bluuebunny/crossref_metadata_2025 huggingface dataset:
Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries
Authors: Fang Qing , Jing Guoqing , Zhang Ying , Wang Hongyu , Luo Huan , Xia Yun , Jin Qiyan , Liu Yuping , Zuo Jing , Yang Cheng , Zhang Xiaodong , Liu Shi , Wu Xiaojing , Song Xuemin
Published: December 2023

Mounting attention has been focused on defects of the autophagy-lysosomal pathway in sepsis, however, the precise mechanisms governing the autophagy-lysosomal process in sepsis are poorly known. We have previously reported that Erbin deficiency aggravated the inflammatory response and organ injuries caused by sepsis. In the present study, we found that Erbin knockout impaired the autophagy process in both muramyl dipeptide (MDP)-induced bone marrow-derived macrophages (BMDMs) and sepsis mouse liver and lung, as detected by the accumulation of LC3-II and SQSTM1/p62, and autophagosomes. Pretreatment with autophagy inhibitor chloroquine (CQ) further aggravated inflammatory response and organ injuries in vivo and in vitro sepsis model. We also observed that the impaired lysosomal function mediated autophagic blockade, as detected by the decreased expression of ATP6V, cathepsin B (CTSB) and LAMP2 protein. Immunoprecipitation revealed that the C-terminal of Erbin (aa 391–964) interacts with the N-terminal of transcription factor EB (TFEB) (aa 1–247), and affects the stability of TFEB-14-3-3 and TFEB-PPP3CB complexes and the phosphorylation status of TFEB, thereby promote the nucleus translocation of TFEB and the TFEB target genes transcription. Thus, our study suggested that Erbin alleviated sepsis-induced inflammatory responses and organ injuries by rescuing dysfunction of the autophagy-lysosomal pathway through TFEB-14-3-3 and TFEB-PPP3CB pathway.
Towards telehealth delivery in pediatric rheumatology practice
Authors: Khubchandani Raju , Avčin Tadej , Ravelli Angelo
Published: December 2023

Introduction

Much has been written and spoken about telemedicine since about two decades including an article in this journal at the start of the pandemic. It took a global catastrophe to enforce its usage across the world in various medical specialties. Telemedicine however remains unstructured, unregulated and lacks uniformity.

Discussion

This article highlights the practical learnings and opinions of the authors who provided over two thousand video consults and asynchronous telemedicine services through the entire pandemic. It includes lessons learnt from emerging economies where pediatric rheumatologists are scarce. Pediatric rheumatology, which relies heavily on history, musculoskeletal and skin examination is aptly suited to exploit telemedicine in its synchronous and asynchronous forms. Pediatric tele rheumatology could temporarily address the shortage and uneven distribution of specialists in vast parts of the globe, besides serving as a method of triage and shared care with the primary physician. Reduction of direct and indirect costs and family/primary physician education are additional benefits. There also exist challenges for all stakeholders and it is important to address the latter.

Conclusion

The learnings of the pandemic suggest a vital role for telemedicine in the practice of pediatric rheumatology. This is a fertile area for research and consensus building by international and national pediatric societies and issue position statements like some adult bodies already have. The authors speculate a hybrid system of care in the not-so-distant future.
East meets west: using ethnobotany in ethnic urban markets of Barcelona metropolitan area (Catalonia) as a tool for biocultural exchange
Authors: D’Ambrosio Ugo , Pozo Cristina , Vallès Joan , Gras Airy
Published: December 2023

Background

Ethnobotanical studies in metropolitan areas and urban ethnic markets have grown considerably in recent years as large cities have demonstrated to be significantly rich in biocultural diversity and in driving its evolution, as human populations migrate from one region to another. Urban spaces also represent important places of rich multicultural and multilingual interaction and exchange, where ethnobotany can act as a bridge between research and action. The purpose of this study is to present a case study on how to use ethnobotany in multicultural urban settings by studying people-plant interactions and the larger implications and applications to promote biocultural learning in these areas.

Methods

We inventoried the botanical composition of fresh and dry products sold in most food stores owned by Chinese immigrants in Fondo, a neighbourhood of Barcelona’s metropolitan area, in Santa Coloma de Gramenet municipality (Barcelonès county, Catalonia, Iberian Peninsula), pharmacologically validating the obtained list with the Chinese Pharmacopoeia. We also participated in multiple dissemination activities and materials (non-academic and academic), along with exchanges with the broader community in relation to this research.

Results

In total, 103 plants were identified at the species level, pertaining to 88 genera and 46 botanical families. Including the infraspecific level, a total of 113 plant taxa were inventoried. One algal and six fungal species were also recorded, but not included in the analyses. Brassicaceae (12.4%) and Fabaceae (10.6%) were the most predominant families inventoried, followed by Cucurbitaceae (7.1%) and Poaceae (7.1%). Over three-quarters of all the taxa have an Asian origin (76.11%), indicating a high conservation of the use of Asian taxa. Over one-third (36.89%) of the plant parts pertain to species contained in the Chinese Pharmacopoeia, showing the relevance of medicinal plants in local stores and the preponderance of Eastern Asian food-medicine continuums. To promote ethnobotanical education programmes, over 50 dissemination activities and educational materials were produced from this study and shared with the local urban community in different fora.

