bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementación de controles tecnológicos para la Mejora Continua en la reducción de accidentes en la construcción de piques
Authors: Berrocal Argumedo Kelvis
Published: January 2022

El presente estudio tiene como objetivo general determinar el efecto de la implementación de los controles tecnológicos para la Mejora Continua en la reducción de accidentes en la construcción de piques - Corporación Minera Géminis SAC.

El estudio se basa en el análisis estadístico de los índices de accidentabilidad y las medidas de control: geotécnicas, administrativas y de seguridad propiamente dicha, así como la participación responsable, comprometida y apropiada en el desarrollo y optimización de la seguridad mediante el control, principalmente tecnológico para reducir los accidentes, como se ha comprobado entre los años 2010 al 2017.

Están definidas las variables del estudio y son analizadas de forma exhaustiva para determinar la relación que existe desde una perspectiva principalmente cuantitativa que permite una mejor apreciación de los efectos.

Finalmente, se consideran conclusiones que manifiestan la intención de la investigación, y se proponen algunas sugerencias para el mejor control de la seguridad.
Algoritmo basado en Árboles de decisiones para la predicción óptima del Sistema Pensionario Peruano: Revisión sistemática de la literatura
Authors: Ogosi Auqui José Antonio , Romero Echevarría Luis Miguel , Mayhuasca Guerra Jorge Víctor
Published: January 2022

En el presente artículo se ha desarrollado teniendo en cuenta las directrices para la Revisión Sistemática de la Literatura (SLR), se centra en lo fundamental que es la elección de un seguro de pensiones, teniendo en cuenta que existen dos tipos sistemas: El Sistema Privado de Pensiones (AFP), en el que el trabajador recibe lo que ha cobrado a lo largo del período que ha trabajado como una cuenta de ahorro personal; y el Seguro Nacional de Pensiones (ONP), que es un organismo público que asigna el dinero aportado por los trabajadores (fondo común) y se desembolsa como concepto de pensiones a los jubilados. Teniendo en cuenta el problema de la falta de información sobre el Seguro de Pensiones que brindan tanto las entidades públicas como privadas, se decidió construir un algoritmo de árbol decisión para de acuerdo a una cierta información brindada se pueda lograr una toma de decisiones relevante para cada trabajador que acceda a planilla por primera vez o para aquellas personas que trabajan de forma independiente, ya que esta decisión será fundamental para la futura estabilidad económica del trabajador.
Forzamiento radiativo directo debido a los aerosoles atmosféricos en Perú utilizando técnicas de sensoramiento remoto
Authors: Angeles Vasquez Roberto Julio , Angeles Suazo Julio Miguel , Suazo Nataly , Lozano Arlitt , Flores Rojas Jose , Abi Karam Hugo
Published: January 2022

Describimos los resultados del estudio del espesor óptico de aerosol (EOA) y el Forzamiento Radiativo Directo (FRD) en la cima de la atmósfera (TOA), obtenidos en el periodo 2004 utilizando el sensor MODIS del satélite TERRA para Perú. Donde se observa que el valor del EOA puede tomar valores máximos alrededor de 0.5, obteniéndose como resultado el FRD de aerosol en la parte superior de la atmósfera. Los resultados indican que, la FRD está entre [-5 0] W / m2.
Uji Skrining Fitokimia Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea Batatas L.)
Authors: Lidyawati Lidyawati , Dita Sasmiati Farach , Agustiany Cut Melly
Published: January 2022

Purple sweet potato leaf (Ipomoea batatas L.) is one of the plants that has begun to be used as a traditional or herbal medicine. This study aims to determine the content of secondary metabolites from purple sweet potato leaves. This research was conducted at the Chemistry Laboratory, Faculty of Tarbiyah, State Islamic University of Ar-Raniry Banda Aceh with laboratory testing methods. Purple sweet potato leaves were extracted by maceration using 5 L 96% ethanol for 5 days and evaporated in a vacuum rotary evaporator to form a thick extract. Furthermore, phytochemical screening tests were carried out. The test results stated that purple sweet potato leaf extract contains Alkaloids (+++), Flavonoids (+), Tannins (+), Saponins (+), Terpenoids (+), and Steroids (+).
Formulasi Dan Evaluasi Fisik Sediaan Gel Antiseptik Tangan Dari Ekstrak Etanol 96% Daun Pandan Wangi (Pandanus Amaryllifolius Roxb)
Authors: Putri Rahmawida
Published: January 2022

Antiseptic serves to kill or inhibit the growth of bacteria that can cause the onset of disease. Antiseptics can be formulated with natural ingredients so that they are environmentally friendly. Pandan wangi leaf is a plant that is often used as a food additive leaves, as a green dye and aroma. Pandan fragrance is also one of the plants that can be used as antiseptic formulations because it has antibacterial activity and can be used as a topical preparation in the form of gels. The aim of this research is to know the difference of pandan wangi leaf extract concentration (Pandanus amaryllifolius Roxb.) Which has optimum physical properties evaluation. This research is an experimental research, maseration method used to get extract with 96% ethanol. The gel was formulated into four formulas with various extract concentrations of 10%, 20%, 30%, and 40%. Evaluation tests include: organoleptic, homogeneity, pH, dispersion, viscosity, stability, hedonic, irritation and hand antiseptic testing. The results showed that the concentration of extract had no effect on pH and homogeneity. Increased concentration of extract effect on the color change and aroma. The higher concentration of extract will be more concentrated also color. The result of stability inspection showed that texture change in F2 and aroma change in F3. A good gel preparation formula based on physical quality and hedonic test is a concentration formula of 10% (F1).

