bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTS OF ISOLATED LA MAZE PROCEDURE ON CARDIAC DIMENSIONS, RHYTHM AND VENTRICULAR FUNCTION AMONG SURGICAL PATIENTS OF MITRAL VALVULAR HEART DISEASE WITH PERSISTENT ATRIAL FIBRILLATION
Authors: Saha Debarshi , Halder Ashis , Halder Suranjan , Krishna Sarkar Binay
Published: November 2023

Background:Atrial Fibrillation (AF) being one of the commonest arrhythmia is strongly associated withdebilitated quality of life with increased
morbidity and mortality.The maze procedure is a useful surgical modality for sinus rhythm restoration in patients with AF undergoing cardiac valve
surgery. Isolated Ablation of the left atrium (LA)found to be superior in terms of higher efcacy in reversal to normal sinus rhythm. The present
study was conducted planned to assess the effects of isolated LAmaze procedure by diathermy on the cardiac dimensions, ventricular function and
return to sinus rhythm post operatively among patients of mitral valvular heart disease with persistent atrial brillation. Materials & methods:An
institution based descriptive study with prospective design was conducted over one and half year duration at the Department of CTVS , NRS
Medical College & Hospital, Kolkata. In this study, 70 diagnosed cases of Mitral valve disease (MVD) with persistent AF undergoing mitral valve
st rd
surgery with concomitant isolated LA Maze procedureby diathermy admitted at the institute and followed up at 1 and 3 months postoperatively.Data were analysed using the SPSS version 20 software and checked for normal distribution; parametric or non-parametric test was
performed accordingly. The difference between proportions was analysed using Chi square test; p value of less than 0.05 was considered
statistically signicant. Results: The mean age of the study population was 45 ± 6.45 years. The mean Left ventricular internal diameter (LVID)
decreased signicantly after the procedure (p value <0.001). Age (p value-0.006), NYHA Class (p value-0.006) and LVEF (p value<0.001) were
rd signicantly associated with the outcome of LAmaze procedure at 3 months of follow up. Conclusion:Improved LVfunction and maintenance of
sinus rhythm were encouraging results after LAmaze procedure using diathermy along with Mitral valve surgery.
AWARENESS SURVEY ON NEWBORN, THALASSEMIAAND PREGNANCY SCREENING TESTING
Authors: Uppal Komal , Nijhawan Richa , Polipalli Sunil Kumar , Kumar Somesh , Kapoor Seema
Published: November 2023

In developing countries, awareness about genetic conditions like Down syndrome, congenital defects, thalassemia, and inborn errors of
metabolism is limited. We conducted a survey using a 19-question questionnaire to assess awareness of newborn, thalassemia, and pregnancy
screening and whether these tests should be recommended or not among junior doctors, senior clinicians, MBBS students, and the general
population. Results showed that only 60% of junior doctors knew about thalassemia screening. 50-70% of doctors and 60% of students supported
invasive pregnancy testing. Approximately 35% of students were unaware of thalassemia carrier screening but 80% of them were open to routine
testing. 90% of students recognized the importance of genetic screening awareness in current health scanario. About 40-60% of the general public
lacked awareness about screening tests and the distinction between screening and diagnostic tests. Nearly 50% - 60% of people understood the
importance of thalassemia screening. Although many clinicians and students acknowledged the benets of screening tests, yet, increased
awareness and attitude change, along with improved genetic education in medical curricula is needed.
A STUDY TO ASSESS PLATELET-TO-LYMPHOCYTE RATIO AND NEUTROPHILTO-LYMPHOCYTE RATIO FOR PREDICTING SEVERITY OF MUCOSAL DISEASE IN ULCERATIVE COLITIS.
Authors: Soni Rashmi , Dhayal Sonu , Gulati Sandhya , Sharma Nidhi
Published: November 2023

Background: Ulcerative colitis (UC), a chronic inammatory bowel disease of uncertain etiology, is characterized by recurring episodes of
inammation limited to mucosal layer of colon and rectum. As systemic inammatory response is associated with alteration in circulating
leukocytes, specically the presence of neutrophilia with relative lymphocytopenia; and thrombocytosis; these inammatory changes were studied
to predict the level of inammation in UC by using derived markers. Methods: This hospital-based analytical observational study was conducted
using 3 groups (active UC disease; UC patients in remission; and healthy controls) with sample size of 30 each. Neutrophil-to-lymphocyte ratio
(NLR) and platelet-to-lymphocyte ratio (PLR) were derived from neutrophil count, lymphocyte count and platelet count. Results: Mean values of
NLR, ESR and CRP were highest in active group and lowest in controls while PLR was highest in remission group and lowest in controls. This
difference was statistically signicant (p<0.05). Between mild disease subgroup and moderate-to-severe disease subgroup, no statistically
signicant difference was found for all the studied CBC parameters, NLR, PLR, ESR and CRP. There was no statistically signicant correlation of
ulcerative colitis endoscopic index of severity (UCEIS) with different variables in active and remission groups. Conclusion: NLR and PLR were
signicantly elevated in UC patients.
THE PROGNOSTIC INDICATORS OF HIGH GRADE GLIOMA-GBM : ANALYSIS OF 50 PATIENTS
Authors: Gupta Poonam
Published: November 2023

