bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Nomogram and Patterns of Use of FOLFIRI-Aflibercept in Advanced Colorectal Cancer: A Real-World Data Analysis
Authors: Fernández Montes Ana , López López Carlos , Argilés Martínez Guillem , Páez López David , López Muñoz Ana María , García Paredes Beatriz , Gutiérrez Abad David , Castañón López Carmen , Jiménez Fonseca Paula , Gallego Plazas Javier , López Doldán María Carmen , Martínez de Castro Eva , Sánchez Cánovas Manuel , Tobeña Puyal María , Llorente Ayala Beatriz , Juez Martel Ignacio , López Flores Mariana , Carmona-Bayonas Alberto
Published: May 2019

Introduction

The VELOUR study evaluated the efficacy and safety of adding aflibercept to FOLFIRI (fluorouracil, leucovorin, irinotecan) in second-line therapy for metastatic colorectal cancer (mCRC). However, a nomogram that can stratify patients according to prognosis is unavailable, and the frequency and effect of the pragmatic use of modified schedules in actual practice remains unknown.

Method

The sample consists of 250 patients with mCRC treated with aflibercept and irinotecan-based chemotherapy at nine Spanish academic centers between January 2013 and September 2015. The result of a Cox proportional hazards model regression for overall survival (OS), adjusted for covariates available in daily practice, was represented as a nomogram and web-based calculator. Harrell's c-index was used to assess discrimination.

Results

The prognostic nomogram for OS includes six variables: Eastern Cooperative Oncology Group performance status, tumor location, number of metastatic sites, mutational status, better response to previous treatment(s), and carcinoembryonic antigen. The model is well calibrated and has acceptable discriminatory capacity (optimism-corrected c-index, 0.723; 95% confidence interval [CI], 0.666–0.778). Median OS was 6.1 months (95% CI, 5.1–8.8), 12.4 months (95% CI, 9.36–14.8), and 22.9 months (95% CI, 16.6–not reached) for high-, intermediate-, and low-risk groups, respectively. Age, comorbidity, or use of modified FOLFIRI regimens did not affect prognosis in this series. Grade 3–4 adverse events were less common following modified schedules. The admission rate because of toxicity was higher in ≥65 years (9.7% vs. 19.6%; odds ratio, 2.26; p = .029).

Conclusion

We have developed and internally validated a prognostic model for use in individuals with colorectal cancer initiating therapy with FOLFIRI-aflibercept to predict both OS and the effect of pragmatic modifications of the classic regime on efficacy and safety. This can aid in decision making and in designing future trials.
Azerbaycan Serbest Şiiri ve Şairleri Üzerinde Nâzım Hikmet Etkisi
Authors: AHMADOV Ramil
Published: May 2019

1928 yılında Nâzım Hikmet’in Bakü’de yayımlanan Güneşi İçenlerin Türküsü adlı ilk şiir kitabı,Azerbaycan edebiyatında büyük yankı uyandırmıştır. Bu kitapla Azerbaycan şairleri toplu halde farklı şiirformu ile ilk defa karşılaşmışlardır. Ali Nâzım, Süleyman Rüstem, Ekrem Cafer, Mikail Refili gibi şair veeleştirmenler bu kitap üzerine denemeler yazmıştır.Azerbaycan edebiyatında 1927-1928’lere kadar çeşitli dergi ve gazetelerde serbest şiir örnekleriylekarşılaşılsa da, bunlar tam anlamıyla serbest şiir tanımına uygun gelmemektedir. Nâzım Hikmet’in “Şairolabilirdin, profesör oldun” dediği Mikail Refili, bir yazısında Maarif ve Medeniyet dergisinde yayımlananüç dört serbest şiir örneğinde Nâzım Hikmet etkisi olduğunun altını çizer. Nâzım Hikmet, Azerbaycanşairlerini şiirleri ve hayatı ile en çok etkileyen ediplerden biridir. Hem sağlığında, hem de ölümününardından Ali Nâzım, Mikail Refili, Semed Vurgun, Süleyman Rüstem, Memmed Rahim, Medine Gülgün,Bahtiyar Vahapzade, Neriman Hasanzade gibi 20. yüzyıl Azerbaycan şiirinin önde gelen isimleri NâzımHikmet’e şiirler adamışlardır.Bu çalışmada öncelikle 1920-1930’lu yıllarda Azerbaycan edebiyatında Nâzım Hikmet’in etkisiylekaleme alınan serbest şiirlerin yazılış süreci işlenecektir. Ardından Azerbaycan şairlerinin 1950’lerde veölümünden sonra Nâzım Hikmet’e adadıkları şiirler incelenecektir.
M.Ü. Türkiyat Araştırmaları Enstitüsü’nün Düzenlediği Türk-Rus Türkologlar Çalıştayı 3 Ocak 2019’da İstanbul (Türkiye)’da Gerçekleşti.
Authors: ŞAHİN Liaisan
Published: May 2019

M.Ü. Türkiyat Araştırmaları Enstitüsü’nün Düzenlediği Türk-Rus Türkologlar Çalıştayı 3 Ocak 2019’da İstanbul (Türkiye)’da Gerçekleşti.
Zaman pencereli ve değişken başlama zamanlı bir araç rotalama problemi için sütun türetme temelli mat-sezgiseller
Authors: KÜÇÜKAYDIN Hande
Published: May 2019

