bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Z5.8‐dependence of viscosity of polymer rings over the range 15 < Zw ≤ 300 of the entanglement number
Authors: Ngai K. L.
Published: October 2023

Dynamic moduli G* and zero‐shear viscosity ηo,ring data in both melt and solution states were reported for putative cyclic poly(3,6‐dioxa‐1,8‐octanedithiol) (RDODT) with molecular weights ranging from 43 to 556 kg/mol. Measurements over wide temperature ranges provide up to 18 decades of reduced frequency to characterize RDODT melts and solutions with Zw = Mw/Me,lin from 23 to 300, where Mw is the weight average molecular weight and Me,lin ≈ 1850 g/mol is the entanglement molecular weight of the linear counterparts (LDODT). The G* of all the seven RDODT melts and eight of their solutions with Zw > 15 all have a rubbery plateau with the plateau moduli about same as GNo of the corresponding LDODT. The value Zw ≈ 15 marks the threshold for the change in scaling of ηo,ring from the Rouse‐like ηo,ring ∼ Zw1.0 to a much stronger dependence of ηo,ring ∼ Zw5.8 for Zw up to 300. Such a Zw5.8‐dependence has not been seen before in cyclic polymers and cannot be accounted for by current theoretical models for cyclic polymers. The Coupling Model had been used before to explain the Mw3.4 ‐dependence of linear entangled polymers and the stronger Mw ‐dependence of multi‐arm star branched polymers. It is applied to cyclic RDODT melts and solutions and the results provide an explanation of the observed Zw5.8‐dependence of ηo,ring.
Memristors Constructed by CsPbIBr2 Inorganic Halide Perovskite for Artificial Synapse and Logic Operation
Authors: Long Yan , Chen Xiang , Pan Xiaoxin , Duan Jinxia , Li Xiaoqing , Wu Yongcheng , Tang Jie , Ma Guokun , Shen Liangping , Zhang Jun , Wang Hao
Published: October 2023

Neuromorphic devices are one of the promising electronic devices that are implementing artificial neural networks and substituting for traditional semiconductor devices in recent years. Inorganic halide perovskite (IMHP) is considered as an advantageous material to constitute neuromorphic components. Herein, the CsPbIBr2 memristor displays superior resistive‐switching properties under various temperature and storage periods. In addition, synaptic plasticity, including paired pulse facilitation and spiking timing‐dependent plasticity, is observed for CsPbIBr2 device, whose resistance manipulation is also established in both DC and pulse modes. Moreover, the decimal operation function of numbers by applying pulse stimulation to the device to regulate the device conductance is realized. This work demonstrates the feasibility of IMHP in neuromorphic devices, accelerating the application of neuromorphic computing.
Comprehensive exploration of Biochanin A as an oncotherapeutics potential in the treatment of multivarious cancers with molecular insights
Authors: Sohel Md
Published: October 2023

Cancer is considered a leading cause of mortality. This rising cancer death rate and several existing limitations like side effects, poor efficacies, and high cost of the present chemotherapeutic agents have increased the demand for more potent and alternative cancer treatments. This review elucidated a brief overview of Biochanin A (BCA) and its potentiality on various cancers with details of anticancer mechanism. According to our review, a number of studies including in silico, in vitro, pre‐clinical, and clinical trials have tested to evaluate the efficacy of BCA. This compound is effective against 15 types of cancer, including breast, cervical, colorectal, gastric, glioblastoma, liver, lung, melanoma, oral, osteosarcoma, ovarian, pancreatic, pharynx, prostate, and umbilical vein cancer. The general anticancer activities of this compound are mediated via several molecular processes, including regulation of apoptosis, cell proliferation, metastasis and angiogenesis, signaling, enzymatic pathways, and other mechanisms. Targeting both therapeutic and oncogenic proteins, as well as different pathways, makes up the molecular mechanism underlying the anticancer action. Many signaling networks and their components, such as EFGR, PI3K/Akt/mTOR, MAPK, MMP‐2, MMP‐9, PARP, Caspase‐3/8/9, Bax, Bcl2, PDL‐1, NF‐κB, TNF‐α, IL‐6, JAK, STAT3, VEGFR, VEGF, c‐MY, Cyclin B1, D1, E1 and CDKs, Snail, and E‐cadherin proteins, can be regulated in cancer cells by BCA. Such kind of anticancer properties of BCA could be a result of its correct structural chemistry. The use of BCA‐based therapies as nano‐carriers for the delivery of chemotherapeutic medicines has the potential to be very effective. This natural compound synergises with other natural compounds and standard drugs, including sorafenib, 5‐fluorouracil, temozolomide, doxorubicin, apigenin, and genistein. Moreover, proper use of this compound can reverse multidrug resistance through numerous mechanisms. BCA has better drug‐likeness and pharmacokinetic properties and is nontoxic (eye, liver, kidney, skin, cardio) in human bodies. As having a wide range of cancer‐fighting mechanisms, synergistic effects, and good pharmacokinetic properties, BCA can be used as a supplementary food until standard drugs are available at pharma markets.
Targeting EBV‐encoded products: Implications for drug development in EBV‐associated diseases
Authors: Lv Mengwen , Ding Yuan , Zhang Yan , Liu Shuzhen
Published: October 2023

