bluuebunny/crossref_metadata_2025 huggingface dataset:
CYPERUS ROTUNDUS TUBERS EXTRACT INHIBITS STEM CELL MARKERS EXPRESSION IN CERVICAL AND HUMAN GLIOBLASTOMA CANCER CELL LINES
Authors:   Dept. of Molecular Biology, Iraqi Center for Cancer and Medical Genetics Research, Baghdad, Iraq, Abdulghany Zaynab , Mahmood Noah ,   Dept. of Molecular Biology, Iraqi Center for Cancer and Medical Genetics Research, Baghdad, Iraq, Tawfeeq Amer ,   Dept. of Molecular Biology, Iraqi Center for Cancer and Medical Genetics Research, Baghdad, Iraq, Yassen Nahi ,   Dept. of Molecular Biology, Iraqi Center for Cancer and Medical Genetics Research, Baghdad, Iraq
Published: February 2022

Background: Cancer stem cell markers known for their ability to induce tumor initiation, angiogenic activity, therapy resistance and metastasis formation. Plant extract potentially was used to treat cancer and/or target its genes. Cyperus rotundus tubers extract has been used in ancient as a folk medicine for its antibacterial, anti-diabetic and for other maladies for its antioxidant properties that have been estimated in modern medicine. Objective: To determine the effects of total oligofalvonoids (TOF) extracted from Cyperus rotundus tubers against cervical cancer cells line (HeLa) and human glioblastoma (AMGM) cell line. Methods: Cytotoxicity of TOF extract against both cancer cell lines was determined after 24 hr of exposure and the best concentration of inhibition was 350 µg/ml. Total RNA extracted from both cell lines after treated with TOF and the expression levels of cancer stem cell markers OCT3/4 as well as matrix metalloproteinasese MMP2 and MMP9 have been measured using quantitative real time polymerase chain reaction. Results: Cytotoxicity of TOF extract with concentration (350 µg/ml) shown to reduce the growth of cancer cell lines after 24 hr of exposure. The expression level of OCT3/4 was highly significantly reduced in both AMGM and HeLa cells after treated with TOF and the fold change reduced from (15 to 0.03) and (10 to 0.09), respectively. On the other hand, the expression levels of MMP2 and MMP9 were significantly decreased in AMGM and HeLa cells treated with TOF extract with decreasing in fold change from (10.2 to 0.02) for MMP2 in AMGM cells and (1.85 to 0.5) for MMP9. And fold change of MMP2 expression in HeLa cells was decreased after treated with TOF from (11.1 to 0.01) and for MMP9 (11.43 to 0.08). Conclusion: The result indicates that the inhibition of cancer stem cell markers OCT3/4 and MMP2 and MMP9 may provide a novel strategy to treat cancer using a natural plant extract. Keywords: Cancer stem cell markers, AMGM cells, Hela cells Citation: Abdulghany ZS, Mahmood NA, Tawfeeq AT, Yassen NY. Cyperus Rotundus Tubers extract inhibits stem cell markers expression in cervical and human glioblastoma cancer cell lines. Iraqi JMS. 2018; 16(2): 159-165. doi: 10.22578/IJMS.16.2.7
THE VALUE OF MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF PERI-ANAL FISTULA
Authors:   Dept. of Surgery, College of Medicine, Al-Nahrain University, Baghdad, Iraq, Jawad Ammar , kadhim Mohammed ,   Dept. of Surgery, College of Medicine, Al-Nahrain University, Baghdad, Iraq, Al-Jobouri Zainab ,   Dept. Al-Imamein Al-Kadhimein Medical City, Baghdad, Iraq, Hussain Mohssin ,   Dept. Al-Imamein Al-Kadhimein Medical City, Baghdad, Iraq
Published: February 2022

Background: Perianal fistula accounts for 0.01% of general population and is frequently managed inadequately resulting in a significant morbidity. Magnetic resonance imaging (MRI) plays an essential role in the preoperative assessment of the disease, therefore improving post-operative surgical outcome. Objective: To study the role of MRI in the evaluation of perianal fistula and to show the value of using contrast enhanced MR study in the determination of the precise tract pathway, extensions and other associated pathologies. Methods: A cross sectional analytic study was conducted on a total of 32 patients with perianal fistulas in the MRI Department of Al-Imamein Al-Kadhimein Medical City, Baghdad, Iraq during the period from November 2015 to December 2016. Patients underwent MRI examination using axial and coronal T2 weighted images with and without fat suppression and T1 fat suppressed sequences before and after contrast administration. The type of fistula, location of the internal opening, associated abscesses and/or sinus tracts and horseshoe extension were evaluated using different MR sequences. Results: The most common type of fistula encountered was the inter-sphincteric type, which was seen in 21 patients (66%), of those patients 16 fistulas (50%) were grade I and 5 fistulas (16%) were grade II. Trans-sphincteric fistulas were seen in 9 patients (28%), 2 of them (6%) were grade III and 7 fistulas (22%) were grade IV. Two patients (6%) had extra-sphincteric type. T2 weighted TSE, T2 TSE with fat suppression and T1 weighted fat suppressed post contrast sequences all show significant correlation with surgical results (with p-value less than 0.05) and the highest significance was obtained by the post contrast sequence (p-value of 0.00001). The highest accuracy in the diagnosis of fistula in ano was with the use of T1 enhanced fat suppressed sequence (98.8%) followed by 87% for the T2 fat suppression sequence and only 57% for the T2 weighted TSE sequence. Conclusion: MRI is an essential, noninvasive tool in the preoperative assessment of perianal fistulous tracks, with the axial and coronal post contrast fat suppression T1 providing the highest accuracy and clinical significance with surgical data and therefore giving a highly promising decrement in the incidence of post-operative complications. Keywords: MRI, perianal fistula Citation: Jawad AM, kadhim MA, Al-Jobouri ZK, Hussain MAA. The value of magnetic resonance imaging in the evaluation of peri-anal fistula. Iraqi JMS. 2018; 16(2): 166-176. doi: 10.22578/IJMS.16.2.8
EVALUATION OF PHOSPHO-AKT IMMUNOHISTOCHEMICAL EXPRESSION IN PATIENTS WITH LARYNGEAL SQUAMOUS CELL CARCINOMA
Authors:   Dept. of Nursing Techniques, Alsuwayrah Technical Institute, Middle Technical University, Iraq, Wanas Nisreen , Mehdi Luma ,   Dept. of Medical Laboratory Techniques, College of Health and Medical Technologies, Middle Technical University, Iraq,, Alzubaidi Liqa ,   Dept. of Medical Laboratory Techniques, Technical Institute, Northern Technical University, Mosul
Published: February 2022

