bluuebunny/crossref_metadata_2025 huggingface dataset:
Consensus in Action: Context-Specific Physical Activity Guidelines for Undergraduate Students at a South African University
Authors: Johannes Chanté , Roman Nicolette V. , Onagbiye Sunday O. , Titus Simone , Leach Lloyd L.
Published: December 2024

Physical inactivity among undergraduate university students has been considered a public health concern. To address this, researchers have utilized consensus workshop approaches to develop effective physical activity (PA) recommendations. However, the existing research has limitations: it is outdated, not context-specific to young adults, and does not account for psychosocial factors (such as mental health, motivation, and social support) that hinder or promote PA behavior, particularly in South Africa. Therefore, the purpose of this study was to engage with stakeholders to achieve a consensus on a set of context-specific guidelines to enhance the physical activities of undergraduate university students. Utilizing the Social Ecological Model, this study employed two online consensus workshops with 25 purposively selected stakeholders (Round 1 = 8 and Round 2 = 17). Stakeholders were divided into breakout rooms via the Google Meets feature, to discuss and brainstorm the guidelines, expressing their agreement or disagreement with the proposed names and descriptions. The consensus was considered achieved when the majority of stakeholder responses fell into the ‘Agree with the guideline’ category. An inductive thematic analysis approach was used to generate common themes, which were then coded via Atlas Ti. V8. Stakeholders reached a consensus on four categories and 32 guidelines, namely, PA (9 guidelines), mental health (7 guidelines), motivation (9 guidelines), and social support (7 guidelines). Each category, along with its respective set of guidelines, provides insights into the type of information undergraduate students require to enhance their PA participation. Using a consensus workshop facilitated the co-creation of context-specific guidelines to enhance the physical activities of undergraduate university students. This approach proved to be a valuable tool for fostering collaboration between academic staff and students.
Characterising a Novel Therapeutic Target for Psoriasis, TYK2, Using Functional Genomics
Authors: Rane Shraddha S. , Elyoussfi Sarah , Shellard Elan , Eyre Steve , Warren Richard B.
Published: December 2024

Psoriasis (Ps) is a debilitating immune-mediated chronic skin condition. It affects about 1–3% of the world population, with an 8–11% prevalence in Northern European populations. Tyrosine kinase 2 (TYK2) is a newly identified target for Ps. An independent non-coding genetic association with Ps has been identified ~400 kb upstream of TYK2. The variants making up the credible Ps Single-Nucleotide Polymorphism (SNP) set were identified in their genomic context with the potential to influence TYK2 expression by interacting with regulatory elements involved in gene regulation. Previous evidence from our laboratory has suggested that credible SNP sets in intronic regions can be distal regulators of the genes of interest through long-range chromatin interactions. We hypothesise that SNPs at ILF3 are distal regulators of TYK2 expression via long-range chromatin interactions and Ps risk. The dysregulation of the TYK2 pathway in Ps may be mediated by a combination of GWAS risk SNPs at ILF3 and TYK2 and downstream genes. We investigated this by employing functional genomics and molecular biology methods. We developed a CD4 T cell model system with Jurkat-dCAS9-VP64 and Jurkat-dCAS9-KRAB cells using CRISPR activation and CRISPR inhibition of the risk variants rs892086 and rs7248205, selected from the latest Ps GWAS SNP set for their long-range interaction and light Linkage Disequilibrium (R2 > 0.8), respectively. Using CRISPR activation, we demonstrate here that these risk SNPs, although distal to TYK2, do indeed regulate the TYK2 gene. Investigations into annotating the TYK2 pathway using RNA-seq analysis revealed differentially regulated genes, including VEGFA, C1R, ADORA1, GLUD2, NDUFB8, and FCGR2C, which are thought to be implicated in Ps. These genes were observed to be associated with conditions such as psoriatic arthritis, atopic dermatitis, and systemic sclerosis when compared using published databases, which confirms their relevance and importance in inflammatory conditions. With the developed cell model systems using CRISPR technology and differential gene regulation, we demonstrate here that these genes have the potential to define the TYK2/Ps pathway and our understanding of the disease biology.
An Approach to Identifying Single-Nucleotide Mutations Using Noncovalent Associates of Gold Nanoparticles with Fluorescently Labeled Oligonucleotides
Authors: Epanchintseva Anna V. , Gorbunova Ekaterina A. , Nekrasov Mikhail D. , Poletaeva Julia E. , Pyshnaya Inna A.
Published: December 2024

