bluuebunny/crossref_metadata_2025 huggingface dataset:
Bound chiral magnonic polariton states for ideal microwave isolation
Authors: Han Youcai , Meng Changhao , Pan Hong , Qian Jie , Rao Zejin , Zhu Liping , Gui Yongsheng , Hu Can-Ming , An Zhenghua
Published: July 2023

Bound states in the continuum (BICs) present a unique solution for eliminating radiation loss. So far, most reported BICs are observed in transmission spectra, with only a few exceptions being in reflection spectra. The correlation between reflection BICs (r-BICs) and transmission BICs (t-BICs) remains unclear. Here, we report the presence of both r-BICs and t-BICs in a three-mode cavity magnonics. We develop a generalized framework of non-Hermitian scattering Hamiltonians to explain the observed bidirectional r-BICs and unidirectional t-BICs. In addition, we find the emergence of an ideal isolation point in the complex frequency plane, where the isolation direction can be switched by fine frequency detuning, thanks to chiral symmetry protection. Our results demonstrate the potential of cavity magnonics and also extend the conventional BICs theory through the application of a more generalized effective Hamiltonians theory. This work offers an alternative idea for designing functional devices in general wave optics.
Spatially offset optical coherence tomography: Leveraging multiple scattering for high-contrast imaging at depth in turbid media
Authors: Untracht Gavrielle R. , Chen Mingzhou , Wijesinghe Philip , Mas Josep , Yura Harold T. , Marti Dominik , Andersen Peter E. , Dholakia Kishan
Published: July 2023

The penetration depth of optical coherence tomography (OCT) reaches well beyond conventional microscopy; however, signal reduction with depth leads to rapid degradation of the signal below the noise level. The pursuit of imaging at depth has been largely approached by extinguishing multiple scattering. However, in OCT, multiple scattering substantially contributes to image formation at depth. Here, we investigate the role of multiple scattering in OCT image contrast and postulate that, in OCT, multiple scattering can enhance image contrast at depth. We introduce an original geometry that completely decouples the incident and collection fields by introducing a spatial offset between them, leading to preferential collection of multiply scattered light. A wave optics–based theoretical framework supports our experimentally demonstrated improvement in contrast. The effective signal attenuation can be reduced by more than 24 decibels. Notably, a ninefold enhancement in image contrast at depth is observed in scattering biological samples. This geometry enables a powerful capacity to dynamically tune for contrast at depth.
TCRward personalized transplant therapies
Authors: Chadha Ashima , Maltzman Jonathan S.
Published: July 2023

scRNA/TCRseq of kidney biopsies from acute cellular rejection reveals limited clonality and diverse T cell phenotypes.
ARMC5-negative primary bilateral macronodular adrenal hyperplasia
Authors: Sol Bastiaan , Carprieaux Marilyn , De Leu Nico
Published: July 2023

A woman in her 60s with chronic fatigue, depressed mood and proximal muscle weakness was referred to our endocrinology department. Physical examination revealed facial plethora, atrophic skin and ankle oedema. Adjuvant blood and urine analyses indicated endogenous ACTH-independent Cushing syndrome. Abdominal imaging showed bilateral macronodular adrenals, measuring 58.9 × 29.7 mm on the right and 55.6 × 42.6 mm on the left. Primary bilateral macronodular adrenal hyperplasia was confirmed by pathology after bilateral adrenalectomy. Gradual mental and physical recovery was observed in the months following surgery. Genetic sequencing failed to reveal mutations in the ARMC5 gene.

Cushing syndrome is a rare entity that should be suspected when typical clinical signs, including skin atrophy with ecchymosis, muscle weakness or coloured stretch marks, are present. Primary bilateral macronodular adrenal hyperplasia is an uncommon cause of endogenous Cushing syndrome. It is a benign condition characterised by adrenal macronodules exceeding 1 cm and hypercorticism.
Clinical presentation of idiopathic CD4 lymphocytopenia
Authors: Tadjali Armand , Pan Sharon , Perli Elias , Keaton Toni
Published: July 2023

An otherwise healthy man (60s) presented to our emergency department 5 years ago with stroke-like symptoms. Underlying cryptococcal meningitis infection was ultimately discovered leading to extensive workup to rule out underlying malignancy and HIV infection. Results returned negative with the exception of a CD4 count less than 25 /mm3. Several years later, he again presented to the emergency department with fatigue. He was then found to have severe anaemia with underlyingMycobacterium aviumcomplex (MAC) infection involving the bone marrow and a left psoas abscess. After multiple courses of antibiotic therapy targeted towards MAC, the infection persisted due to bone marrow involvement. By diagnosis of exclusion, he was eventually found to have idiopathic CD4 lymphocytopenia. Here we describe this condition, which has the potential to cause significant morbidity, and obligates the need for high clinical suspicion for timely diagnosis to enhance life quality and outcomes for patients.
Progressive multifocal leukoencephalopathy associated with carbamazepine-induced immune dysfunction and recovery after carbamazepine cessation
Authors: Perrott Sarah , Khan Qaisar Imran , Counsell Carl E , Macleod Angus D
Published: July 2023

