bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring myocardial fibrosis in severe aortic stenosis: echo, CMR and histology data from FIB-AS study
Authors: Balčiūnaitė Giedrė , Besusparis Justinas , Palionis Darius , Žurauskas Edvardas , Skorniakov Viktor , Janušauskas Vilius , Zorinas Aleksejus , Zaremba Tomas , Valevičienė Nomeda , Šerpytis Pranas , Aidietis Audrius , Ručinskas Kęstutis , Sogaard Peter , Glaveckaitė Sigita
Published: December 2021

PurposeMyocardial fibrosis in aortic stenosis (AS) is associated with worse survival following aortic valve replacement (AVR). We assessed myocardial fibrosis in severe AS patients, integrating echocardiographic, cardiovascular magnetic resonance (CMR) and histological data. MethodsA total of 83 severe AS patients (age 66.4 ± 8.3, 42% male) who were scheduled for surgical AVR underwent CMR with late gadolinium enhancement (LGE) and T1 mapping and global longitudinal strain (GLS) analysis. Collagen volume fraction (CVF) was measured in myocardial biopsies (71) that were sampled at the time of AVR. ResultsCVF correlated with imaging and serum biomarkers of LV systolic dysfunction and left side chamber enlargement and was higher in the sub-endocardium compared with midmyocardium (p<0.001). CVF median values were higher in LGE-positive versus LGE-negative patients [28.7% (19-33) vs 20.7% (15-30), respectively, p=0.040]. GLS was associated with invasively (CVF; r=-0.303, p=0.013) and non-invasively (native T1; r=-0.321, p<0.05) measured myocardial fibrosis. GLS and native T1 correlated with parameters of adverse LV remodelling, systolic and diastolic dysfunction and serum biomarkers of heart failure and myocardial injury. ConclusionOur data highlight the role of myocardial fibrosis in adverse cardiac remodelling in AS. GLS has potential as a surrogate marker of myocardial fibrosis, and high native T1 and low GLS values differentiated patients with more advanced cardiac remodelling.
A Wearable Low-cost Muscle Activated Switch for Wireless Control for the Physically Challenged Patients
Authors: Iqbal A.
Published: December 2021

BackgroundTo control the environmental conditions of the living place and to use the electrical appliances and computers etc. are one of the major challenges for the physically disabled persons and elderly people. The surface electro myography (sEMG) is employed to detect the muscle movement and used for games therapy and various others applications. This paper presents a low-cost wearable muscle switch designed to acquire sEMG signal and process it to provides the control, gaming therapy and mode of communication to the physically disabled patients.ResultsThis paper proposes a wearable low-cost muscle activated switch to assist the physically challenged members of the society. The designed muscle activated switch consists of Myoware muscle sensors that is used for data acquisition and to detect the muscle activity from the target muscle using Electromyography (EMG) signals. The Arduino board provides the human-computer interface and control to the devices based on the muscle signal. The Bluesmirf bluetooth is used for the wireless connectivity to our designed system that assists the physically disabled persons to use the computer and to control the home appliances via commercially available Grid 3 software and wifi switches. The novelty of this muscle sensor switch is that it can be connected to any bluetooth compatible devices that can be controlled from any targeted muscle. The system was tested with Grid 3 software on laptop for environmental control and text to speech conversion.ConclusionsA low cost muscle sensor based Bluetooth switch system for the physically disabled patients has been presented in this paper. The designed switch can be connected to any Bluetooth enabled device as demonstrated in this paper. The physically disable persons can select any module from the Grid 3 software such as the environmental control (to control the environment via electrical appliances), text to speech converter (for Aphasia patients), gaming therapy etc. The designed system can also be utilized to use the Bluetooth enabled electric gadgets such as Mobile Phones, Ipad and android Tablets etc. in accessibility mode.
Performance of 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus in Children and Adults : A Retrospective Observational Study
Authors: Cheng Sang , Ding Huihua , Xue Haiyan , Xia Min , Tu Zhiqiang , Zhang Weiqi , Cao Lanfang
Published: December 2021

Background: The European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) recently developed a systemic lupus erythematosus (SLE) classification criteria (EULAR/ACR-2019) with high sensitivity and specificity. The aim of this study was to validate and compare the performance of the newly developed criteria to that of the ACR-1997 and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-2012) criteria in juvenile-onset SLE (jSLE) and adult-onset SLE (aSLE) patients.Methods: We conducted a retrospective study of SLE patients (221 children and adult) and controls (214 children and adult) with defined rheumatic diseases to establish the ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria. The performance of the three criteria was statistically analyzed.Results: For jSLE, sensitivities of ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria were 63.3%, 94.6% and 98.2% (P < 0.001), with specificities 99.5%, 98.6% and 93.5% (P < 0.001), respectively. For aSLE, sensitivities of ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria were 72.9%, 96.8% and 99.1% (P < 0.001), with specificities 97.2%, 92.5% and 90.2% (P = 0.013), respectively. In ANA positive juvenile patients, a EULAR/ACR score ≥13 instead of a score ≥10 resulted in higher specificity (93.1% vs. 75.9%), despite slightly lower sensitivity (92.2% vs. 99.5%). In both jSLE and aSLE patients, the SLICC-2012 and EULAR/ACR-2019 criteria had increased sensitivity for major organ involvement than ACR-1997.Conclusion: The EULAR/ACR-2019 criteria showed similar sensitivity to jSLE and aSLE patients and was more sensitive than ACR-1997 and SLICC-2012 criteria, allowing earlier recognition of patients with single or major organ involvement. The adoption of a EULAR/ACR total score ≥13 in this study, instead of the initially proposed ≥10 score, was more appropriate to classify jSLE.
Living with FGM: Improving Knowledge and Skills of Health Care Providers in Iraqi Kurdistan
Authors: Mahmoudi Osman
Published: December 2021

