bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Terrestrial Laser Scanner Accuracy in the Control of Hydrotechnical Structures
Authors: Muszyński Zbigniew , Rybak Jarosław
Published: February 2018

In many cases of monitoring or load testing of hydrotechnical structures, the measurement results obtained from dial gauges may be affected by random or systematic errors resulting from the instability of the reference beam. For example, the measurement of wall displacement or pile settlement may be increased (or decreased) by displacements of the reference beam due to ground movement. The application of surveying methods such as high-precision levelling, motorized tacheometry or even terrestrial laser scanning makes it possible to provide an independent reference measurement free from systematic errors. It is very important in the case of walls and piles embedded in the rivers, where the construction of reference structure is even more difficult than usually. Construction of an independent reference system is also complicated when horizontal testing of sheet piles or diaphragm walls are considered. In this case, any underestimation of the horizontal displacement of an anchored or strutted construction leads to an understated value of the strut’s load. These measurements are even more important during modernization works and repairs of the hydrotechnical structures.

The purpose of this paper is to discuss the possibilities of using modern measurement methods for monitoring of horizontal displacements of an excavation wall. The methods under scrutiny (motorized tacheometry and terrestrial laser scanning) have been compared to classical techniques and described in the context of their practical use on the example hydrotechnical structure. This structure was a temporary cofferdam made from sheet pile wall. The research continuously conducted at Wroclaw University of Science and Technology made it possible to collect and summarize measurement results and practical experience. This paper identifies advantages and disadvantages of both analysed methods and presents a comparison of obtained measurement results of horizontal displacements. In conclusion, some recommendations have been formulated, which are relevant from the point of view of engineering practice.
The Use of Asymptotic Functions for Determining Empirical Values of CN Parameter in Selected Catchments of Variable Land Cover
Authors: Wałęga Andrzej , Młyński Dariusz , Wachulec Katarzyna
Published: February 2018

The aim of the study was to assess the applicability of asymptotic functions for determining the value of CN parameter as a function of precipitation depth in mountain and upland catchments. The analyses were carried out in two catchments: the Rudawa, left tributary of the Vistula, and the Kamienica, right tributary of the Dunajec. The input material included data on precipitation and flows for a multi-year period 1980–2012, obtained from IMGW PIB in Warsaw. Two models were used to determine empirical values of CN
obs parameter as a function of precipitation depth: standard Hawkins model and 2-CN model allowing for a heterogeneous nature of a catchment area.

The study analyses confirmed that asymptotic functions properly described P-CN
obs relationship for the entire range of precipitation variability. In the case of high rainfalls, CN
obs remained above or below the commonly accepted average antecedent moisture conditions AMCII. The study calculations indicated that the runoff amount calculated according to the original SCS-CN method might be underestimated, and this could adversely affect the values of design flows required for the design of hydraulic engineering projects. In catchments with heterogeneous land cover, the results of CN
obs were more accurate when 2-CN model was used instead of the standard Hawkins model. 2-CN model is more precise in accounting for differences in runoff formation depending on retention capacity of the substrate. It was also demonstrated that the commonly accepted initial abstraction coefficient λ = 0.20 yielded too big initial loss of precipitation in the analyzed catchments and, therefore, the computed direct runoff was underestimated. The best results were obtained for λ = 0.05.
The Impact of Socioeconomic Characteristics and Lifestyles on Vitamin D Deficit in Mentally Ill Patients
Authors: Kocic Sanja , Ristic Svetlana , Zivanovic Sandra , Mihailovic Natasa , Curcic Svetlana , Vasiljevic Dragan
Published: February 2018

Mental illnesses put patients at high risk for vitamin D deficit. The aim of the research is to examine the impacts of socioeconomic characteristics and lifestyles on vitamin D deficiency in mentally diseased patients. In this crosssectional study we used blood samples from patients who were treated for mental disorders at Specialist-consultative unit of the Health Center and Clinical Center Kragujevac from May-June 2014. The study used a questionnaire for the assessment of vitamin D status. The study included 220 subjects with different types of mental disorders. Normal values of vitamin D were detected in 16% of patients whereas 64% of patients had vitamin D deficiency. The patients with vitamin D deficit were in average 3 years older than that but the difference is not statistically significant (p>0.05). The patients with vitamin D deficiency were primarily female (p=0.003), people with high-school education from urban environment who lived in bad life conditions (p>0.05). Between patients with and without vitamin D deficiency there is no difference in cigarette consumption, in the number of cigarettes per day, in alcohol usage, in coffee consumption and in nutrition. However, the patients without vitamin D deficiency spent more time outside; during the past year were more exposed to sun and during the past seven days spent more than 30 minutes a day exposed to sunlight (p<0.01). These facts indicate that there is a current need for further research in this area.
Was dem einen sein Ideal, ist dem anderen sein Geschäft
Authors: Beuthien Volker
Published: February 2018

Der nachfolgende Beitrag befasst sich mit der seit jeher umstrittenen und jüngst wieder in der Kita-Rechtsprechung des KG und des BGH aktuell gewordenen Frage, wie sich der wirtschaftliche vom nichtwirtschaftlichen Verein abgrenzen lässt. Er zeigt auf, dass sich in aller Regel auch ideelle Güter kommerzialisieren lassen und dass daher nicht schon der edle Vereinszweck den Einsatz wirtschaftlicher Mittel zu rechtfertigen vermag
Sanierung nach der geplanten EU-Restrukturierungs-Richtlinie
Authors: Müller Hans-Friedrich
Published: February 2018

