bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Immaterial: The Premier Building Restoration Project At The Hope Waddell Institution
Authors: Laotan-Brown Tokie
Published: January 2025

The Premier Building Restoration Project at the Hope Waddell Institution sought to explore architecture as a dynamic process that transcends mere physical reconstruction, engaging deeply with the immaterial aspects that shape and define built environments. This project was set against the backdrop of the Venice Charter to address pressing environmental, spiritual and cultural concerns, yet it equally emphasizes the importance of 'weightless' elements—narratives, memories, and cultural significances—that often remain hidden beneath the surface.
Hope Waddell Institution, a historical educational complex with deep roots in Calabar, Nigeria’s socio-cultural fabric, serves as a case study for investigating the interplay between tangible and intangible heritage. The restoration project of the Premier Building is not merely about preserving the Scottish prefabricated wooden structure but about uncovering and reintegrating the institution’s rich traditional materiality,cultural heritage, stories, and historical figures that have shaped its legacy.
By utilizing an inter/multi/transdisciplinary methodology, the project incorporates archival research, community narratives, and traditional use restorative analysis to reveal the hidden layers of the Premier building’s past. This includes understanding the socio-political contexts of its establishment, the evolving educational paradigms, and the community’s ongoing relationship with the space. The project challenges traditional restoration methods, proposing a more holistic view that considers the immaterial as equally crucial to the institution’s heritage.
The Premier Building Restoration Project thus serves as a model for contemporary architectural practice, emphasizing the need to approach the built environment as a repository of hidden memories and stories. This approach not only enriches our understanding of architectural heritage but also fosters a more inclusive and reflective process of architectural (re)making, where the unseen and unheard narratives are brought to the forefront, expanding the discipline beyond its conventional boundaries.
Measurement events relative to temporal quantum reference frames
Authors: Hausmann Ladina , Schmidhuber Alexander , Castro-Ruiz Esteban
Published: January 2025

The Page-Wootters formalism is a proposal for reconciling the background-dependent, quantum-mechanical notion of time with the background independence of general relativity. However, the physical meaning of this framework remains debated. In this work, we compare two consistent approaches to the Page-Wootters formalism to clarify the operational meaning of evolution and measurements with respect to a temporal quantum reference frame. The so-called "twirled observable" approach implements measurements as operators that are invariant with respect to the Hamiltonian constraint. The "purified measurement" approach instead models measurements dynamically by modifying the constraint itself. While both approaches agree in the limit of ideal clocks, a natural generalization of the purified measurement approach to the case of non-ideal, finite-resource clocks yields a radically different picture. We discuss the physical origin of this discrepancy and argue that these approaches describe operationally distinct situations. Moreover, we show that, for non-ideal clocks, the purified measurement approach yields a time non-local evolution equation, which can lead to non-unitary evolution. Moreover, it implies a fundamental limitation to the operational definition of the temporal order of events. Nevertheless, unitarity and definite temporal order can be restored if we assume that time is discrete.
Abordagens lúdicas para a Alfabetização Midiática e Informacional (AMI)
Authors: Fonseca Hidalgo José Andrés
Published: January 2025

Este estudo explora o uso da gamificação como estratégia didática para promover a Alfabetização Midiática e Informacional (AMI) entre estudantes do ensino secundário na Costa Rica, por meio de uma oficina gamificada na plataforma “Classcraft”. Os participantes relataram um aumento na sua compreensão do conceito de AMI, bem como um alto nível de satisfação com a experiência. A motivação intrínseca foi um fator-chave para o envolvimento dos alunos, e as mecânicas de jogo utilizadas receberam feedback positivo, destacando a importância de alinhar a gamificação com os interesses dos participantes. Este estudo fornece referências para futuros projetos que busquem desenvolver processos de AMI por meio de abordagens lúdicas, promovendo assim uma educação mais dinâmica e eficaz no contexto digital atual.
From centralization to decentralization: Organizational restructuring within a legislative context in the public sector
Authors: Men Sokheang , Aimimtham Sukanya , Chamruspanth Viyouth , Nurmandi Achmad , Sohsan Imron , Lawelai Herman , Younus Muhammad
Published: January 2025

This literature review delves into the repercussions of decentralization reform on organizational frameworks worldwide. It scrutinizes the empirical correlation between past organizational setups in developing nations and current structures resulting from decentralization policies, combining various theoretical frameworks to enhance organizational architecture. The institutional reforms, short-term political motivations, instrumental incoherence, reformers’ incentives, and decentralization types (Faguet & Shami, 2022). Two principal objectives steer this research: first, to furnish a comprehensive comprehension of the historical trajectory of decentralization administration, and second, to proffer restructuring strategies for the public sector aimed at enhancing the provision of public services through decentralization strategies. This study contributes to organizational reform through decentralization initiatives, using qualitative methods and CiteSpace software. The literature review highlights the beneficial impact of administrative decentralization and innovative frameworks on system management. Furthermore, based on bibliometric analysis, the study elucidates international research collaboration among authors, organizations, and nations. Ultimately, this research sheds light on the strategic utilization of decentralization policies to restructure organizational frameworks akin to the precision of acupuncture effectively.
Ramblings on Type 1 Diabetes
Authors: Perlman Jordan
Published: January 2025

