bluuebunny/crossref_metadata_2025 huggingface dataset:
Protocol for assessment of the efficiency of CRISPR/Cas RNP delivery to different types of target cells
Authors: Tyumentseva Marina A. , Tyumentsev Aleksandr I. , Akimkin Vasiliy G.
Published: November 2021

Background

Delivery of CRISPR/Cas RNPs to target cells still remains the biggest bottleneck to genome editing. Many efforts are made to develop efficient CRISPR/Cas RNP delivery methods that will not affect viability of target cell dramatically. Popular current methods and protocols of CRISPR/Cas RNP delivery include lipofection and electroporation, transduction by osmocytosis and reversible permeabilization and erythrocyte-based methods.

Methods

In this study we will assess the efficiency and optimize current CRISPR/Cas RNP delivery protocols to target cells. We will conduct our work using molecular cloning, protein expression and purification, cell culture, flow cytometry (immunocytochemistry) and cellular imaging techniques.

Discussion

This will be the first extensive comparative study of popular current methods and protocols of CRISPR/Cas RNP delivery to human cell lines and primary cells. All protocols will be optimized and characterized using the following criteria i) protein delivery and genome editing efficacy; ii) viability of target cells after delivery (post-transduction recovery); iii) scalability of delivery process; iv) cost-effectiveness of the delivery process and v) intellectual property rights. Some methods will be considered ‘research-use only’, others will be recommended for scaling and application in the development of cell-based therapies.
Tendering a Tactile Tectonic: Discovering and Deploying Architecture’s DNA
Authors: Reynolds John M.
Published: November 2021

In a current academic architectural design culture often characterized by parametricism, cybernetics, and virtual reality, architectural design’s visceral and haptic dimensions have assumed an inferior position in architectural design ideation and process. Whether through intentional dismissal or benign neglect, the design process pursued in many undergraduate architectural programs has assumed an occularcentric modality. Students ideate in a weightless, immaterial, design landscape of simulation, devoid of the shifting qualities of color, light and shadow, the nuance of olfactory and tactile cues, and material resonance. Rather than advance a nostalgic, anti-digitally mediated position, the design practices described here deploy haptic means to tender a design process that advances a tactile tectonic grounded in the DNA or patterns of human experience and nature.
Presentation
Authors: Falcón Luis Álvarez , Umbelino Luís António
Published: November 2021

Este breve texto presenta el Dossier monográfico dedicado a la posteridad de la denominada Conferência de Coimbra, el congreso internacional de estudios fenomenológicos dedicado a la obra de Ricardo Sánchez Ortiz de Urbina que se celebró en la Facultad de Letras de la Universidad de Coimbra, contando con la presencia del célebre filósofo español.
Nota de Abertura
Authors: Reis Carlos
Published: November 2021

O número 11 da Revista de Estudos Literários que agora se publica corresponde a um desafio que, não sendo novo entre nós, tem uma história relativamente recente. Fazem parte dessa história episódios (felizmente já remotos) que bem evidenciam a forma como os contextos históricos e políticos podem afetar o desenvolvimento dos estudos literários. E não só deles, evidentemente.
José de Urcullu, mediador cultural ibérico
Authors: Míguez Ana Belén Cao
Published: November 2021

A reconstrução das relações interculturais ibéricas ao longo da história deve contemplar os agentes de mediação que, como o liberal espanhol José de Urcullu (falecido em 1852), conformam os “ninguéns” ou “quase-alguéns” (Magalhães, 2007) empenhados em promover tal comunicação entre culturas e literaturas, nomeadamente a estabelecida pela via da tradução. Pese a sua relevância e interesse como mediador, e pese o capital sociocultural e político de que chegou a ser detentor este exilado espanhol radicado no Porto, Urcullu continua a ser uma figura desconhecida, ou pelo menos insuficientemente conhecida nos nossos dias. O presente trabalho destina-se a tentar resgatá-lo desse esquecimento que o torna hoje invisível. Com esse objetivo, serão reveladas algumas atividades em que se envolveu enquanto mediador intercultural ibérico e, interrogando-nos sobre as suas motivações, tentar-se-á reconstituir o itinerário biográfico de Urcullu, dando a conhecer os resultados de uma investigação inédita à volta deste multifacetado autor e (auto)tradutor.
Perspetivas críticas sobre os estudos ibéricos. Cristina Martínez Tejero E Santiago Pérez Isasi (Eds.). Veneza: Edizioni Ca’Foscari [Biblioteca di Rassegna iberistica], 2019 317 páginas. ISBN 9788869693243
Authors: Pazos-Justo Carlos
Published: November 2021

Com origem no colóquio internacional Os estudos ibéricos a partir da periferia. Desafios epistemológicos e novos olhares nos estudos galegos, bascos e catalães (Universidade de Lisboa, 8-9 de março de 2018) e financiado pela Fundação para a Ciência e a Tecnologia, Perspetivas críticas sobre os estudos ibéricos traz treze estudos e uma introdução (em formato digital) que, segundo indicam os editores, Cristina Martínez Tejero (Universidade de Santiago de Compostela) e Santiago Pérez Isasi (Universidade de Lisboa), conformam uma abordagem em duas direções: a dos estudos ibéricos e a da análise dos casos catalão, basco e galego, de forma a “pensar a atualidade e pertinência do campo académico [dos] estudos ibéricos, bem como rever o estado das áreas de trabalho sobre os casos galego, catalão e basco” (p. 8).
Bacterial Cellulose Production in The Overripe Guava Juice by Acetobacter xylinum as A Solution to Reduce Organic Waste
Authors: Lathifah Annisa Nur , Nuryana Isa
Published: November 2021

