bluuebunny/crossref_metadata_2025 huggingface dataset:
Vejetaryen Sporcu Olmak; Besin Tüketimi Nasıl Şekillenmeli?
Authors: METE Zeynep , ERSOY Nesli , ERSOY Gülgün
Published: September 2022

Vejetaryen sporcu sayısı her geçen gün artış göstermekte ancak bu artışa paralel olarak sporculara referans olabilecek literatür sayısı oldukça sınırlı kalmaktadır. Vejetaryen bireyler çoğunlukla ani şekilde, sağlık kontrolü geçirmeden ve diyetisyen desteği almadan besin tüketimlerini değiştirmektedirler. Vejetaryen olmaya karar veren bir sporcunun diyetinden hayvansal besinleri çıkarması ile günlük gereksinmesi olan enerji, protein, B12 vitamini, demir, çinko, kalsiyum, iyot, D vitamini ve n-3 yağ asitleri gibi besin ögelerini yetersiz alması olasıdır. Sporcu bu besin ögelerinin bitkisel kaynaklarını diyetine eklemediği takdirde spor performansının azalmasının yanı sıra sağlık problemleri yaşama riski artmaktadır. Bu yeni beslenme düzeninin antrenman/müsabaka sürecine adapte edilmesi ise büyük önem taşımaktadır. Bunun yanı sıra vejetaryenliğin spor performansı üzerine etkisi ile ilgili kesin net sonuçlar belirtmek mümkün değildir. Ancak şuan ki veriler ile iyi planlanmış besin tüketimi ve destekleri ile spor performansının olumsuz etkilenmediğini söylemek mümkündür. Bu derleme yazıda vejetaryen sporcuların performans ve besin tüketimi üzerine yapılmış olan güncel literatür bilgisi değerlendirilmiş ve sunulmuştur. Konuya dikkat çekilmesi ve daha fazla yayın yapılmasının teşvik edilmesi büyük önem taşımaktadır.
Yaşa Bağlı Makula Dejenerasyonunda Yeni Tedavi Yaklaşımlarında Polifenoller
Authors: KURT Akif Hakan , KARA ÖZTABAĞ Cansu , KAYMAZ Abdulgani
Published: September 2022

Yaşa bağlı makula dejenerasyonu (YBMD), dünya çapında milyonlarca insanı etkileyen bir retina hastalığıdır. Gözün retina pigment epiteli (RPE) ve fotoreseptörlerinin nörodejenererasyonu sonucu görme kaybı ile karakterize multifaktöriyel bir hastalıktır. 65 yaş üstü kişilerde geri dönüşü olmayan görme bozukluğunun önde gelen sebepleri arasında yer alan, YBMD’nin prevalansı hızla artmasına karşın, oluşan görme kaybının etkin bir tedavisi yoktur. Güncel çalışmalar ile, YBMD’nin farmakoterapisi hala istenen düzeyde olmasa da antioksidan tedaviler ile hastalığın seyri yavaşlatılmaktadır. Bir çok meyve ve sebzede bulunan polifenollerin antikanser, anti-inflamatuar, antiapoptotik özelliklerinin yanı sıra antioksidan özelliğe de sahip olması YBMD’nin önlenmesi için bir umut olmuştur. Son zamanlarda, polifenollerin YBMD’nin önlenmesinde rolü olduğuna işaret eden çalışmalar yayınlanmıştır. Güçlü antioksidan özelliğe sahip polifenollerin oksidatif hasara karşı doğrudan reaktif oksijen türlerini (ROS) süpürme dışında, kronik inflamasyon ve apoptotik yolaklar üzerinden nöroprotektif etkisi olduğunu gösteren çalışmalar da bu görüşü desteklemektedir. Bu derleme yazısında polifenollerin YBMD gibi retina hastalıklarının önlenmesinde ki rolü ve etkin tedavi yaklaşımları irdelenmiştir.
Farklı Polisaj Sistemlerinin Yeni Alkasit Restoratif Materyalin Renk Değişimine Etkisinin Değerlendirilmesi
Authors: KARAKAŞ Seda Nur , KÜDEN Cihan
Published: September 2022

Amaç: Bu çalışmanın amacı, farklı sistemlerle polisajlanmış diş dolgularında kullanılan alkasitin bir renklendirici ajana maruz kalmasının ardından 24. saat ve yedinci gününde oluşan renk değişimlerinin incelenmesidir. Yöntem: 8 mm çapında ve 2 mm yüksekliğinde teflon kalıplar içerisine yerleştirilen alkasit materyali mylar strip uygulaması altında polimerize edildi ve toplam 30 adet örnek elde edildi (n=10). Materyaller rastgele 3 gruba ayrıldı; Grup 1: Elmas grenli polisaj lastikleri (Twist Dia; Kuraray, Japan), Grup 2: Alüminyum oksit diskleri (Sof-Lex; 3M ESPE, MN, USA) uygulanarak polisaj işlemi tamamlandı. Grup 3’te polisaj sistemi uygulanmadı. İlk renk ölçümü bir spektrofotometre kullanılarak gerçekleştirildi. Kahve içerisine daldırıldıktan 24. saat ve 7. gün sonra ikinci ve üçüncü renk ölçümleri aynı cihaz ile tamamlandı. CIEDE2000 renk formülü kullanılarak renk değişimleri (ΔE00) belirlendi. Bulgular tek yönlü ANOVA ve Tukey testi kullanılarak %95 güven aralığında analiz edildi. Bulgular: ΔE00 değerleri 24 saat ile 7. gün arasında alınan ölçümlerde tüm gruplar için istatistiksel olarak anlamlı bir artış gözlenmiştir. 24 saat sonunda en düşük ortalama renk değişimi değerleri Grup 2’de gözlenirken (p0,05). Kontrol grubu ise en yüksek renk değişim değerlerini göstermiştir (p
Hemşirelik Öğrencilerinin Simülasyon Eğitiminde Yaşadığı Stres, Bireyselleştirilmiş Bakım Verme Algıları ile Memnuniyet Durumlarının İncelenmesi
Authors: KÖK Gülşah , GÜVENÇ Gülten , KILIÇ UÇAR Ayşe , BEKTAŞ PARDES Burçin , ÖZER Esra , ÖZTÜRK Tuğba , ÖZKEÇECİ Fulden , ÇETİNKAYA ŞEN Yeşim
Published: September 2022

