bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association between Asphyxia and Interleukin (IL)-6 and IL-1β Levels in Neonates
Authors: Agustina Nenden Nursyamsi , Kosim Muhammad Sholeh
Published: December 2021

Background: Neonatal asphyxia is a respiratory failure during and just after birth. It can cause morbidity and mortality in neonates.Interleukin (IL)-6 and IL-1β are inflammatory cytokines produced by neuronal cells in early response to brain injury due to asphyxia. However, their role in neonatal asphyxiais remain elusive.Objective: To determine theassociation between asphyxia and serumIL-6 and IL-1β levelsin neonates.Methods: Across-sectional study was conducted on neonates diagnosed with moderate to severe asphyxia who hospitalized atthe Dr. Kariadi General Hospital Semarang Indonesia from December 2013 to May 2014. The subjects were examined for serum IL-6 and IL-1β. Blood samples were obtained from umbilical vein in the first 24 hours of life. Serum IL-6 and IL-1β levelswere measured using immunoassay. Dependent variable were IL-6 and IL-1β level. Bivariate analysis was performed using chi-square test, for the assessment of the association between dependent and independent variables. A p-value of less than 0.05 was considered statistically significant.Result: A total of 54 subjectswere enrolled in this study. No significant difference between moderate and severe asphyxia neonatesin term ofsex, birthweight,type of delivery, neonate’s mother age, gestational age, and parity. Levels of IL-6 and IL-1β levels wereincreased significantly in both moderate and severe asphyxiagroups, and the levels were significant higher in the severe asphyxia than that of in the moderate, p=0.003 and p=0.007, respectively.Conclusion:There was association between asphyxia and IL-6 and IL-1β levelsin neonates.IL-6 and IL-1β levelswere increased in neonates with moderate and severe asphyxia, with extend of increase was significant higherin the later.
„Wdzięczność jest pamięcią serca” – reminiscencje w 100. rocznicę urodzin Księdza Profesora Mariana Wolniewicza
Authors: Mikołajczak Mieczysław
Published: December 2021

Niniejszy artykuł służy przypomnieniu kapłana, który w szczególny sposób zapisał się w historii polskiego Kościoła i przez wiele lat był związany z Wielkopolską. Przypomniano działalność dydaktyczno-formacyjną ks. Wolniewicza, a najwięcej uwagi poświęcono jego działalności translatorskiej, której owocem jest starannie przygotowana edycja tzw. Biblii poznańskiej.
Usher syndrome: diagnostic approach, differential diagnoses and proposal of an updated function-based genetic classification
Authors: Bolz Hanno J.
Published: December 2021

Usher syndrome (USH) manifests with congenital and apparently isolated hearing loss, followed by retinal degeneration in later life. Therefore, and because of its high prevalence in the congenitally hearing-impaired population, USH is one of the most relevant deafness syndromes. Next-generation sequencing (NGS)-based testing can now provide most analyzed USH patients with a molecular diagnosis, based on mutations in 11 genes. Given the availability of several excellent articles on the clinical and biochemical basis of USH, this short review focuses on critical assessment of new genes announced as USH genes, clinical and genetic differential diagnoses and therapeutic developments. Because obsolete loci, disproved USH genes and the inclusion of genes whose mutations cause similar phenotypes have increasingly blurred genetic classification, a revision based on phenotype restricted to genes related to the Usher protein complex is proposed.
Genetic counseling and the role of genetic counselors in the United States
Authors: Schaaf Christian P.
Published: December 2021

Genetic counselors represent an indispensable, well-established, and well-integrated group of healthcare providers in the field of genetic and genomic medicine in the United States. They work with other members of the healthcare team to provide information and support to individuals and families concerned with genetic disorders. With more than 5,000 certified genetic counselors in the U.S. and an expected growth of 100 % over the next decade, genetic counseling represents one of the fastest-growing professions in the U.S.

Genetic counselors work in clinical environments (e. g., hospitals), in companies (e. g., genetic testing firms), and as consultants to medical practices and others. Twenty-six states license genetic counselors as practitioners who can bill independently, with licensure applications underway in the remaining 24 states.

Physicians, genetic counselors, and diagnosticians represent the three pillars of comprehensive, integrated genomic medical care. Within this triad, genetic counselors see their primary role in procuring and interpreting family and medical histories, assessing inheritance, quantifying chances of recurrence, facilitating decision-making regarding genetic testing options, and explaining the results of such testing to the respective individuals within the greater context of their families.
Organ-on-a-chip technologies to study neuromuscular disorders: possibilities, limitations, and future hopes
Authors: Lauffer Marlen C.
Published: December 2021

Neuromuscular disorders are a heterogeneous group of diseases ranging from mild to devastating phenotypes depending on the disorder’s origin. Pathophysiologies for many of these disorders are not fully understood and efficient therapies are urgently needed. Recent advances in the field of induced pluripotent stem cells and organ-on-a-chip technologies have brought enormous improvement in modeling neuromuscular diseases. Even complex units, like the neuromuscular junction, can now be built, enabling researchers to study each component of the motor unit by itself or interacting with others, allowing the identification of disease mechanisms. This article aims to introduce these new modeling systems to study neuromuscular disorders and the possibilities of organ-on-a-chip platforms to shed light on disease pathologies and their use for therapy development.
Bringing CCM into a dish: cell culture models for cerebral cavernous malformations
Authors: Skowronek Dariush , Pilz Robin A. , Schwefel Konrad , Much Christiane D. , Felbor Ute , Rath Matthias
Published: December 2021

