bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical practice and transparent reporting in the neurosciences: Preclinical motor behavioral experiments
Authors: Hogue Olivia , Harvey Tucker , Crozier Dena , Sonneborn Claire , Postle Abagail , Block-Beach Hunter , Somasundaram Eashwar , May Francis J. , Snyder Braun Monica , Pasadyn Felicia L. , King Khandi , Johnson Casandra , Dolansky Mary A. , Obuchowski Nancy A. , Machado Andre G. , Baker Kenneth B. , Barnholtz-Sloan Jill S.
Published: March 2022

Longitudinal and behavioral preclinical animal studies generate complex data, which may not be well matched to statistical approaches common in this literature. Analyses that do not adequately account for complexity may result in overly optimistic study conclusions, with consequences for reproducibility and translational decision-making. Recent work interrogating methodological shortcomings in animal research has not yet comprehensively investigated statistical shortcomings in the analysis of complex longitudinal and behavioral data. To this end, the current cross-sectional meta-research study rigorously reviewed published mouse or rat controlled experiments for motor rehabilitation in three neurologic conditions to evaluate statistical choices and reporting. Medline via PubMed was queried in February 2020 for English-language articles published January 1, 2017- December 31, 2019. Included were articles that used rat or mouse models of stroke, Parkinson’s disease, or traumatic brain injury, employed a therapeutic controlled experimental design to determine efficacy, and assessed at least one functional behavioral assessment or global evaluation of function. 241 articles from 99 journals were evaluated independently by a team of nine raters. Articles were assessed for statistical handling of non-independence, animal attrition, outliers, ordinal data, and multiplicity. Exploratory analyses evaluated whether transparency or statistical choices differed as a function of journal factors. A majority of articles failed to account for sources of non-independence in the data (74–93%) and/or did not analytically account for mid-treatment animal attrition (78%). Ordinal variables were often treated as continuous (37%), outliers were predominantly not mentioned (83%), and plots often concealed the distribution of the data (51%) Statistical choices and transparency did not differ with regards to journal rank or reporting requirements. Statistical misapplication can result in invalid experimental findings and inadequate reporting obscures errors. Clinician-scientists evaluating preclinical work for translational promise should be mindful of commonplace errors. Interventions are needed to improve statistical decision-making in preclinical behavioral neurosciences research.
Design, development, and characterization of amorphous rosuvastatin calcium tablets
Authors: González Rocío , Peña Mª Ángeles , Torres Norma Sofía , Torrado Guillermo
Published: March 2022

This work proposes a methodology for the design, development, optimisation, and evaluation of amorphous rosuvastatin calcium tablets (BCS class II drug). The main goal was to ensure rapid disintegration and high dissolution rate of the active ingredient, thus enhancing its bioavailability. The design started from a careful selection of excipients, which due to their characteristics and proportions within the formulation allowed the use of their properties such as fluidity or granulometric distribution. The formulation was characterised using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR) and powder X-ray diffraction (PXRD) methods. The galenic SeDeM methodology was used to establish the profile of the active ingredient-excipient mixture and guarantee its suitability for producing tablets by the direct compression method. The results demonstrate that the amorphous rosuvastatin calcium tablets formulation developed made it possible to obtain cost-effective tablets by direct compression with optimal pharmacotechnical characteristics that showed a remarkable disintegration and dissolution rate. The manufactured tablets complied with the pharmacopoeia guidelines regarding content uniformity, tablet hardness, thickness, friability, in vitro disintegration time and dissolution profile.
The epidemiology and outcomes of central nervous system infections in Far North Queensland, tropical Australia; 2000-2019
Authors: Gora Hannah , Smith Simon , Wilson Ian , Preston-Thomas Annie , Ramsamy Nicole , Hanson Josh
Published: March 2022

Background

The epidemiology of central nervous system (CNS) infections in tropical Australia is incompletely defined.

Methods

A retrospective study of all individuals in Far North Queensland, tropical Australia, who were diagnosed with a CNS infection between January 1, 2000, and December 31, 2019. The microbiological aetiology of the infection was correlated with patients’ demographic characteristics and their clinical course.

Results

There were 725 cases of CNS infection during the study period, meningitis (77.4%) was the most common, followed by brain abscess (11.6%), encephalitis (9.9%) and spinal infection (1.1%). Infants (24.3%, p<0.0001) and Aboriginal and Torres Strait Islander Australians (175/666 local residents, 26.3%, p<0.0001) were over-represented in the cohort.

A pathogen was identified in 513 cases (70.8%); this was viral in 299 (41.2%), bacterial in 175 (24.1%) and fungal in 35 (4.8%). Cryptococcal meningitis (24 cases) was diagnosed as frequently as pneumococcal meningitis (24 cases). There were only 2 CNS infections with aS.pneumoniaeserotype in the 13-valent pneumococcal vaccine after its addition to the National Immunisation schedule in 2011. Tropical pathogens–includingCryptococcus species(9/84, 11%),Mycobacterium tuberculosis(7/84, 8%) andBurkholderia pseudomallei(5/84, 6%)–were among the most common causes of brain abscess. However, arboviral CNS infections were rare, with only one locally acquired case—a dengue infection in 2009—diagnosed in the entire study period. Intensive Care Unit admission was necessary in 14.3%; the overall case fatality rate was 4.4%.

