bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penggunaan Media Sosial Instagram Terhadap Keputusan Pembelian Kaum Millenial Di Restoran Gokana Ramen & Teppan Mall Ratu Indah Makassar
Authors: Hany  , Daniel Lallo Pakiding  , Uli Urbanus Bubun  , Westerini Lusdani
Published: April 2024

Social media is an internet platform where it is possible for individuals to share directly and communicate continuously with their community. The use of social media has become part of the experience of growing up for teenagers to seek entertainment and the latest information. The purpose of this study is to analyze and examine the effect of using Instagram social media on millennial purchasing decisions at Gokana Ramen Restaurant & Teppan Mall Ratu Indah Makassar. The data collection technique was carried out with a quantitative approach with a sample size of 100 respondents. The data analysis method in this study used descriptive data analysis, simple linear regression analysis and hypothesis testing. The results of this study indicate that the use of Instagram social media has a significant and positive effect on millennial purchasing decisions at Gokana Ramen Restaurant & Teppan Mall Ratu Indah Makassar.
ANALISIS RASIO LIKUIDITAS PADA KOPERASI PEGAWAI NEGERI (KPN) AO’ GADING PGRI RANTING BALUSU KABUPATEN TORAJA UTARA
Authors: Tallulembang Pabita
Published: April 2024

Metode analisis yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa berdasrkan hasil perhitungan current ration pada tahun 2018 sebesar 3,51%, pada tahun 2019 sebesar 3,41%, dan tahun 2020 sebesar 3,31%. Sedangkan hasil perhitungan cash ratio pada tahun 2018 sebesar 0,71 %, tahun 2019 sebesar 1,04% dan tahun 2020 sebesar 1,20%. Berdasarkan hasil perhitungan current ratio pada KPN Ao’ Gading PGRI Ranting Balusu Kabupaten Toraja Utara dikategorikan tidak baik menurut peraturan menteri negara Koperasi dan UKM Republik Indonesia, Nomor 06/M/KUKM/2006 Tanggal 1 Mei 2006 dan hasil perhitungan cash ratio pada KPN Ao’ Gading PGRI Ranting Balusu Kabupaten Toraja Utara dikategorikan tidak baik menurut peraturan menteri negara koperasi dan UKM Republik Indonesia, Nomor 06/M/KUKM/2006. Berdasarkan analisis yang dilakukan dengan beberapa rumus rasio likuiditas menunjukkan bahwa likuiditas Koperasi Pegawai Negeri (KPN) Ao’ Gading PGRI Ranting Balusu dikategorikan tidak baik menurut standar penilaian peraturan menteri koperasi dan UKM RI, Nomor 06/M/KUKM/2006 bukan berarti tidak likuid tetapi koperasi tersebut tidak mengoptimalkan aset lancarnya dikarenakan kasnya masih terlalu kecil dibandingkan piutangnya meskipun aset lancarnya lebih besar dari utang lancarnya.
STRATEGI PENJUALAN BAHAN BAKAR MINYAK (BBM) PADA PERTAMINI YOGA DI KECAMATAN RANTEPAO KABUPATEN TORAJA UTARA
Authors: Randa Windi
Published: April 2024

Penelitian ini bertujuan untuk mengetahui Strategi Penjualan Bahan Bakar Minyak (BBM) pada Pertamini Yoga di Kecamatan Rantepao, Kabupaten Toraja utara. Rumusan Masalah pada penelitian ini adalah Strategi Penjualan Bahan Bakar Minyak (BBM) pada Pertamini Yoga di Kecamatan Rantepao, Kabupaten Toraja Utara. Persoalan penelitian ini adalah bagaimana Strategi Penjualan Bahan Bakar Minyak (BBM) pada Pertamini Yoga di Kecamatan Rantepao, Kabupaten Toraja Utara. Penelitian ini menggunakan penelitian Deskriptif Kualitatif dengan teknik pengumpulan data  yaitu secara observasi dan wawancara. Populasi yang digunakan adalah para konsumen yang datang mengisi bahan bakar di Pertamini Yoga serta pemilik Pertamini Yoga. Strategi penjualan  yang digunakan dalam penelitian ini yaitu terdapat 4 strategi diantaranya: strategi produk, strategi harga, strategi pelayanan dan strategi tempat. Hasil penelitian menyatakan bahwa minat masyarakat terhadap pertamini Yoga dipengaruhi oleh kwalitas produk, penentuan harga, pelayanan yang baik serta kemudahan aksesnya.
Index Kepuasan Pengguna Layanan terhadap Pelayanan pada Kantor SAMSAT Makale, Kabupaten Tana Toraja
Authors: Limbongan Mey Enggane , Oktajayanice Wildalend
Published: April 2024

This study aims to determine the service user satisfaction index towards services at the Makale SAMSAT office, Tana Toraja Regency. The research method uses quantitative descriptive analysis with the calculation of the Community Satisfaction Survey (SKM) at PERMENPAN RB Number 14 of 2017. The data collection techniques were carried out using observation, questionnaires and documentation techniques. The results of the study were based on the calculation of the Community Satisfaction Survey of the 9 elements that had the highest IKM value, namely facilities and infrastructure with an SKM value of 8.4 and an IKM conversion value of 85 in good category. While the element that has the lowest IKM value is the element of service costs/tariffs getting an SKM value of 2.773 and the IKM conversion value of 69.325 is in the poor category. Overall, the IKM value at the Makale SAMSAT Office service unit is 3.093 with an IKM conversion value of 77.85 which means the service quality at the Makale SAMSAT Office, Tana Toraja Regency is at the 'B' or "Good" level.
Pengaruh Human Capital Dan Kepuasan Kerja Terhadap Kinerja Karyawan Di Universitas Matana
Authors: Yangid Fanggidae Paulus
Published: April 2024

