bluuebunny/crossref_metadata_2025 huggingface dataset:
Phosphorus saturation index and water-extractable phosphorus in high-legacy phosphorus soils in southern British Columbia, Canada
Authors: Messiga Aimé J. , Lam Camellia , Li Yunkun
Published: March 2021

Understanding of the risk of phosphorus (P) loss to the environment is crucial to monitor soil P and implement policies for P management. We assessed P sorption characteristics and adapted a P saturation index (PSI) for silage corn and blueberry fields in south coastal British Columbia (BC), Canada. We used 284 composite soil samples with contrasting P levels collected from eight silage corn and 23 blueberry fields across south coastal BC. The P sorption maximum (Smax) varied between 982 and 2532 mg P·kg−1 and was influenced by aluminum concentration and organic matter content. The degree of P saturation was related to water-extractable P (Pw) by a quadratic regression with R2 = 0.85. A critical Pw = 3.7 mg·kg−1 was established across the two cropping systems. The silage corn fields with pH > 5.5 had critical PSI value of 10.4%, and blueberry fields with pH < 4.7 had critical PSI value of 18.0%. These results showed that the risk of P loss from soil in the silage corn was high, but it was low for blueberry because the critical PSI for silage corn fields was lower than for blueberry fields, and therefore, saturation would be more easily reached, even though more P is applied to blueberry fields. The combination of a critical PSI and Pw as agri-environmental indicators will help farmers and professionals to identify fields with risk of P loss, to implement a nutrient management plan, and to monitor how this risk changes with time.
Urbanization and stream ecosystems: the role of flow hydraulics towards an improved understanding in addressing urban stream degradation
Authors: Anim Desmond Ofosu , Banahene Patrick
Published: March 2021

Catchment urbanization is widely recognised as a primary driver of stream degradation by increasing stormwater runoff, which causes major changes to key ecosystem processes. Reinstating the “natural” hydrogeomorphic conditions is central in designing successful, self-sustaining restoration actions; however, addressing urban stream degradation by re-establishing the hydrogeomorphic conditions remains a challenge, and comparatively limited measurable progress has been observed, particularly in achieving ecological objectives. This review articulates that stream restoration goals might be better achieved when management measures take a broader approach that considers anticipated hydraulic condition effects that liaise relationships between flow and ecology. The study argues that fluvial systems are characterised by complex and dynamic ecosystem processes primarily governed by the hydraulic conditions (e.g., velocity, depth, shear stress); thus, as the practice of addressing urban stream restoration becomes increasingly common, it is critical to explore and understand the anticipated response of the hydraulic conditions. It describes how hydraulic regime consideration provides further opportunity for a holistic approach to urban stream management given their capacity to account for multiple ecological and geomorphic objectives. This review suggests that developing suitable flow–biota–ecosystem processes nexus is critical to addressing urban stream degradation, and hydraulic consideration in restoration actions provides an important step towards that. It discusses opportunities to evolve management actions to achieve restoration goals by highlighting how the management of the two key levers (addressing altered flow regime and morphology) to improve the hydraulic conditions can help to address the urban stream disturbance.
Study on the anomalous quartic $$W^+W^-\gamma \gamma $$ couplings of electroweak bosons in $$e^-p$$ collisions at the LHeC and the FCC-he
Authors: Gutiérrez-Rodríguez A. , Hernández-Ruíz M. A. , Gurkanli E. , Ari V. , Köksal M.
Published: March 2021

In this paper, a study is carried out on the $$e^-p \rightarrow e^-\gamma ^* p \rightarrow p W^-\gamma \nu _e$$

e
-

p
→

e
-

γ
∗

p
→
p

W
-

γ

ν
e

production to probe quartic $$W^+W^-\gamma \gamma $$

W
+

W
-

γ
γ

couplings at the Large Hadron electron Collider (LHeC) with $$\sqrt{s}= 1.30, 1.98\,\hbox {TeV}$$

s

=
1.30
,
1.98

TeV

and at the Future Circular Collider-hadron electron (FCC-he) with $$\sqrt{s}= 3.46, 5.29\,\hbox {TeV}$$

s

=
3.46
,
5.29

TeV

. Production cross-sections are determined for both at leptonic and hadronic decay channels of the W-boson. With the data from future $$e^-p$$

e
-

p

colliders, it is possible to obtain sensitivity measures at $$95\%$$

95
%

C.L. on the anomalous $$f_ {M,i}/\Lambda ^4$$

f

M
,
i

/

Λ
4

and $$ f_ {T,j}/\Lambda ^4$$

f

T
,
j

/

Λ
4

couplings which are competitive with the limits obtained by the LHC, as well as with others limits reported in the literature. The production mode $$e^-p \rightarrow e^-\gamma ^* p \rightarrow p W^-\gamma \nu _e $$

e
-

p
→

e
-

γ
∗

p
→
p

W
-

γ

ν
e

in $$e^-p$$

e
-

p

collisions offers a window for study the quartic $$W^+W^-\gamma \gamma $$

W
+

W
-

γ
γ

electroweak bosons couplings at the LHeC and the FCC-he, which provides a much cleaner collision environment than the LHC.
First-principles study on the magnetic properties of IB group transition metal-doped MoS2
Authors: Wang Duo , Yang Lu , Cao Jianan
Published: March 2021

