bluuebunny/crossref_metadata_2025 huggingface dataset:
Intracranial hypertension management in spontaneous skull base meningoencephaloceles
Authors: Poczos Pavel , Cihlo Miroslav , Zadrobílek Karel , Jandura Jiří , Čelakovský Petr , Adamkov Jaroslav , Kostyšyn Roman , Česák Tomáš
Published: October 2022

Spontaneous meningoencephaloceles are often associated with cerebrospinal fluid leak and intracranial hypertension. There is a data scarcity concerning the need for insertion of a cerebrospinal diversion device in these situations. Therefore, we provided an analysis of our patients with spontaneous skull base meningoencephaloceles (MEC) whether their definitive surgical treatment requires management of elevated intracranial pressure (ICP) or not. Retrospective evaluation and data collection of 10 subjects with spontaneous MEC was held. Among others, attention was paid to measuring of ICP, prior interventions, treatment with acetazolamide, characteristics for long term elevated ICP, etc. Our own indications for cerebrospinal fluid (CSF) diversion and use of postoperative external lumbar drain (ELD) underwent analysis as well. The sphenoid region was the most common location of MEC. CSF leak was diagnosed in all subjects. The most common graphical signs of elevated ICP were empty sella and arachnoid pits, both of which were presented in 90% of cases. A lumbar puncture with opening pressure measurement was performed in 7 patients. Ventriculoperitoneal shunt insertion was indicated in 4 cases prior to and in two cases after skull base repair. Two postoperative CSF leaks were managed with ELD and subsequent shunt installation. Spontaneous MECs are often associated with CSF leak. The ICP assessment should be a standard of care to ensure MEC operative repair success. Insertion of a CSF diversion device must be considered where direct or indirect signs of ICH are presented.
Cryptocurrency Curated News Event Database From GDELT
Authors: Gadi Manoel Fernando Alonso , Sicilia Miguel Ángel
Published: October 2022

Event studies in general rely on having a high-quality curated database of events. In this paper we introduce CryptoGDelt2022, a news event dataset extracted from the Global Database of Events, Language and Tone (GDELT) containing more than 243 thousands cryptocurrency related news events between the 31st of March 2021 and 30th of April 2022. The dataset is enriched with supervised machine learning scores for Relevance, Sentiment and Strength. Supervised Relevance Score measures how related to Cryptocurrency the topic is using news web scrapped from Yahoo in general and from the Cryptocurrency part of the site, after a comparison of approaches; Latent Dirichlet Allocation (LDA), BERT and Naive Bayes, Naive Bayes was chosen and the hyper-parameter tuned model reached accuracy: 97.84 % in the train set and 91.70% in the test set. Supervised Sentiment Score measures the negative, neutral or positive tone of the news, after hyper-parameter tuning, the retrained FinBERT model achieved accuracy of 92.63% in the train set and 86.11% in the test set. Supervised Strength Score measures how strong the news by using the abnormal return using Fama French 3-factor model as target output variable, after hyper-parameter tuning, the trained Naive Bayes model reached accuracy of 63.34%. The work concludes that GDELT is more reliable source of event when compared to news selected from cryptocurrency specialized websites as it presents a more balanced positive and negative number of news. All data sets and Python Jupyter Notebooks are available in the project's GitHub.
Dieulafoy's disease of the bronchus: rare but potentially fatal
Authors: Daboussi Salsabil , Kacem Marwa , Boubaker Nouha , Chaabene Mariem , Aichaouia Chiraz , Mhamdi Samira , Moatemri Zied
Published: October 2022

Background: Dieulafoy’s disease of the bronchus can cause massive and even fatal hemoptysis. Even though it is rare, it should be considered by physicians all over the world, as several cases are reported by literature.
Methods and results: We report the case of a 41-year-old man, so far in good health, presenting with massive hemoptysis. Bronchoscopy showed blood clots and a protruding lesion covered by mucosa with a white pointed cap at the entrance of the right upper lobe. Biopsies were not attempted. Embolization of bronchial artery was first realized and was not successful, with post procedure complications. Surgical intervention stopped the bleeding and pathological examination of the resected specimen confirmed Dieulafoy’s disease of the bronchus.
Conclusion: To our knowledge, this is the first case of bronchial Dieulafoy’s disease to be reported in Tunisia and North Africa. When the diagnosis is suspected, bronchoscopy biopsy should be avoided as it might lead to fatal hemorrhage. Selective bronchial artery embolization can stop the bleeding, but surgery can be required.
Dynamics of absorption and evaporation of organic solvents in carbon nanotubes-embedded wood
Authors: Kim Do-Hyun , You Seungyeol , Lee Myeung-jin , Kim Hong-Dae , Kim Gyu Tae
Published: October 2022

Wood, a hygroscopic material, is sometimes exposed to organic solvents for decoration or protection. Compared with measuring water contents, it is still quantitively challenging to estimate the degree of the absorption and evaporation of organic solvents in wood. In this work, we investigated the dynamics of absorption and evaporation of various organic solvents in the wood by monitoring a change in an electric current. To realize this, we fabricated an electrically conductive wood by embedding multi-walled carbon nanotubes (MWCNTs) into the walnut timber. Then, organic solvents such as ethanol, n-hexane, acetone, toluene, benzene, and iso-propyl-alcohol were dropped in the MWCNTs-embedded wood under controlled voltage conditions. The current was changed differently during the absorption and evaporation of the solvents in the woods. As a result, we found that polar and nonpolar solvents exhibited different degrees of absorption and evaporation in walnut wood. Acetone and n-hexane are polar and nonpolar organic solvents absorbed and evaporated rapidly in the conductive wood among organic solvents. In addition, we found that the absorption and evaporation dynamics obeyed different mathematical models. Our work paves the way to study the absorption and evaporation of organic solvents in the frame of electrically conductive wood.
LG-MLFormer: Local and Global MLP for Image Captioning
Authors: jiang Zetao , Wang Xiuxian , Zhai Zhongyi , Cheng Bo
Published: October 2022

