bluuebunny/crossref_metadata_2025 huggingface dataset:
A case of electric injury with exposed neck vessels and scapula treated with flaps
Authors: Bhatia Vijay , Thakur Archana , Narola Sruja , Singh Manisha , Kaushik Rahul , Kalra Deepanjali
Published: June 2023

In modern times, the use of electricity has increased many times and so has the incidence of high-voltage electrical injuries. The incidence of high-voltage electrical injuries is much higher in developing countries when compared to developed countries, lack of proper transmission systems being the cause. Electric burn injuries lead to debilitating morbidity to the affected patients and are often deadly. In such cases with exposed vessels in the neck, major flaps such as the deltopectoral flap or forehead flap or free flaps increase the hospital stay or two-staged procedures and hence increase the morbidity of such patients. Here, we present a case of a young male patient who sustained an electric injury to his foot, neck, and shoulder, which was managed with the platysma flap and parascapular flap with no donor site morbidity.
A case report: Secondary cancers due to oncological treatment modalities
Authors: Gulmez Ahmet
Published: June 2023

Background:

Breast cancer (BC) is one of the most common cancers worldwide. In recent years, numerous non-chemotherapy agents have been developed for BC treatment, including targeted agents, new hormonal therapies, and immunotherapies. However, despite the widespread use of these agents, chemotherapies are still an important cornerstone in BC treatment. Similarly, serious de-escalation studies in radiotherapy use have been conducted in recent years. These two treatment modalities, which we frequently use in the treatment of BC due to their effectiveness, may also have serious side effects.

Case Presentation:

In this article, I will present a case of multiple myeloma (MM) and myxofibrosarcoma (MFS) that occurred many years later in a patient who completed adjuvant chemotherapy and radiotherapy for BC. MM has developed due to previous chemotherapy and MFS has developed due to previous radiotherapy.

Conclusion:

We usually treat our cancer patients with chemotherapy or radiotherapy to prolong their lives. In addition to the benefits we provide, may negatively affect the lifetime and quality of life by causing the development of metachronous secondary cancers in some patients. In this case report, I will present the “ironic” side of oncology science and treatment.
A dose escalated fiducial marker-based image guided radical radiotherapy in locally advanced prostate cancers: A single institute experience from India
Authors: Gupta Pramod K. , Rastogi Neeraj , Das Koilpillai Joseph Maria , Kumar Shaleen
Published: June 2023

Purpose:

Image guided radiotherapy (IGRT) is one of the most commonly used treatment in LAPC. Dose escalation >74 Gy has shown to improve the biochemical control and freedom from failure rate in LAPC.We started treating LAPC patients with dose escalated IGRT in our institute since 2008. We did a retrospective analysis to see the biochemical relapse-free survival, cancer-specific survival, and bladder and rectal toxicity.

Methods:

A total of 50 consecutive prostate cancer patients were treated with dose escalated IGRT between January 2008 to Dec 2013. Out of these, 37 patients of LAPC were analyzed and their medical records were retrieved. All were biopsy proven adenocarcinoma of prostate with D’Amico high risk category (PSA >20 ng/mL or Gleason score (GS) >7 or T2c-T4). Three gold fiducial markers were placed in the prostate. Patients were immobilized in supine position with either ankle or knee rest. Partial bladder filling and rectum emptying protocol was followed. Clinical target volume (CTV) segmentation was done according to EORTC recommendation. Population based PTV expansion from CTV of 10 mm (cranio-caudal), 10 mm (medio-lateral), 10 mm (anterior) and 5 mm (posterior) was given. In patients with radiologically enlarged pelvic lymph node, whole pelvis intensity modulated radiation therapy (IMRT) to a dose of 50.4 Gy/28# followed by prostatic boost 26Gy/13# by IMRT using image guidance. Rest of the patients received prostate only RT to a dose of 76Gy/38# by IGRT. Daily On board KV images were taken and 2D-2D fiducial marker matching was done and shifts were applied on machine before treatment. Biochemical relapse was defined as per Phoenix definition (nadir + 2 ng/mL). Radiation Therapy Oncology Group (RTOG) toxicity grading system was used to document acute and late toxicity.

Results:

Median age of patients was 66 years. Median pre-treatment PSA was 22 ng/mL. Thirty patients (81%) had T3/T4 lesions and nodal metastasis was seen in 11 (30%). Median GS was 8. Median radiotherapy dose was 76 Gy. Imaging before radiation delivery was done in 19(51%) patients and 100% in 14 (38%) patients. With a median follow up of 6.5 years, 5-year biochemical relapse-free survival (bRFS) and cancer-specific survival (CSS) was 66% and 79% respectively. Mean bRFS and CSS were 71 months and 83 months however Median bRFS and CSS were not reached. Distant metastasis was seen in 8 (22%). RTOG grade III bladder and rectal toxicity was seen in 2 (6%) and 2 (6%) patients respectively.

