bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure and function of fermentation-derived bovine lactoferrin produced from Komagataella phaffii
Authors: Skoog Emma C. , Castagna Vanessa Feher , Omer Shafraz , Madigan Julianna , Flagg Victoria , Burrick Kristen , Jiang Rulan , Du Xiaogu , Lönnerdal Bo , Schnitzler Aletta
Published: September 2024

Bovine lactoferrin (bLf) confers significant functional benefits for human health, but low concentrations in milk and high cost of commercial production limit availability and thus product application. Precision fermentation offers a solution to increase availability of biosimilar recombinant bLf (rbLf) thereby opening new opportunities for this high-value ingredient. To comply with regulatory requirements, we aimed to establish that rbLf from Komagataella phaffii is substantially similar to native bLf in structure and key functions. Intact mass analysis showed a molecular weight of 84 kDa for rbLf, comparable to 82–83 kDa of bLf. LC-MS N-linked glycan profiling revealed predominantly high-mannose-based glycans on rbLf, similar to ∼50% of bLf glycans. The isoelectric point and core amino acid sequence of rbLf and bLf are identical. rbLf retains the functional ability to bind and release iron, bind to intestinal Lf receptors, increase epithelial cell growth (>120% of control, P < 0.0001), reduce enteropathogenic Escherichia coli growth (>50% reduction, P < 0.0001), bind lipopolysaccharide (LPS) (+4-fold, P < 0.001), and antagonize LPS-induced toll-like receptor 4 activity (>40% reduction, P < 0.0001). These results demonstrate similarity of rbLf in structure and function to native bLf, supporting the effective application for expanded market opportunities for infant and adult health.
ANALYSIS ON MULTIPLICATIVELY (P,m)-SUPERQUADRATIC FUNCTIONS AND RELATED FRACTIONAL INEQUALITIES WITH APPLICATIONS
Authors: KHAN DAWOOD , BUTT SAAD IHSAN , SEOL YOUNGSOO
Published: September 2024

In this work, we, for the first time, establish a class of multiplicatively [Formula: see text]-superquadratic function and look into its various features. In the light of these features, we come up with the several integer order integral inequalities in the frame of multiplicative calculus. Moreover, we develop the fractional version of Hermite–Hadamard’s type inequalities involving midpoints and end points for multiplicatively [Formula: see text]-superquadratic function with respect to multiplicatively [Formula: see text]-Riemann–Liouville fractional integrals. By choosing different values for the parameters of such integral operators, we acquire a simple version of integral inequalities of Hermite–Hadamard’s type as well as its fractional form via multiplicatively Riemann–Liouville fractional integrals for multiplicatively [Formula: see text]-superquadratic function. The findings are confirmed by graphical illustration by taking appropriate examples into account. The study is further enhanced by the addition of applications of special means and first-type modified Bessel functions. The new results clearly provide extensions and improvements of the work available in the literature.
A Multifocal Graph-Based Neural Network Scheme for Topic Event Extraction
Authors: Wan Qizhi , Wan Changxuan , Xiao Keli , Hu Rong , Liu Dexi , Liao Guoqiong , Liu Xiping , Shuai Yuxin
Published: September 2024

Event extraction is a long-standing and challenging task in natural language processing, and existing studies mainly focus on extracting events within sentences. However, a significant problem that has not been carefully investigated is whether an “event topic” can be identified to represent the main aspects of extracted events. This article formulates the “topic event” extraction problem, aiming to identify a representative event from extracted ones. Specifically, after defining the topic event, we develop a multifocal graph-based framework to handle the extraction task. To enrich the associations of events and their tokens, we construct four event graphs, including the event subgraph and three event-associated graphs (i.e., event dependency parsing graph, event organization graph, and event share token graph), that reflect the internal and external structures of events, respectively. Subsequently, we design a multi-attention event-graph neural network to capture these event graph structures and improve event subgraph embedding. Finally, the output embeddings in the last layer of each channel are concatenated and fed into a fully connected network for topic event recognition. Extensive experiments validate the effectiveness of our method, and the results confirm its superiority over state-of-the-art baselines. In-depth analyses explore the essential factors (e.g., graph structures, attentions, feature generation method, etc.) determining the extraction performance.
TTPXHunter: Actionable Threat Intelligence Extraction as TTPs from Finished Cyber Threat Reports
Authors: Rani Nanda , Saha Bikash , Maurya Vikas , Shukla Sandeep Kumar
Published: September 2024

Understanding the modus operandi of adversaries aids organizations to employ efficient defensive strategies and share intelligence in the community. This knowledge is often present in unstructured natural language text within threat analysis reports. A translation tool is needed to interpret the modus operandi explained in the sentences of the threat report and convert it into a structured format. This research introduces a methodology named TTPXHunter for automated extraction of threat intelligence in terms of Tactics, Techniques, and Procedures (TTPs) from finished cyber threat reports. It leverages cyber domain-specific state-of-the-art natural language model to augment sentences for minority class TTPs and refine pinpointing the TTPs in threat analysis reports significantly. We create two datasets: an augmented sentence-TTP dataset of

\(39,296\)

sentence samples and a

\(149\)

real-world cyber threat intelligence report-to-TTP dataset. Further, we evaluate TTPXHunter on the augmented sentence and report datasets. The TTPXHunter achieves the highest performance of

