bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary grape seed tannin extract supplementation stimulated testis development, changed fatty acid profiles and increased antioxidant capacity in testis in Hu lambs in pre-puberty
Authors: Li Wanhong , Yao Rongyu , Xie Lixia , Liu Jiamei , Weng Xiuxiu , Yue Xiangpeng , Li Fadi
Published: March 2021

Background
Grape seed tannin extract (GPE) that is from wine grape pomace has many effective anti-oxidative effects and is used as a promising natural feed additive in the animal feed industry. In this study, we investigated the effect of GPE as a source of tannin on the antioxidant capacity and testis development in Hu lamb.
Method:
Twenty-seven 3-month-old ram lambs were randomly assigned to three groups. Within each treatment group, nine lambs were allocated to nine pens (one lamb per pen). The lambs in the control group were fed a control diet without GPE for 61 days from D21 to D80. Group I (TAN1) was fed a 0.36% GPE diet. Group II (TAN2) was fed a 0.72% GPE diet. After 81-day feeding trial, all lambs except the heaviest and lightest in each group were humanely slaughtered and investigated.
Results
Feeding GPE did not affect the body weight, average daily gain, dry matter intake, scrotal circumference and testis index, whereas feeding 0.36% GPE diet increased testis weight, testis volume, and epididymis weight (P < 0.05) compared with the control. Cu-ZnSOD, P450scc, P450arom, FSHR, FADS2, ELOVL2 and PCNA mRNA in TAN1 and TAN2 groups were significantly up-regulated (P < 0.05). GPE also markedly increased antioxidant status of testis. Compared with the control group, GPE significantly increased the SOD activity (314.23 ± 18.64 U/mg prot in control, 505.22 ± 63.47 U/mg prot in TAN1 and 587.88 ± 55.94 U/mg prot in TAN2, P < 0.05), T-AOC (98.23 ± 18.99 U/g prot in control, 202.15 ± 34.19 U/g prot in TAN1 and 189.57 ± 18.95 U/g prot in TAN2, P < 0.05). GPE also increased NEFAs levels (158.36 ± 26.32 mmol/kg prot in control, 205.15 ± 14.51 mmol/kg prot in TNA1 and 250.06 ± 33.82 mmol/kg prot in TAN2 P = 0.08). But, consuming GPE downregulated testicular total cholesterol concentration (3.89 ± 0.57 mmol/kg prot in TAN1, 4.21 ± 1.04 mmol/kg prot in TAN2 and 7.20 ± 1.46 mmol/kg prot, P = 0.09). Consuming 0.72% GPE also changed fatty acid profiles in testis with increased C15:1, C22:6n3 and total n-3 fatty acids (P < 0.05). Therefore, feeding lambs with 0.72% GPE stimulated testis seminiferous tubule development, increased the number of Sertoli cells (10.56 ± 0.44 vs. 13.60 ± 0.42, P < 0.05), and seminiferous tubule diameter (146.56 ± 4.53 µm vs. 109.3 ± 4.56 µm, P < 0.05).
Conclusion
All these results suggested that feeding GPE in the early reproductive development stage of lambs upregulated the expression of antioxidative, steroidogenesis, and PUFA metabolism-related genes; changed the fatty acids profiles, increased the antioxidant capacity in lamb’s testis; and contributed to testis development and spermatogenesis.
PD-L1 upregulation is associated with activation of the DNA double-strand break repair pathway in patients with colitic cancer
Authors: Ozawa Naoya , Yokobori Takehiko , Osone Katsuya , Katayama Chika , Suga Kunihiko , Komine Chika , Shibasaki Yuta , Shiraishi Takuya , Okada Takuhisa , Kato Ryuji , Ogawa Hiroomi , Sano Akihiko , Sakai Makoto , Sohda Makoto , Ojima Hitoshi , Miyazaki Tatsuya , Motegi Yoko , Ide Munenori , Yao Takashi , Kuwano Hiroyuki , Shirabe Ken , Saeki Hiroshi
Published: March 2021

Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the DNA double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) pathway can induce PD-L1 expression transcriptionally. However, the association of PD-L1/DSB/IRF-1 with sporadic colorectal cancer (SCRC), and UC-associated dysplasia/colitic cancer, remains elusive. Therefore, we investigated the significance of the PD-L1/DSB repair pathway using samples from 17 SCRC and 12 UC patients with rare UC-associated dysplasia/colitic cancer cases by immunohistochemical analysis. We compared PD-L1 expression between patients with SCRC and UC-associated dysplasia/colitic cancer and determined the association between PD-L1 and the CD8+ T-cell/DSB/IRF-1 axis in UC-associated dysplasia/colitic cancer. PD-L1 expression in UC and UC-associated dysplasia/colitic cancer was higher than in normal mucosa or SCRC, and in CD8-positive T lymphocytes in UC-associated dysplasia/colitic cancer than in SCRC. Moreover, PD-L1 upregulation was associated with γH2AX (DSB marker) and IRF-1 upregulation in UC-associated dysplasia/colitic cancer. IRF-1 upregulation was associated with γH2AX upregulation in UC-associated dysplasia/colitic cancer but not in SCRC. Multicolour immunofluorescence staining validated γH2AX/IRF-1/PD-L1 co-expression in colitic cancer tissue sections. Thus, immune cell-induced inflammation might activate the DSB/IRF-1 axis, potentially serving as the primary regulatory mechanism of PD-L1 expression in UC-associated carcinogenesis.
Influence of the Semiconductive Composites Doped with Li4Ti5O12 on Space Charge Implantation in LDPE
Authors: Yin Hongxia , Zhao Shiyi , Hao Chuncheng , Lei Qingquan
Published: March 2021

