bluuebunny/crossref_metadata_2025 huggingface dataset:
Image-based Phenotyping Identifies Quantitative Trait Loci for Cluster Compactness in Grape
Authors: Underhill Anna , Hirsch Cory , Clark Matthew
Published: September 2020

Grape (Vitis vinifera) cluster compactness is an important trait due to its effect on disease susceptibility, but visual evaluation of compactness relies on human judgement and an ordinal scale that is not appropriate for all populations. We developed an image analysis pipeline and used it to quantify cluster compactness traits in a segregating hybrid wine grape (Vitis sp.) population for 2 years. Images were collected from grape clusters immediately after harvest, segmented by color, and analyzed using a custom script. Both automated and conventional phenotyping methods were used, and comparisons were made between each method. A partial least squares (PLS) model was constructed to evaluate the prediction of physical cluster compactness using image-derived measurements. Quantitative trait loci (QTL) on chromosomes 4, 9, 12, 16, and 17 were associated with both image-derived and conventionally phenotyped traits within years, which demonstrated the ability of image-derived traits to identify loci related to cluster morphology and cluster compactness. QTL for 20-berry weight were observed between years on chromosomes 11 and 17. Additionally, the automated method of cluster length measurement was highly accurate, with a deviation of less than 10 mm (r = 0.95) compared with measurements obtained with a hand caliper. A remaining challenge is the utilization of color-based image segmentation in a population that segregates for fruit color, which leads to difficulty in differentiating the stem from the fruit when the two are similarly colored in non-noir fruit. Overall, this research demonstrates the validity of image-based phenotyping for quantifying cluster compactness and for identifying QTL for the advancement of grape breeding efforts.
The impact of smartphone advergames characteristics on purchasing intentions: the mediating role of game involvement
Authors: K. Al-Soluiman Rana , Q. Bataineh Abdallah , M. Al-Jabaly Sameer , A. Salhab Hanadi
Published: September 2020

This research aimed to investigate the impact of smartphone advergames characteristics on purchasing intentions. Four dimensions were considered (irritation, entertainment, credibility, and informativeness). To achieve this aim, the researchers developed a model based on literature reviews and previous studies; a self-administrated questionnaire was designed and distributed over a convenience sample. The researchers used a quantitative method and a descriptive-analytical approach; the study sample consisted of 600 consumers, and 519 questionnaires were returned with an 86.5% response rate. Various statistical methods, including descriptive, simple linear regression, were used to analyze the data and test the hypotheses. This research’s key findings were that there is a statistically direct impact of irritation, entertainment, credibility, and informativeness on consumers’ purchasing intentions. Moreover, there is a mediating role of game involvement between advergames and consumers’ purchasing intentions. Hence, many Jordanian companies can use smartphone mobile advertising to increase sales and create product brand image among consumers. Smartphone advergaming provides numerous opportunities and challenges for advertisers in the current dynamic business environment.
AcknowledgmentThe authors are grateful to the Middle East University, Amman, Jordan, for the full financial support granted to this research project.
Comparing Cost Leadership Strategy with Differentiation Strategy towards Firm Performance on Jakarta Islamic Index
Authors: Surono Surono , Suryanto Tulus , Anggraini Erike
Published: September 2020

The research aimed to examine the effect of cost leadership strategy and differentiation strategy on company’s performance. It was conducted in companies listed in the Jakarta Islamic Index from 2014 to 2018. Purposive sampling was used to obtain samples from 12 companies. Analysis was done by multiple linear regression with the help of the IBM SPSS 23 statistical program for windows with a quantitative descriptive approach. The results show that the cost leadership strategy influences company’s performance compared to differentiation strategy. The implementation of a low-cost strategy is significantly relevant to the condition of people who are sensitive to price and are not much aware about brand products in decision making. The design of a unique item model does not determine success in marketing a product, the relative price offered is quite high and only in certain market segments the product is of public interest. Product quality is defeated by the quantity of goods, people prefer how much goods are obtained than the durability of the products consumed.
Capacidade de uso das terras da Serra da Jiboia-Bahia
Authors: Cassamo Manuel Júlio , Vinhas Costa Oldair Del’Arco , Gloaguen. Thomas Vicent , Poelking. Everton Luís , Santana Pinheiro Emmanuel Reinan
Published: September 2020

A Serra da Jiboia é um importante maciço serrano que apresenta áreas significativas recobertas por remanescente de Mata Atlântica na região do Recôncavo da Bahia. O objetivo do trabalho é caracterizar o meio físico da área e identificar os domínios pedológicos, visando correlacioná-los à capacidade de uso atual das terras, subsidiando o planejamento de uso e ocupação. Os resultados demonstram que o ambiente apresenta fortes limitações à prática de atividades agropecuárias e/ou ocupação humana. Com base na interpretação da capacidade de uso das terras, restou demonstrado que, na Serra da Jiboia, as terras são mais apropriadas à manutenção da vegetação nativa, à proteção da flora e fauna silvestre, bem como para a recarga de aquíferos que abastecem a região.
O planejamento regional francês em meados do século XX: o impacto da obra de Jean-François Gravier
Authors: Pedrosa Breno Viotto
Published: September 2020

Este artigo apresenta o contexto de publicação e as ideias centrais da obra Paris et le désert français de Jean-François Gravier. A concepção central dessa obra – e de outras publicadas pelo autor – auxiliaram a formar um consenso dentro do campo do planejamento regional, admitindo que a desconcentração urbano-industrial é uma medida salutar para o funcionamento da economia nacional, dirimindo desigualdades econômicas e o risco de colapso da unidade nacional. Além disso, exploramos as consequências de suas ideias para a prática do planejamento, ou seja, até que ponto suas ideias se converteram em políticas públicas.
Erratum: Erythropoietin Gene Polymorphism rs551238 is Associated with a Reduced Susceptibility to Brain Injury in Preterm Infants
Authors: Ye Xiufeng , Chen Guangfu
Published: September 2020

Dr. Xiufeng Ye and Dr. Guangfu Chen are both co-corresponding authors.