Epstein‐Barr virus, a human gamma‐herpesvirus, has a close connection to the pathogenesis of cancers and other diseases, which are a burden for public health worldwide. So far, several drugs or biomolecules have been discovered that can target EBV‐encoded products for treatment, such as Silvestrol, affinity toxin, roscovitine, H20, H31, curcumin, thymoquinone, and ribosomal protein L22. These drugs activate or inhibit the function of some biomolecules, affecting subsequent signalling pathways by acting on the products of EBV. These drugs usually target LMP1, LMP2; EBNA1, EBNA2, EBNA3; EBER1, EBER2; Bam‐HI A rightward transcript and BHRF1. Additionally, some promising findings in the fields of vaccines, immunological, and cellular therapies have been established. In this review, we mainly summarise the function of drugs mentioned above and unique mechanisms, hoping that we can help giving insight to the design of drugs for the treatment of EBV‐associated diseases.
The H∞‐optimal control problem of CSVIU systems
Authors: Campos Daniel S. , do Val João B. R.
Published: October 2023

The article devises an ‐norm theory for the CSVIU (control and state variations increase uncertainty) class of stochastic systems. This system model appeals to stochastic control problems to express the state evolution of a possibly nonlinear dynamic system restraint to poor modeling. It introduces the control with infinity energy disturbance signals, contrary to usual stochastic formulations, which mimic deterministic models dealing with finite energy disturbances. The reason is to portray the persistent perturbations due to the environment more naturally. In this regard, it develops a refined connection between a notion of stability and the system's power finiteness. It delves into the control solution employing the relations between optimization and differential games, connecting the worst‐case stability analysis of CSVIU systems with a perturbed Lyapunov type of equation. The norm characterization relies on the optimal cost induced by the min–max control strategy. The solvability of a generalized game‐type Riccati equation couples to the rise of a pure saddle point, yielding the global solution of the CSVIU dynamic game. In the way to the optimal stabilizing compensator, the article finds it based on linear feedback stabilizing gain from solving the Riccati equation together with a spectral radius test of an ensuing matrix. The optimal disturbance compensator produces inaction regions in the sense that, for sufficiently minor deviations from the model, the optimal action is constant or null in the face of the uncertainty involved. Finally, an explicit solution approximation developed by a Monte Carlo method appears, and a numerical example illustrates the synthesis.
Stability analysis of switched stochastic nonlinear functional systems
Authors: Peng Haiqi , Zhu Quanxin
Published: October 2023

This article is concerned with stochastic finite time stability (SFTS) and stochastic fixed time stability (SFIXTS) of switched stochastic nonlinear functional systems. By using the Lyapunov–Razumikhin approach, stochastic analysis techniques, and stochastic process theory, several novel theorems on SFTS and SFIXTS are established. Concurrently, the estimations of stochastic settling time are given. Different from the previous general results, this article considers the effects of noise, time‐delays, and switches. The SFTS and SFIXTS conditions are established, which are quite different from the traditional exponential stability or almost sure stability. Furthermore, two examples are given to illustrate the effectiveness of the obtained results.
Reflections on energy, information and fields from psychoanalytic and systems theoretical perspectives
Authors: Buckle Pamela M.
Published: October 2023

The story of energy as a focus of psychoanalysis began with Freud and was conceptualized further by C. G. Jung. For him, energy enlivens the human psyche, drawing people towards ideas and activities, forming and re‐forming us through the ways it moves and the content it carries. This article examines how psychological energy forms the experience of individuals, informing us about conscious and subconscious states of the human psyche as it engages with its environment. We examine how psychological energy forms the experience of groups, creating qualitatively linked behaviours, constraints and potentials that Jung and others conceived of as psychological ‘fields’. The concept of energy as a property of psychological systems contributes to our understanding of the human experience. Though rarely conscious, it impacts the phenomenological experience of both individuals and groups, who cope with it in both generative and destructive ways.
Evaluation of Molten Steel Flow Behaviors in a Multistrand Tundish via Numerical Simulation and Grey Relational Analysis with a New Dimensionless Operator
Authors: Wu Di , Liu Junda , Wu Dongling , Zhou Ping
Published: October 2023

Optimizing the tundish structure can effectively improve billet or solid product quality. The correlation between the structural parameters of the baffle and the flow characteristics of molten steel in a tundish is a prerequisite for tundish structural optimization. In this study, molten steel flow behaviors are stimulated in a five‐strand tundish using computational fluid dynamics. The behaviors are characterized by the dead‐zone ratio of the entire tundish and the flow consistency of five strands at the outlets. Further, the influences of different structural parameters on the characteristics are analyzed, and the degree of influence is evaluated using grey relational analysis (GRA). Four traditional nondimensionalization operators are used for GRA. However, the results obtained from different operators are inconsistent. Therefore, a benchmark deviation dimensionless operator is proposed to improve the accuracy of GRA. The improved grey correlation degrees are consistent with the results obtained through numerical simulation. The rank of the grey correlation degree indicates that the diameter and inclination angle of Orifice B, which is at the lower position of the baffle, are highly correlated with the dead‐zone ratio. The inclination angles should have a larger correlation degree for flow consistency than the orifice diameter.
Effect of Cr–Mo Addition on the Microstructure and Mechanical Properties of Medium‐Carbon Steel
Authors: Qi Min , Wu Hongyan , Du Linxiu , Gao Xiuhua , Zhang Xiaolei , Zhang Zhixin , Zhang Mingbo
Published: October 2023

