bluuebunny/crossref_metadata_2025 huggingface dataset:
Soil texture and environmental conditions influence the biogeochemical responses of soils to drought and flooding
Authors: Patel Kaizad F. , Fansler Sarah J. , Campbell Tayte P. , Bond-Lamberty Ben , Smith A. Peyton , RoyChowdhury Taniya , McCue Lee Ann , Varga Tamas , Bailey Vanessa L.
Published: June 2021

Climate change is intensifying the global water cycle, with increased frequency of drought and flood. Water is an important driver of soil carbon dynamics, and it is crucial to understand how moisture disturbances will affect carbon availability and fluxes in soils. Here we investigate the role of water in substrate-microbe connectivity and soil carbon cycling under extreme moisture conditions. We collected soils from Alaska, Florida, and Washington USA, and incubated them under Drought and Flood conditions. Drought had a stronger effect on soil respiration, pore-water carbon, and microbial community composition than flooding. Soil response was not consistent across sites, and was influenced by site-level pedological and environmental factors. Soil texture and porosity can influence microbial access to substrates through the pore network, driving the chemical response. Further, the microbial communities are adapted to the historic stress conditions at their sites and therefore show site-specific responses to drought and flood.
Imaging therapeutic peptide transport across intestinal barriers
Authors: Larsen Jannik Bruun , Taebnia Nayere , Dolatshahi-Pirouz Alireza , Eriksen Anne Zebitz , Hjørringgaard Claudia , Kristensen Kasper , Larsen Nanna Wichmann , Larsen Niels Bent , Marie Rodolphe , Mündler Ann-Kathrin , Parhamifar Ladan , Urquhart Andrew James , Weller Arjen , Mortensen Kim I. , Flyvbjerg Henrik , Andresen Thomas Lars
Published: June 2021

Understanding how pharmaceutical peptides transport across the intestinal barrier could increase their bio-availability. To this end, fluorescence imaging offers a unique combination of spatiotemporal resolution and compatibility with living systems.
Facile synthesis of tribenzosilepins from terphenyls and dihydrosilanes by electrophilic double silylation
Authors: Dong Yafang , Sekine Kohei , Kuninobu Yoichiro
Published: June 2021

Tribenzosilepins were synthesized from terphenyls and dihydrosilanes via a facile approach using a double sila-Friedel–Crafts reaction.
Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic
Authors: Altenhofer Erich F. , Lawler Michael J. , Kumar Pankaj , Joyce Leo A. , Fowler-Watters Matthew , Pei Tao , Li Zhen
Published: June 2021

A novel cyclopropanation has been demonstrated by tuning the electronics of the substrate, allowing for conversion of the highly stable 1,4-adduct to the desired cyclopropane.
Efficient depolymerization of lignins to alkylphenols using phosphided NiMo catalysts
Authors: Osorio Velasco Jessi , van der Linden Ilse , Deuss Peter J. , Heeres Hero J.
Published: June 2021

A series of phosphided NiMo catalysts on different supports was tested for the catalytic hydrotreatment of lignins to biobased building blocks like alkylphenols.
An efficient Ni–P amorphous alloy electrocatalyst with a hierarchical structure toward borohydride oxidation
Authors: Yu Jingjing , Hu Bihao , Xu Chuanlan , Meng Jiazhi , Yang Shu , Li Yan , Zhou Xiaoyuan , Liu Yuping , Yu Danmei , Chen Changguo
Published: June 2021

A Ni–P@NF amorphous alloy catalyst electrode with a unique hierarchical structure shows excellent catalytic activity, stability and durability toward borohydride oxidation.
Co(OH)2water oxidation cocatalyst-decorated CdS nanowires for enhanced photocatalytic CO2reduction performance
Authors: Xu Yuyan , Xie Zhongkai , Yu Rui , Chen Min , Jiang Deli
Published: June 2021

A Co(OH)2nanoparticle decorated CdS nanowire (Co(OH)2/CdS) based heterostructured photocatalyst was prepared. The optimal Co(OH)2/CdS photocatalyst achieves a CO production rate of 8.11 μmol g−1h−1under visible light irradiation (λ> 420 nm).
High-sensitivity and wide-temperature-range dual-mode optical thermometry under dual-wavelength excitation in a novel double perovskite tellurate oxide
Authors: Wu Zhaojie , Li Li , Tian Guang , Wang Yongjie , Ling Faling , Cao Zhongmin , Jiang Sha , Xiang Guotao , Li Yanhong , Zhou Xianju
Published: June 2021

The high-sensitivity and wide-temperature-range dual-mode optical thermometry for novel double perovskite SrLaLiTeO6:Mn4+,Dy3+ phosphor was exploited. Notably, the relative sensitivity (SR) values can be manipulated by different excitation wavelength.
Local inhomogeneities resolved by scanning probe techniques and their impact on local 2DEG formation in oxide heterostructures
Authors: Rose M.-A. , Barnett J. , Wendland D. , Hensling F. V. E. , Boergers J. M. , Moors M. , Dittmann R. , Taubner T. , Gunkel F.
Published: June 2021

Using c-AFM and s-SNOM, we show the influence of local inhomogeneities on the LAO/STO 2DEG formation by mapping its distribution. The nanoscopic arrangement of insulating regions alters the conductive behavior down to low temperatures.
Plasmonic metal nanostructures with extremely small features: new effects, fabrication and applications
Authors: Shi Huimin , Zhu Xupeng , Zhang Shi , Wen Guilin , Zheng Mengjie , Duan Huigao
Published: June 2021