Background: Akt, is a serine/threonine protein kinase which act as an important regulator of cell proliferation and survival. The Akt complex is upregulated by phosphorylation producing phospho-Akt, which trigger a continued cell proliferation and survival and inhibit apoptosis, thereby promote cell survival. Objective: To evaluate the immunohistochemical expression of phosphorylated Akt (Phospho-Akt) in laryngeal squamous cell carcinoma (SCC) and to be correlated with different clinicopathological parameters. Methods: Phospho-Akt expression was investigated Immunohistochemically in 49 formalin-fixed paraffin embedded laryngeal SCC tissue sections collected from Teaching laboratories - Baghdad Medical City. Results: Phospho-Akt positive immunostaining appears in 57% of samples. Akt activation present in advanced stages of tumors with p value 0.02. Conclusion: The current findings may provide evidence that aberrant expression of Akt contributes to the pathogenesis (mechanism of disease development) of laryngeal SCC. Keywords: Akt, phospho-Akt, immunohistochemistry, laryngeal SCC, larynx Citation: Wanas NS, Mehdi LY, Alzubaidi LKA. Evaluation of phospho-AKt immunohistochemical expression in patients with laryngeal squamous cell carcinoma. Iraqi JMS. 2018; 16(2): 177-181. doi: 10.22578/IJMS.16.2.9
The implementation of Herringbone technique to improve reading comprehension
Authors:   Universitas Lampung, Nadira Salsabila , Huzairin Huzairin ,   Universitas Lampung, Burhanuddin Burhanuddin ,   Universitas Lampung
Published: February 2022

The objectives of this research were to find out whether there was a significant difference of the students’ reading comprehension after the implementation of Herringbone technique and to investigate which aspect of reading that improves the most and improves the least after the implementation of the technique. The population of this research was the first grade of SMA Tri Sukses Natar in the academic year 2019/2020. The sample of this research was X science 2 which consisted of 30 students. The data were taken from the tests and they were analyzed by using paired sample t-test. The result showed that there was a significant difference in the students’ reading comprehension of pre-test (61.40) to post-test (72.30) in which t-value>t-table (11.882>2.452) or sig p<0.05 (0.000<0.05). In addition, main idea was the aspect of reading that improved the most after the implementation of the technique and the aspect which improved the least was vocabulary. Based on the result, it can be concluded that Herringbone technique is effective to improve students’ reading comprehension. Keywords: Herringbone technique, Reading comprehension, Narrative text
Análisis contrastivo entre dos variantes del español (potosina y sinaloense) sobre los compuestos sintagmáticos de estudiantes de secundaria en los estudios de disponibilidad léxica mexicana
Authors: Pérez Durán Marco Antonio
Published: February 2022

En este trabajo se analizan los compuestos sintagmáticos aparecidos en las listas de disponibilidad léxica de dos corpus diferentes: Culiacán, Sinaloa, obtenido entre 2007-2008, y San Luis Potosí, obtenido en 2017, ambos en estudiantes de secundaria dentro de los estudios de disponibilidad léxica mexicana. El objetivo de este trabajo consiste en demostrar que los compuestos sintagmáticos aparecidos en dos corpus de disponibilidad léxica mexicana presentan mínima variación porcentual, a pesar de que existe una diferencia temporal de 10 años entre cada uno de ellos. La metodología aplicada es del tipo cuantitativo-contrastivo y consistió en contabilizar y clasificar los compuestos sintagmáticos de acuerdo con su estructura: [N+A]N, [A+N]N, [N+p+N]N y [N+N]N. Además, el análisis realizado permitió obtener los cinco compuestos sintagmáticos más disponibles en cada centro de interés en ambas muestras. Las conclusiones alcanzadas son que los compuestos del tipo [N+A]N y [N+p+N]N son productivos en los centros: 08, La escuela: muebles y útiles; 10, La ciudad; 14, Animales y 16, Profesiones y oficios, mientras que el compuesto del tipo [N+N]N es más productivo en los centros: 01, Partes del cuerpo; 02, La ropa: el vestido y el calzado y 03, La casa: el interior y sus partes.
Tarımsal Yapı, Kırsal Alan ve Demografide Değişim
Authors: Demirbük Murat
Published: February 2022

Structures of agricultural holdings have been changing rapidly in rural areas. While smallholders have been decreasing in number, the number of large farms has been increasing. Youth has been rapidly moving away from agriculture. The agricultural sector has faced an aging problem. The involvement of youth and smallholders in agricultural production is extremely important for food supply security. This study aimed to observe the structural change of agricultural holdings based on the Farmer Registration System (FRS) data. The answers to the following questions were sought. Has the numerical and proportional distribution of enterprises changed according to their size? Has youth been moving away from agriculture? FRS records between 2003-2020 were used in the study. Agricultural holdings were grouped according to their size and the age of farmers. Results were summarized in tables and graphics. There was a decrease in the number and rate of farmers under the age of 40, and a proportional increase in the number of farmers over 65. While the number of agricultural holdings larger than 500 increased 2.5 times, the number and rate of small farms decreased. Migration from the districts and villages in the study area has been observed at rates ranging from 22% to 59% in 20 years. Special measures should be taken for youth and small farms to survive in the agricultural sector. Tools such as tax exemption and social security support can be used. Integrated rural development approaches, including basic services such as education and health, are indispensable for the population to be permanent in rural areas.
Moleküler Hidrojenin Tarım Alanında Kullanımı
Authors: Alwazeer Duried , Çiğdem Ayhan
Published: February 2022

