bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum and urinary cadmium and zinc profiles in breast cancer patients and their association with estrogen and HER-2 receptors, and redox status
Authors: Matin Mehrnoush , Salehcheh Maryam , Ahmadzadeh Ahmad , Khorasgani Zahra Nazari , Khodayar Mohammad Javad
Published: March 2023

Background: Cadmium, a metal implicated in environmental toxicity, is linked to tumor growth and cancer. On the other hand, zinc plays an essential function in oxidative stress and can counteract cadmium toxicity and carcinogenicity.
This research aims to evaluate the urine and serum values of cadmium and zinc in breast cancer (BC) patients and their association with estrogen (ER) and HER-2 receptors, and redox status.
Methods: Forty BC patients and thirty healthy subjects participated in this study. Cadmium and zinc levels were measured in serum and urine samples by atomic absorption spectrophotometer. Redox status markers were determined by calorimetric methods.
Results: The amount of cadmium in the BC patients was substantially greater than in the healthy subjects. Zinc levels were significantly lower in patients with BC compared to controls. Breast cancer patients with ER-positive tumors had significantly higher urinary cadmium concentrations (U-Cd) compared to patients with ER-negative tumors. There was no significant difference between the parameters of redox status and the value of cadmium and zinc between patients with BC in the HER-2 subgroup. Malondialdehyde levels in the serum were substantially greater in BC patients than in healthy subjects. Total thiol level and the activity of catalase and superoxide dismutase in serum were considerably lower in BC patients than in healthy subjects.
Conclusions: Breast cancer etiology may be influenced by disturbing redox state and element levels. Increasing U-Cd and lowering zinc levels in the serum could be the risk factors for BC.
Two modified adaptive parameter conjugate gradientmethods for unconstrained optimization
Authors: Luo Wenjun , Wu Zezhong
Published: March 2023

In this work, several convex combinations of conjugate gradient methods are proposed. The parameters of convex combinations are based on memory-less BFGS method. We prove the global convergence of these algorithms under Wolfe condition and compare it with others conjugate gradient method using the CUTEst library. The results show that the proposed algorithm is more efficient and robust than the classical algorithm.
Non-radial ground state solutions for fractional Schrödinger–Poisson systems in ℝ2
Authors: Che Guofeng , Sun Juntao , Wu Tsung-fang
Published: March 2023

Note: Please see pdf for full abstract with equations.
In this paper, we study the fractional Schrödinger–Poisson system with general nonlinearity as follows:
(−∆)su + u + l(x)φu = ƒ(u) in R2,
(−∆) tφ = l(x)u2 in R2,
where 1/2 < t ≤ s < 1, the potential l ∈ C(R2, R+) and the nonlinearity ƒ ∈ C(R,R) does not require the classical (AR)-condition. When l(x) ≡ µ > 0 is a parameter, by establishing new estimates for the fractional Laplacian, we find two positive solutions, depending on the range of µ. As a result, a positive ground state solution with negative energy exists for the non-autonomous system without any symmetry on l(x). When l(x) is radially symmetric, we show that the symmetry breaking phenomenon can occur, and that a non-radial ground state solution with negative energy exists. Furthermore, under additional assumptions on l(x), three positive solutions are found. The intrinsic differences between the planar SP system and the planar fSP system are analyzed.
2020 Mathematics Subject Classification. Primary: 35B38; Secondary: 35J60
The Importance of Plant Signs in Local Environmental Knowledge Construction and its Implications for Conservation of Landscape and Natural Resources in a Savanna Forest (Caatinga) in Brazilian Northeastern: A Biosemiotic Approach
Authors: Silva Arthur Lima , Mira Feliciano
Published: March 2023

This study investigated the role of plant signs in environmental knowledge construction in the quilombola community Baixa dos Quelés (Bahia, Brazil) and the implications of such knowledges in the conservation of natural resources. Plant signs play a central role in local environmental knowledge construction, participating in the forecast of climatic conditions, predicting rainy season, selecting cultivated species, indicating soil types, and pinpointing water resources. However, such informative networks are not taken into consideration in scientific studies, which instead choose classical methods for conducting flora inventory.
Analysis of different criteria and simulation parameters influence on three-dimensional plasticity induced crack closure loads
Authors: Baptista R. , Infante V.
Published: March 2023

Fracture due to fatigue crack growth is still a prevalent failure mode in both brittle and ductile materials. While experimental procedures are fundamental to capture material behaviour in the presence of structural damage, numerical models allow for accessible fracture mechanics analysis. When dealing with crack tip plasticity induced phenomena, characterized by high strain and stress field gradients, only very refined meshes around the crack tip can produce accurate results. Therefore, optimized mesh parameters must be used, in order to achieve high quality models with low computational costs. In the present study, a three-dimensional model for a middle tension specimen has been developed, and the influence of the element size and simulated plastic wake over the resulting crack closure loads was determined. The numerical accuracy is analysed regarding the estimated stress and strain fields, stress intensity factors, plastic zone shape and size and crack opening and closure values. Two different crack sizes were analysed, for a constant load amplitude. The optimal parameters to be used include a minimum element size around 60 times smaller than the resulting plastic zone and a simulated plastic wake of about 60% of the resulting plastic zone. These parameters can be used with different geometries, in order to predict structural integrity and damage tolerance.
Referral order placement decreases time to transfer to adult congenital heart disease care.
Authors: Burger Debora , Denfeld Quin , Evers Patrick , Ward Pam , Woods Patricia , Hasan Reem
Published: March 2023