Background- The GBM is malignant glioma.GBM is diffusely inltrative, involving large portions of the brain. MRI characteristically shows
vasogenic edema and ring enhancement around central necrotic regions. The prognosis for patients with GBM is poor with median survival time of
approximately 14 months in highly selected patients receiving contemporary treatment. Pretreatment patient and tumor characteristics such as age
at diagnosis, tumor histology, and Karnofsky performance status (KPS) are the best predictors of outcome. Extent of resection, duration of
neurologic symptoms, and radiographic response to treatment have also been suggested as predictors of survival. Material & Method- This study
was done in 50 patients with GBM who were diagnosed from 2019 to 2022.They all underwent surgery followed by radiotherapy 60gy in 30# with
tab temozolamide 75 mg/m2 and after completion of radiation tab temozolamide 150mg /m2 added in adjuvant setting further. Results- After
analysis of 50 patients 9 patients were female and remaining were male. During the study period 6 out of 50 patients died during course of radiation.
7patients died with in 2 months after completion of radiation. Remaining patients had progression free survival minimum 3 month and maximum
24 months. Conclusion-The patients with gross total resection, good KPS score and younger age group had better survival and quality of life
STUDY OF VARIOUS RISK FACTORS AND SYSTEMS INVOLVED IN SEPTICEMIA
Authors: Panchal Manisha , Bhapal Meghavi , Mehta Ishita
Published: November 2023

Sepsis is body's response to an infection. Sepsis cause danger to life. Sepsis occurs due to dysregulated immune response toward infection which
leads to septic shock and through this multiple organ failure and leads to death. In most case of sepsis, medical professional recognises sepsis
somehow delay which cause increase morbidity and mortality. In this study, we include various risk factors and various systems of body involved in
septicemia which could be useful to early identication of septicemia lead to early treatment and by this decrease morbidity and mortality.
GIANT RETROPERITONEAL TERATOMA IN AN ADULT FEMALE WITH ABDOMINAL DISTENSION: A CASE REPORT
Authors: Khatun Monalisa
Published: November 2023

A teratoma is a true neoplasm that comprises of tissues developing from 2 or more germ cell layers. Here we present a case report of 36 years old
female patient presenting with progressive abdominal swelling and severe pain in right-half of abdomen predominantly in upper part. Clinical
examination revealed a mass in epigastrium extending to umbilical region. Radiological imaging revealed a large, well encapsulated, heterogenous
mass in right retroperitoneal region showing fat components with few incomplete septations, calcication and solid component without
hemorrhage. She underwent exploratory laparotomy which conrmed the radiological ndings. Histopathological ndings were suggestive of
mature teratoma.
PROFILE OF TUBERCULOSIS IN CHILDREN (0-18 YEARS): A HOSPITAL BASED STUDY FROM MEGHALAYA, INDIA
Authors: Rajan Chinchu , Deb Santanu , Ranjan Gogoi Palash , Paul Prasenjit , Yesmin Sabrina , Sangla Lima , Paharia Pramod
Published: November 2023

Objective: To record the various demographic details and presentation of all types of tuberculosis presenting in children (0-18 years). Design:
Prospective observational Setting: Department of Pediatrics & Neonatology, Nazareth Hospital, Shillong, Meghalaya. Participants:All children
below 18 completed years of age diagnosed with any form of tuberculosis. Main outcome measures: Various demographic details, clinical
presentations, and relevant investigations of all types of tuberculosis. Results: 31 children and adolescents with tuberculosis were included in the
study. Among 31 patients, most (87%) belonged to the 12 to 18 years of age group. Females (51.61%) were more common. Most of the patients
belonged to the Class V socioeconomic class and lived in overcrowded rooms (54.8%). Most of them were malnourished (51.6%). Second hand
smoking was present in 70 % of patients. History of contact with pulmonary TB cases was seen in only 38.7% of patients. BCG scar was present in
38.7% of patients. Fever (54.8%) was the most common symptom followed by cough (51.6%) and weight loss (41.9%). The most common type of
TB was extrapulmonary TB (45.16%) followed by pulmonary TB (35.48%) and disseminated TB (19.35%). Microbiologically conrmed cases
(64.52%) were more common than clinically diagnosed cases (35.48%). Smear positivity was seen in only 19.3% of patients. Chest X-ray
suggestive of TB was present in 45.1% of patients. CBNAAT positivity was seen in 45.1% of patients. Conclusions: The commonest form of
tuberculosis was extrapulmonary TB followed by Pulmonary and disseminated tuberculosis in our study
A RARE CASE REPORT ON UNILATERAL LIMBAL DERMOID AS AN ISOLATED FINDING
Authors: Kochar Rashi , Ahuja Nisha , Agarwalla Vijaya
Published: November 2023

A 16-year-old girl came to our hospital with complaint of a disguring mass in her right eye that she had known about since birth and that had
gradually grown in size.. Anterior segment assessment revealed a rm pale oval mass between 6 and 9 o'clock in the right eye's inferotemporal
limbus that was not obscuring the visual axis. On detailed systemic evaluation, there was no facial asymmetry, no vertebral anomaly or any other
systemic abnormalities. Our patient was advised for surgical excision followed by restorative multilayered amniotic membrane transplanting.
Limbal dermoids are congenital benign tumours that cause astigmatism, encroachment on the visual axis, and fatty component inltration into the
cornea, resulting in vision impairments. They are made up of enlargements of epidermal appendages, connective tissues, skin, fat, sweat glands,
lacrimal glands, and neurological structures that are partially over the cornea and partially over the sclera.
“A STUDY ON ROLE OF RETICULOCYTE HEMOGLOBIN-CONCENTRATION IN PREVENTION OF BEHAVIOURAL DISORDERS DUE TO IRON DEFICIENCY”
Authors: Varma B S K Chandra Deve
Published: November 2023

