bluuebunny/crossref_metadata_2025 huggingface dataset:
Multicomponent Mathematical Model for Tumor Volume Calculation with Setup Error Using Single-Isocenter Stereotactic Radiotherapy for Multiple Brain Metastases
Authors: Nakano Hisashi , Shiinoki Takehiro , Tanabe Satoshi , Nakano Toshimichi , Takizawa Takeshi , Utsunomiya Satoru , Sakai Madoka , Tanabe Shunpei , Ohta Atsushi , Kaidu Motoki , Nishio Teiji , Ishikawa Hiroyuki
Published: October 2022

Purpose
We evaluated the tumor residual volumes considering six degrees-of-freedom (6DoF) patient setup errors in stereotactic radiotherapy (SRT) with multicomponent mathematical model using single-isocenter irradiation for brain metastases.
Methods
Simulated spherical gross tumor volumes (GTVs) with 1.0 (GTV 1), 2.0 (GTV 2), and 3.0 (GTV 3)-cm diameters were used. The distance between the GTV center and isocenter (d) was set at 0–10 cm. The GTV was simultaneously translated within 0–1.0 mm (T) and rotated within 0°–1.0° (R) in the three axis directions using affine transformation. We optimized the tumor growth model parameters using measurements of non-small cell lung cancer cell lines' (A549 and NCI-H460) growth. We calculated the GTV residual volume at the irradiation's end using the physical dose to the GTV when the GTV size, d, and 6DoF setup error varied. The d-values that satisfy tolerance values (10%, 35%, and 50%) of the GTV residual volume rate based on the pre-irradiation GTV volume were determined.
Results
The larger the tolerance value set for both cell lines, the longer the distance to satisfy the tolerance value.
Conclusions
In GTV residual volume evaluations based on the multicomponent mathematical model on SRT with single-isocenter irradiation, the smaller the GTV size and the larger the distance and 6DoF setup error, the shorter the distance that satisfies the tolerance value might need to be.
Dentoalveolar, skeletal, pharyngeal airway, cervical posture, hyoid bone position, and soft palate changes with Myobrace and Twin-block: a retrospective study
Authors: Büyükbayraktar Zeynep Çoban , Camcı Hasan
Published: October 2022

Background: The primary aim of this study was to evaluate the dentoalveolar, skeletal, pharyngeal airway, cervical posture,hyoid bone position, and soft palate effects of myobrace and twin block appliances. The second aim was compare the appliances in terms of ease of use by assessing the factors that may influence patient compliance.
Methods: : The study included thirty-six Class II division 1 patients (19 females, 17 males; mean age, 12.14 ± 1.23) who had previously been treated in the Orthodontic clinic at Sivas Cumhuriyet University Faculty of Dentistry. The patients were divided into two groups: Group 1: myobrace (n=18), Group 2: twin block (n=18). The effects of the appliances on the skeletal, dentoalveolar, soft tissue, craniocervical, and other anotomic structures were assessed using 46 measurements, 22 linear and 24 angular, on pre and post-treatment cephalometric radiographs. AudaxCeph 5.0 software (Ljubljana, Slovenia) was used for the analysis. To analyze the changes after one year of treatment, a paired sample t-test and Wilcoxon signed-rank test were used. Intergroup comparison was performed by using the Student t-test and the Mann–Whitney U test.
Results: In the myobrace and twin block groups, there was a significant increase in SNB0 (p=0.004, p=0.001), IMPA0 (p=0.005, p=0.001), and a significant drop in U1/SN0 (p=0.021, p=0.005). The lengths of Cd-Gn (mm), Go-Pg (mm), and Cd-Go (mm) increased significantly in the twin block group (p=0.003, p=0.010, p=0.001), whereas there was no change in the myobrace group. Similarly, there was no significant difference in pharyngeal and soft palate measurements in the Myobrace group, but there was a statistically significant decrease in SP length and SP angle in the twin block group (p=0.001, p=0.006). Increases in SN/OPT0 (p=0.032, p=0.001) and SN/CVT0 (p=0.012, p=0.001) were statistically significant in both groups. Myobrace was more difficult to use while sleeping, whereas twin block caused more nausea.
Conclusions: Both appliances can be used for mandibular advancement. The twin block appliance, on the other hand, was more effective and patient-friendly.
Do Environmental Target Constraints of Local Government affect High-Quality Economic Development? Evidence from China
Authors: Fu Yu , Zhuang Haitao , Zhang Xinfang
Published: October 2022

This paper investigates the impact of local government environmental target constraints on high-quality economic development. We measure the city-level economic high-quality development index, and collate data on environmental target constraints in government work reports of 230 cities from 2004 to 2013. Using the DID model and the instrumental variable method, we find that: (1) environmental target constraints significantly promote the high-quality development of the local economy, when environmental performance is included in the officials’ performance evaluation; (2) environmental target constraints are heterogeneous across regions and have a greater promoting effect on cities in eastern China than in central and western China. The results of a series of robustness tests support these conclusions.
Stakeholder perceptions in Healthcare Delivery Projects: Clinicians and Senior Hospital Management
Authors: Kelly Éamonn V
Published: October 2022

