bluuebunny/crossref_metadata_2025 huggingface dataset:
Vortex γ rays from scattering laser bullets off ultrarelativistic electrons
Authors: Liu Yang-Yang , Salamin Yousef I. , Dou Zhen-Ke , Xu Zhong-Feng , Li Jian-Xing
Published: January 2020

Generation of high-flux vortex

γ

-ray pulses is investigated in the interaction of ultraintense Bessel–Bessel laser bullets colliding head-on with ultrarelativistic electron bunches in the quantum radiation-dominated regime. In the simulations, a semiclassical Monte–Carlo method is used, based on the radiation probabilities in the local constant field approximation, to describe the electron motion and emission of radiation. Characteristics of the driving laser pulse (orbital angular momentum and nondiffracting spatial and temporal structures) are transferred to the emitted

γ

rays by nonlinear Compton scattering.
Cultural homestay enterprises: Sustainability factors in Kiangan, Ifugao
Authors: Escolar-Jimenez Caryl Charlene
Published: January 2020

This article contributes to the continuing discussion about the community-based tradition of sustainability in small tourism enterprises. An analysis is made of cultural homestay enterprises at a UNESCO World Heritage town in Kiangan, Ifugao as it examines the standardized nature and the effect of the regionalized homestay identity of the Association of Southeast Asian Nations (ASEAN). The findings revealed that regional organizations in the ASEAN have focused on improving their competitiveness by marketing homestay tourism product globally. Homestay operations in the region which are holistic in strategy are the 'hard' factors that monitor and systematize the process, while closely related factors arising from culture are said to be the 'soft' elements. The subsequent overlap of the two affect the local enterprises as a whole and consequently promote further homestay tourism. An important implication from these findings are the three foundation variables of cultural tradition and heritage, cultural identity and infrastructure ventilation that is specific to the Philippines. The stronger, embedded and authentic these foundation variables are, the more successful and profitable these small tourism firms will be as this equates to tourist arrivals.
La relación enfermera-paciente: identidad histórica, metodológica y terapéutica en los cuidados de enfermería
Authors: Allamde Cusso Regina , Macías Seda Juana , Porcel Gálvez Ana María
Published: January 2020

Introducción: La relación enfermera-paciente permite desarrollar el cuidado enfermero, siendo el contexto en el que se da una interacción entre ambos con el objetivo de ejecutar un plan de cuidados y conseguir resultados en saludObjetivo: Reflexionar acerca de a la identidad e importancia de la relación enfermera-paciente en los cuidados de enfermería.Método: Análisis teórico reflexivo acerca de la identidad de la relación enfermera-paciente desde una perspectiva fundamental, metodológica y clínica en los cuidados de enfermería.Resultado: La discusión argumenta el interés de la relación enfermera-paciente como objeto de estudio desde los inicios de la disciplina, así como su importancia en todos los procesos metodológicos que subyacen a los cuidados enfermeros, y las consecuencias terapéuticas de la misma sobre la situación de salud del paciente.Conclusión: La relación enfermera-paciente permite desarrollar el cuidado enfermero, y su importancia y presencia en los cuidados enfermeros la identifican como un pilar básico para el desarrollo del mismo en todas sus dimensiones.
Estudio etnográfico sobre la dramatización de la alegría por clases sociales y del estigma en los adultos de la tercera edad del Asilo San Antonio (Colombia)
Authors: Romero Tenorio José Manuel , Cabrera Izquierdo Lorena , Díez Jiménez Adriano
Published: January 2020

Objetivo: Analizar las interacciones sociales de los internos del asilo San Antonio (Barranquilla) desde la perspectiva dramática, con el fin de entender los mecanismos por medio de los cuales asumen sus estigmas para acomodarse al sistema. Metodología: Etnografía interaccionista de corte analítico. Se recogió la información por medio de observación participante, notas de campo, registro fotográfico y 22 entrevistas en profundidad a informantes clave. La información, previamente organizada en unidades de registro, contexto y categorías, se sometió a un análisis crítico del discurso para hallar patrones de relevancia que sirvieron para desarrollar, analíticamente, los resultados en cinco ejes. Resultados: se identificaron cinco estrategias dramáticas por medio de las cuales los internos del asilo incorporan los estigmas en aras de complacer tácticamente al sistema: la presencia de los propios investigadores como agentes estigmatizadores, la obediencia atribuida, la excesiva trasparencia identitaria como enfermo, la autoimposición del estigma y el edadismo estratégico. Conclusiones: Los internos del Asilo San Antonio terminan por participar de su propio sometimiento, incorporando los estigmas que le son atribuidos por el sistema. Abogamos por desarrollar una visión cultural humanista de los cuidados que restituya, al espacio de atención a personas sensibles, su valor antropológico, para que prevalezca sobre los procedimientos institucionales.
Review Onã Silva (2019). The Fantastic Cordel Journey Through Nursing History. Brasilia: Editorial Cuidarte, pp.304
Authors: Silva Onã
Published: January 2020

El fantástico viaje de Cordel a través de la historia de la enfermería, constituye uma nueva incursión de Onã Silva en el género de la literatura de cordel y lo hace, de nuevo, con fines didácticos para facilitar la enseñanza de la historia de la enfermería.
Reseña Ana María Marcos y Javier de la Torre (editores) (2019). Y de nuevo la eutanasia. Una mirada nacional e internacional. Madrid: Dykinson
Authors: Ramos pozón Sergio
Published: January 2020

