bluuebunny/crossref_metadata_2025 huggingface dataset:
Gadolinium-based contrast agents for imaging of the central nervous system: A multicenter European prospective study
Authors: Heshmatzadeh Behzadi Ashkan , McDonald Jennifer
Published: August 2022

Contrast-enhanced MR (CE-MR) imaging is required to improve lesion detection and characterization and to increase diagnostic confidence. This study aims to evaluate the safety, effectiveness, and usage patterns of recently introduced ClariscanTM (gadoterate meglumine) and other macrocyclic gadolinium-based contrast agents (GBCAs) used for magnetic resonance imaging (MRI) of the central nervous system (CNS). Data was obtained from a European multicenter, prospective, observational postmarketing study that included pediatric and adult patients undergoing contrast-enhanced MRI with a GBCA used in routine clinical practice. Safety data was collected by spontaneous patient adverse event (AE) reporting. Effectiveness was assessed via changes in radiological diagnosis, diagnostic confidence, and image quality. 766 patients with CNS-related indications were included from 8 centers across 5 European countries between December 2018 and November 2019. Clariscan (gadoterate meglumine) was used in 66% (503) of exams, Dotarem® (gadoterate meglumine) in 20% (160), Gadovist® (gadobutrol) in 13% (97), and ProHance® (gadoteridol) in 1%. GBCA use increased the diagnostic confidence in 95% (724/766) of patients and a change in radiological diagnosis in 65% (501/766) of patients. The Clariscan-specific data revealed an increase in diagnostic confidence in 94% (472/503) of patients and resulted in a change in radiological diagnosis in 58% (293/503) of patients. Image quality was considered excellent or good in 95% of patients across all GBCAs and in 94% of patients who received Clariscan. No AEs were reported in this cohort including Clariscan. This data demonstrates the excellent safety and efficacy profile of Clariscan and other GBCAs used in MRI examination of the CNS.
Exercise training for cognitive and physical function in patients with mild cognitive impairment: A PRISMA-compliant systematic review and meta-analysis
Authors: Zhou Yue , Li Liang-da
Published: August 2022

Background:

This systematic review evaluates the effect of exercise training in the treatment of patients with mild cognitive impairment (MCI).

Methods:

PubMed, Medline, EMBASE, Web of Science, and Cochrane Library databases were systematically searched up to Oct 2021 in order to identify randomized controlled trials (RCTs) which evaluated the effects of physical exercise in persons with MCI. Changes of cognitive and physical function were tested using pre- and postMMSE and TUG scores, and were compared with control intervention.

Results:

A total of 10 RCTs involving 635 MCI patients were included in the meta-analysis. Physical exercise improved MMSE scores (MD 0.71, 95 % CI 0.57 to 0.85, P < .00001, I2 = 95 %) and TUG performance (MD −0.82, 95 % CI −1.20 to −0.45, P < .00001, I2 = 12 %) in patients with MCI.

Conclusions:

This meta-analysis demonstrated a positive effect of exercise training in people with MCI in relation to cognitive and physical function. These findings suggest exercise interventions be persistent, and reveal that more high-quality researches are needed.
Risk factors for frailty in older adults
Authors: Wang Xinrui , Hu Jiji , Wu Diping
Published: August 2022

Aims:

To clarify the risk factors for frailty to help doctors prevent diseases that cause weakness, through early interventions.

Methods:

We searched the PubMed, EMBASE, and Cochrane Library databases to identify all relevant studies using the items “frailty,” “weak,” “risk factors,” and “predictive factors” and compared their results. The aging population (≥65 years old) was divided into 2 groups, a “frailty group” and a “robust control group,” and then the characteristics, lifestyles, and comorbidities were compared.

Results:

We compared the influence of baseline and concomitant diseases on frailty in the elderly respectively, and the analysis of the influence of baseline on frailty found that increasing age, lower weight, female sex, living alone, low levels of exercise, polypharmacy, higher education level, smoking, drinking, malnutrition, and lower vitamin D levels were associated with aging individuals being more likely to experience frailty. The data about concomitant diseases had shown that diabetes, hearing dysfunction, cognitive impairment, poor sleep, a history of falls, pain, and depression can increase the risk of frailty among the elderly population.

Conclusion:

Characteristics, comorbidities, and lifestyle factors can impact the occurrence of frailty, and relevant influencing factors should be considered.
Expression characteristics of the yes-associated protein in breast cancer: A meta-analysis
Authors: Li Lan , Luo Jin , Fang Jing-Yi , Zhang Rui , Ma Jian-Bo , Zhu Zheng-Peng
Published: August 2022

Background:

The yes-associated protein (YAP) gene plays an important role in many malignant tumors, but its clinical significance in breast cancer remains unclear. This study aimed to explore the significance of YAP expression in breast cancer using meta-analysis.

Methods:

Seven databases will be searched to collect the case–control studies published on the association between YAP expression and clinical pathogenic features in breast cancer until December 2021: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wan Fang Database, and the Chinese Biomedical Literature Database. To perform meta-analysis, STATA 14.0 and RevMan5 software were used with odds ratio (OR) and 95% confidence interval (95% CI) as the effect index, and publication bias and sensitivity analysis were subsequently tested.

