bluuebunny/crossref_metadata_2025 huggingface dataset:
Notch1 is asymmetrically distributed from the beginning of embryogenesis and controls the ventral center
Authors: Castro Colabianchi Aitana M. , Revinski Diego R. , Encinas Paula I. , Baez María Verónica , Monti Renato J. , Rodríguez Abinal Mateo , Kodjabachian Laurent , Franchini Lucía F. , López Silvia L.
Published: June 2018

Based on functional evidence, we have previously demonstrated that early ventral Notch1 activity restricts dorsoanterior development in Xenopus. We found that Notch1 has ventralizing properties and abolishes the dorsalizing activity of β-catenin by reducing its steady state levels, in a process that does not require β-catenin phosphorylation by glycogen synthase kinase 3β. In the present work, we demonstrate that Notch1 mRNA and protein are enriched in the ventral region from the beginning of embryogenesis in Xenopus. This is the earliest sign of ventral development, preceding the localized expression of wnt8a, bmp4 and Ventx genes in the ventral center and the dorsal accumulation of nuclear β-catenin. Knockdown experiments indicate that Notch1 is necessary for the normal expression of genes essential for ventral-posterior development. These results indicate that during early embryogenesis ventrally located Notch1 promotes the development of the ventral center. Together with our previous evidence, these results suggest that ventral enrichment of Notch1 underlies the process by which Notch1 participates in restricting nuclear accumulation of β-catenin to the dorsal side.
Drainage network characteristics of Athens plain at the end of the 19th century
Authors: Alexouli - Livaditi A. , Vouvalidis K. , Livaditis G. , Pechlivanidou S.
Published: June 2018

Kephissos River is the main fluvial system of the hydrological basin of Athens. It drains the central part of Attica and almost the entire urban area of the city of Athens. In this paper, we present the results of both the qualitative and quantitative analysis of the initial drainage network of the plain before the urbanization through the processing of digitised data with GIS software. The initial drainage network of the. basin, plotted with the use of a very detailed mosaic of maps, was constructed by German cartographers (Curtius E. and Kaupert J.) at the end of the 19' century. For the analysis of the drainage network the Laws of drainage composition were used and values for the D and F indices were calculated. One of the major aspects of this article is \o reveal information about the fluvial and environmental conditions in the plain of Athens before the urbanization of the area. This kind of information is very critical because until that time (end of the 19th century) the fluvial system of Kephissos\ was natural, without any human intervention.
Geomorphological reconnaissance of the Psathopyrgos and Rion-Patras Fault zones (Achaia, NW Peloponnesus).
Authors: Palyvos N. , Pantosti D. , Stamatopoulos L. , De Martini P. M.
Published: June 2018

In this communication we discuss reconnaissance geomorphological observations along the active Psathopyrgos and Rion-Patras (NE part) fault zones. These fault zones correspond to more or less complex rangefronts, the geomorphic characteristics of which provide hints on the details of the fault zone geometries, adding to the existing geological data in the bibliography. Aiming at the identification of locations suitable or potentially suitable for geomorphological and geological studies for the determination of fault slip rates in the Holocene, we describe cases of faulted Holocene landforms and associated surficial deposits. We also discuss problems involved in finding locations suitable for geological (paleoseismological) studies for the determination of the timing of recent earthquake ruptures, problems due to both man-made and natural causes.
Influence of the geometric characteristics of wedges on the safety of Vrasna tunnel in Egnatia highway, N. Greece
Authors: Chatziangelou M. , Christaras B.
Published: June 2018

The present paper concerns the influence of the geometric characteristics of the potential wedges on tunnels safety, which are supported by shotcrete and rock bolts, during the excavation of poor and medium quality rock mass, in accordance to RMR classification system. The geological and tectonic data which were used in our estimations were collected in situ during the excavation of Vrasna's tunnel. According to shear test along discontinuities planes, friction angle was considered 21° on schistosity planes and 35° on joint planes. Furthermore, no cohesion was taken into account, as the fractures were, more or less, opened. The orientation and spacing of discontinuities were taken into account for estimating tunnel stability, given that they affect the strength and the quality of the rock mass during the construction. The collected data and the obtained, after elaboration, results were correlated statistically and power regressions were determined
Study of northern Evia's ultramafic rocks as skid-resistant aggregates in pavement construction mountain (central Greece): correlations and evaluation
Authors: Kosiari S.
Published: June 2018

The study presented in this paper addresses the low skid-resistance factors measure d throughout the Hellenic road network. These low factors are mainly traced to the use of limestone as aggregate resource. The study is mainly focused on the capabili ty ofperidotite ofPapades region (N.Evia), to be used as aggregate resource since this rock is harder and thus more skid-resistant. Mechanical, petrographical and m ineralogical tests have been conducted in order to determine its suitability for skidresistant aggregates in pavement construction, according to Greek and Internation al standards and specifications.
Preservation of villages constructed on sliding areas - a case study from Karditsa Prefecture, Greece
Authors: Loupasakis C. , Karfakis J.
Published: June 2018