Introduction: Iron is required for electron transport, adenosine triphosphate (ATP) production, DNA synthesis, mitochondrial function,
neurotransmitter synthesis, and myelination and is critical for brain growth and function. The effects of iron deciency are anemia and most
importantly neurodevelopmental impairments which are long lasting and sometimes irreversible. The main goal of this study was to Aims:
estimate the prevalence of Iron deciency in children with behavioural alterations and to know the correlation between these behavioural
alterations and iron deciency. This is a prospective cohort study done on 250 healt Materials And Methods: hy children with behavioural
alterations (irritability, mood swings, poor school performance, loss of appetite and pica) at a tertiary care hospital, south India. Blood samples of
these children were collected and sent for red blood cell indices (Hemoglobin, mean corpuscular haemoglobin, mean corpuscular volume,
reticulocyte haemoglobin concentration). We performed a statistical comparison between behavioural alterations and red blood cell indices by
using a paired t-test and chi-square test for multiple groups. A probability of P<0.05 (two-sided) was used to consider the difference as signicant.
Results: In the present study, the poor school performance, poor appetite, pica are statistically signicant with respect to only decreased
hemoglobin but not to decreased reticulocyte hemoglobin (CHr), we can correlate these symptoms mainly to manifested iron deciency anemia
rather than latent iron deciency. Mood swings and irritability are statistically signicant with respect to both decreased hemoglobin and decreased
chr so we can correlate these symptoms to the stage of latent iron deciency without manifested anemia. Iron deciency per se causes Conclusions:
behavioural disorders with or without anemia. Reticulocyte hemoglobin can be used as a marker for early iron deciency which is comparatively
cheaper than other early iron deciency markers. All infants and children should be supplemented with iron during latent phase of iron deciency to
prevent behavioural disorders.
PHYSICIAN TEAM IN PARTAKING DOMICILIARY ATTENDANCE FOR THEIR PATIENTS FROM A CANCER CENTRE - ANALYTICAL STUDY REVIEW.
Authors: Adil. A Mohamed , Jayakumar Indira , Ramcharan Kattoju Ajai , Sudhakar K. , S Afshan.
Published: November 2023

Background: There is a global need for Domestic Visit (DV) by physician lead team for Domestic treatment. DV has an excellent health care
outcome. This aims at DV assistance for oncologically diagnosed patients, with objectives of service provision to patients requiring home visit by
the medical team and by utilizing the DV and telemedicine linked to the internal data in the tertiary cancer center. Purpose: To bring the highest
possible escalation in management by DV that contributes the health care level a step higher than existed. Materials And Methods: All DV are
attended with ambulance equipped with crash cart and a quick preparation of the details of previous visit. Seventy three visits attended during
March 2019 to August 2020.Study Results: The number of DV had an increase in patients diagnosed with malignancy of Breast 27.4%, brain
Astrocytoma 13.7%, Rectum 13.7%, Colon 9.5%, Lymphoma 5.5%, Hepato cellular carcinoma 5.5% together comprising of more than 75% of the
total DV. Hodgkin's lymphoma, Non Hodgkin's lymphoma, Mantle cell lymphoma, malignancy of Hypopharynx, malignancy of Prostate,
Squamous cell carcinoma, Periampullary carcinoma comprised 1.4%. The lung neoplasms were 4.1%. Malignant melanoma, Renal cell
carcinoma, brain Oligodendroglioma and other Post Onco Surgery 2.7%. Conclusion: Age, Gender, Types ,Stages Presentation and DV treatment
has signicance and there was no mortality in our domestic visit .
MINISCREWS: DESIGN CONSIDERATIONS IN ORTHODONTICS
Authors: P Nasla. , Santhakumaran Nair Praveen , Parayaruthottam Prathapan , Vadakkeypeediakkal Latheef , Jisha Baby , Shibin P Muhammed
Published: November 2023

The eld of orthodontics has seen a tremendous increase in the use of Temporary anchorage devices (TADs) , which help to cater the anchorage
demands of different treatment situations, at the same time reducing unwanted effects of orthodontic forces. Miniscrews are the most commonly
used TADs, which are effective in most clinical situations. This review covers in detail about the parts of a miniscrew, the materials used for
fabrication and the clinical signicance. Fine details like thread pitch , thread shape and thread depth of different designs of miniscrews are also
explained in depth along with a note on safe zones for miniscrew placement. Relevant articles from Pubmed, Web of science and Google scholar
were selected for review.
SUBNORMAL TOTALANTIOXIDANT ACTIVITY IN BLOOD SERUM OF NEWLY DIAGNOSED NON-COMMUNICABLE DISEASE SUBJECTS: A PREFATORY STUDY
Authors: Kumar Sushil
Published: November 2023

Purpose: The incidences of Non-Communicable Diseases (NCDs) are increasing globally and are major contributors of morbidity and mortality
worldwide. Their incidence is considered to be linked to imbalance in intracellular generation of Reactive Oxygen Species (ROS) and adequate
level of antioxidants that leads consecutively to development of intracellular Oxidative Stress (OS), pro-inammatory changes followed by
systemic inammation. In view of this concept the level of antioxidants namely the Total Antioxidant Activity (TAA) was determined in blood
serum of newly diagnosed NCD subjects. Methods: Serum samples were obtained from OPD of a tertiary care hospital in district Barabanki Uttar
Pradesh. Test subjects were categorized to explore gender or age related changes. Central tendencies of sTAA data viz. mean, median, and mode
values were calculated. Results: Mean sTAAvalue in NCD subjects was found to be signicantly low compared to mean value of sTAAin healthy
subjects. Mode value was found to be low in male compared to female subjects; moreover, age wise decrease in mean, median and mode values of
sTAAwas also noticed. Conclusion: Conclusively, sTAAis found to be decreased in newly diagnosed NCD subjects. (word counts 182)
DIFFUSION TENSOR IMAGING (DTI) EVALUATION IN COMMON PATHOLOGIES OF BRAIN ON 3 TESLA MAGNETIC RESONANCE IMAGING (MRI) SCAN.
Authors: V. Mehta Deepakkumar , Sharma Dolly Anil
Published: November 2023