Keywords: Pandanus amaryllifolius Roxb., Hand Antiseptic, Gel.
Aktivitas Antibakteri Ekstrak Etanol Daun Bandotan (Ageratum Conyzoides L.) Terhadap Bakteri Streptococcus Pyogenes
Authors: Putri Rahmawida , Fhatonah Nuriyatul
Published: January 2022

The treatment of bacterial infectious diseases using a semi synthetic antibiotic can lead to resistance, so that the search is necessary to overcome it the ingredients of natural medicine from plants, one of them namely bandotan leaf extract (Ageratum conyzoides l.). This research aims to identify the chemical compounds contained in leaf bandotan and knowing his activity as antibacterial against Pseudomonas aeruginosa and s. pyogenes. The leaves are extracted in bandotan maceration using solvent ethanol 96%. The extract was tested using the method of antibacterial activity of sumuran and clear zones are measured that is formed using a caliper and triplo. The results of the identification of a compound leaf bandotan secondary metabolite showed a group of compounds alkaloids, saponins, tannins, flavonoids, phenolic, triterpenoid glycosides, steroids,. Based on a test of antibacterial activity against s. pyogenes with the concentration of 100%, 50%, 25%, 12.5%, 6.25% showed a clear zone on the concentration in a row with an average of 14.52 mm; 13.87 mm; 13.38 mm; 12.38 mm; 11.75 mm; 15.33 mm. While testing the antibacterial activity against Pseudomonas aeruginosa with the same concentrations did not show the presence of antibacterial activity of extracts of leaves of bandotan with no clear zone formation
Evaluation of Drug Use at Pasar Merah Public Health Center in Medan
Authors: Ismedsyah Ismedsyah , Takarina Takarina
Published: January 2022

Evaluation of drug use is one of the clinical pharmacy services at Public Health Center. Evaluation of the drugs use must refer to the indicators of drug use.This study aimed to determine the average number of drugs in each prescription, the percentage of prescribed generic drugs, the percentage of prescribed antibiotics, the percentage of injection, and the percentage of drugs prescribed from the DOEN (List of National Essential Medicines) at Pasar Merah Public Health Center Medan. This research was a retrospective descriptive study carried out by collecting data from the available documents as well as interviews with the head of Medan Pasar Merah Public Health Center and drug management officers.Through the research, it was found that the average number of drugs in each prescription was still high, not in accordance with the prescribed standards, the percentage of generic drugs prescribed was not good, the percentage of prescribed antibiotics was quite high, the percentage of injections prescribed did not meet the percentage indicator of injection prescription, and the percentage of drugs prescribed from the DOEN at Pasar Merah Medan Public Health Center was quite good. This study concludes that the use of drugs in Pasar Merah Medan Public Health Center has not met the indicator of drug use
Formulasi Sediaan Hand Body Lotion Menggunakan Ekstrak Etanol Daging Buah Kedondong (Spondias dulcis Soland. ex Forst. fil.) Sebagai Pelembab Kulit
Authors: Sudewi Sudewi , Febriani Yessi , Raudah Siti , Nofriani Ira , Zebua Nilsya Febrika
Published: January 2022

Kedondong fruit (Spondias dulcis Soland. Ex Forst. Fil.) Is a fruit plant originating from South and Southeast Asia and spread in tropical areas. Kedondong fruit contains vitamins A, B and C, carbohydrates, protein and fat. This study aims to determine the pulp of kedondong (Spondias dulcis Soland. Ex Forst. Fil.) In the form of ethanol extract which can be formulated into a hand body lotion which at certain concentrations can provide a moisturizing effect on the skin and is not irritating. This research was conducted using experimental methods, using the test material of the pulp of the kedondong fruit (Spondias dulcis Soland. Ex Forst. Fil.). The ethanol extract of kedondong pulp (Spondias dulcis Soland. Ex Forst. Fil.) Was obtained by maceration using 96% ethanol filter, then concentrated using a rotary evaporator. The preparation is formulated into a hand body lotion with a concentration of 0.5%, 1.5%, 2.5% and 3.5%, as well as a blank. Examination of the physical quality of the preparation includes, homogeneity test, pH test, emulsion type test, stability test, irritation test and effectiveness test of the preparation in moisturizing the skin and comparing with preparations on the market using the Skin Moisturer Checker (AramÒ) and statistical data processing was carried out using the SPSS 26.00 ANOVA method. The results showed that the pulp of kedondong (Spondias dulcis Soland. Ex Forst. Fil.) In the form of ethanol extract can be formulated into a hand body lotion, a homogeneous preparation with the type of oil-in-water emulsion (M / A), has a momentary pH range. After making 6,6-7,3 and pH after 12 weeks of storage 6,3-7,0, the effectiveness test of moisture preparation at a concentration of 3.5% (Formula E) gave moisture (32%) categorized as "moist" which was statistically showed a significant difference with the comparison results, the hand body lotion that was made did not irritate the skin.
Pemanfaatan Minyak Atsiri Daun Sirih (Piper Betle Linn) Sebagai Anti Nyamuk
Authors: Gunawan Deki , Kurniaty Rina
Published: January 2022

Betel leaf (Piper betle Linn) is a plant that is widely known by the people of Indonesia, contains phenolic compounds and their derivatives which reaches 30% in extracts and essential oils, and at a concentration of 100 ppm it can kill mosquito larvae based on insecticidal activity. This study aims to utilize betel leaf essential oil, which was obtained by steam distillation method in the form of a spray dosage form and to find out at what concentration the betel leaf essential oil can be used as an insect repellent. This research is a laboratory experiment, there are 3 formulas of mosquito repellent spray (F1, F2 and F3) with a concentration of 13%, 15%, and 17%. The tests carried out on the anti-mosquito spray preparation were organoleptic tests and tests the effectiveness of the preparations against ten adult mosquitoes. Anti-mosquito spray preparation with a concentration of 17% betel leaf essential oil which is more effective at repelling and killing mosquitoes. Further research can develop the use of betel leaf essential oil with variations in different concentrations, or in combination with other active ingredients as mosquito repellent
Formulasi Sediaan Lotion Dari Ekstrak Buah Alpukat (Persea Americana) dan Lidah Buaya (Aloe Vera) Untuk Kulit Kering
Authors: Oktaviana Marlia , Rejeki Dwi Putri , Ceriana Ria , Mardiana Rosa , Dita Sasmiati Farach
Published: January 2022

