bluuebunny/crossref_metadata_2025 huggingface dataset:
Gaziantep Mebusu Ali Cenani Bey in Türkiye nin Ekonomik Ve Sosyal Durumuna Dair Değerlendirme Raporu (1930-1931)
Authors: AFŞAR Erkan
Published: March 2022

Erken Cumhuriyet döneminde siyasal, ekonomik, sosyal ve kültürel alanda yapılan yapısal reformların toplum kesimleri üzerindeki etkileri farklı olmuştu. Kimi kesimler bu reformları benimserken kimileri de benimsememişlerdi. Bunun yanı sıra 1929 Büyük Dünya Buhranı’nın ve Serbest Cumhuriyet Fırkası denemesinin farklı kesimler üzerindeki olumsuz etkileri 1930’larda toplumsal gerilimin iyice artmasına ve İsmet İnönü hükümetine tepkiye neden olmuştur. Ülke genelindeki toplumsal muhalefetin ve memnuniyetsizliğin boyutunu yerinde görmek amacıyla Mustafa Kemal Paşa ve yanındaki uzman heyet 17 Kasım 1930-6 Ocak 1931 tarihlerini kapsayan yurt gezisine çıkmışlardır. Çalışmanın konusunu da oluşturan erken Cumhuriyet döneminde Ticaret Bakanlığı yapan Gaziantep Mebusu Ali Cenani Bey bu geziden hareketle yurt gezisi sonrası farklı bakanlık uzmanlarınca hazırlanan notları analiz ederek ülkenin içinde bulunduğu durumla ilgili birçok konuda detaylı bir rapor hazırlamıştır. Raporda ağırlıklı olarak iktisadi ve mali konulara değinilmiş bunun yanı sıra adliye, eğitim ve sağlık gibi konulara da yer verilmiştir. Bunun yanı sıra rapor halkın hangi konularda hükümetten istek ve şikâyetlerinin olduklarını göstermesi açısından da dikkate değerdi. Bu konularla ilgili eksiklikler ve tedbirler belirtilerek devletin güçlenmesi ve toplumsal huzurun sağlanması için hükümete öneriler sunulmuştur. Ayrıca bu konularla ilgili bilgilere ve gözlemlere yer verilmesi o dönemdeki toplumsal iklimi ve durumu anlamak açısından da değerliydi.
Effectiveness of fluoride varnishes on oral health: A systematic review
Authors: Fatima Ezzahra Zidane  , Rachid Fawzi
Published: March 2022

Background: Professionally topical fluoride such as fluoride varnish was approved for preventing and remineralizing dental caries in primary and permanent dentitions. As such, fluoride varnish occupies a privileged place since it is the only topical fluoride for professional use applicable for children under 6 years of age, due to its simplicity, speed, rapidity and safety of use. The aim of this study was to investigate the efficacy of professional fluoride varnish in preventing and managing dental caries in primary teeth. Method: A systematic search of publications from 2013 to 2020 was conducted using 3 databases: PubMed, Cochrane Library and Web of Science. The key words used were “fluoride varnish, children, prevention, remineralization and early childhood caries”. Reviews, non-English articles, and irrelevant studies were excluded. Results: in this article, a total of 08 reports were retained: 4 systematic reviews and 4 trials were included in this review. Three reports investigated the preventive effect on primary teeth using fluoride varnish: 2 comparing fluoride varnish with no treatment and 1 comparing fluoride varnish with standard health program. Two trials investigated the managing effect of dental caries on primary teeth comparing fluoride varnish with standard health program. 1 review reported an arresting effect on dentine caries using silver diamine fluoride. 4 Meta-analysis were performed using 5% Sodium fluoride varnish, to prevent and manage caries, and the preventive fraction ranged from 23% to 70%; highest percentage of 69.9% preventive fraction was observed. Conclusion: The effectiveness of fluoride varnish for the prevention of dental caries was proved, however it depended on the individual caries risk, the area of living of the child and if it is used in complement with a standard health program. On the other hand, the effectiveness of fluoride varnish for the management of dental caries depended on the localization of dental caries.
強制檢疫隔離與人身自由之保障──以提審救濟為中心
Authors: 陳運財 陳運財
Published: March 2022

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Grid-Connected PV System Statistics and Evaluation; Review
Authors: Mosaad Mohamed I.
Published: March 2022

Today, the grid-connected photovoltaic (PV) power system plays a significant role in generating electrical energy by making use of the sun’s rays, then converting it into usable electrical energy and connecting it to the electrical grid. This process can be done by connecting the PV panel to the DC/DC converter then there will be a controlled DC/AC inverter. This paper discusses a literature review about the PV system, types, advantages, and disadvantages, generating level ratings and levels, statistics, and comparisons between countries worldwide. In addition, a review of the control method presented in PV systems.
INVESTIGATION OF NOISE EXPOSURES, PERCEPTION, AND HEALTH EFFECTS IN DIFFERENT MICROENVIRONMENTS IN A UNIVERSITY COMMUNITY
Authors: Amoatey Patrick , Al-Harthy Issa , Al-Jabri Khalifa , Al-Mamun Abdullah , Baawain Mahad
Published: March 2022

