bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of enasidenib in the treatment of mutant IDH2 acute myeloid leukemia
Authors: Abou Dalle Iman , DiNardo Courtney D.
Published: June 2018

Recurrent mutations affecting cellular metabolism and epigenetic regulation are implicated in the pathogenesis of acute myeloid leukemia (AML). Isocitrate dehydrogenase 2 ( IDH2) gene mutations are described in 12% of patients with AML and 5% of patients with myelodysplastic syndromes. IDH2 enzyme is involved in the Krebs cycle, catalyzing α-ketoglutarate from isocitrate. Mutant IDH2 enzymes acquire a neomorphic enzymatic activity with the ability to produce 2-hydroxyglutarate from α-ketoglutarate, inhibiting multiple α-ketoglutarate-dependent dioxygenase reactions; leading to aberrant DNA hypermethylation and differentiation block in myeloid precursors and ultimately promoting leukemogenesis. Enasidenib (formerly AG-221) is an oral small molecule selective targeted inhibitor of the mutant IDH2 enzyme, approved in August 2017 by the United States Food and Drug Administration for the treatment of patients with relapsed or refractory (R/R) IDH2-mutated AML. Preclinical studies showed the effectiveness of enasidenib in inhibiting the production of 2-hydroxyglutarate with high potency, and alleviating the mutant IDH2-induced differentiation block. In the original AG221-001 phase I/II trial, patients with R/R AML were treated with enasidenib single agent therapy at escalating doses up to 650 mg daily, with the 100 mg dose level identified to be safe and effective for further evaluation. Overall, 113 patients were treated in the dose-escalation and 126 in the dose-expansion cohorts. The overall response rate for R/R patients was 40%, including a complete remission of 19%. At a median follow up of 7.7 months, the median overall survival was 9.3 months, and reached 19.7 months in responders. Enasidenib was well tolerated, although adverse events of clinical interest include indirect hyperbilirubinemia and IDH-inhibitor-induced differentiation syndrome, which can be life threatening if not identified and treated promptly. Ongoing clinical trials evaluating enasidenib in combination with intensive chemotherapy and hypomethylating agents in newly diagnosed AML, and in rational combinations for R/R AML patients are underway.
Myoepithelial carcinoma of the parotid gland: A case of adequate fine-needle aspiration cytology specimens rendering a conclusive diagnosis possible
Authors: Guo Xin , Watanabe Jiro , Ariyasu Sanae , Sasaguri Yasuyuki , Kurose Nozomu , Fukushima Kei , Yamada Sohsuke
Published: June 2018

An 80-year-old male presented with a history of a hard right parotid mass that had gradually increased in size, with subsequent facial paralysis. A fine-needle aspiration biopsy was performed. The cytologic specimens contained a substantial number of sheet-like clusters or small groups of a mixture of plasmacytoid, oval to spindled, or large epithelioid cells having hyperchromatic pleomorphic nuclei, abundant cytoplasm with occasional inclusion body-like materials, and prominent nucleoli, in a relatively clear background. We first interpreted it as a carcinoma, suggestive of myoepithelial differentiation. Radical parotidectomy was performed, and a gross examination of the neoplasm revealed a non-capsulated and ill-defined tumor lesion, with a grayish or yellowish cut surface, associated with fat invasion. On a microscopic examination, the tumor was predominantly composed of the solid proliferation of atypical cells including a mixture of oval to spindled, plasmacytoid, or epithelioid cells, often arranged in a trabecular and reticular growth pattern with patchy eosinophilic hyalinized stroma. Immunohistochemistry showed that the carcinoma cells were specifically positive for p63, cytokeratins, and vimentin. Finally, electron microscopy demonstrated that their phenotype was consistent with a myoepithelial origin containing many bundles of variably thin actin filaments. Therefore, we finally made a diagnosis of myoepithelial carcinoma, defined as the malignant counterpart of benign myoepithelioma. We should be aware that owing to its characteristic cytological features, cytopathologists may be able to make a correct diagnosis of myoepithelial carcinoma, based on multiple and adequate samplings.
The Impact of Fashion Involvement and Pro-Environmental Attitude on Sustainable Clothing Consumption: The Moderating Role of Islamic Religiosity
Authors: Razzaq Ali , Ansari Nabeel Younus , Razzaq Zohaib , Awan Hayat Muhammad
Published: June 2018

There is a general belief that fashion involvement leads toward unsustainability. To resolve this issue, the present study aims to explore that whether sustainable fashion consumption is characterized by an individual’s fashion consciousness and his pro-environmental attitude or not. In addition, how an individual’s religiosity can moderate this relationship. For the purpose of collecting the data, a survey questionnaire method was applied by making use of adopted measurement scales from the previous literature. Convenience sampling technique was employed to collect the data from a total of 350 respondents. The outcomes of this study illustrate that both fashion-conscious and pro-environmental attitude consumers are significantly and positively associated with sustainable fashion consumption. Furthermore, both the aspects of religiosity, that is, interpersonal religiosity and intrapersonal religiosity, moderate the relationship. The current study has profound implications for fashion retailers and manufacturers that they should incorporate sustainable business practices into their manufacturing processes. Managers should focus on devising such a comprehensive business model that is based on the principles of sustainability.
A Model of the Intersection of Pain and Opioid Misuse in Children and Adolescents
Authors: Dash Genevieve F. , Wilson Anna C. , Morasco Benjamin J. , Feldstein Ewing Sarah W.
Published: June 2018