Skin care is needed so that the skin does not become dry, rough, and dull. The way to deal with dry skin is to use a scrub or use a moisturizer such as lotion. One of the active substances contained in lotion preparations is antioxidant compounds. Avocado and aloe vera extracts have antioxidant activity. Avocado and aloe vera have moisturizing benefits. In this study, both types of extracts were formulated into lotion preparations. Avocado and aloe vera extracts were made by maceration method using 70% ethanol as solvent. The extract was formulated with 3 variations, namely the control formula (F0), the avocado extract formula with a concentration of 5% (FI), and aloe vera with a concentration of 10% (F II). The lotion was tested for physical properties including pH, homogeneity, stability, spreadability and irritation tests. The results showed that the lotion containing avocado and aloe vera extracts with storage for two weeks was stable. Does not change shape, smell, color, and does not irritate the skin
Doğu Makedonya Yörük Halk Kültüründe Hıdrellez Kutlama Geleneği
Authors: DESTANOV Ekrem
Published: January 2022

Türk dünyasının kültür değerlerinden biri olan “Hıdrellez” bahar mevsiminin gelişinde kutlanan bayramlarından biridir. Kış mevsiminin bitişini yazın ise başladığını ifade eden Hıdrellez her yılın altı Mayıs tarihinde kutlanmaktadır. Köklü bir geçmişe sahip olan Hıdrellez geleneği Türk kültüründe müstesna bir yer edinmiş olup Türk dünyasında asırlardır özel bir gün olma niteliğini korumaktadır. Bu makalenin konusuyla doğrudan bağlantılı olan Doğu Makedonya Yörük Halk Kültüründe de Hıdırellez geleneğine büyük önem verilmektedir. Ancak bu bölgedeki Hıdırellez geleneği ile ilgili müstakil ve ayrıntılı bilimsel çalışmalar yapılmış değildir. Bu nedenle söz konusu bölgede birtakım törenler eşliğinde kutlanan Hıdrellez geleneğinin bilimsel dünyadaki bilinirliğinin arttırılması amacıyla böyle bir çalışma ele alınmıştır. Söz konusu bölgeden konuya ilişkin halk bilimsel verilerin derlenmesinde folklor derleme çalışmalarında yaygın olarak kullanılan “gözlem”, “görüşme” ve “mülakat” yöntemleri esas alınmıştır. Derleme çalışması sonrasında bu verilerin yedeklemeleri yapılmış olup yazıya aktarılmışlardır. Sonrasında ise söz konusu verilerin nitel araştırma yönte-mindeki teknikler ile çözümlemeleri yapılmıştır. Konuyla ilgili verilerin incelenmesi ve çözümlenmesi sonucunda bölge halkının Hıdrellez bayramını genel anlamda usulüne uygun bir biçimde kutlanmasına büyük önem tespit edilmiştir.
Mihail Çakir’in Gagauzca - Rumence Sözlüğünde Geçen Hayvan Adları ve Hayvancılıkla İlgili Söz Varlığı
Authors: HÜNERLİ Bülent
Published: January 2022

Bir halkın tarih sahnesindeki yerini siyasi, kültürel ve ekonomik gelişmelerle birlikte tarihî şahsiyetleri ile de ele almak gerekir. Özellikle burada halkının kültürünün ve dilinin tarih sahnesinden silinmesine izin vermeyen bir kişi olarak Mihail Çakir’i anmak yerinde olacaktır. O, Gagauzlar arasında sadece din adamı ve öğretmen kimliği ile öne çıkmamış; Rus ve Rumen idaresinde yaşayan Gagauzlara ana dilleri ile ilk yazılı eserleri vermiş ve böylelikle halkı arasında müstesna bir yere sahip olmuştur. Mihail Çakir, Gagauzların ana dilde ibadet etme konusunda oldukça emek harcamıştır. Hristiyan Ortodoks olan Gagauzların ana dilinde ibadet etmelerini bir zaruret görmüştür. Yine Gagauzların tarihine de eğilen Çakir, “Besarabiyalı Gagauzların İstoriyası” adlı eseri kaleme almıştır. Çakir’in diğer dikkate değer bir eseri de Besarabyalı Gagauzlar için hazırladığı Gagauzca (Türkçe)- Rumence Sözlük adlı eserdir. Bu eser küçük hacimde bir eser olmakla beraber bir Gagauz tarafından kaleme alınan ve müstakil bir eser olarak basılan ilk çalışma olması açısından oldukça önemlidir. Eserde Gagauz kültür ve yaşam tarzına dair pek çok kelimenin geçtiği görülür. Özellikle Gagauzların yaşam tarzlarının bir parçası olan tarım ve hayvancılık ile ilgili terimler bunların başında gelir. Makalemizde bu sözlükte geçen hayvan adları ve hayvancılıkla ilgili terimler üzerinde durulacaktır.
Kosova-Gilanlı Gazeteci Burhan Sait’in Türk Dünyası ve Toplulukları Üzerine Yazıları
Authors: GEZGİN Faruk
Published: January 2022