Preview
My Own Story
Authors: Hirsch Irl B.
Published: January 2025

Preview
Features of Etiological Structure of Agents of Healthcare-Associated Infections in Conditions in a Multidisciplinary Hospital of Tomsk City
Authors:   Siberian State Medical University, Perfil’yeva Dar’ya Yu. , Myroshnichenko Aleksandr G. ,   South-Ural State Medical University, Perfil’yev Vyacheslav Yu. ,   Siberian State Medical University, Boykov Vadim A. ,   Siberian State Medical University, Baranovskaya Svetlana V. ,   Siberian State Medical University, Babeshina Marina A. ,   Siberian State Medical University, Sirotina Alina S. ,   Siberian State Medical University
Published: January 2025

INTRODUCTION: Healthcare-associated infections (HAIs) currently present one of the important problems of practical healthcare. For effective planning of organizational and anti-epidemic measures, of prior importance is a continuous study of etiological agents of HAIs in the conditions of a particular medical organization.
AIM: To study the etiological structure of agents of healthcare-associated infections and determine resistance of strains to anti-microbial agents (AMAs) in a multidisciplinary hospital in Tomsk.
MATERIALS AND METHODS: A retrospective analysis of 286 medical records of inpatients with an established diagnosis of HAI was carried out in the period from 2019 to 2022. The results of bacteriological examination of biological material from patients were analyzed, and sensitivity to AMAs was studied.
RESULTS: In 38% of cases, patients had lower respiratory tract infection (LRTI), and in 16% — urinary tract infection (UTI). Surgical site infections (SSIs) in the overall structure of HAIs amounted to 34%, post-injection infections — 7% and bloodstream infections — 5%, respectively. In the etiological structure of HAIs, the key etiological role belonged to three main groups of microorganisms — representatives of the Enterobacterales, Staphylococcaceae and Pseudomonadaceae families. The study revealed resistance of Enterobacterales mainly to cefotaxime — 88%, ceftazidime — 82%, cefepime — 63%, ciprofloxacin — 75%, imipenem — 42%, meropenem — 64%, ertapenem — 46%. The leading etiological agent among the Staphylococcaceae family was Staphylococcus aureus. The proportion of methicillin-resistant strains (MRSA) was 22%. The Pseudomonadaceae family was represented by Pseudomonas aeruginosa in the etiology of HAI. The frequency of resistance of Pseudomonas aeruginosa to antibiotics was: to amikacin — 20%, cefepime — 38%, ceftazidime — 54%, ciprofloxacin — 27%, imipenem — 40%, meropenem — 33%, levofloxacin — 57%.
CONCLUSION: The main etiological agents of HAIs are members of the Enterobacterales, Staphylococcaceae and Pseudomonadaceae families. Enterobacterales and Pseudomonas aeruginosa strains were highly resistant to third and fourth generation cephalosporins, as well as to carbapenems. A relatively low level of resistance of Pseudomonas aeruginosa to ciprofloxacin was noted.
Snake Venoms: Chemical Composition and Therapeutic Potential
Authors:   N. I. Pirogov Russian National Research Medical University, Skryabina Anna A. , Saikumar Ashvin ,   N. I. Pirogov Russian National Research Medical University
Published: January 2025

INTRODUCTION: The healing properties of snake venom have been known since antiquity, making the snake a symbol of pharmacy and medicine. Snake venoms are complex mixtures con-taining proteins, peptides, enzymes and low molecular weight compounds. The study of these components has opened new perspectives in the development of drugs for the treatment of sev-eral diseases: for example, arterial hypertension and thrombosis. This review focuses on the chem-ical composition of snake venom and its potential medical uses in drug development.
The article presents a literature review of relevant scientific articles found in databases such as PubMed, Medline, Springer, eLibrary, and Google Scholar. The mixture of toxins that make up snake venom is reviewed, with emphasis on the molecular structure, chemical reactivity and target recognition of the most bioactive toxins from which bioactive drugs can be developed. The mechanism of action of drugs derived from snake venom is shown.
CONCLUSION: Studies of the major toxins found in venoms provide insight into how toxins act on their targets and how toxin action can be engineered to achieve therapeutic goals. Already approved and in development, snake venom-derived drugs demonstrate that toxic bioactivity can be converted into therapeutics. Large toxin molecules can be redesigned and reduced to their recognition motifs while maintaining affinity and specificity.
Peculiarities of the Course of Benign Prostatic Hyperplasia in Patients with Low Level of Prostate-Specific Antigen
Authors:   Voronezh Regional Clinical Hospital No. 1, Zolotukhin Oleg V. ,   N. N. Burdenko Voronezh State Medical University, Esin Aleksandr V. ,   Voronezh Regional Clinical Hospital No. 1, Madykin Yuriy Yu. ,   Voronezh Regional Clinical Hospital No. 1,   N. N. Burdenko Voronezh State Medical University, Avdeyev Aleksey I. ,   Voronezh Regional Clinical Hospital No. 1,   N. N. Burdenko Voronezh State Medical University
Published: January 2025

