bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational Thinking Analysis of 21st Century Professional Teacher Candidates In Solving Math Problems Viewed from The Four Foundations of CT
Authors: Aziz Saddam Al , Fauzan Ahmad , Helma Helma
Published: January 2024

Computational Thinking (CT) is a further development which is the latest innovation in mathematical problem-solving skills. Four foundations of CT make it easier for someone to solve problems effectively, efficiently, and optimally. This mixed methods research with an embedded design. Quantitative data were collected using tests and qualitative data through written interviews and an overview of the prospective teacher's thought processes in answering tests. The sample that became the research subject was selected using the purposive sampling method by selecting 28 pre-service teacher's mathematics in Professional Teacher Education (PTE) who attended CT lectures. The object of this research is the 4 CT foundations of prospective teachers in solving math problems. This study describes how CT skills solve problems. The test results show that the percentage of correct answers for each of the four CT foundations is more than 80%. It can be concluded that the knowledge and understanding of Computational Thinking for 21st-century professional teacher candidates in terms of 4 CT foundations are categorized as "very high". Based on the description of the student's answers, it was also concluded that the CT foundation is indeed the basis for thought processes in solving problems. It is the advantage of Computational Thinking.
The Use of Learning Media "Fun Physics Learning” Based on Android to Improve Problem-Solving Skills of Students
Authors: Isnaeni Putri Atika Diah , Septiyanto Rahmat Firman , Saefullah Asep
Published: January 2024

The research is motivated by the low problem-solving skills of students in learning physics. This study aims to determine whether there is no increase in the effectiveness of using Android-based learning media “Fun Physics Learning” on students' problem-solving skills. This type of research used a quasi-experimental design with a non-equivalent control group design. The population used was all students of class X SMAS Mandiri Balaraja, while the research sample used two classes, class X for the experimental class and the control class. The instrument used is a test in the form of an essay, which the validator and student response sheets have validated to the Physics Scatter application. Data analysis showed that there was a significant increase in the results of students' problem-solving skills, which were shown in the pretest and post-test of the experimental class, where there was a significant increase in the N-Gain acquisition of 0.61 in the medium category. Based on the hypothesis test using the t-independent sample test, obtained t-count = 11.002 and t-table = 2.045 at a significant level of 0.05 and got a positive student response. It was concluded that using Android-based Physics Spread learning media can improve students' problem-solving skills and is effectively used in learning.
Meta-Analysis of the Influence of the Inquiry Model on Student Learning Outcomes
Authors: MIKE YONIRA , Asrizal Asrizal
Published: January 2024

Student success in learning is very necessary to see the extent to which students are able to solve problems. However, it turns out that student learning outcomes are still low. The solution to overcome this problem is to apply the inquiry learning model during learning. This research aims to determine the effect of the inquiry learning model on student learning outcomes. The application of the inquiry model is seen from the level of education and physics and science lessons. This type of research is meta-analysis. Meta-analysis is research carried out by summarizing research data, reviewing and analyzing research data from several previously existing research results. This research article consists of 11 articles that have ISSN. The instruments used are category codes and effect size calculations. The steps of meta-analysis are conducting a literature review, collecting data, researching and assessing articles, analyzing and interpreting articles, and compiling report results. The data analysis technique in this research is to calculate the magnitude of the effect using a formula based on the mean. From the data analysis carried out, two research results can be stated. First, the application of the inquiry learning model has a significant effect on the level of education and subject matter, especially physics and science.
Meta-Analysis: The Effect of Learning Models on Students' Scientific Literacy
Authors: Nici Jumatul FItri Nici , Kartika Puput , Lutfiana Gita
Published: January 2024

In the 21st century, where technology and science are developing rapidly, scientific literacy is very important. Technology and scientific literacy in particular can help improve the quality of a country's education. By collecting 20 research results, this meta-analysis research aims to summarize research findings regarding the influence of learning models on students' scientific literacy abilities. This research aims to find out: the average effect size (ES) of which type of learning model has the largest effect size at the level of education, and which learning model has the most influence on students' scientific literacy. The results of the research show that the average ES is 1.21, which shows that the use of learning models has a significant impact on students' scientific literacy. The type of learning model most often used to increase students' scientific literacy is the Problem-Based Learning model with an average ES of 1.28. The Problem-Based Learning model is more influential at the high school education level with an average ES of 1.58 and on science material of 1.30 with an effect size in the high category.
LEARNING STYLES AND LEARNING OUTCOMES AMONG UNDERGRADUATE STUDENTS OF THE UNIVERSITY OF ILORIN COLLEGE OF HEALTH SCIENCES
Authors: Jaji-Sulaimon Rukayat
Published: January 2024

Background: For effective teaching and instructional design, it is essential to comprehend students' learning styles and how they relate to learning outcomes. Aim: With an emphasis on learning outcomes in the context of anatomy instruction, this study sought to identify several learning styles among undergraduate students in the College of Health Sciences, University of Ilorin. Methodology: A descriptive crosssectional survey was carried out among undergraduate students registered in the College of Health Sciences, University of Ilorin, Nigeria. The participants were chosen by a random sampling technique, yielding a sample size of 170 students with ages ranging from 18 to 25 years. To determine the students' preferences for visual, auditory, and kinesthetic (VAK) learning, a learning style questionnaire was given to them. The Chi-square test and other descriptive statistics were used to analyze the association between learning styles and learning outcomes. Result: According to this study's findings, students' chosen learning styles had little bearing on the knowledge they retained.Additionally, it was shown that undergraduateAnatomy students had a strong preference for the visual learning approach, although Nursing and Medical Laboratory Science (MLS) students did not. Also, no correlation between learning styles, gender, or the combination of learning styles and gender with academic accomplishment was discovered. Conclusion: It was concluded that using the VAK model assessment of learning styles, no significant relationship exist between learning styles and learning outcomes of students who took anatomy courses in the University of Ilorin.
UTILITY OF P63 IMMUNO-EXPRESSION IN DISTINGUISHING BENIGN MIMICKER LESIONS FROM ADENOCARCINOMA PROSTATE-AN OBSERVATIONAL ANALYTICAL STUDY
Authors: Tandon Dr. Pradeep
Published: January 2024

