bluuebunny/crossref_metadata_2025 huggingface dataset:
SENESCENCE NEW FRONTIERS - SENNET CONSORTIUM
Authors: Niedernhofer Laura , Montes Viviana Perez
Published: December 2023

Senescence is a cell fate triggered by stress, activating signaling cascades that stably arrest the cell cycle, thereby preventing mutagenesis and cancer. Senescent cells are critical for wound healing and other physiological processes, during which they secrete a host of factors that remodel tissue and attract immune cells, which are responsible for removing the senescent cells. However, with age and immune dysfunction, senescent cells accumulate and are established to play a causal role in aging and most age-related diseases, largely through their secretome that drives chronic sterile inflammation. Senescent cells have proven tractable as drug targets, potentially affording novel geroscience approaches to treat a variety of age-related diseases, including Alzheimer’s disease. To optimize this opportunity much more must be learned about senescent cells. This is a challenge as there are no specific biomarkers to detect or isolate senescent cells. Furthermore, senescent cells are anticipated to be highly heterogeneous based on cell lineage, the cause of senescence, their secretome, and tissue context. This challenge sparked the creation of the SenNet Consortium, an NIH Common Fund effort involving hundreds of scientists across the globe charged with creating a 4D atlas of senescent cells in 18 healthy human tissues across human lifespan, using mice and perturbations to inform the mapping. The speakers in this session will define the goals of SenNet, the scientific opportunities and challenges, the novel technologies applied, and the anticipated deliverables including large public datasets and innovative search and visualization tools.
SINGLE-CELL AND SPATIAL OMICS FOR MAPPING CELLULAR SENESCENCE IN HEALTH, AGING AND DISEASE
Authors: Fan Rong
Published: December 2023

NIH SenNet consortium aims to dissect the heterogeneity of senescent cells (SnCs) and map their impact on the microenvironment at a single cell resolution and in the spatial tissue context, which requires the implementation of an array of omics technologies to comprehensively identify, characterize, and spatially profile SnCs across tissues in humans and mice. These technologies are broadly categorized into two groups –single cell omics and spatial mapping. To achieve single cell resolution and overcome the scarcity of SnCs, high-throughput single-cell and single-nucleus transcriptomic techniques have become a mainstay tool for surveying tens of thousands of cells to identify transcriptional signatures in rare cell populations, enabling discovery of potential new SnC biomarkers. Novel single cell mass spectrometry methods are developed for unbiased discovery of proteomic signatures of SnCs. A hallmark of SnCs is the senescence-associated secretory phenotype (SASP), which requires the use of proteomics, secretomics, metabolomics and lipidomics, especially SASP-associated extracellular vesicles, for comprehensive characterization of SAPS. High resolution molecular and cellular imaging of gene expression (e.g., MERFISH) or protein markers (e.g., CODEX) is critical for the study of SnCs in the large-scale tissue context. NGS-based spatial omics sequencing is poised to bridge the gap to realize both genome scale and cellular resolution in mapping SnCs in tissue. Novel technologies such as Seq-Scope and Pixel-Seq developed within SenNet further enabled subcellular resolution. SenNet investigators also developed spatially resolved epigenome and multi-omics sequencing techniques to link transcriptional or proteomic phenotype of SnCs to epigenetic mechanism. Further integration with high-resolution imaging makes spatial omics the crucial linchpin in connecting mechanistic underpinnings and molecular signatures with morphological features and spatial distribution. All these are critical for the construction of a map of SnCs and associated niches in the native tissue environment implicated in human health, aging, and disease, which is one of the main goals of the SenNet consortium.
BUILDING A HUMAN REFERENCE ATLAS
Authors: Bueckle Andreas
Published: December 2023

The Human Reference Atlas (HRA, https://humanatlas.io) is a comprehensive, high-resolution, three-dimensional atlas of all the cells in the healthy human body. The HRA provides standard terminologies and data structures for describing specimens, biological structures, and spatial positions linked to existing ontologies. In this talk, we will present a high-level overview of the major components of the HRA--including 67 anatomically correct 3D Reference Objects for 29 organs and 31 Anatomical Structure, Cell Types, and Biomarker (ASCT+B) Tables--and the tools to explore, use, author, and review the HRA--including the Registration User Interface, the Exploration User Interface, the ASCT+B Reporter, and the HRA Organ Gallery in virtual reality. We welcome experts and practitioners to join the monthly WG meetings (sign up at https://iu.co1.qualtrics.com/jfe/form/SV_bpaBhIr8XfdiNRH), to explore and contribute to this effort, and to provide feedback on the evolving HRA from diverse perspectives.
LOCAL FAMILY AND FRIEND TIES AND THEIR RELATIONSHIP TO SOCIAL SUPPORT AND STRAIN AMONG OLDER ADULTS
Authors: Choi Won
Published: December 2023