A patient with epilepsy on carbamazepine developed a rapidly progressive cerebellar syndrome. Serial MRI showed progressive posterior fossa T2/fluid attenuated inversion recovery hyperintensity with gadolinium enhancement. Standard cerebrospinal fluid (CSF) analysis was normal. Detection of John Cunningham virus DNA in the CSF confirmed progressive multifocal leukoencephalopathy (PML). The only evidence of immune disfunction was hypogammaglobulinaemia and longstanding lymphopenia. After cessation of carbamazepine, the lymphocyte count and immunoglobulin levels returned to normal and the PML resolved, with good clinical recovery. No specific treatments for PML were given. We hypothesise that PML in this case was due to carbamazepine-induced prolonged mild immunosuppression with reconstitution of the immune system after carbamazepine cessation, resulting in recovery from PML. Effects of anticonvulsants on immune function and infection risk may contribute to epilepsy-related morbidity and mortality. Further investigation is needed to determine the frequency of immune dysfunction and infections in patients treated with anticonvulsants such as carbamazepine and whether interventions could reduce infection risk.
Severity and outcomes of Omicron variant of SARS-CoV-2 compared to Delta variant and severity of Omicron sublineages: a systematic review and metanalysis
Authors: Relan Pryanka , Motaze Nkengafac Villyen , Kothari Kavita , Askie Lisa , Le Polain de Waroux Olivier , Van Kerkhove Maria D , Diaz Janet , Tirupakuzhi Vijayaraghavan Bharath Kumar
Published: July 2023

Objectives

To compare severity and clinical outcomes from Omicron as compared with the Delta variant and to compare outcomes between Omicron sublineages.

Methods

We searched the WHO COVID-19 Research database for studies that compared clinical outcomes for patients with Omicron variant and the Delta variant, and separately Omicron sublineages BA.1 and BA.2. A random-effects meta-analysis was used to pool estimates of relative risk (RR) between variants and sublineages. Heterogeneity between studies was assessed using the I2index. Risk of bias was assessed using the tool developed by the Clinical Advances through Research and Information Translation team.

Results

Our search identified 1494 studies and 42 met the inclusion criteria. Eleven studies were published as preprints. Of the 42 studies, 29 adjusted for vaccination status; 12 had no adjustment; and for 1, the adjustment was unclear. Three of the included studies compared the sublineages of Omicron BA.1 versus BA.2. As compared with Delta, individuals infected with Omicron had 61% lower risk of death (RR 0.39, 95% CI 0.33 to 0.46) and 56% lower risk of hospitalisation (RR 0.44, 95% CI 0.34 to 0.56). Omicron was similarly associated with lower risk of intensive care unit (ICU) admission, oxygen therapy, and non-invasive and invasive ventilation. The pooled risk ratio for the outcome of hospitalisation when comparing sublineages BA.1 versus BA.2 was 0.55 (95% 0.23 to 1.30).

Discussion

Omicron variant was associated with lower risk of hospitalisation, ICU admission, oxygen therapy, ventilation and death as compared with Delta. There was no difference in the risk of hospitalisation between Omicron sublineages BA.1 and BA.2.

PROSPERO registration number

CRD42022310880.
Evaluation of the safety and tolerability of exogenous ketosis induced by orally administered free beta-hydroxybutyrate in healthy adult subjects
Authors: Pimentel-Suarez Lisa Isabel , Soto-Mota Adrian
Published: July 2023

Beta-hydroxybutyrate (D-BHB) is a metabolite with intrinsic signalling activity that has gained attention as a potentially clinically useful supplement. There are available supplements for inducing ketosis: ketone salts, ketone esters and medium-chain triglycerides. Even when all of them raise D-BHB in the blood and all are safe and well tolerated, they significantly differ in their safety profile, their palatability and their price. A fourth and potentially interesting option is to use biologically identical D-BHB, which it is already commercially available in the USA (American Ketone) and Greater China (MedPHA). However, its safety and tolerability had not yet been documented in the scientific literature. We evaluated the safety and tolerability of orally administered free D-BHB in a gender and age-balanced sample of 24 asymptomatic and overtly healthy adults. No participant showed acid-base abnormalities or electrolyte abnormalities. Secondary symptoms were reported after only 6.2% of all drink takes and none of the reports described the symptom as ‘severe’. The most frequently reported secondary effects (19/720 or 2.6%) were gastrointestinal discomfort, headache (7/720 or 1%) and loss of appetite (7/720 or 1%). No correlation between weight-adjusted dose and frequency of secondary symptoms was observed. Free D-BHB was a safe and well-tolerated intervention for inducing sustained exogenous ketosis. Being bioidentical, salt-free and lacking intermediate metabolites, this form of supplementation could have a larger safety spectrum than salt or alcohol-based exogenous ketones. More research is warranted to assess its clinical efficacy in those clinical scenarios in which achieving ketosis rapidly could be beneficial.
Programme and policy perspectives towards a tobacco-free generation in India: findings from a qualitative study
Authors: Bassi Shalini , Arora Monika , Thapliyal Nishibha , Kulkarni Muralidhar M , Bhagawath Rohith , Bogdanovica Ilze , Kamath Veena G , Britton John , Bains Manpreet
Published: July 2023