The mountainous areas of the Greek dominion are occupied by many occasionally inhabitable villages that were deserted because of the fact that they were founded on areas affected by landslides. Many of those villages, during the last years, were reconstructed and their houses were turned into occasionally inhabitable country houses. The proposed support and protection measures for the reconstruction of those villages must follow the rules of the rational management of the financial sources. The construction of expensive retaining structures in order to protect deserted houses or building sites of insignificant value is inexcusable. In those cases the geological studies must precede all reconstruction activities. Those studies can provide detailed guide-lines in order to prevent the reactivation of the landslides and/or to reduce the implications in case of reactivation. Also, the geological studies can determine the necessary combination of the protection and support measures capable to block the preparatory and the triggering causal factors of the sliding movements. This way, the cost of the applied measures reduces to acceptable levels, compatible to the occasional use of those villages. Petroxori village (Argithea district, Karditsa prefecture) is a typical example of a village constructed on an unstable area that generated several geotechnical problems. The evaluation of those problems and the presentation of the proposed measures can be a useful reference for the confrontation of similar situations
Rainfall and landslides in Karditsa county (Greece): a statistical approach
Authors: Pyrgiotis L. , Koukis G. , Sabatakakis N.
Published: June 2018

The mountainous area of Karditsa County, being geologically a representative sample of Olonos- Pindos geotectonic zone, is characterized by rainfall- induced landslides on steep slopes of high relief. After a systematic data inventory concerning landslides and their quantitative expression, the correlation between landslide occurrence and rainfall is investigated. Following the analyses performed a close interrelation between landslides and precipitation is established. Finally, a characteristic example of rainfall- induced landslide in the wider area of the county is given
National Park of Iti: Environmental and geomorphological impacts from the mining activity (Greece)
Authors: Mertzanis A. , Karetsos G. , Smyrni V. , Efthimiou G. , Zakinthinos G.
Published: June 2018

Bauxite excavation and the inert material quarries, in the wider region of the "National Park of Iti" in combination with the forest fires, the illegal logging, the grazing and the uncontrollable waste disposal, constituted the most important pressures in it's natural ecosystems. Particularly, bauxite ore exploitation that presented elation during the decade of '70s, was implemented without planning and it caused alterations in the natural environment of the region mainly by the continuous excavations, the foreheads of galleries and the extensive depositions of aggregates materials. As a result, all the above led to the occupation or the deforestation of forests and woodlands, the interruption of natural relief continuity and the change of natural géomorphologie processes. The aim of this work, concerns the determination of the impacts to the environment and more specifically the geomorphes and geomorphological processes, by the bauxite ore exploitation and the quarrying activity, that was developed in the wider region of the "National Park of Iti".
Remote sensing techniques in the search for ancient shipwrecks: how to distinguish a wreck from a rock in geophysical recordings
Authors: Sakellariou D.
Published: June 2018

This paper presents the way conventional marine geophysical methods may be used with the highest efficiency for deep-water archaeological research, especially for the detection of ancient shipwrecks. Their use becomes all the more effective, when the principles of oceanography and marine geology are being followed during the interpretation of the geophysical recordings. The integration of sub-bottom profiling data provides valuable information on the geological structure of the seafloor 's shallow substrate, which are an almost absolute prerequisite for a geologically reasonable interpretation of the side scan sonar images. Otherwise, interpretation of the sonar recordings may be erroneous or may be in direct discrepancy with the shallow sub-seafloor geological structure. Limitations of the efficiency of the geophysical methods in the case of targets of biogenic or anthropogenic origin or in shallow water environments are also being discussed
A contribution to environmental research of the Korissia coastal wetland (Corfu isl., Greece), with the application of combined geological and geophysical methods supported by Geographic Information Systems
Authors: Alexopoulos J. D. , Tomara V. , Vassilakis Em. , Papadopoulos T. D. , Dassenakis M. , Poulos S. , Voulgaris N. , Dilalos S. , Ghionis G. , Goumas G. , Pirlis E.
Published: June 2018

In the current paper are presented the results of a multidisciplinary study (stratigraphical, sedimentological, geophysical and geochemical) combined with modern techniques (G.I.S. and remote sensing). This study aims at integrating the natural and anthropogenic factors affecting the Korissia lagoon. It is a shallow coastal lagoon, communicating with the sea via an artificial channel. The area around the lagoon consists of alluvial sediments hosting, in places, newly formed and/or "old" (pre - Holocene) sand-dunes. The broader area constitutes a postalpine sedimentary basin characterised by smooth morphological relief. The lower stratigraphie unit of the post-alpine sequence is a Pleistocene marly formation, which was detected as the basement (5-15 Ohm.m) by the geophysical survey. The resistivity-based basement map implies the existence of a "palaeo-gulf" trending EW. These marls constitute the impermeable basement of a shallow aquifer hosted in the area. The salinity of the lagoon is very high during summer (>40psu) but it does not affect significantly the wells around it. The lagoon is well oxygenated, while the wells have lower D.O. values. Ammonia and nitrates are the main inorganic Nitrogen forms, in the lagoon and the wells, respectively. Phosphorus is the limiting factor for phytoplankton growth. Human activities affect the area that is in need of an environmental management plan in order to prevent ecological degradation
Vertical tectonic motion in Andaman Islands detected by multi-temporal satellite radar images
Authors: Parcharidis Is. , Foumelis M. , Lekkas E.
Published: June 2018