Social development is possible with agriculture. With the impact of environmental pollution, natural disasters, climate change, food security, and population growth, interdisciplinary "new agriculture" is becoming an important trend of modern agriculture. Hydrogen (H2) is the most common element on earth, making up more than 75% of the mass of the universe. Hydrogen gas is colorless, odorless, and tasteless and is considered a physiologically inert molecule and a potential source for clean energy in the future. Hydrogenated agriculture including mainly hydrogen-rich water (HRW) focuses on the molecular mechanisms underlying improved agricultural product quality. Studies have shown that H2 does not only affect plant growth and development but also affects the nutritional quality and shelf life of the fruit. Hydrogenated agriculture emerges as a promising technology for the sustainability of agricultural products in modern agricultural practices thanks to the different beneficial effects of H2 such as safety, nutritional and antioxidative properties, and high product productivity. In this review, the roles of H2 in plants, seed germination, seedling growth, root development, stomatal opening and closing, pre-harvest freshness, post-harvest freshness, and the changes caused by hydrogenated agriculture at various stages of the plant such as anthocyanin synthesis have been investigated.
Trichoderma harzianum Suşlarının Domates Fide Kalitesine Etkileri
Authors: İkiz Orkun , Öztekin Gölgen Bahar , Tüzel Yüksel , Karaçancı Şevket , Tepecik Mahmut
Published: February 2022

This study was conducted to determine the effects of Trichoderma harzianum on seedling growth and quality as two consecutive experiments during the spring months of 2018. In the first experiment, four different T. harzianum strains and a commercial preparate were used by adding into seed sowing substrate and compared with control group which had no treatment. The most promising strain (strain2), was used with and without foliar fertilizer (20:20:20) and foliar fertilizer itself was considered as control. Emergence period and rate were determined to observe the effects of treatments of germination of seeds. Regarding the seedling growth and quality, seedling length, root length, hypocotyl diameter, leaf thickness, fresh and dry weights of root and shoots, dry matter content, color, chlorophyll index, leaf macro and micro plant nutrient contents and seedling quality index were determined at the planting stage. Data obtained from the first experiment showed that the effects of T. harzianum strains on seedling morphology, physiology and nutrient content were different. Among the tested strains, strain2 showed better performance on seedling length, root and shoot dry matter contents, total fresh weight, chlorophyll, a color value and P, Ca, Mn, Cu and Zn contents of leaves and improved seedling quality. The second experiment result showed that the foliar fertilizer application increased the efficiency of T. harzianum strain2. T. harzianum strain2 without foliar fertilizer remained below the control treament in all measured parameters. When all the data were evaluated together, it was concluded that T. harzianum could be used to increase seedling quality due to its positive effects on seedling biomass, plant nutrition uptake and quality index. Moreover, it can be used in organic seedling production as alternative biostimulant.
Genç Çiftçi Projesi Desteğinden Yararlanma Durumunu Etkileyen Faktörlerin Belirlenmesi: Akdeniz Bölgesi Örneği
Authors: Uysal Osman , Birol Duygu
Published: February 2022

This study aims to determine the characteristics of young farmers and their businesses that benefit from and cannot benefit from young farmer support in the Mediterranean Region and determine the factors that affect the benefit of young farmer project support. In 2016, a survey was conducted with all 160 producers who benefited from young farmer support, and a survey was conducted with 56 producers who applied for young farmer project support but could not benefit from it to make comparisons between groups. The tendency of farmers to benefit from the young farmer support project was determined using artificial neural networks and logistic regression analysis. It was determined that the majority of the producers who received support only made animal production and mixed production (livetock production and vegetable production), while the majority of the producers who did not receive support made only plant production. With both analysis methods, it was determined that the most critical variables that affect the benefit of young farmer project support are the type of activity, the share of non-agricultural income in total income, the number of farmers in the family, the education period, the status of having non-agricultural income and family size. The total correct classification rate was found to be 87.04% in the logistic regression analysis and 91.20% in the artificial neural network analysis, and it was seen that the classification percentages obtained by both methods were quite close to each other.
Osmaniye Yöresinde Doğal Olarak Yetişen Defne (Laurus nobilis L.), Murt (Myrtus communis L.) Bitkilerinin Uçucu Yağ Oran ve Bileşenlerinin Belirlenmesi
Authors: Koçer Oğuzhan , Türkmen Musa , Eren Yılmaz
Published: February 2022

Medicinal and aromatic plants are divided into two groups, collected from nature and grown.Medicinal and aromatic plants collected from nature grow spontaneously in natural places such as forests. Two of these plants found in the Mediterranean region are Laurus nobilis L. and Myrtus communis L. This study was conducted to determine the ratios and components of essential oils obtained from laurel trees and myrtle plants. The leaves obtained from these plants, which grow intensively in the flora of Osmaniye Province of Turkey, were obtained by using the water vapor distillation method in large distillation boilers (retort) in industrial applications and their essential oils were obtained. The essential oil ratios obtained by retort methods were observed dec 0.9-1.4% in laurel plant and 0.4-0.8% in myrtle plant. The components of essential oil were examined, the Laurel main components α-pinene (5.75%), sabine (the to 8.9%), eucalyptol (44.42%) and α-acetate terpinyl (17.37%) is designated as the main components of the plant and Mersin, α-pinene (50.79%), limonene (4.08%), eucalyptol (31.66%), α-terpineol (5.57%), α-terpinyl acetate (2.37%) has been identified as.
2000 Yıllardan Günümüze Türkiye Arıcılığının Değerlendirilmesi
Authors: Şahinler Nuray , Toy Nesibe Özge
Published: February 2022

Beekeeping; It is a branch of agriculture that provides cheap and easy employment opportunities, is not dependent on land, is a sole source of livelihood for families with landless or little land and has no harmful effects on the environment and nature. Our current geographical location is among the countries suitable for beekeeping in our country with the coexistence of four seasons. Beekeeping has become widespread in our country with the increasing interest in natural life and natural products, with developing technologies day by day. When the data from the 2000s to the present are examined, it is noteworthy that the number of hives has increased every year. In the last twenty (2000-2020) years, there has been an increase of 11.29% in the number of old hives, and an increase of 95.62% in the number of new hives. At the same time, it was determined that there was an increase of 70.36% in honey production and a decrease of 16.83% in bee wax production. In this review article, the current situation of beekeeping, which is the branch of animal husbandry in Turkey, together with 20 years of data has been examined.
Samsun İli Ondokuz Mayıs İlçesi Süt Sığırcılığı İşletmelerinin Genel Özellikleri ve Bazı Yetiştiricilik Uygulamalarının Süt Verimi Üzerine Etkileri
Authors: Satılmış Murat , Atasever Savaş
Published: February 2022