The schematic illustration of the new effects, advanced fabrication and crucial applications of plasmonic metal nanostructures with extremely small features.
Improved electrocatalytic activity of Pt catalyst supported on core–shell CMs@NiO for methanol oxidation
Authors: Luo Yongping , Zhong Wei , Huang Ping , Ou Hui , Fu Haiyan , Liu Chen , Xiao Zonghu , Xu Shunjian
Published: June 2021

The as-prepared Pt catalyst supported on core–shell CMs@NiO for the methanol oxidation with the extraordinary electrocatalytic performance and durability.
Cycloaddition of carbon dioxide and epoxides catalyzed by rare earth metal complexes bearing a Trost ligand
Authors: Cheng Jun , Lu Chengrong , Zhao Bei
Published: June 2021

Rare earth metal complexes containing Trost ligands were used to catalyze the cycloaddition reaction of epoxides with CO2. A series of epoxides were successfully converted into the corresponding cyclic carbonates under mild conditions.
Flexible, superhydrophobic and multifunctional carbon nanofiber hybrid membranes for high performance light driven actuators
Authors: Song Xin , Huang Xuewu , Luo Junchen , Long Biao , Zhang Weimiao , Wang Ling , Gao Jiefeng , Xue Huaiguo
Published: June 2021

A flexible CNF hybrid membrane was synthesized via electrospinning, then two step annealing, and finally dip coating. The superhydrophobic CNF membrane with excellent photo-thermal conversion is beneficial for controllable motion on the water.
Ionic conductivity and dielectric properties of bulk SPP-PEG hydrogels as Na+ion-based SPE materials for energy storage applications
Authors: Tiwari Rudramani , Verma Dipendra Kumar , Kumar Devendra , Yadav Shashikant , Kumar Krishna , Krishnamoorthi S.
Published: June 2021

A non-flammable, non-hazardous, eco-friendly polymeric hydrogel material with a floating sandwiched layer was prepared by a green chemistry method for energy storage applications.
A novel 3D porous electrode of polyaniline and PEDOT:PSS coated SiNWs for low-cost and high-performance supercapacitors
Authors: Shen Xiaojuan , Zhang Xuan , Wang Tongfei , Li Songjun , Li Zhaoqiang
Published: June 2021

A novel 3D porous polymer-coated SiNW supercapacitor electrode is developed using a simple and low temperature method. With the optimized charge transfer path, the electrode is first fabricated on a solar-grade Si wafer.
An ultrasensitive colorimetric and fluorescence dual-readout assay for glutathione with a carbon dot–MnO2 nanosheet platform based on the inner filter effect
Authors: He Mengyuan , Shang Ning , Zheng Bo , Yue Gege
Published: June 2021

An ultrasensitive colorimetric and fluorescence dual-readout assay based on carbon dot–MnO2 nanosheets platform was developed for GSH detection in human body fluid samples.
Controlled assembly of cobalt embedded N-doped graphene nanosheets (Co@NGr) by pyrolysis of a mixed ligand Co(ii) MOF as a sacrificial template for high-performance electrocatalysts
Authors: Bhadu Gopala Ram , Parmar Bhavesh , Patel Parth , Chaudhari Jayesh C. , Suresh Eringathodi
Published: June 2021

Synthesis, characterization and application of monodispersed cobalt embedded nitrogen-doped graphene derived from a cobalt-based mixed ligand MOF by pyrolysis as a bifunctional electrocatalyst for water splitting have been investigated.
Selective removal of toxic organic dyes using Trӧger base-containing sulfone copolymers made from a metal-free thiol-yne click reaction followed by oxidation
Authors: Baig Noorullah , Shetty Suchetha , Moustafa Moustafa Sherief , Al-Mousawi Saleh , Alameddine Bassam
Published: June 2021

Copolymers TCP1–3 with Trӧger's base units and aryl thioether groups were made via a click reaction. Selective oxidation of the thioethers into sulfone groups afforded TCP4–6 which display up to 100% removal efficiency of methylene blue from water.
Influence of metal oxide and heteropoly tungstate location in mesoporous silica towards catalytic transfer hydrogenation of furfural to γ-valerolactone
Authors: Srinivasa Rao B. , Yogita  , Dhana Lakshmi D. , Kumari P. Krishna , Lingaiah N.
Published: June 2021

One pot conversion of furfural to γ-valerolactone by transfer hydrogenation has been achieved over bifunctional mesoporous silica catalysts containing Zr and tungstophosphoric acid (TPA).
In situ electron holography for characterizing Li ion accumulation in the interface between electrode and solid-state-electrolyte
Authors: Yang Y. , Cui J. , Guo H. J. , Shen X. , Yao Y. , Yu R. C. , Wen R.
Published: June 2021

The reconstructed phase image of the in situ holography unravels Li ion behavior in the electrolyte beneath the electrode during the charging process.
Simultaneous hydrogen and oxygen evolution reactions using free-standing nitrogen-doped-carbon–Co/CoOx nanofiber electrodes decorated with palladium nanoparticles
Authors: Barhoum Ahmed , El-Maghrabi Heba H. , Nada Amr A. , Sayegh Syreina , Roualdes Stéphanie , Renard Aurélien , Iatsunskyi Igor , Coy Emerson , Bechelany Mikhael
Published: June 2021

