bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis and Evaluation of Non-Pharmaceutical Interventions on Prevention and Control of COVID-19: A Case Study of Wuhan City
Authors: Cao Wen , Dai Haoran , Zhu Jingwen , Tian Yuzhen , Peng Feilin
Published: July 2021

As the threat of COVID-19 increases, many countries have carried out various non-pharmaceutical interventions. Although many studies have evaluated the impact of these interventions, there is a lack of mapping between model parameters and actual geographic areas. In this study, a non-pharmaceutical intervention model of COVID-19 based on a discrete grid is proposed from the perspective of geography. This model can provide more direct and effective information for the formulation of prevention and control policies. First, a multi-level grid was introduced to divide the geographical space, and the properties of the grid boundary were used to describe the quarantine status and intensity in these different spaces; this was also combined with the model of hospital isolation and self-protection. Then, a process for the spatiotemporal evolution of the early COVID-19 spread is proposed that integrated the characteristics of residents’ daily activities. Finally, the effect of the interventions was quantitatively analyzed by the dynamic transmission model of COVID-19. The results showed that quarantining is the most effective intervention, especially for infectious diseases with a high infectivity. The introduction of a quarantine could effectively reduce the number of infected humans, advance the peak of the maximum infected number of people, and shorten the duration of the pandemic. However, quarantines only function properly when employed at sufficient intensity; hospital isolation and self-protection measures can effectively slow the spread of COVID-19, thus providing more time for the relevant departments to prepare, but an outbreak will occur again when the hospital reaches full capacity. Moreover, medical resources should be concentrated in places where there is the most urgent need under a strict quarantine measure.
Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases
Authors: Gubert Fernanda , da Silva Jaqueline Soares , Vasques Juliana F. , de Jesus Gonçalves Renata Guedes , Martins Robertta Silva , de Sá Mauro Paes Leme , Mendez-Otero Rosalia , Zapata-Sudo Gisele
Published: July 2021

Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of normal function, something which may end up causing progressive and irreversible dysfunction. Many factors lead to cardiac fibrosis and failure, and an effective therapy is lacking to reverse or attenuate this condition. Different approaches have been shown to be promising in surpassing the poor survival of transplanted cells in cardiac tissue to provide cardioprotection and prevent cardiac remodeling. This review includes the description of pre-clinical and clinical investigation of the therapeutic potential of MSCs in improving ventricular dysfunction consequent to diverse cardiac diseases.
Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants
Authors: Alghuthaymi Mousa A. , Ahmad Aftab , Khan Zulqurnain , Khan Sultan Habibullah , Ahmed Farah K. , Faiz Sajid , Nepovimova Eugenie , Kuča Kamil , Abd-Elsalam Kamel A.
Published: July 2021

Rapid developments in the field of plant genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems necessitate more detailed consideration of the delivery of the CRISPR system into plants. Successful and safe editing of plant genomes is partly based on efficient delivery of the CRISPR system. Along with the use of plasmids and viral vectors as cargo material for genome editing, non-viral vectors have also been considered for delivery purposes. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, and protein- and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have a decreased immune response, an advantage over viral vectors, and offer additional flexibility in their design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. This review is dedicated to describing the delivery methods of CRISPR system into plants with emphasis on the use of non-viral vectors.
Pharmacological Treatment for Social Cognition: Current Evidence
Authors: Riccardi Cecilia , Montemagni Cristiana , Del Favero Elisa , Bellino Silvio , Brasso Claudio , Rocca Paola
Published: July 2021

Cognitive impairment is currently considered a core feature of schizophrenia (SZ) and is gaining attention as a fundamental therapeutic target. Standard treatment for SZ involves the use of antipsychotics that are successfully used to control positive symptoms and disorganized behaviour. However, it is still unclear whether they are effective on social cognition (SC) impairment. Furthermore, different medications are currently being studied to improve SC in patients with SZ. A literature search on this topic was conducted using the PubMed database. All kinds of publications (i.e., reviews, original contributions and case reports) written in English and published in the last 15 years were included. The aim of our literature review is to draw a picture of the current state of the pharmacological treatment of SC impairment in SZ.
Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice
Authors: Carry Eileen , Kshatriya Dushyant , Silva Joshua , Davies Daryl L. , Yuan Bo , Wu Qingli , Patel Harna , Park Elizabeth R. , Gilleran John , Hao Lihong , Roberge Jacques , Bello Nicholas T. , Simon James E.
Published: July 2021