This study aims to assess noise levels in selected outdoor and indoor microenvironments in a University community in Oman. The perception of noise levels within the Sultan Qaboos University campus was investigated through a survey study. Also, the effect of exposed noise levels on annoyance and sleep disturbance were predicted including their potential risk on cardiovascular health. Among all the measured parameters, it was found that outdoor (41.6%-50%) and indoor (38.5%-46.2%) microenvironments have exceeded the critical levels of 55 dB during morning and afternoon periods. The respondents (698 people) identified traffic and indoor building-related activities as the main sources of noise levels but the majority (44%) of them rated their impact as low. However, more than 30% of the respondents considered traffic as the main contributor to University noise levels. The percentage of highly annoyed persons was predicted to be high in outdoor areas especially in the residential (25%) and near the hospital (13%) areas. However, indoor environments including construction materials and structures labs (14%) showed similar annoyance rates. Also, the percentage of high sleep disturbed persons was found higher in residential areas (7.4%) areas compared to hospital areas (5.3%) locations. The study concluded that there might be an association between the exposed noise levels and the risk of developing cardiovascular diseases. This is the first study that has provided a high spatial variability noise exposure levels across a University environment in Oman, this will contribute to designing future sustainable mitigation strategies to improve the health and well-being of the exposed population. The study has provided a baseline knowledge needed for future epidemiological studies.
A TIDAL FLOW MODEL OF THE WESTERN COAST OF LIBYA
Authors: Etri Talal , Abugdera Ahmed F. , Elata Abdelrahman
Published: March 2022

This paper presents the hydrodynamics on the western coast of Libya. The investigated area, which is a part of the Mediterranean Sea, is one of the most critical and active coastal region in the country. A 2Dh process-based model for flow based on the Delft3D modelling system from Deltares is constructed for the study area. Extensive field data concerning the tidal constituents were used. The flow model that is necessary to understand the hydrodynamics of the area was calibrated and validated using the field measurements. In this paper, only the water levels and tidal components for the astronomical tide are presented. Calibration and validation of the numerical flow model show that the results of the water level represent the field conditions well. The present study gives insight into the basic hydrodynamic processes of the investigated area. It should help designers and the decision-makers maintain the region for any other economic and social activities. The flow model for the investigated area can be also coupled with any other models like wave, sediment transport, morphodynamic and water quality.
Synthesis, characterization and antimicrobial activity of selenium nanoparticles with Clitoria ternatea on oral pathogens
Authors: Barma Manali Deb , Doraikanan Srisakthi
Published: March 2022

Background: Selenium nanoparticles have been studied for possible therapeutic effects in a variety of oxidative stress and inflammation-mediated diseases such as arthritis, cancer, diabetes, nephropathy, as well as antimicrobial properties. Clitoria ternatea is a perennial herbaceous plant which has been documented for its antimicrobial properties that are beneficial to human health. Therefore, this study was designed to synthesize, characterize and investigate the synergistic antimicrobial activity of selenium nanoparticles with Clitoria ternatea on oral pathogens. Materials and method: Green synthesis of selenium nanoparticles was achieved by a simple biological procedure using the reducing power of Clitoria ternatea flower extract. The synthesized nanoparticles were characterized using UV-vis-spectroscopy and Transmission Electron Microscopy. The antimicrobial activity was assessed using agar well diffusion method against strains of S.aureus, S.mutans, E.faecalis and C.albicans. Results: The synthesised nanoparticles showed potential antimicrobial activity against strains of gram positive bacteria especially against S.aureus where 35 mm of inhibitory activity was observed. They also showed enhanced antifungal property as compared to the control.
Facial types and morphology
Authors: Ese Anibor , Okiemute Etetafia Mabel , Peace Isho , Charity Onuegbu
Published: March 2022

Information on an individual’s facial morphology can have several important clinical and forensic applications. Such information can help to improve or reduce the need for extensive surgical interventions for craniofacial anomalies and trauma. This study scrutinized different facial types and morphology among the indigenes of Ika ethnic group in Nigeria, by means of facial height, facial breath and facial index. The study adopted a cross sectional study design, and was conducted with 384 subjects from Agbor community in Delta State, Nigeria. Data was collected with the aid of a digital sliding caliper, data collection sheet, and pencil. All required measurements were taken with each subject seated on a chair in a relaxed mood and with the head in the anatomical position. Majority of the subjects 125 (32.6%) were in the 21-25years age set. The predominant facial type observed is the hyperleptoproscopic sort as seen in 148 (38.5%). Chi-square test of association between gender and facial type disclosed a significant relationship (p=0.001). Chi-square test of association between age and facial type divulged a remarkable correlation (p=0.015). This study confirmed that majority of the Ika populace have the hyperleptoproscopic facial type.
Factor effecting the sustainable income generation of the value added products of local fishery in Ranong Province, Thailand
Authors: Pranee Supattra , Pungnirund Bundit , Sawasdiruk Jiraphorn , Pulphon Sodsri , Piyamputra Panvipa
Published: March 2022