Conclusion:

Dose escalated IGRT with fiducial marker positional verification for LAPC is doable in Indian setup provided more emphasis given on daily on-board imaging with rigorous bladder filling and rectal emptying protocol. Long term follow up is needed to assess the effect on distant disease-free survival and CSS.
The effect of the ATM inhibitor AZD0156 on the radiosensitivity of human breast cancer and lung fibroblast cells
Authors: Yilmaz Ugur , Kamer Deniz , Asik Aycan , Kara Hale G. , Gündüz Cumhur , Kamer Serra
Published: June 2023

Aims:

To evaluate the effect of the combination of irradiation and AZD0156 on apoptosis, cell cycle progression, and clonogenic survival in human breast cancer and fibroblast cells.

Methods and Material:

Estrogen receptor-positive breast cancer cell line MCF-7 and healthy lung fibroblast cell line WI-38 were obtained. Following employing proliferation analysis, cytotoxicity analysis was done to calculate the IC50 values of AZD0156 in MCF-7 and WI-38 cell lines. Following the application of AZD0156 and irradiation, flow cytometry analysis was performed for evaluating cell cycle distribution and the extent of apoptosis. Plating efficiency and surviving fraction were calculated for the clonogenic assay.

Statistical Analysis Used:

SPSS Statistics for Windows, Version 17.0. (SPSS Inc. Chicago) and GraphPad Prism Version 6.0 for Windows (GraphPad Software, San Diego, California USA) softwares were used to analyze data.

Results:

AZD0156 and irradiation dose of 2–10 Gy had no effect on apoptosis on MCF-7 cells. The combination treatment of AZD0156 and 2 Gy, 4 Gy, 6 Gy, 8 Gy, and 10 Gy irradiation induced G0/G1 phase arrest by 1.79, 1.79, 1.50, 1.25, and 1.52-fold compared to the control group, respectively on MCF-7 cell lines. Combination treatment of AZD0156 and each different irradiation dose affected clonogenic survival owing to increased radiosensitivity (p: 0.02). AZD0156 and irradiation dose of 2 Gy, 4 Gy, 6 Gy, 8 Gy, and 10 Gy decreased the cell viability rate of WI-38 cells by 1.05, 1.18, 1.22, 1.04, and 1.05-fold compared to the control group, respectively. No efficacy was detected on cell cycle analysis, and clonogenic survival was not significantly decreased in WI-38 cells.

Conclusion:

The combination use of irradiation and AZD0156 has improved efficacy of tumor cell-specific cell cycle arrest and decreasing clonogenic survival.
An experience with simultaneous integrated boost-volumetric-modulated arc therapy in the definitive treatment of head and neck cancer: An Indian data
Authors: Shivananjappa Rashmi , Mandal Sanjeet Kumar , Vishwanathan Bhaskar , Geeta S N
Published: June 2023

Background:

There are very few prospective studies comparing simultaneous integrated boost versus sequential boost in the setting of definitive treatment modality of head and neck squamous cell cancer (HNSCC), especially in the Indian scenario.

Materials and Methods:

We prospectively randomized 50 patients with biopsy-proven squamous cell carcinoma of the oropharynx, hypopharynx, and larynx malignancies, stage T1–3, enlarged node measuring ≤3 cm that are planned for definitive radiotherapy with chemotherapy into either hypo-fractionated simultaneous integrated (Hypo-SIB VMAT) boost arm or conventional (Conv-VMAT) boost arm.

Results:

Most of the patients were men and aged less than 50 years. Patients with nodal involvement were 76% in Hypo-SIB VMAT and 80% in Conv-VMAT arm. The overall stage group distribution of II, III, and IVA were 16%, 44%, 40%, and 12%, 56%, and 32%, respectively, in both arms. All patients completed the intended treatment in both arms. Overall survival at the end of 2 years was 84% in Hypo-SIB VMAT arm and 80% in the Conv-VMAT arm (P = 0.25); disease-free survival (DFS) was 88% and 72%, respectively (P = 0.12); and locoregional recurrence-free survival (LRFS) was 92% and 84%, respectively (P = 0.38). All the acute and chronic toxicities in both the arms were comparable with no significant difference in any of the toxicities. The average overall treatment time (OTT) in Hypo-SIB VMAT arm is 39.4 days and in Conv-VMAT arm is 50.2 days (P = 0.00001) which is statistically significant.

Conclusions:

Accelerated Hypo-SIB VMAT has similar response and toxicities as compared to Conv-VMAT in the setting of definitive concurrent chemoradiation of HNSCC patients with the advantage of less OTT, faster treatment delivery, and patient compliance.
Expression of TP53 in oral squamous cell carcinoma and its correlation with adverse histopathological features
Authors: Giri Ranjana , Hota Subhransu Kumar , Sahu Subrat Kumar , Senapati Urmila
Published: June 2023

Background:

This study aimed to evaluate the expression of TP53 in oral squamous cell carcinoma (OSCC) and to correlate its expressions with adverse histopathological features like depth of invasion (DOI), lymphovascular invasion (LVI), perineural invasion (PNI), extranodal extension (ENE), and margin status which significantly affect the prognosis.

Methodology:

This cross-sectional study included 48 patients of OSCC who underwent surgical resection. All the histopathological adverse features such as DOI, LVI, PNI, ENE, margin status were noted. Immunohistochemical expression of TP53 was noted and a correlation of TP53 with histopathological adverse features was done. Statistical analysis was performed using SPSS software.