Space charge accumulation in the insulating layers of high-voltage directed current (HVDC) cables is the key factor that leads to their degradation and limits the operation safety. Hence, it is necessary to effectively inhibit carrier implantation to these layers. In this study, a new method is proposed to suppress the charge implantation to the cable insulation layer, a certain amount of Li4Ti5O12 nanopowder is doped in the semiconductive screen to enhance the internal conductive network and homogenize the electric field. The influences of Li4Ti5O12 particles in the semiconductive composite screen on the positive temperature coefficient effect and space charge injection process are explored. The obtained results reveal that the charge quantity in the insulation layer corresponding to the minimum peak resistivity is reduced by 49.7%, 58.9%, and 46.9% after the polarization at a Li4Ti5O12 content of 4 wt.% and electric field strengths of 10, 20, and 30 kV/mm, respectively.
W27 IgA suppresses growth of Escherichia in an in vitro model of the human intestinal microbiota
Authors: Sasaki Kengo , Mori Tomoyuki , Hoshi Namiko , Sasaki Daisuke , Inoue Jun , Shinkura Reiko , Kondo Akihiko
Published: March 2021

W27 monoclonal immunoglobulin A (IgA) suppresses pathogenic Escherichia coli cell growth; however its effect on the human intestine remains unclear. We thus aimed to determine how W27 IgA affects the human colonic microbiota using the in vitro microbiota model. This model was established using fecal samples collected from 12 healthy volunteers; after anaerobic cultivation, each model was found to retain the genera found in the original human fecal samples. After pre-incubating W27 IgA with the respective fecal sample in aerobic condition, the mixture of W27 IgA (final concentration, 0.5 µg/mL) and each fecal sample was added to the in vitro microbiota model and cultured under anaerobic condition,. Next-generation sequencing of the bacterial 16S rRNA gene revealed that W27 IgA addition significantly decreased the relative abundance of bacteria related to the genus Escherichia in the model. Additionally, at a final concentration of 5 µg/mL, W27 IgA delayed growth in pure culture of Escherichia coli isolated from human fecal samples. Our study thus revealed the suppressive effect of W27 IgA on the genus Escherichia at relatively low-concentrations and the usefulness of an in vitro microbiota model to evaluate the effect of IgA as a gut microbiota regulator.
Understanding The Role Of Oxidative Stress In The Incidence Of Metabolic Syndrome And Obstructive Sleep Apnea
Authors: KARGAR Behnam , ZAMANIAN Zahra , HOSSEINABADI Majid Bagheri , Gharibi Vahid , MORADI Mohammad Sanyar , COUSINS Rosanna
Published: March 2021

Background: Understanding the causes and risk factors of metabolic syndrome is important for promoting population health. Oxidative stress has been associated with metabolic syndrome, and also obstructive sleep apnea. These are two diseases which have common prognostic characteristics for heart disease. The aim of this study was to examine the role of oxidative stress in the concurrent presence of metabolic syndrome and obstructive sleep apnea in a working population. Methods: Participants were 163 artisan bakers in Shahroud, Iran, routinely exposed to oxidative stress indicators on a daily basis as part of their work. Using a cross-sectional design, data relevant to determining metabolic syndrome status according to International Diabetes Federation criteria, and the presence of obstructive sleep apnea according to the STOP-Bang score, was collected. Analyses included hierarchical binary logistic regression to yield predictors of the two diseases. Results: Logistic regression showed that oxidative stress – alongside obesity, no regular exercise, and smoking – was an independent predictor of metabolic syndrome, but not obstructive sleep apnea. Participants who were obese were 28 times more likely to have metabolic syndrome (OR 28.59, 95% CI 4.91-63.02) and 44 times more likely to have obstructive sleep apnea (OR 44.48, 95% CI 4.91-403.28). Participants meeting metabolic syndrome criteria had significantly higher levels of malondialdehyde (p < 0.05) than those who did not. No difference in oxidative stress index levels were found according to obstructive sleep apnea status. Conclusions: Our findings suggest that oxidative stress contributes to the onset of metabolic syndrome, and that obstructive sleep apnea is involved in oxidative stress. Whilst obesity, exercise, and smoking remain important targets for reducing the incidence of metabolic syndrome and obstructive sleep apnea, policies to control risks of prolonged exposure to oxidative stress are also relevant in occupations where such environmental conditions exist.
Dezocine prevents sufentanil-induced respiratory depression during awake intubation: a multicenter, randomized, controlled study
Authors: Pan Xiao , Zou Hongyun , Li Rui , Xia Shujiang , Ju Xia , Zhang Qi , Xu Guanghong , Cheng Xinqi , Gu Erwei , Liu Xuesheng
Published: March 2021

BackgroundSufentanil has sedative and inhibitory effects on the intubation response, but high doses of sufentanil can cause coughing and respiratory depression. Dezocine has been documented effectively suppressing sufentanil-induced cough. Whether dezocine can inhibit the respiratory depression caused by sufentanil is unknown. This study aims to observe the efficacy of dezocine combined with sufentanil in awake intubation.MethodsFour hundred and three patients of American Society of Anesthesiologists physical status Classes I and II, aged 18–65 years, were randomly allocated into four groups: Group saline (saline + 0.4 ug/kg sufentanil), Group D0.05 (dezocine 0.05 mg/kg + 0.4 ug/kg sufentanil), Group D0.10 (dezocine 0.10 mg/kg + 0.4 ug/kg sufentanil), and Group D0.15 (dezocine 0.15 mg/kg + 0.4 ug/kg sufentanil). The primary outcome of our study was to observe the incidence of respiratory depression. Secondary outcomes included the success rate of intubation, ease of intubation, intubation comfort score, sore throat, hoarseness, lethargy, limb movement, glottis exposing and the satisfaction of patients during intubation. Hemodynamic changes were recorded after sufentanil injection and awake intubation.ResultsThere was no difference in the effect of normal saline and 0.05 mg/kg dezocine on respiratory depression (P = 0.603). The incidence of respiratory depression in Group D0.10 and Group D0.15 was lower than that of Group saline. Cough was statistically different between the four groups (P < 0.05). The incidence of cough in the dezocine groups was lower than that of Group saline. There was a significant difference in patient intubation satisfaction between the four groups (P < 0.05). The satisfaction of patients during intubation were significantly higher in the dezocine groups. Sore throat, hoarseness, lethargy and success rate of intubation were similar between the four groups (all P > 0.05).ConclusionsOur study indicated that 0.10 mg/kg and 0.15 mg/kg dezocine might prevent the occurrence of cough and respiratory depression induced by sufentanil during awake intubation and improve patient satisfaction.Trial registrationClinicaltrials.gov (NCT02673723), 2- 4- 2016.
Metabolites from Induratia spp. Modulating Key Enzymes in Human Hemostasis
Authors: Cardoso Mauro Guilherme Barros , Trento Marcus Vinicius Cardoso , Cesar Pedro Henrique Souza , Marcussi Silvana , CARDOSO PATRICIA GOMES
Published: March 2021

