bluuebunny/crossref_metadata_2025 huggingface dataset:
Microelectrode implantation in motor cortex causes fine motor deficit: Implications on potential considerations to Brain Computer Interfacing and Human Augmentation
Authors: Goss-Varley Monika , Dona Keith R. , McMahon Justin A. , Shoffstall Andrew J. , Ereifej Evon S. , Lindner Sydney C. , Capadona Jeffrey R.
Published: November 2017

Intracortical microelectrodes have shown great success in enabling locked-in patients to interact with computers, robotic limbs, and their own electrically driven limbs. The recent advances have inspired world-wide enthusiasm resulting in billions of dollars invested in federal and industrial sponsorships to understanding the brain for rehabilitative applications. Additionally, private philanthropists have also demonstrated excitement in the field by investing in the use of brain interfacing technologies as a means to human augmentation. While the promise of incredible technologies is real, caution must be taken as implications regarding optimal performance and unforeseen side effects following device implantation into the brain are not fully characterized. The current study is aimed to quantify any motor deficit caused by microelectrode implantation in the motor cortex of healthy rats compared to non-implanted controls. Following electrode insertion, rats were tested on an open-field grid test to study gross motor function and a ladder test to study fine motor function. It was discovered that rats with chronically indwelling intracortical microelectrodes exhibited up to an incredible 527% increase in time to complete the fine motor task. This initial study defines the need for further and more robust behavioral testing of potential unintentional harm caused by microelectrode implantation.
Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice
Authors: Nguyen Philip V. , Wessels Jocelyn M. , Mueller Kristen , Vahedi Fatemeh , Anipindi Varun , Verschoor Chris P. , Chew Marianne , Deshiere Alexandre , Karniychuk Uladzimir , Mazzulli Tony , Tremblay Michel J. , Ashkar Ali A. , Kaushic Charu
Published: November 2017

Approximately 40% of HIV-1 infections occur in the female genital tract (FGT), primarily through heterosexual transmission. FGT factors determining outcome of HIV-1 exposure are incompletely understood, limiting prevention strategies. Here, humanized NOD-Rag1−/−γc−/−mice differentially reconstituted with human CD34+ -enriched hematopoietic stem cells (Hu-mice), were used to assess target cell frequency and viral inoculation dose as determinants of HIV-1 infection following intravaginal (IVAG) challenge. Results revealed a significant correlation between HIV-1 susceptibility and hCD45+ target cells in the blood, which correlated with presence of target cells in the FGT, in the absence of local inflammation. HIV-1 plasma load was associated with viral dose at inoculation and frequency of target cells. Events following IVAG HIV-1 infection; viral dissemination and CD4 depletion, were not affected by these parameters. Following IVAG inoculation, HIV-1 titres peaked, then declined in vaginal lavage while plasma showed a reciprocal pattern. The greatest frequency of HIV-1-infected (p24+) cells were found one week post-infection in the FGT versus blood and spleen, suggesting local viral amplification. Five weeks post-infection, HIV-1 disseminated into systemic tissues, in a dose-dependent manner, followed by depletion of hCD45+ CD3+ CD4+ cells. Results indicate target cell frequency in the Hu-mouse FGT is a key determinant of HIV-1 infection, which might provide a useful target for prophylaxis in women.
Atomistic Structure of Mineral Nano-aggregates from Simulated Compaction and Dewatering
Authors: Ho Tuan Anh , Greathouse Jeffery A. , Wang Yifeng , Criscenti Louise J.
Published: November 2017

The porosity of clay aggregates is an important property governing chemical reactions and fluid flow in low-permeability geologic formations and clay-based engineered barrier systems. Pore spaces in clays include interlayer and interparticle pores. Under compaction and dewatering, the size and geometry of such pore spaces may vary significantly (sub-nanometer to microns) depending on ambient physical and chemical conditions. Here we report a molecular dynamics simulation method to construct a complex and realistic clay-like nanoparticle aggregate with interparticle pores and grain boundaries. The model structure is then used to investigate the effect of dewatering and water content on micro-porosity of the aggregates. The results suggest that slow dewatering would create more compact aggregates compared to fast dewatering. Furthermore, the amount of water present in the aggregates strongly affects the particle-particle interactions and hence the aggregate structure. Detailed analyses of particle-particle and water-particle interactions provide a molecular-scale view of porosity and texture development of the aggregates. The simulation method developed here may also aid in modeling the synthesis of nanostructured materials through self-assembly of nanoparticles.
Limited evidence of declining growth among moisture-limited black and white spruce in interior Alaska
Authors: Sullivan Patrick F. , Pattison Robert R. , Brownlee Annalis H. , Cahoon Sean M. P. , Hollingsworth Teresa N.
Published: November 2017

Boreal forests play critical roles in global carbon, water and energy cycles. Recent studies suggest drought is causing a decline in boreal spruce growth, leading to predictions of widespread mortality and a shift in dominant vegetation type in interior Alaska. We took advantage of a large set of tree cores collected from random locations across a vast area of interior Alaska to examine long-term trends in carbon isotope discrimination and growth of black and white spruce. Our results confirm that growth of both species is sensitive to moisture availability, yet show limited evidence of declining growth in recent decades. These findings contrast with many earlier tree-ring studies, but agree with dynamic global vegetation model projections. We hypothesize that rising atmospheric [CO2] and/or changes in biomass allocation may have compensated for increasing evaporative demand, leaving recent radial growth near the long-term mean. Our results highlight the need for more detailed studies of tree physiological and growth responses to changing climate and atmospheric [CO2] in the boreal forest.
Spontaneous attention-capture by auditory distractors as predictor of distractibility: a study of domestic horses (Equus caballus)
Authors: Rochais C. , Henry S. , Hausberger M.
Published: November 2017