En este libro, los autores realizan una exposición sobre el suicidio asistido y la eutanasia en los distintos países y estados en los que se han despenalizado. Se desea exponer la realidad ética y legal, y cuáles son los desafíos y peligros de estas prácticas clínica. ISBN: 978-84-1324-036-7.
Ideas políticas en algunas obras lexicográficas monolingües del siglo XIX: en torno a lo liberal y lo nacional
Authors: Raab Matthias
Published: January 2020

En el presente trabajo, se estudia el tratamiento lexicográfico que reciben las voces relativas a las ideas políticas incipientes del liberalismo y nacionalismo a lo largo del siglo XIX. Para ello, se rastrearán los cambios destacados en los artículos lexicográficos correspondientes a los términos liberal, libertad y liberalismo, por un lado; y nación, nacional, nacionalidad y nacionalismo, por otro, teniendo en cuenta tanto las obras lexicográficas de la Real Academia Española como los diccionarios no académicos más sobresalientes que se publicaron a mediados del siglo. El trabajo evidencia el distinto tratamiento de las voces en obras académicas y no académicas y confirma la periodización de los diccionarios académicos decimonónicos propuesta.
Estudio de la sexta edición del Diccionario de la lengua castellana de la Real Academia Española
Authors: Terrón Vinagre Natalia , Torruella Casañas Joan
Published: January 2020

La sexta edición del Diccionario de la lengua castellana de la Real Academia Española se publicó en 1822, solamente cinco años después de la inmediatamente anterior con la urgencia de resolver la falta en el mercado de ejemplares. La revisión del repertorio está marcada por un afán economizador tanto por lo que respecta a la supresión de lemas —como se indica en el Prólogo (1822), de aquellos que no se ajustan a las normas de pronunciación y ortografía o que han quedado anticuados— como al acortamiento de definiciones. En la revisión del enunciado definicional se mantienen los mismos criterios acordados para la edición precedente, lo que demuestra la continuidad entre ambas. El aumento, en cambio, es limitado y también presenta una línea continuadora de la edición anterior. Se trata, pues, de una edición más coherente desde el punto de vista de la técnica lexicográfica en la que se lleva a cabo una importante reflexión del tipo de léxico y de la información que debe incluirse en el diccionario.
Voces y acepciones nuevas en el DRAE 1837
Authors: Julià Luna Carolina
Published: January 2020

El objetivo principal de esta investigación es el examen de las características formales, semánticas, etimológicas y documentales de las voces y acepciones incorporadas en la octava edición del DRAE publicada en 1837. A partir del estudio lexicológico y documental de las adiciones se pretende dar cuenta de que, a pesar de ser una de las ediciones de la historia de la lexicografía académica menos destacadas del siglo XIX, el trabajo que refleja la selección de voces y definiciones añadidas es una muestra de la voluntad de mantener el compromiso que la Corporación tenía con el público al que llegaba la obra y también de la necesidad de mantenerla actualizada con el fin de que el diccionario reflejara la lengua de la época.
La décima edición del Diccionario de la lengua castellana de la Real Academia Española (1852): el aumento y la supresión de voces
Authors: Buenafuentes de la Mata Cristina
Published: January 2020

El objetivo principal de este trabajo es dar cuenta de la reconstrucción del modelo de “revisión y aumento” que se llevó a cabo en la décima edición del DRAE publicada en 1852. Para ello, esta investigación se centra en la macroestructura del DRAE 1852 a partir del análisis de las voces que constituyen su aumento y también de los vocablos que se suprimieron en esta edición. Asimismo este examen del aumento y la supresión de voces del DRAE 1852 se complementa con un contraste con las ediciones precedentes. Con ello, se pretende evidenciar la contribución del DRAE 1852 no solo en la construcción de la historia interna de la lexicografía académica sino también en la descripción del léxico del español del siglo XIX.
La recepción del léxico especializado en la novena (1843) y décima (1852) ediciones del DRAE
Authors: Muñoz Armijo Laura
Published: January 2020

En las ediciones centrales del siglo XIX surge una polémica intelectual con respecto a la admisión del léxico especializado. Los prólogos de la novena (1843) y décima (1852) ediciones dan cuenta de las tensiones en el seno de la Corporación por los ataques de los autores de la lexicografía no académica. El propósito de la presente investigación es caracterizar la admisión del léxico especializado en las dos ediciones de mediados del siglo XIX. Para ello, y en primer lugar, se partirá de la información sobre el léxico de especialidad que contienen los prólogos y las Reglas de 1838; en segundo lugar, se analizarán los lemas marcados y no marcados de ambas ediciones académicas. Finalmente, se tratará de determinar las posibles influencias que algunos diccionarios no académicos (principalmente las obras de Terreros (1786-1793), Núñez de Taboada (1825), Salvá (1846)) pudieron ejercer en la admisión de voces de especialidad en la novena y décima ediciones.
Modeling options for rainwater harvesting developments in a public institution as part of sustainable urban water management solutions
Authors: Csete Ákos Kristóf , Gulyás Ágnes
Published: January 2020

The water cycle of cities is very different from that of natural areas, and it is characterized by rtificial
energy flow processes and materials. Due to the high concentration of population, weather extremes in urban areas can cause greater personal and economic damage than in rural areas. Besides extreme amounts of precipitation, which is only one type of extreme weather events, it is important to be prepared for drought and dry periods (which are typical in Szeged and the southern region of the Great Hungarian Plain). During these periods, urban vegetation requires additional irrigation due to the urban artificial environment and the special species composition. This irrigation water basically means potable water resources. It is not a sustainable way to protect potable water resources, therefore any solution that can alleviate this situation is a major improvement. In our study, we modeled a rainwater harvesting system which is established in an elementary school in Szeged. We paid special attention to the quantitative and time distribution properties of the potential precipitation available for the rainwater harvesting system.
A Religião Cristã e a Evolução da Ciência: Considerações Históricas / Christianity Religion and the Evolution of Science: Historical Considerations
Authors: Melo Júlio de Fátimo Rodrigues de , Vieira Werner Bessa
Published: January 2020