Am 22.11.2016 hat die EU-Kommission ihren mit Spannung erwarteten Vorschlag für eine Richtlinie über einen präventiven Restrukturierungsrahmen veröffentlicht. Er enthält konkrete Vorgaben für ein europaweit harmonisiertes vorinsolvenzliches Sanierungsverfahren. Die Umsetzung hätte für das deutsche Recht ganz erhebliche Folgen, die in dem folgenden Beitrag näher beschrieben werden. Der Verfasser begrüßt die Initiative der Kommission im Grundsatz, sieht aber noch Änderungsbedarf. Die geplante Richtlinie sollte sich auf die Regelung der für die Funktionsfähigkeit des Verfahrens wesentlichen Punkte konzentrieren. Sehr kritisch zu beurteilen sind die vorgesehenen Eingriffe in das Gesellschafts- und Gesellschaftsinsolvenzrecht der Mitgliedstaaten. Diese problematischen Maßnahmen sollten im weiteren Gesetzgebungsverfahren noch einmal überdacht werden, ohne das Vorhaben insgesamt in Frage zu stellen.
Der Aufsichtsrat von Kreditinstituten drei Jahre nach dem „Regulierungstsunami“ – eine Bestandsaufnahme
Authors: Binder Jens-Hinrich
Published: February 2018

Im Gefolge der globalen Finanzkrise sind als Teil der reformierten aufsichtsrechtlichen Anforderungen an die interne Corporate Governance der Kreditinstitute auch die Vorgaben für Zusammensetzung, Organisation und Aufgaben des Aufsichtsrats der Kreditinstitute umfassend neu geregelt worden. § 25 d KWG, welcher der Umsetzung unionsrechtlicher Vorgaben für das „Leitungsorgan in seiner Aufsichtsfunktion“ dient, bildet dabei nur einen Teil der Problematik ab. Von größter praktischer Bedeutung sind daneben – erst jüngst neu gefasste – Leitlinien der Europäischen Bankenaufsichtsbehörde (EBA) und Verlautbarungen der EZB als zuständige Aufsichtsbehörde im Einheitlichen Aufsichtsmechanismus (SSM), die die gesetzlichen Vorgaben sehr kleinteilig ausdifferenzieren. Der Beitrag untersucht vor diesem Hintergrund, wie sich die damit ausgelöste Dynamik in den aktienrechtlichen Bezugsrahmen für die Tätigkeit des Aufsichtsrats in der Rechtsform der AG einfügt, die angesichts der vom internationalen Leitbild abweichenden dualistischen Unternehmensverfassung besondere Anpassungsprobleme bereitet.
Studying Media Polarity Effects on the Photo-Physical Behaviors of Organometallic Complexes with Azo-Containing Schiff-Base Ligands
Authors: Khadem Sadigh Mahsa , Hasani Majid , Rahimpour Jinous
Published: February 2018

Solvent molecules as an important factor can modify the photo-physical behavior of organometallic complexes. For precise investigation, in this paper, the spectral behavior of some groups of copper complexes with different substituents were studied in various solvent media. In this case, the linear solvation energy relationships concept was used for determination of various contribution of media induced specific and non-specific interactions on the photo-physical behavior of various forms of organometallic complexes with azo-containing Schiff-base dyes. Moreover, the calculated dipole moments indicate that samples with different forms tend to have polar structure in the excited state as compared to those in the ground state. By exploiting of calculated dipole moments and obtained quantitative results in the ground and excited states, the dominant solvent induced resonance structures were also estimated. The obtained experimental results can give more information about how these samples can behave in various physical, chemical and biological phenomena.
Role of Tryptophan in Protein–Nanocrystals Interaction: Energy or Charge Transfer
Authors: Mittal Mona , Gautam Saurabh , Chowdhury Pramit Kumar , Deep Shashank , Sapra Sameer
Published: February 2018

The understanding of the interaction between the semiconductor nanocrystals (NCs) and the proteins are essential for design and fabrication of nanocomposites for application in the field of biotechnology. Herein, we have studied the interaction between CdTe NCs and the proteins by steady-state and time-resolved photoluminescence (PL) spectroscopy. The steady-state PL intensity of CdTe NCs is quenched and enhanced in the presence of lysozyme and bovine serum albumin, respectively. However, the PL intensity of CdTe NCs is not affected with α-synuclein, indicating the role of tryptophan moiety in the protein–NCs interaction. The detailed analysis of PL data allows us to elucidate the dominant mechanism of interaction, i.e. charge or energy transfer, depending on the location of tryptophan residues in the protein. Assuming a Poisson statistic of lysozymes around NCs, the Poisson binding model is used to understand the kinetics of charge transfer from CdTe NCs to the lysozyme. It provides the average number of lysozymes present on the surface of one CdTe NC.
Elsewhere
Authors: Qureshi Bilal
Published: February 2018

Columbus is the feature-film debut of Korean American director Kogonada, known to cinephiles for his video essays on auteurs. His film stars John Cho (Star Trek, Harold and Kumar) as Jin, a grieving son arriving in Indiana from Seoul to care for his ailing father, a renowned scholar of modernist architecture. The architectural imagery in Columbus serves as something more: it provides narrative punctuation, forming elegantly placed interludes in a moving story of the real people who live in and visit today's Columbus. It's a film about the forgotten heartland ambitions of young dreamers like Casey who face the precarious economic realities of a city beyond the thriving coasts. At a time when ideas of diversity, Middle Americanness, and technology-fueled attention-deficiency sit at the center of national cultural debates, Columbus elegantly glides across all those themes, speaking to yet not confronting them.
Recurrent Themes, Entangled Histories, and Cultural Affinities: Balkan Cinema at the 58th Thessaloniki International Film Festival
Authors: Grgic Ana
Published: February 2018

