bluuebunny/crossref_metadata_2025 huggingface dataset:
Beating the odds: a rare case of supracardiac total anomalous pulmonary venous return (TAPVR) in an adult patient
Authors: Talib Norain , Sayuti Khairil Amir , Abdullah Mohd Shafie , Mohd Zain Mohd Rizal
Published: March 2018

Total anomalous pulmonary venous return (TAPVR) is a rare congenital heart defect, and patients are usually symptomatic at a very young age. Survival to adulthood without surgical correction is extremely rare. We report a 33-year-old woman with a heart murmur and a history of a successful pregnancy. Echocardiogram revealed a large atrial septal defect with suspicious pulmonary vein anomaly. Chest radiograph demonstrated classical ‘snowman’ configuration. Cardiac catheterisation was consistent with anomalous pulmonary venous drainage. Cardiac CT confirmed supracardiac TAPVR, whereby all the pulmonary veins drain into the anomalous vein and finally to the superior vena cava. She remained asymptomatic and underwent a successful surgical repair.
Impact of a national QI programme on reducing electronic health record notifications to clinicians
Authors: Shah Tina , Patel-Teague Shilpa , Kroupa Laura , Meyer Ashley N D , Singh Hardeep
Published: March 2018

Background

Emerging evidence suggests electronic health record (EHR)-related information overload is a risk to patient safety. In the US Department of Veterans Affairs (VA), EHR-based ‘inbox’ notifications originally intended for communicating important clinical information are now cited by 70% of primary care practitioners (PCPs) to be of unmanageable volume. We evaluated the impact of a national, multicomponent, quality improvement (QI) programme to reduce low-value EHR notifications.

Methods

The programme involved three steps: (1) accessing daily PCP notification load data at all 148 facilities operated nationally by the VA; (2) standardising and restricting mandatory notification types at all facilities to a recommended list; and (3) hands-on training for all PCPs on customising and processing notifications more effectively. Designated leaders at each of VA’s 18 regional networks led programme implementation using a nationally developed toolkit. Each network supervised technical requirements and data collection, ensuring consistency. Coaching calls and emails allowed the national team to address implementation challenges and monitor effects. We analysed notification load and mandatory notifications preintervention (March 2017) and immediately postintervention (June–July 2017) to assess programme impact.

Results

Median number of mandatory notification types at each facility decreased significantly from 15 (IQR: 13–19) to 10 (IQR: 10–11) preintervention to postintervention, respectively (P<0.001). Mean daily notifications per PCP decreased significantly from 128 (SEM=4) to 116 (SEM=4; P<0.001). Heterogeneity in implementation across sites led to differences in observed programme impact, including potentially beneficial carryover effects.

Conclusions

Based on prior estimates on time to process notifications, a national QI programme potentially saved 1.5 hours per week per PCP to enable higher value work. The number of daily notifications remained high, suggesting the need for additional multifaceted interventions and protected clinical time to help manage them. Nevertheless, our project suggests feasibility of using large-scale ‘de-implementation’ interventions to reduce unintended safety or efficiency consequences of well-intended electronic communication systems.
Continuous residual reinforcement learning for traffic signal control optimization
Authors: Aslani Mohammad , Seipel Stefan , Wiering Marco
Published: March 2018

Traffic signal control can be naturally regarded as a reinforcement learning problem. Unfortunately, it is one of the most difficult classes of reinforcement learning problems owing to its large state space. A straightforward approach to address this challenge is to control traffic signals based on continuous reinforcement learning. Although they have been successful in traffic signal control, they may become unstable and fail to converge to near-optimal solutions. We develop adaptive traffic signal controllers based on continuous residual reinforcement learning (CRL-TSC) that is more stable. The effect of three feature functions is empirically investigated in a microscopic traffic simulation. Furthermore, the effects of departing streets, more actions, and the use of the spatial distribution of the vehicles on the performance of CRL-TSCs are assessed. The results show that the best setup of the CRL-TSC leads to saving average travel time by 15% in comparison to an optimized fixed-time controller.
The effect of the density of candidate roads on solutions in tactical forest planning
Authors: Naderializadeh Nader , Crowe Kevin A.
Published: March 2018

In this paper, we inquire into whether, and by how much, the use in tactical planning of a dense set versus a sparse set of candidate roads can reduce the two major costs (construction and transportation) of forest operations. This inquiry is conducted by using an optimal road location model to generate dense and sparse sets of candidate roads for three different problem instances. These problem instances were then solved using a mixed integer representation of the integrated tactical planning problem. The results show that the use of a dense set versus a sparse set of candidate roads, for all three problem instances, yielded solutions with a mean decrease in transportation and construction costs of 34.34% and 6.94%, respectively. The mean increase in revenue was 1.06%, and the mean increase in the objective function value (revenue minus the total road construction and transportation costs) was 5.62%. In addition, the mapped solutions reveal the spatial attributes of a lower versus a higher cost road network: straighter roads and more efficiently located forks within the road network. These results were obtained to illustrate how reductions in the costs of transportation and road construction can be achieved in tactical planning.
Transovarial transmission of dengue 1 virus in Aedes aegypti larvae: real-time PCR analysis in a Brazilian city with high mosquito population density
Authors: Moraes Alexsander , Cortelli Filipe C. , Miranda Taís B. , Aquino Davi R. , Cortelli José R. , Guimarães Maria Isabel A. , Costa Fernando O. , Cortelli Sheila C.
Published: March 2018

