bluuebunny/crossref_metadata_2025 huggingface dataset:
CREATION THE MATHEMATICAL SKILLS AMONG TECHNICAL UNIVERSITY STUDENTS FOR SUCCESSFUL DEVELOPMENT OF A GENERAL PHYSICS COURSE
Authors:   Tver State Technical University, Tver, Russia, Krivenko I. V. , Smirnova M. A. ,   Tver State Technical University, Tver, Russia, Ispiryan S. R. ,   Tver State Technical University, Tver, Russia, Ivanov G. N. ,   Tver State Technical University, Tver, Russia
Published: October 2023

The paper is devoted to the issue of mathematical knowledge of students who are beginning to study physics at a technical university. It is noted that students do not understand that the mathematical skills created at school could be applied for solving physical problems, and than be used in describing physical processes in technical and technological systems. The ways of solving this problem are proposed by transferring the beginning to study the general physics at second semester, intensive training of applicants in elective courses at school and propaedeutic courses at universities. The methods of problem-based and personality-oriented teaching at propaedeutic physics courses, which authors used at practice, as well as methods of activating the students mental activity, are analyzed.
THE ROLE OF BILINGUAL TEXTBOOKS IN TEACHING MATHEMATICS TO INTERNATIONAL STUDENTS
Authors:   Belarusian State University of Transport, Gomel, Repablic of Belarus, Kulazhenko Yu. I. , Gribovskaya E. E. ,   Belarusian State University of Transport, Gomel, Repablic of Belarus
Published: October 2023

One of the criteria for the competitiveness of the university in the market of educational services is the ability to teach foreign students, as well as the demand for educational institutions among foreign applicants. High-quality teaching of mathematics is impossible without textbooks and teaching aids. The developed bilingual manual contributes to the accessibility of education in mathematics for foreign students studying both in groups with Belarusian students and in groups consisting only of foreign students.
SOME PROBLEMS ON SECOND ORDER CURVES WITH PARAMETER
Authors:   Bauman Moscow State Technical University, Moscow, Russia, Sobolev S. K. , Tomashpolsky V. Ya. ,   Bauman Moscow State Technical University, Moscow, Russia, Golosov A. O. ,   Bauman Moscow State Technical University, Moscow, Russia
Published: October 2023

The methodological aspects of teaching the section "second-order curves" in the course of analytical geometry at a technical university are considered. The necessity of including non-standard problems in the course, in particular, tasks with parameters for deeper assimilation of educational material, is discussed. Such tasks are designed to form students' research and analytical skills. Problems on a tangent to a second-order curve are considered as problems with a parameter. A sheaf of curves intersecting at the same points is investigated as a family of lines described by a second-order equation with a parameter.
THE SPECIFICS OF BUILDING A TVIMS COURSE FOR ADVANCED TRAINING OF GRADUATES
Authors:   Plekhanov Russian University of Economics, Moscow, Russia, Sukhorukova I. V. , Chistyakova N. A. ,   Plekhanov Russian University of Economics, Moscow, Russia
Published: October 2023

The paper considers the methodology for the formation of the discipline "Mathematical Statistics" for advanced training courses, additional education courses, as well as a special course for technical, economic and other areas of study with shortened curricula for this discipline. The purpose of this work is to describe the structural organization of the educational process for a deeper study of the methods of mathematical statistics. In-depth research methods are given, methodological recommendations for their use are given, examples of the application of algorithms are considered.
Retrospective analysis of the results of systemic therapy of moderate to severe papulo-pustular acne
Authors: Khismatulina Irina M. , Faizullina Еlena V.
Published: October 2023

Background: Systemic isotretinoin is an effective treatment for acne, but the significant relapse rate requires a search for optimal daily doses to prolong disease remission.
Purpose: To compare the results of systemic therapy of moderate-to-severe resistant and severe papulopustular pustular acne with isotretinoin at daily doses of 0.5; 0.7 and 1.0 mg/kg body weight.
Methods: In a retrospective study, data from outpatient records and facial skin corneometry results of 125 individuals (95 acne patients, 30 healthy individuals) were analyzed. Patients with acne received isotretinoin (Sotret)at a daily dose of0.5; 0.7 or 1.0 mg/kg body weight, with a cumulative dose of 120 mg/kg body weight in all patients. The duration of follow-up of patients, according to outpatient records, was 18 months.
Results: Isotretinoin systemic therapy was effective in patients in all compared groups. The resolution of inflammatory elements was faster (p0.001) in those who received doses of isotretinoin 0.7 and 1.0 mg/kg body weight. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in all groups. There was a significant difference in the incidence of adverse events depending on the dose of isotretinoin. The number of patients with relapses registered at 18-week follow-up after therapy in Group I was 6 (18.75%); in Group II, 4 (12.5%); in Group III, 1 (3.2%), the differences between the groups being significant (p=0.003).
Conclusion: Therapy of moderate-to-severe resistant and severe papulopustular acne with systemic isotretinoin (Sotret) at daily doses of 0.5; 0.7 and 1.0 mg/kg at a cumulative dose of 120 mg/kg body weight demonstrates comparable clinical efficacy. However, recurrence rates during the 18-month follow-up period correlated with the daily dose of the drug.
Inhibition of tumor growth in osteosarcoma cell culture with mir162a miicroRNA
Authors: Гребнев Д.Ю. , Маклакова И.Ю. , Корнилов Д.О. , Симарзина В.М. , Тряпицын М.А. , Казанцев Ю.А. , Зорников Д.Л. , Григорьева Ю.В. , Фадеев Ф.А.
Published: October 2023

