bluuebunny/crossref_metadata_2025 huggingface dataset:
MOLECULAR DOCKING STUDY: TARGETING SICKLE CELL ANEMIA USING ACTIVE PHYTOCHEMICAL COMPOUNDS FROM ZANTHOXYLUM ZANTHOXYLOIDES
Authors: DAS MOULI
Published: August 2023

Objectives: A category of genetic disease which is sickle cell disease is called sickle cell anemia. In this, the red blood cells are affected in shape and structure, which normally carries oxygen to every part of our body. Therefore, by using molecular docking studies, Absorption, Distribution, Metabolism, and Excretion (ADME) analysis for phytocompounds, an effort was made to find natural compounds from a plant named Zanthoxylum zanthoxyloides, which has many medicinal properties in Indian Ayurveda, to prevent this genetic disease.
Methods: The Protein Data Bank database was used to retrieve the primary protein, hemoglobin. The PyRx tool was used to perform docking because the ligands were poorly binding with the compounds and were interfering with the docking, so this tool was used. Swiss-ADME and the Admetlab web server were used for the analysis of ADME and drug similarity.
Results: Five chemicals from Z. zanthoxyloides have been identified through molecular docking investigations as having high binding affinity to the protein by inhibiting the replication of viruses and proteolytic cleavage. Out of these five compounds, Benz[c]acridine, Fagaramide trans-fagaramide was safe and possessed drug-like qualities according to the ADMET profile and drug similarity prediction.
Conclusion: According to the current study, Benz[c]acridine and Fagaramide trans-fagaramide have a particular binding affinity and aid in the management of treatment approaches for treating sickle cell anemia.
DECIPHERING GENDER DISPARITIES IN SOCIOECONOMIC CUM CULTURAL, AND RELIGIOUS PRACTICES IN AFRICA
Authors: ODUSANYA TEMITOPE OMOTOLA , Fayomi Oluyemi Oyenike , Ogunsanwo Alaba
Published: August 2023

Demographically, more than half of the African population are women. Nevertheless, disparities in allusion to gender lingers at the apex of contemporary issues, especially in Africa. For several decades, women have been longstanding and continuously sidelined from the socioeconomic, cultural, and religious leadership positions and participation. Gender disparities, therefore, seem to be deeply embedded in socioeconomic, cultural, and religious practices in Africa. Despite the multifarious national and international legislations endorsed against gender disparities, there remains a great lacuna of women’s marginalization in governance. The study illuminated the gender disparities with the aid of historical and analytical evaluation as well as the social role theoretical framework. This was further combined with the explanatory and exploratory qualitative research design. This was effective in understanding the numerous drivers for gender disparities as well as the social gender roles and norms, the general exploitative nature of marriage, cultural legacies, politics, and religion in the African context vis a vis western world. This paper also discovered that although women are as intellectually capable as men, ostracism of women remains evident across diverse echelons of human civilization including democratic societies. The research found that some critical factors such as economic impediments, lack of or inadequate education, and religious belief, foster gender disparities in Africa. This research recommended an overhaul of the patriarchal education and curriculum, the analysis and study of religious books must be in accordance with the transformed sociological realities. Moreover, equality must be evidenced in the recruitment process of qualified men and women in governance. The paper concluded that the inflexible and barbaric cultural stereotypes and religious practices be reformed with consideration to gender parity. A standard shift is essential especially by women themselves, to ensure that women are both enlightened and empowered.
PROBLEMS ARISE IN CHECKING THE CERTIFICATE ELECTRONICALLY IN THE PROCESS OF TRANSITIONING LAND RIGHTS AND SOLUTIONS
Authors: ARISTIAWATI AYU KARISA FANIA , FIRDAUS SUNNY UMMUL , SOLIKHAH
Published: August 2023

Regulation of the Minister of Agrarian Affairs/Head of the National Land Agency Number 16 of 2021 Third Amendment to the Regulation of the Minister of Agrarian Affairs/Head of the National Land Agency Number 3 of 1997 concerning Provisions for Implementing Government Regulation Number 24 of 1997 concerning Land Registration which requires checking certificates carried out entirely by electronic means by the Land Deed Making Officer (PPAT) but in practice, there are still many obstacles that must be faced by PPAT for the electronic certificate checking. This paper aims to describe various problems with electronic certificate checking by PPAT as well as solutions to all problems that occur in providing legal land guarantees and certainty and information disclosure in the community. The method used in this research is normative research using secondary data in the form of primary legal material in the form of legislation. The technique used in legal materials collection is a literature review or documentation using legal material analysis techniques as well as the deductive method. The results of this study put forward the problems that occur in checking electronic certificates, among others, physical certificates received by PPAT for checking cannot be ascertained whether or not valid, there is a discrepancy of data on the certificate checking results, the certificate data are not suitable for the land book data in the office of the National Land Agency (BPN), causing doubts and obstructing the transferring process of rights. The results of this study also offer a number of solutions that can be considered, among others: PPAT must carefully ensure the suitability of the existing data on the physical certificate or the data of results of electronic certificate checking, BPN is actively updating database system that adheres to the principle of liability, and it is expected that the BPN can minimize the error in recording juridical and physical data in the future. In the end, checking the certificate is a very effective step against the prevention of land disputes in the process of land transition and also reduces cases of land mafia in Indonesia. This will also be realized if supported by all parties both from PPAT, the community and BPN. The role of BPN is very necessary for this step, especially in the rule of the letters archived in BPN synchronized correctly when checking the certificate electronically.
High Secure Data Transactions in AXI System Bus using Firewall Protection
Authors: D Pruthvi , P Dr. Srividya
Published: August 2023

