bluuebunny/crossref_metadata_2025 huggingface dataset:
A Draft Chronological Biography of Seow Yeoh Thian (Part 2)
Authors: Fu Th'ng Bee
Published: November 2024

This study depicts a crucial decade in Seow Yeoh Thian’s life that had been accompanied with tremendous changes. When Pacific war broke out, not only he was forced to face the fall of his country and deaths of his bosom friends, but also inevitable discontinuity of his studies and great emotional catastrophe. Although war had brought him partings, Seow was left with no option but to move on. Similar to how Seow’s poems emphasized heavily on personal affairs instead of the public’s, this chronology focuses on the details of daily life during war time, therefore may seem lacking in traits of typical anti-war literatures. Seow’s poems have shown great interests on questioning human’s nature, alluding to present time’s issues with anecdotes of the past. The publication of Drafts of the Unstartling Words in such era; not only it is Seow’s last classical poetry publication in China mainland, but also marks the end of such poetry tradition. It was only the beginning of a dreary and ill-fated destiny. The history-changing event of 1949 brought him both political and cultural crisis, leaving him an destined dystopia. Due to his journey through Hong Kong and Malay Peninsula, Seow’s poetry vision had since relocated towards a farther and distant observation, with less enthusiasm and more pondering thoughts.
A Study on the Critical System of Zhang Ailing’s Novels
Authors: Zhongxuan Ji , Foo Ai Peng
Published: November 2024

Zhang Ailing is a very distinctive female writer in the modern and contemporary Chinese literary world. Through the survival track of the characters in her works, she shows us a deformed social style after the combination of Western modern civilization and Eastern declining culture, with unique cultural connotation. The academic circle began to study Eileen Zhang’s articles in the 1940s. This article uses time as the main line and sorted out the research overview of Eileen Zhang in different historical backgrounds and cultural atmospheres in China and the West. Through the combing of Eileen Zhang's research results, we can see that under a specific historical background, different academic research atmospheres and literary research concepts in China and the West have different perspectives and thoughts on the research of Eileen Chang’s articles.
Review Study on Sound Pattern in Mandarin as Second Language Learning
Authors: Ting Hie Ling , Sunarti S.
Published: November 2024

Sound pattern is a description of speech sound which including vowels pattern, consonants pattern, tone pattern etc. Studies on sound pattern of Mandarin was first conducted on Mandarin Dialect and it has extended to the field of Second Language Acquisition (SLA). China National Knowledge Infrastructure (CNKI) database were used to retrieve articles related to sound pattern in SLA. 81 articles published from year 2001-2021 were collected and analyzed. Descriptive analysis on research methodology, selection of respondents, topics covered in the study of SLA sound pattern were carried out in this study. Findings of this study show that three research methodology were utilized in the study of SLA sound pattern which are experimental phonetics, perceptual perception and mixed method. Majority of respondents were SLA learners from Asia, it is followed by Europe, Africa, America, and Oceania. Result of this study shows studies on vowels pattern was the major scope of sample studies, it is followed by tone pattern and consonants patterns. Characteristics of the studies on sound pattern were also included in this study. Thus, findings from this study provide a great insight for future research on sound patterns.
The Effect of TQM and Leadership on Organizational Performance of Dubai Police: The Mediating Role of Organizational Culture
Authors: Eshaq Muneer Dahif Allah Saeed , Zainol Zuraidah
Published: November 2024

The organization needs to evaluate the organizational performance on regular basis. Therefore, the main objective of the present study is to assess the relationship between Total Quality Management (TQM), leadership, organizational culture and organizational performance. Additionally, the mediating role of organizational culture is examined in this study. This study is quantitative in nature. Therefore, this research employs a cross-sectional design. The respondents of this study consist of Police employees working in Dubai. Furthermore, simple random sampling is adopted in the present study. 64.72% of the questionnaire distribution is received back from the respondents and used for analysis. This data is assessed through Smart PLS 3.3.2. The findings of the study reveal that all of the proposed hypotheses of the study are supported and the mediating role of organizational culture is also confirmed. Organizational culture has a significant positive effect on organizational performance. Moreover, the findings of this study are helpful for policymakers and academicians as the result implies that the adoption of TQM may improve performance and create a competitive advantage, thereby enhancing its contribution to economic development.
O PROCESSO DE LUTO E SUAS FORMAS NA ATUALIDADE: UM VIES PSICANALÍTICO
Authors: Bugari Hellen Rodrigues , Silva Juliana Áurea Barbosa , Lopes William Araujo
Published: November 2024