The study objective was to check the impact of personal characteristics, financial constraints and fish processing methods on the sustainable income generation of the value added products of local fishery in Ranong Province, Thailand. For this purpose, the data was collected from 80 fishermen from the Ranong province of Thailand which was analyzed from both of the statistics of descriptive and inferential. The key findings had shown that majority of the people 70 percent used traditional kiln for the processing of their fishes whereas 24 percent were using the fried fishes within the vegetable oil. It was also found that most of respondents were sourced their credits from their personal savings 46 percent, cooperatives 29 percent and from family and friends was 18 percent for the processing the fish activities and 7 percent from micro finance banks. The respondents had generated their income (gross profit) of THB 2247.80 from roasted fish, THB 1123.90 from dried fish, and THB1669.79 from fried fish. The regression model results had shown that respondent’s personal characteristics, constraints and processing methods had greater influence on the sustainable income generations.
Foundation economic development for network development community tourism by linking local products and cultural capital Samut Songkhram Province
Authors: Chantakit Panyada , Rodjam Chumpon , Saranontawat Kanpetch , Sukmaitree Jagraval , Arsingsamanan Praiya
Published: March 2022

The development of a foundation for economics and business networks plays a significant role in community tourism by linking local products and cultural capital in Samut Songkhram province. Both the foundation for economics and business networks have different objectives however both factors play a vital role in community tourism. Hence the core objective of the present study is to determine the effects of foundation for economics and business networks on local products, cultural capital, and community tourism. To achieve the objective of the present study, a survey was preferred to collect primary data from the respondents that were tourists staying in Samut Songkhram. Consequently, a survey questionnaire was preferred to collect the data. Moreover, Partial Least Square, statistical software was used to analyze the data. Results of the present study revealed that economic foundation, business network, local products, and cultural capital have a significant effect on community tourism. According to the results, the increased value of economic foundation and business network also increases the value of local products, cultural capital, and community tourism. The present study is most important for tourists and practitioners to boost community tourism.
E-Learning for family medicine specialty training
Authors: Alanazi Mansuor A.
Published: March 2022

Since the COVID-19 outbreak, many learning institutions across the world have adopted e-learning programs. It has enabled students to continue with school at home as per the health protocols that restrict contacts and other physical relations. This aims to investigate the factors that influence the choice to implement, use, and sustain an effective eLearning program. Some of the factors investigated were the accessibility of resources, the collaboration of the students, technology, environmental and social factors, ease of using the internet, students computing abilities and costs as factors affecting eLearning. The research method used was qualitative, using a sample of 307 and an online survey to identify and investigate the factors being investigated, and analysis was done using SEM. Using Fornell–Larcker discriminant validity and Heterotrait–Monotrait correlation matrix, the data collected from the sample were analyzed, and results were represented in tables. The results of the study were that the factors that influence the use, implementation and sustainability of e-learning program for family medicine specialty training are; accessibility of resources, a collaboration of the students, technology, environmental and social factors, ease of using the internet, students computing abilities and costs.
The influence of student teams achievement division learning method toward the accuracy of partograph documentation on students in diploma study program of midwifery
Authors: Bau Wawa Amalia , Ahmad Mardiana , Hafsa Amir Mahmud , Usman Andi Nilawati , Djafar Nurhaedar , Nontji Werna
Published: March 2022

Background:The essential aspect ofthe learning system is implementingthe learning method; withthe proper method, the teaching and learning process will be more precise, effective, and efficient. Whereas the dissociated and uncreative learning methods will contribute to the low comprehension material on students. Virtually, various methods can be implemented to escalate students' comprehension in the teaching and learning process; one of those methods is the STAD (Student Teams Achievement Division),which focuses on active learning patterns through Student-Centered Learning. This method teaches students about collaboration, responsibility, interaction, trust, decision making, communication, and conflict management. Objectives:The focal point of this study is to determine the influence of the STAD(Student Teams Achievement Division) learning method on the accuracy ofpartograph documentation. Method:This study uses a Quasi-Experimental design with a Pretest-Posttest Design. The sample in this study consists of 30 students taken fromthe Quota Sampling technique. This study implementsthe Wilcoxon test to analyze the data. Results:The Student Teams Achievement Division learning method significantly influences the accuracy of partograph documentation with a p-value of 0.000 < 0.05. Conclusion:The implementation of the Student Teams Achievement Division learning method can improve student skills in partograph documentation.
Identifying highly vulnerable mosquito breeding sites using machine learning and drone based aerial survey
Authors: Sundhar Shyam V. , Selvan Indhiya V. N , Prasad S. Sanjeevi , Hariharan S. , Agarwal Rashi
Published: March 2022

This study deals with Drone based Aerial Survey in analyzing and identification of highly vulnerable mosquito breeding sites at Buckingham canal Chepauk, Chennai. It is small section of Buckingham canal studied using the drone for capturing the images and furtherly images were processed for identifying the sites prone to breeding of mosquitos. Approach used here of capturing images and classifying the vulnerable sites, using a machine learning approach in for extracting features using the algorithm and later generating a Support Vector Machine to train and classify the images. Tensorflow object detection algorithm was used to detect the object and also generate the probability level. Tensorflow based supervised classification involves stacking multiple layers of neural network for a classification. Methods like back propagation invoked in the neural networks ensures the classification accuracy are increased. In this algorithm Single shot multi box detector (SSD) has been used which provides fast detection. Single shot multi box detector (SSD) method is based on a feed-forward convolutional network, followed by a non-maximum suppression step to produce final detections. The accuracy constraint of 70% was kept for qualifying as a potential site to negate ambiguities arising due to processing errors.
Demographic analysis & management strategies for treatment resistant depression
Authors: Balasubramanian T. , Cherian Lina Elizabeth , Mumthas A. H , Murshid C. P , Jamal Jisna , Anandhi B. , Rasheed A.R. Abdul , Balan P. , Karthikeyan M.
Published: March 2022

