bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of immobilization platforms for amine transaminases
Authors: Καλούδης Νικόλαος
Published: January 2025

Η παρούσα διδακτορική διατριβή διερευνά την ακινητοποίηση των αμινοτρανσαμινασών (ATAs) σε διάφορες πλατφόρμες, με στόχο τη χρήση τους σε χημειοενζυμικές αλληλουχίες για την παραγωγή χειρόμορφων αμινών, που είναι απαραίτητες στη φαρμακευτική και σε χημικά υψηλής αξίας. Η μελέτη χωρίστηκε σε τρεις κύριους τομείς: την οξειδωτική σύνθεση της ακετοφαινόνης από φθηνές πρώτες ύλες (αντίστοιχο αλκύνιο, αλκοόλη ή αλκάνιο), τη δοκιμή στρατηγικών ακινητοποίησης για τις ATAs και την ενσωμάτωση των αντιδράσεων οξείδωσης με τις αντιδράσειςτρανσαμίνωσης.Το στάδιο της οξείδωσης, που χρησιμοποίησε οξείδιο γραφίτη (GO) ως καταλύτη, παρουσίασε χαμηλή απόδοση, με χαμηλότερες από τις αναμενόμενες μετατροπές, οδηγώντας στη διερεύνηση εναλλακτικών μεθόδων για αυτό τον σκοπό, όπως η φωτοκατάλυση και η ενζυμική οξείδωση. Ωστόσο, οι στρατηγικές ακινητοποίησης προσέφεραν πολύτιμες πληροφορίες σχετικά με τη σταθεροποίηση και την επαναχρησιμοποίηση των ενζύμων. Το βασικό υλικό που χρησιμοποιήθηκε για την ακινητοποίηση (GO) δοκιμάστηκε αρχικά για την επίδρασή του σε διάφορα χαρακτηριστικά των χρησιμοποιούμενων ενζύμων, όπως η ειδική δραστικότητα, η λειτουργική σταθερότητα και τα δομικά χαρακτηριστικά. Η ακινητοποίηση στο GO συνοδεύτηκε από αρκετές προκλήσεις και εμπορικοί φορείς εισήχθησαν επίσης στη μελέτη για συγκριτικούς λόγους. Η ακινητοποίηση στο GO βελτίωσε τη θερμική σταθερότητα, με το πρότυπο ένζυμο να διατηρεί έως και 85% της δραστικότητάς του μετά από έκθεση σε υψηλές θερμοκρασίες (60°C για 1 ώρα). Οι βέλτιστες συνθήκες επέτρεψαν τη ασύμμετρη σύνθεση χειρόμορφων αμινών, όπως η (S)-1 φαινυλαιθυλαμίνη, με >99% ενζυμική εκλεκτικότητα, αν και οι μετατροπές ήταν κάτω από τις βιομηχανικές απαιτήσεις. Παράλληλα με τις τρανσαμινάσες, αναγωγικές αμινάσες (RedAms) δοκιμάστηκαν σε διάφορες διεργασίες για τη διερεύνηση της συνθετικής πορείας με διαφορετική κατηγορία ενζύμων. Τέλος, ο συνδυασμός αντιδράσεων οξείδωσης και αμίνωσης στο προτεινόμενο πλαίσιο αλληλουχίας δεν ήταν επιτυχής, υποδεικνύοντας την ανάγκη για περαιτέρω βελτιστοποίηση και διερεύνηση επιπλέον παραμέτρων της συνολικής διαδικασίας.
Investigation of the effect of ball heading in football, on knee neuromuscular control and predispose to injury
Authors: Κακαβάς Γεώργιος
Published: January 2025

Το ποδόσφαιρο, το πιο δημοφιλές άθλημα παγκοσμίως, μπορεί να ευθύνεται για το κυρίαρχο μερίδιο των έκθεση σε αθλήματα, όπου η υπερβολική χρηση κεφαλιας (πάνω από 1.000 ετησίως) μπορεί να είναι αιτία υποκλινική διασεισης. Το ιστορικό των αναγνωρισμένων διάσεισης δεν εξήγησε αυτές τις επιπτώσεις. Πλέονμελέτες για τραυματισμό στο κεφάλι σε άλλα αθλήματα έχουν επικεντρωθεί σε μεμονωμένα ή επαναλαμβανόμενα επεισόδια διάσεισηςσόδες, που είναι πλέον γνωστό ότι προκαλούν εγκεφαλική δυσλειτουργία, ειδικά σε ευαίσθητα άτομα. Πρόσφατα, τοπροτάθηκε ότι οι τραυματισμοί που σχετίζονται με σύγκρουση, χωρίς κεφαλιά, εξηγούν τις επίμονες επιδράσεις του ΚΝΣ απόποδόσφαιρο στους εφήβους. Ωστόσο, επειδή ο τίτλος δεν αξιολογήθηκε σε αυτή τη μελέτη, ήταν απαγορευτικόμπορεί να αναλύσει την απόδοση σε ακούσιες έναντι εκούσιες κρούσεις κεφαλής ή εκθέσεις που επίσης συμβαίνουνκατά τη διάρκεια της πρακτικής.Τραυματισμοί γονάτων χωρίς επαφή στο ποδόσφαιρο συμβαίνουν συχνά κατά την ντρίμπλα, το κόψιμο ή τη γρήγορη κατεύθυνσηαλλάζει, ενώ οι τραυματισμοί επαφής προκαλούνται από υπερέκταση του γόνατος ή μια στροφικη κίνηση. Για αυτάλόγους, η εμβιομηχανική της κίνησης της άρθρωσης του γόνατος κατά τη διάρκεια δραστηριοτήτων όπως η προσγείωση, το τρέξιμο καιΟι ελιγμοί έχουν εξεταστεί εκτενώς στο ποδόσφαιρο. Η ελλειψη νευρομυικου ελεγχου στο γόνατο που δεν μπορούν να υποστηριχθει από οστικές δομές και μύες, οδηγώντας έτσι σεσημαντικά φορτία των συνδέσμων. Ωστόσο, αναγνωρίζεται όλο και περισσότερο ότι η ακραία φόρτιση στο γόνατοτο ρισκο τραυματισμου μπορεί να ενισχυθούν μέσω μη φυσιολογικού νευρομυϊκού ελέγχου Υποθέσεις που σχετίζονται με διαφορές φύλου,και ανατομικες διαφορες στο εγκάρσιο και μετωπιαίο επίπεδο στροφής του ισχίουεχουν διαμορφωθεί και ο πρηνισμός του ακρου ποδιού. Ωστόσο, τα δεδομένα υποστηρίζουν αυτές τις θεωρίεςθα μπορούσε να είναι πιο λεπτομερής. Κατά μέσο όρο, κατά τη διάρκεια ενός αγώνα ποδοσφαίρου 90 λεπτών, ένας παίκτης έχει 51 μπάλεςτακτ, 26 με το πόδι. Σε μια πρόσφατη μελέτη, τα λακτίσματα ποδοσφαίρου αντιπροσώπευαν περίπου το 51% των δυνατοτήτωναθροιστικές ενέργειες που μπορεί να οδηγήσουν σε τραυματισμό από 18.000 ενέργειες σε 10 αγώνες ποδοσφαίρου.
Η εκπαίδευση στην μετεμφυλιακή Ελλάδα
Authors: Μεταξούδης Ελευθέριος
Published: January 2025