Globally, widespread tuberculosis is one of the acute problems of healthcare. Drug-resistant forms of tuberculosis require a personalized approach to treatment. Currently, rapid methods for detecting drug resistance of Mycobacterium tuberculosis (MTB) to some antituberculosis drugs are often used and involve optical, electrochemical, or PCR-based assays. Despite the large number of these assays, it is necessary to develop new tests (for drug-resistant MTB strains) that are structurally simple and do not require specialized equipment. Colorimetric assays involving a colloidal solution of gold nanoparticles (AuNPs) have good potential for the development of the needed diagnostic tools. Here, conditions were found for the formation of tandem duplexes between DNA probes and DNA targets, representing a part of MTB gene gyrA, either wildtype or containing a single-nucleotide polymorphism associated with fluoroquinolone resistance of MTB. Adsorption of the duplexes on AuNPs allowed to distinguish the two targets owing to the formation of nano-constructs of different structures. Interaction of DNA with AuNPs was analyzed by optical spectroscopy, dynamic light scattering, and transmission electron microscopy. A scheme is proposed for direct colorimetric detection of the fluoroquinolone-resistance-associated single-nucleotide polymorphism at a 2 nM concentration in a liquid system based on a shift of AuNPs’ optical absorption maximum.
Structural Elucidation and In Silico-Aided Toxicity Prediction of Forced Degradation Products of Ginsenoside Re Using Ultra-High-Performance Liquid Chromatography Equipped with a Diode Array Detector and Charged Aerosol Detector (UHPLC-DAD-CAD) and Liquid Chromatography Coupled to a High-Resolution Mass Detector (LC-HRMS)
Authors: Guo Yaqing , Wu Kai , Yang Haoran , Lin Xiaoyu , Yang Huiying , Wu Xianfu
Published: December 2024

Ginsenoside Re was the major bioactive component found rich in Panax ginseng C. A. Meyer, which exerted excellent cardiovascular protection, anti-inflammatory, and anti-oxidation effects. The generation of unexpected degradation products (DPs) may influence the therapeutic effect of Re, or even bring toxic effects to patients. However, to date, only a few reports were available about the stability of Re. The present study aims to systematically investigate the degradation behaviors of Re under different stress conditions, including hydrolysis (acidic, basic, and neutral), oxidation, humidity, thermal, and photolytic (ultraviolet and visible light) conditions. A total of thirteen DPs were putatively identified, and among them, nine were discovered for the first time in our study. The results showed that Re was sensitive to exposure to acidic, basic, and oxidation conditions. It underwent a series of chemical degradation reactions, including deglycosylation, dehydration, addition, oxidation at the double bond, and isomerization under various stress conditions. Structural characterization of these DPs was carried out by UHPLC-DAD-CAD and LC-LTQ/Orbitrap. A plausible mechanism of their formation was proposed to support the structures of all DPs of Re. In silico toxicity prediction and metabolism behavior assessment were done by Derek Nexus and Meteor Nexus software. Re and DP-1 to DP-6 were predicted to possess potential skin irritation/corrosion toxicity. DP-11 and DP-12 bear the potential for carcinogenicity, mutagenicity, irritation, hepatotoxicity, and skin sensitization. The observation of these DPs updates our knowledge regarding the stability of Re, which provides valuable information for quality control and to choose suitable storage conditions.
Salicylic Acid Mediates Chitosan-Induced Immune Responses and Growth Enhancement in Barley
Authors: Poznanski Pawel , Shalmani Abdullah , Bryla Marcin , Orczyk Waclaw
Published: December 2024

Chitosan (CS), derived from the partial deacetylation and hydrolysis of chitin, varies in the degree of deacetylation, molecular weight, and origin, influencing its biological effects, including antifungal properties. In plants, CS triggers immune responses and stimulates biomass growth. Previously, we found that the antifungal activity of CS was strongly dependent on its physicochemical properties. This study revealed that the chitosan batch CS_10 with the strongest antifungal activity also effectively activated plant immune responses and promoted biomass growth. Barley treated with CS_10 exhibited systemic acquired resistance (SAR), characterized by micronecrotic reactions upon Puccinia hordei (Ph) inoculation and reduced symptoms following Fusarium graminearum (Fg) infection, representing biotrophic and necrotrophic pathogens, respectively. CS_10 treatment (concentration 200 ppm) also enhanced plant biomass growth (by 11% to 15%) and promoted the accumulation of salicylic acid (SA), a hormone that regulates both plant immune responses and growth. Low levels of exogenous SA applied to plants mirrored the stimulation observed with CS_10 treatment, suggesting SA as a key regulator of CS_10-induced responses. Transcriptomic analysis identified SA-regulated genes as drivers of enhanced immunity and biomass stimulation. Thus, CS_10 not only fortifies plant defenses against pathogens like Ph and Fg but also boosts growth through SA-dependent pathways.
Alterations in the Microbiomes and Metabolic Profiles of the Ileal Between the Hu Sheep and East Friesian Sheep
Authors: Yao Wenna , Zhao Yue , Yan Shuo , Zhang Huimin , Bao Teligun , Bao Siqin , Li Xihe , Song Yongli
Published: December 2024

