bluuebunny/crossref_metadata_2025 huggingface dataset:
ST-TransNet: A Spatiotemporal Transformer Network for Uncertainty Estimation from a Single Deterministic Precipitation Forecast
Authors: Wang Jingnan , Wang Xiaodong , Guan Jiping , Zhang Lifeng , Chang Tao , Yu Wei
Published: May 2024

The forecast uncertainty, particularly for precipitation, serves as a crucial indicator of the reliability of deterministic forecasts. Traditionally, forecast uncertainty is estimated by ensemble forecasting, which is computationally expensive since the forecast model is run multiple times with perturbations. Recently, deep learning methods have been explored to learn the statistical properties of ensemble prediction systems due to their low computational costs. However, accurately and effectively capturing the uncertainty information in precipitation forecasts remains challenging. In this study, we present a novel spatiotemporal transformer network (ST-TransNet) as an alternative approach to estimate uncertainty with ensemble spread and probabilistic forecasts, by learning from historical ensemble forecasts. ST-TransNet features a hierarchical structure for extracting multiscale features and incorporates a spatiotemporal transformer module with window-based attention to capture correlations in both spatial and temporal dimensions. Additionally, window-based attention can not only extract local precipitation patterns but also reduce computational costs. The proposed ST-TransNet is evaluated on the TIGGE ensemble forecast dataset and Global Precipitation Measurement (GPM) precipitation products. Results show that ST-TransNet outperforms both traditional and deep learning methods across various metrics. Case studies further demonstrate its ability to generate reasonable and accurate spread and probability forecasts from a single deterministic precipitation forecast. It demonstrates the capacity and efficiency of neural networks in estimating precipitation forecast uncertainty.
Spatial spillover effects of fiscal expenditure and economic opportunity on internal migration in Taiwan
Authors: Huang Hao-Chen , Hung Po-Hsun , Hung Chin-Fu , Liao Ting-Hsiu
Published: May 2024

The purpose of this study is to understand the determining factors of in-migrant population registration in various counties or cities in Taiwan. Panel data from counties and cities in Taiwan from 2000 to 2021 were adopted, and spatial econometric analysis was conducted using the spatial Durbin model. In terms of spatial spillover effects, the in-migrant population of each county or city is influenced by the fiscal expenditure and economic opportunity factors of neighboring counties or cities, such as (1) expenditure on education, science and culture, (2) number of employed population, (3) average annual regular income per household and (4) average disposable income per household.
Integrating challenge-based learning and design thinking in a course of reaction engines for aerospace
Authors: Díaz Palencia José Luis
Published: May 2024

This study presents an approach to aerospace engineering education based on the integration of challenge-based learning (CBL) and design thinking in a course on reaction engines. The paper describes how this approach addresses the evolving demands of the aerospace sector, particularly the need for sustainable propulsion systems. It provides a sistematic analysis, starting with a literature review that establishes some foundational understanding of CBL and design thinking while highlighting their importance in fostering problem-solving and critical thinking skills among engineering students. The main body of the paper explores the practical application of these methodologies in an aerospace course. It details a series of sessions designed to provide students with basic understanding of sustainable ideas in reaction engines. These sessions encourage students to engage in critical thinking and collaborative problem-solving, aligning with real-world environmental concerns in aerospace propulsion. In addition, we present the students` feedback concerning the classroom sessions based on a semi-structured interview technique to assess the effectiveness of the teaching approach. The feedback, analyzed from these interviews, indicates a positive reception of CBL and design thinking. Students appreciated the interactive nature of the sessions and the emphasis on real-world problem-solving. However, challenges such as balancing theoretical and practical aspects, pacing, and providing clear guidelines were noted for future improvement. The study emphasizes the need for ongoing adaptation and iteration of teaching methodologies, informed by regular student feedback, to ensure their effectiveness in preparing students for future challenges in the aerospace sector.
“All great warriors have long hair”: Tourism and shifting Indigenous masculinities in Napo, Ecuador
Authors: Benitez Ernesto J.
Published: May 2024

As young Indigenous Kichwa men begin working as local tour guides in the small city of Tena in the Ecuadorian Amazon, they go through complex processes of transition and adjustment navigating entanglements of tourists’ expectations, familial obligations, and desires for socioeconomic mobility. For many, there is the additional challenge of emphasizing their Indigenous identities, given the pervasive anti-Indigenous racism to which they are subjected within Ecuadorian society. I argue that work in tourism has provided young Kichwa men with opportunities for self-transformation, at once attractive and fraught with contradictions. On one hand, they have come to perceive their Indigeneity as an asset rather than a liability and are increasingly able to contest long-standing racism at the local level. On the other hand, their urban lifestyles, pursuit of intimate relationships with foreign tourists and sometimes dismissive attitudes towards rural Kichwa people have distanced them socially from the broader Kichwa population. By exploring these complex affective processes, their impacts on local dynamics, and the multiple and often conflicting understandings of Indigeneity that are constantly being produced and negotiated in these spaces, I seek to broaden the scope of scholarly debates on the impact of cultural tourism in Indigenous communities. I also engage with recent scholarship on Indigenous masculinities to discuss the possibilities and limitations of masculinity as a tool of decolonization for Indigenous peoples.
Working on the future of group analysis – breaking the certainty
Authors: Satarić Jelica
Published: May 2024

