bluuebunny/crossref_metadata_2025 huggingface dataset:
Food Security Analysis of Shallot Farmer Household During the Covid-19 Pandemic in Probolinggo Regency (A Case Study on Shallot Farmer Household in Mranggonlawang Village, Dringu District, Probolinggo Regency)
Authors: Khasanah Ulfa , Sari Nira , Hanani Nuhfil , Fahriyah Fahriyah , Nugroho Condro , Syafrial Syafrial , Asmara Rosihan
Published: December 2022

The Covid-19 pandemic has had an impact on the agricultural sector, both in terms of trade, prices, and the decline in farmers' income levels. Amid the COVID-19 outbreak, food security is something that the government must pay attention to so that there is no food crisis. If farmer households have not realized food security, it won't be easy to create food security at higher levels such as the village, district, provincial, and national levels. This study aims to analyze food security based on EAR and SFE values ​​and determine the effect of socioeconomic factors on household resilience. Determination of the research location was determined purposively, and the number of samples was taken by cluster sampling. The analytical method uses the Jonnson and Toole model to determine household food security and multiple linear regression analysis to determine the effect of socioeconomic factors on EAR. The results of the food security analysis show that 51.7% of households with energy consumption >80% and expenditure of 60% are categorized as food vulnerable. The results of the analysis of socio-economic factors that can affect EAR are income, number of dependents in the family, length of education of housewives, and age of the head of the family with a confidence level of 80%. The analysis results show that most shallot farming households are in a food-insecure state.
Behavior Therapy in Those Who Are Addicted to Online Games
Authors: Humayya Atin , Windarwati Heni Dwi , Winarni Indah
Published: December 2022

Adolescents addicted to online games harm their physical, psychological, and social health and require therapy. Providing therapy such as behavior therapy can help reduce online game addiction. This research aims to review articles that discuss the addictive behavior of online games and the therapy used. The method used in this study is a literature review by identifying articles from a systematic review identifying articles from four data based on ScienceDirect and PubMed in 2020. Based on the inclusion and exclusion criteria set, using the keywords behavior therapy, adolescents, and online game addiction from 2017-to 2020. We discovered 15 publications that satisfied the inclusion criteria and deserved to be considered in our examination of data-based articles. Adolescents who experience online game addiction discussed they vary in the causes, symptoms, effects, and psychotherapy given. Cognitive Behavioral Therapy (CBT), Social Skill Training (SST), and Mindfulness are all types of behavior therapy that can help kids addicted to online games. Psychotherapy can help teens addicted to internet games.
Perubahan Profil Proteomik Plasmodium falciparum Galur Papua 2300 Akibat Paparan Antimalaria Artemisinin In Vitro
Authors: Maslachah Lilik
Published: December 2022

Perkembangan resistensi Plasmodium falciparum dan penurunan kepekaan parasit terhadap obat antimalaria artemisinin menjadi salah satu permasalahan kesehatan di dunia. Sampai saat ini belum ada obat baru pengganti artemisinin. Penelitian ini bertujuan untuk membuktikan bahwa paparan obat antimalaria artemisinin berulang in vitro dapat menyebabkan perubahan profil protein melalui pendekatan proteomik P. falciparum galur Papua 2300. Waktu penelitian dilaksanakan mulai bulan Pebruari sampai dengan Nopember 2014. Tempat penelitian di Laboratorium Biomedik Fakultas Kedokteran Universitas Brawijaya, Fakultas Kedokteran Hewan Universitas Airlangga. Airlangga Influenza Research Center, Laboratorium bersama Kimia Â Universitas Negeri Surabaya (UNESA) dan jurusan Kimia Politeknik Malang. Desain penelitian yang digunakan adalah Experimental Design dengan Post test only control group design. Kultur P. falciparum galur Papua 2300 dipapar antimalaria artemisinin berulang dengan menggunakan Inhibitory Concentration 50 (IC50). Pengamatan dilakukan terhadap profil protein dengan SDS Page 2 dimensi, FT- IR dan LCMS. Hasil penelitian menunjukkan ada variasi berat protein, spektrum infra merah (bilangan gelombang) Â dan nilai massa molekul ion (m/z) Â antara kelompok kontrol (K) dan kelompok perlakuan (PO1, PO2, Po3, PO4). Dapat disimpulkan bahwa paparan obat antimalaria artemisinin berulang secara Â  in vitro dapat mempengaruhi pola ekspresi protein Plasmodium falciparum galur Papua 2300.Â
Rasio Ostoklas dan Osteoblas pada Tulang Alveolar Model Tikus Diabetes dengan Aplikasi Gaya Ortodonti
Authors: Hikmah Nuzulul , Shita Amandia Dewi Permana , Maulana Hafiedz
Published: December 2022

Pergerakan gigi secara ortodonti diperoleh melalui remodeling tulang alveolar dan jaringan periodontal sebagai respon terhadap adanya gaya ortodonti. Diabetes dapat mempengaruhi remodeling tulang alveolar. Remodeling tulang alveolar meliputi proses resobsi tulang yang diperankan oleh sel osteoklas, serta pembentukan tulang yang diperankan oleh sel osteoblas. Tujuan penelitian ini adalah untuk mengetahui rasio osteoklas dan osteoblas tulang alveolar pada model tikus diabetes oleh karena aplikasi gaya ortodonti. 24 ekor tikus Wistar dibagi menjadi 6 kelompok yang terdiri dari 3 kelompok kontrol dan 3 kelompok perlakuan diabetes dengan aplikasi gaya ortodonti yang berbeda (10, 20, dan 30 gramforce/grf). Hasil penelitian menunjukkan bahwa aplikasi gaya ortodonti pada model tikus diabetes menyebabkan peningkatan rasio osteoklas dan osteoblas tulang alveolar di daerah tekanan dan tarikan pada ligamen periodontal.
Ekspresi Human Leukocyte Antigenâ€“C di Trofoblas dan Natural Killer Cell di Desidua pada Preeklampsia Berat
Authors: Sulistyowati Sri , Soetrisno Soetrisno , K Nizar Hero
Published: December 2022