Self-attention-based image captioning model exists visual features’ spatial information loss problem, introducing relative position encoding can solve the problem to some extent. However, it will bring additional parameters and greater computational complexity. To solve the above problem, we propose a novel local-global MLFormer (LG-MLFormer) with specifically designed encoder module Local-global Multi-Layer Perceptron (LG-MLP). The LG-MLP can capture the latent correlations between different images and its linear stacking calculation mode can reduce computational complexity. It consists of two independent local MLP (LM) modules and a cross-domain global MLP (CDGM) module. The LM specially designs the mapping dimension between linear layers to realize the self-compensation of visual features’ spatial information without introducing relative position encoding. The CDGM module aggregates cross-domain potential correlations between grid-based features and region-based features to realize the complementary advantages of these global and local semantic associations. Experiments on the Karpathy test split and the online test server reveal that our approach provides superior or comparable performance to the state-of-the-art (SOTA). Trained models and code for reproducing the experiments are publicly available at: https://github.com/wxx1921/LGMLFormer-local-and-global-mlp-for-image-captioning.
Cancer associated fibroblast-dependent and -independent invasion of cancer cells
Authors: Kondo Ryotaro , Sakamoto Naoya , Harada Kenji , Hashimoto Hiroko , Morisue Ryo , Yanagihara Kazuyoshi , Kinoshita Takahiro , Kojima Motohiro , Ishii Genichiro
Published: October 2022

Purpose
Cancer cells are known to exhibit a cancer-associated fibroblast (CAF)-dependent invasive mode in the presence of CAFs. The purpose of this study was to investigate whether intrinsic factors of cancer cells influence the CAF-dependent invasive mode of cancer cells.
Methods
We observed the dynamic movement of CAFs and cancer cells by time-lapse imaging of 2-D and 3-D collagen invasion models and evaluated the invasion modes of gastric cancer cell lines (MKN-7, MKN-45, and HSC44PE). We further examined whether modification of the invasive capacity of CAFs can alter the invasive mode of MKN-7 and HSC44PE cells.
Results
When MKN-7 and MKN-45 were co-cultured with CAFs, CAFs first invade collagen matrix followed by cancer cells (CAF-dependent invasion), whereas HSC44PE invaded collagen matrix independently of CAFs invasion. Overexpression or suppression of podoplanin in CAFs, respectively increased or decreased the invasive capacity of CAFs themselves and significantly increased or decreased the number of invading MKN-7, respectively. CAFs overexpressing a podoplanin mutant lacking the cytoplasmic domain had a significantly reduced invasive capacity compared to CAFs overexpressing wild-type podoplanin, and it also reduced the number of invading MKN-7 cells significantly. When HSC44PE and CAFs were co-cultured, changes in the podoplanin expression in CAFs similarly altered the invasive capacity of CAFs themselves, but it did not affect the number of invading HSC44PE cells.
Conclusion
These results indicate that in the presence of CAFs, there are CAF-dependent and -independent modes of cancer cell invasion, the determinants of which may depend on the intrinsic properties of cancer cells.
Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during vitrectomy
Authors: Che Danyang , Chan Zhulin , Zhou Jibo , Zhu Dongqing
Published: October 2022

Purpose: To evaluate the efficacy and safety of silicone oil (SO) as a corneal lubricant to improve visualization during vitrectomy.
Design: A retrospective, interventional, observational study.
Methods: Patients who underwent vitreoretinal surgery were divided into two groups. Group 1 was operated on with initial SO as a corneal lubricant. Group 2 was operated on with initial lactated ringer’s solution(LRS) and then replaced with SO as required. Fundusclarity was scored during the surgery. Fluorescein staining was performed to determine the damage to corneal epithelium.
Results: 114 eyes of 114 patients were included. Single SO use maintained a clear cornea and provided excellent visualization of surgical image. In group 1, the fundus clarity was grade 3 in 41/45 eyes and grade 2 in 4/45 eyes. In group 2, corneal edema frequently occurred after initial LRS use. The fundus clarity was grade 3 in 19/69 eyes, 2 in 37/69 eyes and 1 in 13/69 eyes. This difference between two groups was statistically significant. SO was applied in 29 eyes of initial LRS use with subsequent corneal edema, which eliminated the corneal edema in 26 eyes. Corneal fluorescein staining score in group 1 was 0 in 28 eyes, 1 in 11 eyes and 2 in 6 eyes, and 40, 20 and 9, respectively, in group 2. This difference between two groups was not statistically significant.
Conclusion: The use of SO as a corneal lubricant is effective and safe for preserving and improving corneal clarity and providing clear surgical field during vitrectomy.
5 cases of mirror man combined with colorectal cancer treated surgically and literature review
Authors: Chen Xiao-Qiong , Chen Wei , Yang Lin-Qing , Chen Gui-Ting , Wang Xiao-Fang , Huang Yao-Yi , Huang Mei-Jin , Tan Shu-Yun
Published: October 2022

