bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of an E2F Target‐Related Gene Signature to Improve the Prognosis Prediction for Patients with Hepatocellular Carcinoma
Authors: Bian Jing , Chen Xi , Jiang Mingyan , Gao Xinghua
Published: July 2021

Liver cancer is one of the most common malignant tumors in the world, of which hepatocellular carcinoma (HCC) is the most common histological subtype. Although thousands of biomarkers related to HCC survival and prognosis have been found through database mining, the predictive effects of single-gene biomarkers are not specific enough. Therefore, we aimed to construct a pathway-related signature that could effectively forecast HCC prognosis. We obtained gene expression data and clinical patient information from The Cancer Genome Atlas database (TCGA). Univariate and multivariate Cox regression analyses were used to identify genes enriched in the E2F target gene pathway by Gene Set Enrichment Analysis. In the training set, NBN, PHF5A, CDCA8, AK2, and EXOSC8 were significantly associated with overall survival. They were validated in the test and entire groups, confirmed by Gene Expression Omnibus (GEO), and compared with two known prognostic signatures for HCC. Overall, we demonstrated a novel five-mRNA prognostic signature based on E2F targets that successfully predicted the survival of HCC patients, is independent of clinicopathological data, and displayed superior prediction performance in HCC prognosis. Our study elucidates the cell cycle mechanism in identifying patients with poor HCC prognosis. The application of our five-mRNA prognostic signature may improve risk stratification in HCC patients and existing methods for survival prediction.
The Angle of the Microguidwire on the Lateral Projection: a Prediction of Cannulation of the Occluded Inferior Petrosal Sinuses for the Transvenous Embolization of Cavernous Sinus Dural Arteriovenous Fistulas
Authors: Lv Xianli
Published: July 2021

OBJECTIVE: To describe that the angle of the guidwire on lateral projection under fluoroscopic image is a prediction of cannulation of the occluded inferior petrosal sinus in the transvenous embolization of cavernous sinus dural fistulas.METHODS: From January 2018 through January 2021, 12 consecutive cavernous sinus dural fistulas with ipsilateral inferior petrosal sinus occlusion identified in 12 patients were cured by cannulation of the occluded ipsilateral inferior petrosal sinus. Clinical, radiologic and procedure data of the 12 patients were retrospectively reviewed. The angle of microguidewire between on lateral projection under fluoroscopic image between the inferior petrosal sinus and the internal jugular vein was measured by 180°Protractor(Deli Group Co., LTD, Zhejiang, China). RESULTS: In the 12 patients, access via the occluded ipsilateral inferior petrosal sinus was primarily attempted as the transvenous approach. During the procedure, the angle of microguidwire on lateral projection under fluoroscopic image between the inferior petrosal sinus and the internal jugular vein was 117°±7°, which is very useful to confirm the cannulation of the occluded inferior petrosal sinus. Complete occlusion was achieved in all fistulas, with no procedure-related morbidity or mortality. Postprocedural symptom was improved in all patients. CONCLUSION: Cannulation of an occluded inferior petrosal sinus is possible and reasonable as an initial access attempt for cavernous sinus dural fistulas. The angle of microguidwire on the lateral projection under fluoroscopic image can help to confirm the orifice of the occluded inferior petrosal sinus.
CD10 and Das1: A Biomarker Study Using Immunohistochemistry to Subtype Gastric Intestinal Metaplasia
Authors: Koulis Athanasios , Costanzo Natasha , Mitchell Catherine , Lade Stephen , Goode David , Busuttil Rita A , Boussioutas Alex
Published: July 2021

Background: Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into the complete and incomplete subtypes, the latter being associated with a greater risk of progression. However, the clinical utility of IM subtyping remains unclear, partially due to the absence of reliable defining biomarkers.Methods: Based on gene expression data and existing literature, we selected CD10 and Das1 as candidate biomarkers to distinguish complete and incomplete IM glands in tissues from patients without GC (IM-GC) and patients with GC (IM+GC). Immunohistochemical staining of individually subtyped IM glands was scored after blinding by two researchers using tissue belonging to both IM-GC and IM+GC patients. Whole tissue Das1 staining was further assessed using digital image quantification (cellSens Dimension, Olympus).Results: Across both cohorts CD10 stained the IM brush border and was shown to have a high sensitivity (87.5% and 94.9% in IM-GC and IM+GC patients respectively) and specificity (100.0% and 96.7% respectively) with an overall AUROC of 0.944 for complete IM glands. By contrast Das1 stained mainly goblet cells and the apical membrane of epithelial cells, mostly of incomplete IM glands with a low sensitivity (28.6% and 29.3% in IM-GC and IM+GC patients respectively) but high specificity (98.3% and 85.1% respectively) and an overall AUROC of 0.603 for incomplete IM glands. A combined logistic regression model showed a significant increase in AUROC for detecting complete IM glands (0.955 vs 0.970). Whole tissue digital quantification of Das1 staining showed a significant association with incomplete IM compared to complete IM, both in IM-GC and in IM+GC patients (p=0.016 and p=0.009 respectively, Mann-Whitney test and unpaired t test used). Additionally, complete IM in IM+GC patients exhibited significantly more Das1 staining than in IM-GC patients (p=0.019, Mann-Whitney test). Conclusions: These findings suggest that CD10 is an outstanding biomarker for complete IM and Das1 may be useful as a secondary biomarker for IM glands at greater risk of progression irrespective of IM subtype. Overall, the clinical use of these biomarkers could lead to improved patient stratification and targeted surveillance.
Microvascular Injury With Secondary Edema, Bronchoconstriction and Vasoconstriction of Non-involved Lung Parenchymal Segments May Contribute to Clinical Deterioration of Non-critically Ill Patients Hospitalized for SARS-CoV-2 Pneumonia Without Evidence of Pulmonary Embolism: A Preliminary Study.
Authors: MAINCENT Cécile , PERRIN Christophe , CHIRONI Gilles , Baqué-Juston Marie , Berthier Frédéric , Paulmier Benoit , Hugonnet Florent , Dittlot Claire , Farhad Ryan Lukas , Renvoise Julien , Serrano Benjamin , Nataf Valérie , Mocquot François , Keita-Perse Olivia , Claessens Yann-Erick , Faraggi Marc
Published: July 2021

