bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Molecular Mechanism of Cinnamic Acid-Mediated Cytotoxicity in Triple Negative MDA-MB-231 Breast Cancer Cells
Authors: Pal Ambika , Tapadar Poulami , Pal Ranjana
Published: August 2020

Background:

Cinnamic Acid (CA), also known as 3-phenyl-2-propenoic acid, is a naturally occurring
aromatic fatty acid found commonly in cinnamon, grapes, tea, cocoa, spinach and celery. Various studies
have identified CA to have anti-proliferative action on glioblastoma, melanoma, prostate and lung carcinoma
cells.

Objective:

Our objective was to investigate the molecular mechanism underlying the cytotoxic effect of CA in killing
MDA-MB-231 triple negative breast cancer cells.

Methods:

We performed MTT assay and trypan blue assay to determine cell viability and cell death, respectively.
Comet analysis was carried out to investigate DNA damage of individual cells. Furthermore, AO/EtBr
assay and sub-G1 analysis using flow cytometry were used to study apoptosis. Protein isolation followed by
immunoblotting was used to observe protein abundance in treated and untreated cancer cells.

Results:

Using MTT assay, we have determined CA to reduce cell viability in MDA-MB-231 breast cancer cells
and tumorigenic HEK 293 cells but not in normal NIH3T3 fibroblast cells. Subsequently, trypan blue assay and
comet assay showed CA to cause cell death and DNA damage, respectively, in the MDA-MB-231 cells. Using
AO/EtBr staining and sub-G1 analysis, we further established CA to increase apoptosis. Additionally, immunoblotting
showed the abundance of TNFA, TNF Receptor 1 (TNFR1) and cleaved caspase-8/-3 proapoptotic
proteins to increase with CA treatment. Subsequently, blocking of TNFA-TNFR1 signalling by small
molecule inhibitor, R-7050, reduced the expression of cleaved caspase-8 and caspase-3 at the protein level.

Conclusion:

Thus, from the above observations we can conclude that CA is an effective anticancer agent that can induce
apoptosis in breast cancer cells via TNFA-TNFR1 mediated extrinsic apoptotic pathway.
A DNA Repair Pathway Polymorphism (rs25487) and Angiographically Proven Coronary Artery Patients in a Population of Southern Iran
Authors: Hoseini Seyed M. , Bijanzadeh Mahdi , Seyedian Seyed M.
Published: August 2020

Background:

Coronary Artery Disease (CAD), which is a multifactorial genetic disease,
is known as one of the most common causes of death worldwide. In this regard, X-ray Repair
Cross-Complementing group 1 (XRCC1), a DNA repair protein involved in Single-Strand Breaks
(SSBs), and Base Excision Repair (BER) pathways have been reported to be responsible for the efficient
repair of single strand breaks and damaged bases in DNA.

Objective:

In the current study, we analyzed Arg399Gln (rs25487), which is one of the most common polymorphism of
XRCC1 gene that might be associated with the increased risk for CAD.

Method:

This case-control study was performed to investigate the relationship between this polymorphism and the CAD development. In this study, 290 patients and 216 controls were diagnosed by cardiac angiography and then screened for the
above-mentioned polymorphism using Restriction Fragment Length Polymorphisms (RFLP) method.

Results:

The frequency of the GA genotype of XRCC1 Arg399Gln (rs25487) was significantly higher in CAD patients
compared to the controls (p=0.002, OR: 1.21, 95% CI: 1.06-1.37). Moreover, its dominant mode (AA + GA) genotype had a
1.851-fold increase in the risk of CAD (p = 0.005).

Conclusion:

Our findings demonstrated that Arg399Gln polymorphism of XRCC1 (rs25487) has a significant relationship
with CAD and also plays a probable predisposing role in that. Our results support the role of DNA damages and the malfunctions of DNA repair system in the patients with CAD.
Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (MetS): A Meta-Analysis
Authors: Totonchi Hamidreza , Rezaei Ramazan , Noori Shokoofe , Azarpira Negar , Mokarram Pooneh , Imani Danyal
Published: August 2020

Background:

Several studies have assessed the association between the vitamin D receptor
(VDR) polymorphism and the risk of metabolic syndrome (MetS). However, the results were inconsistent
and inconclusive. Therefore, we conducted a meta-analysis to clarify the exact association between
the vitamin D receptor (VDR) polymorphisms and the risk of MetS.

Methods:

All accessible studies reporting the association between the FokI (rs2228570) or/and TaqI
(rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232 polymorphisms of the Vitamin D Receptor
and susceptibility to MetS published prior to February 2019 were systematically searched in Web
of Science, Scopus, and PubMed. After that, Odds ratios (ORs) and their corresponding 95% confidence
intervals (CIs) were estimated to evaluate the strength of the association in five genetic models.

Results:

A total of 9 articles based on four gene variations, and comprising 3348 participants with
1779 metabolic syndrome patients were included. The overall results suggested a significant association
between BsmI (rs1544410) polymorphism and MetS susceptibility in recessive model (OR, 0.72,
95% CI, 0.55-0.95, fixed effect model), allelic model (OR, 0.83, 95% CI, 0.72-0.95, fixed effect
model), and bb vs BB (OR, 0.65, 95% CI, 0.46-0.93, fixed effect). However, no significant association
was identified between TaqI (rs731236) polymorphism, ApaI (rs7975232) polymorphism, and FokI
(rs2228570) polymorphism and MetS.

Conclusion:

This meta-analysis suggested an association between the BsmI (rs1544410) polymorphism
and MetS. Indeed, BsmI (rs1544410) acts as a protective factor in the MetS. As a result, the
VDR gene could be regarded as a promising pharmacological and physiological target in the prevention
or treatment of the MetS.
Determination of the Upper Reference Limit of Human Epididymis Secretory Protein 4 (HE4) in Healthy Male Individuals and Correlation with Renal and Fertility Markers
Authors: Schirinzi Annalisa , Cazzolla Angela Pia , Mascolo Elisa , Palmieri Giuseppe , Pesce Francesco , Gesualdo Loreto , Santacroce Luigi , Ballini Andrea , Lovero Roberto , Di Serio Francesca
Published: August 2020

Background:

Elevated human epididymis secretory protein 4 (HE4) serum levels have been widely investigated in patients with
ovarian cancer. However, high levels of HE4 can be also found in other tumors and in renal fibrosis. To date, the HE4 assay manufacturer
features the reference value only for the female pre- and post-menopausal population. The aim of this study was to determine the upper reference limit (URL) of HE4 in a well-defined and large cohort of healthy male individuals and investigate potential factors influencing HE4
levels in healthy subjects.