Background
Situs inversus totalis (SIT) is a rare congenital malformation in which the viscera is positioned in the opposite direction of normal, like a mirror. The patients of SIT with colorectal cancer (CRC) requiring surgical treatment are even more rare.
Methods
From January 2013 to May 2022, the clinical data of 5 SIT patients with CRC diagnosed in the Sixth Affiliated Hospital of Sun Yat-sen University were reviewed.
Results
Five SIT patients with CRCwere all female, aged 53-76 years. One patient died of complications after surgery due to poor cardiopulmonary function; One patient presented with a recurrent lesion of the side of the urethra after surgery and was readmitted for chemoradiotherapy. One patient died of tumor recurrence after surgery and chemotherapy. One patient with IIA was indicated by pathology after operation, and no recurrence was found. No tumor recurrence was found in one patient with early pathological indication. After reviewing 17 related literatures, together with 5 cases in our hospital, the most common primary sites of tumors were the sigmoid node and ascending colon, and the median survival of patients with combined chemotherapy was longer.
Conclusions
It is safe and feasible to perform surgery on the SIT patients with CRC after the preoperative examination and evaluation.
Association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging
Authors: Seki Yasuhiro , Aczel Dora , Torma Ferenc , Jokai Matyas , Boros Anita , Suzuki Katsuhiko , Higuchi Mitsuru , Tanisawa Kumpei , Boldogh Istvan , Horvath Steve , Radak Zsolt
Published: October 2022

Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging is strongly influenced by environmental and life-style factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNAmethylation based estimation of TL (DNAmTL) and DNA methylation based biomarkers of aging of master rowers (N = 151) and sedentary subjects (N = 90), aged between 37–85 years. It was found that the TL inversely correlated with chronological age, while no gender dependent difference was found. We could not detect association between telomere length and VO2max, vertical jump and working memory by RT-PCR method, while these physiological test results showed correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there is no powerful beneficial effects of exercise or physiological fitness on telomere shortening, however the degree of DNA methylation is associated with telomere length. DNAm based estimation of TL shows stronger relationships with physiological functions than RT-PCR measured data.
Fitting Concentric Elliptical Shapes Under General Model
Authors: Al-Sharadqah Ali , Piga Giuliano
Published: October 2022

The problem of fitting concentric ellipses is a vital problem in image processing, pattern recognition, and astronomy. Several methods have been developed but all address very special cases. In this paper, this problem has been investigated under a more general setting and two estimators for estimating the parameters have been proposed. Since both estimators are obtained iteratively fashion, several numerical schemes are investigated and the best initial guess is determined. Furthermore, the constraint Crame Rao lower bound for this problem is derived and it is compared with the variance of each estimator. Finally, our theory is assessed and validated by a series of numerical experiments.
Study on Rural Sewage Ecological Treatment System in China
Authors: WAN Ajun , Chen Hongling , Tu Runqiu , Qi Xiaolei , Wang Jiucheng
Published: October 2022

The rapid development of Chinese rural economy has led to an increasingly serious environmental pollution in rural areas, especially the random discharge of sewage to pollute water sources and endanger the health of villagers. This article combines the existing resources and needs in rural areas to study and establish a rural sewage ecological treatment system involving septic tanks, interception wells, improved integrated treatment equipment and waterlogging ponds, and takes Liutian Village in Shaanxi Province as an example. The system is based on the functional and practical principles from the rainwater and sewage collection system to drainage system, treatment system and recovery system. Ecological, economic and effective solutions are adopted in all aspects after comparative analysis. The input cost of the whole treatment system is relatively low, the effect is better and the functions are more. The sewage treated by this system meets the national emission standards. For rural sewage treatment, the system has good economic, social and ecological value and has broad application and promotion prospects.
WITHDRAWN: A PCA-EM hybrid model based on the spatial pattern of ecological vulnerability and correlation study
Authors: Wu Siqi , Kang Hou , Li Xuxiang
Published: October 2022

Ecological vulnerability reflects the ability of an ecosystem to resist adverse factors, and has become a global research hotspot. As an energy city in China and a city in the hinterland of the Loess Plateau, the study of Taiyuan's ecological vulnerability is of great importance. Most of the studies had used individual models, whose indicator weights were subject to large human factors or large compression of indicator information. In this study, an indicator evaluation system was developed based on the pressure state response (PSR). In order to overcome the shortcomings of a single model, a hybrid data processing model based on principal component analysis-entropy method (PCA-EM) was constructed in this study to study the ecological vulnerability of the area and compared with the principal component analysis model (PCA). Meanwhile, this study used Pearson correlation coefficients for analysis to evaluate the model performance and the influence of each parameter on ecological vulnerability. The research results illustrated that from 2000 to 2019, the EVI of Taiyuan showed a trend of first increasing and then gradually decreasing, indicating that it’s ecology was gradually improving. By comparing PCA method and PCA-EM method, the PCA-EM model could more objectively and reasonably evaluate the ecological environment of the region. Most of the indicators were negatively correlated with EVI, the highest correlation coefficient between per capita arable land and EVI. Furthermore, this study proposed a hybrid model to explore the ecological vulnerability status and influencing factors of the study area, providing an idea for data processing model.
Impact of WACC on Firm Profitability: Evidence from Food and Allied Industry of Bangladesh
Authors: Rahman Farhana
Published: October 2022