Purpose: A substantial proportion of Major depressive disorder patients do not react properly to antidepressants and are classified as having Treatment Resistant Depression (TRD). This study was undertaken to evaluate the demographic profile and management strategies for TRD in psychiatric department of a tertiary care super-specialty hospital. Methods: In this prospective observational study, a total of 27 subjects diagnosed with TRD were enrolled. Treatment resistant cases in the hospital setting were identified by using Montgomery Asberg Depression Rating Scale (MADRS). We evaluated the demographic profile, major adverse drug reactions and treatment provided for those patients and monitored for improvement of conditions. Results: The demographic profile result shows that females had predominance over males. Furthermore, family history also had a strong correlation with the occurrence of TRD. Sertraline, Venlafaxine and Sodium valproate combination was majorly used in the treatment of TRD patients. Among them, Venlafaxine was used commonly in TRD and the MADRS scores shown improvement in patient condition. Apart from drug therapy ECT when given in combination with antipsychotics were also effective in TRD. The major ADRs shown by TRD patients include weight changes, GI problems and sexual dysfunction.
The Futures of the Past The Evolution of Imaginative Animals
Authors: Zacks Oryan , Ginsburg Simona , Jablonka Eva
Published: March 2022

We discuss the evolution of imagination in vertebrate animals within the framework of an evolutionary-transition approach. We define imaginative consciousness and the cognitive architecture that constitutes it and argue that the evolution of full-fledged imaginative consciousness that
enables planning can be regarded as a major transition in the evolution of cognition. We explore the distribution and scope of a core capacity of imaginative cognition in non-human vertebrates — episodic-like memory (ELM) — by examining its behavioural manifestations as well as
the organization and connectivity of the hippocampus, a central hub of episodic memory processes in vertebrates. Although the data are limited, we conclude that ELM evolved in parallel several times through the enrichment of minimal consciousness capacities, that there is a general correspondence
between enhanced behavioural capacities and the size and complexity of the hippocampus during vertebrate evolution, and that the evolution of prospective, planning-enabling imagination is a major transition in cognition and consciousness.
Concepts and Interrelationships of Awareness, Consciousness, Sentience, and Welfare
Authors: Broom Donald M.
Published: March 2022

Concept definitions applicable to human and non-human animals should be usable for both. Awareness is a state during which concepts of environment, self, and self in relation to environment result from complex brain analysis of sensory stimuli or constructs based on memory. There are several proposed categories of awareness. The widespread usage of the term conscious is 'not unconscious' so a conscious individual is an individual that has the capability to perceive and respond to sensory stimuli. It is confusing and scientifically undesirable if conscious is also used to mean aware. Hence it is proposed that conscious should be used only as above. Fully functioning and adequately developed humans and members of many other animal species are sentient. Sentience means having the capacity, the level of awareness and cognitive ability, necessary to have feelings. The welfare of an individual is its state as regards its attempts to cope with its environment. This includes feelings, which are important coping mechanisms, and health. Since feelings involve awareness, there is overlap between welfare assessment and awareness assessment. Methods for assessing awareness, consciousness, sentience, and welfare and links to morality are briefly discussed.
Integración de las funciones sustantivas de la universidad y relación Universidad-Sociedad-Estado
Authors: Cordón y Cordón Mynor René
Published: March 2022

Uno de los principales desafíos de las universidades públicas en la actualidad, es el de contribuir significativamente a construir una sociedad basada en el conocimiento, que afronte con eficacia y equidad, los grandes problemas de las naciones y de la región, lo que deberá hacerse por medio de la integración de sus funciones sustantivas (Docencia, investigación y Extensión), en el marco de su autonomía, por medio de una efectiva relación con los distintos sectores de la sociedad y el Estado.  

 Las Universidades Públicas siguen siendo para la sociedad instituciones de prestigio, y para conservarlo y fortalecerlo se requiere de una nueva visión, que combine calidad con pertinencia, a fin de responder a las expectativas de la sociedad en la que funcionan y a la que se deben.

 Las Universidades Públicas de Centroamérica deben cumplir, no solo con el rol de producir, conservar, transmitir y transferir conocimiento, sino también servir de gran foro de debate para los grandes problemas nacionales, ser las consultoras de la nación, de la provincia y de los municipios, así como el ámbito en el cual puedan discutirse las conveniencias, las ventajas, lo aconsejable y lo no aconsejable para la toma adecuada de decisiones en forma participativa, privilegiando el diálogo de saberes y trabajando en forma integrada con la comunidad.
Avances de los Objetivos de Desarrollo Sostenible (ODS) en las Universidades: Caso UNAN-Managua
Authors: Castillo Villagra Elizabeth , Pallavicini Campos Maritza
Published: March 2022

Las Universidades tienen una función fundamental en

los Objetivos de Desarrollo Sostenible (ODS), ser el

cimiento necesario para el futuro social y profesional

en el que se consignan las metas para el desarrollo de

las sociedades.

 

 

La UNAN-Managua se ubica en una nueva etapa,

tomando un papel activo, dirigido a la sociedad

nicaragüense y sus comunidades, incidiendo en la

participación de los actores sociales para contribuir y

beneficiar el desarrollo. La universidad ha asumido el

compromiso de los Objetivos de Desarrollo Sostenibles

(ODS) de la Agenda 2030 y los ha integrado en el trabajo

que se realiza desde sus funciones sustantivas, para el

fortalecimiento del vínculo Universidad-Sociedad.

