bluuebunny/crossref_metadata_2025 huggingface dataset:
Sm-Co ALLOYS COERCIVITY PREDICTION USING STACKING HETEROGENEOUS ENSEMBLE MODEL
Authors: Trostianchyn Andrii , Duriagina Zoia , Izonin Ivan , Tkachenko Roman , Kulyk Volodymyr , Pavliuk Olena
Published: December 2021

The use of machine learning tools in modern materials science can significantly reduce the duration and cost of developing new materials and improving the properties of existing ones. This is especially true in studying expensive and strategic importance materials like alloys of rare earth metals, which are used to manufacture high-energy permanent magnets. At the same time, single machine learning algorithms do not always provide the accuracy required to solve a particular applied task. Therefore, the current paper aimed to develop an ensemble model for predicting the magnetic properties of Sm-Co system alloys with high accuracy. Based on literature data, we have collected the dataset of the relationship between phase composition, sample state, crystallographic orientation, microstructure, and magnetic properties. We have compared different machine learning algorithms. A stacking ensemble model was designed based on high-precision machine learning algorithms: Neural Networks, AdaBoost, Gradient Boosting, and Random Forest algorithm. The proposed ensemble scheme showed a significant increase in the accuracy for predicting the magnetic properties of Sm-Co alloys on the example of coercivity.
¿No hay nada oculto bajo el sol? El financiamiento de terceros en arbitraje y las obligaciones de revelación bajo el ordenamiento jurídico del Ecuador
Authors: Larrea Savinovich Andrés , Alarcón Peralta Juan Martín
Published: December 2021

El financiamiento de terceros (FPT) o también conocido como Third Party Funding es una figura que ha ganado un espacio importante en el arbitraje internacional en la última
década. Esencialmente, el FPT implica que un tercero, ajeno al proceso, decide financiar a una de las partes, en todo o en parte, los costos y gastos relacionados con el arbitraje a cambio de un beneficio económico. Si bien el FPT no es un mecanismo nuevo en Estados Unidos o Europa para garantizar el acceso a la justicia, en América Latina ha aumentado su popularidad en los últimos años y, cada vez más, resulta común encontrarse con arbitrajes en los que participa un financista. En el Ecuador, esta figura aún resulta extraña y novedosa para muchos. Además, la Ley de Arbitraje y Mediación no hace referencia a los financistas en arbitraje ni a las obligaciones de las partes que reciben financiamiento de terceros. Sin embargo, con el incremento de arbitrajes en los que una de las partes cuenta con el respaldo de un financista vale preguntarse: ¿Tienen las partes la obligación de revelar su situación frente a los árbitros? ¿Existe alguna obligación legal de revelación bajo el ordenamiento jurídico ecuatoriano? Este artículo explora la figura del financiamiento de terceros en arbitraje y las obligaciones de revelación bajo las leyes domésticas.
Viabilidad del Stare Decisis en el Arbitraje Nacional ecuatoriano: Navegando entre puntos conciliables
Authors: Almeida Vintimilla Gabriel Eduardo
Published: December 2021

Viabilidad del Stare Decisis en el Arbitraje Nacional ecuatoriano: Navegando entre puntos conciliables
DEMYSTIFYING THE IMPLEMENTATION OF FLEXIBLE LEARNING STRATEGIES ON INFORMATION SYSTEMS STUDENTS AMIDST THE GLOBAL PANDEMIC
Authors: Mark Van M. Buladaco
Published: December 2021

Many countries worldwide are affected, and there is a fear of losing this whole enduring semester or even more in the coming future. Flexible learning state of being in which learning and teaching are gradually autonomous since the boundaries of the time, place, and study pace are limited. The students enrolled within the Bachelor of Science in Information Systems (BSIS) program in Davao del Norte State College (DNSC) in the first semester of 2020-2021 are the main target of this study in how they follow and adapt the new-normal way of delivering instructional materials. This study used the quantitative approach under the descriptive research design method with the survey questionnaire as the primary data collection tool. Data gathering was done through the use of questionnaires in the form of an online survey.
The total population size of prospective respondents qualified in this study 226 students from Davao del Norte State College, Panabo City during the academic year 2020-2021 amid a pandemic enrolled in the program of BSIS. The coherent response to higher education dynamics, such as the need for technological innovation to adapt flexible learning. Relying on its resilient and innovative spirit, DNSC finds ways to continue delivering its essential new way of giving academic quality to the scholars. Flexible learning uses online and offline modalities and allows completion of scholars learning off-campus. Based on the findings, it can be assumed that the respondents, the Davao del Norte State College (DNSC), the current status of BSIS students are equipped with needed technologies and adjusted to flexible learning.
KEYWORDS: Flexible Learning, Global Pandemic, Information Systems, Davao del Norte State College, Philippines
EXPLORING THE STUDENTS' EXPERIENCE IN LEARNING LITERATURE: CHALLENGES OF CONTEXTUALIZATION
Authors: Jennifer D. Suganob  , Elleine Rose A. Oliva
Published: December 2021

