bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereoselective Synthesis, Spectral Characterization, Docking and Biological Screening of Coumarin Derivatives
Authors: Zakia Afzal Zakia Afzal , Naghmana Rashid and Humaira Nadeem Naghmana Rashid and Humaira Nadeem
Published: February 2022

The compounds being synthesized in present research are chiral in nature so for getting enantiopure compounds, stereoselective synthesis was carried out by organocatalysis. The importance of enantiopure compounds can not be overstated because the living systems are chiral in nature and response of enantiomers can be very different in living systems. The organocatalysed synthesis was accumplished using 4-hydroxycoumarin and variously substituted dibenzylideneacetones as reactants and the organocatalyst being used was 9-amino-9-deoxyepiquinine. The range of enantioselectivity achieved was 24-95%. The synthesized compounds were characterized by UV, IR, 1H NMR, 13C NMR, EIMS, UVCD, VCD and Chiral HPLC. The major focus of this research was to develop anticoagulant compounds and therefore the molecular docking studies were carried out with crystal structure of vitamin k epoxide reductase (3kp9) and then screened for in-vitro anticoagulant activity by using warfarin as positive control. Out of six synthesized compounds, four compounds (1,2,5,6) have shown greater binding affinity with 3kp9 than warfarin. In in-vitro anticoagulant studies, all compounds showed improved IC50 values than warfarin. Besides anticoagulant activity, antimocrobial activities were also carried out with six different strains of bacteria and fungi. Compound (5) showed 79% inhibition against Bacillus subtillis and 62 % inhibition against Staphylococcus aureus.
Silver Doped Zinc Oxide Thin Film Production by Thermionic Vacuum Arc (TVA) Technique
Authors: Mehmet zkan Mehmet zkan , Sercen Sadik Erdem Sercen Sadik Erdem
Published: February 2022

In this paper, silver (Ag)doped Zinc Oxide(ZnO) thin films were prepared on glass and silicon substrate by using a thermionic vacuum arc technique. The surface, structural, optical characteristics of silver doped thin films have been examined by X-Ray diffractometer (XRD), field emission scanning emission electron microscopy (FESEM), atomic force microscopy (AFM), and UV-Visible spectrophotometer. As a result of these measurements, Ag, Zn and ZnO reflection planes were determined for thin films formed on Si and glass substrate. Nano crystallites have emerged in FESEM and AFM images. The produced films have low transparency. The optical band gap values were measured by photoluminescence devices at room temperature for thin films produced on silicon and glass substrate. The band gap values are very close to 3.10 eV for Ag doped ZnO thin films. The band gap of un-doped ZnO thin film is approximately 3.3 eV. It was identified that Ag doped changes the properties of the ZnO thin film.
Heavy Metal Resistant Bacteria from Soil as Potential Bioremediation Targets: Isolation, Screening andamp; Biochemical Identification
Authors: Khalid Khan and Zahid Khan Khalid Khan and Zahid Khan
Published: February 2022

This study investigates the role of bacterial species capable of mitigating metal-induced toxicity by bioaccumulation and biotransformation. Study focuses on five metals including Pb+2, Ni+2, Cd+2, Cr+2, and Cu+2 in a range of 50-300and#181;g/ml of concentration initially in qualitative (metal-specific) and subsequently quantitative (dose-specific) approach, but results turned out to be much in favor of a quantitative impact of the study. Thirty 30 bacterial strains from soil were isolated and biochemically identified that showed promising metal-resisting behavior. Identification of bacterial strain was based upon biochemical (phenotypic) method. The isolate number 1, 12, 29 and 30 showed high degree of resistance against all metals of concentration up to 300and#181;g/ml suggesting the potential possibility of these species of bacteria to provide some beneficial tools for bio-mining, and bioremediation as well as removing of metal contaminations from heavy metal contaminated sites.
Utility of Spectroscopic Studies for Quantification of Cefditoren Pivoxil in Commercial Samples
Authors: Salma Ali Al Tamimi Salma Ali Al Tamimi , Norah Sultan Abdulaziz Al Motlaq and Fatma Ahmed Aly Norah Sultan Abdulaziz Al Motlaq and Fatma Ahmed Aly
Published: February 2022

The current study is devoted to suggest new simple spectrophotometric probes for the estimation and quantification of cefditoren pivoxil (CFP) either in authentic or in commercial samples. Three simple kinetic and derivatize sensitive spectrophotometric methods were established. Two kinetic techniques (method A) and (method B) were based on the estimation of CFP using the oxidation properties of alkaline potassium permanganate at ambient temperature and the relation between the reduction in the absorbance of KMnO4 and the added CFP were also investigated. The intensity of absorbance (A) of the colored MnO4- ions were recorded at wavelengths 610 and 525 NM for the two methods, respectively. Method C was based on derivatization of CFP with 1,2-naphthoquinone-4-sulphonate reagent in a basic solution (pH=11) to produce an orange red colored solution exhibited the highest absorption peak (λmax) at 411 nm. The proposed systems displayed linearity over the concentration ranges of 1.0-16.0, 1.0-10.0 and 0.5-7.0 and#181;g mL-1.The suggested systems were validated obeying analytical methodology guidelines and the acceptance criteria for accuracy, precision, linearity, selectivity, and robustness were met in all cases.
Theoretical Study of the Complexation of Lidocaine by α- and β-Cyclodextrins
Authors: Nourredine Meddah Araibi Nourredine Meddah Araibi , Teffaha Fergoug Teffaha Fergoug , Mansour Azayez Mansour Azayez , Cherifa Zelmat Cherifa Zelmat , Jendara Ali Cherif and Youcef Bouhadda Jendara Ali Cherif and Youcef Bouhadda
Published: February 2022