Herein, the effects of Chromium–Molybdenum (Cr–Mo) addition on the microstructural evolution and mechanical properties of medium‐carbon steel after spheroidization annealing are systematically studied through scanning electron microscopy, electron backscatter diffraction, and tensile testing. Cr–Mo addition hinders the proeutectoid ferrite + pearlite transformation, thereby promoting the bainite transformation. Moreover, it refines the pearlite lamellar spacing as well as decreases the average carbide diameter, increases the number of carbides per unit area, and hinders ferrite recrystallization. Compared with those in the B1 steel annealed for 8 h, the size of carbides and their number per unit area in the CM1 steel are 30% lower and 2.2‐fold higher, respectively. Due to finer ferrite grains, smaller carbides, and a higher amount of carbides, the strength of steel improves, and the plasticity slightly reduces after Cr–Mo addition. After 2 h of annealing, the yield strengths of Cr–Mo steels are 77.5–109.5 MPa higher than those of base steels; the elongations are above 20%. The contributions of the strengthening mechanism of steel to the yield strength are as follows (from high to low): grain boundary, precipitation, solid solution, and dislocation strengthening.
Review of green technologies for the removal of microplastics from diverse environmental sources
Authors: Namasivayam S. Karthick Raja , Avinash G. P.
Published: October 2023

Microplastics are the basic particles (1 µm–1 mm), derived from degradation of polymers with maximum molecular weight via various sources. They occur in a variety of shapes and sizes, in the form of domains, particles, and fibers. Release of Microplastics in the ecosystem, due to deterioration of macroplastics are now being considered as major toxic pollutants. Accumulation of microplastics in the diverse ecosystems is known to cause severe health and ecological effects. Since it is mandatory to take steps towards the removal of microplastics through effective and safe technology, with this objective, the present study is undertaken to reveal various green technology principles for the management of microplastics contamination associated with diverse environmental sources. This strategy involves physical methods, chemical methods, biological methods that under the conventional measures and nanotechnology principles as modern remediation. Physical methods involve filtration, membrane‐technology and adsorption. Chemical remediation involves hydrolysis, alcoholysis, acidolysis, glycolysis, aminolysis, photocatalytic degradation and electrochemical oxidation resulting in decomposition of microplastics into simpler, non‐toxic end products. Biological methods involve biosorption, microbial degradation, microbial ingestion and phytoremediation, where plants or plant biomass can be used for removal of microplastics via phytoaccumulation, phytostabilization, phytovolatilization and phytofiltration. Nano technology remediation utilizes nanoscale materials as adsorbents. Due to its unique nanosize, high surface area and energy, nanomaterials are considered effective adsorbents of microplastics. Microplastics can also be detected and identified using machine learning approaches. The present study implies that, the green technology principles can be effectively utilized for the removal of microplastics associated with diverse ecosystem.
Disseminated histoplasmosis in an imported Maine Coon cat in western continental Europe
Authors: Burgers Elisabeth M. , Santarelli Giorgia , Bergmann Wilhelmina , Meijer Eelco F. J. , Veraa Stefanie
Published: October 2023

A 4‐year‐old, male, neutered Maine Coon presented with a 9‐month history of weight loss, tachypnoea, dyspnoea and lethargy. The patient had been in the owner's possession since kittenhood in Texas, and 20 months before presentation had moved to Europe, living first in France and then the Netherlands. A bronchoalveolar lavage performed by the referring veterinarian cultured positive for Mycoplasma (unknown species), and treatment was initiated with minimal response. Sequential referring radiographs showed progressive diffuse pulmonary broncho‐interstitial changes. At presentation, focused echocardiogram suggested moderate likelihood of pulmonary hypertension. Repeat thoracic radiographs showed markedly progressed pulmonary changes, with a new miliary component. Bloodwork showed hypergammaglobulinaemia. Pending additional diagnostic results, the patient passed away within 4 days. Postmortem examination was compatible with severe chronic pyogranulomatous pneumonia with pleuritis, splenitis, hepatitis and adrenalitis, with histopathological identification of intracytoplasmic fungal elements. Sequencing of pulmonary granulomatous tissue confirmed the presence of Histoplasma capsulatum.
An evaluation of DNA sample source and molecular markers to determine gender in the short‐beaked echidna (Tachyglossus aculeatus)
Authors: Hulse Lyndal , Tomsett Caitlin , Roser Alice , Clark Lauren , Meer Haley , Pyne Michael , Fenelon Jane C. , Renfree Marilyn B. , Johnston Stephen
Published: October 2023

