bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Pengolahan Mie Basah dan Permen Gummy Berbasis Buah Buni untuk Meningkatkan Asupan Gizi dan Ekonomi Masyarakat
Authors: Canti Meda , Yanti
Published: June 2024

Asupan makanan yang kaya akan kandungan gizi seperti buah buni dapat menjadi solusi untuk mengatasi defisiensi vitamin C. Namun pemanfaatan buah buni saat ini masih terbatas karena kurangnya pengetahuan masyarakat dalam mengolah buah buni. Oleh karenanya diperlukan pelatihan pengolahan buah buni menjadi produk yang memiliki nilai tambah seperti mi basah dan permen gummy. Tujuan pelatihan ini ialah memberikan wawasan pengetahuan masyarakat mengenai manfaat dan pengolahan buah buni menjadi produk mi basah dan permen gummy. Metode pelaksanan kegiatan ini ialah pelatihan (penyampaian materi dan demonstrasi). Sebanyak 100% peserta sangat setuju bahwa pelatihan ini sangat bermanfaat dan memberikan wawasan pengetahuan mengenai manfaat gizi dan pengolahan buah buni. Peserta berhasil secara mandiri membuat mi basah dan permen gummy. Pendampingan berkelanjutan diperlukan bagi peserta yang ingin berwirausaha dengan produk olahan mi basah dan permen gummy berbasis buah buni.
Clinical Changes and Autoantibody Level Changes in Thyroid Eye Disease Patients after Intravenous High-dose Steroid therapy
Authors: Jeong Jee Hyun , Lee Dong Cheol
Published: June 2024

Purpose: To evaluate the effects of intravenous steroid therapy on the clinical activity score (CAS), exophthalmos, margin-reflex distance 1 (MRD1), and autoantibody levels in patients with thyroid eye disease.Methods: In this retrospective observational study, we enrolled 83 patients diagnosed with thyroid eye disease treated with intravenous steroid therapy. We assessed exophthalmos, MRD1, CAS, thyroid-stimulating antibody (TSAb), and thyroid-stimulating hormone receptor antibody (TSHR Ab) levels at baseline, 6 and 12 weeks after initiating therapy, and 2 months after therapy termination. Additionally, baseline serum selenium levels were examined to determine their impact on treatment efficacy.Results: TSAb, TSHRAb, and CAS levels showed a continuous decline from 443.22 to 341.03 specimen-to-reference control ratio (SRR%), 22.18 to 7.91 IU/L, and 3.37 to 1.88, respectively (p < 0.0001), up to 2 months following therapy termination. Exophthalmos did not show significant changes at any assessed time point up to 2 months after therapy termination. MRD1 decreased until 12 weeks after therapy initiation but showed no significant change 2 months later. No correlation was found between baseline serum selenium levels and changes in exophthalmos, MRD1, TSAb, TSHR Ab, or CAS.Conclusions: Intravenous steroid therapy was effective in reducing TSAb, TSHR Ab, and CAS levels up to 2 months after therapy termination. However, it had limited positive impact on exophthalmos or eyelid retraction. Baseline selenium levels did not correlate with the changes in any of the examined parameters.
Changes in Ocular Surface Status after 25-gauge Pars Plana Vitrectomy
Authors: Chae Su Bong , Kim Dong Geun , Kwak Hyun Duck
Published: June 2024

Purpose: We used a noninvasive ocular surface analyzer to explore changes in the ocular surface parameters of patients who underwent 25-gauge pars plana vitrectomy (PPV).Methods: The medical records of 82 patients (163 eyes) who underwent PPV were retrospectively reviewed. The non-invasive tear film break-up time (NIBUT), the lipid layer thickness, meibomian gland loss status, and the tear meniscus height were measured before, and 1 and 3 months after treatment. Consecutive changes in the ocular surface indices of operative and non-operative fellow eyes were statistically compared. Also, factors that reduced the NIBUT at 1 month after surgery were analyzed.Results: One month after surgery, the NIBUT was significantly decreased in the operative group compared to before surgery (p = 0.006). Compared to non-operative eyes, the NIBUT of operative eyes decreased significantly 1 month after surgery (p = 0.003). Older age and lower preoperative NIBUT (p = 0.029, p = 0.002) were significantly associated with lower NIBUT 1 month after surgery.Conclusions: Twenty-five gauge PPV significantly reduces the NIBUT 1 month after surgery.
Clinical Results of Prosthetic Eye Wear in Patients with Congenital Microphthalmos
Authors: Lee Phil Kyu , Cho Won-kyung , Paik Ji Sun , Yang Suk-Woo
Published: June 2024

