bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposal of Measurement Occasions for Unbiased Evaluation of Psychotherapy
Authors: Geissner Edgar , Ivert Petra Maria , Schmitt Manfred
Published: March 2021

Studies complementing the assessment of symptoms right before (t1), right after therapy (t2), and at follow-up (t3) with an assessment of symptoms preceding the waiting period without intervention (t0) have revealed substantial t0–t1 changes. We discuss this phenomenon based on our own data and address the following questions: does it make sense to compare symptoms at the beginning of therapy (t1) with symptoms at the end of therapy (t2) or at follow-up (t3)? Or does it make more sense to use t0 instead of t1? We argue for the latter alternative based on the following reasons. (1) Symptom descriptions at t0 are realistic. (2) Expecting therapy success mitigates symptom descriptions at t1. (3) Security signals emitted from the therapy context also mitigate symptoms, especially anxiety, at t1. (4) Regression toward the mean reduces the validity of single occasion assessments. Controlling for regression requires two occasions of measurement with a short time interval at t0 (t01 and t02). It follows from this reasoning that therapy success should be evaluated using the t02–t2 and t02–t3 intervals. Single case evaluations require reliable critical differences. This will be illustrated using a concrete example. The validity of treatment evaluation can be increased via the elimination of non-pathological symptom scores. A simplified calculation of cut-off scores can facilitate applied treatment evaluation. Unspecific t0–t1 changes do not challenge therapy effects according to t1–t2 changes. Rather, they are part of the whole therapy process.
Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a CDH1 Gene Germline Mutation
Authors: Pinto Cláudia , Cunha Ana Luísa , Rodrigues Ângelo , Dias Renata , Brandão Catarina , Dinis-Ribeiro Mário
Published: March 2021

Carriers of the mutated CDH1 gene have an increased risk of developing early-onset signet-ring cell (diffuse) gastric cancer. We present a case of a young patient with a confirmed mutation of the CDH1 gene, who was diagnosed with a gastric marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) from surveillance endoscopy. He underwent Helicobacter pylori eradication treatment and was subsequently submitted to a total prophylactic gastrectomy. The surgical specimen only revealed foci of signet-ring cell carcinoma (SRCC) in situ without lymphoma signs. We highlight here the occurrence of other pathology in high-risk patients as well as its possible influence on the decision to perform gastrectomy.
Recurrence and Recovery of COVID-19 in an Older Adult Patient with Multiple Comorbidities: A Case Report
Authors: Leung Shannon , Hossain Nasiffa
Published: March 2021

The coronavirus disease 2019 (COVID-19) pandemic has become a worldwide public health crisis since December 2019. Reports of COVID-19 recurrences are uncommon but raise the question of whether patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will develop lasting immunity against or whether there are multiple viral strains that need to be considered. Although severe disease typically occurs in older individuals with comorbidities, this case report describes a patient in this demographic group who presented with COVID-19 recurrence and remained relatively asymptomatic throughout both disease courses. This case highlights how SARS-CoV-2 appears to affect some patients unpredictably, indicating that more research is needed to further understand its viral pathophysiology and disease outcomes.
Digestive Oncology in the COVID-19 Pandemic Era
Authors: Brito Mariana , Laranjo Ana , Sabino Júlia , Oliveira Carla , Mocanu Irina , Fonseca Jorge
Published: March 2021

Introduction: Since the rise of the COVID-19 pandemic there has been widespread concern regarding the possible delay in the diagnosis/treatment of cancer patients. We aimed to assess the impact of the COVID-19 pandemic on the diagnosis, treatment, and outcome of patients with digestive cancer. Methods: This was a retrospective study including patients with an inaugural digestive cancer diagnosis discussed for the first time at our center during the weekly digestive oncology reunion (DOR) meeting. The study group was enlisted from March to August 2020, and a control group was sourced from the equivalent period of 2018. Patients with a previous digestive cancer diagnosis/discussion in the DOR were excluded. The following data were collected: demographics, referral origin, tumor staging, first DOR discussion timing, treatment, and outcome. Results: A total of 235 patients were included: 107 in the study group (65.4% male, mean age 71.59 years); 128 in the control group (54.7% male, mean age 68.16 years). The mean number of clinical discussions per week was higher in 2018 (13.65 vs. 10.67, p = 0.040), without a difference in the mean number of patients discussed for the first time (inaugural diagnosis) between groups (p = 0.670). In the 2020 study group, more patients were referred to DOR from the emergency room (ER), fewer from the outpatient clinic/hospital wards (p < 0.001), and more were referred after urgent surgery (p = 0.022). There was no difference in the mean waiting time from diagnosis to first DOR discussion (p = 0.087). Tumor staging in colorectal, gastric, and esophageal cancer was not significantly different between the groups (p = 0897, p = 0.168, and p = 0.717). More patients in the study group presented with stage IV pancreatic cancer (p = 0.043). There was no difference in the time span from DOR until the beginning of neoadjuvant chemotherapy (p = 0.680) or elective surgery (p = 0.198), or from surgery until adjuvant chemotherapy (p = 0.396). Also, there was no difference in 30-day mortality from the first DOR date between the groups (p = 0.742). Conclusion: During the COVID-19 era there was a reduced number of clinical discussions in the DOR, but the number of debated patients with an inaugural digestive cancer diagnosis was similar. In the study group more patients were referred to DOR from the ER, and were referred after urgent surgery, suggesting a delayed demand for clinical attention. Study group patients were not significantly affected by the pandemic regarding timely DOR discussion, beginning of treatment, or 30-day mortality, reflecting the maintenance of the quality of care for digestive cancer patients.
Are All Purposes Worth Having? Integrating Content and Strength in Purpose Research
Authors: Burrow Anthony L. , Agans Jennifer P. , Jeon Hee Jin , Creim Michael
Published: March 2021

