bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FAKTOR YANG MEMENGARUHI MINAT TOKO MENGGUNAKAN E-MARKET PLACE BUILDING MATERIAL UNTUK PENJUALAN BERBASIS APLIKASI
Authors: Wardhana Aditya Narendra , Jayanti Mirza May , Kurniawan Ilmanza Restuadi
Published: June 2019

This research has the basic purpose of finding the impact of Building Material Store Characteristics, Environmental Competitiveness and Promotion or support from Decision Maker to the interest/willingness of using E-Marketplace Building Material Semen Indonesia that defined as purchase intention in partially This research is a quantitative research. Data collection techniques used in this study is a questionnaire method with a likert scale of 1-7. The data analysis used is descriptive statistical data analysis method and to know what factors influence the interest/willingness of Store Owner in using E-Marketplace Building Material Semen Indonesia used multiple linear regression analysis. The results of this study indicate that the Building Material Store Characteristics, Environmental Competitiveness and Support from Decision Maker influence the interest/willingness of using E-Marketplace Building Material PT. Semen Indonesia that defined as purchase intention partially.
KEPUASAN MASYARAKAT TERHADAP PUBLIC SERVICE HALL DI KABUPATEN PAMEKASAN
Authors: Musoffan Musoffan , Darwis Darwis , Masrur Ahmad Rajaul
Published: June 2019

This study to assess community satisfaction with the public service hall in Pamekasan district as a breakthrough from the performance of the Pamekasan Regency Government.Retrieving data in this study by distributing questionnaires to the public using the Slovin Analysis formula used in this study, namely by using the public satisfaction index. The results of this study indicate that the Pamekasan Community Satisfaction Index towards Service Hall Public is 81,141 and based on the decision of the Minister of State Apparatus Number KEP / 25 / M.PAN / 2004 the value of the IKM is in the conversion interval value 62,51 - 81,25 with the predicate Good . The Public Service Hall in Pamekasan Regency was the first program in Madura and became the first breakthrough in Pamekasan Regency so that it received a certificate from the World-Indonesia Record Museum (MURI) category as the fastest district in establishing a Public Service Mall, this is nothing but the achievement of the District’s vision and mission Pamekasan headed to “Pamekasan Hebat“ which was Bhejjreh, Rajjheh and Parjhugeh.
PENINGKATAN KINERJA OPERASIONAL DENGAN MENGAKTIFKAN STANDAR OPERASIONAL PROSEDUR DI JAVA ORIGIN
Authors: Dewi Liliana , Fuldyanto Arvin
Published: June 2019

Java Origin is a company that runs in fashion field. The competition of the business world become tighten in accordance with the era. Various strategies are done by the company so that the company will not be left behind by the other competitors. One of the company’s strategy is to fix internal SOP. To know the role of SOP quality control towards operational performance of Java Origin. Determination of data source use purposive sampling with two speakers from internal employeer of Java Origin. One lecturer of Java Origin and one owner of business. The method that is used in this research is descriptive qualitative method. Data analysis use data reduction. Validation and data reliability that are used membercheck and triangulation source. The result of this research is the company is still lack concept out SOP. Java Origin company need to follow the existing SOP, does not interfere work division, implement evaluation system, built up more communication.
PAPERLESS OFFICE SEBUAH KEBUTUHAN KANTOR MASA DEPAN DI INDONESIA
Authors: Barnad Barnad
Published: June 2019

The development of computer technology and information and communication technology has entered all aspects of life both personally and business institutions such as offices. Work behavior patterns that still apply traditional offices with modern office equipment only produce work effectiveness, but have not produced work efficiency. In this paper, we will describe the results of traditional work behavior patterns, especially the use of wasteful paper, and how to make the most of information technology that has been owned to change traditional behavior patterns into modern ones which will result in a maximum reduction in paper use. Thus the achievement of work productivity is not only in the form of work effectiveness, but work efficiency can be achieved by applying modern work behavior. This change in work behavior indirectly plays a role in helping to improve the environment, because each sheet of paper used is the result of logging as the main ingredient. The application of modern work behavior patterns will have a significant impact if carried out jointly and thoroughly at each office.
PENGUATAN EKONOMI KELUARGA, MELALUI TABUNGAN SAMPAH DI KELURAHAN JUNGCANGCANG KECAMATAN PAMEKASAN, KAB. PAMEKASAN
Authors: Fawaid Akh. , Holis Moh.
Published: June 2019

Sampah selalu identik dengan hal-hal yang kotor, menjijikkan dan mendatangkan penyakit. Tetapi, jika sampah dikelola dengan baik, maka akan menghasilkan keuntungan besar. Keuntungan yang dimaksud ialah, dampak yang ditimbulkan atas pengelolaan sampah. Dalam penelitian ini, peneliti ingin mengetahui dampak pengelolaan sampah, pada penguatan ekonomi keluarga. Metode yang digunakan dalam penelitian ini, ialah metode penelitian diskriptif kualitatif, melalui pendekatan fenomenologi. Sasaranya, ialah masyarakat Kampung Laok Songai RT 02 RW 04, Kelurahan Juncancang, Kecamatan Pamekasan, Kabupaten Pamekasan. Teknik pengumpulan datanya dilakukan dengan cara wawancara mendalam, observasi dan dokumentasi. Manfaat penelitian ini, yakni meningkatkan kesadaran masyarakat akan mencintailingkungan bersih, serta mampu memberikan keuntungan dari tabungan sampah, untuk membantu meningkatkan penguatan ekonomi keluarga.
ANALISIS PELAKSANAAN PERATURAN PEMERINTAH NOMOR 23 TAHUN 2018 DAN PERATURAN MENTERI KEUANGAN NOMOR 215/PMK.03/2018
Authors: Soerjatno R. , Martantina Levi
Published: June 2019