Cerebral cavernous malformations (CCMs) are vascular lesions that can cause severe neurological complications due to intracranial hemorrhage. Although the CCM disease genes, CCM1, CCM2, and CCM3, have been known for more than 15 years now, our understanding of CCM pathogenesis is still incomplete. CCM research currently focuses on three main disease mechanisms: (1) clonal expansion of endothelial cells with biallelic inactivation of CCM1, CCM2, or CCM3, (2) recruitment of cells with preserved CCM protein expression into the growing lesion, and (3) disruption of endothelial cell–cell junctions in CCMs. We here describe novel CRISPR/Cas9-based in vitro models of CCM and discuss their strengths and limitations in the context of high-throughput drug screening and repurposing approaches.
“What I want to do I do not do”: on bi- and multilingual repertoires and linguistic dislocation in a border town
Authors: Ding Seong Lin , Chee Wei Han
Published: December 2021

Language problems and language barriers are challenges facing not only immigrants but also minorities and people in rural/semirural areas. This study examines individuals’ bi- and multilingual repertoires, language practices and attitudes in a Hokkien-speaking community in Kangar, a semirural town of northern Malaysia bordering Thailand. Through questionnaire surveys and interviews, we investigate how these notions can be used as a means to understand/reflect bilingualism and multilingualism and, more importantly, the potential disparity between what people want to do/say and what people eventually manage to do/say. While there is a shift in language practice from a local- and ancestral origin-induced pattern towards a more “global” and “pan-Chinese” paradigm, the findings also reveal the linguistic “dislocations” of the Hokkien-speaking community across ALL generations regardless of ethnicity. The language issues in the community reflect—and are likely to be reflections of—society at large. The vast contrast between individual/societal linguistic aspirations and the actual linguistic repertoire/communicative competence among the locals indicates the need to redress an absence of major efforts to close urban-rural/city-town/dominant-dominated social divides across the (language) education landscape at the national level.
Translanguaging as a resource for meaning-making at multilingual construction sites
Authors: Kahlin Linda , Keevallik Leelo , Söderlundh Hedda , Weidner Matylda
Published: December 2021

In this article we investigate spoken professional interaction at construction sites in Sweden, where workers from Poland, Ukraine and Estonia are temporarily employed as carpenters, ground workers and kitchen installers. We study how the workers use resources associated with different languages and how these resources are mobilized along with embodied resources for meaning-making. The analysis aims at investigating what social space the workers construct by going between or beyond different linguistic structures, as defined in the theory of translanguaging. The study is based on Linguistic Ethnography and Conversation Analysis is used for close analysis. We focus on instances of translanguaging, such as Swedish-sounding institutionalized keywords, practices of receptive multilingualism and the search for communicative overlaps in repertoires. The findings from busy construction sites show that the stratifying aspect gives some workers a voice in the organization, while others remain silent. Hence, it is primarily professionals functioning as team leaders, who talk to different occupational categories and use resources associated with different languages. The data provide an opportunity to investigate the theory of translanguaging and its transformative power in relation to professional settings that are linguistically diverse, but also strictly hierarchical.
Crisis of Multilateralism and Cities’ Helping Hand
Authors: Szpak Agnieszka
Published: December 2021

This essay shows how cities are stepping into the role of nation-states and are efficiently cooperating with other cities, not only bilaterally but also multilaterally. There are clear symptoms of the crisis of multilateralism that have led cities to attempt to save or fix the multilateral system and solve global problems, notably the current COVID-19 pandemic. Can cities be regarded as a helping hand or as a fix for the multilateral system? With discourse analysis and formal-legal analysis, this article concludes that the answer to the question is positive – cities may help to fix or save the multilateral system.
Bedeutung von Spiritualität in einer ganzheitlichen Psychotherapie
Authors: Ernesti Alina , Neumann Melanie , Weger Ulrich , Edelhäuser Friedrich
Published: December 2021

Spiritualität als ein fundamentales Bedürfnis des Menschseins stellt auch in der Psychotherapie einen wichtigen Einflussfaktor dar. Ziel dieser Studie ist es, die Bedeutung der spirituellen Dimension in der gegenwärtigen Psychotherapie zu erforschen. Dazu wurden sieben ganzheitlich orientierte Therapeutinnen und Therapeuten zu ihrer Arbeitsweise befragt. Anhand Problemzentrierter Interviews wurde exploriert, inwiefern die spirituelle Perspektive der befragten Personen ihre therapeutische Arbeit beeinflusst. Dabei wurde insbesondere der Frage nachgegangen, wie die spirituelle Dimension konkret in die therapeutische Praxis einbezogen und der Umgang mit der weltanschaulichen Passung zwischen Therapeut/-in und Patient/-in gehandhabt wird. Darüber hinaus wurde die Relevanz einer Integration der spirituellen Perspektive in die Psychotherapie thematisiert. Die Interviews wurden mittels Qualitativer Inhaltsanalyse nach Mayring ausgewertet.

