bluuebunny/crossref_metadata_2025 huggingface dataset:
Applying Natural Language Processing to Textual Data From Clinical Data Warehouses: Systematic Review
Authors: Bazoge Adrien , Morin Emmanuel , Daille Béatrice , Gourraud Pierre-Antoine
Published: September 2023

Background

In recent years, health data collected during the clinical care process have been often repurposed for secondary use through clinical data warehouses (CDWs), which interconnect disparate data from different sources. A large amount of information of high clinical value is stored in unstructured text format. Natural language processing (NLP), which implements algorithms that can operate on massive unstructured textual data, has the potential to structure the data and make clinical information more accessible.

Objective

The aim of this review was to provide an overview of studies applying NLP to textual data from CDWs. It focuses on identifying the (1) NLP tasks applied to data from CDWs and (2) NLP methods used to tackle these tasks.

Methods

This review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We searched for relevant articles in 3 bibliographic databases: PubMed, Google Scholar, and ACL Anthology. We reviewed the titles and abstracts and included articles according to the following inclusion criteria: (1) focus on NLP applied to textual data from CDWs, (2) articles published between 1995 and 2021, and (3) written in English.

Results

We identified 1353 articles, of which 194 (14.34%) met the inclusion criteria. Among all identified NLP tasks in the included papers, information extraction from clinical text (112/194, 57.7%) and the identification of patients (51/194, 26.3%) were the most frequent tasks. To address the various tasks, symbolic methods were the most common NLP methods (124/232, 53.4%), showing that some tasks can be partially achieved with classical NLP techniques, such as regular expressions or pattern matching that exploit specialized lexica, such as drug lists and terminologies. Machine learning (70/232, 30.2%) and deep learning (38/232, 16.4%) have been increasingly used in recent years, including the most recent approaches based on transformers. NLP methods were mostly applied to English language data (153/194, 78.9%).

Conclusions

CDWs are central to the secondary use of clinical texts for research purposes. Although the use of NLP on data from CDWs is growing, there remain challenges in this field, especially with regard to languages other than English. Clinical NLP is an effective strategy for accessing, extracting, and transforming data from CDWs. Information retrieved with NLP can assist in clinical research and have an impact on clinical practice.
Exploring the Challenges and Opportunities of Adopting and Using Telemedicine for Diabetes Care and Management: Qualitative Semistructured Interview Study Among Health Care Providers and Patients With Diabetes (Preprint)
Authors: Altabtabaei Rabab , Alhuwail Dari
Published: September 2023

BACKGROUND

Around the world, over half of the global population experiences noncommunicable diseases, resulting in premature death. Health care providers (HCPs) can deliver medical treatment from a distance by using digital advancements such as telemedicine. However, there is a limited understanding of the difficulties and opportunities of implementing telemedicine solutions in different socioeconomic and cultural environments, including Kuwait.

OBJECTIVE

The purpose of this study is to (1) examine the obstacles and benefits of telemedicine in the context of diabetes treatment and management, as perceived by both HCPs and patients with diabetes; (2) investigate the nonfunctional requirements for telemedicine applications used in diabetes care and management; and (3) provide suggestions to enhance the integration and adoption of telemedicine in Kuwait’s health care system for diabetes care and management.

METHODS

The research used a qualitative and exploratory design, with semistructured interviews as the main data collection method. Participants were recruited on the internet through social media platforms due to the COVID-19 pandemic. The results were analyzed using thematic analysis and the Framework Method. The “diffusion of innovation” model was used as a perspective to interpret the findings.

RESULTS

A total of 20 participants were included in this study—10 HCPs and 10 patients with diabetes—all of whom supported telemedicine. The HCPs reported that many diabetes cases could be managed through telemedicine, with only a few requiring in-person visits. Patients with diabetes noted the convenience and time-saving aspect of telemedicine. Both groups recommended the creation of a secure and user-friendly telemedicine system similar to popular social media platforms. Additionally, participants emphasized the importance of telemedicine during the pandemic as a way to prioritize patient safety.

CONCLUSIONS

The results of this study provide valuable insights into the needs and preferences of both HCPs and patients with diabetes in a resource-rich country like Kuwait to embrace telemedicine. The COVID-19 pandemic has changed the way medical care is provided and has pushed both groups to consider digital solutions for ongoing diabetes management and treatment.
Democratic Leadership Style and Organizational Commitment of Academic Staff in Uganda Christian University and Kyambogo University
Authors: Mwebaza Micheal , Kafuuma Samuel S. , Okurut Christine
Published: September 2023

The study establishes the extent to which democratic leadership styles influence organizational commitment of academic staff in Uganda Christian University (UCU) and Kyambogo Universities (KYU). It was guided by three specific objectives; to establish the status of democratic leadership style, status of organisational commitment and finally the influence of democratic leadership style on organisational commitment of academic staff in UCU and KYU. The study utilized Contingence theory of leadership to extensively discuss the democratic leadership style. It was a descriptive cross-sectional survey design hinged on Plato’s deductive reasoning philosophy. The population involved lecturers, heads of departments and deans. These were sampled using simple and purposive random sampling. Data were collected using a self-administered questionnaire and interview guide. Data was analysed at Univariate level using descriptive statistics means and standard deviations. Study hypothesis was analysed using Pearson’s Correlation Co-efficient index. Results revealed an insignificant relationship between democratic leadership style and commitment of academic staff. This study provides at least a facie evidence of how democratic leadership style should be devised to ensure organisation commitment of academic staff. The leaders continued efforts should improve work condition, ensure satisfaction and act in ways that increase loyalty of academic staff to their institutions.
Тепловая жесткость металлорежущих станков. Физические основы. Оценка и управление. Часть 2. Термическая жесткость – инженерные основы оценки и управления
Authors: Кузнецов А.П.
Published: September 2023

