bluuebunny/crossref_metadata_2025 huggingface dataset:
KNOWLEDGE AND ATTITUDE OF DENTAL AND ENT PROFESSIONALS TOWARDS PRE-PROCEDURAL USE OF POVIDONE-IODINE MOUTH RINSE DURING COVID -19 -- A QUESTIONNAIRE-BASED CROSS-SECTIONAL STUDY
Authors:   Post Graduate Scholar, Department of Periodontics & Oral Implantology, Govt Dental College & Hospital, Srinagar, J & K, India., Ahmad Janbaz Zubair , Majid Jan Suhail ,   Professor & Head, Department of Periodontics & Oral Implantology, Govt Dental College & Hospital, Srinagar, J & K, India., Behal Roobal ,   Associate Professor, Department of Periodontics & Oral Implantology, Govt Dental College & Hospital, Srinagar, J & K, India.
Published: February 2022

Aims And Objectives: The aim of this study is to assess the knowledge and attitude of dental and ENT Professionals towards Pre-procedural use of Povidone-Iodine Mouth rinse during Covid -19. The latent objective was to revitalize the usage of pre-procedural Povidone iodine rinse in clinical settings for Covid-19 cross infection containment. Material And Methods: A cross-sectional study was carried out in the Post Graduate Department of Periodontics and Oral Implantology, Govt Dental College & Hospital Srinagar, J & K. An online questionnaire was distributed among dental and ENT professionals including Interns, Junior residents, Post Graduate Students, Dental and ENT Surgeons. Online social media platforms were utilized to disseminate the questionnaire. The study had a sample size of 223 participants. Results:39.5% participants were doing pre-procedural mouth rinse of patients before Covid-19 pandemic. Post Covid -19 pandemic, 53.5 % practitioners started doing the pre-procedural mouth rinsing of patients. 51.9 % participants were using PVP-I as pre-procedural mouth rinse,41.3 % of participants were using CHX while as 6.8 % were using any other rinsing agent.52.2 % of participants viewed it as moderately effective in containment of Covid-19 cross infection. 43.5 % of participants considered PVP-I as having higher virucidal activity,26.1 % of participants considered CHX as having higher virucidal activity.30.4 % participants considered Hydrogen peroxide as more effective anti-viral agent than both PVP-I and CHX. Conclusion: There is a dire need to raise awareness amongpractitioners in general and dentists in particular, regardingthe virucidal activity of available mouthwashes as is backed by various in-vitro studies. With the Covid-19 pandemic carving out a new normal, the specialists dealing with aerosol producing procedures need to perform the clinical duties more safely. This would be a shot in the arm in our fight against SARS COV-2 driven pandemic.
IMPACT OF NURSING REHABILITATION PROGRAM ON MINIMIZING POST- BURN JOINT CONTRACTURE
Authors:   Assistant Lecturer in Medical Surgical Nursing Department, Faculty of Nursing -Kafrelsheikh University., Mohsen Mohammed Mohammed , Ismaiel Sherif Wafaa ,   Professor of Medical Surgical Nursing Department, Faculty of Nursing - Mansoura University., Abdelaziz ElRefai Mohga ,   Professor of Medical Surgical Nursing Department, Faculty of Nursing -Kafrelsheikh University., Abo Bakr Mohammed Hanan ,   Assisstant Professor of Medical Surgical Nursing Department, Faculty of Nursing - Mansoura University.
Published: February 2022

Globally, burns are a serious public health problem. Rehabilitation isanessential and basic part of burn treatmentto limit contracture. It isnt something whichhappens following healing of skin grafts or discharge from hospital all things considered a process that beginnings from day one of admission and proceeds for a long time and sometimes years after the initial event. Aim of the current study:The aim of this study was to evaluate the impact of nursing rehabilitation program on minimizing post-burn joint contracture. Research Design: Quasi-experimental pretest, posttest research design was utilized. Setting:The study was conducted in Burn Unit at General Kafrelsheikh Hospital- Kafrelsheikh City- Kafrelsheikh Governorate). Subjects:A purposive sample of 60 adults male and female inpatients diagnosed with major burn injury at shoulder, elbow, hip or knee joint where they included in the study, Patients assigned into two groups (control and study). Tools of data collection: tool 1:Demographic and medical data sheet, tool II: Joint motion measurement scale. Results:most of the study group were suffering contractures with active range of motion compared with more than three quarter of control group. While, about one third of the study have contractures with passive range of motion compared with more than two third of control group.A Statistically significant difference put into evidence between the two groups regarding severity, and frequency of range of motion limitation for affected joints. Conclusion: contractures are common problems after a major burn injury. Number of contractures occurred in spite of receiving a rehabilitation program. Despite the frequency of contractures at time of hospital discharge, very few contractures were severe. Recommendations.Early application of rehabilitation program as an important intervention for minimizing contracture in sever burn patients.
EVALUATION OF EFFICACY OF HIJAMAH BIL SHURT (WET CUPPING) IN MANAGEMENT OF PSORIASIS
Authors:   Specialist, NAM, Government Unani Hospital Shalteng, Srinagar, Jammu and Kashmir, 190017., Mushtaq Allaqaband Shafia , Naqashbandi Farooq ,   Incharge Government Unani Hospital Shalteng, Srinagar, Jammu and Kashmir, 190017., Gowhar Bilal Syed ,   Medical officer, Department of Indian system of medicine, Government of Jammu and Kashmir.
Published: February 2022