Structure and stability of an eventual inclusion complex formed by Lidocaine and two cyclodextrins (α- and β-CD) were investigated using molecular mechanics and quantum-chemical methods in the gas phase and in water. The molecular docking and quantum chemical calculations results show that no inclusion complex is formed between α-CD and Lidocaine molecule, while the conformational research allowed observing two minimum-energy structures between this molecule and β-CD. From a potential energy scan, a partial inclusion of the two ends of Lidocaine by the secondary face of the cavity of β-CD is observed with a better stability for the complex including the ((-N(C2H5)2) group in it. The minimum energy conformers, obtained by semi empirical method (PM3), have been exposed to fully geometry optimization employing ONIOM2 calculations by combining PM3 method with B3LYP, M06-HF and WB97XD functionals at 6-311G (d,p) basis set. The results show that complexation reactions are thermodynamically favored (Gand#176; ˂ 0) and the inclusion complexes are energetically stables and well structured (Sand#176; ˂ 0). According to the analysis of natural bond orbitals, the Van der Waals interactions are the sole driving forces that ensure the stability of the formed complexes.
Comparative Biocompatibilities of Various Sizes of AgCIT and AgPVP with their Protein Coronas Nanoparticles
Authors: Abdul Hameed Abdul Hameed , Komal Saba Komal Saba , Raheela Taj Raheela Taj , Andaleeb Azam Andaleeb Azam , Rohullah and Amna Paracha Rohullah and Amna Paracha
Published: February 2022

Biocompatibilities of nanoparticles are crucial for biomedical applications. Diverse silver nanoparticles (5 nm, 10 nm, 20 nm, 40 nm and 80 nm) caped with citrate and polyvinylpyrrolidone (PVP) were synthesized and primed their protein coronas. Nanoparticles were characterized with UV-visible spectroscope, Dynamic light scattering (DLS) and Transmission Electron Microscope (TEM). Comparative biocompatibilities were verified and recorded using MTS techniques. Human hepatoma carcinoma HepG2) cell line was used for measuring cytotoxic effect by MTS assays. Deleterious and comparative behaviors of citrate and PVP supported nanoparticles with varied dimensions were investigated and concluded; that citrate caped nanoparticles are comparatively less toxic and independent of size than PVP supported nanoparticles, having increased cytotoxicity with increasing size. The cytotoxic effect of citrate caped and its protein coronas nanoparticles was insignificant, while the boosted concentration of PVP supported nanoparticles enhanced the toxic effect, which endorsed enlarged size and amount of PVP supported nanoparticles. As medicinal precursors, the overwhelming use of PVP nanoparticles should be avoided, and a unique protocol must be designed if its use is crucial and unavoidable.
Kinetics of Electron Transfer Reaction between Co(II) and Chlorate Ions: Experimental and Modeling Study
Authors: Mahwish Mobeen Khan and Syed Mumtaz Danish Naqvi Mahwish Mobeen Khan and Syed Mumtaz Danish Naqvi
Published: February 2022

This research article reports original experimental and modeling detail of kinetics of the electron transfer reaction between Co(II) and chlorate ions in acetic acid solution. Design of experiment methodology has been employed to elucidate the effects of temperature and initial concentrations of reactants on the rate of reaction. Levenberg-Marquardt method has been used to fit processed kinetic data (temperatures, initial concentrations of reactants, and concentrations and rates of production of Co(III)) on to various possible rate equations. This algorithm provides a proficient mean for compensating the capricious effects of the experimental process variables and results in the maximum likelihood estimates of the kinetic parameters. The most significant rate law has been selected, on the basis of statistical analyses of the residuals between the predicted and experimental rates. The analyses suggest that the intrinsic rate of reaction is proportional to first power of chlorate concentration but for Co(II) the order is fractional (0.7455 ≈ and#190;). The effect of temperature on the observed rate constant (precision = 0.02 %) is excellently described by the Arrhenius and Eyring equations and the sluggish nature of the reaction is clearly manifested by the high energy (andgt; 93 kJ/mol), negative entropy (-28.5286 J/mol-K) and very small equilibrium constant of activation. Further fairly negative standard entropy of activation shows there is usually considerable rearrangement of energy among various degrees of freedom during the formation of activated complex and proposes an associative mechanism for formation of the activated complex. This research is performed to develop a kinetic model for the electron transfer reaction between Co(II) and chlorate ion. As a result, a redox couple of Co(II)/Co(III) has been formed which is used as a potent oxidation catalyst in chemical industries.
Влияние университетов на повышение уровня инновационного потенциала региона
Authors: Иноземцева Анастасия Алексеевна
Published: February 2022

В настоящее время инновационное развитие является одним из приоритетных направлений в политике государства и, в частности, региона. Университеты выполняют важные традиционные функции, которые нацелены на повышение качества человеческого капитала, а также приобрели новые функции, направленные на их трансформацию в предпринимательский университет. Теоретическая база понятия «предпринимательский университет» была рассмотрена в модели тройной спирали инновационного развития, где именно вуз является «фундаментом» для первоначального создания инноваций и различных технических разработок, что способствует образованию синергии между акторами. Достаточно слабоизученной остаётся тема влияния университетов на инновационный потенциал региона и экономическое состояние в целом, учитывая, что на сегодняшний день ценность высшего образования постепенно снижается. Целью данного исследования является влияние университетов на уровень инновационного потенциала региона. В результате рассмотрения и авторского дополнения структурных компонент вклада университетов в формирование инновационного потенциала были выявлены основные проблемы при улучшении партнёрских отношений между государством, предпринимательством и вузом. На основании выявленных трудностей был разработан комплекс мероприятий, направленных на их устранение, а также для поддержания и наращивания уровня инновационного потенциала региона.

