compared to traditional throttle braking circuits with the simultaneous increase of the response speed of the pneumatic drive. A mathematical model of a pneumatic drive in a dimensionless form is obtained, and dynamic similarity criteria are highlighted. A methodology for determining the scope of efficient use of an energy-saving pneumatic drive circuits under specific operating conditions was created
TRAVELLING RESISTANCE DETERMINATION OF A BRIDGE CRANE BY STATISTICAL METHODS
Authors: Kovalenko Valentyn , Zhuravel Oleksii , Stryzhak Vsevolod , Iglin Sergii , Stryzhak Mariana
Published: June 2024

The article proposes a new approach to solving the scientific and practical problem of automating the calculation of technical parameters of general-purpose overhead cranes. The parameters of operating cranes are presented in tabular form in the form of statistical data. The hypotheses of mathematical statistics were applied, which allowed the results to be distributed according to the normal law under the assumption of equal accuracy of the data obtained. Using these assumptions, the method of least squares was applied and a function of two variables was constructed, which establishes the dependence of crane movement resistance on span and lifting capacity, combining these indicators. An expression is obtained that allows calculating the static resistance to movement by software. The advantages of the proposed approach to determining the parameters of lifting machines are shown.
JUSTIFICATION OF THE PROBLEMS OF RESEARCH OF TORSION SHAFTS OF SUSPENSION SYSTEMS OF LIGHT ARMORED VEHICLES ACCORDING TO STRENGTH AND DURABILITY CRITERIA
Authors: Zinchenko Olena
Published: June 2024

The paper shows the necessity of improving the torsion shafts of the suspension systems of light armored vehicles in order to improve their main characteristics. As a result of the analysis of the existing methods and methodologies of torsion shafts calculation, we came to the conclusion about the need to create an adequate model, which would include an assessment of the stress-strain state of the torsion shaft in different zones, taking into account many factors.
Known simplified methods for calculating the stress-strain state of torsion shafts are not suitable for the complex non-homogeneous components distribution of the stress-strain state and are a source of potential errors. Therefore, there is a need to apply the incremental flow theory, taking into account the load history of the torsion shaft material. In the work, it is proposed to reduce the problem to a sequence of problems with the breakdown of the load history into separate steps and within each step to simultaneously take into account the elastic-plastic deformation and contact interaction and their relationship and mutual influence. The necessity of generalized parametric modeling of the torsion shaft is shown, according to which the generalized parameters represent a set of distributions, functions, dependencies, structures, forms, properties, etc., which uniquely identify the torsion shaft. At the same time, this method makes it possible to purposefully change the current technical solution. All these studies will provide an opportunity to substantiate the parameters of torsion shafts in the context of improving their strength and durability.
ASSESSMENT OF VIBRATION RESISTANCE OF MOTOR-TRANSMISSION UNITS OF A VEHICLE WITH TWO INTERNAL COMBUSTION ENGINES
Authors: Podrihalo Mykhailo , Krasnokutskyi Volodymyr , Vakhniuk Serhii
Published: June 2024

The paper analyzes research on improving the energy efficiency of cars with two independent motor-transmission systems by matching the transmission parameters and engine operating modes. When using two identical powertrains, each driving the wheels of one side of the car, there is no problem of equalizing efficiency, since both engines operate in the same mode. There is also no problem with determining the part of the mass driven to the crankshaft of one engine, since the driven mass is divided in half between both engines. The problem arises when two engines are installed on a car with their own transmissions that drive different groups of axles of the car. To achieve this goal, we determined the distribution of the mass of a gradually moving vehicle between two parallel oscillating systems and the cyclic elastic efficiency of the motor-transmission system of a car with two parallel internal combustion engines controlling different groups of axles. As a result of the study, the condition for obtaining the maximum value of the elastic-dynamic cyclic efficiency of a motor-transmission system with two engines installed in parallel was determined. This condition is met due to the equality of the elastic-dynamic efficiencies of the motor-transmission systems of the first and second engines.
RATIONALISATION OF CONTINUOUSLY VARIABLE TRANSMISSION DESIGN BASED ON PRODUCTIVITY CRITERIA
Authors: Trembach Oleksiy , Kozhushko Andrii , Pelypenko Yevhen , Mamontov Anatolii , Barabash Grigorij
Published: June 2024

