bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY ON THE INITIATION TIME OF IMBIBITION TENSILE CRACKS AND INFLUENCING FACTORS BASED ON NUCLEAR MAGNETIC RESONANCE
Authors: Lu Hongfeng , Yong Chengzhen , Yang Liu , Xu Chenlu , Sa Rina , Feng Xiaoyu
Published: October 2022

The imbibition of hydrate dissociation water into the sediment can lead to fracture expansion and complete dispersion of the skeleton structure, which impacts the depressurization drainage of the hydrate. However, there are no studies on the initiation time of imbibition tensile cracks. In this paper, the drip imbibition method and nuclear magnetic resonance (NMR) technology are used to study the fracture initiation time of hydrate sediments and analyze the related influencing factors. The experimental results show that after water imbibition into the sediment, it will go through four stages of wetting, microfracture, fracture network, and skeleton dispersion, resulting in a two-segment curve of the fracture, and these four stages are divided according to the state of the sample, such as the number of cracks in the sample and whether the skeleton is dispersed. The rate of development of cracks will increase rapidly after reaching the critical time, which can be considered by observing the cracks on the samples. The critical time is when the state of the sample is about to change significantly, which is affected by internal and external factors. For instance, as the whole rock's initial water and mineral content increases, the critical time shortens. However, as porosity and permeability increase, or stress is added to the boundary, the critical time increases. Different fluids have different effects on the critical time; for example, oil makes the critical time be prolonged, whereas potassium chloride solution shortens the critical time. Hence, study of factors affecting the critical time is of great significance for production optimization from hydrate sediments.
The Instances of Delineation in Rock-Culture Discourse
Authors:   Perm State Institute of Culture, Russian Federation, Dyukin Sergey
Published: October 2022

The main concepts of the article are discourse and instances of delineation. This is a set of social institutions that can form the structure of discourse, identify its main and secondary segments. The aim of the research is identification of the instances of delineation in the discourse of rock-culture. The methods of this research included narrative interviews with agents of rock-culture and discourse-analysis. Agents of rock-culture are musicians, their close friends, collector of discs, fans. The research allows us to draw the following conclusions. In the discourse of rock-culture the role of such institutions is fulfilled by a friend, a senior member of family, media and music shops. The friend that structures the discourse should have authority and prestige. They define aesthetic positions, give assessments and exert informational impact. A friend can influence both temporarily and permanently. A senior member of the family affects the discourse in the same way. Other instances of delineation are media and music shops. Media has the effect in rock-discourse of setting the agenda. Methods of forming the agenda are nomination of facts and rankings. A music shop organizes conversation between different agents of rock-culture. A shop operates like media. It provides positive nomination segments of discourse: the demanded goods create a certain verbal series influencing a visitor of the shop. A visitor enters a certain context that leads them to perceive themselves as a referent product that can further the thesaurus of the subject. The structure of the discourse formation is determined by the institutions that act both in the public and in the private field of cultural being. The public instances of delineation are media and musical shops (or market in the reality of Soviet culture). So the discourse of rock performs a double function. It introduces the subject into the sphere of social and cultural innovations. At the same time rock that has a private character returns one to cultural traditions.
Socio-Cultural Potential of Rural Lifestyle from the Perspective of New Civilizational Relations: A View from Siberia
Authors:   Altai State Agricultural University, Barnaul, Russian Federation, Artamonova Tatyana
Published: October 2022

The research interest in the rural lifestyle is due to several trends. On the one hand, it is the deepening depopulation of rural areas and the growth of crisis phenomena. On the other hand, there is a trend of deurbanization, which it is legitimate to consider not only as a temporary consequence of the pandemic situation, but as an aspect of the formation of fundamentally new civilizational relations, the need for which is stated both internationally and at the Russian level. Thus, the reports of the Club of Rome argue for the inevitability of the transition to a new paradigm of development. In the Russian scientific and philosophical literature, one of the alternative civilizational models has been called noospheric or spiritual-ecological, which should replace the prevailing technogenic-consumer model today. At the same time, the values and attitudes that dominate today are criticized first of all, and a return to a number of basic traditional values, preserved, in particular, in the rural way of life, is asserted at a new level. The purpose of the study is divided into three main ones: to isolate the basic values and socio-cultural traditions of the Russian and, above all, the Siberian peasantry, which correspond to the spiritual and ecological civilizational relations; to identify the degree of prevalence of these values in the modern youth environment of Siberia; to give a general assessment of what is happening and offer their recommendations. As a result of the conducted survey of students of agricultural universities in Siberia, it was noted that the key socio-cultural attitudes and values of the rural lifestyle, namely: nature centrism, hard work, the dominance of direct human communication and mutual assistance, nepotism and the continuity of generations have largely been preserved. The rural way of life still retains its deep potential for the reproduction of the cultural, social and family way of life. But at the same time, it is actively undergoing destruction and transformation, which requires the adoption of appropriate socio-economic measures and infrastructural transformations, taking into account global trends in the development of a “smart village”. A significant role in realizing this potential is assigned to young people, namely graduates of agricultural universities as future professionals in the field of agriculture. The methodology of the research was based theoretically, firstly, on a detailed and multidimensional critique of modern civilization, presented in the works of many authors (the Frankfurt School, E. Fromm, the works of the Club of Rome, etc.); secondly, on studies of the state of modern rural areas, in particular in Siberia. Sociological methods such as questionnaires and express surveys were used as empirical methods.
High-level simulation model of tourism industry dynamics
Authors: Gintciak Aleksei , Bolsunovskaya Marina , Burlutskaya Zhanna , Petryaeva Alexandra
Published: October 2022