Results:

TP53 immunopositivity was seen in 45.83% (22/48) of cases. TP53 has a statistically significant correlation with margin status (P = 0.002). Similarly, TP53 expression is more in cases with LVI (100% cases) though the value is not statistically significant. TP53 expressions are more in positive margin cases and less if the margin is >5 mm. Similarly, TP53 expression is more in cases with LVI (100% cases) though the value is not statistically significant.

Conclusion:

Few parameters that did not show the correlation of TP53 with adverse histopathological features could be attributed to a small sample size. Further studies with a large number of cases and using other ancillary molecular diagnostic techniques would throw further light on the exact alteration of TP53 in our population and their association with histopathological prognostic features.
Frequency and pattern of chromosomal abnormalities in acute myeloid leukemia from Western India: A retrospective study
Authors: Vundinti Babu Rao , Korgaonkar Seema , Dhangar Somprakash , Jijina Farah , Shanmukhaiah Chandrakala
Published: June 2023

Context:

Chromosomal abnormalities play an important role in diagnosis and prognosis of hematological diseases.

Aims:

The aim of the present study was to study the pattern and frequency of chromosomal aberrations in acute myeloid leukemia (AML) subgroups from western India.

Settings and Design:

A retrospective study was conducted through evaluating laboratory proforma which were filled during 2005 to 2014 for diagnosis and treatment of AML subjects.

Methods and Material:

We have studied chromosomal aberrations in 282 subjects with AML from western India. AML patients were sub-grouped according to FAB classification. Cytogenetic study using conventional cytogenetics (GTG-banding) and Fluorescence in situ hybridization (FISH) was carried out using FISH probes (AML1/ETO, PML/RARA, CBFB).

Statistical analysis:

Student’s t test for continuous variables and Pearson’s Chi-squared test for categorical variables were used to identify the relationship between variables.

Results:

Cytomorphological study revealed AML- M3 as most frequent (32.3%) group followed by AML-M2 (25.2%) and AML-M4 (19.9%). Chromosomal abnormalities were identified in 145 (51.42%) of the total AML cases. A high frequency (38.6%) of chromosomal abnormalities was identified in AML-M3 subgroup as compared to AML-M2 (31%) and AML-M4 (20.6%).

Conclusions:

Cytogenetic study is important for the diagnosis and management of the AML patients. Our study identified chromosomal abnormalities in AML subgroups with varied frequencies. It is important in diagnosis and monitoring of the disease. As younger AML patients were more affected in our study, etiological factors such as environmental factors need to be studied. Combination of conventional cytogenetics and FISH has an advantage of identifying high frequency of chromosomal aberrations in AML patients.
Prevalence of Keratoconus and Keratoconus Suspect among Patients Seeking Refractive Surgery in Syria
Authors: Salman Abdelrahman , Darwish Taym , Badla Abdul Aziz , Askar Mohammad , Al-Rufayie Moussa , Ghabra Marwan , Haddeh Yusra , Kailani Obeda , Shaaban Rafea , Hajjo Samer , Hasan Hiba , Ali Ali
Published: June 2023

PURPOSE:

The purpose of this study was to determine the prevalence of keratoconus (KC) and keratoconus suspect (KCS) among patients seeking refractive surgery in Syria.

METHODS:

This is a retrospective multicenter screening study. The study was conducted in Damascus University, Tishreen University, and Tartous Specialist Eye Center (a private center). Data were collected from refractive surgery candidates referred for preoperative evaluation before laser in situ keratomileusis, photorefractive keratectomy, intrastromal corneal rings, and phakic intraocular lens implantation. Corneal parameters were obtained by Scheimpflug–Placido tomography, Sirius (CSO, Italy).

RESULTS:

A total of 1479 patients were included in this analysis. The prevalence rates of KC and KCS were 18.19% (269/1479) and 13.52% (200/1479), respectively. In addition, patients with KC were found to have higher percentages of eye rubbing and astigmatism than suspect and normal (P < 0.0001).

CONCLUSION:

High prevalence rate of KC was found among patients seeking refractive surgery in Syria. Although this study was carried out on a highly selective population, it may reflect a high prevalence rate in a general population in Syria.
Lipid storage myopathy due to FLAD1 mutation presenting as a floppy baby
Authors: Mathew Rosmin , Hariharan Sankar Vaikom , Sarasan Ajith Krishnan Ananthakrishnan , Sugunan Sheeja
Published: June 2023

Lipid storage myopathy due to flavin adenine dinucleotide synthetase 1 deficiency is an autosomal recessive inborn error of metabolism that includes variable mitochondrial dysfunction resembling multiple acyl-coenzyme A dehydrogenase deficiency (MADD). The phenotype is extremely heterogeneous ranging from a severe disorder presenting in early infancy to a milder course with the onset of muscle weakness in adulthood. There are several studies suggesting riboflavin supplementation tends to improve the clinical outcome, but responses to riboflavin treatment are variable. Here, we describe a 3-month-old boy with flavin adenine dinucleotide synthetase 1 mutation presented as a floppy infant. Lipid storage myopathy with flavin adenine dinucleotide synthetase 1 related MADD, even though rare, should be considered while evaluating a floppy infant because of the scope of availability of treatment, despite variable treatment responses. Therefore, we should have high clinical suspicion, even though the diagnosis is challenging.
An evaluation of clinical outcome of total alloplastic temporomandibular joint replacement and costochondral graft in temporomandibular joint ankylosis cases – A retrospective study
Authors: Mishra Abhishek , Roy Choudhury S. K. , Bhandari S. K. , Pandey Satyanarayan
Published: June 2023

Background:

The temporomandibular joint (TMJ) ankylosis management incorporates various modalities. Total alloplastic temporomandibular joint replacement (TJR) has opened a new avenue in TMJ reconstruction. Costochondral grafts (CCGs) are the gold standard treatment option.