Background: Medical and scientic settings are increasingly using Diffusion Tensor Imaging (DTI) for clinical purposes. Advance evaluation of
common disorders of the brain that affect the integrity of white matter can be done using Diffusion Tensor Imaging with Fractional Anisotropy
(FA), besides routinely used Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefcient (ADC); so besides routine image
interpretation, DTI evaluation gives assessment of integrity of white matter ber tracts; which are quite necessary for the prognosis in many brain
pathologies. To compare the Fractional Anisotropy (FA) values in white matte Purpose: r on both side of brain in the control group of normal
persons and patient group of patients having brain disease/abnormality/lesion by Diffusion Tensor Imaging (DTI) on 3T MRI scan. Materials and
Methods: Fifty-two patients having normal routine MRI study of brain and another fty-two patients having brain disease/lesion/abnormality on
routine MRI scan of Brain were included in this prospective case control cross-sectional research study. The approval of this research study from
Institutional Ethical Committee (IEC) was obtained before the research study was started. The FA values were measured in the pre-dened ten
specic regions of white matter on right side and left side of brain using ROI-based measurements. The differences in FA values in white matter in
same area on both side of brain were analyzed using mean, standard deviation and paired T test. The FA values were observed signicantly Results:
differ in various regions of the brain in normal group specially in the areas of composed, complex and crossing bers. The FA values were observed
higher in the splenium followed by the genu, body and posterior limb of the internal capsule in both groups. However, on comparison of the FA
values at the pre-dened ten specic regions on right side and left side of brain found in the control group and found in the patient group; statistical
signicance was observed in the FA values measures on right side of centrum semiovale and in the midbrain on both sides. The FA Conclusion:
values were found to be greater and to vary regionally in different areas of white matter. The control group showed very little differences between
right and left side of brain at the same white matter area or at same level of white matter tract; however, these results must be kept in consideration
and should be acknowledged when interpreting them in clinical context.
COMPARISON OF CYTOLOGY OF BODY FLUIDS USING ROUTINE SMEAR EXAMINATION AND CELL BLOCK TECHNIQUE
Authors: Pancholi Neeraj , Bhushan Reema , Niranjan Amit Kumar , Dhakad Sapna
Published: November 2023

Introduction: Body uids mainly comprises of peritoneal uid, pleural uid, synovial uid, and cerebrospinal uid (CSF). In the several
inammatory & neoplastic conditions, cells are exfoliated into these uids and their study help in reaching denitive diagnosis. The cell block
technique is one of the senescent and complementary methods in addition to the smear for examination of body cavity effusions Aim: To study
cytology of various body uid by using routine staining and cell block technique by specimens received in Department of Pathology G. R. Medical
College & J. A. Group of Hospitals Gwalior from December 2021 to May 2023. Material and Method: A hundred cases of serous effusion were
collected from different clinical departments. At rst uid were examined for their physical characteristics. Secondly it is divided in to two halves.
One half was processed by routine technique and stained using Giemsa Stain & Papanicolaou stain. Remaining uid was subjected to modied cell
block technique using ethyl alcohol formalin combination and processed like a histopathology sample. These uids were analysed for physical
properties like the uid volume, odour, and colour. Each individual slide was objectively analysed for cellularity, cell crowding, nuclear
preservation, cytoplasmic preservation, background, and the ability to make denite diagnosis on them. Routine smears and cell block were both
objectively given scores according to Mair et al criteria. Results: Out of total 100 cases, 49 were pleural uid, 48 were ascitic uid and 3 were
synovial uid. Maximum number of patient (19%) were in the age group of 41-50 years. On smear examination, 10/100 cases were reported
positive for malignant cells. Cell block examination showed 12/100 positive cases for malignant cells. According to the scoring system, smears
could obtain a maximum score of only '7' (n= 8) while cell block could secure '8' (n= 10). Two (2%) smears were unsuitable for diagnosis by smear
examination and 24 (24%) smears were diagnostically superior. Cell block slides showed that 12 (12%) cases were unsuitable for diagnosis, but
majority 46 (46%) cell blocks were diagnostically superior. Conclusion: Cell block increase the sensitivity of cytodiagnosis of serous uids with
main advantage of getting many sections for special stains and other ancillary techniques, especially immunohistochemical studies.
CLINICAL STUDY ON BUERGER'S DISEASE AT A TERTIARY CARE TEACHING HOSPITAL, SILCHAR
Authors: Ahmad Faizan , Mazumder Asik Iqbal , Thomas Jessmon , Venugopal Vivek , Bahar H.M. Iqbal
Published: November 2023