This qualitative-phenomenological study aimed to explore the lived experiences of the Senior High School students in region 11, particularly their learning experience in contextualizing literature. This inquiry was gleaned from Vygotsky, Brunner, and Dewey (1997). Employing the sampling technique, snowball sampling, five (5) students were selected for the in-depth interview. Another five (5) students were selected for the focus group discussion with ten (10) students from five regions’ schools. As to the participants’ lived experiences in learning literature, the following four (4) significant themes emerged: Enjoying the familiarity of content, participating in discussions, developing knowledge expansion, and using familiar examples as learning guides. For the students’ perspective in situations that influence the challenges in contextualization, the following five (5) majors emerged: Listening carefully to the teacher, participating actively during classwork, acquiring life-long lessons, giving participation opportunities for community-based programs, and employing teaching materials. Finally, the students’ perspectives on overcoming contextualization issues were organized into three (3) primary themes. Improved knowledge through contextualization, effectively employing contextualization and learning to study well. The findings of this study are essential for academic institutions to comprehend students’ contextualization experiences.
KEYWORDS:Contextualization, qualitative phenomenological study, thematic analysis, region 11, Philippines
SELF-IMAGE AND STUDENT TEACHING PERFORMANCE OF COED SENIORS
Authors: Lorna D. Capito
Published: December 2021

The study was conducted at the Eastern Samar State University Main Campus during the second semester of the school year 2018 to 2019. It aimed to determine the self-image of the respondents in terms of their positive self-image and negative self-image . It also intended to describe their student teaching performance in terms of their average grade in Student Teaching in the Elem/Sec Schools subject; and to determine whether there is significant relationship between these variables.. Likert-type questionnaire was used to gather data as well as secondary data and employed both Descriptive and Inferential statistics for the analysis of the gathered data..
The findings of the study revealed that the respondents’ perception of their level of positive self-image result to an aggregate mode of 13 which is interpreted as ‘high level’ while their level of negative self-image resulted to an aggregate mode of 14 which is interpreted as ‘ low level’ It also reflected that 95.6% or majority of the senior students were excellent in their teaching performance. Further results reflected that there was no significant relationship between the respondents’ level of positive and negative self-image and their student teaching performance . Hence the null hypothesis was accepted.
The results of the study implied that the respondents’ total level of positive subjective perception of themselves, including the image of their body and impression of their own personality and capabilities are high and that they have developed the necessary skills for teaching as reflected in their student teaching performance. These findings also imply that although the respondents’ level of positive self-image is high, it does not influence their student teaching performance and outlook and preparedness towards the teaching profession.
KEYWORDS: self-image, student teaching performance
A proposed learning environment framework for virtual care
Authors: Liu John , Buckley Heather , Ho Kendall , Hubinette Maria , Abdalkhani Arman , Holmes Cheryl , Nathoo Nawaaz
Published: December 2021

The way in which health care is delivered has rapidly changed since the onset of the COVID-19 pandemic, with a rapid increase in virtual delivery of clinical care. As a result, the learning environment (LE) in health professions education, which has traditionally been situated in the bricks-and-mortar clinical context, now also requires attention to the virtual space. As a frequently examined topic in the health professions literature, the LE is a critical component in the development and training of future healthcare professionals. Based on a published conceptual framework for the LE from Gruppen et al. in 2019, a conceptual framework for how the LE can manifest through virtual care space is presented here. The four components of personal, social, organizational, physical/virtual spaces are explored, with a discussion of how they can be integrated into virtual care. The authors provide suggestions that health professions educators can consider when adapting their LE to the virtual environment and highlight aspects of its integration that require further research and investigation.
Nationaler Lohnschutz? Bemerkungen zur Ablehnung des Rahmenabkommens
Authors: Notter Markus
Published: December 2021

Der Kampf um wirksame Lohnschutzmassnahmen kann nur im europäischen Kontext erfolgreich sein. Eine «Immunisierung» der schweizerischen Lohnschutzmassnahmen gegenüber der europäischen Rechtsentwicklung ist aus dieser Sicht keine sinnvolle Forderung.
Rapport Management in President Buhari and Governor Sanwo-Olu’s Speeches on #EndSARS Protest in Nigeria
Authors: Akinwotu Samuel Alaba
Published: December 2021

Speech making in politics is an essential tool used to manage relationships between politicians and the electorate. The success of a speech depends on the content and the discourse and linguistic strategies employed to achieve speakers’ communicative goals. Political speeches have been widely studied, but extant studies have given tangential attention to the management of rapport in speeches of political office holders delivered in crisis situation in Nigeria. Two speeches delivered by President Muhammadu Buhari (PMB) and Governor Babajide Sanwo-Olu (GBS) on the #EndSARS protests in Nigeria, downloaded from www.guardian.ng and www.premiumtimesng.com respectively, were purposively selected and analysed using Rapport Management theory. This is with the view to accounting for the linguistic elements and discourse strategies and their functions in maintaining harmonious relationship in selected texts. Linguistic elements such as the inclusive “we”, the institutional “I”, collective/possessive “us” “our” “your” and descriptive adjectives and strategies such as claiming common ground, expressing solidarity, showing empathy were employed to manage rapport and achieve communicative goals by PMB and GBS. While GBS tactically avoids utterances that are rapport threatening, some utterances of PMB have the tendency to impair rapport. He however mitigates them through hedging, personalisation, institutionalisation and testimonial argument.
Factors affecting students’ intentions to use a university bus: Importance of travel attitudes and service quality attributes
Authors:   Department of Civil and Environmental Engineering, University of Nizwa, Birkat-al-Mouz, 616, Nizwa, Oman, Javid Muhammad Ashraf , Al-Kasbi Ghadeer Hamed ,   Department of Civil and Environmental Engineering, University of Nizwa, Birkat-al-Mouz, 616, Nizwa, Oman
Published: December 2021