Цель исследования – изучение влияния микроРНК mir162a на жизнеспособность опухолевых клеток линии остеосаркомы SAOS-2. Методика. Исследования выполнены на клеточной линии SAOS-2. Была произведена трансфекция микроРНК mir162a в дозе 90 пмоль. Через 24, 48 и 72 ч после трансфекции методом флуоресцентной микроскопии производился подсчет жизнеспособных клеток, клеток в состоянии некроза и апоптоза, а также оценивался уровень аутофагии. Результаты. Трансфекция клеток SAOS-2 микроРНК mir162a через 24, 48, 72 ч приводила к снижению доли жизнеспособных клеток, увеличению доли клеток с признаками апоптоза и некроза по сравнению с контрольными образцами. Через 24 ч с момента трансфекции процент жизнеспособных клеток в опытных образцах был ниже чем в контрольных на 29,3%, через 48 ч – на 33,9%, через 72 ч – на 47,4%. Трансфекция SAOS-2 микроРНК mir162a приводила к четырехкратному снижению активности аутофагии. Заключение. Полученные результаты свидетельствуют о наличии у микроРНК mir162a терапевтического потенциала в качестве средства патогенетической терапии злокачественных опухолевых заболеваний.

Aim. To study the effect of mir162a microRNA on the viability of SAOS-2 osteosarcoma tumor cells. Methods. The study was performed on SAOS-2 cell culture. The mir162a microRNA was transfected at a dose of 90 pmol. At 24, 48, 72 hours, viable, apoptotic, and necrotic cells were counted by fluorescence microscopy in the transfected cell culture. Also, the level of cell autophagy was evaluated. Results. The transfection of SAOS-2 with mir162a decreased the proportion of viable cells and increased the proportion of apoptotic and necrotic cells at 24-72 hours after the procedure. Compared to the negative control, the proportion of viable cells in the mir162a-transfected SAOS-2 samples was decreased by 29.3%, 33.9%, 47.4% at 24, 48, and 72 hours, respectively. The transfection caused a 75% decrease in the autophagy level. Conclusion. The results suggest that mir162a microRNA has a therapeutic potential for the pathogenetic therapy of malignant neoplasms.
Dipinti of the I century B.C. – I century A.D. fish factory-owners from Panticapaion
Authors: Яйленко В. П.
Published: October 2023

The author has gathered together 21 dipinti on clay κάδοι (barrels), all they have originated from Panticapaion. The inscriptions include personal name – Dionysios or Onesiphoros, weight of the wares and 1‑2 additional ciphers, one is certainly price (№ 2, 4–23). A dipinto on κάδος № 1 confirms that it contains salt fish. So all these dipinti are trade marks of the fish factory‑owners. There are also many such κάδοι without inscriptions. The author dates all them from the I century B.C. or I century A.D.
New commercial inscriptions on amphorae  of the V–IV centuries BC from Phanagoria
Authors: Завойкина Н.  В.
Published: October 2023

Three inscriptions on amphorae from Phanagoria have published in the article. The inscription no. 1 was made on a Chios amphora dating to the second quarter of the Vth century BC. It reports «Πυρρίης Κλαυσει ΑΙ». The name Πυρρίης has found for the first time in the anthroponymy of the Bosporan cities. This is the Ionian form of the ancient Greek name Πυρρῖας. The letters ΚΛАΥΣΕΙ present dat. sing. of the male name Κλαυς. The name Κλαυς is incited on a black-glazed stemless pallet dating from the second quarter to the middle of the Vth century BC from Phanagoria. It is assumed that the name Κλαυς represents an early version of the Ancient Greek transliteration of the Cilician name Κλους. The abbreviation AI has been interpreted as «αἴθοψ οἶνος». An analysis of the testimonies of Ancient Greek authors has showed that the phrase hides a certain sort of red wine from Chios – seasoned dark-red wine, which the Ancient Greeks named «black wine». Thus, the inscription no. 1 reports «Pyrries to Claus some seasoned black wine». The inscription no. 2 is represented by the letter «A» scratched on the neck of a Chios amphora dated to the 3rd quarter of the VIth century BC. It is widely believed that the letter A on amphorae is an abbreviation of the phrase «ἀμπέλιος οἶνος, – grape wine». The inscription no. 3 informs «μέλαιναι Νίκωνι, – many black to Nikon» and it is written in red paint on the fragment of a Thasian amphora. It dates from the second half of the Vth - the first half of the IVth centuries BC. The analysis of the tes timonies of ancient Greek authors has revealed that adj. pl. fem. μέλαιναι refers to black olives. Traditionally, ancient Greeks ate them in crushed form. New and published dipinti and graf fiti on amphorae from Chios and Thasos from Phanagoria, have given rise for a conclusion about the regular supplies of olives from Thasos from the second half of the Vth – beginning of the IIIrd centuries BC and several sorts, mainly, red wine from Chios in the last third of the VIth – IVth centuries BC. The archaeological materials from Phanagoria have provided us with information about several sorts of the Chios wine contained in amphorae. The abbreviation «ΑΙ» is interpreted as «αἴθοψ οἶνος, – seasoned red wine»; «ΑΥ» – «αὐστηρὸς οἶνος,– dry red wine». The name «Χῖος οἶνος», hidden under the abbreviations «X», «XI» of the amphorae, apparently, should be considered as the name of a closer unknown variety of Chios wine. The name «ἀμπέλιος οἶνος, – grape wine», which was denoted by the letter «A» on amphorae, is a generalized name for wine. Such a definition may be hiding under it some apparently dry and cheap wine, brought in amphorae, including from Chios.
Inlet burials IV B.C. in the mound “Sultanovka 1” (Kerch peninsula)
Authors: Меньшиков М. Ю.
Published: October 2023