Η διατριβή αυτή αποτυπώνει τις βασικές διαστάσεις υλοποίησης εκπαιδευτικής πολιτικής τη δεκαετία του ’50, διερευνά τους τρόπους με τους οποίους οι ιθύνοντες τη διαχειρίστηκαν και την άσκησαν και περιγράφει τις διεργασίες της επιμόρφωσης των εκπαιδευτικών τη χρονική εκείνη περίοδο. Η προβληματική που προκύπτει και διατυπώνεται αφορά ακόμη στη διερεύνηση του τρόπου διαχείρισης των κοινωνικών, πολιτικών και οικονομικών επιπτώσεων των εκπαιδευτικών αυτών εφαρμογών, οι οποίες με τη σειρά τους έδωσαν τη δυνατότητα, ή όχι, σε διαφορετικές πληθυσμιακές ομάδες (π.χ. εκπαιδευτικούς) να εργασθούν και να εξελιχθούν. Στο πλαίσιο της εργασίας αυτής αναδεικνύονται όλες οι πρακτικές άσκησης εκπαιδευτικής πολιτικής , εκπαιδευτικών μεταρρυθμίσεων και του τρόπου δράσης ομάδας συμφερόντων, στην προσπάθειά τους να επηρεάσουν και να συνδιαμορφώσουν αυτές τις πρακτικές εκπαιδευτικής πολιτικής στη διάρκεια της ιστορικής διαδρομής τη δεκαετία του 1950 στην Ελλάδα. Η αξιολόγηση του λόγου και των δράσεων των ομάδων συμφερόντων θα γίνει με αναφορά στο πολιτικό- ιδεολογικό και κοινωνικοοικονομικό συγκείμενο της εποχής. Για την περιγραφή και την ανάλυση των εκπαιδευτικών πρακτικών και μεταρρυθμίσεων χρησιμοποιήθηκε η μέθοδος της ποιοτικής ανάλυσης περιεχομένου. Όπως προέκυψε από την ανάλυση των δεδομένων της έρευνας, στο πλαίσιο του κορπορατιστικού συστήματος διαμεσολάβησης συμφερόντων στη μεταπολεμική Ελλάδα, οι εκάστοτε κυβερνήσεις νομοθετούσαν ανεξάρτητα από τις πιέσεις ή τις θέσεις που πολλές άλλες ομάδες συμφερόντων πρότειναν. Επιπρόσθετα, η μελέτη αυτή διεισδύει στην κοινωνική ιστορία της διδασκαλίας και του διδασκαλικού επαγγέλματος στη μεταπολεμική Ελλάδα. Προφορικές μαρτυρίες, γραπτά τεκμήρια και αρχειακό υλικό σχολείων και Παιδαγωγικών Ακαδημιών φωτίζουν τις παιδαγωγικές αφετηρίες, τους καθημερινούς ρυθμούς εργασίας των δασκάλων και των διδασκαλισσών, τις διδακτικές στρατηγικές, τις εκπαιδευτικές πρακτικές, αλλά και τις αγωνίες και τις πιέσεις που υφίσταντο στο εργασιακό περιβάλλον.Τα εργαλεία της προφορικής ιστορίας της εκπαίδευσης και της αρχειακής έρευνας βοηθούν στην ανάδειξη της κουλτούρας των αιθουσών του παρελθόντος και στην ανασύνθεση της επαγγελματικής δράσης της συγκεκριμένης ομάδας επαγγελματιών. Η έρευνα, λοιπόν, ανασυνθέτει τη φωνή των δασκάλων του παρελθόντος, αναδεικνύει εκπαιδευτικά και κοινωνικά ήθη και ρίχνει φως στο «μαύρο κουτί» της σχολικής τάξης.
O λαϊκισμός ως ιδεολογία: σχέσεις και σκέψεις
Authors: Μαυρίδης Ηρακλής
Published: January 2025

Η εργασία αυτή είναι μια πρώτη προσέγγιση στο σύνθετο ζήτημα των σχέσεων μεταξύ λαϊκισμού και ιδεολογίας μέσα από δύο συγκεκριμένες εννοήσεις της ιδεολογίας. Συγκεκριμένα, συζητάμε μια σειρά από ιδέες που αφορούν εννοιακά προβλήματα αλλά και λειτουργίες της ιδεολογίας μέσα στο κοινωνικο-πολιτικό πεδίο και διαπιστώνουμε ότι υπάρχουν  ομοιότητες και αντιστοιχίες μεταξύ των δύο μορφών του λόγου, προτείνουμε δε, συμβατικά, ότι ο λαϊκισμός μπορεί να θεωρηθεί μορφή του ιδεολογικού λόγου, ίσως όχι με την έννοια της «σκληρής» πολιτικής ιδεολογίας αλλά με την έννοια μιας «λεπτής» ιδεολογίας.
Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial.
Authors: Frizelle Pauline , O'Shea Aoife , Murphy Aileen , Dahly Darren , McKean Cristina
Published: January 2025