Transovarial transmission is among the reported factors able to influence environmental maintenance of dengue virus (DENV). Endemic areas with active transmission of dengue are suitable for studying transovarial transmission. Brazil is a country where dengue is endemic and where DENV-1 is the most common disease-related virus serotype. This study aimed to identify transovarial transmission of DENV-1 in Aedes aegypti larvae by reverse-transcriptase nested real-time polymerase chain reaction. Between March and October 2016, Culicidae larvae were collected using traps in 3 locations in Taubaté, São Paulo, Brazil, which has a high occurrence of dengue. The collected larvae were sacrificed in the 3rd or 4th larval stage, classified, and stored at –20 °C. The A. aegypti larvae samples (n = 910) were separated into 91 pools of 10 specimens each from which RNA was extracted, reverse transcribed into cDNA, and analyzed by nested qPCR. None of the pools tested positive for DENV-1. Due to the absence of detectable virus in the evaluated samples, we concluded that transovarial transmission may not be the primary mechanism for maintenance of DENV-1 in this particular environment.
Transforming growth factor-β1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways
Authors: Ongali Brice , Nicolakakis Nektaria , Tong Xin-Kang , Lecrux Clotilde , Imboden Hans , Hamel Edith
Published: March 2018

Transgenic mice constitutively overexpressing the cytokine transforming growth factor-β1 (TGF-β1) (TGF mice) display cerebrovascular alterations as seen in Alzheimer’s disease (AD) and vascular cognitive impairment and dementia (VCID), but no or only subtle cognitive deficits. TGF-β1 may exert part of its deleterious effects through interactions with angiotensin II (AngII) type 1 receptor (AT1R) signaling pathways. We test such interactions in the brain and cerebral vessels of TGF mice by measuring cerebrovascular reactivity, levels of protein markers of vascular fibrosis, nitric oxide synthase activity, astrogliosis, and mnemonic performance in mice treated (6 months) with the AT1R blocker losartan (10 mg/kg per day) or the angiotensin converting enzyme inhibitor enalapril (3 mg/kg per day). Both treatments restored the severely impaired cerebrovascular reactivity to acetylcholine, calcitonin gene-related peptide, endothelin-1, and the baseline availability of nitric oxide in aged TGF mice. Losartan, but not enalapril, significantly reduced astrogliosis and cerebrovascular levels of profibrotic protein connective tissue growth factor while raising levels of antifibrotic enzyme matrix metallopeptidase-9. Memory was unaffected by aging and treatments. The results suggest a pivotal role for AngII in TGF-β1-induced cerebrovascular dysfunction and neuroinflammation through AT1R-mediated mechanisms. Further, they suggest that AngII blockers could be appropriate against vasculopathies and astrogliosis associated with AD and VCID.
Critical snow density threshold for Dall’s sheep (Ovis dalli dalli)
Authors: Sivy Kelly J. , Nolin Anne W. , Cosgrove Christopher L. , Prugh Laura R.
Published: March 2018

Snow cover can significantly impact animal movement and energetics, yet few studies have investigated the link between physical properties of snow and energetic costs. Quantification of thresholds in snow properties that influence animal movement are needed to help address this knowledge gap. Recent population declines of Dall’s sheep (Ovis dalli dalli Nelson, 1884) could be due in part to changing snow conditions. We examined the effect of snow density, snow depth, and snow hardness on sinking depths of Dall’s sheep tracks encountered in Wrangell–St. Elias National Park and Preserve, Alaska. Snow depth was a poor predictor of sinking depths of sheep tracks (R2 = 0.02, p = 0.38), as was mean weighted hardness (R2 = 0.09, p = 0.07). Across competing models, top layer snow density (0–10 cm) and sheep age class were the best predictors of track sink depths (R2 = 0.58). Track sink depth decreased with increasing snow density, and the snowpack supported the mass of a sheep above a density threshold of 329 ± 18 kg/m3 (mean ± SE). This threshold could aid interpretation of winter movement and energetic costs by animals, thus improving our ability to predict consequences of changing snowpack conditions on wildlife.
Genome-wide identification and analysis of elongase of very long chain fatty acid genes in the silkworm, Bombyx mori
Authors: Zuo Weidong , Li Chunlin , Luan Yue , Zhang Hao , Tong Xiaoling , Han Minjin , Gao Rui , Hu Hai , Song Jiangbo , Dai Fangyin , Lu Cheng
Published: March 2018

Very long chain fatty acids (VLCFAs), such as sphingolipids, are components of cellular lipids, which are essential for cell proliferation. Mutations in the genes that encode proteins participating in VLCFA biosynthesis may cause inherited diseases, such as macular degeneration. Elongases of very long chain fatty acid (ELOVL) are enzymes that are involved in the biosynthesis of VLCFAs. Here, a total of 13 ELOVL genes, distributed across three chromosomes, were identified in the silkworm genome; all the ELOVL members contain a distinct ELO domain and a conserved HXXHH motif. Phylogenetic reconstruction was performed to analyze the evolutionary relationships among different species and to predict gene functions. The 13 ELOVL genes were assigned to the ELOVL3/6, ELOVL1/7, and ELOVL4 clades. Microarray and semiquantitative PCR analyses indicated that these genes are differentially expressed among various tissues, in turn suggesting functional divergence in the growth and development of each tissue. Further investigation showed that the expression level of the BGIBMGA000424 gene is significantly negatively correlated with the cocoon-shell weight among different silkworm strains. Taken together, the present study is the first comprehensive analysis of ELOVL genes in silkworm, and the results may serve as a foundation for further analysis of the physiological functions of ELOVL genes in silkworm.
Rogue waves in multiple-solitons–inelastic collisions — The complex Sharma–Tasso–Olver equation
Authors: Abdel-Gawad H. I. , Tantawy M.
Published: March 2018