INTRODUCTION: Benign prostatic hyperplasia (BPH) belongs to the most significant urologic diseases of older men. Most studies analyze the BPH manifestations in patients with prostate-specific antigen (PSA) > 4 ng/ml. Insufficient attention is given to the analysis of the clinical course of BPH with PSA level < 4 ng/ml.
AIM: To analyze the peculiarities of the clinical course of BPH with PSA level < 4 ng/ml.
MATERIALS AND METHODS: The study included 146 patients with BPH who underwent transurethral prostate resection in the urology department of Voronezh Regional Clinical Hospital No. 1 from 2020 to 2023. Patients were divided into 6 groups depending on PSA level and medication therapy. Patients of the first 3 groups received alpha1-adrenoblockers, patients of groups 4–6 received combination therapy with alpha1-adrenoblockers and 5α-reductase inhibitors.
RESULTS: In patients of groups 2 and 3 who were on monotherapy with alpha1-adreno-blockers, the score on the international scale of prostatic symptoms (International Prostate Symptom Score, IPSS), was higher than in patients of groups 5 and 6, with combined treatment and amounted to 28.0 [23.0; 31.0] and 27.0 [23.0; 28.0], respectively, however, is statistically insignificant (p > 0.05). Acute urinary retention (OCM) was statistically significantly less frequently detected in groups 5 and 6, in 50% and 10% of cases, respectively, versus 89% (p = 0.002) and 58% (p = 0.001) of cases in groups 2 and 3 respectively. There were no statistically significant differences in the frequency of OCM in patients of groups 1 and 4. Among the concomitant diseases in patients with BPH, diseases of the cardiovascular system were more often detected.
CONCLUSION: In the studied groups of BPH patients with a low PSA value, the score on the IPSS scale did not differ statistically significantly. OZM was more common in patients with BPH who were on monotherapy with alpha-1 adreno-blockers. Diseases of the cardiovascular system prevailed among concomitant diseases in patients with BPH.
Cerebral Edema in Children and Adolescents with Diabetic Ketoacidosis: Pathophysiological Mechanisms and Clinical Presentation
Authors:   Stavropol State Medical University, Bykov Yuriy V. , Obedin Aleksandr N. ,   Stavropol State Medical University, Fischer Vasiliy V. ,   Stavropol State Medical University, Volkov Evgeniy V. ,   Stavropol State Medical University, Yatsuk Ivan V. ,   Stavropol State Medical University
Published: January 2025

INTRODUCTION: Diabetic ketoacidosis (DKA) is one of the acute and severe complications of type 1 diabetes mellitus in pediatric practice.
AIM: To analyzed based on literature data the key pathophysiological mechanisms and clinical features of cerebral edema (CE) in children and adolescents with DKA.
The paper describes the results of foreign and domestic studies dedicated to the mechanisms of development, clinical features of CE in pediatric practice. Topic-related sources from the PubMed and RSCI databases are reviewed. The search depth is 25 years.
CONCLUSION: Reviewed are the pathogenetic mechanisms underlying the development of cytotoxic, vasogenic and osmotic CE. Particular emphasis is made on the inflammation theory and the role of ischemic/hypoxic factors in the development of CE. Data are provided to describe specific clinical features of CE in children and adolescents receiving intensive care, as well as risk factors that predispose to the development of this complication. Understanding of the pathogenetic mechanisms, clinical signs CE will result in better treatment outcomes and bring down the risk of death in this category of patients.
Evaluation of Aeroponic Minitubers of Newly Released Potato Varieties under Various Spacing Combinations
Authors: Sadawarti Murlidhar J. , Buckseth Tanuja , Singh S. P. , Sharma Ashwani Kumar , Kumar Vinod , Singh R. K. , Katare Subhash , Singh Brajesh , Samadhiya R. K. , Singh Y. P. , Sharma S. K.
Published: January 2025

This study was conducted during 2020–21 to 2023–24 at ICAR-Central Potato Research Institute, Regional Station, Gwalior, Madhya Pradesh, India to compare the production potential of newly released potato varieties grown as aeroponic minitubers under different spacing combinations under net house conditions. The planting was done in 2nd week of November each year two spacing combinations 30×10 cm2 (333333 plants ha-1) 30×15 cm2 (222222 plants ha-1) and four varieties viz Kufri Ganga-Medium maturing, Kufri Lima-Medium maturing heat tolerant and Kufri Mohan -early bulking medium maturing and Kufri Sangam-medium maturing processing with plot size of 1.80m2. The trial was planted in factorial RBD with three replications with spacing combinations as main plot and varieties as sub plots. The objective was to determine the optimal spacing for maximizing yield, tuber size, and overall performance of these varieties. No significant difference in growth parameters among spacing combinations, but varietal differences were observed. 30×10 cm2 spacing recorded significantly higher total tuber number (1571 thousand ha-1) compared to 30×15 cm2 spacing (1301 thousand ha-1). Varieties Kufri Ganga, Kufri Mohan, and Kufri Sangam recorded significantly higher total tuber numbers over Kufri Lima. Study suggests that newly released potato varieties grown as aeroponic minitubers should be multiplied at 30×10 cm2 spacing to achieve a higher number of tubers. Kufri Ganga and Kufri Mohan performed better in terms of total tuber weight, while Kufri Lima and Kufri Mohan had a higher percent of medium-sized tubers by number.
Carotid Endarterectomy and Stenting of the Internal Carotid Artery in Patients with Occlusion of the Contralateral Carotid Artery
Authors: Gorshkov N. S. , Ryabukhin V. E. , Koblik A. S. , Kokov L. S.
Published: January 2025

ABSTRACT The results of studies investigating the impact of contralateral carotid occlusion (CCO) in patients with carotid stenosis who have undergone endarterectomy or stenting vary in the literature. We aimed to determine which approach is the optimal revascularization strategy for those patients.