Background: Despite the high prevalence of female genital mutilation in many settings and the health consequences associated with it, many healthcare providers have limited knowledge of female genital mutilation and limited skills for preventing and managing related complications. With Knowledge of this Important matter aim of this study is to determine the effectiveness of TOT workshops on the knowledge and skills of social workers working with girls and women affected by FGM.Methods: To demonstrate the findings, a quasi-experimental study was conducted with a pre and post-assessment. There were 44 participants who worked with FGM victims across Iraqi Kurdistan. Socio-demographic details of the participants who have collected knowledge on psychosexual and physical care, psychosexual skills, and referral programs were assessed using a continuum scale of 0 to 4. Descriptive and inferential statistics were carried out for the analysis.Results: The results showed that participants' knowledge and skills improved in relation to psychosexual and physical care for girls and women living with FGM and referral programs for them. The paired sample t-test carried showed a significant increase in knowledge among participants in psychosexual and physical care for girls and women living with FGM (f=9.25, df=1, P=.001), Psychosexual skills (f=-8.20, df=1, P=.001), and FGM victims referral Programs (t=12.95, df=1, P=.001). Follow-up test also showed that these changes were constant from post-test to follow-up.Conclusions: Preparing the social workers on the integration of physical and psychosocial care for girls and women living with FGM in their existing activities would equip them in providing holistic care for them in addressing the emerging psychosexual problems.
Mesoporous ZnO@Co3O4 Nanosphere for Sensitive Detection of 3-Hydroxy-2-Butanone
Authors: Tian Xinxin , Yin Ming , Zhang Li , Qiu Tianyi , Xu Dongpo , Qiu Jingxuan
Published: December 2021

The mixed semiconductor metal oxides as the gas sensor can enhance the sensitivity compared with the metal oxide respectively. In this study, the mesoporous ZnO@Co3O4 nanosphere was prepared through the simple hydrothermal synthesis method of ZIF-L-Zn@Co, the cage construction of mesoporous ZnO@Co3O4 nanosphere was remained unchanged after the calcination of the ZIF-L-Zn@Co at 600℃ for 2 h in the air. The mesoporous ZnO@Co3O4 nanosphere was selected as the gas sensor for the detection of 3-Hydroxy-2-Butanone. Compared with the ZnO and Co3O4 respectively, the mesoporous ZnO@Co3O4 nanosphere as the gas sensor shows the high sensitivity, selectivity and stability.
Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Findings of Differential Gene Expression Analysis of Oocytes
Authors: Nakanishi Natsuki , Osuka Satoko , Kono Tomohiro , Kobayashi Hisato , Ikeda Shinya , Bayasula Bayasula , Seki Tomomi , Yabuki Atsushi , Tanaka Hideaki , Sonehara Reina , Murakami Mayuko , Yoshita Sayako , Miyake Natsuki , Muraoka Ayako , Kasahara Yukiyo , Murase Tomohiko , Nakamura Tomoko , Goto Maki , Iwase Akira , Kajiyama Hiroaki
Published: December 2021

Background: Polycystic ovary syndrome (PCOS), a common endocrinal disorder, is associated with impaired oocyte development, which leads to infertility. However, the pathogenesis of PCOS has not been completely elucidated. Limited studies have analyzed the pathological characteristics of oocytes in PCOS. This study aimed to analyze the differentially expressed genes (DEGs) and epigenetic changes in the oocytes of the PCOS mouse model to identify the etiological factors.Methods: C57BL/6J female mice were subcutaneously injected with vehicle or 5α-dihydrotestosterone (250 µg/day) on days 16–18 of pregnancy. Female offspring were used as the control or PCOS group. The oocytes were collected from mice aged 7–9 weeks. The DEGs between the control and PCOS groups were analyzed using RNA sequencing (RNA-Seq). Additionally, the DNA methylation status was analyzed using the post-bisulfite adaptor tagging method. The ovarian tissue sections were stained with hematoxylin and eosin to examine the morphological changes. The proteins, Rps21 and Rpl36, were measured using immunostaining.Results: Compared with the control group, the PCOS group exhibited impaired estrous cycle and polycystic ovary-like morphology. RNA-Seq analysis revealed that 90 DEGs were upregulated and 27 DEGs were downregulated in the PCOS mouse model. DNA methylation analysis revealed 30 hypomethylated and 10 hypermethylated regions in the PCOS group. However, the DNA methylation status was not correlated with differential gene expression. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that five DEGs (Rps21, Rpl36, Rpl36a, Rpl37a, and Rpl22l1) were enriched in ribosome-related pathways. The immunohistochemical analysis revealed that the expression levels of Rps21 and Rpl36 were significantly upregulated in the PCOS mouse model.Conclusions: These results suggest that differential gene expression in the oocytes of the PCOS mouse model is related to impaired folliculogenesis. These findings improved our understanding of the pathogenesis of PCOS.
Gas Transport Characteristics of Mixed Matrix Membrane Containing MIL-100 (Fe) Metal-Organic Frameworks and PEBAX Precursors
Authors: Pirouzfar Vahid , Roustaie Narges , Salimi Mahmoud , Su Chia-Hung
Published: December 2021