Bu çalışmada, araçların kullanıldıkları süreye bağlı maliyetlerin oluştuğu ve araçların depodan başlama zamanının
bir karar verici tarafından belirlendiği zaman pencereli bir araç rotalama
problemi ele alınmaktadır. Problemi etkin bir şekilde çözmek için biri
yinelemeli yerel arama meta-sezgiselinden, diğeri değişken komşuluk arama
meta-sezgiselinden yararlanan iki sütun türetme temelli mat-sezgisel
geliştirilmiştir.  Geliştirilen
mat-sezgiseller literatürden alınarak türetilen 87 örnek üzerinde her
mat-sezgisel her örnekte 3 kere koşularak test edilmiştir.  Bilgisayımsal sonuçlar iki mat-sezgiselin de
etkinliğini kanıtlamış, ancak değişken komşuluk arama meta-sezgiseli kullanan
mat-sezgiselin daha başarılı olduğunu göstermiştir. Bu sayede kesin bir
yöntemle makul bir ana işlemci zamanında çözülemeyen büyük ölçülü problemler için
çok kısa bir zaman içerisinde iyi bir olurlu çözüm elde etmek mümkün hale
gelmiştir.
Hasargörebilirlik analizlerinde yer hareketi veri setine ve şiddet ölçüsüne bağlı epistemik belirsizliğin değerlendirilmesi
Authors: KALE Özkan
Published: May 2019

Yapıların hasargörebilirlik analizlerinin ana unsurlarını yer hareketi
veri setinin derlenmesi, yapısal analiz ve yer hareketi şiddet ölçüsü seçimi olarak
sıralamak mümkündür. Bu çalışmada, hasargörebilirlik analizlerinde deprem veri
seti ve şiddet ölçüsü seçimine bağlı olarak ortaya çıkan epistemik belirsizlikler
değerlendirilmiştir. Bu amaçla, dört farklı deprem veri seti ve seçilen üç
farklı şiddet ölçüsü için bina türü yapı simülasyonlarına ait hasar potansiyeli
eğrileri iki farklı yaklaşıma göre geliştirilmiş ve olası farklılıklar
incelenmiştir. Hasar potansiyeli eğrileri ve deterministik deprem senaryoları
kullanılarak yapılan detaylı değerlendirmeler derlenen deprem veri setleri,
şiddet ölçüsü seçimi ve hasar potansiyeli eğrilerinin türetilmesinde uygulanan
yöntemlerin sonuçları belirli düzeylerde etkileyebileceğini göstermiştir.
Bununla birlikte sonuçları etkileyen en etkin parametrenin şiddet ölçüsü olduğu
ve efektif şiddet ölçüsü seçiminin hasargörebilirlik analizlerindeki epistemik
belirsizliği alt seviyelere indirgeyebileceği sonucuna ulaşılmıştır.
Türbülans parametrelerinin ölçümü ve türbülans kinetik enerjisinin oksijen transferine etkisi
Authors: KÖSE Ömer , HAS Ali
Published: May 2019

Sığ bir dağ akarsuyunda derinlik boyunca ve bir kaya
etrafındaki akışın türbülans özelliklerini incelemek amacıyla deneysel bir
çalışma yapılmıştır. Türbülans, hidrolik ve ekolojik süreçlerde önemli  rol oynar, 
her zaman üç boyutlu olduğundan, hesaplamalar her üç yöndeki akım
değerleri için yapılmıştır. Lazer Doppler velocimeter (LDV) ve akustik Doppler
velocimeter (ADV) gibi yüksek çözünürlüklü hız ölçüm cihazlarının üretimini
takiben dünyadaki türbülans araştırmaları hız kazanmıştır. Bu çalışmadaki
deneyler dört bileşenli bir ADV kullanılarak yapılmıştır. Sapınç (çalkantı)
hızları, varyanslar, kök ortalama kareleri, türbülans şiddetleri, Reynolds
gerilmeleri, integral zaman ölçekleri, integral uzunluk ölçekleri ve türbülans
kinetik enerji  dağılımları, su derinliği
boyunca ve bir kayanın çevresinde hesaplanarak yorumlanmıştır. Korelasyon ve
spektral yoğunluk fonksiyonları hazırlanmış ve türbülanslı çevrintilerin
yaklaşık boyutları hesaplanmıştır. Bu araştırmanın nispeten yeni bir yönü,
türbülans kinetik enerji ve çözünmüş oksijen konsantrasyonu arasındaki
ilişkinin vurgulanması ve belirlenmesidir.
Derin öğrenme yöntemleriyle dermoskopi görüntülerinden melanom tespiti: Kapsamlı bir çalışma
Authors: YILDIZ Oktay
Published: May 2019

Cilt
kanseri yaygın görülen ve tedavi edilmemesi durumunda ölüme neden olan ciddi
bir hastalıktır. Melanom ise nadir görülmesine rağmen ölüme en çok neden olan
cilt kanseri türüdür. Tüm hastalıklarda olduğu gibi cilt kanserinin erken ve
doğru tespit edilmesi hayati önem taşımaktadır.  Bilgisayar destekli tanı sistemleri cilt
kanseri tespitinde hekimlere ve hastalara yardımcı olabilir. Bilgisayar
destekli tanı sistemlerinde özellikle makine öğrenmesi ve derin öğrenme
algoritmaları etkin bir şekilde kullanılmaktadır. Gerçekleştirilen bu çalışmada
cilt kanseri türü olan melanom için otomatik tanı koyabilecek bir sistem
önerilmektedir. Melanom tanısı için tasarlanan C4Net derin sinir ağ modeli ile
beraber literatürde ön plana çıkmış AlexNet, GoogLeNet, ResNet, VGGNet derin
öğrenme algoritmaları ve Yapay sinir ağları, En yakın komşu algoritması ve
Destek vektör makinesi gibi geleneksel makine öğrenmesi algoritmalarını da
kapsayan detaylı bir deneysel çalışma yapılmıştır. Gerçekleştirilen deneysel
çalışmalarda melanom tanısı için tasarlanan C4Net derin sinir ağ modeli diğer
yöntemlere göre daha yüksek doğrulukta sınıflandırma başarısı göstermiştir.
A baseline for context-aware system for safety messages dissemination in VANETs
Authors: Yáñez Alexis , Céspedes Sandra , Rubio-Loyola Javier
Published: May 2019

