bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Wafer Handling-Induced Point Defects in 300 mm Silicon Wafer Manufacturing from Edge Geometric Data
Authors: Hu Hao , Lai Xin , Chao Ming Ming , Ullakko Kari
Published: July 2023

For the miniaturization of the structures of semiconductor device fabrication, high uniformity of side-flatness and edge roll-off of 300 mm wafers are required. In this study, the formation of light point defects (LPDs) on silicon (Si) wafer surface due to an edge gripper handling system was investigated. The relationships between the generation of LPDs with respect to flatness, edge profile, and edge roll-off of Si wafers were analyzed. It was found that the variation of tradition facet parameters and near-edge geometry metric, such as edge site front surface-referenced least squares/range (ESFQR), have no impact on the formation of surface LPDs. By contrast, the performance of Z-height double derivative (ZDD), allowed an accurate prediction of formation of surface LPDs. Additionally, for a 300mm silicon wafer, the surface LPDs occurred with frontside ZDD obtained at a radius of 149.2 mm, ranging above -954 nm/mm2 . The surface was LPDs free when ZDD was below -1235 nm/mm2. Surface LPD formation occurred randomly and was not predictable when ZDD ranged from -954 nm/mm2 to -1235 nm/mm2. The result indicates that the LPDs caused by wafer handling is proportional to the performance of ZDD at the edge roll-off area of silicon wafer, this is consistent with the requirement of edge roll-off considering wafer geometry.
Relaxation of the Distorted Lattice of 4H-SiC (0001) Surface by Post-Oxidation Annealing
Authors: Hatmanto Adhi Dwi , Kita Koji
Published: July 2023

Thermal oxidation of 4H-SiC to grow native-oxide SiO2 is always followed by the generation of crystal defects and lattice distortion. We studied the relaxation of this distorted lattice on thermally-oxidized 4H-SiC surface by performing annealing process with several conditions. The surface distortion could be relaxed partially by annealing under argon, nitrogen monoxide, and H2O gases, confirmed by in-plane X-ray diffractometer. This surface relaxation is possibly induced by the release of oxygen-related defects, as confirmed by thermal desorption analysis. The surface distortion caused by thermal oxidation is due to the existence of oxygen in 4H-SiC lattice, while the relaxation is caused by the migration of the oxygen-related defect structure, and emitted from 4H-SiC surface region as CO molecule.
University Librarians’ Perception on the Marketing of Library Services in Sri Lanka: An Attitudinal Survey
Authors: Nishath S. S. , Somaratna H. M. D. S. D.
Published: July 2023

In this Google era, Sri Lankan university librarians are in need to consider a way of “selling” their services to attract new users and retain existing ones. Bridging the gap between the users and the available information resources and services would require a positive perception and attitude of librarians. In this regard, the perception and attitude of Sri Lankan university librarians may influence the marketing of library services. The objective of this study was drawn to analyze the perception and attitude of university librarians in Sri Lanka, towards marketing their services in the light of improving the existing information services. The study involved 130 academic staff members in the libraries of the state universities established under the purview of the University Grants Commission in Sri Lanka. Total population sampling was considered, and self-administrated questionnaires were used for data collection. Data analysis was performed using mean values, frequencies, and Pearson Correlation Coefficient. The results depicted that, Sri Lankan university librarians had a favourable/positive perception and attitude towards marketing library services. This study is significant since administrators with positive attitudes and perceptions towards marketing can develop favourable marketing strategies to promote their products and services among their user community.
Suppression of endoplasmic reticulum stress restores renal microarchitecture in a mouse model of simulated microgravity
Authors: Ramachandran Gopika , Elmoselhi Adel B , Qaisar Rizwan , Kamath Deepika
Published: July 2023

Background:

Hindlimb-unloaded (HU) mice are animal models of simulated microgravity that exhibit pathological changes in several organs; however, relevant findings regarding the kidneys remain elusive. We investigated the possible contribution of protein dysregulation through endoplasmic reticulum (ER) stress to renal pathology in HU mice.

Methods:

We categorized male C57BL/6j mice into ground-based control and HU groups and treated them daily with a placebo or 4-phenylbutyrate (4PBA, an ER stress inhibitor), respectively, for 3 weeks. HU mice showed reduced body weight, whereas kidney weight remained unchanged.

Results:

Treatment with 4PBA increased the kidney weight of HU mice. The histopathological changes in HU mouse kidneys, including the widening of the Bowman’s capsule and increased glomerular area, were reversed through 4PBA treatment, accompanied by a 4PBA-induced reduction in the expression of several ER stress markers. Particularly, we found a reduction in the splicing of the X-box binding protein, indicating reduced ER stress in 4PBA-treated HU mice. Thus, 4PBA may use additional mechanisms to suppress ER stress and prevent renal pathology in HU mice.

