bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyocyanin is the Microbial Blue-green Pigment: A Review on its History,
Virulence, and Therapeutic Use
Authors: Sahoo Sameer Ranjan , Pradhan Arun Kumar , Das Rohit Pritam , Panigrahi Lipsa Leena , Arakha Manoranjan
Published: December 2022

Background:

P. aeruginosa, has been frequently connected to immune-compromised
individuals. Dynamic electrochemical metabolite assists in the creation of biofilms, the production
of genes, and the maintenance of bacterial cells. The bacteria produce several phenazine derivatives,
as well as the blue-green pigment pyocyanin, which works as a signalling molecule in quorum
signalling and virulence factors.

Objective:

This review paper intends to give information on the compound's history, virulence
mechanism, current biological horizon opened, as well as antagonism and bio-control actions in
other bacteria. Current industrial trends and the prospects of pyocyanin-based development were
also analysed.

Methods:

A bibliographic search of scientific literature published up to 2020 was conducted using
scientific databases and search engines. Pyocyanin, phenazine, Pseudomonas, virulence, quorum
signalling, health, in vivo, and clinical investigations were among the keywords used in various
combinations. The data were retrieved independently from eligible papers using the usual data
extraction approach.

Results:

Due to pyocyanin's antibacterial properties, the pharmaceutical industry is predicted to
grow faster than other businesses. P. aeruginosa which has had its respiratory chain altered by
protonated 3,5-dichlorophenol in water can be used as a biosensor. Cellular systems exposed to the
chemical experience increased oxidative stress, which leads to gradual apoptosis. Pyocyanin is
engaged in bacterial signalling processes, influencing colony shape and alarming innate immune
cells.

Conclusion:

Focused research on the virulence factor is required, as the specific contribution remains
unknown. The link between biological and therapeutic features needed well description to
determine the precise action mechanism(s) to design novel medications.
Comparative Study of Extremely Low-Frequency Electromagnetic Field,
Radiation, and Temozolomide Administration in Spheroid and Monolayer
Forms of the Glioblastoma Cell Line (T98)
Authors: Yahyapour Rasoul , Khoei Samideh , Kordestani Zeinab , Larizadeh Mohammad Hasan , Jomehzadeh Ali , Amirinejad Maryam , Ahmadi-Zeidabadi Meysam
Published: December 2022

Background:

Glioblastoma is the most common primary malignant tumor of the central
nervous system. The patient's median survival rate is 13.5 months, so it is necessary to explore
new therapeutic approaches.

Objective:

Extremely low-frequency electromagnetic field (EMF) has been explored as a noninvasive
cancer treatment. This study applied the EMF with previous conventional chemoradiotherapy
for glioblastoma.

Methods:

In this study, we evaluated the cytotoxic effects of EMF (50 Hz, 100 G), temozolomide
(TMZ), and radiation (Rad) on gene expression of T98 glioma cell lines in monolayer and spheroid
cell cultures.

Results:

Treatment with Rad and EMF significantly increased apoptosis-related gene expression
compared to the control group in monolayers and spheroids (p<0.001). The expression of
apoptotic-related genes in monolayers was higher than the similar spheroid groups (p<0.001). We
found that treatment with TMZ and EMF could increase the gene expression of the autophagy cascade
markers compared to the control group (p<0.001). Autophagy-related gene expression in
spheroids was higher than in the similar monolayer group (p<0.001). We demonstrated that coadministration
of EMF, TMZ, and Rad significantly reduced cell cycle and drug resistance gene
expression in monolayers and spheroids (p<0.001) compared to the control group.

Conclusion:

The combinational use of TMZ, Rad and, EMF showed the highest antitumor activity
by inducing apoptosis and autophagy signaling pathways and inhibiting cell cycle and drug resistance
gene expression. Furthermore, EMF increased TMZ or radiation efficiency.
Aging, Sleep and Sleepiness Self-Assessment, and the Underlying Drives
for Sleep and Wake
Authors: Putilov Arcady A.
Published: December 2022

In 2016, a mini-issue of Current Aging Science (CAS) entitled “Effects of Aging on
Circadian and Sleep Timing” has been published to report the state of the art in the studies of the
effects of aging on the circadian and sleep regulating processes. The emphasis has been given to
the regulatory processes involved in age-specific problems with sleep timing, continuity, and duration.
Such problems can serve as targets for novel treatments for geriatric and sleep disorders. In
the following 6 years, some new findings provided further insight into the previously recognized
age-specific problems and highlighted new questions of research on the relation of aging to the
regulatory mechanisms underlying circadian rhythmicity, sleep, and sleepiness. The theoretic
framework of one of the directions of this research regards the interaction between the competing
drives for sleep and wake as one of the basic features of regulatory processes underlying circadian
rhythms, including such rhythms as the sleep-wake cycle and the diurnal variation in alertnesssleepiness
levels. Here, earlier and more recently highlighted questions of the research in this
framework were briefly reviewed.
A Systematic Review Study on the Effectiveness of Medicinal Plants
Against Acinetobacter baumannii
Authors: Manouchehri Aliasghar , Marzban Abdolrazagh , Lashgarian Hamed Esmaeil , Alhameedawi Alaa Kamil , Shakib Pegah
Published: December 2022

Introduction:

Acinetobacter baumannii is an opportunistic bacterium capable of causing
nosocomial infections resistant to a wide range of antibiotics. Herbal medicines could become the
source of novel therapies for antibiotic-resistant bacteria. This review paper aimed to survey the effectiveness
of medicinal plants in treating infections caused by A. baumannii.

