bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrodynamic Performance of a Multi-Module Three-Cylinder Floating Breakwater System under the Influence of Reefs: A 3D Experimental Study
Authors: Guo Jianting , Zhang Yongbin , Bian Xiangqian , Xu Sheng
Published: December 2021

As the technical and theoretical research of floating breakwaters is becoming increasingly mature, the floating breakwaters are now being utilized, especially in offshore reefs. Therefore, it is of practical significance to study the hydrodynamic performance of a multi-module floating breakwater system under the influence of reefs. In this study, a 3D model experiment was carried out on a system consisting of eight three-cylinder floating breakwater modules under the influence of reefs. A wave attenuation mesh cage was incorporated at the bottom of the model. The floating breakwater system was slack-moored in its equilibrium position, and each module was connected by elastic connectors. The reefs were modeled on a bathymetric map of existing reefs in the East China Sea. In this experiment, the wave transmission coefficients, motion responses, and mooring forces of the floating breakwater system were measured. The results showed that the three-cylinder floating breakwater in the beam waves (β = 90°) has excellent wave attenuating performance under the influence of reefs, especially for short-period waves. However, under the influence of the reef reflection wave and the shallow water effect, the motion responses in the three main stress directions of the floating breakwater were large, and there was some surge and pitch motion. Under the influence of the aggregation and superposition of reflected waves on both sides of the reefs, the peak mooring forces in the middle position of the floating breakwater system were the largest at large wave height. The three-cylinder floating breakwater exhibited satisfactory hydrodynamic performance under the influence of reefs. It has broad application prospects in offshore reefs.
Whose Pictures, Whose Reality? Lines of Tradition in the Development of Topics, Negativity, and Power in the Photojournalistic Competition World Press Photo
Authors: Godulla Alexander , Seibert Daniel , Planer Rosanna
Published: December 2021

Initially founded in 1955 as a platform for Dutch photojournalists to increase international exposure, the World Press Photo competition has grown into the most prestigious contest of photojournalism worldwide, making it an important arena for journalism research. Using qualitative and quantitative content analyses, this study examines all photos shown in the competitions from 1960 to 2020 (N = 11,789) considering the origin of jury members (N = 686), participants (N = 132,800), placements (N = 2347) and the Human Development Index (HDI) of the countries. The topics displayed on the photos, their degree of negativity, and potential power structures in the photos are analysed over time both in terms of continental and HDI-related differences. Significant results show that Africa, Asia, and South America are more frequently depicted by the topic conflict and characterised by negative images than continents with industrialised nations (Australia/Oceania, Europe, North America). Participating European countries have a significantly higher average number of jury members, participants, and placements than participating countries from Africa, Asia, and South America, which seems to account for a dominant Eurocentric view. Implications and critical discussions are summarized in three interim conclusions at the end of this extended paper.
Diagnostic Accuracy of Computed Tomography for the Prediction of the Need for Laparotomy for Traumatic Hollow Viscus Injury: Systematic Review and Meta-Analysis
Authors: Hsia Cheng-Chieh , Wang Chen-Yu , Huang Jen-Fu , Hsu Chih-Po , Kuo Ling-Wei , Ouyang Chun-Hsiung , Liao Chien-Hung , Chen Huan-Wu
Published: December 2021

Background: Traumatic hollow viscus injury (THVI) is one of the most difficult challenges in the trauma setting. Computed tomography (CT) is the most common modality used to diagnose THVI; however, various performance outcomes of CT have been reported. We conducted a systematic review and meta-analysis to analyze how precise and reliable CT is as a tool for the assessment of THVI. Method: A systematic review and meta-analysis were conducted on studies on the use of CT to diagnose THVI. Publications were retrieved by performing structured searches in databases, review articles and major textbooks. For the statistical analysis, summary receiver operating characteristic (SROC) curves were constructed using hierarchical models. Results: Sixteen studies enrolling 12,514 patients were eligible for the final analysis. The summary sensitivity and specificity of CT for the diagnosis of THVI were 0.678 (95% CI: 0.501–0.809) and 0.969 (95% CI: 0.920–0.989), respectively. The summary false positive rate was 0.031 (95% CI 0.011–0.071). Conclusion: In this meta-analysis, we found that CT had indeterminate sensitivity and excellent specificity for the diagnosis of THVI.
Ownership Structure and Firm Performance in the Middle East: A Meta-Analysis
Authors: Al-Janadi Yaseen
Published: December 2021

This paper applies a meta-analysis method to investigate the moderating impact of political stability on the relationship between ownership identities and firm performance in the Middle Eastern countries (i.e., the Arab World). The study collected 105 correlations from 46 previous studies with 11,999 observations in 11 Middle Eastern countries. The findings show that most ownership identities such as institutional ownership, government ownership, inside ownership, and family ownership have positive relationship with firm performance. Another interesting finding shows that in countries with political instability, the level of ownership identities such as institutional ownership, foreign ownership, and inside ownership play an important role in controlling companies, which leads to firm performance. The meta-analysis results reveal that different levels of political stability have an impact on the role of the majority shareholders. The findings provide evidence that the performance of ownership identities in the Middle Eastern countries remains effective, especially with the existence of fair protection rights and political stability.
Sodium in Hemodialysis Fluid
Authors: Agarwal Sanjay Kumar
Published: December 2021