Research question/issue: Addressing the call of past research, this study examines the differences in perceptions of project success criteria held by clinicians and senior hospital management within healthcare service delivery.
Methodology: A survey with 25 five-point Likert scale questions was used to measure stakeholder opinions of project success criteria relating to project efficiency, organizational benefits, project impact, future potential, and stakeholder satisfaction. The study's target population included over 290,000 clinicians and 36,000 senior hospital managers employed in public hospitals in the United States. The survey was distributed through Qualtrics online research panels. Of the 130 responses received, 76 surveys were used to test five hypotheses.
Research findings/insights: Results reveal significant differences in the criteria that each group considers important for measuring and assessing project success. The study lists 12 project success criteria (eight items for project efficiency and four for project impact) for which the perceptions of clinicians and senior hospital management differ.
Theoretical/academic implications: Before this study, no previous research has explored the contrasting perspectives of different internal stakeholder groups regarding project success criteria within a healthcare setting. This study bridges that gap.
Practitioner/policy implications: The study is important because it adds to the existing knowledge regarding project management by contributing to a greater understanding of the different perceptions of project success criteria from the perspective of multiple stakeholder groups in healthcare management.
Macroscopic Model of Hypogravity-Induced Primate Brain Activity via Identification and Analysis of a Neurovisuomotor Performance Pathway
Authors: Ellison Ryan , Matar Mona , Gokoglu Suleyman , Prabhu Raj
Published: October 2022

During long-duration spaceflight, astronauts will experience gravity-transitions (G-transitions) between Earth-gravity (1G) and hypogravity (gravity < 1G), as well as prolonged time in hypogravity environments (i.e., interplanar, the Moon and Mars). The neural substrate underlying coordinated, volitional visuomotor movements like reach-to-grasp is tuned to produce proper movement in 1G. During G-transitions and hypogravity, the brain’s visuomotor control network becomes inadvertently configured through its activity states and interconnections to produce erroneous movements. Thus, the need to identify the brain performance pathways underlying mission-critical behaviors like performing visuomotor tasks and understanding their neurophysiological responses during space travel is critical for astronauts’ safety and mission success. This work utilizes a whole-brain, primate connectome to identify a visuomotor subnetwork, using a novel modularity algorithm. The identified visuomotor subnetwork is analyzed using local graph theory measures, suggesting the parietal cortex intraparietal sulcus (PCIP), superior parietal cortex (PCS), and secondary visual cortex (V2) are structurally positioned to play an important role in network activity and function. 1G macroscopic neural network, neural ensemble models are developed and subjected to emulated hypogravity, analyzed using an unsupervised machine learning technique to cluster simulations into hypogravity-affected and -unaffected groups. Qualitative analyses of region-wise frequency distributions and means between groups suggest the cingulate cortex (CCP), PCS, ventrolateral pre-motor cortex (PMCVL), primary visual cortex (V1), and V2 are hypogravity-affected, producing non-normal neural activity in frequency space. Synthesizing the structural and modeling results, this work suggests PCS and V2 may be viable countermeasure targets, ensuring proper visuomotor performance during and after spaceflight.
Role of OAS gene family in COVID-19 induced heart failure
Authors: Gao Li-Juan , He Zhong-Mei , Li Yi-Ying , Yang Rui-Rui , Yan Min , Shang Xuan , cao Ji-Min
Published: October 2022

Background
COVID-19, the current global pandemic caused by SARS-CoV-2 infection, can damage the heart and lead to heart failure (HF) and even cardiac death. The 2',5'-oligoadenylate synthetase (OAS) gene family encode interferon (IFN)-induced antiviral proteins which is associated with the antiviral immune responses of COVID-19. While the potential association of OAS family with cardiac injury and failure in COVID-19 has not been determined.
Methods
The expression levels and biological functions of OAS gene family in SARS-CoV-2 infected cardiomyocytes dataset (GSE150392) and HF dataset (GSE120852) were determined by comprehensive bioinformatic analysis and experimental validation. The associated microRNAs (miRNAs) were explored from Targetscan and GSE104150 databases. The potential OAS gene family-regulatory chemicals or ingredients were predicted using Comparative Toxicogenomics Database (CTD) and SymMap database.
Results
The OAS genes were highly expressed in both SARS-CoV-2 infected cardiomyocytes and in the failing hearts. The differentially expression genes (DEGs) in the two datasets were enriched in cardiovascular disease and COVID-19 related pathways, respectively. The miRNAs-target analysis indicated that 9 miRNAs could increase the expression of OAS genes. A variety of chemicals or ingredients were predicted regulating the expression of OAS gene family especially estradiol.
Conclusion
OAS gene family is an important mediator of HF in COVID-19 and may serve as a potential therapeutic target for cardiac injury and HF in COVID-19.
Characterization of a glutamate-cysteine ligase in Bombyx mori
Authors: Afrin Wazifa , Furuya Shigeki , Yamamoto Kohji
Published: October 2022

Background: Glutamate cysteine ligase (GCL) is a crucial enzyme involved in the synthesis of glutathione (GSH). Despite various studies on glutathione transferase and its essential role in detoxification and resistance to oxidative stress, GSH synthesis has not been described in silkworms to date. Silkworms form part of the lepidopterans that are considered as a model of agricultural pests. This study aimed to understand the GSH synthesis through the GCL in silkworms so that insecticides can be formulated to tackle agricultural pests.
Methods and Results: Based on the amino acid sequence and phylogenetic tree, this GCL belonged to group 2 and designated bmGCL. Recombinant bmGCL was overproduced and purified to ensure homogeneity. Biochemical studies revealed that bmGCL uses ATP and Mg2+ to ligate glutamate and cysteine, respectively. High expression levels of bmgcl mRNA and GSH were observed in the silkworm fat body after exposure to insecticides and UV-B. Moreover, we found an increase in bmgcl mRNA and GSH content during pupation in the silkworm fat body.
Conclusion: In this study, we found GCL in the silkworm Bombyx mori and its biochemical properties were investigated. These observations indicate that bmGCL might play an important role in the resistance to oxidative stress in B. mori.
Explore the Diagnostic Performance of 2020 C-TIRADS by Comparing With the 2017 ACR-TIRADS guidelines: A Single-Center Study
Authors: cai Miaomiao , chen Libo , lv Xuan , shui Limin , wang Hui
Published: October 2022

