bluuebunny/crossref_metadata_2025 huggingface dataset:
Racial Disparities in Time From Diagnosis to Treatment for Stage I Non–Small Cell Lung Cancer
Authors: Holmes Jordan A , Chen Ronald C
Published: March 2018

Background

Delay in lung cancer treatment is associated with worse survival outcomes. We examined whether there are racial disparities in time from diagnosis to treatment initiation for stage I non–small cell lung cancer (NSCLC) using data from the National Cancer Data Base, which includes approximately 70% of incident cancer patients across the United States.

Methods

We analyzed 119 184 patients diagnosed with stage I NSCLC from 2008 to 2013. Median times (in days) from diagnosis to treatment initiation for external beam radiation (EBRT), stereotactic body radiotherapy (SBRT), and surgery (inclusive of wedge resection, lobectomy, and pneumonectomy) were calculated separately and compared among white vs African American (AA) patients using the Wilcoxon rank-sum test. Multivariable linear regression assessed racial differences in days to treatment while adjusting for sex, age, insurance status, regional income, Charlson-Deyo comorbidity score, region, facility type, and treatment. Statistical tests were two-sided.

Results

AA patients had a statistically significantly longer median time to treatment for all three treatment modalities: EBRT 54 days (AA) vs 48 days (white, P < .001); SBRT 66 days vs 55 days (P < .001); surgery 31 vs 26 days (P < .001). In addition, 34% AA vs 24% white patients (P ≤ .001) had treatment initiation eight or more weeks after diagnosis. In multivariable analysis, AA patients experienced an average 8.2-day delay compared with white patients (P < .001).

Conclusions

These results shed light on one possible mechanism of the observed racial disparity in mortality outcomes in NSCLC. Future studies are needed to determine if interventions to reduce treatment delays can reduce racial disparities in this disease.
The inception of star cluster formation revealed by [C ii] emission around an Infrared Dark Cloud
Authors: Bisbas Thomas G , Tan Jonathan C , Csengeri Timea , Wu Benjamin , Lim Wanggi , Caselli Paola , Güsten Rolf , Ricken Oliver , Riquelme Denise
Published: March 2018

We present SOFIA-upGREAT observations of [C ii] emission of Infrared Dark Cloud (IRDC) G035.39-00.33, designed to trace its atomic gas envelope and thus test models of the origins of such clouds. Several velocity components of [C ii] emission are detected, tracing structures that are at a wide range of distances in the Galactic plane. We find a main component that is likely associated with the IRDC and its immediate surroundings. This strongest emission component has a velocity similar to that of the 13CO(2–1) emission of the IRDC, but offset by ∼3 km s−1 and with a larger velocity width of ∼9 km s−1. The spatial distribution of the [C ii] emission of this component is also offset predominantly to one side of the dense filamentary structure of the IRDC. The C ii column density is estimated to be of the order of ∼1017–1018 cm−2. We compare these results to the [C ii] emission from numerical simulations of magnetized, dense gas filaments formed from giant molecular cloud (GMC) collisions, finding similar spatial and kinematic offsets. These observations and modellingof [C ii] add further to the evidence that IRDC G035.39-00.33 has been formed by a process of GMC–GMC collision, which may thus be an important mechanism for initiating star cluster formation.
Endoscopic Endonasal Transclival Approach for Resection of a Pontine Glioma: Surgical Planning, Surgical Anatomy, and Technique
Authors: Fernandes Cabral David T , Zenonos Georgios A , Nuñez Maximiliano , Celtikci Pinar , Snyderman Carl , Wang Eric , Gardner Paul A , Fernandez-Miranda Juan C
Published: March 2018

BACKGROUND

The endoscopic endonasal approach (EEA) has been proposed as a potential alternative for ventral brainstem lesions. The surgical anatomy, feasibility, and limitations of the EEA for intrinsic brainstem lesions are still poorly understood.

OBJECTIVE

To describe the surgical planning, anatomy, and technique of an intrinsic pontine glioma operated via EEA.

METHODS

Six-human brainstems were prepared for white matter microdissection. Ten healthy subjects were studied with high-definition fiber tractography (HDFT). A 56-yr-old female with right-hemiparesis underwent EEA for an exophytic pontine glioma. Pre- and postoperative HDFTs were implemented.

RESULTS

The corticospinal tracts (CSTs) are the most eloquent fibers in the ventral brainstem. At the pons, CSTs run between the pontine nuclei and the middle cerebellar peduncle (MCP). At the lower medulla, the pyramidal decussation leaves no room for safe ventral access. In our illustrative case, preoperative HDFT showed left-CST displaced posteromedially and partially disrupted, right-CST posteriorly displaced, and MCP severely disrupted. A transclival exposure was performed achieving a complete resection of the exophytic component with residual intra-axial tumor. Immediately postop, patient developed new left-side abducens nerve palsy and worse right-hemiparesis. Ten days postop, her strength returned to baseline. HDFT showed preservation and trajectory restoration of the CSTs.

