bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Serum Magnesium Levels and HbA1C in Type 2 Diabetes Mellitus
Authors: Kondeti Madhavi , Lalitha Thejaswini , Durgam Sathyam , M Anuswaru
Published: September 2021

Background and Objective: Type 2 Diabetes Mellitus is a chronic disease resulting from acomplex inheritance, environmental interaction along with risk factors such as obesity andsedentary life style. Magnesium has been stated to have potential role in improving insulinsensitivity and preventing diabetes related complications. Hypomagnesaemia is proposed as oneof the factor in the pathogenesis of diabetic complications. The aim of our study is to estimatethe correlation between serum Magnesium levels and the level of Glycemic control (HbA1c) inpatients with Type 2 Diabetes Mellitus.Methods: This is an observational study conducted in SVRRGGH and SVMC, Tirupati, AndhraPradesh which included 94 patients with type 2 Diabetes mellitus of more than 5 years duration.These patients were divided into 2 groups based on level of Diabetic control. Group A included30 patients with HbA1c below 7.0mg/dL (good glycemic control) and Group B included 64patients with HbA1c above 7.0mg/dL (poor glycemic control). In both the groups SerumMagnesium levels were estimated.Results: Mean Serum Magnesium levels in Group A was 2.280±0.3955mg/dL while in Group Bit was 2.087±0.5834 mg/dL with a p-value 0.0379 (<0.05) which is statistically significant. Inour study though the mean values of serum Magnesium are within normal reference range, meanvalues of serum Magnesium levels in patients with poor glycemic control(HbA1c>7.0) arestatistically low as compared to patients with good glycemic control (HbA1c <7.0).Discussion: It has been reported that Serum Magnesium levels are lower in uncontrolleddiabetics when compared to controlled diabetics and also serum magnesium levels vary withtreatment for diabetes. In our study, although the mean values of serum magnesium in bothgroups are within Normal reference range (1.7-2.2mg/dL), they are statistically low in groupwith poor glycemic control (HbA1c >7.0mg/dL) when to group with good glycemic control(HbA1c< 7.0mg/dL).Thus this gives an insight into the association of hypomagnesaemia andlevel of diabetic control.Conclusion: This effective comparative study of deals with varying Magnesium levels inspecific diabetic therapies and analysed the effect of urinary magnesium detected inHypermagnesuria with Magnesium supplementation.
Polymorphisms of CYP1A1 Genes and Its Correlation with Clinical Variant of Pterygium
Authors: Hendriati  , H Vitresia
Published: September 2021

Background and Objective: CYP1A1 gene, which has role in carcinogenic metabolisms, is also detected in pterygium tissue. The aim of the study is to determine the polymorphisms of CYP1A1 m2 (rs1048943) and m4 (rs1799814) gene and its correlation with clinical variant of the pterygium.

Methods: DNA isolation was performed from blood sample of 80 pterygium patients consisting of 40 inflammatory and 40 non-inflammatory pterygium. Genotyping of rs1048943 SNP AG (m2) in the CYP1A1 gene was performed using Alel Specific Polymerase Chain reaction (AS-PCR) and rs1048943) SNP Genotyping was performed using PCR. Polymorphism results are characterized as wild type (AA), mutant homozygote (GG), and mutant heterozygote (AG).

Results: CYP1A1 m2 and m4 gene polymorphism consist of wild type (AA), mutant homozygote (GG), and mutant heterozygote (AG). Both CYP1A1 m2 and m4 genes polymorphism of both groups of inflammatory and non-inflammatory pterygium was mostly consist of wild type polymorphism, followed by the mutant heterozygote polymorphism. The wild type polymorphism was found to be higher in inflammatory pterygium, meanwhile the mutant heterozygote was found to be higher in non-inflammatory pterygium.

Conclusion: There were differences in CYP1A1 m2 and m4 gene polymorphism in both pterygium group, but none has been shown to be statistically associated with the clinical variant of the pterygium.
Bacterial Causes of Urinary Tract Infection among Diabetic and Non-Diabetic Patients in Al-Kut City, Iraq
Authors: Jwad Taher Taqi Mohammed , Rashed Sarray Firas Turki , Shwekh Ammar Shimal , Mareedh Tariq Kuraidi , Ghazi Hasanain Faisal
Published: September 2021

Introduction: Urinary tract infection is a very prevalent disease among humans and it is highly presented among patients with diabetes mellitus. The main aim of the current study was to find out the commonest bacterial organisms causing urinary tract infection among a sample of diabetic and non-diabetic patients in Al-Kut city, Iraq.

Methods: A cross-sectional study was conducted among 100 conveniently sampled patients suffering from urinary tract infections and attending Al-Karama Teaching hospital laboratory for urine culture between October and December 2019 were included in the study. The patients were consented to answer a special questionnaire containing data like patients' age, gender, and disease status (diabetic or non-diabetic).

Results: From the 100 participated patients there were 29 (29%) with diabetes and the remaining 71(71%) from the sample were non-diabetics. The females represent the majority of the sample (67%) while males represented only (33%). The most common identified bacteria from this sample were Staphylococcus aureus (48%), Escherichia coli (24%), Klebsiella pneumoniae (17%), Enterococcus species (5%), and Pseudomonas aeruginosa (2%). The study result shows a significant association of being diabetic or not >0.001, 0.038with age and gender of the patients (p-value) respectively. While this association was non-significant when considering the type of bacteria between the two . While this association was non-significant when considering the groups (P-value=0.056).type of bacteria between the two groups (P-value=0.056).