A prevailing belief is that a sense of purpose in life is worth having, based on evidence that it predicts greater psychological functioning, social relationships, physical health, and longevity. Yet, whether the benefits of having a sense of purpose persist across all contents – or the actual substance of one’s aspirations – lingers as a critical blind spot within this literature. Here, we contend that an ecological systems perspective is needed to contextualize how purpose content either enables or extinguishes the benefits of feeling purposeful. We nominate congruence (the fit between a purpose and ecological conditions) and feasibility (the ease with which a purpose can be pursued) as measurable features of purpose content that fuse people and contexts and potentiate whether a sense of purpose proves favorable. Greater congruence and feasibility should orchestrate support for purpose-related goals, actions, and justifications, thus amplifying the likelihood of positive outcomes. Practical strategies for integrating the congruence and feasibility of individuals’ aspirations within the study of purpose are discussed.
Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects
Authors: Curtis David
Published: March 2021

It is plausible that variants in the ACE2 and TMPRSS2 genes might contribute to variation in COVID-19 severity and that these could explain why some people become very unwell whereas most do not. Exome sequence data was obtained for 49,953 UK Biobank subjects, of whom 82 had tested positive for SARS-CoV-2 and could be presumed to have severe disease. A weighted burden analysis was carried out using SCOREASSOC to determine whether there were differences between these cases and the other sequenced subjects in the overall burden of rare, damaging variants in ACE2 or TMPRSS2. There were no statistically significant differences in weighted burden scores between cases and controls for either gene. There were no individual DNA sequence variants with a markedly different frequency between cases and controls. Whether there are small effects on severity, or whether there might be rare variants with major effect sizes, would require studies in much larger samples. Genetic variants affecting the structure and function of the ACE2 and TMPRSS2 proteins are not the main explanation for why some people develop severe symptoms in response to infection with SARS-CoV-2. This research was conducted using the UK Biobank Resource.
Pancreatic Acinar Cell Carcinoma with Germline BRCA2 Mutation and Severe Pancreatic Panniculitis: A Case Report
Authors: Dreikhausen Lena , Schulte Nadine , Belle Sebastian , Weidner Philip , Moersdorf Johannes , Reissfelder Christoph , Ebert Matthias P. , Zhan Tianzuo
Published: March 2021

Pancreatic acinar cell carcinoma (ACC) is a rare malignant disease that displays distinct differences to pancreatic ductal adenocarcinoma. Here, we report the case of a patient with ACC and underlying breast cancer susceptibility gene 2 (BRCA2) germline mutation that developed severe pancreatic panniculitis (PP) during the course of the disease. The patient received a multimodal therapy including surgery, systemic chemotherapy, and targeted therapy with the PARP inhibitor olaparib, resulting in an overall survival of 47 months. Findings from this case are compared to the current knowledge on management of ACC and paraneoplastic PP.
Polypoidal Choroidal Vasculopathy in Caucasians: Morphological Findings from Multimodal Retinal Imaging
Authors: Simão Jorge M. , Farinha Cláudia V. , Marques João P. , Nunes Sandrina , Pires Isabel M. , Cachulo Maria L. , Figueira João P. , Murta Joaquim N. , Silva Rufino M.
Published: March 2021

Purpose: The aim of the study was to characterize the morphological features of polypoidal choroidal vasculopathy (PCV) in a large Caucasian population. Methods: We conducteda multicenter, cross-sectional study of treatment-naïve patients with PCV. Baseline fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA) were assessed by trained medical graders. Typical PCV features were explored, and retinal thickness (RT) and choroidal thickness (CT) measurements were performed. Results: Seventy-nine eyes of 73 patients (mean age, 72.6 ± 11.9 years) were included. ICGA identified macular polyps in 89.9% of cases. SD-OCT revealed mostly subretinal fluid (93.6%) and a retinal pigment epithelium (RPE) detachment in 91.4%, with sharp protrusion in 67.0% of cases. Polyp-like structures were seen in 74.3% of cases, mostly adherent to an elevated RPE (69.6%). Type 1 neovascularization (NV) was identified in 74.7% of patients, while 16.5% had a mixed NV. The mean macular CT was 220.9 ± 83.2 μm (range, 67.9–403.6). Diffuse and focal pachychoroid were observed in 26.6 and 30.4% of patients, respectively. Soft drusen were reported in 62.0% of cases, but retinal hemorrhage occurred in only 19.0% of cases. Conclusion: The morphological features of PCV in Caucasians are similar to those reported in Asians. Pachychoroid signs were found in nearly half of our cohort. However, the mean age at presentation, high prevalence of soft drusen, and low prevalence of large subretinal hemorrhages make PCV closer to age-related macular degeneration in this ethnic group.
Endoscopic Features of Superficial Esophageal Squamous Cell Carcinoma in Patients with Very Low Risk Factors (Female, Nondrinking, and Nonsmoking): A Case-Control Study
Authors: Inoue Takahiro , Ishihara Ryu , Matsuura Noriko , Kitamura Masanori , Shichijo Satoki , Maekawa Akira , Kanesaka Takashi , Yamamoto Sachiko , Takeuchi Yoji , Higashino Koji , Uedo Noriya , Michida Tomoki
Published: March 2021

