bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Characteristics And Analysis Of Risk Factors For Disease Progression Of COVID-19 Among Patients Within Wad Medani Isolation Centers, Gezira State: A Retrospective Cohort Study From Sudan
Authors: Yousif Mohammed Yousif Elnaeem , Eljack Moh.Mah.Fadel Allah , Amir Osman , Alfatih Mohammed , Shiekh Akram Khalid Al Tigany Al , Ahmed Mazin Abdelraham Osman , Nour Alshareef , Haroun Mazin S. , Ahmed Khabab Abbasher Hussien Mohamed , Alhusseini Radi Tofaha , Osman Waddah Aljaely Mohammed , Abdulkarim Mohamed , Omer Mohammed Eltahier Abdalla
Published: October 2021

Background :

(COVID-19) had a great impact on the world’s health systems since December 2019. A little is known about the clinical characteristics and risk factors associated with COVID-19 severity in Sudanese Patients; therefor it is necessary to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors associated with COVID-19 severity.
Methods :

A one-year retrospective cohort study (May 2020- May2021) was done at three isolation centers in Wad Medani. Sample contained all COVID-19 patients who are over 18 years old and were confirmed to be COVID-19 by nucleic acid testing or features Suggestive of Covid19 on Chest CT scan.
Results :

This study included 418 patients confirmed COVID-19 cases with a median age of 66.3±13years. 179 (64.2%) patients were men. Hypertension (n=195; 46.7%) and diabetes (n=187; 44.7%) were the most common comorbidities. The most common symptoms at COVID-19 onset were fever (n=303; 72.5%), cough (n=278; 66.5%) and dyspnea (n= 256; 61.2%). the overall mortality rate was 35.4% (n=148). The morality rate was 42.3% (n=118) among patients with severe disease. The Chi-square test and ANOVA analysis revealed that older age, anemia, neutrophilia and lymphcytopenia, higher glucose levels, HbA1c levels and creatinine levels were variables associated with severe COVID-19. In inflammatory markers, the levels of CRP and d-dimer were elevated in severe infection more than moderate and mild infections.
Conclusion :

Patients with these factors are more likely to deteriorate into severe infection and have higher mortality rate than those without these factors.
Microseismic network sensitivity in case of no seismic activity
Authors: Káldy Eva , Fischer Tomáš
Published: October 2021

Underground human activities, such as mining, shale gas and oil exploitation, waste-water disposal or geo-thermal plants, can cause earthquakes. These industry projects need to be monitored by local seismic networks in order to contain the risk. An ideal seismic network should have a triangulated grid, with spacing equal to the depth of the industrial activity with no associated industry noise. In many cases, stations are placed near noisy roads, factories or in a private garden, none of which are located at optimal nodes and which thus introduce great variations in the nose level. In this article, we present a work-flow to determine the sensitivity of any local network, even if there is no local event recorded. In other words: how small are the earthquakes that such seismic networks detect? This knowledge can be used as an argument for claiming an area to be seismically silent-inactive down to a certain magnitude or for evaluating the effect of an additional seismic station.A brief theory and work-flow description is followed by two real-case demonstrations from Czech Republic, Europe: first, a proof-test on a well- studied seismically active area of West Bohemia / Vogtland and second, an application to an uprising geothermal project in Litoměřice, where no seismic activity was detected in years of monitoring.
A domain wall in twisted M-theory
Authors: Oh Jihwan , Zhou Yehao
Published: October 2021

We study a four-dimensional domain wall in twisted M-theory. The
domain wall is engineered by intersecting D6 branes in the type IIA
frame. We identify the classical algebra of operators on the domain wall
in terms of a higher vertex operator algebra, which describes the
holomorphic subsector of a 4d \mathcal{N}=1𝒩=1
supersymmetric field theory, and compute the associated mode algebra. We
conjecture that the quantum deformation of the classical algebra is
isomorphic to the bulk algebra of operators from which we establish
twisted holography of the domain wall.
Approaches to prevention of antibiotic-associated diarrhea in children
Authors: Pakhomovskaia N. L. , Tatyanina O. F. , Lazareva Т. Yu.
Published: October 2021

The incidence of antibiotic-associated diarrhea, according to various authors, ranges from 5 to 39% and depends on the patient’s age and other contributing factors. Antibiotic-associated diarrhea can be caused by any antibiotic, regardless of dosage form or route of administration. In the pediatric population, the prevalence of antibiotic-associated diarrhea ranges from 6 to 70%. An urgent problem is the development of this disease against the background of a course of H. pylori eradication therapy, which significantly complicates tolerance and adherence to therapy. This article presents current data on the pathogenesis and risk factors of antibiotic-associated diarrhea in children. The clinical picture ranges from idiopathic enteritis to antibiotic-associated diarrhea caused by Cl. difficile - pseudomembranous colitis.

The main principle of antibiotic-associated diarrhea treatment is cancellation of the antibacterial medicine that caused the diarrhea, or reducing its dose (if the course of the disease allows it). In complex treatment sorbents are used, correction of water-electrolyte balance is carried out. The use of probiotics seems quite logical for the treatment and prevention of antibiotic-associated diarrhea in terms of the pathogenesis of this condition. To correct dysbiosis, drugs are used to maintain and restore the quantitative and qualitative composition of the intestinal microbiota.