Background: Buerger's disease or thromboangitis obliterans (TAO) is a distinct clinical and pathological entity. It is dened as a nonatherosclerotic, segmental, inammatory, occlusive vascular disease of unknown etiology occurring predominantly in young male smokers and
affecting small and medium-sized vessels predominantly. No form of treatment has been successful in offering the victims of this disease a cure or
even a long-term remission. Management of Buerger's is meant primarily to mitigate the sufferings of the victims and afford them the maximum
comfort. 30 patients who are fullling the diagnostic criteria of Shionoya have bee Method: n studied prospectively in detail during the period from
May 2021 to April 2023 at Silchar Medical College and Hospital, Silchar, Assam, India. Majority of the patients (60.00%) were in the age Results:
group of 31-40 years. All the patients were males. Majority of the patients (80.00%) were from low socio-economic status. All 30 patients had the
involvement of lower extremities. There were no non-smokers in the series. Most of the patients in the series were heavy smokers, who smoked
more than 20-25 beedies per day. Claudication was the commonest presentation. Other presentations were ulceration, rest pain, pigmentation,
odema, and gangrene. All the patients had infrapopliteal pulsation involvement. Majority of the patients were managed conservatively with
smoking cessation. Lumber sympathectomy was performed in 6 patients who were having complain of rest pain. Disarticulation was performed in
2 patients with gangrene who had a denite line of demarcation. Unknown in its Conclusions: etiology, Buerger's Disease is a medical illness that
is intrinsically tied to tobacco abuse. Since surgical revascularization is typically not an option, alternative therapies are crucial, albeit there aren't
many randomized clinical trials looking at how well they work. Lumbar sympathectomy is one viable option for rest pain. But right now, the
foundation of management is complete cessation of all cigarette usage.
TO STUDY AND COMPARE THE EFFICACY OF FEMORAL NERVE BLOCK VS. ADDUCTOR CANAL BLOCK WHEN USED AS A PART OF MULTIMODAL ANALGESIA REGIMEN IN PATIENTS UNDERGOING TOTAL KNEE ARTHROPLASTY PERFORMED UNDER SUBARACHNOID BLOCK.
Authors: Meneni Dilip , Bhukya Raju , Goud R Srujan
Published: November 2023

Total Knee Arthroplasty (TKA) is a common orthopaedic procedure, consisting of replacing diseased or damaged knee joint surfaces to relieve the
pain and disability of osteoarthritis. We aim to study and compare the efcacy of femoral nerve block and adductor canal block when used as a part
of a multimodal analgesia regimen in patients undergoing Total Knee Arthroplasty under subarachnoid block. The ASA strongly recommends that
a regional blockade with local anaesthetics be considered part of the multimodal approach for pain management. Regional block such as femoral
nerve block, with local anaesthetics, remains a well-accepted component of comprehensive multimodal anaesthesia for postoperative pain
management. To assess the effect of femoral nerve block and adductor canal bl Objectives: ock on the Pain intensity by NRS scale at specic time
intervals, till 24 hours post block, the duration of sensory blockade, the duration of motor blockade and to measure the total amount of opioids
consumed, till 24 hours post block. Surabhi Institute of Medical Sciences, Siddipe Study Area: Study population: t, Telangana. The study
population was limited to the patients undergoing elective TKA under SAB. T Sample size & sample technique: he sample size was limited to 150
patients systematically divided into two equal groups of 75 patients in each group. We found that the mean NRS pain scores at 6 hours, 12 Results:
hours and 24 hours in both groups were similar with the difference being statistically insignicant. In group A, The mean NRS pain score at 6 hours
was 2.8400 ± 1.4708 and in group B it was 2.6933 ± 1.5594 with a p-value of 0.5544. The mean NRS pain score at 12 hours in group A was 4.9467 ±
1.3939; in group B it was 4.9067 ± 1.2858 with a p-value of 0.8553. The mean NRS pain score at 24 hours in group A was 3.0533 ± 1.4036 and in
group B it was 2.9733 ± 1.3252 with a p-value of 0.7202. We found that the difference in duration of sensory block was also not statistically
signicant in both the groups with a mean duration of sensory block in hours being 9.2400 ±1.8733 in group A and 8.8133 ±1.9844 in group B with a
p-value of 0.1778 and the total amount of opioid consumption was also similar in both the groups with the mean opioid (Inj: fentanyl) consumption
in micrograms being 132.6000± 31.9666 in group A and 134.3333 ± 30.4841 in group B with p-value of 0.7345
A NOVEL IN-HOUSE MATRIX-SYNCED METHOD OF OVERCOMING LIPEMIAINDUCED INTERFERENCE AMONG SELECTED BIOCHEMICAL PARAMETERS, IN A SUPER SPECIALITY HOSPITAL OF KOLKATA
Authors: Sen Susruta , Pathak Indrani , Sarkar Niladri , Mukherjee Kalyan , Sarkar Ayonava , Debroy Saurajit , Choudhuri Sharmistha
Published: November 2023

Introduction: Interference due to lipemia, accounts for a signicant source of analytical errors in clinical laboratory settings, and necessitate
removal prior to measuring biochemical parameters. We aimed to investigate whether such interference in serum/plasma samples can be removed
using a method that is easier and more practicable than ultracentrifugation, the current reference method. A total of 134 serum samples Methods:
were screened for two specic parameters, particularly vulnerable to lipemia-related interference; these being ALT (Alanine transaminase) and
AST (Aspartate transaminase), from 01/04/2023 to 30/04/2023. In parallel, for overcoming lipemia, separate sera having albumin > 3.5 g/dL were
pooled, to constitute our matrix-synced diluent. Lipemia was induced into serum samples where interference was to be studied, using intralipid
solution (5 µL/250 µL serum). These samples were then diluted with our matrix-synced diluent, in 1:3 and 1:4 ratio and re-estimated for ALT and
AST activities. The values thus obtained were then adjusted for the contribution by the pooled sera and the nal values recorded. The data was
analyzed by GraphPad Prism (v.8.0), considering a P value of ≤ 0.05 to be statistically signicant. Out of the 134 samples, 34 and 53 in 1:3 Results:
& 1:4 dilutions respectively showed positive and signicant correlation (Spearman r=0.9556, P <0.0001; Pearson r=0.9990, P <0.0001), between
ALT activity in non-lipemic serum and in lipemia-induced serum diluted with our matrix-synced diluent. A similar correlation (Spearman
r=0.9432, P <0.0001; Spearman r=0.9764, P <0.0001), was found between AST activity in non-lipemic serum and in lipemia-induced serum in in
57 and 77 samples with 1:3 & 1:4 dilutions respectively. Our matrix-synced dilue Conclusions: nt thus proved to be a simple and effective strategy
in overcoming interference dure to lipemia, w.r.t. ALT and AST activities, which are highly prone to give erroneous values in grossly lipemic
samples.
EVALUATION OF DIGITAL EYE STRAIN IN COMPUTER USERS
Authors: Namratha Gaddam , Lydia K. , Suresh V. Naga , Pushpalatha M.
Published: November 2023