Methods:

The study included 307 Italian healthy male individuals. HE4 was measured using a chemiluminescent assay (Abbott Laboratories, Wiesbaden, Germany). The URL was calculated using the non-parametric percentile method. Differences in HE4 concentrations according to age, estimated glomerular filtration rate (eGFR), free and bioavailable testosterone were also evaluated.

Results:

The 97.5th percentile URL of serum HE4 in our study population was 57 pmol/L (90% CI). After stratifying subjects according to age,
we found that the URL of HE4 was higher in older (> 50 years) than in younger subjects (18-30 years old), and overlapping with the URL in
males from 31 to 50 years old (P=4.769e-16, r=0.44). A strong negative correlation between HE4 and eGFR was observed (P=8.412e-12, r=-
0.38). Moreover, a statistically significant negative correlation was also found between HE4 and free and bioavailable testosterone.

Conclusion:

In this study was determined the URL of HE4 in a large cohort of healthy male subjects. Our findings indicate that the HE4
age-dependent differences in males need to be taken into account. The definition of the HE4 URL in males and the correlation observed
with eGFR and testosterone should foster the clinical use of HE4 beyond gynecologic cancer.
Antihyperglycemic Activity of Micromeria graeca Aqueous Extract in Streptozotocin-Induced Diabetic Rats
Authors: Akdad Mourad , Azzane Amine , El Ouady Fadwa , Moujani Abdelhadi , El Khallouki Farid , Eddouks Mohamed
Published: August 2020

Aim:

This study aimed to investigate the effect of Micromeria graeca on blood glucose
levels and lipid parameters in an experimental model of diabetes.

Background:

Micromeria graeca (L.) Benth. ex Rchb is a medicinal plant used in Morocco for the
treatment of several pathologies including diabetes.

Objective:

This study aimed to evaluate the antihyperglycemic and antihyperlipidemic effects of the
aqueous extract of Micromeria graeca (M. graeca) aerial parts (AEMG) under physiological (normal
rats) and pathological (STZ-induced diabetic rats) conditions. Additionally, we analyzed the phytochemical
composition and antioxidant capacity.

Results:

Single oral administration of M. graeca aqueous extract decreased blood glucose levels 4 and
6 hours (p<0.01) after treatment in diabetic rats. In accordance, the repeated oral administration of M.
graeca showed a significant reduction in blood glucose levels in diabetic rats since the second day to
the end of the period experiment (p<0.0001). In addition, two weeks of treatment with M. graeca reduced
total cholesterol levels (p<0.05) with a significant increase of HDL-c level (p<0.01) in diabetic
rats. Moreover, M. graeca scavenged DPPH radical in a dose-dependent manner (IC50=0.48 mg/ml),
whereas IC50 was 0.55 mg/ml for BHT. Phytochemical analysis showed the richness of Micromeria
graeca on polyphenols (281.94±4.61 mg GAE/1 g), flavonoids, tannins, glycosides, saponins, sterols,
sesquiterpenes, and terpenoids.

Methods:

The effects of the acute and sub-chronic administration of AEMG (20 mg/kg) on blood glucose
levels and lipid profiles were evaluated in normal and streptozotocin-induced diabetic rats.
Moreover, the phytochemical analysis was carried with standard tests and estimation of total phenolics
compounds by Folin–Ciocalteu reagent. The antioxidant activity was realized by the DPPH method.

Conclusion:

AEMG exhibits antihyperglycemic and antihyperlipidemic activities in STZ-induced
diabetic rats and a potent antioxidant capacity.
False Measurement of Blood Amino Acids by LC-MS/MS in a Patient Dependent on Matrix Effect after Total Parenteral Nutrition Infusion
Authors: Guzelcicek Ahmet , Gönel Ataman , Demir Abit , Koyuncu Ismail
Published: August 2020

Background and Aim:

Although it is widely known that the total parenteral nutrition (TPN)
used frequently in intensive care units has unwanted side effects, there is little known about how it
interferes with the amino acid levels taken during the diagnosis of metabolic diseases. Amino acid can
lead to inaccurate measurements with mass spectrometry due to its high molecular content of lipids and
carbohydrates, which modifies the blood matrix. The purpose of this study was to emphasize the results
of amino acid interference, measured with mass spectrometry, in patients administered with TPN.

Case Presentation:

Incorrect clinical interpretation resulted in the case of a pneumonia patient with
false positive and negative blood amino acid levels caused by TPN infusion. The amino acid profile
had been requested to rule out an amino acid metabolic defect in the two-year-old boy who arrived at
the pediatric clinic complaining of respiratory distress, tachypnea and hypoxemia. He was monitored in
the intensive care unit for further investigation. The personnel who had performed phlebotomy also
carried out the sampling during the TPN infusion administration. This caused the amino acid results
and an incorrect interpretation. The following deviation ratios were detected: phenylalanine 102%,
leucine 86%, isoleucine 106%, GABA 200%, citrulline 238%, glutamine 178%, ornithine 216%, 1-
methyl-l-histidine 1471%, serine 312%, alanine 163%, glycine 355%, homocitrulline and carnosine
444%. The amino acid blood level measurements taken for diagnosis and screening in suspected metabolic
disease may lead to involuntary false low or elevated results in patients administered with TPN.

Conclusion:

This case demonstrates that TPN solutions affect the reference method of mass spectrometry
measurement methods due to the concentration of ingredients. We suggest that inaccurate
results can be avoided by carrying out the sampling prior to TPN infusion in patients whose plasma
amino acid levels will be measured.
Impact of MWCNT and GF Incorporation on Optical Properties of GTS Alloy
Authors: Singh Abhay Kumar , Jen Tien-Chien
Published: August 2020

Aims:

To address the physical properties of the growing research topic based on inorganic
and organic composite materials under the glassy regime. The incorporation of a small amount of organic
content in inorganic chalcogenide alloy could be an interesting topic for the investigation. Such
composite materials' optical and structural properties could define their prospective use.