 

 

Para lograr los resultados presentados en este artículo

se utilizó la metodología cuanti-cualitativo, de la

información suministrada de los programas y proyectos

ejecutados por las distintas Unidades Académicas de la

UNAN-Managua, que están dando cumplimiento a los

ODS de la Agenda 2030.

 

Los resultados del estudio realizado en las distintas

Facultades, POLISAL, Institutos, Centros de

Investigación y Laboratorios crean una visión sobre las

áreas de incidencia hacia la sostenibilidad económica,

social y ambiental desde el quehacer institucional en

pos del logro de los ODS de la Agenda 2030 en los

próximos diez años.
Observatorio de Medios Digitales: una conexión entre la academia y los medios
Authors: Rojas Icabalzeta Ruth Nohemí
Published: March 2022

Este ensayo presenta el quehacer del Observatorio deMedios Digitales de Nicaragua en su afán de conectarla academia con los medios de comunicación socialdel país. El objetivo es sistematizar las experienciasmediante las actividades que se han desarrolladoen el marco del observatorio para dar respuestaa las necesidades que enfrentan los periodistas ycomunicadores a nivel nacional. La metodologíamediante la que se construye el texto es el proceso desistematización e interpretación crítica de la experienciadel observatorio, así como la revisión de literaturapara la descripción de algunos datos que conllevan a ladiscusión del tema central. Los principales resultadosde este ensayo sintetizan las diferentes actividadesvinculadas a la labor que desempeña el observatorio através de las que se han obtenido efectos satisfactoriosen pro del fortalecimiento de la formación académicade los periodistas y comunicadores nacionales. Eneste contexto, se tiene confianza en el cumplimientode los propósitos de conectar los conocimientos de laacademia con las necesidades de los periodistas conuna conciencia social hacia el cambio.
The Embodied Meaning of “Disease” in Analects of Confucius and Interpretation of Body-Life Management
Authors: DU Haitao
Published: March 2022

The tension between “body” and “life” has always been the core theme of Chinese philosophy. However, a close reading of Analects of Confucius from the perspective of “disease” reveals a harmony between body and life. Confucius traced the religious attribution of disease from ancient times and advocated the goodness of body and life in the pursuit of a good life, which indicates a non- constructive body view with the presence of the body, and reflects his realistic view on life. In addition, Confucius argued the pursuit of life despite disease should be realized through individual cultivation in ethical life, which suggests the integration of body and life can be achieved through spiritual transcendence over the restrictions of physical disease. Therefore, self-body-life management is of great significance, which reflects the philosophical connection between the ancient theory of self-cultivation and disease. In terms of “social governance” of diseases, though Confucius did not illustrate how “self-cultivation to pacify the common people” could be presented as a kind of social medical construction, he highlighted the sociality of diseases in the humanistic sense, and advocated the special settlement of “peace in disease” in human relations, which can be regarded as the embodiment of ancient ethical social governance of diseases, and is of significance to the construction of medical system today.
Receptores tiroideos de estrógenos y progesterona: ¿Cumplen estos una función en el desarrollo del Cáncer Papilar de Tiroides en los hombres?
Authors: Duque Carlos Simón , Vélez Alejandro , Isaza Adriana , Londoño Andrés , Dueñas Juan Pablo , Zuleta Jhon J , Agudelo Miguel
Published: March 2022

Contexto: el cáncer de tiroides es más común en mujeres que en hombres, es por esto por lo que, pese a que se ha propuestouna teoría de origen de esta tumoración en las hormonas femeninas, esta hipótesis al momento no ha podido ser validada.Objetivo: se propuso un estudio piloto para evaluar la posibilidad de encontrar marcadores hormonales femeninos en tejido de pacientes hombres intervenidos por cáncer de tiroides.Metodología: las muestras de tejido de diez pacientes hombres intervenidos por cáncer papilar fueron sometidas a estudiosde inmunohistoquímica con marcadores para estrógenos y progesterona.Resultados: ninguna de las muestras de tejido de hombres con cáncer papilar sometidas a estudios de inmunohistoquímica en este estudio piloto reaccionó frente al marcador hormonal femenino.Conclusiones: este estudio piloto, de una serie de casos pequeña, no demostró relación hormonal en tejido tiroideo de pacientes hombre con cáncer papilar frente a los marcadores para estrógenos o para progesterona.
Claude Bernard y las claves para un método de hallazgos serendípicos en los descubrimientos científicos
Authors: Mejía Rivera Orlando
Published: March 2022

Propósito: el propósito de la presente investigación es entender el valor epistemológico de la obra de Claude Bernard sobre un contexto actual, donde la serendipia científica permite desprenderse de ideas y teorías que se creían válidas para lograr encontrar respuesta a problemas que no han podido ser resueltos hasta el momento.Contenidos: el contenido explica la vida del autor y describe los hechos que lo llevan al quehacer médico, luego se reflexiona sobre los experimentos más notorios y que permitieron avances en el mundo, tales como, por ejemplo, el descubrimiento dela glucogénesis animal.Contribuciones: este texto es un aporte a los científicos y médicos actuales que buscan nuevas maneras de descifrar ciertosproblemas que todavía no han podido ser resueltos. Los conceptos de serendipia científica, descubrimientos científicos yhallazgos por medio de la experimentación a través de la historia, permiten ser una fuente de inspiración para las nuevasgeneraciones de investigadores.
Psychogenic astasia-abasia: A case of unsteady gait
Authors: Chan Chung Charles , Koh Yeow-Hoay , Tan Eng-King
Published: March 2022