Amaç: Hemşirelik öğrencilerinin simülasyon eğitimi öncesi ve sonrası algıladıkları stres düzeyi ve bireyselleştirilmiş bakım verme algıları ile simülasyon eğitimi sonrası memnuniyet düzeylerinin belirlenmesidir.

Gereç ve Yöntemler: Yarı-deneysel çalışma yöntemi kullanılarak yapılan bu araştırmanın örneklemini bir hemşirelik fakültesinde bulunan 148 öğrenci oluşturmuştur. Simulasyon eğitim öncesi ve sonrasında verilerin toplanması amacıyla sosyodemografik veri toplama formu, Hemşirelik Öğrencileri için Algılanan Stres Ölçeği, Bireyselleştirilmiş Bakım Skalası A (BBSA)-Hemşire Versiyonu ölçeği ile Öğrenmede Öğrenci Memnuniyeti ve Özgüven Ölçeği kullanılmıştır. Simülasyon eğitimi preeklemsi-eklemsi, postpartum hemoraji, gebelikte diyabet ve aile planlaması olmak üzere 4 vaka üzerinden yürütülmüştür.

Bulgular: Simülasyon eğitimi sonrası öğrencilerin algılanan stres ölçeği puan ortalaması (60,88±31,07) eğitim öncesine göre düşük, eğitim sonrası BBSA-Hemşire Versiyonu puan ortalaması (4,43±0,68) ise yüksek bulunmuştur. Eğitim öncesi dönemde mesleği sevdiğini belirten öğrencilerin stres puan ortalamaları (69,00±28,46) düşük, BBSA-Hemşire Versiyonu puan ortalaması (4,33±0,64) yüksektir. Mesleği isteyerek tercih eden öğrencilerin eğitim öncesi BBSA-Hemşire Versiyonu puan ortalaması (4,30±0,86) diğer öğrencilerle karşılaştırıldığında yüksektir. Öğrencilerin simülasyon eğitimi sonrası Öğrenmede Öğrenci Memnuniyeti Ölçeği Puan Ortalamaları 22,21±3,01 olarak bulunmuştur.

Sonuç: Gerçek hasta ile karşılaştıklarında olumlu deneyim yaşamalarını sağlayabilmek amacıyla verilen simülasyon eğitiminin öğrencilerin algıladıkları stres düzeyini azalttığı ve bireyselleştirilmiş bakım verme becerilerini arttırdığı görülmektedir. Aynı zamanda öğrencilere verilen simülasyon eğitimi ile öğrenciler üzerinde öğrenmede memnuniyet oluşturmaktadır.
COVID-19 Pandemisinin Üniversite Öğrencilerinin Ruh Sağlığına Etkisi Üzerine Bir Değerlendirme
Authors: DİKİCİ Arzu
Published: September 2022

Yaklaşık iki yıldır dünyayı etkisi altına alan COVID-19 pandemisi tarihte benzeri görülmemiş küresel etkilere neden olmaktadır. COVID-19 pandemi süreci Dünya’da “yeni normal” kavramını gündeme getirmiş ve hayatın her alanında radikal değişikliklere yol açmıştır. Yeni normal kavramı ile birlikte dünya genelinde, sosyal, ekonomik, siyasal ve sağlık alanında önlemler alınmıştır. Enfeksiyon yayılımını önlemek için pandeminin başladığı ilk günlerden itibaren zorunlu karantina, kısıtlama, fiziksel mesafe kuralları, sosyal izolasyon gibi önlemler hayatın içine dahil olmuştur. Bu önlemler arasında yüz yüze eğitimin sonlandırılması ve hızlıca uzaktan eğitim sistemine geçiş yer almaktadır. Eğitim sistemindeki bu hızlı dönüşüm hem eğitimcilerin hem de öğrencilerin kısa sürede pandemi sürecinin getirdiği yeni yaşam durumlarına uyum sağlamalarını ve sisteme dâhil olmalarını gerektirmiştir. Bu dönüşümün, üniversite öğrencilerini ruhsal açıdan etkilemesi kaçınılmazdır. Bu önlemlerin süresinin uzaması, belirsizlik ve özgürlüklerin sınırlandırılması, öğrencilerde anksiyete, depresif duygu durum, dikkat ve odaklanmada güçlük, stres ve anksiyeteye bağlı uyku ve yeme bozuklukları gibi ruhsal belirtilerin ortaya çıkmasına neden olmaktadır. Derleme niteliğindeki bu makalede, pandeminin ruhsal etkilerinin, kırılgan bir grup olan üniversite öğrencilerinin ruhsal açıdan etkilenme durumlarına ilişkin güncel bilgilerin ortaya konması ve olası çözüm önerilerinin mevcut literatür bilgisi ışığında irdelenmesi amaçlanmıştır.
Strategies and Models for Development of Hot Water Tourism Objects in Tombasian Village Under Kawangkoan Barat District, Minahasa Regency
Authors: Telly H.I Kondoj  , Vesti L.Sambeka
Published: September 2022