Conclusion

Tropical pathogens cause CNS infections as commonly as traditional bacterial pathogens in this region of tropical Australia. However, despite being highlighted in the national consensus guidelines, arboviruses were identified very rarely. Prompt access to sophisticated diagnostic and supportive care in Australia’s well-resourced public health system is likely to have contributed to the cohort’s low case-fatality rate.
Jordanian views regarding sharing of medical data for research: A cross-sectional study during COVID-19 pandemic
Authors: Khatatbeh Moawiah , Gharaibeh Lobna F. , Khabour Omar F. , Abu-Farha Rana K. , Alzoubi Karem H.
Published: March 2022

Purpose

In the current study, the views of Jordanian regarding sharing medical reports for research purposes were investigated during the COVID-19 pandemic. In addition, motivators and barriers regarding sharing of medical records were examined.

Methods

This observational survey-based cross-sectional study was conducted using an electronic questionnaire during the COVID-19 pandemic (second half of 2020). The questionnaire link was disseminated through two social media platforms (WhatsApp and Facebook), targeting Jordanian adults (age >18 years).

Results

In this study, 1,194 participants agreed to complete the study survey. Results showed that 58.3% of them (n = 696) reported to be willing to share their medical data. while 17.6% of the participants (n = 210) showed hesitancy to share their medical information. The most important motivators as perceived by the study participants were helping other patients who have similar health conditions (n = 995, 83.3%). Moreover, fearing from stigma (n = 753, 63.1%), and the lack of confidence in data security and privacy (n = 728, 61.0%) were among the main barriers preventing participants from sharing their information. Finally, results showed that participants with higher educational level (bachelor or higher) (OR = 0.299, P<0.001), or those living in center of Jordan (OR = 0.270, P<0.001) showed a lower tendency to share their medical data. While participants those who have shared data before showed a higher tendency to share their medical data (OR = 2.524, P<0.001).

Conclusion

In this study, many of the participants had a positive attitude towards sharing biomedical data for scientific research during the COVID-19 pandemic, many had doubts in the control over their data. Thus, policymakers and data users should address the concerns and values of patients and understand their preferences in favor of an ethically scrupulous use of data in research.
Detection of SARS-CoV-2 and the L452R spike mutation using reverse transcription loop-mediated isothermal amplification plus bioluminescent assay in real-time (RT-LAMP-BART)
Authors: Iijima Takahiro , Ando Shinnosuke , Kanamori Dai , Kuroda Kazumichi , Nomura Tsutomu , Tisi Laurence , Kilgore Paul E. , Percy Neil , Kohase Hikaru , Hayakawa Satoshi , Seki Mitsuko , Hoshino Tomonori
Published: March 2022

The new coronavirus infection (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be fatal, and several variants of SARS-CoV-2 with mutations of the receptor-binding domain (RBD) have increased avidity for human cell receptors. A single missense mutation of U to G at nucleotide position 1355 (U1355G) in the spike (S) gene changes leucine to arginine (L452R) in the spike protein. This mutation has been observed in the India and California strains (B.1.617 and B.1.427/B.1.429, respectively). Control of COVID-19 requires rapid and reliable detection of SARS-CoV-2. Therefore, we established a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay plus a bioluminescent assay in real-time (BART) to detect SARS-CoV-2 and the L452R spike mutation. The specificity and sensitivity of the RT-LAMP-BART assay was evaluated using synthetic RNAs including target sequences and RNA-spiked clinical nasopharyngeal and saliva specimens as well as reference strains representing five viral and four bacterial pathogens. The novel RT-LAMP-BART assay to detect SARS-CoV-2 was highly specific compared to the conventional real-time RT-PCR. Within 25 min, the RT-LAMP-BART assay detected 80 copies of the target gene in a sample, whereas the conventional real-time RT-PCR method detected 5 copies per reaction within 130 min. Using RNA-spiked specimens, the sensitivity of the RT-LAMP-BART assay was slightly attenuated compared to purified RNA as a template. The results were identical to those of the conventional real-time RT-PCR method. Furthermore, using a peptide nucleic acid (PNA) probe, the RT-LAMP-BART method correctly identified the L452R spike mutation. This is the first report describes RT-LAMP-BART as a simple, inexpensive, rapid, and useful assay for detection of SARS-CoV-2, its variants of concern, and for screening of COVID-19.
Creating a Makaton Mass: A composition for unison voices and piano to be sung and signed using Makaton
Authors: Sparkhall Olivia
Published: March 2022

This article charts the composition of the Multitude of Voyces’ Makaton Mass, commissioned by Multitude of Voyces. This is the first Mass of its kind, devised to be simultaneously sung and signed using the communication programme Makaton. In this article, I propose that to be inclusive, music for worship needs to be all-embracing: straight-forward, but not simplistic, and easily memorable without being twee. Opportunity for congregational participation for both those with special educational needs and disability (SEND) and those without is at the heart of a successful composition of this sort.
Quantum description of angles in the plane
Authors: Beneduci Roberto , Frion Emmanuel , Gazeau Jean-Pierre
Published: March 2022

The real plane with its set of orientations or angles in [0, π) is the simplest non trivial example of a (projective) Hilbert space and provides nice illustrations of quantum formalism. We present some of them, namely covariant integral quantization, linear polarisation of light as a quantum measurement, interpretation of entanglement leading to the violation of Bell inequalities, and spin one-half coherent states viewed as two entangled angles.
Maxwell-Chern-Simons-Higgs theory
Authors: Kulshreshtha Usha , Kulshreshtha Daya Shankar , Sihagb Bheemraj
Published: March 2022

We consider the three dimensional electrodynamics described by a complex scalar field coupled with the U(1) gauge field in the presence of a Maxwell term, a Chern-Simons term and the Higgs potential. The Chern-Simons term provides a velocity dependent gauge potential and the presence of the Maxwell term makes the U(1) gauge field dynamical. We study the Hamiltonian formulation of this Maxwell-Chern-Simons-Higgs theory under the appropriate gauge fixing conditions.
Rational extension of many particle systems
Authors: Mandal Bhabani Prasad
Published: March 2022