Fungi Induratia have been poorly evaluated for their non-volatile secondary metabolites. In the present work, we evaluated the effects of non-volatile secondary metabolites released into the culture medium by Induratia spp. upon toxic alterations induced by Bothrops spp. venoms. B. atrox venom phospholipase was inhibited by Induratia sp. and I. yucatanensis around 12 and 16%. The extracts of two strains inhibited 12 to 25% of the hemolysis induced by B.moojeni venom. Thrombolysis was inhibited by 30 to 60% by the compounds present in two extracts. The coagulation induced by B. moojeni venom was prolonged by 26 to 41 s by the action of the extracts of I. yucatanensis and I. coffeana. The fungal extracts did not exerted any cytotoxic effect, nor did they induce any alteration in the other evaluated substrates show the potential use of non-volatile metabolites produced by the fungi evaluated as enzyme modulators, especially for proteases with a fundamental role in human hemostasis.
 ‘I Can No Longer Do My Work Like How I Used To’: A Qualitative Longitudinal Cohort Study Exploring How Informal Working Mothers Balance The Requirements Of Livelihood And Safe Childcare In South Africa. 
Authors: Horwood Christiane , Hinton Rachael , Haskins Lyn , Luthuli Silondile , Mapumulo Sphindile , Rollins Nigel
Published: March 2021

Background: Returning to work after childbirth is challenging for working mothers. The quality of childcare may have lifelong effects on children’s health, development and cognitive function. Over 60% of working women globally are informal workers without employment or maternity protections, but little is known about how these women care for their children. Methods: We conducted a mixed methods longitudinal cohort study among informal women workers in Kwazulu-Natal, South Africa between July 2018 and August 2019. Participants were followed up from late pregnancy until they had returned to work. We conducted structured quantitative interviews and in-depth qualitative interviews before and after the baby was born, and after returning to work. We then brought groups of participants together for a photovoice activity to explore the childcare environment. Thematic analysis was used to analyse qualitative data in NVIVO v12.4 and SPSSv26 was employed to analyse quantitative data. Results: Women returned to work soon after the baby was born, often earlier than planned, because of financial responsibilities to provide for the household and the new baby. Women had limited childcare choices and most preferred to leave their babies with family members at home, as the most convenient, low cost option. Otherwise, mothers chose paid carers or formal childcare. However, formal childcare was reported to be poor quality, unaffordable and not suited to needs of informal workers. Mothers expressed concern about carers’ reliability and the safety of the childcare environment. Flexibility of informal work allowed some mothers to adapt their work to care for their child themselves, but others were unable to arrange consistent childcare, sometimes leaving the child with unsuitable carers to avoid losing paid work. Mothers were frequently anxious about leaving the child but felt they had no choice as they needed to work. Conclusion: Mothers in informal work had limited childcare options and children were exposed to unsafe, poor-quality care. Maternity protection for informal workers would support these mothers to stay home longer to care for themselves, their family and their baby. Provision of good quality, affordable childcare would provide stability for mothers and give these vulnerable children the opportunity to thrive.
Basal serum follicle-stimulating hormone and anti-mullerian hormone are the predictors of poor ovarian response among fertile and infertile women below the age of 40 years 
Authors: Khan Haroon Latif , Bhatti Shahzad , Imrana  , Humera  , Shuail Samina
Published: March 2021

Infertility is defined as the inability to conceive despite having frequent, unprotected sex for at least one year. The failure to have children affects men and women across the globe. Infertility can lead to distress and depression [1]. The clinical definition of infertility used by the World Health Organization (WHO) is "a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse" [2], while the WHO's epidemiologic definition is "women of reproductive age at risk of becoming pregnant who report unsuccessfully trying for a pregnancy for more than two years" [3]. Clinical definitions are designed for early detection and treatment of infertility [2]–[4]. A progressive decline in fecundity occurs in both males and females with advancing age. Generally, male factors contribute to one-third of infertility cases, the other one-third occurs due to female reproductive deficiencies, while in remaining cases, both male and female causes equally contribute towards infertility. In some cases, infertility is iatrogenic in nature as both male and female profile comes out to be normal and termed as unexplained infertility.
Integrated computational analysis revealed hub genes in lung adenocarcinoma
Authors: Jamal Muhammad , Khan Abdul Saboor , Bangash Hina Iqbal , Xie Tian , Song Tianbao , Lei Yufei , Li Jingyuan , Tan Haiyan , Zhang Qiuping
Published: March 2021

Background

Lung cancer (LUCA) is the leading cause of cancer-related morbidities and mortalities globally. Despite the recent advancements in lung cancer research, understanding of the molecular mechanism underlying LUCA tumorigenesis and prognosis remains suboptimal. This study aims to identify the candidate biomarkers and therapeutic genes in lung cancer.
Methods