Taking into account modern recommendations the main groups of drugs (probiotics, prebiotics, synbiotics) used for correction of intestinal microbiocenosis are presented. The mechanism of action of probiotics and mechanisms of their effect on intestinal microflora are considered. The basic requirements for bacterial strains that are part of the probiotic drugs are presented.

The results of various randomized clinical trials and meta-analyses confirming the necessity of including probiotic complexes in antibiotic-associated diarrhea treatment regimens are presented from an evidence-based medicine perspective. The clinical effects of strains of Lactobacillusspp., Bifidobacterium spp.,Streptococcusspp. and Lactococcusspp. on the digestive tract microbiota are considered. The role of a synbiotic containing 9 probiotic strains of 4.5 * 109 CFU in one capsule and the prebiotic component fructooligosac-charides in the prevention of antibiotic-associated diarrhea in children is discussed separately. The results of microbiological studies confirmed the presence of microorganisms of genera Bifidobacterium, Lactobacillus, Streptococcus in the product, and the content of bacteria in one dose of the product was not less than 2 x 1010 CFU.
Development of the single window mechanism in the EAEU countries based on the analysis of foreign experience
Authors: Agapova A. V.
Published: October 2021

In order to develop the "single window" mechanism in Russia, the article analyzes the foreign experience of its application. The analysis of foreign experience in the development and implementation of the "single window" mechanism has shown that the simplification of the customs control procedure not only in the EAEU, but also in many countries of the world, indicates the effectiveness of such a mechanism in terms of documentary control over goods and vehicles of international transportation. It is established that all authorized state regulatory bodies of foreign countries use a single platform for obtaining and processing data on goods and participants of foreign economic activity, which allows linking the work of such state bodies into an integrated system. Such platforms are DAKOSY (Germany), PortNet (Finland), UNI-PASS (Republic of Korea), TradeXchange (Singapore) and ORBUS (Senegal). It was noted that the introduction of the "single window" mechanism in all foreign countries was carried out in stages. In addition, significant funding was allocated from the public-private partnership to create such a mechanism. The problems hindering the development of the "single window" mechanism in the EAEU are identified. The directions of development of the "single window" mechanism are developed taking into account foreign experience. In particular, a model of information interaction within the framework of the "single window" of the Russian Federation is proposed.
South Korea’s trade policy imperatives: the impact of COVID-19 pandemic
Authors: Kukla M. P.
Published: October 2021

The article analyses the goals and imperatives of the Republic of Korea’s trade policy before the COVID-19 pandemic and taking into account its consequences. The RoK's trade policy aims to synchronize the interests of the state, conglomerates and small and medium-sized enterprises. For this purpose, a system of division of powers in the field of trade policy and diplomacy has been designed, which has proven to be very effective. The COVID-19 situation, which has exacerbated the growing trend of protectionism in international trade, highlighted the chronic structural problems of trade in the Republic of Korea of trade in the area of geographical and commodity structure – despite the positive dynamics of the country's exports. The challenge of countering protectionism, coupled with the need to diversify the commodity and geographic structure of exports, implies two areas of work: strengthening an industrial structure capable of producing competitive goods and expanding the network of free trade agreements. The need to address logistical problems, digitalization, and the trend towards decarbonization forces Korea to rely more heavily on the idea of promoting free trade. The country's leadership continues to criticize protectionism, guided by the idea of a balanced use of bilateral and multilateral instruments of liberalization.
Association Between Cardiometabolic Index and Stroke: A Population-
based Cross-sectional Study
Authors: Li Feng-E , Luo Yun , Zhang Fu-Liang , Zhang Peng , Liu Dong , Ta Song , Yu Yao , Guo Zhen-Ni , Yang Yi
Published: October 2021

Background:

Cardiometabolic Index (CMI) was associated with several risk factors for
stroke; however, few studies assessed the role of CMI in stroke risk.

Objective:

This study aimed to assess the association between CMI and stroke in a population-
based cross-sectional study.

Methods:

This study included 4445 general residents aged ≥40 years selected by multistage stratified
random cluster sampling. CMI was calculated as the product of the ratio of waist circumference
to height (WHtR) and the ratio of triglyceride levels to high-density lipoprotein cholesterol
levels (TG/HDL-C). Participants were categorized according to CMI quartiles: quartile 1 (Q1),
quartile 2 (Q2), quartile 3 (Q3), and quartile 4 (Q4). Multivariate logistic regression analysis and receiver
operating characteristic (ROC) curves were used to assess the association between CMI and
stroke.

Results:

A total of 4052 participants were included in the study, with an overall stroke prevalence
of 7.2%. The prevalence of stroke increased with CMI quartiles, ranging from 4.4% to 9.2% (p for
trend <0.001). Compared with Q1, stroke risk for Q2, Q3, and Q4 were 1.550-, 1.693-, and 1.704-
fold, respectively. The area under the ROC curve (AUC) (95% CI) was 0.574 (0.558-0.589) for
CMI, 0.627 (0.612-0.642) for WHtR, 0.556 (0.540-0.571) for TG/HDL-C. CMI was inferior to
WHtR (p=0.0024), but CMI had a marginal advantage over TG/HDL-C (p<0.0001) in terms of its
stroke discrimination ability.