The idea of a social nature of humans clarifies that the phenomena, usually called intrapsychic, such as mind, freedom and ethics are shared property of the group. How does this idea manifest in the group situation? I present some of my reflections and experiences from practice related to this issue. We can see how the desire for sharing and addressing others creates a new, deeper understanding of relations in the group. I describe how a fellow member unpredictably can become the Other. The I-Thou relations, developed in the group, are ethical in their essence, and it is in these ethical relations that trust is created. Such processes never give the feeling of complete understanding and equality. Something is always missing and this is what drives the group to go beyond.
Helping Fathers in the Perinatal Period: A Mapping Review of Paternal Mental Health Issues for Social Workers
Authors: Brennan Matthew , Davis Curtis
Published: May 2024

The absence of father-focused perinatal research and the prioritizing of child- and family-focused perinatal research is particularly noticeable within social work literature. While recent social work scholarship on research related to paternal mental health and the experience of fathers exists, it is sparse. Focused on what is currently known about helping fathers in the perinatal period, this mapping review was done to explore existing and relevant knowledge related to practices to better serve fathers and their families. Themes among the existing knowledge related to developmental change, traumatic birth, paternal mental health, interventions, neurobiology, and policy will be discussed before concluding with a focus on emerging focal points for future research related to nurturing fathers during perinatal care.
Establishing Healthcare Discrimination: An Analysis of Scandinavian Equality Boards
Authors: Ó Cathaoir Katharina
Published: May 2024

Discrimination in healthcare is a pervasive issue faced by patients, affecting their access to treatment and overall well-being. This article examines the forms of healthcare discrimination recognised by Scandinavian equality boards through a comparative analysis of their decisions. While social science studies have established the existence of discrimination based on ethnicity, race, gender, sexuality, and age, proving such discrimination in legal terms poses significant challenges. An analysis of board decisions reveals that patients face barriers in establishing legally actionable discrimination, as perceived discriminatory conduct may not meet the criteria for legal claims. Additionally, equality boards are often hesitant to intervene in medical decision-making processes, further complicating the path to legal recourse. Lack of evidentiary support, especially in cases of unconscious bias, makes it difficult for some patients to substantiate claims of discrimination. The findings underscore the complexities of addressing healthcare discrimination through legal means. To effectively combat discrimination, there is a need to clarify the goals of discrimination law in the healthcare context and consider its future application within the broader context of human rights and equality.
A Space of Discovery and Refuge
Authors: Baker Olivia , Rogers Baker
Published: May 2024

Olivia Baker and Baker Rogers on drag performance and gender identity.
Obtaining Consent for Research on Risky Behaviours Among Adolescents in Canada: A Scoping Review
Authors: MacNeill Lillian , MacNeill A. Luke , Doucet Shelley , Luke Alison , Goudreau Alex
Published: May 2024

This scoping review explores current practices for obtaining consent in research on risky behaviours among adolescents in Canada. The JBI methodology for scoping reviews was used. The database search was conducted in August 2021 and updated in November 2022. Papers published in 2010 or later were included. Extracted data included study characteristics, sample characteristics, and consent procedures. The review included 83 reports covering 57 studies. Nearly 60% of studies relied on adolescent self-consent for participation. Adolescent self-consent was more common than parental/guardian consent for studies using in-person research methods, older adolescent groups, and particularly vulnerable populations. Parental/guardian consent was more common for studies using younger age groups and general population samples. Adolescent self-consent was more common than parental/guardian consent for most risky behaviours covered by this review. These results provide insight into current consent practices in this area and offer guidance to researchers and institutional review boards in Canada.
The relationship of KRAS expression with KRAS status, prognosis, and tumor-infiltrated T lymphocytes in colorectal cancer
Authors: Zhou Yebohao , Zeng Ziwei , Li Ze , Ruan Lei , Xie Hao , Ye Fujin , Huang Liang , Liu Huashan , Kang Liang
Published: May 2024

Background:

The significance of Kirsten rat sarcoma viral oncogene (KRAS) mutation in colorectal cancer (CRC) is well established; yet, its association with KRAS expression and prognosis warrants further investigation. While high KRAS expression is commonly linked with poorer prognosis in other cancers, its role in CRC remains relatively understudied.

Objective:

To explore the correlation between KRAS expression, KRAS status, prognosis, and tumor-infiltrating T lymphocyte density in CRC.

Design:

Single-center retrospective study.

Methods:

Conducted between 2010 and 2020, this study utilized tumor samples to assess KRAS expression and quantify CD3+/CD8+ T lymphocytes. The Cox proportional hazards model and linear regression analysis were employed to examine the relationship between KRAS expression, prognosis, and tumor-infiltrating T lymphocytes.

