bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical Study of the Impact of Pore Size in TiO₂ Aerogels on Photocatalytic Formaldehyde Decomposition
Authors: Xiang Junhui , Sun Fenglei , Yu Xianbo
Published: May 2024

Formaldehyde (HCHO), an indoor volatile organic compound, is seriously harmful to human health. Therefore, green and effective decomposition of HCHO is essential. TiO2 has been employed for the degradation of HCHO via photocatalytic generation of reactive oxygen species (ROS) (O2-, ·OH), yet the low specific surface area of crystalline TiO2 depressed the catalytic performance. Herein, we prepared TiO2 aerogels with high specific surface area and high porosity by sol-gel method, and added PVA to introduce flexible molecular chains for pore size regulation. The photocatalytic performance test verifies that the pore size of TiO2 aerogel is one of the important factors for HCHO decomposition. Notably, through the establishment of theoretical model and calculation, we validated that the efficiency of HCHO decomposition is related to the oxygen pressure in the pores of TiO2 aerogel, and the oxygen pressure is inversely proportional to the pore size. Accordingly, the optimal pore size of TiO2 aerogel for the photocatalytic HCHO decomposition is 2 nm~10 nm. This study provides a theoretical idea for TiO2 aerogels in the decomposition reaction of HCHO, which is expected to inspire more breakthroughs in the study of TiO2 aerogels for green chemistry.
Evidence of Warm Welcome From the Cymodocea nodosa (Tracheophyta, Alismatales) Meadow in the Seas of Taranto (Southern Italy, Mediterranean Sea)
Authors: Denti Giuseppe , Rubino Fernando , Cecere Ester , Petrocelli Antonella
Published: May 2024

The collection of photo shoots during the systematic monitoring activities is useful to witness the ecological role of marine phanerogams as hosts for a rich variety of organisms in coastal and transitional waters. Cymodocea nodosa is present in the Taranto seas. In the Mar Piccolo, it reached high covers in short times, up to 100%, due to the bettering of the environmental conditions. The most recent observations showed that it offers welcoming towards several vertebrates and invertebrates, native and non-indigenous, as well as to micro and macroalgae. The NPPR funded activities will make these observations more robust and structural.
Pengembangan Media Self-Help Book Compassionate Mind untuk Mengurangi Tingkat Kritik Diri pada Mahasiswa
Authors: Berlianawati Hayadni
Published: May 2024

Penelitian ini bertujuan untuk mengembangkan sebuah buku bantuan diri sebagai referensi dalam mengurangi tingkat kritik diri pada mahasiswa. Penelitian ini menggunakan metode Penelitian berbasis Desain atau Design Based Research (DBR) yang dikembangkan oleh McKenney & Reeves. Tahapan dalam penelitian ini meliputi, analisis dan eksplorasi, desain dan konstruksi, serta evaluasi dan refleksi. Pada tahap analisis, peneliti melakukan studi pendahuluan pada 329 mahasiswa Universitas Negeri Jakarta yang meliputi Fakultas Bahasa dan Seni, Fakultas Ekonomi, Fakultas Ilmu Pendidikan, Fakultas Ilmu Olahraga, Fakultas Ilmu Sosial, Fakultas Matematika dan Ilmu Pengetahuan Alam, Fakultas Pendidikan Psikologi, dan Fakultas Teknik. Hasil rata-rata kritik diri yaitu, sebesar 38. Selanjutnya pada tahap evaluasi, produk divalidasi oleh dua validator ahli yaitu, validator ahli media dan ahli materi. Penelitian ini menghasilkan sebuah buku bantuan diri yang berjudul “Berdamai dengan Jejak Kritik Diri”. Hasil persentase kelayakan buku dari masing-masing validator yaitu, validator ahli media menilai sebesar 75% (Layak) dan validator ahli materi menilai sebesar 95% (Sangat Layak). Kesimpulan dari penelitian ini yaitu, buku bantuan diri ini dapat dikategorikan Sangat Layak dengan rata-rata persentase sebesar 85%. Diharapkan buku bantuan diri untuk mengurangi tingkat kritik diri dapat diujicoba sehingga semakin efektif saat digunakan.
Gambaran Self-Compassion Peserta Didik Sosial Ekonomi Kelas Bawah Pada Jenjang Sma Negeri Se-Kota Bekasi
Authors: Azillah Mutiara , Fitri Susi
Published: May 2024

Individu sebagai makhluk sosial tentu tidak bisa dihindarkan dari yang namanya interaksi sosial di masyarakat. Adanya interaksi sosial ini akan mempengaruhi pembentukan sebuah kelompok. Kelas sosial telah hadir di hampir setiap masyarakat dan telah menjadi topic sentral dalam ilmu sosial selama berabad-abad. Penelitian ini memiliki tujuan untuk mengetahui bagaimana self-compassion yang dimiliki oleh peserta didik dengan kelas sosial bawah pada jenjang SMA Negeri se-Kota Bekasi. Penelitian ini menggunakan metode kuantitatif yang bersifat deskriptif, bertujuan untuk melihat gambaran self-compassion pada peserta didik di Kota Bekasi. Hasil penelitian diperoleh kategorisasi data self-compassion menunjukkan bahwa mayoritas siswa dengan sosial ekonomi kelas bawah memiliki self compassion pada taraf yang tinggi dengan persentase sebesar 65,1% atau 256 siswa dari total secara keseluruhan responden. Hal ini menggambarkan siswa mampu menerima ketidaksesuaian yang terjadi pada dirinya dan dihadapi dengan welas asih yang baik melainkan menghindar dan terputus dari kondisi tersebut. Ketika dihadapi pencarian solusi saat terjadinya suatu masalah yang menimpa, indivisu mampu menghindari pemikiran negatif. Serta tidak melebih-lebihkan suatu hal yang akan membuat individu tenggelam dalam masalahnya. Kecenderungan ini didasarkan pada beberapa kondisi di mana siswa perempuan dilaporkan lebih kritis terhadap diri sendiri daripada siswa laki-laki, dan siswa perempuan berpikir lebih banyak daripada siswa laki-laki tentang kejadian negatif di masa lalu, daripada menghadapinya. Secara rinci, mindfulness siswa laki-laki memiliki skor 16,28 dan siswa perempuan memiliki skor lebih rendah yaitu 16,24 keduanya berada dalam kategori tinggi.
Hubungan Motivasi Belajar dan Lingkungan Belajar dengan Kemandirian Belajar Peserta Didik SMK Negeri di DKI Jakarta
Authors: Nadya Putri Permatasari  , Herdi
Published: May 2024