The East Friesian sheep is a dairy breed known for its high fertility and high milk production and is currently one of the best dairy sheep breeds in the world. This breed is known to have a poor disease-resistant phenotype compared to Hu sheep. Gut microbiota and metabolites play a role in host disease resistance. The intestinal bacterial microbiota is essential for maintaining the health of sheep and ensuring their productive potential, and it may also help explain disease-resistant phenotypic differences related to breeds. However, the ileum microbiota and metabolite profiles of Hu sheep and East Friesian sheep have remained poorly characterized. The ileal is a significant organ in the intestinal tract, and most nutrients and minerals in food are absorbed through the small intestine. It is necessary to understand the composition of both species’ ileal microbiota and metabolites using the same feeding conditions. Therefore, studying the differences in the ileal microorganisms between breeds is essential to decipher the mechanisms behind these differences and identify microorganisms that influence the disease-resistant phenotype drive of ruminants. Due to the poor disease-resistant phenotype in sheep during the weaning period, with diarrhea and other diseases most likely to occur, we selected dairy sheep that were just two months old and had recently been weaned. This study comprehensively examined differences between the ileal microbiota in a large cohort of two breeds of sheep, including six Hu sheep and six East Friesian sheep. Using 16S rRNA and non-targeted metabolomics analysis, we determined that the Hu sheep had more microorganisms, including Lactobacillus, Bifidobacterium, Streptococcus, and Limmosilactobacillus, and more metabolites, including 2,7-Dihydroxy-5-methyl-1-naphthoic acid, Leu-Pro-Glu-Phe-Tyr, dodecanoic acid, Ala-Gln-Phe-Ile-Met, and Ala-Gln-Glu-Val-His, compared to the EF sheep group. Moreover, the Hu sheep were significantly enriched in amino acid biosynthesis, fatty acid metabolites, and bile secretion compared to the EF sheep groups, which may have been the main driver of the observed differences in disease-resistant phenotypes between the Hu sheep and East Friesian sheep. In addition, we hypothesized that there may be multiple beneficial microbes and metabolites that modulate the immune response and ultimately affect disease resistance. Therefore, these findings provide insights into the mechanisms underlying disease-resistant phenotype in sheep and may provide useful information for optimizing the composition of the ileal bacterial microbiota in sheep.
Computational Analysis of Self-Healing in Nanomaterials Using Neural Spike Algorithms
Authors: Seol Jongho , Kim Jongyeop , Kancharla Abhilash
Published: December 2024

This computational study investigates dynamic self-healing processes in nanomaterials driven by neuronal spike activity. We developed a multiscale simulation framework that integrates neuronal dynamics, quantum mechanical effects, and material science principles. Our model incorporates a time-dependent neuron spike voltage equation coupled with a nanomaterial health update function, including quantum probability terms, to capture nanoscale effects. We employ reliability engineering concepts to assess system performance. Simulations reveal that neuronal spike patterns significantly influence self-healing dynamics, exhibiting non-linear behavior with quantum effects crucial to healing efficiency. Statistical analysis demonstrates a strong correlation between spike frequency and healing rate, identifying an optimal range for maximum recovery. Integrating quantum probabilities yields more accurate nanoscale behavior predictions than classical approaches alone. This study provides a foundation for understanding and optimizing neuronal spike-induced recovery in nanomaterials with potential applications in neural interfaces, intelligent materials, and biomedical devices.
Research on the Application of Topic Models Based on Geological Disaster Information Mining
Authors: Cheng Gang , You Qinliang , Li Gangqiang , Li Youcai , Yang Daisong , Wu Jinghong , Wu Yaxi
Published: December 2024

Geological disasters, as a common occurrence, have a serious impact on social development in terms of their frequency of occurrence, disaster effects, and resulting losses. To effectively reduce the casualties, property losses, and social effects caused by various disasters, it is necessary to conduct real-time monitoring and early warning of various geological disaster risks. With the growing development of the information age, public attention to disaster relief, casualties, social impact effects, and other related situations has been increasing. Since social media platforms such as Weibo and Twitter contain a vast amount of real-time data related to disaster information before and after a disaster occurs, scientifically and effectively utilizing these data can provide sufficient and reliable information support for disaster relief, post-disaster recovery, and public appeasement efforts. As one of the techniques in natural language processing, the topic model can achieve precise mining and intelligent analysis of valuable information from massive amounts of data on social media to achieve rapid use of thematic models for disaster analysis after a disaster occurs, providing reference for post-disaster-rescue-related work. Therefore, this article first provides an overview of the development process of the topic model. Secondly, based on the technology utilized, the topic models were roughly classified into three categories: traditional topic models, word embedding-based topic models, and neural network-based topic models. Finally, taking the disaster data of “Dongting Lake breach” in Hunan, China as the research object, the application process and effectiveness of the topic model in urban geological disaster information mining were systematically introduced. The research results provide important references for the further practical innovation and expansion of the topic model in the field of disaster information mining.
Guidelines for Nonlinear Finite Element Analysis of Reinforced Concrete Columns with Various Types of Degradation Subjected to Seismic Loading
Authors: Khedmatgozar Dolati Seyed Sasan , Matamoros Adolfo , Ghannoum Wassim
Published: December 2024