This article is devoted to the development of a high-level simulation model of tourism industry dynamics. The purpose of this study is to form recommendations for the recovery of the tourism industry from the effects of the pandemic. The resulting model considers domestic tourism from the point of view of the interdependence of the economic condition of the state, the contribution of the tourism industry to gross domestic product, the size of the tourist flow and the average income per tourist. In addition to describing the functional dependencies of the model elements, several experiments are proposed to test the logic of the elements’ relationships. System dynamics tools are used to develop the model. The study also examines the class of computable general equilibrium models as a tool for analyzing supply and demand in the market of tourist products.
Semantic Prosody of Research Verbs: A Corpus-Informed Study
Authors: Al-Otaibi Ghuzayyil Mohammed
Published: October 2022

Background. Synonymous words behave differently, and language users should be aware of the fact that though near-synonyms share similar denotational meanings, they require different collocates. Further, with specific collocates, they provoke a special affective meaning called semantic prosody. To give an example of this problematic area, researchers use a lot of reporting verbs that merely describe an opinion such as argue, claim, believe, etc. or state facts such as find, confirm, cite, etc. Such verbs cannot be used interchangeably as some novice researchers usually do when they discuss their findings or compare their results with others'.

Purpose. This study aimed at examining the semantic prosody of 24 research verbs commonly used by researchers. For this purpose, collocational behavior of nearly synonymous verbs was examined. Compared to previous studies, this study considered only adverbs co-occurring with such research verbs.   

Methods. The researcher used the Directory Open Access Journals (DOAJ), which is of 2.6 billion words and 659,132 texts, and focused on predicational adverbs that end in –ly. For the purpose of the study, adverbs with positive semantic prosody are those proving a stronger attitude towards the proposition, improving the quality, quantity, manner of a piece of information or its the relation to the topic or those suggesting a higher level of certainty.

Results. Investigating 24 research verbs related to hypothesizing, reporting, and summarizing, the researcher found that such verbs have different sets of collocates and thus distinct semantic prosodies. Results showed that 12 of the research verbs were positive (i.e., quantify, argue, claim, suggest, state, mention, indicate, outline, summarize, encapsulate, recapitulate, and reveal), whereas 12 verbs (i.e., hypothesize, review, conclude, presume, posit, assume, theorize, speculate, note, report, find, and postulate) were neutral.

Implications. The study has its own implications for writing instructors and researchers. Novice researchers should not use some research verbs interchangeably as they require different collocates of adverbs. Further, future research should address the relationship between word's etymology and semantic prosody as the present study showed that verbs derived from Latin (e.g., conclude, hypothesize, postulate, etc.) are neutral compared to those that are originally French.
Does Journal Indexation Matter? A Genre-Approach Move Analysis of Nursing English Research Article Abstracts
Authors: Lubis Arif Husein , Kurniawan Eri , Gunawan Wawan
Published: October 2022

Background. A plethora of previous studies have discussed the importance of a genre-approach move analysis because the analysis results can provide a picture of the typical conventions of research article writing across disciplines.
Purpose. Nursing as a professional discipline, however, has received scant attention, particularly in the abstract section in the journals with different indexation. To fill such an empirical void, this qualitative study probes the notion of whether journal indexation matters in manifesting the rhetorical moves in the nursing abstracts.
Methods. Fifty abstracts from a Scopus-indexed Q1 journal and another 50 from three Sinta-indexed journals in Indonesia were analyzed manually. This study employed a descriptive comparative approach to analyze and present the data.
Findings. The findings demonstrated conformity manifestations of method and results moves along with their linguistic realizations by using simple past tense in active or passive forms. The article abstracts from the Scopus-indexed nursing journal emphasized the novelty of the research more than their counterparts from the identification of gap of previous research and highlighting the significance of the study.
Implications. This study suggests writers consider the contributing role of journal indexation type in projecting a higher standard of abstract writing in preparing their abstracts to increase the acceptance rate during an initial screening stage.
Ampisilinin Sn/Sb/Ni-Ti Anotlarla Elektrokimyasal Olarak Giderimine Çeşitli Parametrelerin Etkisi
Authors: KURT Ayşe , SHAKİR Fanar , YONAR Taner
Published: October 2022

Bu çalışmada, ampisilin antibiyotiği içeren atıksuların elektrokimyasal oksidasyonunda yeni nesil Sn/Sb/Ni-Ti anotların uygulanabilirliğinin araştırılması amaçlanmıştır. Elektrolit olarak değerlendirmek üzere sodyum klorür ve potasyum klorür olmak üzere iki farklı tür tuz kullanılmıştır. Ancak, potasyum klorür ile giderim verimleri daha yüksek bulunmuştur. Potasyum klorür ile ampisilin ve kimyasal oksijen ihtiyacının tamamen giderilmesi sırasıyla 5 ve 60 dakika reaksiyon süresi sonunda gerçekleşirken; sodyum klorür ile sırasıyla 5 ve 90 dakika sonra gerçekleşmiştir. Sonuç olarak optimum elektrokimyasal reaksiyon koşulları 750 mg L-1 potasyum klorür ilavesi, pH 8 ve 50 mA cm-2 akım yoğunluğu olarak bulunmuştur. Bu çalışmanın sonucunda, ampisilinin bozunması için yeni nesil Sn/Sb/Ni-Ti anotları ile elektrokimyasal oksidasyon prosesleri, daha az reaksiyon süresi ihtiyacı, tam mineralizasyonun sağlanması ve pH ayarlama adımına ihtiyaç duyulmaması açısından gelecekteki uygulamalar için bu konuda umut verici görünmektedir.
Doğrusal Fresnel kolektörün performans analizi
Authors: YILDIRIM Erdal
Published: October 2022