O luto, para a psicanálise, é um processo que marca um sofrimento pela perda de um objeto investido de afeto. A vivência deste luto pode ocorrer a partir de uma perda concreta, como a morte, ou de uma perda simbólica, de grande representação e significação para o sujeito. Neste sentido, os objetivos deste trabalho são apresentar as contribuições teóricas e conceituais de Sigmund Freud e Melanie Klein sobre o processo de luto, abordar os tipos de luto nas fases de desenvolvimento do sujeito, como infância, adolescência e vida adulta e, por fim, discutir sobre os lutos não reconhecidos na atualidade. A metodologia utilizada consiste em uma revisão bibliográfica, onde foram utilizados como base livros e artigos científicos publicados nos últimos anos, além de clássicos textos da teoria psicanalítica sobre o luto. Os resultados apresentam a definição do luto como um processo inerente à condição humana, na medida em que o sujeito se constitui na relação com o outro e com os objetos de afeto. Destacam-se, nesta discussão, as consequências do luto não vivenciado, como a possibilidade de desencadeamento de um estado depressivo. O estudo conclui que o luto não se restringe à morte, mas também comparece nas perdas simbólicas, como no término de relacionamentos, nas saídas de empregos e no envelhecer. Além disso, a pesquisa sublinha a importância de escutar os “lutos não reconhecidos” socialmente, como o luto pela perda do ideal da sexualidade e/ou pela perda de um animal de estimação.
Mourning, for psychoanalysis, is a process that marks suffering due to the loss of an object invested with affection. The experience of this mourning can occur from a concrete loss, such as death, or a symbolic loss of excellent representation and significance for the subject. In this sense, the objectives of this work are to present the theoretical and conceptual contributions of Sigmund Freud and Melanie Klein on the grieving process, address the types of mourning in the subject's developmental stages, such as childhood, adolescence, and adulthood, and finally, discuss current unrecognized grief. The methodology consists of a bibliographical review, where books and scientific articles published in recent years were used as a basis, as well as classic texts on psychoanalytic theory about mourning. The results present the definition of mourning as a process inherent to the human condition insofar as the subject is constituted in the relationship with others and with the objects of affection. In this discussion, the consequences of unexperienced grief stand out, such as the possibility of triggering a depressive state. The study concludes that grief is not restricted to death but also appears in symbolic losses, such as ending relationships, leaving jobs, and getting older. Furthermore, the research highlights the importance of listening to “unrecognized mourning” socially, such as mourning the loss of the ideal of sexuality and/or the loss of a pet.
Discrete Element Method Simulation of Filling Level in Planetary Ball Mill
Authors: Mhadhbi Mohsen , Avar Baris
Published: November 2024

In this study, DEM (discrete element method) was used to improve our understanding of the fundamental processes involved in the ball milling process, with a particular emphasis on the effect of the many different filling levels in planetary ball mills. This DEM methodology facilitates the simulation of the behavior of balls and powder particles inside the vials, enabling an understanding of the nature of the material milling and the structure of the flow. The major benefit of the DEM technique is the ability to incorporate interrelationships among different milling parameters. The simulations indicate that changing the filling level has a significant effect on the ball milling process.
Optimal Constant-Stress Accelerated Life Tests for the Marshall-Olkin Extended Lindley Distribution under Complete Sampling
Authors: Abu-Youssef S. E. , Sabry M. A. H. , Nasef M. R.
Published: November 2024

This study introduces an extended Lindley distribution utilizing a new family of Marshall-Olkin distributions, providing a more flexible framework for modeling lifetime data. The distribution is examined within the context of complete sampling for k-level constant stress accelerated life testing. A reliability analysis of the proposed model and a discussion on parameter estimation using maximum likelihood estimation are presented. Asymptotic confidence intervals for the parameters are derived through the Fisher information matrix. Bayesian estimation procedures and the Markov Chain Monte Carlo (MCMC) approach are also explored. Real data is analyzed to assess the model’s fit, followed by simulation studies to illustrate its performance. The paper concludes with a summary of findings and implications for future research.
Numerical Simulation and Analysis of the Duffing System using Python
Authors: Jani Joan
Published: November 2024

In this paper, we are presenting a numerical investigation of Duffing’s nonlinear system. The Duffing’s system is described by a nonlinear second-order differential equation, which shares he same structure like the damped and driven oscillator systems. The numerical integration of the system is done using Python scientific libraries such as NumPy and SciPy. The proposed technique is utilized to construct the bifurcation diagram and the Poincaré section and to analyze the behavior of the system by changing one parameter. This proposed method is characterized by versatility and the extrapolation of these numerical techniques and algorithms in the study of other nonlinear dynamical systems.
Prevalence and associated risk factors of Helicobacter pylori infection in community households in Lanzhou city
Authors: Zhou Ju-Kun , Zheng Ya , Wang Yu-Ping , Ji Rui
Published: November 2024

BACKGROUND

Helicobacter pylori (H. pylori ) infection exhibits a familial clustering phenomenon.

AIM

To investigate the prevalence of H. pylori infection, identify associated factors, and analyze patterns of transmission within families residing in the community.

METHODS

From July 2021 to September 2021, a total of 191 families (519 people) in two randomly chosen community health service centers in the Chengguan District of Lanzhou in Gansu Province, were recruited to fill out questionnaires and tested for H. pylori infection. Individuals were followed up again from April 2023 and June 2023 to test for H. pylori infection. The relationship between variables and H. pylori infection was analyzed using logistic regression and generalized linear mixed models.

RESULTS

In 2021, the individual-based H. pylori infection rate was found to be 47.0% (244/519), which decreased to 38.1% (177/464) in 2023. Additionally, the rate of individual-based H. pylori new infection was 22.8% (55/241). The family-based H. pylori infection rate in 2021 was 76.9% (147/191), which decreased to 67.1% (116/173) in 2023, and the rate of family-based H. pylori new infection was 38.6% (17/44). Individual H. pylori infection was positively correlated with age, body mass index (BMI), eating food that was excessively hot, frequent acid reflux, bloating, and halitosis symptoms, and negatively correlated with family size and nut consumption. New individual H. pylori infection was positively correlated with BMI, other types of family structures, drinking purified water, and frequent heartburn symptoms, while negatively correlated with the use of refrigerators and following a regular eating schedule. A larger living area was an independent protective factor for H. pylori infection in households. Frequently consuming excessively hot food and symptoms of halitosis were independent risk factors for H. pylori infection in individuals; frequent consumption of nuts was an independent protective factor for H. pylori infection. Other types of family structure, drinking purified water, and frequent heartburn symptoms were independent risk factors for new individual H. pylori infection; the use of a refrigerator was an independent protective factor for new H. pylori infections.

