bluuebunny/crossref_metadata_2025 huggingface dataset:
Liver-resident memory T cells: life in lockdown
Authors: Pallett Laura J. , Maini Mala K.
Published: April 2022

A subset of memory T cells has been identified in the liver with a tissue-resident profile and the capacity for long-term ‘lockdown’. Here we review how they are retained in, and adapted to, the hepatic microenvironment, including its unique anatomical features and metabolic challenges. We describe potential interactions with other local cell types and the need for a better understanding of this complex bidirectional crosstalk. Pathogen or tumour antigen-specific tissue-resident memory T cells (TRM) can provide rapid frontline immune surveillance; we review the evidence for this in hepatotropic infections of major worldwide importance like hepatitis B and malaria and in liver cancers like hepatocellular carcinoma. Conversely, TRM can be triggered by pro-inflammatory and metabolic signals to mediate bystander tissue damage, with an emerging role in a number of liver pathologies. We discuss the need for liver sampling to gain a window into these compartmentalised T cells, allowing more accurate disease monitoring and future locally targeted immunotherapies.
Traveling waves of an FKPP-type model for self-organized growth
Authors: Kreten Florian
Published: April 2022

We consider a reaction–diffusion system of densities of two types of particles, introduced by Hannezo et al. (Cell 171(1):242–255.e27, 2017). It is a simple model for a growth process: active, branching particles form the growing boundary layer of an otherwise static tissue, represented by inactive particles. The active particles diffuse, branch and become irreversibly inactive upon collision with a particle of arbitrary type. In absence of active particles, this system is in a steady state, without any a priori restriction on the amount of remaining inactive particles. Thus, while related to the well-studied FKPP-equation, this system features a game-changing continuum of steady state solutions, where each corresponds to a possible outcome of the growth process. However, simulations indicate that this system self-organizes: traveling fronts with fixed shape arise under a wide range of initial data. In the present work, we describe all positive and bounded traveling wave solutions, and obtain necessary and sufficient conditions for their existence. We find a surprisingly simple symmetry in the pairs of steady states which are joined via heteroclinic wave orbits. Our approach is constructive: we first prove the existence of almost constant solutions and then extend our results via a continuity argument along the continuum of limiting points.
Accelerated Optimization on Riemannian Manifolds via Discrete Constrained Variational Integrators
Authors: Duruisseaux Valentin , Leok Melvin
Published: April 2022

A variational formulation for accelerated optimization on normed vector spaces was recently introduced in Wibisono et al. (PNAS 113:E7351–E7358, 2016), and later generalized to the Riemannian manifold setting in Duruisseaux and Leok (SJMDS, 2022a). This variational framework was exploited on normed vector spaces in Duruisseaux et al. (SJSC 43:A2949–A2980, 2021) using time-adaptive geometric integrators to design efficient explicit algorithms for symplectic accelerated optimization, and it was observed that geometric discretizations which respect the time-rescaling invariance and symplecticity of the Lagrangian and Hamiltonian flows were substantially less prone to stability issues, and were therefore more robust, reliable, and computationally efficient. As such, it is natural to develop time-adaptive Hamiltonian variational integrators for accelerated optimization on Riemannian manifolds. In this paper, we consider the case of Riemannian manifolds embedded in a Euclidean space that can be characterized as the level set of a submersion. We will explore how holonomic constraints can be incorporated in discrete variational integrators to constrain the numerical discretization of the Riemannian Hamiltonian system to the Riemannian manifold, and we will test the performance of the resulting algorithms by solving eigenvalue and Procrustes problems formulated as optimization problems on the unit sphere and Stiefel manifold.
July–September rainfall in the Greater Horn of Africa: the combined influence of the Mascarene and South Atlantic highs
Authors: Dyer Ellen , Hirons Linda , Taye Meron Teferi
Published: April 2022

July-September rainfall is a key component of Ethiopia’s annual rainfall and is a source of rainfall variability throughout inland Greater Horn of Africa. In this study we investigate the relative influences of the Mascarene (MH) and South Atlantic (AH) highs on July-September rainfall in a covarying region of the Greater Horn of Africa using CHIRPS observed rainfall and the ERA5 reanalysis. We show that a mixed metric using the circulation at 850 hPa of these two subtropical anticyclones (AH-MH), is better correlated with rainfall than individual high circulations. Variations in remote circulation are translated by changes in Central African westerlies and Turkana Jet wind speeds. We apply the AH-MH mixed metric to the CMIP5 and CMIP6 ensembles and show that it is a good indicator of mean July-September rainfall across both ensembles. Biases in circulation are shown to be related to the Hadley circulation in CMIP5 atmosphere-only simulations, while causes of biases in CMIP6 are more varied. Coupled model biases are related to southern ocean warm biases in CMIP5 and western Indian Ocean warm biases in CMIP6. CMIP6 shows an improved relationship between rainfall and Turkana Jet winds and Central African westerlies across the ensemble.
Long-term effects of preeclampsia on maternal cardiovascular health and postpartum utilization of primary care: an observational claims data study
Authors: Haßdenteufel Kathrin , Müller Mitho , Gutsfeld Raphael , Goetz Maren , Bauer Armin , Wallwiener Markus , Brucker Sara Y. , Joos Stefanie , Colombo Miriam Giovanna , Hawighorst-Knapstein Sabine , Chaudhuri Ariane , Kirtschig Gudula , Saalmann Frauke , Wallwiener Stephanie
Published: April 2022

Purpose

Preeclampsia occurs in up to 15% of pregnancies and constitutes a major risk factor for cardiovascular disease. This observational cohort study aimed to examine the association between preeclamptic pregnancies and cardiovascular outcomes as well as primary and specialized care utilization after delivery.