This paper discusses a group of objects discovered during the study of a natural hill located on the Kerch peninsula. In the ancient times this hill was perceived as anthropogenic. Four antique times objects were explored during the process of the rescue archaeological works: two burials, one cenotaph and one location of the funeral feast can all be dated to 4th century BC.
Aerial photogeodetic methods for identifying archaeological sites on the Iluraton Plateau and the Kytaion Plain
Authors: Пигин А. П. , Хршановский В. А.
Published: October 2023

The article summarizes preliminary results of the aerial photogeodetic method by means of unmanned aerial vehicles (UAVs) in research at the archaeological sites of the Iluraton Plateau and the Kytaia Plain. The existing topographic plans of the kurgan group and the necropoleis of the Iluraton Plateau have been verified; also, the discrepancies in the mutual arrangement of the crypts at the southwestern necropolis have been identified, the most promising areas for further research have been determined, and finally a reference network and a synoptical topographic plan of all archaeological sites known on the plateau was initiated. In order to fix and initiate the study of the mound group at the Chatre-Tav ridge of the Kytaia Plain, a topographic plan was created in accordance with a new method. The reference network and the synoptical plan of archaeological subjects of the Kytaia Plain, adjacent to the Kytaia settlement from the northeast, north, northwest and southwest, made it possible to clarify their interposition and possible interrelation. Aerial photography helped to establish that the extension of ramparts, which had been recorded earlier in the coastal zone of the southwest ern section judging by the traces on the plowed field, stretched several hundred meters to the north, probably to the southern foot of the Djurga-Oba ridge. A special survey of the ramparts closest to the western fortification wall resulted in finding out that those were terraces with a slight reverse incline (to the west), which may appear to be important for determination of their origin and functionality. Generally speaking, and judging by the results of the work, the new method of aerial photogeodetic survey has actually proved its efficiency and positive perspective for archaeological sites’ research.
Thiasos in Chersonesus of Zeno
Authors: Сапрыкин С. Ю.
Published: October 2023

The author is publishing a fragment of new Greek inscription on marble found by accident on the place of the settlement on the Cape of Zyk (the ancient Bosporan town of Chersonesus of Zeno). It is a part of a decision or decree of thiasotoi – members of voluntary association. It was adopted by the priest, the paraphilagathos and the gymnasiarchos whose names are unfortunately lost except two letters in the priest’s name Pe(….) and three letters in the gymnasiarchos’ farther’s name (…)ean(…). The latter is restored as personal male name {Th}ean(gelos)? popular among members of the Bosporan associations in Imperial period. We now have five inscriptions from Chersonesus of Zeno which belong to the associations of its citizens. Their study allowed the author to attribute all of them to one and the same thiasos which was active in course of the 2-3rd centuries AD and united the inhabitants of this town, mostly the Greeks by origin. Besides publishing the newly discovered document the author corrects the early suggested reading and interpretation of three other inscriptions from Chersonesus of Zeno. He admits that two separated pieces – one earlier attributed as the official decree or a letter of king Cotys III and dated to the time of his reign, and the second one, defined as a list of the thiasotoi, are in fact two fragments of one inscription – edict of the Zenonites’ association, ad opted in the time of Cotys III by the head of the union, presumably the synodos with the priest and probably the parahilagathos at the head. He also gives a vast commentary to other inscriptions – one mentions “the father of synodos”, and the other which is a list of thiasos’ members. He corrects the reading of one of the names in this list to be restored as (Pol)yaenos but not as Hroxenos. The association in Chersonesus of Zeno stands close to the associations of Panticapaeum and Tanais. The author made a complete study of the organization, activity, logistics and policy of the Bosporan associations towards the royal power, having admitted that synodoi could hardly be separate voluntary or alternative unions at Bosporus. They were initially sacred groups in the thiasoi but later, since the late 1 – 2nd century AD, started to function as their praesidium, i.e. head or council of associations, which included members of high position.
Data of the earliest Greek historians on the region  of the Cimmerian Bosporus
Authors: Суриков И. Е.
Published: October 2023

Herodotus and Thucydides give almost no information on the Bosporan region, but there are relevant data about it in extant fragments of even earlier Greek historians, Hecataeus of Miletus and Hellanicus of Lesbos. The article deals with these data: the fragments in question are interpreted and commented, and some historical observations are made on their material.
Fine Ware and Lamps from the Residence of Chrysaliskos
Authors: Журавлев Д.  В. , Ломтадзе Г.  А.
Published: October 2023

The Residence of Chrysaliskos is one of the most interesting Late Hellenistic fortified con structions, situated in the north-eastern part of the Taman Peninsula. It was excavated in 1970- 1973 by Nikolay Sokol’skiy. This house, which was a residence of a powerful Bosporan official during the reign of king Asandros, was destroyed in a great fire. In the layers of destruction, an important pottery assemblage was unearthed. The materials from the excavations have been preliminary published but without any special analysis of the ceramic complex. We could not distinguish exactly all the production centers of this pottery without ar chaeometric studies, but according to visual characteristics the main part of them belong to Bosporan sigillata, a local group of pottery distributed only in the Bosporan kingdom. Some Pergamene and Knidian vessels as well as their local imitations were also found here. A sepa rate group of pottery of the same shape as Bosporan sigillata was covered with black slip. Several lekythos and unguentaria are also present in the article. Lamps of jug-shape type, typical for the late Hellenistic period, are the most common group among lighting equipment. This article is the revised version of the publication in English in the volume of the Inter national Association for Research on Pottery of the Hellenistic Period (Lomtadze, Zhuravlev 2020). All the parallels for different pottery groups came from Crimea and Taman peninsula, as well as from other regions of the Black sea area and Mediterranean, mainly from the contexts of the second quarter of the 1st century BC From our point of view the Residence of Chrysaliskos could have been destroyed in the late third – early fourth quarter of the 1st century B.C., however it is still not evident what exact historic events could have caused such considerable devastation
Enhancing Imidacloprid Adsorption Capability in Sugarcane Mill Mud through Hydrothermal Activation
Authors: Brown Alexander , Garozzo Nicholas , Nawas Shahid , Baradoke Ausra , Brown Christopher , Kim Tak
Published: October 2023