On 26 December 2004 one of the largest earthquakes ever recorded by modern seismology (Mw>9.0) occurred in Sumatra-Andaman region. About 1300km of seafloor were ruptured extending from northern Sumatra to Andaman Island complex. As instrumental data are sparse and in most of the cases field observations difficult to undertake, the role of remote sensing may be beneficial in providing information about the pattern of deformation in space and time. In the present study ENVISAT ASAR data are acquired and processed to generate a single multitemporal SAR image in order to detect vertical motion along Andaman Island. According to our analysis it seems that the northern parts of the island are generally uplifted. Though its north-western coasts show significant marL· of uplift, such indications become less evident along the western coasts of Middle Andaman. At some locations at the south-eastern margins of the island marks of downlift are recognized. Characteristic banding observed in the multi-temporal image could be attributed either to post-seismic relaxation, either to tidal phenomena. Although qualitative in nature, as just the sign of elevation change can be detected, results of such analysis could be used as constrains in deformation modelling research.
TMD symptoms and vertical mandibular symmetry in young adult orthodontic patients in North Sumatra, Indonesia: a cross-sectional study
Authors: Sofyanti Ervina , Boel Trelia , Soegiharto Benny , Auerkari Elza I.
Published: June 2018

Background: Temporomandibular joint disorder (TMD) includes symptoms of pain and dysfunction in the muscles of mastication and the temporomandibular joint. Differences in vertical condylar height, observed in the assessment of mandibular asymmetry, is a structural alteration that represents a risk factor for TMD. The study aimed to evaluate the association between TMD symptoms and vertical mandibular symmetry in young adult orthodontic patients in North Sumatra, Indonesia. 

Methods: The cross-sectional study included 18-25-year-old (mean ± SD, 21.9 ± 2.0 years) old orthodontic patients admitted to the Dental Hospital of Universitas Sumatera Utara, Medan, between June 2016 and March 2017. Vertical mandibular asymmetry was assessed from all 106 subjects using Kjellberg’s technique from pre-treatment panoramic radiographs. The TMD symptoms were assessed by structural interviews using modified questionnaires based on Temporomandibular Disorder Diagnostic Index and Fonseca’s Anamnestic Index.

Results: Of the 106 subjects, 26 (24.5% of the total) with vertical mandibular symmetry and 39 (36.8%) with vertical mandibular asymmetry were positive for TMD symptoms. By contrast, 17 patients (16.0% of the total) with vertical condylar symmetry and 24 patients (22.6%) with vertical mandibular asymmetry were regarded negative for TMD symptoms. There was no significant difference (p=0.520) in TMD symptoms based on vertical mandibular symmetry.

Conclusion: The results from this studied Sumatran population indicate that there are common TMD symptoms in young adult orthodontic patients, but there is no significant association between vertical mandibular asymmetry and TMD symptoms. Further study on the development of TMD, mandibular asymmetry and treatment planning for growing patients is suggested, using longitudinal and transitional approaches.
What does it mean if a patient is positive for anti-Jo-1 in routine hospital practice? A retrospective nested case-control study
Authors: Jobanputra Paresh , Malick Feryal , Derrett-Smith Emma , Plant Tim , Richter Alex
Published: June 2018

Background: It is widely believed that patients bearing auto-antibodies to histidyl tRNA synthetase (anti-Jo-1) very likely have a connective tissue disease including myositis and interstitial lung disease.  The value of positive tests in low disease prevalence settings such as those tested in routine care is unknown.  We sought to determine the value of anti-Jo-1 auto-antibodies in routine practice.

Methods: Our study was a nested case control study within a retrospective cohort of all patients tested for anti-ENA our hospital, from any hospital department, between January 2013 and December 2014.  Data was extracted from electronic records of anti-Jo-1 positive patients and randomly selected ENA negative patients (ratio of 1:2), allowing for a minimum follow up of at least 12 months after first testing.

Results:4009 samples (3581 patients) were tested.  Anti-ENA was positive in 616 (17.2%) patients, 40 (1.1%) were anti-Jo-1 positive. Repeat ENA testing was done for 350/3581 (9.8%) patients (428 of 4009 (10.7%) samples) and in 7/40 (17.5%) of anti-Jo-1 positive patients. The median interval between the first and second request was 124 days (inter-quartile range 233 days).  The frequencies of interstitial lung disease (ILD), myositis and Raynaud’s were comparable for anti-Jo-1 positive patients (n=40) and 80 randomly selected ENA negative controls.  Positive tests led to additional diagnostic testing in the absence of clinical disease.  Sensitivity of Jo-1 for ILD was 50% (CI 19-81%), specificity 68% (CI 59-77%), positive predictive value 12.5% (CI 4 to 27%) and negative predictive value 93.8% (CI 86-98%). Of 10 (25%) patients with high anti-Jo1 levels, 3 had ILD, one myositis and two a malignancy (disseminated melanoma and CML). 

