bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancer Morbidity as Radiation Protection Efficiency Indicator in Urainium Mining Facilities
Authors: Pavlenko T. , Operchuk A.
Published: February 2019

The paper reviews the efficience of radiation protection in uranium mining industry. The officially provided data on individual doses for underground and surface mining professionals is analysed and cancer morbity risk is assessed. The researchers defined the individual components of the total effective dose and separately assessed their contributions. The total of 114 cancer cases have been registered during the past 15 years. Accumulated equivalent doses for lungs are estimated from 20 to 430 mSv. The total working time in 56% of individual cancer cases diagnosed made over 20 years.

The actual lung cancer mortality rate for miners is established 3 cases per 1000 individuals, which permits to question the authenticity of the dosimetric data and the efficiency of radiological protection applied.
Computer Analysis of Thermomechanical State of Sealing Steel Lining for Containment of NPPs with VVER-1000/V-320 in Emergencies
Authors: Gondliakh O. , Krytskyi V. , Onopriienko V. , Chemerys A. , Krytska N.
Published: February 2019

Computer analysis of thermomechanical state of the sealing steel lining under relevant extreme hazards has been performed to define the possibility and scope of loss of integrity of sealing steel lining, in particular the possibility of losing of the confining function by the NPP reactor compartment containment under emergency conditions. The study gave an opportunity to obtain functions of stress strain parameter evolution function in reinforced concrete and sealing steel lining depending on changes in emergency temperature and pressure in the reactor compartment. The paper assessed the margin of sealing steel lining bearing capacity.
Models and Methods for Automated Control of Power Change at WWER1000
Authors: Foshch T. , Maksimov M. , Pelykh S. , Maksimova О.
Published: February 2019

Power Unit This work is devoted to the development of automated control models and methods of power change at WWER-1000 power unit to provide the most stable axial offset in the load-following mode. Improved multi-zone mathematical model of WWER1000 allows taking into account the energy release of 235U nuclei fission as well as 239Pu and includes a sub-model with distributed parameters. The automated control method of power change at WWER-1000 power unit that uses three control loops was proposed for the first time. The first loop maintains change of reactor power by controlling the boric acid concentration in the primary coolant. The second control loop maintains the required value of axial offset by controlling the position of 9th group control rods, and the third one maintains coolant temperature mode or steam pressure mode by controlling the main valve positions in the turbine generator.
Analysis of Methodological Framework for Computer Strength Justification of Steel Structures at Operating NPP Units
Authors: Krytskyi V. , Shuhailo О. , Matchenko P. , Krytska N. , Matchenko T.
Published: February 2019

Over the last decade, new national regulatory documents on the design and assessment of the technical state of building structures, in particular steel ones, have been put into force in Ukraine to replace relevant former USSR regulations. The experience of applying new national regulatory documents indicates certain incorrect provisions, which can potentially cause catastrophic consequences in case of failure of steel building structures of corresponding facilities and(or) hazardous production capacities. The paper presents the analysis of Ukrainian regulations to check compliance of available methodologies for computer strength justification of steel structures. It is established that current regulatory documents of Ukraine do not contain a description of methodologies and procedures (formulae) with regard to calculations of steel structures on resistance to brittle fracture and cyclic crack resistance. The analysis of a number of publications was performed to define methods for the calculation of steel structures to check endurance, cyclic crack resistance and resistance to brittle fracture.
Investigation of Novel Composite Material Based on Extra-Heavy Concrete and Basalt Fiber for Gamma Radiation Protection Properties
Authors: Romanenko І. , Holiuk M. , Nosovsky A. , Hulik V.
Published: February 2019

The paper presents a new composite material for radiation protection based on extra-heavy concrete reinforced by basalt fiber. Basalt fiber is a new material for concrete reinforcement, which provides improved mechanical characteristics of concrete, reduces the level of microcracks and increases the durability of concrete. Within the scope of present work, the gamma-ray radiation protection properties of concrete reinforced with basalt fiber was modeled. Two types of extra-heavy concrete were used for this paper. The main gamma-ray attenuation coefficients such as mean atomic number, mean atomic mass, mean electron density, effective atomic number, effective electron density, Murty effective atomic number were analyzed with help of WinXCom software. It has been shown that the addition of basalt fiber to concrete does not impair its gamma-ray radiation shielding properties. With increasing the basalt fiber dosage in concrete, the radiation properties against gamma radiation are improved.

This research was carried out with the financial support of the IAEA, within the terms and conditions of the Research Contract 20638 in the framework of the Coordinated Research Project (CRP) “Accelerator Driven Systems (ADS) Applications and use of Low-Enriched Uranium in ADS (T33002)” within the project “The Two-Zone Subcritical Systems with Fast and Thermal Neutron Spectra for Transmutation of Minor Actinides and Long-Lived Fission Products”.
Complexing Properties of Functional Powders
Authors: Petrova Zh. , Snezhkin Yu.
Published: February 2019

