bluuebunny/crossref_metadata_2025 huggingface dataset:
NIR emitting BODIPY dyes for pH sensing
Authors: Kubheka Gugu , Molupe Nthabeleng , Mack John , Nyokong Tebello
Published: December 2022

The ease of functionalization of BODIPY dyes provides scope for preparing pH indicators by introducing suitable functional groups. In this work, two dimethylamino substituted BODIPY dyes 3 and 4 with styryl and phenylbuta-1,3-dienyl groups introduced at the 3,5-positions were synthesized, characterized, and studied for use as pH indicators. Incorporation of the electron-rich vinylene substituents yielded dyes that absorb in the NIR region with emission wavelengths of 796 and 797 nm for 3 and 4, respectively, in dimethylsulfoxide (DMSO). Time-dependent density functional theory (TD-DFT) calculations were performed to study the effect of adding an extra alkene bond in 4 on the photophysical properties. The extra alkene bond in 4 resulted in a 3 nm shift in the main NIR region absorption band, lower molar extinction coefficient values, higher emission wavelength, and a decrease in fluorescence quantum yield in all solvents studied. Upon protonation of the amino groups, a large blue shift is observed in both the absorption and emission wavelengths, along with an increase in the fluorescence quantum yields and longer fluorescence lifetimes. The [Formula: see text] values for 3 and 4 were estimated to be 2.9 (± 0.05) and 1.2 (± 0.05), respectively.
One-dimensional stacking array of 10,20-diphenyl-5,15-diazaporphyrin metal complexes
Authors: Mori Shiho , Sakurai Takahiro , Nishimura Tsubasa , Fukui Norihito , Miyake Yoshihiro , Shinokubo Hiroshi
Published: December 2022

We prepared a free-base 10,20-diphenyl-5,15-diazaporphyrin and its Ni(II), Cu(II), Pd(II), and Pt(II) complexes. These molecules uniformly form an infinite one-dimensional [Formula: see text]-stacking array in the solid state. The four-fold intermolecular hydrogen bonding interactions between the meso-nitrogen atom of the diazaporphyrin core and the ortho-hydrogen atom of the phenyl substituent dominate the crystal packing arrangement. The present study revealed that the meso-nitrogen atom of diazaporphyrins would be used as an inherent hydrogen bonding acceptor to construct supramolecular assemblies.
Demystifying Hidden Sensitive Operations in Android Apps
Authors: Sun Xiaoyu , Chen Xiao , Li Li , Cai Haipeng , Grundy John , Samhi Jordan , Bissyandé Tegawendé , Klein Jacques
Published: December 2022

Security of Android devices is now paramount, given their wide adoption among consumers. As researchers develop tools for statically or dynamically detecting suspicious apps, malware writers regularly update their attack mechanisms to hide malicious behavior implementation. This poses two problems to current research techniques: static analysis approaches, given their over-approximations, can report an overwhelming number of false alarms, while dynamic approaches will miss those behaviors that are hidden through evasion techniques. We propose in this work a static approach specifically targeted at highlighting hidden sensitive operations (HSOs), mainly sensitive data flows. The prototype version of HiSenDroid has been evaluated on a large-scale dataset of thousands of malware and goodware samples on which it successfully revealed anti-analysis code snippets aiming at evading detection by dynamic analysis. We further experimentally show that, with FlowDroid, some of the hidden sensitive behaviors would eventually lead to private data leaks. Those leaks would have been hard to spot either manually among the large number of false positives reported by the state-of-the-art static analyzers, or by dynamic tools. Overall, by putting the light on hidden sensitive operations, HiSenDroid helps security analysts in validating potentially sensitive data operations, which would be previously unnoticed.
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells
Authors: Qin Hua-Li , Bao Jing-Hui , Tang Jian-Jun , Xu Dan-Yan , Shen Li
Published: December 2022

Arterial remodeling is a common pathological basis of cardiovascular diseases such as atherosclerosis, vascular restenosis, hypertension, pulmonary hypertension, aortic dissection, and aneurysm. Vascular smooth muscle cells (VSMCs) are not only the main cellular components in the middle layer of the arterial wall but also the main cells involved in arterial remodeling. Dedifferentiated VSMCs lose their contractile properties and are converted to a synthetic, secretory, proliferative, and migratory phenotype, playing key roles in the pathogenesis of arterial remodeling. As mitochondria are the main site of biological oxidation and energy transformation in eukaryotic cells, mitochondrial numbers and function are very important in maintaining the metabolic processes in VSMCs. Mitochondrial dysfunction and oxidative stress are novel triggers of the phenotypic transformation of VSMCs, leading to the onset and development of arterial remodeling. Therefore, pharmacological measures that alleviate mitochondrial dysfunction reverse arterial remodeling by ameliorating VSMCs metabolic dysfunction and phenotypic transformation, providing new options for the treatment of cardiovascular diseases related to arterial remodeling. This review summarizes the relationship between mitochondrial dysfunction and cardiovascular diseases associated with arterial remodeling and then discusses the potential mechanism by which mitochondrial dysfunction participates in pathological arterial remodeling. Furthermore, maintaining or improving mitochondrial function may be a new intervention strategy to prevent the progression of arterial remodeling.
Characterization of Lipschitz Spaces via Commutators of Maximal Function on the p‐Adic Vector Space
Authors: He Qianjun , Li Xiang
Published: December 2022