Methods:

The relevant data was obtained by systematically searching PubMed, ISI Web of Science,
Scopus, Science Direct, and Google Scholar databases with the specific keywords of medicinal plants
(including extracts and essential oils) and bacterial infections (including A. baumannii).

Results:

The present review identified 23 studies published between 2009 and 2021 that discussed the
effectiveness of medicinal plants in inhibiting the growth of A. baumannii. In these studies, 28 medicinal
plants were found effective against infection caused by A. baumannii in vivo.

Conclusion:

The results of this review indicated that to develop a therapeutic strategy for treating bacterial
infections, especially A. baumannii, based on medicinal plants, extensive studies were required
to determine their cytotoxicity and therapeutic dosage before they could be used as an alternative to
antibiotics.
Esophageal Angiodysplasia: A Strange Place for One of Those!
Authors: Sarsour Nadeen Y. , Adejumo Adeyinka C. , Malik Shahid M.
Published: December 2022

Introduction:

Angiodysplasia, also known as angioectasia, is the most common vascular malformation of the gastrointestinal tract, most often found in patients above the age of sixty. Patients with cirrhosis are at increased risk of bleeding and re-bleeding of these lesions. Angiodysplasias can be found throughout the gastrointestinal (GI) tract and are uncommonly found in the esophagus. The recommended treatment for these lesions is Argon Plasma Coagulation (APC); however, there are numerous mechanical and medical strategies that can also be used to treat angiodysplasia.

Case presentation:

This is a case of a 65-year-old woman with decompensated alcoholic cirrhosis and a history of recurrent GI bleeding complicated by hemorrhagic shock presented for anemia. Esophagogastroduodenoscopy (EGD) following her hospitalization was remarkable for bleeding esophageal and gastric angiodysplasias that were successfully treated with APC. The patient returned months later with a recurrent upper GI bleed with EGD, colonoscopy, and video capsule remarkable for angiodysplasias throughout the gastric body, small bowel, and colon without recurrence of the esophageal angiodysplasia.

Conclusion:

The purpose of this case is to demonstrate a rare but possible cause of upper GI bleed in patients with decompensated cirrhosis. While angiodysplasia can occur commonly in the stomach, small bowel, and colon, esophageal angioectasia can occur and contribute to a recurrent GI bleed. These should be considered in the differential diagnosis of upper GI bleed and anemia.
Local Anesthetics and Adjuvants for Labor: Local Anesthetic Systemic Toxicity
Authors: de la Torre Patricia Alfaro , Sacramento Monir Kabiri , Osado Irene Riquelme , García Rosa Fernández
Published: December 2022

The choice of drugs used during labor is almost as important as the analgesic
technique selected since effective pain relief contributes directly to satisfaction: the
better the pain relief, the higher the satisfaction. Although bupivacaine has traditionally
been the most widely used local anesthetic, L-bupivacaine and ropivacaine have similar
action profiles with a lower risk of cardiovascular and neurologic toxicity and
especially less motor blockade, when used under low-concentration strategies. The use
of adjuvants, especially opioids, allows us to improve the analgesic quality while
reducing the total dose of local anesthetics, although their use should be individualized,
and patients should be monitored and treated for side effects if they appear.
Anesthesia for Non-Obstetric Surgery in Pregnancy
Authors: González del Pozo Irene , Vidal Inés Almagro , Agostina Vullo Paula
Published: December 2022

The need for non-obstetric surgery during pregnancy is relatively frequent
and can occur at any time during pregnancy. In this chapter, we will develop the
anesthetic implications of changes in maternal physiology, and the repercussions of
anesthesia on the fetus, and we will delve into the peculiarities of anesthetic
management of these patients. Urgent/emergent procedures should not be postponed in
these patients due to their pregnancy conditions. However, elective surgeries should be
delayed whenever possible, taking into account the maternal-fetal risk-benefit.
Obstetric Hemorrhage
Authors: Flor Robledo María de la , Muñoz Pablo Solís
Published: December 2022

Postpartum hemorrhage (PPH) is the most common cause of obstetric
hemorrhage (OH) and the first cause of maternal death worldwide. However, its
mortality has decreased in the United States in recent decades due to the
implementation of certain measures. Several factors are significantly associated with
the onset of PPH. Identifying them early will help us to establish an appropriate
strategy for the management of these patients. One of the most useful prevention
measures is the active management of the third stage of labor, especially the routine
administration of oxytocin. The existence of acting algorithms will also contribute to a
rapid and orderly response to the presence of expected or unplanned bleeding.
Air and Amniotic Fluid Embolism
Authors: Fernandez Sánchez Clara Isabel , Orozco Vinasco Adriana Carolina , Juan Alvarez Monica San , Castillo Marta Chacón
Published: December 2022

