bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating the Investment Landscape in MENA: The Role of Economic Growth, Trade, Financial Development, and Governance in FDI Attraction
Authors: Ozturk Ozcan , Nagayev Ruslan
Published: September 2024

This paper investigates the determinants of Foreign Direct Investment (FDI) in the Middle East and North Africa (MENA) region, with a particular focus on economic growth, trade policy, financial development, and governance indicators such as effective governance and political stability. Employing a robust fixed effect panel data analysis and utilizing data for 18 selected MENA countries covering the years 2000-2022, this study examines the complex interplay between the variables and their collective influence on FDI flows into the MENA region. The analysis reveals that economic growth and trade openness are significant positive determinants of FDI, highlighting the importance of fostering a robust economic environment and maintaining open trade policies. Financial development and business freedom exhibit complex relationships in the regression models, suggesting the need for holistic reforms addressing other structural and institutional factors. Moreover, among the governance indicators, effective governance and political stability emerge as crucial elements in attracting FDI, with significant positive impacts observed in both correlation tests and coefficient estimations. Conversely, high dependence on oil revenues and high real interest rates deter FDI, emphasizing the need for economic diversification and macroeconomic stability. Based on these findings, the paper proposes a set of policy recommendations, including promoting economic growth, enhancing trade openness, improving institutional quality, diversifying the economy, and maintaining macroeconomic stability to create a favorable environment for FDI. These strategies will drive sustainable development, economic diversification, and long-term growth in the MENA region.
Utilization of coffee by-products for the production of alcoholic and non-alcoholic beverages and their physiochemical and sensory characteristics
Authors: Thagunna Bishal , Bhattarai Simran , Poudel Ranjita , Poudel Riya Roshani , Karki Laxmi , Sharma Shristi Poudel
Published: September 2024

Coffee pulp is the first byproduct of coffee processing. It contains contaminants due to its composition and production volume. This study evaluates coffee by-products wine from fresh coffee pulp, used as a substrate, along with cascara tea from dried coffee pulp. About 40 % of pulp was obtained during the wet processing of coffee. The pulp was dried directly in the sun for 3–4 days until the moisture content of the cascara drink was below 8 %. Similarly, for the alcoholic beverage (wine), the must was processed to the TSS (24°Brix), and the fermentation process was carried out for up to 10–12 days until the TSS was down to 10°Brix. After the fermentation was completed, the fermented wine was kept for secondary fermentation where it undergoes aging or clarification. The clarified wine was then filled into sterilized glass bottles for further use. The chemical composition of coffee pulp (moisture, ash, crude protein, acidity, fat, crude fiber, caffeine, tannin, reducing sugar, TSS, and flavonoids) was analyzed. Both beverages were also subjected to sensory analysis and chemical analysis
Caffeine, tannin, pH, and acidity of the non-alcoholic beverage were 220 mg/L, 45.7 mg/L, 4.16 and 1.24 %, respectively. Alcohol, methanol, ester, aldehyde, pH, TSS, acidity, caffeine, tannin, and flavonoid were 10.58 ABV %, 295 mg/L, 75.26 ppm, 10.12 ppm, 3.2, 10°Brix, 0.52 %, 28.96 ppm, 280 mg/L and 405 mg/g, respectively. The alcoholic and non-alcoholic beverages made from coffee pulp were superior in terms of sensory attributes. Therefore, it is possible to develop both beverages from coffee pulp and maximum utilization of waste coffee pulp
Brick wall quantum circuits with global fermionic symmetry
Authors: Richelli Pietro , Schoutens Kareljan , Zorzato Alberto
Published: September 2024

We study brick wall quantum circuits enjoying a global fermionic symmetry. The constituent 2-qubit gate, and its fermionic symmetry, derive from a 2-particle scattering matrix in integrable, supersymmetric quantum field theory in 1+1 dimensions. Our 2-qubit gate, as a function of three free parameters, is of so-called free fermionic or matchgate form, allowing us to derive the spectral structure of both the brick wall unitary U_FUF and its, non-trivial, Hamiltonian limit H_{\gamma}Hγ in closed form. We find that the fermionic symmetry pins H_{\gamma}Hγ to a surface of critical points, whereas breaking that symmetry leads to non-trivial topological phases. We briefly explore quench dynamics for this class of circuits.
Correlación entre acoso, ciberacoso y trastornos emocionales en estudiantes de colegios públicos de Floridablanca
Authors: Licona Fernández Cesia , Vásquez Caballero Diego Andrés
Published: September 2024

El objetivo de esta investigación fue analizar la relación entre la presencia de trastornos emocionales y el acoso escolar en los estudiantes de sexto a noveno grado de las instituciones educativas públicas de la ciudad de Floridablanca (Colombia). El diseño del estudio fue cuantitativo correlacional. Los instrumentos utilizados fueron la prueba de tamizaje cyberbullying y el Sistema de Evaluación de Niños y Adolescentes (SENA). Se evaluaron 76 menores que cumplen el rol de víctima o agresor, y los resultados obtenidos indicaron que un alto porcentaje de los involucrados en el acoso escolar como víctimas o agresores cara a cara o en línea presentan desajustes emocionales. Los datos descriptivos muestran que en Floridablanca (Colombia) aún hay fracciones de acoso escolar por debajo de la prevalencia internacional; sin embargo, existe una alta proporción de estudiantes en riesgo de asumir algún rol en el acoso escolar. Se concluyó que la Psicología es una disciplina científica que aporta herramientas para abordar los trastornos emocionales adscritos al acoso escolar. Que deben recibir tratamiento psicológico todos los involucrados en el acoso escolar en cualquiera de sus roles. Esta investigación puede considerarse como insumo para futuros trabajos que pretendan formular acciones de intervención para el acoso escolar y el trabajo de los trastornos emocionales qu e genera este problema.
Examining the effect of geopolitical risks on renewable energy consumption in OECD countries
Authors: Bello Saheed , Abdulwahab Hassan Yusuf
Published: September 2024