The principal aim of dialysis in relation to sodium is that dialysate sodium should not be low enough to cause intradialytic hypotension and cramps, and should not be high enough to cause interdialytic weight gain and hypertension. Dialysis sodium at 138 meq/L is supposed to be neutral and for most patients, this remains the standard sodium level for regular long-term dialysis. In my opinion, sodium should be changed temporarily from this level to 142 meq/L in selected patients only for a few dialysis sessions, where the cause of intradialytic hypotension is not obvious. In patients who regularly go into intradialytic hypotension and whose cause of intradialytic hypotension is unclear or cannot be corrected, sodium profiling should be used for maintenance dialysis. There is no consensus on the level of sodium, although I think 142 meq/L for the initial hour followed by a decrease to 138 meq/L in the last hour is sensible.
Opinion on the (Hemo)dialysate Sodium Prescription: Dialysate Sodium Prescription Should Not Be Considered in Isolation
Authors: Ng Khai Ping , Dasgupta Indranil
Published: December 2021

With advances in hemodialysis technology and the desire to achieve cardiovascular stability during dialysis, prescribed dialysate sodium concentration has gradually increased over the years. Short-term trials suggest low dialysate sodium (<138 mEq/L) is beneficial in reducing interdialytic weight gain, pre- and post-dialysis BP, and predialysis serum sodium; but it increases intradialytic hypotensive episodes. We believe dialysate sodium prescription cannot be considered in isolation. Our approach is to use patient symptoms, meticulous fluid volume management and low temperature dialysate in conjunction with neutral dialysate sodium in managing our dialysis patients. Long-term trials are needed to inform optimum dialysate sodium prescription.
Spatio-Temporal Patterns of Increasing Illegal Livestock Grazing over Three Decades at Moyowosi Kigosi Game Reserve, Tanzania
Authors: Musika Nyangabo V. , Wakibara James V. , Ndakidemi Patrick A. , Treydte Anna C.
Published: December 2021

The global increase of livestock has caused illegal intrusion of livestock into protected areas. Until now, hotspot areas of illegal grazing have rarely been mapped, long-term monitoring data are missing, and little is known about the drivers of illegal grazing. We localized hotspots of illegal grazing and identified factors that influenced spatio-temporal patterns of illegal grazing over three decades in the Moyowosi Kigosi Game Reserve (MKGR), Tanzania. We used questionnaires with local pastoralists (N = 159), georeferenced aerial survey data and ranger reports from 1990–2019 to understand the reasons for illegal grazing in the area. We found that hotspots of illegal grazing occurred initially within 0–20 km of the boundary (H (3) = 137, p < 0.001; (H (3) = 32, p < 0.001) and encroached further into the protected area with time (H (3) = 11.3, p = 0.010); (H (2) = 59.0, p < 0.001). Further, livestock herd sizes decreased with increasing distance from the boundary (R = −0.20, p = 0.020; R = −0.40, p = 0.010). Most interviewees (81%) claimed that they face challenges of reduced foraging land in the wet season, caused by increasing land used for cultivation, which drives them into the MKGR to feed their livestock. We conclude that there is spatio-temporal consistency in the illegal livestock intrusion over three decades, and hotspot areas are located along the boundary of the MKGR. We suggest focusing patrols at these hotspot areas, especially during the wet season, to use limited law enforcement resources effectively.
Analysis of the Quasi-Static and Dynamic Fracture of the Silica Refractory Using the Mesoscale Discrete Element Modelling
Authors: Grigoriev Aleksandr S. , Zabolotskiy Andrey V. , Shilko Evgeny V. , Dmitriev Andrey I. , Andreev Kirill
Published: December 2021

Computer modelling is a key tool in the optimisation and development of ceramic refractories utilised as insulation in high-temperature industrial furnaces and reactors. The paper is devoted to the mesoscale computer modelling of silica refractories using the method of homogeneously deformable discrete elements. Approaches to determine the local mechanical properties of the constituents from the global experimental failure parameters and respective crack trajectories are considered. Simulations of the uniaxial compressive and tensile failure in a wide range of quasi-static and dynamic loading rates (102 s−1) are performed. The upper limit of the dynamic loading rates corresponds to the most severe loading rates during the scrap loading on the refractory lining. The dependence of the strength, fracture energy, and brittleness at failure on the loading rate is analysed. The model illustrates that an increase in the loading rate is accompanied by a significant change in the mechanical response of the refractory, including a decrease in the brittleness at failure, a more dispersed failure process, and a higher fraction of the large grain failure. The variation of the grain–matrix interface’s strength has a higher impact on the static compressive than on the static tensile properties of the material, while the material’s dynamic tensile properties are more sensitive to the interface strength than the dynamic compressive properties.
On the Geometrical Properties of the Lightlike Rectifying Curves and the Centrodes
Authors: Sun Jianguo , Zhao Yanping , Jiang Xiaoyan
Published: December 2021

