bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating Management Implications of the New York Phosphorus Index with Farm Field Information
Authors: Ros Mart B. H. , Ketterings Quirine M. , Cela Sebastian , Czymmek Karl J.
Published: June 2019

Phosphorus (P) loss from agricultural fields can contribute to water quality degradation. The current New York P index (NY‐PI) scores fields on the basis of P sources and field characteristics that reflect risk of P transport (a source × transport approach). Recently, a transport × best management practice (BMP) approach was proposed, which first scores fields using landscape‐driven transport factors and then offers various BMPs to reduce the score (i.e., risk of P transport). To analyze the score distribution of the current NY‐PI and the incentivizing potential of the proposed structure, a database of 33,327 agricultural fields in New York was assembled in collaboration with nutrient management planners and farmers. Under the current NY‐PI, no additional P could be applied to 2% of the fields, while for 3% the application rates should not exceed annual crop P removal. Flow distance (field to stream) was a major driver for NY‐PI scores. The current NY‐PI relies heavily on soil test P to assess runoff risk, allowing some low‐P fields to receive manure independent of transport risk. A scenario evaluation showed that the proposed NY‐PI limits P application on fields with high transport risk while simultaneously incentivizing adoption of BMPs in such areas. In the absence of farm‐level water quality data, a farm field database can help set P index coefficients and assess implications of a new P index. This study emphasizes the value of involving stakeholders in assessing nutrient management tools, as well as the importance of using an incentive‐driven approach for protecting water resources.

Core Ideas

Phosphorus indices (PIs) rank farm fields by relative P loss risk.

Evaluation and revision of PIs is essential to improve P management over time.

Nutrient management planning in New York requires PI evaluation of each field.

Management implications of PIs can be analyzed with a database of fields.

Scenario analysis with field information can help set PI coefficients.
Impacts of Cover Crops and Crop Residues on Phosphorus Losses in Cold Climates: A Review
Authors: Liu Jian , Macrae Merrin L. , Elliott Jane A. , Baulch Helen M. , Wilson Henry F. , Kleinman Peter J.A.
Published: June 2019

The use of cover crops and crop residues is a common strategy to mitigate sediment and nutrient losses from land to water. In cold climates, elevated dissolved P losses can occur associated with freeze–thaw of plant materials. Here, we review the impacts of cover crops and crop residues on dissolved P and total P loss in cold climates across ∼41 studies, exploring linkages between water‐extractable P (WEP) in plant materials and P loss in surface runoff and subsurface drainage. Water‐extractable P concentrations are influenced by plant type and freezing regimes. For example, WEP was greater in brassica cover crops than in non‐brassicas, and increased with repeated freeze–thaw cycles. However, total P losses in surface runoff and subsurface drainage from cropped fields under cold climates were much lower than plant WEP, owing to retention of 45 to >99% of released P by soil. In cold climatic regions, cover crops and crop residues generally prevented soil erosion and loss of particle‐bound P during nongrowing seasons in erodible landscapes but tended to elevate dissolved P loss in nonerodible soils. Their impact on total P loss was inconsistent across studies and complicated by soil, climate, and management factors. More research is needed to understand interactions between these factors and plant type that influence P loss, and to improve the assessment of crop contributions to P loss in field settings in cold climates. Further, tradeoffs between P loss and the control of sediment loss and N leaching by plants should be acknowledged.

Core Ideas

Winter crop covers reduce soil erosion but may enhance dissolved P loss under cold climates.

In cold climates, freeze–thaw cycles increase dissolved P release from plants and soils.

Plant water‐extractable P varies with crop species, hardiness, and freeze regimes.

Phosphorus losses in runoff and leaching are complicated by soil, hydrology, and management.

Assessment of crop impacts on P loss should consider tradeoffs and future climates.
Steady Water Flow with Interacting Point Source–Point Sink–Water Table in a Cylindrical Soil Domain
Authors: Friedman Shmulik P. , Gamliel Alon
Published: June 2019

Core Ideas

Simultaneous root water uptake from a surface emitter and from groundwater is evaluated.

The source–sink–water table problem is decoupled into source–sink and sink–water table problems.

Water uptake from the surface emitter is larger in the presence of a shallow water table.

Water uptake from a shallow water table is smaller if applying supplementary irrigation.

A previously derived analytical solution to the quasi‐linear form of the water flow equation is used to analyze (i) steady, coupled plant water uptake from a surface water emitter in a confined cylindrical soil domain with a non‐evaporating surface in the presence of a shallow water table, and (ii) water uptake from only the water table in the absence of a surface emitter. Illustrative examples serve to analyze and discuss water‐uptake rates of a subsurface, spherical, conceived root zone and the complex water‐flow patterns occurring in either natural fields with shallow groundwater or artificial lysimeters. The coupled source–sink–water table model is also used to illustrate the dependence of the contributions of surface emitter and water table to the overall water‐uptake rate on capillary length and hydraulic conductivity of the saturated soil, the depth of the water table and its prescribed pressure head, the depth and size of the root zone, and the radius of the confined cylinder, representing the effect of neighboring plants and emitters. The proposed methodology can be used to evaluate the effects of these factors on the potential utilization of shallow groundwater, as well as in cases with a supplementary drip irrigation system, and to support design decisions concerning the distance between emitters (and between plants) and the irrigation rates required to complement plant water uptake from groundwater.
EDUCAÇÃO A DISTÂNCIA: INTERFACES MOTIVACIONAIS E REFLEXIVAS DAS AÇÕES DE FORMAÇÃO CONTINUADA
Authors: Saggiomo Leandro Da Silva , Pereira Elaine Corrêa
Published: June 2019