Amniotic fluid embolism (AFE) is an uncommon pathology, whose
incidence ranges from 2 to 8 per 100,000 births, depending on the country. This
syndrome has four cardinal symptoms: circulatory collapse, respiratory distress,
cyanosis and coma. If the patient survives cardiorespiratory failure, disseminated
intravascular coagulopathy occurs, leading to incoercible bleeding and eventually
death. Clinical diagnosis is based on Clark's four criteria: sudden cardiorespiratory
arrest, established disseminated intravascular coagulation prior to bleeding, and all of
these occurring peripartum in the absence of fever. The two main differential diagnosis
syndromes are pulmonary thromboembolism and myocardial infarction. Treatment
consists of cardiopulmonary support of the patient. Despite aggressive measures, such
as the placement of ventricular assist devices and external oxygenation membranes, the
prognosis continues to be poor. The main death cause is incoercible bleeding caused by
disseminated intravascular coagulopathy.
Anesthesia for Assisted Reproduction
Authors: Franco Cabrera Montserrat , Vieyra Cortés Daniel , González Lumbreras Aniza S. , Humberto García Lorant Luis
Published: December 2022

Infertility is a common aspect globally affecting couples to 15%, and it is
frequently increasing the need for anesthesiologists’ participation in assisted
reproductive techniques.
Currently, the procedures used to assist reproduction are unable to fully cover the
detrimental effects of age. During anesthesia-analgesia in oocyte retrieval, the role of
the anesthesiologist is to provide the patient with adequate anxiolysis, analgesia, and
sedation as the key to success in the procedure. An adequate pre-anesthetic assessment
is required to identify derivative diseases and take the appropriate care of each patient.
Modern anesthetic techniques for oocyte retrieval include conscious sedation, general
anesthesia, regional anesthesia, and other alternative techniques, such as
electroacupuncture, or even a combination of these.
In this chapter, the main characteristics of these techniques will be exposed, as well as
their complications and the recommendations so that anesthetic procedures are safe not
only for the patient, but also for the whole process’ success.
Applications of Ion Exchange Resins in Vitamins Separation and Purification
Authors: Saha S.
Published: December 2022

Vitamins are vital compounds for the improved development and growth of the human body system. Together chemically and analytically, vitamins are divergent assembly of composites as they comprise of biomolecules. The source of vitamins is the necessary dietary food stuff. Small amounts of vitamins are needed to sustain a healthy life. Vitamins are generally classified into fat-soluble and water-soluble vitamins. The major portions of vitamins are vitamin A, vitamin B, vitamin C, vitamin E and vitamin K. This chapter discussed diverse procedures for the partition and purgation of vitamins B, C and K through several ion exchange resins.
Separation and Purification of Bioactive Molecules by Ion Exchange
Authors: Alam R.
Published: December 2022

Bioactive molecules (or signaling molecules) are involved in tissue regeneration and have an important role in modulating the microenvironment in vivo. Bioactive chemicals have the ability to govern host cell motility, proliferation, and differentiation, as well as enabling cells to interact with their surrounding microenvironment via particular receptors for chemical recognition. This chapter introduces ion-exchange chromatography (IEC) as a method for separating and purifying bioactive compounds such as polyphenols, catechin derivatives from complicated plant mixtures, proteins, minor whey protein, peptides, human C-peptide, alkaloids from Chinese medicines, plasmid DNA and carbohydrates.
Ion Exchange Resins as Carriers for Sustained Drug Release
Authors: Kumar B.S.
Published: December 2022

Ion exchange resins are water-insoluble cross-linked polymers conventionally used in chemical engineering to separate and purify substances from fluid mixtures and for the separation of gases. They are used in the pharmaceutical industry as a carrier for controlled drug delivery systems. Sustained drug release involves the release of the drug at a predetermined rate into the target system and helps maintain a constant drug concentration for a specified period. At present ion-exchange resins are widely studied and used as drug-delivery agents. Ion-exchange fibers are shought as an alternative due to their better efficiency in drug loading and delivery.
Ion Exchange Resins for Clinical Applications
Authors: Sarfraz M.H.
Published: December 2022

Ion exchange resins are the cross-linked polymers that are insoluble in water and consist of charged ionic groups, for exchanging counter-ions, at repeating positions along the resin. IERs are majorly classified into two types i.e., cationic exchange resins and anionic exchange resins, depending on the type of ion exchanged. Over the last few years, ion exchange resins have gained significant attention owing to their various benefits in drug formulations improving the taste, stability, anti-deliquescence, and dissolution of the drug. They also play a role in targeted drug delivery via employing various delivery technologies such as sigmoidal release system, gastric retentive system, hollow fiber system and microencapsulated resonates. Furthermore, they are also used for therapeutic purposes like treating different ailments and abnormalities such as treating high cholesterol, edema, pruritus, cardiac edema, uremia etc. The chapter presents an overview of the role of ion exchange resins in various clinical implications.
The Boron Arsenides
Authors: Fisher David
Published: December 2022

Boron Arsenide offers very interesting electronic properties, as well as a high thermal conductivity; nearly 10 times higher than that of silicon. It has been hailed as ‘the best semiconductor material ever found’. The present book presents a detailed review of this material and its potential applications. The materials covered include Icosahedral Boron Arsenide, Hexagonal Boron Arsenide, Amorphous Boron Arsenide and Cubic Boron Arsenide. The book references 166 original resources with their direct web links for in-depth reading.
Digitalizing Governance in South Sumatera: An Introduction “E-Sumsel” System Reforming Public Service Management
Authors: Mislawaty Sri Eva , Harahap Raegen , Anisyah Siti
Published: December 2022

