bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Primary Care Clinicians in the Management of Patients With Type 2 Diabetes and Cardiorenal Diseases
Authors: Kushner Pamela R. , Cavender Matthew A. , Mende Christian W.
Published: March 2022

Individuals with type 2 diabetes are at increased risk of both renal and cardiovascular events. The convergence of type 2 diabetes, chronic kidney disease, and cardiovascular disease, including heart failure, requires management by a multidisciplinary health care team. Primary care clinicians are likely to be the first and most frequent point of contact for individuals with type 2 diabetes who are at high risk of cardiorenal disease and therefore play a pivotal role in early diagnosis, establishment of effective treatment strategies, and coordination of care. This article presents a clinical perspective with multidisciplinary collaboration on a patient case representative of those seen in routine clinical practice. The authors assess reasons why patients may not receive evidence-based care and identify opportunities to initiate therapies that reduce cardiovascular and renal events in the primary care setting.
Trends in Timing of and Glycemia at Initiation of Second-line Type 2 Diabetes Treatment in U.S. Adults
Authors: Raghavan Sridharan , Warsavage Theodore , Liu Wenhui G. , Raffle Katherine , Josey Kevin , Saxon David R. , Phillips Lawrence S. , Caplan Liron , Reusch Jane E.B.
Published: March 2022

OBJECTIVE

Therapeutic inertia threatens the potential long-term benefits of achieving early glycemic control after type 2 diabetes diagnosis. We evaluated temporal trends in second-line diabetes medication initiation among individuals initially treated with metformin.

RESEARCH DESIGN AND METHODS

We included data from 199,042 adults with type 2 diabetes in the U.S. Department of Veterans Affairs health care system initially treated with metformin monotherapy from 2005 to 2013. We used multivariable Cox proportional hazards and linear regression to estimate associations of year of metformin monotherapy initiation with time to second-line diabetes treatment over 5 years of follow-up (primary outcome) and with hemoglobin A1c (HbA1c) at the time of second-line diabetes treatment initiation (secondary outcome).

RESULTS

The cumulative 5-year incidence of second-line medication initiation declined from 47% among metformin initiators in 2005 to 36% in 2013 counterparts (P < 0.0001) despite a gradual increase in mean HbA1c at the end of follow-up (from 6.94 ± 1.28% to 7.09 ± 1.42%, Ptrend < 0.0001). In comparisons with metformin monotherapy initiators in 2005, adjusted hazard ratios for 5-year initiation of second-line diabetes treatment ranged from 0.90 (95% CI 0.87, 0.92) for 2006 metformin initiators to 0.68 (0.66, 0.70) for 2013 counterparts. Among those receiving second-line treatment within 5 years of metformin initiation, HbA1c at second-line medication initiation increased from 7.74 ± 1.66% in 2005 metformin initiators to 8.55 ± 1.92% in 2013 counterparts (Ptrend < 0.0001).

CONCLUSIONS

We observed progressive delays in diabetes treatment intensification consistent with therapeutic inertia. Process-of-care interventions early in the diabetes disease course may be needed to reverse adverse temporal trends in diabetes care.
Family ties of the Kolyubakins, the Linevs, and the Dolgorukovs, the landowners of Ustyuzhna Uyezd, in the 17th–19th centuries
Authors: Marov Mikhail N.
Published: March 2022

The article is devoted to the consideration of regularities in the process of formation of regional landowning families in the territory of Ustyuzhna Uyezd in the 17th–19th centuries. The study takes into account the mutual ties between the clans, using the example of the landowning families of the Kolyubakins, the Linevs, and the Dolgorukovs. It was revealed from which administrative-territorial formations (pyatinas of the Novgorod Lands) and for what reason the landowning families of Kolyubakins, Dolgorukovs, and Linevs were resettled to Ustyuzhna-Zhelezopolskaya Uyezd at the beginning of the 17th century. The facts of relationships and family ties between the families of landowners under consideration are identified and the reasons for the emergence of these ties are analyzed on the basis of the analysis of a number of documents from the fonds of the Heralds office (F. 286), Pomestnyi Prikaz (F. 1209), and the Ustyuzhna Voivodeship Chancellery (F. 596) in the Russian State Archive of Ancient Acts, which are introduced into scientific circulation for the first time, as well as of the results of the research on the history of the ancient Kolyubakin family, conducted by the author. It is shown that the family ties of the Kolyubakins, Linevs and Dolgorukovs led to the redistribution of landed property between these clans due to its transfer as a dowry or inheritance by collateral by nephews and grand-nephews from maternal lineage. In the course of the research, the Ustyuzhna branch of the noble family of Dolgorukov is reconstructed, including five generations of descendants, and covering the period from the end of the 16th century to the second half of the 18th century. The development of the family clans of the Dolgorukovs, Linevs, and Kolyubakins in Ustyuzhna Uyezd in the period between the 17th and the 19th centuries is analyzed. It is esbalished that at the end of the 19th century, of the three families to which this article is devoted, only the Kolyubakins still remained among the prosperous landowners of the uyezd. It is noted that the village of Rastoropovo in Ustyuzhna Uyezd, which survived to this day, was the geographical center of the events described in the article. The analysis made it possible to illustrate with specific examples and in detail a number of previously identified patterns in the formation of land ownership in Ustyuzhna Uyezd.
Weighting Comparative Analysis Using Fuzzy Logic and Rank Order Centroid (ROC) in the Simple Additive Weighting (SAW) Method
Authors: Ghazali Alfin , Sihombing Poltak , Zarlis Muhammad
Published: March 2022