Accordingly, please make the following two corrections to the paper:

1) Add * to the author Xiufeng Ye.

2) *Address correspondence to Dr. Chen guangfu, szchengf@email.szu.edu.cn or Dr. Xiufeng Ye, szrosexiu@
126.com, Shenzhen Second People’s Hospital, 3002, Sungang West Road, Shenzhen 518035,
China.
Neonatal Hyperbilirubinemia: An Updated Appraisal of National Guidelines
Authors: Capasso Letizia , Palma Marta , Coppola Clara , Salomè Serena , Esposito Valentina , Grappone Lidia , Raimondi Francesco
Published: September 2020

Recent reports from several developed countries have documented a resurgence of bilirubin
encephalopathy causing both healthcare and forensic issues. For these reasons, many national
pediatric societies have issued recommendations on the diagnosis and the treatment of clinically
significant neonatal hyperbilirubinemia. The differences among individual national documents may
have an impact on neonatal healthcare. This paper shortly reviews the advantages and the shortcomings
of the main international guidelines with a focus on the available evidence.
An Alternative Classification Scheme for Accessory Mental Foramen
Authors: Yalcin Turgut Yagmur , Bektaş-Kayhan ıvanc , Yilmaz Ayca , Ozcan Ilknur
Published: September 2020

Background:

The mental foramen (MF) is an important anatomical landmark on the
mandible. MFs may occur singly or with extra foramina (accessory mental foramen (AMF)).

Objective:

The aim of the present study was to discuss the importance of recognition and classification
of AMFs.

Methods:

This study assessed CBCT images of 593 patients (208 male, 385 female) and proposed
an AMF classification scheme based on three different characteristics: (1) location of the AMF
with respect to the MF; (2) relationship of AMFs with tooth apices; and (3) origin of the AMF. The
chi-squared test was used to compare the qualitative data as well as descriptive statistical methods
when the study data were evaluated. Significance was assessed at the p<0.05 level.

Results:

A total of 80 AMFs were found in 71 patients. Six cases involved bilateral AMFs,
whereas three cases showed double AMFs. The most common AMF location was the region posterior
of the MF. Notably, all the AMFs detected in line with the mesial half of the first molar were
present in female patients. Based on AMF origins, 44.5%, 48.6%, and 6.7% of the AMFs were categorized
as type I, type II, and a new category identified in this study, type III.

Conclusion:

This study revealed that some foramina locations were not considered in the previous
classification. Recognition and identification of these foramina might be critical to prevent possible
complications. The proposed classification scheme may facilitate this objective and can be a new
focus for future studies.
Guiding Lineage Specific Differentiation of SHED for Target Tissue/Organ Regeneration
Authors: Han Yuanyuan , Zhang Lili , Zhang Chengfei , Dissanayaka Waruna L.
Published: September 2020

Stem cells from Human Exfoliated Deciduous teeth (SHED) are considered one of the
most attractive cell sources for tissue engineering due to their easy acquisition with no donor morbidity,
ready availability, ability to self-renew with high proliferation, capacity for multilineage differentiation
and immunomodulatory functions. To date, SHED are able to differentiate into odonto-/
osteoblasts, neuronal cells, endothelial cells, hepatocyte-like cells, chondrocytes, epidermal
cells among many other cell types. Accordingly, SHED possess a promising potential to be used in
the cell-based therapy for various diseases, including reversible pulpitis, orofacial bone defects,
neurodevelopmental disease and ischemic injury. Despite this potential, it has been a concern that
tissue specific stem cells do not differentiate with the same efficacy into all the different lineages
as they may have an inherent tendency to differentiate toward the tissues from which they were
originally derived. Furthermore, stem cell niche comprises of a complex microenvironment where
various cells, soluble signals, extracellular matrix and physical cues interplay to maintain the stemness
of SHED and modulate their differentiation. Therefore, it is of significant importance to identify
the specific microenvironmental cues that regulate lineage specific differentiation of SHED,
which could inspire to develop functional approaches in target tissue regeneration. In this review,
we highlight the recent studies that demonstrated multilineage differentiation capacity of SHED, focusing
on how the microenvironment could be modified using different cues in order to achieve tissue
specific regeneration.
Anticancer Potential of Lepidium Sativum Seeds Aqueous Extract on the Azoxymethane/ Dextran Sulfate Sodium-Induced Colon Cancer In vivo
Authors: Hussien Nahed Ahmed , Alsulami Ghazwaa Awad
Published: September 2020

Background::

Colon cancer is responsible for increasing the death rate worldwide. Commonly used anticancer drugs have various side effects and their clinical usage must be restricted due to their toxicity.

Objective::

The present research aimed to evaluate the anticancer potential of Lepidium sativum L. (LS) seeds aqueous extract against azoxymethane/dextran sodium sulfate (AOM/DSS) inducedcolon cancer in male albino mice.

