bluuebunny/crossref_metadata_2025 huggingface dataset:
Kurzarbeit – für welche Zwecke die Beschäftigten die zusätzliche disponible Zeit verwenden
Authors: Pusch Toralf , Seifert Hartmut
Published: November 2022

Der Beitrag zeigt auf Basis der Erwerbspersonenbefragung der Hans-Böckler-Stiftung, für welche Zwecke Kurzarbeitende während der Pandemie die gewonnenen Zeitelemente verwendet haben. Bisherige Arbeiten fokussieren sich lediglich auf einzelne Arten der Zeitverwendung, so auf Sorgearbeit oder Weiterbildung. Demgegenüber erlauben die verwendeten Daten, den Blick auf ein breiteres Spektrum von Zeitverwendungen auszuweiten und Zeitmuster aufzuzeigen. Bei den dargestellten Ergebnissen für die Zeitverwendung in der Kurzarbeit ist zu beachten, dass diese als unfreiwillige Arbeitszeitverkürzung mit Teillohnausgleich nicht Ergebnis individueller Wahlentscheidungen sind. Kurzarbeit ist temporär, häufig mit ungewisser und teilweise unterbrochener Dauer. Die empirischen Analysen zeigen, dass die durch Kurzarbeit vermehrt verfügbare Zeit vor allem für Aktivitäten im Haushalt, Familie, Medienkonsum und Kinderbetreuung genutzt wurde. Dagegen überwiegt die Zahl der Kurzarbeitenden, die bei Hobby / ​Sport sowie politischem und gewerkschaftlichem Engagement ihren Zeitaufwand reduziert haben, diejenigen mit erhöhtem Zeiteinsatz. Für Frauen gilt dieses Muster im Vergleich zu Männern etwas ausgeprägter, aber auch Männer haben ihren Zeiteinsatz im häuslich-familiären Bereich gesteigert.
The EPPO‘s Material Competence and the Misconception of „inextricably linked offences”
Authors: Neumann Laura
Published: November 2022

The first year of operations of the European Public Prosecutor’s Office (EPPO) was basically very successful. However, also several problems came to light which the European Union’s first original prosecution authority has still to overcome. One of the most fundamental of these problems is the EPPO’s material competence for offences only “inextricably linked” to offences against the Union’s financial interests for which the EPPO shall, in principle, only be competent at present according to the Treaties. This article examines the concept of “inextricably linked offences” as it is enshrined in Regulation (EU) No. 2017/1939 today. In their current shape, the relating provisions are revealed to be highly problematic as they bear the potential to severely restrict the EPPO’s effectiveness. Therefore, the article proposes possible alternative designs as an incentive for a revision of the current guidelines and rules on the EPPO.
The Offences of Slavery, Servitude, Forced Labour and Labour Exploitation: A Comparative Study (Part II)
Authors: Cucinotta Carlo
Published: November 2022

In the absence of unambiguous interpretations of the concepts of slavery, servitude, forced labour and labour exploitation offered by the sociological and anthropological debate, the article analyses the same concepts from a normative point of view, first considering the approach of the European Court of Human Rights and then examining the solutions adopted by the Italian, French, German and Spanish criminal codes. The comparative investigation reveals significant similarities but also common problems in national legislations, which call for intervention by the European Union legislature.
Vor und nach dem Entwicklungsdienst: Das Engagement von (rückkehrenden) Fachkräften
Authors: Waibel Gabi , Gaisbauer Felix , Schwedersky Thomas
Published: November 2022

Rund 32.000 Fachkräfte leisteten einen Entwicklungsdienst im Globalen Süden. Obwohl dies nach dem Entwicklungshelfer-Gesetz „ohne Erwerbsabsicht“ stattfindet, wurde bislang nicht untersucht, inwiefern sich eine solche Tätigkeit und Engagement wechselseitig bedingen. Dieser Beitrag untersucht zwei Forschungsfragen: (1) Inwieweit ist Engagement-Bereitschaft ausschlaggebend für die Aufnahme eines Entwicklungsdienstes? (2) Inwieweit sind Fachkräfte vor und nach dem Entwicklungsdienst engagiert und wie verändert sich das Engagement durch den Dienst? Auf Basis einer quantitativen Studie lässt sich festhalten, dass (i) Engagement-Bereitschaft die entscheidende Motivation für den Entwicklungsdienst darstellt, (ii) die meisten Fachkräfte bereits vor ihrem Entwicklungsdienst engagiert waren, und (iii) der Entwicklungsdienst vor allem durch eine Vertiefung der Engagement-Bereitschaft und Verbreiterung von Engagement-Formen qualitativ nachwirkt. Diese Befunde werden vor dem Forschungsstand zu internationalen Freiwilligendiensten diskutiert.
Pituitary Adenomas: Classification, Clinical Evaluation and Management
Authors: Ibrahim Bilal , Mandel Mauricio , Ali Assad , Najera Edinson , Obrzut Michal , Adada Badih , Borghei-Razavi Hamid
Published: November 2022

Pituitary adenomas are one of the most common brain tumors. They represent approximately 18% of all intracranial, and around 95% of sellar neoplasms. In recent years, our understanding of the pathophysiology and the behavior of these lesions has led to better control and higher curative rates. The treatment decision is largely dependent on type of the adenoma, clinical presentation, and the size of the lesion. In addition, incidental pituitary lesions add uncertainty in the decision-making process, especially for pituitary adenomas that can be medically managed. When surgery is indicated, the endoscopic endonasal transsphenoidal approach is the technique of choice, but open standard craniotomy approaches can also be the option in selected cases. The following chapter will review the classification, clinical presentation, pathophysiology, diagnostic work-up, selection of surgical approach, and treatment complications in pituitary adenomas.
Safety of Food throughout the Supply Chain
Authors: Karimi Fraidoon
Published: November 2022