In men, prostate cancer (PCA) is the second most common malignancy and is the sixth leading cause of death amongst them. Differentiation of benign mimicker lesions (BML) of the prostate from PCA can be challenging sometimes, especially when limited amount of tissue is available. Several immuno-histochemical (IHC) markers are recommended for distinguishing such lesions; which becomes expensive for the patient. The present study was planned to study the utility of P63 IHC marker for diagnosis of benign, BML and adenocarcinoma of the prostate (ACP). The present - observational and analytical study - was conducted on 50 biopsy specimens of the prostate in the Department of Pathology at IIMSR, Lucknow during the period January 2017 to September 2022. The lesions included were: 20 specimens of benign prostatic hyperplasia (BPH), 17 of BML, 3 of prostatic intraepithelial neoplasia (PIN) and 10 of PCA. In the BML group, 5 specimens of basal cell hyperplasia (BCH), 4 specimens of simple atrophy (SA), 3 specimens of post atrophic hyperplasia (PAH) and 5 specimens of adenosis were studied. In the present study, all specimens of BPH and BML are positive for P63 expression on IHC staining. In the PIN group, 2 out of 3 specimens were positive for P63. All 10 specimens of adenocarcinoma prostate were negative for P63 expression. We conclude that use of P63 IHC staining is adequate for distinguishing benign and BMLof prostate fromACPin majority of the specimens.
MOLECULAR ADVANCEMENTS IN PROTEIN PHOSPHORYLATION METHODOLOGIES: A RAPID REVIEW
Authors: Lakkireddy Dr. Suresh
Published: January 2024

Phosphorylation, the reversible addition of phosphate groups to proteins, plays a pivotal role in regulating cellular processes, including signal transduction, cell cycle progression, and metabolism. Understanding the dynamics of phosphorylation events is crucial for unraveling complex signaling networks and identifying potential therapeutic targets in various diseases. Phosphorylation immunoassays have emerged as powerful tools for the detection and quantification of phosphorylated proteins, enabling researchers to gain insights into intricate cellular signaling pathways. This review provides an in-depth exploration of the recent advances, methodologies, and applications of phosphorylation immunoassays, highlighting their significance in advancing our understanding of cellular signaling.
CORTICOSTEROID OVERUSE AND UNINTENDED CONSEQUENCES IN CLINICAL PRACTICE
Authors: Farheen Dr. Zarina
Published: January 2024

Corticosteroids, heralded for their potent anti-inflammatory and immunosuppressive properties, have emerged as pivotal agents in the multifaceted landscape of medical therapeutics. While their efficacy in addressing an array of inflammatory conditions is well-established, the dynamic interplay between the therapeutic benefits and potential risks associated with corticosteroid use demands comprehensive examination. This expansive review delves into the intricate fabric of corticosteroid administration, unravelling the complexities of their mechanisms of action, broad-ranging indications, and the delicate equilibrium between therapeutic advantages and the potential for adverse effects. By scrutinizing the evolving evidence surrounding corticosteroid overuse, we strive to provide a comprehensive perspective on the medical, economic, and societal dimensions, advocating for a nuanced and balanced approach that maximizes the therapeutic potential of corticosteroids while minimizing the risks associated with their potential overuse.
COMPLEX WEB OF CARCINOGENS IN THE ENVIRONMENT: A COMPREHENSIVE REVIEW
Authors: Shahab Ariba
Published: January 2024

Cancer, a multifaceted and pervasive health concern, still ranks first in the globe for causes of morbidity and death. The environment in which individuals live and work plays a crucial role in the aetiology of cancer, with exposure to carcinogens contributing significantly to the risk. This review aims to synthesize existing evidence on environmental carcinogens, shedding light on their sources, distribution, and the associated risk of cancer development.
RECENT ADVANCEMENTS IN UNDERSTANDING THE GENESIS AND TREATMENT OF DERMATOPHYTOSIS: A COMPREHENSIVE OVERVIEW
Authors: Kumar Dr. Kislay
Published: January 2024

Tinea corporis is one of the most commonly fungal known illness resembling several different annular lesions. The usual presentation of tinea corporis is a well-defined, precisely outlined, circular or oval, scaly plaque or patch with slightly erythematous, with an elevated leading edge. Commonly, pruritus is mild. Although the prognosis is frequently clinical, it may be challenging if you've taken corticosteroids or calcineurin inhibitors in the past. A practical and noninvasive diagnostic method is dermoscopy. If required, microscopic analysis of KOH mounted wet preparations of scraped skin from the lesion's active border can be used to confirm the diagnosis. The most reliable method for diagnosing dermatophytosis is fungus culture, particularly when other test findings are unclear, the illness is severe, extensive, or resistant to therapy. Medical professionals need to get knowledgeable about this illness and how to treat it. The purpose of this paper was to present a narrative, up-to-date overview of tinea corporis examination, diagnosis, and therapy.
ROLE OF PROBIOTICS IN HUMAN HEALTH-A REVIEW
Authors: Fatima Ms. Kaynat
Published: January 2024

