bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensory and Volatile Compounds Characteristics of the Sauce in Bean Paste Fish Treated with Ultra-High-Pressure and Representative Thermal Sterilization
Authors: Zhao Jie , Zhang Yimao , Chen Yu , Zheng Yuhui , Peng Changbo , Lin Hongbin , Che Zhenming , Ding Wenwu
Published: December 2022

This study investigated the differences between three sterilized samples to reveal the unique aroma characteristics of the sauce in bean paste fish by multiple analysis methodologies. Samples were subjected to pasteurized (PS), high-temperature sterilization (HTS), and ultra-high-pressure treatment (UHP) tests. The UHP had a higher sensory evaluation and could better maintain the original flavor of the sample. A total of 92, 83, 85, and 76 volatile compounds were detected via comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) techniques in the control (CT), PS, HTS, and UHP groups, respectively. According to the analysis of gas chromatograph-olfactometry and odor activity value, 7 compounds were considered to have an aromatic influence on the sauces, in which four compounds (1,8-Cineole, Linalool, Hexanal, and Dimethyl trisulfide) exhibited a positive contribution to the aroma of the sauces. PLS-DA results showed that the UHP group positively correlated with volatiles (Isoamylol and 1-Octen-3-ol), color, and gloss. In general, the UHP treatment could retain the original state and flavor of the sauce, showing a high similarity to the control group. The HTS significantly altered the flavor and status of the samples.
Preparation of Gum Arabic–Maltose–Pea Protein Isolate Complexes for 1−Octacosanol Microcapsule: Improved Storage Stability, Sustained Release in the Gastrointestinal Tract, and Its Effect on the Lipid Metabolism of High−Fat−Diet−Induced Obesity Mice
Authors: Ding Yin-Yi , Pan Yuxiang , Zhang Wanyue , Sheng Yijing , Cao Yanyun , Gu Zhenyu , Shen Qing , Wang Qingcheng , Chen Xi
Published: December 2022

1-Octacosanol (Octa) is a natural compound with several beneficial properties. However, its poor water solubility and metabolism in the digestive tract reduce its efficacy. The Octa-GA-Malt-PPI microcapsule was prepared as follows: gum Arabic (GA):maltose (Malt):pea protein isolate (PPI) = 2:1:2; core:shell = 1:7.5; emulsification temperature 70 °C; pH 9.0. An in vitro simulated gastrointestinal tract was used to analyze the digestion behavior. C57BL/6 mice were selected to establish an obesity model induced by a high-fat diet (HFD) to evaluate the effect of Octa monomer and the microcapsule. The diffusivity in water and storage stability of Octa improved after encapsulation. The microcapsule was ascribed to electrostatic interactions, hydrogen bonding, and hydrophobic interactions. The sustained release of Octa from the microcapsule was observed in a simulated gastrointestinal tract. Compared with Octa monomer, the microcapsule was more effective in alleviating the symptoms of weight gain, hypertension, and hyperlipidemia induced by HFD in mice. In conclusion, the construction of microcapsule structure can improve the dispersibility and stability of Octa in water, achieve sustained release of Octa in the gastrointestinal tract, and improve its efficiency in alleviating the effects of HFD on the body.
Effect of Emulsion Particle Size on the Encapsulation Behavior and Oxidative Stability of Spray Microencapsulated Sweet Orange Oil (Citrus aurantium var. dulcis)
Authors: Peng Qun , Meng Ziyi , Luo Ziyang , Duan Hanying , Ramaswamy Hosahalli S. , Wang Chao
Published: December 2022

Three different feed emulsions of different particle sizes were mixed with a modified starch and maltodextrin and spray dried to make a large (LP), small (SP), and nano-size encapsulated powder (NP), respectively. Emulsion size, oil content, loading capacity (LC), encapsulation efficiency (EE), water content, aw, scanning electron microscopy (SEM), glass transition temperature (Tg), as well as d-limonene release characteristic and limonene oxide formation rate during 37 °C and various aw storage were determined. With the increase of the feed emulsion size, the reconstituted emulsion size of the LP tended to increase and change to a bimodal distribution. The surface oil content increased with the increasing size of the reconstituted emulsion, and the opposite was true for EE. The smaller the reconstituted emulsion size, the higher Tg during a low aw condition. The Tg of the LP, SP and NP were 62, 88, and 100 °C, respectively, and NP > SP > LP. The release and the oxidative rate of d-limonene was the lowest for the NP and then increased for the SP and LP. The release and oxidative rates increased with the elevation of aw and peaked at 0.33. The powder surface morphological structure was intact, the spray-dried powder was more stable, and microstructure changed from a glass state to a rubbery state during storage.
Brassinin Abundant in Brassicaceae Suppresses Melanogenesis through Dual Mechanisms of Tyrosinase Inhibition
Authors: Lee Min-Kyeong , Ryu Heeyeon , Jeong Hyeon Hak , Lee Bonggi
Published: December 2022