Conclusion:

Although there was a strong and independent association between CMI and stroke in
the general population, CMI had limited discriminating ability for stroke. Thus, new parameters
should be developed.
Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric
Illness: A Case Report
Authors: Sharma Verinder , Sharma Sapna , Doobay Minakshi
Published: October 2021

Background:

In this report, we describe a case of domperidone withdrawal in a woman
with a history of major depressive disorder and obsessive-compulsive disorder (OCD), who experienced
a recurrence of these disorders after stopping domperidone.

Case presentation:

The symptoms improved after the restarting of domperidone and disappeared
gradually as the drug was tapered and discontinued. Clinicians should consider domperidone withdrawal
a differential diagnosis in women with a history of depression or anxiety who present with
an acute onset of these symptoms following the abrupt discontinuation of domperidone.

Conclusion:

A gradual taper off of the drug may be effective in minimizing withdrawal symptoms
and obviate the need for psychotropic drug use.
Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review
Authors: Kriplani Priyanka , Guarve Kumar
Published: October 2021

Background:

Polymers are the backbone of modern pharmaceutical formulations and drug delivery technologies. Polymers that may be natural, synthetic, or semisynthetic are used to control the release of drugs in a pre-programmed fashion. The drug delivery systems are mainly prepared to enhance the bioavailability, site-specific release, sustained release, controlled release, i.e., to modify the release of drug from dosage form may be a tablet, capsule, etc.

Objective:

The objective of the present study is to overview the recent patents concerning the application of eudragit in the prevention of cancer and other ailments. Eudragit polymers are polymethacrylates and may be anionic, cationic, or non-ionic polymers of methacrylic acid, dimethylaminoethyl methacrylates, and methacrylic acid esters in varying ratios. Eudragit is available in various grades with solubilities at different pH, thus helping the formulators design the preparation to have a well-defined release pattern.

Method:

In this review, patent applications of eudragit in various drug delivery systems employed to cure mainly cancer are covered.

Results :

Eudragit has proved its potential as a polymer to control the release of drugs as coating polymer and formation of the matrix in various delivery systems. It can increase the bioavailability of the drug by site-specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs.

Conclusion:

The potential of eudragit to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.
Prevalence and Associated Factors of Common Mental Disorders Among Adult Residents in Silte Zone, Southern Ethiopia
Authors: Muze Mohammed , Denur Mehbub , Hussein Mubarek , Muzemil Mufta , Yesse Mubarek , Kedir Shemsu
Published: October 2021

Introduction:

Mental health problems appear to be increasing in importance in Africa. Mental and substance use disorders were the leading cause of yearly lived with disability in Sub-Saharan Africa. Evidence from previous studies shows considerable variation in the prevalence of these disorders. The most acceptable explanation for this wide variation is likely to be the fact that socio cultural factors are major determinants of mental disorders. Therefore a mental disorder has to be understood in a specific setting to develop effective and tailored interventions.

Objective:

The objective of this study was to determine the prevalence and associated factors of common mental disorders among adult residents in Silte Zone, southern Ethiopia

Methods:

Community based cross-sectional study was conducted in the study area. A total of 1178 adults were selected by using a three-stage systematic sampling technique. The Self-Reporting Questionnaire (SRQ-20) was used to determine the prevalence of common mental disorders. Data were analyzed by using SPSS version 20. Both bivariate and multiple logistic regression analyses were employed to identify factors associated with common mental disorders.

Results:

The prevalence of common mental disorders among adults found to be 39.7%. Increased age (OR = 1.114; 95% CI = 1.095, 1.134), being female (OR = 9.421; 95% CI = 5.947, 14.926), poor social support (OR = 1.987; 95% CI = 1.358, 2.907) and having life threatening experience (OR = 2.162; 95% CI = 1.825, 2.562) were significantly associated with common mental disorders.

Conclusion:

In the study, the magnitude of common mental disorders remains high in the study area. Increased age, being female, poor social support and having life-threatening experience were significantly associated with common mental disorders.
Anxiety Status and Coping Strategies in Association with Sociodemographic Factors, Dietary and Lifestyle Habits in Greece
Authors: Batsikoura Maria , Zyga Sofia , Tzavella Foteini , Sachlas Athanasios , Rojas Gil Andrea Paola
Published: October 2021

Aim:

The aim of this study was to investigate the relationship between nutritional habits, lifestyle, anxiety, and coping strategies.

Background:

Anxiety is an underestimated and often undiagnosed subclinical disorder that burdens the general public of modern societies and increases illness suscentibility.

Methods:

The study group consisted of 693 individuals living in Peloponnese, Greece. A standardized questionnaire that consists of the dietary habits and lifestyle questionnaire, the trait Anxiety STAI-X-2 questionnaire and the brief-COPE questionnaire, was used. Principal components analysis identified the factors from the questionnaires, and stepwise multivariate regression analysis investigated their relationships.

Results:

Weekly consumption of fruits, tomatoes, salads and lettuce, together with Εmotional/Ιnstrumental support, Denial/Behavioural disengagement, substance use and self-blame, was the most important predictors of anxiety scores. Positive reframing/Humour and Acceptance/Planning are also associated with the Positive STAI factor and decreased anxiety scores.