Güneş enerjisini daha verimli kullanmak için büyük bir potansiyele sahip olan doğrusal Fresnel kolektörlerin tasarım sürecinde performanslarını en doğru şekilde analiz edebilmek için doğrulanmış bir simülasyon modeline ihtiyaç vardır. Bu amaçla Doğrusal Fresnel kolektörün ısı transfer kapasitesini daha iyi anlamak için Harran Üniversitesi GAPYENEV bünyesinde kurulu sisteme ait geometrik model ve optik değerler hem ANSYS Fluent hem de Tonatiuh kullanılarak simüle edilmiştir. Simülasyonlar sonucunda sistemin optik verimini ve alıcı içerisindeki soğurucu boru üzerine düşen ışınım dağılımı bulunarak karşılaştırılmıştır. Alıcıdan gerçekleşen ısı kayıpları bulunarak faydalı enerji miktarı hesaplanmıştır. Seçilen ısı transfer akışkanı için sabit debi ve giriş sıcaklığında simülasyonu yapılarak sistemin ısıl verimi bulunmuştur. Doğrusal Fresnel kolektörün deneysel verilerle elde edilen ısıl verimi 0.348 bulunurken ANSYS Fluent modeli ile hesaplanan ısıl verimi 0.3223 olarak bulunmuştur.
Üç boyutlu modellenen organlar üzerinde dokunsal cihaz kullanılarak deformasyonun simülasyonu
Authors: BULUT Nazmiye Ebru , DANDIL Emre
Published: October 2022

Günümüzde, bilgisayar grafiklerindeki gelişmeler sayesinde, birçok nesnenin asıllarına uygun şekilde sanal ortamda 3B modellenebilmesinde kayda değer gelişmeler elde edilmektedir. Tıp eğitiminde geliştirilen simülatörler ile organlar üzerinde doktor adaylarının çeşitli senaryolar kullanarak sayısız tekrar yapmalarına olanak sağlanarak pratik kazanmaları gerçekleştirilmektedir. Bu çalışmada, insan vücudu içerisinde bulunan safra, böbrek ve dalak gibi yumuşak dokuya sahip organların deformasyon algoritmaları ile yüzeysel benzetimlerinin yapılabilmesi için bir simülatör yazılım platformu geliştirilmiştir. Geliştirilen simülatör üzerinde, tasarlanan dokunsal cihaz donanımı ile anatomik yapılarına uygun şekilde 3B olarak modellenen organlar üzerine dokunulduğunda ya da çekme kuvveti uyguladığında model üzerinde gerçekleşen deformasyonun gerçekleşmesi sayesinde geri bildirim sağlanmıştır. Çalışmada, deformasyonun alınabilmesi için kütle yay ve moleküler modelleme metotları kullanılmıştır. Ek olarak, dokunsal cihaz ile modellenmiş örgü yapısı içerisinde hangi noktaya temas edildiğinin tespiti için çarpışma tespiti yöntemi tercih edilmiştir. Çalışma kapsamında geliştirilen simülatör üzerindeki tüm benzetimler, OpenGL kütüphanesi içerisinde bulunan fonksiyonlar kullanılarak gerçek zamanlı olarak gerçekleştirilmiştir. Ayrıca simülatörden toplamda 11 acemi ve uzman kullanıcı için simülasyon geri bildirimleri toplanmış ve her bir yumuşak doku için kullanıcıların elde ettikleri operasyon süreleri karşılaştırılmıştır. Yürütülen deneysel çalışmalar ve istatiksel analizler neticesinde, geliştirilen yazılım platformunun temas tespiti, tepki kuvveti, gerçek zamanlı benzetim ve deformasyon sonuçlarının görsel olarak ve hız açısından istenilen seviyede olduğu görülmüştür.
IoT uygulamalarında çok etmenli sistemlerin (MAS) birlikte çalışabilirliğinin rolü: Akıllı üretim sistemlerindeki son gelişmeler üzerine bir araştırma
Authors: ÇALIŞ USLU Banu
Published: October 2022