Results:

Form a total of 10 articles used in this study, 8 studies consisted of nontriple negative breast cancer (non-TNBC) and the other 2 of TNBC. Meta-analysis indicated a positive expression rate of YAP in non-TNBC tissues that was lower than in normal breast tissue (OR = 0.15, 95% CI = 0.10–0.21, P < .001). In contrast, the positive rate of YAP expression in TNBC was significantly higher than that in normal breast tissue (OR = 18.23, 95% CI = 8.20–40.52, P < .001). Furthermore, the positive expression rate was higher in the patients with lymph node metastasis, higher tumor node metastasis stage and histologic grade, and larger diameter in TNBC. However, there was no statistical difference in the positive expression rate of YAP between non-TNBC patients and lymph node metastasis, tumor node metastasis stage, histologic grade, and tumor size.

Conclusions:

YAP may participate in the occurrence and development of non-TNBC as a tumor suppressor gene; however, it may also be a carcinogenic factor in TNBC and may be a potential therapeutic target for TNBC.
Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study
Authors: Wu E. , Ni Jun-Tao , Xie Tian , Tao Lin
Published: August 2022

Depression has been associated with colorectal cancer (CRC) in observational studies. However, the causality of depression on CRC risk remained unknown. This study aimed to evaluate the potential causal association between genetic variants related to depression and the risk of CRC using Mendelian randomization (MR). Two-sample MR analysis using summary data was performed to examine whether depression was causally associated with CRC risk. We used 2 sets of instrumental variables (IV) from the genome-wide association study results for analysis. A set of IV related to major depressive disorder contain 44 single-nucleotide polymorphisms. Another set of IV was related to major depression, including 53 single-nucleotide polymorphisms. Summary data of CRC was from the FinnGen consortium. Based on the results of MR using inverse-variance weighted method, we found that genetically determined major depressive disorder (odds ratio = 1.06, 95% confidence interval = 0.77–1.45) or major depression (odds ratio = 0.77, 95% confidence interval = 0.57–1.04) did not causally increase CRC risk. The results of MR-Egger and the weighted median method are consistent with the inverse-variance weighted method. The two-sample MR analysis showed that depression is not causally associated with CRC risk. Further research is needed to investigate the association between depression and CRC.
Evaluation of MRI-based radiomic features in heart morphologic variations as a consequence of autoimmune thyroid disorders
Authors: Barachini Oliver , Schaer Michaela , Mirzaei Siroos , Hergan Klaus , Zandieh Shahin
Published: August 2022

Radiomics (RC) was initially developed using computed tomography (CT) for oncological imaging. However, it can be applied to various scientific and clinical radiology fields regardless of the modalities involved. The purpose of this survey was to evaluate alterations in magnetic resonance imaging of the heart (CMR) in patients suffering from autoimmune thyroid disorders (AITD) by applying RC tools and mapping features. A total of 50 individuals were evaluated in this study. We searched for CMR examinations performed in our department between January 2019 and 2021 in patients with AITD. Thirty patients with AITD (21 men and 9 women, aged 51 to 78 years; mean age, 60 years) were enrolled in our survey. We enrolled a control group (CG) of 20 individuals (14 men and 6 women aged 53–87 years; mean age, 68 years) without AITD or cardiac disorders. Global native T1 and T2 mapping revealed no significant differences between groups. However, we identified significantly higher values of several texture parameters, including the gray-level co-occurrence matrix (GLCM) entropy, gray-level run-length matrix (GLRLM; short-run high gray-level emphasis (SRHGE), GLCM (Energy), gray-level size zone matrix length matrix (GLZLM; LZLGE), GLZLM (SZLGE), DISCRETIZED (HISTO-Energy) GLCM (Dissimilarity), and GLCM (Contrast), in patients with AITD in comparison to the CG (P < .01). Our results indicate that several RC properties extracted from CMR images can be used to discriminate between the AITD and CG groups.
Ulcerative colitis-associated bronchiectasis: A rare extraintestinal manifestation of inflammatory bowel disease: A case report
Authors: Alhalabi Marouf , Ali Deeb Sawsan , Ali Fadwa , Abbas Ahmad
Published: August 2022

Rationale:

Inflammatory bowel disease patients may suffer from extraintestinal manifestations. Although muscles, joints, and skin are the most commonly affected, respiratory involvement is more prevalent than previously believed, and the majority of these patients have no symptoms. Although the large airways are the most frequently affected, the small airways, lung parenchyma, and pulmonary vasculature may also be affected.

Patient concerns:

A 24-year-old nonsmoking Syrian female was referred to the pulmonary medicine clinic in December 2020 due to a chronic cough. Her cough had been present for the last year, it was described as scratchy, and produced small amounts of mucoid sputum occasionally. She denied any related wheeze, hemoptysis, weight loss, or night sweats. Multiple courses of antibiotics were prescribed by many doctors, also previous chest radiographs were reported as normal. She was diagnosed with ulcerative colitis in 2012 after presentation with abdominal pain and per rectal bleeding. The diagnosis was confirmed via colonoscopy and colon biopsies, with no prior surgery. Her past medications included prednisone, mesalamine, azathioprine, and infliximab. Tests, including complete blood count, C-reactive protein (CRP), fecal calprotectin, and chest X-ray, were normal.

Diagnosis:

Ulcerative colitis-associated bronchiectasis was established through history and clinical examination beside pulmonary function test, which revealed a mild obstructive pattern, and a chest computed tomography follow-up that revealed bilateral bronchiectasis.