Dihydromyricetin is a natural bioactive flavonoid with unique GABAA receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical utility, the promise of this mechanism for the treatment of alcohol use disorder warrants further investigation into its specificity and druggable potential. These experiments investigated the bioavailability of dihydromyricetin in the brain and serum associated with acute anti-intoxicating effects in C57BL/6J mice. Dihydromyricetin (50 mg/kg IP) administered 0 or 15-min prior to ethanol (PO 5 g/kg) significantly reduced ethanol-induced loss of righting reflex. Total serum exposures (AUC0→24) of dihydromyricetin (PO 50 mg/kg) via oral (PO) administration were determined to be 2.5 µM × h (male) and 0.7 µM × h (female), while intraperitoneal (IP) administration led to 23.8-fold and 7.2- increases in AUC0→24 in male and female mice, respectively. Electrophysiology studies in α5β3γ2 GABAA receptors expressed in Xenopus oocytes suggest dihydromyricetin (10 µM) potentiates GABAergic activity (+43.2%), and the metabolite 4-O-methyl-dihydromyricetin (10 µM) negatively modulates GABAergic activity (−12.6%). Our results indicate that administration route and sex significantly impact DHM bioavailability in mice, which is limited by poor absorption and rapid clearance. This correlates with the observed short duration of DHM’s anti-intoxicating properties and highlights the need for further investigation into mechanism of DHM’s potential anti-intoxicating properties.
Additive Manufacturing of Gold Nanostructures Using Nonlinear Photoreduction under Controlled Ionic Diffusion
Authors: Di Cianni Wera , de la Mata María , Delgado Francisco J. , Desiderio Giovanni , Molina Sergio I. , de León Alberto S. , Giocondo Michele
Published: July 2021

Multiphoton photoreduction of photosensitive metallic precursors via direct laser writing (DLW) is a promising technique for the synthesis of metallic structures onto solid substrates at the sub-micron scale. DLW triggered by a two photon absorption process is done using a femtosecond NIR laser (λ = 780 nm), tetrachloroauric acid (HAuCl4) as a gold precursor, and isinglass as a natural hydrogel matrix. The presence of a polymeric, transparent matrix avoids unwanted diffusive processes acting as a network for the metallic nanoparticles. After the writing process, a bath in deionized water removes the gold precursor ions and eliminates the polymer matrix. Different aspects underlying the growth of the gold nanostructures (AuNSs) are here investigated to achieve full control on the size and density of the AuNSs. Writing parameters (laser power, exposure time, and scanning speed) are optimized to control the patterns and the AuNSs size. The influence of a second bath containing Au3+ to further control the size and density of the AuNSs is also investigated, observing that these AuNSs are composed of individual gold nanoparticles (AuNPs) that grow individually. A fine-tuning of these parameters leads to an important improvement of the created structures’ quality, with a fine control on size and density of AuNSs.
Global Transcriptional Analyses of the Wnt-Induced Development of Neural Stem Cells from Human Pluripotent Stem Cells
Authors: Liu Bing-Chun , Liu Fang-Yuan , Gao Xin-Yue , Chen Yang-Lin , Meng Qiao-Qiao , Song Yong-Li , Li Xi-He , Bao Si-Qin
Published: July 2021

The differentiation of human pluripotent stem cells (hPSCs) to neural stem cells (NSCs) is the key initial event in neurogenesis and is thought to be dependent on the family of Wnt growth factors, their receptors and signaling proteins. The delineation of the transcriptional pathways that mediate Wnt-induced hPSCs to NSCs differentiation is vital for understanding the global genomic mechanisms of the development of NSCs and, potentially, the creation of new protocols in regenerative medicine. To understand the genomic mechanism of Wnt signaling during NSCs development, we treated hPSCs with Wnt activator (CHIR-99021) and leukemia inhibitory factor (LIF) in a chemically defined medium (N2B27) to induce NSCs, referred to as CLNSCs. The CLNSCs were subcultured for more than 40 passages in vitro; were positive for AP staining; expressed neural progenitor markers such as NESTIN, PAX6, SOX2, and SOX1; and were able to differentiate into three neural lineage cells: neurons, astrocytes, and oligodendrocytes in vitro. Our transcriptome analyses revealed that the Wnt and Hedgehog signaling pathways regulate hPSCs cell fate decisions for neural lineages and maintain the self-renewal of CLNSCs. One interesting network could be the deregulation of the Wnt/β-catenin signaling pathway in CLNSCs via the downregulation of c-MYC, which may promote exit from pluripotency and neural differentiation. The Wnt-induced spinal markers HOXA1-4, HOXA7, HOXB1-4, and HOXC4 were increased, however, the brain markers FOXG1 and OTX2, were absent in the CLNSCs, indicating that CLNSCs have partial spinal cord properties. Finally, a CLNSC simple culture condition, when applied to hPSCs, supports the generation of NSCs, and provides a new and efficient cell model with which to untangle the mechanisms during neurogenesis.
Special Issue on Molecular and Translational Research on Colorectal Cancer 2.0
Authors: Passardi Alessandro , Scarpi Emanuela , Ulivi Paola
Published: July 2021

The present editorial aims to summarise the six scientific papers that have contributed to this Special Issue, focusing on different aspects of molecular and translational research on colorectal cancer. We believe that the present Special Issue might contribute to the expansion of the current knowledge concerning potential molecular predictive and/or prognostic biomarkers in CRC, as well as new targets for anticancer treatment. This may help in identifying new strategies to improve diagnostic and therapeutic approaches.
Arene-Osmium(II) Complexes in Homogeneous Catalysis
Authors: Crochet Pascale , Cadierno Victorio
Published: July 2021