In this research, the effect of adding MIL-100 (Fe) MOFs on the PEBAX membranes has been scrutinized in two grades of 1657 and 2533. Initially, the intended membranes were synthesized by the solution-casting method. Then, the XRD and SEM were applied to deliberate the influence of adding MIL-100 (Fe) to the structure of both types of membranes. In consequence, the separation function of the pair gases of CO2/CH4، CO2/N2 and CO2/O2 and their permeability were considered at the pressure of 3.5 bar and temperature of 25°C. Eventually, their function was compared by Robeson diagrams of 1991 and 2008. The comparison results by Robeson diagrams indicated that the PEBAX1657/MIL-100 (Fe) and PEBAX2533/MIL-100 (Fe) membranes containing 5 wt.% of MOF represent more suitable performance in separating CO2/CH4 in comparison with the axis of the Robeson diagram. However, their function for separating the aforementioned gases requires more modifications.
WITHDRAWN: Frontotemporal Dementia: A systematic review
Authors: Khalifa Samar
Published: December 2021

Background:
Frontotemporal dementia is a common type of dementia and is a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins. The review is identifying the clinical measures including neuropsychological scores and functional measures.
Methods:
A systematic review was conducted covering the clinical trials done to investigate the Frontotemporal Dementia. The sample was taken from Pubmed library. 28 results were found in a range of time from 2016 to 2021. The excluded papers were 17.
Results:
A total of 10,349 articles were identified at the first stage of papers selecting. All records were screened in order to include and exclude by title/abstract and then based on full text. After excluding articles by year and type of papers, a total of 28 articles were identified through the databases. Following this, the irrelevant papers from databases were removed from original articles, and finally 11 articles were included based on their title/abstract. Full articles were then sourced for about 600 references. It included 732 patients and 195 controls as a total.
Conclusions:
The review describes the clinical and RCT trials for FTD in the last five years so it can be very updated information for the researchers to cover information required for their researches in the future ones.
Feed forensic strategy: Incorporating multivariate data analysis with high-performance liquid chromatography refractive index detector and differential scanning calorimeter for authentication of fish feed sources
Authors: Idris Mohamed Haniff Hanafy , Sani Muhamad Shirwan Abdullah , Hashim Amalia Mohd , Zaki Nor Nadiha Mohd , Manaf Yanty Noorzianna Abdul , Desa Mohd Nasir Mohd , Arshad Syariena , Yuswan Mohd Hafis , Hassan Mohd Sukri , Yusof Yus Aniza , Kamaruddin Mohd Salleh , Mustafa Shuhaimi
Published: December 2021

This study authenticated fish feed sources and determined lard adulteration using dataset pre-processing, principal component analysis (PCA), discriminant analysis (DA) and partial least square regression (PLSR) on 19 triacylglycerols (TAGs) and 16 thermal properties (TPs). At cumulative variability (90.625%) and Keiser-Meyer Olkin (KMO) value (0.811), the PCA identified strong factor loading variables, i.e., OLL, PLL, OOL, POL, PPL, POO, PPO, PSO, ICT and FHT in PC1 and LLLn, OOO and CT2 in PC2. These variables were significantly (p < 0.05) contributing to lard-palm-oil (L-PO) clusters: (1) POO, PPO and PPL (high loading) and OLL, PLL, OOL, ICT, POL, PSO and FHT (low loading) in 0:100 and 25:75 L-PO clusters; (2) CT2, OOO and LLLn (high loading) in 50:50 L-PO cluster; and (3) OLL, PLL, OOL, ICT, POL, PSO and FHT (high loading) and POO, PPO and PPL (low loading) in 72:25 and 100:0 L-PO clusters. Training, validation and testing datasets had 100%, 84.44% and 100% correct-classification, respectively at p < 0.0001 of Wilks' lambda and p < 0.0001 Fisher distance. The DA selected PLL, OOL, POL, PPL, PSO, ICT and FHT as the significantly authenticating biomarkers (p < 0.05). With determination coefficient (R²) (0.9693), mean square error (MSE) (38.382) and root mean square error (RMSE) (6.195), the PLSR's variable importance in the projection (VIP) identified the most influential biomarkers, i.e., PPL, POL, PPO, OOL, ICT, PLL, FHT, POO and OLL. The Z-test result (p > 0.05) indicated that the PLSR could determine the lard adulteration percentage in fish feed.
First-principles calculations of high-pressure physical properties anisotropy for magnesite
Authors: Liu Zi-Jiang , Sun Xiao-Wei , Zhang Cai-Rong , Zhang Shun-Jing , Zhang Zheng-Rong , Jin Neng-Zhi
Published: December 2021

The first-principles calculations based on density functional theory with projector-augmented wave are used to study the anisotropy of elastic modulus, mechanical hardness, minimum thermal conductivity, acoustic velocity and thermal expansion of magnesite(MgCO3) under deep mantle pressure. The calculation results of the phase transition pressure, equation of state, elastic constants, elastic moduli, elastic wave velocities and thermal expansion coefficient are consistent with those determined experimentally. The research results show that the elastic moduli have strong anisotropy, the mechanical hardness gradually softens with increasing pressure, the conduction velocity of heat in the [100] direction is faster than that in the [001] direction, the plane wave velocity anisotropy first increases and then gradually decreases with increasing pressure, and the shear wave velocity anisotropy increases with the increase of pressure, the thermal expansion in the [100] direction is greater than that in the [001] direction. The research results are of great significance to people's understanding of the high-pressure physical properties of carbonates in the deep mantle.
Distinct functions of genome-wide chromatin remodeling in the differentiation of T helper Type 1 and 2 cells
Authors: Zeng Wei-ping
Published: December 2021