The sugar industry in Australia produces a significant amount of waste, with an annual yield of four million tonnes of sugar products derived from thirty million tonnes of sugarcane. One of the notable by products is sugarcane mill mud. This work is focused on the hydrothermal activation of mill mud waste sourced from a sugar mill. The objective was to produce an economically feasible adsorbent material suitable for pesticide adsorption applications. Significant alterations were noted in the mill mud that underwent hydrothermal activation, encompassing discernible chemical and physical modifications, accompanied by altered surface properties. Comprehensive characterisations using electron microscopy and X-ray photoelectron spectroscopy studies. The hydrothermal activation process resulted in a transformation of the physical structure, shifting from agglomerated multiple layers to discrete forms characterised by single layers. The evaluation of the highest adsorption capacities for organic compounds, carried out using the methylene blue dye assay, demonstrated a significant increase at least three times after activation. It is noteworthy that the hydrothermally activated mill mud displayed a mono-layer adsorption profile, which contrasts with the untreated mill mud sample. The adsorptivity of the activated mill mud was assessed in relation to imidacloprid, a commonly used pesticide in Australian sugarcane farms. The objectives of this evaluation were to assess the efficacy of the mill mud as an adsorbent for pesticide. Evidently, the adsorption capacity exhibited equivalence to that of the reference activated carbon, surpassing the commercially available coconut activated carbon. This discovery highlights the potential of its application as a protective measure against pesticide runoff barrier in sugarcane plantation.
Pocket Crafter: A 3D Generative Modeling Based Workflow for the Rapid Generation of Hit Molecules in Drug Discovery
Authors: Shen Lingling , Fang Jian , Liu Lulu , Yang Fei , Jenkins Jeremy L. , Kutchukian Peter S. , Wang He
Published: October 2023

We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit finding activity in the drug discovery process. This workflow utilized a 3D (three-dimensional) generative modeling method, e.g. Pocket2Mol, for the de novo design of molecules in spatial perspective for the targeted protein structures, followed by filters for chemical-physical properties and drug-likeness, SAR (structure-activity relationship) analysis, and clustering to generate top virtual hit scaffolds. In our WDR5 case study, we acquired a focused set of 2029 compounds after a targeted searching within Novartis archived library based on the virtual scaffolds. Subsequently, we experimentally profiled these compounds, resulting in a novel chemical scaffold series that demonstrated activity in biochemical and biophysical assays. Pocket Crafter successfully prototyped an effective end-to-end 3D generative chemistry-based workflow for the exploration of new chemical scaffolds, which represents a promising approach in early drug discovery for the identification of novel active compounds.
Fine-Tuning Dual Single-Atom Metal Sites on Graphene Toward Enhanced ORR Activity
Authors: Xie Evan , Wang Xijun
Published: October 2023

The electrocatalytic oxygen reduction reaction (ORR) plays a crucial role in numerous energy and sustainability systems, such as fuel cells, metal-air batteries, and water electrolysers. It holds significant potential for renewable energy generation, transportation, and storage, heralding a cleaner and more sustainable future. Recent trends have shown increased use of single-atom catalysts (SACs), particularly metal-N4 moieties grown on graphene-based 2D materials, for enhancing ORR efficiency. However, the rational design of SAC for high-performance ORR faces challenges due to unclear structure-property relationships and the limits of conventional experimental trial-and-error approaches. In this study, we harnessed the power of the density functional theory (DFT) calculations, combined with cutting-edge machine learning (ML) techniques, to explore 144 SACs featuring dual interacting M1-N4 and M2-N4 moieties (M1, M2 = Mn, Fe, Co, Ni, Cu, Ru, Rh, Pd, Ag Ir, Pt, Au), denoted as M1-M2, grown on graphene. Of all the catalysts we examined, Fe-Pd emerged as the top performer, achieving an impressive overpotential of 0.211 V vs. RHE in alkaline conditions — outperforming most previously reported SACs. Even more striking, 25 of the evaluated SACs surpassed the renowned Fe-N4 SAC in catalytic efficiency, including more economically viable alternatives like Fe-Ag. Venturing further, we developed three ML models that accurately predict the overpotentials of various M1-M2 SACs, showing their strong ability to capture the relationship between single-atom metal site properties and overpotential. These models provide useful navigation toolkits for the rational design of effective electrocatalysts. Our study sheds light on the path toward achieving efficient SAC-catalyzed ORR, contributing to a more sustainable and energy-efficient future.
Confinement Synthesis of Metal Chalcogenide Quantum Dots within a Porous Organic Cage
Authors: Wilms Michael , Melendez Lesly V. , Kendall Owen , Della Gaspera Enrico , van Embden Joel , Connell Timothy U. , Gomez Daniel E
Published: October 2023