Distractibility (i.e. individual distraction from his ongoing activity) is thoughts to affect daily life. The present study develops an easy way to assess inter-individual variations of distractibility of an animal model, the domestic horse. We developed the ‘distractibility test’ (DT), based on auditory stimuli, a major source of distraction in daily life. We hypothesized that the broadcast of unusual sounds would provide a reliable source of distraction and that the responses to these unusual sounds would yield a good estimation of a horse’s level of distractibility. Validity of the DT was assessed by comparing the subjects’ interest towards the sound in this test to their attentional state in experimental visual attention tasks and in a working task. Our results showed inter-individual differences in response to the stimuli, with consistency over time. The subjects’ responses to this DT were negatively correlated to their attentional skills in separate experimental tests and in a working task. This is to our knowledge the first ‘real-world’ estimate of an animal’s distractibility in its home environment that could potentially be adapted for humans.
A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization
Authors: Ma Wen-Tao , Liu Qing-Zhi , Yang Jing-Bo , Yang Yan-Qing , Zhao Zhi-Bin , Ma Hong-Di , Gershwin M. Eric , Lian Zhe-Xiong
Published: November 2017

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and eventually liver failure. Several mouse models have been used to clarify the pathogenesis of PBC and are generally considered reflective of an autoimmune cholangitis. Most models focus on issues of molecular mimicry between the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitochondrial autoantigen of PBC and xenobiotic cross reactive chemicals. None have focused on the classic models of breaking tolerance, namely immunization with self-tissue. Here, we report a novel mouse model of autoimmune cholangitis via immunization with syngeneic bile duct protein (BDP). Our results demonstrate that syngeneic bile duct antigens efficiently break immune tolerance of recipient mice, capturing several key features of PBC, including liver-specific inflammation focused on portal tract areas, increased number and activation state of CD4 and CD8 T cells in the liver and spleen. Furthermore, the germinal center (GC) responses in the spleen were more enhanced in our mouse model. Finally, these mice were 100% positive for anti-mitochondrial antibodies (AMAs). In conclusion, we developed a novel mouse model of PBC that may help to elucidate the detailed mechanism of this complex disease.
Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia
Authors: Tseng Min-Hua , Huang Shih-Ming , Lo Fu-Sung , Huang Jing-Long , Cheng Chih-Jen , Lee Hwei-Jen , Lin Shih-Hua
Published: November 2017

The functional study of different mutations on vitamin D receptor (VDR) gene causing hereditary vitamin D-resistant rickets (HVDRR) remains limited. This study was to determine the VDR mutation and the mechanisms of this mutation-causing phenotype in a family with HVDRR and alopecia. Phenotype was analyzed, and in vitro functional studies were performed. The proband and his affected sister exhibited typical HVDRR with alopecia, and their biochemical and radiographic abnormalities but not alopecia responded to supraphysiological doses of active vitamin D3. A novel homozygous missense R343H mutation in the exon 9 of VDR residing in the retinoid X receptor (RXR)-binding domain was identified. The expression level and C-terminal conformation of R343H mutant are not different from the wild-type VDR. This mutant had no effect on the nuclear localization of VDR, VDR-RXR heterodimerization, but it impaired CYP24A1 promoter activity in the presence of 1,25 (OH)2 vitamin D3, at least in part, mediated through specific nuclear receptor coactivator. Simulation models revealed the vanished interaction between guanidinium group of R343 and carboxyl group of E269. Without affecting the expression, conformation, nuclear location of VDR or heteridimerization with RXR, VDR-R343H impairs the transactivation activity of VDR on downstream transcription, accounting for HVDRR features with alopecia.
RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations
Authors: Fischer Marcus M. , Yeung V. Pete , Cattaruzza Fiore , Hussein Rajaa , Yen Wan-Ching , Murriel Christopher , Evans James W. , O’Young Gilbert , Brunner Alayne L. , Wang Min , Cain Jennifer , Cancilla Belinda , Kapoun Ann , Hoey Timothy
Published: November 2017

Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2 and RSPO3 gene fusions have been reported in CRC. We have previously shown that Wnt pathway blockers exhibit potent combinatorial activity with taxanes to inhibit tumor growth. Here we show that RSPO3 antagonism synergizes with paclitaxel based chemotherapies in patient-derived xenograft models (PDX) with RSPO3 fusions and in tumors with common CRC mutations such as APC, β-catenin, or RNF43. In these latter types of tumors that represent over 90% of CRC, RSPO3 is produced by stromal cells in the tumor microenvironment and the activating mutations appear to sensitize the tumors to Wnt-Rspo synergy. The combination of RSPO3 inhibition and taxane treatment provides an approach to effectively target oncogenic WNT signaling in a significant number of patients with colorectal and other intestinal cancers.
Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies
Authors: Benedikter Birke J. , Bouwman Freek G. , Vajen Tanja , Heinzmann Alexandra C. A. , Grauls Gert , Mariman Edwin C. , Wouters Emiel F. M. , Savelkoul Paul H. , Lopez-Iglesias Carmen , Koenen Rory R. , Rohde Gernot G. U. , Stassen Frank R. M.
Published: November 2017

Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted molecules for proteomic and functional studies. Conditioned media of BEAS-2B bronchial epithelial cells were concentrated on 10 kDa centrifuge filters, followed by separation of EVs and free protein using sepharose CL-4B SEC. Alternatively, EVs were isolated by ultracentrifugation. EV recovery was estimated by bead-coupled flow cytometry and tuneable resistive pulse sensing. The proteomic composition of EV isolates and SEC protein fractions was characterized by nano LC-MS/MS. UF-SEC EVs tended to have a higher yield and EV-to-protein rate of purity than ultracentrifugation EVs. UF-SEC EVs and ultracentrifugation EVs showed similar fold-enrichments for biological pathways that were distinct from those of UF-SEC protein. Treatment of BEAS-2B cells with UF-SEC protein, but not with either type of EV isolate increased the IL-8 concentration in the media whereas EVs, but not protein induced monocyte adhesion to endothelial cells. Thus, UF-SEC is a useful alternative for ultracentrifugation and allows comparing the proteomic composition and functional effects of EVs and free secreted molecules.
QED cascade with 10 PW-class lasers
Authors: Jirka Martin , Klimo Ondrej , Vranic Marija , Weber Stefan , Korn Georg
Published: November 2017