T helper type 1 and 2 (Th1 and Th2) cells play critical roles in infectious, autoimmune and allergic diseases. Here we mapped genome-wide distribution of DNase I hypersensitive (DHS) sites in Th1, Th2 and their precursors naïve CD4 T cells. DHS sites were found unevenly distributed in the genomes with highest densities within 2kb of the transcription start sites (TSS). At the whole genome level, the DHS values, representing chromatin openness, but not the numbers of DHS sites showed strong positive correlation with gene expression. Th1 and Th2 differentiations were accompanied by changes of genome-wide distribution of DHS sites. The differentiated cells assumed more open chromatin structures than their precursors. During Th1 differentiation changes of DHS values could be statistically positively or negatively associated with changes of gene expression depending on the locations of the DHS sites, whereas only positive association was found during Th2 differentiation.
Machine Learning Based User Retention and Channel Allocation: 6G Aspect
Authors: Singh Pushpa , Agrawal Rajeev , Singh Krishan Kant
Published: December 2021

Future 6G wireless network will be focused on Artificial Intelligence (AI) based network selection, resource allocation and user satisfaction. A user has multiple options to switch one service provider to another service provider in case of network quality degradation. The new schemes/policies are required to retain their valuable users. This paper proposed supervised machine learning methods such as Decision Tree, K-Nearest Neighbor (KNN), Support Vector Machine (SVM), etc., to classify and identify the loyal user. The decision tree algorithm has been identified as the best classification technique in order to identify the type of user (loyal, normal, and recent). A threshold-based algorithm is proposed to allocate the resource, particularly to loyal users. The performance of the algorithm is measured in terms of average waiting time (AWT), and the number of particular types of user’s services dropped. Priority is given to the loyal user when only 10% network resource is available. The simulation environment is created by SimPy implemented in Python. The result of the simulation run represents that no loyal user’ services have been interrupted during communication. Loyal users achieved less AWT as 32.51s compare to the normal user and recent user.
Multidisciplinary treatment from infancy to adolescence of a patient with a unilateral cleft lip and palate: a 16-year follow-up case report
Authors: Ozturk Taner , Yagci Filiz , Yagci Ahmet
Published: December 2021

Cleft lip and palate (CLP) are conditions that require long-term management and review from infancy to adolescence. Surgical procedures become easier when nasoalveolar moulding (NAM) measures are applied during the neonatal period. Orthodontic treatment provided for these patients during the progressive dentition developmental periods can achieve positive aesthetic and functional results. In patients affected by a CLP, the lateral incisor in the cleft region is usually missing and multidisciplinary prosthodontic rehabilitation of the edentulous space is often required. In the present case report, positive results of NAM, coupled with orthodontic and prosthodontic treatment are presented for a CLP patient who began management during the neonatal period. In addition, a minimally invasive aesthetic restoration is presented as a solution for the prosthodontic rehabilitation of a missing lateral incisor.
James Clarence Mangan’ın Sûfîlerin Mânisi Başlıklı Şiirinin Kur’an-ı Kerim ve Sufîlik Bağlamında Metinlerarası Bir İncelemesi
Authors: ARIKAN Arda , UZUN Kıvılcım
Published: December 2021

James Clarence Mangan (1803-1849) Orta Doğu’nun kültürel ve sosyal atmosferini
edebi eserlerine konu etmiştir. Bir kısmının çeviri olduğunu iddia ettiği şiirlerin yanı sıra
tamamıyla kendisine ait olan şiirler de mevcuttur. Spiritüalizm ve mistisizme olan ilgisi
sonucu Mangan, Orta Doğu merkezli kadim bir inanış olan ve Batı dünyasında sıklıkla İslam
mistisizmi olarak adlandırılan Sûfîlik ile de özellikle ilgilenmişti. Aynı zamanda büyük Sûfî
öğreticilerinin edebi külliyatına hakimdi ve Sûfî öğretilerini kendi ürettiği metinlerde de
kullanmıştı. Bu metinlerden biri olan Sûfîlerin Mânisi isimli şiiri, yedi bölüme ayrılmasıyla ve
her bölümün kendi içerisinde yarı düzyazı yarı şiir biçiminde sunulmasıyla özellikle dikkat
çekicidir. Düzyazı kısımları her seferinde “besmele” ile başlayan şiirin hem içerik hem biçem
açısından incelenmeye ve metinlerarası bir okumaya ihtiyaç duyduğu gözlemlenmiştir. Bu
çalışmada, metinlerarasılık bağlamında yürütülen inceleme sonucu şairin yedi bölüme
ayırarak her bir bent öncesi verdiği düzyazıların Kur’an’ı Kerim’in belli başlı ayetlerine
yapılmış birer anıştırma olduğu sonucuna varılmıştır.
Yasa Koyucular ile Yorumcular
Authors: AYDIN İlhami
Published: December 2021