Conclusion:

Our findings are the first to suggest that HU causes disruption of renal microarchitecture and that 4PBA may be a potent drug for kidney restoration under HU. Our preliminary findings have translational potential for conditions that mimic HU, such as prolonged bed rest.
Dental pulp revascularization of an open-apex maxillary central incisor in a patient in the fifth decade
Authors: Al Shehadat Saaid , Al Qabbani Ali , Ahmed Hany Mohamed Aly
Published: July 2023

This report presents a case of revascularization of an open-apex maxillary central incisor in a 46-year-old patient using concentrated growth factor (CGF). After disinfection protocol, the apical foramen was mechanically enlarged, and autologous CGF gel was prepared and placed into the root canal to a level close to the cementoenamel junction. The follow-up evaluation confirmed the clinical success of the treatment with the restoration of tooth sensation within 6 months. The previous flat-shaped apex morphology of the tooth changed into a more rounded shape but with no real change in the length of the root or the size of the canal. This case report shows the potential of using the root canal revascularization technique to treat nonvital teeth in elder patients with the advantage of restoration of tooth sensation. The promising role of the CGF in sdental pulp regeneration is also highlighted.
The Factors Related to the Time for Sinus Debridement after Functional Endoscopic Sinus Surgery - A Retrospective Study
Authors: Numano Yuki , Nomura Kazuhiro , Hemmi Tomotaka , Ikeda Ryoukichi , Kakuta Risako , Sugawara Mitsuru
Published: July 2023

Introduction:

Post-operative care after functional endoscopic sinus surgery (FESS) is essential for managing the long-term success of chronic rhinosinusitis. Post-operative sinus debridement promotes proper wound healing, but the procedure can be accompanied by discomfort and pain. Hence, we analysed the clinical factors related to sinus debridement time after FESS.

Materials and Methods:

We evaluated retrospectively the clinical factors affecting the time taken for post-operative sinus debridement on the first visit after the discharge. We reviewed 101 patients who underwent FESS at our hospital by the same surgeon and extracted patient information. The time for post-operative sinus debridement at the first outpatient clinic was measured.

Results:

The days of putting the cotton ball in the operated nostril were negatively associated with sinus debridement time (coefficient – −16.4 ± 5.7 seconds/day, P = 0.005). In contrast, current or history of asthma, amount of bleeding during the surgery, number of opened sinuses by the operation or the number of eosinophils in resected tissues under a microscope at ×400 was not associated.

Discussion:

We recommend the use of a cotton ball in the nostril after FESS because it shortens the sinus debridement time. Placing cotton balls in the nostril helps to maintain a humid wound environment and reduce crusting, leading to easier sinus debridement and better wound healing.
Traumatic intraocular foreign bodies
Authors: Saigol Huma , Iqbal Najam Najam , Akbar Seemab , Rauf Abdul , Chauhan Khurram , Ali Farhan , Alvi Abdul Rehman , Naeem Madeeha , Zeeshan Muhammad
Published: July 2023

Background

Ophthalmic trauma caused by intraocular foreign bodies (IOFBs) can impact visual prognosis by generating direct ocular structural damage. Factors bearing poor visual prognosis are related to size and velocity of IOFB, location in posterior segment with associated retinal detachment or endophthalmitis. Current study is aimed to evaluate size and location of IOFB and associated ocular structural damage.

Methods

In this retrospective study done at single tertiary center, patients injured by IOFBs were analyzed between January, 2010 to January, 2021 for ocular structural damage caused by size, velocity and location of impacted IOFB. All were assessed for corneal or scleral perforation and other structural damage due to IOFB. Location, route of retrieval and size of IOFB was measured.

Results

All 41 eyes were operated for removal of metallic IOFB. Corneal repair was done in 90.2% and scleral repair in 9.8% eyes. Hyphema cleared in 53.6% eyes. Traumatic cataract in 85.4% requiring phacoemulsification, preexisting aphakia (previous surgery) and siderosis was seen in 2.4% eyes. Retinal detachment was present in 14.6% and endophthalmitis in 4.9% eyes. Location of IOFB was on iris and lens in 2.4% each, with 19.5% impacted in retina and 75.6% were isolated in vitreous cavity. Small size IOFB was 58.3%, medium size was 29.3%, large size was 4.9% and very large size was 7.3%. No eye was deformed requiring evisceration of enucleation. Corneal or scleral repair, phacoemulsification, pars plana vitrectomy and intraocular foreign body removal as one stage procedure was done in each case. Intraocular lens implantation was done where sufficient anterior or posterior capsule was present.

Conclusion

Trauma caused by IOFB is commonly seen at workplace in young male laborers. It usually presents as corneal or scleral perforation, traumatic cataract, endophthalmitis and retinal detachment. Level of structural damage to ocular structures is dependent on the size, velocity and location of IOFB impaction. One stage surgical intervention for wound closure and IOFB should be considered for better surgical prognosis.
Long-term outcome of stab incision glaucoma surgery versus trabeculectomy surgery in the management of primary open angle glaucoma
Authors: Abdel Latif Ahmed A. M. , Mousa Amr S. , Awwad Mohammad H. , Ebeid Weam M.
Published: July 2023

Purpose

To assess the long-term outcome of Stab incision glaucoma surgery (SIGS) and compare it with subscleral trabeculectomy (SST) in the management of open-angle glaucoma (OAG).

Methods

Twenty eyes of 20 OAG patients were randomly assigned into group 1: 10 patients underwent SIGS + Mitomycin C (MMC), and group 2: 10 patients underwent SST + MMC. The patients were followed-up over 2 years after surgery. Our outcome measures were: Postoperative intraocular pressure IOP, number of medications used, and postoperative complications.

Results

Twenty-four months postoperatively, the mean IOP was 13.78±2.05 mmHg in the SIGS group compared with preoperative IOP of 26.33±5.1 mmHg (P <0.001, paired t-test), and 14.38±4.56 mmHg in SST group compared with preoperative IOP of 30.13±7.51 mmHg (P <0.001, paired t-test). No significant differences in mean IOP between groups either preoperatively (P=0.15) or along follow-up (P=0.62 at last visit). The mean IOP drop from baseline was 12.56±5.00 mmHg (46.33±10.50%) in SIGS group and 15.75±8.22 mmHg (49.50±17.95%) in SST group (P=0.26). A significant decrease in the number of glaucoma medications was noted in the SIGSS group (P <0.001), in the SST group, the number decreased but was not statistically significant (P =0.120).