Purpose: To report the long-term clinical outcomes of non-surgical treatment involving prosthetic eye wear in patients diagnosed with congenital microphthalmos.Methods: A retrospective review of the medical records of 20 patients was conducted. In total, 21 eyes were diagnosed with congenital microphthalmos between May 2008 and December 2022 at Seoul St. Mary’s Hospital in Korea.Results: This study included 20 patients (12 males and 8 females) with an average age of 4 months at diagnosis. The observed ophthalmic anomalies included two cases of congenital cataract, one of posterior embryotoxon, one of corneo-iris strand, four of iris coloboma, five of central corneal opacity, one of Peter's anomaly, and one of retrobulbar cyst. Accompanying systemic abnormalities were noted, such as lateral ventricle atrophy, corpus callosum atrophy, patent ductus arteriosus, atrial septal defect, and developmental language disorder. Genetic anomalies included anti SS-A/Ro antibody positivity, a 1:100 titer of anti-nuclear antibody, and a PAX6 mutation identified through next-generation sequencing. No specific family histories or pregnancy-related factors were noted. The average follow-up duration was 5.94 years (range: 1 month to 18 years), the average corneal diameter was 4.6 mm, the average axial length was 17.44 mm, the average age for first artificial eye trial was 5.96 years (range: 7 months to 19 years), and the average interval for artificial eye replacement was 22 months (range: 4 months to 5 years and 8 months).Conclusions: Twenty patients with congenital microphthalmos underwent gradual expansion of their prosthetic eyes by regular replacement and size increase without severe complications. This approach led to aesthetically and emotionally positive outcomes for the patients.
The Diagnosis and Treatment of a Post-traumatic Iris Cyst Referred as an Iris Tumor
Authors: Yoon Ji Hyun , Yoon Young Chae , Park Sun Kyoung , Whang Woong Joo , Hwang Ho Sik , Kim Hyun Seung , Na Kyung Sun
Published: June 2024

Purpose: We report the diagnosis and treatment of a secondary iris cyst in a patient referred for an iris tumor.Case summary: A 29-year-old man diagnosed with an anterior chamber mass of the left eye was referred to our center for further evaluation and management. Twenty years previously, he suffered a penetrating ocular injury of his left eye and underwent primary closure. He had no underlying systemic disease. At his initial visit, the best corrected visual acuity of his left eye was 0.5. A whitish-gray mass was observed within the anterior chamber from 1 o'clock to 5 o'clock, obscuring the pupil. Anterior segment optical coherence tomography revealed a cystic mass touching the retrocorneal surface. No other lesions were seen on orbital imaging or ocular ultrasonography. Ultimately, it was diagnosed as an iris cyst that occurred secondary to ocular trauma. After needle aspiration and intracystic injection of 99% ethanol, the cyst collapsed fully. However, a cataract developed within a few months, and phacoemulsification and intraocular lens implantation were performed. Seven months after cyst aspiration, the uncorrected visual acuity of the left eye had recovered to 0.5. The cyst still adhered to the corneal endothelium, remaining in its collapsed state. The current corneal endothelial cell density is 871 cells/mm2.Conclusions: A secondary iris cyst was diagnosed in a patient with a history of penetrating eye trauma and surgery. It was treated successfully with needle aspiration and intracystic alcohol injection.
Two Cases of Ischemic Optic Neuropathy after Extracorporeal Membrane Oxygenation (ECMO)
Authors: Han Kwang Eon , Kim Sang Yoon , Kim Su Jin
Published: June 2024

Purpose: We report two cases of non-arteritic ischemic optic neuropathy (NAION) following extracorporeal membrane oxygenation (ECMO) treatment.Case summary: (Case 1) A 36-year-old man underwent ECMO treatment. Upon regaining consciousness, he complained of a darkened peripheral visual field and was subsequently referred to an ophthalmologist. His best-corrected visual acuity was 0.9 in the right eye and 0.8 in the left eye. The intraocular pressure measured 12 mmHg in the right eye and 10 mmHg in the left eye; color vision was normal. A visual field test demonstrated concentric visual field defects in both eyes, and a fundus examination revealed a pale optic disc. Optical coherence tomography (OCT) indicated a decrease in retinal nerve fiber layer (RNFL) thickness. (Case 2) A 48-year-old woman underwent ECMO treatment. After regaining consciousness, she reported decreased vision in her right eye. Her best-corrected visual acuity was limited to hand motion in the right eye and was 1.2 in the left eye. A relative afferent pupillary defect in the right eye was observed. Color vision in the right eye was compromised, and a fundus examination revealed a pale optic disc. A visual field test demonstrated total visual field defect in the right eye, while OCT showed decreases in both the RNFL thickness and the ganglion cell-inner plexiform layer thickness of the right eye. Magnetic resonance imaging (MRI) revealed high signal intensity and abnormal enhancement in the right retrobulbar optic nerve.Conclusions: In cases where vision loss and visual field defects are observed following ECMO treatment, differential diagnoses for ischemic optic neuropathy are warranted.
Influence of Social Acceptance on Emotions, Hope and Resilience among Imprisoned Women in India
Authors: Sharma Adyaa
Published: June 2024