Modernite ve post-modernite dönemlerine yönelik geniş bir literatürden söz etmek
mümkündür. Literatür, genel olarak toplumların deneyimlediği gerçekliklere ve sorun
alanlarına yöneliktir. Aydınlanma, devrim tecrübesi, ulus-devlet, bireyselleşme,
sömürgecilik gibi gerçeklik ve sorun alanları örnek gösterilebilir. Her örnek, küresel etkilere
sahip olması hasebi ile akademik anlamda bitimsiz bir ilgiye mashar olmuştur. Bu ilginin
öznelerinden biri de Bauman’dır. Yazar, modern ve post-modern dönemleri tarif eden
tecrübeleri, somut bir nedene bağlayarak açıklama amacını gütmüştür. Özellikle ulus-devlet
gibi küre genelinde başat bir gücün, nasıl ortaya çıktığını ve evrildiğini betimlemiştir. Bu
bağlamda akıl ve bilimi esas alan cemaat olarak yasa koyucu erkin önce ulus-devleti bütün
mekanizmaları inşa etmesi ve sonrasında bu mekanizma karşısında gücünden
arındırılmasını, yani yorumlayıcı olmanın ötesinde işlevi olmayan cemaatin dönüşümü
resmetmiştir. Esasında kitapta, modern ve post modern dönemlerde entelektüel sınıf ile
devlet iktidarı arasındaki ilişkinin dünü ve bugününe dair farklılaşmayı konu edinmiştir.
Çalışmayı değerli kılan taraf ise, ulus-devlet yapısından doğan olumsuz yönlerin,
entelektüeller marifeti ile neden düzeltilemeği, bu arızi yönlerin yine söz konusu yapı
tarafından neden ve nasıl yeniden yorumlandığıdır. Hemen her sorun alanına dair son
derece girişken olan aydınların, modern devlet örgütlenmesi karşısında pasif duruşları
merak konusudur. Çalışma, bu yönü ile niteliğini korumakta ve dolayısıyla ona karşı
akademik ilgi canlı tutulmalıdır.
Filmes no ensino das Relações Internacionais
Authors: Koehler Zanella Cristine , Neves Junior Edson José
Published: December 2021

A partir de uma pesquisa quantitativa e qualitativa, com participação voluntária e nãoidentificada dos respondentes, este trabalho investiga o uso dos filmes como ferramenta pedagógica no ensino das Relações Internacionais no Brasil. Mapeamos quando os filmes são utilizados e por que, a percepção sobre o sucesso das atividades e as dificuldades observadas. Os dados confirmam que filmes são largamente utilizados; que as intenções principais ao utilizá-los são fornecer informações sobre eventos e ilustrar as explicações de dada teoria ou escola; e que os limites dessa ferramenta vão desde a falta de filmes apropriados à ausência de recursos adequados para exibição.
Impact of subclinical inflammatory markers on the development of cardiovascular pathology in patients with the metabolic syndrome
Authors: Belousova Oksana N. , Chupakha Marina V.
Published: December 2021

Metabolic syndrome currently remains one of the most pressing problems in medicine, since it makes its decisive contribution to the development of cardiovascular diseases and cerebral complications. Another important problem of modern medicine is arterial hypertension, which is one of the constituent criteria of metabolic syndrome, whose mechanism of development is due to a disruption in the work of the renin-angiotensin-aldosterone system, the sympathoadrenal system, an increased content of pro-inflammatory cytokines, as well as an imbalance in the adipokine system. Adipose tissue now acts not just as a structure that provides our body with energy only, but now it acts as an organ of the endocrine system, producing a large number of metabolically active substances. Patients with metabolic syndrome have been found to have elevated levels of proinflammatory cytokines were increased: monocytic chemotactic protein-1 (MCP-1), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). These cytokines are thought to be synthesised by adipose tissue macrophages and are involved in the pathogenesis of the metabolic syndrome. Oxidative stress can induce insulin resistance in adipocytes. The pathogenesis of oxidative stress in adipocytes in MS is still a mystery. This knowledge would be very useful in developing new approaches to MS therapy. Given the significant effect of chemokines in MS on the development of systemic inflammation, insulin resistance, and arterial hypertension, scientists have an important task not only to describe the actions of individual chemokines in hypertension, but also to characterize how the effect on one chemokine modulates the expression and/or function of other chemokines and their related receptors.
Um quase eterno reencontro
Authors: Ricarte Rafael , Rossy Leal Carvalho Rômulo
Published: December 2021

O presente artigo depreende uma análise do transcurso da participação de nativos no processo da Assembleia Nacional Constituinte (1987-1988) – em especial Ailton Krenak, da comunidade Krenak. Observamos a construção de discursos em torno da participação de nativos no período, e como a categoria indígena foi apresentada ao público mediante as diretrizes de uma nova constituição para o país através da primeira edição do Jornal da Constituinte (1987). Dialogamos com os pesquisadores Maria Regina Celestino de Almeida (2010), Miguel Alberto Bartolomé (2006), Christian Teófilo da Silva (2015). Nossas reflexões permitiram perceber uma dinâmica, por parte de Krenak, sobre alteridade, no contexto de uma participação à qual são dedicadas poucas linhas na primeira edição do periódico da Constituinte.
SEQUÊNCIA DIDÁTICA DO GÊNERO DISCURSIVO CONTO NO ENSINO FUNDAMENTAL: RELATO DE EXPERIÊNCIA
Authors: De Oliveira Ana Beatriz Albuquerque Peres , Silva Carla Duarte da Costa , Iliovitz Erica Reviglio
Published: December 2021

Este artigo tem o objetivo de apresentar uma sequência didática do gênero discursivo conto que foi aplicada em uma turma do 7º Ano do Ensino Fundamental em uma escola estadual no município de Natal/RN. A sequência didática durou doze aulas de 50 minutos e foi desenvolvida em seis etapas. Uma primeira abordagem ao gênero foi feita através da leitura. A sequência didática foi concluída com a produção escrita de um conto e uma autoavaliação. Ela também incluiu o estudo da biografia do autor e uma abordagem das principais características do gênero, tais como a análise de operadores de coesão temporal que contribuem para a tessitura do texto narrativo. Os resultados indicaram que a sequência foi bem sucedida, pois auxiliou os estudantes a compreenderem melhor as características do gênero discursivo conto.
Popularidade entre os jovens brasileiros do “jogo do Suicídio”: Baleia Azul e sua aceitação
Authors: Peixoto Kamila Joyce Lucas
Published: December 2021