The intensities of the order of 1023–24 W/cm2 are required to efficiently generate electron-positron pairs in laser-matter interaction when multiple laser beam collision is employed. To achieve such intense laser fields with the upcoming generation of 10 PW laser beams, focusing to sub-micron spot size is required. In this paper, the possibility of pair production cascade development is studied for the case of a standing wave created by two tightly focused colliding laser pulses. Even though the stronger ponderomotive force expels the seed particles from the interaction volume when a tightly focused laser beam is used, tight focusing allows to achieve cascade pair production due to the higher intensity in the focal spot. Optimizing the target density can compensate the expulsion by the ponderomotive force and lower the threshold power required for cascade pair production. This will in principle allow to produce pairs with 10 PW-class laser facilities which are now under construction and will become accessible soon.
Development of a computationally-designed polymeric adsorbent specific for mycotoxin patulin
Authors: Piletska Elena V. , Pink Demi , Karim Kal , Piletsky Sergey A.
Published: November 2017

The developed bespoke polymer demonstrates a quantitative binding towards the patulin present in undiluted apple juice using conventional chromatography methods.
Functionalized gold nanoparticle-enhanced competitive assay for sensitive small-molecule metabolite detection using surface plasmon resonance
Authors: Cao Yong , Griffith Bethany , Bhomkar Prasanna , Wishart David S. , McDermott Mark T.
Published: November 2017

A functionalized gold nanoparticle-enhanced competitive assay was developed to overcome the sensitivity challenge associated with direct SPR sensing of small-molecule metabolites.
The adsorption behavior and mechanism of perfluorochemicals on oxidized fluorinated graphene sheets supported on silica
Authors: Li Fan , Wei Weili , Gao Die , Xia Zhining
Published: November 2017

A new mixed-mode adsorbent OFG@silica can selectively adsorb perfluorinated fatty acids (PFFAs) based on fluorophilicity, hydrophobicity and anion-exchange properties.
Colorimetric detection of hydrogen peroxide and glucose using brominated graphene
Authors: Singh Shikha , Mitra Kheyanath , Singh Rajshree , Kumari Archana , Sen Gupta Susanta Kumar , Misra Nira , Maiti Pralay , Ray Biswajit
Published: November 2017

Colorimetric detection of hydrogen peroxide and glucose using brominated graphene in the presence of 3,3′,5,5′-tetramethylbenzidine (TMB).
Self-assembled activated carbon nanoparticles for reliable time-discretized quantitative surface-enhanced Raman spectroscopy
Authors: Liu Yuping , Lu Zhiwei , Hasi Wuliji , Zhao Hang , Bao Lin , Yang Fang
Published: November 2017

Quantitative SERS is achieved by the saturated adsorption time of extraction film. Perturbations caused by performance change of substrates are overcome.
The development of a biomimetic enzyme-linked immunosorbent assay based on the molecular imprinting technique for the detection of enrofloxacin in animal-based food
Authors: Wang Jing , Sang Yaxin , Liu Weihua , Liang Na , Wang Xianghong
Published: November 2017

In this study, a direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method using molecularly imprinted polymers (MIPs) as artificial antibodies was developed to detect enrofloxacin (ENRO) in animal-based food.
Siloxane-based linkers in the construction of hydrogen bonded assemblies and porous 3D MOFs
Authors: Delmas Luke C. , Horton Peter N. , White Andrew J. P. , Coles Simon J. , Lickiss Paul D. , Davies Robert P.
Published: November 2017

A siloxane-based hexacarboxylic acid has been prepared and applied in the construction of new hybrid MOF materials.
Solution-processed single crystal microsheets of a novel dimeric phthalocyanine-involved triple-decker for high-performance ambipolar organic field effect transistors
Authors: Lu Guang , Kong Xia , Sun Junshan , Zhang Liangliang , Chen Yanli , Jiang Jianzhuang
Published: November 2017

Single-crystal microsheets of a novel dimeric phthalocyanine are successfully obtained via a facile solution process with excellent carrier mobilities of 18 cm2 V−1 s−1 for hole and 0.3 cm2 V−1 s−1 for electron, respectively.
Tunable plasmon resonance of molybdenum oxide nanoparticles synthesized in non-aqueous media
Authors: Lee Seung Hyuk , Nishi Hiroyasu , Tatsuma Tetsu
Published: November 2017

MoO2and MoO3−xnanoparticles that exhibit tunable plasmon resonance in the visible and near infrared ranges are synthesized in non-aqueous media.
A simple fluorene core-based non-fullerene acceptor for high performance organic solar cells
Authors: Suman Suman , Bagui Anirban , Datt Ram , Gupta Vinay , Singh Surya Prakash
Published: November 2017

A small molecule non-fullerene acceptor based on a fluorene core having a furan π-spacer and end capped with rhodanine (FRd2) is developed for solution processable bulk heterojunction organic solar cells (OSCs).
An exploration into the amide–pseudo amide hydrogen bonding synthon between a new coformer with two primary amide groups and theophylline
Authors: Markad Datta , Mandal Sanjay K.
Published: November 2017

Double the FUN! A rare amide–pseudo amide hydrogen bonding synthon has been established for the co-crystal between a new coformer with two primary amide groups and theophylline.
Control of chirality and catenation in cobalt and cadmium camphorate coordination complexes
Authors: Przybyla Jack J. , LaDuca Robert L.
Published: November 2017