Penelitian ini bertujuan untuk mengetahui hubungan motivasi belajar dan lingkungan belajar dengan kemandirian belajar peserta didik SMK Negeri di DKI Jakarta. Penelitian ini adalah penelitian kuantitatif dengan metode korelasional. Sampel penelitian berjumlah 385 peserta didik SMK Negeri di DKI Jakarta dengan teknik insidental sampling. Metode analisis data menggunakan analisis deskriptif dan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa motivasi belajar dengan kemandirian belajar memiliki hubungan yang positif dengan nilai koefisien korelasi sebesar 0,633, kemudian lingkungan belajar dengan kemandirian belajar juga memiliki hubungan yang positif dengan nilai koefisien korelasi sebesar 0,607. Hasil tersebut membuktikan bahwa motivasi belajar dan lingkungan belajar adalah faktor yang dapat mempengaruhi kemandirian belajar peserta didik.
Tourism Activities in the Context of Ecological Footprint: Panel Data Analysis For Mediterranean Countries
Authors: Turan Koyuncu Fatma
Published: May 2024

Tourism is seen as one of the important sources of economic growth in developing countries. It makes positive contributions to the country's economy, with national income, foreign currency inflow and employment created. While the basis of investments in the tourism sector is primarily to achieve economic gains, today is the sustainable tourism concept emerged and the effects of tourism on the environment have come to the fore. Sustainability in tourism emerges as a new tourism approach that takes environmental damage into consideration. The aim of this study is to examine the relationship between tourism activities and ecological footprint in countries bordering the Mediterranean, using annual data for the period 2001-2021. In the analysis; Generalized Moment Method (GMM), system GMM, constant effects model and random effects models were used. The results of the analysis showed that tourism activities have a significant and positive impact on the ecological footprint of countries bordering the Mediterranean. The findings obtained from the study confirm the expectations that tourism activities increase the ecological footprint by causing environmental degradation.
Me and My AI Bot: Exploring the 'AIholic' Phenomenon and University Students' Dependency on Generative AI Chatbots - Is This the New Academic Addiction?
Authors: Salah Mohammed , Abdelfattah Fadi , Alhalbusi Hussam , Mukhaini Muna Al
Published: May 2024

Amidst the buzz of technological advancement in education, our study unveils a more disconcerting narrative surrounding student chatbot interactions. Our investigation has found that students, primarily driven by intrinsic motivations like competence and relatedness, increasingly lean on chatbots. This dependence is not just a preference but borders on an alarming reliance, magnified exponentially by their individual risk perceptions. While celebrating AI's rapid integration in education is tempting, our results raise urgent red flags. Many hypotheses were supported, pointing toward a potential over-dependence on chatbots. Nevertheless, the unpredictable outcomes were most revealing, exposing the unpredictable terrain of AI's role in education. It is no longer a matter of if but how deep the rabbit hole of dependency goes. As we stand on the cusp of an educational revolution, caution is urgently needed. Before we wholly embrace chatbots as primary educators, it is imperative to understand the repercussions of replacing human touch with AI interactions. This study serves as a stark wake-up call, urging stakeholders to reconsider the unchecked integration of chatbots in learning environments. The future of education may very well be digital, but at what cost to human connection and autonomy?
Resistance phenotypes and molecular characteristics of Staphylococcus aureus associated with pleuritis in patients at “Hôpital du Mali” teaching hospital
Authors: Kalambry Aimé Césaire , Potindji Tchamou Malraux Fleury , Guindo Ibrehima , Kassogue Ambara , Kambire Dinanibè , Dramé Boubacar Sidiki Ibrahim , Yéna Sadio , Doumbia Seydou , Diakité Mahamadou
Published: May 2024