С точки зрения требований точности и прецизионности станков рассмотрены основные положения оценок жесткости и их описание в физических процессах упругого деформирования в качестве важного элемента, учитываемого при проектировании металлорежущих станков. Кроме того, рассмотрены вопросы воздействия на станок тепловых факторов, которые также приводят к температурным погрешностям и обусловливают изменение точности станка.
«Киты» успешного производства
Authors: Лаврентьева О.А.
Published: September 2023

Показана важность повышения квалификации инженерно-­технического персонала и рабочих-­сварщиков как одного из основных факторов повышения эффективности работы компаний, использующих новейшее оборудование и высокотехнологичные решения в сварочной отрасли.
On fuzzy congruence relation in residuated lattices
Authors: Khosravi Shoar S. , Borumand Saeid A.
Published: September 2023

In this paper, we characterize some properties of fuzzy congruence relations and obtain a fuzzy congruence relation generated by a fuzzy relation in residuated lattices. For this purpose, two various types of fuzzy relations (regular and irregular) are introduced. In order to obtain a fuzzy congruence relation generated by an irregular fuzzy relation it must convert to a regular fuzzy relation.
On weakly (m, n)−closed δ−primary ideals of commutative rings
Authors: Hamoda Mohammed , Issoual Mohammed
Published: September 2023

Let R be a commutative ring with 1 ≠ 0. In this article, we introduce the concept of weakly (m, n)−closed δ−primary ideals of R and explore its basic properties. We show that a proper ideal I of R is a weakly (m, n)−closed γ ◦ δ−primary ideal of R if and only if I is an (m, n)−closed γ ◦ δ−primary ideal of R, where δ and γ are expansions ideals of R with δ(0) is an (m, n)−closed γ−primary ideal of R. Furthermore, we provide examples to demonstrate the validity and applicability of our results.
Some extensions of the Hermite-Hadamard inequalities for quasi-convex functions via weighted integral
Authors: Bayraktar Bahtiyar , Nápoles Valdés Juan E. , Rabossi Florencia , Samaniego Aylen D.
Published: September 2023

In this note, starting with a lemma, we obtain several extensions of the well-known Hermite-Hadamard inequality for convex functions, using generalized weighted integral operators.
El Estado-nación argentino castigando usuarios de drogas en la última dictadura militar
Authors: González Nicolás Guillermo
Published: September 2023

El presente trabajo se inscribe en el modelo sociocultural para el estudio del “problema de las drogas” haciendo énfasis en el fenómeno “estatal” y “nacional” en la determinación del uso de drogas como comportamiento desviado y tipificado como delito penal. Se trata de una articulación de dimensiones macro y micro en un recorrido histórico alrededor de un fallo judicial durante la última dictadura militar en Argentina. El estudio de este caso nos permitió delinear un perfil sobre el accionar del Estado-nación argentino al castigar penalmente el consumo de drogas articulado al concepto de régimen nacional de alteridad.
Thelma & Louise y Viaje redondo: el viaje de la heroína y la fluidez del género
Authors: Alcántara Islas Omar
Published: September 2023

Este artículo compara y valora dos road movies desde una perspectiva de género sin descuidar el tema de la interseccionalidad, con un acercamiento a la estructura narrativa de ambas películas, para destacar en estas "el camino de la heroína" como itinerario contrapuesto al tradicional "camino del héroe". Este recorrido permite enfatizar el tema del gender al tiempo que subraya algunos aspectos míticos de la ruta heroica.
Editorial
Authors: Cruz Leandro Eligio
Published: September 2023

Siguen existiendo grandes desafíos para las autoridades del gobierno federal, jurisdiccionales y de procuración de justicia, para contar con personal especializado con instrumentos técnico-científicos, y disponer de infraestructura que permitan localizar, individualizar e identificar a las personas desaparecidas en diferentes contextos. Aun cuando pareciera ingenuo o poco realista, uno de los objetivos de esta publicación es hacer un llamado a las autoridades para que antepongan el interés común y el dolor de las víctimas, a sus diferencias políticas o intereses de cualquier tipo. A la sociedad, para que no incurra en la indiferencia y que tenga presente que la tragedia continúa y que, en cualquier momento, la vida nos puede ubicar en el lado de las víctimas o de sus familiares.
Desapariciones
Authors: Pérez-Taylor Rafael
Published: September 2023

Acercamiento al concepto desaparecidos desde una perspectiva de la complejidad humana, para comprender la relación de la violencia con el crimen organizado, pero, sobre todo, cómo se construye y deconstruye la relación entre victimario y víctima, en el contexto del terror, el miedo y el temor, como la base que tiene la sociedad en su conjunto para lidiar con la problemática.
Transición del estudiantado en el Bachillerato a Distancia de la UAEMéx: de adultos a adolescentes
Authors: Montaño Reyes Patricia del Carmen
Published: September 2023