Objective
To compare the diagnostic efficacy of the Chinese Thyroid Imaging Reporting and Data Systems(C-TIRADS) with the well-accepted ACR-TIRADS guidelines in identifying benign from malignant thyroid nodules.
Methods
A total of 2064 nodules were collected from 1627 patients undergoing thyroid ultrasonography in our center between October 2019 to November 2021. Nodules were divided into two groups: “≥1cm”and “<1cm”. Ultrasound features of each nodule were observed and recorded by 2 physicians and classified according to the ACR-TIRADS and C-TIRADS guidelines, respectively.
Results
The area under the curve(AUC) of the ACR-TIRADS guideline was higher than that of the C-TIRADS guideline(0.922, P = 0.017), the specificity and positive predictive value of the C-TIRADS guideline were higher (81.64%, 88.72%, all P < 0.05). The diagnostic performance showed similar results for nodules < 1cm. Additionally, the diagnostic efficacy of both guidelines was comparable in nodules ≥ 1cm. The ACR-TIRADS effectively reduced unnecessary biopsies compared with the C-TIRADS (P < 0.05).
Conclusions
There was high agreement between two guidelines for the diagnosis of thyroid nodules, C-TIRADS guidelines had a higher specificity and simplicity while were inferior to the ACR-TIRADS guidelines in terms of reducing the number of biopsies.
Validity and reliability of “My Jump app” to assess vertical jump performance: A meta-analytic review
Authors: Turan Murat , Ulupınar Süleyman , Özbay Serhat , Gençoğlu Cebrail , Savaş Buğra Çağatay , İnce İzzet
Published: October 2022

This systematic review and meta-analysis aims to investigate whether the My Jump app produces valid and reliable results when measuring vertical jump height. To identify potential studies for inclusion in this systematic review and meta-analysis, a search strategy was implemented in the MEDLINE (via PubMed) and Web of Science databases. Meta-analyses of validity were performed in two ways: (1) mean and standard deviations were compared between the My Jump and criterion measurements to assess the agreement of raw scores; (2) correlation coefficients were used to determine the consistency of the rankings within-group in the My Jump and criterion measurements. The meta-analysis of reliability was conducted using intraclass correlation coefficients (ICC). Heterogeneity was determined by Cochrane’s Q statistic and its p-value, I-squared value, and tau-squared value. The risk of publication bias was explored using funnel plot symmetry, and asymmetries were confirmed using the extended Egger’s test. Following the identification of studies providing inclusion criteria, 12 studies were included in the present meta-analysis. The meta-analysis conducted for identifying the agreement between raw scores showed that there was no significant difference between My Jump and the criterion measurements. The meta-analysis for identifying the consistency of the rankings within-group indicated that there was a high correlation between My Jump and criterion devices. Additionally, it is found that the My Jump app had nearly perfect reliability scores. Consequently, this study showed that the My Jump app presented high agreement and consistency scores with reference methods.
Dielectrophoresis-driven Single-cell Manipulation on Microelectrode Array Chips for Accurate Intercellular Interaction Study
Authors: Sawan Mohamad , Zhang Hongyong , Wang Pengbo , Huang Nan , Zhao Lingrui , Su Yi , Li Lingfei , Bian Sumin
Published: October 2022

Single-cell manipulation chips are considered powerful platforms to analyze intercellular interactions and cellular function at single-cell level. Although the conventional cell co-culture models could investigate cell communication to some extent, the role of a single cell requires further analysis. This study focuses on the design and fabrication of a single-cell manipulation platform based on microelectrode array (MEA) chips using dielectrophoresis to build a precise intercellular interaction model on the chip. Single cells were trapped on or transferred between electrodes to achieve exact manipulation. Each electrode on the MEA chip was independently controlled, and the corresponding cellular electrophysiology could be recorded. Multiple influencing factors, including the diameter and depth of microwells, geometry of cells, and voltage amplitude of the control signal, were investigated to determine the optimal condition for cell manipulation. Two typical types of cells, 293T cells and neural cells, were used to test the chip and investigate the influence of electric field on cells. Meanwhile, cell morphology was continuously monitored under microscope. The inappropriate use of the electric field on cells was examined based on the oncosis phenomenon. The obtained preliminary results extended the nature growing model to the controllable level, satisfying the expectation of introducing more elaborated intercellular interaction models.
A Chinese case of CHST3-related skeletal dysplasia and a systematic review
Authors: Liang Hanting , Qi Wenting , Jin Chenxi , Pang Qianqian , Cui Lijia , Jiang Yan , Wang Ou , Li Mei , Xing Xiaoping , Liu Wei , Xia Weibo
Published: October 2022