Background: Although esophageal squamous cell carcinoma (ESCC) is more likely to develop in patients with any risk factor (male, drinking, or smoking), it is sometimes detected in patients with very low risk factors (female, nondrinking, and nonsmoking). We examined the endoscopic features of superficial ESCC in patients with very low risk factors. Methods: In this single-center case-control study, 666 patients with 666 superficial ESCC lesions were divided into 2 groups: those with very low risk factors (very low-risk group, n = 34) and those with any risk factors (any-risk group, n = 632). After case-control selection at a 1:5 ratio, the very low-risk group comprised 34 patients and the any-risk group comprised 170 patients. We compared the baseline characteristics, endoscopic findings, and treatment results (including pathological diagnosis) between the 2 groups. Results: There were no statistically significant differences between the 2 groups in age, tumor size, tumor location, tumor morphology, or treatment results (including tumor depth and lymphovascular invasion). A longitudinal lesion with an attachment of white keratinized epithelium was more likely to be detected in the very low-risk group than the any-risk group (61.8 vs. 17.6%, respectively; p < 0.001). Conclusions: ESCC in patients with very low risk factors is rare but can be encountered in daily practice. A longitudinal lesion with an attachment of white keratinized epithelium is its main characteristic, which is slightly different from that of patients with any risk factors.
Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART
Authors: Upadhya Bharathi , Pajewski Nicholas M. , Rocco Michael V. , Hundley W. Gregory , Aurigemma Gerard , Hamilton Craig A. , Bates Jeffrey T. , He Jiang , Chen Jing , Chonchol Michel , Glasser Steve P. , Hung Adriana M. , Pisoni Roberto , Punzi Henry , Supiano Mark A. , Toto Robert , Taylor Addison , Kitzman Dalane W. ,   for the SPRINT Research Group
Published: March 2021

In a subgroup of 337 participants (mean age 64±9 years; 45% women) from the SPRINT (Systolic Blood Pressure Intervention Trial), where participants were randomly assigned to intensive treatment (target systolic blood pressure <120 mm Hg) versus standard treatment (<140 mm Hg), we examined the effect of intensive blood pressure lowering on indexes of aortic stiffness. Carotid-femoral pulse wave velocity, a validated global measure of aortic stiffness, was measured by echo-guided Doppler at baseline and 18-month follow-up visit. Aortic elastance, distensibility, and compliance were measured by cardiac magnetic resonance imaging. During follow-up, the intensive treatment produced a mean between-group reduction in systolic blood pressure of 12.7 mm Hg (95% CI, 11.1–14.3 mm Hg). During follow-up, intensive treatment significantly attenuated the increase in carotid-femoral pulse wave velocity compared with standard treatment (adjusted follow-up least square mean=9.0 m/s [95% CI, 8.7–9.3] versus 10.0 m/s [9.6–10.3];
P
<0.001), an effect that persisted even after adjusting for mean arterial pressure. Intensive treatment also decreased the aortic elastance index (least square mean, 1.38 mm Hg/mL per m
2
[95% CI, 1.34–1.41] versus 1.48 mm Hg/mL per m
2
[95% CI, 1.44–1.51],
P
=0.002) compared with standard treatment. No significant between-group differences were observed for aortic distensibility and compliance. We conclude that intensive treatment significantly attenuated increases in carotid-femoral pulse wave velocity and aortic elastance index. Attenuation of increases in aortic stiffness may be one of the mechanisms contributing to the benefit of intensive blood pressure treatment observed in SPRINT.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01206062.
MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury
Authors: Wang Junni , Nie Wanyun , Xie Xishao , Bai Mengqiu , Ma Yanhong , Jin Lini , Xiao Liang , Shi Peng , Yang Yi , Jose Pedro A. , Armando Ines , Chen Jianghua , Lin Weiqiang , Han Fei
Published: March 2021