Brassinin is a phytoalexin abundant in plants, especially in cabbage, and has been reported to act as an anti-cancer and anti-inflammatory agent. However, limited studies are available to elucidate the functionalities of brassinin. Here, we tested the effects of brassinin on melanogenesis using cell-free and cell-based biochemical analysis and docking simulation. Cell-free experiments exhibited that brassinin has antioxidant and anti-tyrosinase activities. When applied to B16F10 cells stimulated with a melanogenesis inducer α-MSH, brassinin pretreatment significantly reduced melanin accumulation and cellular tyrosinase activity. Docking simulation indicates that the docking score of brassinin to the binding pocket of tyrosinase is better than that of kojic acid or arbutin, anti-melanogenic positive controls, indicating that brassinin inhibits melanogenesis at least partially by binding to and inactivating tyrosinase. In addition, qPCR results showed that brassinin reduced tyrosinase mRNA levels. Together, these results suggest that brassinin exerts anti-melanogenesis effects by inhibiting both the activity and mRNA expression levels of tyrosinase. Therefore, our study showed that brassinin has the potential to be used in pharmaceutical or cosmetic products for depigmentation.
Algae as Nutritional and Functional Food Sources
Authors: Boukid Fatma , Castellari Massimo
Published: December 2022

Algae are a large and diverse group of autotrophic eukaryotic and photosynthetic aquatic organisms [...]
Preparation of Gelatin from Broiler Chicken Stomach Collagen
Authors: Prokopová Aneta , Gál Robert , Mokrejš Pavel , Pavlačková Jana
Published: December 2022

With the increasing consumption of poultry meat around the world, the use of chicken stomachs as a source of collagen is being offered. The objective of this study was to extract gelatin from the stomachs of broiler chickens and to estimate their gel strength, ash content, viscosity, gelling point, melting point, clarity and digestibility. An innovative biotechnological method based on the conditioning of collagen with a microbial endoproteinase (Protamex®) and hot-water extraction was used to control the chemical and thermal denaturation process of collagen to prepare gelatin. The experiments were planned using a Taguchi design, 2 factors at 3 levels; factor A for the amount of proteolytic enzyme (0.10, 0.15 and 0.20%) and factor B for the extraction temperature (55.0, 62.5 and 70.0 °C). Data were statistically processed and analyzed at a significance level of 95%. The gelatin yield averaged 65 ± 8%; the gel strength ranged from 25 ± 1 to 439 ± 6 Bloom, the viscosity from 1.0 ± 0.4 to 3.40 ± 0.03 mPa·s, gelling point from 14.0 ± 2.0 to 22.0 ± 2.0 °C, melting point from 28.0 ± 1.0 to 37.0 ± 1.0 °C. The digestibility of gelatin was 100.0% in all samples; the ash content was very low (0.44 ± 0.02–0.81 ± 0.02%). The optimal conditions for the enzymatic treatment of collagen from chicken stomachs were achieved at a higher temperature (70.0 °C) and a lower amount of enzyme (0.10–0.15%). Conditioning chicken collagen with a microbial endoproteinase is an economically and environmentally friendly processing method, an alternative to the usual acid- or alkaline-based treatment that is used industrially. The extracted products can be used for food and pharmaceutical applications.
The Sustainability of Sweet Potato Residues from Starch Processing By-Products: Preparation with Lacticaseibacillus rhamnosus and Pediococcus pentosaceus, Characterization, and Application
Authors: Zhu Lili , Sun Hongnan , Ma Mengmei , Mu Taihua , Zhao Guohua , Lwin Moe Moe
Published: December 2022

The effects of Lacticaseibacillus rhamnosus and Pediococcus pentosaceus on the nutritional–functional composition, structure, in vitro saliva–gastrointestinal digestion, and colonic fermentation behaviors of fermented sweet potato residues (FSPR) were investigated. The FSPR was obtained under the condition of a solid-to-liquid ratio of 1/10, inoculation quantity of 1.5%, mixed bacteria ratio 1:1, fermentation time of 48 h, and fermentation temperature of 37 °C. The FSPR showed higher contents of soluble dietary fiber (15.02 g/100 g), total polyphenols content (95.74 mg/100 g), lactic acid (58.01 mg/g), acetic acid (1.66 mg/g), volatile acids (34.26%), and antioxidant activities. As exhibited by FTIR and SEM, the higher peak intensity at 1741 cm−1 and looser structure were observed in FSPR. Further, the FSPR group at colonic fermentation time of 48 h showed higher content of acetic acid (1366.88 µg/mL), propionic acid (40.98 µg/mL), and butyric acid (22.71 µg/mL), which were the metabolites produced by gut microbiota using dietary fiber. Meanwhile, the abundance of Bifidobacterium and Lacticaseibacillus in the FSPR group was also improved. These results indicated that FSPR potentially developed functional foods that contributed to colonic health.
Development of an Encapsulation Method for Trapping the Active Materials from Sour Cherry Biowaste in Alginate Microcapsules
Authors: Toprakçı İrem , Torun Mehmet , Şahin Selin
Published: December 2022

This study aims to contribute to those valorization approaches for the recovery process of high-value-added substances in environmentally friendly ways. In this study, one of the most consumed juice products was selected for providing waste byproducts (peel). Sour cherry peels were subjected to automatic solvent extraction using a GRAS solvent (aqueous 80% ethanol, v/v). Then, encapsulation for the preservation of the related extract was performed by ionic gelation in alginate beads. The process conditions (gelling medium concentration, wall material concentration, and hardening time) were optimized by a Box–Behnken design (statistical experimental design approach). An almost 80% encapsulation efficiency was achieved under the proposed method (7.8% CaCI2, 1.3% alginate, and 26 min). The inhibition effect of the produced capsules against DPPH (2,2-diphenyl-1-picrylhydrazil) radicals also shows that the current products might represent potential alternative natural antioxidants for food formulations. The morphological properties were also measured.
Oleogels—Innovative Technological Solution for the Nutritional Improvement of Meat Products
Authors: Perța-Crișan Simona , Ursachi Claudiu-Ștefan , Chereji Bianca-Denisa , Munteanu Florentina-Daniela
Published: December 2022