In this paper, we give characterization of a p‐adic version of Lipschitz spaces in terms of the boundedness of commutators of maximal function in the context of the p‐adic version of Lebesgue spaces and Morrey spaces, where the symbols of the commutators belong to the Lipschitz spaces. A useful tool is a Lipschitz norm involving the John‐Nirenberg‐type inequality for homogeneous Lipschitz functions, which is new in the p‐adic field context.
Exploration of the Components and Pharmacological Mechanisms of Keyin Pill-Induced Liver Injury Based on Network Pharmacology
Authors: Xing Bo , Cui Yaling , Chen Ying , Lai Lingyun , Zhang Meiling , Xu Xiangbo , Wang Nan , Jiang Xiaowen , Xu Zihua , Zhao Qingchun
Published: December 2022

Background. Keyin pill (KP), a patented medicine in China, is used to treat psoriasis. However, KP has been reported to have liver toxicity, but its toxic substance basis and underlying mechanisms remain unclear. Therefore, this study aimed to explore the pharmacological mechanisms and components of KP-induced liver injury through animal experiments, UPLC-QTOF/MS combined with network pharmacology. Methods. Firstly, based on the immune stress mouse model, liver function parameters and hematoxylin-eosin (H&E) staining were detected to investigate KP-induced liver injury. The UPLC-QTOF/MS method was used to identify the components of KP. CTD database and literature mining were further applied to screen nonliver protective components. Subsequently, the nonliver protective components and their corresponding targets and targets of hepatotoxicity were analyzed by the method of network pharmacology. Finally, key targets from networked pharmacology were examined by the enzyme-linked immunosorbent assay (ELISA) and molecular docking. Results. Our results indicated that KP had hepatotoxicity in male Kunming mice, which could favor hepatocyte necrosis and infiltration of inflammatory cells. A total of 70 nonliver protective compounds were identified and screened. The results of network pharmacology illustrated that methoxsalen, obacunone, limonin, and dictamnine might be the main compounds that caused liver damage. The potential hepatotoxicity mechanisms of KP might be through the IL17 and apoptosis pathways to regulate IL6, TNFα, CASP3, and CASP8 targets, thereby causing inflammation, excessive release of factors, and hepatocyte necrosis. The results of the ELISA experiments indicated that KP could increase the release of IL6 and TNFα inflammatory factors in liver tissues. Molecular docking suggested that methoxsalen, obacunone, limonin, and dictamnine had moderate binding ability with CASP3 and CASP8. Conclusion. In this study, the material basis and potential pharmacological mechanisms of KP-induced liver injury were preliminarily explored. Our research provides the initial theoretical basis for reducing the toxicity of KP.
HMGA1 Aggravates Oxidative Stress Injury and Inflammatory Responses in IL-1β-Induced Primary Chondrocytes through the JMJD3/ZEB1 Axis
Authors: Ai Jianguo , Zhao Feng , Zhou Xiaowen
Published: December 2022

Introduction: Osteoarthritis (OA) is associated with oxidative stress injury (OSI) and inflammatory responses in chondrocytes. This study sought to explore the mechanism of high mobility group A1 (HMGA1) in interleukin-1beta (IL-1β)-induced OSI and inflammatory responses in primary chondrocytes. Methods: Primary chondrocytes were cultured and treated with IL-1β to establish an OA-cell model. Levels of HMGA1, Jumonji domain-containing 3 (JMJD3), and ZEB1 in cells were determined by real-time quantitative polymerase chain reaction and Western blot analysis. Cell viability, contents of tumor necrosis factor-α, IL-6, and IL-10, reactive oxygen species level, and glutathione peroxidase activity were assessed by the cell counting kit-8 assay, enzyme-linked immunosorbent assay, and assay kits. Enrichment levels of HMGA1 on the JMJD3 promoter and enrichment levels of JMJD3 and trimethylated histone H3 at lysine 27 (H3K27me3) on the ZEB1 promoter region were determined by chromatin immunoprecipitation. Functional rescue experiments were performed to analyze the impact of ZEB1 and JMJD3 on IL-1β-induced chondrocytes. Results: IL-1β treatment induced HMGA1 upregulation, OSI, and inflammatory responses in chondrocytes. HMGA1 downregulation reduced IL-1β-induced OSI and inflammatory responses in chondrocytes. Mechanically, HMGA1 was bound to the JMJD3 promoter to promote JMJD3 transcription, and JMJD3 induced demethylation of H3K27me3 on the ZEB1 promoter to promote ZEB1 transcription. Overexpression of JMJD3 or ZEB1 neutralized the protective role of silencing HMGA1 in IL-1β-induced chondrocytes. Conclusion: HMGA1 aggravated IL-1β-induced OSI and inflammatory responses in chondrocytes through the promotion of JMJD3 and ZEB1.
Ionizing Radiation-Induced DNA Damage Response in Primary Melanocytes and Keratinocytes of Human Skin
Authors: Meador Jarah A. , Morris Rebecca J. , Balajee Adayabalam S.
Published: December 2022