Functional products belong to the category of products that provide the human body with not only energy but also plastic substances and perform primarily the health function. The development of preventive and medical products in this area is based on the concept that envisages introduction of additives into their formulation, which meet requirements such as safety for the organism and effective binding of heavy metals (formation of strong insoluble complexes resistant to the action of enzymes in a wide range of pH). To some extent, these requirements are met by food polysaccharides contained in prebiotic functional powders. The results of in vitro studies on the binding of heavy metal ions by functional prebiotic plant powders to determine their radioprotective properties are presented in the paper. The results of research conducted using the developed drying technologies show the high complexing properties of prebiotic powders and their efficiency, greater than the efficiency of pure apple and citrus pection. Appropriate balanced nutrition using prebiotic powders in fast food products will help to reduce the risk of various diseases and remove radionuclides grom the body.
Regulatory Experience in Licensing of Alternative Supplier Fuel
Authors: Ovdiienko I. , Plachkov H. , Shevchenko I. , Dybach O. , Ieremenko M. , Shepitchak A.
Published: February 2019

At present, the diversification of nuclear fuel is ongoing at Ukrainian NPPs. The Ukrainian regulatory authority and SSTC NRS, as a technical support organization, take active part in the licensing process for introduction of new fuel assembly types. In the framework of this activity, the technical review of justification material is performed in various nuclear safety issues including a wide range of verifying calculations. Neutron kinetic, thermal-hydraulic and fuel thermal-mechanical models are developed for technical review of justification material such as safety analysis of mixed cores. The features of the developed models for safety analysis of new fuel implementation and results of their application for verifying calculations are presented in this paper. The results cover such aspects as preparation of few-group cross-section libraries with features of new FA types, calculations of transitional mixed fuel loadings up to stationary ones, verifying safety assessment for some design-basis reactivity-initiated accidents, criticality of fuel management systems and thermal-mechanical fuel behavior.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Matematika Untuk Siswa Tunarungu (SDLB-B)
Authors: Rizki Hedia , Kamid Kamid , Saharudin Saharudin
Published: February 2019

This research is aimed at describing the development of students’ worksheet of a mathematics subject for deaf students and finding out the effectivity of mathematics worksheet for deaf students toward the learning process. Multiplication is selected due to its ability to represent mathematics subject which will be developed for deaf students. This research uses research and development method (R&D) with 6 deaf subjects in grade V in special needs education Sri Soedewi Masjchun Sofwan Jambi. This research applies the ADDIE model, analysis, design, development, implementation, and evaluation. The data collected are qualitative and quantitative. Qualitative data are collected from media expert validity and learning design, material expert validity, teachers’ respond from deaf class, and questionnaire result of students’ perception of learning media which has been created. Meanwhile, quantitative data are collected from the final test. Valid students’ worksheet is based on the questionnaire administered to the validator. 79% of students’ responds show positive respond and 83,3% of learning completion. It shows that mathematics worksheet developed feasible to use in the learning process.

Keywords: Students’ worksheet (LKPD), deaf students, multiplication

Penelitian ini bertujuan untuk mendeskripsikan pengembangan LKPD matematika untuk siswa tunarungu dan mengetahui keefektivan LKPD matematika untuk siswa tunarungu terhadap pembelajaran. Materi perkalian dipilih karena dipandang mampu untuk mewakili materi matematika yang akan dikembangkan bagi anak tunarungu. Penelitian ini menggunakan metode Research and Development (R&D) dengan subjek 6 orang siswa tunarungu kelas V di SLB Negeri Sri Soedewi Masjchun Sofwan Kota Jambi. Penelitian ini menggunakan model pengembangan ADDIE, analisis,desain, pengembangan, pelaksanaan,dan evaluasi. Jenis data yang diambil yaitu data kualitatif dan data kuantitatif. Data kualitatif diperoleh dari hasil angket oleh validator ahli media dan desain pembelajaran, ahli materi, tanggapan dari guru kelas tunarungu, dan hasil angket persepsi siswa terhadap media pembelajaran yang telah dibuat. Sedangkan kuantitatif diperoleh dari  hasil belajar siswa dan tes akhir. Hasil penelitian diperoleh LKPD yang valid berdasarkan angket yang diberikan kepada validator. Untuk respon siswa diperoleh respon positif dengan hasil persentase sebesar 79% dan persentase ketuntasan belajar 83,3%. Hal ini menunjukkan bahwa LKPD matematika yang dikembangkan layak digunakan dalam proses.

Kata Kunci: Lembar Kerja Peserta Didik (LKPD), siswa tunarungu, perkalian
Pengembangan Lembar Kerja Peserta Didik (LKPD) pada Materi Geometri berbasis Budaya Jambi untuk Meningkatkan Kreativitas Siswa
Authors: Wandari Ayu , Kamid Kamid , Maison Maison
Published: February 2019

This research aims to describe the process of students’ worksheet development for math subject and find out the quality of students’ worksheet produced for geometry subject which is based on Jambi culture. This research applies research and development (R&D) method to produce a particular product. Development model applied in this research is ADDIE with 5 stages, analysis, design, development, implementation, evaluation. Subjects of this research are two validators which consist of validator of material expert, validator of design expert and students of a junior high school in grade VII. Data collected in this research are qualitative and quantitative data. Instruments used in this research are a questionnaire and a final test. The result of this study shows the development of students’ ability in mathematical representation at high category based on a gain test with 0,7 in high criteria. The result of the analysis from the questionnaire shows > 80% positive. It can be concluded that students’ worksheet for math subject is good and can improve students’ creativity. Therefore, students’ worksheet can be effectively used by both teachers and students in geometry subject.

Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan LKPD matematika dan mengetahui kualitas LKPD yang dihasilkan pada materi geometri berbasis budaya Jambi. Penelitian ini menggunakan metode Research and Development (R&D) yang digunakan untuk menghasilkan produk tertentu yaitu mengembangkan LKPD. Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan ADDIE yang terdiri dari 5 tahap yaitu analisis, desain, pengembangan, pelaksanaan, dan evaluasi. Subjek penelitian pada pengembangan ini adalah dua orang validator yang terdiri dari validator uji ahli materi, validator uji ahli desain dan media, dan juga sasaran pemakai dari produk ini adalah siswa kelas VII SMP. Jenis data yang diambil dalam penelitian ini berupa data kualitatif dan data kuantitatif. Instrumen yang digunakan pada penelitian adalah angket dan tes hasil belajar. Hasil penelitian diperoleh  peningkatan kemampuan representasi matematis siswa pada kategori tinggi berdasarkan uji gain terlihat skor yang didapat 0,7 berada pada kriteria tinggi. Dan hasil analisis dari angket persepsi siswa didapat persentase > 80% yang dinyatakan sangat positif. Dapat disimpulkan LKPD matematika yang dikembangkan sangat baik dan dapat meningkatkan kreativitas siswa sehingga LKPD efektif digunakan oleh guru dan siswa SMP khususnya pada materi geometri.
Eksplorasi Etnomatematika pada Alat Musik Gordang Sambilan
Authors: Lubis Sofia Indriani , Mujib Abdul , Siregar Hasratuddin
Published: February 2019

Budaya merupakan suatu kebiasaan yang mengandung unsur-unsur nilai penting dan fundamental serta dekat dengan kehidupan manusia dan diwariskan dari generasi ke generasi. Budaya dapat dijadikan sebagai media pembelajaran bagi siswa disekolah sekaligus mempelajari budaya itu sendiri. Mandailing merupakan salah satu etnik dari Sumatera Utara yang memiliki budaya adat istiadat, warisan, tradisi yang khas, dan berbeda dengan kebudayaan lain yang harus dilestarikan. Salah satu kebudayaan mandailing adalah Gordang Sambilan yaitu alat musik tradisional yang terdiri dari sembilan gendang dengan tinggi dan diameter yang berbeda sehingga menghasilkan nada yang berbeda dan dimainkan oleh 5-6 orang pemain. Tujuan dari penelitian ini untuk mengeksplorasikan konsep matematika apa saja yang ada pada alat musik Gordang Sambilan sehingga dapat diimplementasikan pada pembelajaran matematika di dalam kelas. Jenis penelitian ini adalah penelitian kualitatif yang bersifat eksploratif tentang alat musik Gordang Sambilan. Hasil dari penelitian ini menunjukkan bahwa terdapat beberapa jenis konsep barisan aritmatika dan konsep geometri.
Implications of the Application of Flipped Classroom Learning Media to Self-efficacy and Student Learning Participant
Authors: EBGC Hesty Prima Rini , EBGC Wilma Cordelia Izaak
Published: February 2019

The importance of learning activeness of UPN Veteran Jawa Timur management program students in the success of the learning process, one of which is influenced by internal factors inherent in students (talents, interests, and IQ), one of which is shown by the level of self-efficacy. This study aims to analyze the implications of application of flipped class room learning media to increase self-efficacy and student learning activities. This research uses quasi experiment or pseudo experiment with one-group-pretest-posttest design model, where the research will be conducted in two cycles of assessment that is the first cycle in the period before the learning process "Interactive Classroom Activities" and "Explicit Instruction Methods" after seven initial meetings before Midtest and after Midtest. This research process is done cyclically as suggested by Kemmis & McTaggart (1988) with respect to plan, implementation, monitoring, and reflection. Test reliability is done by technique test-retest (repeat measurement). The population in this study are all students of Management Faculty of Economics and Business UPN Veteran Jawa Timur. The sample in this research is student of UPN Veteran Jawa Timur Management class of 2015-2016 as experiment class with number of 30 people. Based on the classroom action research conducted by the influence of self-efficacy on student activity, the effect of using flipped classroom learning media on self-efficacy in two different cycles proved to have positive but not significant effect. Second, the influence of the use of flipped classroom learning media visually proved to have a positive and significant impact on student activeness.
The Influence of Targeted Profitability and Company Size to Income Smoothing
Authors: EBGC Izzaty Choirina Mudjiumami , EBGC Yuvico MR Setiawan
Published: February 2019

This research purpose is to know the influence of targeted profitability and company size to income smoothing in manufacture companies listed at Bursa Efek Indonesia period 2015-2017. Method that used for sample target is purposive sampling method. Population of this research are 57 manufacture companies listed at Bursa Efek Indonesia period 2015-2017 which already fulfill the sample criteria that used in this research. To identify companies that did income smoothing practical with using Eckel Index. Result from Eckel Index shown that income smoothing practical also did by a certain companies listed in Bursa Efek Indonesia. Statistic method using multiple linear regression, which are; multicollinearity testing, heteroscedasticity testing, autocorrelation testing, and normality testing. Testing did to proof any significant influence targeted profitability and company size to income smoothing. Research result shown that there is no influence of targeted profitability and company size to income smoothing in manufacture companies listed in Bursa Efek Indonesia period 2015-2017.
Satisfaction and Loyalty of Honda Motorcycle Consumers in Jember
Authors: EBGC Reiga Ritomiea Ariescy
Published: February 2019