The short‐beaked echidna is sexually monomorphic such that gender identification without veterinary intervention is challenging. The aim of this study was to evaluate and compare the most optimal noninvasive genetic source by extracting echidna genomic DNA (gDNA) from fecal scats, plucked hair, and quills to perform genetic sex testing using a range of molecular markers. Sex determination of 14 captive short‐beaked echidnas was determined by amplifying isolated DNA from noninvasive samples, targeting two Y chromosome (male‐specific) genes (mediator complex subunit 26 Y‐gametologue [CRSPY] and anti‐Müllerian hormone Y‐gametologue [AMHY]), in addition to four confirmed sex‐specific RADseq markers. Results of noninvasive samples were compared with blood samples and clinical records. Receiver operating characteristic curves were used to assess accuracy of sex determination of markers for each sample type. The gender of the echidnas was successfully identified on 75% of occasions using fecal samples, 90.6% occasions using hair, and 84.6% occasions with quills. Overall, the male‐specific RADseq markers accurately identified the sex of echidnas with all sample types for 90% of animals; compared with 81.5% using CRSPY, and 82.0% using AMHY to identify sex. Collection of hair, quills, and feces provides a useful alternative to invasively collected samples, however, the accuracy of results depends on sample type and genetic marker selected. We found gender determination in the short‐beaked echidna was most accurate using four male‐specific RADseq markers on gDNA isolated from blood and hair. The noninvasive genetic sexing techniques documented here will inform and facilitate husbandry and genetic management of captive echidna populations.
Probing proton structure with $$ \textrm{c}\overline{\textrm{c}} $$ correlations in ultraperipheral pA collisions
Authors: Linek Barbara , Łuszczak Agnieszka , Łuszczak Marta , Pasechnik Roman , Schäfer Wolfgang , Szczurek Antoni
Published: October 2023

Abstract

We study the exclusive diffractive $$ c\overline{c} $$
c

c
¯

photoproduction in ultraperipheral pA collisions. The formalism makes use of off-diagonal generalizations of the unintegrated gluon distribution, the so-called generalized transverse momentum dependent distributions (GTMDs). We present two different formulations. The first one is based directly on gluon GTMD parametrizations in momentum space. Another option is the calculation of the GTMD as a Fourier transform of the dipole-nucleon scattering amplitude N(Y, $$ \overrightarrow{r} $$

r
→

⊥, $$ \overrightarrow{b} $$

b
→

⊥). The latter approach requires some extra regularization discussed in the paper. Different dipole amplitudes from the literature are used. Compared to previous calculations in the literature, we integrate over the full phase space and therefore cross sections for realistic conditions are obtained. We present distributions in rapidity of c or $$ \overline{c} $$

c
¯

, transverse momentum of the $$ c\overline{c} $$
c

c
¯

pair, four-momentum transfer squared as well as the azimuthal correlation between a sum and a difference of the c and $$ \overline{c} $$

c
¯

transverse momenta. The azimuthal correlations are partially due to the so-called elliptic gluon Wigner distribution. Different models lead to different modulations in the azimuthal angle. The modulations are generally smaller than 5%. They depend on the range of transverse momentum selected for the calculation.
Marginal deformations of Calabi-Yau hypersurface hybrids with (2,2) supersymmetry
Authors: Adams Griffen , Melnikov Ilarion V.
Published: October 2023

Abstract

We study two-dimensional non-linear sigma models with (2,2) supersymmetry and a holomorphic superpotential that are believed to flow to unitary compact (2,2) superconformal theories with central charges cL = cR = 9. The SCFTs have a set of marginal deformations, and some of these can be realized as deformations of parameters of the UV theory, making it possible to apply techniques such as localization to probe the deformations of the SCFT in terms of a UV Lagrangian. In this work we describe the UV lifts of the remaining SCFT infinitesimal deformations, the so-called non-toric and non-polynomial deformations. Our UV theories naturally arise as geometric phases of gauged linear sigma models, and it may be possible to extend our results to find lifts of all SCFT deformations to the gauged linear sigma model.
The role of interface configuration on performance accuracy in eyes-free touchscreen interaction
Authors: Pooripanyakun Munyaporn , Wodehouse Andrew , Mehnen Jorn
Published: October 2023

This paper describes the exploration of a new category of a touchscreen interface. An eyes-free interface harnesses innate human abilities and product affordances to allow reduced levels of visual attention. Interface design for eyes-free interaction with a featureless screen is highly challenging; however, it can be achieved by simplifying and optimizing menu layout patterns to take advantage of innate human abilities including proprioception and spatial memory. This opens up a range of possibilities for peripheral device control under one-handed thumb mobile interaction. To this end, two experiments with different modes of presentation were conducted to understand the effect of interface configurations on performance accuracy caused by spatial memory and proprioception. Spatial performance results from the interaction effect of both cognitive abilities on an eyes-free interface. Vertical, horizontal, diagonal, and curved layouts with different spacing patterns have been tested in both tap and draw input modes. The results revealed that evenly spaced button alignment close to the reference frame with symmetrical patterns within a square interface area and a comfortable thumb range positively affect accuracy. The conclusions describe how alignment patterns and the mode of presentation affect visual perception and spatial integration, and a framework for the development of an eyes-free interface is set out.
A Comparative Study of Ex-Vivo Murine Pulmonary Mechanics Under Positive- and Negative-Pressure Ventilation
Authors: Quiros K. A. M. , Nelson T. M. , Ulu A. , Dominguez E. C. , Biddle T. A. , Lo D. D. , Nordgren T. M. , Eskandari M.
Published: October 2023