Introduction:The number of computer users has rapidly increased throughout the world and is expected to reach 1 billion as a result of an
increasing in number of new computer users in developing countries such as India, China and Russia.This study was done to determine the
prevalence of digital eye strain (DES) /asthenopia and ocular risk factors involved in the causation of asthenopia among computer users.
Objectives: The objective of the study is to evaluate incidence of digital eye strain and ocular risk factors involved in causation of DES among
computer users. The present study is conducted among engineering college students ,soft Materials And Methods: ware computer users who has
attended our OPD ,Viswabharathi medical college, penchikalapadu,Kurnool.The study included 200 no.of individuals who were screened
ophthalmic examination include refraction ,cover test ,positive fusional vergence ,near point of convergence ,amplitude of accomodation, schirmer
II test and structured questionnaire. The observations and results were tabulated accordingly, and data were analyzed using the SPSS version. The
unpaired t-test is used as the test of signicance and P value is statistically signicant when it is < 0.05 Overall, 200 students were include Results: d
in the study. Incidence of asthenopia was seen in 112 students,45 male ,67 female. In this study, The incidence of digital eye strain in Conclusion :
computer users is signicant and it is more in females when compared to the males. In myopes it is more common, heterophorias are more common
than heterotropias .The most common symptoms are head ache, tired eyes and watering of eyes.There is slight increase in the incidence of
asthenopia as the no of years of usage is increased and increase in hours of usage. Asthenopia is more when the distance is less than 45 cm from the
screen and when the top of the monitor at the same level of eyes. The asthenopia is more in students not using antiglare screen when compared to
using antiglare screen.
CONGENITAL ZIKA SYNDROME
Authors: Alatekar Supriya
Published: November 2023

Zika virus is a mosquitoborne avivirus that is the focus of an ongoing pandemic and public health emergency. Previously limited to sporadic cases in Africa and Asia, the emergence of Zika virus in Brazil in 2015 heralded rapid spread throughout the Americas. Although most Zika virus infections are characterized by subclinical or mild inuenza-like illness, severe manifestations have been described, including Guillain-Barre syndrome in adults and microcephaly in babies born to infected mothers DEDF.1 About 1 in 10 pregnant women (10 percent) with Zika infection in the United States and the District of Columbia has a baby with birth defects. Abirth defect is a health condition that is present at birth. Birth defects change the shape or function of one or more parts of the body. They can cause problems in overall health, in how the body develops or in how the
2 body works.
A CLINICAL STUDY ON SIGMOID VOLVULUS IN ADULTS
Authors: Chandran Sameer , Jareena Jareena
Published: November 2023

Background: Sigmoid volvulus is an abnormal twisting of the bowel on its mesenteric axis >1800.First described by Von Rokitansky in 1836.
Aims and Objectives:The aim of this study is to highlight the clinical features, management of sigmoid volvulus and its outcome in terms of
morbidity and mortality. This study was a retrospective study conducted on 30 patie Methods: nts who have been diagnosed with sigmoid volvulus
in department of general surgery and Surgical Gastroenterology,Narayana Medical college and Hospital,from MARCH 2020 to march 2023.Data
such as age distribution,sex distribution,duration of symptoms, management,post op complications was collected and evaluated. Mean Results:
age of presentation was 52 years(35-80).peak age of incidence was 51-60yrs.Of 30 patients 21 are male and 9 are female.Clinical features are
mostly abdominal distension,abdominalpain,constipation,vomiting,fever,visible peristalsis.duration of symptoms ranges from 2-20 days.mainly
presented as acute symptoms with uncomplicated and viable bowel.18 patients underwent Hartmanns procedure,12 patients underwent resection
and primary anastomosis.Post op complications includes surgical site infection,chest infections,colostomy complications,paralytic ileus,wound
dehiscence,intraabdominal abscess collection. Sigmoid volvulus is a common c Conclusion: ause of large bowel obstruction and males are
commonly affected than females mostly of elderly aged.mostly presented with acute symptoms and management depends on viability of
bowel.Early diagnosis and timely intervention reduces the morbidity.
RADIOTHERAPY IN ANEURYSMAL BONE CYST OF THE OCCIPITAL BONE : A CASE REPORT
Authors: Choudhury Diplu , Kumar Das Kaustav , Borah Luri , Manasa P , Kashyap Koumudi
Published: November 2023