In this paper, a first-principles calculation method based on density functional theory is used to study the effect of substitutional doping of Au, Ag, and Cu at Mo site on the magnetic properties of the single-layer MoS2system. It is found that the Au, Ag, and Cu-doped systems can all exhibit ferromagnetic properties at room temperature. The calculation of defect formation energy and hybrid orbital theory confirms that the system can exist stably. After comparing the energy difference, it is concluded that the magnetic properties of the doped system are more stable in the spin-polarized state. The magnetic moment contributed by impurity atoms is limited. The Mo and S atoms near the impurity atoms are induced by the impurity atoms, and the magnetic moment of the system is mainly produced by this method. There is a ferromagnetic coupling between impurity atoms and surrounding Mo atoms.
Predicting of Open Source Software Component Reusability Level Using Object-Oriented Metrics by Taguchi Approach
Authors: Saini G. L. , Panwar Deepak , Kumar Sandeep , Singh Vijander , Poonia Ramesh Chandra
Published: March 2021

Component-based software development (CBSD) is an efficient approach used by software developers to develop new software. The commercial off the shelf (COTS) and open-source software (OSS) are two styles to implement CBSD. The COTS provides the interface and depicts the black-box behavior, but does not support several software quality characteristics. On the other hard, OSS is a more efficient approach compared to COTS due to its source code availability. This research aims to identify the reusability level of OSS components from an online repository of OSS. The OSS components are classified based on Chidamber and Kemerer reusability metrics (CK-metrics). This paper proposed a mathematical model to establish the relationship between the reusability of CK-metrics. Reusability level of OSS component has been measured and most effective CK-metrics obtained by applying the Taguchi design and analysis of variance (ANOVA). The input parameters for the experimental design are evaluated based on the OSS repository. Performance analysis has been carried out based upon the interaction effect between the reusability of CK-metrics. Main effect plots are created to identify the most reusable component of the OSS. The genetic algorithm (GA) is used to predict the optimized value of the different control parameters. The results indicate that the OSS component reusability level is 0.698194. The reusability of software has a significant effect on the quality of software. The quality of software can be improved by increasing the reusability of software components.
An Empirical Study of Students’ Perceptions on the Setup and Grading of Group Programming Assignments
Authors: Aivaloglou Efthimia , Meulen Anna van der
Published: March 2021

Courses in computer science curricula often involve group programming assignments. Instructors are required to take several decisions on assignment setup and monitoring, team formation policies, and grading systems. Group programming projects provide unique monitoring opportunities due to the availability of both product and process data, as well as challenges in team composition, with students of varying levels of prior programming experience. To gain insights into the experiences and perceptions of students about the assignment setup and grading policies in group programming projects, we interviewed 20 computer science students from four universities. The thematic analysis highlighted factors in group composition that are considered important, as well as advantages and disadvantages of the self-selection of the teams. It also indicated three grading strategies experienced by the students, namely, being assigned the same group grade, individual grades distributed by the instructor, and grade distribution determined by the team, with perceptions about them varying greatly. Several practices for monitoring team contributions were identified. Checking the source code repositories was considered useful in recognizing slacking members, but automated metrics are not always representative of the work distribution. The analysis also uncovered student perceptions on the grading factors for programming assignments, including coding efficiency and skill.
Covid-19 and challenges for learning-technology adoption in Pakistan
Authors: Iqbal Muhammad Zahid , Campbell Abraham G.
Published: March 2021

The
Interactions
website (interactions.acm.org) hosts a stable of bloggers who share insights and observations on HCI, often challenging current practices. Each issue we'll publish selected posts from some of the leading and emerging voices in the field.
Accelerated Degradation Protocols for Iridium-Based Oxygen Evolving Catalysts in Water Splitting Devices
Authors: Spöri Camillo , Brand Cornelius , Kroschel Matthias , Strasser Peter
Published: March 2021

Hydrogen production by proton exchange membrane (PEM) water electrolysis is among the promising energy storage solutions to buffer an increasingly volatile power grid employing significant amounts of renewable energies. In PEM electrolysis research, 24 h galvanostatic measurements are the most common initial stability screenings and up to 5,000 h are used to assess extended stability, while commercial stack runtimes are within the 20,000–50,000 h range. In order to obtain stability data representative of commercial lifetimes with significantly reduced test duration an accelerated degradation test (ADT) was suggested by our group earlier. Here, we present a study on the broad applicability of the suggested ADT in RDE and CCM measurements and showcase the advantage oftransientoverstaticoperation for enhanced catalyst degradation studies. The suggestedADT-1.6Vprotocol allows unprecedented, reproducible and quick assessment of anode catalyst long-term stability, which will strongly enhance degradation research and reliability. Furthermore, this protocol allows to bridge the gap between more fundamental RDE and commercially relevant CCM studies.
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding
Authors: Zeugolis Dimitrios I.
Published: March 2021