Tito’nun 1980’de ölümü ile federal yapının sarsıntı yaşaması ve 1990’larda ayrı bağımsız devletlerin oluşma süreci başlangıcına kadar, Yugoslavya’da birçok hakkı devlet garantisi altında olan Türkler için –aradaki Yücel teşkilatı davası, idam ve çeşitli mahkûmiyetlerle korkutulan Türklerin Türkiye’ye toplu göç olayı hariç- sosyalizmin devamına taraftar olan Burhan Sait, bunun yürümediğini ve her büyük halkın federal cumhuriyetini bağımsız devlet haline getirmeye başladığını görünce, esasen içinde var olan milliyetçi-Türkçü fikir çerçevesinde faaliyetler bulunur. Daha Tan gazetesinde muhabir ve yazar olarak çalışırken bölge Türklüğü ve Türk Dünyasıyla ilgilenmiş, yazılar yazmıştır. Üsküp’e yerleşip 1994-2002 arasında çıkardığı Vardar dergisi ve devamı olan Vardar gazetesinde Türk Dünyası ile daha çok ilgilenmiştir. Bu sırada bir ara Anadolu Ajansı Üsküp Temsilcisi olmasının verdiği imkânla, Türk Dünyası ile ilgili eline gelen bilgileri değerlendirip bazılarını haber, bazılarını da ayrı yazılar halinde yayınlamıştır. Atatürk’ten sonra Türk Dünyası’na yönelişin en bilinçli temsilcilerinden olan Milliyetçi Hareket Partisi Başkanı Alparslan Türkeş’e de hayran olan Burhan Sait, onun ölümüne genişçe veren bir haber-yazı da yayınlayarak bu hassasiyetini ortaya koymuştur.

Bu çalışma için arşiv taraması yapılmıştır ve Kosovalı yazar ve gazeteci Burhan Sait’in Türk Dünyası ve meselelerine hasredilen yazılarına odaklanılmıştır. Örnek bir aydın üzerinden Balkan Türk entelijansyasının Türk Dünyası’na yaklaşımı ve meseleleri ele alış biçimi örneklemeler üzerinden verilmiştir.
Development of Islamic Teachings through the Translation of the Quran in Various National Languages
Authors: Very Eko Atmojo Moh. Ali Abdul Shomad , Mu'awanah Elfi , Rohmad Ali , Munardji Munardji , Zahrok Umy , Farihin Hibbi , Broto Germino Wahyu , Hidayah Rifa
Published: January 2022

From the research on the translation of the Quran, in various countries in the center of places of worship, it is known that there are already translations so that it is hoped that it will increase interest in reading and understanding the contents of the Quran. The translation of the Quran is an interpretation of the holy book of Islam in a language other than Arabic. The Quran has been translated into most languages by the translator. The translation of the Quran has always been a troubled and difficult issue in Islamic theology. Because Muslims respect the Quran as a miracle and incomparable (i'jaz al-Quran), they argue that the Quranic text cannot be reproduced in other languages or other forms. The translation of the Quran in its history undergoes a lengthy process, for example from the question of authority or the legitimacy of the translator, the law of translation, coupled with the presence of the translation made by the Orientalists making many differences among the scholars in addressing the translation of the Quran.
Taping en rizartrosis
Authors: De cellis Veronica , García Agustina , Pérez Dávila Adriana , Bohr Analía , Scheines Eduardo
Published: February 2022

Introducción: la osteoartritis (OA) de manos es una de las patologías particulares más frecuentes en la consulta diaria. Una de las localizaciones de la OA comúnmente afectada es la articulación trapecio 1° metacarpiana (TPM), denominada rizartrosis, que puede traer, además del dolor, alteraciones funcionales. Respecto al tratamiento, guías nacionales e internacionales recomiendan el uso de ortesis y ejercicios. El taping o vendaje neuromuscular actúa sobre estímulos propioceptivos generando analgesia sin limitación de la movilidad articular. Objetivo: evaluar los efectos de la aplicación de taping, comparado con el tratamiento ortésico convencional, en un programa de rehabilitación de rizartrosis. Material y métodos: fueron incluidos pacientes de ambos sexos, mayores de 45 años con OA primaria que cumplían los criterios clínicos grado II-III de Eaton, y radiológicos grado 2-3 de Kellgren y Lawrence. Fueron divididos aleatoriamente en dos grupos, el GRUPO TAPING (GT) en donde se realizó un vendaje para la TPM y el GRUPO FÉRULA (GF) a quienes se les realizó una ortesis tipo Spica corta en termomoldeable. Todos iniciaron un programa de ejercicios específicos y fueron instruidos en principios de protección articular (PPA). Fueron evaluados al inicio y al mes del tratamiento: dolor (VAS), fuerza muscular (dinamómetro Jamar), habilidad y destreza (picking up test), capacidad funcional (Australian Canadian Osteoarthritis Hand Index: AUSCAN). Para el análisis estadístico se utilizó la prueba T Student, del programa Excel versión 2010. Resultados: fueron ingresados 40 pacientes, 20 en el grupo GF y 20 en el GT. Ambos grupos mejoraron significativamente el dolor al mes de tratamiento con respecto a la evaluación basal: GF= Xi: 5,8 - Xf: 4,2 (p.0013) y GT Xi= 6,1 - Xf= 3,5 (p.0003); y el AUSCAN total GF: Xi: 40 Xf: 35 (p.0028) y GT: Xi: 39 - Xf: 29 (p.007). En cuanto a las subescalas del AUSCAN ambos grupos mejoraron significativamente el dolor y función, solo se encontró una mejoría estadísticamente significativa en la rigidez en el grupo taping GT: Xi 2,65 - Xf: 1,95 (p.004). Conclusiones: en la población estudiada encontramos que ambas modalidades terapéuticas son recomendadas en el tratamiento de rehabilitación conservador de la rizartrosis; observándose mejoría en los parámetros de dolor y función. Sin embargo, el presente estudio indica que se obtienen mejores resultados en la evaluación de la rigidez en el grupo taping comparado con el grupo férula.
Factores que inﬂuyen en las diferencias entre la evaluación global de la actividad de la enfermedad por el paciente y por el médico en pacientes con artritis psoriásica
Authors: Gallino Yanzi J. , Cerda O.L. , Landi M. , Zaffarana C.A. , Schneeberger E.E. , Citera G.
Published: February 2022