Purpose
This study described a case with carbohydrate sulfotransferase 3 (CHST3) spondyloepiphyseal dysplasia and summarized all previously reported cases with CHST3-related skeletal dysplasia.
Methods
A 14.8-year-old boy underwent clinical and radiological evaluations, including high-resolution peripheral quantitative computed tomography. The patient and the family members underwent genetic tests. All CHST3-related skeletal dysplasia cases from PubMed and Embase were collected and analysed.
Results
The proband was found to have short lower limbs during a prenatal examination. At 11 years old, he had a compression fracture of L2. Since 13 years of age, he has complained of aggravated pain in the large joints. Physical examination showed a height Z score of -4.94, short limbs, and restricted movement of the elbows and knees. X-rays showed epiphyseal dysplasia of the carpal bones, enlargement of the left elbow and knee joints, and subluxation of the left hip. Echocardiography showed abnormal cardiac valves. Compared with the norm, his total and trabecular volumetric bone mineral density (vBMD) were significantly lower, and the microarchitecture of the trabecular bone was poor at the distal radius and tibia. Two novel missense variants of c.1343T > G and c.761C > G in CHST3 were inherited from his father and mother, respectively. In the systematic review, short stature, limited joint extension, joint pain, and joint dislocation were the most common characteristics associated with mutations of CHST3. Over 90% of pathogenic variants are located in the sulfotransferase domain.
Conclusion
This patient with CHST3-related skeletal dysplasia has progressive joint pain and movement restriction, poor vBMD, and abnormalities of the microarchitecture of the trabecular bone. There is no apparent genotype-phenotype correlation in this disorder.
In vitro and cutting propagation of Heuchera: rapid mass production protocol and correlation between initiating ability the two methods
Authors: Xu Chan , Guo Hang , Wang Zhijing , Chen Yuan
Published: October 2022

There is still a lack of understanding about the efficient mass propagation of multiple Heuchera cultivars leading to a large market gap. And there has been no empirical research on the relationship between propagation methods of cutting and in vitro. In this study, thirteen different cultivars from the genus Heuchera and Heucherella (Heuchera × Tiarella) were successfully rooted by cutting, and calluses and shoots were also successfully inducted from petiole in vitro culture. However, measured indexes varied significantly among cultivars for cutting and tissue culture. Petiole explants treated with cytokinin 6-benzylaminopurine (BA: 0.5 ~ 2.0 mg/L) plus auxin α-naphthaleneacetic acid (NAA: 0.5 mg/L) formed shoots either directly or indirectly during primary culture. And the dark treatment and 2,4-dichlorophenoxyacetic acid (2,4-D) were ineffective for shoot formation but beneficial for callus stimulation. Furthermore, we discovered a negative correlation between initiating cutting recovery and tissue culture inducting, implying that cultivars with low difficulty in cutting initiating were relatively difficult to tissue culture. Then, we developed a simple and efficient Heuchera rapid propagation protocol. That is, micropropagation through obtaining adventitious shoots directly from primary cultures, supplemented by cutting propagation. Our petiole explants system and leaf-cutting technique are expected to guide Heuchera's mass production.
The deep-plane facelift as a treatment modality for antiretroviral therapy induced cervicofacial lipodystrophy
Authors: Kustermans Lise , Genechten Maarten Van , de Casteele Elke Van , De Vos Wouter
Published: October 2022

PURPOSE
Highly Active Anti Retroviral Therapy (HAART) has become an effective treatment modality to reduce HIV-infection to an undetectable viral load. These antiretroviral agents may, however, cause severe morbidity by inducing the syndrome of lipodystrophy. In the head and neck region antiretroviral agents generate an obtuse heavy neck in combination with an accelerated pattern of midfacial atrophy and ptosis. Modifying the antiretroviral therapy produces only limited improvement, therefore warranting a surgical approach. An extreme case of HAART-induced facial lipodystrophy is presented together with literature review to support the need for an extended surgical intervention in these patients.
METHODS
An overview of literature concerning the lipodystrophy effects of HAART and potential treatment modalities is carried out. This is illustrated with a case study of a 55-year old woman who received HAART therapy for 24 years and was particularly unhappy with her appearance due to cervical fat accumulation. Surgical technique and clinical results in this patient by means of deep-plane cervico-facial rhytidectomy including liposuction, subplatysmal lipectomy and platysma-digastric suspension are discussed.
RESULTS
The surgical technique has resulted in an aesthetically pleasing and predictable result with a quick recovery in this patient suffering from HAART-induced lipodystrophy.
CONCLUSION
The technique of deep-plane cervico-facial rhytidectomy including liposuction, subplatysmal lipectomy and platysma-digastric suspension is a valuable treatment modality in this patient group suffering from HAART-induced facial lipodystrophy. However, longitudinal studies of multiple subjects is required to assess stability of the outcome.
Patterns of influence of different landslide boundaries and their spatial shapes on the uncertainty of landslide susceptibility prediction
Authors: Xing Yin , Huang Saipeng , Yue Jianping , Chen Yang , Xie Wei , Wang Peng , Xiang Yunfei , Peng Yiqun
Published: October 2022