Preeklampsia Berat (PEB) masih merupakan penyebab utama morbiditas dan mortalitas maternal maupun perinatal. Kejadian preeklampsia berkisar antara 4,4-17,5% dari ibu hamil. Human Leukocyte Antigen-C (HLA-C) dan Natural Killer cell (sel NK) diduga memegang peranan penting terhadap proses terjadinya preeklampsia. Penelitian ini bertujuan untuk mengetahui ekspresi HLA-C dan sel NK pada PEB, dengan menggunakan metode observasional analitik dan potong lintang. Penelitian dilakukan pada bulan Desember 2014-Januari 2015 di bagian Obstetri dan Ginekologi RSUD Dr. Moewardi Surakarta dan Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Sebelas Maret Surakarta. Jumlah sampel 40 yang telah memenuhi kriteria inklusi dan eksklusi dibagi menjadi 2 kelompok, yaitu 20 PEB dan 20 hamil normal. Semua sampel dilakukan pemeriksaan ekspresi HLA-C pada trofoblasnya dan sel NK pada desidua dengan metode imunohistokimia dan dilakukan analisis statistik dengan uji t. Rerata ekspresi HLA-C di trofoblas pada kelompok PEB : 15,39Â±3,45 dan kehamilan normal 8,07Â±3,70, dengan nilai Â p=0,00 (p<0,05). Â Rerata ekspresi sel NK di desidua pada PEB 14,78Â±3,57 dan kehamilan normal 8,48Â±3,35, dengan nilai p=0,00 (p<0,05). Simpulan, ekspresi HLA-C di trofoblas dan sel NK di desidua pada PEB lebih tinggi dibandingkan dengan kehamilan normal.
Laporan Kasus: Multisystem Langerhans Cell Histiocytosis pada Anak Perempuan Usia Dua Tahun
Authors: WL Eky Indyanty , Arthamin Maimun Z , Nugroho Susanto , Budiman Budiman
Published: December 2022

Langerhans Cell Histiocytosis (LCH) merupakan penyakit yang jarang dengan karakteristik proliferasi dan migrasi sel dendritik atau sel histiosit (sel Langerhans). Kelainan ini terutama mengenai tulang (sistem skeletal) namun dapat juga muncul pada kulit, kelenjar tiroid, kelenjar limfe dan risk organs involvement yaitu hepar, paru, limpa, dan sistem hematopoietik. Kelainan ini relatif langka dan jarang sehingga diagnosis LCH sering kali terlambat atau luput. Diagnosis definit pada LCH yaitu ditemukannya CD1a antigen, S100 protein, atau Langerin (CD207) pada pemeriksaan imunohistokimia atau granula Birbeck pada pemeriksaan mikroskop elektron. Pada kasus ini seorang anak perempuan usia 2 tahun dengan keluhan mata kiri menonjol, terdapat benjolan di belakang kepala, belakang telinga kiri dan leher sebelah kanan. Hasil pemeriksaan fisik didapatkan proptosis okuli sinistra, massa regio occipital, belakang telinga kiri dan leher, hepatomegali, spenomegali. Pada pemeriksaan laboratorium didapatkan anemia mikrositik hipokrom anisositosis, leukositosis, trombositosis. Pemeriksaan sumsum tulang mengesankan terdapat infiltrasi Langerhans cell histiocytosis. Pemeriksaan FNAB mengesankan Langerhans histiositosis. Pemeriksaan foto Schuller menunjukkan lesi litik geografik tulang fronto-temporo-parietal-occipital sinistra, occipital dextra, lesi litik destruktif pada ramus mandibula dextra. Hasil CT-scan kepala menunjukkan hasil soft tissue mass multiple. Hasil pemeriksaan imunohistokimia didapatkan hasil positif S100 protein. Pada kasus ini, pasien didiagnosis LCH atas dasar gambaran morfologi sel Langerhans (FNAB) dan hasil positif S100 protein (imunohistokimia). Beberapa organ yang terlibat antara lain mata, tulang craniofacial, kulit, hepar, limpa, dan sumsum tulang.
Efek Preventif Pemberian Ekstrak Kulit Buah Naga Berdaging Super Merah (Hylocereus Costaricensis) terhadap Malondialdehid Tikus Wistar yang Dipapar Asap Rokok
Authors: Nasution Ade Saputra , Wirjatmadi Bambang , Adriani Merryana
Published: December 2022

Kulit buah naga berdaging super merah Â (Hylocereus costaricensis) merupakan limbah yang sangat jarang dimanfaatkan, biasanya kulit buah naga hanya dibuang begitu saja, padahal mengandung antiosianin yang cukup tinggi. Antosianin yang terkandung dalam kulit buah naga berpotensi dijadikan sebagai alternatif pewarna alami dan antioksidan alami. Penelitian ini bertujuan untuk menganalisis efek pemberian kulit buah naga berdaging super merah terhadap pencegahan kenaikan Malondialdehid (MDA) pada tikus wistar yang diberi paparan asap rokok. Dalam penelitian ini menggunakan lima kelompok, yaitu kelompok kontrol negatif, kelompok kontrol positif, kelompok perlakuan diberi ekstrak 1,575gr/ml, kelompok perlakuan diberi ekstrak 3,150gr/ml dan kelompok perlakuan diberi ekstrak 4,725gr/ml. Kadar MDA dianalisis dengan menggunakan metode TBA (Thiobarbaturic Acid). Penelitian ini dilakukan selama 36 hari, 7 hari pertama diberi ekstrak sesuai dosis, selanjutnya 28 hari kemudian dipapar 2 batang rokok dan diberi ekstrak. Data dianalisis menggunakan uji ANOVA One Way dan LSD. Hasil penelitian menunjukkan kadar MDA pada kelompok positif dengan kelompok pemberian ekstrak 1,575 gr/ml tidak terdapat perbedanyaan nyata (0,079 >0,05). Kadar MDA pada kelompok Â kontrol positif dengan kelompok pemberian ekstrak 3,15gr/ml dan kelompok pemberian ekstrak 4,725gr/ml ada perbedaan nyata (0,00 <0,05). Kelompok pemberian ekstrak 3,15gr/ml dan kelompok pemberian ekstrak 4,725gr/ml dapat mencegah kenaikan kadar MDA pada tikus yang dipapar asap rokok.
Nasopharyngeal Non Hodgkin Lymphoma
Authors: Wardhani Shinta Oktya , Kartikasari Nanik Triana
Published: December 2022