 

БлагодарностиИсследование выполнено в рамках государственного задания Минобрнауки России (FZWN–2020-0016).
Формирование оптимального инвестиционного портфеля высокотехнологичных проектов в рамках научно-образовательного центра мирового уровня
Authors: Лавриненко Елена Александровна , Бондарева Яна Юрьевна
Published: February 2022

Формирование инвестиционного портфеля высокотехнологичных проектов в рамках научно-образовательного центра мирового уровня является важным этапом разработки инвестиционной стратегии региона, от которого зависит эффективность дальнейших управленческих решений, рост социально-экономических показателей и др. В статье представлена многометодная модель формирования оптимального (диверсифицированного) портфеля глобально- конкурентоспособных, высокотехнологичных инвестиционных проектов, предложенных для реализации в рамках научно-образовательных центров (НОЦ) мирового уровня. Предложена методика оценки степени влияния проектов на территориально-отраслевую социализацию региона. Разработана десятибалльная шкала оценки «возможностей» инвестиционного высокотехнологичного проекта. Предложена система оценки рисков инвестиционных проектов. Представлена модель концептуального инвестиционного высокотехнологичного проекта.

 

БлагодарностиИсследование выполнено в рамках государственного задания НИУ «БелГУ» FZWG-2020–0016, тема проекта «Фундаментальные основы глобальной территориально-отраслевой специализации в условиях цифровизации и конвергенции технологий».
Food futuring in Timor-Leste: Recombinance, responsiveness, and relationality
Authors: Szanto David
Published: February 2022

The pluralistic nature of food culture and food systems produces complex and blended realities for research, often prompting approaches that embrace mixed methods and cross-sector partner­ships. In parallel, calls for the decolonization of research methods have brought attention to the importance of relationality when working with local communities and traditional knowledge hold­ers. This article presents the process and outcomes of the Timor-Leste Food Innovators Exchange (TLFIX), a multifaceted initiative centered on the contemporary and historic foodways of Timor-Leste, including current challenges to individual health, cultural identity, and economic-ecological sustainability brought about by centuries of colo­nial and transnational influence. Conceived within an international development context, TLFIX aimed at building local empowerment, economic development, and social change. Methods included quantitative, qualitative, and material-based ap­proaches, including surveys, storytelling, and culi­nary innovation. As a “consulting academic” on the project, I contributed to the research design, coached team members on storytelling-as-method, and participated in a portion of the work. For the current text, I use the notions of recombinance, respon­siveness, and relationality to interpret our collective experience and to frame an example of carrying out mixed-method and mixed-participant work in com­plex food contexts. As a whole, this example illus­trates ways in which to leave space for improvisa­tion and emergence within food practice and scholarship.
POSTCOVID LIVER DAMAGE IN PATIENTS CIRRHOSIS OF THE LIVER
Authors: Досыбаева Г.Н. , Отумбаева Е.Т. , Рсалиева Ж.М.
Published: February 2022

Хроническое поражение печени как цирроз печени представляет собой серьезное нарушение целостности организма. Присоединение новой вирусной инфекции SARS-CoV-2 дал толчок для молниеносного прогрессирования процесса. Мы провели исследование влияния COVID-19 на цирроз печени различной этиологии. С целью изучения особенности постковидного синдрома, сравнили клинические и лабораторные данные пациентов циррозом печени различной этиологии, имеющие в анамнезе подтвержденный COVID-19 и не имеющие в анамнезе COVID-19. По данным лабораторного исследования у пациентов с COVID-19 в анамнезе, были зарегистрированы тяжелые нарушения поражения печени, о чем свидетельствуют лабораторные данные пациентов. У пациентов клиника постковидного синдрома имела довольно яркую картину. COVID-19 является высоким фактором риска летального исхода. Последствия инфекции может продолжаться длительный период и иметь различные проявления.

Chronic liver damage as cirrhosis of the liver is a serious violation of the integrity of the body. The addition of a new viral infection SARS-CoV-2 gave impetus to the lightning-fast progression of the process. We conducted a study of the effect of COVID-19 on liver cirrhosis of various etiologies. In order to study the features of postcovid syndrome, clinical and laboratory data of patients with cirrhosis of the liver of various etiologies with a history of confirmed COVID-19 and no history of COVID-19 were compared. According to a laboratory study in patients with a history of COVID-19, severe liver damage disorders were recorded, as evidenced by the laboratory data of patients. In patients, the clinic of the bridge syndrome had a rather vivid picture. COVID-19 is a high risk factor for death. The effects of infection can last for a long period and have various manifestations.
COMPLEX REHABILITATION OF PATIENTS WITH CONSEQUENCES OF SPINAL CORD INJURY
Authors: Сагымбаев М.А. , Дженбаев Е.С. , Койчубеков А.А. , Рахманов Б.С. , Нурматов М.К. , Сагымбаев Э.М.
Published: February 2022

Пациенты с последствиями позвоночно-спинномозговой травмы (ПСМТ) составляют один из тяжелейших контингентов в нейрореабилитации. В структуре общего травматизма повреждение позвоночника и спинного мозга встречается до 4% случаев, из которых 80% составляют лица молодого трудоспособного возраста, которые в большинстве случаев стойко утрачивают трудоспособность [1]. Последствия ПСМТ приводят к двигательному дефициту, ограничивающему мобильность и передвижение, поддержание вертикальной позы, выполнение социально-бытовых навыков и самообслуживания; к расстройству тазовых функций, поддерживающих инфекционно-воспалительные осложнения, сексуальную дисфункцию; к трофическим нарушениям. Направленность и объем реабилитационных мероприятий, формирование комплекса методов лечения пациентов со спинальной травмой определяется выраженностью выявленных медико-социальных проблем и адаптационно-компенсаторными возможностями пациента.