This paper mainly focuses on some notions of the lightlike rectifying curves and the centrodes in Minkowski 3-space. Some geometrical characteristics of the three types of lightlike curves are obtained. In addition, we obtain the conditions of the centrodes of the lightlike curves are the lightlike rectifying curves. Meanwhile, a detailed analysis between the N-type lightlike slant helices and the centrodes of lightlike curves is provided in this paper. We give the projections of the lightlike rectifying curves to the timelike planes.
Optimization of a High-Performance Poly(diallyl dimethylammonium chloride)-alumina-perfluorooctanoate Intercalated Ultrafiltration Membrane for Treating Emulsified Oily Wastewater via Response Surface Methodology Approach
Authors: Raji Yusuf Olabode , Othman Mohd Hafiz Dzarfan , Nordin Nik Abdul Hadi Sapiaa Md , Adam Mohd Ridhwan , Said Khairul Anwar Mohamad , Abdulyekeen Kabir Abogunde , Ismail Ahmad Fauzi , Rahman Mukhlis A. , Jaafar Juhana , Abu Bakar Suriani
Published: December 2021

This research aimed to investigate the ultrafiltration of water from emulsified oily wastewater through the application of surface-functionalized ceramic membrane to enhance its water permeability based on optimized parameters using a cross-flow filtration system. The interactive effects of feed concentration (10–1000 ppm), pH (4–10), and pressure (0–3 bar) on the water flux and oil rejection were investigated. Central composite design (CCD) from response surface methodology (RSM) was employed for statistical analysis, modeling, and optimization of operating conditions. The analysis of variance (ANOVA) results showed that the oil rejection and water flux models were significant with p-values of 0.0001 and 0.0075, respectively. In addition, good correlation coefficients of 0.997 and 0.863 were obtained for the oil rejection and water flux models, respectively. The optimum conditions for pressure, pH, and feed concentration were found to be 1.5 bar, pH 8.97, and 10 ppm, respectively with water flux and oil rejection maintained at 152 L/m2·h and 98.72%, respectively. Hence, the functionalized ultrafiltration ceramic membrane enables the separation efficiency of the emulsified oil in water to be achieved.
Comparison between Membrane and Thermal Dealcoholization Methods: Their Impact on the Chemical Parameters, Volatile Composition, and Sensory Characteristics of Wines
Authors: Sam Faisal Eudes , Ma Tengzhen , Liang Yuhua , Qiang Wenle , Atuna Richard Atinpoore , Amagloh Francis Kweku , Morata Antonio , Han Shunyu
Published: December 2021

Over the last few years, the dealcoholization of wine has piqued the interest of winemakers and researchers. Physical dealcoholization methods are increasingly used in the dealcoholization of wines because they can partially or completely reduce the alcohol content of wines. This study aimed to compare the chemical parameters, volatile composition and sensory quality of white, rosé and red wines dealcoholized by two physical dealcoholization methods: reverse osmosis (RO) and vacuum distillation (VD) at 0.7% v/v ethanol. RO and VD effectively reduced the ethanol concentration in all wines to the required 0.7% v/v, but also significantly affected most chemical parameters. The pH, free sulfur dioxide, total sulfur dioxide, and volatile acidity decreased significantly due to dealcoholization by RO and VD, while reducing sugars and total acidity increased significantly. VD resulted in higher color intensity, which was perceptible in dealcoholized rosé and red wines, while RO caused notable color differences in dealcoholized white and red wine fractions. RO were richer in esters (more ethyl esters and isoamyl acetate), higher alcohols, organic acids, terpenics and C13-norisoprenoids, and carbonyl compounds, while wines dealcoholized with VD had lower levels of these volatile compounds, which may reflect both the loss of esters into the distillate during evaporation and condensation (in the case of VD) and a shift in the chemical equilibrium responsible for ester formation and hydrolysis after ethanol removal. β-damascenone exhibited the highest OAV in all wines, however, losses equal to 35.54–61.98% in RO dealcoholized fractions and 93.62% to 97.39% in VD dealcoholized fractions were observed compared to the control wines. The predominant aroma series in the original and dealcoholized wines were fruity and floral but were greatly affected by VD. Sensory evaluation and PCA showed that dealcoholization by RO improved the fruity and floral notes (in rosé and red wines), color intensity, sweetness, viscosity, and aroma intensity better than dealcoholization by VD, while VD mainly enhanced the color of the dealcoholized wines. Both methods increased the acidity of the respective dealcoholized wines. Nevertheless, RO dealcoholized wines achieved higher acceptance by the panelists than VD dealcoholized wines. Therefore, RO may be a better method for producing dealcoholized (0.7% v/v) wines with minimal impact on aroma and sensory quality.
Identification of an Exopolysaccharide Biosynthesis Gene in Bradyrhizobium diazoefficiens USDA110
Authors: Xu Chunxia , Ruan Huaqin , Cai Wenjie , Staehelin Christian , Dai Weijun
Published: December 2021