Interventions:

Bronchiectasis was treated with inhaled oral steroids and sputum expectoration while she continued mesalamine and azathioprine for ulcerative colitis.

Outcome:

Cough improvement and sustained ulcerative colitis remission.

Conclusions:

Identification of inflammatory bowel disease pulmonary exacerbation is probably poor, as pulmonary symptoms might emerge at any moment during the illness, and are most commonly diagnosed later in life and with the disassociation of inflammatory bowel disease activity. Pulmonologists should be involved in the care of inflammatory bowel disease patients who developed lung symptoms.
Exploring the clinical efficacy of different nonsurgical rehabilitation interventions for humeral lateral epicondylitis: A protocol for network meta-analysis
Authors: Wan Qing , Lan Qin , Zhi Fang , Lin Xingzhen
Published: August 2022

Background:

Lateral epicondylitis is a common musculoskeletal disorder characterized by the decreased grip and upper limb strength and pain in the lateral aspect of the elbow joint. At present, shock wave, corticosteroid injection, platelet-rich plasma injection, and Dextrose prolotherapy therapy nonsurgical rehabilitation treatment methods are commonly used in clinical. However, the conclusions of studies comparing treatment efficacy between them are controversial, with most studies focusing on limited comparisons and a lack of direct and indirect comparisons between them, making it difficult to have a clearer and more comprehensive understanding of the efficacy between them.

Purpose:

To comprehensively compare the effectiveness of shockwave, corticosteroid injection, platelet-rich plasma injection, and Dextrose prolotherapy therapy for the treatment of external humeral lateral epicondylitis using a reticulo-meta-analysis.

Methods:

Randomized controlled trials on the effectiveness of shock wave, corticosteroid injection, platelet-rich plasma injection, and Dextrose prolotherapy therapy for the treatment of external humeral lateral epicondylitis were searched in PubMed, The Cochrane Library, CNKI, and Wan-Fang databases for the period January 1, 2016 to January 1, 2021 for each database. Two investigators independently screened the literature, extracted data according to inclusion and exclusion criteria, and evaluated the quality of the literature in parallel. Statistical analyses were performed using Stata 14.0 software to compare differences in efficacy between treatment measures using ratio and 95% confidence interval as effect indicators and to rank efficacy.

Results:

Nine randomized controlled trials with a total of 289 patients with external humeral lateral epicondylitis were included, involving 4 nonsurgical rehabilitation measures and 6 intervention options. Quadrilateral ring to test the inconsistency of each closed-loop study finding, and the results show that the inconsistency factor was bounded at 1.65, with lower 95% confidence interval of 0.47 and 2.84 for both, which in summary indicates that the formation between the treatment measures in this study indicates that each closed-loop inconsistency was good. The SUCRA curve showed that platelet-rich plasma injection + shockwave was the first treatment with an area under the curve of 86.9%. Six treatment measures were ranked as follows: platelet-rich plasma injection + shockwave > platelet-rich plasma injection > shockwave > corticosteroid > corticosteroid + shockwave > prolotherapy.

Conclusions:

It is believed that in the course of clinical practice, platelet-rich plasma injection combined with shockwave therapy can be preferred for patients with humeral epicondylitis.
The growth rates and influencing factors of preterm and full-term infants: A birth cohort study
Authors: Zhonggui Xiong , Ping Zhang , Jian Ke , Feimin Sun , Zeyuan Xia
Published: August 2022

This study aimed to explore the growth rates and influencing factors of the length and weight of preterm and full-term infants in the urban areas of Hubei province to provide a reference for child health and related clinical fields. A birth cohort study was used to analyze the growth rates and influencing factors of the length and weight of preterm and full-term infants using a multivariate regression analysis. The growth rates of the length and weight of preterm infants were significantly lower than those of full-term infants from birth to 3 months of age (P < .05), and gradually caught up to the level of full-term infants after 3 months of age (P > .05). Meanwhile, there were some influencing factors that had significant differences by their contribution to the growth rates of the length and weight of preterm and full-term infants. This study proposed that perinatal factors were attached more importance to the growth rates of preterm infants in the urban areas of Hubei province.
High dose insulin therapy for inotropic support during veno-arterial extracorporeal membrane oxygenation decannulation: A case report
Authors: Shah Kartik R. , Przybysz Thomas M. , Ushakumari Deepu , Geib Ann-Jeannette
Published: August 2022

Rationale:

High-dose insulin (HDI) therapy has been used as inotropic support for toxin-induced cardiogenic shock, but literature suggests that it can also be used in non-toxin-induced cardiogenic shock states. Its use has not been reported in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) decannulation.

Patient concerns:

A 56-year-old male presented with progressive dyspnea and lower extremity edema without any reported toxic ingestion.

Diagnosis:

After left heart catheterization, he was diagnosed with acute biventricular nonischemic cardiac failure that ultimately required VA-ECMO support for 8 days, after which decannulation was planned.

Interventions:

During decannulation, he was initiated on HDI therapy via a 1 U/kg regular insulin bolus with 25 g of dextrose and a 1 U/kg/hr insulin infusion.

Outcomes:

During the decannulation, he was monitored with transesophageal echocardiography. Initially, left ventricular (LV) ejection fraction (EF) was estimated at 10% to 15%. Transesophageal echocardiography after HDI but prior to decannulation showed LVEF 30% to 40%. Transthoracic echocardiography 3.5 hours after HDI bolus and decannulation revealed normal LV systolic function; LVEF 50% to 55%.