Vehicular ad-hoc networks (VANETs) are mobile networks with highly dynamic contexts of operation. The design and application of context-aware systems could be critical to enhance the performance of protocols deployed in VANETs, which depend on both network and traffic conditions, to detect hostile communication environments, as well as to offer a novel way to make decisions in real-time. In this paper, we present a baseline study for the design of a context-aware system for dissemination of safety messages in VANETs. We model a realistic vehicular intersection and perform extensive simulations to evaluate two well-known dissemination mechanisms, namely the Slotted 1-persistence and the Traffic Adaptive Data Dissemination (TrAD) Protocol, with a set of parameters according to different operation scenarios. We show how the dissemination mechanisms’ performance could be improved, or worsened, by choosing a different set of parameter values. By characterizing the operation scenarios, it is possible to adequate the parameters of the dissemination mechanism with the values that work best in a given context, improving in this way the general performance of the dissemination mechanisms under study.
Doppler spectrum measurements of vehicular radio channels using a narrowband sounder
Authors: Gómez-Vega Carlos A. , Gutiérrez Carlos A. , Jaime-Rodriguez Jose J. , Vázquez-Castillo Javier , Campos-Delgado Daniel U. , Luna-Rivera Jose M. , Díaz Ibarra Miguel A.
Published: May 2019

This paper describes the implementation of a narrowband sounder for Doppler power spectrum (DPS) measurements of vehicular communication channels. The narrowband channel sounder is implemented using general purpose equipment, making such measurement platform easy to replicate for didactic and research purposes. To demonstrate the practical value of this framework, a measurement campaign was conducted to obtain empirical information about the spectral characteristics of vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) multipath radio channels in the 700 MHz band. The collected data were processed to compute the average Doppler shift and the Doppler spread of the measured channels. The obtained results show that the spectral properties of frequency-dispersive vehicular radio channels can be effectively analyzed using narrowband sounding principles.
Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia
Authors: Herrera-Toro Natalia , Peña-Aguirre Laura , Arango-Rave María Elena
Published: May 2019

Objetivo: describir la epidemiología y los resultados en el manejo de los niños menores de 15 años con el diagnóstico de tumor de Wilms (TW) en dos hospitales de alto nivel de complejidad en un período de 12 años.Métodos: estudio de seguimiento a una cohorte retrospectiva. Se revisaron las historias clínicas de pacientes con diagnóstico de TW entre enero de 2005 y mayo de 2017, buscando información centrada en edad, forma de presentación, confirmación histopatológica y estratificación del tumor, tipo de tratamiento ofrecido y desenlaces en el seguimiento relacionados con recaída y supervivencia.Resultados: en total se encontraron 84 pacientes con el diagnóstico de TW, con un promedio de edad de presentación de 3 años. Predominó el estadio III al momento del diagnóstico y la principal presentación fue masa abdominal. El 8,3 % de los pacientes tuvieron histología desfavorable. El tiempo promedio de supervivencia libre de recaída fue 97 meses. A los 108 meses después del diagnóstico, la supervivencia fue del 71 %. En nuestros hospitales se realiza nefrectomía inicial (protocolo COG/NWTS). El 39 % de los pacientes fueron sometidos a quimioterapia prequirúrgica, la cual se rigió en el 72,7 % con el protocolo SIOP y 27,3 % con el COG/NWTS.Conclusiones:en los dos hospitales analizados, el manejo del TW se rige por el protocolo del COG/NWTS con nefrectomía inicial y posterior quimioterapia. Un grupo de pacientes son llevados a quimioterapia prequirúrgica con las mismas indicaciones descritas en el protocolo americano. El diagnóstico de nuestros pacientes es con mayor frecuencia en estadios avanzados. La supervivencia en esta serie, 71 %, es menor que la reportada en la literatura mundial, 93 %.
La formación de traductores en Hispanoamérica: un vistazo a los programas de grado en traducción en seis instituciones de Argentina, Colombia y Venezuela
Authors: Gómez Norman Darío
Published: May 2019

Como parte de la investigación doctoral, “La enseñanza de la traducción en pregrado universitario en Hispanoamérica”, y ante la escasa y dispersa existencia de trabajos investigativos sobre la formación de traductores en esa parte del mundo, este artículo ofrece un panorama de la situación actual de la enseñanza de la traducción, a nivel de grado, con base en la información de seis instituciones en tres países de la región: Argentina, Colombia y Venezuela. A partir de estudios de casos virtuales, de carácter exploratorio-descriptivo, comparamos y analizamos los planes de estudio de los programas investigados y las situaciones educativas en torno a ellos. Adicionalmente, realizamos encuestas y entrevistas para indagar sobre las opiniones de los estudiantes, egresados y profesores respecto a las prácticas y experiencias académicas desarrolladas en los programas respectivos. La información recolectada nos permite presentar una mirada cercana, aunque no exhaustiva, de la situación alrededor de la enseñanza de la traducción en cada institución. Sin embargo, por desprenderse de una investigación principalmente cualitativa, cuyos datos constituyen una muestra ‘no probabilística’, el presente artículo no pretende extrapolar los resultados obtenidos en el estudio a todos los entornos educativos, ni generar respuestas concluyentes sobre la enseñanza de la traducción en el contexto hispanoamericano. Más bien, se busca ofrecer un punto de partida para investigaciones futuras, y de mayor cobertura, sobre la formación de los traductores en Hispanoamérica, siempre en procura de una mayor visibilidad de la profesión en el ámbito regional y global.
A bi-objective integer programming model for locating garbage accumulation points: a case study
Authors: Rossit Diego Gabriel , Nesmachnow Sergio , Toutouh Jamal
Published: May 2019

