bluuebunny/crossref_metadata_2025 huggingface dataset:
Burden, Quality of Life, and Palliative Care for Family Caregivers of Individuals with Advanced Liver Disease: a Systematic Literature Review
Authors: Woodrell Christopher D. , Mitra Arnab , Hamilton Andrew , Hansen Lissi
Published: November 2021

Purpose of Review

Identify and describe prior studies of family caregiver quality of life, health, and burden experienced while caring for patients with advanced liver disease and the possible role of palliative care.

Recent Findings

Thirty-six articles were identified that met inclusion criteria. Studies identified included cross-sectional, longitudinal, and prospective intervention studies, with a high proportion of qualitative and descriptive research. Resulting studies addressed type of family caregiver burden, including physical, psychological, and financial causes of burden, including HE, lack of information and communication, and unpredictability of the disease course. Few prospective studies were identified. The interventions described included nurse-led palliative care, mindfulness-based stress reduction, and coping interventions.

Little has been published on the nature of family caregiving, burden, quality of life, or the role of palliative care for family caregivers of people with advanced liver disease. Prospective studies that address unmet family caregiver needs, including palliative care interventions, are lacking.
Osteocytes and Weightlessness
Authors: Iandolo Donata , Strigini Maura , Guignandon Alain , Vico Laurence
Published: November 2021

Purpose of Review

Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions or in simulated microgravity conditions models on Earth.

Recent Findings

After a brief recall of the main changes in bone mass and osteoclastic and osteoblastic activities in space-related models, this review focuses on the potential role of osteocytes in directing these changes. The role of the best-known signalling molecules is questioned, in particular in relation to osteocyte apoptosis.

The mechanotransduction actors identified in spatial conditions and the problems related to fluid flow and shear stress changes, probably enhanced by the alteration in fluid flow and lack of convection during spaceflight, are recalled and discussed.
Pendler Mobil: Die Verwendung von Mobilfunkdaten zur Unterstützung der amtlichen Pendlerstatistik
Authors: Hadam Sandra
Published: November 2021

Die Verfügbarkeit von kleinräumigen und aktuellen Pendlerverflechtungen sind für politische wie auch kommunale Entscheidungsfindungen von hoher Bedeutung. Aus dem Pendlerverhalten lassen sich Rückschlüsse auf Arbeitsmarktregionen und die Verteilung der Wohnbevölkerung ziehen, was unter anderem zu einer laufenden Verbesserung der Verkehrsinfrastruktur beiträgt. Die dafür notwendigen Daten veröffentlicht die amtliche Pendlerrechnung. Jedoch weist sie Verbesserungspotenzial im Hinblick auf die zeitliche und räumliche Darstellung der Pendlerverflechtungen von Erwerbstätigen sowie eine fachliche Erweiterung hinsichtlich der Bildungspendler auf.

Dieser Artikel beschreibt die mit dem Projekt Pendler Mobil geprüften Erweiterungsmöglichkeiten der amtlichen Pendlerrechnung auf Basis von Quelle-Ziel-Matrizen aus Mobilfunkdaten. Mobilfunkdaten stellen aufgrund ihrer zeitlichen Aktualität und räumlich feinen Auflösung eine robuste Datengrundlage zur flexiblen Abbildung von potenziellen und regelmäßigen Pendlerbewegungen dar. Die potenzielle Leistungsfähigkeit der Mobilfunkdaten ermöglicht damit eine externe Validierung bestehender Pendlerrechnungen oder Pendlerstatistiken sowie eine beiderseitige Ergänzung zur Ermittlung und Darstellungen weiterer Formen des Pendelns der Erwerbsbevölkerung.

Am Fallbeispiel des Bundeslandes Nordrhein-Westfalen werden im Folgenden Gemeinsamkeiten und Unterschiede der übereinstimmenden Pendlerverflechtungen auf Basis von Mobilfunkdaten und der amtlichen Pendlerrechnung erörtert. Dabei gehen wir auf die Herausforderungen der Aufbereitung und Definition geeigneter Mobilfunkdaten durch den Datenanbieter sowie weitere Einflüsse auf die Mobilfunkdaten, wie bspw. durch die zurückgelegte Distanz oder die Verweilzeiten mobiler Aktivitäten, ein. Besonders die Unterschätzung der mobilen Pendlerströme im Vergleich zur amtlichen Pendlerrechnung legt nahe, Modifizierungsansätze der Mobilfunkdaten zu diskutieren. Im Ergebnis können die vorliegenden Mobilfunkdaten potenziell die amtliche Pendlerrechnung durch kleinräumige Pendlerbewegungen in Städten in Form einer erweiterten Zielorts-Bestimmung unterstützen und die Identifizierung von stark frequentierten Arbeitsorten in Städten ermöglichen.
Achieving a ‘Good AI Society’: Comparing the Aims and Progress of the EU and the US
Authors: Roberts Huw , Cowls Josh , Hine Emmie , Mazzi Francesca , Tsamados Andreas , Taddeo Mariarosaria , Floridi Luciano
Published: November 2021