Since 1993, Thessaloniki International Film Festival has been home to the Balkan Survey program, showcasing new films from the region as well as presenting retrospectives of the work of significant Balkan film directors. Now in its 24th edition, the Balkan Survey offered a survey of new and exciting films from the region, and also included a special tribute on film adaptations. This special tribute, “From Words to Images: Balkan Literature and Cinema,” presented, both new and old, important and ground-breaking works from the archival collections and film heritages of each nation. This selection of landmark works from Balkan cinema comes at a mature moment when the Balkan Survey has almost completed a generation of screenings, now celebrating the best of Balkan cinema through the tribute to film adaptations. However, access to archival films in the Balkans still remains a challenge. The lack of formal cooperation and infrastructure in the region has a detrimental effect on the preservation and distribution of Balkan filmic works beyond national confines. Clearly, an effort on the part of governmental and (hopefully) private institutions will be instrumental in creating a sustainable network and frameworks of cooperation for the sharing and screening of these films.
Yamagata International Documentary Film Festival: Blending Tradition with Modernity
Authors: Berger Sally
Published: February 2018

Every two years since 1989, the Yamagata International Documentary Film Festival takes place in Yamagata City, three hours by bullet train north of Tokyo. It is the longest running Asian documentary film festival and retains its status as a key locus point for showcasing Asian nonfiction film along with an international roster. This report examines the festival's history, relationship to Ogawa and other masters of Japanese documentary, and report on its contemporary Japanese, Asian and International programming. What is the stature of the festival today and whom does it serve?
Expression of Rho Kinase and Its Mechanism in the Left Atrial Appendage in Patients with Atrial Fibrillation
Authors: Chen Yongqing , Su Fangju , Han Juanping , Jiao Piqi , Guo Wenyun
Published: February 2018

Aim: To study the expression of Rho kinase (Rho associated coil forming protein kinase-1, ROCK-1) and its substrate myosin phosphatase target subunit 1 (myosin phosphatase target subunit-1, MYPT-1), connexin 40 (Cx40) and connexin 43 (Cx43) in the left atrial appendage of patients with atrial fibrillation, and explore the role of ROCK signaling pathway in patients with atrial fibrillation and its underlying mechanism. Methods: 40 patients undergoing open heart surgery were divided into two groups; atrial fibrillation group (AF group) and sinus rhythm group (SR group). About 100 mg of left atrial appendage tissue was taken during surgery and quickly frozen in liquid nitrogen. Immunohistochemistry and western blot were performed to evaluate the expression and location of ROCK-1, MYPT-1, Cx40 and Cx43 in the left atrial appendage tissue. Results: The results indicated that the expression of ROCK-1, MYPT-1, and Cx40 in the left atrial appendage in patients with atrial fibrillation was significantly upregulated (P < .01), the difference in the two groups was statistically significant, and ROCK-1, Cx40, and MYPT-1 expression in the AF group were higher than those in sinus rhythm group; there was a weakly positive expression of Cx43 protein in the AF group and sinus rhythm group, the difference was not statistically significant, and ROCK-1 and MYPT-1 expression showed a significant positive correlation (r = 0.968, P < .05), MYPT 1 and Cx40 protein expression was also positively correlated (r = 0.983, P < .05). Evidence in the left atrial appendage tissue of patients with atrial fibrillation showed that some proteins in Rho/ROCK pathway were upregulated, and MYPT-1 and Cx40 protein expression in AF group were significantly higher than that of SR group, which was also positively correlated; Cx43 showed a weak positive expression in both the SR group and AF group, which indicates that Rho kinase may induce expression of Cx40 by phosphorylation of MYPT-1; Cx43 may not be involved, suggesting that Rho kinase signaling pathway may activate and play an important role in the pathogenesis of atrial fibrillation lesions.
Reoperative Cardiac Surgery: Part I – Preoperative Planning
Authors: Tribble, MD Curt
Published: February 2018

While reoperative cardiac surgery has become safer in recent years, it is still more difficult and dangerous than a primary operation. In a recent review of the Cleveland Clinic’s experience, 7% of the patients undergoing cardiac reoperations had major intraoperative adverse events (IAEs). In that report, if an IAE occurred, there was a 5% mortality and a 19% incidence of myocardial infarction (MI), stroke, or death [Roselli 2011]. Those are sobering statistics, particularly when reported by one of the busiest cardiac surgical services in the world. The take-home message is that reoperative cardiac surgery is riskier than primary cardiac operations and that there are strategies that should be employed at each juncture to lower the risks of a reoperation.However, many of these strategies and recommendations have been more implicit than explicit. In fact, surprisingly little has been written about reoperative cardiac surgery. Thus, it seems appropriate to collect some of the lessons, adages, tricks, and tools that might make reoperations a click safer.
Regulation of Circadian Behavior by Astroglial MicroRNAs inDrosophila
Authors: You Samantha , Fulga Tudor A , Van Vactor David , Jackson F Rob
Published: February 2018

You et al. describe the first genome-wide analysis of glial microRNAs in the context of circadian behavior. They identified multiple miRNAs whose manipulation...