This research aims to analyze the effect of price and product quality on satisfaction and loyalty of Honda motorcycle customers in Jember. The research design is confirmatory research. The research population is all customers of Honda motorcycles in Jember, and then researcher take 114 sample. Researcher take respondents used non-probability sampling techniques with purposive sampling approach. Analysis tool used Structural Equation Modeling (SEM). The results of this research prove that product quality has a significant effect on customer loyalty. Product quality also has a significant effect on customer loyalty. Price does not effect on customer satisfaction, but price has a significant effect on customer loyalty. Customer satisfaction has a significant effect on customer loyalty.
An Opportunity: Growing of Financial Technology to Stimulate Sharing Economy in East Java
Authors: EBGC Alfiandi Imam Mawardi
Published: February 2019

This paper analyzes the phenomenon of financial technology starts to change conventional financial institution for helping economic development, which the financial technology more likely start-up company is the innovative solution of funding on this country. Financial technology on online-based business offers new opportunities, new investment trends and new funding resources such as lending and capital rising, wealth management and insurance, payment and financial research. I apply generalized method of moment approach on startup company data on financial technology that shows business models and the result shows that financial technology can synergy with financial institution will increase the sharing economy in East Java. Under a competitive industry, financial technology should improve their accountability, accessibility, and reliability to persuade other start-up businesses to growth up together. This paper explains what existing financial technology business model to help start-up business in Indonesia today and how financial technologies to realize good sharing economy in this East Java.
ANALISIS KEMAMPUAN KOGNITIF PEMECAHAN MASALAH ANAK DALAM BERMAIN BALOK
Authors: Ratna Wahyu Pusari Farida Nur Utami,
Published: February 2019

Pendidikan Anak Usia Dini adalah upaya pembinaan yang ditujukan kepada anak sejak lahir sampai usia enam tahun yang dilakukan melalui pemberian rancangan pendidikan untuk membantu pertumbuhan dan perkembangan jasmani dan rohani agar anak memiliki kesiapan dalam memasuki pendidikan lebih lanjut. Mengenai perkembangan kognitif, anak pada rentang usia ini masuk dalam perkembangan berpikir praoperasional konkret. Pada saat ini sifat egosentris anak semakin nyata. Anak mulai memiliki perspektif yang berbeda degan orang lain yang berada di sekitarnya. Perkembangan kognitif merupakan salah satu aspek yang penting untuk dikembangkan pada anak usia dini. Pemecahan masalah sebagai suatu proses banyak langkah dengan si pemecah masalah harus menemukan hubungan antara pengalaman (skema) masa lalunya dengan masalah yang sekarang dihadapinya dan kemudian bertindak untuk menjelaskan. Fokus dalam penelitian ini adalah analisis perkembangan kognitif pemecahan masalah anak dalam bermain balok dengan tujuan untuk mendeskripsikan kemampuan kognitif pemecahan masalah anak. Penelitian ini menggunakan penelitian kualitatif, penelitian kualitatif adalah metode penelitian yang berlandaskan pada filsafat postpositivisme, digunakan untuk meneliti kondisi obyek yang bersifat alamiah. Metode pengumpulan data menggunakan observasi, dokumentasi, dan wawancara. Teknik analisis data menggunakan pengumpulan data, seleksi data, menyajikan dan penerikan kesimpulan. Hasil penelitian menunjukkan ada beberapa tahapan dalam memecahkan masalah yang harus diselesaikan anak dalam bermain balok, yaitu membaca dan berfikir, mengeksplorasi dan merencanakan, memilih strategi, mencari jawaban, refleksi dan mengembangkan. Saran yang peneliti berikan kepada guru adalah memberikan kesempatan kepada anak untuk menyelesaikan masalahnya terlebih dahulu tanpa harus memberi bantuan dan juga saran untuk sekolah yakni memberikan ruang yang cukup luas saat anak bermain membangun.
UPAYA MENINGKATKAN KREATIVITAS ANAK MELALUI METODE MOZAIK DENGAN BIJI-BIJIAN DI KELOMPOK B TK DHARMA WANITA CARUBAN KECAMATAN KANDANGAN KABUPATEN TEMANGGUNG
Authors: Rusmiyati Rusmiyati
Published: February 2019

Tujuan dari penelitian ini adalah : 1) untuk mengetahui bahwa metode mozaik dengan biji-bijian dapat meningkatkan kreativitas anak, 2) untuk mengetahui besarnya peningatan kreativitas anak melalui metode mozaik dengan biji-bijian pada anak Kelompok B TK Dharma Wanita Caruban Kandangan Semester I Tahun Pelajaran 2017/2018. Metode penelitian yang digunakan adalah penelitian tindakan kelas dengan metode pengumpulan data yang digunakan adalah observasi, dokumentasi dan wawancara. Berdasarkan hasil penelitian dan pembahasan, maka dapat disimpulkan bahwa melalui metode mozaik dengan biji-bijian terbukti efektif dapat meningkatkan kreativitas belajar anak di Kelompok B TK Dharma Wanita Caruban Kandangan Temanggung Semester I Tahun Pelajaran 2017/2018. Hal ini dibuktikan dengan adanya peningkatan kreativitas anak sebelum tindakan hanya mencapai 10%, kemudian setelah diadakan perbaikan pada Siklus I meningkat menjadi 35%, dan Siklus II menjadi 85%, telah memenuhi persentase maksimum yang telah ditentukan yaitu 80%. Keberhasilan ini ditandai dengan anak mampu mengisi pola menempel dengan biji-bijian, ketepatan dan kerapian dalam menempel, menceritakan hasil karya yang dibuatnya.
A New Perspective for Saturation Flows at Signalized Intersections
Authors: Murat Yetis Sazi , Cetin Murat
Published: February 2019