In this study, it was aimed to reveal the structural properties and the effects of husbandry practices on milk yield in dairy farms of Ondokuz Mayıs district of Samsun. While the data were obtained by face-to-face surveys and observations in a total of 59 farms those had ≥10 head cattle between January and June 2018, environmental factors affecting daily milk yield (DMY) were separately evaluated. Important negativeneses were determined on the barn type, bedding material using, calving pens, weaning period of calves, claw care and udder cleaning in the farms. It was informed that local bazaars and cooperatives were commonly used for raw milk marketing, and high feed price was the most important problem. DMY was significantly affected by the experience of farm owner, number of the milking cows, amount of concentrate feed that given and milking type. It was concluded that farm properties and herd management methods have to be restored to elevate milk production in the investigated farms.
Kırklareli Kenti Örneğinde Kentsel Tarımın Sürdürülebilir Kentsel Gelişime Katkılarının İncelenmesi
Authors: Aslan Fürüzan , Menteş Yaşar , Ateş Oğuz
Published: February 2022

The aim of this study; To combat the problems arising from rapid population growth and irregular urbanization in ecological terms, to ensure the integration of agriculture with the city and to develop strategies in order to ensure human health, environmental health, food safety, urban aesthetics, social integration and urban sustainability. As the study area, the adjacent area of Kırklareli has been considered. A 4-stage method was determined in the study. In the first stage, a literature review was conducted on the subject. In the second stage; The collection and examination of natural and socio-cultural data for Kırklareli province was carried out. In the third stage; As a result of the analyzes made, field observations were made and it was determined in which neighborhoods the most suitable urban agriculture model could be applied to the city of Kırklareli. In the last stage, in line with the available data and potentials for the city of Kırklareli, important strategies for the implementation of urban agriculture studies were developed and various suggestions were made.
Photo-induced processes of iron oxide nanoparticles to enhance laser therapy
Authors: Pominova D. V. , Romanishkin I. D. , Plotnikova E. A. , Morozova N. B. , Loschenov V. B. , Wittig R. , Linden M. , Steiner R. W. , Ryabova A. V.
Published: February 2022

Nanoparticles are used as drug carriers to increase the selectivity and effectiveness of therapy, as well as for combined therapy that utilizes different effects. Iron oxide nanoparticles are promising in this aspect. Due to magnetic properties, they can be used as a contrast agent for magnetic resonance imaging. Also, iron oxide nanoparticles could be coated with a photosensitizer for photodynamic therapy and their laser or magnetic heating can be used for phototherapy. Local enhancement of the electromagnetic field near iron oxide nanoparticles can increase the fluorescence intensity of photosensitizers and the efficiency of singlet oxygen generation. This paper presents the results of a study of iron oxide nanoparticles focused on the photophysical aspects of the formation of “hot spots” under laser irradiation. The photoinduced effects of iron oxide nanoparticles observed in in vitro experiments lead to the rupture of lysosomes. Theoretical modeling showed that the heating of iron oxide nanoparticles with a radius of 35 nm under the action of laser radiation is about 89°C and 19°C for wavelengths of 458 and 561 nm, respectively. Local field enhancement occurs in pairs of nanoparticles of various sizes and strongly depends on the distance between them. The maximum gain is achieved at small distances between nanoparticles. For a dimer of nanoparticles with radii of 10 and 35 nm at a distance of 1 nm, an enhancement factor of two orders of magnitude was obtained. The investigated phenomenon of «hot spots» is in demand for precision therapy, because the photo-induced processes occur at small distances between nanoparticles, in areas of their high accumulation.
Depositional Environment and Microfacies Analysis of Yamama Formation in North Rumaila Oil Field, South Iraq
Authors: Mohammed Noor Alhuda , Nasser Medhat E.
Published: February 2022

Yamama Formation is an important sequence in southern Iraq. Petrographic analysis was used to determine and analyze the microfacies and pore types. The diagenetic processes and the impacts on the petrophysical properties of the rocks were also identified. The petrographic identification was based on data of 250 thin sections of cutting and core samples from four wells that were supplied by the Iraqi Oil Exploration Company (O.E.C). The present study focuses on the depositional environment and the microfacies analysis of Yamama Formation. The results revealed several types of microfacies, including  peloidal wackestone-packstone, algal wackestone-packstone, bioclastic wackestone-packstone, foraminiferal wackestone, bioclastic wackestone, and  mudstone. The latter was divided into two submicrofacies, namely argillaceous lime mudstone and sparse fossiliferous lime mudstone. The study showed that Yamama Formation was deposited through various settings within the carbonate platform; these comprise inner ramp, middle ramp, and outer ramp settings. The inner and middle ramp settings, characterized at the top and middle Formation, have high effective porosity and low clay volume, due to dominant packstone.
Direct sum of π-projective semimodules
Authors: Altaee Muna M. T. , Alhossaini Asaad. A. M.
Published: February 2022

Let A, and N  are a semiring ,and  a left A- semimodule, respectively. In this work we will discuss two cases: 

The direct summand of π-projective semi module is π-projective, while the direct sum of two π-projective semimodules in general is not π-projective . The details of the proof will be given.

We will give a condition under which the direct sum of two π-projective semi modules is π-projective, as well as we also set conditions under which π-projective semi modules are projective.
The Effectiveness of Gait Retraining on Running Kinematics, Kinetics, Performance, Pain, and Injury in Distance Runners: A Systematic Review With Meta-analysis
Authors: Doyle Eoin , Doyle Tim L. A. , Bonacci Jason , Fuller Joel T.
Published: February 2022

Objective

To evaluate the effectiveness of running gait retraining on kinematics, kinetics, performance, pain, and injury in distance runners.