Conclusion: The urinary tract infection is frequently presented among young non-diabetic females and near half of the urine cultures showed the Staphylococcus aureus bacteria as the commonest cause of infection among them.
Inmunidad colectiva contra la COVID-19
Authors:   Sociedad de Obstetricia y Ginecología de Venezuela, González-Blanco Mireya
Published: September 2021

No abstract
Caracterización clínica y epidemiológica de pacientes con enfermedad de von Willebrand que consultan por sangrado uterino anormal atendidas en una institución de alto nivel de complejidad.
Authors: Martínez-Sánchez Lina María , Guevara Zambrano Ana María , Hormaza Ángel María Patricia , Muñoz Ríos Johan Harley , Roldán Tabares Mabel Daiana , Jaramillo-Jaramillo Laura Isabel , Herrera Almanza Laura , Villegas-Alzate Juan Diego
Published: September 2021

Objective: Characterize clinically and epidemiologically patients with von Willebrand disease and abnormal uterine bleeding. Methods: A cross-sectional descriptive observational study was carried out. The study population was women with a diagnosis of von Willebrand’s disease who consulted in a highly complex institution in the city of Medellín. The analysis was carried out through the SPSS V 24 program. Results: 70 patients were included, 50 of these were discarded because they did not present abnormal uterine bleeding or had other diagnoses that could intervene in the characterization as antiphospholipid syndrome. The median age of the included patients was 19.5 years (Min: 11, Max: 52). 9 patients (60%) used contraceptive methods, the reported methods were combined oral contraceptives (26.7%), intrauterine devices (20%) and surgical methods (13.3%). Regarding the clinical characterization, it was found that the most frequent manifestations were the presence of bruises 40% (8) and epistaxis 40% (8). Most of the patients, 65% (13) had not received treatment for abnormal uterine bleeding. Laboratory tests showed the following: hemoglobin 13 g/dL (6.6 - 15.7), hematocrit 37.5% (20.3 - 46.1), platelets 279,000 cells/mm3 (106,000 - 393,000), von Willebrand factor plasma antigen 68.5 IU (19.7 - 205), von Willebrand factor plasma activity 44 IU (23 - 126). Conclusion: Abnormal uterine hemorrhage is a frequent manifestation in women with von Willebrand disease and can present at different stages of life, despite its diagnosis, women do not receive management of this clinical manifestation until their consultation with gynecology. Key words: von Willebrand Diseases, von Willebrand Factor, Abnormal uterine bleeding, Metrorrhagia.
Development of a multi-frequency interferometer telescope for radio astronomy (MITRA)
Authors:   , Ingala Dominique Guelord Kumamputu
Published: September 2021

This dissertation describes the development and construction of the Multi-frequency Interferometer Telescope for Radio Astronomy (MITRA) at the Durban University of Technology. The MITRA station consists of 2 antenna arrays separated by a baseline distance of 8 m. Each array consists of 8 Log-Periodic Dipole Antennas (LPDAs) operating from 200 MHz to 800 MHz. The design and construction of the LPDA antenna and receiver system is described. The receiver topology provides an equivalent noise temperature of 113.1 K and 55.1 dB of gain. The Intermediate Frequency (IF) stage was designed to produce a fixed IF frequency of 800 MHz. The digital Back-End and correlator were implemented using a low cost Software Defined Radio (SDR) platform and Gnu-Radio software. Gnu-Octave was used for data analysis to generate the relevant received signal parameters including total power, real, and imaginary, magnitude and phase components. Measured results show that interference fringes were successfully detected within the bandwidth of the receiver using a Radio Frequency (RF) generator as a simulated source. This research was presented at the IEEE Africon 2013 / URSI Session Mauritius, and published in the proceedings.
Immunological Responses and Survival Outcome in HIV and SARS-CoV-2 Coinfected Patients
Authors: Jilani Uzma A. , Othman Zulhabri , Jilani Syed A.
Published: September 2021

The coronavirus disease 2019 (COVID‐19) has created a worldwide crisis, raising fears and concerns regarding clinical outcomes in patients with comorbidities. Some of the highly prevalent communicable and non-communicable diseases worldwide are cardiovascular diseases, diabetes, HIV/AIDS, and hepatitis B and C, which reduce the host immune responses to concurrent acute infections. Despite over 170 million confirmed cases of COVID‐19 worldwide as of 24 June 2021, insufficient data is reporting the prognosis of HIV and SARS-CoV-2 co‐infection. This narrative review aims to present current knowledge on the impact of SARS-CoV-2 on people living with HIV/AIDS, in terms of immunological responses and clinical outcome. Although some studies have been performed and are in progress to determine the impact of SARS-CoV-2 infection on patients living with HIV/AIDS, controversies still exist whether COVID-19 severity and mortality are higher among this special subgroup or similar to the general population.
Risk Factors Analysis of Acute Kidney Injury Incidence Following Coronary Artery Bypass Graft with Cardiopulmonary Bypass in Indonesia
Authors: Adisurya Ghuraba , Abbas Kun Arifi , Setiawan Philia , Perdhana Fajar
Published: September 2021

Introduction: The incidence of postoperative CABG AKI in Indonesia, one of which is in the city of Surabaya, is known to reach 69.8%. For this reason, this study was prepared with the aim of analyzing the risk factors of Acute Kidney Injury Incidence following coronary artery bypass graft with cardiopulmonary bypass.
Method: The study conducted a prospective analytic study on CABG patients with the CPB technique without a history of previous kidney disease at a hospital in Indonesia in the period 2020.
Results: Through the results of the study, it was found that 14 people were diagnosed as AKI after surgery, of which 11 were men. On the other hand, it is also known that AKI patients also experience a longer duration of CPB and also lower plasma osmolarity
Conclusion: Of all the factors it is known that eGFR is an independent risk factor for AKI.
Performance Analysis of An Arduino Based Calibration and Temperature Control System for A Refractance Window Dryer
Authors: Mutumba Raymonds , Kigozi Julia , Tumutegyereize Peter , Ssenyimba Shaffic , Muyonga John
Published: September 2021

