bluuebunny/crossref_metadata_2025 huggingface dataset:
Siblings’ life aspirations in the context of Duchenne muscular dystrophy: a mixed-methods case-control study
Authors: Schwartz Carolyn E. , Biletch Elijah , Stuart Richard B. B. , Rapkin Bruce D.
Published: September 2022

Background

The inevitable and progressive loss of independence in Duchenne Muscular Dystrophy (DMD) patients may have an impact on their siblings’ life aspirations. The present cross-sectional case-control study investigated how aspirations differed between brothers and sisters of people with DMD and a stratified comparison group of nationally representative children/adults.

Methods

A web-based survey was administered October through December 2020. Aspirations were measured using qualitative (open-ended) and quantitative (closed-ended) questions. Qualitative prompts asked participants about wishes, goals, and how they define quality of life (QOL) and were coded by six trained raters. Quantitative questions included 29 closed-ended goal-delineation items from the QOL Appraisal Profilev2. These data were analyzed using multivariate models adjusting for propensity scores (demographic differences) and testing for the effects of role (sibling or comparison), age, and role-by-age interactions.

Results

The study sample of DMD sibling (n = 349) and comparison (n = 619) participants provided open-ended data on 968 wishes statements, 390 QOL-definition statements, and 328 goals statements. Inter-rater reliability (kappa = 0.77) reflected good agreement between raters. Results of both open-ended and closed-ended data, and of both unadjusted and adjusted analyses suggested that DMD siblings, with age, were more focused on DMD-related, family/community, intimacy, and work concerns than their peers. They were less focused on improving mood, independence, pragmatics, or subtle fine-tuning of problem-solving in life. In contrast, the comparison group was more focused on goals related to growth, purpose, and reflection. Some group differences were amplified amongst older siblings.

Conclusion

This is the first study to evaluate DMD siblings’ aspirations in comparison to their peers. While there were many similarities between groups, the differences in aspirations between DMD siblings and their peers encompassed not just DMD, family/community, and intimacy, but also more work concerns. Directions for future quantitative and qualitative research are discussed.
Intracranial wide neck aneurysms: clinical and angiographic outcomes of endovascular management
Authors: Morsy Abdalla , Mahmoud Mohamed , Abokresha Ahmad Elsayed , Moussa Ahmad A. , Abdel-Tawab Mohamed , Othman Moustafa , Moubark Mahmoud A.
Published: September 2022

Background

The treatment of intracranial wide neck aneurysms (WNAs) is usually difficult, hence several endovascular techniques were developed. This study aims to assess the clinical and angiographic imaging outcome of endovascular management of intracranial wide neck aneurysm. Forty patients were referred to the neuro-endovascular unit, at our hospital, each with a wide neck aneurysm. They were assessed regarding clinical presentation, aneurysm size, the character of the aneurysm, and the age and sex of the patient. Post-procedural, clinical, and angiographic outcomes of the patients who underwent endovascular intervention were reviewed.

Results

In this study, the mean aneurysmal neck was 5.4 ± 1.6 mm (mm). Endovascular intervention was carried out in all 40 patients in the form of simple coiling in 3 patients, double-catheter technique in 5 patients, balloon-assisted coiling (BAC) in 16 patients, stent-assisted coiling (SAC) in 13 patients, and flow diverter (FD) in 3 patients. Regarding clinical outcome, 4 patients had unfavorable outcome (the modified Rankin Scale, mRS > 2) at presentation and 3 patients at discharge. There was no unfavorable clinical outcome at 6- and 12-month follow-ups. Overall angiographic outcome at 1-year follow-up, 37/40 aneurysms (92.5%) had complete occlusion while two aneurysms had neck recurrence and one aneurysm had neck recanalization.

Conclusion

The current endovascular techniques in the treatment of WNAs are considered effective, feasible, and safe.
The illuminated airway: flexible bronchoscopic removal of an aspirated LED bulb in an adolescent boy
Authors: Mishra Mayank , Sindhwani Girish , Darbari Anshuman
Published: September 2022

Background

Foreign body aspiration is a common but serious pediatric medical emergency. A high index of suspicion, timely diagnosis and early bronchoscopic intervention can be life-saving in most cases.

Case presentation

We report the case of a 12-year-old boy who was symptomatic with recurrent chest infections for the last 3 years. Imaging identified a radio-opaque FB in the left mainstem bronchus. Subsequently, flexible bronchoscopic evaluation was performed under general anesthesia using laryngeal mask airway, and a light-emitting diode bulb was retrieved using flexible biopsy forceps.

Conclusion

The case highlights aspiration of a rare foreign body that went unnoticed for a long duration in a relatively higher pediatric age group child, and also emphasizes the role of bronchoscopy in managing the condition.
Treatment Burden of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Randomized Study
Authors: Maniatis Aristides K , Carakushansky Mauri , Galcheva Sonya , Prakasam Gnanagurudasan , Fox Larry A , Dankovcikova Adriana , Loftus Jane , Palladino Andrew A , de los Angeles Resa Maria , Turich Taylor Carrie , Dattani Mehul T , Lebl Jan
Published: September 2022

Context

Somatrogon is a long-acting recombinant human growth hormone treatment developed as a once-weekly treatment for pediatric patients with growth hormone deficiency (GHD).

Objective

Evaluate patient and caregiver perceptions of the treatment burden associated with the once-weekly somatrogon injection regimen vs a once-daily Somatropin injection regimen.