A fim de qualificar o corpo docente que atua nos cursos nessa modalidade Educação a Distância (EaD) oferecidos pela Universidade Federal do Rio Grande – FURG, a Secretaria de Educação a Distância (SEaD) desenvolve ações de formação continuada para os sujeitos que atuam nestes cursos. Inseridos nesse contexto encontramos os tutores a distância, responsáveis pelo desenvolvimento, acompanhamento e avaliação dos estudantes. A presente pesquisa de cunho qualitativo visa identificar as percepções dos tutores a distancia do curso de graduação em administração modalidade EaD sobre as motivações e reflexões geradas pela participação em atividades de formação continuada. Os pesquisados são tutores a distância que atuaram em duas edições do curso de Administração modalidade a distância. Os dados foram coletados por meio de entrevista semiestruturada e analisados pelo método denominado Discurso do Sujeito Coletivo, proposto por Lefèvree Lefèvre (2012), o qual se fundamenta a partir da teoria da Representação Social, permitindo desvelar os pensamentos, representações, valores e crenças de uma coletividade. A partir das análises foi gerado o Discurso Coletivizado intitulado “As Ações de Formação em EaD e as Percepções do Tutor a Distância"”, que embasaram algumas reflexões, demonstrando a análise critica dos sujeitos investigados sobre o processo de formação continuada da SEaD.Palavras-chave: Formação Continuada, Educação a Distância, Tutor a Distância.
Alergia ao látex no perioperatório de cirurgia bariátrica
Authors: Guimarães Mariana Suéte , Almeida Marques Louisie Marcelle da Silva , Carraretto Antonio Roberto , Brocco Marcos Célio , De Almeida Carlos Eduardo David
Published: June 2019

Latex allergy in the perioperative period of bariatric surgery
Análise das ações educativas sobre a saúde auditiva em crianças escolares
Authors: Dias Ana Cristina , Siqueira Luciana Pillon , Viganó Camila
Published: June 2019

Analysis of educative actions concerning the hearing health of school children
Percepção de profissionais de enfermagem acerca dos riscos ocupacionais
Authors: De Oliveira Santos Viviane , Toscano de Campos Monica Chiodi
Published: June 2019

Perception of nursing professionals about occupational hazards
Hemocultura em Unidade de Terapia Intensiva: prevalência, perfil de solicitações e susceptibilidade microbiana em um hospital do Sudoeste da Bahia
Authors: Fernandes Damares Dias , Rocha Ramos Ludimila , Vasconcelos Oliveira Márcio , Souza Cláudio Lima
Published: June 2019

Blood culture in Intensive Care Units: prevalence, request profile and microbial susceptibility in a hospital in Southwestern Bahia state, Brazil
Exposição a adversidades na infância e tabagismo
Authors: Araújo Faria Ana Paula , Bergami Lima Carlos Augusto , Molina Maria Del Carmen , Pereira Flavia Garcia , Freire Coutinho Evandro Silva , Viana Maria Carmen
Published: June 2019

Exposure to adversities in childhood and tobacco use
Ansiedade, depressão e qualidade do sono no pós-operatório mediato de cirurgia oncológica
Authors: Barbosa Larice Kelle , Cordeiro Silva Jéssica Suguri , Monteiro de Almeida Aline Cristiane , Almeida Leroy Patrícia Luz , Brom Vieira Martina Estevam
Published: June 2019

Anxiety, depression and sleep quality in mediate postoperative oncologic surgery
Prematuridade ao nascer, hipertensão materna e outros fatores associados: um estudo de caso-controle na região do Vale do São Francisco
Authors: Da Cruz Simone Seixas , Santana Costa Victoria , Da Mata Santos Juliana Macedo , Oliveira Gomes Thiago Alexander , Ribeiro Brandão Isabella Tainã , Araújo Fonseca Carlos Henrique , Lessa Vilasboas Saulo Wesley Silva , Borges Silva Roberta , Gomes-Filho Isaac Suzart , Maria Souza Luise , Godoy Figueireido Ana Claudia Morais , Batista Josicélia Tuy
Published: June 2019

Prematurity at birth, maternal hypertension and other associated factors: a case-control study conducted in Vale do São Francisco region, Brazil
Comissões de Integração Ensino-Serviço: (des)montando os quebra-cabeças da Educação Permanente
Authors: Da Silva Thiago Fachetti , Duarte Lima Rita de Cássia , Pinheiro Garcia Ana Cláudia , Carvalho Andrade Maria Angélica , França da Silva Tania Cristina
Published: June 2019

Teaching-Service Integration Committees: (dis)assembling the Permanent Education jigsaw puzzle
Chemical Composition and Nutritional Analysis of Seeds Cactus (Opuntia ficus-indica.L)
Authors: Benattia Farah K. , Arrar Zoheir , Dergal Fayçal
Published: June 2019

Background:

The Prickly pear "Opuntia ficus-indica" is a xerophytic plant of the Cactaceae family, which represents a gold mine, can be exploited in several sectors.

Objective:

The present study describes and provides basic information on the physico-chemical properties, mineral and lipid compositions of the cactus seeds from Algeria (Relizane), in order to evaluate the nutritional value of the Opuntia extracts.

Methods:

The seed oil was extracted by soxhlet, and analyzed by GC-MS the physical properties were determined using standard methods of Association of Analytical Communities (AOAC).