Background In areas of social disadvantage up to 40–50% of children enter preschool with speech and language skills significantly poorer than would be expected for their age. The Happy Talk trial tests if a community embedded, targeted selective speech and language programme that simultaneously engages with parents and early childhood educators, (1) improves language outcomes in children aged between 2 years 10 months and 6 years and (2) is cost effective for the health care system. Method The Happy Talk trial is a large scale cluster randomised trial of a 12-week manualised intervention delivered in pre/school settings serving socially disadvantaged communities, in Ireland. Seventy-two clusters will receive the intervention (12 participants per cluster). Parents and pre/school staff engage in group training and coaching in the form of 12 1-hour sessions for parents and four staff workshops, over the course of the pre/school year. Training/coaching includes core interaction skills (modelling, expanding, balancing questions and comments), early literacy and phonological awareness. Blinded assessments pre- and immediately post-intervention and at 6 months follow up, will measure the primary outcomes of children’s receptive and expressive language and functional impact, and secondary outcomes of quality of life. Parental responsiveness and educator-child interactions will also be evaluated. Discussion This robust study evaluates a public health approach to the delivery of speech language and communication intervention in the ‘real world’ in the community, which focuses on prevention and equity of access. Pilot work indicates that the programme is feasible, acceptable to parents and staff, cost effective, and suitable for implementation at scale. The trial includes a process evaluation, a well-developed economic evaluation and the outcomes are directly relevant to children, families and educators. This work has the potential to improve the long-term outcomes and life chances of people living in social disadvantage. Trial registration clinicaltrials.gov NCT06460090 Trial Management There is a formal governance structure to oversee the conduct and running of the trial, consisting of a trial management group and a steering committee. More details on the composition, roles and responsibilities of each committee can be found in the supplemental material.
Common European Values and the Future of the European Union
Authors: Ciechański Jerzy
Published: January 2025

At its inception in 1957, the European integration project, now known as the European Union, was based on a set of pragmatic values and imbued with a common judeochristian heritage which, at that time, was as obvious as today it is nonexistent. Secularization, absorption of culturally distinct massive immigration, together with the elite “culture of repudiation” of Western history, tradition and values, have resulted in cultural divisions within and among EU Member States. Consequently, today the meaning of human dignity, democracy, equality, the rule of law, and respect for human rights differs depending on what side of that divide one is on. The 2004 accession to the EU of Central European Member States with their distinct national, social and cultural characteristics, exacerbated those value divisions even more. Meanwhile, the EU institutions and core Member States have been bent on imposing their version of those values upon divided societies and Member States. That does not bode well for the future of European Union as an exercise in international integration. Such conclusion is supported by Karl W. Deutsch’s seminal 1957 examination of past historical experience in that regard.
Desafíos del branding en la tercera aproximación del marketing: un enfoque bottom-up.
Authors: Goldsack-Trebilcock Sebastián , Leroux Sebastien
Published: January 2025

Los modelos de construcción de marcas han evolucionado a medida que las teorías del marketing se han desarrollado,
incorporando nuevas variables. Inicialmente, el foco se centraba en la recordación de marca, pero actualmente se ha ampliado
la perspectiva hacia el rol social que las marcas deben cumplir. Este cambio reconoce tres principales aproximaciones.
En primer lugar, la relación de control que las empresas creían tener sobre la marca se basaba en una lógica impositiva,
conocida como top-down. Sin embargo, con el tiempo, este enfoque ha dado paso a un modelo de co-creación desde un
contexto sociocultural, denominado bottom-up. En este ensayo se analizan las características y variables clave de cada
etapa. Finalmente, se examinan los desafíos estratégicos que implica este cambio en los procesos y modelos de construcción de marca, donde las dinámicas tradicionales de control se ven alteradas y las marcas deben adaptarse a un entorno más participativo y colaborativo.
Smartwatches and measurement of physical activity, sedentary behavior, and sleep: a scoping review
Authors: Silva José Francisco da , Germano-Soares Antonio Henrique , Silva Luis Carlos Barbosa , Filho Valter Cordeiro Barbosa , Oliveira Tuillamys Virgínio de , Silva Thiago Coelho de Aguiar , Tassitano Rafael Miranda
Published: January 2025

Introduction: The use of accelerometers to measure physical activity (PA), sedentary behavior (SB), and sleep has significantly impacted public health, though limitations such as storage capacity and cost persist. Smartwatches have emerged as promising alternatives, providing objective measurements and real-time data extraction. Despite their growing popularity, there is still a lack of comprehensive information on smartwatch models, sensors, and data transfer methods. Objective: To map the technical characteristics related to sensors, metrics and type of data transfer of different models of smartwatches capable of measuring PA, SB and sleep. Methods: The review utilized the Joanna Briggs Institute guidelines and included 143 smartwatch models from 12 manufacturers. Results: All models measured PA, step counts, and daily calories, while the SB metric was present in 35.5% of the smartwatches, sleep duration in 93.1%, and 35.5% of smartwatches measured PA, SB and sleep simultaneously. The most common smartwatches sensors were photoplethysmography, geolocation and gyroscope. All models were found to have Bluetooth connectivity, with 55% of the models featuring Wi-Fi connectivity, and only 11.3% of smartwatches having a mobile network. Conclusion: This scoping review can guide studies, interventions, and healthcare professionals, as well as assist end-users to select an appropriate smartwatch for measure PA, SB, and sleep.Scoping review registration: https://osf.io/3s9x5
Secondary Market Monetization and Willingness to Share Personal Data
Authors: Wu Joy
Published: January 2025

People are often unaware that their personal data can serve as valuable inputs for economic activities in secondary data markets. However, whether secondary monetization of personal data determines privacy preferences remains unclear. I examine whether privacy decisions are motivated by the data recipient’s ability to benefit from trading individuals’ data with a third party. A large online laboratory experiment involving personally identifiable psychometric data is implemented with real data-sharing consequences and monetary benefits. I find that individuals decrease their willingness to share data—both in terms of their likelihood of participating in the data market and the prices demanded for such participation—when the recipient’s ability to monetize the data through secondary trade is salient. Strategic responses to updated beliefs about the recipient’s gain from the trade are ruled out via the chosen price elicitation. I find that increased data exposure (to more recipients) does not explain the significant revealed disutility from secondary monetization. These findings are also robust to controlling for the risk exposure differences between data recipients and third parties.