Over the last 20 years, probiotic bacteria have gained popularity because of the increasing number of scientific evidence supporting their positive impacts on human health. Probiotic products are widely present in the market, and their potential applications are expanding everyday due to the fact that certain probiotics strain support the quality of the gut microbiota. They have therefore been used in a variety of therapeutics, and the research has been actively ongoing. This review article focuses on probiotics' use in the management of various illnesses their action mechanism and health advantages.
TRUE KNOT OF UMBILICAL CORD PRESENTING WITH REDUCED FETAL MOVEMENTS - CASE REPORT
Authors: Nishad Dr. Suman
Published: January 2024

A 38 year old multigravida (gravida:4, para:2+1, live:1) with nonsevere pre-eclampsia presented at 34 weeks gestation with reduced fetal movements [RFM]. Admission cardiotocography was reactive. Obstetric ultrasound showed weight on 1st centile. Dopplers showed cerebroplacental ratio of 0.9 suggestive of brain sparing. Umbilical artery pulsatility index was at 96th centile, with forward flow in diastole. In view of the persistent complaint of RFM, it was jointly decided to expedite delivery of the fetus. Per operatively, a true knot was present around 10 cms from the umbilical end with blanching proximal to the knot. The baby was delivered active, with anApgar score of 6 and 7 at 1 and 5 minutes respectively.
NEAT1_1 long non-coding RNA reduces the survival of primary neuronal cells under ER-stress
Authors: Pukaeva NE , Zalevskaya VN , Deykin AV , Taubinskaya MI , Kukharskaya OA , Ovchinnikov RK , Antohin AI , Kukharsky MS
Published: January 2024

NEAT1 long non-coding RNAs play an important role in the central nervous system (CNS) and are associated with a number of pathological conditions. Increased levels of NEAT1 in the brain have been observed in neurodegenerative and psychiatric diseases — the significance of such an increase is still poorly understood. Functionally, NEAT1 is associated with cellular stress pathways in the nervous system. The aim of the current study was to evaluate the effect of increased levels of the short isoform NEAT1_1 on survival of mice primary hippocampal cultures under ER-stress induced by MG132 proteasome inhibitor. Primary cultures were obtained from transgenic animals expressing human NEAT1_1. Cellular composition and apoptosis were assessed using immunocytochemical staining. The expression of apoptosis signaling pathway genes was analyzed by quantitative PCR with reverse transcription. No differences in cellular composition and morphological characteristics of neurons were observed in primary neuronal cultures obtained from transgenic animals as compared to wild type cultures. Induction of ER-stress resulted in a more significant increase in apoptotic death of cells including neurons in NEAT1_1 expressing cultures in comparison with the wild type cultures. ER-stress signaling pathway genes Atf4 and Ddit3 were less expressed in transgenic cultures under stress. Expression of Bcl2l2 and Mcl1 anti-apoptotic genes was reduced as well. Thus, high levels of NEAT1_1 in primary neuronal cultures increased apoptotic cell death under ER-stress.
Impact of untranslated mRNA sequences on immunogenicity of mRNA vaccines against M. tuberculosis in mice
Authors: Shepelkova GS , Reshetnikov VV , Avdienko VG , Sheverev DV , Yeremeev VV , Ivanov RA
Published: January 2024

Vaccination is among the most effective measures to reduce tuberculosis morbidity and mortality. In 1974, BCG vaccination was included in the Expanded Program on Immunization. Today, it covers 80% of all children around the globe. Unfortunately, BCG vaccine provides no protection against pulmonary tuberculosis, the most prevalent form of tuberculosis. It is necessary to urgently develop new vaccination strategies to stop large-scale dissemination of infection caused by the multidrugresistant pathogen. The study was aimed to compare the capabilities of three variants of mRNA vaccines encoding Esat6 epitopes of stimulating adaptive immune response formation in C57BL/6 mice (ELISpot, delayed hypersensitivity, IgG titers), as well as of protecting I/St mice against M. tuberculosis infection. Efficacy of mRNA vaccines comprising different untranslated regions packaged in lipid nanoparticles was compared with that of BCG vaccine. The 5'-TPL-Esat6-3'-Mod vaccine demonstrated the highest efficacy in our experimental model. Thus, the 5'-TPL-Esat6-3'-Mod mRNA vaccine can be considered as a candidate vaccine for further optimization, improving efficacy and subsequent use for prevention of tuberculosis.
Foveal microsurgical reconstruction technique for macular hole
Authors: Takhchidi KhP
Published: January 2024

Macular rupture is among major vitreoretinal disorders resulting in significant visual function decline. In recent years, the use of platelet-rich autoplasma in the macular rupture surgery is considered to be promising. However, despite high rate of macular rupture closure (78–96%), the development of new technology for foveal microarchitectonics restoration and visual function improvement currently remains a pressing issue. The study was aimed to develop a new foveal reconstruction technique for macular rupture involving the use of autologous conditioned plasma. The reported study involved 9 patients (10 eyes) with idiopathic macular hole, who underwent standard three-port 27G vitrectomy involving the use of autologous conditioned plasma in accordance with the technique developed. The proposed technique makes it possible to achieve good clinical and functional surgical treatment outcome and ensures optimal and more manageable reconstruction of foveal microarchitectonics.
Altered circadian expression of cytokines in blood of patients with essential hypertension following COVID-19
Authors: Radaeva OA , Simbirtsev AS , Kostina YuA , Iskandiarova MS , Negodnova EV , Mashnina SV , Yeremeev VV , Krasnoglazova KA , Babushkin IO
Published: January 2024