La Universidad Autónoma del Estado de México creó en 2005 el programa de Bachillerato Universitario en la Modalidad a Distancia (BUMAD) para diversificar la oferta educativa y ampliar la atención a la demanda de la sociedad por ingresar a programas educativos de este nivel. En 2012, el plan de estudios del programa se actualizó y reestructuró y actualmente no hay límite de edad para solicitar ingreso. De inicio se enfocó en adultos jóvenes activos en la fuerza de trabajo. Hoy se ve un aumento en las solicitudes de ingreso de recién egresados de secundaria. Contextos que conciben de forma diferente los procesos de enseñanza y aprendizaje promueven la migración de la educación presencial a la no escolarizada, que requiere un perfil específico de sus estudiantes.
Diseño tecnopedagógico en línea como alternativa en el bachillerato presencial de Educación para la Salud en la ENP-UNAM
Authors: Illescas Cruz Karen Itzel , Espinosa Vázquez Olivia
Published: September 2023

Durante la pandemia por el COVID-19 surgió la necesidad de innovar en la educación en línea, por lo que se adoptaron enfoques instruccionales (EI) mediados por tecnología. El objetivo de esta investigación fue implementar dos de ellos (Salmon y HyFlex de Beatty), en el segundo año del bachillerato de la Escuela Nacional Preparatoria (ENP) de la UNAM para la asignatura Educación para la Salud. Se describe la metodología para el desarrollo de una intervención realizada durante siete semanas en un entorno de aprendizaje en línea para la unidad: ‘La prevención en el autocuidado de la salud’. Las experiencias evidencian un aprendizaje situado acorde con el contexto de los estudiantes.
Proteínas del filtrado del cultivo de Mycobacterium bovis promueven apoptosis independientemente de la activación de las caspasas en macrófagos bovinos
Authors: Jimenez Vazquez Itzel Nalleli , Espitia Pinzon Clara , Negrete Abascal Erasmo , Benítez Guzmán Alejandro , Morán Julio , Gutierrez Pabello José Ángel
Published: September 2023

La apoptosis es un proceso que ocurre de manera normal en los tejidos. Se caracteriza por cambios morfológicos en la célula. Las especies del complejo Mycobacterium tuberculosis inducen este fenómeno; en el modelo bovino, se demostró que tanto Mycobacterium bovis como sus extractos proteicos, inducen apoptosis independientemente de la activación de las caspasas, sin embargo, la identidad de las proteínas en los extractos proteicos se desconoce. En este estudio reportamos que, a través de cromatografía de exclusión por peso molecular, se obtuvieron fracciones proteicas con la capacidad de inducir fragmentación del DNA en macrófagos de bovinos independientemente de la activación de la caspasa 3. Asimismo, mediante cromatografía líquida-espectrometría de masas (LC-MS) se identificó la presencia de tres candidatos responsables de la actividad biológica: MPB70, MPB83 y chaperonina de 60 kDa.
Development and Implementation of Transformer Breather Health Monitoring System Using IoT
Authors: Nayak Shivakumar G
Published: September 2023

Abstract: The reliable and efficient operation of power transformers is crucial for maintaining a stable electrical grid. One critical aspect of transformer maintenance is monitoring the health of the transformer breather, which plays a vital role in preventing the ingress of moisture and contaminants. This paper proposes an innovative approach for health monitoring of transformer breathers using the Internet of Things (IoT). By integrating IoT technologies with transformer breather systems, real-time monitoring and analysis of breather conditions can be achieved, enabling proactive maintenance and optimizing the lifespan of the transformer. The proposed IoT-based health monitoring system consists of interconnected breather units equipped with sensors to capture relevant data such as humidity levels, temperature, color of the silica gel, and gas concentrations. These sensors continuously gather data and transmit it to a central monitoring system via wireless communication protocols. The IoT-based health monitoring of transformer breathers offers several advantages over conventional methods. It enables continuous, real-time monitoring, eliminating the need for manual inspections and reducing the risk of unexpected failures.
Legal challenges to the protection of labor rights of refugees in the digital age
Authors: Vakhoneva Tetyana M. , Mykolayets Dmytro A. , Hryshyna Yuliya M. , Yurovska Viktoriia V. , Dyachenko Olha A.
Published: September 2023

The relevance of the problem of protection of the rights of persons granted refugee status is due, in particular, to the fact that the increase in the number of refugees and related political, economic, and social problems confirms the need to reassess and rethink the legal status of this category of persons and to develop a new approach to the analysis and solution of the refugee problem at both international and regional levels. The situation in Ukraine also confirms the fact that not all states are ready to cooperate within the framework of international law and prevent human rights violations, which, in turn, can lead to an increase in the number of refugees. Therefore, the issue of protecting their rights does not lose relevance in scientific research. The purpose of the article is to study the general features of obtaining refugee status and the exercise of the right to work by such persons. The author analyzes the normative sources of international and national law on the relevant topics. In addition, the author examines the practical aspects of the exercise of the right to work by refugees, in particular the problems faced by such persons and suggests possible solutions to existing problems. The leading method used for the study is the formal legal method. Its application determined the feasibility and validity of the study. This method was used in the analysis of legal acts regulating the protection of labor rights of refugees, namely: acts of international law, legislation of the EU member states, Asian countries, as well as national law of Ukraine.
Digital transformation: creating an effective and efficient court in Indonesia
Authors: Amarini Indriati , Saefudin Yusuf , Kartini Ika Ariani , Marsitiningsih Marsitiningsih , Ismail Noorfajri
Published: September 2023