Increased ventilator use during the COVID-19 pandemic resurrected persistent questions regarding mechanical ventilation including the difference between physiological and artificial breathing induced by ventilators (i.e., positive- versus negative-pressure ventilation, PPV vs NPV). To address this controversy, we compare murine specimens subjected to PPV and NPV in ex vivo quasi-static loading and quantify pulmonary mechanics via measures of quasi-static and dynamic compliances, transpulmonary pressure, and energetics when varying inflation frequency and volume. Each investigated mechanical parameter yields instance(s) of significant variability between ventilation modes. Most notably, inflation compliance, percent relaxation, and peak pressure are found to be consistently dependent on the ventilation mode. Maximum inflation volume and frequency note varied dependencies contingent on the ventilation mode. Contradictory to limited previous clinical investigations of oxygenation and end-inspiratory measures, the mechanics-focused comprehensive findings presented here indicate lung properties are dependent on loading mode, and importantly, these dependencies differ between smaller versus larger mammalian species despite identical custom-designed PPV/NPV ventilator usage. Results indicate that past contradictory findings regarding ventilation mode comparisons in the field may be linked to the chosen animal model. Understanding the differing fundamental mechanics between PPV and NPV may provide insights for improving ventilation strategies and design to prevent associated lung injuries.
On two-stage analysis of multi-environment trials
Authors: Verbyla Arūnas
Published: October 2023

Two-stage analysis methods are often used in multi-environment trials (MET) for plant variety selection, when a single-stage approach is not feasible or too time consuming. In any two-stage analysis, the estimated effects taken to stage two must be unbiased for the effects of interest, and this means using best linear unbiased estimates based on a model with fixed genetic effects. The error (or weights) associated with the estimates must also be taken to stage two. These weights are functions of unknown variance parameters that need to be estimated at stage one. These parameters may be better estimated if genetic effects are taken as random, but resulting predicted genetic effects are biased. The bias can be removed by so-called de-regression in animal sciences. The proper weights involve a block diagonal matrix with blocks corresponding to environments, whereas diagonal weights were originally proposed in animal sciences. Two MET experiments, one fully replicated and one with partial replication of varieties, were used to compare one-stage and two-stage approaches. The results were similar, but using a full weight matrix for two-stage methods was superior to using diagonal weights. A small simulation study for trials with partial replication showed that fitting random genetic effects, de-regressing, and using a full weight matrix, was very similar to a one-stage analysis, and was superior to starting with fixed genetic effects at stage one. The use of diagonal weights was found to be very poor.
High-risk Victims of Intimate Partner Violence: An Examination of Abuse Characteristics, Psychosocial Vulnerabilities and Reported Revictimization
Authors: Tomkins Jordan , Jolliffe Simpson Apriel D. , Polaschek Devon L. L.
Published: October 2023

Purpose

To support service provision, we sought to advance the existing evidence base about the characteristics of—and potential predictors of reported revictimization for—women identified as being at high risk of experiencing ongoing intimate partner violence (IPV).

Method

Our sample included 165 high-risk IPV cases with a female victim and a male aggressor managed by the Integrated Safety Response in New Zealand. Based on police and multi-agency risk assessment information, we (a) described the characteristics of these cases, focusing on victims’ abuse experiences and psychosocial vulnerabilities; (b) examined rates of reported recurrence and physical recurrence; and (c) explored which variables predicted these two outcomes across a 12-month follow up, using the Nested Ecological Model as an organizing framework.

Results

In addition to experiencing harmful patterns of IPV, victims had relatively high rates of mental health issues, drug use, housing instability and unemployment. Reported revictimization was common: 62.8% of cases involved (at least one) recurrence, and 35.8% of cases involved physical recurrence. Most variables did not predict either outcome, and only two variables consistently predicted rates of recurrence and physical recurrence: strangulation and a victim’s initial engagement with IPV interventions.

Conclusions

As predicted, reported revictimization rates were high. Victims also experienced other psychosocial vulnerabilities, confirming their need for wide-ranging support. However, this study raises questions about whether these needs are relevant to predicting reported revictimization within high-risk cohorts, and highlights the difficulties of empirically validating treatment targets that could minimize further IPV harm for this group.
Explainable AI in drug discovery: self-interpretable graph neural network for molecular property prediction using concept whitening
Authors: Proietti Michela , Ragno Alessio , Rosa Biagio La , Ragno Rino , Capobianco Roberto
Published: October 2023

Molecular property prediction is a fundamental task in the field of drug discovery. Several works use graph neural networks to leverage molecular graph representations. Although they have been successfully applied in a variety of applications, their decision process is not transparent. In this work, we adapt concept whitening to graph neural networks. This approach is an explainability method used to build an inherently interpretable model, which allows identifying the concepts and consequently the structural parts of the molecules that are relevant for the output predictions. We test popular models on several benchmark datasets from MoleculeNet. Starting from previous work, we identify the most significant molecular properties to be used as concepts to perform classification. We show that the addition of concept whitening layers brings an improvement in both classification performance and interpretability. Finally, we provide several structural and conceptual explanations for the predictions.
Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen
Authors: Stroffolini Giacomo , Lazzaro Alessandro , Barco Ambra , Pirriatore Veronica , Vai Daniela , Giaccone Claudia , Nigra Marco , Atzori Cristiana , Trunfio Mattia , Bonora Stefano , Di Perri G Giovanni , Calcagno Andrea
Published: October 2023