Zentrales Ergebnis der Studie ist, dass sich die spirituelle Orientierung der befragten Personen vor allem in ihrer inneren Haltung und in ihrem Therapieverständnis ausdrückt, welches sich durch ein ganzheitliches und spirituelles Menschenbild auszeichnet. Spirituelle Interventionen spielen dagegen eine untergeordnete Rolle. Eine weltanschauliche Beeinflussung der Patientinnen und Patienten wird entschieden abgelehnt. Stattdessen wird ein sensibler und bedürfnisorientierter Umgang mit spirituellen Themen betont. Existenziellen Fragestellungen kommt dabei eine besondere Bedeutung zu. Die Integration einer spirituellen Dimension in die Psychotherapie unter Wahrung professioneller und ethischer Grenzen wird als sehr bereichernd erachtet.
Synthesis, crystal structure and properties of a 2-D Cd(II) coordination polymer based on ferrocenecarboxylate and 4,4′-bipyridine ligands
Authors: Zhong Kai-Long , Quan Jing , Pan Xian-Xiao , Song Wei , Li Bing-Feng
Published: December 2021

A new cadmium(II)-based coordination polymer [Cd3(FcCOO)6(4,4′-bipy)(H2O)2]
n
(FcCOO = ferrocenecarboxylato and 4,4′-bipy = 4,4′-bipyridine) has been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction. The results of a crystal structural analysis has revealed that the title compound consists of two crystallographically unique CdII centers, one in a general position with a five-coordinated and one on an inversion center with a six-coordinated environment. The CdII centers are connected by FcCOO− units to form a metal carboxylate oxygen chain extending parallel to the [100] direction while the 4,4′-bipy ligands further act as bridging linkers of the CdII centers resulting in a layered polymer. In addition, an X-ray powder diffraction and thermal gravimetric analysis and a cyclo-voltammetric characterization of the complex have also been carried out.
Africa and The Decline of The Democracy Debate
Authors: Salih Mohamed
Published: December 2021

The debate on the decline of democracy is not new. It can be traced to the period between the First and Second World Wars, and it resurfaced during the 1970s, followed by the most spectacular dem- ocratic resurgence in human history. This lecture focuses on the current debate on the decline of democracy and downward trends in major democracy assessment indices. Africa is among the three least democratic world regions, with 42% of African countries cur- rently designated as not free.

Measuring the decline or rise of democracy only by the perfor- mance of institutional politics does not provide a complete picture of the issue. Institutional politics does not account for the resil- ience and thriving new spaces where democratic vibrancy and civic engagement prevail. Examples from African countries demonstrate that democracy indices based on institutional politics alone do not account for alternative democratic spaces and practices. This paper is the edited version of the keynote speech delivered by the author at the 6th Pécs African Studies Conference under the theme “African Realities: Conflict and Cooperation”, September 23-24, 2021 – University of Pécs, Hungary.
Dojenje kao društveni fenomen
Authors: Runjić Babić Anđela
Published: December 2021

U ovom se radu razmatra dojenje kao društveni i kulturni fenomen u razdoblju od početaka ljudske civilizacije do kraja osamnaestog stoljeća. Stari narodi bili su svjesni važnosti majčinog mlijeka, a majčinsko dojenje je bilo društvena norma, premda je među višim društvenim slojevima prevladavala tendencija da se dojenje prepusti dojiljama. Iako su liječnici zagovarali dojenje, upravo su društveni stavovi uvelike određivali praksu dojenja. Društveni centri moći, Crkva,
a zatim znanstvena i moralistička elita direktno su utjecali na stavove
prema dojenju i oblikovali ishod same prakse. U osamnaestom stoljeću dolazi do prevrata u društvenoj praksi dojenja dodjeljivanjem uloge dojilje majkama, a dojenje postaje majčinska moralna i građanska dužnost. Ovaj kratak povijesni pregled upućuje na društvenu konstruiranost fenomena dojenja, čija značenja uvijek treba razmatrati unutar specifičnog sociokulturnog i povijesnog konteksta.
Body Traversed
Authors: Bubaš Josipa
Published: December 2021

This paper deals with the notion of non-knowledge through performative experience. It touches upon the thought process mechanism, the possibility of being outside language, the norm, and the meaning of such experience. The performance entitled Non-Human is used as illustration, which means that the study constitutes research in practice. It refers to the notion of zoe as the pure, unbounded life force and separates the importance of identity from the being and becoming. It examines the possibility of entering the prereflexive and expressing it, testing its capacity of communication. Is cogito the only way to identify ourselves as human?
The Competitiveness of Indonesian Cashew Nuts in The Global Market
Authors: Mani Syifa Al , Yudha Eka Purna
Published: December 2021

Indonesia is one of the best quality cashew nut producers and exporters with a 1.2% share in the global market. This is very far from being compared to Vietnam as the world's main exporter of cashew nut controlling 34.07% of the global export market. This study aims to determine the competitive and comparative advantages of cashew nuts from Indonesia and Vietnam in the international market at 2009-2018. The various differences between the two countries make the products produced and distributed vary in quality and quantity. Competitive advantage is analyzed using Porter's diamond theory which consists of four factors to see the competitive advantage of an industry/country. Meanwhile, to determine the comparative advantage of cashew nut trading activities, the Revealed Comparative Advantage (RCA) and Trade Specialization Index (ISP) were calculated. Based on the results of the analysis, it can be seen that Indonesia has an advantage in producing cashew nuts, but has not been able to process it optimally, such as Vietnam which applies special technology and standards in producing cashew nuts. The RCA calculation shows that Vietnam's cashew nut exports have much greater competitiveness than Indonesia, and the ISP calculation results show that both exporters are still importing to maintain the economy and ensure the availability of industrial raw materials in the global market. Trade-related policies need to be considered in order to increase export profits and benefit domestic business actors
Spatial Patterns, Opportunities and Determinants of MSMEs Employment in Township
Authors: Prakoso Jalu Aji , Giovanni Axel , Panjawa Jihad Lukis
Published: December 2021