Conclusion

SIGS is comparable with SST in achieving long-term significant and maintained IOP reduction over up to 2 years, in addition to decreasing the number of antiglaucoma medications postoperatively. SIGS is recommended for surgical management of primary OAG as it has the advantage of being a faster, easier, less traumatic alternative to conventional SST with fewer complications.
Multiple Myeloma with Myelomatous Pleural Effusion and Mediastinal Plasmacytoma – A Rare Association
Authors: Somson Hasha Thankam , Paul Mobin , George Jalaja Mary , Augustine Jolsana , Venkitakrishnan Rajesh , Cleetus Melcy , Ramachandran Divya
Published: July 2023

Multiple myeloma, a relatively uncommon malignancy accounting for approximately 1%–2% of all cancers, is characterized by neoplastic proliferation of plasma cells producing a monoclonal immunoglobulin. While it mainly affects bone marrow, thoracic manifestations necessitating pulmonologist's attention are not infrequent. Bony involvement of the thoracic cage is the most typical thoracic manifestation of multiple myeloma, whereas less common presentations include pneumonia, pleural effusion, intraparenchymal mass lesions, lymphadenopathy of the mediastinum, reticulonodular shadows, and intrapulmonary calcifications. Myelomatous involvement of pleura with pleural effusions is very uncommon as is extramedullary plasmacytomas involving the mediastinum. We describe the case of an elderly female with multiple myeloma on chemotherapy who developed both these thoracic manifestations simultaneously. Considering her advanced age and poor performance status, family opted for the best supportive care and she succumbed to her primary disease.
Evaluation of USG-guided novel sacral erector spinae block for postoperative analgesia in pediatric patients undergoing hypospadias repair: A randomized controlled trial
Authors: Bansal Teena , Yadav Niharika , Singhal Suresh , Kadian Yogender , Lal Jatin , Jain Mamta
Published: July 2023

Background and Aims:

Erector spinae plane block (ESPB) has been found to be simple, safe, and effective at thoracic and lumbar levels. There is no randomized controlled trial evaluating its effectiveness at sacral level. The present study was conducted to evaluate its effectiveness at sacral level for postoperative analgesia in pediatric patients undergoing hypospadias repair.

Material and Methods:

Forty children of 2–7 years with ASA grade I or II were included. They were randomly allocated to one of the two groups of 20 patients each. After induction of general anesthesia, patients of group I were given ultrasound-guided sacral ESPB with 1 ml/kg of 0.25% bupivacaine, and patients of group II were not given block. Postoperatively, pain was assessed using face, legs, activity, cry, consolability (FLACC) scale at 0 hour, every 15 min up to 1 hour, every half an hour up to 2 hours, 2 hourly up to 12 hours, and at 18th hour and 24th hour postoperatively. At FLACC score ≥4, rescue analgesia was given using 15 mg/kg paracetamol infusion. Primary objective was to compare postoperative analgesic (paracetamol) consumption, and secondary objective was time to first rescue analgesia.

Results:

Mean postoperative paracetamol consumption was 360 ± 156.60 mg in group I and 997.50 ± 310.87 mg in group II (P = 0.001). Time to first rescue analgesia was 906 ± 224.51 min in group I and 205.00 ± 254.92 min in group II (P = 0.001).

Conclusion:

Sacral ESPB has been found to be effective in reducing postoperative analgesic consumption in pediatric patients undergoing hypospadias repair.
A comparative study to evaluate the cervical spine movements during laryngoscopy using Macintosh and Airtraq laryngoscopes
Authors: Kaur Kiranpreet , Raja Rameez , Kumar Prashant , Singh Roop , Vashishth Sumedha , Singh Harshil D. , Bhardwaj Mamta , Singhal Suresh K.
Published: July 2023

Background and Aim:

Intubation with Macintosh requires flexing the lower cervical spine and extending the atlanto-occipital joint to create a “line of sight.” Primary aim of study was to compare the extent of cervical spine movement during laryngoscopy using conventional Macintosh laryngoscope and Airtraq.

Material and Methods:

A total of 25 patients of either sex between the age group of 18 and 60 years, having American Society of Anesthesiologists (ASA) physical status of Grade-I and Grade-II, scheduled for elective surgery under image control requiring general anesthesia and intubation were enrolled. A baseline image of the lateral cervical spine including the first four cervical vertebrae was taken by an image intensifier. After administration of general anesthesia, laryngoscopy was first performed using a Macintosh laryngoscope and a second X-ray image of the lateral cervical spine was taken. The second laryngoscopy using a Airtraq laryngoscope was done and the third image of the lateral cervical spine was taken. Angles between occiput and C1; C1 and C2; C2 and C3; C3 and C4; and occiput and C4 were calculated. Atlanto-occipital distance (AOD) was calculated as the distance between occiput and C1.

Results:

Macintosh showed greater cervical movement as compared with Airtraq but a significant difference in the movement was observed at C2–C3 and C0–C4. Baseline mean AOD was 2.21 ± 1.25 mm, after Macintosh and Airtraq laryngoscopy was found to be 1.13 ± 0.60 and 1.6 ± 0.78 mm, respectively, and was found to be significant (P < 0.05).