Results:

This study included 265 CRC patients who underwent radical surgery. No significant association was observed between KRAS expression and KRAS status ( p > 0.05). High KRAS expression was associated with poorer overall survival and disease-free survival ( p < 0.05). Subgroup analysis revealed that high KRAS expression remained indicative of a worse prognosis in the group with mismatch repair-deficient (dMMR) and KRAS mutant type ( p < 0.05). Multivariate analysis confirmed KRAS expression as an unfavorable prognostic factor ( p < 0.05). However, the significance of KRAS expression was lost in the dMMR and KRAS mutant-type group regarding overall survival ( p > 0.05). Notably, KRAS expression showed a negative correlation with the density of CD8+ T lymphocytes in tumor tissue ( p < 0.05), a finding also observed in the dMMR group ( p < 0.05).

Conclusion:

No association was found between KRAS expression and KRAS mutation status in CRC. Higher KRAS expression was indicative of poorer prognosis for CRC patients, except for those with proficient mismatch repair and KRAS wild type. In addition, in patients with dMMR, KRAS expression was associated with a lower density of CD8+ T lymphocytes in tumor tissue.
UPLC-Q-TOF-MSE Based Profiling of the Chemical Composition of Different Parts of Tetrastigma hemsleyanum
Authors: Peng Lingxia , Yin Feng , Li Xiuyue , Fang Jiahao , Li Hongju , Xu Xinhan , Xia Pengguo , Liang Zongsuo , Zhang Xiaodan
Published: May 2024

Objectives: The differences in chemical constituents in different parts of Tetrastigma hemsleyanum were analyzed. Methods: The contents of total phenols, total flavonoids, and polysaccharides in methanol extracts from different parts of T. hemsleyanum in Zhejiang were determined, and the chemical components of different parts of T. hemsleyanum were collected by ultra-performance liquid chromatography-tandem quadrupole-time-of-flight mass spectrometry. The differential index components of different parts of T. hemsleyanum were identified and analyzed by accurate mass-to-charge ratio of primary mass spectrometry and fragment ion of secondary mass spectrometry with reference spectrum and software database search and related literature reports. Results: A total of 20 components were identified, including 13 identified in root tubers, 7 in fibrous roots and 8 in leaves, and the structural cleavage of its compounds was analyzed. Conclusion: It provides a possibility and theoretical basis for the future use of the whole plant of T. hemsleyanum as medicine.
Unexpected discovery of fetal bones instead of an intrauterine device: A unique gynecological case report
Authors: Yared Georges , al Hassan Jihad , Tachdjian Annie , El Hajjar Charlotte , Ghazal Kariman
Published: May 2024

This case report details an unusual and unexpected finding in a 37-year-old woman with a history of two cesarean sections, who had an intrauterine device implanted. The patient presented with symptoms of abnormal uterine bleeding and dysmenorrhea. An initial ultrasound confirmed the presence of the intrauterine device. However, a startling discovery was made during the intrauterine device removal procedure: fetal bones were found within the patient. This case underscores the importance of thorough diagnostic evaluations in gynecological practice, particularly when dealing with patients who have complex gynecological histories. Significantly, it brings to light the necessity of employing hysteroscopy for comprehensive diagnostic assessment in cases of abnormal uterine bleeding post-abortion. This approach could aid in identifying rare and unexpected findings, such as retained fetal bones, which might be missed by conventional ultrasound. The report emphasizes the need for vigilance and thoroughness in gynecological examinations and contributes to the understanding of potential complications and anomalies associated with intrauterine device usage and post-abortion care.
Idiopathic pediatric nasal septal and epidural abscess: A case report and review of the literature
Authors: Macaskill James Robert , Moolman Nico
Published: May 2024

Nasal septal abscess is an uncommon otolaryngologic condition with little reported in the literature. Most commonly arising secondary to hematoma, idiopathic abscess formation is rare. A previously healthy 13-year-old male with no preceding nasal hematoma or trauma presented with rhinorrhea, nasal pain, and obstruction. Initial incision and drainage were not curative; the patient returned to care with complaints of new-onset headache. Neuroimaging revealed abscess recurrence alongside pansinusitis and epidural empyema. The patient was transferred to a tertiary care center for joint otolaryngologic and neurosurgical care. The patient’s postoperative course was uncomplicated. Nasal septal abscesses have become increasingly uncommon, but they still occur. Prompt treatment is warranted to mitigate the potential risk of further intracranial spread and facial deformity, as seen in this case.
Endo-infundibulotomy of a hydrocalyx, mysterious pains after percutaneous nephrolithotomy: A case report
Authors: Basiri Abbas , Narouie Behzad , Dadpour Mehdi , Najafi Darya , Momeni Hamidreza , Jadidi Sajedeh , Radpour Negar
Published: May 2024