Today, in addition to food security, food safety is very important, because one of the prominent causes of increasing diseases is changing people’s eating habits and lack of food safety along the food chain. Vegetables and fruits, in all stages of the food supply chain, are contaminated with a variety of bacteria, viruses, protozoa, and parasites. The prevalence of many diseases has been recorded in the past as a result of eating fruits and vegetables. The results of extensive research conducted in this field around the world were used in this chapter, and melon is discussed in detail as an example. Research findings show that pathogens that lodge in the skin of melon can enter the melon flesh when cut and infect it. Similarly, in hot climates, the bacteria Salmonella, Listeria, and E. coli multiply easily in melon flesh at low pH and soon reach pathogenic doses. Therefore, appropriate hygiene measures should be considered along the food chain. These hygiene measures are considered very important from the perspective that very small contamination by campylobacter, Escherichia coli, and norovirus, for example, can cause a major health problem. Highly vulnerable people include pregnant women, young children, the elderly, and the sick.
Penyuluhan Manfaat Multivitamin untuk Imunitas Tubuh di Masa Pancaroba
Authors: Endriyatno Nur Cholis , Ningrum Dian Ayu , Hafidzah Eni , Ramadani Noveria Riski , Cahyaningtiyas Nur , Widiawati Rahma
Published: November 2022

The immune system is an essential thing and needs to be maintained, this is done so that the body's immune system remains in a strong and optimal condition. A body with a good and strong immune system is very important and has a vital role in the body's defense, especially in terms of preventing various diseases, especially infectious ones, especially during the transition season. Some of the people in the Pandanarum Tirto sub-district are known to be less concerned about health, especially in maintaining their immune system. From this background, educational activities were carried out to increase public understanding in the blood about the importance of the role of multivitamins in the transition season. Education is carried out by delivering material and question and answer discussions. This community service activity is in the form of counseling with the aim of helping the community to change their lifestyle/behavior and be aware of the importance of consuming multivitamins for immunity in the transition season. With this activity, it is hoped that the public can understand the importance of taking multivitamins in the transition season and can also find out information on how to use multivitamins properly and appropriately to obtain and maximize therapy. The conclusion of this service activity is that the community becomes more aware, understands, and is interested in the importance of the benefits of multivitamins for body immunity in the transition season.
Pelatihan Bagi Pengrajin Genteng Tradisional Desa Sidorejo Kecamatan Godean Kabupaten Sleman DIY
Authors: Hasbi  , Elviana  , Setialana Pradana
Published: November 2022

Saat ini sistem produksi genteng yang dilakukan UKM Sokka SBD tergolong masih sangat sederhana, khususnya pada proses pengangkutan genteng setelah dicetak dan saat penjemuran. Pada proses pencetakan, selain mencetak genteng pengrajin juga harus memindahkan genteng yang telah dicetak menuju tempat penyimpanan yang ditata di rak penyimpanan genteng. Pemindahan genteng dilakukan dengan membawa genteng satu per satu setelah genteng di cetak di mesin pres yang di operasikan secara manual. Selain itu, mitra juga belum memiliki kemampuan penggunaan teknologi informasi sebagai media pemasaran untuk memperluas jaringan. Sistem pemasaran mitra sangat bergantung pada pesanan dari tetangga, kerabat dan informasi dari mulut kemulut. Solusi yang ditawarkan adalah dengan membuat alat bantu produksi genteng Manual Material Handling (MMH) berupa rak multipurpose, website dan pemasaran menggunakan social media. Dalam pelaksanaan kegiatan pelatihan yang dilaksanakan, peserta diberikan penguatan tentang bagaimana cara mengatasi pemasalahan yang dialami mitra selama ini dengan penerapan Manual Material Handling (MMH) berupa rak multipurpose, website dan pemasaran menggunakan social media. Hasil dari kegiatan tersebut diperoleh bahwa kegiatan yang sudah dilakukan dapat menambah wawasan pengetahuan peserta dalam hal ini pengrajin genteng yang ada di Kecamatan Godean, kegiatan ini dapat membantu para pengrajin genteng di Kecamatan Godean dalam menggunakan alat bantu berupa Manual Material Handling (MMH), website, dan social media  dalam penggunaan dan penerapan dalam melakukan proses produksi dan penjualan genteng.
Pemberdayaan Masyarakat Desa Melalui Budidaya Sayuran Hidroponik Wick System Dilahan Pekarangan Desa Triwikaton
Authors: Novianto Novianto , Dwiana Syndy
Published: November 2022

Pemberdayaan masyarakat dilakukan melalui penyuluhan untuk meningkatkan pengetahuan dan teknologi masyarakat terutama di bidang pertanian untuk menjaga ketahanan pangan rumah tangga melalui budidaya tanaman secara hidroponik. Tujuan dari kegiatan Pengabdian Kepada Masyarakat untuk mengembangkan melalui penerapan teknologi budidaya sayuran wick system hidroponik dengan teknik pemberdayaan masyarakat desa.  metode yang digunakan dalam kegiatan ini  yaitu metode observasi dan survey serta demonstrasi ke lokasi. Kegiatan pngabdian ini dapat disimpulkan adanya respon positif dari peserta dalam mengadopsi pengetahuan dan teknologi sehingga dapat membantu menambah ilmu pengetahuan dan teknologi yang selama ini dari tidak tahu menjadi tahu dalam pemanfaatan lahan perkarangan dan menggunakan teknologi hidroponik secara sederhana, untuk memenuhi kebutuhan rumah tangga dan pendapatan masyarakat.
Pemanfaatan Media Sosial Dalam Mengembangkan Intelegensi Anak Di Era Milenial Melalui Kegiatan Interaktif Pada Yayasan Panti Asuhan Al-Imran Kabupaten Gowa
Authors: Retyana Wahrini  , Faisal Najamuddin
Published: November 2022

