bluuebunny/crossref_metadata_2025 huggingface dataset:
New Strategies for Clinical Trials in Autism Spectrum Disorder
Authors: Pauly Rini , Ziats Catherine A. , Abenavoli Ludovico , Schwartz Charles E. , Boccuto Luigi
Published: November 2020

Background:

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that poses several
challenges in terms of clinical diagnosis and investigation of molecular etiology. The lack of knowledge on the pathogenic
mechanisms underlying ASD has hampered the clinical trials that so far have tried to target ASD behavioral symptoms. In
order to improve our understanding of the molecular abnormalities associated with ASD, a deeper and more extensive
genetic profiling of targeted individuals with ASD was needed.

Methods:

The recent availability of new and more powerful sequencing technologies (third-generation sequencing) has
allowed to develop novel strategies for characterization of comprehensive genetic profiles of individuals with ASD. In
particular, this review will describe integrated approaches based on the combination of various omics technologies that
will lead to a better stratification of targeted cohorts for the design of clinical trials in ASD.

Results:

In order to analyze the big data collected by assays such as whole genome, epigenome, transcriptome, and
proteome, it is critical to develop an efficient computational infrastructure. Machine learning models are instrumental to
identify non-linear relationships between the omics technologies and therefore establish a functional informative network
among the different data sources.

Conclusion:

The potential advantage provided by these new integrated omics-based strategies is to better characterize the
genetic background of ASD cohorts, identify novel molecular targets for drug development, and ultimately offer a more
personalized approach in the design of clinical trials for ASD.
COVID-19 Outbreak: Neurological Manifestations Beyond Cough and Fever
Authors: Kumar Saurabh , Dwivedi Divya , Chopra Madhu
Published: November 2020

COVID-19 is one of the most disastrous respiratory diseases (after the 1918 influenza
outbreak) spreading in the community. So far, it has killed 7,37,417 individuals. High variability in
the viral genome and its greater ability to spread in the human community are badly affecting the
comorbid individuals. Although infected individuals mainly possess respiratory issues, neurological
manifestations in these individuals cannot be overlooked. The literature search is based on the
recent development in the concerned field. We searched databases like PubMed, Google Scholar,
and ScienceDirect using the keywords “COVID-19”, “neurological manifestations”, “CNS”, and
“PNS”. The major neurological complications observed in these patients are encephalitis, necrotising
haemorrhagic encephalopathy, Guillain-Barré Syndrome, smell/taste impairment, epileptic
seizures, and abnormal states of consciousness. COVID-19 infection is just more than a cough, fever,
and respiratory illness; it can cause indirect neurological complications in infected patients. It is
therefore advised to treat and have a careful observation of the COVID-19 patients for neurological
manifestations.
Mobile Health Intervention to Close the Guidelines-To-Practice Gap in Hypertension Treatment: Protocol for the mGlide Randomized Controlled Trial (Preprint)
Authors: Lakshminarayan Kamakshi , Murray Thomas A , Westberg Sarah M , Connett John , Overton Val , Nyman John A , Culhane-Pera Kathleen A , Pergament Shannon L , Drawz Paul , Vollbrecht Emily , Xiong Txia , Everson-Rose Susan A
Published: November 2020

BACKGROUND

Suboptimal treatment of hypertension remains a widespread problem, particularly among minorities and socioeconomically disadvantaged groups. We present a health system–based intervention with diverse patient populations using readily available smartphone technology. This intervention is designed to empower patients and create partnerships between patients and their provider team to promote hypertension control.

OBJECTIVE

The mGlide randomized controlled trial is a National Institutes of Health–funded study, evaluating whether a mobile health (mHealth)-based intervention that is an active partnership between interprofessional health care teams and patients results in better hypertension control rates than a state-of-clinical care comparison.

METHODS

We are recruiting 450 participants including stroke survivors and primary care patients with elevated cardiovascular disease risk from diverse health systems. These systems include an acute stroke service (n=100), an academic medical center (n=150), and community medical centers including Federally Qualified Health Centers serving low-income and minority (Latino, Hmong, African American, Somali) patients (n=200). The primary aim tests the clinical effectiveness of the 6-month mHealth intervention versus standard of care. Secondary aims evaluate sustained hypertension control rates at 12 months; describe provider experiences of system usability and satisfaction; examine patient experiences, including medication adherence and medication use self-efficacy, self-rated health and quality of life, and adverse event rates; and complete a cost-effectiveness analysis.

RESULTS

To date, we have randomized 107 participants (54 intervention, 53 control).

CONCLUSIONS

This study will provide evidence for whether a readily available mHealth care model is better than state-of-clinical care for bridging the guideline-to-practice gap in hypertension treatment in health systems serving diverse patient populations.

CLINICALTRIAL

Clinicaltrials.gov NCT03612271; https://clinicaltrials.gov/ct2/show/NCT03612271

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/25424
Identification of Atherosclerotic and Cardiovascular Clinical Phenotypes in Spanish Electronic Health Records: Assessment of an Automated Information Extraction System. (Preprint)
Authors: Hernández-Medrano Ignacio , Serrano Marisa , Collazo Sergio , López-Ballesteros Ana , Coll Blai , Lozano Javier
Published: November 2020

BACKGROUND

Research efforts to develop strategies to effectively identify patients and to reduce the burden of cardiovascular diseases is essential for the future of the health system. Most research studies have used only coded parts of electronic health records (EHRs) for case-detection, obtaining missed data cases and reducing study quality. Incorporating information from free-text into case-detection through Natural Language Processing (NLP) techniques improves research quality. SAVANA was born as an innovating data-driven system based on NLP and big data techniques designed to retrieve prominent biomedical information from narratives clinic notes and to maximize the huge amount of information contained in Spanish EHRs.