Background
Staphylococcus aureus (S. aureus) is one of the pathogens strongly implicated in hospital infections. Data on the resistance and molecular characteristics of this bacterium are rare in Mali.
Objective
This study aimed to evaluate the antibiotic resistance patterns, virulence factors of S. aureus isolates from pleural fluid infections in hospitalized patients.
Methods
Pleural effusion samples were obtained by thoracentesis for bacteriological examination from October 2021 to December 2022 at the “Hôpital du Mali” teaching hospital. Comorbidities such as HIV/AIDS and diabetes were assessed. Standard microbiological procedures were used for bacterial identification. The disk diffusion method was used to identify methicillin-resistant S. aureus. The PCR amplification method was used to detect the following genes: lukE/D, sek, bsa, sel, and sep.
Results
This study analyzed 6096 samples from inpatients and found a pooled frequency of bacterial pleuritis of 526 (8.6%) in thoracic surgery and pediatric wards. S. aureus was isolated in 52 (9.88%) cases, of which 39 (75%) isolates were MRSA. There was no significant difference between the sexes (p = 1.00). The median age of the patients was 30 years. All S. aureus isolates showed resistance to penicillin-G. The leucocidin lukE/D toxin was detected in 7.7% of thoracic surgery patients, but sek, bsa, sel, and sep toxins were not found.
Conclusion
In this study, we found a high frequency of S. aureus (and MRSA) in pleurisy patients at the “Hôpital du Mali”. Only the leukocidin lukE/D was found. The empirical treatment protocol for pleurisy may need revision. Clindamycin, linezolid, teicoplanin, daptomycin, fosfomycin, vancomycin, moxifloxacin and fusidic acid were the most active antibiotics on our isolates in this study. Infection prevention measures, active surveillance, and effective therapeutic options are recommended.
WITHDRAWN: Effects of enzyme preparation and straw expansion treatment on sorghum micro-storage performance and microbial community
Authors: Sun Yuxin , Liu Mingjian , Bai Baochao , Sheng Panjie , An Jiangbo , Bao Ruiying , Yuan Zitong , Liu Tingyu , Shi Kai
Published: May 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Research and application of ROM based on Res-PINNs neural network in fluid system
Authors: Liu Yuhao , Hou Junjie , Wei Ping , Jin Jie , Zhang Renjie
Published: May 2024

The reduced-order-model(ROM) method provides a strong support for the rapid iteration and simulation verification of supporting fluid system design. This study focuses on the problems of gradient disappearance or explosion and incomplete learning of flow field characteristics in the training process of PINN ROM. Based on PINN model, an innovative ROM Res-PINNs is proposed. By embedding ResNet module into PINN neural network structure, it strives to improve the training stability of the model while retaining physical knowledge. In addition, parallel network structure is added to the model to improve its perception and learning ability of flow field state.At last, in order to verify the validity of the proposed model, two classical fluid problems, the flow around a cylinder and Vortex-Induced Vibration(VIV), are selected to compare and verify the proposed Res-PINNs model. The results show that Res-PINNs can reconstruct the flow field state more accurately, effectively overcome the problems of gradient disappearance or explosion and poor learning ability of PINN model during training, and provide a new solution for the application of deep learning order reduction method in aerospace system modeling and simulation.
'Roly-poly toy' motion during pollen exudation promotes rapid pollen adhesion in rice
Authors: Wada Hiroshi , Hatakeyama Yuto , Erra-Balsells Rosa , Muneta Takumi , Nonami Hiroshi , Ueda Hikari , Yamaga-Hatakeyama Yoko , Miyashita Naoya , Araki Takuya
Published: May 2024

Angiosperms reproduce throughout pollination, at which pollen grains move from anthers to stigma. After pollen capture, pollen hydration occurs throughout newly formed pollen foot (pollen adhesion) prior to germination1, whereas few reported in grass that an unusual phenomenon, called picolitre ‘pollen exudation’, occurs shortly after pollen capture2-5. However, the precise role(s) including its chemical composition are unknown. Here we show the exact dynamics of captured pollen grains during pollen exudation in rice. We found that the exudates originated from the grains ran down toward the receptive part to help the grains to self-position, causing ‘roly-poly toy’-like rocking motion to lead pollen adhesion. Furthermore, single-cell metabolomics6 suggests that high content of sugars, fatty acids, and redox-related metabolites site-specifically determined in the exudates likely participate in osmotic and molecular signaling in stigmatic apoplast, increasing the fluid viscosity. Altering the center of gravity in an object causes a rocking motion, and thus the observed pollen behavior suggests possible within-grain organelle rearrangements attributed to the metabolic changes induced at pollen capture. Therefore, we anticipate that pollen exudation plays a crucial role on the optimal pollen adhesion that enables rapid pollination in rice. This study also illustrates significance of the event in grass family.
VGF and VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through C3a receptor
Authors: Koh Jung-Min , Moon Sung Ah , Kim Jin-Man , Lee Young-Sun , Cho Han Jin , Choi Young Jin , Yoon Jong Hyuk , Kim Dayea , Che Xiangguo , Jin Xian , Baek In-Jeoung , Lee Seung Hun , Choi Je-Yong
Published: May 2024

New therapeutic targets, especially those that stimulate bone formation in cortical bone, are needed to overcome the limitations of current anti-osteoporotic drugs. We previously demonstrated that factors secreted from megakaryocytes (MK) promote bone formation. In this study, we conducted a proteomic analysis to identify a novel bone-forming factor from MK secretions. We revealed that Vgf, a nerve growth factor-responsive gene, and its derived active peptide AQEE30 in MK-conditioned media, played an important role in osteoblast proliferation and in vitro bone formation. In both Vgf-deficient male and female mice, cortical bone mass was significantly decreased due to reduced osteoblast number and bone formation activity. AQEE30 stimulated intracellular cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) activity in osteoblasts, whereas an adenylyl cyclase inhibitor blocked the AQEE30-stimulated osteoblast proliferation and in vitro bone formation. Complement C3a receptor-1 (C3AR1) were expressed and interacted with AQEE30 in osteoblasts, and C3AR1 inhibitions blocked all AQEE30-induced changes, including stimulated proliferation, bone formation, and cAMP production, in osteoblasts. Injecting a mini-PEGylated AQEE30 into calvaria increased the number of osteocalcin-positive cells and new bone formation. In conclusion, this study reveals a novel role of VGF in bone formation, particularly in cortical bone, and shows that AQEE30, a VGF-derived peptide, mediates this role by activating cAMP-PKA signalling via the C3AR1 receptor in osteoblasts.
Inhibition of discharge rates of neurons via electroacupuncture at Shenshu (BL23), Huantiao (GB30) , Weizhong (BL40) and Yanglingquan (GB34) to alleviate inflammation-induced discogenic sciatica
Authors: Li Lijuan , Dai Hongbin , Wang Baoshan , Tang Hailing
Published: May 2024