In this study, gene expression profiles of GSE30219, GSE33532, GSE32863 and GSE43458 were downloaded from GEO. The differentially expressed genes (DEGs) in LUAD tissue and normal lung tissue with a p-value < 0.05 and a |log fold change (FC)| >1.0 were identified by GEO2R. For functional enrichment analysis of these DEGs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed with KOBAS and DAVID tools. Next, the candidate hub genes were filtered out with Cytoscape using CytoHubba plugin. These hub genes were validated by (the Cancer Genome Atlas) TCGA-based gene expression analysis, protein-protein network interaction (PPI) analysis, survival analysis. Moreover, the expression of these genes in cancer and normal tissue was assessed in the Human Protein Atlas (HPA) database. In addition, miRNA network of the hub genes was constructed. Finally, DGIdb database was used to check the drug-targeting potentials of the hub genes.
Results

a total of 332 overlapping differentially expressed genes (DEGs) including 73 upregulated and 259 downregulated, respectively were identified. GO analysis revealed that the DEGs were principally regulating various cancer-associated functions and pathways. The module analysis revealed 55 hub genes in 4 modules. The survival analysis through Kaplan-Meier (KM) plotter indicated that the altered expression of these genes resulted in the poor overall survival (OS) of LUCA patients. Moreover, these genes show a differential expression on both protein and mRNA level in cancer patient compared to the normal. In addition, in addition, 6 potential microRNAs (miRNAs) interacting with hub genes were identified. Finally, a list of 117 therapeutic small molecules was tabulated that could facilitate LUCA treatment.
Conclusions

the findings of this study may help in the development of novel and reliable biomarkers for diagnosis, prognosis and therapeutic intervention for LUAD.
Avascular Necrosis of Humeral Trochlea: A Case Report of the Rare Condition
Authors: Yilmaz Temel Fatih , Okutan Ahmet Emin , Ayas Muhammet Salih , Dada Mehmet Emin , Turhan Ahmet Uğur
Published: March 2021

İntroduction:

Avascular necrosis of humeral trochlea is a very rare condition and was
described by Hegemann in 1957. We reported two cases of avascular necrosis of humeral trochlea
and also performed a literature review of the reported cases. We expect that this case report will assist
clinicians in making a timely diagnosis when encountering similar clinical scenarios.

Materials and Methods:

We presented cases of an 11-year-old and a 14-year-old with avascular necrosis
of the humeral trochlea. The common etiology was idiopathic because there were no recent
trauma history and sports activity. Also, there was no history of drug use. We discussed the clinical
and radiological findings of these cases.

Results:

These cases, two teenage boys, were diagnosed withHegemann’s disease with clinical and
radiological outcomes. We found that the etiology of both thecases is idiopathic;. The number of
previously reported cases in the literature is limited to 64. In our study, there was a lateral crest in
one of our two cases and a posteromedial involvement in another. The radiograph of trochleae of these
two cases showed irregularity and granular appearance. In our case, heterogeneous signal
changed and irregularities were accompanied by hypointensive changes on T1-weighted images.
Also, hyperintensive changes on proton density sequences were detected.

Conclusion:

Radiological evaluation plays an important role in the diagnosis and evaluation of response
to treatment in avascular necrosis of the humeral trochlea. Avascular necrosis should be one
of the differential lesions involving the trochlea. Recognition of avascular necrosis in the trochlea
may prevent the unnecessary biopsy.
MANAJEMEN KULTUR SEKOLAH DALAM UPAYA PENINGKATAN MUTU PENDIDIKAN DI SMA NEGERI 2 BREBES
Authors: Saputri Evi Rovikoh Indah
Published: March 2021

Salah satu upaya yang dilakukan sekolah untuk meningkatkan prestasi siswa adalah mengembangkan kultur sekolah. Artikel ini bertujuan untuk menyajikan manajemen kultur sekolah di SMAN 2 Brebes sebagai upaya peningkatan mutu pendidikan yang meliputi kultur berprestasi, berkarakter, dan kegiatan ekstrakurikuler. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa manajemen kultur sekolah dilakukan dengan mengembangkan kultur berprestasi, berkarakter, dan kegiatan ekstrakurikuler. Kultur Berprestasi dilaksanakan  dengan kompetisi akademik, non-akademik, keikutsertaan lomba, pembelajaran efektif. Kultur berkarakter dilaksanakan dengan 18 nilai karakater yang harus dimiliki oleh warga sekolah serta kegiatan pembiasaan. Kegiatan ekstrakurikuler dilaksanakan meliputi kegiatan wajib dan pilihan. Upaya tersebut dilandasi oleh keinginan sekolah untuk berprestasi dalam rangka membangun kepercayaan masyarakat bahwa sekolah mampu mencetak siswa yang berprestasi dan menjadi kebanggaan.Kata kunci: Manajemen, Kultur sekolah, Mutu pendidikan
Profil kenakalan remaja dan implikasinya terhadap program bimbingan pribadi-sosial
Authors: Wahyuni Dieta Dwi , Nurmala Meilla Dwi
Published: March 2021

Penelitian ini dilatarbelakangi oleh adanya permasalahan kenakalan remaja yang terjadi pada siswa. Penelitian bertujuan untuk mengetahui gambaran umum kenakalan remaja khususnya pada siswa kelas XI di SMAN 5 Kota Serang, kemudian menyusun program bimbingan pribadi sosial sebagai implikasi dari penelitian untuk mencegah kenakalan remaja. Metode penelitian yang digunakan adalah penelitian deskriptif dengan pendekatan kuantitatif. Teknik pengambilan sampel menggunakan simple random sampling pada 171 siswa. Sedangkan teknik analisis data menggunakan statistik deskriptif. Penelitian mengenai kenakalan remaja dilakukan dengan melihat dua indikator kenakalan remaja yaitu Index Offenses dan Status Offenses sebanyak 36 item dan reliabitas 0,304. Berdasarkan analisis data, hasil penelitian menunjukkan tingkat kenakalan remaja di SMAN 5 Kota Serang berada pada kategori rendah dengan persentase sebesar 87%. Penyumbang terbesar dari angka ini adalah aspek Status Offenses dengan indikator mengontrol emosi, berbohong, membolos, memalak teman sebaya, merokok, dan perilaku seks pranikah yaitu sebesar 19% yang termasuk dalam kategori sedang. Setelah mengetahui gambaran umum kenakalan remaja, maka rancangan program dibuat berdasarkan hasil penelitian yang didapat.
Tradisi masyarakat pasca gempa 2006 di sriharjo
Authors: Maryani Maryani , Nurhayati Riana
Published: March 2021