Over the past few years, there has been a proliferation of artificial intelligence (AI) strategies, released by governments around the world, that seek to maximise the benefits of AI and minimise potential harms. This article provides a comparative analysis of the European Union (EU) and the United States’ (US) AI strategies and considers (i) the visions of a ‘Good AI Society’ that are forwarded in key policy documents and their opportunity costs, (ii) the extent to which the implementation of each vision is living up to stated aims and (iii) the consequences that these differing visions of a ‘Good AI Society’ have for transatlantic cooperation. The article concludes by comparing the ethical desirability of each vision and identifies areas where the EU, and especially the US, need to improve in order to achieve ethical outcomes and deepen cooperation.
Clinical expert consensus document on intravascular ultrasound from the Japanese Association of Cardiovascular Intervention and Therapeutics (2021)
Authors: Saito Yuichi , Kobayashi Yoshio , Fujii Kenichi , Sonoda Shinjo , Tsujita Kenichi , Hibi Kiyoshi , Morino Yoshihiro , Okura Hiroyuki , Ikari Yuji , Honye Junko
Published: November 2021

Intravascular ultrasound (IVUS) provides precise anatomic information in coronary arteries including quantitative measurements and morphological assessment. To standardize the IVUS analysis in the current era, this updated expert consensus document summarizes the methods of measurements and assessment of IVUS images and the clinical evidence of IVUS use in percutaneous coronary intervention.
Implicit Metaethical Intuitions: Validating and Employing a New IAT Procedure
Authors: Wagner Johannes M. J. , Pölzler Thomas , Wright Jennifer C.
Published: November 2021

Philosophical arguments often assume that the folk tends towards moral objectivism. Although recent psychological studies have indicated that lay persons’ attitudes to morality are best characterized in terms of non-objectivism-leaning pluralism, it has been maintained that the folk may be committed to moral objectivismimplicitly. Since the studies conducted so far almost exclusively assessed subjects’ metaethical attitudes via explicit cognitions, the strength of this rebuttal remains unclear. The current study attempts to test the folk’s implicit metaethical commitments. We present results of a newly developed Implicit Association Test (IAT) for metaethical attitudes which indicate that the folk generally tend towards moral non-objectivism on the implicit level as well. We discuss implications of this finding for the philosophical debate.
The Gender Gap in Brazilian Entomology: an Analysis of the Academic Scenario
Authors: Hipólito Juliana , Shirai Leila Teruko , Halinski Rosana , Guidolin Aline Sartori , da Silva Dias Pini Nivia , Soares Pires Carmen Sílvia , Querino Ranyse Barbosa , Quintela Eliane Dias , Gouveia Fontes Eliana Maria
Published: November 2021

Although women are about half of world’s population, they are underrepresented in many sectors including academia and the research scenario in general. Gender gap in Entomology has been pointed out in other publications; however, data for Brazil has never been demonstrated. Here we provide a diagnosis for the Brazilian Entomology scenario in order to contribute to propositions towards disentangling the gender gap in general. We analyzed scientometric data for Brazilian Entomology focusing on gender disparity and on personal perceptions related to the gender gap through an online questionnaire. We detected a pervasive gender bias in which the scissor-shaped curve is the most representative effect of it: women were the majority in lower degree stages but the minority in higher degree stages (permanent positions and positions of prestige and power). We also observed mentorship bias and discussed these results in light of intersectionality and the COVID-19 pandemic. Gender differences were perceived differently by the questionnaire respondents considering age, gender, and parenting. With this data and analyses, we have provided elements to stimulate and support change to a healthier and more equitable academic space.
Microbial activity and community level physiological profiles (CLPP) of soil under the cultivation of spring rape with the Roundup 360 SL herbicide
Authors: Jezierska-Tys Stefania , Joniec Jolanta , Mocek-Płóciniak Agnieszka , Gałązka Anna , Bednarz Joanna , Furtak Karolina
Published: November 2021

Purpose

The use of glyphosate in agriculture raises a lot of controversy because research concerning its impact on the soil provides contradictory information. However, despite these negative opinions, glyphosate is still used in agricultural practice. Therefore, for a more complete assessment, the authors carried out research using traditional microbiological methods and a modern method of metabolic profile analysis in glyphosate-treated soil.

Methods

The study was carried out on the soil witch was sown with six cultivars of rapeseed. Seven days before harvest, the plants were sprayed with the herbicide. The analyses consisted in determining the number of selected groups of microorganisms, biochemical and enzymatic activity, and differentiation of the catabolic potential of soil microbial communities.

Results

The results showed significant changes in the analyzed parameters. Respiratory activity and ammonification processes were stimulated in the treatments with rapeseed cultivation treated with the herbicide. Changes in the enzymatic activity were generally positive. The EcoPlate assessment of microbial community catabolism showed that the highest activity was recorded in the soil sown with the cultivars Belinda, Tamarin, and Sw svinto. Concurrently, these soils were characterized by the highest correlations between rapeseed cultivar and metabolic activity.