This article discusses digital transformation as an effective and efficient paradigm in court services in Indonesia. The Supreme Court has used digital transformation in court administration by developing an electronic court system or e-Court since 2018. However, procedural law has no legal basis related to electronic trials. The development of online dispute resolution is very fast, while procedural principles regarding due process and neutrality must remain the court's main task. In addition, establishing Internet courts involves three fundamental legal ethical principles: restoring the ceremonial aspects of litigation and creating risk management mechanisms between the legal and technological systems. This study aims to analyze the court's efforts to create an effective and efficient trial in Indonesia. A normative legal method was employed, incorporating various approaches such as the statute, conceptual, and comparative approaches. The research results show that the digital transformation policy was incorporated into the 2010-2035 blueprint of the Supreme Court of the Republic of Indonesia, which has brought about the need to accelerate digital transformation in the justice system. Settlement of civil disputes is carried out using an electronic court (e-court) application with an electronic litigation (e-litigation) mechanism. Meanwhile, the criminal trial was conducted through teleconference media. Still, they have encountered obstacles: limited facilities and infrastructure in conducting the trial, such as internet stability in various regions and limited courtrooms with electronic trial equipment. Need to improve infrastructure and improve the quality of human resources.
La dimensión espacial del bienestar, los cuidados y la vulnerabilidad
Authors: Barañano Margarita , Santiago Jose , Domínguez Marta
Published: September 2023

Se examina la relevancia de los arraigos y las proximidades espaciales en las grandes ciudades iberoamericanas, analizando su protagonismo en los arreglos cotidianos que posibilitan los cuidados y la provisión de bienestar, y con los que se hace frente a situaciones de vulnerabilidad. La perspectiva que se adopta permite atender a estos arraigos locales, que han quedado en un lugar subordinado en la literatura sobre la globalización. Se presta atención tanto a su dimensión material como simbólica y representacional, incorporando, al mismo tiempo, sus transformaciones en el contexto global desde una aproximación multiescalar. El foco de atención son las ciudades de Barcelona, Buenos Aires y Madrid, especialmente sus barrios vulnerables.
Cauces socioespaciales: la segregación y el arraigo en Madrid
Authors: Ariza de la Cruz José , Sorando Ortín Daniel
Published: September 2023

Las sociedades urbanas contemporáneas son cada vez más desiguales y segregadas. En el Sur de Europa, este proceso se combina con la búsqueda de la proximidad a las redes familiares que sostienen el bienestar. En este contexto, este artículo revela la querencia que la movilidad residencial y cotidiana tiene por las proximidades social y geográfica. Para ello, se examina el caso de Madrid en 2018, mediante la combinación de fuentes sobre movilidades y renta. Los resultados muestran que las movilidades priorizan la proximidad espacial. No obstante, eso no significa que los sujetos se muevan a cualquier cercanía, dado que la ciudad está atravesada por fronteras tanto sociales como físicas entre barrios contiguos que definen un mapa de cauces socioespaciales. Además, los procesos de gentrificación influyen en estas prácticas socioespaciales de proximidad, aunque de forma diferente a la que cabría esperar, debido a las características territoriales de los barrios donde suceden.
Sociología y desarrollo territorial: la formación en métodos y técnicas de investigación social de las candidaturas a agente de empleo y desarrollo local
Authors: Sigalat Signes Enric , Aguado i Hernàndez Juli Antoni , Calvo Palomares Ricard
Published: September 2023

La investigación que se presenta aborda, las relaciones entre la sociología y el desarrollo local a través del estudio de la formación en métodos y técnicas de investigación social de las candidaturas al puesto de Agente de Empleo y Desarrollo Local. (AEDL). Se trata de un trabajo empírico que utiliza, por un lado, el análisis documental de materiales institucionales de los procesos de selección a AEDL en la provincia de Valencia en 2019 y la revisión de los planes de estudio de las carreras (licenciaturas, diplomaturas y grados) de dichas candidaturas. Por otro lado, estos resultados se ponen en relación con los requerimientos de formación del personal en activo. Esto sienta la base para la demanda de profesionales formados en sociología, capacitados para enfrentarse de manera integral al proceso de análisis en profundidad de las realidades y desafíos del ámbito local, lo que puede fortalecer y revalorizar nuestra disciplina.
Correlation Between Serum Magnesium & Zinc with Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) In Patients with Metabolic Syndrome
Authors: Manik Khaleel Ahmed , Joice P P Sheela , T K Jithesh , A Jagadal Imran , Prathap. A Sudhindra , M P Basheer
Published: September 2023