Tourism development is sought to be developed in the context of economic improvement, sustainable development and technological development. Geographically, each region has different characteristics with their own uniqueness and advantages. Natural resources that are owned with all its contents, land in all its forms and the sea with all its contents. This potential can be utilized optimally through tourism. Natural resources owned with all their contents and existing potential will be utilized for development purposes. That potential can be an asset through the tourism sector. One of the attractions that attracts the attention of both domestic and foreign tourists is the hot springs in Tombasian Bawah Village. Tombasian Bawah Village is one of the villages in Kawangkoan Barat District, Minahasa Regency, where in general the people work as farmers and craftsmen on stilt houses. Furthermore, the data that has been collected is analyzed by descriptive analysis using the SWOT analysis method and breaking it down internally and externally. The stages of the research were field observations by collecting data at the physical location, conducting interviews with the government of tourist attraction locations with village programs and district governments related to the development of tourism objects, specifically hot water in the village of Tombasian Bawah and visitors to obtain data. The results of the study show that the Hot Spring Tourism Object Development Strategy is adequate which can be applied by developing tourism on holidays and other holidays. And the model is community based. The development of this hot spring tourism object can be done by diversifying tourism objects and modifying the system so that tourists can travel easily and pleasantly. The results of this research are the proceding/Sentrinov output targets and reports.
The Development of International Tourists During The Pandemic: The Perception of Local Tourists
Authors: Ratu Noorita Achmad  , Muhammad Arifin Muhammad Salim  , Amirullah
Published: September 2022

The Covid-19 pandemic has hampered various kinds of activities, especially in the world of tourism. Based on data on international tourist visits to Indonesia in August, it experienced a significant decrease of 89.22%. The Deputy for Destination and Infrastructure Development of the Ministry of Tourism and Creative Economy (Kemenparekraf) predicts that international tourist visits to Indonesia only occupy the number 4 million people, which before the pandemic occupied the figure of 18 million visitors. The purpose of this study is to find out the perception of local tourists towards the development of international tourists during the pandemic, the method used is to conduct interviews with local tourists randomly in the Barru district. The analysis method used is descriptive qualitative to explain the research results obtained. The result of this study is that the decline in tourism visitors has a significant impact on people's income, especially in Barru district, but this, it can reduce the spread of the Covid-19 virus that is sweeping the world.
ESSENSI MAZHAB SEJARAH DALAM PERKEMBANGAN FILSAFAT HUKUM
Authors: Darmawan Iwan , Nugraha Roby Satya , Sukmana Sobar
Published: September 2022

AbstrakMazhab sejarah merupakan mazhab dalam filsafat hukum yang sangat penting dalam perkembangan filsafat hukum. Konsepsinya yang mengedepankan jiwa bangsa (volkgeis), dengan ungkapan yang dikemukakan Von Savigny “das recht wird nicht gemacht, est ist und wird mit dem volke”, yang mengandung arti “hukum itu tidak dibuat, tetapi tumbuh dan berkembang bersama masyarakat”. Konsepsi ini sangat berpengaruh bagi perumusan konsep hukum tidak hanya di Jerman, tetapi sudah meluas ke luar Jerman termasuk Indonesia.  Kelebihan konsepsi mazhab sejarah ini mampu memandang bahwa hukum-hukum yang berasal dari masa lalu merupakan hukum yang pernah dijalankan di masa lalu, dan sedikit banyak akan mempengaruhi hukum yang berlaku di masa sekarang, karena jiwa bangsa (volkgeist), sesuai dengan jiwa masyarakatnya yang merupakan sumber dari segala hukum yang tumbuh dan berkembang dalam masyarakat tersebut dari waktu ke waktu dan dari masa ke masa. Filsuf-filsuf yang lahir dan menjadi pelopor bagi mazhab sejarah ini mendasarkan pemikirannya bahwa hukum terbentuk di luar legislasi, artinya hukum tidak dibuat oleh lembaga formal, tetapi tumbuh dan berkembang di masyarakat secara alami.  Kata kunci : Mazhab Sejarah, Jiwa Bangsa (Volkgeist), Filsafat Hukum. AbstrakThe historical school is a school in legal philosophy which is very important in the development of legal philosophy. The concept is the soul of the nation (volkgeis), with the phrase put forward by Von Savigny "das recht wird nicht gemacht, est ist und wird mit dem volke", which means "law is not made, but grows and develops with the community". This conception is very influential for the formulation of legal concepts not only in Germany, but also outside Germany, including Indonesia. The advantage of this historical school of thought is that it is able to view that laws originating from the past are laws that have been implemented in the past, and will more or less affect the laws that apply in the present, because the spirit of the nation (volkgeist), is in accordance with the soul of the people who are the source of all laws that grow and develop in the community from time to time and from time to time. Philosophers who were born and became pioneers for this school of history based their thinking that law is formed outside of legislation, meaning that law is not made by formal institutions, but grows and develops in society naturally. Keywords : School of History, Soul of the Nation (Volkgeist), Philosophy of Law.
Characteristics of culture-condition stimulated exosomes or their loaded hydrogels in comparison with other extracellular vesicles or MSC lysates
Authors: Luo Yu , Li Zhihua , Wang Xinxin , Wang Juan , Duan Xingxiang , Li Ruohan , Peng Youjian , Ye Qingsong , He Yan
Published: September 2022