In this study an analysis of primary data was collected using a questionnaire with the sample being all academic and non-academic employees at Matana University. The data were processed using statistical methods using SPSS and calculations using numerical methods. The relationship and its influence uses the multiple regression method where Human Capital and Job Satisfaction as independent variables have a significant and positive influence on performance, amounting to 51.65% and the remaining 48.35% is influenced by other variables, Human Capital and Kingdom Satisfaction have a strong correlation to Performance which is equal to 0.7295.
Estudio epidemiológico prospectivo de lesiones cutáneas en recién nacidos en el Hospital L. C. Lagomaggiore, Mendoza
Authors: Arzalluz Gabriela Delia , Coletto Gianina Anabella , Scocchi Julieta , Chessé Carla , Marabini Noelia Carla
Published: April 2024

Antecedentes: la piel del recién nacido tiene características funcionales y estructurales diferentes a la del adulto. Posee un rol importante en la regulación de la temperatura y el equilibrio hídrico, y funciona como una barrera contra las infecciones. Las lesiones cutáneas en neonatos son frecuentes y variadas.
Objetivos: determinar la prevalencia de lesiones cutáneas de los recién nacidos en el Hospital L. C. Lagomaggiore de Mendoza, Argentina; establecer factores que influyen en la aparición de las lesiones; correlacionar los resultados con la bibliografía.
Diseño: estudio epidemiológico descriptivo, prospectivo, observacional y transversal.
Materiales y métodos: se evaluaron 160 recién nacidos sanos dentro de los 30 días de vida. Se incluyeron aquellos que se encontraban en sala de internación conjunta del primer piso de la Maternidad, las interconsultas realizadas en el Servicio de Dermatología y pacientes del consultorio de seguimiento de Dermatología Neonatal del Hospital L. C. Lagomaggiore, desde febrero hasta agosto de 2023.
Resultados: se registró un total de 160 pacientes. El 52% pertenecía al sexo femenino y el 48% al masculino. Del total de recién nacidos (n=160), el 95,63% (n=153) presentó alguna lesión cutánea. Las cinco entidades más prevalentes fueron: mancha mongólica (40,52%; n=62), hiperplasia sebácea (36,6%; n=56), malformación vascular transitoria (33,9%; n=52), eritema tóxico neonatal (30,7%; n=47) e hipertricosis (23,5%; n=36). El grupo de los cambios benignos y transitorios fue el más frecuente (68,6%). Dentro de este grupo (n=105), la lesión más encontrada fue la hiperplasia sebácea con un 53,33% (n=56). Se halló asociación significativa entre la edad gestacional y la descamación (38-40 semanas p=0,035 y mayor a 40 semanas p=0,0008).
Conclusiones: la mayoría de los neonatos presentó lesiones cutáneas benignas. Es primordial el reconocimiento de las alteraciones cutáneas en recién nacidos para evitar diagnósticos incorrectos, solicitud de exámenes complementarios y tratamientos innecesarios.
Melanoma avanzado. Cambios en el paradigma terapéutico
Authors: Cisnero Daiana Mariel , Pavón Camila del Rosario , Mauri María Laura , Pedevilla Roberta , Della Giovanna Patricia Silvia
Published: April 2024

Antecedentes: la incidencia del melanoma ha aumentado en las últimas décadas. Su tratamiento en etapas avanzadas aún es un reto. El surgimiento de las terapias dirigidas y la inmunoterapia ha cambiado su pronóstico. Dentro de las terapias inmunes, los anti PD-1 mostraron resultados favorables en la sobrevida de los pacientes.
Objetivos: establecer las características poblacionales de los pacientes en nuestro centro, y comparar nuestra experiencia en el tratamiento de melanomas avanzados con inmunoterapia con los datos existentes a nivel mundial.
Diseño: se realizó un estudio retrospectivo, descriptivo y de corte transversal.
Materiales y métodos: se realizó una búsqueda de archivo fotográfico e historias clínicas de pacientes con melanoma avanzado que recibieron terapia inmune desde 2018 a 2022 en el en el consultorio interdisciplinario de Dermatología y Oncología del Hospital Nacional Posadas.
Resultados: la muestra incluyó 158 pacientes con diagnóstico de melanoma. En relación a los estadios avanzados, los estadios IIIC y IV se observaron en 54 pacientes; de estos, 18 (33%) recibieron terapia inmune. El 22% recibió pembrolizumab y el 78% nivolumab, ambos en monoterapia. El tumor primario más frecuente fue el nodular (33%). La mutación del BRAF estuvo en el 39%. Tuvo respuesta favorable el 56%, de estos, el 44% presentó respuesta completa y mejoría del ECOG al final del tratamiento en relación con quienes no respondieron al tratamiento (p<0,001). La sobrevida global al año fue del 55%.
Conclusiones: el melanoma avanzado aún es un reto terapéutico. El uso de la terapia inmune demostró altas tasas de sobrevida. En nuestra experiencia se observaron resultados positivos con inmunoterapia, con resultados de la sobrevida global similares a los publicados a nivel internacional.
Diagnóstico de las enfermedades ampollares subepidérmicas autoinmunes
Authors: Di Milia Mónica Beatriz , Label Marcelo Gabriel , Cabral Campana Luciana
Published: April 2024

Existe una gran superposición clínica, histológica e inmunológica entre las enfermedades ampollares subepidérmicas autoinmunes (EASA). El conocimiento molecular de la unión dermoepidérmica es básico para comprender este grupo de patologías. Los estudios inmunológicos son absolutamente imprescindibles para el diagnóstico de este grupo heterogéneo de enfermedades; a pesar de ello, no han hecho más que incrementar la sensación de inmenso desconocimiento que se tiene cuando se profundiza acerca de las EASA. En la práctica ocurre que casos clínicamente sospechosos de un tipo de EASA se corresponden inmunológicamente con otro. En este trabajo intentaremos clarificar algunos conceptos y brindar claves diagnósticas.
Volver a creer
Authors: Minaudo Carla
Published: April 2024

Ante todo, queremos agradecer a los lectores de Dermatología Argentina porque hemos tenido un fructífero 2023. Los comentarios en relación a los trabajos publicados son verdaderamente alentadores. Contamos con muchos seguidores locales e internacionales, ¡y vamos por más!

