bluuebunny/crossref_metadata_2025 huggingface dataset:
Multibiomarker responses to polycyclic aromatic hydrocarbons and microplastics in thumbprint emperor Lethrinus harak from a South Pacific locally managed marine area
Authors: Varea Rufino , Paris Andrew , Ferreira Marta , Piovano Susanna
Published: September 2021

To determine the baseline threat of microplastics and polycyclic aromatic hydrocarbons (PAHs) in an important seafood fish from Vueti Navakavu locally managed marine area, a multibiomarker risk assessment was conducted on the thumbprint emperor fish Lethrinus harak. Condition factor, a measure of relative general health condition of fish, was significantly lower in samples from the wet season compared to the dry season but no significant differences were observed for hepatosomatic index, a measure of relative stored energy/nutrition, between seasonal groups. PAHs levels of four metabolites in emperor fish from Fiji waters are reported here for the first time; seasonal groups showed no significant differences, but all samples presented levels of biliary PAHs. Each specimen also contained at least one microplastic in its gastrointestinal system; fibres were the predominant form-type and ingestion levels showed that more than 80% of fragment sizes were below 1.0 mm. Biochemical responses were observed for ethoxyresorufin-O-deethylase and glutathioneS-transferase biotransformation activity, oxidative stress (glutathione peroxidase and glutathione reductase activity; lipid peroxidation) and genotoxicity (micronuclei assay). Though there were no statistically significant differences found, there were biological significances that were important to note; relatively low levels of pollutant exposure and low levels of biochemical responses showed enzymes response in thumbprint emperor were as expected to their roles in the body. In this multibiomarker approach, the observation of pollutants presence and histopathological injuries are considered biologically relevant from a toxicological perspective and serve as a baseline for future pollution studies in seafood fishes in Fiji, with site differences and the inclusion of fish species comparison. We recommend adopting a suite of biomarkers in future regional biomonitoring studies to develop holistic baseline information for other marine settings in Fiji and other Pacific Island countries.
Socioeconomic inequalities in treatment and relative survival among patients with diffuse large B-cell lymphoma: a Hong Kong population-based study
Authors: Lee Shing Fung , Evens Andrew M. , Ng Andrea K. , Luque-Fernandez Miguel-Angel
Published: September 2021

The influence of socioeconomic status (SES) on access to standard chemotherapy and/or monoclonal antibody therapy, and associated secular trends, relative survival, and excess mortality, among diffuse large B-cell lymphoma (DLBCL) patients is not clear. We conducted a Hong Kong population-based cohort study and identified adult patients with histologically diagnosed DLBCL between 2000 and 2018. We examined the association of SES levels with the odds and the secular trends of receipt of chemotherapy and/or rituximab. Additionally, we estimated the long-term relative survival by SES utilizing Hong Kong life tables. Among 4017 patients with DLBCL, 2363 (58.8%) patients received both chemotherapy and rituximab and 740 (18.4%) patients received chemotherapy alone, while 1612 (40.1%) and 914 (22.8%) patients received no rituximab or chemotherapy, respectively. On multivariable analysis, low SES was associated with lesser use of chemotherapy (odd ratio [OR] 0.44; 95% CI 0.34–0.57) and rituximab (OR 0.41; 95% CI 0.32–0.52). The socioeconomic disparity for either treatment showed no secular trend of change. Additionally, patients with low SES showed increased excess mortality, with a hazard ratio of 2.34 (95% CI 1.67–3.28). Improving survival outcomes for patients with DLBCL requires provision of best available medical care and securing access to treatment regardless of patients’ SES.
Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
Authors: Sandström Anna , Snowden Jonathan M. , Bottai Matteo , Stephansson Olof , Wikström Anna-Karin
Published: September 2021

The objective was to evaluate the sequentially updated predictive capacity for preeclampsia during pregnancy, using multivariable longitudinal models including data from antenatal care. This population-based cohort study in the Stockholm-Gotland Counties, Sweden, included 58,899 pregnancies of nulliparous women 2008–2013. Prospectively collected data from each antenatal care visit was used, including maternal characteristics, reproductive and medical history, and repeated measurements of blood pressure, weight, symphysis-fundal height, proteinuria, hemoglobin and blood glucose levels. We used a shared-effects joint longitudinal model including all available information up until a given gestational length (week 24, 28, 32, 34 and 36), to update preeclampsia prediction sequentially. Outcome measures were prediction of preeclampsia, preeclampsia with delivery < 37, and preeclampsia with delivery ≥ 37 weeks’ gestation. The area under the curve (AUC) increased with gestational length. AUC for preeclampsia with delivery < 37 weeks’ gestation was 0.73 (95% CI 0.68–0.79) at week 24, and increased to 0.87 (95% CI 0.84–0.90) in week 34. For preeclampsia with delivery ≥ 37 weeks’ gestation, the AUC in week 24 was 0.65 (95% CI 0.63–0.68), but increased to 0.79 (95% CI 0.78–0.80) in week 36. The addition of routinely collected clinical measurements throughout pregnancy improve preeclampsia prediction and may be useful to individualize antenatal care.
Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells
Authors: Daimon Etsuko , Shibukawa Yukinao , Thanasegaran Suganya , Yamazaki Natsuko , Okamoto Nobuhiko
Published: September 2021

