bluuebunny/crossref_metadata_2025 huggingface dataset:
La pisciculture intensive en enclos dans les grandes lagunes du Sud-Est Bénin
Authors: Morissens Pierre , Roche P. , Aglinglo C.
Published: February 2025

Le Bénin (112 600 km2, 4 millions d'habitants, 30 000 tonnes de poissons consommés par an) souffre de la dégradation des conditions d'approvisionnement en poissons de sa population. Le développement de l'élevage de poissons dans les lagunes est l'une des techniques actuellement étudiées pour trouver une solution à ce problème. Un projet cofinancé par le Bénin et le Fonds européen de développement, avec l'aide technique de la CTFT, vise à promouvoir l'élevage intensif de poissons dans des zones fermées des principales lagunes du sud-est du pays. Cet article décrit les actions du projet dans le contexte général de la pisciculture en lagune en Afrique de l'Ouest et esquisse les perspectives d'avenir de cette activité.
Profession : importateur de bois tropicaux. Une activité en mutation dans un marché en régression
Authors: Schirmer Isabelle , Febvre François
Published: February 2025

À partir d'une enquête menée en France auprès de 40 importateurs de bois tropicaux, les auteurs ont synthétisé les données recueillies, ce qui leur a permis de mieux comprendre le fonctionnement général du marché et du commerce.Le marché est en baisse, l'offre instable comme le montre l'enquête menée conjointement avec la première, afin de mieux connaître les caractéristiques actuelles de l'offre et leurs répercussions.L'étude indique également que l'importation est une activité en mutation, en raison des années difficiles qui l'ont précédée. Les nouvelles orientations montrent deux tendances : 1) soit la recherche de marges plus élevées (marges de vente grâce au positionnement sur des marchés spécifiques, ou grâce à l'intégration en amont et/ou en aval) ; 2) soit l'augmentation du volume des échanges, ce qui implique des bases financières solides.
Community Empowerment In Applying The Sunnah Of The Prophet: Dhikr To Reduce Anxiety During The Covid-19 Pandemic
Authors: Diyanah Syolihan Rinjani Putri  , Dewi Suryandari
Published: February 2025

The trigger for anxiety in the community during the COVID-19 pandemic was stress due to social isolation or physical distancing during Large-Scale Social Restrictions (PSBB). Excessive anxiety during quarantine can increase the risk of anxiety, depression, and post-traumatic stress symptoms. One way to deal with anxiety problems during the Covid-19 pandemic is to use a non-pharmacological approach, namely the application of the Sunnah of the Prophet: Dhikr is one form of activity or activity that has been exemplified by the Prophet Muhammad. The purpose of this community service is to reduce the anxiety of the Muslim community at the Wonolapan Posyandu. The method of implementing this community service uses the lecture method and leaflet media. Community service will be held at the Pucangan Kartasura Posyandu on Sunday, 27 June 2021. The community at the end of the activity was able to explain simply the meaning of the Sunnah of the Prophet, the purpose of the Sunnah of the Prophet, whenever he performs the Sunnah of the Prophet, stages of dhikr in the Sunnah of the Apostle (100%), the percentage of community activity in counseling the Sunnah of the Apostle: Dhikr is (95%). This shows that the implementation of counseling can increase public knowledge about the management of anxiety during the COVID-19 pandemic.
INNOVATING TOURISM SERVICES: A KNOWLEDGE-BASED APPROACH TO IT INTEGRATION AND EXTERNAL COLLABORATION
Authors:   Assistant Professor, Overseas Chinese University, Taichung City, Taiwan. (R.O.C)., Chang Kuang Yu , Lin Chen-Hsien ,   Associate Professor, National Taichung University of Science and Technology, Taichung City, Taiwan. (R.O.C)
Published: February 2025

This study investigates the interplay between knowledge capabilities, dynamic capabilities, and service innovation within the travel agency sector. Specifically, it examines how knowledge aggregation and transformation contribute to the development of integrative dynamic capabilities and how these capabilities drive service innovation. The study further explores the moderating roles of IT integration capability and knowledge desorption, offering a nuanced understanding of their influence on the relationships between knowledge capabilities and service innovation. Grounded in the knowledge-based view (KBV) and dynamic capabilities theory (DCT), this research seeks to address existing gaps by constructing a comprehensive service innovation framework tailored to the travel industry. Empirical data were collected through a structured survey of travel agency managers, yielding 431 valid responses. Partial least squares structural equation modeling (PLS-SEM) was employed to validate the proposed model and test the hypothesized relationships. The results confirm that knowledge aggregation and transformation significantly enhance integrative dynamic capabilities, including both internal and external integration capabilities. Internal integrative capabilities, in particular, exhibit a direct and positive effect on service innovation, highlighting the critical role of internal coordination and resource alignment. Moreover, IT integration capability and knowledge desorption were found to moderate these relationships, emphasizing their strategic importance in leveraging knowledge for innovation. The findings provide valuable theoretical contributions by enriching KBV and DCT, offering insights into the mechanisms through which knowledge facilitates service innovation. Additionally, this study offers practical recommendations for travel agencies, emphasizing the importance of investing in IT systems and fostering knowledge-sharing practices with external partners to enhance service innovation outcomes. By linking knowledge and dynamic capabilities to service innovation, this research offers a robust foundation for improving organizational competitiveness in the dynamic tourism market.
Solusi Persamaan Schrodinger Tidak Bergantung Waktu Dengan Metode Finite Difference
Authors: Widagda I Gusti Agung , Artawan I Nengah , Suharta Wayan Gede , Antha Kasmawan I Gde
Published: February 2025