Tax is one of the country income sources to develop a nation in achieving general welfare. Fundamentally, all implementation rules of the Taxation Law are for convenience for taxpayers, because with such convenience it is expected that tax compliance will continue to increase. Likewise, the enactment of Government Regulation Number 23 of 2018 in addition to lightening of the tax burden relief for taxpayers because previously with Government Regulation Number 46 of 2013 it was stipulated that the tax rate was 1%, but in mid2018 Government Regulation number 46 was revoked and replaced with Regulation Government number 23 of 2018 concerning income tax on income from business received or obtained by taxpayers who have certain gross circulation which sets a tax rate of 0.5%, so there is a tax relief in the form of a reduction in the tax rate of 0.5%. In Government Regulation of 2018 number 23, it is also stipulated that Taxpayers may choose not to count using Government Regulation of 2018number 23, but apply the Article 25 paragraph (7) of the Income Tax Law which we briefly call General Income Tax. Regarding the calculation of general income tax, it has been set in the Minister of Finance Regulation Number 215 / PMK.03 / 2018 which will take effect on December 1, 2018. Based on the discussion of the Minister of Finance Regulation Number 99 / PMK.03 / 2018 as the implementation rule of Government Regulation Number 23 of 2018, which the installment calculation of Income Tax Article 25 refers to Minister of Finance Regulation number 215 / PMK.03 / 2018 can be concluded that if the taxpayer choose to calculate the tax using Income Tax at the rate of Article 17 of the Income Tax Law, or has passed a certain gross circulation amount (Rp.4,800,000,000.00), or has passed a certain period of time required in Government Regulation number 23 of 2018, then The installment of Article 25 income tax in one tax year is NIL.
Tourist development between security and terrorism: empirical evidence from Europe and the United States
Authors: Stankova Mariya , Tsvetkov Tsvetomir , Ivanova Lyubov
Published: June 2019

Research background: Today?s world is torn between extreme conservatism and duality, in opposition, trying to break the classical framework of freedom in the movement of people. In the context of complex global relations, this impulse, especially related to the travels for tourism purposes, raises new issues concerning the safety and security. The tourism industry has a priority for the economic development of many countries in the world and is a large source of export earnings and, at the same time, an important factor in the balance of payments of a significant part of the national economies in the world. The growing importance of the tourism industry, however, puts tourist destinations worldwide at the forefront of new challenges, one of which is terrorism. In this environment, new relationships are emerging and this reflects on the development strategies, as well as on the financial outcomes of tourism industry which are also largely affected.
Purpose of the article: Respecting the new realities, the study explores the link between the risk of terrorism and the revenues from international tourism. Its main purpose is to investigate the impact of terrorism on the financial revenues from tourism in the European countries and the United States. The research is deter-mined by the perception that the financial flows from the international tourism are the quantitative manifestation of the hidden effects of the terrorism.
Methods: The research method includes a regression cross-section analysis and Granger Causality test. The survey is panel and includes 37 countries from Europe tourism region and the United States from Americas? tourism region (according UNWTO) for the period 2012?2017.
Findings & Value added: In conclusion, the effects of terrorism on the studied regions have been summarized, establishing dependence between terrorism and tourism, which illustrates a specific creative-destructive reflections of terrorism on tourism with regions particularities.
Harmonization of the protection against misleading commercial practices: ongoing divergences in Central European countries
Authors: MacGregor Pelikánová Radka
Published: June 2019

Research background: Modern European integration focuses on competition in the internal single market, embracing both competitiveness and consumer protection, and it aims at full harmonization in this arena. The hallmark, the Unfair Commercial Practices Directive from 2005, aims to overcome diverse social, political, legal and economic traditions. Is the implied protection against misleading practices an opportunity or a threat for Central European Regions?
Purpose of the article: The primary purpose is to comparatively describe and critically assess the transposed legal frameworks. The secondary purpose is to study and evaluate their coherence in the light of the case law and their impact in Central Europe, in particular whether it represents an opportunity or a threat for the smart, sustainable and inclusive growth, i.e. boosting competitiveness and innovation along with consumer welfare.
Methods: The cross-disciplinary and multi-jurisdictional nature of this paper, and its dual purposes, implies the use of Meta-Analysis, of various interpretation techniques suitable for legal texts and judicial decisions, of the critical comparison and of a holistic assessment of approaches and impacts. Legislation and case law are explored and the yielded knowledge and data are confronted with a field search and case studies. The dominating qualitative research and data are complemented by the quantitative research and data.
Findings & Value added: For over one decade, the Unfair Commercial Practices Directive has required full harmonization of the protection against, among other items, misleading commercial practices, by legislatures and judges in the EU. The exploration pursuant to the two purposes suggests that this ambitious legislative and case law project entails a number of transposition approaches with varying levels of coherence, importance and impacts on the competitiveness and innovation of business and consumer welfare in Central Europe. Therefore, full harmonization should be either readjusted or relaxed.
Economic analysis of implementing VMI model using game theory
Authors: Stehel Vojtěch , Vochozka Marek , Kliestik Tomas , Bakes Vladimir
Published: June 2019