Macrothrombocytopenia is a common pathology of missense mutations in genes regulating actin dynamics. Takenouchi-Kosaki syndrome (TKS) harboring the c.191A > G, Tyr64Cys (Y64C) variant in Cdc42 exhibits a variety of clinical manifestations, including immunological and hematological anomalies. In the present study, we investigated the functional abnormalities of the Y64C mutant in HEK293 cells and elucidated the mechanism of macrothrombocytopenia, one of the symptoms of TKS patients, by monitoring the production of platelet-like particles (PLP) using MEG-01 cells. We found that the Y64C mutant was concentrated at the membrane compartment due to impaired binding to Rho-GDI and more active than the wild-type. The Y64C mutant also had lower association with its effectors Pak1/2 and N-WASP. Y64C mutant-expressing MEG-01 cells demonstrated short cytoplasmic protrusions with aberrant F-actin and microtubules, and reduced PLP production. This suggested that the Y64C mutant facilitates its activity and membrane localization, resulting in impaired F-actin dynamics for proplatelet extension, which is necessary for platelet production. Furthermore, such dysfunction was ameliorated by either suppression of Cdc42 activity or prenylation using chemical inhibitors. Our study may lead to pharmacological treatments for TKS patients.
Mathematical model for the tensile strength of the crimping assembly of aviation wiring harness end
Authors: Li Pin , Liu Gongping , Fan Junhua , Sun Jiyuan , Xiu Hang , Tian Chunlin
Published: September 2021

In this study, the relationship between the tensile strength and the indentation depth was studied by analysing the deformation mechanism of the crimping assembly of the aviation wiring harness end. Tensile strength tests were performed on samples of crimping assemblies with different indentation depths. The results showed that the experimental and theoretical values were in good agreement, verifying the validity of the established mathematical model for tensile strength. Based on this model, a reasonable design range for the indentation depth corresponding to the specific combination of contacts and strands was determined.
Deglacial bottom water warming intensified Arctic methane seepage in the NW Barents Sea
Authors: El bani Altuna Naima , Rasmussen Tine Lander , Ezat Mohamed Mahmoud , Vadakkepuliyambatta Sunil , Groeneveld Jeroen , Greaves Mervyn
Published: September 2021

Changes in the Arctic climate-ocean system can rapidly impact carbon cycling and cryosphere. Methane release from the seafloor has been widespread in the Barents Sea since the last deglaciation, being closely linked to changes in pressure and bottom water temperature. Here, we present a post-glacial bottom water temperature record (18,000–0 years before present) based on Mg/Ca in benthic foraminifera from an area where methane seepage occurs and proximal to a former Arctic ice-sheet grounding zone. Coupled ice sheet-hydrate stability modeling shows that phases of extreme bottom water temperature up to 6 °C and associated with inflow of Atlantic Water repeatedly destabilized subsurface hydrates facilitating the release of greenhouse gasses from the seabed. Furthermore, these warming events played an important role in triggering multiple collapses of the marine-based Svalbard-Barents Sea Ice Sheet. Future warming of the Atlantic Water could lead to widespread disappearance of gas hydrates and melting of the remaining marine-terminating glaciers.
Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers
Authors: Fan Qingqing , Gao Yuan , Mazur Federico , Chandrawati Rona
Published: September 2021

We provide an overview of recent advances in colorimetric sensors to detect neurodegenerative disease biomarkers. Sensing strategies, limitations, and challenges are discussed, and an outlook on the future of this field is included.
Oxide-based composites: applications in thermo-photocatalysis
Authors: Barba-Nieto Irene , Gómez-Cerezo Natividad , Kubacka Anna , Fernández-García Marcos
Published: September 2021

Recent progress on oxide-based thermo-photocatalytic composite systems. Role of plasmonic, defect-related, and thermal effects on the catalytic performance.
Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications
Authors: Izbudak Burcin , Cecen Berivan , Anaya Ingrid , Miri Amir K. , Bal-Ozturk Ayca , Karaoz Erdal
Published: September 2021

In this review, we study potential applications of LDHs for tissue engineering and discuss some recent studies on biocompatibility, antibacterial and osteogenic differentiation behaviors of LDHs.
The first amorphous and crystalline yttrium lactate: synthesis and structural features
Authors: Yapryntsev A. D. , Baranchikov A. E. , Churakov A. V. , Kopitsa G. P. , Silvestrova A. A. , Golikova M. V. , Ivanova O. S. , Gorshkova Yu. E. , Ivanov V. K.
Published: September 2021