In this talk, we briefly review the rational extension of many particle systems, and is based on a couple of our recent works. In the first model, the rational extension of the truncated Calogero-Sutherland (TCS) model is discussed analytically. The spectrum is isospectral to the original system and the eigenfunctions are completely expressed in terms of exceptional orthogonal polynomials (EOPs). In the second model, we discuss the rational extension of a quasi exactly solvable (QES) N-particle Calogero model with harmonic confining interaction. New long-range interaction to the rational Calogero model is included to construct this QES many particle system using the technique of supersymmetric quantum mechanics (SUSYQM). Under a specific condition, infinite number of bound states are obtained for this system, and corresponding bound state wave functions are written in terms of EOPs.
On generalized Heun equation with some mathematical properties
Authors: Saad Nasser
Published: March 2022

We study the analytic solutions of the generalized Heun equation, (α0 + α1 r + α2 r2 + α3 r3) y′′ + (β0 + β1 r + β2 r2) y′ + (ε0 + ε1 r) y = 0, where |α3| + |β2|≠ 0, and {αi}3i=0, {βi}2i=0, {εi}1i=0 are real parameters. The existence conditions for the polynomial solutions are given. A simple procedure based on a recurrence relation is introduced to evaluate these polynomial solutions explicitly. For α0 = 0, α1≠ 0, we prove that the polynomial solutions of the corresponding differential equation are sources of finite sequences of orthogonal polynomials. Several mathematical properties, such as the recurrence relation, Christoffel-Darboux formulas and the norms of these polynomials, are discussed. We shall also show that they exhibit a factorization property that permits the construction of other infinite sequences of orthogonal polynomials.
Analysis, Management and Trade-off with Risks of Technical Facilities
Authors: Procházková Dana , Procházka Jan
Published: March 2022

Submitted work “Analysis, management and trade-off with risk of technical facilities“ deals with the all type of risks associated with the technical facilities, particularly with the complex ones, with aim to ensure their safety. It demonstrates the ways of work with risks at phase of identification, analysis, assessment, management and putting under control aimed to the safety of both, the technical facilities and their surround-ings (i.e. their mutual coincidence), and simultaneously respecting the current knowledge that the risks are locally and time-specific. The safety is understood as a property on the level of the whole technical facility, which is determined by the quality of the file of anthropogenic measures and activi-ties aimed at the safe technical facility, and even at its critical conditions. Therefore, at safety make up, the publication proposes to monitor both, the public assets and the technical facility´ assets, and together to consider the diversity of their physical natures, vulnerabilities, and the constituent changes over time; which means contin-uously to solve emerging conflicts. procedures for the control and management of critical sit-uations. The publication “Analysis, management and trade-off with risks of technical facilities“ summarizes problems and shows methods and procedures for their solution based on system concept and present findings and experiences from practice obtained by detail research. It summarizes the results of specific research performed in project “Řízení rizik a bezpečnost složitých technologických objektů (RIRIZIBE)“ CZ.02.2.69/0.0/ 0.0/16_018/000”; detail data and results are in the Czech publication and in the CVUT archives.
Biosynthesis of Gold Nanoparticles Mediated by Andaliman Fruit Water Extract and Its Application as Antioxidants
Authors: Lestari Gusti Ayu Dewi , Cahyadi Kadek Duwi
Published: March 2022

Plant extract-mediated green synthesis of gold nanoparticles (AuNPs) is currently gaining significant interest in the field of nanotechnology. In this study, AuNPs were synthesized using an aqueous extract of Andaliman fruit (Zanthoxylum acanthopodium DC.). The formation of AuNPs was confirmed by observing the color change of the solution from clear to cherry red. The reaction parameters, namely the extract concentration and the ratio of the mixture of the extract with HAuCl4 solution, were optimized for the AuNPs biosynthesis. The gold nanoparticles were characterized using a UV-Vis spectrophotometer, SEM-EDS, and particle size analyzer. The characterization suggested that AuNPs had a maximum wavelength ranging of 540–559 nm, with spherical crystals morphology where the highest component was gold at 36.01% and the size below 100 nm on average. The antioxidant activity of the synthesized AuNPs was determined using the DPPH method. It showed that the highest free radical scavenging activity was 83%, given by 20 ppm AuNPs.
Catalytic hydrogenation of stearic acid to 1-octadecanol using supported bimetallic Pd–Sn(3.0)/γ–Al2O3 catalyst
Authors: Azzahra Atina Sabila , Hayati Elisa , Rodiansono Rodiansono
Published: March 2022

Supported bimetallic palladium-tin catalyst on gamma-alumina (γ-Al2O3) (denoted as Pd–Sn(3.0)/γ-Al2O3; Pd = 5%wt and Pd/Sn molar ratio is 3.0) has been synthesized via the hydrothermal method at a temperature of 423 K for 24 h and reduced with H2 at 673 K for 3 h. The XRD patterns of the samples showed typical diffraction peaks of support γ-Al2O3, metallic Pd, Sn, and Pd–Sn alloy phases. Diffraction peaks of metallic Pd were observed at 2θ = 39.8°; 46.6°; and 68.0°, which can be attributed to the Pd(111), Pd(200), and Pd(220), respectively, while the diffraction peaks at 2θ = 39.8° and 41.0° can be attributed to Pd2Sn and Pd3Sn2, respectively, which may overlap with the Pd(111) species. The ammonia desorption and pyridine adsorption profiles showed Lewis and Brönsted acid sites. The specific surface area (SBET) of Pd–Sn(3.0)/γ-Al2O3 catalyst was 117.83 m2/g which is dominated by a micropore structure. The highest conversion of stearic acid was 99.1% with a yield of 1-octadecanol 43.2% was obtained at temperature 513 K, initial H2 pressure of 2.0 MPa, a reaction time of 13 h, and in 2-propanol/water (4.0:1.0 v/v) solvent.
The Interpretation of Gregor's Transformation in The Metamorphosis from the Perspective of Existentialism
Authors: Anheng Li
Published: March 2022