Free-standing N-CNF–Co/CoOx electrodes were fabricated by electrospinning followed by thermal pyrolysis. Controlled atomic layer deposition of Pd NPs on these nanofibers significantly increased electrode electrochemical activity in water splitting.
Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment
Authors: Brunetta Henver S. , Petrick Heather L. , Vachon Bayley , Nunes Everson A. , Holloway Graham P.
Published: June 2021

Reductions in mitochondrial function have been proposed to cause insulin resistance, however the possibility that impairments in insulin signaling negatively affects mitochondrial bioenergetics has received little attention. Therefore, we tested the hypothesis that insulin could rapidly improve mitochondrial ADP sensitivity, a key process linked to oxidative phosphorylation and redox balance, and if this phenomenon would be lost following high-fat diet (HFD)-induced insulin resistance. Insulin acutely (60 min post I.P.) increased submaximal (100–1000 µM ADP) mitochondrial respiration ∼2-fold without altering maximal (>1000 µM ADP) respiration, suggesting insulin rapidly improves mitochondrial bioenergetics. The consumption of HFD impaired submaximal ADP-supported respiration ∼50%, however, despite the induction of insulin resistance, the ability of acute insulin to stimulate ADP sensitivity and increase submaximal respiration persisted. While these data suggest that insulin mitigates HFD-induced impairments in mitochondrial bioenergetics, the presence of a high intracellular lipid environment reflective of an HFD (i.e. presence of palmitoyl-CoA) completely prevented the beneficial effects of insulin. Altogether, these data show that while insulin rapidly stimulates mitochondrial bioenergetics through an improvement in ADP sensitivity, this phenomenon is possibly lost following HFD due to the presence of intracellular lipids.
A major asymmetric ice trap in a planet-forming disk
Authors: van der Marel Nienke , Booth Alice S. , Leemker Margot , van Dishoeck Ewine F. , Ohashi Satoshi
Published: June 2021

Context. The chemistry of planet-forming disks sets the exoplanet atmosphere composition and the prebiotic molecular content. Dust traps are of particular importance as pebble growth and transport are crucial for setting the chemistry where giant planets form.

Aims. The asymmetric Oph IRS 48 dust trap located at 60 au radius provides a unique laboratory for studying chemistry in pebble-concentrated environments in warm Herbig disks with gas-to-dust ratios as low as 0.01.

Methods. We use deep ALMA Band 7 line observations to search the IRS 48 disk for H2CO and CH3OH line emission, the first steps of complex organic chemistry.

Results. We report the detection of seven H2CO and six CH3OH lines with energy levels between 17 and 260 K. The line emission shows a crescent morphology, similar to the dust continuum, suggesting that the icy pebbles play an important role in the delivery of these molecules. Rotational diagrams and line ratios indicate that both molecules originate from warm molecular regions in the disk with temperatures > 100 K and column densities ∼1014 cm−2 or a fractional abundance of ∼10−8 and with H2CO/CH3OH ∼0.2, indicative of ice chemistry. Based on arguments from a physical-chemical model with low gas-to-dust ratios, we propose a scenario where the dust trap provides a huge icy grain reservoir in the disk midplane, or an ‘ice trap’, which can result in high gas-phase abundances of warm complex organic molecules through efficient vertical mixing.

Conclusions. This is the first time that complex organic molecules have been clearly linked to the presence of a dust trap. These results demonstrate the importance of including dust evolution and vertical transport in chemical disk models as icy dust concentrations provide important reservoirs for complex organic chemistry in disks.
LoTSS jellyfish galaxies
Authors: Roberts I. D. , van Weeren R. J. , McGee S. L. , Botteon A. , Ignesti A. , Rottgering H. J. A.
Published: June 2021

Ram pressure stripping is a frequently cited mechanism for quenching galaxy star formation in dense environments. Numerous examples of ram pressure stripping in galaxy clusters are present in literature; however, substantially less work has been focused on ram pressure stripping in lower-mass groups, the most common galaxy environment in the local Universe. In this work we use the LOFAR Two-metre Sky Survey (LoTSS) to search for jellyfish galaxies (i.e., galaxies with ram pressure stripped tails extending beyond the optical disk) in ∼500 SDSS groups (z < 0.05), making this the most comprehensive search for ram pressure stripping in groups to date. We identify 60 jellyfish galaxies in groups with extended, asymmetric radio continuum tails, which are found across the entire range of group mass from 1012.5 < Mgroup < 1014 h−1 M⊙. We compare the group jellyfish galaxies identified in this work with the LoTSS jellyfish galaxies in clusters presented in a recent work, allowing us to compare the effects of ram pressure stripping across three decades in group and cluster mass. We find that jellyfish galaxies are most commonly found in clusters, with the frequency decreasing towards the lowest-mass groups. Both the orientation of observed radio continuum tails and the positions of group jellyfish galaxies in phase space suggest that galaxies are stripped more slowly in groups relative to clusters. Finally, we find that the star formation rates of jellyfish galaxies in groups are consistent with ‘normal’ star-forming group galaxies, which is in contrast to cluster jellyfish galaxies that have clearly enhanced star formation rates. On the whole, there is clear evidence for ongoing ram pressure stripping in galaxy groups (down to very low group masses), though the frequency of jellyfish galaxies and the strength of ram pressure stripping appear lower in groups than in clusters. Differences in the efficiency of ram pressure stripping in groups versus clusters likely contribute to the positive trend between the quenched fraction and host halo mass observed in the local Universe.
Open-loop and closed-loop solvabilities for stochastic linear quadratic optimal control problems of Markovian regime switching system
Authors: Zhang Xin , Li Xun , Xiong Jie
Published: June 2021