Penelitian ini bertujuan untuk untuk memperoleh pemahaman tentang terjadinya pergeseran tradisi masyarakat pasca gempa 2006 di Sriharjo. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan jenis studi kasus. penelitian ini dilaksanakan di desa Sriharjo, dusun Mojohuro yang terdiri dari 6 RT dengan jumlah penduduk 857 jiwa dan 264 kepala keluarga dengan menggunakan purposive sampling maka terpilih 1 informan kunci dan 3 informan pendukung.Penelitian ini mengunakan 2 jenis sumber data yakni data primer dan data sekunder, Data primer merupakan data yang diperoleh dengan cara observasi dan wawancara. Data sekunder merupakan data yang diperoleh dengan cara mengkaji dokumen. Teknik analisis data menggunakan teori interaktif miles Huberman. Keabsahan data menggunakan triangulasi sumber dan teknik. Hasil penelitian menunjukkan bahwa tradisi yang berkembang dalam masyarakat Mojohuro, Sriharjo dapat di kelompokkan menjadi 3 hal yakni: 1) Tradisi yang terkait langsung dengan alam. 2) Tradisi yang terkait dengan tahap perkembangan kehidupan manusia. 3) Tradisi yang berasal dari lokal.
Early Prediction of Unplanned 30-Day Hospital Readmission: Model Development and Retrospective Data Analysis
Authors: Zhao Peng , Yoo Illhoi , Naqvi Syed H
Published: March 2021

Background

Existing readmission reduction solutions tend to focus on complementing inpatient care with enhanced care transition and postdischarge interventions. These solutions are initiated near or after discharge, when clinicians’ impact on inpatient care is ending. Preventive intervention during hospitalization is an underexplored area that holds potential for reducing readmission risk. However, it is challenging to predict readmission risk at the early stage of hospitalization because few data are available.

Objective

The objective of this study was to build an early prediction model of unplanned 30-day hospital readmission using a large and diverse sample. We were also interested in identifying novel readmission risk factors and protective factors.

Methods

We extracted the medical records of 96,550 patients in 205 participating Cerner client hospitals across four US census regions in 2016 from the Health Facts database. The model was built with index admission data that can become available within 24 hours and data from previous encounters up to 1 year before the index admission. The candidate models were evaluated for performance, timeliness, and generalizability. Multivariate logistic regression analysis was used to identify readmission risk factors and protective factors.

Results

We developed six candidate readmission models with different machine learning algorithms. The best performing model of extreme gradient boosting (XGBoost) achieved an area under the receiver operating characteristic curve of 0.753 on the development data set and 0.742 on the validation data set. By multivariate logistic regression analysis, we identified 14 risk factors and 2 protective factors of readmission that have never been reported.

Conclusions

The performance of our model is better than that of the most widely used models in US health care settings. This model can help clinicians identify readmission risk at the early stage of hospitalization so that they can pay extra attention during the care process of high-risk patients. The 14 novel risk factors and 2 novel protective factors can aid understanding of the factors associated with readmission.
Uncovered Interest Parity and Expected Depreciation in a Dollarized Cambodian Economy
Authors: Chanthol Hay
Published: March 2021

This paper tests the Uncovered Interest Parity (UIP) for Cambodian economy using the Generalized Methods of Moment (GMM). GMM method is used to address the weak result of simple OLS method, including the problems of endoneneity, serial correlation, heteroskedasticity. The result showed that, during the period of exchange rate stability, UIP is not valid even the country is a very highly dollarized economy and people can save in both local currency and USD in domestic banks. The UIP coefficient is negative and significant for three-month and six-month interest rates. The negative coefficient suggests that the monetary policy that tries to decrease interest rate (increase) may face the risk of currency depreciation (appreciation). If local currency depreciation is the driving force of dollarization, reducing local interest rate will encourage more dollarization in the economy.
A Learning Opportunity by TVOntario
Authors: May Steven James
Published: March 2021

Background:Sparked by a short-lived plan by the Ontario Educational Communications Authority (known as TVOntario or TVO) to reduce its slate of nine digital over-the-air transmitters to a single transmitter broadcasting from Toronto’s CN Tower, this article questions why some viewers continue to rely on TVO’s transmitters for access.

Analysis:This article provides analysis of findings from a 2018 study regarding the role that TVO’s transmitters play in the provision of access to its programming.

Conclusion and implications:Analysis of the viewing experiences shared by the research participants identifies four access themes related to infrastructure concerns, monetary concerns, educational concerns, and geographic concerns outside of the Greater Toronto Area.
Viewboard Jadwal Persiapan Sidang Pada Sistem PESSTA+ Menggunakan YII Framework di Perguruan Tinggi
Authors: Rahardja Untung , Handayani Indri , Elinda Bella Dhea
Published: March 2021