The Metamorphosis is one of the greatest novels written by Franz Kafka in 1915, which depicts the surreal and absurd transformation of Gregor Samsa into a beetle. Existentialism is borrowed to help interpret the implications of Gregor's transformation. After the transformation, Gregor lives in hatred, dread, absurdity, hopelessness, helplessness and despair. He is isolated, estranged, alienated by his family and the society. Centering on Gregor's transformation, this paper discovers that the authentic existing situation of the underprivileged is entirely revealed in this novella; the pathetic dark side of the human existence is vividly depicted and presented via transformation by Franz Kafka, who meanwhile deeply explores the negative sensations of human existence.
Calorimetry of extracellular vesicles fusion to single phospholipid membrane
Authors: Grava Miriam , Helmy Sally , Gimona Mario , Parisse Pietro , Casalis Loredana , Brocca Paola , Rondelli Valeria
Published: March 2022

Extracellular vesicles (EVs)-mediated communication relies not only on the delivery of complex molecular cargoes as lipids, proteins, genetic material, and metabolites to their target cells but also on the modification of the cell surface local properties induced by the eventual fusion of EVs’ membranes with the cells’ plasma membrane. Here we applied scanning calorimetry to study the phase transition of single phospholipid (DMPC) monolamellar vesicles, investigating the thermodynamical effects caused by the fusion of doping amounts of mesenchymal stem cells-derived EVs. Specifically, we studied EVs-induced consequences on the lipids distributed in the differently curved membrane leaflets, having different density and order. The effect of EV components was found to be not homogeneous in the two leaflets, the inner (more disordered one) being mainly affected. Fusion resulted in phospholipid membrane flattening associated with lipid ordering, while the transition cooperativity, linked to membrane domains’ coexistence during the transition process, was decreased. Our results open new horizons for the investigation of the peculiar effects of EVs of different origins on target cell membrane properties and functionality.
Rough set-based entropy measure with weighted density outlier detection method
Authors: Sangeetha Tamilarasu , Geetha Mary Amalanathan
Published: March 2022

The rough set theory is a powerful numerical model used to handle the impreciseness and ambiguity of data. Many existing multigranulation rough set models were derived from the multigranulation decision-theoretic rough set framework. The multigranulation rough set theory is very desirable in many practical applications such as high-dimensional knowledge discovery, distributional information systems, and multisource data processing. So far research works were carried out only for multigranulation rough sets in extraction, selection of features, reduction of data, decision rules, and pattern extraction. The proposed approach mainly focuses on anomaly detection in qualitative data with multiple granules. The approximations of the dataset will be derived through multiequivalence relation, and then, the rough set-based entropy measure with weighted density method is applied on every object and attribute. For detecting outliers, threshold value fixation is performed based on the estimated weight. The performance of the algorithm is evaluated and compared with existing outlier detection algorithms. Datasets such as breast cancer, chess, and car evaluation have been taken from the UCI repository to prove its efficiency and performance.
Prediction of insulin therapy in women with gestational diabetes: a systematic review and meta-analysis of observational studies
Authors: Alvarez-Silvares Esther , Bermúdez-González Mónica , Vilouta-Romero Martina , García-Lavandeira Sandra , Seoane-Pillado Teresa
Published: March 2022

Objectives

To identify antenatal risk factors that may predict the need for insulin treatment upon diagnosis of gestational diabetes (GDM), that is, to identify the specific characteristics of women diagnosed with GDM who did not achieve good glycemic control through lifestyle modifications.

Methods

We performed a comprehensive literature search in PubMed, Science Direct, Ebsco, and Scielo for studies evaluating the associations between antenatal factors and the need for insulin treatment published until January 28th, 2021. Random-effects models were used to estimate risk ratios and their 95% confidence interval. The quality of studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as risk ratio and their 95% confidence interval. The systematic review and meta-analysis were registered in the International Prospective Register of Systematic Reviews.

Results

Eighteen observational studies were selected, reporting 14,951 women with GDM of whom 5,371 received insulin treatment. There were statistically significant associations between the need for insulin treatment and BMI ≥ 30 (RR:2.2; 95%CI: 1.44–3.41), family history of type 2 diabetes mellitus (RR:1.74; 95%CI: 1.56–1.93), prior personal history of GDM (RR:2.10; 95%CI: 1.56–2.82), glycated hemoglobin value at GDM diagnosis (RR:2.12; 95%CI: 1.77–2.54), and basal glycemia obtained in the diagnostic curve (RR: 1.2; 95%CI: 1.12–1.28). Nulliparity and maternal age were not determinants factor. There was moderate-to-high heterogeneity among the included studies.