Research background: The article deals with implementing VMI between the supplier and customer. To assess whether the system will be implemented, the evolution game theory is used. The contribution is based on the limitations of the study of the evolutionary game theory approach to modelling VMI policies (Torres et al., 2014) and its later extension, The evolutionary game theory approach to modelling VMI policies (Torres & García-Díaz, 2018). It aims is to complement the studies and provide a comprehensive picture of the issue.
Purpose of the article: The main objective of the contribution is to respond to the question whether the VMI system will be introduced between the supplier and customer.
Methods: In the first phase, the matrix is analysed from the point of view of the game meaning and its limit parameters. The limit parameters are set taking into account the economic reality. The only examined states of the matrix are those where the result is not obvious. For the purposes of the contribution, we work with a 5-year period. A new software capable of calculating evolutionary focus and their stability is created. Sensitivity analysis is carried out for the individual parameters that affect the system behaviour.
Findings & Value added: Value added is a complex description of the system and complementation of previous studies in this field. VMI is confirmed. The results obtained can be used for practical management, so that the managers are able to identify what the actual costs are and what the probability of introducing the sys-tem is. At the same time, they can identify the parameters that can be influenced by them and observe their impact on the shift of the system introduction probability.
Supply chain development drivers in industry 4.0 in Ukrainian enterprises
Authors: Krykavskyy Yevhen , Pokhylchenko Olena , Hayvanovych Nataliya
Published: June 2019

Research background: Industry 4.0 is a response to rapid technical progress, caused by the dominant role of information technology, which covers and penetrates virtually into all the aspects of people's economic and social activities. At present, the terms ?Digital Supply Chain?, ?Supply Chain 4.0?, ?Digital logistics?, and ?Smart logistics? are widely used in business, and in particular, in the theory and practice of supply chain management (SCM). This demonstrates the relevance of the implementation of Industry 4.0 innovations into the practical activities of manufacturing, trading, and logistics companies, interconnected by networking in the process of delivering products or services to final consumers. In turn, this causes fundamental changes in the structure of supply chains, their business processes and behaviours, making existing approaches to management obsolete.
Purpose of the article: The article aims at identifying supply chain development drivers under the conditions of ?Industry 4.0?; determining the effect of DT in the cross-section of strategic and operational changes of supply chain; clarifying the readiness and capacity for DT implementation in the enterprises activity as exemplified by the enterprises operating in Ukraine in various fields of activity.
Methods: Stratified proportional sampling was applied as the research method. Ukrainian enterprises of different size, involved in different supply chains, were considered as an object of research. The attitude of the Ukrainian enterprises to the DT implementation is presented, and the results are compared to the relevant research data in other countries.
Findings & Value: This study will be valuable to both scientists and practitioners. Scientists will be able to understand the conceptual transformation of SC under the influence of DT. Practitioners will become aware of the following issues: current SCM trends and requirements; DT effects on the strategic and operational levels of the classical model of management; the level of readiness and ability of the Ukrainian enterprises to implement DT in their activities as compared to the enterprises in other countries.
External linkages and intellectual assets as indicators of firms? innovation activities: results from the Czech Republic and Poland
Authors: Zygmunt Aleksandra
Published: June 2019

Research background: Firms? innovation activities play an important role in fostering firms? competitiveness and enhancing economic growth of regions and countries. Regarding the significance of the issue, it is essential to explore indicators of firms? innovation activities. Here, special attention was given to external linkages and intellectual assets. In the study, particular emphasis was put on firms from the Czech Republic and Poland as the countries distinguished by similar innovation performance.
Purpose of the article: The aim of this paper is to explore whether external link-ages and intellectual assets impact on innovation activities of Czech and Polish firms.
Methods: In the study, the Cobb-Douglas function was employed. The study used data from the European Innovation Scoreboard 2018 with regard to firms? innovation activities. In particular, special stress was put on variables related to external linkages and intellectual assets such as: innovative SMEs collaborating with others, private co-funding of public R&D expenditures, PCT patent applications and trademark applications. The time period was 2008?2015.
Findings & Value added: This paper contributes to the existing literature by providing new insight on issues connected with indicators of firms? innovation activities. The results reveal statistical significance of selected variables connected with external linkages and intellectual assets on innovation activities of Czech and Polish firms. These findings have policy and practical implications. There is a need to further stimulate, among others, the linkages between firms and universities, research organisations, institutional environment.
Disclosure of intellectual capital in financial reports: case of Latvia
Authors: Lentjushenkova Oksana , Zarina Vita , Titko Jelena
Published: June 2019

Research background: Intellectual capital and its elements, such as reputation, customer relationships, staff competence, are an essential part of a company?s value. However, the issues regarding its recording in company?s accounting books have not been solved. Proper disclosure of an intellectual capital in financial re-ports will increase the transparency of company-related information, thus improving the quality of reporting.
Purpose of the article: The paper aims to investigate the opportunities of intellectual capital disclosure in company?s financial reports from the viewpoint of accounting experts.
Methods: Financial and accounting managers, board members of accounting services, companies and auditors were surveyed, using the authors? developed questionnaire. The statements regarding the awareness of the intellectual capital and its disclosure-related questions, as well as a respondent profile section were offered to respondents for evaluation. Data was processed in SPSS, applying the method of frequency analysis and categorical Principal Component Analysis (CATPCA).
Findings & Value added: The research results indicate the problem of inconsistency between understanding of intellectual capital and its elements in management theory and accounting practice. The existing accounting standards and regulations do not allow for making a full disclosure of all companies? assets. Thus, a reliable information about company?s value is not available for shareholders, executives and other stakeholders. The authors suggest using a non-financial reporting practice to reflect the real situation in all companies, irrespective to their status within the meaning of the European Directive on non-financial information disclosure. Current research results will be used for future research and elaboration of recommendations to companies for better disclosure of their assets. Besides, there is a potential for future studies regarding non-financial reporting practice and disclosure of intellectual capital in neighboring countries.
Differences in perception of regional pro-entrepreneurial policy: does obtaining support change a prospect?
Authors: Zajkowski Robert , Domańska Ada
Published: June 2019