We describe a genome-wide microRNA (miRNA)-based screen to identify brain glial cell functions required for circadian behavior. To identify glial miRNAs that regulate circadian rhythmicity, we employed a collection of “miR-sponges” to inhibit miRNA function in a glia-specific manner. Our initial screen identified 20 glial miRNAs that regulate circadian behavior. We studied two miRNAs, miR-263b and miR-274, in detail and found that both function in adult astrocytes to regulate behavior. Astrocyte-specific inhibition of miR-263b or miR-274 in adults acutely impairs circadian locomotor activity rhythms with no effect on glial or clock neuronal cell viability. To identify potential RNA targets of miR-263b and miR-274, we screened 35 predicted miRNA targets, employing RNA interference-based approaches. Glial knockdown of two putative miR-274 targets, CG4328 and MESK2, resulted in significantly decreased rhythmicity. Homology of the miR-274 targets to mammalian counterparts suggests mechanisms that might be relevant for the glial regulation of rhythmicity.
The Evolution of Science in a Latin-American Country: Genetics and Genomics in Brazil
Authors: Salzano Francisco M
Published: February 2018

This article begins with a brief overview of the history of Brazil and that of Brazilian science, from the European discovery of the country in 1500 up to the early 21st century. The history of the fields of genetics and genomics, from the 1930s, is then first examined from the focal point of the lives and publications of the three persons who are generally considered to be the founders of genetics in Brazil (C. A. Krug, F. G. Brieger, and A. Dreyfus), and then by 12 other researchers up to 1999. The area of molecular genetics and genomics from 2000 to present is then described. Despite the problems of underdevelopment and the periodical political and economic crises that have affected life in Brazil, the fields of genetics and genomics in Brazil can be regarded as having developed at an appropriate pace, and have contributed in several major ways to world science.
Finite mixture of compositional regression with gaussian errors
Authors: Shimizu Taciana , Louzada Francisco , Suzuki Adriano
Published: February 2018

In this paper, we consider to evaluate the efficiency of volleyball players according to the performance of attack, block and serve, but considering the compositional structure of the data related to the fundaments. The finite mixture of regression models better fitted the data in comparison with the usual regression model. The maximum likelihood estimates are obtained via an EM algorithm. A simulation study revels that the estimates are closer to the real values, the estimators are asymptotically unbiased for the parameters. A real Brazilian volleyball dataset related to the efficiency of the players is considered for the analysis.
Uso do laser de baixa potência em estrias de distensão: ensaio clínico randomizado controlado
Authors: Busatta Bethina Bernardon , Medeiro Karoline Calichio , Velozo Lorrainy Rufino , Kakihata Camila Mayumi Martin , Soares Francyelle dos Santos , Azevedo Márcia Rosângela Buzanello , Bertolini Gladson Ricardo Flor
Published: February 2018

AIMS: To analyze the effects of low-level laser therapy (660nm) in the treatment of striae alba.METHODS: A randomized clinical trial was conducted with 20 women equally divided into a control group and a treatment group. For inclusion, they should have striae alba in the gluteal region and accept to participate in the study. Exclusion criteria were other treatment for striae, pregnancy, steroid use, smoking, cancer diagnosis, hemorrhagic areas on the skin, diagnosis of epilepsy, diagnosis of thrombosis, or any cognitive impairment. Twelve applications of 660 nm laser were performed for four weeks. After another four weeks of follow-up, a reevaluation was performed. After each application, photos were taken from the region to evaluate the size of the striae by means of scanned planimetry, which calculates the percentage of area occupied by the striae. For this evaluation, the photos taken at the first application (AV1), the sixth (AV2), the 12th (AV3) and the last evaluation, after four weeks of treatment completion (AV4), were used. Qualitative evaluations were also performed by touch (depth) and visual inspection (hue and size).RESULTS: The analysis by planimetry showed that there was no difference between the area occupied by the striae when comparing the various evaluations of the same group, until the AV3. However in AV4 (four weeks after the last laser application) of the treatment group, there was a statistically significant decrease of the stria area in relation to AV1. In the control group, there was no difference between AV4 and the other evaluations. In the comparison between the two groups, there was no difference in the first three evaluations. However in AV4 the treatment group showed a smaller area of the striae in relation to the control group. In the qualitative analysis the treated group had lower visibility and less depth of the striae to the touch.CONCLUSIONS: Therapy with 12 sessions of low-level laser for four weeks had a positive effect on the treatment of striae alba, with results becoming evident only four weeks after the last application. The 660 nm laser showed to be a non-invasive, painless and fast-applied method.
Anemia e índices de atividade de doença em mulheres com artrite reumatoide
Authors: Scheffel Thamiris Becker , Prado Aline Defaveri do , Staub Henrique Luiz , Silveira Inês Guimarães da , Bender Ana Lígia
Published: February 2018