Family members and friends who live nearby are likely valuable sources of support for older adults. At the same time, local family and friend ties may also be a source of strain as spatial proximity to close ties can generate more intense interactions. Using data from Round 3 (2015-2016) of the National Social Life, Health, and Aging Project (NSHAP) (N=3,615), this study examines how local family and friend ties reported in older adults’ social network roster are associated with instrumental and emotional support and social strain among community-dwelling older adults aged 50 and older. Results from ordered logistic regression models show that having a local friend tie is associated with higher levels of instrumental and emotional support from friends and lower levels of instrumental and emotional support from family. Having a local family tie, on the other hand, is associated with higher levels of instrumental support from family and lower levels of emotional support from friends. Having a local family tie is not related to emotional support from family or instrumental support from friends. Results also indicate that having a local friend tie increases the odds of reporting that friends make too many demands (i.e., higher friend strain) whereas having a local family tie is not a predictor of family strain. Together, results suggest that spatial proximity to friends and, to a lesser degree, family members are linked to how older adults experience social support and strain.
RACIAL AND ETHNIC VARIATIONS IN THE EFFECTS OF KNOWING ABOUT ONE’S DIAGNOSTIC LABEL OF DEMENTIA ON SOCIAL SUPPORT
Authors: Amano Takashi , Halvorsen Cal , Kim Seoyoun , Reynolds Addam , Scher Clara , Jia Yuane
Published: December 2023

Theoretically, knowing about one’s diagnostic label of dementia may increase a chance to receive necessary social support. However, empirical evidence especially regarding the racial/ethnic variations in the effects of diagnostic labeling on provision of social support is lacking. Data from the Health and Retirement Study (HRS, 2000-2018) were utilized to examine variations in the effects of knowing about a diagnostic labeling. A total of 7,192 person-year observations who had dementia were included in the analysis. Knowledge about a diagnostic label of dementia was measured by asking whether a doctor told the person that he/she had dementia. Formal and informal types of received social support were measured. Regression analyses with inverse probability weighting were performed. A moderating role of race/ethnicity was examined by conducting subgroup analyses. Knowing about a diagnostic label significantly increased likelihood of having more informal (OR = 1.58, p < 0.001, 95% CI = [1.34, 1.86]) and formal support (b = 0.09, p < 0.001, 95% CI = [0.05, 0.13]). The significant effect of a diagnostic label on formal support was not observed among non-Hispanic Black (b = 0.07, p = 0.086, 95% CI = [-0.01, 0.15]) or Hispanic (b = 0.07, p = 0.152, 95% CI = [-0.03, 0.16]) individuals. Results suggest that knowing about a diagnostic label of ADRD may increase informal and formal social support. However, the beneficial impacts may not be salient for non-Hispanic Black and Hispanic individuals. Strategies to maximize the beneficial effects of diagnostic labeling should be identified to address racial/ethnic disparities.
A RESEARCHER–PRACTITIONER COLLABORATION ON MEASURING SUCCESS IN ELDER MISTREATMENT INTERVENTION
Authors: Burnes David , Kimball Patricia , Cox Polly , Harnish Kathryn , Ayoob Carol , Connolly M T , Rogers Geoff , Lewis Stuart
Published: December 2023

One of the major barriers to conducting elder mistreatment intervention research is a lack of understanding on how to measure outcomes of success. Within the context of the RISE project, this presentation will describe a highly collaborative process between researchers and RISE practitioners (supervisor and advocates) to develop a measurement instrument that meets validated research standards as well as the needs of practitioners who work directly on elder mistreatment cases and are responsible for administering the tool. Informed by ecological-systems, relational, and client-centered perspectives, RISE is a conceptually driven, evidence-based, community-based elder mistreatment response program that works with older adults at risk of or experiencing EM, as well as their alleged harmers, their relationship, and their surrounding social support systems. This presentation will describe the process of developing an appropriate measurement tool through weekly meetings over a 6-month period, from a starting point characterized by widely discrepant instrument expectations across the researcher-practitioner dyad toward an ending that achieved mutual agreement. This process required high levels of honesty, openness, patience, and humor among members. The final version of the measurement tool will be presented, which measures intervention outcome constructs of older adult social support, self-efficacy, life satisfaction, and perceived stress, as well as practitioner-client working alliance.
INFECTION CONTROL ADVOCATE AND RESIDENT EDUCATION (ICARE): PERSON-CENTERED INFECTION PREVENTION FOR QUALITY CARE
Authors: Cervantes Diana
Published: December 2023

Applying infection prevention and control (IPC) measures while ensuring person-centered care (PCC) remains a major challenge in nursing homes. PCC focuses on resident rights to engage and empower nursing community residents, families, advocates, and staff to deliver quality care. To address this gap, The Infection Control Advocate and Resident Education (ICARE) program was developed for nursing home residents and families. ICARE is a step-based program which begins with educating participants on IPC and resident rights through seven web-based modules. The program encourages support and collaboration of nursing home advocate organizations including the long-term care ombudsman program, quality care organizations, and public health departments to assist residents and families in becoming more engaged and empowered in quality care beginning with infection prevention and control. Utilizing ICARE program materials, participants progress to engagement by learning how quality care is provided in their nursing home community, with the goal of empowering residents to actively participate in quality care improvement through quality improvement projects. The ICARE Program assists nursing home advocate organizations to identify opportunities to incorporate elements of infection control, quality care, and resident rights in current procedures and activities. The overall program design and theory of the ICARE program will be presented to provide a foundation for the creation of similar programs.
EMOTIONAL CO-REGULATION IN YOUNGER AND OLDER COUPLES’ DAILY LIVES: THE ROLE OF PSYCHOLOGICAL AVAILABILITY
Authors: Meier Tabea , Huber Zilla , Martin Mike , Horn Andrea
Published: December 2023

