bluuebunny/crossref_metadata_2025 huggingface dataset:
Metamizole as a Rare Cause of Drug-Induced Liver Injury
Authors: Preveden Nevena , Liechti Matthias E , Oettl Tobias , Erb Stefan
Published: May 2022

Drug-induced liver injury (DILI) is a heterogenous entity with a wide range of pathogenetic mechanisms and clinical manifestations. DILI is a diagnosis of exclusion. Metamizole (dipyrone) is an analgesic increasingly used in Europe, but there is limited information on its adverse effects. We report the case of a 56-year-old man with acute fever, malaise and general deterioration. Onset of symptoms occurred 12 hours after intake of metamizole for shoulder pain. The patient’s medical history was remarkable for three episodes of an inflammatory syndrome with hepatitis of unknown aetiology during the previous 3 years. However, retrospective enquiry showed each episode was preceded by metamizole intake shortly before symptom onset. Relevant differential diagnoses such as infection, vasculitis, autoimmune or metabolic diseases were excluded. Liver biopsy was compatible with DILI. Discontinuation of metamizole led to rapid clinical improvement and normalization of liver transaminases. Metamizole is a very rare and poorly known cause of DILI with only a few published case reports in the literature. Careful medical history taking is important to identify the causative agent. Prompt recognition and discontinuation of the drug is crucial. Patients must be informed to avoid this medication in future.
Intermediate Care Facilities for Individuals With Intellectual Disabilities: Does Ownership Type Affect Quality of Care?
Authors: Morantz Alison , Ross Leslie
Published: May 2022

Because many large, state-owned Intermediate Care Facilities for Individuals With Intellectual Disabilities (ICF/IIDs) have closed or downsized, their average size has fallen markedly, as has the number that are publicly owned. We probe the relationship between ownership type and four measures of care quality in ICF/IIDs. Data on deficiency citations suggest that for-profits underperform other ownership types, although data on complaints show no clear pattern. Meanwhile, data on staffing ratios and restrictive behavior management practices, based mostly on facility self-reports, generally tell the opposite story. Our results lend some credence to concerns regarding inadequate care in for-profit ICF/IIDs, while underscoring the importance of requiring ICF/IID operators to report more comprehensive, longitudinal data that are less prone to error and reporting bias.
Locally controllable 2D/3D mixed display and image generation method
Authors: Li Qiang , Deng Huan , Yang Cuini , He Wei , Zhong Feiyan
Published: May 2022

In this paper, a locally controllable two-dimensional (2D)/ three-dimensional (3D) mixed display system and corresponding image generation method are proposed. The proposed system is mainly composed of a collimating backlight module (CBM) and a light control module (LCM). The CBM provides collimating polarized light. The LCM modulates a part of the collimating polarized light to form point light sources for 3D display and the other part to form scattered light sources for 2D display. The 2D and 3D display states can be locally controlled by using a pixelated mask loaded on a polarization switching layer. In addition, a corresponding image generation method is proposed. According to observer’s demand, the parallax image is divided into target image area and residual image area by using deep learning matting algorithm, and a 2D/3D mixed light field image with full parallax 3D target image and high-resolution 2D residual image is generated. We developed a prototype based on the proposed locally controllable 2D/3D mixed display structure and generated two sets of 2D/3D mixed light field image with different target objects and residual objects from the same parallax images. The experimental results demonstrated the effectiveness of our proposed system and the corresponding image generation method. High-resolution 2D image and full parallax 3D image were displayed and locally switched in the experimental system.
Spatial filtering of Zeeman sub-states in an atomic fountain
Authors: Wang Xiaolong , Sun Gewen , Cheng Bing , Wu Bin , Wang Helin , Wang Zhaoying , Wang Jing , Chen Chunlin , Wu Liming , Chang Shaohua , Tong Junze , Ma Rongrong , Feng Yafei , Xie Wenbin , Lin Qiang
Published: May 2022

In an atomic fountain, atoms in motion can be spatially separated into discrete Zeeman sub-states by magnetically induced Stern-Gerlach effect. With resonant light pulses acting as a shutter, specific states are selected for subsequent experiments. Such separation-selection process in atomic optics is the analogue of a spatial filter in physical optics which selects and purifies the modes of light. This technique is demonstrated by injecting a pulsed current in a circular coil around a vertical atomic fountain, separating the pre-cooled Rubidium atoms by a distance of centimeters in between, and filtering each single sub-state with block pulses. The filtered atoms after the process is highly purified in the desired sub-state. The apparatus of the atomic spatial filter is adaptable in atomic optics and can be integrated into the high-vacuum chamber of an atomic fountain.
Tunable angle-selective optical transparency induced by photonic topological transition in Dirac semimetals-based hyperbolic metamaterials
Authors: Wang Qin , Zhang Liwei , Cai Xiaolin , Cencillo-Abad Pablo , Ou Jun-Yu
Published: May 2022