Non Hodgkin lymphomas (NHL) are tumors originating from lymphoid tissue, mainly from lymph nodes. These tumors may result from chromosomal translocation, infections, environmental factors, immunodeficiency states, and chronic inflammation. In general, the incidence of NHL is slightly higher in men than in women. The incidence of NHL nasopharynx is rare. A high degree of suspicion is required to avoid unnecessary radiologic and surgical procedures since NHL can be mistakenly diagnosed as carcinoma. We reported a 16 year old male patient with gradual epistaxis, hearing impairment, decreased body weight, and multiple nodules in right forehead, right axilla, right colli posterior, and left waist. The patient also suffered from inferior paraplegic extremities. The Head CT scan result showed carcinoma nasopharynx. After biopsy of nodules was done, it revealed differential diagnoses such as blastoma, Non Hodgkin lymphoma, and small cell carcinoma. Immunohistochemistry result showed Leucocyte Common Antigen (LCA) positive, and MRI thorax showed suspect of schwannoma. Based on the data, chemotherapy with regiment CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin/vincristine, and prednisone) was given. The prognosis of NHL Nasopharynx was better than nasopharyngeal squamous cell carcinoma. The prognostic of NHL depends on the age, performance status, staging, extranodal involvement, serum Lactate Dehydrogenase (LDH) and response of therapy. The prognosis in our patient was poor.Keywords: Mass, Non Hodgkin Lymphoma, nasopharyngeal carcinoma, prognostic
Manajemen Ruptur Septum Ventrikel Pasca Infark Miokard Akut di Rumah Sakit tanpa Fasilitas Bedah
Authors: Wahjono Andi , Anjarwani Setyasih
Published: December 2022

Ruptur septum ventrikel merupakan komplikasi mekanik yang sangat jarang terjadi pada pasien infark miokard akut (IMA) namun memiliki mortalitas yang tinggi. Sejak dimulainya era reperfusi modern, insiden ruptur septum ventrikel semakin menurun sampai dengan 0,2% kasus IMA. Dalam laporan kasus ini kami laporkan 2 pasien ruptur septum ventrikel pasca IMA. Pasien mendapatkan perawatan intensif dan terapi medikamentosa, selama dalam masa perawatan hemodinamik cenderung tidak stabil dan meninggal beberapa hari kemudian tanpa tindakan invasif karena keterbatasan fasilitas. Intra aortic counterpulsation balloon pump (IABP) dapat dipertimbangkan sebelum operasi sebagai bridging therapy. Operasi merupakan standar baku emas terapi dan bersama dengan Coronary Artery Bypass Graft (CABG) tanpa melihat status hemodinamik. Hasil yang optimal dapat dicapai pada 2-6 minggu pasca serangan akut namun demikian penutupan defek dengan transcatheter septal occluder dalam keadaan tertentu dapat dipertimbangkan. Kata Kunci: Infark miokard akut, operasi, ruptur septum ventrikel, transcatheter septal occluder
Leukemia Sel Plasma Primer
Authors: Hanggara Dian Sukma , Budiman Budiman
Published: December 2022

Leukemia sel plasma merupakan penyakit yang langka, hanya sekitar 2-4% dari plasma cell dyscrasia. Manifestasi klinis leukemia sel plasma primer lebih agresif dibandingkan dengan mieloma multipel. Artikel melaporkan kasus pasien laki-laki berumur 59 tahun datang ke Instalasi Gawat Darurat (IGD) dengan keluhan badan lemah dan nyeri pada kedua kaki sejak sebulan yang lalu dan memberat seminggu terakhir. Pasien juga mengeluhkan nyeri punggung, mual, penurunan nafsu makan, dan penurunan berat badan. Pemeriksaan fisik menunjukkan penurunan respon motorik pada ekstrimitas bawah. Pemeriksaan laboratorium menunjukkan anemia normokrom normositik, leukositosis dengan 60% sel plasma, trombositopenia, hipoglobulinemia, azotemia, hiperkalsemia, hiperfosfatemia, hiponatremia, hipogamaglobulinemia pada elektroforesis protein, dan 50% sel plasma pada aspirasi sumsum tulang. Bone survey menunjukkan proses metastasis pada tulang. Diagnosis leukemia sel plasma primer ditegakkan oleh adanya lebih dari 20% sel plasma atau jumlah absolut sel plasma lebih dari 2x109/l pada darah tepi, tidak ada riwayat mieloma multipel, dan gambaran klinis yang agresif. Kata Kunci: Leukemia sel plasma, mieloma multipel, sel plasma
Pengaruh Pemberian Ekstrak Propolis terhadap Ekspresi Bcl2 dan Apoptosis pada Sel Otak Tikus Model Cedera Otak Traumatik
Authors: Husna Ully , Sujuti Hidayat , Dalhar Mochammad
Published: December 2022