The research paper aims to analyze the underlying relationship in between the profitability and cost of funds of a firm. A total of twelve companies were selected as a sample for this study which are listed in Dhaka Stock Exchange under Food and Allied Industry. A panel data set of 15 years from 2005 to 2019 was used to conduct the necessary analysis. In this paper, Return on Asset (ROA) is used as the accounting criteria of profitability. WACC is the independent variable while Firm Size, Firm Age and Firm Leverage are used as control variable for the study. Fixed Effects Panel Regression Model is used to analyze the dataset. The result of the analysis shows that WACC is negatively related with the profitability measure and this relationship is significant. The study has potential to be replicated by other industries like textile, cement, pharmaceutical & chemical, fuel & power, tannery etc.
Research on the Impact of Face Threat and Perceived Sincerity on Online Shopping Service Recovery Satisfaction
Authors: Wei Jiahua , Li Lei
Published: October 2022

Online shopping has become a part of people's life, but the services failure has made online stores face huge challenges. It is urgent to explore the impact mechanism and strategies of its service recovery. Based on such psychological theories as face threat, perceived sincerity, consumer forgiveness and relationship strength, this study collected research data through scenario experiments and conducted empirical research. The results show that: Face threat and perceived sincerity have a negative and positive impact on consumer forgiveness, respectively; consumer forgiveness has a positive impact on service recovery satisfaction; relationship strength plays a positive moderating effect in the relationship between consumer forgiveness and service recovery satisfaction; consumer forgiveness plays a mediating effect between related variables. This study is conducive to analyzing the impact mechanism of online shopping service recovery from the perspective of consumer psychology, so as to provide theoretical basis and operational guidance for online stores to conduct scientific service recovery, improve online stores’ service recovery ability, and promote the healthy development of online shopping industry.
Bridging the Gap?
Authors: Haller Miriam
Published: October 2022

Die Topografie des Alters wird durch die Pandemie einschneidend verändert: Die Schutzmassnahmen gegen eine Ansteckung mit Covid 19 bewirken eine vorher nie dagewesene räumliche Distanz zwischen den Generationen. Schliesslich treffen die Regulierungen des sogenannten Social Distancing die als besonders vulnerabel eingeschätzte Gruppe der Über 50-Jährigen besonders stark. Auf diese Situation haben Kulturgeragoginnen, Kulturgeragogen und Kulturschaffende schnell mit der Entwicklung alternativer Angebote der kulturellen Altersbildung reagiert, die dem Gebot räumlich-körperlicher Distanz Rechnung tragen. Es wurden vielfältige mediale Räume, Brücken und Kanäle konstruiert, um die Mauern und Altersgrenzen zu überwinden, die die pandemiebedingten Massnahmen neu errichtet haben. In meinem Beitrag analysiere ich aus kulturtopologischer Perspektive (spatial turn) im Anschluss an Michel Foucaults Begriff der Heterotopie (Foucault 1967/1990, vgl. auch Haller 2011/2020) anhand von drei Fallbeispielen die medialen Kanäle und die durch sie formierten Subjektpositionen sowie das Potenzial dieser kulturgeragogischen Projekte in Zeiten von Corona, Resonanzräume und heterotopische Reflexionsräume zu bilden.
Impact of human resource management on organizational performance in Nigeria: Nigeria breweries Kaduna plc as a case study
Authors: Jacob Byyiyet Josiah , Ishaya Yusha’u , Bajama Shem Yunusa
Published: October 2022

Over the last decade, much research has been conducted in the field of human resource management (HRM) and its associations with organizational performance. Prior studies have found substantial positive evidence for statistical associations between HRM and organizational performance. The purpose of this study is to investigate the relationships between HRM practices and firm performance. This study examines the relationships among HRM practices and firm performance. The researcher adopted the descriptive survey design. Primary data was sourced through the instrument of questionnaire. The total of 13 department which comprises of 305 employees which the sample size needed to carry out our survey was 75 in order to achieve 90% precision from the sample. The research study is drawn scientifically using the stratified random sampling technique. The findings revealed among others HRM has a great impact on organizational performance and the conclusion is a stimulus to Nigeria breweries through a well-coordinated HRM practices, value added to company’s production processes and the contribution made by each employee have more effect on the results obtained by the organisation. This finding leads to the conclusion that HRM can bring about a higher organisational performance for firm. The researcher recommended among others that HRM should endeavor to have a well-structured effective organizational performance in order to achieve the set up objectives and in order to improve employees efficiency and effectiveness towards achieving the organisational goals, the appraisal period should be more frequent probably every quarterly and various motivational instrument should be introduce to entice employees to perform better and these would go a long way in fostering an understanding of multicultural work climate and enhancing the building of a truly agile Nigeria breweries, Kaduna.
Social listening through sentiment analysis of Twitter data: a case study of Paytm IPO
Authors: Mehta Meera , Arora Shivani , Gupta Shikha , Jhulka Arun
Published: October 2022

