bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of an 8-week Yoga Intervention among Middle-aged and Older Adults
Authors: Gothe Neha P. ,   Kinesiology and Community Health University of Illinois at Urbana Champaign, Urbana, IL, USA, Erlenbach Emily
Published: November 2020

Feasibility studies play a critical role in determining whether the target population is likely to engage with larger scale efficacy and effectiveness trials. Feasibility data for yoga interventions designed and conducted with older adults is limited. In this paper we present feasibility and acceptability data from an 8-week randomized controlled trial (RCT) conducted with middle aged and older adults. Participants n=118 (Mean age: 62.0 years) were randomized to either a Hatha yoga or Stretching Control group with hour long group exercise classes held 3x/week for 8 weeks. Herein we report feasibility and acceptability, including enrollment rates, attendance, attrition and adverse events, participant feedback and satisfaction data. Of the 265 adults screened, 118 were eligible and randomized. Session attendance was high for both groups (80.82 to 81.29 %) and only 10 people were lost to follow-up. Program satisfaction for both groups was high (4.8 and 4.86 out of 5) and no adverse events were reported. Participants’ feedback regarding most and least helpful aspects of the program as well as suggestions for future yoga interventions are summarized. Overall, the yoga intervention was highly feasible and acceptable. The feasibility parameters from this trial can aid researchers in estimating desired sample sizes to successfully recruit, randomize and retain older adults in short- and long-term yoga based RCTs.
The Impact of Synchronous Telehealth Services With a Digital Platform on Day-by-Day Home Blood Pressure Variability in Patients with Cardiovascular Diseases: Retrospective Cohort Study
Authors: Chen Ying-Hsien , Hung Chi-Sheng , Huang Ching-Chang , Lee Jen-Kuang , Yu Jiun-Yu , Ho Yi-Lwun
Published: November 2020

Background

Hypertension is associated with a large global disease burden with variable control rates across different regions and races. Telehealth has recently emerged as a health care strategy for managing chronic diseases, but there are few reports regarding the effects of synchronous telehealth services on home blood pressure (BP) control and variability.

Objective

The objective of this study is to investigate the effect of synchronous telehealth services with a digital platform on home BP.

Methods

This retrospective study was conducted by the Taiwan ELEctroHEALTH study group at the Telehealth Center of the National Taiwan University Hospital. We analyzed home BP data taken from 2888 patients with cardiovascular disease (CVD) enrolled in our telehealth program between 2009 to 2017. Of the 2888 patients with CVD, 348 (12.05%) patients who received home BP surveillance for ≥56 days were selected for BP analysis. Patients were stratified into three groups: (1) poorly controlled hypertension, (2) well-controlled hypertension, and (3) nonhypertension. The mean, SD, coefficient of variation (CV), and average real variability were calculated.

Results

Telehealth interventions significantly and steadily reduced systolic blood pressure (SBP) in the poorly controlled hypertension group from 144.8.2±9.2 to 133.7±10.2 mmHg after 2 months (P<.001). BP variability reduced in all patients: SBP-SD decreased from 7.8±3.4 to 7.3±3.4 after 2 months (P=.004), and SBP-CV decreased from 6.3±2.5 to 5.9±2.6 after 2 months (P=.004). Event-free survival (admission) analysis stratified by SBP-SD showed longer time to first hospitalization for Q1 patients compared with Q4 patients (P=.02, odds ratio 2.15, 95% CI 1.18-3.89).

Conclusions

Synchronous telehealth intervention may improve home BP control and decrease day-by-day home BP variability in patients with CVD.
Patient Triage by Topic Modeling of Referral Letters: Feasibility Study (Preprint)
Authors: Spasic Irena , Button Kate
Published: November 2020

BACKGROUND

Musculoskeletal conditions are managed within primary care, but patients can be referred to secondary care if a specialist opinion is required. The ever-increasing demand for health care resources emphasizes the need to streamline care pathways with the ultimate aim of ensuring that patients receive timely and optimal care. Information contained in referral letters underpins the referral decision-making process but is yet to be explored systematically for the purposes of treatment prioritization for musculoskeletal conditions.

OBJECTIVE

This study aims to explore the feasibility of using natural language processing and machine learning to automate the triage of patients with musculoskeletal conditions by analyzing information from referral letters. Specifically, we aim to determine whether referral letters can be automatically assorted into latent topics that are clinically relevant, that is, considered relevant when prescribing treatments. Here, clinical relevance is assessed by posing 2 research questions. Can latent topics be used to automatically predict treatment? Can clinicians interpret latent topics as cohorts of patients who share common characteristics or experiences such as medical history, demographics, and possible treatments?

METHODS

We used latent Dirichlet allocation to model each referral letter as a finite mixture over an underlying set of topics and model each topic as an infinite mixture over an underlying set of topic probabilities. The topic model was evaluated in the context of automating patient triage. Given a set of treatment outcomes, a binary classifier was trained for each outcome using previously extracted topics as the input features of the machine learning algorithm. In addition, a qualitative evaluation was performed to assess the human interpretability of topics.

RESULTS

The prediction accuracy of binary classifiers outperformed the stratified random classifier by a large margin, indicating that topic modeling could be used to predict the treatment, thus effectively supporting patient triage. The qualitative evaluation confirmed the high clinical interpretability of the topic model.