Objective

This study explored multistakeholder perspectives on existing adolescent-specific tobacco control policies and programmes, to advance India’s transition towards a tobacco-free generation.

Design

Qualitative semi-structured interviews.

Setting

Interviews were conducted with officials involved in tobacco control at the national (India), state (Karnataka), district (Udupi) and village level. Interviews were audio recorded, transcribed verbatim and analysed thematically.

Participants

Thirty-eight individuals representing national (n=9), state (n=9), district (n=14) and village (n=6) levels, participated.

Results

The study findings highlighted the need to strengthen and amend the existing Tobacco Control Law (2003) provisions, particularly in the vicinity of schools (Sections 6a and 6b). Increasing the minimum legal age to buy tobacco from 18 to 21 years, developing an ‘application’ for ‘compliance and monitoring indicators’ in Tobacco-Free Educational Institution guidelines were proposed. Policies to address smokeless tobacco use, stricter enforcement including regular monitoring of existing programmes, and robust evaluation of policies was underscored. Engaging adolescents to co-create interventions was advocated, along with integrating national tobacco control programmes into existing school and adolescent health programmes, using both an intersectoral and whole-societal approach to prevent tobacco use, were recommended. Finally, stakeholders mentioned that when drafting and implementing a comprehensive national tobacco control policy, there is a need to adopt a vision striving toward a tobacco-free generation.

Conclusion

Strengthening and developing tobacco control programmes and policies are warranted which are monitored and evaluated rigorously, and where adolescents should be involved, accordingly.
Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map
Authors: Ocan Moses , Loyce Nakalembe , Ojiambo Kevin Ouma , Kinengyere Alison Annet , Apunyo Robert , Obuku Ekwaro A
Published: July 2023

Introduction

With the rising resistance to artemisinin-based combination treatments, there is a need to hasten the discovery and development of newer antimalarial agents. Herbal medicines are key for the development of novel drugs. Currently, herbal medicine usage in communities for treatment of malaria symptoms is common as an alternative to conventional (modern) antimalarial agents. However, the efficacy and safety of most of the herbal medicines has not yet been established. Therefore, this systematic review and evidence gap map (EGM) is intended to collate and map the available evidence, identify the gaps and synthesise the efficacy of herbal antimalarial medicines used in malaria affected regions globally.

Methods and analysis

The systematic review and EGM will be done following PRISMA and Campbell Collaboration guidelines respectively. This protocol has been registered in PROSPERO. Data sources will include PubMed, MEDLINE Ovid, EMBASE, Web of Science, Google Scholar and grey literature search. Data extraction will be done in duplicate using a data extraction tool tailored in Microsoft Office excel for herbal antimalarials discovery research questions following the PICOST framework. The Risk of Bias and overall quality of evidence will be assessed using Cochrane risk of bias tool (clinical trials), QUIN tool (in vitro studies), Newcastle-Ottawa tool (observational studies) and SYRCLE’s risk of bias tool for animal studies (in vivo studies). Data analysis will be done using both structured narrative and quantitative synthesis. The primary review outcomes will be clinically important efficacy and adverse drug reactions. Laboratory parameters will include Inhibitory Concentration killing 50% of parasites, IC50;Ring Stage Assay, RSA0–3 hou;Trophozoite Survival Assay, TSA50.

Ethics and dissemination

The review protocol was approved by the School of Biomedical Science Research Ethics Committee, Makerere University College of Health Sciences (SBS-2022-213).

PROSPERO registration number

CRD42022367073.
Efficacy of botulinum toxin A injection in pelvic floor muscles in chronic pelvic pain patients: a study protocol for a multicentre randomised controlled trial
Authors: Spruijt Melle , Kerkhof Manon , Rombouts Marian , Brohet Richard , Klerkx Wenche
Published: July 2023

Introduction

Chronic pelvic pain (CPP) is a common multifactorial condition affecting 6%–27% of women aged 18–50 years worldwide. The aim of this randomised controlled trial (RCT) is to investigate the efficacy and safety of botulinum toxin A (BTA) injection compared with placebo injections in the pelvic floor muscles in women with CPP to improve pain, function and quality of life.