The development of therapeutic regenerative medicine and accurate drug discovery cell-based products requires effective, with respect to obtaining sufficient numbers of viable, proliferative, and functional cell populations, cell expansion ex vivo. Unfortunately, traditional cell culture systems fail to recapitulate the multifaceted tissue milieu in vitro, resulting in cell phenotypic drift, loss of functionality, senescence, and apoptosis. Substrate-, environment-, and media-induced approaches are under intense investigation as a means to maintain cell phenotype and function while in culture. In this context, herein, the potential of macromolecular crowding, a biophysical phenomenon with considerable biological consequences, is discussed.
Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy
Authors: Boschetti Elisa , D’Angelo Roberto , Tardio Maria Lucia , Costa Roberta , Giordano Carla , Accarino Anna , Malagelada Carolina , Clavenzani Paolo , Tugnoli Vitaliano , Caio Giacomo , Righi Valeria , Garone Caterina , D'Errico Antonietta , Cenacchi Giovanna , Dotti Maria Teresa , Stanghellini Vincenzo , Sternini Catia , Pironi Loris , Rinaldi Rita , Carelli Valerio , De Giorgio Roberto
Published: March 2021

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is characterized by a genetically driven defect of thymidine phosphorylase, a multitask enzyme playing a role also in angiogenesis. Indeed, major gastrointestinal bleedings are life-threatening complications of MNGIE. Thus, we focused on jejunal submucosal vasculature and showed intestinal microangiopathy as a novel feature occurring in this disease. Notably, vascular changes were associated with neuromuscular abnormalities, which may explain gut dysfunction and help to develop future therapeutic approaches in MNGIE.
Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema
Authors: Kruk Dennis M. L. W. , Wisman Marissa , Bruin Harold G. de , Lodewijk Monique E. , Hof Danique J. , Borghuis Theo , Daamen Willeke F. , van Kuppevelt Toin H. , Timens Wim , Burgess Janette K. , ten Hacken Nick H. T. , Heijink Irene H.
Published: March 2021

Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD). We hypothesized that lung-derived MSCs (LMSCs) from patients with emphysema are hampered in their repair capacity, either intrinsically or due to their interaction with the damaged microenvironment. LMSCs were isolated from the lung tissue of controls and patients with severe emphysema and characterized at baseline. In addition, LMSCs were seeded onto control and emphysematous decellularized lung tissue scaffolds and assessed for deposition of extracellular matrix (ECM). We observed no differences in surface markers, differentiation/proliferation potential, and expression of ECM genes between control- and COPD-derived LMSCs. Notably, COPD-derived LMSCs displayed lower expression of FGF10 and HGF messenger RNA (mRNA) and hepatocyte growth factor (HGF) and decorin protein. When seeded on control decellularized lung tissue scaffolds, control- and COPD-derived LMSCs showed no differences in engraftment, proliferation, or survival within 2  wk, with similar ability to deposit new matrix on the scaffolds. Moreover, LMSC numbers and the ability to deposit new matrix were not compromised on emphysematous scaffolds. Collectively, our data show that LMSCs from patients with COPD compared with controls show less expression of FGF10 mRNA, HGF mRNA and protein, and decorin protein, whereas other features including the mRNA expression of various ECM molecules are unaffected. Furthermore, COPD-derived LMSCs are capable of engraftment, proliferation, and functioning on native lung tissue scaffolds. The damaged, emphysematous microenvironment as such does not hamper the potential of LMSCs. Thus, specific intrinsic deficiencies in growth factor production by diseased LMSCs may contribute to impaired alveolar repair in emphysema.
Thrombosis as the First Manifestation of Granulomatosis with Polyangiitis Disease in an Adolescent
Authors: Jari Mohsen
Published: March 2021

Background. Granulomatosis with polyangiitis disease (GPA) is a rare vasculitis characterized by granulomatous inflammation of respiratory tracts, glomerulonephritis, and vasculitis of other organs. Case Presentation. A 13-year-old girl was referred due to swelling and pain on her left arm. The Doppler and compression ultrasonography showed noncompressible left brachial and axillary vein thrombosis. Sinus computed tomography (CT) demonstrated pansinusitis, and spiral chest CT showed alveolar hemorrhage. Laboratory tests showed hematuria, proteinuria, and highly positive antineutrophil cytoplasmic antibody (cANCA). Laboratory tests of coagulopathy were normal. The patient was recognized as a case of GPA. Conclusion. Although GPA is not frequently associated with thrombosis especially in children, this is the first report that shows thrombosis may be the first manifestation of GPA in an adolescent.
Optimal Fractional Order Based on Fuzzy Control Scheme for Wind Farm Voltage Control with Reactive Power Compensation
Authors: Elyaalaoui Kamal , Labbadi Moussa , Ouassaid Mohammed , Cherkaoui Mohamed
Published: March 2021

Voltage stability margin is ensured through the reactive power resources. In order to generate the reactive power references and ensure the low-voltage ride-through (LVRT) control of a wind farm system based on squirrel cage induction generator, this paper proposed an optimal control approach based on fractional-order (FO) PI-fuzzy-PI (FOPI-fuzzy-FOPI) controller. The proposed control method ensures, also, the demand for active and reactive power predetermined by the transmission system operator (TSO) and satisfies the grid code recommendations. In order to achieve a faster tracking of state variables of the system, the FO operators are optimized using the particle swarm optimization algorithm (PSOA). Using FO operator and PSOA, the responses of the system can be improved. The proposed controller provides additional parameters for better tracking performance and faster convergence can be achieved. Numerical simulation results are presented to analyze the advantages of the proposed control approach to design a physically, realizable controller. The present results are compared with various control methods to show the superiority of the method proposed in this paper.
A Cross-Sectional Study on Ultrasonographic Measurements of Parotid Glands in Type 2 Diabetes Mellitus
Authors: Gupta Abhishek , Ramachandra Vijayalakshmi Kondajji , Khan Mubeen , Jha Kumari Sonam , Vedaraju K. S. , Channaiah Nirmala Alagudu
Published: March 2021