Imprisonment in law is the specific state of being physically incarcerated or confined in an institutional setting such as a prison, which has an impact on a person’s physical, emotional and behavioural well-being. Social acceptance is the desire to form and maintain close, lasting relationships with others. Emotions are defined as a complex state of feeling that results in physical and psychological changes that influence thought and behaviour. Hope is defined as the perception that one can reach desired goals. Resilience refers to a class of phenomena characterised by patterns of positive adaptation in the context of significant adversity or risk. The purpose of this study is to determine the influence of perceived social acceptance of women prisoners on their dominant emotions (i.e., positive or negative). The study also examines the relationship between the dominant emotions and their impact on the hope and resilience of the women prisoners. The data of 55 women prisoners is collected from the Women’s Jail Cell, Central Jail Tihar, New Delhi and data is analysed. A Pearson Correlation is calculated to establish a relationship between Perceived Social Acceptance and Positive Affect and Negative Affect, which results as— Perceived Social Acceptance correlates positively with Positive Affect and negatively with Negative Affect, however, the results weren’t statistically significant (p>0.05). In addition, an independent t-test between Positive Affect, Negative Affect, Hope and Resilience showed that women inmates with dominant Positive Affect positively impacted their Hope and Resilience (p<0.05). The results are discussed within the framework of the literature.
Dopaminergic Drugs for the Successful Treatment of Bullous Pemphigoid (BP)
Authors: Check Jerome H , Neumann Brooke , Check Diane L
Published: June 2024

The case presented here describes a novel treatment for bullous pemphigoid that was extremely effective in a 68-year- old woman with a history of multiple sclerosis who developed a severe case of histopathologically confirmed diagnosis of bullous pemphigoid involving her trunk, back, and upper thighs. The lesions developed despite her 1 1⁄2 years of treatment with the immunosuppressive agent ocrelizumab prescribed to treat multiple sclerosis (MS). A well-known physician at a university medical center who diagnosed the BP prescribed tetracycline, but this showed no clinical benefit. She was treated with dextroamphetamine for the purpose of releasing more dopamine from sympathetic nerve endings. Dopamine is known to decrease cellular permeability, thus inhibiting hypothetical irritants from infusing into the skin causing this type of inflammatory response. She had been previously treated for over 30 years with dextroamphetamine, which completely stopped rapid progression of MS. She moved 1000 miles, and her neurologist switched her to ocrelizumab because of unfamiliarity with treating MS with dopaminergic drugs and prescribed her ocrelizumab. She had a total remission of her BP in one week. She has not had any more skin lesions now for over a year while on therapy. Since current medical treatments for BP are not very affective and with the knowledge that dextroamphetamine has previously demonstrated efficacy in ameliorating other severe treatment resistant skin disorders e.g., urticaria, eczema, and psoriasis, and mucous membrane disorders e.g., recurrent aphthous stomatitis, this off-label safe treatment should be considered for BP in treatment resistant cases.
Identifying Atypical Familial SLE in the American Indian/Alaska Native Population
Authors: Alexander Caleb S , Kaushik Prashant
Published: June 2024

Systemic lupus erythematosus (SLE) is a major chronic systemic inflammatory autoimmune condition that affects all demographics of the population; however, it is typically thought to be a disease primarily of females since about 9 in 10 diagnosed cases are in female patients. While there are studies describing the prevalence of disease in the American Indian/Alaska Native (AI/AN) population, few individual cases are highlighted. We present a pair of cases among two AI/AN full-blood brothers, who are members of the Cherokee Nation (CN), Oklahoma.
Ethnopharmacological Properties of Some Plants of the Asteraceae Family which Are Distributed in the Territory of Azerbaijan
Authors: Gurbanova L.
Published: June 2024

The article provides information about the ethnopharmacological and nutritional properties of some plants of the Asteraceae family, common in Azerbaijan and widely used in folk medicine. Although ethnic knowledge is passed down from generation to generation, some information is forgotten if not documented. Therefore, we set ourselves the goal of studying plants of the Asteraceae family, as well as their use in ethnopharmacology. The organs and phases of plants used as medicines have been clarified, and their nutritional value has been determined. It has been established that members of the family are eaten both raw and cooked. Medicinal value varies. Species of the Asteraceae family are mainly used for diabetes, infectious diseases, and also as an expectorant, choleretic, and anticancer agent.
Botanic-Geographical Analysis of Mesothermic Relicts of Turgai Flora of Azerbaijan
Authors: Qarayev S.
Published: June 2024

From the middle of the Oligocene epoch of the Paleogene period evergreen Poltava flora had been replaced by deciduous tree species of Turgai flora. The taxonomic composition of the relict trees and shrubs belonging to the Turgai flora in Azerbaijan and their botanical and geographical characteristics are analyzed in this article. In the article also analyzed the characteristics of the relict areal and the genetic varieties that stood the changes in the geological periods, while preserving its gene pool so far. In modern times, Turgai flora remaining relicts are more common in Hirkan (Azerbaijan), in Colchis (Georgia), and partially in the forests surrounding the Southern hills of the Greater Caucasus. Mesothermic plants of Turgai flora in Azerbaijan are found combining 17 families and 28 genera in 38 species of trees and shrubs.
Prerequisites for Hydrocarbon Accumulation and Formation of Deposits in the Lower Cretaceous and Jurassic Sediments of the Borovoye Oil Field
Authors: Korzhov Yu. , Starikov A. , Romanova T. , Kuzina M.
Published: June 2024

The work analyzes the tectonic development of the Borovoye area and studies the lithological characteristics of the Jurassic and Cretaceous sediments of the study area. Possible migration paths of hydrocarbons in the context of Jurassic and Cretaceous strata and their connection with basement rocks are considered.
Digital Terrain Model as a Basic Element of Corporate GIS (Using the Example of the Toratau Geopark)
Authors: Nigmatullin A. , Gonchar A. , Atnabaev A.
Published: June 2024