Results:

The cactus powder and its seeds showed a content of 6.42% in lipids and 91.24% in ashes. Freshly extracted oil showed acid and peroxide values respectively 2.66 mg (KOH)g and 1.5Meq (O2)/Kg. Iodine and saponification values were 199.5 g (I2)/100 g and 181.44 mg (KOH)/g respectively. Main fatty acids identified by GC-MS were linoleic (C18:2), oleic (C18:1), palmitic (C16:0), palmitoleic (C16:1) and stearic (C18:0) acids with respective contents 60.23%, 13.35%, 14.20%, 1.05 and 3.12%. Mineral analysis revealed significant levels of calcium and potassium namely 72 and 3.50mg/100g respectively, and they contain no trace of the toxic compounds (lead and cadmium).

Conclusion:

The nopal fruit represents a very important nutritional value. This plant is far from being a simple cactus, it is a source of immense wealth.
Factors Predisposing to Hypertension in Subjects Formerly Born Preterm: Renal Impairment, Arterial Stiffness, Endothelial Dysfunction or Something Else?
Authors: Crisafulli Antonio , Bassareo Pier P. , Kelleher Sean , Calcaterra Giuseppe , Mercuro Giuseppe
Published: June 2019

:

Subjects formerly born preterm subsequently develop arterial - particularly isolated systolic-
hypertension more frequently than their peers born at term.

:

Numerous factors may influence this predisposition, including an incomplete nephrogenesis, implying
the presence of kidneys with a reduced number of nephrons and consequent reduction in haematic
filtration, increased sodium absorption and activation of renin-angiotensin-aldosterone system,
increased arterial rigidity produced by an elastin deficiency previously observed in anatomic
specimens of human immature aorta, and reduced endothelial nitric oxide excretion, due to high
blood levels of ADMA, a strong direct inhibitor of nitric oxide that exerts a vasoconstrictor effect.

:

Other possible factors (i.e. excretion of neuroendocrine compounds) may also be implicated. The
aim of this paper was to review all possible mechanisms involved in the observed increase in blood
pressure in individuals who had been born preterm and/or with intrauterine growth restriction. The
outlook for new and promising laboratory techniques capable of identifying alterations in the metabolic
pathways regulating blood pressure levels, such as metabolomics, is also provided.
Antiviral Drugs and Acute Kidney Injury (AKI)
Authors: Leowattana Wattana
Published: June 2019

The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as cidofovir, adefovir and tenofovir with unique effects on transporter defects, apoptosis, and mitochondrial injury. AIN from atazanavir is a rapid onset of AKI and usually nonoliguric but dialytic therapy are needed because of severity. Additionally, crystal nephropathy from acyclovir, indinavir, and foscarnet can cause AKI due to intratubular obstruction. In this article, the mechanisms of antiviral drug-induced AKI were reviewed and strategies for preventing AKI were mentioned.
Development of an Efficient, Non-Invasive Method for Cardiovascular Disease Risk Stratification in a Resource-Limited Setting
Authors: Pramanik Biswarup , Ghosh Amit
Published: June 2019

Background:

Augmentation Index (AIx) is considered as an important predictor of cardiovascular
disease. So, quantification of AIx may provide a rapid cost-effective and non-invasive
means of cardiovascular risk stratification. At present, WHO/ISH risk prediction charts are used to
predict 10-year risk of a fatal or nonfatal major cardiovascular event, an assessment which requires
laboratory support for blood chemistry and thus making it ill-suited for resource-limited settings.

Objectives:

In this study, we examined the association of AIx with cardiovascular risk as determined
by the WHO/ISH chart and identified AIx cut-offs to stratify patients into different risk categories.

Methods:

A case-control study with 162 cases and 61 controls was conducted in a tertiary care
hospital in eastern India. Data were obtained for demographic, anthropometric, cardiovascular, and
biochemical parameters. Cardiovascular risk assessment was carried out by WHO/ISH risk model
in R. Statistical analysis was done for examining the association of AIx with WHO/ISH cardiovascular
risk and for identifying AIx cut-offs to stratify patients into different risk categories.

Results:

Box and whisker plots for assessing the correlation between AIx and WHO/ISH cardiovascular
risk showed an increase in the median value of AIx with increasing risk in both cases and
controls. Heart rate corrected AIx showed a steady increase with increasing risk in males. AIx cutoffs
showed good sensitivity and specificity for each risk category.

Conclusions:

AIx is remarkably associated with cardiovascular risk as assessed by the WHO/ISH
chart and the AIx cut-offs obtained in the study can be used as an efficient, non-invasive surrogate
biomarker of cardiovascular risk even in resource-limited settings.
Receptor-Independent Metabolic Effects of Thiazolidinediones in Astrocytes
Authors: Akar Candan , Kalinin Sergey , Gavrilyuk Vitaliy , Spagnolo Alessandra , Weinberg Guy , L Feinstein Douglas
Published: June 2019