Today, agricultural enterprises use wheeled tractors equipped with classical stepped and continuously variable transmissions, in particular, with hydro-mechanical transmissions. The use of tractors with continuously variable transmissions is explained by undoubted advantages over step transmissions: smooth running, improved ergonomic properties during technological work, automated control, etc. During operation, farmers often need to operate at maximum productivity, while economic and environmental performance is neglected. Therefore, it is quite reasonable to introduce design changes in the transmission aimed at increasing the speed range. Therefore, the material of this article aims to provide recommendations for improving the performance of a dual-flow continuously variable transmission through a structural analysis of the operation of the hydraulic and mechanical transmission branches. To achieve this goal, the article uses a methodology that allows analysing structural changes in the size of the gearboxes located in the hydraulic and mechanical branches of the transmission, which affects the starting and maximum speed. The result is the provision of scientifically based recommendations for the influence of power flows in the hydraulic and mechanical branches of the transmission on its performance. The practical significance of the work lies in the technically sound choice of a schematic solution when placing gear ratios in transmission branches with the subsequent impact on the change in starting and maximum speed.
Antrian Pelanggan KRL di Stasiun Transit Manggarai (Jakarta)
Authors: Verawati Kencana , Hadi Winoto , Valdeza Sandy , Prasetyo Ade Chandra , Habel Rizki Hamdallah
Published: June 2024

Arena Software adalah perangkat lunak simulasi dan otomasi yang dikembangkan oleh Modeling Systems. Perangkat lunak Arena dapat digunakan untuk menganalisis sistem produksi, sistem distribusi, dan sistem antrian, seperti sistem antrian di stasiun Commuter Line (KRL). Model tersebut mensimulasikan antrian masuk di stasiun KRL untuk mengetahui pelayanan mulai dari pelanggan masuk, antri membeli tiket, antri keluar, menunggu keluar peron, dan sebagainya. Penelitian ini bertujuan untuk mengetahui berapa lama waktu yang dibutuhkan server untuk mengisi ulang saldo kartu dan jumlah orang yang mengantri di pintu gerbang bagi pengguna yang sudah memiliki saldo pada jam sibuk di stasiun Manggarai Pintu Barat. Penelitian ini menggunakan metode tinjauan literatur dan pengumpulan data lapangan dengan pengolahan perhitungan dan analisis data antrian pelanggan. Setelah perhitungan selesai, data dimodelkan menggunakan software Arena. Hasil penerapan model tersebut, pada jam sibuk pagi hari (06:00 - 08:00), jumlah penumpang yang datang untuk mengisi ulang kartu di loket sebanyak 76 orang dan jumlah penumpang dengan saldo di kartu (tidak isi ulang) sebanyak 407 orang, Sedangkan pada sore hari (16.00 - 18.00), jumlah pengunjung yang mengisi ulang kartunya di loket sebanyak 87 orang dan pelanggan yang memiliki saldo kartu sebanyak 825 orang.
Eskalasi Literasi Keuangan Dalam Pengelolaan Keuangan Keluarga Sebagai Upaya Minimalisasi Digital Fraud
Authors: Della Ayu Zonna Lia
Published: June 2024

Literasi keuangan menjadi salah satu aspek penting dalam upaya pengelolaan keuangan keluarga. Indeks literasi keuangan Indonesia mencapai 49,5% pada tahun 2022 menurut OJK (Annur, 2022). Meskipun mengalami peningkatan, pengembangan softskill mengenai pengelolaan keuangan dalam keluarga masih perlu dilakukan guna efisiensi manajemen keuangan (Sukirman et al., 2019). Selain pengelolaan keuangan keluarga, literasi keuangan juga memiliki kaitan erat dengan pencegahan cybercrime atau digital fraud yang ada di masyarakat. Kejahatan berupa sim swap, OTP fraud, dan phishing menjadi salah satu kejahatan yang marak di Q1 tahun 2023 (Kristiani, 2023). Melalui kondisi tersebut, pengabdian masyarakat ini dilakukan untuk mengedukasi ibu rumah tangga di Desa Bumiaji Kota Batu agar lebih memiliki kemampuan mengelola keuangan keluarga secara efektif terutama dalam upaya minimalisir digital fraud. Kegiatan sosialisasi dan pendampingan dilaksanakan di Balai Desa Bumiaji secara interaktif. Sehingga, peserta mampu memahami materi, melakukan diskusi dan mendapatkan jawaban atas permasalahan yang dihadapi dalam pengelolaan keluarga.
Sadakat Ve Liyakatin Anahtarı: Devşirme Sistemi
Authors: Tekin Rahmi , Şen Yağmur
Published: June 2024