Conclusions

the strong causal association between BMI ≥ 30, family history of type 2 diabetes mellitus, prior history of GDM and glycosylated hemoglobin with the need for insulin treatment was revealed.
Origin and development of the suffix -ARÍA in Romance
Authors: Rainer Franz
Published: March 2022

The origin and development of the compound suffix -ARÍA in (Latin and) Romance has repeatedly been addressed in works on the history of Romance word formation, without however reaching a broad consensus. In the present article, the problem is discussed again from a pan-Romance perspective and on a broad factual basis. The first chapter argues that the compound suffix’s second element, i.e. -ÍA, was already highly polysemous in (late) Latin and that the Romance languages inherited this polysemy. It is therefore misguided to treat the semantic fragmentation of the suffix as a process that took place independently in the single Romance languages. We then turn to a description of the single Romance languages and dialects, treating first the state of the art for each of these and then presenting the different patterns that can be observed, especially in the older stages. The next chapter looks at the single patterns one by one, discussing to what extent they are present in each Romance language and at the dialectal level. The lexemes that turned out to be crucial from a diachronic perspective receive special attention. The final chapter summarizes the main findings, which depart in important ways from traditional wisdom.
Saña y codicia como conceptos rectores de la miscelánea castellana del ms. Salamanca, Biblioteca Universitaria, 1877
Authors: Casais Alejandro
Published: March 2022

Salamanca, University Library, MS 1877 (1469–1470) is a miscellany made up of genetically independent works, all in Castilian: the Fuero real by Alfonso X; a translation of the Barlaam et Josaphat; sayings of the desert fathers taken from the Vitae patrum of Pelagius and John; a translation of John of Rupescissa’s Vade mecum in tribulatione; segments of three French Arthurian romances (Libro de Josep Abarimatia, Estoria de Merlín and Lançarote); a short catechism with no known direct source. But it is also miscellaneous because, as usually occurs in these compilations, the collected works belong to different textual genres: code of law; oriental didactic literature; hagiographic and apocalyptic discourses; Arthurian romance; catechetical compendium. Taking materialist philology as a theoretical framework, this article will propose a unitary reading of the manuscript from the hypothesis that among its dissimilar components there are semantic ties that give it a specific coherence and meaning. We will claim that the codex explores a series of exemplary variations destined to reprove the excess of irascible (saña) and concupiscible (codicia) appetites that those who dedicate themselves to active life tend to experience against the virtues of justice and prudence that are essential to access contemplative life.
Contatti linguistici lungo le coste tirreniche: storia della parola marruffo
Authors: Retaro Valentina
Published: March 2022

The article intends to reconstruct the linguistic history of a particular fishing gear called marruffo, which is still used in the Gulf of Naples and in a few places of the North Tyrrhenian coasts. The marruffo is a fishing trap used by fishermen to preserve the catch while awaiting sale. Conical in shape, it looks like a large basket with a lid, in which fish or crustaceans of various types are placed. Starting from the 1871 work by the naturalist Achille Costa, entitled La pesca nel golfo di Napoli, the attestations of marruffo in Campania, Sardinia and Corsica are outlined. I put forward the hypothesis that the object arrived on the Tyrrhenian coasts as a consequence of migrations of fishermen from the Neapolitan area to the islands of Tuscany, Sardinia and Corsica between the 18th and 19th century. Since in southern Italy the name marruffo also indicates a jug for wine or water, I hypothesize that the word was extended from the lexicon of everyday life to the fishing lexicon throughout a process of resemantization, as it was demonstrated for other similar cases.
Sardo thurpu ‘cieco’: un grecismo tra sostrato e latinità
Authors: Areddu Alberto G.
Published: March 2022

The article discusses the origin of Sardinian thurpu ‘blind’, which some authors consider as part of the Prelatin autochthonous stratum (Wagner, Tagliavini, Rohlfs), whereas others assume that it is borrowing from Southern Italian Greek (Ribezzo, Tuttle). In conclusion, the second hypothesis seems more likely, even if the Greek term may well have been present in Sardinia before the arrival of the Romans.
Spanen gefüllter Kunststoffe
Authors: Spur Günter , Lachmund Uwe
Published: March 2022

Aufgrund ihrer Eigenschaften steigt die Verwendung von Bauteilen aus gefüllten Kunststoffen. Für die Wirtschaftlichkeit der spanenden Fertigung ist somit die Auswahl geeigneter Werkzeuge und Beschichtungen von großer Bedeutung. Der folgende Beitrag beschäftigt sich mit dem Fräsen und Bohren dieser Werkstoffe unter Verwendung unbeschichteter und beschichteter Werkzeuge.
Toleranzen in der Zeitwirtschaft*
Authors: Westkämper Engelbert , Hüser Manfred
Published: March 2022

Das Wissen über geometrische Toleranzen und deren gezielte Nutzung sind Stand der Technik in der industriellen Produktion. In diesem Beitrag wird beschrieben, daß auch die Durchführung für Produktionsvorgänge toleranzbehaftet ist und dementsprechend behandelt werden sollte.
Beschäftigungsorientierte Rationalisierung
Authors: Wiendahl Hans-Peter , Krüger Thomas , Röhrig Martin
Published: March 2022

Die bisherige Strategie zur Rationalisierung der Produktion ist durch das starke Streben nach einer hohen Automatisierung geprägt. Die tatsächlichen Kosten dieser Produktionsstrukturen werden jedoch kaum erfaßt und bewertet. Der vorliegende Beitrag beschreibt einen Ansatz, mit dem die menschliche Arbeitskraft durch eine realistische Betrachtung neu bewertet werden kann.
Erfolgreich auf dem Weg zum wandlungsfähigen Unternehmen
Authors: Widmaier Gerald , Greth Torsten
Published: March 2022

Auch Unternehmen der Einzelfertigung sehen sich in zunehmendem Maße mit einem turbulenten Umfeld und immer höheren Kundenanforderungen konfrontiert. Hierzu ist es notwendig, die Organisationsstrukturen wandlungsfähig zu gestalten. In diesem Beitrag werden anhand eines Fallbeispiels die positiven Effekte bezüglich der Verbesserung der Kundenorientierung bei gleichzeitiger Effizienzsteigerung aufgezeigt.
Neue Modelle der Entgeltgestaltung
Authors: Bullinger Hans-Jörg , Bauer Siegfried
Published: March 2022