Como es habitual, por concurso, se han designado cuatro nuevos integrantes del Comité de Redacción que demostraron tener una formación de alto nivel, interés en la actualización y la investigación científicas, además de voluntad para participar, corregir y mejorar nuestras publicaciones.

En una realidad adversa para la medicina como la que estamos viviendo, encontrar dermatólogos interesados en el trabajo académico resulta sorprendente y esperanzador. Felicitamos a los seleccionados, y despedimos con mucho agradecimiento y afecto a los excelentes correctores salientes.

El desafío actual es impulsar el desarrollo de más artículos originales, de investigación y de educación médica.

Creemos que todavía estamos lejos de alcanzar el real potencial que los dermatólogos argentinos tenemos, el cual se basa en una historia de grandes figuras, cuyos valores y logros tienen que proyectarse, y las nuevas generaciones retomarlos para llevarlos aún más lejos.
Pústulas estériles que asientan sobre base eritematoedematosa
Authors: Calle Juan Francisco Jácome , Rufino Alejandra Duprez , Jofre Diego , Barbarulo Ana
Published: April 2024

Una paciente de 73 años, con antecedentes de diabetes mellitus tipo 2, hipertensión arterial, hipotiroidismo, insuficiencia cardíaca, dislipemia y obesidad, medicada con enalapril, metformina y levotiroxina, concurrió al Servicio de Dermatología por dermatosis pruriginosa generalizada, de 48 horas de evolución, posterior al inicio del tratamiento con amoxicilina/ácido clavulánico, en guardia externa, por presunta úlcera infectada en el tercio distal de la pierna derecha.

Al examen físico presentaba pústulas no foliculares, sobre base eritematoedematosa y fina escama en superficie, localizadas en tronco, axilas y extremidades.

El laboratorio informó: glóbulos blancos de 10.000mm3 con predominio neutrofílico, glucemia de 226 mg/dl, PCR de 20 mg/L, VSG de 30 mm/h; el resto del laboratorio, ecografía abdominal y radiografía de tórax se encontraban dentro de parámetros normales.

Anatomía patológica: espongiosis; acúmulo de neutrófilos sobre capa cornea. Pequeña ampolla con pared disgregada y vacía, moderado infiltrado inflamatorio linfocitario en banda localizado en dermis superficial, perivascular y perianexial. Capilares dérmicos dilatados.
Lavandina
Authors: Carbia Sergio Gabriel , Malah Verónica
Published: April 2024

El tratamiento que le encomendó la curandera del barrio no se lo olvida jamás. La madre lo paraba sobre la silla, cortaba ajos por la mitad y le untaba el cuerpo antes de dormir. “Imaginate lo que es dormir con olor a ajo”. Así durante 10 días, y lógicamente no dio ningún resultado. Los ungüentos que le recetaron en un hospital tampoco surtieron efecto. Las manchas en la nuca y en la cintura que le habían aparecido no se borraban. “Se me estaba yendo el color de la piel y nadie sabía nada. Mi familia veía a Charly García con su bigote blanco y no sabían siquiera que tenía ese trastorno”.
Elección múltiple: PÁPULAS Y NÓDULOS ERITEMATOSOS EN PACIENTE CON INFECCIÓN POR VIH
Authors: Coletto Gianina Anabella , Sánchez Martini Pía Florencia , Boulet María Julia
Published: April 2024

Varón de 39 años, con antecedentes de infección por VIH, internado por neumonía a germen desconocido. En el examen físico presentaba pápulas eritematosas, algunas ulceradas, de 0,5 a 1,5 cm de diámetro, en tórax y abdomen. Nódulos eritematovioláceos, de consistencia duro-elástica, de 2 cm de diámetro, en ambas piernas. Además, se constataron adenopatías generalizadas. Se realizó toma de biopsia de las lesiones cutáneas, y se observaron granulomas con centro necrobiótico e infiltrado inflamatorio mixto con múltiples cuerpos redondeados intracelulares intensamente PAS positivos. Se solicitaron estudios complementarios acorde a la sospecha diagnóstica.
Personality Traits and the Growth of Emotional Intelligence. A Systematic Evaluation
Authors: Antonopoulou Hera
Published: April 2024

Emotional intelligence (EI) and personality traits are inherent factors that shape individuals' perception, cognitive processing, and behavioral responses to emotional stimuli. This study examines the complex interplay between personality traits and emotional intelligence (EI), investigating how certain personality traits can impact the formation and expression of EI. By employing a blend of empirical investigation and theoretical examination, we evaluate the correlation between fundamental aspects of an individual's personality, namely openness, conscientiousness, extraversion, agreeableness, and neuroticism, and their emotional intelligence (EI) capacities, including self-awareness, self-regulation, motivation, empathy, and social skills. This study utilized fourteen articles acquired through a systematic search using the keywords "emotional intelligence and personality" in the Scopus and PubMed databases. An individual's personality plays a significant role in shaping their emotional intelligence, which in turn has a profound impact on multiple domains of human endeavor. Initial findings indicate that specific personality traits may facilitate developing emotional intelligence (EI), whereas others may pose obstacles that necessitate focused interventions. Acknowledging the interaction between personality and emotional intelligence (EI) presents novel opportunities for comprehensive personal growth, emphasizing the significance of customized approaches encompassing both aspects. This study emphasizes the need for a comprehensive comprehension of human behavior, advocating for approaches that accommodate the distinct interplay between an individual's personality and emotional intelligence. These strategies aim to enhance personal and interpersonal outcomes to their fullest potential.
The Contribution of Mental Capacity to Personality Formulation. An Overview
Authors: Antonopoulou Hera
Published: April 2024