CONCLUSION

The EEA provides direct access to the ventral brainstem, overcoming the limitations of lateral approaches. For intrinsic pathology, HDFT helps choosing the most appropriate surgical route/boundaries for safer resection. Further experience is needed to determine the indications and limitations of this approach that should be performed by neurosurgeons with high-level expertise in EEA.
Exploring the origin of broad-band emissions of Mrk 501 with a two-zone model
Authors: Lei Maichang , Yang Chuyuan , Wang Jiancheng , Yang Xiaolin
Published: March 2018

We propose a two-zone synchrotron self-Compton (SSC) model, including an inner gamma-ray emitting region with spherical shape and a conical radio emitting region located at the extended jet, to alleviate the long-standing “bulk Lorentz factor crisis” in blazars. In this model, the spectral energy distributions (SEDs) of blazars are produced by considering the gamma-ray emitting region inverse Compton scattering of both the synchrotron photons itself and the ambient photons from the radio emitting region. Applying the model to Mrk 501, we obtain that the radio emitting region has a comoving length of ∼0.15 pc and is located at sub-parsec scale from the central engine by modeling the radio data; the flux of the Compton scattering of the ambient photons is so low that it can be neglected safely. The characteristic hard gamma-ray spectrum can be explained by the superposition of two SSC processes, and the model can approximately explain the very high energy (VHE) data. The insights into the spectral shape and the inter-band correlations under the flaring state will provide us with a diagnostic for the bulk Lorentz factor of radio emitting region, where the low and upper limits of 8 and 15 are preferred, and for the two-zone SSC model itself. In addition, our two-zone SSC model shows that the gamma-ray emitting region creates flare on the timescale of merely a few hours, and the long time outbursts more likely originate from the extended radio emitting region.
A Dynamically Focusing Cochlear Implant Strategy Can Improve Vowel Identification in Noise
Authors: Arenberg Julie G. , Parkinson Wendy S. , Litvak Leonid , Chen Chen , Kreft Heather A. , Oxenham Andrew J.
Published: March 2018

Objectives:

The standard, monopolar (MP) electrode configuration used in commercially available cochlear implants (CI) creates a broad electrical field, which can lead to unwanted channel interactions. Use of more focused configurations, such as tripolar and phased array, has led to mixed results for improving speech understanding. The purpose of the present study was to assess the efficacy of a physiologically inspired configuration called dynamic focusing, using focused tripolar stimulation at low levels and less focused stimulation at high levels. Dynamic focusing may better mimic cochlear excitation patterns in normal acoustic hearing, while reducing the current levels necessary to achieve sufficient loudness at high levels.

Design:

Twenty postlingually deafened adult CI users participated in the study. Speech perception was assessed in quiet and in a four-talker babble background noise. Speech stimuli were closed-set spondees in noise, and medial vowels at 50 and 60 dB SPL in quiet and in noise. The signal to noise ratio was adjusted individually such that performance was between 40 and 60% correct with the MP strategy. Subjects were fitted with three experimental strategies matched for pulse duration, pulse rate, filter settings, and loudness on a channel-by-channel basis. The strategies included 14 channels programmed in MP, fixed partial tripolar (σ = 0.8), and dynamic partial tripolar (σ at 0.8 at threshold and 0.5 at the most comfortable level). Fifteen minutes of listening experience was provided with each strategy before testing. Sound quality ratings were also obtained.

Results:

Speech perception performance for vowel identification in quiet at 50 and 60 dB SPL and for spondees in noise was similar for the three tested strategies. However, performance on vowel identification in noise was significantly better for listeners using the dynamic focusing strategy. Sound quality ratings were similar for the three strategies. Some subjects obtained more benefit than others, with some individual differences explained by the relation between loudness growth and the rate of change from focused to broader stimulation.

Conclusions:

These initial results suggest that further exploration of dynamic focusing is warranted. Specifically, optimizing such strategies on an individual basis may lead to improvements in speech perception for more adult listeners and improve how CIs are tailored. Some listeners may also need a longer period of time to acclimate to a new program.
Descriptive Analysis of Patient Misidentification From Incident Report System Data in a Large Academic Hospital Federation
Authors: Abraham Paul , Augey Laurence , Duclos Antoine , Michel Philippe , Piriou Vincent
Published: March 2018

Introduction

Patient misidentification continues to be an issue in everyday clinical practice and may be particularly harmful. Incident reporting systems (IRS) are thought to be cornerstones to enhance patient safety by promoting learning from failures and finding common root causes that can be corrected. The aim of this study was to describe common patient misidentification incidents and contributory factors related to perioperative care.

Design and Settings

We retrospectively analyzed IRS data reported by healthcare workers from a large academic hospital federation from 2011 to 2014. All patient misidentification incidents that occurred during perioperative care were reviewed and classified using the international classification for patient safety taxonomy. Incident type, contributory factor, error type, and consequences for the patient and for the organization were extracted for each incident report.