Methods::

Low (200 mg/kg) and high (400 mg/kg) doses of LS seeds extract were used to treat induced colon cancer in different stages.

Results::

The present results report that LS treatment for mice with colon cancer especially in high dose, decreases colon polyps/tumor incidence and size, tissues disorder, expression of P53 and increases apoptosis in colon tissue. Moreover, LS decreases micronucleus induction in polychromatic (PCE), increases PCE/normochromatic erythrocytes ratio and decreases the percentage of sperm abnormalities.

Conclusion::

The present study reports anticancer potential of LS for induced colorectal cancer mice by ameliorating the inflammatory steps of colon.
Computing Salient Feature Points of 3D Model Based on Geodesic Distance and Decision Graph Clustering
Authors: Sun Dechao , Chen Nenglun , Wang Renfang , Liu Bangquan , Liang Feng
Published: September 2020

Introduction::

Computing salient feature points (SFP) of 3D models has important application value in the field of computer graphics. In order to extract more effectively, a novel SFP computing algorithm based on geodesic distance and decision graph clustering is proposed.

Method::

Firstly, geodesic distance of model vertices is calculated based on heat conduction equation, then average geodesic distance and importance weight of vertices are calculated. Finally, decision graph clustering method is used to calculate the decision graph of model vertices.

Result and Discussion::

3D models in SHREC 2011 dataset are selected to test the proposed algorithm. Compared with the existing algorithms, this method calculates the SFP of the 3D model from a global perspective. Results show that it is not affected by model posture and noise.

Conclusion::

Our method maps the SFP of 3D model to 2D decision-making diagram, which simplifies the calculation process of SFP, improves the calculation accuracy and has strong robustness.
Assessment of Risks for Successful Implementation of Industry 4.0
Authors: Gadekar Rimalini , Sarkar Bijan , Gadekar Ashish
Published: September 2020

Purpose:

The transformation happening globally, though referred to by different names
and nomenclatures, the overall objective to inspire digitalization and smart practices by reducing
human intervention and enhancing machine intelligence to take on the global manufacturing and
production to another level of excellence is a proven fact now. However, earlier research has been
found lacking in the strategic approach to evaluate and analyze the I4.0 adoption-related risks for its
implementation. This ultimately deprived organizations of a multitude of the benefits of I4.0 adoption.
This research proposes a systematic methodology for understanding and evaluating the most
evident risks in the context of I4.0 implementation.

Design/Methodology/Approach:

The research is mainly based on the inputs from experts/consultants
along with robust literature review and researcher’s experience in the area of risk handling. The
MCDM methods used for investigation and assessment are Fuzzy AHP and Fuzzy TOPSIS. The
outcomes of the study are further validated through sensitivity analysis and real-world scenario.

Results:

Technical and Information Technology (IT) risks are found to be on the top of the priority
list, which needs urgent attention while embarking on I4.0 adoption in the industry, and the most
important criteria, which needed urgent attention was Information Security. The paper has also developed
the ‘Industry 4.0 Risks Iceberg model’ and systematically categorized the challenges into 5
dimensions for easy assessment and analysis.

Practical Implications:

This systematic and holistic study of the I4.0 associated risks can be used to
find the most critical and crucial risks based on which the strategies and policies may be modified to
harness the best of I4.0. This will not only ensure the returns on investment but also will build trust
in the system. The research would be very beneficial to managers, academicians, researchers, and
technocrats who would be involved in I4.0 implementation.
Video Consultations for Older Adults With Multimorbidity During the COVID-19 Pandemic: Protocol for an Exploratory Qualitative Study
Authors: Lee Eng Sing , Lee Poay Sian Sabrina , Chew Evelyn Ai Ling , Muthulingam Gayathri , Koh Hui Li , Tan Shu Yun , Ding Yew Yoong
Published: September 2020

Background

Multimorbidity, the coexistence of multiple chronic conditions in an individual, is a growing public health challenge. Amidst the COVID-19 pandemic, physical distancing remains an indispensable measure to limit the spread of the virus. This pertains especially to those belonging to high-risk groups, namely older adults with multimorbidity. In-person visits are discouraged for this cohort; hence, there is a need for an alternative form of consultation such as video consultations to continue the provision of care.

Objective

The potential of video consultations has been explored in several studies. However, the emergence of COVID-19 presents us with an unprecedented opportunity to explore the use of this technological innovation in a time when physical distancing is imperative. This study will evaluate the sustainability of video consultations on a micro-, meso-, and macro-level by assessing the views of patients, physicians, and organizational and national policymakers, respectively.

Methods

The NASSS (nonadoption, abandonment, scale-up, spread, and sustainability) framework was designed as a guide for the development of health care technologies. In this study, the implementation of and experiences related to video consultations will be studied using the NASSS framework. Individual in-depth interviews or focus group discussions will be conducted with participants using the Zoom platform. Data will be analyzed by at least two investigators trained in qualitative methodology, organized thematically, and coded in two phases—an initial phase and a focused selective phase. All disagreements will be resolved by consulting the larger research team until consensus is reached.

Results

This study was approved for funding from the Geriatric Education and Research Institute. Ethics approval was obtained from the National Healthcare Group Domain Specific Review Board (reference #2020/00760). Study recruitment commenced in July 2020. The results of the data analysis are expected to be available by the end of the year.

