bluuebunny/crossref_metadata_2025 huggingface dataset:
Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in an Alzheimer’s disease mouse model
Authors: Trinklein Timothy J. , Rubakhin Stanislav S. , Okyem Samuel , Croslow Seth W. , Asadian Marisa , Sabitha K.R. , Lazarov Orly , Lam Fan , Sweedler Jonathan V.
Published: November 2024

The progressive accumulation of amyloid beta (Aβ) plaques is a hallmark of Alzheimer’s disease (AD). However, the biochemical mechanisms of their formation and the consequences associated with plaque formation remain elusive. Changes in lipid compositions have been reported in AD using targeted mass spectrometry approaches and connected to neuroinflammation but provided limited spatial detail. We report here a new non-targeted approach for discovering and mapping region-specific, plaque-associated lipids including isomers. We accomplish this via a multimodal framework that integrates matrix assisted laser desorption/ionization with laser-induced postionization (MALDI-2) mass spectrometry imaging and trapped ion mobility spectrometry-based spatial lipidomics. Our approach integrates significantly enhanced detectability and spatial-chemical resolution, fluorescence microscopy, and a computational pipeline for multimodal image co-registration and untargeted discovery of plaque-altered lipids. Plaque-associated and brain-region-specific lipidomic changes with striking lipid heterogeneity among individual Aβ plaques across different regions were revealed, as well as unique spatial distributions of lipid isomers around Aβ plaques in a mouse AD model. This approach provides a new tool to enhance our understanding of the Aβ microenvironment.
Exploring the Influence of Approximations for Simulating Valence Excited X-ray Spectra
Authors: Penfold Thomas , Curchod Basile
Published: November 2024

First principles simulations of excited state X-ray spectra are becoming increasingly important to interpret the wealth of electronic and geometric information contained within femtosecond X-ray absorption spectra recorded at X-ray Free Electron Lasers (X-FELs). However, because the transition dipole matrix elements must be calculated between two excited states (i.e. the valence excited state and the final core-excited state arising from the initial valence excited state) of very different energies, this can be challenging and time-consuming to compute. Herein using two molecules, protonated formaldimine and cyclobutanone, we assess the ability of n-electron valence state perturbation theory (NEVPT2), equation-of-motion coupled cluster theory (EOM-CCSD), linear-response time-dependent density functional theory (LR-TDDFT) and the maximum overlap method (MOM) to describe excited state X-ray spectra. Our study focuses in particular on the behaviour of these methods away from the Franck-Condon geometry and in the vicinity of important topological features of excited-state potential energy surfaces, namely conical intersections. We demonstrate that the primary feature of excited state X-ray spectra is associated with the core electron filling the hole created by the initial valence excitation, a process that all the methods can capture. Higher-energy states are generally weaker and more sensitive to the nature of the reference electronic wavefunction. As molecular structures evolve away from the Franck-Condon geometry, changes in the spectral shape closely follow the underlying valence excitation, highlighting the importance of accurately describing the initial valence excitation to simulate the excited state X-ray absorption spectra.
AI-driven drug discovery: identification and optimization of ALDH3A1 selective inhibitors with nanomolar activity
Authors: Jain Sankalp , Yasgar Adam , Dalal Anu , Davies Marissa , Nilova Aleksandra , Martinez Natalia , Simeonov Anton , Rai Ganesha , Zakharov Alexey
Published: November 2024

In the field of medicinal chemistry, the discovery of novel compounds with therapeutic potential is of utmost importance. However, the conventional approach to drug discovery, relying on high-throughput screening (HTS), encounters limitations such as reagent availability and labor costs. Although a hit-finding campaign starts with a virtual screen of millions of compounds, the hit-to-lead and lead optimization stages often require designing, synthesizing, and profiling thousands of analogs before selecting clinical candidates. Recent advances offer an innovative solution - the virtual generation of billions of synthetically feasible compounds with an impressive 80% success rate for synthesis. This breakthrough has the potential to significantly expand the chemical space available for purchase and experimental validation, bringing about a revolution in the field. Our study presents a comprehensive approach to compound discovery and optimization, harnessing quantitative high-throughput screening (qHTS), chemical databases, and reaction-based enumeration. To further enhance the synthesis process and gain deeper insights into compound formation, we utilize the Reaction Cookbook from Biosolveit, which comprises reaction SMARTs for around 300 chemical reactions. By employing this wide range of reactions, we aim to uncover the full spectrum of a chemotype's potential and customize its structure to optimize desired properties. As an illustration of this approach, our work on the ALDH3A1 project resulted in the synthesis of 50 compounds, with 21 of them exhibiting activity (negative curve class values; hit-rate ~42%). Among these active compounds, 6 displayed IC50 values lower than 30 µM and efficacy values less than -50%, with the most potent compound achieving an impressive potency of 35 nM. This study demonstrates the successful synergy between in-silico reaction-based analogs enumeration, molecular modeling and AI/ML-based techniques in identifying compounds with improved biological activity, offering promising prospects for the development of ALDH3A1-targeting agents as potential cancer therapeutics. Computational workflows developed in this study can be used for similar target-based drug discovery campaigns.
Unlocking the flexibility of multi-material 3D extrusion printing for soft iontronics
Authors: Kalkus Trevor , Unterreiner Tamara V. , Schmidt Målin , Wächter Laura D. , Schmitt Christina R. , Mishra Ankit , Selhuber-Unkel Christine
Published: November 2024