Hydrocalyx is a dilated renal calyx due to obstruction of the infundibulum and a rare complication after percutaneous nephrolithotomy. We present a 22-year-old girl with hydrocalyx who had following percutaneous nephrolithotomy and its management. A 22-year-old female with recurrent right flank pain underwent percutaneous nephrolithotomy for a kidney stone. Despite interventions such as endoscopic infundibulotomy and double J stenting, the patient experienced persistent symptoms. Laparoscopy ultimately led to improvement. Hydrocalyx is a rare but significant complication post-percutaneous nephrolithotomy. Minimally invasive procedures and endoscopic interventions are the primary treatment options. Laparoscopy may be considered if initial interventions fail. Formation of hydrocalyx after percutaneous nephrolithotomy is a rare yet considerable complication and there are only a few articles in this field available to our knowledge.
The Continuity of eSports Athletes’ Careers: Skill Transformation, Personal Development, and Well-Being
Authors: Zhao Yupei , Meng-Lewis Yue , Ni Bin , Lewis Gavin , Lin Zhongxuan
Published: May 2024

Despite the rapid growth of the eSports industry with respect to its economic scale and the demand for eSports players, the career transformation experiences and well-being of eSports athletes have been largely overlooked. This study aims to explore eSports athletes’ personal development in terms of career continuity, associated skill transformation, and well-being after retirement. Employing non-participatory observations and semi-structured interviews, we unpack two different pedagogical contexts of retiring eSports athletes: one is “continuity paths” (three transformation options and associated skill sets), and the other is “desire for continuity” (psychological strengths and explicit tacit knowledge). Our findings provide practical guidance for the career transition experiences of eSports athletes and contribute to understanding the sustainable framework required for the self-development of talent within eSports education and the eSports industry. The findings suggest that psychological consultants and athletic rehabilitation therapists should be employed to provide professional advice, interventions, and treatment to eSports athletes before and after retirement.
Decompression Alone vs Decompression and Fusion: Spin in Abstracts of Systematic Reviews and Meta-Analysis
Authors: Taka Taha M. , Avetisian Henry , El-Farra Mohamed H. , Gulbransen Matthew , Danisa Olumide
Published: May 2024

Study Design

Cross-sectional.

Objectives

Spin, a prevalent bias, can distort outcomes in well-validated research. Treatment of lumbar stenosis with spondylolisthesis through decompression alone (DA) vs decompression and fusion (DF) remains a controversial topic. We aimed to identify the prevalence of spin in meta-analyses and systematic reviews regarding DA vs DF in the treatment of spinal stenosis with concomitant degenerative spondylolisthesis.

Methods

MEDLINE, Web of Science, and Google Scholar were searched for meta-analyses and systematic reviews comparing DA vs DF treatment of lumbar spinal stenosis accompanied by degenerative spondylolisthesis. Each study was evaluated for the nine most severe spin types. We also explored the association between spin and methodological quality of a systematic review using the revised A Measurement Tool to Assess Systematic Reviews appraisal tool.

Results

The search yielded 1506 articles, of which 13 met inclusion. It was found that 46.2% (6/13) of the articles contained spin within the abstract. Of the nine most severe types, type 5 was found to be the most prevalent (4/13, 30.8%), followed by types 9 (2/13, 15.4%), 3 (1/13, 7.7%), 4 (1/13, 7.7%), and 6 (1/13, 7.7%). Spin types 1, 2, 7 and 8 were not found. According to AMSTAR-2, 53.8% (7/13) of the studies were appraised as “critically low” quality and 46.2% (6/13) as “low” quality.

Conclusion

This study demonstrated the presence of spin in 46.2% of abstracts pertaining to the treatment for spinal stenosis with degenerative spondylolisthesis. Spine surgeons should learn to recognize spin as they review articles before implementing them into practice.
Postoperative Opioid Usage and Disposal Strategies After Arthroscopic Procedures in a Young Cohort: A Prospective Observational Study
Authors: Johns William L. , Johnson Emma E. , Brutico Joseph , Sherman Matthew B. , Freedman Kevin B. , Emper William , Salvo John P. , Hammoud Sommer
Published: May 2024

Background:

Although several studies have noted that patients are routinely overprescribed opioids, few have reported usage after arthroscopic surgery.

Purpose:

To determine opioid consumption and allocation for unused opioids after common arthroscopic surgeries.

Study Design:

Case series; Level of evidence, 4.

Methods:

Patients between the ages of 15 and 40 years who were scheduled to undergo anterior cruciate ligament reconstruction (ACLR), labral repair of the hip or shoulder, meniscectomy, or meniscal repair were prospectively enrolled. Patients were prescribed either 5 mg hydrocodone-325 mg acetaminophen or 5 mg oxycodone-325 mg acetaminophen based on surgeon preference. Patients completed a daily opioid usage survey during the 2-week postoperative period. In addition, patients completed a survey on postoperative day 21 inquiring about continued opioid use and medication disposal, if applicable. Opioid medication consumption was converted to morphine milligram equivalents (MMEs).