Methods

Using statutory claims data we identified women with singleton live births between 2010 and 2017. Main outcomes included the occurrence of either hypertension or cardiovascular disease after one or more preeclamptic pregnancies, number of contacts to a general practitioner or cardiologist after delivery and prescribed antihypertensive medication. Data were analyzed using Cox proportional hazard regression models adjusted for maternal age, diabetes, dyslipidemia, and obesity.

Results

The study cohort consisted of 181,574 women with 240,698 births. Women who experienced preeclampsia once had an increased risk for cardiovascular (hazard ratio, HR = 1.29) or hypertensive (HR = 4.13) events. In women affected by recurrent preeclampsia, risks were even higher to develop cardiovascular disease (HR = 1.53) or hypertension (HR = 6.01). In the following years after delivery, general practitioners were seen frequently, whereas cardiologists were consulted rarely (0.3 and 2.4%).

Conclusion

Women affected by preeclampsia experience an increased risk of developing chronic hypertension and cardiovascular disease, especially those with recurrent preeclampsia. Future medical guidelines should take this potential risk into account.
Galileo Galilei and the centers of gravity of solids: a reconstruction based on a newly discovered version of the conical frustum contained in manuscript UCLA 170/624
Authors: Bellé Riccardo , Sisana Beatrice
Published: April 2022

The manuscript UCLA 170/624 (ff. 75–76) contains Galileo’s proof of the center of gravity of the frustum of a cone, which was ultimately published as Theoremata circa centrum gravitatis solidorum in Discorsi e dimostrazioni matematiche intorno a due nuove scienze (Leiden 1638). The UCLA copy opens the possibility of giving a fuller account of Theoremata dating and development, and it can shed light on the origins of this research by the young Galileo. A comparison of the UCLA manuscript with the other extant copies is carried out to propose a new dating for the composition of the Theoremata. This dating will then be reconsidered in light of the mathematical content. The paper ends with a complete description of the content of the UCLA manuscript and the edition of Galileo’s text there contained.
Technical feasibility and perioperative outcome of laparoscopic resection rectopexy with natural orifice specimen extraction (NOSE) and intracorporeal anastomosis (ICA)
Authors: Driouch Jamal , Thaher Omar , Alnammous Ghaith , Dehnst Joachim , Bausch Dirk , Glatz Torben
Published: April 2022

Purpose

Laparoscopic rectosigmoid resection rectopexy (LRR) is the most effective treatment of obstructive defecation syndrome but is associated with a higher postoperative morbidity compared to transanal approaches. Natural orifice specimen extraction (NOSE) has been described as a promising technique to lower morbidity in colorectal cancer surgery. In this study, we analyze the technical challenges of adapting this technique to LRR and compare the perioperative results to the conventional laparoscopic technique with specimen extraction via minilaparotomy and extracorporeal anastomosis.

Methods

We retrospectively analyzed 45 patients who underwent laparoscopic rectosigmoid resection rectopexy due to obstructive defecation syndrome at our institutions. From September 2020 to July 2021, we treated 17 consecutive patients with NOSE-LRR and compared the results to a historic cohort of 28 consecutive patients treated with conventional laparoscopic rectosigmoid resection rectopexy plus minilaparotomy (LAP-LRR) for specimen extraction between January 2019 and July 2020. Assessed were patient- and disease-specific parameters, operative time, hospital and postoperative complications and subjective patient satisfaction after 6 months of follow-up.

Results

Both groups were comparable in terms of gender distribution, age, and comorbidities. The median operating time was similar and the perioperative morbidity was comparable in both groups. The length of stay in hospital was significantly shorter in the NOSE-LRR group (median 6 vs 8 days).

Conclusion

NOSE-LRR can be implemented safely, performed in a comparable operating time, and is associated with a comparable rate of postoperative complications. The technique offers the a potentially fast postoperative recovery compared to the conventional laparoscopic technique.
QTc prolongation in adolescents with acute alcohol intoxication
Authors: de Veld Loes , van der Lely Nico , Hermans Ben J. M. , van Hoof Joris J. , Wong Lichelle , Vink Arja Suzanne
Published: April 2022

In adults, alcohol intoxication is associated with prolongation of the QT interval corrected for heart rate (QTc). The QTc is influenced by age and sex. Although alcohol intoxication is increasingly common in adolescents, there are no data on the prevalence of QTc prolongation in adolescents with alcohol intoxication. This study aimed to determine the prevalence of QTc prolongation in adolescents with alcohol intoxication and identify at-risk adolescents. In this observational study including adolescents aged 10–18 years, heart rate and QT interval were automatically assessed from an electrocardiogram (ECG) at alcohol intoxication using a validated algorithm. The QTc was calculated using both the Bazett formula (QTcB) and Fridericia formula (QTcF). If present, an ECG recorded within 1 year of the date of admission to the emergency department was obtained as a reference ECG. A total of 317 adolescents were included; 13.3% had a QTcB and 7.9% a QTcF longer than the sex- and age-specific 95th-percentile. None of the adolescents had a QTcB or QTcF > 500 ms, but 11.8% of the adolescents with a reference ECG had a QTcB prolongation of > 60 ms, while no adolescents had a QTcF prolongation of > 60 ms. QTc prolongation was mainly attributable to an increase in heart rate rather than QT prolongation, which underlies the differences between QTcB and QTcF. Male sex and hypokalaemia increased the likelihood of QTc prolongation.