The solution of time-independent Schrodinger equation (TISE) has been studied by several researchers. In this research, a TISE solution is found by using the finite difference method which is implemented in computer program code by using the Python language. TISE in the form of a second order differential equation is solved by using the finite difference method. In order to normalize the resulting wave function it is necessary to divide it by square root of the integral of the squared wave function. The integral method used is the Riemann method. In order to prove quantitatively that the TISE solution of the finite difference method is the same as or close to that of the analytical method, it is carried out by using linear regression and the z test. The research results show that the linear regression results from the two methods are nearly close. This is able to be seen from the values of  gradient (m), intercept (c) and coefficient of determination (R2) which are close to ideal values, namely, 1, 0 and 1, respectively. In addition, from the z test it is concluded that the null hypothesis H0 is accepted, which means the solution of finite difference method is equal to analytical solution by a confidence level of 95 percent.
Determination of Radiation Dose Rate and Dose Analysis of Radiation Workers in Radiology Installation at Pariaman Hospital
Authors: Fardela Ramacos , Andriati Susi , Irka Feriska Handayani , Mousa Almahdi , Wahyuni Ade
Published: February 2025

Diagnostic radiology is the most significant contributor to irradiation in the general population. Unnecessary irradiation of workers, patients, and the public during radiological procedures should be significantly reduced without affecting the medical diagnostic value. This study was conducted to analyze and evaluate the radiation dose rate, radiation protection facilities and radiation worker dose of Radiology Installation of Pariaman Regional Hospital. The method of determining the radiation dose rate at the Radiology Instalansi of Pariaman Hospital uses a PDR 303 gamma surveymeter and the rooms to be measured are CT-Scan rooms, conventional X-rays and mammography. Collecting data on radiation protection facilities, then it will be analyzed based on Nuclear Energy Regulatory Agency Regulation No. 4 of 2020 and radiation worker dose data in 2023 will be analyzed based on Nuclear Energy Regulatory Agency Regulation No. 4 of 2013. The results of the study showed that the radiation dose rate around the CT-Scan room was found to be (0.24-1.61) μSv/hour, the conventional X-ray room with irradiation using the minimum exposure factor obtained a radiation dose rate around the room ranging from (0.013-0.33) μSv/hour and with the maximum exposure factor obtained a dose rate around the room of (0.33-1.08) μSv/hour and the mammography room obtained a radiation dose rate of (0.03-0.40) μSv/hour. The radiology room facilities used by Pariaman Hospital are in accordance with the standards set by Nuclear Energy Regulatory Agency Regulation No. 4 of 2020. And the dose rate received by radiation workers at Pariaman Hospital is below the Dose Limit Value set by Nuclear Energy Regulatory Agency Regulation No. 4 of 2013. Based on the results of this study, it is found that there are several measurement points in the CT-Scan and conventional X-ray rooms that exceed the community dose limit value.
Linking anthropometric indices with components of metabolic syndrome among Nigerian adolescents
Authors: Holdbrooke Susan J. , Afolabi Bamgboye M. , Onabanjo Oluseye O. , Salau Islamiat O. , Lucas Olayinka T.
Published: February 2025

Objective: This study aims to evaluate independent and combined association of body mass index (BMI)-for-age percentile (pctl) and waist circumference (WC) with components of metabolic syndrome (MetS) among Nigerian adolescents. Materials and methods: Cross-sectional data of biochemical and anthropometric indices were collected. Each subject was assessed for abnormal WC, elevated blood pressure (BP), diabetic fasting plasma glucose (FPG) level, and high levels of total cholesterol (T-Chol), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), and low levels of high-density lipoprotein-cholesterol (HDL-C). Correlation and linear regression analyses were used to clarify the association between BMI-for-age pctl and WC in relation to the variables of MetS. Receiver operating characteristic curve was used to determine the diagnostic ability and optimal threshold of BMI-for-age pctl and WC for MetS and its components. The area under the curve (AUC) differences between BMI-for-age pctl and WC and components of MetS were compared. Results: Totally 624 adolescents were included in the analysis, of whom 52 (8.3%) met the criteria for MetS. Both BMI-for-age pctl and WC had equivalent ability to predict MetS with AUCs of 0.6847 (p-value < 0.0001) and 0.6479 (p-value < 0.0001) for BMI-for-age pctl and WC, respectively. Conclusions: Both BMI-for-age pctl and WC were effective screening tools to diagnose MetS. BMI-for-age pctl seemed a better predictor of MetS than WC in our study sample of predominantly Nigerian adolescents living in an urban area. Both BMI-for-age pctl and WC can be easily measured and are cost effective. Their application for predicting MetS among Nigerian adolescents has vital clinical utility.
Pregnancy and Childbearing for Orthopaedic Surgeons
Authors: Cristofaro Caroline , Bouchard Maryse
Published: February 2025