Mental capacity, encompassing cognitive abilities, emotional intelligence, and reasoning skills, plays a pivotal role in shaping one's personality. This study delves into the intricate relationship between an individual's mental faculties and their personality construct. Drawing from empirical research and theoretical frameworks, we posit that mental capacity influences not only the expression of personality traits but also their adaptability and resilience in various contexts. Higher cognitive abilities may correlate with increased self-awareness, complex problem-solving, and nuanced social interactions, all of which inform personality dynamics. Furthermore, variations in emotional intelligence can determine how individuals perceive, process, and respond to emotional stimuli, directly impacting interpersonal relationships and self-concept. By understanding the profound influence of mental capacity on personality formulation, this research sheds light on the multifaceted nature of human identity, emphasizing the symbiotic interplay between cognition and character.
Decoding Public Policy Making: Unraveling the Variables and Analytical Questions for Systematic, Comprehensive Analysis
Authors: Alswaiti Lina
Published: April 2024

Purpose: Government employees, like persons in the private sector, spend a lot of their time in public service. Consequently, employee satisfaction is essential for safeguarding long-term effectiveness and efficiency in both private and public sector organizations. Creating satisfactory working environments improves employees’ work-life balance, thus higher satisfaction levels. Every year, job satisfaction levels are measured throughout all the UAE public sector institutes. This is done through a survey sent by the Dubai Government Excellence Program (DGEP) to the employees every year. With the United Arab Emirates being heralded as one of the leading countries to create ideal work environments for employees, this study aims at determining the underlying factors that affect employee satisfaction in Dubai Police traffic department.

Methodology: The study adopted descriptive research design. The research applied a purposive simple random sampling technique and probabilistic sampling technique. Data was collected on Dubai police traffic department employees. A quantitative and qualitative data analysis was conducted for the current research based on the collected data from the questionnaires circulated within the employees of police traffic department. Data were then analyzed using the Statistical Package for Social Sciences (SPSS-15) for statistical analysis. The results were presented in form of tables.

Findings: While the socio-demographic factors could be considered factors explaining job satisfaction, age and marital status are the only factors that strongly explain the relationship due to their significant result. Additionally, for the nine environmental factors, using factor analysis to determine variables that strongly explain the dependent variables, the variable under “my work directly contributes towards organization’s goals” efficiently explains the status of job satisfaction. Furthermore, execution of mandates informed by the ability of the company to address public complaints and safe work environment influences job satisfaction levels.

Unique Contribution to Theory, Practice and Policy: Although salary and work directly contribute towards an organization’s goals, companies can ensure that job levels are acquired in the right way. This way, the organization can efficiently address public complaints and promote a safe and healthy working environment. , these findings will inform further studies on behavioral management and workplace productivity in organizations.
Barreras de acceso a la salud en el cumplimiento del esquema de vacunación a menores de 5 años
Authors: González Vargas Génesis Elizabeth , Quiroz Brunes Jestin Alejandro
Published: April 2024

Introducción: las barreras de acceso son las razones reportadas para no buscar atención en salud y tienen relación con la disponibilidad, la accesibilidad y la aceptabilidad, en consecuencia, se puede afectar la asistencia de los niños a los centros de salud para la aplicación de vacunas. Objetivo: Determinar las barreras de acceso a la salud y su efecto en el cumplimiento del esquema de vacunación en niños de 0 a 5 años. Materiales y métodos: investigación descriptiva, cuantitativa y transversal, establecido por 232 padres de menores de 5 años atendidos en el vacunatorio del Centro de Salud Durán 2 de enero a junio del 2022. Para la recolección de datos se aplicó la técnica de la encuesta, como instrumento el cuestionario con una confiabilidad de Alfa de Cronbranch de 0.9, para probar la hipótesis del estudio se utilizó la prueba estadística de Chi cuadrada con un nivel de significancia de 0.05. Resultados: 69.83% presenta esquemas de vacunación incompletos, destacan de las barreras de aceptabilidad; el lenguaje técnico 67%, la accesibilidad; la frecuencia de movilización 81%, disponibilidad; cantidad de profesionales 66.38%, entre los motivos endógenos de incumplimiento destacan el no acudir en la fecha establecida, el olvido de la fecha y las reacciones posteriores. Conclusión: No se encontró relación estadística entre las barreras de salud y el cumplimiento del esquema de vacunación, sin embargo, un gran porcentaje de los niños con esquema incompleto, los padres manifestaron estar en desacuerdo con infraestructura sanitaria del vacunatorio.
Determinantes de salud en la presentación de embarazos en adolescentes de 15 a 19 años
Authors: Pérez Vargas Elsa María , Yépez Parra Aldo José Yépez Parra , Anguello Trejo Erika Cristina , Cherrez Paredes Irene Camila , Ruiz Polit Pamela Alejandra
Published: April 2024