Results

Among the 293 reported incidents, the most frequent errors were missing wristbands (34%), wrong charts or notes in files (20%), administrative issues (19%), and wrong labeling (14%). The main contributory factors included the absence of patient identity control (30%), patient transfer (30%), and emergency context (8%). Data on patient and institutional consequences were scarce. Events of missing and wrong identities on wristbands were rarely detected when patients were transferred from the admission ward to the operating room or the radiology department.

Conclusion

These results illustrate that misidentification errors are still common in France. This work contributes to enhancing interest in IRS data analysis to define or refine patient safety improvement strategies related to misidentification errors in healthcare institutions.
Prevalence of Antibiotic Resistance in Commensal Escherichia Coli among the Children in Rural Hill Communities of North East India
Authors: Singh Ashish Kumar , Das Saurav , Singh Samer , Gajamer Varsha Rani , Pradhan Nilu , Lepcha Yangchen Doma , Tiwari Hare Krishna
Published: March 2018

Commensal bacteria are the representative of the reservoir of antibiotic resistance genes present in a community. Merely a few community-based studies on the prevalence of antibiotic resistance in commensal bacteria have been conducted so far in Southeast Asia and other parts of India. Northeastern India is still untapped regarding the surveillance of antibiotic-resistant genes and prevalence in commensal bacteria. In the present work, the prevalence of antibiotic resistance in commensal Escherichia coli was investigated along with the associated demographic factors in pre-school and school going children in rural areas of Sikkim. A total of 550 fecal E. coli isolates were obtained from children of the age 1-14 years living in different villages at various altitudes of Sikkim from July 2015 to June 2017. Standard antibiotic susceptibility testing of these isolates was performed. A structured questionnaire was designed to study the factors associated with carriage of antibiotic resistance in commensal E. coli isolates among children. Descriptive statistics analysis and a logistic regression model were used to identify the effect of external factors on antibiotic resistance pattern. High prevalence of resistance was found against commonly used antibiotics ampicillin (92%), ceftazidime (90%), cefoxitin (88%), streptomycin (40%) and tetracycline (36%) among the samples examined in our present study. No resistance to chloramphenicol was recorded. Fifty-two percent of the isolates were resistant to the combination of penicillin and quinolone group of antibiotics. Children living in nuclear families showed higher incidence of resistance to ampicillin (63.15%, OR 0.18,95% CI:0.11 – 0.28, p<0.01) while children of mothers having education up to school level displayed higher incidence of ceftazidime (59.27% OR 0.75, 95% CI:0.55 - 1.02, p<0.02). Our study demonstrates a high prevalence of antibiotic-resistant commensal E. coli against the commonly used antibiotics among children in the study area. A close association between different demographic factors and the pattern of carriage of antibiotic-resistant isolates was observed suggesting a concern over misuse of antibiotics and warrants a future threat of emerging multidrug resistant isolates.
Strain-level diversity drives alternative community types in millimeter scale granular biofilms
Authors: Leventhal Gabriel E. , Boix Carles , Kuechler Urs , Enke Tim N. , Sliwerska Elzbieta , Holliger Christof , Cordero Otto X.
Published: March 2018

Microbial communities are often highly diverse in their composition, both at the level of coarse-grained taxa such as genera as well as at the level of strains within species. This variability can be driven by both extrinsic factors like temperature, pH, etc., as well as by intrinsic ones, such as demographic fluctuations or ecological interactions. The relative contributions of these factors and the taxonomic level at which they influence community structure remain poorly understood, in part because of the difficulty of identifying true community replicates assembled under the same environmental parameters. Here, we address this problem using an activated granular sludge reactor in which millimeter scale biofilm granules represent true community replicates whose differences in composition are expected to be driven primarily by biotic factors. Using 142 shotgun metagenomes of single biofilm granules we found that, at the commonly used genuslevel resolution, community replicates varied much more in their composition than would be expected from neutral assembly processes. This variation, however, did not translate into any clear partitioning into discrete community types, i.e. the equivalent of enterotypes in the human gut. However, a strong partition into community types did emerge at the strain level for the most abundant organism: strains of Candidatus Accumulibacter that coexisted in the metacommunity--i.e. the reactor--excluded each other within community replicates. Single-granule communities maintained a significant lineage structure, whereby the strain phylogeny of Accumulibacter correlated with the overall species composition of the community, indicating high potential for co-diversification among species and communities. Our results suggest that due to the high functional redundancy and competition between close relatives, alternative community types are most likely observed at the level of recently differentiated genotypes but not higher orders of genetic resolution.
Conceptual design of CHESS, a new direct-geometry inelastic neutron spectrometer dedicated to studying small samples
Authors: Sala Gabriele , Lin Jiao Y. Y. , Graves Van B. , Ehlers Georg
Published: March 2018

CHESS is a new direct-geometry inelastic spectrometer, which is planned for the Second Target Station (STS) at the Spallation Neutron Source (SNS) in Oak Ridge. It will take full advantage of the increased peak brilliance of the high-brightness STS coupled moderators and of recent advances in instrument design and technology to achieve unprecedented performance for inelastic scattering in the cold energy range. This paper presents a conceptual design that addresses key requirements and technical solutions which are derived directly from the science case and anticipated use of the instrument.
A study on the effect of new prepared amide cationic amphipathic on the corrosion inhibition of API N80 steel pipelines in oil wells industries
Authors: Shaban Samy , Fouda Abd Elaziz , Elmorsi Mohamed , Fayed Tarek , Azazy Omar
Published: March 2018

Purpose

The purpose of this study is to inspect the corrosion inhibition of API N80 steel pipelines in uninhibited solution and inhibited with a synthesized surfactant compound [N-(3-(dimethyl octyl ammonio) propyl) palmitamide bromide] (DMDPP), which is prepared through a simple and applicable method.