Research background: In the paper, we presented a most crucial aspect of the entrepreneurial ecosystem in a regional context that seems to be more visible than the general approach. The role of entrepreneurs and support institutions as one of the main actors of a regional entrepreneurship ecosystem was underscored. We also stressed the significance of entrepreneurs? opinions related to Business Support Institutions (BSI) as sources of feedback and potential boosters of delivery and promotion that can be used by regional stakeholders and policymakers.
Purpose of the article: The aim of this paper is to investigate significant differences in a perception of regional pro-entrepreneurial institutions between businesses that obtained or did not obtain support.
Methods: Our study is based on data collected in Lubelskie Voivodeship, hence they refer to a single region in Poland. The sample totalled 386 responses, and we conducted numerical analyses by using the logit linear regression model. As the dependent variable, we used a dual-variable (not supported; supported) that describes two groups of enterprises, i.e. those that do not get and those that got some sort of public support. As independent variables, we adopted 18 factors that depict ordinary scale perception of various aspects of regional pro-entrepreneurial policy.
Findings & Value added: Analyses revealed nine statistically significant relationships between perception of regional BSI impact on enterprises functioning and regional entrepreneurial ecosystem depending on whether particular enterprises got or did not get support, e.g. a favourable experience in obtaining support boosts positive perception that support from BSI influences positively the decision to set up one's own business. BSI at Lubelskie Voivodeship acts in favour to create bonds between enterprises, and support from BSI increases opportunities to survive in the market. Moreover, supported enterprises perceived better aspects, such as positive influence on enterprises? innovativeness thanks to BSI, and more are convinced that support programmes of BSI are available for a broad group of companies.
Seroprevalencia de paratuberculosis bovina mediante la prueba de ELISA urea en rodeos de cría y de leche con sospecha de la enfermedad, localizados en la provincia de Buenos Aires, Argentina
Authors: Alvarado Pinedo María Fiorella , Di Paolo Leandro Adrián , Sosa Pedro Sebastián , Romero Magali Andrea , Peralta Luis María , Costa Enrique Felix , Travería Gabriel Eduardo
Published: June 2019

Se presentan los resultados obtenidos en 17.747 sueros analizados para el diagnóstico serológico de paratuberculosis bovina, provenientes de 85 rodeos de cría y 5 de leche, ubicados en 14 partidos de la provincia de Buenos Aires. La prueba de ELISA permite diagnosticar esta enfermedad en estadio subclínico, y la incorporación de urea mejora la eficiencia para detectar los anticuerpos específicos contra el Mycobacterium avium subsp. paratuberculosis (MAP). Se estimó la seroprevalencia sobre la base de los resultados obtenidos de animales caracterizados como positivos y sospechosos en la prueba de ELISA urea. Se observó una seroprevalencia individual del 5,5 % en los rodeos de cría y del 13,6 % en los rodeos lecheros, siendo la seroprevalencia predial del 78,8 %. De 425 muestras de heces cultivadas se aisló MAP en el 67,6 % de los animales positivos, del 52,7 % de los sospechosos y del 7 % de los negativos por la prueba de ELISA urea. Mediante estadística bayesiana, el valor predictivo positivo de esta prueba fue de 0,61 y el valor predictivo negativo de 0,93. Nuestros resultados aportan información actualizada sobre la estimación de la seroprevalencia regional de paratuberculosis bovina, la cual es elevada, y confirma la utilidad de la prueba de ELISA urea, desarrollada localmente, en el diagnóstico y control de la enfermedad.
Vía intranasal: una alternativa para la administración de fármacos de acción central en equinos
Authors: Velloso María Inés , Ferreira Violeta , Vita Mariangeles , Landoni María Fabiana
Published: June 2019

La vía intranasal es reconocida en medicina humana como una vía muy promisoria para la administración sistémica y cerebral de fármacos. Es una vía de administración indolora, incruenta, económica y práctica. Por sus características, es muy útil para la aplicación de fármacos en pacientes con alteraciones orales, con diarrea o que no cooperen. Además, es una potencial vía directa al sistema nervioso central (SNC). Su uso en medicina veterinaria es muy raro, salvo para la administración de tratamientos locales. En la especie equina, aun cuando no hay estudios completos y profundos sobre las características anatomofisiológicas de la cavidad nasal, su gran superficie e irrigación (área potencial de absorción) permiten inferir su viabilidad para la administración sistémica de fármacos. En el presente artículo se discuten las características de la cavidad nasal de los equinos en relación a las diversas vías de absorción sistémica y del transporte nariz-cerebrode fármacos, así como las potenciales aplicaciones de esta vía de administración.
De reactivo biológico al animal sintiente: el bienestar animal como cambio de paradigma en la investigación biomédica y su impacto en los resultados
Authors: Maschi Fabricio , Carbone Cecilia , Ferrari Hector Ricardo
Published: June 2019