The synthesis and crystal structure of the first molecular yttrium lactate complex, Y(Lac)3(H2O)2, is reported, where the coordination sphere of yttrium is saturated with lactate ligands and water molecules, resulting in a neutral moiety.
Interfacial study of clathrates confined in reversed silica pores
Authors: Mileo Paulo G. M. , Rogge Sven M. J. , Houlleberghs Maarten , Breynaert Eric , Martens Johan A. , Van Speybroeck Veronique
Published: September 2021

Unravelling structure–property relationships allowing clathrate stability on hydrophobized silica pores. Cyclic and medium-sized chain alkane ligands form suitable ligands for clathrate stabilization.
Observation of memory effects associated with degradation of rechargeable lithium-ion cells using ultrafast surface-scan magnetic resonance imaging
Authors: Romanenko Konstantin , Jerschow Alexej
Published: September 2021

Batteries share their “health problems” and “memories” of hazardous life-cycle events via DC-induced magnetic field patterns revealed by MRI.
Single crystal field-effect transistor of tetrabenzoporphyrin with a one-dimensionally extended columnar packing motif exhibiting efficient charge transport properties
Authors: Zhu Juanjuan , Hayashi Hironobu , Chen Meng , Xiao Chengyi , Matsuo Kyohei , Aratani Naoki , Zhang Lei , Yamada Hiroko
Published: September 2021

The single crystal field-effect transistor of 5,15-bis(triisopropylsilyl)ethynyltetrabenzoporphyrin exhibited better hole mobility than its metal complexes, with efficient charge transport through π–π stacking along tetrabenzoporphyrin units.
Research on Clean Heating Technology in Northern Urban China
Authors: Li Yuxing , Shi Yu , Li Hao , Gao Xuefeng , Zhu Yeyang
Published: September 2021

Currently, with the rapid development of small towns in China, residents’ heating demand has been increasing, which exposes the heating problems of the small towns. Especially in the heating season, the energy consumption of buildings accounting for a decent proportion and the increase in pollution emissions can seriously affect the lives of residents. To alleviate these problems and promote clean heating, it is necessary to investigate the resources situation of small towns and design targeted heating lines for load areas. Therefore, this article used data analysis, described the population, construction area and industrial structure of small towns in the northern region, summarized the current development trend of small towns in China. Besides, taking the small towns in Inner Mongolia Autonomous Region as an example, this paper tried to understand the heating problems of small towns, including low energy efficiency of thermal energy and poor thermal insulation of buildings. Based on the supply and demand side of small towns and the differences in the endowment characteristics in various regions, this paper also proposed different clean heating technology paths.
A Study on the Prosperity Index and Cycle Measurement of China Air Cargo Transport
Authors: Ge Jinmei
Published: September 2021

The business cycle of the Air cargo in China is investigated in this paper. Both the composite indicator (CI) and the diffusion indicator (DI) are derived and the benchmark date is determined. The composite index is synthesized by 10 indicators using correlation analysis and the method of NBER. Then the spectral method is adopted in use of the CI to identify the the major cycle of air cargo in China. By the CI, there is a major cycle with the length of 3,6 years. The major cycle of air cargo in China keeps pace with the the global trade fluctuation. The cycle of air cargo of China is compared with the United States, and the railway cargo of China. The author finds out that the major cycle of the air cargo is basically consistent with the USA in the same period. Combined with the prosperity index, it illustrates that the growth of air cargo in China will reach a peak in around 2021-2022, considering the growth of global trade and the leading prosperity index.
A study on the optimization strategies for the service trade structure of Guangdong-Hong Kong-Macao Greater Bay Area
Authors: Li Wenyong , Zhang Xueyu , Tang Bing’e
Published: September 2021

The construction of urban agglomerations and integration of regional economics have become the new trends in Chinese economic development. The economy of Guangdong-Hong Kong-Macao Greater Bay Area plays a significant role in driving regional development and stimulating technological innovation. In this paper, through study on the current situation of trade in service in Guangdong-Hong Kong-Macao Greater Bay Area, the reasons for the improper trade structure are concluded. Through data and case analysis, the factors affecting service trade structure are located. The results of case analysis can offer some useful and viable recommendations for the optimization of service trade structure, which can facilitate the industrial transformation and upgrading in Guangdong-Hong Kong-Macao Greater Bay Area as well as give a fresh impetus to economic growth.
The impact of new energy development on economic growth
Authors: Liu Renrui
Published: September 2021