Conclusions

Further research in these and similar settings can provide significant ethnographic information to better understand anthropological processes and phenomena underlying migration and transculturation that can be used in an umbrella of applications, from adequate nomenclature and labelling of foreign products in local languages to multicultural integration and social cohesion programmes along with educational activities on biocultural topics.
Direct letters to relatives at risk of hereditary cancer—study protocol for a multi-center randomized controlled trial of healthcare-assisted versus family-mediated risk disclosure at Swedish cancer genetics clinics (DIRECT-study)
Authors: Hawranek Carolina , Ehrencrona Hans , Öfverholm Anna , Hellquist Barbro Numan , Rosén Anna
Published: December 2023

Background

The results of germline genetic testing for hereditary cancer are of importance not only to the patients under investigation but also to their genetic at-risk relatives. Standard care is to encourage the proband (first family member under investigation) to pass on this risk information to the relatives. Previous research suggests that with family-mediated disclosure, only about a third of at-risk relatives contact health care to receive genetic counselling. In some studies, complementing family-mediated risk disclosure with healthcare-assisted risk disclosure almost doubles the uptake of genetic counselling in at-risk relatives. In this study, we evaluate healthcare-assisted direct letters to relatives at risk of hereditary cancer syndromes in a randomized controlled trial.

Methods

Probands are recruited from Swedish outpatient cancer genetics clinics to this two-arm randomized controlled trial. The study recruits probands with either a pathogenic variant in a cancer susceptibility gene (BRCA1, BRCA2, PALB2, MLH1, MSH2, MSH6, PMS2) or probands with familial breast and colorectal cancer based on clinical and pedigree criteria. In both arms, probands receive standard care, i.e., are encouraged and supported to pass on information to relatives. In the intervention arm, the proband is also offered to have direct letters sent to the at-risk relatives. The primary outcome measure is the proportion of at-risk relatives contacting a Swedish cancer genetics clinic within 12 months of the proband receiving the test results.

Discussion

This paper describes the protocol of a randomized controlled clinical trial evaluating a healthcare-assisted approach to risk disclosure by offering the probands to send direct letters to their at-risk relatives. The results of this study should be informative in the future development of risk disclosure practices in cancer genetics clinics.

Trial registration

ClinicalTrials.gov. Identifier NCT04197856 (pre-trial registration on December 13, 2019).

Also registered at the website “RCC Cancerstudier i Sverige” as study #86719.
Sclerosing epithelioid fibrosarcoma associated with WRN gene variant presenting as chronic dyspnea and pathologic cervical fracture: a case report and review of the literature
Authors: Phan Alexander T. , Ghantarchyan Henrik , Khosravi Chayanne , Maknouni Bahareh , Bhagat Ankur , Chen Jeff , Ibrahim Ahmad , Hasan Mufadda
Published: December 2023

Background

Sclerosing epithelioid fibrosarcoma is an aggressive sarcoma subtype with poor prognosis and limited response to conventional chemotherapy regimens. Diagnosis can be difficult owing to its variable presentation, and cases of sclerosing epithelioid fibrosarcoma are rare. Sclerosing epithelioid fibrosarcoma typically affects middle-aged individuals, with studies inconsistently citing gender predominance. Sclerosing epithelioid fibrosarcoma typically arises from the bones and soft tissues and often has local recurrence after resection and late metastases. Immunohistochemical staining typically is positive for mucin-4. Werner syndrome is due to an autosomal recessive mutation in the WRN gene and predisposes patients to malignancy.

Case presentation

A 37-year-old Caucasian female presented to the emergency department with 4 months of dyspnea and back pain. She had been treated for pneumonia but had persistent symptoms. A chest, abdomen, and pelvis computed tomography showed near-complete right upper lobe collapse and consolidation, mediastinal lymphadenopathy, lytic spinal lesions, and a single 15-mm hypodense liver nodule. The patient underwent a transthoracic right upper lobe biopsy, bronchoscopy, endobronchial ultrasound with transbronchial lymph node sampling, and bronchoalveolar lavage of the right upper lobe. The bronchoalveolar lavage cytology was positive for malignant cells compatible with poorly differentiated non-small cell carcinoma; however, the cell block materials were insufficient to run immunostains for further investigation of the bronchoalveolar lavage results. Consequently, the patient also underwent a liver biopsy of the liver nodule, which later confirmed a diagnosis of sclerosing epithelioid fibrosarcoma. Next-generation sequencing revealed a variant of unknown significance in the WRN gene. She was subsequently started on doxorubicin.