We report the first successful encapsulation of metal chalcogenide nanocrystals within the largest purely organic cage to date, comprising of twelve highly light absorbing porphyrin units. The confinement synthesis yielded nanocrystals below Bohr exciton radius of cadmium sulfide. Optical and electrochemical measurements revealed the cage ligand transfers its excited state energy to the encapsulated nanocrystal core, resulting in a 5-fold increase in photoelectrochemical water splitting efficiency compared to traditional oleic acid capped CdS nanocrystals.
Transition-metal free boron triiodide-mediated reduction of nitroarenes from simple borohydride reagents
Authors: Williams Florence , Corkovic Andrej , Chiarella Thomas
Published: October 2023

The reduction of nitroarenes using KBH4 and I2 is described. BI3 is generated in situ, which was shown to be the active reductant. Conditions were optimized for BI3 generation, and then applied to a wide range of nitroarenes, including traditionally challenging substrates. The method constitutes a practical reduction option which produces low toxicity boric acid and potassium iodide upon workup.
Discovery of Antibacterial Manganese(I) Tricarbonyl Complexes through Combinatorial Chemistry
Authors: Scaccaglia Mirco , Pelosi Giorgio , Pienlli Silvana , Frei Angelo
Published: October 2023

The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current antibiotic arsenal, they are falling short in providing new drugs with novel modes of action able to treat multidrug resistant bacteria. Metal complexes have recently shown promising results as antimicrobial agents, but the number of studied compounds is still vanishingly small, making it difficult to identify promising compound classes or elucidate structure-activity relationships. To accelerate the pace of discovery we have applied a combinatorial chemistry approach to the synthesis of metalloantibiotics. Utilizing robust Schiff-base chemistry and combining 7 picolinaldehydes with 10 aniline derivatives, and 5 axial ligands we have prepared a library of 420 novel manganese tricarbonyl complexes. All compounds were evaluated for their antibacterial properties and 10 lead compounds were identified, re-synthesized and fully characterized. All 10 compounds showed high and broad activity against Gram-positive bacteria. The best manganese complex displayed low toxicity against human cells with a therapeutic index of >100. In initial mode of action studies, we show that it targets the bacterial membrane without inducing pore formation or depolarisation. Instead, it releases its carbon monoxide ligands around the membrane and inhibits the bacterial respiratory chain. This work demonstrates that large numbers of metal complexes can be accessed through combinatorial synthesis and evaluated for their antibacterial potential, allowing for the rapid identification of promising metalloantibiotic lead compounds.
Experimental and Theoretical Studies on the Reactions of Aliphatic Imines with Isocyanates
Authors: Cotter Etienne , Pultar Felix , Riniker Sereina , Altmann Karl-Heinz
Published: October 2023

In the context of a project aiming at the replacement of the 3-substituted β-lactam ring in classical β-lactam antibiotics by an N(3)-acyl-1,3-diazetidinone moiety, we have investigated the reaction of isocyanates with imines derived from allyl glycinate and differently substituted propionaldehydes. Imines of aromatic aldehydes with anilines have been reported to react with acyl isocyanates to give 1,3-azetidinones or 2,3-dihydro-4H-1,3,5-oxadiazin-4-ones, via [2+2] or [4+2] cycloaddition, respectively. However, neither of these products was formed with imines from allyl glycinate and 2-(mono)methyl propionaldehydes. α,α-Dimethylation of the imine enabled the [4+2] cycloaddition pathway, but the desired 1,3-diazetidinone products were not observed. Surprisingly, the imines obtained from thioesters of 2,2-dimethyl 3-oxo propionic acid reacted with aryl isocyanates or with benzyl isocyanate to give 2,2-dimethyl-2,4-dioxo-6-(aryl/akylthio)tetrahydropyrimidines, via thiol displacement and re-addition to a putative six-membered iminium intermediate. Such compounds have not been described in the literature so far. For aryl isocyanates, the reaction was insensitive to the nature of a para-substituent on the aromatic ring. The experimental results obtained for the reactions of acyl isocyanates with imines could be rationalized by DFT calculations. In addition, we have also shown that N(3)-acyl-1,3-azetidinone and 2,3-dihydro-4H-1,3,5-oxadiazin-4-one products can be distinguished based on experimental IR data in combination with theoretical reference spectra employing the IR spectra alignment (IRSA) algorithm. This discrimination was not possible by means of 1H, 13C, or 15N NMR spectroscopy.
Obtención de un abono orgánico a partir de la calcinación de huesos de cerdo (BIOCHAR)
Authors: Contreras Torres Paola Andrea
Published: October 2023

En este trabajo de investigación se muestran los resultados de la obtención de un abono orgánico a partir de la calcinación de huesos de cerdo, utilizando un método nuevo para la fabricación de abonos orgánicos mediante un biodigestor construido como piloto para la combustión piro lítica del hueso de cerdo siendo este autosostenible y tecnológicamente avanzado debido a que ayuda al medio ambiente, ya que se utiliza materia orgánica para el gas del prototipo y es herméticamente cerrado no necesitando ninguna clase de combustible ni genera ningún gas de combustión al medio mitigando así los efectos adversos del cambio climático. Por otro lado, ayuda en gran manera a los suelos ácidos de esta región del país, tratados siempre con químicos, dándoles una alternativa diferente y eficiente para los procesos de restauración de los suelos.
Factores que inciden en la reprobación de los alumnos en la asignatura “Álgebra Lineal”. Facultad de Ingeniería de la Universidad Nacional Autónoma de México
Authors: Sánchez Rodríguez Fernando
Published: October 2023