This paper aims to assess the student’s perceptions concerning to characteristics of a university bus service and private car. A questionnaire was designed consisting of personal and travel characteristics of the respondents, respondent's responses on the importance of various service qualities attributes, and mode choice characteristics. The total collected samples were 314 comprising of university students. The relaxed traveling, travel time saving, safety and privacy, and freedom and flexibility in traveling are significant characteristics of travel alternatives. Most of the students believe that traveling in a car gives them more freedom and flexibility in traveling. Traveling in a car is expensive, and students feel happy and relaxed while traveling on a university bus as compared to a car. Car-oriented and bus-oriented attitudes are also significant in determining the students’ intentions toward the university bus service considering their pro-social elements. These findings will help make improvements in the bus service seeking the students’ preferences.
Inappropriate antibiotic use for respiratory infections in outpatient settings
Authors: Omer Saman , Khan Bushra Tayyaba , Jalil Omer , Khan Muhammad Waqar Aslam , Mehdi Quratulain , Sharif Mahjabeen
Published: December 2021

Background: Overuse of antibiotics is a significant problem in low- and middle-income countries where recommended treatment guidelines are not routinely practiced, resulting in antimicrobial resistance. Acute respiratory tract infections, mostly viral in origin, remain the clinical category for most commonly prescribed antibiotics. Due to the lack of local evidence about antibiotic prescribing trends in such infections, this study was conducted to evaluate the prescribing patterns in general and antibiotic prescribing trends specifically in prescriptions with the diagnosis of acute respiratory infections in district Mirpur of Azad Kashmir.

Patients and methods: A prospective cross-sectional study carried out in the Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi, and outpatient departments of public health facilities in district Mirpur, Kashmir, from Aug to Oct 2020. Data were collected from 10 different public health facilities in District Mirpur, Kashmir including, three rural health centers (RHC) and five basic health units (BHU). Prescribing pattern analysis by objective observations of the prescriptions after patient-physician encounter against the World Health Organization defined core prescribing indicators. The appropriateness of antibiotic use was analyzed against clinical practice guidelines. IBM SPSS Statistics for Windows, Version 26 was used for data analysis. Descriptive analysis was done to find frequencies and percentages for categorical data and means and standard deviation for continuous data.

Results: Total number of prescriptions evaluated was 144. Number of prescriptions containing antibiotics was 118 (82%) (standard, 20 - 26.8%). Inappropriate use of antibiotics was seen in 78% of cases where no antibiotics were indicated. The average number of medicines per prescription was 3.11 (standard, 2.1), whereas 79% of medicines prescribed were from the national essential medicine list (standard, 100%). Only 2.5% (standard, 100%) of the medications were prescribed with generic names.

Conclusion: This study shows an inappropriate and overuse of antibiotics for acute respiratory tract infections, indicating a lack of adherence to core prescribing indicators and clinical guidelines by the physicians in outpatient clinics of Mirpur.
Diagnostic accuracy of toluidine blue in early detection of oral squamous cell carcinoma
Authors: Chishty Muhammad Salman , Sajid Malik Ali Hassan , Younus Shoaib - , Haq Usman Ul
Published: December 2021

Background: Indian sub-continent (India, Pakistan, and Bangladesh) is one of the high-risk populations for oral cancer cases. Intraoral screening is critical to diagnosis and treating oral cancer at an early stage for a better prognosis. Among the diagnostic adjuncts, toluidine blue staining is considered a simplistic, cost-effective, and highly sensitive method. The objective of the current study was to find out the diagnostic accuracy of toluidine blue in the early detection of oral squamous cell carcinoma.

Patients and methods: This prospective observational study was undertaken at the Department of Oral and Maxillofacial Surgery, Institute of Dentistry, CMH Lahore Medical College from15-09-2019 to 15-03-2020 after getting approval from IRB.  Based on inclusion criteria, a sample size of 100 was calculated and enrolled in the study. Non-probability convenient sampling technique was utilized. Oral staining of 100 patients was done with 1% toluidine blue on an OPD basis, and incisional biopsies were then performed. Staining pattern and histopathology reports of patients were evaluated to assess the diagnostic accuracy

Results: The study results revealed the sensitivity of Toluidine Blue as 89.87%, and specificity of toluidine blue was found as 76.19%. Positive and negative predictive values of Toluidine Blue remained 93.42% and 66.67%, respectively.