OBJECTIVE

The aim of this work if to assess the performance of SAVANA when identifying concepts within the cardiovascular domain in Spanish EHRs.

METHODS

SAVANA is a platform for acceleration of clinical research, based on real-time dynamic exploitation of all the information contained in EHRs corpora that uses its own technology (EHRead) to allow unstructured information contained in EHRs to be analysed and expressed by means of medical concepts that contain the most significant information in the text.

RESULTS

The evaluation corpus consisted of a stratified random sample of patients from 3 Spanish sites. For site 01, the corpus contained a total of 280 mentions of cardiovascular clinical entities, where 249 were correctly identified, obtaining a P=0.93. In site 02, SAVANA correctly detected 53 mentions of cardiovascular entities among 57 annotations, achieving a P=0.98; and in site 03, among 165 manual annotations, 75 were correctly identified, yielding a P= 0.99.

CONCLUSIONS

This research clearly demonstrates the ability of SAVANA at identifying mentions of atherosclerotic/cardiovascular clinical phenotype in Spanish EHRs, as well as retrieving patients and records related to this pathology.
A Newly Developed Online Peer Support Community for Depression (Depression Connect): Qualitative Study (Preprint)
Authors: Smit Dorien , Vrijsen Janna N , Groeneweg Bart , Vellinga-Dings Amber , Peelen Janneke , Spijker Jan
Published: November 2020

BACKGROUND

Internet support groups enable users to provide peer support by exchanging knowledge about and experiences in coping with their illness. Several studies exploring the benefits of internet support groups for depression have found positive effects on recovery-oriented values, including empowerment. However, to date, little attention has been paid to user narratives.

OBJECTIVE

This study aims to capture the user perspective on an online peer support community for depression with a focus on the modes of user engagement and the benefits users derive from participation in the forum.

METHODS

In this qualitative study, we conducted 15 semistructured interviews with users of Depression Connect, a newly developed online peer support community for individuals with depression. Combining a concept-driven and a data-driven approach, we aimed to gain insight into what users value in our Depression Connect platform and whether and how the platform promotes empowerment. We performed a thematic analysis to explore the merits and demerits reported by users by using theoretical concepts widely used in internet support group research. In the subsequent data-driven analysis, we sought to understand the relationship between different styles of user engagement and the participants’ experiences with the use of Depression Connect. Data analysis consisted of open, axial, and selective coding. To include as diverse perspectives as possible, we opted for purposive sampling. To verify and validate the (interim) results, we included negative cases and performed member checks.

RESULTS

We found participation in Depression Connect contributes to a sense of belonging, emotional growth, self-efficacy, and empowerment. “Getting too caught up” was the most frequently reported negative aspect of using Depression Connect. The deployment and development of three participation styles (ie, reading, posting, and responding) affected the perceived benefits of Depression Connect use differentially, where the latter style was central to enhancing empowerment. “Being of value to others” boosted the users’ belief in their personal strength. Finally, Depression Connect was predominantly used to supplement offline support and care for depression, and it mainly served as a safe environment where members could freely reflect on their coping mechanisms for depression and exchange and practice coping strategies.

CONCLUSIONS

Our findings shed new light on user engagement processes on which internet support groups rely. The online community primarily served as a virtual meeting place to practice (social) skills for deployment in the offline world. It also allowed the members to learn from each other’s knowledge and experiences and explore newly gained insights and coping skills.
Facilitator Contact, Discussion Boards, and Virtual Badges as Adherence Enhancements to a Web-Based, Self-guided, Positive Psychological Intervention for Depression: Randomized Controlled Trial (Preprint)
Authors: Moskowitz Judith Tedlie , Addington Elizabeth L , Shiu Eva , Bassett Sarah M , Schuette Stephanie , Kwok Ian , Freedman Melanie E , Leykin Yan , Saslow Laura R , Cohn Michael A , Cheung Elaine O
Published: November 2020

BACKGROUND

Adherence to self-guided interventions tends to be very low, especially in people with depression. Prior studies have demonstrated that enhancements may increase adherence, but little is known about the efficacy of various enhancements in comparison to, or in combination with, one another.

OBJECTIVE

The aim of our study is to test whether 3 enhancements—facilitator contact (FC), an online discussion board, and virtual badges (VB)—alone, or in combination, improve adherence to a self-guided, web-based intervention for depression. We also examined whether age, gender, race, ethnicity, comfort with technology, or baseline depression predicted adherence or moderated the effects that each enhancement had on adherence.

METHODS

Participants were recruited through web-based sources and, after completing at least 4 out of 7 daily emotion reports, were sequentially assigned to 1 of 9 conditions—the intervention alone; the intervention plus 1, 2, or all 3 enhancements; or an emotion reporting control condition. The intervention was a positive psychological program consisting of 8 skills that specifically targeted positive emotions, and it was delivered over 5 weeks in a self-guided, web-based format. We operationalized adherence as the number of skills accessed.

RESULTS

A total of 602 participants were enrolled in this study. Participants accessed, on average, 5.61 (SD 2.76) of 8 skills. The total number of enhancements participants received (0-3) did not predict the number of skills accessed. Participants who were assigned to the VB+FC condition accessed significantly more skills than those in the intervention only conditions. Furthermore, participants in arms that received the combination of both the VB and FC enhancements (VB+FC and VB+FC+online discussion board) accessed a greater number of skills relative to the number of skills accessed by participants who received either VB or FC without the other. Moderation analyses revealed that the receipt of VB (vs no VB) predicted higher adherence among participants with moderately severe depression at baseline.