Recently, it has become popular to study the use of extracellular vesicles (EVs) secreted by stem cells to repair damaged tissues or lost cells. Various cell types and physiological fluids release EVs, and they play an important role in cell-to-cell communication. Moreover, EVs have been implicated in important processes, such as immune responses, homeostasis maintenance, coagulation, inflammation, cancer progression, angiogenesis, and antigen presentation. Thus, EVs participate in both physiological and pathological progression. The main classes of EVs include exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). Exosomes, which carry a mass of signal molecules such as RNA, DNA, proteins, and lipids, are the most important of these EVs subsets. Currently, exosomes are generating substantial interest in the scientific community. Exosomes loaded hydrogels or under different cultural environments exhibit different properties and functions. Therefore, the exosomes obtained from different sources and conditions are worth reviewing. More importantly, no review article has compared the different EVs, such as exosomes, MVs, ApoBDs, and mesenchymal stem cell (MSC) lysates, which are special soluble substances. The differentiation between EVs and MSC lysates is a logical approach. Accordingly, this review provides an update on the latest progress in studying the roles of culture-condition stimulated exosomes or their loaded hydrogels and the differentiation between exosomes, MVs, ApoBDs, and MSC lysates. Published studies were retrieved from the PubMed® database for review.
UPRmt and coordinated UPRER in type 2 diabetes
Authors: Kang Zhanfang , Chen Feng , Wu Wanhui , Liu Rui , Chen Tianda , Xu Fang
Published: September 2022

The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D). Similarly, the unfolded protein response of the endoplasmic reticulum (UPRER) is responsible for maintaining proteomic stability in the endoplasmic reticulum (ER). Since the mitochondria and endoplasmic reticulum are the primary centers of energy metabolism and protein synthesis in cells, respectively, a synergistic mechanism must exist between UPRmt and UPRER to cooperatively resist stresses such as hyperglycemia in T2D. Increasing evidence suggests that the protein kinase RNA (PKR)-like endoplasmic reticulum kinase (PERK) signaling pathway is likely an important node for coordinating UPRmt and UPRER. The PERK pathway is activated in both UPRmt and UPRER, and its downstream molecules perform important functions. In this review, we discuss the mechanisms of UPRmt, UPRER and their crosstalk in T2D.
RNA-binding protein signaling in adult neurogenesis
Authors: Chan Jackie Ngai-Man , Sánchez-Vidaña Dalinda Isabel , Anoopkumar-Dukie Shailendra , Li Yue , Benson Wui-Man Lau
Published: September 2022

The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in certain brain regions during adulthood. In adult neurogenesis, the production of new neurons in the hippocampus is accomplished via the division of neural stem cells. Neurogenesis is regulated by multiple factors, including gene expression at a temporal scale and post-transcriptional modifications. RNA-binding Proteins (RBPs) are known as proteins that bind to either double- or single-stranded RNA in cells and form ribonucleoprotein complexes. The involvement of RBPs in neurogenesis is crucial for modulating gene expression changes and posttranscriptional processes. Since neurogenesis affects learning and memory, RBPs are closely associated with cognitive functions and emotions. However, the pathways of each RBP in adult neurogenesis remain elusive and not clear. In this review, we specifically summarize the involvement of several RBPs in adult neurogenesis, including CPEB3, FXR2, FMRP, HuR, HuD, Lin28, Msi1, Sam68, Stau1, Smaug2, and SOX2. To understand the role of these RBPs in neurogenesis, including cell proliferation, differentiation, survival, and maturation as well as posttranscriptional gene expression, we discussed the protein family, structure, expression, functional domain, and region of action. Therefore, this narrative review aims to provide a comprehensive overview of the RBPs, their function, and their role in the process of adult neurogenesis as well as to identify possible research directions on RBPs and neurogenesis.
Metagenomic next-generation sequencing may assist diagnosis of cat-scratch disease
Authors: Li Mingxia , Yan Kunli , Jia Peisheng , Wei Erhu , Wang Huaili
Published: September 2022

Bartonella henselae, the pathogen that causes cat-scratch disease (CSD), is relatively rare in the clinic. CSD usually causes mild clinical manifestations, which self-heal in a matter of weeks. However, in immunocompromised patients, CSD may cause systemic disorders that can lead to critical illness. Due to the diversity of symptom signs and the lack of a golden standard for diagnosis, identifying atypical CSD in a timely manner presents a challenge. Metagenomic next-generation sequencing (mNGS), is a promising technology that has been widely used in the detection of pathogens in clinical infectious diseases in recent years. mNGS can detect multiple pathogens quickly and accurately from any given source. Here, we present a case of atypical CSD, which was diagnosed using mNGS. The patient manifested a fever of unknown infectious origin, and routine antibiotic treatment was ineffective. mNGS was employed to test the patient’s peripheral blood, which led to the detection of B. henselae. This was rarely seen in previous CSD reports. We surmised that the patient presented with atypical CSD and thus a targeted therapy was recommended. Crucially, the patient recovered rapidly. Based on this case study findings, we recommend that CSD should be included in the differential diagnosis for fever of unknown origin and that mNGS may be helpful in the diagnosis of CSD.
IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice
Authors: Liu Menglin , Wang Zhen , Zhang Jishou , Ye Di , Wang Menglong , Xu Yao , Zhao Mengmeng , Feng Yongqi , Lu Xiyi , Pan Heng , Pan Wei , Wei Cheng , Tian Dan , Li Wenqiang , Lyu Jingjun , Ye Jing , Wan Jun
Published: September 2022

Background

Cardiac dysfunction is one of the most common complications of sepsis and is associated with the adverse outcomes and high mortality of sepsis patients. IL-12p40, the common subunit of IL-12 and IL-23, has been shown to be involved in a variety of inflammation-related diseases, such as psoriasis and inflammatory bowel disease. However, the role of IL-12p40 in lipopolysaccharide (LPS)-induced cardiac dysfunction remains obscure. This study aimed to explore the role of IL-12p40 in LPS-induced cardiac dysfunction and its potential mechanisms.