Conclusion:Anti-Jo-1 is uncommon in a heterogenous hospital population and is only weakly predictive for ILD.  Repeated test requests were common and potentially unnecessary indicating that controls over repeat requests could yield significant cost savings.
The Study of Some Issues on the USA Migrational Politics (on the Basis of Linguistic Analysis of Presidents’ Addresses to the Nation)
Authors: Наталья Ростиславовна , Natal'ya Rostislavovna
Published: June 2018

The article describes metaphorical models which represent the concept of immigration in the discourse of ex US president Barack Obama and today’s American president Donald Trump. The conducted comparative analyses of remarks by two presidents in address to the nation on immigration distinguished certain metaphorical models which actualize different priority tendencies of immigrational politics of the presidents, and which serve for forming needed images and defining people’s way of thinking and behavior. The analysis showed how linguacultural images of American world view have changed during the last three years. The paper points out dominant metaphorical models characterizing immigration from different points of view. For Barack Obama immigration is a source of entrepreneurial and economic potential. Donald Trump’s metaphors present immigrants as aliens threatening the safety of the nation.
Unity of Verbal and Nonverbal Composition in Creolized Mediatex
Authors: Ленкова Т. , Lenkova T.
Published: June 2018

The article is devoted to the analysis of the compositional form in the creolized media text on the material of the modern supra-regional press of Germany. The paper deals with the connection between the verbal and nonverbal parts of the creolized media text at the composition level. Along with the traditional composition-linguistic form (CLF), it is proposed to allocate for the first time a composition-visual form (CVF), which is characteristic for creolized media texts as an informational-thematic unity of verbal and visual. In the proposed study, not only the new concept of composition-visual form is proposed, but also the distinction between the concepts of composition-linguistic visual form and composition-speech visual form based on the language-speech dichotomy.The linguistic phenomenon of the “composition-linguistic form” and the notion of “composition-visual form”, which is characteristic of medialinguistics as an interdisciplinary sphere of knowledge, should be viewed as a single whole, mutually encouraging each other, and influencing the perception of the contents of the creolized media text.
Discrete-Time System Optimal Dynamic Traffic Assignment (SO-DTA) with Partial Control for Physical Queuing Networks
Authors: Samaranayake Samitha , Krichene Walid , Reilly Jack , Monache Maria Laura Delle , Goatin Paola , Bayen Alexandre
Published: June 2018

We consider the System Optimal Dynamic Traffic Assignment (SO-DTA) problem with Partial Control for general networks with physical queuing. Our goal is to optimally control any subset of the networks agents to minimize the total congestion of all agents in the network. We adopt a flow dynamics model that is a Godunov discretization of the Lighthill–Williams–Richards partial differential equation with a triangular flux function and a corresponding multicommodity junction solver. The partial control formulation generalizes the SO-DTA problem to consider cases where only a fraction of the total flow can be controlled, as may arise in the context of certain incentive schemes. This leads to a nonconvex multicommodity optimization problem. We define a multicommodity junction model that only requires full Lagrangian paths for the controllable agents, and aggregate turn ratios for the noncontrollable (selfish) agents. We show how the resulting finite horizon nonlinear optimal control problem can be efficiently solved using the discrete adjoint method, leading to gradient computations that are linear in the size of the state space and the controls.

The online appendix is available at https://doi.org/10.1287/trsc.2017.0800 .
Epistemologia da prática e desenvolvimento profissional no Mestrado Profissional em Letras
Authors: Santos Marcos Bispo dos
Published: June 2018

O Programa de Mestrado Profissional em Letras (Profletras) teve início no ano de 2013 como resultado do esforço de expansão dos mestrados profissionais, modalidade de pós-graduação já prevista para oferta no Brasil desde 1965, conforme consta do Parecer nº 977/65 do Conselho Federal de Educação. Neste texto, questiona-se a adequação da pesquisa aplicada baseada na transposição de teorias para promover o desenvolvimento profissional dos docentes, de acordo com os objetivos do Programa. Partindo da proposta de formação profissional fundada na epistemologia da prática elaborada por Schön (2000) e desenvolvida por diversos outros autores como García (1999), Perrenoud (2008), Paquay et al. (2012), Tardif (2011) dentre outros, apresenta um modelo de formação profissional do professor reflexivo, entendido como mais coerente com os objetivos do Programa.
A reflexão no estágio de docência em língua inglesa: contribuições de uma instrução ao sósia
Authors: Modolo Soelene De Fátima Brovoski , Denardi Didiê Ana Ceni , Muniz-Oliveira Siderlene
Published: June 2018

