bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of best practice advisory on the administration of contraindicated medications to hospitalized patients with Parkinson’s disease and related disorders
Authors: Chunga Natalia , Amodeo Katherine , Braun Melanie , Valdovinos Blanca Y. , Richard Irene H.
Published: December 2023

Objective

To determine the effect of a Best Practice Advisory (BPA) on the ordering and administration of contraindicated dopamine blocking agents (DBA) to hospitalized patients with Parkinson’s disease (PD) and related disorders.

Background

Patients with PD are more likely to require hospitalization and are at increased risk of complications. Administration of contraindicated DBA contributes to worsened outcomes in this patient population. Electronic medical record (EMR) warnings (also referred to as BPA) have been proposed as a way to prevent the administration of contraindicated medications.

Methods

A BPA was launched in January 2020 within the University of Rochester EMR system, which alerts the provider when a contraindicated DBA is ordered in hospitalized patients with PD and related disorders. Patients with PD and related disorders hospitalized at two hospitals affiliated to the University of Rochester during a time period before (t1: 1/1/2019–1/1/2020) and after (t2: 1/8/2020–1/8/2021) the implementation of the BPA were included in this study. Epic SliderDicer was used to collect the data from the University of Rochester EMR. The number of patients who had contraindicated DBA orders and administrations in both time periods, and the number of patients who had the BPA triggered during t2 were obtained. We compared the results before and after the implementation of the BPA.

Results

306 patients with PD and related disorders were hospitalized during t1 and 273 during t2. There was significantly less percentage of patients who had contraindicated DBA orders (41.5% in t1 vs. 17.6% in t2) and patients who had contraindicated DBA administrations (16% in t1 vs. 8.8% in t2) during t2 (p < 0.05 for both comparisons). There was no significant difference between the percentage of patients who had contraindicated DBA orders in t1 and patients with attempted orders (BPA triggered) in t2 (p = 0.27).

Conclusion

The results of this study increase the evidence of the potential benefit of EMR warnings for the optimization of inpatient medication management in patients with PD and related disorders. In particular, our results suggest that EMR warnings help reduce the administration of contraindicated medications, which is a known contributing factor for hospital complications in this patient population.
A first ecological coherent assessment of eutrophication across the North-East Atlantic waters (2015–2020)
Authors: Devlin Michelle J. , Prins Theo C. , Enserink Lisette , Leujak Wera , Heyden Birgit , Axe Philip G. , Ruiter Hans , Blauw Anouk , Bresnan Eileen , Collingridge Kate , Devreker David , Fernand Liam , Gómez Jakobsen Francisco J. , Graves Carolyn , Lefebvre Alain , Lenhart Hermann , Markager Stiig , Nogueira Marta , O'Donnell Garvan , Parner Hjalte , Skarbøvik Eva , Skogen Morten D. , Sonesten Lars , Van Leeuwen Sonja M. , Wilkes Robert , Dening Eleanor , Iglesias-Campos Alejandro
Published: December 2023

This paper presents the outcomes of the fourth application of the Common Procedure for the Identification of the Eutrophication Status of the OSPAR Maritime Area (the “Common Procedure”), conducted for the period 2015–2020 for the North East Atlantic. Previously, OSPAR has assessed eutrophication based on national assessment areas and disparate approaches lacking a transparent and comparable basis. A more harmonized approach has now been achieved through development of ecologically relevant assessment areas defined by oceanographic criteria rather than international boundaries, allowing for consistent assessments across exclusive economic zones and acknowledging that eutrophication is a transboundary problem. Thresholds that were specific for those harmonized assessment areas and eutrophication parameters have been derived primarily from an ensemble modeling approach to determine pre-eutrophic conditions. Common assessment areas and harmonized thresholds have enabled, for the first time, an objective and comparable assessment of the eutrophication status of the whole OSPAR Maritime Area. This establishes a level playing field for managing eutrophication and a solid basis for deriving OSPAR nutrient reduction targets as a prerequisite for targeted and successful regional eutrophication management. This assessment shows that eutrophication problem areas persist, in particular along the continental coasts from France to Denmark/Sweden and in the Greater North Sea and the Bay of Biscay and Iberian coast. The main areas affected by eutrophication are the plumes and adjacent coastal areas in the Greater North Sea and Bay of Biscay/Iberian Coast, with riverine nutrient inputs remaining the major source of nutrient pollution. Approximately 6% (152,904 km2) of the OSPAR Maritime Area is eutrophic, with the impacted area supporting many important ecosystem services. Fifty-eight percent of river plume areas (eight assessment areas out of 14), 22% (five of 27) of the coastal areas and 10% (three of 17) of the shelf areas were classified as problem areas. Application of the current assessment process to historical data from the previous three OSPAR assessment periods shows a gradual improvement since 2000. However, the OSPAR 2010 objective “to combat eutrophication, with the ultimate aim of achieving and maintaining a healthy marine environment where anthropogenic eutrophication does not occur” has not yet been fully achieved. Further measures to reduce nutrient loads are needed to ensure long-term sustainability of our coastal waters.
Impact of statin use on breast cancer recurrence and mortality before and after diagnosis: a systematic review and meta-analysis
Authors: Jia Xiaolin , Lu Ye , Xu Zili , Mu Qingqing
Published: December 2023

Objective

Breast cancer is one of the most common causes of death among women. Statins, typically used for cholesterol management, have been hypothesized to reduce recurrence and mortality rates in breast cancer. However, this association remains a subject of debate. This study evaluates the potential impact of statins on breast cancer recurrence and mortality.