Abstract: An open-standard, on the chip interconnection protocol called the Advance Microcontroller Bus Architecture (AMBA) is used to link and manage functional blocks in systems on chip (SoC) architectures. An interface definition called Advanced eXtensible Interface (AXI) specifies the IP block interface rather than the connection itself. The point-to-point connections between a supervisor as well as subordinate are defined by the AXI protocol in terms of their signals and time. The existing AXI protocol only has the response mechanism for the slave error and the valid transactions. In this work the high secure data transactions in AXI system bus is introduced using the firewall protection where a certain range of address are protected to access from other master peripherials
Credit Card Fraud Detection Using Machine Learning: A Review
Authors: . Mehvish , Saini Satish , Singh Ravinder Pal
Published: August 2023

Abstract: Emerging technology has brought about transformative changes across various vital industries such as healthcare, finance, manufacturing, transportation, and e-commerce. Among these sectors, the financial industry, in particular, has experienced significant positive shifts due to technological advancements. Banking services have embraced digitization and the evolution of e-commerce, resulting in a notable growth in the utilization of credit cards. However, with these advancements comes a challenge: an increase in fraudulent activities. This challenge has prompted the financial industry to take proactive measures to ensure the security and effectiveness of its operations. The surge in credit card usage has unfortunately attracted a higher number of fraudulent actors, leading to several predicaments for the banking sector. Amidst these challenges, financial institutions are committed to safeguarding credit card transactions and providing secure e-banking services to their clients. To address this, they are actively engaged in the development of more sophisticated fraud detection techniques. These techniques aim to not only identify a broader range of fraudulent transactions but also to enhance the overall effectiveness of fraud prevention systems and fraud detection systems. This article aims to provide a comprehensive overview of the key elements that constitute effective fraud detection, along with a deep dive into the current systems and methodologies in place. By shedding light on the prevalent challenges and complexities associated with fraudulent activities in the banking industry, the article also underscores the vital role that machine learning techniques play in the realm of solutions. In essence, this article seeks to showcase the positive trajectory of the financial industry's response to emerging challenges, highlighting its commitment to leveraging cutting-edge technology to ensure secure and seamless banking experiences for all clients
Achieving Equal Protection for Children in Scotland: A Narrative Account
Authors: Barrett Joanna
Published: August 2023

In 2019, the Scottish Parliament passed a Bill that repealed the ‘reasonable chastisement’ defence in Scotland. This article provides a narrative account of this momentous reform.  It describes the history of Scotland’s law and gives an overview of a civil society campaign, coordinated by children’s organisations, to secure legal reform. It provides reflections on the campaign, setting out key learning points, including the importance of language and framing; the use of evidence; and the strength of broad coalitions. This account is offered to help inform similar campaigns to provide all children with protection from physical harm.
Introduction to the Special Issue
Authors: Durrant Joan
Published: August 2023

One of Britian's colonial legacies is the common law defence available to adults who corporally punish children. Canada inherited this defence, which became codified in 1892 as Section 43 of the Criminal Code. The aim of this Special Issue is to examine Canada's law alongside those of other former members of the British Empire that have abolished their defences - Ireland, Scotland and Wales.

The first three papers in this issue will place Canada's law within its global, historical and colonial contexts.  The next three papers tell the stories of how Ireland, Scotland and Wales overcame the same challenges faced in Canada to ultimately provide equal protection for children.
Interseccionalidad y el caso de los Empleados de la fábrica de fuegos de Santo Antônio de Jesus y sus familiares vs. Brasil: un análisis jurisprudencial
Authors: Dias Oliveira Samuel Lucas
Published: August 2023

Este análisis jurisprudencial tiene como objetivo verificar si el uso de discriminación interseccional realizado por la Corte Interamericana de Derechos Humanos en el caso Empleados de la fábrica de fuegos de Santo Antônio de Jesus y sus familiares vs. Brasil está en consonancia con la jurisprudencia internacional y los estándares desarrollados por otros tribunales regionales de derechos humanos. Se eligió este caso por la multiplicidad de identidades de las personas implicadas, la dimensión estructural de las violaciones de derechos humanos y las complejas observaciones actuadas por la Corte IDH sobre la confluencia de la discriminación interseccional y estructural. Se utilizaron fuentes bibliográficas primarias —casos juzgados por los tribunales— y secundarias —libros, artículos y publicaciones periódicas— para rastrear los conceptos, investigar sobre discriminación y violaciones de derechos humanos y comprender las sentencias dictadas por los tribunales regionales. Los casos usados para el análisis de la jurisprudencia del Tribunal Europeo de Derechos Humanos se eligieron sobre la base de la propia selección de “casos clave” del órgano en relación con la interseccionalidad; mientras que los casos del Tribunal Africano de Derechos Humanos y de los Pueblos fueron aportados por investigadores de renombre en la materia.
Cali: tierras, transacciones y agentes, 1770-1810
Authors: Orozco Álvarez Álvaro Alejandro
Published: August 2023