Objectives:

Considering the prospective utility of the inorganic and organic composite materials, this
report’s key goal was to demonstrate the structural and optical properties, like, absorption spectra, extinction
coefficient (k), real dielectric constant (εʹ), imaginary dielectric constant (εʹʹ), refractive index
(n), absorption coefficient (α) and optical energy band (Eg ) for the Se 55 Te 25 Ge 20 (GTS) alloy,
Se 55 Te 25 Ge 20 +0.025% multiwalled carbon nano tubes (MWCNT) and Se 55 Te 25 Ge 20 +0.025 %
bilayer graphene (GF) composites.

Methods:

To synthesize the materials, a direct melt-quenched technique was adopted. Materials microstructural
and UV/Visible optical absorption were performed from the Field Emission Scanning
Electron Microscope and UV/Visible optical spectrometer equipment’s.

Results:

The obtained experimental evidences revealed that materials’ optical properties and microstructures
slightly altered owing to the incorporation of multi walled carbon nano tubes and bilayer
graphene in Se 55 Te 25 Ge 20 regime. To correlate the inorganic-organic material interactions, a schematic
has also interpreted based on the bond formation in the solids.

Conclusion:

The experimental evidences have revealed the existence of MWCNT and GF in diffused form in GTS glassy configuration.
The evidences have also revealed the diffused morphologies of the MWCNT and GF could not developed the specific structure within the
complex configuration (although they have exhibited rather distinct morphologies), but they influenced the optical properties of the
composite materials.
Exploration of Novel Formulations for the Treatment and Diagnosis of Cancer
Authors: Raj Shakshi , Kumar Vinay , Kala Nidhi , Malviya Rishabha , Sharma Akanksha , Sharma Pramod K. , Gupta Ramji
Published: August 2020

:

The biological applications of nanoparticles have been rapidly advancing in the field of
cancer detection and its treatment. Many drug delivery systems have been developed and some are
still developing based on the concept of nanotechnology for cancer diagnosis. These unique systems
have the potential to diagnose, treat and reduce the chances of cancer. Some captivating
fields with many applications have been developed when nanotechnology is combined with biotechnology.
In this review, many systems have been described, which are based on nanotechnology
used to treat cancer. Carbon nanotubes, aptamer, polymersomes, dendrimers, nanoshells and
many more have been described in this review. Cancers like brain cancer, lung cancer and breast
cancer have been explained with their method of treatment. The review also focuses on the advantage
of the different types of systems based on nanoparticles with their application in the treatment
of cancer.
Zinc Oxide Nanoparticles: A Biological and Pharmaceutical Review
Authors: Raj Behin Sundara , Samraj Punitha Isaac
Published: August 2020

Zinc oxide (ZnO) is a metal oxide well known for its photocatalytic property and is
widely used in cosmetics. Lately, it has gained more importance in its biomedical applications, especially
in cancer therapy. Scientific works have elucidated the efficiency of ZnO nanoparticles
(NPs) against different cancer cell lines. There are safety concerns related to the usage of ZnO NPs
as the zinc ion concentration may lead to changes in the human body. This review covers the significant
pharmaceutical and biological aspects of ZnO NPs. Besides, this review updates ZnO NPs
revolutionary use in photodynamic therapy (PDT), where it can work wonders and pave the way
for novel therapeutic approaches against cancer.
A Recent Review on Drug Modification Using 1,2,3-triazole
Authors: Sahu Adarsh , Sahu Preeti , Agrawal Ramkishore
Published: August 2020

Motivated by evidence garnered from literature probing the use of triazoles in drug discovery and development, we reported the utilization of bioisosteric replacement and molecular hybridization in this review. Bio-isosteric replacement has played a significant role in modulating rapid and versatile strategy in synthesizing molecules with multifaceted medicinal properties. Molecular hybridization seeks to conjugate two molecular fragments with diverse applications under very mild reaction conditions. In this regard, 1,2,3-triazole is a well-known scaffold with widespread occurrence in medicinal compounds. It is characterized to have several bioactivities such as anti-microbial, anti-cancer, anti-viral, analgesic, anti- inflammatory effects. Furthermore, the structural features of 1,2,3-triazoles enable it to mimic different functional groups justifying its use as bio-isostere for the synthesis of new molecules of medicinal interest, which we have reported briefly.
Hydrogen Peroxide and Quercetin Induced Changes on Cell Viability, Apoptosis and Oxidative Stress in HepG2 Cells
Authors: Yılmaz Ayşe Mine , Biçim Gökhan , Toprak Kübra , Yılmaz Betül Karademir , Milisav Irina , Yalçın Ahmet Suha
Published: August 2020

Background:

Different cellular responses influence the progress of cancer. In
this study, the effects of hydrogen peroxide and quercetin induced changes on cell
viability, apoptosis, and oxidative stress in human hepatocellular carcinoma (HepG2)
cells were investigated.

Methods:

The effects of hydrogen peroxide and quercetin on cell viability, cell cycle
phases, and oxidative stress related cellular changes were investigated. Cell viability was
assessed by WST-1 assay. Apoptosis rate, cell cycle phase changes, and oxidative stress
were measured by flow cytometry. Protein expressions of p21, p27, p53, NF-Kβ-p50,
and proteasome activity were determined by Western blot and fluorometry, respectively.

Results:

Hydrogen peroxide and quercetin treatment resulted in decreased cell viability
and increased apoptosis in HepG2 cells. Proteasome activity was increased by hydrogen
peroxide but decreased by quercetin treatment.