As urgent actions are required to accelerate the transition to a more environmentally friendly energy sector and global economy, the rising geopolitical risks defined as any tensions that disrupt the peace of local and international relations pose greater uncertainty to the rapid renewable energy deployment in supporting the carbon-neutrality ambitions. Thus, this paper investigates the influence of geopolitical risks on renewable energy consumption in OECD countries over the period 1970–2022 to address potential estimation biases from ignoring recent events such as COVID-19 and the ongoing Russia-Ukraine war. The paper applies a system GMM to a cross-country panel dataset while controlling for per capita income, carbon dioxide (CO2) emissions, economic globalization, and natural resource rents to deal with all possible sources of endogeneity. The results show that geopolitical risks reduce the consumption of renewable energy, with a magnitude of 0.22 percentage points. In addition, CO2 emissions and natural resource rents adversely affect the amount of renewable energy consumption. However, economic growth and globalization promote the demand for renewable energy. Therefore, the empirical findings suggest that geopolitical risks play a crucial role in the consumption of renewable energy.
Acknowledgement The financial support from Engineering and Physical Sciences Research Council (EPSRC) under the project EP/T022930/1 is gratefully acknowledged. Authors would like to thank Prof. David Reiner and the Editor for their constructive comments and suggestions.
Multipolar management of organization
Authors:   Central Economics & Mathematics Institute, Russian Academy of Sciences, Kleiner George B. ,   Financial University under the Government of the Russian Federation
Published: September 2024

Purpose: to explore the most well-known configurations of the organization’s governance system, to identify their advantages/disadvantages and to come up with a new structure of management system built upon the poles of an organization which represent the seat power of influence on the major components of its internal environment. Methodology: the paper being theoretical employs the systemic economic theory, the theory of social leadership, the elements of the theory of psychological types to substantiate the “pole” structure of organization as a mean of strengthening the integrity of the organization and improving managerial performance in unstable external environment. Findings: the management toolkit of organization has been expanded due to a new multipolar management system based on separating the entire body of the employees into groups around a limited number of intra-organization poles — specific attractors in the internal domain of an organization. The study shows that the upper level of the poles structure includes four poles which correspond to the four basic types of socio-economic systems. From the managerial perspective, these poles are represented by four types of leaders which can be characterized as inspirational, intellectual, cultural and spiritual. Their activities form a unique field structure in the intra-company space that, due to the emerging pull-and-push factors, influences the work of both internal and external participants of the organization’s activities. Originality and contribution: the paper synthesises three approaches to company’s management principles — systemic, social and psychological. The original results obtained in the paper hold out the prospect that the concept of four-polar management of economic units through the theory of social leadership can be harmonized with the concept of managing macro- and meso-level objects from the external environment of the organization.
Transformation of marketing practices on the pharmaceutical market in Russia: New challenges and opportunities
Authors:   Graduate School of Business, HSE University, Oborevich Anna A. , Tretyak Olga A. ,   Graduate School of Business, HSE University
Published: September 2024

Purpose: to search and systematize the directions of marketing practices transformation in the situation of restrictions on the Russian pharmaceutical market based on the revised dynamic “marketing mix” approach. Methodology: the empirical part of the study is designed according to the conceptual model which was built at the stage of academic literature and consulting reports analysis. The methodology rests on the dynamics of marketing tools transformation caused by shock changes in the external environment. The main research method is in-depth interviews with representatives of 11 pharmaceutical manufacturing companies: directors/heads of marketing departments and related business units, leading marketing specialists with, on average, 12 years of work experience in the pharmaceutical industry. Findings: based on the empirical research results, there was recorded the initial reaction of experts to market changes, as well as there were identified the following directions of marketing practices transformation: the key changes on the pharmaceutical market in the context of the ESG agenda, the impact of the COVID-19 pandemic, and the strengthening of international sanctions in 2022; the main shifts in the transformation of the key players’ roles; the directions of changes of the marketing complex ‒ “marketing mix”. Originality and contribution: the study comprehensively reveals the transformations in marketing management functions on the Russian pharmaceutical market with the emphasis on the commercial segment taking into account three “drivers” in the context of critical points of change (milestones): the ESG agenda, COVID-19 and the increased pressure of sanctions since 2022. From a theoretical point of view, the paper contributes to the theory of the evolutionary development of marketing in the context of “driving forces” (milestones or events that have greatly changed the landscape of marketing functioning). From the practical side, the study can serve as support for top managers of companies to make decisions how to improve marketing practices during the drastic environmental changes.
Nanoparticles based Strategies for Treating and Managing Battle against Malaria: An Overview
Authors: Sharma Chandan , Jain Divya , Bainsal Neeraj , Bhardwaj Rahul , Singh Kuldeep
Published: September 2024

:

Malaria is a life-threatening disease spread via female Anopheles mosquitoes. Assortments of factors are causing the trouble i.e., (i) fierce
opposition posed by the plasmodium life cycle and intracellular localization for pathogens in hepatocytes and erythrocytes; (ii) The decisive
physical and chemical properties among most antimalarial drugs, that exhibit an amphiphilic property allowing them to be widely circulated in and
out of body tissues since administration and quickly fully exploited in the liver; (iii) The unflattering fluidic circumstances confronted in blood
flow that affect the relationship of ionic parts to target tissue. So rather than concentrating the entire energy on establishing novel medications, it is
preferable to effort into refining operative medicine conveyance transporters to overcome these downsides. Anti-paludism medications have been
effectively distributed via nanomaterials on adjacent concentrations high sufficient on the way to slay the pests and evade the growth of treatment
obstruction, although upholding a small general amount to foil uncomplimentary poisonous sideways things. As of now, a few nanostructured
frameworks like liposomes or dendrimers have been demonstrated to be fit for working on the viability of anti-malarial treatments. These
nanoparticles are an auspicious medication conveyance automobile and could be utilized as remedial techniques intended for battling pests. This
audit is expected to scrutinize the utilization of nanoparticles to further develop medicine effectiveness at various phases for both human and
vampire congregations of miasm vermin.
Platelets in Cancer: From Hemostasis to Metastasis: A Review
Authors: Yadav Satyam , Ranjan Ravi , Kumar Ranjeet
Published: September 2024

Platelets are small anucleated blood cells that play a vital role in preserving the integrity
of tissue because of their hemostatic properties. However, through their interactions with leukocytes,
they also have important functions in immunological responses and inflammation. Platelets
have an impact on the tumor's development and metastasis at different stages of cancer. They promote
angiogenesis and metastasis by modifying endothelial activation, improving leukocyte migration
to tumor locations, and changing inflammatory conditions. Patients with cancer frequently
have aberrant platelet activity, which accelerates the progression of the illness. Tumor cells that
penetrate the bloodstream stimulate platelets, which causes the tumor cells to take on a mesenchymal-
like phenotype and widen the permeability of the endothelium. As a result, tumor cell-platelet
emboli are created. In addition, platelets draw in myeloid cells, shield tumor cells from immunological
reactions and shear stress, and aid in their extravasation into distant organs. Ultimately,
growth factors derived from platelets help create micrometastatic foci. With an emphasis on current
advancements in the area, this review clarifies the intricate mechanisms of platelet activation
and their interactions with cancer cells.
A Rare Presentation of Cryoglobulinemic Vasculitis Associated with Primary Sjögren’s Syndrome
Authors: Metyas Caroline , Lee Joshua Donguk , Jun Jenny Ann , Arkfeld Daniel G.
Published: September 2024

Introduction:

Sjögren’s syndrome is a chronic autoimmune disorder that results in dry
eyes and mouth. It is rarely associated with cryoglobulinemia, the agglutination of cryoglobulins
at cold temperatures that leads to systemic inflammation and organ damage. We have, herein, presented
a case of Cryoglobulinemic Vasculitis (CryoVas), which presents as cryoglobulinemic
glomerulonephritis and Central Nervous System (CNS) vasculitis and peripheral neuropathy.

Case Report:

A 52-year-old woman with a past medical history of Sjögren's syndrome was admitted
to the intensive care unit with severe hyponatremia, orthopnea, and progressive lower extremity
weakness, and was found to have an intradural extramedullary hematoma with mass effect in
the thoracic spine and diffuse hyperintense cord signal abnormality in thoracic spine suggestive of
intermixed proteinaceous or hemorrhagic material. Further testing demonstrated that the patient experienced
worsening neuropathy, proteinuria, hematuria, declining renal function, and the presence
of cryoglobulins in the blood. After a thorough examination and a renal biopsy, the patient
was diagnosed with cryoglobulinemic glomerulonephritis and cryoglobulinemic vasculitis of the
spine. The patient was treated with rituximab and pulse-dose steroids, with which the patient exhibited
improved renal function and resolution of a previously seen intradural hematoma on repeat
MRI.

Conclusion:

We have, herein, discussed a rare case of cryoglobulinemic vasculitis that has led to
a rare CNS manifestation and concomitant cryoglobulinemic glomerulonephritis. This suggests
that clinicians should consider cryoglobulinemic vasculitis as the etiology that could manifest
with multiorgan involvement, especially in patients with underlying rheumatic diseases.
Polyphenol-Mediated Modulation of Non-Coding RNAs: A New Therapeutic Approach for Hypertension - A Review
Authors: Gareev Ilgiz , Beylerli Ozal , Ilyasova Tatiana , Wang Chunlei
Published: September 2024

:

Hypertension (HTN) is a leading risk factor for cardiovascular diseases (CVDs) and a
major contributor to global morbidity and mortality. Conventional pharmacological treatments
have been effective but are often accompanied by side effects and do not address all pathological
aspects of the disease. Recent advances in molecular biology have identified non-coding RNAs (ncRNAs),
including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), as key regulators
in the pathogenesis of hypertension. These ncRNAs influence various cellular processes, such
as gene expression, vascular tone, and inflammation, making them promising targets for therapeutic
intervention. This review explores the potential of polyphenols, a diverse group of phytochemicals
with potent antioxidant and anti-inflammatory properties, in modulating ncRNA expression
and function. We discuss how polyphenols, such as epigallocatechin-3-gallate (EGCG), resveratrol,
curcumin, and quercetin impact the regulation of ncRNAs, particularly focusing on their roles
in reducing oxidative stress, improving endothelial function, and ameliorating vascular remodeling
associated with hypertension. The review synthesizes current evidence from both in vitro and
in vivo studies, highlighting significant findings and the mechanisms by which polyphenols exert
their effects on ncRNA-mediated pathways.

:

Moreover, we address the challenges of translating these findings into clinical applications, including
issues related to bioavailability, dosing, and the complex interactions of polyphenols with
other cellular components. Future directions for research are suggested, with an emphasis on the
need for comprehensive clinical trials to establish the efficacy of polyphenol-based therapies targeting
ncRNAs in hypertension management. By targeting ncRNAs, polyphenols offer a novel
therapeutic strategy that could enhance the treatment landscape for hypertension and potentially
other cardiovascular conditions.
Blockchain Security:"Botnets and Bitcoin Mining” - A Study on the Impacts and Countermeasures
Authors: Kundu Krishanu
Published: September 2024

Introduction:

Botnets have become a significant threat to cybersecurity, as they can
be used for a wide range of malicious activities, including Distributed Denial-of-Service (DDoS)
attacks, spamming, and cryptocurrency mining. Bitcoin Mining, in particular, has become a
lucrative target for cybercriminals, as it requires massive computing power and can generate
significant profits.