Conclusion:

We conclude that Airtraq allows intubation with less movement of the upper cervical spine makes Airtraq preferred equipment for intubation in patients with a potential cervical spine injury.
Concept of stress and strain in pediatric mechanical ventilation
Authors: Shaikh Farhan A. R.
Published: July 2023

Studies have shown that the airway pressures displayed on the screen of the ventilator monitor do not correlate with the actual alveolar distending pressures known as transpulmonary pressure or stress. The change in tidal volume (Vt) on top of the available functional residual capacity (FRC), also known as strain, is an essential factor directly related to stress. Even the correlation of driving pressure (DP) with ventilator-induced lung injury (VILI) needs to be interpreted in the background of what Vt, respiratory compliance (Crs) and at what positive end-expiratory pressure (PEEP) is that DP calculated and at what was the chest wall compliance, and the flow rate at that time. Stress and strain are related to all these factors, either directly or indirectly. The impact of stress and strain should be interpreted in “dynamic terms” over time rather than at one point. Hence, VILI is minimized by optimizing the Strain (using appropriate PEEP and Vt against available FRC) and stress (transpulmonary inspiratory and expiratory pressures), applied at an optimal respiratory rate and flow. In the pediatric age group, pulmonary mechanics also change as age changes. Moreover, children respond differently to lung injury than adults, adding another layer of complexity to the concept of stress and strain in the pediatric population. Despite this, most knowledge about stress and strain has come from studies in the adult population. Therefore, more extensive studies focussing on pediatric age groups are needed to improve our understanding of stress and strain in pediatric ventilated patients.
Personalized lung-protective ventilation in children – Is it possible?
Authors: Venkataraman Shekhar T.
Published: July 2023

Mechanical ventilation, while life-saving, can be associated with risks of exacerbating existing lung injury or causing new injury. An understanding of how mechanical ventilation can injure the lung and other systems is important to develop an optimal ventilatory approach. Over the past 70 years, different mechanisms that can cause lung injury have been described with putative suggestions for lung protection. Which mechanisms are operating in a particular patient is difficult to ascertain at the bedside. Guidelines have been formulated for both adults and children for the management of patients on mechanical ventilation with acute respiratory distress syndrome. Lung protection is the main objective of these guidelines. Lung disease is not homogeneous within the lung, and between patients with the same diagnosis. Response to ventilatory parameters also differs based on the distribution of injured and uninjured lungs, being beneficial in some but harmful in others. The impact of mechanical ventilation on the cardiovascular system and other systems is also variable. It is important to understand that these guidelines are one-size-fits-all therapeutic suggestions. While guidelines are useful, it is important to personalize mechanical ventilation based on the patient’s lung mechanics and their response to adjustments of the ventilatory parameters. This chapter will review the current knowledge of the factors that contribute to injury to the lungs from mechanical ventilation. At the end of the review, I have formulated a personalized approach to lung protection during invasive mechanical ventilation for patients with parenchymal lung disease – a consensus of one.
The Relationship of Desaturation, Oxidative Stress, Comorbid Diseases, and Conditions in Obstructive Sleep Apnea Syndrome
Authors: Karakaptan Yasemin , Bulut Onur , Dibek Dilara Mermi , Öztura İbrahim , Baklan Barış
Published: July 2023

Introduction:

Obstructive Sleep Apnea Syndrome (OSAS) is associated with clinical pictures ranging from morning headache to vascular diseases and sudden death. It negatively affects the quality of life by causing deterioration in sleep quality, a decrease in work and academic performance caused by excessive daytime sleepiness (EDS), social restriction, and an increase in work/traffic accidents and depression. OSAS may cause comorbidities and conditions by desaturation. We aimed to investigate the effect of desaturation and cellular level hypoxia in patients with OSAS on comorbid diseases and conditions and emphasize their importance.

Subjects and Methods:

The study design was cross-sectional. A total of 100 patients (73 males and 27 females) aged 18–70 years were included in the study. Demographic data, presence of comorbidities (diabetes mellitus [DM], hypertension [HT], coronary artery disease), and symptoms related to OSAS (nocturia, enuresis, and morning headache) were questioned. In addition, the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Scale were administered, the results of polysomnographic data were evaluated, and lactic acid levels were measured as an indicator of hypoxia at the cell level.

Results:

The minimum oxyhemoglobin saturation level was found to be associated with body mass index (BMI) (P = 0.004), HT (P = 0.005), ESS scores (P = 0.022), sleep apnea severity, depression scale (P = 0.012), position-related sleep apnea (P = 0.005), and lactic acid levels (P = 0.002). No correlation was found between sex, DM, CAD, morning headache, nocturia and enuresis, PSQI, and repaid eye movement -related sleep apnea.

Conclusion:

Although hypoxemia was shown to be associated with BMI, HT, EDS, depression, sleep apnea severity, positional apnea, and lactic acid in our study, sufficient evidence could not be obtained to consider the minimum oxyhemoglobin saturation level in the OSAS treatment plan. In the clinical evaluation of OSAS, apnea-hypopnea index and these parameters should be taken into account by physicians in the prediction of comorbidities and risks.
Задачи Коши, связанные с интегрируемыми матричными иерархиями
Authors: Helminck Gerard F
Published: July 2023