Close relationships represent an important context for aging. Romantic partners can provide important resources for day-to-day individual and relational functioning by regulating their emotions together. Emotional co-regulation attempts are, however, not always successful and may depend on situational factors such as psychological availability, i.e., an individual’s current ability to be open and attentive to their partner’s needs. The present study examined emotional co-regulation in the daily lives of younger (N=62; 18-33 years) and older (N=56; 57-87 years) couples, focusing on the particular role of psychological availability. In a 21-day experience-sampling study, both participating partners reported their momentary emotional experiences, perceived psychological availability, relationship quality and (co)-regulation strategies three times a day. Results from dyadic multilevel modeling revealed that older and younger participants did not differ in the strategies they used to regulate their own and their partners emotions, but older couples showed greater emotional synchrony (i.e., coordinated changes between partners’ emotional experiences) throughout the study. When partners experienced greater psychological availability, they used more adaptive (e.g., positive humor, responsive touch) and fewer maladaptive (e.g., ruminative brooding) emotion regulation strategies. They also experienced more positive emotions and greater relationship quality when they were more psychologically available, and these associations were particularly evident among younger couples. The findings suggest that older partners were more attuned to each other’s emotions, but that their co-regulation depended less on psychological availability. This potentially speaks to more automatic co-regulation among older couples and opens the door for further investigations of situational factors that impact successful co-regulation.
DYADIC HEALTH SCIENCE IN GERONTOLOGY: RECENT ADVANCES AND INTERDISCIPLINARY PERSPECTIVES
Authors: Martire Lynn , Lyons Karen , Proulx Christine
Published: December 2023

Close others impact health in profound ways, and many of the critical pathways can only be understood by examining the dynamics that emerge between two people. This symposium will present new theoretical and methodological advances in dyadic health science, and invite discussion of differing perspectives on the scope of dyadic research. Dr. Wilson will overview the essential components of rigorous dyadic health research and explain the range of approaches used to define dyadic research, setting the stage for the cutting-edge work described in the subsequent presentations. Drs. Novak and Yorgason will discuss the importance of matching research questions with dyadic data and how to best model congruence/similarity, difference scores, accuracy or bias, and idealization between partners. Dr. Pauly will describe a recently proposed developmental-contextual model of couple synchrony, and present findings from research using a smartwatch and smartphone system (DyMand) that captures dyadic interactions. Dr. Polenick will present findings from research examining effects of incongruent and discordant health conditions within older couples on depressive symptoms. Dr. Christine Proulx, an internationally recognized scholar of close relationships in late life, will offer perspective on these advances and critical future directions for the field. This is a Dyadic Research on Health and Illness Across the Adult Lifespan Interest Group Sponsored Symposium.
A DEVELOPMENTAL–CONTEXTUAL MODEL OF COUPLE SYNCHRONY: CENTRAL TENETS AND EMPIRICAL APPLICATION
Authors: Pauly Theresa , Gerstorf Denis , Wahl Hans-Werner , Lüscher Janina , Scholz Urte , Hoppmann Christiane
Published: December 2023

Most current models of social dynamics and health focus on individuals; our developmental-contextual model of couple synchrony (CoSynch) proposes a uniquely dyadic approach and deliberately moves to a N + 1 perspective. CoSynch emphasizes the importance of between-person synchrony for shaping development and health, which refers to the way in which physiological states and health behaviors fluctuate in sync between romantic partners. Synchrony is proposed to follow a u-shaped curve across adulthood, with younger and older couples showing greater synchrony than middle-aged couples, and with greater diversification of synchrony in very old age. We assume that synchrony is shaped by the closeness and shared contexts of couples, and is correlated with individual and dyad characteristics (e.g., attachment). Prior research has linked synchrony to perspective taking and effective collaboration. Thus, synchrony is assumed to be important for supportive interactions in couples managing chronic disease. As an empirical illustration, we apply the CoSynch model to analyze 992 daily life assessments from 11 Swiss couples in which one partner had Type II diabetes. Specifically, we used a smartphone and smartwatch system (DyMand) that captured daily social contexts and heart rate synchrony. Couples showed small to moderate interconnections in their heart rate fluctuations, which tended to be stronger when engaged in conversation with the partner. We will discuss the utility of using wearables to better understand health-relevant social developmental dynamics. Insights from collecting such data could be used to inform future interventions using technology to promote healthy aging and adaptive disease management.
DEVELOPMENTAL ORIGINS OF EXCEPTIONAL HEALTH AND SURVIVAL: A FOUR-GENERATION COHORT STUDY
Authors: Keys Matthew , Larsen Pernille , Pedersen Dorthe , Kulminski Alexander , Feitosa Mary , Wojczynski Mary , Christensen Kaare
Published: December 2023