Methods

In this study, mice were treated with LPS and the cardiac expression of IL-12p40 was determined. Then, IL-12p40–/– mice were used to detect the role and mechanisms of IL-12p40 in LPS-induced cardiac injury. In addition, monocytes were adoptively transferred to IL-12p40–/– mice to explore their effects on LPS-induced cardiac dysfunction.

Results

The results showed that cardiac IL-12p40 expression was significantly increased after treated with LPS. In addition, IL-12p40 deletion significantly aggravated LPS-induced cardiac dysfunction, evidenced by the increased serum levels of cardiomyocyte injury markers and heart injury scores, as well as by the deteriorated cardiac function. Moreover, IL-12p40 deletion increased LPS-induced monocyte accumulation and cardiac expression of inflammatory cytokines, as well as enhanced the activation of the NF-κB and MAPK pathways. Furthermore, adoptive transfer WT mouse monocytes to IL-12p40−/− mice alleviated LPS-induced cardiac dysfunction and decreased the phosphorylation of p65.

Conclusion

IL-12p40 deletion significantly aggravated LPS-induced cardiac injury and cardiac dysfunction in mice by regulating the NF-κB and MAPK signaling pathways, and this process was related to monocytes. Therefore, IL-12p40 show a protective role in SIC, and IL-12p40 deficiency or anti-IL-12p40 monoclonal antibodies may be detrimental to patients with SIC.
Immediate reduction in left ventricular ejection time following TAVI is associated with improved quality of life
Authors: Schenk Jimmy , Kho Eline , Rellum Santino , Kromhout Joris , Vlaar Alexander P. J. , Baan Jan , van Mourik Martijn S. , Jorstad Harald T. , van der Ster Björn J. P. , Westerhof Berend E. , Bruns Steffen , Immink Rogier V. , Vis Marije M. , Veelo Denise P.
Published: September 2022

Background

TAVI has shown to result in immediate and sustained hemodynamic alterations and improvement in health-related quality of life (HRQoL), but previous studies have been suboptimal to predict who might benefit from TAVI. The relationship between immediate hemodynamic changes and outcome has not been studied before. This study sought to assess whether an immediate hemodynamic change, reflecting myocardial contractile reserve, following TAVI is associated with improved HRQoL. Furthermore, it assessed whether pre-procedural cardiac power index (CPI) and left ventricular ejection fraction (LVEF) could predict these changes.

Methods

During the TAVI procedure, blood pressure and systemic hemodynamics were prospectively collected with a Nexfin® non-invasive monitor. HRQoL was evaluated pre-procedurally and 12 weeks after the procedure, using the EQ-5D-5L classification tool.

Results

Overall, 97/114 (85%) of the included patients were eligible for analyses. Systolic, diastolic and mean arterial pressure, heart rate, and stroke volume increased immediately after TAVI (all p < 0.005), and left ventricular ejection time (LVET) immediately decreased with 10 ms (95%CI = −4 to −16, p < 0.001). Overall HRQoLindex increased from 0.810 [0.662–0.914] before to 0.887 [0.718–0.953] after TAVI (p = 0.016). An immediate decrease in LVET was associated with an increase in HRQoLindex (0.02 index points per 10 ms LVET decrease, p = 0.041). Pre-procedural CPI and LVEF did not predict hemodynamic changes or change in HRQoL.

Conclusion

TAVI resulted in an immediate hemodynamic response and increase in HRQoL. Immediate reduction in LVET, suggesting unloading of the ventricle, was associated with an increase in HRQoL, but neither pre-procedural CPI nor LVEF predicted these changes.

Clinical trial registration

https://clinicaltrials.gov/ct2/show/NCT03088787
The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism
Authors: Yu Bingqing , Chen Kepu , Mao Jiangfeng , Hou Bo , You Hui , Wang Xi , Nie Min , Huang Qibin , Zhang Rui , Zhu Yiyi , Sun Bang , Feng Feng , Zhou Wen , Wu Xueyan
Published: September 2022

Objective

The aim of this study was to evaluate the diagnostic accuracy of different olfactory evaluation tools in congenital hypogonadotropic hypogonadism (CHH) patients.

Methods

Seventy-one CHH patients were prospectively recruited at Peking Union Medical College Hospital between November 2020 and July 2021. The Chinese Olfactory Function Test (COFT) and Self-reported Olfactory Scale (SROS) were adapted as the subjective tools for the evaluation of olfactory function, and magnetic resonance imaging of olfactory apparatus (MRI-OA) was the objective tool. The olfactory bulb volume (OBV) and the olfactory sulcus depth (OSD) were quantified.

Results

Based on the COFT, 36 patients were categorized as having normosmic CHH (nCHH), and the other 35 patients were categorized as having Kallmann syndrome (KS). Among nCHH patients, 35 patients were classified as having normal olfaction and 1 patient had abnormal olfaction by SROS. For KS patients, there were 30 patients grouped into abnormal olfaction, while 5 patients had normal olfaction by SROS. For MRI-OA, 67% (18/27) of nCHH patients showed normal olfactory apparatus, and 33% (9/27) showed bilateral or unilateral olfactory bulb aplasia or hypoplasia. Among KS patients, 96% (27/28) of patients showed bilateral olfactory bulb hypoplasia or aplasia, and 4% (1/28) of patients showed normal olfactory apparatus. All six patients with unilateral olfactory bulb aplasia and three patients with bilateral olfactory bulb aplasia showed normal olfactory function. The accuracy of the SROS in the diagnosis of nCHH and KS was 91.5%, with a sensitivity of 0.857 and a specificity of 0.972, while the accuracy of MRI-OA is 92.7%, with a sensitivity of 0.964 and a specificity of 0.889.