Thiazodinedione (TZD) agonists of the peroxisome proliferator activated receptor gamma (PPAR􀀃) exert metabolic effects in glial cells. In primary astrocytes, TZDs are cytoprotective and have anti-inflammatory actions; in contrast, in glioma cells TZDs are cytotoxic. Although PPAR􀀃 is considered their primary target, TZDs including pioglitazone and troglitazone also bind to a mitochondrial protein MitoNEET; whether their metabolic effects are mediated by activation of PPAR􀀃 or MitoNEET are not known. We generated PPAR􀀃 null astrocytes by crossing a PPAR􀀃 floxxed mouse with a transgenic line expressing CRE recombinase under control of the GFAP promoter. PPAR􀀃 deficient astrocytes showed reduced lactate production under basal conditions and in response to pioglitazone; however at later times similar levels of lactate were produced. In the presence of troglitazone lactate production was similar in PPAR􀀃 null cells as wildtype astrocytes.
In astrocytes in which MitoNEET expression was reduced using siRNA, basal lactate production was lower than control cells, however the cells increased lactate production in response to TZDs. When MitoNEET was decreased in the PPAR􀀃 null astrocytes, responses to TZDs were reduced compared to non-infected cells. These results indicate that metabolic effects of TZDs are not exclusively mediated via PPAR􀀃, but involve binding to MitoNEET. Real time PCR revealed significantly greater MitoNEET mRNA in glioma cells than astrocytes. Differences in MitoNEET expression or activity could therefore contribute to differential effects of TZDs on astrocyte versus glioma cells.
Immunotherapy Targeted at Brain Cancer Stem Cells
Authors: Toda Masahiro
Published: June 2019

Progress in stem cell research has been associated with the discovery of the presence of cancer stem cells in a variety of malignant tumors, and because these cells are resistant to anticancer agents and radiotherapy, analysis of their properties has been rapidly pursued as an important target for the treatment of cancers, including malignant brain tumors. Brain cancer stem cells (BCSCs) have been isolated from brain tumor tissue and brain tumor cell lines by using neural
stem cell culture methods. Analyzing the properties of BCSCs is extremely important to developing treatment methods that target BCSCs. Although no treatment method targeting BCSCs has yet been established, several methods have been proposed based on their cell-biological characteristics. This article describes therapeutic strategies that target drug-resistance molecules and stem-cell-associated molecules as well as immunotherapy targeted at BCSCs.
Formulation Development, Statistical Optimization and Characterization of the Self-Microemulsifying Drug Delivery System (SMEDDS) of Irbesartan
Authors: Swain Suryakanta , Beg Sarwar , Sahu Prafulla K. , Jena Bikash R. , Babu Sitty M.
Published: June 2019

Background:

Irbesartan is an anti-hypertensive BCS class II drug exhibiting poor aqueous
solubility, which makes it highly challenging for delivery through the oral route. Based on this fact, a
self-microemulsifying drug delivery system (SMEDDS) was designed and characterized for augmenting
the aqueous solubility and dissolution rate of irbesartan.

Methods:

Several blends of oil (Capmul MCM EP), surfactant (Tween 80) and co-surfactant (PEG 600)
were screened from the preliminary solubility and pseudo-ternary phase diagram studies. Systematic optimization
of the SMEDDS was carried out using 3-factor 3-level Box-Behnken design.

Results:

The optimized formulation was identified by numerical optimization technique, which revealed
faster emulsification time, high percent transmittance and drug content, lower globule size < 100 nm,
zeta potential and excellent thermodynamic stability. The optimal formulation unveiled more than
93.3% drug release in vitro within 60 minutes, while the pure drug exhibited only 20% drug release, respectively.

Conclusion:

Ex vivo permeability and in situ intestinal absorption of drugs was improved nearly 2 to 3-
fold by the optimal SMEDDS formulation against the pure drug alone (p < 0.001). Overall, the proposed
SMEDDS formulation of irbesartan exhibited a superior biopharmaceutical performance.
Improving Scalability, Sparsity and Cold Start User Issues in Collaborative Tagging with Incremental Clustering and Trust
Authors: Banda Latha , Singh Karan
Published: June 2019

Background:

Due to huge data in web sites, recommending users for every product is impossible.
For this problem Recommender Systems (RS) are introduced. RS is categorized into Content-Based (CB),
collaborative Filtering (CF) and Hybrid RS. Based on these techniques recommendations are done to user.
In this, CF is the recent technique used in RS in which tagging feature also provided.

Objective:

Three main issues occur in RS are scalability problem which occurs when there is a huge data,
sparsity problem occurs when rating data is missing and cols start user or item problem occurs when new
user or new item enters in the system. To avoid these issues here we have proposed Incremental clustering
and Trust in Collaborative Tagging.

Methods:

Here we have proposed a method Collaborative Tagging (CT) with Incremental Clustering and
Trust which enhances the recommendation quality by removing the issues of scalability with the help of Incremental
Clustering and sparsity and cold start user or item problems are resolved with the help of Trust.

Results:

Here we have compared the results of Collaborative tagging with Incremental Clustering and Trust
(CFT-EDIC-TS) with the baseline approaches of CT with Cosine similarity (CFT-CS), CT with Euclidian
Distance and Incremental Clustering (CFT-EDIC) and CT with Trust (CFT-TS).

Conclusion:

Here we have compare the proposed approach with the baseline approaches and the metrics are
used MAE, prediction percentage, Precision and Recall. Based on these metrics for every split CFT-EDICTS
shown best results as compared to other baseline approaches.
ВПЛИВ ЛАКТУЛЬОЗИ НА СТАН МІКРОБІОТИ ТОВСТОЇ КИШКИ ТА ЛІПІДНИЙ СПЕКТР КРОВІ У ХВОРИХ НА СИНДРОМ ПОДРАЗНЕНОЇ КИШКИ У ПОЄДНАННІ З ОЖИРІННЯМ
Authors: Григорук Г. В.
Published: June 2019

