bluuebunny/crossref_metadata_2025 huggingface dataset:
Surface state tunable energy and mass renormalization from homothetic quantum dot arrays
Authors: Piquero-Zulaica Ignacio , Li Jun , Abd El-Fattah Zakaria M. , Solianyk Leonid , Gallardo Iker , Monjas Leticia , Hirsch Anna K. H. , Arnau Andres , Ortega J. Enrique , Stöhr Meike , Lobo-Checa Jorge
Published: November 2019

The surface electronic structure is engineered by means of metal–organic networks. We show that on top of electron confinement phenomena, the energy of the state can be controlled via the adatom coordination density.
Amplified vibrational circular dichroism as a manifestation of the interaction between a water soluble gold nanocluster and cobalt salt
Authors: Roy Bhattacharya Sarita , Bürgi Thomas
Published: November 2019

Co2+ leads to the drastic enhancement of vibrational circular dichroism of a thiolate-protected gold cluster.
Synthesis and stereochemistry of helical polyurethanes based on 2,2′-dihydroxy-1,1′-binaphthyl and diisocyanatobenzenes
Authors: Dai Heshuang , Shichibu Yukatsu , Imai Yoshitane , Hara Nobuyuki , Konishi Katsuaki , Wang Yue , Song Zhiyi , Nakano Tamaki
Published: November 2019

Helical polyurethanes were prepared from 1,4- and 1,3-diisocyanatobenzene and BINOL having various e.e.'s where helix handedness was governed by absolute configuration of major enantiomer of BINOL.
Reversible helical polymerization of supramolecular toroidal objects
Authors: Shen Bowen , Lee Myongsoo
Published: November 2019

Reversible helical polymerization of toroids with rapid response to heating–cooling cycles and helicity control in the presence of a chiral regulator.
A facile approach to thermomechanically enhanced fatty acid-containing bioplastics using metal–ligand coordination
Authors: Lamm Meghan E. , Song Lingzhi , Wang Zhongkai , Lamm Benjamin , Fu Lin , Tang Chuanbing
Published: November 2019

Dynamic metal–ligand coordination creates physical crosslinking and thus improves chain entanglements for enhancing the thermomechanical properties of biobased polymers.
Rapid synthesis of MgCo2O4 and Mg2/3Ni4/3O2 nanocrystals in supercritical fluid for Mg-ion batteries
Authors: Truong Quang Duc , Kobayashi Hiroaki , Honma Itaru
Published: November 2019

High-quality spinel MgCo2O4 and rocksalt Mg2/3Ni4/3O2 nanocrystal cathodes allow fast extraction/insertion of magnesium ions for high energy-density batteries.
Corrosion inhibition of mild steel by the hydrolysate of an imidazoline-based inhibitor in CO2-saturated solution
Authors: Wang Bin , Du Min , Zhang Jing , Li Chengjie , Liu Jie , Liu Huanxia , Li Rongrong , Li Zhuoran
Published: November 2019

The hydrolysate of an imidazoline-based inhibitor was characterized and tested, which can efficiently protect Q235 steel against CO2 corrosion.
Application of smectite for textile dyeing and fastness improvement
Authors: Jung Jong Sun , Kim Seong Hun
Published: November 2019

A novel smectite post-treatment is developed for enhancement of both washing fastness and light fastness by simultaneous intercalation of pre-dyed cationic dyes.
Metagenomic ene-reductases for the bioreduction of sterically challenging enones
Authors: Dobrijevic Dragana , Benhamou Laure , Aliev Abil E. , Méndez-Sánchez Daniel , Dawson Natalie , Baud Damien , Tappertzhofen Nadine , Moody Thomas S. , Orengo Christine A. , Hailes Helen C. , Ward John M.
Published: November 2019

Exceptional organic solvent tolerant ene-reductases mined from a drain metagenome library are highly versatile catalysts for difficult enones.
Cu2−xSe nanoparticles (Cu2−xSe NPs) mediated neurotoxicityviaoxidative stress damage in PC-12 cells and BALB/c mice
Authors: Leng Faning , Liu Yali , Li Guobing , Lai Wenjing , Zhang Qian , Liu Wuyi , Hu Changpeng , Li Pantong , Sheng Fangfang , Huang Jingbin , Zhang Rong
Published: November 2019

Cu2−xSe nanoparticles (Cu2−xSe NPs) are widely used for optical diagnostic imaging and photothermal therapy due to their strong near-infrared (NIR) optical absorption.
Ultrasensitive detection of uric acid in serum of patients with gout by a new assay based on Pt@Ag nanoflowers
Authors: Wang Xue , Chen Shujun , Tang Xiaomin , Lin Daiqin , Qiu Ping
Published: November 2019

A ultrasensitive assay for the determination of uric acid (UA) based on Pt@Ag nanoflowers (Pt@Ag NFs) was constructed.
Recyclable functionalized polymer films for the efficient removal of hexavalent chromium from aqueous solutions
Authors: Liu Weikang , Wang Mei , Wen Zhigang , Li Zhong , Yang Liang , Jiang Changlong
Published: November 2019

A PEI-PVA functionalized composite film has been developed to remove hexavalent chromium ion Cr(vi) from water by an adsorption–reduction mechanism.
The fabrication of a Co3O4/graphene oxide (GO)/polyacrylonitrile (PAN) nanofiber membrane for the degradation of Orange II by advanced oxidation technology
Authors: Zhang Hao , Liu Weihua , Tian Feng , Tang Zhongfeng , Lin Haitao
Published: November 2019