The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in CSF biomarkers, Fibroscan and IMT measurements in PLWH with HAND randomized to a less neurotoxic regimen, or continuing their treatment. Adult patients with HAND were screened and enrolled if presenting no major resistance associated mutations, no HIV viral replication, not on efavirenz or darunavir, with R5-tropic HIV and without major confounding conditions. Lumbar puncture, IMT and Fibroscan measurements were performed. After 1:1 randomization to a less neurotoxic regimen consisting of darunavir/cobicistat plus emtricitabine plus maraviroc, or mantaining actual care, tests were repeated after 24 weeks: CSF biomarkes (HIV RNA, tau, p-tau, Beta-amyloid1-42, S100Beta and neopterin) were included. Non-parametric tests (Mann–Whitney and Wilcoxon’s) were used. 28 participants completed the study. Male and European ancestry were prevalent; median age was 55 years (51–60). All patients were virally suppressed; median CD4 + count was 626 cell/uL (469–772). Baseline characteristics were similar between the study arms. A significant decrease in CSF p-tau and an increase in CSF neopterin and NFL were observed. We observed a significant reduction in liver stiffness at W24. Despite a small sample size we observed changes in neuromarkers and in hepatic stiffness in patients randomized to the experimental arm. We observed changes in CSF biomarkers (lower phosphorylated-tau and higher neopterin and NFL) that need to be replicated in large cohorts. Subclinical neurotoxicity may be observed in patients with HAND and warrants prospective studies.

Graphical Abstract
CARE-full Online Service-Learning in the Digital Age: Overcoming TIP and FEAR to Maximize Community Partner Outcomes in the Philippines
Authors: Abenir Mark Anthony D. , Advincula-Lopez Leslie V. , Mendoza Lara Katrina T. , Panlilio Eugene G.
Published: October 2023

This study investigates the outcomes of online Service-Learning (SL) in Philippine partner communities, addressing a literature gap on predominantly face-to-face (f2f) SL. Applying the Conceptual Framework of Community Impacts Arising from Service-Learning, it employs a mixed-method convergent design to assess the benefits, drawbacks, and influential factors of online SL’s effectiveness (CARE, TIP, and FEAR). Data, sourced from 101 survey participants across 46 Community Partner Organizations (CPOs) in affiliation with Ateneo de Manila University, is complemented by the insights derived from 22 comprehensive interviews with key community contact persons. Findings reveal that online SL bolsters CPOs’ missions, enhance resources, facilitates knowledge transfer, and yields positive outcomes. However, barriers such as Time management challenges, Infrastructure and technical hurdles, and Participation obstacles (TIP), along with its consequent drawbacks such as difficulty in providing timely and effective Feedback, disparity in varying levels of Effort displayed by students, erosion of Authentic relationships in prolonged virtual engagements, and Repetitiveness and nonfulfillment concerns (FEAR) were identified as challenges. Despite these, Collaborative coordination, Active communication, Responsiveness to CPO’s needs, and Engaging online environment (CARE) were recognized as key enablers. This research highlights the significance of examining the outcomes of online SL from the perspective of community partners, informing best practices for implementation, and cultivating effective online SL collaborations that can be adapted across various countries with similar contexts.
Performance analysis of optimized versatile video coding software decoders on embedded platforms
Authors: Saha Anup , Hamidouche Wassim , Chavarrías Miguel , Pescador Fernando , Farhat Ibrahim
Published: October 2023

In recent years, the global demand for high-resolution videos and the emergence of new multimedia applications have created the need for a new video coding standard. Therefore, in July 2020, the versatile video coding (VVC) standard was released, providing up to 50% bit-rate savings for the same video quality compared to its predecessor high-efficiency video coding (HEVC). However, these bit-rate savings come at the cost of high computational complexity, particularly for live applications and on resource-constrained embedded devices. This paper evaluates two optimized VVC software decoders, named OpenVVC and Versatile Video deCoder (VVdeC), designed for low resources platforms. These decoders exploit optimization techniques such as data-level parallelism using single instruction multiple data (SIMD) instructions and functional-level parallelism using frame, tile, and slice-based parallelisms. Furthermore, a comparison of decoding runtime, energy, and memory consumption between the two decoders is presented while targeting two different resource-constraint embedded devices. The results showed that both decoders achieve real-time decoding of full high-definition (FHD) resolution on the first platform using 8 cores and high-definition (HD) real-time decoding for the second platform using only 4 cores with comparable results in terms of the average energy consumed: around 26 J and 15 J for the 8 cores and 4 cores platforms, respectively. Furthermore, OpenVVC showed better results regarding memory usage with a lower average maximum memory consumed during runtime than VVdeC.
Parental Divorce in Childhood and the Accelerated Epigenetic Aging for Earlier and Later Cohorts: Role of Mediators of Chronic Depressive Symptoms, Education, Smoking, Obesity, and Own Marital Disruption
Authors: Kim Jung Ki , Arpawong Thalida Em , Klopack Eric T. , Crimmins Eileen M.
Published: October 2023