Conclusion

Sclerosing epithelioid fibrosarcoma is a very rare entity, only cited approximately 100 times in literature to date. Physicians should be aware of this disease entity and consider it in their differential diagnosis. Though pulmonary involvement has been described in the context of sclerosing epithelioid fibrosarcoma, this malignancy may affect many organ systems, warranting extensive investigation. Through our diagnostic workup, we suggest a possible link between sclerosing epithelioid fibrosarcoma and the WRN gene. Further study is needed to advance our understanding of sclerosing epithelioid fibrosarcoma and its clinical associations as it is an exceedingly rare diagnosis.
Primary malignant melanoma, an atypical presentation in the cervical spine: a case report
Authors: Kamabu Larrey Kasereka , Kataka Louange Maha , Vivalya Bives Mutume Nzanzu , Sikakulya Franck Katembo , Lekuya Hervé Monka , Galukande Moses
Published: December 2023

Background

Few studies have documented the occurrence of melanoma in the cervical spine. Of all malignant melanoma cases, 1% are primary melanoma of the central nervous system, which makes it extremely uncommon and nonspecific. We aim to report a case of the uncommon presentation of primary melanoma in the cervical spine.

Case presentation

The patient was a 59-year-old Muganda male who presented with a 2-year history of anterior neck swelling as well as severe pain and a tingling sensation in the left shoulder and arm, which worsened in the recent 6 months. He developed weakness and paresthesia in the upper left arm and progressive gait disturbance of the left leg. A physical examination revealed masses in the left cervical and right submandibular region. Additionally, the upper and lower left extremities revealed hemiparesis and hemihypoesthesia. A magnetic resonance imaging scan showed a hyperintense lesion on TIWI and another hypointense lesion on T2WI, originating from the cervical spine and involving the vertebral bodies and paravertebral soft tissues. The patient underwent surgery, a black tumor was extracted, and histology revealed the tumor to be malignant melanoma. The patient died within 1 month after the diagnosis and surgery.

Conclusion

This case is presented to highlight the significance and challenges associated with making a pre- and postoperative diagnosis of primary cervical melanoma with atypical radiological characteristics. Patients with extradural lesions that show hyperintensity on T1-weighted images and hypointensity on T2-weighted images should have spinal melanoma examined as a possible differential diagnosis.
T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma
Authors: Qu Jiangming , Pan Boju , Su Tong , Chen Yu , Zhang Tao , Chen Xingming , Zhu Xiaoli , Xu Zhentan , Wang Tianjiao , Zhu Jinxia , Zhang Zhuhua , Feng Feng , Jin Zhengyu
Published: December 2023

Background

This study seeks to assess the utility of T1 and T2 mapping in distinguishing metastatic lymph nodes from reactive lymphadenopathy in patients with head and neck squamous cell carcinoma (HNSCC), using diffusion-weighted imaging (DWI) as a comparison.

Methods

Between July 2017 and November 2019, 46 HNSCC patients underwent neck MRI inclusive of T1 and T2 mapping and DWI. Quantitative measurements derived from preoperative T1 and T2 mapping and DWI of metastatic and non-metastatic lymph nodes were compared using independent samples t-test or Mann–Whitney U test. Receiver operating characteristic curves and the DeLong test were employed to determine the most effective diagnostic methodology.

Results

We examined a total of 122 lymph nodes, 45 (36.9%) of which were metastatic proven by pathology. Mean T2 values for metastatic lymph nodes were significantly lower than those for benign lymph nodes (p < 0.001). Conversely, metastatic lymph nodes exhibited significantly higher apparent diffusion coefficient (ADC) and standard deviation of T1 values (T1SD) (p < 0.001). T2 generated a significantly higher area under the curve (AUC) of 0.890 (0.826–0.954) compared to T1SD (0.711 [0.613–0.809]) and ADC (0.660 [0.562–0.758]) (p = 0.007 and p < 0.001). Combining T2, T1SD, ADC, and lymph node size achieved an AUC of 0.929 (0.875–0.983), which did not significantly enhance diagnostic performance over using T2 alone (p = 0.089).

Conclusions

The application of T1 and T2 mapping is feasible in differentiating metastatic from non-metastatic lymph nodes in HNSCC and can improve diagnostic efficacy compared to DWI.
Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study
Authors: Sun Kai , Eudy Amanda M. , Harris Nathaniel , Pisetsky David S. , Criscione-Schreiber Lisa G. , Sadun Rebecca E. , Doss Jayanth , Clowse Megan E. B. , Rogers Jennifer L.
Published: December 2023

Objective

To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE activity, we developed the Type 1 and 2 SLE model. We examined PROMIS-29 scores, a composite patient-reported outcome (PRO) measure, through the lens of the model.

Methods

Patients completed PROMIS-29 and the polysymptomatic distress scale (PSD). Rheumatologists completed the SLE disease activity index (SLEDAI), and physician’s global assessments (PGAs) for Type 1 and 2 SLE. We defined Type 1 SLE using SLEDAI, Type 1 PGA, and active nephritis, and Type 2 SLE using PSD and Type 2 PGA. We compared PROMIS-29 T-scores among Type 1 and 2 SLE groups and explored whether PROMIS-29 can predict Type 1 and 2 SLE activity.

Results

Compared to the general population, patients with isolated Type 1 SLE reported greater pain and physical dysfunction but less depression and improved social functions; patients with high Type 2 SLE (irrespective of Type 1 activity) reported high levels of pain, fatigue, and social and physical limitations. Patients with minimal Type 1 and 2 SLE had less depression and greater physical functioning with other domains similar to national norms. PROMIS-29 predicted Type 2 but not Type 1 SLE activity.