Design/methodology/approach

Weight loss was inspected at five different temperatures of 25°C, 30°C, 40°C, 50°C and 60°C Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation were used at room temperature. Density functional theory was used to study the relation between the molecular structure and inhibition theoretically.

Findings

Adsorption of the prepared DMDPP fits the Langmuir isotherm model. The inhibition efficiency of the prepared DMDPP amphipathic inhibitor is directly proportional to temperature increase. Polarization results reveal that the investigated DMDPP amphipathic compound behaves as a mixed-type inhibitor. EIS spectra produced one individual capacitive loop.

Originality/value

The originality is the preparation of cationic surfactants through a simple method, which can be used as corrosion inhibitors in oil production. The synthesized inhibitors were prepared from low-price materials. The work studied the behavior of the synthesized surfactants in inhibiting the corrosion of the steel in an acidic medium. Electrochemical and theoretical studies were presented, besides gravimetric and surface examination.
Performance of SMEs in Tangier: the interface of networking andwasta
Authors: Sefiani Yassine , Davies Barry J. , Bown Robin , Kite Neilson
Published: March 2018

Purpose

The purpose of this paper is to investigate the impact of networking on business performance by uncovering particular and significant methods of pursuing business connections, for small and medium enterprises (SMEs) in Tangier.

Design/methodology/approach

A two-stage design, which incorporated both quantitative and qualitative approaches, was employed in this study. Approaches were employed in succession with the findings from the quantitative phase informing the qualitative phase. Initially, a paper and online survey questionnaire was administered to a population of 365 industrial SMEs to gain some insights on the perceptions of owner-managers of the impact of networking on business performance. Following the quantitative phase, 15 in-depth face-to-face semi-structured interviews were conducted with selected owner-managers of SMEs, forming a judgmental selection, to explore their experiences, beliefs, and attitudes with respect to networking factor.

Findings

Both quantitative and qualitative phases of the study found that networking was a significant factor in influencing the success of SMEs. The concept ofwasta, the Arabic word for connections, emerged from the qualitative phase. Findings show that usingwasta, through politico-business networks is important since it enables access to current information that is crucial for the success of SMEs. The concept ofwastawas also mentioned in relation to financial resources and suppliers. Findings revealed that strong relationships with suppliers enable firms to get financial resources in the form of trade credits. Furthermore, the relationship betweenwastaand human resources was also revealed. Findings showed that owner-managers use their network relations throughwastain order to recruit their staff.

Research limitations/implications

The findings of this study add to the understanding of networking in Arabic countries with the importance ofwastain an economy that functions on relationships. The findings of this study could therefore be useful to international managers to assist their intercultural effectiveness by adjusting to culture-specific networking in Tangier.

Originality/value

This study is among those few studies located in the Middle East North Africa region that explore the performance of SMEs from the perceptions of owner-managers themselves, and not based on aggregate or economic data. It supports previous findings of several studies and contributes additional evidence that suggests the significance ofwastaand its impact on SME success.
Audit report timeliness
Authors: Oussii Ahmed Atef , Boulila Taktak Neila
Published: March 2018

Purpose

The purpose of this paper is to examine whether coordination between external auditors and the internal audit function affect the timeliness of audit reports as proxied by audit delay.

Design/methodology/approach

This study uses a survey of chief internal auditors from Tunisian listed companies to analyze the extent of coordination between IAFs and external auditors. Data spanning a four year period (2011-2014) was collected for 53 listed companies. Further, regression analysis was used to test the hypothesis.

Findings

Results indicate that greater coordination between internal and external auditors results in timelier financial reporting.

Practical implications

Overall, the study makes several important contributions. Findings provide important insights that an IAF acts as a valuable resource to external auditors. The results should be of interest to managers, external auditors and the Tunisian Financial Market Council.

Originality/value

This paper is one of few studies which have examined the association between internal-external audit coordination and timeliness of audit reports in an emerging market. The study makes a meaningful contribution to the corporate governance literature by investigating the influence of internal audit assistance on the delivery of timely audited financial information to the capital market. Results also have policy implications for Tunisian regulators with respect to the promotion of internal auditing best practices.
Strategic implications of Cyprus’ emerging oil and gas industry
Authors: Thrassou Alkis , Papasolomou Ioanna , Demetriou Marlen
Published: March 2018

Purpose

Utilising a substantial volume of reliable international literature, information and positions – as well as many, less credible, local ones – the research analyses and interprets theoretical, secondary and primary data that are specific, relevant or peripheral to Cyprus’ emerging oil and gas industry. The purpose of this paper is to predictively and prescriptively define the industry’s strategic implications; both at the public policy level and the business context.