Aim:

This study was designed to compare the clinical outcome between total alloplastic TJR and CCG in TMJ ankylosis cases.

Materials and Methods:

The retrospective data of patients were collected between 2017 and 2020. A total of 12 TJR cases and 8 cases of CCG were included in the study. Maximum mouth opening was recorded in mm and pain score/diet score was recorded on a Visual Analog Score system where 0 was no pain/normal diet and 10 was worse pain/liquid diet. The data were statistically analyzed using the “two-sample t-test (Welch's t-test).”

Results:

The mean interincisal opening in the TJR group was 32.67 (±2.19) and in the CCG group was 33.71 (±4.77). The pain reduction score was better in the TJR group with 0.5 (±0.90) and the diet score was better in the CCG group with 0.714 (±0.95).

Conclusion:

The stock TJR devices have a predictable outcome with a good pain reduction score and an acceptable diet score; however, the autogenous CCG is still better in terms of maximum mouth opening. Although failed CCG cases can be taken up for further correction with the TJR.
Atraumatic myositis ossificans of mentalis muscle
Authors: Govindaraju Roopashri , Ali Sheema H. , Baig Muqeet , Shetty Siri C. N. , Reddy Soundarya Narayana , Jain Vijay
Published: June 2023

Rationale:

Atraumatic myositis ossificans circumscripta is a benign condition characterized by the aberrant formation of bone in extraskeletal soft tissues without a usual connection to trauma.

Patient Concern:

A female patient of around 17 years of age reported with the main complaint of pain and swelling over the chin area for 6 months with no history of trauma.

Diagnosis:

Clinical, radiographic, and histopathological examinations were performed and all signs and symptoms pointed to a diagnosis of Atraumatic Myositis Ossificans in the Mentalis muscle.

Intervention:

Surgical exploration of the area concerned was done under (L.A) local anesthesia with adrenaline (1:1,00,000), where the nodes were extracted from the lower surface of the Mentalis muscle. The wound was sutured back to its normal physiologic anatomy, and the patient then was advised of postoperative instructions.

Results:

The patient recovered with a good prognosis and returned to a normal routine with good functional capacity.

Lessons Learned:

The practitioner must consider Atraumatic Myositis ossificans as a viable diagnosis for painful soft tissue calcification when a history of trauma is not present.
Coronavirus disease 2019 and cardiovascular disease
Authors: Song Jenn-Yeu , Huang Jian-You , Hsu Yi-Chiung , Lo Men-Tzung , Lin Chen , Shen Ta-Chung , Liao Min-Tser , Lu Kuo-Cheng
Published: June 2023

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the coronavirus disease 2019 (COVID-19) pandemic, is a type of RNA virus that is nonsegmented. Cardiovascular diseases (CVDs) increase the mortality risk of patients. In this review article, we overview the existing evidence regarding the potential mechanisms of myocardial damage in coronavirus disease 2019 (COVID-19) patients. Having a comprehensive knowledge of the cardiovascular damage caused by SARS-CoV-2 and its underlying mechanisms is essential for providing prompt and efficient treatment, ultimately leading to a reduction in mortality rates. Severe COVID-19 causes acute respiratory distress syndrome and shock in patients. In addition, awareness regarding COVID-19 cardiovascular manifestations has increased, including the adverse impact on prognosis with cardiovascular involvement. Angiotensin-converting enzyme 2 receptor may play a role in acute myocardial injury caused by SARS-CoV-2 infection. COVID-19 patients experiencing heart failure may have their condition exacerbated by various contributing factors and mechanisms. Increased oxygen demand, myocarditis, stress cardiomyopathy, elevated pulmonary pressures, and venous thrombosis are potential health issues. The combination of these factors may lead to COVID-19-related cardiogenic shock, resulting in acute systolic heart failure. Extracorporeal membrane oxygenation (ECMO) and left ventricular assist devices (LVADs) are treatment options when inotropic support fails for effective circulatory support. To ensure effective COVID-19-related cardiovascular disease (CVD) surveillance, it is crucial to closely monitor the future host adaptation, viral evolution, and transmissibility of SARS-CoV-2, given the virus’s pandemic potential.
Pathophysiology, clinical presentation, and management of ketamine-induced cystitis
Authors: Jhang Jia-Fong , Birder Lori A. , Kuo Hann-Chorng
Published: June 2023