Despite being a significant public health concern, the role of opioid prescriptions in potentiating risk of opioid misuse in the context of pediatric pain has been underinvestigated. To address this gap, the present review identifies theory-based hypotheses about these associations, reviews the extant literature on opioid prescriptions that supports these hypotheses, and provides routes for future empirical studies. A multilevel model of mechanisms through which opioid prescriptions may impact pain and other negative outcomes in youth, including risk for opioid misuse and related problems, is proposed with particular attention paid to the role that psychologists can play in informing policies and developing preventative interventions in healthcare settings.
Globalization and the Peasantry in the South
Authors: Patnaik Prabhat
Published: June 2018

The first Sam Moyo lecture was delivered in Harare, Zimbabwe, on 16 January 2018, in the course of the Annual Agrarian Summer School organized by The Sam Moyo African Institute of Agrarian Studies and the Agrarian South Network. The lecture addresses the character of the peasantry under contemporary imperialism and the challenges it faces against the on-going primitive accumulation of capital. It is argued here that a modified definition of the peasantry is necessary today, as well as a new approach to development that guarantees decent work and access to social services, while also promoting peasant cooperatives towards autonomous industrial development. This, in turn, requires an understanding of capitalism as obsolete and a national project of delinking from globalization, in the transition to socialism.
HSP110 sustains chronic NF-κB signaling in activated B-cell diffuse large B-cell lymphoma through MyD88 stabilization
Authors: Boudesco Christophe , Verhoeyen Els , Martin Laurent , Chassagne-Clement Catherine , Salmi Leila , Mhaidly Rana , Pangault Céline , Fest Thierry , Ramla Selim , Jardin Fabrice , Wolz Olaf-Oliver , Weber Alexander N. R. , Garrido Carmen , Jego Gaetan
Published: June 2018

Key Points

HSP110 sustains chronic NF-κB signaling in ABC-DLBCL through MyD88 stability. HSP110 is highly expressed in cells of patients with ABC-DLBCL and correlates with MyD88 expression.
Carbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS)
Authors: Koppe Uwe , von Laer Anja , Kroll Lars E. , Noll Ines , Feig Marcel , Schneider Marc , Claus Hermann , Eckmanns Tim , Abu Sin Muna
Published: June 2018

Background

Carbapenem resistance in Klebsiella pneumoniae is of significant public health concern and recently spread across several countries. We investigated the extent of carbapenem non-susceptibility in K. pneumoniae isolates in Germany.

Methods

We analysed 2011–2016 data from the German Antimicrobial Resistance Surveillance (ARS) System, which contains routine data of antimicrobial susceptibility testing from voluntarily participating German laboratories. Klebsiella pneumoniae isolates tested resistant or intermediate against an antibiotic were classified as non-susceptible.

Results

We included 154,734 isolates from 655 hospitals in the analysis. Carbapenem non-susceptibility in K. pneumoniae isolates was low in Germany 0.63% (95% CI 0.51–0.76%). However, in continuously participating hospitals the number of K. pneumoniae isolates almost doubled and we found evidence for a slowly increasing trend for non-susceptibility (OR = 1.20 per year, 95% CI 1.09–1.33, p < 0.001). Carbapenem non-susceptibility was highest among isolates from patients aged 20–39 in men but not in women. Moreover, carbapenem non-susceptibility was more frequently reported for isolates from tertiary care, specialist care, and prevention and rehabilitation care hospitals as well as from intensive care units. Co-resistance of carbapenem non-susceptible isolates against antibiotics such as tigecycline, gentamicin, and co-trimoxazole was common. Co-resistance against colistin was 13.3% (95% CI 9.8–17.9%) in carbapenem non-susceptible isolates.

Conclusion

Carbapenem non-susceptibility in K. pneumoniae isolates in Germany is still low. However, it is slowly increasing and in the light of the strong increase of K. pneumoniae isolates over the last year this poses a significant challenge to public health. Continued surveillance to closely monitor trends as well as infection control and antibiotic stewardship activities are necessary to preserve treatment options.
NS1‐binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c‐Myc
Authors: Wang Yuwen , Cheng Jingjing , Xie Dan , Ding Xiaofeng , Hou Hailing , Chen Xi , Er Puchun , Zhang Furong , Zhao Lujun , Yuan Zhiyong , Pang Qingsong , Wang Ping , Qian Dong
Published: June 2018

Background

Cisplatin‐based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma (ESCC). NS1‐binding protein (NS1‐BP), a member of the BTB‐kelch protein family, has been shown to inhibit the proliferation of Hela cells by suppressing c‐Myc. In the present study, we examined the potential function role of NS1‐BP expression in ESCC, and particularly, the sensitivity of ESCC to radiotherapy.