A fé é parte integrante do homem, está com ele desde o nascimento, associada à fé sempre existe uma religião, que seria como um estado mítico, para muitos, uma forma de explicação ultrapassada. Enquanto que a ciência seria o motor do progresso e do conhecimento, conhecimento esse que transforma o mundo proporcionando melhor qualidade de vida aos seres humanos. A religião embora detentora de conhecimentos metafísicos, não deixa de fornecer repostas para grandes questões que afligem a humanidade, como por exemplo: por que existimos? De onde viemos? Para onde vamos? Há vida após a morte? Por que estamos aqui? Etc. Existe conflito entre ciência e religião? O fato de que no passado a Igreja Romana era detentora do conhecimento teológico e científico é inegável, pois determinava o céu, o inferno e também a rotação dos planetas.  O século XVIII trouxe consigo e ideia de que a religião estava associada ao engano devido a diversos escândalos do alto clero, ouve então o início de uma ruptura entre a ciência e a Igreja.   No século XIX desenvolveu-se uma apologética para fazer frente à disseminação do conhecimento científico através do método experimental, que postula que todo conhecimento válido começa da observação e da experiência. Questões metafísicas não tinham lugar nesse tipo de conhecimento, no entanto, a religião nunca deixou de fornecer respostas que envolvem esse tipo de questões. Sabendo que cada uma dessas vertentes fala de coisas diferentes, é possível estabelecer conflito entre elas? Ou elas não têm como competir? É inegável que cada uma a sua maneira, religião e ciência têm oferecido recursos valiosos para uma mudança de consciência ética e de ação entre os seres humanos. Três pontos serão abordados nesse artigo, primeiro, como estava organizado o conhecimento científico antes do cristianismo, segundo a situação do conhecimento científico após o surgimento do cristianismo e terceiro, após a ruptura da ciência com a Igreja e faremos também uma análise acerca dessa ruptura, considerando se foi ou não benéfica.
Achalasia Revealed by Respiratory Failure and Hemodynamic Instability
Authors: Blaney Hanna , Agrawal Nitin , Ashfaq Samir , Naumann Christopher
Published: January 2020

Achalasia is a rare condition that most often presents with progressive dysphagia to solids and liquids. We report a case of achalasia presenting with acute respiratory failure and hemodynamic instability requiring both ventilator and vasopressor support because of extrinsic compression of the airway and left atrium by a dilated and fluid-filled esophagus. This is the first case reported of achalasia, causing both left atrial compression and airway compression.
Pancreatic Adenocarcinoma With Synchronous Colonic Metastases
Authors: Yewale Rohan , Ramakrishna Banumathi , Vijaykumar Kavita , Balasundaram Partheeban , Arulprakash S. , Radhakrishna Patta , Ramakrishna B.S.
Published: January 2020

Metastases from pancreatic malignancy are commonly known to occur in the regional lymph nodes, liver, lung, and peritoneum. Synchronous or metachronous metastasis from the pancreas to the colon is rare, with only 6 cases reported in the literature. We report a man who was found to have adenocarcinoma on biopsies from synchronous lesions in the colon and the pancreas. The immunohistochemistry report revealed the diagnosis of a primary pancreatic malignancy with synchronous colonic metastases.
In ovo Feeding of Butyric Acid Replacing Antibiotics Function to Increase Poultry Productivity
Authors: Krisnan Rantan , Retnani Yuli , Tangendjaja Budi , Mutia Rita , Jayanegara Anuraga
Published: January 2020

Antibiotics have an important role in increasing livestock productivity. The ban on the use of these products encourages efforts to find substitute products. Butyric acid is one of the organic acids and considered to be potential to replace the role of antibiotics. In principle, both antibiotics and butyric acids can create livestock conditions physiologically and metabolically well to achieve good productivity. Several mechanisms of butyric acid in increasing livestock productivity can provide explanation for the positive effects of this material. Characteristics of butyric acids such as corrosive, volatile and have unpleasant odor encourage the need for an appropriate application technology. In ovo feeding technology can be the right solution to eliminate the constraints of using butyric acid. This technology has also been widely studied and proven to increase livestock productivity through improved hatching parameters, performance of livestock, improvement of organs/digestive tract (intestine), repair of bones, muscles and meat, and enhancement of immunity.
Melanocortin-4 Receptor (MC4R) Gene as the Main Gene for Rapid Growth Selection in Beef Cattle
Authors: Prihandini Peni Wahyu , Maharani D
Published: January 2020

