bluuebunny/crossref_metadata_2025 huggingface dataset:
La psicológía de Henri Wallon y su relevancia para el estudio del trabajo y de la actividad
Authors: Maestro Juan Ignacio Castien
Published: March 2021

La obra de Henri Wallon (1879-1962) representa un valioso esfuerzo por construir una psicología materialista y dialéctica. Apesar de todo este potencial, la psicología walloniana disfruta hoy en día de una popularidad bastante inferior a la de otras psicologías también de raigambre marxista como el freudomarxismo y la escuela de Vygotsky. En este breve artículo pretendemos contribuir a un mejor conocimiento de la misma, así como destacar su fecundidad para el estudio de la naturaleza y la génesis de diversos tipos de actividad humana como el juego, el arte, el ritual mágico-religioso, la ciencia y el trabajo. Centrándonos en el trabajo, entendido en un sentido moderno, éste difi ere de otras formas históricamente anteriores de actividad laboral, por su mayor objetividad y su menor emotividad. La objetividad puede entenderse en un sentido cercano al de la descentración de Piaget, como una distinción entre el sujeto y el mundo objetivo sobre el cual actúa aquél. Estas cualidades son el resultado de un largo proceso histórico. La teoría de Wallon sobre la imitación, como vehículo para la construcción de las emociones y del conocimiento objetivo de uno mismo y del medio, puede iluminar algunos aspectos de este complejo proceso.
A hipótese comunista [Alain Badiou]
Authors: Cicero Pedro Henrique de Moraes
Published: March 2021

Relativizar as consequências e o peso do “fracasso”. Esse é o objetivo estabelecido pelo fi lósofo Alain Badiou ao compilar em livro ensaios que tratam o comunismo como “a hipótese histórica de um mundo livre da lei do lucro e do interesse privado”.
Apresentação
Authors: Editorial Comitê
Published: March 2021

Apresentação do Cadernos Cemarx n° 9 - Dossiê: " A atualidade do pensamento de Ruy Mauro Marini"
A democracia e a universalização do ensino fundamental
Authors: Nogueira Francis Mary Guimarães , Borges Liliam Faria Porto
Published: March 2021

A divulgação do MEC em 2001 de que havíamos universalizado o Ensino Fundamentalcom o índice de ingresso e permanência de 96,3% das crianças em idade escolar, e arepercussão política deste fato na academia, e em segmentos importantes de professoresque militaram política e teoricamente em defesa da Universalização da Educação Básicanos anos 70 e 80, esteve marcada por um tom de frustração e desolamento. A reaçãoexpressou-se em publicações e palestras proferidas em fóruns educacionais, revelando anegação das estatísticas sobre as conquistas que viabilizaram a universalização.
Expressão do conflito de classe na concepção de educação profissional no Brasil contemporâneo
Authors: Souza José dos Santos
Published: March 2021

Trataremos aqui aspectos teóricos dos diferentes discursos acerca da formação profissional nos anos 90. Para isso, tomamos como referência a teoria da práxis material em Marxcomo categoria analítica básica e seus pressupostos; são eles: 1) o trabalho como categoria central e determinante do processo histórico; 2) o trabalho como possibilidade de emancipação e desenvolvimento das potencialidades humanas; e 3) a possibilidade de supe-ração da alienação do trabalho através da construção de uma nova hegemo-nia fundada na conscientização de classe e na luta pela superação das rela-ções sociais de produção capitalista.
Aprendizagem com entretenimento através do youtube
Authors: Spindola Raila
Published: March 2021

A Cultura da Convergência está transformando o modo como vivemos, convivemos, aprendemos e ensinamos. Este artigo realiza a análise de conteúdo de dois vídeos do canal no Youtube Nerdologia, que aborda temáticas científicas utilizando referências à cultura pop. Também foram analisados os comentários dos espectadores do programa e as respostas dos produtores, em busca de compreender como é a interação do público e de que maneira o formato do canal contribui para o aprendizado em conjunto. Como base para o tratamento dos resultados obtidos, foram utilizados os conceitos de Henry Jenkins para Comunidades de Conhecimento e Letramento Midiático, abordados em sua obra Cultura da Convergência (2009).
Produção de memes como campanha contra as fake news
Authors: Melo Keite Silva de , Silva Andréa Villela Mafra da , Rodrigues Valéria Ribeiro , Gonçalves Margareth da Silva Miranda
Published: March 2021

O presente trabalho possui por objetivo apresentar uma experiência de ativismo político, por meio da produção criativa de memes, como forma de enfrentamento ao problema das fake news. Esta experiência ocorreu no segundo semestre de 2018, com alunos do curso de Pedagogia do Instituto Superior de Educação do Rio de Janeiro, que produziram memes para veicular em suas redes sociais, como uma campanha político-educativa. A apropriação dos distintos gêneros discursivos, bem como a imersão na rede com o letramento digital desenvolvido é urgente a todos, mas aos futuros professores, trata-se de uma urgência ainda maior. A associação da criatividade, autoria e ativismo, possibilitou a estes licenciandos, ultrapassarem a cultura do compartilhamento detido no mero consumo, para promover visibilidade da sua própria autoria.
COVID-19 PANDEMİSİNDE GÖREV ALAN SAĞLIK ÇALIŞANLARININ ALGILADIKLARI SOSYAL DESTEĞİN DEPRESYON, ANKSİYETE VE STRES DÜZEYLERINE ETKİSİ
Authors: ÖZTÜRK Mehmet , TUNCER ERTEM Gunay , KOTANOĞLU Mustafa Sırrı , ERDİNÇ Şebnem , KINIKLI Sami
Published: March 2021