Este libro analiza el mercado de la propiedad de la tierra rural en la jurisdicción de Santiago de Cali entre 1770 y 1810. Se examina el funcionamiento del mercado de la propiedad, destacando las características de los agentes involucrados en las transacciones. El análisis de los protocolos notariales revela la construcción jurídica y la circulación del dominio absoluto sobre esta. La potestad de carácter privado fue otorgada como privilegio por la Corona española a los primeros conquistadores del territorio. Este sistema de privilegios permitió privatizar la posesión y generó un mercado que dio lugar al acceso a la tierra mediante la compra legalizada en las escribanías públicas. Las escrituras de compraventa se convirtieron en un instrumento de análisis económico, político y simbólico. Por un lado, revelan la dinámica económica de la circulación del dominio absoluto sobre la tierra; por otro lado, los actos simbólicos de las escrituras construyen la propiedad legítima ante la escribanía pública, una institución regida por las tradiciones del derecho castellano. La legitimidad de las transacciones estaba respaldada por la gracia real y se firmaban escrituras con normas claras y estandarizadas para cada caso de traspaso de privilegio del dominio.
Prácticas pedagógicas que contribuyen a la construcción de una mejor ciudadanía
Authors: Giraldo Gómez Olga , Zuluaga Giraldo Jorge Iván , Jaramillo Echeverry Alberto , Vargas Aguirre Jhon Fredy
Published: August 2023

La Universidad Católica de Manizales en coherencia con su compromiso social, desde la Facultad de Educación se acoge y aporta al objetivo de la Fundación Niños de los Andes, en términos de brindar apoyo en el mejoramiento de la calidad de vida de los niños, niñas y jóvenes de la Fundación, reconociéndolos como sujetos de derecho; aportando a la base desde un ejercicio colaborativo de los estudiantes y docentes de los programas de licenciatura, a través del apoyo pedagógico en las áreas de lengua castellana, inglés y tecnología e informática. Dicho ejercicio se ejecuta a través de diversos momentos, articulados a las prácticas pedagógicas de cada uno de los programas, vislumbrando nuevas estrategias de acompañamiento con alto sentido social. Es por ello que se logró fortalecer a la población, en el uso apropiado del inglés como segunda lengua, la posibilidad de interacción desde diversas estrategias en el área de tecnología en informática desde talleres de sensibilización con desarrollos tecnológicos y, en especial, el mejoramiento de los procesos lecto-escriturales como fundamento del proceso académico.
Efectos del desabastecimiento de agua potable en empresas turísticas. El caso de Santa Marta (Colombia)
Authors: Vargas-Leira Freddy de Jesús , Navarro Hernández Pedro Luis , Sossa Álvarez Rubén Darío
Published: August 2023

Este trabajo tuvo como objetivo analizar los efectos ocasionados por el desabastecimiento o insuficiencia en el suministro de agua potable en la actividad turística de un territorio costero, tomando como caso de estudio a las empresas dedicadas a actividades de alojamiento y de expendio de alimentos y bebidas en la ciudad de Santa Marta, Colombia, durante el año 2021. El método utilizado tuvo enfoque mixto y alcance descriptivo, mientras que los instrumentos implementados consistieron en la recolección de información empírica a través de la aplicación de cuestionarios a una muestra representativa de los actores involucrados, así como la triangulación de los datos con fuentes teóricas obtenidas por medio de revisión documental. Los resultados mostraron, por un lado, que las causas de esta problemática se relacionan principalmente con la falta de inversión estatal, así como con la existencia de conexiones fraudulentas a los canales de suministro de agua; mientras que, entre los efectos económicos más significativos, se destaca el incremento de los costos de operación para las empresas turísticas hasta en un 40%, representados en la adquisición de agua a vehículos tipo cisterna o ‘carrotanques’ y compra de equipos de bombeo. Igualmente, este estudio concluye que la problemática descrita coloca al territorio analizado en una condición de vulnerabilidad mayor ante las consecuencias generadas por el cambio climático y el calentamiento global, en el que las sequías agravan el problema de disponibilidad del recurso hídrico. Además, resulta interesante el hecho de que las consecuencias del desabastecimiento de agua en los turistas fuesen menos significativas de lo que se esperaba al inicio de la investigación, lo que se suma a la ausencia de posiciones autocríticas identificadas en los representantes de las empresas turísticas en cuanto a su responsabilidad para atender o mitigar esta problemática.
Review of Islamic Branding in Building Islamic Financial Literacy and Religious Behavior on Sharia Financing Preferences (Study on Employees of Pandu Holding Company)
Authors: Yulianto Agus , Siswati Indra
Published: August 2023

Study this aim for know the effect of of islamic financial literacy and religious behavior on islamic financing preferences with islamic branding as a mediation variable. The method in this study uses primary data collected using online questionnaires through the Google form and distributed by distributing Google links to respondents to Pandu Holding Company (PHC) employees . The sampling technique used simple random sampling technique with a quantity of 30 respondents. The data analysis technique used in this study is using Structural Equation Modeling (SEM) version 3.0. The first stage, testing the validity of the questions from each variable along with its reliability. In the second stage, testing the causality of financial literacy and religious behavior towards sharia financing preferences with Islamic branding as a mediating variable. The results of this study indicate that the variables of Islamic financial literacy and religious behavior have a positive and significant effect on Islamic financing preferences through Islamic branding.
Analysis of Factors Affecting Fintech Consumers in Indonesia
Authors: Hafiz Gilang Pratama , Atmaja Dodi Ria , Tamzil Fachmi
Published: August 2023