This paper investigates the stochastic linear quadratic (LQ, for short) optimal control problem of Markovian regime switching system. The representation of the cost functional for the stochastic LQ optimal control problem of Markovian regime switching system is derived by the technique of Itô’s formula with jumps. For the stochastic LQ optimal control problem of Markovian regime switching system, we establish the equivalence between the open-loop (closed-loop, resp.) solvability and the existence of an adapted solution to the corresponding forward-backward stochastic differential equation with constraint. (i.e., the existence of a regular solution to Riccati equations). Also, we analyze the interrelationship between the strongly regular solvability of Riccati equations and the uniform convexity of the cost functional. Finally, we present an example which is open-loop solvable but not closed-loop solvable.
The Impact of New Energy Development on Energy Intensity and Economic Growth
Authors: Sun Jing
Published: June 2021

In recent years, new energy has been rapidly developed and applied. The development of new energy has promoted China's economic growth to a specific extent. The use of new energy has brought energy security to the development of the national economy. Based on the development trend of new energy at home and abroad, this paper analyses the impact of energy intensity and economic growth on the development of new energy. This article explores the relationship between China's new energy, energy intensity and economic development through comparative analysis at home and abroad. This article has a certain reference value for the adjustment of the national new energy industrial structure. This article also has a certain reference value for the construction of new energy development strategies and the control of carbon emissions.
Research on Bi-level Cooperative Robust Planning of Distributed Renewable Energy in Incremental Distribution Network Considering Demand Response
Authors: Yi Sui , Jianbin Wu , Huiqing Liu , Chunhui Li , Shuai Zhao , Jin Gao , Yang Bai
Published: June 2021

The paper constructs a two-level collaborative planning model for incremental distribution network considering demand response and distributed renewable energy access. In the upper model, the goal is to minimize the investment cost of the distribution network, and the lower model takes the system's operating cost optimally, fully considers the uncertainty of renewable energy output, and introduces robust optimization to solve it. It can be seen from the simulation results that the consideration of demand response in the distribution network planning is conducive to delaying investment costs, enhancing power user load flexibility, and effectively avoiding load shedding and other problems. The research results lay the foundation for the feasibility of demand response resources participating in power grid planning
Research on improving development effect of high-saturated reservoir in the late stage of water-flooding
Authors: Shi Xiaoying , Guan Huajiao , Zhao Hui , Jiang Yali , Li Yuying , Xue Zhao
Published: June 2021

High-saturated reservoir is characterized by high saturation pressure and high gas-oil ratio. The effects of water flooding are easily influenced by the formation pressure and GOR, especially at the late stage. This article presents the relationship between the reasonable pressure maintenance level and GOR as well as water cut based on the actual characteristics of high-saturated reservoir. Then, the reservoir numerical simulation method is used to analyse the influence of pressure recovery rate and water cut rise under different injection-production ratios and injection-production methods. Research results show that the pressure maintenance level of high-saturated reservoir is larger than normal reservoirs. Bigger injection-production ratio results in not only faster pressure recovery rate but also higher water cut. Cyclic injection and production method under the maximum injection rate and liquid extraction amount can enhance oil recovery rate and control water cut rise at the same time, which plays a significant role in improving the development effect of water-flooding in high-saturated reservoirs at the late stage.
Research on operation scenario based aircraft power system architecture analysis and modelling
Authors: Dongsheng Chen , Yan He , Mengqian Zhou
Published: June 2021

Aircraft power system is a complex system consisting of the power generation system, the power management and distribution system, and the power consumption system, which accounts for the aircraft's major fuel consumption and emissions. This paper proposes a scenario-based comprehensive power requirement analysis and system architecture methodology in order to alleviate the risk of systems over-design and discoordination caused by traditional bottom-up load collection and individual system design. Starting from the operation scenario, system functions are identified and corresponding physical architecture and power loads are analysed. Given the complexity of operation scenarios and aircraft power system, model-based system engineering methodology is applied to the top-down aircraft power system architecture design. SysML tool is used to carry out to analyse the aircraft power system architecture during taxi scenario, which provides great advantages on model tracing and reuse.
Economic analysis of wind power consumption promoted by regenerative electric heating with high proportion of renewable energy
Authors: Zhenyu Wang , Jianhua Zhang , Chong Shao , Lanlan Xu , Yongjun Han
Published: June 2021

With the rapid development of wind power, the randomness and volatility of wind power have also caused severe problems of wind power consumption. The phenomenon of wind abandonment is particularly prominent in the "three north" areas. The environmental protection and controllability of regenerative electric heating provide a way for wind absorption and abandonment. Therefore, this paper proposes a model to promote wind power consumption by using regenerative electric heating. Firstly, the principle and advantages of the heat storage electric heating equipment are described; secondly, the fine modeling of regenerative electric heating is carried out;then, the mode of using regenerative electric heating to promote wind power consumption is designed;finally, an example is given to analyze the wind power consumption effect and the revenue of load aggregators.Therefore, it is verified that this mode can effectively promote wind power consumption and reduce wind abandon generation, and provide reference for alleviating wind abandon and power limit problem.
Location planning of electric taxi charging station based on driving trajectory
Authors: Hehuan  , GeQin
Published: June 2021