Amaç: Pandemi sürecinde görev alan sağlık çalışanlarının algıladıkları sosyal desteğin depresyon, anksiyete, stres düzeyleri ile arasında ilişki olup olmadığının saptanması ve ilişkili ise hangi faktörler ile ne düzeyde ilişkili olduğunun belirlenmesi amaçlanmıştır. Gereç ve Yöntem: S.B.Ankara Eğitim ve Araştırma Hastanesinde pandemi ile ilgili birimlerde görevlendirilen doktor ve hemşire/sağlık memurundan oluşan 197 kişi çalışmaya alınmıştır. Örneklem grubuna sosyodemografik veri formu, DASS-42 ve ÇBASDÖ uygulanmıştır. Bulgular: 197 katılımcının; %58,4’ü doktor, %41,6’sı hemşire/sağlık memuru, %65’i kadın, %50’si evli ve %40,4’ü COVID-19 servisinde, %24,1’i acil serviste, %22,3’ü COVID-19 yoğun bakım servisinde %11,2’si COVID-19 polikliniğinde çalışıyordu. Orta ve ileri düzeyde depresif belirti gösteren sağlık çalışanı oranı %53,3, anksiyete belirtisi gösterenler %53,8 ve stres belirtileri gösterenlerin oranı ise %48.7 di. Hemşirelerin doktorlardan istatistiksel olarak anlamlı düzeyde yüksek depresyon (p=0,041), anksiyete (p=0,013) ve stres puanlarına sahip oldukları (p=0,009), kadınların erkeklerden DASS-42 tüm alt ölçeklerinde istatistiksel olarak daha yüksek puan aldıkları saptandı. Haftalık çalışma süresi arttıkça depresyon puanlarında artış olduğu (p=0.012), 24 saatin üstünde haftalık çalışma saati olanlarda anksiyete düzeyleri yüksek bulundu (p
DEVELOPMENT OF ALGORITHM OF SMART GEOGRAPHIC AREA
Authors: S.I Yusifov , N.A Ragimova , V.H Abdullayev , M.E Khalilov
Published: March 2021

The rapid development of information technologies accelerates the approximations of industry 4.0, which is why sectors of the economy and science must adapt to these changes. Global changes in geography have led to the emergence of a new scientific discipline called geoinformatics. It then provides insight into the Smart Geographic Area, its structure and the main components. To do this, there used methods for communicating the main components IIoT, IoE), for analyzing data (Big Data, Hadoop), for managing processes (CPs), for storing data (Cloud Computing, Fog Computing). As a result of the study, there was developed a Smart Geographic Area algorithm based on the MapReduce paradigm.
Deep Learning Feature Extraction for Brain Tumor Characterization and Detection
Authors: Basir Otman , Shantta Kalifa
Published: March 2021

Deep Learning is a growing field of artificial intelligence that has become an operative research topic in a wide range of disciplines. Today we are witnessing the tangible successes of Deep Learning in our daily lives in various applications, including education, manufacturing, transportation, healthcare, military, and automotive, etc. Deep Learning is a subfield of Machine Learning that stems from Artificial Neural Networks, where a cascade of layers is employed to progressively extract higher-level features from the raw input and make predictive guesses about new data. This paper will discuss the effect of attribute extraction profoundly inherent in training approaches such as Convolutional Neural Networks (CNN). Furthermore, the paper aims to offer a study on Deep Learning techniques and attribute extraction methods that have appeared in the last few years. As the demand increases, considerable research in the attribute extraction assignment has become even more instrumental. Brain tumor characterization and detection will be used as a case study to demonstrate Deep Learning CNN's ability to achieve effective representational learning and tumor characterization.
Volumetric Bone Mineral Density in Cementless Total Hip Arthroplasty in Postmenopausal Women
Authors: Aro Hannu T. , Engelke Klaus , Mattila Kimmo , Löyttyniemi Eliisa
Published: March 2021

Background:

In cementless total hip arthroplasty, femoral stems should preferably not migrate at all postoperatively. This goal is difficult to achieve in postmenopausal women with impaired bone quality. Here, we explored the clinical importance of initial stem migration, measured by radiostereometric analysis (RSA), in women who underwent quantitative computed tomography (CT) of the involved hip preoperatively.

Methods:

A prospective cohort of 65 postmenopausal women (mean age, 69 years) with hip osteoarthritis and Dorr type-A or B femoral anatomy underwent total hip arthroplasty with implantation of a tapered, single-wedge femoral stem. Volumetric bone mineral density (BMD) was measured using quantitative CT. Femoral stem translation and rotation were measured using model-based RSA within 3 days after the surgical procedure and were repeated at 3, 5, and 11 months. Postoperative recovery parameters included walking speed, walking activity, and patient‐reported outcome measures. Subjects were categorized into 2 groups according to the magnitude of initial 5-month stem subsidence (<2 mm or ≥2 mm); RSA outliers (n = 7) were analyzed separately.