El uso de animales como reactivos biológicos para investigación científica se ha justificado desde los inicios de la civilización, cuando solo servían para satisfacer las necesidades del hombre. El concepto de reactivo biológico ha cambiado al cobrar relevancia el bienestar animal, una problemática específica de la relación humano animal referida inicialmente a los animales de producción y que ha impactado en todos los usuarios de animales. Se logró avanzar en el conocimiento de las especies, sus necesidades y en la comprensión de su comportamiento. Con esta redefinición del animal surge un nuevo objeto de estudio para la ciencia: el estado del animal en sus intentos de lidiar con su entorno y de afrontar las demandas del ambiente. Como consecuencia, se han realizado enriquecimientos del ambiente sin suficientes estudios previos llevandoa la obtención de resultados erróneos. Por lo tanto, es imperativo trabajar con indicadores específicos de bienestar que permitan diagnosticar y remediar las condiciones de pobre bienestar. Los animales provistos a los investigadores deberían contar con certificaciones sobre la cepa, condiciones de crianza y, además, tipo y modalidad de enriquecimiento e indicadores de bienestar animal antes de iniciar su utilización. En el futuro, el bienestar animal no solo debe estar en la nota ética, sino que debe ser parte inexcusable de la sección metodológica de los estudios experimentales.
The phenomenon of conversion of the donor-derived blood group to the patient’s original blood group after ABO-incompatible hematopoietic stem cell transplantation in a patient with Wiskott–Aldrich syndrome
Authors: Khoreva A. L. , Trachtman P. E. , Kozlovskaya S. N. , Mitrakov K. V. , Brilliantova V. V. , Popov A. M. , Balashov D. N.
Published: June 2019

We present a clinical case of hematopoietic stem cell transplantation (HSCT) in a patient with Wiskott-Aldrich syndrome. In spite of donor different ABO-system, the own blood group was verified in 6 months after HSCT, which was initially regarded as a risk of myeloid rejection. During the diagnosis, the hypothesis of absorption of the recipient’s ABO-system proteins onto the donorderived red blood cells was confirmed. The study of the immunological profile allowed to exclude the risks of hemolytic reactions and to predict a favorable outcome in the patient. Parents gave their consent to use information about the child in the article.
Clinical case of proteasome-associated autoinflammatory syndrome-2 (PRAAS2)
Authors: Terentieva A. I. , Viktorova E. A. , Zaharova V. V. , Konovalov D. V. , Burlakov V. I. , Rodina J. A. , Kuzmenko N. B. , Raikina E. V. , Kozlova A. L.
Published: June 2019

This article describes clinical case of a child with proteasome-associated autoinflammatory syndrome-2 (PRAAS2). First two cases in unrelated boys were described in July, 2018 by M. Cecilia Poli, Frederic Ebstein. We describe another case of PRAAS2. Mutations of the POMP-gene underlie PRAAS2 pathogenesis, causing defects of the POMP protein which plays important role in proteasomes maturation and leads to the clinical symptoms observed in three described cases. We also provide a short PRAAS2 background description, as well as key pathogenesis components, clinical findings description and analysis of three known PRAAS2 cases. Parents gave their consent to use personal data, including photos for clinical research and publications.
αβ-T-cell-depleted haploidentical hematopoietic stem cell transplantation in children with chemorefractory acute myeloid leukemia
Authors: Shelikhova L. N. , Ilushina M. A. , Semiglazova K. V. , Shekhovtsova Zh. B. , Shasheleva D. A. , Khismatullina R. D. , Kurnikova E. E. , Pershin D. S. , Balashov D. N. , Radygina S. A. , Trakhtman P. E. , Kalinina I. I. , Muzalevskii Y. O. , Kazachenok A. S. , Zaharova V. V. , Brilliantova V. V. , Olshanskaya Yu. V. , Panferova A. V. , Zerkalenkova E. A. , Baidildina D. D. , Novichkova G. A. , Rumyantsev A. G. , Mascha A. A. , Maschan M. A.
Published: June 2019

Primary refractory and relapsed refractory acute myeloid leukemia remains an unresolved problem in pediatric oncology. Children with AML who fail to achieve complete remission on high-dose cytarabine and antracyclines have no chance for survival without allogeneic hematopoietic stem cell transplantation. We evaluated the outcome of αβ-T-cell-depleted haploidentical transplantation in a cohort of children with chemorefractory acute myeloid leukemia. Thirty-six patients with either primary refractory (n = 14) or relapsed refractory (n = 22) acute myeloid leukemia in active disease status received a transplantation from haploidentical donors. The preparative regimen included cytoreduction with fludarabine and cytarabine and subsequent treatment with treosulfan and either melphalan or thiophosphamide. Serotherapy consisted of antithymocyte globuline in 14 pts and targeted immunomodulation with tocilizumab +/- abatacept in 22 pts. Grafts were PBSCs engineered by TCR-αβ/CD19 depletion. Posttransplant preemptive therapy included modified donor lymphocyte infusions with or without hypomethylating agents. Complete remission was achieved in 30 (83%) рts. The cumulative incidence of acute GVHD grade II–IV was 25%, and the cumulative incidence of chronic GVHD was 18%. Transplant-related mortality was 6%, and relapse incidence was 48%. Event-free survival was 46%, and overall survival was 41% at 2 years. Good early recovery of NK cells was associated with significantly improved survival and decreased relapse incidence. Our data suggest that αβ-T-cell-depleted haploidentical HSCT provides a reasonable chance of cure in a cohort of children with chemorefractory acute myeloid leukemia and creates a solid basis for further improvement. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology.
Steroid cataract in patients with hemoblastosis
Authors: Smirnova A. B. , Pershin B. S. , Myakova N. V.
Published: June 2019

Modern technologies of treatment of children with oncohaematological diseases allowed to noticebly increase the survival indexes in this group of patients, enhancing the value of maintenance of their life quality. More than half of those who received long-term steriod and radiation treatment develop cataract that causes decrease in vision. In this review we represent data concerning mechanisms of cataract formation in patients after steriod and radiation treatment, results of anatomical, physiological and biochemical studies of the lens as well as metabolic changes in aqueous humor leading to cataract formation.
Evaluation of abatacept for GVHD prophylaxis in patients with non-malignant diseases after hematopoietic stem cell transplantation
Authors: Radygina S. A. , Vasilieva A. P. , Kozlovskaya S. N. , Shipitsyna I. P. , Livshits A. M. , Gutovskaya E. I. , Shelikhova L. N. , Balashov D. N.
Published: June 2019