Genetic improvement for economic traits such as growth is important in beef cattle selection program. This paper discusses melanocortin-4 receptor (MC4R) gene as a candidate gene for rapid growth based on its function, location and pathway, as well as its polymorphism and identified genotypes associated with economic traits, and its application as a marker-assisted selection. MC4R is a prominent gene encoding growth traits and has a critical role in mediating the effect of leptin in regulating food consumption and energy balance. Many identified MC4R gene polymorphisms are associated with growth traits. The MC4R gene, therefore, is considered as a functional candidate gene for growth traits and can be used as a marker in selection program based on molecular genetics. The use of molecular markers such as MC4R gene, therefore, can be applied in genetic improvement program for growth traits in cattle. By using MC4R gene, the efforts to build breeding system in small populations can be proposed. For instance, with an effective population size (Ne) of about 40 heads, the first generation (G1) will be obtained with a composition of GG 61.1%, CG 33.3% and CC 5.6% and male and female ratio of 178:11 and generates ideal Ne of 41 heads. In the third generation, therefore, GG composition will be 100%. The results of molecular analysis can be further used as a guideline in the development and genetic improvement strategies of beef cattle.
O direito à educação de jovens em cumprimento de medidas socioeducativas: uma reflexão a partir dos planos estaduais de educação no Brasil
Authors: Souza Livia Silva de , Lacé Andréia Mello , Nascimento Daniela Gomes do
Published: January 2020

O presente artigo tem por objetivo descrever e identificar como a política educacional destinada aos jovens em cumprimento de medidas socioeducativas está consignada nas metas e estratégias do Plano Nacional de Educação e dos Planos Estaduais de Educação das 27 unidades federativas. A pesquisa exploratória apoiada em fontes primárias possuiu uma abordagem qualitativa e revelou, entre outros aspectos, que a socioeducação aparece em algumas estratégias vinculada ao sistema prisional e a jovens em situação de rua. Analisamos, tal como assevera Flores (2008) e Sposito (2009), que a positivação do direito à educação para jovens em cumprimento de medida socioeducativa é um avanço, mas existem fragilidades no que tange ao planejamento e à execução de políticas de escolarização.
Organização do ensino na EJA para os alunos com deficiência intelectual
Authors: CAMPOS JULIANE APARECIDA DE PAULA PEREZ CAMPOS , Tassinari Ana Maria , Galvani Marcia Duarte
Published: January 2020

A pesquisa objetivou descrever a organização do ensino da Educação de Jovens e Adultos (EJA) para os alunos com deficiência intelectual matriculados nessa modalidade. Foram participantes quatro professores da sala comum da Educação de Jovens e Adultos (EJA) de dois municípios do interior paulista, foram realizadas entrevistas e observação em sala de aula. Os resultados evidenciaram a necessidade de a Secretaria Municipal de Educação, dos municípios estudados, investir na formação continuada dos professores atuantes nessa modalidade, tendo como base o apoio da Educação Especial e adaptações curriculares.
A política escolar na França na atualidade (2017-2019): tentativas de interpretação
Authors: Robert André D. , Ulhôa Leonardo Moreira , Khoury Zeina Abdulmassih
Published: January 2020

Este artigo tenta analisar os dois anos (2017-2019) da política escolar conduzida na França pelo ministro Jean-Michel Blanquer no governo do novo presidente Emmanuel Macron. Esta política é de fato particularmente difícil de descriptografar, na medida em que não pretende ser nem de direita, nem de esquerda. O autor analisa primeiro o quadro ideológico e teórico dessa política (no centro do qual, encontra-se o neoliberalismo e a neurociências), em seguida, alguns aspectos da comunicação e da ação do ministro que busca muitos efeitos midiáticos, enfim os principais significados da lei conhecida como "escola de confiança", promulgada em julho de 2019. Essa análise mostra que por trás das boas intenções declaradas de luta contra o fracasso escolar, se esconde uma política autoritária caracterizada por uma desconfiança em torno de professores e orientações desiguais, reforçando a seleção em detrimento dos alunos com maior dificuldade.
Regulations on Access to Government Information and Impacts on Open Government: The Case of Turkey
Authors: EROĞLU Şahika
Published: January 2020

The fundamental elements of open government, i.e. openness, participation, and collaboration, can be secured through well-structured regulations governing access to information. Therefore, existing access to information regulations, which are based upon the pre-open government era, should be structured or updated under the mandates of open government. The present study assumes the perspective of the relevant literature to consider the effectiveness of regulations governing access to information in public’s access to information, their relationships with the government, and the effects of open government on regulations governing access to information. With its starting point in the literature, the study assesses the scope of the existing Law on the Right to Information in Turkey, as a country preparing for an open government in line with specific criteria, and defines the effects of this Law on the preparations for an open government, as well as its current/potential shortcomings. Using document analysis as its research methodology, this study reveals that the Law on the Right to Information in Turkey does not sufficiently cover the requirements of open government. The research conclusions are presented along with recommendations for the updated structuring of the Law on the Right to Information.
Astragalus polysaccharides protects thapsigargin-induced endoplasmic reticulum stress in HT29 cells
Authors: Zheng Lie , Zhang Ya-Li , Chen Xuan , Chen De-Liang , Dai Yan-Cheng , Tang Zhi-Peng
Published: January 2020

Aim

This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway.

Methods

HT29 cells were induced by thapsigargin for 12 hours, then treated with APS for 24 hours, and the gene expressions of GRP78, CHOP and eIF2a were quantified by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The expression of GRP78, CHOP, PERK, p-PERK, eIF2a, and p-eIF2a were detected by Western blot.

Results

The ER stress caused by thapsigargin strongly up-regulated the expression of GRP78 and CHOP in HT29 cells, which activated the PERK-eIF2a pathway. There was an increase in PERK phosphorylation, and induction of eIF2a in HT29 cells. Thapsigargin caused significant ER expansion in HT29 cells due to the 12-hour ER stress. Importantly, Astragalus polysaccharide significantly inhibited the phosphorylation of PERK and eIF2a, which reduced the mRNA levels of GRP78, CHOP, PERK and eIF2a, and inhibited the ER expansion in HT29 cells after 24 hours of treatment.