Methods

NS1‐BP expression was examined using immunohistochemistry in two cohorts (n = 98 for the training cohort; n = 46 for independent validation cohort) of ESCC patients receiving cisplatin‐based chemotherapy and concurrent radiotherapy. Normal esophageal mucosal tissue blocks were used as a control. We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over‐expressing NS1‐BP on ESCC cells, and particularly their sensitivity to ionizing irradiation.

Results

In the training cohort, NS1‐BP downregulation was observed in 59% (85/144) of the ESCC specimens. NS1‐BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease‐specific survival (DSS) in both the training and validation cohorts. Over‐expressing NS1‐BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo. NS1‐BP also significantly enhanced IR‐induced apoptosis, and abrogated IR‐induced G2/M cell‐cycle arrest and ATM/Chk1 phosphorylation. Immunoprecipitation assays indicated that NS1‐BP could interact with c‐Myc promoter regions to inhibit its transcription. In ESCC tissues, c‐Myc expression was inversely correlated with NS1‐BP levels, and was associated with a shorter DSS.

Conclusions

Our findings highlight the role and importance of NS1‐BP in radiosensitivity of ESCC. Targeting the NS1‐BP/c‐Myc pathway may provide a novel therapeutic strategy for ESCC.
Expanding the horizons of microRNA bioinformatics
Authors: Huntley Rachael P. , Kramarz Barbara , Sawford Tony , Umrao Zara , Kalea Anastasia , Acquaah Vanessa , Martin Maria J. , Mayr Manuel , Lovering Ruth C.
Published: June 2018

MicroRNA regulation of key biological and developmental pathways is a rapidly expanding area of research, accompanied by vast amounts of experimental data. This data, however, is not widely available in bioinformatic resources, making it difficult for researchers to find and analyze microRNA-related experimental data and define further research projects. We are addressing this problem by providing two new bioinformatics data sets that contain experimentally verified functional information for mammalian microRNAs involved in cardiovascular-relevant, and other, processes. To date, our resource provides over 4400 Gene Ontology annotations associated with over 500 microRNAs from human, mouse, and rat and over 2400 experimentally validated microRNA:target interactions. We illustrate how this resource can be used to create microRNA-focused interaction networks with a biological context using the known biological role of microRNAs and the mRNAs they regulate, enabling discovery of associations between gene products, biological pathways and, ultimately, diseases. This data will be crucial in advancing the field of microRNA bioinformatics and will establish consistent data sets for reproducible functional analysis of microRNAs across all biological research areas.
Assessment of hydrocarbons subsoil and groundwater pollution in a refinery occupied property at the old industrial zone of Athens - Pireaus, Greece
Authors: Zotiadis V. , Kollios A.
Published: June 2018

Industrial activities that took place in the old industrial zone of Athens-Piraeus widespread pollution in natural systems. This specific environmental site assessment presents subsoil and groundwater pollution data by petroleum hydrocarbons in a property occupied by a small scale refinery the last 50 years. Additionally the vertical distribution and horizontal variability of pollution is analysed as a result of several point sources existence such as underground storage tanL·. Environmental survey site works conducted by boreholes performance and installation of stand-pipe type piezometers for groundwater monitoring. Totally 32 soil core samples were analyzed for total petroleum hydrocarbons and additionally 4 soil core sub-samples where volatile organic compounds maximum values were recorded, analyzed for aromatic hydrocarbons. Petroleum hydrocarbons values in subsoil and groundwater range from 310 to 8130 mgKg1 and 0.6 to 2550 mg/l respectively. This paper provides hydrocarbons pollution data of the site and demonstrates the need for an environmental site assessment study before any investment and development action takes place in brownfield's areas
A tale of traded specimens, or what to know when selecting types from Ernst Ule’s collections
Authors: Borges Leonardo M. , Schultz Matthias , Poppendieck Hans-Helmut , Kalhinki Jacquelyn A. , Trovó Marcelo
Published: June 2018

Many Brazilian plant names are based on specimens gathered by European naturalists working in the 19th and early 20th centuries. Among these explorers is Ernst Ule, a German naturalist who collected profusely in Brazil. Ule’s specimens were largely used to publish names before the need to indicate types for valid publication and, hence, many of those names need to be typified. Because typification is not always a straightforward process, we use examples from Mimosa and Paepalanthus to show how an understanding of the historical background of these collections is necessary to support nomenclatural work with names based on specimens he gathered. We present a set of guidelines for typification of names based on his collections and, as examples, we provide lectotypifications for 35 species of Mimosoid legumes.
Male guilt – and shame-proneness: The Personal Feelings Questionnaire (PFQ-2 Brief)
Authors: Rice Simon , Kealy David , Treeby Matt , Ferlatte Olivier , Oliffe John , Ogrodniczuk John
Published: June 2018

Aim of the study

Extant research points to shame and guilt as salient affective experiences for men’s mental health outcomes. As the constructs of shame and guilt gain increasing research attention in relation to at-risk men, including those with recent military combat experience, history of sexual abuse, substance misuse, and suicidality, valid and reliable assessment is needed. The present psychometric validation studies aimed to validate a short-form of the Personal Feelings Questionnaire (PFQ-2) for assessing guilt and shame.

Subject or material and methods

Data was collected from four independent samples of men (total N=1,042) across community and clinical populations.