The Covid-19 outbreak has changed the learning system in Indonesia into distance learning, better known as online learning. In determining student learning outcomes on student learning satisfaction with distance learning during the Covid-19 pandemic, a study was carried out using the Simple Additive Weighting (SAW) method. This study aims to determine student learning outcomes during the Covid-19 pandemic. The type of research used in this research is applied research, in which this research is directed to obtain information that can be used to solve problems. The method used is Simple Additive Weighting (SAW) by comparing the results of the decision of the SAW method between the weighting based on the Fuzzy Logic method and the weighting based on the ROC method. The subjects involved in this study were 36 students of Vocational High School (SMK). Data collection in the study was carried out using direct observation, interviews, and questionnaires. The criteria contained in the questionnaire are factors that affect the process of student learning outcomes on learning satisfaction during the Covid-19 pandemic. The criteria used are device ownership, accessibility, ease of obtaining materials, method accuracy, monitoring ability, interactivity, and independent learning. From the seven criteria, the priority scale is determined. The results showed that the analysis of the search for weight scores using the Simple Additive Weighting (SAW) method using Fuzzy Logic and Simple Additive Weighting (SAW) using the Rank Order Centroid (ROC) method resulted in different sub-criteria weighting scores, so it can be said that the combination of SAW- ROC provides a more accurate and more selective selection of the number of students.
Presentation Content Structuredness: How does It Affect the Audience?
Authors: Suwartono Tono , Furqon Miftahul
Published: March 2022

Masih banyak pendidik yang belum dapat memanfaatkan slide PowerPoint dengan baik. Guru biasanya membuat slide yang penuh dengan teks, kecuali yang dimaksudkan untuk menunjukkan contoh teks, yang tidak akan mengesankan penonton. Penelitian ini bertujuan untuk menguji apakah struktur konten presentasi berpengaruh signifikan terhadap keterlibatan audiens. Pengalaman profesional menunjukkan bahwa banyak orang membuat presentasi gagal dalam misi mereka karena mereka memiliki kendala dengan masalah ini. Studi ini menggunakan salah satu Desain Pra-Eksperimental dengan melibatkan empat puluh delapan mahasiswa sarjana yang bergabung dengan Forum Akademik yang diadakan oleh departemen. Pengumpulan data dilakukan dengan menggunakan tes dan angket. Analisis data menggunakan statistik deskriptif dan uji-t. Hasil penelitian menunjukkan bahwa struktur presentasi memiliki dampak yang signifikan terhadap penguasaan audiens terhadap materi yang disajikan. Selain itu, presentasi mendapat tanggapan positif dari para hadirin terutama karena beberapa alasan, yaitu: materi yang relevan dan cara penyampaian yang disukai, presentasi yang sudah baik dan penyelenggaraan acara yang memuaskan, dan porsi pengalaman yang sesuai, kemungkinan besar disebabkan oleh upaya sengaja presenter untuk menyusun materi agar audiens tetap terlibat selama presentasi.
Comparing Students' Learning Result on Reading Comprehension Through SQ3R and Reciprocal
Authors: Sunarti Sunarti , Chairunnisa Nadhifah Murliana , Irwan Muhammad , Rizal Akhmad
Published: March 2022

Banyak siswa yang mengalami kesulitan belajar bahasa Inggris. Siswa merasa bahwa bahasa Inggris adalah mata pelajaran yang rumit, sehingga berdampak pada kemampuan bahasa Inggris siswa yang rendah. Penelitian ini bertujuan untuk menganalisis pemahaman membaca siswa yang dibelajarkan menggunakan SQ3R, pemahaman membaca siswa yang dibelajarkan menggunakan Reciprocal, dan menganalisis teknik yang lebih efektif antara SQ3R dan Reciprocal dalam pemahaman membaca siswa. Penelitian ini menggunakan desain pretest-posttest control group design. Populasi dalam penelitian ini adalah siswa kelas sepuluh berjumlah 35 orang siswa. Penelitian ini menggunakan sampel kelas yang terpilih dengan menggunakan simple random sampling. Prosedur analisis data menggunakan statistik deskriptif dan inferensial. Hasil penelitian menunjukkan bahwa kedua metode tersebut sama-sama efektif dalam mengajar pemahaman bacaan. Hasil uji T-test pretest-posttest paired sample test terdapat perbedaan nilai siswa yang signifikan antara sebelum dan sesudah diberikan perlakuan, baik pada kelas Reciprocal, maupun kelas SQ3R. Hal ini dibuktikan dengan hasil uji-t (independent sample test), diperoleh hasil t-hitung 0,242 < t-tabel pada taraf signifikan 5% (2,042) atau 1% (2,75). Hasil analisis menunjukkan bahwa 2.042>0.242<2.75. Hal ini membuktikan bahwa tidak ada perbedaan yang signifikan antara kelas yang dibelajarkan menggunakan Reciprocal dan SQ3R. Pengajaran Reciprocal sama baiknya dengan metode SQ3R dalam meningkatkan pemahaman membaca siswa. Dapat disimpulkan bahwa Reciprocal Teaching sama efektifnya dengan metode SQ3R dalam pembelajaran membaca pemahaman siswa.
Peningkatan Hasil Belajar Siswa melalui Problem Based Learning (PBL)
Authors: Isma Teguh Wijaksana , Putra Rido , Wicaksana Tiara Indah , Tasrif Elfi , Huda Asrul
Published: March 2022

Proses pembelajaran masih belum maksimal karena model pembelajaran yang digunakan masih konvesional. Peserta didik kurang diberi kesempatan menyusun pengetahuannya sendiri dalam proses pembelajaran. Hal ini berdampak kepada minat peserta didik dalam proses pembelajaran. Penelitian yang dilakukan bertujuan untuk menganalisis perbedaan hasil belajar peserta didik ketika menggunakan model pembelajaran Problem Based Learning.  Jenis penelitian yang digunakan adalah meta analisis dari penelitian yang dilakukan sebelumnya. Pengumpulan data dilakukan dengan cara menelusuri jurnal di internet. Dari penelusuran didapatkan 22 jurnal yang sesuai dengan kategori yang ingin diteliti yang terdiri atas 4 jurnal berhubungan dengan Sekolah Dasar, 5 jurnal berhubungan dengan Sekolah Menegah Pertama, 9 jurnal berhubungan dengan Sekolah Menegah Atas, dan 4 jurnal berhubungan dengan Sekolah Menengah Kejuruan. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Berdasarkan hasil analisis 22 jurnal tersebut, diketahui  bahwa terjadi kenaikan hasil belajar siswa ketika menggunakan metode tersebut. Kenaikan hasil belajar terbesar terjadi pada tingkatan Sekolah Menegah Atas. Sedangkan untuk kenaikan hasil belajar terkecil yaitu pada tingkatan Sekolah Menegah Kejuruan (SMK). Penerapan model Problem Based Learning sebagai alternatif kegiatan belajar yang menyenangkan.
Strategi Belajar dalam Mencapai Hasil Belajar IPA pada Siswa Sekolah Menengah Pertama
Authors: Widyantari Ni Kadek Sri , Suardana I. N. , Karyasa I.W.
Published: March 2022