Conclusion

PROMIS-29 similarities in patients with high Type 2 SLE, with and without active Type 1 SLE, demonstrate the challenges of using PROs to assess SLE inflammation. In conjunction with the Type 1 and 2 SLE model, however, PROMIS-29 identified distinct symptom patterns, suggesting that the model may help clinicians interpret PROs.
Endograft position and endoleak detection after endovascular abdominal aortic repair with low-field tiltable MRI: a feasibility study
Authors: van Zandwijk Jordy K. , Schuurmann Richte C. L. , Haken Bennie ten , Stassen Chrit M. , Geelkerken Robert H. , de Vries Jean-Paul P. M. , Simonis Frank F. J.
Published: December 2023

Background

Abdominal aortic endoleaks after endovascular aneurysm repair might be position-dependent, therefore undetectable using supine imaging. We aimed to determine the feasibility and benefit of using a low-field tiltable magnetic resonance imaging (MRI) scanner allowing to study patients who can be imaged in both supine and upright positions of endoleaks.

Methods

Ten EVAR patients suspected of endoleak based on ultrasound examination were prospectively included. MRI in upright and supine positions was compared with routine supine computed tomography angiography (CTA). Analysis was performed through (1) subjective image quality assessment by three observers, (2) landmark registration between MRI and CTA scans, (3) Euclidean distances between renal and endograft landmarks, and (4) evaluation of endoleak detection on MRI by a consensus panel. Statistical analysis was performed by one-way repeated measures analysis of variance.

Results

The image quality of upright/supine MRI was inferior compared to CTA. Median differences in both renal and endograft landmarks were approximately 6–7 mm between upright and supine MRI and 5–6 mm between supine MRI and CTA. In the proximal sealing zone of the endograft, no differences were found among all three scan types (p = 0.264). Endoleak detection showed agreement between MRI and CTA in 50% of the cases, with potential added value in only one patient.

Conclusions

The benefit of low-field upright MRI for endoleak detection was limited. While MRI assessment was non-inferior to standard CTA in detecting endoleaks in selected cases, improved hardware and sequences are needed to explore the potential of upright MRI in patients with endoleaks.

Relevance statement

Upright low-field MRI has limited clinical value in detecting position-dependent endoleaks; improvements are required to fulfil its potential as a complementary modality in this clinical setting.

Key points

• Upright MRI shows potential for imaging endoleaks in aortic aneurysm patients in different positions.

• The image quality of upright MRI is inferior to current techniques.

• Upright MRI complements CTA, but lacks accurate deformation measurements for clinical use.

• Advancements in hardware and imaging sequences are needed to fully utilise upright MRI capabilities.

Graphical Abstract
Outcome of endovascular stroke therapy in a large mandatory stroke-registry
Authors: Hyrenbach Sonja , Rode Susanne , Schabet Martin , Daffertshofer Michael , Schoser Karin , Neumaier Stephan , Ringleb Peter A.
Published: December 2023

Background

Endovascular stroke treatment (EST) has become the standard treatment for patients with stroke due to large vessel occlusion, especially in earlier time windows. Only few data from population-based registries on effectiveness of EST have been published.

Methods

Baden–Wuerttemberg is the third largest state in Germany in terms of area and population and has a structured stroke concept since 1998 which includes mandatory collection of quality assurance data. In 2018 and 2019, 3820 of 39,168 ischemic stroke patients (9.8%) were treated by EST (age median 78 y, NIHSS median 14). We analyzed the clinical outcome of these patients determined with the modified Rankin Scale (mRS) at discharge from the hospital or with the initiation of palliative therapy using logistic regression analysis with adjustment for the mRS at admission, additive IVT, age, and NIHSS.

Results

The probability of an excellent clinical outcome (mRS 0 or 1 at discharge) and for a good clinical outcome (mRS 0–2) were significantly higher in EST-patients (odds-ratio (OR) 1.27; 95% confidence interval (95% CI) 1.13–1.43, and OR of 1.15 (95% CI 1.04–1.28). Also, the regression model showed an advantage for EST-patients with less frequent ‘decision for palliative care’ (OR 0.87; 95% CI 0.78–0.98). Sensitivity analysis adjusting for intracranial vessel occlusion as further factor showed similar results.

Conclusion

Our data suggest that EST can be of benefit also for an area-wide unselected stroke population, in a large German federal state with sometimes long distance to the next thrombectomy center.
Evaluation of the expression of the long non-coding RNAs, LOWEG and MINCR, and their clinical significance in human gastric cancer
Authors: Ghasemzadeh Tooraj , Rajabi Ali , MalekAbbaslou Elaheh , Najari Parisa , Akbarzadeh Sama , Tayefeh-Gholami Samaneh , Teimourian Shahram , Hosseinpourfeizi MohammadAli , Safaralizadeh Reza
Published: December 2023

Background

Gastric cancer (GC) is currently the fifth most common malignancy. Accumulating evidence has recently revealed that maladjustments of diverse long non-coding RNAs may play key roles in multiple genetic and epigenetic phenomena in GC. Long non-coding RNAs (lncRNAs), which are transcriptional products with more than 200 nucleotides, are a subset of non-coding RNAs. LncRNA LOWEG and lncRNA MINCR, as novel lncRNAs, may have roles in GC progression.