Osmanlı Devleti’nde toplum iki grup halinde ele alınır. Bunlardan birincisi askerî sınıf, diğeri ise reâyâ sınıfı olarak adlandırılır. İdarî sisteme bağlı olarak bugünkü manâda hem askerlik hizmeti yapanlar, hem de memur statüsünde bulunanlar askerî sınıf içinden yetiştirilirdi. Buna göre, devletin asker, yönetici ve birçok alanda memurluk ihtiyacını karşılamak amacıyla, bazı gayrimüslim ailelerin erkek çocuklarından sağlıklı, düzgün ve zeki olanları seçilerek, sıkı bir eğitime tabi tutulurlardı. Söz konusu eğitime alınacak çocuklar, devşirme usulüyle temin edilirdi. İhtiyaç doğrultusunda uygulanan bu devşirme sistemi, Osmanlı klasik dönemde, devletin belirlemiş olduğu bazı kanun ve nizamnâme çerçevesinde yapılmıştır.
I. Murad (1362-1389) döneminden itibaren uygulanmaya başlanan bu sistem, Fatih Sultan Mehmed (1444-1446/1451-1481) döneminde kanunlaşmıştır. Osmanlı Devleti’nde yaklaşık 150 yıl (XVI. yüzyılın son çeyreğine kadar) uygulanan bu sistem, zamanla anlamını yitirmiş ve XVIII. yüzyıl ortalarından itibaren tamamen ortadan kaldırılmıştır.
Nahdlatul Ulama (NU) and the Fiqh of Civilization (Fikih Peradaban): Strategies, Contributions, and Challenges in Overcoming the Humanitarian Crisis
Authors: Taufiq Firmanda , Tsauro Ahalla
Published: June 2024

Islamic boarding schools (pesantren) as places where Islamic scientific discourse is studied and discussed have become important actors in the study of fiqh. This study has also become one of the things that is often discussed and debated in Islam because fiqh is dynamic compared to other studies. Meanwhile, Nahdlatul Ulama (NU) as one of the largest Islamic mass organizations in Indonesia also has a breakthrough in matters of fiqh, namely proposing civilizational fiqh (fikih peradaban) in response to various global problems. In this case, civilizational fiqh also seeks to find solutions to overcome humanitarian crisis problems, especially those related to conflict and its impacts. This article attempts to show the strategic patterns, contributions, and challenges of Nahdlatul Ulama (NU) in viewing and studying civilizational fiqh in the context of a humanitarian crisis. The theory used in this research is the theory of religious authority. This research is based on library research by examining various relevant literature, both in the form of books, journal articles, research reports, and other related sources needed in this research. Next, the data obtained was analyzed by interpreting the sources obtained and narrated in descriptive form. The results of this research show that Nahdlatul Ulama (NU) has made an important contribution to reforming civilizational fiqh in Indonesia. Apart from that, fiqh can answer various problems of religious practice in society, such as the humanitarian crisis in the world like Palestine-Israel conflict, Rohingya refugees, and many others conflict cases that mediated by NU.
Portrait of Equality, Justice, and Humanitarian Crisis in Scopus Database: A Bibliometric Study
Authors: Hudaa Syihaabul , Ying Luo , D'Agustino Matteo
Published: June 2024

Equality, justice, and humanitarian crises are complex issues for people worldwide. These issues have always interested researchers worldwide and have been published in the Scopus database. The purpose of writing this article is to analyze articles that have been published in the Scopus database. Researchers try to find exciting research throughout the year using keywords in research that are trending research topics. This research is included in a literature study using descriptive qualitative analysis. Researchers traced the keywords in this study: equality, justice, and humanitarian crises, then collected them in CSV files. The collected data was analyzed using bibliometric analysis using bibliophily. It was found that authors from the Americas and Europe dominate the Scopus database. In addition to the authors, the journals that published the issue were from the Americas and Europe. The topics researchers are talking about from the results of bibliometric mapping include human and humanitarian crises, war, mental health, military intervention, migration, and others.
Failure of Good Faith in Mediating Divorce Cases in Religious Court
Authors: Saifullah Muhammad , Anwar Khoirul , Murtadho Ali , Mubarok Ferry Khusnul , Kurniawan Cecep Soleh
Published: June 2024

Divorce mediation carried out outside the court (community) and within court, institutions has yet to be effective even though the government has issued a Supreme Court Regulation regarding mediation in court. The achievement of mediation success, which is still below 5%, has encouraged the Supreme Court to add an article on good faith (article 7, Supreme Court Regulation No. 1 of 2016) as a principle of mediation and the threat of sanctions for parties who do not have good faith. This study aims to reveal how the good faith clause is implemented in resolving divorce conflicts through mediation and sanctions for parties who do not act in good faith at the Pekalongan Religious Court. The data mining method was carried out through interviews with mediators, mediator judges at the Pekalongan Religious Court area, parties to the conflict, and experts in the field of mediation. Data mining was carried out through observational and documentation of domestic conflict studies. The collected data was analyzed through descriptive analysis. This paper concludes that (1) the principles of mediation have not been fully carried out in good faith in resolving divorce conflicts through mediation outside the court, so mediation fails and results in the neglect of protracted conflict issues, (2) mediation in the majority of courts lack of success due to internal and external factors, and (3) the mediator or mediator judge experiences difficulties in implementing sanctions against parties who do not have good intentions in resolving family conflicts. This research recommends that outsied of the court mediation be carried out by professional mediators who support the success of the mediation process in the justice system.
The Art of Moderation in Islamic Semantic Legal Theory: The Case of Yūsuf al-Qaraḍāwī’s Fiqh al-Aqalliyyāt
Authors: Aziz Muhammad Abdul
Published: June 2024