ABSTRACT

Ketamine is illegally used as a recreational drug in many Asian countries. Long-term ketamine abusers often develop irritable bladder symptoms that gradually develop into more severe urinary frequency and urgency and eventually into a painful ulcerated bladder. These patients typically have reduced functional bladder capacity, increased bladder sensation, detrusor overactivity, severe urgency, urinary incontinence, and bladder contracture. Ketamine metabolites can cause severe inflammation of the urothelium, urothelial barrier deficits, vascular endothelial fibrinoid changes, increased oxidative stress, and bladder wall fibrosis. A decrease in bladder compliance, urinary tract infection, severe bladder pain with a full bladder, and painful micturition are also common symptoms. Finally, with continued abuse of ketamine, hydronephrosis, ureteral stricture, vesicoureteral reflux, and renal failure may develop. Cessation of ketamine is the mainstay of treatment. Lower urinary tract symptoms usually relapse if patients reuse ketamine after stopping. In cases of severe ketamine cystitis, only augmentation enterocystoplasty can relieve bladder pain and restore normal lower urinary tract function. This article reviews the underlying pathophysiology, clinical characteristics, and management of ketamine cystitis.
Real Analysis, Harmonic Analysis and Applications
Authors: Christ Michael , Müller Detlef , Thiele Christoph , Vargas Ana
Published: June 2023

The workshop focused on important developments within the last few years in real and harmonic analysis including nonlinear Carleson theorems and singular integral theory, Fourier restriction theory and spherical maximal functions as well as concurrent progress in the application of these for example to partial differential equations.
Algebraic Geometry: Moduli Spaces, Birational Geometry and Derived Aspects
Authors: Hacon Christopher D. , Huybrechts Daniel , Thomas Richard P. W. , Xu Chenyang
Published: June 2023

The workshop covered recent developments in algebraic geometry in a broad sense with a special emphasis on various moduli spaces. Problems related to mirror symmetry phenomena were discussed in a number of talks as well as singularity theory in the context of the MMP in positive characteristic. Derived categories and algebraic cycles, as well as rationality questions figured prominently in the talks and the discussions.
The Renormalization Group
Authors: Bauerschmidt Roland , Disertori Margherita , Hollands Stefan , Salmhofer Manfred
Published: June 2023

The renormalization group was originally introduced as a multiscale approach to quantum field theory and the theory of critical phenomena, explaining in particular the universality observed e.g. in critical exponents. Over the years it has become a powerful tool in the mathematical analysis of systems with infinitely many interacting degrees of freedom. Its applications include quantum field theories, classical and quantum statistical mechanics, (stochastic) partial differential equations, operator theory, and probability theory. For some important problems, it is the only known tool for mathematical proofs. The last few years have seen further important developments, in particular in the application of the method to probabilistic questions, and to equilibrium and non-equilibrium quantum statistical mechanics. This workshop has given an account of the most important new developments in the last five years, including methodical progress, current applications, relations to other approaches, and identified new challenges that may be tackled in future work with the help of the renormalization group.
Non-Commutative Geometry and Cyclic Homology
Authors: Connes Alain , Nest Ryszard , Nikolaus Thomas , Yu Guoliang
Published: June 2023

The meeting displayed the cyclic theory as a fundamental mathematical tool with applications in diverse domains such as analysis, algebraic K-theory, algebraic geometry, arithmetic geometry, solid state physics and quantum field theory.
CORRECTING THE FREQUENCY OF OPERATIONS OF TECHNICAL SERVICE OF MOBILE MACHINES TAKING INTO ACCOUNT THE CLIMATE RIGIDITY
Authors:   Belarusian State Agrarian Technical University, SHCHURIN Konstantin V. , TARASENKO Viktor E. ,   Belarusian State Agrarian Technical University
Published: June 2023

Based on the analysis of the main operational factors, among which, for specific areas of equipment supply, one of the main ones is the climatic factor, as well as the main damaging degradation processes during the operation of machines, an effective mechanism for planning the frequency of maintenance operations is proposed, which helps to ensure a high level of technical readiness of machines. The operability potential was analyzed, its active, reserve and passive parts were considered, which made it possible to present a model for changing and restoring the operability potential of a mobile machine. Mathematical dependences are given for certain models of machines of the same functional purpose, as well as characterizing processes of reducing the potential of their performance in a certain external environment, their transformation is noted when changing natural and climatic operating conditions. The construction of a priori diagram of the ranks of climatic factors made it possible to note that the most significant adverse effect is exerted by temperature, humidity and solar radiation in the operating area. Taking into account the distribution of zones of technical rigidity of the climate, its score and the coefficient of continentality, a method is proposed for correcting the frequency of operations of technical service of transport-technological machines for the zone of their actual operation.
RISK-BASED DESIGN METHODOLOGY FOR ENSURING COMPETITIVENESS IN THE GLOBAL ENGINEERING INDUSTRY
Authors:   Mechanical Engineering Research Institute of the Russian Academy of Sciences, PANOV Alexander N.
Published: June 2023