Згідно Римських критеріїв IV синдром подразненої кишки визначають як хронічний функціональний розлад кишечника, що характеризується рецидивуючим абдомінальним болем, який виникає і продовжується не менше як один раз на тиждень за останні три місяці, звязаний з  дефекацією, змінами частоти і консистенції стільця. Синдром подразненої кишки відрізняється від інших функціональних розладів, зокрема функціонального закрепу, наявністю болевого синдрому, а від функціонального здуття кишечника, зміною характеру стільця та больового синдрому. Істотними факторами ризику розвитку СПК, окрім недостатньої кількості клітковини в раціоні, стресів, запалення, генетичної схильності є ожиріння та високий індекс маси тіла.
НУТРІЦІЙНА ПIДТРИМКА ПРИ ОПЕРАЦІЯХ НА ПІДШЛУНКОВІЙ ЗАЛОЗІ
Authors: Костюченко Л. М. , Кузьмiна Т. М. , Дубцова О. А. , Микільська К. А. , Костюченко М. В. , Личкова А. Е.
Published: June 2019

Актуальність. Вiдомо, що нутрицiйна підтримка (НП) сприятливо впливає на результат хірургічного лікування і процеси відновлення після ХТ. Однак до теперішнього часу роль нутрицiолога не достатньо враховується.

Мета: оцінити роль нутрицiолога у міждисциплінарному підходi до лікування пацієнтів з пухлиною пiдшлункової залози (ПЗ), а також значення ад'ювантної нутриційної підтримки у структурі комбінованого лікування.

Матеріали і методи. 35 пацієнтів з внутрішньопротоковою аденокарцiномою (5 осіб з Т1N0M0, 7 – з Т2N0M0, 14 – з метастатичною пухлиною ПЗ Т3N0М1, 3 – з Т4N1M1 і 6 – з непідтвердженим по стадіях раком). Нутрицiйний ризик (НР) оцінювали за шкалою NRI, якість життя -SF-36 і ECOG, склад тіла – за допомогою бiоiмпедансного методу. Статистичний метод – Statistics 12.

Результати. При вивченні механізмів м'язового катаболізму, параметрів основного обміну і фазового кута відзначено, що у пацієнтів з високим НР знижувалися як худа (ХМТ), так і жирова маса тіла при підвищеному вмісті позаклітинної рідини. Після ад'ювантної НП у пацієнтів з Т1N0M0, T2N0M0 довго вдавалося зберігати ХМТ у межах фітнес-стандарту, що супроводжувалося позитивною динамікою біохімічних параметрів, тенденцією до нормалізації фазового кута. Якість життя при НП у всіх пацієнтів була вищою, а НР нижчою.

Висновоки. Якість життя забезпечується не тільки базовим оперативним лікуванням, але і своєчасним купіруванням метаболічних (у тому числі нутрицiйних) ускладнень онкопроцесу. При комбінованому лікуванні оперованої пухлини ПЗ роль хірурга-нутрицiолога є важливою, оскільки НП (включаючи детоксикаційне харчування) ефективна.
РОЛЬ ТРОМБОЕЛАСТОГРАФІЇ У КОНТРОЛІ ПРОФІЛАКТИЧНОГО ЛІКУВАННЯ ХВОРИХ НА ТЯЖКУ ФОРМУ ГЕМОФІЛІЇ А БЕЗ ІНГІБІТОРІВ
Authors: Красівська В. В. , Стасишин О. В. , Семерак М. М. , Тушницький О. М.
Published: June 2019

Резюме.  На основі вивчення показників ТЕГ та традиційних тестів дослідження гемостазу удосконалити лабораторний моніторинг профілактичного лікування препаратами концентратів факторів у хворих на гемофілію А. Матеріали і методи. Дослідження виконано у 9 хворих на тяжку форму гемофілії А без інгібіторів, профілактична доза лікування яких становила 45±5 МО/кг ФVIII 2 рази на тиждень. Визначення проводили на плановому візиті у тесті відновлення (ТВ) (доза 60±5 МО/кг). Аналізували показники ТЕГ у комплексі із показниками гемостазу, активністю ФVIII, антигеном ФVIII (ФVIII:Ag), антигеном фактора Віллебранда (vWF:Ag). Результати. До введення препарату ФVIII тести, які обумовлюють коагуляційний гемостаз є достовірно подовженими порівняно із здоровими особами. У ТВ до введення препарату показники ТЕГ, які залежать від рівня прокоагулянтів є порушеними у бік гіпокоагуляції. Через 30 хв після введення АЧТЧ, І АЧТЧ, активність ФVIII та ФVIII:Ag, R, ТМА, α-Angel, СІ, SP нормалізуються. Висновки. ТЕГ є надійним методом контролю профілактичного лікування та ТВ у хворих на тяжку форму гемофілії А. Аналізу підлягають показники, значення яких залежить від рівня прокоагулянтів: час реакції R, час досягнення максимальної амплітуди ТМА, кут  нахилу до дотичної ТЕГ α-Angel, загальний коагуляційний  потенціал СI, час від початку тесту до утворення перших ниток фібрину SP. Показники ТЕГ, які характеризують силу, якість, гемостатичні можливості, лізис згустку та залежать від вмісту фібриногену і тромбоцитів, не відрізняються від відповідних показників здорових осіб та є неінформативними для контролю замісної трансфузійної терапії та ТВ у хворих на гемофілію. У хворих на гемофілію моніторинг профілактичного лікування та появи інгібіторів до ФVIII може здійснюватись на основі ТВ за допомогою ТЕГ у комплексі із іншими тестами дослідження гемостазу: АЧТЧ, І АЧТЧ, активність ФVIII та ФVIII:Ag.
КЛІНІЧНІ І МОРФОЛОГІЧНІ ПАРАЛЕЛІ ЗМІН СТІНКИ ВАРИКОЗНО РОЗШИРЕНИХ ВЕН У ЖІНОК РЕПРОДУКТИВНОГО ПЕРІОДУ
Authors: Криса Б. В.
Published: June 2019

Мета роботи. Клінічна оцінка мікроструктурних змін венозної стінки при варикозному розширенні вен у жінок репродуктивного періоду.