CONCLUSIONS

The results suggested that the VB+FC combination significantly increased the number of skills accessed in a self-guided, web-based intervention for elevated depression. We have provided suggestions for refinements to these enhancements, which may further improve adherence.

CLINICALTRIAL

ClinicalTrials.gov NCT02861755; http://clinicaltrials.gov/ct2/show/NCT02861755
Should One Stop or Turn to Avoid an Automobile Collision?
Authors: Riveros Héctor G. , Rosas David Riveros
Published: November 2020

N/a
Narrative Exposure Therapy Intervention and Management of Memory Intrusion Symptoms of Traumatic Stress among Young People in Kakuma Division, Turkana County of Kenya
Authors: Inyang Ime Okon , Gitau Dr. Susan , Osoro Dr. Eric
Published: November 2020

Kakuma refugee camp is currently the home of 196,666 people who fled from their various countries due to civil war and organized violence. Young people form 20% of this population. These young people live with constant reminders of negative memories of their traumatic experience. Against this background, this study sought to assess the young people’s traumatic stress with the use of post-traumatic stress disorder checklist for DSM-5 (PCL-5) tool. The study adopted narrative exposure therapy framework and intervention for traumatic stress management. The study used quasi-experimental research design whereby the researcher adopted a non-equivalent groups design. This design involved one treatment group and one control group. The study sampled 110 participants through multistage cluster and proportionate sampling. Descriptive and inferential statistics were used to analyse the data with the aid of statistical programme for social sciences (SPSS) version 23. Independent sample t-test was used to list the statistical significant differences between the means in the pre-test and post-test scores for the groups. The researcher established that Narrative exposure therapy intervention was effective in management of memory intrusion symptoms of traumatic stress among young people in Kakuma division, Turkana County of Kenya.
Analysis of Reasons for Chinese College Students’ Lack of Oral English Proficiency
Authors: Fan YANG
Published: November 2020

Chinese college students’ lack of oral English proficiency has aroused many attentions during the College English Reform in recent years. The purpose of this article is to (a) summarize findings from the literature of challenges existed in oral English teaching in Chinese higher education and (b) find reasons for Chinese college students’ lack of oral English proficiency. The overarching question of this article is what are reasons for Chinese college students’ lack of oral English proficiency. Several reasons for Chinese college students’ lack of oral English proficiency including teacher knowledge, students’ willingness to communicate, assessment factors, and contextual constraints have been identified from the literature. This study hopes to provide references to the development of Chinese College English Reform in respect to oral English teaching.
ПРЕЦИЗИОННЫЙ СЕНСОР ДАВЛЕНИЯ НА БАЗЕ МОНОКРИСТАЛЛИЧЕСКОГО КРЕМНИЯ
Authors: Адамова А. , Цивинская Т.
Published: November 2020

Описан процесс создания сенсора давления на основе кристалла монокристаллического кремния, включая решение проблемы влияния деформаций на показания по измеряемой величине. Приведены преимущества сенсора по сравнению с тонкопленочным емкостным датчиком аналогичного назначения.
ОБЛАЧНАЯ ПЛАТФОРМА ALTIUM 365: КАК УПРОСТИТЬ ВЗАИМОДЕЙСТВИЕ ПРОЕКТИРОВАНИЯ И ПРОИЗВОДСТВА ЭЛЕКТРОНИКИ
Authors: Демидов П.
Published: November 2020

Компания Altium выпустила облачную платформу Altium 365, которая позволяет упростить взаимодействие проектировщиков и производителей электронных устройств на базе печатных плат, обеспечивая надежное хранение проектных данных и доступ к ним из любой точки мира. В статье рассмотрены основные функциональные возможности платформы.
Impacto de las tecnologías de extracción verdes para la obtención de compuestos bioactivos de los residuos de frutos cítricos
Authors: Wong-Paz Jorge Enrique , Aguilar-Zárate Pedro , Veana Fabiola , Muñiz-Márquez Diana Beatriz
Published: November 2020

En la actualidad, las técnicas de extracción convencionales como la maceración, soxhlet y el calentamiento-reflujo entre otras, han seguido utilizándose debido a su principal ventaja como procesos de extracción más económicos. Sin embargo, estas metodologías presentan diversas desventajas, como largos tiempos de extracción y requerimiento de altas cantidades de disolventes. Es por lo hasta aquí expuesto que se han implementado metodologías de extracción alternativas que cumplen con los principios de la química verde, como son las extracciones asistidas: por ultrasonido (EAU), microondas (EAM) y con fluidos supercríticos (EAFS). Estos métodos de extracción, alternos a los convencionales, han logrado despertar el interés de los investigadores como futuras perspectivas de aplicación, con altos rendimientos, para la recuperación de compuestos bioactivos de los residuos de frutos cítricos, en menor tiempo de extracción, empleando disolventes verdes. El objetivo de la presente revisión es dar a conocer el impacto de las metodologías de extracción alternativas con un enfoque en el aprovechamiento y revalorización de los residuos de frutos cítricos, debido a que éstos presentan una gran diversidad de compuestos de interés para la industria farmacéutica, alimentaria y biotecnológica.
Evaluación de la toxicidad aguda y composición química de aceite refinado de Moringa oleifera cultivada en México
Authors: Pérez-Pérez Viridiana , Alamilla-Beltrán Liliana , Jiménez-Martínez Cristian , Pereyra-Castro Silvia Del Carmen , Ortiz-Moreno Alicia , Plazola-Jacinto Carla Patricia , Camacho-Díaz Brenda H. , Hernández Ortega Marcela
Published: November 2020