The researcher conducted a pre-survey in order to find out more about the reasons that make consumers choose digital payment providers in making daily payments. From the pre-survey that was asked of 100 consumers, it was found that there were 4 factors that dominated the determination of consumer intentions in choosing digital payment providers. Based on the situation analysis and pre-survey findings, it is important to conduct this research so that it can become a strong theoretical foundation for stakeholders in the financial technology industry (FINTECH) in Indonesia and can contribute to the success of government programs in encouraging the development of the digital economy and digitalization in Indonesia. The sample involved 1,713 respondents with certain criteria and was analyzed using the structural equation modeling method. The findings state that the intention to use FINTECH can be increased through user satisfaction. Customer satisfaction is strongly influenced by the diffusion of innovation from the technology presented in the service, where the service must be able to make it easier for users to transact. Customer satisfaction must be a priority in designing customer-oriented product and service management, so as to form brand integrity that reflects quality service. To obtain a better determination, especially in assessing customer satisfaction using mobile payments, many factors such as Hedonic Value, Information Quality are factors that are suspected to have antecedents that need to be tested.
The Role of Job Satisfaction in Mediating the Influence of Occupational Health & Safety (K3) and Work Environment on Employee Performance at PT. Margaria Group Yogyakarta.
Authors: Utari Febby Tri , Subyantoro Arief
Published: August 2023

The type of research that researchers conducted was quantitative research which aimed to determine the effect of Occupational Health & Safety and Work Environment on Employee Performance with Job Satisfaction as a mediating variable. The sample used in this study were general affairs employees at PT. Margaria Group Yogyakarta with 50 employees. The sampling technique was carried out using non-probability sampling with saturated sampling method. Data collection was carried out using a questionnaire. The analysis technique used in this research is path analysis. The results of this study conclude that Occupational Health & Safety has a positive and significant effect on Employee Performance and the Work Environment has a positive and significant effect on Employee Performance. Occupational Health & Safety and Work Environment have a significant effect on Employee Performance indirectly through Job Satisfaction as a mediating variable.
The Influence of Brand Image and Promotion On Product Purchasing Decisions at PT. Gaya Motor Branch Tarok Dipo Bukittinggi City
Authors: Mita Mita , Doni Amsah Hendri
Published: August 2023

This study aims to determine and analyze the effect of brand image and promotion on product purchasing decisions at PT. Taxi Motorcycle Style. City of Tarok Dipo Bukittinggi. The type of research that the authors conducted was field research using a quantitative approach. The data used in this study were visitor data at PT. Style Motor Cab.Tarok Dipo Bukittinggi City 2017-2021 period (per year). This study used the SPSS (statistical package for social science) 26 program to process the data.   The results showed that partially brand image has a value of 0.00 less than 0.05 or (0.00 <0.05) thus it can be concluded that the brand image variable partially influences purchasing decisions, promotion is 0.868 greater than 0 .05 or (0.868 > 0.05) so that it can be concluded that the promotion variable does not affect the decision partially. Simultaneously brand image and promotion have F count > F table or 17.681 > 3.093. Thus it can be concluded that brand image and promotion have a significant effect on purchasing decisions.
Comparative Analysis of Financial Performance of BUKU 4 Conventional Banks Before and During Covid-19 Pandemic
Authors: Wijayanti Mayuna Farah , Hikmah Khoirul
Published: August 2023

Banks in Indonesia are facing a number of challenges amid the Covid-19 Pandemic. Banks will face several possible risks to financial performance. This study aims to determine the level of banking financial performance, especially in BUKU 4 Conventional Banks before and during the Covid-19 Pandemic for the 2019-2020 period using RGEC analysis (Risk Profile, Good Corporate Governance, Earnings, and Capital). The data used is secondary data obtained from the financial statements of banks included in the BUKU 4 category and processed using SPSS version 25. The results of the research on the financial performance of BUKU 4 Conventional Banks which can be seen from the Differential Test table (Paired Sample T-test and Wilcoxon test) show a decrease in several factors such as Risk profile and earnings factors. Meanwhile, the GCG and Capital factors show stable results both before and during the Covid-19 Pandemic
Wong Phui Nam (1935-2022)
Authors: Vethamani Malachi Edwin
Published: August 2023

None
Shivani Sivagurunathan, What Has Happened to Harry Pillai?: Two Novellas. Penang: Clarity Publishing, 2022. 267 pp. ISBN 978-967-17657-8-4
Authors: Samarawickrama Enakshi
Published: August 2023

None
Daryl Lim Wei Jie. Anything but Human. Singapore: Landmark Books, 2021. 95pp. ISBN: 978-981-18-2204-9
Authors: Foong Soon Seng
Published: August 2023

N/A
Introduction: Nationalism and Secularism in South Asian Literature
Authors: Langah Nukhbah Taj , Karmakar Goutam
Published: August 2023

Not needed
Role of SIRT1 in sepsis-induced encephalopathy: molecular targets for future therapies
Authors: Shehata Alaa , Anter Aliaa , Ahmed Al-Shaimaa
Published: August 2023