CONCLUSIONS

The results established the feasibility of using natural language processing and machine learning to automate triage of patients with knee or hip pain by analyzing information from their referral letters.
Patient and Professional Experiences With Virtual Antenatal Clinics During the COVID-19 Pandemic in a UK Tertiary Obstetric Hospital: Questionnaire Study (Preprint)
Authors: Quinn Lauren Marie , Olajide Oluwafumbi , Green Marsha , Sayed Hazem , Ansar Humera
Published: November 2020

BACKGROUND

The COVID-19 pandemic required rapid implementation of virtual antenatal care to keep pregnant women safe. This transition from face-to-face usual care had to be embraced by patients and professionals alike.

OBJECTIVE

We evaluated patients’ and professionals’ experiences with virtual antenatal clinic appointments during the COVID-19 pandemic to determine satisfaction and inquire into the safety and quality of care received.

METHODS

A total of 148 women who attended a virtual antenatal clinic appointment at our UK tertiary obstetric care center over a 2-week period provided feedback (n=92, 62% response rate). A further 37 health care professionals (HCPs) delivering care in the virtual antenatal clinics participated in another questionnaire study (37/45, 82% response rate).

RESULTS

We showed that women were highly satisfied with the virtual clinics, with 86% (127/148) rating their experience as good or very good, and this was not associated with any statistically significant differences in age (P=.23), ethnicity (P=.95), number of previous births (P=.65), or pregnancy losses (P=.94). Even though 56% (83/148) preferred face-to-face appointments, 44% (65/148) either expressed no preference or preferred virtual, and these preferences were not associated with significant differences in patient demographics. For HCPs, 67% (18/27) rated their experience of virtual clinics as good or very good, 78% (21/27) described their experience as the same or better than face-to-face clinics, 15% (4/27) preferred virtual clinics, and 44% (12/27) had no preference. Importantly, 67% (18/27) found it easy or very easy to adapt to virtual clinics. Over 90% of HCPs agreed virtual clinics should be implemented long-term.

CONCLUSIONS

Our study demonstrates high satisfaction with telephone antenatal clinics during the pandemic, which supports the transition toward widespread digitalization of antenatal care suited to 21st-century patients and professionals.
Испытания высокоточных шпинделей с помощью голографических наноизмерительных систем ЛГИИС
Authors: Турухано Б.Г. , Турухано Н. , Ханов С.Н. , Лавров Ю.М. , Константинов Л.А. , Ермоленко О.Г. , Добырн В.В. , Синельщикова Р.П.
Published: November 2020

В данной работе исследуются радиальное и осевое биения шпинделя с помощью прецизионных наноголографических измерительных систем – линейных и угловых перемещений – длинномеров и ультрапрецизионного поворотного стола. Точность вращения шпинделя оценивается по величине радиального и осевого биения его переднего конца. Шпиндель осуществляет механическое вращательное движение. При вращательном движении шпинделя все его точки, в том числе и внешней поверхности, описывают окружности, расположенные в параллельных плоскостях. Центры всех окружностей лежат при этом на одной прямой, перпендикулярной к плоскостям окружностей называемой осью вращения. Ось вращения шпинделя располагается внутри его. Биения шпинделя исследуются по его верхней и боковой поверхностям.
Artificial Reflector for Setting up a Flaw Detector that Implements an Acoustic Waveguide Method for Monitoring Composite Reinforcement
Authors: Strizhak V. A.
Published: November 2020

Предложен способ нанесения искусственного отражателя на длинномерный объект без разрушения его тела, что позволяет разработать настроечный образец для волноводного метода контроля при упрощении способа нанесения искусственного отражателя. На основании существующих методик оценки спектральных свойств сигналов, отраженных и прошедших через участки с перепадом сечения, разработана расчетная модель. Модель позволяет оценить амплитуды эхосигналов в зависимости от высоты и длины искусственного отражателя. Приведены результаты моделирования и экспериментальных исследований влияния габаритных размеров искусственного отражателя на эхосигнал. Показано, что максимум эхосигнала достигается при длине искусственного отражателя на 19 % меньше значения, соответствующего критерию четверти волнового резонанса. Амплитуда от искусственного отражателя в 1,2…1,3 раза меньше процента прироста площади, и с увеличением площади в зоне отражателя различия растут в силу уменьшения коэффициента его прозрачности.Полученные зависимости позволяют по амплитуде эхосигнала и видимой длине дефекта оценить его внутренний размер. Предлагаемая методика характеризуется высокой точностью, оперативностью и позволяет повысить достоверность волноводного метода контроля длинномерных объектов из полимерных композитных материалов (пруток, труба, арматура).
Rotavirus gastroenteritis as a precipitating factor of celiac crisis in infancy: Case reports and review of literature
Authors: Lekovic Zoran , Radlovic Vladimir , Jovicic Nevena , Djuricic Goran , Mladenovic Marija , Dasic Ivana , Radlovic Nedeljko
Published: November 2020