The tunable angle-selective transparency of hyperbolic metamaterials consisting of various multilayers of Dirac semimetal and dielectric materials are theoretically and numerically studied in the terahertz range. Three stack configurations are considered: alternating, sandwiched, and disordered. It is found that the proposed structures exhibit strong optical angular selectivity induced by photonic topological transition for transverse magnetic waves. Interestingly, the topological transition frequency can be flexibly modulated by changing the Fermi energy, temperature, and the releasing time of the Dirac semimetal, as well as the thickness ratio of the dielectric and semimetal layers. It is also noticed that the angular optical transparency properties are independent of the order of the proposed structure even in alternating/disordered/random configurations if the total thickness ratio of the semimetal to dielectric are the same, which makes the properties particularly easy to realize experimentally. The proposed hyperbolic metamaterial structures present a promising opportunity for wavefront engineering, offering crucial properties for applications in private screens, optical detectors, and light manipulation.
Multi-target free-space laser communication system based on a rotating double prism with an RF signal beacon
Authors: Peng Tao , Tao Min , Ding Changchun , Li Yingzhi , Chen Bosong , Wang Duoqiang , Yu Siyao , Li Xueyan , Song Junfeng , Gao Fengli
Published: May 2022

Traditional free-space laser communication systems use beacon and signal lights for target detection and alignment. However, these approaches are inaccurate owing to signal dispersion errors. To overcome this difficulty, we propose a new method using transient radio frequency (RF) signals to achieve highly accurate target detection and alignment. To validate the feasibility of our proposed method, we built an experimental multi-target space-laser communication system based on a rotating double prism and applied it to achieve multi-target space-laser communication. The results demonstrate the efficiency of the proposed method to capture multi-target positions in the field of view using wireless RF signals and a rotating double prism. In addition, we show that the system is capable of rapid scanning and accurate pointing as well as establishing a one-way stable communication with multiple targets. When the target is 36 cm away, the pointing accuracy of the system motor is less than 0.8°, the pointing time is 1.2 s, and the average pointing lateral error is 0.666 mm.
Rigorous calibration of homodyne detection efficiency for continuous-variable quantum key distribution
Authors: Zou Mi , Mao Yingqiu , Chen Teng-Yun
Published: May 2022

We propose a rigorous calibration method for homodyne detection efficiency, which combines all the factors that affect detection efficiency to calibrate together through the actual homodyne detection. With this method, the transmittance converted from electronic noise in the one-time calibration method of the shot noise can be attributed to the detection inefficiency. Thus, a trusted detection noise-free model for continuous-variable quantum key distribution (CV-QKD) can be established, which simplifies the calibration of shot noise while having the same performance as the trusted detection noise model. We demonstrate this calibration method with a balanced detector based on a transimpedance amplifier. Experimental results show that detection efficiency will be overestimated if the integration factor of the detector is overlooked. The overestimation of the detection efficiency leads to an underestimation of modulation variance and excess noise when the modulation variance is monitored by the balanced detector, which opens security loopholes. Our method may prove a necessary method in the calibration of detection efficiency for CV-QKD.
Liquid crystal-based wide-angle metasurface absorber with large frequency tunability and low voltage
Authors: Deng Guangsheng , Hu Hualong , Mo Haisheng , Yin Zhiping , Lu Hongbo , Hu Minggang , Li Jian , Yang Jun
Published: May 2022

A tunable metasurface absorber (MA) based on polymer network liquid crystal is introduced in this paper. Despite the well-designed unit cell patterns, the proposed MA can achieve both large frequency tunability and wide-angle stability. Compared with traditional liquid crystal-based metasurfaces, the measured results suggest that the recovery time of the proposed structure was reduced by half. By applying an external voltage on the top electrode of the liquid crystal layer from 0 to a saturation voltage of 10 V, the absorption peak of the MA can be tuned from 112.7 GHz to 102.2 GHz, with a maximum frequency tunability of 9.3%, which is significantly higher than other proposed liquid crystal-based metasurfaces. Moreover, the proposed tunable absorber can maintain absorption greater than 90% with incident angles reaching up to 60° for both transverse electric and transverse magnetic polarizations. This design provides an efficient way for developing low-power consumption terahertz devices with large frequency tunability and wide-angle stability.
Dual-wavelength and double-field-of-view quantitative phase microscopy using a Fresnel bi-prism
Authors: Jafarfard Mohammad Reza
Published: May 2022

We present a novel stable quantitative phase measurement technique for extending the imaging area sensing with the capability of recording two wavelengths in a single shot. For this purpose, each wavelength is separated into three beams using a Fresnel bi-prism and they interfere in the CCD camera by a simple optic alignment. The final pattern created in the camera with the six beam contained both wavelengths information that their field of view is extended two times. The feasibility of this technique is experimentally demonstrated by dispersion measurement of silica beads using two wavelengths image of two different areas of silica beads with a single image sensor.
Bodies becoming art: Using a Deleuzian approach to explore the bodies and health of gay men
Authors: Joy Phillip , Numer Matthew , Kirk Sara , Aston Megan , Goldberg Lisa , Rehman Laurene
Published: May 2022

The ways gay men navigate socially constructed body tensions are explored through a post-structural lens. Nine self-identifying gay men in Canada used photovoice to create images that expressed their beliefs, values and practices about their bodies. Participants took part in semi-structured interviews to discuss the meanings of their images. Three discursive considerations were created from the analysis of both interviews and the photographs. Participants attempted to create bodies aligned with the dominant body ideals for gay men but, in doing so, often suffered from emotional harm that negatively shaped their health and well-being. Some participants, however, through the process of creating their bodies were able to find new connections and new understanding of their bodies. They were able to find new ways of being outside the rigid body ideals set before them. Through the post-structural lens of the research, participants’ bodies can be conceptualized as bodies becoming art.
O Papel da Educação na Superação da Crise Socioambiental: uma Reflexão a Partir de Antônio Gramsci
Authors: Freitas Luciane Albernaz de Araujo , Freitas André Luís Castro de
Published: May 2022