Enhancing efficiency in Municipal Solid Waste (MSW) management is crucial for local governments, which are generally in charge of collection, since this activity explains a large proportion of their budgetary expenses. The incorporation of decision support tools can contribute to improve the MSW system, specially by reducing the required investment of funds. This article proposes a mathematical formulation, based on integer programming, to determine the location of garbage accumulation points while minimizing the expenses of the system, i.e., the installment cost of bins and the required number of visits the collection vehicle which is related with the routing cost of the collection. The model was tested in some scenarios of an important Argentinian city that stills has a door-to-door system, including instances with unsorted waste, which is the current situation of the city, and also instances with source classified waste. Although the scenarios with classified waste evidenced to be more challenging for the proposed resolution approach, a set of solutions was provided in all scenarios. These solutions can be used as a starting point for migrating from the current door-to-door system to a community bins system.
The mountaineer's method for peak detection in photoplethysmographic signals
Authors: Argüello-Prada Erick Javier
Published: May 2019

Several efforts have been made to develop algorithms for accurate peak detection in photoplethysmographic (PPG) signals. Most of those algorithms have been specifically conceived to perform under high motion artifact and baseline drift conditions. However, little has been done regarding peak detection in low-amplitude PPG signals. In an attempt to address this issue, a simple and real-time peak detection algorithm for PPG signals was proposed. In comparison with two other well-established peak detection algorithms, the proposed method was able to achieve over than 98% sensitivity and less than 3% failed detection rate, even when the amplitude of the PPG signal dropped to 0.2 V. Still, further work is needed to improve its robustness to motion artifacts.
Marginal technology based on consequential life cycle assessment. The case of Colombia
Authors: Vélez-Henao Johan Andrés , Garcia-Mazo Claudia María
Published: May 2019

Electricity data is one of the key factors in life cycle assessment (LCA). There are two different approaches to model electricity and to apply average or marginal data in LCA studies. Marginal data is used in consequential whereas average data is considered in attributional studies. The aim of this study is to provide the long-term marginal technology for electricity power generation in Colombia until 2030. This technology is one capable of responding to small changes in demand on the market and is an important issue when assessing the environmental impacts of providing electricity. Colombia is a developing country with a national power grid, which historically has been dominated by Hydropower rather than fossil fuels. This particularity makes Colombian national power grid vulnerable to climatic variations; therefore, the country needs to introduce renewable resources into the power grid. This study uses consequential life cycle assessment and data from Colombian national plans for capacity changes in the power grid. The results show that whereas marginal electricity technology would most probably be Hydropower, Wind and Solar power are projected to reach more than 1% of the national power grid by 2030.
Optimization of direct torque controlled induction motor drive by golden section method
Authors: J. Jeyashanthi , M. Santhi
Published: May 2019

A search control based energy loss minimization technique is proposed for Direct Torque Control (DTC) of three phase Induction Motor (IM) with Fuzzy Logic Controller (FLC) used in Electric Vehicles (EV). The performance parameters of the EV considered for analysis are Dynamic performance and Efficiency. DTC is used to achieve the excellent dynamic performance of the IM drive. FLC is employed to achieve accurate speed tracking and enhance the ruggedness against disturbance and uncertainties. Loss minimization using Golden section method is proposed to search optimum level of flux value for DTC of induction motor drive. This will lead to minimum core loss and enhanced efficiency of the system. The proposed work is simulated in MATLAB/SIMULINK. The simulation and experimental results are presented to validate the performance of the proposed loss minimization algorithm.
Oxidation of geraniol using niobia modified with hydrogen peroxide
Authors: Cubillos Jairo , Martínez José J. , Rojas Hugo , Marín-Astorga Norman
Published: May 2019

Nb2O5 bulk and Nb2O5 modified with H2O2 were studied in the epoxidation of geraniol at 1 bar and room temperature. The structural and morphological properties for both catalysts were very similar, indicating that the peroxo-complex species were not formed. The order of the reaction was one respect to geraniol and close to zero respect to H2O2, these values fit well with the kinetic data obtained. The geraniol epoxidation is favored by the presence of peroxo groups, which is reached using an excess of H2O2. Moreover, the availability of the geraniol to adopt the three-membered-ring transition state was found as the best form for this type of compound.
HEAT-RESISTANT COMPOSITIONS BASED ON WASTE OF ENTERPRISES OF CERAMIC INDUSTRY
Authors: KHLYSTOV A. I. , ISAEV D. I. , PODGORNAYA D. A.
Published: May 2019