Conclusion:

Healthy nutritional habits, comprised of consumption of salads and fruits, together with adaptive coping strategies, such as Positive reframing/Humour and Active problem solving, may provide the most profound improvement in the anxiety levels of a healthy population in Peloponnese, Greece.
Learning and Use of eHealth Among Older Adults Living at Home in Rural and Nonrural Settings: Systematic Review
Authors: Airola Ella
Published: October 2021

Background

Care policies emphasize deinstitutionalization and aging in place in response to demographic changes. Different eHealth technologies are one way to achieve this aim. However, there is a need to better understand older adults’ needs for eHealth services, and thus, these health solutions require further exploration.

Objective

The purpose of this systematic literature review is to appraise, synthesize, and summarize the literature on older adults’ (aged ≥60 years) eHealth learning and use in real home settings, particularly in rural and remote areas, with a focus on the social and cultural context.

Methods

A systematic search was conducted in January 2020 using 4 academic databases. The studies by means of qualitative thematic analysis to identify the barriers, enablers, and support practices involved in the domestication process were examined. In addition, we identified the various meanings attached to eHealth technologies for older adults living in rural and remote areas.

Results

In total, 31 empirical studies published between 2010 and 2020 were included in this review. A total of 17 articles included participants from rural and remote areas. The most regularly reported barriers related to older adults’ learning to use and use of eHealth were health-related difficulties, such as cognitive impairment or impaired hearing. The most reported enabler was the support provided for older adults in learning and use of eHealth. Support mainly comprised older adults’ own digital competences, which were distributed with their social network. It was found that eHealth technology is needed for rural and remote areas to facilitate access and reduce logistical barriers to health care services.

Conclusions

The literature review provided information and practical implications for designers, health care providers, and policy makers. On the basis of these findings, eHealth technologies should be easy to use, and adequate support should be provided to older adults for use.
AMERICAN-MEXICAN BORDER CONFLICTS IN THE 1870–1910S
Authors:   Academician I.G. Petrovskii Bryansk State University (Russia), Prilutskiy V.V.
Published: October 2021

The article analyzes the border conflicts between Mexico and the United States at the turn of the XIXth and XXth centuries. American-Mexican relations were an important factor in the development of the regional subsystem of international relations in the Western Hemisphere. Historically, Mexico and the United States have had a complicated relationship. Mexico in the late XIXth – early XXth centuries was a secondary peripheral state, which was mainly agrarian in nature. There were both phases of acute confrontation (almost the entire XIXth century and the beginning of the XXth century), as well as periods of good neighborliness, relatively good, friendly, stable relationships and constructive cooperation. In relations with the United States at that time, it remained rather not a subject, but an object of influence. The extreme American expansionists proposed in the middle of the XIXth century to capture all of Mexico. In response to the aggressive aspirations of America, the Mexican radicals put forward their territorial claims to the neighboring country. They hoped to regain the vast northern region, that was lost during the wars of 1835-1848, which included Upper California, New Mexico, Utah, Arizona and Texas (which was called the "New Philippines" during the era of Spanish colonization). There are two stages of confrontation between the two countries: the 1870s – 1890s and the 1910s – 1920s. The most serious exacerbations on the border occurred in 1876, 1877, 1891-1893, 1896, 1906 and 1910-1919. Both government troops and irregular (militias, partisans, rebels) formations took part in the regional armed conflict. As a result, the situation stabilized for almost a century.
GREATER LONDON POLICE: ORIGINS AND CURRENT STATUS
Authors:   Lomonosov Moscow State University (Russia), Pronkin S.V.
Published: October 2021

The article is devoted to the interaction of the police and the elected bodies of Greater London-its Administration and municipal districts (boroughs) - in ensuring law and order. Both the history of the issue and its current state are touched upon. The foreign experience of interaction of the authorities in the maintenance of public security is of interest to the Russian Federation, which continues to search for effective forms of regional and municipal government, its place in the implementation of state functions. The experience of the United Kingdom is of particular interest in this regard, since in this country, the municipal and regional (self) government has historically developed significantly. The article mainly uses political and legal documents as sources of information. The author concludes that historically municipalities and local social forces played a crucial role in ensuring public security. It was typically for a «small state» with a tiny bureaucratic apparatus. Then government bodies played this role. Changes in the organization of the police were associated with the transition from the traditional rural society to modern urbanized. This required the creation of a professional centrally managed police force. The reform lasted for several decades. It’s important stage – Home office secretary R. Peel′s activity. Currently, efforts are being made to entrust the elected regional and municipal authorities with a new mission in ensuring public security – the exercise of democratic control over the activities of the police. In London this control is carried out by the mayor and the city council – Assembly. Municipal districts coordinate the activities of public services, civil, non-profit organization, business and individual citizens to ensure security in their territory.
THE ACTIVITIES OF THE SOVIET GOVERNMENT TO CLOSE ORTHODOX CHURCHES ON THE TERRITORY OF THE EASTERN TRANSBAIKALIA IN THE 1930S
Authors:   Transbaikal State University (Russia), Drobotushenko E.V.
Published: October 2021