Methods

A comprehensive search was conducted in the PubMed, EMBASE, and Cochrane databases for articles published up to June 2023. These articles examined the effect of statins on breast cancer recurrence and mortality both before and after diagnosis. The analysis was performed using random-effects models, calculating pooled hazard ratios (HR) and their 95% confidence intervals (CI).

Results

A total of 31 cohort studies, involving 261,834 female breast cancer patients, were included in this analysis. It was found that statin use prior to diagnosis was associated with a decrease in overall mortality (HR, 0.8; 95% CI, 0.69–0.93; I2 = 77.6%; P = 0.001) and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.87; I2 = 72.7%; P = 0.005). Additionally, statin use after diagnosis was observed to reduce the recurrence of breast cancer (HR, 0.71; 95% CI, 0.61–0.82; I2 = 60%; P = 0.003), overall mortality (HR, 0.81; 95% CI, 0.70–0.92; I2 = 80.7%; P < 0.001), and breast cancer-specific mortality (HR, 0.76; 95% CI, 0.67–0.86; I2 = 74.5%; P < 0.001).

Conclusions

The findings of this study indicate that statin usage, both before and after breast cancer diagnosis, may be associated with reduced risks of overall and breast cancer-specific mortality, as well as lower recurrence rates.
Safety and feasibility of laparoscopic radical resection for bismuth types III and IV hilar cholangiocarcinoma: a single-center experience from China
Authors: Wang Jianjun , Xia Yang , Cao Yuan , Zeng Xintao , Luo Hua , Cai Xianfu , Shi Mingsong , Luo Huiwen , Wang Decai
Published: December 2023

Background

Surgery represents the only cure for hilar cholangiocarcinoma (HC). However, laparoscopic radical resection remains technically challenging owing to the complex anatomy and reconstruction required during surgery. Therefore, reports on laparoscopic surgery (LS) for HC, especially for types III and IV, are limited. This study aimed to evaluate the safety and feasibility of laparoscopic radical surgery for Bismuth types III and IV HC.

Methods

The data of 16 patients who underwent LS and 9 who underwent open surgery (OS) for Bismuth types III and IV HC at Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, between December 2017 and January 2022 were analyzed. Basic patient information, Bismuth–Corlette type, AJCC staging, postoperative complications, pathological findings, and follow-up results were evaluated.

Results

Sixteen patients underwent LS and 9 underwent OS for HC. According to the preoperative imaging data, there were four cases of Bismuth type IIIa, eight of type IIIb, and four of type IV in the LS group and two of type IIIa, four of type IIIb, and three of type IV in the OS group (P>0.05). There were no significant differences in age, sex, ASA score, comorbidity, preoperative percutaneous transhepatic biliary drainage rate, history of abdominal surgery, or preoperative laboratory tests between the two groups (P>0.05). Although the mean operative time and mean intraoperative blood loss were higher in the LS group than in OS group, the differences were not statistically significant (P=0.121 and P=0.115, respectively). Four patients (25%) in the LS group and two (22.2%) in the OS group experienced postoperative complications (P>0.05). No significant differences were observed in other surgical outcomes and pathologic findings between the two groups. Regarding the tumor recurrence rate, there was no difference between the groups (P>0.05) during the follow-up period (23.9 ± 13.3 months vs. 17.8 ± 12.3 months, P=0.240).

Conclusion

Laparoscopic radical resection of Bismuth types III and IV HC remains challenging, and extremely delicate surgical skills are required when performing extended hemihepatectomy followed by complex bilioenteric reconstructions. However, this procedure is generally safe and feasible for hepatobiliary surgeons with extensive laparoscopy experience.
Mechanical asymmetries remain low-to-moderate during 30 min of self-paced treadmill running
Authors: Mtibaa Khouloud , Zarrouk Nidhal , Ryu Joong Hyun , Racinais Sébastien , Girard Olivier
Published: December 2023

Introduction: We characterized the magnitude and range of gait asymmetry during self-paced treadmill running.

Methods: On an instrumented treadmill, twelve trained runners (11 males, 1 female) completed a 30-min self-paced run, during which participants were instructed to cover the most distance possible. Ground reaction force recordings at a constant velocity corresponding to 70% of their maximal aerobic velocity (13.3 ± 0.8 km.h−1) allowed for the measurement of running kinetics and kinematics, as well as the calculation of spring-mass characteristics at the beginning, middle, and end of the run (minutes 1, 14, and 29, respectively). Group mean asymmetry scores were assessed using the “symmetry angle” (SA) formulae, where scores of 0% and 100% represent perfect symmetry and perfect asymmetry, respectively.