Research is divided into three sections that contribute to analyse the optimization of employment on large productive population in Magelang, First, to identify the spatial pattern and concentration based on MSMEâ€™s sector by considering comparative benefits. Secondly, to analyse the opportunity in its association with employments in MSMEs. Thirdly, the determinants of employment in MSMEs based on the field of industry, trading and service. This research employs quantitative approach by using Location Quotient and Economic Base Model as analysis for local and regional economic, as well as multiple linier regression analysis. The research indicates that each area demonstrates distinctive spatial pattern and concentration, in terms of industrial sector, trading and service. The opportunity for employment could be notified from basic employment and basic multiplier that exist in each area. There are certain areas that have high potential in new employments once the jobs are available in the sector of industry, trading and service. The determinants of employment of above three sectors have distinctive behaviour in responding the addition of new MSMEs and the addition of revenue. Hence, the appropriate stimulus could be formulated to optimize absorption of productive labour population based on the findings.
Characteristics Affecting Creative Business Income of Leading Subsector Economies in Java
Authors: Purnawan Muhammad Edhie , Taufan Muhammad
Published: December 2021

This study aimed to fill the literature gap on companiesâ€™ characteristics, focusing on the effects of entrepreneurs and business characteristics on the companiesâ€™ income. The companies chosen are the ones in the leading subsector, particularly the case in Java. This study also analyzed which characteristics of entrepreneurs and businesses affected income in the creative industry. The method used in this study was multiple linear regression and standardized beta test, with cross-sectional data taken from the specific survey in creative economy issued by BPS and BEKRAF in 2016. The unit of analysis comprises 822 companies in the leading subsector of the creative industry in Java. The results showed that all of the characteristics of entrepreneurs and businesses had significant and positive effects on the companyâ€™s income. The factors that affected company income are Intellectual Property Rights (IPR) ownerships and the businessâ€™s legal status. The primary factor affecting the income was the number of workers. Meanwhile, for each provincial level in Java, it showed that the number of workers, internet use, and the ownerships of IPR had significant and positive effects, while the IPR ownerships had a substantial magnitude in four provincial levels in Java.
Impact of Strengthening Internal Audit’s Roles towards State Budget Loss
Authors: Qomaryati Nurul , Gultom Yohanna M.L.
Published: December 2021

This research evaluates the effect of strengthening government internal audit’s (APIP) roles on reducing state budget loss in Indonesia. Since 2014, the role of internal audit as a provider of objective quality assurance is strengthened by adding comprehensive consulting activities that are inherent in each cycle of state budget process to make sure that there are no irregularities on managing the stage budget. By using the difference-in-differences (DID) approach, this study analyzes state budget loss data obtained from the Audit Board of Republic of Indonesia (BPK) in 492 cities/districts during 2009-2018. The results show that strengthening internal audit’s roles decreased state budget losses in the regions that have a relatively high capital expenditure by 0.435% and it is significant at 1% level. This finding shows the positive effect of adding a consulting role to government internal audit on reducing the state budget losses in Indonesia.
Mortality by Causes of Death in Metropolices of Ukraine
Authors: LEVCHUK N. M. , SHEVCHUK P. E.
Published: December 2021

Large cities concentrate a substantial part of the educated, highly qualified, and economically active populations. Such social “selection” with the peculiarities of lifestyle determines the distinctive characteristics of the level and structure of mortality. Even though data on deaths by causes of death for the large cities are available in Ukraine, very few studies have analyzed cause-specific mortality in these cities. The objective of the study is to make a comparative analysis of mortality from the most influential causes of death in large cities. The novelty lies in the comparative analysis done for Dnipro, Kyiv, Lviv, Odesa, and Kharkiv for the first time. The study uses the direct method of standardization to calculate standardized death rates by sex in 2005-2019. The results indicate lower all-cause mortality rates for the large city residents compared to the corresponding average country-level indicators. Kyiv, Lviv, and Odesa have lower death rates compared to Dnipro and Kharkiv. In Kyiv and Lviv, this is attributed to lower mortality from almost all major causes of death, while in Odesa this mainly resulted from the extremely low ischemic heart disease mortality. Relatively high mortality from circulatory diseases is observed in Kharkiv and Dnipro. However, in Dnipro, this is associated with a high death rate from coronary heart disease and a very low contribution of cerebrovascular disease, whereas in Kharkiv coronary and cerebrovascular disease death rates are quite high. Mortality rates from diseases of the digestive system in the large cities are found to be the closest to the average in Ukraine (except for Lviv). The neoplasms are the only large group of diseases with a mortality rate that exceeds the average level in Ukraine, in particular for women. Overall, the death rates from most of the causes of death in the large cities demonstrated a positive trend in 2005-2019, with some exceptions. External causes and infectious diseases showed the most decrease while mortality from AIDS and ill-defined causes increased. Also, there were uncertain dynamics of deaths due to suicide and injuries with undetermined intent. Given some specific mortality differences between the cities, some concerns have been raised over the accuracy of the coding of diagnoses. In particular, unusually low mortality from ischemic heart disease was found in Odesa and from cerebrovascular disease in Dnipro, very rare deaths from alcoholic liver disease in Odesa, accidental alcohol poisoning in Kyiv, and a group of other liver diseases in Dnipro. We also assume misclassification of suicides as injuries with undetermined intent in Kharkiv. Our findings highlight the importance of the implementation of automated coding and selection of causes of death that can minimize the number of subjective decisions made by coders and lead to significant improvements in the quality of data.
Transformation of Mortality by Sex in the Four Biggest Cities in Ukraine
Authors: RYNGACH N. O. , SHEVCHUK P. E.
Published: December 2021