Very recently, a mechanism to the formation of rogue waves (RWs) has been proposed by the authors. In this paper, the formation of RWs in case of the complex Sharma–Tasso–Olver (STO) equation is studied. In the STO equation, one, two and three-soliton solutions are obtained. Due to the inelastic collisions, these soliton waves are fused to one. Under the free parameters constraint this behavior do occurs. The mechanism of formation of RWs is due to the collisions of solitons and multi-periodic waves (like spectral band). These RWs as giant waves, which may be very sharp or chaotic are similar to RWs in laser. The work is done here by using the generalized unified method (GUM).
Experimental investigations on characteristics of boundary layer and control of transition on an airfoil by AC-DBD
Authors: Geng Xi , Shi Zhiwei , Cheng Keming , Dong Hao , Zhao Qun , Chen Sinuo
Published: March 2018

Plasma-based flow control is one of the most promising techniques for aerodynamic problems, such as delaying the boundary layer transition. The boundary layer’s characteristics induced by AC-DBD plasma actuators and applied by the actuators to delay the boundary layer transition on airfoil at Ma = 0.3 were experimentally investigated. The PIV measurement was used to study the boundary layer’s characteristics induced by the plasma actuators. The measurement plane, which was parallel to the surface of the actuators and 1 mm above the surface, was involved in the test, including the perpendicular plane. The instantaneous results showed that the induced flow field consisted of many small size unsteady vortices which were eliminated by the time average. The subsequent oil-film interferometry skin friction measurement was conducted on a NASA SC(2)-0712 airfoil at Ma = 0.3. The coefficient of skin friction demonstrates that the plasma actuators successfully delay the boundary layer transition and the efficiency is better at higher driven voltage.
Green synthesis of nanocrystalline α-Al2O3powders by both wet-chemical and mechanochemical methods
Authors: Gao Huiying , Li Zhiyong , Zhao Peng
Published: March 2018

Nanosized [Formula: see text]-Al2O3powders were prepared with AlCl[Formula: see text]6H2O and NH4HCO3as raw materials by both wet-chemical and mechanochemical methods, through the synthesis of the ammonium aluminum carbonate hydroxide (AACH) precursor followed by calcination. The environmentally benign starch was used as an effective dispersant during the preparation of nanocrystalline [Formula: see text]-Al2O3powders. X-ray diffraction (XRD), thermogravimetric differential thermal analysis (TG-DTA), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were employed to characterize the precursor AACH and products. The results show that nanosized spherical [Formula: see text]-Al2O3powders without hard agglomeration and with particle size in the range of 20–40 nm can be obtained by the two methods. Comparing the two “green” processes, the mechanochemical method has better prospects for commercial production.
Tunable plasmonic filter based on graphene-layered waveguide
Authors: Feng Yuncai , Liu Youwen , Shi Yaoyao , Teng Jinghua
Published: March 2018

We propose a tunable band-stop plasmonic filter based on monolayer graphene with different thickness of structure, and the corresponding transmission characteristic is numerically investigated by using finite-difference time-domain (FDTD) method. The results show that the proposed filter can achieve a broad stopband that can be tuned by various physical parameters such as the chemical potential of graphene, the thickness of packing layers and so on. Our studies may be important for designing tunable optical filter, the fabrication of nano-integrated plasmonic circuits and the refractive index sensitive sensors.
When Two Rights Make a Wrong: The Evolutionary Genetics of Plant Hybrid Incompatibilities
Authors: Fishman Lila , Sweigart Andrea L.
Published: March 2018

Hybrids between flowering plant species often exhibit reduced fitness, including sterility and inviability. Such hybrid incompatibilities create barriers to genetic exchange that can promote reproductive isolation between diverging populations and, ultimately, speciation. Additionally, hybrid breakdown opens a window into hidden molecular and evolutionary processes occurring within species. Here, we review recent work on the mechanisms and origins of hybrid incompatibility in flowering plants, including both diverse genic interactions and chromosomal incompatibilities. Conflict and coevolution among and within plant genomes contributes to the evolution of some well-characterized genic incompatibilities, but duplication and drift also play important roles. Inversions, while contributing to speciation by suppressing recombination, rarely cause underdominant sterility. Translocations cause severe F1sterility by disrupting meiosis in heterozygotes, making their fixation in outcrossing sister species a paradox. Evolutionary genomic analyses of both genic and chromosomal incompatibilities, in the context of population genetic theory, can explicitly test alternative scenarios for their origins.
Advanced Endoscopic Navigation: Surgical Big Data, Methodology, and Applications
Authors: Luo Xiongbiao , Mori Kensaku , Peters Terry M.
Published: March 2018

Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs within the body cavity. Endoscopy may also be used to guide the introduction of certain items (e.g., stents) into the body. Endoscopic navigation systems seek to integrate big data with multimodal information (e.g., computed tomography, magnetic resonance images, endoscopic video sequences, ultrasound images, external trackers) relative to the patient's anatomy, control the movement of medical endoscopes and surgical tools, and guide the surgeon's actions during endoscopic interventions. Nevertheless, it remains challenging to realize the next generation of context-aware navigated endoscopy. This review presents a broad survey of various aspects of endoscopic navigation, particularly with respect to the development of endoscopic navigation techniques. First, we investigate big data with multimodal information involved in endoscopic navigation. Next, we focus on numerous methodologies used for endoscopic navigation. We then review different endoscopic procedures in clinical applications. Finally, we discuss novel techniques and promising directions for the development of endoscopic navigation.
Potential Use of Essential Oil Isolated fromCleistocalyx operculatusLeaves as a Topical Dermatological Agent for Treatment of Burn Wound
Authors: Tran Gia-Buu , Le Nghia-Thu Tram , Dam Sao-Mai
Published: March 2018

Several herbal remedies have been used as topical agents to cure burn wound, one of the most common injuries in worldwide. In this study, we investigated the potential use ofCleistocalyx operculatusessential oil to treat the burn wound. We identified a total of 13 bioactive compounds of essential oil, several of which exhibited the anti-inflammatory and antimicrobial activities. Furthermore, the essential oil showed the antibacterial effect againstS. aureusbut not withP. aeruginosa.The supportive effect of essential oil on burn wound healing process also has been proven. Among three groups of mice, wound contraction rate of essential oil treated group (100%) was significantly higher than tamanu oil treated (79%) and control mice (71%) after 20 days (0.22±0.03versus0.31±0.02 cm2, resp.,p<0.05). Histological studies revealed that burn wounds treated with essential oil formed a complete epidermal structure, thick and neatly arranged fibers, and scattered immune cells in burn wound. On the contrary, saline treated burn wound formed uneven epidermal layer with necrotic ulcer, infiltration of immune cells, and existence of granulation tissue. This finding demonstratedCleistocalyx operculatusessential oil as promising topical dermatological agent to treat burn wound.
Fast Specimen Boundary Tracking and Local Imaging with Scanning Probe Microscopy
Authors: Wen Yongbing , Song Jianmin , Fan Xinjian , Hussain Danish , Zhang Hao , Xie Hui
Published: March 2018

An efficient and adaptive boundary tracking method is developed to confine area of interest for high-efficiency local scanning. By using a boundary point determination criterion, the scanning tip is steered with a sinusoidal waveform while estimating azimuth angle and radius ratio of each boundary point to accurately track the boundary of targets. A local scan region and path are subsequently planned based on the prior knowledge of boundary tracking to reduce the scan time. Boundary tracking and local scanning methods have great potential not only for fast dimension measurement but also for sample surface topography and physical characterization, with only scanning region of interest. The performance of the proposed methods was verified by using the alternate current mode scanning ion-conductance microscopy, tapping, and PeakForce modulation atomic force microscopy. Experimental results of single/multitarget boundary tracking and local scanning of target structures with complex boundaries demonstrate the flexibility and validity of the proposed method.
Quantitative Approach Based on Wearable Inertial Sensors to Assess and Identify Motion and Errors in Techniques Used during Training of Transfers of Simulated c-Spine-Injured Patients
Authors: Lebel Karina , Chenel Vanessa , Boulay John , Boissy Patrick
Published: March 2018

Patients with suspected spinal cord injuries undergo numerous transfers throughout treatment and care. Effective c-spine stabilization is crucial to minimize the impacts of the suspected injury. Healthcare professionals are trained to perform those transfers using simulation; however, the feedback on the manoeuvre is subjective. This paper proposes a quantitative approach to measure the efficacy of the c-spine stabilization and provide objective feedback during training. Methods. 3D wearable motion sensors are positioned on a simulated patient to capture the motion of the head and trunk during a training scenario. Spatial and temporal indicators associated with the motion can then be derived from the signals. The approach was developed and tested on data obtained from 21 paramedics performing the log-roll, a transfer technique commonly performed during prehospital and hospital care. Results. In this scenario, 55% of the c-spine motion could be explained by the difficulty of rescuers to maintain head and trunk alignment during the rotation part of the log-roll and their difficulty to initiate specific phases of the motion synchronously. Conclusion. The proposed quantitative approach has the potential to be used for personalized feedback during training sessions and could even be embedded into simulation mannequins to provide an innovative training solution.
Refraction and Ocular Biometry of Preschool Children in Shanghai, China
Authors: Zhang Luoli , He Xiangui , Qu Xiaomei , You Xiaofang , Wang Bingjie , Shi Huijing , Tan Hui , Zou Haidong , Zhu Jianfeng
Published: March 2018

Purpose. To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China.Methods. A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 kindergartens in Jiading District and 10 kindergartens in Xuhui District, with a probability proportionate to size. The children underwent comprehensive eye examinations, including cycloplegic refraction and biometric measurements. Myopia, hyperopia, astigmatism were defined as spherical equivalent (SE) ≤ −0.50 D, SE ≥ +2.00 D, and cylindrical diopters ≤ −1.00 D.Results. The mean SE for 3- to 6-year-old children was +1.20 D (standard deviation [SD] 1.05), and the mean axial length (AL) was 22.29 mm (SD 0.73). The overall prevalence of myopia and astigmatism was 3.7% and 18.3%, respectively. No difference in prevalence of astigmatism was found across age groups. There was a statistically significant association between lower cylindrical diopters and higher spherical diopters (Spearman’s correlation: −0.21,P<0.001).Conclusion. Chinese children aged 3 to 6 years in the Shanghai area were mostly mildly hyperopic, with a low prevalence of myopia. Refractive astigmatism for children may be relatively stable throughout the preschool stage. Astigmatism was significantly associated with refractive error.
A Mathematical Model for Top Nutation Based on Inertial Forces of Distributed Masses
Authors: Usubamatov Ryspek , Omorova Albina
Published: March 2018