This paper was accepted by Anindya Ghose, information systems.

Funding: This project was funded in part by the Institute for the Social Sciences, Cornell University.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03423 .
Identitas Perempuan Melalui Budaya Pernikahan: Kajian Feminisme Eksistensialis Beauvoir dalam Cerpen Ganti Lapik
Authors: Aprianto Hendra
Published: January 2025

This article examines women's identity in marriage culture through the short story Ganti Lapik (GL) by A.A. Navis—an analytical framework using Simone de Beauvoir's existentialist feminism approach. Through analyzing the narratives in literary works, this article explores how cultural norms and women's roles make the other or shape women's identities. The study limit in this research is only on a female character named Dahniar. The stages of this research use qualitative descriptive methods with reading and note-taking techniques. The result of reading and analyzing the work obtained from this research is that Dahniar's character shows a strong woman and a fighter. Dahniar became her person while living in the city. The events that Dahniar went through to reach the peak of her freedom and independent life went through a long process in the social community. Through reading and studying GL's short stories, it can provide an understanding of the struggle of a woman who struggles independently. Literary representations of cultural and women's issues are a treasure that sparks discussion among the general public. This article invites readers to interpret Beauvoir's thoughts in literary works as a means to raise awareness of feminist issues.
Facing Loss: Julie's Inner Struggle in Dustin Thao Novel’s You've Reached Sam
Authors: Ristan Ghaisani Fakhrani
Published: January 2025

The inner conflict experienced by the character Julie in the novel You've Reached Sam by Dustin Thao and the way Julie's character overcomes inner conflict is interesting to study with the theory proposed by Kurt Lewin.This study aims to examine the inner conflict experienced by the main character in the novel You've reached Sam by Dustin Thao, along with the factors that affect the occurrence of these conflicts using a literary psychology approach. This research is a qualitative descriptive research with primary sources in the form of phrases, words, or sentences quoted in the novel You've reached Sam and secondary sources are used in the form of reference books, and national and international journal articles. The data collection technique is carried out by reading and recording data in the form of inner conflicts and the factors that affect them. The analysis technique in this study refers to the three stages of the triangulation technique. This research found that Juliet's character experiences an inner conflict that is in accordance with Kurt Lewin's formula are approach-approach conflict; avoidance-avoidance conflict; and approach-avoidance conflict. The dominant factors that affect the occurrence of inner conflicts are  psychological pressure (driving forces) and tensions.
The Role of Digital Literacy in Social Media
Authors: Isnaini Isnaini , Nasyiriyah Tiflatun Nasyiriyah , Aulia Istighfari Novita , Rohmah Susilatur Rohmah
Published: January 2025

The increasing spread of false information (hoaxes) in the post-truth era highlights the urgent need to enhance digital literacy. Digital literacy aims to empower audiences to critically interpret the vast array of messages circulating in digital media. This study explores the significance of digital literacy, its impact, and strategies for improving digital literacy skills to combat hoaxes. This research employs a library research method with a descriptive qualitative approach, analyzing a variety of relevant literature, including journals, books, and reports. The study focuses on the evolving media ecology and introduces novel insights into digital literacy, particularly in the Indonesian context. Findings reveal that the low level of digital literacy in Indonesia evidenced by a limited ability to critically analyze information contributes significantly to the widespread dissemination of hoaxes via social media. The study identifies five essential components of digital literacy: technical proficiency, critical thinking, visual literacy, social awareness, and adaptive skills. These components play a crucial role in enabling users to detect fake news, verify information, and minimize misinformation. Moreover, the research highlights the role of digital literacy as a sustainable solution for reducing hoaxes by fostering self-regulation and informed behavior. Recommendations include integrating digital literacy into educational curricula, conducting public awareness campaigns, and encouraging collaborative efforts between government and technology platforms. By addressing these challenges, this study contributes to a deeper understanding of digital literacy as a vital tool for navigating the complexities of the digital age and fostering a more informed society.
Drunk in Shechem: Confused Language in Judges 9:28–29 as a Literary Depiction of Inebriated Speech
Authors: Hurlbert Brandon M. , Kirk Alexander T.
Published: January 2025

Abstract: In this article, we argue that Gaal's confused language in Judg 9:28–29 is best understood as a literary representation of drunken speech. Scholars have long noted various slips in sense and syntax in these verses, but text-critical solutions do not account for the data. Instead, we suggest an alternate explanation that builds on sociolinguistic research and takes into account the setting of the speech at a vintage festival. Our analysis contributes to the exegesis of Judges 9 and offers the first example we know of where stylized speech is used to make a character sound drunk in the Hebrew Bible.
Wisdom as an Answer to the Retribution Problem in Jeremiah
Authors: Frish Rachel
Published: January 2025

Abstract: In this study, I suggest that the sayings in Jer 17:5‒8, 9‒10, and 11, usually regarded as independent fragments alien to their context, form a redacted unit that serves an important role in Jeremiah 11‒20. Using a common scribal technique, all three passages quote wisdom texts that are reworked to fit their new context. These quotations serve as a source of authority to reestablish the validity of the retribution theory, in the face of specific challenges that arise in Jeremiah in general, and in the personal laments in particular. The extensive phraseological links between the unit and the personal laments, as well as its strategic location at the center of the cycle, evince an intentional and sophisticated literary structure. These findings shed new light on the exceptional character of the use of wisdom in this unit and open new directions in the study of the redaction history of Jeremiah 11‒20.
Propagation characteristics of the high-power partially-polarized partially-coherent beam in the atmosphere
Authors: Wang Zhiqiang , Wang Yingjian , Lu Lu
Published: January 2025