Concrete columns are considered critical elements with respect to the stability of buildings during earthquakes. To improve the accuracy of column damage and collapse risk estimates using numerical simulations, it is important to develop a methodology to quantify the effect of displacement history on column force–deformation modeling parameters. Addressing this knowledge gap systematically and comprehensively through experimentation is difficult due to the prohibitive cost. The primary objective of this study was to develop guidelines to simulate the lateral cyclic behavior and axial collapse of concrete columns with different modes of failure using continuum finite element (FE) models, such that wider parametric studies can be conducted numerically to improve the accuracy of assessment methodologies for critical columns. This study expands on existing FEM research by addressing the complex behavior of columns that experience multiple failure modes, including axial collapse following flexure–shear, shear, and flexure degradation, a topic which has been underexplored in previous works. Nonlinear FE models were constructed and calibrated to experimental tests for 21 columns that sustained flexure, flexure–shear, and shear failures, followed by axial failure, when subjected to cyclic and monotonic lateral displacement protocols. The selected columns represented a range of axial loads, shear stresses, transverse reinforcement ratios, longitudinal reinforcement ratios, and shear span-to-depth ratios. Recommendations on optimal material model parameters obtained from a parametric study are presented. Metrics used for optimization include crack widths, damage in concrete and reinforcement, drift at initiation of axial and lateral strength degradation, and peak lateral strength. The capacities of shear–critical columns calculated with the optimized numerical models are compared with experimental results and standard equations from ASCE 41-17 and ACI 318-19. The optimized finite element models were found to reliably predict peak strength and deformation at the onset of both lateral and axial strength failure, independent of the mode of lateral strength degradation. Also, current standard shear capacity provisions were found to be conservative in most cases, while the FE models estimated shear strength with greater accuracy.
Controversial Roles of Autophagy in Adenomyosis and Its Implications for Fertility Outcomes—A Systematic Review
Authors: Vervier Julie , Squatrito Marlyne , Nisolle Michelle , Henry Laurie , Munaut Carine
Published: December 2024

Background/Objectives: Adenomyosis is a benign condition where ectopic endometrial glandular tissue is found within the uterine myometrium. Its impact on women’s reproductive outcomes is substantial, primarily due to defective decidualization, impaired endometrial receptivity, and implantation failure. The exact pathogenesis of the disease remains unclear, and the role of autophagy in adenomyosis and its associated infertility is not well understood. The aim of this systematic review was to conduct an exhaustive search of the literature to clarify the role of autophagy in the pathogenesis of adenomyosis. Methods: A systematic search was conducted in Medline, Embase, and Scopus databases up to the date of 20 August 2024. We included all English-written publications assessing the role of autophagy in the pathogenesis of adenomyosis. Results: Seventeen eligible articles were identified, including reviews and experimental studies involving human samples and murine models. The results showed that the role of autophagy in adenomyosis is controversial, with studies showing both increased and decreased levels of autophagy in adenomyosis. Conclusions: Autophagy plays a dual role in cell survival and death. Increased autophagy might support the survival and proliferation of ectopic endometrial cells, while decreased autophagy could prevent cell death, leading to abnormal growth. Oxidative stress may trigger pro-survival autophagy, mitigating apoptosis and promoting cellular homeostasis. Hormonal imbalances disrupt normal autophagic activity, potentially impairing endometrial receptivity and decidualization and contributing to infertility. The balance of autophagy is crucial in adenomyosis, with its dual role contributing to the complexity of the disease. Limitations: A few studies have been conducted with heterogeneous populations, limiting comparative analyses.
Prescriptive Appropriateness and Efficacy of Cholesterol-Lowering Drugs in a Secondary Prevention Setting—A Retrospective Analysis from Two Italian Cardiac Rehabilitation Centers
Authors: Saladini Francesca , Baggio Stefania , Marcato Federica , Campisi Francesco , Verlato Roberto , Pasquetto Giampaolo , Bertaglia Emanuele , Povolo Gaetano , Buja Paolo , Ferri Nicola
Published: December 2024

Background: Treatment of CV risk factors, such as cholesterol level, represents one of the main goals to reduce atherosclerotic burden. The aim of this study was to investigate the prescriptive appropriateness of cholesterol-lowering drugs among patients who experienced an atherosclerotic CV disease (ASCVD). Methods: We investigated 155 patients who underwent cardiac rehabilitation in 2020. The European Society of Cardiology (ESC) 2021 guidelines on CV disease prevention and 2019 ESC Guidelines on dyslipidemias were followed to detect the appropriateness of prescription. SCORE2 and SCORE2-OP risk estimations were used to detect patients’ CV risk profiles. Patients were divided into three groups: 1 (n = 118) patients admitted for their first CV event, 2A (n = 18) patients who experienced a previous CV event years before, and 2B (n = 19) patients admitted for a new event with a previous CV event 2 years before. Low-density lipoprotein (LDL) cholesterol level was detected at the time of admission to the hospital, during cardiac rehabilitation, and at the first visit after rehabilitation. Results: The statistics for our study participants, with a mean age of 66.1 years, were: 72.4% overweight/obese, 63.9% diabetic, 72.5% smokers, 93.0% hypertensives, and 91.7% had dyslipidemias. In group 1, only 5.1% had a low/moderate risk, 44.1% presented a high risk, and 50.8% a very high risk according to calculators. The average LDL levels were 115.8 mg/dL (2.99 mol/L) upon admission to the hospital, 66.4 mg/dL (1.72 mmol/L) at the time of cardiac rehabilitation, and 64.8 mg/dL (1.67 mmol/L) at the subsequent medical visit. In the overall group, only 36.0% had LDL < 55 mg/dL (1.42 mmol/L). In group 1, 79.4% were treated with high-intensity statin alone or plus ezetimibe; in group 2A, the percentage increased up to 87.5%, while group 2B 33.4% was treated with high-intensity statin plus ezetimibe and 33.3% were treated with PCSK9 inhibitors. Conclusions: This retrospective study confirms the importance of properly calculating CV risk profiles. The main limitations for the efficacy of lipid-lowering drugs were: patient’s compliance, drugs side effects, lifestyle habits, and collaboration with a general practitioner.
Single-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope’s Clinical Trial Teams
Authors: Cosgrove Patrick A. , Bild Andrea H. , Dellinger Thanh H. , Badie Behnam , Portnow Jana , Nath Aritro
Published: December 2024