Objetivo: Evaluar los factores que inﬂuyen en la evaluación global de la actividad por el paciente (EGEp) y el médico (EGEm) en pacientes con Artritis Psoriásica (APs).
Masa ósea y fracturas en enfermedades reumatológicas autoinmunes
Authors: Brance María Lorena , Larroudé María Silvia
Published: February 2022

El remodelado óseo es un proceso continuo que ocurre a través de la vida; en condiciones fisiológicas normales, los osteoblastos están involucrados en la formación del osteoide el cual es mineralizado y reemplaza el hueso en los sitios donde el osteoclasto produjo resorción ósea para mantener la integridad esquelética.
Spectrum of chronic gastrointestinal diseases with final outcome in children at a tertiary care centre: a single-centre study
Authors: Seerat Iqtadar , Muhammad Atique  , Eitzaz Uddin Khan
Published: January 2022

Chronic gastrointestinal (GI) diseases in children present with a wide range of symptoms. Limited resources in Paediatric Gastroenterology in developing countries like Pakistan cause considerable difficulties in managing children with chronic GI diseases in a timely fashion. This retrospective descriptive study aimed to determine the spectrum and outcomes of chronic GI diseases in children. The study was conducted at the Paediatric Gastroenterology and Hepatology Department, Pakistan Kidney and Liver Institute & Research Centre (PKLI &RC) in Lahore. The duration of the study was from August 2019 to August 2020. A total of 40 children below the age of 15 years with chronic GI diseases were included. The diagnosis was principally established with the assistance of esophagogastroduodenoscopy and ileo-colonoscopy.
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Prolonged jaundice in Hepatitis-E patients: going beyond the optics
Authors: Butt Nazish , Afzal Nayab , Shakeel Danish
Published: January 2022

Hepatitis E virus (HEV) is an RNA virus that is transmitted faeco-orally. Due to unhygienic living conditions and unsatisfactory treatment of drinking water, it is a major cause of acute viral hepatitis in Pakistan. Hepatitis E infection in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may cause prolonged jaundice resulting in serious complications like, severe haemolysis, acute renal failure, encephalopathy and even demise. Although both these diseases occur frequently in our country there is a dearth of literature on the effect of Hepatitis E infection in G6PD deficient patients, leading to higher rate of complications in such patients.
We report a case of 37 years old male who was referred to our hospital with worsening jaundice. Patient had HEV infection with concomitant G6PD deficiency. This case had a different prospect, since it resulted in prolonged jaundice and severe haemolysis. However patient’s condition improved with conservative management.
Public Service Innovation Using Smart Governance
Authors: Ryu Seung , Kim Hyun , Hong Soon
Published: January 2022

Purpose: This study determines the possibility of public service innovation to meet the rapid changes in information technology (IT) and the need for new governance by analyzing three cases in South Korea.

Methodology: The Smart Governance-Decision Support Systems (SG-DSS) in this study is a new form that guarantees the voluntary participation of citizens by applying IT to governance. SG-DSS supports the demand response that fulfills universal values and decisions about priorities by collecting citizens’ needs. It also encourages citizens or stakeholders to participate in establishing implementation plans that are more specific and fit for reality, giving legitimacy to public service policies and developing them into a driving force.

Findings: The three case studies on Korean public policies show how public opinions reflect public service policies. Therefore, the findings of this  study could lay the foundation for customized public services based on intelligent citizen participation by overcoming the current limitations.

Unique contribution to theory, practice and policy: SG-DSS supports the demand response that fulfills universal values and decisions about priorities by collecting citizens’ needs. It also encourages citizens or stakeholders to participate in establishing implementation plans that are more specific and fit for reality, giving legitimacy to public service policies and developing them into a driving force. The core value of smart governance is to apply IT innovations such as big data and AI to public services. Furthermore, advanced technology enables the collection and application of actual public opinions, thereby improving public to be more objective and efficient.
The Okanagan Charter: Evolution of Health Promotion in Canadian Higher Education
Authors: Squires Vicki , London Chad
Published: January 2022

This paper traces the history of health promotion on campuses, including the initial attempts at providing oversight over student behaviour to the increased need for further supports after the influx of World War II veterans onto campuses, to the focus on providing a much broader range of supports that consider well-being from a holistic stance. We describe the current context where campuses are beginning to take a more intentional and organized approach to well-being across Canada; for context, we have included a description of our recent study that explores impactful practices on Health Promotion campuses that have implemented the Okanagan Charter (2015) (Authors, in press). The immediate context with the evolving global pandemic, reliance on online learning, emphasis on diversity and increasing access for all will also be explored. Lastly, we suggest future directions for campuses to take to address the current pressures and how a network of campuses engaged in well-being efforts who are employing whole systems approaches can be a hopeful model for ensuring well-being on Canadian campuses in the future.
Pelatihan dan Pendampingan Pemanfaatan Sistem Informasi Akademik bagi Civitas Akademik SMP Negeri 4 Kecamatan Rambutan
Authors: Hadinata Novri , Agustini Eka Puji , Kurniawan Kurniawan , Sopiah Nyimas , Rosalia Bella
Published: February 2022