Iontronics can improve wearable devices, implantable devices, and environmental sensors by replacing traditional rigid electronics with viscoelastic materials that mimic biological tissue. Circuit components, including diodes, transistors, and power sources, have been fabricated with soft materials that utilize ionic current instead of metals and electronic current. However, the fabrication of these iontronic components can be tedious, and widely applicable manufacturing methods are lacking, thus hindering the development of complex iontronic circuits for real-world applications. While 3D printing has recently gained popularity due to its versatility, we suggest that it has been underutilized for iontronics. By combining multi-material 3D printing and iontronics, we show the ability to rapidly iterate ionic diode design and integrate these diodes within a complex structure with advanced mechanical behavior. With an updated 3D model design, we create a new stretchable diode that is insensitive to strain, a feature that can be crucial for applications requiring soft electronics. To further emphasize the adaptability of printing soft materials, we demonstrate that three components of the based ink (conductive polymers, a thickening agent, and a crosslinker) can be used to optimize print quality and the resulting material properties. In doing so, we thoroughly characterize a mixed ionic-electronic conducing ink using poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) that can provide a foundation for the further development of extrusion printed iontronics. Compared to previously established methods, multi-material printing reduces cost, wasted material, and time required to develop complex devices in a manner that can be personized as well as highly reproducible.
Impact of charging in constant potential electrochemistry modeling
Authors: Kristoffersen Henrik
Published: November 2024

A huge issue in computational electrochemistry is that different modeling approaches, used to study electron transfer reactions, give different results and cannot easily be reconciled with each other. One discrepancy is their handling of interface charging. I study charging of electrolyte-Cu(111) interfaces with electrons and cations (or positive continuum charge) and observe that the charging energy depends strongly on the electrolyte model. When the electrolyte is a film containing water and KOH ions, there is a close to one-to-one stabilization (1 eV/V) of the energy with more negative potential, which fits with an ideal charging behavior, where the inserted electron-cation pairs do not repel each other. This is in strong contrast to the charging of an interface with implicit solvent, where the lack of electric-field screening result in large repulsion, which could give the erroneous impression that charging can be ignored in electrochemistry modeling. I further consider constant potential CO2 adsorption to highlight the importance of charging and using an electrolyte model with water and ions, and show that other modeling approaches gives significantly different and less stable CO2 adsorption energies.
Predicting Emission Wavelengths and Quantum Yields of Diverse Bis-cyclometalated Iridium(III) Complexes Using Machine Learning
Authors: Tatarin Sergei , Krasnov Lev , Nykhrikova Ekaterina , Minin Maxim , Smirnov Daniil , Churakov Andrei , Bezzubov Stanislav
Published: November 2024

Cyclometalated iridium(III) complexes are excellent emitters for phosphorescent organic light-emitting diodes, but the design of such complexes require substantial cost and experimental efforts. In turn, the predictive power of density functional theory calculations is seldom enough for reliable prediction of the excited state properties of iridium(III) complexes. In this work, we aimed at data-driven prediction of the emission energies and photoluminescence quantum yields of such complexes. To this end, we created a database (IrLumDB) that contains experimentally measured luminescence properties for over 1200 literature bis-cyclometalated iridium(III) complexes. Based on this database, we developed machine learning models that are capable of predicting the energy of emission maxima and photoluminescence quantum yields for the iridium phosphors with mean absolute errors of 18.26 nm and 0.129, respectively, requiring only SMILES of ligands. Furthermore, we validated the model for emission wavelength prediction on the set of 33 experimentally obtained luminescence spectra for newly synthesized and characterized iridium(III) complexes. Our data-driven methodology will complement quantum chemical calculations as an efficient alternative approach for the prediction of the excited-state properties of large sets of bis-cyclometalated iridium(III) complexes, facilitating computational discovery of efficient emitters. The emission properties prediction and the dataset exploration are available at https://irlumdb.streamlit.app/.
Beyond Butler-Volmer equation for CO2 electro-reduction on Cu-based gas diffusion electrodes
Authors: Adesina Peace , Ager Joel , Lapkin Alexei
Published: November 2024

We present a methodology for modelling gas diffusion electrodes with Cu-based catalysts. The applicability of the Butler Volmer equation (B-Ve) based on Tafel analysis is limited to single electron transfer reactions which are not typical of CO2 reduction reactions on Cu catalysts. We developed a method that involves linking the nanoscale effects encapsulated in a detailed calibrated microkinetic model (MKM) on Cu(100) electrodes to a mass transport model (MTM) on a low surface area, flooded agglomerate electrode. The MKM carries richer kinetic information of most reaction pathways described in contemporary literature for Cu(100). Polynomial equations are used to bridge kinetic and transport models without the need for excessive complexity. Our results show that using regression modelling, the microkinetic information at the microscopic level of the catalyst can be successfully linked with the macroscopic electrode models. We observe how mass transport parameters such as CO2 concentration, pH, and applied voltage, interacts with microkinetic information of the catalyst, influencing the reaction pathways and current densities of key products methane, ethylene, ethanol, and hydrogen. Although the model explores the medium to high voltage regimes, the methodology can address the oversimplification of CO2 reduction (CO2RR) kinetics and hydrogen evolution reaction (HER) for observed multiple kinetic regimes if comprehensive microkinetic models are integrated. It also serves as a foundational work for further experimental endeavours for the development of comprehensive microkinetic models. The holistic approach carried out in this work allows for the optimization of both reaction rates and mass transport, paving the way for rational optimisation of electrode designs and their scaling towards commercialization.
Towards Digital Twin of an In-situ Experiment: A Physics-enhanced Machine-Learning Framework for Inverse Modelling of Mass Transport Processes
Authors: Peng Haonan , Rajyaguru Ashish , Curti Enzo , Grolimund Daniel , Churakov Sergey , Prasianakis Nikolaos
Published: November 2024