Masih banyak siswa yang memperoleh nilai IPA di bawah Kriteria Ketuntasan Minimal karena motivasi dan minat siswa yang kurang. Tujuan penelitian dilakukan untuk menganalisis strategi belajar siswa kelas VIII SMP Negeri 1 Tegallalang dalam mencapai hasil belajar pada mata pelajaran IPA. Penelitian yang dilakukan adalah penelitian kualitatif dengan jenis pendekatan eksploratif. Subjek penelitian yang terlibat yaitu siswa dan guru IPA sejumlah 11 orang. Metode pengumpulan data yang digunakan adalah observasi dan wawancara. Teknik analisis data penelitian meliputi reduksi data, paparan data, dan verifikasi data. Hasil penelitian menunjukkan bahwa siswa memperoleh kategori hasil belajar tinggi menggunakan strategi kognitif, metakognitif, dan sikap sosial. Hasil belajar yag dimaksud meliputi membaca materi berulang-ulang, menggarisbawahi pokok penting materi, mencatat dan merangkum isi materi, merencanakan aktivitas belajar, merencanakan sumber belajar, memantau proses dan hasil belajar, membandingkan hasil belajar dengan target yang ditetapkan, menjawab dan menyampaikan pertanyaan, serta sikap tenang saat menghadapi tes. Siswa dengan kategori kemampuan belajar sedang, menggunakan strategi belajar kognitif dan metakognitif dalam mencapai hasil belajar IPA di antaranya membaca berulang-ulang materi, mencatat dan merangkum isi materi pelajaran, membuat kerangka garis-garis besar materi serta merencanakan  sumber-sumber belajar. Siswa dengan kategori hasil belajar rendah memakai strategi belajar kognitif dalam mencapai hasil belajar IPA yaitu membaca materi berulang-ulang sampai mengerti. Faktor-faktor yang berpengaruh terhadap strategi belajar siswa yaitu karakteristik materi pembelajaran, motivasi belajar siswa, minat belajar siswa, serta intelegensi siswa.
Meningkatkan Kemampuan Pemecahan Masalah Matematika Ditinjau dari Kemampuan Berpikir Kritis Melalui Pendekatan Saintifik Berbasis Pembelajaran Treffinger
Authors: Hermayuni Ni Made Tri Dhana , Lasmawan I Wayan , Gunamantha Made
Published: March 2022