CONCLUSION

The household H. pylori infection rate in Lanzhou is relatively high and linked to socio-demographic factors and lifestyles. Eradication efforts and control of related risk factors are recommended in the general population.
Red harvester ants Pogonomyrmex barbatus (Smith, 1858) (Hymenoptera: Formicidae) do not distinguish between sorghum head mold symptomatic and asymptomatic seeds
Authors: Elliott-Vidaurri Lilly V. , Penn Hannah J. , Choudhury Robin A.
Published: November 2024

Red harvester ants, Pogonomyrmex barbatus (Smith, 1858) (Hymenoptera: Formicidae), common in the Lower Rio Grande Valley of Texas, are known to gather seeds from areas around their nests and store the seeds inside their nests for later consumption. As these ants often nest in and near agricultural fields, some of these seeds may be from crops and may also be infected with fungal plant pathogens. These pathogens can degrade seed coats and may cause the seeds to rot within the ant nests, decreasing storage time and potentially spreading the pathogen to other stored seeds. We studied how head mold, a common sorghum disease, changed ant preferences for sorghum seeds. Using seed depots, we evaluated foraging preferences for sorghum seeds with and without head mold and then monitored how many seeds of each type were collected by the colonies after 1, 2, 4, and 24 hours. We found that red harvester ants did not have any significant preference for infected or uninfected seeds, taking both equally over time. Given this non-preference, ants were assumed to be storing infected seeds next to uninfected seeds within their colonies. However, the risk that stored pathogen-infected seeds poses as a source of future seed infection to seeds within the nest and plants in the surrounding field needs to be further examined.
A Panel of Cultures of Cancer and Normal Lung Cells with a Characterized Expression of PD-L1 to Search and Development of the Target Modifiers of Immunotherapy
Authors: Bogush T. A. , Grishanina A. N. , Scherbakov A. M. , Khochenkov D. A. , Yunusova R. Yu. , Kalyuzhny S. A. , Kosorukov V. S.
Published: November 2024

Background. The search for eﬀective combinations of immune checkpoint inhibitors with common cytostatics, targeted cancer drugs and other treatments is a modern trend to improve the eﬀectiveness of immunotherapy.

Purpose. Development of a panel of lung cancer cell cultures and cells of normal lung tissue with a characterized molecular phenotype by expression of one of the targets of immunotherapy — programmed cell death ligand 1 (PD-L1).

Methods. PD-L1 expression was quantitatively analyzed by immunoﬂuorescence method associated with ﬂow cytometry.

Results. A panel of lung cancer cell cultures of diﬀerent histotypes and cells of normal lung tissue with characterized molecular phenotype was formed according to the expression of the immunotherapy target PD-L1. In terms of PD-L1 expression intensity, cell cultures can be arranged in a series: Calu-1  HFL-1  Calu-6  Wi-26  A-549  H-596  H-211, with a 7-fold diﬀerence in the index between Calu-1 and H-211.

Conclusion. The panel of cultures of cancer and normal lung cells is recommended for the search and development of eﬀective modiﬁers of the immunotherapy target PD-L1.
Dynamics of Matrix Metalloproteinase-9 Levels in the Novel Coronavirus Infection COVID-19
Authors: Sabitov A. U. , Khamanova Yu. B. , Moskaleva Yu. N. , Kamaev E. Yu. , Kuznetsov P. L. , Medvedeva M. D.
Published: November 2024

Background. It has been established that metalloproteinase-9 (hereinafter MMP-9) is the most inducible enzyme of the metalloproteinase family. It regulates the migration of leukocytes to the site of inflammation, participates in the stimulation of pro- and anti-inflammatory reactions and, thus, can act as an accessible biomarker of pulmonary matrix damage.

The aim of the study was to evaluate MPP-9 levels and their relationship with systemic immunity indicators in the novel coronavirus infection COVID-19 during treatment with various antiviral drugs.

Materials and methods. The study included patients aged 35–69 years (N=25) diagnosed with novel coronavirus infection COVID-19, hospitalized in the Infectious Diseases Inpatient Department of the State Autonomous Healthcare Institution of the Sverdlovsk Region City Clinical Hospital No. 40, Yekaterinburg, who were divided into two groups depending on antiviral therapy: group 1 (N=15) received favipiravir, group 2 (N=10) received riamilovir (trade name Triazavirin ®).

Results. There was a 2-fold reduction in the duration of dyspnea (P<0.05), catarrhal symptoms — by 2.7 times, fever — by 1.3 times (P<0.05) among patients receiving riamilovir compared to patients receiving favipiravir. Against the background of riamilovir therapy, there was a dynamic increase in the level of leukocytes and CD 3+ lymphocytes by 1.9 times (P<0.05) and an increase in the level of MMP-9 by 3 times (P<0.05) compared to the initial indicators. Correlations were found between the level of MMP-9 and a reduction in the duration of the following clinical manifestations: dyspnea (R=0.5, P<0.001), respiratory failure (R=0.4, P<0.001), fever (R=0.4, P<0.001), as well as the level of lymphocytes (R=0.6, P<0.001), CD 4+ and CD 3+ lymphocytes (R=0.6 (P<0.001) and R=0.7 (P<0.001), respectively).