Ekstrak propolis mempunyai efek neuroprotektan melalui berbagai macam cara kerja salah satunya sebagai antioksidan karena bahan kandungan utamanya adalah flavonoid. Penelitian ini bertujuan untuk menguji efek ekstrak propolis berbagai dosis dalam meningkatkan ekspresi Bcl-2 dan menurunkan apoptosis sel otak tikus model cedera otak traumatik. Tikus dibagi menjadi 5 kelompok, yaitu: kelompok normal, kelompok yang diberi perlakuan cedera otak traumatis, kelompok yang diberi perlakuan cedera otak traumatis dan ekstrak propolis masing-masing dosis 50mg/kgBB, 100mg/kgBB, dan 200mg/kgBB. Setiap kelompok diambil otaknya untuk diperiksa ekspresi Bcl-2 dan apoptosis sel otak pada hari ke-7. Berdasarkan hasil analisa statistik, didapatkan hubungan signifikan antara ekspresi Bcl-2 dan apoptosis sel otak tikus model cedera otak traumatik dengan berbagai dosis ekstrak propolis (p<0,05). Dosis 200mg/kgbb merupakan dosis yang paling efektif dalam meningkatkan ekspresi Bcl2 otak tikus dan menurunkan apoptosis sel otak tikus. Penelitian ini telah membuktikan bahwa ekstrak propolis dapat meningkatkan ekspresi Bcl-2 dan menurunkan apoptosis sel otak tikus model cedera otak traumatik.Kata Kunci: Apoptosis sel, cedera otak traumatik, ekspresi Bcl-2, ekstrak propolis
Pengaruh Ekstrak Propolis terhadap Apoptosis melalui Ekspresi Brain-Derived Neurotrophic Factor (BDNF) pada Sel Otak Tikus Model Cedera Otak Traumatik
Authors: Pramesti Fathia Annis , Purnomo Hari , Balafif Farhad
Published: December 2022

Cedera otak merupakan penyebab utama morbiditas dan mortalitas pada semua kelompok umur. Selama cedera kepala terjadi reaksi kaskade inflamasi yang nantinya akan menyebabkan apoptosis dan nekrosis. Propolis memiliki aktivitas antiinflamasi yang kuat melalui peningkatan ekspresi Brain-Derived Neurotrophic Factor (BDNF) yang akan berikatan dengan tyrosine kinase-B (trkB) yang akan menghambat apoptosis, sehingga propolis memiliki potensi sebagai alternatif terapi dalam menurunkan apoptosis melalui peningkatan ekspresi BDNF pada cedera otak traumatik. Penelitian ini bertujuan untuk menguji pengaruh pemberian propolis dalam berbagai dosis pada ekspresi BDNF dan apoptosis di sel otak tikus Rattus norvegicus model traumatik. Sampel dibagi menjadi 5 kelompok, yaitu: kelompok model trauma dan diberi perlakuan propolis masing-masing dosis 50mg, 100mg, dan 200mg, kontrol positif dan kontrol negatif. Pada akhir penelitian, tikus dikorbankan dan dibuat preparat otak untuk menilai ekspresi BDNF dan apoptosis. Berdasarkan hasil analisa statistik, didapatkan hubungan yang signifikan antara ekspresi BDNF dan apoptosis sel otak tikus model traumatik dengan berbagai dosis propolis (p=0,001, r=0,955; p=0,000, r=0,904, korelasi Pearson). Penelitian ini membuktikan bahwa propolis berpengaruh dalam peningkatan ekspresi BDNF dan penurunan apoptosis di sel otak tikus model traumatik.Kata Kunci: Apoptosis, BDNF, cedera otak traumatik, propolis
TNF-Î± and Interleukin-6 Levels in Clinical Early Onset Neonatal Sepsis Toward Acute Liver Injury
Authors: Dinarshanty Diani , AS Noorhamdani , Kawuryan Siti Lintang , Wibowo Satrio
Published: December 2022

TNF-Î± and IL-6 level have an important role in acute liver injury during early onset neonatal sepsis. This study aims to investigate the correlation of TNF-Î± and IL-6 levels in neonates with clinical early onset neonatal sepsis toward the occurrence of acute liver injury 44 neonates with clinical early onset neonatal sepsis based on SIRS criteria and Rodwell hematologic scored â‰¥3 were included in this study. Acute liver injury is defined as elevated of AST, ALT, or AST: ALT ratio <1. TNF-Î± and IL-6 levels were measured using ELISA methods. This study showed that TNF-Î± correlated significantly with AST level (p<0,001, r=0,570), ALT level (p<0,001, r=0,554), and AST: ALT ratio (p<0,001, r=0,652). This study also showed that IL-6 correlated significantly with AST level (p<0,001, r=0,523), ALT level (p<0,001, r=0,482), AST: ALT ratio (p<0,001, r=0,603). Regression test using backward methods showed that TNF-Î± influence acute liver injury (indicated by AST, ALT, and AST: ALT ratio) more than IL-6. We concluded that TNF-Î± and IL-6 level in clinical early onset neonatal sepsis correlated with acute liver injury, whereas early onset neonatal sepsis was correlated with acute liver injury.Keywords: Acute liver injury, clinical early neonatal sepsis, IL-6 level, TNF-Î± level
Demographic, Clinical, and Laboratory Characteristics of HIV Patients with Cerebral Toxoplasmosis at Haji Adam Malik General Hospital Medan
Authors: Kadri Alfansuri , Yandra Eko
Published: December 2022

Cerebral toxoplasmosis is one of the frequent opportunistic infections of the central nervous system of Human Immunodeficiency Virus (HIV) patients in the presence of Toxoplasma Gondii infection. In Indonesia, the incidence of HIV patients with cerebral toxoplasmosis is 45%. This study was done to determine the demographic, clinical, and laboratory characteristics of HIV patients with cerebral toxoplasmosis at Haji Adam Malik Hospital, Medan, based on medical record data in 2022. The total sample was 23 patients with time periods from January to March 2022. Demographically, the data showed that most of the HIV patients with cerebral toxoplasmosis were male (91.3%), a mean age of 36.48 ± 5.74 years, married (87%), high school graduates (69.6%), and working (91.3%). The most common clinical characteristics were headache (69.6%) and cognitive impairment (56.5%). Laboratory characteristics found were (56.5%) non-reactive (<0.8 COI) and (43.5%) reactive (≥1 COI) anti toxoplasma IgM, while reactive anti-toxoplasma IgG (≥3 IU/ml) was obtained in all research samples (100%).
The Effect of the Mucinous Component Presence on the Clinical Outcomes of Colorectal Cancer
Authors: Ozemir Ibrahim Ali , Aydemir Muhammed Ali , Gapbarov Aman , Ekinci Ozgur , Alimoglu Orhan
Published: December 2022

Background. The effect of colorectal cancer (CRC) histological subtypes on the prognosis is still a controversial issue. We aimed to compare clinical findings, histopathologic data, and survival outcomes in CRC patients with classical and mucinous subtypes.