Objective

This study aimed to examine the clinical and diagnostic significance of lncRNA LOWEG and lncRNA MINCR in GC.

Methods

The qRT-PCR technique measured lncRNA LOWEG and lncRNA MINCR expression in GC tissues and matched adjacent marginal tissues. The association between clinicopathological parameters and the expression level of lncRNAs was evaluated. Furthermore, The ROC curve was plotted to assess the diagnostic power of lncRNA LOWEG and lncRNA MINCR as candidate biomarkers in gastric cancer patients.

Results

We found that lncRNA LOWEG expression was downregulated in cancerous tissues compared to the adjacent marginal tissues (P-value < 0.0001). LncRNA MINCR expression was upregulated in cancerous tissues compared to adjacent marginal tissues (P-value < 0.0001). Downregulation of lncRNA LOWER and upregulation of lncRNA MINCR did not significantly correlate with clinicopathological parameters. ROC curve analysis showed that lncRNA LOWEG and lncRNA MINCR could be proposed as reliable diagnostic biomarkers in GC.

Conclusion

The expression of the lncRNA LOWEG was reduced in tumoral tissues compared to the adjacent marginal tissues, and the expression of lncRNA MINCR increased in tumoral tissues. So, as a result, lncRNAs LOWEG and MINCR could be considered diagnostic biomarkers for GC.
Permanent vs Transient Congenital Hypothyroidism in Chinese Children: Physical Growth and Predictive Nomogram
Authors: Ding Xuejing , Liu Zhiwei , Zhang Bin , Yang Yuqi , Wang Ying , Yu Bin , Long Wei
Published: December 2023

Context

Few reliable markers are available to distinguish transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH). Additionally, the differences in growth between TCH and PCH remain unclear.

Objective

To investigate the growth of children with TCH and PCH and develop a nomogram for early differentiation of these forms.

Methods

This retrospective study included children with TCH or PCH. The predictive efficacy of the prognostic predictors was analyzed using receiver operating characteristic analysis. Multivariate prediction models were developed. Measurements of growth were compared between groups.

Results

Patients with TCH had lower initial thyroid-stimulating hormone (TSH) than those with PCH at newborn screening (NBS). The supplementary dose of levothyroxine (L-T4) gradually decreased with age in TCH but not in PCH. The area under the curve (AUC) values of the initial TSH, L-T4 dose at 1 year of age, and L-T4 dose at 2 years of age for distinguishing TCH from PCH were 0.698, 0.71, and 0.879, respectively. The predictive efficacy of the multivariate models at 1 and 2 years of age improved, with AUC values of 0.752 and 0.922, respectively. A nomogram was built based on the multivariate model at 1 year of age. The growth did not differ between children with TCH and those with PCH. However, at 1 year of age, girls with CH exhibited higher z-scores in terms of height and weight than boys with CH.

Conclusion

TSH at NBS and L-T4 doses during treatment can be used to distinguish between PCH and TCH early in life, and the predictive efficacy can be improved using multivariable models with a visualized nomogram. At 3 years of age, patients with TCH and PCH showed similar growth.
Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes
Authors: Rashid Mamoon , Al Qarni Ali , Al Mahri Saeed , Mohammad Sameer , Khan Altaf , Abdullah Mashan L , Lehe Cynthia , Al Amoudi Reem , Aldibasi Omar , Bouchama Abderrezak
Published: December 2023

Context

Bariatric surgery has been shown to be effective in inducing complete remission of type 2 diabetes in adults with obesity. However, its efficacy in achieving complete diabetes remission remains variable and difficult to predict before surgery.

Objective

We aimed to characterize bariatric surgery-induced transcriptome changes associated with diabetes remission and the predictive role of the baseline transcriptome.

Methods

We performed a whole-genome microarray in peripheral mononuclear cells at baseline (before surgery) and 2 and 12 months after bariatric surgery in a prospective cohort of 26 adults with obesity and type 2 diabetes. We applied machine learning to the baseline transcriptome to identify genes that predict metabolic outcomes. We validated the microarray expression profile using a real-time polymerase chain reaction.

Results

Sixteen patients entered diabetes remission at 12 months and 10 did not. The gene-expression analysis showed similarities and differences between responders and nonresponders. The difference included the expression of critical genes (SKT4, SIRT1, and TNF superfamily), metabolic and signaling pathways (Hippo, Sirtuin, ARE-mediated messenger RNA degradation, MSP-RON, and Huntington), and predicted biological functions (β-cell growth and proliferation, insulin and glucose metabolism, energy balance, inflammation, and neurodegeneration). Modeling the baseline transcriptome identified 10 genes that could hypothetically predict the metabolic outcome before bariatric surgery.