Although the application of arene-osmium(II) complexes in homogeneous catalysis has been much less studied than that of their ruthenium analogues, different works have shown that, in some instances, a comparable or even superior effectiveness can be achieved with this particular class of compounds. This review article focuses on the catalytic applications of arene-osmium(II) complexes. Among others, transfer hydrogenation, hydrogenation, oxidation, and nitrile hydration reactions, as well as different C-C bond forming processes, are comprehensively discussed.
Drosophila suzukii Susceptibility to the Oral Administration of Bacillus thuringiensis, Xenorhabdus nematophila and Its Secondary Metabolites
Authors: Mastore Maristella , Caramella Sara , Quadroni Silvia , Brivio Maurizio Francesco
Published: July 2021

Drosophila suzukii, Spotted Wing Drosophila (SWD), is a serious economic issue for thin-skinned fruit farmers. The invasion of this dipteran is mainly counteracted by chemical control methods; however, it would be desirable to replace them with biological control. All assays were performed with Bacillus thuringiensis (Bt), Xenorhabdus nematophila (Xn), and Xn secretions, administered orally in single or combination, then larval lethality was assessed at different times. Gut damage caused by Bt and the influence on Xn into the hemocoelic cavity was also evaluated. In addition, the hemolymph cell population was analyzed after treatments. The data obtained show that the combined use of Bt plus Xn secretions on larvae, compared to single administration of bacteria, significantly improved the efficacy and reduced the time of treatments. The results confirm the destructive action of Bt on the gut of SWD larvae, and that Bt-induced alteration promotes the passage of Xn to the hemocoel cavity. Furthermore, hemocytes decrease after bioinsecticides treatments. Our study demonstrates that combining bioinsecticides can improve the efficacy of biocontrol and such combinations should be tested in greenhouse and in field in the near future.
Low and High Frequency Vibration Perception Thresholds Can Improve the Diagnosis of Diabetic Neuropathy
Authors: Drechsel Tina J. , Monteiro Renan L. , Zippenfennig Claudio , Ferreira Jane S. S. P. , Milani Thomas L. , Sacco Isabel C. N.
Published: July 2021

Recent studies demonstrate neuropathic changes with respect to vibration sensitivity for different measurement frequencies. This study investigates the relationship between vibration perception thresholds (VPTs) at low and high frequencies at two plantar locations and diabetic peripheral neuropathy (DPN) severity in diabetes mellitus (DM) subjects with DPN. We examine differences of VPTs between participants with DM, with DPN, as well as healthy controls. The influence of anthropometric, demographic parameters, and DM duration on VPTs is studied. Thirty-three healthy control group subjects (CG: 56.3 ± 9.9 years) and 33 with DM are studied. DM participants are subdivided into DM group (DM without DPN, n = 20, 53.3 ± 15.1 years), and DPN group (DM with DPN, n = 13, 61.0 ± 14.5 years). VPTs are measured at the first metatarsal head (MTH1) and heel (30 Hz, 200 Hz), using a customized vibration exciter. Spearman and Pearson correlations are used to identify relationships between VPTs and clinical parameters. ANOVAs are calculated to compare VPTs among groups. Significant correlations are observed between DPN severity (by fuzzy scores) and VPTs at both locations and frequencies (MTH1_30 Hz vs. fuzzy: r = 0.68, p = 0.011; Heel_30 Hz vs. fuzzy: r = 0.66, p = 0.014; MTH1_200 Hz vs. fuzzy: r = 0.73, p = 0.005; Heel_200 Hz vs. fuzzy: r = 0.60, p = 0.032). VPTs in CG and DM groups are significantly smaller than the DPN group, showing higher contrasts for the 30 Hz compared to the 200 Hz measurement. The correlations between fuzzy scores and VPTs confirm the relevance of using low and high frequencies to assess a comprehensive foot sensitivity status in people with DM.
The Spatial Selective Auditory Attention of Cochlear Implant Users in Different Conversational Sound Levels
Authors: Akbarzadeh Sara , Lee Sungmin , Tan Chin-Tuan
Published: July 2021

In multi-speaker environments, cochlear implant (CI) users may attend to a target sound source in a different manner from normal hearing (NH) individuals during a conversation. This study attempted to investigate the effect of conversational sound levels on the mechanisms adopted by CI and NH listeners in selective auditory attention and how it affects their daily conversation. Nine CI users (five bilateral, three unilateral, and one bimodal) and eight NH listeners participated in this study. The behavioral speech recognition scores were collected using a matrix sentences test, and neural tracking to speech envelope was recorded using electroencephalography (EEG). Speech stimuli were presented at three different levels (75, 65, and 55 dB SPL) in the presence of two maskers from three spatially separated speakers. Different combinations of assisted/impaired hearing modes were evaluated for CI users, and the outcomes were analyzed in three categories: electric hearing only, acoustic hearing only, and electric + acoustic hearing. Our results showed that increasing the conversational sound level degraded the selective auditory attention in electrical hearing. On the other hand, increasing the sound level improved the selective auditory attention for the acoustic hearing group. In the NH listeners, however, increasing the sound level did not cause a significant change in the auditory attention. Our result implies that the effect of the sound level on selective auditory attention varies depending on the hearing modes, and the loudness control is necessary for the ease of attending to the conversation by CI users.
Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion
Authors: Marcinkowska Adrianna , Cisiecki Slawomir , Rozalski Marcin
Published: July 2021

Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on both local and systemic factors, which can be divided into vascular, platelet, and hypercoagulable factors. The vascular factors include dyslipidaemia, high blood pressure, and diabetes mellitus. Regarding the platelet factors, platelet function, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) play key roles in the diagnosis of retinal vein occlusion and should be monitored. Nevertheless, the role of a hypercoagulable state in retinal vein occlusion remains unclear and requires further studies. Therefore, the following article will present the risk factors of RVO associated with coagulation disorders, as well as the acquired and genetic risk factors of thrombophilia. According to Virchow’s triad, all factors mentioned above lead to thrombus formation, which causes pathophysiological changes inside venous vessels in the fundus of the eye, which in turn results in the vessel occlusion. Therefore, a diagnosis of retinal vein occlusion should be based on both eye examination and general examination, including laboratory tests.
Clinical and Radiological Results of Hemiarthroplasty and Total Shoulder Arthroplasty for Primary Avascular Necrosis of the Humeral Head in Patients Less Than 60 Years Old
Authors: Hervé Anthony , Chelli Mickael , Boileau Pascal , Walch Gilles , Favard Luc , Levigne Christophe , Sirveaux François , Clavert Philippe , Bonnevialle Nicolas , Collin Philippe
Published: July 2021

Background: Total shoulder arthroplasty (TSA) and hemiarthroplasty (HA) have shown good clinical outcomes in primary avascular necrosis of the humeral head (PANHH) both in short and long terms. The purpose of this study was to assess the complications, the clinical and radiological outcomes of shoulder arthroplasty in young patients with PANHH. Methods: One hundred and twenty-seven patients aged under 60 years old and suffering from PANHH were operated with arthroplasty. Patients were assessed clinically and radiographically before surgery with a minimum of 2 years of follow up (FU). Results: HA was performed on 108 patients (85%). Two patients were revised for painful glenoid wear after 2 and 4 years. TSA was performed on 19 patients (15%). Five TSA had to be revised for glenoid loosening (n = 4) or instability (n = 1). Revision rate was 26% with TSA and 2% with HA. There were no significant differences between HA and TSA in terms of clinical outcomes. Conclusions: With a mean FU of 8 years, HA and TSA improved clinical outcomes of patients with PANHH. HA revisions for painful glenoid wear were rare (2%). The revision rate was excessively high with TSA (26%).
Influence of End Mill Manufacturing on Cutting Edge Quality and Wear Behavior
Authors: Denkena Berend , Krödel-Worbes Alexander , Beblein Sascha , Hein Markus
Published: July 2021

One of the decisive factors for the performance of milling tools is the quality of the cutting edge. The latter results from the process control of the individual steps along the tool manufacturing process chain, which generally includes the sintering or pressing of the blanks, grinding, cutting edge preparation, and coating of the tools. However, the targeted and application-specific design of the process steps in terms of high economic efficiency is currently limited by a lack of knowledge regarding the influence of the corresponding process parameters on the resulting cutting edge quality. In addition, there is a lack of suitable parameters that adequately represent the characteristics of the cutting edge microtopography. This publication therefore investigates the influence of manufacturing processes on cutting edge quality and wear behavior of end mills. On this basis, different characterization parameters for the cutting edge quality are derived and evaluated with regard to their ability to predict the wear behavior.
Sea Lice Are Sensitive to Low Frequency Sounds
Authors: Solé Marta , Lenoir Marc , Fortuño José-Manuel , De Vreese Steffen , van der Schaar Mike , André Michel
Published: July 2021

The salmon louse Lepeophtheirus salmonis is a major disease problem in salmonids farming and there are indications that it also plays a role in the decline of wild salmon stocks. This study shows the first ultrastructural images of pathological changes in the sensory setae of the first antenna and in inner tissues in different stages of L. salmonis development after sound exposure in laboratory and sea conditions. Given the current ineffectiveness of traditional methods to eradicate this plague, and the strong impact on the environment these treatments often provoke, the described response to sounds and the associated injuries in the lice sensory organs could represent an interesting basis for developing a bioacoustics method to prevent lice infection and to treat affected salmons.
A Fungal Defensin Targets the SARS−CoV−2 Spike Receptor−Binding Domain
Authors: Gao Bin , Zhu Shunyi
Published: July 2021