Results: There was no time effect on SA scores for any of the 13 biomechanical variables (p ≥ 0.128). Mean SA scores were <2.5% for contact time (0.8% ± 0.7%), flight time (1.4% ± 0.6%), step frequency (0.7% ± 0.3%), duty factor (0.7% ± 0.3%), duration of braking (1.3% ± 0.7%) and push-off phases (0.9% ± 0.8%), as well as peak braking (2.3% ± 1.3%) and push-off forces (1.4% ± 0.9%). Mean SA scores were ≥2.5% for peak vertical loading rate (3.1% ± 1.7%), mean vertical loading rate (3.4% ± 2.1%), peak vertical forces (2.9% ± 2.2%), as well as vertical stiffness (5.2% ± 3.5%) and leg stiffness (2.5% ± 1.5%).

Conclusion: Throughout a 30-min running time trial, there were consistently low-to-moderate mechanical asymmetries for spatiotemporal variables, kinetics, and spring-mass model characteristics. This suggests that trained runners maintained relatively even strides during the self-paced treadmill run, with lower extremities behaving similarly when controlling for velocity.
Tailored lighting intervention (TLI) for improving sleep-wake cycles in older adults living with dementia
Authors: Figueiro Mariana G. , Pedler David , Plitnick Barbara , Zecena Erick , Leahy Sophie
Published: December 2023

Introduction: Sleep disturbance is a hallmark of Alzheimer’s disease and related dementias, and caregiver stress caused by patients’ nighttime wandering, injuries, and agitation are frequently at the root of decisions to move them to assisted living facilities, where typically dim institutional lighting can further exacerbate their sleep problems. This study explored the effects of a circadian-effective lighting intervention on actigraphic sleep measures and subjective assessments of sleep disturbance, depression, and sleep-disturbed behaviors.

Methods: Fourteen older adult (≥60 years) participants (11 females, mean age = 84.1 [SD 8.9]), all diagnosed with moderate to severe dementia and sleep disturbance, were recruited from 3 assisted living and memory care facilities. Following a crossover, placebo-controlled design, 3 different lighting modes were used to deliver high levels of circadian stimulus to the participants’ eyes for two 8-week intervention periods in a counter balanced order with a 4-week washout between the study’s 2 conditions (dim light control vs. active intervention). Actigraphy and questionnaire data were collected over 7-day assessment periods that preceded (baseline weeks 1 and 9) and concluded (post-intervention week 9 and 22) the intervention periods. Actigraphic outcomes included sleep duration, sleep time, sleep efficiency, sleep start time, and sleep end time. Subjective assessments included the Cornell Scale for Depression in Dementia (CSDD), Pittsburgh Sleep Quality Index (PSQI), and Sleep Disorders Inventory (SDI) instruments.

Results: Under the active condition, sleep duration significantly (p = 0.018) increased and sleep start time significantly (p = 0.012) advanced after the intervention compared to baseline. Also under the active condition, PSQI (p = 0.012), CSDD (p = 0.007), Sleep Disorders Inventory frequency (p = 0.015), and SDI severity (p = 0.015) scores were significantly lower after the intervention compared to baseline.

Discussion: This study demonstrates that a circadian-effective lighting intervention delivering bright days and dark nights improves measures of sleep and mood in dementia patients living in controlled environments.
Unraveling the role of galectin-3 in cardiac pathology and physiology
Authors: Seropian Ignacio M. , Cassaglia Pablo , Miksztowicz Verónica , González Germán E.
Published: December 2023

Galectin-3 (Gal-3) is a carbohydrate-binding protein with multiple functions. Gal-3 regulates cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions. It is implicated in the development and progression of cardiovascular disease, and its expression is increased in patients with heart failure. In atherosclerosis, Gal-3 promotes monocyte recruitment to the arterial wall boosting inflammation and atheroma. In acute myocardial infarction (AMI), the expression of Gal-3 increases in infarcted and remote zones from the beginning of AMI, and plays a critical role in macrophage infiltration, differentiation to M1 phenotype, inflammation and interstitial fibrosis through collagen synthesis. Genetic deficiency of Gal-3 delays wound healing, impairs cardiac remodeling and function after AMI. On the contrary, Gal-3 deficiency shows opposite results with improved remodeling and function in other cardiomyopathies and in hypertension. Pharmacologic inhibition with non-selective inhibitors is also protective in cardiac disease. Finally, we recently showed that Gal-3 participates in normal aging. However, genetic absence of Gal-3 in aged mice exacerbates pathological hypertrophy and increases fibrosis, as opposed to reduced fibrosis shown in cardiac disease. Despite some gaps in understanding its precise mechanisms of action, Gal-3 represents a potential therapeutic target for the treatment of cardiovascular diseases and the management of cardiac aging. In this review, we summarize the current knowledge regarding the role of Gal-3 in the pathophysiology of heart failure, atherosclerosis, hypertension, myocarditis, and ischemic heart disease. Furthermore, we describe the physiological role of Gal-3 in cardiac aging.
Prediction of tannin content and quality parameters in astringent persimmons from visible and near-infrared spectroscopy
Authors: Baek Min Woo , Choi Han Ryul , Hwang In Geun , Tilahun Shimeles , Jeong Cheon Soon
Published: December 2023

Introduction

Tannin content and postharvest quality characteristics of persimmon fruit are often determined by the destructive analysis that consumes time, does not allow the acquisition of data from the same fruit continuously, and requires expensive high-performance equipment. This research was done to investigate the potential for non-destructive estimation of astringency and quality parameters in persimmon fruit based on visible/near-infrared (VNIR) spectra.