Background. Diabetes mellitus is a metabolic disease which is seen increasing globally and is diagnosed and monitored on basis of invasive blood investigations. Salivary glands are affected in diabetes mellitus. The objective of this study was to assess ultrasonographic measurements of parotid glands and correlate with the glycosylated hemoglobin levels in type 2 diabetic mellitus and duration of type 2 diabetic mellitus and treatment regimens. Materials and Methods. This study was conducted on 50 subjects of type 2 diabetes mellitus and on 50 healthy controls. After HbA1C analysis of selected individuals, 100 individuals were grouped into group I (above 5.7) and group II (below 5.7). Ultrasonographic measurements (length (L), transverse dimension (TD), depth lateral to the mandible (DLM), and depth dorsal to the mandible (DDM)) of bilateral parotid glands were calculated. Statistical analysis was done using the chi-square test of significance and Spearman correlation coefficients. Results. On correlation with measurement of right (L, DLM, DDM) and left (TD, DLM, DDM) of parotid glands with duration of type 2 diabetes mellitus, we found a moderate positive relationship, whereas as for right (TD) and left (L), we found a low-positive relationship. Similarly, for right (L, TD, DLM, DDM) and left (TD, DDM) parotid glands with HbA1C, we found a low-positive relationship, whereas for left parotid gland (L, DLM) with HbA1C, we found a moderate positive relationship. The mean DLM of right and left parotids in the insulin group was found to be slightly more than that in the combined group which was statistically insignificant. Conclusion. Ultrasonographic measurements of parotid glands were found to be higher in study subjects as compared to control subjects, and they increased with increased HbA1C levels; also, there was no difference in treatment regimen. Ultrasonography could be a prospective diagnostic test for detection and monitoring of diabetes mellitus, and still further studies are required for this.
Clustering and Prediction Analysis of the Coordinated Development of China’s Regional Economy Based on Immune Genetic Algorithm
Authors: Yang Yang
Published: March 2021

Since the opening of the economy, China’s regional economy has developed rapidly, the overall national strength has been increasing, and the people’s living standards have been continuously improved. The issue of coordinated regional development has become an important issue in today’s society. Genetic algorithm is a kind of prediction algorithm that has developed rapidly in recent years and is widely used. However, when solving engineering prediction problems, there are often problems such as premature convergence and easiness to fall into local optimal solutions. Therefore, on the basis of studying the related theories of genetic algorithm and artificial immune algorithm, this paper uses the advantages of the two algorithms, combines the two algorithms, and proposes an improved algorithm for genetic algorithm‐adaptive immune genetic algorithm. Taking genetic algorithm as the basic framework, the operators and selection methods of artificial immune algorithm are integrated. Using the adaptive concept, the formulas of adaptive crossover probability and mutation probability are innovatively designed. Compared with the fixed value of the immune genetic algorithm, the introduction of the adaptive concept can intelligently adjust the optimization process and increase the optimization speed. Considering the double uncertain factors of product market demand and waste product recycling in the remanufacturing supply chain system, the maximization of logistics network operating profit, the minimization of environmental impact, and the maximization of customer satisfaction are the forecast goals. The market demand of uncertain products is effectively controlled through the option contract mechanism, and a multiobjective forecasting model based on the option contract mechanism is established. According to the characteristics of the model, an improved immune genetic algorithm is designed to solve the problem, and the effectiveness of the immune genetic algorithm is verified through an example.
Atypical Microbiological Feature of Infectious Endophthalmitis on Jeju Island: A 10-Year Study at a Single Tertiary Referral Center
Authors: Park Joong Hyun , Kim Dong Yoon , Ha Ahnul , Ma Dae Joong , Lee Hye Jin , Jeong Jinho , Kim Jin Young
Published: March 2021

Background. To analyze the microbiological causes of infectious endophthalmitis on an isolated island over ten years. Methods. A retrospective review of the medical records of 49 eyes clinically diagnosed with infectious endophthalmitis between January 2009 and December 2018 was done. The subjects were recruited from a single tertiary referral center on Jeju Island. The baseline characteristics of all subjects were investigated, and a culture examination was performed. The isolated pathogens were analyzed to determine how their microbiological features differed from those in regions with different geographical conditions. Results. Of the 49 eyes, causative microorganisms were identified in 27 eyes (55.1%). Bacteria were found in 24 cases and fungi in 3 cases. Among the exogenous causes, Staphylococcus species (Staphylococcus aureus, S. epidermidis, and S. hominis) were the most common pathogens (7 cases). Achromobacter xylosoxidans was the second most common causative pathogen (4 cases) followed by Moraxella species (3 cases). The most frequent endogenous origin was due to Klebsiella pneumoniae (6 cases). The subjects were divided into two groups according to the treatment results and analyzed for predisposing factors related to visual outcomes. The presence of diabetes mellitus (