O presente artigo discorre sobre a popularidade no Brasil de um jogo viral conhecido pelo nome Baleia azul ou Blue Whale. Descrito pela primeira vez na Rússia o jogo ganha popularidade e cada vez mais está atingindo jovens. Apesar de as únicas provas que existem contra ele ainda sejam as mortes similares e os relatos de mães sobre os comportamentos, também parecidos, antes da morte. O jogo já ganhou adeptos no Brasil, dentre as 862 pessoas que responderam ao questionário, em um dia, 14 pessoas afirmam jogar. Dentre os jogadores 90% são mulheres e em sua maioria não chegaram aos 18 anos de idade, a maior parte justifica para a entrada no jogo por decorrência da sua vida social.
A FITOTERAPIA NO CONTEXTO DA ATENÇÃO BÁSICA
Authors: Costa Josefa Waldenora da , Ferreira Karla Cristina Marques Afonso , Moutinho Nathanny Ferreira , Bezerra Thiago da Silva , Nunes Vilani Medeiros de Araújo
Published: December 2021

Objetivo: Avaliar o uso de plantas medicinais e o nível de conhecimento sobre fitoterapia por gestores e gerentes das Unidades de Saúde da Família (USF), bem como dos profissionais das equipes da Estratégia deSaúde da Família e da comunidade assistida por essas equipes. Metodologia: Estudo descritivo com abordagem quantitativa realizadoem Parnamirim, RN. Foram entrevistados 596 usuários em seis USF, 08 gestores/gerentes dos serviços e 123 profissionais da saúde, entre julho e setembro de 2016. Resultados: Falta de coerência entre a espécie da planta citada pelos usuários e a doença tratada com as indicações encontradas na literatura. Entre os profissionais, 60,2% referem pouco conhecimento sobre fitoterapia, 91,9% dos gestores desconhece a Política Nacional de Plantas Medicinais e Fitoterápicos, embora 50,4% já tenham indicado tratamento à base de plantas medicinais. Conclusão: Verificou-se que grande desafio na consolidação do uso de Plantas  edicinais e Fitoterápicos na qualificação dos profissionais.
Educação para a sustentabilidade, educação em ciências, formação e desenvolvimento de professores de ciências
Authors: Pedrosa Maria Arminda
Published: December 2021

O artigo Educação para a sustentabilidade, educação em ciências, formação e desenvolvimento de professores de ciências da professora da Universidade de Coimbra Maria Arminda Pedrosa aborda o conhecimento no âmbito da ciência da sustentabilidade (CS) e destaca a necessidade, urgência e importância de integrar a educação para sustentabilidade na educação científica em qualquer nível educativo. A autora aponta, ainda, desafios inerentes à integração da educação para sustentabilidade e abordagens destes problemas em educação em ciências.
Systemic Treatments for Adult Patients with Moderate-to-Severe Psoriasis:
Consensus Statements for the United Arab Emirates
Authors: Hammadi Anwar Al , Murrawi Muna Al , Ali Huda R. , Reda Ashraf M. , Dayem Hussein A. , Alnaqbi Jawaher , Abdelhadi Zaidoon , Hantirah Samir , Alnaeem Ayman , Marzooqi Fatima Al. , Alfalasi Amani , Albreiki Fatima , Aljefri Khadija , Ali Faiza Al
Published: December 2021

Background:

Psoriasis is a chronic, immune-mediated disease characterized by mild localized plaques to severe plaques involving any part of the skin; it has a
pronounced effect on patients’ quality of life. In the United Arab Emirates (UAE), there are limited local guidelines for the management of patients
with psoriasis in daily clinical practice.

Objectives:

The study aimed to develop consensus statements for the evaluation and management of moderate-to-severe psoriasis in the UAE.

Methods:

To develop consensus statements, the Emirates Dermatology Society set up advisory board meetings in which local key opinion leaders (KOLs),
including dermatologists from the UAE, participated. A targeted literature review was conducted to review current international and regional
guidelines on the management of psoriasis, based on which the statements were formulated. A final consensus on each statement was reached
based on collective agreement among the KOLs.

Results :

Consensus statements were generated with the intention of supporting physicians in clinical decision-making with respect to the classification of
disease severity, treatment options including biologic and non-biologic systemic therapies, transitioning and adjusting of systemic therapies, and
monitoring and management of psoriasis in special populations.

Conclusion:

These consensus statements could provide useful, practical guidance on the diagnosis and management of patients with moderate-to-severe
psoriasis and would cater to the needs of physicians in the UAE.
Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study
Authors: Ramzan Faiqah , Qureshi Irfan Zia , Ramzan Muhammad Haris
Published: December 2021

Background:

The discovery of kisspeptin signaling as a key regulator of gonadotropin-
releasing hormone (GnRH) secretion from the hypothalamus enhanced our understanding
of the neuroendocrine regulation of mammalian reproduction. Effects of central and peripheral administration
of kisspeptin on plasma gonadotropins, testosterone, and spermatogenesis are studied
in detail.

Objective:

The present study was conducted to check the ultrastructure of Leydig cells in prepubertal
male rats in response to the administration of a range of kisspeptin doses.

Method:

We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally
to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours. Control rats
were injected with physiological saline in parallel.