Psoriasis is a chronic disorder with impact on quality of life and its high rate of relapse is noted every now and then. The disease of psoriasis has been prevalent in mankind since time immorial and the disease runs a chronic course. Da-us-sadaf (psoriasis) is an Arabic word da meaning disease and as sadaf meaning molluscum shell. Psoriasis is marked by shell like silvery white scales or flakes which keep on shedding from the horny layer of skin. Many eitioathological conditions predispose to psoriasis which includes genetic, environmental and immunological factors. According to Unani system of medicine, preponderance of melancholic humours present in human body is believed to be the cause. The prevalence of psoriasis in India varies from 0.44 to 2.8%. Hijamah (cupping) is one of the oldest method of treatment of Unani system of medicine in with cups are used to produce suction and bloodletting is done from the affected area. During our study cups were applied at interscapular area between the vertebral T1 â€“T3. The study was carried out to evaluate the efficacy of the hijamah bil shurt along with internal use of unani medicine under the principles of holistic approach for the management of disease. The patients of both sexes where included in the study, with average age of 10.5 years and were not getting good relieve from previous medication they used for same. All these patients were subjected to wet cupping at the designated areas and internal use of unani medicine. The patients were subjected to wet cupping after every week in the first month and after every 15 days for two months. After the treatment with hijamah bil shurt and unani medicine the patients got 100% relief from the symptoms of the disease. The study showed that Hijamah bil shurt is very effective in the management of psoriasis along with oral Unani medication.
ANCYLOSTOMA DUODENALE PRESENTED AS SEVERE ANAEMIA: A CASE REPORT IN A TERTIARY CARE CENTRE, NORTH-EAST INDIA
Authors:   Post Graduate Trainee, Department of Microbiology, AGMC & GBP Hospital, Agartala, Tripura., Banik Ashmita , Pratap Dutta Rana ,   Post Graduate Trainee, Department of Microbiology, AGMC & GBP Hospital, Agartala, Tripura., Barman Debasis ,   Associate Professor, Department of Microbiology, AGMC & GBP Hospital, Agartala, Tripura., Majumdar Tapan ,   Professor & HOD, Department of Microbiology, AGMC & GBP Hospital, Agartala, Tripura.
Published: February 2022

Hookworm infections (Necator americanus, Ancylostoma duodenale) are common in rural areas of tropical and subtropical countries. Human get infection from direct percutaneous invasion of infective larva from contaminated soil. The majority of infected patients remain asymptomatic. However, iron deficiency anaemia (IDA) due to chronic blood loss is the major complication. Here we presented a case of iron deficiency anaemia with its relavent history which later on diagnosed as a chronic case of hookworm infection with Ancylostoma duodenale.
The concentration and prevalence of asbestos fibres in Christchurch, New Zealand's drinking water supply
Authors: Mager S. , Knopick M. , Oddy G.
Published: February 2022

Asbestos cement was a common construction material for water pipes during the twentieth century, as a replacement for metal piping that was vulnerable to corrosion. We report on the presence of asbestos fibres in drinking water supply in Christchurch, New Zealand from ageing asbestos cement reticulated water supply. By sampling the mains water supply via hydrants, 19 of our 20 samples showed long asbestos fibres (>10 μm), with an average concentration 0.9 million fibres per litre (MFL). Short asbestos fibres (>0.5 μm) had an average concentration of 6.2 MFL. Sampling was targeted to pipes from 1930 to the 1960s and there was abundant evidence of fibres being released from pipes of this age. Municipalities cannot continue to rely on ageing asbestos-cement piping, as it appears to be releasing asbestos fibres into drinking water with uncertain health implications, and should prioritise replacing pipes greater than 50 years in age, especially where high water pressures or land disturbance occur, to reduce the risk of water-carried asbestos being released into urban environments, and mitigate any risk of asbestos from ingested contaminated water sources.
A coastal reservoir for Greater Sydney water supply in Shoalhaven river – a preliminary study
Authors: Ji Rong , Yang Shu-Qing , Sivakumar Muttucumaru , Enever Keith , Bin Riaz Muhammad Zain , Khalil Usman
Published: February 2022

Australia is the driest inhabited continent on earth, and most of its population is concentrated along the coastal line. In recent years, extreme climate events such as floods and droughts have occurred more frequently. Sydney, as the largest city in Australia, requires a reliable water supply. Many solutions have been conducted to secure its water supply. This paper is focused on future water supply for the Greater Sydney area. The analysis supports the concept that in runoff-rich regions like Greater Sydney, there is no water shortage but a lack of water storage. The novel technology, coastal reservoirs, can increase the storage capacity of freshwater in the sea. The average annual discharge at Shoalhaven River mouth is estimated as 1,334 gigalitres. By comparison, the average annual inflow to the Warragamba Dam, which supplies 80% of Sydney's drinking water, is 1,069 gigalitres. This paper discusses how to apply a Coastal Reservoir at the Shoalhaven River mouth to secure additional water supply for ever-growing Greater Sydney. The proposed reservoir with a capacity of 500 gigalitres could supply 1,000 gigalitres of water per year with a reliability of 90%. A preliminary design of the reservoir is demonstrated.
Research on real-time risk monitoring model along the water transfer project: a case study in China
Authors: Wang Fang , Liu Bing , Li Hongen , He Yongjun
Published: February 2022