In this work, the formulas of critical power and self-focusing length of a partially-polarized partially-coherent beam are derived. Due to simultaneous consideration of the polarization and coherence features, it plays a beneficial role in avoiding air breakdown and prolonging the propagation distance compared with the Gaussian beam. Particularly, the analytical expressions of the essential physical quantities are obtained, including the phase, beam width, effective coherence length, intensity, degree of polarization, and degree of coherence, and these nonlinear propagation characteristics are numerically analyzed: the first five physical quantities vary periodically with propagation distance, indicating that this kind of laser beam can maintain a stable and high-power propagation in the atmosphere; meanwhile, degree of coherence indicates the existence of self-healing capability during the propagation process. These findings may have potential applications in energy conveyance, space debris removal, high-power, long-range propagation, and related fields.
Electrically dynamic terahertz phase modulator with high transmittance based on a Huygens’ metasurface
Authors: Ran Jia , Xiong Wang , Li Tianchang , Tan Fei , Zhao Shiwei , Huang Xin , Okimura Kunio , Xue Chunhua
Published: January 2025

The phase shifts of dynamic terahertz (THz) phase modulators based on transmissive metasurfaces are usually limited to within 180∘, which is a necessary amount to perform efficient terahertz wavefront modulation. Few works exhibit a phase shift larger than 200∘ but with a transmittance less than 3% during modulation. To address this challenge, a dynamic terahertz phase modulator using a dislocation-introduced dual-layer Huygens’ metasurface (HM) with embedded vanadium dioxide (VO2) is proposed. This compact design uniquely combines high transmittance with a large phase shift in broadband. Key achievements include a maximum dynamic phase shift of 281∘ at 0.64 THz with a transmittance greater than 50% both before and after a current stimulus. An operational bandwidth where the co-polarization phase shift exceeds 180∘ is 32.3% under normal incidence. And the bandwidth where the phase shift is larger than 180∘ and transmittance higher than 50% simultaneously achieves 10.4% from 0.64 THz to 0.71 THz. This innovative dual-layer HM approach efficiently balances the performance of dynamic terahertz phase modulators, opening new possibilities for dynamic terahertz wavefront manipulation devices and providing technical support for terahertz spatial light modulators and terahertz holographic projectors.
CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth
Authors: Griffith Gina L. , Machmach Kawthar , Jian Ningbo , Kim Dohoon , Costanzo Margaret C. , Creegan Matthew , Swafford Isabella , Kundu Gautam , Yum Lauren , Bolton Jessica S. , Smith Lauren , Slike Bonnie M. , Bergmann-Leitner Elke S. , Thomas Rasmi , Michael Nelson L. , Ake Julie A. , Eller Leigh Anne , Robb Merlin L. , Townsley Samantha M. , Krebs Shelly J. , Paquin-Proulx Dominic ,   for the RV217 Study Group
Published: January 2025

New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found significant differences in γδ T cell surface marker expression in participants that developed neutralization breadth compared to those that did not. Activation of γδ T cells occurred within the first weeks of HIV acquisition and associated with viral load. Expression of CD16 on Vδ1 T cells and CD57 on Vδ2 T cells were found to be significantly higher in broad neutralizers during AHI, and associated with the development of neutralization breadth years later. In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies.
“Ánforas para la nueva sangre hispana”. La difusión del nacionalismo franquista en los programas radiofónicos de puericultura (1939-1959).
Authors: Blanco Fajardo Sergio
Published: January 2025

La radio contribuyó, a través del discurso de las emisiones femeninas, a vehiculizar la doctrina del nacionalcatolicismo entre la audiencia española. En ellas, animaban a las mujeres a recuperar el espacio doméstico y realizar desde allí las funciones sociales que le correspondían en relación a su compromiso con la nación franquista. El presente artículo pretende analizar el discurso de los programas de puericultura retransmitidos en Radio Madrid, emisora perteneciente a la Cadena SER, durante el primer franquismo (1939-1959), para dilucidar cuáles fueron las conexiones entre las mujeres, la radio y el proyecto nacionalista del Régimen.
A novel surgical technique for cranial cruciate ligament repair in dogs using autologous lateral digital extensor muscle tendon graft combined with platelet-rich plasma: A preliminary experimental study
Authors: Daradka Mousa H. , Malkawi Mays A. , Ismail Zuhair Banmi , Hammouri Hanan M. , Abu-Abeeleh Mahmoud A. , Rihani Saba
Published: January 2025

Background and Aim: Cranial cruciate ligament (CrCL) injuries are a prevalent orthopedic issue in dogs, typically managed through surgical interventions such as tibial plateau leveling osteotomy and tibial tuberosity advancement. However, these techniques have limitations, including high costs and extended recovery periods. This study introduces an innovative CrCL repair method employing an autologous lateral digital extensor muscle tendon graft and evaluates the effects of platelet-rich plasma (PRP) on tissue healing.

Materials and Methods: Twenty-four healthy, male, local-breed dogs were divided into two groups. Group A underwent the surgical procedure without PRP, while Group B received intra-articular PRP during surgery. Outcomes were evaluated through clinical assessments of lameness, post-operative complications, and histological analysis over 10, 20, 30, and 40 days.

Results: The PRP-treated group demonstrated statistically significant improvements in post-operative complication scores (p = 0.0025) and histological outcomes (p = 0.0002). However, graft maturation was unaffected by PRP treatment but improved over time (p = 0.0013). PRP-treated dogs exhibited faster recovery and enhanced tissue regeneration, with reduced inflammation and improved graft-bone attachment.