Lessons:

While multiple interventions occurred during decannulation, HDI therapy may have assisted in transitioning off ECMO support, and HDI should be investigated as an adjunctive option in future decannulations and other non-toxin-induced cardiogenic shock states.
Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
Authors: Parvin Sultana , Islam Md. Samiul , Majumdar Touhidul Karim , Azam Md. Golam , Islam Mohammad Shohidul , Begum Most. Rokshana , Hossain Md. Altaf , Imam Iftekhar , Ahmed Faruque
Published: August 2022

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a dreaded complication. But the frequency of this complication varies widely (1%–40%) among the literature and across geographical regions. With uncertainty in the estimation of occurrence and having no accepted, safe, effective method to prevent it, identification of its frequency and predictable risk factors is very crucial in a local or regional setting. The aim of this study was to identify the frequency of PEP and its risk factors from 4 tertiary care referral centers from a country in the South East Asia Region. This cross-sectional study was done on 1042 consecutive ERCP in adult patients (age >18 years) with baseline serum amylase levels less than 3 times the upper level of standard value. On the basis of clinical features and the amylase level at 24 hours (the next morning), the procedure was evaluated to confirm PEP. The frequency of PEP was calculated and procedure, patient, or operator-related independent risk factors for occurring PEP were analyzed using univariate and multivariate analyses. The study found 204 (19.6%) cases of PEP. In multivariate regression analysis, young age, suspected Sphincter of Oddi Dysfunction, recurrent pancreatitis, needle papillotomy, and pancreatic sphincterotomy were significant risk factors. The univariate analysis also found difficult cannulation and pancreatic duct injection with contrast as significant risk factors. Both patient-related and procedure-related risk factors acted independently for the development of PEP, which occurred in 19.6% of cases. This multicenter assessment of the frequency and risk factors for PEP in our patients would be extremely beneficial for future prevention of this complication.
Comparison of olecranon osteotomy and paratricipital approach in distal humerus intra-articular fracture: A systematic review and meta-analysis
Authors: Jeong Ho-Seung , Yang Jae Young , Jeon Seung Jun , Shon Hyun-Chul , Oh Jong-Keon , Lim Eic Ju
Published: August 2022

Background:

Surgical outcomes of the paratricipital approach (PT) and olecranon osteotomy (OO) for the treatment of distal humerus intra-articular fracture have been reported. However, there is no consensus regarding which approach is better in terms of functional outcomes and complications. This study aimed to compare the operation time, functional outcomes, and complications of OO and PT.

Methods:

The databases of MEDLINE, Embase, and Cochrane Library were systematically searched for studies published before June 1, 2021. We performed synthetic analysis of the operation time, functional outcomes, and incidence of complication after the conduct of OO group or PT group in patients with distal humerus intra-articular fractures.

Results:

Five studies were included representing a total of 243 patients who underwent surgery for distal humerus intra-articular fractures. A pooled analysis showed that there was a longer operation time in the OO group compared with the PT group (mean difference [MD] = 13.32, 95% CI: 3.78–22.87; P = .006). There was no significant difference between the functional outcomes of the OO and PT groups (elbow flexion: MD = 2.4, 95% CI: −0.82 to 5.79, P = .14; elbow extension: MD = 0.36, 95% CI: −2.20 to 2.92, P = .78; elbow arc of motion: MD = 0.40, 95% CI: −4.05 to 4.84, P = .86; Mayo Elbow Performance score: MD = −1.37, 95% CI: −4.73 to 1.98, P = .42). The incidence of infection was significantly higher in the OO group compared with that of the PT group (odds ratio [OR] = 3.82, 95% CI: 1.03–14.16, P = .04). There was no significant difference between the 2 groups in terms of the heterotopic ossification and ulnar neuropathy (OR = 1.85, 95% CI: 0.51–6.71, P = .35 and OR = 2.74, 95% CI: 0.60–12.48, P = .19, respectively).

Conclusions:

Since the choice of surgical approach does not influence outcomes, surgeons can base their choice of approach on the basis of their own experience and familiarity with the procedure and the need to visualize the entire articular surface in complex intra-articular fracture patterns.
Microsatellite instability/mismatch repair deficiency and activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland: A case report
Authors: Yang Guang
Published: August 2022

Rationale:

Gastric adenocarcinoma of the fundic gland is a rare, well-differentiated variant of gastric adenocarcinoma, which has been proposed as a novel disease entity. As a result of mismatch repair deficiency, microsatellite instability has been frequently observed in various human cancers and widely performed in the area of cancer pathogenesis. Herein, we report a case of gastric adenocarcinoma of fundic gland presented with microsatellite instability phenotype.

Patient concerns:

A 46-year-old man was referred to our hospital for abdominal distension and pain.

Diagnosis:

The patient contained 3 tumor lesions with different degrees of histologic differentiation and microsatellite instability. The lesions were located in the upper third of the stomach. The tumor size was 55 mm. Macroscopically, tumor showed an ulcerative type. In terms of depth of invasion, tumor lesion invaded into subserosa with lymphatic invasion. In addition, this patient did not present GNAS mutation but harbored AXIN2 mutation. By immunohistochemistry, the expression level of β-catenin protein in the nucleus of the carcinoma cells was obviously higher than that in normal nucleus. Compared with microsatellite instability-low lesion, PD-1, PD-L1, and CD8 were positive in the microsatellite instability-high lesions.