É possível compreender que a problemática ambiental possui limites amplos e complexos e deve ser entendida como uma crise socioambiental que perpassa a totalidade das dimensões da sociedade, estando diretamente relacionada com a lógica do modelo civilizatório vigente. A partir desse entendimento, tendo como objetivo caminhar na direção de alternativas que possibilitem a continuidade da vida na terra com padrões socioambientais dignos para a humanidade, sem polarizações entre pobres e ricos, é que se busca, tendo como referencial o materialismo histórico e dialético, sobretudo no pensamento de Antônio Gramsci, evidenciar a importância da educação para a superação do bloco histórico capitalista.
Leituras de Mundo em uma Escola na Floresta: Meio Ambiente e Educação Ambiental entre educandos e educadores de uma Reserva Extrativista
Authors: Gomes Diego Ferreira , Valdanha Neto Diógenes , Platzer Maria Betanea
Published: May 2022

O presente artigo, resultado de estudo de caso, visa a retratar uma investigação acerca de concepções de Meio Ambiente (MA) apresentadas por educandos e educadores dos anos finais do Ensino Fundamental de uma escola pública localizada na Reserva Extrativista Lago do Cuniã, no estado de Rondônia. Foi também investigado o discurso dos professores acerca de suas práticas de Educação Ambiental (EA). O instrumento de coleta de dados mais explorado foi o questionário, aplicado a 24 alunos e 04 professores. A análise dos dados evidencia que nas concepções de MA dos discentes estão as noções de “natureza” e “recurso”, mas também idiossincrasias que precisam ser consideradas, respeitadas e valorizadas. Os docentes tiveram predominantemente uma concepção de MA como “meio de vida” e apontaram relevância nas práticas de EA, tendo seus relatos sido centralizados em um caráter pragmático.
The Complete Analytical Solution of the TDOA Localization Method
Authors: Hubáček Petr , Veselý Jiří , Olivová Jana
Published: May 2022

This article is focused on the analytical solution of a TDOA (Time Difference of Arrival) localization method, including analysis of accuracy and unambiguity of a target position estimation in 2D space. The method is processed under two conditions - sufficiently determined localization system and an overdetermined localization system. It is assumed that the TDOA localization system operates in a LOS (Line of Sight) situation and several time-synchronized sensors are placed arbitrarily across the area. The main contribution of the article is the complete description of the TDOA localization method in analytical form only. It means, this paper shows a geometric representation and an analytical solution of the TDOA localization technique model. In addition, analyses of unambiguity and solvability of the method algorithm are presented, together with accuracy analysis of this TDOA technique in analytical form. Finally, the description of this TDOA method is extended to an overdetermined TDOA system. This makes it possible to determine and subsequently optimize its computational complexity, for example increase its computational speed. It seems that such a description of the TDOA localization technique creates a simple and effective tool for technological implementation of this method into military localization systems.
Evaluation of Steel and Tungsten Carbide Cobalt (WC 8Co) 5.56 x 45 mm Caliber Projectile Penetration into Silicon Carbide (SiC) Experiment and Numerical Simulation
Authors: Basyir Abdul , Bura Romie Oktovianus , Lesmana Denny , Antika Lucia Dwi
Published: May 2022

This study aims to evaluate WC-8Co as a substitution material in a standard steel core projectile commercially produced by PT Pindad (Persero). The enhanced performance of 5.56 x 45-millimeter ammunition after the addition of WC-8Co hard metal was evaluated in terms of penetration into a silicon carbide (SiC) target. Numerical simulations and analysis of the ballistic impact of WC-8Co on ceramic targets were verified by experimental data. The results show that front core substitution in SS109 bullets from steel (Pindad standard) to WC-8Co resulted in 1.5 times greater DoP. Although projectiles with steel (Pindad standard) as the front core have a muzzle velocity higher than those using WC-8Co, they have a lower kinetic energy than the latter. In addition, WC-8Co cemented carbides also displayed higher crater and residual velocity on SiC targets; around 1.8 and 1.3 times higher, respectively. These findings demonstrate the potential use of WC-8Co for development as front core material to improve the penetration of projectiles into ceramic armour.
Relación entre las estrategias de memorización y la producción oral en inglés
Authors: Arcila Cardona Juliana , Muñoz Henao Tatiana , Cano Vásquez Lina María
Published: May 2022

En este artículo se busca establecer relaciones entre las estrategias de memorización usadas por estudiantes de 9 a 13 años de dos instituciones educativas oficiales de Medellín (Colombia) y su producción oral en inglés como lengua extranjera. La investigación se orientó desde el enfoque cuantitativo, se propuso un estudio correlacional de las variables definidas y su diseño fue cuasiexperimental. Se usó un test de valoración al principio y al final del trabajo que se administró a un grupo control y a otro experimental, y los datos recabados se analizaron a través del paquete estadístico t de Student para evaluar la diferencia de medias. Los resultados permitieron concluir que sí existe relación entre las variables estudiadas (las estrategias de memorización y la producción oral en inglés) ya que la implementación de actividades que apuntan a mejorar dichas estrategias promovió el desarrollo de habilidades de producción oral en inglés como lengua extranjera en los sujetos de estudio.
Acerca de la gestación de nuevos héroes en tiempos de pandemia: una lectura de la nueva realidad social
Authors: García-Dussán Éder
Published: May 2022