Results:

Subjects with stem subsidence of ≥2 mm (mean, 3.09 mm [95% confidence interval (CI), 2.70 to 3.47 mm]) had lower intertrochanteric volumetric BMD (p = 0.008). Subjects with subsidence of <2 mm (mean, 0.80 mm [95% CI, 0.51 to 1.09 mm]) had faster improvement of patient‐reported outcome measures and exhibited faster walking speed (p = 0.007) and greater walking activity (p = 0.010) at 11 months as well as better Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores (p = 0.002) and RAND 36-Item Health Survey mental component scores (p = 0.006) at 2 years. All cohort stems were osseointegrated at 2 years.

Conclusions:

Femoral stem stability and resistance to subsidence were sensitive to adequate intertrochanteric volumetric BMD. Low intertrochanteric volumetric BMD was associated with greater stem migration. With initial migration, clinical recovery was slower and patient-reported outcome measures were less satisfactory.

Level of Evidence:

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
A Study on the Relationship Between Land Finance and Housing Price in Urbanization Process: An Empirical Analysis of 182 Cities in China Based on Threshold Panel Models
Authors: Hu Meiting , Dong Jichang , Yin Lijun , Meng Chun , Li Xiuting
Published: March 2021

Scholars have a variety of theoretical explanations for housing price growth. However, few scholars have studied the internal influence mechanism among urbanization, land finance, and housing price. Based on the data of 182 prefecture-level cities from 2009 to 2016, this paper studies the influence of land finance on housing price under different urbanization rate levels. The study finds that with the increase of urbanization rate, the effect of land finance on housing price presents a “U” shape. Specifically, an increase in land finance by 1% results in a corresponding increase in average housing price by 0.18%, with relatively low urbanization rate, 0.06% with medium level of urbanization rate, and 0.38% with high level of urbanization rate.
The urgency of vaccination against Covid-19 in dentists
Authors: Arriola Guillén Luis Ernesto
Published: March 2021

The requirement of vaccines for the prevention of Covid-19 has become one of the health priorities of different countries worldwide (1, 2). However, most societies still do not have the necessary number of vaccines to cover their entire target population (3, 4). This is especially true in countries that delayed negotiations with the supply companies, and which will, unfortunately, have to wait a long time for the arrival of sufficient quantities to protect their populations. On theother hand, the global vaccination process has established priority levels among its citizens, specifically starting with the so-called first line of action that is health professionals attending Covid-19 patients, due to the great risk to which they are exposed. Additionally, the health organizations of the different countries have proposed to continue the vaccination process according to different criteria, one being the risk levels of the professions. This criterion is aimed at prioritizing professionals most exposed to contagion, but according to their daily practice, what professionals are really the most exposed to contagion?
Positioning in Personal Games: Perspectives of the Author-Player Persona in Memoir En Code: Reissue
Authors: Henderson Thryn
Published: March 2021

In creating autobiographical narratives through games, there exists a new theoretical problem in the game-player tension: how may a game creator relate their own story through a medium that relies primarily on another (the player) to execute? The blurring and shifting lines between the game creator and player resemble the same death knell Roland Barthes sounds for the literary Author in “La mort de l’auteur” (1967). This paper proposes a more nuanced theory for understanding the ‘player positioning’ of autobiographical games with a triangulated framework. The player position is a player/author persona collaboration that facilitates a shared presence in the game space through various ratios of three positions: the player as the protagonist, protagonist-proxy, and witness. Through a close reading of the autobiographical game Memoir En Code: Reissue by Alex Camilleri, the paper explores how the player may perceive the autobiographical game. Viewed through the protagonist, protagonist-proxy, and witness lens, the paper interrogates how the player position alters the nature of player-author identity within the game. It offers an approach for considering how the different perspectives of the author-player persona offer meaningful game(play), and argues for the shifting presentation of the author-player persona as an effective negotiation of a shared experience in the design of autobiographical games.
Simultaneous determination of C4-C9 alkylphenols and bisphenol A in environmental water at the Yellow River Estuary Area in China by gas chromatography-mass spectrometry
Authors: yin hailliang , ZHOU Tongna , guo ziqi , liu xinliang , ZHAO jian
Published: March 2021

A liquid-liquid extraction combined with derivatization and gas chromatography-mass spectrometry (GC-MS) method was developed for the rapid determination of C4-C9 alkylphenols (4-tert-butylphenol, 4-n-butylphenol, 4-n-pentylphenol, 4-n-hexylphenol, 4-n-heptylphenol, 4-n-octylphenol, 4-tert-octylphenol, 4-n-nonylphenol and 4-nonylphenol) and bisphenol A in the environmental water. The extraction solvent, extraction time, solvent volume, acidity, salt content and the distillation degree were optimized. After drying and dehydration, the extract was derivatized, detected by GC-MS and quantified by internal standard method. After the dehydration, the extract was derivatized with BSTFA, detected by GC-MS and quantified by internal standard method. The results showed that the relative standard deviations of the relative response factors of the target compounds were less than 20%, the method detection limits were 0.002 µg/Lཞ0.006 µg/L, the relative standard deviations of the three spiked levels were 0.67%ཞ13.7%, and the average recoveries of the actual water samples were 68.0%ཞ122%. The method precision and accuracy were good. The method is simple, rapid, accurate, stable and reliable, which is suitable for the detection of target in water. The contents of C4-C9 alkylphenols and bisphenol A in groundwater, surface water, sewage, waste water and sea water samples in Dongying City located at the Yellow River Estuary were determined by this method. The results showed that the contents of 4-nonylphenol and bisphenol A in these samples were lower than the home and abroad requirements.
Invasion of Ceratium furcoides in subtropical lakes in Uruguay: environmental drivers and first fish kill record
Authors: Esnal Juan Pablo Pacheco , Frizzera Carlos Iglesias , Goyenola Guillermo , de-Mello Franco Teixeira , Fosalba Claudia , Baattrup-Pedersen Annette , Meerhoff Mariana , Jeppesen Erik
Published: March 2021