Treating water that has been polluted with chemical dyes is an important task related to water resources.
Room-temperature phosphorescent polymers with excitation-wavelength and delay-time emission dependencies
Authors: Zou Linmin , Qin Xiaojin , Sun Huazhen , Wang Shiqi , Ding Wenwen , Liu Yuanli , Wei Chun , Jiang Bingli , Gong Yongyang
Published: November 2019

Poly(4-styrenesulfonic acid-co-maleic acid) salt ionomer was found to have excitation wavelength and delay time tunable RTP emission characteristics.
Preparative separation of seven phenolic acids from Xanthii Fructus using pH-zone-refining counter-current chromatography combined with semi-preparative high performance liquid chromatography
Authors: Ma Tianyu , Xu Lihua , Wang Xinming , Li Jia , Guo Lanping , Wang Xiao
Published: November 2019

Segmentation and purification strategy using pH-zone-refining counter-current chromatography combined with semi-preparative HPLC for separation of six caffeoylquinic acid isomers and a caffeic acid from Xanthii Fructus.
Iron oxide encapsulated by copper-apatite: an efficient magnetic nanocatalyst for N-arylation of imidazole with boronic acid
Authors: Amadine Othmane , Essamlali Younes , Amedlous Abdallah , Zahouily Mohamed
Published: November 2019

N-Arylation of imidazole with various arylboronic acids was carried out using Fe3O4@Cu-apatite nanocatalyst with good to excellent yields.
5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis
Authors: Zhang Qian , Fu Ying , Zhao Yufan , Cui Shanshan , Wang Jing , Liu Fengxi , Yuan Yuan , Galons Hervé , Yu Peng , Teng Yuou
Published: November 2019

5-Acetamido-1-(methoxybenzyl) isatin inhibited the proliferation, migration, and angiogenesis of several tumor cell linesin vitro.
Air-assisted ionic liquid dispersive liquid–liquid microextraction based on solidification of the aqueous phase for the determination of triazole fungicides in water samples by high-performance liquid chromatography
Authors: Jia Liyan , Yang Jingrui , Zhao Wenfei , Jing Xu
Published: November 2019

A simple, rapid, and environmentally friendly approach was introduced to determine triazole fungicides in water samples by air-assisted ionic liquid dispersive liquid–liquid microextraction based on solidification of the aqueous phase by HPLC-DAD.
Nanostructured carbons containing FeNi/NiFe2O4 supported over N-doped carbon nanofibers for oxygen reduction and evolution reactions
Authors: Aziz Iram , Lee JinGoo , Duran Hatice , Kirchhoff Katrin , Baker Richard T. , Irvine John T. S. , Arshad Salman N.
Published: November 2019

Non-precious metal-based electrocatalysts on carbon materials with high durability and low cost have been developed to ameliorate the oxygen-reduction reaction (ORR) and oxygen-evolution reaction (OER).
Low-temperature selective catalytic reduction of NOx with NH3 over an activated carbon-carbon nanotube composite material prepared by in situ method
Authors: Wang Pengchen , Yao Lu , Pu Yijuan , Yang Lin , Jiang Xia , Jiang Wenju
Published: November 2019

A Ce-supported activated carbon-carbon nanotube composite (Ce/AC-CNTs) catalyst was prepared by in situ formation of CNTs on AC and then modified by Ce, and was subsequently used for low-temperature selective catalytic reduction of NOx with NH3.
Synthesis of amino acids and peptides with bulky side chains via ligand-enabled carboxylate-directed γ-C(sp3)–H arylation
Authors: Liu Lei , Liu Yan-Hua , Shi Bing-Feng
Published: November 2019

Pd-catalyzed ligand-enabled γ-C(sp3)–H arylation of tert-leucine and its derived peptides without using an external directing group via a less favored six-membered palladacycle is reported.
Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?
Authors: Sponchioni M. , O'Brien C. T. , Borchers C. , Wang E. , Rivolta M. N. , Penfold N. J. W. , Canton I. , Armes S. P.
Published: November 2019

It is shown that hydroxyl functionality is required to induce stasis in human embryonic stem cell colonies immersed within wholly synthetic block copolymer worm gels with comparable storage moduli. Thus gel softness does not appear to be an essential parameter for stasis induction.
Uncatalyzed conjugate addition of organozinc halides to enones in DME: a combined experimental/computational study on the role of the solvent and the reaction mechanism
Authors: Casotti Gianluca , Ciancaleoni Gianluca , Lipparini Filippo , Nieri Chiara , Iuliano Anna
Published: November 2019

The reaction mechanism of a new conjugate addition reaction of organozinc halides to enones is disclosed by a combined experimental/computational study.
An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging
Authors: Xu Yan , Yang Weitao , Yao Defan , Bian Kexin , Zeng Weiwei , Liu Kai , Wang Dengbin , Zhang Bingbo
Published: November 2019