Esta charla, presentada en el marco de la lección inaugural 2021 de la Maestría en Pedagogía de la Lengua Materna de la Universidad Distrital, abordó las formas de reconstrucción mediática de la realidad local del Paro Nacional del 2021, sucedido entre abril y junio en varias ciudades del país. Para aproximar una respuesta a esto, se acudió a la teoría y metodología que proyectan los estudios del discurso en su versión crítica de Van Dijk, Butler, Kress, Van Leeuwen y otros; y en la microsociología propuesta por Erving Goffman y su técnica del detalle interaccional. Los resultados muestran que hubo un declive de los símbolos de autoridad personificados en figuras históricas de poder, permitiendo concluir que los nuevos rostros del gran padre absoluto, al decir del historiador Pierre Legendre, fueron reemplazados por un símbolo paterno múltiple y acuoso, que tomó forma a través de una escritura palimpséstica y de superposición efímera.
A comparative analysis of road and rail freight transport through the Republic of Serbia from the aspect of external costs
Authors: Petrović Nikola , Jovanović Vesna , Nikolić Boban , Pavlović Jovan , Mihajlović Jelena
Published: May 2022

Transport causes significant external effects that have a very harmful impact on the environment, human health, but also the economy. The costs of these external effects are not borne directly by those who caused them, but by other road users (congestion, accidents) and society as a whole (environmental pollution costs). This results in making wrong decisions in the transport market, which further leads to an inefficient use of available resources and loss of social welfare. The purpose of this paper is a comparative analysis of negative external costs arising from freight road and rail transport. The main goal of the paper is to quantify the external costs caused by two different modes of freight transport, based on the characteristics of the transport vehicles and the characteristics of the goods being transported, as well as the length of the goods transport. The road and rail freight transport through Serbia will be chosen as the case study.
A partially overdetermined problem in domains with partial umbilical boundary in space forms
Authors: Guo Jinyu , Xia Chao
Published: May 2022

In the first part of this paper, we consider a partially overdetermined mixed boundary value problem in space forms and generalize the main result in [11] to the case of general domains with partial umbilical boundary in space forms. Precisely, we prove that a partially overdetermined problem in a domain with partial umbilical boundary admits a solution if and only if the rest part of the boundary is also part of an umbilical hypersurface. In the second part of this paper, we prove a Heintze–Karcher–Ros-type inequality for embedded hypersurfaces with free boundary lying on a horosphere or an equidistant hypersurface in the hyperbolic space. As an application, we show an Alexandrov-type theorem for constant mean curvature hypersurfaces with free boundary in these settings.
Evaluation of a pneumatic tube system carrier prototype with fixing mechanism allowing for automated unloading
Authors: Märtens Cora M. , Schöpfel Juliane , Bollmann Stefan , Hannemann Anke , Zylla Stephanie , Dahl Mathilde Borg , Gauß Friederike , Schedl Josef , Nauck Matthias , Petersmann Astrid
Published: May 2022

Objectives

A carrier prototype by Aerocom® (Schwäbisch Gmünd, Germany) for pneumatic tube systems (PTS) is able to transport 9 blood tubes which are automatically fixed by closing the lid. In this study, we examined the influence of the transport on blood sample quality using the carrier prototype comparing to courier transport and a conventional carrier (AD160, Aerocom®).

Methods

Triplicate blood samples sets (1 lithium heparin, 1 EDTA, 1 sodium citrate) of 35 probands were split among the transportation methods: 1. courier, 2. conventional carrier, and 3. carrier prototype. After transport 51 measurands from clinical chemistry, hematology and coagulation were measured and compared.

Results

Overall, 49 of the investigated 51 measurands showed a good concordance among the three transport types, especially between the conventional carrier and the carrier prototype. Focusing on well-known hemolysis sensitive measurands, potassium showed no statistically significant differences. However, between courier and both carrier types lactate dehydrogenase (LDH) and free hemoglobin (fHb) showed statistically significant shifts, whereas the clinical impact of the identified differences was neglectable. The median concentration of fHb, for example, was 0.29 g/L (18 µmol/L), 0.31 g/L (19 µmol/L) and 0.32 g/L (20 µmol/L) for courier transport, conventional carrier and carrier prototype, respectively. These differences cannot be resolved analytically since the minimal difference (MD) for fHb is 0.052 g/L (3.23 µmol/L), at this concentration.

Conclusions

The carrier prototype by Aerocom® is suitable for transportation of diagnostic blood samples. The overall workflow is improved by decreasing hands-on-time on the ward and laboratory while minimizing the risk of incorrectly packed carriers.
Effect of post-compaction heating on characteristics of microcrystalline cellulose compacts
Authors: Gharaibeh Shadi F. , Obeidat Wasfy M. , Al-Zoubi Nizar
Published: May 2022

