bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Manufacturing Performance Evaluation at the Enterprise Level: Index- and Value-Based Methods
Authors: Huang A. , Badurdeen F.
Published: August 2017

Sustainability is a key principle that has been intensely discussed over the past two decades. In this context, sustainable manufacturing, which involves the use of sustainable processes and systems to produce more sustainable products, is becoming increasingly important for corporate success. Companies that compete globally are increasingly required to commit to and report on the overall sustainability performance of operational initiatives. While a variety of performance evaluation methods have been presented in literature, for sustainable manufacturing performance evaluation at the enterprise level, none comprehensively cover the three pillars of sustainability, embrace the total life-cycle perspective, or consider the 6Rs of reduce, reuse, recover, redesign, and remanufacture simultaneously. In this paper, two alternate index-based and value-based methods were proposed to evaluate sustainable manufacturing performance at the enterprise level to comprehensively consider all the previously mentioned aspects. A sustainable manufacturing performance evaluation framework was used to identify enterprise sustainability metrics which are then converted to an index with a five-level hierarchical process. The same metrics were then used to propose a value-based measure for enterprise level sustainable manufacturing performance evaluation. Application of these two methods were illustrated for a representative enterprise producing consumer electronics to compare and analyze performance over a four year period. The two methods provide comparable results, indicating either can be used to evaluate sustainable manufacturing performance at the enterprise level in manufacturing organizations. The assessment methods also provide insights for future studies that can further explore sustainability metrics and evaluation methods for other levels across the supply chain.
Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness
Authors: Minert Anne , Yatziv Shai-Lee , Devor Marshall
Published: August 2017

The transition from wakefulness to general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and antinociception). An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spinal cord mediated by dedicated axonal pathways. Previously, we documented induction of an anesthesia-like state in rats by microinjection of small amounts of GABAA-receptor agonists into an upper brainstem region named the mesopontine tegmental anesthesia area (MPTA). Correspondingly, lesioning this area rendered animals resistant to systemically delivered anesthetics. Here, using rats of both sexes, we applied a modified microinjection method that permitted localization of the anesthetic-sensitive neurons with much improved spatial resolution. Microinjected at the MPTA hotspot identified, exposure of 1900 or fewer neurons to muscimol was sufficient to sustain whole-body general anesthesia; microinjection as little as 0.5 mm off-target did not. The GABAergic anesthetics pentobarbital and propofol were also effective. The GABA-sensitive cell cluster is centered on a tegmental (reticular) field traversed by fibers of the superior cerebellar peduncle. It has no specific nuclear designation and has not previously been implicated in brain-state transitions.

SIGNIFICANCE STATEMENTGeneral anesthesia permits pain-free surgery. Furthermore, because anesthetic agents have the unique ability to reversibly switch the brain from wakefulness to a state of unconsciousness, knowing how and where they work is a potential route to unraveling the neural mechanisms that underlie awareness itself. Using a novel method, we have located a small, and apparently one of a kind, cluster of neurons in the mesopontine tegmentum that are capable of effecting brain-state switching when exposed to GABAA-receptor agonists. This action appears to be mediated by a network of dedicated axonal pathways that project directly and/or indirectly to nearby arousal nuclei of the brainstem and to more distant targets in the forebrain and spinal cord.
Plasticity Beyond V1: Reinforcement of Motion Perception upon Binocular Central Retinal Lesions in Adulthood
Authors: Burnat Kalina , Hu Tjing-Tjing , Kossut Małgorzata , Eysel Ulf T. , Arckens Lutgarde
Published: August 2017

Induction of a central retinal lesion in both eyes of adult mammals is a model for macular degeneration and leads to retinotopic map reorganization in the primary visual cortex (V1). Here we characterized the spatiotemporal dynamics of molecular activity levels in the central and peripheral representation of five higher-order visual areas, V2/18, V3/19, V4/21a,V5/PMLS, area 7, and V1/17, in adult cats with central 10° retinal lesions (both sexes), by means of real-time PCR for the neuronal activity reporter genezif268.The lesions elicited a similar, permanent reduction in activity in the center of the lesion projection zone of area V1/17, V2/18, V3/19, and V4/21a, but not in the motion-driven V5/PMLS, which instead displayed an increase in molecular activity at 3 months postlesion, independent of visual field coordinates. Also area 7 only displayed decreased activity in its LPZ in the first weeks postlesion and increased activities in its periphery from 1 month onward. Therefore we examined the impact of central vision loss on motion perception using random dot kinematograms to test the capacity for form from motion detection based on direction and velocity cues. We revealed that the central retinal lesions either do not impair motion detection or even result in better performance, specifically when motion discrimination was based on velocity discrimination. In conclusion, we propose that central retinal damage leads to enhanced peripheral vision by sensitizing the visual system for motion processing relying on feedback from V5/PMLS and area 7.