The exploration for a new cost-effective carbon source with shorter fermentation process for high yield BC production is still needed. In this study, bacterial cellulose (BC) was synthesized by Acetobacter xylinum using overripe guava juice as a carbon source. The results showed that A. xylinum was able to grow on the overripe guava juice with different concentration and produced BC after two days incubation. In the later on, the BC is called as nata de guava. The overripe guava juice which containing reducing sugar content 23 g /L (substrate 100%) at pH 4 produced the thickest BC (1.267 cm). This study showed due to the high reducing sugar and protein contents in the overripe guava, without the addition of carbon and nitrogen from external sources, BC could be formed. Considering the huge disposal overripe guava fruit waste in Java, the present study provides an alternative methodology to synthesize BC. Besides, most importantly, this study provides a new insight to manage organic waste specifically from overripe guava fruit rather than the waste being thrown away and becoming organic waste generation. Keywords: bacterial cellulose, Acetobacter xylinum, overripe guava, organic waste
Individual tree measurements by means of digital aerial photogrammetry
Authors: Korpela Ilkka
Published: November 2021

This study explores the plausibility of the use of multi-scale, CIR aerial photographs to conduct forest inventory at the individual tree level. Multiple digitised aerial photographs are used for manual and semi-automatic 3D positioning of tree tops, for species classification, and for measurements on tree height and crown width. A new tree top positioning algorithm is presented and tested. It incorporates template matching in a 3D search space. Also, a new method is presented for tree species classification. In it, a partition of the image space according to the continuously varying image-object-sun geometry of aerial views is performed. Discernibility of trees in aerial images is studied. The measurement accuracy and overall measurability of crown width by using manual image measurements is investigated. A simulation study is used to examine the combined effects of discernibility and photogrammetric measurement errors on stand variables. The study material contained large-scale colour and CIR image material and 7708 trees from 24 fully mapped plots in Southern Finland. The results of the discernibility analysis suggest that 88–100% of the total stem volume is measurable when using multiple aerial photographs. The structure and density of the forest were found to affect discernibility. The best hit-rates when using the semi-automatic tree top positioning algorithm ranged from 77 to 100% of the visually discernible trees. Systematic underestimation of the crown width was observed and the measurability of crown width was best near the image nadir. Species classification was tested in mixed stands of Scots pine, Norway spruce, and silver birch. The Kappa-coefficients ranged from 0.71 to 0.86. The results of the simulation suggest that very high accuracy at the individual tree level cannot be expected. However, if the photogrammetric measurements are unbiased, the aggregate stand variables can be very accurate. An accurate species recognition method is needed in the mixed stands in order to achieve unbiased estimates for the small strata.
Seeking Experience in Architecture: Corporeal Attempts at Perception and Conception
Authors: Voigt Katharina , Roy Virginie
Published: November 2021

This contribution presents the proceedings from a series of transversal university projects, addressing bodily forms of knowledge concerning the perception, inquiry, and conception of architecture. It retraces the phases of different manners of investigation over a threesemester teaching cycle, addressing perceptions and experiences of architectural spaces. The proceedings of, and results from the seminar cycle are documented and framed with an introduction to the applied methods and ways of working as well as their reflection and evaluation. These varying approaches all center around the questions of how to bring body-based and incorporated knowledge concerning architectural space to awareness and how attention to sensual and corporeal ways of perception can be increased. Thus, it investigates how the spectrum of design methods in architecture can be extended in order to actively include bodily forms of knowledge in the anticipation of spatial experience in the design process. The article introduces a concept of »Architecture Imagery« as a way to include bodily ways of knowing and body-based practices in the perception and memory of lived experience and the process of architectural design.
LEARNING AL QURAN HADITH AS THE BASIC FOUNDATION OF BUILDING THE MORALE OF LEARNERS AT MI MAKLUMUL MUKMININ NW PONDOK GEDANG
Authors: Sufyan Ats-Tsauri Muhammad , Fatonah Siti
Published: November 2021

The learning of the Qur'an Hadith was carried out by the subject teacher dimadrasah Ibtidaiyah NW pondok gedang designed with a concept that emphasizes more on the moral planting of children through the habituation of simple activities in school. This research uses descriptive qualitative research with the aim of describing the concept of student moral planting through the study of the Qur'an Hadith. From the results of this research shows that the teachers of the subjects of the Qur'an Hadith in madrasah ibtidaiyah menananmkan good habituation to students diantarranya is: 1). Habituation to say greetings. 2). Read basmallah to start the lesson. 3). Get along well with relatives in class. 4). throw the trash in the trash box. 5). When going into the classroom the teacher is used and emphasizes the habit of students to say hello. 6). when leaving the classroom is also used to say hello. 7). and teach adab in speech, learning ethics, eating ethics, drinking ethics, and so on. From this habituation, students' morals can be expected to be embedded both from elementary school age to college so as to provide positive implications to Religion, Nation and State.
IMPLEMENTATION OF THE MOZAIK METHOD TO RECOGNIZE VOCAL LETTERS IN LITTLE DISABILITY CHILDREN
Authors: Zulfa Milatul
Published: November 2021