Purpose: We aimed to better understand the pathophysiology of SARS-CoV-2 pneumonia in non-critically ill hospitalized patients secondarily presenting with clinical deterioration and increase in oxygen requirement.Methods: We consecutively enrolled patients without clinical or biological evidence for superinfection, without left ventricular (LV) dysfunction and for whom a pulmonary embolism was discarded by computed tomography pulmonary angiography. We investigated lung ventilation and perfusion (LVP) by LVP scintigraphy, and, 24 hours later, left and right ventricular function by 99mTc-labelled albumin gated-blood-pool scintigraphy with late (60 mn) tomographic albumin images on the lungs to evaluate lung albumin retention that could indicate microvascular injuries with secondary edema. Results: We included 13 patients with confirmed SARS-CoV-2 pneumonia. All had CT evidence of organizing pneumonia and normal LV ejection fraction.No patient demonstrated preserved ventilation with perfusion defect (mismatch), which may eliminate a distal lung thrombosis. Patterns of ventilation and perfusion were heterogeneous with sometimes healthy lung segments paradoxically hypoperfused and hypoventilated while both normal perfusion and ventilation were maintained in segments with organizing pneumonia (n=4). Lung albumin retention in area of organizing pneumonia was observed in 9 patients, indicating microvascular injuries, vessel permeability increase and secondary edema.Conclusion: In hospitalized non-critically ill patients without pulmonary embolism or LV dysfunction, various types of damage may contribute to clinical deterioration including microvascular injuries and secondary edema, broncho and vasoconstriction of area not involved by organizing pneumonia while no evidence was found for significant distal thrombosis detectable by LVP scintigraphy.
Event-triggered Synchronization of Uncertain Delayed Generalized RDNNs
Authors: Zhang Weiyuan , Li Junmin , Xing Keyi , Zhang Rui , Zhang Xinyu
Published: July 2021

This paper investigates the exponential synchronization analysis of master–slave chaotic uncertain delayed generalized reaction-diffusion neural networks (GRDNNs) with event-triggered control scheme. A delay GRDNNs system model for the analysis is constructed by investigating the effect of the network transmission delay. By constructing a novel Lyapunov–Krasovskii functional and using a delay system approach for designing event-triggered controllers and some inequality techniques like Jensen’s inequality, Wirtinger’s inequality and Halanay’s inequality, the criteria are obtained for the event-triggered synchronization analysis and control synthesis of delayed GRDNNs. The synchronization criteria are formulated in terms of linear matrix inequalities. Finally, we conclude that the slave systems synchronize with the master systems. Two examples show the proposed theoretical results are feasible and effective.
Immunity to SARS-CoV-2 in a Dialyzed Patient Who Developed COVID-19 Twenty Days After the Second Dose of BNT162b2 Vaccine: a Case Report
Authors: MANNI Sabrina , LOTTE Laurène , BAL Antonin , JOSSET Laurence , LINA Bruno , TRABAUD Mary-Anne , DESTRAS Gregory , POZZETTO Bruno , VALETTE Martine , PASSERON Corinne , SEITZ-POSLKI Barbara , SINDT Audrey , VASSALLO Matteo
Published: July 2021

IntroductionEnd stage kidney disease (ESKD) and cancer have been identified as risk factors for severe and fatal cases of COVID-19, making vaccination in these patients a priority. Patients suffering from ESKD have a significantly weaker response to common vaccines than general population. However, humoral and cellular immune responses after two doses of RNA-based vaccine BNT162b2 (Pfizer–BioNTech) have been poorly explored in this vulnerable population.Case presentationA 69-year-old male patient was followed for ESKD and myeloma. He developed a severe SARS-CoV-2 pneumonia twenty days after two doses of BNT162b2 vaccine. Whole genome sequencing found that the virus belonged to the 20I/501Y.V1 clade. A serology draws eight days after the 2nd vaccine dose showed positive RBD IgG without neutralizing activity. A serum specimen sampled thirty days after the onset of SARS-CoV-2 infection showed seroconversion against both RBD and N antigens. This specimen was shown to exhibit a frank neutralizing activity. The QuantiFERON® SARS-CoV-2 (Qiagen) showed a positive specific cellular response although the QuantiFERON monitor displayed a weak cellular response. ConclusionsImpaired immunity due to renal failure probably explain the severe pneumonia despite vaccination. The fact that the patient developpe a neutralizing activity and a cellular response after a third stimulation by infection may suggest to systemically administrate a third dose of vaccine in ESKD patients.
Parvovirus Enteritis and Other Risk Factors Associated With Persistent Gastrointestinal Signs in Dogs Later in Life: a Retrospective Cohort Study
Authors: Takada Kanae , Flemming Anne M. , Voordouw Maarten J. , Carr Anthony P.
Published: July 2021