Digitizing government by utilizing the Internet, Communication, and Technology (ICT) is one of the biggest focuses on innovative actions and reforms through various instruments towards improving the quality of public service outcomes. This research discussed the governmental innovation and reform in the South Sumatera Provincial government, which has been trying to increase and improve governmental working transparency and accountability, public management system, and public service improvements known as “E-Sumsel.” By employing qualitative methods, the data collected and extracted from library research such as books, journals as well as the internet. Based on the result, it was found that “E-Sumsel” programs were established to shape digitalizing public management system and for democratic public service transparency and accountability. By focusing on transformations, the South Sumatera provincial government established “E-Sumsel” programs for showing any information about the information such as business opportunities, as well as about the government working. Meanwhile, it has identified several challenges in establishing “E-Sumsel” programs in the South Sumatera government, which remains high-incidence fiefdoms and a strong vertical orientation conspicuous among the governmental agencies. It needs further development to be resolved by creating a new innovative strategy to harmonize the provincial governmental standard operating systems in improving quality public management and public service. For this reason, innovative government action through “E-Sumsel” is very important mode to exist continuously in administrative reform in government institutions with governance innovation that influences each other.
The Role of Dietary Pattern in Moderating the Association Between Social Isolation and Frailty among Chinese Older Adults: National Cross-sectional Study (Preprint)
Authors: Pei Zhongfei , Qin Wenzhe , Zhang Jiajun , Hu Fangfang , Xu Lingzhong , Wu Shoucai
Published: December 2022

BACKGROUND

Frailty is a health problem that is extremely prone to arise with aging and is more prevalent in socially isolated older adults. The dietary pattern often serves as an important determinant of health in later life that cannot be ignored. Identifying the role that a specific dietary pattern plays in social isolation and frailty can provide insights to improve the quality of life of older adults.

OBJECTIVE

This study aims to determine the relationship between social isolation and frailty and investigate whether a specific dietary pattern moderated this association among Chinese older adults.

METHODS

This cross-sectional study used data from the eighth wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2018. A total of 8889 older adults (aged 60+) were included in our study. Frailty was assessed using FRAIL Scale. Social isolation was defined by marital status, living arrangement, frequent visit by family members, and social participation. Dietary patterns were explored by principal component analysis. The logistic regression was used to carry out the moderating effect analysis.

RESULTS

Four dietary patterns were identified, namely “vegetable-nut-mushroom or alga”, “egg-milk”, “meat-fish”, and “pickle”. Subjects with higher levels of social isolation were associated with a higher risk of frailty (OR=2.31, 95%CI=2.17-2.46). We observed that the egg-milk pattern as a moderator alleviated this relationship (OR=0.91, 95%CI=0.86-0.97).

CONCLUSIONS

Our study suggested that social isolation was positively correlated with frailty and the egg-milk pattern is a moderator in this relationship. Improving the social isolation of older people was beneficial to prevent frailty. It is necessary to advocate the dietary pattern characterized by eggs and milk in socially isolated older adults to reduce the risk of frailty.
Rancang Bangun Monitoring Kadar Gas Metana pada Pengolahan Sampah Organik Berbasis IoT Menggunakan Mikrokontroler ESP32
Authors: Novantri Salma Osa , Oktiawati Unan Yusmaniar
Published: December 2022

Abstract –The accumulation of waste, especially organic trash, can cause respiratory distress. It also can even cause explosions. The explosion was caused by organic trash containing methane gas with certain levels reacting with free air. To create a clean and healthy environment from trash needs, every household should be further handles them, specifically with utilizing organic trash as a basic fertilizer. This tool is intended to help problems caused by the onset of methane gas in the process of processing organic trash. It can detect methane gas concentrations using MQ-4 sensors in ppm units and supported by DHT-22 sensors to detect air temperature and humidity in dust bin. The process of monitoring and processing data is conducted by ESP32 microcontroller connected to a website through internet in accordance with the principles of IoT (internet of things) through the media website.Keywords: organic trash, methane gas level, monitoring, MQ-4, IoTIntisari–Penumpukan sampah khususnya sampah organik dapat menyebabkan gangguan pernapasan bahkan dapat menimbulkan ledakan. Ledakan tersebut disebabkan karena sampah organik mengandung gas metana dengan kadar tertentu bereaksi dengan udara bebas. Dalam rangka menciptakan lingkungan yang bersih dan sehat dari sampah perlu ditindak lanjuti dengan penanganan sampah secara mandiri di setiap rumah tangga yaitu dengan memanfaatkan sampah organik sebagai pupuk dasar. Alat ini dimaksudkan untuk membantu permasalahan yang disebabkan oleh timbulnya gas metana pada proses pengolahan sampah organik. Alat ini dapat mendeteksi konsentrasi gas metana menggunakan sensor MQ-4 dalam satuan ppm dan didukung dengan sensor DHT22 untuk mendeteksi suhu dan kelembaban udara dalam tong sampah. Proses pemantauan dan pengolahan data didukung oleh microcontroller ESP32 dengan jaringan internet sesuai dengan prinsip IoT (internet of things) melalui media website.Kata kunci: sampah organik, kadar gas metana, monitoring, MQ-4, IoT
Crisis Management: Examine the influence of successful Leadership Styles on Crisis Management
Authors: Othman Baban Jabbar , Rashad Muhammed Khazal , Kanabi Idrees Sadeq , Jamil Diyar Abdulmajeed , Mahmood Rozhgar Khorsheed , Ismail Zaid Saad , Jwmaa Swran Jawamir , Younus Saif Qudama
Published: December 2022