Informasi penilaian sidang skripsi dan tugas akhir merupakan sistem informasi yang disediakan untuk mahasiswa menyajikan informasi yang dapat diakses secara online melalui website, tetapi terdapat beberapa kendala yang dihadapi oleh mahasiswa yang salah satunya yaitu tidak adanya Dashboard mengenai persiapan sidang yang berisikan jadwal berjalannya sidang mahasiswa, penilaian objektif dan penilaian pembimbing saat ini masih dalam tahap percobaan. Pada penelitian ini Dashboard digunakan sebagai sistem memonitoring penjadwalan sidang TA/Skripsi. Penjadwalan sidang TA/Skripsi, penilaian objektif dan penilaian pembimbing sering kali menjadi kendala bagi mahasiswa, dan ketua panitia sidang sebab, mahasiswa harus datang ke kampus untuk mengetahui jadwal sidang dan nilai yang di dapat dari pembimbing dan bagi ketua panitia yang ingin memantau perkembangan mengenai persiapan sidang. Metode penelitian yang digunakan yaitu pengumpulan data dari proses penjadwalan sidang dan penilaian yang nantinya akan diterapkan pada PESSTA+ ( Penilaian Sidang Skripsi dan Tugas Akhir Plus ) yang dapat diakses secara online untuk memudahkan mahasiswa dan ketua panitia sidang.
Sistem Penunjang Keputusan Menggunakan Metode Promethee Dalam Pemilihan Mobil sesuai kebutuhan Pelanggan
Authors: Aini Nurul , Hasmin Erfan
Published: March 2021

Abstract-
Semakin tingginya tingkat mobilitas setiap orang yang menuntut untuk memiliki alat transportasi pribadi guna memperlancar aktivitas sehari-hari. Mobil merupakan salah satu alat transportasi pribadi yang digemari karena selain memiliki tingkat kenyamanan yang tinggi, memiliki mobil pribadi dianggap sebagian orang sebagai suatu ke banggan tersendiri. Semakin banyaknya tipe dan jenis mobil dengan keunggula n dan kekurangan masing-masing tak jarang membuat orang yang ingin membeli mobil mengalami kesulitan menentukan pilihan mobil yang sesuai dengan kebutuhan dan keinginan mereka. Untuk itu, diperlukan suatu sistem pendu kung keputusan yang dapat memberikan rekomendasi pilihan mobil yang sesuai dengan keinginan dan kebutuhan. Sistem Pendukung Keputusan (SPK) ini menggunakan metode PROMETHEE ( Preference Ranking Organization Method for Enrichment Evalution ). PROMETHEE adalah suatu metode penentuan urutan (prioritas) dalam analisis multikriteria. Dengan adanya aplikasi Sistem pendukung keputusan pemilihan mobil menggunakan metode PROMETHEE ini dapat membantu para calon pembeli mobil dalam menentukan pilihan yang sesuai dengan kebutuhan mereka.
Analisa Sentimen Dengan Korpus Sentiment140 Menggunakan Classifier Support Vector Machine RBF
Authors: Dharsono Yulius Paulus
Published: March 2021

Studi dan strategi dalam penekanan laju penyebaran pandemi COVID-19 pernah dilakukan negara Singapura, pada masa epidemi SARS-CoV varian virus novel corona dengan menerapkan kebijakan pembatasan sosial. Hal ini menjadi topik tren pada tagar jejaring sosial Twitter. Banyaknya pengguna dan kecepatan respon terhadap situasi dan kondisi lingkungan, menjadikan Twitter sebagai sumber data besar opini potensial berupa informasi subyektif yang memiliki sentimen. Dalam hal ini, bagaimana opini dapat ditransformasi menjadi pengetahun terstruktur yang memiliki nilai dan dapat diterapkan secara praktis, menjadi menarik untuk dilakukan penelitian. Pendekatan penelitian dilakukan dengan mengadopsi label sentimen Twitter sebagai input pembuatan model pembelajaran mesin diawasi terhadap opini publik terkini. Fokus penelitian adalah analisa sentimen dataset berlabel Sentiment140, dengan data pengujian tweet tagar #socialdistancing menggunakan classifier SVM RBF. Hasil pengujian model classifier SVM RBF terhadap data pengujian 1116 tweet dengan prediksi sentimen pada uji1 77.51% positif dan uji2 63.97% positif. Dari kedua pengujian terdapat metrik dominan pada uji2, dengan nilai precision 72.83%. Secara umum parameter terbaik pengujian model terdapat pada keseimbangan antara precision dan recall, yakni F-measure dengan 70.57% pada uji1 dan 70.77% pada uji2.
Autotrophic and heterotrophic contributions to soil respiration in a subtropical camphor tree forest
Authors: Yan Wende , Peng Yuanying , Zheng Wei , Chen Xiaoyong
Published: March 2021

Understanding the contributions of autotrophic respiration (Ra) and
heterotrophic respiration (Rh) to total soil respiration (Rs) is
necessary for accurate prediction of global carbon balance and net
ecosystem production under environmental change. In this research,
annual Rs and Rh and estimated were investigated by using a root
trenching experiment in a Camphor tree (Cinnamomum camphora) forest in
subtropical China for two years to qualify the relative contribution of
Ra and Rh components to Rs, and to determine the environmental factors
that control the seasonal changes in Ra, Rh and Rs. The results showed
that annual mean Rs was 405 ± 219 gC m-2 year-1 in the studied forests,
of which Rh and Ra were 240 ± 120 gC m-2 year-1 and 164 ±102 gC m-2
year-1, respectively. The contribution of Rh to Rs averaged 58.1%,
ranging from 45 to 81%. The seasonal changes in Rs and Rh were highly
correlated with soil temperature, but not to soil water content. Our
results suggest microbial community and activity make a primary
contribution to carbon flux released from soil to atmosphere in the
studied forest ecosystems.
ANALISIS BUTIR SOAL DAN KEMAMPUAN SISWA DALAM MENJAWAB SOAL UJIAN NASIONAL PADA MATA PELAJARAN EKONOMI
Authors: Riani Dini , Almujab Saiful
Published: March 2021