Purpose. Microblogging sites are being used by people across the globe to share their opinions and to express sentiments for everything in real time. Through social listening, companies analyse the sentiments to assess the way forward, and the researchers use it to analyse the trend or an event and give forward-looking recommendations. The objective of the paper is to analyse the sentiments of people relating to Paytm IPO which can be used to predict the way forward. Design/methodology/approach. The study attempts sentiment analysis. For this purpose, QSR NVIVO 12, the qualitative analysis tool was used to retrieve the tweets from the Twitter website. NCapture was installed for this purpose. Post data cleaning, stemming, query augmentation and classification, the Twitter data was analysed. Findings. The sentiments around the IPO of Paytm have been negative and sarcastic. The extremely negative tweets were near twice the number of extremely positive tweets. Practical implication. The study can help an investor in evaluating the investment that they might be planning in the given company. For the company, whose IPO is being considered, an analysis of the sentiments around the IPO can help in taking corrective measures, if the sentiment is negative, towards reputation building. Originality/value. The study is an original contribution to the extant literature in the field of sentiment analysis.
An examination of factors affecting tourists’ destination choice: empirical evidence from Bangladesh
Authors: Mim Mahabuba Khanm , Hasan Mahide , Hossain Afzal , Khan Yusuf Hossein
Published: October 2022

The tourism industry has become an important sector that has a substantial influence on the development of a country’s economy. One of the most significant benefits of tourism includes the construction and improvement of local infrastructure. Tremendous opportunities waits for Bangladesh as she has potentials to attract both local and global tourists. However, tourism and destination marketers should utilize different marketing tactics to content and retain existing customers, encourage new and prospective ones. The research was to examine the impact of destination familiarity, destination image, safety and security, travel motivation, social media and reference groups on tourists’ destination choice in the contexts of Bangladesh. The research design of this study was descriptive. The study was used purposive sampling method. Primary and secondary data both were used. Primary data were collected through a structured questionnaire by survey method from 256 Bangladeshi tourists visiting to tourism destination using a five-point Likert scale. Statistical package for the social sciences (SPSS) 25.0 version software was used for analysis the data. It was analysed using descriptive statistics analysis, multicollinearity test, reliability analysis and multiple regression analysis. The results of the regression analysis revealed that all aspects except travel motivation had a significant and positive influence on destination choice in Bangladesh. Therefore, it is recommended that the research creates awareness among prospective tourists, investigators, academicians, government authorities, tourism businesses, politicians and all the stakehold
EPIDEMIOLOGIE DES PIQURES DE SCORPIONS AU NIVEAU DE LA REGION DE MARRAKECH
Authors:   Service Dechoquage IBN Tofail, Marrakech., Maaroufi S. , Arrass S. El ,   Service Dechoquage IBN Tofail, Marrakech., Hounain T. ,   Service Dechoquage IBN Tofail, Marrakech., Elkhayari A. ,   Service Dechoquage IBN Tofail, Marrakech.
Published: October 2022

Introduction : Le Maroc comme dautres pays dAfrique du Nord, du Proche orient et dAmerique du Sud constitue une des regions les plus touchees par lenvenimation scorpionique. Cest un veritable probleme de sante publique. Lobjectif de notre etude est devaluer le profil epidemiologique, clinique des piqures de scorpion (PS), et determiner les differents facteurs ayant une influence sur le pronostic. Afin dameliorer les mesures de prise en charge et de prevention. Materiels Et Methodes: Il sagit dune etude prospective, descriptive realisee sur une periode de 9 mois, de janvier a septembre 2019. au niveau du dechoquage de lhÃ´pital Ibn Tofail, Marrakech. On a inclus les patients adultes ages de 18 ans ou plus, ayant ete admis pour PS, et hospitalises au service de dechoquage de lhÃ´pital Ibn Tofail. Resultats : Vingt-cinq patients ont ete inclus. Lage des patients variait entre 18 et 96 ans avec une moyenne de 48,39 ans, une predominance masculine (64%), 80% des cas etaient dorigine rurale, les piqures etaient survenues la nuit dans 56%, essentiellement au niveau des parties distales des membres (44%). Soixante-huit pour cent des piqures etaient note en Juin et Juillet. 32% des patients ont ete pris en charge au-dela de la troisieme heure. 84% des patients ont ete admis au dechoquage en classe II et seulement 16% en classe III. Les signes cliniques frequemment rapportes etaient : lhypersudation (96%) et les vomissements (76%). Tous les patients ont ete pris en charge de faÃ§on symptomatique, dont 100% des patients ont reÃ§u la Dobutamine pendant 12h. Sur le plan evolutif, la duree moyenne dhospitalisation etait de 2 jours, 92% des patients ont evolue favorablement contre 8% ont ete transfere en reanimation. Conclusion: Une bonne prise en charge doit etre precoce et doit se baser sur les protocoles elabores par nos experts locaux. Sans oublier linteret de la prevention et leducation qui constitue une etape essentielle dans la strategie nationale de lutte contre les piqures de scorpions.
LE SYNDROME DE BRUGADA ET LA SCHIZOPHRENIE A PROPOS DUN CAS
Authors:   Hopital Psychiatrique Universitaire Arrazi de Sale, Faculte de Medecine et Depharmacie, UniversiteMohamed V, Rabat, Maroc., Kissa N. , Stati S. ,   Hopital Psychiatrique Universitaire Arrazi de Sale, Faculte de Medecine et Depharmacie, UniversiteMohamed V, Rabat, Maroc., Boukdir A. ,   Hopital Psychiatrique Universitaire Arrazi de Sale, Faculte de Medecine et Depharmacie, UniversiteMohamed V, Rabat, Maroc., Belbachir S. ,   Hopital Psychiatrique Universitaire Arrazi de Sale, Faculte de Medecine et Depharmacie, UniversiteMohamed V, Rabat, Maroc., Ouanass A. ,   Hopital Psychiatrique Universitaire Arrazi de Sale, Faculte de Medecine et Depharmacie, UniversiteMohamed V, Rabat, Maroc.
Published: October 2022