The primary purpose of this research is to investigate the connection that exists between different types of leadership and how well private companies in Erbil deal with times of crisis. In order to accomplish the objectives of this research project, a quantitative approach was used. Six hundred thirty individuals responded to the survey, making the total number of participants. According to the findings, charismatic leadership proved to be the most valuable of all the other forms of leadership. According to the findings of the study, charismatic leadership has been subjected to increased scrutiny over the past few decades, and the growth plans of businesses typically require revision while facing a crisis. The findings of the current study will serve as a guide for government agencies, notably private firms in Erbil, in the process of selecting individuals who are capable of charismatic leadership in times of crisis.
The Effect of Blended Learning Instruction using Simplified Science Module on Students’ Academic Performance
Authors: Leon Florhen B. De , L. Matolo Mona-Allea
Published: December 2022

In the new normal set-up, one of the ideal modes of teaching and learning used in the K-12 curriculum that is engaging and motivating is blended learning instruction. This study focused on the effect of blended learning instruction using simplified science module on the academic performance of Grade 11 students of Tawi-Tawi School of Arts and Trades (TTSAT) and Tawi-Tawi School of Fisheries (TTSF). This study made use of quasi-experimental design and had two sets of research instruments: the simplified science module used in blended learning instruction and the Pre-test and Post-test Questionnaire. The result revealed that there was an increase in the level of academic performance of students in both schools with blended learning instruction using simplified science module. It also revealed that blended learning instruction using simplified science module exhibits large effect in content standards such as Stellar Formation and Origin of Elements, Atomic Concept, and Chemical Reaction while medium effect on Properties of matter and Its Chemical Structure. There is a significant difference on the level of performance from pre-test to post-test of the said students in both schools. There is no significant difference on the extent of effect of blended learning instruction using simplified science module on the academic performance of the concerned students in both schools along the four content standards. Consequently, blended learning instruction using simplified science module is an effective way of engaging and motivating students to learn in both schools. Thus, schools should encourage teachers to engage students in blended learning instruction to achieve effective and meaningful learning.
The Effect of Phubbing on the Decrease in the Value of Student Social Solidarity in the Millennial Era (An Environment Because It Focuses More on Gadgets)
Authors: Adripen Adripen , Afrina Cut
Published: December 2022

The purpose of this study was to determine the effect of phubbing on the decline in the value of student social solidarity in the millennial era (an environment because it is more focused on gadgets) in library and information science students at UIN Ar-Raniry Banda Aceh. This research uses quantitative research methods. The research variable consists of one independent variable, namely: Phubbbing (X) and the binding variable, namely: a decrease in the value of student Social Solidarity in the Millennial era (Y). The sampling technique used was technique sampling with a total of 111 students, while the samples were 87 students. Based on the results of the descriptive analysis test using the mean formula and the results of the derivative of the grand mean of the variable (X), it is categorized well with a mean value of 3.2. While the variable (Y) is categorized as good with an average value of 2.89. The result of the product moment correlation test, that the large correlation coefficient between variable (X) and variable (Y) obtained a result of 0.711, the coefficient interval between 0.80-1000 shows a very strong influence, where the direction of the influence is positive because the R value shows a number positive. The simple regression results for variable (X) and variable (Y) Y = 10.553 + 0, 802X and R Square for 0.711 means that the effect of variable (X) with variable (Y) is 52.20%. Other factors outside this study amounted to 48.80%.
Genealogy of Conflict among Bone and Luwu Students in Makassar City
Authors: Tamrin Sopian -
Published: December 2022

The phenomenon of conflict among students that have occurred recently raises several questions. Is this conflict in accordance with the specific factors of each case or has certain socio-cultural roots. If that so, why do conflicts occur more often against certain areas. Why does the conflict always recur even though reconciliation has been carried out every time the conflict occurs. This research has some purposes: firstly, finding out the social and cultural roots of conflict among Bone and Luwu students. Secondly; finding how to handle regional conflicts among students. This research is descriptive qualitative by using knowledge geneaology approach from Michel Foucault. Research data obtained through observation, in-depth interviews and documentations. The results showed that a) the phenomenon of conflict among Bone and Luwu students had socio-cultural roots that were produced in the form of internal knowledge from generation to generation. The birth of the local organization of commissariat on campus marked a period of significant discontinuity producing inter-regional conflict. In addition, the functional of regional organizations as regeneration spaces that perpetuate fanaticism; b) regional organizations need to encourage an inclusive regeneration curriculum. In addition, it is very important to carry out social and spatial engineering that allows inclusive activities to live on campus by strengthening student institutions.
Changes in Cultural Values of Ma'pasilaga Tedong (Case Study on Death Services in Lembang Sarambu, Buntu Pepasan District, North Toraja Regency
Authors: Kerebungu Ferdinand , Santie Yoseph D. A. , Fathimah Siti , Sulle Risma
Published: December 2022