Penelitian ini bertujuan untuk menganalisis sejauh mana butir-butir soal dalam soal Ujian Nasional mata pelajaran ekonomi tahun ajaran 2016/2017 mampu mengarahkan siswa-siswa di SMA Pasundan se-Bandung pada pengembangan berpikir tingkat tinggi. Analisis tersebut dilakukan dengan melihat karakteristik soal ujian nasional kemudian dilakukan pengkatagorisasian berdasarkan ranah kognitif Bloom. Sedangkan untuk analisis butir soal, peneliti melakukan analisis jawaban siswa untuk menentukan bagaiman tingkat kesukaran, daya pembeda dan efektifitas pengecoh pada soal UN. Dalam penelitian ini, peneliti juga melakukan analisis terhadap kemampuan siswa dalam menjawab soal-soal UN dengan menentukan jenis soal mana saja yang dianggap sulit berdasarkan jawaban yang dihasilkan. Metode penelitian yang digunakan adalah deskriptif kuantitatif, sedangakan data diolah mengunakan ANATES V.4. untuk kemudian ditarik kesimpulan. Hasil penelitian diharapkan dapat memberikan kontribusi bagi manajemen sekolah dan guru-guru ekonomi dalam mengembangkan materi pembelajaran yang mengarahkan pada kecakapan siswa dalam menjawab soal-soal yang terdapat di Ujian Nasional. Hasil penelitian menunjukan bahwa masih terdapat soal-soal dalam ujian nasonal khususnya pada mata pelajaran ekonomi yang perlu dilakukan evaluasi ulang karena memiliki kategori soal yang buruk.
COMPOSIÇÃO DA ICTIOFAUNA DO CÓRREGO BEBEDOURO (FRUTAL, MG) E SUA RELAÇÃO COM FATORES AMBIENTAIS
Authors: Lima Júlio César dos Santos , Biagioni Renata Cassemiro , Da Cunha Cristiano Pereira , Cerqueira Vitor Loreno de Almeida , Vaz Ariane Almeida , Vaz Adriane Almeida , Machado Cleber Coelho , Brito Sofia Luiza , Brito Tânia Aparecida da Silva , Smith Welber Senteio
Published: March 2021

A ictiofauna de riachos na região Neotropical ainda não é totalmente conhecida, sendo dados sobre a composição e distribuição de espécies incipientes. Este estudo objetivou investigar a composição da ictiofauna do córrego Bebedouro (Frutal - MG), de forma a contribuir no conhecimento da riqueza e distribuição de espécies no sudeste do Brasil. As amostragens foram realizadas no período seco (setembro/2012) e no período chuvoso (março de 2013), utilizando diferentes técnicas de pesca, em três trechos do córrego caracterizados quanto a diferentes parâmetros ambientais, limnológicos e de estrutura de habitat. Foram capturados 677 indivíduos de 50 espécies (45 são nativas e cinco não-nativas) distribuídas em seis ordens, sendo 239 no período chuvoso e 438 no período seco. As abundâncias das espécies entre os trechos em um mesmo período e entre os períodos não apresentaram diferenças significativas. A análise do protocolo de avaliação aplicado salientou que o córrego apresenta trechos com características de impacto antrópicos e naturais. Nossa hipótese de que a composição da comunidade de peixes não é homogênea ao longo dos trechos amostrados foi confirmada e observamos que a complexidade das espécies aumenta dos trechos à montante em direção à jusante.
تغير المعادلات الأمنية في ظل إستراتيجية أمن الطاقة
Authors: Mohammed Shallaw A. , Aqrawi Najdat S.
Published: March 2021

في الوقت الحاضر، يعتبر عامل الطاقة أحد أهم العوامل الجيوبوليتيكية التي تؤثر على أمن واستقرار مناطق مختلفة من العالم، ولاسيما تلك الغنية بالنفط والغاز الطبيعي. لذلك، يدور هذا البحث حول إظهار طبيعة العلاقة بين مصلحة الطاقة والتغيرات التي تحصل  في المعادلات الأمنية للدول بسبب الطاقة، وهو ما يؤثر بدوره على خلق حالة من الاستقرار واللاإستقرار الأمني للبلدان المصدرة والموردة للطاقة. من خلال هذا البحث، نتجاوز الدراسات الحديثة الأخرى حول هذا الموضوع، ونربط أهم عناصر أمن الطاقة بالمعادلات الإستقرار وللا استقرار للدول المصدرة والموردة للطاقة. وبالتالي، فإننا نحلل ما يدفع الدول المصدرة والموردة للطاقة بأن تؤثر على ديناميات تغير المعادلات الأمنية من أجل تأمين المصلحة الطاقوية لبلادهم. الى أن توصل البحث في ختامه الى هذه الحقيقة وهي، رغم نجاح بعض الدول في استخدام الطاقة كقوة صلبة لضمان الاستقرار الأمني لبلدانهم، فأنه بصورة عامة الدول المصدرة والموردة للطاقة ومن أجل تأمين أمن الطاقة، غيروا معادلاتهم الأمنية، وهذا أدى إلى خلق حالة من اللاإستقرار الأمني للدول على المستويات الوطنية والإقليمية وحتى الدولية.
Adolescencia e intimidades: narrativas en transición
Authors: Nava-Preciado José María
Published: March 2021

El autor explora en este artículo las valoraciones de los/as adolescentes acerca de la intimidad y analiza, a partir de ellas, cómo se configuran y se implican las relaciones afectivas en la actualidad. Enmarcada en el paradigma interpretativo, la investigación recupera el trabajo de campo realizado mediante grupos de discusión y entrevistas semiestructuradas con estudiantes de escuelas preparatorias de la Zona Metropolitana de Guadalajara, México. Los relatos obtenidos sugieren que las relaciones íntimas se tejen, en gran parte, alrededor de las redes sociales, lo que provoca el ensayo de tramas narrativas que sustituyen los relatos dominantes que durante mucho tiempo se posicionaron como infalibles y como únicos para organizar los modos de vivir las intimidades.
Analisis Kreatif Ide dan Pesan (Studi Kasus Terhadap TVC “Instagram Boyfriend” Ichi Ocha)
Authors: Setiawan Clara Cahya Octaviani , Sukendro Gregorius Genep
Published: March 2021