Coronavirus Disease 2019 (COVID−19) elicited by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS−CoV−2) is calling for novel targeted drugs. Since the viral entry into host cells depends on specific interactions between the receptor−binding domain (RBD) of the viral Spike protein and the membrane−bound monocarboxypeptidase angiotensin converting enzyme 2 (ACE2), the development of high affinity RBD binders to compete with human ACE2 represents a promising strategy for the design of therapeutics to prevent viral entry. Here, we report the discovery of such a binder and its improvement via a combination of computational and experimental approaches. The binder micasin, a known fungal defensin from the dermatophytic fungus Microsporum canis with antibacterial activity, can dock to the crevice formed by the receptor−binding motif (RBM) of RBD via an extensive shape complementarity interface (855.9 Å2 in area) with numerous hydrophobic and hydrogen−bonding interactions. Using microscale thermophoresis (MST) technique, we confirmed that micasin and its C−terminal γ−core derivative with multiple predicted interacting residues exhibited a low micromolar affinity to RBD. Expanding the interface area of micasin through a single point mutation to 970.5 Å2 accompanying an enhanced hydrogen bond network significantly improved its binding affinity by six−fold. Our work highlights the naturally occurring fungal defensins as an emerging resource that may be suitable for the development into antiviral agents for COVID−19.
Response of Fungal Diversity, Community Composition, and Functions to Nutrients Management in Red Soil
Authors: Muneer Muhammad Atif , Huang Xiaoman , Hou Wei , Zhang Yadong , Cai Yuanyang , Munir Muhammad Zeeshan , Wu Liangquan , Zheng Chaoyuan
Published: July 2021

Soil fungi play a critical role in plant performance and soil nutrient cycling. However, the understanding of soil fungal community composition and functions in response to different nutrients management practices in red soils remains largely unknown. Here, we investigated the responses of soil fungal communities and functions under conventional farmer fertilization practice (FFP) and different nutrient management practices, i.e., optimization of NPK fertilizer (O) with soil conditioner (O + C), with lime and mushroom residue (O + L + M), and with lime and magnesium fertilizer (O + L + Mg). Illumina high-throughput sequencing was used for fungal identification, while the functional groups were inferred with FUNGuild. Nutrient management practices significantly raised the soil pH to 4.79–5.31 compared with FFP (3.69), and soil pH had the most significant effect (0.989 ***) on fungal communities. Predominant phyla, including Ascomycota, Basidiomycota, and Mortierellomycota were identified in all treatments and accounted for 94% of all fungal communities. The alpha diversity indices significantly increased under nutrients management practices compared with FFP. Co-occurrence network analysis revealed the keystone fungal species in the red soil, i.e., Ascomycota (54.04%), Basidiomycota (7.58%), Rozellomycota (4.55%), and Chytridiomycota (4.04%). FUNGuild showed that the relative abundance of arbuscular mycorrhizal fungi and ectomycorrhizal fungi was higher, while pathogenic fungi were lower under nutrient management practices compared with FFP. Our findings have important implications for the understanding of improvement of acidic soils that could significantly improve the soil fungal diversity and functioning in acidic soils.
Equity Premium with Habits, Wealth Inequality and Background Risk
Authors: Giannikos Christos I. , Koimisis Georgios
Published: July 2021

In an exchange economy with endowment inequality, we investigate how preferences with external habits affect the equity risk premium. We show that the dynamics of external additive habits with wealth inequality are complex when a background risk is present. It is ambiguous whether wealth inequality will increase or decrease the equity premium even when the income uncertainty is low. This result extends literature by suggesting that wealth inequality has a small role in explaining asset pricing puzzles.
Special Issue: Agents and Robots for Reliable Engineered Autonomy
Authors: Cardoso Rafael C. , Ferrando Angelo , Briola Daniela , Menghi Claudio , Ahlbrecht Tobias
Published: July 2021

The study of autonomous agents is a well-established area that has been researched for decades, both from a design and implementation viewpoint [...]
Perception of Thermal Comfort during Skin Cooling and Heating
Authors: Mekjavic Igor B. , Yogev Daniel , Ciuha Urša
Published: July 2021