Introducción: El embarazo en las adolescentes es un problema social y de salud que se presenta a nivel mundial, evidenciándose que los mayores riesgos los sufren las jóvenes latinoamericanas, debido a todas las precariedades a las que se tienen que enfrentar y en especial a los que presentan los sistemas de salud y la asistencia social en general. Objetivo: conocer los determinantes de salud que se evidencian en los embarazos de adolescentes con edades comprendidas entre los 15 y 19 años. Materiales y métodos: Dicha investigación tiene un soporte metodológico de tipo documental exploratorio, con información recopilada de fuentes electrónicas, constituidas en su mayoría por artículos científicos en atención al tema de referencia, material del cual se analizan y se toman los aspectos más relevantes y relacionados, para obtener de esa forma resultados que ayuden a determinar de forma acertada, las causas que originan dicha problemática y los elementos que ayudan a comprobar su incidencia y sus consecuencias. Conclusión, se pudo inferir que los determinantes de salud en presentación de embarazos en adolescentes de 15 a 19 años varían de acuerdo con múltiples factores de tipo social, económico, político, etc. y se pueden establecer a partir de diagnósticos científicamente comprobados.
El desarrollo del docente y la pandemia del año 2020 en el Perú
Authors: Pareja Pera Lidia Ysabel , Guanilo Pareja Carla Giuliana , Guanilo Paredes Carlos Enrique
Published: April 2024

El artículo trata sobre el estado en que se encontró la educación básica regular en el Perú al finalizar el año 2019, inicio de la pandemia del COVID-19, que causó la implementación de la educación virtual. El objetivo del artículo es evaluar las políticas públicas en Educación Básica Regular del Proyecto Educativo Nacional al 2021. La metodología incluye la gestión de documentos sobre las políticas públicas a partir de indicadores cualitativos, seleccionando, revisando y analizando libros impresos y digitales, artículos ubicados en Google Libros, Google Scholar, Dialnet y SciElo y notas periodísticas del período 2002 al 2020, citando y referenciando por normas APA. Se concluyó que no se lograron las metas del Proyecto, quedando en serio riesgo la culminación del año escolar, por lo que se recomienda planificar correctamente la educación.
Saúde Global e Geopolítica: a diplomacia como política pública e a relação dos BRICS no cenário de pandemia no Brasil.
Authors: Ibanez Pablo , Perreira Anna , Recio Clara
Published: April 2024

A pandemia da Covid-19 lançou novos desafios no cenário internacional e impeliu aos Estados a adoção de medidas coordenas para o seu enfrentamento. Neste contexto, verifica-se a necessidade de articulação entre políticas públicas nacionais e de cooperação internacional em prol da contenção e combate do vírus nos diferentes níveis. Para isso, discute-se o posicionamento brasileiro em questões de diplomacia de saúde, ponderando a atuação do governo federal. No plano internacional, o desenvolvimento de vacinas contra a Covid-19 criou disputas e desigualdades, demostrando que a falta de uma articulação multilateral de cooperação para a distribuição das vacinas alargou o cenário desigual de acesso a insumos. Por fim, a relação entre os BRICS, que possuem um enorme potencial de liderança em assuntos de governança global, foi e continua sendo inferior a coordenação vislumbrada, com uma mínima articulação interna e divergência de discursos.
Articulação virtuosa entre saúde-educação no enfrentamento da pandemia
Authors: Deise Lopes dos Santos Helen , Senhorinha Soares Campos Christiane
Published: April 2024

A pandemia da COVID 19 evidenciou para o mundo, e para os países subdesenvolvidos em particular, o quanto são estreitos os elos entre saúde e desenvolvimento. No Brasil o debate sobre essa correlação se ampliou com a luta pela reforma sanitária na década de 1980, pela saúde como direito universal na Constituição de 1988 e pela construção do SUS. Entretanto, o contexto pandêmico deixou explícito que não se pode mais ignorar os perigos de ter um sistema de saúde público subfinanciado, uma extrema dependência externa e a inexistência de uma política nacional de desenvolvimento. Por outro lado, também foi neste contexto que se constataram os efeitos da articulação virtuosa entre o investimento público em saúde e educação, sobretudo em regiões periféricas. Neste sentido, este artigo analisa a experiência do polo de saúde pública de Lagarto, no interior de Sergipe, enfatizando a contribuição do mesmo no enfrentamento da pandemia.
“Verdades divididas” sobre a Covid-19: o uso do canal do Telegram de Bolsonaro como registro oficial do governo
Authors: Pontalti Monari Ana Carolina
Published: April 2024

A intensificação da difusão e do consumo de informações pelas mídias sociais digitais durante a pandemia de Covid-19 tem gerado preocupação em relação à infodemia, que pode propiciar o surgimento de rumores e desinformação, além de expor o cenário de disputas narrativas pela hegemonia de sentido. Sendo assim, este artigo tem como objetivo mapear e identificar as estratégias de produção discursiva utilizadas pelo atual presidente do Brasil, Jair Bolsonaro, para mobilizar sentidos sobre a Covid-19 em seu canal oficial no Telegram. Com a análise de 251 mensagens publicadas entre janeiro e junho de 2021, foi possível observar que Bolsonaro incita e reproduz sentidos sobre a Covid-19 com base em narrativas de alerta moral, que são respaldadas por discursos de autoridade, e que ele estrutura o Telegram como mais um local para o registro de suas ações no governo federal e para a propagação de “verdades” para seus apoiadores.
10º Congreso Mundial Neuromodulación: Tecnología que mejora la atención al paciente
Authors: Andreani Juan Carlos M.
Published: April 2024

10º congreso mundial neuromodulación: Tecnología que mejora la atención al paciente
Abriendo la compuerta para el entendimiento del Dolor (Ronald Melzack, Patrick D. Wall-1965)
Authors: Acevedo González Juan Carlos
Published: April 2024