Conclusion

Cultivation of specific plant varieties that reduce the negative effect of herbicides used in agriculture may be one of the methods to prevent soil degradation. In our research, Belinda turned out to be a cultivar, under the cultivation of which an increase in the activity of microorganisms was recorded most frequently compared to soil not sown with rapeseed.
Screening of grapevine red blotch virus in two European ampelographic collections
Authors: Reynard Jean-Sébastien , Brodard Justine , Dubuis Nathalie , Kellenberger Isabelle , Spilmont Anne-Sophie , Roquis David , Maliogka Varvara , Marchal Cécile , Dedet Sandrine , Gning Ophélie , Croll Daniel , Gindro Katia , Schumpp Olivier , Spring Jean-Laurent , Lacombe Thierry
Published: November 2021

Grapevine red blotch virus (GRBV) is a recently identified virus that infects grapevine and has a severe impact on the grape industry in North America. Since the first description of the virus 8 years ago, clear progress has been made regarding our understanding of the GRBV pathosystem. However, questions remain regarding the origin of this pathogen and its spread outside North America, especially in Europe. In this study, we present the results of a large-scale GRBV survey in two European repositories; we targeted Vitis spp. accessions with diverse geographical origins. Of 816 accessions from different origins (50 different countries around the world), six accessions were infected by GRBV, all of which originated from the United States. We investigated the DNA virome of 155 grapevine accessions from the Swiss grapevine collection using high-throughput sequencing. We observed that virome of the Swiss grapevine collection was composed of several RNA viruses. In contrast, we did not detect any DNA viruses in the 155 Swiss grapevine accessions. This finding suggests that the abundance of DNA viruses infecting grapevines in Switzerland is either very low or non-existent. Our results and the findings of studies published since 2008 show that GRBV most likely originated in North America and subsequently spread to other viticultural areas in the world via unintentional movement of infected cuttings. According to our data, the most plausible scenario for the origin of GRBV is that the virus evolved from non-Vitis vinifera hosts and underwent a host jump to Vitis vinifera after its introduction to North America in the 1600s.
Virulence of Icelandic Pyrenophora teres f. teres populations and resistance of Icelandic spring barley lines
Authors: Novakazi Fluturë , Göransson Magnus , Stefánsson Tryggvi Sturla , Hokka Marjo , Jalli Marja , Hallsson Jón Hallsteinn
Published: November 2021

The causal agent of the barley net blotch disease, Pyrenophora teres, is known for its high level of diversity due to sexual reproduction. Different pathotypes, defined by a virulence combination, even within the same fields are frequently found and virulence between locations can vary considerably. Evaluation of virulence patterns of a pathogen population is essential for breeding resistant cultivars suitable for specific locations. To identify virulence patterns in Icelandic Pyrenophora teres f. teres (Ptt) isolates, twenty single spore isolates of Ptt were collected from seven locations in Iceland and analysed with AFLP markers. Principle Coordinate Analysis (PCoA) revealed Icelandic Ptt isolates clustering away from reference isolates from Austria, Finland, Sweden, Switzerland, UK, and USA. Hierarchical clustering grouped the Icelandic isolates into three distinct groups. Furthermore, the virulence of these twenty isolates was tested on 16 barley differential lines and revealed high variation in their virulence. Twenty-one barley cultivars commonly used in Iceland showed high susceptibility towards inoculation with Icelandic Ptt isolates.
Enhanced Parkinson’s Disease Tremor Severity Classification by Combining Signal Processing with Resampling Techniques
Authors: AlMahadin Ghayth , Lotfi Ahmad , Carthy Marie Mc , Breedon Philip
Published: November 2021

Tremor is an indicative symptom of Parkinson’s disease (PD). Healthcare professionals have clinically evaluated the tremor as part of the Unified Parkinson’s disease rating scale (UPDRS) which is inaccurate, subjective and unreliable. In this study, a novel approach to enhance the tremor severity classification is proposed. The proposed approach is a combination of signal processing and resampling techniques; over-sampling, under-sampling and a hybrid combination. Resampling techniques are integrated with well-known classifiers, such as artificial neural network based on multi-layer perceptron (ANN-MLP) and random forest (RF). Advanced metrics are calculated to evaluate the proposed approaches such as area under the curve (AUC), geometric mean (Gmean) and index of balanced accuracy (IBA). The results show that over-sampling techniques performed better than other resampling techniques, also hybrid techniques performed better than under-sampling techniques. The proposed approach improved tremor severity classification significantly and show that the best approach to classify tremor severity is the combination of ANN-MLP with Borderline SMOTE which has obtained 93.81% overall accuracy, 96% Gmean, 91% IBA and 99% AUC. Besides, it is found that different resampling techniques performed differently with different classifiers.
Sustain GEOBIM—a New Method to Simulate Sustainable Development Scenarios for Urban Areas
Authors: Bernegger Heinz J. , Laube Patrick , Ochsner Pascal , Meslec Mihaela , Rahn Hanno , Junghardt Johann , Aurich Isabella , Ashworth Simon
Published: November 2021