Abundant studies on Islamic art have been written, ranging from those based on the dimensions of universality, philosophy, and legal aspects. Yet, how it represents a sense of moderation, which can be found in Islamic semantic legal theory is something underdeveloped. The present research hence aims to reveal this aesthetic dimension examined in the context of Yūsuf al-Qaraḍāwī's jurisprudence for Muslim minorities (fiqh al-aqalliyyāt). Apart from the descriptive analysis, this qualitative research will employ a content analysis method to figure out al-Qaraḍāwī's paradigm in Islamic art, moderation, and fiqh al-aqalliyyāt inherent in his multiple works and interrelate to each other. This study concluded that the aesthetic moderation of the Islamic semantic legal theory lies in the four terms falling under the theory of meaning clarity (naẓariyyat al-wāḍiḥ al-dilālah), i.e., manifest (al-ẓāhir), explicit (al-naṣṣ), unequivocal (al-mufassar), and perspicuous (al-muḥkam). The terms produce beautiful meanings, moving gradually from particularity to universality and corresponding to characters of perfection (symmetrical) and elasticity (asymmetrical). In al-Qaraḍāwī's fiqh al-aqalliyyāt's issues like religious pluralism, greeting other religions' festivals, and democracy, the beauty crystallizes in a thesis that every Muslim must have perfect faith and, at the same time, elastic social association with people of other religions. These findings are expected not only to provide new avenues for the discourse of Muslim minorities but also of Islamic art and semantic law.
Legal Implications of Marriage During the 'Iddah Period: Analytical Study of the Opinions of Fiqh Scholars
Authors: Bariah Oyoh , Ferianto Ferianto
Published: June 2024

Divorce between a man and a woman, whether due to death, divorce, or a court decision, results in the application of the law of 'iddah (a waiting period) in Islam.  Compilation of Indonesian Islamic Law (KHI) Chapter VI Article 40 letter b concerning the Prohibition of Marriage, that it is prohibited to enter into a marriage if a woman is still in the 'iddah period with another man. This marriage prohibition applies to both men and women simultaneously.'Iddah is a stipulation of Allah's Shari'a for women who have broken up with their marital relationship to carry out the waiting not to get married at a certain time to hifdz an-nail that guarantees the honor of the child's lineage in the family so that by 'iddah the woman's womb is clean from pregnancy and the most basic goal of ‘iddah is for ta'abbudi. So, based on ta’abbbudi, the law of carrying out 'iddah is obligatory and sinful for those who break it, both men and women. So, The legal implications for those who marry during the 'iddah period, either iddah due to death or divorce for both men and women who have or have not had sexual intercourse, are that marriage is broken (faced) and must be annulled, and if they have had sexual relation, both of them' you have committed adultery and sinned, even according to Imam Malik because of sexual intercourse, it is haram for a husband who marries a woman during 'iddah to remarry that woman forever. Jumhur ulama allows both men, whether the first husband who divorced her or the second husband who marries a woman during the 'iddah period, to remarry her on condition that the woman has carried out her two periods of 'iddah perfectly, furthermore allowed to marry the man she chose.
Recent Progress of Glutathione Peroxidase 4 Inhibitors in Cancer Therapy
Authors: Liu Shangde , Wang Jian
Published: June 2024

Ferroptosis is a novel type of programmed cell death that relies on the build-up of intracellular
iron and leads to an increase in toxic lipid peroxides. Glutathione Peroxidase 4 (GPX4) is a
crucial regulator of ferroptosis that uses glutathione as a cofactor to detoxify cellular lipid peroxidation.
Targeting GPX4 in cancer could be a promising strategy to induce ferroptosis and kill drugresistant
cancers effectively. Currently, research on GPX4 inhibitors is of increasing interest in the
field of anti-tumor agents. Many reviews have summarized the regulation and ferroptosis induction
of GPX4 in human cancer and disease. However, insufficient attention has been paid to GPX4 inhibitors.
This article outlines the molecular structures and development prospects of GPX4 inhibitors
as novel anticancer agents.
Chrysin Nanoparticles Inhibit Succinate Dehydrogenase and Ubiquinone Oxidoreductases to Treat Pancreatic Cancer
Authors: Teotia Kreetika , Yadav Shikha , Aftab Alam Md. , Khan Javed , Prajapati Shatrudhan
Published: June 2024