Background
Pediatric patients with moderate and great complexity congenital heart disease (CHD) may benefit from coordinated transfer to adult congenital heart disease (ACHD) centers to reduce the risk of complications; however, there are a variety of transfer practices. We examined the impact of referral order placement at the last pediatric cardiology visit on time to transfer to an ACHD center.
Methods
We analyzed data collected from pediatric patients with moderate and great complexity CHD who were eligible to transfer to our tertiary center’s accredited ACHD center. We examined transfer outcomes and time-to-transfer between those with a referral order placed at the last pediatric cardiology visit and those without using Cox proportional hazards modeling.
Results
The sample (n = 65) was 44.6% female and mean age at study start was 19.5 years (± 2.2). Referral orders were placed for 32.3% of patients at the last pediatric cardiology visit. Those who had a referral order placed at the last visit had significantly higher number of successful transfers to the ACHD center compared to those who did not (95% vs 25%, p < 0.001). In a Cox regression model, placement of a referral order at the last pediatric cardiology visit was associated significantly with a sooner time to transfer (HR 6.0; 95% CI 2.2–16.2, p > 0.001), adjusting for age, sex, complexity, living location, and pediatric cardiology visit location.
Conclusions
Placement of a referral order at the last pediatric cardiology visit may improve transfer occurrence and time to transfer to accredited ACHD centers.
Mechanical model establishment and energy characteristics analysis for rock material considering the dynamic disturbance effect
Authors: Feng Chenchen , Wang Zhiliang , Wang Jianguo , Li Songyu
Published: March 2023

An element mechanical assembly model was established with the combined modeling method to study the dynamic damage behaviors of deep rock. In this model, the effect of disturbance and pre-static loading on the rock mechanics and statistical parameters was considered and a modified function was introduced to deduce the damage evolution function, thus a mechanical model of rock was established. This model was verified against the relevant experimental and bibliographic data. The results show that the damage evolution rate curve gradually moves to the right along the strain axis and the peak value of curve decreases first and then increases with increasing parameter k. When k is large, the damage evolution rate appears a “plateau” which is more obvious as k gets higher. This “plateau” may correspond to the damage stable development stage. Further, the pre-static loading can improve the resistance to impact of rock. The released energy of rock in the rebound under pre-static loading is higher than that under no pre-static loading with the constant disturbance frequency. It decreases with disturbance numbers rising as the pre-static loading remains unchanged, which indicates the resistance to impact of rock is weakened by adding disturbance frequency. These predictions were consistent with test data in pre-peak stage of “rebound” type curve. For strain-softening type curves, this model did not only fit preferably with test data in the pre-peak stage but also had high fitting accuracy in the post-peak stage. This model can well characterize the mechanical properties and stress-strain behaviors of rock under the combination of static loading and frequent disturbance. These results can provide certain references for the evaluation of the safety and stability of deep rock engineering under high ground stress and frequent dynamic disturbance.
The induction of potent anti-tumor efficacy in diffuse intrinsic pontine glioma by YF-PRJ8-1011 of a novel cyclin-dependent kinase 4/6 inhibitor
Authors: Zuo Pengcheng , Li Yaopeng , Wang Tantan , Lin Xingyu , Wu Zhen , Zhang Junting , Liao Xuebin , Zhang Liwei
Published: March 2023

Objective
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brainstem tumor. Despite numerous efforts to improve survival benefits, its prognosis remains poor. This study aimed to design and synthesize a novel CDK4/6 inhibitor YF-PRJ8-1011, which exhibited more potent antitumor activity against a panel of patient-derived DIPG tumor cells in vitro and in vivo compared with palbociclib.
Methods
Patient-derived DIPG cells were used to assess the antitumor efficacy of YF-PRJ8-1011 in vitro. The Liquid chromatography tandem-mass spectrometry (LC-MS/MS) method was used to measure the activity of YF-PRJ8-1011 passing through the blood-brain barrier. DIPG patient-derived xenograft models were established to detect the antitumor efficacy of YF-PRJ8-1011.
Results
The results showed that YF-PRJ8-1011 could inhibit the growth of DIPG cells both in vitro and in vivo. YF-PRJ8-1011 could well penetrate the blood-brain barrier. It also significantly inhibited the growth of DIPG tumors and prolonged the overall survival of mice compared with vehicle or palbociclib. Most notably, it exerted potent antitumor efficacy in DIPG in vitro and in vivo compared with palbociclib. In addition, we also found that YF-PRJ8-1011 combined with radiotherapy also showed more significant inhibition of DIPG xenograft tumor growth than radiotherapy alone.
Conclusion
Collectively, YF-PRJ8-1011 is a novel, safe, and selective CDK4/6 inhibitor for DIPG treatment.
Learning performance of grey mouse lemurs (Microcebus murinus) during a visual discrimination task: effect of the stimuli’s emotional value
Authors: Mortessagne Eugénie , Bovet Dalila , Nozières Camille , Pouydebat Emmanuelle , Pifferi Fabien
Published: March 2023