Food products contain important quantities of fats, which include saturated and/or unsaturated fatty acids. Because of a proven relationship between saturated fat consumption and the appearance of several diseases, an actual trend is to eliminate them from foodstuffs by finding solutions for integrating other healthier fats with high stability and solid-like structure. Polyunsaturated vegetable oils are healthier for the human diet, but their liquid consistency can lead to a weak texture or oil drain if directly introduced into foods during technological processes. Lately, the use of oleogels that are obtained through the solidification of liquid oils by using edible oleogelators, showed encouraging results as fat replacers in several types of foods. In particular, for meat products, studies regarding successful oleogel integration in burgers, meat batters, pâtés, frankfurters, fermented and bologna sausages have been noted, in order to improve their nutritional profile and make them healthier by substituting for animal fats. The present review aims to summarize the newest trends regarding the use of oleogels in meat products. However, further research on the compatibility between different oil-oleogelator formulations and meat product components is needed, as it is extremely important to obtain appropriate compositions with adequate behavior under the processing conditions.
Robust Efficiency Conditions in Multiple-Objective Fractional Variational Control Problems
Authors: Ritu  , Treanţă Savin , Agarwal Divya , Sachdev Geeta
Published: December 2022

The aim of this study is to investigate multi-dimensional vector variational problems considering data uncertainty in each of the objective functional and constraints. We establish the robust necessary and sufficient efficiency conditions such that any robust feasible solution could be the robust weakly efficient solution for the problems under consideration. Emphatically, we present robust efficiency conditions for multi-dimensional scalar, vector, and vector fractional variational problems by using the notion of a convex functional.
How Spatially Resolved Polarimetry Informs Black Hole Accretion Flow Models
Authors: Ricarte Angelo , Johnson Michael D. , Kovalev Yuri Y. , Palumbo Daniel C. M. , Emami Razieh
Published: December 2022

The Event Horizon Telescope (EHT) Collaboration has successfully produced images of two supermassive black holes, enabling novel tests of black holes and their accretion flows on horizon scales. The EHT has so far published total intensity and linear polarization images, while upcoming images may include circular polarization, rotation measure, and spectral index, each of which reveals different aspects of the plasma and space-time. The next-generation EHT (ngEHT) will greatly enhance these studies through wider recorded bandwidths and additional stations, leading to greater signal-to-noise, orders of magnitude improvement in dynamic range, multi-frequency observations, and horizon-scale movies. In this paper, we review how each of these different observables informs us about the underlying properties of the plasma and the spacetime, and we discuss why polarimetric studies are well-suited to measurements with sparse, long-baseline coverage.
The ngEHT’s Role in Measuring Supermassive Black Hole Spins
Authors: Ricarte Angelo , Tiede Paul , Emami Razieh , Tamar Aditya , Natarajan Priyamvada
Published: December 2022

While supermassive black-hole masses have been cataloged across cosmic time, only a few dozen of them have robust spin measurements. By extending and improving the existing Event Horizon Telescope (EHT) array, the next-generation Event Horizon Telescope (ngEHT) will enable multifrequency, polarimetric movies on event-horizon scales, which will place new constraints on the space-time and accretion flow. By combining this information, it is anticipated that the ngEHT may be able to measure tens of supermassive black-hole masses and spins. In this white paper, we discuss existing spin measurements and many proposed techniques with which the ngEHT could potentially measure spins of target supermassive black holes. Spins measured by the ngEHT would represent a completely new sample of sources that, unlike pre-existing samples, would not be biased towards objects with high accretion rates. Such a sample would provide new insights into the accretion, feedback, and cosmic assembly of supermassive black holes.
A Review on Thermal Properties of Hydrogels for Electronic Devices Applications
Authors: Xin Fei , Lyu Qiang
Published: December 2022

Hydrogels, as a series of three-dimensional, crosslinked, hydrophilic network polymers, exhibit extraordinary properties in softness, mechanical robustness and biocompatibility, which have been extensively utilized in various fields, especially for electronic devices. However, since hydrogels contain plenty of water, the mechanical and electrochemical properties are susceptible to temperature. The thermal characteristics of hydrogels can significantly affect the performance of flexible electronic devices. In this review, recent research on the thermal characteristics of hydrogels and their applications in electronic devices is summarized. The focus of future work is also proposed. The thermal stability, thermoresponsiveness and thermal conductivity of hydrogels are discussed in detail. Anti-freezing and anti-drying properties are the critical points for the thermal stability of hydrogels. Methods such as introducing soluble ions and organic solvents into hydrogels, forming ionogels, modifying polymer chains and incorporating nanomaterials can improve the thermal stability of hydrogels under extreme environments. In addition, the critical solution temperature is crucial for thermoresponsive hydrogels. The thermoresponsive capacity of hydrogels is usually affected by the composition, concentration, crosslinking degree and hydrophilic/hydrophobic characteristics of copolymers. In addition, the thermal conductivity of hydrogels plays a vital role in the electronics applications. Adding nanocomposites into hydrogels is an effective way to enhance the thermal conductivity of hydrogels.
Characteristics and Expression Analysis of Invertase Gene Family in Common Wheat (Triticum aestivum L.)
Authors: Wang Chao , Wang Guanghao , Wen Xinyu , Qu Xiaojian , Zhang Yaoyuan , Zhang Xiangyu , Deng Pingchuan , Chen Chunhuan , Ji Wanquan , Zhang Hong
Published: December 2022