The main property of gyroscopic devices is maintaining the axis of a spinning rotor, a mathematical model formulated on the principle of the change in the angular momentum. This principle is used for mathematical modeling of the motions of a top at known publications. Nevertheless, practical tests of gyroscopic devices do not correspond to this analytical approach. Recent investigations have demonstrated that the origin of gyroscope properties is more complex than that represented in known publications. The applied torque on a gyroscope produces internal torques of the spinning rotor based on the action of the several inertial forces. These forces are the centrifugal, Coriolis, and common inertial forces as well as the change in the angular momentum generated by the mass elements and center-mass of the spinning rotor. The action of these torques manifests itself in the resistance and precession torques of the gyroscopic devices. These inertial torques act simultaneously and interdependently around two axes and represent the fundamental principles of the gyroscope theory. The new inertial torques enable deriving mathematical models for the motions of well-known top that is the simplest form of gyroscopic devices. The novelty of the work is mathematical models for the motions of the top based on action of eight inertial forces acting around its two axes. The obtained mathematical models for the top nutation and self-stabilization are represented in terms of machine dynamics and vibration analysis. The new analytical approach for motions of the well-balanced top and top with eccentricity of the center-mass definitely responds to the practical results.
Percutaneous Injection of Strontium Containing Hydroxyapatite versus Polymethacrylate Plus Short-Segment Pedicle Screw Fixation for Traumatic A2- and A3/AO-Type Fractures in Adults
Authors: Korovessis Panagiotis , Mpountogianni Eva , Syrimpeis Vasileios , Baikousis Andreas , Tsekouras Vasileios
Published: March 2018

Introduction. Polymethacrylate (PMMA) is commonly used in vertebroplasty and balloon kyphoplasty, but its use has been associated with complications. This study tests three hypotheses: (1) whether strontium hydroxyapatite (Sr-HA) is equivalent to PMMA for restoring thoracolumbar vertebral body fractures, (2) whether the incidence of PMMA leakage is similar to that of Sr-HA leakage, and (3) whether Sr-HAis is resorbed and substituted by new vertebral bone. Materials and Methods. Two age- and sex-matched groups received short percutaneous pedicle screw fixation plus PEEK implant (Kiva, VCF Treatment System, Benvenue Medical, Santa Clara, CA, USA) filled with either Sr-HA (Group A) or PMMA (Group B) after A2- and A3/AO-type thoracolumbar vertebral body fractures. The Visual Analog Scale (VAS) score and imaging parameters, which included segmental kyphosis angle (SKA), vertebral body height ratios (VBHr), spinal canal encroachment (SCE), bone cement leakage, and Sr-HA resorption, were compared between the two groups. Results. The average follow-up was 28 months. No differences in VAS scores between Groups A and B were observed at baseline. Baseline back pain in both groups improved significantly three months postoperatively. Anterior, middle, and posterior VBHr did not differ between the two groups at any time point. SKA was improved insignificantly in both groups. SCE decreased insignificantly in both groups on 12-month follow-up using computed tomography (CT). PMMA leakage was observed in one patient, while no Sr-HA paste leakages occurred. Sr-HA resorption and replacement with vertebral bone were observed, and no new fractures were observed. Conclusions. As all hypotheses were confirmed, the authors recommend the use of Sr-HA instead of PMMA in traumatic spine fractures, although more patients and longer follow-up will be needed to strengthen these results. This trial is registered with NCT03431519.
A Security Monitoring Method Based on Autonomic Computing for the Cloud Platform
Authors: Zhang Jingjie , Wu Qingtao , Zheng Ruijuan , Zhu Junlong , Zhang Mingchuan , Liu Ruoshui
Published: March 2018

With the continuous development of cloud computing, cloud security has become one of the most important issues in cloud computing. For example, data stored in the cloud platform may be attacked, and its security is difficult to be guaranteed. Therefore, we must attach weight to the issue of how to protect the data stored in the cloud. To protect data, data monitoring is a necessary process. Based on autonomic computing, we develop a cloud data monitoring system on the cloud platform, monitoring whether the data is abnormal in the cycle and analyzing the security of the data according to the monitored results. In this paper, the feasibility of the scheme can be verified through simulation. The results show that the proposed method can adapt to the dynamic change of cloud platform load, and it can also accurately evaluate the degree of abnormal data. Meanwhile, by adjusting monitoring frequency automatically, it improves the accuracy and timeliness of monitoring. Furthermore, it can reduce the monitoring cost of the system in normal operation process.
Numerical Simulation for a Three-Dimensional Air Pollution Measurement Model in a Heavy Traffic Area under the Bangkok Sky Train Platform
Authors: Suebyat Kewalee , Pochai Nopparat
Published: March 2018