Conclusions. A direct relationship between MMP-9 and clinical manifestations of the novel coronavirus infection COVID-19, as well as indicators of systemic immunity, has been established.
Efficacy, Immunogenicity, and Safety of the Combined Vector Vaccine Gam-COVID-Vac in Patients with Rheumatic Diseases
Authors: Kulikov A. N. , Muravyeva N. V. , Belov B. S. , Gridneva G. I. , Aronova E. S. , Verizhnikova Z. G. , Samarkina E. Yu.
Published: November 2024

The aim of the study is to assess the efficacy, immunogenicity, and safety of the combined vector vaccine Gam-COVID-Vac and to determine the risk factors for the development of adverse events (AEs) in patients with rheumatic diseases (RD).

Patients and methods. The present study consisted of a retrospective and prospective parts, which included 295 and 42 patients with RD, as well as 113 and 57 healthy controls, respectively. Information about efficacy was obtained from 291 patients with RD and 146 controls, which was assessed by the incidence of PCR-confirmed COVID-19 cases from 31 to 365 days after vaccination. The concentration of antibodies to SARS-CoV-2 was assessed by enzyme immunoassay in a prospective cohort at 1, 3, 6, and 12 months after administration of the second component of the vaccine. Safety was studied in all participants based on the incidence of AEs and exacerbation of underlying RD.

Results. After vaccination, 29 (9.97%) cases of COVID-19 were recorded in patients with RD, 27 of them were mild, and 2 required hospitalization, all cases ended in recovery. Treatment with rituximab before vaccination increased the risk of developing COVID-19 by 2.3 times. A sig-nificant increase in antibody titers was observed after 1, 3, and 12 months after full immunization in patients with RD (P<0.006 for all points). AEs were absent in 40.72% of patients with RD and 24.71% healthy controls, P<0.001. Exacerbations of RD were registered in 2 (0.6%) cases. The risk of developing local and systemic AEs (depending on the administered component) was increased in women, patients under the age of 60 year, with a duration of RD less than 10 years, and methotrexate therapy (P<0.016 for all cases).

Conclusions. According to the data obtained, the use of Gam-COVID-Vac in patients with RD is characterized by good efficacy, sufficient immunogenicity, and safety.
Antibacterial Therapy Options for Infections Caused by Carbapenem-Resistant Acinetobacter baumannii
Authors: Goncharova A. R. , Gostev V. V. , Goncharov N. E. , Kalinogorskaya O. S. , Gladyshev N. S.
Published: November 2024

The review presents current treatment regimens for infections associated with carbapenem-resistant Acinetobacter baumannii, which are leading nosocomial pathogens exhibiting multidrug resistance to available antibacterial drugs. To date, widely used beta-lactam antibiotics, including carbapenems, have lost their eﬀectiveness in combating acinetobacter infections, while new antibiotics remain poorly available to patients. Therefore, the only measure to combat the antibiotic resistance of carbapenem-resistant A. baumannii is to evaluate the eﬃciency of combination therapy in vitro and in vivo, which is of particular interest to Russian and foreign researchers.
Success of Succinates and Prospects for Their Use in Critical Conditions
Authors: Sviridov S. V. , Butrov A. V. , Afanasyev V. V. , Orlov Yu. P. , Petrov A. Yu.
Published: November 2024

To date, preparations containing succinic acid (succinate) are widely known to specialists working in intensive care. Several such preparations have gained wide acclaim among anesthesiologists and resuscitators, namely: Reamberin, infusion solution — a crystalloid preparation containing 1.5% meglumine sodium succinate; Remaxol, infusional solution – a complex infusional solution containing, in addition to succinic acid, nicotinamide, inosine, as well as the aliphatic α-amino acid methionine (which serves in the body as a donor of methyl groups in S-adenosyl-methionine during the biosynthesis of choline, adrenaline, etc., and is also a source of sulfur during the biosynthesis of cysteine); Cytoﬂavin, a solution for intravenous administration, containing a complex of two vital vitamins necessary to provide a pool of coenzymes — B2 in the form of a highly water-soluble form of riboﬂavin mononucleotide and PP in the form of nicotinic acid amide, succinic acid, and inosine (riboxin), as well as succinic acid itself. However, some skeptics have not been convinced yet, they oppose the use of these medications in the treatment of critical conditions. The purpose of this article is to expand our views on the natural essence of succinates, their biological role in the human body, highlighting the existing experience of their use in critical conditions, as well as the possibility of their use in the future.
THE EFFECT OF THE DIGITAL ECONOMY ON ECONOMIC GROWTH IN OUR REPUBLIC (IN AGRICULTURE)
Authors:   Dosent, Tashkent State Agrarian University, TSAU, Uzbekistan, Abdullayevna Karieva Gulnora , o‘g‘li Normurodov Sarvar Norboy ,   Assistant, Tashkent State Agrarian University, TSAU, Uzbekistan
Published: November 2024

Digitization of agriculture is one of the urgent tasks on the agenda, which will serve to ensure high economic growth in agriculture in the future. In general, the digital economy is the use of the results of analysis of processes and the processing of large volumes of data, which allows to significantly increase the efficiency of storage, sale and delivery of various productions, technologies, equipment, goods and services, information in digital form is the main A factor of production is a calculated activity.
Enantioselective regiospecific addition of propargyltrichlorosilane to aldehydes catalyzed by biisoquinoline N,N’-dioxide
Authors: Brako Noble , Narayanan Sreerag Moorkkannur , Burns Amber , Auter Layla , Cesiliano Valentino , Prabhakar Rajeev , Takenaka Norito
Published: November 2024