Introduction. Celiac crisis is a rare and life-threatening complication of celiac disease. Although it occurs in all ages, the most common affects children within the first two years. Outline of cases. We report three infants (two female, one male, age range 9?12) with celiac crises as an initial presentation of celiac disease precipitated with rotavirus gastroenteritis. Celiac crisis was preceded by failure to thrive caused by anorexia, occasional vomiting and frequent abundant stools for 4?8 weeks, and 1?2 days before admission with fever, frequent vomiting and profuse watery diarrhea. They were admitted in a very severe general condition, severely dehydrated, markedly malnourished, with an enormously distended abdomen, edema of the lower legs and feet, and perianal erythema. After correction of dehydration and hypoalbuminemia, they were placed on a gluten- and disaccharide-free diet and within the first two weeks on additional parenteral nutrition. The applied therapeutic measures resulted in stabilization and further rapid improvement of the patient?s condition. In all three patients the latex agglutination test for rotavirus was positive, IgA anti-TTG antibodies elevated (58.6?78 U/ml) and all three were homozygous carriers of the HLA DQ2 gene. Enterobiopsy was performed two weeks after the admission and total villous atrophy (Marsh IIIc) was registered in all three patients. In the further course, the complete recovery of the patient was accomplished by a strict gluten-free diet. Conclusion. Our experience indicates that rotavirus gastroenteritis in timely unrecognized classical celiac disease in infants can lead to celiac crisis.
How and when do we use continuous renal replacement therapy for acute kidney injury in Serbia? - The multicentric survey
Authors: Knezevic Violeta , Celic Dejan , Azasevac Tijana , Golubovic Sonja , Sladojevic Vesna , Nestorov Natasa , Maksic Djoko , Naumovic Radomir , Lazarevic Tatjana , Neskovic Vojislava
Published: November 2020

Background/Aim. The absence of clear guidance in the definition, diagnostics, and indications for renal replacement treatment (RRT) is present. The aim of this study was to help outlining future clinical work in improving the treatment outcome and reducing complications of acute kidney injury (AKI) based on the current clinical practice. Methods. The questionnaires were distributed among physicians of different specialties who participated voluntarily and anonymously. The questionnaire was drawn up in accordance with the standard clinical practice. Results. We conducted a multicentric web survey among nephrologists (46.8%) and other physicians in Serbia. The sample consisted of 119 participants, out of which 78.9% filled out the survey forms correctly and were, therefore, included in the analysis. Most of them responded that the nephrologist indicates (76.8%) and prescribes (74.5%) continuous renal replacement therapy (CRRT). The application of the Kidney Disease Improving Global Outcomes (KDIGO) 2 criterion for ?early? start of CRRT used 74.5% of the respondents, and 91.5% of them started ?late? initiation of CRRT in the presence of complications associated with AKI or poor response to conservative treatment. Regarding the clinical experience of the respondents, 74.5% of them marked the ?early? start of CRRT within 12 hours, whereas 56.4% of them considered the start of CRRT after 48 h as ?late?. The most commonly used modality was continuous venous hemodiafiltration (37.6%). Most participants used heparin as an anticoagulant (95.7%) with an average life span of filters less than 24 h (71.3%) and 25 mL/kg/h efficiency target dialysis effluent dose (45.2%) during CRRT. The most common complications of CRRT were hypotension (55.3%) and catheter-related infections (29.8%). Conclusion. The ?early? start of CRRT is considered favorite by the majority of the participants. According to the obtained data, standardization of the strategy in the diagnostics and treatment of AKI is necessary.
DEVELOPMENT AND TESTING OF A MEASURING COMPLEX FOR MONITORING THERMAL PARAMETERS OF THE CONTINUOUS CASTING MOLD
Authors: VINOGRADOV VASILIY P. , KUZMINOV ALEXANDER L.
Published: November 2020

he authors consider the methodology for studying thermal parameters of the mold using a measuring complex of dual-zone thermocouple sensors. The article describes experimental work on establishing the relationship between the surface quality indices of slab billets and technological parameters, thermotechnical indicators of the mold and the chemical composition of cast steel.
NEGATIVE ASSESSMENT IN ENGLISH STYLIZED COMMUNICATION: OPTIONS FOR RESPONSE SPEECH BEHAVIOUR
Authors: STAROSTINA IULIA S. , CHERKUNOVA MARINA V.
Published: November 2020

The article deals with the functional aspect of negative assessment in English stylized colloquial speech. The authors aim at systematizing the options for response speech behaviour in terms of employed speech patterns, with special attention paid to extralinguistic causes for addressee’s conduct. Three response strategies are singled out, namely disregard, acceptance, and doubt in negative assessment. The authors also consider how a definite response depends on extralinguistic factors, such as level of interpersonal relationships, age parameter, and importance of the object under evaluation.
INFORMATION PROCESSING MODULE IN THE AUTOMATED SYSTEM FOR INDUSTRIAL SAFETY CONTROL AT AN INDUSTRIAL ENTERPRISE
Authors: EGOROVA LYUDMILA G. , SUKHODOEV VLADISLAV A. , LOGUNOVA OKSANA S.
Published: November 2020

Labor protection and industrial safety are of great importance in the production activities of an industrial enterprise. The effective functioning of the occupational health and safety management system reduces the risk of accidents. Analysis of information that characterizes the state of labor protection and industrial safety requires large data processing. This article discusses the implementation of the module on accounting and analyzing the results of control and preventive activities in the field of industrial safety and labor protection. Its practical relevance consists in consolidating data on industrial safety, reducing the time for information processing, and increasing the reliability of information on the state of industrial safety at the enterprise.
STOCHASTIC CALCULATION OF LIFETIME PREDICTION FOR COMPONENTS IN METAL STRUCTURES DUE TO THE GROWTH OF MICRODEFECTS
Authors: SILVERSTOV IGOR N.
Published: November 2020