Conclusion

The results indicate that APS reduces the expression of GRP78 and CHOP in HT29 cells, at least in part, by preventing the activation of the PERK-eIF2a signaling pathway.
Abnormal asexual reproduction of thalli of Ecklonia stolonifera (Laminariales, Phaeophyceae) off the coast of Nakanoshima in the Oki Islands, Japan
Authors: Hayashi Yuichi , Notoya Masahiro , Yotsukura Norishige
Published: January 2020

Multiple abnormal individuals of Ecklonia stolonifera with thalli that developed numerous shoot-like structures on the lateral blades were found in two littoral regions of Nakanoshima in the Oki Islands, Shimane Prefecture, Japan. Except for the presence of these diagnostic structures, no other morphological differences were observed between the abnormal and normal individuals. The development of the shoot-like structures isolated from the lateral blade was the same as that of typical vegetative reproductive sporophytes that formed on stolons. In the abnormal individuals, when cultivation was performed using zoospores, the shoot-like structures were observed on the progeny after 18 months of culture and 20.0% of individuals exhibited these structures.
Atrial fibrillation: is there a role for cardiac troponin?
Authors: Sepehri Shamloo Alireza , Arya Arash , Darma Angeliki , Nedios Sotirios , Döring Michael , Bollmann Andreas , Dagres Nikolaos , Hindricks Gerhard
Published: January 2020

Atrial fibrillation (AF) is the most common sustained arrhythmia, and its prevalence rate is expected to be doubled over the next decades. Despite the wide use of biomarkers in the management of different cardiac diseases such as myocardial infarction and heart failure, utilization of biomarkers in AF management is not routinely recommended by current guidelines. There is also growing evidence that higher levels of cardiac-specific troponin, as an intracellular protein involved in cardiomyocyte contraction, may be associated with the risk of incident and recurrent AF and its complications. In the present paper, we review the association between troponin and AF and propose clinical suggestions for use of troponin in the management of AF patients.
Characterization of substrate specificity and novel autoprocessing mechanism of dipeptidase A from Prevotella intermedia
Authors: Sarwar Mohammad Tanvir , Ohara-Nemoto Yuko , Kobayakawa Takeshi , Naito Mariko , Nemoto Takayuki K.
Published: January 2020

Prevotella intermedia, a Gram-negative anaerobic rod, is frequently observed in subgingival polymicrobial biofilms from adults with chronic periodontitis. Peptidases in periodontopathic bacteria are considered to function as etiological reagents. Prevotella intermedia OMA14 cells abundantly express an unidentified cysteine peptidase specific for Arg-4-methycoumaryl-7-amide (MCA). BAU17746 (locus tag, PIOMA14_I_1238) and BAU18827 (locus tag, PIOMA14_II_0322) emerged as candidates of this peptidase from the substrate specificity and sequence similarity with C69-family Streptococcus gordonii Arg-aminopeptidase. The recombinant form of the former solely exhibited hydrolyzing activity toward Arg-MCA, and BAU17746 possesses a 26.6% amino acid identity with the C69-family Lactobacillus helveticus dipeptidase A. It was found that BAU17746 as well as L. helveticus dipeptidase A was a P1-position Arg-specific dipeptidase A, although the L. helveticus entity, a representative of the C69 family, had been reported to be specific for Leu and Phe. The full-length form of BAU17746 was intramolecularly processed to a mature form carrying the N-terminus of Cys15. In conclusion, the marked Arg-MCA-hydrolyzing activity in Pre. intermedia was mediated by BAU17746 belonging to the C69-family dipeptidase A, in which the mature form carries an essential cysteine at the N-terminus.
Human papillomavirus oncoproteins and post-translational modifications: generating multifunctional hubs for overriding cellular homeostasis
Authors: Basukala Om , Sarabia-Vega Vanessa , Banks Lawrence
Published: January 2020

Human papillomaviruses (HPVs) are major human carcinogens, causing around 5% of all human cancers, with cervical cancer being the most important. These tumors are all driven by the two HPV oncoproteins E6 and E7. Whilst their mechanisms of action are becoming increasingly clear through their abilities to target essential cellular tumor suppressor and growth control pathways, the roles that post-translational modifications (PTMs) of E6 and E7 play in the regulation of these activities remain unclear. Here, we discuss the direct consequences of some of the most common PTMs of E6 and E7, and how this impacts upon the multi-functionality of these viral proteins, and thereby contribute to the viral life cycle and to the induction of malignancy. Furthermore, it is becoming increasingly clear that these modifications, may, in some cases, offer novel routes for therapeutic intervention in HPV-induced disease.
Performance Enhancement of Encoding–Decoding Multidiagonal and Walsh Hadamard Codes for Spectral Amplitude Coding-Optical Code Division Multiple Access (SAC-OCDMA) Utilizing Dispersion Compensated Fiber
Authors: Majeed Majidah H. , Ahmed Riyadh Khlf
Published: January 2020