Design/methodology/approach

This research is purely exploratory and is methodologically based on the review, comparison and interrelation of an extensive array of theoretical and secondary data works; which is reinforced and refined through an injection of primary qualitative work in the form of 20 expert and high-level interviews.

Findings

The findings regarding public management underline the need for transparent and synergistic collaboration between all industry actors, as the means to achieve the obvious associated advantages, but also to prevent these forces from becoming opposing, and consequently destabilising ones. Further implications were identified with regards to employment, incentives, education, funding, but also in relation to communications and perceptions. Regarding implications for businesses the research calls for proactivity, identification of opportunities, pursue of the “first movers’ advantage”; as well as a number of specific actions and approaches.

Originality/value

The value of the research lies in its real-time approach to data gathering and analysis; and aids in the design and decision making regarding the industry for policy makers and businesses. The research bears also global/generic importance as it provides a rare insight to the issues and complexities of a country having to first deal with the discovery of hydrocarbons in its economic zone.
How we can and why we have to reconstruct teaching
Authors: Gruschka Andreas
Published: March 2018

Purpose

The purpose of this paper is to arrest an ongoing didactisation of teaching leading to the disappearance of the original content of knowledge.

Design/methodology/approach

Teaching can only be understood within its inner logic by exploring the individual expression of pedagogical practice in three dimensions: education, formation (Bildung), and didactics.

Findings

The use of sequence analysis is an effective method for the pedagogically based formation of teachers as professionals.

Originality/value

This research exposes evident contradictions between teaching and learning. It advances the view that Lesson Study be seen as the reconstruction of teaching for learning through sequence analysis of lessons.
Teachers’ understanding and concerns about the practices of lesson study in suburb schools in Laos
Authors: Shingphachanh Sommay
Published: March 2018

Purpose

Lesson study is a vital approach to improve teaching and learning that Japanese teachers have been utilizing for a century. Lesson study, however, has only recently been recognized as a teacher development strategy in Laos and started implementing in teacher training colleges (TTCs) in 2015. The purpose of this paper is to investigate the extent to which teachers have gained an understanding of the procedure of lesson study and to reveal their initial concerns about its implementation.

Design/methodology/approach

This research reports on lesson study implementation in a Lao TTC during 2015-2017. Data were collected from 11 classroom observations, lesson study reports, lesson study guidelines, and 70 open-ended questionnaires.

Findings

Data analysis revealed the initial experience of teachers in the suburb schools in applying lesson study to enhance teaching and students’ learning outcomes, and their concerns regarding lesson study procedure including time management, the format of the lesson study report, and collaboration with lesson study facilitators. The importance of lesson study experts to facilitate the teachers’ lesson study became clear. In addition, school principals and administrators have an important role in empowering teachers to engage confidently with lesson study.

Originality/value

This study is the first trial project of school-based training for in-service teachers in a TTC and partner primary schools. The aim of the project is to strengthen and promote collaborative learning. To progress lesson study, it is very important to be sensitive to the teachers’ issues in the early stages of the introduction of lesson study.
Understanding the limits of assessing sustainability at Universidad San Francisco de Quito USFQ, Ecuador, while reporting for a North American system
Authors: Velasco Alexandra , Valencia Melanie , Morrow Samantha , Ochoa-Herrera Valeria
Published: March 2018

Purpose

Universidad San Francisco de Quito, USFQ, completed an assessment study to understand its performance in sustainability in 2012. This study aims to recognize the limitations of applying a North American rating system considering relevant criteria to a South American university and to emphasize the importance and lack of benchmarks available in the region.

Design/methodology/approach

Methodology used for this study is based on the Sustainability Tracking Assessment Rating System (STARS) by AASHE. In December 2013, USFQ joined the Pilot Program that included publicly documenting efforts, sharing feedback and making suggestions for system improvements.

Findings

Data collected by USFQ in 2012 and 2013 illustrate how the status of USFQ as a non-residential, teaching university in Ecuador in a developing country had several challenges while using an evaluation system established for universities within a North American system. The limits of assessing sustainability in South America are associated to its geographical location, the number of students and staff that commute to University and the lack of environmental services and certifications available in Ecuador. There are applicability issues with the use of STARS without performance reports from regional peers that can guide the development of relevant benchmarks for future comparability.

Originality/value

Little research has been conducted in the assessment and tracking of sustainability within universities in South America. This paper is one of the first to address the applicability of a North American self-reporting tool to a South American university.
A novel testing system for biomechanical evaluation of the bone or bone fixator
Authors: Guo Zhanshe , Guo Zhaojun , Liang Xiangdang , Liu Shen
Published: March 2018

Purpose

Biomechanical properties of bones and fixators are important. The aim of this study was to develop a new device to simulate the real mechanical environment and to evaluate biomechanical properties of the bone with a fixation device, including the static force and the fatigue characters.