In 2015, 193 member states of the United Nations (UN) signed the 2030 Agenda, entitled “Transforming Our World: The 2030 Agenda for Sustainable Development,”. The planned implementation by 2030, leaves only a decade to realize the 17 Sustainable Development Goals (SDG). Municipalities and cities constitute important stakeholders, who are obliged under SDG 11, to find ways to develop realistic solutions. Implementation and strategic planning require, among other things, new instruments to digitally model various sustainable development scenarios. Currently, however, it is still unclear what has to be modelled and how. What is clear is that sustainability and digitalization have to come together to deliver results. Several key challenges need to be overcome. First, is the heterogeneity of existing data and documents used in the built environment. Future solutions will depend on a combination of Building Information Modelling (BIM) and Geographic Information System (GIS). Second, is the merging of different existing data on an adequate level of abstraction which allows practical use of GIS and BIM data in a common model. Third, is the development of functioning, cost-effective workflows that will enable broad applications which adequately simulate specific sustainability aspects using spatial and temporal scenarios. This paper shows how these challenges can be systematically addressed in practice. It demonstrates which aspects of sustainability can be made visible and comprehensible for all stakeholders using only one single BIM- and GIS based data model. The proposed workflow could thus be considered as the basis for planning the next generation of smart and sustainable cities.
Family relationship quality during the COVID‐19 pandemic: The value of adolescent perceptions of change
Authors: Martin‐Storey Alexa , Dirks Melanie , Holfeld Brett , Dryburgh Nicole S.J. , Craig Wendy
Published: November 2021

Introduction

Adolescents typically spend decreasing amounts of time with family members, but the COVID‐19 pandemic changed this pattern for many youth. The objective of the current study was to better understand adolescents' perceived change in family relationship quality, and how these perceptions were related to psychosocial functioning during the COVID‐19 pandemic, accounting for more traditional measures of family relationship quality. Understanding how adolescents perceived change in relationship quality with family members during the pandemic offers novel insight into adolescents’ relationships with their families and psychosocial functioning during this period.

Method

A sample of Canadian adolescents (N = 605, ages 14 to 18, 53% girls), was employed to examine patterns of adolescents’ perceived change in relationship quality with parents and siblings since the start of the pandemic, accounting for relationship quality, pandemic‐related characteristics, and demographic variables.

Results

Four latent profiles were identified: youth who perceived (1) low change, (2) improvement only, (3) moderate instability and (4) high instability in relationship quality. Higher perceived instability was associated with poorer functioning, with youth who reported only improvement reporting the highest overall level of functioning.

Conclusions

Adolescent perceptions of change in relationship quality were heterogeneous, and contribute to psychosocial functioning over and above their general evaluations of relationship quality. In particular, youth who perceive considerable change in their relationships with siblings and parents may require additional support in response to the COVID‐19 pandemic.
Homological Theory of Representations
Authors: Krause Henning
Published: November 2021

Modern developments in representation theory rely heavily on homological methods. This book for advanced graduate students and researchers introduces these methods from their foundations up and discusses several landmark results that illustrate their power and beauty. Categorical foundations include abelian and derived categories, with an emphasis on localisation, spectra, and purity. The representation theoretic focus is on module categories of Artin algebras, with discussions of the representation theory of finite groups and finite quivers. Also covered are Gorenstein and quasi-hereditary algebras, including Schur algebras, which model polynomial representations of general linear groups, and the Morita theory of derived categories via tilting objects. The final part is devoted to a systematic introduction to the theory of purity for locally finitely presented categories, covering pure-injectives, definable subcategories, and Ziegler spectra. With its clear, detailed exposition of important topics in modern representation theory, many of which were unavailable in one volume until now, it deserves a place in every representation theorist's library.
Social policies, risks and vulnerabilities: A gender perspective for Mauritius
Authors: Tandrayen-Ragoobur Verena , Gokulsing Deepa , Irving Zoe
Published: November 2021

This article investigates into how gender-neutral social policies affect gender dynamics of labour market participation, family life and livelihood. Taylor-Gooby’s [“New risks and social change”, pp. 1–28, 2004] new social risks concept and Holmes and Jones’ [Rethinking Social Protection from a Gender Lens. ODI Briefing Paper, 2010] framework are used to probe into the deepening of existing gender inequalities in the Mauritian multicultural society. The article argues that the prevailing social interventions in Mauritius overlook new social risks that have stemmed from the island’s economic transformation from a monocrop to an innovation based economy. This structural change has caused women, in particular, to face new risks and vulnerabilities. To advance the argument, the article examines gender norms, lack of appropriate gender-sensitive labour market policies and gender-neutral social protection measures. A mixed methodology is used with both secondary and primary data collected via interviews with key stakeholders from public and non-governmental organisations. The findings reveal the need to connect gender-sensitive welfare policies to risks and vulnerabilities to promote greater gender inclusiveness.
When politicization meets ideology: the European Parliament and free trade agreements
Authors: Migliorati Marta , Vignoli Valerio
Published: November 2021

Since the Lisbon Treaty, the European Parliament (EP) has considerably increased its competencies in European Union (EU) trade policy. At the same time, a ‘new generation’ of free trade agreements (FTAs), including the Transatlantic Trade and Investment Partnership (TTIP) with the United States, Comprehensive Economic and Trade Agreement (CETA) with Canada, and the agreement with Japan, have been negotiated by the European Commission. Although existing literature has tackled the process of the EP's institutional self-empowerment in this policy area, there is no systematic research investigating the lines of conflict within the EP over FTAs. Through a newly collected dataset of all EP plenary debates between 2009 and 2019 on six relevant FTAs, we extract EP Members’ (MEPs) preferences by means of a manual textual analysis. We then test the explanatory power of the two traditional lines of cleavages within the EP over MEPs stated preferences: position on the left-right axis and support for EU integration. We find that both these dimensions fundamentally shape the conflict in the EP over FTAs. The impact of these two ideological cleavages is magnified in the context of politicized FTAs, namely the TTIP and CETA. Through these findings, the paper significantly contributes to the research on competition in the EP and, more broadly, to the understanding of EU trade policy and its emerging politicization dynamics.
LOCALIZED IMPLEMENTATION: ECONOMIC AND ENVIRONMENTAL IMPACT OF THE BELT AND ROAD INITIATIVE IN CHINA
Authors: Yin Haitao , Hu Yunyi , Tian Xu
Published: November 2021