Sepsis is a life-threatening organ dysfunction that results from
dysregulated host response to infection. Multiple organ system
dysfunction syndromes are prevalent among septic patients and are
essential hallmarks of sepsis diagnosis. These syndromes involve failure
of the pulmonary, hepatic, circulatory, renal, gastrointestinal and
central nervous systems. Neurological dysfunction is part of this
syndrome and has gained research attention recently [1]. Sepsis
induces neuroinflammation, BBB disruption, cerebral hypoxia, neuronal
mitochondrial dysfunction and cell death causing sepsis-associated
encephalopathy (SAE). These pathological consequences lead to short- and
long-term neurobehavioral deficits. Till now there is no specific
treatment that directly improves SAE and its associated behavioral
impairments. In this review, we discuss the underlying mechanisms of
sepsis-induced brain injury with a focus on the latest progress
regarding neuroprotective eﬀects of SIRT1 (silent mating type
information regulation-2 homologue-1). SIRT1 is an NAD+-dependent class
III protein deacetylase. It is able to modulate multiple downstream
signals (including NF-κB, HMGB, AMPK, PGC1α and FoxO) which are involved
in the development of SAE by its deacetylation activity. There are
multiple recent studies showing the neuroprotective eﬀects of SIRT1 in
neuroinﬂammation related diseases. The proposed neuroprotective action
of SIRT1 is meant to bring a promising therapeutic strategy for managing
SAE and ameliorating its related behavioural deficits.
Ultrafast and Broadband Photodetection Based on Selenized AgSbS2 Thin Films Prepared by Spray Pyrolysis Deposition and Modified by Indium Nitrate
Authors: Zhang Zhen , Cheng Jiang , Yang Xin , Bai Dongyu , Tang Hua , Chen Xihao , Meng Xiang , Chen Genglong , Wang Shenghao , Li Lu
Published: August 2023

Miargyrite silver antimony chalcogenide (AgSbS2) exhibits a promising
photoresponse to sunlight. However, the large band gap
(~1.7 eV) limits its practical application, especially
in 1300-1550 nm range require for laser communication. Although
selenization can reduce the band gap of AgSbS2 film, the effectiveness
is hindered by the compact crystal grain structure, resulting in limited
selenization only at the top surface and an insufficient selenization
rate. In this work, we prepare a gradient structure AgSbS2(Se) film
through spray pyrolysis with a post selenization. To achieve a high
selenization rate, we construct a loose AgSbS2 precursor via
innovatively adding some indium nitrate to the spray solution. By
optimizing the process, we successfully fabricated broadband
photodetectors with a response range extending beyond 1920 nm. The
fabricated photodetectors not only exhibit excellent broadband response
characteristics but also demonstrate a high bandwidth of up to 0.3 MHz
and a rapid response time of 1.12 μs. These outstanding features
indicate great potential for application in high-speed photon
computation and communication systems. This novel gradient structure
AgSbS2(Se) film opens up new possibilities for developing
high-performance broadband photodetectors essential for advancing laser
communication technology.
Cyclophosphamide pharmacogenomics and their effect on its bioactivation and pharmacokinetics
Authors: El-Serafi Ibrahim , Steele Sinclair
Published: August 2023

Cyclophosphamide (Cy) is a prodrug that is mainly bioactivated by the
cytochrome enzyme CYP2B6. Several other enzymes are also involved in its
bioactivation and affect its kinetics. Previous studies have shown the
effect of the enzymes’ genetic polymorphisms on Cy kinetics and its
clinical outcome. These results were controversial primarily because of
the involvement of several interacting enzymes in the Cy metabolic
pathway, which can be also affected by several clinical factors as well
as other drugs interactions. In this article, we present the effect of
CYP2B6 polymorphisms on Cy kinetics since it is the main bioactivating
enzyme, as well as discussing all previously reported enzymes and
clinical factors that can alter Cy efficacy. Additionally, we present
explanations for key Cy side effects due to its extrahepatic
bioactivation. Finally, we discuss the role of busulphan in conditioning
regimens in the Cy metabolic pathway as a clinical example of drug-drug
interactions involving several enzymes. By the end of this article, our
aim is to have provided a conclusive summary of Cy pharmacogenomics and
the effect of its kinetics. The use of these findings in new strategies
for Cy personalized patient dose adjustment will certainly help in
optimizing the Cy dose and in improving the clinical outcome.
STUDY ON FABRICATION AND TESTING OF FLAX FIBER REINFORCED ALUMINIUM LAMINATES FOR AUTOMOBILE APPLICATION
Authors: M Vinod , C Anil Kumar , Sollapur Shrishail , Batakurki Chetana , Avadhani S , Kumar Mukesh
Published: August 2023

Natural fiber metal Laminates (NFML) are widely being researched upon
for their mechanical properties and in the making of metal and polymer
matrix composites. The hybrid metal-natural fiber laminate composites
have largely improved mechanical properties and can withstand greater
forces without failing. In this particular study, Aluminium is the metal
chosen and Flax fiber is being used to reinforce the Aluminium. The main
issue faced during the fabrication of such a laminate is mainly ensuring
that the natural fiber has no problem bonding with the matrix component
used. The method used was to bond the flax fabric and Aluminium sheet
using Epoxy resin as an adhesive and using compression moulding over a
period of time. It was found that untreated Flax fiber reinforced
Aluminium laminate does not have proper interfacial adhesion. The next
step was to treat the Aluminium and the Flax fiber to ensure maximum
adhesion and proper bonding. The treatment was done and the mechanical
testing of untreated and treated specimen were compared.
Networks of depressive symptoms in clinical and student populations: Similarities and differences
Authors: Novovic Zdenka , Janicic Bojan , Mihic Ljiljana , Belopavlovic Radomir
Published: August 2023