El aceite de Moringa oleifera está compuesto principalmente de ácido oleico, linoleico y α-linolénico, también contiene fosfolípidos y otros componentes minoritarios, como enzimas, alcaloides y glucosinolatos, compuestos que pueden generar características no deseadas y/o toxicidad, sin embargo, éstos pueden eliminarse mediante un proceso de refinación. El objetivo de este trabajo fue evaluar el efecto de la refinación química sobre la toxicidad aguda, la composición de ácidos grasos, y las propiedades fisicoquímicas del aceite de semilla de M. oleifera de una variedad mexicana, para ésto, el aceite se extrajo por prensado mecánico de las semillas para someterse a refinación química. Al aceite crudo y refinado se les determinó toxicidad aguda probada en un modelo murino, así como también el perfil de los ácidos grasos, los índices de yodo, saponificación y peróxido, además de la acidez, y capacidad antioxidante. Los resultados mostraron que el aceite de semilla de M. oleifera no presentó toxicidad aguda en el intervalo de 300-2,000 mg/kg; por lo que podría ser utilizado para consumo humano. El proceso de refinación no tuvo efecto significativo (p < 0.05) sobre el contenido del ácido oleico (69%), linoleico (0.74%) y α-linolénico (1.97%). Después del proceso de refinación, aumentó el valor del índice de yodo y de saponificación, mientras que el índice de peróxido, la acidez, el contenido de β-caroteno y la capacidad antioxidante disminuyeron.
Meme Implicature Using the Word 'Tenggelamkan'
Authors: Aulia Sela Wildaan , Nurhayati
Published: November 2020

The majority of Indonesians who are known to use social media as a means of communication and entertainment are certainly familiar with the term meme. A meme phenomenon popular is the use of the word 'tenggelamkan' at the end of the discourse popularized by Susi Pudjiastuti, the former minister of fisheries and maritime affairs. The objectives of this study are as follows: (1) to determine the language style used in memes that use the word ‘tenggelamkan’ and (2) to determine the implicature of memes using the word ‘tenggelamkan’. The data source of this research is taken from various pictures on the internet, amounting to 15 memes. The data collection used is the method capture. The research method is descriptive qualitative, the analysis used is Grice's theory of conversational maxims. The results of this study indicate the themes used in memes using the word ‘tenggelamkan’ include the themes of love, friendship, corruption, worship, and food. The use of language styles that are reflected, such as 9 memes of cynicism, 5 memes of paradox, and 1 meme of rhetoric. The implicatures of meme data using the word ‘tenggelamkan’ are as follows: satire, suggestion, satire and suggestion.
KİTLE KÜLTÜRÜ VE METALAŞAN SANAT
Authors: ARIKAN Hakan
Published: November 2020

Endüstri devrimi ve gelişen teknoloji ile birlikte küresel kitle kültürü, kendisini hissettirmeye başlamış ve dünyada meydana gelen hızlı değişmeler küçülen dünyanın tüm katmanlarını etkileyen bir yapıya dönüşmüştür. Kitle kültürü tartışmaları, beraberinde kültür sanat üzerinde de köklü değişimler yaratarak kendisini göstermiştir. Giderek artan üretim yöntemleri ve ilerleyen teknoloji, kapitalizmin ve onun sürekliliğini sağlayan dinamiklerin zaman içinde güçlenerek bir tüketim kültürü yaratmasına neden olmuştur. Fakat bu kültür, doğal koşullarda toplumun bünyesinden çıkan bir kültürün değil, kapitalist sermaye tarafından yaratılan yapay bir kültürün küresel olarak yaygınlaşmasına neden olmuştur. Üretilen bu yapay kitle kültürü sanat ürünlerinin metalaşmasından, yaşadığımız her yere kadar sızmış ve toplumu işgal etmiştir. Kitle kültürü aracılığı ile yaratılan sahte algılar, yapay tatlar, imajlar ve alanlarla sürekli üzerine gelinen birey, iktidarın isteği doğrultusunda soluk alıp veren, her an tahakküm mekanizmalarının işletildiği bir malzeme olarak iktidarın sürekliliğini sağlayan bir işlev yerine getirmektedir. Bu bağlamda, küreselleşen dünya ve modern sürecin geldiği noktada sanatçı da üretim ilişkilerinde artık yaşam içinde tutunabilmek için kurumsal yapı ve organizasyonlara boyun eğen, hayatını sürdürebilmek adına kültür endüstrisine entegre olmak zorunda bırakılmıştır.
A teoria das Inteligências Múltiplas contextualizada com Educação, Neurociência e Pensamento computacional: uma revisão de literatura
Authors: Quadros Carlos Eduardo Pereira de , Bicho Alessandro De Lima , Adamatti Diana Francisca
Published: November 2020

Este artigo apresenta uma revisão de literatura sobre a teoria das Inteligências Múltiplas (teoria das IM) e como a Educação, a Neurociência e o Pensamento computacional se correlacionam com esta teoria principal. Esta revisão é focada em trabalhos apresentados na última década (2010-2019). Os trabalhos foram selecionados através de palavras-chave em seis bases de dados acadêmicas. A maioria dos trabalhos relaciona as IM com Educação e, em seguida, com a Neurociência e, por último, com o Pensamento computacional. A principal ideia é buscar a inter-relação entre estas áreas e como elas podem ser trabalhadas conjuntamente, sendo foco para pesquisas futuras.
Expediente e Editorial
Authors: Gomes Raquel Salcedo , De Lima Valdeni
Published: November 2020