China's overcapacities in manufacturing industries, including pollution-intensive industries, served as an important motivation of the Belt and Road Initiative (BRI). The popular Pollution Haven Hypothesis (PHH) therefore expects that the initiative will lead to the relocation of polluting industries from China to the recipients. Focusing on the implementation by local governments, we argue that actual outcomes of the BRI depend on the way local states and businesses respond to the BRI in accordance with their preferences. Through investigating industries’ actual responses to the BRI, we found that pollution-intensive industries have not relocated but rather expanded exports to the BRI countries. This has two implications: on the one hand, it alleviates the overcapacity issue in China and helps sustain the economic performance of the industry; on the other hand, it results in more pollution within Chinese borders and aggravates the environmental challenges facing the country.
A REPUTATION DEFICIT? THE MYTHS AND REALITY OF CHINESE INVESTMENT IN ZAMBIA
Authors: Shi Weiyi , Seim Brigitte
Published: November 2021

What drives public discontent about Chinese investment on the ground? This study probes the “ground truth” of public reaction in Zambia by documenting both the public perception and the actual impacts of Chinese investments. We find a “reputation deficit” for Chinese investment: Zambians are significantly less likely to support Chinese investment than investment from other countries. Combining results from an original household survey, interview records, and official statistics, we examine the drivers of this reputation deficit. Chinese firms are no worse at generating employment or adhering to labor and environmental standards than Western corporations operating in Zambia, according to official statistics as well as public opinion. However, Chinese firms possess a lower degree of localization, specifically in managers’ knowledge of local languages and the provision of culturally relevant benefits, and they are less likely to engage with the media. Our study highlights these previously overlooked causes of the reputation deficit.
ANCESTRY AND FAMILY IDENTITY IN SUETONIUS’ CAESARS
Authors: Garrett Phoebe
Published: November 2021

Suetonius’ Lives of the Caesars usually begin with a family tree. These family trees are often rhetorical, foreshadowing in the ancestors character traits that will be themes of the rest of the Life. This particular rhetorical strategy relies upon an older phenomenon of ‘family identity’—namely, the literary application of similar characteristics to people in the same family—such as the one that tells us that the Claudii are proud and the Domitii Ahenobarbi are ferocious. Gary Farney studied ‘family identity’ as a phenomenon of the Republic. There, it was the association of a family with a certain characteristic, a kind of ‘branding’. It would be perfectly obvious for Suetonius to use the family identities already in use for well-known families, but, as I show here, Suetonius’ selection of ancestors creates different family identities rather than simply using the traditional ones he would have found in other sources. In this study I concentrate on Nero and Tiberius. I focus on these two emperors because they are individuals where there is a known family identity in other sources and they also have the most detailed and elaborate ancestry sections in Suetonius’ Caesars. Family identity seems to be most interesting to Suetonius when it goes against expectations, and that is when Suetonius’ family trees are most elaborate.
Swayne's hartebeest in Ethiopia: population estimate, genetic variability and competition with livestock
Authors: Tamrat Misganaw , Atickem Anagaw , Flagstad Øystein , Fischer Martha , Roos Christian , Evangelista Paul , Bekele Afework , Stenseth Nils Chr , Zinner Dietmar
Published: November 2021

Swayne's hartebeest Alcelaphus buselaphus swaynei was once widely distributed in the Horn of Africa. By the early 20th century, however, it was extirpated across most of its range and is now limited to two relict populations in the Ethiopian Rift Valley and categorized as Endangered on the IUCN Red List. In this study, we estimated the size and genetic diversity of these two remaining populations, with a particular focus on competition with livestock. We used a total block count method for both Swayne's hartebeest and livestock population counts, and faecal samples for a population genetic analysis. We estimated the total population of Swayne's hartebeest to be 1,528, with 518 individuals in Senkele Swayne's Hartebeest Sanctuary and 1,010 individuals in Maze National Park. Livestock densities were 212 and 153 times those of Swayne's hartebeest in Senkele Swayne's Hartebeest Sanctuary and Maze National Park, respectively. Among 73 mitochondrial D-loop sequences (34 from Senkele Swayne's Hartebeest Sanctuary and 39 from Maze National Park), we found 22 haplotypes (Senkele 12, Maze 16, shared 6). Population genetic parameters suggest only weak sub-structuring between the two populations (FST = 0.164). Despite the positive population trends in both protected areas, the spatial overlap with livestock may lead to future population decline as a result of resource competition and disease transmission. We therefore recommend further translocation to other protected areas within the species’ former range.
The importance of social activity to risk of major depression in older adults
Authors: Ryu Euijung , Jenkins Gregory D. , Wang Yanshan , Olfson Mark , Talati Ardesheer , Lepow Lauren , Coombes Brandon J. , Charney Alexander W. , Glicksberg Benjamin S. , Mann J. John , Weissman Myrna M. , Wickramaratne Priya , Pathak Jyotishman , Biernacka Joanna M.
Published: November 2021

Background

Several social determinants of health (SDoH) have been associated with the onset of major depressive disorder (MDD). However, prior studies largely focused on individual SDoH and thus less is known about the relative importance (RI) of SDoH variables, especially in older adults. Given that risk factors for MDD may differ across the lifespan, we aimed to identify the SDoH that was most strongly related to newly diagnosed MDD in a cohort of older adults.