Design/methodology/approach

In this paper, the device is mainly composed of three parts: pull-pressure transmission system, bending force applying system and torsion applying system, which can successfully simulate the pre-introduced pull-pressure force, bending force and torsion force, respectively. To prove the feasibility of the design, theoretical analysis is used. It is concluded from the simulated result that this scheme of design can successfully satisfy the request of the evaluation.

Findings

Finally, on the basis of the force sensor calibration, the static force experiment and fatigue experiment are carried out using the tibia of the sheep as the specimen. It is concluded from the result that the relationship between the micro displacement and the applied axial force is nearly linear. Under the condition of 1 Hz in frequency, 500 N in loading force and 18,000 reciprocating cycles, the bone fixator can still be in good condition, which proves the feasibility of the design.

Originality/value

Biomechanical properties of bones and fixators are studied by researchers. However, few simulate a real force environment and combine forces in different directions. So a novel system is designed and fabricated to evaluate the biomechanical properties of the bones and fixators. Results of the experiments show that this new system is reliable and stable, which can support the biomechanical study and clinical treatment.
Tourism in mountain areas: the innovative provisions within new French legislation
Authors: Courrèges Marie
Published: March 2018

Purpose

The particularly ambitious law of 28 December 2016 aims to protect and bolster economic vitality in mountain regions. As such, it puts the emphasis on supporting and promoting tourism activities. This analysis offers an opportunity to highlight certain particularly innovative provisions that have genuine legal and practical impact.

Design/methodology/approach

This paper is based on a detailed analysis of the Mountain Act 2 taking into account the point of view of customers and tourism promoters.

Findings

The feelings as to how much Mountain Act 2 will benefit the tourism industry remain mixed. The legislators have tried to provide answers to the new problems and issues faced by mountain communities, but at the same time, many measures are leaving tourism development promoters somewhat disappointed.

Originality/value

This paper discusses the implications of the Mountain Act 2 taking into account the point of view of customers and tourism promoters.
A hedonic price model for ski lift tickets in the Dolomites
Authors: Rosson Sara , Zirulia Lorenzo
Published: March 2018

Purpose

Different, alternative or complementary strategies have been advanced for the rejuvenation of the ski tourism product, thus favoring its economic and environmental sustainability. This paper aims to provide new suggestions by looking at the determinants of ski lift ticket prices in the Dolomites.

Design/methodology/approach

The paper uses a hedonic price model approach, which allows the identification of the relative importance of different attributes on the determination of a product price.

Findings

The model shows that a higher level of investment in modern lifts and snowmaking equipment undertaken by the resort pays off in terms of customers’ perceived value-for-money relationship. The same is not true for investments in the enlargement of the skiable surface or the introduction of night skiing options and illuminated slopes. The authors found evidence that non-participatory activities, such as different winter sports and on-slope entertainment, can improve the customer’s perception of resorts’ quality. Finally, reputation plays an important role in determining the customers’ perception of good value-for-money destinations and deals.

Originality/value

With respect to previous works, the research expands the range of attributes possibly impacting ski lift ticket prices. Identifying crucial elements consumers would be willing to pay for allows managers to re-think and adjust their products and prices accordingly, improving the economic sustainability of the ski tourism product.
Tourists’ perception of landscape attributes in rural tourism
Authors: Osti Linda , Cicero Lucia
Published: March 2018

Purpose

The purpose of this paper is to identify the perception of tourists towards positive and negative landscape features. Its objective is to classify rural tourists into homogenous groups according to their sensitivity towards specific landscape characteristics.

Design/methodology/approach

The work is based on quantitative data collection among tourists spending a vacation at agritourism farms. Altogether, 378 valid questionnaires were collected. A K-mean cluster analysis is conducted to group respondents into homogenous groups.

Findings

The research revealed that tourists particularly enjoy the presence of a landscape comprising orchards, flowery/grassy meadows and vineyards. In contrast, tourists find landscapes that reflects a neglected environment, views of factories and congested roads to be particularly unpleasant. This work has also identified the presence of three different clusters with distinct sensitivity towards landscape attributes: there are tourists who are highly sensitive to both positive and negative attributes, tourists who are highly sensitive to positive attributes but less sensitive to the negative attributes and tourists who are less sensitive to both the positive and the negative attributes.