Five cobalt or cadmium camphorate coordination polymers with various flexible-tether dipyridylamide ligands were structurally characterized. {[Co2(d-cam)2(pdn)]·2H2O}n (3, pdn = N,N′-(propane-1,3-diyl)dinicotinamide) has a self-penetrated 446810 mab network. {[Cd2(d-cam)2(pdn)]·H2O}n (4) shows a new 3,7-connected 3D network. The cadmium complexes were assayed for luminescent and nitrobenzene detection properties.
A novel 3D POMOF based on Wells–Dawson arsenomolybdates with excellent photocatalytic and lithium-ion battery performance
Authors: Cong Bo-Wen , Su Zhan-Hua , Zhao Zhi-Feng , Wang Bo
Published: November 2017

A novel 3D POMOF based on Wells–Dawson arsenomolybdates exhibits fluorescence property and efficient and stable photocatalytic activity for MB and RhB under UV irradiation and has also been evaluated as the anode material for LIBs.
One-pot scalable synthesis of all-inorganic perovskite nanocrystals with tunable morphology, composition and photoluminescence
Authors: Tsiwah Emmanuel Acheampong , Ding Yanxi , Li Zixiong , Zhao Zhiyong , Wang Mingqing , Hu Chao , Liu Xiaoqing , Sun Chenghua , Zhao Xiujian , Xie Yi
Published: November 2017

Tuning the morphology, composition and photoluminescence emission over almost the entire visible region of all-inorganic cesium lead halide nanocrystals by a general and facile one-pot synthetic approach.
Mechanism of enhancement of ferroelectricity of croconic acid with temperature
Authors: Mukhopadhyay Sanghamitra , Gutmann Matthias J. , Jiménez-Ruiz Mónica , Jochym Dominik B. , Wikfeldt Kjartan T. , Refson Keith , Fernandez-Alonso Felix
Published: November 2017

A microscopic study of the thermal behaviour of atomic motions in the organic ferroelectric croconic acid is presented in the temperature range 5–300 K.
Bonding and optical properties of spirocyclic-phosphazene derivatives. A DFT approach
Authors: Guajardo Maturana Raúl , Valenzuela María-Luisa , Schott Eduardo , Rojas-Poblete Macarena
Published: November 2017

The bonding properties of phosphazenes and spirocyclophosphazenes containing tris-2,2′-dioxybiphenyl groups and their derivatives were investigated by means of different computational techniques.
Tunable fluorescence behaviors of a supramolecular system based on a fluorene derivative and cucurbit[8]uril and its application for ATP sensing
Authors: Ye Rongqin , Cui Qianling , Yao Chuang , Liu Ronghua , Li Lidong
Published: November 2017

This host–guest complex shows tunable emission properties upon changing stoichiometry, and good ability in ATP sensing.
Surface Fe vacancy defects on haematite and their role in light-induced water splitting in artificial photosynthesis
Authors: Negreiros Fabio Ribeiro , Pedroza Luana Sucupira , Souza Flavio Leandro , Dalpian Gustavo Martini
Published: November 2017

A pathway for water dissociation near a surface Fe vacancy site on a hematite surface with photogenerated holes.
Photoelectron spectroscopy and density functional theory studies of (fructose + (H2O)n)− (n = 1–5) anionic clusters
Authors: Zeng Zhen , Bernstein Elliot R.
Published: November 2017

(Fructose + (H2O)n)− (n = 1–5) cluster anions mainly exist as open chain structures. Some cyclic structures of (fructose + (H2O)n)− (n = 3, 4) are present too.
Thionated naphthalene diimides: tuneable chromophores for applications in photoactive dyads
Authors: Pearce Nicholas , Davies E. Stephen , Horvath Raphael , Pfeiffer Constance R. , Sun Xue-Zhong , Lewis William , McMaster Jonathan , George Michael W. , Champness Neil R.
Published: November 2017

Thionation of naphthalene diimide and naphthalic imide phenothiazine dyads affords a systematic approach for tuning donor–acceptor energy gaps.
NEXAFS spectroscopy of ionic liquids: experiments versus calculations
Authors: Fogarty Richard M. , Matthews Richard P. , Clough Matthew T. , Ashworth Claire R. , Brandt-Talbot Agnieszka , Corbett Paul J. , Palgrave Robert G. , Bourne Richard A. , Chamberlain Thomas W. , Vander Hoogerstraete Tom , Thompson Paul B. J. , Hunt Patricia A. , Besley Nicholas A. , Lovelock Kevin R. J.
Published: November 2017

Experimental N 1s and S 1s NEXAFS spectra are compared to TD-DFT calculated spectra for 12 ionic liquids.
Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications
Authors: Zhu Chunlei , Xia Younan
Published: November 2017

This tutorial review introduces the concept of reconstituting low-density lipoprotein for the targeted delivery of different types of theranostic agents.
Specific recognition of Cr3+under physiological conditions by allyl substituted appendage rhodamine and its cell-imaging studies
Authors: Bhanja Anup Kumar , Mishra Snehasis , Naskar Kaushik , Maity Suvendu , Das Saha Krishna , Sinha Chittaranjan
Published: November 2017

An Allyl ether-Rhodamine probe emits yellow light (557 nm) in presence of Cr3+only with detection limit 33 nM from mixture of other cations and Cr(vi) in water-CH3CN medium at pH 7. Imaging of Cr3+species in living cells under physiological conditions is achieved.
Probing the excited state dynamics of Venus: origin of dual-emission in fluorescent proteins
Authors: Dhamija Shaina , Thakur Bhisham , Guptasarma Purnananda , De Arijit K.
Published: November 2017

We present studies on a yellow fluorescent protein variant, Venus, and investigate the photophysics behind the dual emission upon UV excitation in fluorescent proteins.
A biomimetic photoelectrocatalyst of Co–porphyrin combined with a g-C3N4 nanosheet based on π–π supramolecular interaction for high-efficiency CO2 reduction in water medium
Authors: Liu Jibo , Shi Huijie , Shen Qi , Guo Chenyan , Zhao Guohua
Published: November 2017