Using network analysis, we compared the BDI-II symptom groupings (i.e., communities), the ability of individual symptoms to associate with the others (i.e., centrality), the global strength of these associations, and the bridge symptoms that connect the communities in a sample of 279 depression patients (Mage = 49.9, SDage = 11.2) and in a non-clinical sample of 327 students (BDI-II score less than 19, Mage = 21.05, SDage = 1.82). The network of patients showed higher density, three communities (i.e., cognitive, affective-vegetative, and anhedonia-low energy), with sadness as the central and the strongest bridge symptom. The network of students was less consolidated, had unstable, and uninterpretable communities, with worthlessness as the central symptom, which was the strongest bridge among the communities. This study suggests some qualitative differences between depression symptoms in clinical and non-clinical populations, which manifest in their different places in networks.
Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma
Authors: Pavlovic Milorad , Ristic Tatjana , Markovic Dusanka , Ignjatovic Aleksandra , Karanikolic Aleksandar , Djordjevic Miodrag , Radic Milica , Dinic Ljubimir , Laketic Darko
Published: August 2023

Introduction/Objective. Rib fractures are common in blunt chest trauma (BCT), and when they are associated with pleural complications (PC) ? pneumothorax, hemothorax and hemopneumothorax ? the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractures in BCT, most doctors are forced to initially treat these patients through observation and conservative treatment. The goal of this research is to determine which of the investigated biomarkers of inflammation ? fibrinogen, interleukin-6 (IL-6), and C-reactive protein (CRP) ? are significantly associated with the occurrence of PC after rib fracture in BCT, and whether they can be used in stratifying patients for hospitalization and further treatment. Methods. The prospective study included 90 patients with rib fractures caused by BCT. The test group comprised 45 patients with rib fractures and the presence of PC, and the control group consisted of 45 patients with rib fractures without PC. Blood sampling was performed on admission, on the second, third, and fifth day after the injury, and PC were monitored until the seventh day after the injury. Results. Serum values of IL-6 on the second day and fibrinogen and CRP on the second and third day after injury were statistically significantly higher in patients with PC, and IL-6 showed a good discriminative ability in assessing the occurrence of PC on the second day after a rib fracture in BCT. Conclusion. The investigated biomarkers of inflammation ? fibrinogen, IL-6, and CRP ? can be used as predictors of PC after rib fracture in BCT, and their application can significantly replace clinical observation.
An integrated map of cell type-specific gene expression in pancreatic islets
Authors: M Elgamal Ruth , Kudtarkar Parul , L Melton Rebecca , M Mummey Hannah , Benaglio Paola , Okino Mei-Lin , J Gaulton Kyle
Published: August 2023

Abstract

Pancreatic islets are comprised of multiple cell types that produce hormones required for glucose homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous studies have assessed transcription across individual cell types using single cell assays; however, there is no canonical reference of gene expression in islet cell types that is also easily accessible for researchers to query and use in bioinformatics pipelines. Here we present an integrated map of islet cell type-specific gene expression from 192,203 cells from single cell RNA-sequencing of 65 non-diabetic, type 1 diabetes autoantibody positive, type 1 diabetic, and type 2 diabetic donors from the Human Pancreas Analysis Program. We identified 10 distinct cell types, annotated sub-populations of several cell types, and defined cell type-specific marker genes. We tested differential expression within each cell type across disease states, and identified 1,701 genes with significant changes in expression, with most changes observed in beta cells from donors with type 1 diabetes. To facilitate user interaction, we provide several single cell visualization and reference mapping tools, as well as open-access analytical pipelines used to create this reference. The results will serve as a valuable resource to investigators studying islet biology.
Congenital Oblique Talus Spontaneous Reduction-Case Report
Authors: Gharaibeh Ahmad
Published: August 2023

Congenital oblique talus is a very rare condition which presents as an isolated deformity or in association with neuromuscular and/or genetic disorders. Pathoanatomically the deformity shows a dislocated talonavicular and subtalar joint. The ethiology and pathogenesis are still not finally determined, although in some cases a genetic basis has been identified. The clinical picture is that of a flat longitudinal arch. Clinical diagnosis is confirmed by plain radiographic imaging of anteroposterior and lateral views. Congenital oblique talus should not be confused with other deformities of the foot, such as congenital vertical talus, which with stress view X-Ray can be reduced. The object of treatment of congenital oblique talus is to restore a normal anatomical relationship between the talus, navicular bone and calcaneus. Good early results of modified non-operative treatment using serial manipulations, physiotherapy, special shoes or cast treatment may change therapeutic concepts.
Kebutuhan Model Pembelajaran Kooperatif Menulis Akademik dengan Pendekatan Proses
Authors: Amalia Ila
Published: August 2023