Die Qual der Wahl spielt auch bei der Implementierung von neuen Entgeltsystemen eine große Rolle. Durch diesen Beitrag kann zwar keine betriebsspezifische Auswahl und Anpassung erfolgen, aber eine Vorgehensweise vermittelt werden, die den Versuch unternimmt, systematisch verschiedene Aspekte aus Unternehmens- und Mitarbeitersicht im Entscheidungsprozeß zu berücksichtigen.
Egy amerikai fényképész Magyarországon
Authors: Somogyvári Lajos
Published: March 2022

Napjainkban egyre több adatbázis vélik digitálisan elérhetővé, mind a szöveges, mind a vizuális forrásokat tekintve (a pandémiás helyzet ezt a folyamatot csak felerősítette) – a kutatás számára ez egyre bővülő lehetőségeket nyit meg, több perspektívát kínálva a közelmúlt történetének kutatásához. A tanulmányban a neves amerikai fényképész, utazó és újságíró, Harrison Forman 1960-as magyarországi látogatásának fotóanyagát használva mutatom be a képelemzések társadalomtörténeti hasznosíthatóságát. A University of Wisconsin-Milwaukee Libraries honlapján közzétett gyűjtemény nemcsak a képeket tartalmazza, hanem azt az úti jegyzetfüzetet, naplót is, amibe Forman a benyomásait jegyzetelte és ez a forrás jól kiegészíti az elemzést. A korban egyedülálló színes képek a mindennapok társadalomtörténetéhez fontos adalékot nyújt, a kollektivizálás, az iparosítás, a fogyasztás és kultúra számos területét lefedve, a régi és az új, modernizálódó világ átmenetiségét jól bemutatva. 

Fotó:  Amerikai Földrajzi Társaság Könyvtára, Milwaukee-i Wisconsini Egyetemi Könyvtárak
Hatvan év az anatómiai kutatás és oktatás pécsi műhelyében
Authors: Dezső Krisztina
Published: March 2022

Flerkó Béla (1924–2003) professzor meghatározó személyisége volt a Pécsi Orvostudományi Egyetem oktatói-kutatói gárdájának. Orvosi tanulmányait kitüntetéssel végezte az Erzsébet Tudományegyetemen. 1946-tól dolgozott a Szentágothai János által vezetett Anatómiai Intézetben. 1964-től kapott tanszékvezetői megbízást, melyet 1992-ig látott el. A Pécsi Orvostudományi Egyetem rektoraként is tevékenykedett 1979 és 1985 között. Fő kutatási területe a neuroendokrinológia, főként az agyalapi mirigy neurohormonális működése és szabályozási folyamatai, valamint szaporodásbiológiai kérdések. 1982-tól az MTA rendes tagja. Eredményeinek elismeréseként többször kapott meghívást külföldi kutatóintézetbe (UCLA, Maryland Egyetem). Meghívott "Geoffrey Harris Memorial Lecture" előadó 1979-ben. Több rangos hazai és nemzetközi tudományos szervezetben volt vezető és tag. A legjelentősebbek ezek közül a Nemzetközi Agykutató Társaság (IBRO) tagsága, valamint Nemzetközi Endokrinológiai Társaság, ahol elnöki pozíciót is betöltött.   

Fotó: Pécsi Egyetemtörténeti Gyűjtemény
Heterogeniško finansializacijos poveikio ilgojo laikotarpio ekonomikos augimui vertinimas
Authors:   , Šetikienė Agnė
Published: March 2022

The Heterogeneous Impact of Financialisation on Long-run Economic Growth
VOLTAGE AND REACTIVE POWER REGULATION IN DISTRIBUTION NETWORKS BY THE MEANS OF DISTRIBUTED RENEWABLE ENERGY SOURCES
Authors:   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine, Blinov I.V. , Trach I.V. ,   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine, Parus Ye.V. ,   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine, Derevianko D.G. ,   National Technical University of Ukraine Igor Sikorsky Kyiv Polytechnic Institute, pr. Peremohy, 37, Kyiv, 03056, Ukraine, Khomenko V.M. ,   Institute of Electrodynamics National Academy of Science of Ukraine, Pr. Peremohy, 56, Kyiv, 03057, Ukraine
Published: March 2022

The problems of mode regulation of distribution networks in Ukraine are investigated in this paper. Authors propose to regulate the modes of distribution networks by the means of convertors of renewable energy sources (solar power plants etc.) connected to this networks according to the Smart Grid concept. The analysis of multicriteria mode optimization results of the distribution network was performed and the most perspective criterion were selected according to the features of structure and functioning of distribution networks in Ukraine. The target function of multicriteria optimization by the criteria of minimization of reactive power on the main section of the line and minimization of standard voltage deviations from the nominal value is formalized by the authors. To calculate the optimal value for the target function, the Multivariable extremum seeking control method was chosen, this method was improved by adding additional filters of individual frequency channels. An example of calculations is given in the paper; it illustrates the efficiency of the proposed method of modes regulating of the distribution networks. References 24, figures 3, tables 2.
Multiple sklerozlu egzersiz alışkanlığı olan ve olmayan kadın hastalarda alt üriner sistem semptomları ve yaşam kalitesinin karşılaştırılması
Authors: BÜLBÜL Saliha Beste , KESER İlke , YÜCESAN Canan , TOPRAK ÇELENAY Şeyda
Published: March 2022