Este artigo discute o papel da reflexão no estágio curricular supervisionado em um curso de Licenciatura em Letras – Português/Inglês de uma universidade pública localizada no sudoeste do Paraná, tendo por objetivo identificar a incidência de reflexão crítica de um aluno/professor, a partir do nível semântico do quadro de análise de textos do Interacionismo Sociodiscursivo (BRONCKART, 2012). Embasamo-nos em pressupostos teórico-metodológicos do Interacionismo Sociodiscursivo (BRONCKART, 2012), bem como nos pressupostos das disciplinas do trabalho, como a Ergonomia da Atividade e Psicologia do Trabalho, mais especificamente a Clínica da Atividade (CLOT, 2007, 2010). Abordamos uma concepção de estágio como pesquisa (PIMENTA, 1997; PIMENTA; LIMA, 2005/2006) e uma perspectiva reflexiva de formação (KEMMIS, 1985, ZEICHNER, 2008, CELANI, 2008, 2009; ZEICHNER; LISTON, 2014). Como resultados principais, identificamos figuras de agir que expressam uma reflexão crítica, vinculada a questões mais amplas sobre a educação, pois denotam a consciência do sujeito referente a implicações econômicas, políticas e sociais sobre a atividade de ensinar. Concluímos que o estágio supervisionado é um espaço propiciador de reflexão, que pode ser subsidiado por instrumentos, como a instrução ao sósia, utilizada nesta pesquisa, que pode contribuir para amenizar a falsa distância entre teoria e prática.
Interview with Dick Allwright
Authors: Allwright Dick , Miller Inés Kayon de , Bezerra Isabel C. R. Moraes
Published: June 2018

Interview granted to Inés Miller and Isabel C. R. Moraes Bezerra.
The number of treatment options for female intimate health issues is increasing
Authors: Fazzi Rosalind
Published: June 2018

Although sexual dysfunction and post-menopausal symptoms were issues that were previously overlooked, many women are now confiding in the health professionals they present to about their experiences of these common problems. Rosalind Fazzi summarises the main conditions women are facing and explores the expanding pool of surgical interventions and non-surgical procedures available for
Five years after Keogh's review of regulation in the aesthetics sector, what has changed?
Authors: Withey Simon , Mercer Nigel , Woollard Alex
Published: June 2018

A Government-commissioned review of the regulation of cosmetic interventions made many recommendations with a view to improve both standards of care and patient safety. In 2018, 5 years on from the review's publication, some progress has been made, but there is still much to be done. Simon Withey, Nigel Mercer and Alex Woollard reflect on key developments in the aesthetics sector
Identifying your brand principles to enable delegation of decision-making
Authors: Ratcliffe Jason
Published: June 2018

As a business owner, the decisions you make have a long-term impact on your brand, in addition to resolving the immediate problem. However, it is not always possible for business owners to make every decision themselves. Jason Ratcliffe discusses why having a set of principles for your brand is essential if you are to delegate decision-making responsibilities to your staff
Use of social media in the workplace: take-home messages from cautionary tales
Authors: Stevens Mark
Published: June 2018

Social media can be a boon for clinics wishing to promote themselves, but a curse should it be abused by an employee, maliciously or otherwise. Clinics which ignore potential issues in this area risk serious commercial damage. Mark Stevens outlines what employers need to know, what actions should be taken to manage a breach of company social media policy, and how to avoid employment tribunals
Chronic lymphocytic leukaemia: A guide for practice nurses
Authors: Perry Margaret Ann
Published: June 2018

Chronic lymphocytic leukaemia is the most common type of leukaemia. Margaret Ann Perry gives an overview of the condition and how practice nurses can support patients

This article is part three of a series on types of leukaemia and focuses on chronic lymphocytic leukaemia, the most common type of adult leukaemia in the Western world. The disease mainly affects older adults, and is often diagnosed incidentally when the patient has a blood test for something else. This article aims to increase knowledge and understanding of the disease presentation, diagnosis, and management, so that nurses will feel more confident in supporting patients and their families.
Management of incontinence associated dermatitis
Authors: Hoyle Joanne
Published: June 2018

Joanne Hoyle discusses how nurses can treat and manage dermatitis brought on by incontinence

Incontinence associated dermatitis is a type of contact dermatitis that occurs in individuals who have urinary and/or faecal incontinence, often causing significant discomfort, and reduced quality of life. The NHS estimates that between 3 and 6 million people in the UK have some degree of urinary incontinence. This article focuses on continence assessment, management and skin care to prevent and manage incontinence associated dermatitis.
RESEARCH ROUNDUP
Authors: Winter George
Published: June 2018

George Winter provides an overview of recently published articles that may be of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided
Advising those who travel to visit friends and relatives
Authors: Driver Carolyn
Published: June 2018

Those who visit friends and relatives make up nearly one-quarter of international travellers from industrialised countries. They suffer a disproportionate amount of vaccine-preventable and other travel-related illness and are less likely to attend for pre-travel advice than other travellers. Even if they do seek pre-travel advice, research shows that travellers visiting friends and relatives seem less inclined to follow recommendations for preventive strategies. This article looks at potential barriers and strategies for advising this vulnerable group of travellers in primary care.
When theatre meets fandom: Audience reviews of Harry Potter and the Cursed Child
Authors: Sedgman Kirsty
Published: June 2018

The 2016 launch of the stage production Harry Potter and the Cursed Child presented fans with their final opportunity – the first in nearly a decade – to reunite with the characters of their beloved series. Running in London’s West End since summer 2016 and transferring to Broadway in 2018, Cursed Child presents an unusual case study of what happens when an author working in other media chooses to continue their own storyworld onstage. This makes it the ideal focus point to explore what happens when theatre and fandom collide. The play script was also published in book format, and quickly became the fastest-selling theatre script since records began. But what did audiences themselves make of this dual rebirth? This article explores how the live performance and the playtext were received by fans as very different forms of afterlife. This has prompted important questions about access. Presented with an extension to their beloved storyworld after so many years, what happens when Harry Potter fans found themselves unable to actually take part in this new theatrical experience? And to what extent was the publication of the script a fair compromise in return for audiences’ undying loyalty? This article analyses both the specific example of Cursed Child and offers a more general exploration of fan-led efforts to democratize access to exclusive live events.
The forensics of the pavement
Authors: Edwards Harriet
Published: June 2018