Originality/value

When discussing issues related to the landscape, the question arises as to how and who should preserve and enhance the landscape for tourism reasons. The results of this research demonstrate that preserving and caring for the environment is imperative to the success of rural tourism.
Microbial biodegradation of biuret: defining biuret hydrolases within the isochorismatase superfamily
Authors: Robinson Serina L. , Badalamenti Jonathan P. , Dodge Anthony G. , Tassoulas Lambros J. , Wackett Lawrence P.
Published: March 2018

Biuret is a minor component of urea fertilizer and an intermediate in s‐triazine herbicide biodegradation. The microbial metabolism of biuret has never been comprehensively studied. Here, we enriched and isolated bacteria from a potato field that grew on biuret as a sole nitrogen source. We sequenced the genome of the fastest‐growing isolate, Herbaspirillum sp. BH‐1 and identified genes encoding putative biuret hydrolases (BHs). We purified and characterized a functional BH enzyme from Herbaspirillum sp. BH‐1 and two other bacteria from divergent phyla. The BH enzymes reacted exclusively with biuret in the range of 2‐11 µmol min−1 mg−1 protein. We then constructed a global protein superfamily network to map structure‐function relationships in the BH subfamily and used this to mine > 7000 genomes. High‐confidence BH sequences were detected in Actinobacteria, Alpha‐ and Beta‐proteobacteria, and some fungi, archaea and green algae, but not animals or land plants. Unexpectedly, no cyanuric acid hydrolase homologs were detected in > 90% of genomes with BH homologs, suggesting BHs may have arisen independently of s‐triazine ring metabolism. This work links genotype to phenotype by enabling accurate genome‐mining to predict microbial utilization of biuret. Importantly, it advances understanding of the microbial capacity for biuret biodegradation in agricultural systems.
Microbial pathways for nitrogen loss in an upland soil
Authors: Zhu Guibing , Wang Shanyun , Li Yixiao , Zhuang Linjie , Zhao Siyan , Wang Cheng , Kuypers Marcel M. M. , Jetten Mike S. M. , Zhu Yongguan
Published: March 2018

The distribution and importance of anaerobic ammonium oxidation (anammox) and nitrite‐dependent anaerobic methane oxidation (n‐damo) have been identified in aquatic ecosystems; their role in agricultural upland soils however has not yet been well investigated. In this study, we examined spatio‐temporal distributions of anammox and n‐damo bacteria in soil profiles (300 cm depth) from an agricultural upland. Monitoring nitrogen (N) conversion activity using isotope‐tracing techniques over the course of one year showed denitrification (99.0% N‐loss in the winter and 85.0% N‐loss in the summer) predominated over anammox (1.0% N‐loss in the winter and 14.4% N‐loss in the summer) and n‐damo (0.6% N‐loss in the winter) in surface soils (0–20 cm). While below 20 cm depth, N‐loss was dominated by anammox (79.4 ± 14.3% in the winter and 65.4 ± 12.5% in the summer) and n‐damo was not detected. Phylogenetic analysis showed that Candidatus Brocadia anammoxidans dominated the anammox community in the surface soil and Candidatus Brocadia fulgida dominated below 20 cm depth. Dissimilatory nitrate reduction to ammonium (DNRA), another nitrite reduction process, was found to play a limited role (4.9 ± 3.5%) in the surface soil compared with denitrification; below 80 cm DNRA rates were much higher than rates of anammox and denitrification. Ammonium oxidation was the main source of
above 80 cm (70.9 ± 23.3%), the key influencing factor on anammox rates, and nitrate reduction (100%) was the main
source below 80 cm. Considering the anammox, n‐damo and denitrification rates as a whole in the sampled soil profile, denitrification is still the main N‐loss process in upland soils.
Two novel decarboxylase genes play a key role in the stereospecific catabolism of dehydrodiconiferyl alcohol in Sphingobium sp. strain SYK‐6
Authors: Takahashi Kenji , Miyake Kyohei , Hishiyama Shojiro , Kamimura Naofumi , Masai Eiji
Published: March 2018

Sphingobium sp. strain SYK‐6 is able to use a phenylcoumaran‐type biaryl, dehydrodiconiferyl alcohol (DCA), as a sole source of carbon and energy. In SYK‐6 cells, the alcohol group of the B‐ring side chain of DCA was first oxidized to the carboxyl group, and then the alcohol group of the A‐ring side chain was oxidized to generate 5‐(2‐carboxyvinyl)‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐7‐methoxy‐2,3‐dihydrobenzofuran‐3‐carboxylate (DCA‐CC). We identified phcF, phcG and phcH, which conferred the ability to convert DCA‐CC into 3‐(4‐hydroxy‐3‐(4‐hydroxy‐3‐methoxystyryl)‐5‐methoxyphenyl)acrylate (DCA‐S) in a host strain. These genes exhibited no significant sequence similarity with known enzyme genes, whereas phcF and phcG, which contain a DUF3237 domain of unknown function, showed 32% amino acid sequence identity with each other. The DCA‐CC conversion activities were markedly decreased by disruption of phcF and phcG, indicating that phcF and phcG play dominant roles in the conversion of DCA‐CC. Purified PhcF and PhcG catalysed the decarboxylation of the A‐ring side chain of DCA‐CC, producing DCA‐S, and showed enantiospecificity towards (+)‐ and (–)‐DCA‐CC respectively. PhcF and PhcG formed homotrimers, and their Km for DCA‐CC were determined to be 84 μM and 103 μM, and Vmax were 307 μmol⋅min−1⋅mg−1 and 137 μmol⋅min−1⋅mg−1 respectively. In conclusion, PhcF and PhcG are enantiospecific decarboxylases involved in phenylcoumaran catabolism.
Unconscious Bias Training: The ‘Silver Bullet’ for Gender Equity?
Authors: Williamson Sue , Foley Meraiah
Published: March 2018