Saturation flow is one of the fundamental parameter that is used to define the level of service, to assign signal timings and other traffic operations. In the conventional approaches (Highway Capacity Manual, Canadian Capacity Guide etc.) base value is adjusted by the parameters that represent field and traffic conditions. Although the results obtained are acceptable, the adjustment parameters may not reflect the field conditions properly in many countries and does not represent any effects on driver behavior. This paper presents a new formula for saturation flow based on driver behavior and some vehicle characteristics. In this formula, mean length, headway and acceleration rates of vehicles, saturation speeds of intersection and mean reaction time of vehicles in a queue are considered. The formula is tested with field data and compared to the values obtained by the HCM, CCG (Canadian Capacity Guide) and the Akcelik approaches. Based on these comparisons, it is commented that estimation of the new formula is promising.
A Survey on Text-based Modeling in Model Evolution and Management
Authors: Somogyi Ferenc A. , Asztalos Mark
Published: February 2019

Model-driven software engineering methodologies like model-driven engineering aim to improve the productivity of software development by using graph-based models as the main artifacts during development, and generating the source code from these models. The models are usually displayed and edited using a graphical notation. However, they can also be described using a textual notation. This has some advantages and disadvantages compared to the graphical approach. For example, while editing the model, we can better focus on the details instead of a broad overview. Similarly to source code, models evolve rapidly during development. Handling and managing the evolution of models is an important task in model-driven methodologies and is an active research area today. However, there exist few research on text-based modeling approaches, compared to graph-based ones. This paper introduces the text-based modeling research field based on existing literature, and presents the state-of-the-art of the field related to model evolution and management. Our goal is to identify challenges and directions for future research in this field. The main topics covered are model differencing and merging, and the synchronization of the textual and graphical notations.
Cellular Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging and Super-resolution Microscopy
Authors: Maji Dolonchampa , Lu Jin , Sarder Pinaki , Schmieder Anne H , Cui Grace , Yang Xiaoxia , Pan Dipanjan , Achilefu Samuel , Lanza Gregory M
Published: February 2019

While the in vivoefficacy of Sn-2 phosphatidylcholine prodrugs incorporated into targeted, non-pegylated lipid-encapsulated nanoparticles was demonstrated in prior preclinical studies, the microscopic details of cell prodrug internalization and trafficking events are unknown. Classic fluorescence microscopy, fluorescence lifetime imaging microscopy, and single-molecule super-resolution microscopy were used to investigate the cellular handling of doxorubicin-prodrug and AlexaFluor-488-prodrug. Sn-2 phosphatidylcholine prodrugs delivered by hemifusion of nanoparticle and cell phospholipid membranes functioned as phosphatidylcholine mimics, circumventing the challenges of endosome sequestration and release. Phosphatidylcholine prodrugs in the outer cell membrane leaflet translocated to the inner membrane leaflet by ATP-dependent and ATP-independent mechanisms and distributed broadly within the cytosolic membranes over the next 12 h. A portion of the phosphatidylcholine prodrug populated vesicle membranes trafficked to the perinuclear Golgi/ER region, where the drug was enzymatically liberated and activated. Native doxorubicin entered the cells, passed rapidly to the nucleus, and bound to dsDNA, whereas DOX was first enzymatically liberated from DOX-prodrug within the cytosol,particularly in the perinuclear region, before binding nuclear dsDNA. Much of DOX-prodrug was initially retained within intracellular membranes. In vitroanti-proliferation effectiveness of the two drug delivery approaches was equivalent at 48 h, suggesting that residual intracellular DOX-prodrug may constitute a slow-release drug reservoir that enhances effectiveness. We have demonstrated thatSn-2 phosphatidylcholine prodrugs function as phosphatidylcholine mimics following reported pathways of phosphatidylcholine distribution and metabolism. Drug complexed to the Sn-2 fatty acid is enzymatically liberated and reactivated over many hours, which may enhance efficacy over time.
Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury
Authors: Yan Huimin , Duan Xin , Collins Kelsey H , Springer Luke E , Guilak Farshid , Wickline Samuel A , Rai M Farook , Pan Hua , Pham Christine ,   Washington University School of Medicine,   Washington University School of Medicine,   University of South Florida Health Heart Institute, Morsani School of Medicine,   University of South Florida Health Heart Institute, Morsani School of Medicine
Published: February 2019

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-κB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progression of post-traumatic osteoarthritis.
The potential utility of iron oxide nanoparticles for the treatment of skin inflammation in a mouse model of psoriasis
Authors: Shah Ankit , Cedrone Edward , Sanders Chelsea E , Butcher Donna , DeFrancesco Alexandra M , DeGrange Casey L , Difilippantonio Simone , Edmondson Elijah F , Dobrovolskaia Marina ,   Nanotechnology Characterization Laboratory,   Frederick National Laboratory for Cancer Research,   Frederick National Laboratory for Cancer Research,   Frederick National Laboratory for Cancer Research
Published: February 2019