Methods and analysis

This is a study protocol for a multicentre, double-blinded placebo controlled RCT conducted in five gynaecology departments across the Netherlands. A total of 94 women over 16 years, with at least 6 months of CPP without anatomical cause and pelvic floor hypertonicity refractory to first-line pelvic floor physical therapy will be included. Participants will be randomised equally to BTA or placebo, both following physical therapy and (re-)education on the pelvic floor at 4, 8, 12 and 26 weeks after intervention. Multiple validated questionnaires focusing on pain, quality of life and sexual function will be collected at baseline and during all follow-up visits. Statistical analysis includes mixed models for repeated measurements.

Ethics and dissemination

Ethical approval (NL61409.091.17) was obtained from Radboud University Medical Research Ethics Committee (MREC) and Central Committee on Research involving human Subjects (CCMO). The findings will be presented through international conferences and peer-reviewed scientific journals.

Trial registration number

EudraCT number (2017-001296-23), CCMO/METC number: NL61409.091.17.
Application of high-flow nasal cannula in fibreoptic bronchoscopy after congenital heart surgery: a retrospective cohort study
Authors: Zheng Yi-Rong , Chen Xiu-Hua , Zhou Si-Jia
Published: July 2023

Background

The purpose of this study was to compare the effectiveness and safety of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in fibreoptic bronchoscopy (FB) after congenital heart surgery (CHS) in children.

Methods

We did a retrospective cohort study using patients from the electronic medical record system of Fujian Children’s Hospital in China. The study population was children who underwent FB in the cardiac intensive care unit after CHS for 1 year (May 2021–May 2022). Children were classified into HFNC and COT groups according to their oxygen therapy during FB. The primary outcome was oxygenation indices during FB, including pulse oximeter oxygen saturation (SpO2) and transcutaneous oxygen tension (TcPO2) during FB. Secondary outcomes were the number of interruptions during FB and their causes, and complications after FB.

Results

We identified 107 children from the electronic medical record system, and 102 children after CHS were finally included in the study (53 in the HFNC group and 49 in the COT group). During the FB examination, TcPO2and SpO2were significantly higher in the HFNC group than in the COT group (TcPO2: 90.3±9.3 vs 80.6±11.1 mm Hg; SpO2: 95.6±2.5 vs 92.1%±2.0%, p<0.001) and the transcutaneous carbon dioxide tension was significantly lower than in the COT group (39.6±3.0 vs 43.5±3.9 mm Hg, p<0.001). During the FB, a total of 20 children in the COT group had 24 interruptions, and 8 children in the HFNC group had 9 interruptions (p=0.001). In terms of postoperative complications, eight cases had complications in the COT group and four complications in the HFNC group (p=0.223).

Conclusions

Among children undergoing FB after CHS, the application of HFNC was associated with better oxygenation and fewer procedural interruptions compared with COT, without an increased risk of postoperative complications.
Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses
Authors: Zhang Shuai , Zhao Liwei , Guo Mengfei , Liu Peng , Li Sijing , Xie Wei , Tian Ai-Ling , Pol Jonathan G , Chen Hui , Pan Hui , Mao Misha , Li Yumei , Zitvogel Laurence , Jin Yang , Kepp Oliver , Kroemer Guido
Published: July 2023

Background

Most immunotherapies approved for clinical use rely on the use of recombinant proteins and cell-based approaches, rendering their manufacturing expensive and logistics onerous. The identification of novel small molecule immunotherapeutic agents might overcome such limitations.

Method

For immunopharmacological screening campaigns, we built an artificial miniature immune system in which dendritic cells (DCs) derived from immature precursors present MHC (major histocompatibility complex) class I-restricted antigen to a T-cell hybridoma that then secretes interleukin-2 (IL-2).

Results

The screening of three drug libraries relevant to known signaling pathways, FDA (Food and Drug Administration)-approved drugs and neuroendocrine factors yielded two major hits, astemizole and ikarugamycin. Mechanistically, ikarugamycin turned out to act on DCs to inhibit hexokinase 2, hence stimulating their antigen presenting potential. In contrast, astemizole acts as a histamine H1 receptor (H1R1) antagonist to activate T cells in a non-specific, DC-independent fashion. Astemizole induced the production of IL-2 and interferon-γ (IFN-γ) by CD4+and CD8+T cells both in vitro and in vivo. Both ikarugamycin and astemizole improved the anticancer activity of the immunogenic chemotherapeutic agent oxaliplatin in a T cell-dependent fashion. Of note, astemizole enhanced the CD8+/Foxp3+ratio in the tumor immune infiltrate as well as IFN-γ production by local CD8+T lymphocytes. In patients with cancer, high H1R1 expression correlated with low infiltration by TH1 cells, as well as with signs of T-cell exhaustion. The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), then inducing a state of protective long-term immune memory. The NSCLC-eradicating effect of astemizole plus oxaliplatin was lost on depletion of either CD4+or CD8+T cells, as well as on neutralization of IFN-γ.