Conclusion

SROS and MRI-OA both showed high accuracy to distinguish between KS and nCHH. The abnormal structure of the olfactory apparatus was relatively common in nCHH patients. CHH patients with unilateral olfactory bulb aplasia dysplasia usually had normal olfaction. Normal olfaction without apparent olfactory bulbs is rare but occurred in male CHH patients.
Recent developments of proton exchange membranes for PEMFC: A review
Authors: Parekh Abhi
Published: September 2022

The decreasing abundance of conventional energy resources of nature, such as crude oil, natural gas, and coal, is putting forward the issues of energy shortcoming for the future. With a sentiment of this, most researchers are now directing either on non-conventional resources that already prevail or invent it. The most promising non-conventional energy resource is the hydrogen energy, which can be used in fuel cell to get electricity. Therefore, a number of researchers are putting a light on developing the most efficient and affordable fuel cell. This review is mainly focused on the developments of proton exchange membranes (PEMs) in two parts as low and high temperature PEMs for proton exchange membrane fuel cell (PEMFC) and based on that some outperformed PEMs are mentioned in the respective tables. Most of the energy and automobile industries are concentrating to apply PEMFCs for power generation and to apply in vehicles. The cost of PEMFCs is higher due to the manufacturing cost of PEM. Therefore, research works in PEMs are now in trend to reduce the cost, to improve efficiency, and to withstand particular operating conditions. In this review article, recent developments in PEM by number of researchers and the importance of it in near future have been elicited.
A review of battery energy storage systems for ancillary services in distribution grids: Current status, challenges and future directions
Authors: Prakash Krishneel , Ali Muhammad , Siddique Md Nazrul Islam , Chand Aneesh A. , Kumar Nallapaneni Manoj , Dong Daoyi , Pota Hemanshu R.
Published: September 2022

Battery Energy Storage Systems (BESS) are essential for increasing distribution network performance. Appropriate location, size, and operation of BESS can improve overall network performance. The appropriately scaled and installed BESS helps meet peak energy demand, improve the advantages of integrating renewable and distributed energy sources, improve power quality control, and lower the cost of expanding or re-configuring the distribution networks. This paper investigates the feasibility of BESS for providing short-term and long-term ancillary services in power distribution grids by reviewing the developments and limitations in the last decade (2010–2022). The short-term ancillary services are reviewed for voltage support, frequency regulation, and black start. The long-term ancillary services are reviewed for peak shaving, congestion relief, and power smoothing. Reviewing short-term ancillary services provides renewable energy operators and researchers with a vast range of recent BESS-based methodologies for fast response services to distribution grids. Long-term ancillary services will provide the distributed network system operators and researchers with current BESS-based bulk-energy methods to improve network reliability and power quality and maximize revenue from renewable energy generation. The review presents a list of energy storage policies and BESS projects worldwide with a cost-benefit analysis. The challenges for deploying BESS in distribution grids recommended solutions for the implementation challenges, and future research directions are also presented.
RETRACTED: The Nexus between sustainability of business model innovation, financial knowledge, and environment: A developing economy perspective
Authors: Yun Xiaopeng , Zhang Jie , Ali Anis , Khurram Haris
Published: September 2022

This study intends to investigate how aspects such as financial knowledge and the rate of technological advancement influence the lifetime of enterprises in developing nations like Pakistan. For this purpose, a survey study was designed to obtain data from 325 business owners in different parts of the country. Structural Equation Modelling (SEM) was utilized to analyze this dataset. According to the analysis outcomes, not only do practices connected to financial literacy and innovation play a crucial role in a firm’s long-term viability, but they also have a substantial beneficial impact on the company’s viability. The research concluded that an increase in financial knowledge, expertise, and experience in corporate operations helps the continued viability of firms. Knowledge of financial concerns also predicted the company’s ability to innovate and adapt. In addition to the environmental sustainability of the business. As a result, it was concluded that it plays the role of a mediator in the link between innovation and the ongoing existence of businesses. Because of this, financial literacy is now acknowledged as a vital knowledge resource for determining one’s financial course of action, which was not the case previously. According to the study’s conclusions, for businesses to continue to be sustainable, authorities need to enhance their financial literacy level and adopt sustainability models into their day-to-day operations.
Spatial–Temporal pattern and evolutionary trend of eco-efficiency of real estate development in the yangtze river economic belt
Authors: Fan Zhenggen , Deng Zhikang , Qi Yawei , Pan JiaSen
Published: September 2022

The eco-efficiency of real estate development (RED) is an important indicator in evaluating the effectiveness of eco-civilization construction. Thus, analyzing its temporal evolution and spatial spillover effect can help to judge the degree of coordinated development between RED and eco-civilization construction in the Yangtze River Economic Belt (YREB). From an ecology-based angle of RED, the data of 108 cities in YREB from 2006 to 2020 were selected. Then, the Super-SBM model, Moran’s I model, and Markov chain model were used to measure the eco-efficiency value of RED and analyze its spatial–temporal evolutionary characteristics. Research results indicate that the eco-efficiency of RED in YREB increased by 7.3%. Differences were apparent in the regional eco-efficiency of RED, but the gap gradually narrowed, and the range decreased from 0.60 to 0.05. A positive spatial autocorrelation was observed in the eco-efficiency of RED, and the high–high (H-H) cluster areas showed a trend of expansion and transfer. The proportion of H-H cluster cities increased from 11 to 20%, whereas the low–low cluster areas showed a trend of small-scale diffusion. The eco-efficiency of RED exhibited consistently stable and “club convergence” characteristics. When the spatial spillover effect is ignored, the eco-efficiency of RED presents at least 55.1% probability to be maintained in the original state. By contrast, when the spatial spillover effect is considered, the probability can be increased, and the assimilation effect of transferring the eco-efficiency of RED can be enhanced. In the future, the overall eco-efficiency of RED in YREB can be improved by exploring new development technologies, establishing collaborative development mechanisms among cities, and adopting eco-protection-oriented reward and punishment policies.
Can we have our steak and eat it: The impact of breeding for lowered environmental impact on yield and meat quality in sheep
Authors: Rowe S. J. , Hickey S. M. , Bain W. E. , Greer G. J. , Johnson P. L. , Elmes S. , Pinares-Patiño C. S. , Young E. A. , Dodds K. G. , Knowler K. , Pickering N. K. , Jonker A. , McEwan J. C.
Published: September 2022