Results:

At the end of the treatment, plasma concentrations of testosterone were measured by competitive
binding radioimmunoassay, and small pieces of rat testicular tissue were processed for electron
microscopy to examine the ultrastructure of Leydig cells. Plasma testosterone concentration
was reduced significantly at 1ηg (P<0.05) and 1μg (P<0.01) doses as compared to control. Distinct
ultrastructural changes categorized as dilatation of cytoplasmic organelles, irregularly shaped nuclei
with nuclear membrane invaginations, reduced nuclear sizes, degeneration, and vacuolation
were observed in the kisspeptin-10 treated Leydig cells as compared to control. Quantification of
the data showed reduced Leydig cell indices and hyperplasia of the interstitial cells.

Conclusion:

It is concluded that chronic intermittent administration of kisspeptin-10 has a dose-dependent
degenerative effect on the plasma testosterone levels and Leydig cells ultrastructure in prepubertal
male rats.
H19: A Vital Long Noncoding RNA in the Treatment of Diabetes and Diabetic
Complications
Authors: Zhu Leiqi , Li Yuanyang , Xia Fangqi , Xue Mengzhen , Wang Yaqi , Jia Dengke , Gao Yan , Li Luoying , Shi Yue , Chen Silong , Xu Guangfu , Yuan Chengfu
Published: December 2021

Background:

Increasing academic efforts have been made to explore the correlation of long noncoding
RNAs (lncRNAs) with human diseases, particularly metabolic diseases like diabetes mellitus. Taking lncRNA
H19 as an example, this review intends to reveal the functions and mechanism of lncRNA H19 in diabetes
mellitus and diabetic complications.

Methods:

The research results associated with lncRNA H19 and diabetes mellitus are collected and summarized
on PubMed.

Conclusion:

LncRNA H19 is a potential instructive marker for the treatment of diabetes mellitus and diabetic
complications.
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas
aeruginosa: A Promising Combo
Authors: Khalifa Moad , Few Ling Ling , Too Wei Cun See
Published: December 2021

Background::

Pseudomonas aeruginosa is one of the most prevalent opportunistic pathogens
in humans that has thrived and proved to be difficult to control in this “post-antibiotic era.” Antibiotic
alternatives are necessary for fighting against this resilient bacterium. Even though phages
might not be “the wonder drug” that solves everything, they still provide a viable option to combat P.
aeruginosa and curb the threat it imposes.

Main findings::

The combination of antibiotics with phages, however, poses a propitious treatment
option for P. aeruginosa. Choline kinase (ChoK) is the enzyme that synthesizes phosphorylcholine
subsequently incorporated into lipopolysaccharide located at the outer membrane of gram-negative
bacteria. Recently, inhibition of ChoKs has been proposed as a promising antibacterial strategy. Successful
docking of Hemicholinium-3, a choline kinase inhibitor, to the model structure of P. aeruginosa
ChoK also supports the use of this inhibitor or its derivatives to inhibit the growth of this microorganism.

Conclusion::

Therefore, the combination of the novel antimicrobial “choline kinase inhibitors (ChoKIs)”
with a phage cocktail or synthetic phages as a potential treatment for P. aeruginosa infection has
been proposed.
Multifaceted Effects of Intermittent Fasting on the Treatment and Prevention
of Diabetes, Cancer, Obesity or Other Chronic Diseases
Authors: Tagde Priti , Tagde Sandeep , Bhattacharya Tanima , Tagde Pooja , Akter Rokeya , Rahman Md. Habibur
Published: December 2021

Background:

Obesity and diabetes are global epidemics resulting in a range of comorbidities.
Both have been linked to an increased risk of hormonal imbalance, cancer, and other significant
disorders, which are a concerning trend for cancer rates in the backdrop of rising obesity
and diabetes rates worldwide. Around 1 in 10 persons in the United States and Canada have serious
illnesses correlated to type 2 diabetes and early death. It is believed that the US economy alone
spends $245 billion annually due to this health burden. Lifestyle modification with intermittent
fasting protocol and proper diet helps lower blood glucose level, maintain the body mass index,
and reduce inflammation, which is the main cause of all chronic diseases.

Methods:

We searched case series and clinical trials on type 2 diabetes, insulin resistance, cancer,
thyroid, cardiovascular disease, or other inflammatory diseases in response to intermittent fasting
in the PubMed, MEDLINE, and Google Scholar databases.

Objective:

In this review, we have focused on intermittent fasting-based approaches that are becoming
more widely accepted for improving health and reducing unwanted effects in patients with
type 2 diabetes, cancer, cardiovascular disease, neurodegenerative disease, obesity, thyroid, and
hormonal imbalance; it is also contemplated whether intermittent fasting can be considered as a
non-medicinal therapeutic option for persons suffering from chronic diseases.

Conclusion:

Intermittent fasting successfully reversed diabetes, thyroid, and high blood pressure, elevated
lipid levels, and maintained the body mass index; also, studies have shown that it has been instructed
to be followed for the treatment and prevention of cancer and neurodegenerative diseases.
New Synthetic Sulfonamide Chalcone Induced Cell Cycle Arrest and Cell Death in
Colorectal Adenocarcinoma Metastatic Cells (SW-620)
Authors: Moura Andréa Felinto , de Castro Mirian Rita Carrilho , Naves Raquel Ferreira , Araújo Ana Jérsia , dos Santos Maria Claudia Luciano , Filho José Delano Barreto Marinho , Noda-Perez Caridad , Terra Martins Felipe , do O Pessoa Claudia , Filho Manoel Odorico Moraes
Published: December 2021

Background:

New chalcones have been developed from the insertion of organic groups, among them sulfonamides,
presenting varied biological activity.