V. 23, n. 2, 2020
Resumos de Teses
Authors: Gomes Raquel Salcedo
Published: November 2020

V. 23, n. 2, 2020
Programação em Blocos: impacto de um projeto de extensão executado em Escolas públicas de Diamantina/MG
Authors: Batista Riann Martinelli , Horta Euler Guimarães , Fonseca Alexandre Ramos
Published: November 2020

O ensino da lógica de programação em escolas do Ensino Básico está consolidado em alguns países. No Brasil são poucas as iniciativas que facilitam o contato a este conteúdo na escola. Um projeto de extensão universitária foi criado visando a oferecer o primeiro contato com a lógica de programação a alunos da rede pública. No projeto, alunos da cidade de Diamantina/MG tiveram contato com ferramentas lúdicas de programação em blocos e de criação de aplicativos móveis. O intuito foi apresentar a base estrutural de algoritmos utilizando blocos, permitindo que os participantes expressassem sua criatividade, desenvolvendo aplicativos. A partir de dados coletados por meio de observação e de respostas a questionários, foi possível fazer um levantamento dos impactos deste tipo de conteúdo aplicado para estudantes da Educação Básica. Dentre alguns resultados destaca-se o aumento do interesse dos participantes em cursarem computação no futuro.
A cooperação arriscada: a gênese do envio da Missão Venturini (1983) ao Suriname sob a lente da Teoria Prospectiva
Authors: Silva Álvaro Vicente Costa
Published: November 2020

Este artigo analisa a motivação brasileira para agir como mediador de tensões em um dos momentos mais delicados da história do Suriname, em 1982: a crise que sucedeu o assassinato de diversos opositores de seu líder, Desiré Bouterse, que propugnava uma guinada na política externa de seu país, propondo uma aproximação de Cuba. A gestão brasileira ficou conhecida como “Missão Venturini”, enviada em 1983, cujo maior objetivo foi evitar essa guinada do governo surinamês, bem como potenciais ingerências dos Estados Unidos, que investiam em intensa campanha anticomunista sob o governo Ronald Reagan, na América do Sul. Nossa análise, pautada em documentos dos Arquivos Saraiva Guerreiro e Azeredo da Silveira, disponibilizados pelo CPDOC/FGV, usa a teoria prospectiva para oferecer uma resposta a tal indagação. Indicamos que a executiva de política externa, agindo de modo a evitar perdas decorrentes de possíveis gestões estadunidenses na região, optou pelo oferecimento de cooperação ao Suriname visando “moderar” o discurso e as ações do governo Bouterse.
Três performances para um país que luta com arte
Authors: Huerta Ricard
Published: November 2020

Durante o “II Seminário Internacional de Arte / Gênero / Ensino em Tempos de Conservadorismo”, realizado no Centro de Artes da Universidade Regional do Cariri - URCA (Crato, Brasil), pudemos assistir e participar de várias performances artísticas, atividade que dava início a cada dia do Seminário. Apresentamos aqui um ensaio visual baseado em três performances nas quais os artistas interagiram com as pessoas no espaço público: Tálamo, de Maria Macêdo (13/08/2019, 20:30, Plaza Cristo Rei, Crato); Bagagem, de Shambuyi Wetu, artista da República Democrática do Congo que vive atualmente em São Paulo, Brasil (15/08/2019, 8:30 da manhã, Praça Cristo Rei, Crato); e Super Zentai, de Rafael Bqueer, artista do Rio de Janeiro (16/08/2019, 21:30, Estação de Metrô Padre Cícero, Crato). O Seminário foi organizado por: Grupo de Pesquisa Ensino de Arte em Contextos Contemporâneos GPEACC / CNPq, Novos Ziriguiduns Internacionais e Nacionais Gerados em Artes Visuais NZINGA / CNPq e o Grupo de Pesquisa Ateliê de Pintura: oportunidades e descobertas de materiais pictóricos / CNPq. Agradecimentos especiais a Fábio José Rodrigues da Costa e Renata Aparecida Felinto dos Santos.
Artes do povo Xakriabá e a escola monoepistêmica: desafios metodológicos
Authors: Faria Tales Bedeschi , Silva Vanginei Leite
Published: November 2020

Doze anos após a promulgação da Lei nº 11.645/2008, há evidências de que o ensino das histórias e culturas dos povos indígenas no Brasil não vem sendo realizado nas escolas. Surgem perguntas: como a escola pode solicitar, ao professor, o ensino de uma história e uma cultura que ele nunca aprendeu? Como ensinar uma cultura de bases epistemológicas desconhecidas para a escola de tradição monoepistêmica? A partir de um diálogo entre um professor do povo Xakriabá e um professor não indígena, este artigo toca em pontos fundamentais, como as concepções de arte, cultura e educação, entre os Xakriabá, e como esse povo ensina e aprende suas artes.
Imagens híbridas: intersecções da fotografia com meios litográficos alternativos
Authors: Blauth Lurdi , Becker Amanda
Published: November 2020

Este estudo trata de uma produção de paisagens denominadas Inços realizadas a partir da fotografia digital e meios alternativos analógicos com o intuito de substituir materiais tradicionalmente utilizados na litografia. Apresenta alguns dos resultados obtidos pela gravação com refrigerante cola em chapas de offset descartadas pela indústria gráfica e suas possibilidades de reprodução da imagem. A metodologia trata da pesquisa em arte, que envolve os processos de criação e a testagem prática em ateliê, visando a utilização de materiais menos tóxicos, maiores cuidados com a saúde e o meio ambiente, bem como a reflexão teórica sobre a pesquisa realizada.
Ensino de artes visuais e artesania: experiências, confluências e derivas
Authors: Peixe Rita Inês Petrykowski , Hernández-Hernández Fernando , Prieto Villanueva Jesús-Ángel , Canônica Rosangela
Published: November 2020