Automated control of temperature in fruit dryers is important for product quality and retention of nutrient content. In this study, the continuous refractance window dryer (RWD) was calibrated for drying temperature to enable the dryer to be set to dry a wide range of products. The drying operation in a RWD is carried out over a bed of hot water. The calibration system comprised of a computer program, calibrated knob, arrangement of sensors and output components. A computer program was successfully written in Arduino environment and a circuit board connected. A DS18B20 sensor was used to read the hot water temperature and a 5V potentiometer employed to vary the voltage as it corresponds to the desired water temperature. The system calibration focused on drying temperatures for mango, tomato and pineapple, but it can be applied to any other food products since the optimum drying temperature for most food products falls within the considered range. A calibration equation relating potentiometer voltage and temperature was formulated with the potentiometer maximum angular sweep found to be 295°. This angular sweep corresponded with 94.9996°C as the maximum calibration temperature. The system was found to be 97.6% accurate at attaining the desired temperature. A calibrated label was developed and marked accordingly. The developed system was simple to operate and robust throughout the testing hence it can be recommended for similar machines.
Visualization and the Cost of Maintaining Horses in a Stable Business with the Concept of a Horse Riding School in Bantul Regency
Authors: Kusumawardani Dina Agustin , Nugroho Bambang Ali , Kuswati Kuswati
Published: September 2021

This study aims to identify the business model canvas (BMC) and analyze the implications of the cost structure of raising horses in Rumah Berkuda Yogyakarta which has a concept horse riding school. The research method uses descriptive qualitative and quantitative. The results showed that the targeted customer segments were parents of children, adults, photo shoots with horses and horses’ owner without stable. Value Propositions in the form of strategic locations, riding training for children and adults, stable rental services, various training package prices, training time to follow visitors, and horses for training more than 2 tails. Channels are in the form of word of mouth and social media promotions. Customer relationships in the form of making t-shirts, renting cages and providing souvenirs and bonus lessons. Revenue stream from equestrian training services and cage rental. Key resources in the form of horses, human resources, facilities, and finance. Key activities include horse maintenance, visitor services as well as promotion and administration. Kay partnership in the form of shops for feed, medicine and equestrian equipment, providers of cage mats, providers of grass, t-shirt convection and social media around. The cost structure includes the basic costs of maintenance and operational costs of horse maintenance. The total monthly percentage of fixed cost is 19.44% and the percentage of total variable cost is 80.55% of the total percentage of horse maintenance.
Temporal Lobe Epilepsy Misdiagnosed as Schizophrenia: A Case Report
Authors: Anugwom Gibson O. , Urhi Alexsandra , Otuada David O. , Oladunjoye Funso , Dilibe Arthur , Ogwu Dolly , Odugbesan Temidayo , Osa Egbebalakhamen , Ejiyooye Toluwalope , Olatunde Hafiz
Published: September 2021

Temporal lobe epilepsy is a neurological disorder of an unprovoked type of focal (partial) epilepsy that begins in the temporal lobe of the brain. Patients with this condition are often misdiagnosed due to similarities in presentation to other conditions. In this case report, we presented a 34-year-old male, who had symptoms of hallucination, anxiety, and depression which can be seen in patients with temporal lobe epilepsy. Due overlap in symptoms, he was misdiagnosed to have schizophrenia. Following subsequent review of his medical history and findings seen in his laboratory work and imaging studies, it was determined that his symptoms were caused by seizures originating from an atrophic lesion in his hippocampus found on magnetic resonance imaging of his temporal lobe.
Kinetic modeling of the biodiesel production process using neem seed oil: An alternative to petroleum-diesel
Authors: Oyegoke Toyese , Ibraheem Kazeem Ajadi
Published: September 2021

Promoting the green technology campaign that would actualize a biorefinery establishment and would promote cleaner fuel production and air in our environment. This study carried out kinetics studies of biodiesel production over a mixed oxide, Ca-Mg-O catalyst, providing relevant kinetics parameters. This study indicated that biodiesel production is a zero-order reaction, a process independent of the concentration. The results obtained from this study confirm the activation energy, Ea, of the reaction to be 406.53 J/mol, while the pre-exponential factor A was found to be 0.01618 1/min (or 0.9 1/h). Other are kinetics models that were developed for the prediction of the reaction kinetics for the production process is also reported in this study. The findings reported in this study would go a long way to facilitate the modeling, simulation, and design of the biodiesel production process.
Synthesis, crystal structure, and theoretical studies of a macrocyclic silver(I) complex of imino-pyridyl Schiff base ligand
Authors: Mondal Jahangir , Sahu Meman , Sharma Bhaskar , Ganguly Rakesh , Chowdhury Shubhamoy , Patra Goutam Kumar
Published: September 2021

The synthesis and characterization of an imino-pyridyl ligand N,N'-(butane-1,4-diyl)bis(1-(pyridin-2-yl)methanimine) (L) and its Ag(I)ClO4 complex (I) by various spectroscopic techniques and elemental analyses is presented in this study. X-ray single crystal structure of complex I revealed that in complex I, each Ag(I) ion is tetra coordinated with two pyridine N-atoms and two imine N-atoms of the ligand L, forming a macrocyclic dimeric Ag(I) grid. In the macrocyclic dimer complex I, Ag-Ag separation along the chain is 5.318 Å. The Ag-Npy average distance is 2.396 Å and that of the Ag-Nim is 2.257 Å. The macrocyclic dimer complex I is supramolecularly arranged by π-stacking interactions. Computational, Hirshfeld surface analysis and photophysical studies on ligand L and complex I have also been performed. Crystal data for C32H36Ag2Cl2N8O8 (M =947.33 g/mol): Triclinic, space group P-1 (no. 2), a = 9.1714(12) Å, b = 10.4373(14) Å, c = 10.8297(14) Å, α = 112.317(3)°, β = 91.391(3)°, γ = 92.353(3)°, V = 957.3(2) Å3, Z = 1, T = 293.15 K, μ(MoKα) = 1.220 mm-1, Dcalc = 1.643 g/cm3, 10248 reflections measured (4.07° ≤ 2Θ ≤ 53.098°), 3966 unique (Rint = 0.0280, Rsigma = 0.0331) which were used in all calculations. The final R1 was 0.0722 (I > 2σ(I)) and wR2 was 0.2229 (all data).
N'-(Pyridin-3-ylmethylene)benzenesulfonohydrazide: Crystal structure, DFT, Hirshfeld surface and in silico anticancer studies
Authors: Ozochukwu Ifeyinwa Stella , Okpareke Obinna Chibueze , Izuogu David Chukwuma , Ibezim Akachukwu , Ujam Oguejiofo Theophilus , Asegbeloyin Jonnie Niyi
Published: September 2021