Methods

VNIR spectra readings, the reference tannin content, and quality parameters were measured from fruits of “Cheongdo-Bansi” and “Daebong” persimmon cultivars at harvest and throughout the ripening/deastringency period. The spectra readings from half of the total fruit were utilized for the calibration set, while the other half readings were used for the prediction set. To develop models correlating the spectra data to the measured reference parameters data, the partial least square regression (PLSR) method was utilized.

Results and discussion

In the case of ‘Daebong’, the coefficients of determination (R2) between VNIR spectra and the actual measured values of TSS, firmness, simple sugars, and tannin content were (0.95, 0.94, 0.96, and 0.96) and (0.93, 0.89, 0.96, and 0.93), for the calibration and prediction sets, respectively. Similarly, the R2-values of (0.86, 0.93, 0.79, and 0.81) and (0.83, 0.91, 0.75, and 0.75) were recorded in ‘Cheongdo-Bansi’ for the calibration and prediction sets, respectively. Additionally, the acquired data were divided into two sets in a 3:1 ratio to develop predictive models and to validate the models in multiple regressions. PLSR models were developed in multiple regression to estimate the tannin content of both cultivars from firmness and simple sugars with R2-values of 0.83 and 0.79 in ‘Cheongdo-Bansi’ for the calibration and prediction sets, respectively, whereas, R2-values of 0.80 and 0.84 were recorded in ‘Daebong’ for the calibration and prediction sets, respectively. The overall findings of this study showed the possibility of using VNIR spectra for the prediction of postharvest quality and tannin contents from intact persimmon fruit with quick, chemical-free, and low-cost assessment methods. Also, the multiple regression using physicochemical parameters could fairly predict the tannin content in persimmon fruit though destructively but save time and low-cost.
Evaluating an inclusive program for promoting equal-status participation in classrooms with high sociolinguistic diversity: diversity valuation and multilingual cooperative activities
Authors: Buchs Céline , Margas Nicolas , Hascoët Marine
Published: December 2023

Introduction

The inclusion of students with diverse heritage languages is an emerging issue in all OECD countries due to the global rise in international migration. With regard to their large cultural and linguistic heterogeneity, primary school classes in the French-speaking region of Switzerland are extraordinary grounds to develop inclusive teaching in context of high diversity. This research-action aims to enhance students’ status among their peers and promote equal-status participation in academic activities in such classes. The research perspective focuses on valuing diversity within classes and emphasizing students’ linguistic competence through cooperative activities.

Methods

The tested inclusive program places value on linguistic diversity and proposes multilingual cooperative activities that involve students’ family languages and require the contributions of all students. The research was conducted over the course of a school year, involving 3rd-4th grade students. It compared the evolution students’ status among peers (being chosen as a groupmate for play and work) from the beginning to the end of the school year in four classes with the inclusive program (N = 77) and four control classes without the inclusive program (N = 62).

Results

The results indicated expected changes in status: status increased in classes with the inclusive program, while it decreased in classes without the program. Moreover, the intervention specifically supported the status of vulnerable pupils. In classes with the inclusive program, students with initially low status experienced the greatest improvement, whereas in control classes, there was no correlation between initial status and changes in status. At the beginning of the school year, across all classes, students with low status participated passively, experiencing higher levels of exclusion and displaying more discrete behavior, highlighting potential initial status-problems issues. This pattern persisted in control classes without the inclusive program, where low-status students were more likely to remain passive, while initially high- status students were more likely to become leaders. In contrast, with the inclusive program, the relationship between status and participation diminished by the end of the year.

Discussion

These findings suggest that the inclusive program contributed to reducing status-related problems and promoting more equal-status participation.
A longitudinal study of the association between depression, anxiety and stress symptoms of university students in Serbia with excessive social media use before and during COVID-19 pandemic
Authors: Višnjić Aleksandar , Kök Kıvanç , Višnjić Jovana , Jovanović Tamara , Marković Roberta
Published: December 2023

Background

Besides the well known good side of social media, it cannot be denied some of its negative effects. This two-phase study aimed to find out whether the usage of social media during the COVID-19 pandemic showed some significant association with depression and anxiety symptoms, and levels of stress.

Methods

The study was based on the survey of 1,476 randomly selected students at the initial phase (December 2019 to February 2020), and 1,400 students of the same cohort at the follow up phase (December 2021–February 2022). The collected data included socio-demographics, social media usage aspects, and the ones concerning levels of depression, stress and anxiety symptoms. Standardized questionnaires – the Bergen Social Media Addiction Scale (BSMAS) was applied to measure the levels of social media addiction, and the Depression Anxiety Stress Scale (DASS 42) was administered to evaluate the symptoms of depression, anxiety and stress.