The invasive freshwater dinoflagellate Ceratium furcoides is extending its distribution in South America with increasing environmental impacts associated with its blooms. We here report two events related to C. furcoides distribution expansion in Uruguay: 1) the first appearance and main environmental drivers (physico-chemical variables, extreme wind events and zooplankton composition) of the bloom of C. furcoides in 2012 in a subtropical eutrophic shallow lake (Lake Blanca, Uruguay), and 2) the fish kill event of Prochilodus lineatus likely caused by C. furcoides in 2016 in a deep eutrophic lake (Puente de las Americas, Uruguay), which is the first fish kill attributable to C. furcoides registered in the world. The bloom of C. furcoides in Lake Blanca started in spring 2012 (October) during a clear water period with high phytoplankton species replacement after a cyanobacterial bloom of Raphidiopsis raciborskii. Extreme wind events during this period resuspended cysts from the sediments, which likely started the C. furcoides bloom. High nutrient availability and low zooplankton grazing, allowed the bloom to expand and reach 96% of the phytoplankton biomass. Our results further indicate that the fish kill of Prochilodus lineatus in Lake Puente de las Americas was likely promoted by the high biomass of C. furcoides bloom, causing gill damage and clogging together with oxygen depletion in the benthic zone. Our study is the earliest record of C. furcoides in Uruguay and it shows the drastic consequences of C. furcoides bloom in freshwaters and its potential of inducing massive fish kills.
Comparison laboratory data between children with Kawasaki Disease and COVID-19
Authors: Liu Xiaoping , Huang Ying-Hsien , Tsai Yuh-Chyn , Liu Shih-Feng , Kuo Ho-Chang
Published: March 2021

Background: The 2019 coronavirus disease (COVID-19) has been an emerging, rapidly evolving situation in China since late 2019 and has even become a worldwide pandemic. The first case of severe childhood novel coronavirus pneumonia in China was reported in March 2020 in Wuhan. The severity differs between adults and children, with lower death rates and decreased severity for individuals under the age of 20 years old. Increased cases of Kawasaki disease (KD) have been reported from New York City and some areas of Italy and the U.K., with almost a 6-10 times increase when compared with previous years. We conducted this article to compare characters and laboratory data between KD and COVID-19 in children. Methods: We obtained a total of 24 COVID-19 children from the literature review and 234 KD cases from our hospital via retrospective chart review. Results: We found that patients with KD had higher levels of white blood cell (WBC), platelet, neutrophil percentage, C-reactive protein (CRP), procalcitonin, Aspartate Aminotransferase (AST), and body temperature, while patients with COVID-19 had higher age, hemoglobin levels, and lymphocyte percentage. After performing multiple logistic regression analysis, we found that age, WBC, platelet, procalcitonin, and AST provide identical markers for distinguishing COVID-19 from KD in children. Conclusion: In this COVID-19 pandemic period, clinicians should pay attention to children with COVID-19 infection when high WBC, platelet, procalcitonin, and AST values are present in order to provide precision treatment with intravenous immunoglobulin (IVIG) for KD or multisystem inflammatory syndrome in children (MIS-C).
Is Eating Pathology Prevalent Among Social Media Users of Karachi, Pakistan ? A Cross-sectional Study
Authors: Zahid Ibrahim , Jamali Munira , Alam Sheena Nadeem , Hassan Wajih Ul , Zafar Osama , Waseem Hira Fatima
Published: March 2021

Objective: Social media has been known to influence eating habits especially amongst children and adolescents. However, substantive literature is not present that thoroughly investigates a correlation between eating disorder pathology and the use of social media applications for male and female subjects, especially in a developing country like Pakistan. This study aims to investigate and compare the effects of social media on eating disorder pathology development in young male and female Pakistanis and analyze what factors (frequency of use, type of application, content etc) increase eating disorder pathology risk amongst them. Results: The mean age of the sample was 21.1±2.6 years. A positive correlation was seen between excessive use of social media and the risk of ED pathology. High EDE-Q scorers used social media everyday and acknowledged social media pressure to stay thin. However no statistically significant differences were seen amongst male vs female subjects. Social media usage correlated with developing BID and ED pathology amongst young Pakistani users. However further investigated is warranted in other populations to reach a more substantive conclusion.
Medication-related Knowledge, Administration Practice and Adherence Among Caregivers of Chronically Ill Children in Malaysia
Authors: Chew Chii-Chii , Chan Huan-Keat , Chang Chee-Tao , HSS Amar-Singh , HASSALI Mohamed azmi
Published: March 2021