Conclusion: QTc prolongation was seen in approximately 10% of the adolescents presenting with alcohol intoxication, and although no ventricular arrhythmias were observed in this cohort, QTc prolongation increases the potential for malignant QT-related arrhythmias. Clinicians must be aware of the possibility of QTc prolongation during alcohol intoxication and make an effort to obtain an ECG at presentation, measure the QT interval, and give an adequate assessment of the findings. We advocate admitting adolescents with alcohol intoxication and QTc prolongation. During hospital admission, we recommend limiting exposure to QTc-prolonging medication, increasing potassium levels to a high-normal range (4.5–5.0 mmol/L) and obtaining a reference ECG at discharge.

What is Known:• One out of five deaths in adolescents is alcohol-related. Alcohol intoxication has been related to cardiac arrhythmias and sudden cardiac death.•In adults, alcohol intoxication is associated with QTc prolongation.

What is New:•Approximately 10% of the adolescents with alcohol intoxication had a QTc longer than the age- and sexspecific cut-off. In contrast to adults, in adolescents with alcohol intoxication, QTc prolongation is attributable to an increase in heart rate, rather than a prolongation of the QT interval.•Especially males and adolescents with hypokalaemia are at risk of QTc prolongation.
Lower Bounds from Fitness Levels Made Easy
Authors: Doerr Benjamin , Kötzing Timo
Published: April 2022

One of the first and easy to use techniques for proving run time bounds for evolutionary algorithms is the so-called method of fitness levels by Wegener. It uses a partition of the search space into a sequence of levels which are traversed by the algorithm in increasing order, possibly skipping levels. An easy, but often strong upper bound for the run time can then be derived by adding the reciprocals of the probabilities to leave the levels (or upper bounds for these). Unfortunately, a similarly effective method for proving lower bounds has not yet been established. The strongest such method, proposed by Sudholt (2013), requires a careful choice of the viscosity parameters $$\gamma _{i,j}$$

γ

i
,
j

, $$0 \le i < j \le n$$

0
≤
i
<
j
≤
n

. In this paper we present two new variants of the method, one for upper and one for lower bounds. Besides the level leaving probabilities, they only rely on the probabilities that levels are visited at all. We show that these can be computed or estimated without greater difficulties and apply our method to reprove the following known results in an easy and natural way. (i) The precise run time of the (1+1) EA on LeadingOnes. (ii) A lower bound for the run time of the (1+1) EA on OneMax, tight apart from an O(n) term. (iii) A lower bound for the run time of the (1+1) EA on long k-paths (which differs slightly from the previous result due to a small error in the latter). We also prove a tighter lower bound for the run time of the (1+1) EA on jump functions by showing that, regardless of the jump size, only with probability $$O(2^{-n})$$

O
(

2

-
n

)

the algorithm can avoid to jump over the valley of low fitness.
Modeling Solubility of Anhydrite and Gypsum in Aqueous Solutions: Implications for Swelling of Clay-Sulfate Rocks
Authors: Taherdangkoo Reza , Meng Tao , Amar Menad Nait , Sun Yuantian , Sadighi Ali , Butscher Christoph
Published: April 2022

The swelling of clay-sulfate rocks is a well-known phenomenon often causing threats to the success of various geotechnical projects, including tunneling, road and bridge construction, and geothermal drilling. The origin of clay-sulfate swelling is usually explained by physical swelling due to clay expansion combined with chemical swelling associated with the transformation of anhydrite (CaSO4) into gypsum (CaSO4∙2H2O). The latter occurs through anhydrite dissolution and subsequent gypsum precipitation. Numerical models that simulate rock swelling must consider hydraulic, mechanical, and chemical processes. The simulation of the chemical processes is performed by solving thermodynamic equations, which usually contribute a significant portion of the overall computation time. This paper employs feed-forward neural network (FFNN) and cascade-forward neural network (CFNN) models trained with a Bayesian regularization (BR) algorithm as an alternative approach to determine the solubility of anhydrite and gypsum in the aqueous phase. The network models are developed using calcium sulfate experimental data collected from the literature. Our results indicate that the FFNN-BR is the most accurate model for the regression task. The comparison analysis with the Pitzer ion interaction model as well as previously published data-driven models shows that the FFNN-BR model is highly accurate in determining the solubility of sulfate minerals in acid and salt-containing solutions. We conclude from our results that the FFNN-BR model can be used to determine the solubility of anhydrite and gypsum needed to address typical subsurface engineering problems such as swelling of clay-sulfate rocks.
Filum terminale transection in pediatric tethered cord syndrome: a single center, population-based, cohort study of 95 cases
Authors: Edström Erik , Wesslén Charlotte , Fletcher-Sandersjöö Alexander , Elmi-Terander Adrian , Sandvik Ulrika
Published: April 2022

Purpose

The purpose of this study was to evaluate outcome following surgical transection of filum terminale (FT) in symptomatic and asymptomatic pediatric patients with radiological findings consistent with tethered cord syndrome (TCS).