Amaç: Bu çalışmanın amacı Multiple Skleroz (MS) tanılı egzersiz alışkanlığı olan ve olmayan kadın hastalarda alt üriner sistemsemptomları (AÜSS) ve yaşam kalitesini karşılaştırmaktı.Yöntem: Çalışmaya kırk iki MS tanılı kadın hastalar dahil edildi. Hastalar egzersiz alışkanlığı olanlar (n=20) ve olmayanlar(n=22) olarak iki gruba ayrıldı. Egzersiz alışkanlığı, son 3 ay boyunca haftada en az 3 gün ve günlük 20 dakikadan uzun sürmüşolan aktivitelerin varlığına göre belirlendi. AÜSS, Uluslararası İnkontinans Konsültasyon Sorgulama Ölçeği-Kadın Alt ÜrinerSistem Semptomları ölçeği ile ve yaşam kalitesi King Sağlık Anketi (KSA) ile değerlendirildi.Bulgular: Egzersiz alışkanlığı olan MS’li kadınlarda egzersiz alışkanlığı olmayan MS’li kadınlara göre inkontinans semptomları,KSA’nın duygular (p=0,023) ve ciddiyet (p=0,010) alt grup skorları daha azdı (p=0,009). Depolama (p=0,265) ve boşaltım(p=0,734) semptom skorları, KSA’nın genel sağlık (p=0,462), idrar problemi (p=0,215), rol kısıtlaması (p=0,447), fizikselkısıtlılık (p=0,207), sosyal kısıtlılık (p=0,287), kişisel ilişkiler (p=0,128) ve uyku-enerji (p=0,478) alt grup skorları gruplararasında benzerdi.Sonuç: MS tanılı egzersiz alışkanlığı olan kadınların egzersiz alışkanlığı olmayan kadınlara göre inkontinans semptomlarınıdaha az yaşadığı ve yaşam kalitesinin bazı parametrelerinin daha iyi olduğu bulundu. Bu sonuçlar, MS tanılı kadın hastalarda,egzersiz alışkanlığına sahip olmanın özellikle inkontinans semptomları ve yaşam kalitesinde iyileşmeye katkı sağlayabileceğinigöstermektedir.
EXPERIENCE OF DIGITAL TRANSFORMATION OF THE PROVISION OF STATE AND MUNICIPAL SERVICES IN THE TULA REGION
Authors:   Ministry of Education of the Tula Region, Reshetko Laura , Smirnova Svetlana ,   Tula State University
Published: March 2022

The article considers the necessity, basic principles and goals of digital transformation of public administration, summarizes the results of work in the region to create conditions and infrastructure for the development of the digital economy and digital transformation of public administration, describes the experience of implementing a pilot project in the Tula region to create a superservice "Birth of a Child", identifies possible risks of digitalization of the provision of state and municipal services.
DIGITALIZATION OF THE STATE CIVIL SERVICE: REGULATORY AND LEGAL ASPECT
Authors:   Perm National Research Polytechnic University, Koldushko Anna
Published: March 2022

The article is devoted to the actual topic-the implementation of digital economy approaches in the sphere of the state civil service of the Russian Federation. The main problems of the regulatory legal regulation of the digitalization of the civil service, the ways of their improvement are considered. The author believes that the most promising way to achieve this goal is the definition and normative consolidation of the model of "digital competencies" of a civil servant, as well as the detailed elaboration of this model in the official regulations.
DIGITAL CHALLENGES OF IMPLEMENTING REGIONAL PROGRAMS TO LOCAL INITIATIVES
Authors:   Tver state University, Lapushinskaya Galina
Published: March 2022

The features of the implementation of regional programs to support local initiatives during the pandemic are analyzed. The advantages and disadvantages of implementing digital communication in the process of initiative budgeting are identified. Possible directions for improving the interaction of municipal administrations with communities of residents are proposed.
APPLICATION OF INFORMATION TECHNOLOGIES IN THE SPHERE OF MANAGING TKO
Authors:   Perm National Research Polytechnic University, Platonova Veronika
Published: March 2022

The purpose of this article is to analyze the foreign and Russian practice of introducing information technologies in the sphere of managing solid municipal waste. The main trends in digitalization in the sphere of managing TKO are analyzed, including application of information technology in the planning and management process, technologization direct contact with TKO. The most successful practices of digitalization of TKO management in a number of foreign countries have been identified. The features of the implementation of information technologies in the Russian Federation are investigated. Conclusions are made about the prospects for digitalization of the TKO industry for the environmental and economic spheres in the Russian Federation.
DIGITAL TECHNOLOGIES FOR ENERGY INFRASTRUCTURE CONTROL OF URBAN AGREEMENT UNDER EMERGENCY AND SPECIAL PERIODS
Authors:   Situational Analytical Center of the Ministry of Energy of Russia, Loginov Evgeny , Ivanov Valeriy ,   Situational Analytical Center of the Ministry of Energy of Russia
Published: March 2022

The problems of adaptation of energy infrastructure management systems of urban agglomerations to work in emergency situations and in a special period are analyzed. It is proposed to form secure data centers serving the most important infrastructure systems of urban agglomerations, primarily in the field of energy and housing and communal services. The considered technological solutions make it possible to obtain the most optimal ratio of performance and cost of the system in relation to the problem of ensuring the reliability of power supply to urban consumers, taking into account possible critical impacts of a natural and man-made nature, including possible information network attacks.
SOCIOLOGICAL ASPECTS OF DIGITALIZATION
Authors:   College of State and Municipal Service, branch in Ulyanovsk, Gunbina Svetlana
Published: March 2022