Methods:

In this paper, the author presents a study on a botnet that uses an HTA file to gain
initial access and execute code on a victim's device, followed by the installation of mining
software to infect the device and bitcoins.

Results:

The author analyzes the botnet's behaviour, including its evasion techniques and Bitcoin Mining
activities, and discusses the implications of current findings for cybersecurity and Bitcoin Mining.

Conclusion:

Future research should also investigate the use of different command and control
servers and other advanced attack frameworks in botnet operations and examine the potential
connections between botnets and other cybercrime activities, such as ransomware and espionage.
From Enzyme to Vaccine: Preliminary Insights into the Immunogenic Epitopes in Adenylate Kinase 8 (ADK8) of Echinococcus granulosus
Authors: Ghamazi Nilofar , Azimi-Resketi Mojtaba , Najafi Alireza , Ghiabi Shadan , Asghari Ali , Fathollahzadeh Mohammad , Majidiani Hamidreza
Published: September 2024

Background:

Globally, developing livestock countries are affected by Cystic Echinococcosis
(CE), a neglected zoonosis. Thus, vaccination would help to prevent this neglected zoonosis.

Objective:

This study aimed to predict the primary biochemical characteristics of E. granulosus
Adenylate Kinase 8 (ADK8) and its potential B- and T-cell-binding epitopes as a candidate for
vaccination.

Methods:

Prediction were conducted on multiple web servers to identify immunogenic epitopes as
well as biochemical, antigenic, structural, and subcellular properties.

Results:

The extracellular 38.78 KDa protein possessed no allergenic fragments, while it showed
hydrophilicity (GRAVY: -0.239), wide thermotolerance (aliphatic: 98.02), and 36 post-translational
modification sites. The secondary structure mostly included helices and random coils, and the
best-generated 3D model by the Robetta server had a confidence score of 0.79. Three servers identified
common B-cell epitopes and evaluated them for solubility, allergenicity, and antigenic properties.
Furthermore, following the screening, MHC-associated epitopes for humans and mice were
predicted in the E. granulosus ADK8.

Conclusion:

These results provide a basis for future research into the development of a proper
vaccine against CE. Additional empirical studies using the protein and/or its epitopes alone or in
combination with additional antigens are demanded.
Insights into the Pathogenesis and Treatment of Chemotherapy-Induced Neuropathy: A Focus on Oxidative Stress and Neuroinflammation
Authors: Yu Jiaqi , Fu Yuanfeng , Xu Weifeng , Ding Ren-Bo , Bao Jiaolin
Published: September 2024

Cancer is a high-morbidity disease prevalent worldwide. Chemotherapy is the primarily
used regimen for cancer treatment; however, it also brings severe side effects. Chemotherapy-induced
Peripheral Neuropathy (CIPN) and Chemotherapy-induced Cognitive Impairment (CICI)
are two main complications occurring in chemotherapy. They are both associated with nervous
system injury and are therefore collectively referred to as Chemotherapy-induced Neuropathy
(CIN). CIPN induces neuralgia and numbness in limbs, while CICI causes amnesia and cognitive
dysfunction. Currently, there are no effective therapeutics to prevent or cure CIN, so research into
new drugs to alleviate CIN becomes urgent. Oxidative stress and neuroinflammation are the common
pathogenic mechanisms of CIPN and CICI. Excessive Reactive Oxygen Species (ROS) and
pro-inflammatory cytokines cause peripheral nervous system damage and hence CIPN. Peripheral
ROS and cytokines also change the permeability of the blood-brain barrier, thereby increasing
oxidative stress and neuroinflammation in the central nervous system, ultimately leading to CICI.
Several antidepressants have been used to treat CIN and exhibited good clinical effects. Their potential
pharmacological mechanism has been reported to ameliorate oxidative stress and neuroinflammation,
guiding a new feasible way for effective therapeutic development against CIN. This
mini-review has summarized the latest advances in the research on CIN with respect to clinical status,
pathogenesis, and treatment. It has also discussed the potential of repurposing antidepressants
for CIN treatment and prospected the strategy of developing therapeutics by targeting oxidative
stress and neuroinflammation against CIN.
How can ecology-based civics learning media "PKN Ekologi" foster ecological competence in students?
Authors: Feriandi Yoga Ardian , Ulfah Risti Aulia
Published: September 2024

This study aims to evaluate the effectiveness of learning media in Citizenship education learning for junior high school students. PKN Ecology is a digital-based learning media that adopts the principle of augmented Reality. This study was conducted using a quasi-experimental method with the control and experimental classes taken from students of SMPN 11 Madiun City, East Java. The number of students used as the research sample is 83, n = 83, consisting of 42 in the experimental and 41 in the control classes. The results showed that the Ecological Civics Media was proven to impact improving ecological competence for middle school students positively. In addition, ecological civics media has been proven to increase student interest in enhancing learning.
Personal social responsibility in ecological citizenship: Dimensionality and scale measurement with Aiken Index Analysis
Authors: Istiqomah Annisa , Murdiono Mukhamad , Hajaroh Mami
Published: September 2024

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UJI STABILITAS FORMULASI MASKER GEL PEEL OFF EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.)
Authors: Sari Eni Kartika , Ariska Ici , Putri Mega Karina
Published: September 2024