Results

In Study 1a (n=333) the factor structure of the original 16-item PFQ-2 was rejected. In Study 1b (n=332), a seven-item PFQ-2 Brief was calibrated. This was validated using confirmatory factor analysis in Study 1c (n=335; CFI=.986, TLI=.978, RMSEA=.060, SRMR=.026). Finally, PFQ-2 Brief properties were evaluated in 42 men attending outpatient psychiatric care.

Discussion

The PFQ-2 Brief appears to provide a valid and reliable measure for assessing guilt- and shame-proneness in men.

Conclusions

Use of the PFQ-2 Brief should aid further investigations of the manner in which these two affect styles impact help-seeking, treatment engagement, treatment outcomes, and men’s overall mental health.
Tłumacz i człowiek teatru: Jan Nepomucen Kamiński (1777-1855)
Authors: Eberharter Markus
Published: June 2018

Translator and a Theatre Man: Jan Nepomucen Kamiński (1777-1855)The article characterizes Jan Nepomucen Kamiński as a translator and seeks to determine how important to him was his translation work compared to his other activities (e.g. he is mostly known as the director of the Polish theatre in Lviv). Kamiński’s way to becoming a translator is presented, as well as his socialization in languages and literature. Furthermore, the article gives more detailed information about the translations of Schiller, because Kamiński is mainly known as a translator of this German author. Finally, Kamiński’s conception of translation is discussed, based on the lyrical reflections „O tłómaczeniu” [About translation].

https://doi.org/10.12797/MOaP.24.2018.39.03
(Nie)typowa rola tłumacza starożytnych tekstów dramatycznych
Authors: Bibik Barbara
Published: June 2018

(Non)typical Role of the Ancient Greek Tragedies’ Translator Ancient Greek tragedies were written by their authors to be performed on the Athenian stage and the shape of this stage with its technical devices was included in characters’ lines. However, there is a fundamental difference between the stage those plays were written for and the modern stage on which any drama translation may potentially be realized. The time span too poses a great difficulty for a translator as those plays belong to a culture we probably cannot truly access any more. According to Jerzy Ziomek, every text from the past needs to be adapted nowadays. But does it mean that a translator of any ancient drama aware that those plays were written to be performed on stage, can for various reasons, whether literary or theatrical, take on the role not only of the first reader, but also of the first producer of a given play, thus adapting it to the modern theatre stage?
Medications at home
Authors: Payne Drew
Published: June 2018

This article looks at practical ways to support patients with oral medication compliance in their own homes. It addresses the importance of assessing why the patient needs support, the importance of a medication review and strategies and tools to aid patient compliance, alongside instances where a nurse can aid patient's relatives and carers can provide medication instead of a nurse.
Do not attempt resuscitation orders in primary care settings
Authors: Griffith Richard
Published: June 2018

A Do Not Attempt Resuscitation notice (DNACPR) is an important mechanism for avoiding inappropriate CRP attempts, and protects district nurses and others from allegations of ill treatment or wilful neglect. The DNACPR notice must be discussed with the patient or their relatives, before placed on file ( Tracey v Cambridge Uni Hospital NHS Foundation Trust and others [2014] ; Winspear v City Hospitals Sunderland NHSFT [2015] ). In this article Richard Griffith set out the steps district nurses must take to ensure that a DNACPR notice is lawful.
I want to break free…
Authors: Allingham Sue
Published: June 2018

Without my deliberately looking for them, the news update this month once again contains items about mental health issues. And not just for the children. There are many reasons for this.
Taking the three steps to inspirational leadership
Authors: Smith Kimberly
Published: June 2018

This article will walk you through the three-step approach I took, with the settings and schools I worked with, in order to feel confident and inspired to be the champions who can do what is best for the children.
Give and take: Reciprocity
Authors: Brown Paula
Published: June 2018

Reciprocity is the practice of exchanging things with others for mutual benefit and, as such, is a fundamental part of social interaction, but what does this mean for children in the early years and how can we promote collaboration and altruistic practices?
Stressed? What about the children
Authors: Hamilton Lucie
Published: June 2018

Reports suggest that today's children are experiencing greater levels of stress than at any time, and when coupled with reports that being young in the UK leaves a lot to be desired, it is clear we need to act.
Reconceptualising professionalism
Authors: Dubiel Jan
Published: June 2018

The role of the practitioner, as well as being incredibly important, is also inordinately complex. We work in an environment and a profession that is simultaneously challenging on a multitude of levels.
Care pathways for low-risk transient ischaemic attack
Authors: Bulger Jenna K , Ali Khalid , Edwards Adrian , Ford Gary , Hampton Chelsey , Jones Charlene , Moore Chris , Porter Alison , Quinn Tom , Seagrove Anne , Snooks Helen , Rees Nigel
Published: June 2018

Background:

In secondary care, the urgency of review for transient ischaemic attack (TIA) has relied upon the use of the ABCD2 score, but this tool is not validated for use by emergency ambulance crews. There is a need to evaluate alternative care pathways for patients who might be eligible for direct referral to TIA clinics without prior conveyance to the emergency department (ED).

Aim:

The aim of this national survey was to describe current service provision across the UK for pre-hospital emergency care of patients with TIA.