The article presents materials on the development of risk-based design methodology as a new stage in the development of the system of design, manufacture, operation, maintenance, repair and disposal of equipment for effective and efficient competitiveness in the global engineering industry. It is shown that traditional design is no longer adequate to global planetary changes accompanied by a reduction in resources, design deadlines, entering the market in a competitive environment and a conflicting global division of labor. It is noted that at present, machinery and technology have become much more complicated, including inconnection with embedded software. Attention is focused on the fact that forecasting and evaluation of behavior, reliability and management of compliance with the requirements of sociotechnical systems in connection with the nonlinear processes of functioning of human-machine systems and degradation for both regular and non-standard conditions require innovative methods and tools. Attention is drawn to the fact that the creation of technology is accompanied by an increase in interrelated man-made, natural and social risks, the primary sources of which are inadequate information both when creating and using technology. For a wide practical application of risk-oriented design, a methodology, methods for risk management at the stages of the life cycle of equipment, state standards are suggested, as well as ways to identify the significance of damages in existing forms of design, technological, and other documentation for products and manufacturing processes, as well as in new types of documents, for example, in terms of risk management. It is noted that further work is currently being planned for the widespread introduction of a risk-based approach in mechanical engineering and related industries of both individual countries and unions to ensure the effective competitiveness of supply chains.
INVESTIGATION OF THE STRESS-STRAIN STATE OF VARIOUS TYPES OF MINE SHAFT LININGS IN CARNALLITE ROCK MASS
Authors:   Belarusian State University, ZHURAVKOV Michael A. ,   Belarusian State University
Published: June 2023

The paper considers the mechanical behaviour of a salt rock mass around a mine shaft and analyses the causes for the differences in the nature and speed of deformation relative to the analog object. Assuming a significant effect of carnallite inclusions in rock salt on the physical and mechanical properties of the rock, it is proposed to combine carnallite rocks and rock salt zones with inclusions into a unified modelling medium. It is justified by solving model problems based on monitoring data. Adhering to the proposed approaches, the tasks of the “lining – mass” interaction are solved for the types of fastening regulated by regulatory documents. The values of rock pressure in similar mining and geological conditions on a rigid lining are determined. A forecast is given for the stability time of a rigid combined cast-iron-concrete lining and a pliable block lining made of high-performance concrete.
Peran Ukuran Bank Memoderasi Kecukupan Modal dan Konsentrasi Kepemilikan Terhadap Kinerja Keuangan Bank
Authors: Indradi Rachmat , Taswan Taswan
Published: June 2023

The banking sector is the backbone of the Indonesian economy and has a very important role as a financial intermediary. The purpose of this study is to analyze and explain the effect of capital adequacy on banking performance, the effect of ownership concentration on banking performance, the effect of firm size concentration on banking performance, the role of firm size moderating capital adequacy on banking performance, the role of firm size moderating ownership concentration on banking performance. banking performance. The population used in this study were banking companies listed on the Indonesia Stock Exchange (IDX) during the study period (December 2015 – December 2020). In carrying out this research, the data used are secondary data in the form of historical reports of financial ratios of each banking company listed on the Indonesia Stock Exchange and financial statements in the form of quarterly financial statements of banking companies listed on the IDX which have been published in the period research and record. The results of the analysis are banking performance as proxied by return on assets (ROA) will increase if the CAR variables, ownership concentration and company size do not change (fixed), CAR has a significant positive effect on banking performance (ROA), ownership concentration has no effect on banking performance (ROA), banking size has a significant positive effect on banking performance (ROA), banking size strengthens the relationship between CAR and banking performance (ROA), banking size has no effect on the relationship between ownership concentration and banking performance (ROA).
Pengelolaan Asset Daerah Dengan Minimalisasi “Expected Opportunity Loss”
Authors: Widyastuti Dewi Andini , Basukianto Basukianto
Published: June 2023

Good asset management will contribute greatly to local governments in improving public services. On the other hand, if the management is bad, it will also have a bad impact on the local government. The purpose of this study is to determine the amount of potential lost from assets, constraints in asset management and how to minimize expected opportunity loss in regional asset management. This type of research is a qualitative research with an exploratory level. This means that this study aims to explore broadly about the causes or things that cause something to happen and we don't know yet. The object of this research is the expected opportunity loss in the management of regional assets of the Regional Secretary of Central Java Province. The results showed that EOL in the management of regional assets by the Regional Secretary of Central Java Province through BPKAD fluctuated. EOL in asset management is as follows: 4% in 2019, 30% in 2020 and 17% in 2021 of all potential asset revenues of the Central Java Provincial Government. The EOL level is quite high compared to the target number and total assets owned by the Central Java Provincial Government, resulting in the emergence of expected opportunity loss in terms of regional asset management. The expected opportunity loss condition is due to the low level of absorption of realization of regional asset management income, resulting in arrears from the tenants and due to the impact of covid, some tenants can only pay in 2022.
Perilaku Penggunaan Tik Tok Sebagai Media Promosi Pebisnis
Authors: Saffira Linda , Rahmawan Ginanjar
Published: June 2023

This research aims to see the effect of easy to use, low cost promotion, target advertising on the decision to use Tiktok as a business promotion medium. The number of respondents used is 97 respondents, the sample technique is non-probability sampling and the method uses quantitative because business owners who use tiktok for promotion are infinite. The primary data is obtained by using a questionnaire method distributed to business owners, the data is then processed through the SPSS application. In this study, it was found that the easy to use and low cost promotion variables did not affect the decision to use promotions using Tiktok social media, while the targeted advertising variables had an influence on decisions to use Tiktok social media promotions.
Faktor Yang Mempengaruhi Profitabilitas dan Nilai Perusahaan Sektor Makanan dan Minuman
Authors: Monica Tan , Sunarto Sunarto
Published: June 2023