As a prove of concept for experimental geochemistry, an advanced 3D numerical framework, here and after called Digital Twin (DT), of a diffusion experiment conducted at a synchrotron beamline, has been implemented using in-situ measurements data, physics-based modelling, a machine learning (ML) model, and parameter optimization module. The physics-based model enables finely discretized high-resolution 3D mass transport simulations, which provide the training set for the ML model. The resulting ML model greatly accelerates the computationally intensive calculations needed for the interpretation of the experimental observations during inverse modelling. The framework is applied to interpret the in-situ non-destructive micro-X-ray fluorescence (u-XRF) imaging data from a bromide diffusion experiment through a silica-gel-filled capillary system. The computational framework is refined, and several optimization algorithms are implemented to fit the experimental data. The gain in computational efficiency allows modelling the experiment practically in real-time.
Poly(imidazoyl)-Albumin Nanocarrier Responding to Two Metabolic States of Glycolytic Tumors for Targeted and Traceless Drug Delivery
Authors: Schauenburg Dominik , Schueler Darijan , Gao Bingjie , Zoppelt Jan Michael , Foerch Lisa , Moscariello Pierpaolo , Kuan Seah Ling , Weil Tanja
Published: November 2024

Altered cellular metabolism is a hallmark of cancer progression, often leading to a chemical microenvironment of solid tumors (TME) that reveals significant differences from that of normal cells. Nanotherapeutics capable of detecting distinctive chemical signals within the disparate metabolic states of invasive cancer phenotypes represents a promising avenue for eliciting a favourable anti-tumor response, thereby enhancing drug efficacy and safety through microenvironment-selective cellular uptake and intracellular release. For instance, triple-negative breast cancer (TNBC), which is notoriously difficult to treat, typically features extracellular acidification and elevated intracellular glutathione (GSH) levels. By leveraging these distinctive metabolic characteristics, we have developed a surface-modified translational human serum albumin (HSA) nanocarrier, termed His-aHSA, which features anionic carboxylic acid and pH-inducible positively charged imidazole groups. This modification endows the nanocarrier with the ability to perceive the acidic TME, responding to a pH change typical for glycolytic, lactate producing tumors, which enables selective uptake into TNBC cells and spheroids. Notably, the nanocarrier His66-aHSA demonstrated a substantial increase in uptake at pH 6.5 of invasive TNBC in comparison to the pH relevant for normal tissue (pH 7.4). Furthermore, the clinically approved chemotherapeutic agent gemcitabine was conjugated via a self-immolative, redox-sensitive linker that responds to the high GSH levels typical of TNBC cancer cells and spheroids, thereby achieving a controlled and traceless intracellular drug release. It is notable that the traceless cleavable analogue (Gem-SS-His66-aHSA) exhibits a comparable IC₅₀ value of 6.1 nM, similar to that of the native drug (4.4 nM). Conversely, the non-cleavable analogue (Gem-His66-aHSA) displays an IC₅₀ that is over 10 times higher (74.6 nm).
Spark Ablation Generation of Metal Nanoparticles and Coating on TiO2 in the Aerosol Phase
Authors: Gfeller Benjamin , Becker Mariia , Bukowiecki Nicolas , Aebi Adrian Dario , Wyss Marcus , Kalberer Markus
Published: November 2024

Generation and characterisation of metal nanoparticles (NP) gained attention in recent years due to their significant potential in applications as diverse as catalysis, electronics or energy storage. Despite the high interest in NPs, their characterization is challenging and detailed quantitative information on size, number concentration and morphologies are key to understand their properties. In this study we generated NPs from four metals, Au, Pt, Cu and Ni, via spark ablation in the aerosol phase, which allows to produce NPs as small as 1 nm in high quantities and purity. Particles were characterised with transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDX) as well as online aerosol particle size distribution measurement techniques. Particle modes for the four metals ranged between 3 nm and 4 nm right after generation. The number and size of particles generated correlated with thermal properties of the metals such as thermal or electrical conductivity. The four metal NPs were also coagulated with larger TiO2 NPs of about 120 nm size and the metal surface coverage of the TiO2 particles was characterised with electron microscopy and EDX spectroscopy.
Activation of I2 with aryl iodine(III) for the iodination of deactivated arenes
Authors: Sceney Marcus , Choi Jade , Barwise Lachlan , _ Tania , Phillips Juliette , Dostinoska Katerina , Dutton Jason
Published: November 2024