Distilled propargyltrichlorosilane with >99% isomeric purity was prepared for the first time, and its asymmetric catalytic regiospecific addition reaction to aldehydes was developed through a systematic catalyst structure–reactivity and selectivity relationship study. The observed catalyst structure–enantioselectivity relationship of the present allenylation reaction was found exactly opposite to that of the analogous allylation reaction. The method provided eleven α-allenic alcohols in 22–99% yield with 61:39–92:8 enantiomeric ratios. Furthermore, possible mechanisms of propargyl–allenyl isomerization of propargyltrichlorosilane were computationally investigated.
Electrochemical Synthesis of Cyclic Biaryl λ3-Bromanes from 2,2’-Dibromobiphenyls
Authors: Savkins Andrejs , Sokolovs Igors
Published: November 2024

The remarkable nucleofugality of diarylbromonium species renders them particularly suitable for generation of arynes for subsequent use in a wide range of synthetic applications. The common approach to generate cyclic biaryl λ3-bromanes is based on thermal decomposition of hazardous diazonium salts. Herein, we disclose a mild and straightforward approach to diarylbromonium species by direct anodic oxidation of 2,2'-dibromo-1,1'-biphenyl. The electrochemical method provides an access to a range of symmetrically and non-symmetrically substituted cyclic biaryl λ3-bromanes in moderate yields.
Percepción Ambiental de estudiantes universitarios del Centro Regional de Educación Superior Llano Largo, Acapulco, Guerrero
Authors: García Sánchez Silberio , Juárez Agis Alejandro , Uriostegui Santoyo Ruth Sayán , Utrilla Coello Rubí Guadalupe , Salome Branly Olivier , Torres Jacqueline Zeferino
Published: November 2024

La palabra ambiente tiene un significado diferente para cada persona, así también la percepción ambiental de cada individuo depende de muchos factores como la edad, educación y profesión, pero proporcionan información valiosa de la manera que observa su entorno. Es por ello, que el presente estudio tiene como objetivo conocer la percepción y actitud ambiental de los estudiantes de las cinco licenciaturas del Centro Regional de Estudios Superiores. Metodología: de tipo cuantitativo, descriptivo, transversal, no experimental, se aplicó una prueba paramétrica de Análisis de Varianza. Resultados: mostraron que los estudiantes percibieron el aspecto ambiental del campus positivo en todos sus aspectos, obteniendo los valores entre excelente, buena y aceptable (⁓60-70%), principalmente. Limitaciones: factor limitante de este estudio fue la falta de acceso de algunos directores de escuelas. Valor: evidenciar que se promueven la conservación del ambiente y que fomentan en los estudiantes una conciencia ambiental con responsabilidad, cambiando sus actitudes hacia una sociedad enfocada en un desarrollo sostenible. Conclusiones: es necesario mejorar las estrategias que ayuden a fortalecer la cultura ambiental entre los universitarios de todas las carreras.
Optimization Employee Performance Through Role Work Life Balance And Work Environment
Authors: Fikri Muchammad , Wahyu Utomo Kabul , Hidayah Zainur
Published: November 2024

This study aims to analyze the influence of work-life balance and work environment on employee performance, with job satisfaction and organizational commitment as intervening variables. Data collection in this study was conducted through a survey approach with a descriptive quantitative research type, by distributing questionnaires to 103 respondents. The data analysis tool used in this study is SmartPLS 4.0. The results of this study indicate that, partially, work-life balance and job satisfaction have a positive and significant effect on performance. Partially, the work environment and organizational commitment have a positive but not significant effect on performance. Partially, work-life balance and work environment have a positive and significant effect on job satisfaction. Work-life balance has a positive but not significant effect on organizational commitment. The work environment has a positive and significant effect on organizational commitment. Job satisfaction mediates the effect of work-life balance on performance and the effect of the work environment on performance. Organizational commitment does not mediate the effect of work-life balance on performance nor the effect of the work environment on performance.
 
Keyword: Work Life Balance, Work Environment, Job Satisfaction, Organizational Commitment, Employee Performance
Safety and Efficacy of a Developed ‘Patent Ductus Arteriosus Occluder Device’: A Porcine Model Analysis Over Multiple Time Points
Authors: Kumar Minocha  Pramod , Deveshkumar Kothwala , Kamna Pandya , Rana Nirav Mistry Saurabh , Rahul Sharma
Published: November 2024

This study assessed the safety and performance of a patent ductus arteriosus (PDA) occluder using a porcine carotid artery model involving three male pigs. Each pig underwent a thorough physical examination and met the criteria for stable health and body weight. On day 0, the occluder was implanted under proper analgesia and anesthesia, with heparin used to prevent clot formation. The deployment process was meticulously evaluated through angiography and Quantitative Vascular Analysis (QVA) before and after implantation. Arteries were harvested at 90, 180, and 365 days for histopathological analysis. The occluder fulfilled all acceptance criteria, demonstrating successful deployment, trackability, and no cranial artery flow above the device. Gross necropsy showed a bulged carotid artery, suggesting a reaction to the device, while histopathological evaluations showed good endothelialization at all time points. The occluder was well-visualized during imaging, deployed easily, and could be withdrawn without issue. It effectively occluded the artery at all follow-ups without migrating from the target site. All animals survived the procedure and post- procedural period with the device intact. These results suggest that the PDA occluder is safe and effective in this model, showing promise for future human clinical applications, though further studies are needed to confirm long-term safety and efficacy.
Novel Self-Expandable Laser-Cut Device for Effective Thrombus Retrieval: Overcoming Limitations in Thrombectomy for Deep Vein Thrombosis, Peripheral Artery Disease and Pulmonary Embolism
Authors: Deveshkumar Kothwala , Niravkumar Maheshbhai Rana , Maheshbhai Niravkumar
Published: November 2024