Currently, our knowledge of how different cell types in a tissue microenvironment respond to low and high linear energy transfer (LET) radiation is highly restricted. In this study, a comparative analysis was performed on γ-ray-induced DNA damage and repair in primary human melanocytes and keratinocytes isolated from 3 donors. Our study demonstrates a modest interindividual variability in both melanocytes and keratinocytes in terms of both spontaneous and ionizing radiation (IR)-induced 53BP1 foci formation and persistence. Melanocytes, in general, showed a slightly elevated (1.66–2.79 folds more) 53BP1 foci induction relative to keratinocytes after exposure to different doses of γ-rays (0.1–2.5 Gy) radiation. To verify the influence of ATM kinase on IR-induced 53BP1 foci formation, melanocytes and keratinocytes were treated with a specific ATM kinase inhibitor (KU55993, 10 μM) for 1 h prior to radiation. ATM kinase inhibition resulted in the reduction of both spontaneous and IR-induced 53BP1 foci by 17–42% in both melanocytes and keratinocytes of all the 3 donors. Increased persistence of IR-induced 53BP1 foci number was observed in ATM-inhibited melanocytes and keratinocytes after different post exposure times (6 h and 24 h). Taken together, our study suggests that interindividual variations exist in the induction and repair of DNA double-strand breaks (DSBs) in melanocytes and keratinocytes and that ATM is crucial for an optimal DSB repair efficiency in both human skin cell types.
Patterns of Surgical Recurrence in Patients with Hidradenitis Suppurativa
Authors: Cuenca-Barrales Carlos , Montero-Vílchez Trinidad , Sanchez-Diaz Manuel , Rodríguez-Pozo Juan-Ángel , Díaz-Calvillo Pablo , Martinez-Lopez Antonio , Arias-Santiago Salvador , Molina-Leyva Alejandro
Published: December 2022

Background: Surgery is an essential part of hidradenitis suppurativa (HS) treatment. Understanding and reducing surgical recurrence are crucial to obtaining the best results in patients’ treatment. Objective: The aim of the study was to characterize surgical recurrences in a cohort of patients with HS treated with wide excision and second-intention healing. Methods: A prospective nested case-control study was conducted. A cohort of patients with HS treated with wide excision and second-intention healing was monitored for 68 weeks. The surgical procedure was classified as case (recurrence) or control (no recurrence). The type of recurrence was classified according to the elementary lesion in tunnel or abscess and inflammatory nodule (AN) recurrence. Sociodemographic and clinical data likely related to recurrence and the type of recurrence were evaluated. Results: Sixty-three patients were included, receiving a total of 82 surgical procedures. The mean age of the patients was 36.18 years, and the surgical site presented a Hurley stage II severity in 79.26% (65/82) of the interventions. Tunnel recurrence was observed in 8.5% (7/82) and AN recurrence in 15.85% (13/82) of the interventions. Obesity was associated with a higher risk of recurrence, for both tunnel and AN recurrence. Hurley III at the surgical site, a history of pilonidal sinus, and higher International Hidradenitis Suppurativa Severity Score System (IHS4) after surgery and at week 68 increased the risk of tunnel recurrence. Conclusion: We propose classifying surgical recurrence based on the elemental type of lesion. Tunnel recurrence could originate in the depth of the surgical scar and could be associated with both surgical site factors and inflammatory load. AN recurrence could originate in the borders of the surgical scar and may particularly benefit from preoperative ultrasound.
Glucagon-Like Peptide-2 Ameliorates Age-Associated Bone Loss and Gut Barrier Dysfunction in Senescence-Accelerated Mouse Prone 6 Mice
Authors: Huang Yan-Mei , Xu Bing’er , Kuai Zheng , He Yu-Ting , Lu Yi , Shen Ji-Ping , Wu Ke-Fen , Wu Jia-Yu , Ren Wei-Ying , Hu Yu
Published: December 2022

Introduction: Senile osteoporosis is one of the most common age-related diseases worldwide. Glucagon like peptide-2 (GLP-2), a naturally occurring gastrointestinal peptide, possesses therapeutic effects on bone loss in postmenopausal women and ovariectomized rats. However, the role of GLP-2 in senile osteoporosis and underlying mechanisms has not been explored. Methods: GLP-2 was subcutaneously injected into the 6-month-old male senile osteoporosis model of senescence-accelerated mouse prone 6 (SAMP6) mice for 6 weeks. SAMP6 subjected to normal saline and senescence-accelerated mouse resistant 1 served as control groups. Micro-computed tomography was performed to evaluate the bone mass and microarchitecture of the mice. Osteoblastic and osteoclastic activities were determined by biochemical, quantitative real-time PCR, histological, and histomorphometric analyses combined with hematoxylin-eosin, toluidine blue, and tartrate-resistant acid phosphatase staining. We also examined the proteins and structure of intestinal tight junction using immunohistochemical assay as well as a transmission electron microscope. Serum inflammation marker levels were measured using ELISA. Additionally, anti-oxidative enzymes GPX-4 and SOD-2 and receptors of GLP-2 and vitamin D expression in the ileum and colon were detected under immunofluorescence staining. Results: Six-week GLP-2 treatment attenuated bone loss in SAMP6 mice, as evidenced by increased bone mineral density, improved microarchitecture in femora, and enhanced osteogenic activities. In contrast, the activity of osteoclastic activity was not obviously inhibited. Moreover, GLP-2 ameliorated tight junction structure and protein expression in the intestinal barrier, which was accompanied by the reduction of TNF-α level. The expression of receptors of intestinal GLP-2 and vitamin D in the ileum was elevated. Furthermore, the oxidative stress in the intestines was improved by increasing the GPX-4 and SOD-2 signaling. Conclusion: Our findings suggest that GLP-2 could ameliorate age-associated bone loss, tight junction structure, and improved antioxidant enzyme activity in the gut in SAMP6 mice. Amelioration of gut barrier dysfunction may potentially contribute to improving bone formation and provide evidence for targeting the entero-bone axis in the treatment of senile osteoporosis.
Dose-Response Relationship between Red Blood Cell Distribution Width and In-Hospital Mortality in Oldest Old Patients with Acute Ischemic Stroke
Authors: Li Mingquan , Wang Liumin , Zhu Xinmei , Huang Jian , Zhang Yanli , Gao Bei , Liu Xiaoyun , Yin Jingjing , Wei Pingmin
Published: December 2022