Large cities concentrate a substantial part of the educated, highly qualified, and economically active populations. Such social “selection” with the peculiarities of lifestyle determines the distinctive characteristics of the level and structure of mortality. Even though data on deaths by causes of death for the large cities are available in Ukraine, very few studies have analyzed cause-specific mortality in these cities. The objective of the study is to make a comparative analysis of mortality from the most influential causes of death in large cities. The novelty lies in the comparative analysis done for Dnipro, Kyiv, Lviv, Odesa, and Kharkiv for the first time. The study uses the direct method of standardization to calculate standardized death rates by sex in 2005-2019. The results indicate lower all-cause mortality rates for the large city residents compared to the corresponding average country-level indicators. Kyiv, Lviv, and Odesa have lower death rates compared to Dnipro and Kharkiv. In Kyiv and Lviv, this is attributed to lower mortality from almost all major causes of death, while in Odesa this mainly resulted from the extremely low ischemic heart disease mortality. Relatively high mortality from circulatory diseases is observed in Kharkiv and Dnipro. However, in Dnipro, this is associated with a high death rate from coronary heart disease and a very low contribution of cerebrovascular disease, whereas in Kharkiv coronary and cerebrovascular disease death rates are quite high. Mortality rates from diseases of the digestive system in the large cities are found to be the closest to the average in Ukraine (except for Lviv). The neoplasms are the only large group of diseases with a mortality rate that exceeds the average level in Ukraine, in particular for women. Overall, the death rates from most of the causes of death in the large cities demonstrated a positive trend in 2005-2019, with some exceptions. External causes and infectious diseases showed the most decrease while mortality from AIDS and ill-defined causes increased. Also, there were uncertain dynamics of deaths due to suicide and injuries with undetermined intent. Given some specific mortality differences between the cities, some concerns have been raised over the accuracy of the coding of diagnoses. In particular, unusually low mortality from ischemic heart disease was found in Odesa and from cerebrovascular disease in Dnipro, very rare deaths from alcoholic liver disease in Odesa, accidental alcohol poisoning in Kyiv, and a group of other liver diseases in Dnipro. We also assume misclassification of suicides as injuries with undetermined intent in Kharkiv. Our findings highlight the importance of the implementation of automated coding and selection of causes of death that can minimize the number of subjective decisions made by coders and lead to significant improvements in the quality of data.
Institutionalisation of Research Achievements of the Institute of Philosophy in Educational Practices: experience of the «Kyiv School of Philosophy»
Authors: Bugrov Volodymyr
Published: December 2021

The article raises the topic of the specifics of the process of institutionalization of scientific achievements of the H. S. Skovoroda Institute of Philosophy of the NAS of Ukraine, especially the ones of the «Kyiv School of Philosophy» of the second half of the XX century and early XXI century, in the contemporary educational practices of Ukrainian universities on the example of the Taras Shevchenko National University of Kyiv. The celebration in 2021 of the 75th anniversary of the institute, which, together with the university, became the main centre of the Kyiv School of Philosophy, once again highlights the latter's role as a leading subject of institutionalization of the Ukrainian national philosophical tradition of late modern times. One of the most famous innovative academic, humanitarian projects and the first prototypes of an open society in the Ukrainian SSR, this institute was a major domestic participant in world philosophical life during the Cold War and became a centre of growth of the philosophical community in the independent Ukraine. An illustrative example of the introduction of new educational practices in classical universities of Ukraine in the context of digitalization of domestic higher education during the emergence of a global network society is an activity of philosophical societies and startups of the Taras Shevchenko National University of Kyiv and the H. S. Skovoroda Institute of Philosophy of the NAS of Ukraine. It unites their common high scientific and educational potential. The Student Society of Oral History of Philosophy of the Taras Shevchenko National University of Kyiv is one of the most famous. At the centre of its studies is initiated in T. Chaika’s “The Philosopher’s Oral Histories” project reconstruction of scientific biographies of the Kyiv School of Philosophy creators in the context of developing an oral history of philosophy as an alternative historical and philosophical approach/source/genre.
Colgajo perforante de la arteria circunfleja ilíaca superficial para la cobertura de defectos en los miembros
Authors: Valbuena Sebastián Emiliano , Pereira Emanuel Fernando , Conde Braian Nicolás
Published: December 2021

El colgajo perforante de la arteria circunfleja ilíaca superficial se utiliza para la reconstrucción de los miembros, sobre todo, en el dorso de las manos y los pies, en la zona de flexión articular y en cirugía maxilofacial, porque es un colgajo fino, flexible y versátil. Presentamos tres pacientes: dos casos pediátricos para la reconstrucción de secuelas traumáticas de la mano y el dorso del pie, y un adulto para la reconstrucción de una quemadura del dorso de la mano.