Обсуждается разрешимость двух задач Коши для матричных псевдодифференциальных операторов. Первая из них связана с множеством матричных псевдодифференциальных операторов отрицательного порядка, ярким примером которого является множество строго интегральных частей произведений решения $(L,\{U_\alpha\})$ $\mathbf h[\partial]$-иерархии, где $\mathbf h$ - максимальная коммутативная подалгебра в $gl_n(\mathbb{C})$. Показано, что эта задача Коши имеет решение, если используемое для нее окружение удовлетворяет условию полной совместности. Вторая задача Коши немного более общая, она связана с набором матричных псевдодифференциальных операторов порядка меньше или равного нулю. Ключевым примером здесь является совокупность интегральных частей различных произведений решения $\{V_\alpha\}$ строгой $\mathbf h[\partial]$-иерархии. Эта задача Коши разрешима, если выполняются два свойства: полная совместность и коши-разрешимость в размерности $n$. Показано, что оба условия выполняются в окружении, основанном на алгебре формальных степенных рядов.
INDIRECT PREDICTION OF ROCK ELASTICITY AND COMPRESSIBILITY STRENGTH USING WELL LOGDATA AT SELECTED SITES WITHIN RUMAILA OILFIELD, SOUTHERN IRAQ
Authors: Al-Malikee Hussein S. , Al-Najim Fahad M.
Published: July 2023

Wellbore failure is the main reason for about 14% of drilling non-productive time (NPT) for new wells in Rumaila oilfield; these breakouts were observed in Shale and weak shaly Sandstones across the geologic column. The rock mechanical properties which include elasticity (Young’s modulus, Bulk modulus, Shear modulus and Poisson’s ratio) and unconfined compressive strength (UCS) are broadly used in well design and wellbore stability by means of predicting the required drilling parameters that can help to reduce wellbore failure. In this study, an indirect estimation of the rock mechanical properties was carried out using gamma ray, density, sonic (compressional and shear), and Neutron logs. The log data were gathered from four wells (R-518, R-527, Ru-382 and Ru-385) in the Rumaila oilfield, that data cover the geological column from Saadi to Zubair formations. Later, the indirect rock mechanical properties prediction results were compared with the direct measurements that been measured by triaxial mechanical laboratory tests for well R-530 and uniaxial tests on wells R-019, R-062 and R-530 in Rumaila oilfield. The results of indirect estimation of rock mechanical properties showed similarity to direct measurements which make it reliable and can be used for wellbore stability analysis and may contribute effectively in building the geomechanical model.
NEW MIDDLE MIOCENE OSTRACODES (CRUSTACEA) FROM KURDISTAN REGION, NORTHEASTERN IRAQ
Authors: Hawram Omran A.M. , Ali Hazhar J.
Published: July 2023

The present paper is focused on new Ostracods species obtained from Fatha Formation (Middle Miocene) in Darbaikhan area, Sulaimani Governorate, Kurdistan province North Eastern of Iraq. Forty-eight Ostracode species belonging to thirty-one genera were described, including eighteen species previously described, twenty-six new species left under open nomenclature because of lack of specimens and/or poor state of preservation.
Information Technology Utilization in The Disclosure of Drug Crimes by West Jakarta Metro Police
Authors: Pradana Satria Arya , Suryadi Suryadi , Luthan Ahwil
Published: July 2023

The discussion in this study is the continued increase of circulation and abuse of drugs in West Jakarta Police jurisdiction requires Police to make breakthrough efforts by utilizing Information Technology, namely by tapping the perpetrators' cell phones. Drug cases and these efforts directly impact the performance of the investigators and the number of drug cases they have successfully handled. This paper will explain: 1) Illicit trafficking and drug abuse in the Legal area of ??the West Jakarta Police has reached an alarming level because international and local trafficking syndicates prefer Jakarta as their circulation area. Data evidence this for the period 2019 and 2021 the total number of perpetrators who have been arrested will reach 1014 people; 2) Disclosure of drug cases conducted by West Jakarta Police is carried out using three methods, namely conventional methods, utilizing information technology methods, and combination methods; 3) The impact of the use of information technology in disclosing drug cases by West Jakarta Police: (a) Improving the performance of investigators' personnel; (b) Disclosure of drug cases can be optimal; (c) Drug networks will be exposed to top-level dealers.
Tourism Object Valuation Determined Based on Environmental Services Using Travel Cost Method at Tegal City Alam Indah Beach
Authors: Triono Doni , Mediantoro Adro
Published: July 2023

Alam Indah Beach is located in a strategic urban coastal area so it has a very high potential to be used as a tourist attraction. This study aims to determine descriptively the analysis of the socio-economic characteristics of visitors and to know quantitatively the economic value of the Alam Indah Beach Tourism Object and the relationship between several variables that affect the number of visits from the object. This research is a quantitative study with primary and secondary data collection through library research and field studies using interviews, observation, and questionnaires. The results of the study reveal that the total cost variable has the most significant influence on the number of tourist visits, reaching 80.27% and resulting in a total consumer surplus of IDR. 130.355.024, willingness to pay of IDR. 136,497, and an economic valuation of IDR. 35,508,314,810. Major economic benefits from tourism activities in Alam Indah beach brings socio economic improvement of the local community. The result of economic value of beach tourism object could be a reference for managers and local governments to balance between beach as a preservation with additional income for local governments and societies.
Web-Based Electronic Goods Sales Application Design
Authors: Farizki Rafi , Mualiman Lutfi , Wicaksono Freddy , De Jesus Fhrizz S. , Autonomous Meritorious , Cuong Vo Hung
Published: July 2023