Aiming at high-efficiency biomimetic CO2 reduction, a photoelectrocatalyst with excellent CO2 catalytic activity was designed and prepared by self-assembly immobilizing CoTPP onto g-C3N4 based on π–π interaction.
Thermal responsiveness and binding affinity of cucurbit[7]uril terminal poly(N-isopropylacrylamide)
Authors: Hou Shengzhen , Chen Hao , Qiu Xiumin , Xu Wenchao , Tan Yebang
Published: November 2017

The introduction of CB[7] and guests raised the LCST of PNIPAM significantly, and CB[7]-PNIPAM maintained the high binding affinity of CB[7].
Coupled relaxation channels of excitons in monolayer MoSe2
Authors: Liu Bo , Meng Yuze , Ruan Xuezhong , Wang Fengqiu , Liu Wengqin , Song Fengqi , Wang Xuefeng , Wu Jing , He Liang , Zhang Rong , Xu Yongbing
Published: November 2017

Using ultrafast degenerate pump–probe spectroscopy, we report the exciton–exciton annihilation process is correlated with the defect trapping process.
High-efficiency near-infrared enabled planar perovskite solar cells by embedding upconversion nanocrystals
Authors: Meng Fan-Li , Wu Jiao-Jiao , Zhao Er-Fei , Zheng Yan-Zhen , Huang Mei-Lan , Dai Li-Ming , Tao Xia , Chen Jian-Feng
Published: November 2017

In situ embedding of upconversion nanocrystals in perovskite flm is developed and lead to a high PCE with enabled NIR response for planar solar cell.
Robust oil-core nanocapsules with hyaluronate-based shells as promising nanovehicles for lipophilic compounds
Authors: Szafraniec Joanna , Błażejczyk Agnieszka , Kus Edyta , Janik Małgorzata , Zając Gabriela , Wietrzyk Joanna , Chlopicki Stefan , Zapotoczny Szczepan
Published: November 2017

Biocompatible hyaluronate-based nanocapsules with liquid oil cores exhibiting long-term stability and tunable size were obtained in a versatile surfactant-free process and their biodistribution was studied in vivo and in vitro.
A self-assembly toolbox for thiophene-based conjugated polyelectrolytes: surfactants, solvent and copolymerisation
Authors: Houston Judith E. , Chevrier Michèle , Appavou Marie-Sousai , King Stephen M. , Clément Sébastien , Evans Rachel C.
Published: November 2017

Conjugated polythiophenes are transformed into a range of nanoscale morphologies using simple and versatile self-assembly strategies.
A new general approach to synthesizing filled and yolk–shell structured metal oxide microspheres by applying a carbonaceous template
Authors: Hong Young Jun , Roh Kwang Chul , Lee Jung-Kul , Kang Yun Chan
Published: November 2017

A general strategy for preparing filled and yolk–shell structured metal oxide microspheres applying carbonaceous template microspheres was introduced. A high loading rate of metal precursor in the carbonaceous template provided the breakthrough.
Brownian dynamics simulations of analytical ultracentrifugation experiments exhibiting hydrodynamic and thermodynamic non-ideality
Authors: Uttinger M. J. , Walter J. , Thajudeen T. , Wawra S. E. , Peukert W.
Published: November 2017

An extended Brownian Dynamics based algorithm incorporating hydrodynamic and thermodynamic non-ideality is presented.
Rocket-inspired tubular catalytic microjets with grating-structured walls as guiding empennages
Authors: Huang Gaoshan , Wang Jiyuan , Liu Zhaoqian , Zhou Dekai , Tian Ziao , Xu Borui , Li Longqiu , Mei Yongfeng
Published: November 2017

A rolled-up tubular microjet with a grating-structured wall which mimics the guiding empennage demonstrates an enhanced ability of moving linearly.
Fluorescent and colorimetric molecular recognition probe for hydrogen bond acceptors
Authors: Pike Sarah J. , Hunter Christopher A.
Published: November 2017

We report on the development of a dual molecular recognition probe for hydrogen bond acceptors.
Double thermoresponsive pentablock copolymers: synthesis by one-pot RAFT polymerization and self-assembly in aqueous solutions
Authors: Radzevicius Povilas , Steponaviciute Medeina , Krivorotova Tatjana , Makuska Ricardas
Published: November 2017

Pentablock copolymers synthesized by one-pot successive RAFT polymerization are double thermoresponsive and exhibit block sequence dependent aggregation in aqueous solutions.
Self-assembly of PEG/dodecyl-graft amphiphilic copolymers in water: consequences of the monomer sequence and chain flexibility on uniform micelles
Authors: Hattori Goki , Hirai Yuji , Sawamoto Mitsuo , Terashima Takaya
Published: November 2017

Self-assembly of hydrophilic poly(ethylene glycol) and hydrophobic dodecyl-graft amphiphilic copolymers in water was investigated in detail, by focusing on the effects of the monomer sequence and chain flexibility on micelles.
Morphology-controlled synthesis of TiO2/MoS2nanocomposites with enhanced visible-light photocatalytic activity
Authors: Sun Yuanqing , Lin Huihui , Wang Chuanxi , Wu Qian , Wang Xiaojie , Yang Minghui
Published: November 2017

Hollow and yolk–shell heterostructures of TiO2/MoS2nanocomposites are synthesizedviaa polymer assisted targeted-etching method and show high photocatalytic activity under sunlight.
Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C–Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis
Authors: Choy Pui Ying , Wong Shun Man , Kapdi Anant , Kwong Fuk Yee
Published: November 2017

This review article describes the palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C(Ar)–Z (Z = B, Si, Sn, S, N, C, H) bonds for facile bi(hetero)aryl synthesis in the past 10 years.
Formation of tetrasubstituted C–C double bondsviaolefin metathesis: challenges, catalysts, and applications in natural product synthesis
Authors: Mukherjee Nirmalya , Planer Sebastian , Grela Karol
Published: November 2017