Conclusiones: El colgajo perforante de la arteria circunfleja ilíaca superficial es ideal para el dorso de la mano, el pie y los pliegues articulares. Pese a las variaciones anatómicas en el nacimiento de la arteria circunfleja ilíaca superficial, el dominio de las técnicas microquirúrgicas y de la supermicrocirugía permite tomar, con seguridad, un colgajo de dimensiones moderadas o grandes, fino, con baja morbilidad en la zona dadora.
El Puntaje predictivo de resultado en la cirugía reconstructiva de miembros inferiores. Ensayo preliminar
Authors: Vivas Mauro Rafael
Published: December 2021

Introducción: Las secuelas postraumáticas en los miembros son un cuadro de muy difícil abordaje por la gravedad de las lesiones, la falta de protocolos de tratamiento y especialmente por la elección de la mejor alternativa. El objetivo de este estudio fue analizar el resultado del tratamiento reconstructivo con un puntaje prequirúrgico diseñado para tal fin y evaluar su predictibilidad de resultado.

Materiales y Métodos: Se realizó un análisis retrospectivo de tipo cohorte de los resultados del tratamiento con fijación externa en 32 pacientes con secuela traumática de la pierna en los últimos siete años que fueron estadificados con un puntaje preoperatorio elaborado para tal fin y comparado con el resultado obtenido con la tabla de resultados de la ASAMI con dos años de seguimiento mínimo.

Resultados: Se obtuvo una relación directa entre la estadificación prequirúrgica y el resultado final. Dicha relación se ve reflejada en el alto porcentaje de excelentes resultados en pacientes de bajo riesgo (50%) y una tasa del 60% de malos resultados en pacientes de alto riesgo.

Conclusiones: La evidencia actual es contradictoria y se discute cuál es la mejor opción de tratamiento. Los pacientes considerados de alto riesgo tienen un alto porcentaje de malos resultados y tal vez no se beneficien con la cirugía reconstructiva.
Artroplastia invertida lateralizada para artropatía del manguito rotador en pacientes >60 años. Resultados y complicaciones a corto plazo
Authors: Gómez Diego , Dainotto Tamara , Viollaz Gonzalo , Teruya Gustavo , Tedeschi Alejandro , Durán Rafael , Muratore Álvaro
Published: December 2021

Objetivo: Comunicar los resultados y las complicaciones a corto plazo de la artropatía del manguito rotador tratada con artroplastia invertida lateralizada en pacientes >60 años.
Materiales y Métodos: Se identificaron retrospectivamente las artropatías del manguito rotador tratadas con prótesis invertida lateralizada entre 2015 y 2019. Criterios de inclusión: edad >60 años, adecuada función deltoidea y seguimiento mínimo de 24 meses. Antes de la cirugía y después, se registraron el rango de movilidad activa, y los puntajes de Constant-Murley y de la escala analógica visual para dolor. En las radiografías, se determinaron los grados de artrosis glenohumeral, de muescas escapulares y de aflojamiento de la prótesis. Se documentaron las complicaciones, la satisfacción con el procedimiento y la supervivencia del implante.
Resultados: La serie incluyó 40 hombros operados en 38 pacientes (edad promedio 72 años, rango 61-91), con un seguimiento promedio de 25 meses. La elevación anterior aumentó de 82,63° a 136,71° (p <0,001); la rotación externa, de 16,59° a 32,11° (p <0,001) y la rotación interna, de L5 a L3 (p <0,001). El puntaje de Constant-Murley ascendió de 28,25 a 69,97 (p <0,001) y el de dolor disminuyó de 8,34 precirugía a 1,26 poscirugía (p <0,001). La tasa de complicaciones fue del 12,5% y la supervivencia del implante, del 97,4%.
Conclusiones: La artroplastia invertida lateralizada es una excelente alternativa quirúrgica para la artropatía del manguito rotador en pacientes >60 años, los resultados son satisfactorios, la tasa de complicaciones es aceptable y la supervivencia del implante es del 97,4%.
Tratamiento de las fracturas femorales periprotésicas Vancouver B3 con injerto óseo impactado. Supervivencia y complicaciones
Authors: Díaz Dilernia Fernando , Oñativia José Ignacio , Slullitel Pablo , Buttaro Martín
Published: December 2021

Objetivos: El tratamiento de elección para las fracturas femorales periprotésicas Vancouver B3 aún no está definido. Por este motivo, nos propusimos analizar la tasa de complicaciones de la técnica de injerto óseo impactado con un vástago cementado cuando se utiliza para tratar estas fracturas. Materiales y Métodos: Estudiamos retrospectivamente 33 fracturas femorales periprotésicas B3 tratadas con la técnica de injerto óseo impactado operados entre 2000 y 2016, analizando la tasa de complicaciones. La mediana de seguimiento fue de 75 meses (RIC 36-111). La mediana de edad fue de 78 años (RIC 74-83). La mediana del defecto óseo femoral fue 3 (RIC 3-3) según la clasificación de la Endo-Klinik. Se realizó un análisis de regresión múltiple para determinar los factores de riesgo asociados a complicaciones, las variables incluidas fueron: cantidad de cirugías previas, diámetro de la nueva cabeza femoral y defecto óseo femoral. Resultados: Se realizó una cirugía de revisión en dos etapas en cuatro pacientes. Se registraron cinco fallas asépticas del implante y dos luxaciones en toda la serie. El análisis de regresión lineal multivariable mostró una asociación significativa entre el grado del defecto óseo femoral Endo-Klinik y la tasa de complicaciones(p = 0,04). Conclusión: La reconstrucción femoral con la técnica de injerto óseo impactado para tratar fracturas periprotésicas Vancouver B3 provocó una alta tasa de complicaciones.
Artroplastia total de rodilla posterior a osteotomía tibial alta. Estudio retrospectivo comparativo entre osteotomías sustractivas y aditivas
Authors: Tillet Fernando , Rodríguez Joaquín Aníbal , Del Sel Hernán , Lopreite Fernando Adrián
Published: December 2021