Metabolic syndrome (MS) increases cardiovascular disease and death risk. Many studies have found a link between vascular inflammation and metabolic disorders. Discovering unique and specific blood-based indicators for vascular inflammation, particularly in metabolic syndrome related to obesity, such as (lipoprotein-associated phospholipase A2) and Lp-PLA2, could provide valuable assistance in identifying individuals at an elevated risk for cardiovascular incidents. Lp-PLA2 has been implicated in metabolic dysregulation, playing a crucial role in the onset of microvascular dysfunction and the exacerbation of oxidative stress. Lp-PLA2 is essential in the pathogenesis of atherosclerosis and may be used as a biomarker to predict future cardiovascular events. The study comprised 200 participants categorized into two groups: individuals diagnosed with MS (Metabolic Syndrome) (Test, n = 100) and those without MS (controls, n = 100). The serum activity levels of hs-CRP and Lp-PLA2 were measured and subsequently analysed for correlation with micronutrients (magnesium (Mg) and zinc (Zn)) and lipoprotein markers (Ox LDL, Apo-A1, and Apo-B). The study showed a significant correlation between Lp-PLA2 and the Mg level of patients with MS, whereas Hs-CRP did not exhibit a significant correlation. The test population did not exhibit a noteworthy elevation in oxidized LDL level, despite the presence of inflammatory changes as indicated by the level of Lp-PLA2. A significant correlation was observed between the Zn level in patients with MS and Lp-PLA2, whereas Ox LDL did not exhibit a significant correlation. The current study revealed a significant link between Mg and Zn and CVD risk in the Kerala population. The study found elevated levels of LpPLA2, an emerging biomarker for cardiovascular risk, in people with MS
Comparative Analysis of Various Sinusoidal Pulse Width Modulation Techniques
Authors: Bhattacharya Satabdi , Samanta Susovon
Published: September 2023

This paper examines several sinusoidal pulse-width modulation (SPWM)
methods for single-phase H-Bridge inverters. Various SPWM strategies
have been proposed in the literature up to this point. With PWM, the
inverter’s output voltage can be changed, so large filters are no longer
needed. The conventional and modified SPWM techniques are described in
this paper. Total Harmonic Distortion (THD), switching losses,
fundamental component values, and dead time losses are used to compare
the effectiveness of these SPWM methods. A MOSFET-based H-bridge
inverter circuit is developed to verify different SPWM methods. The
design of a transformer-based filter circuit for a single-phase H-bridge
inverter is also included in this study. The hardware implementation
uses the Delfino TMS320F28379d digital signal processor (DSP). This
article explains how to integrate MATLAB-Simulink with the TMS320F28379D
DSP processor. The hardware results, as well as the programming
approach, are presented in this paper.
Respiratory Syncytial Virus incidence and typing in the last 6 seasons in the north of Spain (Asturias). Genetic characterization during the SARS-Cov-2 pandemic
Authors: melon Santiago , Rojo Susana , Pérez-Martínez Zulema , Alba José María González , Boga Jose , Ochoa-Varela Cristina , Álvarez Maria Agustina Alonso , Fonseca Carmen Pérez , Clemente Marta María García , Rodriguez José Gutierrez , García Estibaliz Garrido , Rodríguez-Pérez Mercedes , Alvarez-Arguelles Marta
Published: September 2023

Respiratory syncytial virus is associated with lower respiratory tract
infections. As several types and genotypes can circulate at the same
time, genomic characterisation is important for timely epidemiological
control and treatment measures. In the last 6 seasons (2017-2023),
191236 nasopharyngeal swabs were processed for respiratory viruses. The
incidence of RSV reached 7% in the pre-pandemic season. RSV was most
frequent in children under 5 years of age (12.6%), but was also
significant in those over 70 years of age (5.63%). The measures taken
to control SARS-Cov2 infection were useful for RSV control and the
incidence decreased to 1.8%, but caused a change in the types.
Pre-pandemic, the majority circulating types were RSV-B/RSV-B/RSV-A and
in pandemic it was RSV-B/RSV-B. In the last season, RSV-B and RSV-A were
detected in the same proportion. Genetic characterization showed three
new clades. This has been taken into account in order to take the
correct measures.
Pexidartinib Triggers the Risk of Drug-drug Interactions by Inhibiting UDP-glucuronosyltransferase in vitro
Authors: Liu Yong , Wang Zhen , Lv Xin , Yin Hang , Jiang Lili , Li Wenli
Published: September 2023

Pexidartinib is the first FDA approved drug for adult patients with
tenosynovial giant cell tumor that are not amenable to improvement with
surgery. In vitro data has showed pexidartinib is likely to
inhibit UDP-glucuronosyltransferase (UGT) 1A1 at clinically relevant
concentrations. However, the effects of pexidartinib against other UGT
have not been fully characterized. Therefore, this study purpose to
investigate the inhibitory effects of pexidartinib against UGT, as well
as to quantitatively evaluate drug adverse reactions by UGTs inhibition.
Our results indicated that pexidartinib exhibited potent inhibition of
UGT1A1, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, and 2B15, with a range
of IC values of 0.97-20.02 μM. Pexidartinib displayed
competitive inhibition towards UGT1A1, UGT1A6, UGT1A7 and UGT1A9, while
mixed inhibited UGT2B15. The K values for them
were calculated to be 4.27 ± 0.28 μM, 1.72 ± 0.12 μM, 1.67 ± 0.11 μM,
0.65 ± 0.13 μM, and 2.37 ± 0.45 μM, respectively. Co-administration of
pexidartinib at the clinically approved dose (400 mg twice daily) with
drugs primarily cleared by UGT1A1, UGT1A6, UGT1A7, UGT1A9, and UGT2B15
would likely result into increase of drug-drug interactions risk.
Belowground carbon transfer from sunlit pines to shaded oaks
Authors: Livne-Luzon Stav , Fox Hagar , Cahanovitc Rotem , Rapaport Alon , Klein Tamir
Published: September 2023