El entendimiento del dolor a través de la historia ha sido marcado por eventos que han cambiado radicalmente el curso de las investigaciones y consecuentemente de los tratamientos. Cuando Melzack y Wall desarrollaron la “Teoría de la Compuerta” lograron aclarar fenómenos elementales del dolor y crearon tópicos de investigaciones básicas y clínicas. Dieron sustento, con su teoría, a múltiples tratamientos de dolor que son la base de procedimientos que en la actualidad realizamos. Los aspectos psicológicos, el componente clínico y la base estructural anatomofisiológica fueron poco a poco conformando una de las teorías más completas de la ciencia médica y por supuesto principio básico para el mejor tratamiento del dolor. Son 50 años que se cumplen de la publicación de aquel artículo en la revista Science (Pain Mechanism: a new theory. A gate control system modulates sensory input from the skin before it evoques pain perception and response. Ronald Melzack and Patrick Wall. Science. 19 november 1965, volumen 150, number 3699), el cual ha sido reconocido hasta la actualidad como la referencia bibliográfica más utilizada en la ciencia médica en los últimos 50 años. Este análisis no es solo científico sino humano, permitiendo recordar esta teoría básica y conociendo la biografía de dos científicos.
Bloqueo Interescalénico Continuo: Bupivacaina 0,125% Versus 0,0625% para Manejo del Dolor Postoperatorio en la Cirugía Mayor de Hombro Asistida por Artroscopía
Authors: Contreras Víctor , Carbonell Paulina , Ojeda Álvaro , Elgueta Aníbal , Sanzana Edgardo
Published: April 2024

Introducción: Bloqueo Interescalénico Continuo (BIEC) se utiliza para el manejo del dolor postoperatorio de las cirugías mayores de hombro con buenos resultados. Diferentes soluciones de anestésicos locales han sido usadas.Objetivo: Evaluar la utilidad del BIEC, comparando dos concentraciones de bupivacaína asociada a sufentanil en infusión continua sobre la calidad de la analgesia postoperatoria e índice de satisfacción en pacientes intervenidos de reparación del manguito rotador del hombro (RMRH).Material y Método: Ensayo prospectivo aleatorizado en 43 pacientes, divididos en dos grupos. Grupo 1 (n=21): Bupivacaína 0,125% + Sufentanyl 1μg/ml (B 0,125+S) en infusión continua (IC) a 7 ml/hr; Grupo 2 (n=22): B 0,0625% + S, IC a 7ml/hr. El dolor posquirúrgico se registró entre las 2 y 48 horas, mediante Escala Visual Análoga (EVA). Se utilizó como analgesia de rescate morfina endovenosa. Se registró el consumo de morfina, bupivacaína, el grado de satisfacción experimentados por los pacientes y la incidencia de efectos adversos.Resultados: No hubo diferencias en los parámetros demográficos de ambos grupos. El EVA postoperatorio y el consumo de morfina entre las 4 y 48 horas fueron similares entre los grupos. El consumo de bupivacaína fue menor en el grupo 1 (p<0,005). El grado de satisfacción fue elevado en ambos grupos.Conclusiones: El BIEC es útil para el manejo del dolor postoperatorio en la RMRH. Ambas concentraciones de bupivacaína asociada a sufentanyl proveen excelente analgesia. Al utilizar B 0,0625% se disminuye el consumo de AL, sin desmejorar la calidad de la analgesia.
Literature Review on Digital Image Processing and Its Techniques
Authors: Vernekar Abhishek A. , Bhat Subramanya
Published: April 2024

Purpose: Understand the current state of knowledge in the field of digital image processing. Identify key concepts, theories, and methodologies that have been explored in previous research. Explore the various techniques and algorithms used in digital image processing. Evaluate the strengths and weaknesses of existing methods. Identify gaps or limitations in current techniques. Provide a context for the research by summarizing and synthesizing relevant studies. Show how different studies contribute to the overall understanding of digital image processing. Identify gaps in the existing literature that your research can address. Determine areas where further investigation is needed. Offer a foundation for discussion and interpretation of your results in the context of existing literature. Enable you to relate your findings to the broader field of digital image processing.
Design/Methodology/Approach: Clearly define the scope of your literature review (e.g., specific techniques, applications, or periods). State the objectives of the literature review, such as identifying trends, evaluating methodologies, or addressing research gaps. Develop a comprehensive search strategy to identify relevant literature. Utilize academic databases, journals, conferences, and other reputable sources. Use a combination of keywords, Boolean operators, and controlled vocabulary (e.g., MeSH terms) to refine search queries. Systematically review and select relevant literature based on the established criteria. Document the process, including databases searched, keywords used, and reasons for inclusion/exclusion. Identify gaps in the existing literature and propose potential avenues for future research. Discuss the implications of these gaps for the advancement of knowledge in the field
Findings/Results: Literature often discusses various image enhancement techniques such as histogram equalization, contrast stretching, and spatial filtering. Researchers explore the effectiveness of these techniques in improving image quality for different applications. Segmentation methods, including thresholding, region-based segmentation, and clustering algorithms, are frequently discussed. Object recognition and classification techniques using features like texture, color, and shape are common topics. Different image compression algorithms, such as JPEG, JPEG2000, and various wavelet-based methods, are often compared in terms of compression ratio and quality. The literature might address real-time image processing challenges and solutions, especially in applications like video surveillance, autonomous vehicles, and augmented reality.
Originality/Value: Ensure that the literature review comprehensively covers key and recent works in digital image processing. This includes foundational theories, algorithms, and applications. Identify seminal papers, landmark studies, and recent advancements to create a timeline of the field's development.
Paper Type: Review of existing literature
Close Reduction of Supracondylar fracture of humerus in children by Gravity Method
Authors: Tooba Tahira  , Muhammad Zahid Siddiq  , Waqas Ali  , Shahid Hussain
Published: April 2024