Pancreatic adenocarcinoma is projected to become the most prevalent cancer globally until
2030. Normally, mitochondria play a crucial role in providing the energy needed for cell survival.
Targeting using natural remedies, mitochondrial complex and ubiquinone oxidoreductase holds
promise as a potential a naturally occurring flavonoid called chyrsin is being researched for its potential
to cure cancer. Due to chitosan's adaptable and versatile properties, including cationic properties,
biodegradability, high adsorption capacity, biocompatibility, ability to form films, and adhesive properties,
which contribute to its anti-cancer effects, chitosan-chrysin Nano-formulations (CCNPs) are
increasingly used in medicine to increase its bioavailability and effectiveness. Additionally, Cs (chitosan)
is considered safe and cost-effective. CCNPs show potential for the purpose of treating pancreatic
adenocarcinoma, and a number of substances are being researched as prospective therapeutic
possibilities. Researchers want to stop the cancer and investigate possible therapies for pancreatic
adenocarcinoma by blocking succinate ubiquinone oxidoreductase cell's energy production and survival
mechanisms.
Arbutin's Potential in Neuroprotection: A Promising Role in Mitigating
Neurodegenerative Diseases
Authors: Sharma Akhil , Kakkar Aryan , Khanna Malika , Devi Sushma
Published: June 2024

Naturally occurring glycosylated hydroquinone Arbutin, has drawn interest due to its
possible function in reducing the risk of neurodegenerative diseases such as Huntington's disease,
amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease. Arbutin is well-known
for its anti-inflammatory and antioxidant properties, which are essential in preventing oxidative
stress and neuroinflammation. Research has shown that arbutin might alter important physiological
pathways connected to protein misfolding, synapse function, and neuronal survival processes
linked to the development of neurodegenerative diseases. Arbutin can also penetrate the blood-
-brain barrier, which increases its therapeutic potential. Arbutin's neuroprotective properties and
promise as a therapeutic agent for neurodegenerative illnesses are summarized in this review,
which also emphasizes the need for further study into the molecular processes behind these effects.
socio-affective development of primary schoolchildren in rural areas based on the integration of educational agencies
Authors: Zamora-Pérez Kirenia , Machuca-Fernández Larissa , Rodríguez-Venereo Roxana
Published: June 2024

Cuban Primary Education has the social responsibility of contributing to the comprehensive formation of the student's personality. However, the increasing level of complexity of social and educational environments, associated with the increase in anti-values, the poor perception of risk with minors from home, among other causes, generates the need for educational practices, even when working the cognitive and affective component, give more weight to the socio-affective aspect in the training process. In this order, the proposal made favors the educational influence for the socio-affective development of the primary school child based on the integration of school - family - community in the rural context.
Review of Julie Golia, Newspaper Confessions: A History of Advice Columns in a Pre-Internet Age (2021)
Authors: Goodwyn Helena
Published: June 2024

Review of Julie Golia, Newspaper Confessions: A History of Advice Columns in a Pre-Internet Age (2021)
Identification of The Secondary Metabolite Derived from Aaptos spp. and its Antibacterial Activity
Authors: Utami Setyowati Triastuti , Paramita Nabila Syahida Prajna , Agustina Khusnul , Maulidia Faiqoh Nur , Prayoga Muhammad Bagas , Nugroho Aji , Gusnaniar Niar , Putro Eko Wahyu , Handayani Ira , Santosa Djoko , Apsari Cintya Nurul , Atikana Akhirta
Published: June 2024

Many novel bioactive compounds have been found to be most abundantly produced by sponges. Over the years, Indonesian sponges have played an important role in expanding our understanding of chemical diversity and biological activity. Among those sponges, the sponge genus Aaptos has been shown to have antimicrobial activity. Antimicrobial resistance and the spread of infections in the immunocompromised population have all contributed to an increase in the appearance and severity of these infections in recent decades. Finding an alternative antimicrobial drug from marine secondary metabolites will be beneficial. The current study looks into the profile of bioactive compounds derived from the sponge Aaptos. The sponge was collected from Raja Ampat Island, Indonesia. This sample was extracted with ethanol and an ethyl acetate-methanol solvent. Furthermore, Thin Layer Chromatography (TLC), High-performance liquid chromatography with diode-array detection (HPLC-DAD) and Principal Component Analysis (PCA) were used to map the secondary metabolite related to antimicrobial activity in both extracts. TLC profiling revealed potential alkaloid and terpenoid compounds from both ethanol extract and ethyl acetate-methanol. The HPLC-DAD and PCA results revealed that one of the ethanol crude extracts had a similar profile to Ciprofloxacin, Chloramphenicol, and Ampicillin. These antibacterial profiles open up new research avenues, with the ultimate goal of contributing to the development of new and effective antimicrobial drugs. This research also helps with the bioprospecting of marine sponges from Indonesian sea water.
Research on College English Curriculum with a Focus on Ocean Awareness
Authors: Huang Ning
Published: June 2024