While female representation within surgical specialties is increasing, the field of orthopaedic surgery remains male-dominated. Residency, fellowship, and early career coincide with the childbearing years of female surgeons. Given the overlap between these critical career stages and years of childbearing, there has been a rise in articles characterizing the experiences and perceptions around childbearing and its impact on surgeons and their careers. Multiple studies have reported the alarmingly high rates of pregnancy complications, infertility, pregnancy loss, voluntary delay in childbearing, and postpartum depression in surgeons, including those in the field of orthopaedic surgery. However, perinatal complications are not the only barriers female orthopaedic surgeons may face should they decide to start a family alongside their career. Negative perceptions and lack of support from their colleagues and institutions have also been reported as commonplace. Limited but successful support programs, policies, and resources that are designed to support female surgeons and their partners have been created in North America. Successful support programs can be used to inspire institutional policies across North America to hopefully improve the pregnancy and childbirth experiences of orthopaedic surgeons.
Competition Law Paradigm in the Majapahit Constitution
Authors: Faizal Bhismoadi Tri Wahyu , Amin Muhammad , Sidiq Muhammad Aunurrofiq , Nurmawati Reni Prasetia
Published: February 2025

This paper aims to map and analyze business activities potentially resulting in monopolistic practices and unfair business competition in the Majapahit kingdom. This research also attempts to figure out how the rule of law was applied during the Majaphit kingdom to curb monopolistic business activities. This research applied a qualitative design with normative legal or library research that relies on secondary data sources. Primary legal materials in this research are two ancient books by Slamet Muljana, namely Majapahit Legislation and Nagarakretagama Historical Interpretation; secondary legal materials are books and journals related to this research. The results show that 4 (four) types of activities can lead to monopolistic practices and unfair business competition, namely, destroying or burning agricultural land, reducing farm yields, refusing others to do the same business and controlling land owned by small farmers by large farmers. For these activities, the Majapahit royal government imposed the rule of law contained in Articles 260 - 262 of the Kutaramanawa and Article 88 paragraph (3) of the Nagarakretagama which includes a prohibition on burning and destroying agricultural land, a ban on reducing agricultural yields by narrowing the land or leaving the land abandoned, a prohibition on refusing others to work on the land, and a prohibition on large farmers to control the land of small farmers. The government in the Majapahit era demonstrated how the law should be implemented, and that it should be emulated by modern countries, including Indonesia, to enforce the country’s welfare by encouraging vigorous and competitive law in Indonesia.
Political Dynasties in General Elections According to Human Rights and A Comparison in Four ASEAN Countries
Authors: Saifulloh Putra Perdana Ahmad , Barus Sonia Ivana , Nggilu Novendri M , Nur Asrul Ibrahim , Sulaiman Dindha Shahrazade
Published: February 2025

The advantages of this article are discussing the Prohibition of Dynastic Politics from a Human Rights Perspective and Legal Formulas to Minimize Dynastic Politics as well as comparisons in three ASEAN countries. The research results concluded that the practice of dynastic politics cannot be separated from a human rights perspective, especially political rights for citizens. However, on the other hand, if it continues, the practice of dynastic politics can damage democratic principles. This is also based on comparisons in Singapore, Thailand and the Philippines. For this reason, in this article, the author provides a legal formula to minimize the negative excesses of dynastic politics, namely by strengthening the conditions for presidential/vice presidential candidates, gubernatorial candidates, mayoral candidates, and regent candidates in internal political parties. So that political parties will also strengthen the party system so as to avoid collusion and nepotism. To minimize dynastic politics, it is necessary to improve the culture within political parties. The reconstruction of the design of a democratic presidential candidacy is to prioritize the process of deliberation and consensus. Through the formation of the Party Consultative Assembly, it is hoped that it will be able to overcome and interpret the ideological ideals of political parties and the ideals of political leadership. This needs to be regulated in the Memorandum of Association/Articles of Association of Political Parties and the revision of the Political Party Law and Election Law. Furthermore, the analysis used normative legal research, including statutory, comparative, and conceptual methods.
Reinterpretasi Pendidikan Moderat dalam Tafsir Al-Muntakhabat Karya KH. Achmad Asrori Al-Ishaqi dan Penerapannya dalam Sistem Pendidikan di Indonesia
Authors: Ridho Muh Makhrus Ali , Mumtahana Lusia
Published: February 2025

The increasingly complex challenges of radicalism and intolerance, including in Indonesia, make it necessary to explore the understandings of previous ulama' so that they can give birth to a comprehensive understanding of moderate education, including understanding in contemporary Sufi interpretations, especially through the work of KH. Achmad Asrori al-Ishaqi, who is a recognized figure in the world of Islamic scholarship. The aim of this research is to explore new understandings about religious moderation education in the context of contemporary Sufi interpretation. The urgency of this research is to prevent the spread of religious extremism ideas that are spread through educational channels. This research method includes text analysis of the Sufi Tafsir al-Muntakhabat, with a focus on the concepts of religious moderation education contained in the work. Analysis is carried out in depth to understand how these concepts are interpreted and applied in today's context. The results obtained in this research are that there are four moderate educational values ​​in the Sufi commentary book al-Muntakhabāt by KH. Achmad Asrori al-Ishaqi include: First, justice ('is), second, wasaṭiyah (middle), third, strengthening brotherhood between fellow humans (tolerance), fourth, respect for differences. Looking at some of these moderate educational values, when implemented in the curriculum they will be an important contribution to efforts to prevent radicalism and extremism as well as building a more harmonious society
عادت أولي العزم من الرسل في حياتهم الاجتماعي من خلال القرآن والسنة
Authors: Ananda Fadhli , Gasmelsid Saadeldin Mansour , Ahmed Ali Ahmad El-Mogtaba Bannga
Published: February 2025