Conclusion: Toluidine blue has good diagnostic accuracy for early detection of oral squamous cell carcinoma (SCC).
Формування духовності зростаючої особистості в умовах соціалізуючих викликів сучасності
Authors: Бордюк Володимир , Ковбасюк Тетяна
Published: December 2021

У статті висвітлено підходи щодо формування духовності особистості. На основі аналізу наукових праць схарактеризовано феномен духовності як свідчення єднання людини з Високим, духовним, Божественним та абсолютним. Окреслено основні напрями вивчення духовності особистості: філософсько-релігійний як пробудження внутрішньої дійсності людини, її душі, прагнення об’єднатися з вищою дійсністю і перетворитися у нову особистість; культурологічний як процес олюднення, окультурення людини; психолого-педагогічний, в основі якого освітня діяльність розглядається як процес складання духовного світу особистості; соціально-психологічний як вищий прояв внутрішнього світу особистості, що виявляється в людяності, сердечності, доброті, щирості, чесності, відкритості для інших людей, широті поглядів, ерудиції, культурі, загальному розвитку особистості, інтелігентності та що утворює її духовний потенціал; психологічний, завдяки якому духовність представлена як людська якість, що спрямовує особистість до самопізнання, самовдосконалення, творчого розвитку, гуманістичної поведінки.

Визначено сутність духовності як мети й досягнень людини, результату її цілеспрямованих зусиль. Основну увагу закцентовано на тому, що людина має як фізичну складову, так і духовну, зокрема в контексті розкриття проблеми змодельовано структуру людської душі у вигляді трьох складових: душі розумної (голова), душі емоцій і почуттів (серце), душі потягів та пристрастей (сідалище). Обґрунтовано вплив духовності на розвиток сучасного мистецтва. Доведено, що саме в духовності особистості закладена основа самореалізації в усіх її виявах (пізнавальна, моральна, естетична, самоосвітня, самопізнавальна, самовиховна, комунікативна), а головною умовою розвитку духовності особистості є її любов до інших людей.
Формування громадянської відповідальності як складової громадянської компетентності здобувачів освіти закладу загальної середньої освіти
Authors: Паніна Лариса , Авдимирець Лілія
Published: December 2021

У статті розглянуто питання формування громадянської відповідальності як складової громадянської компетентності в здобувачів освіти закладу загальної середньої освіти. Здійснено аналіз нормативних та наукових джерел, розкрито поняття громадянської, соціальної компетентності та громадянської відповідальності. Громадянську і соціальну компетентності визначено як ключові компетентності Нової української школи. Проаналізовано методи, що сприяють формуванню громадянської відповідальності та громадянської позиції учнів у закладу загальної середньої освіти. Визначено сутнісні характеристики громадянської відповідальності особистості та взаємозв’язок і взаємообумовленість громадянської відповідальності із соціально-духовним становленням особистості. Проаналізовано чинники, які мають вплив на становлення громадянської відповідальності здобувачів освіти закладу загальної середньої освіти.
Марко Кропивницький та українська музична культура (за матеріалами музею театрального, музичного та кіномистецтва України)
Authors: Кармазін Антон
Published: December 2021

У статті окреслено музичну сторону діяльності письменника, драматурга, театрального режисера та актора Марка Лукича Кропивницького, що певною мірою знаходиться в тіні його літературних і театральних здобутків, однак є не менш цікавою та насиченою, про що свідчать експонати Музею театрального, музичного та кіномистецтва України. Драматурга представлено не лише як непересічного музиканта та співака, в репертуарі якого було чимало українських народних пісень, оперних арій, романсів, а й читця та диригента хору. Марка Кропивницького схарактеризовано як особистість із багатими музичними та вокальними даними, яскравим акторським талантом, які під час перегляду театральних постановок викликали справжнє захоплення в глядачів. Оригінальні авторські композиції та український фольклорний матеріал складали основу музичного рішення вистав трупи Кропивницького, які він здійснював самостійно як режисер та композитор. Представлено артефакти Музею театрального, музичного та кіномистецтва України, зокрема унікальні матеріали, афіші, рукописи, що свідчать про активну діяльність Кропивницького як музиканта.
A contribuição da análise fenomenológica nos estudos de relato de caso
Authors: Naudin Jean , Fromer Alice , Fernandes Flávio Guimarães
Published: December 2021

A psiquiatria clínica oscila, segundo nossa argumentação, entre dois polos epistemológicos: inferência e percepção. A abordagem inferencial categoriza o transtorno como que de baixo para cima, isto é, partindo dos sintomas visíveis para a categoria patológica que supostamente os causa. Ao fazê-lo, distanciamo-nos de uma percepção mais instantânea que se possa ter acerca do paciente, assim como da consideração do transtorno enquanto fenômeno mutável, passível de evolução. De um ponto de vista fenomenológico, o modelo perceptivo permite que o terapeuta, em meio ao encontro, possa experienciar o emergir de uma impressão global acerca do paciente. Graças à épochè, faz-se possível emergir um senso de totalidade, uma Gestalt. Ora, o caso clínico, ainda assim, é sempre uma construção, uma narrativa intersubjetiva sobre o transtorno, narrativa essa recontada pelo paciente. Reunir casos clínicos pode levar-nos ao desenvolvimento de casos “tipo”, em que cada um deles se torna uma referência com a qual poderão ser realizadas comparações e categorizações, já que pertencem a uma “familiaridade” clínica; tal como os particulares, se quisermos referir-nos à teoria platônica das essências (Eidos). A abordagem fenomenológica contribui para a experiência clínica na medida em que possibilita a relação entre percepção e inferência, entre experiência subjetiva e narrativa intersubjetiva e entre pessoa e tipo.
Immunotherapy in head and neck squamous cell carcinoma and rare head and neck malignancies
Authors: Cavalieri Stefano , Filippini Daria Maria , Ottini Arianna , Bergamini Cristiana , Resteghini Carlo , Colombo Elena , Lombardo Roberta , Nuzzolese Imperia , Alfieri Salvatore , Licitra Lisa , Locati Laura D.
Published: December 2021