Design

Intervention systematic review with meta-analysis.

Literature Search

Seven electronic databases from inception to March 2021.

Trial Selection Criteria

Randomized controlled trials that (1) evaluated running gait retraining compared to no intervention, usual training, placebo, or standard care and (2) reported biomechanical, physiological, performance, or clinical outcomes.

Data Synthesis

Random-effects metaanalyses were completed, and the certainty of evidence was judged using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. We categorized interventions into step rate, non-rearfoot footstrike, impact, ground contact time, and multiparameter subgroups.

Results

We included 19 trials (673 participants). Moderate-certainty evidence indicated step rate gait retraining increased step rate (SMD 1.03 [95% confidence interval {CI}: 0.63, 1.44]; number of trials (N): 4; I2: 0%) and reduced average vertical loading rate (SMD −0.57 [95% CI, −1.05 to −0.09], N: 3; I2: 0%). Low-certainty evidence indicated non-rearfoot footstrike retraining increased knee flexion at initial contact (SMD 0.74 [95% CI, 0.11 to 1.37]; N: 2; I2: 0%), but did not alter running economy (SMD 0.21 [95% CI, −1.11 to 1.52]; N: 3; I2: 19%).). Low-certainty evidence indicated multiparameter retraining did not alter running economy (SMD 0.32 [−0.39, 1.02]; N: 3; I2: 19%) or performance (SMD 0.14 [95% CI, −4.87 to 4.58]; N: 2; I2: 18%). Insufficient trials reported on pain outcomes. Two trials demonstrated reduced 1-year injury incidence following gait retraining.

Conclusions

Gait retraining interventions altered step rate and knee kinematics, lowered vertical loading rates, and did not affect running performance. J Orthop Sports Phys Ther 2022;52(4):192–206. Epub 05 Feb 2022. doi:10.2519/jospt.2022.10585
Measurement Properties of the Patient-Specific Functional Scale and Its Current Uses: An Updated Systematic Review of 57 Studies Using COSMIN Guidelines
Authors: Pathak Anupa , Wilson Ross , Sharma Saurab , Pryymachenko Yana , Ribeiro Daniel Cury , Chua Jason , Abbott J Haxby
Published: February 2022

Objective

To systematically review measurement properties, including acceptability, feasibility, and interpretability, and current uses of the Patient-Specific Functional Scale (PSFS).

Design

Systematic review of a patient-reported outcome measure using the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) guidelines.

Literature Search

We searched 11 databases from January 2010 to July 2020 for articles on measurement properties or use of PSFS.

Study Selection Criteria

Published primary articles without language restrictions.

Data Synthesis

Two independent reviewers screened all records, extracted data, and performed risk of bias assessments using COSMIN guidelines. We qualitatively synthesized findings for each measurement property in musculoskeletal and nonmusculoskeletal conditions, and 2 reviewers independently performed Grading of Recommendations Assessment, Development and Evaluation assessments. This study was preregistered with the Open Science Framework ( https://doi.org/10.17605/OSF.IO/42UZT ).

Results

Of the 985 articles screened, we included 57 articles on measurement properties and 255 articles on the use of PSFS. The PSFS had sufficient test-retest reliability in musculoskeletal (22 studies, 845 participants, low-to-moderate certainty) and nonmusculoskeletal conditions (6 studies, 197 participants, very low certainty), insufficient construct validity as a measure of physical function (21 studies, 2 945 participants, low-to-moderate certainty), and sufficient responsiveness (32 studies, 13 770 participants, moderate-to-high certainty). The standard error of measurement ranged from 0.35 to 1.5. The PSFS was used in 87 unique health conditions, some without prior evidence of validity.

Conclusion

The PSFS is an easy-to-use, reliable, and responsive scale in numerous musculoskeletal conditions, but the construct validity of PSFS remains uncertain. Further study of the measurement properties of the PSFS in nonmusculoskeletal conditions is necessary before clinical use. J Orthop Sports Phys Ther 2022;52(5):262–275. Epub: 05 Feb 2022. doi:10.2519/jospt.2022.10727
PREDIKSI PERTUMBUHAN PERBANKAN SYARIAH DI INDONESIA TAHUN 2022
Authors: Widodo Rudy , Adhidharma Galih , M. Arna Ramadhan
Published: February 2022

Penelitian ini bertujuan untuk memprediksi pertumbuhan perbankan syariah tahun 2022 di Indonesia yang dilihat dari aspek aset, pembiayaan, dan dana pihak ketiga. Data yang digunakan pada penelitian ini yaitu data aset, pembiayaan, dan dana pihak ketiga perbankan syariah periode Januari 2011  sampai dengan September 2021. Variabel penyerta yang digunakan untuk memprediksi pertumbuhan perbankan syariah adalah Return on Asset (ROA), Not Perfoming Financing (NPF), inflasi, BI rate, Indesk Harga Saham Gabungan (IHSG), dan Gross Domestic Product (GDP). Analisis data menggunakan metode forecasting ARIMA (Autoregressive Integrated Moving Average), ARIMAX (Autoregressive Integrated Moving Average with Explanatory Variables), dan VAR (Vector Autoregressive). Hasil penelitian menunjukkan bahwa aset, pembiayaan, dan dana pihak ketiga perbankan syariah tahun 2022 tetap akan mengalami pertumbuhan yang positif dimana besaran aset perbankan syariah diprediksi mencapai 694 hingga 734 triliun rupiah. Pertumbuhan pembiayaan mencapai 452 hingga 470 triliun rupiah dan pertumbuhan dana pihak ketiga mencapai 549 sampai dengan 575 triliun rupiah.
China’s Development of Gwadar as a Regional Maritime Hub
Authors: Iqbal Rahat , Jan Inamullah , Yousafzai Zafar Iqbal
Published: February 2022

Purpose: This article aims at analyzing China’s development of Gwadar as a maritime hub in the region. Gwadar, after Karachi and Bin Qasim Port is the third seaport of Pakistan, which has a greater impact not only on Pakistan but also on regions, especially China. Moreover, the paper through light on the features of CPEC which connects Gwadar with China. Challenges which Gwadar has to face in the near future are also analyzed.