Model kooperatif dalam pembelajaran menulis dengan pendekatan proses dapat digunakan sebagai strategi untuk meningkatkan kemampuan menulis mahasiswa. Penelitian ini bertujuan untuk menganalisis kebutuhan model pembelajaran kooperatif menulis akademik dengan pendekatan proses di Jurusan Tadris Bahasa Inggris. Penelitian menggunakan pendekatan kualitatif Subjek penelitian terdiri dari satu orang dosen pengampu mata kuliah Academic Writing serta dua puluh lima orang mahasiswa jurusan Tadris Bahasa Inggris (TBI). Data penelitian diperoleh melalui teknik wawancara dan penyebaran angket melaui Google Form. Data kemudian dianalisis dengan menggunakan pendekatan kualitatif dan kuantitatif. Hasil penelitian menunjukan bahwa pada saat ini belum terdapat model pembelajaran tertentu yang digunakan oleh dosen pada mata kuliah Essay Writing. Pendekatan pembelajaran menulis masih berbasis produk dan proses menulis belum sepenuhnya dilakukan oleh mahasiswa. Hasil penelitian juga menunjukan sebuah model pembelajaran menulis yang menekankan kepada aspek kerja sama dan tahapan-tahapan manulis sangat dibutuhkan dalam pembelajaran menulis akademik. Pendekatan pembelajaran menulis yang digunakan pada saat ini masih menitikberatkan kepada produk akhir, sehingga proses menulis yang sesungguhnya belum sepenuhnya dilakukan oleh mahasiswa. Penggabungan kedua aspek ke dalam sebuah model pembelajaran yang baru diyakini tidak hanya dapat meningkatkan kemampuan menulis juga keterampilan sosial mahasiswa.
Learning Loss Typology: A Proposed Framework for Categorizing Learning Loss During COVID-19 Pandemic
Authors: Pratama Putu Yoga Sathya , Nitiasih Ni Putu Kerti , Suwastini Ni Komang Arie
Published: August 2023

Learning loss has been a global issue around educational scope lately. This study aimed at proposing a framework for categorizing learning loss during the covid-19 pandemic based on article review results. A qualitative approach has been employed utilizing systematic and qualitative-critical reviews as the research design. The main subject involved 26 articles that were selected purposively. All data were analyzed interactively before the objective was set, and the results were portrayed through grounded theory by Anderson & Krathwohl's dimensions of learning. The results show that learning loss in the affective domain includes a lack of learning motivation, social interaction, self-esteem, engagement, and interest. The sources of learning loss in the affective domain are geographical factors, socio-economic factors, and the digital divide; and in the psychomotor domain are educational inequality and low competence to adapt to situations. The mitigation of learning loss in the affective domain is improving learning facilities and mental care for students in the cognitive domain is adjusting the curriculum and adapting learning methods; in the psychomotor domain is an enhancing literacy skill.
Kontribusi Kecerdasan Interpersonal, Pemenuhan Fasilitas Belajar dalam Keluarga, dan Keterampilan Sosial Terhadap Kompetensi Pengetahuan IPS Siswa
Authors: Widiartha Kadek Dwi Rahayu , Lasmawan I Wayan , Ardana I Made
Published: August 2023

Penelitian ini merupakan penelitian kuantitaif yang bertujuan untuk mengatahui (1) kontribusi kecerdasan interpersonal terhadap kompetensi pengetahuan ips; (2) kontribusi pemenuhan fasilitas belajar terhadap kompetensi pengetahuan IPS; (3) kontribusi keterampilan sosial terhadap kompetensi pengetahuan IPS; dan (4) kontribusi kecerdasan interpersonal, pemenuhan fasilitas belajar, dan keterampilan sosial terhadap kompetensi pengetahuan IPS. Penelitian ini berjenis ex post facto. Penelitian ini menggunakan 100 siswa kelas V SD sebagai sampel, yang dipilih secara acak. Instrumen yang digunakan meliputi lembar kuesioner yang datanya dianalisis secara kuantitatif dengan uji regresi linier berganda. Penelitian ini menemukan terdapat kontribusi yang signifikan pada kecerdasan interpersonal siswa terhadap kompetensi pengetahuan IPS, pemenuhan fasilitas belajar dalam keluarga terhadap kompetensi pengetahuan IPS, keterampilan sosial siswa terhadap kompetensi pengetahuan IPS, dan kecerdasan interpersonal, pemenuhan fasilitas belajar dalam keluarga, dan keterampilan sosial terhadap kompetensi pengetahuan IPS. Oleh karena itu, Dapat disimpulkan bahwa terdapat kontribusi signifikan antara kecerdasan interpersonal, pemenuhan fasilitas belajar dalam keluarga, dan keterampilan sosial terhadap kompetensi pengetahuan IPS siswa kelas V SD.
Model Pembelajaran Think Pair Share Difasilitasi Peta Konsep Meningkatkan Kemampuan Berpikir Kritis IPA Ditinjau dari Motivasi Belajar Siswa
Authors: Mudana I Ketut , Suma Ketut , Widiana I Wayan
Published: August 2023

Rendahnya hasil belajar IPA disebabkan oleh beberapa faktor, salah satunya yaitu kegiatan pembelajaran yang monoton. Penelitian ini bertujuan untuk menganalisis model pembelajaran Think Pair Share difasilitasi peta konsep terhadap peningkatan kemampuan berpikir kritis IPA ditinjau dari motivasi belajar siswa. Penelitian ini merupakan penelitian eksperimen menggunakan rancangan Pretest – posttest control group design. Jumlah populasi sebanyak 216 orang. Sampel penelitian berjumlah 96 orang yang dipilih dengan menggunakan teknik Random Sampling. Metode pengumpulan data menggunakan metode tes dan non tes. Data yang diperoleh diolah dengan menggunakan analisis varians (ANAVA) dua jalur melalui uji F dan uji Tukey. Hasil penelitian menunjukkan bahwa peningkatan kemampuan berpikir kritis IPA siswa yang mengikuti pembelajaran Think Pair Share difasilitasi peta konsep lebih tinggi. Kedua, ada pengaruh interaksi antara model pembelajaran yang digunakan dan motivasi belajar siswa terhadap peningkatan kemampuan berpikir kritis IPA. Ketiga, kelompok siswa yang memiliki motivasi belajar tinggi, peningkatan kemampuan berpikir kritis IPA siswa yang mengikuti pembelajaran dengan model pembelajaran Think Pair Share difasilitasi peta konsep lebih tinggi. Keempat, kelompok siswa yang memiliki motivasi belajar rendah, peningkatan kemampuan berpikir kritis IPA siswa yang mengikuti pembelajaran dengan model pembelajaran Think Pair Share difasilitasi peta konsep lebih rendah dibandingkan kemampuan berpikir kritis dengan model konvensional.
Development of a variance model for the prediction of water absorption and thickness swelling for an experimental design pvc reinforced composite pipes
Authors: Orhorhoro Ejiroghene Kelly , Tamuno Rogers Ibunemisam , Chukwuedo Azuka Joses
Published: August 2023