Interventions:

The patient underwent surgical resection and postoperative chemotherapy.

Outcomes:

The patient experienced distant metastasis and died from severe complications after 6 months of treatment.

Lessons:

These results suggested that the mutation of Wnt component genes associated with Wnt/β-catenin signaling pathway activation may play a role in promoting the occurrence of gastric adenocarcinoma of fundic gland. This is the first report of a gastric adenocarcinoma of fundic gland with microsatellite instability. These findings modify our understanding of the pathophysiology of gastric adenocarcinoma of fundic gland.
Thyroid storm complicated by corpus callosum infarction in a young patient: A case report and literature review
Authors: Cai Yunjia , Ren Linan , Liu Xinming , Li Chen , Gang Xiaokun , Wang Guixia
Published: August 2022

Rationale:

Thyroid storm (TS) is a rare life-threatening hypermetabolic thyrotoxicosis with an incidence of 0.57–0.76/100,000. The coexistence of TS and acute cerebral infarction is rare. Previous studies have shown that hyperthyroidism complicated by cerebral infarction mainly occurs in the intracranial basal ganglia; however, there are no reports of corpus callosum infarction. We report a case of TS complicated by cerebral infarction of the corpus callosum at our hospital.

Patient concerns:

A 31-year-old male patient with a history of hyperthyroidism was admitted to the hospital because of fatigue, palpitations, fever, and profuse sweating accompanied by a mild decrease in the muscle strength of the left limb. Diagnosis of a TS was confirmed by the laboratory test results. The patient’s clinical symptoms gradually improved after treatment. However, his left limb muscle strength progressively decreased, and the bilateral pathological signs were positive at the same time. Magnetic resonance imaging (MRI) of the head revealed acute cerebral infarction of the corpus callosum and pons.

Diagnosis:

The diagnosis was thyroid strom with acute cerebral infarction of the corpus callosum and pons and severe stenosis or occlusion of the basilar artery.

Interventions:

The patient was given 300 mg hydrocortisone intravenously per day, propylthiouracil tablets of 200 mg 3 times a day by nasal feeding, and 20 mg propranolol three times a day by nasal feeding. Aspirin and clopidogrel were administered to prevent platelet aggregation, and atorvastatin calcium was administered to lower lipid levels to stabilize plaques.

Outcomes:

The patient’s left limb muscle strength recovered to grade 4+, and he could walk beside the bed with support. Simultaneously, thyroid function was better than before.

Lessons:

Careful physical examination should be performed in patients with thyroid storm, and head imaging examination should be improved for the early detection of cerebral infarction.
Effects of nutritional supplement and resistance training for sarcopenia in patients with inflammatory bowel disease: A randomized controlled trial
Authors: Zhao Jiaxi , Huang Yiqin , Yu Xiaofeng
Published: August 2022

Background:

Nutritional supplementation and resistance training are broadly recommended as part of the treatment of sarcopenia, but studies that have evaluated interventions in inflammatory bowel disease patients with sarcopenia are lacking. The aim of this study was to evaluate the effects of nutritional supplementation and resistance training for improving height-adjusted appendicular skeletal muscle mass (ASM/H2) and medical indices in patients with inflammatory bowel disease.

Methods:

This randomized, double-blind, placebo-controlled trial of forty-five participants was performed at Huadong Hospital Affiliated to Fudan University in Shanghai from September 2020 to June 2021. Eligible participants were randomly assigned to receive whey protein (10 g/d) or placebo (10 g/d) for 8 weeks while completing a resistance training program (3 times a week). Data such as ASM/H2 and other medical indices were collected at baseline and at 4 and 8 weeks of intervention.

Results:

Fifteen participants were allocated to the resistance training and whey protein (RT+WP) group, and thirteen participants were allocated to the resistance training and placebo (RT+placebo) group. The ASM/H2 significantly increased in the RT+WP group after 4 and 8 weeks of intervention, and the ASM/H2 of the RT+WP group was significantly higher than that of the RT+placebo group after 4 and 8 weeks of intervention (F = 1.092, P = .035). Both interventions significantly increased albumin (F = 7.214, P = .003). Hemoglobin and creatinine significantly increased in the RT+WP group (F = 3.592, P = .035; F = 3.922, P = .033, respectively). In addition, a significant group × time interaction was not observed for body mass index, 5-time chair stand test time, 3-metre walk speed, grip strength, waist circumference, hip circumference, or waist-to-hip ratio (P > .05).

Conclusions:

Nutritional supplementation may be effective in improving sarcopenia, as well as many other physiological indicators during resistance training.
People With Functional Disability and Access to Health Care During the COVID-19 Pandemic
Authors: Xie Zhigang , Hong Young-Rock , Tanner Rebecca , Marlow Nicole M.
Published: August 2022

Introduction:

The COVID-19 pandemic and nationwide restriction measures have disrupted health care delivery and access for the general population. There is limited evidence about access to care issues (delayed and forgone care) due to the pandemic among people with disability (PWD).