An aggregation-induced emission (AIE) dye-powered afterglow luminogen has been designed for in vivo tumor imaging. The underlying afterglow mechanism can be described as a closed-loop of “photon–1O2–SP intermediates–photon”.
Boron-doped graphene-supported manganese oxide nanotubes as an efficient non-metal catalyst for the oxygen reduction reaction
Authors: Sookhakian M. , Ullah Habib , Mat Teridi Mohd Asri , Tong Goh Boon , Basirun W. J. , Alias Y.
Published: November 2019

An efficient, low cost and non-precious hybrid metal catalyst compound consisting of boron-doped graphene nanosheets (BGNSs) and manganese oxide (MnO2) nanotubes is used as a catalyst for the oxygen reduction reaction (ORR).
First principles calculations study of α-MnO2as a potential cathode for Al-ion battery application
Authors: Alfaruqi Muhammad Hilmy , Islam Saiful , Lee Jun , Jo Jeonggeun , Mathew Vinod , Kim Jaekook
Published: November 2019

Theoretical studies based on density functional theory of α-MnO2as a potential cathode for Al-ion battery are presented.
Light enhanced moisture degradation of perovskite solar cell material CH3NH3PbI3
Authors: Lu Ying-Bo , Cong Wei-Yan , Guan ChengBo , Sun Hui , Xin Yanqing , Wang Kunlun , Song Shumei
Published: November 2019

We reveal the relationship between the light enhanced moisture degradation and the photostriction effect in MAPbI3 perovskite.
A visible-light-responsive metal–organic framework for highly efficient and selective photocatalytic oxidation of amines and reduction of nitroaromatics
Authors: Chen Peiqi , Guo Zhifen , Liu Xin , Lv Hui , Che Yan , Bai Rong , Chi Yanhong , Xing Hongzhu
Published: November 2019

A novel visible-light-responsive metal–organic framework for highly efficient and selective transformation of amines and nitroaromatics to produce imines and anilines.
CAPRYDAA, an anthracene dye analog to LAURDAN: a comparative study using cuvette and microscopy
Authors: Castro-Castillo Vicente , Gajardo Javier , Sandoval-Altamirano Catalina , Gratton Enrico , Sanchez Susana , Malacrida Leonel , Gunther German
Published: November 2019

We synthesized an anthracene derivative with solvatochromic properties to be used as a molecular probe for membrane dynamics and supramolecular organization.
Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy
Authors: Veloso Sérgio R. S. , Martins J. A. , Hilliou Loic , O. Amorim C. , Amaral V. S. , Almeida B. G. , Jervis Peter J. , Moreira Rute , Pereira David M. , Coutinho Paulo J. G. , Ferreira Paula M. T. , Castanheira Elisabete M. S.
Published: November 2019

Supramolecular plasmonic magnetogels comprising two different nanoparticle architectures were developed and evaluated as potential nanocarriers for multimodal cancer therapy with reversible photothermia capabilities and tuneable drug release.
Self-quenching synthesis of coordination polymer pre-drug nanoparticles for selective photodynamic therapy
Authors: Song Yucong , Li Yite , Zhang Yuandong , Wang Lei , Xie Zhigang
Published: November 2019

A novel “pre-photodynamic” nanoparticles (Fe-IBDP NPs) with a tumor microenvironment (TME)-activatable PDT and good biodegradability were synthesized by self-quenching strategy.
Solution viscosity regulates chondrocyte proliferation and phenotype during 3D culture
Authors: Lee Kyubae , Chen Yazhou , Li Xiaomeng , Wang Yongtao , Kawazoe Naoki , Yang Yingnan , Chen Guoping
Published: November 2019

Chondrocytes are cultured in a 3D biphasic gelatin solution/hydrogel system. Solution viscosity affects chondrocyte functions. High viscosity is more beneficial for cell phenotype maintenance, while low viscosity is more beneficial for proliferation.
Synthesis, characterization, and hole-transporting properties of benzotriazatruxene derivatives
Authors: Chooppawa Tianchai , Namuangruk Supawadee , Yamamoto Hiroshi M. , Promarak Vinich , Rashatasakhon Paitoon
Published: November 2019

Four derivatives of benzotriazatruxene are synthesized and tested as hole-transporting materials in organic field-effect transistors and organic light-emitting diodes.
Biomimetics for high-performance flexible tactile sensors and advanced artificial sensory systems
Authors: Amoli Vipin , Kim So Young , Kim Joo Sung , Choi Hanbin , Koo Jehyoung , Kim Do Hwan
Published: November 2019

Artificial smart designs inspired by structural and functional features of biological organisms have opened new avenues to develop high-performance flexible tactile sensors and advanced artificial sensory systems.
Au-covered hollow urchin-like ZnO nanostructures for surface-enhanced Raman scattering sensing
Authors: Graniel Octavio , Iatsunskyi Igor , Coy Emerson , Humbert Christophe , Barbillon Grégory , Michel Thierry , Maurin David , Balme Sébastien , Miele Philippe , Bechelany Mikhael
Published: November 2019

Au-covered hollow urchin-like ZnO nanostructures were prepared with controlled size by combining nanosphere lithography (NSL), atomic layer deposition (ALD), electrodeposition, and electron beam (e-beam) evaporation.
Endoplasmic reticulum Ca2+ release causes Rieske iron–sulfur protein-mediated mitochondrial ROS generation in pulmonary artery smooth muscle cells
Authors: Dong Dapeng , Hao Qiongyu , Zhang Ping , Wang Tao , Han Fei , Liang Xiaodong , Fei Zhenghua
Published: November 2019