AIMS: To evaluate disease activity indexes in female patients with rheumatoid arthritis, Anemic and Non-anemic, correlating with hemoglobin levels.METHODS: A cross-sectional study involved women with rheumatoid arthritis classified into two groups: 1) Anemic (hemoglobin <12 g/dL) and 2) Non-anemic. Disease activity was measured by Disease Activity Index (DAS28), using different inflammatory markers:  Erythrocyte Sedimentation Rate (ESR) and C-reative Protein (CRP).  This score also uses the number of swollen and painful joints and an overall assessment of the disease on Visual Analogue Scale (VAS). An assessment of functional capacity by the Health Assessment Questionnaire (HAQ) was also performed. The statistic used Student’s t-Test, Mann-Whitney, Wilcoxon, Fisher, likelihood ratio and Spearman correlation tests. It was considered significant p <0,05.RESULTS: Twenty-four patients were included, eight of Anemic group and 16 of Non-anemic. The groups were similar in terms of clinical, demographic and treatment characteristics, differing only in relation to rheumatoid factor, positive in all anemic participants and in 56,2% of non anemic participants. DAS28 ESR (median 6,05; interquartile range [IQR] 5,21-7,76), DAS28 CRP (median 4,32; IQR 3,98-5,92) and VAS (median 66,50 mm; IQR 54,75-80,50) were significantly higher in Anemic group. DAS28 ESR (-0,418) and VAS (-0,426) showed a significant negative correlation with hemoglobin level. DAS28 ESR and DAS28 CRP values were different in the same group, showing a discrepancy in the categorization of disease activity. In Anemic group, DAS28 ESR value (median 6,05; IQR 5,21-7,76) was higher in relation to DAS28 CRP (median 4,32; IQR 3,98-5,92). A less discrepant increase of DAS28 ESR (median 4,01; IQR 3,05-5,68) compared to DAS28 CRP (median 3,06; IQR 2,18-4,66) was observed in Non-anemic group.CONCLUSIONS: Anemia was associated with worse disease activity indexes in women with rheumatoid arthritis, correlated with greater pain intensity and increase of DAS28 ESR score.
Microcefalia por toxoplasmose congênita em tempos de epidemia por Zika vírus no Brasil
Authors: Bahia-Oliveira Lilian Maria Garcia , Liborio-Neto Adail Orrith , Dudus Marta Maciel
Published: February 2018

A case of congenital toxoplasmosis with microcephaly occurred during the epidemic by Zika virus in Brazil, and only being diagnosed as toxoplasmosis at seven months of age, is described. This case illustrates the pertinence and urgency for the implementation of specific public policies for prevention, diagnosis and treatment for toxoplasmosis acquired during pregnancy, and shows that when the subject is microcephaly due to congenital infections in Brazil, one must be attentive to other possibilities besides Zika virus infection; in particular to congenital toxoplasmosis, which is highly prevalent in our country, and if diagnosed and treated in due course, irreversible neurological and ocular damage may be avoided. We fully support the Ministry of Health ordinance that makes it compulsory to notify cases of gestational and congenital toxoplasmosis in the country. The actions that will be implemented should result in a specific national program for gestational and congenital toxoplasmosis, which will benefit children throughout the country through preventive health education, screening and treatment for pregnant women and newborns.
Evaluación de arvenses como hospedantes alternos de nematodos fitoparásitos en cafetales en Costa Rica
Authors: Peraza-Padilla Walter , Orozco-Aceves Martha
Published: February 2018

There is potential for weeds to be alternative hosts of plant-parasitic nematodes (PPN), but a methodology that assesses the phytosanitary risk derived from the presence of weeds in plantations is not available. This research was conducted in order to determine if the presence of weeds in coffee plantations (organic and conventional) represented a phytosanitary risk due to their role as alternative hosts of PPN. The research was developed into two plantation located in Aserrí, San José, Costa Rica during August, 2010. The most important weeds were identified in the plantations, also nematodes of the genera Meloidogyne, Pratylenchus and Helicotylenchus were quantified in soil and roots from selected weeds and coffee plants. A permutational analysis of variance was executed in order to determine the genera of PPN that significantly differed from the ones found in weeds to the ones found in coffee plants. Based on these results, the weeds were classified as: reservoir, trap crop, or weak host of PPN. This classification criterion, in addition to life cycle and type of parasitism of the PPN were used to assign numerical values to the weeds. The values were used to calculate the Phytosanitary Risk Index (PRI) that acquired a maximum value of 10 for the weed Piper umbellatum in the organic plantation, and a maximum value of 24 for Commelina diffusa, Emilia fosbergii, Spananthe paniculata, Delilia biflora, and Spermacoce hirta in the conventional plantation. The results indicated that from a nematological perspective the presence of these weeds in coffee plantation could be a potential risk for coffee plants
A Randomized Phase II Study of Metformin plus Paclitaxel/Carboplatin/Bevacizumab in Patients with Chemotherapy-Naïve Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer
Authors: Marrone Kristen A. , Zhou Xian , Forde Patrick M. , Purtell Michael , Brahmer Julie R. , Hann Christine L. , Kelly Ronan J. , Coleman Barbara , Gabrielson Edward , Rosner Gary L. , Ettinger David S.
Published: February 2018

Background

In the absence of a targeted oncogenic driver mutation or high programmed death-ligand 1 expression, systemic therapy with platinum-based doublet chemotherapy with or without bevacizumab has been the standard treatment in advanced or metastatic non-small cell lung cancer (NSCLC). Metformin has been shown to have antitumor effects via a variety of insulin-dependent and insulin-independent mechanisms and to be potentially synergistic with chemotherapy.

Materials and Methods

This open-label single-center phase II study (NCT01578551) enrolled patients with chemotherapy-naïve advanced or metastatic nonsquamous NSCLC and randomized them (3:1) to receive carboplatin, paclitaxel, and bevacizumab with (Arm A) or without (Arm B) concurrent metformin for four to six cycles followed by maintenance therapy with bevacizumab ± metformin continued until disease progression, intolerable toxicity, or study withdrawal. The primary outcome was 1-year progression free survival (PFS). Secondary outcomes included overall survival, response to therapy, and toxicity.