Invertase (INV) irreversibly catalyzes the conversion of sucrose into glucose and fructose, playing important role in plant development and stress tolerance. However, the functions of INV genes in wheat have been less studied. In this study, a total of 126 TaINV genes were identified using a genome-wide search method, which could be classified into five classes (TaCWI-α, TaCWI-β, TaCI-α, TaCI-β, and TaVI) based on phylogenetic relationship. A total of 101 TaINVs were collinear with their ancestors in the synteny analysis, and we speculated that polyploidy events were the main force in the expansion of the TaINV gene family. Compared with TaCI, TaCWI and TaVI are more similar in gene structure and protein properties. Transcriptome sequencing analysis showed that TaINVs expressed in multiple tissues with different expression levels. Among 19 tissue-specific expressed TaINVs, 12 TaINVs showed grain-specific expression pattern and might play an important role in wheat grain development. In addition, qRT-PCR results further confirmed that TaCWI50 and TaVI27 show different expression in grain weight NILs. Our results demonstrated that the high expression of TaCWI50 and TaVI27 may be associated with a larger TGW phenotype. This work provides the foundations for understanding the grain development mechanism.
Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out
Authors: Conti Gabriele , D’Amico Federica , Fabbrini Marco , Brigidi Patrizia , Barone Monica , Turroni Silvia
Published: December 2022

Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota–drug interactions have been extensively investigated, but most of the underlying molecular mechanisms still remain unclear. In this review, we discuss the relationship between the gut microbiota and some of the most commonly used drugs in oncological diseases. Different strategies for manipulating the gut microbiota layout (i.e., prebiotics, probiotics, antibiotics, and fecal microbiota transplantation) are then explored in order to optimize clinical outcomes in cancer patients. Anticancer technologies that exploit tumor-associated bacteria to target tumors and biotransform drugs are also briefly discussed. In the field of pharmacomicrobiomics, multi-omics strategies coupled with machine and deep learning are urgently needed to bring to light the interaction among gut microbiota, drugs, and host for the development of truly personalized precision therapies.
Association between INDELs in MicroRNAs and Susceptibility to Gastric Cancer in Amazonian Population
Authors: Modesto Antonio A. C. , Moraes Milene R. de , Valente Cristina M. D. , Costa Marta S. C. R. , Leal Diana F. da V. B. , Pereira Esdras E. B. , Fernandes Marianne R. , Pinheiro Jhully A. dos S. , Pantoja Karla B. C. C. , Moreira Fabiano C. , Burbano Rommel M. R. , Assumpção Paulo P. de , Santos Ney P. C. dos , Santos Sidney E. B. dos
Published: December 2022

Gastric cancer (GC) is a multifactorial, complex, and aggressive disease with a prevalence of one million new cases and high global mortality. Factors such as genetic, epigenetic, and environmental changes contribute to the onset and progression of the disease. Identification of INDELs in miRNA and its target sites in current studies showed an important role in the development of cancer. In GC, miRNAs act as oncogenes or tumor suppressors, favoring important cancer pathways, such as cell proliferation and migration. This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. For this study, 301 patients with GC and 145 individuals from the control group were selected from an admixed population in the Brazilian Amazon. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. The hsa-miR-4463 was significantly associated with clinical features of GC such as diffuse gastric tumor histological type, “non-cardia” localization region, and early onset. Our findings indicated that INDELs could be potentially functional genetic variants for gastric cancer risk.
Loss of Mitochondrial Genetic Diversity despite Population Growth: The Legacy of Past Wolf Population Declines
Authors: Salado Isabel , Preick Michaela , Lupiáñez-Corpas Natividad , Fernández-Gil Alberto , Vilà Carles , Hofreiter Michael , Leonard Jennifer A.
Published: December 2022

Gray wolves (Canis lupus) in the Iberian Peninsula declined substantially in both range and population size in the last few centuries due to human persecution and habitat fragmentation. However, unlike many other western European populations, gray wolves never went extinct in Iberia. Since the minimum number was recorded around 1970, their numbers have significantly increased and then stabilized in recent decades. We analyzed mitochondrial genomes from 54 historical specimens of Iberian wolves from across their historical range using ancient DNA methods. We compared historical and current mitochondrial diversity in Iberian wolves at the 5′ end of the control region (n = 17 and 27) and the whole mitochondrial genome excluding the control region (n = 19 and 29). Despite an increase in population size since the 1970s, genetic diversity declined. We identified 10 whole mitochondrial DNA haplotypes in 19 historical specimens, whereas only six of them were observed in 29 modern Iberian wolves. Moreover, a haplotype that was restricted to the southern part of the distribution has gone extinct. Our results illustrate a lag between demographic and genetic diversity changes, and show that after severe population declines, genetic diversity can continue to be lost in stable or even expanding populations. This suggests that such populations may be of conservation concern even after their demographic trajectory has been reversed.
Integrated Profiles of Transcriptome and mRNA m6A Modification Reveal the Intestinal Cytotoxicity of Aflatoxin B1 on HCT116 Cells
Authors: Wu Yajiao , Bao Wenqiang , Ren Jinjin , Li Chutao , Chen Mengting , Zhang Dongcheng , Zhu An
Published: December 2022