Inflammation and maladaptive repair play a crucial role in the development of chronic kidney disease and hypertension after acute kidney injury. To study the mechanisms involved in acute kidney injury-to-chronic kidney disease transition, we established a chronic renal fibrosis mouse model that was triggered by an initial ischemia/reperfusion–induced acute kidney injury (acute-chronic model). Downregulation of microRNA-874-3p during renal fibrosis was identified by a genome-wide RNA-sequencing and was further confirmed in cell-based assays, mouse models, and human samples. Overexpression of microRNA-874-3p in the kidneys markedly alleviated renal fibrosis, accompanied with decreased infiltrated macrophages and expression of α-smooth muscle actin, type I collagen, fibronectin, CCL (C-C motif chemokine ligand) 2, and ADAM (A Disintegrin and Metalloprotease) 19.
ADAM19
is a target gene of microRNA-874-3p as shown by luciferase reporter assays and was upregulated in the acute-chronic model. Overexpression of ADAM19 directly induced the expression of fibrotic genes, CCL2, and macrophage infiltration in vivo. Depletion of macrophages using clodronate liposomes ameliorated the fibrogenic effects of ADAM19. Overexpression of ADAM19 also induced accumulation of the Notch1 intracellular domain, an upstream regulator of CCL2 expression, whereas Notch1 pathway antagonist N-(N-[3,5-difluorophenacetyl]-L-alanyl)-S-phenylglycine t-butyl ester reduced CCL2 level in ADAM19-overexpressed cells. Collectively, microRNA-874-3p/ADAM19 mediates renal fibrosis after acute kidney injury by increasing macrophage infiltration via the Notch1/CCL2 pathway.
At the Intersection of Eco-Crises, Eco-Anxiety, and Political Turbulence: A Primer on Twenty-First Century Ecofascism
Authors: Thomas Cassidy , Gosink Elhom
Published: March 2021

This article explores the concept of ecofascism during the twenty-first century. In the midst of worsening ecological crises, a revival of ecofascist rhetoric and action has been observed. Despite this resurfacing, there is a lack of theorizing around the topic. This discussion will explore how the ecofascist label has been applied in different contexts historically, and the ways it may manifest in the twenty-first century. We hope that this stimulates conversation and awareness around ecofascism and serves as a guide to identify various ecofascist rhetorical tools, policies, and proposals.
Globalization and Its Contradictions: China’s Developing Path
Authors: Lixin Hao
Published: March 2021

Globalization is a process of contradictions and value conflicts. Developing countries are faced with various challenges in this process. Economic globalization is essentially global-wide expansion of the capitalist economy. Inherent contradictions of economic globalization can be divided into original and derivative contradictions. The inherent contradiction of the capitalist economy determines its two different aspects, its corresponding effects upon the world history, as well as conflicts between economic, political, and cultural values. Being exposed to this process, China needs to make wise choices.
Biopolitics in the Time of Pandemic: Populism and Neoliberalism in the Light of COVID-19
Authors: Soborski Rafal
Published: March 2021

Populism is at the center of many debates about socio-political aspects of the COVID-19 pandemic. However, pondering questions such as, “Is coronavirus bad for populism?” or “How do populist leaders respond to it?” is unlikely to bring significant insights into the distribution and operation of power in the context of COVID-19, or more generally. The populist label is used by elites to describe any politics that they dismiss, whether right- or left-wing, rendering populism an empty and incoherent concept. This point is supported by developments associated with COVID-19 as attitudes of “populist” regimes towards the pandemic varied and some of them followed the same strategies as those pursued by “non-populist” governments. This article reveals the limited explanatory utility of the concept of populism and proposes shifting the focus of attention towards neoliberalism as a key factor shaping individual countries’ responses to the ongoing biopolitical challenge.
The generic nomenclature of the emeralds, Trochilini (Apodiformes: Trochilidae): two replacement generic names required
Authors: BRUCE MURRAY D. , STILES F. GARY
Published: March 2021

Many genus-level changes to the classification of Trochilini were enacted in Stiles et al. (2017b). We have since found that two further genera therein emended each require replacement names. The first of these requiring a replacement name is Uranomitra Reichenbach, 1854 [March], which is herewith interpreted as an additional synonym of Saucerottia Bonaparte, 1850, along with its junior synonym Cyanomyia Bonaparte, 1854a [May]. We show that both must have the same type species, as originally designated, Trochilus quadricolor Vieillot, 1822 = Ornismya cyanocephala Lesson, 1829. The second case in which a replacement name is required is Leucolia Mulsant & E. Verreaux, 1866, herewith interpreted as an additional synonym of Leucippus Bonaparte, 1850, with the same type species, Trochilus fallax Bourcier, 1843. We herein propose replacement names for both Uranomitra and Leucolia.
The Use of the Conway–Maxwell–Poisson in the Seasonal Forecasting of Tropical Cyclones
Authors: Mitchell Timothy D. , Camp Joanne
Published: March 2021

The Conway–Maxwell–Poisson distribution improves the precision with which seasonal counts of tropical cyclones may be modeled. Conventionally the Poisson is used, which assumes that the formation and transit of tropical cyclones is the result of a Poisson process, such that their frequency distribution has equal mean and variance (“equi-dispersion”). However, earlier studies of observed records have sometimes found overdispersion, where the variance exceeds the mean, indicating that tropical cyclones are clustered in particular years. The evidence presented here demonstrates that at least some of this overdispersion arises from observational inhomogeneities. Once this is removed, and particularly near the coasts, there is evidence for equi-dispersion or underdispersion. To more accurately model numbers of tropical cyclones, we investigate the use of the Conway–Maxwell–Poisson as an alternative to the Poisson that represents any dispersion characteristic. An example is given for East China where using it improves the skill of a prototype seasonal forecast of tropical cyclone landfall.
Otolaryngology Consult Protocols in the Setting of COVID-19: The University of Pittsburgh Approach
Authors: Dharmarajan Harish , Belsky Michael A. , Anderson Jennifer L. , Sridharan Shaum
Published: March 2021

Objective:

To analyze trends in otolaryngology consultations and provide algorithms to guide management during the COVID-19 pandemic.