Due to the static and dynamic activity of the skin temperature sensors, the cutaneous thermal afferent information is dependent on the rate and direction of the temperature change, which would suggest different perceptions of temperature and of thermal comfort during skin heating and cooling. This hypothesis was tested in the present study. Subjects (N = 12; 6 females and 6 males) donned a water-perfused suit (WPS) in which the temperature was varied in a saw-tooth manner in the range from 27 to 42 °C. The rate of change of temperature of the water perfusing the suit (TWPS) was 1.2 °C min−1 during both the heating and cooling phases. The trial was repeated thrice, with subjects reporting their perception of the temperature and thermal comfort at each 3 °C change in TWPS. In addition, subjects were instructed to report when they perceived TWPS uncomfortably cool and warm during cooling and heating, respectively. Subjects reproducibly identified the boundaries of their Thermal Comfort Zone (TCZ), defined as the lower (Tlow) and upper (Thigh) temperatures at which subjects reported slight thermal discomfort. During the heating phase, Tlow and Thigh were 30.0 ± 1.5 °C and 35.1 ± 2.9 °C, respectively. During the cooling phase, the boundary temperatures of Tlow and Thigh were 35.4 ± 1.9 °C and 38.7 ± 2.3 °C, respectively. The direction of the change in the cutaneous temperature stimulus affects the boundaries of the TCZ, such that they are higher during cooling and lower during heating. These findings are explained on the basis of the neurophysiology of thermal perception. From an applied perspective, the most important observation of the present study was the strong correlation between the perception of thermal comfort and the behavioral regulation of thermal comfort. Although it is not surprising that the action of regulating thermal comfort is aligned with its perception, this link has not been proven for humans in previous studies. The results therefore provide a sound basis to consider ratings of thermal comfort as reflecting behavioral actions to achieve the sensation of thermal neutrality.
Microstructure and Fatigue Behaviors of Dissimilar A6061/Galvannealed Steel Joints Fabricated by Friction Stir Spot Welding
Authors: Kumamoto Koki , Kosaka Tsuyoshi , Kobayashi Tatsuya , Shohji Ikuo , Kamakoshi Yuichiro
Published: July 2021

The microstructures, tensile shear properties, and tensile shear fatigue properties of dissimilar A6061/Galvannealed steel joints fabricated by friction stir spot welding (FSSW) were investigated. Fe4Al13 phases form as the intermetallic compound (IMC) layer at the joint interface between the A6061 matrix and the galvannealed layer consisting of FeZn7, Fe, and Zn. At the edge of the joint, the stirred layer in which the A6061 matrix and the galvannealed layer are stirred also forms. Moreover, the solidified part of the residual melt discharged from the joint area forms at the outer peripheries of the joint. In this study, FSSW was conducted for two total welding durations: 9 and 10 s. Although the thickness of the remaining A6061 sheet in the welded area decreased with an increase in the welding time, the effects of the total welding time on tensile shear and tensile shear fatigue properties were negligible. A fatigue fracture occurred in the A6061 matrix and at the joint interface at the high cycle fatigue region and the low cycle fatigue region, respectively. In the case of the interfacial fracture, the crack was generated in the solidified part of the residual melt or at the interface between the solidified part and the stirred layer.
Influence of the Undercut Anchor Head Angle on the Propagation of the Failure Zone of the Rock Medium—Part II
Authors: Jonak Józef , Karpiński Robert , Wójcik Andrzej
Published: July 2021

Problems concerning the influence of the geometric parameters of an undercutting anchor on the range of the failure zone of rock medium during the pulling out of the anchor constitute one of the aspects that arouse the interest of authors due to attempts to use undercutting anchors in the process of rock lump separation. This method is considered an alternative to the existing methods of separation, especially in special cases of mining technologies. This article presents the results of numerical investigations into the effect of changes in the head geometry that occur as a result of wear on the conical part of the undercutting anchor and the extent of failure of the rock medium during its pulling out. This is an extension of considerations presented in previous work, where special attention was paid to the influence of potential errors in anchor installation, leading to changes in head geometry and, consequently, to changes in the extent of the failure zone of the rock medium. As a result, significant changes in the volume of the detached rock masses are observed. This study shows that the increasing surface friction of the stripping anchor head leads to a decrease in the angle of the undercutting head. As a result, the extent of the failure zone measured on the free rock surface increases, the value of the angle of the failure cone at the initial stage of the stripping decreases, and the deformation of rock in the plane perpendicular to the anchor axis increases.
Analysis of Parameters of a Rectified Tank on the Basis of In-Situ Tests
Authors: Gromysz Krzysztof
Published: July 2021

The vertical deflection of building structures is a common problem. However, the rectification of objects is rarely carried out due to the lack of information about the parameters of objects requiring rectification. The subject of the analysis are parameters of rectified water tank 950 m3 in volume, which were investigated due to the stiffness and number of supports built into the structure. During in-situ testing, the stiffnesses of supports were determined. The model of the rectified structure was then defined and it was shown that its parameters can be described by means of three matrices: stiffness, displacement forms of the elevated object and displacement forms of supports. Absolute values of elements of the stiffness matrix increased as the stiffness and number of supports increased. At the same time, values of elements of the matrix of displacement forms of the elevated object increased. The conducted energy analysis demonstrated that the amount of energy required for the vertical displacement of the structure decreased with an increasing stiffness and number of supports. This means that placing a greater number of supports under rectified structures and ensuring more rigid supports is beneficial to the rectification. Results of the conducted analyses were confirmed during in-situ tests.
CO2 Capture by Low-Cost Date Pits-Based Activated Carbon and Silica Gel
Authors: Danish Mohd , Parthasarthy Vijay , Al Mesfer Mohammed K.
Published: July 2021