Methods

Pediatric patients (≥3 to <18 years) with GHD receiving once-daily somatropin at enrollment were randomized 1:1 to Sequence 1 (12 weeks of once-daily Somatropin, then 12 weeks of once-weekly somatrogon) or Sequence 2 (12 weeks of once-weekly somatrogon, then 12 weeks of once-daily Somatropin). Treatment burden was assessed using validated questionnaires completed by patients and caregivers. The primary endpoint was the difference in mean overall life interference (LI) total scores after each 12-week treatment period (somatrogon vs Somatropin), as assessed by questionnaires.

Results

Of 87 patients randomized to Sequence 1 (n = 43) or 2 (n = 44), 85 completed the study. Once-weekly somatrogon had a significantly lower treatment burden than once-daily Somatropin, based on mean overall LI total scores after somatrogon (8.63) vs Somatropin (24.13) treatment (mean difference –15.49; 2-sided 95% CI –19.71, –11.27; P < .0001). Once-weekly somatrogon was associated with greater convenience, higher satisfaction with treatment experience, and less LI. The incidence of treatment-emergent adverse events (TEAEs) for Somatropin and somatrogon was 44.2% and 54.0%, respectively. No severe or serious AEs were reported.

Conclusion

In pediatric patients with GHD, once-weekly somatrogon had a lower treatment burden and was associated with a more favorable treatment experience than once-daily Somatropin.
The diagnosis and treatment of primary dysmenorrhea
Authors: Obuchowska Karolina , Obuchowska Aleksandra , Standyło Arkadiusz , Gorczyca Kamila , Wójcik-Grudzień Justyna , Ozga-Stachurska Alicja , Pawłowska Paulina , Rozenbajgier Martyna , Żelazny Przemysław , Filipczak Joanna , Kimber-Trojnar Żaneta , Leszczyńska-Gorzelak Bożena
Published: September 2022

Primary dysmenorrhea is defined as pain in the pelvic area that occurs for no specific reason during menstrual cycle. Dysmenorrhea occurs in 50% to 90% of adolescent girls and women of reproductive age which makes it one of the most common causes of pelvic pain in women. The mechanism of this condition is overproduction of prostaglandins by the endometrium, causing uterine hypercontractility, thereby leading to uterine muscle ischemia, hypoxia and pain. Dysmenorrhea significantly reduces the quality of women life, often making it impossible to perform daily activities and, in addition, it may cause a mental stress that makes both professional and school life difficult. Despite this, females often consider these symptoms as a normal part of their menstrual cycle, which makes this disease underrated and untreated. Dysmenorrhea can be treated in a various ways such as non-pharmacological, pharmacological and surgical. However, women with a typical history of primary dysmenorrhea can commence empirical therapy without any additional tests. Hormonal contraception and nonsteroidal antiinflammatory drugs have proved to be effective in this treatment. However, if conventional treatment is contraindicated, alternative treatments such as topical heat, lifestyle modification, transcutaneous electrical nerve stimulation, dietary supplements, acupuncture, and acupressure may be used. Surgical treatment is possible, but it is used rarely and only in severe cases of treatment-resistant dysmenorrhea. However, it should be emphasized how important it is to exclude secondary causes of dysmenorrhea.
Can we expect re-emergence of infectious diseases in the near future?
Authors: Pruszyński Jacek , Cianciara Dorota , Grudziąż-Sękowska Justyna , Włodarczyk-Pruszyńska Inga , Kobuszewski Bartosz , Zgliczyński Wojciech , Pruszyńska Irena
Published: September 2022

Ever since Hippocrates expressed the view that environmental factors can influence disease incidence, attempts have been made to link the emergence of disease, especially outbreaks of infectious diseases, with the various factors that contribute to their occurrence. Among the possible causes favoring the spread of pathogens and the increase in the incidence of infectious diseases, environmental and social conditions are mentioned. An unprecedented set of new conditions has made the human population more vulnerable and more susceptible to infectious diseases than ever before. It is possible that the observed contemporary patterns of development and spread of infectious diseases may be seen as heralds of a new stage of epidemiological transformation characterized by an increased risk of infectious disease epidemics. In past centuries, one of the hallmarks of infectious disease plagues has been their unpredictability. Currently, warning forecasts prepared by scientists do not always translate into preventive measures.
Thematic Review: Think again: patronage, governance and the smarter state
Authors: Flinders Matthew , Matthews Felicity
Published: September 2022

The concept of ‘governance’ denotes a shift in the distribution of power within and beyond modern democracies and state systems. At the heart of this shift lies a normative preference for disaggregating large bureaucratic state structures into smaller, more flexible, single-purpose organisational units. This process poses distinct questions regarding the capacity of elected politicians to control or coordinate this sphere of delegated governance. The central argument of this article is as simple as ABC (that is, agencies, boards and commissions): patronage is a critical political resource for elected politicians that should not automatically be derided as corrupt, unfair or nepotistic.
Growing Up in Québec: the experience of a pilot study
Authors: Fontaine Catherine , Tu Mai Thanh , Desrosiers Hélène , Provençal Delphine , Illick Nancy , Perron Bertrand
Published: September 2022