With the continuous operation of a water transfer project, especially under the general trend of global climate change in recent years, extreme weather occurs frequently, and the project's operation process will be tested by natural disasters, structural damage, electromechanical equipment failure, water pollution and other risks. Therefore, the risk management of the water transfer project is of great significance to ensure the long-term operation of the project. As one of the four largest cross-century projects in China, the operation risk of the South-to-North Water Transfer Project has attracted great attention. In this paper, a system dynamic model (SDM) for simulating real-time risk is presented. Based on the linear and directional characteristics of water transfer project and the known risk level of single buildings, DYNAMO language is embedded to connect the risks of various points on the line, and a model for real-time monitoring the risk changes along the line is constructed. The what-if analysis performed by the SDM shows the importance of human intervention to the deterioration and spread of dangerous situations in the process of engineering damage.
Nutraceutical Potential of High-latitude and High-altitude Berries Rich in Ellagitannins
Authors: Burlando Bruno , Cornara Laura , Boggia Raffaella
Published: February 2022

Introduction:

This review concerns three species of berries, namely the high- -latitude cloudberry (Rubus chamaemorus) and arctic bramble (Rubus arcticus), and the high-altitude yellow raspberry (Rubus ellipticus). These plants are mostly exploited on a local basis as food or traditional remedies but could have a wider usage as nutraceuticals due to their richness in ellagitannins (ETs) and other phenolic compounds. ETs are hexahydroxydiphenoyl esters of carbohydrates and the largest group of hydrolysable tannins. They are distinctly antioxidant and bioactive compounds, and therefore, are considered as majorly responsible for the biological properties of ET-rich berries. The health benefits of ETs are mainly due to the release of ellagic acid and to their metabolic transformation by the gut microbiota into urolithins, and include, among others, anti-inflammatory, antiviral, anti-bacterial, and anticancer actions.

Methods:

Based on the literature searches in the Web of Science, Scopus, and PubMed databases, ethnobotanical, pharmaceutical, medicinal, and nutritional knowledge concerning the three berry species was covered. This includes empirical use of traditional preparations and experimental studies with various extracts and fractions from fruits and other plant portions, covering in vitro, preclinical, and clinical research.

Results:

The data reveal a wide spectrum of potential uses in health care, providing in some cases an experimental confirmation of traditional uses.

Conclusions:

The examined berry species can act as nutraceutical foods, having positive effects on regular consumers but could also be exploited in more technological ways to produce food complements from ET-rich extracts.
Recent Advances in the Selection of Cancer-Specific Aptamers for the
Development of Biosensors
Authors: Sousa Diana A. , Carneiro Mariana , Ferreira Débora , Moreira Felismina T.C. , Sales Maria Goreti F. , Rodrigues Lígia R.
Published: February 2022

An early diagnosis has the potential to greatly decrease cancer mortality. For
that purpose, specific cancer biomarkers have been molecularly targeted by aptamer sequences
to enable an accurate and rapid detection. Aptamer-based biosensors for cancer
diagnostics are a promising alternative to those using antibodies, due to their high affinity
and specificity to the target molecules and advantageous production. Synthetic nucleic
acid aptamers are generated by in vitro Systematic Evolution of Ligands by Exponential
enrichment (SELEX) methodologies that have been improved over the years to enhance
the efficacy and shorten the selection process. Aptamers have been successfully applied
in electrochemical, optical, photoelectrochemical and piezoelectrical-based detection
strategies. These aptasensors comprise a sensitive, accurate and inexpensive option for
cancer detection being used as point-of-care devices. This review highlights the recent advances
in cancer biomarkers, achievements and optimizations made in aptamer selection,
as well as the different aptasensors developed for the detection of several cancer biomarkers.
Mini review on the synthetic methodology of citric acid functionalized magnetic graphene oxide characterization and its implementation in waste water treatment
Authors: Sharma Shobhana
Published: February 2022

Water is an essential element for day-to-day activities like agriculture, industry and domestic uses, etc for human beings. Now-a-day, water pollution by heavy metal ion is one of the most crucial environmental issues. Various methods like ion exchange, chemical precipitation, coagulation, flocculation, membrane filtration, adsorption, and flotation have been adopted to get rid of heavy metal ions from the waste water. Among all these methods, the adsorption process has been widely used for the elimination of heavy metals due to its environment friendly, cost-effective nature and easier availability. The commercial adsorbents, bioadsorbents, and nanosorbents possess high removal capacity, thus used for the eradication of heavy metals from waste water. In recent years, nanosorbents are used in environmental remediation as it occupies large surface area and high substance specificity. The present review aims to assemble the role of citric acid functionalized magnetic graphene oxide in waste water treatment. The presence of functional groups like citric acid, Fe2O3 on graphene oxide holds ample of sites which lead increase its surface area and enhance its adsorptivity. The magnetic nature of graphene oxide provides good dispersity in water and makes it easily separable.
Current Synthetic Methodologies of Carbon Nanotubes: A Review
Authors: sharma Shobhana
Published: February 2022

Carbon Nanotubes (CNTs) possess a unique one-dimensional molecular geometry with a large surface area. Recently, CNTs have become a thrust area of research as they play a crucial role in molecular engineering due to their excellent mechanical, electrical, and thermal properties. CNTs have a wide range of applications in various fields due to their unique properties. The Multiple Walled Carbon Nanotubes (MWCNTs) are thermally, mechanically, and structurally stronger than single-walled carbon nanotubes (SWCNTs). The sublimation of carbon in an inert atmosphere is the basis of synthetic methods of CNTs like the solar method, laser ablation, and electric arc discharge. Specific chemical methods like CVD, electrolysis, catalytic decomposition of hydrocarbons, heat treatment of a polymer, ball milling, etc., can also be used to prepare CNTs. Attempts have been made in the present review to discuss all synthetic methods of CNTs, their discoverers, the importance of techniques, various parameters that affect the process in detail, and the mechanism for the growth of CNTs. This article aims to provide a comprehensive pathway for researchers who deal with the synthetic methodology of carbon nanotubes. This review is also interesting for readers of material science and nanochemistry.
Effects of Vitamin D Levels on Cardiovascular Diseases: A Systematic
Review
Authors: de Macêdo Gonçalves Frota Karoline , de Lima Sousa Paulo Víctor , Nascimento Larisse Monteles , de Oliveira Amanda Ferreira Mesquita , dos Santos Gleyson Moura , da Silva Moura Alana Rafaela , Primo Maísa Guimarães Silva , de Azevedo Paiva Adriana , de Jesus e Silva de Almendra Freitas Betânia , de Carvalho Cecília Maria Resende Gonçalves , do Carmo de Carvalho e Martins Maria
Published: February 2022