Little is known about the early life health trajectories associated with longevity, due to the length of follow-up required for such studies. In the Long Life Family Study (LLFS) we have identified 659 Danish long-lived sibships and their descendants across three generations and followed them through national civil and health registries. We have previously shown lower adult mortality and morbidity in both offspring and grandchildren generations. Here we compared perinatal, infant, and maternal health outcomes of third-generation grandchildren (n = 5637) and also fourth-generation great-grandchildren (14,908) born into these long-lived families between 1973-2018, to matched controls from the general population. Hazard ratios (HRs) and odds ratios (ORs) were estimated by Cox proportional hazards and conditional logistic regression models. A general pattern of reduced risk was observed in the grandchildren across a range of perinatal and infant health outcomes, most notably in infant mortality (HR = 0.53, 95% CI [0.36, 0.77]), preterm birth (OR = 0.82, [0.72, 0.93]), and low birth weight (OR = 0.83, [0.76, 0.90]). These associations were robust to further adjustment for parental education levels. Negligible infant survival advantage was observed in the great-grandchildren (HR = 0.90, [0.70, 1.17]). However, there were signals of benefit across some other perinatal outcomes, although much fewer and weaker in magnitude than in the grandchildren. Our findings suggest that phenotypic longevity may have developmental origins as early as the perinatal period, and that this effect persists over at least three generations.
ASSOCIATIONS OF NIGHT AND DAY SLEEP WITH COGNITIVE PERFORMANCE IN SHIFT WORKERS: PRELIMINARY RESULTS
Authors: Kim Jinyoung , Yook Soonhyun , Nam Stephanie , Kim Hosung , Alavi Mohammad Hesam , Oliver Joanna , Lim Diane
Published: December 2023

Emerging evidence suggests that night shift workers are at higher risk of severe cognitive impairment, mainly because of the repeated disruption of the sleep–wake schedule and the resulting poor sleep (e.g., less deep sleep or shorter sleep time). However, questions remain about how daytime and nighttime sleep characteristics correlate with cognitive performance in shift workers. The purpose of this study is to examine the association of objective sleep quality, measured on workdays and days off, with cognitive performance, determined by the psychomotor vigilance task (PVT), in shift workers compared to day workers. We included eight night shift and ten day shift workers from an ongoing pilot study in this analysis. Participants undergo multiple home sleep studies with electroencephalograms on their workdays or days off. Sleep quality measures include total sleep time (TST), percentage of deep sleep stage in TST, and wake time after sleep onset (WASO). Night shift workers showed longer TST and shorter WASO during their nighttime sleep on days off compared to day shift workers. In night shift workers, longer deep sleep on days off was significantly correlated with faster mean reaction time to a visual stimulus (better cognitive performance) on the PVT (r = -.944, p = .016), after controlling for age. However, longer deep sleep during their daytime sleep was associated with slower reaction time (r = .756, p = .049). Further studies are necessary to elucidate differential impacts of daytime and nighttime sleep on the risk of future cognitive impairment in night shift workers.
NURSING HOME STAFF UNDERSTANDING AND CONFIDENCE IMPLEMENTING MONTESSORI APPROACHES AFTER TRAINING
Authors: Hilgeman Michelle , Kennedy Katherine , Haigh Sylvia , Mochel Amy , Bishop Teddy , Curyto Kimberly , Mills Whitney
Published: December 2023

Staff understanding and confidence delivering non-pharmacological interventions are critical for improving outcomes related to behavioral distress in dementia. We conducted a mixed methods evaluation with frontline staff (nursing, recreation therapists, etc.) at 8 VA Community Living Centers enrolled in a stepped-wedge cluster randomized trial of Montessori-based approaches. Training and data collection were conducted remotely and surveys were shortened to reduce participant burden. Normalization Process Theory (NPT, May et al., 2022) guided questions and analysis. Staff completed N=21 qualitative interviews, N=307 surveys (1-month pre-training and during baseline), and N=906 post-training evaluations. Results revealed 83%-87% passed post-training knowledge exams. NPT surveys reflected Montessori was not a normal part of staff work currently (M=5.58 and 6.35 on a 10-point scale); though they believed it would become a normal part of their work in the future (M=7.11 and 7.68). After training, Montessori was rated as more familiar (M=5.15 to M=6.55, t=-3.12, p=.002), and significantly more staff reported that their role included Montessori delivery/oversight X2=13.26(2), p=.001. Content analysis was used to examine qualitative transcripts for the NPT domain Coherence (e.g., comprehension, self-efficacy, internalization). Three themes emerged: 1) ability to describe Montessori principles, 2) familiarity with Montessori approach, and 3) willingness to try it. All participants were able to describe Montessori, though some reported conditional self-efficacy/confidence. Representative quotes reflect challenges and successes in understanding and early application of the intervention in VA CLC environments. Considerations for pragmatic trial designs amid fluctuating COVID precautions are also discussed (e.g., nursing shortages, implementation and evaluation discrepancies, and site-level variability).
USING THE LTSS STATE SCORECARD TO MEASURE PROGRESS ON THE 2022 NATIONAL STRATEGY TO SUPPORT FAMILY CAREGIVERS
Authors: Tell Eileen , Nadash Pamela
Published: December 2023