Background: Parvoviral enteritis is a viral gastrointestinal (GI) infection of dogs. Recovery from PE has been associated with persistent GI signs. The objectives of this study were: (i) To determine whether dogs that have recovered from PE (post-parvo dogs) had an increased risk of persistent GI signs compared to uninfected controls. (ii) To investigate the lifestyle and clinicopathologic factors that are associated with persistent GI signs in post-parvo dogs. Methods: Eighty-six post-parvo dogs and 52 age-matched control dogs were enrolled in this retrospective cohort study. The owners were interviewed about the health and habits of their dogs using a questionnaire. We used logistic regression to test whether parvovirus enteritis and other risk factors are associated with general health problems in all dogs and with persistent GI signs in post-parvo dogs.Results: The prevalence of persistent GI signs was significantly higher in post-parvo dogs compared to control dogs (57% vs 25%, P < 0.001). Markers of disease severity such as neutropenia, low body temperature, and treatment with an antiemetic medication (metoclopramide) were significant risk factors for persistent GI signs in post-parvo dogs. Persistent GI signs in post-parvo dogs was a risk factor for health problems in other organ systems.Conclusions: Parvovirus enteritis is a significant risk factor for persistent GI signs in dogs highlighting the importance of prevention. The risk factors identified in the present study may guide future investigations on the mechanisms that link parvovirus enteritis to chronic health problems in dogs.
Three-dimensional Imaging of Nanoplasma by Ion Nanoscopy
Authors: Han Xu , Huang Xiang , Zhang Qingbin , Fu Xianglong , Liu Kunlong , Lan Pengfei , Zhou Yueming , Li Min , Cao Wei , Lu Peixiang
Published: July 2021

The remarkable abilities of laser-irradiated nanostructures to emit X-ray photons, accelerate charged particles, and launch shock waves for multiple applications are primarily governed by a localized plasma near the surface. However, the full-spatially resolving the localized plasma is still challenging due to the difficulty of measuring the three-dimensional (3D) momentum of ions generated from partially or fully ablated nanostructures in high-intensity laser fields. Here, we bridge this gap by introducing ion nanoscopy based on the tomographic reconstruction of the 3D momentum of ions emitted from constantly refreshed aerosolized TiO2 nanospheres. The measured 3D ion momenta map the localized plasma charge well through an electrostatic repulsion model. A pronounced variation in localized plasma charge across the nanosphere surface is obtained, which also extends the idea of the combined action of external and internal fields on plasma formation. This work represents an advance in understanding plasma generation from nanostructures and in the probing, visualization, and manipulation of localized nanoplasmas.
A 400-Gb/s WDM-PAM4 OWC System Through the Free- Space Transmission With a Water-Air-Water Link
Authors: Lu Hai-Han , Li Chung-Yi , Huang Xu-Hong , Chang Poh-Suan , Chen Yu-Ting , Lin Yan-Yu , Liu Chen-Xuan , Ko Ting
Published: July 2021

A 400-Gb/s wavelength-division-multiplexing (WDM) four-level pulse amplitude modulation (PAM4) optical wireless communication (OWC) system through a 200-m free-space transmission with either an 8.8-m piped water-air-piped water link or a 6.5-m turbid water-air-turbid water link is attainably constructed. Incorporating PAM4 modulation with an 8-wavelength WDM scheme greatly increases the total transmission rate of the WDM-PAM4 OWC system to 400 Gb/s (50 Gb/s/λ × 8 λs). By employing doublet lenses in free-space transmission, a laser beam reducer/expander and a reflective spatial light modulator (SLM) with an angle expander through the water-air-water link, high bit error rate performance and acceptable PAM4 eye diagrams are obtained. Using a reflective SLM with an angle expander not only adaptively adjusts the laser beam, but also effectively solves the marine engineering problems. This demonstrated WDM-PAM4 OWC system outperforms existing OWC systems through free-space transmission with an air-water-air link due to its ability to resolve the practical engineering problems in actual marine environments.
TRPV1 modulation of immune response in metastatic breast carcinoma: Enhanced inflammatory response may hinder therapeutic potentials of TRPV1 agonists
Authors: Erin Nuray , Akman Muhlis , Haksever Seren
Published: July 2021

Background and Purpose: The transient receptor potential vanilloid 1 (TRPV1) ion channels enhance cytotoxic immune response and may have therapeutic potential in cancer treatment. Hence, we here determined how activation of TRPV1 alters immune response of tumor-bearing mice.Experimental Approach: Three different metastatic subset of 4T1 breast carcinoma cells were used to induce tumors in Balb-c mice. Mix leukocyte cultures (MLCs) using spleens and draining lymph nodes were prepared and stimulated with various challenges. Effects of four different TRPV1 agonists, antagonist (AMG9810) and Gambogic Amide (GA), a TrkA agonist that sensitizes TRPV1, on secreted levels of cytokines were determined.Results: MLCs of tumor-bearing mice secreted markedly higher levels of IL-6 and lower levels of IFN-γ compared to control mice. We observed differential effects of TRPV1 agonists, antagonist and GA in control and mice bearing different subset of metastatic cells. TRPV1 and TrkA agonists increased IFN--γ and IL-17 secretion in control mice while they markedly increased IL-6 secretion and suppressed IFN--γ secretion in tumor-bearing mice. Unexpectedly, AMG9810 acted as an inverse agonist and did not antagonize the effects of TRPV1 agonists and GA did not sensitize TRPV1 channels. Conclusions: Our results demonstrate constitutive activity of TRPV1 in immune cells, suggesting cross activation. Excessive chronic activation of TRPV1 in immune cells in the presence of metastatic breast carcinoma may have detrimental effects. Unexpected findings further document that a drug can have multiple intrinsic activities and depending on surrounding factors can act on the same receptor as an agonist, antagonist or inverse agonist.
Predictors of Prognosis of Surgically Resected Brain Metastasis from Lung Cancer with a Focus on Brain Recurrence
Authors: Byun Joonho , Kim Moinay , Lee Seungjoo , Song Sang Woo , Kim Young-Hoon , Hong Chang Ki , Kim Jeong Hoon
Published: July 2021