Results

A total of 25 patients were enrolled from August 2012 to April 2015, of whom 24 received at least one cycle of therapy administration. The study was stopped early due to slow accrual and changes in standard first-line therapy of advanced NSCLC. The 1-year PFS on Arm A (n = 18) was 47% (95% confidence interval [CI]: 25%–88%), which exceeded the historical control 1-year PFS of 15%. Median overall survival of patients treated on Arm A was 15.9 months (95% CI: 8.4–not available [NA]) and 13.9 months (95% CI: 12.7–NA) on Arm B. There were no significant differences in toxicity between the study arms.

Conclusion

To the authors' knowledge, this is the first study to show a significant benefit in PFS with the use of metformin in this patient population and is a signal of efficacy for metformin in advanced NSCLC.

Implications for Practice

The anticancer effects of metformin continue to be elucidated. To the authors' knowledge, this is the first trial in nondiabetic advanced non-small cell lung cancer patients to show a significant change in outcome with the addition of metformin to standard first-line chemotherapy. Well tolerated and widely available, metformin is a drug that should be considered for further study in the lung cancer treatment landscape.
Synthesis of AuNPs with catalytic and antioxidant properties using the dreaded weed mimosa
Authors: Pirathiba S , Ganaie Sami Ullah , Rajalakshmi R , Abbasi Tasneem , Abbasi Shahid Abbas
Published: February 2018

The paper presents a method for the biomimetic extracellular synthesis of gold nanoparticles (AuNPs) by using the aqueous extracts of all the main parts (leaves, stem and roots) of the highly invasive terrestrial weed mimosa (Mimosa pudica). Aqueous extracts of each of these parts served as reducing as well as stabilizing agents. The effects of key variables that influenced the shape and/or size of the AuNPs – mainly metal-extract stoichiometry, temperature and pH – were studied with the help of ultraviolet–visible spectrophotometry, X-ray diffraction, energy-dispersive X-ray spectroscopy, electron microscopy and Fourier transform infrared spectroscopy. The efficacy of the AuNPs in free radical scavenging and as catalyst was witnessed. The studies thus provide a template for scaling up AuNP synthesis and utilizing it. Given the fact that M. pudica is freely available in large quantities, with no other recognized use, the present method opens up a possibility for its large-scale utilization in synthesizing AuNPs of tunable shapes and sizes in a rapid, non-polluting, energy-frugal and inexpensive manner.
Briefing: Design and construction of Canary Wharf temporary floating road, London, UK
Authors: Ohl Cliff , Radcliffe Benjamin , Richardson Harvey , Handley-Collins Ashley
Published: February 2018

The Canary Wharf floating road was constructed to provide access for articulated lorries to a congested construction site, the Newfoundland project in central London. The 80 m × 15 m floating road incorporates a modular steel roadway deck spanning over 81 modular Linkflote pontoons. Linkspan ramps for vehicle access and a pontoon lateral restraint system are designed to minimise impact on the existing dock wall (grade II listed) by connecting to the Newfoundland Building's ground-floor structure (under construction). With constructability a principal issue, all structural components were designed as modular steel assemblies, transported using standard road vehicles and assembled on site. A structural model, compatible with building information modelling, including all components and interfaces, was produced to develop the design, produce fabrication and installation drawings and ensure integration with the permanent works. The floating road provides an essential platform for transport, materials handling and storage for the Newfoundland project.
Fatigue experiment of sectional integrated model of a suspension bridge
Authors: Zeng Yong , Zhong Huadong , Tan Hongmei , Yu Qu
Published: February 2018

Previous fatigue tests have placed emphasis on single components such as the anchorage zone, orthotropic steel deck or hanger of suspension bridges, and the test results were thus influenced by many boundary conditions. However, the stresses of such components are complex and boundary conditions have a marked impact on fatigue test results. To evaluate the safety and durability of key structural details and verify the design rationality, fatigue tests on a 1:4 scale integrated model were carried out; the model included the main cable, anchorage zone, hangers and box girders. The experiment results showed that stress redistribution in the integrated model after fatigue loading cycles was not obvious, the principal stresses of static load tests during the fatigue experiment were a little different and the relationship between displacement and static load was approximately linear. In each static load test, displacements and stresses in the process of loading and unloading showed good symmetry and recoverability, indicating that the integrated model was in the elastic stage. Fatigue cracks were not found in key structural details under fatigue loading, so structural fatigue performance may meet the design requirements. The integrated model fatigue test can more truly reflect the actual fatigue performance of a cable–anchorage–hanger–girder structure and can provide some guidance on actual projects.
Conhecimento científico entrelaçando prática sociocultural do filó e relações de hospitalidade: um estudo bibliográfico
Authors: Cappellano dos Santos Marcia Maria , Camilotto Samara
Published: February 2018