Sciatica is closely related to the disease symptoms of lumbar disc herniation. Previous studies exhibited that electroacupuncture (EA) can effectively relieve chronic low back pain and sciatica. However, the mechanism underlying the analgesic effects of EA on discogenic sciatica is still largely confusing. In this study, model rats of discogenic sciatica were established to avoid causing direct compression. Male SD rats were randomly divided into sham operation group (FM), model group (M), electroacupuncture group (EA), electroacupuncture sham point group (NA) and sham operation electroacupuncture group (SEA). EA with low-frequency electronic pulse was adjusted to continuous wave (2Hz, 1mA) mode, and applied to the specified fixed acupuncture points (BL23, GB30, BL40, GB34) for 20 min on odd days for 4 weeks. After EA treatment for 4 weeks, the sensory neurons in the dorsal horn of the spinal cord in FM and SEA groups remained silent throughout the recording time, while the firing rates of neurons in M and NA groups stayed active at 20 ~ 30 sparks/10s. The EA group had a significantly lower firing rate during the EA intervention process compared to the M and NA groups. EA intervention can effectively reverse the abnormal excitability of sensory neurons in the dorsal horn of the spinal cord, improve the plantar mechanical pain threshold and inflammatory factors depending on the accurate selection of acupuncture points in discogenic sciatica rat models.
Semantic Sentiment based LDA for Detecting Sentiments of Short Texts
Authors: Tajbakhsh Mir Saman , Solouk Vahid , Ranjbar Vahid , Salehi Mostafa
Published: May 2024

Textual contents are very powerful sources of information about events. Twitter, as a microblogging social network provides such a platform for users in order to publish their thoughts about a special happening. However, deliberation on this social network indicates that words are majorly used in sentiments different that their original sounds. For instance, the word Damn or Hell despite their negative sounds are widely used to express positive feelings about the subject. In addition, there is a wide variety of words which are used in so-called microblogging form, rather than their original format which hinders the use of current sentimental databases to return the meaning. Lack of such database, makes the process of acquiring information with difficulties. The current paper introduces a novel topic modeling method for finding the sentiments in short texts using previous knowledge of trusted sources for sentiments. As the trusted source of sentiments, we utilized emojis that were extracted from a database of nearly 8 million tweets. The included in the process of sentiment analysis in a process of 9 stages. Further, the acquired word in each stage were appended to the next stage in form of a back propagation algorithm in order to incorporate the proposed method over the large sets of short texts which can be applied in real tweets. Thus, a sentimental database for heterogeneous words distinguishing sentimentally positive and negative words, and including hidden words named as Golden List were created. A validation test over the words acquired in each step, shows a sign of higher occurrence rate and sentimental closeness in negative top words rather than in positive top words in terms of Jaccard similarity. Moreover, the comparisons of the created dataset with two databases with the maximum of 20% word hit, indicates similarity rate of above 55% for both positive and negative top words.
Molecular, Cytological and Morphological Studies on Jassid Resistance in Cotton (Gossypium Hirsutum L.) Based on Hairiness Trait
Authors: S SUBHASHINI , K KEERTHIVARMAN , Rajeswari S. , N PREMALATHA , T KALAIMAGAL , M MUTHUSWAMI , P JEYAKUMAR
Published: May 2024

The parents MCU 5, CO 14, CO 17, TCH 1828, KC 2, KC 3, GISV 323, GTHV 15–34 and RHC 1409 of upland cotton were used for the present study. They were obtained from the Tamilnadu Agricultural University, Department of cotton, Coimbatore. Among the 27 primers used only JESPR 154 primer showed amplified fragment at 150 bp which validates the corresponding parents with hairiness trait conferring resistance to Jassid. The hairy nature of trichome density was observed among the resistant genotypes (KC 3, GTHV 15–34, GISV 323 and RHC 1409). Hairiness confers resistance to jassids was evidence from the results and discussion which would confer breeders develop varieties with high resistance genotypes thereby reducing the jassid infestation. The trichomes were found to confer resistance to sucking pests. This henceforth reduce the pesticide consumption in cotton plants thereby paving the way for a safety environment for ecological species without harming them. Pesticide usage would be lowered with the use of tolerant genotypes. It also paves way for the improvement of future integrated pest management (IPM) programme.
Designing an effective educational toy: incorporating design-thinking and user-centered design in the design classroom
Authors: Houston Natalie , Manrique Ferney
Published: May 2024