Background:

Cardiovascular diseases (CVDs) are a group of pathologies that involve
heart and blood vessel disorders and are considered the main cause of death in the world. Epidemiological
studies have shown the association between low vitamin D (VD) levels and CVD.
This vitamin, in addition to acting on bone metabolism, plays a role in modulating the cardiovascular
system.

Objective:

The present study assesses the effects of VD levels on CVD through a systematic literature
review.

Method:

For this purpose, the PICO strategy was used to prepare the guiding question, and articles
were searched in the PubMed, Scopus, Science Direct, and Web of Science databases by two
authors independently. To guarantee the quality of the evidence of the articles included in the
review, the Newcastle-Ottawa scale was used. The literature review followed the PRISMA recommendations.

Results:

In this review, 22,757 articles were identified, but only 10 were considered eligible, of
which 70 % are prospective cohorts and 30 % are retrospective cohorts. The study showed that
low 25(OH)D levels correlate with an increased risk of cardiovascular events and death from
CVD, including in patients who had preexisting CVD. However, one article did not demonstrate
this association.

Conclusion:

As a result, VD correlates with cardiovascular events and the risk of death.
Analysis of Novel Variants Associated with Three Human Ovarian Cancer
Cell Lines
Authors: Mekala Venugopala Reddy , Chang Jan-Gowth , Ng Ka-Lok
Published: February 2022

Background:

Identification of mutations is of great significance in cancer research, as it can contribute to development of therapeutic strategies and prevention of cancer formation. Ovarian cancer is one of the leading cancer-related causes of death in Taiwan. Accumulation of genetic mutations can lead to cancer.

Objective:

We utilized whole-exome sequencing to explore cancer-associated missense variants in three human ovarian cancer cell lines derived from Taiwanese patients.

Methods:

We use (i) cell line whole-exome sequencing data, (ii) 188 patients’ whole-exome sequencing data, and (iii) use of in vitro experiments to verify predicted variant results. We establish an effective analysis workflow for discovery of novel ovarian cancer variants, comprising three steps: (i) use of public databases and in-house hospital data to select novel variants (ii) investigation of protein structural stability caused by genetic mutations, and (iii) use of in vitro experiments to verify predictions.

Results:

Our study enumerated 296 novel variants by imposing specific criteria and using sophisticated bioinformatics tools for further analysis. Eleven and 54 missense novel variants associated with cancerous and non-cancerous genes, respectively, were identified. We show that 13 missense mutations affect the stability of protein 3D structure, while 11 disease-causing novel variants were confirmed by PCR sequencing. Among these, ten variants were predicted to be pathogenic, while the pathogenicity of one was uncertain.

Conclusion:

We confirm that novel variant genes play a crucial role in ovarian cancer patients, with 11 novel variants that may promote progression and development of ovarian cancer.
Application of 68Ga-PSMA-11 PET/CT in the Diagnosis of Prostate Cancer Clinical Relapse
Authors: Diego Regina Paula Soares , Rádis-Baptista Gandhi , Filho Ricardo Vale Albino Oliveira , de Albuquerque Estelita Tinoco Branco , de Castro José Daniel Vieira , dos Santos Katyane Moreira , de Lucena Santos Joelan Ângelo , da Silveira Oliveira Guilherme Freire , de Lucena Santos Poliane Ângelo
Published: February 2022

Background:

This work aims to present a nuclear medicine imaging service’s data re-garding applying positron emission–computing tomography (PET/CT) scans with the radiopharma-ceutical 68Ga-PSMA-HBED-CC (68Ga-PSMA-11) to diagnose prostate cancer clinical relapse.

Methods:

Eighty patients with a mean age of 68.26 years and an average prostatic-specific antigen blood level of 7.49 ng/ml (lower concentration = 0.17 ng/ml) received 68Ga-PSMA-11 intrave-nously, and full-body images of PET-CT scan were obtained. Of the total of patients admitted to the imaging service, 87.5% were examined for disease’s biochemical recurrence and clinical re-lapse, and 70.0% had a previous radical prostatectomy (RP).

Results:

Of the patients without RP, 95.8% were detected with intra-glandular disease. The 68Ga-PSMA-11 PET/CT imaging results revealed small lesions, even in patients with low blood levels of prostatic-specific antigen, mainly in metastatic cancer cases in lymph nodes and bones.

Conclusion:

The 68Ga-PSMA-11 PET/CT imaging was essential in detecting prostate cancer, with significantly high sensitivity in detecting recurrent cases. Due to its inherent reliability and sensi-tivity, PET/CT scanning with 68Ga-PSMA-11 received an increasing number of medical requests throughout the present follow-up study, confirming the augmented demand for this clinical imaging procedure in the regional medical community.
Role of Natural Plant Products Against Hemagglutinin-esterase (HE) of
Human Coronavirus
Authors: Siddique Yasir Hasan , I. Mantasha , Shahid Mohd. , Naz Falaq
Published: February 2022

Background:

COVID-19 has spread worldwide and become a great cause of economic and social loss. Due to the non-availability of effective medicine/drug, its control has become a dif-ficult task.