Introduction: Aneurysmal bone cysts (ABCs) is a rare benign tumour of bone with an annual incidence of 0.14 per 100000 population mostly
effecting the appendicular skeleton: femur tibia, bula, humerus followed by skull bones and posterior elements of the spine. The pathogenesis of
ABC still remains a controversial issue Here we are going to describe a c Methods And Materials ase of Aneurysmal Bone Cyst involving the
occipital bone in a 8 year old boy. The boy had initially presented with headache and vomiting for which he was evaluated at Neurosurgery Dept
after which he had undergone subtotal resection. The HPE showed it to be aneurysmal bone cyst. After discussion in the tumour board he was taken
up for adjuvant radiation.He received a total dose of 30.6 Gy in 17 fractions through IMRT technique using daily image guidance. Discussion The
optimal prescription of radiation dose is essential for avoiding the development of adverse reactions to radiotherapy, the recommended dose is
between 26 and 30 Gy using standard fraction size for ABCs. Dose constraints are to be kept in mind for critical OARs while planning an IMRT plan
for such location of the disease. Conclusion Aneurysmal Bone Cyst is an aggressive benign lesion with high rates of recurrence. Mainstay of
treatment is surgery with radiation reserved for adjuvant and unresectable tumours. However the exact treatment of choice depends on the treating
physician
A STUDY ON PLATELET COUNT AND HYPERTENSIVE DISORDERS OF PREGNANCY
Authors: Preet Adarsh , R Anand Ashok
Published: November 2023

Background: Hypertensive disorders of pregnancy are one of the most common medical disorders seen during pregnancy. Out of all
haematological changes that occur in preeclampsia, thrombocytopenia is the most familiar. The frequency and intensity of thrombocytopenia vary
and are dependent on the severity and duration of the preeclampsia syndrome . The objective of this study was to compare platelet count at 12-16
weeks of gestation and time of termination of pregnancy in women with hypertensive disorders of pregnancy and normotensive women.
Methods: A study was conducted in the Department of Obstetrics and Gynaecology at JJ Group of hospitals, Mumbai, India for a duration of 18
months from January 2020 to June 202. This study has a sample size of 500 antenatal patients. Necessary information such as their detailed clinical,
and obstetric history, clinical examination, investigations was noted. In our Results: study, the incidence of hypertensive disorders of pregnancy
was 10.2% .There is no association of low platelet count at 12-16 weeks of gestation and development of hypertensive disorders in our study.
There is association of low platelet count at time of delivery and hypertension in our study. The change in platelet count is signicantly more in
cases of subjects who developed hypertensive disorders of pregnancy as compared to those who did not develop hypertensive disorders of
pregnancy. Hypertensive disorders of pregnancy are one of the medical conditions affe Conclusion: cting pregnancy. Low platelet count at 12-
16 weeks is not predictor of Hypertensive disorders of pregnancy. Lower platelet count at time of delivery is associated with Hypertensive
disorders of pregnancy and thrombocytopenia is found in complicated cases of Hypertensive disorders of pregnancy, affecting maternal and fetal
outcomes
“A PROSPECTIVE STUDY OF MATERNAL AND FETAL OUTCOME IN PREECLAMPSIA AND SEVERE PREECLAMPSIA PATIENTS AT TERTIARY CARE CENTRE”
Authors: Shingade Raginee , Gawandi Prabhakar , Tirankar Vidya
Published: November 2023

Background: Pre-eclampsia and eclampsia is one of the leading causes of maternal and fetal morbidity and mortality. This study was undertaken to
study the effects of pre-eclampsia on the mother and fetus in a tertiary care centre. Method: This study was conducted in Department of Obstetrics
and Gynecology of Dr V.M. Government Medical College Solapur among all antenatal mother visiting the hospital for regular check-up and
planning to delivery at the same institution. In the present study a total of 814 patients with pre-eclampsia was included for nal analysis. Results:
The present study was conducted over a period of 2 years (2020 - 2022) during which a total of 9240 patients delivered at our hospital, of which 814
cases of pre-eclampsia was reported, thus the thus the incidence of pre-eclampsia was 8.8%. Eclampsia was the more common complication seen
among pre-eclampsia patients which was seen among 32% of cases. This was followed by partial HELLP and post-partum hemorrhage seen among
10.6% each. Prematurity was the most common neonatal complication which seen among 35.8% of babies. LBW and IUGR was present in 16%
and 15.6% newborns respectively. 40.26% newborns needed NICU admission. Maternal outcome wa Conclusion: s favorable in most of the
patients with only 2.3% maternal death. The common maternal complications were eclampsia, partial HELLP, and PPH. Most common neonatal
complication was preterm, LBW and IUGR. Neonatal death documented in our study was 9.5%.
ULTRASOUND MORPHOLOGY AND SENTINEL NODE BIOPSY OF AXILLARY LYMPH NODES AS A PREDICTOR OF METASTASIS IN PATIENTS WITH BREAST CANCER
Authors: Gokul B. Ajay , Abhishek M Krishna , Prabhakar A
Published: November 2023

Background:Incidence of 30%. Breast cancer has the ability to spread by three ways: By spread to the lymph nodes in the axilla and then to other
structures in the body ,By spread to different parts of the body through blood and by invading into neighbouring tissues and structures.
Ultrasonography helps in identifying the axillary status, which is safe and reliable. Axillary USG + SNLB will be an effective method in diagnosing
axillary lymph node metastasis in patients with carcinoma breast. Aim: To determine the role of ultrasound morphology of axillary lymph nodes
and sentinel lymph node sampling as a predictor of metastasis in patients with breast carcinoma. Materials and Methods: it is an Interventional
Comparative study done in Department of surgery in Chettinad Hospital and Research Institute for 19 breast carcinoma patients for whom
Preoperative axillary lymph node classication by sonography and Node-to-node correlation between histopathology of clinically palpable
axillary lymph node with histopathology of sentinel node were done to evaluate the efcacy in axillary nodal staging. Results: This study
concluded that SNLB is better than USG axillary lymph node morphology and is the standard of care for axillary lymph node staging in early breast
cancer. The present study were also in line with the earlier reports that, the USG was shown 100 % specicity and 44.44 % sensitivity in the present
study
Knowledge of the Madurese Community-Indonesia Regarding Bioprospection of the Traditional Herb Kamandin Saebo (Glossocardia leschenaultii [Cass.] Veldkamp)
Authors: Purwanti Elly , Nuryady Moh. Mirza , Permana Tutut Indria , Rachmawati Hidajah , Anggraeni Amaliyah Dina
Published: November 2023