AbstrakEkstrak daun pepaya mengandung enzim papain, alkaloid, pseudokarpain, glikosida, karposid dan saponin yang memiliki aktivitas sebagai antibakteri. Daun pepaya dapat diaplikasikan dalam bentuk masker gel peel off. Pembuatan sediaan masker gel peel off menggunakan basis yaitu HPMC dan PVA. Pengujian stabilitas fisik gel dilakukan untuk menjamin kualitas, keamanan dan stabil pada penyimpanan. Penelitian ini bertujuan untuk mengetahui formulasi dan uji stabilitas fisik sediaan masker gel peel off ektrak etanol daun pepaya (Carica papaya L.) dengan variasi konsentrasi HPMC dan PVA.Tahapan pada penelitian ini meliputi pembuatan ekstrak daun pepaya dengan cara maserasi menggunakan pelarut etanol 96%, pembuatan sediaan masker gel peel off ekstrak daun pepaya dengan variasi konsentrasi HPMC dan PVA (3%: 9%), (4%: 8%), dan (5%: 7%) serta uji stabilitas fisik sediaan yang meliputi organoleptik, homogenitas, pH, daya sebar dan waktu kering menggunakan metode cycling test pada suhu 4oC dan 40oC sebanyak 6 siklus. Data yang diperoleh dianalisis statistik dengan menggunakan uji One Way Anova dan uji T.Hasil penelitian uji stabilitas sediaan masker gel peel off ekstrak etanol daun pepaya (Carica papaya L.) menunjukkan bahwa konsentrasi HPMC dan PVA (4%: 8%) mempunyai stabilitas fisik paling baik yaitu memenuhi syarat organoleptik, homogenitas, pH, daya sebar, waktu mengering. Kombinasi HPMC dan PVA dapat berpengaruh terhadap sifat fisik sediaan (daya sebar dan waktu kering).Kata kunci: Ekstrak daun pepaya, gel peel off, HPMC dan PVA, uji stabilitas
Keanekaragaman Cacing Tanah Pada Lahan Sawah Tercemar Residu Pestisida
Authors: Ramadhanti Nur Rizki Putri , Aminatun Tien , Rakhmawati Anna , Octavia Bernadetta , Suhartini Suhartini
Published: September 2024

Penelitian ini bertujuan mengetahui kondisi fisikokimia dan keanekaragaman cacing tanah pada lahan sawah tercemar residu pestisida di Wonokerto, Turi, Sleman, Yogyakarta. Penelitian ini merupakan jenis penelitian observasi yang mendeskripsikan keanekaragaman cacing tanah di lahan tercemar residu pestisida terutama golongan organofosfat. Lahan penelitian meliputi lahan A dengan umur penggunaan pestisida organofosfat lebih dari 1 tahun dan lahan B berumur kurang dari 1 tahun. Pengambilan sampel menggunakan teknik handsorting pada petak 25x25x25cm. Sampel diidentifikasi di Laboratorium Lingkungan FMIPA UNY. Analisis data secara deskriptif berdasarkan hasil indeks keanekaragaman Shannon–Wienner. Hasil uji kandungan pestisida golongan organofosfat lahan A dan lahan B adalah tidak terdeteksi. Namun berdasarkan paparan petani, lahan A dan lahan B menggunakan pestisida golongan organofosfat dengan bahan aktif profenofos selama lebih dari 1 tahun. Untuk itu, ke dua lahan diperkirakan tercemar pestisida golongan organofosfat. Hasil uji fisikokimia tanah lahan A bertekstur geluh pasiran dengan kandungan bahan organik dan C organik lebih rendah serta pH, KTK, N total, P tersedia, dan K tersedia lebih tinggi dibanding lahan B bertekstur pasir geluhan. Tingkat keanekaragaman cacing tanah adalah rendah pada ke dua lahan dengan indeks keanekaragaman tertinggi 0,617 pada lahan B berumur kurang dari 1 tahun penggunaan pestisida golongan organofosfat.Kata kunci: keanekaragaman, cacing tanah, cemaran, residu pestisida.This research aims to discover physicochemical conditions of soil and diversity of earthworms in fields contaminated pesticide residues in Wonokerto, Turi, Sleman, Yogyakarta. This research is observational research describes earthworms’ diversity in fields contaminated pesticide residues, especially organophosphate. Research area includes field A, with exposure to organophosphate pesticides for more than 1 year, and field B less than 1 year. The handsorting was employed as a sampling technique in plots of 25x25x25cm. Samples were identified at Environmental Laboratory FMIPA UNY. Data analysis was conducted descriptively based on results Shannon–Wienner diversity index. The test results show pesticide organophosphate content in two fields was undetected. However, based on the explanation from farmers in field A and B, used organophosphate pesticides with active ingredient profenophos more than 1 year. It is estimated, both fields will remain contaminated organophosphate pesticides. The soil physicochemical tests indicate field A, a sandy loam texture, had lower organic matter content and organic C with higher pH, CEC, total N, available P, and available K compared to field B with a loamy sand texture. Diversity level of earthworms is low in both fields with highest index being 0,617 in field B, less than 1 year using organophosphate pesticides.Keywords: diversity, earthworms, contamination, pesticide residue.
SPECIES DISTRIBUTION OF DEER FEEDS (Muntiacus muntjak Zimmermann, 1780) AND ITS COMMUNITY COMPOSITION IN SERMO WILDLIFE RESERVE AREA, SPECIAL REGION OF YOGYAKARTA
Authors: Rahmadian Desti , Suhandoyo Suhandoyo , Nurvianto Sandy
Published: September 2024