Purpose: There are many considerations to decide surgical treatment in lung cancer-brain metastasis. Herein, we analyzed survival and predictors of brain recurrence after surgical resection of brain metastasis from lung cancer. Methods: A total of 224 metastatic brain tumors from patients with lung cancer were analyzed. Results: There were 138 (61.6%) male and 86 (38.4%) female patients; 197 patients with non-small cell lung cancer (NSCLC) and 27 with small cell lung cancer (SCLC). The rate of postoperative complications was 4.9%. The 1-year and 2-year overall survival (OS) was 57% and 43%, respectively. The 6-month and 1-year progression-free survival (PFS) of local recurrence was 42% and 20%, respectively. In NSCLC and SCLC groups, the difference of PFS of local recurrence according to adjuvant resection bed irradiation was not significant (1-year: 20% vs. 22%, p=0.8) and (1-year: 14% vs. 25%, p=0.16), respectively. Whole-brain irradiation did not show a significant difference of distant recurrence (6-month: 54% vs. 60%, p=0.13). In predictor analysis, female sex was a favorable prognostic factor for OS, while SCLC histology and postoperative neurological deficits were poor prognostic factors in univariate analysis. Conclusions: SCLC histology and postoperative complications are negative predictors for OS. Adjuvant irradiation did not show effectiveness to reduce local and distant recurrence.
Unveiling the Past, Current and Future of Global Sustainable Livelihoods Research by Visual and Quantitative Analysis
Authors: Li Tong , Cui Lizhen , Singh Ranjay K. , Fava Francesco , Xu Zhihong , Kumar Shalander , Song Xiufang , Tang Li , Wang Yanfen , Hao Yanbin , Cui Xiaoyong
Published: July 2021

Sustainable Livelihoods (SLs) is now a high-priority field in global environmental change research, becoming one of the key research paradigms in sustainability science increasingly and an important component of the Sustainable Development Goals. A Scientometrics analysis based on Science Citation Index-Expanded was performed to understand the research trends and areas in SLs studies. A total of 6441 papers related to SLs studies and 265, 759 references published from 1991 to 2020 were selected as the research objects. Using advanced quantitative analysis tools such as CiteSpace and VOSviewer, we quantify and visualize the characteristics and evolution of the literature in the field of SLs research, to clarify the historical research characteristics, knowledge base, and future research trends. The results show that the annual number of documents increased exponentially since 1991. Ecological sciences and ecology were the most popular Web of Science research areas. The institution with the greatest research documents and most citations was the CGIAR. The most influential journal is Word Development. Singh R.K., Shackleton C.M., was the most productive author. Six clusters of research areas were determined by keyword co-occurrence analysis. The results of the evolution of research hotspots show that the four tags currently still active. We also detected 11 directions of SLs research studies based on the keywords’ score relevance, which has allowed the iden-tification of future lines of research with more importance. These results can help related researchers better understand the past current and future of SLs research studies, which is significant for achieving livelihoods sustainability.
Access to Primary Healthcare Services in Conflict-Affected Fragile States: A Subnational Descriptive Analysis of Educational and Wealth Disparities in Cameroon, Democratic Republic of Congo, Mali, and Nigeria
Authors: Ramadan Marwa , Tappis Hannah , Uribe Manuela Villar , Brieger William
Published: July 2021

Background
Measuring and improving equitable access to care is a necessity to achieve universal health coverage. Pre-pandemic estimates showed that most conflict-affected and fragile situations were off-track to meet the Sustainable Development Goals on health and equity by 2030. Yet, there is a paucity of studies examining health inequalities in these settings. This study addresses the literature gap by applying a conflict intensity lens to the analysis of disparities in access to essential Primary Health care (PHC) services in four conflict-affected fragile states: Cameroon, Democratic Republic of Congo, Mali and Nigeria.
Methods
For each studied country, disparities in geographic and financial access to care were compared across education and wealth strata in areas with differing levels of conflict intensity. The Demographic Health Survey (DHS) and the Uppsala Conflict Data Program were the main sources of information on access to PHC and conflict events, respectively. To define conflict intensity, household clusters were linked to conflict events within a 50-km distance. A cut-off of more than two conflict-related deaths per 100,000 population was used to differentiate medium or high intensity conflict from no or low intensity conflict. We utilized three measures to assess inequalities: an absolute difference, a concentration index, and a multivariate logistic regression coefficient. Each disparity measure was compared based on the intensity of conflict the year the DHS data was collected.
Results
We found that PHC access varied across subnational regions in the four countries studied; with more prevalent financial than geographic barriers to care. The magnitude of both educational and wealth disparities in access to care was higher with geographic proximity to medium or high intensity conflict. A higher magnitude of wealth rather than educational disparities was also likely to be observed in the four studied contexts. Meanwhile, we only found few examples of statistical interaction between conflict intensity and either wealth or educational disparities in access to care.
Conclusion
Both educational and wealth disparities in access to PHC services can be exacerbated by geographic proximity to organized violence. This paper provides additional evidence that, despite limitations, household surveys can contribute to healthcare assessment in conflict-affected and fragile settings.
İtfaiye İstasyonu İhtiyacının Yedek Çift Kapsama Yaklaşımıyla Belirlenmesi ve Yer Seçimi: Trabzon Kenti Örneği
Authors: KUKU Şeyda , TÜRK Ersin
Published: July 2021