Television is a medium that still diverts advertising spending from media convergence to digital. There are many advantages of advertising on television, as well as their shortcomings. One drawback is the free control of the audience to change channels. Therefore, it is important for advertisers to ensure that their ads generate a special appeal so that the audience is interested in watching. Two important things that make an ad interesting are the ideas and the message. A 'creative' idea has five important components, namely a strong strategy, a strong sales idea, always relevant, stands out, and can be built into the campaign. The message that is 'creative' has three important points, namely stopping power, striking power, and sticking power. In this case, ideas and messages in an advertisement have a related and complementary relationship with each other. Ideas and messages are mutually sustainable. In this context, the important thing to consider in creating an advertisement is not to get one of the ideas or messages dominate and cover the other.Televisi adalah media yang masih mendominasi belanja iklan terlepas dari konvergensi media ke arah digital. Ada banyak kelebihan dari pemasangan iklan di televisi, begitu pula kekurangannya. Salah satu kekurangannya adalah kontrol bebas audiens untuk mengganti saluran. Oleh karena itu, penting bagi pemasang iklan untuk memastikan bahwa iklan mereka produksi memiliki daya tarik tersendiri agar audiens tertarik untuk menyaksikannya. Dua hal penting yang membuat iklan menarik adalah ide dan pesannya. Ide yang ‘kreatif’ memiliki lima komponen penting, yaitu potent strategy, strong selling idea, always relevant, stands out, dan can be built into campaign. Pesan yang ‘kreatif’ memiliki tiga poin penting, yaitu stopping power, striking power, dan sticking power. Dalam hal ini, ide dan pesan dalam sebuah iklan memiliki hubungan yang berkaitan dan saling melengkapi satu sama lain. Ide dan pesan saling berkesinambungan satu sama lain. Dalam konteks ini, hal yang penting untuk diperhatikan dalam membuat sebuah iklan adalah jangan sampai salah satu ide atau pesan tersebut mendominasi dan menutup satu dan yang lainnya.
SISTEM MONITORING ENERGI LISTRIK PADA KOMPOR PENGHASIL LISTRIK DENGAN TEKNOLOGI INTERNET OF THINGS (KOLISS-IOT
Authors: Faleva Muhammad Reza , Santoso Dian Budhi , Nurpulaela Lela
Published: March 2021

Listrik sudah menjadi kebutuhan dasar masyarakat saat ini. Sumber energi alternatif merupakan salah satu cara untuk membantu masyarakat dalam menyediakan energi listrik, oleh karena itu dibutuhkannya sebuah teknologi kompor penghasil listrik berbasis internet of things (KOLISS-IoT). Dibutuhkan alat monitoring agar diketahui berapa besar kinerja teknologi KOLISS-IoT dalam menghasilkan energi listrik Alat yang dirancang untuk memonitor ini dibutuhkan sensor tegangan dan arus, serta arduino. Sensor arus menggunakan sensor INA219 yang berfungsi untuk mendeteksi berapa besar arus tegangan dan daya dihasilkan oleh KOLISS-IoT. Serta dibutukan arduino dan module ESP8266 untuk mengolah data dan mengirim data menggunakan teknologi IoT. Hasilnya dapat ditampilkan pada lcd 16x2 I2C dan webpage menggunakan modul ESP8266. Hasil pengujian yang didapat melalui pengukuran menggunakan sensor tegangan, arus, dan daya oleh sensor INA219 yaitu pada rata-rata sebesar 2,65V pada perhitungan tegangan, 0,031A pada perhitungan arus dan 0,0785W pada perhitungan daya. Nilai maksimal tegangan, arus dan daya pada pengujian yaitu sebesar 2,85 V, 0,068A, dan 0,194W.
Multipartite entanglement in XOR games
Authors: Briet Jop , Buhrman Harry , Lee Troy , Vidick Thomas
Published: March 2021

We study multipartite entanglement in the context of XOR games. In particular, we study the ratio of the entangled and classical \emph{biases}, which measure the maximum advantage of a quantum or classical strategy over a uniformly random strategy. For the case of two-player XOR games, Tsirelson proved that this ratio is upper bounded by the celebrated Grothendieck constant. In contrast, \PG proved the existence of entangled states that give quantum players an unbounded advantage over classical players in a three-player XOR game. We show that the multipartite entangled states that are most often seen in today's literature can only lead to a bias that is a constant factor larger than the classical bias. These states include GHZ states, any state local-unitarily equivalent to combinations of GHZ and maximally entangled states shared between different subsets of the players (e.g., stabilizer states), as well as generalizations of GHZ states of the form $\sum_i \alpha_i \ket{i}\cdots\ket{i}$ for arbitrary amplitudes $\alpha_i$. Our results have the following surprising consequence: \emph{classical} three-player XOR games do not follow an XOR parallel repetition theorem, even a very weak one. Besides this, we discuss implications of our results for communication complexity and hardness of approximation. Our proofs are based on novel applications of extensions of Grothendieck's inequality, due to Blei and Tonge, and Carne, generalizing Tsirelson's use of Grothendieck's inequality to bound the bias of two-player XOR games.
Quantum discord and quantum phase transition in spin-1/2 frustrated Heisenberg chain
Authors: Fan Chu-Hui , Xiong Heng-Na , Huang Yixiao , Sun Zhe
Published: March 2021

By using the concept of the quantum discord (QD), we study the spin-1/2 antiferromagnetic Heisenberg chain with next-nearest-neighbor interaction. Due to the $SU(2)$ symmetry and $Z_{2}$ symmetry in this system, we obtain the analytical result of the QD and its geometric measure (GMQD), which is determined by the two-site correlators. For the 4-site and 6-site cases, the connection between GMQD (QD) and the eigenenergies was revealed. From the analytical and numerical results, we find GMQD (QD) is an effective tool in detecting the both the first-order and the infinite-order quantum-phase-transition points for the finite-size systems. Moreover, by using the entanglement excitation energy and a universal frustration measure we consider the frustration properties of the system and find a nonlinear dependence of the GMQD on the frustration.