Methods

We used self-reported health-related survey data from 41 174 older adults (50–89 years, median age = 67 years) who participated in the Mayo Clinic Biobank, and linked ICD codes for MDD in the participants' electronic health records. Participants with a history of clinically documented or self-reported MDD prior to survey completion were excluded from analysis (N = 10 938, 27%). We used Cox proportional hazards models with a gradient boosting machine approach to quantify the RI of 30 pre-selected SDoH variables on the risk of future MDD diagnosis.

Results

Following biobank enrollment, 2073 older participants were diagnosed with MDD during the follow-up period (median duration = 6.7 years). The most influential SDoH was perceived level of social activity (RI = 0.17). Lower level of social activity was associated with a higher risk of MDD [hazard ratio = 2.27 (95% CI 2.00–2.50) for highest v. lowest level].

Conclusion

Across a range of SDoH variables, perceived level of social activity is most strongly related to MDD in older adults. Monitoring changes in the level of social activity may help identify older adults at an increased risk of MDD.
Antipsychotic medication for women with schizophrenia spectrum disorders
Authors: Brand Bodyl A. , Haveman Yudith R. A. , de Beer Franciska , de Boer Janna N. , Dazzan Paola , Sommer Iris E. C.
Published: November 2021

There are significant differences between men and women in the efficacy and tolerability of antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known about the pharmacokinetics and pharmacodynamics of antipsychotics in women with schizophrenia spectrum disorders (SSDs) and translate these insights into considerations for clinical practice. Slower drug absorption, metabolism and excretion in women all lead to higher plasma levels, which increase the risk for side-effects. Moreover, women reach higher dopamine receptor occupancy compared to men at similar serum levels, since oestrogens increase dopamine sensitivity. As current treatment guidelines are based on studies predominantly conducted in men, women are likely to be overmedicated by default. The risk of overmedicating generally increases when sex hormone levels are high (e.g. during ovulation and gestation), whereas higher doses may be required during low-hormonal phases (e.g. during menstruation and menopause). For premenopausal women, with the exceptions of quetiapine and lurasidone, doses of antipsychotics should be lower with largest adjustments required for olanzapine. Clinicians should be wary of side-effects that are particularly harmful in women, such as hyperprolactinaemia which can cause oestrogen deficiency and metabolic symptoms that may cause cardiovascular diseases. Given the protective effects of oestrogens on the course of SSD, oestrogen replacement therapy should be considered for postmenopausal patients, who are more vulnerable to side-effects and yet require higher dosages of most antipsychotics to reach similar efficacy. In conclusion, there is a need for tailored, female-specific prescription guidelines, which take into account adjustments required across different phases of life.
Socioemotional profiles of autism spectrum disorders, attention deficit hyperactivity disorder, and disinhibited and reactive attachment disorders: a symptom comparison and network approach
Authors: Coughlan Barry , Woolgar Matt , van IJzendoorn Marinus H. , Duschinsky Robbie
Published: November 2021

Children with autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD) and disinhibited and reactive attachment disorders (RAD/DAD) often experience socioemotional problems. Elucidating a clear picture of these profiles is essential. Strengths and Difficulties Questionnaires (SDQs) were analysed from cohort of children with ASD (n = 1430), ADHD (n = 1193), and RAD/DAD (n = 39). Kruskal–Wallis Tests and network analytic techniques were used to investigate symptom profiles. Children with ASD experienced more emotional problems, peer problems and fewer prosocial behaviours. Children with ADHD and RAD/DAD had higher levels of hyperactivity and conduct problems. Overall, ASD and ADHD networks were highly correlated (rs= 0.82), and we did not observe a statistically significant difference in terms of global Strength.
Intervention for promoting intake of fruits and vegetables in Brazilians: a randomised controlled trial
Authors: Mendonça Raquel de Deus , Mingoti Sueli Aparecida , Gazzinelli Bethony Maria Flávia , Martinez-Gonzalez Miguel Angel , Bes-Rastrollo Maira , Lopes Aline Cristine Souza
Published: November 2021

Objective:

To evaluate the effectiveness of a nutritional intervention to promote fruit and vegetable (FV) intake.

Design:

A randomised controlled community trial was conducted to evaluate the effectiveness of a 7-month nutritional intervention and to promote FV intake, separately and together. All participants attended physical exercise sessions. The intervention was based on the transtheoretical model and Paulo Freire’s pedagogy. The interventions included group educational sessions, motivational cards and informational materials. The primary outcome was a change in FV intake (g/d), and secondary outcomes included stages of change, self-efficacy, decisional balance and knowledge on FV. All data were collected face-to-face; and FV intake was assessed using a validated brief questionnaire.

Setting:

Health promotion services of Brazilian Primary Health Care.