With the vigorous development of energy technology, the promotion and use of electric vehicles has brought new vitality to the development of ecological environment. According to the big data of taxi travel trajectory, we can get the idle rule of taxi operation time. Taking the idle time and location of taxi as the demand hot spot, taking the location points along the road network of the research area as the candidate points, this paper uses ArcGIS to do the location planning of charging station, so that the charging station can reduce the charging anxiety of taxi drivers, meet the charging demand to the maximum extent, and get the the minimum number of stations, and the quantity and distribution are taken as the site selection scheme..
Simulation of single cell electroporation
Authors: Liu Qingmeng , Yang Lei
Published: June 2021

This paper attempts to introduce the dynamics of electroporation into the single cell model. The main characteristics of the model were described. Results show the generation and rise of pores in a round cell with a radius of 50 μm exposed to 40 kV/m electric field for 1 ms were analysed, so that the transmembrane potential, the number of pores and the membrane conductance could be calculated. Finally, how the model can help explain the experiment is discussed.
High quality development evaluation of western counties based on resources and environment synergy: a case study of Datong County, Qinghai Province
Authors: Li Jia , Ding Shengxi
Published: June 2021

Resources and environment is the carrier and material basis of regional sustainable development. Regional high-quality development must adhere to the protection of resources and environment. Based on the investigation and empirical analysis of the current situation of industrial development in Datong County of Qinghai Province, this paper puts forward some countermeasures and suggestions to promote the coordinated high-quality development of resources, environment and industry in Datong County.
Research on the Influencing Factors of Air-puff Test after SMILE Based on Finite Element Analysis
Authors: Lin Luchao , Fang Lihua , Tao Xingming , Song Yinyu , Du Ruirui
Published: June 2021

The three-dimensional finite element model of the postoperative whole human eye after small incision lenticule extraction (SMILE) surgery and the axisymmetric air-puff model were established, the influencing factors in the Air-puff test were explored from the displacement nephogram on anterior corneal surface. Our results showed that the maximum depression displacement was positively correlated with the corrected diopter when the peak pressure of ejection and air-puff center location were constant, but the highest concavity radius of concave curvature was negatively correlated with the corrected diopter. At the same time, we also found that when the decentration of air-puff center position was 1mm, the maximum depression displacement of the anterior corneal surface was reduced by 8.3% under the condition of constant correction diopter and peak air-puff pressure, compared with the maximum depression displacement of the anterior corneal surface when the decentration of air-puff center position was 0 mm. In conclusion, the corrected diopter and decentration of air-puff position have an important effect on the results of air-puff test after SMILE.
Analysis on Factors of Forgetting and Three Ways for Effective Memory
Authors: Zeng XinYi
Published: June 2021

Psychologists often attribute the term 'memory' to the retention of information like knowledge or experience. This paper focuses on the reason why not only older people but also the younger generation have been reported that they often forget about certain things that happened before or not happened yet. This paper includes the methods of comparing several data from different studies and citing many conclusions in other studies. This paper presents current knowledge about how and why people usually forget. The conclusion I draw from this whole process of writing is that the factors such as the aging, stress and emotion, encoding failure, storage failure, and the retrieval failure can influence differently on the retain of the memory. But, still, we have some solutions to do our utmost in reducing their effects.
The Effect of GABAA Receptor on Information Capacity of Cultured Hippocampal Neurons
Authors: Zhu Geng , Li Xiangning , Gong Hui , Zhu Yan , Li Xiaoou
Published: June 2021

Neural information is encoded by action potentials delivered by neurons. Which component of neural activity constitutes the basic unit carrying information is still a controversial issue. In this paper, stimulation experiments using a network of hippocampal neurons cultured on a multi-electrode array are used to investigate this issue. The results show that for a set of pulse stimuli with varying voltage amplitude, the neuronal response to the fronto-potential sequence encodes more information through the moment of fronto-potential delivery than the number of fronto-potential deliveries, and that neurons at each locus are encoded independently of each other. After the addition of bicuculline inhibited the GABAA receptors, the information capacity decreased and the temporal resolution decreased, but the neurons at each site were still encoded independently. The results suggest that the encoding of stimulus amplitude in the cultured hippocampal neuronal network is better with spike timing than with count, and the effect of timing encoding is dependent on GABAA receptors.
Excitation Contraction Coupling in Hypertrophy and Failing Heart Cells
Authors: Zhou Yiqiu
Published: June 2021