The article presents various methods of synthesizing heat-resistant binders based on large-tonnage wastes of the ceramic industry. The use of expanded clay dust in the compositions of heat-resistant concrete on portlandcement allowed to increase their residual strength in the zone of critical temperatures (800-1000 ° C). It was revealed and justifi ed that the use of phosphate binders for synthesizing a binder made it possible to increase the refractoriness of the heat-resistant composition based on expanded clay dust to 1300-1350 с. As the experiments show, claydite dust in its composition contains a clay component, which ensures the plasticity of the ramming mass. It was established that samples of ramming mass on orthophosphoric acid did not require heat treatment and can be immediately removed.
MECHANISMS AND PRINCIPLES FOR THE RENOVATION OF STAGNANT AREAS OF METALLURGICAL ENTERPRISES
Authors: BLAGINYKH Elena A. , DROZHZHIN Roman A.
Published: May 2019

The industrial territories of the enterprises of ferrous metallurgy located within the city are considered, their problems at the present stage and historical and cultural signifi cance are revealed. Ways of an eff ective mechanism for improving the environmental quality of stagnant industrial areas in cities of the Siberian region are analyzed and determined. Theoretical positions and practical recommendations for the formation of strategies for the renovation of industrial areas were developed. The basic principles of the formation of public ecological spaces are formulated during the renovation of the stagnant territories of metallurgical plants located in the central regions of industrial cities. The theoretical principles of this study have been tested in the development strategy of the stagnant territory of the sludge pit of the Novokuznetsk Metallurgical Combine.
ARCHITECTURE AND MODERN STATE OF SAMARA BUILDINGS IMPLEMENTED ON SAMPLE PROJECTS
Authors: YOZHIKOVA Ekaterina Yu.
Published: May 2019

The architecture of the city of Samara of the XIX century, made on exemplary projects. The formation of the architectural environment of the city is investigated. A detailed analysis of the current state of the buildings of Samara, executed on model projects, was carried out. On the example of several monuments, their typical history of reorganizations and changes is considered. On the basis of archival research and analysis of the current state of development, features and decorative solutions of buildings are revealed. The results of the successful study of a successful past, analyze the present, which helps to prepare the basic principles of successful restoration and renovation of historic buildings.
METAL DECORATION OF BUILDINGS AND CONSTRUCTIONS ON THE TERRITORY OF THE ORENBURG PROVINCE
Authors: PONOMARENKO Elena Vladimirovna
Published: May 2019

The study was carried out at the expense of the State Program of the Russian Federation “Development of Science and Technology” for 2013-2020 in the framework of the Basic Research Plan of the Ministry of Construction of Russia and the Russian Academy of Architecture and Construction Sciences Academy of Sciences, topic 1.2.5. The article analyzes the use of metal casting in the construction of sett lements in the territory of the former Orenburg province. The appearance of the fi rst industrial sett lements of the region is considered. On the basis of the author’s on-site surveys and analysis of archival materials, samples of the use of metal parts in decorating and constructive solutions of houses, estates and churches of the Orenburg province in the XVIII-XIX centuries are revealed. The current practice of using metal in decorative decoration of residential houses for independent construction is analyzed.
ARCHITECTURAL TYPOLOGY OF HIGH-RISE HOUSING IN DUBAI
Authors: GENERALOVA Elena Mikhaylovna
Published: May 2019

The history of the development of high-rise construction in Dubai with the identifi cation of stages of varying intensity is considered . It is shown how in just a few decades it was possible to turn the desert into a modern megalopolis with a developed infrastructure and att ract thousands of foreigners here. The leading position of this unique city in the world statistics on the number of built skyscrapers and the dominance of the residential function in their structure are emphasized. The criteria of the term “the high life” for Dubai, uniqueness, trends and development prospects are analyzed. The regional specifi city of the design of high-rise residential buildings in Dubai is determined. An architectural typology of high-rise housing in Dubai has been developed with the identifi cation of the main types of integration of the residential function in the structure of high-rise buildings and complexes, as well as variants of their space-planning models.
HISTORY OF DEVELOPMENT OF SAMARA WATER PIPES
Authors: STRELKOV Alexander K. , TEPLYKH SvetlanaYu. Yur'evna , GORSHKALEV Pavel A. , TEPLYKH Anastasiya A.
Published: May 2019

The article shows the history of the development of water supply in Samara. The main stages of the development of the Samara water pipeline, starting from 1885 (creation of the fi rst water pipeline project) to 2011 (completion of construction and commissioning of an ultraviolet water treatment plant), are presented. The historical background of the creation of the Samara water pipeline project and the construction of the water supply system is given. It is told about the need for continuous expansion and improvement of the water supply system, as a result of which city water treatment plants, pumping and fi ltering stations, pumping stations of the second and third lifting, as well as new water lines were built. It is concluded that the construction of the Samara water pipeline is due to the rapidly growing number of residents and the developing industry in the city.
A 5-Week Seminar on the Biopsychosocial-Spiritual Model of Self-Care Improves Anxiety, Self-Compassion, Mindfulness, Depression, and Stress in Graduate Healthcare Students
Authors: Klawonn Amisha , Kernan Dana , Lynskey James
Published: May 2019