The “designing an effective educational toy” is a research project that emerged from a teaching and learning course designed to facilitate creative engagement both inside and outside the classroom at Wenzhou-Kean University in China. This research study examines the incorporation of design thinking and user-centered design concepts in the development of an educational toy by graphic design students. Utilizingthe ‘Double Diamond Model of Design’, thisresearch methodically progresses through the stages of observation, generation, prototyping, and testing to create a 3D letter-building kit with the goal of improving children's educational experiences. The approach prioritizes the integration of ideas through iterative design, taking safety into account, involving users, and focusing on instructional value. The key findings emphasize the effective implementation of design principles in developing a product that not only fulfills safety and educational requirements but also provides novel learning experiences. The essay continues by recommending the wider implementation of these concepts in the creation of educational toys to encourage improved learning outcomes and the development of skills in children.
Unlocking the Grain Quality Enigma: A KASP-Driven Voyage Through Bread Wheat's Quantitative Trait Nucleotides Under Heat Adversity
Authors: Bashir Latief , Budhlakoti Neeraj , Pradhan Anjan Kumar , Sharma Divya , Jain Antil , Rehman Saman Saim , Kondal Vishal , Jacob Sherry R , Bhardwaj Rakesh , Gaikwad Kiran , Mishra Dwijesh Chandra , Pandey Abhishek , Kaur Satinder , Bhati Pradeep Kumar , Singh Rakesh , Singh Gyanendra Pratap , Kumar Sundeep
Published: May 2024

Heat stress is a critical factor affecting global wheat production and productivity. In this study, out of 500 studied accessions a diverse panel of 126 wheat genotypes grown under twelve distinct environmental conditions was analyzed. Using 35K single-nucleotide polymorphism (SNP) genotyping assays and trait data on five biochemical parameters, including grain protein content (GPC), grain amylose content (GAC), grain total soluble sugars (TSS), grain iron (Fe), and zinc (Zn) content, six multi-locus GWAS models were employed for association analysis. This revealed 67 significantly associated QTNs linked to grain quality parameters, explaining phenotypic variations ranging from 3–44% under heat stress conditions. By considering the results in consensus to at least three GWAS models and three locations, the final QTNs were reduced to 17, with 14 being novel findings. Notably, two novel markers, AX-94461119 (chromosome 6A) and AX-95220192 (chromosome 7D), associated with grain iron and zinc, respectively, were validated through KASP approach. Candidate genes, such as chaperonin Cpn60/GroEL/TCP-1 family, P-loop containing nucleoside triphosphate hydrolases (NTPases), Bowman-Birk type proteinase inhibitor (BBI), and NPSN13 protein, were identified from the associated genomic regions, which could be potentially targeted for improving quality traits and heat tolerance in wheat.
Rapid degradation of thermosetting ester epoxies and monomer recovery methods
Authors: Hu Xinyue , Ma Hanbing , Zhou Baineng , Deng Yinjie
Published: May 2024

The degradation and recycling of waste epoxy resins is an urgent environmental problem, encouraging the use of degradable thermosetting epoxies. In this study, a high-performance thermosetting epoxy resin material that can be easily degraded and recycled was prepared using a low-viscosity and high-activity epoxy monomer, tetrahydrophthalic acid diglycidyl ester. Owing to the breakable ester bond in this epoxy monomer, the thermosetting three-dimensional epoxy cross-linked structure can be rapidly degraded using ethylene glycol at atmospheric pressure. After further depolymerization of the epoxy resin/glycol solution with NaOH, sodium cyclohexene-2-carboxylate was obtained. The sodium salt was acidified, epoxidized, and then re-prepared to obtain the epoxy monomer diglycidyl tetrahydrophthalate. The recycled epoxy monomer possesses the same thermal and mechanical properties as the original epoxy monomer, thus realizing the economic and environmentally friendly degradation and recycling of the thermosetting epoxy resin under mild conditions.
Toll-like receptor 3 orchestrates a conserved mechanism of heart regeneration
Authors: Fiegl Manuel , Röhrs Bernhard , Hau Dominik , Mair Sophia , Niederwanger Philipp , Regele Dominik , Merotto Lorenzo , Töchterle Sonja , Engler Clemens , Graber Michael , Kirchmair Elke , Niedrist Veronika , Muller Lynn , Pölzl Leo , Hirsch Jakob , Nägele Felix , Happacher Isidor , Oberegger Simon , Bonaros Nikolaos , Grimm Michael , Tancevski Ivan , Finotello Francesca , Meyer Dirk , Holfeld Johannes , Gollmann-Tepeköylü Can
Published: May 2024

The human’s heart responds to tissue damage with persistent fibrotic scarring. Unlike humans, zebrafish exhibit the ability to repair cardiac injury and re-grow heart tissue throughout life. Here, we provide novel evidence for toll-like receptor 3 (tlr3) driving cardiac regeneration in zebrafish. Upon cardiac injury, survival is decreased in tlr3-/- fish as compared to wildtype controls. Tlr3-/- zebrafish fail to recruit innate immune cells to the injured ventricle, resulting in impaired DNA repair and transcriptional reprogramming of cardiomyocytes. Mechanistically, we uncover an evolutionary conserved mechanism of tlr3 activation in fibroblasts promoting monocyte migration towards an injured ventricular area. Our data reveal tlr3 as a novel therapeutic target to promote cardiac regeneration.
Selective Noradrenergic Activation of BDNF Translation by Mirtazapine
Authors: Ciraci Viviana , Santoni Letizia , Tongiorgi Enrico
Published: May 2024