While the interaction between emotions and cognition is relatively well known in humans, it remains to be explored in non-human primates, whose dedicated studies are carried out on a limited diversity of species, preventing us from discussing the evolutionary origin of this interaction. Here, we explored this cognition-emotion interaction in the grey mouse lemur (Microcebus murinus), often described as possessing ancestral characteristics, allowing us to better comprehend if this link appears soon in the phylogeny of primate. We tested whether emotions could modify the learning performance of 60 mouse lemurs during a visual discrimination task. In this task, individuals had to learn to discriminate between two platforms using emotionally valued visual stimuli and to jump on the target platform. Our results showed that individuals learning performance improved when distractors had an emotional valence compared to when they were neutral. Opposite, individuals had impaired learning performance when targets had an emotional valence compared to when they were neutral. These results are consistent with the cognitive avoidance pattern for negative stimuli reported in other studies. This study is the first to explore emotion in mouse lemurs and to demonstrate that the emotion-cognition interaction is already present in a lemur’s species.
HBAC Algorithm for Enhancement of Makespan and improved Task allocation for VM in cloud datacenter
Authors: Ullah Arif , Alam Tanweer , Abbasi Irshad Ahmed , ŞAHİN Canan BATUR , Abualigah Laith
Published: March 2023

Regardless of the past research work in cloud computing some of the challenges still exist related to workload distribution in cloud data centers. Especially in the infrastructure as a service IaaS cloud model. Efficient task allocation is a crucial process in cloud data center due to the restricted number of resource and virtual machines (VM). IaaS is one of the main models of cloud computing because this model handles the backend where servicer like VM and data centers are managed. Cloud service providers should ensure high service delivery performance in such models avoiding situations such as hosts being overloaded or under loaded as this result causes VM failure and make higher network execution time. Therefore, to overcome these problems, this paper proposed an improved load balancing technique known as the HBAC algorithm which dynamically allocates resources by hybridizing the Artificial Bee Colony (ABC) algorithm with the Bat algorithm. The proposed HBAC algorithm was tested and compared with other state-of-the-art algorithms on 200-20000 even tasks by using CloudSim on standard workload format (SWF) data sets file size (200kb and 400kb). The proposed HBAC showed an improved accuracy rate in task distribution of VM in a cloud datacenter and reduced the makespan (energy level) in the datacenter. Based on the ANOVA comparison test results, a 1.98 percent improvement on accuracy or task distribution of VM occurs and 0.98 percent reduced makespan or energy level of cloud data center. The results are consistent with different services broker policies which are used during simulation process for the proposed algorithm in cloud datacenter. In future research the proposed algorithm used for predication approach for resource managements system in cloud data center.
Decoherence as a high-dimensional geometrical phenomenon
Authors: Soulas Antoine
Published: March 2023

We develop a mathematical formalism that allows to study decoherence with a great level generality, so as to make it appear as a geometrical phenomenon between reservoirs of dimensions. It enables us to give quantitative estimates of the level of decoherence induced by a purely random environment on a system according to their respectives sizes, and to exhibit some links with entanglement entropy.
Detecting Security Bad Smells of Software by using Data Mining
Authors: Alraddadi Sara
Published: March 2023

Bad smells of code can lead to significant software vulnerabilities that negatively affect the security attribute of software and make the software easily attacked. Method implementation is the lowest code level that produces bad smells in software. Several programming guidelines have been introduced to reduce the number of bad code smells. Some are related to security, while others are related to other software quality attributes. We can detect some of these guidelines by using quality metrics (e.g., the number of lines of code and the number of parameters). This project proposes applying data mining classifiers to automatically detect security code smells and non-security code smells based on software quality metrics. We developed eight models using eight classifiers: Logistic Regression, Random Forest, XG Boost, J48, SVM, Naive Bayes, LightGBM, and Neural Network. We evaluated the eight models using several performance measurements (e.g., accuracy and confusion metrics). The results showed that it could detect the security code smell from the non-security code smell with the highest accuracy of 95\%.
Improved Nodal Harvest with Intra-Corporeal Mesentery Dissection in Laparoscopic Right Hemicolectomy: A Retrospective Study
Authors: Naseem Zainab , Ho Kah , Tran Mathew , Hapangama Nipuni , Fitzgerald Kate , Maqbool Abrar , D'Souza Basil , Hargreaves Warren , Jayachandran Narayanan
Published: March 2023