Conclusion:

Both agents resulted in decreased p53 protein expression and increased cell
death by different mechanisms regarding proteostasis and cell cycle phases.
Improving Patient Prioritization During Hospital-Homecare Transition: Protocol for a Mixed Methods Study of a Clinical Decision Support Tool Implementation
Authors: Zolnoori Maryam , McDonald Margaret V , Barrón Yolanda , Cato Kenrick , Sockolow Paulina , Sridharan Sridevi , Onorato Nicole , Bowles Kathryn , Topaz Maxim
Published: August 2020

Background

Homecare settings across the United States provide care to more than 5 million patients every year. About one in five homecare patients are rehospitalized during the homecare episode, with up to two-thirds of these rehospitalizations occurring within the first 2 weeks of services. Timely allocation of homecare services might prevent a significant portion of these rehospitalizations. The first homecare nursing visit is one of the most critical steps of the homecare episode. This visit includes an assessment of the patient’s capacity for self-care, medication reconciliation, an examination of the home environment, and a discussion regarding whether a caregiver is present. Hence, appropriate timing of the first visit is crucial, especially for patients with urgent health care needs. However, nurses often have limited and inaccurate information about incoming patients, and patient priority decisions vary significantly between nurses. We developed an innovative decision support tool called Priority for the First Nursing Visit Tool (PREVENT) to assist nurses in prioritizing patients in need of immediate first homecare nursing visits.

Objective

This study aims to evaluate the effectiveness of the PREVENT tool on process and patient outcomes and to examine the reach, adoption, and implementation of PREVENT.

Methods

Employing a pre-post design, survival analysis, and logistic regression with propensity score matching analysis, we will test the following hypotheses: compared with not using the tool in the preintervention phase, when homecare clinicians use the PREVENT tool, high-risk patients in the intervention phase will (1) receive more timely first homecare visits and (2) have decreased incidence of rehospitalization and have decreased emergency department use within 60 days. Reach, adoption, and implementation will be assessed using mixed methods including homecare admission staff interviews, think-aloud observations, and analysis of staffing and other relevant data.

Results

The study research protocol was approved by the institutional review board in October 2019. PREVENT is currently being integrated into the electronic health records at the participating study sites. Data collection is planned to start in early 2021.

Conclusions

Mixed methods will enable us to gain an in-depth understanding of the complex socio-technological aspects of the hospital to homecare transition. The results have the potential to (1) influence the standardization and individualization of nurse decision making through the use of cutting-edge technology and (2) improve patient outcomes in the understudied homecare setting.

Trial Registration

ClinicalTrials.gov NCT04136951; https://clinicaltrials.gov/ct2/show/NCT04136951

International Registered Report Identifier (IRRID)

PRR1-10.2196/20184
CONDIÇÕES DE TRABALHO DO PROFESSOR DE ARTE DO ENSINO MÉDIO EM SANTA CATARINA
Authors: Carvalho Josué , Costa Gilvan
Published: August 2020

Este artigo é um recorte de uma pesquisa realizada para uma dissertação defendida em Mestrado em Educação. O objetivo geral é conhecer as condições de trabalho do professor de Arte do Ensino Médio das escolas estaduais catarinenses, notadamente a infraestrutura das escolas, o tipo de vínculo de trabalho que este professor tem, sua carreira, remuneração e o esforço docente. O método selecionado para a pesquisa foi o de perspectiva dialética, e os resultados apontam que os professores do Ensino Médio têm jornadas de trabalho intensas e extensas, e a Educação socialmente referenciada está para ser alcançada em Santa Catarina, mas parece distanciar-se cada vez mais dela. A reforma no Ensino Médio  distancia-se da formação integral, com a qualidade socialmente referenciada, e nos leva a perceber que parece haver um projeto de sociedade direcionado a sonegar a formação integral dos jovens em nosso país, pois a qualidade socialmente referenciada parece estar longe, bem longe de ser alcançada.
Peran Unit Khidmat Dan Nasihat Keluarga Jabatan Agama Islam Kedah Dalam Upaya Menurunkan Angka Perceraian (Studi Kasus di Jabatan Agama Islam Kedah, Malaysia)
Authors: Daud Mohd Kalam , Mohd Nazly Mohd Irfan Najmy Bin
Published: August 2020

Unit Khidmat dan Nasihat Keluarga merupakan sebuah lembaga khusus yang bertujuan menyelesaikan perselisihan keluarga. Tujuan unit ini agar masalah kekeluargaan dapat diatasi pada peringkat awal supaya hubungan suami istri kembali baik dan harmonis. Namun, peran unit ini dalam menyelesaikan sengketa keluarga didapati kurang berpengaruh hingga mengakibatkan meningkatnya kasus perceraian di Negeri Kedah. Penelitian ini bertujuan untuk menjawab dari permasalahan pokok, yaitu bagaimana peran Unit Khidmat dan Nasihat Keluarga dalam menurunkan angka perceraian dan apa saja dukungan dan hambatan yang dihadapi oleh Unit Khidmat dan Nasihat Keluarga dalam menyadarkan masyarakat maupun pasangan itu sendiri mengenai perceraian dan persengketaan rumah tangga. Penyusunan skripsi ini menggunakan metode penelitian kepustakaan (library research) dan penelitian lapangan (field research) dengan mengambil data primer dan data sekunder. Kedua data tersebut penulis akan menganalisis dengan menggunakan metode deskriptif analisis. Penulis melakukan wawancara dan dokumentasi untuk menghasilkan data mengenai peran Unit Khidmat dan Nasihat Keluarga Jabatan Agama Islam Kedah dalam Upaya Menurunkan Angka Perceraian. Berdasarkan hasil penelitian yang diperoleh menunjukan bahwa unit ini berusaha menyadarkan masyarakat mengenai masalah perceraian dan sengketa rumah tangga dengan memberikan ilmu pengetahuan melalui pelaksanaan kursus pra perkawinan dan pemantapan pasca perkawinan yang mana di dalamnya terdapat beberapa seminar kekeluargaan untuk membina keluarga bahagia dan menitikberatkan hak dan kewajiban antara suami istri. Kesimpulannya, unit ini melaksanakan perannya sebagai mediator atau konsultan dengan memberi saran dan nasihat yang baik dalam proses mediasi dan berusaha untuk menyedarkan masyarat mengenai sengketa rumah tangga.
Nikah Tanpa Izin Pengadilan Menurut Enakmen Undang-Undang Keluarga Islam Negeri Terengganu 2017 (Studi Kasus Di Daerah Kualla Terengganu, Negeri Terengganu, Malaysia)
Authors: Khairuddin Khairuddin , Mohamad Angkashah Muhammad Haiqal Bin
Published: August 2020