The article analyzes the problems of the impact of digitalization on social relationship. Using a sociological approach, the impact of digitalization on social relations is analyzed. The problems associated with the reduction of human involvement in the system of social relations are identified and the directions of over-coming the negative consequences of digitalization are identified.
PREVENTION OF LABOUR CRIMES AT MOTOVILIKHINSKY PLANT DURING THE GREAT PATRIOTIC WAR
Authors:   Perm National Research Polytechnic University, Belonogov Yury
Published: March 2022

The multidimensional problem of violations of labor discipline at the district-forming enterprise of Perm during the Great Patriotic War is considered. The main methods of prevention of labour crimes are analyzed in the context of the solution at plant No. 172 of those socioeconomic problems that influenced the growth of negative labour deviations. The author concludes that the set of measures taken corresponded to changes in the legislation on the consolidation of the labor force, and their practical implementation depended on the limited resources of the enterprise. Despite some effectiveness of measures, the problem of labor crimes continued to be urgent for objective reasons, independent of the plant.
La comprensión de la mediana
Authors: Valenzuela-Ruiz Silvia M.
Published: March 2022

En este trabajo se realiza un análisis semiótico de la mediana. Basándonos en la clasificación de objetos primarios establecida en el Enfoque Ontosemiótico de la Investigación e Instrucción Matemática (Enfoque Ontosemiótico), consideramos útiles los problemas, con diferentes definiciones y propiedades, lenguaje asociado y algoritmos de cálculo. Con respecto a cada uno de estos puntos, resumimos las investigaciones didácticas que sugieren la existencia de frecuentes dificultades para trabajar con la media. Los intereses de elaborar este análisis se justifican por la inclusión en los planes de estudio, tanto de Educación Secundaria Obligatoria como de Bachillerato, del análisis exploratorio de datos, en los que el medio tiene un papel significativo. Además,
Protocolos de reabilitação após cirurgia cardíaca na fase hospitalar: uma revisão.
Authors: Toniollo Fernanda , Merino Daniela Faleiros Bertelli , Moreno Marlene Aparecida
Published: March 2022

Introdução: As doenças cardiovasculares são derivadas de fatores de risco tais como tabagismo, alcoolismo e desequilíbrio no perfil lipídico. A Organização Mundial da Saúde (OMS) constatou que cerca de 17 milhões de pessoas morrem por ano em decorrência de doenças relacionadas ao sistema cardiovascular. A cirurgia cardíaca é indicada em casos de infarto agudo do miocárdio, de valvopatias cardíacas, cardiopatias congênitas e transplante de coração. A reabilitação cardíaca consiste em atividades que visam garantir aos indivíduos cardiopatas, condições de melhora no âmbito físico, mental e social e deve ser realizada de forma multiprofissional, principalmente na fase hospitalar. Objetivo: Realizar uma revisão dos protocolos de reabilitação cardíaca na fase hospitalar no pós-operatório de cirurgias cardíacas em adultos. Metodologia: Levantamento bibliográfico nas plataformas PubMed, Scielo e Google Acadêmico. Foram incluídos no estudo pacientes adultos com cardiopatias que passaram por cirurgia de revascularização do miocárdio ou cirurgia de troca valvar, que deram início ao programa de reabilitação cardíaca em até 3 dias após a cirurgia, ainda no hospital. Resultados: 131 estudos foram selecionados, 119 não preencheram os critérios de inclusão. 12 artigos foram elegíveis, 07 foram descartados. Desta forma, foram incluídos nesta revisão 05 estudos. Conclusão: Concluiu-se que os protocolos mais usados na fase hospitalar da reabilitação cardíaca são os steps do Protocolo de Regenga, o cicloergômetro substituindo os exercícios aeróbicos convencionais, a utilização do CPAP durante as caminhadas e o uso da realidade virtual como aliada ao envolvimento do paciente à terapia.
Bright blue emissions on UV-excitation of LaBO3 (B=In, Ga, Al) perovskite structured phosphors for commercial solid-state lighting applications
Authors: Naveen Kumar B. V. , Samuel T. , Bevara Samatha , Ramachandra Rao K. , Chirauri Satya Kamal
Published: March 2022

Bright blue photoluminescence (PL) was obtained from Bi3+-activated LaBO3 (B = In, Ga, Al) perovskite nanophosphors. A cost-effective and low-temperature chemical route was employed for preparing Bi3+ doped LaBO3 (B=In, Ga, Al) which were then annealed at 1000 °C. The phase formation, morphological studies and luminescent properties of the as-prepared samples were performed by X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence and optical absorption spectroscopy. Comparison of emission intensities, lifetime studies, energy band gaps and color purity of all samples (pure and Bi3+ doped) were investigated for promising applications in UV light-emitting diodes, variable frequency drive (VFD), field emission display (FED), and other photoelectric fields.
On the possibility of obtaining the elastic and biocompatible film materials based on chitosan and N-succinyl chitosan
Authors: Bazunova Marina V. , Lazdin Roman Yu. , Elinson Mariya R. , Sharafutdinova Lucia A. , Mustakimov Robert A. , Kulish Elena I.
Published: March 2022

For the first time, the studies of polyhydric alcohols (glycerol, ethylene glycol and propylene glycol) impact on the structure, deformation–strength characteristics and hemocompatibility of the film materials based on chitosan and N-succinyl chitosan were carried out. It was shown that the introduction of polyhydric alcohols into molding solutions during the creation of the films based on chitosan and succinyl chitosan in the amount up to 0.05 mol/l is accompanied by the tensile elongation value increase by 2–2.5 times. The value of the breaking stress in this case decreases by 3–4 times. There is also a decrease in the overall surface roughness and a sharp drop in the elastic modulus of the films. The stabilizing impact of the systems based on chitosan and succinyl chitosan in the presence of glycerol and propylene glycol upon the cell membranes in physiological conditions allows inferring their high hemocompatibility.