Conclusions

These findings underscore the potential utility of this screening system for the identification of immunostimulatory drugs with anticancer effects.
Self-evidence-based digital care programme improves health-related quality of life in adults with a variety of autoimmune diseases and long COVID: a retrospective study
Authors: Bundy Nicole , De Jesus Mackenzie , Lytle Millennia , Calabrese Leonard , Gobin Christina , Dyhrberg Mette
Published: July 2023

Objective

To retrospectively investigate the feasibility and impact on health-related quality of life (HRQoL) of a digital care programme (DCP) designed to guide personalised diet and integrative interventions in a variety of autoimmune diseases and long COVID.

Methods

Adults who participated in the DCP between April 2020 and June 2022, and for whom baseline (BL) and end-of-programme (EOP) Patient-Reported Outcomes Measurement Information System (PROMIS) scores were available, were included in this retrospective study. Changes from BL to EOP were calculated using standardised T-scores.

Results

Two hundred two adults between 17 and 82 years old were included. Diagnoses included: rheumatoid arthritis (20.1%); long COVID (14.9%); psoriatic arthritis (10.9%); psoriasis (8.9%); systemic lupus erythematosus (6.4%); inflammatory bowel disease (5.9%); multiple sclerosis (5.9%); ankylosing spondylitis (5.4%) and other (23.3%). On average, individuals entered observations 7.6 times/day on 86% of programme days, attended 14 coach sessions and completed the programme in an average of 17.2 weeks. Statistically significant improvements were seen in all 10 PROMIS domains analysed. Individuals with higher severity of compromise at BL experienced greater average improvements than all-comers in all 10 PROMIS domains included.

Conclusion

An evidence-based DCP that uses patient data to help identify hidden symptom triggers and guide personalised dietary and other non-pharmacological interventions was associated with a high level of engagement and adherence and statistically significant, clinically meaningful improvements in HRQoL. Those with the least favourable PROMIS scores at BL experienced the greatest improvements.
Advances in the Application of Traditional Chinese Medicine Using Artificial Intelligence: A Review
Authors: Zhang Sheng , Wang Wei , Pi Xitian , He Zichun , Liu Hongying
Published: July 2023

Traditional Chinese medicine (TCM), as one of the crystallizations of Chinese wisdom, emphasizes the balance of Yin and Yang to keep the body healthy. Under the theoretical guidance of a holistic view, the diagnostic process in TCM has characteristics of subjectivity, fuzziness, and complexity. Therefore, realizing standardization and achieving objective quantitative analysis are the bottlenecks of the development of TCM. The emergence of artificial intelligence (AI) technology has brought unprecedented challenges and opportunities to traditional medicine, which is expected to provide objective measurements and improve the clinical efficacy. However, the combination of TCM and AI is still in its infancy and currently faces many challenges. Therefore, this review provides a comprehensive discussion of the existing advances, problems, and prospects of the applications of AI technologies in TCM with the hope of promoting a better understanding of the TCM modernization and intellectualization.
Comment on “Noether symmetry analysis in Chameleon field cosmology”
Authors: Paliathanasis Andronikos
Published: July 2023

We review the Noether symmetry analysis for the Chameleon cosmology presented in R. Bhaumik, S. Dutta and S. Chakraborty, Int. J. Mod. Phys. A 37, 2250018 (2022). We show that the classification problem for the field equations in Chameleon cosmology is still open.
Dynamics of non-Newtonian synovial fluid through permeable membrane with periodic filtration
Authors: Maqbool K. , Siddiqui A. M. , Mehboob H. , Tahir A.
Published: July 2023

This research measures the flow of synovial fluid through permeable membrane. It is assumed in this study that the ultrafiltration of blood plasma is a continuous function and repeatedly forms the action to keep synovial fluid normal in the joints. The novelty of this research is to analyze the rheology of synovial fluid under the periodic filtration rate within the membrane. To estimate the pressure and shear stress which are essential for the flow of synovial fluid between the synovial joints, mathematical modeling has been made for the synovial fluid flow through permeable membrane by the laws of mass and momentum and viscoelastic LPTT fluid model. The LPTT fluid has the viscoelastic effects in the presence of relaxation time, therefore for synovial fluid the present fluid model represents the best rheological properties. To find the analytical results for the rheology of the synovial fluid, a method proposed by Langlois is used. This research concludes that the pressure difference and transverse velocity are high when the periodic filtration is cosine type whereas the shear stress on the wall is high for sine type of filtration.
Computational predictions of CeO2 using HSE03: An ab initio investigation
Authors: Tse Geoffrey
Published: July 2023