The purpose of this study was to describe the knowledge of the Sumenep Madura community (village elders and gatherers) about the Kamandin Saebo (Glossocardia leschenaultii) plant and its utilization. This study uses observational research that aims to observe a fact at a certain time using a descriptional approach model. The research was conducted in the Sumenep-Madura area, East Java Province. The research was conducted in July 2023-August 2023 by observational method. We discussed the results of information regarding the knowledge of the Sumenep people about the existence and growing areas of Kamandin saebo, a literature search regarding the morphological characterization, benefits, or uses of Kamandin saebo in medicine as conveyed by the gatherers. We also found that Kamandin Saebo is of great value. There are 14 healing functions associated with Kamandin Saebo. The Madurese people believe this plant to have many benefits or even cure all diseases.
Protective effects of Mosla Chinensis Maxim against Lung Injury
Authors: Ku Hui-Chun , Lee Shih-Yi , Lin Yung-Kai , Lin Yung-Hsiang , Chiang Chi-Fu
Published: November 2023

Lung fibrosis is a common form of interstitial lung disease. Traditional Chinese medicinal plants have the ability to suppress lung inflammation, but there are relatively few studies on the relationship between Mosla Chinensis Maxim and lung injury. The purpose of this study was to investigate whether Mosla Chinensis Maxim extract (MCME) can alleviate lung injury. This study utilized lung epithelial cells, A549, treated MCME (0.25mg/mL), and analyzed the wound-healing ability, inflammatory cytokines, and cell-cell adheren junctions (E-cadherin). Bleomycin was used to induced lung fibrosis in an animal model, which were then treated with MCME. The results showed that MCME improved cellular repair capacity by 30% compared to the mock group, inhibited IL-8 by approximately 60%, and increased the E-cadherin expression compared to the lipopolysaccharide group. In an animal model, administration of MCME (50 mg/kg) for 14 days alleviated the bleomycin-induced pathological changes in the lungs and fibrosis. This study demonstrated that MCME improved lung injury.
Observability Practice with OODA Principles and Processes
Authors: Kuppam Manoj
Published: November 2023

Observability is essential in numerous areas, including software engineering, business operations, and Information Technology (IT). Created by Colonel John Boyd in a military setting, the OODA (Observe, Orient, Decide, and Act) loop has expanded into a flexible framework for enhancing observability in various areas. This study improves observability and decision-making by applying OODA concepts and procedures in software engineering and business. These domains work together to guarantee smooth workflows in the age of Industry 4.0 and disruptive technology breakthroughs when observability is essential to success. The OODA cycle in software engineering allows engineers to gather information, comprehend context, make logical decisions, and take appropriate action to maximize system security and performance. The “Observe” phase focuses on metrics, logs, events, including data collection, monitoring, and real-time analysis. The “Orient” phase emphasises how crucial anomaly detection and data visualization are to comprehending context. While the “Act” phase handles automation and the implementation of enhancements, the “Decide” phase directs engineers to optimize systems and increase security. From operational indicators to market trends and consumer feedback, the OODA loop helps businesses make data-driven decisions by collecting information during the “Observe” phase. The “Orient” phase helps organizations comprehend customer preferences and market dynamics by analysing data and spotting trends. The “Act” phase makes it easier to implement selected plans, while the “Decide” phase aids in strategic decision-making and resource allocation.
Comparison of Laparoscopy and Open Surgery for Women with Early Stage in low grade Endometrial Cancer
Authors: Winarno Joko , Chamim Chamim , Pratamasari Sarah Miriam Ratna
Published: November 2023

Endometrial cancer is a type of gynecological cancer that becomes a burden to the healthcare system. Laparotomy and laparoscopic surgical techniques are currently the two most common surgical methods for endometrial cancer. The laparoscopic approach was found to be associated with reduced operative morbidity. This study evaluated oncologic outcomes of laparoscopy and laparatomy surgery in the management in early stage of low-grade endometrial cancer. We conducted and observational study of woman diagnosed with International Federation of Gynecology and Obstetrics (FIGO-2018) early-stage endometrial cancer who underwent surgery at the Fatmawati Hospital, Jakarta, Indonesia from 2021-2022. The histopathological types are endometrial cell, well differentiated, no evidence invasion to the cervical/other organ (low grade). A total of 92 patients were treated for stage I endometrial cancer during the study period. Thirty-nine patients (42.4%) underwent laparoscopic surgery and 53 patients (57.6%) underwent laparotomy surgery. The average age of the laparoscopic group was younger than that of the laparotomy group. Comparison of laparotomy and laparoscopy in mean length of operation and amount of blood loss showed no statistically significant difference. The length of stay data showed mean length of stay in laparoscopic group was 3.67 days whereas in the laparotomy group was 5.14 days with significant result statistically. The mean survival of patients one year after the procedure is 49.49 weeks, with the average survival of 1 year in the laparoscopic group was 50.83 weeks and 47.98 weeks in laparotomy group with no statistically significant difference. Laparoscopic has view advantages especially, less blood loss, complication during operation, shorter hospital stay, 1 year survival rate but not significant statistically in this research.