The scientific article is devoted to the study of methods for obtaining three-dimensional terrain models using modern technologies of remote sensing of the Earth. Various techniques are considered, including interpolation of elevation points and isolines, the use of satellite images and lidar photography by means of unmanned aerial vehicles. The arguments in favor of using lidar photography to create a digital terrain model in the context of creating a corporate geoinformation system for the Toratau geopark are presented.
Cultivation Technologies and Inorganic Fertilizer Norms when Growing Potatoes in Azerbaijan
Authors: Asgarov E. , Mirzaliyev V.
Published: June 2024

Technologies for applying granular fertilizers when growing potatoes in the farms of the Gazakh-Tuz economic region of Azerbaijan are presented. An analysis of existing technical means used to effectively prepare soil for growing potatoes was carried out. By means of a stepwise supply of inorganic fertilizers to the soil using the method of differentiated distribution, theoretical studies were carried out and analytical expressions were obtained to substantiate the parameters of the working bodies of the corresponding unit. An analysis of existing technologies and technical means for growing potatoes shows that the application of fertilizers, which provide the required amount of nutrition for the cultivated crop, prevents sufficient nutrition of the soil when carried out in a surface manner and subsequent incorporation into the soil. To avoid this, inorganic fertilizers are applied to the soil by working groups and converted into the soil by cutting off lower layers to protect the mound and optimal soil structure. By systematically filling the soil through differentiated distribution of inorganic fertilizers, analytical studies were carried out and analytical expressions were obtained to check the parameters of the unit’s labor force.
Potatoes Performance in Rainfed Conditions on the Chernozems of the Gedabek District of Azerbaijan
Authors: Makhmudova E.
Published: June 2024

The results of research for the period 2014-2017 are presented. Experimental work was carried out in the village of Chaldash, Gedabek district of Azerbaijan. The yield of potatoes of the Sevinj variety was determined depending on the number of inorganic fertilizers applied to the soil. Soil samples were taken from depths of 0-20 and 20-40 cm. Absorbed ammonium nitrogen (N/NH4) and nitrate nitrogen (N/NO3) were determined. Soil samples were taken at 3 stages of plant development: budding, flowering and potato ripening. Conducted studies show that yields have increased noticeably in options where mineral and organic fertilizers are applied in different rates and proportions. The highest results were obtained in the variant N93P98K126+Gyps163+20 tons of manure.
Literature Review: Current Status of Surgical Treatment of Colorectal Tumor
Authors: Maikanaev B. , Mamakeev K. , Ashimov Zh. , Osmonbekova N. , Aitmoldin B. , Shahd H.
Published: June 2024

The article is based on the study and comparison of surgical interventions on the large intestine for neoplasms. The aim of the study: to investigate and compare surgical interventions based on the efficacy, safety of mixed endoscopic surgeries and laparoscopic surgeries not subject to endoscopic removal of neoplasms. 17 randomized prospective and retrospective observations were selected for this work, the observations were divided into two groups, the first group of patients who underwent surgical intervention by hybrid laparo-endoscopic method and the second group of patients who underwent laparoscopic resection of the colon. The total number of patients amounted to 835 (100%) of which 517 (61,9%) were included in the first group and the second group consisted of 318 (38,1%) patients. The results of the study showed that in the first group the duration of the operation and the patient’s stay in hospital were statistically significantly shorter than in the second group (mean difference = -38.7 minutes; 95% CI -51.4 -26.0; p < 0.00001, bed-day mean difference = -2.3 days; 95% CI -3.17 - -1.57; p < 0.00001). And in terms of the incidence of postoperative complications, recurrence and mortality, no significant differences were observed between the groups (p = 0.05). Patients who underwent hybrid laparo-endoscopic surgeries with benign endoscopically unresectable colorectal neoplasms do not increase the incidence of postoperative complications and lethality. The advantage of this method is the reduction of bed-days and duration of the operation also time.
Principles of Organization of Multidisciplinary Clinics and Pain Treatment Centers (Literature Review and Own Experience)
Authors: Yarikov A. , Perlmutter O. , Fraerman A. , Tsybusov S. , Volkov I. , Romanov S. , Abaeva O. , Pavlova E. , Sosnin A.
Published: June 2024

Pain is one of the most important problems of modern medicine. The high prevalence of pain causes significant material and social losses. As an effective measure to solve this problem, the idea of organizing a network of pain treatment centers and clinics was put forward. The purpose of the work is to describe the structure of the organization of multidisciplinary clinics and pain treatment centers. The article discusses the basic principles of the organization of pain treatment centers and the system of analgesic care. An example of the work of the pain center on the basis of a multidisciplinary hospital (Volga District Medical Center of the FMBA of Russia) is given. The authors shared the structure and organization of the work of this pain treatment center. They also presented the results of his work. Currently, there are no specialized pain centers in Russia. Now in many cities of Russia there is a process of formation of analgesic care. However, this process faces a number of difficulties.
Contents of IL-1β and IL-10 in Blood Plasma Dynamics in Experimental Animals during Simulation of Wound Process of Soft Tissue in Low Altitude Conditions and During the Period of Deadaptation to High Altitudes
Authors: Mamakeev K. , Umetaliev Yu. , Abdyshev E. , Niyazov B. , Niyazova S. , Mamatov A.
Published: June 2024