In this paper, the structural, electronic, optical, and mechanical properties of the hexagonal Ceria CeO2 have been studied with hybrid functionals. The rare-earth oxide compound exhibits a [Formula: see text] indirect bandgap, with a bandgap energy of 2.706 eV. The electronic bandstructure has been described in detail in terms of orbital states. The rare-earth Ce f orbital contributes to the conduction band and transitional Ce d, O s electron orbitals to the valence bands. Our optical spectra also fully explain the structural and electronic properties of the material. (i.e. atomic-bonding, density or capacity inside Cerium oxide system, and the excitation of electrons to transfer from valence O 2p to conduction Ce f orbitals, leading to orbital hybridizations, etc.). Finally, our elastic coefficients verify the mechanical stability of our Ceria system. Our bandgap energy found is in excellent agreement with the experimental data. A high optical absorption coefficient of up to [Formula: see text] cm[Formula: see text] is found, indicating a good material absorption within the ultraviolet C (UVC) range. The findings of this work would be beneficial to both theoretical and experimental research works to explore the potential applications of CeO2 in optoelectronics devices.
Artistic Image Style Transfer Based on CycleGAN Network Model
Authors: Wei Yanxi
Published: July 2023

With the development of computer technology, image stylization has become one of the hottest technologies in image processing. To optimize the effect of artistic image style conversion, a method of artistic image style conversion optimized by attention mechanism is proposed. The CycleGAN network model is introduced, and then the generator is optimized by the attention mechanism. Finally, the application effect of the improved model is tested and analyzed. The results show that the improved model tends to be stable after 40 iterations, the loss value remains at 0.3, and the PSNR value can reach up to 15. From the perspective of the generated image effect, the model has a better visual effect than the CycleGAN model. In the subjective evaluation, 63 people expressed satisfaction with the converted artistic image. As a result, the cyclic generative adversarial network model optimized by the attention mechanism improves the clarity of the generated image, enhances the effect of blurring the target boundary contour, retains the detailed information of the image, optimizes the image stylization effect, and improves the image quality of the method and application value of the processing field.
Modeling the Vertical Flux of Organic Carbon in the Global Ocean
Authors: Burd Adrian B.
Published: July 2023

The oceans play a fundamental role in the global carbon cycle, providing a sink for atmospheric carbon. Key to this role is the vertical transport of organic carbon from the surface to the deep ocean. This transport is a product of a diverse range of physical and biogeochemical processes that determine the formation and fate of this material, and in particular how much carbon is sequestered in the deep ocean. Models can be used to both diagnose biogeochemical processes and predict how the various processes will change in the future. Global biogeochemical models use simplified representations of food webs and processes but are converging on values for the export of organic carbon from the surface ocean. Other models concentrate on understanding specific processes and can be used to develop parameterizations for global models. Model development is continuing by adding representations and parameterizations of higher trophic levels and mesopelagic processes, and these are expected to improve model performance.
Behavioral Economics and Neuroeconomics of Environmental Values
Authors: Koundouri Phoebe , Hammer Barbara , Kuhl Ulrike , Velias Alina
Published: July 2023

Identifying mechanisms of real-life human decision-making is central to inform effective, human-centric public policy. Here, we report larger trends and synthesize preliminary lessons from behavioral economic and neuro-economic investigations focusing on environmental values. We review the currently available evidence at different levels of granularity, from insights into how individuals value natural resources (individual level), evidence from work on group externalities, common pool resources, and social norms (social group level) to the study of incentives, policies, and their impact (institutional level). At each level, we identify viable directions for future scientific research and actionable items for policy-makers. Coupled with new technological and methodological advances, we suggest that behavioral economic and neuroeconomic insights may inform an effective strategy to optimize environmental resources. We conclude that the time is ripe for action to enrich policies with scientifically grounded insights, making an impact in the interest of current and future generations.
Color Tuning and Optical Temperature Sensing Properties of Upconversion Emission in Yb3+/Er3+/Tm3+Doped Boro-Zinctellurite Glasses
Authors: Eryurek Gonul , Tabanli Sevcan , Buhari Thami , Erdem Murat
Published: July 2023