Kemampuan pemecahan masalah siswa pada mata pelajaran matematika rendah. Rendahnya kemampuan pemecahan masalah dipengaruhi oleh beberapa faktor, seperti rendahnya motivasi belajar siswa dan metode belajar yang kurang tepat. Penelitian ini bertujuan untuk menganalisis pengaruh pendekatan saintifik berbasis pembelajaran treffinger terhadap kemampuan pemecahan masalah matematika ditinjau dari kemampuan berpikir kritis siswa SD kelas IV. Penelitian yang dilakukan ini merupakan penelitian eksperimen. Rancangan yang digunakan dalam penelitian ini adalah factorial design (rancangan faktorial) 2x2 dan desain penelitian Post-test only control group design. Populasi penelitian ini adalah seluruh siswa kelas IV sekolah dasar yang berjumlah 157 siswa. Metode yang digunakan untuk mengumpulkan data yaitu observasi, wawancara, dan tes. Instrumen yang digunakan untuk mengumpulkan data yaitu lembar soal. Teknik yang digunakan untuk menganalis data yaitu analisis deskriptif kualitatif, kuantitatif, dan statistic inferensial. Hasil penelitian menunjukkan bahwa  terdapat perbedaan kemampuan pemecahan masalah matematika antara siswa yang mengikuti pembelajaran dengan pendekatan saintifik berbasis pembelajaran treffinger dan siswa yang mengikuti pembelajaran konvensional.  Siswa yang mengikuti pembelajaran dengan pendekatan saintifik berbasis pembelajaran treffinger lebih baik dibandingkan dengan siswa yang mengikuti pembelajaran konvensional. Hal ini ditunjukkan dengan rata-rata kemampuan pemecahan masalah matematika siswa yang mengikuti pembelajaran dengan pendekatan saintifik berbasis pembelajaran treffinger lebih tinggi daripada kemampuan pemecahan masalah matematika siswa yang mengikuti pembelajaran dengan pembelajaran konvensional. Disimpulkan bahwa terdapat pengaruh pendekatan saintifik berbasis pembelajaran treffinger terhadap kemampuan pemecahan masalah siswa.
Makam Chabib Umar Bin Yusuf Al-Magribi Di Desa Candikuning, Bedugul: Sejarah, Dampak Sosial Ekonomi Dan Potensinya Sebagai Sumber Belajar Sejarah Di SMA
Authors: . NUR MINAH , . Dr. Drs. I Made Pageh, M.Hum. , . Ketut Sedana Arta, S.Pd., M.Pd.
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui (1) Sejarah pendirian makam Chabib Umar Bin Yusuf Al- Magribi di Desa Candikuning, (2) Dampak sosial ekonomi bagi masyarakat Desa Candikuning, (3) Potensi makam Chabib Umar Bin Yusuf Al- Magribi di Desa Candikuning, Bedugul dapat digunakan sebagai sumber belajar sejarah di SMA. Penelitian ini merupakan penelitian sejarah, sehingga langkah-langkah yang dilakukan adalah (1) Heuristik; (2) Kritik Sumber; (3) Interpretasi; (4) Historiografi. Hasil penelitian ini menunjukkan bahwa, (1) Sejarah pendirian makam Chabib Umar Bin Yusuf Al- Magribi dengan ditemukannya lokasi makam yang terletak di atas bukit bedugul Desa Candikuning pada tahun 1940-an yang disinyalir merupakan makam seorang tokoh penyebar agama Islam yang berasal dari Timur Tengah. (2) Dampak sosial ekonomi dari Makam Chabib Umar Bin Yusuf Al- Magribi bagi masyarakat di Desa Candikuning, Bedugul adalah dampak mengenai mata pencaharian masyarakat sekitar makam, pendapatan masyarakat sekitar makam, serta interaksi sosial yang terjadi di dalam masyarakat. (3) Makam Chabib Umar Bin Yusuf Al- Magribi mengandung nilai historis sebagai salah satu tokoh penyebar agama Islam di Bali dan merupakan salah satu wali pitu yang dapat dijadikan sebagai sumber belajar sejarah lokal di SMA. Kata Kunci : Sejarah, Dampak Sosial Ekonomi, dan Sebagai Sumber Belajar Sejarah The purpose of this study was to find out (1) History of the chabib Umar Bin Yusuf Al- Magribi tomb in the village of Candikuning, (2) Socio economic impact for the community in the village of Candikuning, (3) Potential of the tomb of Chabib Umar Bin Yusuf Al- Magribi in the village of Candikuning, Bedugul can be used as a source of historical learning in high school. This research is a historical research, so the steps taken are (1) Heuristics; (2) Source Criticism; (3) Interpretation; (4) Historiography. The results of this study indicate that, (1) The history of the establlishment of the Chabib Umar Bin Yusuf Al- Magribi tomb with the discovery of the location of the tomb located on the hill of the village of Candikuning Bedugul in the 1940s which was allegedly the tomb of a prominent Muslim propagator from the Middle East. (2) The socio economic impact of the Chabib Umar Bin Yusuf Al- Magribi tomb for the community in the village of Candikuning, Bedugul is the impact on the livelihoods of the people around the tomb, as well as the social interactions that occur within the community. (3) The tomb of Chabib Umar Bin Yusuf Al- Magribi containts historical value as one of the leaders of the spread of Islam in Bali and is one of the guardians who can be used as a source of learning local history in high school.keyword : History, Socio-Economic impact, and as a Source of Learning History
Identifikasi Peninggalan Tantrayana di Pura Kebo Edan di Desa Pejeng, Gianyar, Bali dan Potensinya Sebagai Sumber Belajar Sejarah di SMA
Authors: Yoga I Komang Krisna
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui: (1) Sejarah Pura Kebo Edan (2) Peninggalan dari Pura Kebo Edan (3) Potensi Pura Kebo Edan sebagai sumber belajar sejarah di SMA. Penelitian ini dilakukan dengan menggunakan metode kualitatif dengan langkah-langkah:(1) penentuan lokasi penelitain (2) penentuan informan (3) Pengumpulan data (4) tahap validasi data menggunakan teknik triangulasi data. Temuan dari penelitian ini adalah: (1) Sejarah Pura Kebo Edan tidak bisa dilepaskan dari raja Kertanegara yang menganut aliran Tantrayana dari kerajaan Singosari yang pada saat itu berhasil menaklukkan Bali, kemudian mengutus seorang Patih yang beranama Kebo Parud ke Bali sebagai perwakilan dari kerajaan Singosari. Nama Pura Kebo Edan diambil dari nama sepasang arca utama yang berbentuk kerbau yang terdapat di pura tersebut.. (2) Peninggalan-peninggalan dari Pura Kebo Edan yang memiliki corak aliran Tantrayana yaitu Arca Siwa Bhairawa, Arca Raksasa, sepasang Arca Kerbau, Arca Bhairawa, Arca Ganesha, Arca Perwujudan, Fragmen Lapik, dan Fragmen Bangunan. (3) Potensi yang dimiliki Pura Kebo Edan sebagai sumber belajar sejarah di SMA yaitu: (1) Aspek Historis (2) Aspek Peninggalan (3) Aspek Aktivitas Budaya.
Antropoceno é uma outra Coisa/ Outra coisa
Authors: Messias Adriano
Published: March 2022

Este texto aborda o Antropoceno a partir de uma visão semiótico-psicanalítica, que busca o que está além de estatísticas e números. O autor se alia ações micro a ações macro a fim de se dar conta do incomensurável impacto negativo do humano na Terra. Trata-se de uma abordagem que se volta tanto ao “subterrâneo da cultura” quanto aos “subterrâneos do ser”, já que os problemas climáticos, por exemplo, são apenas parte do que chamo de “antropoviolações”. Única espécie falante do planeta no sentido lacaniano, somos atravessados pelas pulsões, as quais nos conduziram a um “ponto de não retorno”: não é mais possível resolver ou atenuar muitas das alterações antropocêntricas no mundo. No cerne deste imbróglio, um ponto frágil: a responsabilização de cada um. Neste sentido, há algo no Antropoceno que diz respeito a um não querer saber – provavelmente ligado à finitude das coisas e dos seres.
Apraxia de fala Infantil em quadros com comorbidades
Authors: De Oliveira Aline Mara , Pires Amanda Del Nero Alves , Cruz Greicyhelen Santos da , Gurgel Léia Gonçalves , Deschamps Luciane Mari
Published: March 2022