This study aims to determine the implementation process or the application of the mosaic method in introducing vowels for mild retarded children who are in grade 1 at Giwangan Elementary School in Yogyakarta. In addition, this study also aims to determine the changes that occur in mild retarded students after using the mosaic method in learning Indonesian, specifically to introduce vowels. This research uses qualitative methods with descriptive qualitative research. The subjects in this study were grade 1 students with intellectual disabilities who had the initials X at Giwangan Elementary School in Yogyakarta. The object of this research is the application of the mosaic method as a solution to introduce vowels in mildly retarded children. Data collection techniques such as observation, interviews, documentation, and field notes. The results of this study indicate that by using the mosaic method in learning the introduction of vowels in mild retarded children is actually feeling very enthusiastic and have a spirit of learning rather than by using methods that have been previously applied. In addition, with mild mental retardation X, was very happy and painstaking with little by little sticking pieces of paper that were pasted and arranged to be a letter in question.
Del mito de las economías capitalistas a la realidad de las economías mixtas
Authors: Tejedor Estupiñán Joan Miguel
Published: November 2021

El periodo de transición del feudalismo al capitalismo también está reflejado en el paso de la etapa preindustrial a la industrial. Durante varios siglos el feudalismo y el capitalismo convivieron, mientras que el capitalismo se expandía por Europa y el mundo fundamentado en las principales corrientes proteccionistas y librecambistas del siglo XVIII y XIX. El mercantilismo fue una de las primeras escuelas económicas que se impulsaron desde finales del siglo XV y hasta el siglo XVIII desde las nuevas monarquías de Inglaterra, Francia, España, Portugal y Alemania, la cual se conformó por una serie de políticas para promover la protección y expansión del comercio exterior europeo.
Alcance de los créditos a tasa subsidiada para mipymes Argentinas
Authors: Corzo Lilia , Guercio M. Belén , Vigier Hernán Pedro
Published: November 2021

El objetivo de este artículo es analizar el alcance de los créditos bancarios a tasa subsidiada para mipymes. Se estima un modelo Logit para examinar los determinantes de la demanda efectiva y potencial para empresas argentinas en 2017. Los principales resultados muestran que las empresas con necesidades insatisfechas de crédito bancario tradicional presentan una menor demanda efectiva y potencial. Además,se observa una relación positiva entre el tamaño de la empresa y la demanda efectiva. La demanda potencial, por su parte, es explicada por la forma jurídica, el acceso al crédito comercial, la educación del gerente y haber experimentado una pérdida de inversión por falta de crédito. Este estudio genera bases para rediseñar y mejorar el alcance de los programas de financiamiento para mipymes.
Revisiting inflation and growth nexus: an asymmetric cointegration based on Non-linear ARDL approach in case of Bangladesh
Authors: Ahmed Zobayer
Published: November 2021

Sustainable high economic growth is the major objective of a country. Whereas inflation is one of the critical factors that affect economic development. Growth-inflation nexus is one of the most controversial topics in this present world. This study re-investigates the link between inflation and the economic development of Bangladesh by employing a non-linear autoregressive distributed lagged (NARDL) approach. For this study, we use annual time series data set on the growth rate of per capita gross domestic product, and the inflation rate for the time range from 1986 to 2017. The asymmetric cointegration result based on the NARDL approach shows the confirmation of long-run integration between the GDP growth rate and inflation rate (CPI). The study finds a positive and robust nexus between growth rate and inflation rate. The relationship exists both in the long-run as well as in the short-run. The results also have statistically significant. This study further explores that there is an asymmetric relationship between the rate of inflation and the rate of economic growth. The nonlinear ARDL approach shows that the GDP growth rate responds more with an upward change in inflation than that of a downward change.

Furthermore, in the short-run, the positive change in inflations has a significant and positive influence on the growth rate. Still, the influence of an adverse change in inflations has statistically insignificant. Both the policymakers of Bangladesh (Bangladesh Bank) and development partners working in the country can be benefited from these results in the context of policy implementation. This study recommends that to boosting up the economic growth in the context of Bangladesh, the inflation rate can be treated as a significant determination.
Kosmova kreativní nápověda?
Authors: NOVOTNÝ Jiří
Published: November 2021

První kniha Kosmovy Kroniky Čechů vykazuje výraznou anomálii. Kosmas porušil kontinuální chronologickou kompozici první knihy a při líčení počátků christianizace Čech ve 2. polovině 9. století vložil mezi data knížete Bořivoje I. a jeho ženy Ludmily rozsáhlou epizodu o smrti luckého knížete Vlastislava. Je možné, že nejstarší český kronikář nepřímo – ale vědomě – upozornil na pravý původ kněžny a pozdější světice Ludmily, o kterém se dodnes vedou spory.
The Exemplarity of Particulars: Arendt on Validity
Authors: Blumenthal-Barby Martin
Published: November 2021

When Hannah Arendt delivered her Lectures on Kant’s Political Philosophy at the New School for Social Research in 1970, she held a seminar on Kant’s Critique of Judgment to explore aspects of her lecture course in greater detail. This essay probes Arendt’s seminar notes with an eye to the concept of ‘exemplary validity,’ which is at the core of her theory of judgment. Notably, her analysis repeatedly draws on the force of examples, that is, the force of ‘exemplary validity.’ Her theorization of judgment, itself inevitably subject to her own judgment, can be understood as an enactment of and commentary on the very matter she discusses. It is not by chance but rather symptomatic that her argumentation is permeated by strategically placed examples that seek to persuade us by dint of their exemplary validity.
Verfahren zur Synchronisation betriebsparalleler Simulationen durch Online-Parameterschätzung
Authors: Zipper Holger
Published: November 2021