Growing Up in Québec, also known as the Québec Longitudinal Study of Child Development, 2nd edition (QLSCD 2), is a prospective cohort that began in spring 2021. Its goal is to follow the development of Québec children from the age of five months to adulthood in about 4,500 families. It is conducted by the Institut de la statistique du Québec and is based on the Québec Longitudinal Study of Child Development, 1st edition (QLSCD 1), which began in 1998 and is still ongoing. This article describes the Growing Up in Québec pilot study started in 2018, focusing on its objectives and key stages of completion, namely content selection, recruitment strategies and the retention plan, collection methods, adjustments to strategies made during collection, and methodology, including the construction of a socio-economic poverty indicator for population stratification. The article continues by presenting pilot results and their implications for the main survey. It ends with recommendations from the pilot study, exemplifying the wealth of experience gained from it.
Becoming a volunteer: first impressions of volunteering in community food projects
Authors: Curry Nigel
Published: September 2022

In this practice paper, a number of ‘first impressions’ from practical volunteering in community food projects are explored through academic and grey literature: the complexity of decision making; valorising the symptoms rather than the causes of problems; shunting risk; and the marketisation of both volunteering and community food projects. Volunteers, as policy takers, can only soften rather than resolve these issues. The state’s view of the advantages of using volunteers corresponds to the main difficulties of volunteering, for volunteers.
La presencia de soldados y veteranos hispanos en Italia en época romana (siglos I-II d. C.)
Authors: Ortiz Córdoba José
Published: September 2022

La participación de hispanos en el ejército romano fue una constante desde época republicana y se intensificó tras el final de las guerras civiles y la instauración del Principado. La mayoría de estos soldados sirvió en las regiones fronterizas del Imperio y en la propia península ibérica, aunque la documentación literaria y epigráfica constata la presencia de un pequeño grupo de milites y veterani de origen hispano en Roma y en varias ciudades del centro y norte de Italia durante los siglos I y II d. C. El objetivo de este trabajo es recopilar y analizar las referencias relativas a estos soldados, prestando especial atención al estudio de elementos tan importantes como la onomástica, el origen, la trayectoria militar o las causas que motivaron su presencia en Italia.
Produtividade, custo e rentabilidade de couve produzida sob túnel baixo
Authors: Da Silva Ponce Franciely , De Lima Toledo Claudia Aparecida , Gawski Casagrande Jéssica , Grzebieluckas Cleci , Roggia Zanuzo Márcio , Seabra Júnior Santino
Published: September 2022

A couve é uma hortaliça bastante popular no mundo, no entanto a ocorrência de insetos-praga pode comprometer a produção e a rentabilidade da cultura. Desta forma, objetivou-se avaliar a produtividade e a rentabilidade de dois híbridos de couve cultivados sob túnel baixo e campo aberto. O estudo foi realizado utilizando-se dois híbridos de couve folha Hi-crop e Kobe e seis ambientes: túneis baixos cobertos com agrotêxtil na gramatura 15 g/m2, organza branca na gramatura 47 g/m2, tela vermelha (Chromatinet® 35%), tela termorefletora prata (Aluminet® 35%), tela preta (Sombrite® 35%) e campo aberto, com quatro repetições. Foram realizadas seis colheitas e a somatória das médias foi utilizada para a estimativa da produtividade para cada ambiente. Calculou-se o custo operacional total e os indicadores econômicos referentes ao cultivo de cada híbrido e ambiente, estimando-se o lucro operacional, índice de lucratividade (%), margem bruta (%), ponto de nivelamento em quilos por hectare e ponto de nivelamento para estabelecimento do valor a ser aplicado na comercialização do maço do produto. Ambos os híbridos apresentaram elevada produtividade e índices de rentabilidade em todos os ambientes. O híbrido ‘Hi-crop’ apresentou a maior produtividade quando cultivado sob túnel de organza. O uso de ambiente protegido proporcionou redução na necessidade de pulverização de inseticida o que refletiu na produtividade e consequentemente na rentabilidade dos cultivos.
Where Visions Meet: Ellen Swallow Richards and Maria Montessori
Authors: McGregor Sue L.T. , Ryan Longo Gail T.
Published: September 2022

Home economics (now called family and consumer sciences [FCS] in the United States) and the Montessori education method were both started by strong women pioneers. American-born Ellen Swallow Richards (home economics founder) graduated from Vassar College (chemistry) the same year that
Maria Montessori was born in Italy–1870. Both women were scientists and Richards was the first woman to graduate from the Massachusetts Institute of Technology (MIT) (sanitary engineering). Montessori was interested in engineering but completed studies in medicine (pediatrics) and psychology.
She was one of the first female doctors in Italy (Association Montessori Internationale, 2020; Kramer, 2017; McGregor, 2020).
Off the Mat: The Practice of Yoga and Mindfulness To Foster Hope and Resilience for Adolescents in Homes and Classrooms
Authors: Peterson Treisha K. , Dutton Catherine
Published: September 2022

An individual's sense of self and identity is a developmental cognition informed by the balance of intrinsic and extrinsic motivation, proximal others, and systems of belief. Today's identity-seeking adolescent may internalize pressures and expectations from a growing base of social narratives that extends beyond the reach of family and friends. Cultivating daily practices that foster hope and resilience can support positive well-being outcomes for individuals, families, and communities who are faced with distress or traumatic events. Overall well-being within a classroom can be nourished through collaborative growth mindsets, positive coping skills, and cognitive reappraisals. Hope and resilience can be fostered through daily habits of awareness, gratitude, and simple meditation exercises. An off-the-mat approach to the practice of yoga-inspired philosophy can be used in the classroom or at home to support the skills necessary to foster the constructs of hope, develop resilience, and support flexible cognition that builds and sustains positive social, emotional, mental, and physical well-being.
Advocating for Social Health Education: We Need It Now More Than Ever
Authors: Ramsey Elizabeth
Published: September 2022