Landslide boundaries and their spatial shapes are usually presented as irregular polygonal surfaces such as semicircles and bumps, but some landslide susceptibility modelling uses idealized landslide points or buffer circles as landslide boundaries, bringing the uncertainty to susceptibility modelling. To study the influence of different landslide boundaries on modelling uncertainty, 362 landslides and 11 environmental factors in Ruijin City were selected, and established landslide boundaries and their frequency ratio correlations with environmental factors based on landslide points (Point), buffer circles (Circle) and accurately decoded and drawn polygons (Polygon), respectively. Afterwards, Deep Belief Network (DBN) and Random Forest (RF) were selected to construct models such as Point, Circle, Polygon-based DBN and RF. Finally, the modelling uncertainty analysis was carried out using receiver operating characteristic (ROC) accuracy, the distribution pattern of the susceptibility index and its variability. The results indicate that: (1) Using landslide points or buffer circles as landslide boundaries will increase modelling uncertainty, while using accurate landslide polygon boundaries is more effective in ensuring modelling accuracy and reliability. (2) The uncertainty pattern of landslide susceptibility modelling based on DBN and RF is the same, but the prediction accuracy of the RF model is lower than DBN, moreover, its uncertainty is higher than DBN. (3) The landslide susceptibility results obtained by using points and buffer circles as landslide boundaries can reflect the spatial distribution pattern of landslide probability in the study area as a whole and can use as an alternative solution in the absence of accurate landslide boundaries.
Deep learning model coupled with proteomics to detect yeast epidemic clones across multiple hospitals
Authors: Mohammad Noshine , Normand Anne Cécile , Nabet Cécile , Brossas Jean-Yves , Blaize Marion , Bonnal Christine , Fekkar Arnaud , Imbert Sébastien , Piarroux Renaud , Tannier Xavier
Published: October 2022

The ongoing worldwide emergence of epidemic azole-resistant Candida parapsilosis clones is a threat to human health. In order to monitor a clonal outbreak which involved 2 hospitals in Paris, we used a technology that most clinical laboratories are equipped with: Matrix-Assisted Laser Desorption-Ionization Time of Flight mass spectrometry (MALDI-TOF MS). This physico-chemical analysis technique was combined with machine learning algorithm to evaluate the possibility of monitoring a multi-center epidemic. A total of 96 isolates of Candida parapsilosis constituted of resistant clones, susceptible clones and other susceptible isolates were cultured on various culture conditions. Spectra were acquired on four different mass spectrometers from three hospitals. We used convolutional neural networks (CNN) to classify the isolates and identified the main parameters that can influence the identification of epidemic clonal isolates. We have shown results up to 94% accuracy in a multi-center context, and between 81 and 91% accuracy when the tested site is not part of the training set, showing that it is possible to differentiate the spectra of a clone and a non-clone presenting a very strong similarity. This study shows that it is possible to monitor a certain type of clone, namely the R2 clones in our case study, using MALDI-TOF coupled to CNN. The experimental conditions that impacted the results should be considered for future work to improve performances for difficult classification tasks like clonal fungal identification.
Synchrony to a beat predicts synchrony with other minds
Authors: Wohltjen Sophie , Toth Brigitta , Boncz Adam , Wheatley Thalia
Published: October 2022

Synchrony has been used to describe simple beat entrainment as well as correlated mental processes between people, leading some to question whether the term conflates distinct phenomena. Here we ask whether simple synchrony (beat entrainment) predicts more complex shared attentional states, consistent with a common mechanism. While eye-tracked, participants listened to regularly spaced tones and indicated changes in volume. Across multiple sessions, we found a reliable individual difference: some people entrained their attention more than others, as reflected in beat-matched pupil dilations that predicted performance. In a second study, eye-tracked participants completed the beat task and then listened to an eye-tracked storyteller. An individual’s tendency to entrain to a beat predicted how strongly their pupils synchronized with those of the storyteller, a measure of shared attention. The tendency to synchronize is a stable individual difference that predicts both beat entrainment and the coupling of minds, consistent with a common origin.
Correlation Between Mortality From Aortic Aneurysm, Sex, Administrative Regions and Age Group in Brazil
Authors: Santos Keller Da Silva , Galego Sidnei José , Lucena Diego Monteiro de Melo , Figueiredo Francisco Winter Dos Santos
Published: October 2022

Introduction Aneurysmal disease is a focal and permanent dilation of the vessel diameter greater than 50% of its normal diameter, whose natural history is the progressive enlargement of the aneurysm, culminating in its rupture, if not treated. Traditional risk factors are those common to other cardiovascular diseases. However, even though socioeconomic status has gained importance in terms of its influence on vascular diseases, few studies seek to understand the behavior of this disease in countries with high levels of socioeconomic inequality, such as Brazil. Objective to analyze the correlation between age group, sex, and mortality from aortic aneurysm in the Brazilian federative units. Method study with analysis of secondary data on mortality from Aortic Aneurysms in Brazilian states in the year 2019, extracted from the Global Burden of Disease platform and the Institute for Applied Economic Research. The program used for statistical analysis was Stata® (StataCorp, LC) version 11.0. Results Higher mortality was observed in males, with a statistically significant increase in mortality in age groups from 40 years onwards. There are also important regional differences in mortality from standardized Aortic Aneurysms in Brazilian administrative regions. Conclusion mortality from aortic aneurysm increases with age, with deaths being detected from the fourth decade of life onwards, although screening only occurs after 65 years of age. Such results may justify the need to include younger individuals, around 40 years of age, in the screening for aneurysm detection.
Influence of graft thickness on tunnel technique procedures for root coverage: A pilot split-mouth randomized controlled trial
Authors: Teodoro Victor Aguirre , Mattedi Marco Antonio Marques , Vergara-Buenaventura Andrea , Muniz Francisco Wilker Mustafa Gomes , Meza-Mauricio Jonathan , Faveri Marcelo , Ciotti Danilo Lazzari
Published: October 2022