Mitochondrial reactive oxygen species (ROS) cause Ca2+ release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role in hypoxic pulmonary vasoconstriction (HPV). Here we tested a novel hypothesis that hypoxia-induced RyR-mediated Ca2+ release may, in turn, promote mitochondrial ROS generation contributing to hypoxic cellular responses in PASMCs. Our data reveal that application of caffeine to elevate intracellular Ca2+ concentration ([Ca2+]i) by activating RyRs results in a significant increase in ROS production in cytosol and mitochondria of PASMCs. Norepinephrine to increase [Ca2+]i due to the opening of inositol 1,4,5-triphosphate receptors (IP3Rs) produces similar effects. Exogenous Ca2+ significantly increases mitochondrial-derived ROS generation as well. Ru360 also inhibits the hypoxic ROS production. The RyR antagonist tetracaine or RyR2 gene knockout (KO) suppresses hypoxia-induced responses as well. Inhibition of mitochondrial Ca2+ uptake with Ru360 eliminates N- and Ca2+-induced responses. RISP KD abolishes the hypoxia-induced ROS production in mitochondria of PASMCs. Rieske iron–sulfur protein (RISP) gene knockdown (KD) blocks caffeine- or NE-induced ROS production. Taken together, these findings have further demonstrated that ER Ca2+ release causes mitochondrial Ca2+ uptake and RISP-mediated ROS production; this novel local ER/mitochondrion communication-elicited, Ca2+-mediated, RISP-dependent ROS production may play a significant role in hypoxic cellular responses in PASMCs.
Comprehensive assessment of the association between XPC rs2228000 and cancer susceptibility based on 26835 cancer cases and 37069 controls
Authors: Dai Yingqi , Song Zhonghua , Zhang Jinqing , Gao Wei
Published: November 2019

Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer.

Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P-value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated.

Results We selected a total of 71 eligible studies with 26835 cancer cases and 37069 controls from the 1186 retrieved articles. There is an enhanced susceptibility for bladder cancer cases under T vs. C [P=0.004; OR (95% CI) = 1.25 (1.07, 1.45)], TT vs. CC [P=0.001; 1.68 (1.25, 2.26)], CT+TT vs. CC [P=0.016; 1.26 (1.04, 1.53)], and TT vs. CC+ CT [P=0.001; 1.49 (1.18, 1.90)] compared with negative controls. Additionally, there is an increased risk of breast cancer under T vs. C, TT vs. CC and TT vs. CC+ CT (P<0.05, OR > 1). Nevertheless, there is a decreased risk of gastric cancer cases in China under T vs. C [P=0.020; 0.92 (0.85, 0.99)], CT vs. CC [P=0.001, 0.83 (0.73, 0.93)], and CT+TT vs. CC [P=0.003, 0.84 (0.76, 0.94)].

Conclusions The TT genotype of XPC rs2228000 may be linked to an increased risk of bladder and breast cancer, whereas the CT genotype is likely to be associated with reduced susceptibility to gastric cancer in the Chinese population.
Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms
Authors: Ji Yong-Zhi , Liu Shi-Rui
Published: November 2019

Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.
Features of reflection of electromagnetic waves from nanometric perforated multilayers including epsilon-near-zero metamaterials
Authors: Starodubtsev Evgenii
Published: November 2019

Using the exact solutions of electromagnetic boundary problems, analytical modeling of reflection of electromagnetic waves from nanometric perforated multilayers has been carried out. New features of operation of the multilayers including the substrate or layers of epsilon-near-zero (ENZ) materials are established. Presence of the ENZ main layer or substrate leads to the quickly changing and extreme values of phase and module of amplitude reflection coefficients depending on the system parameters. The ENZ (or metallic for the thicker systems) substrate has a significant impact on the transformation of phase difference of the reflected waves. The detailed numerical analysis of the obtained results for the multilayers including silver or phase change materials (germanium antimony tellurium alloy, vanadium dioxide) components is performed. The considered reflection characteristics are reasonably “stable” to variation of the system parameters such as oblique incidence of the exciting radiation (for TE or TM polarization), possible presence of magnetic properties of the layers and effective electromagnetic anisotropy of the substrate material. The obtained results can be used to develop ultra-thin (with significantly subwavelength thicknesses) transformers of phase and amplitude of reflected radiation, holograms, metasurfaces and other nanophotonics applications.
Enhancement of inductance along metallic mesh wires in three-dimensional quasi-isotropic metamaterials using high-ε dielectric particles for impedance-matching with free space
Authors: Yamaguchi Takuya , Ishiyama Takumi , Ueda Tetsuya , Itoh Tatsuo
Published: November 2019

In this paper, we consider cube-shaped unit cells including high-ε dielectric cubes under magnetic dipole-like resonance placed at the center and metallic mesh wires for negative permittivity to construct three-dimensional quasi-isotropic metamaterials in the microwave region. Basically, such structures suffer from their low wave impedance due to inclusion of high-ε materials. To reduce effective permittivity of the composite structures, we propose to insert additional inductance into the metallic mesh. For the insertion of lumped inductors along the wires, dispersion diagram and the Bloch-impedance are numerically estimated, and converted to effective permittivity and permeability. The numerical simulation results clearly show almost 3-D isotropic propagation characteristics in a specific frequency region and enhancement of the Bloch-impedance close to free space in the left-handed region. The lumped inductors are replaced by meander-line strip patterns for practical configurations. The metallic patterned structures also achieve the enhanced Bloch impedance that is well-matched to free space.
Research on the oxygen content in 304L stainless steel during VOD-LF-CC process based on IMCT
Authors: Chen Xingrun , Cheng Guoguang , Li Yao , Hou Yuyang
Published: November 2019