Falls remain common health problems that our elderly population has to face in their daily life, contributing significantly to their morbidity. Patients with astasia-abasia should be recognized promptly though it is uncommon in Singapore. We report a case of a middle-aged lady who presented with psychogenic astasia-abasia. We will illustrate this case with the exhibition of a video showing her gait pre- and post-interventions. Consent was obtained from the patient. Our patient received a multi- disciplinary level of care, including physiotherapy and psycho-education with good response. We performed a non-systematic literature review and we hereby review its description and management.
Akinetic rigid syndrome as a presenting feature of subacute sclerosing pan encephalitis
Authors: Cornelius Leema Pauline , Elango Neeraj , Jeyaram Venkateswaran Kuttava
Published: March 2022

Atypical presentations of subacute sclerosing panencephalitis include hemiparesis, acute disseminated encephalomyelitis, cerebellar ataxia, visual disturbances, symptoms suggestive of the intracranial space- occupying lesion, and extrapyramidal movement disorders. Parkinsonism as the presenting feature of subacute sclerosing panencephalitis is a rare occurrence. Here we report a child who presented with bradykinesia and rigidity, underwent extensive investigations, finally turned out to be subacute sclerosis panencephalitis.
Dysphagia in patients in acute period of ischemic stroke: What is the relationship of dysphagia with infarct localization, cognition, malnutrition, and independence level?
Authors: Parlak Mümüne Merve , Bizpinar Özlem , Saylam Güleser
Published: March 2022

Background and Objective: Swallowing and nutritional disorders can occur for many different reasons after stroke. This study aimed to evaluate dysphagia, malnutrition, and independence in patients with an acute period of ischemic stroke, and to examine the relationship between dysphagia and lesion location, cognition, malnutrition, and dependence.
Methods: Ischemic stroke patients (n: 109, mean age: 72.91 ± 11.78 year) were evaluated within the first 5 days after stroke. Standardized Mini-Mental State Examination (SMMSE), Combining pulse oximetry with a 10 milliliter (ml) Bedside Water Drinking Test (CPOBWDT), Mini Nutritional Assessment (MNA), and Barthel Index (BI) were performed.
Results: Dysphagia was detected in 57.8% of the patients; malnutrition was present in 19.27% and 55.96% were at risk of malnutrition. In patients with dysphagia, it was observed that the most common site of infarct involved the superior cortical division of the middle cerebral artery. SMME (p<0.001) and BI (p=0.001) were significantly worse in patients with dysphagia than patients without dysphagia.
Conclusion: This study showed that more than half of the ischemic stroke patients are at risk of dysphagia and malnutrition in the acute period after stroke. The localization of the infarct and a decrease in the cognitive level are among the factors that are associated with dysphagia. Dysphagia is associated with increased dependence for functional activities. Therefore, in patients with ischemic stroke, swallowing and malnutrition should be evaluated during the acute phase.
Clinical profile of cerebral venous thrombosis in a tertiary care center and utility of D-dimer in its diagnosis
Authors: Colaco K Vimala , Paneyala Shasthara , Sundaramurthy Harsha , S C Nemichandra , Iqbal Roshan
Published: March 2022

Background & Objectives: Cerebral venous thrombosis (CVT) is a rare cause of stroke, occurring commonly in young adults. The variability in the clinical scenario from patient to patient and the lack of specificity of the presenting symptoms of CVT poses a diagnostic challenge. This study aims to analyze the clinical characteristics of patients diagnosed with CVT in comparison to the global profile and explore the diagnostic utility of D-dimer levels as a screening tool in patients with clinical features suspicious of underlying CVT.
Methods: This was a hospital-based case-controlled study, included 50 imaging proven patients with CVT and age and sex matched healthy controls. Demographic details were collected, detailed neurological examination done at presentation and d- dimer levels were evaluated.
Results: Among our study group a male preponderance was noted (60%) in discordance with the global pattern of CVT. Headache was the most common presenting feature and papilledema was noted in 98% of our patients. Additional clinical signs noted at presentation were nausea and vomiting (78%), seizures (28%), limb weakness (24%) and alteration in sensorium at presentation (14%). Risk factors were alcohol dependency (36%), postpartum period (12%) and anaemia (12%). Additionally the sensitivity of D-dimer was noted to be 90.74% with a specificity of 100% in predicting the disease.
Conclusion: Our study differs from the global pattern of CVT in terms of male preponderance, higher detection of papilledema, lesser occurrence of anaemia, and a large proportion of patients with d-dimer positivity. The limitation of the study is the sample size as we cannot extrapolate our results to the population at large. However our data is in concordance with the current concept of CVT, that diagnosis is the key challenge in management.
ATG7 polymorphisms rs7625184 and rs2606750 are not associated with Parkinson’s disease
Authors: Zou Ming , Wang Jian-Yong , Lv Ren-Jun , Nie Shan-Jing , Zhu Lan-Bing , Liu Xue-Ping
Published: March 2022