This paper delves into the design of a college English curriculum centered on cultivating ocean awareness. Against the backdrop of globalization and increasing attention to marine resources, this study emphasizes the importance of integrating ocean awareness into college English teaching to enhance students’ global perspectives and cross-cultural communication skills. By meticulously incorporating ocean-related topics, innovating teaching methods and tools, constructing a scientific and reasonable evaluation system, and organizing a variety of practical activities, this research aims to comprehensively foster students’ ocean awareness. This innovative curriculum design not only provides students with a broader learning perspective but also injects new vitality into the reform of college English education, thereby effectively promoting the overall development and improvement of students’ competencies.
Exploration of the Reform of Blended Teaching in Digital Electronic Technology under the Background of Emerging Engineering Education
Authors: Duan Zhengyu
Published: June 2024

Against the backdrop of the Ministry of Education's active promotion of Emerging Engineering Education (E3), this paper proposes ideas and measures for the reform of digital electronic technology teaching from the perspective of talent cultivation to meet society's new expectations for talent development. The goal is to cultivate students' comprehensive qualities, enhance their engineering practice and innovation abilities, and promote the healthy development of teaching. Addressing current issues in digital electronic technology experimental teaching, such as outdated teaching methods, monotonous content, and incomplete and subjective evaluations, this paper advocates for a blended teaching model as the direction for reform. The aim is to effectively strengthen teachers' real-time monitoring of students' learning situations and process guidance in practice, stimulate students' enthusiasm and initiative in learning, improve classroom participation in experimental courses, and conduct teaching evaluations more scientifically and accurately.
Open Prototyping
Authors: Hemment Drew , Vidmar Matjaz , Koppel Keili , Earl Steve
Published: June 2024

Open Prototyping is a design approach and process to imagine, navigate and shape co-creation projects.
It offers a way to bridge disciplinary viewpoints and connect to communities in the real world through experiential prototypes.
It enables teams to design, structure and evaluate collaborative R&D, and address urgent challenges through participatory experiments with data and technology.
You can use the toolkit it to develop new products and services, reflect on their impact, and co-shape the future of technology and society.
DIJALEKATSKE KARAKTERISTIKE GOVORA MLADIH SA PRIZRENSKO-TIMOČKOG GOVORNOG PODRUČJA – STEPEN ISPITANOSTI
Authors: Stanković Dragana
Published: June 2024

The paper presents dialectological and teaching methodology research that explores the dialectal characteristics of the speech of young individuals in the Prizren-Timok (P-T) linguistic region. In an attempt to depict speech in its original, authentic, and unaltered form, traditional dialectology tends to exclude the speech of the youth, labelling it as "unreliable" and lacking authenticity. This judgment is rooted in the belief that many dialectal features are diminished in the speech of young individuals due to their heightened exposure to the standard language. Conversely, conventional grammar teaching is grounded in the mechanical adoption of standard language rules, actively discouraging the expression of dialectal features and deeming them irregular and undesirable. An examination of contemporary literature in dialectology and Serbian language teaching methodology reveals a growing interest among researchers in the speech patterns of young individuals from the P-T linguistic region. Dialectologists have investigated different aspects of the speech of young people, covering various linguistic levels such as prosody, phonetics, morphology, syntax,semantic and lexicon. Applying various methodologies, researchers have observed the coexistence of forms from the standard language and dialects, the fading of specific dialectal features, and the persistence of others on all linguistic levels. In teaching methodology research authors highlight the need to update teaching methods, show consideration for students' language preferences, integrate instruction with personal experiences, and, foremost, establish a link between dialectal and standard language systems. Given that the speech of young individuals reflects the emerging tendencies of a particular dialect and serves as the foundation for grammar instruction in acquiring the standard language, the description of youth speech provided by the presented research is of significant importance. This holds relevance not only for further investigations into the P-T speech but also for the more effective implementation of grammar instruction within the P-T linguistic area.
León Felipe más allá del exilio
Authors: Ruiz Dueñas Jorge
Published: June 2024

Discurso de ingreso de Jorge Ruiz Dueñas a la Academia Mexicana de la Lengua, el 8 de octubre de 2019. Da respuesta Roger Bartra.
Importancia del abordaje y tratamiento de la obesidad infantil
Authors: Delgadillo Reyes Diego Alfonso
Published: June 2024