SMPN 4 Rambutan District, Banyuasin Regency is one of the junior high schools that was only established in 2019. Currently, most academic administrative activities are still carried out manually such as student data, teacher data, grades data, and attendance data are still in the form of archives, making it difficult to search for data. Based on this, it can be concluded that SMP Negeri 4 Rambutan requires a website-based academic sistem that can solve the problem, besides that training and assistance to the academic community is also needed. This activity is carried out in 3 stages, namely the delivery of materials, training and mentoring. The purpose of this activity is to make it easier for all academics in carrying out the teaching and learning process every day
BURNOUT EM PROFISSIONAIS DE TERAPIA INTENSIVA: UM OLHAR PRÉ E PÓS-PANDEMIA
Authors: Pedro Júlia Pinheiro São , Cunha Danielle Braz Amarilio da , Borges Juliana Barrozo Fernandes , Klein Camila Lisboa , Wanderlei Marília Magalhães , Junior Antonio Garcia Reis
Published: January 2022

Introdução: Sensação de esgotamento, cinismo ou sentimentos negativos relacionados ao trabalho e eficácia profissional reduzida são os caracterizadores da síndrome de Burnout, que possui alta prevalência dentre os profissionais de saúde, estando ainda mais suscetíveis os profissionais que possuem rotina de trabalho mais desgastante, em ambiente de UTI. Discussão: O Burnout na classe médica mostra-se em ascendência, e os estudos apontam que o risco e as apresentações clínicas da síndrome variam conforme a especialidade e as condições às quais o profissional é exposto, como carga de trabalho, aspectos emocionais do paciente e família, índices de mortalidade, dentre outras. Assim sendo, a medicina intensiva recebeu especial destaque na presença de desgaste emocional e físico, fato este que muito se agravou no momento da pandemia da COVID-19. Diversas características mostraram-se influenciadores no esgotamento mental, desequilíbrio psicológico e frustração profissional em relação ao médico intensivista, incluindo profissional do sexo feminino, com prevalência superior ao sexo masculino. Constatou-se que há inúmeras repercussões tanto para a qualidade de vida do profissional, como labilidade emocional e susceptibilidade a outras doenças, quanto prejuízos para a assistência médica, consequência do esgotamento do profissional. Conclusão: Levando em consideração todas as repercussões negativas do Burnout, destaca-se que o estresse prolongado que culmina em esgotamento é um processo que pode ser evitado, a partir da divulgação e conhecimento da síndrome.
OS PERIGOS DAS DIETAS MILAGROSAS SEM ACOMPANHAMENTO DO PROFISSIONAL NUTRICIONISTA
Authors: Anderson Silva Moura Carlos , Dos Santos Yarla Maria , Silva Neto Jerônimo Gregório da , Carneiro Cavalcante Sara Kaline Carvalho , Gomes de Sousa Erica Fernanda , Marcos Honório Filho Silvio , Pereira Alves Maria Eduarda , De Freitas Pereira Thayanne Evellyn , Freitas Pereira Thaynara Cristina de , Mendes de Brito Andrea Nunes
Published: January 2022

A busca pelo corpo perfeito, incentivado pelos padrões impostos pela mídia e sociedade, levam à prática exagerada de exercícios físicos, dietas inapropriadas e sem fundamentação, uso de suplementação sem orientação profissional, uso de anabolizantes e procedimentos estéticos sem necessidade. Certamente, todo o excesso em relação à imagem corporal poderá ter como desfecho o aparecimento de alguns transtornos. Verificar os perigos das dietas milagrosas sem acompanhamento do profissional nutricionista. Realizou-se uma revisão integrativa com base na estratégia PICo. A busca dos artigos foi realizada nas bases de dados PubMed, Scielo, Lilacs, por meio dos descritores nos idiomas português e inglês: “Alimentos, dieta e Nutrição”, “regime alimentar” e “emagrecimento e transtornos alimentares”, unidos com o operador booleano “AND". O acesso às bases de dados foi realizado no período de setembro a outubro de 2021. Foram encontrados 8750 artigos e após a aplicação dos critérios de inclusão restaram 12 artigos. Percebeu-se que cada vez mais, há uma exposição de dietas e cardápios milagrosos realizadas por pessoas, indicando meios para se conseguir o emagrecimento. As dietas milagrosas tem resultados rápidos, mas ineficazes devido à menor ingestão de calorias, não podem ser mantidas por um longo tempo, muitas vezes retornam ao peso anterior ou mesmo até ganham mais peso.
AVANÇOS E BENEFÍCIOS DA NANOTECNOLOGIA NO DESENVOLVIMENTO DAS VACINAS CONTRA SARS-COV-2: UMA REVISÃO INTEGRATIVA
Authors: Henrique Ferracioli Alvarenga Gabriel , Dalcin Dognani Amanda , Inácio de Brito Ana Elisa , Alexandre Bezerra Junior Carlos , Ázara Oliveira Ênio , Débora dos Reis Géssica , Faria Uveda Julia , Gonçalves Cherain Luiz Gabriel , Mendonça Rocha Carollayne
Published: January 2022