Objective:To compare the clinical outcomes of the tunnel technique (TUN) combined with either thin connective tissue graft (C.T.G.) (TUN + thin C.T.G.) (1 mm) or thick C.T.G. (TUN + thick C.T.G.) (2 mm) for the treatment of localized gingival recession (G.R.).Material and methods:Twelve patients, with 24 maxillary localized type RT1 GR were randomly assigned into two groups. Clinical, esthetic, and patient‐reported outcomes were evaluated at baseline and at 6-month follow-up.Results: The TUN+thin C.T.G. group showed a higher mean G.R. reduction (1.53± 0.66) (primary outcome variable) than the TUN+thick C.T.G. group (1.44± 0.89), but no statistically significant difference was detected at the 6-month follow-up (p=0.77). No statistically significant differences were found between TUN+thin C.T.G. and TUN+thick C.T.G. concerning complete root coverage (C.R.C.) (58.3% versus 41.7%, respectively), gingival ticknness (G.T.) or Root-coverage Esthetic Score (R.E.S.) at 6 months. Regarding patient‐reported outcomes, both groups reported having experienced similar pain at 7 days (p>0.05). No statistically significant differences were found between the groups in the analysis of the aesthetic score.Conclusion:Both treatments showed a similar reduction in G.R. In addition, similar C.R.C., G.T., R.E.S., pain and self-reported esthetics were achieved in both groups.Clinical relevance:Application of thin CTG provided a similar result than thick CTG for the treatment of RT1 localized GR.
TM4SF1 Upregulates MYH9 to Activate the NOTCH Pathway to Promote Cancer Stemness and Lenvatinib Resistance in HCC
Authors: Yang Si-bo , Lei Jin , Zhou Zi-han , Li Xiao-wen , Chen Qian , Li Bo , Zhang Ye-wei , Ge Yu-zhen , Zuo Shi
Published: October 2022

TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recognized in recent years. Although some achievements have been made in the study of TM4SF1, the effect of TM4SF1 on cancer stemness in hepatocellular carcinoma (HCC) and its molecular basis are yet to be reported. We found through abundant in vitro and in vivo experiments which the expression of TM4SF1 was positively correlated with the progression and cancer stemness of HCC. We identified the downstream protein MYH9 of TM4SF1 and its final regulatory target NOTCH pathway using bioinformatics analysis and protein mass spectrometry. We cultivated a lenvatinib-resistant strain from HCC cells to examine the relationship between cancer stemness and tumor drug resistance. The study confirmed that TM4SF1 could regulate the NOTCH pathway by upregulating MYH9, thus promoting cancer stemness and lenvatinib resistance in HCC. This study not only provided a new idea for the pathogenesis of HCC but also confirmed that TM4SF1 might become a new intervention point to improve the clinical efficacy of lenvatinib in treating HCC.
Effect of Surgical Microscope and Illuminated Chopper on Anterior Chamber Temperature
Authors: Eom Youngsub , Lee Young Joo , Song Jong Suk , Kim Hyo Myung , Nam Dong Heun
Published: October 2022

Background

To evaluate the effect of the light intensity of the surgical microscope and illuminated chopper on the anterior chamber temperature.

Study Design

Experimental study.

Methods

A model eye (Kitaro WetLab System; FCI Ophthalmics, Pembroke, MA, USA) was used in this experimental study. The illuminance of a surgical microscope (Leica M300; Leica Microsystems, Wetzlar, Germany) and illuminated chopper (iChopper NAM-25GB; Oculight, Korea) with a light source (iVision; Oculight) was measured using an illuminometer. In addition, the temperature in the anterior chamber of the model eye filled with balanced salt solution when using the surgical microscope with a light intensity from level 1 to level 6 and the illuminated chopper at 99% light intensity was measured for 10 min.

Results

The anterior chamber temperature was increased by 0.2, 0.5, 1.0, and 1.4 ℃ when using the surgical microscope at level 3 (10050 lux), 4 (16490 lux), 5 (24900 lux), and 6 (32500 lux), respectively, for 10 min. The illuminated chopper at 99% light intensity (14893 lux) positioned in the anterior chamber increased the anterior chamber temperature by 0.2° C, which was equal to the increase in the temperature caused by the surgical microscope at level 3.

Conclusion

The photothermal effect of the illuminated chopper directly positioned in the anterior chamber appeared to be similar to that of a microscope with similar illuminance. Therefore, the illuminated chopper may be safely used in cataract surgery.
The effects of spin-orbit coupling on optical properties of monolayer MoS2 due to mechanical strains
Authors: rezania hamed , abdi mona , nourian erfan , astinchap bandar
Published: October 2022

We have studied the optical conductivity of a quasi two-dimensional MoS2 in the presence of external magnetic field and spin-orbit coupling. Specially, we address the frequency dependence of optical conductivity due to spin-orbit interaction. Using linear response theory the behavior of optical conductivity has been obtained within Green's function method. We have also considered the effects of uniaxial and biaxial in-plane strain on the optical absorption of MoS2 layer. In the absence of external magnetic field with negative uniaxial strain parameter, optical conductivity includes Drude weight at zero frequency limit while Drude weight vanishes for MoS2 layer under positive uniaxial strain. Our results show that the increase of uniaxial positive strain parameter causes to move the position peak to the higher frequencies. In contrast to uniaxial strain case, the Drude weight in optical conductivity appears at positive biaxial strain value ε=0.15. Also we have studied the effects of magnetic field, electron doping, hole doping in the presence of spin-orbit coupling on frequency dependence of optical conductivity of MoS2 in details. The magnetic field dependence of optical absorption shows a monotonic decreasing behavior for each value of temperature in the absence of strain parameter.
PACS numbers: 75.10.Jm, 75.30.Mb, 75.30.Kz, 75.40.Mg
Biomacromolecule supported N-heterocyclic carbene-palladium(II) as a novel catalyst for Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions
Authors: Antony Arnet , Chamanmalik Masira , Kandathil Vishal , Sampatkumar Harini , Sasidhar B. S. , Yelamaggad C. V. , Patil Siddappa
Published: October 2022