Presents the dynamics of the content of IL-1β and IL-10 in the blood plasma of experimental animals when modeling a wound process in low-altitude conditions and during the period of deadaptation to high-altitude conditions. The animals were divided into 3 series: Series I — control (permanently living in the conditions of Bishkek); Series II — experimental, after a 3-day stay at the experimental high-mountain base of KSMA named after. A. A. Raimzhanov as part of the Central Research Laboratory (moved to the conditions of Bishkek with subsequent modeling and observation of the course of the wound process); III series — experimental, after a 30-day stay at the experimental high-mountain base of KSMA named after. A. A. Raimzhanov as part of the Central Scientific Research Laboratory (moved to the conditions of Bishkek with subsequent modeling and observation of the course of the wound process). Analysis of the data obtained shows that during aseptic inflammation, the opposite dynamics of the production of some of the key interleukins was observed, with IL-1β with a maximum concentration 12 hours from the onset of aseptic inflammation. The identified changes in the content of cytokines during experimental aseptic inflammation determined the timely change and adequate duration of cellular reactions. During purulent inflammation, the dynamics of cytokine secretion was unidirectional, which led to a delay in time of all cellular phases of the inflammatory process. During the period of deadaptation after a long stay in high altitude conditions, low secretion of IL-1 and IL-10 is observed, associated with the depletion of protective and adaptive mechanisms.
Modern Diagnostic Approaches and Management Tactics for Patients with Chronic Colonic Stasis in Decompensated Forms of Colon Dysfunction
Authors: Aitmoldin B. , Rustemova K. , Mamakeev K. , Kabduaisova A. , Gadylbekov A.
Published: June 2024

Today, colonic stasis is a significant medical and social problem worldwide. According to research by a number of authors, in developed countries, constipation affects to varying degrees from 30 to 50% of the working-age population and from 5 to 20% of children. Constipation occurs 5 times more often in the elderly than in young people. The etiology of chronic colonic stasis is diverse: from functional disorders of gastrointestinal motility to intestinal abnormalities, in some cases leading to disability and a significant decrease in the quality of life of patients. Prolonged, sometimes unsuccessful, medical treatment of chronic colonic stasis ultimately raises the question of the need for surgical intervention. The purpose of this review was to study and summarize the results and experience of researchers over the past 10 years devoted to the search for the most effective methods of surgical treatment of chronic colonic stasis in decompensated form of colon dysfunction (including dolichosigmoid) in combination with drug therapy. The search for information for the review was carried out on the following resources: PubMed, MEDLINE, Embase, Springer, ScienceDirect, journals of the CIS countries and the Republic of Kazakhstan.
Features of the Epidemiological Process of Measles Incidence in the Rural Population in the Territory of FGP no. 7 in the City Family Doctors Center Jalal-Abad of the Kyrgyz Republic for 2023
Authors: Temirov N. , Temirova V. , Zholdoshev S. , Kodirov R.
Published: June 2024

The article discusses the features of the epidemiological process of the incidence of measles infection in the rural population in the territory of the group of family doctors (FGP) No. 7 in the Family Medicine Center (FMC) in the city of Jalal-Abad. On the territory of FGP No. 7, registration of measles infection began from November to December 2023. A high prevalence rate was recorded among young children: in first place were children under one year of age (13.3 per 1000 children); in the second — children 1-2 years old (3.9 per 1000 children); in third place are children 3-5 years old (2.4 per 1000 children) and 6-9 years old (0.9 per 1000 children). No cases of measles were found among adults. By category of cases, a large proportion were unvaccinated children (87.5%), including 42.9% by age and 57.1% among refuseniks. In terms of the number of cases, a large share was made up of unorganized children (87.5%) and children attending kindergartens (12.5%). On the territory of the FGP, in 8 measles foci, a total of 112 contact persons were found, among them there were no cases of measles, however, focality was noted in a family with one case and in two families with two cases each. All contact persons in the outbreaks were vaccinated with MMR and MCV.
Drug discovery and development and precision medicine for Autism Spectrum Disorder – current state
Authors: Stojanovska Irena
Published: June 2024

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder/condition. Medical interven-tions for this condition are mainly pharmacological, and generally not tailored to precisely address the specific underlying issues in each ASD individual. Despite the extensive efforts to develop new or repurpose existing drugs over the decades, the range of medications that address this condition remains very limited.Findings: Progress in drug development has been hindered by research design limitations and the complex, het-erogeneous nature of the ASD itself. Therefore, this article first discusses preclinical and clinical studies aimed at finding effective treatments, highlighting their shortcomings and potential solutions. It then delves into the com-plexity of ASD and the implications for drug development, such as its phenotypic and genetic heterogeneity and multifactorial etiology, and unclear diagnostic boundaries with other developmental disorders.Exploiting the advantages of new technologies, current autism treatment research is steering towards prioritizing genetic and molecular data over phenotypic data, emphasizing the need for biologically meaningful and quantifi-able biomarkers to identify biologically defined and clinically actionable subgroups within ASD, amenable to specific treatments.The critical role of precision medicine is underscored as a comprehensive, fundamental approach to biology-based drug development and personalized treatments. Achieving this goal requires an integrated analysis of multilayered data, utilizing multi-omics, systems biology, and machine learning approaches.Conclusion: Lastly, the article provides a brief overview of current initiatives and private sector efforts focusing on precision medicine treatments for neurodevelopmental disorders, highlighting their progress in developing drugs through this innovative approach.
Stereo 3D cloud motion from tandem satellites
Authors: Zhou Yang , Abrahams Sophie , Mendoza Francisco , Donà Maddalena , Verbiest Rik
Published: June 2024