Die Bedeutung von Simulation im industriellen Umfeld nimmt stetig zu. Durch Entwicklungen im Rahmen des digitalen Zwillings rückt zunehmend die betriebsparallele Simulation in den Fokus. Damit lassen sich Szenarien wie die Online-Optimierung von Durchlaufzeiten oder die Fehlerdetektion realisieren. Eine Herausforderung der betriebsparallelen Simulation ist jedoch der Umgang mit Abweichungen der Simulationsmodelle von der industriellen Anlage, welche nicht nur Aufgrund von vereinfachenden Annahmen während der Modellierung auftreten, sondern auch durch Alterung oder Umbau der industriellen Anlage entstehen. Die Arbeit beschäftigt sich daher mit der Entwicklung der Zustandssynchronisierung, welche eine betriebsparallele Simulation an eine industrielle Anlage kontinuierlich angleicht.
Open research issues on management of industrial wireless sensor systems applied to process automation
Authors: Feldman Max , Cainelli Gustavo P. , Künzel Gustavo , Müller Ivan , Pereira Carlos E.
Published: November 2021

Industrial wireless networks are a key technology for the implementation of the Industry 4.0 concepts. Due to its advantages in relation to wired networks, such as flexibility and low cost of installation, these networks are gaining momentum in the recent years. Wireless networks are becoming even more attractive for industrial applications and consequently an increase is expected in the number of wireless devices connected to industrial applications. As a result, efficient network management becomes even more relevant, and consequently new techniques are necessary to cope with new demands. Network management tasks, such as routing, scheduling, coexistence awareness, and mobility, have been in focus of scientific community. However, several important research questions remain open. This paper presents recent works on industrial wireless networks management techniques in addition with the presentation of open research issues.
An iterative approximation of common solutions of split generalized vector mixed equilibrium problem and some certain optimization problems
Authors: Mewomo Oluwatosin T. , Oyewole Olawale K.
Published: November 2021

In this paper, we study the problem of finding a common solution of split generalized vector mixed equlibrium problem (SGVMEP), fixed point problem (FPP) and variational inequality problem (VIP). We propose an inertial-type iterative algorithm, which uses a projection onto a feasible set and a linesearch, which can be easily calculated. We prove a strong convergence of the sequence generated by the proposed algorithm to a common solution of SGVMEP, fixed point of a quasi-

ϕ

\phi

-nonexpansive mapping and VIP for a general class of monotone mapping in 2-uniformly convex and uniformly smooth Banach space

E

1

{E}_{1}

and a smooth, strictly convex and reflexive Banach space

E

2

{E}_{2}

. Some numerical examples are presented to illustrate the performance of our method. Our result improves some existing results in the literature.
Stability analysis of fractional order SEIR model for malaria disease in Khyber Pakhtunkhwa
Authors: Badshah Noor , Akbar Haji
Published: November 2021

We discussed stability analysis of susceptible-exposed-infectious-removed (SEIR) model for malaria disease through fractional order and check that malaria is epidemic or endemic in Khyber Pakhtunkhwa (Pakistan). We show that the model has two types of equilibrium points and check their stability through Routh-Hurwitz criterion. We find basic reproductive number using next-generation method. Finally, numerical simulations are also presented.
Critical Galton–Watson Processes with Overlapping Generations
Authors: Sagitov Serik
Published: November 2021

A properly scaled critical Galton–Watson process converges to a continuous state critical branching processξ⁢(⋅)\xi(\,{\cdot}\,)as the number of initial individuals tends to infinity. We extend this classical result by allowing for overlapping generations and considering a wide class of population counts. The main result of the paper establishes a convergence of the finite-dimensional distributions for a scaled vector of multiple population counts. The set of the limiting distributions is conveniently represented in terms of integrals (∫0yξ⁢(y-u)⁢duγ\int_{0}^{y}\xi(y-u)\,du^{\gamma},y≥0y\geq 0) with a pertinentγ≥0\gamma\geq 0.
Positive periodic solutions to the forced non-autonomous Duffing equations
Authors: Šremr Jiří
Published: November 2021

We study the existence and multiplicity of positive solutions to the periodic problem for a forced non-autonomous Duffing equation

u
′′

=

p
⁢

(
t
)

⁢
u

-

h
⁢

(
t
)

⁢

|
u
|

λ

⁢

sgn
⁡
u

+

f
⁢

(
t
)

;

u
⁢

(
0
)

=

u
⁢

(
ω
)

,

u
′

⁢

(
0
)

=

u
′

⁢

(
ω
)

,

u^{\prime\prime}=p(t)u-h(t)\lvert u\rvert^{\lambda}\operatorname{sgn}u+f(t);\quad u(0)=u(\omega),\ u^{\prime}(0)=u^{\prime}(\omega),

where

p
,
h
,
f

∈

L
⁢

(

[
0
,
ω
]

)

p,h,f\in L([0,\omega])

and

λ
>
1

\lambda>1

.
The obtained results are compared with the results known for the equations with constant coefficients.
Adaptive space–time finite element methods for parabolic optimal control problems
Authors: Langer Ulrich , Schafelner Andreas
Published: November 2021

We present, analyze, and test locally stabilized space–time finite element methods on fully unstructured simplicial space–time meshes for the numerical solution of space–time tracking parabolic optimal control problems with the standardL2-regularization.We derive a priori discretization error estimates in terms of the local mesh-sizes for shape-regular meshes. The adaptive version is driven by local residual error indicators, or, alternatively, by local error indicators derived from a new functional a posteriori error estimator. The latter provides a guaranteed upper bound of the error, but is more costly than the residual error indicators. We perform numerical tests for benchmark examples having different features. In particular, we consider a discontinuous target in form of a first expanding and then contracting ball in 3d that is fixed in the 4d space– time cylinder.
Magnetized couple stress fluid flow past a vertical cylinder under thermal radiation and viscous dissipation effects
Authors: Palaiah Suresha Suraiah , Basha Hussain , Reddy Gudala Janardhana
Published: November 2021