Introduction: It is crucial to identify predictors of mortality in the early stage of acute ischemic stroke for the oldest old (aged ≥80 years) because of their poor overall survival outcomes. However, limited data are available as the oldest old have often been excluded from previous clinical studies. Hence, we aimed to assess the predictive effect of red blood cell distribution width on in-hospital mortality and the dose-response relationship between the red blood cell distribution width and in-hospital mortality in oldest old with acute ischemic stroke. Methods: A retrospective cohort study was performed in two tertiary hospitals. Patients aged ≥80 years admitted due to acute ischemic stroke from January 1, 2014, to January 31, 2020, were included in the study. We divided the eligible patients into 3 groups with tertiles of red blood cell distribution width. Restrictive cubic spline and robust locally weighted regression analysis were performed to test the dose-response relationship between red blood cell distribution width and the in-hospital mortality risk. All-cause in-hospital mortality was the main study outcome. Results: Overall, 606 patients were included in the final analysis. Red blood cell distribution width was categorized into 3 groups (T1: <13.7%, T2: 13.8–15.7%, and T3: >15.7%). The rationality of this categorization was then validated with restricted cubic spline and robust locally regression smoothing scatterplot, respectively. After adjusting for demographic and clinical features, a higher red blood cell distribution width was independently associated with in-hospital mortality and the hazard ratio (HR) was 3.31 (95% CI 2.47–4.45, p < 0.001). There was a positive dose-response relationship between red blood cell distribution width and mortality risk. Sensitivity analysis identified no conspicuous change in the HR. Conclusions: Red blood cell distribution width may be a valuable and simple measure for predicting in-hospital mortality in oldest old patients with acute ischemic stroke.
Association of Dietary Patterns with Parkinson’s Disease: A Cross-Sectional Study Based on the United States National Health and Nutritional Examination Survey Database
Authors: Xu Shulan , Li Wei , Di Qing
Published: December 2022

Introduction: Although studies have explored some dietary patterns for Parkinson’s disease (PD), more other dietary patterns and food item under the dietary pattern are needed to investigate. This study aimed to identify more categories of dietary patterns for PD and further explore the association of single food item with PD. Methods: The 2015–2018 US National Health and Nutritional Examination Survey (NHANES) database was used for data extraction. The data on demographics and nutrient intake were collected. Dietary patterns were derived from food categories by factor analysis. The association between dietary patterns or single food item and PD was explored using logistic regression analysis in the overall and only in secure PD cases, and results were expressed as odds ratio (OR) with 95% confidence intervals (CIs). Sensitivity analysis was performed by excluding participants using unsecure PD medication. Results: Among 5,824 participants aged over 50 years, 91 were diagnosed as PD. Factor analysis identified 5 major dietary pattern factors. We observed that the increased adherence to Mediterranean diet (MeDi) was associated with the reduced odds of PD (OR = 0.78, 95% CI: 0.65–0.93). The higher adherence to Western pattern was associated with the increased odds of PD (OR = 2.19, 95% CI: 1.16–4.14). In addition, high intake of sweets under Western pattern was found to be associated with the higher odds of PD (OR = 2.01, 95% CI: 1.08–3.71). Conclusions: The odds of PD decreased by higher MeDi adherence and increased by higher Western pattern adherence, especially sweets intake in this pattern, suggesting population ≥50 years should adhere to MeDi pattern and decrease the adherence to Western pattern, reducing the intake of sweets.
Laparoscopic Management of Rudimentary Uterine Horns in Patients with Unicornuate Uterus: A Systematic Review
Authors: Abboud Krystle , Giannini Andrea , D’Oria Ottavia , Ramadan Aya , Ayed Amal , Laganà Antonio Simone , Chiantera Vito , Sleiman Zaki
Published: December 2022