Graduate healthcare students can experience stress that affects their ability to perform academically and clinically, decreases empathy, and affects their well-being and clinical competence. The purpose of the current study was to determine the effects of a seminar on a yoga-inspired biopsychosocial-spiritual model of self-care on perceived levels of anxiety, self-compassion, mindfulness, depression, and stress in graduate healthcare students. We used a within-group repeated-measure design with baseline followed by intervention. The intervention was a 5-week seminar with 60-minute sessions that incorporated breathing, mindful movement, meditation, and education for self-care in five areas of a biopsychosocial-spiritual model (spiritual, physical, intellectual, energetic, and psychoemotional-social). The following outcomes measures assessed perceived changes in anxiety, self-compassion, mindfulness, depression, and stress: Beck Anxiety Inventory (BAI), Self-Compassion Scale–Short Form (SCS-SF), Freiburg Mindfulness Inventory (FMI), Kentucky Inventory of Mindfulness Skills (KIMS), Mindfulness Attention Awareness Scale (MAAS), Beck Depression Inventory (BDI), and Perceived Stress Scale (PSS). The Freidman test with Dunn's test post hoc pairwise comparisons was used for the BAI, SCS-SF, FMI, KIMS, and MAAS. A Wilcoxon signed-rank test was used for BDI and PSS. Twenty doctor of physical therapy students and one doctor of dental medicine student participated in the study. Significant improvements (all p < 0.05) were found for self-compassion, mindfulness, anxiety, depression, and stress. A 5-week seminar using a biopsychosocial-spiritual approach for self-care improved self-compassion and mindfulness and diminished anxiety, depression, and stress. Implementing programs that facilitate self-awareness and self-care may provide important benefits to future healthcare providers.
Enhancement of physical endurance in animals by means of compounds with thiourea group (review of literature)
Authors: Marysheva Vera V. , Shabanov Petr D.
Published: May 2019

At the Department of Pharmacology of the S.M. Kirov Military Medical Academy, Saint Petersburg, Russia, a number of chemical compounds with thiourea group was synthesized and studied pharmacologically for some decades. Of them gutimin and amtizol are the most known for pharmacologists. They were the first antihypoxic drugs, passed clinical investigations and were approved for reanimatology practice. Bemithyl (bemaktor, metaprot) was another known drug used in clinical urgent practice as an antihypoxic drug, it was used in earthquake in Armenia (1988), in military practice in Afghanistan etc. Antihypoxic drugs were shown to possess polyvalent pharmacological activity. This review is devoted to original compounds synthesized at the Department of Pharmacology and containing pharmacophor thiourea group in mono-, bi- and tricyclic structures. The antihypoxic activity was revealed in majority of the compounds of this row. The influence of these compounds on physical activity and endurance in different situations has been considered in the article.
Antihypoxic properties of condensed benzimidazole derivatives with antioxidant activity
Authors: Spasov Alexander A. , Kosolapov Vadim A. , Anisimova Vera A. , Zhukovskaya Olga N.
Published: May 2019

Hypoxia plays an important role in the vital activity of the organism and practically accompanies any pathology. Hypoxia and tissue ischemia in the early stages are accompanied by the activation of lipid peroxidation. Derivatives of 9-dialkylaminoethyl imidazobenzimidazole with a 3,4-dioxyphenyl substitute showed high antioxidant activity. Therefore, they have been studied for antihypoxic activity in experimental models of hypobaric, histotoxic and hemic hypoxia, as well as in animals pre-typed for resistance to hypoxia, and it was shown that new condensed benzimidazole derivatives with antioxidant activity showed a wide range of antihypoxic activity. The most pronounced protective antihypoxic properties were demonstrated by compound RU-185.
The impact of the new derivative of nicotinic acid with anti-hypoxic activity on the functions of the central nervous system
Authors: Gneushev Igor M. , Katunina Natalia P. , Novikov Vasiliy E. , Pozhilova Elena V.
Published: May 2019

The aim of the work was to study the effect of the complex compound of nicotine acid with antihypoxic activity under the code πQ-1043 on the function of the central nervous system. The experiments were performed on male mice of the SHR line. Influence of the compound on the function of the central nervous system was evaluated in the tests “open field”, conditioned-defense reflex of avoidance and corazole seizures. It was found that the compound πQ-1043 at a dose of 25 mg/kg increases emotional reactivity and reduces the coefficient of mobility of mice in the “open field” test, increases the latent time of the conditionally defensive reflex of avoidance, inhibits the development of seizures and increases the life expectancy of animals after administration of corazole. Such changes in the studied parameters indicate that the compound πQ-1043 has a depressing effect on the central nervous system function. It is assumed that the identified effect may be one of the components in the mechanism of antihypoxic action of the compound.
Physical rehabilitation and pharmacotherapy of cognitive functions and asthenic disorders in stroke patients
Authors: Firileva Janna E. , Rodichkin Pavel V. , Buznik Galina V.
Published: May 2019

The article deals with the state of cognitive functions (memory, attention and thought process) and asthenic disorders in stroke patients in the process of physical rehabilitation and pharmacotherapy. The study used conventional methods for determining the state of cognitive functions. To improve cognitive abilities in the process of physical rehabilitation in the experimental group of patients, traditional methods and special physical exercises in the form of training tasks for memory, attention and thought processes were used. In the control group of patients only traditional methods of restoration of cognitive functions were used. Both groups of patients took the same drugs to improve cognitive function and relieve symptoms of cerebrogenic asthenia, using classic nootropic drugs (Pyracetam, Phenotropil, Vinpotropil), peptide drugs (Cortexin, Cerebrolysin, Noopept, Semax), antidepressants and tranquilizers (benzodiazepines and non-benzodiazepine). It is determined that the most important indicator of memory quality is short-term memory. In the experimental group in the process of physical rehabilitation revealed an improvement in this memory in 50% of patients, the deterioration of this indicator in 34% of persons, and 16% memory remained at the same level. Short-term memory indices in post-stroke patients of the control group are lower and correspond to: improvement – in 35%, deterioration – in 40%, remained at the same level in 25% of patients. Since the rate of short-term memory is 7 ± 2 units of information, the study showed that in all patients after a stroke, the indicators of storing information in short-term memory have become normal. The study of attention stability revealed that in the control group of patients it is worse than in the experimental group, and that the stability of attention does not depend on the experience of the post-stroke state. Patients with 3 years of post-stroke experience show the same results as patients with 6-month stroke. The study of inductive thinking showed that in both groups of patients it is in good condition. As for the indicators of practical mathematical thinking, 83% of the participants coped with the task in the experimental group, and 17% failed. In the control group, 57% of patients coped with this task, and 43% failed. Only 50% of the patients in the experimental group and 42% of the control group coped with a more difficult task in this type of thinking. The same results were obtained in persons without stroke. This shows that the more difficult tasks of identifying this type of thinking are difficult for people after a stroke. It can be concluded that the mental processes of a person after a stroke are in optimal condition.
Cardiac rehabilitation today: opportunities and challenges
Authors: Protasov Evgenij А. , Velikanov Arseniy A.
Published: May 2019