Pulmonary embolism (PE) is a serious complication of deep vein thrombosis (DVT) and peripheral artery disease, often leading to fatal outcomes. The first line of treatment for DVT and PAD is anticoagulation: preventing the thrombus, occlusion of blood vessels, and propagation of PE especially in the case of DVT where limb or life-threatening complications are at risk. Clots retrieved from vessels include mechanical and manual interventions such as catheter-directed thrombolysis and thrombectomy. Yet the risks involved with thrombotic and embolic vascular occlusions are high because they cause occlusion of blood flow in crucial vessels; this may lead to tissue damage, organ failure, and death. Most of the existing thrombectomy devices do not remove the organized thrombus completely while prevention of clot fragmentation is also lacking. The study presents a new, self-expanding laser-cut clot retrieval device specifically designed to remove both hard and soft thrombi with no trauma at all to the vessel wall. This is one of the promising advancements in thrombectomy that overcomes the disadvantages of other existing technologies and offers a stronger approach for the removal of occlusions in the vascular system associated with DVT, PAD, and PE. The simulation test in vitro and a trackability test have been conducted with the developed device together with its delivery system for validation. These tests were envisaged to demonstrate how the device can operate, for example, navigate through the vasculature, and retrieve thrombi safely and accurately.
The Role of Immunotherapy in ALL and its Impact on Healthcare
Authors: Amir Mahin
Published: November 2024

Background ALL is a rare but aggressive malignant cancer caused by uncontrolled proliferation of lymphoblasts which disrupt normal organ function.  Review of Interventions In this article we will discuss how genomic medicine allows better risk stratification and early identification of certain genetic alterations. Different immunotherapies will be reviewed, their mechanism of action and novel upcoming therapies.  Assessment of Impact The addition of immunotherapy has improved clinical outcomes for patients, increasing overall survival and having a lower AE profile.  Conclusion Immunotherapy offers a more targeted approach in ALL management, despite high initial costs, it can prove to be cost-effective and inevitably reduce burden on a health system.
Cómo producir gas combustible con pulpa de café
Authors: Calle Velez Hernán
Published: November 2024

Una de las formas, tal vez más sencillas, de utilización de la pulpa, además de su empleo como fertilizante, es la obtención de biogás. La planta de producción de gas metano es básicamente una cámara cerrada donde se almacenan los desperdicios para su fermentación. Esta planta puede ser de ladrillo revestido con cemento, de lámina de hierro o de materiales similares. Se dan las especificaciones necesarias para la construcción e instalación de una planta de tipo metálico. Los mayores rendimientos se obtienen cuando se carga la planta cada 40 días de desperdicios y cuando existe una temperatura interna de 25° en promedio. La planta construída en Cenicafé produce gas suficiente para mantener en ebullición 4 litros de agua durante 5 horas diarias en promedio.
Fisiología del Café Resúmenes
Authors: Valencia Aristizabal German , Maya Montalvo Luis
Published: November 2024

Obra de información bibliográfica con 1.196 resúmenes distribuídos en los temas de: 1. Abonos. 2. Almacenamiento. 3. Bioquímica. 4. Calidad de la bebida. 5. Comercialización. 6. Composición química. 7. Costos y rendimientos. 8. Efectos fisiológicos de la bebida. 9. Factores ambientales. 10. Fertilización y producción. 11. Fisiología. 12. Métodos de análisis. 13. Morfología. 14. Nutrición mineral. 15. Prácticas culturales. 16. Procesamiento. 17. Producción. 18. Semillas. 19. Subproductos. Se complementa la publicación con índices de: publicaciónes analizadas, materias relacionadas, descriptores y autores.
Periodic Gamma-Ray Modulation of the Blazar PG 1553+113 Confirmed by Fermi-LAT and Multiwavelength Observations
Authors: Abdollahi S. , Baldini L. , Barbiellini G. , Bellazzini R. , Berenji B. , Bissaldi E. , Blandford R. D. , Bonino R. , Bruel P. , Buson S. , Cameron R. A. , Caraveo P. A. , Casaburo F. , Cavazzuti E. , Cheung C. C. , Chiaro G. , Ciprini S. , Cozzolongo G. , Cristarella Orestano P. , Cutini S. , D’Ammando F. , Di Lalla N. , Dirirsa F. , Di Venere L. , Domínguez A. , Fegan S. J. , Ferrara E. C. , Fiori A. , Fukazawa Y. , Funk S. , Fusco P. , Gargano F. , Garrappa S. , Gasparrini D. , Germani S. , Giglietto N. , Giordano F. , Giroletti M. , Green D. , Grenier I. A. , Guiriec S. , Hays E. , Horan D. , Kuss M. , Larsson S. , Laurenti M. , Li J. , Liodakis I. , Longo F. , Loparco F. , Lott B. , Lovellette M. N. , Lubrano P. , Maldera S. , Malyshev D. , Manfreda A. , Marcotulli L. , Martí-Devesa G. , Mazziotta M. N. , Mereu I. , Michelson P. F. , Mitthumsiri W. , Mizuno T. , Monzani M. E. , Morselli A. , Moskalenko I. V. , Negro M. , Omodei N. , Orienti M. , Orlando E. , Ormes J. F. , Paneque D. , Perri M. , Persic M. , Pesce-Rollins M. , Porter T. A. , Principe G. , Rainò S. , Rando R. , Rani B. , Razzano M. , Reimer A. , Reimer O. , Saz Parkinson P. M. , Scotton L. , Serini D. , Sesana A. , Sgrò C. , Siskind E. J. , Spandre G. , Spinelli P. , Suson D. J. , Tajima H. , Takahashi M. N. , Tak D. , Thayer J. B. , Thompson D. J. , Torres D. F. , Valverde J. , Verrecchia F. , Zaharijas G.
Published: November 2024