Izin pengadilan dan prosedur perkawinan tidak menjadi salah satu syarat sah pernikahan dalam Islam. Namun realitasnya masa kini, menjadi satu keharusan agar pihak Mahkamah Syari’ah dapat memeriksa setiap persyaratan yang perlu dipenuhi setiap pihak dalam pernikahan itu, baik syarat sudah terpenuhi ataupun belum, sesuai dengan ketentuan Enakmen Undang-Undang Keluarga Islam Negeri Terengganu 2017 (EUKI Terengganu 2017). Pertanyaan penelitian dalam skripsi ini adalah bagaimana profil nikah tanpa izin pengadilan serta bentuk sanksi yang dikenakan kepada pelaku nikah tanpa izin pengadilan menurut EUKI Terengganu 2017 dan apakah faktor dan dampak hukum yang terjadi kepada pihak yang terlibat dalam nikah tanpa izin pengadilan ini. Penyusunan skripsi ini menggunakan metode penelitian kepustakaan (library research) dan penelitian lapangan (field research) dengan mengambil data primer dan data sekunder. Hasil penelitian ditemukan bahwa terdapat empat Seksyen (Pasal) dalam EUKI Terengganu 2017 yang membincangkan perihal nikah tanpa izin pengadilan yaitu, Seksyen 126, Seksyen 35, Seksyen 37, dan Seksyen 36 EUKI Terengganu 2017. Jika dilihat kasus-kasus yang pernah terjadi, faktor yang mempengaruhi suatu pasangan itu untuk mengambil jalan mudah menikah adalah poligami,  wali adhlal, prosedur kawin di Malaysia yang rumit dan ketat, sindikat kawin lari, dan masalah sosial. Dari paparan di atas dapat disimpulkan bahwa terdapat kelemahan di dalam EUKI Terengganu khususnya berkaitan dengan sanksi kesalahan itu yang mana sanksinya tidak berat dan penguatkuasaan dalam memberikan hukuman itu tidak semaksimal mungkin. Sanksi yang dihukumkan tidak memberi pengajaran dan dianggap tidak sesuai dengan taraf hidup masyarakat Terengganu sekarang yang jauh berkemampuan dalam membayar sanksi-sanksi tersebut. Oleh karena itu, EUKI Terengganu 2017 ini perlu dimodifikasi khususnya pada sanksi-sanksinya supaya pelanggaran EUKI Terengganu 2017 dapat diatasi dan sosialisasi tentang nikah tanpa izin pengadilan lebih diperkuatkan lagi kepada masyarakat agar dapat membuka pengetahuan kepada masyarakat sekaligus memberikan kesadaran dari peringkat awal lagi.
Pencabutan Hak Hadhȃnah Terhadap Istri Yang Berzina Berdasarkan Perspektif Tarjih Maşhlahah (Analisis Putusan Hakim Tingkat Banding Nomor: 59/Pdt.G/2017/MS-Aceh)
Authors: Fahmi Mutiara , Syuib Muhammad , Arnanada Yunita
Published: August 2020

Salah satu konsekuensi akibat adanya perceraian yaitu hadhânah. Jadi terjadi perceraian anak yang belum mumayyiz adalah hak ibu sebagai pemegang hadhânah. Ada beberapa syarat yang harus terpenuhi bagi perempuan pengasuh, jika salah satu syarat tidak terpenuhi maka gugur hak  hadhânah terhadapnya. Syaratnya ialah: Islam, baligh, berakal sehat, memiliki kemampuan untuk mendidik anak, amanah, berbudi pekerti yang baik. Namun bagaimana jika istri berzina dengan laki-laki lain apakah ia masih berhak diberikan hadhânah atau tidak. Dalam putusan hakim tingkat banding di Mahkamah Syar’iyyah Aceh Nomor 59/Pdt.G/2017/MS-Aceh masih memberikan hak hadhânah kepada istri yang berzina. Oleh sebab itu penulis skripsi ingin mengetahui bagaimana dasar pertimbangan Mejelis Hakim Mahkamah Syar’iyyah Aceh memberikan hadhânah kepada istri yang berzina dan bagaimana kesesuaian putusan hakim Mahkamah Syar’iyyah Aceh tersebut jika ditinjau dalam perspektif tarjih maşhlahah. Dalam penelitian ini, penulis menggunakan metode yuridis normatif yang bersifat kualitatif. Hasil penelitian yang temukan ialah Pertimbangan Hakim Mahkamah Syar’iyyah Aceh tetap memberikan hadhânah kepada ibu didasari atas hakim marujuk pada Pasal 105 KHI yang menyatakan “dalam hal terjadinya perceraian, pemeliharaan anak yang belum mumayyiz atau belum berumur 12 tahun adalah hak ibunya”. Kemudian, Majelis hakim tingkat banding mempelajari lagi pada putusan tingkat pertama, bahwa menurut keterangan saksi yang diajukan oleh para pihak tidak ada yang menyatakan jika istri berzina dengan laki-laki lain, dan suami tidak memiliki bukti yang dapat menguatkan argumentasi yang menyatakan kalau istri berzina dengan laki-laki lain, oleh karena itu Majelis hakim tingkat banding tidak dapat mencabut hak hadhânah terhadap istri. Jika ditinjau dari perspektif tarjih maşhlahah, putusan  Majelis Hakim Mahkamah Syar’iyyah sudah tepat dalam memberikan hadhânah kepada istri. Hakim dalam memutuskan perkara hadhânah disini beralih kepada aturan yang terdapat dalam Kompilasi Hukum Islam Pasal 105, dikarenakan istri tidak dapat dibuktikan bahwa ia berzina dengan laki-laki lain dan istri juga belum menikah dengan laki laki lain. Oleh karena itu hakim menetapkan hadhânah kepada istri yang berzina tetap mengutamakan kemashlahatan dengan cara mengambil kemudaratan yang paling ringan.
Pengaruh Pernikahan Orangtua yang Kedua terhadap Keharmonisan Keluarga: Studi Kasus di Desa Ladang Tuha Kecamatan Pasie Raja
Authors: Sabil Jabbar , Syafrizal Syafrizal
Published: August 2020