The article describes the features of the Soviet government's activities in Eastern Transbaikalia to close Orthodox churches in the most difficult period of its Orthodox history – in the fourth decade of the XX century. It is noted that this time in the history of Orthodoxy in the region is poorly studied. The few available publications contain fragmentary data on the problem. This predetermined the appeal to the sources-the documents of the State Archive of the Russian Federation (SARF). On their basis, data on specific churches are provided, in some cases, the closure process is described, some communities of believers are mentioned, and the correspondence of believers with the OCAK containing complaints about the actions of local and regional authorities is characterized. The research is based on the principles of objectivity and historicism. The work is based on general scientific methods of collecting, analyzing and synthesizing material, as well as special methods of historical knowledge. It is noted that in the history of the closure of churches in Eastern Transbaikalia in the 1930s, there are controversial points that require clarification. In general, the data on the problem field of the article, to date, seems sketchy, which determines the need for further work with sources to clarify the available information and supplement the picture with new facts.
POSTHUMOUS CHRONICLE PRAISE OF THE RULER AS A HISTORICAL SOURCE
Authors:   Academician I.G. Petrovskii Bryansk State University (Russia), Ismailova Z.A.
Published: October 2021

This article is devoted to the study of such a separate historical and literary genre as the chronicle praise of the ruler. During the XI-XVI centuries, chronicle praise was a very common technique of medieval scribes. Comparing the praises of different Russian Chronicles and different historical periods, the author proves that the chronicle praise of the ruler grew out of a brief posthumous description of him, reflected the chronicler's good knowledge, his likes and dislikes, and in the XII century acquired a ready – made form-a literary form. Early praises (XI-XIII centuries) correctly reflected historical reality, contained individual traits of the ruler, changed depending on historical conditions, which increases their value as a historical source. It was also found out that there were two main forms of praise – southern and northern. The difference between them is that southern praise was secular, while northern praise was ecclesiastical; southern praise was limited to local interests, and northern praise had a world – historical scale. In general, praise can be considered as a separate chronicle of the medieval genre, characterized by special plot and stylistic features.
PERCEPÇÃO DOS IMPACTOS SOCIECONÔMICOS DO PORTO DO AÇU EM SÃO JOÃO DA BARRA, RIO DE JANEIRO
Authors: Monteiro Caroline Araújo , Profeta Graciela Aparecida , Ney Vanuza Da Silva Pereira , Rubinsztajn Igor Kippe
Published: October 2021

A instalação de grandes empreendimentos, de modo geral, mostra-se como propulsora do desenvolvimento socioeconômico das regiões receptoras uma vez que emprega substancial parcela de mão de obra, funcionando como fonte de renda para os cidadãos, comerciantes e para a administração pública. Nesse sentido, pretendeu-se verificar a percepção dos atores locais em relação aos impactos socioeconômicos da instalação do Complexo Industrial e Portuário do Açu em São João da Barra, Rio de Janeiro. Metodologicamente, utilizou-se da pesquisa bibliográfica para apresentar o histórico do referido Complexo, bem como realizar a comparação do mesmo com demais empreendimentos de infraestrutura localizados no Brasil no que se refere à percepção das transformações socioeconômicas; e, fez-se uso de entrevista semiestruturada para obter a percepção dos principais atores locais. Os resultados permitiram concluir que, de maneira geral, tanto os munícipes quanto os comerciantes revelaram uma percepção de que os impactos positivos, aumento do emprego, desenvolvimento socioeconômico e infraestrutura, superaram os impactos negativos, como o aumento da população, aumento do trânsito e as desapropriações. Já o gestor público se mostrou otimista com relação à qualidade de vida, aumento do emprego, infraestrutura, educação, saúde e desenvolvimento socioeconômico decorrentes da instalação do Complexo Industrial e Portuário do Açu. Essas percepções confrontadas com o referencial teórico sobre o desenvolvimento regional, podem indicar que os entrevistados deram maior importância para geração de emprego e renda, e ao mesmo tempo, minimizaram os aspectos como melhorias na qualidade de vida, educação, saúde, a violação dos direitos com as desapropriações e também os impactos ambientais.
O ENGAJAMENTO PÚBLICO ATRAVÉS DAS MÍDIAS SOCIAIS
Authors: De Melo Rochele Malheiros , Tontini Julia , Malheiros Michel Barboza , Rossato Vanessa Piovesan , Wegner Roger Da Silva
Published: October 2021

O uso da tecnologia é uma realidade constante na vida da população. Suas diversas ferramentas possibilitam uma nova forma de relação e comunicação. As mídias sociais como o Facebook e o Instagram estão cada vez mais sendo utilizadas pelo setor público visando uma maior interação com a população. Dessa forma, com o objetivo de analisar o uso das mídias sociais como ferramenta de engajamento público por meio da utilização das mídias sociais de uma Prefeitura do Rio Grande do Sul, realizou-se um estudo caracterizado como descritivo, de natureza aplicada e abordagem quantitativa. A coleta de dados contou com a aplicação de um questionário online enviado através do Facebook, totalizando 114 habitantes do município que forneceram sua percepção. Os resultados indicam que a população não utiliza as mídias sociais como forma de interação com a Prefeitura, uma vez que os respondentes relataram não reagir as publicações da Prefeitura. Além disso, observou-se que as publicações da Prefeitura visam apenas informar a população, sendo essa a principal finalidade de acesso. Dessa maneira, este estudo favorece a compreensão da Prefeitura estudada quanto a sua interação com a população por meio das mídias sociais, facilitando a tomada de decisão e criação de estratégias para que as mídias sociais, além de ser um meio de informação, tornem-se um espaço de interação com o público.
ESTUDO VARIACIONISTA DA REDUÇÃO DA PREPOSIÇÃO PARA EM MACEIÓ/AL
Authors: Almeida René Alain Santana de , Oliveira Alan Jardel de
Published: October 2021