Methods. Patients who were operated on for CRC between 2010 and 2017 were included in the study. Patients were classified into two groups according to the presence of a mucinous component: mucinous adenocarcinoma (MAC) - mucinous component > 50% and classical adenocarcinoma (CAC). Clinical and histopathologic findings, recurrence, metastasis, and survival rates were compared.

Results. Data of the 484 CRC patients were documented. Sixty-nine patients (14.3%) were in the MAC group and 415 (85.7%) patients were in the CAC group. The mean age of patients with MAC and CAC was 63.4 ± 13.5 and 68.5 ± 12.7 years, respectively (p = 0.002). Proximal colon localization was found in 30 (43.5%) MAC patients and 123 (29.6%) CAC patients (p = 0.029). The number of patients with metastatic lymph nodes was higher in the MAC group (58% vs. 41.2%, p = 0.03). Nevertheless, there was no significant difference between the CAC and MAC groups in terms of disease-free survival (63.1% vs. 69.6%, p = 0.37) and disease-related mortality (23.6% vs. 23.2%, p = 0.94) over the follow-up period. Multivariate analysis showed that the presence of perineural invasion, patient’s age, and disease stage were associated with mortality in CRC patients.

Conclusions. MACs occurred at a younger age than CACs and were more likely localized in the proximal colon as compared to CACs. Despite increased lymph node metastasis in MAC patients, no statistical significance was detected in overall survival or disease-free survival. Multivariate analysis revealed that age, perineural invasion, and disease stage were relevant to mortality in CRC patients.
PENGARUH STRES AKADEMIK, FASILITAS BELAJAR, DAN LINGKUNGAN BELAJAR TERHADAP MOTIVASI BELAJAR DARING MAHASISWA
Authors: Merina Ramadan Merina Ramadan , Yushita Amanita Novi
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh: (1) Stres Akademik terhadap Motivasi Belajar Daring, (2) Fasilitas Belajar terhadap Motivasi Belajar Daring, (3) Lingkungan Belajar terhadap Motivasi Belajar Daring Mahasiswa. Penelitian ini merupakan penelitian jenis kuantitatif asosiatif hubungan kausal. Responden penelitian ini berjumlah 141 Mahasiswa Program Studi Pendidikan Akuntansi Fakultas Ekonomi Universitas Negeri Yogyakarta angkatan 2018, 2019 dan 2020. Teknik pengambilan sampel menggunakan probability sampling. Teknik pengumpulan data menggunakan kuesioner yang disebarkan secara online dan kemudian dianalisis menggunakan regresi linear berganda. Hasil penelitian menunjukkan bahwa: (1) Stres Akademik berpengaruh positif dan signifikan terhadap Motivasi Belajar Daring. Hal ini dapat dilihat dari nilai t hitung t tabel (10,095 1,977) dengan signifikansi 0,000 lebih kecil dari 0,05. (2) Fasilitas Belajar tidak berpengaruh positif dan signifikan terhadap Motivasi Belajar Daring. Hal ini dapat dilihat dari nilai t hitung t tabel (1,898 1,977) dengan signifikansi 0,600 lebih besar dari 0,05. (3) Lingkungan Belajar berpengaruh positif dan signifikan terhadap Motivasi Belajar Daring. Hal ini dilihat dari nilai t hitung t tabel (2,127 1,977) dengan signifikansi 0,028 lebih kecil dari 0,05. Kata kunci: motivasi belajar daring, stres akademik, fasilitas dan lingkungan belajar.
Interpretable Machine Learning Prediction of Drug-Induced QT Prolongation: Electronic Health Record Analysis
Authors: Simon Steven T , Trinkley Katy E , Malone Daniel C , Rosenberg Michael Aaron
Published: December 2022

Background

Drug-induced long-QT syndrome (diLQTS) is a major concern among patients who are hospitalized, for whom prediction models capable of identifying individualized risk could be useful to guide monitoring. We have previously demonstrated the feasibility of machine learning to predict the risk of diLQTS, in which deep learning models provided superior accuracy for risk prediction, although these models were limited by a lack of interpretability.

Objective

In this investigation, we sought to examine the potential trade-off between interpretability and predictive accuracy with the use of more complex models to identify patients at risk for diLQTS. We planned to compare a deep learning algorithm to predict diLQTS with a more interpretable algorithm based on cluster analysis that would allow medication- and subpopulation-specific evaluation of risk.

Methods

We examined the risk of diLQTS among 35,639 inpatients treated between 2003 and 2018 with at least 1 of 39 medications associated with risk of diLQTS and who had an electrocardiogram in the system performed within 24 hours of medication administration. Predictors included over 22,000 diagnoses and medications at the time of medication administration, with cases of diLQTS defined as a corrected QT interval over 500 milliseconds after treatment with a culprit medication. The interpretable model was developed using cluster analysis (K=4 clusters), and risk was assessed for specific medications and classes of medications. The deep learning model was created using all predictors within a 6-layer neural network, based on previously identified hyperparameters.

Results

Among the medications, we found that class III antiarrhythmic medications were associated with increased risk across all clusters, and that in patients who are noncritically ill without cardiovascular disease, propofol was associated with increased risk, whereas ondansetron was associated with decreased risk. Compared with deep learning, the interpretable approach was less accurate (area under the receiver operating characteristic curve: 0.65 vs 0.78), with comparable calibration.