A new Schiff base, N'-(pyridin-3-ylmethylene)benzenesulfonohydrazide, was synthesized and characterized by elemental analysis, IR, Mass, 1H NMR and 13C NMR spectroscopy, and single-crystal X-ray determination. The asymmetric molecule crystallized in the monoclinic crystal system and P2(1)/c space group. Crystal data for C12H11N3O2S: a = 9.7547(4) Å, b = 9.8108(4) Å, c = 13.1130(5) Å, β = 109.038(2)°, V = 1186.29(8) Å3, Z = 4, μ(MoKα) = 0.270 mm-1, Dcalc = 1.463 g/cm3, 13338 reflections measured (5.296° ≤ 2Θ ≤ 55.484°), 2790 unique (Rint = 0.0494, Rsigma = 0.0400) which were used in all calculations. The final R1 was 0.0345 (I > 2σ(I)) and wR2 was 0.0914 (all data). In the crystal structure of the compound C12H11N3O2S, molecules are linked in a continuous chain by intermolecular of N∙∙∙HN=N hydrogen bonds. The pyridine moiety is planar, while the benzenesulfonohydrazide group adopts a gauche conformation about C-S-N angle (105.54°). The Hirshfeld surface analysis and fingerprint plots were used to establish the presence, nature, and percentage contribution of the different intermolecular interactions, including N-H∙∙∙N, C-H∙∙∙O, C-H∙∙∙C, and π∙∙∙π interactions, with the C-H contacts having the most significant contribution. The pairwise interaction energies were calculated at the B3LYP/6-31G(d,p) level of theory, and interaction energy profiles showed that the electrostatic forces had the most significant contribution to the total interaction energies of the different molecular pairs in the crystal. In-silico technique was used to examine the compound as a possible anticancer agent. The molecule demonstrated zero violation of the criteria of Lipinski’s rule of five with a polar surface area of 116.03 Å2. The molecule displayed favorable binding interactions with ten selected validated anticancer protein targets ranging from -9.58 to -11.95 kcal/mol and -2.73 to -5.73 kcal/mol on scoring and rescoring, respectively, with London dG and Affinity dG scoring functions. Two proteins; farnesyl transferase and signaling protein, preferred interactions with the Schiff-base over their co-crystallized inhibitors according to London dG scoring. Analysis of binding poses indicated that the Schiff-base made contact with amino acid residues of the two proteins through the N-H, sulphonyl oxygen, and phenyl groups, and this could be exploited in chemical and structural modification towards activity optimization.
Theoretical study of the adsorption of BMSF-BENZ drug for osteoporosis disease treatment on Al-doped carbon nanotubes (Al-CNT) as a drug delivery vehicle
Authors: Al-Sawaff Zaid Husham , Dalgic Serap Senturk , Kandemirli Fatma
Published: September 2021

The adsorption energy of the BMSF-BENZ adsorbed complexes was investigated to understand the non-local dispersion interactions, with many other chemical parameters related to this subject like HOMO and LUMO, energy gap, and the time needed for the BMSF-BENZ to be desorbed from the nanotube (recovery time). Our study reveals that Al-CNT is a promising adsorbent for this drug as Eads of BMSF-BENZ/Al-CNT complexes are -22.09, -38.68, -12.89, -31.01, -27.31, -21.90, and -21.42 kcal/mol in the gas phase on the active atoms of the BMSF BENZ (Br, N8, N9, N58, O35, O41, and S), respectively. In addition, the spontaneous and favorable interaction between the BMSF BENZ and all nanoparticles was confirmed by investigating Gibbs free energy and quantum theory of atoms in molecule analysis (QTAIM) so that it can be used as an electrochemical sensor or biosensor. Furthermore, to more visualize the nature of intermolecular bonding and the strength of interaction between the BMSF-BENZ drug molecule and the nanotube, QTAIM has been widely studied in the case of drug delivery purposes.  Al-CNT (4,0) can be extended as a drug delivery system and the work function type sensor.
Synthesis, reactions and applications of naphthofurans: A review
Authors: Abdelwahab Ashraf Hassan Fekry , Fekry Salma Ashraf Hassan
Published: September 2021

Considering the highly important biological and medicinal properties of naphthofurans, the synthesis of these heterocycles has attracted the interest of medicinal and organic chemists. This review aims to describe the different strategies developed so far for the synthesis of naphthofurans and their applications and the literature reports for the period of 2000 to early 2020. After a brief introduction of the types of naphthofurans and their biological activities, the different synthetic approaches such as chemical and photochemical, methods are described and organized on the basis of the catalysts and the other reagents employed in the syntheses. Some of the reactions have been applied successfully to the synthesis of biologically important compounds.
Editorial Board
Authors: Arslan Hakan
Published: September 2021