Methods:

A retrospective cohort study at a single institution tertiary care hospital. A total of 95 otolaryngology consultations were performed from March 1, 2020 to April 26, 2020 (COVID-era) and 363 were performed from September 1, 2019 to February 29, 2020 (pre-COVID-era) at the UPMC Oakland campus. Data collected included patient demographics, COVID-19 status, reason for consult, location of consult, type of consult, procedures performed, need for surgical intervention, length of hospital stay and recommended follow up.

Results:

Patient populations in the pre-COVID-era and COVID-era were similar in terms of their distribution of demographics and chief complaints. Craniofacial trauma was the most common reason for consultation in both periods, followed by vocal fold and airway-related consults. We saw a 21.5% decrease in the rate of consults seen per month during the COVID-era compared to the 6 months prior. Review of trends in the consult workflow allowed for development of several algorithms to safely approach otolaryngology consults during the COVID-19 pandemic.

Conclusions:

Otolaryngology consultations provide valuable services to inpatients and patients in the emergency department ranging from evaluation of routine symptoms to critical airways. Systematic otolaryngology consult service modifications are required in order to reduce risk of exposure to healthcare providers while providing comprehensive patient care.
Kids and Diabetes in Schools (KiDS) intervention in India: Participants’ perspectives
Authors: Rawal Tina , Bhaumik Soumyadeep , Shrivastav Radhika , Nazar Gaurang P , Tandon Nikhil , Arora Monika
Published: March 2021

Objectives:

The purpose of this study was to assess the experience and satisfaction of teachers and parents of children with and without diabetes, with the Kids and Diabetes in School (KiDS) intervention. Project KiDS aimed to foster a safe and supportive school environment to encourage the management of type 1 diabetes and prevention of type 2 diabetes.

Design:

This qualitative evaluation involved semi-structured, face-to-face, in-depth interviews with a purposive sample of 35 respondents, including teachers and parents of children with and without diabetes attending the selected schools at 1 and 3 months post-intervention implementation. In total, n = 5 schools (3 government and 2 private) were selected out of 15 schools in which the KiDS project was implemented.

Methods:

In total, 65 interviews were conducted in two rounds. The sample comprised teachers ( n = 20 in round 1; n = 18 in round 2), parents of children with diabetes ( n = 3 in both the rounds) and parents of children without diabetes ( n = 15 in round 1; n = 6 in round 2) attending five schools. Data were analysed using the thematic framework method.

Results:

Teachers reported gaining new knowledge as a result of the KiDS intervention. They felt more confident in assisting children with diabetes. Suggestions to strengthen the KiDS resource pack were the inclusion of case studies and audio-visual aids. Parents of children with diabetes reported that the project reinforced information and improved diabetes management skills. Their suggestions for strengthening KiDS materials included the provision of additional technical information. The parents of children without diabetes reported that the resource pack aided a better understanding of diabetes and clarified myths and misconceptions. Suggestions for strengthening the pack included the regular reinforcement of information on diabetes among children.

Conclusion:

Findings support the upscaling of KiDS work elsewhere in India through the engagement of multiple stakeholders to promote the management and prevention of diabetes in school.
Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis
Authors: Kumar Ashok , Kumar Poninder , Mishra Sanjay Kumar , Goyal Sumit
Published: March 2021

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. A few studies suggested that HIV contributes to the ocular manifestations of syphilis and HIV co-infection in approximately 30%. Acute syphilitic posterior placoid chorioretinopathy is a rare ocular manifestation in immune-competent patients characterised by the development of a deposit in the outer retina. We describe an unusual such presentation with hypopyon.
Incorporating the Biological Bases of Behavior Throughout Introduction to Psychology: A Review and Application of 7½ Lessons About the Brain
Authors: Williamson Manda J.
Published: March 2021

Introduction:

Research suggests benefits for incorporating popular press books into courses to encourage critical thinking and student-instructor interactions about concepts.

Objective:

This article offers a summary and critique of 7 ½ Lessons about the Brain by Lisa Feldman-Barrett along with pedagogical strategies for integrating the book within Introduction to Psychology courses.

Teaching Implications:

This popular press book affords an opportunity to incorporate a biopsychology thematic approach to Introduction to Psychology. Several pedagogical strategies using active learning and collaboration are provided.

Conclusion:

Choosing to include a popular press book in class to supplement student learning may benefit critical thinking about many concepts presented within Introduction to Psychology.
Policy implications of climate change denial: Content analysis of Russian national and regional news media
Authors: Yagodin Dmitry
Published: March 2021

This article investigates the policy implications of national and regional climate change denial in Russia. While in general Russia has lagged behind in its climate mitigation policy, its key fossil-fuel regions are actively responding to external initiatives and pressures. As the country generally lacks substantial climate policy initiatives, the focus of this study is on the symbolic policy reactions operationalized as the media coverage of climate change at the national and regional levels in Russia during 2017–2018. Following the theoretical perspective of disproportionate policy response, the analysis elaborates on one of the suggested causes of policy over and underreactions, namely, the level of public demand for policy action. The findings indicate potential for disproportionate policy response research to conceive of public demand in broader terms, distinguishing between local, national and international domains.
Mitral valve replacement through mini sternotomy after long ECMO course: Case report
Authors: Abdalghafoor Tamer , Sarhan Hatem , Kindawi Ali
Published: March 2021

Introduction:

Mitral regurgitation (MR) is defined as an abnormal reversal of blood flow from the left ventricle to the left atrium (LA). It is caused by disruption in any part of the mitral valve apparatus. Surgical intervention remains the mainstay of management for severe cases.