The dismal prognosis of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) prompted recent advances in the field of therapeutic approaches beyond cytotoxic cancer therapy. In recent years, the deeper and increasing knowledge on the genomic landscape and the upcoming new data on immunotherapy enacted by HNSCCs have led to successful therapeutic targeting of the immune system. Immune checkpoint inhibitors (ICIs) have changed state of the art in R/M patients and could have a potential role even in early disease. The purpose of this work is to summarize the role of immunotherapy for R/M HNSCC in clinical practice, with insights about future perspectives. Updated immunotherapy results in other R/M head and neck cancers such as thyroid, salivary glands, nasopharynx, sinonasal cancers, and nuclear protein in testis (NUT) are presented.
The Role of Vitamin D in Metabolic Syndrome in Polycystic Ovary Syndrome
Authors: Intisar Younis Mohammed Ibrahim
Published: December 2021

Objective: The aim of this study was to assess the women complaining from polycystic ovary syndromeand the relation of serum vitamin D levels according to the different phenotypes of the disease by aretrospective study.Methods: Records for 242 infertile women diagnosed with PCOS have been examined. In thisretrospective study, 100 of them have been randomly recorded for 4 PCOS phenotypes. 40 normalovulation women with a male factor history were selected as the control group.In four phenotype types including: age, BMIs, the infertility duration, the hormonal profile and theserum vitamin D, the P value of 0.05 was found to be statistically significant.Results: In comparison with PCOS patients (P<0.001), the data showed a serum vitamin D level ofstatistically importance in the control group. Also, four PCOS phenotypes had no significant variation inthe serum vitamin D levels.Conclusions: There were no significant differences between the serum vitamin D levels of the differentPCOS phenotypes. The additional studies of large samples are recommended for determining the roleof the serum vitamin D level in PCOS patients.
The Influence of Safety Management Practices on Safety Performance in Nurses of Emergency Installation on The Government Hospital of Surabaya
Authors: Khaulah Syahidah  , Noeroel Widajati  , Nurhayati Saridewi
Published: December 2021

Introduction: Hospital is one of the high-risk workplaces in terms of safety and health. Nurses arethe most vulnerable health workers to work accidents because they have the most number in a hospitaland most often interact with patients. Safety performance is very important for the prevention of workaccidents. This research aimed to analyze the influence of safety management practices on safetyperformance in nurses of the emergency installation at X Hospital of Surabaya.Methods: This research was an observational research with the cross-sectional design. It was conductedin May to June 2019. The population in this study was 208 nurses and the sample obtained using asimple random sampling technique involving 68 nurses. In assessing safety management practices andsafety performance, the researcher used questionnaires, observation, and interviews.Results: The results presented that safety training which was a dimension of safety managementpractices affected on the safety performance with a p-value 0.000. Suggestions in this research, toimprove safety performance, management can conduct specific and periodic safety training, holdingsafety briefing and safety talk on a regular basis, and implementing a safety award by applying a systemof reward and punishment.Conclusion: Hospital management still needs to schedule a specific and periodic safety training fornurses. Furthermore, to improve safety performance, management can holding safety briefing andsafety talk on a regular
Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer’s Disease
Authors: Leon Agung Manurung  , Widiana Ferriastuti  , Bambang Soeprijanto  , Hartono Yudi Sarastika
Published: December 2021

Magnetic Resonance Imaging (MRI) is the standard imaging evaluations in Alzheimer’s Disease (AD).Information regarding hippocampus and entorhinal cortex sizes plays an important role in Alzheimer’sdisease. This study aims to determine hippocampal volume and entorhinal cortex thickness inAlzheimer’s disease obtained from a group of patients who underwent head MRI.This study was an observational study with retrospective approach in patients who were diagnosedwith AD and had available head MRI examination results. A total of 14 patients were diagnosed by aneurologist with AD using MMSE, Hachinsky, and NIA-AA criteria.From head MRI measurement in AD patients, we found that the mean volume of right, left, andtotal hippocampal was 1700±0.395 cm3; 1.670±0.349 cm3; and 3.370±0.725 cm3, respectively. Themean thickness of right, left, and total entorhinal cortex was 1.821±0.459 mm; 1.463±0.369 mm; and3.285±0.791 mm, respectively. There is a possible difference between the early and late stages of AD inthe same patient. Further studies with larger cohorts are needed to examine these correlations.
Production and Purification of aflatoxin b1 from Local Isolate of Aspergillus flavus
Authors: Mohammed Abdullah Zayer  , Rafid Abdalwahd  , Essam Fadel al-jumaili
Published: December 2021