Pernikahan dilakukan untuk meraih keharmonisan rumah tangga. Namun, tidak semua orang yang melakukan pernikahan dapat merasakan kebahagian atau harmonis dalam keluarga namun ada juga menyebabkan Disharmoni hingga sampai mengalami pertengkaran yang terjadi disebabkan karena selisih paham dalam menyelesaikan persoalan lika-liku kehidupan, sehingga menuju sampai kejenjang perceraian, fenemona itu sangat disayangkan karena perbuatan perceraian tersebut merupakan suatu hal yang sangat dibenci oleh Allah, penulis sangat heran jika di daerah desa Ladng Tuha khususnya  dan di daerah Aceh umumnya yang kita ketahui orangnya sangat taat dengan agama dan patuh pada syari’at yang berlaku namun angka kasus perceraian tiap tahunnya semakin meningkat dari tahun 2017 ada 4.917 kasus dan tahun 2018 meningkat menjadi 5.562 diseluruh kabupaten/kota se aceh semua itu sudah diputuskan di Mahkamah Syar’iyah se-wilayah hukum Mahkamah Syar’iyah Aceh. Oleh sebab itu, Artikel ini membahas tentang poblematika yang terjadi dalam keluarga. Dalam menulis ini penulis  melakukan metode penelitian dengan cara kualitatif.
Pengukuran Arah Kiblat Menggunakan Alat Modern menurut Perspektif Ulama Dayah (Studi Kasus di Kabupaten Pidie)
Authors: Daud Mohd Kalam , Sunardy Ivan
Published: August 2020

Penentuanan arah kiblat kembali mencuat dan menghangat di Indonesia, khususnya di Aceh seiring bertepatan dengan yaum rashdi al-kiblat (hari meluruskan arah kiblat) terjadi pada 28 Mei dan 16 Juli 2017. Temuan tim Kementerian Agama (Kemenag) Pidie menjelaskan bahwa masih terdapat daerah  yang arah kiblatnya tidak sesuai (mengarah ke ka’bah) di Kabupaten tersebut. Hal  ini diketahui setelah dilakukan pengecekan kembali (cross check) arah kiblat dengan menggunakan alat  modern. Akan tetapi, hasil tersebut menimbulkan  reaksi penolakan dari sebagian ulama dayah atau teungku di Kabupaten tersebut. Sebab,  cara pengukuran arah kiblat oleh tim Kemenag Pidie dilakukan dengan menggunakan alat modern. Oleh karena penulis tertarik untuk melakukan penelitian untuk mengetahui teknik dan perspektif ulama daya dalam hal pengukuran arah kiblat dengan menggunakan alat modern. Penelitian menggunakan pendekatan kualitatif dalam pengumpulan data, dan teknik yang digunakan adalah wawancara dengan sebagian ulama dayah. Hasil penelitian ini menunjukkan bahwa ada beberapa mesjid dan mushalla di Kabupaten Pidie arah kiblatnya kurang tepat mengarah ke Ka’bah karena teknik dan alat pengukuran yang digunakan pada waktu itu masih sangat tradisional dan hasil yang didapatkan kurang akurat serta tidak memperhitungkan menit dan detik busur derajat, sehingga setelah mesjid berdiri beberapa tahun dan diukur dengan menggunakan metode dan alat yang akurat maka hasilnya terjadi perbedaan sudut arah kiblat dengan arah kiblat yang telah ditentukan sebelumnya. Mayoritas teungku-teungku (ulama dayah) di Kabupaten Pidie menerima dengan baik metode pengukuran dan ketepatan hasil penentuan arah kiblat menggunakan alat modern yang dilakukan oleh Tim BHR Kabupaten maupun Provinsi sebagai tenaga ahli yang berkompeten di bidangnya. Hal ini dikarenakan metode dan alat yang digunakan oleh Tim BHR merupakan metode ilmiah dan alat yang digunakan dapat menentukan arah kiblat secara tepat.
Pemenuhan Nafkah Keluarga dengan Bekerja di Bank Konvensional: Suatu Pendekatan Maqashid Syariah
Authors: Hamid Asrul , Putra Dedisyah
Published: August 2020

Studi ini membahas tentang hukum bekerja pada  Bank Konvensional sebagai upaya pemenuhan nafkah keluarga ditinjau dari pendekatan maqashid syariah. Pada satu sisi dalam memenuhi nafkah keluarga, terkadang seseorang bekerja di bank konvensional, akan tetapi praktik dalam perbankan konvensional tidak terlepas dari riba yang diharamkan dalam Islam, sementara nafkah keluarga harus dipenuhi demi menjaga eksistensi kehidupan. Hasil penelitian menyimpulkan bahwa pada dasarnya bekerja di Bank Konvensional hukumnya adalah diharamkan akan tetapi ketika keadaan terpaksa untuk memenuhi nafkah keluarga dan kemaslahatan untuk menjaga eksistensi kehidupan agar tidak terancam, maka hukumnya makruh dengan syarat tetap berupaya mencari pekerjaan lain yang dibolehkan Islam.
INTERFACES ENTRE GÊNERO E SAÚDE MENTAL ABORDADAS POR ESTUDOS QUALITATIVOS DAS CIÊNCIAS SOCIAIS E HUMANAS: FOCO NAS EXPERIÊNCIAS SUBJETIVAS
Authors: Meneses Alves Tahiana
Published: August 2020

O presente trabalho consiste em uma revisão de literatura do tipo narrativa que tem por objetivo destacar produções brasileiras de cunho empírico que englobam o gênero enquanto categoria analítica no campo da saúde mental. Possui como recorte estudos qualitativos que focalizam as experiências subjetivas face a própria saúde mental. Os estudos foram identificados através de base de dados como a Scielo e a Biblioteca Digital Brasileira de Teses e Dissertações. A revisão evidencia a necessidade de mais estudos que considerem as perspectivas das pessoas face a própria saúde mental levando em conta uma abordagem de gênero; constata a escassez de estudos sobre a saúde mental masculina; demonstra que condições desiguais de gênero diferenciam as formas de adoecer entre homens e mulheres, bem como produzem impactos distintos para eles e elas em diversas esferas da vida. Aponta para a importância do registro e da análise sobre como as pessoas elaboram diferentes sentidos em torno de suas experiências de saúde mental para além de perspectivas biologicistas.
SOBRE HOMENS, CÂNCER DE PRÓSTATA E SAÚDE: UM ENSAIO A LUZ DA ANTROPOLOGIA DAS MASCULINIDADES
Authors: Santos Araújo Jeferson , Maria Fontão Zago Márcia
Published: August 2020