This text represents a small experiment in writing. It is centred on an urban Hackney patch outside the flat where I stay in Stoke Newington, north London. It attempts to take in some dynamics of past and present, the composition of the pavement and some history above and below it. Hackney itself was once an orchard retreat for plague victims, but this patch is now territory of tarmac, pollution, foxes, shoppers, gulls, cyclists, a shooting, a mugging and a boy hidden in a bin. But it is a community, a functioning one, full of life. Influences on this episodic approach come from George Perec, with his invitations to transcribe the city; Henri Lefebvre’s Rhythmanalysis, with his theory of the city based on rhythm, and Tim Ingold’s ‘anthropology’ of line, capturing the traces and threads that compose and surround our lives.
Fenomena Post Democracy Party di Indonesia: Kajian Atas Latar Belakang, Karakteristik dan Dampaknya
Authors: Noor Firman
Published: June 2018

Abstrak Di era demokrasi saat ini beberapa partai di Indonesia nampak memiliki karakter unik dimana tidak tumbuh dari masyarakat dan bukan pula merupakan sebuah institusi yang awalnya adalah perantara antara anggota parlemen dengan masyarakat. Kehadiran partai berkarakter post-democracy itu sendiri ditengarai merupakan dampak dari kondisi kehidupan politik yang sudah bergeser dari bentuk demokrasi yang dianggap ideal. Dengan menggunakan pisau analisis dari Colin Crouch artikel ini membedah latar belakang dan karakter partai-partai di Indonesia saat ini, serta menguji sejauh mana partai-partai tersebut dapat disebut sebagai post-democracy. Pada bagian akhir artikel ini akan membahas berbagai potensi dampak yang ditimbulkan. Secara umum tulisan ini memperlihatkan bahwa saat ini beberapa partai-partai di Indonesia memang memiliki karakter partai post democracy. Namun secara umum karakter itu bukan merupakan sesuatu hal yang permanen mengingat cenderung berpotensi semakin luntur seiring dengan makin lamanya partai-partai itu berkecimpung dalam kehidupan politik riil.  Kata Kunci: Post-Democray, Partai, Politik, Oligarki, Regulasi, Alienasi
O Início da Epidemia do Zika Vírus e os seus Reflexos na Saúde Pública Nacional e Internacional
Authors: Petrônio Cícera Nerilda Vieira , Melo Antonio Marlos Duarte de , Mesquita Neto Edmar , Sampaio José Angelo Araújo , Telles Maria Valéria Leimig , Souza Conceição Maria Santos Correia de
Published: June 2018

No final do ano de 2015, observou-se um aumento exponencial no número de casos notificados de recém nascidos com microcefalia, definida pela medida do perímetro cefálico (PC) menor que dois desvios padrões em relação a média populacional, para dado sexo e idade gestacional, segundo a Organização Mundial de Saúde (OMS). Em consonância a isso, a infecção pelo Zika vírus (ZIKV), uma arbovirose emergente no país, tornou-se uma endemia. Este trabalho tem como objetivo estudar a associação da infecção intra-útero pelo Zika vírus e a ocorrência de microcefalia no período neonatal, apresentando os dados mais recentes referente à etiologia, epidemiologia e fisiopatologia da Síndrome do Zika vírus, além de descrever os desfechos relacionados a exposição ao ZIKV na gestação e avaliar o prognóstico das crianças afetadas pela microcefalia. Foi realizada uma revisão de literatura a partir de artigos científicos, livros e boletins epidemiológicos na elaboração do presente estudo. Assim, verificou-se que os portadores de microcefalia associada ao ZIKV apresentam atraso importante no desenvolvimento neuropsicomotor associado a alterações visuais, auditivas e sensoriais, o que irá impactar na independência funcional e na inserção social dos mesmos. Ainda são escassos os conhecimentos sobre essa síndrome, tanto sobre sua evolução natural, como dos seus fatores de risco ou associados, sendo necessários mais estudos sobre a temática. Palavras–chave: Vírus Zika, Gestação, Microcefalia.
Princípios de composição: descripções, narrações, cartas etc. por Guilherme do Prado (1895)
Authors: Inácio Filho Geraldo
Published: June 2018