Background: Caregivers’ knowledge, practice and adherence in medication administration who care for children with chronic illness requiring long-term pharmacological treatments are factors associating with children medication safety at home. This study aimed to determine the medication-related knowledge, administration practice and adherence among caregivers of chronically ill children in Malaysia. Methods: This cross-sectional study was conducted at the paediatric outpatient clinic of a tertiary public hospital. Caregivers of chronically ill children, who engaged in medication administration at home for at least 3 months, were conveniently recruited. Their medication-related knowledge and administration practice were evaluated based on a checklist, while their adherence to medication administration was assessed using a validated 5-point scale. The associated factors were also explored. Findings: Of the 141 participants, most were mothers (90.8%) and had a full-time job (55.3%). Most of them had adequate medication-related knowledge (71.6%) and an appropriate administration practice (83.0%). The majority of them (83.0%) also rated themselves as adherent to medication administration. The participants with a child above 5 years of age (91.2%) were found to have a better practice than those with younger children (75.3%) in medication administration (p=0.012). However, those with a child taking two (adjusted OR: 12.53) or three (adjusted OR: 8.29) medications, getting their refills from private health institutions apart from this hospital (adjusted OR=7.06) and having multiple illnesses (adjusted OR=21.25) were more likely to be not adherent to medication administration. Conclusion: Caregivers of chronically ill children in Malaysia generally have sufficient knowledge and an appropriate practice of medication administration at home. Yet, strategies to improve the adherence to medication administration, particularly in those who care for children with complicated health conditions, are warranted.
WITHDRAWN: Surgical Resection of a Presacral Solitary Fibrous Tumor with Extension to Iliac Vessels using Karakousis’s Abdominoinguinal Approach: Report of a Rare Case
Authors: Pachajoa Diana A. Pantoja , Huatuco René M. Palacios , Sambuelli Gabriela , Viscido Germán , Doniquian Alejandro M. , Mandojana Facundo
Published: March 2021

Background: The solitary fibrous tumor (SFT) is a rare tumor of mesenchymal origin, with a reported incidence of 2.8 cases per 100.000 tumors and with distinctive histopathological and immunohistochemical characteristics. It was initially described as a pleural lesion and subsequently, it was found in different organs and tissues. The abdominoinguinal incision described by Karakousis allows a radical reliable approach for abdominal-pelvic tumors in lower quadrants. We present the case of a patient with a presacral STF extending to iliac vessels, which required the Karakouis’s approach for its surgical resection.Case Presentation: Forty-seven-year-old man with pain in lumbosacral region radiating to left leg since 5 months. MRI and CT show evidence of a 10cm-retroperitoneal mass (presacral space) extending to left iliac vessels. The early diagnosis corresponded to a sarcomatous retroperitoneal tumor. It was decided to carry out the abdominal scan through the Karakousis’s approach for surgical resection with permanent neurovascular control. The immunohistochemistry and histopathological study revealed a CD-34 positive spindle-cell neoplasia, vimentin, Bcl-2, and β-catenin, compatible with a SFT. It was categorized as low risk for developing metastasis and death from disease, according to the new criteria for malignancy. At present, the patient is asymptomatic and disease-free at 17 months after surgery.Conclusion: Presacral SFT is a rare entity, with a scant incidence reported regarding this location and long-term treatment. Surgical resection is needed as the immediate treatment.
Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporosis
Authors: Wu Tianli , Yao Zhihao , Tao Gang , Lou Fangzhi , Tang Hui , Gao Yujin , Yang Xiaojuan , Xiao Jingang
Published: March 2021

Objective: Although it has been demonstrated that adipose-derived stem cells (ASCs) from osteoporosis mice (OP-ASCs) exhibit impaired osteogenic differentiation potential, the molecular mechanism has not yet been elucidated. We found that Fzd6 was decreased in OP-ASCs compared with ASCs. This study investigates the effects and underlying mechanisms of Fzd6 in the osteogenic potential of OP-ASCs. Methods: Fzd6 expression in ASCs and OP-ASCs was measured by PCR gene chip. Fzd6 overexpression and silencing lentiviruses were used to evaluate the role of Fzd6 in the osteogenic differentiation of OP-ASCs. Real-time PCR (qPCR) and western blotting (WB) was performed to detect the expression of Fzd6 and bone-related molecules, including runt-related transcription factor 2 (Runx2) and osteopontin (Opn). Alizarin red staining and Alkaline phosphatase (ALP) staining was performed following osteogenic induction. Microscopic CT (Micro-CT), hematoxylin and eosin staining (H&E) staining, and Masson staining were used to assess the role of Fzd6 in osteogenic differentiation of osteoporosis (OP) mice in vivo.Results: Expression of Fzd6 was decreased significantly in OP-ASCs. Fzd6 silencing down-regulated the osteogenic ability of OP-ASCs in vitro. Overexpression of Fzd6 rescued the impaired osteogenic capacity in OP-ASCs in vitro. We obtained similar results in vivo.Conclusions: Fzd6 plays an important role in regulating the osteogenic ability of OP-ASCs both in vivo and in vitro. Overexpression of Fzd6 associated with the Wnt signaling pathway promotes the osteogenic ability of OP-ASCs, which provides new insights for the prevention and treatment of OP.
N-acetylcysteine promotes osteogenic differentiation in periodontal ligament stem cells under cyclic mechanical stretch
Authors: Xi Xun , Li Zixuan , Zhao Yi , Liu Hong , Chen Shuai , Liu Dongxu
Published: March 2021