Methods:

This study used the 2020 National Health Interview Survey data. Disability status was defined by disability severity (moderate and severe disability), type, and the number of disabling limitations. Descriptive analysis and multivariate logistic regression (adjusted for sociodemographic and health-related characteristics) were conducted to estimate delayed/forgone care (yes/no) between PWD and people without disability (PWoD).

Results:

Among 17,528 US adults, 40.7% reported living with disability. A higher proportion of respondents with severe and moderate disability reported delaying care than PWoD (severe=33.2%; moderate=27.5%; PWoD=20.0%, P<0.001). The same was true for forgone medical care (severe=26.6%; moderate=19.0%; PWoD=12.2%, P<0.001). Respondents with a moderate disability {delayed [odds ratio (OR)=1.33, 95% confidence interval (CI)=1.19, 1.49]; forgone [OR=1.46, 95% CI=1.28, 1.67]} and a severe disability [delayed (OR=1.52, 95% CI=1.27, 1.83); forgone (OR=1.84, 95% CI=1.49, 2.27)] were more likely to report delayed medical care and forgone medical care compared with PWoD. These findings were consistent across the models using disability type and the number of limitations.

Conclusions:

PWD were more likely to experience COVID-19-related delays in or forgone medical care compared with PWoD. The more severe and higher frequency of disabling limitations were associated with higher degrees of delayed and forgone medical care. Policymakers need to develop disability-inclusive responses to public health emergencies and postpandemic care provision among PWD.
Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification
Authors: Thompson Lester D.R. , Bishop Justin A.
Published: August 2022

Salivary gland intraductal carcinoma (IDC) is a very uncommon group of neoplasms. Many names, variations in diagnostic criteria, and newly observed molecular findings (including NCOA4::RET, TRIM27::RET, HRAS point mutations, and PIK3CA pathway alterations) have generated further confusion in being able to recognize and categorize this group of tumors. Different histologic appearances and patterns of growth suggest there is more than one tumor category, with intercalated duct, apocrine, oncocytic, and hybrid features seen. Frankly destructive invasion further complicates the category, as the name “intraductal” would suggest an “in situ” neoplasm. Recent evidence on fusion-positive IDC demonstrates the same molecular underpinnings in both the ductal and the myoepithelial cells, which aids in further separating these tumors. This article summarizes the historical group of 183 neoplasms classified under the umbrella of IDC and highlights the unique histologic, immunohistochemistry, and molecular features that may further guide nomenclature standardization and harmonization.
SARS-CoV-2 With Concurrent Respiratory Viral Infection as a Risk Factor for a Higher Level of Care in Hospitalized Pediatric Patients
Authors: Dikranian Lea , Barry Suzanne , Ata Ashar , Chiotos Katie , Gist Katja , Bhalala Utpal , Danesh Valerie , Heavner Smitty , Gharpure Varsha , Bjornstad Erica C. , Irby Olivia , Heneghan Julia A. , Montgomery Vicki , Gupta Neha , Miller Aaron , Walkey Allan , Tripathi Sandeep , Boman Karen , Bansal Vikas , Kumar Vishakha , Kashyap Rahul , Sayed Imran , Woll Christopher ,   From the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: COVID-19 Registry Investigator Group
Published: August 2022

Objective

As of early 2021, there have been over 3.5 million pediatric cases of SARS-CoV-2, including 292 pediatric deaths in the United States. Although most pediatric patients present with mild disease, they are still at risk for developing significant morbidity requiring hospitalization and intensive care unit (ICU) level of care. This study was performed to evaluate if the presence of concurrent respiratory viral infections in pediatric patients admitted to the hospital with SARS-CoV-2 was associated with an increased rate of ICU level of care.

Design

A multicenter, international, noninterventional, cross-sectional study using data provided through The Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study database.

Setting

The medical ward and ICU of 67 participating hospitals.

Patients

Pediatric patients younger than 18 years hospitalized with SARS-CoV-2.

Interventions

None.

Measurements and Main Results

A total of 922 patients were included. Among these patients, 391 required ICU level care and 31 had concurrent non–SARS-CoV-2 viral coinfection. In a multivariate analysis, after accounting for age, positive blood culture, positive sputum culture, preexisting chronic medical conditions, the presence of a viral respiratory coinfection was associated with need for ICU care (odds ratio, 3.6; 95% confidence interval, 1.6–9.4; P < 0.01).

Conclusions

This study demonstrates an association between concurrent SARS-CoV-2 infection with viral respiratory coinfection and the need for ICU care. Further research is needed to identify other risk factors that can be used to derive and validate a risk-stratification tool for disease severity in pediatric patients with SARS-CoV-2.
GPR183 targets lung-resident CD301b+ conventional dendritic cells type 2 to a subtissular TSLP – TSLP receptor mediated survival niche within the adventital cuff
Authors: Zhang L. , Yu J. , Spath S. , Sheoran S. , Bejarano D , Vandestienne M , Weier AK , Quast T. , Ibrahim M. , Reimer S , Uderhardt S , Mass E. , Hasenauer J. , Pfeifer A. , Kiermaier E. , Kolanus W. , Ziegler S. , Schlitzer A.
Published: August 2022