Aflatoxin B1 (AFB1) is widely prevalent in foods and animal feeds and is one of the most toxic and carcinogenic aflatoxin subtypes. Existing studies have proved that the intestine is targeted by AFB1, and adverse organic effects have been observed. This study aimed to investigate the relationship between AFB1-induced intestinal toxicity and N6-methyladenosine (m6A) RNA methylation, which involves the post-transcriptional regulation of mRNA expression. The transcriptome-wide m6A methylome and transcriptome profiles in human intestinal cells treated with AFB1 are presented. Methylated RNA immunoprecipitation sequencing and mRNA sequencing were carried out to determine the distinctions in m6A methylation and different genes expressed in AFB1-induced intestinal toxicity. The results showed that there were 2289 overlapping genes of the differentially expressed mRNAs and differentially m6A-methylation-modified mRNAs. After enrichment of the signaling pathways and biological processes, these genes participated in the terms of the cell cycle, endoplasmic reticulum, tight junction, and mitophagy. In conclusion, the study demonstrated that AFB1-induced HCT116 injury was related to the disruptions to the levels of m6A methylation modifications of target genes and the abnormal expression of m6A regulators.
Development in Fuzzy Logic-Based Rapid Visual Screening Method for Seismic Vulnerability Assessment of Buildings
Authors: Bektaş Nurullah , Kegyes-Brassai Orsolya
Published: December 2022

In order to prevent possible loss of life and property, existing building stocks need to be assessed before an impending earthquake. Beyond the examination of large building stocks, rapid evaluation methods are required because the evaluation of even one building utilizing detailed vulnerability assessment methods is computationally expensive. Rapid visual screening (RVS) methods are used to screen and classify existing buildings in large building stocks in earthquake-prone zones prior to or after a catastrophic earthquake. Buildings are assessed using RVS procedures that take into consideration the distinctive features (such as irregularity, construction year, construction quality, and soil type) of each building, which each need to be considered separately. Substantially, studies have been presented to enhance conventional RVS methods in terms of truly identifying building safety levels by using computer algorithms (such as machine learning, fuzzy logic, and neural networks). This study outlines the background research that was conducted in order to establish the parameters for the development of a fuzzy logic-based soft rapid visual screening (S-RVS) method as an alternative to conventional RVS methods. In this investigation, rules, membership functions, transformation values, and defuzzification procedures were established by examining the data of 40 unreinforced masonries (URM) buildings acquired as a consequence of the 2019 Albania earthquake in order to construct a fuzzy logic-based S-RVS method.
Relationship between Hormonal Changes and Self-Perceived Halitosis in Females: A Cross-Sectional Study
Authors: Alzoman Hamad , Alssum Lamees , Helmi Mohammad , Alsaleh Lama
Published: December 2022

Halitosis is a growing concern for patients seeking dental treatment. Women experience hormonal changes throughout different phases of their life. These changes may affect volatile organic compound (VOC) production and can be linked to halitosis. The aim of this study was to evaluate the effect of hormonal changes on self-perceived halitosis in a sample of females using a self-administered questionnaire. This study used a cross-sectional observational design. The questionnaire was distributed electronically through Google forms. A total of 1089 participants completed the questionnaire. Almost 50% of participants were below the age of 25; and 12% were of menopausal age (defined as 45 years and older). Most participants reported having regular menstrual cycles (63.5%) while only 20% reported having hormonal disturbances. Almost 62% of the sample reported that they notice halitosis on themselves with 27.6% indicating their perception of halitosis occurred at different times of the month. Around 12% of the sample thought that a relationship between halitosis and their menstrual cycle existed with 4.6% reporting halitosis during menstruation. The present study found that regularity of menstrual cycle and hormonal disturbances can affect females’ self-perceived halitosis and the prevalence of oral health symptoms.
Relationship between Medial Elbow Pain, Flexor Pronator Muscles, and the Ulnar Nerve in Baseball Players Using Ultrasonography
Authors: Noda Issei , Kudo Shintarou , Kawanishi Kengo , Katayama Naoya
Published: December 2022

We aimed to clarify changes cross-sectional area (CSA) in flexor pronator muscles and the ulnar nerve (UN) in players with medial elbow pain between pitching phases. Forty-two male baseball players with and without medial elbow pain during throwing were included in this study. The players were divided into maximum external rotation (MER) and ball release (BR) groups according to the pitching phase in which pain was reported. The imaged region was the flexor digital profundus, flexor carpi ulnaris (FCU), flexor digitorum superficialis, and pronator teres muscles, as well as the UN. CSA at rest and during contraction was assessed using the ultrasonography software tracing function. For statistical analysis, the CSA at rest and at contraction in the healthy group, MER group and BR group was compared using one-way analysis of variance. There was a significant difference in CSA only in the FCU between the healthy (95.4 ± 15.5%) and the MER group (76.6 ± 12.5%) at rest (p = 0.004). There were significant differences in the UN between the healthy (105.0 ± 27.7%) and MER groups (176.4 ± 53.5%), and between the healthy and BR groups (132.9±21.1%) (p = 0.001 and p = 0.038, respectively). Our results suggest that athletes with medial elbow pain during the MER of pitching have ulnar nerve swelling.
The Chester Step Test Is a Reproducible Tool to Assess Exercise Capacity and Exertional Desaturation in Post-COVID-19 Patients
Authors: Peroy-Badal Renata , Sevillano-Castaño Ana , Núñez-Cortés Rodrigo , García-Fernández Pablo , Torres-Castro Rodrigo , Vilaró Jordi , Blanco Isabel , Gimeno-Santos Elena
Published: December 2022