Results:

Of the 200 patients who were enrolled in the study, 176 patients had sufficient follow-up after undergoing 85 (48%) ACLR, 26 (14.8%) hip labral repair, 34 (19.3%) shoulder labral repair, 18 (10.2%) meniscectomy, and 13 (7.4%) meniscal repair procedures. Mean age was 26.1 years (SD, 7.38); surgeons prescribed a mean of 26.6 pills whereas patients reported consuming a mean of 15.5 pills. The mean MME consumption in the 14 days after each procedure was calculated: ACLR (95.7; 44% of prescription), hip labral repair (84.8; 37%), shoulder labral repair (57.2; 35%), meniscectomy (18.4; 27%), and meniscal repair (32.1; 42%). This corresponded to approximately 39% of the total opioid prescription being utilized across all procedures. Mean MME consumption was greatest on postoperative day 1 in hip, shoulder, and meniscal procedures and on postoperative day 2 in ACLR. Only 7.04% of patients reported continued opioid use in the third postoperative week. Patients had a mean of 11 unused pills or 77.7 MMEs remaining. Of the patients with remaining medication, 24.7% intended to keep their medication for future use.

Conclusion:

The results of our study indicate that patients who undergo the aforementioned arthroscopic procedures consume <75 MMEs in the 2-week postoperative period, translating into a mean of 10 to 15 pills consumed. Approximately 60% of total opioids prescribed went unused, and one-fourth of patients intended to keep their remaining medication for future usage. We have provided general prescribing guidelines and recommend that surgeons carefully consider customizing their opioid prescriptions on the basis of procedure site to balance optimal postoperative analgesia with avoidance of dissemination of excess opioids.
Real-Time Co-optimization of Gear Shifting and Engine Torque for Predictive Cruise Control of Heavy-Duty Trucks
Authors: Chu Hongqing , Na Xiaoxiang , Liu Huan , Wang Yuhai , Yang Zhuo , Zhang Lin , Chen Hong
Published: May 2024

Fuel consumption is one of the main concerns for heavy-duty trucks. Predictive cruise control (PCC) provides an intriguing opportunity to reduce fuel consumption by using the upcoming road information. In this study, a real-time implementable PCC, which simultaneously optimizes engine torque and gear shifting, is proposed for heavy-duty trucks. To minimize fuel consumption, the problem of the PCC is formulated as a nonlinear model predictive control (MPC), in which the upcoming road elevation information is used. Finding the solution of the nonlinear MPC is time consuming; thus, a real-time implementable solver is developed based on Pontryagin’s maximum principle and indirect shooting method. Dynamic programming (DP) algorithm, as a global optimization algorithm, is used as a performance benchmark for the proposed solver. Simulation, hardware-in-the-loop and real-truck experiments are conducted to verify the performance of the proposed controller. The results demonstrate that the MPC-based solution performs nearly as well as the DP-based solution, with less than 1% deviation for testing roads. Moreover, the proposed co-optimization controller is implementable in a real-truck, and the proposed MPC-based PCC algorithm achieves a fuel-saving rate of 7.9% without compromising the truck’s travel time.
Association between urinary phthalate metabolites and renal function in late pregnant women
Authors: Hong Qifu , Pu Tao , Li Maojie , Chen Zhongbao , Liu Xingyan , Zeng Rong , Zhang Mingzhe , Dai Lulu , An Songlin , Shen Xubo , Shang Xuejun , Zhou Yuanzhong , Tian Kunming
Published: May 2024

Evidence about associations of phthalates metabolites with increased serum uric acid (SUA) levels in pregnant women remains unknown. To address this, we conducted a cross-sectional population-based study including 851 pregnant women from Zunyi birth cohort in southwest China. Multiple linear regression models were used to explore single relationships between ten urinary phthalate metabolites with SUA and estimated glomerular filtration rate (eGFR). And then, the overall relationship of phthalate mixture with SUA and eGFR were determined by principal component analysis (PCA) and quantile g-computation (Q-g) analysis. The multivariable linear regression showed that mono-butyl phthalate (MBP), mono-octyl phthalate (MOP) and mono-benzyl phthalate (MBzP) were positively associated with SUA, while mono (2-ethylhexyl) phthalate (MEHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were associated with increased eGFR level. Moreover, PCA analysis suggested that phthalate mixture was positively associated with SUA, and MOP, MBzP and MEHP appeared to be the major contributors. Furthermore, Q-g regression showed that each quantile increase in phthalate mixture was associated with 3.27% higher SUA (95% CI 0.21%, 6.41%). Our results imply that phthalate metabolites were associated with higher SUA in late pregnant women, and MBP, MBzP and MOP might be the major drivers. So, a health perinatal duration should be seriously taken to counteract the environment-related dysregulated kidney function.
Accuracy of genomic prediction using multiple Atlantic salmon populations
Authors: Ajasa Afees A. , Boison Solomon A. , Gjøen Hans M. , Lillehammer Marie
Published: May 2024

Background

The accuracy of genomic prediction is partly determined by the size of the reference population. In Atlantic salmon breeding programs, four parallel populations often exist, thus offering the opportunity to increase the size of the reference set by combining these populations. By allowing a reduction in the number of records per population, multi-population prediction can potentially reduce cost and welfare issues related to the recording of traits, particularly for diseases. In this study, we evaluated the accuracy of multi- and across-population prediction of breeding values for resistance to amoebic gill disease (AGD) using all single nucleotide polymorphisms (SNPs) on a 55K chip or a selected subset of SNPs based on the signs of allele substitution effect estimates across populations, using both linear and nonlinear genomic prediction (GP) models in Atlantic salmon populations. In addition, we investigated genetic distance, genetic correlation estimated based on genomic relationships, and persistency of linkage disequilibrium (LD) phase across these populations.