La obesidad infantil es actualmente un problema cada vez más grave a nivel mundial. Casi 1 de cada 5 niños tiene obesidad. La problemática radica en que los niños con obesidad tienden a desarrollar otros problemas de salud graves, como enfermedad cardíaca y diabetes tipo 2, además de desarrollar ansiedad, depresión y problemas de autoestima. La obesidad infantil es un problema de salud pública complejo en México, ya que están relacionados diferentes factores como el genético, la alimentación, el ejercicio físico y los patrones de alimentación, muchos de los cuales se aprenden o heredan (como los genéticos) y que llegan a persistir en la edad adulta, al igual que las enfermedades que subyacen del padecimiento de la obesidad, sin dejar de lado otros aspectos como los sociales, actuales que se viven en el país, impactan de forma indirecta en la prevalencia del sobrepeso y la obesidad infantil. Por lo que en este trabajo se realiza un abordaje de estos factores y la importancia de darle solución a esta problemática para evitar daños y problemáticas mayores en los futuros adultos.
Vinculaciones entre la depresión y la obesidad
Authors: Vázquez Vela Alejandra Ivonne , Delgado Jacobo Dolores Patricia
Published: June 2024

La obesidad y la depresión son dos importantes problemas de salud pública en México que afectan a una parte sustancial de la población. La relación entre obesidad y depresión es compleja y bidireccional. Los estudios han indicado que la obesidad puede aumentar el riesgo de desarrollar depresión, debido potencialmente a factores biológicos, psicológicos y sociales. Además, el estigma y la discriminación asociados a la obesidad pueden contribuir al desarrollo o la exacerbación de los síntomas depresivos. La tendencia del sobrepeso y la obesidad es actualmente conocido como un proceso multifactorial, sin embargo, es bien sabido que la regulación emocional influye en la toma de decisiones; al ser relacionado con la depresión, que representa el cambio en el patrón alimenticio, siendo la ingesta de estos alimentos con una motivación de afecto negativo, teniendo entonces está relación entre la emoción negativa que representa la depresión y la alimentación emocional. Con el objetivo de conocer la asociación entre la obesidad y la depresión, en este trabajo se realizó una revisión teórica de artículos científicos que explican la relación de estas variables.
Clasificación según Kennedy de arcos edéntulos en pacientes atendidos en una clínica universitaria en Cartagena
Authors: Tirado Amador Lesbia Rosa , Herrera Calderón Anggie , Vargas Quiroga Edgar , Padilla Henao Luis Felipe , Pérez Gómez Yuleisis , Taborda Meléndez Aida
Published: June 2024

Introducción: el edentulismo es un problema de salud pública causado por la acumulación de patologías orales, afectando a la población de adultos mayores y a población joven en condiciones sociales desfavorecidas, provocando efectos negativos en la apariencia facial, nutrición, capacidad de comer, hablar y socializar. El edentulismo parcial implica la ausencia de uno o varios dientes, y se clasifica con base en el método de Kennedy que es el más aceptado entre la comunidad odontológica. Objetivo: caracterizar los arcos dentales parcialmente edéntulos en pacientes atendidos en una clínica odontológica universitaria de Cartagena en el periodo de 2015 a 2018. Material y métodos: se realizó un estudio descriptivo de corte transversal empleando historias clínicas. La muestra se obtuvo mediante criterios de selección. Se consideró la normativa vigente en Colombia y la declaración de Helsinki, y se realizó solicitud de aval de ética y permiso para acceder al archivo clínico. Para la recolección de la información se diseñó y validó una ficha de registro, empleada por cuatro estudiantes previamente capacitados. El análisis descriptivo y la prueba de chi-cuadrada se desarrolló empleando el software spss ibm®, versión 11. Resultados: se revisaron en total 130 historias, de las que 111 cumplieron los criterios de selección. Predominó el sexo femenino con casi el 75% de las historias incluidas. El motivo de consulta más frecuente fue por estética acercándose al 80%. 47% del edentulismo se presentó en la mandíbula (IC95%=37,31-56,55), seguido del edentulismo bimaxilar. Se halló una relación estadísticamente significativa con la edad, para el grupo de 46 a 63 años con mandíbula clase I según la clasificación de Kennedy. Conclusión: el tipo de arco dental predominante parcialmente edéntulo fue Clase III en el maxilar y Clase I en la mandíbula, según la clasificación de Kennedy. No se presentó asociación entre el sexo con el tipo de edentulismo parcial y la clasificación de los arcos dentales.
Pedagogías críticas y transmodernidad Dusseliana. Una revisión bibliográfica en busca de encuentros
Authors: Erazo Cruz Cicerón , López Noreña Germán
Published: June 2024