The total oxygen in 304L stainless steel produced by the VOD-LF-CC process is investigated in this research. The equilibrium oxygen content in the molten steel during the smelting process is calculated based on the ion-molecule coexistence theory. The results show that it is feasible to use the developed thermodynamic model for calculating the equilibrium oxygen content in CaO–SiO2–Al2O3–MgO–FeO–Cr2O3 slags equilibrated with 304L molten steel. The variation law for total oxygen is in good agreement with the equilibrium oxygen content. The oxygen content of the oxide-inclusion decreases with the number density of inclusions, which decrease at different stages in the process. The content of FeO and Cr2O3 in the slag has no obvious effect on the equilibrium oxygen content when the basicity of the slag remains constant. Combining the proposed method with industrial practice, the optimum VOD process parameters for obtaining a low equilibrium oxygen content are as follows: 1600–1650 °C of the temperature after the VOD stage, 0.4–0.5% of the Si content after reduction, and 2.2–2.5 of the slag basicity.
Phytotherapie von Bisswunden in der Tiermedizin
Authors: Brendieck-Worm Cäcilia
Published: November 2019

Wunden zählen zu den häufigen Vorstellungsgründen in der tierärztlichen Praxis. Vielfach handelt es sich um Bissverletzungen, die durch Artgenossen verursacht wurden und die durch die Mundhöhlenflora des Aggressors per se als infiziert eingestuft werden müssen.
Laparoskopische Hemihepatektomie links mit intraoperativer Indocyaningrün-Perfusionsbildgebung
Authors: Sucher Robert , Rademacher Sebastian , Lederer Andri , Hau Hans-Michael , Petersen Tim Ole , Seehofer Daniel
Published: November 2019

Die intraoperative Indocyaningrün-Perfusionsbildgebung (ICG-Perfusionsbildgebung) ermöglicht eine genaue Identifikation von Lebersegmenten und Resektionsebenen, welche für die anatomische Leberresektion von Bedeutung sind. Wir berichten über einen 54-jährigen Patienten, bei dem aufgrund von rezidivierenden Cholangitiden bei Caroli-Erkrankung eine laparoskopische Hemihepatektomie links durchgeführt wurde. Zur Identifikation der exakten anatomischen Resektionslinie wurde dem Patienten nach Klemmen der linken Leberarterie und des linken Pfortaderastes intravenös ICG verabfolgt. Während der Parenchymdurchtrennung wurde die Leber im Normalweißlicht und Nahinfrarotlicht (NIR) untersucht. Diese Technik ermöglichte eine präzise anatomische Resektion der nicht perfundierten Lebersegmente 2, 3 und 4.
Lower GI Bleeding: An Update on Incidences and Causes
Authors: Adegboyega Titilayo , Rivadeneira David
Published: November 2019

Bleeding from the lower gastrointestinal tract represents a significant source of morbidity and mortality. The colon represents the vast majority of the location of bleeding with only a much smaller incidence occurring in the small intestine. The major causes of lower gastrointestinal bleeding (LGIB) are from diverticulosis, vascular malformations, and cancer. We discuss the incidence and causes of LGIB.
Digitalisierung: Wir leben in interessanten Zeiten
Authors: Gocke Peter
Published: November 2019

November ist Medica-Zeit.
Aktuelle Studie: Krankenkassen droht Milliardendefizit
Authors: Ehrhardt-Joswig Jana
Published: November 2019

Eine aktuelle Studie des Iges-Instituts im Auftrag der Bertelsmann Stiftung prognostiziert für die Gesetzliche Krankenversicherung (GKV) bis zum Jahr 2040 ein Defizit von 50 Milliarden Euro. Dr. Stefan Etgeton, Senior Expert bei Bertelsmann, erläutert im kma-Interview, wie es dazu kommt und warum die Gesundheitspolitik allein dagegen nichts ausrichten kann.
Klinikunternehmen: Auf-/Absteiger des Monats
Authors: Schmidt Hartmut
Published: November 2019

Börsenexperte Hartmut Schmidt analysiert für kma die Jahresabschlüsse ausgewählter Kliniken
Editorial: Dauerbrenner Digitalisierung
Authors: Ehrhardt-Joswig Jana
Published: November 2019

Die verstärkte Digitalisierung von Prozessen in der Gesundheitswirtschaft ist seit Jahren Topthema bei der Medica.
Integration Bildgebender Verfahren in Die Klinische IT: Prozesshaft denken und handeln
Authors: Buchholz Ralf
Published: November 2019

Die bildgebende Diagnostik boomt in deutschen Krankenhäusern. In den vergangenen zehn Jahren hat sich die Zahl der Untersuchungen mehr als verdoppelt. Die Herausforderung besteht darin, die erstellten Bilder in die vorhandenen IT-Systeme zu integrieren und sie so dem klinikweiten Workflow zur Verfügung zu stellen.
Numerical study of an unsteady flow of thixotropic liquids past a cylinder
Authors: Bui Cuong Mai , Ho Thinh Xuan
Published: November 2019