Background & Objective: Deregulation of autophagy is involved in the development and progression of Parkinson’s disease. ATG7, an E1 like enzyme, plays a key role in autophagy. This study aimed to investigating the association between ATG7 polymorphisms and PD susceptibility.
Methods: Single nucleotide polymorphisms of ATG7, including rs7625184 and rs2606750, were identified by polymerase chain reaction-restriction fragment length polymorphism in a Han Chinese population consisting of 312 PD patients and 309 healthy controls.
Results: Genotyping analyses showed that none of the 2 SNPs was significantly associated with PD risk.
Conclusions: Our results suggest that rs7625184 and rs2606750 are not associated with PD susceptibility. Further studies are warranted to reveal the links between ATG7 and PD.
An ultra-rare cause of severe hypotonia mimicking Pompe disease in an infant: RRM2B related mitochon- drial DNA depletion syndrome with a novel mutation
Authors: İnci Aslı , Okur İlyas , Demir Ercan , Biberoğlu Gürsel , Tümer Leyla , Serdaroğlu Ayşe , Ezgü Fatih Süheyl
Published: March 2022

Ribonucleotide-diphosphate reductase subunit M2B(RRM2B)-related mitochondrial disease is one of the ultra-rare mitochondrial depletion syndromes. A-2-months of age girl who had severe hypotonia with absent reflexes, failure to thrive, and developmental delay was hospitalized under our care. The initial diagnosis was Pompe disease with absent reflexes and increased creatine kinase level. Enzyme analysis for Pompe disease was normal and next-generation sequence panel analysis of 450 genes related to metabolic disorders revealed a novel mutation in the RRM2B gene. The patient died at the age of 2.5 months. Up to date, there have been reports of 31 patients with infantile forms of RRM2B. This patient presented with little features to suggest a mitochondrial disorder. In conclusion, RRM2B mutations should be included in the differential diagnosis of the Pompe disease in infants with severe hypotonia. This case report also expands the mutation spectrum of rare infantile form of the RRM2B mutations.
Traditionally used herbal remedies by the indigenous tribes of Meghalaya: A Review
Authors:   Regional College of Pharmaceutical Sciences, RIPT Group of Institutions, Guwahati-782402, Assam, India, Kalita Tutumoni
Published: March 2022

Meghalaya, one of the seven sisters of North-East India, is bestowed with many plant species of medicinal importance. Herbal remedies have played an integral role in developing the cultural and spiritual life of the indigenous tribes of Meghalaya by assisting the primary healthcare needs of the people. In addition, the knowledge of traditional herbal medicine may serve as the basis for new drug discovery. However, the scientific community's vast ethnomedicinal knowledge of Meghalaya remains unexplored. In the present study, an effort has been made to shed light on the substantial folklore knowledge about various plant species that grow in the region, highlighting the traditional utilization method. A total of 150 medicinal plants belonging to 129 genera and 89 families were documented based on a thorough literature survey involving various research and review articles with an extensive search on PubMed, Google Scholar, Elsevier and other renowned journal sites.
Adoption of Entrepreneurial Behaviours in Sports Tourism in Developing Countries
Authors:   Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, 9177948979, Iran, Heydari Reza , Keshtidar Mohammad ,   Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, 9177948979, Iran, Ramkissoon Haywantee ,   Centre for Contemporary Hospitality & Tourism & Centre for Business Improvement, College of Business, Law & Social Sciences, Derby Business School, University of Derby, Derby, DE22 1GB, UK,   College of Business, Johannesburg Business School, University of Johannesburg, Johannesburg, 2092, South Africa,   Faculty of Social Sciences & Leisure Management Taylor's University, 47500 Subang Jaya, Selangor, Malaysia,   Excelsia School of Business, Sydney, NSW 2113, Australia, Esfahani Mahdi ,   Sports Centre, Imamreza International University, Mashhad, Iran, Asadollahi Ehsan ,   Sanabad Golbahar Higher Education Institute, Golbahar, Iran
Published: March 2022

The aim of this study is to identify the adoption of entrepreneurial behaviours in sports tourism in developing countries. This research is a qualitative study. The systematic method of Strauss and Corbin has been used to analyse the data. Based on the results of in-depth interviews with stakeholders (n = 25), 75 indicators of sports tourism entrepreneurship were identified. Our research findings show that the necessary institutional arrangements in regulatory/legal/administrative dimensions (rule of law, government policies), normative/cultural (social norms, values, and beliefs), cognitive/educational (promotion of elite knowledge, promotion of social knowledge) and guidance measures/supporter (public sector support, private sector support, complementary attraction and information technology) have potential to improve the rate of entrepreneurial behaviours by increasing the ability and willingness of entrepreneurs to take advantage of entrepreneurial opportunities in the field of sports tourism. Our findings suggest that co-actors need to engage in a multi-stakeholder engagement approach to promote the tourism sports industry in developing countries. The existence of a legal, normative, supportive and educational environment may influence the ability and desire of market participants to identify and embrace entrepreneurial opportunities in the sports tourism sector.
Identification, Characterization, and Efficacy Evaluation of Bacillus velezensis for Shot-Hole Disease Biocontrol in Flowering Cherry
Authors: Han Viet-Cuong , Yu Nan Hee , Yoon Hyeokjun , Ahn Neung-Ho , Son Youn Kyoung , Lee Byoung-Hee , Kim Jin-Cheol
Published: March 2022