Tumor heterogeneity is a significant factor influencing cancer treatment effectiveness and can arise from genetic, epigenetic, and phenotypic variations among cancer cells. Understanding how tumor heterogeneity impacts tumor evolution and therapy response can lead to more effective treatments and improved patient outcomes. Traditional bulk genomic approaches fail to provide insights into cellular-level events, whereas single-cell RNA sequencing (scRNA-seq) offers transcriptomic analysis at the individual cell level, advancing our understanding of tumor growth, progression, and drug response. However, implementing single-cell approaches in clinical trials involves challenges, such as obtaining high-quality cells, technical variability, and the need for complex computational analysis. Effective implementation of single-cell genomics in clinical trials requires a collaborative “Team Medicine” approach, leveraging shared resources, expertise, and workflows. Here, we describe key technical considerations in implementing the collection of research biopsies and lessons learned from integrating scRNA-seq into City of Hope’s clinical trial design, highlighting collaborative efforts between computational and clinical teams across breast, brain, and ovarian cancer studies to understand the composition, phenotypic state, and underlying resistance mechanisms within the tumor microenvironment.
Correction of Femoral Torsional Deformities by Rotational Guided Growth
Authors: Zaidman Michael , Simanovsky Naum , Goldman Vladimir , Weisstub Eden
Published: December 2024

Background: Femoral torsional malalignment is a common cause of in-toeing and out-toeing in children, often leading to gait disturbances, functional limitations, and increased risk of falls. Traditionally, osteotomy was the only surgical option for correction. A minimally invasive technique known as rotational guided growth (RGG) has recently been introduced to address these malalignments. This study aims to assess the effectiveness of rotational femoral malalignment correction by rotational epiphysiodesis with tension band 8-plates (Orthofix, Verona, Italy). Methods: Eleven patients with in-toeing and out-toeing (19 femurs) were treated using RGG with 8-plates. The 8-plates were applied laterally and medially, with screws placed above and below the growth plate of the distal femur, angled obliquely to the long axis of the bone in opposite directions. Changes in foot progression angle (FPA), femoral version, the alteration in the angle between the 8-plates, and the rate of correction were recorded. Results: All patients reported functional gait improvement. The FPA was corrected from a mean of 32 degrees to 7 degrees, the femoral version improved from a mean of 60 degrees to 22 degrees. The angle between the 8-plates changed from a mean of 75 degrees to 28 degrees, with a correction rate of 4.1 degrees per month. The average time for correction was 11 months. No complications were observed during the treatment. Conclusions: RGG using 8-plates is a novel, minimally invasive surgical technique that effectively corrects rotational femoral deformities and may serve as a preferred alternative to derotational osteotomy in growing patients.
Adhesion Prevention in Gynecologic Surgery: Guidance and Clinical Experience
Authors: Alkatout Ibrahim , De Wilde Rudy Leon , Herrmann Jörg , Klapdor Rüdiger , Meinhold-Heerlein Ivo , Mészáros József , Mustea Alexander , Oppelt Peter , Pape Julian Maria , Schäfer Sebastian Daniel , Wallwiener Markus , Krämer Bernhard
Published: December 2024

Postoperative adhesions represent a major medical challenge and are associated with serious health and economic consequences. 4DryField® PH (PlantTec Medical GmbH, Lueneburg, Germany) is a starch-based medical device designed both to prevent adhesions and for hemostasis. This paper explores methods to successfully apply it in gynecological surgery, leveraging the authors’ extensive clinical experience. We provide detailed insights into best practices that benefit most patients with conditions such as endometriosis, along with practical tips and guidance on optimizing application and dosage. Our real-world clinical experience across various indications, supported by published data, demonstrates significant patient benefits: reduced adhesion formation, better recovery, less pain, and improved fertility. Patient acceptance and satisfaction are notably high. The device can be applied to surgical wounds as a powder for hemostasis and transformed into a gel in situ or as a premixed gel when adhesion prevention is prioritized. Specific advantages for each method are demonstrated by case studies. When used correctly, 4DryField PH is safe and effective, especially for larger wound areas with a high risk of reoperation and adhesion formation and when pregnancy is desired. It offers great versatility due to its use as either in situ gel or premixed gel with different viscosities. Despite some remaining gaps in clinical evidence and ongoing studies, our personal clinical experience suggests significant benefits with minimal risks. Therefore, we have no concerns regarding the broad use of 4DryField PH in gynecology and other surgical disciplines. Future research should focus on patient-reported outcomes and health economic benefits to support reimbursement efforts.
Correction: Braidotti et al. A Consolidated Linearised Progressive Flooding Simulation Method for Onboard Decision Support. J. Mar. Sci. Eng. 2024, 12, 1367
Authors: Braidotti Luca , Prpić-Oršić Jasna , Bertagna Serena , Bucci Vittorio
Published: December 2024