The development of technology, especially internet-based technology, is increasing, including sales information system technology or so-called web online stores that can be used to purchase products simply by logging into the web, selecting the preferred goods and paying using a transfer system, the goods will be delivered to the address which is aimed. In Indonesia, the development of sales information systems is very reasonable and will continue to increase rapidly with the spread of the internet to all corners of the region. The purpose of this research is to know that this sales application system can already be used online. The method used is to use system design analysis. The results showed that in making these electronic goods sales application using the PHP programming language with MYSQL Database. The application for selling electronic goods is also known to have three important aspects, namely: login menu, admin dashboard, and payment page.
HİPEREMEZİS GRAVİDARUMLU GEBELERDE DEPRESİF SEMPTOMLAR VE KİŞİLİK ÖZELLİKLERİNİN BULANTI KUSMA ŞİDDETİ İLE İLİŞKİSİ
Authors: NACAR Gülçin , DERMAN Gamze , GÜZEL İNAL Ceylan
Published: July 2023

Amaç: Araştırmanın amacı, hiperemezis gravidarumlu gebelerde depresif semptomlar ve kişilik özelliklerinin bulantı kusma şiddeti ile ilişkisinin belirlenmesidir.

Yöntem: Tanımlayıcı ve ilişki arayıcı tipte olan araştırma 100 hiperemezis gravidarumlu gebe ile yürütülmüştür. Araştırma İç Anadolu Bölgesinde bulunan bir ildeki bir kamu hastanesinin gebe polikliniğinde yapılmıştır. Araştırma verileri, Katılımcı Tanıtım Formu, Gebeliğe Özgü Bulantı Kusma Değerlendirme Skalası, Cervantes Kişilik Ölçeği ve Edinburgh Postpartum Depresyon Ölçeği kullanılarak elde edilmiştir. Araştırma verilerinin değerlendirilmesinde tanımlayıcı istatistikler, Ki Kare testi, ANOVA testi kullanılmıştır.

Bulgular: Araştırmada gebelerin %60’ ının bulantı kusma şiddetinin orta düzeyde olduğu saptanmıştır. Bulantı kusmanın gebelerin %87’ sinin günlük aktivitesini etkilediği, %90’ nın fiziksel aktivitesini etkilediği görülmüştür. Bulantı kusması şiddetli olan gebelerin daha fazla depresif semptom gösterdiği saptanmıştır (p=0.036). Kişilik özellikleri ile bulantı kusma şiddeti arasında ise anlamlı bir ilişki bulunmamıştır (p>0.05).

Sonuçlar ve Öneriler: Araştırmada şiddetli bulantı kusması olan gebelerin daha fazla depresif semptom gösterdiği bulunmuştur. Hiperemezis gravidarumlu gebeler ile çalışan sağlık profesyonellerinin hastalarını depresif semptomlar yönünden değerlendirmesi önerilmektedir.
The Role of Information Technology in Improving the Efficiency and Productivity of Human Resources in the Workplace
Authors: Diawati Prety , Gadzali Silvy Sondari , Abd Aziz Mohd Kasturi Nor , Almaududi Ausat Abu Muna , Suherlan Suherlan
Published: July 2023

The ubiquity of information technology in contemporary society has rendered it an indispensable component across a wide range of domains. The utilization of information technology has had a noteworthy influence on enhancing efficiency and productivity in diverse domains, encompassing the professional milieu. The Human Resources function is a crucial element within an organization, playing a significant role in driving the success and expansion of the company. The objective of this investigation is to scrutinize the function of IT in enhancing HR efficacy and output within the workplace. It is crucial to comprehend the ramifications of IT employment within an organizational framework. The primary emphasis of this investigation is qualitative in nature. The process of data collection involves meticulous observation and recording of data, followed by the application of analytical methods such as data reduction, visualisation, and inference to derive meaningful insights. The research has deduced that in the constantly changing digital era, the significance of information technology in enhancing the effectiveness and output of human resources in the work environment is pivotal. IT facilitates the automation of mundane tasks, enhances collaboration, provides expedient access to information, enables effective training, supports intelligent data analysis, promotes efficient performance management, allows for work flexibility, and ensures information security.
Bibliometric Investigation of Academic Studies on “Tax Compliance” Published between 1983-2021
Authors: TEKİN Ahmet , SÖKMEN GÜRÇAM Özlem
Published: July 2023

Tax Compliance refers to the timely and lawful fulfillment of tax obligations by taxpayers to ensure full tax payment. Understanding the factors influencing taxpayers' decisions to comply with tax laws is a central topic in the literature. This article presents a bibliometric analysis of academic research on Tax Compliance, covering studies published between 1983 and 2021 and indexed in the Web of Science (WoS) database. The analysis aims to provide insights and guidance for future research in this area. A total of 585 studies on Tax Compliance were identified in the WoS database, with the majority being articles primarily written in English. The United States, England, Australia, and Austria emerged as the most productive countries in terms of Tax Compliance publications. Furthermore, a notable trend is the growing number of multidisciplinary studies conducted by authors from diverse countries. To enhance future research endeavors, this study recommends exploring multiple databases and broadening search queries to include additional fields. By doing so, researchers can gain a more comprehensive understanding of Tax Compliance and its various influencing factors. This bibliometric mapping of academic studies on Tax Compliance provides a foundation for advancing knowledge and fostering informed investigations in the domain of taxation and compliance behavior.
EFEK PEMBERIAN EKSTRAK KAYU CENDANA (Santalum album L.) TERHADAP KADAR C-REACTIVE PROTEIN (CRP) TIKUS PUTIH (Rattus norvegicus) MODEL SEPSIS Methicillin-Resistant Staphylococcus aureus (MRSA)
Authors: Hudriyah Anis , Hartini Supri , Sukarya I Gede Andika
Published: July 2023