This paper describes the socio-cultural changes that occur in the Lembang Sarambu community, Buntu Pepasan District, North Toraja, in the ma'pasilaga tedong tradition, along with the factors that influence the occurrence of these social changes. The method used in this research is the descriptive qualitative method, with data collection techniques of observation, interviews, and documentation. The results in this study are the values contained in the ma'pasilaga tedong tradition, namely 1) cultural values, ma'pasilaga tedong is a tradition that has been passed down from generation to generation to perfect the implementation of the rambu solo ceremony; 2) the value of customs, the Toraja people believe that the buffalo is a sacred animal; 3) moral values, in the ma'pasilaga tedong tradition, the buffalo that will be competed are buffalo that have certain criteria, such as the buffalo that will be competed must be the buffalo that will be sacrificed for the corpse; 4) social values, namely the tradition of ma'pasilaga tedong cannot be carried out if there is no solo sign ceremony'. The values that have changed in the ma'pasilaga tedong tradition are: 1) moral values, where the ma'pasilaga tedong tradition which originally aimed to comfort the bereaved family and as a form of empathy for the bereaved family has now become a gambling arena for ma'pasilaga tedong ; 2) and the initial social value of ma'pasilaga tedong was only done in one day, namely when there was a rambu solo' ceremony, but now it has been carried out for days even though the rambu solo' ceremony is not held. With the factor of cultural changes that occur caused by internal factors; population and discoveries and external factors; war and other cultural influences.
SOCIAL PRACTICE OF SEXUAL VIOLENCE IN SOCIETY (CASE STUDY IN PADANG CITY)
Authors: Maihasni Maihasni , Fachrina Fachrina , Anggraini Nini
Published: December 2022

There is not a day without sexual violence to children in mass media. Some people think that Indonesia has  emergency case of sexual violence. Padang city is belong to this phenomena, such as 5 students of elementary school were victims of sexual harassment by a sports teacher, sexual harassment in public transportation, sodomy of 3 students, rape of a disabled woman by her brother-in-law, and rape by her stepfather, parking attendant and employer. The worst case is a sexual harassment by legislative candidate in 2018 and 2 bilogical children by their father in 2020. Government and non-Governmental institutions have been doing many efforts to prevent and cope of sexual violence.  However, cases still happen.  For this reason, the study tried to analyze why sexual violence still occurs even though various efforts have been made. The study used a qualitative approach with a descriptive type. The selection of informants used purposive sampling. Data collection used  depth interviews and literature review. The results found that  sexual violence occurs in girls under the age of 12 years. The actors are dominated by the closest people such as father, siblings, uncles, teachers, neighbors and a official. The encourage factors of sexual violence in the community are related to the mentality of the perpetrator, powerlessness of the victim, lack of communication and social control of parents, lack of religious knowledge, pornography and poverty. Meanwhile, the disencourage factors of sexual violence itself, such as; sex education, doing positive activities, social control and sanctions and severe punishment for perpetrator.
Minangkabau Local Wisdom In Marosok Tradition
Authors: Siska Felia , Sapriya Sapriya , Supriatna Nana , Ratmaningsih Neiny
Published: December 2022

The Minangkabau community has various types of unique and distinctive local wisdom. However, with the times, local wisdom is not widely known by the public, especially the younger generation. The marosok tradition in the cattle market is a form of unique Minangkabau local wisdom and is a Minangkabau cultural identity that is full of life values. The purpose of this study is to identify the values of local wisdom in the marosok tradition. This study uses descriptive qualitative research methods. Data collection techniques are interviews, observations, and interviews. The informants of this research are livestock traders, managers, and students of MTsN Palangki. Data analysis techniques are data reduction, data verification, and drawing conclusions. The results show that Minangkabau local wisdom in the marosok tradition is based on the philosophy of "Alam Takambang Jadi Guru". The sale and purchase transaction of livestock using the marosok system which is preserved from generation to generation aims to prioritize mutual benefits, mutual respect, raso jo pareso. This tradition contains entrepreneurial character values, namely hard work, responsibility, persistence, ingenuity, and honesty. This tradition is preserved: 1). culture experience, direct experience in the field, livestock traders teach their children and nephews 2). Culture knowledge, namely introducing this tradition through socialization to the younger generation, film media, cultural tourism, and other traditional activities. So, it can be concluded that the marosok tradition is a characteristic and as a Minangkabau cultural identity that must be preserved through learning in schools.
Estimation of Carbon and Biomass Trees Outside Forest (Tof) Using Remote Sensing and GIS Case Study in Vikarabad District, Telangana State India
Authors: Srinu Sabavath
Published: December 2022