Graft-versus-host diseases (GVHD) is one of most significant complication after allogeneic hematopoietic stem cells transplantation (HSCT). T-cell activation is a major stage in the GVHD pathogenesis. T-cells require 2 signals for activation: cognate antigen/MHC binding T-cell receptors and positive costimulatory signals from antigen-presenting cells (APC). The predominant positive costimulatory signal to human CD4 T0-cells comes through the CD28 receptor. This signal can be blocked by fusion proteins (such as CTLA4-Ig). Abatacept is a soluble fusion protein, which links the extracellular domain of human CTLA-4 to the modified Fc portion of human IgG1. We present results of single-center prospective randomized study to evaluate the efficacy of adding abatacept to the GVHD prophylaxis protocol after hemopoietic stem cell transplantation in patients with non-malignant diseases. Study was approved by Ethics Committee and Scientific Council of the Institute (protocol # 9/2013 from 01.10.2013). During 4 years we included 62 patients, 30 of them received abatacept as additional agent. Cumulative incidence of acute GVHD was significantly lower in this group in compare with control group (p = 0,018). When we stratified patients in dependents of graft processing technology, we did not see any advantages of abatacept in patients after transplantation with TCRαβ+/СD19+ graft depletion. However, after HSCT with non-manipulated graft the abatacept showed significant efficacy in aGVHD prophylaxis compared with control group (p = 0,024). Abatacept can be recommended as effective additional agent for GVHD prophylaxis after allogeneic HSCT in patients with non-malignant diseases.
The experience of hematopoietic stem cell transplantation in primary immunodeficiencies in the Russian Children's Clinical Hospital
Authors: Machneva E. B. , Skorobogatova E. V. , Pristanskova E. A. , Konstantinova V. V. , Burya A. E. , Olkhova L. V. , Sidorova N. V. , Mezentseva A. V. , Kirgizov K. I. , Blagonravova O. L. , Nikolaeva Yu. A. , Filina O. A. , Vakhlyarskaya S. C. , Skvortsova Yu. V. , Kondratenko I. V. , Bologov A. A. , Maschan A. A.
Published: June 2019

Primary immunodeficiencies (PID) include a group of congenital diseases, many of which are associated with a high risk of developing life-threatening infectious and non-infectious complications. Many of PIDs require hematopoietic stem cell transplantation (HSCT), which can lead to a complete cure of the disease. The article presents more than 20 years of experience in conducting HSCT with PID in the Russian Children's Clinical Hospital for the period from 1997 to 2018. 88 HSCTs were performed in 80 patients (64 boys and 16 girls) with various PIDs: severe combined immune deficiency (SCID, n = 34), hemophagocytic lymphohistiocytosis (HLH, n = 12), chronic granulomatous disease (CGD, n = 11), Wiskott–Aldrich syndrome (WAS, n = 10), congenital agranulocytosis (n = 4), hyper IgM syndrome type 1 (n = 3), Nijmegen breakage syndrome (n = 2), lymphoproliferative syndrome (n = 2), Chediak–Higashi syndrome (n = 1), leukocyte adhesion deficiency (n = 1). Оverall survival (OS) and event-free survival (EFS) after HSCT with PID was 63.1% and 49.3%. OS after HSCT with SCID was 65.5%, EFS – 48.4%. The article presents the results of HSCT taking into account the type of HSCT, the source of hematopoietic stem cells (HSC) and the type of graft manipulation, conditioning regimen. Growth of positive results of HSCT in patients with PID in recent years is associated with the improvement of accompanying therapy (improving the quality of infection control, the introduction of new drugs for the prevention and treatment of hepatic veno-occlusive disease); technology application TcRα+β+/CD19+ depletion at haploidentical transplantation; optimization of conditioning regimens; successes in the prevention and treatment of the graftversus- host disease (antithymocyte globulin and rituximab administration during the period of conditioning, post-transplant administration of cyclophosphamide at haploidentical HSCT). The study was approved by the Independent Ethics Committee of Russian Children's Clinical Hospital.
Invasive candidiasis in children after hematopoietic stem cell transplantation
Authors: Markova I. V. , Rogacheva Yu. A. , Popova M. O. , Volkova A. G. , Ekushov K. A. , Frolova A. S. , Shvetcov A. N. , Nikolaev I. Y. , Ignatyeva S. M. , Bogomolova T. S. , Pinegina O. N. , Gevorgian A. G. , Paina O. V. , Bykova T. A. , Goloshchapov O. V. , Vladovskaya M. D. , Moiseev I. S. , Zubarovskaya L. S. , Klimko N. N. , Afanasyev B. V.
Published: June 2019