Results

The genetic distance between populations ranged from 0.03 to 0.07, while the genetic correlation ranged from 0.19 to 0.99. Nonetheless, compared to within-population prediction, there was limited or no impact of combining populations for multi-population prediction across the various models used or when using the selected subset of SNPs. The estimates of across-population prediction accuracy were low and to some extent proportional to the genetic correlation estimates. The persistency of LD phase between adjacent markers across populations using all SNP data ranged from 0.51 to 0.65, indicating that LD is poorly conserved across the studied populations.

Conclusions

Our results show that a high genetic correlation and a high genetic relationship between populations do not guarantee a higher prediction accuracy from multi-population genomic prediction in Atlantic salmon.
Identification and expression analysis of the Xyloglucan transglycosylase/hydrolase (XTH) gene family under abiotic stress in oilseed (Brassica napus L.)
Authors: Chen Jingdong , Wan Heping , Zhao Huixia , Dai Xigang , Wu Wanjin , Liu Jin , Xu Jinsong , Yang Rui , Xu Benbo , Zeng Changli , Zhang Xuekun
Published: May 2024

XTH genes are key genes that regulate the hydrolysis and recombination of XG components and plays role in the structure and composition of plant cell walls. Therefore, clarifying the changes that occur in XTHs during plant defense against abiotic stresses is informative for the study of the plant stress regulatory mechanism mediated by plant cell wall signals. XTH proteins in Arabidopsis thaliana was selected as the seed sequences in combination with its protein structural domains, 80 members of the BnXTH gene family were jointly identified from the whole genome of the Brassica napus ZS11, and analyzed for their encoded protein physicochemical properties, phylogenetic relationships, covariance relationships, and interoperating miRNAs. Based on the transcriptome data, the expression patterns of BnXTHs were analyzed in response to different abiotic stress treatments. The relative expression levels of some BnXTH genes under Al, alkali, salt, and drought treatments after 0, 6, 12 and 24 h were analyzed by using qRT-PCR to explore their roles in abiotic stress tolerance in B. napus. BnXTHs showed different expression patterns in response to different abiotic stress signals, indicating that the response mechanisms of oilseed rape against different abiotic stresses are also different. This paper provides a theoretical basis for clarifying the function and molecular genetic mechanism of the BnXTH gene family in abiotic stress tolerance in rapeseed.
Unravelling the metabolomic diversity of pigmented and non-pigmented traditional rice from Tamil Nadu, India
Authors: Subramanian Venkatesan , Dhandayuthapani Udhaya Nandhini , Kandasamy Senthilraja , Sivaprakasam Jidhu Vaishnavi , Balasubramaniam Prabha , Shanmugam Mohan Kumar , Nagappan Sriram , Elangovan Subramanian , Subramani Umesh Kanna , Palaniyappan Kumaresan , Vellingiri Geethalakshmi , Muthurajan Raveendran
Published: May 2024

Rice metabolomics is widely used for biomarker research in the fields of pharmacology. As a consequence, characterization of the variations of the pigmented and non-pigmented traditional rice varieties of Tamil Nadu is crucial. These varieties possess fatty acids, sugars, terpenoids, plant sterols, phenols, carotenoids and other compounds that plays a major role in achieving sustainable development goal 2 (SDG 2). Gas-chromatography coupled with mass spectrometry was used to profile complete untargeted metabolomics of Kullkar (red colour) and Milagu Samba (white colour) for the first time and a total of 168 metabolites were identified. The metabolite profiles were subjected to data mining processes, including principal component analysis (PCA), Orthogonal Partial Least Square Discrimination Analysis (OPLS-DA) and Heat map analysis. OPLS-DA identified 144 differential metabolites between the 2 rice groups, variable importance in projection (VIP) ≥ 1 and fold change (FC) ≥ 2 or FC ≤ 0.5. Volcano plot (64 down regulated, 80 up regulated) was used to illustrate the differential metabolites. OPLS-DA predictive model showed good fit (R2X = 0.687) and predictability (Q2 = 0.977). The pathway enrichment analysis revealed the presence of three distinct pathways that were enriched. These findings serve as a foundation for further investigation into the function and nutritional significance of both pigmented and non-pigmented rice grains thereby can achieve the SDG 2.
The association between population health management tools and clinician burnout in the United States VA primary care patient-centered medical home
Authors: Wang Jane , Leung Lucinda , Jackson Nicholas , McClean Michael , Rose Danielle , Lee Martin L. , Stockdale Susan E.
Published: May 2024

Background

Technological burden and medical complexity are significant drivers of clinician burnout. Electronic health record(EHR)-based population health management tools can be used to identify high-risk patient populations and implement prophylactic health practices. Their impact on clinician burnout, however, is not well understood. Our objective was to assess the relationship between ratings of EHR-based population health management tools and clinician burnout.