Introdução: A apraxia de fala na infância (AFI) pode resultar de comprometimentos neurológicos, estar associada a distúrbios neuro-comportamentais complexos ou ter entidade nosológica desconhecida. Objetivo: Relacionar as comorbidades associadas à Apraxia de Fala Infantil (AFI) e suas manifestações clínicas. Método: A presente revisão sistemática foi conduzida conforme recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A busca por artigos científicos foi realizada na base de dados Medline (via Pubmed), LILACS, Scopus e SciELO. Os termos de busca utilizados foram: Comorbidity, Apraxias, Childhood apraxia of speech, Dyspraxia, Speech, e seus entretermos, em inglês. Foram incluídos todos estudos cujos sujeitos apresentavam alguma síndrome e/ou transtorno diagnosticado e apraxia de fala. Inicialmente, títulos e resumos dos artigos foram analisados. Três revisores independentes avaliaram os artigos completos e realizaram suas seleções de acordo com os critérios de elegibilidade. Em todas as etapas, as discordâncias foram resolvidas por consenso. O dado principal coletado foi quanto à ocorrência de comorbidades em sujeitos com AFI. Resultados: As comorbidades mais presentes associadas à Apraxia de Fala Infantil foram Transtorno do Espectro Autista, Epilepsia Rolândica e Síndrome de Down. As causas genéticas vêm como preditor da associação entre Apraxia de Fala Infantil e estas comorbidades. Conclusão: Como a AFI é um distúrbio de manifestação heterogênea, pode se apresentar em conjunto com diversas comorbidades, o que gera um diagnóstico tardio, para AFI e o distúrbio secundário. Ainda, dificultando o processo de avaliação e intervenção precoce, comprometendo o desenvolvimento de habilidades importantes de fala.
HEREDITARY MOTOSENSORY NEUROPATHY TYPE I (CHARCOT–MARIE–TOOTH DISEASE, TYPE I A): A CLINICAL CASE OF AN EARLY ONSET OF THE DISEASE
Authors:   Krasnoyarsk Krai Regional Clinical Center for Maternal and Child Welfare, Krasnoyarsk, Krasnoyarsk Krai, Russia, Demyanova I.M. , Vshivkov D.A. ,   Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Krasnoyarsk Krai, Russia, Taranushenko T.E. ,   Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Krasnoyarsk Krai, Russia, Kustova T.V. ,   Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Krasnoyarsk Krai, Russia, Konkov N.A. ,   Krasnoyarsk Krai Regional Clinical Center for Maternal and Child Welfare, Krasnoyarsk, Krasnoyarsk Krai, Russia, Sharoglazov M.F. ,   Krasnoyarsk Krai Regional Interdistrict Children’s Clinical Hospital No. 1, Krasnoyarsk, Krasnoyarsk Krai, Russia
Published: March 2022

Hereditary motor sensory neuropathies (HMSNs) are the most common degenerative disorders of the peripheral nervous system in children. In this pathology, degenerative lesions of the myelin sheaths and/or axons lead predominantly to distal paralytic amyotrophy, affecting mainly the lower extremities, and are accompanied by areflexia. A clinical case of HMSN type I (Charcot–Marie–Tooth disease, type I A) with an early (up to 1 year) onset of the disease is described. The clinical features of this observation are a very early onset of the disease with a debut before the age of 1 year, the absence of pronounced amyotrophies and characteristic deformities of the feet («hollow foot»). To diagnose this genetic disease, a molecular genetic study was carried out. As a result of DNA sequencing (panel «Neuromuscular diseases»), data were obtained on the presence of a duplication of a segment of chromosome 17 with approximate boundaries of 14005424 – 15162520 bp, covering sections of several genes, including the PMP22 gene. Chromosomal micromatrix targeted analysis revealed a microduplication of the short arm (p) region of chromosome 17 from position 14076430 to position 15441811, covering the 17p12 region. The duplication zone also includes the PMP22 gene, the duplication of which is the cause of Charcot–Marie–Tooth disease, type 1A. At this time, there are no methods of pathogenetic therapy for HMSN, therefore, early diagnosis is of great practical importance, which makes it possible to start rehabilitation measures and prevent the disease in burdened families in a timely manner, based on medical genetic counseling and prenatal DNA diagnostics.
NOD2 GENE POLYMORPHISM IN CHILDREN WITH RECURRENT RESPIRATORY INFECTIONS
Authors:   Medical College with the Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia, Kazumian M.A. , Kozlov I.G. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Vasilenok A.V. ,   Medical College with the Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia,   Pirogov Russian National Research Medical University, Moscow, Russia, Teplyakova E.D. ,   Rostov State Medical University, Rostov-on-Don, Russia, Shkurat T.P. ,   "Nauka" ("Science") Medical Center, Rostov-on-Don, Russia
Published: March 2022

The highest incidence rate is recorded among children with recurrent respiratory infections (RRI). It has been shown that changes in the NOD2 gene, which encodes the innate immunity receptor, can be factors in susceptibility to viral pathogens. The aim of the study was to analyze the polymorphism of the NOD2 gene in children with RRI. Materials and methods of research: a single-center cohort observational retrospective cohort study was carried out. The study was conducted among children aged 1–18 years. The study included 500 patients with an annual number of proven RRI episodes of at least 6 in the last year in relation to the date of the start of the study (10.01.2017–12.31.2019; mean age 15±2.7 years, male sex 51.2%) and 100 conditionally healthy children included in the control group (mean age 12±2.6, male sex 48.0%). Leu1007fsinsC, Cly908Arg, and Arg702Trp, polymorphic variants of the NOD2 gene were determined by the allele-specific polymerase chain reaction (PCR). Results: it was found that in children with the insertion of the nucleotide «C» (Leu1007fsinsC), the chance of developing RRI is higher compared to other NOD2 gene polymorphism. Age-specific features of the occurrence of the Leu1007fsinsC polymorphism of the NOD2 gene in patients with the N/insC genotype were revealed. Conclusion: there were no statistically significant differences in the frequency of occurrence of polymorphic variants Arg702Trp (2104 С>T) и Gly908Arg (2722G>C) of the NOD2 gene in children with RRI compared with the control group. The predisposition of children to RRI may be associated with a Leu1007fsinsC polymorphisms of the NOD2 gene. These data require further study and may be useful for the development of new approaches to personalized RRI therapy, since the use of pattern recognition receptors (PRRs) agonists and drugs that modulate PRR-mediated signaling pathways is the most rational therapeutically effective approach for children with RRI.
IMMUNE DYSREGULATION SYNDROME WITH CTLA4 HAPLOINSUFFICIENCY: CLINICAL AND IMMUNOLOGICAL PHENOTYPE AND THERAPEUTIC APPROACHES
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Bogdanova D.V. , Rodina Yu.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shcherbina A.Yu. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: March 2022