O filó, encontro realizado na zona rural à noite, geralmente aos sábados, congregando famílias, amigos e vizinhos, é uma prática sociocultural que faz parte da história da imigração italiana no estado do Rio Grande do Sul. Nele, as pessoas conversavam sobre seus cotidianos, comiam e bebiam o que, através do trabalho na roça, era fornecido pelo solo; exprimiam sua fé na religião através da reza, praticavam jogos, faziam artesanato para decoração das casas e vestimentas, ou então confeccionavam ferramentas para o trabalho no campo, e também cantavam sobre suas dores e sobre suas esperanças. Laços de hospitalidade concretizavam a prática como encontro de comunhão, celebração e trocas. Partindo desse contexto, este artigo tem o objetivo de identificar e descrever estudos que abordam direta ou indiretamente o filó e que o analisam pelo viés da hospitalidade. Assim, esta pesquisa caracteriza-se como bibliográfica, tendo sido realizada em livros, artigos, dissertações, teses e anais de eventos. Os resultados apontam que apenas um estudo tem como foco central o filó, sendo que os demais descrevem a prática no decorrer do trabalho como informação ou resultado adicional às pesquisas realizadas. Outros acessos advieram provavelmente de link com o radical “filo”, remetendo, dentre outras, a produções relacionadas a filosofia, filologia, filogenética. Tal lacuna configura-se assim como uma justificativa para o desenvolvimento de pesquisa de mestrado em andamento, da qual a prática sociocultural do filó compõe o objeto de estudo.
Campos do Jordão a procura da hospitalidade urbana
Authors: Fedrizzi Valéria Luiza Pereira , Mendes Bruna Castro
Published: February 2018

Os estudos da hospitalidade e seus desdobramentos possibilitam diversas análises, em âmbito nacional e internacional. O ensaio pretendeu continuar o aprofundamento dos lugares de hospitalidade, baseado nas categorias construídas por Grinover (2013), acerca de sua discussão dos elementos básicos para a interpretação da hospitalidade urbana na cidade. A cidade case objeto de estudo foi o destino turístico Campos do Jordão, localizada no estado de São Paulo (Brasil). Campos do Jordão em seu processo evolutivo ampliou sua oferta e infraestrutura turística. Pretendeu-se analisar a hospitalidade urbana, com enfoque no turismo na cidade, sendo a base às categorias: acessibilidade; legibilidade; identidade; urbanidade; qualidade de vida; e a cidadania (GRINOVER, 2007 e GRINOVER, 2013). A pesquisa utilizou-se de dados extraídos do Observatório de Turismo de Campos do Jordão. Quanto à pesquisa de campo, essa se baseou na interpretação de dados tabulados, via aplicação de um questionário de perguntas abertas, composto por cinco questões, sendo amostrados 230 questionários. No caso estudado, as interpretações iniciais sinalizam, que para o processo de hospitalidade urbana ocorra na cidade, fundamentalmente, observa-se a necessidade de uma política de hospitalidade no sentido de aproximação dos anfitriões aos espaços hospitaleiros e, ainda à aproximação dos anfitriões com os turistas, nas relações baseadas na hospitalidade comercial, frente à hospitabilidade percebida nos agentes prestadores de serviços turísticos.
As esferas pública e doméstica da hospitalidade na Jornada Mundial da Juventude Rio 2013 na percepção de estrangeiros
Authors: Villa Gonzalez Luciana Thais , Mariz Cecília Loreto , Gracino Junior Paulo
Published: February 2018

Este artigo tem como objetivo principal apresentar dados relativos a uma pesquisa realizada durante a Jornada Mundial da Juventude Rio 2013 (JMJ Rio 2013) acerca da percepção dos participantes estrangeiros do evento em relação à hospitalidade doméstica e pública ofertadas pela cidade do Rio de Janeiro e sua população. A Igreja Católica carioca promoveu antes e durante o evento a hospedagem de participantes na casa dos habitantes da cidade, bem como, ocupou com diversas atividades as mais variadas regiões do município, usualmente, esquecidas pelos turistas. Desta forma, o bem receber no lar e na cidade tornaram-se aspectos fundamentais da JMJ Rio 2013 para os participantes deste evento. A pesquisa teve caráter quanti-qualitativo uma vez que utilizou como instrumentos de coleta de dados um survey aplicado a 550 participantes estrangeiros inscritos oficialmente no evento durante os seis dias de sua duração e a realização de 17 entrevistas semiestruturadas. Por meio dos dados coletados, percebeu-se que a hospitalidade doméstica deu sentido profundo e significativo a experiência do evento vivida pelos entrevistados e amenizou aspectos considerados negativos por estes em relação a hospitalidade pública.
Roteiro turístico e experiência: uma análise técnico operacional do guiamento e da interpretação patrimonial no programa “olha! Recife”
Authors: Cisne Rebecca , Guggelberger Darcilene , Esteves Dione
Published: February 2018

Esta pesquisa tem como objetivo analisar os guiamentos nos roteiros do programa “Olha! Recife”, a luz do funcionalismo, destacando as categorias tradicionais (funções manifestas) e contemporâneas (funções latentes) do guiamento e da interpretação patrimonial, para que possa saber se o guiamento realizado durante os roteiros turísticos do programa “Olha! Recife” considera as necessidades contemporâneas do Turismo quando da interpretação patrimonial atuando como mapas cognitivos do texto urbano permitindo a geração de experiência marcante para o turista cidadão. A coleta de dados foi feita por meio de observação sistematizada nas modalidades a pé e de ônibus do programa. Os resultados revelam que os guias têm competências técnicas e comportamentais tradicionalmente esperadas, mas ainda precisam ter mais aprimoramento das competências técnicas de interpretação patrimonial para que se possa resultar em lugarização do turista-cidadão.
Breakout Session: Fight for Your Right to Copy: How One Library Acquired the Copyright Permissions Service and Reduced Students’ Costs. Presented by Emily Riha, Copyright Permissions Coordinator, University of Minnesota.
Authors: Strittmatter Connie
Published: February 2018