Patients with the consequences of spinal cord injury (CSCI) constitute one of the most difficult contingents in neurorehabilitation. In the structure of general injuries, injuries of the spine and spinal cord occur in up to 4% of cases, of which 80% are people of young working age, who in most cases permanently lose their ability to work [1]. The consequences of CSCI lead to a motor deficit that limits mobility and movement, maintaining an upright posture, performing social and everyday skills and self-service; to a disorder of pelvic functions that support infectious and inflammatory complications, sexual dysfunction; to trophic disorders. The focus and scope of rehabilitation measures, the formation of a complex of methods for treating patients with spinal injury is determined by the severity of the identified medical and social problems and the adaptive and compensatory capabilities of the patient.
METHODS OF PHARMACOTHERAPY OF SPASTICITY SYNDROME IN CEREBRAL PALSY (LITERATURE REVIEW)
Authors: Мухамбетова Г.А. , Ахметче А.А. , Демесинова Б.К. , Есентаева С.Б. , Митрохин Д.А.
Published: February 2022

Спастичность является хроническим патологическим состоянием при спастических формах церебрального паралича. Спастичность определяется как зависящее от скорости повышенное сопротивление пассивному растяжению мышц, как неуместная непроизвольная мышечная активность, связанная с параличом центрального двигательного нейрона. Повышение мышечного тонуса ограничивает объем активных и пассивных движений, способствует развитию вторичных мышечно-суставных осложнений. Фармакотерапия синдрома спастичности в детском неврологической практике является актуальной проблемой в связи с ограничением их применения в детском возрасте, отсутствием исследований с высоким уровнем доказательности.

Spasticity is a chronic pathological condition in spastic forms of cerebral palsy. Spasticity is defined as speed-dependent increased resistance to passive muscle stretching, as inappropriate involuntary muscle activity associated with paralysis of the central motor neuron. Increased muscle tone limits the volume of active and passive movements, promotes the development of secondary musculoskeletal complications. Pharmacotherapy of spasticity syndrome in pediatric neurological practice is an urgent problem due to the restriction of their use in childhood, the lack of studies with a high level of evidence.
RESULTS OF ANALYSES FROM TREATMENT OF THE FRACTURES PELVIC BONES
Authors: Альходжаев С. , Набиев Е.Н. , Аскеров Р.А. , Абуджазар У.М. , Саганаев Н. , Утешов Б.Б. , Мусатаев С.С. , Шербаев А.А. , Картанбаев Б.Б. , Бегалы О.С. , Онгаров Е.Н. , Онгаров Б.Б. , Омар Н.Н. , Асипов С.С.
Published: February 2022

В этой статье проведен анализ лечения 134 больных, обратившихся в клинику с переломами костей таза различной степени тяжести.

In this article, we analyzed the treatment of patients who applied to the clinic of the city clinical hospital №7 with pelvic fractures of varying degrees. It was studied the frequency of using the surgical and conservative methods of treatment and the length staying the patients in the clinic.
EPIDEMIOLOGY OF CYSTIC ECHINOCOCCOSIS IN KAZAKHSTAN
Authors: Абилбек А.А. , Ирискулова Д.Т. , Каулыбекова А.Е. , Курбанова М.И. , Паизова М.Қ. , Рыскулбек Ж.Т. , Мухамеджанов Г.К. , Кұмар А.Б.
Published: February 2022

Кистозный эхинококкоз - заболевание, вызываемое личиночной стадией цестоды Echinococcus granulosus. Согласно последним данным за 2019 год в базе данных смертность уменьшилась, и составила 0,0079 смертей на 100,000 населения Республики Казахстан. В нашем исследовании мы проанализировали 45 медицинских карт с 2019 года по настоящее время. Средний возраст всех исследуемых составил 38,27±14,8: у мужчин - 34,2; у женщин - 42,1. Большое количество пациентов с кистозным эхинококкозом среди населения от 21 до 30 лет.

Cystic echinococcosis is a disease caused by the larval stage of the cestode Echinococcus granulosus. According to the latest data for 2019 in the database, mortality has decreased and amounted to 0.0079 deaths per 100,000 population of the Republic of Kazakhstan. In our study, we analyzed 45 medical records from 2019 to the present. The average age of all the subjects was 38.27 ± 14.8: for men - 34.2; for women - 42.1. A large number of patients with cystic echinococcosis among the population from 21 to 30 years old.
LAMBERT-EATON MYASTHENIC SYNDROME
Authors: Бубуёк А.М. , Кудебаева А.Ж. , Туруспекова С.Т. , Лисник В.С.
Published: February 2022

Миастенический Синдром Ламберта-Итона (МСЛИ) - это нервно-мышечное заболевание, характеризующееся образованием антител к потенциалзависимым кальциевым каналам (ПЗКК), триггером которых является опухолевый процесс (чаще всего мелкоклеточный рак легких) или как первичный аутоиммунный процесс. Характерными клиническими признаками являются проксимальная мышечная слабость, вегетативные симптомы, снижение сухожильных рефлексов, наличие антител к ПЗКК, снижение амплитуды потенциала мышечной активности (М-ответа) в ответ на низкочастотную повторяющуюся стимуляцию. При подозрении на МСЛИ пациентам требуется тщательное обследование и динамическое наблюдение.

Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular junction disorder in which antibodies against voltage-gated calcium channels (VGCC) arise as a result of a cross-reaction with an underlying tumor (most frequently small lung cell carcinoma), or as a primary autoimmune process. The clinical criteria are proximal muscle weakness, autonomic symptoms, reduced tendon reflexes, positive VGCC antibodies and repetitive nerve stimulation abnormalities. Once the suspicion of LEMS arises, patients require thorough investigations and diligent monitoring.
DYNAMICS OF ULTRASONIC AND DOPPLEROMETRIC PARAMETERS IN THE BACKGROUND OF COMPLEX TREATMENT IN PATIENTS WITH MISCARRIAGE ASSOCIATED WITH THE SYNDROME OF "THIN" ENDOMETRY
Authors: Мамедалиева Н.М. , Лялькова И.А. , Курманова А.М. , Мошкалова Г.Н. , Анартаева Г.Ж.
Published: February 2022

В статье представлены результаты обследования 30 пациенток с невынашиванием беременности в анамнезе и «тонким» эндометрием в сравнении с 20 пациентками без репродуктивных потерь и наличием нормальной толщины эндометрия. На фоне комплексной терапии, включающей элиминацию патогенных возбудителей, внутриматочную УЗ кавитацию и персонифицированную гормональную терапию с использованием трансдермальных эстрогенов и микронизированного прогестерона (Лютеина) интравагинально, исследовалась динамика УЗИ параметров эндометрия. До лечения у пациенток с невынашиванием беременности наблюдалось уменьшение толщины эндометрия. После комплексной терапии отмечено увеличение толщины эндометрия: М-эхо с 5,4±0,6 до 10,3 ±1,7; увеличивалась частота визуализации сосудов матки до 80-100%; в спиральных артериях достоверно снижался пульсационный индекс - PI (1,43±0,04 против 0,79±0,06), индекс резистентности RI (0,96±0,05 против 0,54±0,04), систоло/диастолическое соотношение - S/D в маточных (4,5±0,04 против 2,3±0,05) и аркуатных артериях (3,67±0,04 против 2,41±0,02).

The article presents the results of checking up 30 patients with a history of miscarriage and "thin" endometrium in comparison with 20 patients without reproductive loss and the presence of normal endometrial thickness. Against the background of complex therapy including the elimination of pathogenic agents, intrauterine ultrasound cavitation and personalized hormonal therapy using transdermal estrogens and micronized progesterone (Luteina) intravaginally was studied the ultrasound changes of endometrial parameters. Before treatment patients with miscarriage were found to have decreased endometrial thickness. An increase in the thickness of endometrium has been noted after comprehensive therapy: M-echo from 5.4 ± 0.6 to 10.3 ± 1.7; the frequency of visualization of uterine vessels increased to 80-100%; in the spiral arteries, the pulsation index significantly decreased - PI (1.43 ± 0.04 versus 0.79 ± 0.06), resistance index RI (0.96 ± 0.05 versus 0.54 ± 0.04), systole / diastolic ratio - S / D in the uterine (4.5 ± 0.04 versus 2.3 ± 0.05) and arcuate arteries (3.67 ± 0.04 versus 2.41 ± 0.02).
BASIC PRINCIPLES OF INTENSIVE CARE FOR CHILDREN WITH BURNS OF THE UPPER RESPIRATORY TRACT
Authors: Турлекиева Ж.М. , Султанкулова Г.Т. , Смагулова Д.У.
Published: February 2022

Ожоги дыхательных путей являются одним из наиболее тяжелых поражений органов дыхания и пищеварительного тракта. У детей на фоне комплексной терапии отмечалось ускорение заживления ожоговой раны слизистой ротоглотки и гортани, укорочение времени пребывания больных в отделении реанимации, снижение гнойно-воспалительных осложнений. Применение разработанного комплекса лечебных мероприятий с соблюдением индивидуального подхода к лечению позволило улучшить показатели терапии, исхода лечения, снизить частоту осложнений.

Respiratory tract burns are one of the most severe injuries to the respiratory and digestive tract. Accelerated healing of burn wounds in the mucous membrane of the oropharynx and larynx, shortening the time of stay of patients in the intensive care unit, and a decrease in the rate of pyoinflammatory complications were noted in children against the background of complex therapy. The use of the developed set of therapeutic measures in compliance with an individual approach to treatment has led to an improvement in therapy indicators, treatment outcome, to reduce the frequency of complications.
TYPES AND METHODS OF SURGICAL TREATMENT OF RECTAL CANCER
Authors: Кузикеев М.А. , Нұратаев А.Д. , Мухаметова С.П. , Турсунов Р.Б. , Кусманов М.Е.
Published: February 2022

В данной статье изучены непосредственные результаты хирургического лечения больных раком прямой кишки. Были использованы различные варианты хирургических резекций прямой кишки, которые носили радикальный характер. Частота послеоперационных осложнений составила 20,2%. Проведение неоадьювантной лучевой или химиолучевой терапии не влияет на повышение частоты послеоперационных осложнений.