Introduction: Unicornuate uterus is a rare Müllerian anomaly. Its potential association with a rudimentary uterine horn can cause a diagnostic delay. The most common consequences are pelvic pain, hematometra, and endometriosis. Diagnosis of a unicornuate uterus is usually done by imaging combining ultrasound and magnetic resonance imaging. The aim of this systematic review is to assess the role of laparoscopic approach in the management of this rare condition. Methods: A comprehensive search was performed in PubMed, EMBASE, SCOPUS, and Web of Science databases prior to 1 May 2022 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA). The inclusion criteria were: cases of rudimentary horn managed through laparoscopy only; laparoscopic treatment of communicating or noncommunicating uterine horn. Results: The search strategy identified 45 articles. After this first screening, 37 studies were evaluated. The full text of remaining articles was examined. 35 studies were finally included in this article. All included studies were case reports, due to the rarity of this condition. Rudimentary horns were noncommunicating in all cases. Conclusion: The laparoscopic removal of a rudimentary uterine horn could be considered a feasible therapeutic option. An accurate preoperative evaluation is mandatory to assess anatomic variants and to select the optimal and tailored surgical approach, based also on the symptoms complained by the patient.
Development Digitization In Enhancement Potency Tour Village Through Smart Village Concept in the Village Permis and Rajik South Bangka Regency
Authors: Julia Julia , Imainul Aprilian Rahil , Yanto Yanto
Published: December 2022

Tourism is a sector that has the potential to be developed as a source of regional income, because in addition to providing benefits for the tourist attractions themselves, it also provides benefits to the supporting infrastructure, such as restaurants, lodging places, industrial centers, souvenir centers, etc.

Digitization of tourism is one of the important strategies in responding to the digital-oriented civilization of society in meeting their needs for traveling. Digitization of tourism is considered the right step in promoting tourism through a digital approach that has an impact on the development of tourism potential in a tourist village.

Based on the results of field observations, various problems were found in Permis and Rajik Villages, South Bangka Regency, namely the lack of efforts to publicize tourism potential in Permis and Rajik villages. Lack of knowledge of the village government regarding website creation.
Assessment of the Readiness of Teachers for Developing Students’ Skills in Speaking English through the Use of the “Zoom” Platform
Authors: Maming Jimmy Bernabe , Maravilla Wes Harven G.
Published: December 2022

Online learning platforms such as “Zoom” platform enable teachers who want to teach a second language like English without having to leave home, especially during the height of the (COVID-19) pandemic in the Kingdom of Thailand. The researcher investigated the readiness of English teachers for the employment of skills needed for online classes. The mixed method (quantitative and qualitative) research strategy was adopted in this study with the questionnaire as the main tool supported by interviews and observation. The data gathered researcher utilized the following statistical tools/formula: frequency, mean distribution, standard deviation, coefficient of variation, and t-test. 1. Thirty-one (31) to 40 years old have the greatest number of respondents; 48 out of the 90 or 53.3% of the respondents are female and 42 out of the 90 or 46.7% of the respondents are male, and most of the respondents are teaching Primary 1 and 2. conducting small-group projects in an online class is the most experienced challenge encountered by the teachers in teaching the English Language through the “Zoom” platform. The study's findings are considered helpful in increasing institutional support for faculty development plans that will help faculty members transition from traditional methods to virtual ones.
Precarity and State Liberal Approach toward Indonesian Local Game Industry
Authors: Allifiansyah Sandy , Nedpogaeo Asawin
Published: December 2022

This paper aims to portrait the contemporary situation of Indonesian local game industry regarding the working-class issues and state approach to the development and sustainability. As Indonesian local game industry began a new era after state recognition in 2014, the industrial durability in the national creative sector is often questioned. A case study method is applied to response and diagnose one of the newest creative economic sectors in Indonesia. Interviewing various parties such as two related state ministries, twelve founders of local game studios, ten local game workers, and representative of labor union. The result exposes a liberal approach from the state in nurturing local game industry such as free-market competition, nescience, and quasi-patronage. This particular style of state’s cultural policy to local gaming industry has resulted in precarious situation among local game labors as the state’s instruments in contemporary creative industry.
Analysis of Risk Management Implementation in the Internal Audit Unit (SPI) Politeknik Pelayaran Surabaya Using Iso 31000:2018
Authors: Masita Ita , Yuhertiana Indrawati
Published: December 2022

The application of risk management aims to minimize the probability and or consequences of unfavorable events as well as increase awareness of risk in strategic and operational decision making in an effort to achieve organizational goals. The Internal Audit Unit (SPI) Politeknik Pelayaran Surabaya is a supervisory unit formed to assist the implementation of Good University Governance by carrying out inspections or audits of all work units in the non-academic field.Risk treatment is required through risk management as the implementation of the management function in risk management at SPI Politeknik Pelayaran Surabaya. The risk management process uses a standard risk management process 31000 which consists of a context setting process, risk identification, risk analysis, risk evaluation, risk management, monitoring and review, and communication and consultation. This study uses a descriptive qualitative method with a case study at Internal Audit Unit (SPI) Politeknik Pelayaran Surabaya which describes and analyzes risk management using interview and documentation techniques in data collection. Data were analyzed using an interactive model, including data collection, data reduction, data presentation, and conclusions or verification. The final result of the risk management analysis of the internal audit unit (SPI) Politeknik Pelayaran Surabaya is a form of handling strategy in the implementation of internal control.
Teaching Amidst the Pandemic: Exploring the Perceptions and Experiences of Teachers in Remote Rural Municipalities in the Philippines
Authors: Legarde Michael Angelo A. , Sumandal Arman H.
Published: December 2022