Contemporary investigation studies the silent features of the dissipative free convection couple stress fluid flow over a cylinder under the action of magnetic field, thermal radiation and porous medium with chemical reaction effect. Present two-dimensional viscous incompressible physical model is designed based on the considered flow geometry. Present physical problem gives the highly complicated nonlinear coupled partial differential equations (PDE's) which are not amenable to any of the known techniques. Thus, unconditionally stable, most accurate and speed converging with flexible finite difference implicit technique is utilized to simplify the dimensionless flow field equations. It is apparent from the current results that; the velocity profiles are diminished with enhancing values of magnetic field. Temperature profile increases with enhancing values of thermal radiation parameter. Velocity contours deviates away from the wall with enhancing magnetic parameter. Also, the effects of magnetic field, porous medium, thermal radiation, chemical reaction, buoyancy ratio parameter and Eckert number on couple stress flow velocity, temperature, and concentration profiles are studied. However, the present study has good number of applications in the various fields of engineering such as; polymer processing, solidification of liquid crystals, colloidal solutions, synovial joints, geophysics, chemical engineering, astrophysics and nuclear reactors etc. Finally, the current solutions are validated with the available results in the literature review and found to be in good agreement.
Two-scale haemodynamic modelling for patients with Fontan circulation
Authors: Dobroserdova Tatiana K. , Vassilevski Yuri V. , Simakov Sergey S. , Gamilov Timur M. , Svobodov Andrey A. , Yurpolskaya Lyudmila A.
Published: November 2021

Palliation of congenital single ventricle heart defects suggests multi-stage surgical interventions that divert blood flow from the inferior and superior vena cava directly to the right and left pulmonary arteries, skipping the right ventricle. Such system with cavopulmonary anastomoses and single left ventricle is called Fontan circulation, and the region of reconnection is called the total cavopulmonary connection (TCPC). Computational blood flow models allow clinicians to predict the results of the Fontan operation, to choose an optimal configuration of TCPC and thus to reduce negative postoperative consequences. We propose a two-scale (1D3D) haemodynamic model of systemic circulation for a patient who has underwent Fontan surgical operation. We use CT and 4D flow MRI data to personalize the model. The model is tuned to patient’s data and is able to represent measured time-averaged flow rates at the inlets and outlets of TCPC, as well as pressure in TCPC for the patient in horizontal position.We demonstrate that changing to quiescent standing position leads to other patterns of blood flow in regional (TCPC) and global haemodynamics. This confirms clinical data on exercise intolerance of Fontan patients.
Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure
Authors: Harris Kelly C. , Ahlstrom Jayne B. , Dias James W. , Kerouac Lilyana B. , McClaskey Carolyn M. , Dubno Judy R. , Eckert Mark. A.
Published: November 2021

A common complaint of older adults is difficulty understanding speech, particularly in challenging listening conditions. Accumulating evidence suggests that these difficulties may reflect a loss and/or dysfunction of auditory nerve (AN) fibers. We used a novel approach to study age-related changes in AN structure and several measures of AN function, including neural synchrony, in 58 older adults and 42 younger adults. AN activity was measured in response to an auditory click (compound action potential; CAP), presented at stimulus levels ranging from 70 to 110 dB pSPL. Poorer AN function was observed for older than younger adults across CAP measures at higher but not lower stimulus levels. Associations across metrics and stimulus levels were consistent with age-related AN disengagement and AN dyssynchrony. High-resolution T2-weighted structural imaging revealed age-related differences in the density of cranial nerve VIII, with lower density in older adults with poorer neural synchrony. Individual differences in neural synchrony were the strongest predictor of speech recognition, such that poorer synchrony predicted poorer recognition of time-compressed speech and poorer speech recognition in noise for both younger and older adults. These results have broad clinical implications and are consistent with an interpretation that age-related atrophy at the level of the AN contributes to poorer neural synchrony and may explain some of the perceptual difficulties of older adults.

SIGNIFICANCE STATEMENTDifferences in auditory nerve (AN) pathophysiology may contribute to the large variations in hearing and communication abilities of older adults. However, current diagnostics focus largely on the increase in detection thresholds, which is likely because of the absence of indirect measures of AN function in standard clinical test batteries. Using novel metrics of AN function, combined with estimates of AN structure and auditory function, we identified age-related differences across measures that we interpret to represent age-related reductions in AN engagement and poorer neural synchrony. Structure-function associations are consistent with an explanation of AN deficits that arise from age-related atrophy of the AN. Associations between neural synchrony and speech recognition suggest that individual and age-related deficits in neural synchrony contribute to speech recognition deficits.
Spatial and seasonal distribution of dissolved and particulate bioactive metals in Antarctic sea ice
Authors: Duprat Luis , Townsend Ashley T. , van der Merwe Pier , Meiners Klaus M. , Lannuzel Delphine
Published: November 2021