Exopolysaccharides (EPS) play critical roles in rhizobium-plant interactions. However, the EPS biosynthesis pathway in Bradyrhizobium diazoefficiens USDA110 remains elusive. Here we used transposon (Tn) mutagenesis with the aim to identify genetic elements required for EPS biosynthesis in B. diazoefficiens USDA110. Phenotypic screening of Tn5 insertion mutants grown on agar plates led to the identification of a mutant with a transposon insertion site in the blr2358 gene. This gene is predicted to encode a phosphor-glycosyltransferase that transfers a phosphosugar onto a polyprenol phosphate substrate. The disruption of the blr2358 gene resulted in defective EPS synthesis. Accordingly, the blr2358 mutant showed a reduced capacity to induce nodules and stimulate the growth of soybean plants. Glycosyltransferase genes related to blr2358 were found to be well conserved and widely distributed among strains of the Bradyrhizobium genus. In conclusion, our study resulted in identification of a gene involved in EPS biosynthesis and highlights the importance of EPS in the symbiotic interaction between USDA110 and soybeans.
Probiotic Bacillus safensis NPUST1 Administration Improves Growth Performance, Gut Microbiota, and Innate Immunity against Streptococcus iniae in Nile tilapia (Oreochromis niloticus)
Authors: Wu Pei-Shan , Liu Chun-Hong , Hu Shao-Yang
Published: December 2021

Probiotics are considered ecofriendly alternatives to antibiotics as immunostimulants against pathogen infections in aquaculture. In the present study, protease-, amylase-, cellulase-, and xylanase-producing Bacillus safensis NPUST1 were isolated from the gut of Nile tilapia, and the beneficial effects of B. safensis NPUST1 on growth, innate immunity, disease resistance and gut microbiota in Nile tilapia were evaluated by feeding tilapia a basal diet or basal diet containing 105 and 106–107 CFU/g for 8 weeks. The results showed that the weight gain, feed efficiency and specific growth rate were significantly increased in tilapia fed a diet containing 106 CFU/g and 107 CFU/g B. safensis NPUST1. Intestinal digestive enzymes, including protease, amylase and lipase, and hepatic mRNA expression of glucose metabolism and growth-related genes, such as GK, G6Pase, GHR and IGF-1, were also significantly increased in the 106 CFU/g and 107 CFU/g B. safensis NPUST1 treated groups. Immune parameters such as phagocytic activity, respiratory burst and superoxide dismutase activity in head kidney leukocytes, serum lysozyme, and the mRNA expression of IL-1β, IL-8, TNF-α and lysozyme genes were significantly induced in the head kidney and spleen of 106 CFU/g and 107 CFU/g B. safensis NPUST1 treated fish. The cumulative survival rate was significantly increased in fish fed a diet containing 106 CFU/g and 107 CFU/g B. safensis NPUST1 after challenge with Streptococcus iniae. Dietary supplementation with B. safensis NPUST1 improves the gut microbiota of Nile tilapia, which increases the abundance of potential probiotics and reduces the abundance of pathogenic pathogens. The present study is the first to report the use of B. safensis as a potential probiotic in aquaculture, and a diet containing 106 CFU/g B. safensis NPUST1 is adequate for providing beneficial effects on growth performance and health status in tilapia.
The Reserve/Maximum Capacity of Melatonin’s Synthetic Function for the Potential Dimorphism of Melatonin Production and Its Biological Significance in Mammals
Authors: Tan Dun-Xian , Hardeland Rüdiger
Published: December 2021

In this article, we attempt to classify a potential dimorphism of melatonin production. Thus, a new concept of “reserve or maximum capacity of melatonin synthetic function” is introduced to explain the subtle dimorphism of melatonin production in mammals. Considering ASMT/ASMTL genes in the pseudoautosomal region of sex chromosomes with high prevalence of mutation in males, as well as the sex bias of the mitochondria in which melatonin is synthesized, we hypothesize the existence of a dimorphism in melatonin production to favor females, which are assumed to possess a higher reserve capacity for melatonin synthesis than males. Under physiological conditions, this subtle dimorphism is masked by the fact that cells or tissues only need baseline melatonin production, which can be accomplished without exploiting the full potential of melatonin’s synthetic capacity. This capacity is believed to exceed the already remarkable nocturnal increase as observed within the circadian cycle. However, during aging or under stressful conditions, the reserve capacity of melatonin’s synthetic function is required to be activated to produce sufficiently high levels of melatonin for protective purposes. Females seem to possess a higher reserve/maximum capacity for producing more melatonin than males. Thus, this dimorphism of melatonin production becomes manifest and detectable under these conditions. The biological significance of the reserve/maximum capacity of melatonin’s synthetic function is to improve the recovery rate of organisms from injury, to increase resistance to pathogen infection, and even to enhance their chances of survival by maximizing melatonin production under stressful conditions. The higher reserve/maximum capacity of melatonin synthesis in females may also contribute to the dimorphism in longevity, favoring females in mammals.
Innate Immunity Modulating Impurities and the Immunotoxicity of Nanobiotechnology-Based Drug Products
Authors: Holley Claire K. , Dobrovolskaia Marina A.
Published: December 2021

Innate immunity can be triggered by the presence of microbial antigens and other contaminants inadvertently introduced during the manufacture and purification of bionanopharmaceutical products. Activation of these innate immune responses, including cytokine secretion, complement, and immune cell activation, can result in unexpected and undesirable host immune responses. These innate modulators can also potentially stimulate the activation of adaptive immune responses, including the formation of anti-drug antibodies which can impact drug effectiveness. To prevent induction of these adverse responses, it is important to detect and quantify levels of these innate immunity modulating impurities (IIMIs) that may be present in drug products. However, while it is universally agreed that removal of IIMIs from drug products is crucial for patient safety and to prevent long-term immunogenicity, there is no single assay capable of directly detecting all potential IIMIs or indirectly quantifying downstream biomarkers. Additionally, there is a lack of agreement as to which of the many analytical assays currently employed should be standardized for general IIMI screening. Herein, we review the available literature to highlight cellular and molecular mechanisms underlying IIMI-mediated inflammation and its relevance to the safety and efficacy of pharmaceutical products. We further discuss methodologies used for direct and indirect IIMI identification and quantification.
Measurement and Analysis of RSS Using Bluetooth Mesh Network for Localization Applications
Authors: Cao Yuan , Kandula Harsha , Li Xinrong
Published: December 2021