Abstract: Geospatial technology, remote sensing (RS), geographic information system (GIS), and global positioning system (GPS), commonly called the three 'S' systems, and field inventory methods with hyper spectral sensors play a major role in developing effective forest information. Management to realize scientific management of system forest resources ,Non-forest trees play an important role in global carbon cycling, as they are large pools of carbon as well as potential carbon sinks and atmospheric sources. Given the importance of biomass estimates in the global carbon (C) cycle, the present study demonstrates the potential of stand wise trees outside of forest inventory data, and we specifically used Cartosat-1 panchromatic (2.5 m) and multispectral. LISS-IV (5.8 m) dataset to quantify vegetation and create a much-needed database for TOF. The total geographical study area of Vikarabad district is 104903 sq.km. Results will help address key ecosystem services in the TOF, including quantifying greenhouse gas emissions from agriculture, forests and other land use categories. What is different from the above TOF biomass is that the TOF biomass averaged 2150.12 t/ha in all three classes linear, polygonal and scattered. Total TOF biomass and carbon content above ground were calculated as 24.43 t/ha, 414.46 t/ha and 556.36 t/ha respectively in the study area. The results of the study conclude that classification of TOF and prediction of biomass and carbon content in TOF can be successful. Achieved through a combined approach of remote sensing and GIS based spatial techniques with supplement of field data. The current approach would help to find potential carbon sequestration area in Vikarabad District Telangana State India
MÜZİK ÖĞRETMENLİĞİ ÖZEL YETENEK SINAVLARINA BAŞVURAN ADAYLARIN YERLEŞTİRME PUANLARI İLE SOSYO-DEMOGRAFİK ÖZELLİKLERİNİN KARŞILAŞTIRILMASI
Authors: TANKIZ K. Dilek , ARAPGİRLİOĞLU Hasan
Published: December 2022

Bu araştırma, İnönü Üniversitesi Eğitim Fakültesi Güzel Sanatlar Eğitimi Müzik Öğretmenliği Programına başvuran adayların, sosyo-demografik nitelikteki özellikleri ile yerleştirme puanları arasındaki ilişkiyi tespit etme amacını taşımaktadır. Araştırmanın çalışma grubunu 2010-2011 Eğitim Öğretim yılı özel yetenek sınavına başvuran 387 aday oluşturmaktadır. Adayların sosyo-demografik nitelikteki özellikleri; Cinsiyet, mezun olunan lise türü, yaşantının çoğunun geçirildiği yer-bölge, anne-baba eğitim durumu, aile aylık gelir (varsa adayın geliri de dahil), aile müzik ilgi durumu, özel yetenek sınavlarına hazırlık süresi ve hazırlanma biçimleri, hazırlık süreci dışında müzik eğitimi alma durumu, sınavda performans gösterdiği çalgı alanı değişkenlerine göre yerleştirme puanları incelenmiştir. Elde edilen verilerin hesaplanmasında Kruskal-Wallis H testi, Mann-Whitney U testi, t-testi, tek yönlü varyans analizi (ANOVA) ve Tukey testi kullanılmıştır. Çalışmanın sonucunda, adayların sosyo demografik nitelikteki özellikleri ile yerleştirme puanları arasındaki anlamlılık durumlarına ilişkin sonuçlar açıklanmıştır.
A Case Report on Multiple Adverse Events Associated with Systemic Usage of Dexamethasone
Authors: Poludasari Shravan Kumar , Sridevi CH.
Published: December 2022

Dexamethasone is a corticosteroid used in the management of various allergic conditions, inflammatory and autoimmune disorders such as rheumatoid arthritis, nausea and vomiting associated with cancer chemotherapy, multiple sclerosis, cerebral edema. ADRs associated usage of corticosteroids includes steroid-induced hyperglycemia, osteoporosis, dyslipidemia, steroid-induced Cushing syndrome, cataracts, increased risk of infections, and thinning of the skin. Cushing's syndrome is a hormonal disorder triggered due to chronic exposure of body tissues to high levels of cortisol. As corticosteroids are widely used by physicians for the management of various inflammatory disorders, patients must be warned about the possible ADRs associated with chronic use. In summary, this is a case of a patient who developed multiple adverse events after usage of dexamethasone that is evident by clinical features and laboratory investigations for which the patient was successfully provided with symptomatic and supportive care.

Keywords: Adverse Drug Reaction (ADR), Buffalo hump, Hyperglycaemia, Osteoporosis.
Beta blockers in HF, reduced EF And Increased HR
Authors: S A Arya Babu , John Ajo
Published: December 2022

Care for cardiac patient has been revolutionized throughout the past decades. Despite its initiated safety concerns, beta blockers are now one of the most used and safer drugs for the ailment of heart failure. These have proved not only  effective for heart failure but also for many other conditions such as migraine headaches, breast cancer to reduce the mortality etc.

Keywords: beta blockers, heart failure with reduced ejection fraction, heart rate
Insulin initiation in Type 2 diabetes mellitus outpatients – data from the multicentre evaluation of type 2 diabetes mellitus outpatients on insulin therapy in Nigeria (METOIN study)
Authors: Nkpozi Marcellinus O , Bozimo GE , Ubani BC , Owolabi FA , Akhidue K , Ezeude CM , Ogbonna SU
Published: December 2022

People living with type 2 diabetes mellitus (T2DM) have relative insulin deficiency and, therefore, have options to insulin therapy. To be on insulin alone or in combination with other therapies in type 2 DM outpatients is a choice made personalized for each patient. Published literature on the insulin initiation patterns among T2DM outpatients in Nigeria is scanty. The objective of this study, therefore, is to bridge this gap in knowledge. This was a prospective cross sectional study conducted in five tertiary health facilities in Nigeria in which consenting type 2 DM outpatients on insulin therapy alone or in combination with other therapies and who meet the inclusion criteria for the study were recruited. Relevant data relating to insulin use initiation by the patients were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. A total of 268 outpatients living with type 2 DM on insulin therapy, made up of 116 (43.3%) male and 152 (56.7%) females participated in the study. Only 55 (20.5%) of the patients started insulin at onset of diagnosis of T2DM while 46 (17.2%) of the patients started insulin therapy after 5 years of living with T2DM. The duration of living with DM before insulin initiation and the patient's highest level of education were not statistically significant. Insulin initiation was delayed several months to years after diagnosis of T2DM by predominantly endocrinologists in tertiary health facilities but it was initiated in 19 (7.1%) of the T2DM outpatients by primary care physicians (GPs) in peripheral hospitals. It is recommended that diabetes education be intensified for T2DM patients to appreciate the key role of insulin therapy in diabetes care.