The purpose of this study is to analyze and explain the effect of good corporate governance and capital structure on profitability, to analyze and explain the effect of good corporate governance, capital structure and profitability on firm value. The type of research used in this study is explanatory research with a quantitative approach, namely by testing the comparative causal relationship of the measured research variables. The results of this study are good corporate governance has no significant effect on profitability, capital structure has a positive effect on profitability, good corporate governance, capital structure and profitability have a positive effect on firm value, profitability does not mediate the effect of good corporate governance on firm value and profitability mediates the effect capital structure on firm value
Analisis Sistem Dan Prosedur Penggajian Serta Pengupahan Dalam Meningkatkan Efektivitas Pengendalian Intern PT Maju Jang Jaya Lubuklinggau
Authors: Ustadi Noorchamid , Sardiyo Sardiyo , Andrinaldo Arisky , Rani Vina Dharvika
Published: June 2023

This research uses descriptive qualitative research. In this study using primary and secondary data sources. The data collection technique used by the researcher is the technique of observation, interviews and documentation from PT. Forward Jang Jaya. Based on the analysis of the payroll and wage accounting system, it can be seen that 1) Functions related to the payroll and wage system at PT. Maju Jang Jaya has not fully carried out their duties properly because of the dual tasks carried out by the finance department / cashier, namely as a maker of payroll and salary lists as well as payment of salaries and wages, documents used in the payroll and remuneration system. PT. Maju Jang Jaya is good enough, but still not perfect because there is no salary envelope document. 2) Bookkeeping payroll system and wage system at PT. Maju Jang Jaya has done enough so that it can support the effectiveness of internal control. The network of procedures that make up the payroll and remuneration system has not been fully effective because employee absenteeism is not supervised by the payroll department, so that it can trigger the risk of absenteeism and the occurrence of errors or other fraudulent acts and the organization. structure of PT. Maju Jang Jaya is not good because it does not separate the function of the payroll maker from the payer of the salary. 3) The authorization system has not fully supported the elements of internal control related to payroll and wages because it has not shown evidence of the accountability of the authorities in it and the implementation of the payroll and wage system at PT. Maju Jang Jaya has not fully implemented healthy practices because employee absenteeism is not supervised by the payroll department.
Pengaruh Store Atmosphere, Product Assortment dan Harga Terhadap Minat Beli Pada Lottemart Center Point Medan
Authors: Simanjuntak Demak Claudia Yosephine , Samosir Edward Nasareth , Simamora Teresia Indah Sari
Published: June 2023

Lotte Mart Center Point Medan is a company engaged in trading services with a wholesale sales system. Lottemart Center Point Medan strives to continue to increase consumer buying interest. The purpose of  research is to find out partially and simultaneously the influence of store atmosphere, product variety, and the price of consumer buying interest at Lotte Mart Center Point Medan. The research method used is descriptive quantitative. The independent variables of this research are store atmosphere, product variety, and price. The dependent variable of the study is buying interest. The population technique in this study uses an unlimited population because the population in this study is not possible to be calculated as a whole, so the population is all consumers who visit Lotte Mart Center Point Medan. The sampling method in this study was purposive sampling with a total of 90 people. Data collection techniques were carried out by observation, interviews, and questionnaires. The data were then analyzed using the F test and t test. The results of the study found that store atmosphere, product variety, and prices at Lotte Mart Center Point Medan had an effect on buying interest simultaneously and partially. The magnitude of the influence of store atmosphere, product variety, and price on buying interest at Lotte Mart Center Point Medan is 88.4%, while 11.6% is influenced by variables other than careful variables.
Analisis Niat Beli Kembali Produk Tabungan Emas di Pegadaian Dalam Konteks Omnichannel
Authors: Pasaribu Romindo Megawati , Pasaribu Senti R.O , Sitinjak Imelda , Pasaribu Herry D.S , Matondang Vinsensius
Published: June 2023

Omnichannel is a business model in which its operations and services are integrated in all sales channels owned by the company in one overall system. Omnichannel combines all store marketing channels both online and offline which can make it easier for customers to find information, process, and make decisions in making product purchases. The purpose of this study was to analyze customer engagement as a mediating variable between channel integration quality and repurchase intention on gold savings products at Pegadaian Medan. The sample in this study was 90 respondents and this sampling method used accidental sampling technique. The data analysis method to answer the hypothesis uses SmartPLS 3.0. The results showed (1) Customer engagement in the omnichannel context had a significant effect on repurchase intention, (2) Channel integration in the omnichannel context had no positive and insignificant effect on customer engagement, (3) Channel integration had a positive and significant effect on purchase intention.
Pengaruh Likuiditas, Leverage, Dan Profitabilitas Terhadap Return Saham Pada Perusahaan Manufaktur Pada Sektor Industri Dasar Dan Kimia Yang Terdaftar Di Bursa Efek Indonesia
Authors: Rianto Hartato , Putri Anita
Published: June 2023