Este artigo objetiva observar de que forma se processa a variação da preposição para em suas variantes [para], [pra] e [pa], no falar de Maceió, em função da influência de fatores sociais e linguísticos. Nesta pesquisa, o corpus foi coletado com trinta informantes. Foram testadas as seguintes variáveis independentes: contexto fonológico seguinte, paralelismo, acento da sílaba seguinte, classe da palavra seguinte, presença de tepe no item seguinte, faixa etária e sexo. As gravações coletadas foram anotadas no ELAN e a análise multivariacional dos dados realizada com o programa Goldvarb, que não considerou como estatisticamente significativa a interferência das variáveis paralelismo e classe morfológica da palavra seguinte na variação estudada. Do corpus coletado, verificamos um número inexpressivo (menos de 1%) de ocorrências da variante para. Os contextos favoráveis à forma inovadora pa foram: i) as consoantes coronais e as vogais posteriores; ii) a presença de tepe na sílaba seguinte; e iii) a ausência de acento na sílaba seguinte. Além disso, constatamos que os mais jovens e as mulheres produzem mais a variante [pra]. Esses resultados apontam para o desaparecimento da variante [para] na fala dos maceioenses.
USO DE ABREVIATURAS EM UM LIVRO DE ASSENTOS DE CASAMENTOS DO SÉCULO XVIII DO SERTÃO DE BAIXO DO RIO SÃO FRANCISCO
Authors: Barbosa de Assis Lécio , Alves da Silva Jorge Augusto , Pacheco Vera
Published: October 2021

O presente estudo aborda o uso de abreviaturas no Livro n.º 1 dos assentos de casamentos da Freguesia de Santo Antônio do Urubu de baixo do Rio São Francisco (1719-1753), exarado por oito diferentes scriptores ao longo do recorte temporal estudado. Este trabalho apresentará uma breve descrição codicológica, bem como o levantamento da frequência do uso das abreviaturas, com o objetivo de revelar as tendências utilizadas na época em que o manuscrito foi produzido, como também, as peculiaridades de cada scriptor. Metodologicamente, para empreender este estudo, realizamos a (i) exploração das particularidades do suporte material do documento; (ii) leitura e transcrição a partir da reprodução fac-similar; (iii) sistematização do número de ocorrências e comparação das frequências de acordo com o sistema de classificação das abreviaturas com o auxílio da ferramenta computacional aplicada à Terminologia AntConc (2011) e (iv) reflexão filológico-paleográfica das abreviaturas e dos sinais de abreviações. Por meio do referencial teórico, buscamos trilhar os caminhos filológicos e paleográficos, recorrendo às obras de Bluteau (1728), Vieira (1871), Spina (1977), Acioli (1994), Núñez Contreras (1994), Cambraia (2005), Berwanger e Leal (2008) e Flexor (2008). Os resultados evidenciaram que o uso das abreviaturas, no documento analisado, seguia as tendências gerais da época, transmitidas pela tradição documental, embora as Constituições Primeiras do Arcebispado da Bahia (1719) orientavam que os registros paroquiais deveriam ser exarados por extenso para evitar enganos e dificuldades na leitura.
From face-to-face to virtual teams: work organization during the Covid-19 pandemic
Authors: Carozzo-Todaro Mauro Enrique , Pinheiro-Carozzo Nádia Prazeres , De Souza Machado Andreza
Published: October 2021

Context: Work teams in the Human Resources and Financial Department of a large consumer goods company needed to reorganize and adapt themselves to the compulsory remote work imposed by the Covid-19 pandemic. Through daily online meetings, they interacted, learned to deal with the new scenario, perceived difficulties, and found opportunities. Now, they are facing uncertainty about to what extent this work organization will be maintained in the medium-  and long-term. Teaching goals: Analyze the characteristics of the work-teams, reflect on the factors that facilitated and hindered the performance of virtual teams, and assess the challenges faced by the virtual teams created on a compulsory basis. The case generates reflection about face-to-face and virtual teamwork, as well as on barriers, facilitators, and challenges for the implementation of remote work, which enables fostering competencies and skills of recognition, definition, and resolution of problems, strategic thinking, and proposals for changes in work organization. As it presents different contexts and opinions, sometimes contradictories, careful referrals are required. Data source: The case is based on real data obtained through an electronic questionnaire sent to employees in June 2020. The name of the company was kept confidential. Although real speeches, characters, and their interaction are fictional. Applicability: It can be used as a teaching tool in modules related to Human Resource Management, Organizational Behavior, and Team Development, present in postgraduate courses. Teaching notes establish educational objectives, recommended use of the case, lesson planning, and guiding questions for discussion in class.
Keywords: teaching case; teamwork; virtual teams; organizational behavior; Covid-19
Dupilumab Provides Rapid and Sustained Clinically Meaningful Responses in Adults with Moderate-to-severe Atopic Dermatitis
Authors: Silverberg Jonathan I. , Simpson Eric L. , Boguniewicz Mark , De Bruin-Weller Marjolein S. , Foley Peter , Kataoka Yoko , Bégo-Le-Bagousse Gaëlle , Chen Zhen , Shumel Brad , Chao Jingdong , Rossi Ana B.
Published: October 2021