P

 = 0.038) and initial visual acuity (

P

 ≤ 0.001) were significant predisposing factors for visual outcomes. Conclusion. The causative microorganisms of endogenous endophthalmitis on Jeju Island were not different from those reported previously. However, isolated exogenous microorganisms were different from those reported in other studies from inland areas. A high incidence and atypical clinical features of Achromobacter xylosoxidans and Moraxella in exogenous endophthalmitis were observed, reflective of the distinct climatic features of Jeju Island: high humidity and temperature. Therefore, considering the causative microorganisms of exogenous endophthalmitis, it may be assumed that the causative microorganisms of exogenous endophthalmitis and its clinical manifestations differ according to the region.
Research on Transmission Line Fault Location Based on the Fusion of Machine Learning and Artificial Intelligence
Authors: Liu Xiao-Wei
Published: March 2021

After a transmission line fails, quickly and accurately find the fault point and deal with it, which is of great significance to maintaining the normal operation of the power system. Aiming at the problems of low accuracy of traditional traveling wave fault location methods and many affected factors, this paper relies on distributed traveling wave monitoring points arranged on transmission lines to study methods to improve the accuracy of traveling wave fault location on transmission lines. First, when a line fails, a traveling wave signal that moves to both ends will be generated and transmitted along the transmission line. We use the Radon transform algorithm to process the traveling wave signal. Then, this paper uses ant colony algorithm to analyze and verify the location and extent of transmission line faults and then optimizes high-precision collection and processing. Finally, the simulation distance measurement is carried out on double-terminal transmission lines and multiterminal transmission lines (T-shaped lines) with branches. The results show that, for double-ended transmission lines, the algorithm increases the speed of matrix calculations and at the same time makes the fault location error of the transmission grid still maintain the improved effect.
Assessment of Developmental and Reproductive Fitness of Dengue‐Resistant Transgenic Aedes aegypti and Improvement of Fitness Using Antibiotics
Authors: Ramyasoma Hewawasam Patuwatha Badathuruge Kalindu Dulanja , Gunawardene Yasanthi Illika Nilmini Silva , Hapugoda Menaka , Dassanayake Ranil Samantha
Published: March 2021

Background. Genetic modification offers opportunities to introduce artificially created molecular defence mechanisms to vector mosquitoes to counter diseases causing pathogens such as the dengue virus, malaria parasite, and Zika virus. RNA interference is such a molecular defence mechanism that could be used for this purpose to block the transmission of pathogens among human and animal populations. In our previous study, we engineered a dengue‐resistant transgenic Ae. aegypti using RNAi to turn off the expression of dengue virus serotype genomes to reduce virus transmission, requiring assessment of the fitness of this mosquito with respect to its wild counterpart in the laboratory and semifield conditions. Method. Developmental and reproductive fitness parameters of TM and WM have assessed under the Arthropod Containment Level 2 conditions, and the antibiotic treatment assays were conducted using co‐trimoxazole, amoxicillin, and doxycycline to assess the developmental and reproductive fitness parameters. Results. A significant reduction of developmental and reproductive fitness parameters was observed in transgenic mosquito compared to wild mosquitoes. However, it was seen in laboratory‐scale studies that the fitness of this mosquito has improved significantly in the presence of antibiotics such as co‐trimoxazole, amoxicillin, and doxycycline in their feed. Conclusion. Our data indicate that the transgenic mosquito produced had a reduction of the fitness parameters and it may lead to a subsequent reduction of transgenic vector density over the generations in field applications. However, antibiotics of co‐trimoxazole, amoxicillin, and doxycycline have shown the improvement of fitness parameters indicating the usefulness in field release of transgenic mosquitoes.
Event-Triggered Adaptive Sliding Mode Attitude Containment Control for Microsatellite Cluster under Directed Graph
Authors: Guo Fengzhi , Zhang Shijie , Zhang Tingting , Zhang Anhui
Published: March 2021

In order to investigate the attitude containment control problem for a microsatellite cluster, an event-triggered adaptive sliding mode attitude containment control algorithm is proposed for the satellite cluster flight system under directed topology, so that attitude of followers asymptotically converges to the convex hull formed by the leaders’ orientations. At first, the event-triggered control strategy is introduced into the attitude containment control problem for the microsatellite cluster. The triggering condition consisting of state-dependent and time-dependent function is designed to adjust control period and avoid the Zeno behaviour. When the function value meets the triggering condition, the event is triggered, state information is sampled, control law is computed, and actuators are updated, while the control action performed in nontriggering time is the same as the previous triggering instant. Then, in the presence of model uncertainties and external disturbances, an event-triggered adaptive sliding mode attitude containment control algorithm is presented under directed topology, and sufficient and necessary conditions for the followers to enter into the target area formed by the leaders are given. Furthermore, cell partitions from graph theory are employed to investigate the influence of information topology on steady states of followers, which provides theoretical basis for orientation design of cluster satellites. Finally, simulation results show that the proposed control strategy could reduce control execution frequency, as well as ensure the similar control performance with the time-triggered one, and followers belonging to the same cell have the same steady states.
A Study on the Mechanism of Dynamic Pressure during the Combinatorial Key Strata Rock Column Instability in Shallow Multi‐coal Seams
Authors: Zhang Jie , Wang Bin , Bai Wenyong , Yang Sen
Published: March 2021