Program Pengabdian kepada Masyarakat (PkM) ini berjudul Pemanfaatan Media Sosial Dalam Mengembangkan Intelegensi Anak Di Era Milenial Melalui Kegiatan Interaktif Pada Yayasan Panti Asuhan Al-Imran  Kabupaten Gowa . Media sosial merupakan hal yang sangat penting bagi kehidupan manusia. Dengan perkembangan zaman hal ini akan mempengaruhi perilaku dan kehidupan manusia masa kini. Maka dengan adanya perkembangan teknologi manusia harus bisa menyikapi dan menelaah mana perkembangan media sosial yang baik dan mana yang buruk Lembaga Kesejahteraan Sosial Anak (LKSA) di Kabupaten Gowa diwujudkan dalam bentuk panti asuhan sebagai penyelenggara program kesejahteraan sosial anak.  UNM sebagai salah satu perguruan tinggi besar di Indonesia Timur melalui Lembaga Penelitian dan Pengabdian kepada Masyarakat (LP2M) setiap tahunnya menawarkan kegiatan penelitian dan pengabdian melalui program PNBP. Melalui program tersebut kami bermaksud untuk membuat sebuah kegiatan berupa pengarahan terkait Pemanfaatan Media Sosial dalam Mengembangkan Intelegensi Anak di Era Milenial Melalui Kegiatan Interaktif yang Positif Pada Yayasan Panti Asuhan Al-Imran Kabupaten Gowa. Berdasarkan hasil observasi tim PKM yaitu dengan menggali informasi terkait kebutuhan dan permasalahan mitra terutama pada anak-anak Yayasan Panti Asuhan Al-Imran Kabupaten Gowa, maka kami dapat mendeskripsikan secara rinci pokok permasalahan yang dimilikinya. Diantaranya adalah anak anak yang tinggal di Panti Asuhan Al Imran terlihat belum dapat menyikapi dan menelaah mana perkembangan media sosial yang baik dan mana yang buruk, Belum optimalnya pemberian pengetahuan dalam penggunaan Media Sosial untuk anak anak di Panti Asuhan Al Imran Kabupaten Gowa, dan terdapat puluhan anak yang menggunakan media sosial secara berlebihan. Seperti saat bermain gameonline, browsing, dan membuka jejaring sosial, anak di daerah ini terfokus pada media sosial yang ditekuninya. Sehingga anak tersebut tidak memperhatikan sekelilingnya dengan baik dan acuh tak acuh pada orang di sekitarnya
Narrativas transmedia en bibliotecas
Authors: Cabral Rubén Gonzalo
Published: November 2022

El presente documento, reviste en carácter de ensayo, la presentación de una experiencia de narrativa transmedia desarrollada en el club de lectura virtual de la carrera de Bibliotecología –a distancia- dependiente de la Pontificia Universidad Católica Argentina.

La posibilidad de contar historias y relatos a través de distintos medios, es para las bibliotecas la oportunidad de fidelizar usuarios y promover la lectura, utilizando las tecnologías de la información y la comunicación como espacio de encuentro. Estos servicios innovadores para las unidades de información, constituyen excelentes formatos para promover espacios de sociabilidades de lectura.
La adopción del campus virtual a la enseñanza presencial de bibliotecología: la experiencia el Departamento de Bibliotecología de la Universidad Nacional de La Plata (Argentina).
Authors: Corda María Cecilia , Medina María Celeste
Published: November 2022

Se analiza el uso del campus virtual, que emplea el software libre Moodle, por parte de las y los docentes de la carrera de bibliotecología de la Facultad de Humanidades y Ciencias de la Educación de la Universidad Nacional de La Plata, Argentina. Dicho campus se instrumentó a partir de los años 2006-2007 como apoyo a la enseñanza presencial de la disciplina. En el presente trabajo, se aplica una encuesta en línea a las profesoras y los profesores, constituida por preguntas cerradas y una abierta. A través de ella se indagan los usos habituales que hacen de la plataforma en sus clases tanto teóricas como prácticas. En base a los datos recolectados, se describen las funcionalidades y herramientas empleadas y se analizan las opiniones esbozadas en cuanto a las perspectivas y limitaciones que han detectado.
La dicotomía social y política del servicio de biblioteca: ¿Usuarios o clientes?.
Authors: Meneses Tello Felipe
Published: November 2022

Se comparan dos ideas que se contraponen en la práctica y teoría de la bibliotecología: 1) las bibliotecas al servicio del público y 2) las bibliotecas al servicio del cliente. Esta dualidad se explica con base en dos conceptos esenciales que se hallan en la literatura referente a esa disciplina: usuarios y clientes. Es una dicotomía social y política que coloca en riesgo tanto la noción de servicio público de biblioteca como de servicio de biblioteca pública. En esta perspectiva, se contrasta el préstamo de bienes de dominio público para servir a la comunidad con la compraventa de productos y servicios para la clientela como un elemento del mercado.
Bibliotecas Populares como promotoras de derechos y actores de lo político en la sociedad
Authors: Bocco Andrea Alejandra , Ruiz Santiago
Published: November 2022