Iron (Fe) has been shown to limit growth of marine phytoplankton in the Southern Ocean, regulating phytoplankton productivity and species composition, yet does not seem to limit primary productivity in Antarctic sea ice. Little is known, however, about the potential impact of other metals in controlling sea-ice algae growth. Here, we report on the distribution of dissolved and particulate cadmium (Cd), cobalt (Co), copper (Cu), manganese (Mn), nickel (Ni), and zinc (Zn) concentrations in sea-ice cores collected during 3 Antarctic expeditions off East Antarctica spanning the winter, spring, and summer seasons. Bulk sea ice was generally enriched in particulate metals but dissolved concentrations were similar to the underlying seawater. These results point toward an environment controlled by a subtle balance between thermodynamic and biological processes, where metal availability does not appear to limit sea-ice algal growth. Yet the high concentrations of dissolved Cu and Zn found in our sea-ice samples raise concern about their potential toxicity if unchelated by organic ligands. Finally, the particulate metal-to-phosphorus (P) ratios of Cu, Mn, Ni, and Zn calculated from our pack ice samples are higher than values previously reported for pelagic marine particles. However, these values were all consistently lower than the sea-ice Fe:P ratios calculated from the available literature, indicating a large accumulation of Fe relative to other metals in sea ice. We report for the first time a P-normalized sea-ice particulate metal abundance ranking of Fe >> Zn ≈ Ni ≈ Cu ≈ Mn > Co ≈ Cd. We encourage future sea-ice work to assess cellular metal quotas through existing and new approaches. Such work, together with a better understanding of the nature of ligand complexation to different metals in the sea-ice environment, would improve the evaluation of metal bioavailability, limitation, and potential toxicity to sea-ice algae.
The Research of Blast Resistant of Reinforcement Concrete Beams in Concrete Structures at Off-site Oil and Gas Plant
Authors: Aljasmi Salah , Ariffin Nur Farhayu , Abu Seman Mazlan
Published: November 2021

In the recent decades, blasts and gas explosions at the off-site of oil and gas plants have increased leading to destruction of important concrete structures, essential equipment and loss of human life. In response, structural engineers have come up with different ways of reinforcing beams of concrete structures using fiber reinforced polymers composite materials to produce blast resistant structures to minimize the impact of the blast loads, due to their unique and individual characteristics like high flexural and shear strength. This paper seeks to research the dynamic behavior, response and performance of reinforce concrete beams strengthened with Carbon Fiber Reinforced Polymer composites when subjected to blast loading. The study aims at proposing a design model of strengthening reinforce concrete beams with Carbon Fiber Reinforced Polymer in supporting concrete structures at off-site oil and gas plants against hydrocarbon explosions.  Carbon Fiber Reinforced Polymer composites exhibit higher modulus of elasticity, higher energy absorption capacity, resistant to all forms of alkali and higher tensile strength compared to all other fiber reinforced polymers reinforcements and therefore the need to assess its capacity in protecting concrete structures at oil and gas plants against dynamic loads. The research will be carried out through numerical analysis using the finite element analysis computer program, ANSYS.
Recibir y donar sangre: ¿entre la solidaridad, la generación de lazos sociales y la cosificación? Las paradojas de la transfusión en un contexto clínico pluricultural
Authors: Gómez-Cardona Liliana
Published: November 2021

En este artículo abordo la transfusión de sangre desde el punto de vista de algunas familias de diferentes orígenes sociales, nacionales y económicos que residen en Montreal (Canadá), cuyos hijos e hijas son transfundidos. Mi objetivo es examinar la experiencia de recibir una transfusión y las opiniones frente al sistema de donación de sangre. Me baso en una metodología cualitativa a partir de la observación participante, entrevistas semidirigidas y el análisis temático. Exploro las perspectivas de las personas desde la antropología médica crítica, y el debate sobre el alcance social y cosificante de los sistemas de tratamiento de los tejidos orgánicos. Con base en este trabajo, concluyo que las familias perciben el sistema de recolección de sangre de manera ambivalente y tienen diferentes reacciones frente al anonimato, la restitución de la sangre y los lazos que se generan entre donantes y receptores.
Benshoanon: el proceso curativo de la medicina tradicional del pueblo indígena shipibo-konibo”.
Authors: Favaron Pedro , Bensho Chonon
Published: November 2021

El presente artículo ha sido escrito por una pareja de esposos comuneros empadronados de la comunidad nativa de Santa Clara de Yarinacocha, del pueblo shipibokonibo, uno de los más numerosos de la Amazonía peruana, reconocido por la sabiduría de sus antiguos médicos meraya. El trabajo propone una explicación del proceso curativo de la medicina tradicional desde las propias racionalidades indígenas, sin imponer categorías eurocéntricas, y a partir de un modo de escritura académica intercultural que permite a los saberes indígenas expresarse sin perder su temperamento poético y narrativo. Plantea, asimismo, un diálogo intercultural con la medicina académica y con la sociedad moderna, para tratar de ensanchar la visión sobre el ser humano y la salud.
Los otros xantolos, miradas de inclusión y migración alrededor de un ritual en la Huasteca potosina, México
Authors: Mirabal Arturo
Published: November 2021

Este trabajo etnográfico examina los aspectos rituales y el impacto de la migración en una de las celebraciones de mayor relevancia en México, el Día de Muertos, en su versión nahua-huasteca, el Xantolo, en el estado mexicano de San Luis Potosí. Dicha fiesta refleja algunas transformaciones en la vida local, tanto en las comunidades nahua como en las cabeceras municipales. Examino la manera en que la migración de los y las nahuas a la ciudad industrial norteña de Monterrey y su participación en la celebración, han incidido en la mayor representación y visibilidad de las mujeres mestizas e indígenas y de las personas no heterosexuales en el Xantolo.
Personagens subalternas em Milton Hatoum
Authors: Nogueira-Pretti Luciana Persice
Published: November 2021