Methods

We conducted cross-sectional analyses of 2018 national Veterans Health Administration(VA) primary care personnel survey, administered as an online survey to all VA primary care personnel (n = 4257, response rate = 17.7%), using bivariate and multivariate logistic regressions. Our analytical sample included providers (medical doctors, nurse practitioners, physicians’ assistants) and nurses (registered nurses, licensed practical nurses). The outcomes included two items measuring high burnout. Primary predictors included importance ratings of 10 population health management tools (eg. VA risk prediction algorithm, recent hospitalizations and emergency department visits, etc.).

Results

High ratings of 9 tools were associated with lower odds of high burnout, independent of covariates including VA tenure, team role, gender, ethnicity, staffing, and training. For example, clinicians who rated the risk prediction algorithm as important were less likely to report high burnout levels than those who did not use or did not know about the tool (OR 0.73; CI 0.61-0.87), and they were less likely to report frequent burnout (once per week or more) (OR 0.71; CI 0.60-0.84).

Conclusions

Burned-out clinicians may not consider the EHR-based tools important and may not be using them to perform care management. Tools that create additional technological burden may need adaptation to become more accessible, more intuitive, and less burdensome to use. Finding ways to improve the use of tools that streamline the work of population health management and/or result in less workload due to patients with poorly managed chronic conditions may alleviate burnout. More research is needed to understand the causal directional of the association between burnout and ratings of population health management tools.
Regular source of primary care and health services utilisation among Brazilian elderly with mental-physical multimorbidity
Authors: Batista Sandro Rogério Rodrigues , Sousa Ana Luiza Lima , Nunes Bruno Pereira , Rodrigues Rodolfo Rêgo Deusdará , Jardim Paulo Cesar Brandão Veiga
Published: May 2024

Background

In ageing populations, multimorbidity is a complex challenge to health systems, especially when the individuals have both mental and physical morbidities. Although a regular source of primary care (RSPC) is associated with better health outcomes, its relation with health service utilisation in elderly patients with mental-physical multimorbidity (MP-MM) is scarce.

Objective

This study explored the relations among health service utilisation, presence of RSPC and MP-MM among elderly Brazilians.

Methods

A national cross-sectional study performed with data from national representative samples from the Brazilian National Health Research (PNS, in Portuguese; Pesquisa Nacional de Saúde) carried out in 2013 with 11,177 elderly Brazilian people. MP-MM was defined as the presence of two or more morbidities, including at least one mental morbidity, and was evaluated using a list of 16 physical and mental morbidities. The RSPC was analysed by the presence of regular font of care in primary care and health service utilisation according to the demand for health services ≤ 15 days, medical consultation ≤ 12 months, and hospitalisation ≤ 1 year. Frequency description of variables and bivariate association were performed using Stata v.15.2 software.

Results

The majority of individuals was female (56.4%), and their mean age was 69.8 years. The observed prevalence of MP-MM was 12.2%. Individuals with MP-MM had higher utilisation of health services when compared to those without MP-MM. RSPC was present at 36.5% and was higher in women (37.8% vs. 34.9%). There was a lower occurrence of hospitalisation ≤ 1 year among MP-MM individuals with RSPC and without a private plan of health.

Conclusion

Our findings demonstrate that RSPC can be an important component of care in elderly individuals with MP-MM because it was associated with lower occurrence of hospitalisation, mainly in those that have not a private plan of health. Longitudinal studies are necessary to confirm these findings.
Integrated approach of federated learning with transfer learning for classification and diagnosis of brain tumor
Authors: Albalawi Eid , T.R. Mahesh , Thakur Arastu , Kumar V. Vinoth , Gupta Muskan , Khan Surbhi Bhatia , Almusharraf Ahlam
Published: May 2024

Brain tumor classification using MRI images is a crucial yet challenging task in medical imaging. Accurate diagnosis is vital for effective treatment planning but is often hindered by the complex nature of tumor morphology and variations in imaging. Traditional methodologies primarily rely on manual interpretation of MRI images, supplemented by conventional machine learning techniques. These approaches often lack the robustness and scalability needed for precise and automated tumor classification. The major limitations include a high degree of manual intervention, potential for human error, limited ability to handle large datasets, and lack of generalizability to diverse tumor types and imaging conditions.To address these challenges, we propose a federated learning-based deep learning model that leverages the power of Convolutional Neural Networks (CNN) for automated and accurate brain tumor classification. This innovative approach not only emphasizes the use of a modified VGG16 architecture optimized for brain MRI images but also highlights the significance of federated learning and transfer learning in the medical imaging domain. Federated learning enables decentralized model training across multiple clients without compromising data privacy, addressing the critical need for confidentiality in medical data handling. This model architecture benefits from the transfer learning technique by utilizing a pre-trained CNN, which significantly enhances its ability to classify brain tumors accurately by leveraging knowledge gained from vast and diverse datasets.Our model is trained on a diverse dataset combining figshare, SARTAJ, and Br35H datasets, employing a federated learning approach for decentralized, privacy-preserving model training. The adoption of transfer learning further bolsters the model’s performance, making it adept at handling the intricate variations in MRI images associated with different types of brain tumors. The model demonstrates high precision (0.99 for glioma, 0.95 for meningioma, 1.00 for no tumor, and 0.98 for pituitary), recall, and F1-scores in classification, outperforming existing methods. The overall accuracy stands at 98%, showcasing the model’s efficacy in classifying various tumor types accurately, thus highlighting the transformative potential of federated learning and transfer learning in enhancing brain tumor classification using MRI images.
Red cell distribution width to lymphocyte ratio could serve as a new inflammatory biomarker for predicting hematoma expansion in patients with intracerebral hemorrhage
Authors: Guilan Milad Babaei , Bagheri Seyed Reza , Roshani Rezvan , Alimohammadi Ehsan
Published: May 2024