Air pollutant levels in Bangkok are generally high in street tunnels. They are particularly elevated in almost closed street tunnels such as an area under the Bangkok sky train platform with high traffic volume where dispersion is limited. There are no air quality measurement stations in the vicinity, while the human population is high. In this research, the numerical simulation is used to measure the air pollutant levels. The three-dimensional air pollution measurement model in a heavy traffic area under the Bangkok sky train platform is proposed. The finite difference techniques are employed to approximate the modelled solutions. The vehicle air pollutant emission due to the high traffic volume is mathematically assumed by the pollutant sources term. The simulation is also considered in averaged and moving pollutant sources due to manner vehicle emission. The proposed approximated air pollutant concentration indicators can be replaced by user required gaseous pollutants indices such as NOx, SO2, CO, and PM2.5.
A Case of Pacemaker Endocarditis Caused by Aerococcus urinae
Authors: Samuelsson Sandra , Kennergren Charles , Rasmussen Magnus
Published: March 2018

Background. Aerococcus urinae has lately been acknowledged as a cause of infective endocarditis (IE) especially in older males with underlying urinary tract disorders. In this population, cardiac implanted electronical devices (CIED) are not uncommon, but despite the capacity of A. urinae to form biofilm in vitro, no cases of aerococcal CIED infections have been reported to date. Case Presentation. An 84-year-old male with pacemaker was admitted with dysuria one month after a transurethral procedure for urinary bladder cancer. A. urinae was isolated from urine and blood. Transesophageal echocardiography (TEE) was without signs of vegetation on valves or pacing cables. The patient was treated with a twelve-day course of β-lactam antibiotics. Forty days after the initial admission, the patient was readmitted due to malaise, general pain of the joints, chills, and renewed blood cultures grew A. urinae. TEE demonstrated a 10 × 5 mm vegetation on either the tricuspid valve or one of the pacing cables. The pacemaker system was completely removed and demonstrated macroscopic signs of infection. A temporary system was implanted, and after 14 days of penicillin G treatment, a new system permanent system was implanted. Total treatment time was 40 days. Recovery was uneventful. Conclusion. This report demonstrates that A. urinae can cause CIED infection. In patients with A. urinae bacteremia and a CIED, this risk must be considered, especially if bacteremia reoccurs.
Effects of Tibetan Music on Neuroendocrine and Autonomic Functions in Patients Waiting for Surgery: A Randomized, Controlled Study
Authors: Cotoia Antonella , Dibello Floriana , Moscatelli Fiorenzo , Sciusco Alberto , Polito Pietro , Modolo Alberto , Gallo Crescenzio , Cibelli Giuseppe , Cinnella Gilda
Published: March 2018

Background. The aim of this study was to investigate the effects of listening to Tibetan music on anxiety and endocrine, autonomic, cognitive responses in patients waiting for urologic surgery.Methods. Sixty patients waiting for surgery were enrolled to the study. They were randomized in music (M) and control (C) groups. The M group listened to a low-frequency Tibetan music for 30 min (T0–T30) through headphones, and the C group wore headphones with no sound. The State Trait Anxiety Inventory Questionnaire (STAI) Y-1 was administered at T0and T30. Normalized low (LFnu) and high frequencies (HFnu) of heart rate variability, LF/HF ratio, and galvanic skin response (GRS) data were analyzed at T0, T10, T20, T30, and T35. The salivaryα-amylase (sAA) samples were collected at T0, T35, and T45.Results. In the M group, the STAI Y-1 score decreased at T30versus baselinep<0.001, sAA levels decreased at T35versus T0p=0.004, and GSR remained unchanged. In the C group, the STAI Y-1 score remained unchanged, sAA level increased at T35versus T0p<0.001, and GSR slightly increased at T35versus baselinep=0.359. LFnu was lower, and HFnu was significantly higher (T10–T30) in M versus C group. Mean LF/HF ratio slightly reduced in the M group.Conclusions. Our results suggest that preoperative listening to relaxing Tibetan music might be a useful strategy to manage preoperative anxiety.
Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review
Authors: Müller Susanne , Oberle Doris , Drechsel-Bäuerle Ursula , Pavel Jutta , Keller-Stanislawski Brigitte , Funk Markus B.
Published: March 2018

Background: Benefits and risks of liberal and restrictive transfusion regimens are under on-going controversial discussion. This systematic review aimed at assessing both regimens in terms of pre-defined outcomes with special focus on patients undergoing major orthopaedic surgery. Methods: We performed a literature search for mortality, morbidity and related outcomes following peri-operative blood transfusion in patients with major orthopaedic surgery in electronic databases. Combined outcome measure estimates were calculated within the scope of meta-analyses including randomised clinical trials comparing restrictive versus liberal blood transfusion regimens (e.g. MH risk ratio, Peto odds ratio). Results: A total of 880 publications were identified 15 of which were finally included (8 randomised clinical trials (RCTs) with 3,693 patients and 6 observational studies with 4,244,112 patients). Regarding RCTs, no significant differences were detected between the transfusion regimes for all primary outcomes (30-day mortality, thromboembolic events, stroke/transitory ischaemic attack, myocardial infarction, wound infection and pneumonia) and a secondary outcome (length of hospital stay), whereas there was a significantly reduced risk of receiving at least one red blood concentrate under a restrictive regimen. Conclusion: The results of this systematic review do not suggest an increased risk associated with either a restrictive or a liberal transfusion regimen in patients undergoing major orthopaedic surgery.
Influence of Sleep Stage on LH Pulse Initiation in the Normal Late Follicular Phase and in Polycystic Ovary Syndrome
Authors: Lu Christine , Hutchens Eleanor G. , Farhy Leon S. , Bonner Heather G. , Suratt Paul M. , McCartney Christopher R.
Published: March 2018