İtfaiye istasyonları kentsel alanda can ve mal güvenliğini sağlayan acil hizmet birimleridir. Bu hizmetin ihtiyaca hızlı yanıt verecek şekilde yüksek hizmet düzeyi ile sunulması kamu güvenliği açısından çok önemlidir. Ancak, imar mevzuatında itfaiye istasyonlarının planlanmasına yönelik herhangi bir hükme yer verilmediğinden, imar planlarında ve uygulamada itfaiye istasyonlarının sayısına, büyüklüklerine ve konumlarına ilişkin kararlar yetkili belediyenin takdirine bırakılmıştır. Oysa, itfaiye istasyonlarının planlanmasına ilişkin literatür incelendiğinde, tepki süresi, kapsama alanı, nüfus vb. ölçütler dikkate alınarak kent bütününde itfaiye istasyonlarının planlanması önerilmektedir. Bu çalışmanın amacı; Yedek Çift Kapsama yaklaşımıyla, tüm planlama alanına 5 dakika tepki süresi içinde hizmet verilebilecek ve mahallenin yangın risk sınıfına göre literatürdeki 5, 8, 10, 15 dakika erişim süreleri içinde ikinci bir itfaiye istasyonunun yedek kapsamında olacak şekilde en az itfaiye istasyon sayısını ve bu istasyonlara uygun kamusal alanları yürürlükteki nazım imar planında belirlemektir. Trabzon’un merkez ilçesi Ortahisar imar planı sınırları, çalışma alanı olarak seçilmiştir. Çalışma kent içinde itfaiye istasyonu ihtiyacının belirlenmesine ve yer seçimi sürecine katkı sağlayacaktır. Çalışma sonucunda, var olan itfaiye istasyonun mevcut yerinde kalması gerektiği, kentin doğusunda ve batısında iki itfaiye istasyonuna daha ihtiyaç olduğu ve itfaiye istasyonlarının planlanmasına yönelik olarak Mekânsal Planlar Yapım Yönetmeliğinde düzenlemeler yapılması gerektiği sonuçlarına varılmıştır.
Kısa Dönemli Hidrolojik Tahmin Sistemi Uygulaması
Authors: UYSAL Gökçen , SENSOY Aynur , ŞORMAN Arda , ERTAŞ Mustafa Cansaran
Published: July 2021

Bu çalışmanın amacı kar erimesinin etkili olduğu dağlık memba havzaları için kısa dönemli akım tahmin sisteminin geliştirilmesidir. Çalışma alanları olarak seçilen dağlık Fırat ve Seyhan Havzaları, yüksek su potansiyeli, bu potansiyeli besleyen kar erimeleri, mansapta büyük ve önemli su yapılarının bulunması ile ön plana çıkmaktadırlar. Yağış-akış ilişkisinin simülasyonu için dağlık bölge uygulamalarında literatürde yaygın olarak kullanılan HBV modeli seçilmiştir. Sayısal Hava Tahmin (SHT) verisi olarak Mesoscale Model 5 (MM5) ve Weather Research and Forecast (WRF) model sonuçları kullanılmıştır. Hidrolojik model parametrelerinin gözlenen yağış, sıcaklık ve akım verileriyle kalibrasyon/doğrulama işleminin yapılmasının ardından, analizleri yapılan SHT verilerinin girdi olarak kullanılması ile 1 ve 2 günlük akım tahminleri elde edilmiştir. İleriye dönük akım tahminleri Delft-FEWS platformunda kapalı döngü şeklinde çalıştırılarak, geçmiş dönem tahmin simülasyonları gerçekleştirilmiş ve akım gözlemleri ile kıyaslanarak performans değerlendirmesi yapılmıştır. Elde edilen sonuçlar havzaların akış aşağısında bulunan su yapılarının daha verimli işletilmesine ve böylece ülke ekonomisine katkı sağlayabilecektir.
Doğu Karadeniz Orman Yangınlarının Uzun Dönem Meteorolojik Parametrelerle Değerlendirilmesi
Authors: COSKUNER Kadir Alperen
Published: July 2021

Bu çalışmada, Doğu Karadeniz Bölgesinde 1987-2020 yılları arasında gerçekleşen orman yangınlarına ilişkin yangın sayısı ve yanan alan miktarları ile uzun dönem meteorolojik parametreler arasındaki ilişki incelenmiştir. Bu amaçla, Giresun, Trabzon ve Artvin Orman Bölge Müdürlüğü sınırlarında 1987-2020 yılları arasında gerçekleşen ve 7340,7 hektar alanda etkili olan 1560 orman yangını ile yıllık ortalama sıcaklık, bağıl nem, rüzgâr hızı, yıllık toplam yağış miktarları ve hesaplanan İsveç Angström Yangın İndeks değerleri analiz edilmiştir. Sonuçlar incelendiğinde, yıllık yangın sayısı ile yıllık ortalama sıcaklık değerleri arasında anlamlı pozitif, bağıl nem ve yağış miktarı arasında ise anlamlı negatif korelasyon elde edilmiştir. Yıllık yangın sayısı ile yıllık ortalama rüzgâr hızı arasında anlamlı bir ilişki bulunamamıştır. Angström yangın indeks değeri azaldıkça yangın riski artmaktadır. Yapılan korelasyon analizi sonucunda yangın sayısı ile Angström İndeks değerleri arasında anlamlı negatif korelasyon elde edilmiştir. Yanan alan miktarı ile yıllık ortalama sıcaklık, bağıl nem, rüzgâr ve Angström İndeksi değerleri arasında anlamlı bir ilişki bulunamamış, yıllık toplam yağış miktarı ile anlamlı negatif korelasyon elde edilmiştir. Doğu Karadeniz Bölgesi 1987-2020 yılları arasındaki Angström yangın indeks değerlerindeki azalan eğilim ve artan yangın sayıları değerlendirildiğinde, gelecekte yangınların bölge ormanlarında önemli bir orman koruma problemi oluşturabileceği öngörülebilmektedir.
Implementasi Algoritma Dijkstra untuk Mencari Rumah Kost Terdekat di Kodya Yogyakarta Berbasis Android
Authors: Pattriskak Bhernardin Erryco Gagah , Santosa R.Gunawan , Chrismanto Antonius Rachmat
Published: July 2021