With the proposal of a sustainable development strategy, the development of new energy is accelerating day by day. The impact of new energy on economic growth has become increasingly apparent. Therefore, this article will analyse the characteristics and development status of new energy. This article focuses on the analysis of the development of new energy in China, including the current data on wind energy and biomass energy in China, so as to put forward the influence factors of the development of new energy on economic construction. At the same time, it also proposed a new energy development strategy centred on economic growth. The purpose of this article is to guide the coordinated development of new energy development and economic growth.
Research on Fire Protection Methods of Cables in Substations
Authors: Xue Kai , Wang Zheng , Ren Chunguang , Wang Huixia , Li Feng
Published: September 2021

The normal operation of the substation is inseparable from the important guarantee of the cable. The cables in the substation are not only widely distributed, but also the cables are flammable and spread easily after fire. Once a cable catches fire, the consequences will be disastrous. Therefore, how to fire the cable becomes an important task for the power system. Many engineers and technicians continue to analyze and study the causes of cable fires, but cable fire accidents still occur from time to time. In order to solve the problem of cable fire protection and existing problems, the article combines actual research and analysis, and gives the most effective and safe cable fire protection method．
Research on the Development of Blockchain in Supply Chain
Authors: Zheng JunJie , Ye TianFeng
Published: September 2021

At the present stage, China’s economy is at a critical stage of transformation and development, and supply chain finance has also entered a deep stage of development. In order to promote supply chain finance to get rid of hollowing out and other traps, it is necessary to improve the way of financial information service. Some characteristics of blockchain technology are consistent with the development of supply chain finance, which can improve the industry’s ability to control risks related to supply chain finance to a certain extent, and make supply chain finance better serve the real economy.On the basis of previous basic research, this paper creatively puts forward how to use blockchain to solve the problems existing in supply chain finance, and discusses in detail the obstacles to the popularization of blockchain technology in the field of supply chain finance, thus providing some schemes for realizing the application of blockchain in the field of supply chain finance.
Research on the development mode of digital channels of commercial banks based on blockchain finance
Authors: Yang Shuaiyin , Han Xiaoyang , Tian Gengyuan , Tuo Haiyue
Published: September 2021

—In 2021, blockchain was included in the national five-year plan for the first time, and in the chapter of “Accelerating Digital Development and Building Digital China”, blockchain was listed as one of the seven key industries of digital economy in the 14th Five-Year Plan. The rapid development of blockchain technology not only promotes the high-speed operation of China’s real economy and greatly improves the overall service quality of China’s digital economy, but also provides new development ideas for the innovative development of digital channels of commercial banks. In this paper, through the use of literature research method and qualitative analysis method, we deeply analyze the challenges faced by the development mode of commercial banks at the present stage, etc. Accordingly, we propose corresponding countermea-sures and suggestions from the perspectives of research and development of technology, customer privacy protection and improvement of service efficiency, so as to continuously empower the digital transformation of commercial banks in China.
Research on the Collaborative Cultivation Mode of Logistics Specialty Talents under the Background of “New Business”
Authors: Lei Zhao , Yanhua Zhang
Published: September 2021

With the development of the Internet and E-Commerce, logistics has maintained a sustained and rapid development trend since the 1980s. Its industry scale and service capacity have been significantly improved. It has become a new economic growth point in China, and logistics has become a pillar industry in the development of the national economy. With the vigorous development of logistics industry, more logistics talents are needed, and universities are the cradle of training talents. The logistics personnel training is far behind the logistics market demand, and those practice is weak during the process of the logistics professional teaching with the theory. Therefore, if there is chance to make a breakthrough, must rely on practical teaching to strengthen logistics theory and practice combination, with the help of practice process to improve the students’ practical ability, related handling problems and straining capacity, including effectively improvement the comprehensive ability of students, for achievement the effective docking of school education and enterprises. Production-University-Research Collaboration training is an important way to cultivate students’ practical ability and innovation ability, and it is also a new highlight of application-oriented universities, colleges and universities, as a new way to cultivate talents. School-enterprise integration practice teaching is the way to cultivate innovative talents and the core goal of higher education teaching reform in the new era. The collaborative cultivation mode of logistics talents provides an implementation plan for improving students’ practical ability, practical ability, problem-solving ability and strain ability, and also provides a specific realization path for logistics professionals, to provide comprehensive talents more in line with the needs of enterprises. Therefore, under the background of new business, it is necessary to strengthen the cooperation between logistics industry and enterprises, and strengthen the research mode of collaborative education of professional talents oriented by industry-university-research. On the one hand, it is conducive to the cultivation of applied talents in colleges and universities, and on the other hand, it lays a favorable foundation for our school to cultivate applied talents serving local areas.
An Analysis of the Current Situation of the Research on the Influencing Factors of M & A Performance of Listed Companies
Authors: Zhang Guohui , Lin Dongchuan , Wang Yeling , Lei Bingxi
Published: September 2021