A highly effective method for iodinating deactivated aryl rings is reported, using organic solvents (CH2Cl2, CHCl3) where traditional methods typically require concentrated H2SO4. A new aryl iodine(III) system oxidizes I2 in the presence of trifluoroacetic anhydride as a water scavenger and catalytic H2SO4 in cases of very deactivated rings. The aryl iodine(III) oxidants, 4-nitrophenyliodine bis(trifluoroacetate) (NPIFA), 3-iodosylbenzoic acid (3-IBA), or 2,4-dichloro-5-iodosylbenzoic acid (3-IBACl2) are applied based on separability and reactivity of target substrates, and their reduced forms are recovered by simple acid/base extractions, demonstrating excellent reusability. Leveraging this, iodinated products are isolated without the need for chromatography. The method is suitable for use under benchtop conditions, and exhibits high atom efficiency, fully incorporating I2 into products.
C-H Bond Activation by Sulfated Zirconium Oxide is Mediated by a Sulfur-Centered Lewis Superacid
Authors: Lakliang Yutthana , Kolganov Alexander , Groves Marc , Sydora Orson , Pidko Evgeny , Conley Matthew
Published: November 2024

Sulfated zirconium oxide (SZO) catalyzes the hydrogenolysis of isotactic polypropylene (iPP, Mn = 13.3 kDa, Đ = 2.4, = 94 %) or high-density polyethylene (HDPE, Mn = 2.5 kDa, Đ = 3.6) to branched alkane products. We propose that this reactivity is driven by the pyrosulfate sites SZO, which open under mild reaction conditions to transiently form adsorbed SO3 and sulfate groups. This adsorbed SO3 is a very strong Lewis acid that binds 15N-pyridine or tri-ethylphosphineoxide (TEPO) (Eads > –39 kcal mol-1), reacts with Ph3CH to form Ph3C+, and mediates H/D exchange in dihydroanthracene-d4. DFT studies show that pyrosulfate sites have a modest 26.1 kcal mol-1 barrier to form the adsorbed SO3 and sulfate in the presence of a tetramer of propylene. Hydride abstraction from the tertiary C–H in this model is exo-thermic and subsequent -scission forms cleaved products. Analysis of the energetics provided here brackets the hydride ion affinity (HIA) of the adsorbed SO3 between 226.2 to 237.9 kcal mol-1, among largest values reported for a Lewis acid. This study explains how SZO, a classic heterogeneous catalyst whose activity is often attributed to Brønsted acidity, can form carbocations by a redox neutral hydride abstraction reaction by very strong Lewis sites.
Malaysian Social Media Users and Empowerment through Social Surveillance
Authors: Jgin Jit Yvonne Hoh , Firdaus Amira Sariyati Binti
Published: November 2024

Introduction: Surveillance is traditionally associated with negative authoritative monitoring to control society and often viewed as invasion of state authority that disregarded citizens’ right to privacy. However, ongoing technological advancements in networked, mobile and digital technologies facilitate social transformations in surveillance. Users of digital technology can also engage in surveillance. This research explored Malaysian social media users’ awareness and perception of social surveillance and investigated the manner of which social surveillance was utilised.

Methods: Drawing upon a series of in-depth interviews conducted via Facebook messenger with a selected group of Malaysian social media users, this paper explored how Malaysians understand social media as a tool of surveillance and empowerment. Malaysians, being some of the most active users on social media platforms in the world were selected for this study.

Findings: Findings suggested that surveillance did not merely subject individuals to scrutiny but also offered opportunities for empowerment because of that scrutiny. Empowerment through social surveillance brought benefits to individual users and also encourages an expansion of surveillance activities. However, most do not perceive such conduct as surveillance because the interviewees viewed institutional surveillance as actual surveillance while social surveillance as a concept was foreign to them. 
Originality: Surveillance studies is still an emerging field in Southeast Asia and is rarely taught as an independent subject in Malaysia. This perspective of this research considered the use of surveillance as a tool for empowerment and this is not an area that is studied much in this part of the world.
Path and boundary-path groupoids of nonfinitely aligned higher-rank graphs over weakly quasi-lattice ordered groups
Authors:   , Jones Malcolm
Published: November 2024

Given a weakly quasi-lattice ordered group (Q, P) and a P-graph Λ (not necessarily finitely aligned), we construct a locally compact Hausdorff path space inside the space of filters in Λ. When Λ is finitely aligned, the path space coincides with the space of filters in Λ. We construct a semigroup action of P on the path space whose semidirect product groupoid is a Hausdorff ample groupoid. We call the semidirect product groupoid the path groupoid of Λ, which is in general distinct from the one that Spielberg associates to nonfinitely aligned left cancellative small categories. We show the path groupoid coincides with the Toeplitz groupoid of Renault--Williams and with the path groupoid of Yeend under each of their hypotheses. If Q is countable and amenable, then the path groupoid is amenable by a theorem of Renault--Williams. We also define a boundary-path space that is a closed invariant subset of the unit space of the path groupoid. The reduction of the path groupoid to the boundary-path space is the boundary-path groupoid of Λ, which too we reconcile with the relevant groupoids of Renault--Williams and Yeend. For a particular nonfinitely aligned P-graph, we show that our path groupoid and Spielberg's groupoid have C*-algebras with different ideal structures.
Nag Mohashoy Temple Complex, Narayanganj: A Case Study of Adaptive Reuse for Hindu Religious Site
Authors: Ahmed Sayed
Published: November 2024