The rising levels of CO2 in the atmosphere are causing escalating average global temperatures. The capture of CO2 by adsorption has been carried out using silica gel type III and prepared activated carbon. The date pits-based activated carbon was synthesized using a tubular furnace by physical activation. The temperature of the sample was increased at 10 °C/min and the biomass was carbonized under N2 flow maintained continuously for 2 h at 600 °C. The activation was performed with the CO2 flow maintained constantly for 2 h at 600 °C. The temperature, feed flow and adsorbate volume were the parameters considered for CO2 adsorption. The success of CO2 capture was analyzed by CO2 uptake, efficiency based on column capacity, utilization factors and the mass transfer zone. The massively steep profiles of the breakthrough response of the AC demonstrate the satisfactory exploitation of CO2 uptake under the conditions of the breakthrough. The SG contributed to a maximal CO2 uptake of 8.61 mg/g at 298 K and Co = 5% with F = 5 lpm. The enhanced CO2 uptake of 73.1 mg/g was achieved with a column efficiency of 0.94 for the activated carbon produced from date pits at 298 K. The AC demonstrated an improved performance with a decreased mass transfer zone of 1.20 cm with an enhanced utilization factor f = 0.97 at 298 K. This finding suggests that a date pits-based activated carbon is suitable for CO2 separation by adsorption from the feed mixture.
Bone Conduction Capacity of Highly Porous 3D-Printed Titanium Scaffolds Based on Different Pore Designs
Authors: Lim Ho-Kyung , Ryu Miyoung , Woo Su-Heon , Song In-Seok , Choi Young-Jun , Lee Ui-Lyong
Published: July 2021

In porous titanium scaffolds manufactured via 3D printing, the differences in bone formation according to pore design and implantation period were studied. Titanium scaffolds with three types of different pore structures (Octadense, Gyroid, and Dode) were fabricated via 3D printing using the selective laser melting method. Mechanical properties of scaffolds were investigated. Prepared specimens were inserted into both femurs of nine rabbits and their clinical characteristics were observed. Three animals were sacrificed at the 2nd, 4th, and 6th weeks, and the differences in bone formation were radiologically and histologically analyzed. The percentage of new bone and surface density in the pore structure were observed to be approximately 25% and 8 mm2/mm3, respectively. There was no difference in the amount of newly formed bone according to the pore design at 2, 4, and 6 weeks. In addition, no differences in the amount of newly formed bone were observed with increasing time within the same pore design for all three designs. During the 6-week observation period, the proportion of new bones in the 3D-printed titanium scaffold was approximately 25%. Differences in bone formation according to the pore design or implantation period were not observed.
The Force Cone Method Applied to Explain Hidden Whirls in Tribology
Authors: Mattheck Claus , Greiner Christian , Bethge Klaus , Tesari Iwiza , Weber Karlheinz
Published: July 2021

In tribologically loaded materials, folding instabilities and vortices lead to the formation of complex internal structures. This is true for geological as well as nanoscopic contacts. Classically, these structures have been described by Kelvin–Helmholtz instabilities or shear localization. We here introduce an alternative explanation based on an intuitive approach referred to as the force cone method. It is considered how whirls are situated near forces acting on a free surface of an elastic or elastoplastic solid. The force cone results are supplemented by finite element simulations. Depending on the direction of the acting force, one or two whirls are predicted by the simplified force cone method. In 3D, there is always a ring shaped whirl present. These modelling findings were tested in simple model experiments. The results qualitatively match the predictions and whirl formation was found. The force cone method and the experiments may seem trivial, but they are an ideal tool to intuitively understand the presence of whirls within a solid under a tribological load. The position of these whirls was found at the predicted places and the force cone method allows a direct approach to understand the complex processes in the otherwise buried interfaces of tribologically loaded materials.
Experimental Evaluation of Shrinkage, Creep and Prestress Losses in Lightweight Aggregate Concrete with Sintered Fly Ash
Authors: Szydłowski Rafał Stanisław , Łabuzek Barbara
Published: July 2021

The paper presents the experimental results of shrinkage, creep, and prestress loss in concrete with lightweight aggregate obtained by sintering of fly ash. Two concrete mixtures with different proportions of components were tested. Concrete with a density of 1810 and 1820 kg/m3, and a 28-day strength of 56.9 and 58.4 MPa was obtained. Shrinkage and creep were tested on 150 × 250 × 1000 mm3 beams. Creep was tested under prestressing load for 539 days and concrete shrinkage for 900 days. The measurement results were compared with the calculations carried out according to the Eurocode 2 as well as with the results of other research. A very low creep coefficient and lower shrinkage in relation to the calculation results and the results of other research were found. It was also revealed that there is a clear correlation between shrinkage and creep, and the amount of water in the concrete. The value of the creep coefficient during the load holding period was 0.610 and 0.537, which is 56.0 and 49.3% of the value determined from the standard. The prestressing losses in the analyzed period amounted to an average of 13.0%. Based on the obtained test results, it was found that the tested lightweight aggregate concrete is well suited for prestressed concrete structures. Shrinkage was not greater than that calculated for normal weight concrete of a similar strength class, which will not result in increased loss of prestress. Low creep guarantees low deflection increments over time.
Newly Developed Vanadium-Based Glasses and Their Potential for Nuclear Radiation Shielding Aims: A Monte Carlo Study on Gamma Ray Attenuation Parameters
Authors: Tekin Huseyin Ozan , Bilal Ghaida , Zakaly Hesham M. H. , Kilic Gokhan , Issa Shams A. M. , Ahmed Emad M. , Rammah Yasser Saad , Ene Antoaneta
Published: July 2021