Methodology: Qualitative and analytical method is used to conduct this research.

Findings: The paper concludes that Gwadar is a potential maritime economic hub in the region.

Implications: Hence, the joint venture will not only bring multiple benefits to China-Pakistan but also bring opportunities to the adjacent regions: Central Asia, Middle East and Persian Gulf.
KRIM ANTIOKSIDAN EKSTRAK ETANOL DAUN KOPI ARABIKA (Coffea Arabica)
Authors: Puspitasari Anita Dwi
Published: February 2022

Daun kopi arabika mengandung senyawa antara lain flavonoid yang berpotensi sebagai antioksidan alami yang dapat menghambat radikal bebas. Penelitian sebelumnya menunjukkan bahwa ekstrak etanol daun kopi arabika memiliki aktivitas antioksidan dengan nilai IC50 sebesar 19,856 ± 0,126 µg/ml. Penelitian ini bertujuan untuk mengetahui nilai IC50 dari krim ekstrak etanol daun kopi arabika dengan menggunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) dan karakteristik fisika kimia sediaan krim.  Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 70%, kemudian dilakukan uji kualitatif senyawa flavonoid. Variasi konsentrasi ekstrak dalam krim adalah 0,1%, 0,2%, dan 0,3%. Aktivitas antioksidan krim diuji dengan metode DPPH serta diamati karakteristik fisik kimia krim meliputi organoleptis, homogenitas, pH, daya lekat, viskositas, dan daya sebar. Data uji kualitatif senyawa flavonoid ditujukan untuk senyawa flavanoid, selanjutnya stabilitas fisika krim dianalisis menggunakan regresi linier, uji aktivitas sediaan krim dihitung menggunakan persentase aktivitas antioksidan dan uji aktivitas antioksidan ekstrak dihitung menggunakan nilai IC50. Hasil penelitian menunjukkan ekstrak etanol daun kopi arabika mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Hasil uji aktivitas antioksidan ekstrak daun kopi arabika diperoleh nilai IC50 sebesar 3,578 µg/ml, sedangkan kuersetin diperoleh nilai IC50 sebesar 15,09 µg/ml. Hasil uji aktivitas antioksidan sediaan krim FI, FII, dan FIII menunjukkan persen aktivitas antioksidan berturut-turut sebesar 21,390%, 26,152%, dan 37,097%. Variasi konsentrasi ekstrak dalam formulasi sediaan krim memberikan pengaruh signifikan terhadap sifat fisika dan kimia krim.
ANALYSIS OF EFFECT OF MICROWAVE IRRADIATION IN FUNCTIONAL GROUP OF ZEOLITE SYNTHESIS
Authors: Suryani Puput Eka
Published: February 2022

Zeolite is a multifunctional material that is often used in industry as catalyst, ion exchange, adsorber, etc. Nowadays many researchers have studied and developed the synthesis technique of zeolite using new energy like microwave. Microwave irradiation has been shown to be more efficient when applied to chemical or physical processes. In this research will be studied the effect of microwave usage on zeolite characteristic that is produced by functional group at zeolite. Based on FTIR analysis on synthetic zeolite samples from rice husk ash using microwave irradiation modification, it can be concluded that the increase in absorbance occurs in samples with modification. This is evident in some functional groups such as Si-OH and Si-O-Al at wavelengths of 3450 cm-1 and 1000.35 cm-1. So it can be concluded that microwave irradiation can improve the reaction process in synthetic zeolite preparation.
PENERAPAN MESIN PENGADUK PADA UKM OLAHAN WALUH DI KECAMATAN GETASAN KABUPATEN SEMARANG
Authors: Sunyoto Sunyoto , Zahrulianingdyah Atiek , Rosidah Rosidah , Anisykulillah Indah
Published: February 2022

The aim of this activity is to solve the problems faced by SMEs engaged in processing pumpkin  as a superior product of Semarang Regency, Central Java. As an activity partner is UKM "KARUNA" led by Mrs. Nanik with the address of Getasan Village, Getasan District, Kab. Semarang. The main product of SME partners is geplak waluh (as snack). The process of making geplak waluh goes through several steps, and the most burdensome stage is the stirring process which takes a long time (8 hours) and is done manually. To overcome this problem, the implementation team has designed appropriate technology in the form of a geplak waluh mixer. The activity method includes several stages, including problem analysis, concept design, drawing work, component manufacturing, assembly, machine testing, and machine refinement. This activity has succeeded in implementing a geplak pumpkin mixer with 1 HP electric motor, 23.33 RPM stirring blade rotation, 24 kg production capacity, 5 hours cooking process. Thus the application of this machine can save 3 hours of time (37,5%), better product quality, more hygienic, and relieve workers
STUDI PERBANDINGAN SIFAT MEKANIK FIBERGLASS DAN KOMPOSIT SERAT RAMI BERMATRIKS EPOXY APLIKASI KAPAL PERIKANAN
Authors: Purnama Sari Ratih , Preston Siahaan Juniawan , Ziddin Hafiz , Bagus Prasetiyo Angger , Ilmal Yaqin Rizqi Ilmal Yaqin
Published: February 2022