THE AIM OF STUDY To review the current scientific literature reflecting the outcomes of patients with CCO and to determine whether the presence of CCO plays a prognostic role in perioperative outcomes in patients undergoing carotid revascularization with endarterectomy or stenting.

MATERIAL AND METHODS Literature sources from Pubmed and MEDLINE, Scopus and Cochrane information aggregators on this topic published in Russian and English between 2003 and 2023 were selected for analysis. The terms of contralateral carotid occlusion, stenting of the single carotid artery, carotid endarterectomy, endovascular treatment for stenosis of the single carotid artery, surgery of the single carotid artery, carotid and (stent or stenting) and endarterectomy and (contralateral or bilateral) and occlusion were included in the analysis.

An observational or randomized study was considered eligible for inclusion only if it met all specified inclusion criteria: (1) carotid revascularization outcomes were compared in patients with and without CCO; (2) quantitative data on clinical outcomes of interest were provided; and (3) the study was published before September 2023. Studies that did not meet any of these criteria were not eligible for inclusion. Common exclusion criteria were carotid revascularization performed concurrently with coronary revascularization, acutely developing stroke, spontaneous carotid dissection or fibromuscular dysplasia.

RESULTS 35 literature sources were analyzed. The review article presents the world experience of surgical treatment (carotid endarterectomy and stenting of the internal carotid artery) in patients with haemodynamically significant stenosis and contralateral carotid occlusion. Some papers indicate the advantages of endovascular operations in elderly patients, others carotid endarterectomy. The accumulation of experience in treatment of this category of patients should help either in optimization or in individualization of surgical tactics.

CONCLUSION Surgical intervention in patients with haemodynamically significant stenosis of the internal carotid artery and contralateral occlusion should be differentiated and have an individual approach.
Pendampingan Pengembangan Aplikasi Kompresi Gambar dalam Kegiatan Bangrap IPTEK BAPPEDA Kota Magelang
Authors: Ariyana Renna Yanwastika , Emy Setyaningsih  , Amir Hamzah
Published: January 2025

BAPPEDA Kota Magelang sebagai penanggung jawab dalam pengembangan dan penerapan ilmu pengetahuan dan teknologi di tingkat kabupaten/kota, menindak lanjuti inovasi-inovasi yang berasal dari masyarakat yang layak untuk dikembangkan. Kegiatan ini disebut sebagai Pendampingan Pengembangan dan Penerapan IPTEK (Bangrap IPTEK), yang merupakan tindak lanjut dari hasil seleksi kegiatan KRENOVA tingkat kota magelang yang telah di selenggarakan sebelumnya. hasil seleksi Bangrap IPTEK mendapatkan 6 judul inovasi yang di kategorikan layak untuk dikembangkan lebih lajut. Sebagai bentuk dukungan bagi peserta yang terpilih, BAPPEDA Kota Magelang menyediakan pendampingan intensif guna memaksimalkan hasil inovasi yang dikembangkan, sebelum di edarkan di masyarakat. Salah satu tim pengembang inovasi Bangrap IPTEK menciptakan inovasi digital berupa aplikasi kompresi gambar dengan nama “FastImageMin” yang di kembangkan untuk memperkecil ukuran gambar sebagai solusi optimalisasi ruang penyimpanan. Kegiatan pendampingan yang dilakukan berfokus pada pemberian arahan dan bimbingan kepada tim pengembang inovasi Bangrap IPTEK guna meastikan produk yang di hasilkan siap untuk digunakan dimasyarakat. Dimana hasil dari proses bimbingan yang di berikan dapat memaksimalkan inovasi yang di hasilkan oleh tim pengembang. Dari kegiatan pendampingan yang dilakukan untuk tim pengembang, dapat disimpulkan bahwa aplikasi yang dikembangkan telah siap di gunakan oleh masyarakat.
Complex-Differentiated Approach to Improving the System of Sports Training in Basketball
Authors:   Qiqihar University, Sun Haiyang
Published: January 2025

The research pursued the aim of scientific substantiation of the effectiveness of the application of pedagogical tools of complex-differentiated approach in the organization of sports training of basketball players. The theo-retical knowledge, obtained as a result of analytical activity, was applied during the experimental part of the study, providing for a pedagogical experiment, control-pedagogical testing and the use of mathematical meth-ods of statistical processing of the resulting data. The experimental part of the study was carried out between September and November 2024 with the participation of 14 basketball players aged 17 years. The criterion for evaluating the results was the level of technical and tactical preparedness. The general theoretical significance of the obtained research results is determined by the provision of an evidence base indicating the need to use pedagogical tools of an integrated and differentiated approach in planning and direct organization of the train-ing process in the system of long-term sports training of basketball players. This study has time constraints that do not allow us to draw final conclusions, therefore it requires additional empirical verification in training prac-tices, however, it determines the vector of subsequent scientific research in the context of the research topic.
Artificial Intelligence in Public Control: Limits of Admissibility (Legal Aspect)
Authors:   Kuban State University, Potapenko Sergey V. , Pchelintsev Artem S. ,   RUDN University, Goncharov Vitaly V. ,   Association of Independent Human Rights Defenders, Petrenko Elena G. ,   Kuban State Agrarian University named after I.T. Trubilin, Cheshin Andrey V. ,   Orsk Humanitarian-Technological Institute – Branch of the Orenburg State University
Published: January 2025