Conclusions

This study aims to evaluate the adoption and sustainability of video consultations for older adults with multimorbidity during the pandemic as well as post COVID-19. The study will yield knowledge that will challenge the current paradigm on how care is being delivered for community-dwelling older adults with multimorbidity. Findings will be shared with administrators in the health care sector in order to enhance the safety and quality of these video consultations to improve patient care for this group of population.

International Registered Report Identifier (IRRID)

DERR1-10.2196/22679
The mediating role of resilience on the association between self-efficacy and prenatal anxiety among pregnant women: A multi-site smart phone survey in China (Preprint)
Authors: Ma Ruqing , Zou Changqing , Zhang Lijuan , Sznajder Kristin K. , Yang Fengzhi , Jia Yajing , Cui Can , Zhang Weiyu , Zhang Wenzhu , Zou Ning , Yang Xiaoshi
Published: September 2020

BACKGROUND

Prenatal anxiety is one of the most prevalent mental disorders in prenatal period. Self-efficacy and resilience, the well-known positive resources, could help prevent the symptoms of anxiety during pregnancy.

OBJECTIVE

This study assessed the prevalence of prenatal anxiety and examine whether resilience could play a mediating role in the relationship between self-efficacy and prenatal anxiety of Chinese pregnant women.

METHODS

From July 2018 to July 2019, a multi-site smart phone survey was carried out in three cities (Shenyang in Liaoning province, Zhengzhou in Henan province and Chongqing) in China. A total of 665 pregnant women participated in the study. A hierarchical multiple regression (HMR) model was used to test the predictors and mediators of prenatal anxiety. A structural equation model (SEM) was applied to test the hypothesis that resilience mediates the relationship between self-efficacy and prenatal anxiety.

RESULTS

The HMR model indicated that self-efficacy contributed most to the variance (11.9%) of prenatal anxiety and had a significant negative correlation with prenatal anxiety (P<0.01) among pregnant women. Resilience had a significant positive correlation with self-efficacy (P<0.01) and was negatively correlated with prenatal anxiety (P<0.01). Resilience served as a mediator between self-efficacy and prenatal anxiety (a*b = -0.198, BCa 95% CI: -0.270, -0.126).

CONCLUSIONS

Self-efficacy was a negative predictor of prenatal anxiety for pregnant women. Moreover, resilience played a mediating role on the association between self-efficacy and prenatal anxiety among pregnant women in nationwide China. This study suggested that pregnant women might benefit from interventions to relieve prenatal anxiety through improved self-efficacy and the mediating path of resilience.
Determination of Risk Areas in the Cimahi City (Drainage Sector) Based on City Sanitation Strategy Guidelines
Authors: Juwana Iwan , Utami Elvira Rizqita
Published: September 2020

Cimahi is one of the cities which participated in the Accelerated Habitat Sanitation Development Program in 2011 due to its poor sanitation conditions. The city experienced high flooding in 2018 as observed in the 36.4 hectares or approximately 0.76% of the total area affected even though its drainage system was discovered to be covering 89.87% in 2015. There are also several reports of displacement of residents and significant financial loss in the city due to flooding in the past decade and this means urgent attention needs to be provided to improve the condition of the city. Therefore, this study was conducted to calculate the level of risk from the drainage sector in each urban village of Cimahi City. This involves using scores ranging from 1 – 4, with a score of 1 indicating very low risk while 4 represents very high risk based on exposure factors such as percentage of inundation area, sanitation risk index (IRS) score, and the opinions of local government as well as impact factors such as population, population density, poverty rate, and urban/rural function. The research made use of both primary and secondary data with the primary data obtained through interviews with the population in the study area and local government representatives while secondary data were obtained from different institutions. The results showed 7 out of the 16 urban villages in Cimahi City are in Risk Category 1, 5 in Category 2, 1 in Category 3, and the remaining 2 in Category 4. This information with the risk category map for each village is expected to be used by the local government of Cimahi to analyze the flood-related problems better and create more effective solutions.
2D Shallow Water Model for Dam Break and Column Interactions
Authors: Putri Putu Indah Dianti , Iskandar Rifqi Fauzan , Adityawan Mohammad Bagus , Kardhana Hadi , Indrawati Dian
Published: September 2020

Dam break causes disastrous effects on the surrounding area, especially at the downstream, therefore, there is a need for accurate and timely predictions of dam break propagation to prevent both property damage and loss of life. This study aimed to determine the movement of dam-break flow in the downstream area by solving the Shallow Water Equations (SWE) or Saint Venant Equations which are based on the conservation of mass and momentum derived from Navier Stokes equation. The model was generated using a finite difference scheme which is the most common and simplest method for dam-break modeling while Forward Time Central Space (FTCS) numerical scheme was applied to simulate two-dimensional SWE. Moreover, the accuracy of the numerical model was checked by comparing its results with the analytic results of one-dimensional cases and a relatively small value of error was found in comparison to the analytic models as indicated with the RMSE values close to 0. The numerical to the two-dimensional models were also compared to a simple dam break in a flume and dam break with column interactions and the wave propagation in both cases was observed to become very close at a certain time.  The model, however, used numerical filter (Hansen) to reduce the oscillations or numerical instability. The simulation and analysis, therefore, showed the ability of the numerical scheme of FTCS to resolve both cases of the simple dam break and dam break with column interactions in the Two-dimensional Shallow Water.
Resurgimiento de enfermedades infecciosas y movimiento antivacunas, ¿qué pasa en México?
Authors: Ramírez Aranda José Manuel , Hinojosa Moreira Vania Gabriela , Barragán Hernández Paulina Alejandra
Published: September 2020