Conclusion: This novel surgical approach demonstrates significant potential for improving outcomes in CrCL repair by combining autologous tendon grafting with PRP. The technique offers reduced complications and enhanced healing, providing a promising alternative to traditional methods. Further studies are recommended to validate its efficacy in clinical settings.

Keywords: canine, cranial cruciate ligament, PRP, tendon graft, tissue healing.
CHECK LIST OF COLLEMBOLAN SPECIES REPORTED FROM INDONESIA
Authors: YOSII RIOZO
Published: January 2025

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ON SIX SPECIES OF MONOGENETIC TREMATODES, PARASITIC ON THE GILLS OF MARINE FISHES FROM THE INDIAN SEAS
Authors: UNUNNITHA R VISWANATHAN
Published: January 2025

Six species of monogenetic trematodes, collected from the gills ofmarine fishes of the south west coast of India, are described. Two newgenera, Churavera and Eyelavera have been created to accommodate the two new species Churavera macrova andÂ  Eyelavera typica. Of the remaining four species which all come under the more familiar genera Gastrocotyle and Pseudaxine, three viz., Gastrocotule kalla., Gastrocotyle kurra and Pseudaxine kurra are new species while Gastrococule indica SUBHAPRADHA,1951, is recorded for the first time from the west coast of India.
REVIEW OF PARASITIC WASP SUBFAMILY EULOPHINAE (HYMENOPTERA: EULOPHIDAE) WITH SPECIAL REFERENCE OF THE TRIBE CIRROSPILINI
Authors: Ubaidillah Rosichon
Published: January 2025

The Cirrospilini LaSalle, 2000, belongs to the Eulophinae, along withEulophini and Elasmini. This tribe consists of about 17 genera and almost 300 species, which are ectoparasitoids, mainly on Diptera, Lepidoptera and Coleoptera in semi-concealed situations. Some species may act as obligate or facultative hyperparasitoids and a few species are gall-formers. Historically, the genera included in the Cirrospilini have been placed in the Eulophinae and the Elachertinae sensu Ashmead, 1904. However, the relationships and the placement of genera into subfamilies or tribes have always been problematical. Based on the current evidence, it appears that the Cirrospilini is a monophyletic taxon and the sister-group of the Eulophini plus Elasmini. This paper summarizes the current taxonomic status and systematic background of the Cirrospilini.Key words: Hymenoptera, Chalcidoidea, Eulophidae, Eulophinae, tribe Cirrospilini, taxonomical review
Synthesis, Characterization, Toxicity Analysis and in silico Evaluation of New 1,4-Benzopyrone Analogue against Human Metapneumovirus (HMPV) and Respiratory Syncytial Virus (RSV)
Authors: Sa'ad Mohammad Auwal , Ravichandran Manickam , Fuloria Shivkanya , Subramaniyan Vetriselvan , Agrawal Pankaj , Bhardwaj Gautam , Fuloria Neeraj Kumar
Published: January 2025

The global threat posed by recent respiratory viruses necessitates the development of novel antiviral agents. This study focused on the design, synthesis, characterization and cytotoxicity evaluation of two new coumarin analogues, 4-((5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)methoxy)-2H-benzopyrone (4) and N-(4-chloro-benzylidene)-2-((2H-benzopyrone-4-yl)oxy)acetohydrazide (5). These compounds were synthesized from hydrazide derivative of benzopyrone (3) through reactions with 4-hydroxybenzoic acid and 4-chlorobenzaldehyde, respectively. Structural confirmation was achieved using IR, NMR and mass spectrometry. The cytotoxicity was assessed using the MTT assay, demonstrating significant cell viability in HEK-293 cells. Molecular docking studies were performed to evaluate the interaction of the synthesized compounds with RNA-dependent RNA polymerases of human metapneumovirus (HMPV) (PDB ID: 8FPJ) and respiratory syncytial virus (RSV) (PDB ID: 8FPI). Both compounds exhibited high docking scores, indicating strong potential for inhibiting these essential viral enzymes. These findings highlight compounds 4 and 5 as promising candidates for further development as antiviral agents targeting HMPV and RSV. Interestingly, this is the first-time investigation in which benzopyrones have been explored to exhibit significant in silico activity against HMPV. However, future studies should be focused on their preclinical evaluation to establish their therapeutic potential in HMPV treatment.
Glucose Coated Nano Fe3O4 (Glu@Fe3O4): A Potential Organocatalyst for Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines in Ethanol
Authors: Sinha Amulya , Siddiqui Arzoo , Tripathi Vaibhav , Singh Girish , Yadav Amit , Srivastava Rudraksh , Fatima Nikhat , Kumar Gautam , Bhadauria Vivek
Published: January 2025

Two novel homologous series of target moieties, pyrazolo[3,4-b]pyridine-5-carboxylate substitutes (4a-e) as well as pyrazolo[3,4-b]pyridine-5-carbonitrile substitutes (5a-g) involving heterocyclic scaffold have been synthesized and characterized using FT-IR, NMR and MS spectrometry to ascertain the molecular structure. The synthetic procedure has been carried out by a one-pot three-constituent mechanistic pathway of pyrazol-3-amine, several aromatic aldehydes as well as selected CH-active compounds under green conditions via one-pot process in the presence of glucose coated nano Fe3O4 (Glu@Fe3O4) as an organocatalyst and ethanol as an efficient solvent. This conversion is congenial with a wide heterogeneity of functional group endurance. The optimized reaction conditions, good output, incorporation of organocatalyst, no necessity for column chromatographic procedure, economical and eco-friendly solvent are the merits of this reaction protocol. An ecofriendly, harmless, diversified, excellent paramagnetic behaviour possessing catalyst (Glu@Fe3O4) was prepared and characterization was performed incorporating Fourier transform infrared spectroscopy, as well as X-ray diffraction technique. The surface of magnetic nanoparticles enveloped with glucose imparted magnificent catalytic property. The catalyst could be reprocessed and reutilized until six rounds unaccompanied by major downfall in the catalytic efficiency.
Synthesis, Characterization and Antimicrobial Evaluation of Aromatic Aldehyde Derivatives of 4-Hydrazinyl-7H-pyrrolo[2,3-d]pyrimidine
Authors: Bakhale Sunil C. , Tiwari Pushpendra
Published: January 2025