\(92.42\%\)

f1-score on the augmented dataset, and it also outperforms existing state-of-the-art TTP extraction method by achieving an f1-score of

\(97.09\%\)

when evaluated over the report dataset. TTPXHunter significantly improves cybersecurity threat intelligence by offering quick, actionable insights into attacker behaviors. This advancement automates threat intelligence analysis and provides a crucial tool for cybersecurity professionals to combat cyber threats.
Interpersonal Relationships in Organizations: Building Better Pipes and Looking Through Prisms
Authors: Rockmann Kevin W. , Bartel Caroline A.
Published: September 2024

In this review, we attempt to make sense of the broad, complex, fascinating yet incomplete literatures that implicate interpersonal relationships in organizations by focusing on how relationships are treated and what relationships do for organizations and the people therein. We leverage the existing literature to push the study of interpersonal relationships in organizations in three ways. First, we conceptualize relationships in ways that are deeper than are typically studied, in terms of the nature of interpersonal bonds, the trajectory of relationships, and how relationships are measured. Second, we build on multilevel research that demonstrates how (top-down) organization-level processes and relational systems impact dyadic relationships and associated outcomes, and how (bottom-up) those same relationships implicate organizational processes and outcomes. Third, we describe the potential of viewing relationships not just as pipes for the direct transmission of knowledge and socioemotional support but as prisms for studying indirect processes of attention and interpretation.
Investigation the Structure and Linear/Nonlinear Spectroscopic Performance of Fe:Co3O4/TiO2 Nanostructured Heterojunctions
Authors: Badawi Ali , Alharthi Sami S. , A. Alotaibi Abdullah , Althobaiti M. G.
Published: September 2024

The structure and linear/nonlinear spectroscopic performance of Fe:Co3O4/TiO2 (FCTO) nanostructured heterojunctions (HJs) were investigated. Pure TiO2 nanostructures and FCTO nanostructured HJs were synthesized by spray pyrolysis technique. The surfaces morphology of the samples was examined utilizing a scanning electron microscope. Energy-dispersive X-ray measurements were performed to confirm the content of the prepared FCTO HJs. The structures’ variations and bonding were explored with Fourier transform infrared spectroscopy. X-ray diffraction measurements were carried out to study the crystallinity, structures, and lattice parameters, revealing that the pure TiO2 nanostructures have a tetragonal crystalline structure with an anatase phase, while the Fe:Co3O4 layer possesses a cubic crystalline structure. XRD analysis also showed that the crystallite size increases from 15.9 nm (pure TiO2) to 25.4 nm (FCTO HJ). Optical performance was studied via UV-visible-NIR measurements. The optical parameters of the FCTO HJs were investigated and the nonlinear optical performance of the prepared samples was assessed. Great enhancement of the linear/nonlinear optical performance of the FCTO HJs was achieved compared with the pure TiO2 nanostructures. The results reveal that the Fe:Co3O4/TiO2 nanostructured HJs are recommended for many visible spectrum applications.
Bringing back the core concepts of physiology in an advanced medical school senior elective
Authors: Daroowalla Feroza , Harris David M. , Kibble Jonathan
Published: September 2024

This article presents an innovative approach to integration of physiology core concepts with clinical management using cases of critically ill patients in an online senior elective for medical students. It uses a multidisciplinary faculty conducting a course primarily using case-based learning led by student presentations and discussions of concept maps and order sets.
Induced blood flow oscillations at 0.1 Hz protects oxygenation of severely ischemic tissue in humans
Authors: Davis K. Austin , Bhuiyan Nasrul A. , McIntyre Benjamin J. , Dinh Viet Q. , Rickards Caroline A.
Published: September 2024

We investigated the effects of induced 10-s (0.1 Hz) oscillations in blood flow on forearm tissue oxygenation during severe ischemia. Intermittent inflation of bilateral thigh cuffs was used as a clinically applicable method to drive blood flow oscillations. In support of our hypothesis, 0.1 Hz oscillations in blood flow blunted reductions in forearm tissue oxygenation. These results further support the potential use of oscillatory hemodynamics as a therapeutic intervention for ischemic conditions.
Modulation Instability and Dynamical Analysis of New Abundant Closed‐Form Solutions of the Modified Korteweg–de Vries–Zakharov–Kuznetsov Model With Truncated M‐Fractional Derivative
Authors: Islam Md. Shafiqul , Roshid Md. Mamunur , Uddin Mahtab , Ahmed Ashek
Published: September 2024