In the original publication [...]
Numerical Study on the Wave Attenuation Performance of a Novel Partial T Special-Type Floating Breakwater
Authors: Ruan Xuanqi , Qian Hongliang , Dai Jingxuan , Fan Feng , Niu Shuang
Published: December 2024

Floating breakwaters (FBs) play an important role in protecting coastlines, marine structures, and ports due to their simple construction, convenient movement, cost-effectiveness, and environmental friendliness. However, the traditional box-type FBs are flawed due to their requiring large sizes for wave attenuation and their overly high level of wave reflection. In this paper, a novel partial T special-type FB with wave attenuation on the surface and flow blocking below the water has been presented. First, the User-Defined Function (UDF) feature in ANSYS Fluent was employed to compile the six degrees of freedom (6-DOF) motion model. A two-dimensional viscous numerical wave flume was developed using the velocity boundary wave-generation method and damping dissipation wave-absorption method, with fully coupled models of the FBs developed. A VOF multiphase flow model and a RANS turbulence model were employed to capture the free flow of gas–liquid two-phase flow. Then, the performance of wave attenuation of the new FB was compared with that of the traditional box-type FB of the same specifications. The simulation results showed that the transmission coefficient of the new FB is significantly lower than that of the box-type FB, and the dissipation coefficient is notably higher, demonstrating excellent performance of wave attenuation, particularly for long-period waves. As wave height increases, the novel FB benefits from its wave attenuation mechanism, with a lower reflection coefficient compared to the box-type FB. Finally, through parametric analysis, some design recommendations of the novel FB suitable for practical engineering applications in deep-sea aquaculture are presented.
Aflatoxin B1 Contamination Association with the Seed Coat Biochemical Marker Polyphenol in Peanuts Under Intermittent Drought
Authors: Aminou Maman Moutari , Falalou Hamidou , Abdou Harou , Mendu Venugopal
Published: December 2024

Aflatoxin B1 (AFB1) contamination (AC) increases as the severity of drought stress increases in peanuts. Identifying drought-tolerant (DT) genotypes with resistance to Aspergillus flavus colonization and/or infection may aid in developing peanuts resistant to aflatoxin contamination in the semi-arid tropics. The goal of this study is to identify DT genotypes with seed coat biochemical resistance to A. flavus infestation and aflatoxin contamination. Experiments were carried out at ICRISAT Sahelian Center; fifty-five genotypes were assessed under adjacent intermittent water-stressed (WS) conditions imposed from the 60th day after sowing to the maturity date and well-watered (WW) conditions in an alpha lattice design with two factors. The yield and its components, the incidence of A. flavus colonization, aflatoxin contamination, and seed coat total polyphenol (SCTPP) were investigated. Our findings show that the water deficit reduced the pod yield, seed yield, and haulm yield by up to 19.49%, 27.24%, and 22.07%, respectively, while it increased the number of immature pods per plant (IMPN) and the aflatoxin contamination by up to 67.16% and 54.95%, respectively. The drought tolerant genotypes ICG 2106, ICG 311, ICG 4684, ICG 4543, and ICG 1415 maintained a high yield, small number of IMPN under WS and low aflatoxin content variation between WW and WS. Our findings revealed that in the drought-tolerant genotypes ICG 1415, ICG 2106, ICG 311, ICG 4684, and ICG 4543, there was a significant relationship between the aflatoxin resistance and the seed coat total polyphenol under the two water treatments (r2 = 0.80; r2 = 0.82). This suggests that these drought-tolerant genotypes kept their seed coat intact and minimized the aflatoxin contamination under an intermittent water deficit.
Evaluating Telehealth Diagnostic Accuracy in Oral and Maxillofacial Diseases: A Comparative Study
Authors: Lau Jeremy , Frydrych Agnieszka M. , Parsons Richard , Balasubramaniam Ramesh , Kujan Omar
Published: December 2024

Objectives: This study evaluated the accuracy of diagnosing oral and maxillofacial diseases using telehealth. Methods: We recruited 100 patients from the Oral Health Centre of Western Australia. They were either new patients or existing patients with a condition not previously diagnosed. The patients initially underwent a telehealth consultation without administrative or clinical staff assistance. On the same day, they also received a traditional in-office (face-to-face) consultation with an Oral Medicine registrar and/or consultant. Results: In this study, 70 patients were consulted via telehealth for a mucosal condition, while 30 were consulted for orofacial pain. When comparing telehealth diagnoses to in-person diagnoses, 65.7% of mucosal cases and 70% of orofacial pain cases had the same diagnosis. Furthermore, regarding the diagnoses within the chief complaint’s telehealth differential diagnosis list, 87.1% were similar in the mucosal cases, and 96.7% were similar in orofacial pain cases compared to the in-office consultation. Conclusions: Our study’s findings demonstrate that telehealth is less reliable than the gold standard in-person consultation for diagnosing oral diseases. However, it shows promise as an adjunctive service for screening, triaging, and monitoring patients. Further studies with guidelines for patients undergoing telehealth consultations to improve the diagnostic accuracy of oral and maxillofacial diseases are necessary.
Cerebral Amyloid-β Deposition, Axial Features, and Cognitive Alterations in Patients with Parkinson’s Disease Treated with Bilateral STN-DBS: A Long-Term Cohort Study
Authors: Cavallieri Francesco , Fraternali Alessandro , Arnone Annachiara , Campanini Isabella , Marti Alessandro , Gessani Annalisa , Fioravanti Valentina , Molinari Maria Angela , Di Rauso Giulia , Antonelli Francesca , Rispoli Vittorio , Feletti Alberto , Stanzani Riccardo , Damiano Benedetta , Scaltriti Sara , Cavazzuti Lorenzo , Bardi Elisa , Corni Maria Giulia , Cavalleri Francesca , Biagini Giuseppe , Pavesi Giacomo , Lusuardi Mirco , Budriesi Carla , Merlo Andrea , Versari Annibale , Valzania Franco
Published: December 2024