Os manuais escolares são utilizados no Brasil, para uso de professores e alunos desde fins do século XIX e, no decorrer do século XX firmaram-se como objetos ou utensílios da cultura escolar. Este artigo analisa um manual escolar produzido no Brasil em 1895 – Princípios de Composição por Guilherme do Prado. A investigação centra-se nas prescrições para o ensino da redação/composição na escola e procura ressaltar como o autor assimilou conhecimentos que contribuíram para fazer da composição/redação um saber escolarizado.Palavras-chave: Manual escolar. Redação. Cultura escolar; História da Educação. AbstractSchool manuals to be used by teachers and students were established in Brazil in the late 19th century and were consolidated throughout the 20th century as objects or instruments of school culture. This article examines a school manual produced in Brazil at 1895 – Princípios de Composição, by Ghuilherme do Prado. This research focuses on the requirements for the teaching of writing at school and seeks to highlight how authors used knowledge that contributed to make writing a school knowledge.Keywords: School textbook. Writing. School culture. History of Education.ResumenLos manuales escolares han sido utilizados en Brasil para uso de profesores y alunos desde finales del siglo XIX y se consolidaron a lo largo del siglo XX como objetos ou instrumentos de la cultura escolar. Este articulo analiza un manual escolar produzido en Brasil nel año 1895 por Guilherme do Prado. La investigación se centra en las prescripciones para la enseñanza de la escritura y procura ressaltar como el autor ha integrado conocimientos que contribuyeron a hacer de la escritura un saber escolarizado.Palabras-clave: Manual escolar. Escritura. Cultura escolar. Historia de la Educación.
The development of technical and scientific professional education systems: an analysis through activity theory using Engeström’s historical type model/ O desenvolvimento dos sistemas de formação técnico-científica: uma análise pela teoria da atividade usando o modelo de tipos históricos de Engeström. (Bilingual Edition)
Authors: Campos Dilhermando Ferreira , Pinto Márcia Maria Fusaro
Published: June 2018

A necessidade de disseminar a formação técnico-científica advinda com o modo de produção moderno foi um fator influente no estabelecimento dos atuais sistemas de ensino. A partir de uma perspectiva mais utilitária dada à educação, responsável por muitas características do currículo e das práticas escolares, o modelo educacional foi se adequando às novas demandas e níveis de organização social. Para compreender melhor esse processo e seus conflitos internos, utilizaremos os conceitos da teoria da atividade, mais especificamente o modelo de tipos históricos elaborado por Y. Engeström para sistematizar a evolução de uma atividade ao longo da história.Palavras-chave: teoria da atividade. história da educação. formação técnico-científica. AbstractThe need to wider disseminate the technical and scientific education arising from the modern modes of production was an influential factor in the establishment of the current educational systems. Attributing to education a more utilitarian perspective, responsible for many features of the curriculum and school practices, the educational model has been adapted to the new demands and levels of social organization. In order to better understand this process as well as its internal conflicts, we will use notions of the activity theory, specifically the historical type model developed by Y. Engeström to systematize the evolution of an activity throughout of history.Keywords: Activity theory. History of Education. Technical and scientific professional education.ResumenLa necesidad de difundir la formación técnico-científica que surge con el modo de producción moderno, era un factor influyente en el establecimiento de los sistemas de enseñanzas actuales. Desde una perspectiva más utilitaria dada a la educación, responsable por muchas características del currículo y de las prácticas escolares, el modelo educativo se ha ido adaptando a las nuevas demandas y niveles de organización social. Para entender mejor este proceso y sus conflictos internos, utilizaremos los conceptos de la teoría de la actividad, más específicamente el modelo de tipos históricos elaborados por Y. Engeström para sistematizar la evolución de una actividad a lo largo de la historia.Palabras claves: Teoría de la actividad. Historia de la Educación. Formación técnico-científica.
Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery
Authors: van Egmond Maarten A. , van der Schaaf Marike , Hagens Eliza R. C. , van Laarhoven Hanneke W. M. , van Berge Henegouwen Mark I. , Haverkort Elizabeth B. , Engelbert Raoul H. H. , Gisbertz Suzanne S.
Published: June 2018

Background and Purpose:

Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperative recovery due to decreased muscle mass. Therefore, in this cross-sectional study, we aimed to investigate the association between muscle mass and muscle strength in predominantly older patients with esophageal cancer awaiting esophagectomy prior to neoadjuvant chemoradiation.

Methods:

In patients with resectable esophageal cancer eligible for surgery between March 2012 and October 2015, we used computed tomographic scans to assess muscle mass and compared them with muscle strength measures (handgrip strength, inspiratory and expiratory muscle strength, 30 seconds chair stands test). We calculated Pearson correlation coefficients and determined associations by multivariate linear regression analysis.

Results and Discussion:

A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, −0.91 to −0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R
2) in muscle surface area at L3 (P < .01).

Conclusions:

This study shows an independent association between aspects of muscle strength and muscle mass in patients with esophageal cancer awaiting surgery, and physiotherapists could use the results to predict muscle mass on the basis of muscle strength in preoperative patients with esophageal cancer.
Emotion Pictures: International Melodrama, a Virtual Report
Authors: Williams Linda
Published: June 2018

In the winter of 2017–18, the Film Society at Lincoln Center held a series, Emotion Pictures: International Melodrama, organized by Dennis Lim, Florence Almozine, and Tyler Wilson. The occasion of this series offered an irresistible opportunity to comment on this most elusive and chameleon-like of film categories and to consider its status today. Williams takes issue with much of the programming stating that, “This is not a plea to insert more logic into an emotional/sensational category that has none, but rather a plea to recognize how old-fashioned and anachronistic it is to still consider “classical cinema” the mainstream—and melodrama, its generic exception.”
Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology
Authors: Saucedo Lucía , Sobarzo Cristian , Brukman Nicolás G , Guidobaldi Héctor A , Lustig Livia , Giojalas Laura C , Buffone Mariano G , Vazquez-Levin Mónica H , Marín-Briggiler Clara
Published: June 2018