En los últimos años se ha documentado una disminución en la cobertura de vacunación en todo el mundo por causas complejas y diversas dando como resultado el resurgimiento de enfermedades infecciosas. En 2017 se presentaron 173 330 casos confirmados de sarampión en 183 países; en México solo se han reportado veinte casos, asociados a importación. En 2019 se cumplieron 28 años de la eliminación de la poliomielitis en América; actualmente ha habido brotes en 21 países y el virus es endémico en Nigeria, Afganistán y Pakistán. También se han registrado dos epidemias de tosferina en los Estados Unidos (2010 y 2014) y en México se notificaron 314 casos. Todo lo anterior podría explicarse en parte por el movimiento antivacunas, definido como el rechazo de la vacuna a pesar de su disponibilidad, surgido tras una investigación publicada en Lancet por Wakefield y cols, en el que se asociaba la vacuna triple viral con el autismo. Lancet lo retiró poniendo en duda esas conclusiones, esa investigación se considera uno de los mayores fraudes científicos de la historia, que propició una caída en las tasas de vacunación. Múltiples estudios han refutado el argumento antivacuna como la demostración de una disminución de la morbilidad y mortalidad por el uso de vacunas en un 92% y 99%, respectivamente. Es necesario utilizar estrategias científicamente respaldadas para impedir el crecimiento de este fenómeno. El movimiento antivacunas ha derivado también en diversos planteamientos éticos, como si la inmunización de los niños debe ser obligatoria, entre otros.
COVID-19 and Cystic Fibrosis: Diagnostic Difficulties or Incorrect Methods?
Authors: Pecho-Silva Samuel , Navarro-Solsol Ana Claudia , Panduro-Correa Vicky , Arteaga-Livias Kovy , Rodriguez-Morales Alfonso J. , Dhama Kuldeep
Published: September 2020

Cystic fibrosis (CF) is a chronic lung disease with wide distribution worldwide. With the appearance of the Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), difficulties arise when evaluating, diagnosing, and treating patients with other conditions, including CF. We present the case of a patient with CF who had a definite serological diagnosis, a CT scan suggestive of SARS-CoV-2 infection/COVID-19, and a negative molecular test (RT-PCR), with rapid resolution of symptoms and early discharge. CF/SARS-CoV-2 comorbidity needs to be adequately studied and assessed in the context of the COVID-19 pandemic.
Morphological and DNA-based Classification of Cyathus sp. Isolates from Thailand (Basidiomycota, Nidulariaceae)
Authors: Sutthisa Waraporn , Sanoamuang Niwat
Published: September 2020

Cyathus sp. isolates from three areas in Thailand (Khon Kaen University, Nam Nao National Park and Phu Ruea, Loei Province) were morphologically characterized by their peridiocarp, peridioles and basidiospores. This allowed to assign most isolates to five Cyathus species: C. berkeleyanus, C. earlei, C. pallidus, C. stercoreus and C. striatus. Phylogenetic analysis of ribosomal ITS sequence data yielded three groups of Cyathus isolates and unidentified species group. The Pallidum group including KKUNN1, is closely related to C. berkeleyanus (DQ463355.1), KKUITN2 (KU202745) and KKUITN3 (KU202751) are closely related to C. pallidus (DQ463356.1). The Ollum group includes C. africanus and C. hookeri. The Striatum group, such as KKUITP2 (KU202744) and KKUITP3 (KU202743) are closely related to C. stercoreus (DQ463356.1). The LSU sequence data suggest that KKULN2 and KKULN3 are closely related to C. pallidus (DQ463336.1), whereas KKULP2 and KKULP3 are closely related to C. stercoreus.
The Phytochemical Analysis and Synergistic Antifungal Effect of Etlingera elatior Jack. Flowers and Murraya koenigii Spreng. Leaves against Candida albican
Authors: Othman Zulhabri , Ali Fasehah , Zajmi Asdren
Published: September 2020

Traditional medicinal plant possessed antimicrobial properties. Candidiasis is an infection of Candida albicans which has developed resistance towards antifungal drugs. The extracts of Murraya koenigii Spreng leaves and Etlingera elatior Jack flowers were used as antifungal agents individually and in combination against C. albicans. Both extracts were tested for the presence of phytochemicals (alkaloids, tannins, flavonoids, glycosides and saponins). Individual extracts were examined for antifungal activity using Kirby-Bauer test. The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were evaluated using microdilution broth assay and checkerboard assay. The extracts of both plants were positive for the presence of phytochemicals flavonoids, alkaloids, tannins, glycosides and saponins. The inhibition zone of M. koenigii leaf and E. elatior flower extracts were 8.33 mm and 8.17 mm respectively. The MIC of M. koenigii and E. elatior ranged from 200 mg/mL to 400 mg/mL and in combination, the extracts were indifferent towards C. albicans (FIC=1.0). MFC revealed there was no visible growth of C. albicans on SDA plate. M. koenigii and E. elatior have potential to be used individually or in combination as antifungal agents against C. albicans.
Bacterial Load Assessment of some Food Items Sold in Street in Woldia Town, North-East Ethiopia
Authors: Alem Kindu
Published: September 2020