With an emphasis on the religious component of reuse potentiality, this study investigates the crucial nexus between spatial development and the conservation model for religious practice with socio-communal dimensions. Adaptive reuse is a critical tactic for global preservation and revitalization to elevate heritage sites in culturally significant locations but provides contemporary functions to them simultaneously. This study examines the various facets of adaptive reuse concerning the religious cultural heritage of suppressed minorities, stressing its insight and importance including the inherent cultural worth of ancient structures and difficulties through creative solutions to modify the temple with modern purposes. The research methodology approaches through an extensive analysis of the literature and case studies and ends with design interventions. It looks into the socioeconomic advantages of adaptive reuse in religious practice, such as the promotion of pilgrimage tourism, community revitalization, and sustainable development. The possible findings will emphasize the conversation on sustainable heritage management by combining theoretical frameworks with practical discoveries as an architectural project with certain concepts.
Research on Intelligent Cost Estimation of Engineering Foundation Projects Based on CSIs Theory
Authors: Di Jie , Xing Wenhao , Wu Meng , Zhang Dan , Zhao Jiashuo
Published: November 2024

Against the backdrop of rapid development in China’s construction and infrastructure sectors, discrepancies between project budgets and actual costs have become pronounced, manifesting in project overruns and suspensions, posing significant challenges. To address inaccuracies in investment targets and operational complexities, this study focuses on a beam-bridge construction project in a district of Shijiazhuang city as a case study. Drawing upon historical analogs, the project employs a Work Breakdown Structure (WBS) to decompose the engineering works. Building on theories of Cost Significant (CS) and Whole Life Costing (WLC), the study constructs Cost Significant Items (CSIs) and develops a CNN-BiLSTM-Attention neural network for nonlinear prediction. By identifying significant cost drivers in engineering projects, this paper presents a streamlined cost estimation method that significantly reduces computational burdens, simplifies data collection processes, and optimizes data analysis and forecasting, thereby enhancing prediction accuracy. Finally, validation with real-world cost fluctuation data demonstrates minor errors, meeting predictive requirements across project execution phases.
Practice Exploration of Green Building Design in Prefabricated Residential Building Design
Authors: Yu Yonghui
Published: November 2024

Prefabricated residential building design fully embodies the concept of green building and aligns with China’s strategic plan for sustainable development. However, there is a need to further optimize green building design methods, enhance the design quality of prefabricated residential buildings, and improve energy and resource utilization. Compared to traditional construction methods, prefabricated residential building design still faces several challenges during the actual construction process. These challenges include difficulties in design, material selection and processing, and the high demands for construction coordination. To strengthen the application of green building concepts in prefabricated residential design and effectively promote the sustainable development of the construction industry, this paper discusses practical measures for implementing green building design in prefabricated residential projects for reference.
Seismic Performance of Prefabricated Continuous Girder Bridge
Authors: Xiong Hongyuan
Published: November 2024

Bearings are the weak link in the seismic design of bridges. Using a continuous girder bridge as an example, it is demonstrated that bearing damage should be considered under large earthquake conditions. The bearing, acting as a fuse-type unit, can be designed to be preferentially damaged to effectively control the displacement of the beam and the response at the base of the pier during an earthquake.
Philologist and editor Antonina Strutynska
The reconstructing of her biography
Authors: Drozdovska Olesia
Published: November 2024

The relevance of the research is due to the fact that there are still no studies dedicated to the complex life and multifaceted professional activities of Ukrainian philologist, bibliographer, educator, editor, and publicist Antonina Strutynska. The purpose of this paper is to reconstruct A. Strutynska’s life story based on archival documents, memoirs, and press publications, as well as to highlight her teaching, editorial, journalistic, and library activities, and to compile a list of discovered publications. Several specialized scientific methods were used to achieve these goals: heuristic and biographical methods significantly supplemented A. Strutynska’s biography with new facts; the comparative method helped to compare events and facts, forming a coherent chain of events; and the bibliographic method was used to compile a list of articles authored by her.

As a result of the study of the archival documents from the collections of the Sectoral State Archive of the Security Service of Ukraine, personnel files from the archives of the I. Krypyakevych Institute of Ukrainian Studies of the National Academy of Sciences of Ukraine and the Lviv National Musical Academy named after Mykola Lysenko, memoirs, and press publications allowed for filling in gaps in A. Strutynska’s biography and clarifying information about her teaching, research, journalistic, and bibliographic activities. The materials from surveillance and criminal cases, including protocols of searches, interrogations, court hearings, and court decisions, provided insights into the reasons and circumstances behind her arrest and demonstrated the cynicism of Soviet justice. The paper emphasizes that declassified documents, on the one hand, are the most comprehensive source for studying A. Strutynska’s life, and on the other, reveal the repressive mechanisms of punitive “justice” and tools of psychological pressure on arrested representatives of Ukrainian culture.