El artículo tiene como objetivo compartir el trabajo llevado a cabo por el Programa de Apoyo a Bibliotecas Populares de la Secretaría de Extensión de la Facultad de Filosofía y Humanidades (Universidad Nacional de Córdoba) junto a dos bibliotecas populares ubicadas en distintos barrios de la ciudad de Córdoba.Se parte de una presentación de la misión que este tipo de instituciones tuvieron desde su origen y se problematiza la actualidad de ella. De esta manera, se plantea lo que se consideran dos modelos vigentes y diferentes de Bibliotecas Populares. A partir de aquí, se realiza una caracterización de cada una de las bibliotecas elegidas en relación con la comunidad barrial en la cual se insertan y con la que trabajan.En función de las particularidades que ambas Bibliotecas Populares manifiestan en su accionar, se incorpora la noción de “lo político” de Chantal Mouffe para analizar de qué manera cada una de ellas interviene concretamente en la disputa de sentidos sobre el trabajo comunitario, sobre los derechos humanos, y sobre el alcance mismo de lo que significa ser una BP.
Práctica Profesional Supervisada en Bibliotecología y Documentación radicada en la Oficina de Conocimiento Abierto (OCA) de la Universidad Nacional de Córdoba (UNC).
Authors: Moreyra María Eugenia
Published: November 2022

La Práctica Profesional Supervisada (PPS) de la Licenciatura en Bibliotecología y Documentación de la Escuela de Bibliotecología, Facultad de Filosofía y Humanidades (FFyH) de la Universidad Nacional de Córdoba (UNC) se realiza para la obtención del título de grado.La presente fue llevada a cabo en la Oficina de Conocimiento Abierto (OCA) 1 , de la Universidad Nacional de Córdoba en el período comprendido entre los años 2015 y 2016. Esta, se desarrolla como un proceso personal e individual de acciones de investigación-acción relacionadas con tareas profesionales, del cual surge un vínculo bidireccional en el que, teoría y práctica se complementan mutuamente dando lugar a un nuevo sentido y significado de la realidad profesional.El objetivo perseguido consistió en realizar un aporte concreto a la visibilidad y difusión de la OCA, a través de una metodología audio-visual y expositiva de las herramientas comunicacionales, promocionales y formativas desarrolladas, con el propósito que la experiencia no se convierta en una abstracción teórica o una mera recopilación informativa. La conclusión obtenida apuntó al sentido de responsabilidad que implica la función del bibliotecario como difusor del conocimiento asegurando las condiciones para su accesibilidad, difusión democrática y preservación digital en el tiempo.
Inteligencia emocional en las unidades de información
Authors: Coll María Gabriela , Gamberg Paulina M. , Reynoso Marigen M.
Published: November 2022

En el afán de mejorar el servicio que brindamos, la comprensión e inclusión de la Inteligencia Emocional (IE) nos parece necesario que se comience a implementar en las unidades de información. En tal sentido es que se propone su inclusión en los planes de estudio de las escuelas de bibliotecología y que haya algún entrenamiento para capacitar a futuros profesionales en los diferentes roles que desempeñarán. Se percibe que en este presente reconocer y dirigir las emociones propias y de otros, la IE es cada vez más indispensable. Se verán definiciones, conceptos, competencias emocionales que se enfrentan a paradigmas casi dogmáticos, modelos y algunas reflexiones que siguen sin tener respuesta.
Bibliotecas especializadas en género en Argentina: relevamiento histórico y situación actual.
Authors: Guzevich Maia Ludmila
Published: November 2022

Este artículo forma parte de una investigación realizada para la obtención del título de grado en Bibliotecología y Documentación. El objetivo es identificar las bibliotecas especializadas en género en Argentina, registrar su historia y problemáticas para darles visibilidad.

Es un tipo de estudio exploratorio-descriptivo, con diseño no experimental-transversal. Se realizaron entrevistas de manera remota con el personal que representó a cada una de las cuatro bibliotecas con las que se trabajó. Primeramente, fueron entrevistas exploratorias y luego se profundizó la información con las preguntas que fueron necesarias en cada caso.  

La primera parte del trabajo contiene un relevamiento histórico sobre las bibliotecas de género en nuestro país y la segunda parte incluye la información obtenida de las entrevistas y posteriores conclusiones. Se logró identificar por lo menos cuatro bibliotecas especializadas en género en nuestro país, se detectaron sus falencias, problemáticas y fortalezas, como así también se identificó el trabajo de investigación, comunitario y de extensión cultural que realiza cada institución como otra forma de acercamiento a la comunidad y la difusión del trabajo con perspectiva de género en sus bibliotecas.
Use of Aminophylline to Reverse Acute Kidney Injury in Pediatric Critical Care Patients
Authors: Radel Laura J. , Branstetter Joshua , Jones Tamekia L. , Briceno-Medina Mario , Tadphale Sachin D. , Onder Ali Mirza , Rayburn Mark S.
Published: November 2022

OBJECTIVE

Acute kidney injury (AKI) is a complication encountered in 18% to 51% of pediatric critical care patients admitted for treatment of other primary diagnoses and is an independent risk factor for increased morbidity and mortality. Aminophylline has shown promise as a medication to treat AKI, but published studies have shown conflicting results. Our study seeks to assess the reversal of AKI following the administration of aminophylline in critically ill pediatric patients.

METHODS

We performed a single-institution retrospective chart review of pediatric inpatients who were diagnosed with AKI and subsequently treated with non-continuous dose aminophylline between January 2016 and December 2018. Data were collected beginning 2 days prior to the initial dose of aminophylline through completion of the 5-day aminophylline course.