The field of catalysis is ever flourishing to meet the challenges faced in our day-to-day needs keeping in mind the environmental concerns. In line with this quest, a new N-heterocyclic carbene-palladium(II) complex grafted on cellulose, a naturally available biomacromolecule from agriculture waste sugarcane bagasse (Cellu@NHC-Pd) was synthesized as a heterogeneous catalyst. The facile multistep synthesis was achieved using low-cost chemicals and mild reaction conditions. The characterization of the Cellu@NHC-Pd heterogeneous catalyst by various analytical techniques such as FT-IR, FE-SEM, EDS, HR-TEM, TG/DTA, ICP-OES and p-XRD confirmed its structure, morphology, thermal stability and chemical composition. The Cellu@NHC-Pd heterogeneous catalyst was successfully investigated for its catalytic ability in Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions under green reaction medium at ambient temperature. The heterogeneous catalyst was examined for its catalytic effectiveness in the cross-coupling reactions for various parameters like solvent, base, temperature, time and catalyst loading. Additionally, the developed heterogeneous catalyst showed very good tolerance to a variety of functional groups. Being heterogeneous, the catalyst could be easily recovered by simple filtration. The Cellu@NHC-Pd heterogeneous catalyst can be additionally probed for its catalytic excellence in other applications.
Precoding-based Complex Field Network Coding Strategy for Multi-Source UAV Cooperative System
Authors: Zhao Mingfei , Xue Rui , Jiang Hang
Published: October 2022

Employing multiple UAVs as a swarm for investigation and surveillance can complete more complex missions. Since novel sensors equipped, vast amounts of data are continually generated as the increasing number of UAVs. Therefore, the process of multi-source data and the valuable information from the multi-source data is of significant importance. These data formats vary from traditional data to dynamic data with the characteristic of multi-source. Considering that vast amounts of multi-source data from UAV swarm require higher throughput performance of transmission schemes, complex field network coding (CFNC) is selected for UAV cooperative system. However, adverse effects like inter-user interference of fading channels will limit the reliability performance of UAV cooperative system. To improve the reliability performance and recover more accurate valuable information, we propose a precoding-based CFNC strategy for multi-source UAV cooperative system. The proposed transmission scheme processes data through precoding matrix, which is obtained by the transformation of channel state matrix. Compared to conventional CFNC schemes, precoding-based CFNC scheme improves the accuracy of detections. Through theoretical analysis and experimental results, the precoding-based CFNC transmission scheme not only maintains high throughput, but also recover more valuable information and achieves better reliability performance.
Clinical and pathological characterization of 158 consecutive and unselected oligometastatic breast cancers in a single institution
Authors: LACAZE Jean-Louis , Glemarec Gauthier , Chira Ciprian , Ung Mony , Massabeau Carole , Monselet Niels , Cassou-Mounat Thibaut , De Maio Eleonora , Jouve Eva , Perrière Clemence Brac de la , Selmes Gabrielle , Nicolai Vincent , Cabarrou Bastien , Dalenc Florence
Published: October 2022

Purpose: Data about incidence, biological and clinical characteristics of oligometastatic breast cancer (OMBC) are scarce. However, these data are essential in determining optimal treatment strategy. Gaining knowledge of these elements means observing and describing large, recent, and consecutive series of OMBC in their natural history.
Methods: We collected data retrospectively at our institution from 998 consecutive patients diagnosed and treated with synchronous or metachronous metastatic breast cancer (MBC) between January 2014 and December 2018. The only criterion used to define OMBC was the presence of one to five metastases at diagnosis.
Results: Of 998 MBC, 15.8% were classified OMBC. Among these, 88% had one to three metastases, and 86.7% had only one organ involved. Bone metastases were present in 52.5% of cases, 20.9% had progression to lymph nodes, 14.6% to the liver, 13.3% to the brain, 8.2% to the lungs, and 3.8% had other metastases. 55.7% had HR+/HER2- OMBC, 25.3% had HER2+ OMBC, and 19% HR-/HER2- OMBC. The HR+/HER2- subtype statistically correlated with bone metastases (p=0.001), the HER2+ subtype with brain lesions (p=0.001), and the HR-/HER2- subtype with lymph node metastases (p=0.008). Visceral metastases were not statistically associated with any OMBC subtypes (p=0.186). OMBC-SBR grade III was proportionally higher than in the ESME series of 22,109 MBC (49.4% vs. 35.2%, p< 0.001).
Conclusion: OMBC is a heterogeneous entity whose incidence is higher than has commonly been published. Not an indolent disease, each subgroup, with its biological and anatomical characteristics, merits specific management.
Proximalizing climate change to farmers: Improving risk communications using the lens of psychological distance
Authors: Yazdanpanah Masoud , Zobeidi Tahereh , (Sanagorski) Laura A. Warner , Sieber Stefan , Löhr Katharina
Published: October 2022