Methods

Patients < 17 years who underwent untethering surgery between 2007 and 2018 were screened for eligibility. Those who had undergone primary transection of the FT, and had preoperative radiological findings of fatty filum, thickened FT, or low-lying conus, below the pedicles of L2, were included. The cohort was divided into symptomatic and asymptomatic depending on clinical presentation. Surgical complications and functional outcome was recorded.

Results

In total, 95 patients were included, of whom 62 were symptomatic. In symptomatic patients, the main indications for radiological evaluation were scoliosis (29%) and motor symptoms (19%). In asymptomatic patients, skin stigmata (76%) were the most common finding. Fatty or thick FT was the most common radiographic finding, seen in 61% of symptomatic and 79% of asymptomatic cases. All patients underwent transection of the FT and were followed for a median of 1.8 years. A postoperative complication occurred in 12%, all Ibanez type Ib and managed without invasive treatment. For the symptomatic cohort, significant improvement was seen for both urodynamic assessment (48% improved, p = 0.002) and sensorimotor function (42% improved, p < 0.001).

Conclusions

Neurological improvement or halted deterioration was seen in the majority of symptomatic cases. Asymptomatic patients did not experience any severe complications. Filum transection should be offered to symptomatic and asymptomatic patients upon diagnosis of fatty filum, thickened FT, or low-lying conus.
Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: a micro‐computed tomography and positron emission tomography study in rabbits
Authors: Feletto Luigi , Botticelli Daniele , Apaza Alccayhuaman Karol Ali , Peñarrocha-Diago Miguel , Ezzeddin-Ayoub Mustafa , Zaragozi-Alonso Regino , Viña-Almunia Jose
Published: April 2022

Aim

The purpose of this study was to evaluate using microCT and positron emission tomography (PET) analysis, the influence on bone healing of the placement of particulate autogenous bone in the antrostomy, and in the subjacent region after maxillary sinus elevation with xenograft.

Material and methods

The sinus mucosa was elevated in sixteen male New Zealand rabbits and they were both grafted with a collagenated cortico-cancellous porcine bone. The antrostomy and the near subjacent region were filled with either the same xenograft (control site) or with particulate autogenous bone (test site) harvested from the tibia. The antrostomies were covered with collagen membranes. MicroCT (measured in Hounsfield Units) and microPET (kBq/cm3) using sodium fluoride infiltration (18F-NaF) were performed at the time of euthanasia that was performed after 1 and 8 weeks of healing, using 8 animals in each group. The Wilcoxon test was used for analysis.

Results

At the microCT analysis, after 1 and 8 weeks of healing, no statistically significant differences were found between groups. Bone increased and xenograft decreased significantly between the two periods of healing. At the microPET analysis, the percentage of bone increased significantly over time in both test and control groups and no significant differences were found between groups.

Conclusion

The placement of autogenous bone in the antrostomy and the subjacent region after maxillary sinus elevation did not enhance bone formation compared with sites where only xenograft was used. Both microCT and microPET showed increase bone formation over time.
Learning the travelling salesperson problem requires rethinking generalization
Authors: Joshi Chaitanya K. , Cappart Quentin , Rousseau Louis-Martin , Laurent Thomas
Published: April 2022

End-to-end training of neural network solvers for graph combinatorial optimization problems such as the Travelling Salesperson Problem (TSP) have seen a surge of interest recently, but remain intractable and inefficient beyond graphs with few hundreds of nodes. While state-of-the-art learning-driven approaches for TSP perform closely to classical solvers when trained on trivially small sizes, they are unable to generalize the learnt policy to larger instances at practical scales. This work presents an end-to-endneural combinatorial optimizationpipeline that unifies several recent papers in order to identify the inductive biases, model architectures and learning algorithms that promote generalization to instances larger than those seen in training. Our controlled experiments provide the first principled investigation into suchzero-shotgeneralization, revealing that extrapolating beyond training data requires rethinking the neural combinatorial optimization pipeline, from network layers and learning paradigms to evaluation protocols. Additionally, we analyze recent advances in deep learning for routing problems through the lens of our pipeline and provide new directions to stimulate future research.
The evolutionary relationship between bere barley and other types of cultivated barley
Authors: Drosou Konstantina , Craig Hayley , Palmer Karren , Kennedy Sandra L. , Wishart John , Oliveira Hugo R. , Civáň Peter , Martin Peter , Brown Terence A.
Published: April 2022