SIGNIFICANCE STATEMENTCentral retinal lesions, a model for macular degeneration, result in functional reorganization of the primary visual cortex. Examining the level of cortical reactivation with the molecular activity markerzif268revealed reorganization in visual areas outside V1. Retinotopic lesion projection zones typically display an initial depression inzif268expression, followed by partial recovery with postlesion time. Only the motion-sensitive area V5/PMLS shows no decrease, and even a significant activity increase at 3 months post-retinal lesion. Behavioral tests of motion perception found no impairment and even better sensitivity to higher random dot stimulus velocities. We demonstrate that the loss of central vision induces functional mobilization of motion-sensitive visual cortex, resulting in enhanced perception of moving stimuli.
Role of Somatostatin-Positive Cortical Interneurons in the Generation of Sleep Slow Waves
Authors: Funk Chadd M. , Peelman Kayla , Bellesi Michele , Marshall William , Cirelli Chiara , Tononi Giulio
Published: August 2017

During non-rapid eye-movement (NREM) sleep, cortical and thalamic neurons oscillate every second or so between ON periods, characterized by membrane depolarization and wake-like tonic firing, and OFF periods, characterized by membrane hyperpolarization and neuronal silence. Cortical slow waves, the hallmark of NREM sleep, reflect near-synchronous OFF periods in cortical neurons. However, the mechanisms triggering such OFF periods are unclear, as there is little evidence for somatic inhibition. We studied cortical inhibitory interneurons that express somatostatin (SOM), because ∼70% of them are Martinotti cells that target diffusely layer I and can block excitatory transmission presynaptically, at glutamatergic terminals, and postsynaptically, at apical dendrites, without inhibiting the soma. In freely moving male mice, we show that SOM+ cells can fire immediately before slow waves and their optogenetic stimulation during ON periods of NREM sleep triggers long OFF periods. Next, we show that chemogenetic activation of SOM+ cells increases slow-wave activity (SWA), slope of individual slow waves, and NREM sleep duration; whereas their chemogenetic inhibition decreases SWA and slow-wave incidence without changing time spent in NREM sleep. By contrast, activation of parvalbumin+ (PV+) cells, the most numerous population of cortical inhibitory neurons, greatly decreases SWA and cortical firing, triggers short OFF periods in NREM sleep, and increases NREM sleep duration. Thus SOM+ cells, but not PV+ cells, are involved in the generation of sleep slow waves. Whether Martinotti cells are solely responsible for this effect, or are complemented by other classes of inhibitory neurons, remains to be investigated.

SIGNIFICANCE STATEMENTCortical slow waves are a defining feature of non-rapid eye-movement (NREM) sleep and are thought to be important for many of its restorative benefits. Yet, the mechanism by which cortical neurons abruptly and synchronously cease firing, the neuronal basis of the slow wave, remains unknown. Using chemogenetic and optogenetic approaches, we provide the first evidence that links a specific class of inhibitory interneurons—somatostatin-positive cells—to the generation of slow waves during NREM sleep in freely moving mice.
Effector-Invariant Movement Encoding in the Human Motor System
Authors: Haar Shlomi , Dinstein Ilan , Shelef Ilan , Donchin Opher
Published: August 2017

Ipsilateral motor areas of cerebral cortex are active during arm movements and even reliably predict movement direction. Is coding similar during ipsilateral and contralateral movements? If so, is it in extrinsic (world-centered) or intrinsic (joint-configuration) coordinates? We addressed these questions by examining the similarity of multivoxel fMRI patterns in visuomotor cortical regions during unilateral reaching movements with both arms. The results of three complementary analyses revealed that fMRI response patterns were similar across right and left arm movements to identical targets (extrinsic coordinates) in visual cortices, and across movements with equivalent joint-angles (intrinsic coordinates) in motor cortices. We interpret this as evidence for the existence of distributed neural populations in multiple motor system areas that encode ipsilateral and contralateral movements in a similar manner: according to their intrinsic/joint coordinates.

SIGNIFICANCE STATEMENTCortical motor control exhibits clear lateralization: each hemisphere controls the motor output of the contralateral body. Nevertheless, neural populations in ipsilateral areas across the visuomotor hierarchy are active during unilateral movements. We show that fMRI response patterns in the motor cortices are similar for both arms if the movement direction is mirror-reversed across the midline. This suggests that in both ipsilateral and contralateral motor cortices, neural populations have effector-invariant coding of movements in intrinsic coordinates. This not only affects our understanding of motor control, it may serve in the development of brain machine interfaces that also use ipsilateral neural activity.
Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats
Authors: Serrano-Nascimento Caroline , Salgueiro Rafael Barrera , Vitzel Kaio Fernando , Pantaleão Thiago , Corrêa da Costa Vânia Maria , Nunes Maria Tereza
Published: August 2017

Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Therefore, this study aimed to investigate the impact of IE exposure during pregnancy and lactation periods on maternal hypothalamus–pituitary–thyroid axis. IE-exposed dams presented reduced serum TH concentration and increased serum thyrotropin (TSH) levels. Moreover, maternal IE exposure increased the hypothalamic expression of Trh and the pituitary expression of Trhr, Dio2, Tsha and Tshb mRNA, while reduced the Gh mRNA content. Additionally, IE-exposed dams presented thyroid morphological alterations, increased thyroid oxidative stress and decreased expression of thyroid genes/proteins involved in TH synthesis, secretion and metabolism. Furthermore, Dio1 mRNA expression and D1 activity were reduced in the liver and the kidney of IE-treated animals. Finally, the mRNA expression of Slc5a5 and Slc26a4 were reduced in the mammary gland of IE-exposed rats. The latter results are in accordance with the reduction of prolactin expression and serum levels in IE-treated dams. In summary, our study indicates that the exposure to IE during pregnancy and lactation induces primary hypothyroidism in rat dams and impairs iodide transfer to the milk.
Effects of nicotine on homeostatic and hedonic components of food intake
Authors: Stojakovic Andrea , Espinosa Enma P , Farhad Osman T , Lutfy Kabirullah
Published: August 2017