M & A was an important means to promote the transformation and upgrading of traditional industries, and also an important way to improve the degree of industrial concentration and speed up the transformation of industrial development mode. As a direct embodiment of the efficiency of M & A, the performance of M & A has been widely concerned by scholars. This paper introduced the concept of M & A performance and motivation of M & A, used Citespace to analyze 749 papers on M & A performance from CNKI core journals from 2000 to 2020,The research focus and frontier of M & A performance a analyzed by keyword clustering and keyword variation, and analyzed the research results of external environment, internal environment, M & A characteristics and external intermediary agencies which affect M & A performance, Finally, the possible direction of future research was proposed.
Economic Factors Analysis and Optimization Strategy of Third-generation Nuclear Power
Authors: Fang Zhou
Published: September 2021

Due to the project delay, the construction price of the first unit of the two types of third-generation nuclear motor type AP1000 and EPR in China is higher than the local benchmark price of coal. If the delay is not considered, only the first unit factor is considered, the price should be between 0.48-0.49 yuan/kWh. Compared with the construction period and electricity price of solar power generation and wind power, this price still has no advantage. Therefore, the economic efficiency of nuclear power has become a key factor to determine whether nuclear power can occupy a place in the future power market and then get rapid development. In this paper, combined with the construction experience of third-generation nuclear power in China, a comprehensive economic analysis of nuclear power is carried outfrom the design requirements, equipment procurement, construction period, financing channels, operation and maintenance strategies and other factors, so as to provide direction guidance for the economic improvement of the subsequent batch construction of the third-generation nuclear power and the better participation of nuclear power in the power market competition.
Analysis on financing structure and default probability of listed companies
Authors: Luo Xiangyun , Luo Miao
Published: September 2021

This paper studies the relationship between the financing structure and the probability of default of A-share listed companies from 2001 to 2020. The purpose is to prevent the occurrence of default and ensure the healthy development of various industries. It is found that the higher the proportion of external financing is, the higher the probability of default is. The impact of debt financing on default risk is higher than equity financing. In addition, this paper tests the mediating effect of cash flow risk, and the effect of financing structure on debt default probability is heterogeneous among regions and enterprises. These findings show that enterprises must control their financing structure, optimize the allocation of resources, prevent cash flow risk, reduce the probability of debt default, so as to make various industries flourish and optimize the industrial structure.
Research on the dynamic relationship between listed company team and social financing scale: based on VAR model
Authors: Mengdong Chen , Lijun Wang
Published: September 2021

Social financing scale is an important indicator reflecting financial services to the real economy. This paper uses the VAR model to explore the dynamic relationship between the ranks of listed companies and the scale of social financing. The empirical results show that: There is a long-term equilibrium relationship between the number of listed companies and the scale of social financing, which can boost the expansion of the scale of social financing, but the expansion of the ranks of listed companies has no obvious effect on the immediate boost of the scale of social financing. The “increase in the number” of listed companies in China may imply “low quality”. The number of listed companies has a delayed effect on the scale of social financing. In the long run, the expansion of the ranks of listed companies does.
Research on the development of new energy industry based on A company
Authors: Lv Yihang , Kong Jingjing
Published: September 2021

China’s energy development in the new era not only provides strong support for China’s sustained and healthy economic and social development, but also makes positive contributions to maintaining world energy security, coping with global climate change and promoting world economic growth. Taking domestic hydrogen listed company a as an example, this paper analyzes the theory and data from the aspects of business model, core competitiveness and financial report in 2020, and finds that even with strong competitiveness, the business performance of company a, which has no major problems in business model, has suffered losses. In the future, the company or the development industry should be improved from both internal and external aspects. At the internal level, actively and steadily improve the management quality, increase R & D efforts, optimize the project delivery process, and implement the financial intelligent transformation. At the external level, we are actively developing the market and expanding business. At the same time, we should strengthen publicity to the society and the public to guide consumers to trust and choose new energy products. The purpose of this paper is to provide some help for promoting the development of new energy industry in China.
Research on R&D Investment, Corporate Leverage and Firm Performance: Based on Chinese Manufacturing Industry
Authors: Gao Yuan
Published: September 2021

With the development of science and technology, Chinese manufacturing industry is facing transformation and upgrading, and innovation is an important driving force to promote industrial transformation and upgrading. Therefore, based on the background of Chinese manufacturing transformation and upgrading, this paper uses fixed effect model to study the relationship between R & D investment and corporate performance, and the moderating effect of corporate leverage. The study finds that the greater the R & D investment of enterprises is, the better the performance of enterprises is. Meanwhile, the leverage of enterprises has a negative moderating effect on the relationship between R & D investment and enterprise performance. Therefore, enterprises should pay attention to their own R & D, reduce their debt levels, and promote the transformation and upgrading of enterprises. At the same time, the government should introduce corresponding preferential policies to encourage enterprises to carry out R & D and deleverage, in order to promote the healthy development of industrial economy.
Research on the impact of innovation input on enterprise performance in manufacturing enterprises--- Moderating effect based on governance structure
Authors: Zhao QianYu , Fu Gang , Liu WanTing
Published: September 2021