Background

Biomechanical forces are vital for the regulation of skeletal tissue. Mechanical stretch plays a vital role in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) during orthodontic treatment. Cyclic mechanical stretch may trigger the up-regulated production of reactive oxygen species (ROS). ROS has a critical effect on bone cell function and the pathophysiology of bone diseases. N-acetylcysteine (NAC), a ROS scavenger, possesses powerful antioxidant capacity. The aim of this study was to determine the role of ROS and NAC in PDLSCs during osteogenic differentiation under cyclic mechanical stretch. We further investigated that the therapeutic potential of NAC to improve the changes of the microstructure of alveolar bone during orthodontic tooth movement in rats by micro-CT system.
Methods

The expression of COL1 (collagen type I), RUNX2 (runt-related transcription factor 2) and OPN (osteopontin) by qRT-PCR and Western blot experiments, and alkaline phosphatase (ALP) staining as well as ALP activity tests were used to examine osteogenic differentiation tendency of PDLSCs subjected to cyclic mechanical stretch of 10% and 0.5Hz deformation induced by the Flexcell tension system. ROS production in PDLSCs were measured under cyclic mechanical stretch by Flow Cytometry. The levels of reduced glutathione (GSH), oxidized GSH (GSSG) and the GSH/GSSG ratio with or without NAC treatment were analyzed. And we evaluated the changes of the microstructure of alveolar bone during orthodontic tooth movement in rats employing micro-CT system.
Results

NAC treatment could promote the osteogenic differentiation of PDLSCs under cyclic mechanical stretch. Down-regulated ROS generation and the up-regulated level of GSH and the ratio of GSH/GSSG in PDLSCs treated with NAC were observed in response to cyclic mechanical stretch. NAC improved the microstructure of alveolar bone, including BV/TV (bone volume/total volume), Tb.Th (trabecular thickness), Tb.Sp (trabecular separation) and SMI (microstructure model index), during orthodontic tooth movement in rats.
Conclusion

These results revealed that NAC might be a potential therapeutic approach for the remodeling of the alveolar bone during orthodontic tooth movement.
Transcription shifts in gut bacteria shared between mothers and their infants: data from the NiPPeR Study
Authors: Vatanen Tommi , Sakwinska Olga , Wilson Brooke , Combremont Severine , Cutfield Wayne , Chan Shiao-Yng , Godfrey Keith , O’Sullivan Justin
Published: March 2021

The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We utilized community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads participating in the NiPPeR Study to characterize bacterial gene expression shifts following mother-to-infant transmission. Maternally derived bacterial strains adapted by large scale gene expression shifts following the transmission to the infant gut, with 12,564 activated and 14,844 deactivated gene families, including 1,007 transferases and 85 bacteriophage genes. The implicated genes were most numerous and the magnitude shifts greatest in Bacteroides spp. This study demonstrates environment-dependent, strain-specific shifts in gut bacteria function and underscores the importance of metatranscriptomic analysis in microbiome studies.
The characteristics of energy security in decentralised zones and autonomous objects of electrification
Authors: Lukutin В. V. , Kiushkina V. R.
Published: March 2021

The article aims to develop a set of objective criteria for assessing the state of energy security in decentralised remote regions of the north, Arctic zones and autonomous energy supply complexes. The authors assessed the potential of renewable energetics, which determines the effectiveness of decentralised energy complexes based on renewable energy sources, in improving the energy security of such entities. The indicators for assessing the energy security of research objects were developed on the basis of an analysis of the ratio of the most significant threats, as well as territorial and situational factors of the autonomous energy of the north and Arctic zones. A study of the security of the research objects allowed the development of a set of criteria for territorial segments and autonomous electrification objects, forming an objective assessment of the energy security of isolated hard-to-reach areas. An analysis of the possibilities of renewable energy sources in achieving certain positions (resource sufficiency, environmental acceptability, technological attainability and reliability) of the energy security of the considered level was conducted. Groups of properties and processes within the territorial framework of a decentralised region, separated by the directions of monitoring the energy security of local energy zones are proposed as objects of indicative analysis. The differentiation of the developed criteria by the levels of the energy zone and decentralised energy complex allowed consideration of all the specific features of these objects and cover the factors of mutual influence with accompanying systems in the formation of the state of energy security. When considering a possible option for the participation of renewable energy sources in the structural and resource provision of autonomous electricity supply, it was found that such diversification will affect both the improvement of some criteria of energy security of the considered level, as well as the deterioration of others.
Methodology for calculating the technological parameters of preventive deformation of the hardened parts of the "wall" type
Authors: Makaruk А. A. , Samoylenko О. V. , Ivanov Yu. N. , Chashchin N. S. , Minaev N. V.
Published: March 2021