Social Health education is vital because students learn how to regulate their emotions, develop healthy relationships, and gain effective communication styles; therefore, knowing how to advocate for it is equally important. This article outlines simple steps to help any family and consumer
sciences (FCS) professional advocate for their field of study. The steps that led to the sponsorship of a legislative bill that requires Social Health education for all Tennessee middle schools are described. Although the the bill did not pass second rounds, the attention that Social Health
gained through the advocating process is noteworthy. The process for advocating for Social Health is presented in easy-to-replicate steps that include recognizing the need, making the case, implementing the content, bringing awareness, approaching legislators, and rallying community support.
The Assessment of Driving Fitness Using an On-Road Evaluation in Patients With Cirrhosis
Authors: Tandon Puneeta , Pidborochynski Tara , Abraldes Juan G. , Carbonneau Michelle , Newnham Kimberly , Bailey Robert , Ismond Kathleen P. , Bajaj Jasmohan S. , Dobbs Bonnie
Published: September 2022

INTRODUCTION:

The association between cirrhosis and driving performance is of particular clinical relevance because of the life-threatening safety issues both for the driver with cirrhosis and the general public. Study aims were to assess (i) driving competency through the use of an in-office computerized battery and on-road driving assessment (DriveABLE) and (ii) the association between minimal hepatic encephalopathy (MHE), in-office paper-pencil tools, and additional measures (e.g., frailty, depression, cognitive testing) with unsafe driving.

METHODS:

Patients were prospectively recruited from 2 tertiary care liver clinics. In-office tests and in-office and on-road assessments of driving competence were completed. The χ2 test and 1-way analysis of variance were used to analyze differences among those with and without MHE. Logistic regression was used to evaluate predictors of an indeterminate/fail result on the in-office computerized driving assessment battery (DriveABLE Cognitive Assessment Tool [DCAT]).

RESULTS:

Eighty patients participated with a mean age of 57 years, 70% male, 75% Child-Pugh B/C, and 36% with a history of overt hepatic encephalopathy. Thirty percent met MHE criteria on both the psychometric hepatic encephalopathy score and the Stroop app tests. Only 2 patients (3%) were categorized as “unfit to drive” in the on-road driving test, one with MHE and the other without. Fifty-eight percent of the patients were scored as indeterminate/fail on the DCAT. This corresponded to a higher mean number of on-road driving errors (5.3 [SD 2.1] vs 4.2 [SD 1.6] in those who passed the DCAT, P = 0.01). Older age (odds ratio 1.3; confidence interval 1.1, 1.5; P = 0.001) and MHE by Stroop/psychometric hepatic encephalopathy score (odds ratio 11.0; confidence interval 2.3, 51.8; P = 0.002) were independently predictive of worse performance on the DCAT.

DISCUSSION:

Worse performance in in-office testing was associated with worse scores on a computerized driving assessment battery and more on-road driving errors, but in-office tools were insufficient to predict on-road driving failures. A diagnosis of MHE should not be used alone to restrict driving in patients with cirrhosis. At-risk patients require on-road driving tests under the supervision of driving regulatory agencies. Future studies should continue to refine and evaluate in-office or at-home testing to predict driving performance.
Modest Conformity Between Self-Reporting of Bristol Stool Form and Fecal Consistency Measured by Stool Water Content in Irritable Bowel Syndrome and a FODMAP and Gluten Trial
Authors: Nordin Elise , Hellström Per M. , Brunius Carl , Landberg Rikard
Published: September 2022

INTRODUCTION:

Altered bowel habits constitute a criterion of irritable bowel syndrome (IBS), with the Bristol Stool Form Scale (BSFS) as the recommended tool for assessment of fecal consistency. However, BSFS is devoid of a comprehensive objective evaluation in subjects with IBS. Therefore, we aimed to evaluate the concordance between subjective reporting of BSFS and objective stool water content in subjects with IBS. Furthermore, we evaluated whether intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) or gluten would affect stool water content.

METHODS:

Data from a previous crossover trial in IBS with 1-week provocations of FODMAPs, gluten, or placebo were subanalyzed. After each intervention, fecal consistency was subjectively assessed using the BSFS and stool samples were collected. The stool water content was analyzed, where ≤68.5% water content was classified as hard stool, while ≥78% was classified as diarrhea.

RESULTS:

BSFS correlated to stool water content (r = 0.36, P < 0.0001). The BSFS score increased in parallel with increasing water content, but with considerable overlap between BSFS scores. Stool water content differed between the BSFS categories 1–2, 3–5, and 6–7 (hard, normal, and loose, respectively) (P < 0.0001). For BSFS categories 1–2, 77% had water content ≤68.5%, whereas for BSFS categories 6–7, 52% had water content ≥78%. There was no difference in stool water content after consumption of FODMAPs, gluten, or placebo (P = 0.94).

DISCUSSION:

Subjective reporting of BSFS conforms only modestly with stool water content in IBS, warranting caution when subtyping IBS according to the BSFS. High intake of FODMAPs and gluten does not affect stool water content.
Isolated Hepatitis B Core Antibody Positivity and Long-Term Liver-Related Mortality in Korea: A Cohort Study
Authors: Sohn Won , Chang Yoosoo , Cho Yong Kyun , Hong Yun Soo , Ryu Seungho
Published: September 2022

INTRODUCTION:

Whether isolated hepatitis B core antibody (anti-HBc) positivity is a risk factor for long-term liver-related outcomes in hepatitis B virus (HBV)-endemic areas remains unclear. We aimed to investigate liver-related and liver cancer mortality of isolated anti-HBc positivity in Korean adults.