Invasive fungal disease due to Candida spp. – Invasive candidiasis/candidaemia, is a life-threatening complication in immunosuppressed patients. The publications on epidemiology of invasive candidiasis (IC) in children after hematopoietic stem cell transplantation (HSCT) is limited. The purpose of the study was to study the epidemiology of IC in children after HSCT for the 7 years in Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation. In 2009–2016 yy have been performed 754 HSCT in children: 494 allogeneic and 260 autologous. The study was approved by the Independent Ethics Committee of the Raisa Gorbacheva Memorial Research Institute of Children's Oncology, Hematology and Transplantation. A retrospective study included 22 cases of invasive candidiasis in after HSCT. EORTC/MSG 2008 criteria were used for the diagnosis of proven invasive candidiasis as well as to evaluate response to therapy. Incidence of IC was 2.9%: allo-HSCT – 3% (n = 15), auto-HSCT – 2,7% (n = 7). The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology. The etiology: Candida parapsilosis – 50%, Candida albicans – 27%, Candida krusei – 14%, Candida tropicalis – 5%, Candida dubliniensis – 4%. The most frequent underlying diseases was acute leukemia – 45% (n = 10). The median age was 8 y.o. (3 month–18 years). The median day of onset of IC after allo-HSCT was 63 days (4–243), auto-HSCT – 12 days (3–20). Febrile fever was the main clinical symptom; septic syndrome develops in 32% cases. Antifungal therapy was with echinocandins – 23%, lipid ampho B – 27%, triazole (fluconazole, voriconazole) – 32%, without therapy (due to early mortality) – 18%. Overall survival (OS) at 30 days from diagnosis invasive candidiasis was 50%. The central venous catheter (CVC) removal was the only factor significantly improved OS (70% vs 33%, p = 0,035). Incidence of Invasive candidiasis in children after hematopoietic stem cell transplantation was 2.9%. The main etiology agent was Candida parapsilosis. Invasive candidiasis infections most often affect leukemia patients, after allo-HSCT developed later than auto-HSCT. Overall survival at 30 days from the diagnosis was 50%. Removing of CVC improved overall survival in children with invasive candida infections after HSCT
Brentuximab vedotin in the treatment of children and adolescents with refractory and relapsed Hodgkin's lymphoma
Authors: Kozlov A. V. , Kazantzev I. V. , Iukhta T. V. , Tolkunova P. S. , Gevorgian A. G. , Lepik K. V. , Borzenkova E. S. , Zaljalov Yu. R. , Botina A. V. , Baikov V. V. , Morozova E. V. , Mikhailova N. B. , Zubarovskaya L. S. , Afanasyev B. V.
Published: June 2019

Children and adolescents with refractory or relapsed Hodgkin's lymphoma (R-R HL) have unfavorable prognosis if ≥ 3 lines of therapies have to be used. New strategies based on innovative approaches are crucial for this group of patients. Nowadays immunotherapy for oncological diseases is the most promising and actively developing area. Brentuximab vedotin (BV) is efficient in adults with HL. Data in children are limited to pilot studies that are focused on response to treatment without analysis of survival. The present study demonstrates experience of Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation (First Pavlov State Medical University of Saint-Petersburg) in the management of heavily pretreated (median number of prior lines – 4) children and adolescents with R-R HL. The study was approved by the Independent Ethics Committee of the Raisa Gorbacheva Memorial Research Institute of Children's Oncology, Hematology and Transplantation. Brentuximab vedotin was administered to 34 patients. Overall response was achieved in 71% (complete response – 29%, partial response – 42%). Long-term progression free and overall survival were 24 and 54%, respectively.
Efektivitas Berkomunikasi Dan Hasil Belajar Siswa Kelas IV SD Pada Pembelajaran IPA Melalui Model Open Ended
Authors: Santika Mira
Published: June 2019

Jenis penelitian ini adalah tindakan kelas, dengan subjek siswa kelas IV SD. Penelitian dilakukan pada semester genap tahun ajaran 2015/2016, instrumen penelitian yang digunakan adalah efektivitas berkomunikasi lembar siswa, lembar penilaian hasil belajar pada aspek kognitif siswa pada level pengetahuan dan pemahaman. Berdasarkan hasil penelitian, efektifitas berkomunikasi siswa pada siklus I memperoleh nilai rata-rata peningkatan 49,99% pada siklus II menjadi 67,45%, efektivitas berkomunikasi siswa pada siklus I memperoleh nilai rata-rata 53,96% meningkat pada siklus kedua menjadi 71,42%. Hasil belajar siswa pada tingkat kognitif pengetahuan pada siklus I meningkat pada siklus II 68,33 menjadi 80,47, hasil belajar kognitif pada level pemahaman pada siklus I meningkat pada siklus II 58,09 menjadi 71,42. Dapat disimpulkan bahwa model open ended dapat meningkatkan efektifitas komunikasi dan hasil belajar siswa pada pembelajaran IPA kelas IV SD.
Studi Morfologi Koloni Bakteri Udara Di Lingkungan Fakultas Tarbiyah Dan Tadris Institut Agama Islam Negeri Bengkulu
Authors: Walid Ahmad , Novitasari Naintyn , Wardany Kusuma
Published: June 2019

Abstrak. Kualitas udara sangat harus diperhatikan bagi setiap makhluk hidup. Ada beberapa faktor yang dapat membuat kualitas udara menurun salah satunya mikroorganisme. Mikroorganisme udara bisa disebabkan akibat banyaknya aktivitas manusia dan kondisi fisik dari lingkungan tersebut Fakultas Tarbiyah dan faktor tersebut Masalah dalam ini (1) Bagaimana morfologi koloni bakteri udara di lingkungan Fakultas Tarbiyah dan Tadris Institut Agama Islam Negeri Bengkulu?; (2) Bagaimana pemahaman mahasiswa terhadap morfologi koloni bakteri udara di lingkungan Fakultas Tarbiyah dan Tadris Institut Agama Islam Negeri Bengkulu? Tujuan penelitian ini: (1) Untuk mengetahui morfologi koloni bakteri udara di lingkungan Fakultas Tarbiyah dan Tadris Institut Agama Islam Negeri Bengkulu; (2) Untuk mengetahui pemahaman mahasiswa terhadap morfologi koloni bakteri udara di lingkungan Fakultas Tarbiyah dan Tadris Institut Agama Islam Negeri Bengkulu. Penelitian ini menggunakan metode deskriptif kualitatif dan kuantitatif. Berdasarkan data yang diperoleh dari hasil penelitian diketahui: (1) 15 jenis koloni bakteri udara pada ruang berAC, kemudian 8 jenis koloni bakteri udara pada ruang non AC, dan 11 jenis koloni bakteri udara pada ruang terbuka dengan ciri-ciri koloni yang berbeda-beda
Karakteristik Biochar Hasil Pirolisis Ampas Tebu (Sacharum Officanarum, Linn) Dan Aplikasinya Pada Tanaman Seledri (Apium Graveolens L)
Authors: Asyifa Diena , Gani Abdul , Rahmayani Ratu Fazlia Inda
Published: June 2019