Several studies have demonstrated that immunosuppressive effects accompany systemic administration of some iron oxide nanoparticles (IONPs). In our earlier study, conducted using human peripheral blood mononuclear cells, we showed that therapeutic formulation of IONPs, Feraheme, approved for clinical use in the United States for the treatment of iron deficiency in chronic kidney disease, suppresses the function of activated T-cells in vitro via a mechanism involving mitochondrial damage. Here we report an in vivo study demonstrating that topical application of Feraheme prior to disease onset decreases the development of skin lesions in the mouse model of chemically induced psoriasis.
Trust Giving Transactions on Mu'amalah Al-Wadi'ah
Authors: Bahri Saiful , Syarkawi Syarkawi , Mursal Mursal , Fizazuawil Fizazuawil , Maimun Maimun
Published: February 2019

The practice of mu'amalah al-Wadi'ah in Indonesian is often termed by liter literary savings, which is currently underway among the people through  Bakn Syari'ah institution. Definition of wadi'ah, even though there is a diversity of editors in the formulation of the meaning, but substantially does not show fundamental differences, it's just that there are editorial differences between including and representing. So it can be understood that wadi'ah is giving power to someone who is trusted to maintain certain assets in a certain way. The legal basis for Wadiah is found in Qur'an, Surat al-Nisa verse: 58, and Surat al-Baqarah, verse: 283. Besides that, there is also a legal basis in the hadith, a History of the abi of David, and the ijmak of the scholars.
Need The Preservation of New as Well as old Antibiotics
Authors: Rahman AKM Shahidur
Published: February 2019

Abstract not available

KYAMC Journal Vol. 9, No.-4, January 2019, Page 142-143
Initial Experience of Open Radical Retropubic Prostatecomy With 5 Cases
Authors: Belal Md Towhid , Rahman Md Mostafizur , Chowdhury Tanvir Ahmed , Hossain Md. Shamim , Chowdhury Md Shafiqul Alam , Rasul Md Amanur , Islam Md Kamrul
Published: February 2019

Background: Radical prostatectomy is the best treatment option for clinically localized prostate cancer. But oncological as well as functional outcomes of this procedure including incontinence and erectile dysfunction are a big challenge for the surgeon.

Objectives: This paper has focused on our initial experiences of oncological and functional outcomes of open radical retropubic prostatectomy.

Materials and methods: Total five cases underwent open radical retropubic prostatectomy between January'2016 to October' 2017. All patients had clinically organ confined prostatic adenocarcinoma. Open radical retropubic prostatectomy with bilateral pelvic lymph node dissection was done through a lower midline incision. We observed the surgical experiences and assess the oncological and functional outcomes postoperatively.

Results: The median age (range) of patients at diagnosis was 63 (56-72) years. The median Gleason sum (range) was 7 (6-9) and mean pretreatment PSA was 16.2±5.4 ng/ml. There was no perioperative mortality and no major complications in immediate postoperative period. Final pathological specimen shows negative surgical margin in all cases but one patient has positive unilateral lymph nodes. One patient achieved continence within 3 months; three patients achieved continence at 6 months, one patient after one year. Two patients had satisfactory erection at 6 months; onepatients are at 9 months, and two patients could not gain erection after one year.

Conclusion: Though open radical retropubic prostatectomy is tough procedure due to its difficult access to the surgical field. Oncological and functional outcome is totally depending on the skill of the surgical team.

KYAMC Journal Vol. 9, No.-4, January 2019, Page 166-169
Management of Malignant Pleural Effusions
Authors: Rahman Md Lutfar , Rahman Mohammad Arifur , Ahmed Nizam Uddin
Published: February 2019

Malignant pleural effusions (MPE) are a common clinical problem in patients with neoplastic disease. In adults, 95% of neoplastic pleural effusions arise from a metastatic source, with lung and breast carcinoma accounting for 75% of all cases. Median survival following diagnosis ranges from 3 to 12 months and is dependent on the stage and type of the underlying malignancy. Most pleural metastases arise from tumor emboli to the visceral pleural surface, with secondary seeding to the parietal pleura. Other possible mechanisms include direct tumor invasion, hematogenous spread to parietal pleura, and lymphatic involvement. Dyspnoea is the most common presenting symptom and is occasionally accompanied by chest pain and cough. Chest radiographs confirm the size and location of the pleural collection. Thoracocentesis is usually diagnostic and also therapeutic. Exudative and hemorrhagic collections should be considered metastatic until proved otherwise. Various modalities are available in the management of MPE. Careful consideration of the patient's expected survival and quality of life is needed when deciding the optimum treatment modality in such patients.

KYAMC Journal Vol. 9, No.-4, January 2019, Page 182-189
Efektifitas Kepemimpinan Lembaga Pendidikan Islam di Pesantren
Authors: Arifin Zaenal
Published: February 2019

Artikel ini membahas bagaimana efektifitas kepemimpinan lembaga pendidikan Islam konteks pesantren (khususnya di Jawa). Pesantren merupakan lembaga pendidikan Islam yang memiliki perbedaan yang sangat mencolok dibandingkan dengan lembaga pendidikan Islam selainnya. Diantara perbedaan tersebut ialah fenomena perilaku kepemimpinan yang dianut oleh pesantren, dimana kepemimpinan pesantren sangat terkesan ottoriter-patternalistik, yaitu kepemimpinan yang semua keputusannya terpusat pada fatwa seorang kyai dan hubungan kyai dan bawahan menunjukkan sifat kekerabatan.