METHODS:

A cohort study comprised 609,299 Korean adults who underwent hepatitis B serologic markers, as a part of health examination. Liver-related and liver cancer mortality were determined using the National Death Records.

RESULTS:

During a median follow-up of 9.0 years (interquartile range, 5.5–13.7 years), 554 liver-related deaths were identified (liver-related mortality, 9.6 cases per 105 person-years). The prevalence of isolated anti-HBc positivity was 3.8% (n = 23,399) and was age-dependent. After adjustment for age, sex, and other confounders, hazard ratios (95% confidence interval) for liver-related mortality in isolated anti-HBc-positive and hepatitis B surface antigen–positive subjects compared with HBV-unexposed subjects were 1.69 (1.22–2.33) and 27.02 (21.45–34.04), respectively. These associations were pronounced in the analyses using liver cancer mortality as an outcome. Among isolated anti-HBc-positive patients, the risks of liver-related and liver cancer mortality were significantly higher in those with high fibrosis-4 scores compared with patients unexposed to HBV with the multivariable-adjusted hazard ratios (95% confidence interval) of 15.59 (9.21–26.37) and 72.66 (36.96–142.86), respectively.

DISCUSSION:

In this cohort of Korean adults, isolated anti-HBc positivity was associated with an increased risk of liver-related and liver cancer mortality, especially when accompanied by a high fibrosis score. Isolated anti-HBc positivity may be an independent risk factor for liver-related outcomes, especially in high-endemic areas.
Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database
Authors: Zaccherini Giacomo , Baldassarre Maurizio , Tufoni Manuel , Nardelli Silvia , Piano Salvatore , Alessandria Carlo , Neri Sergio , Foschi Francesco Giuseppe , Levantesi Fabio , Bedogni Giorgio , Domenicali Marco , Bernardi Mauro , Caraceni Paolo ,   for the ANSWER Study Investigators
Published: September 2022

INTRODUCTION:

We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.

METHODS:

The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.

RESULTS:

The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167–0.359], P < 0.001).

DISCUSSION:

Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.
Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis
Authors: Stanich Peter P. , Elgindi Dareen , Stoffel Elena , Koeppe Erika , Bansal Ajay , Stetson Rachel , Collins Debra L. , Clark Dana Farengo , Karloski Eve , Dudley Beth , Brand Randall E. , Hall Michael J. , Chertock Yana , Sullivan Brian A. , Muller Charles , Hinton Alice , Katona Bryson W. , Kupfer Sonia S.
Published: September 2022

INTRODUCTION:

Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia.

METHODS:

This was a retrospective analysis of colonoscopy outcomes in patients with germline CDH1 pathogenic/likely pathogenic variants.

RESULTS:

Eighty-five patients were included with a mean age of 46.9 years. Initial colonoscopy found adenomatous polyps in 30 patients (35.3%), including advanced adenomas in 9 (10.6%). No colorectal cancers were identified on index or subsequent colonoscopies (when available).

DISCUSSION:

CDH1 carriers have colorectal neoplasia identified at similar rates as in the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population.
13C-methacetin breath test predicts survival in patients with hepatocellular carcinoma undergoing transarterial chemoembolization
Authors: Gairing Simon Johannes , Kuchen Robert , Müller Lukas , Cankaya Alper , Weerts Jan , Kapucu Akin , Sachse Simon , Zimpel Carolin , Stoehr Fabian , Pitton Michael B. , Mittler Jens , Straub Beate Katharina , Marquardt Jens Uwe , Schattenberg Jörn M. , Labenz Christian , Kloeckner Roman , Weinmann Arndt , Galle Peter Robert , Wörns Marcus-Alexander , Foerster Friedrich
Published: September 2022

Introduction:

The 13C-methacetin breath test (13C-MBT) is a dynamic method for assessing liver function. This proof-of-concept study aimed to investigate the association between 13C-MBT values and outcome in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).

Methods:

A total of 30 HCC patients were prospectively recruited. Of these, 25 were included in the baseline, 20 in longitudinal analysis. 13C-MBTs were performed before the first and second TACE. Patients were followed for at least one year.

Results:

At baseline, median 13C-MBT value was 261 µg/kg/h (interquartile range (IQR) 159 - 387). 13C-MBT, albumin-bilirubin (ALBI), Child-Pugh and Model for End Stage Liver Disease (MELD) scores were associated with overall survival (OS) in extended univariable Cox regression (13C-MBT: standardized hazard ratio (sHR) 0.297, 95% confidence interval (CI) 0.111 - 0.796; ALBI score: sHR 4.051, 95% CI 1.813 - 9.052; Child-Pugh score: sHR 2.616, 95% CI 1.450 - 4.719; MELD: sHR 2.781, 95% CI 1.356 – 5.703). Using a cut-off of 140 µg/kg/h at baseline, 13C-MBT was associated with prognosis (median OS 28.5 months (95% CI 0.0 – 57.1) vs 3.5 months (95% CI 0.0 – 8.1), Log-Rank p < 0.001). Regarding prediction of 90-day mortality after the second 13C-MBT, the relative change in 13C-MBT values yielded an area under the ROC curve of 1.000 (p = 0.007).