Case summary:

We are reporting a case of pneumonia with severe sepsis, that had a complicated hospital course. The patient developed multi-organ failure. Echocardiography on admission showed severe mitral regurgitation. He required early mechanical ventilation and then Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) over 29 days. He might be the first case of Coronavirus Disease 2019 (COVID-19) in our hospital. Mitral valve replacement was done after stabilization of the patient and weaning from the ECMO.

Discussion:

Our report demonstrates that the use of a long term VV-ECMO as a bridge for stabilization, facilitates management of the critically ill respiratory failure patient with severe MR and patient outcomes. Still the long-term results and the optimal timing of intervention need more research to define.

Conclusion:

Our report demonstrates that the use of a long term VV ECMO facilitates management of patients with respiratory failure associated with severe MR. Future studies focusing on stabilizing such patients, might help to define the optimal timing for intervention in these patients and the long-term outcome.
Cannabis-induced oceanic boundlessness
Authors: Earleywine Mitch , Ueno Luna F , Mian Maha N , Altman Brianna R
Published: March 2021

Background:

Despite tetrahydrocannabinol (THC)’s reputation for creating dramatic effects at high doses, empirical work rarely addresses cannabis’s impact on subjective responses common to the tryptamine psychedelics. We focused on these effects because they have preceded and covaried with the therapeutic impact of psilocybin in previous work.

Aims:

The current study examined if self-reported responses to cannabis products might parallel those found in clinical trials of psilocybin administration. We also investigated if measures of demographics and cannabis use might correlate with these responses.

Methods:

Participants reported the subjective effect of their highest THC experience using 27 items that assess oceanic boundlessness, a correlate of mystical experiences. They also answered infrequency items and questions on demographics and cannabis consumption.

Results:

In an effort to address concerns about replication, we divided respondents who passed infrequency items into two random samples. Self-reported “breakthrough” experiences were significantly greater than zero but significantly lower than those reported in randomized clinical trials of psilocybin (17–19% vs. 59%). Total scores covaried with perceived dosages of THC, but only in one sample. Heavier users of cannabis reported lower scores.

Conclusions:

Self-report data suggest that high doses of cannabis can create subjective effects comparable to those identified in trials of psilocybin that precede relief from cancer-related distress, treatment-resistant depression, alcohol problems, and cigarette dependence. Given the disparate mechanisms of action, comparing THC-induced to psilocybin-induced effects might improve our understanding of the mechanisms underlying subjective experiences. This work might also support the development of a cannabis-assisted psychotherapy comparable to psilocybin-assisted psychotherapy.
Effects of hydrocortisone and yohimbine on selective attention to emotional cues
Authors: Metz Sophie , Chae Woo R , Deuter Christian E , Otte Christian , Wingenfeld Katja
Published: March 2021

Introduction:

Facial expressions contain important affective information, and selective attention to facial expression provides an advantage in the face of loss, stress and danger. In addition, the sympathetic nervous system and hypothalamus-pituitary-adrenal axis mediate the organism’s response to loss and danger. Here, we aimed at investigating the influence of sympathetic nervous system and hypothalamus-pituitary-adrenal axis activation on selective attention to affective facial stimuli.

Methods and materials:

One hundred-and-four healthy men between 18–35 years old (mean (standard deviation) age: 24.1 (3.5) years) participated in the study. We used a randomised, double-blind, placebo-controlled design. Participants received either: (a) yohimbine, (b) hydrocortisone, (c) yohimbine and hydrocortisone or (d) placebo only and participated in a dot-probe task with sad, happy and neutral faces. We collected salivary samples to measure cortisol and alpha amylase activity in addition to measurements of blood pressure and heart rate. Salivary cortisol served as correlate of hypothalamus-pituitary-adrenal axis activation and salivary alpha amylase activity, blood pressure and heart rate as correlates of sympathetic nervous system activation. Measurements were carried out before and after drug administration.

Results:

We did not find a main effect or interaction effect of hydrocortisone or yohimbine administration on selective attention to happy faces. However, we found an interaction of yohimbine and hydrocortisone on selective attention to sad faces. Post-hoc t-test revealed an attentional bias away from sad stimuli and towards neutral faces in the hydrocortisone-only group.