Introducción: El reemplazo total de rodilla luego de una osteotomía tibial alta plantea dificultades técnicas adicionales. El objetivo de este estudio fue analizar los resultados clínicos y radiográficos de la conversión a reemplazo total de rodilla luego de una osteotomía tibial alta y comparar la evolución de los pacientes con una osteotomía de cierre (sustractiva) o de apertura (aditiva) previa.Materiales y Métodos: Se analizó retrospectivamente una serie de 46 artroplastias de rodilla realizadas entre 1997 y 2019, en 39 pacientes con antecedente de osteotomía tibial alta. Se evaluaron los parámetros clínicos y radiográficos antes de la artroplastia y después, determinando el eje femorotibial, la caída tibial  posterior, el valor de Insall-Salvati y el Knee Society Score. También se compararon los resultados en pacientes con antecedente de osteotomía tibial sustractiva vs. aditiva.
Resultados: El seguimiento promedio fue de 5.72 años (mín. 1, máx. 19). El Knee Society Score de la serie tuvo una mejoría promedio de 42,3 a 79,8. La caída tibial posterior y el índice de Insall-Salvati no sufrieron grandes modificaciones luego de la cirugía. La supervivencia promedio de la osteotomía aditiva hasta la conversión a reemplazo total de rodilla fue de 5.5 años, mientras que la de la sustractiva, de 13.5 años.
Conclusiones: Pese a la dificultad técnica que puede plantear, el reemplazo total de rodilla luego de una osteotomía tibial alta valguizante tuvo una buena evolución clínico-radiográfica a corto y mediano plazo, y el tipo de osteotomía no repercutió en los resultados luego de la artroplastia
40º aniversario de una publicación introduciendo un implante aún vigente: “ENDO model”
Authors: Autorino Carlos María
Published: December 2021

En 2021, se cumplen 40 años de la publicación original que describió al implante “intracondilar con capacidad rotatoria Endo-Model”, evolución del diseño precedente St. George, ahora capaz de proveer doble grado de libertad de movimiento y reducir la tensión en la interfase cemento-hueso. Condición singular es que dicha publicación no es referida en estudios bibliométricos, a pesar de lo cual su indicación electiva está aún vigente tras cuatro décadas. Un trabajo merece la calificación de “clásico” no exclusivamente por el volumen de citaciones, sino fundamentalmente por la confianza que inspira la aplicación de su contenido en el largo plazo. Contemporáneamente, todas las compañías de la industria de implantes que lideran el mercado internacional han incorporado en sus catálogos un modelo propio de implante a bisagra rotacional. La magnitud de constricción comparativa es un dilema y, por ende, materia de discusión. Contemporáneamente aplicando la tecnología de sensores inerciales se ha logrado resolver la cuestión: la bisagra rotacional ofrece menor constricción que el implante de constricción condilar.
O entrelaçar da história e da ficção em Só as mulheres sangram
Authors: Henriques Elizane Souza dos Santos , Rodrigues Inara de Oliveira
Published: December 2021

Neste estudo, problematizamos as relações entre a história e a ficção em quatro, dos nove, contos que compõem a narrativa afro-brasileira Só as mulheres sangram, escrita por Lia Vieira (2017). A obra aponta à vulnerabilidade social da população negra no Brasil, e às heranças escravagista, colonial e patriarcal. Para desvendar tais questões a pesquisa, bibliográfica e analítica, tem como base teórica as relações entre a História e a Literatura (PESAVENTO, 2003; RICOUER, 1997; GINZBURG, 2007); a concepção de literatura afro-brasileira (DUARTE; 2016); e a Teoria do conto (GOTLIB, 2012; MARIA, 2004). A análise permitiu concluir que os contos mantêm diálogo constante com a realidade histórica na qual se inserem. Ao dar ênfase à afetividade e a ancestralidade do povo negro, bem como à emancipação feminina, tais narrativas valorizam a identidade e o lócus enunciativo desses sujeitos, fomentando, assim, reflexões sobre a necessidade de enfrentamento das desigualdades e dos fluxos hegemônicos.
Virgílio de Lemos
Authors: Leal Luciana Brandão
Published: December 2021

Este artigo apresenta leitura da obra poética de Virgílio de Lemos, ortônimo, considerando os ciclos representativos da escrita desse autor moçambicano, especialmente o que foi produzido entre 1944 e 1963. Para tanto, consideram-se os trânsitos e diásporas desse poeta e de sua poesia pelas ilhas moçambicanas e pelas águas do Oceano Índico. Analisam-se, ainda, outros trânsitos de Virgílio de Lemos, como a opção pelo barroco estético. Esses trânsitos revelam uma lírica rebelde e transgressora em relação ao modelo literário predominante em Moçambique, fortalecendo uma atitude estética que ecoa subversão e resistência à repressão colonialista.
Do exílio e do retorno ao útero materno
Authors: Amorim Moisés Carlos de , Silva María Emilia Landaeta
Published: December 2021