Permasalahan yang sering dihadapi oleh para mahasiswa terutama mahasiswa pendatang adalah sulitnya untuk memperoleh tempat tinggal, salah satunya adalah rumah kost. Namun beberapa mahasiswa memiliki pertimbangan tertentu dalam memilih kos-kosannya salah satunya adalah jarak tempat kost dari universitas tertentu. Penelitian ini akan mencoba mengimplementasikan algoritma Dijkstra untuk melakukan pencarian kost terdekat di Android, pada aplikasi ini juga akan terdapat fitur pencarian jalur terpendek, filter harga maksimal, dan filter jarak maksimal. Algoritma Dijkstra merupakan salah satu algoritma untuk melakukan pencarian jarak terkecil dan jalur terpendek. Hasil pencarian jarak kost terdekat dan jalur terpendek akan dibandingkan dengan hasil dari Google Maps, proses lamanya waktu pencarian pada sistem juga akan dicatat. Dari penelitian ini algoritma Dijkstra berhasil diimplementasikan untuk melakukan pencarian kost terdekat, pencarian kost berdasarkan filter, dan pencarian jalur terpendek di Android. Pada pengujian pencarian jarak kost terdekat didapatkan hasil bahwa algoritma Dijkstra dalam mencari jarak terkecil hampir mendekati data dari Google Maps dengan rata-rata selisih jarak sebesar 6,1 m. Pengujian ini juga menemukan bahwa semakin jauh jarak dan jalur rumah kost yang dicari menggunakan algoritma Dijkstra maka akan semakin lama waktu pencariannya dikarenakan semakin banyaknya vertek yang dikerjakan.
Pemanfaatan Seamless Wireless (EoIP) dan GPS pada Sistem Peringatan Perlintasan Kereta Tanpa Palang Pintu
Authors: Pramantha Dio , Indriyanta Gani , Saputra Laurentius Kuncoro Probo
Published: July 2021

Perlintasan kereta liar tanpa palang pintu dan tanpa penjaga merupakan awal mula sering terjadinya kecelakaan di perlintasan kereta api. Salah satu solusi untuk menyelesaikan permasalahan ini dengan pembangunan sistem otomatis peringatan kedatangan kereta dengan memanfaatkan teknologi seamless wireless Ethernet over Internet Protocol (EoIP). Penelitian ini dilakukan dengan pengujian prototype di lingkungan UKDW dengan panjang pelintasan kurang lebih 70 - 80 meter, menggunakan 1 MCU(Micro Controller Unit) ESP8266 dan 1 GPS Module yaitu node kereta, 2 MCU, 2 unit LCD module, 2 Servo motor dan 2 Buzzer menjadi 2 node perlintasan kereta. Sistem ini diuji coba sebanyak 30 kali dengan checklist pengujian. Pengujian dimulai saat node kereta mengirimkan informasi dalam bentuk longitude dan latitude ke server lalu server akan menghitung jarak antara node kereta dengan setiap node perlintasan kemudian hasil jarak tersebut akan di kirim ke setiap node perlintasan kereta, akan terjadi pengecekan jarak di setiap node perlintasan kereta, pada jarak yang telah ditentukan palang akan ditutup ataupun dibuka. Dari 30 kali percobaan disimpulkan bahwa sistem otomatis peringatan kedatangan kereta dapat mendeteksi kedatangan kereta dan telah berhasil dibangun dengan benar dan berjalan sesuai flow sistem yang sudah dirancangkan. Dilengkapi dengan pemanfaatan Teknologi seamless wireless EoIP yang memungkinkan pembangunan jaringan bahkan di titik buta tidak dapat dijangkau oleh  operator seluler ataupun GSM. Oleh karena itu seamless wireless EoIP ini sangat cocok dalam membantu pembangunan sistem peringatan kedatangan kereta api dengan palang otomatis  dibuktikan dengan setiap alat dapat terhubung dan tidak terputus selama 30 kali percobaan.
Pembangunan Model Pengetahuan Kerajinan Tradisional Indonesia dengan Pendekatan On-To-Knowledge
Authors: Muryanti Ni Luh , Virginia Gloria , Susanto Budi , Proboyekti Umi
Published: July 2021

Kerajinan tradisional adalah karya yang dibuat dengan peralatan sederhana dan berbahan alami. Kerajinan tradisional terdiri dari anyaman, batik, gerabah, kain tenun, kerajinan kayu dan kerajinan perak. Jenis kerajinan tradisional yang ada berbanding terbalik dengan informasi yang tersedia mengenai kerajinan tradisional Indonesia. Oleh karena itu sangat penting untuk memperkenalkan dan mendokumentasikan kerajinan tradisional pada masyarakat Indonesia. Salah satu cara untuk mendokumentasikan kerajinan tradisional Indonesia yaitu menggunakan semantic web. Semantic web mampu mengelola sekumpulan data dan model yang dinamis sehingga dapat memberikan keterbukaan akses infromasi. Pengetahuan tentang kerajinan tradisional Indonesia direpresentasikan ke bentuk OWL. Pada penelitian ini, penulis menggunakan metodologi On-To-Knowledge untuk membangun ontologi kerajinan tradisional Indonesia. Dalam metodologi On-To-Knowledge terdapat 5 tahapan, namun penulis hanya menggunakan 4 tahapan yaitu tahap feasibility study, kick off, refinement, dan evaluation. Tahap feasibility study bertujuan untuk melakukan studi kelayakan terhadap sistem yang akan dibangun dengan mengidentifikasi masalah, pengguna sistem dan use case. Tahap kick-off bertujuan untuk mendefinisikan kebutuhan ontologi kerajinan tradisional Indonesia dan sumber pengetahuan yang digunakan. Tahap refinement bertujuan untuk melakukan pemodelan ontologi kerajinan tradisional Indonesia yang dilakukan dengan beberapa tahap yaitu ekstraksi pengetahuan secara manual, membuat description logic dan pembuatan T-Box. Evaluasi adalah tahap pengujian menggunakan reasoner HermiT pada aplikasi protégé, DL Query dan completeness check.
THE SENSE OF SELF EFFICACY OF PRE-SERVICE ENGLISH TEACHERS IN EFL CONTEXT
Authors: Safitri Devina Eka
Published: July 2021