The scientific novelty is represented by the previously unknown pages of her life: family ties, details of her pedagogical and journalistic activities, arrest and stay in prison camps. Her cryptonyms were also uncovered, and a number of her authored materials introduced into scholarly circulation.
Overcoming alienation. Humanistic existentialism and expressionist technique in Ihor Kostetskyi’s prose
Part one
Authors: Vasylenko Vadym
Published: November 2024

The paper deals with the existentially significant problem of alienation in Ukrainian emigration literature and the ways of its artistic realisation in the prose of Ihor Kostetskyi of the second half of the 1940s (in particular, in such ‘extroverted’ experimental works such as The Train Stopped Every Now and Then, A Novella for You, We and Nedzh, The Poet and His Women, The Divine Lie, Six Lanterns and the Seventh Moon, The Story of the Last Match, each of which is based on a person in the system of his or her connections with the world and with oneself). This problem is considered in the context of humanistic existentialism as a certain type of the writer’s thinking and the ideological and worldview basis of his works, as well as through the prism of expressionist poetics of his fiction. The purpose of this study is to analyse the significance of the problem of alienation and the ways of its artistic embodiment in some prose works by I. Kostetskyi of the 1940s, and, accordingly, to expand the understanding of the existentialist basis of his prose thinking and expressionist technique of fiction writing. For this purpose, the article uses socio-cultural (to determine the theoretical aspects of the concept of alienation), biographical (to understand the relationship between the text and the author) and comparative (to clarify intertextual parallels and intertextuality) methods of analysis.

The scientific novelty of the study lies in its first-time exploration of a range of themes, images, and motifs in Kostetskyi’s prose of this period within the context of alienation, revealing the existentialist and expressionist aspects of his work. The analysis incorporates literary criticism and studies from Kostetskyi’s contemporaries (notably Yurii Sherekh, Volodymyr Derzhavyn, Viktor Petrov, Hryhorii Kostiuk, and Vasyl Barka) as well as current researches.

The result of the study is the conclusion that expressionism, as a dominant mode of artistic interpretation of the phenomenon of alienation, has influenced the imagery system, character development, narrative style, and is realized at various levels of aesthetic integrity in each work (problematic-thematic, plots-compositional, and temporal-spatial). The mechanisms of alienation’s emergence are examined as a result of the clash between the personal and the socially conditioned, as well as the disconnection between the individual and the world. Additionally, the paths to overcoming alienation and the artistic means that enable the writer to achieve their goals (including factors such as a language, play, mask, etc.) are analyzed.
“Letters from Paris” and “Letters from London” by Mykhailo Rudnytskyi in the press
Texts and contexts
Authors: Gabor Vasyl , Komarytsia Mariana
Published: November 2024

The research problem of this article is the ways of rethinking the knowledge of the foreign world in the context of the realities of one’s own homeland and the definition of the vision of a foreign land that is embodied in an actual work of art. The object of the study is the essays of the leading Galician critic Mykhailo Rudnytskyi, framed in the form of an epistolary genre and published in the pages of the Lviv daily Dilo and the emigration magazine Volia in the interwar period. The purpose of the article is to clarify the representative forms of depicting two European cultures in the context of the author’s worldview through the prism of the cycles of press publications Letters from Paris and Letters from London by Mykhailo Rudnytskyi, their formal, stylistic and thematic features, and the reasons for their wide resonance in the Galician interwar press. The main method of the study was comparative analysis, which involved a comparison between the socio-political and artistic life of France and Great Britain, centred in the capitals of these countries, and the Ukrainian realities of the time.

The study has shown that M. Rudnytskyi developed the popular genre of travel essay, giving it an epistolary form and a peculiar author’s flavour. The subject matter of the Letters… covered a wide range of socio-political, cultural, artistic and everyday life in Paris and London, which were often interpreted in comparison with Ukrainian realities. The author’s reflections on iconic cultural institutions and artistic phenomena demonstrate an attempt to find ways to ‘fit’ Ukraine into the pan-European context. The critic’s reports from the French and British capitals contributed to a deeper understanding of life in France and England; the characteristic stylistic features of M. Rudnytskyi’s publications were irony and sarcasm, paradox, aphorism, provocativeness, which significantly expanded the existing boundaries of genres and formed the author’s bright and recognisable style. Letters… caused a significant resonance and became an incentive for similar publications by other writers and publicists.
Posttravmatik Stress Pozuntusunun Diaqnostika Və Müalicəsi
Authors: smayılov F. İ
Published: November 2024

PTSP və streslə bağlı olan digər pozuntular bilavasitə əlverişsiz və ya travmatik hadisə və ya hadisələr seriyasının təsirilə yaranır. Pozuntuların hər birində stress amilinin olması mütləq, lakin kifayət etməyən şərtdir.
Streslə üzləşən insanların bir çoxunda psixi pozuntu yaranmır. Bəzi stress amilləri gündəlik həyatdakı əlverişsiz hadisələr (boşanma, işsizlik, maddi çətinlik, qohumunun ölümü) ilə bağlıdır. Digərləri isə həyat üçün təhlükəli və təbiətinə görə travmatik (bədbəxt hadisə, təbii fəlakət, zorakılıq, hərbi əməliyyatlar) ola bilər.
Hanefî Fakih Bişr b. Velîd el-Kindî (Ö.238/853) ve Hadis Rivayetleri Üzerine Bir Değerlendirme
Authors: Bulgurcu Kahraman
Published: November 2024