The article aims to establish the effect of preventive deformation on the accuracy of aircraft parts made from the thermally hardened aluminium alloy 1933T2, after blasting hardening. Determination of the impact of preventive deformation was carried out by analysing structural parts of the "wall" type produced using various technological sequences. Sample 1 was produced using a standard manufacturing sequence: milling – blasting hardening – blasting correction. Sample 2 was produced as follows: milling – preventive deformation – hardening – blasting correction. The deformation of the samples was determined at checkpoints by deviations from flatness based on bending deflections. In sample 2, preventive deformation was performed on its ridges by a rolling device. The calculation of the technological parameters of the rolling device was conducted following the principle of superposition of individual operations, such as rolling and blasting hardening. The definition of the parameters of preventive deformation of sample 2 was based on the results ob tained for sample 1. It was established that, for both samples, the deviation from flatness after milling comprised 2.5 mm. The maximum deviation of sample 1 (without preventive deformation) after blasting hardening was 2.6 mm under a high degree of surface saturation. The maximum deviation of sample 2 (with preventive deformation) after blasting hardening did not exceed 0.4 mm, which corresponds to the acceptable deviation of such structural parts. Thus, the inclusion of the preventive deformation stage in the manufacturing process, with consideration of the deviations resulting from the milling stage, allows minimisation of deviations from the required form after blasting hardening. An analysis of the obtained re[1]sults confirmed that preventive deformation of structural parts reduces distortions after blasting hardening. Therefore, it is advisable to use the following manufacturing sequence: preventive deformation → hardening by a blasting method → correction by a blasting method.
NUTRITIONAL STUDIES AND QUANTITATIVE ANALYSIS OF CALOCYBE INDICA, MILKY MUSHROOM
Authors:   Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), Coimbatore, Tamil Nadu, India., Sankaranarayanan N.K. , Krishna Kumari S. ,   Department of Biochemistry, Kongunadu Arts and Science College (Autonomous), Coimbatore, Tamil Nadu, India.
Published: March 2021

Nutritional and Quantitative analysis of the milky mushroom (Calocybe indica) were carriedout. The nutritional analysis results showed the presence of Moisture,Crude fibre, ash and low content in fat value. Micro nutrients like Iron,Zinc,Copper Selenium and Manganese were tested along with Macro nutrients like Sodium,Potassium,Calcium,Phosphorus amd Magnesium were tested with mushroom dry powder. Quantitative analysis confirmed that both the mushrooms possess the presence of pharmacologically active compounds like phenols, flavonoids, saponins and tannins. Further subjection of these mushrooms for quantitative analysis showed the presence of protein 0.66 (T1), 0.61(T2),Free amino acids, 0.44(T1).0.35(T2),Total Phenols 0.55 (T1),0.80(T2),Tanin 0.14 (T1), 0.19( T2).Thus, the study suggests that mushroom varieties are nutrient rich and compounds that can be explored for their medicinal properties.
IN SILICO ANALYSIS OF DELTA 6 DESATURASE - A KEY ENZYME FOR OMEGA Â€“3/6Â€“ FATTY ACID PRODUCTION
Authors:   Student, Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Virudhnagr -626126, TamilNadu, India., Tharuni Boya , Sathish T. ,   Student, Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Virudhnagr -626126, TamilNadu, India., Nadana Raja Vadivu G. ,   Faculty, Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Virudhnagr -626126, TamilNadu, India., Vasumathi K. ,   Faculty, Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Virudhnagr -626126, TamilNadu, India.
Published: March 2021

Delta 6 desaturase is a key enzyme involved in the production of omega 3/6 fatty acids and it is the rate-limiting step. The study aims to characterize the delta 6 desaturase enzyme and to find the binding affinity of various ligand with the protein by docking. It is found that delta 6 desaturase enzyme sequence is very unique and has less similarity with the other desaturase protein. The structural analysis was performed by Ramachandran plot and SCOPe structure prediction. Modeller is used to determine the DOPE score of the selected enzyme. The lowest DOPE score protein is chosen to determine the binding affinity of ligand molecules. Three different ligands were selected and its interaction was determined by the PyRX - Autodock Vina. These studies will give a better idea of the interaction of various molecules, which help to deduce its function by further experimentation.
EFFECT OF METFORMIN ON WEIGHT REDUCTION AMONG DIABETIC AND NON-DIABETIC OBESE PATIENTS
Authors:   Department of Pharmacology and Toxicology, College of Pharmacy, University of Benghazi, Benghazi, Libya., F. Hussin Hanin , W. Alobidy Sanad ,   PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya., M. Bosafita Fatma ,   PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya., E. Mohamed Iman ,   Department of Pharmacology and Toxicology, College of Pharmacy, University of Benghazi, Benghazi, Libya.
Published: March 2021

Context: Metformin is the first line treatment in type II diabetes mellitus. In addition, it was used for weight reduction in both diabetic and non-diabetic obese patients. Aims: The aim of this study was to examine the efficacy of metformin in weight reduction among diabetic and non-diabetic obese patient in Benghazi, Libya. Settings and Design: a cross-sectional study Methods and Material: A hundred well-designed a cross-sectional survey was distributed from January to December 2020 and filled by diabetic and non-diabetic obese patients (66 and 34, respectively) in Benghazi city. Statistical analysis used: SPSS statistics soft wear (Version 21.0 SPSS Inc.: Chicago, IL, USA). Results: Results had shown that 66.7 % of diabetic obese patients were more than 50 years while 35.5 % of non- diabetic obese patients were 21-25 years. 1-5 kg was the weight reduction in both diabetic and non-diabetic obese patients (43.9 % and 38.2 %, respectively) Conclusions: According to this study, metformin is an eï¬€ective therapy to reduce weight in diabetic and non-diabetic obese patients. Further studies are needed with exact weight reduction.
PROCESS ORIENTED GUIDED INQUIRY LEARNING MODULE IN TEACHING EARTH SCIENCE: ITS ACCEPTABILITY
Authors:   Master of Arts in Teaching, Major in Science 2018., Teresa R. Beloy Maria
Published: March 2021