Çok Etmenli Sistemler (MAS), Nesnelerin İnterneti (IoT) uygulamaları içerisinde, akıllı nesnelerin etmenler (agent) olarak tasarlanması aracılığı ile birden çok akıllı cihazdan bilgilerin algılamasını, toplamasını, paylaşmasını, pekiştirilmesini ve revize edilmesini mümkün kılmaktadır. Çok etmenli sistemler ve ilgili araçlar, sistemlerin optimizasyonunda kullanılan paradigmalar için önemli değişikliklere katkıda bulunmakla birlikte, MAS hakkındaki mevcut literatür, IoT cihazlarının gelişmiş işbirliğini açıklayan modern dağıtılmış hesaplama yöntemlerini açıklamak için yeterli düzeyde değildir. Bu araştırma, IoT içerisinde yer alan akıllı cihazların, MAS teknolojisi ile birlikte çalışabilirliği hakkında kapsamlı bir araştırma sunmaktadır. Bu kapsamda, önce etmen tabanlı sistemler ve IoT teknolojisi hakkında genel bir bilgilendirilme sunularak, çok etmenli sistemler içerisinde birlikte çalışabilirliğin önemi ve üretim sistemleri özelinde çoklu etmen teknolojisinin, sensör verilerini yakalamadan karar vermeye kadar çeşitli amaçlarla nasıl kullanılabileceğini açıklanmıştır. Çok etmenli sistemlerde birlikte çalışabilirlik için geliştirilen ve üreticiden bağımsız olarak birbirini anlayabilen iki ana dil hakkında bilgilendirme sunulmuştur. MAS'in IoT tabanlı kablosuz sensör ağında (WSN'ler) veri toplama ve entegrasyonu açıklanmıştır. Akıllı üretim sistemlerinin tasarımında, MAS'in geliştirmeye açık alanları ve gelecekteki trendlerinde IoT uygulamasını ele almak, bu makalenin bir diğer katkısı olarak sunulmuştur. Araştırmanın, IoT ve MAS üzeride çalışan araştırmacılar, tasarımcılar ve yöneticiler için bir yol gösterici olması beklenmektedir.
PCR cleanup and size selection with magnetic beads v1
Authors: Buchner Dominik
Published: October 2022

This protocol describes how to clean up PCR products or DNA extracts and perform a size selection with carboxylated-magnetic beads and a PEG-NaCl buffer. It can also be used for volume reduction of a sample or for buffer exchange.
Real-time quantitative polymerase chain reaction (RT-qPCR) v1
Authors: not provided An.Huang
Published: October 2022

Real-time quantitative polymerase chain reaction (RT-qPCR) helps determine the expression level of a certain gene by amplifying DNA according to the target mRNA template. This protocol describes the procedure of conducting RT-qPCR using Promega GoTaq® qPCR Master Mix A6001.
Effect of iron-binding polypeptides and non-starch polysaccharides supplementation on growth performance and fecal scores of weaning pigs
Authors: Talukder Jamil , Mclnerney Clare F , Nelson Kathryn L , Close Baylee C , Srivastava Ajay K , Jang Young D
Published: October 2022

Background: Weaning is the most stressful event in pig’s life, resulting in postweaning diarrhea and growth retardation. The supplementation of Advanced Digestion Enhancing Protein Plus Technology (ADEPPTTM), which contains iron-binding polypeptides and non-starch polysaccharides, to nursery diets may reduce the occurrence of diarrhea and enhance growth performance of weaning pigs. Objective: To evaluate the effect of ADEPPTTM supplementation on growth performance and fecal score in weaning pigs. Methods: At weaning, a total of 54 weaning pigs (initial body weight: 7.42 ± 0.52 kg) were assigned to 3 treatments in 3 replicates with 6 pigs per pen based on sex, breed, and body weight for a 28-d feeding trial. The pigs were fed corn-soybean meal-based diets containing 0.0, 0.5, and 1.0% of the ADEPPTTM product in 2 phases (d 0-14 and d 15-28 postweaning, respectively). In the first week (d 3-5 postweaning) of the trial, a pig was removed from each pen when diarrhea was observed, housed in a separate pen within treatment, and then treated for 3 days with a 100-ml solution of electrolytes and ADEPPTTM by drenching. Growth performance and fecal score (1=normal to 4=watery diarrhea) were measured. Results: In the feeding trial, there were no significant differences in body weight, average daily gain, and average daily feed intake throughout the overall period. However, a quadratic trend was observed in gain to feed ratio (p=0.09) for d 0-7 postweaning and overall period with increasing ADEPPTTM supplementation levels in which the greatest value was observed in the 0.5% ADEPPTTM level. The fecal score tended to decrease linearly with increasing ADEPPTTM levels during d 0-7 (p=0.11) and 0-14 (p=0.12) postweaning. There was no significant difference on fecal score of diarrheic pigs and average daily gain tended to increase linearly in d 21-28 postweaning (p=0.08) with increasing ADEPPTTM levels. Conclusion: These results indicate that 0.5% ADEPPTTM supplementation has a potential to enhance growth performance of weaning pigs and might be effective to prevent and control postweaning diarrhea.
CLOSED FORM EXPRESSIONS OBTAINED FROM THE SOLUTION OF ORDINARY DIFFERENTIAL EQUATIONS OF THE PROBABILITY DENSITY FUNCTION OF THE BETA DISTRIBUTION
Authors: Agboola Olasunmbo O. , Okagbue Hilary I. , Adedotun Adedayo F. , Ugwoke Paulinus O.
Published: October 2022

In this paper, some closed form expressions for selected parameters for the probability density function (PDF) of the beta distribution are obtained. The closed form expressions are recovered from the solution of the ordinary differential equations (ODEs), obtained from the differentiation of the PDF of the distribution. The paper shows that the shape of the distributions also determines the nature of the resulting ODE which has shown how distributions related to the beta distribution can be traced via the solutions of the ODEs. Numerical methods are unnecessary because the closed form expressions are the same with the values obtained from the standard statistical software.
On the pole indicatrix curve of the spacelike Salkowski curve with timelike principal normal in Lorentzian 3-space
Authors: AKSAN Birkan , GÜR MAZLUM Sümeyye
Published: October 2022