In this work, we study the modulation instability (MI) and closed‐form soliton solution of the modified Korteweg–de Vries–Zakharov–Kuznetsov (mKdV‐ZK) equation with a truncated M‐fractional derivative. The mKdV‐ZK equation can be used to describe the behavior of ion‐acoustic waves in plasma and the propagation of surface waves in deep water with nonlinear and dispersive effects in fluid dynamics. To execute a closed soliton solution, we implement two dominant techniques, namely, the improved F‐expansion scheme and unified solver techniques for the mKdV‐ZK equation. Under the condition of parameters, the obtained solutions exhibit hyperbolic, trigonometric, and rational functions with free parameters. Using the Maple software, we present three‐dimensional (3D) plots with density plots and two‐dimensional (2D) graphical representations for appropriate values of the free parameters. Under the conditions of the numerical values of the free parameters, the obtained closed‐form solutions provided some novel phenomena such as antikink shape wave, dark bell shape, collision of kink and periodic lump wave, periodic wave, collision of antikink and periodic lump wave, collision of linked lump wave with kink shape, periodic lump wave by using improved F‐expansion method and kink shape, diverse type of periodic wave, singular soliton, and bright bell and dark bell‐shape wave phenomena by using unified solver method. The comparative effects of the fractional derivative are illustrated in 2D plots. We also provided a comparison between the results obtained through the suggested scheme and those obtained by other approaches, showing some similar solutions and some that are different. Besides, to check of stability and instability of the solution, the MI analysis of the given system is investigated based on the standard linear stability analysis and the MI gain spectrum analysis. With the use of symbolic calculations, the applied approach is clear, simple, and elementary, as demonstrated by the more broad and novel results that are obtained. It may also be applied to more complex phenomena.
Toxicological Evaluation of a Polyherbal Formulation (18KHT01) and Validation of UPLC‐DAD Method for Quality Control
Authors: Pandeya Prakash Raj , Lamichhane Ramakanta , Lamichhane Gopal , Lee Kyung-Hee , Jung Hyun-Ju
Published: September 2024

Background: 18KHT01 is a novel synergistic composition of Quercus acutissima, Camellia sinensis, Geranium thunbergii, and a small portion of Citrus limon. Our previous report demonstrated that the 18KHT01 exhibits potent antiobesity effects, with synergistic antioxidant, antiadipogenic, and antiobesity activities in diet‐induced obese mice. This study explores the toxicity profile and quality control parameters of the 18KHT01 formulation.

Methods: Broad‐spectrum acute and subacute oral toxicity studies were performed using male and female ICR mice. In order to simultaneous analysis of the 18KHT01 formulation, an ultraperformance liquid chromatography coupled with a diode array detector (UPLC‐DAD) method was developed and validated using six marker compounds.

Results: Acute oral toxicity evaluation of 18KHT01, administered at single high doses of 2, 2.5, 3, and 5 g/kg, identified 2 g/kg as the no‐observed adverse effect level (NOAEL). The LD50 (50% lethal dose) and LD100 (100% lethal dose) of 18KHT01 for male ICR mice were 3.99 and 7.77 g/kg, and those for the female mice were 2.94 and 4.70 g/kg, respectively. In addition, a 30‐day repeated dose oral subacute toxicity evaluation indicated that 18KHT01 is safe below 500 mg/kg/day for long‐term administration in ICR mice of either sex. UPLC‐DAD method validation revealed that each calibration curve for the marker compounds showed good linearity, as well as the validation parameters such as precision, specificity, and accuracy met the acceptance criteria.

Conclusion: The present study evidenced the toxicological profile of 18KHT01 polyherbal formulation in mice as well as developed a simple, rapid, and accurate chromatographic method for quality control.
An Ultrathin Multiband Chiral Metasurface for Transmission and Asymmetric Absorption of Electromagnetic Waves
Authors: Sarkar Sayan , Gupta Bhaskar
Published: September 2024

This article presents an ultrathin chiral metasurface which can exhibit multiband asymmetric absorption as well as symmetric transmission in a specific frequency band outside the absorption regions. Unlike most electromagnetic metasurface absorbers, the proposed structure does not have a continuous conducting sheet at the bottom which also allows it to act as a bandpass spatial filter. The metasurface has a substrate thickness of only λhigh/62.5 and λlow/34 at the highest and lowest operational free‐space wavelengths, respectively. The transmission band is centered at 5.5 GHz, and the asymmetric absorption bands are centered at 3, 3.33, and 4.5 GHz, respectively. The operational bands can be tuned as per user requirements. The metasurface has an angular stability of 45° for both TE and TM incidence. It can be used for radar cross‐section (RCS) reduction, electromagnetic shielding, and as a spatial bandpass filter.
Identifying Therapeutic Window for the Ratio of Means under Heteroscedasticity
Authors: Kpeglo Emmanuel D. , Adjabui Michael J. , Jakperik Dioggban
Published: September 2024

In efficacy and safety studies, a vital research concern is to determine the therapeutic window of a pharmaceutical compound. The approach to finding minimum effective dose and maximum safe dose involves multiple comparisons. Generally, in such a problem, a family‐wise error rate is inherited if multiplicity adjustment is not handled properly. This article without a need for multiplicity adjustment formulates a stepwise confidence interval method to identify a therapeutic window of a pharmaceutical compound when equality of variances cannot be assumed and when ratios of variances are known. This article employed Fieller’s method and obtained individual confidence intervals for the identification of the minimum effective dose and maximum safe dose. A simulation study was performed and the results show that the confidence interval method proposed in this article controls the family‐wise error rate strongly. Power increases whenever the ratio of means increases and decreases against higher clinical relevance margins. The proposed procedure was applied to real data and provided optimum results. It was also observed that as both the ratio of means and the sample sizes increase, power increases accordingly.
Diagnostic Accuracy of Bedside Lung Ultrasound in Detecting Traumatic Pneumothorax by Novice Physicians in the Emergency Department of a Tertiary Care Hospital of Nepal
Authors: Malla Monisma , Purna Shrestha Anmol , Prasad Shrestha Shailesh , Shrestha Roshana
Published: September 2024