Though information exists regarding the pathogenesis of the shot-hole disease (SH) in flowering cherry (FC), there has been a lack of research focusing on SH management. Therefore, here, we investigated the inhibitory activities of antagonistic bacteria against SH pathogens both in vitro and in vivo as well as their biochemical characteristics and bioactive compounds. Two biosurfactant-producing bacterial antagonists, identified as Bacillus velezensis strains JCK-1618 and JCK-1696, exhibited the best effects against the growth of both bacterial and fungal SH pathogens in vitro through their cell-free culture filtrates (CFCFs). These two strains also strongly inhibited the growth of the pathogens via the action of their antimicrobial diffusible compounds and antimicrobial volatile organic compounds (VOCs). Crude enzymes, solvent extracts, and biosurfactants of the two strains exhibited antimicrobial activities. Liquid chromatography/electrospray ionization time-of-flight mass spectrometric analysis of the partially purified active fractions revealed that the two antagonists produced three cyclic lipopeptides, including iturin A, fengycin A, and surfactin, and a polyketide, oxydifficidin. In a detached leaf assay, pre-treatment and co-treatment of FC leaves with the CFCFs led to a large reduction in the severity of the leaf spots caused by Epicoccum tobaicum and Bukholderia contaminans, respectively. In addition, the two antagonists produced indole-3-acetic acid, siderophore, and a series of hydrolytic enzymes, along with the formation of a substantial biofilm. To our knowledge, this is the first report of the antimicrobial activities of the diffusible compounds and VOCs of B. velezensis against the SH pathogens and their efficiency in the biocontrol of SH.
A thermal forecasting model for the overwintering generation of cotton bollworm by remote sensing in the southeast of Caspian Sea
Authors: Jokar Mahmoud
Published: March 2022

Aim of study: Cotton bollworm (Helicoverpa armigera) is a key pest of cotton all around the world. The Degree-Day (DD) model, as a reliable forecasting approach, is based on the cumulatively effective temperature which must be received by the pests to complete their life cycle. The main objective of the current research was the feasibility of using two accessible thermal data to predict the emergence time of the first generation of H. armigera.
Area of study: Golestan province of Iran
Material and methods: The lower temperature threshold (T0) and the thermal constant (k) were calculated by separately incubating batches of 10 pupae (≥24 h) at a wide range of temperatures (20, 25, 30, 35, and 40 ) in laboratory conditions. The thermal requirements of the overwintering generation were estimated via two types of thermal data sources, i.e., Land Surface Temperature (LST) of Terra® satellite and synoptic meteorological stations from January 21st, 2020 to the end of May 2020.
Main results: T0 and k of the pupal stage were found to be 9.75±1.41°C and 250.57±4.66 (DD), respectively, via the linear regression and 10.26±1.09°C and 240.85±6.71 (DD) through Ikemoto & Takai’s model. The time series of satellite thermal data (LST-day and LST-night) modified through laboratory DD parameters was validly identified to determine high-risk areas and predict the emergence times of the first generation of cotton bollworm. This was in agreement with the reports of the governmental Plant Protection Organization.
Research highlights: If there is a lack of meteorological synoptic stations in some agricultural areas, the LST data of Terra® satellite could be replaced by the meteorological data for DD forecasting models.
Pengaruh Pembelajaran Online Kontekstual dengan Video Praktik Terhadap Pemahaman Materi Pengukuran bagi Peserta Didik
Authors: Febriana Maghfira , Sasmita Harya Fitra Sahal
Published: March 2022

This study aims to determine the effect of applying contextual model online learning with practice videos on the understanding of the material for measuring Physics subjects for 10th grade MIPA at SMA Kesatrian 2 Semarang. The data was taken based on the results of the students' pretest and posttest and then analyzed using Wilcoxon non-parametric statistics. The hypothesis given is Ha: there is a difference in the results of the pretest and posttest, and Ho: there is no difference in the results of the pretest and posttest. Based on the SPSS calculation results show the value of asymp.sig. (2-tailed) = 0.000 with a significance level of 5% (0.05) because the value of 0.000 is smaller than 0.05, it is concluded that "Ha is accepted". This means that there is a difference between the results of the pretest and posttest, so it can be concluded that there is an effect of implementing contextual online learning with practice videos on the understanding of the measurement material for students.
Etos Kerja Perspektif Al-Qur’an dan Hadis
Authors: Khairullah Khairullah , Taufiqurrahim Aziz , Rohman Eko Nur , Rahmawati Dhiah , Mufid Abdul
Published: March 2022

The Qur'an and Hadith are Islamic teachings in which there are teachings for charity and work which are prescribed in the sentence "amal as shalihat". The work ethic is one of the seven elements of universal culture, namely the element of "living livelihood system". livelihood system means economic life. Work is an activity carried out by humans in achieving prosperity and if they are lazy, they will fail to get it. Success and failure are the result of their own hard work efforts. In Islam, the characteristics of the work ethic are looking for worldly wealth in a lawful way, not asking for help, providing for family needs and compassion for neighbors. As Rasulullah saw., made work as the actualization of faith and piety. Therefore for a Muslim life is to work. Allah SWT in his word remember that Allah SWT will not change the fate of humans before humans change what is in themselves.