Many people recovering from an acute episode of coronavirus disease (COVID-19) experience prolonged symptoms. Exercise testing is a feasible and cost-effective option for assessing exercise tolerance, fatigue, and dyspnea related to effort. Being that the Chester step test (CST) is a progressive, submaximal test for predicting aerobic capacity, it could be a good option to explore. This study aimed to determine the reproducibility of CST for assessing exertional desaturation and exercise capacity in patients post-COVID-19 disease. A cross-sectional study was conducted on post-COVID-19 patients. Two attempts of the CST were performed. The intraclass correlation coefficient (ICC) was used to assess agreement between the two tests. Forty-two symptomatic post-COVID-19 patients were included, the mean age was 53.8 ± 10.3 years, and 52% were female. There was no significant difference between both tests (p = 0.896). Twenty-four percent of participants (10 cases) had a clinically significant decrease in SpO2 at the first assessment, compared to 30.1% (13 cases) at the second, with no significant difference. An ICC of 0.993 (95% CI: 0.987 to 0.996) was obtained for the total number of steps in the CST.
Community Knowledge about Attention Deficit Hyperactivity Disorder in Saudi Arabia: A Cross-Sectional Study
Authors: Abu Alhommos Amal Khaleel , AlHadab Fatimah Mohammed , Alalwan Rwan Adel , Alabduladhem Sara Tawfiq , Alnaser Zahraa Ali , Alnami Sarah Saad
Published: December 2022

Objectives: The majority of earlier studies on knowledge and attitudes around ADHD have been focused on parents of children with ADHD, the child themselves, primary care providers, teachers, and children’s families, and they have found that they have negative perceptions of ADHD. This study aimed to explore community knowledge about ADHD in Saudi Arabia. Methods: A cross-sectional study using an online survey was conducted in Saudi Arabia in January 2022 to explore community knowledge about ADHD in Saudi Arabia. The convenience sampling technique was used to identify eligible participants and invite them to take part in the study. Logistic regression analysis was used to identify ADHD knowledge predictors. Results: A total of 718 participants were involved in this study. The participants in our study showed a weak level of knowledge about ADHD with a mean score of 6.4 (SD: 2.2) out of 17 (which is equal to 37.6% out of the maximum obtainable score). Males, those who work outside the healthcare sector, and those who are retired were less likely to be knowledgeable about ADHD compared to others (p ≤ 0.05). At the same time, participants who reported that they work inside the healthcare sector were more likely to be knowledgeable about ADHD compared to others (p ≤ 0.01). Conclusions: Our study showed that there is insufficient public knowledge about ADHD. The development of educational interventions is necessary to raise public awareness of ADHD. Social media platforms can be used to deliver education campaigns. All members of the community, including parents and those who want to get married, should be the target of these initiatives.
Relationships among Healthcare Providers’ Job Demands, Leisure Involvement, Emotional Exhaustion, and Leave Intention under the COVID-19 Pandemic
Authors: Li Yun-Tao , Chen Shi-Jun , Lin Kuo-Jui , Ku Gordon Chih-Ming , Kao Wen-Yang , Chen I-Shen
Published: December 2022

The COVID-19 pandemic has caused many medical issues. It has tested the impact of healthcare providers’ job demands, emotional exhaustion, and other pressures related to the impact on organizational leave intention. Accordingly, the purpose of this study was to verify the relationship between healthcare providers’ job demands, leisure involvement, emotional exhaustion, and leave intention under the COVID-19 pandemic. The questionnaire survey was used to address the issue of the present study. Convenience sampling was utilized to recruit 440 healthcare providers with a validity rate of 95%. Collected data were analyzed by structural equation modelling. Results indicated that healthcare providers’ job demands do not significantly influence leisure involvement. Job demands significantly influence emotional exhaustion. Job demands significantly influence leave intention. Emotional exhaustion significantly influences leave intention. Emotional exhaustion has a significant mediating effect between job demands and leave intention. Finally, relevant practical suggestions are provided based on the study results.
Mobile Computer Vision-Based Applications for Food Recognition and Volume and Calorific Estimation: A Systematic Review
Authors: Amugongo Lameck Mbangula , Kriebitz Alexander , Boch Auxane , Lütge Christoph
Published: December 2022

The growing awareness of the influence of “what we eat” on lifestyle and health has led to an increase in the use of embedded food analysis and recognition systems. These solutions aim to effectively monitor daily food consumption, and therefore provide dietary recommendations to enable and support lifestyle changes. Mobile applications, due to their high accessibility, are ideal for real-life food recognition, volume estimation and calorific estimation. In this study, we conducted a systematic review based on articles that proposed mobile computer vision-based solutions for food recognition, volume estimation and calorific estimation. In addition, we assessed the extent to which these applications provide explanations to aid the users to understand the related classification and/or predictions. Our results show that 90.9% of applications do not distinguish between food and non-food. Similarly, only one study that proposed a mobile computer vision-based application for dietary intake attempted to provide explanations of features that contribute towards classification. Mobile computer vision-based applications are attracting a lot of interest in healthcare. They have the potential to assist in the management of chronic illnesses such as diabetes, ensuring that patients eat healthily and reducing complications associated with unhealthy food. However, to improve trust, mobile computer vision-based applications in healthcare should provide explanations of how they derive their classifications or volume and calorific estimations.
Trend of Admissions Due to Chronic Lower Respiratory Diseases: An Ecological Study
Authors: Al Rajeh Ahmed M. Al
Published: December 2022