Introduction. Traumatic pneumothorax is a life‐threatening condition requiring vigilant clinical assessment and urgent management. Lung ultrasound (LUS) is considered to be a safer, rapid, and accurate modality for the early diagnosis of traumatic pneumothorax. The principle objective of this study was to evaluate the diagnostic accuracy of bedside LUS performed by trained novice physicians in the diagnosis of traumatic pneumothorax as compared to supine chest X‐rays (CXRs) and/or computed tomography (CT) scans and/or air leak during needle/tube thoracostomy as composite standard. Methods. It is a prospective, cross‐sectional, single‐blinded study using a nonprobability quota sampling technique. A total of 96 patients presenting to the emergency department (ED) with polytrauma and chest injuries within a period of twelve months were included. The diagnostic accuracy of bedside LUS performed by trained novice physicians was calculated in terms of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) and compared with the composite standard. Results. The sensitivity of LUS in diagnosing traumatic pneumothorax as compared to the composite standard was 100% (95% confidence interval (CI): 59.05%–100.00%), whereas its specificity was 97.75% (95% CI: 92.12%–99.73%). Similarly, the PPV and NPV of LUS were 77.7% (95% CI: 39.99%–97.19%) and 100% (95% CI: 95.85%–100.00%), respectively. Conclusion. The results of the study showed that the application of LUS in detecting traumatic pneumothorax had similar diagnostic accuracy as supine CXR. Bedside LUS is widely available, portable, and inexpensive. It also has the capability of real‐time imaging and can be repeated as necessary with less risk of radiation exposure. Therefore, physicians working in tertiary and rural health institutions must be trained adequately in order to uplift the clinical utility of LUS for the timely and cost‐effective detection of traumatic pneumothorax.
Association between Congenital Anomalies and Late-Onset Bacterial Infections in Neonates Admitted to Neonatal Intensive Care Units in Australia and New Zealand: A Population-Based Cohort Study
Authors: Chughtai Abrar Ahmad , Spotswood Naomi , Strunk Tobias , Parmar Trisha , Schindler Tim , Popat Himanshu , Chow Sharon Sue Wen , Lui Kei ,   The Australian and New Zealand Neonatal Network
Published: September 2024

Introduction: Compromised neonatal intensive care unit neonates are at risk of acquiring late-onset infections (late-onset sepsis [LOS]). Neonates born with congenital anomalies (CAs) could have an additional LOS risk. Methods: Utilising the population-based Australian and New Zealand Neonatal Network data from 2007 to 2017, bacterial LOS rates were determined in very preterm (VPT, <32 week), moderately preterm (MPT, 32–36 weeks), and term (FT, 37–41 weeks) neonates with or without CA. Stratified by major surgery, the association between CA and bacterial LOS was evaluated. Results: Of 102,808 neonates, 37.7%, 32.8%, and 29.6% were born VPT, MPT, and FT, respectively. Among these, 3.4% VPT, 7.5% MPT, and 16.2% FT neonates had CA. VPT neonates had the highest LOS rate (11.1%), compared to MPT (1.8%) and FT (1.8%) neonates. LOS rates were higher in CA neonates than those without (8.2% versus 5.1% adjusted relative risk [aRR] 1.67, 95% confidence interval [CI]: 1.45–1.92). Neonates with surgery had a higher LOS rate (14.2%) than neonates without surgery (4.4%, p < 0.001). Among the neonates without surgery, CA neonates had consistently higher LOS rates than those without CA (VPT 14.3% vs. 9.6% [aRR 1.32, 95% CI: 1.11–1.57]; MPT 4% vs. 0.9% [aRR 4.45, 95% CI: 3.23–6.14]; and FT 2% vs. 0.7% [aRR 2.87, 95% CI: 1.97–4.18]). For the neonates with surgery, CAs were not associated with additional LOS risks. Conclusion: Overall, we reported higher rates of LOS in neonates with CA compared to those without CA. Regardless of gestation, CA was associated with an increased LOS risk among non-surgical neonates. Optimisation of infection prevention strategies for CA neonates should be explored. Future studies are needed to evaluate if the infection risk is caused by CA or associated complications.
A Real-World Comparison of Drug Trough Levels between Patients Experiencing a Secondary Nonimmune Loss of Response and Those Maintaining a Response to Infliximab on Long-Term Maintenance Therapy for Inflammatory Bowel Disease
Authors: Farber Michael , Polman Jeremy , Kohn Nina , Chua Vincent , Swaminath Arun , Sultan Keith
Published: September 2024