Global agreements in place to reduce methane emissions in livestock are a potential threat to food security. Successful but independent breeding strategies for improved production and lower methane are in place. The unanswered questions are whether these strategies can be combined and how they impact one another, physically and economically. The New Zealand economy is largely dependent on pastoral agriculture from grazing ruminants. The sheep industry produces ∼20 million lamb carcasses for export each year primarily from grass. Methane emitted from the fermentation of forage by grazing ruminants accounts for one-third of all New Zealand’s greenhouse gas emissions. Here, we use sheep selection lines bred for divergent methane production and large numbers of their relatives to determine the genetic and phenotypic correlations between enteric methane emissions, carcass yield, and meat quality. The primary objectives were to determine whether previously shown physiological differences between methane selection lines (differing by ∼12% in methane) result in a negative impact on meat production and quality by measuring close relatives. The results show no negative effects of breeding for lowered methane on meat and carcass quality. Gross methane emissions were highly correlated with liveweight and measures of carcass weight and negatively correlated with dressing-out percentage and fat yield (GR). Trends were similar but not significant for methane yield (g CH4/kg DMI). Preliminary evidence, to date, shows that breeding for low methane may result in animals with higher lean yields that are economically favorable even before carbon costs and environmental benefits are taken into account. These benefits were seen in animals measured for methane on fixed intakes and require validation on intakes that are allowed to vary.
GBP2 as a potential prognostic predictor with immune-related characteristics in glioma
Authors: Li Ren , Wang Yuan-Yuan , Wang Shu-Le , Li Xue-Peng , Chen Yang , Li Zi-Ao , He Jian-Hang , Zhou Zi-Han , Li Jia-Yu , Guo Xiao-Long , Wang Xiao-Gang , Wu Yong-Qiang , Ren Ye-Qing , Zhang Wen-Ju , Wang Xiao-Man , Guo Geng
Published: September 2022

Guanylate binding protein 2 (GBP2) is a member of the guanine binding protein family, and its relationship with prognostic outcomes and tumor immune microenvironments in glioma remains elusive. We found GBP2 were increased in glioma tissues at both mRNA and protein levels. Kaplan-Meier curves revealed that high GBP2 expression was linked with worse survival of glioma patients, and multivariate Cox regression analysis indicated that high GBP2 expression was an independent prognostic factor for glioma. Combined analysis in immune database revealed that the expression of GBP2 was significantly related to the level of immune infiltration and immunomodulators. Single-cell analysis illustrated the high expression of GBP2 in malignant glioma cells showed the high antigen presentation capability, which were confirmed by real-time polymerase chain reaction (qRT-PCR) data. Additionally, the hsa-mir-26b-5p and hsa-mir-335-5p were predicted as GBP2 regulators and were validated in U87 and U251 cells. Our results first decipher immune-related characteristics and noncoding regulators of GBP2 in glioma, which may provide insights into associated immunotherapies and prognostic predictor.
Development of de-novo transcriptome assembly and SSRs in allohexaploid Brassica with functional annotations and identification of heat-shock proteins for thermotolerance
Authors: Singh Kaushal Pratap , Kumari Preetesh , Yadava Devendra Kumar
Published: September 2022

Crop Brassicas contain monogenomic and digenomic species, with no evidence of a trigenomic Brassica in nature. Through somatic fusion (Sinapis alba+B. juncea), a novel allohexaploid trigenomic Brassica (H1 = AABBSS; 2n= 60) was produced and used for transcriptome analysis to uncover genes for thermotolerance, annotations, and microsatellite markers for future molecular breeding. Illumina Novaseq 6000 generated a total of 76,055,546 paired-end raw reads, which were used forde-novoassembly, resulting in the development of 486,066 transcripts. A total of 133,167 coding sequences (CDSs) were predicted from transcripts with a mean length of 507.12 bp and 46.15% GC content. The BLASTX search of CDSs against public protein databases showed a maximum of 126,131 (94.72%) and a minimum of 29,810 (22.39%) positive hits. Furthermore, 953,773 gene ontology (GO) terms were found in 77,613 (58.28%) CDSs, which were divided into biological processes (49.06%), cellular components (31.67%), and molecular functions (19.27%). CDSs were assigned to 144 pathways by a pathway study using the KEGG database and 1,551 pathways by a similar analysis using the Reactome database. Further investigation led to the discovery of genes encoding over 2,000 heat shock proteins (HSPs). The discovery of a large number of HSPs in allohexaploid Brassica validated our earlier findings for heat tolerance at seed maturity. A total of 15,736 SSRs have been found in 13,595 CDSs, with an average of one SSR per 4.29 kb length and an SSR frequency of 11.82%. The first transcriptome assembly of a meiotically stable allohexaploid Brassica has been given in this article, along with functional annotations and the presence of SSRs, which could aid future genetic and genomic studies.
Unraveling the viral dark matter through viral metagenomics
Authors: Santiago-Rodriguez Tasha M. , Hollister Emily B.
Published: September 2022