Apresentação
The prevention and management of Frey's syndrome and a step by step guide through the nonsurgical treatment with Botulinum toxin
Authors: Fiedler Lukas S
Published: November 2020

Firstly described by Lucy Frey in 1923 the “Frey’s syndrome” is
characterized by sweating and flushing in direct response to
mastication. The mechanism is aberrant regeneration of postganglionic
parasympathetic neurons from the auriculotemporal nerve and
Acetylcholine secretion by a masticatory stimulus. This entity occurs in
up to 65% following lateral parotid resections and less commonly after
neck dissection or facelift procedures. This article aims to list
possible surgical and non-surgical treatment options of this iatrogenic
entity but should focus on the treatment with botulinum toxin A and
provide a step by step guide from the Lugol-Iodine-Starch test to the
botulinum toxin A (BoNTA-ONA) injection within the affected area.
Novel use of statistics to determine precise relationship assignment to estimate breeding output of a threatened amphibian with tadpole genotypes
Authors: Beranek Chad , Colyvas Kim , Clulow John , Mahony Michael
Published: November 2020

Relatedness (rxy) measures are useful in molecular ecology studies as
they can provide a means to answer biological hypotheses where pedigree
information is valuable. Our understanding of the reproductive ecology
of the threatened amphibian Litoria aurea is not complete where applying
rxy measurements may provide further elucidation. Here we use SNPs to
identify which rxy estimators (or combination of) most precisely assign
relationships in L. aurea tadpoles to determine how many breeding pairs
contribute to producing propagules in explosive breeding events. We
aimed to (1) use simulated L. aurea genotype data to determine the
precision of six rxy estimators, (2) compare the precision of
relationship assignment thresholds between rxy estimators computed by
discriminant function analysis (DFA) and test if using multiple
estimators improved precision, and (3) Apply the best performing DFA
model to assign relationships in wild tadpoles to quantify how many
mating pairs reproduced in explosive breeding events. We hypothesised
that each tadpole cohort produced during explosive breeding events would
be conceived by >|2| mating pairs. The
triadic maximum likelihood estimator had the highest Pearson’s R2 (0.92)
and the lowest amount of misclassifications in the DFA (16.00%). A
multi-variate DFA that included three rxy estimators further reduced the
misclassifications down to 11.88%. There was evidence that more than
one mating pair contributed to each explosive breeding event (n = 11).
We show that the multi-variate DFA enabled precise relationship
classification of free-living tadpoles which improved knowledge on
amphibian reproductive ecology. We recommend this method for
relationship assignments in SNP genotyped datasets.
Tracheal invasion and cardiopulmonary compromise from primary thyroid lymphoma
Authors: Fang S. , Hu Lisi , Kapoor Karan
Published: November 2020

Rapidly expanding thyroid lesions with tracheal invasion are typical
characteristics of anaplastic and high-grade thyroid carcinomas.
However, primary thyroid lymphoma (PTL) must also be considered as a
differential. We present a rare case of PTL with direct invasion and
compression of the trachea resulting in pulmonary oedema and
cardiomyopathy.
Comparison of C:N:P stoichiometry in the plant–litter–soil system between poplar and elm plantations in the Horqin Sandy Land, China
Authors: WANG KAI , Zhang Risheng , Song Lining , Yan Tao
Published: November 2020

Afforestation is among the most effective means of preventing and
controlling desertification. Silver poplar (Populus alba) is commonly
planted tree species for afforestation of the Horqin Sandy Land of
China. However, this species has exhibited some drawbacks such as top
shoot dieback, premature senescence and mortality, and soil and
ecosystems degradation. In contrast, Siberian elm (Ulmus pumila) rarely
experiences these problems in the same regions. Ecological stoichiometry
plays a vital role in exploring ecological processes and nutrient cycle
relationships in plant–litter–soil systems. We measured C, N, and P
concentrations in leaves, branches, roots, litter, and soils and
analyzed N and P resorption efficiencies, and stoichiometric homeostasis
in elm and poplar plantations in the Horqin Sandy Land. The results
showed that soil C and N concentrations, C:P, and N:P were greater in
the elm plantation than in the poplar plantation. The plant N
concentrations, C:P, and N:P and litter N and P concentrations were
greater, whereas N and P resorption efficiencies were lower, in the elm
plantation than in the poplar plantation. Generally, elm exhibited
greater homeostasis than poplar. These findings indicate that poplar
exhibited more developed internal nutrient conservation and allocation
strategies but poor nutrient accumulation in soil, which may contribute
to degradation of poplar plantation. In contrast, elm tended to return
more nutrients to the soil. Therefore, compared with poplar, elm may be
a more suitable afforestation tree species for the Horqin Sandy Land,
where it may promote the accumulation of soil nutrients and enhance
ecosystem stability.
Atorvastatin combined with or without dexamethasone for the treatment of chronic subdural hematoma in super-aged patients
Authors: Quan Wei , Yuan Jiangyuan , Liu Xuanhui , Li Pan , Huang Jinhao , Gong Zhitao , Gao Chuang , Luo Hongliang , Xiang Tangtang , Wang Dong , An Shuo , Wei Yingsheng , Sun Jian , Zhang Yongqiang , Wang Zengguang , Lei Ping , Deng Quanjun , Zhang Jianning , Jiang Rongcai
Published: November 2020