Introdução: A nanotecnologia serve como uma ferramenta poderosa com potencial para mitigar infecções, desempenhando um papel fundamental na prevenção, diagnóstico e estratégias terapêuticas para o manejo do COVID-19. Essas estratégias incluem o desenvolvimento de agentes terapêuticos e vacinas para administrar agentes antivirais ao corpo humano. O objetivo do estudo se dá por destacar a associação entre o avanço da nanotecnologia e o desenvolvimento das vacinas contra o Sars-Cov-2. Metodologia: Esta é uma revisão integrativa, em que a busca na literatura se deu através da consulta nas bases de dados eletrônicos PubMed, Google Scholar e Scielo, utilizando as seguintes palavras-chave: “nanotechnology”, “medicine”, “prevention of diseases” e “vaccine”, combinados entre si por operadores booleanos. Resultados e discussão: Nanopartículas podem ser aplicadas como uma medida para reverter a resistência antiviral, que é um desafio de desenvolvimento gradual da terapêutica convencional atualmente disponível. A nanomedicina pode participar no desenho, entrega e administração de vacinas contra COVID-19 porque elas têm uma apresentação de antígeno multivalente e estabilização de antígenos. também podem transportar adjuvantes para aumentar a resposta imune e entrega direcionada de antígenos, como uma vacina de mRNA, que é entregue por uma nanopartícula lipossomal como uma das vacinas candidatas atuais. Considerações finais: Os nanomateriais podem ser considerados candidatos contra infecções virais, especialmente CoVs, devido à sua capacidade de entrar nas células facilmente e interagir com os vírus, ajudando a evitar a replicação do genoma viral. Porém, mais estudos e testes clínicos devem ser realizados para aprimoramento dessa tecnologia.
Valeurs des cycles seuils (Ct) de la RT-PCR du SARS CoV2 et le risque de développer un syndrome de détresse respiratoire aiguë chez les patients atteints de Covid19
Authors:   university Algiers 1 faculty of medicine department of pharmacy, Rabhi Aoub ,   central laboratory of biology. BOLOGHINE IBN ZIRI Hospital. Algiers, Letlout Hamza ,   Hygiene laboratory. TIPAZA - Algeria., Mahrane Sadjia ,   central laboratory of biology. University Hospital Center of Hussein Dey. Algiers., Nouar Selma Laalia , Guechi Zhor , Cherifi Mohamed El Hadi ,   university Algiers 1 faculty of medicine department of medicine.
Published: January 2022

Background. SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19. Methods. 486 patients tested positive for SARS Cov2 by real time RT-PCR were included in this study. All the tests were performed on nasopharyngeal swabs during the first week after symptom onset using Sansure Biotech™ SARS Cov2 real time RT-PCR kits. Patient’s condition was monitored over a period of one month after the onset of symptoms. Results. The mean Ct value in the group of patients who developed acute respiratory distress syndrome (ARDS +) was 18.27 (95% CI: 17.43-19.10) while for the ARDSgroup it was 33.06 (95% CI: 32.77-33.34). Discussion. The Ct values in the group of patients who developed ARDS (ARDS +) were significantly lower than those observed in the ARDS- group. By setting a cut-off value, the determination Ct values (on a qualitative technique) from nasopharyngeal swabs performed during the first week after symptom onset will assist clinicians in risk-stratifying patients. Conclusion. Our data show that the determination of SARS CoV2 RTPCR cycle threshold values from nasopharyngeal swabs performed during the first week after symptom onset may aid in the risk stratification of patients with COVID-19
The Chemical Society of Japan: Striving for Chemical Sciences and Technology for a Sustainable Human Society
Authors: Sawamoto Mitsuo
Published: January 2022

The Chemical Society of Japan (CSJ), with a long history extending over 140 years and membership of ca. 24,000, is one of the world’s largest, most active, and internationally recognized societies in chemistry. The history of CSJ dates back to 1878 (just ten years after the Meiji Restoration, where Japan was reborn), when about twenty motivated and enthusiastic young scholars launched a small organization, the Chemical Society, in Tokyo for the advancement of chemistry. In the following year, the embryonic society was renamed The Tokyo Chemical Society and eventually the current name, The Chemical Society of Japan, in 1921. In 1948, shortly after World War II, the then CSJ merged with the Society of Chemical Industry, founded in 1898, into an integrated organization with the same name: ”The Chemical Society of Japan”. The integration was in part symbolic in defining the renewed CSJ’s perspective: CSJ consists of comparable numbers of individual members from both academia and industry along with supporting company affiliates; its activities cover virtually all segments of pure and applied chemistry along with diverse interdisciplinary areas now extended to physics, biology, medicine, materials, and advanced technology. Since 2011 CSJ is a public interest incorporated association, a nonprofit tax-exempt organization legitimately certified and under the jurisdiction of the Japanese Cabinet.
Peptide Cyclization Methodologies Amenable to in Vitro Display
Authors: Suga Hiroaki , Abbas Ata
Published: January 2022

Display technology platforms offer their own unique set of challenges for chemical transformations, at the heart of which lies peptide macrocyclization. The amenable reactions for peptide macrocyclization on this platform need to meet a number of criteria like high reactivity, selectivity, mild conditions, irreversibility, and in many cases, a unique requirement to be assimilated into the translation machinery. Skillful utilization of these reactions has led to the formation of huge macrocyclic peptide libraries with varied linkages and topographies which have in turn led to the discovery of a number of hits for purposes such as drug discovery and others. Herein, we review those reactions which have mainly been applied in mRNA and phage display and discuss their technical characteristics and significance.
Cooperative Catalysis for Organic Synthesis
Authors: Nakao Yoshiaki
Published: January 2022

Metal catalysis has driven innovation in organic synthesis during the last half-century. An alternative to the traditional strategy of developing catalysts with a single metal center is the combined use of more than one metal complex and the design of their cooperative action to achieve new synthetic transformations. With the rich chemistry of metal catalysis that has been developed over the last five decades, as well as recent advancements in organocatalysis and emerging photoredox catalysis, one can imagine that cooperativity of these known catalytic approaches could enable novel synthetic transformations that have been highly challenging via conventional single-site metal catalysis.
Therapeutic in vivo synthetic chemistry by glycosylated artificial metalloenyzmes for innovative biomedical modality
Authors: Tanaka Katsunori , Chang Tsung-Che
Published: January 2022

This article is to depict the steps taken by our team for the development of glycosylated artificial metalloenzymes (GArMs) that we have used to develop therapeutic in vivo synthetic chemistry. To achieve this goal, we have had to combine technologies developed over the course of a decade that range from protein conjugation methodologies, identification of glycan-dependent targeting, development of functional biocatalysis, and biocompatible reactions. As a result, we have begun to reveal the framework for GArM complexes and their potential towards creating novel biotechnological tools and therapeutic applications.
"Think Globally, Act Locally" An interview with Prof. Ryōji Noyori
Authors: Keinan Ehud
Published: January 2022