Infectious diseases due to contaminated street vended food items has happened to an essential concern and public health issue in low socio-economic status individuals. The goal of this study was to evaluate bacterial quality and safety of some food items sold in street based on aerobic mesophilic bacteria, Salmonella, Staphylococcus aureus and Escherichia coli in Woldia town. Cross-sectional study was performed on some selected street vended foods from March 2019 to May 2019 in Woldia town. A total of 36 ready-to-eat food samples such as ‘Sambussa’, ‘Bonbolino’ and ‘Ambasha’ were collected for microbial analysis. Finding of the study indicates that 32(88.9 %) of the vendors were females, 28(77.7%) handled food with bare hands, 28(77.7%) vendors were washing their hands after toilet. The mean total count of aerobic mesophilic bacteria, Salmonella, Staphylococcus aureus and Escherichia coli was 4.5×102±5.2×101 CFUg-1, 1.5×102±4.5×101 CFUg-1, 1.1×102±1.4×101 CFUg-1 and 2×102±3.4×101 CFUg-1, respectively. The dominant bacterial isolate from the street vended foods was Escherichia coli (53.5%), followed by Salmonella (24.1%) and Staphylococcus aureus (22.4%). The result of this study demonstrates the non hygienic practices of the vendors in street vended foods showed high bacterial load. Therefore, the street vended foods were contaminated with food borne pathogenic bacteria that can create a potential risk to public health in the study area. In general, the bacterial quality of the food quality sold in street in Woldia town was very poor and needs especial attention to avoid bacterial contamination.
Rising Threat of OXA-48 and other Carbapenemase Encoding Genes among Carbapenem Resistant Enterobacteriaceae in India
Authors: Pawar Satyajeet K. , Mohite Shivaji T. , Datkhile Kailash D. , Patil Madhavi N. , Kakade Satish V.
Published: September 2020

Members of Enterobacteriaceae family are responsible for both community and hospital acquired infections. Because of development of antimicrobial resistance carbapenem has remained as last resort of drug for treatment of infections caused by these bacteria.Mechanism for development of this resistance in carbapenem resistant Enterobacteriaceae (CRE) may due to production of carbapenemases, efflux mechanism or loss of outer membrane porins.The most common carbapenemase enzymes are Class A – KPC, Class B – NDM, VIM and IMP and Class D oxacillinase(OXA-48 like enzymes).In India, most prevalent carbapenemase encoding gene is NDM-1but there is rising threat of OXA-48 prevalence. Unlike the phenotypic methods, the genotypic methods are useful to discriminate the type of carbapenemase enzyme, specifically for OXA-48 like enzymes. Total 170 CRE isolates were subjected for multiplex PCR study for their molecular characterization. Of the 170 CRE isolates,68.2 % (n=116) were positive for NDM-1 gene while 44.1 % (n= 75) of the isolates showed presence of OXA-48 gene. VIM (2.3%), KPC (1.7 %) were responsible for carbapenemase production while none of the isolates showed presence of IMP gene. NDM-1 and OXA-48 coexisted in 21.2 % (n=36) of the total isolates. OXA-48 causes weak hydrolysis of carbapenem because of which it is under reported with routine diagnostic methods. Early detection of OXA-48 and other carbapenemase encoding genes, helps for contact precautions and effective therapy which prevents further escalation and horizontal spread of CRE.
UMA PROPOSTA DE CATEGORIZAÇÃO DO PROCEDIMENTO LEGISLATIVO DE INICIATIVA POPULAR
PROPOSAL FOR CATEGORIZING THE LEGISLATIVE PROCEDURE FOR POPULAR INITIATIVE
Authors: Corrêa Bruna Bottero , Marchiori Neto Daniel Lena , Ferri Caroline
Published: September 2020

O presente artigo tem como tema a Iniciativa Popular Legislativa observada a partir do procedimento legislativo adotado para seu trâmite. O objetivo é problematizar os seus ritos, verificando em que medida eles a efetivam como meio de exercício da soberania popular. De maneira ensaística, a Iniciativa Popular Legislativa é apresentada em categorias, ilustradas com a ajuda de características procedimentais de modelos já praticados. A categorização geral obtida pode ter por fim enquadrar procedimentos já existentes, bem como oferecer um parâmetro de referência para a criação de novos modelos.
A OMISSÃO DA CORTE INTERAMERICANA DE DIREITOS HUMANOS NA PROTEÇÃO DOS DIREITOS ECONÔMICOS, SOCIAIS E CULTURAIS: ANÁLISE A LUZ DO CASO CINCO APOSENTADOS VS PERU
THE OMISSION OF THE INTERAMERICAN COURT OF HUMAN RIGHTS IN THE PROTECTION OF ECONOMIC, SOCIAL AND CULTURAL RIGHTS: ANALYSIS IN LIGHT OF THE CASE OF FIVE RETIRED PERSONS V PERU
Authors: Mezacasa Douglas Santos , Amorim Dandara C. A. de , Bambirra Felipe Magalhães
Published: September 2020