In spite of a vast number of trials devoted to quantitative characteristics of the cytokine profile in patients with various diseases, no exact reference intervals are presented. It is just as important that there is a limited number of trials analyzing circadian rhythms of cytokine synthesis in patients with arterial hypertension. The purpose of the work was to analyze the characteristics of circadian rhythms of cytokines (IL18, IL18 BP, LIF, sLIFr, M-CSF, MCSFR) in patients with Grade II essential arterial hypertension, and to detect pathogenetically significant characteristics developed following Covid-19. Blood samples were taken at 7.00–8.00, 12.00–13.00, 19.00–20.00.00, 00.00–1.00 to determine the levels of IL18, IL18 BP, LIF, sLIFr, M-CSF, MCSFR in 18 patients (56 (95% CI (54–69) years) with essential arterial hypertension (EAH) within three days prior to and following Covid-19. For this, the immunoenzyme method was used. The obtained data demonstrated altered circadian expression of cytokines in the peripheral blood of patients with essential hypertension depending on whether they have EAH or not, and their additional distortion following Covid-19, which is stable in the majority of cases. It is preserved for six months as low IL18 BP (р < 0.001), and twofold increase of sLIFr and MCSF (р < 0,001) at 18.00. A significant association is determined between the circadian rhythms of sLIFr and altered systolic BP resulting in the abnormal rhythm with BP rise at night (night peaker) in patients with EAH following COVID-19. The obtained fundamental data offer prospects for new research of immunopathogenesis following COVID-19 in patients with hypertension taking into account circadian rhythms of cytokines in the blood.
Vliyanie netransliruemyh posledovatel'nostej mRNK na immunogennost' mRNK-vakcin protiv M. tuberculosis u myshej
Authors: Шепелькова Г. С. , Решетников В. В. , Авдиенко В. Г. , Шевырев Д. В. , Еремеев В. В. , Иванов Р. А.
Published: January 2024

Vakcinaciya yavlyaetsya odnim iz naibolee uspeshnyh medicinskih meropriyatij po snizheniyu zabolevaemosti i smertnosti ot tuberkuleza. V 1974 g. vakcinaciya BCZH byla vklyuchena v Rasshirennuyu programmu vakcinacii, i na segodnya ohvatyvaet 80% vsekh detej na zemnom share. K sozhaleniyu, vakcina BCZH ne zashchishchaet ot naibolee rasprostranennoj formy tuberkuleza — tuberkuleza legkih. Trebuetsya srochno razrabotat' novye strategii vakcinacii, chtoby ostanovit' shirokomasshtabnoe rasprostranenie infekcii s mnozhestvennoj lekarstvennoj ustojchivost'yu vozbuditelya. Cel'yu issledovaniya bylo sravnit' sposobnost' trekh variantov mRNK-vakcin, kodiruyushchih epitopy Esat6, stimulirovat' formirovanie adaptivnogo immuniteta u myshej C57BL/6 (ELISpot, GZT, titry IgG), a takzhe zashchishchat' myshej I/St ot zarazheniya M. tuberculosis. Effektivnost' upakovannyh v nanolipidnye chasticy mRNK-vakcin, razlichayushchihsya posledovatel'nostyami netransliruemyh regionov, sravnivali s effektivnost'yu BCZH. V poluchennoj nami eksperimental'noj modeli maksimal'nuyu effektivnost' po bol'shinstvu pokazatelej prodemonstrirovala vakcina 5'-TPL-Esat6- 3'-Mod. Takim obrazom, mRNK-vakcina 5'-TPL-Esat6-3'-Mod mozhet byt' rassmotrena v kachestve kandidatnoj dlya dal'nejshej optimizacii, povysheniya ee effektivnosti i posleduyushchego primeneniya dlya profilaktiki tuberkuleza.
Prognozirovanie iskhodov programm ekstrakorporal'nogo oplodotvoreniya s ispol'zovaniem modeli mashinnogo obucheniya «Sluchajnyj les»
Authors: Владимирский Г. М. , Журавлева М. А. , Дашиева А. Э. , Корнеева И. Е. , Назаренко Т. А.
Published: January 2024