Bu çalışmada 3-boyutlu Lorentz uzayında timelike asli normalli spacelike Salkowski eğrisinin pol gösterge eğrisinin Frenet çatısı, eğrilikleri, Frenet türev formülleri, Darboux vektörü, yay uzunluğu, e ve (Lorentzian küre) ye göre geodezik eğrilikleri hesaplanmıştır ve bu pol gösterge eğrisi Lorentzian küre üzerinde gösterilmiştir.
Analysis of 3D-Models of Artificially Deformed Crania, Using Geometric Morphometry
Authors: Pugacheva E. V. , Uchaneva E. N. , Kazarnitsky A. A. , Gromov A. V.
Published: October 2022

The study of artificially deformed crania is complicated by difficulties in analyzing curvilinear shapes without reliable reference points for measurement. Methods of geometric morphometrics (GM) help to solve this problem. We generated 3D-models of deformed crania (26 male and 19 female) from burials of different chronological periods of the Okunev archaeological culture (Verkhniy Askiz I, Uybat III and V, Uybat-Charkov, Itkol I and II), Southern Siberia (2600–1700 BC). Using the Landmark IDAV software, each model was transformed into a set of six traditional craniometric landmarks and 450 semi-landmarks regularly distributed over the entire surface of the braincase. For further processing with the Procrustes and principal component analysis, functions of several R-packages (Morpho, Geomorph, and Arothron) were employed. Crania from early Okunev burials were found to have a small deformed area around lambda, spanning the posterior parts of parietal bones and the upper part of the occipital squama. In crania from later Okunev burials, the deformation extends on the parietal area, causing the reduction of cranial height owing to a lesser curvature of the parietal segment. The lateral walls of the braincase, the frontal squama, and the lower part of the occipital squama in such crania are more convex.
Foreword by the Editor
Authors: Tolstykh N.N.
Published: October 2022

The articles in this thematic issue of the journal present new methods of social psychology or the ones that are rarely used by domestic researchers.
Verbal and Nonverbal Strategies of Interaction between Active and Passive Smokers in Situations of Smoking in Public Places: a Method of Case Formulation
Authors: Bedina I.D. , Kochetova T.V.
Published: October 2022

Objective. Identification of the features of social perception in situations of smoking in public places, as well as patterns and strategies of interaction in the communicative practices of active and passive smokers in public urban spaces using the “case formulation” method.Background. Because of the non-compliance with the law on smoking in public places, the issue of combating such violations becomes urgent. But it is important to use not only the administrative resources of the state, but also social control. Searching for the features of communicative practices of both active and passive smokers in relation to each other, their mutual social perception and factors influencing the interaction between them will help to suggest effective ways to use social capital to combat the problem of smoking in public places.Study design. The paper studied cases related to the behavior of smokers and non-smokers in an open urban space. Using the interpretation of qualitative data, categories and subcategories corresponding to the patterns of behavior of subjects and their mutual perception from both interacting groups were identified. Categories and subcategories were formed by data encoding.Participants. For the study, 4 cases of interaction between active and passive smokers in Tverskaya Street were selected by random sampling.Measurements. The method of covert observation with a passive type of participation was chosen. 4 observation sessions were conducted the results of which formed the basis of the cases. The observation involved the study of the behavior of subjects in relation to each other, including verbal and nonverbal signs exchanged by communication participants; features of urban spaces in which communication takes place; the place of interaction.Results. Active and passive smokers use verbal and nonverbal interaction strategies, which are characterized by some features of social perception. Thus, verbal ones include an impersonal expression of discontent, an appeal to the fact of smoking, an appeal to the smell; non-verbal ones — most often motor ones: slowing down the step, accelerating the step/overtaking, as well as changing the trajectory of smoke.Conclusions. The using of the case formulation method opens up opportunities for studying various communicative practices in the modern urban environment. It is important to conduct communication campaigns aimed at both violators and people affected by their actions. The former should be encouraged to behave responsibly by the immersive transfer of “someone else’s” social experience, the victims should be mobilized to use the advantages of their existing social coercion apparatus by verbalizing demands.
PERMA-Profiler: the Approbation of the Russian Version
Authors: Isaeva O.M. , Akimova A.Y. , Volkova E.N.
Published: October 2022

Objective. Study aims to translate into Russian, to adapt and to validate a Russian version of PERMA-Profiler (Butler, Kern, 2016).Background. The topic of wellbeing and happiness gains attention in both academic publications and the business community. One of the key components for promoting wellbeing is providing a reliable measurement tool for its assessment.Study design. The translation, adaptation and validation process was subdivided into 3 stages. At the 1st stage English version of the PERMA-Profiler was translated into Russian. At the 2nd stage we assessed of the structural and convergent validity, reliability by the internal consistency of the items of the questionnaire. The main task of the 3rd stage of the study was to check the retest reliability of the PERMA-Profiler questionnaire by conducting a correlation analysis of the values of the questionnaire components obtained at the second and third stages.Participants. The main psychometric sample included 6229 participants aged between 18 and 62 years. All participants live in the Russian Federation.Method. The study used the questionnaires “Psychological Well-Being Scale” by K. Riff, “Well-being, Activity, Mood”, Subjective Feeling of Loneliness Scale by D. Russell, L. Peplo, M. Ferguson, “Life Satisfaction Scale” by E. Diner. Correlation analysis, confirmation factor analysis, analysis of scales by internal consistency and the half method were used for data processing and analysis cleavage.Results. The expected structure of the PERMA-Profiler questionnaire was confirmed. The scales of PERMA-Profiler had sufficient reliability and validity.Conclusions. PERMA-Profiler well-being questionnaire can be used for sociological, psychological and interdisciplinary studies of the psychological well-being of the individual.
Attitudes Towards Physical Disability Scale Adaptation on a Russian Sample
Authors: Romanova M.O. , Kozhan E.A. , Bykov A.O. , Efimova L.A. , Asadullina A.F.
Published: October 2022