Ebû Hanîfe’nin (öl. 150/767) ve Hanefîlerin hadiste zayıf olduğu ve hadise gereken önemi vermedikleri iddiası Hanefî âlimlere karşı zaman zaman yapılmaktadır. Ebû Hanîfe ile talebelerinin hadis rivayetleri bu tür ithamlara karşı bir cevap olarak değerlendirilebilir. Hanefi mezhebinin görüşlerini belirleyen kurucu isimlerinden Ebû Yûsuf’un (öl. 182/798) talebesi olan Hanefî âlimi Bişr b. Velîd el-Kindî’nin (öl. 238/853) rivayet ettiği hadisler de bu cevaplardan biridir. Bişr b. Velîd, ilim geleneğine uygun olarak hadis öğrenmiş ve rivayet etmiş Hanefî bir âlimdir. Hanefî âlimlerin hadise ve hadis rivayetine gerekli önemi vermediğiyle ilgili iddialara Bişr’in rivayetleri ve bu konudaki gayretleri kanaatimizce cevap olacak niteliktedir. Bişr’in naklettiği hadislerin ve hadis râvisi olarak kimliğinin incelenmesine dair bir çalışma tespit edilememiş, bu sebeple rivayetlerinin toplanarak değerlendirilmesinin Hanefîlerin hadis ilmine hizmeti açısından faydalı olacağı düşünülmüştür.
Bişr’in naklettiği rivayetler Kütüb-i Sitte dışındaki bazı hadis kitaplarında geçmektedir. Bu araştırmada Bişr’in hicrî üçüncü ve dördüncü asırda telif edilen on üç hadis kitabında yer alan, 36 farklı hocadan aldığı 148 rivayeti kaynak, isnad ve muhteva bakımından incelenmiştir. Bişr’in naklettiği rivayetlerin 136’sı merfû, onu mevkuf ve ikisi ise maktû hadisten oluşmaktadır. Merfû rivayetler konularına göre incelendiğinde Bişr’in naklettiği rivayetlerin yaklaşık üçte ikisinin ahkâm konularıyla ilgili olduğu anlaşılmaktadır. Onun ahkâm konularıyla ilgili rivayetlerinin çok olmasında fakih olması önemli bir etkendir. Yine algıda seçicilik yönüyle bu tür rivayetlere daha çok önem verdiği anlaşılmaktadır. Bişr’in rivayetlerinin geçtiği kitaplardaki hadislerin çok azı mükerrer rivayetlerden oluşmaktadır. Asıl alanı fıkıh olan Bişr b. Velîd, bir hadisçi kadar olmasa da hadisle iştigal etmiş ve hadis rivayetinde bulunmuştur.
Weights of Codewords in Random Binary Linear Codes and Their Correlation Properties
Authors: Özen İbrahim
Published: November 2024

A classical problem in coding theory addresses moments of the weight spectrum distribution. The results in this work are on the weight moments of individual codewords rather than the weight spectrum. The expectations of single and pairwise products of weights of nonzero words in a random binary linear code are given. We show that the covariance between the weights of any pair of distinct nonzero words is zero. Our main theorem has an application to sequence correlations problem. We prove that the sums of out of phase self correlations, as well as sums of cross-correlations, of nonzero words in a random binary linear code are equal to zero.
La inclusión educativa en la educación superior. Reflexiones a partir del seguimiento de casos.
Authors: Galván Ávila Susana , Herrera Rodríguez Jacobo , Gemignani Alaffita Luz Angélica
Published: November 2024

Esta investigación aborda un tema crucial en el ámbito de la educación superior, en especial en el contexto de estudiantes que enfrentan barreras para el aprendizaje y participación (BAP). Para alcanzar las reflexiones expuestas se utilizaron guías de observación comportamental alineadas con los objetivos del estudio. La metodología que se empleó fue una variante del método de estudio de casos con técnicas descriptivas. Se documentaron factores que afectan la inclusión como prácticas docentes, ambiente del aula y políticas institucionales, proporcionando una visión detallada del contexto educativo. Se realizó el análisis de tres estudiantes universitarios con dificultades severas de aprendizaje, conducta o comunicación, garantizando el anonimato y la participación voluntaria mediante documentación formal. La integración de estudiantes que enfrentan BAP debe ser planificada y fundamentada, evitando la inclusión discursiva que puede resultar en exclusión. La educación específica y la capacitación docente son cruciales para abordar de forma adecuada las necesidades individuales. Los hallazgos coinciden con estudios previos sobre las dificultades en la prosecución académica y la necesidad de herramientas especializadas para mejorar la inclusión educativa.
Análisis bibliométrico de las variables innovación y contabilidad: en busca de una relación.
Authors: Solis Vázquez Sheila Yazmína , Azuela Flores Cristabell , Lara Treviño José Iván
Published: November 2024

Innovación y contabilidad son variables que ayudan a responder a los cambios relacionados con las tecnologías de la información y comunicación. Así, el propósito de este estudio consiste en determinar las tendencias en investigación sobre innovación y contabilidad. Para lo cual, se realizó un análisis bibliométrico aplicando la base de datos Scopus en el período de 1971 a 2023.  Con base a los hallazgos, se encontró que la revista que más investiga sobre estas variables es Management Accounting Research.  Carlsoon-Wall y Kraus son los autores que más han estudiado dichos constructos, y las instituciones que fomentan este tipo de investigaciones son Copenhagen Business School y University of Aveiro, ubicadas en Estados Unidos.  La principal aportación radica en que no se había realizado un estudio bibliométrico de estos constructos por lo que se considera un tema emergente. Además, es un tema de estudio que empieza a despertar la atención en la investigación, lo cual se observa con el incremento de publicaciones, teniendo un repunte en el 2020.  Finalmente, como futura línea de investigación se propone un estudio bibliométrico de innovación, contabilidad y sustentabilidad debido a que no existe una investigación anterior y sería de ayuda para las empresas.
CONSUMER ATTITUDE TOWARDS ECO-FRIENDLY PRODUCTS WITH SPECIAL REFERENCE TO TRIVANDRUM CITY
Authors: Sajeena H. , Azhakeswari S.A. Deepa
Published: November 2024