Objective: During the early follicular phase, sleep-related luteinizing hormone (LH) pulse initiation is positively associated with brief awakenings but negatively associated with rapid eye movement (REM) sleep. The relationship between sleep architecture and LH pulse initiation has not been assessed in other cycle stages or in women with polycystic ovary syndrome (PCOS). Design and Methods: We performed concomitant frequent blood sampling (LH pulse analysis) and polysomnography on 8 normal women (cycle day 7–11) and 7 women with PCOS (at least cycle day 7). Results: In the normal women, the 5 min preceding LH pulses contained more wake epochs and fewer REM epochs than the 5 min preceding randomly determined time points (wake: 22.3 vs. 9.1%, p = 0.0111; REM: 4.4 vs. 18.8%, p = 0.0162). However, LH pulse initiation was not related to wake or REM epochs in PCOS; instead, the 5 min preceding LH pulses contained more slow-wave sleep (SWS) than the 5 min before random time points (20.9 vs. 6.7%, p = 0.0089). Compared to the normal subjects, the women with PCOS exhibited a higher REM-associated LH pulse frequency (p = 0.0443) and a lower proportion of wake epochs 0–5 min before LH pulses (p = 0.0205). Conclusions: Sleep-related inhibition of LH pulse generation during the later follicular phase is normally weakened by brief awakenings and strengthened by REM sleep. In women with PCOS, LH pulse initiation is not appropriately discouraged by REM sleep and may be encouraged by SWS; these abnormalities may contribute to a high sleep-related LH pulse frequency in PCOS.
Ruptura e reencontros entre cartografia e arte e seus desdobramentos na educação geográfica contemporânea
Authors: Girardi Gisele
Published: March 2018

A incorporação parcial de conhecimentos cartográficos no âmbito da cultura geográfica escolar brasileira promoveu um enrijecimento nas formas de se produzir geografia com mapas. Uma das possibilidades de entendimento da cartografia e dos mapas tem sido considerada a única possível, o que está na origem do forte caráter prescritivo que assumiu o conteúdo cartográfico no âmbito escolar. Serão analisados elementos da origem e disseminação de uma estética utilitária para os mapas que sustenta o referido enrijecimento, bem como serão apresentadas algumas discussões atuais sobre cartografia e arte que possam contribuir com o necessário repensar da cartografia na educação geográfica contemporânea.
Paisagens de névoa e neblina: a imagem literária de paisagens do medo
Authors: Guimarães Solange Lima
Published: March 2018

Neste artigo buscamos o sentido da concretude e do simbólico concernentes às paisagens experienciadas pelos ciganos nos campos de concentração e extermínio, durante o período da II Guerra, revelando a percepção de uma topofobia. A experiência ambiental dos ciganos sempre foi constituída por sobressaltos em todos os caminhos (objetivos e subjetivos): a paisagem do medo é novamente instalada diante das incertezas, morte e perplexidades destas populações.
Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase)
Authors: Etwebi Zienab , Landesberg Gavin , Preston Kyle , Eguchi Satoru , Scalia Rosario
Published: March 2018

MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO remain though largely elusive. Calpain is a calcium-dependent protease expressed in the vascular wall. Activation of calpains has been implicated in inflammatory disorders of the vasculature. Using endothelial cells and genetically modified mice, this study identifies the µ-calpain isoform as novel downstream signaling target of MPO in endothelial dysfunction. Mouse lung microvascular endothelial cells were stimulated with 10 nmol/L MPO for 180 minutes. MPO denitrosylated µ-calpain C-terminus domain, and time dependently activated µ-calpain, but not the m-calpain isoform. MPO also reduced Thr
172
AMPK (AMP-activated protein kinase) and Ser
1177
eNOS (endothelial nitric oxide synthase) phosphorylation via upregulation of PP2A (protein phosphatase 2) expression. At the functional level, MPO increased endothelial VCAM-1 (vascular cell adhesion molecule 1) abundance and the adhesion of leukocytes to the mouse aorta. In MPO-treated endothelial cells, pharmacological inhibition of calpain activity attenuated expression of VCAM-1 and PP2A, and restored Thr
172
AMPK and Ser
1177
eNOS phosphorylation. Compared with wild-type mice, µ-calpain deficient mice experienced reduced leukocyte adhesion to the aortic endothelium in response to MPO. Our data first establish a role for calpain in the endothelial dysfunction and vascular inflammation of MPO. The MPO/calpain/PP2A signaling pathway may provide novel pharmacological targets for the treatment of inflammatory vascular disorders.
Radioimmunoscintigraphy of Tumors Autocrine for Human Met and Hepatocyte Growth Factor/Scatter Factor
Authors: Hay Rick V. , Cao Brian , Skinner R. Scot , Wang Ling-Mei , Su Yanli , Resau James H. , Woude George F. Vande , Gross Milton D.
Published: March 2018