Objective. The Attitudes to Physical Disability Scale (ADS) adaptation.Background. Opinion polls show that in Russia perception of people with disabilities is complex and ambiguous. However, there is still no reliable method for measuring attitudes towards disability in Russia, but attitudes influence people with disabilities’ well-being and their inclusion.Study design. We conducted 2 studies. Within study 1 the original scale items were translated, tested at the stages of cognitive interviews and web-probing and corrected. Then a survey containing only the translated scale was conducted. In study 2 additional scales were included in the questionnaire in order to check the construct validity of the ADS.Participants. Study 1 sample included 627 respondents (45,6% men, Mage=35.99). Study 2 sample included 738 respondents (45,8% men, Mage=36.21).Measurements. During the research a series of cognitive interviews, web-probing and 2 surveys were conducted. Attitudes to Physical Disability Scale, social dominance orientation scale, just world belief scale and «Big Five Inventory» were used.Results. EFA results revealed the 3-factor structure of the Russian ADS version. CFA results indicated that the model has a good fit. Correlation analysis results proved scale construct validity, while high Cronbach’s α score proved its internal consistency.Conclusions. Russian ADS version proved to be a reliable and valid tool for investigating attitudes towards people with disabilities in Russia.
Scientific Reflection on the Development of Academic Social Psychology (to the 50th Anniversary of the IP RAS and the 100th Anniversary of the Birth of E.V. Shorokhova)
Authors: Semenov I.N. , Vodopianov D.A.
Published: October 2022

Objective. Against the background of the analysis of the history of social psychology, to study the specifics of its academic research at the IP RAS and the role of E.V. Shorokhova in their organization, characterizing her scientific life.Background. In connection with the 50th anniversary of the country’s leading scientific center for experimental psychological research — the Institute of Psychology of the Russian Academy of Sciences — the article analyzes the scientific and organizational activities of the IPAN Deputy Director, head of the laboratory of social psychology, one of the founders and leaders of Soviet and post-Soviet social psychology, Professor E.V. Shorokhova, whose 100th birthday is celebrated by the scientific community this year. The relevance of the article is related to the need to study the history of Soviet social psychology as a historical and scientific basis for studying the existing prerequisites and explicating the logic of the development of socio-psychological knowledge in order to determine its future prospects in modern socio-cultural conditions. The novelty of the article is determined by the scientific methods of the institutional and personological analysis of the heritage and the construction of the periodization of E.V. Shorokhova as an authoritative enthusiast of the country’s first post-war socio-psychological research and one of the organizational leaders of their further development during the «Thaw» at the Institute of Philosophy of the USSR Academy of Sciences and then at the Institute of Psychology of the USSR Academy of Sciences/RAS during periods of «Stagnation», «Reconstruction» and modern democratization society.Conclusions. This article shows for the first time the periodization of the life stages of E.V. Shorokhova, their existential-institutional significance and scientific-subject content are shown, which had a strategic impact on the organization of a complex of socio-psychological research at the IP RAS.
Antifungal Activities of Essential Oils from Protium ovatum Engl. Against Malassezia furfur and Candida Species
Authors: Rodrigues Gardênia Barbosa Carrijo , Fernandes Cassia Cristina , Marcionilio Suzana Maria Loures de Oliveira , Castro Vitor de Paula , Alvarez Carmen Magaly , Pires Regina Helena , Santiago Mariana Brentini , Pedroso Reginaldo dos Santos , Martins Carlos Henrique Gomes , Miranda Mayker
Published: October 2022

Fungal opportunistic infections have increased in recent decades due to the increase in the immunosuppressed patients and the indiscriminate use of antifungals. In Brazil, a country with the greatest biodiversity in the world, studies that seek new antifungals from natural sources have been stimulated. Protium ovatum Engl., belongs to the Burseraceae family and is a shrub tree found mainly in Brazil, in the Cerrado biome, and has medicinal, food and aromatic uses. This study aims to investigate the chemical composition and the anti-Malassezia furfur and anticandidal activities of essential oils (EOs) from Protium ovatum ripe fruit (RF-EO) and unripe fruit (UF-EO). The EOs antifungal activities were determined by microdilution broth methodology. GC-FID and GC-MS analyses showed that limonene, α-pinene and myrcene were the major components of both EOs. MIC values of RF-EO and UF-EO against M. furfur were 375 and 1500 µg/mL, respectively. RF-EO exhibited MIC values between 62.5 and 250 µg/mL while UF-EO was slightly active (> 1000 µg/mL) against Candida species. In addition, RF-EO showed antibiofilm activity against Candida species and was not toxic to C. elegans larvae. This study suggests that EOs from P. ovatum could be an alternative therapeutic option for infectious diseases caused by M. furfur and Candida species.
Human dirofilariosis (D.repens) in the subcutaneous tissues of the head: Clinical case in the department of neurosurgery of the Interregional Clinical and Diagnostic Center of Kazan
Authors: Pichugin Arseniy
Published: October 2022