RESULTS

Nineteen therapies among 17 patients were included in analysis. Twelve of the therapies resulted in resolution of AKI during the study period. We observed urine output increase of 19% (p = 0.0063) on the day following initiation of aminophylline therapy in the subset of patients whose AKI resolved. Trends toward decreased serum creatinine and lower inotropic support were also noted.

CONCLUSIONS

Based on these findings, aminophylline could be considered a potentially effective medication for use as rescue therapy in critically ill children with AKI. Limitations include small study population and retrospective nature. Further research in this area with a larger study population and a randomized control trial would allow for better characterization of the efficacy of aminophylline in reversal of AKI.
Calcium Responsive Pediatric Septic Shock Refractory to Isotonic Crystalloids and Inotropic Agents
Authors: Whelan Aviva J. , Ricci Morgan , Harthan Aaron A. , Deshpande Girish
Published: November 2022

Pediatric septic shock is a life-threatening condition with significant rates of morbidity and mortality. Standard management includes fluid resuscitation, timely antimicrobial administration, and epinephrine or norepinephrine if unresolved with initial management. Additional therapies are not well defined and include vasopressin, hydrocortisone, phenylephrine, levosimendan, dopamine, and others. Many of these agents modify cellular effects of calcium in the smooth muscle. The use of a calcium infusion may improve vasoactivity in the smooth muscle without the use of signaling pathways. Children are more susceptible to the effects of calcium, which may predispose them to enhanced vasoconstriction with the administration of intravenous calcium. We present a case in which a patient on chronic calcium channel blocker therapy presented with septic shock. She continued to remain hypotensive after fluid resuscitation, antibiotics, epinephrine, and norepinephrine. Her blood pressure improved with the initiation of a continuous calcium chloride infusion. Norepinephrine and epinephrine doses were decreased after the initiation of the calcium infusion.
Wondering into the Subjunctive: A Commentary on Thought in Motion
Authors: Carlson David Lee
Published: November 2022

November 16, 2021

Thinking with the papers in this special issue has been an intense spiritual experience.  It is true that for me reading and writing are transmorphic events. The words move into my body, get into my veins, move about, lodge themselves into my stomach and vibrate and mix with memories, molecules, muscles, and thoughts in a sort of flurry that seems rather uncontrollable. I dream about words, lines, and ideas written in this special issue. Language itself is not isolated material; I do not hide out to write or read or cut myself off from the rest of the world to interact with words; they instead become part of me, part of my limited world, the things I eat and drink and shower with. Still, I grapple for words and language to come back when I need to harness them because I stutter and murmur; I'm klutzy, drop things inadvertently and leave the kitchen counter dirty after eating lunch. It is as if I still need to beg for permission to use them when I write, to promise to treat words and sentences with care; and still I need to prove myself with language; it demands my trust; holding onto words and placing them in proper order can seem like trying to carry a plastic bag full of eggs home from a crowded market.
Portal-time and wanderlines: What does virusing-with make possible in childhood research?
Authors: Osgood Jayne , Andersen Camilla Eline , Otterstad Ann Merete
Published: November 2022

This paper emerged from the forces of a pandemic that invited us to wrestle with what ‘virusing-with’ might potentiate in educational research-creation (Manning, 2016a). We sense the Coronavirus perform its agency on childhood in the Capitalocene in new, troubling, and sometimes hopeful ways. Research-creation has compelled us to dwell upon how virusing-with makes attuning differently to the world possible. We contemplate how virusing-with as concept and method holds the potential to disrupt and reformulate ways to undertake research and ways to conceptualise the child. Inspired by Manning’s (2020) recent work in relation to the child of the wanderline, we explore how multiple wanderlines take shape and interweave through research processes.  Through the curation of three threshold events we think-do qualitative research in ways that push ideas and practices about childhood in directions that attend to agentic relationalities between the human, non-human and more-than-human. We argue that practices of virusing-with in portal time provides space for coming-into-relations of differences (Manning, 2016a, p.11) as an ecology of practice that shapes how educational research might be conceptualised and practiced.
Editorial: Thought in Motion
Authors: Flint Maureen A. , Cannon Susan O. , Toledo Whitney
Published: November 2022

Edit from within! Become world! Value, don't evaluate! Lure the feeling! Know not what a body can do! Create with concepts! Make multiple sense! Affirm all that appears! Play the differential! Speculate! Engage relations of tension! Make the relations felt! Create degrees of intimacy! Propose! Transduce! Create affinities of purpose! Forget what you feel! Return the return! Transvaluate! Pay attention! Go to the limit! (Manning, 2008).

What does a philosophy produce? How might philosophy and methodology entangle, blur, respond, engage, interact, contradict, argue, provoke? Erin Manning’s process philosophy attunes researchers to the potential of difference. Manning grounds her philosophy in the notion that doing is thinking, that there is thought in the act, and that philosophy is an experimental practice that coexists with art; it is “pathfinding in the making” (Manning & Massumi, 2013, n.p.). Further, Manning posits that research and creation come together in their product, and the product is always ongoing, always becoming, always in process. Thought with qualitative inquiry, “the conjunction between research and creation […] make[s] apparent how modes of knowledge are always at cross-currents with one another” (Manning, 2016, p. 41).
Not-knowing-in-advance: Trying to think and see as if not doing a PhD.
Authors: Bowstead Helen E.
Published: November 2022