Through the Recognize, Assist, Include, Support, & Engage (RAISE) Family Caregivers Act of 2018, the RAISE Family Caregiver Advisory Council was created. Since 2019, the Council has directed in-depth information-gathering and research efforts to develop recommendations and an implementation plan for addressing our critical family caregiving crisis. The Council recently released the 2022 National Strategy to Support Family Caregivers, which highlights nearly 350 actions the federal government will take to support family caregivers in the coming year and more than 150 actions that can be adopted at other levels of government and across the private sector to build a system to support family caregivers. Integrating measures of improvement with regard to family caregiver support, across the domains identified in the National Strategy into the LTSS State Scorecard will provide a tool by which progress toward the RAISE goals can be measured. Currently, the Scorecard focuses on indicators specific to Supporting Working Family Caregivers. While these are critical, our research team has identified at least 10 additional indicators that could be included and that would address other caregiver support domains such as adequacy of direct care workforce, integration of family caregivers into care plans, direct pay to family caregivers, and more. In this session we will identify the indicators, explain how they relate to RAISE goals and discuss methods for including them in the Scorecard.
NO PENSION, NO HAPPINESS?—FINANCIAL SUPPORT EXPECTATION IN THE OLDEST-OLD AGE AND DEPRESSIVE SYMPTOMS
Authors: Han Chengming , Zhou Nan
Published: December 2023

Objective

This paper aims to explore the effect of financial support expectation on depressive symptoms among the oldest-elderly. Method. Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS) 2018. The analytical sample included 10641 respondents who were older than 45. Financial support expectations refer to whom they would reply on when they cannot work, which includes four categories: children, themselves (savings or commercial life insurance), pensions, and others. Linear regression models were employed after controlling for pension, health insurance and urban-rural household registration (hukou).

Results

More than half of the sample reported that they would rely on their children when they became too old to work. Those who reported that they would rely on themselves (b=-1.72, p=0.000) or pensions (b=-1.23, p=0.000) reported lower levels of depressive symptoms compared to those who would rely on their children. When pension and health insurance were controlled for, only those who would rely on themselves presented lower level of depressive symptoms. Pension and health insurance (except rural health insurance) mediated the association between the financial support expectation and depressive symptoms. However, the hukou status inhibited the mediating effect of pension and health insurance.

Conclusion

Financial uncertainty is a potential threat in the oldest-old age. Reducing the urban-rural inequality in pension and health insurance would help reduce the negative effects of financial uncertainty.
ASSOCIATION BETWEEN MULTIPLE FRAILTY INDICES AND CVD MORTALITY
Authors: Seligman Benjamin , Qazi Saadia , Rane Manas , Preis Sarah , Orkaby Ariela , Gaziano J Michael , Driver Jane
Published: December 2023

Introduction Frailty, a syndrome of physiologic vulnerability, increases cardiovascular disease (CVD) risk. Which frailty tool is ideal for risk stratification remains unclear. We calculated three frailty scores from the Million Veteran Program (MVP) and examined their association with mortality and CVD in older Veterans. Methods Participants were from MVP - a large, contemporary Veteran cohort study - and aged ≥50 years at baseline (2011-2018). The frailty scores used were: MVP-FI (36-item questionnaire deficit accumulation frailty index), VA-FI (31-item EHR index), and modified Study of Osteoporotic Fractures (mSOF; a physical frailty score). MVP-FI and VA-FI scores of ≤0.10 were robust, 0.11-0.20 pre-frail, and ≥0.21 frail; mSOF scores of 0 were robust, 1 pre-frail and ≥2 frail. Primary outcomes were all-cause and CVD mortality. Secondary outcomes were incident stroke, myocardial infarction (MI), and heart failure (HF). Cox regression was used to evaluate the association of frailty with outcomes. Results Among 190,688 participants, mean age was 69 ±9, 94% were male. By MVP-FI, 29% were robust, 42% pre-frail, and 29% frail. Hazard ratios (HR, 95% CI) for all-cause mortality were 1.66 (1.61-1.72) and 3.05 (2.95-3.16) for pre-frailty and frailty, respectively. For CVD mortality, HRs were 1.76 (1.65-1.88) and 3.65 (3.43-3.90) for pre-frailty and frailty. Hazards of stroke, MI, and HF also increased with greater frailty. VA-FI and mSOF yielded concordant results. Conclusion Irrespective of measure, frailty is associated with increased all-cause mortality and CVD event risk. Clinicians and researchers may consider the most convenient tool for available data to incorporate frailty into practice.
SATISFACTION WITH WALK ON! FROM PROGRAM CLIENTS AND LEADERS
Authors: Ajja Rahma , Kemp Elizabeth Chmelo , Hughes Jaime , Van Laethem Lauren , Welsh Kimberly , Guerrier Tami , Hirsch Mark , Nicklas Barb
Published: December 2023