Kerangka teoritik sebagai pisau analisis dalam artikel ini adalah pendekatan manajerial grid, dimana kepemimpinan berkecenderungan pada dua hal, yakni hasil produksi di satu pihak dan kelompok organisasi di pihak lain.

Perilaku kepemimpinan yang dijalankan oleh seorang pemimpin pesantren cenderung menggunakan model kepemimpinan ini tergolong pada perilaku kepemimpinan yang cenderung rendah perhatiannya pada hasil sekaligus rendah perhatiannya pada kekompakan anggota. Sehingga secara rasional perilaku kepemimpinan ini sangat kurang efektif.
Madu sebagai Terapi Komplementer untuk Anak dengan Diare Akut
Authors: Rokhaidah Rokhaidah
Published: February 2019

Abstrak
 
Diare merupakan suatu penyakit endemis di Indonesia yang berpotensi menjadi Kejadian Luar Biasa (KLB) yang sering disertai dengan kematian. Penanganan diare selain menggunakan teknik farmakoterapi terdapat juga terapi komplementer yang dapat digunakan yaitu dengan memberikan madu.. Manfaat madu untuk mengatasi diare karena efek antibakterinya dan kandungan nutrisinya yang mudah dicerna. Madu  juga  membantu dalam penggantian cairan tubuh yang hilang akibat diare. Tujuan penelitian ini  untuk menganalisis pengaruh madu terhadap diare akut pada anak balita. Metode penelitian yang digunakan adalah quasi eksperimental dengan Pretest and posttest non equivalent control group design. Hipotesis penelitian ini adalah terdapat pengeruh madu terhadap frekuensi buang air besar (BAB) dan karakteristik feses pada anak balita dengan diare akut.. Hasil penelitian ini menunjukkan perbedaan yang signifikan frekuensi BAB dan konsistensi feses  sebelum dan sesudah pemberian madu  (p value = 0,001) sehingga dapat disimpulkan bahwa madu berpengaruh terhadap frekuensi BAB dan konsistensi feses pada anak balita dengan diare akut.
THE EFFECTIVENESS OF EXPAND GAMA TOWARD STUDENTS’ MOTIVATION IN LEARNING GRAMMAR
Authors: Wardiah Lailatul
Published: February 2019

This research was aimed to find out whether the use of expand game effective toward students’ motivation in learning grammar and to find out correlation between students’ motivation and grammar. The kind of this research was experimental research with pre test and post test design. The population of this research was the students at the second grade students of of MTs Al-Muslimun NW Tegal consist of 104 students. The sample of this research used two classes namely experimental group and control group where each group consisted of 26 students. The sample technique used in this research was cluster random sampling by using lottery. The experimental was taught by expand game and control group taught by puzzle game. The instruments that used were grammar test and questionnaire for the motivation. The data analyzed used t-test. The result of the analyzed showed that the value of to (t obtained) 3.50 was higher than tt (t table) 2.056, the significant level 0.05. Based on the result of the study, it could be concluded that the use of expand game effective in learning grammar at the Second Grade Students of MTs Al-Muslimun NW Tegal and the result correlation between students’ motivation and grammar showed r-test was higher than r-table (0.979 > 0.388). Based on the result of the study, it could be concluded that is correlation between students’ motivation and grammar is accepted. In other word, alternative hypothesis (Ha) was accepted and null hypothesis (Ho) was rejected.
THE INFLUENCE OF THE PYRAMID DISCUSSION TOWARDS THE STUDENT WRITING ABILITY
Authors: Nullah Nazhan
Published: February 2019

This research was aimed to know whether the " Pyramid Discussion" can give a significant influence toward the students' writing skill at the second year students’ of SMA Darul Hikmah in the Academic Year of 2016/2017. The research design of this study was pre-experimental design with pre-test and post-test one group only. The population of this research was the second grade student of SMA Darul Hikmah Mataram in the Academic Year of 2016/2017 that consist of 33 students with 18 males and 15 females students. Meanwhile, the instrument of this research was pre-writing test. The technique of data analysis were descriptive analysis and inferential analysis. Based on the result of the data analysis as the mean score of pre-test was 22.5 and the mean score of post-test was 28.2 Whereas the score of t-test was 9.24 the score of t-table was 1.68 with 32 of freedom degree it was the confidence level of 0.05 or 90% the findings indicated that the value of t-test was higher than the value of t-table (9.24 >1.684). The conclusion of this research showed that " Pyramid Discussion" was significantly influenced the students' writing skill at the second year students’ of SMA Darul Hikmah in the Academic Year of 2016/2017. It can be conferred that the null hypothesis (Ho) was  rejected and therefore the alternative hypothesis (Ha) was accepted. Finally the researcher may conclude that the use of pyramid discussion in teaching writing was significantly influenced.
FACTORS AFFECTING STUDENTS’ CONFIDENCE IN PUBLIC SPEAKING
Authors: Pratama Muhammad Arif
Published: February 2019