Objectives: Our aim was to evaluate the possible long-term cerebral deposition of amyloid-β in patients with PD treated with subthalamic nucleus deep brain stimulation (STN-DBS) and its possible influence on axial and cognitive variables. Methods: Consecutive PD patients treated with bilateral STN-DBS with a long-term follow-up were included. The amyloid-β deposition was evaluated postoperatively through an 18F-flutemetamol positron emission tomography (PET) study. Axial symptoms were assessed using a standardized clinical–instrumental approach. The speech was assessed by perceptual and acoustic analysis, while gait was assessed by means of the instrumented Timed Up and Go test (iTUG). Motor severity was evaluated by applying the UPDRS part III score and subscores, while cognitive functions were assessed through a complete neuropsychological assessment. Different stimulation and drug conditions were assessed: on-stimulation/off-medication, off-stimulation/off-medication, and on-stimulation/on-medication conditions (single- and dual-task). Results: In total, 19 PD patients (male: 11; age: 63.52 years; on-stimulation/on-medication UPDRS-III: 17.05) with a five-year postoperative follow-up were included. The amyloid-β deposition was found in 21% of patients (4/19) with a prevalent involvement of prefrontal, limbic, and parietal areas. Compared with patients without amyloid-β deposition, PD patients with positive 18F-flutemetamol in the PET study showed a higher preoperative UPDRS-I (p = 0.037) score. Conclusions: Our results suggest that in the long term, after STN-DBS, a significant percentage of PD patients may present brain amyloid-β deposition. However, larger samples are needed to evaluate the possible role of amyloid-β deposition in the development of axial and cognitive alterations after surgery.
Bachelier’s Market Model for ESG Asset Pricing
Authors: Rachev Svetlozar , Asare Nyarko Nancy , Omotade Blessing , Yegon Peter
Published: December 2024

Environmental, Social, and Governance (ESG) finance is a cornerstone of modern finance and investment, as it changes the classical return-risk view of investment by incorporating an additional dimension to investment performance: the ESG score of the investment. We define the ESG price process and include it in an extension of Bachelier’s market model in both discrete and continuous time, enabling option pricing valuation.
Determining Driving Risk Factors from Near-Miss Events in Telematics Data Using Histogram-Based Gradient Boosting Regressors
Authors: Sun Shuai , Guillen Montserrat , Pérez-Marín Ana M. , Ni Linglin
Published: December 2024

This study introduces a novel method for driving risk assessment based on the analysis of near-miss events captured in telematics data. Near-miss events, which are highly correlated with accidents, are employed as proxies for accident prediction. This research employs histogram-based gradient boosting regressors (HGBRs) for the analysis of telematics data, with comparisons made across datasets from China and Spain. The results presented in this paper demonstrate that HGBR outperforms conventional generalized linear models, such as Poisson regression and negative binomial regression, in predicting driving risks. Furthermore, the findings suggest that near-miss events could serve as a substitute for traditional claims in calculating insurance premiums. It can be seen that the machine learning algorithm offers the prospect of more accurate risk assessments and insurance pricing.
Diet Supplementation with Ketoanalogues, Inulin, and Calcium Citrate in Chronic Kidney Disease: A Retrospective Cohort
Authors: Calderón-Juárez Martín , Saavedra-Fuentes Nadia , Del Castillo-Loreto Karla Guadalupe , Castillo-Salinas Juan Carlos , Lerma Claudia
Published: December 2024

The addition of ketoanalogues (KAs) to a low-protein diet has been shown to mitigate the progression of pre-dialysis chronic kidney disease (CKD). The addition of inulin and calcium citrate may add further benefits, given their nephroprotective effects. In this study, we tested the changes in estimated glomerular filtration rate (eGFR), CKD symptoms, body composition, and biochemical parameters after 6 months of diet supplementation with Cetolán III, a combination of KA, inulin, and calcium citrate. We included 76 adult patients diagnosed with CKD stages 3 and 4 and not treated with renal replacement therapy in a retrospective cohort. In this cohort, participants were followed through two clinic visits at 3 and 6 months after diet supplementation. We found a slight increase in eGFR at 3 and 6 months compared with baseline, as well as a decrease in the severity of CDK-related symptoms, fat mass, and muscle mass. We observed only a slight decrease in creatinine and uric acid after 6 months of follow-up. We did not find a remarkable change in anthropometric parameters (e.g., body mass index, waist circumference, and arm muscle area). This observational study suggests that addition of KA, inulin, and calcium citrate to a low protein- diet could be associated with an improvement in eGFR and symptom severity in CKD pre-dialysis.
Granite Dust and Silica Fume as a Combined Filler of Reactive Powder Concrete
Authors: Huts Andriy , Konkol Janusz , Marchuk Vitalii
Published: December 2024