Conclusions:

Baseline and longitudinal 13C-MBT values predict survival HCC patients undergoing TACE. The relative change in 13C-MBT value predicts short-term mortality and may assist in identifying patients who will not benefit from further TACE treatment.
Reevaluation of gastric cancer screening by Levin’s equation
Authors: Ishii Naoki , Shiratori Yasutoshi , Yano Takahiko , Konai Mimoe , Arai Yuki , Hamada Jun , Maekawa Hisato , Omata Fumio
Published: September 2022

INTRODUCTION:

This study aimed to reevaluate the effectiveness of fluoroscopy and endoscopy in reducing gastric cancer mortality at the population level.

METHODS:

Crude and age-adjusted mortality rates of gastric cancer and the introduction rates of gastric cancer screening were extracted from the Cancer Registry and Statistics database. The population-attributable risk (PAR) percent (PAR%) of no screening for gastric cancer mortality was calculated using Levin’s equation. The PAR of each mortality rate in the no screening group was estimated as follows: mortality×PAR%. The Jonckheere-Terpstra test for trends and linear regression were performed to compare PAR of gastric cancer mortality rates among the decades.

RESULTS:

The PAR of crude and age-adjusted mortality rates in the no screening group significantly decreased in the total population (P for trend <0.001), as well as individually in the male (P for trend <0.001) and female (P for trend <0.001) populations. The PAR of crude mortality rate in the female population significantly decreased in 2000–2009 and 2010–2019, compared with that in 1980–1989. There was no significant difference in the PAR of crude mortality rate in the male population among the decades. The PAR of age-adjusted mortality rate significantly decreased in 2000–2009 and 2010–2019, compared with that in 1980–1989, in the male and female populations.

DISCUSSION:

PAR% and PAR of no screening for gastric cancer mortality could be estimated using Levin’s equation and the effectiveness of the present gastric cancer screenings with fluoroscopy and endoscopy has been decreasing, especially in the female population.
Neurorehabilitation bei schwerer Bewusstseinsstörung
Authors: Herzog J.
Published: September 2022

Zusammenfassung Die vorliegende Übersicht soll die wichtigsten Aspekte im klinischen Umgang mit der prolongierten, schweren Bewusstseinsstöung (SBS) zusammenfassen. Ausgehend von den klinischen Syndromen und der interdisziplinären Befunderhebung werden Assessments dargestellt, die zur Statuserhebung und Verlaufsbeurteilung geeignet sind. Auf die Rolle laborchemischer, elektrophysiologischer bzw. bildgebender Zusatzdiagnostik zur Beurteilung der Hirnschädigung und zur Prognoseabschätzung wird ebenso eingegangen. Neurorehabilitative Funktionstherapien sowie medikamentöse, nicht invasive und invasive Stimulationsverfahren werden vorgestellt. Abschließend werden – unter Berücksichtigung der aktuellen Evidenz – die bislang vorliegenden Erkenntnisse zum mittel- und langfristigen Erkrankungsverlauf dieser Patienten zusammengefasst. Schlüsselwörter: Koma, Syndrom reaktionsloser Wachheit, minimal responsives Syndrom, Locked-in-Syndrom, akinetischer Mutismus, Glasgow Coma Scale, Coma Recovery Scale, Mobilisierung, multisensorische Stimulation, tiefe Hirnstimulation, transkranielle Gleichstromstimulation Abstract This review aims to summarize the most important aspects in the clinical management of prolonged severe loss of consciousness. After a short overview of the clinical syndromes, interdisciplinary assessments are presented that are suitable for status elicitation and course assessment. The role of laboratory, electrophysiological, or additional imaging diagnostics in assessing brain injury and estimating prognosis will also be addressed. Neurorehabilitative functional therapies as well as pharmaceutical, non-invasive and invasive stimulation methods are presented. Finally, taking into account the current evidence, the available findings on the medium- and long-term course of disease in these patients are summarized. Keywords: coma, unresponsive wakefulness syndrome, minimally responsive syndrome, locked-in syndrome, akinetic mutism, Glasgow Coma Scale, Coma Recovery Scale, mobilization, multisensory stimulation, deep brain stimulation, transcranial direct current stimulation
ANALISIS MIRROR PERDAGANGAN BARANG INDONESIA DENGAN THAILAND TAHUN 2018
Authors: Suryono Agus
Published: September 2022

International trade is one of the country's foreign exchange sources. As a source of foreign exchange, many parties are involved in international trade, not only exportir, but also importir and government stakeholders from various countries. In fulfilling the needs of international trade statistics for policy, negotiation and main objectives of foreign exchange income, it is necessary to have the quality of international trade data that has certain standards. This analysis aims to determine the quality of trade in Indonesian goods with the trade of goods from Thailand, using the mirror analysis method. In addition, this paper also examines the reasons behind the incompatibility of export and import data from the two countries.To get a complete picture of this paper, the authors conducted a trade calculation between Indonesia and Thailand to get the differences between the two countries and present it with 2 digit Harmonize System (HS) and 6 digit HS details.
Utang Pemerintah dan Fiscal Sustainability dalam Paradigma Ricardian Fiscal Regime di Indonesia
Authors: Insanu Fana Mustika
Published: September 2022