We used genotyping-by-sequencing to investigate the evolutionary history of bere, the oldest barley variety still cultivated in Britain and possibly in all of Europe. With a panel of 203 wild and 401 cultivated barley accessions, including 35 samples identified as bere, we obtained filtered datasets comprising up to 1,946,469 single nucleotide polymorphisms (SNPs). The beres formed two genetically-distinct groups, the larger of which included beres from Orkney and the Scottish Western Isles, as well as varieties not identified as bere from the Faroe Islands. This group of beres was distinct from other British barleys, but had a close genetic affiliation with Scandinavian accessions. Although the data were partly compatible with the traditional view that bere was introduced to Scotland by the Vikings during the eighth century AD, the evidence as whole suggested that the bere and Scandinavian barleys are sister groups descended from a more distant common progenitor, possibly dating to the Bronze Age when hulled barleys first become common in northern Europe. More recently, there has been gene flow from these beres into Polish barleys, possibly following export of grain to the Baltic region during periods when Orkney was under Norwegian or Danish rule. A second, smaller group of beres, which included a traditional Welsh variety, was genetically distinct from the main group and probably represents a more recent introduction of barley from central Europe. Our results emphasize the uniqueness of bere barley and its importance as a heritage crop and a potential source of germplasm for breeding programmes.
A piecewise constitutive model for collagen fiber tissues
Authors: Ji X. L. , Zhang H. H. , Han S. Y.
Published: April 2022

Inspired by Meyers et al. (Science, 2013), a piecewise model is established so as to individually predict both the heel region and the linear region of stress–strain curve. When the piecewise model satisfactorily predicts the experimental data, the constitutive parameters are precisely identified with definite physical significances. Along with this piecewise guideline, a complete constitutive model can be established for the whole stress–strain curve of collagen fiber tissues with the failure region as well.
Tuning the Properties of Ba-M Hexaferrite BaFe11.5Co0.5O19: A Road Towards Diverse Applications
Authors: Ateia Ebtesam E. , Elsayed Kareem , Ramadan Rania
Published: April 2022

The development of hexaferrite nanoparticles is scrutinized as potential sorbents for the removal of chromium (Cr) ions from aqueous chromium-containing solutions in a batch adsorption experiment. The transition metal Co doped BaFe12O19 hexaferrite compounds (BHF) have been synthesized successfully via citrate auto combustion technique. The structure, surface morphology and magnetic properties of the samples were studied. X-ray diffraction pattern ratifies the existence of hexagonal phase as a main phase for the prepared samples. The average crystallite sizes are found in the range of 47–49 nm. The high-resolution transmission electron microscopy (HRTEM), as well as the Fourier, transform infrared spectrophotometry results confirm an M-type hexagonal structure existing. The χ-T indicates the temperature-dependent ferromagnetic behavior of BHF nanoparticles. The derivative shows a single transition temperature Tc at 698 °C, and 710 °C for BHF and BCHF respectively. The prepared samples are utilized as an adsorbent for the removal of Cr (VI) from the aqueous solution. The maximum adsorption capacity (qm) of Cr (VI) on the nano hexaferrite is higher than that of various other adsorbents testified in the literature. The pseudo-second-order kinetic model gives a better fit to the experimental data.
Peer Victimization, Internalizing Problems, and the Buffering Role of Friendship Quality: Disaggregating Between- and Within-Person Associations
Authors: Bernasco Esther L. , van der Graaff Jolien , Meeus Wim H. J. , Branje Susan
Published: April 2022

Although many studies have shown an association between peer victimization and internalizing problems, which may be buffered by friendship quality, it is unclear whether these associations apply to within-person processes as well. This would mean that at times when adolescents experience more victimization than they usually do, they also experience more internalizing problems. The current study disaggregated between- and within-person variation to examine the association between peer victimization and symptoms of depression and anxiety, and the protective effect of friend support and conflict. Participants were 497 Dutch adolescents (56% boys) with a mean age of 13.03 (SDage = 0.45, ranging from 11.68 to 15.56 at Wave 1). They participated in a 6-wave questionnaire study, with each wave taking place approximately one year after the previous. The results showed that peer victimization was associated with depressive symptoms and anxiety across adolescence, both between and within persons. Friend support buffered this association at the between-person level, but not the within-person level. This study highlights the impact of peer victimization and suggests that friend support may partly protect adolescents from the effects of peer victimization.
Gender stereotypes: implicit threat to performance or boost for motivational aspects in primary school?
Authors: Hermann Johanna Maria , Vollmeyer Regina
Published: April 2022

Based on stereotype threat and stereotype lift theory, this study explores implicit stereotype threat effects of gender stereotypes on the performance of primary school children in mathematics. Moreover, effects of implicit gender stereotypical cues (gender-specific task material) on motivational aspects were explored, which have revealed mixed results in stereotype threat research in the past. N = 151 German primary school children (47.7% female; mean age: M = 9.81, SD = 0.60) calculated either stereotypical or neutral mathematical text problems before motivational aspects were assessed. Contradicting our expectations, results neither revealed a stereotype threat effect on girls’ performance nor a lift effect on the boys. Instead, girls calculating stereotypical tasks outperformed girls in the control group, whereas boys’ performance did not significantly differ compared to the control group. Regarding motivational aspects, only traditional gender differences emerged as girls reported significantly more pressure and tension calculating the mathematical tasks. The discussion focuses on the way in which stereotypes can affect children’s cognitive performance and in turn, their mathematical performance.
Debaryomyces hansenii: an old acquaintance for a fresh start in the era of the green biotechnology
Authors: Navarrete Clara , Estrada Mònica , Martínez José L.
Published: April 2022