Manufacturing industry is the lifeblood of national economy, and innovation input is the lifeline of manufacturing enterprises. This paper selects the financial data of China’s listed manufacturing companies from 2015 to 2019 to study the moderating effect of governance structure on the relationship between innovation input and firm performance. It is found that innovation investment has a negative influence on firm performance with lag. In terms of ownership structure, ownership concentration has a negative moderating effect on the relationship between innovation input and firm performance. The degree of equity balance has a positive moderating effect on the relationship between innovation input and firm performance. According to the conclusion of this study, it is expected to optimize the governance structure of China’s manufacturing enterprises and promote industrial development.
Construction and Thoughts of Intelligent “Three-Prevention” System in Shenzhen
Authors: Changjie Liu , Yiqing Xiao , Bo Zhang , Bijia Zhang , Shufeng Xi , Yuanyuan Jiao
Published: September 2021

Modern science and technology is a weapon against natural disasters. Shenzhen is a city of technology and innovation and we should endeavor to address flood control, drought relief and wind mitigation (named “three-prevention” in this context). In particular, we should vigorously promote the improvement of technology, and make use of modern information technologies such as big data, internet of things, cloud computing and artificial intelligence to create intelligent three-prevention system. This paper described in detail the characteristics and the construction status of the intelligent three-prevention system as well as the future development direction, in order to achieve the construction goals of the overall situation probing of the three-prevention, real-time decision-making assistance, flat command and control and urban resilience development. Since the intelligent three-prevention system’s launch in April 2020, it has started more than 20 times of emergency response against typhoon and flood. The whole process functions of front-end intelligent perception, fine dynamic simulation, real-time forecast and early warning, emergency command and post-disaster assessment have been preliminarily realized.
Research on Intelligent Analysis of Illegal Food Safety Behavior Based on Deep Learning Algorithm
Authors: Yang Bing , Chen Kai , Wang Yajie , Tan Hong , Wang Fugui , Wang Minghui
Published: September 2021

Food safety has been a major concern in recent years as a result of numerous food safety events in many nations. This could increase the health risks associated with eating low-quality food, lowering customer confidence in food safety. It is critical to overcome this challenge and gain consumer trust in order to improve food quality and safety. To address this issue, we suggested an intelligent deep learning method for identifying which foods are potentially harmful to human health based on chemical and additive qualities, which could have a significant impact on consumer health. The findings of our survey show that deep learning surpasses other methods such as manual feature extractors, as well as the promising findings of categorization of hazardous food, further research efforts to apply deep learning to the field of food will be made in the future.
The Impact of Construction Industry Structure Optimization on the Economy of Metropolitan Area - Taking Hefei and Nanjing Metropolitan Area as Examples
Authors: Juyan Cui , Ziyang Wang , feiyang Chen
Published: September 2021

This research selected Hefei and Nanjing metropolitan area as the research object to analyze the optimization of construction industry structure in Hefei and Nanjing metropolitan area in 2018. Firstly, the construction industry structure rationalization analysis, heightened analysis, specialization analysis and similarity analysis were conducted for Hefei and Nanjing metropolitan areas, then the theory of construction industry structure optimization analysis was derived for Hefei and Nanjing metropolitan areas, and then ArcGIS technology was used to draw the spatial distribution map of construction industry structure in the two metropolitan areas to provide theoretical support for industrial structure optimization and high-quality construction of Hefei metropolitan area. Finally, the analysis concluded that in the process of synergistic development, the Hefei metropolitan area should focus on strengthening the synergistic development with Nanjing metropolitan area, so that the Yangtze River Delta region can achieve the optimization of economic structure preferably, advanced industrial base and modernization of industrial chain, and enhance the coordination of urban and rural regional development, thus making significant progress in the construction of modernized economic system.
The Dilemma Faced by Dongguan Foreign Trade Companies in the Post-epidemic Era and Transformation Development Research
Authors: Liang Jiahui , Lei Fei , Deng Yingtong
Published: September 2021

The gradual increase in China’s economic strength has driven the economic development of the foreign trade industry. However, due to the impact of the new coronavirus in 2020, many countries and cities have suffered economic recession, companies have closed down, and flights have been suspended. Therefore, the development of Dongguan’s foreign trade enterprises has also been hit to a certain extent, and many problems have appeared. During the post-epidemic period, Dongguan foreign trade companies faced problems such as lack of human resources, difficulties in resuming work and production, obstacles in logistics and transportation, and substantial increase in costs. This article analyzes the difficulties faced by Dongguan’s foreign trade enterprises, and puts forward countermeasures to seek the transformation and development of foreign trade enterprises.
Research on the development of Changbai mountain summer tourism from the perspective of consumer behavior
Authors: Jin Yanan , Li Xiaomei
Published: September 2021