Zinc borotellurite (B2O3/BaO/ZnO/TeO2) glasses co-doped with Tm3+/Yb3+, Er3+/Yb3+ and tri-doped Tm3+/Er3+/Yb3+ were prepared using the traditional melt quenching method. Optical absorption spectra were measured in the wavelength range of 350 nm-1100 nm at room temperature. The optical bandgap (Eg) and Urbach energy were calculated from Tauc’s plot. Blue and green emissions that can be seen by the naked eye were generated under 975 nm laser light excitation in doped Tm3+/Yb3+ and Er3+/Yb3+ doped glasses. Shifts in both blue and green color coordinates were seen as the excitation power density increased from 0.5 to 15.1 W cm−2. A white light generation was generated in glass doped with Tm3+/Er3+/Yb3+ ions, although a noticeable shift was not observed in both blue and green color coordinates for the same excitation power density range. Temperature sensing properties were investigated using the fluorescence intensity ratio of upconversion green emissions from the two thermally coupled 2H11/2 and 4S3/2 levels of Er3+ ions between 304 K and 443 K. The maximum sensitivity of the glasses doped with Er3+ and Er3+/Yb3+ were found to be 7.2 × 10−3 K−1 and 1.2 × 10−2 K−1 at 429 K, respectively.
Seasonal Migration Zone of Skipjack Tuna (Katsuwonus pelamis) in the South Java Sea Using Multisensor Satellite Remote Sensing
Authors: Semedi Bambang , Hardoko Hardoko , Dewi Citra Satrya Utama , Syam’s Nova Dewi Safitri , Diza Novia Fara , Bayuaji Gerardus David Ady Purnama
Published: July 2023

Skipjack tuna (Katsuwonus pelamis) is the most dominating tuna species caught in the Indian Ocean. However, tuna fishermen in the Indian Ocean still face difficulties determining potential skipjack tuna fishing grounds due to limited geographic information. An attempt to improve information regarding potential skipjack tuna fishing grounds is through modeling the SST, SSC, SSH, and SSS oceanographic parameters with skipjack tuna distribution using GIS. The characteristics of the skipjack tuna habitat can be found through the generalized additive model (GAM) statistical analysis using data of skipjack tuna catch and oceanographic parameters from satellite imagery. The integrated GIS and GAM methods can improve the study of the habitat of skipjack tuna species. Therefore, this research is aimed at analyzing the condition and SST, SSC, SSH, and SSS variations in 2016-2021 in the South Java Sea; at predicting the correlation of SST, SSC, SSH, and SSS towards skipjack tuna catch in 2016-2021 in the South Java Sea using GAM; and at creating a map of skipjack tuna seasonal migration zones. The data included skipjack tuna catches, number of trips, and skipjack tuna fishing coordinates in 2016-2021 from PPS Cilacap and PPP Pondokdadap. The oceanographic parameter data in 2016-2021 was derived from Aqua MODIS level 3 (SST and SSC) and CMEMS (SSH and SSS) satellite imagery. The results showed that the average values of oceanographic parameters at skipjack tuna fishing ground coordinates in the South Java Sea (2016-2021) were SST (26.050-30.816°C), SSC (0.094-0.564 mg/m3), SSH (0.268-0.639 m), and SSS (33.075-34.514 psu). The best GAM modeling was the combination of four oceanographic parameter variables with an AIC value of 45357.92. Skipjack tuna in the South Java Sea migrates southeast during the west monsoon season to the first transitional season and tends to migrate northwest during the east monsoon season to the second transitional season.
Optimization of the Synthesis Parameters and Application of Cellulose Nanocrystals as Binders in Capacitors
Authors: Castro-Guerrero Carlos F. , González-Benítez Andrea , Rodríguez-Rodríguez Abisaí , Delgado-Arroyo Filemón , León-Silva Ulises , Morales-Cepeda Ana B. , López-González Francisco A. , Rodas-Grapain Arturo , Díaz-Guillén Mario R.
Published: July 2023

Cellulose nanocrystals (CNCs) are a very versatile material, and optimizing the reaction conditions to obtain them is vital for cost savings, purity, selectivity, or performance. In this study, the reaction conditions of the CNCs were tested, as well as their application as binders for the fabrication of electrodes of a symmetric capacitor (based on activated carbon). The resulting CNCs were physicochemically characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, atomic force microscopy, and its capacitive properties using cyclic voltammetry (CV). It was found that the best reaction conditions were at 45°C, 30 and 45 minutes, and 64 wt%. The CNCs were used as a binder, as they conferred stability to the electrodes and prevented the crumbling of the activated carbon electrodes. The CV measurements showed a capacitor behavior; CNCs can be used in energy storage applications.
A Multiphase Semistatic Training Method for Swarm Confrontation Using Multiagent Deep Reinforcement Learning
Authors: Cai He , Luo Yaoguo , Gao Huanli , Chi Jiale , Wang Shuozhe
Published: July 2023