Conclusion

The changes in the transcriptome after bariatric surgery distinguish patients in whom diabetes enters complete remission from those who do not. The baseline transcriptome can contribute to the prediction of bariatric surgery-induced diabetes remission preoperatively.
On the Anatomy of the Border of the Posterior Elastic Lamina of the Cornea, in relation to the Fibrous Tissue of the Ligamentum Iridis Pectinatum
Authors: Macdonald John Denis
Published: December 2023

On dissecting the human eye with the view of demonstrating the generally admitted metamorphosis of the whole border of the posterior elastic lamina of the cornea into the fibrous tissue from which the little tendons of the liga mentum iridis pectinatum arise, I was surprised to find that no such transformation was anywhere to be detected. The two structures, though, indeed, associated in a very intimate and peculiar manner, were nevertheless, perfectly distinct and not to be confounded with one another. This discovery led me to examine the eye of the sheep more minutely in reference to the point in question, as the pillars of the iris in that animal are very distinctly marked, being much less crowded than they are even in the ox. The result of the investigation may be simply stated as follows :
A Differential Warm Stage
Authors: Golding-Bird C. H.
Published: December 2023

The following is the description of a warm stage that appears to possess certain advantages over the simple copper one often employed, and to possess certain of those which belong to the more complicated arrangements where the heat is maintained by a constant stream of hot water.
Medical Microscopical Society: 17th December, 1875
Authors: Power H.
Published: December 2023

Dr. Pritchard exhibited’ in action the new freezing machine for cutting microscopicic sections, which has already been described in the ‘Lancet’ for December 11th, 1875.
Comparison Results of Three-Port Robot-Assisted and Uniportal Video-Assisted Lobectomy for Functional Recovery Index in the Treatment of Early Stage Non-small Cell Lung Cancer: A Propensity Score-Matched Analysis
Authors: Diao Haixiao , Xu Lin , Li Xiao , Wang Yancheng , Peng Zhongmin
Published: December 2023

Background

Minimally invasive lobectomy is the standard treatment for early stage non-small cell lung cancer (NSCLC). The aim of this study is to investigate postoperative recovery in a prospective trial of discharged patients with early stage non-small cell lung cancer undergoing robot-assisted thoracic surgery (RATS) versus uniportal video-assisted thoracic surgery (UVATS).

Patients and Methods

This is a prospective and observational study. From 9 September 2022 to 1 July 2023, 178 patients diagnosed with NSCLC admitted to the Department of Thoracic Surgery of Shandong Provincial Hospital signed informed consent and underwent lobectomy by RATS and UVATS. The functional recovery index included MD Anderson Symptom Inventory, Christensen Fatigue Scale, EORTC QLQ-C30, and Leicester Cough Questionnaire.

Results

After propensity score-matched analysis, each group included 42 cases. For the baseline characteristics of patients, operation time (p = 0.01) and length of stay (p = 0.04) were shorter in the RATS group. The number of lymph nodes resected in the RATS group was much more than in the UVATS group. According to our investigation, appetite loss, nausea, diarrhea, and cough severity after RATS were better than after UVATS. After the first week, pain severity degree of the RATS group was higher than UVATS, while there was no difference during the second and third week. The physical score of the RATS group was higher than the UVATS group (p = 0.04), according to the Leicester Cough Questionnaire.

Conclusion

RATS was associated with severe short-term postoperative pain but less postoperative complications.
DEVELOPMENT UNIFIED APPROACH TO AUTOMATION DOCUMENT TEMPLATE VERIFICATION PROCESS CREATED IN FASTREPORT
Authors: Rabovskaya Maria Ya. , Zagrebin Pavel E.
Published: December 2023

The article discusses the business processes automation for creating, modifying and checking templates for printing payment documents in the «FastReport» program using the example of organizations engaged in printing activities. The purpose of the article is to develop software that allows you to automatically check the print template file for all key parameters using information from its own database. The article is recommended to specialists whose work is related to the creation of documents in «FastReport».
DESIGN OF THE FUNCTIONAL MODULE «BUSINESS TRIP» ON THE BASIS OF THE ECM-SYSTEM OF PLATFORM DIRECTUM
Authors: Rabovskaya Maria Ya. , Smirnova Olga N.
Published: December 2023

The article discusses the automation of the business process of issuing a business trip based on the ECM system of platform solutions Directum using the example of an Russian organization engaged in energy sales activities. The purpose of the article is to design a module that will allow an employee to arrange a business trip without visiting the office, taking into account all the features of the legislative and regulatory framework and the capabilities of the corporate system.

The article is recommended to specialists whose work is related to the design of personnel workflow in the company.
MATHEMATICAL DESCRIPTION OF THE PROCESSES OF FUNCTIONING OF THE ELECTRIC MOTOR-GENERATOR OF A CAR WITH A HYBRID POWER PLANT
Authors: Kiselev Pavel A. , Fedotov Alexander I. , Yankov Oleg S.
Published: December 2023

The authors of the article describe and analyze the processes of functioning of a synchronous electric motor-generator (EDG). A review of mathematical descriptions of synchronous EDG is presented. A simplified mathematical description is proposed that makes it possible to simulate the process of functioning of the hybrid propulsion system (GSU) in typical modes of movement of wheeled vehicles (CTS). The functional dependences of the current, power and torque on the rotor speed of the synchronous EDG of the Toyota Prius car are presented.

The goal is to develop a simplified mathematical description of a synchronous electric motor–generator of a car with a hybrid power plant.

The method or methodology of the work is a numerical method based on the finite – difference scheme of the Park method, using a special numerical-iterative method of composing equations of motion.