Compacts of microcrystalline cellulose were prepared at applied compression pressures of 21, 32, 43, 53, and 64 MPa. Compacts were subjected to elevated temperatures of 125°C, 150°C, and 175°C according to a 5-min heating program. The effect of these thermal treatments on compact volumes, densities, porosities, tensile strengths, and weight loss was determined. There was no change in the volumes of the compacts due to thermal treatments in most of the conditions. However, the densities of the compacts decreased while the porosities increased as a consequence of weight loss. Moreover, there was no difference (p > 0.05) between the tensile strengths of the compacts without heat treatment and those subjected to heat treatment in most of the conditions. This was indicative of the preservation of the magnitude of the interparticulate bonds in the compacts. Weight loss of the compacts was affected by the heat treatment temperature and their porosities.
The acoustics of plosives and the formation of prosodic structure in Polish
Authors: Wojtkowiak Ewelina , Schwartz Geoffrey
Published: May 2022

The aim of this acoustic study of voiced and voiceless word-initial plosives is to establish the nature of the relationship between prosodic positions, accent, and segmental phonetics in Polish. Four different acoustic parameters were investigated (VOT, pitch, F1, and preceding vowel’s duration). The results show rather modest effects of prosodic position. The findings are interpreted with reference to the prosodic typology posited in the Onset Prominence representational framework (OP), in which prosodic domains are not imposed from above but rather are formed according to opposing mechanisms of ‘submersion’ and ‘adjunction’. The findings support the claim that Polish belongs to the latter category, in which only modest effects of position are expected.
A compact S-band band-pass filter with ultra-wide stopband
Authors: Xu Qian-kun , Zhang Zhong-nan , Wu Xiao-hua , Wang Jue-zhe , Peng Lin
Published: May 2022

A novel compact S-band band-pass filter (BPF) with ultra-wide stopband is presented. The proposed filter mainly consists of three parts, a novel crossed resonator, parallel-coupled microstrip lines, and defect ground structures (DGSs). The resonator is constructed by three capacitive open stubs, while a defect is etched in the center stub to eliminate high frequency harmonics. The parallel-coupled microstrip lines are mainly used to improve the passband and the roll-off rate (the ratio of height to width of the filter transition band). And the DGSs are utilized to improve the stopband performances. The proposed BPF has the merits of compactness, good insertion loss and good stopband characteristic. The measured 3 dB operating band is 1.80–4.03 GHz (76.5% at f
0 = 2.92 GHz), The upper out-of-band suppression was better than 20 dB for the frequency up to 20 GHz (6.33f
0), and the upper roll-off rate reaches 75.59 dB/GHz.
Phosphorus removal from aqueous solution by adsorption using wetland-based biochar: Batch experiment
Authors: Xu QiaoLing , Wang Li , Tan Minxia , Wang Xiaolei , Li Jiajie , Geng Hejun
Published: May 2022

This article experiments wetland-based biochar as an effective adsorbent for phosphorus removal. In this experiment, four common wetland plants, canna (C), umbrella palm (U), bamboo reed (B), and Thalia dealbata (T), were used as the main raw materials. Twelve kinds of biochar (C300, C500, C700, U300, U500, U700, B300, B500, B700, T300, T500, and T700) were obtained at three pyrolysis temperatures (300°C, 500°C, and 700°C). The results show that canna (C) and umbrella palm (U) are more suitable as raw materials for phosphorus removal using biochar. If bamboo reed (B) and Thalia dealbata (T) are used as raw materials for phosphorus removal using biochar, there is a greater risk of phosphorus release. With the increase of pyrolysis temperature (700°C > 500°C > 300°C), there is an increasing trend of phosphorus adsorption effect. The theoretical maximum adsorption capacity of C700, U700, and C500 was 39.24, 7.08, and 7.26 mg P·g−1 at an initial concentration of 50 mg·L−1 phosphorus, respectively. The theoretical adsorption capacity of C700 (Q
max = 39.24 mg P·g−1) was much higher than that of the general modified adsorption materials. It also has a larger tolerance range to pH (3–11). The results of kinetic model fitting showed that the adsorption mechanism of C700, U700, and C500 on phosphorus can be better simulated by intra-particle diffusion and Elovich model, and the adsorption mechanism includes surface adsorption and intra-particle diffusion. The fitting of isothermal adsorption model showed that Langmuir–Freundlich equation is more suitable for the description of adsorption characteristics of C700, U700, and C500, and the fitting coefficient R
2 is 0.9928, 0.9949, and 0.9897, respectively. It indicates that the adsorption of phosphorus on C700, U700, and C500 has a balance of uniform and nonuniform surface, and monolayer and multilayer adsorption could occur. The results from this work demonstrated that the biochar obtained from canna at 700°C has good adsorption and phosphorus removal potential without modification, and it can be used as the preferred biochar for phosphorus removal of high concentration with large pH changes. In the final validation experiment, the phosphorus removal rate of C700 was up to 77.4% on the treatment of actual phosphorus containing wastewater.
Quantitative visualization study on the physical movement and gastric emptying of diced carrot particle in a transparent rat stomach-duodenum model
Authors: Feng Jiajun , Wu Peng , Chen Xiao Dong
Published: May 2022

In this study, a transparent soft-elastic silicone rat stomach model was prepared to visualize the gastric movement and emptying of one individual diced carrot in a dynamic in vitro rat stomach system. The influences of the viscosity of solution medium, the pattern of gastric peristalsis and the extraction rate of the emptying pump on the location and gastric residence time of the carrot particle were examined. A proper medium viscosity could promote the emptying of the carrot particle. Compared to the combined actions of plate and roller, gastric residence time of the carrot particle was reduced from 32.3 to 19.8 min under the single plate compression. This time was also shortened from 34.8 to 12.3 min when the extraction rate of emptying pump was changed from 100 mL/min to 400 mL/min. Knowledge gained from this work is unique and may provide new insights for optimizing biomimic gastrointestinal models.
Typical strength of asphalt mixtures compacted by gyratory compactor
Authors: Rasool Dina A. , Hilal Miami M. , Fattah Mohammed Y.
Published: May 2022