In the context of global warming, the development of the summer tourism industry has maintained a rising trend, and has gradually become a key area of widespread concern and continuous innovation by the government, tourism companies, scientific research, and the media. This paper takes domestic tourists who go to Changbai Mountain for summer travel as the research object, using the online travel notes of many travel websites such as Mafengwo and Ctrip as the data source, with the help of NLPIR big data semantic intelligent analysis platform, using text mining, network analysis, co-occurrence analysis and other methods to analyze the text data of travel notes quantitatively and qualitatively. The characteristics and laws of Changbai Mountain summer tourism consumer behavior are analyzed from three aspects: tourism decision-making behavior, tourism consumer preference, and post-tour evaluation.
Research on the Countermeasures of Collaborative Innovation in China’s Strategic Emerging Industries
Authors: Xiaohong Li , Wenqian Gou
Published: September 2021

Collaborative innovation is an effective way to promote the development of strategic emerging industries, enhance industrial competitiveness, and promote economic development. This article combines the development status of strategic emerging industries and the status of collaborative innovation in strategic emerging industries, and proposes mechanisms and countermeasures to promote collaborative innovation in strategic emerging industries. The research results are of great significance for enhancing the collaborative innovation capability of strategic emerging industries and promoting the development of strategic emerging industries.
International Development of Chinese Cultural Tourism Industry ——Based on the Perspective of Intercultural Communication
Authors: Yibing Yu
Published: September 2021

In the context of “the Belt and Road”, cultural tourism has made rapid development. The integration of culture and tourism brings new challenges to tourism industry. The major project of cultural tourism communication is how to conduct intercultural communication in the context of foreign cultures. The study analyses the intercultural communication model and the problems of cultural tourism communication from the perspective of culture shock and cultural tourism translation, and presents the specific strategies including improving the quality of text translation of cultural tourism, and strengthening effectiveness of cultural tourism communication, and cultivation of tourism talents, which helps promote the soft power of cultural tourism communication.
Effects of drought stress on soil bacteriall community in the West foot of Daxing’an Mountains
Authors: Wei Shuli , Fang Jing , Shi Gongfu , Cheng Yuchen , Wu Jianhui , Su Erhu , Liu Zhixiong , Lu Zhanyuan , Zhao Xiaoqing
Published: September 2021

Global warming poses a serious threat to agriculture and natural systems, in part because of the change of soil moisture content, which changes soil microbial communities and ecological processes. Soil water content is the main factor limiting the growth of plants in soil. Microbial communities rely on soil water to complete their activities, and reveal the changes of underground microbial communities under different soil moisture content, which will help us to further understand the potential impact of climate change on soil ecosystem. To investigate the soil bacterial community structure, we established experiment indoor in the West foot of Daxing’an Mountains with manipulative water content treatments consisting of 20%, 15%, 10%, 5%, 0%. Results showed that bacterial community composition varied significantly with altered drought stress , but community richness did not. The relative abundance of Actinobacteria increased with the increase of drought stress, Proteobacteria, Acidobacteria and Gemmatimonadota decreased with the increase of drought stress, actinobacteria was more likely to accumulate or maintain stable under drought stress, bacterial communities can responding directly to changes in soil moisture.
A network pharmacology approach to explore Dahuang on colon cancer
Authors: Wang Mai , Wang Yinyue , Wang Shu
Published: September 2021

To investigate the mechanism of action of Rhubarb (Dahuang) in the treatment of colon cancer by network pharmacological method. TCMSP database was used to screen the active components and action targets of Rhubarb, Genecards database was used to screen the relevant action targets of colon cancer, Venny 2.1.0 software was used to make the intersection of Rhubarb and colon cancer, and the potential targets of Rhubarb for the treatment of colon cancer were obtained.Cytoscape 3.7.2 software and the STRING database were used to construct the component-target network of Rhubarb active components and colon cancer related targets. The important targets were obtained by analyzing the network, and the GO and KEGG pathway enrichment analysis was performed on them using Metascape database. Sixty active ingredients including EUPATIN, Mutatochrome, Physciondiglucoside, Procyanidin B-5,3’ -o-gallate, rhin were screened from Rhubarb, which could act on 61 colon cancer related targets.Among them, 13 targets, including PTGS2, IL1B and Bax, are important targets, which may be involved in various biological processes such as the response to the regulation of colon cancer nutritional level, the homeostasis of multicellular organisms and the regulation of peptide secretion through the regulation of PI3K and other pathways. Rhubarb can participate in the treatment of colon cancer through multi-target and multi-pathway.
Advance of Etiologies and Treatments on Schizophrenia
Authors: Chen Jiayu , Feng Ruijie , Ma Ziyuan
Published: September 2021