In this paper, we propose a multiphase semistatic training method for swarm confrontation using multi‐agent deep reinforcement learning. In particular, we build a swarm confrontation game, the 3V3 tank fight, based on the Unity platform and train the agents by a MDRL algorithm called MA‐POCA, coming with the ML‐Agent toolkit. By multiphase learning, we split the traditional single training phase into multiple consecutive training phases, where the performance level of the strong team for each phase increases in an incremental way. On the other hand, by semistatic learning, the strong team in all phases will stop learning when fighting against the weak team, which reduces the possibility that the weak team keeps being defeated and learns nothing at all. Comprehensive experiments prove that, in contrast to the traditional single‐phase training method, the multiphase semistatic training method proposed in this paper can significantly increase the training efficiency, shedding lights on how the weak could learn from the strong with less time and computational cost.
The Impact of Smartphone and Social Media Use on Adolescent Sleep Quality and Mental Health during the COVID-19 Pandemic
Authors: Lee Young , Blebea Judy , Janssen Furhut , Domoff Sarah E.
Published: July 2023

Objective. Social media (SM) has gained almost ubiquitous use in society and especially among adolescents; however, there has been rising concern over its negative consequences, including the effects on child behavioral health, such as sleep and internalizing symptoms. Research elucidating the impacts of SM use on young people should be conducted to inform healthier SM usage. This study seeks to understand how SM use and use of phones around bedtime associates with worse sleep quality, depression, and anxiety among youth during the peak of the COVID-19 pandemic and social distancing. Methods. This project uses archival data collected in fall 2020 through school-based surveys to adolescents in a rural school district in Michigan. There were a total of 200 participants (91.7% response rate) of which 180 adolescents (12-15 years old, 40.0% male, 55.6% female, 3.9% nonbinary) were included in the analysis based on their SM use, the majority of whom identified as white (91.7%). Results. Linear regression analyses indicated that higher self-reported SM use was associated with poorer sleep quality and greater depression (

p
<
0.05

). Sleep quality mediated the association between SM use and depression (

p
<
0.05

). Furthermore, youth who brought their smartphones to bed with them had poorer sleep quality than those without phones (

p
<
0.05

). SM use was not associated with anxiety after controlling for age and gender. Conclusions. SM use is associated with higher rates of adolescent depression; however, sleep appears to mediate the relationship. The impacts of bringing a smartphone to bed and self-reported SM use on adolescent mental health may be better predicted via sleep disruption even during a widescale event such as COVID-19.
Supplementary Table S6 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Table S6. Clinical response annotation of the scRNAseq dataset obtained from BCCs treated with ICI.
Supplementary Table S5 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Table S5. MC1, MC2 and MC3 secretome genesets.
Supplementary Table S3 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Table S3. Cluster marker genes of the Fibroblast populations.
Supplementary Table S2 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Table S2. Spatial TME1 (STME1) and TME2 (STME2) gene signatures.
Supplementary Table S1 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Table S1. Published immunoreactive and immunosuppressive gene signatures.
Supplementary Figure S9 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S9: Immunosuppressive, Activin A-exposed macrophages are found in both human SCC and melanomas.
Supplementary Figure S6 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S6: Macrophages harbor different profiles in TME1 and TME2.
Supplementary Figure S5 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S5: TME2 is enriched in immunosuppressive macrophages, but devoid of immunoreactive CD8 T cells.
Supplementary Figure S3 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S3: Immunosuppressive TME2 are enriched in ECM-remodeling CAFs.
Supplementary Figure S10 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S10: Unsupervised clustering of secretome gene expression reflects Macrophage subpopulations.
Supplementary Figure S1 from Activin A–Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer
Authors: Pich-Bavastro Christine , Yerly Laura , Di Domizio Jeremy , Tissot-Renaud Stéphanie , Gilliet Michel , Kuonen François
Published: July 2023

Supplementary Figure S1: Patient information, quality controls and immune characterization of TME1 and TME2.
Supplemental Figure S2 from Cost-effectiveness of p16/Ki-67 Dual-Stained Cytology Reflex Following Co-testing with hrHPV Genotyping for Cervical Cancer Screening
Authors: Harper Diane M. , Anderson Rye J. , Baker Ed , Yu Tiffany M.
Published: July 2023

Supplemental Figure S2 shows the proportion of the PSA simulations that were cost-effective at varying willingness-to-pay thresholds
Supplemental Figure S1 from Cost-effectiveness of p16/Ki-67 Dual-Stained Cytology Reflex Following Co-testing with hrHPV Genotyping for Cervical Cancer Screening
Authors: Harper Diane M. , Anderson Rye J. , Baker Ed , Yu Tiffany M.
Published: July 2023

Supplemental Figure S1 shows tornado diagrams of range of results observed in the one-way sensitivity analyses
Supplementary Table S5 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: July 2023

Supplementary Table S5 lists the antibodies used for CyTOF
Supplementary Table S8 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: July 2023

Table S8: Multimodal analysis of shCEBPA versus shCTL MOLM14 cell line
Supplementary Table S3 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: July 2023

Supplementary Table S3 lists the primers used for qPCR
Supplementary Table S2 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: July 2023

Supplementary Table S2 lists the antibodies used for western blots