A novel series of pyrrolo[2,3-d]pyrimidine derivatives (2a-j), incorporating a biologically active hydrazone moiety, was synthesized and subjected to antibacterial evaluation. Structural elucidation of the synthesized compounds was achieved using various spectroscopic methods, including IR, 1H and 13C NMR and mass spectrometry. The compounds demonstrated antibacterial and antifungal activities, with MIC values ranging between 50 and 250 µg/mL. The most resistant strains tested were Escherichia coli (MCC 2412), Staphylococcus aureus (MCC 2408), Bacillus subtilis (MCC 2010), Pseudomonas aeruginosa (MCC 2080), Saccharomyces cerevisiae (MCC 1033) and Candida albicans (MCC 1439). All of the compounds showed significant efficacy, according to the antimicrobial screening, with several of them surpassing the common drugs fluconazole and ciprofloxacin.
DFT Studies, Structural Investigation and in vitro Biological Evaluation of Binary Metal Complexes Derived from (R)-N-Phenyl Ethylamine and 2-Hydroxy-1-naphthaldehyde
Authors: Tota Jagadish , Kasoji Eshwari , Doma Anitha Ranga Sree , Mohamad Kadeer , Dosali Mallesh
Published: January 2025

The chiral Schiff base (HL) derived from 2-hydroxy-1-naphthaldehyde and N-phenyl ethylamine and its metal complexes. Co(II), Ni(II) and Cu(II) were synthesized and characterized by the molar conductance, TGA, FT-IR, UV-visible and mass spectral techniques. Gauss-View screen was used to visualize all the synthesized compounds using Gaussian 09 software. Molecular electrostatic potentials, frontier molecular orbitals, the 6-311++G (d,p) basis set for the ligand, as well as SDD basis sets for its metal complexes, were used in the DFT/B3LYP functional analysis in order to investigate the most probable stability of the HL ligand and its complex based on EHOMO and ELUMO values. As a first step in screening for in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, the disc diffusion assay was employed, while the cytotoxicity of the synthesized compounds was assessed using the MTT assay. Cobalt(II) complex showed strong antibacterial properties against P. putida and B. subtilis strains, while Cu(II) complex showed significant antitumor activity against MCF-7 and HeLa strains.
Studies on Growth, Structural, Luminescence, Linear and Nonlinear Optical Properties of Bisthiourea Lithium Zinc Sulphate Single Crystal for Optoelectronics Applications
Authors: Punniyamoorthy R. , Joseph A. Franklin Alex , Satish A. , Chitravel M. , Vengadesan A. , Pasupathi G. , Abuthahir S.S. Syed
Published: January 2025

Bisthiourea lithium zinc sulfate (BTLZS) single crystals have remarkable nonlinear optical properties. The crystals were prepared using slow evaporation of solution growth techniques (SEST). The crystal structure and crystalline properties of the synthesized crystals was conducted with powder XRD and SCXRD techniques, respectively. The orthorhombic system of BTLZS crystal has been identified with space group Pca21. The existence of vibrational functional groups in the synthesized crystal was confirmed by FTIR spectroscopy. The optical parameters were determined through UV-Vis-NIR transmission spectra. The synthesized BTLZS demonstrated that the emission of green light at 581 nm within its photoluminescence (PL) spectra. The Kurtz and Perry powder method serves as a means to explore the nonlinear optical properties of synthetic crystals. The enhanced second harmonic generation (SHG) has 1.63 times more efficiency than standard postassium dihydrogen phosphate (KDP) crystal. The analysis on thermal and laser damage thresholds shows that this crystal demonstrates stability and holds promise for applications in optoelectronic devices.
Catalytic Synthesis of Carbon Nanotubes using CeFeMgO: Study their Efficiency and Structural Insights
Authors: Manikandan D. , Somanathan T. , Pandurangan A.
Published: January 2025

The catalytic synthesis of carbon nanotubes (CNTs) using CeFeMgO catalysts represents a promising avenue for achieving efficient and controlled carbon nanotube growth. The CeFeMgO catalysts were prepared by solution combustion techniques and the growth of CNTs was obtained from the chemical vapour deposition (CVD) method. The X-ray diffraction (XRD), high-resolution scanning electron microscopy (HR-SEM),w energy dispersive X-ray spectroscopy (EDAX), transmission electron microscopy (TEM), thermogravimetric analyzer (TGA), BET, particle size distribution. were employed to characterize the morphology, crystallinity and composition of the synthesized CNTs. Results indicate that the study reveals the robust catalytic activity that facilitates the formation of high-quality carbon nanotubes (CNTs), highlighting the efficiency of CeFeMgO catalysts in promoting CNT growth and elucidating the structural aspects crucial for optimizing carbon nanotube production. The results demonstrate uniform carbon nanotube dimensions, excellent crystallinity and minimal defects, highlighting the efficacy of catalyst in achieving controlled and efficient carbon nanotube synthesis. This study enhances the comprehension and utilization of CeFeMgO catalysts in the synthesis of carbon nanomaterials.
Effect of Ni and Cu Doping on ZnO Nanoparticles Synthesized by Solution Combustion Method: Antimicrobial Activity and Photocatalytic Degradation of Methylene Blue Dye
Authors: Valsaraj P. Vinisha , Rajan Anagha , Ashna P. , Rajan Sreshma
Published: January 2025