Although gaining much attention in recent years, it is unclear whether
mycorrhizal fungi distribute meaningful amounts of resources among trees
in ways that increase the fitness of the receiving trees. To this end,
we used shaded and non-shaded pairs of inter- and intra-species Pinus
halepensis and Quercus calliprinos saplings growing outdoors in forest
soil. Carbon transfer was measured using pulse labeling with 13CO2 and
the mycorrhizal community of each tree was identified by DNA barcoding.
The effects of belowground connections were examined by tree performance
and Non-Structural Carbohydrates (NSC) pools. Although we did not
observe any growth benefits, shaded recipient oaks exhibited higher
levels of root NSC compared to their control counterparts, which were
not connected belowground. This finding suggests a potential benefit of
establishing below-ground connections. We also show that non-shaded
pines connected to shaded oaks were depleted of their starch pools,
suggesting a possible cost of the tree-fungi-tree interaction.
Additionally, we monitored the carbon (C) flow from a 13CO2 labeled
donor pine tree to the final recipient oak tree and were able to
demonstrate C transfer from pines to shaded oaks. Finally, we were able
to identify the main fungal symbionts interacting with pines and oaks.
Our results link specific mycorrhizal species to belowground C transfer
and suggest C-driven fitness costs and benefits to the trees.
Modification of the Ni-NiO-oxidant system by thermo-chemical oxidation with accelerated growth of the p-type dielectric oxide layer, by the action of substituted V2O5 on the system
Authors: Purenovic Jelena , Purenovic Milovan
Published: September 2023

Nickel is covered with very thin oxide film and is stable against corrosion under normal conditions. Nickel, as Ni-NiO-oxidant system, can make much thicker (even a thousand times) and more corrosion unstable oxides. With certain new oxidation process parameters, nickel can undergo so-called accelerated oxidation. The subject and goal of this work is to find the most favorable conditions for performing of accelerated - catastrophic Ni oxidation process, when substitution of V2O5 is carried out into NiO (2V??? (Ni)), with significant electron concentration increase and oxygen surplus. Unlimited main and secondary charge carriers transfer is significantly facilitated if oxide film with non-stoichiometric composition and defects is formed. The aim is to avoid compact oxide film formation by chemical-thermal treatments and to obtain porous and defective NiO. By using oxidized system Ni - NiO - oxidant in glass, ceramics and evaporated metal technology, extraordinary usable value of this work is ensured.
Overview of non-invasive sampling methods used in intensive swine farming
Authors: Glisic Dimitrije , Veljovic Ljubisa , Milovanovic Bojan , Ninkovic Milan , Maletic Jelena , Kureljusic Branislav , Milicevic Vesna
Published: September 2023

Monitoring the health of swine herds is essential to ensure good manufacturing practices. Traditionally, active and passive surveillance on farms involved invasive sampling methods, where specific animals were selected, restrained, and sampled. However, with the increasing intensity of swine production, alternative methods for effective herd surveillance became necessary. Non-invasive sampling provides a convenient and cost-effective approach to monitor the entire herd without compromising animal welfare, while still obtaining suitable samples for testing. Oral fluids have been widely used in both human and livestock health surveillance for various viral pathogens, including significant diseases. Nasal wipes (NW) utilize different cloth materials soaked in phosphate-buffered saline (PBS) or tissue culture medium with antibiotics and antimycotics to sample for swine influenza virus (SIV). Udder skin wipes (USW) offer an alternative method to assess the health status of piglets in a litter. During routine procedures such as tail docking and castration, a mixture of blood and serum can be collected, known as process fluids (PF), which has proven successful in monitoring herds for the presence of porcine reproductive and respiratory syndrome virus (PRRSV). Furthermore, air sampling has emerged as a novel technique to detect pathogens in various farming systems and animal species. This method offers the advantage of obtaining diagnostic samples without direct animal contact. By employing these non-invasive sampling methods, swine producers can implement effective surveillance strategies while maintaining animal welfare standards and obtaining reliable diagnostic information.
Simultaneous Bilateral Anterior Shoulder Fracture Dislocation Following a Seizure: A Case Report and Review of Literature
Authors: Alrushaydan Ayman , Alsayed Mokhtar , Alnefaie Amer
Published: September 2023

Simultaneous, Bilateral anterior fracture-dislocation of the shoulders is very rare complication of generalized seizures. most cases attributable to major trauma. Seizures and electric shock are a common cause of fractures and dislocations of shoulder although these are most commonly posterior injuries. We present interesting case report of diagnosis and treatment of a patient with bilateral anterior shoulder fracture dislocations following a seizure.
LOS INCENDIOS FORESTALES AFECTAN LAS PROPIEDADES FÍSICAS DEL SUELO
Authors: Muñoz de Páez Betsy Carolina , Palencia Arias Génesis Aurora , Henríquez Leonellys Maria Chirino , Mogollón Sandoval José Pastor
Published: September 2023