This paper presents a numerical study of a complex fluid flow past a circular cylinder. The fluid is a thixotropic viscoplastic material. Thixotropy is a time-dependent rheological property associated with the material’s microstructure, which can be broken and/or built up during a flowing process. It is modeled using a structural parameter representing the structural state, which can vary from being completely broken to fully structured. Effects of the thixotropic parameters controlling the rate of the structural breakdown and recovery processes on the flow characteristics are investigated. Either the Herschel–Bulkley model or the Bingham model is employed together with Papanastasiou’s regularization scheme. A review on the determination of the regularization parameter is carried out; a new approach to this is thus proposed. Various flow aspects such as the unyielded/rigid zones, the structural evolution, and the vortex structures are analyzed. Results show that at Re = 150 and Bn ≤ 5, the flow is nonstationary with periodic vortex shedding. The structural state is found to correlate well with the vortex structures. A full structural recovery can happen either within or beyond the yield boundary, or even beyond the computational domain. Moreover, the drag coefficient is reported and discussed.
Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat
Authors: Yao Xiaolei , Wang Zhibo , El-Samahy M. A. , Ren Caifang , Liu Zifei , Wang Feng , You Peihua
Published: November 2019

The objective of this study was to investigate the dose-dependent effect of 1α,25-(OH)2VD3 (Vit D3) on invitro proliferation of goat luteinised granulosa cells (LGCs) and to determine the underlying mechanisms of its action by overexpressing and silencing vitamin D receptor (VDR) in LGCs. Results showed that VDR was prominently localised in GCs and theca cells (TCs) and its expression increased with follicle diameter, but was lower in atretic follicles than in healthy follicles. The proliferation rate of LGCs was significantly higher in the Vit D3-treated groups than in the control group, with the highest proliferation rate observed in the 10nM group; this was accompanied by changes in the expression of cell cycle-related genes. These data indicate that Vit D3 affects LGC proliferation in a dose-dependent manner. Contrary to the VDR knockdown effects, its overexpression upregulated and downregulated cell cycle- and apoptosis-related genes respectively; moreover, supplementation with 10nM of Vit D3 significantly enhanced these effects. These results suggest that changes in VDR expression patterns in LGCs may be associated with follicular development by regulation of cell proliferation and apoptosis. These findings will enhance the understanding of the roles of Vit D3 and VDR in goat ovarian follicular development.
The process to rapprochement between Vietnam and its diaspora in the United States
Authors: Hanh Nguyen Nguyen Le
Published: November 2019

Despite the lingering conflict between the government of Vietnam and the Vietnamese diaspora in the United States, issues of remittance and relationship relaxation between the refugees and Vietnamese government happened both in the 1990s. Recent years have seen the attitude-change of the returning diaspora and their shifting strategies of working in Vietnam. This paper describes the first step toward rapprochement between Vietnam and its diaspora in the United States, by analysing the attempts of Vietnam to approach its diaspora in the United States and the reactions of the diasporic community members. On the other hand, it also describes the efforts of Vietnamese Americans to empower Vietnamese people through philanthropic and civic engagement activities. The rapprochement via media and civic engagement reveals a shift from hard, intense ideological conflict to soft tactics in the transnational relation between Vietnam and the Vietnamese diaspora in the United States. This paper concludes that the process to rapprochement is still challenged by the significant differences in political views between the two sides. It suggests that the process of negotiation and conflict resolution be conducted with openness, honesty and acceptance of differences.
Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases
Authors: Pandey Nootan , Keifenheim Daniel , Yoshida Makoto Michael , Hassebroek Victoria A. , Soroka Caitlin , Azuma Yoshiaki , Clarke Duncan J.
Published: November 2019

Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay anaphase onset when Topo II is perturbed, providing additional time for decatenation. Molecular insight into this checkpoint is lacking. Here we present evidence that catalytic inhibition of Topo II, which activates the checkpoint, leads to SUMOylation of the Topo II C-terminal domain (CTD). This modification triggers mobilization of Aurora B kinase from inner centromeres to kinetochore proximal centromeres and the core of chromosome arms. Aurora B recruitment accompanies histone H3 threonine-3 phosphorylation and requires Haspin kinase. Strikingly, activation of the checkpoint depends both on Haspin and Aurora B. Moreover, mutation of the conserved CTD SUMOylation sites perturbs Aurora B recruitment and checkpoint activation. The data indicate that SUMOylated Topo II recruits Aurora B to ectopic sites, constituting the molecular trigger of the metaphase checkpoint when Topo II is catalytically inhibited.
Estimation of plasma equilibrium parameters via a neural network approach*
Authors: Zhu Zi-Jian , Guo Yong , Yang Fei , Xiao Bing-Jia , Li Jian-Gang
Published: November 2019

Plasma equilibrium parameters such as position, X-point, internal inductance, and poloidal beta are essential information for efficient and safe operation of tokamak. In this work, the artificial neural network is used to establish a non-linear relationship between the measured diagnostic signals and selected equilibrium parameters. The estimation process is split into a preliminary classification of the kind of equilibrium (limiter or divertor) and subsequent inference of the equilibrium parameters. The training and testing datasets are generated by the tokamak simulation code (TSC), which has been benchmarked with the EAST experimental data. The noise immunity of the inference model is tested. Adding noise to model inputs during training process is proved to have a certain ability for maintaining performance.
Investigation on dry machining of stainless steel 316 using textured tungsten carbide tools
Authors: Mashinini P M , Soni Hargovind , Gupta Kapil
Published: November 2019