Bluetooth low energy (BLE)-based location service technology has become one of the fastest growing applications for Bluetooth. Received signal strength (RSS) is often used in localization techniques for ranging or location fingerprinting. However, RSS-based localization solutions have poor performance in multipath environments. In this paper, we present a measurement system designed using multiple ESP32 BLE modules and the Bluetooth mesh networking technology, which is capable of exploiting the space, time, and frequency diversities in measurements. To enable channel-aware multi-device RSS measurements, we also designed a communication protocol to associate channel ID information to advertising messages. Based on channel measurement and analysis, we demonstrate that with a six-receiver configuration and space-time-frequency diversity combining, we can significantly reduce the residual linear regression fitting errors in path loss models. Such a reduction leads to more accurately correlating RSS measurements to the distance between the transmitter and receiver devices and thus to achieving improved performance with the RSS-based localization techniques. More importantly, the reduction in the fitting errors is achieved without differentiating the three advertising channels, making it possible to conveniently implement the proposed six-receiver configuration using commercially available BLE devices and the standard Bluetooth mesh networking protocol stack.
The Association between 25-Hydroxyvitamin D Concentration and Telomere Length in the Very-Old: The Newcastle 85+ Study
Authors: Hakeem Sarah , Mendonça Nuno , Aspray Terry , Kingston Andrew , Martin-Ruiz Carmen , Robinson Louise , Hill Tom R.
Published: December 2021

(1) Introduction: vitamin D may maintain the telomere length, either directly or via the inflammation effect and/or modulating the rate of cell proliferation. Whilst results from cross-sectional studies investigating the association between 25(OH)D concentration and telomere length have been mixed, there is a dearth of data from prospective studies which have assessed these associations. This study aimed to examine the association between 25(OH)D concentration in plasma and telomere length in blood cells in very-old adults (≥85 years old) at baseline, 18 months and 36 months by controlling for related lifestyle factors. (2) Methodology: our prospective cohort study comprised 775 participants from the Newcastle 85+ Study who had 25(OH)D measurements at baseline. Plasma 25(OH)D was stratified as <25 nmol/L (low), 25–50 nmol/L (moderate) and >50 nmol/L (high). Peripheral blood mononuclear cell telomere length was measured by quantitative real-time polymerase chain reaction at baseline, 18 and 36 months from baseline. (3) Results: a positive significant association was found between 25(OH)D concentration and telomere length amongst very-old participants at baseline (95% CI = 12.0–110.3, B = 61.2 ± 5.0, p = 0.015). This association was negative at 18 months (95% CI = −59.9–−7.5, B = −33.7 ± 13.3, p = 0.012) but was non-significant at 36 months. (4) Conclusion: Circulating 25(OH)D concentration shows inconsistent relationships with telomere length over time in very-old (85+ year old) adults.
FXR, a Key Regulator of Lipid Metabolism, Is Inhibited by ER Stress-Mediated Activation of JNK and p38 MAPK in Large Yellow Croakers (Larimichthys crocea) Fed High Fat Diets
Authors: Du Jianlong , Xiang Xiaojun , Xu Dan , Zhang Junzhi , Fang Wei , Xu Wei , Mai Kangsen , Ai Qinghui
Published: December 2021

High-fat diets induced abnormal lipid accumulation in the liver of cultured fish that caused body damage and diseases. The purpose of this research was to investigate the role and mechanism of farnesoid X receptor (FXR) in regulating lipid metabolism and to determine how high-fat diets affect FXR expression in large yellow croakers. The results showed that ligand-meditated FXR-activation could prevent abnormal lipid accumulation in the liver and hepatocytes of large yellow croakers. FXR activation increased the expression of lipid catabolism-related genes while decreasing the expression of lipogenesis-related genes. Further investigation found that the promoter activity of proliferator-activated receptor α (PPARα) could be increased by croaker FXR. Through the influence of SHP on LXR, FXR indirectly decreased the promoter activity of sterol regulatory element binding protein 1 (SREBP1) in large yellow croakers. Furthermore, the findings revealed that endoplasmic reticulum (ER)-stress-induced-activation of JNK and P38 MAPK participated in the reduction of FXR induced by high-fat diets. Then, hepatocyte nuclear factor 1α (HNF1α) was confirmed to be an FXR regulator in large yellow croaker, and it was reduced by high-fat diets and ER stress. In addition, co-expression of c-Jun with HNF1α inhibited the effect of HNF1α on FXR promoter, and suppression of P38 MAPK could relieve the HNF1α expression reduction caused by ER stress activation. In summary, the present study showed that FXR mediated lipid metabolism can prevent abnormal lipid accumulation through regulating PPARα and SREBP1 in large yellow croakers, while high-fat diets can suppress FXR expression by ER stress mediated-activation of JNK and P38 MAPK pathways. This research could benefit the study of FXR functions in vertebrate evolution and the development of therapy or preventative methods for nutrition-related disorders.
Wound Antiseptics and European Guidelines for Antiseptic Application in Wound Treatment
Authors: Babalska Zuzanna Łucja , Korbecka-Paczkowska Marzena , Karpiński Tomasz M.
Published: December 2021