Ryōji Noyori was born on September 3, 1938, in Kobe, Japan. He obtained his B.Sc. and M.Sc. in Industrial Chemistry from Kyoto University. In 1967 he obtained a Doctor of Engineering degree from Kyoto University under Prof. Hitosi Nozaki, and in 1968 became an associate professor at Nagoya University. After postdoctoral work with Elias J. Corey at Harvard University, he returned to Nagoya, becoming a full professor in 1972. He served as president of RIKEN (2003-2015), and since 2015 he has been Director-General of CRDS (Center of Research and Development Strategy) of the Japan Science and Technology Agency. Noyori shared the 2001 Nobel Prize in Chemistry with William S. Knowles and K Barry Sharpless. Noyori’s other prominent recognitions include the 1992 Asahi Prize, the 1993 Tetrahedron Prize, the 1995 Japan Academy Prize, the 1997 Arthur C. Cope Award, the 1999 King Faisal International Prize, the 2001 Wolf Prize in Chemistry, the 2001 Roger Adams Award, and the 2009 Lomonosov Gold Medal. Our Zoom interview took place on September 27, 2021, about three weeks after his 83rd birthday. It was early morning in Israel and afternoon in Japan.
"A Scientist and A Musician:" Tête-à-tête with Eiichi Nakamura
Authors: Keinan Ehud
Published: January 2022

Eiichi Nakamura is an old friend. We first met in 1977 at Columbia University when he had just started his postdoctoral research with Gilbert Stork, and I was on my way to Madison, Wisconsin, to begin my postdoctoral research with Barry M. Trost. Over the following 44 years, we have had many opportunities to meet in various countries. I have always enjoyed Eiichi’s original science and Baroque flute music. He and his wife Yoko Nakamura visited my family at our home in Israel, and I had a chance to spend time in their beautiful home in Tokyo. Hence, I found it peculiar to conduct a friendly conversation over Zoom. But electronic communication has become an integral part of our life during the Covid-19 pandemic. It was a relaxed weekend in late October 2021, early morning in Israel and afternoon in Tokyo. It was as close as possible to a face-to-face meeting, spending a couple of hours together while staying in our home offices.
A History of Chemistry in Japan, 1820-1955
Authors: Kikuchi Yoshiyuki , Siderer Yona
Published: January 2022

The history of chemistry in Japan is a chronicle of how the Japanese learned Western chemistry and contributed to its further development. The Meiji Restoration in 1868 is often credited as the starting point of Japan’s introduction to Western science. In fact, Japanese encounters with chemistry started earlier, in the early nineteenth century during the Tokugawa period (1603-1868). Medical doctors took the lead in the reception of chemistry because of their interest in the medicinal properties of chemicals. The development of manufacturing and military industries such as mining and smelting, pottery, brewing, dyeing, photography, and gunpowder manufacturing further stimulated Japanese interest in chemistry. Historical developments of chemistry in Japan thus reflected the process of Japanese modernization and industrialization that eventually led to its prosperity in the twentieth century.
A New Approach for Speech Keyword Spotting in Noisy Environment
Authors: Ye Peiwen , Duan Hancong
Published: February 2022

Keyword Spotting works to detect wake-up keywords in a continuous voice stream, which is widely used in products such as mobile devices and smart home. Recently, DNNs dominate keyword spotting and dramatically improve performance. However, few researchers concerned about noise in speech keyword recognition. Thus, we propose an architecture for the detection under noisy scenario. Our framework combines attention mechanism and residual structure based on the CNN backbone. In addition, we use separable convolution to reduce the number of model’s parameters, which makes it applicable in the embedded devices. Noises from various scenes are utilized for data augmentation to boost performance. The proposed method achieves an accuracy of 94.93% on the noisy test set based on the Google Speech Commands dataset. We also compare performance between the proposed method and RNN-based algorithm, and prove our model achieve higher accuracy with fewer parameters.
O programa de linguística geral no manuscrito Hacia una lingüística integral (Por uma linguística integral) de Eugenio Coseriu
Authors: Pinheiro Clemilton Lopes , Silva Sílvio Luis Da
Published: February 2022

Este trabalho dedica-se à recensão do manuscrito Hacia una lingüística integral (Por uma linguística integral) de Eugenio Coseriu, que constitui a transcrição de um curso que o linguista ministrou na Universidade Autônoma do México, em 1975.  O manuscrito mobiliza uma série de temas, definições e problemas de forma a compor uma unidade e a apresentar as distinções básicas que fundamentam a tarefa de uma linguística integral: a linguística que deve dar conta dos diferentes aspectos envolvidos no complexo funcionamento da linguagem com base em um marco homogêneo e unitário.
The Impact of SARS CoV-2 on Children and Adolescents
Authors: Clark Alexandra
Published: January 2022

The impact of SARS CoV-2 on children and adolescents is frequently dismissed as less of a burden than the disease in adults. And while the percentage of severe illness in this age range is less than the percentage of severe disease in patients over 65 years old, the impact goes well beyond the physical burden of disease. Educational losses, caregiver loss, and the emotional burden of the pandemic will be elements whose full impact will not be known for likely decades to come.
Industria de la construcción: ¿fragmentada o integrada?
Authors: Giménez Palavicini Zulay
Published: January 2022

Últimamente se encuentran términos dentro en la industria AEC (Arquitectura, Ingeniería y construcción por sus siglas en inglés), como planificación colaborativa, diseño concurrente, equipos integrados, planificación e integración temprana. Estos responden a metodologías no tradicionales que traen consigo altos beneficios de ahorros de tiempos, costos, progresos en la productividad y calidad, mejoras notables en la constructabilidad, así como en la fluidez de información y comunicación del proyecto