Results

The comparison of responses regarding the six components of online social media addiction, which constitute the BSMAS, between the two phases of the study showed significant difference (p < 0.01) in favor of the follow up phase in the raised scores of all but one component. The probable severe or extremely severe symptoms of depression, anxiety, and stress were notably enhanced during the peak of pandemic, and all three of them were positively correlated with all 6 BSMAS components (p < 0.01). The results also indicate that students, who consumed alcohol beverages and psychoactive substances more frequently in the pandemic, exhibited more noticeable symptoms of depression (p < 0.01, for both associations). Higher levels of anxiety symptoms in students were found to be associated with longer sleep during the night (p < 0.01), increased alcoholic beverages consumption (p < 0.01). Stress levels had the strongest correlations with consuming alcoholic beverages during the pandemic (r = 0.16, p < 0.01).

Conclusion

The comparison between two phases of this follow-up study revealed significant changes in the Internet usage characteristics, which may have had an essential influence on the investigated symptoms of depression, anxiety, and stress. However, other factors that may have influenced student’s mental health during the COVID-19 pandemic should also be considered.
What a mix! Volatile organic compounds and worker exposure in small business beauty salons in Tucson, Arizona
Authors: Ramírez Denise Moreno , Gutenkunst Shannon , Lothrop Nathan , Quijada Carolina , Chaires Marvin , Cortez Imelda , Sandoval Flor , Camargo Fernanda J. , Gallardo Emma V. , Torabzadeh Elmira , Wagoner Rietta , Lopez-Galvez Nicolas , Ingram Maia , Billheimer Dean , Wolf Ann Marie , Beamer Paloma I.
Published: December 2023

Introduction

Small business beauty salons have volatile organic compounds (VOCs) in their workplace air. VOCs are present as ingredients in beauty or hair products. They may also form because of chemical reactions, where thermal-styling elements accelerate the volatilization of these compounds. Uncertainties remain about the relationship between air pollutant concentrations and the variety of beauty salon activities in a work shift. Investigating these associations can help determine high-risk services, associated products, and at-risk workers.

Methods

In this exploratory study, female community health workers recruited beauty salons from target zip codes in predominately Latino neighborhoods, including primarily Spanish-speaking small businesses. We collected salon chemical inventories, business characteristics, and participant activity logs to understand how chemicals and activities influence the total and specific VOC concentrations. We sampled personal total VOCs and specific VOCs from the same shop during the participant work shift. We also measured personal total VOCs for four work shifts per shop.

Results

A linear mixed effects model of log VOCs on the fixed effect of activity and the random effects of salon and shift within the salon showed that the variance between salons explains over half (55%) of the total variance and is 4.1 times bigger than for shifts within salons. Summa canisters detected 31 specific VOCs, and hazard scores ranged between 0 and 4.3. 2-Propanol (isopropyl alcohol) was the only VOC detected in all shifts of all salons.

Discussion

In this study, differences in VOC measurements were primarily between salons. These differences may result from differences in ventilation, services rendered, and product lines applied.
Association between perceived stress and history of intimate partner violence throughout life and during the COVID-19 pandemic
Authors: da Costa Siqueira Loys Lene , de Melo Batista Karla , Marabotti Costa Leite Franciéle
Published: December 2023

Introduction

Intimate Partner Violence (IPV) is a significant public health issue, characterized by being a highly stressful experience for its victims. The relationship between IPV and stress creates a harmful cycle with broad health implications, affecting individuals and society at large. Despite its significance, there's a noticeable lack of research on this topic, especially regarding IPV throughout one's life and during the pandemic.

Objective

To verify the association between perceived stress and the history of intimate partner violence throughout life and during the COVID-19 pandemic.

Materials and methods

Analytical cross-sectional epidemiological study with a sample of 1,086 women. Sociodemographic information and violence history, assessed using the World Health Organization Violence Against Women (WHO VAW STUDY), along with perceived stress measured by the short version of the Perceived Stress Scale (PSS), were collected. The sampling process unfolded through multiple stages. For bivariate analyses, the t-test and ANOVA were performed, whereas for multivariate analyses simple and multiple linear regression were performed. The software Stata® version 15.1 and R® were used.

Results

Women who reported having suffered intimate partner violence throughout their lives had higher means of stress (18.49), with an average increase of 4 points without adjustments and 3.5 points after adjustments for sociodemographic variables. Similarly, during the COVID-19 pandemic (19.01), stress increased by an average of 3.3 points, which was reduced to 2.8 points after adjustments.