The Messengers of Ūlū al-‘Azm were distinguished Prophets who held high positions and exerted significant influence in their societies. they shared similar Practices and approaches in addressing challenges in their social lives. Their determination and patience in improving the community is seen in the Qur'an and Sunnah. So this research seeks to uncover the habits of Ūlū alĀzm in their social life and reveal the meanings contained therein based on the verses of the Qur'an and Hadith. This research uses the descriptive method of analysis to look at the habits in social life experienced by the Ūlū alĀzmi prophets. Among the conclusions of this study is that the Apostle Ūlū alĀzm both have noble morals, because the Apostle Ūlū alĀzm applies social values that are guided by Allah Ta'ala, as for the differences in times and social conditions experienced by the Apostle Ūlū alĀzm are different but if there are causes and characteristics that are repeated they will use the same approach in improving and restoring social values in their society, because all social values and the ultimate criteria for good and bad social behavior are rooted in divine revelation.
Overview of The Firdaws Al-Na'īm: Bridging Classical Tradition of Tafsīr and Madura’s Local Context
Authors: Agustono Ihwan , Badrun Muahammad , Halida Putri Alfia
Published: February 2025

Penelitian ini mengkaji metode Tafsīr Firdaws al-Na'īm karya KH. Thoifur Ali Wafa, yang memiliki kontribusi signifikan dalam perkembangan kajian tafsīr kontemporer di Indonesia. Karya ini mengintegrasikan tradisi tafsīr klasik dengan pendekatan kontekstual yang lebih relevan dengan isu sosial dan budaya lokal, khususnya di Madura. Fokus utama penelitian ini adalah untuk menganalisis bagaimana Tafsīr Firdaws al-Na'īm menggabungkan penafsiran teks al-Qur’ān dengan nilai-nilai budaya Madura, serta kontribusinya dalam menjawab tantangan kehidupan modern umat Islam di Indonesia. Melalui pendekatan kualitatif berbasis studi kepustakaan, penelitian ini mencoba membandingkan Firdaws al-Na'īm dengan sejumlah kitab tafsīr klasik lain, seperti: Tafsīr al-Qhurtūbī, al-Nasafī, al-Jalālayn, dan Mafātih al-Ghayb. Hasil penelitian menunjukkan bahwa Firdaws al-Na'īm menawarkan sebuah penafsiran al-Qur’ān yang tidak hanya bersifat teoritis, tetapi juga aplikatif, dengan memperhatikan konteks sosial dan budaya. Penelitian ini diharapkan mampu semakin memperkaya khazanah studi tafsīr di Indonesia, serta dapat memberikan perspektif baru yang relevan untuk kehidupan umat Islam masa kini.
Síntomas emocionales y estado funcional en pacientes post-COVID-19 en hospital mexicano especializado
Authors: Pech Arguelles Roberto Carlos , Guillermo Herrera Jorge Carlos , Ramos-Xochihua Larissa M , Curiel Silva Jose Luis , Rangel Sosa Emmanuel , Poot Lopez Irene Josefina , Martinez Hernandez Rafael , Cambranes Catzim Roberto A , Vargas Echeverría Shilia Lisset
Published: February 2025

Theoretical framework: Information on the prevalence of post-COVID-19 symptoms and their impact on functional status is variable. Objective: To characterize persistent symptoms, depressive symptoms, and the functional status of post-COVID-19 patients. Method: Observational, cross-sectional, and descriptive study. Instruments were applied via telephone (4-25 weeks post-discharge): Cross-cultural adaptation of the C19-YRS Questionnaire, Post COVID-19 Functional Status Scale, and CES-D. Results: Hypertension was the most frequent comorbidity; persistence of pain (66.6%) and fatigue (66%) related to the disease were the most common symptoms, followed by post-traumatic stress disorders, anxiety, depression, and dyspnea. 100% of the patients showed alterations in their functional status and their global perception of health after COVID-19. A low percentage of post-COVID-19 depression diagnoses was identified according to the CES-D scale. While the C19-YRS questionnaire was able to identify patients who presented depression through the CES-D scale, it showed a high frequency of false positives. Conclusions: COVID-19 has physical, psychological, and social consequences on patients, making rehabilitation measures for survivors necessary. These measures should be directed by a multidisciplinary team of specialists with long-term planning.
WITHDRAWN: Land cover changes based on open spatial data - a case study
Authors: Głogowska Magdalena
Published: February 2025

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Proposal of an Ultrasonographic Classification of Tibial Bone Healing Image Patterns
Authors: gaiarsa guilherme pelosini , Reis paulo roberto dos , Silva Jorge dos Santos , Kojima Kodi Edson , de Camargo Olavo Pires
Published: February 2025