Les maladies cardiovasculaires (MCV) contribuent de maniere significative a la morbidite et a la mortalite des patients atteints de schizophrenie, le syndrome de Brugada est une cause importante mais meconnue de mort subite du cÃ‚Âœur. Il est plus frequemment observe dans la schizophrenie que dans la population generale [1] Le syndrome de Brugada est une maladie arythmique hereditaire caracterisee par la presence dun sus-decalage ST courbe (au moins 2 mm), avec une onde T negative sur les derivations ECG precordiales droites de lECG (schema de Brugada de type 1). La prevalence mondiale estimee est de 0,10 %2 et limportance de ce syndrome reside dans son association avec la mort cardiaque subite chez les jeunes [2] Ce syndrome presente une transmission autosomique dominante de mutations dans le gene du canal sodique cardiaque, qui joue un rÃƒÂ´le important dans la pathogenie de ce syndrome. Les mutations dans le gene SCN5A representent la plupart des cas [2] Elle est liee a au moins lun des criteres suivants : syncope ou arrÃƒÂªt cardiaque, fibrillation ventriculaire ou tachycardie ventriculaire polymorphe, des antecedents familiaux de type 1 de Brugada, de mort subite avant 45 ans, ou mort nocturne [1]. Jusqua 4 % des patients souffrant de schizophrenie sont atteints du type 1 de Brugada-ECG, compare a une prevalence estimee a 0,05% dans la population generale. Cela suggere une plus grande prevalence du syndrome de Brugada dans la schizophrenie. Cela pourrait expliquer en partie le risque accru de MCV dans la schizophrenie [1].
Stages of radiation monitoring on the territory of the Tula region affected in consequence of the Chernobyl NPP accident
Authors: Boldyreva V. V. , Ovcharova V. N.
Published: October 2022

More than half of the Tula oblast territory was contaminated following the accident at the Chernobyl nuclear power plant. This article describes the stages of radiation hygiene monitoring of objects in the habitat in the Tula region impacted by radioactive contamination. Information is given on changes in radioactively contaminated areas at different periods after the accident. An assessment is made of the radiological situation at the initial “iodic” period of the accident, the subsequent “cesium” period, and at the current stage. A description is given of work done by the oblast’s state sanitary and epidemiological service based on radiation monitoring results for reducing the radiation exposure of the population at different stages of supervision. Information is supplied on high levels of gamma background up to 35 mkSv/h during the “iodic” period. Tabulated data are supplied on exceeding the tentative maximum permissible level of iodine-131 content in dairy products produced in Plavski district, the most contaminated area in the region. Data are given on laboratory tests on food products for total beta activity in 1986-87 and the frequency of exceeding the permissible level of cesium-137 content during 1986. The above permissible content of radionuclides in food products was registered only in 1986 due to surface contamination of plants, while in wild mushrooms this took place as late as 2004. Currently, the proved content of cesium-137 and strontium-90 in food products is determined only by the radio-chemical method. A table is supplied showing results of radio-chemical research on major dose contributing food products from 2010 to 2021. The article supplies a table with numeric values of annual average effective doses of radiation sustained by the population of settlements located in the Chernobyl radioactively contaminated zone during 1986 through 2021. The dose of the population’s exposure to the Chernobyl radiation since 1994 does not exceed 1 mSv/year. In 2021, the population’s annual effective dose in 98.3% of settlements amounted to less than 0.2 mSv/year.
OS CURRÍCULOS DOS PRIMEIROS CURSOS DE QUÍMICA DA UNIVERSIDADE DE COIMBRA E DE UNIVERSIDADES BRASILEIRAS
Authors: Fonseca Vanessa , Rodrigues Sérgio , Pazinato Maurícius
Published: October 2022

THE CURRICULUMS OF THE FIRST CHEMISTRY COURSES AT UNIVERSITY OF COIMBRA AND BRAZILIAN UNIVERSITIES. The study of History of Education is very important to teacher education because it allows reflections and greater criticality about their own teaching practice and professional condition. The purpose of this research was to identify similarities between the curriculum of Chemistry courses of University of Coimbra (UC), National School of Chemistry (ENQ) and School of Engineering of Porto Alegre (EEPA) at the beginning of the 20th century seeking to identify possible influences of UC in the structuring and curriculum of the first Brazilian higher education Chemistry courses. The results showed more similarities regarding the structure between UC and ENQ, while there were greater correspondences in the curricular activities between UC and EEPA. Finally, it was not possible to identify confluences in the curriculums of the courses over the decades since there was a divergence between the models of organization of the higher education in the countries under study.
MICROSCÓPIOS ALTERNATIVOS CONSTRUÍDOS A PARTIR DE MATERIAIS DE BAIXO CUSTO
Authors: Borges Guilherme , Borges Pedro , Cardoso Cássia , Cerqueira Daniel
Published: October 2022

ALTERNATIVE MICROSCOPES BUILT USING LOW-COST MATERIALS. This work aims to compare the construction of magnification devices. Details of the construction and use of microscopes based on webcam and smartphone are presented, using software for image processing. It is also presented the construction of microscopes using drops of different liquids as magnifying lens, a compound microscope, and a water-drop projector. Magnified images obtained with each device are presented, and the different microscopes are compared. The results obtained from the use of these alternative instruments confirm that alternative microscopes are instruments of easy reproducibility, enabling the amplification of samples for a more detailed observation of the object of interest.
Oxygen Reduction Reaction on Pt-Y/C Catalysts: Activity and Long-Term Stability Study
Authors: da Silva Gabriel Christiano , Perez Joelma
Published: October 2022