Inappropriate expression of the c-met-protooncogene product (Met) and/or of its ligand, hepatocyte growth factor/scatter factor (HGF/SF), has been correlated with poor prognosis in a variety of human solid tumors. We are developing animal models for nuclear imaging of Met and HGF/SF expression in tumors in vivo. We radioiodinated a mixture of monoclonal antibodies (MAbs) that bind to human HGF/SF and to the external ligand-binding domain of human Met, and then injected the I-125-MAb mixture intravenously into mice bearing tumors either autocrine for human HGF/SF and human Met or autocrine-paracrine for murine HGF/SF and murine Met. Serial total body gamma camera images were obtained, and regional activity was determined by quantitative region-of-interest (ROI) analysis. Tumors autocrine for human HGF/SF and Met demonstrated significantly more rapid uptake and more rapid clearance of the I-125-MAb mixture than tumors expressing one or both murine homologues, reaching a mean tumor to total body activity ratio of > 0.3 by 1 day postinjection. We conclude that radioimmunodetection of tumors autocrine for human HGF/SF and Met is feasible with an I-125-MAb mixture reactive against the ligand-receptor pair.
Ratio Imaging of Enzyme Activity Using Dual Wavelength Optical Reporters
Authors: Kircher Moritz F. , Josephson Lee , Weissleder Ralph
Published: March 2018

The design of near-infrared fluorescent (NIRF) probes that are activated by specific proteases has, for the first time, allowed enzyme activity to be imaged in vivo. In the current study, we report on a method of imaging enzyme activity using two fluorescent probes that, together, provide improved quantitation of enzymatic activity. The method employs two chemically similar probes that differ in their degradability by cathepsin B. One probe consists of the NIRF dye Cy5.5 attached to a particulate carrier, a crosslinked iron oxide nanoparticle (CLIO), through cathepsin B cleavable l-arginyl peptides. A second probe consists of Cy3.5 attached to a CLIO through proteolytically resistant d-arginyl peptides. Using mixtures of the two probes, we have shown that the ratio of Cy5.5 to Cy3.5 fluorescence can be used to determine levels of cathepsin B in the environment of nanoparticles with macrophages in suspension. After intravenous injection, tissue fluorescence from the nondegradable Cy3.5–d-arginyl probe reflected nanoparticle accumulation, while fluorescence of the Cy5.5–l-arginyl probe was dependent on both accumulation and activation by cathepsin B. Dual wavelength ratio imaging can be used for the quantitative imaging of a variety of enzymes in clinically important settings, while the magnetic properties of the probes allow their detection by MR imaging.
11C-MCG: Synthesis, Uptake Selectivity, and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase)
Authors: Pomper Martin G. , Musachio John L. , Zhang Jiazhong , Scheffel Ursula , Zhou Yun , Hilton John , Maini Atul , Dannals Robert F. , Wong Dean F. , Kozikowski Alan P.
Published: March 2018

Imaging of glutamate carboxypeptidase II (GCP II), also known as N-acetylated α-linked l-amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET). Radiosynthesis of 11C–MeCys–C(O)–Glu or 11C-( S)-2-[3-(( R)-1-carboxy-2-methylsulfanyl-ethyl)-ureido]-pentanedioic acid (11C-MCG), an asymmetric urea and potent ( Ki = 1.9 nM) inhibitor of GCP II, was performed by C-11 methylation of the free thiol. Biodistribution of 11C-MCG was assayed in mice, and quantitative PET was performed in a baboon. 11C-MCG was obtained in 16% radiochemical yield at the end of synthesis with specific radioactivities over 167 GBq/mmol (4000 Ci/mmol) within 30 min after the end of bombardment. At 30 min postinjection, 11C-MCG showed 33.0 ± 5.1%, 0.4 ± 0.1%, and 1.1 ± 0.2% ID/g in mouse kidney (target tissue), muscle, and blood, respectively. Little radioactivity gained access to the brain. Blockade with unlabeled MCG or 2-(phosphonomethyl)pentanedioic acid (PMPA), another potent inhibitor of GCP II, provided sevenfold and threefold reductions, respectively, in binding to target tissue. For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery.
Kinetic Analysis of 2-[11C]Thymidine PET Imaging Studies of Malignant Brain Tumors: Compartmental Model Investigation and Mathematical Analysis
Authors: Wells Joanne M. , Mankoff David A. , Muzi Mark , O'Sullivan Finbarr , Eary Janet F. , Spence Alexander M. , Krohn Kenneth A.
Published: March 2018

2-[11C]Thymidine (TdR), a PET tracer for cellular proliferation, may be advantageous for monitoring brain tumor progression and response to therapy. We previously described and validated a five-compartment model for thymidine incorporation into DNA in somatic tissues, but the effect of the blood–brain barrier on the transport of TdR and its metabolites necessitated further validation before it could be applied to brain tumors. Methods: We investigated the behavior of the model under conditions experienced in the normal brain and brain tumors, performed sensitivity and identifiability analysis to determine the ability of the model to estimate the model parameters, and conducted simulations to determine whether it can distinguish between thymidine transport and retention. Results: Sensitivity and identifiability analysis suggested that the non-CO2 metabolite parameters could be fixed without significantly affecting thymidine parameter estimation. Simulations showed that K1t and KTdR could be estimated accurately ( r = .97 and .98 for estimated vs. true parameters) with standard errors < 15%. The model was able to separate increased transport from increased retention associated with tumor proliferation. Conclusion: Our model adequately describes normal brain and brain tumor kinetics for thymidine and its metabolites, and it can provide an estimate of the rate of cellular proliferation in brain tumors.