We examine effects of parental divorce on epigenetic aging in later adulthood for two birth cohorts: one born in the early 20th century and the other born in the later 20th century. Using data from the Health and Retirement Study (n = 1,545), we examine the relationship between parental divorce in childhood and accelerated epigenetic aging in older adulthood as indicated by the Dunedin methylation Pace of Aging score. We assess how this relationship is mediated by chronic depressive symptoms, education, lifetime smoking, body mass index (BMI), and an older adult’s own divorce. The mean age of the earlier cohort is 85.8 (SD = 3.9) and that of the later cohort is 60.2 (SD = 2.8). We find that parental divorce was related to faster aging in the later-born cohort, and that 56% of this relationship (b = 0.060) was mediated by chronic depressive symptoms (b = 0.013), lower education levels (b = 0.005), and smoking (b = 0.019). For the earlier cohort, there was no effect of parental divorce on epigenetic aging. Parental divorce in childhood may have lasting effects on later-life health, as reflected in the rate of epigenetic aging. However, the effects and mechanisms of this relationship differ across cohorts living in different social environments.
Is there a blast radius of workplace bullying? Ripple effects on witnesses and non-witnesses
Authors: Rosander Michael , Nielsen Morten Birkeland
Published: October 2023

Substantial evidence points to detrimental effects of workplace bullying on the health, well-being and job attitudes among those exposed. What is less known is how bullying affects their non-exposed colleagues. In this study, we introduce the concept “blast radius of bullying” and use social information processing theory to investigate how bullying impacts targets, witnesses, and non-witnesses. We suggest three mechanisms to understand the impact bullying may have on non-targets: the working environment mechanism, secondary victimization, and emotional contagion. We hypothesized that non-exposed colleagues in groups where bullying exists would feel some impact of bullying, but that it would be smaller for those further away from the point of impact. We also investigated the association between the severity of mistreatment and outcomes for the above-mentioned categories. We used data (n = 2215) from 195 work groups. The results provided evidence for a blast radius of bullying, however, not as far-reaching as hypothesized as only direct observation of mistreatment was associated with negative outcomes. The severity of mistreatment was not associated with the outcomes, whereas the frequency of observation had some impact for witnesses. The study showed that also witnesses may be regarded as “co-victims”.
Upconversion luminescence and optical thermometry behaviors of Yb3+ and Ho3+ co-doped GYTO crystal
Authors: Zhang Chuancheng , Ding Shoujun , Wang Miaomiao , Ren Hao , Tang Xubing , Zou Yong , Dou Renqin , Liu Wenpeng
Published: October 2023

Optical thermometry based on the upconversion (UC) luminescence intensity ratio (LIR) has attracted considerable attention because of its feasibility for achievement of accurate non-contact temperature measurement. Compared with traditional UC phosphors, optical thermometry based on UC single crystals can achieve faster response and higher sensitivity due to the stability and high thermal conductivity of the single crystals. In this study, a high-quality 5 at% Yb3+ and 1 at% Ho3+ co-doped Gd0.74Y0.2TaO4 single crystal was grown by the Czochralski (Cz) method, and the structure of the as-grown crystal was characterized. Importantly, the UC luminescent properties and optical thermometry behaviors of this crystal were revealed. Under 980 nm wavelength excitation, green and red UC luminescence lines at 550 and 650 nm and corresponding to the 5F4/5S2 → 5I8 and 5F5 → 5I8 transitions of Ho3+, respectively, were observed. The green and red UC emissions involved a two-photon mechanism, as evidenced by the analysis of power-dependent UC emission spectra. The temperature-dependent UC emission spectra were measured in the temperature range of 330–660 K to assess the optical temperature sensing behavior. At 660 K, the maximum relative sensing sensitivity (Sr) was determined to be 0.0037 K−1. These results highlight the significant potential of Yb,Ho:GYTO single crystal for optical temperature sensors.

Graphical abstract
The Fragmented QRS Complex in Lead V1: Time for an Update of the Athlete’s ECG?
Authors: Vecchiato Marco , Quinto Giulia , Borasio Nicola , Palermi Stefano , Berton Giampaolo , Battista Francesca , Gasperetti Andrea , Ermolao Andrea , Neunhaeuserer Daniel
Published: October 2023

Differentiating between ECG patterns related to athletes' heart remodeling and pathological findings is a challenge in sports cardiology. As the significance of fragmented complex in athletes remains uncertain, this study aimed to assess the presence of fragmented QRS in lead V1 (fQRSV1) among young athletes and its association with heart adaptations and arrhythmias. Young athletes referred for annual pre-participation screening receiving a maximal exercise testing and transthoracic echocardiography from January 2015 to March 2021 were included. The study included 684 young athletes. The prevalence of fQRSV1 was 33%. Subjects with fQRSV1 had higher exercise capacity and indexes of right ventricular function and remodeling. Among highly trained athletes, the fQRSV1 group demonstrated also increased left ventricular wall thickness. No significant association existed between fQRSV1 and exercise-induced arrhythmias, even in highly trained athletes. The high prevalence of fQRSV1 in young athletes is associated with training-induced heart adaptations but not exercise-induced ventricular arrhythmias.