Aim：Chronic subdural hematoma (CSDH) is common in aged people, and
minimally invasive surgical interventions such as burr-hole-drainage and
twist-drill craniostomy are the first-line therapeutic options for this
condition. However, the mortality rate among super-aged patients (over
90 years of age) with CSDH is as high as 38.4% after these surgical
procedures. Atorvastatin alone or in combination with dexamethasone has
been proven to be effective in eliminating CSDH. In the current study,
the researchers evaluated the therapeutic efficacy of atorvastatin with
or without dexamethasone on the CSDH patients over 90 years.
Methods：The study attempted to treat 12 super-aged patients with
primary or post-operative relapsed CSDH by using atorvastatin alone or
in combination with dexamethasone. The changes in hematoma volume
measured with computed tomography (CT) or magnetic resonance imaging
(MRI) and the patients’ neurological improvement were monitored by
activities of daily living (ADL) and modified Rankin scale (MRS) scores.
Results：Treatment with atorvastatin or atorvastatin combined with
low-dose dexamethasone had beneficial effects on hematoma elimination
and/or symptom remission within 6 to 24 weeks in 12 super-aged patients.
All of them showed complete recovery after 1~4 years of
follow-up. Conclusion：The findings in this study indicate that
atorvastatin with or without dexamethasone is safe and effective for the
treatment for CSDH in super-aged patients.
The Post-hunter-gatherer Era Microbes Hypothesis for Chronic Inflammatory Diseases
Authors: Waterhouse Joyce
Published: November 2020

This article proposes an extension of the hygiene hypothesis to explain
chronic inflammatory diseases (CIDs) and their increase with
westernization. Instead of emphasizing microbes that are missing/reduced
due to westernization, a hypothesis is proposed that emphasizes the
importance of microbes that are relatively novel. Environmental microbes
encountered in association with a pre-agricultural lifestyle would
presumably be the most coevolved with the human immune system and thus
less likely to promote chronic disease. Post-hunter-gatherer era
microbes (PHMs) are microbes that are encountered more frequently and/or
at higher levels since humans ceased to live as nomadic
hunter-gatherers. It is hypothesized that some PHMs, particularly those
increasing with westernization, colonize human tissues and
dysregulate/suppress the immune system. This hypothesized colonization
of PHMs could cause allergy/hypersensitivity reactions leading to
physiological stress, attacks on self-tissue, hypersensitivity reactions
to similar cross-reacting environmental microbes and other
allergens/antigens, greater vulnerability to diverse infections (e.g.,
COVID-19) and CIDs. Low-level colonization with diverse PHMs could
explain high levels of comorbidities among CIDs, allergic responses to
self-tissue (auto allergy), allergies to varied microbial taxa and
allergen-initiated stress effects. Allergic reactions and the stress
they cause might be adaptive by promoting expulsion and avoidance of
potentially dangerous microbes. This is consistent with the observation
that selective IgE deficiency leads to increased levels of diseases such
as asthma, chronic rhinosinusitis, otitis media and autoimmune disease.
PHMs that could be related to CIDs include microbes in tobacco smoke,
increased Candida albicans and Aspergillus fumigatus that occurs in some
situations, and increased exposure to Pseudomonas fluorescens and
Yersinia spp. Additionally, fungi that tolerate multiple extreme
environments have been found to be more likely to be opportunistic
pathogens. This might suggest that microbes associated with
human-created novel and extreme environments (e.g., antibiotics,
xenobiotics) would have an increased ability to colonize and persist in
humans. The PHM hypothesis could help explain contradictory findings on
diet, why many chronic inflammatory diseases resemble chronic infections
and why stress and xenobiotics are associated with CID incidence and
exacerbations. Four foundations and 11 related hypotheses are discussed.
Examples discussed include sarcoidosis, inflammatory bowel disease,
asthma, long-term COVID-19 and Kawasaki disease.
A Comparison of Quantum and Traditional Fourier Transform Computations
Authors: Musk Damian
Published: November 2020

The quantum Fourier transform (QFT) can calculate the Fourier transform of a vector of size N with time complexity 𝒪(log2N) as compared to the classical complexity of 𝒪(NlogN). However, if one wanted to measure the full output state, then the QFT complexity becomes 𝒪(Nlog2N), thus losing its apparent advantage, indicating that the advantage is fully exploited for algorithms when only a limited number of samples is required from the output vector, as is the case in many quantum algorithms. Moreover, the computational complexity worsens if one considers the complexity of constructing the initial state. In this paper, this issue is better illustrated by providing a concrete implementation of these algorithms and discussing their complexities as well as the complexity of the simulation of the QFT in MATLAB.
INDIRECT ULTRASOUND EVALUATION OF LEFT VENTRICULAR OUTFLOW TRACT DIAMETER IMPLICATIONS FOR HEART FAILURE AND AORTIC STENOSIS SEVERITY ASSESSMENT.
Authors: Pestelli Gabriele , Fiorencis Andrea , Pergola Valeria , Luisi Giovanni , Smarrazzo Vittorio , Trevisan Filippo , Mele Donato
Published: November 2020