Conclusions

In summary, we found that an interpretable modeling approach was less accurate, but more clinically applicable, than deep learning for the prediction of diLQTS. Future investigations should consider this trade-off in the development of methods for clinical prediction.
How COVID-19 Affected the Journal Impact Factor of High Impact Medical Journals: Bibliometric Analysis
Authors: Delardas Orestis , Giannos Panagiotis
Published: December 2022

Background

Journal impact factor (IF) is the leading method of scholarly assessment in today’s research world, influencing where scholars submit their research and where funders distribute their resources. COVID-19, one of the most serious health crises, resulted in an unprecedented surge of publications across all areas of knowledge. An important question is whether COVID-19 affected the gold standard of scholarly assessment.

Objective

In this paper, we aimed to comprehensively compare the productivity trends of COVID-19 and non–COVID-19 literature as well as track their evolution and scholarly impact across 3 consecutive calendar years.

Methods

We took as an example 6 high-impact medical journals (Annals of Internal Medicine [Annals], The British Medical Journal [The BMJ], Journal of the American Medical Association [JAMA], The Lancet, Nature Medicine [NatMed], and The New England Journal of Medicine [NEJM]) and searched the literature using the Web of Science database for manuscripts published between January 1, 2019, and December 31, 2021. To assess the effect of COVID-19 and non–COVID-19 literature in their scholarly impact, we calculated their annual IFs and percentage changes. Thereafter, we estimated the citation probability of COVID-19 and non–COVID-19 publications along with their rates of publication and citation by journal.

Results

A significant increase in IF change for manuscripts including COVID-19 published from 2019 to 2020 (P=.002; Annals: 283%; The BMJ: 199%; JAMA: 208%; The Lancet: 392%; NatMed: 111%; and NEJM: 196%) and to 2021 (P=.007; Annals: 41%; The BMJ: 90%; JAMA: 6%; The Lancet: 22%; NatMed: 53%; and NEJM: 72%) was seen, against non–COVID-19 ones. The likelihood of highly cited publications was significantly increased in COVID-19 manuscripts between 2019 and 2021 (Annals: z=3.4, P<.001; The BMJ: z=4.0, P<.001; JAMA: z=3.8, P<.001; The Lancet: z=3.5, P<.001; NatMed: z=5.2, P<.001; and NEJM: z=4.7, P<.001). The publication and citation rates of COVID-19 publications followed a positive trajectory, as opposed to non–COVID-19. The citation rate for COVID-19 publications peaked by the second quarter of 2020 while that of the publication rate approximately a year later.

Conclusions

The rapid surge of COVID-19 publications emphasized the capacity of scientific communities to respond against a global health emergency, yet inflated IFs create ambiguity as benchmark tools for assessing scholarly impact. The immediate implication is a loss in value of and trust in journal IFs as metrics of research and scientific rigor perceived by academia and society. Loss of confidence toward procedures employed by highly reputable publishers may incentivize authors to exploit the publication process by monopolizing their research on COVID-19 and encourage them to publish in journals of predatory behavior.
The Influence of Failover on Software-Defined Network and Conventional Network
Authors: Subardono Alif , Saputra Riffat Hasan
Published: December 2022

The growing use of the Internet resulted in the number of agencies that use two or more internet gateway paths or so-called Internet Service Providers (ISPs) to maintain network availability. Using two or more gateway paths allows break-up of connections on one of the gateway paths. This study aims to determine the effect of failover on SDN and conventional networks that are integrated with load balancing method of ECMP on MikroTik RB951-2n router device. The controller used on the SDN network is OpenDaylight. Testing is done by doing failover test which then data of bandwidth traffic from both network architecture recorded using Graphing tool from MikroTik. For average traffic efficiency without failover influence on conventional network better with difference of 9.8%. And with the difference in efficiency of 0.5% menunujukkan that the effect of failover on the SDN network is still better than the conventional network.
Implementasi dan Analisis Performa Protokol Message Queuing Telemetry Protocol Jaringan Smart Farming Pada Budidaya Jamur Tiram Dengan Memanfaatkan Internet Of Things
Authors: Sidiq Rilo Pambudi  , Alif Subardono
Published: December 2022

Abstract – The development of technology, gives many effects for human life. Many things can be controlled automatically and remotely. Internet of Things is as one of technology development which can be a solution to make human life easier. Internet of Things can also be used in agriculture sector and smart farming.

Oyster growth is very affected by temperature and humidity. The temperature needed for growing of oyster is 24-28 Celsius degree. The use of Internet of Things is needed to monitor, take care and increase the productivity. Implementation of Smart Farming in agriculture sector, such as the using of protocol Message Queuing Telemetry Transport (MQTT) as a media of data traffic among censor, server and receiver of data. Message Queuing Telemetry Transport (MQTT) as protocol which can work as real time and work in low bandwidth, so the traffic of data works smoothly although in low bandwidth

Keywords:  Internet Of Things , Smart Farming, MQTT, QoS

 

Intisari – Perkembangan teknologi memberikan banyak dampak pada kehidupan manusia. Banyak hal dapat dikontrol otomatis dari jarak jauh. Internet of Things (IoT) sebagai teknologi yang dapat menjadi solusi untuk mempermudah pekerjaan manusia. Internet of Things (IoT) dapat digunakan pula di bidang pertanian atau perkebunan pintar (Smart Farming).

Tanaman Jamur Tiram sangat dipengaruhi oleh temperatur dan kelembaban. Kondisi udara saat pertumbuhan Jamur Tiram berada pada suhu 24-28 derajat Celcius. Penggunaan Internet of Thing (IoT) di bidang pertanian dapat mendukung pemantauan, perawatan dan meningkatkan produktifitas. Penerapan Smart Farming di bidang pertanian salah satunya dengan menggunakan protocol Message Queuing Telemetry Transport (MQTT) sebagai sarana lalu lintas data antara sensor, server dan penerima data. Message Queuing Telemetry Transport (MQTT) merupakan protocol yang dapat bekerja secara realtime dan dapat bekerja pada bandwidth yang rendah, sehingga lalu lintas data tetap lancar walaupun menggunakan bandwidth yang rendah.