Graphical Abstract

The fragmented QRS complex in lead V1 in young athletes. PPS = preparticipation screening; EST = exercise stress test; fQRSV1 = fragmented QRS in lead V1; PSBs = premature supraventricular beats; PVBs = premature ventricular beats.
A Framework for Standardization of Distributed Ledger Technologies for Interoperable Data Integration and Alignment in Sustainable Smart Cities
Authors: Jnr. Bokolo Anthony , Sylva Waribugo , Watat Josue Kuika , Misra Sanjay
Published: October 2023

Distributed ledger technologies (DLTs) are considered one of the foremost emerging technologies which can contribute to transform cities to smarter cities. DLT play important role in municipalities to accelerate the digitalization process toward changing the roles and services of enterprises in sustainable smart cities. Standardization of DLTs aids to reduce data and digital assets silos while decreasing vendor lock-in across distributed applications enabling a digital urban ecosystem that supports migration capabilities making it possible for cities to seamlessly achieve interoperability among DLTs and centralized digital platforms, although a few standards such as IEEE 2418, IEEE P2418.5, and ISO/TC 307 have been developed. The alignment and integration mechanisms required to support standardization of DLT for interoperable services in smart cities is lacking. Therefore, this study presents an understanding on current and open issues on standardization of DLTs in sustainable smart cities with a specific focus on data integration and alignment efforts related to interoperable DLTs. A framework is developed to promote standardization of DLTs to support integration and alignment for interoperability in smart cities. Design science research methodology was adopted based on three use case scenarios which illustrates how IOTA tangle is employs as a DLT for secured standardized communication between physical sensors, devices, and digital platforms in smart city environment. Findings from this article provide exploratory evidence demonstrating the potential uses of IOTA tangle through the developed framework applied for decentralized and centralized digital services. Based on this evidence, this study provides interface integration and alignment strategies to better exploit distributed applications full potential by improving DLT standardization in urban environment.
Life Satisfaction and Affect: Why Do these SWB Measures Correlate Differently with Material Goods and Freedom?
Authors: de Boer Jelle
Published: October 2023

Two different types of subjective well-being (SWB) measures exhibit a remarkable difference in their correlations with people’s circumstances. The life satisfaction method shows relatively a strong correlation with income and material conveniences while affective measures are more tightly linked with freedom. Why is this so? To explain this difference I examine the cognitive mechanisms underlying these measures by means of dual process theory. This theory identifies two broad categories of cognition. One is Type 1: fast, intuitive, automatic and autonomous. The other is Type 2: slow, deliberate and under conscious control. (They are also known as System 1 and System 2). I argue that in our normal decision making there is a division of labor between these mechanisms. Type 2 is more focused on making choices, comparing material goods and tradeoffs between them, while Type 1 is more oriented at the freedom that is necessary to make those choices.
Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds
Authors: Han Xiaoyu , Saiding Qimanguli , Cai Xiaolu , Xiao Yi , Wang Peng , Cai Zhengwei , Gong Xuan , Gong Weiming , Zhang Xingcai , Cui Wenguo
Published: October 2023

Blood vessels are essential for nutrient and oxygen delivery and waste removal. Scaffold-repairing materials with functional vascular networks are widely used in bone tissue engineering. Additive manufacturing is a manufacturing technology that creates three-dimensional solids by stacking substances layer by layer, mainly including but not limited to 3D printing, but also 4D printing, 5D printing and 6D printing. It can be effectively combined with vascularization to meet the needs of vascularized tissue scaffolds by precisely tuning the mechanical structure and biological properties of smart vascular scaffolds. Herein, the development of neovascularization to vascularization to bone tissue engineering is systematically discussed in terms of the importance of vascularization to the tissue. Additionally, the research progress and future prospects of vascularized 3D printed scaffold materials are highlighted and presented in four categories: functional vascularized 3D printed scaffolds, cell-based vascularized 3D printed scaffolds, vascularized 3D printed scaffolds loaded with specific carriers and bionic vascularized 3D printed scaffolds. Finally, a brief review of vascularized additive manufacturing-tissue scaffolds in related tissues such as the vascular tissue engineering, cardiovascular system, skeletal muscle, soft tissue and a discussion of the challenges and development efforts leading to significant advances in intelligent vascularized tissue regeneration is presented.
A survey on IoT & embedded device firmware security: architecture, extraction techniques, and vulnerability analysis frameworks
Authors: Ul Haq Shahid , Singh Yashwant , Sharma Amit , Gupta Rahul , Gupta Dipak
Published: October 2023

IoT and Embedded devices grow at an exponential rate, however, without adequate security mechanisms in place. One of the key challenges in the cyber world is the security of these devices. One of the main reasons that these devices are active targets for large-scale cyber-attacks is a lack of security standards and thorough testing by manufacturers. Manufacturer-specific operating systems or firmware of various architectures and characteristics are typically included with these devices. However, due to a lack of security testing and/or late patching, the underlying firmware or operating systems are vulnerable to numerous types of vulnerabilities. Reverse engineering and in-depth research of the firmware is required to detect the vulnerabilities. In this paper, we've delved into various aspects of IoT and embedded devices. This includes a comprehensive survey on the architecture of firmware, techniques for firmware extraction, and state-of-the-art vulnerability analysis frameworks for the detection of vulnerabilities using various approaches like static, dynamic, and hybrid approaches. Furthermore, we’ve scrutinized the challenges of existing vulnerability analysis frameworks and proposed a novel framework to address these issues.