Purpose: To describe the image patterns related to POCUS evaluation of tibial fracture healing and delayed healing.
Methods: Between August 2020 and December 2023, patients with tibial fractures treated with intramedullary nails were evaluated monthly using ultrasonographic and radiographic evaluations and documentation. Ultrasonographic image patterns are described.
Results: Six different frequent patterns were found: (1) disorganized cotton-like image at the fracture line, (2) small bump with bridging callus in lower-energy trauma, (3) bridging callus with displaced cortical fragment, (4) larger callus with mountain formation, either continuous or with a lip-like image, (5) mushroom-like bridging callus with height greater than length, and (6) V-shaped image with irregular borders and corkscrew signal, indicating nonunion.
Conclusion: Imaging patterns can help to understand the healing process and guide future research on bone healing. Knowledge of the early stage of bone healing can influence decision making in delayed union and nonunion treatment.
Aberrant expression of human endogenous retroviruses and SETDB1 in adolescents with anorexia nervosa
Authors: Amianto Federico , Tovo Pier Angelo , Po Alice , Calvi Cristina , Davico Chiara , Montanari Paola , Rainò Elena , Anichini Antonella , Vesco Serena , Bechis Daniela , Marottra Cristina , Galliano Ilaria , Gambarino Stefano , Bergallo Massimiliano
Published: February 2025

Human endogenous retroviruses (HERVs) represent 8% of the human genome. They are remnants of ancient infections of germinal cells. HERVs are no longer infectious, but some retroviral sequences can be activated and their enhanced expressions have been implicated in a number of diseases, including neuropsychiatric disorders. HERV transcription is regulated by TRIM28 and SETDB1, which are directly involved in the regulation of epigenetic processes, in neural cell differentiation, and brain inflammation. HERVs and TRIM28/SETDB1 expressions have not been investigated in patients affected by anorexia nervosa (AN). We assessed, through a PCR real-time Taqman amplification assay, the transcription levels of pol genes of HERV-H and -K, of env genes of Syncytin 1 (SYN1) and SYN2 as well as of TRIM28 and SETDB1 in whole blood of 37 adolescents with AN and in healthy controls (HC) of comparable age. The transcriptional levels of HERV-H-pol and HERV-K-pol as well as of SETDB1 were significantly higher in AN patients as compared with HC, while no differences were observed for SYN1, SYN2, and TRIM28. Over-expressions of HERVs and of SETDB1 in adolescents with AN suggest that they may be main actors in the pathophysiology of AN and open the way to development of novel therapeutic strategies.
Prevalence, incidence and demographics of dementia in Ecuador
Authors: Figueira José Alejandro Valdevila , Yambay-Bautista Xavier Rodrigo , Parra Indira Dayana Carvajal , Santiestevan Rocio Valdevila , Coronel Andrés Alexis Ramírez , Cárdenas Luis Francisco Altamirano , Cucalón María José Pico , Rodas Jose A
Published: February 2025

Background: This study examines the prevalence and incidence of dementia in Ecuador, with a focus on understanding demographic and social factors associated with increased risk. Data were obtained from the Institute of Neurosciences of Guayaquil, covering patient records from 2010 to 2022. The purpose was to identify prevalence trends and key risk factors to inform targeted prevention and early intervention efforts in high-risk groups.
Methods: This observational, correlational study analysed patient data to estimate dementia prevalence and incidence. Statistical analyses included descriptive statistics to calculate overall and age-specific prevalence rates, while incidence was calculated per 1,000 person-years. Correlations and chi-square analyses were used to evaluate associations between dementia and potential risk factors, including age, gender, education level, and marital status.
Results: The overall prevalence of dementia was 3.1%, with higher rates among women (1.8%) compared to men (1.3%). Dementia incidence was calculated at 2.4 per 1,000 person-years. Prevalence increased significantly with age, from 1.2% in individuals aged 65–69 to 54.8% in those aged 95 and older. Advanced age, female gender, lower education levels, and lack of a marital partner were associated with higher dementia prevalence.
Conclusions: These findings highlight a rising dementia prevalence in Ecuador, particularly among women and older individuals, with social and educational factors contributing to increased risk. The results underscore the need for tailored dementia prevention and early intervention strategies, especially as prevalence rates continue to rise across Latin America.
Overcoming High Reduction Potentials via Consecutive Mechanical-Force-Induced Electron Transfer Strategy
Authors: Lian Zhong , Wang Xiaohong , He Xiaochun , Zhang Xuemei , Wang Qingqing , Huang Qian , Qu Ruiling
Published: February 2025

Mechanical-force-induced redox catalysis has recently advanced rapidly, emerging as a green and innovative tool in synthetic chemistry. The foundation of this strategy lies in the single electron transfer (SET) from polarized piezoelectric materials to the substrates, which is initiated by the piezoelectric potential generated through mechanical agitation. The magnitude of this piezoelectric potential is primarily influenced by the intrinsic properties of the piezoelectric material. In certain circumstances, however, the generated piezoelectric potential may be insufficient to trigger the SET process, akin to the limitations of visible-light excitation in photocatalytic reactions. This challenge has motivated us to explore effective solutions. In this work, we establish a catalytic system that utilizes a consecutive mechanical-force-induced electron transfer (ConMET) strategy. This novel catalytic system employs piezoelectric materials as mechanochemical redox catalysts, with 9-phenyl-dihydroacridine (D1) serving as sacrificial electron donors, facilitating consecutive electron transfer to produce significantly more powerful reductive species during mechanical grinding. Our approach effectively promotes the reduction of aryl iodides, bromides and even electron-rich aryl chlorides, which possess reduction potentials as high as − 2.8 V (vs. SCE), leading to the formation of aryl radicals. Ultimately, this innovative catalytic strategy enables anti-Markovnikov hydroarylation of alkenes and dehalogenative deuteration of aromatic halides (Cl, Br) under mild conditions.
An Artificial Intelligence Model to Detect Abnormal Ejection Fraction from Non-Contrast Chest Computed Tomography: The CT-LVEF study
Authors: Raikhelkar Jayant , Bai Zilong , Beecy Ashley , Liu Fengbei , Nizam Nusrat , Kishore Varsha , Kelsey Chris , vanMaanan David , Ruhl Jeffrey , Tesfuzigta Naomi , Lancet Erica , Leb Jay , Legasto Alan , Elias Pierre , Poterucha Timothy , Kumaraiah Deepa , Wang Fei , Sayer Gabriel , Estrin Deborah , Sabuncu Mert , Uriel Nir
Published: February 2025