Sepsis merupakan kondisi klinis yang akut dan berbahaya yang disebabkan oleh serangan mikroorganisme (bakteri). Dalam penanganan sepsis membutuhkan biomarker, salah satunya adalah C-Reactive Protein (CRP) yang dapat meningkat ketika terjadinya infeksi. Ekstrak kayu cendana mengandung senyawa antibakteri dan antiinflamasi yang dapat mendenaturasikan protein pada bakteri. Tujuan dilakukan penelitian ini untuk mengetahui efek atau pengaruh ekstrak kayu cendana (Santalum album L.) terhadap kadar CRP tikus putih model sepsis Methicillin-Resistant Staphylococcus aureus (MRSA). Jenis penelitian ini menggunakan eksperimen murni. Sampel penelitian ini menggunakan tikus putih sebanyak 27 ekor yang dibagi kedalam 3 kelompok, yaitu kelompok kontrol, model sepsis MRSA, dan model sepsis MRSA yang diberi ekstrak kayu cendana. Penelitian ini dilakukan di Laboratorium Imunologi, Teknologi Laboratorium Medis, Poltekkes Kemenkes Kaltim. Analisis data dilakukan secara univariat dan bivariat untuk mengukur efek atau pengaruh pemberian ekstrak kayu cendana terhadap kadar CRP tikus putih model sepsis MRSA. Hasil penelitian didapatkan dan dianalisis dengan uji statistik Mann-Whitney menunjukkan adanya pengaruh yang bermakna (penurunan) pada kadar CRP tikus putih model sepsis yang diberi ekstrak kayu cendana dengan nilai p value 0,040. Sehingga dapat disimpulkan bahwa ada pengaruh pemberian ekstrak kayu cendana terhadap kadar CRP pada tikus putih model sepsis MRSA.

Kata Kunci: Sepsis, Kayu Cendana, C-Reactive Protein (CRP)
Unpacking the Factors of Overweight/Obesity in Type 2 Diabetes: What You Need to Know: Review Article
Authors: Abdel-latif Megahed Fatma Ibrahim
Published: July 2023

The rising prevalence of overweight and obesity among type 2 diabetic patients has become a major concern for healthcare professionals. Obesity and overweight are significant risk factors for the development of type 2 diabetes. In fact, it is estimated that over 90% of individuals with type 2 diabetes are either overweight or obese. Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, leading the World Health Organization to label them as pandemics of the 21st century. In this article, we will explore the different factors that contribute to overweight/obesity among individuals with type 2 diabetes. Genetics and family history play a crucial role in the development of obesity. Lifestyle factors, such as poor dietary habits, physical inactivity, sedentary behavior and poor sleep quality and duration are also a significant risk factor for obesity.
A REVIEW ON BILOSOMES: ADVANCED DRUG DELIVERY SYSTEM
Authors: Ansari Irshad , Shakeel Kashif
Published: July 2023

Bilosomes are bilayer vesicles that transport lipids incorporating non-ionic surfactants and bile salts. The current review was based on the properties, materials used in the preparation, various methods of formulation, characterization parameters and various pharmaceutical and clinical applications. They are spherical, uni-lamellar, and 5-200 nm-sized and vesicles with many membranes. Under normal conditions, bile acids exist as ionised bile salts after being synthesised in the liver and stored in the gall bladder. They have a steroid nucleus that is both hydrophilic. Materials used in bilosomes comprise of lipids, non-ionic surfactants and bile salts. Bilosomes are prepared by various methods including Reverse phase evaporation, Thin Film Hydration and Hot Homogenization. Bilosomes are characterized in terms of particle size, polydispersity index (PDI), zeta potential, ultracentrifugation, entrapment efficiency, in-vitro drug release and stability. Bilosomes have wide range of applications i.e., oral drug candidates, improved hypoglycaemic activity, oral immunization against tetanus, in ocular and transdermal drug delivery. For immunologists, the formulation of a reliable oral delivery mechanism for mucosal vaccines presents a considerable problem. In this regard, bilosomes and other lipid-based delivery methods have been investigated and developed for oral immunisation. Due to the tremendous potential of bilosomes, which include biocompatibility, stability, and specificity as carriers for targeted administration in immunisation. Currently, it is crucial for clinical researchers to use their knowledge of bilosomes for safe and effective trials in human patients and to identify the precise immunological mechanism triggered by bilosome oral administration.
A GOVERNANÇA CORPORATIVA EM EMPRESAS PÚBLICAS: UM ESTUDO TEÓRICO
Authors: Amado Tristão Pâmela , Zamberlan Fuchs Leandro
Published: July 2023

A governança corporativa constitui-se como um conjunto de normas e princípios adotados na gestão de empresas com foco na redução do problema que envolve o agente-principal. Embora sua adoção tenha sido amplamente debatida no que tange às práticas adotadas no setor privado, o tema tem, nos últimos anos, ganhado destaque quanto às práticas adotadas em empresas estatais. Nesse contexto, o presente estudo objetivou identificar os aspectos que devem ser considerados para tornar possível a implementação da governança corporativa em empresas públicas. Para tanto, foi realizado um estudo bibliográfico de natureza qualitativa e abordagem descritiva, por meio do levantamento da produção científica nacional e internacional acerca do tema, permitindo a discussão deste. É possível argumentar que a adoção das práticas da boa governança em empresas públicas requer adaptações, haja visto ser a população, de forma geral, a grande beneficiária de práticas mais transparentes, sustentáveis e de maior equidade, o que traz novos riscos e desafios específicos ao Estado. Contudo, órgãos como a Organização para Cooperação e Desenvolvimento Econômico (OCDE) têm focado em esforços na determinação de diretrizes e princípios para a adoção adequada do setor público.
O PROFISSIONAL FARMACÊUTICO PROMOVENDO O CUIDADO E PREVENÇÃO DO DIABETES MELITOS II: EDUCAÇÃO FARMACÊUTICA
Authors: Nonato Macedo Costa Cleber
Published: July 2023