In this study, we introduce a software framework developed during the SWI 2023 Study Group for accurate geolocation and 3D reconstruction of cloud observations. Jointly proposed by the European Space Agency (ESA) and the Royal Netherlands Meteorological Institute (KNMI), this project extracts and transforms cloud observation data into actionable insights. Implemented primarily in Python3 with libraries such as numpy, matplotlib, and scipy, the framework provides a robust pipeline for processing netCDF data, including cloud observations and locations. It handles three main tasks: reconstruction, motion extraction, and shape analysis. Key procedures include 3D reconstruction, bulk motion extraction, shape analysis, cloud selection and smoothing, and optical flow. The focus is on accurately extracting cloud latitude and longitude from observed positions, considering the true height of the cloud surface.
A brief overview of existing neural network solutions and services for photographers
Authors: Stepanov Andrey
Published: June 2024

This article focuses on neural networks and artificial intelligence systems used to enhance images. It attempted to analyse the maximum range of existing systems that can be used for photography. The aim of the article was to find as many systems and services used to enhance photos, restore details, remove noise and improve image quality, in order to understand how neural networks are becoming useful to a wide range of professionals - photographers, photo editors, bloggers, marketers, designers, photo restorers and some other specialists. This finding of 146 neural networks and AI-based systems is summed up in a table compiled by the author. There is also an analysis of a number of neural network-based solutions that allow photographers to improve their images.
Integration of Ukrainian refugees in Belgium thanks to learning French
Authors: Belyasova Julia
Published: June 2024

This paper considers the integration of Ukrainian refugees in Belgium – French Language assistance in the province of Walloon Brabant in Belgium. The learning of the local language is essential to enable them to orientate themselves, communicate and integrate into French-speaking society. Learning of French plays an essential role in the integration of these refugees in Belgium. It facilitates social interactions, access to employment and understanding of local culture. Initiatives such as the Reception and Schooling Scheme for Newly Arriving and Assimilated Students, the French Language of Education support system, the Local Integration Initiative as well as the applications and sites: Wallangues, “Bonjour Belgique”, First Aid Communication Tool, Alpha French Foreign Language Portal were developed to help Ukrainian refugees learn French, thus promoting their integration into French-speaking Belgian society. Also, several systems and structures studied to teach French quickly and effectively to Ukrainian refugees who arrive in Belgium. As a result of the study, it was found that the level and speed of progression in learning depend on the initial notions of French previously received, the personal motivation and the commitment of Ukrainian learners.
The Market of True Matters: A Novel Approach for Taking Stock of Personal Values
Authors: O’Leary Maggie , Boudreau Marie
Published: June 2024

The field of personal visualization has seen significant advancements, driven by increased personal data and interest in self-improvement. While traditional personal visualization tools focus on behavior tracking, this paper explores an innovative approach to visualizing personal values aligned with users' professional mental models. We present the development of a tool that uses the stock market metaphor to represent individual values, leveraging the business backgrounds of the co-authors. Data collected over a year tracked four values: wisdom, security, curiosity, and love. These values were visualized as stocks, reflecting their daily fluctuations and overall trends. Our work demonstrates that aligning personal visualization tools with a familiar metaphor enhances user engagement and personal development, suggesting new directions for personal visualization research and for one’s approach to life.
Highlighting the Role of Internal Government Audits in Enhancing e-Budgeting Practices in Bengkulu City
Authors: Gaol Lasando Lumban , Suryani Pesi
Published: June 2024

This study highlights the role of internal government audits in enhancing e-budgeting practices in the Bengkulu City Government. Using a qualitative approach with a case study design, data were collected through semi-structured interviews, participatory observation, and document analysis. The findings indicate that the digitalization of internal audits using the Data Collection System (DCS) enhances transparency and accountability in regional financial management. However, challenges include the quality of uploaded data, limited skilled human resources, adequate technological infrastructure, and resistance to change from employees accustomed to manual systems. Recommendations include continuous training enhancement and effective change management strategies to optimize e-budgeting implementation. Further research in other regions is recommended to share best practices and improve public financial management.
Entre o urbano e o rural: o Plano Diretor como ferramenta na delimitação do espaço do povoado da Capela do Rio do Peixe, no município de Pirenópolis (GO)
Authors: Trindade Leiliane Alves , Luz Janes Socorro da
Published: June 2024