In this piece, the writer offers up a tentative exemplification of how reframing a thesis in terms of what it can do rather than what it is has the potential to generate a joyful-artful engagement with the PhD process and to engender a more response-able relationship with the world. By refusing to engage in the dis-abling processes prescribed by institutional expectations of doctoral study, the act of writing emerges as a powerful antidote to the constraints of the neoliberal, neurotypical, university. Exploring a mode of expression that intertwines text and image, the writer enacts Erin Manning’s philosophical projects of research-creation, artfulness and thought-in-motion.
The Interview-Event-Agencement as Creative Movement and Methodological Disruption
Authors: Ravindran Aisha
Published: November 2022

In her article “Towards a Politics of Immediation,” Erin Manning (2019a) writes about the process of “immediation, the withness of time, of body in the making” (p. 1) that bodies subjectivity through the interstitial experience of/in the event. Drawing from Manning’s movement-oriented philosophy, and thinking-with her concepts of immediation, agencement, interval, and memory of the future, I invite alternate visualizations of interviewing as a research method through my study with international graduate students in a TESOL program at a Canadian university. By shifting focus from human-centred researcher intentionality and pre-determined research tools of the interviewing method, to the entangled human and non-human affective agencies of the interview-participant-voice-recorder-assemblage, I offer possibilities for experiencing the interview-event as an affective ecological attunement. Manning’s concepts also create interferences with existing institutional and TESOL representations and discourses, where multilingual students are often interpellated into rigid identity constructions and difference is seen as deficiency.
Standing in the Midst
Authors: Ramos Ana
Published: November 2022

This paper is an entry point into a different way of doing research: speculative pragmatism. Its roots are to be found in A. N. Whitehead, W. James, H. Bergson, among others. The main concept it fosters for a speculative pragmatism practice is intuition (Bergson, 2007; Deleuze, 1988, 2002; Manning, 2016). Around a discussion on knowledge, the concept of intuition is a pivotal milieu that anchors the basis for thinking-with-research-in-the-making. In the outlining of this background, the classical structure of experience is challenged. It introduces the subjective nature of the event, and shifts the role of objects, as they are normally understood.
The Value of the Useless: Erin Manning, Impact, Higher Education Research, Progress
Authors: Smithers Laura Elizabeth
Published: November 2022

This article brings the work of Erin Manning to bear on common sense practices and conversations of the value of a college education. Manning’s work provides a productive alternative to the neoliberal discourse of college impact that has dominated higher education research for the past half century. Neoliberalism produces the common sense of the value of education as privatized, datafied (or dividuated), and measurable outcomes. This common sense reduces American higher education to the sum of its parts. To produce worlds to which campus marketing departments on occasion gesture, worlds where college produces spaces of community transformation, we must come to re/value progress in excess of measurable outcomes. In a rotating series of revaluations, this paper puts Manning’s concepts to work in both substance and form in four refrains: redefining value in higher education, revaluing the infrathin and the imperceptible, reconceptualizing liberal education, and valuing the useless.
From Technique to Technicity: Non-Methodological Explorations of Chairs, Neurodiversity, and Schooling
Authors: Vasquez Ananí M. , Wells Timothy C. , Basu Marina , Johnson Garrett Laroy
Published: November 2022

In response to the call for this special issue, we draw upon Erin Manning’s (2013, 2016) theorizing of technique and technicity to reconsider schooling and inquiry practices through the chair. The chair is often taken for granted and narrowly conceived through the lens of neurotypicality. By beginning with technique and technicity, this work foregrounds affect, relation and process, rather than object, form and method, so as to dislodge the chair from the sedimented practices of schooling and inquiry. In the emergent fashion of research-creation, this article makes use of genealogy, narrative and theory to explore how the interplay of technique and technicity might engender different modes of chair-ing, and how these modes might speak to concerns of neurodiverse schooling and research methods.
Pedagogy of Suspensions
Authors: Rousell David , Cary Catharine , Kik Agata , Robertson Cole , MacRae Christina
Published: November 2022

This paper takes as its catalyst a series of live art events that took place between London and Manchester in 2019. Thinking in conversation with Erin Manning’s propositions for “minor movements” and the Duchampian “infrathin”, we explore the potential for live art to temporarily suspend the thresholds of perceptibility and permissibility in the public realm. We argue that artful techniques of improvisation carry the potential to suspend capitalistic orderings of time by temporarily confounding the perceived barriers between art and life. Drawing together anarchival traces of improvised movement, sound, image, and thought, the paper is composed of vignettes that sketch the infrathin variations of a “pedagogy of suspensions” as elaborated through live art events in a public park, a moving train, a university gymnasium, and an anechoic sound chamber.
Could hand-eye laterality profiles affect sport performance? A systematic review
Authors: Moreno Miquel , Capdevila Lluis , Losilla Josep-Maria
Published: November 2022

Background

Laterality effects on sports performance have been a field of interest for the sports sciences, especially in asymmetrical sports, which require the preferential use of one side of the body. Some sports in particular involve the visual system and ocular laterality, due to the need to clearly focus on a dynamic object (ball, opponent, projectile, etc.). The relationship between manual and ocular laterality results in two perceptual-motor profiles, one where the dominant hand and eye are ipsilateral (uncrossed hand-eye laterality profile, UC-HELP), and the other where they are contralateral (crossed hand-eye laterality profile, C-HELP).

Methodology

A systematic review of the literature was carried out to determine the prevalence of hand-eye laterality profiles in the different sports modalities and their relationship with psychological factors and sports performance. Searches of PsycInfo, Medline, Scopus and grey literature identified 14 studies (2,759 participants) regarding hand-eye laterality in sports that met the eligibility criteria.