The article delves into the legal aspect of the limits of admissibility of the artificial intelligence use in the im-plementation of public control. The authors substantiate the role and significance of this socio-legal institution, on the one hand, as an essential condition for the preservation and development of society and the state, and on the other hand – as a key legal guarantee for the realization, protection and defense of both the system of constitutional principles (first of all, people’s power and participation of citizens in the management of state affairs) and the entire system of rights, freedoms and legitimate interests of individuals and legal entities. The paper examines the legal limits of the permissibility of using artificial intelligence technologies in management, control and supervisory activities using the example of the Institute of public control (legal and other). The arti-cle substantiates the position that artificial intelligence technologies in these types of activities can and should be used only with human participation, under human control, and subject to respect for the rights, freedoms, and legitimate interests of individuals and legal entities. The main legal problems that subjects of public control will face when using artificial intelligence technologies in the organization and implementation of public control activities are identified and investigated, in particular, concerning the lack of fixing in the civil legislation the limits of the use of artificial intelligence technologies in the Russian Federation; weak development in the sci-entific legal doctrine of the concept and content of these limits; the lack of a technological base for autonomous production in Russia. The authors have developed and substantiated a system of measures to resolve them.
Values and Identities in the City-Text Palette
Authors:   Moscow City Universit, Kozlova Yulia V. , Savchenko Irina A. ,   Moscow City Universit, Kuzmin Vladimir D. ,   Moscow City Universit
Published: January 2025

The concept of the city-text is substantiated as a methodological model for examining the value-based, motiva-tional, and meaningful dynamics of urban life. This article elucidates how the political contextuality of the city’s sign system delineates the unique subjective positioning of individuals and groups as actors within urban dis-course. The study explores the polysubjective integrative foundations and illustrates their impact on the trans-formations of personal, socio-cultural, and network identities of modern urbanites. It is emphasized that the concept of the city-text is shaped by linguistic, cultural, and social factors, among which urban identity and pol-ysubjectivity hold particular significance. Empirical research data – derived from sociological surveys and focus group interviews – are presented in the context of the stated model, revealing the nature of value and identity transformations in the dynamics of urban discourse. Based on the obtained results (theoretical and applied), the discourse of the city is defined as an intergenerational social relay race, the content of which is a multidi-mensional construct of the urban text unfolding at the intersection of subject fields and defining the parameters of the social identification matrix.
Pausanias y la pintura mitológica de Fernanda Facciolli
Authors: Navarrete Orcera Antonio Ramón
Published: January 2025

En este trabajo se estudia una exposición de pintura mitológica celebrada en 2017 en la Fortaleza Vieja de la isla de Corfú. Los artistas son Fernanda Facciolli (Venecia 1950), principalmente, y su esposo Emmet, que, llevados por su pasión por la arqueología y por Pausanias, han recorrido gran parte de la geografía griega (especialmente, Beocia y Corfú para la ocasión) tratando de demostrar que los personajes mitológicos son, en realidad, elementos de la naturaleza y que la religión dominante en la Edad del Bronce era de tipo matriarcal.
Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues
Authors: Burmańczuk Artur , Osypiuk Monika , Polska Bożena , Kunicki Dominik , Kocik Marcin , Grzęda Karol , Markiewicz Włodzimierz , Yilmaz Oktay , Grabowski Tomasz
Published: January 2025

Introduction

Sulphonamides are some of the most widely used antimicrobial drugs in the treatment of bacterial diseases in pigs. The study was conducted to compare the total exposure of tissue to a group of active substances in a single formulation and evaluate the impact of the volume of distribution, lipophilicity and tissue half-life of sulfadimethoxine, sulphathiazole, sulphamethazine and sulphacetamide in two different veterinary drug formulations – Polisulfalent, which was preparation A, and Polisulfamid, which was preparation B.

Material and Methods

Each tested therapeutic preparation was administered to 15 piglets of the Polish Landrace breed. To assume general exposure expressed as the sum of all observed concentrations of all active substances, semi-log regression analyses were performed for both formulations.

Results

The estimated tissue half-life was 21.19 h for preparation A and 17.36 h for preparation B. The comparison of the semi-log regression parameters shows that formulation B’s Y-intercept and slope values were higher than formulation A’s. The upper-bound CI for the Y-intercept and slope value of formulation B was higher than those of formulation A, at 38.7 and 20.8%, respectively.

The lower-bound CI for the Y-intercept and slope value of formulation B was also higher than those of formulation A, at 20.6 and 42.9%, respectively.