Design of asphalt mixes and quality testing is influenced by the laboratory compaction procedure. Laboratory specimens must be manufactured in a way that suitably resembles field compaction for a performance test to give reliable mechanical properties. The internal structure of the mixture, which is referred to in this article as the spread of aggregate and air voids, provides the basis for the simulation. Gyratory compaction uses a kneading effort to produce cylindrical specimens. The goal of the present article is to determine the required strength for asphalt mix compaction of 40–50 per surface. This look was achieved with three distinct types of filler material and two kinds of sand. The asphalt mixture’s compressibility was tested. By adding the cumulative energy expended during gyratory specimen compaction to the compression data, the force applied to the sample during gyrations may be calculated. The relation between the number of gyrations and forces demonstrates pressure resistance. The measured fore force vs number of gyrations for combinations containing limestone, cement, and fly ash as fill materials was presented. The force required to compact the six bituminous materials was found to be influenced by the filler content. As the number of gyrations increases, its compaction properties change until it achieves a steady state. Except for the asphalt–cement mixture, compaction strength in mixes containing river sand requires less strength than compaction strength in mixes containing crushed sand.
Cell-free DNA in sports medicine: implications for clinical laboratory medicine
Authors: Neuberger Elmo W.I. , Simon Perikles
Published: May 2022

Background

Physical activity can have a strong impact on the concentration of several promising candidate biomarkers, including cell-free DNA (cfDNA).

Content

This narrative review describes the current understanding of how physical strain leads to increases of cfDNA and discusses how this interferes with attempts to standardize cfDNA analysis in clinical laboratory medicine.

In general, all cells of the human body can release DNA, whereas neutrophils are described as the major source releasing cfDNA under resting conditions. Event at low physical load, cfDNA is rapidly released by immune cells. We recently, identified neutrophils as the major cell-type contributing to cfDNA increases during acute exercise. Both, endurance and strength training can affect the signal-to-noise ratio of liquid biopsy (LB) analysis, affecting the clinical validity between minutes up to several days. Furthermore, we discuss why physical distress of various kinds in a perioperative cancer setting can improve or compromise signal-to-noise. Therefore, physiological events including, but not limited to, activation of blood cells can provoke pre-analytical challenges for ultra-sensitive detection of cfDNA in LB settings.

Outlook

We discuss why future attempts to standardize liquid biopsy may therefore profit from a deeper understanding of the physiological release mechanisms of cfDNA.
Dialectical Abnormality? Jewish Alienation and Jewish Emancipation between Hegel and Marx
Authors: Yigit Emir
Published: May 2022

Karl Marx’s “On the Jewish Question” (1844) has fueled discussions around his early intellectual development as a Young-Hegelian thinker as well as debates about an allegedly distinct form of anti-Semitism native to Left-Hegelian and later to left-thinkers in general, Jewish and non-Jewish alike. In this essay, I argue that Marx’s assessment of contemporary Judaism is motivated by an underappreciated criticism of Hegelian historiography. Surveying the genealogy of the Hegelian treatments of Judaism between Hegel and Marx, I distinguish Marx’s intervention as a reaction to non-materialistic teleological historiography. This historiography assumes dialectical movement and demands practical change from those considered foreign to the movement. In contrast, this article suggests that Marx’s primary target is the belief that Judaism has been sublated into Christianity, that the abnormality lies not in Judaism’s historical persistence, but in the Christian pretense that the material contradictions Judaism was a response to have been overcome. Against the teleological nature of all renditions of Hegelian historiography, including Marx’s later historical-materialism, his “On the Jewish Question” weaponizes a hitherto unrecognized anti-teleological argument against the assimilationist views it responds to, of the kind that should evoke Nietzschean genealogy.
Crystal structure of 3-(3-bromophenyl)-1′,3′-dimethyl-2′H,3H,4H-spiro[furo[3, 2-c]chromene-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H) tetraone, C22H15BrN2O6
Authors: Jiang Dong-Li , Fan Lian-Lian , Yin Peng , Liang Di , Li Rui
Published: May 2022

C22H15BrN2O6, monoclinic, P21/c (No. 14), a = 5.1760 (5) Å, b = 17.5652(19) Å, c = 21.734(2) Å, β = 94.690(3) °, Z = 4, V = 1969.3(3) Å3, R

gt
(F) = 0.0569, wR

ref
(F
2) = 0.1206, T = 170 K.
Hydrothermal synthesis and crystal structure of catena-poly[diaqua-bis(μ2-4-[(4-pyridinylmethyl)amino]benzoato-κ2
N:O)cobalt(II)]–1,2bi(4-pyridyl)ethene–water (1/1/1), C50H50N8O8Co
Authors: Guang-Zhen Liu , Li Ya-Di
Published: May 2022