Chronic tobacco use leads to nicotine addiction that is characterized by exaggerated urges to use the drug despite the accompanying negative health and socioeconomic burdens. Interestingly, nicotine users are found to be leaner than the general population. Review of the existing literature revealed that nicotine affects energy homeostasis and food consumption via altering the activity of neurons containing orexigenic and anorexigenic peptides in the brain. Hypothalamus is one of the critical brain areas that regulates energy balance via the action of these neuropeptides. The equilibrium between these two groups of peptides can be shifted by nicotine leading to decreased food intake and weight loss. The aim of this article is to review the existing literature on the effect of nicotine on food intake and energy homeostasis and report on the changes that nicotine brings about in the level of these peptides and their receptors that may explain changes in food intake and body weight induced by nicotine. Furthermore, we review the effect of nicotine on the hedonic aspect of food intake. Finally, we discuss the involvement of different subtypes of nicotinic acetylcholine receptors in the regulatory action of nicotine on food intake and energy homeostasis.
Single-cell gene expression of the bovine blastocyst
Authors: Negrón-Pérez Verónica M , Zhang Yanping , Hansen Peter J
Published: August 2017

The first two differentiation events in the embryo result in three cell types – epiblast, trophectoderm (TE) and hypoblast. The purpose here was to identify molecular markers for each cell type in the bovine and evaluate the differences in gene expression among individual cells of each lineage. The cDNA from 67 individual cells of dissociated blastocysts was used to determine transcript abundance for 93 genes implicated as cell lineage markers in other species or potentially involved in developmental processes. Clustering analysis indicated that the cells belonged to two major populations (clades A and B) with two subpopulations of clade A and four of clade B. Use of lineage-specific markers from other species indicated that the two subpopulations of clade A represented epiblast and hypoblast respectively while the four subpopulations of clade B were TE. Among the genes upregulated in epiblast were AJAP1, DNMT3A, FGF4, H2AFZ, KDM2B, NANOG, POU5F1, SAV1 and SLIT2. Genes overexpressed in hypoblast included ALPL, FGFR2, FN1, GATA6, GJA1, HDAC1, MBNL3, PDGFRA and SOX17, while genes overexpressed in all four TE populations were ACTA2, CDX2, CYP11A1, GATA2, GATA3, IFNT, KRT8, RAC1 and SFN. The subpopulations of TE varied among each other for multiple genes including the prototypical TE marker IFNT. New markers for each cell type in the bovine blastocyst were identified. Results also indicate heterogeneity in gene expression among TE cells. Further studies are needed to confirm whether subpopulations of TE cells represent different stages in the development of a committed TE phenotype.
Accumulation of Deleterious Mutations During Bacterial Range Expansions
Authors: Bosshard Lars , Dupanloup Isabelle , Tenaillon Olivier , Bruggmann Rémy , Ackermann Martin , Peischl Stephan , Excoffier Laurent
Published: August 2017

Recent theoretical work suggested that deleterious mutations could accumulate during the range expansion of a species, negatively affecting its fitness.

Recent theory predicts that the fitness of pioneer populations can decline when species expand their range, due to high rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants. To test these predictions, we studied the fate of mutator bacteria expanding their range for 1650 generations on agar plates. In agreement with theory, we find that growth abilities of strains with a high mutation rate (HMR lines) decreased significantly over time, unlike strains with a lower mutation rate (LMR lines) that present three to four times fewer mutations. Estimation of the distribution of fitness effect under a spatially explicit model reveals a mean negative effect for new mutations (−0.38%), but it suggests that both advantageous and deleterious mutations have accumulated during the experiment. Furthermore, the fitness of HMR lines measured in different environments has decreased relative to the ancestor strain, whereas that of LMR lines remained unchanged. Contrastingly, strains with a HMR evolving in a well-mixed environment accumulated less mutations than agar-evolved strains and showed an increased fitness relative to the ancestor. Our results suggest that spatially expanding species are affected by deleterious mutations, leading to a drastic impairment of their evolutionary potential.
Politinio pokyčio konceptualizacijos Alaino Badiou ir Jacques’o Rancière’o teorijose
Authors: Jonutis Karolis
Published: August 2017

This article discusses the conceptualizations of political transformation, proposed in the political theories of Alain Badiou and Jacques Rancière. These authors criticize the disappearance of ideological differences in modern liberal democratic states. As their subject, they choose the marginal parts of society, which can make a rupture in an existing status quo by acting collectively and rebelliously. Both authors propose theories of praxis, in which thoughts have an influence on the material world and, on the opposite, the material world having influence on theory. This article examines the transformational logic of these political concepts and tries to reveal their main limitations.
Intergenerational Value Differences in Contemporary Lithuanian Society
Authors: Žiliukaitė Rūta
Published: August 2017