La División de Ciencias Básicas (DCB) de la Facultad de Ingeniería (FI) de la Universidad Nacional Autónoma de México (UNAM) ofrece los cursos relacionados con las áreas de Matemáticas, Física, Química y Biología, es decir, tiene a su cargo la importante tarea de proporcionar los conocimientos de las Ciencias Básicas, mismos que son fundamentales para que los estudiantes de ingeniería aborden de manera satisfactoria los cursos correspondientes a las Ciencias de la Ingeniería e Ingeniería Aplicada. En la DCB, los cursos relacionados con el área de matemáticas reportan los índices de aprobación menos satisfactorios, entonces resulta importante la identificación de los factores que inciden en la reprobación. Aunque el interés principal de la investigación se centra con el curso de Álgebra Lineal, se considera que las aportaciones obtenidas pueden extrapolarse para otras asignaturas de la DCB que presenten comportamientos similares. Entonces, en el trabajo se identifican los factores relacionados con estudiantes y profesores que inciden en la reprobación en la asignatura Álgebra Lineal y se establecen algunas recomendaciones que contribuyan a disminuir tal situación.
La extensión universitaria en ingeniería como herramienta para la transformación de los territorios
Authors: Botero Echeverri Gustavo , Marín Londoño Luis Fernando
Published: October 2023

Conocedores de la gran importancia que tienen las instituciones de educación superior en la formación del talento humano y el desarrollo de nuevas perspectivas para un mundo que se encuentra en constante desarrollo, hacen que los conocimientos impartidos dentro de las aulas de clase, se encuentren actualizados y a la vanguardia de las nuevas disposiciones mundiales, en este caso en el mundo de la Ingeniería. Partiendo de lo mencionado como una garantía sobre la calidad de los saberes que se adquieren en nuestras instituciones, además de las nuevas políticas Universitarias que buscan la integración en el desarrollo y la transformación de los territorios, por medio de la vinculación de la triada Universidad, Estado y Sociedad, por medio de los procesos vinculantes de la extensión Universitaria, es que se encuentra una herramienta de eficacia, constancia y calidad, para la participación en los proyectos bandera de cada uno de los territorios. Ahora bien, reconociendo a nuestro País como un territorio que se encuentra en el auge del desarrollo de la infraestructura en búsqueda de la competitividad mundial en cualquiera de los ejes económicos, en donde la conectividad de los medios de transporte y la sostenibilidad de los mismos como un eje transversal de vital importancia en la actualidad, es que se encuentra la herramienta que permite la vinculación de la Universidades con ese proceso, pues el manejo de cada una de las fases que se encuentran en los proyectos, pueden ser susceptibles a la participación Universitaria a través de la extensión. De lo anterior, se resalta nuestra participación como Universidad del Quindío en la ejecución de consultorías e interventorías a lo largo y ancho del País, sobre proyectos que han sido denominados como “proyectos bandera” para la transformación de los territorios, brindado garantías en temas se permanencia en el tiempo como Institución educativa, además de reconocimiento en la calidad de sus trabajos. Por último, las Universidades deben ser vistas como un espacio de generación y optimización de los conocimientos, que permite la participación ciudadana como espacio integrador en el desarrollo de los territorios, por lo cual y gracias a la presencia de las mismas a lo largo de todo el País, que permite tener el conocimiento particular de sus territorios y los conocimientos para su transformación pertinente.
Herramientas de learning analytics para caracterización del desempeño docente en el periodo 2018-2021
Authors: Caicedo Rodríguez Pablo , Castillo Landínez Sandra Patricia , Cerón Monje Valentina , Solarte Solano María Alejandra , Sánchez Ordóñez Eduar
Published: October 2023

La UNESCO ha propuesto en su agenda 2030 que la educación en el planeta sea de calidad y esté al alcance de todo ser humano; para cumplir con tal propósito, las instituciones educativas han explorado y aprovechado diferentes herramientas soportadas en las tecnologías de la información y las comunicaciones, constituyendo una alternativa para mejorar los procesos de enseñanza-aprendizaje. El auge de la smart education (educación inteligente) ha permitido la generación de gran cantidad de datos a partir del seguimiento a las actividades que realizan los actores académicos (estudiantes, profesores, administrativos e investigadores), los cuales son aprovechados para generar información valiosa mediante el uso de técnicas de inteligencia artificial (AI, artificial intelligence), analítica de aprendizaje (learning analytics) y analítica académica (learning academic); de esta forma se busca avanzar hacia una educación incluyente y de calidad. El ámbito académico es un ambiente ideal para aprovechar el potencial que ofrece la tecnología de la analítica de datos (data analytics) enfocada hacia la identificación de relaciones no evidentes en datos generados al interior de la institución educativa (admisiones, resultados de evaluaciones, notas finales de curso, contenidos curriculares, uso de plataformas académicas, encuestas o reportes, evaluación del desempeño docente, etc.) ) con el fin de generar indicadores de calidad, realizar la trazabilidad de los resultados de aprendizaje, formular planes de acción y soportar la toma de decisiones a nivel académico o administrativo. En este trabajo se presentan los resultados alcanzados mediante el uso de herramientas estadísticas clásicas, machine learning y Deep learning junto a procesamiento de lenguaje natural y análisis de sentimientos que caracterizó el desempeño docente en la Corporación Universitaria Autónoma del Cauca en el periodo 2018-2021.
WASTE-C para trazabilidad de residuos sólidos y su caracterización
Authors: Gaviria Hincapié Jorge Mario , Montoya Rendón Andrés Felipe , Villamizar Jaimes Aixa Eileen
Published: October 2023