Antidepressants are known for their neurotrophic effects, particularly through the regulation of brain-derived neurotrophic factor (BDNF) expression. Mirtazapine, a tetracyclic noradrenergic and specific serotonergic antidepressant (NaSSA) has been observed to upregulate BDNF, though its underlying mechanism remains unclear. In this study, we used the human neuroblastoma SH-SY5Y cell line to investigate whether mirtazapine could enhance BDNF translation by modulating serotonin and/or norepinephrine and their receptors. A 1-hour stimulation with 1 or 10 µM mirtazapine led to downregulation of serotonergic receptors 5HT1A, while increasing ADRA2A and ADRB2 receptors. Mirtazapine at 10 µM upregulated endogenous BDNF after 3h, but not 1h stimulation. To investigate the translation of major BDNF transcripts, we used chimeric BDNF-luciferase constructs with the untranslated 5'UTR exons I, IIc, IV, or VI, and the long version of the 3'UTR. Luciferase assays and Western blotting revealed that mirtazapine selectively enhanced exon-IIc-BDNF-long3'UTR-Luciferase translation. This increase was associated with norepinephrine release and was inhibited by blocking ADRA2A or ADRB2 adrenoceptors for the exon-IIc-BDNF-long3'UTR-Luciferase, and ADR2B for endogenous BDNF. These findings provide a new perspective on the critical role of the noradrenergic system in mediating mirtazapine’s effects on BDNF translation. We propose a novel mechanism of action in which mirtazapine promotes norepinephrine release and noradrenergic responses by upregulating ADRA2A and ADRB2 while downregulating serotonergic receptors.
The Significance of Community Pharmacies' Services Beyond Dispensing Separation: A Rapid Scoping Review
Authors: Hamzah Mohd Shah Rezan
Published: May 2024

Background: The debate on dispensing separation (DS) for community pharmacists in Malaysia has been going on for decades, with numerous arguments arising. Given the evolving role of community pharmacists from medication dispensing to patient care services nowadays, community-based pharmacist practitioners in community-based settings are now capable of developing innovative community pharmacy practices and providing patient care services as a step towards the absence of DS.
Objective: The objectives of this rapid scoping review are to provide an overview of the alternative initiatives that can be pursued by community pharmacies beyond DS by incorporating recent reviews and to identify whether these alternative initiatives have benefited patients’ health outcomes in specific diseases, medication management, and quality of life.
Method: A systematic literature search was executed on SCOPUS, Web of Science (WOS), and PubMed databases from the time of inception to April 23, 2023, to recognize recent reviews and observational studies related to the alternative initiatives that can be pursued by community pharmacies beyond DS. Inclusion criteria were community pharmacy setting, community pharmacists’ population, full articles published in the English language, and articles published from 2018 to 2023.
Results: The review included a total of 19 studies, which consist of 15 review papers, 1 study was a pilot randomised control trial (RCT), and another 3 were observational studies (cross-sectional, cohort, and multicentre descriptive studies). Community pharmacists conducting medication reviews and providing educational counseling were the most common in the 9 included literature searches. These are followed by specialized care services for specific diseases or illnesses being offered by community pharmacists underlined in 9 included studies, such as management of anticoagulation, minor ailments, epilepsy care, chronic pain intervention, obesity and weight services, medicine and alcohol consultation, and other chronic diseases care such as diabetes and hypertension. There were another 3 studies that highlight the expansion of community pharmacists’ services and their responsibilities in preserving continuity of care for society during public health emergencies. Key findings from all 19 studies exhibited a good impact on patient’s adherence to the medication, medication management, significant reduction in DRPs and severity of the diseases, increased detection of ADRs, optimized therapy in chronic diseases, and improved patients’ clinical and health outcomes.
Conclusion: Despite the nonexistence of DS policy and its unrealistic implementation within community-based pharmacist practitioners, becoming “indispensable” and evolving to community-based patient care service delivery covering medication optimization, wellness and prevention, chronic and acute care management, and patient education could be successful practice opportunities for community pharmacists.
Effectiveness of Propolis Application in Wound Healing of Third Molar Mandibula Post Odontectomy (Clinical and Radiographic Analysis) - a Comparative Study
Authors: Fauzi Abul , Rasul Irfan , Chandha M. Hendra , Sabir Ardo , Yudha I Gede Arya Wira
Published: May 2024

Background: Dental impactions are commonly encountered by oral surgeons. Potential complications after odontectomy are infection, swelling, and trismus. Propolis is a natural mixture for anti-inflammatory, anti-tumor, anti-oxidant, and immunomodulatory.
Objective: To determine the effectiveness of propolis administration in reducing pain intensity, edema, trismus, and increasing periodontal tissue healing, overall density, and trabecular pattern score.
Materials and methods: Experimental research with the post-test-only control group design. The sample size was 30 patients which were divided into 2 groups, Trigona sp. propolis propolis administration in the mandibular third molar socket after odontectomy and without propolis administration. Statistical tests used the Shapiro-Wilk normality test, the Mann-Whitney comparison test, and the unpaired T-test.
Results: The effectiveness of Propolis was seen in significant values of the comparison of pain intensity and edema from control day 0 to days 1, 3, and 7 (p≤0.05) while trismus and periodontal tissue healing were only seen in the control comparison day 0 with days 3 and 7. A comparison of trabecular values and radiographic periapical density showed a significant value in controls on day 0 and week 8 (p≤0.05).
Conclusion: Trigona sp. Propolis has been proven to be effective in helping improve wound healing after mandibular third molar odontectomy.
Optimization of an SOC green hydrogen production storage and transportation system based on electricity-heat-gas multi-energy coupling
Authors: He Yaqing , Wang weiqing , Li Jiarong , Zhao Chenhuan , Zhang Xinyan , Liu Bowen
Published: May 2024