Introduction: A secondary loss of response (LOR) to infliximab (IFX) therapy for inflammatory bowel disease (IBD) is typically associated with low IFX trough levels, often with high levels of neutralizing antibodies to IFX (ATI). A small subset of patients on long-term therapy experience a “nonimmune” LOR, without ATI and with desired IFX trough levels ≥5 μg/mL, regarded as a LOR to the mechanism of action of IFX. However, this currently accepted IFX goal level is largely derived from observations of patients within the first year of therapy and may not apply to those on treatment beyond 1 year. Methods: Retrospective review of all IBD patients receiving IFX infusions for ≥12 months with at least 1 IFX trough and ATI measurement beyond 12 months was conducted. Chart review of all patients with absent ATI and an IFX trough ≥5 μg/mL classifies as LOR versus non-LOR based on physician assessment, with a comparison of IFX troughs between the two groups. Results: Of 167 patients using IFX ≥12 months, 13 (7.8%) experienced a nonimmune secondary LOR. The mean duration of IFX use was over 3 years for both LOR and non-LOR patients. The mean IFX trough for those with LOR was greater than for those without LOR, 18.5 μg/mL versus 13.1 μg/mL, p = 0.110. Conclusion: Our results did not demonstrate lower IFX levels among patients experiencing secondary nonimmune LOR on long-term therapy. Our results do not redefine the therapeutic IFX goal levels for those patients on long-term therapy and suggest that underdosing of IFX is not the cause of secondary LOR.
e-Prescribing, Charting, and Documentation for Continuous Renal Replacement Therapy: A Green Intensive Care Unit and Nephrology Initiative
Authors: Baldwin Ian , Chan Jian Wen , Downs Stuart , Palmer Connor
Published: September 2024

Background: Patient care informatics are becoming more advanced with digital capacity and server functionality. The intensive care unit (ICU) is becoming paperless for prescribing, charting, and monitoring care. A further challenge is to include all life sustaining therapies in this digital space. Digital modules and options may be available; however, continuous renal replacement therapies (CRRTs) often require custom design for many nuances. Associated with the COVID pandemic and a surge in the paperless and “green” ICU bedside, we gathered a team to design, develop, and implement a CRRT orders, charting-documentation, and monitoring functionality into our existing Cerner (ORACLE Corp., Austin, Texas, USA) software. Key Messages: This included new approaches to the two-dimensional paper documents used prior and a live dashboard with new metrics and data. The design linked to other relevant CRRT pages such as the master patient fluid balance, pathology results, and medication prescribing. The primary views and function are role-related for medical, nursing, and pharmacy with specific and sensitive input. Following the build and implementation, initial evaluation was positive and led to an audit trail or e-history for prescribers use and provision for concurrent therapies. Clinicians use this digital ordering differently with live data available for “handover” and case discussion. There is scope for research and further links to devices such as personal phones and via an app. Summary: This experience may assist CRRT users design and develop similar prescribing, charting, and monitoring bedside computer opportunities in the desire for digital and green nephrology in the ICU.
The Impact of Radiation Dose and Tumour Burden on Outcomes in Hepatocellular Carcinoma: 11-Year Experience in a 413-Patient Cohort Treated with Yttrium-90 Resin Microsphere Radioembolisation
Authors: Chen Kaina , Tong Aaron K.T. , Moe Fiona N.N. , Ng David C.E. , Lo Richard H.G. , Gogna Apoorva , Yan Sean X. , Thang Sue Ping , Loke Kelvin S.H. , Venkatanarasimha Nanda Karaddi , Huang Hian Liang , Too Chow Wei , Ong Timothy S.K. , Yeo Eng Xuan , Peh Daniel Yang Yao , Ng Ashley W.Y. , Yang Lu , Chan Wan Ying , Chang Jason P.E. , Goh Brian K.P. , Toh Han Chong , Chow Pierce K.H.
Published: September 2024

Introduction: Transarterial radioembolisation (RE) using yttrium-90 (Y-90) microspheres is a widely used locoregional therapy for a broad spectrum of hepatocellular carcinoma (HCC) given its favourable safety profile. We evaluated the real-world outcomes of unresectable HCC treated with resin Y-90 RE and the relationship between tumour absorbed dose and subsequent curative therapy with survival. Methods: Included were consecutive patients treated with Y-90 resin microspheres RE for unresectable HCC between January 2008 and May 2019 at the National Cancer Centre Singapore/Singapore General Hospital. The outcomes were stratified by tumour burden, distribution, presence of portal vein invasion (PVI) and liver function to improve prognostication. Results: The median overall survival (OS) evaluated on 413 included patients was 20.9 months (95% CI: 18.2–24.0). More than half of the patients (214/413, 51.8%) had HCC beyond up-to-seven criteria, and 37.3% had portal vein invasion (154/413, 37.3%). Majority (71.7%) had dosimetry calculated based on the partition model. Patients who received ≥150 Gy to tumour had significantly better outcomes (OS 32.2 months, 95% CI: 18.3–46.4) than those who did not (OS 17.5 months, 95% CI: 13.7–22.7, p < 0.001). Seventy patients (17%) received curative therapies after tumour was downstaged by Y-90 RE and had better OS of 79.7 months (95% CI: 40.4 – NE) compared to those who did not receive curative therapies (OS 17.1 months; 95% CI: 13.5–20.4, p < 0.001). RE-induced liver injury was observed in 5.08% of the patients while 3.2% of the patients had possible radiation pneumonitis but none developed Grade 3–4 toxicity. For HCC without PVI, OS differed significantly with performance status, albumin-bilirubin grade, tumour distribution, and radiation dose; for HCC with PVI, Child-Pugh class and AFP were significant predictors of survival. Conclusions: Treatment outcomes for unresectable HCC using Y-90 RE were favourable. Incorporating tumour burden and distribution improved prognostication. Patients who received tumour absorbed dose above 150 Gy had better OS. Patients who subsequently received curative therapies after being downstaged by Y-90 RE had remarkable clinical outcomes.
Predictive Ability of Rule of 3 in Parathyroid Cancer: Outcomes from a South Asian Cohort
Authors: Pinto Diluka , Dhanda Mallika , Agarwal Amit , He George Hsy , Chia Jolene Li Ling , Parameswaran Rajeev
Published: September 2024