Матеріали і методи. Дослідження проведено у 2015–2018 роках на базі кафедри хірургії № 1 Івано-Франківського національного медичного університету. Залучено 43 жінки віком від 18 до 39 років. В час операції брали фрагменти підшкірної вени і фіксували у 10% розчині нейтрального формаліну. Після зневоднення вени заливали парафіном. Готували зрізи товщиною 5-7 мкм і фарбували гематоксилін-еозином та пікрофуксином за Ван Гізоном. Вивчали зрізи стінки на світловому мікроскопі «CARL ZEISS Axiostar-plus».

Результати та їх обговорення. Візуально видалені вени нерівномірно розширені, у зонах варикозних вузлів витончені. При мікроскопічному дослідженні у початкових стадіях варикозної хвороби (клас С1-С2 за СЕАР) виявляються гіпертрофія м’язової оболонки, запальні інфільтрати, частково заміщені сполучною тканиною. При декомпенсації венозного відтоку (клас С3 за СЕАР) набряк і гіпертрофія стінки змінюються атрофією міозитів, збільшенням кількості сполучної тканини, гіалінозом артеріол мікроциркуляторного русла стінки вени, розростанням грубоволокнистої сполучної тканини, яка заміщає гладком’язові волокна.

Висновки. При прогресуванні варикозного розширення у стінці вени розвиваються дегенеративно-деструктивні зміни у вигляді гіалінозу і заміщення гладком’язових волокон сполучною тканиною. Клінічне прогресування венозної недостатності відповідає варикозній трансформації стінки вени і корелює із прогресуванням деструктивних патогістологічних змін вени, що свідчить про її незворотні морфологічні зміни.

Ключові слова. Варикозна хвороба, морфологічні зміни вени.
ЕФЕКТИВНІСТЬ МЕЛЬДОНІЮ ДИГІДРАТУ В КОМПЛЕКСНОМУ ЛІКУВАННІ ХВОРИХ НА АРТЕРІАЛЬНУ ГІПЕРТЕНЗІЮ З ХРОНІЧНИМ ПІЄЛОНЕФРИТОМ
Authors: Лучко О. Р.
Published: June 2019

Резюме. Метою було дослідити ефективність мельдонію дигідрату у лікуванні хворих на артеріальну гіпертензію (АГ) з хронічним пієлонефритом (ХПН).
Gago, G. (Realizador). (2017). Matria [Filme]. Espanha: Sombriza Films, Ringo Media.
Authors: Cerqueira Carla
Published: June 2019

A curta-metragem Matria [2017], uma produção de Sombriza Films (Galiza) e Ringo Media (Catalunha), da autoria do jovem realizador galego Álvaro Gago [Vigo, 1986] e com o apoio de AGADIC – Agência Galega de Indústrias Culturais, relata um dia na vida de Ramona [Francisca Iglesias Bouzón], uma mulher de cerca de 50 anos, operária de uma fábrica de conservas na zona costeira da Galiza...
FOAM GYPSUM PRODUCTS BASED ON LOCAL BINDERS
Authors: Bagdasarov A. S. , Nesterenko A. I. , Pupkova A. Yu.
Published: June 2019

Objectives. The problems of production of porous gypsum products on a local gypsum binder in the Karachay-Cherkess Republic are considered. Method. The study is based on the method of "dry" mineralization of foams, developed at the Moscow State University of Civil Engineering. As the source materials used plaster binder brand G-6 Ust-Dzhegutinsky plaster plant. An alkyl dimethylamine oxide (amine oxide) foaming agent was chosen as a foaming agent (PO). The choice of software is made taking into account its compatibility with the gypsum binder. At the same time, software of various classes was studied. Studies were performed to obtain foamed gypsum with an average density of 900 kg / m3. Result. A technology for the production of foam gypsum is proposed, based on the technology for the production of foam concrete by the method of “dry” mineralization of foams. The choice of foaming agent was made by comparative evaluation of the studied parameters of foaming agents of various classes. A technique has been developed for designing foamed gypsum formulations to produce products of a given average density. The technique includes the determination of the flow rate of HS, water flow and foaming agent, the determination of the B / T ratio. It was proposed to design the GHG compositions based on a given design average material density (), which in this case is equal to the consumption of dihydrate gypsum (CaSO42H2O). In the proposed method of obtaining foam – gypsum masses, the distinctive feature is the use of the technological properties of dense foams with low multiplicity. The boundary conditions for obtaining wall foam-gypsum products from a local gypsum binder that meet the requirements of GOST have been determined. Conclusion. Using modern research methods, it has been established that foam-hypo products from Ust-Dzhegutinsky gypsum of grade G-6 meet the requirements of standards for building heat-insulating and construction-heatinsulating products with a density of 400-1000 kg / m 3.
TO THE QUESTION OF THE PROBABILITY OF THE ATTACKMENT OF DAMAGE AS A RESULT OF ATTACK ON THE INFORMATION RESOURCE OF INFORMATION AND TECHNICAL SYSTEMS OF INTERNAL AFFAIRS TYPE "REFUSAL IN SERVICE"
Authors: Alekhin I. V. , Bokova O. I. , Korobkin D. I. , Rogozin E. A.
Published: June 2019