The researcher aimed to find out an internal and external factors that affected students’ confidence in public speaking performance. The kind of this research was qualitative, this study is dealing with Miles and Huberman theory, the sample of this research was consist 5 members, the technique of collecting data used recording, note taking and questionnaires which was consit of 5 items and each item consisted of four options (very agree, agree, disagree, very disagree). The technique of data analysis used reduction, display, veryfiying the data for recording and note taking, meanwhile for questionnaires the researcher was used tabulation, computation and clarifiying the internal and external factors that affect students’ confidence in public speaking performance.
TYPICAL METHODOLOGICAL FAILURES DEMONSTRATED BY STUDENTS OF TEACHERS’ COLLEGE IN CONDUCTING CLASSROOM ACTION RESEARCH
Authors: Irawan Lalu Ari
Published: February 2019

Conducting a research is a compulsory skill to be accomplished by any teacher students of English language teaching (ELT) department in teacher’s college. As a minimum requirement, each teacher-student must have experience to conduct a sophisticated Classroom Action Research (CAR). Within this skill, a teacher-student is expected to grasp various challenges that may occur in learning, therefore to take necessary actions in order to improve the quality of learning. Hence, this paper is composed due to an assumption occurred in a preliminary study that students in English language teaching department have demonstrated numbers of methodologically failures in conducting CARs. This assumption stimulates a question to answer further, “What sorts of methodologically failures are demonstrated by teacher’s college students in conducting CARs?” Researchers as the main instrument in this study develop theoretical criteria form based on prominent works of Susanto (2010), Hult and Lennung (1980), McKernan (1991), Kemmis and McTaggart (1992), Winter’s (1996), andMcNiff (2002) to frame the analysis. Data is taken from selected works stored in a library of a teacher’s college in Nusa Tenggara Barat, by employing two criteria to students’ works (mini-thesis), i.e. year of publication is 2015 and marked with ‘A’ from internal examination board of the college. These criteria constrain only two scripts to be further analyzed. By applying content analysis, this study reveals various kinds of methodological failure in students’ works about CAR, i.e. (1) violation to collaborative principle of CAR, (2) violation to the four characteristics of CAR (situational, participatory, evaluative, and cooperative), (3) the use of learners’ achievement as benchmark of success, (4) developed in quantitative study, (5) failure in positioning the researcher as a teacher or collaborator, and (6) failure in the construction of lesson plans.
THE EFFECTIVENESS OF USING ENGLISH MOVIE WITH ENGLISH SUBTITTLES IN TEACHING VOCABULARY AT THE EIGHTH YEAR STUDENTS OFSMPN 1SELONG IN THE ACADEMIC YEAR OF 2018/2019
Authors: Lail Husnul
Published: February 2019

This investigation was aimed to identify the effectiveness of using English movie with English subtitles in teaching vocabulary in the form comprehension of descriptive text at the eighth year students of SMPN 1 Selong Lombok Timur in the academic year of2018/2019. Learning out comes in this research included learning achievement in the form of cognitive skill and vocabulary mastery. This research was a quasi-experimental research. The population is the whole class VIIISMPN1Selong. Sampling was done by random sampling technique for the population in the unit class. Samples of study were class VIIIA as a control class that uses conventional teaching (lectures) and VIIIB as an experimental class that use media movie with subtitles. The data were obtained through pre test to know the students’ ability. Statistical test used to test the hypothesis was Mann Whitney U test with a normal curve approach Z performed on the data post-test. Data post-test showed at the 0.05significance level, the value of Z table=1.99, and Z count (3.25)>Z table (1.99). Because Z count is greater than Z table, then Ha accepted and Ho is rejected. It was found that the result of this research was the using of media movie with English subtitles was effective in increasing knowledge of vocabulary in class VIII SMAN 1Selong Lombok Timur in the academic year of 2018/2019.
Kombinasi Kriptografi RSA dengan Linear Congruential Generator
Authors: Harahap Muhammad Khoiruddin , Rina Rina
Published: February 2019

Kriptografi menjadi sebuah teknik keamanan yang terus berkembang dan tak pernah selesai dalam pembahasannya. Keamanan terhadap data juga selalu menjadi perhatian yang sangat penting demi untuk menjaga kerahasiaan dan keamanan dari data tersebut. Dalam pembahasan ini bertujuan untuk menggabungkan dua buah algoritma yaitu pembangkit bilangan acak menggunakan metode Linear Congruential Generator untuk membuat tabel baru index bilangan ASCII yang kemudian dilanjutkan dengan Enkripsi / dekripsi menggunakan RSA. Melalui pembahasan tersebut didapatkanlah keamanan data menjadi 2 layer, yaitu layer pertama berdasarkan pengacakan code ASCII menjadi tabel baru dan Layer Kedua Enkripsi dan Dekripsi menggunakan metode RSA
ASSESSMENT OF TEMPORAL TRENDS OF MALIGNANT NEOPLASMS INCIDENCE USING MULTIVARIABLE STATISTICAL ANALYSIS
Authors: Emtseva E D , Kiku P F , Mazelis A L
Published: February 2019

The article presents the results of the assessment of the trends of malignant neoplasms incidence in Russian regions using multivariable statistics. The study was performed using cluster analysis and panel data models for the data on cancer incidence for all 78 Russian regions for the period from 2005 to 2015. RStudio package was used for all calculations. Data on all independent variables were collected from the official state statistics. Cluster analysis and modeling methods taking into account the panel structure of data makes it possible to study associations between environmental indicators and the incidence of cancers or so-called oncoepidemiological process. The proposed method of multivariable analysis of medical and statistical indicators contributes to the field of data processing for medical and environmental monitoring.