Muntiacus muntjak is a native Southeast Asian mammal, widely distributed in Sumatra, Bangka Belitung, Riau Islands, Java, Bali, Nusa Tenggara, and Kalimantan. Its existence is increasingly threatened by deforestation and habitat degradation. Habitat integrity and the sustainability of forest plant species as a source of feed for deer in the Sermo Wildlife Reserve area need to be maintained, in order to ensure the survival of these animals in their natural habitat. This research’s aims to determine the type of Muntiacus Muntjak feed, describe the distribution pattern of Muntiacus muntjak feed plant species and identify the composition of lower plants in Sermo Wildlife Reserve Area.The method wich used to quantify the structure and composition of vegetation types is systematic random sampling used 46 plots with measuring 1 m x 1 m and 2 m x 2 m for grass and lower plants datas as the material to epidermal analysis and the calculation of the total dry weight. Faecal analysis was conducted at the Wildlife Laboratory, Faculty of Forestry UGM. The distribution of deer feed plant species that have been identified will be processed using ArcView GIS 10.8 based on the coordinates where the feeds species found in Sermo Wildlife Reserve.The results showed that there were 19 species of lower plants identified as deer feed with uniform and clustered species distribution patterns. The community composition of lower plant species in Sermo Wildlife Reserve consists of 93 species from 49 different families.
STUDI PERILAKU HARIAN CAPUNG SAYAP ORANYE (Brachythemis contaminata) DI EMBUNG TAMBAKBOYO, CONDONGCATUR, SLEMAN
Authors: Bagaswara Anjas Arya , Sutoyo Berliana Fatikasari , Mufidah Fathiyya Tsani , Rahmawati Yunita
Published: September 2024

Capung merupakan jenis serangga yang termasuk dalam ordo odonata yang memiliki habitat di perairan dengan jumlah sekitar 1.287 spesies capung di Indonesia. Brachythemis contaminata merupakan salah satu jenis capung yang mudah ditemukan dengan aktivitas terbang hanya sebentar dan hinggap berlama-lama pada vegetasi di perairan dalam berbagai kondisi lingkungan. Capung Brachythemis contaminata dapat ditemukan bertengger di tepi perairan secara berkelompok sehingga dapat diamati perilaku individu maupun interaksi dengan sesama jenisnya. Jenis capung ini memiliki masa aktif sejak pagi hingga sore hari. Aktivitas yang sering dilakukan oleh capung ini adalah bertengger di ranting, baik pada rawa, savana, ataupun di ranting pepohonan. Penelitian ini bertujuan untuk mengetahui perilaku alami capung Brachythemis contaminata dan mengetahui persentase tertinggi dari aktivitas yang dilakukan capung Brachythemis contaminata. Pengamatan perilaku capung Brachythemis contaminata dilakukan di Embung Tambakboyo menggunakan teknik sampling ad libitum dan focal sampling pada waktu aktif capung, yaitu rentang pukul 09:00 sampai 15:00 WIB. Dari hasil pengamatan didapatkan hasil bahwa terdapat empat kategori perilaku yang ditemukan yaitu inactive (tidak aktif), active (aktif), food related (makan), dan mating (perilaku kawin). Perilaku dengan frekuensi terlama yang diamati dengan teknik Ad Libitum adalah Obelisk perching. Sedangkan perilaku dengan frekuensi terlama yang teramati dengan teknik Focal Sampling adalah Down-Wing perching.
RESPON ANATOMI DAN FISIOLOGI TANAMAN PEGAGAN (Centella asiatica L.Urban) TERHADAP KETINGGIAN TEMPAT YANG BERBEDA DI KULON PROGO
Authors: Sugiyarto Lili , Pradita Deviayu Fajar
Published: September 2024

Penelitian ini bertujuan untuk mengetahui respon anatomi, fisiologi tanaman pegagan (Centella asiatica L. Urban) terhadap ketinggian tempat yang berbeda di Kulon Progo dan faktor lingkungan yang mempengaruhinya.Penelitian observasi dengan metode purposive samplingini dilakukan di tiga tempat dengan ketinggian 0-400 mdpl, 400-800 mdpl dan 0-800 mdpl. Sampel penelitian ini adalah daun pegagan ke 3-4 dengan ukuran yang relatif sama dengan 3 kali ulangan setiap lokasi. Variabel yang diamati berupa penampang melintang daun, kerapatan stomata, kandungan klorofil (total, a, dan b) dan laju transpirasi pegagan serta faktor lingkungan(mikroklimatik dan edafik). Analisis data menggunakan IBM SPSS 26 dengan teknik varian satu jalur, uji lanjut dengan HSD Tukey, dan analisis korelasi, dan regresi. Hasil penelitian menunjukkan bahwa semakin tinggi lokasi maka kerapatan sel pada jaringan palisade dan bunga karang (daun menipis), kerapatan stomata adaksial berkurang, kandungan klorofil (total, a, dan b) bertambah. Laju transpirasi pegagan tidak berbeda pada ketiga lokasi. Faktor lingkungan yang berpengaruh secaa signifikan adalah intensitas cahaya, suhu udara, kelembaban tanah, suhu tanah, kelembaban udara, pH dan kecepatan angin.
PENGARUH PENGELOLAAN SAMPAH DI TEMPAT PEMROSESAN AKHIR PIYUNGAN, KABUPATEN BANTUL TERHADAP KUALITAS UDARA DAN TANAH DI SEKITARNYA
Authors: Mayangsari Maharani Andita , Suhartini Suhartini
Published: September 2024