Optimal management of atopic dermatitis requires a comprehensive assessment of response to treatment in order to inform therapeutic decisions. In a real-world setting, successful response to atopic dermatitis treatment is measured by sustained improvements in signs, symptoms, and quality of life. Post-hoc analyses of a 1-year, randomized, double-blinded, placebo- controlled trial (NCT02260986) of dupilumab with concomitant topical corticosteroids in 421 adults with moderate-to-severe atopic dermatitis (of whom 315/106 received placebo/dupilumab (of whom 315 received placebo and 106 received dupilumab) was performed to assess the proportion of responders to dupilumab through a multidimensional composite endpoint. At 6-months, 80.2% of dupilumab-treated vs 40.0% placebo patients (p < 0.0001) achieved improvement in signs (Eczema Area and Severity Index ≤ 7), symptoms (worst itch score ≤ 4), or quality of life (Dermatology Life Quality Index ≤5), representative of minimal/clear atopic dermatitis. All 3 endpoints, indicative of no/minimal atopic dermatitis, were achieved by 44.3% of dupilumab-treated vs 10.2% placebo patients (p < 0.0001) and sustained through 1 year. Dupilumab treatment provided sustained clinically meaningful improvement in signs, symptoms, and quality of life in adults with moderate-to-severe atopic dermatitis.
The Importance of Assessing Burning and Stinging when Managing Rosacea: A Review
Authors: Schaller Martin , Dirschka Thomas , Lonne-Rahm Sol-Britt , Micali Giuseppe , Stein Gold Linda F. , Tan Jerry , Del Rosso James
Published: October 2021

Rosacea, a chronic condition usually recognized by its visible presentation, can be accompanied by invisible symptoms, such as burning and stinging. The aim of this review is to gather the most recent evidence on burning and stinging, in order to further emphasize the need to address these symptoms. Inflammatory pathways can explain both the signs and symptoms of rosacea, but available treatments are still evaluated primarily on their ability to treat visible signs. Recent evidence also highlights the adverse impact of symptoms, particularly burning and stinging, on quality of life. Despite an increasing understanding of symptoms and their impact, the management of burning and stinging as part of rosacea treatment has not been widely investigated. Clinicians often underestimate the impact of these symptoms and do not routinely include them as part of management. Available therapies for rosacea have the potential to treat beyond signs, and improve burning and stinging symptoms in parallel. Further investigation is needed to better understand these benefits and to optimize the management of rosacea.
Diseño de una Planta Piloto para Extracción de Metabolitos Naturales (Antioxidantes) a Partir de Tomate Chonto
Authors: Ocampo Trujillo Cristian Antonio , Vargas Giraldo Diana Carolina , Pérez Barrera Luis Ernesto
Published: October 2021

En el presente trabajo se realizó una comparación a partir de la revisión teórica y una simulación en el programa súper pro designer, de dos métodos para la extracción de metabolitos, para el diseño de una planta piloto. Los métodos comparados fueron la extracción con disolventes orgánicos y la extracción por fluidos supercríticos. Según lo encontrado en el estado del arte para ambos métodos se decidió tomar como referente la extracción por fluidos supercríticos con CO2 para la extracción de licopeno del tomate chonto en vista de las ventajas en el proceso respecto al método de extracción con solventes orgánico. Teóricamente se plantean extracciones del 85 % al 95 % de pureza dato de partida para la simulación realizada en el presente trabajo.

Según las simulaciones para los métodos tratados, los tiempos de extracción utilizados fueron de 180 a 360 minutos. Con el método de fluidos supercríticos el tiempo puede disminuir a los 180 minutos pues se observa que se reduce drásticamente la cantidad de sustancia extraída. Definido el método de extracción del licopeno se realizó el análisis de factores que determinaron los criterios para el diseño de la planta piloto, incluyendo los costos, planos y líneas de producción.
Educación Interprofesional, fundamentos y estrategias didácticas: revisión del estado del arte
Authors: Dueñas Darzón Adriana Lucía , Leguizamón Rojas Diana Stephanie , Upegui Castillo Andrés Alejandro
Published: October 2021

La Educación Interprofesional - EIP - se presenta como una necesidad del sector salud y de las instituciones formadoras, como un imperativo centrado en el paciente, familia y comunidad, lo que incidirá en la calidad de la atención y disminución de los eventos adversos. El objetivo de la revisión es conocer como la EIP ha generado interés en producción bibliográfica. Se establecen términos de referencia, antecedentes, ventajas, dificultades y limitantes, así como las estrategias didácticas más frecuentemente referenciadas en su implementación y el desafío para su integración desde el nivel técnico.
The importance of translation in interlingual relations
Authors: Jafarova Kamala Avadır
Published: October 2021

The language, culture and literature of any nation become strong when it has a great translation literature. That nation has a strong culture and literature because it translates the spiritual and cultural achievements of other nations into its native language and benefits from them. Rather, any language that translates world literature regardless of their size creates and enriches the spiritual bridge of language relations. From this point of view, the Azerbaijani language is no exception.  The article consists of three parts. The first part deals with the history of inter-linguistic relations, mainly English and Azerbaijani language relations. The second part of the article discusses the history of literary translation in Azerbaijan.   Finally, important part of the translation into and from the Azerbaijani language, are reviewed and analyzed.  The article concludes by making the point that literary translation is a spiritual bridge that connects different languages and cultures, translators are bridge builders.
Perfiles jurisprudenciales de la protección a los terceros adquirentes de viviendas mediante compraventa en Cuba
Authors: Guzmán Suset Hernández
Published: October 2021