Participants:

3414 users of Brazilian Primary Health Care (1931 in the control group and 1483 in the intervention group (IG)).

Results:

At baseline, the average daily FV intake was 370·4 g/d (95 % CI 364·2, 376·6). The increase in FV intake (23·4 g/d; 95 % CI 6·7, 40·0) and fruit intake (+17·3 g/d; 95 % CI 5·1, 29·4; P = 0·01) was greater in the IG among participants in the lowest baseline intake. Participants in the IG also showed progression in the stages of change (P < 0·001), increased self-efficacy (P < 0·001) and improved knowledge of FV crops (P < 0·001).

Conclusions:

The nutritional intervention was effective in increasing FV intake and fruits intake among individuals with a lower intake at baseline and in maintaining FV intake among those who reported consuming FV as recommended (400 g/d).
Factors associated with low knowledge about sexually transmitted infections in subnormal agglomerate, in the Brazilian Amazon
Authors: Ferreira Glenda Roberta Oliveira Naiff , de Oliveira Ingrid Saraiva , Freitas Wanne Letícia Santos , Lira Ana Luisa Brandão de Carvalho , Reis Renata Karina , Gir Elucir , Ramos Aline Maria Pereira Cruz , Gonçalves Lucia Hisako Takase , Botelho Eliã Pinheiro
Published: November 2021

Background:

Populations living in subnormal agglomerates in urban areas are more vulnerable to infections, including sexually transmitted infections (STIs). In these groups, inadequate knowledge about sexually transmitted infections can further increase the risk of contracting STIs.

Aim:

We investigated the factors associated with low knowledge about STIs in a peripheral population in the Brazilian Amazon.

Methods:

This cross-sectional study was conducted in Belém, in the Amazon region that has a high percentage of subnormal agglomerates in an urban area and a high incidence of STIs. Random sampling was adopted which resulted in a sample of 320 participants. To assess knowledge about STIs, the self-administered Sexually Transmitted Disease Knowledge Questionnaire was used. To assess aspects of vulnerability, a questionnaire was constructed which is linked to individual, social, and programmatic factors. The chi-square test, G test, and ordinal regression analyses were all performed.

Findings:

The sample of this study was composed of 320 participants. The mean age of the participants was 46.09 years. 37.5% (120), 50.6% (162), and 11.9% (38) showed low, medium, and high knowledge, respectively. Multiple analysis revealed that the factors associated with higher chance of having smaller knowledge about sexually transmitted infections were single/separated/divorced/widow(er) marital status (AOR: 1.80, CI: 1.15-2.84, P = 0.01); income equal to or less than one minimum wage (1.98, CI: 1.21-3.17, P = 0.00); equal to or over than 52 years old (AOR: 1.99, CI: 1.25-3.17, P = 0.00); lack of guidance by a health professional (AOR: 1.59, CI: 1.01-2.51, P = 0.04). Our results show that this community suffer from suboptimal levels of knowledge on STIs, which are linked to individual, social, and programmatic factors. Characterising the risk and vulnerabilities factors allows for carrying out appropriate interventions for populations living in subnormal agglomerates in urban area.
Tackling the DM Challenges with cDMN: A Tight Integration of DMN and Constraint Reasoning
Authors: VANDEVELDE SIMON , AERTS BRAM , VENNEKENS JOOST
Published: November 2021

Knowledge-based AI typically depends on a knowledge engineer to construct a formal model of domain knowledge – but what if domain experts could do this themselves? This paper describes an extension to the Decision Model and Notation (DMN) standard, called Constraint Decision Model and Notation (cDMN). DMN is a user-friendly, table-based notation for decision logic, which allows domain experts to model simple decision procedures without the help of IT staff. cDMN aims to enlarge the expressiveness of DMN in order to model more complex domain knowledge, while retaining DMNs goal of being understandable by domain experts. We test cDMN by solving the most complex challenges posted on the DM Community website. We compare our own cDMN solutions to the solutions that have been submitted to the website and find that our approach is competitive. Moreover, cDMN is able to solve more challenges than any other approach.
The Role of Self-Awareness and Problem-Solving Orientation for the Instrumentality of Goal-Related Means
Authors: Kreibich Antonia , Hennecke Marie , Brandstätter Veronika
Published: November 2021

Abstract. Successful goal striving hinges on the selection of instrumental means. The current research investigates individual differences in self-awareness as a predictor for means instrumentality. This effect should be mediated by the tendency of self-aware individuals to approach the process of goal pursuit in a way that is problem-solving-oriented. Four studies ( N1a = 123, N1b = 169, N2 = 353, N3 = 118) were conducted to explore the positive relation between self-awareness and means instrumentality via heightened levels of problem-solving orientation. Studies 1a and 1b found cross-sectional support for the relation between dispositional self-awareness and problem-solving orientation. Study 2 (preregistered) replicated this finding and provided experimental evidence for the hypothesized mediation model. Finally, Study 3 found longitudinal support that dispositional self-awareness and problem-solving orientation predict self-reported means instrumentality and, beyond this, participants’ objective exam grades. This research emphasizes the crucial role of individual differences in self-awareness for an important self-regulatory process, that is, the selection of instrumental means in personal goal pursuit.
Abandon Ship or Stay on Board?
Authors: Mallinas Stephanie R. , Plant E. Ashby , Maner Jon K.
Published: November 2021