Background and Objective: Aflatoxins are cancerogenic compounds produced predominantly by certain strains of the Aspergillus genus. Food and feed contamination by aflatoxin (AF)B1 has adverse economic and health consequences. Unfortunately, these contaminants can never be completely removed, and on that account, many studies have been carried out to explore an effective process of their detoxification to a threshold level. Results: A thermostable enzyme purified from the boiled supernatant was designated as Horseradish aflatoxin-degrading enzyme (HADE). An overall 9.55-fold purification of HADE with a recovery of 39.92% and an activity of 3.85 × 103 U·mg−1 was obtained using chromatography on DEAE-Sepharose. peroxidase had an estimated molecular mass of 34 kDa and exhibited the highest activity at 25 °C and pH 7.0. peroxidase is the major protein involved in AFB1 detoxification. Conclusion: PTLC It is reliable as it is a good and reliable method for separating compounds and toxins. It is necessary to study the other compounds that the Aspergillus fungus secretes, as they are likely to cause harms more dangerous than aflatoxin B1.
OPTIMALISASI PELAYANAN BINA KOMUNIKASI MELALUI PROGRAM PERSEPSI BUNYI DAN IRAMA (BKPBI), UNTUK ANAK YANG BERKEBUTUHAN KUSUS TUNARUNGGU DI SDLB NEGERI JENANGAN PONOROGO
Authors: Suhartini Endang , Murdianto Murdianto , Setyowati Nanik
Published: December 2021

Children with special needs are children with different characteristics from normal children in general. Especially deaf children are children who have impaired hearing either totally or have residual hearing. Deaf communication requires services that can support their communication difficulties. In this case SDLB Negeri Jenang Ponorogo organized a communication development program with Communication Development through the Sound and Rhythm Perception Program (BKPBI). In this study the author is intended to discuss more about; Forms of service stages, learning implementation strategies and service results of sound and rhythm perception programs in SDLB Negeri Jenang Ponorogo. This research uses a qualitative approach methodology with the type of case study research. The data in this study are words and actions, while the source of the data are the Principal and teachers at SDLB Negeri Jenang. Data collection methods are interviews, observation, and documentation. Data analysis techniques using data reduction, data presentation, and drawing conclusions. After conducting the analysis, the writer can conclude that the form of communication service development stages through sound and rhythm perception programs in the Jenang Negeri Extraordinary Elementary School is sound detection, sound discrimination, sound identification, sound comprehension, learning implementation strategies using review, overview, presentation, exercise, and summary, also by using the classical and individual models, while the results of the service program of perception of sound and rhythm in the State Elementary School Extraordinary, namely deaf children are able to recognize sounds, easy to respond to sounds such as background noises, the nature of sounds, creating sounds up to recognize types of musical instruments, able to identify sounds and detect the direction of sound.
Implementasi Pembelajaran Multimedia Interaktif Untuk Meningkatkan Semangat Belajar Anak Pada Kelurahan Sungaisibam
Authors: Khusnul Fikri  , Bagas Tri Ramadana
Published: December 2021

Saai ini dunia sedang menghadapi pandemi global covid-19 yang mengakibatkan banyak aspek yang terdampak oleh wabah ini. Salah satu aspek yang berdampak yaitu aspek pendidikan, dimana masyarakat dituntut untuk mengurangi kegiatan diluar rumah serta proses tatap muka belajar di sekolah dilakukan secara daring/online. Berdasarkan hasil survei yang telah dilakukan permasalahan yang dihadapi antara lain : (1) Berkurangnya semangat belajar anak-anak (2) Anak-anak lebih cenderung lebih sering bermain game pada smartphone. Solusi yang dihadirkan dengan membuat media pembelajaran berbasis multimedia interaktif. Multimedia interaktif merupakan suatu multimedia yang dilengkapi dengan alat pengontrolan  yang dapat dioperasikan oleh pengguna, sehingga pengguna dapat memilih apa yang dikehendaki untuk proses selanjutnya. Multimedia interaktif yang dibuat dikemas dalam bentuk android yang dibuat dengan memanfaatkan software Microsoft Office Power Point 2016, iSpring Suite 10, dan Web 2 APK. Berisi materi Pendidikan Agama, Pendidikan Karakter, dan Pendidikan Kreativitas dilengkapi juga video pembelajaran dan kuis. Penelitian ini bertujuan untuk : (1) Meningkatkan semangat belajar anak-anak pada RW 01 Kelurahan Sungaisibam, (2) Membuat aplikasi Multimedia Interaktif berbasis Android, dan (3) Melakukan pendampingan belajar guna mengoptimalkan pembelajaran berbasis online.
Microplanning and Language Policy in Morocco
Authors: MOUMMOU Aziz
Published: December 2021

Language policy and planning (LPP) has undergone an epistemological turn. Early LPP works approached linguistic diversity as a problem; especially for the newly independent states, but in today’s globalized world, multilingualism is the norm. A major issue that characterizes contemporary LPP in Morocco and needs further investigation is the interaction between macro-policies and local practices. Most top down language policies face resistance from speech communities. The purpose of this paper is to illuminate the role of micro-planning and local agents in implementing a workable language policy. The aim is to reduce the gap between LPP research and local practices by using an ethnographic approach. Ruiz orientational model and Spolsky’s management theory provide a rich theoretical framework. Micro-planning can translate central policies into local practices.
Les enjeux de la formation continue des enseignants dans les Centres Régionaux des Métiers de l’Education et de la Formation (CRMEF) au Maroc
Authors: MILI Abdesselam , EROUIHANE Jaouad , TOUBI Lahcen
Published: December 2021