O projeto vem desenvolver a ideia de que a adesão à medicação é parte do tratamento, mas reconhecer a necessidade de mudança de hábitos e uma reeducação fará toda a diferença no processo. Trabalhar um olhar mais empático, buscando cada  vez mais a humanização em nossos procedimentos com o cuidado e a prevenção faz  parte do complemento que vai além do tratamento medicamentoso. Nosso projeto trata de um estudo metodológico, que envolve uma investigação dos métodos  pautada no desenvolvimento de ferramentas para análise de alcance e de impacto dos resultados. Esse tipo de metodologia de pesquisa é frequentemente usado para o desenvolvimento de tecnologias criativo-educacionais (TCE) podendo ser utilizada dentro do sistema de ensino, na comunidade, nas famílias, com o indivíduo e como forma de educação permanente, dentro das classes profissionais. A partir das fragilidades no cuidado identificadas nos usuários com diabetes tipo II e com base na literatura, iniciou-se a construção do Folder a validação foi realizada por um grupo de 20 profissionais da área da saúde sendo formado por 10 (50%) enfermeiros, 3 (15%) técnicos de enfermagem, 5 (25%) médicos, 2 (10%) Nutricionista sendo este último como consultores da parte nutricional do estudo, Contudo, um nutricionista e 4 enfermeiros não retornaram o questionário, totalizando assim 20 profissionais da saúde que validaram o material. O perfil de titulação destes profissionais indicou que dez (50%) possuíam graduação, três (15%) nível técnico e dois (10%) mestrado e cinco (25%) doutorado, com a produção de tabelas para melhor explanação dos resultados.
Method for calculating the integrated biological age of a human
Authors: Pisaruk Anatoly , Shatilo Valeri , Grygorieva Natalia , Chyzhova Valentina , Antoniuk-Shcheglova Ivanna , Koshel Natalia , Naskalova Svitlana , Bondarenko Olena , Mekhova Ludmila , Dubetska Halina , Pisaruk Ludmila , Shatylo Vladislav
Published: July 2023

Abstract. Integral biological age (BA) encompasses a holistic assessment of an individual's overall physiological state, taking into account various biological markers that may contribute to the ageing process. This article presents a novel method for determining the integral biological age, a comprehensive measure that considers multiple biological markers and factors to assess an individual's ageing process. We will delve into the various components and biomarkers utilized in our method, including cardiorespiratory and musculoskeletal systems functionality, and other molecular markers associated with ageing. By combining these diverse indicators, we create an integrated framework that provides a holistic view of an individual's ageing trajectory.
The study included 124 practically healthy people aged from 20 to 90 years, who were examined at the «D.F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine». People with pathologies of the cardiovascular, respiratory, endocrine and central nervous systems, chronic liver and kidney diseases, and pathologies of the hematopoietic system were excluded from the analysis.
We recorded 74 indicators characterizing different body systems: hearing, cardiovascular, respiratory, and musculoskeletal systems, as well as autonomic regulation and metabolism. To build a model of integral BA, indicators of each of the systems that have the highest correlation with age were selected. An important selection criterion was the low cross-correlation of these indicators. The use of step-by-step multiple regression made it possible to select the most informative indicators and obtain an equation that relates the age of the subjects with a number of indicators of the main body systems.
The resulting calculation formula includes 11 indicators characterizing different body systems. The coefficient of determination of the model R2 was 0.738, indicating the high accuracy of the created model. The mean absolute error of age calculation was 5.34±3.99 years. After correcting the systematic error of the regression equation, the average absolute error in calculating the age was 4.72±3.25 years. The rate of ageing was estimated as the difference between BA and CA. If this difference exceeds the value of the model error, a conclusion can be made about accelerated ageing.
Thus, the method for assessing the rate of ageing developed by us has high accuracy and can be used to assess the risk of developing age-dependent pathology. The implementation of the proposed method will allow not only to identify people with the risk of developing pathology but also to assess the effectiveness of treatment, prophylactic and rehabilitation measures.

Keywords: integral biological age; method calculation; cardiovascular; respiratory; musculoskeletal systems; metabolism; human
A novel approach of unsupervised feature selection using iterative shrinking and expansion algorithm
Authors: Gowda V. Dankan , Sharma Avinash , Kumaraswamy S. , Sarma Parismita , Hussain Naziya , Dixit Santosh Kumar , Gupta Anand Kumar
Published: July 2023

An major constraint in the realm of feature selection is that users choose the ideal number of characteristics that must be picked. In this article, an effort is made to automate the process of determining a suitable value for the appropriate the quantity of characteristics that must be chosen for better recognition tasks. To estimate the ideal amount of features that should be maintained for properly describing the data, we use the dense subgraph discovery approach for this goal. Notably, the existing methods uses a similar kind of approach called the dense subgraph finding. But the earlier approach obtains a single dense subgraph, while the task of dense subgraphs finding obtains a number of dense subgraphs that are important for learning the internal structure of any network. Thus, dense subgraphs finding is likely to be adopted as a natural choice for realizing the complex relations among the nodes of massive real-life networks, such as biological networks, social networks.