Considering the randomness and fluctuating characteristics of wind and light resources, there are major challenges associated with the production and supply of green electricity. On the other hand, conventional hydrogen production employing the electrolysis of water has a generally low efficiency, with complex hydrogen storage and transportation processes. Through examining the characteristics of solid oxide cell (SOC), this paper proposes a synergistic optimization model for an integrated cycle of SOC hydrogen storage electricity-heat-gas multi-energy system with a hydrogen-doped natural gas pipeline network. First, an overall optimization model of the electricity-heat-gas multi-energy coupling system is established, including wind power, photovoltaic units, heating system, SOC battery, hydrogen transmission and transportation system, and auxiliary equipment, in addition to harnessing the efficient use of waste heat. Then, an analysis is conducted to study the green power output uncertainty constraints and the energy conservation constraints of the electricity, heat, and gas system. Also, the operational constraints for H2 production, storage, and transport are examined. On this basis, the optimal solution is derived through integration and optimization. Finally, a simulation experiment is performed, considering an electricity-heat-gas multi-energy flow system in an industrial park in Xinjiang, China. The results showed that SOC hydrogen storage improves green power consumption and capacity compared to conventional storage. It also reduces the economic operating costs of the system and accelerates the near-zero carbonization of the investigated industrial park. Additionally, an evaluation is carried out to examine the electrical heat ratio coefficients of the regulated combined heat and power (CHP) system, the tunable hydrogen production efficiency, and the heat consumption efficiency of SOC systems. This allows for optimizing comprehensive hydrogen production efficiency. Also, a study is presented to quantify the impacts of different proportions of hydrogen-doped natural gas on compressor performance, gas network nodes, pipeline transportation characteristics, and gas consumption load. The findings provide a solid theoretical basis for large-scale harnessing of renewable energy, along with efficient, economic, and safe long-distance transportation of massive amounts of H2.
Comprehensive analysis of pepper (Capsicum annuum) RAV genes family and functional identification of CaRAV1 under chilling stress
Authors: Pei Minkun , Yang Ping , Li Jian , Wang Yanzhuang , li Juan , Xu Hongjun , Li Jie
Published: May 2024

Background
The RAV gene family in Capsicum annuum remains largely unexplored in response to chilling stress, despite its known significance in plant abiotic stress responses.
Results
In this study, we identified and characterized six members of the CaRAVs gene subfamily in pepper through genome-wide analysis. Subsequently, the CaRAVs subfamily was classified into four branches based on homology with Arabidopsis thaliana, each exhibiting relatively conserved domains within the branch. We discovered that light response elements accounted for the majority of CaRAVs, whereas low-temperature response elements were specific to the NGA gene subfamily. After pepper plants were subjected to chilling stress, qRT-PCR analysis revealed that CaRAV1, CaRAV2 and CaNGA1 were significantly induced in response to chilling stress, indicating that CaRAVs play a role in the response to chilling stress. Using virus-induced gene silencing (VIGS) vectors, we targeted key members of the CaRAVs gene family, resulting in plants with increased susceptibility to chilling damage and reduced antioxidant enzyme activity, particularly evident under repeated chilling stress. These findings suggest that CaRAV1 and CaNGA1 positively regulate the response to chilling stress.
Conclusions
Silencing targeting key members of the CaRAVs gene family, results in plants with increased susceptibility to chilling damage and reduced antioxidant enzyme activity in plants, particularly evident under repeated chilling stress. This present study provides valuable information for understanding the classification and putative functions of the RAV transcription factors in ppepper.
Predictability of Extreme Rainfall Events During Southwest Monsoon (Mswm) Season in Myanmar: A Physics- Based Empirical Modeling Approach
Authors: Oo Kyaw Than , Jonah Kazora
Published: May 2024

The study looks at how well we can predict extreme rainfall days (ERDs) in Myanmar, a country that often experiences heavy flooding due to intense rainfall. The researchers used a special model based on physics and real-world data to see if they could forecast ERDs effectively. They collected rainfall records and various atmospheric ERA5 reanalysis data from evaluate by 79 different stations in Myanmar to develop the model. The results showed that ERDs happen more in certain regions of Myanmar during specific seasons, and certain atmospheric conditions are linked to these events. The physics-based model used in the study proved to be more reliable than statistical methods for predicting ERDs. The relationships between predictors and predictands may change over time, affecting the model's accuracy. The study helps us understand and predict extreme rainfall events in Myanmar using a physics-based model and identifies important atmospheric factors that influence them. This knowledge is vital for society and science. However, more research is needed to address the limitations and improve the accuracy of predictions in the future.
DFT Investigations on the Thermoelectric, Electronic, Optoelectronic, Elastic, and Structural Properties of K 2 NaTIX 6 (X=I, Br, and Cl) Double Perovskite
Authors: Shah Syed Hatim , song Peng , Huang Taihong , Lu Jiansheng , Bahajjaj Aboud Ahmed Awadh , Batool Kiran , Murtaza G.
Published: May 2024