Conclusion

The results indicate an association between intimate partner violence and an increase in women's perceived stress, both throughout life and during the pandemic. The importance of preventive approaches, promoting gender equality and preventing IPV from the early stages of life is highlighted. In addition, they underscore the urgency of evidence-based interventions of a comprehensive nature to deal with this complex issue in a careful and effective manner. The cross-sectional nature of this study limits the inference of causality, and an additional limitation is acknowledged concerning information bias. This bias relates to the multifaceted issues surrounding the concept of violence, potentially influencing the accuracy of participants' information and complicating the measurement of violence.
E-cigarette exposure causes early pro-atherogenic changes in an inducible murine model of atherosclerosis
Authors: Alakhtar Bayan , Guilbert Cynthia , Subramaniam Nivetha , Caruana Vincenza , Makhani Kiran , Baglole Carolyn J. , Mann Koren K.
Published: December 2023

Introduction: Evidence suggests that e-cigarette use (vaping) increases cardiovascular disease risk, but decades are needed before people who vape would develop pathology. Thus, murine models of atherosclerosis can be utilized as tools to understand disease susceptibility, risk and pathogenesis. Moreover, there is a poor understanding of how risk factors for atherosclerosis (i.e., hyperlipidemia, high-fat diet) intersect with vaping to promote disease risk. Herein, we evaluated whether there was early evidence of atherosclerosis in an inducible hyperlipidemic mouse exposed to aerosol from commercial pod-style devices and e-liquid.

Methods: Mice were injected with adeno-associated virus containing the human protein convertase subtilisin/kexin type 9 (PCSK9) variant to promote hyperlipidemia. These mice were fed a high-fat diet and exposed to room air or aerosol derived from JUUL pods containing polyethylene glycol/vegetable glycerin (PG/VG) or 5% nicotine with mango flavoring for 4 weeks; this timepoint was utilized to assess markers of atherosclerosis that may occur prior to the development of atherosclerotic plaques.

Results: These data show that various parameters including weight, circulating lipoprotein/glucose levels, and splenic immune cells were significantly affected by exposure to PG/VG and/or nicotine-containing aerosols.

Discussion: Not only can this mouse model be utilized for chronic vaping studies to assess the vascular pathology but these data support that vaping is not risk-free and may increase CVD outcomes later in life.
Perceived role of the veterinarian in promoting dairy cattle welfare
Authors: Brunt Michael W. , Haley Derek B. , LeBlanc Stephen J. , Kelton David F.
Published: December 2023

Improving the lives of animals in agricultural systems has primarily focused on minimizing negative experiences. Research is needed on the promotion of positive experiences (pleasure, enjoyment, play, choice, happiness) for animals and the role of veterinarians in their promotion. Our aims were to describe how Canadian bovine veterinarians and veterinary students perceive the role of a veterinarian in positive vs. negative experiences for dairy cows and to analyze the rationale provided to explain their answers. Canadian veterinary practitioners (n = 78) and veterinary students (n = 148) responded to an online cross-sectional survey and were asked, on a 7-point scale, how important the role of a veterinarian is to promote practices that influence the experience of dairy cows. We used qualitative description to analyse participants’ open-ended text responses. Practices to minimize negative experiences were most important (mean ± SE; 6.8 ± 0.03), a balance of positive and negative experiences was less important (6.4 ± 0.05), and encouragement of positive experiences scored lowest (6.0 ± 0.06), although all scored highly. Four themes were identified to explain participants’ reasoning regarding their perceived role of a veterinarian in the promotion of dairy cattle welfare, centered on: the animal, the producer, the veterinarian, and society. Participants indicated that promoting positive experiences was less important than decreasing negative experiences (5.9 ± 0.09). There were four themes identified to explain participants’ reasoning regarding the relative importance of promotion of positive experiences versus decreasing negative experiences which centered on: frameworks to compare positive and negative experiences, impacts on the animal, the participant’s view of their role, and the practicality of implementation. These results indicate modest differences in valuing avoidance of negative vs. promotion of positive welfare. There were no differences in the quantitative analyses between veterinarians and veterinary students. We conclude that veterinarians are favorably disposed to positive aspects of welfare for dairy cows but may be more focussed on avoidance of negative aspects of welfare.
Research on the Anti-Swing Control Methods of Dual-Arm Wheeled Inspection Robots for High-Voltage Transmission Lines
Authors: Yang Zhiyong , Yan Kai , Zhang Ziyu , Duan Hua , Liu Xing , Li Yi , Zhang Daode , Yan Yu , Fan Shaosheng
Published: December 2023

This paper presents an anti-swing control method to prevent situations where inspection robots detach and fall off transmission lines during obstacle crossing due to excessive swing angles caused by the rotation of the robot around the transmission line. Firstly, an obstacle-crossing model for the inspection robot was constructed and the causes of robot swinging phenomena were analyzed, in addition to their impact on obstacle crossing stability. By combining this with the obstacle-crossing model, a moment balance equation was established for the inspection robot. This equation can be used to solve mapping relationships between body offset and the tilt angle of transmission line gripping arms. We propose an anti-swing control strategy by adjusting the angle of the transmission line gripping arm’s pitching joint to make the body offset approach zero, and by utilizing the advantages of fuzzy logic in the fuzzy PID algorithm compared with the traditional PID algorithm, it can adaptively avoid the occurrence of robot swinging phenomena. The experimental results of obstacle-crossing experiments under no wind and wind turbulence conditions indicated that the proposed anti-swing control method in this study can effectively keep the body offset to within 3 mm. Compared with the methods of not using anti-swing control and using traditional PID anti-swing control, in the absence of wind effects, the peak values of body offset were reduced by 96.53% and 18.85%, respectively. Under the influence of wind turbulence, the peak values of body offset were reduced by 97.02% and 27.12%, respectively. The effectiveness of the anti-swing control method proposed in this paper has thus been verified.
Growing Patterns of the Branca Chicken Breed—Concentrate vs. Maize-Based Diet
Authors: Soares Laura , Mata Fernando , Cerqueira Joaquim L. , Araújo José
Published: December 2023