Discussion:

Only hydrocortisone administration led to an attentional bias away from sad faces. Future studies should investigate these effects in major depression disorder, as this disorder is characterised by glucocorticoid resistance and increased processing of sad stimuli.
A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation
Authors: Dittmer Keren E. , Pemberton Sarah
Published: March 2021

The skeletal system is a common site for neoplasia in dogs and cats, and primary bone tumors may develop from any of the mesenchymal tissues present in bone. Imaging and histopathology are routinely used in the diagnosis of bone tumors, and the 2 techniques are highly complementary. While imaging may be highly suggestive of a specific diagnosis and treatment may be instituted based on this, definitive diagnosis requires histopathology of either incisional or excisional biopsies or an amputation specimen. However, there are a number of diagnostic dilemmas when the pathologist interprets bone biopsy samples, such as distinguishing reactive bone and tumor bone, fracture callus and tumor bone, different benign fibro-osseous lesions, and different types of bone sarcoma. This review outlines the characteristic radiographic and histologic changes associated with these diagnostic problems to aid in resolving them. When a holistic approach is taken to evaluation of the signalment, history, and clinical, radiologic, and microscopic features, a diagnosis may be possible. The pathologist is greatly assisted in the interpretation of bone samples by having access to imaging and should routinely request either the images or the imaging reports if they are not received from submitting veterinarians.
Hybrid Machine Learning Algorithm for Identifying Feature Levels Associated with Safety Critical Events
Authors: Mousa Saleh , Mousa Ragab , Fadaly Amany , Jamil Khalid
Published: March 2021

According to the National Highway Traffic Safety Administration (NHTSA), about seven million traffic accidents claimed more than 36,560 human lives in the U.S. in 2018 . These statistics have prompted researchers to investigate the driver characteristics associated with safety-critical events (SCE). This paper presents a hybrid CatBoost algorithm for identifying the feature levels associated with SCE. The model accounts for numerous difficulties and drawbacks reported in the literature. The model was trained and validated using the entire set of the Second Strategic Highway Research Program Naturalistic Driving Study (SHRP2-NDS) events (crash/near-crash and normal/baseline). Results indicate that secondary tasks (interacting with object in-vehicle, reaching for objects in the vehicle, pet interaction, cellphone/tablet use, and writing/texting), intersection influence (parking lots/driveway/entrance/exit, uncontrolled intersections, traffic signals, interchanges, and stop signs), income (under $29,000 and $100,000–$149,000), age (16–19 and 20–24), traffic density (level of service C, D, and E/F), high sensation-seeking tendency (scoring 18–35 on a scale of 35), low driving knowledge (scoring 0–8.9 on a 19-point scoring system questionnaire), and gender = female are the feature levels having an association with SCE with a probability varying between 51% and 87%. Results also revealed that passenger interactions, eating/drinking, driving away from intersections or interchanges, being age 70—79, or driving in traffic density = A are more related to safe driving. Consideration of these results can contribute to reducing roadway crashes and improve traffic safety.
Predictive Artificial Neural Network Laboratory Fatigue Endurance Limit Model for Asphalt Concrete Pavements Based on the Volumetric Properties and Loading Conditions
Authors: Isied Mayzan M. , Souliman Mena I. , Zeiada Waleed A. , Bastola Nitish R.
Published: March 2021

Asphalt concrete healing is one of the important concepts related to flexible pavement structures. Fatigue endurance limit (FEL) is defined as the strain limit under which no damage will be accumulated in the pavement and is directly related to asphalt healing. Pavement section designed to handle a strain value equivalent to the endurance limit (EL) strain will be considered as a perpetual pavement. All four-point bending beam fatigue testing results from the NCHRP 944-A project were extracted and utilized in the development of artificial neural network (ANN) EL strain predictive model based on mixture volumetric properties and loading conditions. ANN model architecture, as well as the prediction process of the EL strain utilizing the generated model, were presented and explained. Furthermore, a stand-alone equation that predicts the EL strain value was extracted from the developed ANN model utilizing the eclectic approach. Moreover, the EL strain value was predicted utilizing the new equation and compared with the EL strain value predicted by other prediction models available in literature. A total of 705 beam fatigue lab test data points were utilized in model training and evaluation at ratios of 70%, 15%, and 15% for training, testing, and validation, respectively. The developed model is capable of predicting the EL strain value as a function of binder grade, temperature, air void content, asphalt content, SR, failure cycles number, and rest period. The reliability of the developed stand-alone equation and the ANN model was presented by reasonable coefficient of determination (R2) value and significance value (F).
Histopathological and Radiographic Features of Osteolysis After Fixation of Osteochondral Fragments Using Poly-L-Lactic Acid Pins for Osteochondral Lesions of the Talus
Authors: Ikuta Yasunari , Nakasa Tomoyuki , Sumii Junichi , Nekomoto Akinori , Adachi Nobuo
Published: March 2021

Background:

Fixation of osteochondral fragments is a potential option for treating an osteochondral lesion of the talus (OLT) involving large lesions in the remaining articular cartilage surface. Bioabsorbable devices, especially those made of poly-L-lactic acid (PLLA), can be used for the fixation of an OLT. Postoperative osteolysis surrounding the PLLA pins is occasionally observed; however, the significance of osteolysis remains unknown.

Purpose:

To elucidate the association between osteolysis surrounding the PLLA pins, histopathological findings in subchondral bone, and preoperative Hounsfield unit (HU) values at the pin fixation site.

Study Design:

Case Series; Level of evidence, 4.