Issues arising in wound healing are very common, and chronic wound infections affect approximately 1.5% of the population. The main substances used in wound washing, cleansing and treatment are antiseptics. Today, there are many compounds with a known antiseptic activity. Older antiseptics (e.g., boric acid, ethacridine lactate, potassium permanganate, hydrogen peroxide, iodoform, iodine and dyes) are not recommended for wound treatment due to a number of disadvantages. According to the newest guidelines of the Polish Society for Wound Treatment and the German Consensus on Wound Antisepsis, only the following antiseptics should be taken into account for wound treatment: octenidine (OCT), polihexanide (PHMB), povidone-iodine (PVP-I), sodium hypochlorite (NaOCl) and nanosilver. This article provides an overview of the five antiseptics mentioned above, their chemical properties, wound applications, side effects and safety.
Climate Change Impacts on Sunflower (Helianthus annus L.) Plants
Authors: Agüera Eloísa , de la Haba Purificación
Published: December 2021

The biochemical, biological, and morphogenetic processes of plants are affected by ongoing climate change, causing alterations in crop development, growth, and productivity. Climate change is currently producing ecosystem modifications, making it essential to study plants with an improved adaptive capacity in the face of environmental modifications. This work examines the physiological and metabolic changes taking place during the development of sunflower plants due to environmental modifications resulting from climate change: elevated concentrations of atmospheric carbon dioxide (CO2) and increased temperatures. Variations in growth, and carbon and nitrogen metabolism, as well as their effect on the plant’s oxidative state in sunflower (Helianthus annus L.) plants, are studied. An understanding of the effect of these interacting factors (elevated CO2 and elevated temperatures) on plant development and stress response is imperative to understand the impact of climate change on plant productivity.
Toughening Mechanism Analysis of Recycled Rubber-Based Composites Reinforced with Glass Bubbles, Glass Fibers and Alumina Fibers
Authors: Kabakci Gamze Cakir , Aslan Ozgur , Bayraktar Emin
Published: December 2021

Recycling of materials attracts considerable attention around the world due to environmental and economic concerns. Recycled rubber is one of the most commonly used recyclable materials in a number of industries, including automotive and aeronautic because of their low weight and cost efficiency. In this research, devulcanized recycled rubber-based composites are designed with glass bubble microsphere, short glass fiber, aluminum chip and fine gamma alumina fiber (γ-Al2O3) reinforcements. After the determination of the reinforcements with matrix, bending strength and fracture characteristics of the composite are investigated by three-point bending (3PB) tests. Halpin–Tsai homogenization model is adapted to the rubber-based composites to estimate the moduli of the composites. Furthermore, the relevant toughening mechanisms for the most suitable reinforcements are analyzed and stress intensity factor, KIc and critical energy release rate, GIc in mode I are determined by 3PB test with single edge notch specimens. In addition, 3PB tests are simulated by finite element analysis and the results are compared with the experimental results. Microstructural and fracture surfaces analysis are carried out by means of scanning electron microscopy (SEM). Mechanical test results show that the reinforcement with glass bubbles, aluminum oxide ceramic fibers and aluminum chips generally increase the fracture toughness of the composites.
Calculation of Bandwidth of Multimode Step-Index Polymer Photonic Crystal Fibers
Authors: Drljača Branko , Savović Svetislav , Kovačević Milan S. , Simović Ana , Kuzmanović Ljubica , Djordjevich Alexandar , Min Rui
Published: December 2021

By solving the time-dependent power flow equation, we present a novel approach for evaluating the bandwidth in a multimode step-index polymer photonic crystal fiber (SI PPCF) with a solid core. The bandwidth of such fiber is determined for various layouts of air holes and widths of Gaussian launch beam distribution. We found that the lower the NA of SI PPCF, the larger the bandwidth. The smaller launch beam leads to a higher bandwidth for short fibers. The influence of the width of the launch beam distribution on bandwidth lessens as the fiber length increases. The bandwidth tends to its launch independent value at a particular fiber length. This length denotes the onset of the steady state distribution (SSD). This information is useful for multimode SI PPCF applications in telecommunications and optical fiber sensing applications.
In Vitro Cellular Uptake and Transfection of Oligoarginine-Conjugated Glycol Chitosan/siRNA Nanoparticles
Authors: Jeong Eun-Ju , Lee Jangwook , Kim Hyun-Seung , Lee Kuen-Yong
Published: December 2021