This presentation demonstrates the high degree of satisfaction with Walk On! from qualitative survey data from both clients and program leaders. As part of the curriculum, each attendee completes a survey asking about satisfaction around location, day/time, length of program, and changes in walking abilities. The survey also includes an opportunity for open-ended responses and suggestions for improvement. Overall, surveys showed a very high degree of satisfaction with the program with 80-100% of clients indicating they are “Very Much” satisfied with the program components. All open-ended responses were positive and examples include: “Very pleased with the instruction and environment”; “Encouraged me to walk at home and neighborhood”; “This program gave me energy to walk better and has changed my life”; “Enjoyed the fellowship with others”; and “I now walk with more confidence”. Leaders also complete a satisfaction survey upon completion of their Leader Training program and after leading a Walk On! program. A majority of the leaders “Strongly Agreed” or “Agreed “that: The length of the training was appropriate (83%); Course materials were explained well (100%); Course materials were easy to use (100%); I feel prepared to lead Walk On! (67%). Leader statements include: “I loved everything about this program. It was not just a walking program to me. I had social, cognitive and physical growth” and “This program afforded me the opportunity to have a real collaborative, immersive experience with elders.” Together, these positive findings support the need to scale and spread WalkOn! into additional community settings.
REPORTING MERIT-BASED INCENTIVE PAYMENT SYSTEM LIKE DATA IN A UNIQUE AGE-FRIENDLY HEALTH CARE SETTING
Authors: Waters Leland , Slattum Patricia
Published: December 2023

The Richmond Health and Wellness Program (RHWP) offers screening, education, care coordination, and resources as an enhancement to primary care for older adults in five low-income apartment buildings and in a community center. Participants may receive primary care through multiple healthcare systems in the region that do not have a common electronic medical record (EMR). To track age-friendly workflows to the Health Resources Services Administration (HRSA) in the domains of advance care planning, falls prevention, and high-risk medication use, case note documentation in a REDCap database is used to generate Merit-based Incentive Payment System (MIPS)-like data. We report on advance care plans developed, fall risk screenings and risk reduction interventions implemented, high-risk medications screened, and referrals to primary care for high-risk medication deprescribing, including risk reduction with opioid use. When reporting MIPS data to HRSA, we include a disclaimer for RHWP data defining the numerator and denominator used for the MIPS-like measure calculation. For example, when reporting advance care plan completion, we include “RHWP is a care coordination site and care is not provided at the site. The population includes adults aged 55+ or people (of any age) with disabilities in low-income congregate living facilities and all adults participating in RHWP at the Virginia Commonwealth University Health Hub.” The numerator indicates the number of clients with advanced care plans created, and the denominator indicates the total number of clients seen during the reporting period. This presentation will provide strategies to meet reporting requirements when EMR records are not available.
LINKING MERIT-BASED INCENTIVE PAYMENT SYSTEM (MIPS) MEASURES TO AGE-FRIENDLY HEALTH SYSTEMS
Authors: Murphy Sara , Severance Jennifer , Ross Sarah , Taylor Kate , Knebl Janice
Published: December 2023

IHI’s Age-Friendly Health Systems initiative provides a framework for older adult primary care focused on the 4Ms: Mentation, Mobility, Medications, and What Matters which addresses the need for an integrated system of care. Additionally, the Centers for Medicare & Medicaid Services have implemented merit-based incentivized payment system (MIPS) measures to promote provider practices that improve healthcare quality. MIPS measures and age-friendly care practices may be improved through training, which may lead to better patient outcomes. To integrate the 4Ms to improve care and patient safety, the Center for Older Adults at the University of North Texas Health Science Center standardize workflows and increase the number of annual wellness visits (AWV). A standardized template in the electronic medical record was created, questions in the patient registration software were added to identify eligible patients, and three different types of AWVs were standardized. Training courses were developed and completed by providers. The percentage of patients who receive an AWV is measured on an annual basis. Learnings have been integrated into training courses. Between July 2020 to June 2021, 297 healthcare professionals completed online training modules, with post-survey ratings showing helpful content with learning objectives being met. Provider support through training and incorporating MIPS measures and the Age-Friendly 4Ms framework into the AWV can support consistent outcome measurement and improve quality care for older adults.
SEXUAL MOTIVES, MARITAL QUALITY, AND DEPRESSIVE SYMPTOMS OF MID-LIFE SAME- AND DIFFERENT-SEX COUPLES
Authors: Chai Hye Won , Joo Susanna , Lee Jihye , Umberson Debra
Published: December 2023

Self-determined sexual motives, or self-endorsed reasons for having sex, is a significant determinant of psychological health with notable gendered patterns. However, previous studies mostly focused on young adult different-sex couples and fell short of exploring the mechanisms through which self-determined sexual motives are associated with psychological health. Using dyadic data from the Health and Relationships Project (HARP) on 124 gay, 171 lesbian, and 124 straight midlife married couples, this study examined the mediating role of marital quality in the association between self-determined sexual motives and depressive symptoms. Actor-partner interdependence mediation model (APIMeM) was used for analyses. Results showed significant mediating effects of individual’s own marital quality for all couple types (i.e., gay, lesbian, straight couples), such that individuals with higher levels of self-determined sexual motives reported better marital quality, which in turn was associated with their lower levels of depressive symptoms. For partner effects, same patterns emerged for lesbian and gay couples wherein individuals’ own marital quality mediated the association between their spouse’s sexual motives and their own depressive symptoms. However, there were gendered patterns within straight couples. For women, their own marital quality mediated the association between their partner’s sexual motives and their own depressive symptoms. For men, their spouse’s marital quality mediated the association between their partner’s sexual motives and their own depressive symptoms. These findings suggest marital quality as a useful intervention point to enhance the psychological health of midlife couples in same-sex and different-sex marriages and also highlight the salience of gendered dynamics within straight couples.
EFFECTS OF MENOPAUSE AND MARITAL TRANSITIONS ON SUBJECTIVE SEXUAL SELF-EFFICACY AMONG MIDDLE-AGED AND OLDER ADULTS
Authors: Ferguson Melissa , Liu Yin
Published: December 2023