The world has been shaken by the advent of the COVID-19 pandemic, which has resulted in a dramatic loss of human life and poses an unprecedented challenge to almost all aspects of life, and the Philippines has not been an exception to these challenges. As a result, this deadly situation has flipped the offline teaching process and paved the way towards online-based teaching. This study was conducted to determine the perceptions and experiences of teachers in the remote areas towards online teaching.   This study employed a cross-sectional explanatory research design and the analyses reveal that respondents with "high" technological proficiency are more likely to have a "positive" attitude toward online education whereas respondents with "poor" technological skills are more likely to have a "negative" attitude toward online learning. This strongly suggest that educational leaders may venture on training teachers on how to develop their technological knowledge and skills since it has a significant impact to their attitude towards online teaching. Moreover, further analysis also reveals that the relationship between teacher-respondents’ perceptions towards online teaching and their technological knowledge and skills was statistically significant. It is also recommended that training in online teaching needs to be provided to teachers to widen their understanding of online teaching.
Contextualized and Localized Supplementary E-Learning Materials in Science 8 Physics
Authors: Agbunag Maylene Ramirez
Published: December 2022

This study is in response to the current situation in the Philippines that aims to support students' learning needs even from the comfort of their own homes, as well as to improve the teaching and learning process through the use of contextualized and localized supplementary e-learning materials for students. This study aimed to develop, evaluate, and determine the effectiveness of contextualized and localized supplementary e-learning materials for Grade 8 students in Science (Physics) at a public national high school in Antipolo City during the school year 2021-2022. The study utilized both descriptive and experimental research designs. The developed materials were evaluated by twenty science experts and twenty science teachers from the City Schools Division of Antipolo. The participants of the study were thirty Grade 8 students. The data gathering instruments used in this study were the questionnaire checklist, pretest, and posttest. The study showed that the developed contextualized and localized supplementary e-learning materials in science 8 (Physics) helped in the improvement of the teaching and learning process. It is recommended that the materials be used accordingly and constantly modified for improvement.
Enhancement of the Performance of Junior High School Students using Numeracy Mobile Game on Operations of Integers
Authors: Lopez Lydia Marie R.
Published: December 2022

This study aimed to evaluate and validate the developed numeracy mobile game to help improve the performance of junior high school students on the operations of integers in a public national high school in Antipolo City, the Philippines.  The researcher used experimental and descriptive research designs in the study.  The sources of data in this research were eighty (80) JHS students, twenty (20) from each grade level, from Old Boso-Boso National High School. Other respondents were the forty (40) teacher respondents consisting of twenty (20) experts and twenty (20) math teachers from Schools Division of Antipolo. The statistical tools used in this study were the frequency, percentage, weighted mean, independent-samples t-test, and paired t-test.  It was revealed that there was no significant difference between the evaluations of the two groups of respondents on the developed numeracy mobile game in operations of integers in terms of game mechanics, visual aesthetic design, narrative design, incentive system, musical scores, and content and skills. It is recommended that the user interface of the game needs some enhancements like the controls for arrows up and down and improve the tutorial part before starting the real game or at the start of every level.
A fantasia decorativa da modernidade dos incultos, malcriados e desviados
Authors: Malta Marize
Published: December 2022

A arte decorativa, com seu pressuposto de criar coisas de fantasia ornamental, costumou estar alijada dos debates sobre modernismos no Brasil, apesar de sua ação significativa para os processos de modernidade. Diante de sua natureza polissêmica, muitas manifestações de cunho popular podem estar nela incluídas, produzidas por atores ausentes da historiografia da arte canônica, considerados incultos, malcriados e desviados. Ao assumir carros alegóricos e fantasias de Carnaval como atitudes decorativas, referenciadas por Fléxa Ribeiro, é possível desenvolver outras visadas sobre ações decorativas da modernidade e sobre seus protagonistas, por vezes pouco conhecidos nessas ações e, na maioria, anônimos.
Como acabou o neoconcretismo?
Authors: Brown Nicholas
Published: December 2022

Neste artigo, Nicholas Brown analisa a trajetória de Hélio Oiticica desde seus trabalhos da década de 1950, alinhados às pesquisas da vanguarda neoconcreta, até sua obra dos anos 1970, demonstrando como o componente da experiência, tematizado na produção tardia de Oiticica, encontra-se implícito à objetividade do seu trabalho inicial, numa espécie de mobilização permanente da dialética entre ideia e o suporte literal existente no espaço. Examina, ainda, a configuração específica que a correlação entre história política e cadeia histórico-artística adquire no Neoconcretismo. Finalmente, a partir da contradição produtiva entre substrato concreto e superfície significante na obra de Oiticica, Brown sinaliza como a dinâmica entre história intelectual e sociopolítica se apresenta ao final da trajetória do artista como reivestimento do objeto de arte a contrapelo da lógica da mercadoria.
Comunicação e Educação para o Desenvolvimento Sustentável: a articulação entre a graduação na Unesp e a Agenda 2030
Authors: Pinhabe Isadora Sonego , Cabral Raquel , Galvão Thiago Gehre
Published: December 2022