Tujuan penelitian ini adalah untuk mengidentifikasi cara operasional pengelolaan sampah di Tempat Pemrosesan Akhir (TPA) Piyungan dan mengidentifikasi dampak pengelolaan sampah di TPA Piyungan terhadap kualitas udara dan tanah di sekitarnya. Penelitian ini merupakan jenis penelitian deskriptif kuantitatif. Penelitian dilakukan di Tempat Pemrosesan Akhir Piyungan, Kabupaten Bantul dan sampel diujikan di laboratorium Balai Besar Teknik Kesehatan Lingkungan dan Pengendalian Penyakit (BBTKLPP) Yogyakarta dan Balai Pengkajian Teknologi Pertanian (BPTP) Yogyakarta. Analisis data yang digunakan dalam penelitian ini adalah analisis pencocokan (matching) dan analisis deskriptif. Analisis pencocokan dilakukan terhadap hasil pengujian sampel udara dan tanah dengan baku mutu yang berlaku. Analisis deskriptif digunakan untuk menjelaskan dan menginterpretasikan hasil uji laboratorium kualitas udara dan tanah dengan baku mutu standar, apakah terdapat pengaruh dari pengelolaan sampah terhadap kualitas udara dan tanah di sekitar TPA Piyungan. Hasil penelitian menunjukkan bahwa: (1) Operasional pengelolaan sampah di TPA Regional Piyungan meliputi pencatatan truk masuk, penimbangan sampah, penurunan sampah, penimbunan sampah, perataan sampah, pemadatan sampah, dan penimbunan dengan tanah penutup; (2) Pengelolaan sampah di TPA Regional Piyungan yang menggunakan metode sanitary landfill berpengaruh terhadap kualitas udara dan tanah di lingkungan sekitarnya, namun pengaruhnya masih berada di bawah baku mutu yang diperbolehkan.
Radiation dermatitis: modern approaches to treatment. Review
Authors:   Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Popova N.R. , Sorokina S.S. ,   Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences
Published: September 2024

It is now well established that radiation-induced dermatitis is a complication in 85-95% of patients undergoing standard radiotherapy. Despite the fact that the pathogenesis of radiation dermatitis has been quite well studied, the factors influencing the severity of its course have been established, and its distinctive features compared to thermal and chemical burns have been demonstrated, the prevention and treatment of radiation dermatitis remains an unsolved problem, leading to a decrease in the quality of life of patients and various long-term complications. Today, hygienic procedures are recommended as preventive measures in clinical medicine, namely: daily keeping the skin clean, applying moisturizer, wearing clothes made of soft fabrics, avoiding temperature changes, and protecting from direct sunlight. In addition, a number of products are used to treat other forms of skin lesions – moisturizing and anti-inflammatory ointments and dressings. These procedures help to partially improve the patient’s quality of life; however, they do not have a therapeutic effect on the primary cellular and molecular causes of the development of radiation dermatitis. Currently, there are several potentially more effective treatment methods, such as targeted gene and cell therapy, bioactivators, a number of physical methods and nanocomposites. In our work, we considered modern achievements in the field of treatment of radiation dermatitis, paying special attention to the prospects for the use of nanobiotechnological drugs in connection with their extensive research for science and medicine.
Analisis Kelayakan Usaha Kesehatan Sekolah (UKS) Di Kabupaten Cirebon
Authors: Fatimah Mila , Alif Muhammad Nur , Mulyanto Respaty
Published: September 2024

Usaha Kesehatan Sekolah sebagai upaya pembinaan dan pengembangan pola hidup sehat di sekolah sangatlah penting untuk dijalankan dalam sebuah satuan pendidikan. Hal ini dikarenakan dengan pembinaan dan pengembangan yang tepat, akan menciptakan kesadaran dan berkehidupan yang sehat, khususnya untuk masyarakat satuan pendidikan. Penelitian ini bertujuan untuk mengetahui kelayakan yang telah dicapai oleh Usaha Kesehatan Sekolah sesuai dengan stratifikasi Usaha Kesehatan Sekolah menurut Kementerian Pendidikan dan Kebudayaan Republik Indonesia (Tim Direktorat Sekolah Dasar, 2020). Metode penelitian ini menggunakan jenis kuantitatif dengan metode survei. Penelitian dilakukan dengan cara mengambil data dari kuesioner yang diisi oleh koordinator UKS atau yang memiliki kredibilitas di setiap sekolah. Lokasi penelitian bertempat di Kabupaten Cirebon. Sampel penelitian ini diambil dari 10 sekolah dasar di 10 kecamatan yang berbeda. Untuk pemilihan sampel tersebut digunakan teknik random sampling. Hasil uji t dengan nilai signifikan (2 tailed) yang diperoleh adalah 0,000. Maka nilai signifikan (2 tailed) 0,000 < 0,05 Ha diterima. Sehingga ini menunjukkan bahwasannya terdapat perbedaan klasifikasi terhadap indikator UKS. Hasil dari pengolahan data yang dilakukan dapat disimpulkan bahwa terdapat 67,50% sekolah yang memenuhi penilaian pada indikator Pendidikan Kesehatan, 80% sekolah yang memenuhi penilaian pada indikator Pelayanan Kesehatan, 42,50% sekolah memenuhi penilaian pada indikator Pembinaan Lingkungan Sehat, dan 32,50% pada indikator Manajemen UKS. Sebagai hasil rangkuman dari penilaian empat indikator tersebut didapatkan 55,6% sekolah memenuhi standar kelayakan UKS di Kabupaten Cirebon. Hasil penelitian diharapkan menjadi tolak ukur yang berarti demi terpenuhinya Usaha Kesehatan Sekolah yang ideal di Kabupaten Cirebon.