Results – a simplified mathematical description has been developed, which allows to determine the functional dependencies necessary for the analysis of the functioning of the CCC with GSU.

The scope of the results. It is advisable to apply the results obtained when modeling the processes of functioning of a synchronous electric motor-generator of a hybrid power plant of wheeled vehicles.
VIRTUAL APPLICATION FOR MULTIMODAL TOURIST PASSENGER TRANSPORTATION
Authors: Pokrovskaya Oksana D. , Rodneva Ekaterina S. , Ivanov Danila S. , Vorobyov Alexander A. , Urushev Sergey V.
Published: December 2023

Background. This article identifies the main tourist centers of the Arkhangelsk region; developed options for tourist routes and additions to tours; describes the specifics of the application; assessed the relevance of the application for JSC “Russian Railways” and third-party organizations.

Materials and methods. Methods of mathematical modeling, system analysis, comparison, systems theory, visualization, observation, statistical method were used.

Results: it is established that the development of the scientific and technological potential and the innovative ecosystem of the holding allows ensuring the effectiveness of the company’s activities taking into account technical, technological, economic, socio-political challenges in the domestic and foreign markets.

Conclusion. The article proposes the concept of a virtual platform in the field of passenger multimodal transportation, where the passenger himself could prepare a tourist trip taking into account individual needs.
ANALYSIS OF LOGISTICS RISKS IN MODERN CONDITIONS
Authors: Pakulina Elena V. , Pokrovskaya Oksana D. , Migrov Alexander A.
Published: December 2023

Background. The article is devoted to the analysis of the state of the transport and logistics system of Russia in the context of the sanctions policy of the West, the classification of logistics chains, the identification of factors and risks affecting the stability of logistics flows in modern conditions.

Materials and methods. Materials from open Internet sources, logistics theory, systems theory, systems approach, comparison were used.

Results. An analytical review of the situation of Russia’s transport and logistics systems in the context of sanctions imposed by Western countries in 2022 was carried out. The risks affecting or capable of affecting the development and sustainability of logistics chains are identified.

Conclusion. Based on the results of the study, a new classification of logistics chains is proposed, taking into account changes in the construction of the logistics business, as well as a new standard logistics chain operating under sanctions.
SYSTEM ANALYSIS OF MAINTENANCE OF THE ELECTRICAL COMPLEX
Authors: Avetisyan Tatiana V. , Lvovich Jakov E. , Preobrazhenskiy Andrey P.
Published: December 2023

Modern electronic devices are characterized by complex circuit design solutions, which requires performing their design using high-performance circuit design computer-aided design systems. The development of such computer-aided design systems is associated with significant expenditure of time and labor resources and should be based on new approaches to the construction of mathematical and software, taking into account the specific features of the subject area and the nature of the tasks to be solved. In this paper, the problems associated with the modeling of maintenance of electrical complex are considered. A methodology for predicting components based on a single attribute within an experiment is demonstrated. The criterion in terms of risk assessment for the consumer is considered. The results of modeling the main parameters characterizing the quality of electrolytic capacitors are presented. After the tests are completed, the value of the predicted parameter is determined for each realization. The optimum value of leakage current, providing the minimum probability of error, for tantalum electrolytic capacitors with nominal capacity is shown. The results of the research can be useful for specialists working on electrical engineering complexes.
VOICE INFORMATION IN JSC “RUSSIAN RAILWAYS”
Authors: Yarmolinsky Fyodor A. , Pokrovskaya Oksana D. , Melikov Marat I.
Published: December 2023

Background. The work is devoted to the study of the processes of interaction between the company and consumers within the framework of the information services provided in order to improve or innovate the methods of voice communication for further operation and automation; as well as to substantiate the need for local research through the growth of automation of interaction and the speed of obtaining and perception of information.

Materials and methods. Materials from open sources on the Internet, simulation modeling, data analysis, systems theory, system approach.

Results. Information systems at Russian Railways using voice information methods have been studied, the area within which automation of user interaction with the system is possible has been analyzed, a simulation model of customer interaction with the system using voice information has been built to ensure the issuance of information on request.

Conclusion. Based on the results of the study, a solution was proposed for automation in the field of event-based informing of customers using the transport services of Russian Railways, company employees in order to improve information processing and automation of work with it. The proposed model will demonstrate and justify the issuance, processing and transmission of information for the transition to the introduction of voice information, through an assessment of the perception and reaction of the company’s employees to the implementation of audio accompaniment and interaction with the system through voice. As a result, it is proposed to develop a model reflecting the possibility of working with an information system using voice guidance and information.
EFFICIENCY OF THE ORGANIZATION OF THE MAINTENANCE POINT AT THE RAILWAY STATION
Authors: Pakulina Elena V. , Pokrovskaya Oksana D. , Migrov Alexander A.
Published: December 2023

Background. The article is devoted to the description of the design modeling of the brake testing point with its further modernization into a maintenance point at a passenger station in the St. Petersburg transport hub.

Materials and methods. Materials from open Internet sources, logistics theory, systems theory, systems approach, project modeling, economic justification, comparison “as is” and “as will be” were used.

Results. Based on the results of the analysis of the average downtime of one train during maintenance at the service station, the economic effect was determined.