Programmy ekstrakorporal'nogo oplodotvoreniya (EKO) s perenosom embrionov v nastoyashchee vremya yavlyayutsya osnovnymi metodami lecheniya vsekh form besplodiya, odnako uspeshnye sluchai, zakanchivayushchiesya nastupleniem beremennosti, po-prezhnemu sostavlyayut lish' tret' iz chisla vsekh provedennyh ciklov. Dlya ocenki rezul'tatov lecheniya besplodiya metodom EKO neobhodimo uchityvat' mnozhestvo pokazatelej i izuchat' vzaimosvyaz' mezhdu nimi. Za poslednie desyatiletiya byl razrabotan ryad modelej prognozirovaniya EKO dlya ocenki individual'nyh rezul'tatov lecheniya, no lish' nemnogie iz nih okazalis' klinicheski znachimymi, iz-za ih plohoj prognosticheskoj sposobnosti. Cel'yu issledovaniya bylo sozdat' nelinejnye modeli prognozirovaniya iskhodov EKO i vyyavit' naibolee znachimye faktory, vliyayushchie na rezul'tat lecheniya. Na osnove bazy dannyh, soderzhashchej informaciyu po bolee chem 700 pokazatelyam 7004 zhenshchin v vozraste ot 18 let do 45 let, proshedshih lechenie v programme EKO na territorii Rossijskoj Federacii s 2010 po 2020 g., byla obuchena model' «Sluchajnogo lesa», prognoziruyushchaya beremennost' v cikle EKO s ROC-AUC = 0,69. Opisany 20 samyh uspeshnyh prediktorov poluchennoj modeli s interpretaciej ih vklada v prognozirovanie. Iz nih indeks massy tela (IMT), chislo poluchennyh i oplodotvorivshihsya oocitov opisany v nauchnoj literature kak prediktory iskhoda programm EKO, v to vremya kak drugie priznaki, naprimer anamnesticheskie dannye, kolichestvo i iskhody predydushchih programm EKO, a takzhe syvorotochnaya koncentraciya AMG, redko figuriruyut v zarubezhnyh prognosticheskih modelyah.
Poluchenie rekombinantnogo ingibitora ribonukleaz v E. coli dlya ispol'zovaniya v sinteze mRNK in vitro
Authors: Захарова М. В. , Загоскин А. А. , Иванов Р. А. , Нагорных М. О.
Published: January 2024

Tekhnologii, lezhashchie v osnove polucheniya sinteticheskih mRNK in vitro, znachitel'no rasshirili vozmozhnosti ih issledovatel'skogo i terapevticheskogo primeneniya. Flagmanskoj oblast'yu primeneniya stala nisha mRNK-vakcin, odnako etot klass terapevticheskih molekul mozhet byt' primenim k gorazdo bolee shirokomu krugu zadach. V osnove processa polucheniya iskusstvennyh molekul RNK lezhit reakciya fermentativnogo sinteza in vitro, odnim iz komponentov kotoroj yavlyaetsya ingibitor ribonukleaz. Etot belok neobhodim dlya zashchity sintezirovannyh RNK ot atak ribonukleaz s cel'yu predotvrashcheniya degradacii molekul, chto kritichno dlya RNK. CHashche vsego ispol'zuyut ingibitor ribonukleaz eukarioticheskogo proiskhozhdeniya, poluchennyj v vide rekombinantnogo belka v kletkah bakterij E. coli. Odnako on yavlyaetsya slozhnoj mishen'yu dlya narabotki v bakteriyah, chto obuslovleno ego strukturoj. Cel'yu raboty bylo proverit' narabotku rekombinantnogo ingibitora ribonukleaz v razlichnyh shtammah E. coli, a takzhe pokazat' vliyanie helpernyh polipeptidov i kletochnyh shaperonov na etot process. Pri pomoshchi podhodov gennoj inzhenerii byli skonstruirovany plazmidy, s kotoryh provodili narabotku himernyh molekul ingibitora ribonukleaz i vspomogatel'nyh polipeptidov. Ocenku vklada razlichnyh komponentov, vliyayushchih na rastvorimost' celevogo rekombinantnogo belka, provodili v hode densitometricheskogo analiza rezul'tatov elektroforeza v PAAG. Opredelili, chto kombinacii vektora s sil'nym promotorom dlya ekspressii gena ingibitora ribonukleazy RNH1 i vspomogatel'nyh polipeptidov MBP i TIG na fone povyshennoj ekspressii kletochnyh shaperonov dnaK, dnaJ, grpE dayut vyhod celevogo produkta 45 mg/l i 60 mg/l sootvetstvenno. Podobrannye usloviya dayut vozmozhnost' krupnomasshtabnyh narabotok etogo belka dlya dal'nejshego ispol'zovaniya v sinteze RNK in vitro pri proizvodstve terapevticheskih preparatov.
Difficultés fonctionnelles chez les enfants et les jeunes atteints d’un trouble du spectre de l’autisme : une analyse de l’Enquête canadienne sur la santé des enfants et des jeunes de 2019
Authors: Farrow Amy , Al-Jaishi Ahmed A. , O’Donnell Siobhan , Palmeter Sarah , Georgiades Stelios , Chen Yun-Ju , McPhee Patrick G. , Edjoc Rojiemiahd
Published: January 2024

Introduction

Cette étude porte sur la prévalence des difficultés fonctionnelles et des facteurs connexes chez les enfants et les jeunes canadiens de 5 à 17 ans ayant reçu un diagnostic de trouble du spectre de l'autisme (TSA).

Méthodologie

Nous avons analysé les données tirées de l’Enquête canadienne sur la santé des enfants et des jeunes (ECSEJ) de 2019, une enquête nationale représentative de la population canadienne d’enfants et de jeunes, qui utilisait l’ensemble abrégé de questions sur le fonctionnement du Groupe de Washington (Washington Group Short Set on Functioning, WG-SS) pour évaluer le fonctionnement dans le cadre de six tâches quotidiennes. Pour chaque domaine fonctionnel, des résultats binaires ont été générés (aucune difficulté/quelques difficultés, beaucoup de difficultés/n’y parvient pas du tout). Nous avons ensuite utilisé une régression logistique pour déterminer les associations entre, d’une part, les caractéristiques sociodémographiques, les expériences d’apprentissage et la santé générale et mentale perçue et, d’autre part, les difficultés fonctionnelles les plus courantes, celles liées à la mémoire/concentration, à la communication et aux soins personnels. Toutes les estimations ont été pondérées de façon à être représentatives de la population cible. Nous avons utilisé la méthode « bootstrap » pour établir les estimations de la variance.