Spectral Amplitude Coding-Optical Codes Division Multiple Access (SAC-OCDMA) is a future multiplexing technique that witnessed a dramatic attraction for eliminating the problems of the internet in optical network field such as multiple-user access and speed’s growth of the files or data traffic. In this research article, the performance of SAC-OCDMA system based on two encoding–decoding multidiagonal (MD) and Walsh Hadamard (WH) codes is enhanced utilizing three different schemes of dispersion compensating fiber (DCF): pre-, post- and symmetrical compensation. The system is simulated using Optisystem version 7.0 and Optigrating version 4.2. The performance of the proposed system is specified in terms of bit error rate (BER), Q-factor and eye diagram. It has been observed that the compensated system based on MD code is performs much better compared to the system based on WH code. On the other hand, the compensated SAC-OCDMA system with symmetrical DCF has the lowest values of BER and largest values of Q-factor, so it is considered the best simulated scheme contrasted with pre- and post-DCF.
Evaluation of ocean circulation models in the computation of the mean dynamic topography for geodetic applications. Case study in the Greek seas
Authors: Mintourakis I. , Panou G. , Paradissis D.
Published: January 2020

Precise knowledge of the oceanic Mean Dynamic Topography (MDT) is crucial for a number of geodetic applications, such as vertical datum unification and marine geoid modelling. The lack of gravity surveys over many regions of the Greek seas and the incapacity of the space borne gradiometry/gravity missions to resolve the small and medium wavelengths of the geoid led to the investigation of the oceanographic approach for computing the MDT. We compute two new regional MDT surfaces after averaging, for given epochs, the periodic gridded solutions of the Dynamic Ocean Topography (DOT) provided by two ocean circulation models. These newly developed regional MDT surfaces are compared to three state-of-theart models, which represent the oceanographic, the geodetic and the mixed oceanographic/geodetic approaches in the implementation of the MDT, respectively. Based on these comparisons, we discuss the differences between the three approaches for the case study area and we present some valuable findings regarding the computation of the regional MDT. Furthermore, in order to have an estimate of the precision of the oceanographic approach, we apply extensive evaluation tests on the ability of the two regional ocean circulation models to track the sea level variations by comparing their solutions to tide gauge records and satellite altimetry Sea Level Anomalies (SLA) data. The overall findings support the claim that, for the computation of the MDT surface due to the lack of geodetic data and to limitations of the Global Geopotential Models (GGMs) in the case study area, the oceanographic approach is preferable over the geodetic or the mixed oceano-graphic/geodetic approaches.
The structure and composition of solid complexes comprising of Nd(III), Ca(II) and D-gluconate isolated from solutions relevant to radioactive waste disposal
Authors: Böszörményi Éva , Lado Jorge , Dudás Csilla , Kutus Bence , Szabados Márton , Varga Gábor , Pálinkó István , Sipos Pál
Published: January 2020

Certain complexing agents (such as D-gluconate, D-isosaccharinate, etc.) as well as actinides and lanthanides are simultaneously present in cementitious radioactive waste repositories and (in the presence of water) are capable of forming complex compounds. Such processes may immobilize radionuclides and are of importance in the thermodynamic modelling of the aqueous chemistry of waste repositories. Nd(III) is considered to be a suitable model for trivalent lanthanides and actinides, due to the similarity of their ionic radii. In the current work, solid complexes isolated from aqueous solution containing Nd(III), Ca(II) and D-gluconate (Gluc−) were investigated. In an aqueous solution containing Nd(III) and Gluc−, the formation of a precipitate was observed at pH ≥ 8. This precipitate was found to redissolve around pH ~ 11, but reprecipitated when Ca(II) ions were added to the solution. In order to gain an insight in binary and ternary aqueous systems, in the present work we report the structure of these solid complexes obtained from XRD, FT-IR, Raman, SEM-EDAX and UV-DRS measurements. The structure of these solids, where possible, was compared with those identified in solution. The compositions of these complexes are suggested to be NdGlucH−1(OH) · 2H2O and CaNdGlucH−1(OH)3 · 2H2O, respectively. In these, the chemical environment of the Nd(III) was found to be the same as that in the NdGlucH−1(OH)0(aq) solution species.
Penetrating abdominal injuries in an emerging semiurban teaching hospital
Authors: Olaogun Julius Gbenga , Etonyeaku Amarachukwu Chiduziem , Ige Joshua Taye , Wuraola Obafemi Kayode
Published: January 2020

Objective: There has been a worldwide rise in the prevalence of penetrating abdominal injury (PAI), and there are both inter-country and intra-country variations in frequencies. This study evaluates the mechanisms and pattern of penetrating abdominal injuries and the treatment outcome in our center. Methods: This descriptive study of adult patients managed for PAI was conducted at the Ekiti State University Teaching Hospital (EKSUTH), Ado-Ekiti from January 2015 to December 2018. Data were prospectively collected and analyzed by using descriptive statistics from Statistical Package for Social Sciences (SPSS) version 20.0. Results: There were 96 patients managed for abdominal injuries during the study period. Forty-six (47.9%) of them had PAI, while 50 (52.1%) others sustained blunt trauma. Patients ages ranged from 17-72 years (mean = 34.2±10.8 years; median = 34 years). Majority, 42 (91.3%), were males, while 4 (8.7%) were females (M: F=11:1). The most afflicted age group was in the 4th decade. Majority of the injuries were due to gunshot (60.9%) followed by stab (26.1%), unsafe abortion (6.5%), road traffic injury (4.3%) and fall (2.2%). Gastrointestinal injuries were the most common with small bowel perforations predominating. Solid organ injuries were only seen in 3 (7.9%) patients. Eight (17.4%) had associated extra-abdominal injuries. Thirty-eight (82.6%) patients required exploratory laparotomy, while 8 (17.4%) were managed non-operatively. The negative laparotomy rate was 2.6%. Seven (15.2%) patients developed complications which were mostly wound infection (10.8%). The duration of hospital stay was 1-58 days (mean 12.7±10.5). Three patients (6.5%) with gunshot injuries died. Conclusion: Gunshot wounds were the major variant of PAI, and the highest cause of mortality from it. Gut injuries were most common, and exploratory laparotomy remains the main-stay of treatment, while non-operative management is practicable in carefully selected cases.
Progression of Combat Sport Activities for Youth Athletes
Authors: Morales Jose , Fukuda David H. , Curto Cristina , Iteya Misaki , Kubota Hiroshi , Pierantozzi Emanuela , La Monica Michael
Published: January 2020