Objective: This study aimed to examine the trend of hospital admissions related to chronic lower respiratory diseases in England and Wales between 1999 and 2020. Method: This ecological analysis used data that were made accessible to the public and were taken from the Patient Episode Database for Wales (PEDW) and the Hospital Episode Statistics (HES) databases in England for the time span between April 1999 and April 2020. The patients were grouped into four age groups: under 15, 15–59, 60–74, and 75 years and above. Results: In 2020, there were 432,193 chronic lower respiratory disease hospital admissions, which increased from 239,606 in 1999. The hospital admission rate increased by 57.5% (from 459.54 (95% CI 457.71–461.38) in 1999 to 723.70 (95% CI 721.55–725.85) in 2020 per 100,000 people, p < 0.5). The majority of hospital admissions for chronic lower respiratory diseases were found to be directly linked to age (more prevalent in the 75+ age group). Moreover, female hospital admission rates for chronic lower respiratory diseases grew by 85.2% between 1999 and 2020, increasing from 445.45 (95% CI 442.92–447.97) to 824.96 (95% CI 821.73–828.19) per 100,000 people. Conclusion: The rate of hospital admissions due to chronic lower respiratory diseases has sharply increased during the past two decades. COPD was the most common cause for chronic lower respiratory disease admissions. Ageing was also found to be a factor in increased hospital admissions. Future studies are warranted to identify other risk factors of hospital admissions due to chronic lower respiratory diseases and specifically COPD.
Parameters of Iliopsoas Plane Immediately Caudal to the Indirect Tendon of Rectus Femoris in Axial Plane Measured on Magnetic Resonance Images in an Adult Eastern Asian Population
Authors: Yeoh Shang-Ru , Chou Yen , Yang Jin-Han , Chuang Ching-Wei , Chan Shun-Ming , Chen Se-Yi , Hou Jin-De , Lin Jui-An
Published: December 2022

The iliopsoas plane (IP) is a fascial plane deep to the iliopsoas complex and is the target of several novel ultrasound-guided analgesic interventions for hip. Currently, limited information is known about its parameters. From the pelvic magnetic resonance (MR) images of an adult Eastern Asian population (n = 49), the IP width, depth, and needle-beam angle in the axial plane immediately caudal to the level of indirect tendon of rectus femoris (RF) were found to be 10.7 ± 1.6 mm, 48.5 ± 15.5 mm, and 84.2 ± 8.2 degrees, respectively. There was a statistically significant difference in the age categories for IP width, and older patients seemed to have wider IP. Our data may provide applications for the technical modification of ultrasound-guided iliopsoas plane block (IPB) in acute hip pain management and the future development of ultrasound-guided single-needle-entry radiofrequency neuroablation in chronic hip pain management.
Effect of Stress on Quality of Life of Shift Nurses in Tertiary General Hospital: The Mediating Effect of Mindfulness
Authors: Hwang Eunhee
Published: December 2022

The purpose of this study was to examine the mediating effects of mindfulness on the relationships between stress and quality of life among shift nurses. A descriptive cross-sectional survey design was conducted using purposive sampling of 206 shift nurses in a tertiary general hospital in Korea. Data were analyzed with descriptive statistics, Pearson correlation and multiple regression analysis using SPSS/WIN 26.0 program. There were significant correlations among stress, mindfulness and quality of life. The quality of life had a positive correlation with mindfulness (r = 0.52, p < 0.001) and a negative correlation with stress among nurses. Mindfulness acts as a mediator in explaining relationship between stress and quality of life. This study provide evidence for the role of mindfulness in the relationship between stress and quality of life in shift nurses. Mindfulness appears to be a protective factor against nurses’ stress. If mindfulness-based interventions are developed and applied to improve the quality of life of shift nurses based on this study, it can help reduce their stress and improve the quality of life, which could ultimately improve the quality of nursing care for patients.
Honor Killings in the Eastern Mediterranean Region: A Narrative Review
Authors: AlQahtani Sarah M. , Almutairi Danah S. , BinAqeel Eman A. , Almutairi Reema A. , Al-Qahtani Reem D. , Menezes Ritesh G.
Published: December 2022