In the current scenario, understanding the attitude of customers towards eco-friendly products holds immense importance due to the rise of eco conscious consumerisms particularly among the younger generation, where ethical and environment consideration play a major role in their purchasing decision. As consumers increasingly realise the importance of eco product, the marketers are also seeking to promote sustainability. So the present study was conducted with the primary focus on analysis of consumer attitude towards eco-friendly products among the consumers. A sample of 250 respondents from Trivandrum city was selected by purposive sampling technique and analysed with the help of statistical tools such as percentage analysis, Chi-square test and Garrett’s ranking technique.  The findings of the study help the marketers to adapt strategies to meet evolving consumer expectations, promotes sustainable consumption pattern based on consumer attitudes, contributes broader environmental objectives and fosters a more responsible and eco conscious future.
Púrpura fulminans secundaria a meningococcemia con desenlace fatal: Reporte de caso y revisión de la literatura
Authors: Orozco Jiménez Sara , Agudelo-Rojas Olga Lucía , Mejía-Giraldo Ana María , Arciniegas-Grisales Valeria
Published: November 2024

La púrpura fulminante (PF) es una presentación infrecuente de la meningococcemia secundaria a trombosis intravascular e infarto hemorrágico cutáneo. Su curso es potencialmente letal, con tasas de mortalidad en la fase aguda entre 18-40%. Afecta con mayor frecuencia a lactantes, donde los casos en adultos se limitan a reportes de la literatura.
Presentamos el caso de un paciente con meningococcemia asociado a púrpura fulminante que requirió de amputación transtibial bilateral más amputación de las falanges distales de ambas manos.
La púrpura fulminante (PF) es una presentación infrecuente de la meningococcemia secundaria a trombosis intravascular e infarto hemorrágico cutáneo. Su curso es potencialmente letal, con tasas de mortalidad en la fase aguda entre 18-40%. Afecta con mayor frecuencia a lactantes, donde los casos en adultos se limitan a reportes de la literatura.
Presentamos el caso de un paciente con meningococcemia asociado a púrpura fulminante que requirió de amputación transtibial bilateral más amputación de las falanges distales de ambas manos.
Retroniquia: otra cara de la paroniquia crónica
Authors: Botello Mojica Heliana Marcela , Blanco Gomez Jennipher Andrea , Triana Veca Diana María , Hoyos Zuluaga Ana Maria
Published: November 2024

La retroniquia es una condición poco conocida caracterizada por el compromiso de la lámina ungueal proximal con enclavamiento de la misma, inflamación del pliegue, aparición de tejido de granulación y presencia de láminas ungueales superpuestas que van engrosando la parte proximal de la misma e interrumpen su crecimiento. Es más frecuente en mujeres jóvenes, alrededor de los 25 años, asociándose con traumatismos crónicos repetidos y uso de calzado inadecuado. El tratamiento de elección es la avulsión total de la lámina ungueal. Aun cuando es una causa de paroniquia crónica, su diagnóstico no se realiza siempre de forma oportuna constituyendo un reto en la práctica clínica.
Estudio observacional por medio de encuesta a dermatólogos en Colombia: diagnóstico y tratamientos de preferencia en pacientes con dermatitis atópica
Authors: Cardona Salazar Marcela , Cortés-Correa Carolina Ivette , Peñaranda Elkin , Castellanos-Lorduy Héctor José
Published: November 2024

Introducción: la dermatitis atópica es una enfermedad inmunomediada cada vez más estudiada. El objetivo de este estudio es identificar los criterios diagnósticos, las escalas de clinimetría, los tratamientos de preferencia. Además, las causas de elección y cambio de terapia y el tiempo de espera para ver la respuesta terapéutica.
Metodología: es un estudio observacional, descriptivo de corte transversal. Se hizo por medio de una encuesta virtual distribuida durante actividades académicas, previa realización de prueba piloto.
Resultados: se encuestaron 68 dermatólogos, el 29.3% basa el diagnóstico según la clínica, seguido de los criterios de Hanifin y Rajka (23.08%). Las escalas clínimétricas más usadas son DLQI, EASI, y valoración clínica (29.85%). La primera línea terapéutica para la enfermedad leve son corticoesteroides de mediana potencia (52.31%). En segunda línea prefieren cambio de potencia del corticoesteroide (38.46%). Las principales causas de iniciar terapia sistémica son: 1. la clínica severa y 2. alteración severa de la calidad de vida. Para elegir terapia sistémica se tiene en cuenta la severidad clínica y la eficacia del medicamento según literatura. En la DA moderada-severa la primera opción es fototerapia (59.38%) y corticoesteroides sistémicos (25%). Como segunda opción ciclosporina (25%), fototerapia (18.75%), azatioprina (18.75%). 
Conclusiones: es el primer estudio en Latinoamérica al respecto. Se encontró que no hay consenso sobre el diagnóstico y manejo de la enfermedad. En algunos casos no se está esperando el tiempo necesario para ver una respuesta clínica. Aporta información única sobre el tratamiento de dermatitis atópica y sugiere realizar actividades académicas para unificar conceptos entre especialistas.