Results

Previous studies have estimated that between 10–30% of the general population exhibit a C-HELP, and 70–90% have an UC-HELP. The results of the reviewed studies indicate that in some sports the percentage of C-HELP is higher in regular and high-level athletes than in the normal population: golf (52.55%), soccer (53%), tennis (42%) and team sports (50.7%). In target sports (archery and shooting) athletes with an UC-HELP seem to have an advantage given the significant concentration of this profile in the highest performing populations (82.3%). In basketball, cricket and golf, the literature reviewed also reported biomechanical differences in the execution of some techniques between the two profiles. We did not find any study in our review that related hand-eye laterality with cognitive, tactical, or psychological aspects of athletes.

Conclusions

These results should be taken with great caution due to the potential bias linked to the methodologies used in the investigations, the heterogeneity in the assessment of hand-eye laterality, the few studies available on the subject and the indirect nature of many of the observed relationships between performance and laterality. For further investigation, we propose a standardized terminology and protocol of hand-eye laterality assessment in sports. The advancement in knowledge about hand-eye laterality profiles, along with the study of the relationship with psychological or tactical-sports patterns, can contribute to more effective development plans for athletes and can be a complement to talent detection.
Correlation of Serum Leptin with Body Mass Index and Insulin Resistance in Polycystic Ovarian Syndrome in a Tertiary Care Centre of Southern Odisha, India
Authors: Jena Prachi , Padhy Rasmita Kumari , Pradhan Devi Prasad , Devi Nirupama
Published: November 2022

Introduction: Leptin is an adipocyte derived hormone encoded by ob gene which serves as a relay link between metabolic signals and brain that regulate the hypothalamic pituitary ovarian axis. Leptin is related with obesity which is a most important cause of Polycystic Ovarian Syndrome (PCOS) in women of reproductive age group. Aim: To evaluate leptin concentration and to analyse its correlation with Body Mass Index (BMI) and insulin resistance in PCOS. Materials and Methods: This case-control study was conducted from December 2018 to December 2019 at Department of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, MKCG Medical College and Hospital, Berhampur, Odisha, India. A total of 60 PCOS subjects, aged between 15-30 years (30 obese PCOS and 30 lean PCOS) and 30 age matched, normal ovulatory healthy controls were included in the study. Parameters such as serum leptin, fasting plasma insulin, Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), Fasting Plasma Glucose (PPG), Postprandial Plasma Glucose (PPPG) were estimated using commercial kits. One-way Analysis of Variance (ANOVA) test was used for data analysis and the Pearson’s correlation method was used to find the correlation between the parameters. Results: The mean age of women in all the three PCOS groups was found to be 22.4±3.13 years. The BMI of obese PCOS patients (31.9±4.7 kg/m2 ) and lean PCOS patients (21.4±2.2 kg/m2 ) were higher than that of healthy controls (20.7±1.8 kg/m2 ) which was statistically significant (p-value <0.001). The serum leptin in obese PCOS were significantly higher (28.0±17.8 ng/mL) than lean PCOS (5.8±2.2 ng/mL) and fasting plasma insulin in lean PCOS were (10.9±2.4 µIU/mL) significantly lower than obese PCOS (30.2±14.8 µIU/mL). Mean serum leptin levels had significant positive correlation with BMI in lean and obese PCOS and insulin resistance in obese PCOS. Conclusion: In the present study, high leptin concentration was observed in PCOS patients and there was positive correlation of leptin with BMI in both lean and obese PCOS groups and leptin was positively correlated with insulin resistance in obese PCOS.
Serum Procalcitonin Correlation with Section Sepsis Severity and Patient Outcomes: An Observational Study
Authors: Jujjuru Sirisha , Panduranga Gautam , Kanugula Shivaraju
Published: November 2022

Introduction: Sepsis is a life-threatening condition of human body. It is caused by improper response of host immune system to various infective conditions. Procalcitonin (PCT) has been a promising biomarker for aiding early diagnosis, risk stratification and treatment in patients with sepsis and septic shock. Aim: To study correlation of serial serum procalcitonin (day1, 3 and 7) with severity of sepsis and patient outcomes (in-hospital stay or mortality). Materials and Methods: The study was a descriptive, observational study conducted at Krishna Institute of Medical Sciences, Secunderabad, Telangana, India, on 100 patients admitted to Medical Intensive Care Unit (MICU), both males and females of age more than 18 years, with sepsis or septic shock, from August 2019 to January 2021. Serum procalcitonin was measured by BRAHMS PCT-Q immunochromatographic assay using a commercially available test kit. Blood, urine and wound cultures were performed to confirm specific infection. The Chisquare test, Fischer’s-exact test and Pearson correlation tests were used to calculate association and correlations amongst qualitative data. Results: Total 100 patients (mean age was 49.9±17.0 years; 62 males and 36 females) were included in the study. A total of 74 patients were observed to be have sepsis and 26 patients Ihad septic shock. Mortality was 36%. There was a positive correlation with Sequential Organ Failure Assessment (SOFA) score on day 1 and 3, but not day 7. PCT was high in 85% of patients on admission (day 1). Higher levels of PCT was observed both in patients with sepsis (82.4%) and septic shock (92.3%), suggesting that it is a good diagnostic marker in these patients. Mean PCT was higher in death patients compared to discharged patients on day 1,3 and 7 (p-value<0.05). Majority of patients (71.8%) with higher PCT on admission stayed in ICU for less than 5 days, whereas over half (53.3%) with normal PCT had a short ICU stay (p-value=0.18). Conclusion: Procalcitonin is a useful marker for early diagnosis of sepsis and septic shock and also severity of infection on admission to ICU. High procalcitonin also predicts mortality and can be a useful tool for rational use of antibiotics in patients admitted to ICU.
The Use of Parthenogenetic Clones to Create Highly Heterogeneous Hybrids of the Silkworm (Bombyx mori L.)
Authors: Larkina E. A. , Mirzakhodjaev B. A. , Mirzakhodjaev A. , Daniyarov U. T. , Radzhabov I. B.
Published: November 2022