Local chicken breeds are threatened with extinction. They must be preserved in order to maintain genetic diversity. The best strategy to preserve these breeds is to understand how they can be made interesting in production systems. With this strategy in mind, this study aimed to understand the growth patterns of the Branca breed, which is fed maize and commercial rations. A trial was conducted with N = 40 chickens, n = 10, in each of the combinations of gender and diet (cocks fed on ration, cocks fed on maize, hens fed on ration, and hens fed on maize). The first step was to determine the best nonlinear model to fit the growth data. After selecting the best fitting model, this was used to estimate the growth, relative growth rate, and instantaneous growth rate curves. The best fit was achieved with the Brody model. Ration-fed cocks grow faster and mature later, as the relative growth rate converges to zero later, while maize-fed hens show slower growth. Maize-fed cocks mature earlier as the relative growth rate converges to zero earlier. Maize-fed cocks and ration-fed hens show intermediate growth patterns compared to ration-fed cocks and maize-fed hens, and similar while comparing with each other. This is a slow-growing breed that reaches the slaughter-ready size at around the fifth month of age.
Baseline Susceptibility to a Novel dsRNA-Based Insecticide across US Populations of Colorado Potato Beetle
Authors: Pallis Samuel , Alyokhin Andrei , Manley Brian , Rodrigues Thais B. , Barnes Ethann , Narva Kenneth
Published: December 2023

The Colorado potato beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae) is an insect defoliator of the potato, Solanum tuberosum L. This species thrives in agricultural environments because of its flexible and complex life history, as well as its ability to evolve insecticide resistance. As a result, it has become a widely distributed agricultural pest. Ledprona (trade name Calantha) is a recently developed novel double-stranded RNA (dsRNA) insecticide that controls populations of Colorado potato beetle through RNA interference (RNAi). Previous studies have demonstrated the efficacy of ledprona through laboratory, greenhouse, and field studies. Colorado potato beetles from geographically distinct populations are known to vary in their response to insecticides, including experimental compounds based on RNAi. We tested the mortality and foliage consumption of beetles from different areas in the US treated with ledprona and found significant variation in both parameters. The beetles originating from New York were significantly less susceptible to ledprona in leaf disc assays compared to other populations. However, currently there is no evidence of reduced performance of ledprona against that population under field conditions, possibly because intoxicated beetles cannot withstand multiple stressors present in the field. The results of this study confirmed that the ledprona efficacy differs among geographically distinct populations, which may have implications for managing Colorado potato beetles.
Compression Strength and Critical Impact Speed of Typical Fertilizer Grains
Authors: Xin Mingjin , Jiang Zhiwen , Song Yuqiu , Cui Hongguang , Kong Aiju , Chi Bowen , Shan Renbao
Published: December 2023

The application of fertilizer is necessary for the growth and yield of crops, especially for paddy rice. Precision application is important for the fertilizer utilization rate and sustainable development of agriculture. However, the crushing of fertilizer grains will reduce the quality of fertilization, for the decrease in the size and mass of the fertilizer particles and the degree of crushing mainly depend on the physical and mechanical properties of the fertilizer grains. In this study, the compression strength and critical impact speed of four typical commonly used fertilizer grains, a compound fertilizer of nitrogen, phosphorus, and potassium (NPK compound fertilizer), organic fertilizer, large granular urea, and small granular urea, were measured and analyzed. The static compression test was carried out using a TMS-Pro texture analyzer and the results show that the four kinds of fertilizer grains are brittle materials, and their elastic moduli are 208 MPa, 233 MPa, 140 MPa, and 107 MPa, respectively; the theoretical impact model of fertilizer granules is established based on the compression test result and Hertz elastic contact theory, the theoretical formula for the critical impact speed of fertilizer grains is derived, and the theoretical critical impact strength and speed are worked out. An image capture system for the impact process of fertilizer grains was developed, and the impact test was conducted. The results show that the critical impact speed of the four kinds of fertilizer grains decreases with the increase in granule size, while the variance analysis shows that the effect is not significant. The comparison of the experimental results with the theoretical values shows that the theoretical formula could be used to predict the trends of the critical impact speed of fertilizer grains. The model was optimized with the MATLAB 2018 function fitting tool based on the test and analysis. The goodness of fit of the formula is 0.824, which is 13.43% greater than that of the original theoretical formula, indicating that the modified formula based on the compression test data might estimate the critical impact speed of the granular fertilizer with brittle material properties more accurately. The results may provide a reference for the parameter design of a precision fertilization machine.
Harnessing Solar Energy: A Novel Hybrid Solar Dryer for Efficient Fish Waste Processing
Authors: Deef Mohamed , Samy Helal Helal , El-Sebaee Islam , Nadimi Mohammad , Paliwal Jitendra , Ibrahim Ayman
Published: December 2023