Emily Riha, Copyright Permissions Coordinator at the University of Minnesota, presented at the 2017 Kraemer Copyright Conference her experience when the process of securing copyright permissions moved from Printing Services to the University Libraries.
Breakout Session: Getting Moral Rights Right. Presented by Kevin Smith, Dean of Libraries, University of Kansas.
Authors: Wright Andrea M.
Published: February 2018

This brief piece records the breakout session Getting Moral Rights Right by Kevin Smith from the 2017 Kraemer Copyright Conference.
Breakout Session: View from the Bleachers: Applied Skills in Finding and Using Free Media Resources. Presented by Barbara Waxer, Santa Fe Community College.
Authors: Landis Cyndi Lea
Published: February 2018

The purpose of copyright is to promote the creation of creative content; however, copyright confusion can make students and creators feel limited or intimidated from using media in their work. At the 2017 Kraemer Copyright Conference, Barbara Waxer presented a resourceful session about copyright and Creative Commons licensing through the eyes of information consumers and creators who in essence just want to know whether they can use a certain song, photo, or media source. Waxer’s breakout session highlighted the decision-making process for the copyright conscious by presenting easy-to-use flow charts and online resources that clearly explain Creative Commons licensing, with hopes that librarians can use these tools for teaching copyright at large.
Conference Session II: Creation or Evolution: Can Copyright Bring the Peace? Presented by Kenneth D. Crews, attorney, Gipson Hoffman & Pancione
Authors: Nelson Marley C.
Published: February 2018

Dr. Kenneth Crews gives an overview of the history of copyright law, using creation and evolution as touchstones for the quick leaps and long crawls made in this discipline.  Using multiple examples, the often-contentious history of copyright law is presented in an approachable and understandable manner.  Tensions between many of the forces that have shaped, and still are shaping, copyright law are discussed, including the tension between creators and consumers of copyrightable materials.  In the end, both forces are shown to be not only important to, but necessary for, the development of U.S. copyright law.  The program closed with a call to action for attendees to speak out on copyright law and to become part of the forces that continue to create change in this discipline.
Breakout Session: New and Notable in Copyright Law. Presented by Nathaniel Edwards, counsel, Lewis, Roca, Rothgerber, and Christie.
Authors: Beck Susan E.
Published: February 2018

U.S. copyright law is a continually changing landscape, especially for educators and librarians. To help update those working in educational institutions, this report showcases new developments in federal case law regarding fair use. The three cases profiled show the courts current tendency to favor fair use. Other topics presented comprise new U.S. Copyright Office procedures for designating DMCA agents and ways to best respond to demand letters sent by photo licensing houses.
MELD Protocol 4 - Lesion Masking v1
Authors: Adler Sophie , Whitaker Kirstie , Wagstyl Konrad
Published: February 2018

The MELD Project is an international collaboration aiming to create open-access, robust and generalisable tools for FCD detection. To this end, we will train a neural network classifier on MRI features from FCD patients from multiple centres worldwide. Protocol 4 provides instructionson how tocreate lesion masks in FreeSurfer using tkmedit.
Side‐effects related to adjuvant CAPOX treatment for colorectal cancer are associated with intermuscular fat area, not with total skeletal muscle or fat, a retrospective observational study
Authors: Plas Rogier L. C. , van Norren Klaske , van Baar Harm , van Aller Carla , de Bakker Maarten , Botros Nadia , Witkamp Renger F. , Haringhuizen Annebeth , Kampman Ellen , Winkels Renate
Published: February 2018

Aims

Chemotherapeutic treatment is regularly accompanied by side‐effects. Hydrophilic chemotherapeutics such as capecitabine and oxaliplatin (CAPOX), often used in colorectal cancer treatment, predominantly accumulate in non‐adipose tissues. Therefore the aim of this paper was to investigate whether body composition and fat infiltration in the muscle (muscle attenuation and intermuscular‐adipose‐tissue [IMAT] content) are associated with chemotherapy‐induced toxicities.

Methods

In this retrospective observational study, we collected data from 115 colorectal cancer patients receiving adjuvant CAPOX chemotherapy between 2006 and 2015. Information on cancer characteristics were obtained from the Netherlands Cancer Registry. Diagnostic CT scans were retrieved to assess cross‐sectional areas of skeletal muscle and adipose tissue at the third lumbar vertebrae. Information on dose‐limiting toxicity [DLT] and relative administered dose (as % of BSA‐based‐planned‐dose) were retrieved from medical charts. Associations between body composition, muscle quality and chemotherapy‐induced toxicities were determined using Cox‐regression and linear‐regression analyses.

Results

We found that DLT incidence was 90% in our cohort: 50% had their dose reduced, 30% their next cycle postponed, 4% a full treatment stop and 6% was hospitalized at their first DLT. Most common were reductions in oxaliplatin dose whilst keeping the capecitabine dose constant. Cox regression analysis indicated no association between body composition or muscle quality and DLT during the first treatment cycle or time to the first DLT. Multiple linear regression showed that higher IMAT‐index and IMAT muscle percentage were associated with a lower relative administered dose of oxaliplatin.

Conclusions

In conclusion; only IMAT, not skeletal or fat area was associated with dose‐limiting toxicities among these CRC patients who received CAPOX treatment.