Chitosan and its derivatives have been extensively utilized in gene delivery applications because of their low toxicity and positively charged characteristics. However, their low solubility under physiological conditions often limits their application. Glycol chitosan (GC) is a derivative of chitosan that exhibits excellent solubility in physiological buffer solutions. However, it lacks the positive characteristics of a gene carrier. Thus, we hypothesized that the introduction of oligoarginine peptide to GC could improve the formation of complexes with siRNA, resulting in enhanced uptake by cells and increased transfection efficiency in vitro. A peptide with nine arginine residues and 10 glycine units (R9G10) was successfully conjugated to GC, which was confirmed by infrared spectroscopy, 1H NMR spectroscopy, and elemental analysis. The physicochemical characteristics of R9G10-GC/siRNA complexes were also investigated. The size and surface charge of the R9G10-GC/siRNA nanoparticles depended on the amount of R9G10 coupled to the GC. In addition, the R9G10-GC/siRNA nanoparticles showed improved uptake in HeLa cells and enhanced in vitro transfection efficiency while maintaining low cytotoxicity determined by the MTT assay. Oligoarginine-modified glycol chitosan may be useful as a potential gene carrier in many therapeutic applications.
Two Birds with One Stone: Preparation of 4, 4-Diaminodiphenylmethane Functionalized GO@SiO2 with Mechanical Reinforcement and UV Shielding Properties and Its Application in Thermoplastic Polyurethane
Authors: Ding Guoxin , Tai Hongxu , Chen Chuanxin , Sun Chenfeng , Tang Zhongfeng
Published: December 2021

This study prepared 4,4-diaminodiphenylmethane (DDM)-functionalized graphene oxide (GO)@silica dioxide (SiO2) nano-composites through amidation reaction and low-temperature precipitation. The resulting modified GO, that was DDM−GO@SiO2. The study found that DDM−GO@SiO2 showed good dispersion and compatibility with thermoplastic polyurethane (TPU) substrates. Compared with pure TPU, the tensile strength of the TPU composites increased by 41% to 94.6 MPa at only 0.5 wt% DDM−GO@SiO2. In addition, even when a small amount of DDM−GO@SiO2 was added, the UV absorption of TPU composites increased significantly, TPU composites can achieve a UV shielding efficiency of 95.21% in the UV-A region. These results show that this type of material holds great promise for the preparation of functional coatings and film materials with high strength and weather resistance.
Compressive Failure Mechanism of Structural Bamboo Scrimber
Authors: Wang Xueyu , Zhong Yong , Luo Xiangya , Ren Haiqing
Published: December 2021

Bamboo scrimber is one of the most popular engineering bamboo composites, owing to its excellent physical and mechanical properties. In order to investigate the influence of grain direction on the compression properties and failure mechanism of bamboo scrimber, the longitudinal, radial and tangential directions were selected. The results showed that the compressive load–displacement curves of bamboo scrimber in the longitudinal, tangential and radial directions contained elastic, yield and failure stages. The compressive strength and elastic modulus of the bamboo scrimber in the longitudinal direction were greater than those in the radial and tangential directions, and there were no significant differences between the radial and tangential specimens. The micro-fracture morphology shows that the parenchyma cells underwent brittle shear failure in all three directions, while the fiber failure of the longitudinal compressive specimens consisted of ductile fracture, and the tangential and radial compressive specimens exhibited brittle fracture. This is one of the reasons that the deformation of the specimens under longitudinal compression was greater than those under tangential and radial compression. The main failure mode of bamboo scrimber under longitudinal and radial compression was shear failure, and the main failure mode under tangential compression was interlayer separation failure. The reason for this difference was that during longitudinal and radial compression, the maximum strain occurred at the diagonal of the specimen, while during tangential compression, the maximum strain occurred at the bonding interface. This study can provide benefits for the rational design and safe application of bamboo scrimber in practical engineering.
Regulation of Hydrogen Peroxide Dosage in a Heterogeneous Photo-Fenton Process
Authors: Saldaña-Flores Karla Estefanía , Flores-Estrella René Alejandro , Alcaraz-Gonzalez Victor , Carissimi Elvis , de Souza Bruna Gonçalves , Ruotolo Luís Augusto Martins , Urquieta-Gonzalez Ernesto
Published: December 2021

In this work, a classical linear control approach for the peroxide (H2O2) dosage in a photo-Fenton process is presented as a suitable solution for improving the efficiency in the treatment of recalcitrant organic compounds that cannot be degraded by classical wastewater treatment processes like anaerobic digestion. Experiments were carried out to degrade Lignin, Melanoidin, and Gallic acid, which are typical recalcitrant organic compounds present in some kinds of effluents such as vinasses from the Tequila and Cachaça industries. Experiments were carried in Open-Loop mode for obtaining the degradation model for the three compounds in the form of a Transfer Function, and in Closed-Loop mode for controlling the concentration of each compound. First-order Transfer Functions were obtained using the reaction curve method, and then, based on these models, the parameters of Proportional Integral controllers were calculated using the direct synthesis method. In the Closed-Loop experiments, the Total Organic Carbon removal was 39% for lignin, 7% for melanoidin, and 29% for Gallic acid, which were greater than those obtained in the Open-Loop experiments.
Probing Differences in Mass-Transfer Coefficients in Beaker and Stirrer Digestion Systems and the USP Dissolution Apparatus 2 Using Benzoic Acid Tablets
Authors: Langrish Timothy A. G. , Zhong Chao , Sun Lizhe
Published: December 2021