Résultats

L’analyse des données des 660 enfants et jeunes atteints d’un TSA a révélé que les difficultés fonctionnelles les plus courantes concernaient la mémoire/concentration (22 %; IC à 95 % : 18 à 27), la communication (19 %; IC à 95 % : 15 à 23) et les soins personnels (13 %; IC à 95 % : 10 à 17). Une moins bonne santé mentale perçue était associée à des difficultés fonctionnelles accrues liées à la mémoire/concentration. Un diagnostic de TSA à un plus jeune âge et une moins bonne santé générale perçue étaient associés à des difficultés fonctionnelles accrues liées à la communication. Le fait que les parents avaient des attentes en matière d’études postsecondaires était associé à des difficultés fonctionnelles réduites liées aux de soins personnels.

Conclusion

L’étude a révélé que 39 % des enfants et des jeunes canadiens de 5 à 17 ans ayant reçu un diagnostic de TSA présentaient au moins une difficulté fonctionnelle citée dans l’ensemble de questions WG-SS, les difficultés fonctionnelles liées à la mémoire/ concentration, à la communication et aux soins personnels étant les plus fréquentes.
Health care barriers and perceived mental health among adults in Canada during the COVID-19 pandemic: a population-based cross-sectional study
Authors: Shiraz Mehrunnisa , Capaldi Colin A. , Ooi Laura L. , Roberts Karen C.
Published: January 2024

Introduction

The perceived mental health of individuals in Canada who faced health care barriers during the COVID-19 pandemic is underexplored.

Methods

We analyzed data collected March to June 2021 from adults who reported needing health care services within the past 12 months in the Survey on Access to Health Care and Pharmaceuticals during the Pandemic. Unadjusted and adjusted logistic regression analyses examined the associations between health care barriers (appointment scheduling problems, delaying contacting health care) and high self-rated mental health and perceived worsening mental health compared to before the pandemic, overall and stratified by gender, age group, number of chronic health conditions and household income tertile.

Results

Individuals who experienced pandemic-related appointment changes or had appointments not yet scheduled were less likely to have high self-rated mental health (aOR = 0.81 and 0.64, respectively) and more likely to have perceived worsening mental health (aOR = 1.50 and 1.94, respectively) than those with no scheduling problems. Adults who delayed contacting health care for pandemic-related reasons (e.g. fear of infection) or other reasons were less likely to have high self-rated mental health (aOR = 0.52 and 0.45, respectively) and more likely to have perceived worsening mental health (aOR = 2.31 and 2.43, respectively) than those who did not delay. Delaying contacting health care for pandemic-related reasons was associated with less favourable perceived mental health in all subgroups, while the association between perceived mental health and pandemic-related appointment changes was significant in some groups.

Conclusion

Health care barriers during the pandemic were associated with less favourable perceived mental health. These findings could inform health care resource allocation and public health messaging.
Hubungan Ruang dan Aktivitas Interpersonal pada Penerapan Pembatasan Jarak Fisik di Makam Bung Karno
Authors: Islam Hilmi Dzakaaul
Published: January 2024

Makam Bung Karno adalah ruang publik dan tempat wisata di Kota Blitar yang menjadi tempat aktivitas serta interaksi interpersonal. Pada masa adaptasi kebiasaan baru Covid-19 Makam Bung Karno menerapkan protokol kesehatan penerapan pembatasan jarak fisik (physical distancing) yang bertujuan mengurangi kontak fisik manusia dan lingkungan untuk memutus rantai penyebaran Covid-19. Penerapan pembatasan jarak fisik masih menjadi hal baru dalam kebiasaan aktivitas sosial manusia, sehingga berpotensi memengaruhi aktivitas individu dan ruang aktivitasnya. Tujuan penelitian untuk menjabarkan hubungan ruang dan aktivitas interpersonal pengguna ruang pada penerapan protokol kesehatan pembatasan jarak fisik di Makam Bung Karno. Penelitian menggunakan metodologi kualitatif dengan studi kasus. Proses analisis data menerapkan kajian behavior setting dan setting ruang yang divisualkan dalam behavior mapping untuk menjelaskan fenomena terkait hubungan ruang dan aktivitas pengguna ruang. Hasil penelitian memperlihatkan bahwa di Makam Bung Karno terdapat tiga setting ruang, yaitu fixed element, semi fixed element dan non fixed element yang secara umum mempunyai hubungan dan berpengaruh terhadap perilaku manusia dalam menggunakan ruang.
Analisis Visual Kemasan Kue Gabin Samarinda Untuk Pengembangan Desain Kemasan
Authors: Hidayanto Andi Farid , Atmono Yohanes Firananta Setyo
Published: January 2024

Heritage typical traditional food is the region typical food that is different from those from other regions. In carrying it, the food needs a container in the form of packaging. As a souvenir, the packaging needs to have a uniqueness that can differentiate it from other packages and at the same time can show its identity. One of the difference comes from the attributes of the packaging from the visual side. Because the visual appearance is the first thing that catch the costumers attention and also influences purchasing decisions. So it needs to be analyzed what attributes are required from the visual side.

This is a qualitative reasearch. Preliminary data were obtained from a literature study on food packaging design which was analyzed for its attributes, the results were qualitativeized using the NVivo application. NVivo is used to illustrate the decision analysis results framework by coding the data according to the classification scheme.