Conclusion

Current observations lead to the conclusion that in late-stage drug elimination, it is not the blood half-life, but rather a drug’s volume of distribution which is key in determining the clearance period, this volume being dependent on the physicochemical characteristics of the drug.
Exploring Climate Change, Perceptions, and Adaptive Measures among Dairy Producers in Kiruhura District, Uganda
Authors: Byamukama Obed , Agbolosoo John Atsu
Published: January 2025

The continuous evidence of climate change highlights the fact that it is a critical worldwide issue with potentially disastrous consequences for agricultural systems and the livelihoods of socioeconomically disadvantaged societies. This research explores dairy producers’ perceptions of temperature and precipitation changes, their adaptation strategies, and the influencing factors behind these strategies. Data on dairy producers' perceptions was collected by means of a household survey and analyzed utilizing descriptive statistics and graphical representations. Climate data for the study area (1985–2014) was sourced from the Uganda National Meteorological Authority. It was then analyzed using trend analysis. Results from trend analysis were then used to compare with dairy farmers’ responses. Notably, the results show significant agreement between dairy farmers' perceptions and empirical climate data, indicating a clear understanding of climate dynamics. This understanding informs their adaptation practices, which have proven to be diverse and context dependent. These practices include the creation of animal pastures, reforestation, reducing the size of herds through sales, utilizing drought-resistant breeds, and purchasing feed additives for livestock. In addition, the study found that access to credit, household size, education level, and gender are important factors affecting pastoralists' adaptability. These results underscore the importance of recognizing and leveraging farmers' experiential knowledge when developing targeted climate adaptation strategies for specific localities. By bridging the gap between perception and reality, this research provides valuable insights for policymakers for developing tailored climate adaptation strategies and improving resilience within dairy-producing communities in response to climate change
Revitalisasi Pancasila dalam Pendidikan sebagai Upaya Penguatan Karakter Nasional di Kalangan Mahasiswa
Authors: Tirtayama Sakha Aditya , Ediyono Suryo , Muzzaki Naufal , Diena Naila Aulia , Maharani Anisa Zahra , Assidiqi Fasya Amir , Maryam Syahla Aqila
Published: January 2025

Pancasila sebagai dasar negara Indonesia memiliki peran penting dalam membentuk karakter nasional generasi muda, khususnya mahasiswa. Namun, tantangan globalisasi dan perkembangan teknologi mempengaruhi relevansi dan pemahaman mahasiswa terhadap nilai-nilai Pancasila. Penelitian ini mengevaluasi implementasi pendidikan Pancasila di perguruan tinggi dalam konteks globalisasi dan teknologi. Menggunakan metode survei kuantitatif, penelitian ini mengidentifikasi tantangan yang dihadapi mahasiswa dalam memahami dan menginternalisasi nilai-nilai Pancasila. Hasil survei dari 100 responden menunjukkan bahwa meskipun mayoritas mahasiswa mengikuti mata kuliah Pancasila, banyak yang merasa materi tidak sepenuhnya relevan dengan kehidupan sehari-hari. Tantangan lainnya meliputi metode pengajaran yang kurang interaktif dan cenderung teoritis. Teknologi telah digunakan dalam pembelajaran, tetapi masih perlu ditingkatkan pemanfaatannya. Kurangnya minat mahasiswa dan pengaruh budaya asing menjadi hambatan utama. Rekomendasi meliputi metode pengajaran yang lebih interaktif, penggunaan teknologi digital, dan integrasi nilai Pancasila dalam berbagai kegiatan kampus untuk meningkatkan keterlibatan dan pemahaman mahasiswa.
Implementasi Pendidikan Seni Tari sebagai Sarana Pengembangan Kecerdasan Emosional pada Anak Usia Dini di RA Amalia Darma Kecamatan Sunggal Kabupaten Deli Serdang
Authors: Zannatunnisya Zannatunnisya , Rozana Salma , Parapat Asmidar , Rambe Almanah
Published: January 2025

Tulisan ini bertujuan untuk menganalisis implementasi pendidikan seni tari sebagai sarana pengembangan kecerdasan emosional pada anak usia dini di RA Amalia Darma, Kecamatan Sunggal, Kabupaten Deli Serdang. Kecerdasan emosional merupakan aspek penting dalam perkembangan anak, yang mencakup kemampuan mengenali, mengelola, dan mengekspresikan emosi secara sehat. Metode penelitian yang digunakan adalah penelitian kualitatif deskriptif dengan pendekatan observasi, wawancara, dan dokumentasi. Subjek penelitian terdiri dari guru seni tari, siswa, dan orang tua sebagai pihak yang berperan dalam proses pendidikan anak. Hasil penelitian menunjukkan bahwa pendidikan seni tari berkontribusi positif terhadap pengembangan kecerdasan emosional anak. Melalui seni tari, anak-anak diajarkan untuk memahami dan mengekspresikan emosi mereka, berinteraksi dengan teman-teman sebaya, serta mengembangkan kepercayaan diri dan empati. Aktivitas tari juga membantu anak-anak dalam mengelola stres dan meningkatkan kemampuan konsentrasi. Guru memainkan peran penting dalam membimbing dan menciptakan lingkungan yang mendukung proses belajar melalui seni tari. Dukungan dari orang tua juga berperan dalam memperkuat perkembangan emosional anak di rumah. Kesimpulannya, pendidikan seni tari di RA Amalia Darma dapat menjadi media yang efektif dalam mengembangkan kecerdasan emosional anak usia dini. Penerapan program ini diharapkan dapat menjadi model bagi lembaga pendidikan anak usia dini lainnya untuk meningkatkan aspek emosional anak melalui pendekatan seni.
Melacak Jejak Pesanggrahan Terakhir Jenderal Sudirman di Magelang Melalui Dokumenter Expository
Authors: Amelia Rizky , Tumimomor Anthony Y.M
Published: January 2025