Background. Whereas dependency of left ventricular outflow tract
diameter (LVOTD) from body surface area (BSA) has been established and a
BSA-based LVOTD formula has been derived, the relationship between LVOTD
and aortic root and LV dimensions has never been explored. This may have
implications for evaluation of LV output in heart failure (HF) and
aortic stenosis (AS) severity. Methods. A cohort of 540 HF patients who
underwent transthoracic echocardiography was divided in a derivation and
validation subgroup. In the derivation subgroup (N=340) independent
determinants of LVOTD were analyzed to derive a regression equation,
which was used for predicting LVOTD in the validation subgroup (N=200)
and compared with the BSA-derived formula. Results. LVOTD determinants
in the derivation subgroup were sinuses of Valsalva diameter (SVD,
beta=0.392, P<0.001), BSA (beta=0.229, P<0.001), LV
end-diastolic diameter (LVEDD, beta=0.145, P=0.001), and height
(beta=0.125, P=0.037). The regression equation for predicting LVOTD with
the aforementioned variables
(LVOTD=6.209+[0.201xSVD]+[1.802xBSA]+[0.03xLVEDD]+[0.025xHeight])
did not differ from (P=0.937) and was highly correlated with measured
LVOTD (R=0.739, P<0.001) in the validation group. Repeated
analysis with LV end-diastolic volume instead of LVEDD and/or accounting
for gender showed similar results, whereas BSA-derived LVOTD values were
different from measured LVOTD (P<0.001). Conclusion. Aortic
root and LV dimensions affect LVOTD independently from anthropometric
data and are included in a new comprehensive equation for predicting
LVOTD. This should improve evaluation of LV output in HF and severity of
AS, avoiding use of LVOT velocity-time integral alone, which can be
misleading, especially when LV cavity and aortic root dimensions are
abnormal.
Uncertain portfolio optimization problem with liquidity and diversification
Authors: Zhang Ranran , Li Bo
Published: November 2020

This paper deals with a portfolio selection problem with uncertain
returns. Here, the returns of the assets are regarded as uncertain
variables which are estimated by experienced experts. First, an
uncertain mean-variance-entropy model for portfolio selection problem is
presented by taking into account four criteria viz., return, risk,
liquidity and diversification degree of portfolio. In the proposed
model, the investment return is quantified by uncertain expected value,
the investment risk is characterized by uncertain variance and entropy
is used to measure the diversification degree of portfolio. Moreover,
different from the previous bi-objective optimization model, our model
achieves both the maximum return and the minimum risk in a single
objective form by introducing a risk aversion factor and the dimensional
influence caused by different units is eliminated by normalization.
Then, two auxiliary portfolio selection models are transformed into
different equivalent deterministic models. Finally, a numerical
simulation is given to verify the practicability of our model.
The effective Equations for the Ultrasonic Response of Wet Cortical Bone
Authors: Blaszczyk Mischa , Gilbert Robert , Hackl Klaus
Published: November 2020

We outline the mathematical model of the ultrasonic response of wet
cortical bone and its time harmonic formulation. We employ an energetic
approach based on the Reuss-bound of the free energy of a porous
material consisting of a piezo-electric solid and a conducting fluid
part. Magnetic effects are taken into consideration. Corresponding
boundary value problems are stated and associated theorems established.
A conclusion is included concerning future developments of this
formulation.} \keywords{wet bone, ultrasonic response,
Maxwell equations}
Ultra-radical surgery compared to standard surgical treatment for women with advanced ovarian cancer: a cost-effectiveness analysis
Authors: Bettoli Giovanna , Phillips Andrew , Sundar Sudha , Cummins Carole , Bali Anish
Published: November 2020

Objective To compare current surgical practice for women with AOC to
ultra-radical surgery; to assess whether the new approach would be
cost-effective under NICE guidelines of approximately £20,000/QALY.
Design Cost-effectiveness analysis. Setting NHS, using data from a
variety of sources. Population Patients with advanced ovarian cancer
(FIGO stages IIIC-IV). Methods A decision analytic model
(microsimulation model) was built to examine the Objective;
deterministic and probabilistic sensitivity analyses were used to test
the susceptibilities of the baseline model and its assumptions. Main
Outcome Measures ICER (incremental cost-effectiveness ratio). Results
The standard model yielded an ICER of £5325.06; this is in spite of an
associated overall decrease in utility due to predicted increase in
surgical mortality. The parameters with the most significant impact on
the ICER are the cost of ultra-radical surgery, the utility associated
with progression-free survival, and the probability of death from
ultra-radical surgery. Conclusions Ultra-radical surgery is
cost-effective under NICE willingness-to-pay thresholds of £20000; the
costs of ultra-radical surgery are bound to decrease as centres
specialise further, and its effectiveness is also likely due to increase
with development of newer techniques and more surgical training.
Franjo Tuđman i problemi objavljivanja knjige Nacionalno pitanje u suvremenoj Europi
Authors: Ćosić Mirko
Published: November 2020

Na temelju izvora iz fondova Hrvatskoga državnog arhiva, osobito dokumentacije koju je Služba državne sigurnosti Republičkog sekretarijata za unutrašnje poslove Socijalističke Republike Hrvatske prikupila o Bogdanu Radici i Franji Tuđmanu te korespondencije tih dvaju
intelektualaca koju je ta služba nadzirala, autor u radu iznosi okolnosti inicijative tiskanja Tuđmanove knjige Nacionalno pitanje u suvremenoj Europi
u inozemstvu. Naime, nakon kaznenih progona 1972. i 1981. Tuđman je prisilno udaljen iz društvenoga života, pritiješnjen stvarnošću jugounitarizma. Odvažni napor tiskanja knjige, usprkos svim prijetnjama,
prerastao je u pokušaj njegova izlaska iz nametnute izolacije koja je trajala sve do 1988., kada je primljen u Društvo književnika Hrvatske, nakon čega počinje nastupati na javnim tribinama te 1989. objavljuje i knjigu Bespuća povijesne zbiljnosti.