A stochastic approach has been developed to evaluate fatigue strength using elements of the fracture mechanics. The article presents a method for determining the initial parameters of statistical distributions. It also considers the method for constructing a fatigue curve for a component of any size and configuration with any given probability of failure.
Detection and analysis of antibiotic resistance variability among Staphylococcus aureus isolates from animal and human sources
Authors:   Department of Veterinary Microbiology and Biotechnology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, (Rajasthan), India, Sharma Sandeep K. , Yadav Rahul , Mehta Sharat C. , Kataria Anil K.
Published: November 2020

In consideration of the importance of Staphylococcus aureus regarding its contribution to antibiotic resistance, the present study was designed to find variability among S. aureus isolates in relation to their multidrug resistance patterns. A total of 157 species-specific 23S rRNA based confirmed S. aureus isolates from various clinical and non-clinical animal sources (cattle, buffalo, goat, sheep, dog, camel, pig and horse), human and pieces of meat from butcher shops were included in the present study. Overall more than 95% isolates were recorded resistant to ampicillin and penicillin-G, while approximately 100% isolates were sensitive to chloramphenicol, meropenem and nitrofurantoin. The isolates from different sources showed highly significant (P≤0.01) variation in their resistance patterns for 39 antibiotics, significant variation (p≤0.05) for levofloxacin and nitrofurantoin, and no significant variation (P>0.05) for clindamycin. In Bonferroni correction, human isolates were significantly variable with a p˂0.0001 probability level of variance in relation to other pieces of meat and animal origin sources for most of the antibiotics. Human isolates had the highest (0.40) MAR index. A highly significant difference was observed in the antibiogram pattern between different sources of S. aureus, which may indicate the pattern and frequency of use of various antibiotics in humans and animals.
Molecular characterization of the hemagglutinin gene of H9N2 avian influenza viruses isolated from broiler flocks in Morocco from 2016 to 2018
Authors:   Department of Genetics and Biometry, Faculty of Sciences of Kenitra University IbnTofail, Kenitra, Morocco, El Khantour Abderrazak , Soulaymani Abdelmajid , Salek Mohamed , Filali Maltouf Abdelkarim , Darkaoui Sami , El Mellouli Fatiha , Ducatez Mariette F. , Fellahi Siham
Published: November 2020

Avian influenza viruses of the H9N2 subtype continue to spread in wild birds and poultry worldwide. Infection with H9N2 avian influenza virus was detected for the first time in Morocco in January 2016. In this study, a total of 105 organ and tracheal swab samples from 21 broiler farms in Morocco were collected from July 2016 to October 2018 for H9N2 screening. The suspicion of disease was based on severe respiratory signs such as sneezing, coughing, rales and gasping, while H9N2 virus infection was confirmed by real-time RT-PCR. Hemagglutinin (HA) genes of four isolates were amplified by conventional RT-PCR, sequenced, and aligned for phylogenetic analyses. Among the 21 flocks, 48% (10/21) were qRT-PCR positive for H9, with the cycle threshold values ranging from18.6 to 34.8. The maximum similarity in nucleotide and protein sequences (96-98%) was observed between the Moroccan viruses and an H9 virus isolated from broiler chickens in 2017 in Burkina Faso (A/chicken/BurkinaFaso/17RS93-19/2017) and from a layer chicken in the United Arab Emirates in 2015 (A/chicken/Dubai/D2506/2015). The HA genes revealed the close relationship between the four Moroccan viruses, with 97.9%-99.9% nucleotide identity. Phylogenetic analysis showed that the Moroccan viruses belonged to the G1 lineage, and likely originated from the Middle East, as previously reported in 2016.
An unusual case of ectopic abdominal pregnancy in a bitch - a case report
Authors:   Department of Veterinary Surgery, Veterinary Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina, Maksimović Alan , Preldžić Dajna , Lutvikadić Ismar , Zahirović Amir , Hadžijunuzović-Alagić Dženita , Čamo Denis
Published: November 2020

There are only a few reported cases of abdominal ectopic pregnancy and consequential foetal mummification in dogs. The majority of the described cases indicate that this condition may exist for a prolonged period of time without any manifestation of illness. Therefore, sudden signs of abdominal distension, abdominal pain, episodes of epileptiform seizures, dark diarrhoea and lethargy, as were observed in the present case, are not likely to be considered as symptoms of an abdominal ectopic pregnancy. Furthermore, to the best of our knowledge, this is the first report of an eight-year long abdominal pregnancy in an ovariohysterectomised bitch. We present the clinical, laboratory, radiological and intraoperative findings, and the medical and surgical therapy for an abdominal ectopic pregnancy in a 14 year old Miniature Pinscher bitch, ovariohysterectomised eight years previously.
Molecular detection and genomic characterisation of Torque teno canis virus in Turkey
Authors:   Virology Department, Faculty of Veterinary Medicine, Sivas Cumhuriyet University,  Sivas, Turkey, Turan Turhan , Işıdan Hakan , Atasoy Mustafa Ozan
Published: November 2020