Viruses are part of the microbiome and have essential roles in immunology, evolution, biogeochemical cycles, health, and disease progression. Viruses influence a wide variety of systems and processes, and the continued discovery of novel viruses is anticipated to reveal new mechanisms influencing the biology of diverse environments. While the identity and roles of viruses continue to be discovered and understood through viral metagenomics, most of the sequences in virome datasets cannot be attributed to known viruses or may be only distantly related to species already described in public sequence databases, at best. Such viruses are known as the viral dark matter. Ongoing discoveries from the viral dark matter have provided insights into novel viruses from a variety of environments, as well as their potential in immunological processes, virus evolution, health, disease, therapeutics, and surveillance. Increased understanding of the viral dark matter will continue with a combination of cultivation, microscopy, sequencing, and bioinformatic efforts, which are discussed in the present review.
Adenosine signaling: Optimal target for gastric cancer immunotherapy
Authors: Wang Junqing , Du Linyong , Chen Xiangjian
Published: September 2022

Gastric cancer (GC) is one of the most common malignancy and leading cause of cancer-related deaths worldwide. Due to asymptomatic or only nonspecific early symptoms, GC patients are usually in the advanced stage at first diagnosis and miss the best opportunity of treatment. Immunotherapies, especially immune checkpoint inhibitors (ICIs), have dramatically changed the landscape of available treatment options for advanced-stage cancer patients. However, with regards to existing ICIs, the clinical benefit of monotherapy for advanced gastric cancer (AGC) is quite limited. Therefore, it is urgent to explore an optimal target for the treatment of GC. In this review, we summarize the expression profiles and prognostic value of 20 common immune checkpoint-related genes in GC from Gene Expression Profiling Interactive Analysis (GEPIA) database, and then find that the adenosinergic pathway plays an indispensable role in the occurrence and development of GC. Moreover, we discuss the pathophysiological function of adenosinergic pathway in cancers. The accumulation of extracellular adenosine inhibits the normal function of immune effector cells and facilitate the effect of immunosuppressive cells to foster GC cells proliferation and migration. Finally, we provide insights into potential clinical application of adenosinergic-targeting therapies for GC patients.
A risk signature based on necroptotic-process-related genes predicts prognosis and immune therapy response in kidney cell carcinoma
Authors: Li Jingxian , Liu Xun , Qi Yuanjiong , Liu Yang , Du E. , Zhang Zhihong
Published: September 2022

Necroptosis is a regulated form of cell necroptotic process, playing a pivotal role in tumors. In renal cell cancer (RCC), inhibiting necroptosis could promote the proliferation of tumor cells. However, the molecular mechanisms and prognosis prediction of necroptotic-process-related genes in RCC are still unclear. In this study, we first identified the necroptotic process prognosis-related genes (NPRGss) by analyzing the kidney renal clear cell carcinoma (KIRC) data in The Cancer Genome Atlas (TCGA, n=607). We systematically analyzed the expression alteration, clinical relevance, and molecular mechanisms of NPRGss in renal clear cell carcinoma. We constructed an NPRGs risk signature utilizing the least absolute shrinkage and selection operator (LASSO) Cox regression analysis on the basis of the expression of seven NPRGss. We discovered that the overall survival (OS) of KIRC patients differed significantly in high- or low-NPRGs-risk groups. The univariate/multivariate Cox regression revealed that the NPRGs risk signature was an independent prognosis factor in RCC. The gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were used to explore the molecular mechanisms of NPRGss. Immune-/metabolism-related pathways showed differential enrichment in high-/low-NPRGs-risk groups. The E-MTAB-1980, TCGA-KIRP, GSE78220, the cohort of Alexandra et al., and IMvigor210 cohort datasets were respectively used as independent validation cohorts of NPRGs risk signature. The patients in high- or low-NPRGs-risk groups showed different drug sensitivity, immune checkpoint expression, and immune therapy response. Finally, we established a nomogram based on the NPRGs risk signature, stage, grade, and age for eventual clinical translation; the nomogram possesses an accurate and stable prediction effect. The signature could predict patients’ prognosis and therapy response, which provides the foundation for further clinical therapeutic strategies for RCC patients.
Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage
Authors: Zhou Zilan , Wang Ruiping , Wang Jie , Hao Yujia , Xie Qingpeng , Wang Lu , Wang Xing
Published: September 2022

The therapeutic outcomes of exosome-based therapies have greatly exceeded initial expectations in many clinically intractable diseases due to the safety, low toxicity, and immunogenicity of exosomes, but the production of the exosomes is a bottleneck for wide use. To increase the yield of the exosomes, various solutions have been tried, such as hypoxia, extracellular acidic pH, etc. With a limited number of cells or exosomes, an alternative approach has been developed to improve the efficacy of exosomes through cell pretreatment recently. Melatonin is synthesized from tryptophan and secreted in the pineal gland, presenting a protective effect in pathological conditions. As a new pretreatment method, melatonin can effectively enhance the antioxidant, anti-inflammatory, and anti-apoptotic function of exosomes in chronic kidney disease, diabetic wound healing, and ischemia-reperfusion treatments. However, the current use of melatonin pretreatment varies widely. Here, we discuss the effects of melatonin pretreatment on the heterogeneity of exosomes based on the role of melatonin and further speculate on the possible mechanisms. Finally, the therapeutic use of exosomes and the usage of melatonin pretreatment are described.