El objetivo fue evaluar el efecto del fuego sobre las propiedades físicas de un suelo afectado por un incendio forestal en el cerro “Corumo”, Sierra de San Luís, Estado Falcón-Venezuela, siendo esta un área estratégica para la protección del ambiente y del Sistema Hidrológico “El Falconiano”. Fueron delimitadas tres áreas: a) Plantación Afectada por el incendio forestal (PA), b) Plantación no Afectada por el incendio forestal (PNA) y c) Bosque Natural (BN). En cada área se seleccionó una parcela de 0,1 hectáreas donde se realizó el muestreo de suelos de manera aleatoria, se tomaron muestras disturbadas y no disturbadas para determinar textura, estabilidad de los agregados, densidad aparente (Da) y humedad gravimétrica (H), también se evaluó la infiltración en campo. Los resultados indican que textura y humedad del suelo no fueron afectadas por el incendio forestal, pero la estabilidad de los agregados de suelo se redujo. La densidad aparente disminuyó y la velocidad de infiltración incrementó en el suelo afectado, indicando que estas propiedades fueron favorecidas por el fuego en suelos degradados por sobrepastoreo. El impacto del fuego sobre las propiedades físicas del suelo a corto plazo puede ir en dos direcciones, afectando negativamente algunas propiedades y mejorando otras.
IMPACTOS AMBIENTAIS NA ÁREA DE PRESERVAÇÃO PERMANENTE (APP) DO RIO GURGUÉIA NO PERÍMETRO URBANO DO MUNICÍPIO DE SÃO GONÇALO DO GURGUÉIA – PI
Authors: Barros Maciel Estefani , Nunes Gomes Patrine , Aparecida Costa Lima Marina , Thainy Rocha Porto Stéfany , De Souza Carvalho Cecília , Carvalho Maia Juciely
Published: September 2023

O crescimento populacional ocasionou inúmeros problemas ao meio ambiente, intensificada pela superexploração dos recursos naturais de forma desordenada. O objetivo da pesquisa foi identificar os impactos ambientais na Área de Preservação Permanente (APP) do rio e propor medidas mitigadoras. A pesquisa foi realizada no perímetro urbano de São Gonçalo do Gurguéia – PI às margens do rio Gurguéia. O método para a avaliação dos impactos ambientais foi a Matriz de avaliação de impactos derivada de Leopold. Neste, os impactos ambientais foram identificados mediante visita in loco para obtenção dos dados, percorrendo as margens do rio. A maioria dos impactos identificados na APP foram classificados como de caráter negativo, sendo estes relacionados aos aspectos ambientais: disposição de resíduos sólidos diversos, lançamento de efluentes domésticos, ausência de canais de escoamento de águas pluviais, supressão da vegetação. Estudos relatam que a cobertura vegetal possui papel relevante por auxiliar na redução dos impactos ambientais. O diagnóstico permitiu constatar que a área se encontra em estágio de degradação ambiental devido aos impactos que afetam o meio físico, biótico e antrópico. Com isso, é possível propor medidas mitigadoras para serem adotadas pelos órgãos competentes para a adoção de ações preventivas e corretivas para a recuperação da APP.
Faktor-faktor yang Mempengaruhi Jumlah Penyerapan Tenaga Kerja Industri Mikro Kecil di Indonesia
Authors: Habibi Isra , Marta Joan
Published: September 2023

This study aims to identify and analyze the factors that influence the absorption of micro and small industrial workers in Indonesia. This study uses secondary data sourced from the Indonesian Central Bureau of Statistics with the research variables grouped into two parts, namely the dependent variable which in this study is defined as the absorption of small micro-industrial workers and the independent variables consisting of capital, wage levels and output values. This study uses panel data regression analysis with the selected method, namely the Fixed Effect Model (FEM). The results of the research in the analysis of the micro-industry equation show that capital and wage levels have a positive and significant effect on the absorption of micro-industrial labor in Indonesia, while the output value has a positive and insignificant effect on the absorption of micro-industrial labor in Indonesia. The results of the research in the small industry equation analysis show that capital has a positive and insignificant effect on the absorption of small industry workers in Indonesia, while the wage rate and output value have a positive and significant effect on the absorption of small industry workers in Indonesia.
Fibras antimicrobianas a base de nylon y nanoparticulas de cobre: evaluación preliminar
Authors:   CONACYT - Unidad de Materiales, Centro de Investigación Científica de Yucatán, Cruz- Delgado V. J , Ávila Orta C. A ,   Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada, Soriano- Corral F. ,   Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada, Valdez- Garza J. A ,   Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada, Cabello- Alvarado C. J ,   Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada, Vaca- Padilla F. ,   Departamento de Biología, Universidad de Guanajuato, Anaya- Velázquez L. F ,   Departamento de Biología, Universidad de Guanajuato
Published: September 2023

La persistencia de infecciones causadas por bacterias dentro de los hospitales (infecciones nosocomiales) aún sigue siendo un factor determinante en la recuperación de muchos pacientes en México y otros países. Diversos estudios sugieren que esta contaminación cruzada puede tener origen en la indumentaria del personal (médicos y enfermeras), ropa de cama y artículos de uso común. Hasta el momento, no existen alternativas eficaces para contrarrestar esta incidencia, dado que las opciones disponibles en el mercado actual son de poca duración y suelen perder su eficiencia después de algunos ciclos de lavado. Debido a lo anterior, se ha propuesto el uso de nanoparticulas metálicas para prevenir el crecimiento de diversos microorganismos patógenos, mezcladas con un polímero de uso textil común como el nylon, para obten er fibras bi-componente con una configuración núcleo/coraza, donde las partículas se localizan únicamente en la superficie de la fibra. Los resultados de evaluación antimicrobiana demuestran que con 100 mg/mL de nanoparticulas de cobre (nCu) se puede inhibir el 100% del crecimiento de diversos microoganismos, mientras que se requiere de 0.5% en peso de nCu en las fibras para prevenir el crecimiento de hasta un 50% de diferentes microorganismo patógenos, con tiempos de contacto cortos
Content of Polyphenolic Compounds and Biological Activity of Berries, Leaves and Flowers of Crataegus L.
Authors: Żurek Natalia , Kapsuta Ireneusz , Cebulak Tomasz
Published: September 2023