Western Governments concerned about the lack of gender equity in their workforces are increasingly seeking to address the negative effects of unconscious biases on employment decisions to counter the effects of hidden prejudices. Although unconscious bias has received limited attention in the human resource literature, social psychology literature has identified inadequacies with this practice, including that such training may entrench and normalise unconscious biases. We argue that the popularity of unconscious bias training invites agencies to view this practice as a ‘silver bullet’ to achieve gender equity, but that its effectiveness is likely to be limited unless accompanied by sustained interventions to address discrimination. Further, the impacts of unconscious bias training need to be rigorously evaluated to assess whether government resources are being effectively utilised. Consistent with international research, such an evaluation may reveal that unconscious bias training has unintended negative consequences, but that the training can be improved to reduce these consequences.
Rethinking the concept of labour
Authors: Narotzky Susana
Published: March 2018

Is labour a useful concept for anthropology today? This essay attempts to respond theoretically to the challenge that the contributions to this special issue empirically pose. The essay rethinks the concept of labour by addressing three questions that deal with the relation of human work effort and capital accumulation: the first refers to alienation; the second to the difference between abstract and concrete labour; and the third to ambiguity. Over the years, these issues have addressed particular aspects of social reproduction, helping define labour as a concept, albeit a heterogeneous one, that is relationally linked to capital. Dislocation, together with the parallel concepts of dispossession, disorganization, disconnection, and differentiation, emerges prominently in the analyses of contemporary labour transformations and specificities. Finally, the essay engages with seemingly disappearing labour futures and what this means for the concept of labour. What is the value of work for capital and, conversely, the value of labouring for people today?
Bill of Sale Lending: Reforming a ‘Toxic’ Form of Credit
Authors: Swaby Gerald , Kelly Rebecca , Richards Paul
Published: March 2018

The Bills of Sale Acts were enacted in Victorian times as a form of secured credit whereby ‘goods’ owned by a borrower could be assigned under the bill of sale to a lender who would have title to the goods transferred to him. The lender would then allow the borrower to retain possession of the goods in exchange for instalment payments with interest. In the twenty‐first century these bills are most commonly used as ‘logbook loans’ for vehicles with extortionate interest rates and very little protection for individual consumers. This article examines the operational background to the Bill of Sale Acts. It focuses upon particular concerns for consumers and businesses and provides critique of the registration process before examining the proposals and consultations for reform currently before the Law Commission.
Robust Machine Learning Variable Importance Analyses of Medical Conditions for Health Care Spending
Authors: Rose Sherri
Published: March 2018

Objective

To propose nonparametric double robust machine learning in variable importance analyses of medical conditions for health spending.

Data Sources

2011–2012 Truven MarketScan database.

Study Design

I evaluate how much more, on average, commercially insured enrollees with each of 26 of the most prevalent medical conditions cost per year after controlling for demographics and other medical conditions. This is accomplished within the nonparametric targeted learning framework, which incorporates ensemble machine learning. Previous literature studying the impact of medical conditions on health care spending has almost exclusively focused on parametric risk adjustment; thus, I compare my approach to parametric regression.

Principal Findings

My results demonstrate that multiple sclerosis, congestive heart failure, severe cancers, major depression and bipolar disorders, and chronic hepatitis are the most costly medical conditions on average per individual. These findings differed from those obtained using parametric regression.

Conclusions

The literature may be underestimating the spending contributions of several medical conditions, which is a potentially critical oversight. If current methods are not capturing the true incremental effect of medical conditions, undesirable incentives related to care may remain. Further work is needed to directly study these issues in the context of federal formulas.
Community‐based water supplies in Cikarang, Indonesia: are they sustainable?
Authors: Roekmi Raden Ajeng Koesoemo , Baskaran Kanagaratnam , Chua Lloyd HC
Published: March 2018

Community‐based water supply (CBWS) is an example of how a community manages common pool resources (CPR). This results in an alternative approach to solve water supply problems in developing countries by enhancing community participation in managing water supply. This research evaluates the sustainability of five CBWS projects in Cikarang, Indonesia by using Ostrom's design principles, with additional sustainability factors found in the Sustainable Development Goal (SDG) on drinking water and groundwater sustainability. Quinn et al. (2007) criteria were used in the analysis, and the results show that the management of four CBWS institutions were absent and one CBWS institution was weak. With regards to the SDG's drinking water target, the CBWS institutions were unable to comply with safe water standards, and in terms of groundwater sustainability, efforts to monitor and sustain groundwater tables were absent. Results from this research suggest that more focus must be placed on water quality and groundwater sustainability for CBWS projects.