This study uses Construct Level Theory (CLT) to investigate Iranian farmers' beliefs in climate change occurrence and their adaptive behaviors to reduce its impacts. In the framework of CLT, people who perceive themselves to be psychologically close (proximal) to events and objects are better able to make decisions about them, while people seeing themselves as psychologically distant (distal) are less able to do so. CLT is thus a useful lens for examining the role of psychological distance in Iranian farmers' willingness to perform climate change adaptation behaviors. The current study aims to explore the relation between the four core dimensions of psychological distance—geographical/spatial; social; temporal; and hypothetical/uncertain—and their influence on farmers' beliefs, risk perceptions, and adaptation behavior relating to water management. This study contributes toward effective risk communication by agricultural extension and advisory services in Iran and beyond. The results of structural equation modeling confirm that all four dimensions of psychological distance impact water management adaptation strategies and non-farm activities. Moreover, all psychological dimensions, except the temporal dimension (i.e., the perceived time until the occurrence of climate change), affect adaptation in farming management. Thus, making climate change more proximal to decision makers could be a strategic way of encouraging individuals to take adaptive actions. This study emphasizes that concepts of psychological distance can be applied to help organizations (e.g. agriculture extension services) understand farmers’ risk perceptions and responses to climate change impacts and improve risk communication to better engage farmers in climate action.
Task Offloading Optimization Mechanism based on Deep Neural Network in Spatio-temporal Crowdsourcing
Authors: Meng Lingkang , Wang Yingjie , Wang Haipeng , Tong Xiangrong , Sun Zice , Cai Zhipeng
Published: October 2022

With the rise of edge computing technology and the development of intelligent mobile devices, task offloading in the edge cloud environment has become a research hotspot. Task offloading is also a key research issue in Mobile CrowdSourcing (MCS), where crowd workers collect sensed data through smart devices they carry and offload to edge servers or perform computing tasks locally. Current researches mainly focus on reducing resource consumption in edge servers, but fails to consider the conflict between resource consumption and service quality. Therefore, this paper considers the learning generation offloading strategy among multiple Deep Neural Network (DNN), proposed a Deep Neural Network-based Task Offloading Optimization (DTOO) algorithm to obtain an approximate optimal task offloading strategy to solve the conflict between resource consumption and service quality. In addition, a stack-based offloading strategy is researched. The resource sorting method allocates computing resources reasonably, thereby reducing the probability of task failure. Compared with the existing algorithms, the DTOO algorithm could balance the conflict between resource consumption and service quality in traditional MCS applications on the premise of ensuring a higher task completion rate.
Biomechanical effects of sacroiliac screw length and fixation segments in sacral fractures treated by triangular osteosynthesis
Authors: Ma Yupeng , Li Yu , Hong Huanyu , Huang Tao , Lin Jiangtao , Zhao Yong
Published: October 2022

[Objective] To examine the impact of altering the sacroiliac screw's position and length on the biomechanical properties of the triangle osteosynthesis used to treat unilateral vertical sacral fractures and serve as a clinical reference.
[Methods] Unilateral sacral fracture of type Denis II was modeled using finite elements to represent the Tile C pelvic ring damage. Fixation of sacral fractures using six triangular osteosynthesis patterns. To compare sacral stability, fracture separation values and maximum von Misses stress of internal fixation after fixation of sacral fractures by each internal fixation mode.
[Results] The best vertical stability occurs with lengthened sacroiliac screws for simultaneous fixation of S1S2 segments. Moreover, the fracture separation value was the smallest, the internal fixation stress distribution was uniform, and the maximum von Mills stress of internal fixation was the minimum.
[Conclusions] In unilateral vertical fracture of the sacrum (AO C3.1 DENISS II) treated with triangular osteosynthesis, S1-segment + S2-segment extended sacroiliac screw fixation results in optimal vertical sacral stability, fracture end stability, uniform internal fixation stress, and a lower risk of screw fracture. If only single-segment sacroiliac screws can be used, S1-segment extended sacroiliac screw fixation performs better.
DRD2 expression based on 18F-fallypride PET/MR predicts the dopamine agonist resistance of prolactinomas: A pilot study
Authors: Tang Hao , Cheng Yijun , Lou Xiaohui , Yao Hao , Xie Jing , Gu Weiting , Huang Xinyun , Liu Yanting , Lin Shaojian , Dai Yuting , Xue Li , Lin Xiaozhu , Wu Zhe Bao
Published: October 2022

Purpose
The dopamine agonists (DA) have been used widely to treat prolactinomas. However, it is difficult to predict whether the patient will be responsive to DA treatment.
Methods
We aimed to investigate whether the in vivo expression of DRD2 based on 18F-fallypride PET/MR could predict the therapeutic effect of DA on prolactinomas. Seven patients with prolactinomas who underwent surgery and further tumor immunohistochemistry completed 18F-fallypride PET/MR preoperatively. Imaging findings and immunohistochemical staining were compared with treatment outcomes.
Results
18F-fallypride PET/MR was visually positive in 7 of 7 patients, and DRD2 target specificity could be confirmed by immunohistochemical staining. A significantly lower tracer standard uptake value (SUV) could be detected in the resistant patients (n = 3) than in the sensitive patients (n = 4; SUVmean, 4.67 ± 1.32 vs. 13.57 ± 2.42, p < 0.05). DRD2 expression determined by 18F-fallypride PET/MR corresponded with the DA treatment response.
Conclusion
18F-fallypride PET/MR represents an effective diagnostic tool to predict DA response in patients with prolactinoma.