Background: Preoperative diagnosis of parathyroid cancer (PC) where possible allows for en-bloc resection of the tumour, which is associated with excellent prognosis. The rule of >3 (size of tumour larger than 3 cm; corrected calcium more than 3 mmol/L) as proposed by Schulte and Talat has a specificity of 95% in predicting malignancy in parathyroid neoplasms. We looked at the impact of rule of 3 in predicting malignancy and outcomes on intervention in a South Asian cohort. Methods: Patients who underwent parathyroid surgery between 2010 and 2023 at two tertiary referral centres were assessed. Patients with PC were selected and their clinicopathological parameters, treatment modalities, and outcomes were analysed. Results: Thirteen of 336 (3.8%) patients with a mean age of 61.8 (±17.5) years were diagnosed with PC during the study period. The highest mean preoperative values were PTH (92.4 ± 66.27 pmol/L), highest corrected calcium (3.21 ± 0.28 mmol/L), and alkaline phosphatase (419 IU/mL). Nine patients underwent en-bloc excision while the other had focussed parathyroidectomy. Recurrences were recorded in 2 (28.5%) patients over a mean follow-up period of 69 (±48.6) months. One patient with lung metastasis underwent video-assisted thoracic surgery. There was no disease specific mortality in this cohort during the study period. Conclusions: In our experience, the predictive rule of 3 has low sensitivity to suspect PC preoperatively, resulting in limited usefulness in clinical practice. Outcomes appear to be less favourable with higher recurrence rates in cases where less than en-bloc resection is performed.
Understanding the Past and Counterfactual Possibilistic Thinking
Authors: Znakov Viktor V.
Published: September 2024

Background. The article substantiates that today the research emphasis of many psychologists is shifting from understanding the present to analyzing the psychology of understanding the past and the future. Understanding the past is analyzed as a general humanitarian and psychological problem. Counterfactual thinking is considered as a psychological mechanism for understanding the past. Objectives. To analyze the understanding of the past as a function of counterfactual possibilistic thinking. Results. The study delivered an analysis of the role of counterfactual thinking in understanding the past, which did not actually happen, but could include alternative possible events. Counterfactual thinking was considered not as Laplace's consistent description of the human world, but as a complex ambiguous mental formation. It is shown that counterfactual reasoning is a tool of cognition not only for psychologists, but also for historians, linguists, political scientists and researchers in other specialties. The presented analysis allowed to identify and describe five functions of counterfactual possibilistic thinking, manifested in behavior and activity: cognitive, meaning-forming, motivational, moral, and affective-regulatory. Conclusions. The psychological basis of retrospective counterfactual thinking is an appeal to the past, an analysis of the possible but not accomplished options for the development of the events and situations under study. A characteristic feature of the counterfactuals is that counterfactual events are not just something that did not happen, but something that could actually replace what happened.
Socio-psychological determinants of the attitudes of various social groups towards autonomous vehicles as a technology of the future
Authors: Saenko Alexsey Y.
Published: September 2024

Background. Despite the active development of self-driving transport technology conducted by leading companies around the world, people's attitude to such technology remains ambiguous. The problem of the attitudes of individuals and various social groups to this type of transport, as well as the specifics of the socio-psychological determinants of such attitudes, remain insufficiently studied. Objective. To study the socio-psychological determinants of attitudes toward unmanned vehicles depending on professional background, specifics of the residence place, and age group. Study Participants. The study involved 967 people aged 16 to 72 years (Mage = 25.95; SD = 11.83), including 260 men (27%) and 707 women (73%). Methods. Portrait Value Questionnaire, scale “Inclusion” of the Fundamental Interpersonal Relations Orientation questionnaire, Ten-Item Personality Inventory, the methodology of “Trust/distrust of a person to the world, himself and other people”, a questionnaire of attitudes towards technology, the author's methodology for assessing attitudes towards autonomous vehicles. Results. It is shown that attitudes towards unmanned transport differ among people of different professional backgrounds, living in the cities with different population density, and belonging to different age groups. Multiple regression analysis revealed the intrapersonal predictors of such an attitude: an individual value profile, personality traits, basic trust, the need for inclusion in interpersonal communication, and a technical worldview. At the same time, the set of identified predictors depends on the socio-environmental and socio-demographic determinants. The data analysis allowed to develop an empirical model of socio-psychological determinants of a person's attitude towards an unmanned vehicle. Conclusions. The attitude towards an unmanned vehicle is determined by a number of socio-psychological determinants, which include intrapersonal (individual value profile, personality traits, basic trust, the need for inclusion in interpersonal communication and technical worldview), as well as external socio-environmental and socio-demographic determinants (professional background, place of residence and age specifics).
The relationship between parenting styles and adolescents’ educational motivation and emotional state in the context of digitalization
Authors: Kiseleva Maria G. , Komissarenko Anton O. , Vinogradova Valeria D. , Eremina Svetlana A. , Aslanova Margarita S.
Published: September 2024