Ricardian fiscal regime is a paradigm where the government are "well behaved" dan rational in managing debt. This paradigm can be used to assess fiscal sustainability which is reflected through the positive effect between government debt and the primary balance ratio. Problems arise when government’s debt continues to increase but the primary balance ratio is in a negative position.This study aims to see whether the paradigm of the Ricardian fiscal regime occurs in Indonesia, which is reflected by the effect of government debt and some macroeconomic variables as explanatory variables, such as economic growth, government spending, 3-month SPN interest rates, inflation and Indonesian crude oil prices to the primary balance ratio to GDP in Indonesia in the period of 2010.Q1-2018.Q4. This research used Error Correction Model (ECM) as the method.The result shows that Ricardian fiscal regime occurs in Indonesia, reflected through government debt which has a positive and significant effect on the primary balance ratio in the long run, but does not have a significant effect in the short term. In addition, economic growth, government spending, 3-month SPN interest rates and inflation have a significant effect on the primary balance ratio in the long term.
Analisis efisiensi pengeluaran pemerintah daerah sektor kesehatan di kabupaten/kota provinsi jawa tengah tahun 2015-2017
Authors: Azmi Fauzan
Published: September 2022

High amount on health spending in Central Java province has not been offset by the achievement of good health outcomes, mostly on the mortality rate. This study assess the relative efficiency, in terms of technical costs and technical health service system, and to know improvement target in order to achieve the efficiency in the 35 districts/cities of Central Java province in 2015-2017. This study uses Data Envelopment Analysis method, using health spending as input variables, facilities and health service as intermediate output variables, health outcomes as outcome variables, variable return to scale assumption and output orientation model. The results shows that the severity of inefficiency occurred at the cost technical efficiency, with only 2 districts/cities achieving perfect efficiency, while 4 districts/cities achieve perfect system technical efficiency. The districts/cities that sustain inefficiencies are need to improve through the calculation of improvement targets by optimizing the output.
Analisis Pengaruh Produk Domestik Bruto, ICT Development Index Dan Good Governance Terhadap Indeks Pembangunan Manusia Anggota ASEAN Dan SAARC Kategori Lower-Upper Medium
Authors: Kristiawan Albertus Surya
Published: September 2022

Pencapaian pembangunan ekonomi dapat dilihat pada keberhasilan pembangunan manusia. UNDP (2008) membuat indikator Indeks Pembangunan Manusia untuk mengukur perkembangan pembangunan manusia di suatu negara. Indeks Pembangunan Manusia di Negara ASEAN dan SAARC perlu dianalisis sebab masih termasuk kategori lower-upper medium. Penelitian ini bertujuan untuk menganalisis pengaruh Produk Domestik Bruto, ICT Dvelopment Index dan variabel Worldwide Governance Indicators terhadap Indeks Pembangunan Manusia.Hasil penelitian menunjukkan variabel produk domestik bruto, ICT development Index, dan political stability and absence of violence or terrorism memiliki hubungan yang positif dan signifikan, sedangkan control of corruption memiliki hubungan yang negatif dan signifikan  terhadap indeks pembangunan manusia di negara ASEAN dan SAARC kategori lower-upper medium. variabel regulatory quality memiliki hubungan yang berbeda antara kedua organisasi regional. Pada ASEAN kategori lower-upper medium memeiliki hubungan yang positif dan signifikan sedangkan SAARC kategori lower-upper medium memiliki hubungan yang negatif dan signifikan.
ANALISIS PROFITABILITAS PADA INDUSTRI TEKSTIL DAN PRODUK TEKSTIL DI INDONESIA
Authors: Riyanto Eko
Published: September 2022

This study aims to analyze profitability in the relationship between structure and performance of the textile and textile product industry in Indonesia with an annual 2011-2014. The type of data used is secondary data obtained from the Badan Pusat Statistik (BPS) of  Indonesia. This study employs panel data regression with Fixed Effect Model (FEM). This research uses panel data to see effect of concentration ratio (CR4), internal efficiency (XEF), output value growth (Growth), and labor productivity (Prod) on profitability (PCM).The results of this research shows that the structure of textile and textile product industry in Indonesia is high-moderate oligopoly, with an average value of CR4 is 60.93 percent. The results of the regression shows internal efficiency (XEF) and labor productivity (Prod) have a positive significant effect on the profitability (PCM). While the concentration ratio (CR4) and output growth (Growth) does not have a significant effect on the profitability (PCM).
Analysis of Public Environmental Expenditure: The Case Study of Jakarta Province
Authors: Putra DIdi Prabwo
Published: September 2022

The national struggle for sustainable development influenced the sub-national governments level in composing their policy directions especially public budget policy. Nonetheless, although the environmental protection function is important, it tends to be marginalized in the national budgetary debates. This study, therefore, attempts to analyse the ‘green budget’ allocation and utilization within the Regional Medium-term Development Plan 2013 – 2017 of Jakarta Province. The methodology draws on descriptive analysis of derived data from annual provincial budget documents, and in-depth interview analysis explored potential barriers and drivers give rise to gaps in budget between the allocation and realization stage. Results show that the allocated ‘green budget’ posture of Jakarta Province was 6.1% in the five years average, significantly higher when compared to the national level at 0.8 – 1 percent. However, the realization was low with average actual spending at 47.1% of the total allocated budget. In addition, based on COFOG, the biggest function/purpose supported by the environmental affairs budget was biodiversity and land protection which are responsible for green open space provision in Jakarta Province. The interviews point to the collaboration aspect among the profound drivers to support environmental affairs policy. Meanwhile, the aspects of staff capacity, public awareness, and policy alignment are believed to be significant barriers that the government is recommended to take into consideration.
Analisa Perdagangan Bilateral Indonesia dengan Pendekatan Marshall Lerner Condition dan Fenomena J Curve
Authors: Wijaya Erric
Published: September 2022