El creciente aumento en la generación de residuos sólidos con lleva a efectuar estudios de diferente índole para un adecuado sistema de gestión de cada uno de ellos. Los desechos sólidos se han incrementado, y un alto porcentaje de ellos no son aprovechados, y terminan en el mejor de los casos en rellenos sanitarios. Por ello el propósito de este estudio es mostrar los resultados obtenidos, en particular el desarrollo del software WASTE-C en el Valle de Aburrá que contribuya a la planificación y gestión en general de los mismos en los diferentes municipios. El sistema para determinar la muestra y trazabilidad con código de barras contribuye a la gestión de los residuos para una efectiva disminución en la contaminación producida por este tipo de productos, porque además de su caracterización, puede mejorar el aprovechamiento de estos productos y una adecuada disposición final. La usabilidad del programa WASTE-C se evalúa con el modelo SQUARE. A través de una revisión de referencias se identifican los requisitos funcionales para posteriormente presentar un modelo de ingeniería de software a través de UML. Las características de usabilidad también se describen en el modelo de medición de la calidad del software. Se describen las evaluaciones realizadas para la aplicación del software. Se considera que este producto contribuye a la gestión de residuos sólidos al permitir el cálculo de tamaños de muestra para la caracterización en el proceso de cuarteo de residuos sólidos, brindando un insumo para la elaboración de planes de gestión de residuos sólidos en Colombia. Se identifican características que hacen usable el software, como la facilidad de uso de las funcionalidades, la sencillez de la información desplegada, el uso de íconos gráficos, apoyo alternativo para la comprensión a través de recursos como el uso de códigos de barras, entre otros.
La realidad aumentada como herramienta didáctica para potenciar el aprendizaje: caso RA- AFFORDANCES II en el laboratorio de manufactura flexible
Authors: Muñoz Moreno Andrés , Orozco Giraldo Consuelo
Published: October 2023

La Facultad de Ciencias Empresariales de la Universidad Tecnológica de Pereira atendiendo a las exigencias de estos tiempos modernos y de estas nuevas generaciones busca soluciones atractivas que impacten la formación de sus estudiantes, una de las estrategias que ha desarrollado con el objetivo aumentar los niveles de motivación, es hacer la presentación del laboratorio de manufactura flexible de una manera más moderna y digital haciendo uso de la tecnología a través de la realidad aumentada (RA). La RA sumada a lo que se conoce como Affordances, permiten una combinación en la que la RA explota las affordances (cualidades de un objeto o ambiente) del mundo real, proporcionando información adicional y contextual que aumenta de manera inmediata la experiencia de la realidad percibida por el estudiante (Squire & Klopfer, 2007). De esta forma, usando los celulares y descargando una sencilla y gratuita app, los estudiantes tienen acceso a la información de todas y cada una de las herramientas de la celda de manera individual y sincrónica por lo que la limitación del número de herramientas, así como la de tiempo desaparece porque cada estudiante puede centrar su atención en aquellas herramientas que más lo motivan y observarlas como modelos 3D estáticos.
UMA CIDADE SOBRE AS ÁGUAS: USO E QUALIDADE DAS ÁGUAS SUBTERRÂNEAS EM MOSSORÓ/RN
Authors: Peixoto Filipe Da Silva , Tôrres Lucas Matheus Garcia , Ferreira Isabel Cristina Silva , Silva Anderson Mikael De Souza
Published: October 2023

A cidade de Mossoró possui 70% da matriz hídrica composta por água subterrânea captada na própria área urbana, contudo, é notável a falta de informações sobre as águas subterrâneas locais. Este estudo buscou identificar o uso e qualidade das águas subterrâneas, bem como a descrição hidrogeológica. Para isso, foi compilado cadastros de poços com informações construtivas e de qualidade da água, cujas fontes foram o Sistema de Informação de Água Subterrânea – SIAGAS/CPRM, e a Companhia de Águas e Esgoto do Rio Grande do Norte - CAERN. Há ocorrência do Sistema Aquífero Apodi - SAA, composto pelo aquífero Barreiras, funcionando como aquífero de transferência, o aquífero Jandaíra como aquífero livre, e o aquitardo Quebradas, compondo uma camada confinante a semi-confinante para o aquífero Açu. Este, mais produtivo e sem restrições de uso quanto à qualidade, mas com sinais de perda qualitativa.
СУТНІСТЬ І СКЛАДОВІ МЕНЕДЖМЕНТУ КОНКУРЕНТОСПРОМОЖНОСТІ ЗАКЛАДІВ СФЕРИ ГОСТИННОСТІ
Authors: Черчик Лариса , Кувіка Ганна
Published: October 2023

У статті обгрунтовано необхідність та особливості формування системи менеджменту конкурентоспроможності для закладів сфери гостинності. Проаналізовано підходи до визначення сутності конкурентоспроможності, менеджменту конкурентоспроможності. Розроблено структурну схему системи менеджменту конкурентоспроможності закладів сфери гостинності, яка включає такі складові як мета, об'єкти, суб'єкти, предмет, принципи, функції та відповідний механізм. Система менеджменту конкурентоспроможності розглядається як сукупністю підсистем, а також процесів та комунікацій між ними, взаємодія яких забезпечує ефективне функціонування підприємства у конкурентному середовищі, його стабільний і безпечний розвиток у майбутньому за рахунок постійного розвитку потенціалу закладів сфери гостинності. Деталізовано також функціональний та процесний підходи у формуванні менеджменту конкурентоспроможності, що має більше практичне значення і передбачає виділення загальних та специфічних функцій та послідовних етапів їх реалізації в основних функціональних сферах менеджменту (маркетинговій, фінансовій, інноваційній, проєктній, менеджменту персоналу та якості).
КРОС-ФУНКЦІОНАЛЬНА ВЗАЄМОДІЯ ТА КОМУНІКАЦІЇ В УМОВАХ КРИЗИ
Authors: Ющишина Лариса , Бортнік Світлана
Published: October 2023