Background. The emotional state, the length of screen time and the level of educational motivation of schoolchildren are often a matter of concern for many parents. The study examines the relationship between educational motivation, the level of anger, and parenting styles from the adolescents’ point of view. Objectives. Identification and description of the specific interrelations between various aspects of parenting and the teenagers' motivation and anger in the context of global digitalization. Study Participants. The study involved 265 people (54% — female). The average age of the respondents was 13.8 years (M = 13.8, Me = 14, SD = 1.62). Methods. To study parenting styles, teenagers filled out the ad hoc questionnaire “Adolescents about parents”. The motivational and emotional components of the adolescents’ personality were examined by means of Andreeva & Prikhozhan’ questionnaire “Motivation of learning and emotional attitude to learning”. The level of digital engagement of adolescents was assessed on the basis of daily statistics of the average time spent using a mobile phone. Statistical analysis was performed using the general linear model (GLM) method in the Jamovi 2.3.16.0 program. Results. According to the results of the GLM model, the adolescents’ achievement motivation is negatively related to their average screen time. The level of educational motivation of adolescents is positively associated with the positive interest and autonomy provided by their parents. The teenagers’ level of anger is positively associated with directiveness, hostility and inconsistency of parents. According to the Wilcoxon test results, parenting styles such as directiveness, hostility and autonomy are more pronounced in fathers than in mothers. Conclusions. The most favorable parenting style for achieving high academic motivation and reducing the level of anger in adolescents is a pronounced positive interest and autonomy provided by parents along with a low level of directiveness, hostility and inconsistency. Achievement motivation has a negative relationship with the length of teenagers' screen time.
Aristotle and the Ends of Eros, or Aristotle’s Erotic Sublime?
Authors: Bianchi Emanuela
Published: September 2024

While Eros has a central philosophical function in the dialogues of Plato, it all but disappears as a philosophical term in the thought of Aristotle, and is replaced by the more rational and reciprocal relation of friendship, φιλία. This essay asks what becomes of Eros in Aristotle’s thinking, whether as deity, natural or cosmic force, or mode of human relation. Drawing on the ancient epithet of Eros, Ἔρως λυσιµελής, unbinder of limbs, Aristotle’s usages of both ἔρως and λύσις (loosening, unbinding), respectively are traced in their ambivalence for his fundamentally organismic philosophy, insofar as they disturb the organism’s ontological integrity. With the assistance of Kristeva’s notion of the abject, it is argued that while Aristotle’s overt stance is a polemic against eros, his principal metaphysical innovations – the recasting of ἀρχή as divine τέλος, and the separation of material and moving causes – are solutions (λύσεις) to aporias that may involve a traversal of the sublime that is also irreducibly corporeal and erotic.
The Ideal Beloved in the Poems of Kurdish Poets of Īlam
Authors: Omidi Ayoob , Miriasl Kulthum
Published: September 2024

One of the most important themes in lyrical literature is love with the beloved at the core of this topic. The physical beauty of the beloved has a great effect on the lover, leading to describing the beloved’s body as a common tradition in Romantic poetry. The aim of this study is to investigate and analyze the characteristics of the beloved with a descriptive-analytical method, focusing on contemporary Kurdish poetry of Īlam. The results of my study show that the characteristics of the beloved can be categorized into seven items. The descriptions of the beloved in the poems by the poets of Īlam are both beautiful and diverse, totaling about seventy. The portrayal of the beloved is completely realistic; the poets describe her eyes, hair, lips and breasts, respectively. Particularly notable is the emphasis on the beloved’s big intoxicating eyes which captivate the minds of the Kurdish poets. It is interesting to note that in contrast to Persian poetry which favors dark eyes, Kurdish poetry praises blue eyes more. Other differences are the simple language used in Kurdish poetry with less attention to complex imagery as well as the pleasant and intimate relationship with the beloved in Kurdish poetry compared to Persian poetry which employs a much more complicated language and imagery. In many cases, the lover complains about being neglected by the beloved. Poets in Kurdish poems opt for simple imagery, drawing on elements from their surroundings such as flowers, vegetables, constellations and animals. This choice reflects their lifestyle which includes activities like agriculture, animal husbandry and hunting. Overall, the portrayal of the beloved in these poems reflects a deep appreciation for beauty and nature as well as a connection to traditional Kurdish culture and lifestyle.
Codicology and the Transformation of Islamic Law
Authors: Scheunchen Tobias
Published: September 2024

In Islamic law, preponderance (tarjīḥ)—a practical method for mujtahids to resolve legal contradictions (taʿāruḍ) between proofs—has been known in the uṣūl tradition from at least the 10th-century jurist al-Jaṣṣāṣ (d. 370/981). Yet, it is in several 17th and 18th-century Arabic and Ottoman manuscripts of Princeton’s Garrett Collection that we encounter summary-like lists labelled “tarjīḥāt al-bayyināt” (“TB s”), which succinctly compile the complex rules of preponderance. Organized into three-columned lists, on loose leaves, as annotations in the margin or separate textual units, the TB s follow a grammatical and visual layout that made them predictable and recognizable for manuscript readers. This paper examines the TB s as a codicological phenomenon, arguing that they served as a shorthand for legal practitioners familiar with evidentiary law and that their presence suggests a broader transformative process of readers’/legal practitioners’ relationship with codices of positive law at this critical moment in the history of Islamic law.
Gender and Political Compliance Under Authoritarian Rule
Authors: Fan Yingjie , Pan Jennifer , Zhang Tongtong
Published: September 2024