The article uses European Value Survey data to analyze intergenerational differences in Lithuanian society in the domains of religion, morality, family, work and sociopolitical attitudes and the development of these differences during the twenty years of independence. Results of the analysis show atrend of an intercohort value change in 1990-2008 toward increasing individual secularization, moderation of conservative attitudes in the domains of family and individual sexual morality as well as leniency toward breaches of public morality. The development of work-related attitudes does not show any intercohort differences in value orientations. These trajectories of development can be explained by a variety of interrelated macro-level factors: Lithuanian cultural and historical heritage, structural changes that took place in the transition of society, characteristics of the existing institutional context, modernization of society, media- and globalization-induced spread of Western culture.
Understanding Structure of Poverty Dimensions in East Java: Bicluster Approach
Authors: Yuniarto Budi , Kurniawan Robert
Published: August 2017

Poverty is still become a main problem for Indonesia, where recently, the view point of poverty is not just from income or consumption, but it’s defined multidimensionally. The understanding of the structure of multidimensional poverty is essential to government to develop policies for poverty reduction. This paper aims to describe the structure of poverty in East Java by using variables forming the dimensions of poverty and to investigate any clustering patterns in the region of East Java with considering the poverty variables using biclustering method. Biclustering is an unsupervised technique in data mining where we are grouping scalars from the two-dimensional matrix. Using bicluster analysis, we found two bicluster where each bicluster has different characteristics.DOI: 10.15408/sjie.v6i2.4769
Parent Coping Support Interventions During Acute Pediatric Hospitalizations: A Meta-Analysis
Authors: Doupnik Stephanie K. , Hill Douglas , Palakshappa Deepak , Worsley Diana , Bae Hanah , Shaik Aleesha , Qiu Maylene (Kefeng) , Marsac Meghan , Feudtner Chris
Published: August 2017

CONTEXT:

Parents may experience psychological distress when a child is acutely hospitalized, which can negatively affect child outcomes. Interventions designed to support parents’ coping have the potential to mitigate this distress.

OBJECTIVE:

To describe interventions designed to provide coping support to parents of hospitalized children and conduct a meta-analysis of coping support intervention outcomes (parent anxiety, depression, and stress).

DATA SOURCES:

We searched Pubmed, Embase, PsycINFO, Psychiatry Online, and Cumulative Index to Nursing and Allied Health Literature from 1985 to 2016 for English-language articles including the concepts “pediatric,” “hospitalization,” “parents,” and “coping support intervention.”

STUDY SELECTION:

Two authors reviewed titles and abstracts to identify studies meeting inclusion criteria and reviewed full text if a determination was not possible using the title and abstract. References of studies meeting inclusion criteria were reviewed to identify additional articles for inclusion.

DATA EXTRACTION:

Two authors abstracted data and assessed risk of bias by using a structured instrument.

RESULTS:

Initial searches yielded 3450 abstracts for possible inclusion. Thirty-two studies met criteria for inclusion in the systematic review and 12 studies met criteria for inclusion in the meta-analysis. The most commonly measured outcomes were parent depression, anxiety, and stress symptoms. In meta-analysis, combined intervention effects significantly reduced parent anxiety and stress but not depression. Heterogeneity among included studies was high.

LIMITATIONS:

Most included studies were conducted at single centers with small sample sizes.

CONCLUSIONS:

Coping support interventions can alleviate parents’ psychological distress during children’s hospitalization. More evidence is needed to determine if such interventions benefit children.
Violência obstétrica: revisão integrativa de pesquisas qualitativas
Authors: Barbosa Luara De Carvalho , Fabbro Márcia Regina Cangiani , Machado Geovânia Pereira dos Reis
Published: August 2017

Objetivo: Describir cómo los factores que afectan las prácticas de atención del parto interfieren en la experiencia del parto y en el nacimiento.Síntesis de contenido: Se trata de una revisión integradora de investigaciones cualitativas. A partir de las búsquedas en las bases de datos seleccionadas, se encontraron 17 051 artículos,de los cuales, según los criterios preestablecidos, se eligieron 54. De acuerdo con el análisis de los estudios elegidos, emergieron cuatro categorías, a saber: Preconcepciones contemporáneas sobre el parto normal y la cesárea, Elementos desfavorables para la vivencia satisfactoria del parto, Banalización de la violencia obstétrica y Presupuestos sobre la asistencia humanizada del parto. Los resultados revelaron que las prácticas de asistencia al parto estaban desactualizadas, eran inapropiadas, se consideraban“normales” y estaban marcadas por el autoritarismo y por la falta de respeto hacia las mujeres, lo cual caracteriza la violencia obstétrica. Por su parte, el modelo humanizado, al valorar elprotagonismo femenino, hace que la experiencia del parto sea más gratificante. Conclusión: Las prácticas de asistencia al parto en Brasil no respetan los derechos sexuales y reproductivos, lo que se refleja en los altos índices de cesáreas innecesarias y en los maltratos que las mujeres sufren en los hospitales materno-infantilesbrasileños.
Functional impairment matters in the screening and diagnosis of gaming disorder
Authors: Billieux Joël , King Daniel L. , Higuchi Susumu , Achab Sophia , Bowden-Jones Henrietta , Hao Wei , Long Jiang , Lee Hae Kook , Potenza Marc N. , Saunders John B. , Poznyak Vladimir
Published: August 2017