This study aims to describe the sense of self-efficacy of pre-service teachers in the context of EFL. This issue needs to be discussed because of the importance of self-efficacy in teaching for the pre-service teacher. The study used the Teacher Sense of Efficacy Scale (TSES) questionnaire as the instrument. There were 103 respondents participated in this study. The results showed that pre-service English teachers were more effective on instructional strategy with an average score of 3.7840 of the overall sense of efficacy. Then, followed by student engagement efficacy with an average score of 3.7561, and the last one is class management with an average score of 3.7318. Based on the data obtained, it shows that the students' sense of efficacy is at a moderate level.
STUDENTS’ PERCEPTION TOWARDS THE IMPLEMENTATION OF ONLINE FORMATIVE ASSESSMENT IN ENGLISH LEARNING
Authors: Kristiyanti Komang Lisna , Santosa Made Hery , Pratiwi Ni Putu Astiti
Published: July 2021

The Indonesian government policy due to the emergence of the COVID-19 pandemic requires all students and teachers to carry out the learning process online. Starting from various learning strategies to the assessment process must be carried out by applying an online system. In line with this policy, this study was conducted with the aim of investigating the implementation of one type of assessment, namely formative assessment in online learning situations. This study focuses on students’ perceptions of the implementation of formative assessment in English learning. By using a mixed-method research design, data collection was carried out through survey and interview methods. The samples of this study were 215 students of a Junior High School in Bali, Indonesia and involved 8 students from the entire sample as participants in the interview. The survey results showed that students had a positive perception of the implementation of online formative assessment. This is also supported by information obtained in the interview process, in which students feel that this type of online formative assessment is comfortable to carry out, especially because of the use of simple and easy tools. In addition, students also feel that there are things that make online formative assessment less effective, such as the unavailability of feedback which also causes students to be less interested in this type of assessment. Through this study, it is hoped that it can provide various information for students and teachers for the purpose of improving the quality of the implementation of formative assessment in English learning.
A review of the design and implementation of Ghana's National Water Policy (2007)
Authors: Frimpong Josephine , Adamtey Ronald , Pedersen Anders Branth , Wahaga Esther , Jensen Anne , Obuobie Emmanuel , Ampomah Ben
Published: July 2021

Access to water is a matter of daily survival for people around the world. Water is crucial for human survival and also central to the development of every nation. The recent literature on world water suggests that the water crisis being experienced is related to governance and not a real crisis of scarcity and stress. This paper aims at identifying water governance practices and the challenges associated with water governance in Ghana. The paper reviews the literature on the implementation of policy directives and actions with specific focus on water resources governance aspects of Integrated Water Resources Management (IWRM) in Ghana. Ghana's National Water Policy is expected to turn the fortunes of the country around in terms of water resources management. Concerning water resources management, the policy advocates for an IWRM approach. Since its implementation, certain setbacks have been challenging the effectiveness of the policy, such as inadequate institutional capacity, inadequate funding, ineffective enforcement of existing regulations, inadequate legal framework, and lack of adequate data. The paper suggests, among other things, the building of both human and institutional capacity, and making the environment a government priority, as ways to contribute to the effective implementation of the National Water Policy.
Wprowadzenie. U podstaw syntezy wiedzy. O szlifowaniu narzędzi myślenia wedle Jana Franciszka Drewnowskiego
Authors: Świętorzecka Kordula , Adamczyk Michał
Published: July 2021

Jan Franciszek Drewnowski (1896–1978) był filozofem zaliczanym do środowiska szkoły lwowsko-warszawskiej, współtwórcą koła krakowskiego (obok ks. J. Salamuchy, o. J.M. Bocheńskiego, B. Sobocińskiego), oficerem wojska polskiego (uczestnikiem wojen światowych i wojny w roku 1920), pracownikiem wydawnictw technicznych. Drewnowski doktoryzował się u T. Kotarbińskiego, jego niedoścignionym mistrzem był Stanisław Leśniewski. Był jednym z pierwszych słuchaczy akademickich wykładów Leśniewskiego. Studiował na Wydziale Filozoficznym Uniwersytetu Warszawskiego: matematykę, logikę matematyczną i – jak to wtedy nazywano – filozofię naukową. Tam właśnie spotkał ks. Jana Salamuchę, który zaimponował Drewnowskiemu naukową erudycją, a intelektualną uczciwością skierował go od ateizmu ku katolickiej mistyce. W ten sposób Drewnowski wpisał się w grono intelektualnych konwertytów XX wieku, co ma znaczenie także dla jego dorobku.
The Plasticity of Circulating Tumor Cells in Ovarian Cancer During Platinum-containing Chemotherapy
Authors: Gening Snezhanna Olegovna , Dolgova Dinara Rishatovna , Abakumova Tatyana Vladimirovna , Antoneeva Inna Ivanovna , Gening Tatyana Petrovna
Published: July 2021

Background:

Circulating Tumor Cells (CTCs) are a potential source of metastases and
relapses. The data on molecular characteristics of Ovarian Cancer (OC) CTCs are limited.

Objective:

This study aims to assess the TGFβ, CXCL2, VEGFA and ERCC1 expressions in two
OC CTC subpopulations before and during chemotherapy (CT), and their relation to clinical characteristics.

Methods:

Two CTCs subpopulations (EpCAM+CK18+E-cadherin+; EpCAM+CK18+Vimentin+)
were enriched using immunomagnetic separation before treatment and after 3 cycles of platinumcontaining
CT. The expression of mRNA was assessed using RT-qPCR.