Schizophrenia is a severe psychiatric disorder. Among the globe, almost 70% of people with schizophrenia would experience hallucinations that make them feel insecure and progressively weakened. Etiologies and treatments of this perilous disease, therefore, are supposed to be studied in depth. Although the exact causes are still unknown, scientists highly suggest that this disorder results from the combination of genes and environments. For genetic influences, genes such as NR3C2, Dysbindin-1 (DTNBP1), Neuritin-1 (NRN1), KPNB3, and KPNA3 play insignificant roles in the development of schizophrenia. For environmental influences, researchers collected data from different aspects to infer the causes of schizophrenia. The reasons, including season of birth, urbanization, are not related to schizophrenia causation. Furthermore, if pharmacological interventions such as chlorpromazine, followed by some psychotherapy at an early stage, schizophrenia has a chance of being cured and not relapsing. Many drugs on the market target G-protein-coupled receptors. To improve their bioavailability, a new technique called lipid-based self-nanoemulsifying drug delivery systems formulations assists with the absorption of them.
Research progress of natural plant products inducing apoptosis of tumor stem cells
Authors: Nishang Liu , Yulin Liu , Yinyue Ma
Published: September 2021

Compared to general cancer cells, cancer stem cells are stronger and more difficult to be killed by drugs. Therefore, traditional treatment methods have low efficacy according to cancer stem cells. In essence, one of the main causes of cancer survival, proliferation, transfer, and recurrence is the presence of cancer stem cells. In recent years, a large number of studies have demonstrated that natural plant products have powerful in killing cancer cells and have various structures, which possess low toxicity, multi-target regulation advantages in inducing cancer stem cells to apoptosis. Therefore, this provides new ideas for developing anti-cancer drugs by inducing cancer stem cell apoptosis by natural plant products. In this article, we will introduce the apoptotic mechanism of tumor stem cells, the importance of eliminating tumor stem cells, and the benefits of natural plant products in cancer treatment. In addition, this paper reviewed nine categories of chemicals in natural plant products that induce apoptosis of tumor stem cells and their mechanisms of action. We also summarized the mechanism of natural plant products inducing apoptosis of tumor stem cells. This review provides an important reference for the personalized treatment of cancer.
Clinical Study on the Influence of Eye Care Habits on Myopia in School-age Children
Authors: Meihong Zhu , Tainan Lin
Published: September 2021

In order to explore the relationship between the habit of using eyes and myopia, summarize and put forward to develop good habit of using eyes of school-age children to achieve the purpose of preventing myopia. 960 school-age children aged 7 to 12 were selected from the ophthalmology clinic of Fujian Provincial Government Hospital. The data collected included reading distance, sleep time, average daily outdoor activity time, average daily continuous eye use time. Ophthalmologists are responsible for visual examination, which includes mild myopia, moderate myopia and severe myopia. SPSS 22.0 statistical software was used for data processing. As a results, P < 0.05 was statistically significant. There are significant differences in the distribution of sleep time among the three groups (P < 0.05); There are significant differences in the time distribution of each continuous close eye use among the three groups (P < 0.05); There are significant differences in the distribution of distance habit among the three groups (P < 0.05); There are significant differences in the distribution of outdoor activity time among the three groups (P < 0.05).Myopia is closely related to the time of close eye use, the distance of eye use, the length of sleep and the length of outdoor activities.
Research on the combined effects of traditional Chinese medicine compound Based on physical movement Theory
Authors: Li Changlei , Chen Xiaoqing , Yi Huiling , Xiong Zhe , Ma Baomiao
Published: September 2021

Methamphetamine (METH) is a powerful psychostimulant. Chronic obsessive and compulsive usage of METH caused great harm to human health (physical and psychological) and social stability issues all over the world. Currently, no drugs have been used to treat and prevent METH addiction. Our previous studies demonstrated that Chinese medicine compound (JDYH) can inhibit METH-induced sensitization in mice. To investigate the combined effects of JDYH on physical movement in C57BL/6 male mice. In the experiment, mice chronic treatment with JDYH (14.12-56.48 g/kg) for 28-30 days, physical movement activity and body weight was measured. The body weight and physical movement have no change after being treated with low-dose (14.12 g/kg) and mid-dose (28.24 g/kg) of chronic treatment with JDYH. These results suggest that JDYH (14.12-28.24 g/kg) for 21days were not inhibit physical movement in mice.
Investigation on Reproductive Health Knowledge Cognition and Service Demand of University Students——Based on Three Universities in Huangjiahu University Town
Authors: Jia-miao Hou , Li-na Shuai
Published: September 2021

The paper aims to provide a reference for policy-making on reproductive health services for university students by investigating the recognition degree of reproductive health knowledge and current status of reproductive health service needs of students of three universities in Huangjiahu University Town. The author carries out the questionnaire surveys in the three universities using “wjx”, a platform for questionnaire-making, then adopts descriptive analysis and spss analysis to process the data obtained from the questionnaire survey. Sexual behavior among university students is a common phenomenon. However, due to the low cognition degree of reproductive health, they have a strong demand for reproductive health services.