In order to study the pressure changes and support failure in mining face under concentrated coal pillar in shallow coal seam, the concentrated coal pillar in 30105 working face of Nan Liang Coal Mine was selected as the research object. In this study, the mechanism of dynamic mine pressure in mining face under concentrated coal pillar was investigated through multiple simulation experiments, numerical simulations, and theoretical analysis. The results of similar simulation experiment indicate that the dynamic mine pressure occurred at 25 m under the concentrated coal pillar and 7 m beyond the coal pillar. The strata roof was observed with sliding down, resulting in collapse and severe fractures commonly seen in rock column. The overlying strata caused the overall subsidence and collapse synchronously, resulting in the sudden increase of the resistance of the support in the working face, and the dynamic load coefficients reach 3.4 and 3.5. The theoretical analysis indicates that the two hard strata in the overlying strata of 3−1 coal meet the theoretical criterion of the combined key strata with the concentrated coal pillar of 2−2 coal in the weak interlayer of the combined key strata. The combined key strata bear the load of the whole overlying strata. The sliding instability featured with the rock column‐type fracture located in the combined key strata is considered as the primary trigger of the abnormal resistance of the support and the dynamic mine pressure in the mining face under the concentrated coal pillar. The dynamic pressure model of “combination key strata—immediate roof‐support” was established, along with the dynamic load coefficient calculation related to the rock column‐type fracture and instability. The characteristics of dynamic load coefficient of the rock column‐type fracture and instability under different overlying rock structure conditions were analyzed, providing references and insights into mining under similar geographic conditions.
An Efficient Feature Weighting Method for Support Vector Regression
Authors: Xie Minghua , Xie Lili , Zhu Peidong
Published: March 2021

Support vector regression (SVR) is a powerful kernel-based method which has been successfully applied in regression problems. Regarding the feature-weighted SVR algorithms, its contribution to model output has been taken into account. However, the performance of the model is subject to the feature weights and the time consumption on training. In the paper, an efficient feature-weighted SVR is proposed. Firstly, the value constraint of each weight is obtained according to the maximal information coefficient which reveals the relationship between each input feature and output. Then, the constrained particle swarm optimization (PSO) algorithm is employed to optimize the feature weights and the hyperparameters simultaneously. Finally, the optimal weights are used to modify the kernel function. Simulation experiments were conducted on four synthetic datasets and seven real datasets by using the proposed model, classical SVR, and some state-of-the-art feature-weighted SVR models. The results show that the proposed method has the superior generalization ability within acceptable time.
Experimental Chronic Prostatitis/Chronic Pelvic Pain Syndrome Increases Anxiety‐Like Behavior: The Role of Brain Oxidative Stress, Serum Corticosterone, and Hippocampal Parvalbumin‐Positive Interneurons
Authors: Šutulović Nikola , Grubač Željko , Šuvakov Sonja , Jerotić Djurdja , Puškaš Nela , Macut Djuro , Rašić-Marković Aleksandra , Simić Tatjana , Stanojlović Olivera , Hrnčić Dragan
Published: March 2021

Mechanisms of the brain‐related comorbidities in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still largely unknown, although CP/CPPS is one of the major urological problems in middle‐aged men, while these neuropsychological incapacities considerably diminish life quality. The objectives of this study were to assess behavioral patterns in rats with CP/CPPS and to determine whether these patterns depend on alterations in the brain oxidative stress, corticosterone, and hippocampal parvalbumin‐positive (PV+) interneurons. Adult male Wistar albino rats from CP/CPPS (intraprostatic injection of 3% λ‐carrageenan, day 0) and sham (0.9% NaCl) groups were subjected to pain and anxiety‐like behavior tests (days 2, 3, and 7). Afterwards, rats were sacrificed and biochemical and immunohistochemical analyses were performed. Scrotal allodynia and prostatitis were proven in CP/CPPS, but not in sham rats. Ethological tests (open field, elevated plus maze, and light/dark tests) revealed significantly increased anxiety‐like behavior in rats with CP/CPPS comparing to their sham‐operated mates starting from day 3, and there were significant intercorrelations among parameters of these tests. Increased oxidative stress in the hippocampus, thalamus, and cerebral cortex, as well as increased serum corticosterone levels and decreased number of hippocampal PV+ neurons, was shown in CP/CPPS rats, compared to sham rats. Increased anxiety‐like behavior in CP/CPPS rats was significantly correlated with these brain biochemical and hippocampal immunohistochemical alterations. Therefore, the potential mechanisms of observed behavioral alterations in CP/CPPS rats could be the result of an interplay between increased brain oxidative stress, elevated serum corticosterone level, and loss of hippocampal PV+ interneurons.
Croup Is One of the Clinical Manifestations of Novel Coronavirus in Children
Authors: Kamali Aghdam Mojtaba , Shabani Mirzaee Hosein , Eftekhari Kambiz
Published: March 2021