Este artigo tem como objetivo discutir criticamente os resultados de uma pesquisa que investigou o alinhamento do ensino superior com a Agenda 2030, por meio da análise de planos de ensino dos cursos de graduação da Universidade Estadual Paulista vigentes em 2019 e de questionário com docentes. Como resultados, identifica-se que princípios da Educação para o Desenvolvimento Sustentável e comunicação podem ser desenvolvidos para potencializar processos em curso de articulação pedagógica e institucional com os Objetivos de Desenvolvimento Sustentável.
Comunicação para a Paz em Múltiplas Dimensões: reflexões sobre cenários desafiadores, para uma sociedade mais justa e igualitária.
Authors: Dias Neto João de Deus
Published: December 2022

RESENHA DE LIVRO:
Título: Comunicação para a Paz em Múltiplas Dimensões: reflexões sobre cenários desafiadores, para uma sociedade mais justa e igualitária.

Larissa Pelúcio e Raquel Cabral (orgs.)
Comunicação, contradições narrativas e desinformação em contextos contemporâneos
Cultura Acadêmica
São Paulo, 2021
228 páginas.
Disponível online: https://www.culturaacademica.com.br/catalogo/comunicacao-contradicoes-narrativas-e-desinformacao/
Clinical Utility of Short-Term Blood Pressure Measures to Inform Long-Term Blood Pressure Management
Authors: Wang Nelson , Harris Katie , Woodward Mark , Harrap Stephen , Mancia Giuseppe , Poulter Neil , Chalmers John , Rodgers Anthony ,   on behalf of the PROGRESS and ADVANCE collaborators
Published: December 2022

Background:

Decisions about hypertension management are substantially influenced by blood pressure (BP) levels measured before and soon after starting BP lowering drugs. We aimed to assess the utility of short-term BP changes in individuals in terms of long-term treatment response.

Methods:

Post hoc analyses of 2 randomized trials with 4-to-6 weeks active run-in for all participants, followed by randomization to active BP lowering treatment (combination perindopril±indapamide) or placebo. We categorized individuals by degree of systolic BP (SBP) change during active run-in treatment and assessed associations with subsequent postrandomization placebo-corrected BP reduction, cardiovascular events, and tolerability. We included individuals with baseline BP ≥140/90 mm Hg from the PROGRESS trial (Perindopril Protection Against Recurrent Stroke Study; 4275 individuals with cerebrovascular disease) and ADVANCE trial (The Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation; 6610 individuals with diabetes).

Results:

During the active run-in period, the proportion of participants with initial SBP changes in 4 categories (SBP increase, 0–9.9 mm Hg decrease, 10–19.9 mm Hg decrease, and ≥20 mm Hg decrease) were 17%, 27%, 28%, and 28% in PROGRESS and 21%, 22%, 24%, and 33% in ADVANCE. Randomization to active therapy achieved similar placebo-corrected long-term BP reductions across the 4 initial SBP change groups in both trials (
P
-values for heterogeneity >0.1). There was no significant difference in achieving BP <140/90 mm Hg at follow-up, major cardiovascular events, nor treatment tolerability according to the SBP change during active run-in period (all
P
-values >0.1).

Conclusions:

An individual’s apparent BP change immediately after commencing therapy has limited clinical utility. Therefore, more emphasis should be given to use of evidence-based regimens and measures over the long-term to ensure sustained BP control.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00145925.
Wind-Forced Seasonal Exchange between Marginal Seas and the Open Ocean
Authors: Spall Michael A.
Published: December 2022

The circulation within marginal seas subject to periodic winds, and their exchange with the open ocean, are explored using idealized numerical models and theory. This is motivated by the strong seasonal cycle in winds over the Nordic Seas and the exchange with the subpolar North Atlantic Ocean through the Denmark Strait and Faroe Bank Channel. Two distinct regimes are identified: an interior with closed f/h contours and a shallow shelf region that connects to the open ocean. The interior develops a strong oscillating along-topography circulation with weaker ageostrophic radial flows. The relative importance of the bottom Ekman layer and interior ageostrophic flows depends only on ωh/Cd, where ω is the forcing frequency, h is the bottom depth, and Cd is a linear bottom drag coefficient. The dynamics on the shelf are controlled by the frictional decay of coastal waves over an along-shelf scale Ly = f0LsHs/Cd, where f0 is the Coriolis parameter, and Ls and Hs are the shelf width and depth. For Ly much less than the perimeter of the basin, the surface Ekman transport is provided primarily by overturning within the marginal sea and there is little exchange with the open ocean. For Ly on the order of the basin perimeter or larger, most of the Ekman transport is provided from outside the marginal sea with an opposite exchange through the deep part of the strait. This demonstrates a direct connection between the dynamics of coastal waves on the shelf and the exchange of deep waters through the strait, some of which is derived from below sill depth.