In this research, austenitic stainless steel SS316 material has been machined using textured carbide cutting tools under dry conditions. Micro-textures were made on tool rake face using wire spark erosion machining technology. Effects of three important machining process parameters i.e. cutting speed, depth of cut and feed rate on machinability (MRR, average roughness, and tool wear) of SS316 have been investigated. Taguchi L27 orthogonal array based twenty seven experiments have been carried out by varying machining parameters at three levels. Feed rate has been identified as the most important parameter. Machining parameters have been optimized by grey entropy method to enhance the machinability. Optimal combination of machining parameters i.e. 170 m min−1 cutting speed, 0.5 mm/rev feed rate and 1.5 mm depth of cut produced the best machinability with 3.436 μm average roughness, 105187 mm3 min−1. MRR, and tool wear 234.63 μm. Lastly, a tool wear and chip morphology study have been done where textured tools have been found outperformed plain (Non-textured) tools.
Quantum technologies in Russia
Authors: Fedorov A K , Akimov A V , Biamonte J D , Kavokin A V , Khalili F Ya , Kiktenko E O , Kolachevsky N N , Kurochkin Y V , Lvovsky A I , Rubtsov A N , Shlyapnikov G V , Straupe S S , Ustinov A V , Zheltikov A M
Published: November 2019

Remarkable advancements in the ability to create, manipulate, and measure quantum systems are paving the way to build next generations of devices based on quantum physics. Quantum technologies in Russia are on the list of strategically important cross-cutting directions in the framework of the National Technology Initiative programs and the Digital Economy National Program. The broad focus includes quantum computing and simulation, quantum communications, quantum metrology and sensing. This paper reviews existing research on quantum science and technologies in Russia and summarizes the main goals for the next few years that form the basis of an upcoming major national initiative.
Delivering an Integrated Adolescent Multi-Agency Specialist Service to Families with Adolescents at Risk of Care: Outcomes and Learning from the First Ten Years
Authors: Talbot Laura , Fuggle Peter , Foyston Zoe , Lawson Kim
Published: November 2019

This article presents a ten-year service evaluation of the Adolescent Multi-Agency Specialist Service (AMASS), an edge of care service based within Islington Children’s Services. A description of the AMASS model and the social care and mental health outcomes for the cohort of families supported by the service across this period (n = 181) are presented. The service had a completion rate of 85 per cent and improvements in both social care and mental health outcomes were found for a significant proportion of those who completed the intervention. Placement stabilisation was achieved for 82 per cent of young people across the service’s three referral categories (home stability, foster placement stability and return home from care). Statistically significant reductions in parental report scores were found on the Strengths and Difficulties Questionnaire and two measures of family functioning in a paired sample (n = 48). Potential learning arising from the AMASS model, in terms of implications for service design for adolescent edge of care interventions, and the limitations of this service evaluation are discussed.
EXAMINING AGEISM IN UNDERGRADUATE STUDENTS THROUGH DRAWING
Authors: Terhune Katherina N , Guest Aaron , Kruger Tina M
Published: November 2019

Substantial demographic shifts in the U.S. will result in the growth of the aging population and the need for qualified professionals entering the field of aging. Yet, these emerging professionals have limited exposure to aging curricula. It is vital that gerontologists recognize the ageism present in how older adults and the aging process are viewed, as this ultimately impacts how they are treated. Data from 1,609 undergraduate surveys from the multi-institution, multi-year Gerontological Literacy Network can assist in our understanding emerging professionals’ perspectives. Results indicate students incorrectly associate aging with loss of function and a reliance on assistive devices (canes 29.3% and glasses 19.6%), physical changes (balding 27.3% and wrinkles 30.3%), and greater likelihood of being male (32.5%). Aging is thought of as time passing (16.1%) and death (14.2%). Findings reveal a need to reframe students’ understanding of aging from that of decline to recognizing the strengths associated with age.
AGE AND USE OF COMPLEMENTARY AND ALTERNATIVE MEDICINE
Authors: Halpin Sean N , Potapragaa Nivedita R , Bergquist Sharon H , Jarrett Thomas
Published: November 2019

Complementary and alternative medicines (CAM) are often obtained over the counter and not disclosed to health care practitioners—leading to possible unforeseen, harmful drug interactions. These concerns are especially true for older adults who have a high likelihood of experiencing multiple comorbidities. Yet few studies examine the patterns of CAM use and disclosure across a wide age range. We used a mixed-methods in a study on patient attitudes toward CAM in a large primary care setting. Participants (n=279) ranged in age from 21-85 (mean=58), were mostly white (75%), and had a bachelor’s degree or higher (83%). Most rated their physical health as good or very good (90%) and had a score of zero on the Charlson Comorbidity Index (76%). Use and disclosure of twelve types of CAM were assessed across three modalities including ingestible (e.g., herbs), psychological/mind-body (e.g., meditation), and physical (e.g., acupuncture). Age was not predictive of disclosure across the larger sample, but within respondents aged 65-85 (n=90), linear regression analyses showed likelihood of disclosure was associated with younger age, positive attitudes toward CAM, and expectation that their physician had positive attitudes about CAM. Semi-structured phone interviews (n=32) revealed older adults were more likely to have long-term CAM use, particularly for pain, and not feel it necessary to disclose to their physician. Meanwhile younger individuals reported trying CAM episodically for preventative health purposes. Understanding patterns of CAM use can help guide age-appropriate conversations and limit possible adverse outcomes from non-disclosure.
AGEISM FIRST AID: AN ONLINE COURSE DESIGNED TO ADVANCE GERONTOLOGY AND COMBAT AGEISM WITHIN THE HELPING PROFESSIONS
Authors: Reynolds Laurinda , Kruger Tina M , Knight Rebekah
Published: November 2019