Telah dilakukan penelitian tentang mengolah ampas tebu (Sacharum officanarum, Linn) menjadi biochar melalui proses pirolisis dan aplikasinya pada tanaman seledri (Apium graveolens L.). Penelitian dilakukan untuk mengetahui karakteristik biochar hasil pirolisis ampas tebu serta aplikasinya pada tanaman seledri. Jenis penelitian eksperimen menggunakan pendekatan kuantitatif. Data penelitian bersumber dari sampel ampas tebu yang diperoleh dari pedagang air tebu di sekitar jalan Rukoh. Penelitian dilakukan dengan mengolah ampas tebu menjadi biochar dengan proses pirolisis dan dilanjutkan dengan mengkarakterisasi biochar seperti rendemen, kadar air, kadar abu, kadar C/N, nilai pH serta aplikasinya terhadap tanaman seledri. Hasil yang didapatkan yaitu: (1) Rendemen biochar yang dihasilkan dari ampas tebu pada proses pirolisis sebesar 18,34%, (2)Hasil  kadar air biochar sebesar 10,2%, (3) Kadar abu yang dihasilkan dari biochar sebesar 1 gram sebesar 68%, (4)Kadar C pada biochar sebesar 55,66% dan kadar N sebesar 0,40% sedangkan kadar C/N rasio yaitu 139.15, (5)Nilai pH pada biochar ampas tebu yaitu 5,196 dan (6)Hasil analisis sidik ragam dari aplikasi biochar yang telah dilakukan pada tanaman seledri yaitu menunjukkan tidak nyata. Dengan demikian disimpulkan bahwa karakteristik biochar yang didapatkan lebih tinggi dari Standar Nasional Indonesia
Pemahaman Nature of Science (NoS) Di Era Digital: Perspektif Dari Mahasiswa PGSD
Authors: Tursinawati Tursinawati , Widodo Ari
Published: June 2019

Hakikat IPA merupakan cara berpikir seseorang dalam memahami konsep-konsep ilmiah melalui metode ilmiah dengan berbagai tahapan dan metodologi yang sistematis sehingga dapat menghasilkan temuan atau ilmu pengetahuan, oleh sebab itu pentingnya pemahaman NOS dalam pembelajaran. Penelitian ini bertujuan untuk mengetahui perspektif mahasiswa Pendidikan Guru Sekolah Dasar (PGSD) tentang pemahaman hakikat IPA atau nature of science (NoS) di era digital. Jenis penelitian yang dilakukan adalah deskriptif dengan metode survei. Sampel dari penelitian ini 61 orang mahasiswa PGSD yang berasal dari 27 responden Universitas Kuningan dan 34 responden Universitas Syiah Kuala. Teknik sampling yang digunakan adalah teknik acak. Instumen yang digunakan dalam penelitian berupa angket yang berisi 28 item pernyataan. Hasil penelitian menunjukkan bahwa secara umum rata-rata tanggapan mahasiswa PGSD terhadap NoS di era digital memberikan tanggapan yang baik, hal ini ditunjukkan dengan memperoleh 68% berada pada kategori baik. Agar mahasiswa PGSD memiliki pemahaman NoS di era digital yang lebih baik maka hendaknya pendalaman konsep tentang hakikat IPA era digital menjadi prioritas dalam pembelajaran IPA di Perguruan Tinggi.
Komunikasi Matematik Dalam Pembelajaran Dengan Menggunakan Pendekatan Realistik
Authors: A Herwati
Published: June 2019

Penelitian ini bertujuan untuk mengetahui efektifitas pendekatan realistik dalam meningkatkan kemampuan komunikasi matematika. Subjek ini melibatkan sebanyak 69 siswa kelas X di Sekolah Menengah Atas Negeri 1 Tembilahan Indra Giri Hilir Riau. Sebanyak 35 siswa (19 laki-laki 16 perempuan) untuk pembelajaran yang menggunakan pendekatan realistik dan 34 siswa (19 laki-laki 15 perempuan) untuk kontrol. Pengumpulan data dilakukan sebanyak dua kali yaitu pada ujian pretes dan postes yang menggunakan waktu selama delapan minggu. Ujian komunikasi matematika meliputi aspek drawing, mathematical expression, dan written texts. Hasil penelitian ini menunjukkan peningkatan kemampuan komunikasi matematika aspek drawing, mathematical expression, dan written texts. Kemampuan komunikasi matematika lebih tinggi apabila menggunakan pendekatan realistik dibandingkan dengan tanpa realistik. Pendekatan realistik memberikan kesempatan kepada siswa untuk menjadi lebih aktif dalam pengajaran dan pembelajaran matematika. Pembelajaran matematika dengan pendekatan realistik memberikan peluang kepada siswa untuk mengungkapkan ide matematika dalam bentuk tulisan maupun lisan. Siswa leluasa menuliskan konsep-konsep matematika yang diperolehnya dan berpendapat secara matematika.