Objective: To evaluate the outcomes of employing a new technique, the gravity method, for the closed reduction of supracondylar humerus fractures (Gartland’s type II and III) in pediatric patients treated at the Trauma Center of Aziz Bhatti Shaheed Hospital Gujrat.
Methodology: This descriptive cross-sectional study was conducted at Aziz Bhatti Shaheed Hospital's Trauma Center from August 2022 to April 2023. Children under 12 years old, presenting within 48 hours of injury with closed supracondylar humerus fractures (Gartland’s Extension type II and III), were included. All patients underwent closed reduction and percutaneous pinning. Data analysis was performed using SPSS, employing means and standard deviations for quantitative variables, and frequency and percentage for qualitative variables.
Results: The mean age was 5.5 years (±1.5). Among 65 patients, there were 45 males and 20 females, with a male-to-female ratio of 1:0.4. The right humerus was affected in 28 patients (43%), while the left humerus was affected in 37 patients (57%). The gravity method successfully reduced 90% of fractures without the need for an assistant surgeon, resulting in a zero percent incidence of iatrogenic neurovascular injury. The average surgical duration was 20 minutes (ranging from 16 to 24 minutes), with an average of 7 images captured using the image intensifier. In cases where the gravity method failed, alternative closed reduction methods were employed for 10% of fractures; no open reduction was necessary.
Conclusion: The gravity method demonstrates safety and efficacy by providing accurate traction for reducing displaced supracondylar fractures without causing damage to the overlying skin or neurovascular structures around the elbow. Its applicability is particularly noteworthy in settings with a shortage of trained medical personnel and limited expertise in managing neurovascular complications.
Molecular Docking Investigation of Dioscorea alata Compounds Binding to CCKBR, CHRM3, CHRM5, and H2R for Gastric Ulcer Treatment
Authors: Makiyah Sri Nabawiyati Nurul , Usman Sherly , Ahkam Ahmad Hafidul
Published: April 2024

Gastric ulcer is a pathological condition characterized by damage to the mucosal and submucosal tissue layers of the stomach. The main proteins targeted in the treatment of gastric ulcers are CCKBR, CHRM3, CHRM5, and H2R because of their roles in the regulation of gastric acid secretion. Dioscorea alata (DA) is known to contain various active compounds with high sapogenin, diosgenin, and dioscorin content, in addition to its carbohydrate content. We investigated the potential of DA compounds to bind to these proteins in silico. Compound and protein structures were retrieved from PubChem (https://pubchem.ncbi.nlm.nih.gov), ChemSpider (http://www.chemspider.com), and the RCSB PDB (https://rcsb.org). Proteins and compounds are prepared first, and then docked to obtain the interactions that might form, and finally visualized to observe the interactions that have been constructed. The results showed that diosgenin and prosapogenin have potential as inhibitors of CCKBR and CHRM5, and diosgenin and dimethyl batatasin IV have potential as inhibitors of CHRM3 and H2R. We conclude that diosgenin, prosapogenin, and dimethyl batatasin IV in DA compounds have the potential to inhibit CCKBR, CHRM3, CHRM5, and H2R for gastric ulcer treatment. It is necessary to further study the effect of Dioscorea alata in vitro through a gastric ulcer model study.
HIGHLIGHTS   

Dioscorea alata (DA) is known to contain various active compounds with high sapogenin, diosgenin, and dioscorin content in addition to its carbohydrate content
Gastritis (gastric ulcer) is a pathological condition characterized by damage to the mucosal and sub-mucosal tissue layers of the stomach. The main proteins targeted in the treatment of gastric ulcers are CCKBR, CHRM3, CHRM5, and H2R because of their roles in the regulation of gastric acid secretion
We performed an in-silico study to investigate the potential of DA compounds to inhibit these proteins. Compound and protein structures were retrieved from PubChem, ChemSpider, and the RCSB PDB. Proteins were prepared with Swiss PDB viewer v. 4.10. Compounds were prepared with Open Babel in Cytoscape v.3.9.1. Docking was done with AutoDock Vina in PyRx v.0.9.7. Visualization was done with Discovery Studio v. 19.1
We determined that several DA compounds have the potential to act as inhibitors of CCKBR, CHRM3, CHRM5, and H2R by reviewing the predicted binding energy, competitive properties based on literature studies and the bioactivity and molecular docking analysis. The results of this study are expected to be the basis for further gastric ulcer treatment research

GRAPHICAL ABSTRACT
Physical and Chemical Characterization of Granules from 70 % Ethanol Extract of Ganitri Leaves (Eleocarpus serratus L.) using Wet Granulation Method as An Anti-Osteoporosis
Authors: Widyowati Retno , Sari Romandani Puspita , Retnowati Dini , Sholikhah Irawati , Pratama Rizki Rahmadi
Published: April 2024

Elaeocarpus serratus L. leaves have been used as an antiosteoporosis treatment and it contains active compounds such as quercetin, rutin, and myricetin. The pre-formulation study was done by making granules from 70 % ethanol extract of this plant through the wet granulation method. These granules were determined by physical characteristics including organoleptic, flow properties, real and incompressible specific gravity, moisture, particle size distribution, and chemical characteristics including flavonoid content. The organoleptic result showed that all formulas had a strong characteristic odor and a slightly bitter taste. Formula A had a dark brown color, while formulas B and C were whitish brown. Based on the results of the flow properties test, all formulas had good flow properties because they had gone through the granulation process. The compressibility index, Hausner ratio, and % moisture content displayed that all formulas met the requirements and had almost the same value. In the assay process, the average % w/w content of formula A was 0.68 ± 0.017 %, formula B was 0.66 ± 0.044 %, and formula C was 0.16 ± 0.006 %. The most optimum formula was formula C with whitish brown color, slightly bitter taste, and strong odor, 10.90 ± 0.000 g/s of flow rate, 25.41 ± 0.000 ° of angle, 4.36 ± 0.214 % of moisture content, 13.80 % compressibility index, 1.1601 of Hausner ratio, 1772.04 µm of particle average distribution, and 0.66 ± 0.044 % w/w of percent routine flavonoid content.
HIGHLIGHTS  

This study aims to determine the characteristics of granules from 70 % ethanol extract of ganitri leaves (Elaeocarpus serratus), the optimal formula to make granule preparations with active ingredients of ganitri leaves, and the levels of flavonoids using the spectrophotometer method. It also determined the characteristic physics of granule preparations including flow properties, organoleptic, moisture, particle size distribution, and real and incompressible specific gravity.