El artículo muestra un acercamiento a la realidad cubana en torno a la protección a los terceros adquirentes de viviendas obtenidas mediante contrato de compraventa entre personas naturales, en atención a las sentencias dictadas por el Tribunal Supremo Popular con posterioridad a 2011. Las severas limitaciones impuestas a la autonomía privada en relación con este contrato en particular desde los primeros años de la Revolución, unido al sensible desmantelamiento del Registro de la Propiedad regido por la Ley Hipotecaria de 1893, determinan la desaparición de estos sujetos del escenario jurídico hasta que se produce la flexibilización del tráfico inmobiliario del país en el año indicado, con la puesta en vigor del Decreto Ley Núm. 288, modificativo de la Ley General de la Vivienda. Por ello, se valoran las soluciones ofrecidas por la máxima judicatura cubana a fin de identificar un posible perfil jurisprudencial de los terceros adquirentes y proponer pautas de actuación jurisdiccional que guíen el camino hacia su efectiva protección en el corto plazo.
Determining the role of natural SARS-CoV-2 infection in the death of domestic pets: 10 cases (2020–2021)
Authors: Carpenter Ann , Ghai Ria R. , Gary Joy , Ritter Jana M. , Carvallo Francisco R. , Diel Diego G. , Martins Mathias , Murphy Julia , Schroeder Betsy , Brightbill Kevin , Tewari Deepanker , Boger Lore , Gabel Julie , Cobb Robert , Hennebelle Janemarie , Stanton James B. , McCullough Kathryn , Mosley Yung-Yi C. , Naikare Hemant K. , Radcliffe Rachel , Parr Boyd , Balsamo Gary , Robbins Brent , Smith David , Slavinski Sally , Williams Carl , Meckes Doug , Jones Dee , Frazier Tony , Steury Kelley , Rooney Jane , Torchetti Mia , Wendling Natalie , Currie Dustin , Behravesh Casey Barton , Wallace Ryan M.
Published: October 2021

OBJECTIVE

To establish a pathoepidemiological model to evaluate the role of SARS-CoV-2 infection in the first 10 companion animals that died while infected with SARS-CoV-2 in the US.

ANIMALS

10 cats and dogs that tested positive for SARS-CoV-2 and died or were euthanized in the US between March 2020 and January 2021.

PROCEDURES

A standardized algorithm was developed to direct case investigations, determine the necessity of certain diagnostic procedures, and evaluate the role, if any, that SARS-CoV-2 infection played in the animals’ course of disease and death. Using clinical and diagnostic information collected by state animal health officials, state public health veterinarians, and other state and local partners, this algorithm was applied to each animal case.

RESULTS

SARS-CoV-2 was an incidental finding in 8 animals, was suspected to have contributed to the severity of clinical signs leading to euthanasia in 1 dog, and was the primary reason for death for 1 cat.

CONCLUSIONS AND CLINICAL RELEVANCE

This report provides the global community with a standardized process for directing case investigations, determining the necessity of certain diagnostic procedures, and determining the clinical significance of SARS-CoV-2 infections in animals with fatal outcomes and provides evidence that SARS-CoV-2 can, in rare circumstances, cause or contribute to death in pets.
Treatment of shoulder joint luxation with glenoid ostectomy in a miniature donkey
Authors: Skelton Jase A. , Hawkins Jan F. , Rochat Mark C.
Published: October 2021

CASE DESCRIPTION

A 13-year-old 128-kg miniature donkey gelding was evaluated for right forelimb lameness of 7 weeks’ duration.

CLINICAL FINDINGS

Muscular atrophy of the infraspinatus and supraspinatus muscles over the right scapula with a palpable bony prominence over the point of the shoulder was evident. At the walk, the cranial phase of the stride was reduced with adduction of the distal aspect of the limb, dragging of the toe, and lameness (grade, 4/5). Lateral and craniocaudal radiographs of the right shoulder joint revealed lateral luxation of the humerus in relation to the scapula with bony proliferation and remodeling of the humeral head.

TREATMENT AND OUTCOME

Glenoid ostectomy was performed. Immediately after surgery, the donkey was able to intermittently stand squarely on the limb but maintained a reduced cranial phase of the stride at the walk. The donkey had no short-term complications and was discharged from the hospital 11 days after surgery. Following discharge, the donkey was confined to a box stall for 60 days, followed by a gradual increase in movement to full pasture turnout. The lameness continued to improve, and at 15 months after surgery the donkey was turned out in pasture and had mild lameness (grade, 3/5) at the trot. Mild muscular atrophy of the supraspinatus and infraspinatus muscles was present with no signs of pain on palpation or manipulation of the limb. Shoulder joint radiography at 15 months after surgery revealed remodeling of the glenoid cavity of the scapula and humeral head with formation of a pseudoarthrosis.

CLINICAL RELEVANCE

Glenoid ostectomy should be considered as an alternative to shoulder joint arthrodesis in small equids with shoulder joint luxation. Other indications for this procedure could include chronic osteoarthritis or fractures affecting the shoulder joint.