Human Dirofilariasis is a zoonosis caused by thin nematodes of Dirofilaria species (D. repens, D. immitis, D. tenuis и D. Ursi) that belong to the Onchocercidae family. Larval stages of Dirofilaria are usually occur in their primary hosts like cats and dogs and rarely invade incidental hosts - human.
In the article described a clinical case of a patient with skull base meningioma who was admitted to the neurosurgical department for elective surgical treatment. The dense nodule was palpated in the subcutaneous tissue of the frontal area of the head. While removing the subcutaneous node a thin white alive worm was evacuated during the surgery. The microscopical examination verified D. repens.
Human Dirofilariasis is a rare disease in the Republic of Tatarstan, Russia. However, there is observed a growth of the number of dirofilariasis cases in the recent years. Nine patients with dirofilariasis were diagnosed in the Republic of Tatarstan within 2019-2022.
Features of immunological reactivity in Sami women
Authors: Samodova Anna V. , Dobrodeeva Liliya K. , Balashova Svetlana N. , Pashinskaya Ksenia O.
Published: October 2022

BACKGROUND: The Sami are a small group of indigenous people of the Russian Federation. The Sami have one of the lowest birth rates among all the peoples of the North of Russia. They often have more health problems than residents of other nationalities in the Murmansk region, due to a high incidence of acute respiratory infections. Extreme climatic and geographical conditions of the Arctic have a negative impact on immunological reactivity.
AIM: To identify the features of immunological reactivity in Sami women.
MATERIALS AND METHODS: Forty-nine practically healthy Sami women aged from 21 to 44 years living in the Lovozero Village in the Murmansk region were examined. A control group consisting of 50 practically healthy Russian women of the Arkhangelsk region of the same age range was used. The hemogram, phagocytic activity of neutrophils of peripheral venous blood, and the content of lymphocytes with CD3, CD4, CD8, and CD10 phenotypes were studied by indirect immunoperoxidase reaction (Sorbent, Moscow) and flow cytometry (Beckman Coulter Immunotech, France). Additionally, concentrations of IgM, IgG, IgA, sCD54, and sCD62L (Bender MedSystems, Austria) were determined by enzyme immunoassay, circulating immune complexes (CIC) were determined by the precipitation method. The total amount of microflora, cytogram, phagocytic activity of neutrophils, the sorption capacity of epithelial cells, the content of sIgA and CIC IgG were studied in the separated mucous membranes of the pharynx, intestines, and urine. For comparison between groups, the independent samples t-test or the nonparametric MannWhitney U-test was used depending on the distribution.
RESULTS: In Sami women, the frequency of deficiency of phagocytic activity of blood neutrophils and mucosal secretions was higher than in the control group. Increased reactions of cell-mediated and antibody-dependent cytotoxicity of lymphocytes were recorded. The frequency of elevated concentrations of CIC was higher in the Sami women than in the control group. A remarkable feature of the Sami immune reactivity was high concentrations of IgA and IgM against a background of low IgG content.
CONCLUSION: In Sami women, the percentage of actively phagocytic neutrophil granulocytes of peripheral venous blood and mucous membranes was lower than in the control. A distinctive feature of the immunoglobulin profile of the blood serum of Sami women was the low IgG content against the background of increased concentrations of CIC, including immunoglobulins of this class. Sami women had higher levels of leukocyte migration into mucosa-associated mucosal tissue, which was correlated with a decrease in the sorption capacity of epitheliocytes, phagocytic activity of neutrophils, and concentrations of secretory immunoglobulins.
Prospects of Hyaluronidase Therapy in Novel COVID-19 Infection with Damage to Lungs
Authors: Solov’yeva Aleksandra V. , Korshunova Ludmila , Shurpo Ekaterina , Namestnikova Anastasia
Published: October 2022

INTRODUCTION: In recent years, the production and regulation of synthesis of hyaluronic acid in COVID-19 has been actively studied. Hyaluronan plays a significant role in development of severe lung damage in COVID-19 and is a potential therapeutic target the action on which will probably improve prognosis for patients with COVID-19.
AIM: To study prospects of using bovhyaluronidaze azoximer in complex treatment of patients with COVID-19 with lung damage at the inpatient stage.
MATERIALS AND METHODS: Thirty five patients (6 men and 29 women) aged 58.9 12.9 years hospitalized with COVID-19 infection, were examined. Capillary blood saturation (SpO2) was 80.1 8.6%, the volume of lung damage in X-ray computed tomography (X-ray CT) was 45.1 19.4% on the right and 40.0 19.5% on the left. All the patients received treatment according to the Temporary Guidelines: prevention, diagnosis and treatment of novel coronavirus infection. Ver. 14 (27.12.2021). Besides, as part of complex treatment for COVID-19, bovhyaluronidaze azoximer was administered intramuscularly on the 21.9 6.8th day of illness with a course of 10 injections (once in 3 days).
RESULTS: In the course of comprehensive treatment including bovhyaluronidaze azoximer, increase in SpO2 was recorded: in 7 patients ― after 1 injection (4.2 1.7%), in 24 ― after 2 injections (5.4 0.6%), another 4 patients did not show any significant increase in SpO2 after the first two injections. Increase in SpO2 after the 1st injection inversely correlated with age (r = -0.34; p 0.05) and the initial saturation (r = -0.38; p 0.05). Increase in SpO2 after the second injection correlated with the day of illness on which treatment with bovhyaluronidaze azoximer began (r = -0.36; p 0.05).
CONCLUSION: Use of bovhyaluronidaze azoximer in complex treatment for COVID-19 with the lung damage at the inpatient stage can be effective in younger patients with more expressed initial reduction of SpO2, and also in case of administration of the drug in the early stages of the disease. The data obtained in the pilot study, dictate the necessity of studying the level of hyaluronic acid in blood of patients with COVID-19 and lung damage and its role in risk stratification of such patients.
Study of Electrophysiological Properties of Atrioventricular Node in Permanent Cardiac Pacing under Influence of Trimetazidine Dihydrochloride
Authors: Smirnov Vasiliy N. , Staroverov Il’ya N. , Gridin Aleksandr N.
Published: October 2022