The contraction of the heart is dependent on a process named the excitation-contraction coupling (E-C coupling). In hypertrophy and failing heart models, the expression, phosphorylation and function of key calcium handling proteins involved in E-C coupling are altered. It’s important to figure out the relationship changes between calcium channel activity and calcium release from sarcoplasmic reticulum (SR). This review will therefore focus on novel components of E-C coupling dysfunction in hypertrophy and failing heart, such as L-type Ca2+ channel (LCC), ryanodine receptor type-2 channel (RyR2) and SR Ca ATPase (SERCA), and how these molecular modifications altered excitation-contraction coupling. A lot of literature was well read and sorted. Recent findings in E-C coupling during hypertrophy and heart failure were focused on. Most importantly, the electrophysiological and signal pathway data was carefully analyzed. This review summarizes key principles and highlights novel aspects of E-C coupling changes during hypertrophy and heart failure models. Although LCC activity changed little, the loss of notch in action potential, reduced Ca2+ transient amplitude and desynchronized Ca2+ sparks resulted in a decreased contraction strength in hypertrophy and heart failure models. What’s more, L-type Ca2+ current becomes ineffective in triggering RyR2 Ca2+ release from SR and the SR uptake is reduced in some models. It has great meanings in understanding the E-C coupling changes during different heart diseases. Theses novel changes suggest potential therapeutic approaches for certain types of hypertrophy and heart failure.
Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology
Authors: Yue Yitong , Xue Shengping , Yue Zhanjun , Fang Weijin , Li Kang , Gao Jiaqi
Published: June 2021

Acne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents were collected and sorted out in the past twenty years. Excel 2019 was used for medication frequency statistics, and IBM SPSS 25.0 was used for clustering analysis to obtain the core formula. Network pharmacology was used to collect the related targets of drugs and diseases, to construct the action network, and to conduct enrichment analysis. A total of 137 prescriptions and 167 drugs were obtained. The core prescriptions were Cortex mori, Folium eriobotryae, Scutellariae radix, Glycyrrhrizae radix, Fructus gardeniae, Radix rehmanniae, and Cortex moutan. The treatment of acne due to wind-heat in lung meridian should begin with clearing heat, purging the lung, cooling blood and detoxicating. The core prescriptions mainly played a role through AKT1, IL6, TP53, TNF, VEGFA, EGF targets and Kaposi's sarcoma-related herpes virus infection, measles, toxoplasmosis, EB virus infection, IL-17, MAPK and other signaling pathways, so as to provide reference for further clinical research.
Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by Senolytic drugs
Authors: Liu Jia , He Lian , Zhou Peng , Chen Danna
Published: June 2021

In order to study the effects of Senolytic drugs dasatinib and quercetin on the aging of mesenchymal stem cells (MSCs) and explore the application of young MSCs in repairing bone defects, the cultured and identified MSCs were treated with dasatinib and quercetin, counting the number of passage times, and the senescence of cells was evaluated by high-content screening microscopy. The 4th-passage MSCs rejuvenated with Senolytic drugs were transplanted into bone defect model rabbits, and X-ray examination was performed 12 weeks after surgery. The results showed that Senolytic drugs reduced the senility of MSCs and improved the ability of bone repair.
Comparison between SARS-CoV and SARS-CoV 2
Authors: Fang Meng
Published: June 2021

COVID-19, which is officially called SARS-CoV-2, is a newly emerging viral respiratory illness leading to a global epidemic, which causes concerns among the global community in November 2019. SARS-CoV-2 is considered as the third global coronavirus epidemic in the past 20 years after SARS-CoV in 2002 and MERS in 2012. SARS is a viral respiratory illness caused by coronavirus SARS-CoV which was first reported in Guangdong, China in 2002. SARS-CoV-2 and SARS-CoV share similar and different biological features, clinical manifestations, region distribution, transmission mechanisms, and clinical treatments. In this paper, differences and similarities between SARS-CoV-2 and SARS-CoV are analyzed to provide valuable information for further research. Through analysis, we found SARS-CoV-2 and SARSCoV share a lot of similarities, but also have differences in clinical manifestations, pathogenicity, transmission rate and treatments.
Non-invasive detection of silicosis based on array sensing and pattern recognition
Authors: Xuan Wufan , Han Zhen , Zheng Lina
Published: June 2021

Silicosis is a fibrotic lung disease caused by inhalation of silica dusts, early and accurate diagnosis of which remains a challenge. We aimed to assess the performance of a nanofiber sensor array and pattern recognition to promptly and noninvasively detect silicosis. A total of 210 silicosis cases and 430 non-silicosis controls were enrolled in a cross-sectional study. Exhaled breath was analysed by a portable analytical system incorporating an array of 16x organic nanofiber sensors. Models were established by Deep Neural Network and eXtreme Gradient Boosting. Linear Discriminant Analysis was used for dimensionality reduction and visualized data analysis. Receiver Operating Characteristic Curve, accuracy, sensitivity and specificity were used to evaluate models. Results: 99.3% AUC, 96.0% accuracy, 94.1% sensitivity, and 96.3% specificity were achieved in test set. Silicosis cases present different breath patterns from healthy controls, classification results using which were highly consistent with the experts’ diagnosis. Breath analysis performed with the sensor array and pattern recognition is expected to provide a quick, stable recognition for silicosis. In this paper, different forms of features, different algorithms and data sets over long time periods were used, which provides a reference for silicosis expiratory diagnosis scheme.
Clinical Effect and Effective Rate of Laparoscopic Cholecystectomy for Gallstones Complicated with Gallbladder Polyps
Authors: Deng Xiaoming , Jiang Jinjun
Published: June 2021