This study aimed to investigate different types of glasses based on the 46V2O5-46P2O5-(8-x) B2O3-xCuO system in terms of their nuclear radiation shielding properties. Accordingly, five different CuO-doped vanadate glasses were investigated extensively to determine the necessary gamma shielding parameters along with effective conductivity at 300,000 and buildup factors. Phy-x PSD software was used for determination of these vital parameters. Furthermore, these parameters, such as half value layer, tenth value layer, and mean free path were investigated in a broad energy range between 0.015 and 15 MeV. The results revealed that the amount of CuO reinforced in each sample plays an essential role in determination of the shielding abilities of the samples. The sample with the highest CuO content had the highest linear attenuation coefficient and mass attenuation coefficient values. Additionally, the lowest mean free path, half value layer, and tenth value layer values were recorded for glass sample VPCu8. There was an inverse relation between the effective conductivity and effective atomic number and photon energy; that is, as energy increases, the effective conductivity and effective atomic number decreased rapidly, especially in the regions of low energy. Glass sample VPCu8 reported the highest values for both parameters. Moreover, glass sample VPCu8 had the lowest exposure buildup factor and energy absorption buildup factor values. Our findings showed that CuO-reinforced vanadate glass composition, namely 46V2O5-46P2O5-8CuO, with a glass density of 2.9235 g/cm3, was reported to have superior gamma ray attenuation properties. These results would be helpful for scientists in determining the most appropriate additive rare earth type, as well as the most appropriate glass composition, to offer shielding characteristics similar to those described above, taking into consideration the criteria for usage and the needs of the community. The results of this research will be useful to the scientific community in evaluating the prospective characteristics of CuO-doped glass systems and related glass compositions. CuO-doped glass systems and associated glass compositions have a wide range of properties.
On the Convergence of a New Family of Multi-Point Ehrlich-Type Iterative Methods for Polynomial Zeros
Authors: Proinov Petko D. , Petkova Milena D.
Published: July 2021

In this paper, we construct and study a new family of multi-point Ehrlich-type iterative methods for approximating all the zeros of a uni-variate polynomial simultaneously. The first member of this family is the two-point Ehrlich-type iterative method introduced and studied by Trićković and Petković in 1999. The main purpose of the paper is to provide local and semilocal convergence analysis of the multi-point Ehrlich-type methods. Our local convergence theorem is obtained by an approach that was introduced by the authors in 2020. Two numerical examples are presented to show the applicability of our semilocal convergence theorem.
Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial
Authors: Nagarathna Raghuram , Kumar Saurabh , Anand Akshay , Acharya Ishwara N. , Singh Amit Kumar , Patil Suchitra S. , Latha Ramesh H , Datey Purnima , Nagendra Hongasandra Ramarao
Published: July 2021

Background: Dyslipidemia poses a high risk for cardiovascular disease and stroke in Type 2 diabetes (T2DM). There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Methods: Here, we report the results of lipid profile values of 11,254 (yoga 5932 and control 5322) adults (20–70 years) of both genders with high risk (≥60 on Indian diabetes risk score) for diabetes from a nationwide rural and urban community-based two group (yoga and conventional management) cluster randomized controlled trial. The yoga group practiced a validated integrated yoga lifestyle protocol (DYP) in nine day camps followed by daily one-hour practice. Biochemical profiling included glycated hemoglobin and lipid profiles before and after three months. Results: There was a significant difference between groups (p < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. Further, the regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Conclusion: Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities.
Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study
Authors: Okumatsu Koki , Yamauchi Hideko , Kotake Rina , Gosho Masahiko , Nakata Yoshio
Published: July 2021

Background: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study. Recruited patients consisted of those receiving endocrine therapy and those not receiving endocrine therapy. Weight at diagnosis was collected from medical records, and current body mass was measured using a digital scale (time since diagnosis was 4.0 ± 1.9 years). Moreover, we measured current physical activity using an accelerometer and dietary intake using a validated questionnaire. The primary analysis was a t-test for the body-mass change after diagnosis between the two groups. Results: We recruited 300 patients and collected data from 292. Mean weight gain after diagnosis was 1.3 ± 3.9 kg, and the change in body mass of patients taking endocrine therapy (1.3 ± 4.0 kg) was not significantly different from that of patients not taking endocrine therapy (1.4 ± 3.8 kg, p = 0.92). There was no association of endocrine therapy, physical activity, and dietary intake with a 5% weight gain after adjusting confounding factors (e.g., breast cancer stage and chemotherapy). Conclusions: Caution is required with generalization because of sampling bias and ethnic differences.