Methods:

The authors approached all UK Ambulance trusts (n=13) by email, asking them to provide details of TIA patient referral pathways.

Findings:

Twelve ambulance services responded to the survey and nine reported that they had no current pathway; one had discontinued a pathway because of service reconfiguration; and three were currently using one. All pathways used the ABCD2 tool to screen patients and classified patients as low-risk if the ABCD2 score was 3 or below. Non-conveyance exclusion criteria varied. Although compliance with referral pathways was audited in an initial pilot in one service, no other evaluations of the effectiveness of pathways were reported.

Conclusion:

A minority of UK ambulance services report introducing referral pathways for low-risk TIA patients, avoiding initial assessment in the ED. Safety, effectiveness and acceptability of such pathways have not been evaluated to date.
New media, diasporic identity and social exclusion: A study of everyday practices of identity negotiation among second-generation Ghanaian women in Hamburg
Authors: Sanyu Ann Mabel
Published: June 2018

This article focuses on new media use of second-generation Ghanaian women living in Hamburg to negotiate a diasporic identity, drawing from empirical findings of a larger study on Ghanaian women’s use of new media to negotiate identity and belonging in Hamburg and London. Using the non-media-centred approach to contextualize new media use with other social and cultural processes in everyday life. The article argues that whereas new media open up possibilities of maintaining communication networks in the face of social exclusion there is a need to consider other social and cultural processes. The article addresses the role of new media in negotiating diasporic identity through communication, and alternative representation as a means of exerting agency, and empowering a diasporic identity in the face of social exclusion.
Women’s political activism in Iraq: Caught between NGOization and the struggle for a civil state
Authors: Ali Zahra
Published: June 2018

This article explores Iraqi women’s political activism since 2003. It focuses on an in-depth ethnography of women’s political organizations conducted mainly in Baghdad, and in Erbil, Sulaymaniyah, Najaf-Kufa, Karbala and Nasriya. I will start by considering the relationship between gender and the notion of NGOization in Iraq. Secondly, I explore some of the aspects characterizing the post-2003 context and its concrete impact on women’s lives and activism. I look specifically at the issue of the funding of civil society organizations and the ways in which Iraqi women activists deal with the political situation imposed by the US-led invasion and occupation. Finally, the article presents the different forms taken by women’s political activism from their NGOs to their participation in the recent protest movement launched in the summer 2015 questioning the ethno-sectarian and dysfunctional nature of the post-invasion Iraqi regime.
Review
Authors: Mostafa Dalia Said
Published: June 2018

The Lavender Snatcher: A Memoir (Original Arabic Title: Sariq al-Lavender), Nesreen Melek (2016) Beirut: Dar al-Jadid, ISBN 978-9953-11-117-9, 160 pp., US$5.00
Molecular structure, NBO analysis, ï¬rst hyper polarizability, and homo-lumo studies of Ï€-extended tetrathiafulvalene (EXTTF) derivatives connected to Ï€-nitro phenyl by density functional method
Authors: Abbaz Tahar , Bendjeddou Amel , Villemin Didier
Published: June 2018

In these study we have been obtained the structural properties of (exTTF) derivatives 1-4 by using B3LYP/6-31G(d,p) of Density Functional Theory (DFT) utilizing Becke three exchange functional and Lee Yang Paar correlation functional. The calculation of ï¬rst hyperpolarizability shows that the molecules are attractive molecules for future applications in non-linear optics. Molecular electrostatic potential (MEP) at a point in the space around a molecule gives an indication of the net electrostatic effect produced at that point by the total charge distribution of the molecule. The calculated HOMO and LUMO energies show that charge transfer occurs within these molecules.Â
Environmental Impact Assessment: Integrated Evaluation of Bridge Construction Project in Bangladesh
Authors: Hasan Irteja , Shaha Milton , Shafiqul Islam Md , Sirajul Islam Md , Solayman Md , Hossen Miraz , Humayun Kabir Md
Published: June 2018

Environmental Impact Assessment (EIA) may provide a mechanism for executing sustainable development and it is also becoming a very significance revision before authorizing of any project plan. EIA helps to decision making process whether the project is beneficial or harmful effects for the environment. Both on site and off site environmental impacts can be reduced through undertaking EIA for any bridge construction activities. This paper mainly concentrates on to find out potential environmental impact during the construction, operation and maintenance phase of the project using different matrix method. It also finds out the effective mitigation measures of the adverse impacts that will be helpful for the surrounding environment. Primary data were collected from field survey, focus group discussion. Most of the impacts and other consequences are identified based on public perception and the interview of the key personnel’s. Secondary data were also collected for conducting the research. The study found that the bridge is connecting three regions (Bauphal, Patuakhali and Barisal) and it will be a great achievement for the local coastal community. This new bridge project will not only increase the communication facilities but also other facilities such as economic flow, medical facilities etc. The EIA study founds some major negative Impacts such as loss of land and resettlement, loss of aquatic habitat, loss of local trees varieties, loss of agricultural lands, loss of vegetation, potential impact on ecological resources, impact on fish migration etc. But analyzing the overall impact of the environment, the EIA study found that that the possible negative impact is not so high and the project can be implemented. Different environmental management plans are suggested for reducing the potential negative impact of the bridge construction project.
Changing Faces - Factors Influencing the Roles of Researchers in Real-World Laboratories
Authors: Hilger Annaliesa , Rose Michael , Wanner Matthias
Published: June 2018