Conventional dendritic cells (cDCs) are strategically localized throughout non-lymphoid tissues. How such spatially regulated subtissular placement is achieved remains largely elusive. Here, we reveal that GPR183 targets CD301b+ cDC2 to a TSLP-dependent survival niche within the adventital cuff. We identified a close association of CD301b+ cDC2 with PDGFRα+ fibroblasts within the adventitial region of the lung. Genetic ablation of GPR183 within the cDC lineage leads to a selective loss of CD301b+ cDC2 in conjunction with the loss of CD301b+ cDC2 : fibroblast colocalization. Next bone marrow chimeric experiments and expression studies suggested adventitial fibroblasts as the main source of 7α,25 hydroxycholesterol, the natural ligand of GPR183. Single cell transcriptomic receptor ligand inference and subsequent genetic validation revealed TSLP receptor signalling as a crucial fibroblast derived CD301b+ cDC2 survival factor. These data expose a subtissular localization mechanism for tissue-specific functionalization of CD301b+ cDC2.
The interplay between metabolic stochasticity and regulation in singleE. colicells
Authors: Wehrens Martijn , Krah Laurens H.J. , Towbin Benjamin D. , Hermsen Rutger , Tans Sander J.
Published: August 2022

Metabolism is inherently stochastic at the cellular level. Whether cells actively regulate processes in response to these random internal variations is a fundamental problem that remains unaddressed, yet critical to understanding biological homeostasis. Here, we show that in E. coli cells, expression of the main catabolic enzymes is continuously adjusted in response to metabolic fluctuations under constant external conditions. This noise feedback is performed by the cAMP-CRP system, which controls transcription of the catabolic enzymes by modulating concentrations of the second messenger cAMP upon changes in metabolite abundance. Using time-lapse microscopy, genetic constructs that selectively disable cAMP-CRP noise feedback, and mathematical modelling, we show how fluctuations circulate through this hybrid metabolic-genetic network at sub cell-cycle timescales. This circulation of stochastic fluctuations is explained by four distinct noise propagation modes, one of which describes the continuous cAMP-CRP regulation. The model successfully predicts how noise circulation is impacted by C-sector under and over-expression. The results raise the question whether the cAMP-CRP system, as well as other metabolic regulation mechanisms, have evolved to manage internal metabolic fluctuations in addition to external growth conditions. We conjecture that second messengers may broadly function to control metabolic stochasticity and achieve cellular homeostasis.
ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells
Authors: Parejo-Alonso Beatriz , Royo-García Alba , Espiau-Romera Pilar , Courtois Sarah , Curiel-García Álvaro , Zagorac Sladjana , Villaoslada Isabel , Olive Kenneth P. , Heeschen Christopher , Sancho Patricia
Published: August 2022

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease characterized by its metastatic potential and chemoresistance. These traits are partially attributable to the highly tumorigenic pancreatic cancer stem cells (PaCSCs). Interestingly, these cells show unique features in order to sustain their identity and functionality, some of them amenable for therapeutic intervention. Screening of phospho-receptor tyrosine kinases revealed that PaCSCs harbored increased activation of anaplastic lymphoma kinase (ALK). We subsequently demonstrated that oncogenic ALK signaling drives tumorigenicity in PDAC patient-derived xenografts (PDXs) by promoting stemness through ligand-dependent activation. Indeed, the ALK ligands midkine (MDK) or pleiotrophin (PTN) increased self-renewal, clonogenicity and CSC frequency in several in vitro local and metastatic PDX models. Conversely, treatment with the clinically-approved ALK inhibitors Crizotinib and Ensartinib decreased CSC content and functionality in vitro and in vivo, by inducing cell death. Strikingly, ALK inhibitors sensitized chemoresistant PaCSCs to Gemcitabine, as the most used chemotherapeutic agent for PDAC treatment. Consequently, ALK inhibition delayed tumor relapse after chemotherapy in vivo by effectively decreasing the content of PaCSCs. In summary, our results demonstrate that targeting the MDK/PTN-ALK axis with clinically-approved inhibitors impairs in vivo tumorigenicity and chemoresistance in PDAC suggesting a new treatment approach to improve the long-term survival of PDAC patients.

GRAPHICAL ABSTRACT
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
Authors: Scinicariello Sara , Söderholm Adrian , Schäfer Markus , Shulkina Alexandra , Schwartz Irene , Hacker Kathrin , Gogova Rebeca , Kalis Robert Wolfgang , Froussios Kimon , Budroni Valentina , Bestehorn Annika , Clausen Tim , Kovarik Pavel , Zuber Johannes , Versteeg Gijs A.
Published: August 2022

Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay. A key but poorly understood mechanism of TTP regulation is its timely proteolytic removal: TTP is degraded by the proteasome through yet unidentified phosphorylation-controlled drivers. In this study, we set out to identify factors controlling TTP stability. Cellular assays showed that TTP is strongly lysine-ubiquitinated, which is required for its turnover. A genetic screen identified the ubiquitin E3 ligase HUWE1 as a strong regulator of TTP proteasomal degradation, which we found to control TTP stability indirectly by regulating its phosphorylation. Pharmacological assessment of multiple kinases revealed that HUWE1-regulated TTP phosphorylation and stability was independent of the previously characterized effects of MAPK-mediated S52/S178 phosphorylation. HUWE1 function was dependent on phosphatase and E3 ligase binding sites identified in the TTP C-terminus. Our findings indicate that while phosphorylation of S52/S178 is critical for TTP stabilization at earlier times after pro-inflammatory stimulation, phosphorylation of the TTP C-terminus controls its stability at later stages.
Genetic variance and indirect genetic effects for affiliative social behavior in a wild primate
Authors: McLean Emily M. , Moorad Jacob A. , Tung Jenny , Archie Elizabeth A. , Alberts Susan C.
Published: August 2022