Objectives In order to improve the security of departmental information technology systems and the rationality of the financial costs of hardware solutions in such systems, it is advisable to develop a simulation model of the information technology system of an internal affairs authority (ITS ATS) connected to the Internet to determine the likelihood of damage occurring denial of service attacks. Lead and clarify for the ITS ATS a classification of modern-time complex ITS, which will allow identifying possible threats to the ITS information resource ATS based on open federal and departmental regulatory documents in connection with Internet connection. Further development of the ATS ITS model was done in the Anylogic simulation environment, which makes it possible to simulate a denial of service attack on a departmental resource and investigate the likelihood of damage occurring. The expressions from the apparatus of queuing systems are given, which allow modeling the attack and calculating the probability of damage occurrence, which is advisable to use when designing such systems in ATS. Method. Analytical and mathematical modeling using the apparatus of queuing systems. Result. A simulation model of ITS ATS is proposed, which allows to determine the probability of a destructive impact on the departmental resources of such systems. Conclusion. The direction of this study is relevant and requires further development in order to develop a methodology for assessingthe occurrence of damage in ITS ATS.
Developing an instrument to evaluate the influential factors of the success of local curriculum
Authors: Andrian Dedek
Published: June 2019

The purpose of this study is to create an instrument to evaluate the factors that influence the success of the local curriculum in senior high school. The instrument developed is essential to find out what factors influence the success of the local curriculum. This research is a research and development which consists of three stages: (1) initial investigation, (2) design and validation stages, (3) trials, evaluations, and revisions. The results of small scale trials were analyzed using EFA (Exploratory Factor Analysis), obtaining one invalid item from 32 items. The results of a wide-scale test analyzed using CFA (Confirmatory Factor Analysis) obtained all indicators have loading factors 0.3 and reliability constructs 0.7. The results of the analysis show that the developed instrument fits the data obtained in the field. From the constructs of the instrument development, it is indicated that there are nine influential factors, consisting of regional government support, local community support, local industry support, academic community support, student interest, student motivation, practical tools, practical materials, and funds to buy lab material. The instrument developed has been used properly to obtain information about the factors that influence the success of the local curriculum.
Blended Learning Mobility Approach and English Language Learning
Authors: Ghareb Mazen Ismaeel , Mohammed Saman Ali
Published: June 2019

Although the benefits of blended learning have been well documented in educational research, relatively few studies have examined blended mobilities in education in Kurdistan region government and in Iraq. This study discusses a blended mobility approach for a teacher training program designed for in-service English language teachers (ELT) and investigates its effectiveness by comparing the latest participation of the University of Human Development for computer science and proposing the same program for training English for lecturers and students. The research involved proposes new mobility program for teaching and learning English language and using their language skills in an ongoing business project using several software for communication and management of their projects. Results will show the framework for new blended learning and blended mobilities of many different English language teaching (ELT) aspects.
Factors in Randomized Controlled Trials Reported to Impact the Implementation of Patient-Reported Outcome Measures Into Routine Care: Protocol for a Systematic Review
Authors: Roberts Natasha Anne , Alexander Kimberly , Wyld David , Janda Monika
Published: June 2019

Background

Patient-reported outcome measures (PROMs) are tools that enable patients to directly report their own assessments of well-being, or symptoms, in a structured and consistent way. Despite the usefulness of PROMs in optimizing health outcomes, their use in clinical practice is not routine. PROMs are complex to integrate into the clinical setting, with many elements potentially impacting on the success of implementation. For this reason, a protocol has been developed to guide a systematic review to collate information on implementation as presented in the randomized controlled trials (RCTs) to date.

Objective

The primary objective of this systematic review is to identify and synthesize factors available from RCT data about the fidelity of PROM interventions in clinical practice. The secondary objective will be an assessment of how implementation factors impact fidelity outcomes.

Methods

Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting standards will be followed. MEDLINE, EMBASE, and the Cumulative Index to Nursing and Allied Health Literature via OvidSP will be accessed using a defined search strategy. Grey literature and ClinicalTrials.gov will be reviewed for unpublished studies. Data extraction will be done to identify fidelity and factors impacting implementation, summarized using a narrative synthesis. An evidence-based implementation science framework will assist in identifying potential elements of importance and their effect on the process and outcomes of implementation. A meta-analysis to assess the impact of implementation factors will be attempted. A Cochrane risk of bias tool will be used.

Results

This protocol has received funding, and searches of databases will commence at the end of May 2019. It is planned that this systematic review will be finalized for publication in (December) 2019.

Conclusions

Applying an implementation science evidence-based framework to the published literature may identify factors present in the data that impact on the implementation of PROMs into routine clinical care. This systematic review aims to improve understanding of how these factors impact the fidelity of this intervention, so that PROMs can be more effectively used in the care of patients. This systematic review can also offer more detailed information about the process and outcomes of successful implementation of PROMs.

International Registered Report Identifier (IRRID)

PRR1-10.2196/14579
Specialized Smartphone Intervention Apps: Review of 2014 to 2018 NIH Funded Grants
Authors: Hansen William B , Scheier Lawrence M
Published: June 2019

Background

The widespread adoption of smartphones provides researchers with expanded opportunities for developing, testing and implementing interventions. National Institutes of Health (NIH) funds competitive, investigator-initiated grant applications. Funded grants represent the state of the science and therefore are expected to anticipate the progression of research in the near future.

Objective

The objective of this paper is to provide an analysis of the kinds of smartphone-based intervention apps funded in NIH research grants during the five-year period between 2014 and 2018.