Pt-Y/C catalysts were prepared by a modified formic acid method and their structural characteristics and activity for oxygen reduction reaction (ORR) were evaluated. X-ray diffraction analysis showed that no alloy was formed between the metals and X-ray photoelectron spectroscopy (XPS) experiments showed that yttrium is presented as Y2O3, Y(OH)3 and Y-O-Pt species. CO stripping voltammetry and in situ X-ray absorption spectroscopy confirmed the interaction between Pt nanoparticles and yttrium species. The Pt-Y/C 7:3 material showed the higher specific activity (103 μA cmPt -2) for ORR. Following repetitive potential cycling, the activity for the ORR of the Pt-Y/C 7:3 catalyst declined in a similar proportion to the Pt/C material. Transmission electron microscopy analysis after stability for both catalysts showed that Pt/C particle size slightly increased and that for Pt-Y/C 7:3 remained the same. XPS made in ultrathin catalyst layer, agreeing with energy-dispersive X-ray spectroscopy analysis, revealed that the intensities of the Y 3d peaks were suppressed relative to the initial one and that yttrium in the form of Y2O3 and Y(OH)3 were dissolved, while the species Y-O-Pt still remain in the catalyst, maintaining the higher activity.
Comparative analysis of long-term precipitation trends and its implication in the Modjo catchment, central Ethiopia
Authors: Zena Besha Kokeb , Demissie Tamene Adugna , Feyessa Fekadu Fufa
Published: October 2022

Understanding trends and variability of precipitation is essential to improve water resources utilization as well as agricultural activities. This study aims to investigate the spatiotemporal trends and variability of rainfall in the Modjo watershed, central Ethiopia. The Mann-Kendall trend (M–K) test, innovative trend analysis (ITA) and Sen's slope estimator were used to determine temporal trends, while the inverse distance weighted interpolation technique was adopted to visualize the spatial trends in time series. The result showed that complex patterns of rainfall variability that range from 16 to 59%, 18 to 63%, and 50 to 90% for the annual, summer, and spring seasons, respectively was observed over the study watershed. The result also indicated that significant trend (p < 0.05) in annual rainfall was detected only in 28.6% and 42.9% of the stations under the M-K test and ITA method, respectively, which indicates relatively more significant trends are displayed by the ITA method than the M–K test. At the seasonal scale, positive trends have been more dominant in the summer season (Z > 0, SITA > 0), whereas negative trends (Z < 0, SITA < 0) were detected in the spring season. Comparatively, the ITA method is found to be robust and allows more detailed trend analysis results using graphical illustrations for extreme events. The study concludes that the increasing and decreasing trends in summer and spring rainfall patterns could have implications leading to an increase in extreme events and lower agricultural productivity, respectively. The result suggests the need for planning effective adaptation strategies at the regional and local scales.
Böbrek iskemi ve reperfüzyon hasarında kreatin monohidrat desteğinin etkileri
Authors: HELVACIOĞLU Fatma , GÖKTAŞ Tayfun , ALTUNKAYNAK-CAMCA Hande Ozge , ŞİRİNOĞLU Tuğçe
Published: October 2022

Amaç; Böbrek nakli ya da cerrahi girişimler sırasında gelişebilen iskemi ve reperfüzyon hasarı etkisini hücrelerdeki enerji metabolizmasının bozulması ve oksidatif stresin artmasına yol açarak gösterir. Popüler sporcu destek ürünü olan kreatin monohidrat endojen bir bileşiktir. Hücrelerin enerji metabolizmasını etkileyerek oksidatif stresi azalttığı ve antioksidan etki gösterdiği bilinmektedir. Böbrekte deneysel olarak oluşturulan iskemi reperfüzyon hasarı sonrasında artan oksidatif strese ve yapısal düzeyde izlenen hasara karşı kreatin monohidratın olası etkisinin değerlendirilmesi hedeflenmiştir.Yöntemler: Çalışmada Sprague Dawley (270-380 gr) türü 24 adet erkek sıçan kullanıldı. Sıçanlar rastgele dört gruba ayrıldı: Grup 1: Kontrol grubu, Grup 2: İskemi/ Reperfüzyon grubu, Grup 3: İskemi/ Reperfüzyon +Kreatin monohidrat (Kreatin 2 g/kg/gün), Grup 4: Kreatin monohidrat (2 g/kg/gün) olarak düzenlendi. Grup 2 ve Grup 3’teki sıçanlara intraperitoneal anestezi sonrası 45 dakika boyunca sol renal arterin klemplenmesiyle renal iskemi oluşturuldu ve 45. dk’nın sonunda klemp uzaklaştırıldıktan sonra sol böbreğin parlak kırmızı renge ulaşması reperfüzyonun sağlanması olarak kabul edilerek karın ön duvarı kapatıldı. Grup 3 ve Grup 4’deki sıçanlara 3 gün süresince kreatin monohidrat (2g/kg/gün) distile su içinde çözülerek gavaj yoluyla uygulandı. Reperfüzyondan 72 saat sonra genel anestezi altında kardiyak kan, sol böbrek dokuları alındıktan sonra sakrifiye edildiler. Böbrek dokuları ışık ve elektron mikroskopta değerlendirildi. Plazma örneklerinde total oksidan ve antioksidan stres parametreleri ölçümlendi.Bulgular: İskemi ve reperfüzyon modelinde ince yapı düzeyinde glomerüler kapillerlerdeki belirgin eritrosit stazı saptandı. Bunun yanında glomerüller endotelin ve podositlerin hücre bütünlüğünün korunamadığı izlenirken proksimal tübüllerdeki hücrelerde de şişme sonucu tübül lümenin tıkandığı görüldü. Kreatin uygulanan gruplarda total antioksidan seviyesinin istatistiksel olarak anlamlı ölçüde artması yeniden yapılanma sürecinin pozitif yönde ilerlediğinin göstergesi olarak yorumlandı.Sonuç: Sonuç olarak uygulanan yöntemden kaynaklandığı düşünülen eritrosit stazı nedeniyle dolaşımın tam olarak sağlanamadığı ve buna bağlı olarak kreatin monohidrat desteğinin yapısal düzeyde belirgin olumlu etki gösteremediği düşünüldü.
Influence of Quercetin Pretreatment on Pharmacokinetics of Warfarin in
Rats
Authors: Ahmad Ejaz , Jahangir Muhammad , Ismail Muhammad Akhter , Afzal Hafsa , Bano Shehar , Shamim Rahat , Bukhari Nadeem Irfan
Published: October 2022