Significance Statement

The purpose of this study is to understand how winds over marginal seas, which are semienclosed bodies of water around the perimeter of ocean basins, can force an exchange of water, heat, salt, and other tracers through narrow straits between the marginal sea and the open ocean. Understanding this exchange is important because marginal seas are often regions of net heat, freshwater, and carbon exchange with the atmosphere. The present results identify a direct connection between processes along the coast of the marginal sea and the flow of waters through deep straits into the open ocean.
Book review: Anil Kumar Vaddiraju, Urban Governance and Local Democracy in South India
Authors: Kenoth Rajesh
Published: December 2022

Anil Kumar Vaddiraju, Urban Governance and Local Democracy in South India. Routledge, 2021, 112 pp., ₹695. ISBN: 9781032045795 (Paperback).
Career transitions from the English Premier League: Cooling out the mark with possible selves
Authors: Hickey Colm , Roderick Martin
Published: December 2022

Achieving and then maintaining a career as a professional athlete is hard. Saturated labour markets and the ever-present risk of deselection or injury means that career transitions are an inevitable feature of all athletes’ biographies. Like many other professional sports organisations, English Premier League (EPL) clubs have been called upon to provide adequate support to players upon their release from their club. This investigation will examine the experiences and attitudes of EPL players during their career transitions and contextualise the support that EPL club Education and Welfare Officers (EWOs) offer players during this process. Vignette interviewing was employed to engage a purposive sample, consisting of ten EPL players and five EWOs. A combination of Goffman's cooling-out metaphor and notions of Possible Selves is used to unpack the experiences of both players and EWOs. This study offers the proposition that players are Cooled Out as part of their career transitions by EWOs encouraging players to engage with Possible Selves both in and away from footballing environments. Such a process contributes to the empowerment of individuals to manage and successfully navigate their career transition from one club to another or away from the professional game entirely.
Siltuximab as a primary treatment for cytokine release syndrome in a patient receiving a bispecific antibody in a clinical trial setting
Authors: Lipe Brea C , Renaud Thomas
Published: December 2022

Introduction

Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are common toxicities associated with immunotherapies, including T cell redirecting bispecific antibodies. Although cooperative group guidelines recommend the use of tocilizumab or other IL-6/IL-6R inhibitors for the management of CRS and ICANS, reports on the use of siltuximab, an IL-6 inhibitor, for the treatment of CRS are limited.

Case report

We present the case of a 77-year-old male who received T cell redirecting bispecific antibody therapy with talquetamab for relapsed/refractory multiple myeloma (RRMM) and developed CRS with concurrent ICANS after receiving a second dose of talquetamab.

Management and Outcome

The patient received an infusion of siltuximab. The patient recovered from CRS within 1 h of siltuximab administration and ICANS within 7 h of siltuximab administration. Patient tolerated the subsequent dose of talquetamab with no evidence of CRS and continued on study.

Discussion

This case describes the successful use of siltuximab for the management of CRS in a patient treated with a T cell redirecting bispecific antibody for RRMM.
The Civic Value of Education: How Scholastic Experiences Create Active Citizens
Authors: Stoddard Samuel V.
Published: December 2022

Political scientists have long recognized educational attainment as a strong predictor of voter turnout, but the mechanisms through which educational experiences lead voters to the polls remain underexplored. This research begins to open this proverbial black box to understand the specific types of scholastic experiences that encourage voting. Grounded in previous findings by scholars of policy feedback and political socialization, a mix of qualitative and quantitative data analyses reveal that nonacademic high school experiences can have powerful and lasting interpretive effects. Participants in performance and service-based extracurricular activities are consistently recognized for their efforts and connected to their communities, leading to interpretations of dignity, efficacy, and civic duty. As a result, these young Americans are more likely than their peers to vote in early adulthood. Further analyses uncover critical effects based on socioeconomic status: many interpretive educational experiences have more profound impacts on the voting behaviors of young citizens who may lack opportunities for positive political socialization in their home and social environments. Unfortunately, those young Americans whose participatory behaviors could be most impacted by uplifting extracurricular experiences are also least likely to have access to and participate in these programs, a gap that may have been exacerbated during the recent pandemic.
Comparing Intramedullary Nails Versus Dynamic Hip Screws in the Treatment of Intertrochanteric Hip Fractures on Post-operative Rehabilitation Outcomes:A Systematic Review Protocol
Authors: Papp Steve , Backman Chantal , Konikoff Lauren , Tanuseputro Peter , Harley Anne , Shah Soha , Berdusco Randa , Domecq Marie-Cécile , Poitras Stéphane , French-Merkley Veronique , Beaulé Paul E.
Published: December 2022

Background: Intertrochanteric hip fractures are treated by fixation with either an intramedullary (IM) Nail or Dynamic Hip Screw (DHS). It is unknown whether one surgery type has better post-operative rehabilitative outcomes for the hip fracture population. This systematic review aims to compare post-operative rehabilitation outcomes of intertrochanteric hip fractures treated via IM Nails versus DHS. Methods: We will conduct a systematic review following the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) format. A search strategy will be developed, and the following databases will be searched: MEDLINE, EMBASE, Cochrane Library, and Web of Science. Two reviewers will perform a two-step screening process and data extraction of included studies. Any disagreement will be resolved with a discussion or a third reviewer. Risk of bias and the quality of the studies will also be assessed. A narrative synthesis will be used for the data analysis. Conclusion: This systematic review will provide evidence for orthopaedic surgeons and rehabilitation clinicians to further improve patient rehabilitation outcomes post-hip fracture surgery.