The halophilic yeast Debaryomyces hansenii has been studied for several decades, serving as eukaryotic model for understanding salt and osmotic tolerance. Nevertheless, lack of consensus among different studies is found and, sometimes, contradictory information derived from studies performed in very diverse conditions. These two factors hampered its establishment as the key biotechnological player that was called to be in the past decade. On top of that, very limited (often deficient) engineering tools are available for this yeast. Fortunately Debaryomyces is again gaining momentum and recent advances using highly instrumented lab scale bioreactors, together with advanced –omics and HT-robotics, have revealed a new set of interesting results. Those forecast a very promising future for D. hansenii in the era of the so-called green biotechnology. Moreover, novel genetic tools enabling precise gene editing on this yeast are now available. In this review, we highlight the most recent developments, which include the identification of a novel gene implicated in salt tolerance, a newly proposed survival mechanism for D. hansenii at very high salt and limiting nutrient concentrations, and its utilization as production host in biotechnological processes.
The effects of mandibular advancement appliance therapy on the sequence of jaw-closing muscle activity and respiratory events in individuals with obstructive sleep apnea
Authors: Li Deshui , Aarab Ghizlane , Lobbezoo Frank , Arcache Patrick , Lavigne Gilles J. , Huynh Nelly
Published: April 2022

Purpose

To determine the effects of a mandibular advancement appliance (MAA) on sequences of jaw-closing muscle activity (JCMA) and apneic or hypopneic event (AHE) in individuals with obstructive sleep apnea (OSA).

Methods

Individuals with OSA were included in a secondary analysis of a randomized controlled crossover trial, in which two ambulatory polysomnographic recordings were performed: one with MAA in situ and the other without MAA. A time span of 16 s between JCMA and AHE was applied to classify JCMAs into four sequences: (1) JCMA occurs before AHE (B-type); (2) both events occur simultaneously (S-type); (3) JCMA occurs after AHE (A-type); and (4) JCMA is time-unrelated to AHE (U-type). The effects of MAA on the distribution of these sequences were analyzed by Wilcoxon signed-rank test.

Results

Among 16 individuals (10 men, mean age 51.3 ± 8.5 years) baseline apnea–hypopnea index and JCMA index were 23.8 ± 16.0 events/h and 10.8 ± 10.3 events/h, respectively. In both conditions, i.e., without and with MAA, most JCMAs were U-type (48% and 65%, respectively), followed by A-type (41% and 22%), B-type (25% and 21%), and S-type (2% and 1%). With MAA in situ, only the A-type JCMA index decreased significantly (P = 0.005), while B-type, S-type, and U-type JCMA indices did not change significantly (all P > 0.05).

Conclusion

MAA therapy only significantly reduces the jaw-closing muscle activities that occur after apneic or hypopneic events in individuals with OSA.

Trial registration

www.clinicaltrials.gov (NCT02011425); December 13, 2013.
First detection of microplastics in Xyrichtys novacula (Linnaeus 1758) digestive tract from Eivissa Island (Western Mediterranean)
Authors: Cohen-Sánchez Amanda , Solomando Antònia , Pinya Samuel , Tejada Silvia , Valencia José María , Box Antonio , Sureda Antoni
Published: April 2022

Plastic waste and its ubiquity in the oceans represent a growing problem for marine life worldwide. Microplastics (MPs) are ubiquitous in the sea and easily enter food webs. Xyrichtys novacula L. is one of the main target species of recreational fishing in the Balearic Islands, Spain. In the present study, the quantity of MPs in gastrointestinal tracts of X. novacula from two different areas (a marine protected area (MPA) and a non-protected area) of Eivissa Island (in the Balearic archipelago) has been assessed, as well as MPs evaluation within the sediment of both areas. The results showed that over 80% of sampled individuals had MPs in their gut with an average of 3.9 ± 4.3 plastic items/individual. Eighty percent of these plastics were fibres, while the rest were fragments. Although the sediment of the non-protected area had a significant higher presence of MPs, no significant differences in the number of MPs were observed in X. novacula from both areas. The µ-FT-IR analysis showed that the main polymers in the sediments were polycarbonate (PC) and polypropylene (PP), whereas in the digestive tract of fish PC, PP, polyethylene, polystyrene and polyester. In conclusion, practically all X. novacula specimens presented MPs in their digestive tract regardless if the capture zone was in a MPAs or not. These results highlight the ubiquity of MPs in coastal marine areas, and further studies might be necessary to evaluate further implications of MP presence in this species.
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
Authors: Bruno Maria E. C. , Mukherjee Sujata , Powell Whitney L. , Mori Stephanie F. , Wallace Franklyn K. , Balasuriya Beverly K. , Su Leon C. , Stromberg Arnold J. , Cohen Donald A. , Starr Marlene E.
Published: April 2022