Background
Right-sided colon cancer is now commonly treated by laparoscopic right hemicolectomy (LRH). The best procedure for mesentery dissection and nodal harvesting is still being debated. The purpose of this research is to compare intra-corporeal mesentery dissection (ICMD) with extra-corporeal mesentery dissection (ECMD) approaches and assess their impact on nodal harvest during LRH.
Methods
A retrospective analysis of 78 operative cases of LRH was performed. The patients were divided into two groups: those with ICMD (n = 30) and those with ECMD (n = 48). The total number of lymph nodes extracted was the primary outcome. The number of positive lymph nodes, length of hospital stay, and surgical complications were some of the secondary objectives.
Results
The total number of lymph nodes extracted in the ICMD was considerably higher (p = 0.02). Cancers located in the ascending colon were associated with more lymph nodes than tumours located in the cecum or hepatic flexure (p0.001). The two groups did not differ significantly regarding the median number of positive lymph nodes or length of hospital stay.
Conclusion
This study demonstrates that ICMD provides improved nodal yield compared to ECMD in LRH for right-sided colon cancer. Tumor location also impacts the nodal yield, with tumors in the ascending colon having the highest yield. Understanding the optimal mesentery dissection technique and nodal harvest can help improve the oncological outcomes. The use of robotic surgical equipment may further enhance the ICMD approach, especially for accessing retroperitoneal structures.
A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs
Authors: Jian Rui , Ruan Yan , Wang Jiaqi , Yu Meng , Wang Fengsheng , Wang Jiangjun , Xu Yixiao , Liu Lianlian , Cheng Yuda , Yang Ran , Zhang Chen , Yang Yi , Wang JiaLi , Wu Wei , Chen Guangxing , Huang Yi , Tian Yanping , Zhang Junlei
Published: March 2023

A comprehensive and precise definition of the pluripotency gene regulatory network (PGRN) is crucial for clarifying the regulatory mechanisms in embryonic stem cells (ESCs). Here, after a CRISPR/Cas9-based functional genomics screen and integrative analysis with other functional genomes, transcriptomes, proteomes and epigenome data, an expanded pluripotency-associated gene set is obtained, and a new PGRN with nine sub-classes is constructed. By integrating the DNA binding, epigenetic modification, chromatin conformation, and RNA expression profiles, the PGRN is resolved to six functionally independent transcriptional modules (CORE, MYC, PAF, PRC, PCGF and TBX). Spatiotemporal transcriptomics reveal activated CORE/MYC/PAF module activity and repressed PRC/PCGF/TBX module activity in both mouse ESCs (mESCs) and pluripotent cells of early embryos. Moreover, this module activity pattern is found to be shared by human ESCs (hESCs) and cancers. Thus, our results provide novel insights into elucidating the molecular basis of ESC pluripotency.
Odontoma Composto Erupcionado em Mandíbula: Diagnóstico e Tratamento
Authors: Carvalho Monica Moreno de , Santana Mônica Ribeiro de Oliveira , Silva Renan Lemos da , Oliveira Luana Ferreira , Oliveira Maria Eduarda de Freitas Santana , Simonato Luciana Estevam
Published: March 2023

Introdução: Os odontomas são considerados um tipo de tumor odontogênico hamartoma (anomalia de desenvolvimento), com etiologia ainda incerta, sendo assintomático e descoberto por exames de rotinas, é um dos tumores mais encontrados na cavidade bucal. Objetivo: O objetivo do presente trabalho é apresentar um relato de caso de um odontoma composto erupcionado em mandíbula, analisando o seu diagnóstico e tratamento. Metodologia: Neste artigo faz-se uma revisão da literatura sobre ele, seguido de um caso clínico relatado sobre odontoma composto na região anterior da mandíbula. Relato de Caso: Paciente do sexo masculino, com 22 anos de idade, compareceu ao Centro de Especialidades Odontológicas (CEO) de Fernandópolis/SP encaminhado pelo ortodontista. Ao exame extrabucal nada digno de nota foi verificado. Ao exame intrabucal verificou-se múltiplas massas esbranquiçadas na região lingual dos dentes 33, 34 e 35, sem sintomatologia dolorosa. O exame radiográfico panorâmico trazido pelo paciente mostrou a presença de um conjunto de estruturas semelhantes a dentes, de forma e tamanho variáveis, envoltos por uma zona radiolúcida, sugerindo o diagnóstico de odontoma composto. Foi solicitada tomografia computadorizada para auxiliar no planejamento da intervenção cirúrgica. O material coletado durante a cirurgia foi encaminhado para análise anatomopatológica e o diagnóstico definitivo foi de odontoma composto. Conclusão: Conclui-se que o diagnóstico precoce de Odontoma Composto possibilita maiores chances de intervenções cirúrgicas bem-sucedidas, evitando grandes complicações, e permitindo assim um processo de cicatrização adequado, poupando estruturas nobres e uma completa reabilitação da saúde bucal do paciente.
Black Women in Academe: Progress But No Parity
Authors: Gregory Shiela
Published: March 2023

Many women who have been mentored by male scholars that are intellectually demanding, have been told to cut back on some of the time they devote to teaching and service in order to concentrate on research. While well meaning and possibly appropriate, this masculine perspective mirrors sexist attitudes that are prevalent both within and outside the academy.
Dancing for Self-Knowledge
Authors: Kutcher Joyce
Published: March 2023

Women have not been taught to take care of themselves. They frequently spend their time taking care of everyone and everything else, leaving themselves for last.
Mexican Women Confront Mainstream Policy: Voices from the Colonias Address Family Self-sufficiency
Authors: Vaccaro Georgiana , Lessem Ann
Published: March 2023

The practice of allowing "family self-sufficiency" to become tantamount to the family's adoption of legislated middle class values might limit access to these social services to women who are willing to compromise their own culture.
Barriers to Upward Mobility in InternationalSchools for Women Administrators
Authors: Berman Barbara
Published: March 2023