Fibroblast growth factor 2 (FGF2) and its receptors (FGFRs) have been described in several tissues, where they regulate cellular proliferation, differentiation, motility and apoptosis. Although FGF2/FGFRs expression in the male reproductive tract has been reported, there is scarce evidence on their presence in the female reproductive tract and their involvement in the modulation of sperm function. Therefore, the objective of this study was to determine the expression of FGF2 in the female reproductive tract and to assess the role of the FGF2/FGFRs system in the regulation of sperm physiology using the murine model. FGF2 was detected in uterus and oviduct protein extracts, and it was immunolocalized in epithelial cells of the uterus,isthmusandampulla, as well as in thecumulus oophorus-oocyte complex. The receptors FGFR1, FGFR2, FGFR3 and FGFR4 were immunodetected in the flagellum and acrosomal region of sperm recovered from thecaudaepididymis. Analysis of testis sections showed the expression of FGFRs in germ cells at different stages of the spermatogenesis, suggesting the testicular origin of the sperm FGFRs. Sperm incubation with recombinant FGF2 (rFGF2) led to increased sperm motility and velocity and to enhanced intracellular Ca2+levels and acrosomal loss compared to the control. In conclusion, this study shows that FGF2 is expressed in tissues of the female reproductive tract. Also, the fact that functional FGFRs are present in mouse sperm and that rFGF2 affects sperm motility and acrosomal exocytosis, suggests the involvement of this system in thein vivoregulation of sperm function.
Qualitative and quantitative differences between common occupational health risk assessment models in typical industries
Authors: Tian Fang , Zhang Meibian , Zhou Lifang , Zou Hua , Wang Aihong , Hao Mo
Published: June 2018

Objective

The differences in the methodologies of various occupational health risk assessment (OHRA) models have not been extensively reported. We aimed to understand the qualitative and quantitative differences between common OHRA models in typical industries.

Methods

The Environmental Protection Agency (EPA), Australian, Romanian, Singaporean, International Council on Mining and Metals (ICMM), and the Control of Substances Hazardous to Health (COSHH) models were evaluated, and a theoretical framework was established for a comparative study.

Results

Qualitative comparisons showed that each OHRA model had its own strengths and limitations, and exhibited a diverse distribution at different levels for each evaluation indicator. The Singaporean, COSHH, and EPA models had a much higher comprehensive advantage than the other models for all indicators. Quantitative comparisons demonstrated that these three models also had a stronger ability to distinguish the difference in risk ratios between different industries. The Singaporean model had the strongest correlation with the other models.

Conclusion

Each model possessed its own strengths and limitations depending on its unique methodological principles. Combining the EPA, Singaporean, and COSHH models might be advantageous for developing an OHRA strategy. More studies comparing multiple models in key industries are required.
Respiratory Viruses and Treatment Failure in Children With Asthma Exacerbation
Authors: Merckx Joanna , Ducharme Francine M. , Martineau Christine , Zemek Roger , Gravel Jocelyn , Chalut Dominic , Poonai Naveen , Quach Caroline ,   for the Pediatric Emergency Research Canada (PERC) DOORWAY team
Published: June 2018

OBJECTIVES:

Respiratory pathogens commonly trigger pediatric asthma exacerbations, but their impact on severity and treatment response remains unclear.

METHODS:

We performed a secondary analysis of the Determinants of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY) study, a prospective cohort study of children (aged 1–17 years) presenting to the emergency department with moderate or severe exacerbations. Nasopharyngeal specimens were analyzed by RT-PCR for 27 respiratory pathogens. We investigated the association between pathogens and both exacerbation severity (assessed with the Pediatric Respiratory Assessment Measure) and treatment failure (hospital admission, emergency department stay >8 hours, or relapse) of a standardized severity-specific treatment. Logistic multivariate regressions were used to estimate average marginal effects (absolute risks and risk differences [RD]).

RESULTS:

Of 958 participants, 61.7% were positive for ≥1 pathogen (rhinovirus was the most prevalent [29.4%]) and 16.9% experienced treatment failure. The presence of any pathogen was not associated with higher baseline severity but with a higher risk of treatment failure (20.7% vs 12.5%; RD = 8.2% [95% confidence interval: 3.3% to 13.1%]) compared to the absence of a pathogen. Nonrhinovirus pathogens were associated with an increased absolute risk (RD) of treatment failure by 13.1% (95% confidence interval: 6.4% to 19.8%), specifically, by 8.8% for respiratory syncytial virus, 24.9% for influenza, and 34.1% for parainfluenza.

CONCLUSIONS:

Although respiratory pathogens were not associated with higher severity on presentation, they were associated with increased treatment failure risk, particularly in the presence of respiratory syncytial virus, influenza, and parainfluenza. This supports influenza prevention in asthmatic children, consideration of pathogen identification on presentation, and exploration of treatment intensification for infected patients at higher risk of treatment failure.