Among the many types of transition-metal-catalysed C–C bond forming reactions, olefin metathesis is without a doubt one of the most thriving fields in modern organic synthetic chemistry.
Total synthesis of amphidinins E, F and epi-amphidinin F
Authors: Chen Kai , Xu Zhengshuang , Ye Tao
Published: November 2017

A unified approach leading to the total synthesis of amphidinins E, F and epi-amphidinin F of a new structural class of linear marine polyketides is described.
The influence of different N-substituted groups on the mechanochromic properties of 1,4-dihydropyridine derivatives with simple structures
Authors: Zhou Yibin , Qian Lebin , Liu Miaochang , Wu Ge , Gao Wenxia , Ding Jinchang , Huang Xiaobo , Wu Huayue
Published: November 2017

Four twisted 1,4-dihydropyridine derivatives with simple structure were synthesized. N-Substituted groups were found to play a decisive role in determining whether or not these compounds have mechanochromic activities.
Temperature- and frequency-dependent dielectric response and energy-storage performance in high (100)-oriented Sc doped (Na0.85K0.15)0.5Bi0.5TiO3 films
Authors: Wu Yunyi , Hu Yonghong , Wang Xiaohui , Zhong Caifu , Li Longtu
Published: November 2017

Highly (100)-oriented (Na0.85K0.15)0.5Bi0.5Ti0.75Sc0.25O3 (NKBT-Sc) films with thicknesses ranging from about 460 to 860 nm were grown by utilizing TiO2 layers engineering.
One-pot synthesis of ultrafine amphiphilic Janus gold nanoparticles by toluene/water emulsion reaction
Authors: Luo Kun , Hu Chengliang , Luo Yujia , Li Degui , Xiang Yongdong , Mu Yuanying , Wang Haiming , Luo Zhihong
Published: November 2017

Spontaneous phase separation of capping ligands at emulsion interfaces was used to synthesize amphiphilic Janus gold nanoparticles in batch.
Rieche formylation of carbon nanotubes – one-step and versatile functionalization route
Authors: Kolanowska Anna , Kuziel Anna , Li Yuliu , Jurczyk Sebastian , Boncel Sławomir
Published: November 2017

We present the direct and one-step Rieche formylation of carbon nanotubes (CNTs) as the most effective (4.00 mmol g−1) functionalization route via formylation.
Doping palladium with tellurium for the highly selective electrocatalytic reduction of aqueous CO2 to CO
Authors: Tao Hengcong , Sun Xiaofu , Back Seoin , Han Zishan , Zhu Qinggong , Robertson Alex W. , Ma Tao , Fan Qun , Han Buxing , Jung Yousung , Sun Zhenyu
Published: November 2017

The doping of Pd with a small amount of Te can selectively convert CO2 to CO with a low overpotential.
Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes
Authors: Cheung Chi Wai , Leendert Ploeger Marten , Hu Xile
Published: November 2017

A nickel-catalysed reductive aminocarbonylation of (hetero)aryl halides employing readily available nitro(hetero)arenes as the nitrogen source has been developed.
A highly efficient double-hierarchical sulfur host for advanced lithium–sulfur batteries
Authors: Hu Linyu , Dai Chunlong , Lim Jin-Myoung , Chen Yuming , Lian Xin , Wang Minqiang , Li Yi , Xiao Penghao , Henkelman Graeme , Xu Maowen
Published: November 2017

A double-hierarchical sulfur host has been synthesized in which hierarchical carbon spheres, constructed from building blocks of hollow carbon nanobubbles used for loading sulfur, are sealed by a polar MoS2 coating that is composed of ultrathin nanosheets (MoS2@HCS composite).
Selective electrochemical generation of benzylic radicals enabled by ferrocene-based electron-transfer mediators
Authors: Lennox Alastair J. J. , Nutting Jordan E. , Stahl Shannon S.
Published: November 2017

The use of ferrocene mediators offers significant advantages over direct electrolysis in the generation and functionalization of radicals from benzylboronates.
Gold-catalyzed stereoselective dearomatization/metal-free aerobic oxidation: access to 3-substituted indolines/oxindoles
Authors: Liu Kai , Xu Guangyang , Sun Jiangtao
Published: November 2017

An unprecedented gold-catalyzed dearomatization and a metal-free aerobic oxidation have been developed.
Facile synthesis of electrocatalytically active NbS2 nanoflakes for an enhanced hydrogen evolution reaction (HER)
Authors: Gopalakrishnan Deepesh , Lee Andrew , Thangavel Naresh Kumar , Reddy Arava Leela Mohana
Published: November 2017

We report a simple ambient pressure annealing technique for the synthesis of ultrathin niobium disulfide (NbS2) nanoflakes.
Arrested and temporarily arrested states in a protein–polymer mixture studied by USAXS and VSANS
Authors: Da Vela Stefano , Exner Christian , Schäufele Richard Santiago , Möller Johannes , Fu Zhendong , Zhang Fajun , Schreiber Frank
Published: November 2017

A three-stage coarsening kinetics is revealed by USAXS in a protein–polymer mixture approaching arrested liquid–liquid phase separation.
Diffusiophoresis in one-dimensional solute gradients
Authors: Ault Jesse T. , Warren Patrick B. , Shin Sangwoo , Stone Howard A.
Published: November 2017

We develop techniques for modeling the diffusiophoretic motions of charged colloidal particles that are exposed to one-dimensional solute gradients.
Membrane architecture with ion-conducting channels through swift heavy ion induced graft copolymerization
Authors: Sproll V. , Handl M. , Hiesgen R. , Friedrich K. A. , Schmidt T. J. , Gubler L.
Published: November 2017

Swift heavy ions create tracks of activated material in a polymer film for subsequent modification to form proton conducting channels.
Barium disilicide as a promising thin-film photovoltaic absorber: structural, electronic, and defect properties
Authors: Kumar Mukesh , Umezawa Naoto , Zhou Wei , Imai Motoharu
Published: November 2017