Kapal perikanan di Indonesia umumnya menggunakan kayu sebagai bahan utamanya. Selain kayu bahan yang digunakan untuk pembuatan kapal perikanan yaitu komposit fiberglass. Namun, harga dari bahan komposit fiberglass sangat tinggi. Alternatif yang ditawarkan yaitu dengan pergantian matriks fiberglass dengan serat alam. Salah satu serat alam yang melimpah di Indonesia yaitu serat rami. Perbandingan sifat mekanik pada komposit fiberglass dan serat rami sangat perlu dipelajari. Pembuatan komposit fiberglass dan serat rami pada penelitian ini menggunakan metode hand lay up. Hasil yang didapatkan dari penelitian ini pada pengujian densitas yaitu pada kompoit fiberglass dan komposit serat rami secara berturut-turut yaitu 1,32 gr/cm3 dan 0,93 gr/cm3. Sedangkan pengujian kekerasan didapatkan nilai secara berturut-turut yaitu sebesar 73,23 shore D  dan 56,64 shore D. Pengujian tarik didapatkan nilai kekuatan tarik pada komposit fiberglass 138,65 MPa, sedangkan nilai kekuatan tarik komposit rami sebesar 25,17 MPa. Sedangkan elongansi komposit fiberglass yaitu 7,45% sedangkan komposit rami yaitu 0,54%. Hasil foto makro patahan pada komposit rami memiliki patahan tidak sempurna sedangkan komposit fiberglas memiliki patahan yang memperlihatkan patahan berpenguat tinggi.
EARLY DETECTION STRATEGY OF IMPLEMENTING HEALTH PROMOTION MODELS TOWARD CERVICAL CANCER EVENTS IN BRATI PUSKESMAS AREAS
Authors: Mahanani Mulyaningrum Festy , Lufianti Anita , Yuwanti Yuwanti
Published: February 2022

The incidence rate of cervical cancer in Central Java is 9.2%. Based on reports from health service agencies in Central Java, there were 7,029 cases in 2017 and in 2018 there were 7,029 cases. Early detection of cervical Ca with the IVA method in Central Java developed since 2007 the incidence of cervical cancer can be reduced by early detection. The purpose of this study was to determine the extent of the influence of health promotion, husband's support and information sources on early detection of cervical cancer, as well as the effective and relative contributions. This type of research uses quantitative research with a cross sectional approach, while the sampling technique is saturated sampling (census) where all members of the population are used as the research sample. The results of this study indicate a significant relationship between husband's support, health promotion, counseling with early detection of cervical cancer.
EVALUASI KEMAMPUAN PENAMPANG SUNGAI NGARENG SEBAGAI SALURAN DRAINASE PRIMER DALAM MENAMPUNG DEBIT AKIBAT CURAH HUJAN
Authors: Hariyanto Hariyanto , Maresti Eka
Published: February 2022

Jalan Ngareng merupakan kawasan permukiman padat penduduk dan pertokoan yang terletak di bagian utara Kecamatan Cepu, Kabupaten Blora. Kondisi geografis wilayah Ngareng yang lebih rendah bila dibandingkan dengan daerah di sekitarnya, meluapnya sungai Ngareng menjadikan wilayah ini menjadi salah satu titik langganan banjir di musim penghujan. Metode analisis data yaitu Normal, Gumbel, Log Normal, dan Log Pearson Type III. Berdasarkan empat metode yang diterapkan metode Gumbel paling mendekati persyaratan. Berdasarkan hasil analisa dan perhitungan, Sungai Ngareng tidak dapat menampung debit rencana  kala ulang 10 tahun  intensitas 62,388 mm/jam. Pada Sta 0+0 debit eksisting sungai sebesar 66,44 m3/detik, debit rencananya sebesar 191,845 m3/detik. Pada Sta 0+37,8 debit eksisting sungai sebesar 12,00 m3/detik, debit rencananya sebesar 94,519 m3/detik. Pada Sta 0+94,4 debit eksisting sungai sebesar 26,62 m3/detik, debit rencananya sebesar 180,615 m3/detik. Pada Sta 0+156,4 debit eksisting sungai sebesar 21,55m3/detik, debit rencananya sebesar 122,126 m3/detik. Pada Sta 0+218, debit eksisting sungai sebesar 32,88 m3/detik, debit rencananya sebesar 89,372 m3/detik. Dari hasil perhitungan, debit eksisting Sungai Ngareng lebih kecil dibandingkan debit rencana berakibat terjadi luapan.
DESAIN VIRTUAL TOUR BANGUNAN BERSEJARAH LAWANG SEWU SEMARANG MENGGUNAKAN APLIKASI AUGMENTED REALITY BERBASIS WEB (WEBAR)
Authors: Wibisono Arif , Indriari Wardhani Theodora
Published: February 2022

Perkembangan teknologi Augmented Reality (AR) merubah batas dan memperluas dunia visual kita, AR memiliki kelebihan bersifat interaktif dan real time sebagai media komunikasi visual. Disisi lain pemanfaatan teknologi ini mulai jamak digunakan di berbagai bidang, pada penelitian kali ini peneliti mencoba mengaplikasikan teknologi ini untuk tujuan memperkenalkan obyek wisata bersejarah Lawang Sewu di Kota Semarang diangkat sebagai obyek visual yang akan ditampilkan menggunakan teknologi AR. Memperkenalkan obyek visual menggunakan teknologi AR sendiri bukan hal yang baru, sudah banyak dilakukan di luar negeri, misal di China oleh Yi Ji, et al dari Guangdong University of Technologi Guangzhou, China, (2019). Yang menggunakan teknologi Augmented Reality Berbasis Web (WebAR) untuk mengenalkan kerajinan tangan tradisional (handycraft) dan cara pembuatannya, sebagai materi visualnya. Teknologi AR berbasis web dipilih, mengingat teknologi ini relatif baru, mudah diaplikasikan dan dapat berjalan lintas platform dan yang terakhir karena alasan perkembangan teknologi komunikasi, khususnya 5G didunia, dan peneliti meyakini teknologi ini akan menjadi tren kedepannya. Hasil penelitian menunjukkan aplikasi virtual tour menggunakan AR berbasis web ini mudah dikembangkan, sedangkan dari hasil pengujian menunjukkan aplikasi dapat berjalan dengan baik dengan metode pemindaian vertikal maupun horisontal, dan hasil pengujian menggunakan usability test dengan melibatkan 27 responden menunjukkan sebanyak 91,53% responden setuju bahwa aplikasi mudah digunakan, 94,18% responden setuju bahwa informasi visual dapat dilihat dengan jelas, 93,65% reponden berpendapat bahwa informasi visual yang ditampilkan mudah diingat 96,83 responden menikmati menggunakan aplikasi untuk mempelajari obyek bangunan bersejarah lawang sewu dan 96,83% responden tertarik untuk untuk menggunakan aplikasi ini kembali nantinya untuk obyek virtual yang lain. Sehingga peneliti menyimpulkan bahwa aplikasi virtual tour bisa dikembangkan menggunakan AR berbasis web dan menyarankan penggunaannya secara luas untuk virtual tour obyek visual yang lain.
ANALISIS PENERIMAAN SISTEM INFORMASI MANAJEMEN KEPEGAWAIAN PADA BADAN KEPEGAWAIAN, PENDIDIKAN DAN PELATIHAN (BKPP) KABUPATEN PULANG PISAU MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM)
Authors: Bhaswara Siwi Dyan Bentar , Wahyu Koko , Kartikasari Meivi
Published: February 2022