Objective:

In the present study, the effect of some selected natural plant products was studied on the Hemagglutinin-esterase of the human coronavirus by performing molecular docking.

Methods:

Molecular docking study for some selected natural plant products against Hemagglutinin-esterase (HE) of human coronavirus was performed using the HEX 8.0.0 software.

Results:

The free binding energy ranged from -298.14 to -161, with that of curcumin being the highest.

Conclusions:

The results suggest that the natural plant products could act as possible anti-viral agents and may be used as natural therapeutic agents.
Kontribusi Usahatani Bawang Merah terhadap Pendapatan Rumah Tangga Petani di Desa Kandangrejo Kecamatan Klambu, Kabupaten Grobogan
Authors:   Program Studi Agribisnis, Departemen Pertanian, Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Oktafiani Vika
Published: February 2022

Penelitian ini bertujuan untuk menganalisis kontribusi usahatani bawang merah terhadap pendapatan rumah tangga tani dan menganalisis pengaruh faktor-faktor harga bibit, harga pupuk urea, harga pupuk Phonska, harga pupuk ZA, harga pupuk SP-36, harga pupuk KCl, harga pestisida serta upah tenaga kerja terhadap pendapatan usahatani bawang merah. Penelitian dilasanakan pada bulan Maret dan Juli 2020 di Desa Kandangrejo Kecamatan Klambu, Kabupaten Grobogan. Metode penelitian yang digunakan adalah survei dengan mengambil sampel 82 petani bawang merah dari 445 jumlah populasi. Metode analisis data menggunakan uji one sample t-test untuk menguji kontribusi usahatani bawang merah dan uji regresi linear berganda yang ditransformasikan ke persamaan fungsi keuntungan Cobb-Douglas Unit Output Price (UOP) untuk menguji faktor-faktor yang mempengaruhi pendapatan usahatani. Hasil penelitian menunjukkan bahwa rata-rata pendapatan usahatani bawang merah sebesar Rp 59.646.928,- per 0,52 ha per musim tanam. Kontribusi usahatani bawang merah 60,33% dan termasuk kontribusi tinggi (> 50%). Faktor-faktor harga bibit, harga pupuk urea, harga pupuk Phonska, harga pupuk ZA, harga pupuk SP-36, harga pupuk KCl, harga pestisida dan upah tenaga kerja secara serempak berpengaruh signifikan terhadap pendapatan usahatani bawang merah. Secara parsial variabel harga bibit, harga pupuk urea, harga pupuk Phonska, harga pupuk ZA dan upah tenaga kerja berpengaruh signfikan terhadap pendapatan usahatani bawang merah, sedangkan variabel harga pupuk SP-36, harga pupuk KCl dan harga pestisida tidak berpengaruh.
Efektivitas Penerapan Good Dairy Farming Practice (GDFP) Pada Pendapatan Dan Tingkat Kesejahteraan Peternak Sapi Perah Rakyat Di Dataran Rendah
Authors:   Universitas Swadaya Gunung Jati, Mardhatilla Farida , Amini Zakiyah
Published: February 2022

Produksi susu sapi nasional yang rendah mengakibatkan tingginya impor susu di Indonesia. Sebanyak 3,6 juta ton atau 81% kebutuhan susu di Indonesia harus diimpor dari luar negeri (BPS,2018). Rendahnya produksi susu nasional diakibatkan oleh harga yang rendah sehingga peternak tidak berminat menggeluti usaha ini. Harga ditentukan oleh kualitas dan kuantitas susu. Kedua hal ini dapat diperoleh jika peternak menerapkan tatalaksana pengelolaan dengan benar. Tata laksana pengelolaan ternak sapi perah adalah Good Dairy Farming Sistem (GDFP). Tujuan penelitian ini untuk melihat keefektifan penerapan GDFP pada pendapatan dan kesejahteraan peternak. Penelitian ini dilakukan di Kabupaten Cirebon dengan jumlah responden 23 peternak. Metode yang digunakan adalah AHP untuk penerapan GDFP, IOFC untuk mengukur pendapatan serta koefesien korelasi pearson untuk mengukur hubungan penerapan GDFP dan pendapatan. Nilai rata – rata GDFP yang diperoleh adalah masuk dalam kategori baik (3,63). Penerapan GDFP berpengaruh pada pendapatan peternak dengan nilai korelasi pearson sebesar 0.905. Semakin tinggi nilai GDFP maka akan semakin tinggi pula pendapatan peternak tersebut.Pendapatan rata-rata yang diperoleh pada usaha ternak perah adalah Rp 1.427.759 per ekor/bulan. Peternak Kabupaten Cirebon termasuk dalam kategori sejahtera, karena rata – rata pengeluaran perkapita/bulan peternak adalah Rp 691.252 atau melebihi Rp 381.372.
Prevention of Radicalization for Muslims: Concept, Practice, Prospects
Authors:   Mogilev Institute of the Ministry of Internal Affairs of the Republic of Belarus, Ignatovich Anton
Published: February 2022