O presente trabalho tem o intuito de demonstrar como a criação de uma lei pode estabelecer os espaços territoriais dentro de um município, com a análise do povoado da Capela do Rio do Peixe e sua relação com o Plano Diretor do Município de Pirenópolis (GO), que o delimitou como pertencente à zona rural do município e onde, atualmente, percebe-se um crescente processo de urbanização. Essa fronteira, que delimita o espaço urbano e rural, estabelecida pelo Plano Diretor de um município, interfere diretamente nas normas que devem ser aplicadas em relação ao parcelamento do solo e, por estar em uma área considerada rural, favorece que os novos imóveis não tenham a regularização que a legislação determina, mostrando-nos que a lei nem sempre acompanha a evolução social.
Os testemunhos dos Aikewara nas investigações da Comissão Estadual da Memória e Verdade do Pará
Authors: Tenaglia Monica , Carvalho Carla Jéssica dos Santos
Published: June 2024

As fontes orais tiveram papel fundamental nas investigações das comissões da verdade brasileiras. Este trabalho apresenta a relevância dos testemunhos do grupo indígena Aikewara aos trabalhos da Comissão Estadual da Memória e Verdade do Pará e que contribuíram a visibilidade de memórias ocultas e silenciadas pela ditadura. Como metodologia, caracteriza-se como uma pesquisa qualitativa e descritiva, que utilizou de levantamento bibliográfico e análise dos relatórios finais da Comissão Estadual da Memória e Verdade do Pará e da Comissão Nacional da Verdade. Como resultados, foi possível identificar que os testemunhos assumiram um papel central nas investigações sobre o grupo Aikewara, contribuindo para elucidar as circunstâncias dos abusos e validar as memórias do grupo, de modo a auxiliar na efetivação e reparação da justiça, além de contribuir na visibilidade do sofrimento dos indígenas durante a ditadura militar.
A aliança para o desenvolvimento do Rio Grande do Norte: entre os dólares estadunidenses e a colaboração do governo Goulart (1962-1964)
Authors: Oliveira Roselia Cristina de
Published: June 2024

O artigo discute como o programa de governo de Aluízio Alves (1961-1965), no Estado do Rio Grande do Norte, foi implementado com a colaboração dos Estados Unidos e de agências governamentais, visando combater as mazelas do subdesenvolvimento e consolidar a hegemonia política desse gestor. Como estratégia, Alves buscou estabelecer a imagem de político conservador, reformista e anticomunista, o que lhe rendeu um aporte considerável de recursos financeiros. Esse processo contou com a confluência de interesses de uma aliança conservadora, objetivando controlar o poder político na região Nordeste no período que antecedeu o golpe civil-militar de 1964. Nessa perspectiva, evidencia-se a cultura política local e as relações de poder que mantiveram sob tensão os processos de lembrar e esquecer a memória coletiva. Espera-se que a rememoração desses eventos contribua para identificar zonas de sombra, silêncios e não ditos que invisibilizam o protagonismo potiguar da primeira metade da década de 1960.
Harmonizing success: unraveling the interplay of principal entrepreneurial leadership, teacher efficacy, and organizational effectiveness in English training institutions of China
Authors: Jinke Li , Aziz Nor Azni Abdul , Kadir Suhaida Abdul
Published: June 2024

For a long time, teacher efficacy and organizational effectiveness have been researched in primary, junior high schools or university settings. Training institutions are a special type of profit-making educational organization, there is relatively little research conducted on them. Entrepreneurial leadership is an innovative leadership concept that, to some extent, contributes to improving teacher efficacy and organizational effectiveness, which is rarely studied in the educational domain. In accordance with the tenets of the open social system theory, this study proposed a model that teacher efficacy has a mediation effect on principal entrepreneurial leadership and organizational effectiveness. To evaluate the proposed model and explore the relationships among principal entrepreneurial leadership, teacher efficacy and organizational effectiveness, this study researched 381 teachers in English training institutions via Pearson correlation analysis and mediation effect analysis. The findings showed that positive and significant relations among principal entrepreneurial leadership, teacher efficacy and organizational effectiveness, and confirmed that teacher efficacy has a mediating effect on principal entrepreneurial leadership and organizational effectiveness in training institutions. These findings contributed to expanding the implementation of open social system theory from the three perspectives, providing new comprehension for government educational departments, principals and teachers in the organizational effectiveness of training institutions.
Digital twin technology for enhanced smart grid performance: integrating sustainability, security, and efficiency
Authors: Alharbey Riad , Shafiq Aqib , Daud Ali , Dawood Hussain , Bukhari Amal , Alshemaimri Bader
Published: June 2024

This research paper presents the development and analysis of a multifaceted smart grid prototype. It combines various technologies for the smart grid operation. The first technology is environmental analysis of smart grid and solar panel cleaning. Secondly, radio-frequency identification (RFID)-based security and access control system has been integrated for smart grid. The third component is internet of things (IoT)-based energy monitoring and load management. For environmental analysis sensors such as temperature, humidity, light-dependent resistor, and flame sensors are connected to a NodeMCU controller for real time monitoring. Moreover, IoT based solar cleaning system is developed in the form of prototype with the help of Blynk and servo motor. The second component of prototype is smart security system which is developed with the help of Arduino and RFID module to facilitate secure access control. The third part of prototype employs voltage and current sensors with an ESP32 microcontroller and the Blynk application for real-time energy consumption analysis. This setup enables remote monitoring of voltage, power dynamics, and consumption patterns in a smart grid. It also offers an IoT based solution for load management and load shedding within the smart grid. The complete prototype overall demonstrates a comprehensive approach to 1) smart grid management, 2) environmental analysis, 3) security, and 4) energy monitoring.
Brooding fathers actively consume viable embryos to take up nutrients in a monogamous syngnathid fish
Authors: Lin Tingting , Liu Xin , Li Siping , Zhang Dong , Shen Fengyuan
Published: June 2024