Este estudo oferece uma visão sobre a influência das masculinidades frente ao ajustamento dos homens à doença e aos tratamentos para o câncer de próstata (CP). Trata-se da síntese de uma tese de doutorado a qual foi desenvolvida pela perspectiva qualitativa, adotando como método a etnografia narrativa e o referencial teórico da Antropologia Médica. Participaram do estudo 17 homens diagnosticados em seguimento terapêutico em um hospital universitário localizado no interior do estado de São Paulo. Duas unidades temáticas ilustram os significados das experiências investigadas: enredos corporificados do câncer de próstata: normas, conflitos e descobertas; e masculinidades resignadas em tempos de crise: como nos vemos, enfrentamos e seguimos no nosso mundo social. Foi possível identificar que a cultura influenciou na experiência do homem adoecido pelo CP, transformando seu corpo biológico, social e sua masculinidade.
“OLHARES TORTOS” - UM ESTUDO COM MOTORISTAS DE ÔNIBUS DA CIDADE DE PORTO VELHO-RO
Authors: Dal Castel Schlindwein Vanderleia de Lurdes , Selleri Bezerra Gabrielle
Published: August 2020

Este estudo teve como objetivo compreender as dificuldades das mulheres que trabalham como motorista de ônibus na cidade de Porto Velho – RO, suas condições de trabalho e enfrentamentos com os colegas homens. Trata-se de uma pesquisa de cunho qualitativo com cinco mulheres motoristas de ônibus de uma empresa de transporte coletivo da cidade de Porto Velho. Para a realização das entrevistas, foi utilizado um roteiro de questões semiestruturadas. As motoristas descrevem que já vivenciaram situações de discriminação de gênero por parte de passageiros em suas rotinas de trabalho. Por parte dos colegas de trabalho, os preconceitos mostram-se velados nas brincadeiras.
UMA EXPERIÊNCIA COM GRUPOS DE PROMOÇÃO DA SAÚDE MATERNO-INFANTIL NO SISTEMA PRISIONAL
Authors: Savaris Ignácio Gabriel
Published: August 2020

Os presídios brasileiros representam uma complexa questão de saúde pública na qual as mulheres caracterizam-se como uma população bastante vulnerável devido às especificidades de saúde, gênero e maternidade. Através de um relato de experiência, analisou-se grupos de promoção da saúde em uma Unidade Materno Infantil de uma penitenciária feminina do Rio Grande do Sul. Os resultados possibilitaram uma compreensão sobre os obstáculos no acesso às políticas públicas, do exercício da maternidade e da vida nesse contexto. Além disso, indicaram dispositivos terapêuticos para promoção da saúde e de articulação de saberes entre usuárias e trabalhadores/as do Sistema Único de Saúde.
FEMINISMOS E ESPAÇO PÚBLICO: MULHERES NA DIPLOMACIA BRASILEIRA
Authors: Soares Balestero Gabriela
Published: August 2020

O presente estudo busca compreender as perspectivas feministas e representatividade política feminina na Diplomacia Brasileira. A participação de mulheres na política precisa ser discutida, visto que, em um mundo no qual as injustiças e lutas por igualdade não se restringem apenas ao âmbito doméstico, a participação paritária e representativa das mulheres no espaço público é uma exigência para o avanço da promoção da igualdade de gênero. Assim, o artigo científico pretende analisar teoricamente uma política que traduza as ideias de democracia e inclusão, visto que ainda há baixa presença de mulheres na estrutura de comando do Itamaraty.
PRÁTICAS CRIMINOSAS, PRÁTICAS EGOÍSTAS, PRÁTICAS PROIBIDAS: O ABORTO NO DISCURSO DO MÉDICO NINO MAGNO BAPTISTA, 1930
Authors: Garabely Heil Vázquez Georgiane , Loch Fernanda
Published: August 2020

O objetivo central desse artigo é apresentar o discurso de Nino Magno Baptista, presente na fonte analisada, sobre as mulheres e as práticas de aborto numa perspectiva histórica, destacando a década de 1920. A metodologia de análise foi colocada a partir de um estudo de caso, e de análise de discurso sobre uma tese médica. Ela foi apresentada na Faculdade de Medicina da Bahia, e publicada em 1930. A tese intitulada “Estudo medico social do aborto” coloca à prova a moral feminina, além de apresentar um suposto papel social das mulheres ao longo do tempo.
ROSANA PAULINO: ARTE, CRÍTICA, SUBJETIVIDADE
Authors: Dionísio Gustavo , Sugawara Gisele
Published: August 2020

Visamos abordar questões relacionadas aetnicidade e gênero na produção de arte contemporânea no Brasil tomando como exemplo certas obras de Rosana Paulino (1967) que, particularmente, tematiza tais problemáticas ao tecer duras críticas ao racismo e ao machismo cotidianos. Trata-se de significativa valorização da poética afro-brasileira, assim como um resgate da história das mulheres negras no Brasil. Surge, tendo em vista que o campo da arte é produtor de subjetividade, uma forma de fazê-la atrelada ao feminismo e antirracismo, isto é, toda uma dimensão necessariamente ético-política que ronda as criações da artista.
UMA EVIDÊNCIA DA DISCRIMINAÇÃO SALARIAL NO ESTADO DO RIO GRANDE DO SUL
Authors: Becker Kalinca Leia , Ramos da Silva Neto Darcy , Cavalheiro Krauzer Fernando
Published: August 2020

O objetivo principal desse estudo é analisar as diferenças salariais de gênero e etnia no Estado do Rio Grande do Sul. Para isso, foram estimadas equações de rendimentos com base nas informações da PNAD (2015). Os resultados indicaram que, em média, os homens recebem um salário/hora 18,41% maior em relação às mulheres. Já as pessoas autodeclaradas da cor branca recebem, em média, 9,58% a mais por hora de trabalho. A vantagem salarial desses grupos também é observada quando são considerados indivíduos com o mesmo nível educacional.
Screening for Mental Health Comorbidities in a Pediatric Diabetes Clinic Setting
Authors: Roberts Alissa J. , Barry Dwight , Yi-Frazier Joyce , Rutman Lori , Pihoker Catherine , Malik Faisal Saleem
Published: August 2020

Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes an effort to improve mental health screening of patients at a pediatric diabetes clinic in Seattle, WA.
Health Care Transition in Youth With Type 1 Diabetes and an A1C >9%: Qualitative Analysis of Pre-Transition Perspectives
Authors: Tremblay Elise Schlissel , Ruiz Jessica , Buccigrosso Tess , Dean Taylor , Garvey Katharine
Published: August 2020

OBJECTIVE | To explore expectations for transition to adult care and experiences with transition planning among adolescents and young adults with type 1 diabetes and an A1C >9% at a tertiary care U.S. pediatric center.

METHODS | We conducted semi-structured interviews in a purposive sample of patients 14–23 years of age who had had type 1 diabetes for at least 1 year and had an A1C >9%. A multidisciplinary team conducted iterative thematic analysis with deductive and inductive coding aided by NVivo software.

RESULTS | Fourteen subjects participated (nine adolescents and five young adults, mean age 17.1 ± 3.2 years, 57% male, 79% Caucasian, 14% Hispanic, diabetes duration 8.2 ± 4.6 years, mean A1C 10.0 ± 0.8% for adolescents and 10.1 ± 0.7% for young adults). Qualitative analysis yielded four key themes. The first was lack of formal preparation; participants of all ages demonstrated a lack of preparation for transition and ignorance about the process, describing it as coming “out of the blue.” The second was a desire for delayed and gradual transition; participants wanted to defer being “serious” about transition to a later/uncertain date, with a preference to “wait until I’m older” among all ages. Participants described ideal transition as a gradual process, taking place “a little at a time.” The third was attachment to pediatric providers; participants demonstrated a nearly universal attachment to and “familiarity” with their pediatric diabetes care providers and expressed worries about an “uncomfortable” transition to adult providers. The fourth was concern about an impersonal adult care setting: participants perceived adult care as “formal,” “scarier,” and “tougher,” with increased criticism about poor control; participants expressed fear that adult providers would not “know me” or appreciate “my diabetes journey.”

CONCLUSION | We demonstrated a lack of transition preparation and anxiety about transition and adult care among youth with type 1 diabetes and elevated A1C. Our results may help guide early, iterative pediatric transition counseling, with a special focus on addressing attachment and fears about adult diabetes care.
Effect of the Ceramic Burning Temperature on the Characteristics of the Emission Spectrum (LIBS) of Al and Transmittance (FTIR) of Al-O on Ceramic Body of BL-1 Type
Authors: Wendri Nyoman , Krisandi Aprilion , Irawan I Gusti Putu Yoyok
Published: August 2020

Aluminum (Al) contained in materials such as clay, kaolin is one of the elements that play an important role in the ceramic body. Al binds to other atoms like Si (quartz) to form a ceramic frame that is strong and not easily cracked. In addition, the bond with the group -OH plays an important role in relation to the ability of ceramics to absorb water. In this study, BL-1 type ceramic samples have been made with five variations of the burning temperature between 800-1000oC. To determine changes in the Al atomic content of ceramic samples were characterized by LIBS and FTIR spectrophotometers. The results of LIBS characterization of all samples showed two bands with peaks at wavelengths of 394.4 nm (Al-I) and 396.6 nm (Al-II) which are the characteristic peaks of Al atoms. The peaks with the highest intensity of Al-I and Al-II were resulted by samples that were burned at 900oC. Meanwhile, the results of FTIR characterization have shown a spectrum with bands at wavenumbers between 1030-1060 and 1150 cm-1 which are characteristic bands of stretching vibrations from Al-O. The peak of the band in the wavenumber between 1030-1060 cm-1 shifts towards a larger wavenumber with increasing the burning temperature.
Pemilihan Pakan Alami Untuk Mendukung Pemeliharaan Ikan Capungan Banggai (Pterapogon kauderni) Di Lini Aquaculture Training Center (Latc) Bali
Authors: Hulu Hasrat Damai , Julyantoro Pande Gde Sasmita , Kasa I Wayan
Published: August 2020

Tujuan dari penelitian ini adalah untuk mendapatkan jenis pakan alami yang tepat dan dosis pemberian pakan yang optimal untuk mendukung pemeliharan ikan capungan banggai. Penelitian dilakukan dengan Rancangan Acak Lengkap (RAL), dan dilaksanakan pada bulan September-Desember 2016. Pakan yang diujikan yaitu ikan rucah, abalon (Haliotis glabra) dan cumi-cumi (Loligo pealei). Setelah ditemukan pakan yang paling disukai, kemudian dilakukan pengujian dosis pakan pilihan dengan dosis 10%, 20% dan 30% dari berat bobot ikan. Sampel ikan yang digunakan memiliki rerata panjang 3 cm dan berat 0,47 g sebanyak 45 ekor. Akuarium yang digunakan berukuran 95 cm x 45 cm x 35 cm. Pemberian pakan dilakukan tiga kali sehari. Hasil penelitian menunjukkan bahwa pakan abalon lebih disukai dibandingkan dengan kedua pakan lainnya dengan konsumsi sebesar 0,11 g/ekor per hari. Hasil pengujian dosis pakan abalon menunjukkan pertumbuhan tertinggi dihasilkan pada dosis perlakuan 30% yaitu panjang 2,07 cm dan berat 0,34 g dan dosis 20% yang menghasilkan panjang 2,07 cm dan berat 0,33 g. Hasil uji statistik (LSD) menunjukkan perlakuan dosis 30% dan 20% tidak berbeda nyata (P>0,05). Berdasarkan penelitian ini dapat disimpulkan bahwa abalon adalah pakan alami yang disukai untuk mendukung pemeliharaan ikan capungan banggai dengan pemberian dosis optimal sebesar 20% dari berat bobot sampel per hari.

Kata Kunci :   Ikan capungan banggai, Pakan alami, Lini Aquacultur Training Center.