C50H50N8O8Co, triclinic, P

1
‾

$\overline{1}$

, a = 9.2920(4) Å, b = 11.3648(5) Å, c = 11.9954(4) Å, α = 96.478(3)°, β = 104.766(3)°, γ = 103.901(4)°, V = 1168.40(8) Å3, Z = 1, R

gt
(F) = 0.0393, wR

ref
(F
2) = 0.1431, T = 293(2) K.
The crystal structure of poly[aqua-(μ2-4,4′- bis(imidazolyl)biphenyl-κ2
N:N′)-(μ2-3-nitrobenzene-1,2-dicarboxylato-κ2
O:O′)]copper (II) hydrate, C26H21N5O8Cu
Authors: Li Gui-Lian , Liu Meng-Ni , Du Gao-Jing , Zhang Jin-Yuan
Published: May 2022

C26H21N5O8Cu, monoclinic, P21/c (no. 14), a = 17.2262(10) Å, b = 7.3474(3) Å, c = 21.1086(11) Å, β = 111.498(6)°, V = 2485.8(2) Å3, Z = 4, Rgt
(F) = 0.0629, wRref
(F
2) = 0.1433, T = 293(2) K.
Housing and health in vulnerable social groups: an overview and bibliometric analysis
Authors: Chen Junhua , Hao Shuya , Wu Ying
Published: May 2022

Previous studies have confirmed that poor living conditions can lead to a wide range of health problems. However, in the context of the COVID-19 pandemic, vulnerable groups in unstable housing are more susceptible to disease. This study aims to systematically examine the housing and health problems of vulnerable groups using a bibliometric approach to explore how housing causes health problems, types of health illnesses, and coping strategies. It is found that the poor housing mechanism, persistent inequalities, and poor housing environments have a significant impact on the health of vulnerable groups. Therefore, the government must make concerted efforts across all sectors to ensure that the housing and health care needs of vulnerable groups are improved, and that housing security standards and related policies are improved; targeted safety plans are formulated with community as the carrier, taking into account the characteristics of vulnerable groups; and new information technology is widely used to provide medical convenience for vulnerable groups. It is hoped that the research in this paper can arouse social attention to the health of vulnerable groups and improve their health from the perspective of housing, so as to point out the direction for solving the housing health problems of vulnerable groups in the future.
Necessary and sufficient conditions in optimal control of mean-field stochastic differential equations with infinite horizon
Authors: Roubi Abdallah , Mezerdi Mohamed Amine
Published: May 2022

We consider an infinite horizon optimal control of a system where the dynamics
evolve according to a mean-field stochastic differential equation and the
cost functional is also of mean-field type. These are systems where the
coefficients depend not only on the state variable, but also on its marginal
distribution via some linear functional. Under some concavity assumptions on
the coefficients as well as on the Hamiltonian, we are able to prove a
verification theorem, which gives a sufficient condition for optimality for a
given admissible control. In the absence of concavity, we prove a necessary
condition for optimality in the form of a weak Pontryagin maximum principle,
given in terms of stationarity of the Hamiltonian.
Preparation and characterization of a graphene hybridizing polyurethane damping composite
Authors: Ma Chi , Zhang WeiLin , Wang LianHui , Guo Zhuo , Jiang Yan , Shan Yi , Chen JingYi , Wang Ying , Sin Lee Tin
Published: May 2022

A graphene hybridizing polyurethane/polyethyl methacrylate (GR-PU/PEMA) damping composite was synthesized using the sequential interpenetration method. The effects of the graphene content and the microphase separation structure on the damping properties, thermal stability, and mechanical properties have been studied in detail. The dynamic mechanical analysis indicated that graphene could improve the damping peak value of PU/PEMA, and the microphase separation structure could be beneficial for broadening the damping temperature range. The damping peak (tan σ
max) of PU/PEMA hybridizing with 0.5 wt% graphene reached 0.82, and the temperature range of the loss factor (tan σ ≥ 0.3) was expanded to 88.3°C. Analysis of scanning electron microscopy, transmission electron microscopy, and small-angle X-ray scattering reveals that graphene is uniformly dispersed in the polymer matrix, and the composite with interpenetrating polymer network (IPN) shows more microphase separation structures. Fourier transform infrared analysis indicated that there is strong interaction between graphene and IPN matrix. Furthermore, the addition of graphene improved the mechanical properties and thermal stability of composites.
Neuropathy and pain after breast cancer treatment: a prospective observational study
Authors: Bennedsgaard Kristine , Grosen Kasper , Attal Nadine , Bouhassira Didier , Crombez Geert , Jensen Troels S. , Bennett David L. , Ventzel Lise , Andersen Inge S. , Finnerup Nanna B.
Published: May 2022

Objectives

Neurological complications including pain are common after treatment for breast cancer. This prospective study investigated the symptoms, intensity and interference of chemotherapy-induced peripheral neuro-pathy. (CIPN) in the feet and hands compared to surgery- and radiation-induced neuropathy in the breast and upper arm.

Methods

Consecutive patients referred to surgery for breast cancer were included in a prospective study and completed a questionnaire at baseline and a follow-up questionnaire and interview after one year. CIPN was assessed with the CIPN20 questionnaire and the Michigan Neuropathy Screening Instrument questionnaire (MNSIq). Pain intensity was rated on a numeric rating scale (NRS, 0–10).

Results

In total 144 patients were included, of which 73 received chemotherapy. At one-year follow-up, symptoms of polyneuropathy were more common in patients treated with chemotherapy. Tingling or numbness in the feet in those treated/not treated with chemotherapy was reported by 44 (62%) and 15 (21%), respectively. Pain was present in 22 (30%) and 10 (14%), respectively. Pain in the area of surgery was reported by 66 (46%). Although less common, pain in the feet in those treated with chemotherapy was rated as more intense and with more daily life interference than pain in the surgical area (NRS 5.5 (SD 1.9) vs. 3.1 (SD 1.9).