Inserindo a abordagem de algumas personagens subalternas dos três primeiros romances de Milton Hatoum no quadro dos Estudos da Subalternidade, particularmente segundo aportes do ensaio Pode o subalterno falar?, da crítica e teórica indiana Gayatry Spivak, é possível rastrear elementos de continuidade na caracterização dessas personagens: Anastácia Socorro (Relato de um certo Oriente, 1989), Domingas (Dois irmãos, 2000) e Naiá (Cinzas do Norte, 2005) são empregadas agregadas e subalternas às famílias às quais servem. Podem ser destacados, porém, traços distintivos e diferenciados entre elas, que dão conta da heterogeneidade desse grupo (que não é típico ou “monolítico”, novamente em referência à análise de Spivak). De uma a outra, na busca de uma individuação dessas personagens na obra do autor, procedemos ao que o filósofo francês Pierre Macherey (citado por Spivak em seu ensaio) preconizou como método, mas que desenvolveremos como dinâmica de investigação: “medir silêncios”, observar o que essas mulheres calam ou dizem, tentando dar-lhes voz, ouvir suas reticências e valorizar sua presença no texto.
Subalternidade racial em Torto arado
Authors: Oliveira Thallys , Ferreira Ana Emília
Published: November 2021

Neste trabalho, analisamos o modo como acontece, na obra Torto arado (2019), de Itamar Vieira Junior, o processo de evolução de consciência relacionada à condição de subalternidade a nível racial. Tal processo pode ser apreendido a partir das ações das personagens, que passam a assumir uma postura ativa frente à tradicional estrutura de exploração a que estão submetidas. A partir dos episódios apresentados pelas narradoras do romance, três mulheres negras que contam a própria história e a do grupo que integram, identificamos, descrevemos e interpretamos eventos que, em um primeiro momento, sinalizam um estágio de submissão das personagens, e que, em um segundo momento, sugerem um alcance de consciência a respeito de sua condição subalterna. A fim de embasar nossas proposições analíticas, apoiamo-nos nas considerações de Gayatri Spivak (2010), sobre o conceito de subalternidade; de Proença Filho (2004), a respeito da trajetória do negro na literatura brasileira; de Dalcastagnè (2008), acerca das relações raciais na literatura brasileira contemporânea; e de Albuquerque e Fraga Filho (2006), como referencial historiográfico.
O desterro de ser daqui
Authors: Vivian Ilse M. R.
Published: November 2021

A narrativa literária brasileira tem apresentado, especialmente nas últimas três décadas, discursos que dialogam com noções do amplo movimento de epistemologias decoloniais da América Latina, principalmente no que tange à (re/des)construção de estéticas orientadas pela hegemonia cultural europeia e à subversão da noção de experiência concebida pela Modernidade. Esses pressupostos guiam o presente estudo, que se dedica à leitura dos romances Becos da memória (2006), de Conceição Evaristo, e Com armas sonolentas (2018), de Carola Saavedra. Da perspectiva das protagonistas, mulheres que se enunciam a partir das subjetividades fronteiriças e se compõem pela vivência e saberes locais, emanam dessas narrativas vozes que, impregnadas pela experiência da violência e do exílio, esse entendido conforme as ressignificações de Said (2003), reinventam as próprias identidades com base na noção de coletividade, confrontando, por essa via, as estruturas hegemônicas e centralizadoras das políticas globalizantes. Além de constituírem severas críticas à retórica excludente da Modernidade, quando problematizam a relação eu/outro e o lugar de fala reservado ao homem branco, esses romances evocam as origens e a ancestralidade, questionando a cadeia de processos que estabelece os lugares de poder cultural e suas forjadas hierarquias.
Decolonizando a violência contra as mulheres subalternas em Elvira Vigna
Authors: Santos Gardênia Dias , Gomes Carlos Magno
Published: November 2021

Este artigo busca identificar como a violência contra as personagens femininas subalternas está retratada na obra Como se estivéssemos em palimpsesto de putas (2016), de Elvira Vigna. Partimos de uma abordagem feminista decolonial com o intuito de identificar as estratégias narrativas usadas pela narradora para explicitar as opressões aniquiladoras do protagonista, João, que impõe sua masculinidade por meio de sexo pago. Como subsídios teóricos, traremos os estudos de Lugones (2019) sobre a decolonização do gênero, de Segato (2003) acerca da violência estrutural que silencia as mulheres, e de Hutcheon (1993) sobre a paródia como uma estratégia política de revisão feminista.
O Caso Meursault, de Kamel Daoud
Authors: Oliveira Cleide Silva de , Lopes Sebastião Alves Teixeira
Published: November 2021

Este artigo propõe-se à análise do romance O caso Meursault, de Kamel Daoud enquanto apropriação pós-colonial de O estrangeiro, de Albert Camus. O objetivo é investigar como Daoud reconstrói ficcionalmente a identidade árabe invisibilizada na escrita de O estrangeiro. O caso Meursault ressignifica o cânone literário através da reinvindicação da identidade do árabe assassinado. A voz enquanto instância de humanização é negada ao homem assassinado no texto camusiano, enquanto que, Daoud ocupa-se de uma enunciação pós-colonial para conceder-lhe voz, família, história e nome: Moussa. O aporte teórico baseia-se nas noções apresentadas por Homi Bhabha (2014), Edward W. Said (2011), Frantz Fanon (2008), Gayatri Spivak (2010), Daniela Burksdorf (2015) e Ankhi Mukherjee (2014). Conclui-se que a apropriação pós-colonial de Daoud revela uma ruptura com a invisibilidade da personagem árabe de Camus, ao mesmo tempo em que revisita o passado recente de dominação e exploração colonial francesa na Argélia.
Personagens subalternas nas literaturas de língua portuguesa
Authors: Amodeo Maria Tereza , Amorim Sílvia , Silva Ívens Matozo
Published: November 2021