CTLA4 haploinsufficiency with autoimmune infiltration (CHAI – CTLA4 haploinsufficiency with autoimmune infiltration) is a rare primary immunodeficiency diseases (PIDDs) that belongs to the group of T-regopathy or PIDDs with immune dysregulation. Monoallelic mutations in the CTLA4 gene cause haploinsufficiency of the homonymous protein and lead to multiple autoimmune complications, such as lymphoproliferation, immune cytopenias, lymphocytic interstitial pneumonia (LIP), inflammatory diseases of the gut, CNS damage, etc., combined with increased susceptibility to infections. Algorithms for the treatment of patients with CHAI have not yet been developed, however, there are promising therapeutic options for targeted therapy with a biologically modified CTLA4 abatacept drug. Hematopoietic stem cell transplantation is indicated for patients with a severe course of the disease, however, in order to draw conclusions about the efficacy and safety of this method of treatment, long period observations and large groups of patients are required.
FUNGAL SENSITIZATION IN PATIENTS WITH HAY FEVER
Authors:   Perm State Medical University named after Academician E.A. Wagner, Perm, Perm Krai, Russia, Minaeva N.V. , Islamova R.I. ,   Perm State Medical University named after Academician E.A. Wagner, Perm, Perm Krai, Russia, Plakhina K.V. ,   Perm State Medical University named after Academician E.A. Wagner, Perm, Perm Krai, Russia
Published: March 2022

Fungal sensitization makes a significant contribution to the development of allergopathology. Literature reviews, based on domestic and foreign literature data, present general characteristics of mold allergens. It reflects features and problems of diagnosis of mold allergy. The necessity of aeropalynological monitoring of mold allergens is considered in connection with the combined influence of pollen and mold on the development of clinical manifestations of hay fever.
Eco-Critical Approach of Amitav Ghosh and Kamala Markandaya
Authors: Kukade Mr. Vinod Manoharrao
Published: March 2022

This paper deals with the eco-critical approach of Amitav Ghosh and Kamala Markandaya in their select novels. The focus is on finding the approach of Amitav Ghosh and Kamala Markandaya towards continuous devastation of the natural atmosphere and deterioration of the relationship between man and nature. Both the writers are called great environmentalists who criticize the inhuman behaviour and ill-treatment of the human beings towards the aspects of nature. The healthy atmosphere of the universe has been getting destroyed since long back by different illogical and unethical attitude of the people towards one another and towards the nature. Both the writers have highlighted in their novels the imperialistic tendency of the colonizers and growing modernization which devastated the healthy environment and broke the amicable relationship between man and nature. This paper studies the Sea of Poppies (2008) of Amitav Ghosh and The Coffer Dams (1969) of Kamala Markandaya. An analytical method is used to go through the study.
Quest for Identity: a look into Arundhati Roy’s God of Small Things and Shashi Deshpande’s Roots and Shadows
Authors: P.S. Rahana
Published: March 2022

The paper discusses the identity crisis faced by the women living in different strata of the society. At times, women are pushed out of the main circle and are forced to remain unrepresented and unheard. Though literature has discussed such issues from time to time, it’s still a matter of concern. Here, the paper presents the identity crisis faced by the women in Arundathi Roy’s God of Small Things and Shashi Deshpande’s Roots and Shadows and the struggle that they had undergone.
The Online Student Portfolio Implementation at the Faculty of Civil Engineering, Universiti Teknologi MARA, Pulau Pinang Malaysia
Authors: Ismail Ruqayyah , Petrus Clotilda , Marajan Caroline , Baharom Bahardin , Zakwan Fariz Aswan Ahmad
Published: March 2022

A student learning portfolio is a documentation of student work that exhibits a student's effort, learning progress, achievements, and competencies gained during a course or time in university. However, compiling a hardcopy student learning portfolio requires excessive physical resources and space. Therefore, an innovative, creative and economical solution is needed for quality student service. Hence the Faculty of Civil Engineering, Universiti Teknologi MARA, Pulau Pinang, has developed an initiative to implement an online student learning portfolio using the Google Sites online platform. This paper has two main objectives. Firstly, to describe the documentation processes of the online student portfolio implementation, which comprises the students' learning reflection, the cumulative Program Outcomes, (PO) attainment, and the progressive learning performance. Secondly, to evaluate the effectiveness of the implementation of the student learning portfolio using an online platform. 863 students participated and successfully produced the online learning portfolio. The output and feedback received from the participants show that the implementation of the online student portfolio is highly beneficial and effective for both the students and the Faculty management, especially during a pandemic like COVID-19, where an economical solution is required, and the availability of documentation online can be accessed remotely.
Aesthetics of Hui Folk Dance as Audience Service to Leverage Audience Satisfaction
Authors: Wu Chunyang , Bakar Muhammad Fauzan Abu , Voon Boo Ho
Published: March 2022

Hui folk dance has its unique charm as an indispensable part of Chinese folk dance. It reflects the customs and cultural characteristics of the Hui nationality. This article explores the historical formation of Hui folk dance, analyses its formation process in different periods of history, analyses the culture, the body vocabulary of the folk dance, the music, the rhythm of the dance, the influence on the folk dance, and the expression of aesthetic consciousness. Folk dances of the Hui nationality originate from the folk, and they also show their unique living habits, combining dance with the details of life to outline their unique dance posture. Hui folk dance expresses the value of aesthetic emotions, aesthetic knowledge, and aesthetic ideals of dance through historical portraits, national spirits, and traditional canons. The formation, aesthetic consciousness, and aesthetic characteristics of Hui folk dance were analysed to better understand the history and culture of Hui folk dance, learn it, inherit it, promote it, and enrich it for sustainability. Dance aesthetics as part of audience service. The audience will be aesthetically satisfied and this will affect their behavioural intentions.
Message from the Chief Editor: Service Excellence Attitudes Amidst COVID-19 Pandemic
Authors: Voon Boo Ho
Published: March 2022