Water absorption is a significant constraint encountered when NFs reinforce polymer matrices. It is the primary cause of the breakdown of the fibre-matrix interface, resulting in swelling of the fibres, loss in the efficiency of load transfer between the matrix and the fibres, and ultimately a reduction in the strength and stiffness of the composites. This study investigated the development of a variance model for predicting water absorption and thickness swelling for an experimental design of Polyvinyl chloride (PVC) reinforced composite pipes. The quadratic model was used to model the influence of the process factors (independent variables) on the responses (i.e., water absorption and thickness swelling). Statistical analysis of the experimental data was carried out by fitting the chosen quadratic model to the data to estimate the unknown model parameters. The results revealed that the model was characterised by a high R2 value, indicating a perfect fit between the experimental observations and model predictions. The value of the variation coefficient was 3.320, which means the high precision and reliability of the model. The results of water absorption tests as a function of independent process factors showed that increasing the level of PVC in the composite material resulted in a decrease in the water absorption capacity of the material. This is desirable since an excellent composite pipe material should resist moisture intrusion.
Lake and Stream Buffer Zone Widths' Effects on Nutrient Export to Lake Rawapening, Central Java, Indonesia: A Simple Simulation Study
Authors: Nada F. Maftukhakh Hilmya , Nugroho Nunung Puji , Sofwa Nurzawani Binti Md
Published: August 2023

Lake ecosystems in Indonesia face serious environmental problems. One of those problems is eutrophication caused by excessive plant nutrients, particularly nitrogen (N) and phosphorus (P). Water quality degradation and biodiversity loss are the effects of eutrophication. The government of Indonesia (GoI) has issued a regulation on determining lake and stream buffer zones, but it has not been fully implemented in the field. Additionally, the data related to the effects of each buffer zone width is not available. This study aims to begin to fill this gap. It simulates the effect of lake and stream buffer zone widths on nutrient export to Rawapening Lake. The Nutrient Retention sub-model, which is part of InVEST (Integrated Valuation of Environmental Services and Tradeoffs) software, has been used for this research to analyse information from several data sources, including a Digital Elevation Model (DEM) and measurements of soil depth, annual rainfall, land cover/use, watershed/sub-watershed boundaries, and biophysical conditions. Several studies of eutrophication in Rawapening Lake have measured the magnitude of eutrophication but have not discussed the effects of buffer zone widths. Therefore, this study accommodates the updated data on how much effect of buffer zone widths on the reduction of nutrient export. Five scenarios of buffer zone width are considered:  30 m., 90 m., and 150 m, where the lake buffer zone widths and the stream buffer zone width are 30 m. The results indicated that the maximum nutrient export reduction of lake buffer zones was only 2.63% (for N) and 3.56% (for P). On the other hand, the 30 m stream buffer zone width reduced the nutrient export to Rawapening Lake by up to 43.05% for N and by 44.90% for P. A 30 m combined lake and stream buffer zone width slightly increases the nutrient export reduction effectiveness, i.e., 0.41% and 0.56% for N and P, respectively.
REMOTE TECHNICAL VISITS: A POSSIBLE APPROACH TO THE ENVIRONMENTAL TOPIC IN TEACHING UNITS
Authors: Santos de Souza Luana , Ferraz de toledo Renata , Piedro Pavão da Silva Leonardo , Amaral da Costa Julião Beatriz , Reolon de Oliveira Isabela , Mendonça Bernardo Isabella , Chiarella Pereira Grazielle
Published: August 2023

The COVID-19 pandemic and the distancing measures required adaptations in the entire teaching structure. In this context, the objective of this article is to report remote visits carried out for students attending High School courses integrated to the Technical and Higher Education levels about environmental topics. The visits to five companies/organizations took place by means of a project prepared by undergraduate students attending the FMU Environmental and Sanitary Engineering course, aiming to provide them with a virtual presentation of their processes in the environmental area. The participants in the visits were 231 students from High School courses integrated to the Technical level from two public schools and 152 attending courses integrated to Higher Education at a private institution. Thus, in a dynamic way, it was possible to show socio environmental activities developed by the companies/organizations, regarding different theoretical-practical aspects inherent to sustainability, such as waste management, ecological sanitation, vegetable gardens in small spaces, aquaponics systems and the importance of stingless bees, among others. It is considered that the Remote Visits Project is within a scenario marked by the expansion of educational procedures, enriching both the academic experiences of the students directly involved in the Project and those of the other students participating in the visits, due to the reflections and learning processes provided by the immersion in applied sustainability models, thus promoting interdisciplinary knowledge, sensitization and diverse information pertinent to the environmental issues addressed in the visits.