Torque teno virus (TTV) was first detected in humans, and since then it has been reported in many host species, such as monkeys, cats, pigs, seagulls and dogs. The aim of this study was to investigate the presence of Torque teno canis virus (TTCaV) in shelter dogs housed in Sivas Municipal Animal Shelter, Turkey. Faecal specimens, including diarrheic and non-diarrheic (n=202), were collected from dogs of various age groups. In total, 32.18% (65/202) of samples were found positive for TTCaV. Out of the 65 positive samples, 34.64% (44/127) samples were from adult diarrheic dogs and 26.09% (6/23) belonged to diarrheic puppies. On the other hand, 28.84% (15/52) positive samples were detected from clinically healthy dogs. Eight sequences showed close homology among themselves, however, the sequences of two samples (CANEL130 and CANEL140) were genetically distinct from other published sequences. This is the first report on the detection of TTCaV in adult dogs and puppies in Turkey, and provides evidence that TTCaV cannot be considered as the sole cause of diarrhea.
Optimization of the method for isolation of epithelial cells from the non-glandular part of the rat stomach for flow cytometry
Authors:   „VINČA” Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Begrade, Republic of Serbia, Joksić Gordana , Filipović Tričković Jelena , Mićić Mileva , Joksić Ivana , Valenta Šobot Ana , Demajo Miroslav
Published: November 2020

Traditional methods in cell proliferation studies are based on immunohistochemical detection of proliferating cells in the target tissue. Since they are time consuming, optimization of novel, more efficient methods is important for large scale proliferation studies. In this study, we aimed to optimize the isolation of single epithelial rat forestomach cells for flow cytometry. As a marker of cellular proliferation we used the Ki-67 antibody to detect this nuclear protein expressed in proliferating cells. We also performed immunohistochemical detection of Ki-67 positive cells and propidium iodide staining to validate the results. 3-tert- butyl -4-hydroxyanisole was used as the positive control to ensure cellular proliferation. The results showed that isolation of epithelial cells with collagenase, trypsin and cell strainer ensures great cell viability (>95%) and the purity of the samples. Flow cytometry and immunostaining with the Ki-67 antibody indicated that 3-tert- butyl-4-hydroxyanisole treatment leads to a significant increase in proliferation. A significant positive correlation was observed between the results obtained by immunohistochemistry and flow cytometry, but the flow cytometric data had a smaller measurement error, suggesting the equal sensitivity and greater accuracy of this method. Propidium iodide staining showed that the percentage of cells in the G2+S phase of the cell cycle correlated positively with the percentage of Ki-67 positive cells assessed by flow cytometry, indicating that Ki-67 positive cells reflect an active dividing cell pool. We conclude that the isolation of forestomach epithelial cells described is a simple and reliable method for obtaining viable cells for use in flow cytometry. Compared to immunohistochemistry, flow cytometric detection of the Ki-67 antigen is equally sensitive, but much faster and provides more accurate results.
Trade-off between fast growth and the ossification process in common carp (Cyprinus carpio)
Authors:   Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb,  Zagreb, Croatia, Kužir Snježana , Drašner Krešimir , Matanović Krešimir , Bastiančić Lucija , Vlahek Ivan , Savoca Serena , Gjurčević Emil
Published: November 2020

The relationship between growth rate and ossification is not consistent among fish. In some species, fast-growing individuals ossify earlier, while in other species, a trade-off between growth rate and ossification exists. This research was conducted to test the hypothesis about the existence of a trade-off mechanism in common carp offspring. For this purpose, specimens from two groups of common carp offspring (96 in total) with different growth rates were sampled at multiple time points between 5 and 29 days post-hatching. The standard length was measured and presented in correlation with the days post-hatching. To evaluate the skeletal system development, whole specimens were fixed in 10% neutral buffered formalin and stained for bone and cartilage. Particular emphasis was placed on the onset of ossification in the clearly visible bones of the head, vertebral column, and fins. According to our findings, larger, fast-growing specimens ossify earlier. The hypothesis on the existence of a trade-off between fast growth and the onset of ossification in common carp was not confirmed in our study.
El pintor Francisco Agustín Grande y el obispo don Antonio Caballero y Góngora. La Piedad del retablo del Sagrario de la parroquia de San Miguel, Córdoba (1795)
Authors: Nieto Márquez Miguel Ángel
Published: November 2020

A finales del siglo XVIII, el obispo ilustrado D. Antonio Caballero y Góngora fundó en Córdoba la Escuela de Bellas Artes, que fue dirigida por el pintor académico Francisco Agustín Grande. El presente artículo pone de relieve el apoyo que el pintor recibió del prelado, interesado en la difusión del gusto academicista, siendo prueba de ello el lienzo de La Piedad de la capilla sacramental de la parroquia de San Miguel.
Effect of Copper Slag as a Fine Aggregate on the Durability Characteristics of High-Performance Concrete (HPC) Containing Silica Fume
Authors:   Associate Professor, Department of Civil Engineering, Zakir Husain College of Engineering and Technology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, Khan Rizwan Ahmad
Published: November 2020

This paper investigates the fresh and durability properties of the high-performance concrete by replacing cement with 15% Silica fume and simultaneously replacing fine aggregates with 25%, 50%, 75% and 100% copper slag at w/b ratio of 0.23. Five mixes were analysed and compared with the standard concrete mix. Fresh properties show an increase in the slump with the increase in the quantity of copper slag to the mix. Sorptivity, chloride penetration, UPV and carbonation results were very encouraging at 50% copper slag replacement levels. Microstructure analysis of these mixes shows the emergence of C-S-H gel for nearly all mixes indicating densification of the interfacial transition zone of the concrete.
Strategic Risk Management Practice in Urban Road Construction Project of Nepal
Authors:   Associate Professor, Madan Bhandari Memorial Academy Nepal and Pokhara University, Morang, Nepal, Mishra Anjay Kumar
Published: November 2020