This paperA total of 62 patients with gallstones and gallbladder polyps were selected from May 2019 to May 2020, who were divided into the observation group (n=31, laparoscopic cholecystectomy) and the control group (n=31, open cholecystectomy) in a 1:1 ratio. The clinical indicators, clinical efficacy, level of pain and complication rate of the two groups were recorded and compared. Results Indicators such as the operation duration (38.64±14.42min), blood loss (30.42±8.21ml), length of stay (4.71±1.82 d), first anal exhaust (21.82±6.65min), drainage volume (72.02±4.21ml), length of incision and the time for the recovery of gastrointestinal functions in the observation group were better than the control group (P<0.05). The clinical efficacy of the observation group (96.77%) was higher than that of the control group (80.65%), with statistical value =4.0260 (P<0.05). The level of pain of the observation group was lower than that of control group (P<0.05), while the complication rate in the observation group (3.22%) was also lower than that of the control group (22.58%) (P<0.05). Laparoscopic cholecystectomy is an effective treatment of gallstones complicated with gallbladder polyps, which can alleviate pain and improve the prognosis, and is thus worthy of promotion.
How Asthma Becomes a Part of Self: Illness and Treatment Narratives Based on Patients with Chronic Diseases
Authors: Ying Qu , Yidan Zhang
Published: June 2021

Increasing people turn the sufferings of illness into human “errors” and resort to medical science and technology for remedy instead of making meaningful moral responses to illness. This is not completely effective, and it will let them fall into the dilemma of humanitarian spirit. It is necessary to pay attention to the patient’s subjective world from the perspective of illness narratives. Based on the process of patient’s disease view, the writers explored the mutual influence of disease and the subject. In light with the life course of a patient with chronic disease and the daily experience, the writers started from three aspects: the social environment of disease, the social and cultural significance of disease pain and the process of interaction between patients and asthma, in order to reveal the social and cultural characteristics of chronic disease and how the disease becomes a part of their lives. Disease is interpreted as a kind of narrative reconstruction. By connecting different aspects of life, patients can repair the fracture among their bodies, themselves and the world. It is a kind of subjective treatment that patients give meaning to their personal experience in their own way, and then understand themselves and construct new identities and life scenes.
A Relationship between vascular endothelial cell senescence and cardiovascular disease
Authors: Qing Ji-Na , Lei Yan , Bao Mei-Hua , Fu Qing-Ming
Published: June 2021

The vascular endothelial cell (VEC) is a single layer of flat squamous epithelium covering the intima of the blood vessel. It constitutes a biological barrier to the blood vessel wall. It is not only a protective barrier but also a producer of some autocrine secretion. The substance is used to regulate homeostasis and vascular tone and has a variety of biological functions. VEC senescence can lead to vascular dysfunction, which is a major risk factor for cardiovascular system (CVS) and has a close relationship with cardiovascular disease (CVD). However, the mechanism of VEC senescence and the effects of VEC senescence on vascular function are not fully understood. This review summarizes the characteristics of VEC senescence and describes age-related CVD.
Progress in anti-HER2 targeted therapy of metastatic lung cancer
Authors: Xiao Xian , Jia Yingjie
Published: June 2021

Lung cancer is one of the most common malignant tumors in the world and one of the main causes of cancer death. In lung cancer, metastatic stage accounted for a large percentage. It is a global disease affecting human health, with high incidence rate, low malignant degree and other characteristics. After decades of exploration, anti-HER2 targeted therapy in breast has made breakthrough progress, obtained encouraging clinical efficacy, and fully improved the quality of the life of patients. Because of this, more and more researchers are focusing on anti-HER2 in metastatic lung cancer targeting research. For the past few years, new targeted drugs have been constantly developed for anti-HER2 in metastatic lung cancer, and promising data results have been obtained in clinical trials and cohort study. This article provides a review of the clinical research progress of anti-HER2 targeted therapy in metastatic lung cancer in recent years, with a view to further guiding clinical treatment and providing more treatment options for patients.
Neural Stem Cells Therapy to Treat Neurodegenerative Diseases
Authors: Chen Weibai
Published: June 2021

Neural stem cells have the ability to proliferation, differentiate and renew, which plays an important role in the growth, maturation and senescence of the human brain. But according to researches, neural stem cells in the brain do not remain active throughout an organism's lifetime. Many neural stem cells become dormant when the brain matures, and may be activated when the body is sick to selectively heal the disease. In recent years, there are many studies on neural stem cells. Joshua[1] and Ting Zhang[2] show that neurodegenerative diseases such as ischemic stroke, Alzheimer's disease and Parkinson's disease can be improved by the transplantation of neural stem cells, however the specific mechanism is not clear. This paper investigates three main questions: Why neural stem cell transplantation is chosen as a treatment? Where does NSCs derive from in clinical transplantation? How does neural stem cell transplantation treat brain diseases? And we also figure out the answers to these three questions. Firstly, transplantation of hypothalamic NSCs can delay the process of aging in the host, and Chemokines and EVs which secreted by neural stem cells can delay aging and defend neurodegenerative diseases. Secondly, the sources of NSCs can be divided into three types. The first is to isolate NSCs from primary tissue and cultivate them in vitro. The second is to produce the required cells by inducing pluripotent stem cells and embryonic stem cells. The third way to get NCS is through transdifferentiation of somatic cells. Thirdly, in brain diseases, transplanted NSCs can migrate from the aggregation site to the site of the disease, reducing damage to the blood-brain barrier, repairing learning and memory abilities that depend on the hippocampus and secreting neurotrophic factors.
Preparation of polymeric aluminum ferric sulphate from waste residue of aluminum industry
Authors: jun Li , Yanmei Ju
Published: June 2021