Kata Kunci : Internet Of Things , Smart Farming, MQTT, QoS
Implementasi dan Analisis QoS pada Smart Door yang Terintegrasi dengan Aplikasi Telegram
Authors: Aidah Khuriatul Mujtahidah  , Oktiawati Unan Yusmaniar
Published: December 2022

Home security is a mandatory requirement for every homeowner. With home security, homeowners will always feel safe leaving the house for a long time. In this final project, the author made a smart door with its main components are the HC-SR04 ultrasonic sensor and web camera. The function of the ultrasonic sensor and webcam is to detect a movement in the area around the access of people. In this system, not only can it detect movement, but also send notifications in the form of text and videos through the Telegram application so that homeowners can find out if someone tries to enter the house even though the owner of the house is away from his house. The author also adds dual security in the form of a remote control system, where when the homeowner knows of theft, the homeowner simply sends a "close" message through the Telegram application, so the door automatically locks and keeps the thief for a while until the homeowner arrives at location. This remote control system can also be used when the homeowner forgets to lock the door so that when the owner of the house is away from home, he simply controls the door through the telegram application.
Analysis and Implementation of Raspberry Pi Based Wireless Access Point and User Access Notification Using Telegram
Authors: Pratama Nashruddin Putra , Oktiawati Unan Yusmaniar
Published: December 2022

Internet network technology has become a human need in almost every activity. Communities in areas experiencing a lack of fiber optic network infrastructure need a tool to access the internet that can be used together in an affordable and efficient manner. This study tries to provide a solution to these problems. Raspberry Pi-based Wireless Access Point uses a USB modem which functions to build a Wireless Local Area Network. Then, a network quality test is carried out by calculating QoS on network traffic including packet loss, throughput and latency with scenarios based on a distance of 0 meter, 4 meter and 8 meter between the Wireless Access Point and the client by conducting online meetings and video streaming. Furthermore, to make it easier to monitor the Raspberry Pi device that acts as a Wireless Access Point, it will send user information that is connected via the Telegram bot.
The Influence of Support Materials on The Photo-Fenton-like Degradation of Azo Dye Using Continuous Nanoparticles Fixed-bed Column
Authors: Mahmoud Zainab A. , Atyia Mohammed A. , Hassan Ahmed K.
Published: December 2022

This study used a continuous photo-Fenton-like method to remediate textile effluent containing azo dyes especially direct blue 15 dye (DB15). A Eucalyptus leaf extract was used to create iron/copper nanoparticles supported on bentonite for use as catalysts (E@B-Fe/Cu-NPs). Two fixed-bed configurations were studied and compared. The first one involved mixing granular bentonite with E@B-Fe/Cu-NPs (GB- E@B-Fe/Cu-NPs), and the other examined the mixing of E@B-Fe/Cu-NPs with glass beads (glass beads-E@B-Fe/Cu-NPs) and filled to the fixed-bed column. Scanning electron microscopy (SEM), zeta potential, and atomic forces spectroscopy (AFM) techniques were used to characterize the obtained particles (NPs). The effect of flow rate and DB15 concentration on the photo-Fenton-like degradation of DB15 in continuous fixed-bed systems was investigated. To optimize both studied systems, the response surface methodology using the central composite design (CCD) was used. The analysis shows that the removal efficiency for GB-E@B-Fe/Cu-NPs was 81% and for glass beads-E@B-Fe/NPs was 62.6%.
Comparative Transfer Learning Models for End-to-End Self-Driving Car
Authors: Khidhir Yahya Ghufran , Morad Ameer Hussein
Published: December 2022

Self-driving automobiles are prominent in science and technology, which affect social and economic development. Deep learning (DL) is the most common area of study in artificial intelligence (AI). In recent years, deep learning-based solutions have been presented in the field of self-driving cars and have achieved outstanding results. Different studies investigated a variety of significant technologies for autonomous vehicles, including car navigation systems, path planning, environmental perception, as well as car control. End-to-end learning control directly converts sensory data into control commands in autonomous driving. This research aims to identify the most accurate pre-trained Deep Neural Network (DNN) for predicting the steering angle of a self-driving vehicle that is suitable to be applied to embedded automotive technologies with limited performance. Three well-known pre-trained models were compared in this study: AlexNet, ResNet18, and DenseNet121.
Transfer learning was utilized by modifying the final layer of pre-trained models in order to predict the steering angle of the vehicle. Experiments were conducted on the dataset collected from two different tracks. According to the study's findings, ResNet18 and DenseNet121 have the lowest error percentage for steering angle values. Furthermore, the performance of the modified models was evaluated on predetermined tracks. ResNet18 outperformed DenseNet121 in terms of accuracy, with less deviation from the center of the track, while DenseNet121 demonstrated greater adaptability across multiple tracks, resulting in better performance consistency.
BCI-Based Smart Room Control using EEG Signals
Authors: Amanuel Oger Zaya , Alazzawi Yarub
Published: December 2022

In this paper, we implement and examine a Simulink model with electroencephalography (EEG) to control many actuators based on brain waves. This will be in great demand since it will be useful for certain individuals who are unable to access some control units that need direct contact with humans. In the beginning, ten volunteers of a wide range of (20-66) participated in this study, and the statistical measurements were first calculated for all eight channels. Then the number of channels was reduced by half according to the activation of brain regions within the utilized protocol and the processing time also decreased. Consequently, four of the participants (three males and one female) were chosen to examine the Simulink model during different actions. The model contained: input signals, data selection according to the activation regions in the brain, features extraction, classification according to the frequency ranges of each action, and an interface with an embedded system to control the actuators.
Demystification of the Organic Theory of Company Law through the Lens of Corporate Governance Jurisprudence: Revisiting Shareholders Activism (A Case Study of Nigeria’s Company and Allied Matters Act 2004)
Authors: AJOKU ESQ O. OGECHUKWU
Published: December 2022

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Analysis on the Factors Affecting the Performance of Platform Based Matchmaking Enterprises
Authors: Li Guizi
Published: December 2022