The immediate results of surgical treatment of patients with colorectal cancer were studied in this article. A variety kinds of radical surgical resection of the rectum were used. The frequency of postoperative complications was 20.2%. Conducting neoadjuvant radiotherapy or chemoradiotherapy has no effect on increasing the frequency of postoperative complications.
FEATURES OF BRAIN CIRCULATION IN PATIENTS WITH CHRONIC HEART FAILURE
Authors: Гафуров Б.Г. , Хайриева М.Ф.
Published: February 2022

С целью изучения мозгового кровообращения у больных с хронической сердечной недостаточностью было обследовано 77 больных из которых 42 больных составили основную группу с различными степени тяжести заболевания. Всем было проведено РЭГ исследования. Результаты показали, что увеличение тяжести клинических проявлений ХСН ассоциируются с постепенно прогрессирующими нарушениями церебральной гемодинамики и связаны как со снижением сократительной способности миокарда, так и нарушением способности церебральных артерий к вазодилатации на фоне более высокого периферического сосудистого сопротивления в мозговых артериях.

In order to study cerebral circulation in patients with chronic heart failure, 77 patients were examined, of which 42 patients constituted the main group with varying degrees of severity of the disease. All of them underwent REG studies. The results showed that an increase in the severity of clinical manifestations of CHF is associated with gradually progressive disorders of cerebral hemodynamics and is associated with both a decrease in myocardial contractility and a violation of the ability of cerebral arteries to vasodilate against a background of higher peripheral vascular resistance in cerebral arteries.
CLINICAL FEATURES OF EPILEPTIC CONDITIONS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA
Authors: Ахророва Ш.Б. , Раупова Н.Ш.
Published: February 2022

Изучена клинические и нейрофизиологические особенности эпилепсии, развывшейся на фоне хронической ишемии головного мозга у 152 больных в возрасте от 45 до 83 лет. При неврологическом осмотре у всех обследованных пациентов были обнаружены органические неврологические симптомы, объединенные в синдромы: пирамидный синдром 90,8 %, мозжечковый синдром 35,1%, экстрапирамидный синдром 89,7%, чувствительные расстройства 2.9%. Установлено, что у пациентов с хронической ишемией головного мозга развивается симптоматическая (структурная) фокальная эпилепсия, при этом развитие простых парциальных припадков отмечено у 10,3% пациентов, сложных парциальных - у 25,9%, вторично- генерализованных - у 30,5%, полиморфных приступов - у 21,8%.

The clinical and neurophysiological features of epilepsy developed against the background of chronic cerebral ischemia in 152 patients aged 45 to 83 years were studied. Neurological examination revealed organic neurological symptoms in all examined patients, combined into syndromes: pyramidal syndrome 90.8%, cerebellar syndrome 35.1%, extrapyramidal syndrome 89.7%, sensory disorders 2.9%. It was found that patients with chronic cerebral ischemia develop symptomatic (structural) focal epilepsy, while the development of simple partial seizures was noted in 10.3% of patients, complex partial seizures - in 25.9%, secondary generalized - in 30.5%, polymorphic attacks - in 21.8%.
A CHANGE IN VIEWS OF ESSENTIAL TREMOR (Literature review)
Authors: Шидерова Г.Б. , Каримова А.С. , Амраева Г.Т.
Published: February 2022

Эссенциальный тремор - одно из наиболее распространённых заболеваний нервной системы. Но, несмотря на это, данная патология до конца не изучена до сих пор. За последние годы с проведением различных исследований с участием пациентов с данной патологией, развитием новых технологий стало появляться все больше данных о тех или иных патофизиологических механизмах эссенциального тремора. Многие ученые приходят к тому выводу, что природа данного заболевания гетерогенна. Это в свою очередь объясняет разнообразие клинической картины, которая включает в себя наличие не только моторных признаков таких, как атаксия, нарушение тандемом походки, но и немоторных: депрессия, тревожность, апатия, нарушения слуха, обоняния и др.

Essential tremor is one of the most common diseases of the nervous system. But despite this, to this day, this pathology has not been studied at all. In recent years, with the conduct of various studies of patients with this pathology, the development of new technologies, more and more data on certain mechanisms of the disease began to appear. Many scientists have come to the conclusion that the nature of essential tremor is heterogeneous. This explains the diversity of the clinical picture, which includes the presence of not only motor signs (ataxia, tandem gait disturbance), but also non-motor ones (depression, anxiety, apathy, hearing impairment, smell, etc.).
THE LANGUAGE OF SCIENCE IS THE SUPPORT OF THE STATE LANGUAGE
Authors: Зайсанбаев Т.Қ. , Карипбаева Г.А. , Канленова Б.Н.
Published: February 2022

В статье представлен обзор языка учебников и учебных пособий на казахском языке для студентов педиатрического факультета. Авторы показали основные грамматические ошибки, которые встречаются в учебниках и учебных пособиях, написанных на казахском языке и подробно объяснили их причины. Раскрывается порядок расположения слов в предложении на казахском языке, правильное употребление словосочетаний, составление составных предложений. Также проведен подробный анализ учебников и учебных пособий, отмечены недостатки и ошибки, допущенные в них, разъяснено, как должно быть правильно по законам грамматики казахского языка. Авторы приходят к выводу, что для развития медицинской науки на казахском языке ученые-медики должны работать совместно со специалистами-языковедами.