This study was conducted to determine how the influence of the current ratio, debt to equity ratio, and return on assets on stock returns in manufacturing companies in the basic and chemical industrial sectors listed on the Indonesia Stock Exchange. Data taken from www.idx.co.id. The data used are from 2014 to 2019. The study was conducted in 2021. The population in this study was 61 companies with 39 companies used as samples. This study uses quantitative data that is processed with the Eviews 9 application with the panel regression method. The test results conclude that only the return on assets variable partially has a significant effect on stock returns, while the current ratio and debt to equity ratio partially have no significant effect on stock returns. Simultaneously, the current ratio, debt to equity ratio, and return on assets also have no significant effect on stock returns of manufacturing companies in the basic and chemical industry sectors. The contribution given by the variable current ratio, debt to equity ratio, and return on assets to stock returns is only 1.20%, while the level of closeness of the variables current ratio, debt to equity ratio, and return on assets to stock returns is not very close.
Debt Financing dan Equity Financing Pada Profit Expense Ratio Perusahaan Bank Syariah di Indonesia
Authors: Amalia Adinda Nani Nur , Hapsari Dian Indriana
Published: June 2023

The study aims to determined the effect of the level of debt financing and equity financing on the profit expense ratio in islamic banks. This study uses a quantitative method with a population of 16 companies. The technique used in this study was purposive sampling, in order to obtain a sample of 6 companies with a total of 12 data spanning the 2018-2021 observation years. The test tool used is Multiple Linear Regression Analysis using SPSS 23. The results show that debt financing has no effect on the profit expense ratio. Meanwhile, equity financing has an influence on the profit expense ratio.
Pengaruh Pengelolaan Lingkungan dan Kenyamanan terhadap Kepuasan Wisatawan di Kampung Wisata Sawah
Authors: Sidabutar Deli Kristina , Hidayat Rahmat
Published: June 2023

In environmental cleanliness, there are many tourist attractions that do not maintain the cleanliness of the environment both from tourists and managers themselves. So that there needs to be awareness to maintain the environment around tourist destinations. This study aims to determine the effect of environmental management and comfort on tourist satisfaction. The sample of this study were 66 tourists of Kampung Wisata Sawah Pematang Johar, Kecamatan Labuhan Deli Kabupaten Deli Serdang Provinsi Sumatera Utara. The data analysis method used in this research is descriptive quantitative, while the data analysis model used in this research is multiple linear regression analysis. This hypothesis testing uses the coefficient of determination test, partial test and simultaneous test. The results of this study indicate that partially and simultaneously environmental management and comfort have no effect on tourist satisfaction in Kampung Wisata Sawah Pematang Johar. This study recommends that tourist attraction managers must maintain tourist satisfaction, especially in terms of managing the environment and comfort, so that this will increase the number of visits. Object managers must be able to manage Kampung Wisata Sawah Pematang Johar better so that the needs of tourists are met, and tourists can come back and even invite other tourists to come visit.
Analisis Pengaruh Pengendalian Kualitas Produk dan Pengendalian Proses Produksi Terhadap Peningkatan Produktivitas Produk
Authors: Putra I Gusti Ngurah Agung Dewantara
Published: June 2023

The purpose of this study was to analyze the influence of product quality control and production process control on increasing product productivity at a pharmaceutical company in Surabaya, East Java. The research design used in this study uses the quantitative associative method, namely the research conducted aims to determine the effect or relationship between the independent variables on the dependent variable. The data collection technique carried out in this study was through observation of the production process carried out with the population used in the study, namely production machines owned by the company while the sample used in this study was 30 production batches that had been controlled for product quality and control of the production process. Data analysis in this study used SPSS software by conducting hypothesis testing which consisted of a coefficient of determination test (R-square) and a partial t test. Based on the results of the data analysis that has been carried out in the first hypothesis (H1), which states that product quality control has a positive and significant effect on increasing product productivity, the t-count value is 14,685 greater than the t-table value, which is 1,701, testing the second hypothesis (H2) which states that control of the production process has a positive and significant effect on increasing product productivity, the t-count value of 13,640 is greater than the t-table value of 1,701, which means that product quality control and production process control have a positive and significant effect on increasing product productivity, while the value The R-square obtained was 0.818 which stated that the variable product quality control and production process control had an effect on increasing product productivity by 81.80% and the remaining 18.20% was influenced by other variables.
Peran Digitalitasi Ekonomi Untuk Membentuk Kemandirian Ekonomi Pondok Pesantren
Authors: Majid Abdulloh , Noviarita Heni , Anggraeni Erike
Published: June 2023

Economic developments have made various economic sectors enter the digital era. Various economic sectors, both on a macro and micro scale, are starting to use digital technology in carrying out their business activities. This is done in order to develop its business activities and survive in an increasingly complex market. Darul Muttaqin Al-Islami Islamic Boarding School is an Islamic-based educational institution which has a business unit and starts using digital technology. The purpose of this study is to look at the role of digitalization in the economic independence of Islamic boarding schools. The research method used is quantitative with research field research. The sampling method uses purposive sampling or sampling with criteria. The number of samples in this study was 100 samples with data collection methods in the form of questionnaires. The results of the study show that digitalization has an effect on economic independence at the Darul Muttaqin Al-Islami Islamic boarding school. This is evidenced by the value of tcount > ttable (5.874 > 1.29007) and the effect of economic digitalization of 37.9% on the economic independence of Islamic boarding schools. This situation shows that the importance of increasing digitalization in the Darul Muttaqin Al-Islami Islamic Boarding School given its positive benefits.