Results:

The study included 31 I-IV stage OC patients. During CT, TGFβ levels increased in both
fractions (p=0.054) compared with the initial levels. ERCC1 expression in E-cadherin+ CTCs was
higher during neoadjuvant than adjuvant CT (p=0.004). CXCL2 level in E-cadherin+ CTCs increased
(p=0.038) during neoadjuvant CT compared with the initial. TGF-β expression in vimentin+
CTCs during CT was negatively correlated to disease stage (p=0.003). Principal component
analysis before CT revealed a component combining VEGFA, TGFβ, CXCL2, and a component
with ERCC1 and VEGFA; during CT, component 1 contained ERCC1 and VEGFA, and component
2 - TGFβ and CXCL2 in both fractions. Increased ERCC1 expression in E-cadherin+ CTCs
during CT was associated with decreased Progression-Free Survival (PFS) (HR 1.11 (95% CI
1.03-1.21, p=0.009) in multivariate analysis.

Conclusion:

EpCAM+ OC CTCs are phenotypically heterogeneous, which may reflect variability
in their metastatic potential. CT changes the molecular characteristics of CTCs. Expression of
TGFβ in EpCAM+ CTCs increases during CT. High ERCC1 expression in EpCAM+CK18+E-cadherin+
CTCs during CT is associated with decreased PFS in OC.
Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Authors: Merheb Diala , Dib Georgette , Zerdan Maroun Bou , Nakib Clara El , Alame Saada , Assi Hazem I.
Published: July 2021

:

Peripheral neuropathy comes in all shapes and forms and is a disorder which is found in
the peripheral nervous system. It can have an acute or chronic onset depending on the multitude of
pathophysiologic mechanisms involving different parts of nerve fibers. A systematic approach is
highly beneficial when it comes to cost-effective diagnosis. More than 30 causes of peripheral neuropathy
exist ranging from systemic and auto-immune diseases, vitamin deficiencies, viral infections,
diabetes, etc. One of the major causes of peripheral neuropathy is drug-induced disease,
which can be split into peripheral neuropathy caused by chemotherapy or by other medications.
This review deals with the latest causes of drug-induced peripheral neuropathy, the population involved,
the findings on physical examination and various workups needed and how to manage each
case.
Network-Based Analysis Reveals Gene Signature in Tip Cells and Stalk Cells
Authors: Li Chen , Xu Lingyun
Published: July 2021

Background:

Angiogenesis occurs during various physiological or pathological processes such as wound
healing and tumor growth. Differentiation of vascular endothelial cells into tip cells and stalk cells initiates the formation
of new blood vessels. Tip cells and stalk cells are endothelial cells with different biological characteristics and
functions.

Objective:

The aim of this study was to determine the mechanisms of angiogenesis by exploring differences in gene
expression of tip cells and stalk cells.

Methods:

Raw data were retrieved from NCBI Gene Expression Omnibus (GSE19284). Data were reanalyzed using
bioinformatics methods that employ robust statistical methods, including identification of differentially expressed
genes (DEGs) between the stalk and tip cells, Weighted Gene Correlation Network Analysis (WGCNA), gene ontology
and pathway enrichment analysis using DAVID tools, integration of Protein-Protein Interaction (PPI) networks and
screening of hub genes. DEGs of stalk and tip cells were grouped as dataset A. Gene modules associated with differentiation
of stalk and tip cells screened by WGCNA were named dataset B. Further, we retrieved existing markers of
angiogenesis from previous experimental studies on tip and stalk cells which we called dataset C. Intersection of
datasets A, B and C was used as a candidate gene. Subsequently, we verified the results applying Quantitative Polymerase
Chain Reaction (Q-PCR) to our clinical specimen. In general, the Q‐PCR results coincide with the majority of the
expression profile.

Results:

We identified five candidate genes, including ESM1, CXCR4, JAG1, FLT1 and PTK2, and two pathways,
including Rap1 signaling pathway and PI3K-Akt signaling pathway in vascular endothelial cells that differentiate into
tip cells and stalk cells using bioinformatics analysis.

Conclusion:

Bioinformatics approaches provide new avenues for basic research in different fields such as angiogenesis.
The findings of this study provide new perspectives and a basis for the study of molecular mechanisms of vascular
endothelial cell differentiation into stalk and tip cells. Genes and pathways identified in this study are potential biomarkers
and therapeutic targets for angiogenesis in the tumor.
Development of a phenomenological RBE calculation model for carbon ion radiotherapy and high-precision clinical analysis
Authors: Kohno Ryosuke
Published: July 2021

Cancer can reduce quality of life, place strain on families and even kill. Treatment methods are not always effective nor precise and involve either surgical removal of cancerous tissues or a combination of drugs and radiation. Advances in physics are providing new hope for treatment
options in the form of radiation and, specifically, particle therapy, which includes proton beam therapy and carbon ion radiotherapy (CIRT). This improves treatment precision as the beam can be targeted so that it kills cancer and not the surrounding tissue. Ryosuke Kohno, Department of Accelerator
and Medical Physics, National Institutes for Quantum and Radiological Science and Technology, Japan, is interested in how applied physics can bridge with medicine, becoming medical physics. He has developed several beam therapies protocols over the years and is particularly interested in CIRT
and how the technique can be improved. Kohno is currently working on fine tuning a model that can be optimally calibrated to attack all types of tumours. He and his team are also working on Intensity-Modulated Composite Particle Therapy (IMPACT). Kohno is collaborating with a multidisciplinary
radiotherapy team and his interdisciplinary research involves the integration of radiation/medical physics, radiation biology and radiation oncology. He is also assisting early-stage researchers so that the next-generation of researchers can form new bridges between basic science and medicine.