Adipose tissue dysfunction is strongly linked to the development of chronic inflammation and cardiometabolic disorders in aging. While much attention has been given to the role of resident adipose tissue immune cells in the disruption of homeostasis in obesity, age-specific effects remain understudied. Here, we identified and characterized a population of γδ T cells, which show unique age-dependent accumulation in the visceral adipose tissue (VAT) of both mice and humans. Diet-induced obesity likewise increased γδ T cell numbers; however, the effect was greater in the aged where the increase was independent of fat mass. γδ T cells in VAT express a tissue-resident memory T cell phenotype (CD44hiCD62LlowCD69+) and are predominantly IL-17A-producing cells. Transcriptome analyses of immunomagnetically purified γδ T cells identified significant age-associated differences in expression of genes related to inflammation, immune cell composition, and adipocyte differentiation, suggesting age-dependent qualitative changes in addition to the quantitative increase. Genetic deficiency of γδ T cells in old age improved the metabolic phenotype, characterized by increased respiratory exchange ratio, and lowered levels of IL-6 both systemically and locally in VAT. Decreased IL-6 was predominantly due to reduced production by non-immune stromal cells, primarily preadipocytes, and adipose-derived stem cells. Collectively, these findings suggest that an age-dependent increase of tissue-resident γδ T cells in VAT contributes to local and systemic chronic inflammation and metabolic dysfunction in aging.
Experimental Study of the Cu2O-FeOx-CaO System in Equilibrium With Metallic Copper at 1200 °C to 1300 °C and at P(O2)s = 10−5 to 10−7 Atm
Authors: Sineva Svetlana , Shishin Denis , Starykh Roman , Shevchenko Maksym , Jak Evgueni
Published: April 2022

The experimental study of the phase equilibria between calcium ferrite slag, metallic copper, spinel and/or dicalcium ferrite in the Cu2O-FeO
x
-CaO system has been carried out. Effects of temperature, oxygen partial pressure and Fe/CaO ratio on phase assemblages and compositions have been estimated. The advanced experimental technique including high-temperature equilibration on primary phase substrates, rapid quenching of the samples and quantitative measurements of equilibrated phase compositions using electron probe X-ray microanalysis has been applied. Spinel and dicalcium ferrite substrates have been specially designed to study phase equilibria at certain primary phase fields. Obtained experimental results have been compared with thermodynamic assessment of the Cu2O-FeO
x
-CaO system and available literature data.
Does a Low Amount of Substituents Improve the Thermoelectric Properties of Cr2−xMxS3 (M = Ti, V, Sn)?
Authors: Groß Hendrik , Ekici Yeliz , Poschmann Michael , Groeneveld Dennis , Dankwort Torben , Koenig Jan D. , Bensch Wolfgang , Kienle Lorenz
Published: April 2022

The effects of low-level partial cation substitution in Cr2−xMxS3 with M = Ti, V or Sn and x = 0.05 and 0.1 have been investigated regarding the long- and short-range crystal structures and thermoelectric properties. All substituted compounds crystallized in the equilibrium phase of Cr2S3, adopting the space group R$${\overline{\text{3}}}$$

3
¯

. Electron beam irradiation led to a phase transformation from space group R$${\overline{\text{3}}}$$

3
¯

to P$${\overline{\text{3}}}$$

3
¯

1c with a subsequent appearance of diffuse scattering, indicating short-range ordering of cations in the partially occupied cation layers. Substitution of Cr by V led to a reduction in electrical conductivity and subsequently to a lower thermoelectric performance in comparison to the pristine material. In contrast, substitution with Ti yielded an improvement of the performance due to a higher electrical conductivity and a reasonably high Seebeck coefficient. Both Sn-substituted compounds contained only traces of Sn. Surprisingly, a significant improvement of the electrical conductivities could be observed in comparison to the pristine material as well as the other Cr2−xMxS3 materials.
A review of the effects of forest fire on soil properties
Authors: Agbeshie Alex Amerh , Abugre Simon , Atta-Darkwa Thomas , Awuah Richard
Published: April 2022

Forest fires are key ecosystem modifiers affecting the biological, chemical, and physical attributes of forest soils. The extent of soil disturbance by fire is largely dependent on fire intensity, duration and recurrence, fuel load, and soil characteristics. The impact on soil properties is intricate, yielding different results based on these factors. This paper reviews research investigating the effects of wildfire and prescribed fire on the biological and physico-chemical attributes of forest soils and provides a summary of current knowledge associated with the benefits and disadvantages of such fires. Low-intensity fires with ash deposition on soil surfaces cause changes in soil chemistry, including increase in available nutrients and pH. High intensity fires are noted for the complete combustion of organic matter and result in severe negative impacts on forest soils. High intensity fires result in nutrient volatilization, the break down in soil aggregate stability, an increase soil bulk density, an increase in the hydrophobicity of soil particles leading to decreased water infiltration with increased erosion and destroy soil biota. High soil heating (> 120 °C) from high-intensity forest fires is detrimental to the soil ecosystem, especially its physical and biological properties. In this regard, the use of prescribed burning as a management tool to reduce the fuel load is highly recommended due to its low intensity and limited soil heating. Furthermore, the use of prescribed fires to manage fuel loads is critically needed in the light of current global warming as it will help prevent increased wildfire incidences. This review provides information on the impact of forest fires on soil properties, a key feature in the maintenance of healthy ecosystems. In addition, the review should prompt comprehensive soil and forest management regimes to limit soil disturbance and restore fire-disturbed soil ecosystems.
Where Are We Now and Where Might We Be Headed in Understanding and Managing Brain Metastases in Colorectal Cancer Patients?
Authors: Mjahed Ribal Bou , Astaras Christoforos , Roth Arnaud , Koessler Thibaud
Published: April 2022