Abstract. How do people respond when their group’s power is threatened? Four studies suggest that threats to group power lead people to adhere to and invest in their group. When a personally important group’s power was threatened, people psychologically adhered to the group (Studies 1a and 1b). This adherence occurred among people who were high (but not low) in group identification (Study 2). Adherence to the group was associated with behaviors aimed at promoting benefits to the group (Study 3). Findings suggest that people invest themselves in personally important groups when the group’s power is threatened. This occurs largely among people strongly identified with a group, suggesting that clinging to the group occurs especially when costs to leaving are high.
Constructing the Facets of Altruistic Behaviors (FAB)	Scale
Authors: Windmann Sabine , Binder Lucie , Schultze Martin
Published: November 2021

Abstract. Behavior is effectively altruistic to the degree that it is costly for the actor while benefiting others. In a series of preregistered studies, we constructed a 15-item self-report scale assessing three different facets of altruistic behavioral traits: help-giving, moral courage, and peer punishment. Item selection was performed with the help of Ant Colony Optimization (ACO) procedures as implemented in the stuart package for R. Confirmatory factor analysis of the three-factor measurement model showed excellent fit, outperforming classical item selection procedures. The scale was structure-validated in a second sample using a multiple group model that showed full measurement and structural invariance. A pilot study shows correlations of the subscales with economic game decisions. We discuss the scale structure and potential applications.
Building Consensus for Ambitious Climate Action Through the World Climate Simulation
Authors: Rooney‐Varga Juliette N. , Hensel Margaret , McCarthy Carolyn , McNeal Karen , Norfles Nicole , Rath Kenneth , Schnell Audrey H. , Sterman John D.
Published: November 2021

Sociopolitical values are an important driver of climate change beliefs, attitudes, and policy preferences. People with “individualist‐hierarchical” values favor individual freedom, competition, and clearly defined social hierarchies, while “communitarian‐egalitarians” value interdependence and equality across gender, age, heritage, and ethnicity. In the US, individualist‐hierarchs generally perceive less risk from climate change and express lower support for actions to mitigate it than communitarian‐egalitarians. Exposure to scientific information does little to change these views. Here, we ask if a widely used experiential simulation, World Climate, can help overcome these barriers. World Climate combines an engaging role‐play with an interactive computer model of the climate system. We examine pre‐ and post‐World Climate survey responses from 2,080 participants in the US and use a general linear mixed model approach to analyze interactions among participants' sociopolitical values and gains in climate change knowledge, affect, and intent to take action. As expected, prior to the simulation, participants holding individualist‐hierarchical values had lower levels of climate change knowledge, felt less urgency, and expressed lower intent to act than those holding communitarian‐egalitarian values. However, individualist‐hierarchs made significantly larger gains across all constructs, particularly urgency, than communitarian‐egalitarians. Participants' sociopolitical values also shifted: those with individualistic‐hierarchical values before the simulation showed a substantial, statistically significant shift toward a communitarian‐egalitarian worldview. Simulation‐based experiences like World Climate may help reduce polarization and build consensus towards science‐based climate action.
A Hybrid Mechanism for Enhanced Core‐Mantle Boundary Chemical Interaction
Authors: Lim Kang Wei , Bonati Irene , Hernlund John W.
Published: November 2021

Detection of chemical signatures from the core‐mantle boundary (CMB) could provide an unprecedented glimpse into our planet's deep interior and ancient past. Several isotopic and elemental anomalies in ocean island basalts (OIBs) have been proposed as core tracers. However, the process(es) by which particular chemical signatures from the core are conveyed into the mantle remain uncertain. Here, we propose a hybrid mechanism that results from a collaborative feedback between dynamic topography, porous infiltration of liquid metal into submerged rock, gravitational collapse of weakened metal‐silicate mush, and draw‐down of additional rocks from above in the induced small‐scale mantle circulation. Using a mantle convection model coupled to gravitational spreading of a thin layer, we show that induced mantle circulation due to the gravitational collapse of the layer becomes comparable to buoyancy‐driven mantle flow when the viscosity of the mushy layer is reduced to values ∼105 times smaller than the overlying mantle.
Double Intertropical Convergence Zones in Coupled Ocean‐Atmosphere Models: Progress in CMIP6
Authors: Si Wei , Liu Hailong , Zhang Xiaoxiao , Zhang Minghua
Published: November 2021

Reducing the double Intertropical Convergence Zone (ITCZ) bias has been the subject of intensive research in the climate modeling community. Recent studies have shown small to little progress in the ensemble of Coupled Model Intercomparison Project Phase 6 (CMIP6) models compared to Phase 3 (CMIP3) and Phase 5 (CMIP5) models in simulating the ITCZ. This study distinguishes the performances of the ensemble of CMIP models and the sub‐ensemble of top five models in reference to the double ITCZ bias by using the spatial correlation as the metric. We show that while there was little progress in the whole CMIP6 ensemble, there is progress in the top five models from CMIP5 to CMIP6. These models have largely eliminated the bias. This improvement is masked in the whole ensemble by the larger inter‐model spread. Results point to promising directions to which coupled models are heading to eradicate the chronic double ITCZ bias.