In real-world laboratories (RwLs), researchers do more than conventional research. They slip into different roles. Why do they “change faces”? Based on comparisons of three urban RwLs, we analyse the process steps and conditions influencing the choices made by researchers
to adopt certain roles.Real-world laboratories (RwLs) often put researchers in highly demanding research contexts regarding their roles and self-conceptions. Helpful roles of researchers have been described but still little is known about the factors influencing the adoption of certain
roles. Using data from three parallel RwLs in Wuppertal, Germany, we found four roles of researchers: the reflective scientist, the facilitator, the change agent and the (self-)reflexive scientist. We sequenced the RwLs into situations and analysed them by RwL process
steps and conditions, considering the roles of researchers as outcomes. Although the conditions convey only limited explanatory power, there was a consistent picture that being pressured to carry out real-world action, having a practice partner with fewer resources and working without a functional
project group is (in conjunction) sufficient to cause the researcher to partake in activities beyond conventional research. Process steps played a minor role. Our research on factors influencing the adoption of roles may help RwL researchers to perform their roles as intended.
The effect of leader-member exchange on job performance of academic staff: An empirical evidence from higher education institutions
Authors: Duyan Mehdi , Yıldız Süleyman Murat
Published: June 2018

Recently, the relationship between leader-member exchange and job performance has become more interesting subject among researchers. However, the literature has a paucity of empirical studies conducted in the higher education institutions; therefore, the relationship between these two variables is not clear. Hence, the purpose of this study was to examine the effect of leader-member exchange on the job performance of academic staff in higher educational institutions. The data for the study were collected from the academic staff (n=174) of five faculties of sport sciences in Turkey. The LMX-7 scale developed by Scandura and Graen (1984) was used to determine the quality of the interactions between leaders (i.e., administrators) and members (i.e., academic staff). Sigler and Pearson’s (2000) job performance scale, which is a modified version of Kirkman and Rosen’s (1999) team productivity scale, was used to measure job performance. The findings exposed a statistically significant positive effect of leader-member exchange on job performance (p<0.05).
Population genetic subdivision of seagrasses, Syringodium isoetifolium and Thalassia hemprichii, in the Indonesian Archipelago
Authors: Wainwright Benjamin J. , Arlyza Irma S. , Karl Stephen A.
Published: June 2018

The population genetics of two seagrasses,Syringodium isoetifoliumandThalassia hemprichiiwere assessed throughout the Indonesian Archipelago. We genotyped 257 blades ofS.isoetifoliumat 15 microsatellite loci collected from 14 sampling sites and 406 blades ofT. hemprichiiat 17 microsatellite loci from 16 sampling sites. Once clones were removed, 165 individuals ofS.isoetifoliumand 389 ofT. hemprichiiwere used in downstream analyses. Bayesian clustering methods revealed two genetically distinguishable clusters in each species, although the geographic boundaries of these clusters differed.Syringodium isoetifoliumhas a cluster that is located exclusively on the shallow Sunda Shelf and appears to follow the demarcation defined by Wallace’s line.Thalassia hemprichii, however, has a genetically distinguishable cluster located within the Banda Sea. The Banda Sea has unique physical oceanographic conditions, which may be driving the observed differentiation inT. hemprichii. We speculate that historical sea level changes exposing the Sunda Shelf, and the unique oceanographic conditions of the Banda Sea are contributing to the observed population differentiation. The observed genetic differentiation in both species is a possible starting point for speciation.
Can water temperature impact litter decomposition under pollution of copper and zinc mixture
Authors: Pu Gaozhong , Tian Xingjun
Published: June 2018

To better understand the impact of warming on heavy metals (HM) associated with plant litter decomposition in streams, we investigated the impact of high and low HM (Cu and Zn) levels and different water temperatures (10,15 and 20oC) on microbial decomposition ofTyphaangustifoliaL.litter and the associated extracellular enzyme activities. During a 100-day incubation, changes in litter mass losses, chemical composition (lignin and total carbohydrate), and extracellular enzyme activity were determined. The decomposition rates were accelerated by the low HM levels at 20oC (0.0051 day–1at CKvs0.0061 day–1at low HM levels). The negative effects of Cu and Zn onTyphalitter decomposition were more pronounced at lower temperatures (10 and 15°C). The enhanced enzyme activities of cellulase and β-glucosidase and the higher lignin/litter weight loss and lignin/carbohydrate ratios were found at 20oC and low HM treatment. The enzyme activities of β-glucosidase and cellulase were positively correlated with litter mass losses at 20oC and low HM levels. These results suggest that a 5oC increase in water temperature may attenuate the inhibition of low HM level on litter decomposition.
Analysis of Metabolites in Cabernet Sauvignon and Shiraz Dry Red Wines from Shanxi by1H NMR Spectroscopy Combined with Pattern Recognition Analysis
Authors: Zhu Jiangyu , Hu Boran , Lu Jie , Xu Shaochen
Published: June 2018