Heart failure (HF), a major global health challenge, affects millions worldwide and poses substantial healthcare and economic burdens. The left ventricular ejection fraction (LVEF) is a critical dynamic parameter used to characterize HF and guide treatment. In this study, we developed and validated an artificial intelligence (AI) model capable of predicting abnormal LVEF directly from static, non-gated, non-contrast chest computed tomography (CT) scans, a novel application for an imaging modality typically used for unrelated indications. Using a multi-institutional dataset of 34,058 paired CT and echocardiogram studies from two academic centers, we trained our model on over 25,000 studies and validated it on 8,110 studies from a separate institution. Remarkably, our model demonstrated robust performance, achieving an area under the receiver operating characteristic curve (AUROC) of 0.786 on the hold-out test set and 0.755 on external validation. Our findings are particularly promising given the widespread availability of CT scans—over 80 million performed annually in the U.S.—making this opportunistic screening approach highly practical. Beyond strong predictive performance, the AI model outperformed expert radiologists in both accuracy and efficiency and provided interpretable visualizations highlighting imaging features linked to reduced LVEF. By enabling the identification of HF from routine chest CTs performed for other indications, this technology holds significant promise for early detection, reducing the diagnostic gap, and improving outcomes in asymptomatic HF.
Risky Sexual Behavior and Associated Factors Among Secondary School Students in Mirab Abaya District, Southern Ethiopia, 2024
Authors: Hailegiorgis Yegetaneh , Kondale Mekdes , Gebru Zeleke , Hailegiorgis Eden
Published: February 2025

Introduction: Ethiopia prioritized adolescent and youth health programmes in recent years; particularly in sexual and reproductive health and youth development. Despite these efforts, significant challenges remain, risky sexual behavior among adolescents poses significant public health challenges, including high rates of unintended pregnancies and sexually transmitted infections.
Objective: To assess the magnitude of risky sexual behavior and factors associated with it among secondary school students in Mirab Abaya district, Southern Ethiopia, 2024.
Method: A school-based cross-sectional study was carried out on 389 students selected by simple random sampling method from September 30 to October 14, 2024. The data were collected using a self-administered structured pretested questionnaire and analyzed using the statistical package for social science version 27. Binary logistic regression analysis was employed to identify the associated variables with the outcome variable. Variables found to have a p-value of <0.25 in the bivariable analysis were passed to multivariable analysis.
Result: From 408 students, 389 participated, with a response rate of 95%. The prevalence of risky sexual behavior was 30.10% (95% CI: 25.65%–34.55%). Substance use (AOR = 3.85, 95% CI: 1.44–10.22), watching pornographic movies (AOR = 2.10, 95% CI: 1.64–5.61), neglectful parental monitoring (AOR = 3.71, 95% CI: 1.39–9.86), peer pressure (AOR = 3.46, 95% CI: 1.30–9.88), authoritative parental monitoring (AOR = 0.18, 95% CI: 0.07–0.49). Students’ knowledge (AOR = 2.33, 95% CI: 1.53–6.17) and attitudes (AOR = 2.58, 95% CI: 1.89–6.90) were significantly associated with risky sexual behavior.
Conclusion and recommendation: The magnitude reported here is significant which demand crucial attention. Educational campaigns should be implemented to address the risks associated with substance use. Efforts should be made to improve the availability of condom, parental engagement in discussions regarding sexuality, and establishment of peer-led health clubs within schools to fostering supportive environments and promoting healthier choices among students.
Dielectric Properties of Tin Selenide Nanoparticles
Authors: Gosai N. N. , Solanki G. K.
Published: February 2025

In this paper of chemical precipitation method to prepared SnSe nanoparticles through directly mixed Sodium selenosulfate solution (Na2SeSO3) in selenium chloride solution (SnCl2·2H2O) by drop wise. We investigated the dielectric properties of Tin Selenide (SnSe) nanoparticles obtained by chemical precipitation method in deionized water. Chemical composition of grown powder is studied with the help of EDAX. Dielectric properties of tin selenide nano particles showed strong indication of frequency and temperature dependence of capacitance (C), dielectric constant (K), dielectric loss (tanδ), real and imaginary part of dielectric constant (ε' and ε") over the frequency range 100 Hz to 1M Hz using LCR meter model 4284A and temperature ranges 303 to 523 K. In this investigation, dielectric constant is observed to be high at lower frequency and it systematically decreases with increasing frequency up to 600 kHz and then after it nearly becomes frequency independent while dielectric loss tanδ decreases with temperature and frequency.
A Standardized Nontargeted Metabolomics Analytical Method for Qualitatively Comparing Apples to Apples
Authors: Watkins Steve , Odenkirk Melanie , Michel Cole , Doenges Katrina , Leaptrot Katrina , Sherrod Stacy , May Jody , Read Margaret , Chaparro Jacqueline , Montgomery Nathan , Brinkley Sarah , Vaniya Arpana , Mitchell Susan , Yu Bruce , Elhaderi Jason , Henson Louie , Broeckling Corey , Fiehn Oliver , Reisdorph Richard , Reisdorph Nichole , McLean John , Chien Chi-Ming , Shafizadeh Tracy , Parra John de la , Ahmed Selena , Prenni Jessica
Published: February 2025