Penelitian ini membahas mengenai analisa perdagangan bilateral Indonesia dengan menggunakan fenomena J curve dan Marshall Lerner Condition. Sampel penelitian ini menggunakan tiga negara mitra dagang terbesar Indonesia yaitu Tiongkok, Jepang, dan Singapura. Periode penelitian dari tahun 2010 kuartal 1 sampai dengan 2017 kuartal 4. Alat analisis menggunakan regresi linear berganda dengan menggunakan pendekatan kointegrasi dan Error Correction Model (ECM). Hasil penelitian menunjukkan bahwa tidak terjadi fenomena J curve dan Marshall Lerner Condition untuk perdagangan bilateral antara Indonesia dengan Tiongkok dan Indonesia dengan Jepang. Sedangkan perdagangan bilateral antara Indonesia dan Singapura terjadi fenomena J curve dan Marshall Lerner Condition. Masing-masing variabel penelitian saling terkointegrasi pada jangka panjang dan juga pada jangka pendek melalui Error Correction Model (ECM).  Pada jangka pendek perubahan nilai tukar tidak mempengaruhi perdagangan bilateral Indonesia dengan Jepang dan Singapura., tetapi berpengaruh pada perdagangan bilateral Indonesia dengan Tiongkok. Pada jangka panjang, perubahan nilai tukar berpengaruh pada perdagangan bilateral Indonesia dengan Tiongkok dan Singapura.
APAKAH KEBERADAAN BALITA MENENTUKAN PARTISIPASI KERJA PEREMPUAN KAWIN USIA SUBUR? ANALISIS SAKERNAS AGUSTUS 2019
Authors: Sulistyowati Rini
Published: September 2022

Women's labor participation has been stagnant for decades in Indonesia. Several research concluded that there was a large contribution from labor participation of married women and the presence of children in the household to the dynamics of women's labor participation. This study aims to see the relationship between the existence of children under five and the labor participation of married women aged 20-49 years. Using Sakernas August 2019, the results of descriptive statistics reveal that 40% of married women aged 20-49 years choose to not be in the laborforce. It’s mainly contributed by those who live with children under five. When entering the labor market, married women aged 20-49 years who live with toddlers are more likely to work part-time, both voluntarily and involuntarily (underemployment). Another interesting finding is that one of five married women aged 20-49 years who are not part of the labor force and who live with toddlers still have the desire to work.
ANALISIS HUBUNGAN KOMPLEMENTER DAN KOMPETISI ANTAR WILAYAH DI INDONESIA PADA ERA OTONOMI DAERAH
Authors: Nisa Khairun , Riyanto Riyanto
Published: September 2022

Interaksi horizontal antar wilayah merupakan isu penting dalam pembangunan wilayah, terutama di Indonesia. Penelitian ini bertujuan menganalisis hubungan horizontal antar wilayah yaitu hubungan komplementer dan kompetisi antar wilayah pada era otonomi daerah di Indonesia. Analisis komplementer dan kompetisi antar regional dilakukan terhadap 6 wilayah di Indonesia dengan menggunakan model Dendrinos-Sonis yang diestimasi menggunakan Ordinary Least Square (OLS) estimator dan Seemingly Unrelated Regression (SUR) estimator. Hasil analisis menunjukkan bahwa interaksi antara Wilayah Jawa dan Sumatera tetap bersifat komplementer, dan menjadi pendorong perekonomian wilayah lain, namun pengaruh wilayah Jawa mengecil dibandingkan wilayah Sumatera. Penelitian ini juga menemukan bahwa pola interaksi antar wilayah setelah era otonomi daerah cenderung menguntungkan secara ekonomi bagi wilayah Indonesia bagian Timur.
ANALISIS DAMPAK PENERBITAN OBLIGASI WAJIB KONVERSI (OWK) PT KRAKATAU STEEL TERHADAP EKONOMI PROVINSI BANTEN
Authors: Fachrizal Fachrizal
Published: September 2022

This paper tries to analyze the impact of issuance of mandatory convertible bonds by PT Karakatau Steel to Banten Province’s Economics using the 2015 Banten Province’s input-output model classification of 35 sectors. The pronouncement of the issuance of mandatory convertible bonds was made as the results of the General Meeting of Shareholders on November 24th, 2020 in Jakarta. The impact of covid-19 was also felt by national steel industries including PT Karakatu Steel, where there is a decline in demand for national steel products by up to 50%. As a result of the reduced demand, many national steel industry operations have been hit and are experiencing financial difficulties. With the issuance of OWK by PT Krakatau Steel from Government Investment in the framework of this PEN Program, it is hoped that the wheels of the national economy can rise again, especially for the province of Banten where PT Karakatu Steel is located.
Price Elasticity of Demand for Cigarette Items: Evidence from South Kalimantan Province of Indonesia
Authors: Murjani Ahmadi
Published: September 2022

Smoking can affect health conditions that can lead to many adverse impacts in a wider scope. The government of Indonesia has applied some excise tax regulations on tobacco products to control the consumption of cigarette items. With very limited studies in Indonesia about the price elasticity of demand for tobacco products, this paper aims to fill the gaps in the demand for cigarette items in Indonesia. By using a new approach to calculate the price elasticity of demands which is AIDS and QUAIDS with the ILLS approach, this paper found significant findings. It is found that only the filtered clove cigarettes that inelastic to the price increases. The government should carefully apply the excise tax regulation based on the cigarette items.