Facing severe climate change, preserving the environment, and promoting sustainable development necessitate innovative global solutions such as waste recycling, extracting value-added by-products, and transitioning from traditional to renewable energy sources. Accordingly, this study aims to repurpose fish waste into valuable, nutritionally rich products and extract essential chemical compounds such as proteins and oils using a newly developed hybrid solar dryer (HSD). This proposed HSD aims to produce thermal energy for drying fish waste through the combined use of solar collectors and solar panels. The HSD, primarily composed of a solar collector, drying chamber, auxiliary heating system, solar panels, battery, pump, heating tank, control panel, and charging unit, has been designed for the effective drying of fish waste. We subjected the fish waste samples to controlled drying at three distinct temperatures: 45, 50, and 55 °C. The results indicated a reduction in moisture content from 75.2% to 24.8% within drying times of 10, 7, and 5 h, respectively, at these temperatures. Moreover, maximum drying rates of 1.10, 1.22, and 1.41 kgH2O/kg dry material/h were recorded at 45, 50, and 55 °C, respectively. Remarkable energy efficiency was also observed in the HSD’s operation, with savings of 79.2%, 75.8%, and 62.2% at each respective temperature. Notably, with an increase in drying temperature, the microbial load, crude lipid, and moisture content decreased, while the crude protein and ash content increased. The outcomes of this study indicate that the practical, solar-powered HSD can recycle fish waste, enhance its value, and reduce the carbon footprint of processing operations. This sustainable approach, underpinned by renewable energy, offers significant environmental preservation and a reduction in fossil fuel reliance for industrial operations.
Whole-Genome Investigation of Zoonotic Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Isolated from Pigs and Humans in Thailand
Authors: Narongpun Pawarut , Chanchaithong Pattrarat , Yamagishi Junya , Thapa Jeewan , Nakajima Chie , Suzuki Yasuhiko
Published: December 2023

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has been widespread globally in pigs and humans for decades. Nasal colonization of LA-MRSA is regarded as an occupational hazard to people who are regularly involved in livestock production. Our previous study suggested pig-to-human transmission caused by LA-MRSA clonal complex (CC) 398, using traditional molecular typing methods. Instead, this study aimed to investigate the zoonotic transmission of LA-MRSA CC398 using whole genome sequencing (WGS) technologies. A total of 63 LA-MRSA isolates were identified and characterized in Thailand. Further, the 16 representatives of LA-MRSA CC9 and CC398, including porcine and worker isolates, were subjected to WGS on the Illumina Miseq platform. Core-genome single nucleotide polymorphism (SNP)-based analyses verify the zoonotic transmission caused by LA-MRSA CC398 in two farms. WGS-based characterization suggests the emergence of a novel staphylococcal cassette chromosome (SCC) mec type, consisting of multiple cassette chromosome recombinase (ccr) gene complexes via genetic recombination. Additionally, the WGS analyses revealed putative multi-resistant plasmids and several cross-resistance genes, conferring resistance against drugs of last resort used in humans such as quinupristin/dalfopristin and linezolid. Significantly, LA-MRSA isolates, in this study, harbored multiple virulence genes that may become a serious threat to an immunosuppressive population, particularly for persons who are in close contact with LA-MRSA carriers.
Genomic Profiling of Multidrug-Resistant Swine Escherichia coli and Clonal Relationship to Human Isolates in Peru
Authors: Alvarez Luis , Carhuaricra Dennis , Palomino-Farfan Joel , Calle Sonia , Maturrano Lenin , Siuce Juan
Published: December 2023

The misuse of antibiotics is accelerating antimicrobial resistance (AMR) in Escherichia coli isolated from farm animals. The genomes of ten multidrug-resistant (MDR) E. coli isolates from pigs were analyzed to determine their sequence types, serotypes, virulence, and AMR genes (ARGs). Additionally, the relationship was evaluated adding all the available genomes of Peruvian E. coli from humans using the cgMLST + HierCC scheme. Two aEPEC O186:H11-ST29 were identified, of which H11 and ST29 are reported in aEPEC isolates from different sources. An isolate ETEC-O149:H10-ST100 was identified, considered a high-risk clone that is frequently reported in different countries as a cause of diarrhea in piglets. One ExPEC O101:H11-ST167 was identified, for which ST167 is an international high-risk clone related to urinary infections in humans. We identified many ARGs, including extended-spectrum β-lactamase genes, and one ETEC harboring the mcr-1 gene. CgMLST + HierCC analysis differentiated three clusters, and in two, the human isolates were grouped with those of swine in the same cluster. We observed that Peruvian swine MDR E. coli cluster with Peruvian E. coli isolates from healthy humans and from clinical cases, which is of great public health concern and evidence that AMR surveillance should be strengthened based on the One Health approach.