Background

Hematoma expansion is a critical factor associated with increased mortality and adverse outcomes in patients with intracerebral hemorrhage (ICH). Identifying and preventing hematoma expansion early on is crucial for effective therapeutic intervention. This study aimed to investigate the potential association between the Red cell distribution width to lymphocyte ratio (RDWLR) and hematoma expansion in ICH patients.

Methods

We conducted a retrospective analysis of clinical data from 303 ICH patients treated at our department between May 2018 and May 2023. Demographic, clinical, radiological, and laboratory data, including RDWLR upon admission, were assessed. Binary logistic regression analysis was employed to determine independent associations between various variables and hematoma expansion.

Results

The study included 303 ICH patients, comprising 167 (55.1%) males and 136 (44.9%) females, with a mean age of 65.25 ± 7.32 years at admission. Hematoma expansion occurred in 73 (24.1%) cases. Multivariate analysis revealed correlations between hematoma volume at baseline (OR, 2.73; 95% CI: 1.45 -4,78; P < 0.001), admission systolic blood pressure (OR, 2.98 ; 95% CI: 1.54–4.98; P < 0.001), Glasgow Coma Scale (GCS) (OR, 1.58; 95% CI: 1.25–2.46; P = 0.017), and RDWLR (OR, 1.58; 95% CI: 1.13–2.85; P = 0.022) and hematoma expansion in these patients.

Conclusions

Our findings suggest that RDWLR could serve as a new inflammatory biomarker for hematoma expansion in ICH patients. This cost-effective and readily available biomarker has the potential for early prediction of hematoma expansion in these patients.
Associations between anxiety, sleep, and blood pressure parameters in pregnancy: a prospective pilot cohort study
Authors: Miller Hayley E. , Simpson Samantha L. , Hurtado Janet , Boncompagni Ana , Chueh Jane , Shu Chi-Hung , Barwick Fiona , Leonard Stephanie A. , Carvalho Brendan , Sultan Pervez , Aghaeepour Nima , Druzin Maurice , Panelli Danielle M.
Published: May 2024

Background

The potential effect modification of sleep on the relationship between anxiety and elevated blood pressure (BP) in pregnancy is understudied. We evaluated the relationship between anxiety, insomnia, and short sleep duration, as well as any interaction effects between these variables, on BP during pregnancy.

Methods

This was a prospective pilot cohort of pregnant people between 23 to 36 weeks’ gestation at a single institution between 2021 and 2022. Standardized questionnaires were used to measure clinical insomnia and anxiety. Objective sleep duration was measured using a wrist-worn actigraphy device. Primary outcomes were systolic (SBP), diastolic (DBP), and mean (MAP) non-invasive BP measurements. Separate sequential multivariable linear regression models fit with generalized estimating equations (GEE) were used to separately assess associations between anxiety (independent variable) and each BP parameter (dependent variables), after adjusting for potential confounders (Model 1). Additional analyses were conducted adding insomnia and the interaction between anxiety and insomnia as independent variables (Model 2), and adding short sleep duration and the interaction between anxiety and short sleep duration as independent variables (Model 3), to evaluate any moderating effects on BP parameters.

Results

Among the 60 participants who completed the study, 15 (25%) screened positive for anxiety, 11 (18%) had subjective insomnia, and 34 (59%) had objective short sleep duration. In Model 1, increased anxiety was not associated with increases in any BP parameters. When subjective insomnia was included in Model 2, increased DBP and MAP was significantly associated with anxiety (DBP: β 6.1, p = 0.01, MAP: β 6.2 p < 0.01). When short sleep was included in Model 3, all BP parameters were significantly associated with anxiety (SBP: β 9.6, p = 0.01, DBP: β 8.1, p < 0.001, and MAP: β 8.8, p < 0.001). No moderating effects were detected between insomnia and anxiety (p interactions: SBP 0.80, DBP 0.60, MAP 0.32) or between short sleep duration and anxiety (p interactions: SBP 0.12, DBP 0.24, MAP 0.13) on BP.

Conclusions

When including either subjective insomnia or objective short sleep duration, pregnant people with anxiety had 5.1–9.6 mmHg higher SBP, 6.1–8.1 mmHg higher DBP, and 6.2–8.8 mmHg higher MAP than people without anxiety.