O presente artigo busca analisar a omissão das sentenças da Corte Interamericana de Direitos Humanos nos casos de violação dos direitos de segunda geração, mais especificamente, nos direitos sociais. No primeiro momento, o artigo aborda as gerações dos direitos fundamentais (sem entrar na discussão terminológica das eras desses direitos) para demonstrar a evolução da proteção dos direitos humanos ao longo da história. É demonstrada a interferência dos fatores históricos e mundiais que contribuíram para a efetivação da proteção desses direitos. Posteriormente, é abordado, de forma resumida, o caso dos “cinco aposentados contra o estado do Peru”, no qual aqueles recorreram à Corte Interamericana de Direitos Humanos no intuito de recuperarem suas aposentadorias reduzidas pelo Estado. Por fim, é analisada a decisão da Corte no caso citado, constatando-se a sua omissão, que, como demonstrado na conclusão, incrementa a insegurança jurídica e não se alinha aos padrões de proteção exigíveis aos Direitos Humanos.
INSIGNIFICÂNCIA: A NECESSÁRIA OFENSA A BENS JURÍDICOS COMO CONTEÚDO DO CRIME E A VISÃO DISTORCIDA DO SUPREMO TRIBUNAL FEDERAL
INSIGNIFICANCE: THE NECESSARY OFFENSE TO LEGAL ASSETS SUCH AS CRIME CONTENT AND THE DISTORTED VIEW OF THE FEDERAL SUPREME COURT
Authors: Siqueira Neto José Francisco , Menezes Daniel Francisco Nagao
Published: September 2020

O presente artigo aborda a compreensão atual da insignificância na ordem jurídica brasileira. Para tanto, a matéria será revisada desde a teoria do bem jurídico a partir de Fuerbach e Birnbaum, analisando a ofensividade e o conteúdo material do delito. Após o intróito estudaremos a insignificância, tal como pensada por Claus Roxin. Por fim, apresentaremos a interpretação principiológica da insignificância pela doutrina brasileira e as consequências deste tratamento afetando a jurisprudência pátria. Para isso, será demonstrado de forma qualitativa interpretações decisórias do STF que objetivam afastar os critérios de lesividade por parâmetros subjetivos ou morais e abstratos, arrematando de forma crítica a abordagem sobre o tema.
Investment projects in the largest cities of the Samara region
Authors: Mironova Marina N. , Rodina Maria E.
Published: September 2020

The article is devoted to the study of the sectoral and territorial structure of investment industrial projects in order to identify the potential development of the Samara region in a 30-year perspective. The main information of the study was the data on the developed and implemented investment projects of 2008-2048 from the Fund Agency for Attracting Investments of the Samara Region. It was revealed that more than 80% of the total investment in these projects is related to strategic projects designed to ensure the integrated development of the region. This implies the future changes in the sectors of the regional economy and its spatial development. 144 regional investment projects were considered, 79 of which are industrial and at the same time concentrate 2/3 of all investments. The analysis showed that the number of investment projects in the manufacturing industry of traditional areas prevails, however, 75% of the financial resources are allocated for the development of the fuel industry (the creation of oil refineries). A significant part of the projects is located in the largest cities: about 90% of all investments were directed to four cities - Samara, Novokuybyshevsk, Syzran and Tolyatti. The most important investment industrial projects are described for these cities, they make adjustments to their city-forming functions. Information and statistical base are materials of the Federal State Statistics Service and sites of cities of the Samara region also. The region specificity of current socio-economic situation is characterized and the industrial profile is determined. The most important cities are described as the centers of the region by their location, the main industries and leading enterprises. A comparison of the existing sectoral and territorial features of Samara regional economy and its investment projects allowed to draw the following conclusions. The most of industrial projects are implemented in the same industries that are basic in the economy of the region, so it will continue in the future. The role and importance of oil refining in the economy will increase significantly, while the manufacturing industry will decrease. The spatial picture of the economy will not change, but the imbalances will increase due to the development of large-scale oil refining projects in the largest cities of the Samara region. The processes of diversification of industrial production will mainly affect the development of the cities of Togliatti and Samara.
Problems of developing the customs and logistics infrastructure of the East-West International Transport Corridor
Authors: Fedorenko Roman V.
Published: September 2020

The aim of this work is to identify key aspects of the impact of customs and logistics infrastructure on patterns of change in trade between the countries participating in the East-West International Transport Corridor. Author identifies factors that have the greatest impact on the volume of freight traffic and highlights the prospects for the development of foreign trade cooperation. The article describes the main problems hindering the full use of the transit potential of the transport corridor, and indicates areas for improving its transport and customs and logistics infrastructure. The relevance of the studied problem is due to the increased interest of the participating countries of the East-West International Transport Corridor to its further development and increase in mutual trade. The scientific significance of this problem is due to the need for an integrated approach to forming the framework of the international transport corridor, combining terminal-warehouse infrastructure, a customs administration system and a range of services arranged by logistics providers and customs intermediaries. Currently, there is no comprehensive understanding of the processes of organizing the movement of international goods flows. This combined understanding should unite issues of customs escort, development of terminal handling of goods, embedding the existing logistics infrastructure in the international transport corridor and ensuring the attractiveness of this route both for foreign companies using it as a transit route and for enterprises aimed at exporting their products.
Analisis Faktor Risiko Gejala Depresi Pada Ibu di Masa Nifas di Kecamatan Banjarsari, Surakarta
Authors: Widarini Yustisia Imaninditya Puteri , Arifah Izzatul , Werdani Kusuma Estu
Published: September 2020