Ageism First Aid is an online course designed to combat ageism, advance Gerontology, and generate revenue for Gerontology programs and GSA/AGHE activities. The project was funded by a grant from the Retirement Research Foundation and sponsored by the AGHE Academic Program Development Committee. The AFA course content is informed by developmental, social, and cognitive psychology, sociocultural and cognitive linguistics, speech-language science, and geriatrics. The content cultivates ageism awareness by replacing the common misconceptions about aging that underlie ageism with facts. The content also cultivates cultural consciousness and uses concise common language accessible to learners of diverse backgrounds. During this symposium, participants will be introduced to the course content and explore the benefits of this multidisciplinary approach to curriculum development. The results summary of the AFA course pilot will be presented as evidence of the course efficacy. Participants will leave able to utilize AFA within their institutions and local Aging Networks.
WORKING WITH OR WITHOUT AGING SPECIALISTS: WHERE ARE THE GERONTOLOGISTS?
Authors: Ewen Heidi H
Published: November 2019

One question asked by generations of gerontology doctoral students is what types of employment can be secured after completing the PhD in Gerontology. The Gerontology Education Longitudinal Study (GELS) has surveyed graduate students and alumni of the various doctoral programs in order to understand the career trajectories of graduates. Of 102 alumni surveyed in 2014 (42% response rate), the majority (60%) were not working with other people who had degrees in gerontology, yet 51% report working with at least some people who have experience with aging and older adults. On the job, graduates say that their duties require knowledge and mastery of public policy issues, health and medical aspects related to aging, and psychological theories. As aging experts, it is inherent in their work to combat ageism and reduce age-related stereotypes. As such, gerontologists are using substantive content expertise within their careers and serving as experts in aging.
ORGANIZATIONAL AND COMMUNITY FACTORS ASSOCIATED WITH NURSING HOME ORGANIZATIONAL CULTURE
Authors: Ghiasi Akbar , Davlyatov Ganisher K , Lord Justin C , Weech-Maldonado Robert
Published: November 2019

This study examines how organizational and community factors are associated with organizational culture among high Medicaid nursing homes (70% or higher Medicaid census). According to the Competing Values, Framework, there are four types of organizational culture: clan culture (friendly working environment); adhocracy culture (dynamic/creative working environment); market culture (results-based organization); and hierarchy culture (formalized/structured work environment). Survey data from 324 nursing home administrators (30% response rate) from 2017- 2018 were merged with secondary data from LTCFocus, Area Health Resource File, and Medicare Cost Reports. The dependent variable consisted of organizational culture type. The independent variables comprised organizational factors (facility has nurse practitioner/physician assistant (NP/PA), RN/LPN/CNA hours per resident day, RN skill mix, ownership, chain affiliation, size, occupancy rate, and Medicare and Medicaid payer mix) and community factors (Medicare Advantage penetration, per capita income, educational level, unemployment rate, poverty level and competition). Multinomial regression results showed that, compared to facilities with hierarchical cultures, those with a market culture have greater odds of having an NP/PA and higher RN skill mix and LPN intensity, but lower odds for RN intensity, Medicaid payer mix, occupancy rate, and Black residents. Also compared to facilities with hierarchical cultures, those with a clan culture have lower odds for having an NP/PA, beds and occupancy rate, but higher odds of being located in communities with lower unemployment and higher Medicare managed care. In conclusion, different organizational cultures are associated with different staffing patterns, as well as organizational and community factors.
ADVERSE CHILDHOOD EXPERIENCES PREDICTING INMATE STATUS AMONG OLDER COMMUNITY DWELLERS
Authors: Yang Mai S , Hedeker Donald
Published: November 2019

The goal of this study was to see if whether having exposure to early child adversity predicted inmate status among older adults. Very little research has focused on the relationship between inmate status and older adults, and factors that could predict someone being imprisoned. This study used data from the Health and Retirement Study (2006 – 2014) (N = 1,070) to examine this association. We used logit models to test if specific adverse childhood experience and race groups predicted inmate status among community dwellers age 55 and older (M = 72.2, SD = 8.5). More than half of the respondents were female (59%). About 1.9% respondent identified as non-Hispanic other, 7.2 % as Hispanics, 14.2% as non-Hispanic black, and 76.7% as non-Hispanic Whites. In terms of former inmate status 14% of the respondent indicated having been an inmate in jail or other correctional facility. Preliminary findings suggest predictors of inmate status were those who had trouble with the law in early adolescent years and those who self-reported as black. Findings from this study could provide insight into how early childhood experiences could predict inmate status in adulthood among older adults.