У статті розглянуто питання використання крос-функціональних команд як інструменту для швидкої реакції на зміни в умовах кризи. Особлива увага приділена дослідженню крос-функціональної взаємодії та комунікаціям в умовах кризи. Обґрунтовано, що в умовах кризи залучення крос-функціональних команд є особливо ефективним, оскільки вони забезпечують швидку та ефективну взаємодію між різними функціональними зонами компанії. Встановлено взаємозв’язок між ефективним підходом до комунікацій в умовах кризи та організаційною роботою крос-функціональної команди. Виокремлено переваги крос-функціональної співпраці, проаналізовано складнощі та реальні проблеми поточної взаємодії крос-функціональних команд. Сформовано напрями удосконалення побудови комунікацій та інформаційних потоків в умовах кризи. Визначено характер комунікаційної системи залежно від типу організаційних структурних, що використовується для побудови управлінської системи. Проаналізовано відмінності комунікаційного реагування, залежно від типу та рівня кризи. Доведено, що крос-функціональна взаємодія зумовлює синергетичний ефект, що є відмінним від сумарної роботи окремих структурних підрозділів організації.
İlkokulda Görev Yapan Öğretmen ve İlkokul Öğrencilerinin Etkili Okulun Fiziksel Özelliklerine İlişkin Görüşlerinin İncelenmesi
Authors: KOCAASLAN Rukiye , ÖZENÇ Emine Gül
Published: October 2023

Bu araştırma ilkokulda görev yapan öğretmen ve öğrencilerinin etkili okulun fiziksel özelliklerine ilişkin görüşlerini tespit etmek ve elde edilen bulgular doğrultusunda öneriler geliştirmek amacıyla hazırlanmıştır. Araştırmanın kavramsal bölümlerinin tamamlanmasında literatür taraması yönteminden faydalanılmıştır. Araştırmanın uygulama bölümünde nitel araştırma yöntemi kullanılarak 15 öğretmen ve 15 öğrenci ile birebir görüşmeler yapılmıştır. Öğrencilere araştırmacı tarafından oluşturulan görüşme soruları iletilerek içtenlikle yanıtlamaları istenmiştir. Araştırmaya dahil edilen bireylerden toplanan veriler karşılaştırmalı olarak analiz edilerek bulgular ortaya koyulmuştur. Araştırma sonucunda okulların fiziksel özelliklerinin eğitim ve öğretim açısından oldukça önemli olduğu, öğretmenlerin hem sınıf ortamında hem okulun diğer bölgelerinde işlerini daha iyi yapabilmelerinde önem arz ettiği ve okulun fiziksel ortamlarının öğrencileri doğrudan etkilediği tespit edilmiş ve bu yönde öneriler ortaya koyulmuştur.
Effectiveness of mahogany seed flour (Swietenia macrophylla) as a bioinsecticide against mortality of Sitophilus zeamais motsch in post-harvest grains
Authors: Khairunnisa Eka Nurriza , Rian Ira Gusti , Ritonga Nia Boru , Saadah Raudhatus , Rarassari Madyasta Anggana
Published: October 2023

Research has been conducted on the effect of giving Mahogany seed meal (Swietenia macrophylla) on the mortality of the beetle Sitophilus zeamais Motsch. The method used is an experimental method with a complete randomized design consisting of 6 treatments and 4 repeats. The treatment consisted of controls A0 (0%), A1 (2%), A2 (4.8%), A3 (7.4%), A4 (13.0%), and A5 (17.4%). Mahogany seed flour with a concentration in each treatment was mixed with granulated corn to a weight of 50 grams, placed 20 Sitophilus zeamais beetles and observed for 24, 48, 72 and 96 hours. Data were analyzed by anava calculation and BJND test at 24-hour observation, BNT test at 48-hour observation and BNJ test at 72- and 96-hour observations. The concentration of 17.4% gave the greatest beetle mortality effect, namely 75% at 24 hours, 81.25% at 48 hours, 91.25% at 72 hours and 100% at 96 hours from the number of 20 beetles tested. This study also produced KL50 values for mahogany seed flour, namely 11.90% at 24 hours, 10.41% at 48 hours, 8.69% at 72 hours and 7.23% at 96 hours.
Ethnobotany of Food Plants in The Penghulu Tribe Community in Sarolangun, Jambi
Authors: Has Dini Hardiani , Marpaung Sutan Sahala Muda , Jati Erwika Dhora , Hartati Bunga Resa , Fitrianto Imam , Yulianti Iis , Nugroho Septian Putra Adi , Rahmila Yulizar Ihrami , Rahmayanti Fetty Dwi , Fadilah Ratnawaty , Bukhari Bukhari , Simanjuntak Asnika Putri , Algiffari M. Fauzhan , Lubis Dita Anggriani
Published: October 2023

Tribal community in the Bukit Bulan area, Limun District, Sarolangun Regency, Jambi. This research aims to identify the ethnobotany of food plant species by the Penghulu Tribe community in Sarolangun Regency, Jambi Province. This research was conducted in Napal Melintang and Meribung Villages. Research method ethnobotanical data on food plants were obtained through qualitative data collection techniques through in-depth interviews, in contrast, potential data were obtained through vegetation analysis and exploration methods. The study's results identified as many as 88 species from 35 families of food plants originating from cultivation and wild plants, which herbaceous plants dominated. Based on the results of interviews, there are many food plant species in the forest habitat. The part of the plant that is widely used by the community is fruit, and this is because people generally grow fruit in their yards and community gardens. Cultivators mostly use food plants for direct consumption. Conclusion this research The Penghulu tribe community's dependence on food plants is still high because they can utilize, gather, and process them. 88 species of food plants have been identified from 35 families, of which 77 produce carbohydrates, vegetables, and fruit.