Keywords: insulin initiation, type 2 diabetes mellitus outpatients, Nigeria.
Pārdomas par sargāšanu: Āraišu konteksts
Authors: Melluma Aija
Published: December 2022

Mantojuma jēdziens dažādiem tiesiski normētiem aizsardzības nosacījumiem piešķir cilvēcisko dimensiju, jo mantojums nozīmē paaudžu saikni, arī pašreizējo paaudžu atbildību
Modes ietekme 18. gadsimta otrās puses un 19. gadsimta sākuma Vidzemes sieviešu tradicionālajā apģērbā: krāsu aspekts
Authors: Karlsone Anete
Published: December 2022

Raksts sniedz ieskatu 18. gadsimta Vidzemes sieviešu tradicionālā apģērba vēstures pētniecībā, pievēršot uzmanību augšslāņu modē aktuālo krāsu izmantojumam arī zemnieku apģērbā. Analizējot 18. gadsimta beigu zemnieku apģērba zīmējumus, kā arī 18.–20. gadsimta rakstītos avotus, mēģināts skaidrot melnu, vienkrāsainu sieviešu svārku jeb brunču un dzeltenu priekšautu valkāšanas tradīciju Vidzemē, tās izplatības hronoloģisko un teritoriālo ietvaru, kā arī šo krāsu iegūšanas tehnoloģiju un saikni ar modes ietekmēm. Veiktie pētījumi apliecina, ka laikā no 18. gadsimta 60. gadiem līdz 19. gadsimta 20. gadu beigām plašā Vidzemes apvidū pie goda tērpa likti dzelteni priekšauti. Tie valkāti kopā ar melniem, vienkrāsainiem brunčiem, kuru teritoriālā un hronoloģiskā izplatība bijusi plašāka nekā minētajiem priekšautiem. Pētāmajā laika periodā Vidzemes zemnieku apģērbā augstāko aprindu modes ietekme izpaudās kā noteiktu krāsu izmantojums, kas nenoliedz arī citu laikmetīgās modes iezīmju pastāvēšanu. Dzeltenā un melnā krāsa saistāma ar atšķirīgiem modes stilu strāvojumiem, no kuriem zemnieciskajā vidē tika pārņemtas atsevišķas to vizuālās izpausmes. Krāsošanas eksperimenti pierādīja augstu ticamības pakāpi rakstītajos avotos minētajām ziņām par konkrētiem 18. gadsimtā lietotajiem krāsaugiem un no tiem iegūstamajiem krāsu toņiem. Vienkrāsainie melnie Vidzemes sieviešu svārki un dzeltenie priekšauti ir uzskatāmi par atbilstošiem minētā laika perioda tradicionālajam zemnieku goda tērpam, lai arī šie priekšmeti līdz mūsdienām nav saglabājušies.
Pola Komunikasi Komunitas Virtual ICB dalam Meminimalisasi Hoaks
Authors: Rahmat Giyan Rahmat
Published: December 2022

The purpose of this study is to describe ICB's communication pattern as a virtual community in an effort to minimize hoaxes. This is caused by ICB's position as a massive virtual community that uses Facebook as its communication medium. However, Facebook as a social media is a place for networking information with a wide range, so that it also allows the emergence of hoaxes in circulating information. This research used a descriptive qualitative method with data collection through observation, in-depth interviews, and documentation. This research finds that there are two models of communication patterns used by ICB, namely: the wheel communication pattern and the all-channel communication pattern. The wheel communication pattern includes filtering of uploaded information within the group, in which each member waits for approval from the admin to join or share uploads to the group, especially with a centralized flow at one point, so that the flow of incoming information is orderly and minimizes hoaxes within the group. Meanwhile, the communication patterns of all channels allow for more flexible community meetings and activities, in which each member can interact with anyone without any restrictions.
Sharp threshold of global existence and mass concentration for the Schrödinger-Hartree equation with anisotropic harmonic confinement
Authors: Jian Hui , Gong Min
Published: December 2022

This article is concerned with the initial-value problem of a
Schrödinger-Hartree equation in the presence of anisotropic
partial/whole harmonic confinement. Firstly, we get a sharp threshold
for global existence and finite time blow-up at the ground state mass in
the L 2 -critical case. Then, some new cross-invariant manifolds and
variational problems are constructed to study blow-up versus global
well-posedness criteria in the L 2 -critical and L 2 -supercritical
cases. Finally, we research the mass concentration phenomenon of blow-up
solutions and the dynamics of the L 2 -minimal blow-up solutions in the
L 2 -critical case. The main ingredients of the proofs are the
variational characterization of the ground state, a suitable refined
compactness lemma and scaling techniques. Our conclusions extend and
compensate for some previous results.