La formation continue des enseignants au Maroc a pris des formes multiples et diversifiées sur le plan organisationnel et fonctionnel. Aussi le recours à la formation continue reste-t-il, malgré tout, faible et n’atteint généralement pas les résultats escomptés. Actuellement, les CRMEF[1] sont les seules entités chargées de la formation du personnel du MEN[2] (enseignants, administrateurs, techniciens…). Cette mission, parmi d’autres, attribuée aux CRMEF est dans sa phase d’implémentation. En effet, la formation continue des enseignants, qui constitue la mission phare des CRMEF, n’a pas encore pris l’élan qu’il faut. S’agit-il d’un blocage institutionnel, financier, ou pédagogique ? Rappelons que, selon le décret en vigueur, les CRMEF et les AREF[3] doivent coordonner entre eux pour réaliser cette mission. Or, il est plus facile de dire que de faire. Nous allons montrer à travers l’expérimentation du dispositif de formation continue de la langue française durant l’année scolaire 2014/2015, l’importance de la prise en compte de certaines dispositions notamment : la qualité du dispositif de formation, le type de motivation attendu par les bénéficiaires, le processus de changement des représentations des concernés, pour garantir une formation qui pourrait avoir un impact positif sur le système. La nature de la nouvelle formule de formation est permanente, hebdomadaire et assurée au CRMEF selon un créneau horaire négocié.

 

[1] Les centres régionaux des métiers de l’Education et de la Formation.

[2] Ministère de l’Education Nationale et de la Formation professionnelle.

[3] Académie Régionale de l’Education et la Formation.
Digestive disorders induced by the accumulation of arsenic in the human body
Authors:   Universitatea de Medicină și Farmacie „Carol Davila“, București, România, EPURE Alina , CHEȚA Dan Mircea ,   Universitatea de Medicină și Farmacie „Carol Davila“, București, România,   Institutul Național de Diabet Zaharat, Nutriție și Boli Metabolice „N.C. Paulescu“, București, România
Published: December 2021

Exposure to arsenic is common, but unconscious, inducing major imbalances especially in the digestive tract, lungs, skin. Contamination is achieved by exposure to arsenic in the air, soil, groundwater, food. It is noted the use of arsenic in pesticides, herbicides, paints, wood preservatives, drinking water, various foods with a wide range of consumption (seafood, rice – including rice milk, rice bran, rice cereals, rice syrup rice, rice crackers). The diagnosis of arsenic poisoning is an important step in establishing the diet and detoxification treatment, focusing on the cause, not the symptoms. We present the case of a 45-year-old patient with symptoms manifested in the digestive tract for 4 years: abdominal bloating, cramps, vomiting, weekly episodes of acute diarrhea. During these period the patient received multiple treatments depending on the symptoms, without a significant improvement, without performing specific investigations of arsenic poisoning. The personalized diet and treatment plan, used in the case of this patient, for a period of 4 months was distinguished by a total solution of the manifestations presented in the anamnesis stage.
Utility of topic agents in post cervical uterine fibroids removal
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest,Romania, BACALBASA Nicolae ,   Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, Bucharest, Romania, BALESCU Irina ,   Department of Visceral surgery, ”Ponderas” Academic Hospital, Bucharest, Romania, ALOUL Adnan Ad ,   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania,   Department of Surgery, “Titu Maiorescu“ University, Bucharest, Romania, BOHILTEA Roxana ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest,Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, SOCEA Bogdan ,   Department of Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Surgery, ”Sf. Pantelimon” Clinical Emergency Hospital, Bucharest, Romania, URSUT Bogdan ,   Department of Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Surgery, ”Agrippa Ionescu” Clinical Emergency Hospital, Bucharest, Romania, FILIPESCU Alexandru ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest,Romania,   Department of Obstetrics and Gynecology, ”Elias” Emergency Hospital, Bucharest, Romania
Published: December 2021

Uterine fibroids represent the most commonly encountered uterine tumors in women worldwide which can develop at the level of any segment of the uterus and can pose different problems in regard to the most appropriate therapeutic strategy especially in young women which deserve fertility preservation. Meanwhile in certain cases they can impede the development of a normal pregnancy due to their location or can show significant enlargement in volume during pregnancy due to the increased blow flow at this level. In all cases in which they induce the apparition of symptoms or impede the apparition or development of a normal pregnancy they should be removed. In cases in which the fibroids are located at the level of the uterine cervix attention should be focused on providing a correct and efficient postoperative healing. The aim of this paper is to review the most important aspects related to uterine cervix fibroid symptoms, treatment and postoperative healing, particular attention being given to Cerviron, a topic agent which seems to provide an efficient healing at this level.
A rare but treatable inborn error of metabolism: Arginine glycine amidinotransferase (AGAT) deficiency
Authors:   Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Pintilie Sebastian Romeo , Fodor Adriana ,   Clinical Center of Diabetes, Nutrition and Metabolic Diseases, Cluj-Napoca, Romania,   Department of Diabetes and Eating Disorders, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Bembea Marius ,   Department of Genetics, Faculty of Medicine and Pharmacy, University of Oradea, Romania,   ”Dr. Gavril Curteanu” Municipal Clinical Hospital, Regional Center for Medical Genetics Bihor, Oradea, Romania, Petchesi Codruța Diana ,   Department of Genetics, Faculty of Medicine and Pharmacy, University of Oradea, Romania, Grad Simona ,   Department of Internal Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   2nd Department of Internal Medicine, Emergency Clinical County Hospital Cluj, Cluj-Napoca, Romania, Damian Laura ,   Department of Rheumatology, Center for Rare Autoimmune and Autoinflammatory Diseases, Emergency Clinical County Hospital Cluj, Cluj-Napoca, Romania,   CMI Reumatologie Dr. Damian, Cluj-Napoca, Romania, Vulturar Romana ,   Department of Molecular Sciences, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Cognitive Neuroscience Laboratory, “Babeș-Bolyai“ University Cluj-Napoca, Romania
Published: December 2021