Opinion statement

Compared to liver and lung metastases, brain metastases (BMs) from colorectal cancer (CRC) are rare and remain poorly investigated despite the anticipated rise in their incidence. CRC patients bearing BM have a dismal prognosis with a median survival of 3–6 months, significantly lower than that of patients with BM from other primary tumors, and of those with metastatic CRC manifesting extracranially. While liver and lung metastases from CRC have more codified treatment strategies, there is no consensus regarding the treatment of BM in CRC, and their management follows the approaches of BM from other solid tumors. Therapeutic strategies are driven by the number and localisation of the lesion, consisting in local treatments such as surgery, stereotactic radiosurgery, or whole-brain radiotherapy. Novel treatment modalities are slowly finding their way into this shy unconsented armatorium including immunotherapy, monoclonal antibodies, tyrosine kinase inhibitors, or a combination of those, among others.

This article reviews the pioneering strategies aiming at understanding, diagnosing, and managing this disease, and discusses future directions, challenges, and potential innovations in each of these domains.

Highlights

• With the increasing survival in CRC, brain and other rare/late-onset metastases are rising.

• Distal colon/rectal primary location, long-standing progressive lung metastases, and longer survival are risk factors for BM development in CRC.

• Late diagnosis and lack of consensus treatment strategies make BM-CRC diagnosis very dismal.

• Liquid biopsies using circulating tumor cells might offer excellent opportunities in the early diagnosis of BM-CRC and the search for therapeutic options.

• Multi-modality treatment including surgical metastatic resection, postoperative SRS with/without WBRT, and chemotherapy is the best current treatment option.

• Recent mid-sized clinical trials, case reports, and preclinical models show the potential of unconventional therapeutic approaches as monoclonal antibodies, targeted therapies, and immunotherapy.
Effects of an enteral nutrient-rich therapy with omega-3 fatty acids in patients with unresectable or recurrent biliary tract cancer or pancreatic cancer during chemotherapy: a case–control study
Authors: Abe Kyohei , Uwagawa Tadashi , Hamura Ryoga , Shirai Yoshihiro , Yasuda Jungo , Furukawa Kenei , Shiozaki Hironori , Onda Shinji , Gocho Takeshi , Ikegami Toru
Published: April 2022

To evaluate omega-3 fatty acid-rich enteral nutrient effects in patients with unresectable or recurrent biliary tract or pancreatic cancers during chemotherapy. Enteric nutritional supplements containing omega-3 fatty acids (Racol®) was administered to aforementioned patients with cancers during chemotherapy. The skeletal muscle mass and blood test data were obtained pre-administration and 28 and 56 days after. Patients with pancreatic cancer were administered the digestive enzyme supplement pancrelipase (LipaCreon®) 28 days after the start of Racol® administration. The number of chemotherapies skipped due to neutropenia was recorded for 2 months before and after enteral nutrient initiation. In all 39 patients, the skeletal muscle mass increased on day 56 versus baseline (median 17.3 kg vs. 14.8 kg, p < 0.01), number of chemotherapies skipped decreased (mean: 0.65 times/month vs. 1.3 times/month, p = 0.03), and retinol-binding protein (mean: 2.56 mg/dL vs. 2.42 mg/dL, p = 0.05) increased. Patients with pancreatic cancer showed increased blood eicosapentaenoic acid concentration on day 56 versus baseline (median: 48.1 μg/mL vs. 37.0 μg/mL, p = 0.04) and increased skeletal muscle mass (median 16.8 kg vs. 14.4 kg, p = 0.006). Baseline median neutrophil count increased significantly from 2200/μL at baseline to 2500/μL (p = 0.04). Patients with biliary tract cancer during chemotherapy also exhibited increased skeletal muscle mass following omega-3 supplementation (median 17.3 kg vs. 15.8 kg, p = 0.01). In patients undergoing chemotherapy for unresectable or post-recurrence pancreatic and biliary tract cancers, high-omega-3 fatty acid nutrition therapy use improved skeletal muscle maintenance and chemotherapy dosing intensity.
Mutation in SF3B1 gene promotes formation of polyploid giant cells in Leukemia cells
Authors: Mukherjee Sanjay , Ali Abdullah Mahmood , Murty Vundavalli V. , Raza Azra
Published: April 2022

Giant cells with polyploidy, termed polyploid giant cells, have been observed during normal growth, development, and pathologic states, such as solid cancer progression and resistance to therapy. Functional studies of polyploidal giant cancer cells (PGCC) provided evidence that they arise when normal diploid cells are stressed, show stem cell-like properties, and give rise to tumors. In the present study, we report in K562 leukemia cell line that introduction of the hotspot K700E mutation in the gene SF3B1 using CRISPR/Cas9 method results in an increased frequency of multinucleated polyploid giant cells resistant to chemotherapeutic agent and serum starvation stress. These giant cells with higher ploidy are distinct from multinucleated megakaryocytes, are proliferative, and are characterized by increased accumulation of mitochondria. PGCC have been previously documented in solid tumors. This is the first report describing PGCCs in a cell line derived from a liquid cancer where increased frequency of PGCCs is linked to a specific genetic event. Since SF3B1 mutations are predominantly seen in MDS and other hematologic malignancies, our current findings will have significant clinical implications.