SIMPEG BKPP Pulang Pisau adalah sebuah sistem informasi manajemen kepegaian yang terdapat pada unit kerja BKPP dan digunakan oleh seluruh staf pada lingkungan pemerintahan Kabupaten Pulang Pisau, Kalimantan Tengah. Tujuan dari penelitian ini untuk menganalisa tingkat penerimaan pengguna terhadap SIMPEG BKPP Pulang Pisau. Teknik Analisa yang digunakan pada penelitian ini adalah teknik analisa jalur menggunakan model Technology Acceptance Model (TAM). Konsep TAM memiliki lima konstruk diantaranya adalah Perceived Ease of Use (PEOU), Perceived Usefulness (PU), Attitude Toward Using (ATU), Behavioral Intention to Use (ITU), dan Actual System Usage (ASU). Jenis data yang digunakan adalah data primer yang telah didapatkan melalui kuesioner. Jenis pengambilan sampel yang digunakan adalah Quota sampling dimana jumlah responden yang digunakan telah ditetapkan menggunakan rumus Slovin sejumlah 100 orang pengguna SIMPEG di BKPP Pulang Pisau. Hasil dari penelitian ini menunjukan bahwa dari segi persepsi kemudahan penggunaan, persepsi kemanfaatan, sikap penggunaan sistem, kondisi nyata penggunaan sistem SIMPEG BKPP Pulang Pisau sudah diterima dengan nilai p-values diatas 0,05 dan satu variabel yang ditolak dari segi kecenderungan perilaku untuk tetap menggunakan karena memilik nilai p-values dibawah 0,05.
RANCANG BANGUN ALAT PENGERING BAHAN MAKANAN BERBASIS WINGS DRYING SYSTEM DENGAN DUA SUMBER PANAS
Authors: Puswadi Hendri Aldi , Sunyoto Sunyoto
Published: February 2022

Permasalahan umum alat pengering yaitu penyebaran udara panas tidak merata. Tujuan penelitian untuk mendesain, mengetahui kefeektifan, dan menganalisis efisiensi alat. Penelitian menggunakan model pengembangan ADDIE (Analyze, Design, Develop, Implement, dan Evaluate). Teknik analisis data yang digunakan adalah statistik deskriptif. Hasil penelitian menunjukkan desain alat pengering dapat menyebarkan udara panas merata. Keefektifan menggunakan LPG (Liquid Petroleum Gas) maupun listrik menunjukkan hasil akhir kadar air bahan yaitu 10%. Efisiensi waktu menggunakan LPG pada suhu 40⁰C, 50⁰C, dan 60⁰C membutuhkan waktu 150 menit, 75 menit, dan 65 menit dengan efisiensi biaya produksi besarnya Rp. 4.900,00; Rp. 7.000,00; dan Rp. 7.700,00. Efisiensi waktu menggunakan listrik pada suhu 40⁰C, 50⁰C, dan 60⁰C membutuhkan waktu 210 menit, 180 menit, dan 165 menit dengan efisiensi biaya produksi besarnya Rp. 2.567,70; Rp. 2.200,90; dan Rp. 2.017,50. Waktu pengeringan paling efisien dengan LPG yaitu 65 menit pada suhu 60⁰C dan biaya produksi paling efisien dengan listrik yaitu Rp. 2.017,50 pada suhu 60⁰C.
ISOLASI ENZIM AMILASE DARI KECAMBAH KACANG TUNGGAK (Vigna unguiculata)
Authors: Pratantie Elvina Maitri , Bintoro V. Priyo , Dwiloka Bambang
Published: February 2022

Enzim amilase merupakan enzim yang berperan dalam proses pencernaan. Enzim amilase terdapat pada kecambah dari kacang-kacangan seperti kacang tunggak. Kacang tunggak merupakan salah satu jenis tanaman kacang-kacangan yang memiliki sumber protein nabati yang tinggi serta memiliki jumlah yang melimpah di Indonesia. Penelitian bertujuan untuk mengetahui pengaruh konsentrasi garam amonium sulfat dan lama inkubasi perkecambahan kacang tunggak yang optimal terhadap aktivitas enzim amilase. Penelitian dengan lama inkubasi perkecambahan kacang tunggak yang terdiri dari lima tingkatan yaitu 24 jam, 30 jam, 36 jam, 42 jam, dan 48 jam. Berdasarkan uji statistik yang dilakukan lama perkecambahan 24 jam menghasilkan aktifitas amilase 6,20±0,62 Unit/mL, protein 132,09±1,86 mg/mL, aktifitas spesifik 0,047±0,004 Unit/mg, dan pH 6,08±0,10; 30 jam menghasilkan aktifitas amilase 5,67±0,26 Unit/mL, protein 103,93±2,32 mg/mL, aktifitas spesifik 0,055±0,002 Unit/mg, dan pH 6,15±0,10; 36 jam menghasilkan aktifitas amilase 5,79±0,38 Unit/mL, protein 72,19±1,34 mg/mL, aktifitas spesifik 0,080±0,004 Unit/mg, dan pH 6,33±0,05; 42 jam menghasilkan aktifitas amilase 3,11±0,28 Unit/mL, protein 75,31±2,53 mg/mL, aktifitas spesifik 0,041±0,004 Unit/mg, dan pH 6,15±0,10; dan 48 jam menghasilkan aktifitas amilase 5,98±1,11 Unit/mL, protein 112,60±7,07 mg/mL, aktifitas spesifik 0,054±0,013 Unit/mg, dan pH 6,03±0,10. Hasil perkecambahan 36 jam menghasilkan aktifitas spesifik terbanyak.