A poesia nacionalista de Casimiro de Abreu, influenciada pela 1ª geração romântica, configura-se numa linguagem simbólica em torno da terra natal, estabelecendo mitos e arquétipos que possibilitam representar o sentimento de “regresso ao lar”, entrevisto na sua produção lírica de exaltação “matriótica”, termo semanticamente mais adequado para ilustrar o nacionalismo. Este sentimento, instituído na tensão entre o inconsciente pessoal e o inconsciente coletivo, funda a imagem da Grande Mãe benfazeja como isomorfa à nação. Desde as primeiras recordações da infância sublimada pela imagem do berço, até o findar da existência, estabelecida pela imagem do sepulcro, os valores de intimidade maternal povoam o imaginário lírico de Casimiro de Abreu. Tais imagens, além de fortalecer o símbolo da Grande Mãe, também apontam uma reflexão de que a terra natal (isomorficamente materna) transmite paz ao sujeito lírico, tornando-se a cavidade uterina para onde voltará os seus despojos.
Podia arredondar a boca e soprar verdades, nem por isso eu confiaria
Authors: Canilha Samla Borges
Published: December 2021

Autora de uma potente e pouco tratada obra, a portuguesa Mafalda Ivo Cruz tem uma escrita não raro considerada hermética devido à fragmentação, à não linearidade e à diversidade de vozes, muitas vezes apresentadas de forma caótica e associadas a uma ruptura espaciotemporal. Em Oz (2006), essas características estão a serviço de uma narrativa que trata da prisão de um artista – Oz – pelo abuso sexual de sua vizinha. A justiça do encarceramento é posta em questão, e a narrativa baseia-se nessa dúvida. Para tanto, Cruz recorre a um texto composto por diferentes perspectivas e vozes narrativas, de forma que as falhas de memória de uma personagem e os pontos omitidos são preenchidos por outras, formando um todo coeso. Isso, porém, não significa necessariamente clareza, mas pelo contrário: temos que tentar, sozinhos, organizar o caos em que nos colocados. Resolver o mote da narrativa, acaba, assim, ultrapassando a simples descoberta do culpado, principalmente porque somos guiados nessa investigação por vozes que não sabemos se confiáveis – incluindo, aliás, um possível criminoso. Com isso, a rede estética em que Cruz nos enreda acaba mostrando-se muito mais importante que a resolução da investigação criminosa.
O mato e a cidade angolanos, o subúrbio e a zona sul cariocas
Authors: Passos Arthur Almeida
Published: December 2021

Neste artigo, analisamos a construção do espaço em duas narrativas das literaturas de língua portuguesa – “O feto”, do autor angolano João Melo, e “Monólogo de Tuquinha Batista”, do autor brasileiro Aníbal Machado –, com ênfase na composição das zonas rural e urbana de Angola, no primeiro caso, e do subúrbio e zona sul da cidade do Rio de Janeiro, no segundo. Nossa hipótese é que esses espaços, tal como tecidos pelo trabalho autoral nos olhares e vozes das narradoras de cada conto, apresentam-se como diametralmente opostos: por um lado, o mato e o subúrbio seriam considerados de modos inteiramente positivos pelas referidas enunciadoras; por outro, a cidade e a zona sul seriam tratadas de formas completamente negativas pelas mesmas personagens. Para verificar se essa suposição interpretativa se sustenta ou não, recorremos, como referencial analítico específico, ao conceito de espaço como focalização, ponto de vista ou perspectiva, e ressaltamos, como princípios analíticos gerais, a condição das narradoras enquanto sujeitos literários e a natureza estética dos espaços em destaque.
Apresentação
Authors: Angelini Paulo Ricardo Kralik , Teixeiro Alva Martínez
Published: December 2021

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Tolerancia in vitro de cultivares de Rubus spp. a estrés hídrico simulado con manitol
Authors: Millones Carlos , Vásquez Ernestina
Published: December 2021

Introducción. La caracterización de cultivares de Rubus spp. tolerantes al estrés hídrico en campos experimentales es complicado por la dificultad de controlar los factores externos del medio ambiente donde son instalados. La inducción de estrés in vitro es una herramienta eficiente para estudiar los mecanismos de respuesta de las plantas y se emplea en los programas de mejoramiento para la selección de genotipos tolerantes al estrés hídrico. Objetivo. Evaluar la respuesta morfológica y fisiológica in vitro de los explantes en tres cultivares y la accesión silvestre de Rubus spp. bajo condiciones de estrés hídrico simulado con manitol. Materiales y métodos. El estudio se realizó en el Laboratorio de Biología de la Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Perú, durante el año 2020. Se empleó un diseño completamente al azar con arreglo factorial (Factor A: cuatro genotipos y Factor B: potenciales hídricos simulados con manitol: 0, -0,2, -0,3 y -0,4 MPa) y cuatro explantes por unidad experimental. Resultados. Los cultivares respondieron de manera distinta bajo estrés hídrico simulado con manitol. Los cultivares Navaho y Tupy registraron mayor tolerancia. Conclusión. Los rasgos morfológicos y fisiológicos relacionados con la longitud de raíz, el contenido hídrico de brote, raíz y hoja permitieron identificar cultivares de Rubus spp. tolerantes al estrés hídrico simulado con manitol en la fase vegetativa.