Despite Pb-based perovskites, sodium-based halide double perovskites (HDPs) provide a bright future for the production of safe solar and thermal energy conversion of devices. These compounds are highly durable, and their elements are non-toxic. So, the present study investigates the thermoelectric, electronic, optoelectronic, elastic, and structural properties of K2NaTIX6 (X = I, Br, and Cl) double perovskite compounds derived from halides using Density Functional Theory (DFT). Investigated compounds are grouped as cubic, and as the halogens are substituted from chlorine to iodine their structural parameter increases. The structural stability is verified through the calculation of the, enthalpy of formation, Pugh's ratio and tolerance factor. The ductile nature is confirmed by Pugh’s ratio of compounds. The halide compounds under investigation all have a direct band gap (3.52, 2.14, and 0.72 eV), granted that the valence and conduction band maxima and minima have the same nature, which results to higher effective mass values. The present investigation focuses on analyzing the refractive index, absorption of light energy, optical loss, and polarization across the entire energy range from 0 to 8 eV. The spectral characteristics suggest that the studied HDPs have the ability to be employed in optoelectronic and photovoltaic devices because of the visible and ultraviolet spectra absorption occurring in this region. The high figures of merit (0.74–0.75) resulting from the calculated power factor and thermal conductivity indicate that these compositions have the capacity to function as thermoelectric devices. These investigations offer a profound comprehension of these materials for their further employment.
Validation and benchmarks for the Copenhagen Psychosocial Questionnaire (COPSOQ III) in an Australian working population sample
Authors: Rahimi Mark , Arnold Ben , LaMontagne Anthony D. , Riley Philip
Published: May 2024

Background:
This study presents an analysis of the reliability and validity of the long version of the Copenhagen Psychosocial Questionnaire (COPSOQ III) in Australia and establishes benchmarks for key dimensions of psychosocial work environment.
Methods:
A random sample was sourced from a panel of 2,446 working Australians aged 18-79. The study establishes population benchmarks for key measures of the psychosocial work environment and employee mental health, and assesses variation by gender, employment status, work sector, professional status, and occupational classification. Validation entailed an assessment of internal consistency reliability of the measures, followed by a preliminary Exploratory Factor Analysis (EFA) to initially examine construct validity of the instrument, and continued with a Confirmatory Factor Analysis (CFA) to validate the scales. Working population mean scores for the key dimensions of COPSOQ-III were calculated and presented as benchmarks for use in workplace risk assessment and management.
Results:
Except for one measure, the analysis revealed strong reliability coefficients for 31 measures with more than two items (>0.7). Only one measure for ‘demand for hiding emotions’ with more than two items had a reliability coefficient of 0.663. The EFA unveiled a four-factor structure in psychosocial working conditions, and a two-factor model in factors related to the effects. The CFA involved item-level analysis, leading to the removal of seven items to improve model fit.
Conclusion:
The present study provides a high-level validation of the long version of COPSOQ, and thus supports its use as an instrument for research as well as psychosocial risk assessment and management in Australia.
Ambulatory Atrial Fibrillation Detection and Quantification by a wrist-worn AI-device Compared to Standard Holter Monitoring
Authors: ronner eelko , vliet mariska van , aalberts jan , hamelinck cora , hauer aernout , hoftijzer hendrieke , monnink stefan , schipper jurjan , peters nicholas , Lip Gregory , Steinhubl Steven , ronner eelko
Published: May 2024

Introduction
Timely detection of atrial fibrillation (AF) is crucial for the prevention of serious consequences such as stroke and heart failure, yet it remains challenging due to its often asymptomatic or paroxysmal nature. Wearable devices with artificial intelligence algorithms offer a promising solution.

Methods
AF detection by the CardioWatch 287-2 (CW2), a wrist-worn photoplethysmography (PPG) and single-lead ECG device, was compared to 24-hour Holter recordings. Patient compliance, AF prevalence and AF burden were evaluated for a further 27 days.

Results
Data from 150 participants (mean age 64 ±12 SD; 41% female) were analysed. The CW2’s PPG and single-lead ECG algorithms achieved a specificity above 98% and sensitivity above 95% for AF detection, and a correlation of 99% for AF burden, compared to 24-hour Holter. AF prevalence increased from 14.7% (24-hour Holter) to 26.7% (28-day CW2).

Conclusion
The wrist-worn CW2 device showed promising performance in detecting AF and determining AF burden.
Application of Robust Mean-Difference Filtering to Relative Navigation of Formation Spacecraft
Authors: Huang Mingkai , Gao Tianci
Published: May 2024

This paper firstly introduces the basic knowledge required for relative navigation of formation spacecraft, which involves the description of the main coordinate systems, the modelling method of relative orbit dynamics of formation spacecraft, the introduction of common interstellar measurement models and the description of the measurement model of the measurement sensors, and then it is divided into two subsections to study the relative navigation problem of the formation spacecraft in two cases.
Aiming at the problems of low filtering accuracy and slow convergence speed of the traditional extended Kalman filtering algorithm for formation spacecraft relative navigation, and considering the linear GPS measurement model, this paper simplifies and applies the standard mean difference filtering algorithm to spacecraft formation relative navigation. Simulation results show that the Simplified Divide Difference Filter (SDDF) proposed in this paper is suitable for the design of formation spacecraft relative navigation filters.
In view of the non-Gaussian characteristics of the GPS measurement system in spacecraft formation flight, the Huber-based Divided Difference Filter (H-SDDF) algorithm is used to improve the robustness of the above SDDF algorithm, and is applied to the design of relative navigation filters for spacecraft formation flight, and the simulation results verify that the H-SDDF algorithm proposed in this paper is suitable for the design of relative navigation filters for spacecraft formation flight. The simulation results verify the effectiveness of the H-SDDF algorithm proposed in this paper.
In summary, this paper focuses on the robust mean difference filter algorithm. The research includes the design of relative navigation filter algorithm for formation spacecraft and the full nonlinear state estimation problem when both the filter system and the measurement model are nonlinear. The main problems solved are: improving the filter estimation accuracy and enhancing the robustness of the filtering process. Finally, theoretical analyses and numerical simulations verify that the research done in this paper has a certain degree of improvement compared with the previous ones.