A 2.1 yr periodic oscillation of the gamma-ray flux from the blazar PG 1553+113 has previously been tentatively identified in ∼7 yr of data from the Fermi Large Area Telescope. After 15 yr of Fermi sky-survey observations, doubling the total time range, we report >7 cycle gamma-ray modulation with an estimated significance of 4σ against stochastic red noise. Independent determinations of oscillation period and phase in the earlier and the new data are in close agreement (chance probability <0.01). Pulse timing over the full light curve is also consistent with a coherent periodicity. Multiwavelength new data from Swift X-Ray Telescope, Burst Alert Telescope, and UVOT, and from KAIT, Catalina Sky Survey, All-Sky Automated Survey for Supernovae, and Owens Valley Radio Observatory ground-based observatories as well as archival Rossi X-Ray Timing Explorer satellite-All Sky Monitor data, published optical data of Tuorla, and optical historical Harvard plates data are included in our work. Optical and radio light curves show clear correlations with the gamma-ray modulation, possibly with a nonconstant time lag for the radio flux. We interpret the gamma-ray periodicity as possibly arising from a pulsational accretion flow in a sub-parsec binary supermassive black hole system of elevated mass ratio, with orbital modulation of the supplied material and energy in the jet. Other astrophysical scenarios introduced include instabilities, disk and jet precession, rotation or nutation, and perturbations by massive stars or intermediate-mass black holes in polar orbit.
Revealing the Elusive Companion of the Red Giant Binary 2MASS J05215658+4359220 from UV HST and Astrosat/UVIT Data
Authors: Bianchi Luciana , Hutchings John , Bohlin Ralph , Thilker David , Berti Emanuele
Published: November 2024

Black hole (BH) demographics in different environments is critical in view of recent results on massive star binarity, and of the multimessenger detectability of compact object mergers. But the identification and characterization of noninteracting BHs are elusive, especially in the sparse field stellar population. A candidate noninteractive BH + red giant (RG) binary system, 2MASS J05215658+4359220, was identified by T. A. Thompson et al. We obtained Astrosat/UVIT far-ultraviolet (FUV) imaging and Hubble Space Telescope (HST) UV−optical imaging and spectroscopy of the source to test possible scenarios for the optically elusive companion. HST/STIS spectra from ≈1600 to 10230 Å are best fit by the combination of two stellar sources, a RG with T
eff = 4250 ± 150 K, log g = 2.0, R
RG ∼ 27.8 R
⊙ (assuming a single-temperature atmosphere), and a subgiant companion with T
eff = 6000 K, R
comp = 2.7 R
⊙, or T
eff = 5270 K, R
comp = 4.2 R
⊙ using models with one-tenth or one-third solar metallicity, respectively, log g = 3.0, extinction E

B−V
= 0.50 ± 0.2, adopting the Data Release 3 Gaia distance D = 2463 ± 120 pc. No FUV data existed prior to our programs. STIS spectra give an upper limit of 10−17 erg cm−2 s−1 Å−1 shortwards of 2300 Å; an upper limit of ≳25.7 ABmag was obtained in two UVIT FUV broad bands. The nondetection of FUV flux rules out a compact companion such as a hot white dwarf. The STIS spectrum shows strong Mg ii
λ2800 Å emission, typical of chromospherically active RGs. The masses inferred by comparison with evolutionary tracks, ∼1M
⊙ for the RG and between 1.1 and 1.6 M
⊙ for the subgiant companion, suggest past mass transfer, although the RG currently does not fill its Roche lobe. WFC3 imaging in F218W, F275W, F336W, F475W, and F606W shows an unresolved source in all filters.
Photometric and Spectroscopic Analysis of Eight Totally Eclipsing Contact Binaries with Small Mass Ratios
Authors: Wang Li-Heng , Li Kai , Guo Ya-Ni , Wang Jing-Yi , Gao Xiang , Gao Xing , Sun Guo-You
Published: November 2024

This paper selected eight totally eclipsing contact binaries for photometric and spectroscopic studies. Spectral data were analyzed by University of Lyon Spectroscopic analysis Software, and photometric data were analyzed using PHOEBE through Markov Chain Monte Carlo (MCMC) sampling. We used two methods to calculate the initial values for running MCMC: one method is a new approach proposed by ourselves to model light curves without spots, while the other method is the genetic algorithm, which can determine physical parameters with spots. The results imply that these eight targets are all contact binary stars with a small mass ratio below 0.25. There are four systems exhibiting the O’Connell effect. By adding a dark spot on the primary component, the ideal fitting can be obtained. Meanwhile, it was found that two systems are shallow contact binaries, while the remaining six are moderate contact binaries. An O − C analysis of the eight eclipsing binary stars revealed that seven of them exhibit long-term changes. Four of them display a long-term decreasing trend in orbital period, while the other three show a long-term increasing trend, and two targets exhibit periodic variations. A decrease in period may be caused by the transfer of matter from the more massive component to the less massive component, while an increase in period may be caused by transfer in the opposite way. The absolute physical parameters, orbital angular momentum, initial masses, and ages of these eight systems were calculated. Additionally, their mass–luminosity and mass–radius distributions were analyzed.
Constraining the Low-mass End of the Stellar-to-halo Mass Relation with Surveys of Satellite Galaxies
Authors: Monzon J. Sebastian , van den Bosch Frank C. , Mitra Kaustav
Published: November 2024