Syngnathid fishes often experience a reduction in brood size and an increase in immunity during pregnancy. Researchers have studied the polygamous broad-nosed pipefish (Syngnathus typhle) and revealed that some eggs from low-quality females in the male’s brood pouch serve as nurse eggs that are absorbed by the father. It is unclear whether nurse eggs also exist in other syngnathid fishes, especially in monogamous syngnathid fishes. In monogamous syngnathid fishes, the male pouch only carries eggs from a single female. Thus, the question remains: do some eggs of monogamous syngnathid fishes also serve as nurse eggs? And if so, are these nurse eggs impaired eggs, or are they viable eggs that are consumed by the brooding father? In the present study, we used the monogamous lined seahorse (Hippocampus erectus) and asked whether nurse eggs exist in this species. We also explored whether nurse eggs potentially originate from viable versus inviable eggs. Using isotope labeling, we found that nutrients from embryos could be transferred to brooding fathers. Furthermore, we also found that brooding fathers with limited food had a higher isotope content and a smaller brood size compared to individuals with sufficient food. These results have demonstrated that nurse eggs exist in the lined seahorse, and also suggested that the brooding fathers actively consume viable embryos to absorb nutrients in response to low food availability. These findings help us better understand parent–embryo conflict, filial cannibalism, and male-only care in teleost fishes.
Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells
Authors: Brunetti Valentina , Berra-Romani Roberto , Conca Filippo , Soda Teresa , Biella Gerardo Rosario , Gerbino Andrea , Moccia Francesco , Scarpellino Giorgia
Published: June 2024

Lysosomal Ca2+ signaling is emerging as a crucial regulator of endothelial Ca2+ dynamics. Ca2+ release from the acidic vesicles in response to extracellular stimulation is usually promoted via Two Pore Channels (TPCs) and is amplified by endoplasmic reticulum (ER)-embedded inositol-1,3,4-trisphosphate (InsP3) receptors and ryanodine receptors. Emerging evidence suggests that sub-cellular Ca2+ signals in vascular endothelial cells can also be generated by the Transient Receptor Potential Mucolipin 1 channel (TRPML1) channel, which controls vesicle trafficking, autophagy and gene expression. Herein, we adopted a multidisciplinary approach, including live cell imaging, pharmacological manipulation, and gene targeting, revealing that TRPML1 protein is expressed and triggers global Ca2+ signals in the human brain microvascular endothelial cell line, hCMEC/D3. The direct stimulation of TRPML1 with both the synthetic agonist, ML-SA1, and the endogenous ligand phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) induced a significant increase in [Ca2+]i, that was reduced by pharmacological blockade and genetic silencing of TRPML1. In addition, TRPML1-mediated lysosomal Ca2+ release was sustained both by lysosomal Ca2+ release and ER Ca2+- release through inositol-1,4,5-trisphophate receptors and store-operated Ca2+ entry. Notably, interfering with TRPML1-mediated lysosomal Ca2+ mobilization led to a decrease in the free ER Ca2+ concentration. Imaging of DAF-FM fluorescence revealed that TRPML1 stimulation could also induce a significant Ca2+-dependent increase in nitric oxide concentration. Finally, the pharmacological and genetic blockade of TRPML1 impaired ATP-induced intracellular Ca2+ release and NO production. These findings, therefore, shed novel light on the mechanisms whereby the lysosomal Ca2+ store can shape endothelial Ca2+ signaling and Ca2+-dependent functions in vascular endothelial cells.
Aspects of acceptance: building a shared conceptual understanding
Authors: Mrazek Michael D. , Dow Bailey R. , Richelle Justine , Pasch Alexander M. , Godderis Nathan , Pamensky Talia A. , Rutila Bryce A. , Mrazek Alissa J.
Published: June 2024

Many contemplatives, scientists, and clinicians have pointed to the value of responding to life’s difficulties by accepting experiences as they are. A growing body of research also suggests that acceptance contributes to effective coping with adversity, reduced stress, and improved emotional well-being. Yet within the scientific literature, there is little consensus on what acceptance means or how it should be measured. This makes it nearly impossible to synthesize empirical work on acceptance into a cohesive scientific understanding. Our goal in this paper is to clarify four facets of acceptance that are commonly referenced in research: acknowledging, allowing, non-judging, and non-attachment. We do not propose a specific definition of acceptance or even a set of privileged facets that must be included in future frameworks. We instead offer a vocabulary to facilitate productive communication among researchers that will, in turn, enable a more definitive scientific understanding of this important construct to emerge. After defining and explaining these aspects of acceptance, we further clarify these constructs in two ways. First, we illustrate how the four aspects are dissociable from one another. Second, we analyze their correspondence to related constructs from Acceptance and Commitment Therapy (ACT). Finally, we provide a concept worksheet that scholars can utilize to precisely operationalize acceptance in their own work.