Objective:

The aim of this work was to determine the antitumor potential of a new synthetic sulfonamide chalcone
(SSC185) against a colorectal metastatic lymph node-derived colorectal cancer cell line (SW-620).

Methods:

Synthesis and characterization, including crystallography, of SSC185 were performed. SSC185 showed a
selective cytotoxic effect against colorectal cancer cell lines. Therefore, the cytotoxic effect of SSC185 against SW-
620 was further investigated. We used optical and fluorescence microscopy, flow cytometry and Western blot to determine
the antitumor effects of SSC185.

Results:

SSC185 induced cytotoxicity in SW-620 cells in a time and concentration-dependent manner. Cell cycle progression
was disrupted, with increased G2/M cell number and consequent cell death, with morphological alterations
associated with apoptosis and necrosis. Cell death was associated with the activation and cleavage of PARP, and with
reduced expression of the pro-apoptotic Bax protein and caspase 8, depending on the SSC185 concentration tested.
Expression of the necroptosis pathway proteins RIP and MLKL was also reduced. These proteins are phosphorylated
during the process of necroptosis.

Conclusion:

We suggest that the mechanism involved in the cytotoxic effect of SSC185 against SW-620 in vitro may
be related to the induction of cell cycle arrest in the G2/M phase and cell death by apoptosis or necroptosis, depending
on the concentration used.
Speech as a Biomarker for Depression
Authors: Koops Sanne , Brederoo Sanne G. , de Boer Janna N. , Nadema Femke G. , Voppel Alban E. , Sommer Iris E.
Published: December 2021

Background:

Depression is a debilitating disorder that at present lacks a reliable biomarker
to aid in diagnosis and early detection. Recent advances in computational analytic approaches
have opened up new avenues in developing such a biomarker by taking advantage of the wealth
of information that can be extracted from a person’s speech.

Objective:

The current review provides an overview of the latest findings in the rapidly evolving
field of computational language analysis for the detection of depression. We cover a wide range of
both acoustic and content-related linguistic features, data types (i.e., spoken and written language),
and data sources (i.e., lab settings, social media, and smartphone-based). We put special focus on
the current methodological advances with regard to feature extraction and computational modeling
techniques. Furthermore, we pay attention to potential hurdles in the implementation of automatic
speech analysis.

Conclusion:

Depressive speech is characterized by several anomalies, such as lower speech rate,
less pitch variability and more self-referential speech. With current computational modeling techniques,
such features can be used to detect depression with an accuracy of up to 91%. The performance
of the models is optimized when machine learning techniques are implemented that suit the
type and amount of data. Recent studies now work towards further optimization and generalizability
of the computational language models to detect depression. Finally, privacy and ethical issues
are of paramount importance to be addressed when automatic speech analysis techniques are further
implemented in, for example, smartphones. Altogether, computational speech analysis is well
underway towards becoming an effective diagnostic aid for depression.
Legal protection of online loan recipients based on financial services authority
Authors: Myranika Annie
Published: December 2021

This study aims to determine the form of legal protection, dispute resolution, and provide legal understanding. The normative research method using a qualitative approach describes legislation and a case approach, and Law Number 21 of 2011 concerning the Financial Services Authority, Law Number 19 of 2016 ITE, and OJK Number 77/POJK.01/2016 concerning Borrowing Services. . Data collection techniques through (1). Interview, (2). Surveys (3). Documentation study. Conclusion (1). Many customers are victims as users of unlicensed services. (2). Efforts to protect customers against the implementation of OJK services (3). Cooperating with the Indonesian Joint Funding Fintech Association (4). Determination of the upper limit on loan interest and code of conduct for the loan collection process, (5). OJK cooperates with the Ministry of Communication and Information.
Impact of recycling sustainability on organizational performance
Authors: Odia Uchechukwuka Linus
Published: December 2021

This is empirical research focusing on the impact of recycling sustainability on Organizational performance in Nigeria. To achieve the objective of this study, a sample of 10 publishing houses in four major cities in Delta State was adopted, and these cities include Asaba, Warri, Sapele, and Oghara. Given that Nigeria is the regional publishing powerhouse in West Africa with newspaper publications selling in the whole region, likewise, textbook publishers in Nigeria dominate the regional market. The industry contributes about 10% of the GDP and is one of the fastest-growing in the manufacturing sector. Unfortunately, Nigeria does not produce most of the raw materials for publishing. All paper materials used in Nigeria are imported, and the costs are rising with the reliability of the sources dwindling. In addition, the publishing industry in Nigeria is faced with a high rate of waste and returns. The study focused on the impact of adopting recycling sustainability as a possible solution to the dwindling raw materials, increasing costs, and high rate of returns. It used a stratified random sampling approach and a descriptive research design.
The Role of Home Pocket Garden to Achieve Quality of Life during the Pandemic Era
Authors: Sanusi Aliyah Nur Zafirah , Abdullah Fadzidah , Othman Rosniza , Azmin Aida Kesuma , Yusof Zeenat Begam , Asif Nayeem
Published: December 2021

Before the pandemic, residents in the Klang Valley tend to prioritize indoor living space to outdoor. This study analyzed the importance of outdoor green space in residential buildings. It consists of two objectives; to identify the type of home pocket gardens used and to evaluate the significant impact of home pocket gardens on the quality of life (QOL) during the pandemic. A survey was conducted using a five-point Likert scale and distributed to three housing communities within the Klang Valley. The finding shows the positive role of the Home Pocket Garden on the Quality of Life during the pandemic.
Keywords: Pocket Garden, Quality of Life.
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3079