This commentary responds to Aarseth et al.’s (in press) criticisms that the ICD-11 Gaming Disorder proposal would result in “moral panics around the harm of video gaming” and “the treatment of abundant false-positive cases.” The ICD-11 Gaming Disorder avoids potential “overpathologizing” with its explicit reference to functional impairment caused by gaming and therefore improves upon a number of flawed previous approaches to identifying cases with suspected gaming-related harms. We contend that moral panics are more likely to occur and be exacerbated by misinformation and lack of understanding, rather than proceed from having a clear diagnostic system.
Inclusion of gaming disorder in the diagnostic classifications and promotion of public health response
Authors: Shadloo Behrang , Farnam Rabert , Amin-Esmaeili Masoumeh , Hamzehzadeh Marziyeh , Rafiemanesh Hosein , Jobehdar Maral Mardaneh , Ghani Kamyar , Charkhgard Nader , Rahimi-Movaghar Afarin
Published: August 2017

There are ongoing controversies regarding the upcoming ICD-11 concept of gaming disorder. Recently, Aarseth et al. have put this diagnostic entity into scrutiny. Although we, a group of Iranian researchers and clinicians, acknowledge some of Aarseth et al.’s concerns, believe that the inclusion of gaming disorder in the upcoming ICD-11 would facilitate necessary steps to raise public awareness, enhance development of proper diagnostic approaches and treatment interventions, and improve health and non-health policies.
Evaluation and prediction of cyclic response of Q690D steel
Authors: Wang Yan-Bo , Li Guo-Qiang , Sun Xu , Chen Suwen , Hai Le-Tian
Published: August 2017

High-strength structural steel of nominal yield strength greater than 690 MPa is difficult to produce in the hot-rolled condition without heat treatment. Quenching and tempering are thus commonly used to trade ductility for high strength. However, in seismic regions, good ductility of steel structural members is required to endure expected inelastic deformation under severe earthquake actions. This paper describes an experimental investigation on the mechanical properties and hysteretic behaviour of Q690D steel through 29 tensile coupon tests and 14 cyclic loading coupon tests subjected to four different cyclic patterns. The 16 mm and 40 mm quenched and tempered Q690D steel plates used in this study are equivalent to S690Q steel according to EN 10025-6. The test results of Q690D steel were compared with the ductility requirements of current seismic design codes. Under cyclic loading, Q690D steel showed cyclic softening. Based on analysis of the test results, a combined isotropic and kinematic hardening hysteretic model was developed to predict the cyclic behaviour of Q690D steel, with consideration of the Bauschinger effect and cyclic softening behaviour.
A Study of Food Tourism Participation Activity as it Relates to Tourism Satisfaction and Behavioral Intention: The Mediating Effect of Tourism Satisfaction
Authors:   The Tourism Sciences Society Of Korea, Kim Sung-Gon , Lee Sun-Ho , Lee Jong-Ho
Published: August 2017

This study verifies the structural causation of tourism satisfaction and behavioral intention as well as the mediating effect of tourism satisfaction on culinary tour participation activities. This was accomplished using a questionnaire distributed among 212 local residents throughout Busan from January 15th to January 30th, 2017. SPSS(V23.0) and AMOS(V21.0) programs were used to analyze the demographic characteristics and ensure the reliability of each measurement item. Confirmatory factors, and correlational analysis have been performed to measure correlations between the pairs of elicited factors analyzed in order to achieve the research purpose of the study. Structural Equation Modeling was used to test fidelity, systematic causation of the complete model, and the mediating effect of tourism satisfaction. The research results demonstrate that each sub factor of participating activities in culinary tourism has collectively the largest significant causation effect on tourism satisfaction. Furthermore, tourism satisfaction acts as a causation of behavioral intent as well. The mediating effect of tourism satisfaction is most significant in terms of tourism cuisine, and partially mediated in the culinary experience participation. However, no mediating effect was detected in the purchase of regional specialty products. These implied culinary tourism participation activities present in the results prove the influence of tourism satisfaction as a systematic causation of behavioral intent. The results also show the mediating effect of tourism satisfaction on behavioral intent through tourism cuisine. Therefore, it is recommended that regional government organizations discover renowned restaurants and traditional cuisine to actively market culinary tourism and seek administrative and financial support.
Casino Research in Korea: A Content Analysis and Implications for Future Research
Authors:   The Tourism Sciences Society Of Korea, Cho Kwang-Eik , Oh Min-Jae
Published: August 2017