Food composition has been traditionally defined by 35-160 chemical components with established nutritional significance for human health. Modern omics technologies have revealed that the chemical complexity of food is far greater, offering the potential to deepen our understanding of food composition to more precisely inform data-driven solutions across food systems. However, challenges in generating comparable omics data have limited the utility of omics technologies at the scale required to expand food composition databases. Herein, we present a standardized nontargeted LC-MS metabolomics method, supported by a novel internal retention time standard (IRTS) mixture of compounds non-endogenous to food that enables robust chromatographic alignment of data across laboratories. Our results demonstrate qualitative consensus of features across laboratories and/or instrumentation. This approach establishes the foundation for comparable, nontargeted omics analysis to support the next generation of food composition data.
Comparative in Vitro Quality Evaluation of Ciprofloxacin Tablets collected from local market
Authors: Nirea Tsega Zeru , Meressa Mengstieab Gebrehiwet , Berhe Gebregziabher Brhane
Published: February 2025

Ciprofloxacin is a versatile antibiotic that fights a wide range of bacteria, both Gram-negative and Gram-positive. This study looked at the quality and consistency of several 500 mg ciprofloxacin tablet brands available in local pharmacies in Tigray. To check weight uniformity, we weighed twenty tablets from each brand. We tested how quickly the tablets break down in water at a temperature of 37 ± 0.5°C. We also ran dissolution tests using a paddle apparatus, measuring how much of the drug dissolved at 276 nm. For the active ingredient analysis, we used High-Pressure Liquid Chromatography (HPLC) with a specific setup: a stainless steel column filled with a special silica gel (Hypersil BDS), UV-VIS detection at 278 nm, a flow rate of 1.5 ml/min, and an oven set at 40°C. The results were impressive. The friability rates (which measure how easily tablets crumble) were between 0.04% and 0.08%, well below the BP standard of less than 1%. The tablets' hardness ranged from 11.45 to 32.43 kgf, meeting the requirement of being above 5 kgf. The tablets disintegrated in 3 to 4.5 minutes, well within the 30-minute limit set by BP and USP-40 standards. Dissolution tests showed that over 80% of the ciprofloxacin was released within 30 minutes, with results between 93.5% and 101.2%. The active ingredient assays, both UV and HPLC, met BP standards. The CP-500 brand had the highest results, with 104.3% by UV and 103.9% by HPLC, all within the acceptable range of 95.0–105.0% (BP) and 90.0–110.0% (USP). Overall, the study confirmed that the ciprofloxacin tablets from different brands in Tigray's local market are of high quality.
Ventricular remodeling with dapagliflozin in elderly women with HFpEF--a single center prospective study
Authors: Huang JiaJia , Xu SuYan , Wang AiFeng , Shi Yanan
Published: February 2025

Purpose To investigate the clinical efficacy and prognosis of dapagliflozin in elderly women with heart failure with preserved ejection fraction (HFpEF). Methods From March 2022 to September 2023, 299 elderly female patients with HFpEF were randomly divided into control group (n = 149) and dapagliflozin group (n = 150) by random number method. Baseline clinical data and laboratory test results were collected. The changes of relevant results before and after treatment in each group were sorted out and compared. After discharge, the enrolled patients were followed up by outpatient or telephone for an average of 12 months, and were followed up for rehospitalization of heart failure, occurrence of ventricular arrhythmia and major adverse cardiovascular events (MACE). Results After anti-heart failure therapy, N-terminal pro-brain natriuretic peptide (NT-proBNP) was detected between the two groups. Soluble growth stimulation expressed gene 2 (ST2), Galectin-3 (Gal-3) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) were statistically significant. NT-proBNP, Gal-3 and MLHFQ in dapagliflozin group were significantly lower than those in control group after treatment (all P < 0.05). After 12 months of treatment in the dapagliflozin group, left ventricular ejection fraction (LVEF), Estimated glomerular filtration rate (eGFR)and Direct Bilirubin (DBil)((all P < 0.05)were significantly higher than those before treatment. After 12 months, c-reactiveprotein (CRP) was significantly lower than that before treatment in the dapagliflozin group. Na levels in dapagliflozin group was significantly increaser. MACE events in dapagliflozin group were significantly decreased (P < 0.05). Conclusion The clinical efficacy and prognosis of elderly female HFpEF patients were significantly improved after treatment with dapagliflozin.
Exploring Research Productivity and Key Trends in African Urban Renewal Studies: A Bibliometric Approach.
Authors: Ossai Onyinyechi , Akukwe Thecla , Mba Chinedu , Ali Alphonsus
Published: February 2025