In order to cultivate the qualitites of effective leadership, women administrators must be challenged to behave in ways beyond the bounds of the conventions of academia when women are obtaining degrees and certification in educational administration, and when women are working in the international school setting, where they do not traditionally have the same opportunities and levels of decision-making that men do.
The Role of Education in Entrepreneurship: Two Canadian Stories
Authors: Lynes Jennifer , Wismer Susan , Andrachuk Mark
Published: March 2023

The role that education and training plays in entrepreneurial success is one that is subject to lively debates in the literature. In the first half of this paper, we explore the essence of this debate, with a particular focus on women entrepreneurs in Canada. In the second half of the paper, we tell the stories of these two Canadian entrepreneurs who have started technology-based businesses and were participants in a unique Canadian non-profit educational enterprise, Shad Valley Centre for Creative Technology. The stories of these two successful entrepreneurs - Thelma Zee, who started a freelance web design business while she was still in high school, and Jennifer Corriero, who started a now world-renowned non-profit organization for youth - aim to shed light on the role they see for education in entrepreneurship. Our cases suggest that personal characteristics are important — persistence, self-confidence, initiative, creative thinking, and as Thelma said, a certain kind of intelligence that isn't really about being "book-smart," although it often includes that too. Our research also asked the question, "Is learning important?"Traditional formal education plays a relatively small role in these two cases and the others that we have gathered through our study. Based on our research, we would argue this reflects the relatively low importance of formal education as specific preparation for entrepreneurship for women. In our stories, the informal learning that young people receive from family and friends was important. Furthermore, participation in the Shad Valley program - its intensity, level of challenge, and focus on experiential and applied learning — played a key role in inspiring these women to take on the entrepreneurial initiatives.
Teaching Leadership to Female Students in Saudi Arabia
Authors: Alexander Neva Helena
Published: March 2023

Education in Saudi Arabia has become a great interest to many of its people. Additionally, women's education and leadership have become a dynamic interest to many. This research gives light to how females perceive and their understanding of leadership at Prince Mohammad Bin Fahd University (PMU). The central focus of this research project was to evaluate the impact of a leadership course on improving leadership outcomes for female students studying at PMU in Saudi Arabia. In order to achieve this goal, a pre-test/post-test quantitative design was employed. The sample for this investigation was drawn from undergraduate female students enrolled in a leadership course at PMU taught by the researcher.
Susceptibility of bacterial species isolated from mares to ozonated sunflower oil
Authors: DOS SANTOS Gabriel Souza , PERPÉTUO Arthur Azevedo , DİAS SOUZA Marcus Vinícius
Published: March 2023

Sunflower oil is known for its therapeutic properties and culinary use. It is an important alimentary source of tocopherol and unsaturated fatty acids, and is used especially for wound healing. Studies on its antimicrobial potential, however, are lacking. The ozonation of oils of vegetable sources has been explored to enhance their therapeutic properties; however, studies that provide evidence of such benefits are still lacking. In the field of veterinary medicine, such data are even more scarce. In this study, the antimicrobial activity of ozonated sunflower oil was compared to that of non-ozonated oil, in an in vitro system, against strains of Staphylococcus aureus and Escherichia coli, isolated from intrauterine lavages of mares with endometritis. Tests were conducted using the minimum inhibitory concentration method. The ozonated oil was effective against S. aureus, whereas it was not against E. coli isolates. Our data open doors for discussion on the use of sunflower oil, with or without ozone treatment, for therapeutic purposes in veterinary medicine.
Black Mulberry (Morus Nigra L.) juice has positive effects on spermatological parameters in male New Zealand White rabbits
Authors: YILDIZ-GULAY ÖZLEM , GULAY MEHMET SUKRU
Published: March 2023

The current study aimed to investigate the possible effects of black mulberry juice (BMJ) consumption on spermatologic parameters, oxidant/antioxidant activity, and seminal plasma testosterone concentrations of male rabbits. Twenty-four healthy adult New Zealand White rabbits were randomly divided into 4 groups (n = 6). By oral gavage, 3.0 mL of distilled water, 0.75 mL BMJ + 2.25 distilled water, 1.50 mL BMJ + 1.5 mL distilled water, and 3 mL BMJ per 1 kg body weight were given daily for 9 weeks to rabbits in the C, LD, MD, and HD groups, respectively. Ejaculates were taken at the beginning and end of the experiments. Progressive motility, sperm concentration, and intact sperm rates were significantly increased especially in MD and HD groups. A significant decrease in malondialdehyde concentrations was apparent due to BMJ consumption. Moreover, there was a marked increase in catalase and glutathione peroxidase levels in the seminal plasma of the MD and HD groups. The current results indicated that, although seminal plasma protein levels and seminal plasma glutathione levels were not altered, overall oral BMJ treatments were able to improve sperm quality and antioxidant states of the male rabbits.
Effect of Additional Progesterone Treatment During Intravaginal Progesterone Priming in AnestrousEwes
Authors: TAKCI ABDURRAHMAN , KIVRAK MEHMET BUĞRA
Published: March 2023