This study reviewed Korean casino research published in selected two Korean top hospitality and tourism journals (Journal of Tourism Sciences and Korean Journal of Hospitality & Tourism) for the period of 1977(1993)~2016. Ninety-three full articles from the journals were selected for content analysis. This study looked at research topics, research objects, research designs such as sampling methods and data collection, methodological aspects, and financial support institution for research. Significant trends in research topics were identified and discussed to raise issues for future research. A table at the end of the study illustrated an overview of different characteristic of two Korean top journals. Readers could gain insights into past research and ideas for future research from the study. The study concluded with limitations of this study and general suggestions for future casino research in Korea.
The Impact of Fine Particular Matter Risk Perception on the Outdoor Behavior of Recreationists: An Application of the Extended Theory of Planned Behavior
Authors:   The Tourism Sciences Society Of Korea, Lee Hyun-Young , Kim Nam-Jo
Published: August 2017

This study examined the way in which risk perception of fine particular matter influences behavioral intention within the larger context of outdoor recreation. Risk perceptions of fine particular matter were classified into three sub-dimensions: social-environmental risk, economic risk, and physical risk. Then, these sub-dimensions were applied to the theory of planned behavior. 345 responses were collected from recreationists throughout the Han-river region of Seoul. The results of data analysis prove that the socio-environmental and physical risks of fine particular matter positively influence attitudes and subjective norms among recreationists. This influence is also reflected in environmental perspectives but not in perceived behavioral control. On the contrary, there were no statistically significant differences among economic risk of particular matter and attitude, subjective norms, and perceived behavioral control respectively. It was also found that the attitude of outdoor recreationists, subjective norms, and the perceived behavior control of fine particular matter positively influenced behavioral intention. These findings imply that recreation participants are aware of their attitudes toward social, environmental and physical risks, but they are not fully aware in terms of the economic risk of fine particular matter.
Protocol for multiplex (6-plex) measurement of anti-malarial antibodies v1
Authors: Kusi Kwadwo
Published: August 2017

This protocol provides a step-by-step description of the process for attaching proteins to carboxylated microspheres and the optimization processes for mixing different antigen-coupled microspheres and setting up a multiplexed luminex assay
Extracellular enzyme assays (NAG, BG, and CBH) v1
Authors: Maltz Mia , SD Allison , D German , C. Looby
Published: August 2017

We conducted fluorimetric assays for each of three hydrolytic enzymes: b-glucosidase and cellobiohydrolase, and N-acetyl-glucosaminidase in black microplates. We measured fluorescence at 365 nm excitation and 450 nm emission. From each sample, we recorded fluorescence values for MUB substrate (substrate control), homogenate (homogenate control), MUB standards in the presence of maleate buffer (standard), and MUB in the presence of homogenate. We calculated potential extracellular enzyme activity of NAG, BG, and CBH from each litter sample.
Preoperative mechanical prophylaxis in elderly patients with hip fracture v1
Authors: JH Nam , DH Kim , JH Yoo , JH Hwang , JD Chang
Published: August 2017

Background Elderly patients undergoing hip fracture surgery (HFS) are at increased risk of postoperative venous thromboembolism (VTE). Therefore, combined postoperative mechanical and chemical thromboprophylaxis has been routinely performed after HFS in these patients. This retrospective case-control study was conducted to evaluate the additional effectiveness of preoperative mechanical thromboprophylaxis on the prevention of VTE following HFS in elderly patients. Methods Of 539 consecutive patients aged 70 years or older undergoing HFS, 404 (control group) did not receive preoperative mechanical thromboprophylaxis while 135 (study group) received mechanical thromboprophylaxis using an intermittent pneumatic compression device and graduated compression stockings from the time of admission until surgery. All patients received combined postoperative mechanical and chemical thromboprophylaxis following HFS in accordance with the same protocol. The incidence of symptomatic VTE confirmed by clinical symptoms and 3-dimensional CT angiography within one month of surgery was investigated in both groups. Results American Society of Anesthesiologists grade was higher (p=0.016) in the study group and more patients in this group had concomitant cardiovascular and neurologic diseases (p=0.005 and p=0.009, respectively). Meanwhile, more patients in the study group had received anticoagulant medication preinjury owing to comorbidities (39% vs 28%, p=0.025). The overall incidences of symptomatic deep vein thrombosis (DVT) and pulmonary embolism (PE) were 7.4% and 3.7% in the control group and 2.2% and 1.5% in the study group, respectively. On multiple logistic regression, symptomatic DVT significantly reduced in the study group (OR 0.28, p=0.042), meanwhile there was no significant difference in the incidence of symptomatic PE between the two groups (p=0.223). Conclusions Preoperative mechanical thromboprophylaxis may confer an additional benefit by preventing postoperative VTE without adding more risk of perioperative bleeding in elderly patients with hip fracture.
Synthesis of PF-06928215 and analogues v1
Authors: Dakin Les
Published: August 2017