Circumstances in aging including menopause, physical decline, widowhood, divorce and remarriage may influence sexual experiences and well-being in later life. While marital transition can affect both men and women in middle and older life, menopausal transition is especially salient for aging women. This study aims to examine how subjective sexual self-efficacy changes over time and whether marital transitions and menopausal transitions moderate the trajectories. Participants completed two waves of the Midlife in the United States (MIDUS) surveys (N = 1002), ranging from 40 to 84 years of age at baseline (M = 57.44; SD = 10.17) with over half being female (54%, n = 538). Factor analysis confirmed a one-factor model with a five-item subjective sexual self-efficacy construct. Over 10 years, 12% of participants experienced marital transitions, and 29% of women reporting menstrual status experienced menopause transition. Growth curve analysis was used the examine the research questions.
DYADIC EFFECTS OF PERSONALITY AND SEXUAL BEHAVIOR IN OLDER ADULTHOOD
Authors: Chopik William
Published: December 2023

Personality traits are associated with important life, work, and relational outcomes across the lifespan. Although personality has been implicated in models of relationship functioning, there has been relatively little research matching individual and partner personality characteristics to the frequency, quality, and variety of sexual experiences, particularly in older adulthood. The current study examined individual and spousal effects of the Big Five personality traits on sexual outcomes among 953 older opposite-sex couples followed from 2010/2011 to 2015/2016 as part of the National Social Life, Heath, and Aging Project (NSHAP; Mage = 70.60, SD = 7.92; 74.2% White, 12.2% Hispanic, 11.1% Black, and 2.5% other). Individual and spousal conscientiousness was associated with more frequent dyadic and solitary sexual activity and being part of a physically pleasurable and emotionally satisfying relationship. Those with higher levels of neuroticism and those married to spouses high in neuroticism expressed a lower preference for physical/sexual touch and cuddling, were less likely to report having a physically pleasurable and emotionally satisfying relationship, and were more likely to avoid having sex because of physical problems (and report more pain during sex). Longitudinal analyses suggested that most of these associations wavered in strength over time. The findings are discussed in the context of how relationship processes might mediate the link between personality characteristics and sexual outcomes or whether sexual outcomes promote relationship-enhancing characteristics depending on people’s personalities.
COMPARING THE ASSOCIATION BETWEEN DIABETES AND MORTALITY IN TWO INDEPENDENT BIRTH COHORT OF OLDER ADULTS IN MEXICO
Authors: Downer Brian , Castro Jose Cabrero
Published: December 2023

The prevalence of diabetes among middle-aged and older adults in Mexico has nearly doubled since the year 2000. This increase is primarily due to healthcare reforms that promoted diabetes screening. Insulin use and other treatments have also increased during the same period. Early diagnosis and treatment can reduce diabetes mortality risk. However, it is unclear if the increased diagnosis and treatment of diabetes in Mexico have reduced the mortality risk associated with diabetes in older adults. We used the Mexican Health and Aging Study to compare the association between diabetes and 5-year mortality in two independent cohorts of adults aged 60-69 in 2001 (1932-1941) and 2012 (1943-1952). The final sample included 3,694 participants in 2001 and 4,769 in 2012. Demographic variables included age, gender, education, living in an urban community, and having health insurance coverage. Self-reported health conditions included diabetes, hypertension, stroke, and respiratory disease. We used cox-proportional hazard regression models that included an interaction term for diabetes by cohort and adjusted for demographic and self-reported health characteristics. Overall, diabetes was associated with 2.56 times higher mortality (95% CI=2.18-3.00). The 2012 cohort did not have significantly different mortality risk compared to the 2001 cohort (HR=0.91, 95% CI=0.77-1.07). The association between diabetes and mortality for participants in the 2001 cohort (HR=2.52, 95% CI=1.95-3.26) was not significantly different from the 2012 cohort (HR=2.58, 95% CI=2.09-3.17). Our results indicate that diabetes continues to be a major risk factor for mortality in Mexico despite the increase in screening and treatment.
MULTIDIMENSIONAL EVALUATION OF BIOLOGICAL AGE USING NMR METABOLOMICS AND ANTHROPOMETRY IN 35,541 ADULTS IN MEXICO
Authors: Bello-Chavolla Omar Yaxmehen , Fermin-Martinez Carlos , Fernández-Chirino Luisa , Ramírez-García Daniel , Antonio-Villa Neftali , Núñez-Luna Alejandra , Sánchez-Castro Paulina , Basile-Alvarez Martin Roberto
Published: December 2023