Conclusion. Based on the results of the study, a solution was proposed for the organization of a maintenance point at the St. Petersburg – Finlandsky railway station with an appropriate feasibility study. With the application of the proposal, it is possible to improve the quality performance of the railway and optimize costs. It has been established by calculation that the presence of a technical service point at the St. Petersburg – Finlyandsky railway station will allow trains to move along a given route without the need for a secondary technical inspection at the St. Petersburg – Sortirovochny – Moskovsky station.
AUTOIMPORT OF A LARGE VOLUME INFORMATION INTO A DATABASE USING THE PYTHON PROGRAMMING LANGUAGE
Authors: Krapivin Roman R. , Filatov Yuri M. , Gareeva Gulnara A. , Faizullina Aigul G. , Myshkina Irina Yu.
Published: December 2023

The article discusses an efficient and automated way to import large amounts of data from Excel tables into a database. In various projects, there are tasks in which the flow of huge data, such as logs of program operations or manual operations performed at work sites, is vital for effective analysis.

Purpose – development of a module for automatic import of a large amount of data from Excel format into a database.

Method or methodology of work: the article discusses a method that implements automatic import of data from Excel tables into a Postgresql database.

Result: developed its own unique module that is able to process huge Excel tables and import them into a Postgresql database without manual operations.

Scope of the results: the data obtained, which are stored in the database, should be used to identify high-yield accounts for subsequent investment.
INFLUENCE OF SHOCK ABSORBER PROPERTIES ON TIRE LATERAL FORCE
Authors: Tikhov-Tinnikov Dmitry A.
Published: December 2023

The article examines how the damping properties of the suspension system of a vehicle affect the process of forming a lateral reaction in the contact patch of a tire and the supporting surface. A mathematical model of a car quarter, a tire stretched string model, and a road surface microprofile generator were used in the study. The dependences of normal and lateral reactions along the distance traveled for three classes of roads were obtained with a change in the parameter characterizing the damping properties of the vehicle suspension. Mathematical statistics methods were used to analyze the dependences. It was found that the average value of the normal load changes little with a decrease in the damping properties of the suspension, while the standard deviation increases. The average value of the lateral force is reduced by 22%, with the standard deviation increasing by 1.6 times. The use of the Kolmogorov-Smirnov criterion for the analysis of implementations of lateral forces makes it possible to determine the permissible range of nominal values of the parameters of the technical condition of vehicle suspension shock absorbers.

Purpose. Obtaining and analyzing patterns that describe the change in the lateral reaction of a car tire when it moves under the action of a lateral force and suspension vibrations, as well as when changing the damping properties of a shock absorber.

Methodology. In the article were used the methods of mathematical modeling and also statistical methods of the analysis.

Results. Dependences have been obtained that characterize the influence of the damping properties of the suspension on the magnitude of the lateral reaction when the wheel moves along a road with bumps and under the action of a lateral force.

Practical implications. It is expedient to apply the received results by the organizations and institutions involved in the development of methods and means of diagnosing vehicles.
APPLICATION OF GAME MODELS IN THE MANAGEMENT OF CYBER-PHYSICAL SYSTEMS
Authors: Avetisyan Tatiana V. , Lvovich Jakov E. , Preobrazhenskiy Andrey P.
Published: December 2023

Cyber-physical systems (CPS), along with cyber-biological and cybersocial systems, have recently become one of the key elements of modern infotelecommunications systems. The Internet of Things, as a revolutionary concept of the past few years, is a fundamental concept in the context of SPS. However, unlike the Internet of Things, which primarily emphasizes machine-to-machine connections, the SPS concept is based on the dualism of physical and cybernetic (information) environments. Turning to the applied field, we should note the trend towards informatization of many elements of the world around us. The degree of penetration ranges from sensors transmitting information about the state of a living organism to precise models describing the current state of an element within a smart production. This paper deals with the problem related to the control of cyber-physical systems under conditions where various random external influences are exerted on them. On the basis of game theory, the paper proposes, taking into account various criteria, to carry out the choice of control. Examples of calculations are considered.
EXPERIMENTAL STUDY OF THE PERFORMANCE CHARACTERISTICS OF SHOCK ABSORBERS
Authors: Batjargal N. , Tikhov-Tinnikov Dmitry A. , Fedotov Alexander I.
Published: December 2023

The article discusses the methodology for determining the performance characteristics of Toyota Prius 20 shock absorbers. The study was conducted using a stand for the diagnosis of shock absorbers developed by the Department of Road Transport of INRTU (Irkutsk National Research Technical University). Tests were carried out for five front suspension shock absorbers, one – a new serviceable shock absorber, the rest – shock absorbers that were previously in operation. The experimental dependences of the change in the resistance force of the shock absorber on the speed of movement of its rod are analyzed. The level of operational characteristics of the shock absorber under study was determined by comparing the obtained parameters with the parameters of the new shock absorber.

The results of experimental studies are presented in the form of operational characteristics of tested shock absorbers and indicators that determine the level of operational characteristics of shock absorbers. The developed methods and the equipment implementing them make it possible to determine the functional dependencies and the level of performance of shock absorbers that were in the operating conditions of the vehicle.