We report on a barium disilicide (BaSi2) system as a potential absorber material for thin-film solar cells within the density functional theory framework by using advanced methods like GW and BSE and elucidate the first report on the molecular orbital diagram and defect physics in BaSi2.
Chlorin e6 loaded lactoferrin nanoparticles for enhanced photodynamic therapy
Authors: Adimoolam Mahesh G. , A. Vijayalakshmi , Nalam Madhusudhana Rao , Sunkara Manorama V.
Published: November 2017

The LeN NPs of Lf and Ce6 enhanced the intracellular delivery of the PS improving photo-induced cell death compared to free PS.
Fabrication of sinter-free conductive Cu paste using sub-10 nm copper nanoparticles
Authors: Lee Jungsup , Jun Jaemoon , Na Wonjoo , Oh Jungkyun , Kim Yunki , Kim Wooyoung , Jang Jyongsik
Published: November 2017

Fabrication procedure of conductive Cu NP paste using sub-10 nm copper nanoparticles for excellent conductivity without heat treatment.
Correction: Solution-processable naphthalene and phenyl substituted carbazole core based hole transporting materials for efficient organic light-emitting diodes
Authors: Kumar Sudhir , An Chih-Chia , Sahoo Snehasis , Griniene Raimonda , Volyniuk Dmytro , Grazulevicius Juozas V. , Grigalevicius Saulius , Jou Jwo-Huei
Published: November 2017

Correction for ‘Solution-processable naphthalene and phenyl substituted carbazole core based hole transporting materials for efficient organic light-emitting diodes’ by Sudhir Kumar et al., J. Mater. Chem. C, 2017, 5, 9854–9864.
Complications of Cerebrospinal Fluid Diversion (Shunt) Catheters: A Pictorial Essay
Authors: Rahalkar M.
Published: November 2017

Ventriculoperitoneal shunt catheters are very commonly used for hydrocephalus of varying etiologies in infancy to childhood to bypass the obstruction. Few people are aware of their complications, such as infection, obstruction, malfunctioning, displacements, fluid collections, disconnections, and entry into various intra-abdominal organs. These complications and related literature and images are presented in this essay. In some cases, a radiologist can be of use to a neurosurgeon to alert what complication a given catheter has produced. The objectives are (1) to describe the types and functioning of cerebrospinal fluid diversion shunt catheters, (2) to know what can go wrong with the position and function of these catheters, and (3) to understand the specific or syndromic states of complication.
Broadening the Picture of Short-Chain Acyl-CoA Dehydrogenase Deficiency: A Case Report with Microcephaly, Leukoencephalopathy, and Characteristic Magnetic Resonance Spectroscopic Findings
Authors: Papadopoulou Maria , Koutsampasopoulou Iokasti , Tramma Despoina , Evangeliou Athanassios , Papadopoulou-Legbelou Kyriaki
Published: November 2017

Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a mitochondrial fatty acid metabolism disorder, which results in the accumulation of butyrylcarnitine and ethylmalonic acid in blood and urine. Evidence of genotype/phenotype correlation and neuroimaging characteristics is limited compared with other inborn errors of metabolism. We report a male patient with SCADD who initially presented with seizures, metabolic acidosis, microcephaly, and developmental delay with gradual amelioration of most symptoms. MRI/MRS revealed extended multifocal leukoencephalopathy, disturbed myelination, and abnormal brain energy metabolism with low choline/creatine ratio, which indicate the need for MRI/MRS follow-up even for asymptomatic patients with SCADD.
Der gefäßgestielte Omentumlappen zur Behandlung tiefer sternaler Wundinfekte
Authors: Spindler Nick , Etz Christian , Misfeld Martin , Josten Christoph , Borger Michael , Mohr Friedrich , Langer Stefan
Published: November 2017

Zielsetzung Defektdeckung einer persistierenden, sternalen Wundheilungsstörung, die nach frustranem Deckungsversuch mittels eines gestielten Latissimus-dorsi-Lappens durch eine Omentumplastik zur Ausheilung gebracht wurde.

Indikation Tiefe sternale Wundheilungsstörungen sind seltene, aber schwerwiegende Komplikationen nach medianer Sternotomie. Wenn reguläre Deckungsverfahren fehlschlagen oder nicht zu entfernendes Fremdmaterial wie „Drivelines“ oder Gefäßprothesen mittels Muskellappen nicht zur Ausheilung gebracht werden können, bildet der Omentumlappen, aufgrund seiner immunologischen Kompetenz, eine sinnvolle Alternative.

Methode Nach Exploration des persistierenden, sternalen Defekts schießt sich das radikale tangentiale Débridement und die Spülung der Wunde mittels einer Jet-Lavage an. Das Gewebe des Omentums wird nach Medianlaparotomie und Präparation des Lappens durch einen im vorderen Diaphragma angelegten Tunnel in den Defekt verlagert und kann hier spannungsfrei zur Ummantelung der Prothese verwendet werden. Der im Vorfeld verwendete Latissimuslappen wird in diesem Fall für den oberflächlichen Weichteilverschluss wiederverwendet.

Schlussfolgerung Insbesondere bei infiziertem, nicht entfernbarem Restmaterial stellt der Omentumlappen aufgrund seiner immunologischen Kompetenz eine gute Behandlungsalternative zu Muskellappen dar.
Klinische Anwendungen von wassergefiltertem Infrarot A (wIRA) – eine Übersicht
Authors: Hoffmann Gerd
Published: November 2017

Wassergefiltertes Infrarot A (wIRA) ist eine spezielle Form der Wärmestrahlung mit hohem Eindringvermögen in das Gewebe und geringer thermischer Belastung der Hautoberfläche.

wIRA steigert deutlich Temperatur, Sauerstoffpartialdruck und Durchblutung im Gewebe und wirkt auch über nicht-thermische zelluläre Effekte.

wIRA mindert indikationsübergreifend Schmerzen (mit relevant weniger Analgetikabedarf), Entzündung und vermehrte Sekretion und fördert Infektionsabwehr und Regeneration.