GRAPHICAL ABSTRACT
The Combination of Hvsr and Masw Methods with Landsat 8 Imagery to Assess the Changing Shoreline along the Coastal Area of Central Bengkulu
Authors: Farid Muhammad , Hadi Arif Ismul , Refrizon Refrizon , Suhartoyo Hery , Litman Litman , Fadli Darmawan Ikhlas , Putriani Eli
Published: April 2024

The Central Bengkulu Regency possesses a coastline measuring 21.8 km, situated in direct proximity to the Indian Ocean. The heightened wave and ocean current dynamics possess the capacity to induce detrimental effects in the form of coastal abrasion along the coastline. This study conducted an examination of the rate of shoreline changes resulting from coastal abrasion in Central Bengkulu Regency, Bengkulu, Indonesia. Horizontal-to-vertical spectral ratio (HVSR) analysis, multichannel analysis of surface waves (MASW), and Landsat-8 remote sensing were all used in the current investigation. The project gets started with conducting field investigations and measurements of geophysical techniques, including the collection of Landsat-8 satellite imagery spanning the period from 1990 to 2020. Additionally, an examination was conducted on the rate at which the shoreline undergoes changes in velocity. In order to determine the increase in change that occurs along coastlines over a period of several decades, a study was carried out during which Landsat-8 satellite images were analyzed. This study investigates the application of the HVSR technique for assessing the seismic vulnerability of the ground and, additionally, the MASW technique for measuring the shear wave velocity of the coastline’s soil. Both of these methodologies are compared and contrasted with one another in this research. The findings indicated that the mean pace of coastline change in Central Bengkulu Regency was 1.5 m/yr, with the maximum velocity recorded at 4.1 m/yr. This high velocity of shoreline change is correlated with the Vs30 value of MASW measurement and Kg of HVSR measurement, where the subsurface soil structure along the coast of Central Bengkulu Regency from Vs30 measurement shows that it is dominated by stiff soil structure that is susceptible to erosion. Outcomes from the study can inform decision-making processes about safeguards and preventative measures to prevent further coastal degradation.
HIGHLIGHTS  

In this paper, we present a framework using application passive and active seismic method with Landsat 8 for knowing the changing of shoreline coastal area in Central Bengkulu Indonesia
This study demonstrated that the high velocity of the shifting shoreline is correlated with Vs30 and Kg values
The subsurface soil structure is predominantly composed of stiff soil, and the changing shoreline starts at 1.5 mm/yr, which makes the coast of Central Bengkulu vulnerable to erosion

GRAPHICAL ABSTRACT
Biofilm Production and Porin Permeability Activity in Clinical Isolates of Ciprofloxacin-Resistant Klebsiella pneumoniae in the Tertiary Hospital in Purwokerto, Indonesia
Authors: Sulistiyawati Indah , Siswandari Wahyu , Joko Wahyono Daniel
Published: April 2024

World Health Organization reports that the current use of ciprofloxacin as a broad-spectrum antibiotic shows a pattern of high bacterial resistance in many countries. Klebsiella pneumoniae is known as a Gram-negative bacterium that most often causes infection and is resistant to antibiotics. This study aimed to find patterns of resistance mechanisms based on biofilm production and porin permeability activity in K. pneumoniae clinical specimens from patients at RSUD Prof. Dr Margono Soekardjo Purwokerto, Indonesia. Several isolates of ciprofloxacin-resistant K. pneumoniae were isolated from clinical specimens of blood, sputum, urine, pus, stool and pleural fluid from August to October 2022. Identification and sensitivity testing of K. pneumoniae to ciprofloxacin were performed using Vitek® 2 Compact. A test for biofilm production is carried out by measuring optical density (OD) with a microplate at a wavelength of 630 nm. The porin permeability activity was determined using the value of the minimum inhibitory concentration (MIC) by the LC-MS spectrophotometry method at a wavelength of 630 nm. The results showed that 72 (47 %) isolates were resistant to ciprofloxacin. Among them, 41.3 % (24/58) of ciprofloxacin-resistant K. pneumoniae were able to produce strong biofilm. Porin permeability is indicated by MIC values of 1, 2 and 4 mg/L with bacterial cell counts of 32×106, 19×106 and 34×106 CFU/mL, respectively. This number decreased from the initial control with a bacterial cell count of 10.15×107 CFU/mL. Analysis of the correlation between the significance of biofilm production and the number of bacterial cells indicated that biofilm formation was related to the number of bacterial cells (R = 0.628, p ≤ 0.05). In conclusion, the resistance mechanism of ciprofloxacin-resistant K. pneumoniae involves biofilm production and decreased porin permeability activity.
HIGHLIGHTS  

Major resistance mechanisms in pneumoniae decreased cell permeability from porin activity and biofilm formation
Bacterial outer membrane permeability to antimicrobial substances influences inherent resistance. Bacteria produce biofilm to increase their resistance to antibiotics. Porins are non-specific diffusion transport proteins that play a part in the antibiotic resistance process
The evolutionary development in the case of antibiotic resistance has an impact on the emergence of understanding in new perspective patterns on how to overcome health problems related to antibiotic resistance

GRAPHICAL ABSTRACT