Since the entire world's sericulture, to achieve maximum heterosis is based on the feeding of hybrids of only the first generation, therefore, operations for the preparation of pure hybrids are of particular importance. In Uzbekistan, the Sericulture Research Institute has developed new biotechnologies specifically to solve this problem, and genetically modified breeds and parthenogenetic clones have been created on their basis. The unfertilized eggs are thermally activated at t = 46°C for 18 minutes, and the reducing division of meiosis in the germ cells of the silkworm is hampered. As a result, the eggs remain with a diploid set of chromosomes and develop as zygotes. Since silkworm females are heterogamous by sex chromosomes, only female parthenogenetic clones develop from thermally activated eggs. Clonal-breed hybrids, characterized by increased viability of caterpillars – 93,5-98,0% (in the control – 90,0%), the high cocoon shell ratio – 22,1-23,8% (in the control – 22,5%), increased egg-bearing capacity - 622-639 pcs (in the control - 630 pcs), metric number of thread - 3344-4065 units (in the control - 3321), the synchronicity of caterpillar development, uniformity of cocoons, ease of preparation. The technology of thermal activation of unfertilized silkworm eggs for parthenogenetic development is not particularly difficult, therefore clones can reproduce the required number of generations and in an unlimited number of individuals. The second component for hybridization can be males of almost any breed. Clones, due to their genetic constancy, do not need breeding and breeding selection, they do not need to be divided by gender, because they are represented by only one female sex, and have high combinational ability and amicable development.
Challenges in the Research and Development of Orphan Drugs: A Review
Authors: Budarapu Divya
Published: November 2022

Pharmaceutical agents which treat rare medical conditions like orphan or rare diseases are called “orphan drugs”. The name ‘orphan’ itself indicates that the pharmaceutical industries are showing less interest in the development and marketing of drugs intended only for a small number of patients. Difficulty in the diagnosis and therapeutic management of rare disease is the major challenge in the development of orphan drug.

In recent years, progress has been made in the development of orphan drugs by pharma industries due to enactment of different regulations, administration authorities, tax benefits, marketing rights and public awareness by different countries. This review provides an overview of incentives, marketing rights and administrative authorities of different countries like U.S, European Union, South Korea, Japan, Australia and Taiwan.
Characterization of the hormone binding site of natriuretic peptide receptor‐C
Authors: Engel Alfred M , Lowe David G
Published: July 2002

The hormone binding site of rat and human natriuretic peptide clearance receptor (NPR‐C), a single transmembrane receptor, has been further refined by mutagenesis. In addition to residue 188 (rat Ala, human Ile), which completely inverts the pharmacology of the rat and human receptors [Engel et al. (1994) J. Biol. Chem. 269, 17005–17008], we report a second key residue at position 205 (rat Tyr, human Asn) which modulates affinity to a limited number of ligands. Orthologous mutation of both residues results in tighter binding for human and weaker binding for rat NPR‐C. The ligand binding fold of the receptor is formed by at least the first half of the extracellular domain containing two intramolecular disulfide loops, with the two affinity‐modulating residues 188 and 205 in the second loop.
The structure of a reduced mutant T4 glutaredoxin
Authors: Ingelman Margareta , Nordlund Pär , Eklund Hans
Published: July 2002

The mutant T4 glutaredoxin where the active site residues Val15 and Tyr16 have been substituted by Gly and Pro, respectively, crystallizes in a form where the active site disulfide is accessible to reagents. Treatment of the crystals with dithiotreitol causes very subtle changes in the overall glutaredoxin structure. The main differences are seen around the active site where the sulfurs of Cys14 and Cys17 move apart slightly.
Formation and Detachment of Biofilms and Granules in a Nitrifying Biofilm Airlift Suspension Reactor
Authors: van Benthum W. A. J. , Garrido‐Fernández J. M. , Tijhuis L. , van Loosdrecht M. C. M. , Heijnen J. J.
Published: July 2002

The influence of the bare basalt carrier concentration on nitrifying biofilm formation in biofilm airlift suspension (BAS) reactors was studied. The time needed to develop fully covered biofilm particles strongly increased with an increasing initial carrier concentration. This was caused by the increased shear and subsequent higher detachment. During startup the diameter of the biofilm particles increased, leading to a higher biomass concentration, larger biofilm surface area, and lower surface‐specific substrate load. Eventually a “steady state” thickness is obtained, where surface‐specific growth and detachment are equal. The biofilm density decreased with a decreasing bare basalt concentration. The steady state biomass concentration was not very much influenced by the initial carrier concentration. Up to 75% of the produced biomass was retained in the reactors. Maximum biomass retention was found when the initial bare basalt concentration was in between 10 and 30 g·L−1. The continuous detachment of biofilm fragments leads, upon growth of these small fragments, to the formation of granules (biofilms without a carrier). The granules have average density and size equal to those of the biofilm particles. The granules are formed, if the detached biofilm fragments are large enough to be retained by the three‐phase separator on top of the BAS reactor. Since the superficial liquid velocity in the three‐phase separator is scale dependent, granule formation will be influenced by reactor scale, hydraulic load, and dimensions of the three‐phase separator.