The matchmaking service platform is an organization that integrates and matches resources for bilateral users. In the dynamic process of resource integration and exchange of services, its subject elements, object elements, technology elements and environmental elements will affect the performance of enterprises to varying degrees. Among them, the object element is mainly reflected in the resource management ability and information matching ability. This paper collected the evaluation of single users on the selection and use of the matchmaking platform through platform questionnaires, and made an in-depth analysis of the main factors affecting the performance of platform based matchmaking enterprises.
Manifestation of Colonial Subjects in Twilight in Dehli and A Passage to India
Authors: Anwar Ansa , Irshad Aasma , Batool Maria , Zubair Hassan Bin
Published: December 2022

The goal of this research is to examine how the colony is portrayed by both the colonizer and the colonized. This paper focuses mainly on the politics of depiction by implementing the insights of postcolonialism. In this context, Twilight in Delhi by Ahmed Ali also deals with the same subject from the view of the colonized, whereas A Passage to India is a narrative of the British colony by its colonizer E. M. Forster. It may be argued that the writers’ two depictions of a similar colony represent different political and cultural viewpoints. The two authors’ representations of the same colony, one from a colonized civilization and another from that was colonized, consistently reflect their distinctive voices. Additionally, the latest research has incorporated Homi K. Bhabha and Edward Said’s analytical works on the depiction in the postcolonial theoretical perspective and explored the problem of cultural representation while using textual analyses. The research has shown that both works’ representations of colonial India differ significantly because of the authors’ respective cultural roles as colonizer and colonized.
The effects of Pilates on pain, functionality, quality of life, flexibility and endurance in lumbar disc herniation
Authors: Taşpınar Gülşan , Angın Ender , Oksüz Sevim
Published: December 2022

Aim:
To assess the effects of clinical Pilates exercises (CPE) on the level of pain, functional status, flexibility, static and dynamic endurance of the trunk muscles and quality of life (QoL) in patients with lumbar disc herniation.
Materials & methods:
Individuals were divided into two groups: the CPE (6 weeks, three-times a week) group (n = 27) and the control group (n = 27). The clinical outcome measures were the visual analog scale for the evaluation of the pain intensity, Oswestry disability index for functional disability, short form-36 for health related QoL, sit and reach and hand finger floor distance test for the flexibility, side-bridge and sit-ups test for the static and dynamic endurance.
Results:
At the end of the 6 weeks the amount of decrease in the level of pain and Oswestry disability index, amount of increase in sit-reach test and hand-finger-to-floor distance, duration of the lateral bridge and sits-ups test and most of the short form-36 sub parameters was significantly higher (p < 0.05) in the CPE group.
Conclusion:
 CPE was an effective and safe method for symptomatic patients with lumbar disc herniation in reducing the pain level and functional disability and improving flexibility, static and dynamic endurance and partially their QoL.

Clinical Trial Registration
:
NCT03198273
(
ClinicalTrials.gov
).
Analysis of Steel Plate Shear Wall System Using Finite Element Analysis: A Review
Authors: Agrawal Payal , Patel Mahesh Ram
Published: December 2022

Abstract: The shear walls are lateral load resisting system used in high rise buildings located in earthquake prone zone. The current research reviews various researches conducted in improving shear behaviour of high rise building using shear walls. These researches are conducted using both experimental and numerical techniques. The analytical equation evaluating deformation and shear stress on shear wall is also presented.
Carrying Traditions of Vibrant IKAT Ahead –Innovative Approaches through Academia
Authors: Sharma Rajesh , Arora Richa , Kerketta Pradeep John
Published: December 2022

Abstract: Ikat has been carrying a long history through its vibrant blurred texture, colours, yarns and abstraction in design. Ikat of Odisha has carved its own worldwide identity in traditional textiles and cultures of India. Ikat is on revival again in fashion trends with the support of Indian fashion industry professionals, creating new style statement by Indian designers at national and international platforms. New generation has understood the uniqueness of Ikat fabrics and its design development techniques. Different Ikat style patterns have been developed by designer for latest fashion trends in apparel, home furnishing and other products. New innovative approach in Ikat design pattern with the use of new color schemes, yarns and alternate training & development methods has infused new life for the sustainability of this fabric in future and improving the economy of traditional craftsmen and weavers. Academia can fully participate and cooperate to carry ahead this traditional textile –Ikat for future generations and its sustainability. Younger generation can be given awareness about Ikat techniques and potential of Ikat fabric in fashion trends by imparting training in methods & material in accordance with new age approach and trends. Development and training students on Ikat with handloom & digital tool to come up with new innovations.
Multi-Lingual Sign language Detection System
Authors: Wagh Jagruti , Jadhav Gandhali , Joshi Neha , Kamble Atharva , Patil Yukta
Published: December 2022

Abstract: Sign language is the best possible communication facility for the hearing-impaired population as a result, its importance increases and research needs to be done for the systems successful implementation. This medium is a vital part of the communication process between individuals with hearing loss. In this paper, we present a framework for developing a word recognition system using a deep learning method where each method has its strength and limitations. Here, we review the various methods available in sign language recognition such as convolutional neural network (CNN) along with long short-term memory (LSTM), recurrent neural network (RNN), and hidden Markov model (HMM) understanding model behaviour and working. Creating a model which will read static as well as dynamic hand gestures and give output in written format.
Discriminative Transfer Learning for Driving Pattern Recognition in Unlabeled Scenes
Authors: Tukaram Ghodake Sanket , Anil Jadhav Tushar , Vishwanath Pund Mayuri , Vishwanath Pund Raviraj , Kantilal Dandekar Pooja
Published: December 2022

Abstract: Driving behavior has a large impact on behaviour of driver. The lack of a labeled data problem in a driving scene substantially hinders the driving pattern recognition accuracy. However, modeling driving behavior under the dynamic driving conditions is complex, making a quantitative analysis of the the driving behaviour. In this paper, the Driver behaivor dataset was collected from dataset repository. Then, we have to implement the pre-processing techniques. Then, the system is developed the machine learning algorithm such as Random forest and Support Vector Machine algorithm. The experimental results shows that some performance metrics such as accuracy, precision, recall and f1-score. By using the ML is, to classify the Aggressive, normal, slow.