The article examines the concept, practice and prospects for the prevention of radicaliza-tion of Muslims. The purpose of this work is to highlight the general features of the prevention of radicalization of Muslims in the first quarter of the 21st century. Studying the practice of pre-venting radicalization among Muslims makes it possible to trace the development of such measures, to identify the areas of common interest at the global and national levels in the fight against modern extremism and to forecast new developments thereof. According to the author, the prevention of radicalization of Muslims is a set of measures aimed at preserving the non-radicalized state of those who are likely to face a radical Islamist ideology and become radical-ized as a result. These are representatives of local communities, young people and prisoners. The prevention of radicalization is primarily associated with information work done by joint ef-forts of government agencies, civil society activists and religious organizations. In the countries of the East, in contrast to the West, state bodies and religious structures are more active in the implementation of preventive measures. The author concludes that the effectiveness of preven-tive measures depends on correctly selected tools to counter the spread of radical ideology for each narrow group in a particular country.
Islam in the North Caucasus: Re-Islamization, Mosaicization, and the Problem of “Tradi-tionality”
Authors:   MGIMO University, Yarlykapov Akhmet , Adiev Aslanbek
Published: February 2022

This article is a result of many years of research into the contemporary diversity of cur-rents and forms of Islam in the North Caucasus, which tends to increase further. The work is based on ethnographic field research conducted regularly since the late 1990s in Adygea, Karachay-Cherkessia, Kabardino-Balkaria, Ingushetia, Stavropol Territory, and Dagestan. We also used the results of focus groups conducted with students and working youth in Dagestan, Kara-chay-Cherkessia, and Moscow. The authors conclude that there has been a reIslamization in the North Caucasus, rather than a revival of “traditional” forms of Islam in the North Caucasian regional communities, which explains the spread of new (“non-traditional”) forms of Islam in the North Caucasus. New forms of Islam in these regions of Russia are emerging as a result of globalization processes that are gradually changing the Islamic field in the North Caucasus. The competition between different forms of Islam observed here is connected with the geopolitical processes in the Middle East and does not fit into the simplistic dichotomy of “traditional” and “non-traditional” Islam for the regions of the North Caucasus. In this context, it is important for the state to find the right forms of interaction with Islamic communities and avoid the marginali-zation of certain confessional groups.
Promjena areala obične bukve (Fagus sylvatica L.) od zadnje interglacijacije (120.000 – 140.000 godina pr. n. e.) do druge polovice 21. stoljeća
Authors: Vukelić Joso , Pilaš Ivan , Baričević Dario , Medak Jasnica , Šapić Irena
Published: February 2022

/ Joso Vukelić, Ivan Pilaš, Dario Baričević, Jasnica Medak, Irena Šapić
Automatically Explaining Machine Learning Predictions on Severe Chronic Obstructive Pulmonary Disease Exacerbations: Retrospective Cohort Study (Preprint)
Authors: Zeng Siyang , Arjomandi Mehrdad , Luo Gang
Published: February 2022

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is a major cause of death and places a heavy burden on health care. To optimize the allocation of precious preventive care management resources and improve the outcomes for high-risk patients with COPD, we recently built the most accurate model to date to predict severe COPD exacerbations, which need inpatient stays or emergency department visits, in the following 12 months. Our model is a machine learning model. As is the case with most machine learning models, our model does not explain its predictions, forming a barrier for clinical use. Previously, we designed a method to automatically provide rule-type explanations for machine learning predictions and suggest tailored interventions with no loss of model performance. This method has been tested before for asthma outcome prediction but not for COPD outcome prediction.

OBJECTIVE

This study aims to assess the generalizability of our automatic explanation method for predicting severe COPD exacerbations.

METHODS

The patient cohort included all patients with COPD who visited the University of Washington Medicine facilities between 2011 and 2019. In a secondary analysis of 43,576 data instances, we used our formerly developed automatic explanation method to automatically explain our model’s predictions and suggest tailored interventions.

RESULTS

Our method explained the predictions for 97.1% (100/103) of the patients with COPD whom our model correctly predicted to have severe COPD exacerbations in the following 12 months and the predictions for 73.6% (134/182) of the patients with COPD who had ≥1 severe COPD exacerbation in the following 12 months.

CONCLUSIONS

Our automatic explanation method worked well for predicting severe COPD exacerbations. After further improving our method, we hope to use it to facilitate future clinical use of our model.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/13783
“Is this Herpes or Syphilis?”: Latent Dirichlet Allocation Analysis of Sexually Transmitted Disease-Related Reddit Posts During the COVID-19 Pandemic (Preprint)
Authors: Johnson Amy , Bhaumik Runa , Nandi Debarghya , Roy Abhishikta , Mehta Supriya D
Published: February 2022

BACKGROUND

Sexually Transmitted Diseases (STDs) are common and costly, impacting approximately one in five people annually. Reddit, the sixth most used internet site in the world, is a user-generated social media discussion platform that may be useful in monitoring discussion about STD symptoms and exposure.

OBJECTIVE

This study sought to define and identify patterns and insights into STD related discussions on Reddit over the course of the COVID-19 pandemic.

METHODS

We extracted posts from Reddit from March 2019 through July 2021. We used a machine learning text mining method, Latent Dirichlet Allocation (LDA), to conduct a text analysis to identify the most common topics discussed in the Reddit posts. We then used word clouds, qualitative topic labelling, and spline regression to characterize the content and distribution of topics observed.

RESULTS

Our extraction resulted in 24,311 total posts. LDA Coding showed that with 8 topics for each time period we achieved high coherence values (pre-COVID=0.41, pre-vaccine=0.42; post-vaccine=0.44). While most topic categories remained the same over time, the relative proportion of topics changed and new topics emerged. Spline regression revealed some key terms had variability in the percentage of posts that coincided with COVID-19 pre- and post- periods, while others were uniform across the study periods.