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O conto autoficcional de Veronica Stigger
Authors: Ferraz Bruna
Published: November 2021

Este texto visa a refletir sobre o conto autoficcional de Veronica Stigger, evidenciando como a autora supera esse conceito ao constatar o seu desgaste na literatura contemporânea. Para isso, analisaremos três contos de Stigger: “O livro”, publicado em Sombrio Ermo Turvo, “Imagem verdadeira” e “200 m2”, publicados em Os anões, textos que se apresentam como paródias da autoficção e que ressaltam como a escritora gaúcha, ao transmutar-se em personagem, distorce sua própria imagem, num processo especular de seus textos e da própria autoria. Ao considerarmos as características do conto contemporâneo e as especificidades do conto de Stigger, procuramos evidenciar, tomando como aporte teórico, sobretudo, os estudos sobre autoficção de Vicent Colonna e os ensaios sobre os espelhos de Umberto Eco, como Stigger forja vidas inusitadas para si para mostrar que tudo é ficção.
Helena Parente Cunha e Lucilene Machado:
Authors: Oliveira Marta Francisco de , Lima Marcia Gomes de
Published: November 2021

Através da aproximação de leituras de contos de duas escritoras brasileiras, Helena Parente Cunha e Lucilene Machado Garcia Arf, o presente artigo versa acerca do que consideramos narrativas do corpo feminino, ampliando a compreensão de ‘corpo’ para sua multiplicidade de sentidos e formas de constituição, enquanto discurso e objeto atravessado pela discursividade, pela linguagem, literal e metaforicamente. A proposta de leitura dos contos “O pai” e “Novembro em poucas cores” traça um percurso simbólico entre tempo e narrativas, com foco no processo da escrita e nos sentidos do texto e da autoria. Ao longo das considerações, a reflexão também abarca o processo de identificação na narrativa em construção, e ressalta a força e a potência das escritoras contistas brasileiras contemporâneas, na figura dessas duas autoras e seus textos.
“Uma trilha para libertação de outros”
Authors: Rocha Vanessa Massoni da , Silva Luciely da
Published: November 2021

Este artigo se propõe a cartografar a ideia de (não-) pertencimento de personagens negros retratados no livro de contos Olhos d’água (2014), da escritora mineira Conceição Evaristo. Em nossas análises, privilegiaremos três contos da obra, “Duzu-Querença”, “O cooper de Cida” e “Ei, Ardoca”, nos quais se descortinam os matizes da obra, tais como o racismo, o silenciamento, o sofrimento, as dores, o anonimato, a violência e o suicídio. Intenciona-se fomentar o debate a respeito de como os caminhos são negados (ou, ao menos, dificultados) para sujeitos negros no seio da sociedade e, por outro lado, busca-se ressaltar o viés literário como espaço de visibilidade para seres anônimos reiteradamente cantonados.  De maneira mais detalhada, pretende-se observar aspectos da tessitura textual de Conceição Evaristo, notadamente no que diz respeito à constituição das vozes narrativas. Para isso, adotamos a perspectiva decolonial (Almeida, Césaire, Kilomba, Salgueiro), ressaltamos as reflexões em torno do feminismo negro (Akotirene, Kilomba, Ribeiro), da necropolítica (Mbembe), da presença dos negros na literatura feminina contemporânea (Dalcastagnè), além de percorrer obras literárias e entrevistas de Evaristo, além de críticas teóricas sobre sua obra.
USE OF DEEP OSCILLATION - THERAPY IN REHABILITATION PROGRAM FOR PATIENT AFTER DISTAL RADIUS FRACTURE WITH A COMPLEX REGIONAL PAIN SYNDROME: A CASE REPORT
Authors: Мratskova G.
Published: November 2021

THE PURPOSE is to present a clinical case of a patient with a fracture of the distal radius and complex regional pain syndrome I, in which complex rehabilitation was applied, including Deep Oscillation, cryotherapy and therapeutic exercises. MATERIALS AND METHODS: The rehabilitation program was conducted to a 62-year-old woman, four months after the injury. The intervention includes Deep Oscillation in biphasic mode (up to 7μA) and therapeutic exercises 10 procedures. The clinical symptoms were assessed before and after therapy and after 1-st and 3-rd months after therapy. RESULTS: Reduction in pain (VAS) after therapy from “very strong” (75mm) before therapy, to “mild” at 3 months (12mm) was observed. Reduction of wrist swelling and muscle weakness as assessed by manual muscle testing was observed. The range of movement in the sagittal plane from 25º-0-35º to 70º-0º-85º and the frontal plane from 5º-0-15º to 20º-0º-35º was increase. Improved performance of activities of daily living was observed. No adverse events with Deep Oscillation therapy were observed. CONCLUSION: Deep Oscillation and therapeutic exercises effectively reduce the clinical symptoms of regional pain syndrome. To establish the therapeutic efficacy of Deep Oscillation treatment after a fracture of the distal radius with complex regional pain syndrome, randomized studies involving a larger number of patients are required.