Jenderal Sudirman merupakan tokoh pejuang pasca kemerdekaan Indonesia. Jenderal Sudirman terkenal dengan taktik perangnya yaitu gerilya, namun taktik perang gerilya ini menguras banyak tenaga pasukan dan membuat Jenderal Sudirman penyakit yang dideritanya menjadi kambuh dan semakin parah. Jenderal Sudirman kembali ke Yogyakarta untuk menjalani perawatan hingga akhirnya pindah ke Magelang untuk mempercepat pemulihannya. Rumah tempat Jenderal Sudirman menjalani pemulihan sampai akhirnya meninggal, saat ini beralih fungsi menjadi museum. Berdasarkan penelitian awal serta wawancara yang dilakukan, didapat hasil bahwa  sebagian besar masyarakat yang tidak mengetahui mengenai informasi ini terutama masyarakat Magelang. Sehingga perlu adanya media informasi yang mampu menceritakan mengenai hal ini, adapun media yang dapat digunakan adalah film dokumenter. Metode penelitian yang digunakan adalah metode kualitatif dan dengan menerapkan strategi linear dalam proses perancangannya. Hasil dari film dokumenter akan menjadi media informasi yang menarik untuk menggambarkan jejak pesanggrahan terakhir Jenderal Sudirman di Magelang kepada masyarakat Magelang secara khusus dan masyarakat Indonesia secara umum.
Menghargai Peran Guru dalam Perspektif Al-Qur'an dan Hadits Pada Hari Guru
Authors: Putri Umi Amelia , Oskar Ruani , Muhajirin Muhajirin , Mukmin Mukmin
Published: January 2025

Pendidikan merupakan fondasi bagi pembangunan suatu bangsa, dan guru adalah garda terdepan dalam proses tersebut. Dalam perspektif Al-Qur'an dan Hadits, peran guru diakui sebagai posisi yang sangat mulia. Penelitian ini bertujuan untuk mengeksplorasi bagaimana ajaran Islam menekankan pentingnya peran guru dan bagaimana hal ini dapat diterapkan dalam kehidupan sehari-hari, terutama pada perayaan Hari Guru. Dengan menggunakan metode studi literatur, penelitian ini mengumpulkan data dari berbagai sumber untuk memberikan gambaran yang komprehensif tentang penghargaan terhadap guru dalam konteks keagamaan. Hasil penelitian menunjukkan bahwa penghargaan terhadap guru tidak hanya penting secara sosial, tetapi juga merupakan bagian dari implementasi ajaran Islam yang lebih luas.
Leadership Strategy Of School Principal In Improving Teacher Professionalism At Al-Yasiriyah Educational Foundation
Authors: Tanjung Rizka Yulia , Harahap Muhammad Yunan
Published: January 2025

This research aims to analyze the leadership strategies of school principals in improving teacher professionalism at Al-Yasiriya Brothers Educational Foundation. Using a descriptive qualitative research method with pedagogical and sociological approaches, this study involves school principals, teachers, and students as primary data sources. Data collection is conducted through direct observation, in-depth interviews, and documentary studies. Data analysis employs Miles and Huberman techniques, which include three stages: data reduction, data presentation, and conclusion drawing, with triangulation as a data validation method. The results reveal that school principals implement several key strategies to improve teacher professionalism. First, teacher competency development is carried out through ongoing professional training programs and workshops. Second, the creation of a collaborative working environment that fosters innovative learning. Third, the implementation of regular academic supervision to enhance teaching quality. Fourth, the application of performance-based reward systems to boost teacher motivation. The school principals also demonstrate transformational leadership by leading through discipline, integrity, and commitment to the foundation's vision. Despite facing challenges such as limited budgets and resistance to change, school principals have overcome these obstacles through effective communicative and collaborative approaches. This research concludes that the strategic leadership of school principals plays a fundamental role in improving teacher professionalism. Based on these findings, it is recommended to strengthen the synergy between school principals, teachers, and the foundation to create a quality and sustainable educational ecosystem
Introduction To Basic Financial Concepts For Kindergarten Children At Tunas Kemuning Kindergarten, Kemuning Muda Village, Siak Regency
Authors: Wariam Inge , Latifah Anni , Indriani P Theresia , Wahyuni Sri , Talis Novrida , Rasiyem Rasiyem , Agustina Yumniati
Published: January 2025

Early financial literacy is an important foundation for developing financial awareness and skills. This program was carried out through the Community Service Program (KKN) at Tunas Kemuning Kindergarten, Kemuning Muda Village, in October 2024. This program aims to introduce basic financial concepts to kindergarten children and improve teacher competency in school financial management. This program uses a multi-method approach, including interviews, interactive socialization, and practical training. The program results showed that children better understood the basics of counting, saving habits, recognition of types of money, and simple financial transactions. Teachers reported increased knowledge of financial management and the ability to apply transparent bookkeeping methods. Although the results were positive, the limited time required to implement the program was a challenge that limited its impact. This program emphasizes the importance of early financial education and teacher training in financial management. Recommendations for future initiatives include extending the duration of the program, integrating financial literacy into the early childhood education curriculum, and involving parents to strengthen learning at home. The uniqueness of this program lies in its community-based approach that combines children's financial literacy education with increasing teacher capacity in financial management.
Zeitenwende Through the Lens of Olaf Scholz’s Government Strategic Documents
Authors: Sokolov A. P. , Protsenko S. E.
Published: January 2025