Russian health care faces the task of reducing mortality and disability of patients with coronary heart disease. This problem could be solved with outpatient rehabilitation and secondary prevention. Despite of numerous evidences of their effectiveness there is no publicly available system for the management of patients with the addition of non-drug treatments to drug therapy in our country. This is due to the lack of material and technical base, a sufficient number of specialists, underestimation of this method by the physicians and low patients’ motivation. A special problem is the patient behavior itself, which can be described as “irrational”.
New guidelines on cardiovascular diseases and the results of clinical research: Review of European Cardiology Congress 2018
Authors: Frolova Elena V.
Published: May 2019

In this review the information is presented about new clinical guidelines on arterial hypertension, syncope guidelines, about screening of atrial fibrillation and antithrombotic and anticoagulants usage according clinical trials data. Attention is payed to digital technologies in health care sector. This information is based on data of European Cardiology Congress 2018.
Arquivo e memória: movimentos da escrita de Samuel Rawet a partir da transcrição do poema “A eclusa”, de Paul Celan
Authors: Bruel Bianca Iung , Bines Rosana Kohl
Published: May 2019

Este artigo investiga possíveis demonstrações de um modus operandi da escrita de Samuel Rawet a partir da análise das relações entre anotações do autor e a composição de seu texto literário. O estudo apresenta, de forma inédita, uma seleção de itens do arquivo de Rawet, recentemente doados ao Arquivo Museu de Literatura Brasileira da Fundação Casa de Rui Barbosa, localizado no Rio de Janeiro. Nosso propósito é refletir e considerar algumas das estratégias de escrita e de atividades literárias do autor. A transcrição do poema “A eclusa”, de Paul Celan, feita à mão por Rawet em papel avulso, e sua possível conexão com a produção de Kadish: Oração pelos vivos das Olimpíadas de Munique, assim como suas anotações deixadas em caderneta relatando percepções sobre memória, formam o corpus dessa investigação.
O caso dos descendentes de Lot
Authors: Klevanskis Juliano
Published: May 2019

O caso dos descendentes de Lot
Ensaios contra a inércia da repetição e da neutralidade diante da Shoah
Authors: Rosenbaum Paulo
Published: May 2019

Resenha a: NASCIMENTO, Lyslei. Despertar para a noite e outros ensaios. Belo Horizonte: Quixote-Do, 2018. 178p.
Bat Israel (Uma filha de Israel)
Authors: Steinberg Yaacov
Published: May 2019

Tradução: Gabriel Steinberg
A gênese de O Diário de Anne Frank – um legado para a humanidade
Authors: Cornelsen Elcio Loureiro
Published: May 2019

Nossa contribuição visa a uma breve apresentação da gênese de O diário de Anne Frank, uma das obras mais lidas desde sua primeira publicação, no final dos anos 1940. Além de enfocarmos as estações da vida de Anne Frank e de sua família, desde a fuga da Alemanha em 1933, a vida na Holanda e o confinamento em um esconderijo a partir de 1942, quando Amsterdã foi invadida por tropas do exército alemão, até a prisão e a deportação para os campos de concentração e de extermínio nazistas em agosto de 1944, discorreremos também sobre as especificidades das quatro versões do diário, bem como sobre algumas estratégias adotadas por Anne Frank para produzir seu relato íntimo sobre as agruras do confinamento e de um mundo que desmoronava a sua volta.
Female Patients and Informed Consent: Oman’s cultural background
Authors: Al Balushi Amal A.
Published: May 2019

Female patients in Oman face a certain amount of pressure from their families when making high-stakes decisions regarding personal healthcare. In fact, some women waive their right to make decisions, typically giving that responsibility to their husbands or fathers. This article highlights the need to empower females in decision-making when it comes to their own well-being. Moreover, informed consent should not be signed by anyone but the patient herself if the patient is deemed competent by a medical professional. Keywords: Informed Consent; Female; Decision Making; Clinical Competence; Medical Ethics; Patient Rights; Oman.
Randomised Trial of Oral Misoprostol Versus Manual Vacuum Aspiration for the Treatment of Incomplete Abortion at a Nigerian Tertiary Hospital
Authors: Ibiyemi Kehinde F. , Ijaiya Munir'deen A. , Adesina Kikelomo T.
Published: May 2019