By volume, cement concrete is one of the most widely used construction materials in the world. This requires a significant amount of Portland cement, and the cement industry, in turn, causes a significant amount of CO2 emissions. Therefore, the development of concrete with a reduced cement content is becoming an urgent problem for countries with a significant level of production and consumption of concrete. Therefore, the purpose of this article is to critically investigate the possibility of using inert granite dust in combination with highly active silica fume in reactive powder concrete. The main physical and mechanical properties, such as the compressive strength at different curing ages and the water absorption, were studied using mathematical planning of experiments. The consistency and microstructure of the reactive powder concrete modified with granite dust in combination with silica fume were also analyzed. Mathematical models of the main properties of this concrete are presented and analyzed, and the graphical dependencies of the influence of composition factors are constructed. A more significant factor that affects the compressive strength at all curing ages is the silica fume content, increases in which to 50 kg/m3 lead to a 25–40% increase in strength at 1 day of age, depending on the granite dust content. In turn, an increase in the amount of granite dust from 0 kg/m3 to 100 kg/m3 in the absence of silica is followed by an increase in strength of 8–10%. After 3 days of curing, the effect of granite dust becomes more significant. Increases in the 28-day strength of 25%, 46% and 56% were obtained at a content of 50 kg/m3 of silica fume and 0 kg/m3, 100 kg/m3 and 200 kg/m3 of granite dust in concrete, respectively. It is shown that the effect of inert granite dust is more significant in combination with silica fume at its maximum content in the range of variation. The pozzolanic reaction between highly active silica and Ca(OH)2 stimulates the formation of hydrate phases in the space between the grains and causes the microstructure of the cement matrix to compact. In this case, the granite dust particles act as crystallization centers.
Effect of Sand Addition on Laterite Soil Stabilization
Authors: Almeida Bárbara Drumond , Coelho Lisley Madeira , Guimarães Antônio Carlos Rodrigues , Monteiro Sergio Neves
Published: December 2024

Lateritic soils, particularly abundant in tropical regions, have been successfully used in the construction of unbound layers of flexible pavements in Brazil since the 1970s. Despite their potential, these soils are often discarded or only recommended after stabilization processes, based on traditional parameters such as gradation requirements and Atterberg limits. This study investigates the mechanical characteristics of a lateritic soil from Roraima, focusing on its resilient modulus and permanent deformation properties, assessed through repeated load triaxial tests. Specifically, this research examines the effect of adding 20% sand on the mechanical behavior of the material. The results indicate that sand addition did not significantly improve the mechanical performance. The laterite–sand mixture exhibited an average resilient modulus (RM) of 744 MPa, lower than the 790 MPa of pure lateritic soil, suggesting that pure laterite remains suitable for pavement applications. Furthermore, the permanent deformation analysis revealed that the mixture with sand experienced nearly twice the plastic strain compared to pure laterite, which demonstrated superior accommodation under repeated loading. In the shakedown analysis, pure laterite exhibited a more stable performance, indicating greater durability in pavement applications. These findings highlight the importance of understanding the mechanical behavior of lateritic soils beyond conventional testing methods, emphasizing the potential of pure laterite as a viable alternative to enhance the strength and durability of pavement structures.
Composites Based on PLA/PHBV Blends with Nanocrystalline Cellulose NCC: Mechanical and Thermal Investigation
Authors: Bazan Patrycja , Rochman Arif , Mroczka Krzysztof , Badura Kamil , Melnychuk Mykola , Nosal Przemysław , Węglowska Aleksandra
Published: December 2024

This study investigates the physical and mechanical properties of biodegradable composites based on PLA/PHBV blends modified with different content of nanocrystalline cellulose (NCC) of 5, 10, and 15 wt.%. Density measurements reveal that the density of the composite increases with increasing NCC content. Water absorption tests demonstrate a gradual increase in the composite water content with increasing incubation time, reaching stabilization after approximately 30 days. Mechanical testing was also carried out on both on conditioned samples after the process of hydrolytic degradation and accelerated thermal aging. The conditioned composites show an increase in the stiffness of the materials with increasing content of nanocrystalline cellulose. The ability to deform and the ability to absorb energy when the sample is dynamically loaded decrease. The repeated strength tests, after the process of incubation of samples in water and after the process of accelerated thermal aging, show the degradation of composite materials; however, it is noticed that the introduction of cellulose addition reduces the impact of the applied artificial environment in aging tests. The findings of this study indicate promising applications for these types of materials, characterized by high strength and biodegradability under appropriate conditions. Household items such as various containers or reusable packaging represent potential applications of these composites.