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay Cyclic GMP-AMP synthase (cGAS) initiates the innate immune system in response to cytosolic dsDNA. After binding and activation from dsDNA, cGAS uses ATP and GTP to synthesize 2 ʹ, 3 ʹ -cGAMP (cGAMP), a cyclic dinucleotide second messenger with mixed 2ʹ-5ʹ and 3ʹ-5ʹ phosphodiester bonds. Inappropriate stimulation of cGAS has been implicated in autoimmune disease such as systemic lupus erythematosus, thus inhibition of cGAS may be of therapeutic benefit in some diseases; however, the size and polarity of the cGAS active site makes it a challenging target for the development of conventional substrate-competitive inhibitors. We report here the development of a high affinity (KD = 200 nM) inhibitor from a low affinity fragment hit with supporting biochemical and structural data showing these molecules bind to the cGAS active site. We also report a new high throughput cGAS fluorescence polarization (FP)-based assay to enable the rapid identification and optimization of cGAS inhibitors. This FP assay uses Cy5-labelled cGAMP in combination with a novel high affinity monoclonal antibody that specifically recognizes cGAMP with no cross reactivity to cAMP, cGMP, ATP, or GTP. Given its role in the innate immune response, cGAS is a promising therapeutic target for autoinflammatory disease. Our results demonstrate its druggability, provide a high affinity tool compound, and establish a high throughput assay for the identification of next generation cGAS inhibitors.
TIC no ensino e na formação de professores: reflexões a partir da prática docente
Authors: Vasconcelos Carlos Alberto de , Oliveira Eliane Vasconcelos
Published: August 2017

O presente texto, oriundo das avaliações, indagações e discussões travadas na disciplina Tecnologias da Informação e Comunicação (TIC) no ensino e formação de professores, no ano de 2015, ofertada pelo Programa de Pós-Graduação em Ensino de Ciências e Matemática (PPGECIMA) da Universidade Federal de Sergipe (UFS), tem como objetivo apresentar reflexões e resultados obtidos através dos depoimentos, produções finais elaboradas no curso, assim como seus efeitos para o desenvolvimento do conhecimento dos participantes no tocante às tecnologias na sociedade da informação e, em especial, na formação e prática docente. Para tanto, trabalhou-se com abordagem qualitativa de investigação, tendo como instrumentos para coleta de dados os textos elaborados pelos discentes no final do curso, uma sondagem do material publicado na página do Facebook criada como extensão da sala de aula, a pesquisa bibliográfica e anotações em diário.  Para o estudo e interpretação dos dados optou-se pela análise de conteúdo de Bardin (2011). Nessa disciplina se privilegiou a discussão sobre a importância das TIC e suas influências na/para a sociedade atual, especificamente na educação. Após a análise dos depoimentos dos discentes foi possível concluir que essas reflexões, assim como os debates e as produções desenvolvidas durante o curso, proporcionaram aos participantes momentos de autorreflexão e questionamentos referentes à prática docente com o uso das TIC. De acordo com Nóvoa (2000), essa reflexão sobre a prática deve fazer parte da rotina do professor.
A satisfação com a experiência acadêmica influencia a relação de confiança comportamental com a instituição?
Authors: Santos Marcos Aurélio Corrêa dos , Romeiro Vladimir
Published: August 2017

Este trabalho teve como objetivo verificar a relação existente entre satisfação com a experiência acadêmica discente e confiança comportamental nas instituições de ensino superior privadas do país. A metodologia utilizada foi a pesquisa de natureza quantitativa, de corte transversal único, realizada com estudantes de três IES privadas do estado de São Paulo, sendo duas na capital e uma no interior. O questionário partiu de uma escala validada com três fatores independentes: satisfação com o curso, satisfação com a instituição de ensino superior e oportunidades de desenvolvimento; e um dependente: confiança comportamental. Os resultados apontam que a satisfação com a instituição foi o fator que mostrou influenciar positivamente a confiança comportamental para com a instituição, não sendo possível confirmar as hipóteses com relação a satisfação com o curso e, oportunidade de desenvolvimento.
Levantamento etnobotânico de espécies arbóreas no assentamento Tabuleiro Grande, Apodi, Rio Grande do Norte
Authors: Cordeiro Mônica Costa , Botrel Rejane Tavares , Holanda Alan Cauê
Published: August 2017

Objetivou-se realizar um levantamento etnobotânico no Projeto de Assentamento Tabuleiro Grande, localizado em Apodi, Rio Grande do Norte, contribuindo para o resgate do conhecimento popular discutindo as implicações do uso da vegetação arbórea na conservação dos recursos florestais. A condução do estudo foi por meio da observação direta e entrevistas semiestruturadas (21 entrevistas). Para análise dos dados foram feitas abordagens qualitativas (acesso a informações subjetivas) e quantitativas (Valor de Uso; índices de diversidade de Shannon e de equabilidade de Pielou). Foram mencionadas no levantamento 57 espécies arbóreas, entre nativas e exóticas, distribuídas em 26 famílias e enquadradas nas seguintes categorias de uso: Madeira (móveis e construção), Medicina/Higiene, Apicultura, Lenha, Veterinária Popular, Forragem, Alimentação Humana e Outros. Com os resultados obtidos, conclui-se que a comunidade estudada possui conhecimento sobre um grande número de espécies arbóreas. No entanto, no que diz respeito a “uso”, poucas espécies são, de fato, utilizadas. De forma geral, o conhecimento popular na comunidade está mantido com uma pequena parcela dos entrevistados e não é repassado, tendendo a tornar-se cada vez mais escasso.
Ethnobotanical survey of tree species in the Tabuleiro Grande settlement, Apodi, Rio Grande do Norte
Abstract: The aim this study was to realize ethnobotanical survey in Settlement Tabuleiro Grande Project, located in Apodi - RN, to contribute to the rescue of popular knowledge and discuss the implications of the use of trees in the conservation of forest resources. The conduct of the study was through direct observation and semi-structured interviews (21 interviews). Data analysis were made qualitative approaches (access to subjective information) and quantitative (use value -VU, Shannon diversity and Pielou evenness indexes). Were mentioned in the survey 57 tree species native and exotic, distributed in 26 families and classified in the following categories of use: wood (furniture and construction), Medicine / hygiene, Beekeeping, Firewood, Popular Veterinary, Fodder, Food and Others. With the results, it is concluded that the studied community has knowledge of a large number of tree species. However, with regard to "use", few are actually used. In general, the popular knowledge in the community is maintained with a small portion of respondents and is not passed, tending to become increasingly scarce.
Habilidades visoperceptuales en niños escolarizados de 7 a 12 años con ambliopía refractiva
Authors: Jadue Jadue Tomás Cristóbal , Figueroa O. Luisa Fernanda
Published: August 2017