In this study, the berries, leaves and flowers of six species of hawthorn (Crataegus L.) were evaluated for bioactive compounds (polyphenols, flavonoids, procyanides, UPLC profile) and their antioxidant activity (ABTS•+, CUPRAC, iron ion chelation, scavenging O2
·- and OH− radicals). Most of the analyzes were performed for the first time for this material. The content of bioactive compounds differed significantly both between the species and morphological parts studied. In particular, the highest content of polyphenols was determined for hawthorn berries (301.65 to 387.16 mg/100 g d.w.), including the highest concentration for C. x subsphaericea. The polyphenolic profile of this species was dominated by flavan-3-ols, with procyanidin trimer, (-)-epicatechin and procyanidin dimer being the most numerous. Hawthorn berries were also characterized by the highest antioxidant activity, among which the species C. laevigata x rhipidophylla x monogyna showed the strongest antiradical activity (0.91 mmol TE/g and 294.96 µg/ml for tests with the ABTS•+ and OH− radical, respectively) and chelating iron ions (700.28 µg/ml). In conclusion, the results explain the traditional use of hawthorn in folk medicine and indicate a potentially new wider application as a source of natural antioxidants in the design of functional foods.
Risk Profiling of Exposures to Potentially Toxic Metals PTM(S) Through Noodles Consumption. A Case Study of Human Health Risk Assessment
Authors: Jakkielska Dorota , Frankowski Marcin , Kurzyca Iwona , Ziołafrankowska Anetta
Published: September 2023

This study aimed to quantify levels of the toxic heavy metals metalloid arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in commercially available noodles. Analysis was performed via the acid microwave digestion method followed by inductively coupled plasma mass spectrometry (ICP-MS). Furthermore, the potential health risks resulting from the consumption of noodles by polish consumers were evaluated using the estimated average daily intake of heavy metals (ADIHMs; µg·kg−1 bw·day−1). Additionally, to assess the potential health consequences due to noodle consumption, the total hazard quotient (THQ) and cancer risk (CR) were calculated. The average contents of Pb, As, Cd, and Hg in instant noodle samples were determined as 9.241, 8.483, 29.39, and 1.661 µg·kg−1, respectively. THQ values for heavy metal toxicity were found to be below 1, indicating that the consumer is not exposed to carcinogenic health risks associated with the analyzed metals. Additionally, the rank order of max THQ was Pb < Cd < As < Hg, and the mean THQ was Pb < Hg < As < Cd, while both the max and mean CR rank orders were Pb < Cd < As.
Lyophilized Kale (Brassica oleracea L.) Leaves as an Enhancing Component in Gluten-Free Bread
Authors: Korus Anna , Witczak Mariusz , Juszczak Lesław , Korus Jarosław
Published: September 2023

The objective of the research was to assess the impact of powdered kale (Brassica oleracea L. var. acephala) on the properties of starchy gluten-free dough and bread. Kale lyophilisate was added to the recipe as 3%, 6%, or 9%, replacing the starch. The addition of the kale resulted in a decrease in the dough's strength despite the optimisation of the water content. The presence of kale lyophilisate reduced the volume of the loaves, in comparison with control, resulting in a decrease in crumb porosity and pore density, and an increase in the quantity of large pores. The addition of lyophilised kale at all levels resulted in an increase in taste acceptability, while the 6 and 9% kale decreased the acceptability of the other sensory parameters. The presence of the kale lyophilisate led to a reduction in crumb hardness on individual days of storage compared to the control sample, and the decrease was greater the more kale powder was added to the recipe. Bread with the highest concentration of the kale lyophilisate showed lower enthalpy of retrograded amylopectin decomposition in subsequent days of storage.
The Schooner Enterprise: a Forgotten Key West Murder Case
Authors: Jarvis Robert M.
Published: September 2023

In 1859, Key West found itself transfixed by a sensational criminal trial. Styled United States v. Carcer, Eloy, and Davis, and presided over by William Marvin, the island's legendary federal judge, the case involved a mutiny-murder aboard the slave ship Enterprise. Although famous in its day, the tale has been all but forgotten due to the Great Key West Fire of 1886, which destroyed nearly every record of the affair.
Great Britain and the Confederacy
Authors: Slinger Michael J.
Published: September 2023

This essay describes the efforts of the Confederate States of America to convince Great Britain to support its secession from the United States. Although the South's leaders were confident that Britain's need for cotton would lead it to become an ally, numerous factors—including the British public's aversion to slavery—contributed to the country remaining neutral.
Property Damage Assessment Methods and Models due to Armed Aggression
Authors: Drapikovskyi Oleksandr , Ivanova Iryna
Published: September 2023

The paper deals with the conceptualization of the gross development value to assess direct damages and the restoration needs of lost, destroyed and damaged real estate as a result of armed aggression. A critical review of the existing practice of assessing property damage has been carried out. The measurement units of direct damages and the restoration needs, the evidence base used, the valuation methods for the determination of property damage are analyzed. The methodological potential of compounded cash flow models and the criteria for assessing their reliability is substantiated. A system of valuation models for calculating direct damages and restoration needs is proposed, depending on the category of real estate and market conditions at the valuation date. These valuation models are relatively simple to implement and understandable to the intended users of property damage valuation reports.