Abstract

Women are prone to experiencing postpartum depression. The purpose of this study was to analyze the association of risk factors and depression symptoms in postpartum mothers in Banjarsari District, Surakarta in 2019. The design of the research is cross-sectional with the total sample was.160 postpartum mothers (0-6 weeks) from the total population of 268 mothers The independent variables included the mother’s age, education, occupation, type of delivery exclusive breastfeeding practice, and the first time breastfeeding. Whereas, the dependent variables were the symptoms of postpartum depression. Data collection using the exclusive breastfeeding practice questionnaire and the Edinburgh Postnatal Depression Scale (EPDS). Data analysis was performed using Chi-square and multivariate logistic regression. The results showed that 25.6% of mothers in Banjarsari experienced symptoms of postpartum depression. Type of labor (p=0,049, OR 2,333, 95% CI 1,002-5,428) and exclusive breastfeeding practice (p=0,018, OR 2,460 95% CI 1,1665,187) were significantly associated with symptoms of postpartum depression. The study concluded that the group of mothers who did exclusive breastfeed and who had delivery complications tended to experience symptoms of postpartum depression higher than that of mothers who did not experience the same conditions.

Keywords : postpartum, depression, EPDS

Abstrak

Perempuan rentan mengalami depresi masa nifas. Tujuan penelitian untuk menganalisis hubungan faktor risiko dengan gejala depresi pada ibu di masa nifas di Kecamatan Banjarsari, Surakarta. Desain penelitian adalah crossectional dengan sampel 160 ibu nifas (0-6 minggu) dari total populasi 268 orang, Penelitian mengukur variabel independen yaitu usia ibu, pendidikan, pekerjaan, jenis persalinan, praktik menyusui eksklusif dan waktu pertama kali menyusui dengan variabel dependen yaitu gejala depresi pada ibu di masa nifas. Pengumpulan data menggunakan kuesioner praktik menyusui eksklusif dan Edinburgh Postnatal Depression Scale (EPDS). Analisis data menggunakan Chi-square dan multivariat menggunakan regresi logistik. Hasil penelitian menunjukkan 25,6% ibu di Kecamatan Banjarsari, Surakarta mengalami gejala depresi di masa nifas. Jenis persalinan (p=0,049, OR 2,333, 95% CI 1,002-5,428) dan praktik menyusui eksklusif (p=0,018, OR 2,460, 95% CI 1,166-5,187) berhubungan signifikan dengan gejala depresi masa nifas. Kesimpulan penelitian ini adalah kelompok ibu yang tidak menyusui eksklusif dan kelompok ibu yang jenis persalinan disertai penyulit cenderung mengalami gejala depresi lebih tinggi dibandingkan kelompok ibu yang tidak mengalami kondisi yang sama.

Kata kunci: postpartum, depresi, EPDS
Deprescribing Guidelines: Value of an Interactive Mobile Application
Authors: Farrell Barbara , Grad Roland , Howell Pam , Quast Tammie , Reeve Emily
Published: September 2020

Introduction: We developed a new channel on a mobile app as a continuing education tool to augment the use of deprescribing guideline content in clinical practice. In this research brief, we describe the reach and adoption of channel content, as well as user feedback.
Methods: Using Google Analytics, we counted page views of the website (deprescribing.org) where the app was promoted. We calculated total app downloads, monthly active users, and guideline-specific page views. Users were invited to complete the embedded Information Assessment Method (IAM) Questionnaire to obtain feedback on the value of information presented on the Deprescribing Channel.
Results: Between March 2, 2019 and November 30, 2019, we documented 9,454 page views of the promotional web page across 40 countries. The Deprescribing Channel was downloaded 3,256 times with an average of 464 monthly users. In total, the guidelines on this channel were accessed 14,377 times with 49,721 views across all guideline pages. Thirty-seven IAM questionnaires were completed. Thirty-two responses indicated this deprescribing information was relevant for at least one of their patients. Regarding educational outcomes, 22 responses were of learning something new and/or being motivated to learn more.
Conclusion: We documented international interest in a mobile app providing continuing education on deprescribing. App users generated sustained page views over the study period. Feedback from a small number of users was positive with the majority finding the content relevant, educational, and applicable to patient care. Further work is needed to improve the usability of the embedded feedback questionnaire and to evaluate its value in supporting learning.
Borellia burgdorferi infection in removed ticks and anti-borrelia antibodies in infested patients admitted to the Pasteur institute, Novi Sad
Authors: Simin Verica , Lalosevic Dusan , Mijatovic Dragana , Tomanovic Snezana , Miljevic Milan , Cabrilo Borislav , Bogdan Ivana , Banovic Pavle
Published: September 2020

The primary objectives of this study were (1) to determine the presence of Borrelia burgdorferi infection in ticks removed from patients for the purpose of singling out sites with increased risk of Lyme borreliosis, and (2) to determine the presence of IgM and/or IgG antibodies against B. burgdorferi sensu lato (s. l.) complex in sera of patients who had ticks removed. From 108 ticks removed from patients, all were examined zoologically and a sub-sample of 91 ticks was tested using PCR analysis to determine the presence of DNA indicating B. burgdorferi infection. To detect anti-Borrelia IgM and/ or IgG antibodies in 61 patients bitten by ticks, we used line recombinant immunoblot test. The most common tick identified was Ixodes ricinus. B. burgdorferi s. l. was present in 37 of 91 tested ticks (40.7%). Seroconversion against B. burgdorferi s. l. antigen was detected in 12 of 61 patients (19.7%). Most of the infected ticks were from the province of Vojvodina (11 municipalities), with the city of Novi Sad proving to be the site with the highest number of infected ticks, 6 in total.