Aging occurs across different domains at the individual level, encompassing distinct physiological systems which can be captured using biological age (BA) metrics. Second generation BA metrics are aimed at proxying BA using 10-year mortality risk and include PhenoAge and AnthropoAge. Here, we explored the complementary application of AnthropoAge and an NMR-Metabolomics derived BA measure to explore aging in body composition and metabolic domains in a subsample of 35,541 participants of the Mexico City Prospective Study. Using LASSO Cox regression, we identified 17 metabolites associated with all-cause mortality, in men and 75 in women. We then fitted age-adjusted Gompertz regression models and identified 7 unique metabolites for men and 15 for women. We transformed the results from these regressions to define MetaboAge. Both AnthropoAge (AUC 0.784, 95%CI 0.778-0.790) and MetaboAge (AUC 0.808, 95%CI 0.802-0.814) showed superior performance for prediction of all-cause mortality compared to chronological age (AUC 0.779, 95%CI 0.773-0.786). By regressing AnthropoAge and MetaboAge onto chronological age we obtained acceleration metrics (≥0 defined accelerated aging). By combining acceleration metrics from anthropometry and NMR-metabolomics we identified distinct trajectories of all-cause mortality. Notably, cases with acceleration only in AnthropoAge (HR 1.43, 95%CI 1.33-1.54) and those with acceleration only in MetaboAge (HR 1.86, 95%CI 1.73-2.01) had higher risk of all-cause mortality compared to non-accelerated cases but lower compared to cases with acceleration in both metrics (HR 2.28, 95%CI 2.12-2.45). Multidimensional evaluation of BA may prove useful to capture heterogeneity of aging in diverse populations by capturing aging at distinct physiological domains.
REFERRAL OF ASIANS TO SKILLED NURSING FACILITIES: FINDINGS FROM THE 2019 NATIONAL MEDICARE DATA
Authors: Nguyen Hoang , Li Chih-Ying , Tzeng Huey-Ming , Tahashilder Md Ibrahim , Kuo Yong-Fang
Published: December 2023

A recent study of skilled nursing facilities (SNF) found Asian/Pacific Islanders are the most physically dependent and have the greatest cognitive impairment among all residents. Whether or not this is due to differential referral pattern to skilled nursing facilities is not known. We conducted a retrospective analysis of the 2019 national Medicare data to compare differences in referral to SNF among Asian, Black, Hispanic, and White adults ages 66 years and older following hospitalization for fracture (n=148,493), heart failure (n=377,398), joint replacement (n=509,347), pneumonia (n=258,614), urinary tract infection (n=195,816), or sepsis (n=518.619). Asians had the second lowest rates of SNF referral for all medical conditions examined, except for joint replacement. Hispanic had the lowest rates. For joint replacement, Asians had the highest rate of referral. The SNF referral rates among Asians compared to whites were 70.1% and 71.6% for fracture, 16.4% and 22.4% for heart failure, 16.8% and 21.2% for pneumonia, 30.1% and 34.6% for urinary tract infection (UTI), 29.3% and 32.5% for sepsis, and 32.1% and 23.4% for joint replacement. Asians had significantly lower odds of SNF referrals after hospitalization for fracture (OR=0.71; 95% CI: 0.65-0.77), heart failure (OR=0.51; 95% CI: 0.48-0.54), pneumonia (OR=0.46; 95% CI: 0.42-0.49), UTI (OR=0.59; 95% CI: 0.54-0.63), and sepsis (OR=0.55; 95% CI: 0.53-0.57), but significantly higher odds after joint replacement (OR=1.19; 95% CI: 1.12-1.26) compared to non-Hispanic White adults. The reason for the lower referral rates is unclear but could be from a lack of culturally appropriate facilities. More culturally appropriate facilities are needed.
EMOTIONAL ADJUSTMENTS OF CUSTODIAL GRANDPARENTS LIVING WITH COVID-19: A NATIONAL PERSPECTIVE
Authors: Whitley Deborah , Kelley Susan , Fruhauf Christine , Smith Andrea , Hayslip Bert
Published: December 2023

Living with COVID-19 demands has created emotional challenges for grandparents raising grandchildren. The aim of this study was to explore the emotional adjustment of custodial grandparents’ caregiving under COVID demands (e.g., masking, hand washing, social distancing) (N=145; age range 30-79 years, Mage = 61.4 years, SD = 8.5). A national sample of grandparents were surveyed using a multi-scale index of psychological distress, reliance on intrapersonal resources during the pandemic, as well as sociodemographics. An initial hierarchical regression analysis of caregivers’ emotional adjustment was conducted, wherein (1) sociodemographic variables were first entered as a set followed by 2) a 17-item measure of COVID demands (alpha = .73), 3) two indices of grandparent intrapersonal resources [resilience and empowerment/social support and religious coping], and 4) two indices of psychosocial stress [parental distress, health, social/emotional and loneliness/parental distress, parent-child dysfunction, difficult child and parenting challenges]. The overall model was statistically significant (F 11, 123 = 22.98, p < .01), accounting for 64% of the variance in grandparent adjustment difficulties. While sociodemographics and COVID demands failed to predict emotional distress, both categories of grandparent intrapersonal resources (p < .01), and both categories of psychosocial stress (p < .01) did so. Subsequent correlational findings indicated that intrapersonal resources (social support and religious coping) mediated the relationship between COVID demands and emotional adjustment. These findings suggest that while grandparent caregivers experienced significant emotional distress during the pandemic, reliance upon the support of others as well as their own intrapersonal resources may be instrumental in managing such distress.