Measurements of external mass-transfer coefficients for dissolution have been made with benzoic acid tablets with a diameter of 13 mm and approximately 3 mm thick, using two different dissolution systems. One system has been a beaker with a platform for the tablet and either 80 mL or 120 mL of water, with three different types of stirrers, and the other has been a USP dissolution apparatus 2 (paddle) with either 200 mL or 900 mL water. Various stirring speeds have also been used in the different pieces of equipment. The same mass-transfer coefficient may potentially be obtained from the same tablet by adjusting the operating conditions in the two different devices. The ranges of the external mass-transfer coefficients measured in both devices overlapped significantly, with the range being 0.193–4.48 × 10−5 m s−1 in the beaker and stirrer system and 0.222–3.45 × 10−5 m s−1 in the USP dissolution apparatus 2. Dimensional analysis of the results, using Sherwood and Reynolds numbers, shows that the Ranz–Marshall correlation provides a lower bound for estimates of the Sherwood numbers measured experimentally. Calculations of time constants for mass transfer suggest that mass transfer may be a rate-limiting step for dissolution and food digestion under some circumstances. The range of mass-transfer coefficients measured here is representative of other measurements from the literature, and the use of the Ranz–Marshall correlation supports the suggestion that this range of values should be generally expected in most situations.
Ultrasound-Assisted Multi-Enzymatic System for the Preparation of ACE Inhibitory Peptides with Low Bitterness from Corn Gluten Meal
Authors: Huang Shanfen , Li Yunliang , Li Chengliang , Ruan Siyu , Qu Wenjuan , Ding Yanhua , Ye Xiaofei , Ma Haile
Published: December 2021

The promising angiotensin converting enzyme (ACE) inhibitory peptides derived from corn protein usually have strong bitterness and thus limit their use among consumers. To prepare ACE inhibitory peptides with low bitterness, two energy-efficient types of ultrasound pretreatment were introduced into the multi-enzymatic system of corn gluten meal. The results showed that Flavourzyme–Protamex sequential enzymolysis produced the peptides with high ACE inhibitory activity and the lowest bitterness compared with other enzymolysis conditions. During the optimized sequential enzymolysis, the divergent ultrasound pretreatment with a frequency of 40 kHz for 60 min exhibited higher ACE inhibitory activity (65.36%, accounting for 73.84% of the highest ACE inhibitory activity) and lower bitterness intensity of peptides, compared with an energy-gathered ultrasound. The results of the study showed that, on the one hand, divergent ultrasound pretreatment induced the highest intrinsic fluorescence of protein, with more hydrophobic amino acid residues exposed for cleavage by exopeptidases, which leads to a reduction in bitterness. On the other hand, the amino acid composition analysis proved that more Tyr, Ile, and Val moieties, instead of Leu (bitterest substance), and more peptide fractions with a molecular weight >1000 Da should be the structural features of high ACE inhibitory peptides.
Efficient and Safe Robotic Autonomous Environment Exploration Using Integrated Frontier Detection and Multiple Path Evaluation
Authors: Sun Yuxi , Zhang Chengrui
Published: December 2021

Autonomous exploration and remote sensing using robots have gained increasing attention in recent years and aims to maximize information collection regarding the external world without human intervention. However, incomplete frontier detection, an inability to eliminate inefficient frontiers, and incomplete evaluation limit further improvements in autonomous exploration efficiency. This article provides a systematic solution for ground mobile robot exploration with high efficiency. Firstly, an integrated frontier detection and maintenance method is proposed, which incrementally discovers potential frontiers and achieves incremental maintenance of the safe and informative frontiers by updating the distance map locally. Secondly, we propose a novel multiple paths planning method to generate multiple paths from the robot position to the unexplored frontiers. Then, we use the proposed utility function to select the optimal path and improve its smoothness using an iterative optimization strategy. Ultimately, the model predictive control (MPC) method is applied to track the smooth path. Simulation experiments on typical environments demonstrate that compared with the benchmark methods, the proposed method reduce the path length by 27.07% and the exploration time by 27.09% on average. The real-world experimental results also reveal that our proposed method can achieve complete mapping with fewer repetitive paths.
A Novel Method for Layover Detection in Mountainous Areas with SAR Images
Authors: Wu Lin , Wang Hongxia , Li Yuan , Guo Zhengwei , Li Ning
Published: December 2021

It is well known that there are geometric distortions in synthetic aperture radar (SAR) images when the terrain undulates. Layover is the most common one, which brings challenges to the application of SAR remote sensing. This study proposes a novel detection method that is mainly aimed at the layover caused by mountains and can be performed with only medium-resolution SAR images and no other auxiliary data. The detection includes the following four stages: initial processing, difference image calculation and rough and fine layover detection. Initial processing mainly obtains the potential layover areas, which are mixed with the built-up areas after classification. Additionally, according to the analysis of the backscatter coefficient (BC) of various ground objects with different polarization images, the layover areas are detected step-by-step from the mixed areas, in which the region-based FCM segmentation algorithm and spatial relationship criteria are used. Taking the Danjiangkou Reservoir area as the study area, the relevant experiments with Sentinel-1A SAR images were conducted. The quantitative analysis of detection results adopted the figure of merit (FoM), and the highest accuracy was up to 87.6% of one selected validation region. Experiments in the South Taihang area also showed the satisfactory effect of layover detection, and the values of FoM were all above 85%. These results show that the proposed method can do well in the layover detection caused by mountains. Its simplicity and effectiveness are helpful in removing the influence of layover on SAR image applications to a certain extent and improving the development of SAR remote sensing technology.