Kata Kunci: Analisis, Usaha Kesehatan Sekolah, Kabupaten Cirebon.
The Digitalization of Social Care in England and Implications for Older, Unpaid Carers: Constructionist Thematic Analysis
Authors: Rousaki Anastasia , Zamani Efpraxia D , Sbaffi Laura , Hamblin Kate , Black Rachael
Published: September 2024

Background

Globally, populations are aging, generating concerns about the sustainability of health and social care provision. In terms of the public provision of social care in particular, unpaid carers provide much of the support to people with disabilities and older people. In addition, there is an increased onus in many countries on digital transformation projects, in the hope that the digitalization of services can create efficiencies and savings in both costs and care labor. In England, the focus of this paper, the shift to digital services is also framed as a means to enhance choice and control for older unpaid carers, while being part of a broader offering that includes nondigital alternatives and support to mitigate digital exclusion.

Objective

This study examines the impact of digitalization on older, unpaid carers—a group more likely to be both expected to engage digitally with services and at risk of digital exclusion—in England, focusing on their lived experiences in terms of caring and access to social care.

Methods

We used a constructionist approach to thematic analysis, where data from 48 older unpaid carers collected through focus groups were analyzed using thematic analysis, resulting in 4 prevailing themes.

Results

Our findings indicated that while unpaid carers largely acknowledge the benefits of digitalization, they also highlight several points of failure, whereby engagement with digital spaces is experienced as coercive and exacerbates feelings of exclusion. These are further worsened by government failures to address issues of connectivity, imposing additional financial burdens and complicating tasks such as benefit applications.

Conclusions

In this study, we have highlighted the need for greater involvement in shaping both policy and technological solutions, which in turn will be more inclusive and aligned to the aspirations and circumstances of older carers.
Assessment of Neutrophil Lymphocyte ratio, Platelet Lymphocyte Ratio and Albuminuria in Type 2 Diabetes Mellitus – a reliable predictive marker in a resource-limited country: Observational Case-control study (Preprint)
Authors: Kodate Purnima Madhusudanrao , Singh Varsha Abhay , Haldkar Sourav , Turankar Avinash , Pandit Sukant
Published: September 2024

BACKGROUND

Diabetic nephropathy is a common microangiopathic complication in patients with Diabetes Mellitus (DM) leading to End Stage Renal Disease. Inflammation and albuminuria have a crucial place in the development and progression of nephropathy in type 2 DM.

OBJECTIVE

This study aims to know the association of inflammatory markers such as Neutrophil Lymphocyte ratio (NLR) and Platelet Lymphocyte ratio (PLR) with progressive albuminuria in type 2 DM.

METHODS

A total of 110 patients were studied all diagnosed cases of type 2 DM and were divided into three subgroups based on urinary albumin levels: Group I - type 2 DM with Normoalbuminuria; Group II - type 2 DM with Microalbuminuria; Group III - type 2 DM with Macroalbuminuria. Levels of inflammatory markers (NLR and PLR) were recorded and compared in these subgroups.

RESULTS

Significant differences were detected between the groups in terms of NLR (p=0.000) and PLR (p=0.000). Multiple Logistic Regression Analysis showed NLR is significantly influenced by Haemoglobin in g/dL (p=0.001) and Microalbuminuria (p=0.001). Multiple Logistic Regression Analysis also showed Haemoglobin significantly influences PLR in g/dL (p=0.001) and Microalbuminuria (p=0.004).

CONCLUSIONS

NLR and PLR were significantly increased in parallel to albuminuria levels. Therefore, NLR and PLR may serve as a cost-effective and readily accessible marker of Diabetic Nephropathy.
Tic disorders in children in the outpatient practice of a medical psychologist
Authors: Mysiura O.M. , Khaitovych M.V. , Anoprienko O.V. , Sova V.A.
Published: September 2024

Background. The war in Ukraine is a factor of the psycho-emotional trauma in children. As you know, transient motor tics can be observed in almost 20 % of children in the world. Chronic tic and Tourette’s syndrome are also considered common among children. The purpose is to establish the prevalence of tic disorders among children who consult a medical psychologist, ta­king into account gender and age, to determine the directions of therapy. Materials and methods. The study was conducted from March 2023 to March 2024. Three hundred and five children (168 boys and 137 girls) aged 2 to 17 years were examined, who initially consulted a psychologist at the consultative diagnostic polyclinic of the National Specialized Children’s Hospital OHMATDYT. Results. Tic disorders were found in 31 (10.2 %) children: 15 (10.9 %) girls and 16 (9.5 %) boys. Girls with tics were significantly younger than boys with tics and girls from the comparison group. Chronic tic without vocalization was detected in 20 children, tic cough — in 5, vocal tics — in 3, Tourette’s syndrome in 3 cases (girls aged 8–10). Attention was drawn to the pronounced anxiety of the children, which manifested itself particularly in the subjects of their drawings. None of the children showed signs of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection or pediatric acute-onset neuropsychiatric syndrome. The therapy included educational interventions and cognitive behavioral therapy. Conclusions. Every tenth child, who initially consults a medical psychologist, suffered from tic disorder, which required educational activities and cognitive behavioral therapy.
Stability and boundedness criteria for certain second-order nonlinear neutral stochastic functional differential equations
Authors: Ademola Adeleke Timothy , Wen Shiping , Feng Yuming , Zhang Wei , Rutkowski Leszek
Published: September 2024

This paper presents stochastic stability and stochastic boundedness to certain second-order nonlinear neutral stochastic differential equations. The second-order differential equation is weakened to a neutral stochastic system of first-order equations and used together with a second-order quadratic function to obtain perfect Lyapunov-Krasovskii functional. This functional is adapted and applied to obtain criteria on the nonlinear functions to ensure novel results on stochastic stability and stochastic asymptotic stability of the zero solution. Furthermore, when the forcing term is nonzero, fresh results on stochastic boundedness and uniform stochastic boundedness of solutions are obtained. The results of this paper are original, new, essentially improving, complementing, and simplifying several related ones in the literature. Two special cases of the theoretical results are supplied to demonstrate the applicability of the hypothetical results.