Metabolomics technology based on proton nuclear magnetic resonance (1H NMR) spectroscopy combined with pattern recognition analysis was used to characterize the Cabernet Sauvignon and Shiraz dry red wines vinified in the Linfen of Shanxi Province, China, in 2016. The results showed that there was a very significant difference between the metabolites of Cabernet Sauvignon and Shiraz dry red wines from the area of Linfen. Compared with Shiraz dry red wines, Cabernet Sauvignon dry red wines contained higher levels of proline, valine, tartaric acid, citric acid, malic acid, gallic acid, β-glucose and ethyl acetate, whereas 2,3-butanediol, lactic acid, choline, glycerol, α-D-glucuronic acid, succinic acid and alanine were present in lower levels. Application of NMR spectroscopy combined with pattern recognition analysis showed the discriminative power between wine varietals from the same production area. The loading plot from partial least squares discriminant analysis (PLs-DA) indicated that the key biomarkers for this differentiation were proline, tartaric acid, glycerol, lactic acid, choline, succinic acid and gallic acid, which was consistent with the result of quantitative analysis.
The risks associated with falling parts of glazed facades in case of fire
Authors: Sędłak Bartłomiej , Kinowski Jacek , Sulik Paweł , Kimbar Grzegorz
Published: June 2018

Arguably, one of the most important requirement a building have to meet in case of fire is to ensure the safe evacuation of its users and the work of rescue teams. Consequently, issues related to the risks associated with falling parts of facades are fairly well known around Europe. Even though not equally well defined as other fire safety requirements concerning glazed facades, there is plenty of test methods for assessment of facades regarding falling parts, mostly based on an approach related to fire spread. In this paper selection of test method for assessment of facades regarding falling parts is briefly presented. However, focus of this work is on fire test of typical glazed segment of façade performed in ITB Laboratory. Results of the test positively verifies conjecture that solutions with glass units configured with thin, tempered glass panes on the outer side should pose no threat. However, the question has been raised whether the behaviour of other glass unit solutions (with additional coatings or laminated) would be similar.
A logical specification language for ontologies in the system “Binary Model of Knowledge”
Authors: Plesniewicz Gerald , Karabekov Baurzhan , Masherov Dmitry
Published: June 2018

We describe the language LLS-1 for logical specifying ontologies written in “Binary Model of Knowledge” (BMK). BMK is the system intended for specifying heavy-weight ontologies by means of conceptual-type languages. The language LLS-1 has a user-friendly syntax in style of the Manchester syntax for OWL. We also determine a deduction method for LLS-1.
Firm Heterogeneity, Imported Input Quality, and Export Pricing in India
Authors: Anderson Michael A. , Davies Martin , Signoret Jose E. , Smith Stephen L. S.
Published: June 2018

Using a novel dataset we examine the pricing behavior of Indian exporters, in particular looking at the relationship between export prices and the quality of imported inputs that firms use, conditioning on firm capability (productivity). Exporting firms that directly import are different in important ways from exporters that do not import directly. Among directly importing exporters, higher quality (higher price) imports are associated with higher quality (higher price) exports. In this respect, Indian exporters behave similarly to other developing country exporters, offering suggestive evidence of the importance for export success of access to high-quality imports.
The Usefulness of Near-Infrared Spectroscopy in Monitoring the Location of Eloquent Area and Function Preservation in Brain Surgery
Authors: Goto Tetsuya , Ndubuisi Chika , Kobayashi Tatsuya , Kiuchi Takafumi , Kodama Kunihiko , Sakai Keiichi , Hongo Kazuhiro
Published: June 2018

The extent of resection has been shown to influence the outcome of brain tumours. The concept of brain plasticity is to prevent damage to the eloquent areas while maximizing the extent of tumor resection. The present case report describes the usefulness of the near-infrared spectroscopy (NIRS) in evaluation of the possibility of functional preservation for surgeries in eloquent areas. We present a 46-year-old woman, who had previously undergone four sessions of internal decompression surgery for left frontal anaplastic ependymoma. She later underwent radical tumor resection surgery involving the superior and middle frontal gyri, anterior parietal gyrus, corpus callosum, coronal radiation and basal ganglia. Postoperatively, her right hemiparesis did not deteriorate and she could ambulate without much aid. Multichannel NIRS system revealed that hot spot location was in the right superior frontal gyrus and parietal lobe by the same task of right knee joint movement. We judged that her right brain motor function shifted to the contralateral hemisphere by the long course of her illness. It might be possible that if the NIRS was used earlier around the third or fourth perioperative period, with a reliable confirmation of migration of the right motor function to opposite side, the option of a more aggressive tumor resection may have been attempted. NIRS can be a useful and sensitive tool for predicting the location of eloquent areas and monitoring the extent of brain plasticity between surgeries.
Surgical Clipping vs Endovascular Coiling for Newly Diagnosed and Recurrent Cerebral Aneurysms: an Update on the Current Literature. Single-Center Case Series
Authors: Salle F. , Jaume A. , Castelluccio G. , Spagnuolo E.
Published: June 2018