Risk management effectiveness assures project success. The overall objective of this research is to analyze the risk management practice in an urban road construction project with a case of Shiddharthanagar Municipality, Rupandehi, Nepal from contractor’s and client’s perspective. This research is based on a scheduled questionnaire survey to collect the primary data using convenient sampling of the partially or fully completed project. Contractors are quite aware of risk management and the percentage of awareness is even higher among the clients. The feedback from a similar project was used as the main method to identify the potential risk of the project from both contractor’s and client’s perspective. Direct judgment method is used maximum to the analyzed risk of the project from the contractor’s perspective as well as scenario analysis from the client’s perspective. Monitor the risk and prepare a contingency plan is used mostly for risk response of the project from both contractor’s and client’s perspective. An alternative plan, subjective judgment, close supervision, increment of resources and change in construction methods were applied as a preventive and remedial strategy. Risk should be managed by the one who is capable of managing the particular risk by managing contractual obligation with proper contract administration practices for ensuring the project objectives. There should be a risk register at the site and a frequent meeting should be conducted to identify the risks. These identified risks should be documented properly to ensure expertise for future projects.
Energy Crisis, Resource Scarcity, and Innovations in Biofuels
Authors:   Tech. Research Scholar (Renewable Energy), Manda Institute of Technology, Bikaner, Rajasthan, India, Jain Nirupa
Published: November 2020

Natural resources are scarce and there is a need to explore new resources to meet the rising demand for energy. There is also a need to meet sustainable development goals through proper planning and strategy. Fossil fuel has a finite supply and there will be a huge gap between demand and supply due to rising demand. There is a need to develop biofuel to replace fossil fuel. This paper gives a discussion about current issues and future directions in these sectors.
Influence of catecholic ring torsion on hydroxyflavones
Authors: Michalík Martin , Biela Monika , Cagardová Denisa , Lukeš Vladimír
Published: November 2020

Systematic quantum chemical investigation of quercetin and selected eight mono- and bihydroxyflavonols is presented. Structural analysis based on the Density Functional Theory showed that the energetically preferred conformation of flavonols substituted at the C5 and C3 atoms by a hydroxyl group is stabilised via intramolecular hydrogen bonds occurring between the (C4)O···HO(3 or 5) atomic pairs. Depending on the hydroxyl group positions, energetically preferred torsional orientation of the phenyl ring with respect to the planar benzo-γ-pyrone moiety changed from 0 to 180 degrees. Gas-phase electron transitions were investigated using the time-dependent DFT treatment. The dependence of maximal wavelengths on the torsional deformation of the phenyl ring is of a similar shape, i.e. minima observed for the perpendicular orientation and maxima for the planar one. Shape and energies of the Highest Occupied (HOMO) and Lowest Unoccupied (LUMO) Molecular Orbitals were compared. The obtained theoretical results were compared with available experimental data.
Carbon family nanomaterials — new applications and technologies
Authors: Roupcova Petra , Klouda Karel , Brandeburova Paula , Sipos Rastislav , Hives Jan , Gal Miroslav , Mackulak Tomas , Skrizovska Michaela , Kissikova Lenka
Published: November 2020

Research on carbon-based nanomaterials (CBNMs) and their development is one of the major scientific disciplines of the last century. This is mainly because of their unique properties which can lead to improvements in industrial technology or new medical applications. Therefore, it is necessary to examine their properties such as shape, size, chemical composition, density, toxicity, etc. This article focuses on the general characteristics of nanomaterials (NMs) and their behavior when entering the environment (water and soil). In addition, it presents individual members of the graphene family including porous ecological carbon (biochar). The article mainly deals with the new potential technologies of CBNMs considering their possible toxic and genotoxic effects. This review also highlights the latest developments in the application of self-propelled micromotors for green chemistry applications. Finally, it points to the potential biomedical applications of CBNMs.
Pichia pastoris — recombinant enzyme producent for environment treatment — review
Authors: Kyzeková Tamara , Krasňan Vladimír , Rebroš Martin
Published: November 2020

Since environmental pollution is increasing, scientists try to find a sustainable way for its clean up and for environment protection. Due to increasing knowledge of genetics and recombinant technologies, recombinant enzymes have been increasingly applied for these purposes. This article deals with the possibilities of environmental treatment with different types of enzymes produced by P. pastoris. Environment is polluted mostly with pesticides, wastewaters, phenol compounds, plastics, toxic compounds, wastes from medical treatment, etc. All these compounds have to be eliminated considering the deteriorating biodiversity, human health, and condition of plants. Enzymes are an environmentally friendly way of such treatment.
Somatic Genomic Changes in the Formation of Differentiated Thyroid Carcinoma
Authors: Vidinov K. , Dodova R. , Dimitrova I. , Mitkova A. , Shinkov A. , Kaneva R. , Kovacheva R.
Published: November 2020