Methods

We queried NIH Reporter to identify candidate funded grants that addressed mHealth and the use of smartphones. From 1524 potential grants, we identified 397 that met the requisites of including an intervention app. Each grant’s abstract was analyzed to understand the focus of intervention. The year of funding, type of activity (eg, R01, R34, and so on) and funding were noted.

Results

We identified 13 categories of strategies employed in funded smartphone intervention apps. Most grants included either one (35.0%) or two (39.0%) intervention approaches. These included artificial intelligence (57 apps), bionic adaptation (33 apps), cognitive and behavioral therapies (68 apps), contingency management (24 apps), education and information (85 apps), enhanced motivation (50 apps), facilitating, reminding and referring (60 apps), gaming and gamification (52 apps), mindfulness training (18 apps), monitoring and feedback (192 apps), norm setting (7 apps), skills training (85 apps) and social support and social networking (59 apps). The most frequently observed grant types included Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants (40.8%) and Research Project Grants (R01s) (26.2%). The number of grants funded increased through the five-year period from 60 in 2014 to 112 in 2018.

Conclusions

Smartphone intervention apps are increasingly competitive for NIH funding. They reflect a wide diversity of approaches that have significant potential for use in applied settings.
Toward an Integrative Framework of Dynamic Capabilities in Innovation-based Public Services: Empirical Analysis in Taiwan
Authors: Fu Kai-Jo , Chang Teng-Wen
Published: June 2019

With the growing significance of public services in developed countries, there is an increased interest in the role of service innovation in governments. While most studies provide empirical analysis on how innovation serves as a promising means of improving public services, little attention has been paid to recognizing which assets and dynamic capabilities are at the heart of service innovation and how successful examples can be identified or classified. The view on this subject remains fragmented, reflecting the need to explore how institutional incentives affect public service innovation. Therefore, the focus of this study is to theorize the concept of service innovation in the public sector to achieve a consensus regarding what types of competitive strategy are the main components of innovation-based public services and to what extent their emergence can be set in motion by institutional design or policy interventions. Based on applications of the public service innovation awards launched by the central government in Taiwan, this paper illustrates the trajectory of innovation through the different approaches of public management. The methods of data collection and analyses of the award-winning agencies are outlined, followed by cluster analysis. The results of the analyses and findings are discussed, and finally, implications for theory and practice are provided.
La imitación como contraargumento en peritajes de atribución de autoría: estudio de un caso
Authors: Queralt Sheila , Giménez García Roser
Published: June 2019

Este artículo tiene como objetivo probar el supuesto de que el estilo de un autor en textos escritos no solo es único, sino también irrepetible. El marco teórico apoya este supuesto e indica que se requeriría un gran dominio lingüístico y la capacidad de sostener un alto grado de atención consciente, los cuales son muy difíciles de alcanzar. El estudio se basa en el material de un caso real de chantaje a un funcionario público, en el que participó una de las autoras, así como un corpus de textos producidos con el fin de imitar el estilo del funcionario. Se empleó una combinación de análisis cualitativo para la identificación de estructuras marcadas y prominentes con un análisis cuantitativo de estadística descriptiva. Se observó que los imitadores únicamente reproducen los rasgos más visibles y no son capaces de identificar e incorporar todos los atributos de la escritura del autor original en sus textos. Además, en el caso de detectar una marca particular, no la reproducen con la misma frecuencia. Los resultados permiten refutar la hipótesis sobre la posibilidad de la imitación del estilo de un autor de forma suficientemente meticulosa y consistente para evitar ser detectado por un lingüista forense.
El debate sobre la Guardia Nacional
Authors: Cárdenas Gracia Jaime
Published: June 2019

El trabajo expone las razones que impulsan al gobierno y a otros actores a aprobar la Guardia Nacional para México. Se describe y cuestiona la reforma constitucional. Se proporcionan argumentos para sostener que la seguridad en un Estado Constitucional de Derecho corresponde a la autoridad civil y no a las fuerzas armadas. En las conclusiones argumentamos sobre los riesgos que entraña la Guardia Nacional.
 
Materia legislativa relativa al derecho a la interpretación y a la traducción en los procesos penales para las personas sordas
Authors: Ibáñez Castaño Ángela
Published: June 2019

A lo largo de la historia, las personas sordas se han encontrado con barreras comunicativas e informativas a la hora de acceder a todos los servicios públicos, incluida la Administración de Justicia. Al no haber uniformidad en la aplicación de mecanismos de protección de los derechos de las personas sospechosas o acusadas surgió la necesidad de armonizar las leyes en la Unión Europea por lo que se aprueba la Directiva Europea 2010/64/UE relativa al derecho a la interpretación y a la traducción para los sospechosos, imputados o acusados que no conocen el idioma del proceso penal. En España, por medio de la transposición de la misma al ordenamiento jurídico español se aprueba la Ley Orgánica 5/2015, en la cual, se modifica la Ley de Enjuiciamiento Criminal y la Ley Orgánica del Poder Judicial.
La personalidad jurídica y los derechos humanos
Authors: Suárez López Beatriz Eugenia
Published: June 2019

El presente artículo complementa el estudio realizado sobre el alcance que se ha otorgado al derecho al reconocimiento de la personalidad jurídica por parte de la Corte Interamericana de Derechos Humanos. De tal modo, se aborda un desarrollo jurisprudencial del mencionado derecho al interior de las decisiones del tribunal internacional, con el fin de fijar el contenido de su protección y las obligaciones de los Estados en torno suyo. Para ello, se emplea como método de recolección de la jurisprudencia denominado método censitario adaptado y se exponen los resultados adicionales al tema conexo de las “desapariciones forzadas”, para finalizar con las conclusiones.