The deadly coronavirus disease which started in the year 2019 (COVID-19, as named by the World Health Organization) is a grave threat to mankind. This COVID-19 pandemic has caused the loss of many lives worldwide. Henceforth, this omni-present and dangerous virus need to be curbed soonest possible and the entire world needs to do its best with love and care to contain the pandemic. As being said, all stakeholders at different levels need to join hands and work together consistently and continuously to achieve service excellence for sustainability.
Complete Placenta Previa at 39 Weeks Gestation on Multiparous and Two Times History of Caesarean Section with Complication of Post Partum Haemorrhage and Hypovolemic Shock
Authors:   Rumkit Tk II Dr R Hardjanto Balikpapan, Roni Reski Wulandari , Pujojati Ferri Waluyo Wiwoho
Published: March 2022

Penyebab Angka Kematian Ibu (AKI) yang utama ialah perdarahan. Di Indonesia, menurut Survei Demografi dan Kesehatan Indonesia (SDKI) tahun 2012, AKI di Indonesia masih tinggi sebesar 359 per 100.000 kelahiran hidup. Berdasarkan data tahun 2010-2013 penyebab kematian terbesar kematian ibu ialah perdarahan. Plasenta previa merupakan salah satu penyebab perdarahan yang tersering terjadi pada ibu hamil. Tujuan dari penulisan laporan kasus ini adalah memahami komplikasi dari plasenta previa yaitu perdarahan pasca salin dan bagaimana tatalaksana kasus tersebut. Kami melaporkan kasus mengenai seorang wanita 31 tahun dengan plasenta previa totalis pada usia kehamilan 39 minggu. Pasien memiliki riwayat dua kali seksio sesaria sebelumnya. Didapatkan perdarahan pasca salin saat dilakukan seksio sesaria disertai syok hipovolemik. Komplikasi yang disebabkan oleh letak plasenta yang rendah adalah perdarahan pasca salin yang terjadi selama pembedahan. Perkiraan jumlah kehilangan darah sebanyak 2500 cc, dan didapatkan hemoglobin 1,8 g%. Kondisi hemodinamik tidak stabil dengan tekanan darah 80/50 mmHg, dan kesadaran pasien mulai menurun. Kondisi pasien membaik 3 hari pasca operasi dengan monitoring ketat di Unit Perawatan Intensif (ICU). Total Placenta Previa with Complication of Post Partum Haemorrhage at 39 Weeks Gestation on Multiparous Abstract The main cause of maternal mortality (MMR) is bleeding. In Indonesia, according to the 2012 Indonesian Demographic and Health Survey (IDHS), the maternal mortality rate in Indonesia is still high at 359 per 100,000 live births. Based on data in 2010-2013 the biggest cause of maternal death is bleeding. Placenta previa is one of the most common causes of bleeding in pregnant women. The purpose of writing this case report is to understand the complication of placenta previa, post partum hemorrhage, and how to manage this case. We report the case of a 31-year-old woman with total placenta previa at 39 weeks' gestation with a history of previous cesarean section two times presenting with postpartum haemorrhage during cesarean section. The patient was found with hypovolemic shock. The estimated blood loss of the patient was 2500 cc and the patient's hemoglobin was 1.8 g%. The patient's blood pressure dropped to 80/50 mmHg, and the patient's consciousness was disturbed. The patient's condition improved 3 days after surgery and close monitoring in the Intensive Care Unit (ICU). Key word : Total Placenta Previa, Post Partum Haemorrhage.
Genotip Virus Human Pappiloma Tipe Risiko Rendah Pada Wanita Pekerja Seks Komersial di Kota Makassar
Authors:   Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Hasanuddin, Montolalu Yurike Adeline Chandra , Susiawaty Susiawaty , Arifuddin Sharvianty
Published: March 2022

Tujuan: Mengetahui genotip HPV risiko rendah melalui pemeriksaan DNA HPV dan mencari hubungan faktor risiko terhadap angka kejadian infeksi HPV pada PSK diMakassar Metode: Jenis penelitian ini adalah potong lintang dan terlaksana pada bulan Agustus 2019. Populasi penelitian adalah wanita PSK usia reproduktif dengan total 80 sampel. Hasil: Pemeriksaan genotip HPV menunjukkan tipe HPV risiko rendah didominasi oleh tipe 43 dan 44 serta riwayat coitarche berpengaruh terhadap angka kejadian Infeksi HPV di Makassar (p=0,002) Kesimpulan: Coitarche pada usia <15tahun merupakan faktor predisposisi terhadap infeksi HPV dan genotip terbanyak HPV risiko rendah adalah tipe 43 dan 44 pada PSK di Makassar Genotype of Low Risk Type Human Papilloma Virus in Female Commercial Sex Workers in Makassar Abstract Objective: To investigate low-risk HPV genotype through HPV DNA examination and to determine the correlation between risk factors and incidence of HPV infection in Commercial Sex Workers (CSWs) in Makassar. Method: Cross-sectional study was used and conducted in August 2019. The study population was productive CSWs with a total of 80 samples. Result: HPV genotype examination showed low-risk HPV types were dominated by types 43 and 44. Conclusion: Coitarche before 15 years old is a predisposing factor for HPV infection and the highest low-risk HPV genotype is type 43 and 44 in CSWs in Makassar. Key words : HPV Infection in Makassar, Low risk HPV
Profil Pasien Kanker Ovarium yang Dilakukan Fertility Sparing Surgery di RSUP Dr. Hasan Sadikin Bandung Tahun 2017-2020
Authors:   KSM/ Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin Bandung, Athiyazahra Rania Ramadha , Harsono Ali Budi , Bayuaji Hartanto
Published: March 2022