Objectives: This study aimed to compare the efficacy of oral misoprostol with manual vacuum aspiration (MVA) in first trimester incomplete abortions. Methods: This randomised controlled trial study was conducted at the University of Ilorin Teaching Hospital, Ilorin, Nigeria between April 2014 and November 2015. Pregnant women who presented with clinical features of incomplete abortion at a gestational age of 13 weeks or less were included. Patients who had profuse vaginal bleeding, an intrauterine device in situ, signs of pelvic infections or who were younger than 18 years old and had no accompanying adults to give informed consent were excluded. A total of 200 participants were randomly and equally allocated to either the MVA or misoprostol treatment group. The treatment group were given 600 μg of misoprostol orally. The primary outcome measure was complete uterine evacuation, while secondary outcome measures included the need for additional surgical evacuation for failed treatment, adverse effects/complications, acceptability of and satisfaction with the treatment. Results: Both misoprostol and MVA had high complete evacuation rates, yet MVA was significantly higher (99% versus 83%, relative risk [RR]: 0.84, confidence interval [CI]: 0.766–0.918; P <0.001). Significantly more women in the misoprostol group required additional MVA for failed treatment than in the MVA treatment group (17% versus 1%, RR: 16.67, CI: 2.260–12.279; P <0.001). No significant difference was found between the misoprostol and MVA treatment groups in terms of satisfaction (92.7% versus 89.8%, RR: 1.04, CI: 0.946–1.127; P = 0.473). Conclusion: Treatments with misoprostol and MVA had high complete uterine evacuation rates, as well as high rates of acceptability and satisfaction. However, MVA had a significantly higher complete evacuation rate than misoprostol.Keywords: Misoprostol; Abortion Techniques; First Trimester; Incomplete Abortion; Nigeria.
Authors’ Selection of Target Journals and Their Attitudes to Emerging Journals: A survey from two developing regions
Authors: Beshyah Salem A.
Published: May 2019

Objectives: This study aimed to assess the factors that influence authors' decision when choosing a journal for publication and to assess authors' attitudes and practices regarding emerging journals. Methods:cross-sectional questionnaire-based study was conducted between April and July 2017 at Dubai Medical College, Dubai, United Arab Emirates, on a convenience sample of 2,764 healthcare professionals. Results: A total of 250 responses were received (response rate: 9%) and 152 valid respondents were included in this study (5.6%), of which the majority were male (61.2%) and aged 41–60 years (68%) from the Middle East and Africa. Most respondents (88.8%) had medical and/or dental qualifications and the majority were in senior clinical (55%) and academic (71.5%) positions. More than half of the respondents (62.5%) had published at least one article in the previous five years. Results showed that journal impact factor (JIF), indexation status, free submission and being international were important among respondents. Based on the respondents that shared their encounters with emerging journals (n = 114), 62 respondents (54.4%) regularly read certain emerging journals, 51 (44.7%) had been a peer-reviewer, 48 (42.1%) had cited content from an emerging journal at least once and 45 (39.5%) had published in emerging journals. Only 18 respondents (14.2%) were not convinced with the need for emerging journals and believed that all researchers should compete for publication in the same international journals. Conclusion: Selection of target journals is driven mainly by JIF, indexation status, free submission and a journal’s international status. A diverse range of opinions and attitudes regarding emerging journals were observed in this study. Keywords: Journal Impact Factor; Open Access Publishing; Editorial Policy; Peer Review; Indexing; Publications; Attitude; United Arab Emirates.
Obstetrics and Gynaecology as a Future Career for Medical Graduates in Oman: Factors that attract and discourage graduates
Authors: Al Salehi Asma , Al Dughaishi Tamima , Rizvi Gauhar , Gowri Vaidyanathan
Published: May 2019

Objectives: Obstetrics and gynaecology (OBGYN) is a major speciality in the medical field that is often demanding yet rewarding; however, OBGYN receives the least number of applicants in Oman. This study aimed to determine the factors that influence graduates in choosing OBGYN as their speciality. Methods: This cross-sectional questionnaire-based study was conducted from February to March 2017 at Sultan Qaboos University Hospital, Royal Hospital, Khoula Hospital and Al Nahdha Hospital, Muscat, Oman. The questionnaire was distributed to 150 Omani medical graduates (interns and post-intern doctors). Results: A total of 145 Omani graduates took part in the study (response rate: 96.7%) and the participants’ average age was 26 years. Family medicine ranked as the first choice followed by paediatrics and emergency medicine. OBGYN was the first choice for eight female graduates. The top factors attracting male graduates to the OBGYN speciality were its surgical opportunities (80.6%), intellectual content (77.4%), faculty interactions and the opportunity to care for a healthy population (54.8% each); however, the top factors attracting females were the intellectual content (88.6%), patients’ desire for female physicians (85.1%), the opportunity to care for a healthy population (76.3%) and cultural expectations (69.5%). The most discouraging factors for male graduates were cultural expectations (100%), the patients’ desire for a female physician (93.5%) and the level of stress (71%), while the discouraging factors for female graduates were the level of stress (82.5%), time demands (78.1%), night duties and the length of the residency (71.9% each). Conclusion: Most of the factors that discourage female graduates from choosing OBGYN are to some extent modifiable. These changes should be considered to encourage the selection of OBGYN as a career by medical students.Keywords: Career Choice; Obstetrics and Gynecology Department, Hospital; Internship and Residency; Medical Student; Oman.
Branchial Cyst: A Case Report
Authors: Borse Hemantkumar Gopal , Vaswani Usha
Published: May 2019

Branchial cyst is a rare developmental disorder which is diagnosed rarely. Remnants of Branchial are present at birth but may become clinically significant later in life. We report a case of 14-year-old male patient with an asymptomatic branchial cyst over lateral side of neck. These cyst originate from remnants of branchial arches or branchial pouches. The definitive treatment of is complete surgical excision of the cyst. Complete surgical excision prevents recurrence or other complications.