The result of this study is the arrangement of the visual attributes of traditional food packaging, which will be applied to develop the packaging design for the Samarinda gabin biscuit, to reconstruct the packaging which is suitable to current taste without losing its original identity.
Performance reconfiguration in Indonesian MSMEs: Digital transformation, emerging skills, and organizational health
Authors: HS Ikhwan , Himawati Ditiya
Published: January 2024

Organisational competitiveness hinges on the strategic integration of digital transformation (DT), emerging skills (ES), and organizational health (OH) to foster sustainable performance. Despite the pivotal role of these variables, limited research investigates their interplay in Micro, Small, and Medium Enterprises (MSMEs) in Indonesia. This study addresses this gap by empirically examining how MSMEs navigate challenges and opportunities amid the digital transformation landscape. Specifically, the research probes the intermediary function of the synergistic integration between DT and ES, influencing organisational performance (OP) moderated by OH. Utilizing a validated questionnaire, a three-month convenience sample involved 120 MSME managers. Partial least squares structural equation modelling analysis was employed to assess hypotheses. Findings indicate a significant relationship between DT, ES, and OH, with DT influencing OP. Interestingly, ES alone does not impact OP. Structural equation modelling reveals OH as a mediating variable between DT, ES, and OP. While the proposed model is preliminary, offering avenues for further research, this study underscores the importance of emerging skills in the MSME sector, contributing to a nuanced understanding of organisational competitiveness dynamics.
Death or Glory: (just another story)
Authors: Villasclaras Hadaly
Published: January 2024

Del 26 de enero al 24 de febrero de 2017. Sala de Exposiciones de la Facultad de Bellas Artes de Málaga
Erótica Inversa
Authors: De la Cruz Paloma
Published: January 2024

27 de abril - 26 de mayo 2017. Sala de Exposiciones de la Facultad de Bellas Artes de Málaga
Fábulas
Authors: Boyano Delia
Published: January 2024

Sala de exposiciones de la Facultad de Bellas Artes de Málaga 8/6 - 28/7/2017
Luna–Lager Bunker
Authors: Rojas Florencia
Published: January 2024

Sala de Exposiciones de la Facultad de Bellas Artes de Málaga. 2 marzo – 6 abril 2017
The perioral muscular phenomenon: Part II.
Authors: Frederick Sidney
Published: January 2024

Over twenty-five years of studying the perioral musculature, clinical observation of the dental and peridental tissues of hundreds of patients, and examining seven anatomy books — have revealed that there is a serious deficiency in our knowledge of this musculature and its effects on the dental tissues and this part of the face. Believed to be of no unusual significance, it has been almost ignored through the years. One hears vague terms such as lip pressure and cheek pressure; but no comprehensive studies of this musculature, how it functions and the effects of these functions are to be found in literature. By its actions, this musculature effects many phases of dentistry, directly or indirectly; and orthodontics is affected most of all. By its manipulations of the dental tissues, the alveolar bone and gingiva, it ultimately determines the position of the teeth. Almost every person exhibits pressure signs or damage to the tissues. The only exceptions are babies. By reading these signs, the strength and physical configuration of the pertinent parts of the musculature can be determined. This ability to ‘read the signs’ should be developed since it helps fine tune the diagnostic process. Only by this means may the correct surgical procedures be carried out. A representative sample from over 1200 cases treated in this manner in more than twenty years will be shown.
Analysis of activator treatment changes
Authors: Hashim Hanizah Aman
Published: January 2024

The effects of functional appliance treatment have been reported in numerous studies in the literature with great variability in the findings. It is generally agreed that they can be used successfully to treat Class II malocclusions in growing and cooperative patients. However, there is a lack' of consensus regarding the relative orthodontic and orthopedic correction obtained by functional appliances in Class II correction. Lateral cephalometric radiographs from a sample (n=36) of patients who had undergone a phase of treatment with activator appliances were measured and analysed for changes using a modified version of the method described by Johnston (Hashim and Godfrey 1990). In this method, the treatment changes were broken down into: tooth movement relative to basal bone; and the translatory growth of the jaws, both with respect to the cranial base and to each other. The results show that the treatment effects were mainly dentoalveolar. There was a slight orthopedic effect on the maxilla, but no significant mandibular growth was observed, above that which can be expected from normal growth.
Eicosanoids: physiology update and orthodontic implications
Authors: Collett Anthony R. , Stewart Alastair G.
Published: January 2024

The eicosanoids are members of a group of substances comprising prostaglandins and Ieukotrienes which are released by a host of mechanical, thermal, bacterial and other insults and contribute importantly to the signs and genesis of inflammation (Brain and Williams 1990, Dusting 1989 Moncada et al. 1985, Salmon and Higgs 1987). In this review we examine the increasing number of reports on the actions of eicosanoids on the dentoalveolar complex. In addition, since it is desirable for the orthodontist to have a sound knowledge, not only of the roles of eicosanoids in tooth movement, but also of their basic general physiology, an overview of the latter area is presented.
The Treatment of Traumatized Permanent Anterior Teeth: Case Report & Literature Review Part I - Mangement of Inruded Incisors
Authors: Jacobs Stanley G.
Published: January 2024

A case is reported in which an intruded incisor was initially treated by an endodontic dressing with calcium hydroxide and then extruded using a removable orthodontic appliance.

A follow-up examination seven years after completion of endodontic therapy and bleaching showed a favourable response.

A review of the relevant literature indicates that intrusion occurs in five to twelve per cent of luxation cases.