Methods:

This retrospective analysis included 20 patients with OLT (11 men and 9 women; mean age, 20.9 years; 1 bilateral case). Tissue from the osteochondral fragment was collected intraoperatively using a bone biopsy needle for histological evaluation. The fragment was fixed through the biopsy hole using a PLLA pin. Osteolysis surrounding the PLLA pin was assessed at 1 year postoperatively using magnetic resonance imaging (MRI). Histopathological scores were assigned based on trabecular bone loss, empty lacunae, inflammatory granulation tissue, cartilage-like tissue, and the presence of osteoclasts. The HU values around the pin insertion site, detected on the postoperative MRI scans, were measured using the region of interest based on the preoperative coronal and sagittal computed tomography (CT) images.

Results:

Osteolysis was observed postoperatively in 9 ankles (42.9%). Histopathological evaluation revealed that the osteolysis group had a significantly higher pathological score than the nonosteolysis group (10.2 vs 6.3; P < .001). Lower HU values were identified in the osteolysis group on preoperative coronal and sagittal CT images ( P < .05). The histopathological score negatively correlated with preoperative HU values (Pearson r = −0.46; P = .037).

Conclusion:

Intraoperative biopsy of the OLT allowed for histopathological evaluation of the same site as that of the PLLA pin fixation. Our findings suggest that preoperative subchondral trabecular deterioration is associated with the incidence of postoperative osteolysis surrounding the PLLA pin. Additionally, low preoperative HU values in subchondral bone under OLT may serve as a predictor of osteolysis surrounding the PLLA pin.
Spontaneous urinary bladder perforation: An unusual presentation of well-differentiated papillary peritoneum mesothelioma
Authors: Serao Armando , Ambrosini Francesca , Cavallone Barbara , Borra Tiziana , Di Stasio Andrea
Published: March 2021

Introduction:

Well-differentiated papillary mesothelioma (WDPM) is a very rare neoplasm. Most of WDPM are asymptomatic and are often incidentally detected during surgery. This report describes a case of WDPM of the peritoneum unexpectedly diagnosed in a male with a spontaneous intraperitoneal bladder rupture.

Case presentation:

A 65-year-old male presented to our Emergency Department in November 2019 with a two-day history of anuria, abdominal pain, distention, and sepsis. The CT scan reported a large amount of extra and intraperitoneal free fluid. The CT cystogram showed bladder perforations on the dome and on the left lateral wall which was repaired through exploratory laparotomy. Intraoperatively, we encountered extensive suppurative peritonitis with large fibrino-purulent exudation. The purulent perivesical peritoneum was dissected and sent for histopathological examination which unexpectedly resulted in WDPM of the peritoneum.

Conclusion:

Although we can’t affirm with certainty, this case would seem to suggest that WDPM had played a role in patient’s clinical presentation. However, further research is necessary to draw stronger conclusion.
Machine learning–based reduced-order modeling of hydrodynamic forces using pressure mode decomposition
Authors: Ahmed Hassan F , Farooq Hamayun , Akhtar Imran , Bangash Zafar
Published: March 2021

In this article, we introduce a machine learning–based reduced-order modeling (ML-ROM) framework through the integration of proper orthogonal decomposition (POD) and deep neural networks (DNNs), in addition to long short-term memory (LSTM) networks. The DNN is utilized to upscale POD temporal coefficients and their respective spatial modes to account for the dynamics represented by the truncated modes. In the second part of the algorithm, temporal evolution of the POD coefficients is obtained by recursively predicting their future states using an LSTM network. The proposed model (ML-ROM) is tested for flow past a circular cylinder characterized by the Navier–Stokes equations. We perform pressure mode decomposition analysis on the flow data using both POD and ML-ROM to predict hydrodynamic forces and demonstrate the accuracy of the proposed strategy for modeling lift and drag coefficients.
How Collective-Action Failure Shapes Group Heterogeneity and Engagement in Conventional and Radical Action Over Time
Authors: Lizzio-Wilson Morgana , Thomas Emma F. , Louis Winnifred R. , Wilcockson Brittany , Amiot Catherine E. , Moghaddam Fathali M. , McGarty Craig
Published: March 2021

Extensive research has identified factors influencing collective-action participation. However, less is known about how collective-action outcomes (i.e., success and failure) shape engagement in social movements over time. Using data collected before and after the 2017 marriage-equality debate in Australia, we conducted a latent profile analysis that indicated that success unified supporters of change ( n = 420), whereas failure created subgroups among opponents ( n = 419), reflecting four divergent responses: disengagement (resigned acceptors), moderate disengagement and continued investment (moderates), and renewed commitment to the cause using similar strategies (stay-the-course opponents) or new strategies (innovators). Resigned acceptors were least inclined to act following failure, whereas innovators were generally more likely to engage in conventional action and justify using radical action relative to the other profiles. These divergent reactions were predicted by differing baseline levels of social identification, group efficacy, and anger. Collective-action outcomes dynamically shape participation in social movements; this is an important direction for future research.
Was Wegner rejecting mental causality?
Authors: Marvan Tomáš
Published: March 2021

Daniel Wegner’s theory of apparent mental causation is often misread. His aim was not to question the causal effectiveness of conscious mental states, such as intentions. Rather, he attempted to show that our subjective sense of agency is not a completely reliable indicator of the causality of action and needs to be replaced by more objective means of inquiry.