Oestrus induction with intravaginal progesterone is the most preferred method in anoestrus sheep. In previous studies it was argued that the decrease in the progesterone level before the sponge is removed reduces the efficiency. This study aimed to test the hypothesis that additional progesterone treatment during the progesterone priming in anestrous ewes could increase the reproductive efficiency of the induction. The study conducted on 261 Kangal sheep, which were pregnant in autumn and gave birth in spring and breastfed their lambs for about 60-75 days. All animals included in the study were randomly divided into 3 different groups as P-7 (n = 86), P-8 (n = 80) and control (n = 95). At the beginning of the study a progesterone impregnated sponge was placed to all ewes (Day 0). During sponge treatment, an injection of progesterone was given to P-7 and P-8 group 7 and 8 days after the was sponge placed, respectively. As for control group, no additional progesterone was given during sponge treatment. All groups received 500 IU pregnant mare serum gonadotropin at the sponge withdrawal. Ram was introduced to all ewes the 10th days of the study. There was no difference between the groups in terms of estrus rate (P = 0.28), pregnancy rate (P = 0.32) and multiple pregnancy rates (P = 0.38) (P = 0.28). We considered that the main reason for unexpected low progesterone concentration at the end of the treatment might be the result of high feed intake and metabolic rate. On the other hand, this additional dose could be caused by an excessive increase in progesterone levels in the sheep, which could be the reason for the decrease in reproductive parameters. Additional progesterone support during progesteronebased synchronization yielded acceptable results. However, progesterone can be administered in injection form in the earlier days of synchronization or before sponge insertion to obtain better results.
The changing precipitation storm properties under future climate change
Authors: Wang Haijie , Jiang Peng , Zhang Rongrong , Zhao Jiahui , Si Wei , Fang Yong , Zhang Nana
Published: March 2023

Changes in precipitation storm characteristics especially extreme precipitation events have been frequently reported during recent years, which poses great challenges for flood controls of reservoir basins. In this study, we present a comprehensive examination on the evolution of storm properties during two distinct rainy seasons in Changtan Reservoir Basin located on the southeastern coast of China. We compare the differences in storm duration, inter-storm period, the average storm intensity, and with-in storm pattern between the Meiyu flood season (MFS) and typhoon flood season (TFS). We also explore the future projections of these storm properties based on Coupled Model Inter-comparison Project 6 (CMIP6) precipitation outputs. Our results indicate that precipitation storms in TFS exhibit shorter duration and higher average storm intensity than those of MFS, the flood risk in June is mainly due to accumulative precipitation (longer duration), while in July to September, is mainly due to the storms with high intensity. The projected precipitation shows uncertainties for different emission scenarios, especially during TFS. However, the increasing trend of the average storm intensity is relatively consistent, which is supposed to bring more pressure on flood control in the study area. The results can provide a beneficial reference to water resources management.
Does agricultural water-saving policy improve food security? Evidence from the Yellow River Basin in China
Authors: Yang Rui , Xu Hang
Published: March 2023

For our empirical research, the 2012 implementation of China's National Agricultural Water-Saving Outline serves as a quasi-experiment. In addition, one of the main regions in China for grain production is the Yellow River Basin. Based on this, we utilize a Difference-in-Difference (DID) empirical technique to assess the impact of the agricultural water-saving policy on food security using data from prefectures in China's Yellow River Basin from 2000 to 2020. According to the estimated results, grain production has greatly increased as a result of the agricultural water-saving policy. This conclusion still holds when other water-related policies are considered. The agricultural water-saving policy may enhance other input factors in grain production by assuring water demand, which is one possible mechanism of the influence. The empirical results show that the policy indeed increases the water productivity in agricultural production, which will ensure the effective water utilization in agricultural production, and the grain sown area, which is the most important production factor in agriculture. In heterogeneity analysis, the impact of the policy on food security is the largest in the lower reach, followed by the middle reach and the smallest in the upper reach in the Yellow River Basin.
Elements of Merkābāh Mysticism in the Targum Jonathan to the Book of Ezekiel
Authors: Parchem Marek
Published: March 2023

The chariot-shaped throne of God in the heavens (merkābāh) from Ezekiel’s visions (Ezek 1; 10) was the subject of the earliest Jewish mystical speculation. Hence, it is not surprising that there are numerous allusions and references to merkābāh mysticism in the Targum Jonathan to the Book of Ezekiel. This article analyzes Targum texts containing elements of merkābāh mysticism, namely the image of God sitting on the throne-chariot, the appearance and function of the four living beings, God’s glorification by celestial beings, the motif of the mystic ascending/rising to the heavens, the description of God’s glory filling the new Temple, and the motif of the new Jerusalem as a representation of the heavenly city.
Espacios de memoria para dialogar el diseño desde otros lugares
Authors: Orozco-Álvarez Marisol
Published: March 2023

Crear espacios de memoria que permeen el diseño desde otros lugares nos obliga a escuchar las voces de quienes caminan y transitan otros mundos posibles, otras historias tangibles, otras memorias vivas, que fracturan la linealidad y univocidad que se establece en y desde lo disciplinar, a través de las formas de hacer y decir que se corresponden con los programas y la formación profesional. En esta relación, este artículo aborda diversos encuentros académicos, desarrollados en Saberes ancestrales caminando sin prisa; este último, un espacio creado dentro de los procesos que se gestan en el interior del grupo de investigación diseño&sociedad, como un encuentro relacional, para dialogar con las voces de la gente que transita los territorios, habita los lugares, y permean con su visión de mundo otras formas de hacer, de decir, de pensar, de proyectar; otras miradas, hiladas desde realidades y sentires que trenzan lugares de memoria, de encuentro y diálogo constante.
Breve recuento sobre la disolución ontológica del diseño
Authors: Lopera Molano Daniel
Published: March 2023