Entsprechend breit sind die klinischen Anwendungsmöglichkeiten von wIRA. wIRA ist ein kontaktfreies, verbrauchsmaterialfreies, leicht anzuwendendes, (selbst bei Wunden) als angenehm empfundenes Verfahren mit guter Tiefenwirkung und anhaltendem Wärmedepot.

wIRA ist u. a. einsetzbar zur Verbesserung der Heilung akuter und chronischer Wunden (wobei selbst eine ungestört “normal” ablaufende Wundheilung noch verbessert werden kann: schneller, schmerzärmer), bei Hauterkrankungen (wie vulgären Warzen, Herpes labialis, Herpes Zoster, Sklerodermie, Akne papulopustulosa; aktinischen Keratosen im Rahmen einer Photodynamischen Therapie), zur Resorptionsverbesserung topisch applizierter Substanzen, bei muskuloskeletalen Erkrankungen (wie Arthrosen, Arthritiden, Lumbago, ankylosierender Spondyloarthritis), zur Regeneration nach Sport, beim komplexen regionalen Schmerzsyndrom (CRPS), bei Polyneuropathien und in Kombination mit Strahlentherapie oder Chemotherapie in der Onkologie.
Skill-Grade-Mix ist ein Kulturwandel
Authors: Fröhlich Martin R. , Massarotto Paola , Brenner-Lüdemann Gabi , Staudacher Diana
Published: November 2017

Kompetenzgerechter Personaleinsatz auf Intensivstationen Im Tandem
arbeiten, einander ergänzen und Mitarbeitende mit unterschiedlichsten
Berufsabschlüssen ins Team integrieren – dies gehört zu den vielfältigen Chancen
und Herausforderungen des Skill-Grade-Mix. Als zukunftsorientiertes Modell der
Zusammenarbeit hat sich der Skill-Grade-Mix auf den Intensivstationen des
Universitätsspitals Zürich bewährt. Er ist eine Antwort auf Personalengpässe,
wirkt nachwuchsfördernd und leitet einen Kulturwandel ein: Unterschiedliche
pflegerische Berufsgruppen übernehmen gemeinsam Verantwortung für Patienten.
Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation
Authors: Crascì Lucia , Cardile Venera , Longhitano Giusy , Nanfitò Francesco , Panico Annamaria
Published: November 2017

Background Inflammation is a dynamic process that occur on vascularized tissue in response to different stimuli causing cell injury and tissue degeneration. Reactive oxygen and nitrogen species (ROS and RNS) and advanced glycation end products (AGEs) have a key mediatory role in the development and progression of degenerative tissue process. The bioflavonoids possess a broad-spectrum of pharmacological activities. Their capability is related to their chemical structure.

Methods In this study we evaluated and compare antioxidant, anti-glycative and anti-degenerative actions of two flavones apigenin and luteolin and a flavonol quercetin, in function of their hydroxyl groups arrangement. Moreover we assay, on NCTC 2544 and chondrocytes cultures, the flavonoids capacity to modulate NO and glycosamminoglycans levels, index of antidegenerative capacity.

Results All tested flavonoids act as free radicals scavengers (ROO• and NO•) and advanced glycation end products inhibitors, in agreement with their BDE, IP and molecular planarity. Quercetin showed a high ORAC value (2.70±0.12 ORAC Units), according to a low BDE (74.54 Kcal/mol) and IP (174.44 Kcal/mol) values. Luteolin is the most active compound in the NO (48.19±0.18%) and AGEs (60.06±0.52%) inhibition, in function of a low torsion angle (16.3°) between the 3-OH moiety and C’6 carbon atom.

Conclusion All tested flavonoids posses a protective role on degenerative tissue events. They acts in different manner depending on the functional groups, the biological substrate and the concentration used. In any case, it can be considered a suitable product preventing a degenerative processes.
Non-constant link tension coefficient in the tumbling-snake model subjected to simple shear
Authors: Stephanou Pavlos S. , Kröger Martin
Published: November 2017

The authors of the present study have recently presented evidence that the tumbling-snake model for polymeric systems has the necessary capacity to predict the appearance of pronounced undershoots in the time-dependent shear viscosity as well as an absence of equally pronounced undershoots in the transient two normal stress coefficients. The undershoots were found to appear due to the tumbling behavior of the director u when a rotational Brownian diffusion term is considered within the equation of motion of polymer segments, and a theoretical basis concerning the use of a link tension coefficient given through the nematic order parameter had been provided. The current work elaborates on the quantitative predictions of the tumbling-snake model to demonstrate its capacity to predict undershoots in the time-dependent shear viscosity. These predictions are shown to compare favorably with experimental rheological data for both polymer melts and solutions, help us to clarify the microscopic origin of the observed phenomena, and demonstrate in detail why a constant link tension coefficient has to be abandoned.
Thin grain oriented electrical steel for PWM voltages fed magnetic cores
Authors: Belgrand Thierry , Lemaître Régis , Benabou Abdelkader , Blaszkowski Jonathan , Wang Chaoyong
Published: November 2017

This paper reports on performances of high permeability grain oriented electrical steel when used in association with power electronic switching devices. Loss measurement results obtained from the Epstein test, using sinusoidal or various PWM voltages in medium frequency range, show that for both studied thicknesses (HGO 0.23mm and HGO 0.18mm), comparing performances at a fixed induction level between the various situations may not be the most convenient method. The effect of magnetic domain refinement has been investigated. After having shown the interest of lowering the thickness, an alternative way of looking at losses is proposed that may help to design the magnetic core when it comes to the matter of reducing size in considering frequency and magnetization levels.