This study examines German doctrinal documents issued under the government of Olaf Scholz in the context of the “Zeitenwende” (turning point) proclaimed in 2022. Key documents analyzed include the National Security Strategy, Guidelines for Feminist Foreign Policy, Strategy on China, and Defense Policy Guidelines. Of particular interest are the ongoing transformations in Germany's strategic culture, which are unprecedented in scope and aim to position the Federal Republic as a significant actor in military policy. In response to Russia's military intervention in Ukraine, Berlin has increasingly emphasized the military dimension of its policy, including arms deliveries to Kyiv—an action that marks a departure from the postwar principle of refraining from supplying weapons to conflict zones.The article explores how intra-German debates on military and political issues are reflected in these strategic documents. The participants in these debates can be broadly categorized into three groups: proponents of both the “Zeitenwende” and the government's associated policies; supporters of the “Zeitenwende” who dissent on the methods or tools of implementation; and opponents of the “Zeitenwende” in principle. Using qualitative content analysis, the study identifies contradictions within the documents and inconsistencies in the implementation of Berlin's declared objectives. Many formulations in the documents are characterized by ambiguity, allowing for future revisions or additions. Notably, the Green Party exerts significant influence over the content, promoting a bellicose rhetoric and advocating for an expanded understanding of security issues.The findings suggest that Germany's practical approach remains measured and cautious. However, the incorporation of the “Zeitenwende” principles into strategic documents ensures their longevity, making it unlikely that any future government coalition will disregard these foundational shifts in Germany's military and foreign policy.
Evolution of the U.S. Republican Party’s Foreign Policy Platform and Its Implementation Challenges (2000–2004)
Authors: Sukhoverkhov K. K.
Published: January 2025

American politics is shaped by numerous variables that influence the development of both domestic and foreign policy. Among these, the formulation of party platforms plays a critical role in determining the policy direction of U.S. administrations. While it is often assumed that party platforms diverge from actual policy outcomes, recent research suggests otherwise in the U.S. context. Party platforms serve as official documents articulating a party’s ideological, political, and economic principles, including pre-election promises and foundational stances on various issues for the electoral cycle, typically spanning four years. This article examines the process of party platform formulation, focusing on the Republican Party's platform in 2000 and its subsequent implementation.During the 1990s, the Republican Party initiated a reformation of its platform following a series of electoral defeats in presidential races. This restructuring, led by figures such as George W. Bush and shaped by influential conservative think tanks, embraced a strategy known as "compassionate conservatism." However, the actual trajectory of U.S. administrations often diverges from the initial platform due to unforeseen circumstances. This phenomenon was particularly evident during the presidency of George W. Bush, where foreign policy experienced a significant shift towards neoconservative influences.The events of September 11, 2001, acted as a catalyst, fundamentally reshaping foreign policy objectives and altering public sentiment towards the Bush administration, as highlighted by sociological studies. These developments led to substantial changes in the nation's regional foreign policy priorities, reflecting the dynamic interplay between pre-election platforms and the realities of governance.
Public Services With Information Technologies in the Strategic Digital City Context: Curitiba, Brazil
Authors: Chu Geane Derosso , Torquato João Vitor , Gallego Andrés Ruiz , Rezende Denis Alcides , Okon Godswill Udoh
Published: January 2025

Objectives: The research objective is to analyze the public services with information technology in the strategic digital city context.
 
Theoretical Framework: Concepts based on the themes: strategic digital city; public services with information technology; and conceptual relationships.
 
Method: The research methodology included a case study in the city of Curitiba, considering the research protocol with 1 construct and 3 variables.
 
Results and Discussion: The results show that the city of Curitiba has 25 services with information technology, in which 20% were associated with thematic construction, 16% with thematic health, 12% with thematic municipal and urban services, 8% with thematic mobility and transit, and 4% with thematic trade, communication, education, sports, security and work. The conclusion highlights that a strategic digital city project, as an innovative urban management model, can assist in the planning of strategies, the design of public services and the integration of information technology resources, considering the participation of citizens, which corroborates for more adequate and sustainable urban management in cities.
 
Research Implications: Contemporary cities, in addition to being considered physical spaces, require digital infrastructure for functioning, through the use of information technology resources, considering the social and environmental approaches.
 
Originality/Value: The concept and model of strategic digital city projects are original and of adequate value to the citizens quality of life.
SIMPLEX TRANSPORTATION METHOD FOR DETERMINING TRANSSHIPMENT OF CLOTHING RAW MATERIALS
Authors: Hasbiyati Ihda , Wahyuni Syahputri , Agustiarini Efni , Amini Mufti Syifa , Ahriyati Ahriyati
Published: January 2025

Tujuan dari penulisan ini adalah untuk memberikan gambaran bagaimana penyelesaian masalah transshipment pengiriman bahan baku pakaian dengan metode pengangkutan simplex. Untuk menentukan solusi optimal permasalahan transshipment dengan memperhatikan koefisien biaya pengangkutan. Proses awal penyelesaian masalah ini dengan mengilustrasikan cara mengubah bilangan fuzzy menjadi bilangan tegas menggunakan fungsi rangking yang kuat, kemudian untuk mencari basis awal menggunakan metode aproksimasi Vogel, kemudian menggunakan metode transportasi simpleks untuk menguji basis awal, sehingga optimal hasil diperoleh. Sehingga dapat diambil kesimpulan bahwa satuan pengiriman barang dari satu sumber ke sumber lain dengan menggunakan metode transportasi simpleks merupakan solusi optimal untuk mencari nilai minimum dari masalah transshipment.