INTRODUCTION: Dual-chamber cardiac pacing permits to maintain permanent atrial-ventricular synchronization. Physiological sequence of propagation of the impulse from atria to ventricles is provided with an artificial delay analogous to delay of propagation of excitation through the atrioventricular (AV) node of a heathy individual. The delay interval is formed so that to minimize stimulation of the right ventricle. This preserves the left ventricular ejection fraction, reduces the risk of development of the chronic heart failure (CHF) and of atrial fibrillation, and increases functional abilities of the patient. On the other hand, critical increase in the atrioventricular delay leads to pacemaker syndrome: impairment of circulation function, shortness of breath, reduced tolerance to exercise, dizziness, syncopal state. The question of the influence of the permanent electrical pacing on the AV node conduction remains unsolved.
AIM: To study the effect of trimetazidine dihydrochloride on the AV node conduction in conditions of permanent cardiac pacing, to determine the effect of cardiac pacing on the AV node in the studied time period.
MATERIALS AND METHODS: The study involved 86 patients. The AV node activity was assessed by antegrade intraoperative determination of Wenckebach point on the basis of electrocardiography data in 2448 hours after pacemaker implantation, in 68 hours, 7, 14, 9 and 180 days after intake of trimetazidine dihydrochloride and in 7, 14, 21 and 30 days after its cancellation. To compare the extent of influence of the studied drug on the AV node activity, the patients were divided to three groups depending on the basic pathology: group 1 ― patients with the sick sinus node syndrome (n = 38, 44.2%); group 2 ― patients with II degree AV block (n = 25, 29.1%); group 3 ― patients with III degree AV block (n = 23, 26.7%).
RESULTS: Trimetazidine dihydrochloride improved the electrophysiological properties of the AV node in the first and second groups: increase in the mean value of Wenckebach point antegrade in the first group was in total 3.26% (р = 0.022), in the second group 4.68% (р = 0.001). In the third group of patients no improvement was noted, but it should be said that under the action of this drug, in 4 of 23 patients with III degree AV block, antegrade AV conduction appeared (р = 0.236).
CONCLUSION: Trimetazidine dihydrochloride has a positive effect on the AV node activity as early as in 68 hours of intake, which reaches maximum in 3 weeks. Cardiac pacing had no effect on AV node within the follow-up period (6 months).
Intracellular Location and Function of Nuclear Factor of Erythroid Origin 2 (Nrf2) in Modeling Oxidative Stress in vitro
Authors: Abalenikhina Yuliya V. , Erokhina Pelageya D. , Seidkuliyeva Adamiana A. , Zav’yalova Ol’ga A. , Shchul’kin Aleksey V. , Yakusheva Elena N.
Published: October 2022

INTRODUCTION: Nuclear factor E2-related factor 2 (Nrf2) is a member of capncollar (CNC) family of subfamily of leucine zipper transcription factors that regulates cell protection against toxic substances and oxidants.
AIM: To determine location, mechanism of activation and role of Nrf2 in conditions of oxidative stress in vitro.
MATERIALS AND METHODS: The study was performed on human colon adenocarcinoma cell line (Caco-2). Oxidative stress (OS) was modeled by adding hydrogen peroxide (Н2О2) at concentrations of 0.1 М100 М to the nutritive medium and incubation for 24 and 72 hours. In assessment of Nrf2 function, its inhibitor ― AEM1 ― was added to cells at a concentration of 5 М. The extent of OS development was determined using photometric methods by the concentration of protein SH-groups and carbonyl derivatives of protein, and the activity of superoxide dismutase (SOD). Viability of cells was assessed by the results of cytotoxic test (MTT assay), the amount of Nrf2 in the cytoplasm and nucleus was determined by heterogenous ELISA method.
RESULTS: Incubation of Caco-2 cells with Н2О2 resulted in decrease in the level of protein SH-groups and increase in the concentration of carbonyl derivatives of protein. In incubation with H2O2 at concentrations of 0.1 М10 М for 24 hours and 10 М for 72 hours, the activity of SOD increased. At concentrations of Н2О2 of 50 М and 100 М (24 hour and 72 hour), SOD activity and viability of cells decreased. Exposure to Н2О2 led to translocation of Nrf2 from the cytoplasm into nucleus. Direct correlation dependence was revealed between concentration of protein SH-groups and the amount of Nrf2 in the cytoplasm in incubation with H2O2 for 24 hour (r = 0.44, р = 0.03), 72 hour (r = 0.34, р = 0.05). The amount of Nrf2 in the nucleus positively correlated with SOD activity in the cytoplasm on exposure to H2O2 for 24 hour (r = 0.77, р = 0.0001) and 72 hour (r = 0.36, р = 0.06). In inhibition of Nrf2 in conditions of exposure to H2O2, the viability of cells decreased to a larger extent.
CONCLUSION: Hydrogen peroxide induces the nuclear translocation of Nrf2, which promotes activation of antioxidant enzyme SOD and preserves viability of cells of OS conditions in vitro.