Globally, the diffuse goiter affects more than 10% of the population and in some regions is endemic. Thyroid nodules are found in approximately 5% of the population using the oldest method for thyroid examination – palpation. When performing ultrasound screening, this percentage increases significantly and reaches between 20 and 75% of the total population. Thyroid carcinoma is a rare malignancy and accounts for up to 1% of all malignant tumors. It is the most common endocrine cancer and is clinically manifested as a thyroid nodule. Somatic mutations play an important role in its development. Differentiation of benign and malignant thyroid nodules is of great importance due to the different therapeutic approach. Therefore, new diagnostic tools are sought to help distinguish the two. Despite the progress in our knowledge of carcinogenesis in recent years, a number of key issues still remain unanswered. The establishment of new rare somatic mutations can improve pre-surgical diagnosis and optimize post-operative strategies for the treatment of thyroid carcinoma. Next-generation sequencing (NGS) allows for extensive mutation and genome rearrangements tracking. The results obtained with NGS provide the basis for the development of new approach for systematic genetic screening, at prevention, early diagnosis, accurate prognosis, and targeted therapy of this disorder.
The first general Zagreb coindex of graph operations
Authors: Berhe Belay Melaku , Wang Chunxiang
Published: November 2020

Many chemically important graphs can be obtained from simpler graphs by applying different graph operations. Graph operations such as union, sum, Cartesian product, composition and tensor product of graphs are among the important ones. In this paper, we introduce a new invariant which is named as the first general Zagreb coindex and defined as

M
¯

1
α

(
G
)
=

∑

uv
∈
E
(

G
¯

)

[

d
G

(
u
)

α

+

d
G

(
v
)

α

]

\overline{M}^\alpha_1(G)=\Sigma_{uv\in E(\overline{G})}[d_G(u)^\alpha+d_G(v)^\alpha]

, where α ∈ ℝ, α ≠ 0. Here, we study the basic properties of the newly introduced invariant and its behavior under some graph operations such as union, sum, Cartesian product, composition and tensor product of graphs and hence apply the results to find the first general Zagreb coindex of different important nano-structures and molecular graphs.
A Research Based On POT-CAViaR Model of Extreme Risk Measure
Authors: Zhang Baoshuai , Duan Jun
Published: November 2020

In this paper, the CAViaR model was used to measure the HS300, HSI and N225 risk levels and result showed that CAViaR model was able to measure the sample risk value at the 5% confidence level. However, at the 1% confidence level, the CAViaR model severely underestimated the sample risk value. In order to solve this question, this paper introduces the POT model and CAViaR model to construct the extreme risk measure model based on POT-CAViaR model and the test shows that the improved model can effectively improve the accuracy of extreme risk prediction and the model validity is strengthened.
When Clinical Judgement of a Heart Murmur is Wrong: A Case Report
Authors: Pop Lăcrămioara-Eliza , Butnariu Angela
Published: November 2020

Background: Infants with congenital heart defects (CHD) are at risk of death if not recognized and treated on time, desirable during intrauterine life or soon after birth. Case: A 6-week old infant presented for the evaluation of an innocent murmur, discovered immediately after birth and recorded by the neonatologist, family physician and pediatrician at follow-up visit. At physical examination, a grade 2/6 systolic murmur and tachycardia were observed. The electrocardiography revealed sinus tachycardia. Transthoracic echocardiography recorded multiple heart defects (three ventricular septal defects, an atrial septal defect, valvular regurgitations, impaired right heart function) and a vascular defect. Treatment consisted of surgical repair. Conclusions: The rarity of the case results from the atypical presentation of the cardiovascular defects only through an innocent heart murmur, therefore criteria requested by guidelines for evaluation through transthoracic echocardiography for the suspicion of a CHD, were not encountered and the diagnosis was delayed.
Endovascular Treatment for Common Iliac and External Iliac Extensive Calcification. A Case Report and Literature Review
Authors: Bloj Andrei-Florin , Mărginean Lucian , Buicu Corneliu Florin , Vunvulea Vlad
Published: November 2020

Peripheral artery disease (PAD) is an intricate and widespread pathology these days. Under some circumstances such as diabetes or other pathologies as comorbidities, PAD occurs much earlier in life. We report the case of a 55-year old male with diabetes mellitus (DM) and chronic kidney disease with extensive calcifications of the common and external iliac artery. After repeated balloon dilatation without success we resorted to placing two balloon mounted stents with optimal results.
Treatment of Hepatocellular Carcinomas by Hepatic Transarterial Chemoembolization, Case Presentation and Review of the Literature
Authors: Bloj Andrei Florin , Hălmaciu Ioana , Suciu Bogdan Andrei , Mărginean Lucian
Published: November 2020

Hepatocellular carcinoma is one of the most common liver tumours. At the time of diagnosis, only 20% of patients are suitable for liver resection for curative purposes. In patients who are not suitable for surgical resection, chemoembolization of the hepatic artery is a viable therapeutic option. We present the case of a 60-year-old male patient being admitted with a diagnosis of liver tumour in the right liver lobe. Abdominal angio-CT examination revealed the existence of a tumour formation of 9x10 cm in the liver segments IV, VIII. Given the large size of the tumour, as well as the patient’s comorbidities, it was decided to practice hepatic chemoembolization with Irinotecan. The clinical evolution was favourable, the patient being discharged 48 hours after the intervention. Hepatic transarterial chemoembolization is a viable alternative in the treatment of patients with unresectable hepatocellular carcinomas, which may improve the prognosis of these patients.
Oxytocin in Induction of Labor in Pregnancy with Group B Streptococcal Portage
Authors: Radu Mihaela Corina , Dumitrescu Anca Irina , Boeru Adrian Calin , Manolescu Loredana Sabina Cornelia , Dumitrescu Oana Roxana , Armean Petru
Published: November 2020