The ideal treatment for intracranial aneurysms has been highly controversial in the last few decades. It is particularly difficult to decide between clipping vs. coiling when it comes to an aneurysm that has already been treated. The authors performed a review of the literature published in the last ten years amongst the main neurosurgical publications and make recommendations based on this evidence and the surgical experience of the eldest author of this paper (ES). A series of cases of recurrent, incompletely coiled aneurysms treated with surgery is presented. Conclusions: aneurysms with a convenient configuration and location for either clipping or coiling might be better managed by surgical clipping in young patients considering that this treatment achieves higher rates of occlusion with a lower incidence of rebleeding. In elderly patients, each case must be discussed.
Early Results of Microsurgical Treatment of Acromegaly
Authors: Ajler Pablo , Campero Alvaro , Landriel Federico , Goldschmidt Ezequiel , Hem Santiago , Carrizo Antonio
Published: June 2018

Purpose

Acromegaly is an unusual disorder caused by abnormal oversecretion of growth hormone by pituitary adenomas. Transsphenoidal surgery is frequently the first management option. The objective of this article is to establish the effectiveness of a transnasal transsphenoidal approach in the treatment of GH-producing adenomas, and to identify risk factors for disease persistence.

Methods

We conducted a retrospective review of 81 patients treated for acromegaly with transsphenoidal microsurgery between 2006 and 2010.

Results

Macroadenomas accounted for 66.7% of the cases, contrast-enhanced MRI revealing cavernous sinus invasion in 28.4% of the patients (23 subjects). Cure was achieved in 72.8% (59 of 82). All microadenomas (27 cases) were managed effectively with surgery whereas cure rates stood at 66.7% for macroadenomas. Monovariate analysis showed that disease persistence was statistically associated with three variables. Odds ratio for remission stood at 1.68 for microadenomas and 0.033 for cavernous sinus invasion (p<0.001). Preoperative GH values were statistically associated with cure during follow up (p<0.05). Multivariate logistic regression analysis showed that only cavernous sinus invasion continued to be significantly associated with disease persistence (OR 3.52, p<0.05).

Conclusion

The transnasal approach proves effective in the treatment and cure of acromegaly. Cavernous sinus invasion is a major predictor of disease persistence.
Declension of the Latin present participle in connection with its syntactico-semantic use
Authors: Walvoort Hendrik Christiaan
Published: June 2018

This paper deals with the declension of the Latin present active participle (ppa), which shows several inconsistencies: the ablative singular for instance may end in -eor in -i(sapiente, sapienti) and the genitive plural may end in -umor -ium(sapientum, sapientium). Some grammarians, notably modern ones, assume that there are syntactico-semantic considerations or circumstances, leading to ablative -eending when verbal force is intended (such as in the ablative absolute) or substantival force, and to -iending when there is nominal, notably adjectival force. I have investigated whether ancient, medieval and modern grammarians treat such a phenomenon. In addition, I looked for inconsistencies in the grammarian’s own ppa declension from this syntactico-semantic point of view. It turns out that ancient and medieval grammarians do not formulate declension of the ppa according to its syntactico-semantic function, with the exception of the anonymous author of theArs Ambrosiana, nor do they decline their own ppa’s according to a conventional rule of this kind. This calls for other explanations regarding the declensional inconsistencies observed. Some of the ppa forms may reflect a temporary phenomenon which would have disappeared in due course through diachronic evolution and paradigm leveling. Some forms may have persisted because of their frequency and idiomatic force or because of the compelling analogy with other words and phrases. But these ppa declensional variations do not appear to conform to a syntactico-semantic rule.
Genetic analysis of three families with X-linked dominant hypophosphatemic rickets
Authors: Lin Xinfu , Zhu Yaobin , Luo Jiewei , Huang Jianbin
Published: June 2018

Background

Hypophosphatemic rickets, including familial hypophosphatemic vitamin D-resistant rickets, which commonly manifests in childhood, is generally hereditary. X-linked dominant hypophosphatemic rickets (XLH, MIM307800), caused by inactivating mutations in the PHEX gene, is the most common form. This study aimed to identify the gene mutations responsible for three cases of XLH and its clinical phenotype.

Methods

We conducted a genetic diagnosis and clinical phenotypic linkage analysis of three pedigrees with XLH. Three probands finally diagnosed as XLH were analyzed by next-generation sequencing (NGS). Sanger sequencing was used for mutation scanning in other family members.

Results

For the three patients with XLH, the age of onset ranged from 1.5 to 2 years and their heights were less than three standard deviations (SDs) below the median. The patients exhibited curved deformities in both lower limbs, hypophosphatemia, elevated serum FGF23 levels and elevated levels of blood alkaline phosphatase, with normal levels of blood parathyroid hormone (PTH) and calcium. X-ray analysis of the limbs and chest revealed characteristic rickets signs. Three candidate pathogenic mutations were identified in PHEX (NM_000444.5): c.433G>T (p.Glu145*, p.E145*) in exon 4, c.1735G>A (p.Gly579Arg, p.G579R) (rs875989883) in exon 17 and c.2245T>C (p.Trp749Arg, p.W749R) in exon 22. The nonsense mutation (p.E145*) in PHEX is novel and is predicted to cause a truncation of the encoded protein, resulting in loss of function.

Conclusions

The novel nonsense mutation (p.E145*) in PHEX is possibly involved in inherited XLH.