The manifestations of novel coronavirus are diverse and can manifest through respiratory, gastrointestinal, and even nervous symptoms. Respiratory involvement is usually an upper tract infection or pneumonia but can also present as other forms of pulmonary disorders. A 3-year-old boy presented with cough, hoarseness, and stridor. He was treated with dexamethasone and nebulized adrenaline and a clinical diagnosis of croup was established. After treatment, his symptoms improved for a short time, but suddenly cough exacerbated and was accompanied by respiratory failure and seizures. He was then intubated and mechanically ventilated. Because of the coronavirus epidemic, Reverse-Transcription Polymerase Chain Reaction (RT-PCR) assay was taken from the pharyngeal secretions and was positive. The child was isolated. Due to excessive respiratory secretions and worsening of the general condition, bronchoscopy was performed depicting an image compatible with bacterial tracheitis. He was treated with broad-spectrum antibiotics, antivirals, and supportive care. Finally, after 4 weeks of treatment, the child was discharged in good general condition. Croup is one of the respiratory symptoms of novel coronavirus and can be a risk factor for bacterial tracheitis. Therefore, the presence of clinical manifestations of croup indicates the need for coronavirus PCR testing.
Comprehensive Molecular Characterization and Response to Therapy in Fumarate Hydratase–Deficient Renal Cell Carcinoma
Authors: Gleeson Jack P. , Nikolovski Ines , Dinatale Renzo , Zucker Mark , Knezevic Andrea , Patil Sujata , Ged Yasser , Kotecha Ritesh R. , Shapnik Natalie , Murray Samuel , Russo Paul , Coleman Jonathan , Lee Chung Han , Stadler Zsofia K. , Hakimi A. Ari , Feldman Darren R. , Motzer Robert J. , Reznik Ed , Voss Martin H. , Chen Ying-Bei , Carlo Maria I.
Published: March 2021

Purpose:

Fumarate hydratase–deficient renal cell carcinoma (FH-RCC) is a rare, aggressive form of RCC associated with hereditary leiomyomatosis and RCC syndrome. Evidence for systemic therapy efficacy is lacking.

Experimental Design:

We studied clinical and genomic characteristics of FH-RCC, including response [objective response rate (ORR)] to systemic therapies and next-generation sequencing (NGS). Patients with metastatic FH-RCC, defined by presence of pathogenic germline or somatic FH mutation plus IHC evidence of FH loss, were included.

Results:

A total of 28 of 32 included patients (median age 46; range, 20–74; M:F, 20:12) underwent germline testing; 23 (82%) harbored a pathogenic FH germline variant. Five (16%) were negative for germline FH mutations; all had biallelic somatic FH loss. Somatic NGS (31/32 patients) revealed co-occurring NF2 mutation most frequently (n = 5). Compared with clear-cell RCC, FH-RCC had a lower mutation count (median 2 vs. 4; P < 0.001) but higher fraction of genome altered (18.7% vs. 10.3%; P = 0.001). A total of 26 patients were evaluable for response to systemic therapy: mTOR/VEGF combination (n = 18, ORR 44%), VEGF monotherapy (n = 15, ORR 20%), checkpoint inhibitor therapy (n = 8, ORR 0%), and mTOR monotherapy (n = 4, ORR 0%). No complete responses were seen. Median overall and progression-free survival were 21.9 months [95% confidence interval (CI): 14.3–33.8] and 8.7 months (95% CI: 4.8–12.3), respectively.

Conclusions:

Although most FH-RCC tumors are due to germline FH alterations, a significant portion result from biallelic somatic FH loss. Both somatic and germline FH-RCC have similar molecular characteristics, with NF2 mutations, low tumor mutational burden, and high fraction of genome altered. Although immunotherapy alone produced no objective responses, combination mTOR/VEGF therapy showed encouraging results.
A Teoria do Agir Comunicativo de Jürgen Habermas: bases conceituais
Authors:   Universidade de São Paulo. Escola de Artes, Ciências e Humanidades, Bettine Marco
Published: March 2021

Este livro busca trilhar os tortuosos caminhos que Jürgen Habermas escolheu na Teoria da Ação Comunicativa (TAC) para construir o conceito de ação comunicativa. Jürgen Habermas é um pensador alemão e um dos mais influentes pesquisadores das ciências sociais do século XX. As duas grandes categorias habermasianas são: esfera pública e ação comunicativa. Suas grandes obras foram publicadas na segunda metade do século XX e marcam até hoje sua trajetória política, acadêmica e intelectual. A TAC se preocupa em apresentar os elementos teóricos fundantes da categoria denominada ação comunicativa. O longo caminho teórico percorrido por Habermas tem como interesse compreender que a busca pelo entendimento é universal, e os sujeitos, em suas ações cotidianas, têm por base o conceito de ação comunicativa. Essa forma de comunicação ocorre em um mundo da vida, onde as pessoas se entendem tanto em relação à estrutura quanto aos significados da fala.
Reading Milton through a Feminist Jungian Lens
Authors: Dib Roula-Maria
Published: March 2021