Urban renewal has emerged as a critical aspect of sustainable urban development, particularly in the context of Africa’s rapidly growing cities. As governments and policymakers strive to address challenges related to urbanization, housing, and infrastructure, research on urban renewal provides valuable insights into effective planning and policy interventions. This study examines the growth patterns, distribution of productivity, research hotspots, and emerging trends in urban renewal scholarship across Africa using bibliometric analysis. A total of 151 publications from the Scopus database were analyzed using R Programming Language. The findings indicate a continuous trajectory of urban renewal research since 1980, with an average annual growth rate of 4.52%, peaking at 12 articles in 2020. South Africa emerges as the leading contributor in terms of both publication volume and citation impact. Urban Forum is identified as the most prominent journal in this field, while the South African Geographical Journal stands out as the most notable indigenous journal. The bibliometric analysis highlights 23 major research trends, predominantly focusing on macro-level challenges, government-driven economic development, sustainable planning, and human-centered policy interventions. Despite these advancements, the study underscores a critical research gap in areas such as informal settlements, urban poverty, and green infrastructure, emphasizing the need for broader and more inclusive urban renewal research across the continent.
Investigating the Role of Stable Flies (Stomoxys calcitrans) and Biting Midges (Culicoides spp.) as Potential Mechanical Vectors of African Swine Fever Virus in Lithuania, Poland and Romania.
Authors: Dhollander Sofie , Balmoș Oana-Maria , Cattaneo Eleonora , Cortiñas José Abrahantes , Boklund Anette Ella , Szczotka-Bochniarz Anna , Mihalca Andrei Daniel , Mur Lina , Frant Maciej , Gal-Cisoń Anna , Kwasnik Malgorzata , Rozek Wojciech , Malakauskas Alvydas , Masiulis Marius , Turcinaviciene Jurga , Chesnoiu Theodora , Jazdzewski Krzysztof , Rola Jerzy , Barbuceanu Florica , Miranda Miguel Ángel , Stegeman Jan Arend
Published: February 2025

Background
Since its emergence in Georgia in 2007, the seasonal pattern of African swine fever virus (ASFV) genotype II outbreaks in European pig populations has been evident. It is hypothesized that summer-related farming practices, along with the increased activity and abundance of arthropod vectors during warmer months, contribute to the increased incidence of these outbreaks during this period. This study investigated the potential role of stable flies (Stomoxys calcitrans) and biting midges (Culicoides spp.) as mechanical vectors of ASFV.
Methods
From August 2021 to August 2023, vector surveillance was conducted as part of a case-control study on 42 outbreak farms and 70 control farms across Romania, Lithuania, and Poland. Collected insect specimens were pooled and tested for ASFV DNA using real-time PCR.
Results
A total of 8,604 biting midges’ specimens and 742 S. calcitrans flies were collected, with ASF DNA detected in 27 out of 1,219 insect pools. Positive pools were predominantly observed in Culicoides punctatus, C. newsteadi, and the Obsoletus complex, with most detections occurring in August. However, ASFV isolation was unsuccessful. Statistical analyses revealed no significant association between farm status (outbreak vs. control) and ASFV DNA detection in biting midges’ pools, likely due to limited sample size. Additionally, two ASFV-positive S. calcitrans pools were identified, supporting their potential role as mechanical vehicles for ASFV. The findings highlight the affinity of C. punctatus, C. newsteadi, and the Obsoletus complex and S. calcitrans for pig farms, which may increase the likelihood of ASFV acquisition and dissemination, assuming viral infectivity is maintained in these insects. Environmental factors, such as pig farm density and proximity to other hosts, likely influence this risk.
Conclusions
These results emphasize the importance of vector control strategies, including insect netting, to mitigate ASFV transmission risks. Further research is needed to understand the dynamics of ASFV infection in arthropods. Notably, this study also reports the first identification of Culicoides riethi and Culicoides salinarius in Lithuania.
A novel metric to monitor early progression in keratoconus: Epithelial backscatter
Authors: Toprak Ibrahim , Gunes Celal Emre , Martin-Seker Cigdem , Parca Osman
Published: February 2025

Purpose
To assess the progression of keratoconus over the course of one-year using epithelia and anterior stromal backscatter, Belin ABCD progression display, and various Pentacam® parameters and to determine whether backscatter measurements can be utilized to monitor progression.
Methods
This single-centre, cross-sectional study evaluated change in epithelial and anterior stromal backscatter (using the line densitometry feature of the Pentacam®) and the flat, steep, mean and maximum keratometry, Belin ABCD progression display, corneal elevations, Belin/Ambrósio enhanced ectasia display (BAD-D), pachymetric progression index (PPI), maximum Ambrósio relational thickness (ARTmax), and topometric indices, between baseline and one-year in 37 eyes (37 patients) with keratoconus.
Results
When compared to the baseline after one-year, epithelial backscatter increased (p < 0.05); posterior radius of curvature, BAD-D, average PPI, index of vertical asymmetry (IVA), and index of height decentration (IHD) worsened (p < 0.05); and the anterior stromal backscatter, keratometry values, Belin ABCD stages, thinnest pachymetry, elevations, and ARTmax remained stable (p > 0.05). There were statistically significant weak-to-moderate correlations between the backscatter values and Pentacam® parameters (p < 0.05).
Conclusion
Epithelial backscatter can be considered a novel parameter to monitor the progression of keratoconus, as it was found to have similar abilities to those of the posterior radius of curvature, BAD-D, average PPI, IVA, and IHD, all of which demonstrated early evolution during one-year of follow-up, while the front keratometric data exhibited no progression. Moreover, by generalizing single-point backscatter data to the entire corneal surface, epithelial backscatter can be integrated into Pentacam® maps as a novel feature in keratoconus diagnosis and progression follow-up.