The abundance of satellite galaxies is set by the hierarchical assembly of their host halo. We leverage this to investigate the low-mass end (M
H < 1011
M
⊙) of the stellar-to-halo mass relation (SHMR), which is key to constraining theories of galaxy formation and cosmology. We argue that recent analyses of satellite galaxies in the Local Group environment have not adequately modeled the dominant source of scatter in satellite stellar mass functions: the variance in accretion histories for a fixed host halo mass. We present a novel inference framework that not only properly accounts for this halo-to-halo variance but also naturally identifies the amount of host halo mass mixing, which is generally unknown. Specifically, we use the semianalytical SatGen model to construct mock satellite galaxy populations consistent with the third data release of the Satellites Around Galactic Analogs survey. We demonstrate that even under the most idealized circumstances, the halo-to-halo variance makes it virtually impossible to put any meaningful constraints on the scatter in the SHMR. Even a satellite galaxy survey made up 100 hosts can at best only place an upper limit of ∼0.5 dex on the scatter (at the 95% confidence level). This is because the large variance in halo assembly histories dominates over the scatter in the SHMR. This problem can be overcome by increasing the sample size of the survey by an order of magnitude (∼1000 host galaxies), something that should be fairly straightforward with forthcoming spectroscopic surveys.
Expanding the Inventory of Molecule-rich Planetary Nebulae: New Observations of M4-17, Hu 1-1, M1-59, and Na 2
Authors: Gold K. R. , Schmidt D. R. , Ziurys L. M.
Published: November 2024

Molecular observations of four planetary nebulae (PNe), M4-17, Hu 1-1, M1-59, and Na 2, were conducted at 1–3 mm using the Arizona Radio Observatory’s 12 m antenna and Submillimeter Telescope, and the Institut de Radioastronomie Millimétrique 30 m Telescope. Toward M4-17, HNC (J = 3 → 2), CCH (N = 2 → 1, N = 3 → 2), CN (N = 1 → 0, N = 2 → 1), H2CO (J
Ka,Kc = 21,2 → 11,1, J
Ka,Kc = 20,2 → 10,1, J
Ka,Kc = 21,1 → 11,0), CS (J = 3 → 2, J = 5 → 4), and H13CN (J = 2 → 1) were detected. An almost identical set of transitions was identified toward Hu 1-1. Moreover, c–C3H2 was detected in Hu 1-1 via three 2 mm lines: J
Ka,Kc = 31,2 → 22,1, J
Ka,Kc = 41,4 → 30,3, and J
Ka,Kc = 32, 2 → 21,1. HNC, CCH, CN, CS, and H13CN were found in M1-59, as well as H2S via its J
Ka,Kc = 11,0 → 10,1 line—the first detection of this key sulfur species in PNe. In addition, CCH and CN were identified in the 27,000 yr old Na 2. Among these four sources, CN and CCH were the most prevalent molecules (after CO and H2) with fractional abundances, relative to H2, of f ∼ 0.9–7.5 × 10−7 and 0.8–7.5 × 10−7, respectively. CS and HNC have abundances in the range f ∼ 0.5–5 × 10−8, the latter resulting in HCN/HNC ∼ 3 across all three PNe. The unusual species H2CO, c–C3H2, and H2S had f ∼ 3–4 × 10−7, 10−8, and 6 × 10−8. This study suggests that elliptical PNe such as Hu 1-1 can have a diverse molecular composition. The presence of CN, CCH, and HCO+ in Na 2, with comparable abundances to younger PNe, demonstrates that molecular content is maintained into the late PN stage.
Between the Extremes: A JWST Spectroscopic Benchmark for High-redshift Galaxies Using ∼500 Confirmed Sources at z ≥ 5
Authors: Roberts-Borsani Guido , Treu Tommaso , Shapley Alice , Fontana Adriano , Pentericci Laura , Castellano Marco , Morishita Takahiro , Bergamini Pietro , Rosati Piero
Published: November 2024

The exceptional spectra of the most luminous z > 10 sources observed so far have challenged our understanding of early galaxy evolution, requiring a new observational benchmark for meaningful interpretation. As such, we construct spectroscopic templates representative of high-redshift, star-forming populations, using 482 confirmed sources at z = 5.0−12.9 with JWST/NIRSpec prism observations, and report on their average properties. We find z = 5−11 galaxies are dominated by blue UV continuum slopes (β = −2.3 to −2.7) and reduced Balmer indices, characteristic of dust-poor and young systems, with a shift towards bluer slopes and younger ages with redshift. The evolution is mirrored by ubiquitous C iii] detections across all redshifts (rest-frame equivalent widths of 5−14 Å), which increase in strength towards early times. Rest-frame optical lines reveal elevated ratios (O32 = 7–31, R23 = 5–8, and Ne3O2 = 1−2) and subsolar metallicities (log(O/H) = 7.3−7.9), typical of ionization conditions and metallicities rarely observed in z ∼ 0 populations. Within our sample, we identify 57 Lyα emitters, which we stack and compare to a matched sample of nonemitters. The former are characterized by more extreme ionizing conditions with enhanced C iii], C iv, and He ii + [O iii] line emission, younger stellar populations from Balmer jumps, and a more pristine interstellar medium seen through bluer UV slopes and elevated rest-frame optical line ratios. The novel comparison illustrates important intrinsic differences between the two populations, with implications for Lyα visibility. The spectral templates derived here represent a new observational benchmark with which to interpret high-redshift sources, lifting our constraints on their global properties to unprecedented heights and extending out to the earliest of cosmic times.