The survey of languages used in textbooks and manuals in the Kazakh language for students of pediatric faculty is given in this article. The authors present and try to explain the reasons of the main grammatical mistakes which we can see in textbooks and manuals published in Kazakh. They draw the attention to the word order in sentences in Kazakh, the right usage of word combinations, making up sentences. As well the detailed analysis of textbooks and manuals is given, drawbacks and mistakes are reasoned by the rules of the Kazakh language grammar. The authors come to conclusion that to develop medical science in the Kazakh language scientists of medicine have to work jointly with specialists in linguistics.
RISK FACTORS AND TREATMENT OF INFECTION COMPLICATIONS IN SPINAL SURGERY: A LITERATURE REVIEW
Authors: Карчалова А.М. , Бейсенов Б.Б. , Жанайдаров Ж.С. , Бердиходжаев М.С.
Published: February 2022

Определение значимых факторов риска и частоты возникновения гнойно-воспалительных осложнений у пациентов с травмой грудного и поясничного отдела позвоночника является важной областью спинальной хирургии. Целью данного обзора является обобщение и критический анализ имеющихся фактических данных о современных методах лечения гнойно-воспалительных (ГВО) после операций на позвоночнике, как на ранних, так и на поздних сроках, а также аспектах профилактики для предупреждения данных осложнений. Успешное лечение ГВО после спинальных операций основано на ранней диагностике, хирургической очистке всех некротических тканей и интраоперационном получении бактериологических культур для специфической антибактериальной терапии. Усиливающаяся боль часто является единственной жалобой и может привести к задержке в постановке диагноза. Магнитно-резонансная томография (МРТ) и исследование С-реактивный белок (СРБ) наиболее информативны полезны для установления диагноза ГВО. Лечение ГВО сосредоточено на хирургической агрессии для удаления некротических тканей, воспалительного экссудата и выделения бактериальной культуры.

Determination of significant risk factors and the incidence of inflammatory complications in patients with trauma to the thoracic and lumbar spine is an important area of spinal surgery. The purpose of this review is to summarize and critically analyze the available evidence on modern methods of treating surgical site infection (SSI) after spinal surgery, both in the early and late stages, as well as aspects of prevention to prevent these complications. Successful treatment of SSI after spinal operations is based on early diagnosis, surgical cleaning of all necrotic tissues, and intraoperative obtaining of bacteriological cultures for specific antibiotic therapy. Increasing pain is often the only complaint and can lead to a delay in diagnosis. MRI and CRP studies are most helpful in establishing the diagnosis of SSI. Treatment of wound infection focuses on surgical aggression to remove necrotic tissue, inflammatory exudate, and bacterial culture.
MODEL OF PRECISION THERAPY OF BONE-MUSCLE COMPLICATIONS IN CHILDREN WITH TYPE 2 AND 3 SPINAL MUSCLE ATROPHIES
Authors: Шаймурзин М.Р. , Туруспекова С.Т.
Published: February 2022

Для улучшения качества лечебно-диагностических мероприятий актуален комбинаторный подход, включающий этиопатогенетический аспект и всесторонний анализ задействованных уровней повреждения нейромышечной интеграции, с возможностью раннего верифицирования базисного паттерна не только статомоторных нарушений, но и их скелетно-мышечных осложнений, оказывающих негативное влияние на течение и прогредиенцию заболевания и перспективой проактивной прецизионной терапии выявленных нарушений.

To improve the quality of therapeutic and diagnostic measures, a combinatorial approach is relevant, including the etiopathogenetic aspect and a comprehensive analysis of the involved levels of damage to neuromuscular integration, with the possibility of early verification of the basic pattern of not only statomotor disorders, but also their musculoskeletal complications, which has a negative effect on the course and progression of the disease and the prospect of proactive precision therapy for identified disorders.
DIFFERENTIALLY DIAGNOSTIC CRITERIA IN A PATIENT WITH UROGENITAL PATHOLOGY COMPLICATED BY STROKE (clinical case)
Authors: Нурмухамбетова Б.Р. , Алимжан А.М. , Ескалиева А.А. , Демесинова Б.К. , Шалбай А.Ж.
Published: February 2022

Данная статья является представлением клинически сложного случая дифференциальной диагностики острых нарушений мозгового кравообращения и опухолей головного мозга.

This article is a presentation of a clinically difficult case of differential diagnosis of acute disorders of cerebral circulation and brain tumors.
THE EFFECT OF COGNITIVE IMPAIRMENT ON SLEEP QUALITY IN YOUNG ADULTS
Authors: Бокебаев Т.Т. , Касенова А.С. , Тазабекова Г.С.
Published: February 2022

В статье рассматривается влияние когнитивного дефицита на качества сна. Анализ исследование показал, что состояние сна у лиц молодого возраста со снижением когнитивных функций характеризуется «плохим» качеством сна, вследствии пресомнических нарушений «тяжелой» и «очень тяжелой» степени выраженности, интрасомнических и постсомнических нарушений «умеренной степени выраженности».

The article examines the impact of cognitive deficits on sleep quality. The analysis of the study showed that the sleep state in young people with reduced cognitive functions is characterized by" poor "sleep quality, due to presomnic disorders of" severe "and" very severe "severity, intrasomnic and postsomnic disorders of"moderate severity".
Generative Adversarial Network Based on Multi-feature Fusion Strategy for Motion Image Deblurring
Authors: Zhou-xiang Jin Zhou-xiang Jin , Zhou-xiang Jin Hao Qin
Published: February 2022

Deblurring of motion images is a part of the field of image restoration. The deblurring of motion images is not only difficult to estimate the motion parameters, but also contains complex factors such as noise, which makes the deblurring algorithm more difficult. Image deblurring can be divided into two categories: one is the non-blind image deblurring with known fuzzy kernel, and the other is the blind image deblurring with unknown fuzzy kernel. The traditional motion image deblurring networks ignore the non-uniformity of motion blurred images and cannot effectively recover the high frequency details and remove artifacts. In this paper, we propose a new generative adversarial network based on multi-feature fusion strategy for motion image deblurring. An adaptive residual module composed of deformation convolution module and channel attention module is constructed in the generative network. Where, the deformation convolution module learns the shape variables of motion blurred image features, and can dynamically adjust the shape and size of the convolution kernel according to the deformation information of the image, thus improving the ability of the network to adapt to image deformation. The channel attention module adjusts the extracted deformation features to obtain more high-frequency features and enhance the texture details of the restored image. Experimental results on public available GOPRO dataset show that the proposed algorithm improves the peak signal-to-noise ratio (PSNR) and is able to reconstruct high quality images with rich texture details compared to other motion image deblurring methods.