CONCLUSIONS

Our study’s use of Reddit is a novel way to gain insights into STD symptoms experienced, potential exposures, testing decisions, common questions, and behavior patterns (e.g., during lock down periods). For example, reduction in STD screening may result in observed negative health outcomes due to missed cases, which also impacts onward transmission. As Reddit use is anonymous, users may discuss sensitive topics with greater detail, and more freely than in clinical encounters. Data from anonymous Reddit posts may be leveraged to enhance understanding of the distribution of disease and need for targeted outreach/screening programs. This study demonstrates Reddit has feasibility and utility to enhance understanding of sexual behaviors, STD experiences, and needed health engagement with the public.
Administration of Early Childhood Care Education Centers in Post COVID-19 Pandemic: Implications for New Policies on Emerging Health Issues (Preprint)
Authors: Nweke 5th Prince
Published: February 2022

BACKGROUND

The study was to investigate the impact of covid-19 pandemic lockdown and practices towards stemming the tide its major outbreak in early childhood care education centers (ECCE) in Nigeria.

OBJECTIVE

The objective of the study is to find out quality assurance measures adopted to mitigate impact of covid-19 pandemic in administration of ECCE centers in Nsukka Local Government Area of Enugu State, Nigeria.

METHODS

The study adopted a descriptive survey design. The population of the study was made up of 823 personnel consisting of 125 ECCE center administrators and 698 caregivers. The sample for the study was 329 respondents made up of 50 administrators and 279 caregivers. Proportionate stratified random sampling technique was used to select 40% of each category of populations from 50 ECCE centers. Three research questions were posed for the study using mean scores and standard deviation while one hypothesis was formulated to guide the study and tested using t-test statistics at 0.05 level of significance. Instrument for data collection was a structured questionnaire titled: Covid-19pandemic Impact in Administration of Early Childhood Care and Education Centers Questionnaire (COPIAECCEQ). The instrument was validated by three experts. Cronbach Alpha was used to test the internal consistency of the instrument which established a reliability coefficient with an overall reliability of 0.82.

RESULTS

The findings of the study revealed that there were not enough measures put in place by ECCE centers administrator to check the spread of covid-19.

CONCLUSIONS

Government intervention support scheme to education during a global health crisis will help to mitigate the negative impact on the learners and learning experience.
Sensor Data Integration: How can a situational awareness data integration approach in health data platforms lead to better-informed outcomes in healthcare (Preprint)
Authors: Van De Keere Isabel , Vandebelt Katherine , Angelopoulos Christian , Blocker Aaron , Carvajal Rodrigo , Dowling Ariel V. , Drummond David , Fanarjian Manuel , Iyer Shruti , Lagally Michael , McManus Kimberly F. , Oakley-Girvan Ingrid , Patel Krupal B. , Silberman Jordan , Yunis Reem , Goldsack Jennifer , Clay Ieuan
Published: February 2022

UNSTRUCTURED

Data integration, the processes by which data is aggregated, interpreted, combined, and made available for use, has been key to the development and growth of many technological solutions. In health care, we are experiencing a revolution in the use of sensors to collect data on patient behaviors and experiences. Yet, the potential of these data to transform health outcomes has been limited to date. Deficits in standards, use of different terminology, different metric systems, data rights, permissioning, privacy, and security have been well documented as challenges to digital innovation. However, the cultural adoption of sensor data integration as a priority for large-scale deployment and impact on patient lives has yet to be examined.
In this paper, we take an in-depth look at case studies of sensor data integration into health data platforms for clinical research and patient care to advance key considerations in order to achieve the promise of digital health to improve clinical research and patient care at scale. These considerations are designed to support optimized, holistic (i.e. anchored in value for end consumers and patients) decision making and enable more effective sensor data integration by increasing accessibility, reliability, and trustworthiness to multiple users. We share intermediate insights from our multi-stakeholder project focused on putting forward an early framework and toolkit for sensor data integration and enable more situational awareness, thereby ensuring the future success of healthcare data integration as a whole.
Review: Analisis Fitur Deteksi Aritmia dan Metode Deep Learning untuk Wearable Devices
Authors: Ratna Lestari Budiani Buana  , Imroatul Hudati
Published: February 2022

Aritmia merupakan salah satu gangguan jantung, yang mungkin tidak berbahaya dalam waktu dekat, tetapi dapat mengakibatkan abnormalitas jangka panjang. Meskipun tidak berbahaya, harus ada penanganan medis yang segera dilakukan dan perubahan lifestyle menjadi lebih baik. Deteksi aritmia umumnya dilakukan dengan elektrokardiograf (EKG) long recording menggunakan monitor Holter dan kemudian dianalisis ritmenya. Perekaman dengan Holter yang memerlukan waktu beberapa hari dapat mengganggu fisiologis pasien. Banyak penelitian telah dilakukan untuk membangun algoritme pendeteksian aritmia, dengan beragam sumber data, fitur, dan juga metode pendeteksian. Namun, permasalahan yang umum dihadapi oleh banyak peneliti adalah masalah waktu komputasi dan kompleksnya fitur yang dideteksi. Studi ini dilakukan untuk melakukan review terhadap penelitian yang sudah dilakukan terkait dengan penggunaan data, fitur, dan juga metode deep learning yang dapat menyelesaikan masalah waktu komputasi dan memungkinkan implementasi pada wearable devices. Studi diawali dengan pencarian literatur terkait, kemudian melihat basis data yang digunakan untuk membangun model deteksi. Selanjutnya, review dilanjutkan dengan menelaah fitur EKG yang digunakan dan juga metode deep learning yang diimplementasikan. Dari hasil review yang dilakukan, data yang umum digunakan adalah data yang bersumber dari dataset MIT-BIH, meskipun penggunaan data dinilai masih perlu pre-processing yang cukup rumit. Convolutional neural network (CNN) merupakan metode yang banyak digunakan, walaupun waktu komputasi menjadi salah satu pertimbangan. Analisis yang paling tepat untuk pendeteksian gangguan ritme dan memiliki waktu komputasi yang rendah adalah fitur interval sinyal EKG dengan analisis di domain waktu. Fitur tersebut nantinya akan digunakan sebagai masukan deep learning. Dengan begitu, waktu komputasi akan dapat banyak dikurangi, terutama ketika diterapkan pada wearable devices.
Molecular Identification, Characterization and Improvement of A Chitinase Producing Bacillus strain Showing Significant Control against Some Dermatophytic Fungi
Authors: Sheikh Huda Mohammed Ahmed , Hamshary Ola I.M. , Khattab Abd El-Nasser Abd El-Hafez
Published: February 2022