Polymeric aluminum ferric sulphate(PAFS) was prepared from high-sulfur bauxite flotation tailings and red mud by roasting, acid leaching and polymerization. The effects of leaching temperature, leaching time, liquid-solid ratio on the leaching rate of Al3+ and Fe3+were investigated. The optimal leaching conditions are as follows: leaching temperature 100℃, leaching time 90 min, sulfuric acid concentration 4.5mol/L and liquid-solid ratio 5 mg/L. Infrared spectroscopy and X-ray diffraction analysis was carried out on the PAFS prepared under the optimum process parameters. The characterization of PAFS shows that the synthesized PAFS had polymeric aluminum, iron and hydroxyl structures. Wastewater disposal test of synthetic PAFS shows that the removal rates of COD, turbidity and chromaticity are 45.61%, 75% and 94.18%, respectively.
Effect of Fe on Nitrogen Removal Rate and Microbes of Anammox
Authors: Wang Bing , Sun Bing , Liu Yunlong , Yang Lin
Published: June 2021

With the anammox sludge as the inoculation sludge, the effect of different concentrations of Fe2+ and Fe3+ on the denitrification performance of the anammox reaction was explored by setting a control experiment.The results showed that when the Fe2+ concentration was 0.08mmol/l, the reactor had the best removal efficiency, the removal rate of NH4+-N was 89.14% after 60h, and the removal rate of NO2--N was 85.9%. The positive effect of Fe3+ on the anammox reaction was similar to that of Fe2+. From reading the literature, it can be known that Fe has a positive impact on anammox microorganisms in three aspects by promoting microbial enrichment, promoting the production of functional enzymes, and promoting microbial granulation.
Prediction Method of Wax Deposition Rate in Crude Oil Pipeline Based on RBF Neural Network and Support Vector Machine
Authors: Yu Zhang , Ruoyu Wang , Xue Wang
Published: June 2021

Wax-bearing crude oil will precipitate wax crystals in pipeline transportation, which will cause hidden dangers and affect the economic benefits of the pipeline. In order to study the complex wax deposition on the pipe wall and calculate the wax deposition under other conditions, this paper uses RBF neural network and support vector machine to predict the wax deposition data in Huachi operation area. The results show that the errors of the two methods meet the requirements. Because support vector machine can model and calculate finite samples, it is found that the accuracy of support vector machine is higher.
Comparative analysis of SOFC-MGT top-level and new bottom-level system performance
Authors: Run-Peng Qiao , Jun-Neng He , Qian-Chao Liang , Fan Yang , Da-Wang Fu
Published: June 2021

In order to make the SOFC-MGT system more widely used, the mathematical simulation models of the SOFC-MGT top-level circulatory system and the new bottom circulatory system were first established, and then the performance of the two systems was analyzed and compared using Matlab/Simulink simulation software. The research results show that the output performance of the SOFC-MGT top-level circulation system is due to the new bottom-level circulation system, and the stack output performance of the two systems is not much different.
Study on A Chinese Medicine Chewable Tablet for Anti-Alcoholism and Liver Protection
Authors: Dong Shu-Yi , Lin Jia-Yi , Yan Ni
Published: June 2021

In this study, the resources of traditional Chinese medicine were exploited reasonably, which was mainly composed of the active components of malus hupehensis and four kinds of plant components, such as Pueraria lobata, tangerine peel, jujube and corn sweet core. The preparation process of the product has been solved, and preliminary product efficacy experiments have been carried out, which has been proved to be able to relieve the symptoms of alcohol discomfort.
Application of 3D Navigation and Vascular Reconstruction Technology in Precision Resection of Lung Segment
Authors: Wu Liusheng , Li Xiaoqiang
Published: June 2021

With the rapid development of imaging technology and the improvement of people's health awareness, more early lung cancers are found. For very early lung cancer (mainly manifested as ground glass nodules), lobectomy is still the standard surgical treatment for lung cancer, and segmental resection has been used clinically as a treatment method. 3D navigation is an effective tool for precise lung segment and sub-segment resection. Three-dimensional vascular reconstruction technology is an advanced imaging technology. Accurate segment resection under thoracoscopy is considered the best surgical treatment for early stage lung cancer. It is difficult to accurately estimate the morphology, nature and other characteristics of the tumor and its surroundings by two-dimensional imaging alone. Therefore, the precise resection operation adds great difficulty and risk to the surgeon. In recent years, 3D navigation and vascular reconstruction techniques have been widely developed and applied in the medical field, and they are rarely used in thoracic surgery. This article has conducted a more in-depth study on the application of 3D navigation technology and vascular reconstruction technology in precision lung resection, and has achieved certain research results.
Study on the Application of Mildew Inhibitor in Military Warehouse Equipment Storage
Authors: Li Li , Hongqiang Zhao , weiqi Sun , Jian Ren , Wei Zhou , Kun Li , Xiaoyan Wang
Published: June 2021

Firstly, the basic conditions of the fungicide were introduced, its action principle was analyzed, the use method of the fungicide in the military warehouse was put forward, and the factors influencing the application effect were discussed.