AGAT deficiency is a rare and treatable autosomal recessive disorder. The symptoms are early-onset developmental mild to moderate intellectual disability, delayed speech acquisition, behavioral problems or proximal muscle weakness. Biochemical screening for creatine, creatinine and urinary guanidinoacetate and genetic tests are used for diagnosis. Electromyography may be normal or may have a myopathic pattern with low amplitude polyphasic waves. Muscle biopsy may show abnormalities including small myocytes. Creatine supplementation can fully prevent the neurological disability, if the treatment is started early in life; the muscular function improves irrespective of the supplementation moment.
The role of topic vaginal products in posthysterectomy vaginal atrophy
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, Bucharest, Romania, Balescu Irina ,   Department of Visceral surgery, ”Ponderas” Academic Hospital, Bucharest, Romania, Aloul Adnan Ad ,   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania,   Department of Surgery, “Titu Maiorescu“ University, Bucharest, Romania, Bohiltea Roxana ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Socea Bogdan ,   Department of Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Surgery, ”Sf. Pantelimon” Clinical Emergency Hospital, Bucharest, Romania, Ursut Bogdan ,   Department of Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Surgery, ”Agrippa Ionescu” Clinical Emergency Hospital, Bucharest, Romania, Filipescu Alexandru ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, ”Elias” Emergency Hospital, Bucharest, Romania
Published: December 2021

Vaginal atrophy represents a frequently encountered condition which is significantly correlated with decreased amounts of circulating oestrogen levels. It is usually characterized by the presence of burning, itching, irritation and dyspareunia. In such cases attention was focused on identifying a topic product which might alleviate these symptoms and stop the deterioration process of the vaginal lining. One product which seems to have an effective role in order to stop this process and to offer a good local control of the disease should contain anti-inflammatory, healing and antiseptic principles. The aim of the current paper is to study the possible benefits of Cerviron a topic product with intravaginal administration which contains seven active principles in order to offer the above mentioned effects.
Fetal prognosis in cesarean section
Authors:   Spitalul Județean de Urgență, Slobozia, România, Saba Maria , Nanu Dimitrie ,   Universitatea de Medicină și Farmacie „Carol Davila”, București, România
Published: December 2021

When deciding on a caesarean section, perinatologists should consider the consequences for the newborn. Studies show that caesarean section modifies adaptation to extrauterine life and is associated with risks of neonatal complications. Other determining factors for the condition and future of the newborn (gestational age, the existence of labor before cesarean section, anesthesia etc.) are not to be neglected. This article reviews the elements of the neonatal respiratory adaptation physiology, which are essential to understanding the clinical complications attributed to the mode of birth, and proposes a reconsideration of neonatal morbimortality after cesarean section.
Effects of Dietary Inclusion of Ginger (Zingiber Officinale) and Garlic (Allium Sativum) Oil (GGO) Mixtures on Carcass Characteristics and Sensory Evalaution of Broiler Chickens
Authors: Oluwafemi R. A , Lawal Aisha Omolade , Adetope Adelowo Samad , Alagbe J. O
Published: December 2021

An experiment was conducted to assess the influence of GGO on carcass features and sensory assessment of broiler chickens. 120 1-day-old (Arbo acre) birds were separated into five treatments, each with three replicates of 8 birds. Throughout the 8-week trial, clean feed and water were available at all times. NRC's basal diet was designed to suit avian nutritional needs (1994). A 0% GGO meal was given to the birds in treatment 1, whereas GGO levels of 0.1, 0.2, 0.3 and 0.4 percent were given to the birds in treatments 2, 3, 4, and 5. As well as studying the phytochemical content of (Zingiber officinale) and garlic (Allium sativum) oil, carcass and organ features of birds were also studied. Zingiber officinale contains phenols (8.21%), alkaloids (5.12%), flavonoids (7.49%), tannins (6.52%), saponins (3.18%), streiods (2.38%), glycosides (0.18%), oxalates (0.07%), and phytate (0.07%). (0.02 %). Sativum contains flavonoids (10.67%) alkaloids (7.02%) tannins (4.72%) steroids (3.65%) saponin (2) glycoside (0.33%) oxalates (0.26%) and phytate (0.26%). (0.05 %). Dressing %, carcass and relative organ weights differed across treatments (P0.05). The liver, kidney, spleen, and other internal organs showed no signs of inflammation. GGO altered meat sensory assessment (tenderness, juiciness, taste, and fragrance) except meat color which was not significantly (P0.05) different across treatments. GGO may be fed to broilers up to 0.4 percent without affecting their health or performance.