Editorial Board
TAX RISES IMPACT ON THE SPENDING PATTERN OF THE POPULATION IN GREATER ACCRA REGION OF GHANA
Authors: Mantey Isaac , Frempong Abigail , Aryee Christopher Lartei , Ampofo Justice Agyei
Published: September 2021

The study was aimed at examining the role of high tax rises on the spending patterns of the people in Accra township of Ghana. The research gathered data from both secondary and primary sources and used the quantitative research method approach. The key instruments used for the data collection was questionnaire. In all seventy (70) respondents were selected for the study comprising thirty five (35) people from Accra township and thirty five (35) University of Ghana students. The study found out that taxation is very good for nation building since the allocation of funds depends upon the collection of taxes and the government used that revenue for specific purposes. This has a direct economic impact on the socio economic development of Ghana. The study found out that there is a fairly strong relationship between people spending and high tax rises. That is to say the study found out that when tax is high it affects people spending negatively especially the poor because it reduces their income levels, put a tax burden on them, it increases their expenditure and it also increases poverty. The study found out that to be able to ensure effectiveness and efficiency in our tax system it is essential to strike the right balance between designing an attractive tax, there must be transparency and effectiveness in the tax system, tax reform needs to be promoted to widen the tax base and bring a larger part of the population into the formal economy and also tax must reduce excessive reliance on aid and offers a path away from unsustainable revenue streams  It is recommended that the government of Ghana should structure the tax based system in a way that there is no inequality in the payment by the poor and the rich and also the people of Ghana should understand the importance of taxation for the development of Ghana and hence there should not be invasion of tax since tax brought to light the importance of tax.
Keywords: Tax, Spending Pattern, Population, Greater Accra Region, Ghana.
THE CONCEPT OF CONSUMER BEHAVIOR: DEFINITIONS IN A CONTEMPORARY MARKETING PERSPECTIVE
Authors: Nassè Dr. Théophile Bindeouè
Published: September 2021

There have been some multiple understandings and considerations of the concept of consumer behavior, however little is known about the concept in this contemporary area. This research purpose is to explore the concept of consumer behavior under different aspects of its interpretation. The approach is based on a sound documentary analysis, with some direct and indirect observations.  It consists of a sound search for relevant literature, followed by the evaluation of sources, an identification of themes, and gaps.
The results show that there are some similarities but also some differences in the definition of the concept following the research context. As such, there is not a quite common definition of this concept. However, a common conception of consumer behavior refers to the particular perceptions of habits, lifestyles, attitude and practices.
 Keywords: Consumer behavior, Consumption, Africa, Marketing.
The role of agroholdings in the creation of cooperatives by rural communities
Authors: Skydan Oleh , Budnik Olha , Sus Lesya
Published: September 2021

Purpose. The purpose of this study was a theoretical and methodological generalization of the agroholdings’ social initiatives within their charitable activities with the interaction of cooperatives based on the institutional model.

Methodology / approach. This study was based on applying the general economic and special methods. The abstract-logical method was used for scientific discussion and scientific views about the role of agroholdings and their impact on the rural population. The method of critical analysis was applied to outline the social aspects of agroholdings’ activities. The system approach allowed contouring the main problems that arise in the process of agroholding growing. The study of the state of agricultural cooperatives’ financing by agroholdings was also conducted. On the basis of the monographic method the motives and directions of the management of separate agroholdings within their social responsibility limits were defined. With the generalization method, the basic forms and resources of agroholdings’ social responsibility were determined. Thanks to the correlation-regression analysis, it was established the relationship between the social responsibility indicator of agroholdings and their efficiency by EBITDA, as well as their social responsibility and market capitalization degree.

Results. The study examined the main scientific approaches to the role of agroholdings, which allowed outlining their ambiguity and contradictions. The systematization of the presented materials allowed developing arguments in favor of the agroholdings’ functioning and identifying counterarguments of their activities as well as emphasizing the need of the basic methodological provisions for further harmonious development of agroholding structures and cooperatives. The results of the presented empirical analysis showed a low level of agroholdings’ social responsibility, which affects the development of the rural areas and significantly increases social tensions. On the basis of the conducted research and data processing the mechanism of agroholdings’ and cooperatives’ interaction on the basis of social responsibility is offered. It was proved that the basis of the presented interaction must be financial and economic, social, marketing and environmental motives.

Originality / scientific novelty. It was improved the theoretical and methodological approach to the formation of institutional model of the agroholdings’ and cooperatives’ interaction on the principles of social responsibility, which provides financial and economic, social, marketing, environmental problems solutions by agroholdings and promotes the rural community’s development in the near future.

Practical value / implications. The results of the study are of great practical importance and can be useful for various ownership forms of agricultural producers as well as for agricultural holding organizations which are interested in harmonizing the rural economy development.
Ефективне використання «чистих» земель України в умовах сталого розвитку
Authors: Budziak Olha , Budziak Vasyl , Hrytsak Оlena
Published: September 2021

Мета. Мета статті – дослідити ефективне використання «чистих» земель у процесі урбанізованого (міського, сільського, селищного) розвитку як одного з аспектів боротьби з деградацією земель України в умовах сталого розвитку шляхом збереження земель для майбутніх поколінь.

Методологія / методика / підхід. Методологічний підхід передбачає вивчення світової практики управління земельними ресурсами та землекористуванням. Оцінювання ефективного використання земель базувалося на дослідженні темпів споживання «чистої» землі міськими агломераціями й іншими населеними пунктами до темпів приросту/скорочення наявного населення України в період 2000–2018 рр.