My article re-reads John Milton’s Paradise Lost through a feminist post-Jungian perspective; the study will observe the implications of contemporary Jungian critical approaches toward Milton’s portrayal of Eve, who helps Adam find ‘a paradise within …, happier far’ (PL 12. 587). I will first highlight the negative portrayal of an evil, intellectually inferior Eve in Paradise Lost, and ultimately re-reading the poem—and the role of Eve in it—from the perspective of a feminist Jung. The initial reading of Paradise Lost, in which Eve was regarded as inferior and complementary to Adam, reflects Jung’s criticized notion that the anima’s role is to complement a man’s psychology. This, however, can be read differently through a post-Jungian feminist perspective. From this new viewpoint, Eve can be regarded as Adam’s equal, rather than an inferior company, and a catalyst in their ‘coniunctio’, in which they both individuate (rather than Eve, the anima be subservient to Adam’s individuation) in Paradise Lost. Despite the vast differences between John Milton’s and Carl Jung’s cultural and historical backgrounds, this novel reading of Paradise Lost in context of revisions to Jung’s anima theory and theory of individuation offers a more positive view on the poet’s depiction of Eve in keeping with more recent developments in Milton scholarship, which have drawn attention to the way the text questions conventions of gender hierarchy and patriarchy.
Two new species of Cephennomicrus in the Ryūkyū Archipelago (Coleoptera, Staphylinidae, Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: March 2021

Ten species of Cephennomicrus are currently known to occur in Japan, predominantly in the Ryūkyū Archipelago. These extremely small beetles (adults of Japanese species do not exceed 1.2 mm) are rarely collected, and their true diversity may be in fact much greater. Two more species are described in the present study: C. aji sp. n. inhabiting Okinawa island, and C. ushimanus sp. n. found on Amami Ôshima island. Cephennomicrus aji has the smallest adults of all Japanese Scydmaeninae; the holotype male measures merely 0.66 mm of body length. The distribution of Japanese Cephennomicrus species is summarized, with the aedeagus of each species illustrated on the distribution map, to facilitate identifications and further study on this broadly distributed but poorly known cephenniine genus.
Molecular Mechanism of Bushen Jianpi Inhibition of Postoperative Recurrence and Metastasis of Hepatocellular Carcinoma
Authors: Zhou Zhangjie , Fu Shujuan , Li Yun , Que Zujun , Liu Xinhua , Yu Guanzhen , Gao Dongmei , Zhang Zhihui , Wu Tingting , Zhong Yi
Published: March 2021

Compared with western medicine, traditional Chinese medicine can better regulate the internal environment and inhibit liver cancer recurrence and metastasis. Bushen Jianpi Recipe (BSJPR) is a traditional Chinese medicine for tonifying the kidney and invigorating the spleen. It has also
been used to treat tumors and other related diseases. Here we explore the efficacy of BSJPR inhibition of hepatocellular carcinoma (HCC) in vivo and in vitro . We hypothesize that BSJPR reduces intrahepatic cholestasis and inflammation and increases expression of the bile acid receptor and
downstream targets. This study aims to test this hypothesis and determine whether the inhibitory effect of BSJPR on liver cancer recurrence and metastasis is related to bile acid metabolism. We also observed changes in immune cell expression, suggesting that regulation of the immune microenvironment
could inhibit the recurrence and metastasis of HCC. These findings provide a basis for the treatment of HCC and new ideas for follow-up studies of BSJPR.
Slicing, Tokenization, and Encryption Based Combinational Approach to Protect Data-at-Rest in Cloud Using TF-Sec Model
Authors: Keerthana N. , Vinod Viji , Sengan Sudhakar
Published: March 2021

Data in the Cloud, which applies to data as a cloud service provider (CSP), transmits stores, or manages it. The company will enforce the same definition of data usage while the data is resident within the enterprise and thus extend the required cryptographic security criteria to data
collected, exchanged, or handled by CSP. The CSP Service Level Agreements cannot override the cryptographic access measures. When the data is transferred securely to CSP, it can be securely collected, distributed, and interpreted. Data at the rest position applies to data as it is processed
internally in organized and in the unstructured ways like databases and file cabinets. The Data at the Rest example includes the use of cryptography for preserving the integrity of valuable data when processed. For cloud services, computing takes multiple forms from recording units, repositories,
and many unstructured items. This paper presents a secure model for Data at rest. The TF-Sec model suggested is planned for use with Slicing, Tokenization, and Encryption. The model encrypts the given cloud data using AES 256 encryption, and then the encrypted block is sliced into the chunks
of data fragments using HD-Slicer. Then it applies tokenization algorithm TKNZ to each chunk of data, applies erasure coding technique to tokens, applies the data dispersion technique to scramble encrypted data fragments, and allocates to storage nodes of the multiple CSP. In taking the above
steps, this study aims to resolve the cloud security problems found and to guarantee the confidentiality of their data to cloud users due to encryption of data fragments would be of little benefit to a CSP.
Internet of Thing Based Smart Traffic Control Signal Using Solar Energy
Authors: Kalpana V. , Shanthi S. , Britto A. Sagai Francis , Prakash N. B.
Published: March 2021

Nowadays traffic congestion is major problem in all over the cities. The cities are renovated to “smart cities” by using Information and Communication Technologies (ICT). The IoT are playing a vital role in smart cities. This work proposes Internet of Thing (IoT) based smart
traffic control signal using solar energy for smart cities. This signal is always coordinated with the emergency vehicle like ambulance to discover the signal and select the route where road traffic is dynamically controlled and the traffic violation vehicles are identified by traffic monitoring
officers through internet. The traffic control signal lights are automatically controlled by Raspberry Pi controller with the help of IR sensor and RF signal. If any emergency vehicle will come nearby traffic control signal then the green signal shows for emergency vehicle and the remaining
paths are shows as red signal.