When autocrats do not impose explicit rules of behavior on their subjects, what does political compliance look like? Existing research suggests that such conditions generate uncertainty, leading risk-adverse individuals to self-censor in an effort to minimize the risk of punishment. In this paper, we find that women and men differ in how they express political compliance under conditions of uncertainty. Focusing on Confucius Institute teachers who are given broad objectives but no specific rules of political behavior, we use interviews, a global survey, and an experiment to show that women express compliance by increasing uncensored discussions to persuade host country students toward the Chinese regime’s point of view. In contrast, men comply by vociferously defending the party line and censoring further discussions. These gendered strategies of political compliance are rooted in the differing gender socialization experiences of men and women, who face divergent expectations on how they should interact with others.
Political Cleavages and Changing Exposure to Global Warming
Authors: Gazmararian Alexander F. , Milner Helen V.
Published: September 2024

Why do some countries pass laws to reduce emissions that cause climate change while others do not? We theorize that climate change-related disasters cause politicians to view global warming as more proximate, but whether they have incentives to enact mitigation laws depends on their country’s geographic vulnerability to future damages. We use a spatial integrated assessment model to measure global warming’s local economic effects, which allows us to predict how political leaders respond to disasters based on their vulnerability. An analysis of mitigation laws from 1990–2020 in 155 countries shows that only governments in locations facing the greatest future climate damage react to disasters by passing mitigation policies. Distinct from the historical North-South divide, our findings highlight a growing geographic cleavage in national responses to climate change.
Pharmacy—Physiotherapy Interprofessional Education and Practice
Authors: El Hadidi Seif
Published: September 2024

Interprofessional education (IPE) is an educational technique in which tutors and students from several healthcare disciplines, such as pharmacy and physiotherapy, collaborate to achieve a common goal. IPE has been shown to increase patient outcomes and professional growth among healthcare teams. Pharmacists and physiotherapists have different knowledge bases and skills, both of which are integral to the effectiveness of a collaborative healthcare team. By bringing their respective expertise together in an interprofessional context these healthcare professionals can work to develop increased understanding, respect for each other’s roles, and the ability to collaborate more effectively.
Temperature Excursions in Cold Chain Management—Assessing the Accuracy of Refrigerator Temperature Probes
Authors: Ferraz Kayla , Cato Melissa , Fox Emma , Rawlins Matthew , Misko Jeanie
Published: September 2024

Background: Medications requiring refrigeration for stability are commonly used across hospitals. Temperature-sensitive medications may not have their temperature requirements maintained due to breaches in the cold chain, especially refrigerator failure. This is usually caused by malfunction of the refrigerator unit or by power outage. After multiple power outages at our institution involving refrigerators with temperature probes located in different areas of the refrigerator, we hypothesised that the fixed temperature probe may not accurately reflect the temperature of the medications themselves. Methods: We conducted simulations of power outages in a commonly used medication refrigerator, using additional temperature data loggers, placed on the refrigerator shelf and inside a cardboard box to replicate the temperature inside medication containers to determine if there was a difference in the time to breach cold chain conditions (>8°C) and to return to appropriate refrigerated temperatures (<8°C) when power was restored. Results: All data loggers took a longer time to breach cold chain conditions than the refrigerator probe (12.5 minutes vs 23-26 minutes) but took longer to return to acceptable temperature after power was restored (17.5 minutes vs 70.5-89 minutes). Conclusion: This exploratory research suggests that temperatures vary within a refrigerator depending on the type and location of probe and that medications within may take longer to breach cold chain conditions but also take longer to return to cold chain conditions compared with fixed refrigerator temperature probes. Further research is required to determine whether these variations occur across different sizes/brands of refrigerators and the effect on stability on refrigerated medications.
The Impact of Cybersecurity Attacks on Human Trust in Autonomous Vehicle Operations
Authors: Lim Cherin , Prendez David , Boyle Linda Ng , Rajivan Prashanth
Published: September 2024

Objective

This study examines the extent to which cybersecurity attacks on autonomous vehicles (AVs) affect human trust dynamics and driver behavior.

Background

Human trust is critical for the adoption and continued use of AVs. A pressing concern in this context is the persistent threat of cyberattacks, which pose a formidable threat to the secure operations of AVs and consequently, human trust.

Method

A driving simulator experiment was conducted with 40 participants who were randomly assigned to one of two groups: (1) Experience and Feedback and (2) Experience-Only. All participants experienced three drives: Baseline, Attack, and Post-Attack Drive. The Attack Drive prevented participants from properly operating the vehicle in multiple incidences. Only the “Experience and Feedback” group received a security update in the Post-Attack drive, which was related to the mitigation of the vehicle’s vulnerability. Trust and foot positions were recorded for each drive.

Results

Findings suggest that attacks on AVs significantly degrade human trust, and remains degraded even after an error-less drive. Providing an update about the mitigation of the vulnerability did not significantly affect trust repair.

Conclusion

Trust toward AVs should be analyzed as an emergent and dynamic construct that requires autonomous systems capable of calibrating trust after malicious attacks through appropriate experience and interaction design.

Application

The results of this study can be applied when building driver and situation-adaptive AI systems within AVs.