Bacillus bacteria are advantageous antagonistic organisms that can be used as bio-control agents. This study is aimed at screening the antagonistic activity of different strains of isolated Bacillus bacteria and molecular identification of the superior chitinase producer strain against dermatophytes fungi. Soil samples were collected from different places of Kotoor city, Gharbia Governorate, Egypt and Al Madina Al Munawwarah, Kingdom of Saudi Arabia. A collection of Bacillus isolated from soil was tested in vitro against the dermatophytes: Microsporum sp. and Trichophyton sp. The bacterial strains Kh-B1 and Kh-B2 showed the highest antagonistic activity against dermatophytes pathogenic fungi. The highest amount of chitinase productivity (13.6 units/ml) was obtained from the original Bacillus strain (Kh-B1) at 3 days of incubation. BLAST analysis of the amplified 16S ribosomal RNA gene sequence identified the Bacillus strain (Kh-B1) as Paenibacillus macerans. Upon the mutation induction by UV light, the highest chitinase-producing mutant was Kh-UVB-4 as it showed 305.88 percent production higher than the wild-type strain. While, upon the mutation induction by EMS, the highest amount of chitinase produced was 54.8 units/ml by mutant Kh-ESB-20, and it has produced 402.94% more than the original untreated strain. The application of RAPD-PCR protocol using three 15-mer random primers was used to determine the genetic effects of mutagenic treatments on the wild type strain (Kh-B1) as well as to demonstrate the genetic variability between the five most chitinase producing mutants and the wild type (Paenibacillus macerans).
N-acyl Homoserine Lactone Mediated Quorum Sensing Exhibiting Plant Growth-promoting and Abiotic Stress Tolerant Bacteria Demonstrates Drought Stress Amelioration
Authors: Singh Arpita , Chauhan Puneet Singh
Published: February 2022

Multiple plant growth-promoting attributes with N-acyl homoserine lactone (AHL)-mediated quorum sensing exhibiting bacterial strains can help plants to withstand varying abiotic and biotic stress conditions for improving the plant health and productivity. In total, 306 bacterial isolates were isolated from diverse locations and sites. In our exploration, bacterial isolates were screened based on AHL production, plant growth-promoting attributes, abiotic stress tolerance, and antagonistic activity against phytopathogenic fungi. Among the screened 306 isolates, 4 (11VPKHP4, 7VP51.8, P51.10, NBRI N7) were selected based on their efficiency in AHL production, biofilm formation, enduring different abiotic stress conditions, exhibiting plant growth-promoting attributes, and antagonistic activity. Based on 16S rRNA gene sequencing analyses of the selected 4 isolates belong to Pseudomonas genera. Selected isolates 11VPKHP4, 7VP51.8, P51.10, and NBRI N7 were also proficient in biosurfactant production, emulsification, suggesting that all isolates fabricate emulsifiers. The plant growth promotion potential of selected 4 bacterial isolates showed significant growth enhancement in all the vegetative parameters of Zea mays under control as well as drought stress condition. Biochemical parameters and defense enzymes under drought stress conditions were also modulated in the PGPR treated plants as compared to their uninoculated respective controls. With quorum sensing, multiple PGPR attributes, stress tolerance, biofilm formation, and EPS production the selected isolates have the potential to facilitate enhanced plant growth, rhizosphere colonization, maintenance of soil moisture content under normal and diverse stresses.
Nipah Virus Mystery: Insight into Transmission and Mechanism of Disease Progression
Authors: Hassan Dania , Ravindran Roshni , Hossain Ashfaque
Published: February 2022

Nipah virus (NiV) belongs to the biosafety level four (BSL-4) group of human pathogens of zoonotic origin. It is an emerging pathogen capable of causing a variety of clinical presentations, including encephalitis and severe acute respiratory illness, which can be fatal. Interestingly, it can also cause asymptomatic infections, which can relapse after a long period of time ranging from months to years following initial infection. Zoonotic transmission involves bats or pigs. In addition, transmission via contaminated food and occasional human to human direct transmission may also occur. It can have diverse epidemiological features and can have a very high case fatality ratio. Although a variety of immunological and molecular assays have been developed and epidemiological monitoring procedures for this disease have been introduced, there are no drugs available for this virus. Vaccines are at different stages of development. In this mini-review, we present the latest information on the Nipah virus; primarily focusing on emergence, transmission, pathogenic mechanisms and possible prophylactic and treatment options.