In the last two decades, group B streptococcus (GBS) infection has established itself as a major cause of perinatal morbidity and mortality. The purpose of this study is to identify if the electively induced labor with oxytocin in women with positive cultures of Streptococcus agalactiae, namely the group B streptococcus (GBS), helps the mother and fetus and decreases the risk associated with perinatal transmission of GBS compared with the spontaneous labor. Results associated with induction of labor with oxytocin compared with spontaneous labor in pregnant women who have GBS - positive cervical cultures, are also used to determine whether induction of labor decreases the risk of complications from GBS infection.
Maturity indices of composting plant materials with Trichoderma asperellum as activator
Authors: Komolafe Adenike Fisayo , Adejuyigbe Christopher Olu , Soretire Adeniyi Adebowale , Aiyelaagbe Isaac OreOluwa Olatokunbo
Published: November 2020

Compost maturity is a major factor in its use for nutrient supply without adverse effect on crop germination. Composting may be accelerated with inclusion of some microorganisms as activators. This study was conducted to determine the effect of Trichoderma asperellum and length of composting of different plant materials and cattle manure on compost maturity in Ibadan, Nigeria. Composting of two plant materials with cow dung at ratio 3:1 was done in triplicate with or without Trichoderma activation to obtain twelve heaps of four different types of composts; Panicum-based compost with Trichoderma, Tridax-based compost with Trichoderma, Panicum-based compost without Trichoderma and Tridax-based compost without Trichoderma. The process was a 2×2 factorial experiment, laid out a completely randomized design. The Trichoderma activated compost (TAC) at four weeks of composting (4WC) had 56% total N, 21% organic matter, 38% total K, 51% total P and 66.6% microbial biomass N increase over non-activated compost (NAC). Carbon to nitrogen ratio was within the ideal range (10–20) in TAC while it was greater than it in NAC. Microbial biomass and lignin contents had a 56% and 41% increase, respectively, in NAC over TAC. Trichorderma-activated compost has a potential to hasten maturation and makes the compost ready for field on or before four weeks without posing a threat to crop germination.
Osmotic dehydration of apple and pear slices: color and chemical characteristics
Authors: Leahu Ana , Ghinea Cristina , Oroian Mircea-Adrian
Published: November 2020

Osmotic dehydration is the pre-treatment method of preservation the fruits and vegetables to increase their shelf life. This method consists of immersing fruits and vegetables in concentrated solutions of salt or sugar. The effect of osmotic dehydration was investigated on the color and chemical characteristics of dehydrated fruits (apple and pear) in fructose osmotic solutions. Difference in CIE-LAB, chroma - C* and hue angle H* were performed with a Chroma Meter CR-400/410. Apple (Malus domestica ‘Jonathan’) and sweet autumn pear variety (Pyrus comunis) were osmotically dehydrated in three aqueous solution of fructose (40, 60 and 80%), during 3 h of process at temperatures of 20 °C, with fruit/osmotic agent ratio of 2:1. Water loss and solids gain showed significant differences depending on the concentration of the osmotic agent and process time. The use of highly concentrated osmotic solutions induced losses of phenolic content (TPC) and ascorbic acid in the sliced apples and pears. Fructose concentration and osmosis time induce significant increase of a* and b* colorimetric parameters but did not affect the lightness (L*) of pear slices.
Effect of ethanol extract of Telfairia occidentalis leaf on some biochemical parameters of 2,4-dinitrophenyl hydrazine induced oxidative stress in albino rats
Authors: Seyifunmi Oyedele Elliot , Ajayi Ayorinde
Published: November 2020

In this study, we attempt to verify the claim that the leaf-extract of Telfairia occidentalis can remedy oxidative damage condition as well as assess its phytochemical content. Fifteen male albino rats weighing 180 g to 240 g were randomly divided into three groups of five rats each. Group A was designated the control group while group B and C were both induced with 40 mg/kg body weight 2,4-dinitrophenyl hydrazine. Group C was subsequently treated with 200 mg/kg body weight of ethanol extract of T. occidentalis leaf for 21 days. At the end of the treatment, the animals were sacrificed, and serum of the samples were subjected to relevant tests. Result shows that the plant leaf contained saponin, tannins, alkaloids, flavonoids and phenols whereas, terpenes, steroids and anthraquinones were not detected. The serum enzymes alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were significantly elevated from 17.43 u/L and 28.40 u/L to 21.60 u/L and 34.27 u/L respectively. These were significantly lowered in the group C to 18.37 u/L and 29.23 u/L respectively for ALT and ALP. Also, a significant lowering of superoxide dismutase (SOD) activity was observed in the treated group (54.33 u/mg) from 79.40 u/mg recorded in the intoxicated group. Similarly, a significant decrease in malondialdehyde was observed in the treated group (25.80 u/mg) relative to the intoxicated group (35.87 u/mg). Moreover, catalase activity in the treated group (7.43 u/mg) was significantly lower compared with the intoxicated group. Our observation confirmed that ethanolic leaf extract of T. occidentalis reversed the oxidative damage condition in albino rats. The result confirms the ethnomedicinal use of the plant in the management of oxidative stress related diseases.