The green solvent solution combustion method was effectively used to synthesize Zn1-xNixO and Zn1-xCuxO nanomaterials using extract of Moringa oleifera leaves. The structural, morphological and optical properties of the produced doped nanomaterials were investigated using XRD (X-ray diffraction), SEM (scanning electron microscopy), EDX (energy-dispersive X-ray), Raman spectroscopy and UV-Vis diffuse reflectance spectroscopy. The photocatalytic efficacy of the synthesized materials was examined concerning the breakdown of methylene blue dye during UV light exposure. Zn1-xCuxO was found to be the most efficient photocatalyst among the compounds under investigation, degrading 83% of dye after 2 h of exposure to light. Further, the antibacterial activity against both Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) were evaluated through analysis of zone of inhibition. Among the prepared nanostructures, Zn1-xCuxO sample showed excellent antibacterial activity against Gram-positive bacteria. The potential photocatalytic and antibacterial activity of synthesized doped nanomaterials makes them useful for environmental remediation.
Synthesis and Evaluation of Magnesium and Zinc-Doped Hydroxyapatite-Banana Flower Extract-PLGA Composite for Bone Regeneration
Authors: Suresh Munusamy , Karthikeyan Palanisamy , Vadivel Pullar
Published: January 2025

Strategies for bone tissue regeneration need methods that provide an osteogenic environment conducive to bone formation. This study examines the synthesis and characterization of a new biocomposite material consisting of magnesium and zinc-doped hydroxyapatite (MZHAp), banana flower extract (BFE) and poly(lactic-co-glycolic acid) (PLGA) for possible applications in bone tissue engineering. The synthesized material was analyzed using FTIR, XRD, SEM-EDAX and microhardness assessments. The findings indicated effective incorporation of BFE and PLGA into the MZHAp matrix, resulting in increased crystallinity, superior mechanical characteristics and regulated shape. In vitro investigations, including cell survival, alkaline phosphatase (ALP) activity and alizarin red S (ARS) staining, demonstrated superior biocompatibility and considerable osteogenic potential of the MZHAp-BFE-PLGA composite. Moreover, the biocomposite demonstrated significant antibacterial efficacy against both Gram-positive and Gram-negative microorganisms. The results indicate that the MZHAp-BFE-PLGA composite may serve as a promising biomaterial for bone tissue regeneration applications.
Synthesis of Chromeno/Pyrano-quinolines via Tandem Approach involving Michael Addition-Cyclization Catalyzed by L-Proline/Cu(II)
Authors: Arif Md. Khaja , Rathod Praveen Kumar , Leelavathi Panaganti
Published: January 2025

In this study, the reaction of β-nitrovinylquinolines with 1,3-dicarbonyl compounds to furnish chromeno-quinolines under L-proline/Cu(II) catalysis was described. The nitro methyl derivatives of chromeno-quinolines were obtained via the Michael addition followed by the cyclization reaction of cyclic 1,3-dicarbonyl compounds with β-nitrovinylquinolines in a tandem approach. The reaction with open-chain 1,3-dicarbonyl compounds furnished the corresponding aci form of pyranoquinolines.
Prevalencia de sintomatología depresiva en niños en un hospital del Quindío Colombia.
Authors: Villa Bustamante Alejandra , Oros Vargas Laura Nataly , Olave Jaramillo Marcela
Published: January 2025

Introducción: la depresión es una enfermedad a nivel mundial, se calcula su afectación a más de 300 millones de personas independientemente de la edad, género, o estrato socioeconómico; La prevalencia de sintomatología depresiva en niños puede variar de un país a otro y depende de varios factores independientes de zona o región a evaluar, estas cifras van desde 1,4% a 11,7%.
Metodología: se evaluó la prevalencia de sintomatología depresiva en niños y adolescentes en edades entre 7 y 16 años que se encontraban hospitalizados en el servicio de pediatría del E.S.E Hospital Departamental Universitario del Quindío, San Juan de Dios, independientemente de su diagnóstico de hospitalización; por medio de un estudio de tipo transversal en el cual se realizó una encuesta sociodemográfica al acudiente y posteriormente una escala CDI (Cuestionario de Depresión Infantil) al niño participante,
Resultados: utilizando la escala CDI y tomando como base una puntuación mayor o igual 12 puntos se obtuvo positividad en el 39.1% de la población. De acuerdo con la escala CDI, algún síntoma de depresión con valores entre 12 y  18  puntos, 24.3%, siendo este el grupo de mayor prevalencia, indicando la proporción en nuestra población infantil, con sintomas leves; el grupo con puntaje mayor a  19 clasificados como síntomas depresivos moderados y severos represento un 14.8%.
Conclusión: La prevalencia de sintomatología depresiva en niños es mayor con respecto a la literatura encontrada, generando datos alarmantes para nuestro país.
Piomiositis Multifocal En Asociación A Subluxación De Cadera En Paciente Pediátrico: reporte de caso
Authors: Perez Vanegas Maria Camila , Jimenez Claros Maira , Ramos Marin Johan Sebastian , Perez Vanegas Angie Carolina , Galvis Luis Antonio
Published: January 2025

Resumen
 Antecedentes. La piomiositis es una infección aguda del músculo estriado, afecta principalmente a niños escolares y con mayor frecuencia a aquellos que residen en países tropicales. El patógeno principalmente aislado es el Staphylococcus aureus meticilino resistente (SAMR). Su diagnóstico representa un reto, dada la inespecificidad de su clínica que simula distintas patologías. Los hallazgos imagenológicos en conjunto con el aislamiento microbiológico son esenciales en el diagnóstico. Reporte de caso. A continuación, se presenta el caso de un niño de 3 años de edad con diagnóstico de subluxación de cadera en relación a una piomiositis multifocal de los músculos iliopsoas, glúteo medio, obturador externo, obturador interno y pectíneo. Se empleo un manejo conservador basado en la antibioticoterapia como pilar fundamental. Alcanzando una completa resolución del cuadro tanto clínico como imagenológico evidenciado en la RM de seguimiento. Conclusión La piomiositis es una infección común en los países del trópico, en muchos casos el cuadro clínico es inespecífico siendo una gran simuladora de otras patologías, por lo cual es frecuentemente subdiagnosticada. Los hemocultivos presentan un bajo rendimiento en la mayoría de casos, a diferencia de los cultivos tomados directamente del absceso. Siendo fundamental la sospecha diagnostica para emplear de manera oportuna el correcto cubrimiento antibiótico