Combat sport activities can play a role in the development of children and adolescents, and they are often a part of physical education classes and extracurricular activities. In addition to the psychological and social benefits these activities offer, they are also highly beneficial in physiological terms, as they are based on intermittent, metabolically demanding activities that help participants improve their physical fitness. The aim of this work is to propose a logical progression of game-based activities that reproduce different technical-tactical and physiological requirements of combat sports. The 5 phases become progressively more difficult with respect to both strategy and intensity.
Variability in Particle Size Distribution Due to Sampling
Authors: Dubé Jean-Sébastien , Ternisien Julie , Boudreault Jean-Philippe , Duhaime François , Éthier Yannic
Published: January 2020

Sampling particulate matter for particle size distribution (PSD) analysis is a task routinely performed in geotechnical and geoenvironmental engineering. Pitard (2019) mentions that “for a sample to be representative of anything, the first rule to fulfill is to ensure that the sample is representative of all the particle size fractions.” Several sampling techniques exist for obtaining samples of particulate matter from a lot, but their representativeness has rarely been documented, either experimentally or theoretically. To this end, this article studied the representativeness of four sampling techniques applied to moist and dry particulate matter, namely riffle splitting, fractional shoveling, 2-dimensional incremental sampling (2-DIS), and grab sampling. Bias being small because of experimental design, relative variance was used to assess sampling performance. Except for the largest size fraction (>9.5 mm), for which all sampling techniques gave poor results because of insufficient sample mass, riffle splitting was the most reproducible technique (CV = 6.47 %) and showed the smallest increase in variability compared to the fundamental relative sampling variance (i.e., a CV increase of 0.66 %), followed by fractional shoveling (7.68 %, 2.59 %), grab sampling (11.7 %, 6.51 %), and 2-DIS (16.3 %, 11.1 %). For fractional shoveling, sampling dry matter (CV = 19.2 %) significantly increased sampling variability compared to moist matter by 11.5 %. Furthermore, theoretical estimation of minimum sample mass requirements showed that mass requirements in ASTM D6913/D6913M-17, Standard Test Methods for Particle-Size Distribution (Gradation) of Soils Using Sieve Analysis, can lead to larger sampling variance than expected. Guidelines for specimen procurement ASTM D6913/D6913M-17 were also analyzed and judged insufficient with respect to fundamental sampling principles.
An Experimental Study of the Effects of Different Reinforcement Ratios on the Impact Resistance Behaviors of Reinforced Concrete Beams
Authors: Zhou Xiwu , Wang Xiangyu , Zhang Runcheng , Zhang Guoxue , Xiong Ruisheng
Published: January 2020

In this experimental study, for the purpose of furthering the understanding of the effects of different reinforcement ratios on the impact resistance behaviors of reinforced concrete (RC) beams, a series of vertical impact tests were conducted on five RC beams with different reinforcement ratios using a domestically advanced ultrahigh heavy drop hammer impact testing machine system. The impact velocities and force of the drop hammer during the impacts, displacements, and strain of the test points, as well as the crack propagation process, were collected and analyzed. The experimental test results revealed the following. (1) When the reinforcement ratios ranged between 0.58 and 1.63 %, the RC beams had mainly suffered bending failures. However, when the reinforcement ratios were increased, it was observed that the overall stiffness of the beams had been effectively improved; displacements, steel strain, and damages were reduced; and the impact resistance abilities of the beams had been enhanced. (2) When the reinforcement ratios had ranged from 1.63 to 2.57 %, shear failures were found to be the main failure mode of the RC beams. It was found that increases in the reinforcement ratios could not effectively reduce the damages and were not conducive to the beams’ resistance to impact loads. (3) It was determined that because of the shearing effects of the impact loads, the shear force of the RC beams had increased.
Ruína e materialidade: Uma arqueologia visual acerca da transformação de antigos espaços do Museu de Arqueologia de Xingó
Authors: Pereira Santos da Silva Marcus Vinícius
Published: January 2020

O ensaio visual a seguir preconiza à escavação imagética de antigos espaços do Museu de Arqueologia de Xingó (MAX-UFS) que, em decorrência de seu abandono, transformaram-se, ao longo do tempo, em ambientes de ruína. A argumentação apresentada aqui busca não apenas legar uma maior importância à decadência como um fenômeno de transformação espacial, mas como a materialidade manifestada em uma ruína moderna contribui para a formação do valor histórico e arqueológico desta. Neste trabalho a fotografia é encarada enquanto testemunha do encontro ocorrido entre o arqueólogo e a cultura material, traduzindo a maneira pela qual ele escolhe representa-lo e, consequentemente, como esta escolha influencia na interpretação arqueológica produzida por intermédio de uma documentação visual.
Abstract: The following visual essay describes an imaging excavation of old spaces at the Museu de Arqueologia de Xingó that, due to their abandonment over time, are now in ruins. The argument presented here seeks not only to attach greater importance to decadence as a phenomenon of spatial transformation, but also how the materiality manifested in modern ruins contributes to the formation of their historical and archaeological value. In this work, photography bears witness to the encounter between archaeologist and material culture, translating how it is represented and how this influences the archaeological interpretation produced through a visual document.
Efluente da parboilização de arroz como cosubstrato em biodigestão anaeróbia de efluente de laticínios
Authors: Nadaleti Willian Cézar , Lourenço Vitor Alves , Schoeler Guilherme Pereira , Leandro Diuliana , Quadro Maurízio Silveira
Published: January 2020