La percepción visual es una habilidad que involucra una serie de subhabilidades relacionadas, que interactúan entre sí para analizar, integrar y sintetizar la información visual de manera eficiente. Objetivo general: determinar el estado de las habilidades visoperceptuales en niños escolarizados entre 7 y 12 años con ambliopía refractiva, residentes de Bogotá. Materiales y métodos: se desarrolló un estudio observacional descriptivo; así mismo, se contribuyó en la obtención de la muestra al efectuar tamizaje visual a los estudiantes del grupo de edad seleccionado (examen completo, incluida cicloplejia, a los estudiantes positivos posibles ambliopes en el tamizaje) y al aplicar la prueba TVPS-3 a los niños con diagnóstico de ambliopía. Resultados: las habilidades visoperceptuales de cierre visual, figura fondo, constancia de forma y relaciones espaciales se presentaron con mayor frecuencia por debajo de los valores normales. Conclusiones: se encontró que algunas de las habilidades visoperceptuales en los pacientes ambliopes de la muestra estaban por debajo de los valores considerados normales.
Perfil de la salud visual y ocular de los niños de dos centros de desarrollo infantil de Pereira, Colombia
Authors: Márquez Galvis Mónica Marlene , Cáceres Díaz Mayra Catalina
Published: August 2017

La detección de alteraciones en el desarrollo visual de los niños es una de las misiones del optómetra, para prevenir la aparición y complicación de los problemas visuales. Objetivo: identificar el estado refractivo, motor y patológico del segmento anterior y posterior en los niños de dos centros de desarrollo infantil (CDI) de Pereira, Colombia. Materiales y métodos: estudio descriptivo retrospectivo, de corte transversal, en el cual se describen las características sociodemográficas y la morbilidad visual y ocular de los niños, de estrato socioeconómico 0 y 1, según las historias clínicas de exámenes efectuados en los años 2012 y 2013 y los niños examinados en los años 2014 y 2015. Resultados: se evaluaron 718 sujetos entre los dos CDI, el 46,1 % de género femenino y 53,9 % de género masculino, con edad media de 46,2 meses (DS ±12,5). El grupo étnico con mayor representación fue el mestizo (83,7 %), seguido del afrocolombiano (13,8 %) y el indígena (2,5 %). El promedio del equivalente esférico (M) fue de +0,34 D y del cilindro, de 0,17 D (J0), con una tendencia del eje con la regla; el estado refractivo más prevalente fue la emetropía (66,0 %), seguido por la hipermetropía (16,0 %), el astigmatismo (15,0 %) y la miopía (3,0 %). La prevalencia de anisometropía fue del 5,2 %; de estrabismo, 1,1 %; de blefaritis, 4,0 %, y de conjuntivitis bacteriana, 1,0 %. Conclusiones: los diagnósticos más frecuentes fueron la emetropía, la ortoforia y la blefaritis, datos que difieren, en su mayoría, con los encontrados en otros estudios étnicos reportados en otros países.
Contributions of occupational health and safety to the quality of working life: An analytical reflection
Authors: Valero Pacheco Ivonne Constanza , Riaño-Casallas Martha Isabel
Published: August 2017

La finalidad de la Calidad de Vida Laboral (CVL) y la Seguridad y Salud en el Trabajo (SST) es el bienestar, la productividad y la protección del trabajador en su medio laboral. Por tal razón, el objetivo del presente trabajo es comprender la relación entre estos dos conceptos y, por ende, deducir la significancia de tal nexo. El estudio se realiza bajo un enfoque cualitativo-descriptivo, por su carácter interpretativo-inductivo, y con diseño hermenéutico mediante, cual pretende comprender, explicar e interpretar las teorías propuestas para CVL y sus relaciones con la SST como factor determinante de esta. Resultado de dicho análisis se presenta la evolución de los conceptos, sus interrelaciones y tres aproximaciones desde la SST. La CVL tiene un carácter integral y multidimensional; por lo tanto, la intervención a problemáticas que afecten el bienestar de los trabajadores en su entorno laboral y familiar se complementa con acciones de SST.