Результати. Установлено, що землі міст у структурі земельного фонду країни становлять 12 %. Досліджено, що за період з 2000 до 2018 рр. споживання «чистих» земель в Україні відбувалося в містах зі швидкістю 48,8 км2 або 0,01 % за рік та 266 км2 або 0,04 % за рік у селах і селищах. Разом із цим зросла й площа землі відведеної під забудову з розрахунку на одного мешканця міста на 0,008 га/чол. та одного сільського жителя на 0,11 га/чол. Виявлено, що при зменшенні загальної чисельності населення, в тому числі міських жителів, за досліджуваний період відбувся внутрішньо-регіональний міграційний його приріст у 2,1 %, зумовлений як пошуком роботи, так і переселенням населення з тимчасово окупованих територій Донецької та Луганської областей, АР Криму, який призвів до необґрунтованого збільшення площ забудованих земель населених пунктів окремих регіонів. Однак темпи скорочення чисельності населення в динаміці все ж виявилися значно вищими за темпи зниження обсягів споживання «чистої» землі, що характеризує використання земель як мало ефективне. Швидкість споживання «чистих» земель в Україні становила 315 км2 за рік і є однією з найнижчих порівняно з країнами ЄС, однак основним орієнтиром, як і в розвинених країнах світу, має стати досягнення до 2050 р. нульового рівня споживання «чистих» земель.

Оригінальність / наукова новизна. Уперше досліджено ефективне використання «чистих» земель, основне призначення яких – забезпечити збереження та функціонування природних екосистем для невиснажливого, довгострокового та ефективного їх використання, а також доведено вплив внутрішньо-регіональної міграційної активності населення, зокрема, внутрішньо переміщених осіб з окупованих територій, на темпи споживання земель України.

Практична цінність / значущість. Результати дослідження можуть служити як орієнтиром для порівняння швидкості споживання «чистих» земель України в майбутньому, щоб зменшувати темпи втрат родючих земель та напівприродних чи природних територій, так і для оцінки прогресу сталого управління землею в цілому.
A RELAÇÃO DO ENSINO REMOTO NA EVASÃO ESCOLAR EM UMA ESCOLA DO CAMPO NO MUNICÍPIO DE CAUCAIA-CE
Authors: Morais Luísa Maria Evangelista , Julião Kátia Karoline Alves , Julião Raquel Alves , Rolim Ronnielle Cabral , Silva Maria Helenice Rocha
Published: September 2021

O agravamento da pandemia de COVID-19 impõe muitos desafios para o cenário educacional, sobretudo na Educação, o sistema adotado para que a educação continuasse mesmo em tempos tão difíceis foi o ensino remoto, de modo que a evasão escolar vem sendo notada com mais frequência, um quadro que preocupa muitos educadores. O que fazer com alunos em comunidades carentes, com pouco acesso à internet ou nenhum acesso, assim como também aos equipamentos tecnológicos necessários a essa nova modalidade? Para isso, foram entrevistados oito professores de diferentes segmentos da escola pública do município de Caucaia do estado do Ceará quanto à percepção deles em relação à evasão escolar no ensino remoto, na coleta de dados foi realizada uma entrevista com professores de uma escola do campo. A análise e interpretação dos dados foi realizada em percentuais e  médias tabulados por meio do software Excel. Além disso, foram utilizados e atribuídos a eles significados, confrontados à luz da literatura. Assim, os professores responderam que 40% dos alunos que evadiram são do sexo masculino, 25% do sexo feminino e 35% não souberam responder. Além disso, os alunos apresentaram uma maior adesão à entrega das atividades quando as mesmas foram entregues em forma de blocos na escola para entrega posterior. Uma vez que, poucos alunos têm acesso a internet, seja ela em dados móveis ou Wi-Fi e que a marginalidade vem aumentando entre os alunos. Conclui-se que a evasão escolar tem se tornado cada vez mais presente nas escolas, tendo sido acentuada pela pandemia do COVID-19.
O EFEITO IMUNOMODULADOR DA MICROBIOTA INTESTINAL, AS CONSEQUÊNCIAS DE SEU DESEQUILÍBRIO E A PROFILAXIA PROBIÓTICA
Authors: Franca Greik Machado , Cruz Gilberto Saldanha da , Morais Renato Pissinati , Dias Alanna Kerlen Costa , Araujo Maria Eloisa da Silva , Moreira Lívia Martins , Soares André Luiz Faleiro
Published: September 2021

O intestino, há tempos, passou a ser estudado não apenas como um dos órgãos do sistema digestivo, mas também como peça fundamental na resposta imunológica. Ele abriga grande parte do tecido linfoide do ser humano. O tecido linfoide associado ao intestino é responsável por reconhecer agentes patogênicos e promover a devida resposta imune. Além do tecido linfoide, o intestino possui em sua mucosa uma grande diversidade de microrganismos, vivendo em simbiose com o ser humano. O conjunto de microrganismos é conhecido como microbiota intestinal e desempenha um papel fundamental na nutrição, na proteção e na homeostase intestinal. O desequilíbrio da microbiota intestinal, disbiose, vem sendo estudado como um dos principais fatores que possibilitam o desenvolvimento de diversas patologias intestinais e extra intestinais. A saúde da microbiota intestinal reflete diretamente na saúde do hospedeiro. Este trabalho é uma pesquisa exploratória baseada na revisão bibliográfica de artigos publicados do ano de 1995 a 2016 com o objetivo de demonstrar a importância de se manter a microbiota saudável, evidenciando seus mecanismos de atuação, além de descrever a sua ação imunomoduladora e os problemas decorrentes de seu desequilíbrio. Por fim, descrevendo a eficácia da utilização dos probióticos e simbióticos no tratamento e prevenção de doenças intestinais.
ATUAÇÃO DO PROFISSIONAL FARMACÊUTICO NA AUTOMEDICAÇÃO
Authors: Cordeiro Eduardo Martins , Abreu Thiago
Published: September 2021