 
Infrared Image Segmentation for Power Equipment Using Linear Spectral Clustering and Maximal Similarity-based Region Merging
Authors: Haiyan Yu Haiyan Yu , Haiyan Yu Jihong Wang
Published: February 2022

The diagnostic method of power equipment based on infrared images is widely used because it has the advantages of non-contact and does not affect the online operation of power equipment. However, in actual using, the power equipment diagnosis method based on infrared image still relies on manual judgment, that is, the detection personnel can judge the fault according to the obtained infrared image of power equipment by experience. This process consumes a lot of time, and the subjectivity is strong, misjudgment rate is higher, which cannot meet the requirements of modern smart grid development. Infrared image of power equipment contains a lot of noise, and the edge is fuzzy. In this paper, we propose a new infrared image segmentation method for power equipment by using linear spectral clustering and maximal similarity-based region merging under complex backgrounds. In this method, the linear spectral clustering algorithm (LSC) is used to segment the image into super-pixels, and the pixels with similar color and distance are clustered to the same center. The calculated OTSU threshold based on the global image is used to pre-label the background of each super-pixel block. The maximum similarity-based region merging algorithm (MSRM) is utilized to merge the super-pixel blocks. Meanwhile, it obtains the target equipment, the over-segmentation and under-segmentation rates are reduced effectively. Finally, the mathematical morphology algorithm is used to post-process the image. Experimental results show that, compared with other algorithms, this new method can obtain more accurate and complete target equipment under complex background.

 
A Modified Residual Network Based on Multi-scale Segmentation for Aerobics Motion Image Recognition
Authors: Xingxing Dai Xingxing Dai
Published: February 2022

Image recognition is an important field in artificial intelligence, it makes use of the computer to conduct image processing, analysis and understanding to recognize a variety of different objects. And it uses a series of enhancement and reconstruction methods to effectively improve the image quality. Traditional deep Convolutional Neural Network (DCNN) not only improves the recognition accuracy, but also reduces the recognition speed. How to improve the speed while maintaining the accuracy has become an important direction in image recognition. In this paper, we propose a modified Residual network based on multi-scale segmentation for aerobics motion image recognition. The new residual network has the characteristics of shorter network length and faster recognition speed. First, it reduces the length of the network and gets a new residual network with seven layers. Then, combining with the multi-scale segmentation method, an image recognition residual network is obtained. Finally, experiments on the CIFAR10 dataset, the results show that the proposed new motion image recognition method has better recognition accuracy and faster recognition speed.

 
Research for Fault Diagnosis Method and System for Diesel Engine Based on ANFIS
Authors: Ying-Ji Liu Ying-Ji Liu , Ying-Ji Liu Qi-Hang Wang , Qi-Hang Wang Hai-Ying Xia , Hai-Ying Xia Xin-Lei Wei , Xin-Lei Wei Hong Jia , Hong Jia Guo-Liang Dong
Published: February 2022

After compliance verification, operating vehicles can enter the road transportation market. Diesel engine is the main power source of these vehicles, there will be some typical faults during the use of diesel engine, which will affect the technical status of vehicles. According to the fault diagnosis problem of diesel engine, a fault diagnosis method based on Adaptive-Network-Based Fuzzy Inference System(ANFIS) was proposed, Subtractive clustering algorithm was used to confirm the original structure of fuzzy inference model, and ANFIS was used to build an original fault diagnosis model of diesel engine. Hybrid algorithm is used to train the parameter of fuzzy rule, and the final model is established. Simulation experiment results show that the modeling algorithm based on subtractive clustering-ANFIS is effective. It has been found that the average error is 7%, the recognition accuracy is 93.33%. Simulation results show that the fitting ability, convergence speed and recognition accuracy of ANFIS model are all superior to back propagation neural networks (BPNN), and much more suitable as diesel engine fault diagnosis model. Finally, an effective fault diagnosis system is developed by using the given method.

 
The System Design and Realization on Invlusive Finance Economic in Fluence based on the Feature Extraction and Data Fusion
Authors: Chao Zhou Chao Zhou
Published: February 2022

Inclusive finance is a financial system that can effectively and comprehensively provide services to all social classes and groups. Design an inclusive financial economic impact system based on feature extraction and data fusion. Based on the perspective of factor market, product market and financial market, the system structure is designed based on the level of information fusion, and the system is divided into data layer, feature layer and decision layer. Collect different information from the sample data of 31 provinces across the country and perform information fusion to establish a regression model to maximize the information retention rate. Explore the influence of the three market development degrees and the development level of inclusive finance on the high-quality development of the regional economy, and improve the robustness of information feature fusion. The results show that the development level of inclusive finance and the development degree of the three markets have a significant role in promoting the high-quality development of the regional economy. Inclusive finance can promote the high-quality development of the regional economy by optimizing the development of the "three markets".

 