El Diseño, como práctica particular de revelado tecnológico de la modernidad, construye un mundo hecho de un solo mundo. El proceso y el resultado de esta práctica reproducen constantemente la fragmentación en pedazos. En ello, lo que se va fragmentando es la relacionalidad fuerte con la urdimbre vital. En el presente escrito se expone brevemente una propuesta de acompañamiento a esa forma de revelado que, siendo alumbrada por el diseño ontológico, se orienta a la disolución ontológica del mismo. El acompañamiento opera en el diálogo a partir de una escucha atenta sobre lo que somos, una escucha que no tenga la intención de comprender al otro sino de abrir la posibilidad de percibir a los otros que también podemos ser. Sería un diálogo especular que tiene sentido en tanto pueda ayudar a aclarar nuestro reflejo. Acompañando al diseño a verse reflejado, este completará el ciclo histórico de su devenir.
Dejarse afectar: la afectividad en los diseños otros
Authors: Alcalde Gómez Valentina
Published: March 2023

Este es un artículo reflexivo derivado de mi investigación de maestría titulada «Manifestaciones de la colonialidad y descolonialidad en el diseño social», en la que analicé cómo estas manifestaciones se pueden presentar en la experiencia de diseño de Dexde (Design for Development), una ONGD española, y Kalamissoo, un grupo de tejedoras de palma de rônier con discapacidad de Usuy, Senegal. A partir de mi experiencia viviendo en Usuy, este texto reúne algunas de las conclusiones y reflexiones que propongo en mi tesis, centrándome en dos postulados: diseñar la vida desde los afectos y el tejer juntas para vivir. Estas reflexiones han estado haciendo eco en mi vida post-tesis a partir de vivencias en la biodanza y el budismo. Es así como este artículo también recoge lo que he seguido tejiendo en mi vida y diseños otros.
«Anillo de Inducción Cromática», obra de Carlos Cruz-Diez en La Tadeo: el arte público que democratiza el conocimiento
Authors: Londoño López Felipe César , Gómez Alzate Adriana
Published: March 2023

Con la apertura, en marzo de 2022, de la obra de arte público del artista franco-venezolano Carlos Cruz-Diez, denominada Anillo de Inducción Cromática», la Universidad de Bogotá Jorge Tadeo Lozano marca un hito en la historia del arte urbano en Colombia y entrega a la ciudad y al país un monumental mural de piso, después de 17 años de gestión y una inversión calculada en cerca de 3000 millones de pesos. La entrega también continúa una importante discusión en torno al impacto que las obras de Cruz-Diez, junto a las de otros artistas cinéticos de la región, tienen en Latinoamérica, y su incidencia en la democratización del conocimiento a través de la creación en los espacios públicos.
Расчет разлета мишени для задач оптимизации лазерного ускорения ионов
Authors: Ракитина M.A. , Брантов A.В. , Глазырин С.И.
Published: March 2023

At present, a significant part of experiments on the interaction of high-power short laser pulses with solid targets is faced with the problem of target modification under the action of a nanosecond prepulse. In this paper, a series of hydrodynamic calculations of target irradiation with a nanosecond laser pulse is performed, which describes the plasma density profiles arising during the target expansion as a function of the parameters of the laser prepulse/additional pulse. The results obtained can make it possible to improve the efficiency of ion acceleration in the interaction of short laser pulses with a profiled plasma target.
Фотокаталитическое разложение растворов метилового оранжевого на поверхности нанопористых слоев меди, серебра и их йодидов
Authors: Безруков П.А. , Нащекин А.В. , Сидоров А.И. , Никоноров Н.В.
Published: March 2023

The efficiency of photocatalytic decomposition of methyl orange solutions on the surface of nanoporous layers of copper, silver and their iodides has been studied. It is shows that nanoporous layers on metal substrates have two absorption bands: they absorb radiation in the UV and Vis spectral range. The process of decomposition of methyl orange molecules on the surface of metal-semiconductor nanostructures Cu-CuI and Ag-AgI occurs under the action of UV and Vis irradiation. While transparency of the methyl orange solution increases.
Твердотельная ZnSe-иммерсия для визуализации дефектов внутри алмаза
Authors: Смирнов Н.А. , Левченко А.О. , Кузнецов С.В. , Егоров А.Б. , Шутов В.В. , Данилов П.А. , Настулявичус А.А. , Кудряшов С.И. , Ионин А.А.
Published: March 2023

Using high-temperature lamellar deformation in an argon atmosphere, diamond samples were sealed into an immersion solid-state composition based on ZnSe to visualize the internal structure of diamond in the visible region of the spectrum. The absence of pyrohydrolysis processes at the ZnSe-diamond interface was shown by the following methods: Raman scattering of light, X-ray phase analysis, scanning electron microscopy with energy dispersive analysis. Visualization of graphic images inside the diamond through a five-millimeter layer of solid-state immersion based on ZnSe was made.
Prospect of Islamic Electronic Money in Indonesia: Case Study on the LinkAja Application
Authors: Hasan Zulfikar , Jayanti Endah Dwi , Azlina Nur , Lestari Reski , Muslim Muslim
Published: March 2023