The aim of this study was to determine the acceptability of the developed Process Oriented Guided Inquiry Learning (POGIL) Module in teaching Earth Science as to grade 8 selected students of Pasig City Science High School and improve students success rate in learning. POGIL is an acronym for Process Oriented Guided Inquiry Learning. It uses guided inquiry â€“ a learning cycle of exploration, concept invention and application as basis for the teachers carefully designed instructional materials that students use to guide them to construct new knowledge. It is also a classroom and laboratory technique that seeks to simultaneously teach content and key process skills such as the ability to think analytically and work effectively as part of a collaborative team.
Assessment of temperature changes in carcasses in the early post-mortem period using the spectrum of a thermal imaging camera
Authors: LISTOS PIOTR , GRYZIŃSKA MAGDALENA , PANASIUK-FLAK KINGA , CIESIELKA MARZANNA , TERESIŃSKI GRZEGORZ
Published: March 2021

Precise determination of the time of death of a human being or animal is extremely important for investigations by law enforcement agencies. The aim of the study was to use a thermal imaging camera for imaging of the cooling of dog carcasses in controlled conditions, as a practical application of thermal imaging in veterinary forensics for the purpose of establishing the time of death of an animal, as well as to compare the usefulness of this method with that of the currently used Henssge nomogram. A thermographic technique exploiting infrared radiation was used in the study. The research material was 10 dog carcasses (5 female and 5 male) aged 6 to 16 years, with body weight from 23 to 36 kg. Thermal imaging of a carcass in combination with other methods, such as measurement of internal body temperature and analysis of post-mortem changes, enables reliable determination of the time of death of an animal, which is often of fundamental importance in veterinary forensic practice.
Specificerende il y a-clefts (er is-clefts)
Authors: Karssenberg Lena
Published: March 2021

In this paper, I investigate French il y a-clefts ('there is-clefts’) that are semantically specificational(e.g. ‘Are there vegetarians in your family?’ — Oui, il y a ma soeur qui estvégétarienne “Yes, there’s my sister who’s a vegetarian”). I show on the basis of a qualitativecorpus analysis in three different registers of French that this type of cleft is lessuniform than previously assumed in terms of its semantics, discourse functions and informationstructure properties.
Poverty Alleviation Policies in Malaysia and Nigeria: A review
Authors: Mohd Zain Zarina , Md Khalid Nor Suhaiza , Mat Nurudin Suzei , Onimisi Timothy
Published: March 2021

Poverty in Malaysia and Nigeria as well as most developing countries are alarmingly visible. The Gross Domestic Product (GDP) growth in recent years of Malaysia and Nigeria has not reflected in the poverty alleviation efforts from the governments of both countries. The need to review the past policies on poverty alleviation in these developing nations prompted this paper. Using secondary data sources, the poverty alleviation policy in Malaysia has made significant progress, while Nigeria is still struggling. Interestingly, after decades of poverty alleviation policies, Malaysia has been moving forward steadily although there are identifiable challenges to overcome while in Nigeria, the policies seems to have no progress due to lack of political will.
Keywords: Poverty Alleviation; Policy; Developing Countries
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i16.2694
Virtual Education Program to Support Providers Caring for People With Intellectual and Developmental Disabilities During the COVID-19 Pandemic: Rapid Development and Evaluation Study (Preprint)
Authors: Thakur Anupam , Pereira Cheryl , Hardy Jenny , Bobbette Nicole , Sockalingam Sanjeev , Lunsky Yona
Published: March 2021

BACKGROUND

People with intellectual and developmental disabilities are at increased health-related risk due to the COVID-19 pandemic. Virtual training programs that support providers in caring for the physical and mental health needs of this population, as well provide psychological support to the providers themselves, are needed during the pandemic.

OBJECTIVE

This paper describes the design, delivery, and evaluation of a virtual educational COVID-19–focused Extension for Community Healthcare Outcomes program to support providers during the COVID-19 pandemic in caring for the mental health of people with intellectual and developmental disabilities.

METHODS

A rapid design thinking approach was used to develop a 6-session program that incorporates mindfulness practice, a wellness check, COVID-19–related research and policy updates, a didactic presentation on a combination mental health and COVID-19 related topic, and a case-based discussion to encourage practical learning. We used the first 5 outcome levels of Moore’s evaluation framework—focusing on participation, satisfaction, learning, self-efficacy, and change in practice—which were rated (out of 5) by care providers from health and disability service sectors, as well as additional reflection measures about innovations to the program. Qualitative feedback from open-text responses from participants were analyzed using modified manifest content analysis.

RESULTS

A total of 104 care providers from health and disability service sectors participated in the program. High levels of engagement (81 participants per session on average) and satisfaction (overall satisfaction score: mean 4.31, SD 0.17) were observed. Self-efficacy (score improvement: 19.8%), support, and coping improved. Participants also rated the newly developed COVID-19 program and its innovative components highly. Open text feedback showed participants felt that the Extension for Community Healthcare Outcomes program expanded their knowledge and competency and created a sense of being part of a community of practice; provided value for the COVID-19 innovations; supported resource-sharing within and beyond program participants; and facilitated changes to participants’ approaches to client care in practice and increased participants’ confidence in supporting clients and families.

CONCLUSIONS

The Extension for Community Healthcare Outcomes program is an effective model for capacity-building programs with a shared-learning approach. Future iterations should include targeted evaluation of long-term outcomes such as staff burnout.