Honor killing is a violent crime committed by one or more perpetrators, in which the crime’s intention is to restore honor to their family. In this narrative review, the authors investigate the epidemiology of honor killing in the Eastern Mediterranean Region. Furthermore, the social, cultural, and legal aspects of honor killing are discussed. Numerous socio-cultural factors lead to the action of killing for honor in this region. They include deeply rooted patriarchal dominance, the desire to maintain social status, and being poorly educated. Honor killing perpetrators have similar characteristics, such as rating female chastity at a higher price and justifying violence against women. The impact of honor killing on family members is much greater than the perceived families’ beliefs of the community’s rejection of the female’s dishonorable behavior. Silence culture dominates these societies, and many crimes are under-reported in this region. Often, a judicial trial is not conducted for such heinous crimes. Penal code reforms, campaigns to promote human rights, steps to improve the education level, and active participation of civil society in condemning such crimes are a few essential measures that need to be considered in order to curb the social evil of honor killing.
Preliminary X-ray Fluorescence Analysis of Metallic Samples from the Chovdar Necropolis in Azerbaijan
Authors: Jalilov Bakhtiyar , Ashurov Safar , Huseynov Muzaffar , Huseynova Lola , Laneri Nicola , Valentini Stefano , Cocciaro Bruno , Legnaioli Stefano , Lorenzetti Giulia , Campanella Beatrice , Raneri Simona , Poggialini Francesco , Palleschi Vincenzo
Published: December 2022

Several samples coming from the recently discovered (February 2019) Late Bronze Age/Early Iron Age Chovdar necropolis in Azerbaijan were analysed using the X-ray fluorescence (XRF) technique. The analysis allowed a preliminary classification of the samples in eight groups based on their composition, obtained from the XRF spectra using the fundamental parameter method. A more detailed classification was then obtained using the graph clustering method.
Prevalence and Subtype Distribution of Blastocystis Isolated from School-Aged Children in the Thai-Myanmar Border, Ratchaburi Province, Thailand
Authors: Abu Amanee , Sutthikornchai Chantira , Mahittikorn Aongart , Koompapong Khuanchai , Chiabchalard Rachatawan , Arthan Dumrongkiet , Soonthornworasiri Ngamphol , Popruk Supaluk
Published: December 2022

Blastocystis is one of the most common enteric protozoa that inhabits the intestinal tract of humans and different animals. Moreover, it has a worldwide geographic distribution. Its main mode of transmission is via the fecal-oral route. At present, 26 subtypes are widely distributed across both humans and animals. The current study aimed to determine the prevalence and subtype distribution of Blastocystis among school-aged children living on the Thai-Myanmar border, Ratchaburi province, Thailand. In total, 508 samples were collected from children at six schools. The prevalence of Blastocystis infection was amplified and sequenced in the 600 bp barcode region of the small-subunit ribosomal RNA (SSU rRNA). The overall prevalence of Blastocystis infection was 3.35% (17/508). ST3 (11/17) was the most predominant subtype, followed by ST1 (5/17) and ST2 (1/17). A phylogenetic tree was constructed based on the Tamura92+G+I model using the maximum-likelihood algorithm. Surprisingly, all sequences of the ST3-positive samples were closely correlated with the cattle-derived sequence. Meanwhile, all sequences of the Blastocystis ST1-positive samples were closely correlated with the human-derived sequence. Nevertheless, further studies should be conducted to validate the zoonotic transmission of Blastocystis. Based on our findings, personal hygiene and sanitation should be improved to promote better health in children in this area.
Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults
Authors: Ueyama Jun , Hayashi Mai , Hirayama Masaaki , Nishiwaki Hiroshi , Ito Mikako , Saito Isao , Tsuboi Yoshio , Isobe Tomohiko , Ohno Kinji
Published: December 2022

Animal experiments have indicated that pesticides may affect gut microbiota, which is responsible for the production of short-chain fatty acids (SCFAs) and polyamines. Here, we present a preliminary observation of the relationship between pesticide exposure and fecal SCFAs and polyamines in Japanese adults. In total, 38 healthy adults aged 69 ± 10 years (mean ± SD) were recruited and subjected to stool and spot urine tests. Urinary dialkylphosphates (DAP), 3-phenoxybenzoic acid, and glyphosate were assayed as pesticide exposure markers of organophosphorus insecticide (OP), a pyrethroid insecticide, and glyphosate, respectively. Significant negative correlations (p < 0.05, Spearman’s rank correlation coefficient) were found between urinary DAP, fecal acetate (r = −0.345), and lactate (r = −0.391). Multiple regression analyses revealed that urinary DAP was a significant explanatory variable of fecal acetate concentration (p < 0.001, β = −24.0, SE = 4.9, t = −4.9) with some vegetable intake (adjusted R-square = 0.751). These findings suggest that OP exposure is independently associated with lower fecal acetate levels, which may contribute to human health in middle-aged and older adult groups. Given that the human gut environment has long-term effects on the host, studies on wide-range age groups, including children, are necessary.
Dental Care for Older Adults
Authors: Leung Katherine Chiu-Man , Chu Chun-Hung
Published: December 2022

There is a global increase in the older population. Unfortunately, dental conditions in the older population can sometimes be poor as a result of worsened physical conditions and the cumulative damage caused by dental diseases in the past. Many suffer from oral diseases such as dental caries and periodontal disease but receive no regular dental care. Oral conditions and systemic problems are interrelated. Chronic medical problems and polypharmacy are common among them. These conditions may lead to xerostomia with or without a decrease in saliva output. Additionally, many older adults have deteriorated masticatory function associated with physical health issues such as frailty. Preventive measures are crucial to stop oral diseases from progressing and the replacement of missing teeth is needed when masticatory function is impaired. Older adults also suffer a higher risk of oral cancer because of their less resilient but more permeable oral mucosa. With the increasing need for elderly dental care, dentists should equip themselves with knowledge and skills in geriatric dentistry. They should help older adults to develop and maintain the functional ability that enables well-being in older age. This communication article aims to discuss the relevant medical conditions, common dental diseases, and dental care for older adults.