Diante das responsabilidades impostas pela profissão, é nítida a importância do profissional farmacêutico participando ativamente da promoção de saúde. A OMS define a automedicação como a prática de ingerir medicamentos sem orientação de um médico ou farmacêutico. A prática da automedicação pode trazer consequências danosas ao organismo. Para construção desse trabalho foi utilizado método de revisão de literatura, descrevendo materiais coletados por meio das bases de dados: SciELO – Scientific Eletronic Library, Google Acadêmico, legislações, dissertações, Ministério da Saúde (MS) que datam do ano de 2000 a 2021. Objetiva-se nesse trabalho promover o uso racional dos medicamentos, através da atuação farmacêutica na automedicação.
DEUS EXISTE? UM ESTUDO PROBABILÍSTICO
Authors: Silva Charles Florentino da
Published: September 2021

O presente artigo tem por finalidade a investigação acerca da possibilidade da existência de Deus através de um olhar probabilístico, para isso será apresentado os conceitos da proporção áurea presentes na natureza, seguidas de deduções probabilísticas a cerca desse fenômeno.
INQUIETAÇÕES INTERCULTURAIS: UMA ANÁLISE NA MOTIVAÇÃO MIGRATÓRIA HAITIANA
Authors: Benetti Thayza Karolline de Souza , Duarte Rafael Pinto
Published: September 2021

A presente pesquisa busca interceptar, aplicar e explicar a mediação cultural (intercultural e multicultural) e a atuação dos agentes sociais e políticas públicas em conjunto com as organizações internacionais em prol da inserção de minorias na sociedade. Neste caso, sumarizando a razão do movimento de migração da população haitiana, bem como sua integração no Brasil, atrelando simultaneamente a importância da mediação no espectro da colonialidade do poder. Logo, as ideias apresentadas aglutinam o olhar internacionalista na inserção dos refugiados na sociedade brasileira ao reconhecimento da função do mediador sociocultural de acordo com Casa-Nova (2009), como o trabalho sendo “inerente à figura do mediador e da mediadora: conhecer para compreender, compreender para mediar, mediar para tornar possível a construção de diálogos ou de uma vivência não conflitual na perspectiva dos sujeitos-actores”.  Conclui-se, através da coleta de dados de entrevistas, como o Direito Internacional, o sistema da Organização das Nações Unidas (ONU) e o terceiro setor, exercem a manutenção dos direitos, da identidade cultural e dignidade dos migrantes e refugiados - com ênfase no Estado brasileiro e a recepção haitiana.
OS DESAFIOS DA FORMAÇÃO DOCENTE PARA O RECONHECIMENTO DOS ALUNOS COM ALTAS HABILIDADES/SUPERDOTAÇÃO
Authors: Oliveira Ana Carolina Alves Ramos de , Alves Ana Julia , Moraes Gisele Foresto , Oliveira Elimeire Alves de
Published: September 2021

O presente artigo tem como objetivo geral compreender a importância da formação docente para o reconhecimento dos alunos com Altas Habilidades/Superdotação, diante da necessidade de um tratamento diferenciado que eles possuem, direito reconhecido por lei, com vistas à equidade. Como objetivos específicos levantar a legislação que ampara esse direito, compreender o conceito de Altas Habilidades e/ou Superdotação; levantar quais os principais mitos e preconceitos que envolvem o assunto e que dificultam o trabalho docente, com vistas ao desenvolvimento das potencialidades desses alunos. Trata-se de uma pesquisa de natureza aplicada, com abordagem qualitativa, de fonte bibliográfica, por meio da leitura de autores que versam sobre o assunto, como  Alencar (2007);   Godoy et al. (2010); Perez  (2017); Freitas; Pérez (2012); Franson e Watzlawick (2016); Renzulli (2014); Virgolin (2014), Também será utilizada fonte documental, em que serão analisadas legislações importantes para a compreensão da trajetória das políticas públicas inclusivas como a Constituição Federal do Brasil (BRASIL, 1988); Lei de Diretrizes de Bases da Educação 9394/96 (BRASIL, 1996); Lei 13.234/15,  que tratam do atendimento dos alunos com altas habilidades ou superdotação na Educação Básica e no Ensino superior.
O USO DO CANABIDIOL EM PACIENTE COM EPILEPSIA
Authors: Pereira Patrick Gama , Pugliese Fabiana Sousa , Silva Michel Santos da , Andrade Leonardo Guimarães de
Published: September 2021

O uso da cannabis para o tratamento da epilepsia sempre teve papel de destaque no tratamento dos casos dessa doença, isso não acontecia por acaso. De acordo com um relatório de revisão crítica da Organização Mundial da Saúde (OMS), essa substância poderosa é benéfica para pessoas com doenças que afetam o sistema nervoso e as sinapses cerebrais. Esse reconhecimento se deve a um grande número de estudos que apontam para a eficácia dos canabinoides, que podem ser usados ​​como anticonvulsivantes e neuroprotetores. A epilepsia é uma doença que afeta o sistema nervoso central (SNC) e o cérebro. O sintoma mais óbvio são as convulsões, que podem ser clônus ou clônus tônico e, em alguns casos, podem causar perda de consciência. No Brasil, cerca de 1% a 2% da população sofre de epilepsia, que pode afetar pessoas de todas as idades. É uma das doenças mais comuns do sistema nervoso central. Embora o CBD não tenha sido 100% aprovado cientificamente para o tratamento da epilepsia, ele foi considerado seguro e eficaz. Isso porque o óleo de canabidiol é um dos medicamentos mais prescritos e apresenta vantagens muito relevantes em comparação com os medicamentos convencionais.
SISTEMA PRISIONAL E ADOECIMENTO PSÍQUICO DAS MULHERES EM PRIVAÇÃO DE LIBERDADE: UMA REVISÃO BIBLIOGRÁFICA
Authors: Pinheiro Jádia Alves , Barreto Robenilson Moura
Published: September 2021