In this type of injury maximum damage occurs to the pulp and all supporting structures because the tooth is driven into the alveolar process.

Complications which have been reported include: pulp necrosis, apical radiolucencies, partial or total pulp calcification, root resorption (surface, inflammatory or replacement), marginal periodontal bone breakdown, and arrested or disturbed root development.

The prognosis for pulp survival after intrusion is much more favourable for teeth with incomplete root formation than for teeth with complete root formation.

Treatment options available to bring an intruded tooth into alignment are: to await spontaneous re-eruption which may occur if root formation is incomplete, uncovering of the intruded crown, orthodontic extrusion which is allied with gentle luxation if the tooth does not move, and immediate surgical repositioning.
A Simple Mathematical Study of Anterior Dental Relations: Part I
Authors: Cordato Mark A.
Published: January 2024

A mathematical study of the anterior dental relations could provide a rationale for the work of Neff and Bolton. Bolton used normal occlusions of permanent teeth to obtain his range of comparisons of tooth width ratios; a model that needs no normals is described in this study. Use of this model and its development could support or disprove forther hypotheses regarding anterior occlusion. Manipulation of the model could allow a means of estimating the influence of several dental measurement variables on the relation between upper and lower dental arches.

The formulae allow changes in the form and size of one or both arches individually and a comparison of an upper arch to different upper arches and a lower arch to different lower arches; and forther, they allow these combinations of upper and lower arches to relate to each other. A reference plane between the arches is established to relate oppesing arches to each other. The model is developed using the archform and angular measures of Bonwill and the mesiodistal widths of Bolton. Scope is provided in the model to allow for alteration of antero-pesterior relations, spacing and crowding.

Values for different amounts of overjet of incisors and maxillary canine tip could be generated by altering the flgures to those of other authors' hypotheticals or by the use of individual patient data.
Correlation of Sexual Maturation with Stature and Body Weight & Dental Maturation in Southern Chinese Girls
Authors: So Lisa L.Y.
Published: January 2024

Correlation of stature and body weight and the eruption of permanent teeth with four sexual maturity criteria (menarche, pubic hair, axillary hair and breast development) was studied in 102 Southern Chinese girls aged between 11 years, 9 months and 12 years, 3 months and born and brought up in Hong Kong. With respect to all four selected criteria, the early sexual maturers were significantly taller and heavier and had more erupted permanent teeth with p values ranging from <0.01 to <0.001 levels than the late maturers.
Oscillation Theorems for Nonlinear Second-Order Delay Differential Equations with Some Sublinear Neutral Terms Via Canonical Transform
Authors: Chatzarakis George E. , Deepalakshmi Rajasekar , Saravanan Sivagandhi , Thandapani Ethiraju
Published: January 2024

New sufficient conditions for oscillation of a second-order nonlinear differential equation with some sublinear neutral terms are established via canonical transform and integral averaging method. Examples are provided to illustrate the significance and novelty of the presented results.
ANALISA KEBERSIHAN PANEL SURYA TERHADAP KELUARAN PLTS ON-GRID 200 KWP BANDARA UDARA SULTAN MUHAMMAD SALAHUDIN BIMA
Authors: Sandrawati Syafiatun , Satya kumara I Nyoman , Setiawan I Nyoman
Published: January 2024

Sultan Muhammad Salahuddin Bima Airport is one of the few airports in Indonesia that has PLTS as a supplier of electrical energy. The existence of PLTS at each airport is a concern for further analysis, so that the potential for electrical energy production from PLTS can be optimal. So the solar module which is the main component of PLTS is very important to pay attention to cleanliness from dirt or dust that can reduce the efficiency and electricity production of PLTS. The measurement of PLTS energy production at Sultan Muhammad Salahuddin Bima Airport before cleaning was 567.56 kWh and after cleaning it was 576.86 kWh. In this measurement, cleaning was carried out on a series of 1 Inveter with a total of 100 solar panels. There is a change in energy production from the measurement results. This condition is due to solar panels that have not been cleaned for 1 year. So that the percentage increase in PLTS energy production at Sultan Muhammad Salahuddin Bima Airport is 1.63%.
RANCANG BANGUN WEB MONITORING SISTEM PADA MESIN KONVERSI LIMBAH ORGANIK MENJADI ENERGI LISTRIK
Authors: Puspitawati Luh Eka , Sukadarmika Gede , Arsa Suyadnya I Made
Published: January 2024

UD. Nadi Utama is one of the producers and distributors of traditional snacks. As a snack producer, UD Nadi Utama supplies 5 minimarkets every day. To support its business, UD Nadi Utama installs PLN electricity with an average electricity payment of IDR 750,000 per month which is considered to burden production costs. After conducting observations, the capstone project team found that UD, Nadi Utama produces 25 kg of coconut fiber and shell per day. From the problems and potential found at UD Nadi Utama, team capstone project provides a solution in the form of an incinerator. This incinerator has a converter device that can convert the heat generated from combustion into electrical energy. However, monitoring the data of voltage, current, temperature, and the power generated by this incinerator is quite difficult for ordinary users. Because the resulting data is stored in a data logger that can only be downloaded in the form of excel files and cannot be known directly (real-time). This makes it difficult to know when the temperature of the device has decreased, and the amount of power generated by the device. At UD Nadi Utama itself, its human resources have a good ability to use the web system on their mobile devices. From the problems with the conversion tool and the potential of human resources at UD Nadi Utama. A website-based monitoring system is created, which displays the data generated by the data logger in almost real time.