Conclusions

Neurological complications including pain following surgery and chemotherapy represent a burden to breast cancer survivors. In those who had received chemotherapy, pain in the feet was less common than pain in the surgical area, but pain in the feet was more intense and had a higher interference with daily life. Our study emphasizes the need for either baseline data or a control population for improved estimation of the presence and severity of CIPN and pain from questionnaires.
ADAPTOR PROTEIN RUK/CIN85 IS INVOLVED IN THE GLUCOSE METABOLISM REPROGRAMMING IN BREAST CANCER CELLS
Authors:   Palladin Institute of Biochemistry of NAS of Ukraine, Kyiv, Bekala M. I. ,   Taras Shevchenko National University of Kyiv, Kyiv
Published: May 2022

Aim. This study aimed to investigate the changes in glucose metabolism in mouse 4T1 breast adenocarcinoma cells with different levels of Ruk/CIN85 expression. Methods. We used 4T1 cells with stable overexpression (subline RukUp) or knockdown (subline RukDown) of Ruk/CIN85, as well as corresponding vector control sublines Mock and Scr. Cells were cultured in the complete RPMI-1640 medium under standard conditions. mRNA expression levels were estimated by RT2-PCR, enzymes activities were measured by spectrophotometric and/or fluorometric assays. Results. Analysis of mRNA expression of glucose metabolism-related genes in RukUp and RukDown cells revealed that glycolysis genes are preferentially overexpressed in RukUp cells, and downregulated in RukDown cells. Thus, RukUp cells were characterized by significantly overexpressed Slc2a1, Gck, Aldoa, and Ldha, while in RukDown cells these genes were either down regulated or not changed. However, the expression of TCA (tricarboxylic acid) cycle enzyme Mdh2 increased dramatically (by 7,8 times) in RukDown cells. In detail, we observed statistically significant changes in the activity of all studied enzymes in RukUp cells (increase by 1,5-1,9 times for glycolysis enzymes and G6PD, and decrease by 1,33-1,69 times for TCA enzymes). However, in RukDown cells we did not find any significant changes in glycolysis enzymes activities, but activities of mitochondrial IDH3 and MDH2 were elevated by 1,65 and 1,59 times, respectively. Conclusions. The results obtained indicate that adaptor protein Ruk/CIN85 is involved in the metabolic reprogramming during breast cancer progression. High level of Ruk/CIN85 expression is associated with potentiation of the Warburg effect.
ADAPTOR PROTEIN Ruk/CIN85 PARTICIPATES IN THE METABOLIC CONTROL OF HUMAN BREAST ADENOCARCINOMA MCF-7 CELLS
Authors:   Taras Shevchenko National University, Kyiv, Korshun R. S.
Published: May 2022

Aim. To determine the role of Ruk/CIN85 in the control of breast adenocarcinoma cells metabolism, we performed systemic analysis of the activity levels/content of key enzymes/components of glycolysis and oxidative phosphorylation using as a model the weakly invasive human breast adenocarcinoma MCF-7 cell line (Mock); and its sublines with stable overexpression (G4 subline) and reverse down-regulation (G4vir subline) of the adaptor protein. Materials and methods. MCF-7 cells were cultured in the complete DMEM medium under standard conditions. Enzymes activity, content of metabolites and protein in cell extracts and the conditioned cell culture medium were estimated by spectrophotometric and fluorometric assays. Results. First of all, biochemical indexes of aerobic glycolysis, activity levels of some key glycolytic enzymes and metabolites were evaluated. A significant increase in the activity of these enzymes, aldolase A (ALDOA) and lactate dehydrogenase A (LDHA), was found in G4 cells compared to Mock by 1.3 and 1.6 times, respectively. In addition, in the conditioned medium of G4 cells, an increase in lactate content by 1.5 times compared with the control was found, which corresponded to a change in LDHA activity. Knockdown of Ruk/CIN85 expression level in G4 subline resulted in a significant decrease of these parameters compared to G4 cells, ALDOA – 4 times, LDHA - 1.4 times, and lactate production - 2.5 times. It should be noted that in G4vir cells, LDHA activity returned to level of control cells, while ALDOA activity and lactate content additionally decreased by 3 times and 1.6 times, respectively. Therefore, the observed changes in the intensity of glycolysis in MCF-7 sublines positively correlate with the expression level of adaptor protein studied. To assess the metabolic status of mitochondria, the level of activity of the Krebs cycle enzyme, NAD-dependent malate dehydrogenase (MDH2), the catalyst of last stage of the cycle, was determined. A 2-fold decrease in MDH2 activity was found in the MCF-7 G4 subline relative to control Mock cells, as well as an increase in this index by 2.4 times in G4vir cells to control values. Unlike glycolysis, we observed the opposite pattern with respect to the intensity of Krebs cycle reactions depending on the expression level of Ruk/CIN85. Conclusions. Use of limited proteolysis technique as the source of additional information for computer modeling allowed us to propose an improved model of 3D-structure of fibrinogen αC-regions. This model takes into account the behavior of αC-regions in the physiological condition and contributes to the general knowledge about fibrinogen structure.