O presente trabalho acadêmico teve como objetivo analisar as produções científicas no campo da saúde mental das mulheres encarceradas e como o sofrimento psíquico tem aparecido nessas produções nos últimos anos. Como metodologia utilizou-se a revisão de bibliografia narrativa através de E-books, em plataformas como sciELO, BDTD, BVS-PSI, Fundamentais para a coleta de dados. Como resultado observou-se que apesar das produções existentes, os estudos na área são poucos e não conseguem abarcar a totalidade de implicações relacionadas a promoção de saúde mental no ambiente prissional e que apesar dos desdobramentos da psicologia e outras áreas o sistema penitenciário dificulta a coleta de dados e aplicação de metodologias por se tratar de um ambiente hostil que promove inúmeras formas de violências.
TOXINA BOTULÍNICA APLICADA PARA FINS TERAPÊUTICOS
Authors: Xavier Elisângela Costa , Lobo Livia Cabral
Published: September 2021

Clostridium botulinum é um organismo gram-positivo estritamente anaeróbio e forma esporos, produz uma potente neurotoxina chamada Toxina Botulínica tipo A (TBA), que é eficaz para pacientes durante o tratamento e procedimentos. A qualidade de vida desempenha um papel extremamente eficaz e é um dos métodos não cirúrgicos mais utilizados no Brasil. Injetar intramuscularmente onde você deseja resultados, o TBA se liga a receptores terminais nos nervos motores, inibe a liberação de acetilcolina e, em última análise, evita a contração muscular, resultando em relaxamento muscular temporário. Portanto, foi usado clinicamente por Allan Scott, oftalmologista da Califórnia (EUA), para correção de estrabismo na década de 1980. Em seguida, ocorreram movimentos involuntários como blefaroespasmo e espasmo hemifacial, tornando-se a primeira escolha para o tratamento dessas doenças. Mais tarde, foi usado para distonia cervical, distonia espástica, distonia focal das mãos e pernas, distonia motora específica e tremor. Nos últimos anos, o escopo de indicações para o tratamento da toxina botulínica aumentou significativamente e agora é usado para tratar espasmos, programas de reabilitação, disfunção da bexiga ou do esfíncter anal, dores de cabeça tensionais e até mesmo como um tratamento cosmético para eliminar rugas faciais. A Toxina botulínica do tipo A também é usada como tratamento para enxaqueca crônica e hiperidrose e é uma opção de tratamento alternativo para cirurgia em certas condições patológicas.
A GESTÃO PATRIMONIAL NA ADMINISTRAÇÃO PÚBLICA: UM ESTUDO DE CASO NO CIEP 293 – WALMIR DE FREITAS MONTEIRO
Authors: Moraes Renato Alencar de
Published: September 2021

O intuito deste artigo é estudar o controle patrimonial dos bens na administração pública como um instrumento de Governança Pública. A Gestão Patrimonial voltada à administração pública tem por objetivo principal atender as demandas por materiais permanentes e de consumo com o intuito de viabilizar as diversas atividades desenvolvidas em uma determinada instituição. Como finalidades peculiares procurou-se entender os fundamentos da Administração Pública e delinear as metodologias, tecnologias e os recursos instituídos no controle patrimonial pelo ente Público. Desta forma, para aprofundar o conhecimento acerca do tema Gestão Patrimonial no setor público, esta pesquisa apresenta como objetivo geral analisar os procedimentos referentes à gestão patrimonial adotados pelo CIEP 293 – Walmir de Freitas Monteiro, com vistas ao desfazimento de bens inservíveis à luz do Decreto 9.373/18 e suas atualizações, e propor melhorias no processo em questão. Para tanto, utilizou-se uma pesquisa aplicada, com realização de entrevista com a diretora do Ciep para levantamento das informações.  Os resultados demonstram que o CIEP 293 atende parcialmente ao que determina o Decreto 9.373/18 no que se refere ao tratamento dos bens inservíveis, devendo a mesma adotar medidas corretivas visando o bom andamento das atividades da Gestão Patrimonial da Instituição.
A IMPORTÂNCIA DO ENSINO DE FILOSOFIA NO ENSINO MÉDIO
Authors: Silva Cicera Tenório da , Sapucaia Glauciany Deyvann Tenório de Almeida
Published: September 2021

Nosso objetivo a partir desta pesquisa é pensar a questão do Ensino da Filosofia e do filosofar, partindo de alguns pensamentos filosóficos que marcaram a reflexão sobre a Educação no século XX e neste início do século XXI, bem como apresentar o problema da experiência do homem na atualidade. O decurso desse trabalho e sua elaboração sustentam-se no estudo teórico-filosófico. A percepção de uma sociedade entregue à mentalidade pós-moderna tornou-se subsídio para a Filosofia e a Educação, exigindo e propondo a reflexão urgente sobre a banalização da vida, a subserviência ao consumismo desenfreado e a expropriação da experiência. Resgatando a antiga  relação entre a Filosofia e  a Pedagogia, nos propomos a pensar a experiência na vida e na Educação, especificamente uma experiência que possibilite também a reflexão dos estudantes frente à realidade em que vivem hoje; ou seja, pensamos na urgência de uma Educação que valorize novamente a reflexão filosófica por meio de uma experiência filosófica, tendo-a também como fim. Assim, nossa pesquisa problematiza o Ensino de Filosofia bem como aprofunda o tema da experiência, apresentando sua importância no momento presente. Assim, a Educação e Filosofia são aqui  apresentados como uma espécie de tripé formador da vida humana, pois carregam consigo a novidade, o desejo, o inesperado, que são também algumas condições para a experiência humana. Entretanto, essa formação exige a atenção constante, resistindo a imposições, ideologias e programações, resgatando o valor, a necessidade e a compreensão da experiência na atualidade.