Tujuan: Tujuan penelitian ini untuk menggambarkan karakteristik pasien kanker ovarium yang dilakukan tindakan fertility sparing surgery. Metode: Penelitian deskriptif menggunakan data rekam medis pasien kanker ovarium yang dilakukan tindakan fertility sparing surgery di RSUP Dr. Hasan Sadikin Bandung pada tahun 2017-2020. Sampel yang digunakan sebanyak 35 data rekam medis menggunakan metode total sampling. Hasil: Dari 35 pasien, sebagian besar berusia 20-29 tahun (37%),belum menikah (54%), dan nulipara (71%), Tindakan fertility sparing surgery dilakukan pada stadium I-II untuk tipe sel epitel, stadium I-III untuk tipe sel germinal, dan hanya pada stadium I untuk tipe sel sex cord stromal. Pasien usia <20 tahun dilakukan tindakan fertility sparing surgery pada stadium III dengan jenis histopatologi tipe sel germinal sementara pasien dengan usia>20 tahun mayoritas dilakukan tindakan pada stadium I dengan tipe histopatologi terbanyak adalah tipe sel epitel. Kesimpulan: Tindakan fertility sparing surgery bertujuan untuk mempertahankan organ reproduksi. Karakteristik pasien kanker ovarium yang dapat dilakukan tindakan fertility sparing surgery berusia 20-29 tahun dan nulipara. Tindakan fertility sparing surgery pada tipe sel epitel dan tipe sex cord stromal hanya dilakukan pada stadium dini, sementara pada tipe sel germinal dapat dilakukan hingga stadium III. Ovarian Cancer Patient Profile Undergoing Fertility Sparing Surgery at Dr. Hasan Sadikin General Hospital Bandung From 2017 Until 2020 Abstract Objective: Aimed to describe the characteristics of ovarian cancer patients underwent fertility sparing surgery between 2017-2020 at Dr. Hasan Sadikin General Hospital Bandung. Methods: A descriptive study that used medical records of ovarian cancer patients that underwent fertility sparing surgery at Dr. Hasan Sadikin General Hospital from 2017-2020. The sample used was 35 data, using the total sampling methods. Result: From a total of 35 patients, most were aged 20-29 years (37%), unmarried (54%), and nulliparous (71%). Fertility sparing surgery was performed at stage I-II for epithelial cell, stage I-III for germ cells, and stage I for sex-cord stromal cells. Patients <20 years underwent fertility sparing surgery at stage III with the most common histopathology type is germ cell while patients >20 years underwent fertility sparing surgery at stage I with the histopathology type is surface epithelial cells. Conclusion: Fertility sparing surgery aimed to maintain the reproductive organs. Characteristics of patients who underwent fertility sparing surgery are aged 20-29 years and nulliparous. Fertility sparing surgery can be performed at an early stage for epithelial cell and sex-cord stromal cells, while germ cell can be performed up to stage III. Key words: ovarian cancer, fertility sparing surgery, characteristics
e Comparison of Peripheral Blood Morphology and Ferritin Level in Pregnancy Woman with Anemia Living in Lowland and Highland Areas
Authors:   Obstetrics and Gynecology of Hasanuddin University, Amita Yulfa Rizki , Harton Eddyo , Syahrir Syahruni , Hamid Firdaus , Rambulangi Samrichard , Jusuf Elizabet Catherine
Published: March 2022

Objective: Differences in the morphology features of red blood cells in population groups who live in the lowlands areas and the highlands areas will affect the diagnosis and appropriate therapies. Methods: The method used is a cross-sectional study of 75 pregnant women (6-38 weeks gestational age) with anemia living in highland and lowland areas found at Massenrempulu Hospital and Sitti Khadijah I Hospital. Anemia in pregnant women is diagnosed as a hemoglobin level less than 11gr/dl in the 1st and 3rd trimesters or less than 10.5 gr/dl in the 2nd trimester. The patient's blood sample was taken intravenously and performed serological and peripheral blood examination. Data were processed using the SPSS program, analyzed using univariate and multivariate tests. Results: In both results of the parametric and nonparametric test, ferritin levels showed a significant difference (p = 0.001), higher in the lowland areas group subjects (15.44 ± 36.92) compared to the highland areas group subjects (9.55 ± 30.16). There were no significant differences in morphology features (p> 0.05) between both groups. Conclusion: This study showed no significant differences in morphology features between the two groups. The lowland areas group subjects had a significantly higher ferritin level than that of the highland areas group subjects. Perbandingan Gambaran Morfologi Darah Tepi Pasien Gravid dengan Anemia Yang Tinggal di Pesisir Pantai dan Daerah Pegunungan Abstrak Tujuan: Perbedaan ciri morfologi sel darah merah pada kelompok populasi yang tinggal di dataran rendah dan dataran tinggi akan mempengaruhi diagnosis dan terapi yang tepat. Metode: Metode yang digunakan adalah studi potong lintang pada 75 ibu hamil (usia kehamilan 6-38 minggu) dengan anemia yang tinggal di dataran tinggi dan dataran rendah yang ditemukan di RS Massenrempulu dan RS Sitti Khadijah I. Anemia pada ibu hamil didiagnosis berdasarkan kadar hemoglobin kurang dari 11gr/dl pada trimester I dan III atau kurang dari 10,5 gr/dl pada trimester II. Sampel darah pasien diambil secara intravena dan dilakukan pemeriksaan serologis dan darah tepi. Data diolah menggunakan program SPSS, dianalisis menggunakan uji univariat dan multivariat. Hasil: Pada hasil uji parametrik dan nonparametrik, kadar feritin menunjukkan perbedaan yang secara signifikan (p = 0,001), lebih tinggi pada subjek kelompok dataran rendah (15,44 ± 36,92) dibandingkan dengan subjek kelompok dataran tinggi (9,55 ± 30,16). Tidak ada perbedaan yang signifikan dalam morfologi darah tepi (p> 0,05) antara kedua kelompok. Kesimpulan: Penelitian ini tidak menunjukkan perbedaan morfologi yang signifikan antara kedua kelompok. Subyek kelompok dataran rendah memiliki kadar feritin yang jauh lebih tinggi dibandingkan dengan subjek kelompok dataran tinggi.