Background:

Warfarin (WAR) is an anticoagulant with a narrow therapeutic index and
is principally metabolized by CYP3A4 and CYP2C9 enzymes. The inhibitors of these enzymes
may alter the systemic exposure to WAR. Quercetin (QUE), a bioflavonoid, may modify the bioavailability
of drugs used concurrently by inhibiting CYP3A4, CYP2C8, CYP2C9, CYP1A2, and Pglycoprotein
(P-gp).

Objective:

The current study scrutinized the influence of QUE on WAR pharmacokinetics in rats.

Method:

QUE was orally administered to animals for 14 consecutive days, followed by WAR as a
single oral dose on the 15th day in the pre-treatment group. The co-administration group received a
single dose of QUE and WAR concomitantly. Only carboxymethylcellulose (CMC) 0.5% was administered
as a vehicle to control group.

Result:

In the pre-treated group, WAR’s Cmax was increased by 30.43%, AUC0-∞ by 62.94%, and t1/2 by
10.54%, while Cl decreased by 41.35%, relative to control. In co-administered animals, WAR’s Cmax increased
by 10.98%, AUC0-∞ by 20.20%, and t1/2 by 8.87%, while Cl declined by 16.40%.

Conclusion:

QUE alters the pharmacokinetics of WAR, warranting possibly WAR dose adjustment
after confirmatory clinical investigations, specifically in patients with thrombotic disorders
and a pre-treatment history of QUE or its product.
Growth Hormone Excess: Implications and Management
Authors: Dhaneshwar Suneela , Shandily Shrishti , Tiwari Vatsalya
Published: October 2022

Acromegaly is described as the oversecretion of growth hormone (GH) and, subsequently,
insulin-like growth factor 1 (IGF-1), ascribed in most cases to a pituitary adenoma. This
disease presents a progressive disfigurement, along with other systemic manifestations, which altogether
diminishes the quality of life in the patients. Prolonged exposure to abnormally high levels
of GH and IGF-1 levels results in cardiovascular, cerebrovascular, and pulmonary dysfunction
which overall produces a fall in life expectancy. Timely diagnosis and further treatment decreased
the mortality rate of the patients and showed an improvement in the quality of life. Surgical procedures,
advanced radiation therapy tools, and the availability of pharmacological compounds that act
on pituitary growth hormone-producing cells have enabled an improved approach to treating the
disease. Pharmacological treatment is currently an important management option, and it may also
be the first-line treatment in patients with acromegaly who do not benefit from or are ineligible for
first-line surgical procedures. From its inception until 2021, we used a comprehensive search strategy
on Medline/PubMed, Scopus, Embase, Web of Science, and the Cochrane Library electronic
databases. All human research articles and review articles published in English were considered for
the review. In this review, we describe the clinical implications and management of patients with
acromegaly, consisting of scientific improvements underlying the developing understanding of
pathogenesis and diagnosis, associated comorbidities and mortality rate with the disease, and major
improvements in the treatment of the disease, along with novel strategies including quality of life
and patient-reported outcomes.
Smoking Status Association with Intention to Vaccination against Coronavirus Disease-2019
Authors: Al-Rawashdeh Sami , Mrayyan Majd T. , Hayajneh Audai A.
Published: October 2022

Objectives:

This paper aimed to examine the association between smoking status and the intention to get the COVID-19 vaccine in a convenience sample of 226 Jordanian adults.

Methods:

Cross-sectional data on smoking status, the intention of vaccination, attitudes toward- and fear of COVID-19, and perceived susceptibility and severity of COVID-19 were collected. Descriptive comparative and correlational bivariate and multivariable statistical analyses were used.

Results:

Most subjects were female and single, with a mean age of 26.8 years. About 27.9% were smokers. Smokers had significantly higher mean scores on the intention of vaccination than non-smokers (p=.049). On regression analysis, smoking status was not a significant predictor, but higher scores on attitude toward and fear of COVID-19 were the only significant predictors of the intention for vaccination.

Conclusion:

Although smokers appear to have a higher intention to get the COVID-19 vaccine, variables other than smoking status, such as attitudes towards and fears of COVID-19 may influence people's decisions and should be appropriately addressed. Smoking's effect on the intention of vaccination with COVID-19 warrants further study.