Affiliative social behaviors are linked to fitness components in multiple species. However, the role of genetic variance in shaping affiliative social behaviors remains largely unknown, limiting our understanding of how these behaviors can respond to natural selection. Here, we employed the ‘animal model’ to estimate both environmental and genetic sources of variance and covariance in grooming behavior in the well-studied Amboseli baboon population in Kenya. We found that grooming given, grooming received, and total grooming all are similarly heritable (h2=0.22, h2=0.16, and h2=0.26 respectively), and that rank and the presence of kin contribute to environmental variance. We detected small but measurable indirect genetic effects of partner identity on the amount of grooming given within dyadic grooming partnerships. The genetic correlation between grooming given and grooming received was exceptionally strong and positive (R=0.94 ± 0.12), and the indirect and direct genetic effects for grooming given were also strongly positively correlated (R=0.86 ± 0.06). Our results provide insight into the evolvability of affiliative behavior in wild animals, including the possibility for correlations between direct and indirect genetic effects to accelerate the response to selection. As such they provide novel information about the genetic architecture of social behavior in nature, with important implications for the evolution of cooperation and reciprocity.
Rocking-curve imaging of high-quality protein crystals by non-dispersive X-ray optics in the double-crystal configuration
Authors: Suzuki Ryo , Abe Marina , Hirano Keiichi , Kojima Kenichi , Tachibana Masaru
Published: August 2022

The double-crystal configuration is useful for the evaluation of strain and defects in single crystals. In this study, rocking curve measurements by X-ray topography in the double-crystal configuration were demonstrated using perfect crystals of the protein glucose isomerase (GI). The setup enables precise evaluation of perfection in protein crystals with the nearly nondispersive X-ray optics. It reveals the uniform perfection of GI crystals according to the theory of X-ray diffraction. It is expected that unknown imperfections in various protein crystals of lower quality will be revealed by the nondispersive configuration using perfect protein crystals.
Earnings manipulation behavior in the banking industry of Bangladesh: the strategical implication of Beneish M-score model
Authors: Khatun Asia , Ghosh Ratan , Kabir Sadman
Published: August 2022

Purpose

This study aims to determine the number of companies involved in earnings manipulation. Additionally, this study has empirically investigated the common manipulation items among the companies.

Design/methodology/approach

Bangladesh's listed commercial banks are selected as a sample for this study, and financial data from 2009 to 2018 were collected. The likely and nonlikely manipulator Beneish model (1999) divides the sample into two groups. Based on the M-score of the model, the banks are put into two groups. To identify the most influential variables, an independent samplet-test was done with the help of Statistical Package for Social Sciences (SPSS).

Findings

The findings show that banks in Bangladesh have an unstable trend in making manipulated financial reports. Results of thet-test reveal that overstating revenues, increasing intangible assets, lessening cost and accruals are the most appealing items for preparing a fraudulent financial report. The findings of this research work will help the investors take the right decision having the idea of manipulation in the banking sector of Bangladesh.

Originality/value

In the presence of many irregularities in the banking sector Bangladesh, very few studies have been carried out in forensic accounting and fraudulent financial reporting practices. Much research has focused on earnings management techniques. This research specifically focuses on identifying earnings manipulation in financial statements for micro-level variables like accounting accruals, intangible assets, etc. This will help policy-makers and financial statement readers to be proactive while reading financial statements and taking any investment decision.
Challenges to energy transitioning in commercial buildings in the Nigerian built environment – from generator to RETs economy
Authors: Unuigbe Maria , Zulu Sambo Lyson , Johnston David
Published: August 2022

Purpose

Challenges to energy access in Nigeria have resulted in the widespread use of fossil fuel generating sets (generators) despite its renewable energy (RE) potential. Given the climate crisis, combined with the country's rapid population growth and expected rise in energy and building demand, transitioning to low-carbon electricity using REs like solar photovoltaic (PV) presents opportunities beyond securing its energy future. While PV use is growing in Nigeria, this is focused on the residential sector despite the identification of the commercial sector as a high energy consumer and a key platform for its integration. In line with this, this research aims to investigates the challenges to energy transitioning from generators to solar PV in commercial buildings.

Design/methodology/approach

A qualitative approach in line with grounded theory was adopted using in-depth face-to-face interviews with industry experts.

Findings

Two distinct but interrelated categories emerged: being held captive and being a saviour that represented a duality of systems, and/or processes formed the core category “Hostage Syndrome”. The core category (theory) was generated based on the explanations and expressions by participants about their concerns, interests, and the conditions under which they operate. The findings reveal the value attributed to generators beyond an operational role and the adjustments or mechanisms adopted by building professionals during their practice. It suggests a sphere of influence beyond the obvious financial and/or institutional aspects, as determining factors to what is viewed as sustainable which will be key to transitioning to REs.

Originality/value

This paper provides new and in-depth insight into understanding the conditions under which building professionals operate associated with their interpretations of “being sustainable”. The study highlights the need to consider psychological and cultural factors in the development of interventions, strategies and/or policies to support RE transition, particularly towards achieving a sustainable construction industry.