El artículo tiene como objetivo identificar y mostrar las principales investigaciones, en América Latina y Colombia, en torno a la conexión transmodernidad y pedagogías críticas. Esta revisión bibliográfica busca cimentar la formulación de una pedagogía crítica latinoamericana a partir de los supuestos pedagógicos de Enrique Dussel. Para cumplir dicho propósito, metodológicamente (enfoque cualitativo), se realizó la búsqueda y examen de textos en diversas bases de datos científicas; después, se ejecutó un Análisis Documental de Contenido a 42 estudios. Así, se encontraron tres tendencias o perspectivas teóricas para analizar el vínculo: primero, lo pedagógico transmoderno en lo comunitario y los movimientos sociales. Segundo, la relación pedagogía/transmodernidad en los escenarios educativos institucionales. Tercero, la unión pedagogía y transmodernidad desde la perspectiva de la Pedagógica latinoamericana. Finalmente, se pudo concluir que hay varios abordajes sobre el nexo transmodernidad y pedagogía en Enrique Dussel; no obstante, dicha ligazón se establece en alusión a una práctica pedagógica o social concreta (situada) o queda anclada en una visión pre-transmoderna (anterior a 1992). En ningún caso, se evidencia un estudio sistemático de la obra del autor, posterior a 1992, en busca del mencionado vínculo, lo que implica que esa es una tarea por realizarse.
Analisis Kualitas Air pada Kolam Pendederan Benih Ikan Karper (Cyprinus carpio L.)
Authors: Deo Sandika  , Dewa Gede Semara Edi  , I Made Kawan
Published: June 2024

Penelitian ini merupakan studi kasus yang bertujuan untuk mengetahui kondisi kualitas air pada kolam pembenihan Ikan Mas(Cyprinus carpio L.). Penelitian ini dilaksanakan 21 hari pada bulan Juni 2023 di UPTD. Produksi Perikanan BudidayaProvinsi Bali. Desain penelitian ini dibagi menjadi 4 tahap, dimulai dari persiapan, pelaksanaan, analisis data dankesimpulan. Pengamatan kualitas air meliputi beberapa parameter fisik, kimia dan biologi. VariabelYang diamati adalah suhu, kecerahan, pH, amonia dan kelimpahan plankton. Tujuan dari penelitian ini adalah untuk mengetahuikondisi kualitas air di lokasi penelitian, mengetahui fluktuasi harian kualitas air dan juga menentukanhubungan antara variabel kualitas air. Berdasarkan hasil pengamatan diketahui suhu rata-rataNilainya mencapai 27,7Â°C, kecerahan rata-rata 36,7 cm, pH rata-rata 7,2, amonia rata-rata 0,15 danrata-rata kelimpahan plankton mencapai 1.119 sel/L. Diketahui terjadi fluktuasi air yang cukup signifikanvariabel kualitas baik sehari-hari maupun selama periode penelitian, dan diketahui juga ada
Vascular cognitive impairment after ischemic stroke
Authors: Dewi Made Wulan Utami , Laksmidewi A.A.A Putri
Published: June 2024

Background Post-stroke cognitive impairment is the leading cause of post-stroke morbidity and mortality worldwide. This impairment is often associated with ischemic stroke and intracerebral hemorrhage. Cognitive impairment could affect attention, memory, language, orientation, and executive and social functioning domains.
Case We reported a male patient, 45 years old, Javanese, who came with confusion and memory impairment. When asked a question, the patient tends to think and answer slowly with a wrong response. He also felt weakness in the right half of the body, slurred speech, pursed lips, and had been diagnosed with ischemic stroke. One week after he was sent home, patient still had difficulty arranging words to form a sentence and could not work. Cognitive function screening showed impairment in attention and memory domain with a MOCA-INA score of 19/30. Patients received antihypertensive therapy, dual antiplatelet, statin, and cognitive stimulation. His condition improved with this treatment.
Conclusion Early identification of cognitive impairment could reduce morbidity in stroke patients.
Diphtheritic Polyneuropathy: A Rare Complication that Needs to be Acknowledged
Authors: Jaya Fandy Ong , Lee Priscilla Love , Ritarwan Kiking
Published: June 2024

Globally, diphtheria still poses a burden on public health, predominantly in developing countries. Poor vaccine coverage and boosters are the main factors in the diphtheria outbreak that should have been obliterated as the vaccine was invented a century ago. Health services are particularly burdened by diphtheria because it can lead to both short-term complications like acute airway obstruction and long-term complications like myocardial toxicity and diphtheritic polyneuropathy. Data about diphtheritic polyneuropathy is scarce, and physicians may not be aware of this condition. Herein we present the pathophysiology, clinical manifestation, diagnosis, and treatment of diphtheritic polyneuropathy.