This research conducted to see how the prospects for electronic money in Indonesia, considering the launch of new electronic money launched this year through the LinkAja application. This application has received a fatwa from the National Sharia Council of the Indonesian Ulema Council (DSN-MUI) to be a strong source of law for application in Indonesian society. The emergence of LinkAja electronic money is one of the policies of all stakeholders because the potential of sharia-based electronic money is quite large, apart from Indonesia having the world's largest Muslim population. The method that the author made is a qualitative method besides reading several journals and reading material about Islamic electronic money. The prospect of newly launched electronic money certainly has several challenges and opportunities that can be used as lessons for relevant stakeholders. Apart from the competition with the same applications as conventional-based electronic money, Indonesians are still used to conventional-based electronic money there is when compared to sharia-based systems. Complete support from the government is needed to make this electronic money develop well, apart from being protected by applicable laws and regulations. Promotion and marketing of all LinkAja management are also necessary to expand the reach not only in cities but also in villages.
Possible Pathophysiological Roles of Neurotransmitter Systems in Men With Lifelong Premature Ejaculation: Protocol for a Scoping Review
Authors: Van Raaij Joost Johan , Janssen Paddy Koen Camiel
Published: March 2023

Background

Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders. In the field of LPE, 2 main types of research have been conducted: direct genetic research and pharmacotherapeutic interference of neurotransmitter systems that can relieve the symptoms of LPE in male patients.

Objective

We aim to provide an overview of studies on neurotransmitter systems as the pathophysiological cause of LPE by investigating direct genetic research or pharmacotherapeutic interference that relieves the main symptom of LPE in male patients.

Methods

This scoping review will use the PRISMA-ScR tool (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). In addition, this study will use a peer-reviewed search strategy. Systematic searches will be conducted using 5 scientific databases (Cochrane Database of Systematic Reviews, PubMed or MEDLINE, Cumulative Index to Nursing and Allied Health Literature [CINAHL], EMBASE, and Epistemonikos). Additionally, pragmatic searches for relevant information in gray literature databases will be performed. Two reviewers will independently include relevant studies in a 2-stage selection strategy. Finally, data will be extracted from the studies and charted to summarize relevant study characteristics and key findings.

Results

As of July 2022, we completed the preliminary searches according to the PRESS 2015 guidelines and started to determine the final search terms that we will use in all selected 5 scientific databases.

Conclusions

This scoping review protocol is the first to focus on neurotransmitter pathways in LPE by combining the results from the genetic and pharmacotherapy studies. The results could help identify potential research gaps or target candidate proteins and neurotransmitter pathways in LPE for further genetic research.

Trial Registration

Open Science Framework 10.17605/OSF.IO/JUQSD; https://osf.io/juqsd

International Registered Report Identifier (IRRID)

PRR1-10.2196/41301
The Change in Exergaming From Before to During the COVID-19 Pandemic Among Young Adults: Longitudinal Study
Authors: O'Loughlin Erin K , Sabiston Catherine M , O'Rourke Roxy H , Bélanger Mathieu , Sylvestre Marie-Pierre , O'Loughlin Jennifer L
Published: March 2023

Background

Exergaming may be an important option to support an active lifestyle, especially during pandemics.

Objective

Our objectives were (1) to explore whether change in exergaming status (stopped, started or sustained exergaming, or never exergamed) from before to during the COVID-19 pandemic was related to changes in walking, moderate-to-vigorous physical activity (MVPA) or meeting MVPA guidelines and (2) to describe changes among past-year exergamers in minutes per week exergaming from before to during the pandemic.

Methods

A total of 681 participants (mean age 33.6; SD 0.5 years; n=280, 41% male) from the 22-year Nicotine Dependence in Teens (NDIT) study provided data on walking, MVPA, and exergaming before (2017 to 2020) and during (2021) the COVID-19 pandemic. Physical activity (PA) change scores were described by change in exergaming status.

Results

We found that 62.4% (n=425) of the 681 participants never exergamed, 8.2% (n=56) started exergaming during the pandemic, 19.7% (n=134) stopped exergaming, and 9.7% (n=66) sustained exergaming. Declines were observed in all 3 PA indicators in all 4 exergaming groups. The more salient findings were that (1) participants who started exergaming during COVID-19 reported the highest MVPA levels before and during the pandemic and declined the least (mean –35 minutes/week), (2) sustained exergamers reported the lowest MVPA levels during the pandemic (median 66 minutes/week) and declined the most in MVPA (mean change of –92 minutes/week) and in meeting MVPA guidelines (–23.6%). During the pandemic, starting exergamers reported 85 minutes of exergaming per week and sustained exergamers increased exergaming by a median 60 minutes per week.

Conclusions

Although starting and sustaining exergaming did not appear to help exergamers maintain prepandemic PA levels, exergaming can contribute a substantial proportion of total PA in young adults and may still represent a useful option to promote PA during pandemics.