O Brasil é o um dos maiores produtores de laticínios do mundo, o setor gera de 2,5 e 4,0 m³ de efluente com alta concentração de gorduras para cada metro cúbico de leite processado. O emprego de um cosubstrato na biodiegstão anaeróbia é capaz de promover a diluição de compostos inibitórios e, assim, elevar a produção de biogás. O efluente da indústria de arroz parboilizado é um possível cosubstrato para a biodigestão do efluente de laticínios, visto que não apresenta compostos inibitórios e é gerado em larga escala no país. O objetivo do estudo foi avaliar o uso desse efluente como cosubstrato para o processo de biodigestão anaeróbia do efluente da produção de laticínios, ambos gerados no município de Pelotas-RS. Os biodigestores operaram à 35 °C em batelada, sendo que ao fim de 276 horas, a produção de biogás foi diretamente proporcional ao teor de cosubstrato na mistura, onde a maior proporção de efluente da parboilização de arroz produziu o maior volume de biogás, 3,39E-03 m³, e a biodigestão apenas do efluente da indústria de laticínios produziu 1,21E-03 m³, evidenciando que o efluente da parboilização de arroz apresenta resultados satisfatórios quando empregado como cosubstrato para a biodigestão anaeróbia do efluente da produção de laticínios.
Uma proposta de matriz de avaliação de jogos digitais para o ensino-aprendizagem-uso de língua adicional
Authors: Finardi Kyria Rebeca , Vergine Vieira Gicele , Gomes Leão Roberta
Published: January 2020

Este estudo partiu do pressuposto de que a incorporação de tecnologias na educação tem que ser associada a práticas pedagógicas que efetivamente favoreçam o aprendizado para propor uma matriz de avaliação de jogos para o ensino-aprendizado-uso de L. Onze parâmetros foram propostos e testados por meio de um levantamento de jogos digitais disponíveis online. O estudo foi conduzido em duas etapas: a primeira preocupou-se com a proposição da matriz e a segunda com a testagem dos parâmetros propostos por ela. Os resultados do estudo sugerem que a matriz proposta representa um auxílio relevante para professores, aprendizes e usuários de L2 uma vez que reflete pressupostos importantes que subjazem a aquisição e o uso de uma L2, bem como fornece subsídios para seleção de aplicativos que atendam aos objetivos educacionais almejados.
Elementos de gamificação presentes em Livros Literários Infantis digitais interativos em formato de Aplicativo (LLIA): análise de práticas multiletradas na formação de leitores
Authors: Machado Paulo Henrique , Remenche Maria de Lourdes Rossi
Published: January 2020

O presente estudo tem como objetivo analisar as práticas multiletradas mobilizadas pelos elementos de gamificação presentes em Livros Literários Infantis digitais interativos em formato de Aplicativos (LLIA) que contribuem para a formação do leitor literário na infância. Para tanto, delimitou-se como corpus de pesquisa LLIA finalistas do BolognaRagazzi Digital Award (Itália) no ano de 2016 e do Prêmio Jabuti (Brasil) na categoria “Infantil Digital” nos anos de 2015, 2016 e 2017. Trata-se de pesquisa qualitativo-interpretativista, cujo arcabouço teórico-metodológico ancora-se nos estudos dos multiletramentos, da literatura infantil digital, da gamificação, entre outros. Identificou-se que na relação entre as narrativas dos LLIA e os elementos de gamificação, estes contribuem para deixar os enredos mais emocionantes, pois os roteiros das histórias contemplam níveis progressivos, desafios, missões, busca por recompensas e retroalimentações, que possibilitam maior integração dos conteúdos com o imaginário do leitor, oportunizando que este imponha o seu ritmo de leitura.
Single-Cell Molecular and Cellular Architecture of the Mouse Neurohypophysis
Authors: Chen Qiyu , Leshkowitz Dena , Blechman Janna , Levkowitz Gil
Published: January 2020

The neurohypophysis (NH), located at the posterior lobe of the pituitary, is a major neuroendocrine tissue, which mediates osmotic balance, blood pressure, reproduction, and lactation by means of releasing the neurohormones oxytocin (OXT) and arginine-vasopressin (AVP) from the brain into the peripheral blood circulation. The major cellular components of the NH are hypothalamic axonal termini, fenestrated endothelia and pituicytes, the resident astroglia. However, despite the physiological importance of the NH, the exact molecular signature defining neurohypophyseal cell types and in particular the pituicytes, remains unclear. Using single-cell RNA sequencing (scRNA-Seq), we captured seven distinct cell types in the NH and intermediate lobe (IL) of adult male mouse. We revealed novel pituicyte markers showing higher specificity than previously reported. Bioinformatics analysis demonstrated that pituicyte is an astrocytic cell type whose transcriptome resembles that of tanycyte. Single moleculein situhybridization revealed spatial organization of the major cell types implying intercellular communications. We present a comprehensive molecular and cellular characterization of neurohypophyseal cell types serving as a valuable resource for further functional research.