bluuebunny/crossref_metadata_2025 huggingface dataset:
An Evaluation of an Integrative Care Approach for End-Stage Renal Disease Patients
Authors: BIESEN WIM VAN , VANHOLDER RAYMOND C. , VEYS NIC , DHONDT ANNEMIEKE , LAMEIRE NORBERT H.
Published: May 2021

Studies analyzing the outcome of integrative care of end-stage renal disease (ESRD) patients, whereby patients are transferred from one renal replacement modality to another according to individual needs, are scant. In this study, we analyzed 417 files of 223 hemodialysis (HD) and 194 peritoneal dialysis (PD) patients starting renal replacement therapy between 1979 and 1996, to evaluate the effect of such an approach. Analysis was done for survival of patients on their first modality, for intention-to-treat survival (counting total time on renal replacement therapy, but with exclusion of time on transplantation), and for total survival. Log rank analysis was used and correction for risk factors was performed by Cox proportional hazards regression. Intention-to-treat survival and total survival were not different between PD and HD patients (log rank, P > 0.05). Technique success was higher in HD patients compared to PD patients (log rank, P = 0.01), with a success rate after 3 yr of 61 and 48%, respectively. Thirty-five patients were transferred from HD to PD and 32 from PD to HD. Transfer of PD patients to HD was accompanied by an increase in survival compared to those remaining on PD (log rank, P = 0.001), whereas, in contrast, transfer of patients from HD to PD was not (log rank, P = 0.17). Survival of patients remaining more than 48 mo on their initial modality was lower for PD patients (log rank, P < 0.01). A matched-pair analysis between patients who started on PD and who were transferred to HD later (by definition called integrative care patients), and patients who started and remained on HD, showed a survival advantage for the integrative care patients. These results indicate that patient outcome is not jeopardized by starting patients on PD, at least if patients are transferred in a timely manner to HD when PD-related problems arise.
Novel Methylcobalamin Nasal Spray versus Intramuscular Injection: A Randomized, Crossover Comparative Bioavailability Study
Authors: H Dave , V Agarwal , A Maseeh , KR Patel
Published: May 2021

Background/Objective: Methylcobalamin Nasal Spray (NasoB12®, Troikaa, India) has been recently developed to overcome the drawbacks of currently available therapeutic routes. This study was designed to compare pharmacokinetics, safety and tolerability of methylcobalamin nasal spray with intramuscular injection.
Multivariate Statistical Analysis of Archaeological Contexts: The case study of the Early La Tène Cemetery of Szentlőrinc, Hungary
Authors: Schneider Ágnes
Published: May 2021

This study would like to provide an open-source and reproducible workflow for multivariate statistical analysis of archaeological contexts, e.g. cemeteries. Further the study does not wish to republish the cemetery – it only discusses diagnostic artifact types which can be used for dating this specific cemetery.Also, the study shows that multivariate statistical analysis can be useful and that a bigger sample size (cemetery), higher number of artifacts and more associated artifact types in closed contexts can deliver better and more useful information for dating cemeteries or even building regional chronologies.
A Two-phase mixture model of Atmospheric Aerosols in the channel with an applied electric and magnetic field
Authors:   Department of Mathematics, Annamalai University, Chidambaram, 608 002, India, Meenapriya P , Maheswari K Uma , Ratchagar Nirmala P
Published: May 2021

Objectives: A mathematical model is constructed to investigate the concentration of aerosol mixture in the atmosphere. Aerosol is the significant constituent of the atmosphere, as it is playing a key role in environmental effects including air quality degradation, smoke-fog related accidents, acid rain formation, and visibility issues. The objective of this paper is to formulate the effects of aerosol mixture, and it is monitored through its concentration in the presence and absence of chemical reaction. The effects of concentration of aerosol mixture has to be reduced so as to enhance visibility. Methodology: A two-dimensional schematic geometry is considered which comprises the channel extended to infinity in the x-axis bounded by porous layers, also electric and magnetic field are applied transversely. A general exact solution of the dimensionless governing partial differential equations are obtained using perturbation technique with appropriate boundary conditions. Findings: Detailed results of velocity and concentration of the aerosol mixture were presented graphically. The graphical representation validated the accuracy of attained results with an encouraging level of agreement. As a measure to enhance the effects of air visibility, significant conclusions are specified using the obtained results. Keywords: atmospheric fluid; coagulation; concentration; porous layers; mixture theory
Numerical investigation of free convection through a horizontal open-ended axisymmetric cavity
Authors:   LP2M2E, Faculty of Sciences and Techniques, BP549, University Cadi Ayyad, Gueliz,Marrakech, 40000, Morocco, SAID Abdessadek AIT HAJ , ELFAGRICH Mahfoud , ABOUNACHIT Omar
Published: May 2021

Objectives: The purposes of this work are to investigate the free convective heat transfer in an axis-symmetric open-ended cavity heated from below and to propose useful correlations of Nusselt number. Methods: The governing equations that model the fluid flow and the temperature field are solved using a control volume-based finite differences method. Under steady state condition, the natural convective flow is considered to be laminar, incompressible and axisymmetric. The Boussinesq approximation with constant thermophysical properties is adopted. Numerical experimentations are performed to deduce the optimum sizes of the calculation domain and the mesh grid. Findings: the obtained results indicate that when Rayleigh number (Ra) and aspect ratio (A) are low the heat transfer is weak and mainly conductive. The increase of Ra and A enhances the convective heat transfer mode thereby the heat transfer is ameliorated. Unlike the Rayleigh Bénard convection, the transition from conduction to convection produces at critical value of Rayleigh number (Rac) that is variable dependent on A. Novelty: To the best of authors knowledge, the formula of (Rac) elaborated in this work for the studied cavity is the first attempt. As well, correlation of Nusselt numbers (Nu) for the cold upper plate in terms of Ra and A is performed. Comparisons between Nu at the lower plate given in previous work and Nusselt number at the upper plate is conducted. Keywords: free convection; circular plates; Nusselt number correlations; open ended cavity; critical Rayleigh number
The ‘Eudaimonic Experience’: A Scoping Review of the Concept in Digital Games Research
Authors: Daneels Rowan , Bowman Nicholas D. , Possler Daniel , Mekler Elisa D.
Published: May 2021

Digital games have evolved into a medium that moves beyond basic toys for distraction and pleasure towards platforms capable of and effective at instigating more serious, emotional, and intrapersonal experiences. Along with this evolution, games research has also started to consider more deeply affective and cognitive reactions that resemble the broad notion of eudaimonia, with work already being done in communication studies and media psychology as well as in human–computer interaction. These studies offer a large variety of concepts to describe such eudaimonic reactions—including eudaimonia, meaningfulness, appreciation, and self-transcendence—which are frequently used as synonyms as they represent aspects not captured by the traditional hedonic focus on enjoyment. However, these concepts are potentially confusing to work with as they might represent phenomenological distinct experiences. In this scoping review, we survey 82 publications to identify different concepts used in digital gaming research to represent eudaimonia and map out how these concepts relate to each other. The results of this scoping review revealed four broad conceptual patterns: (1) appreciation as an overarching (yet imprecise) eudaimonic outcome of playing digital games; (2) covariation among meaningful, emotionally moving/challenging, and self-reflective experiences; (3) the unique potential of digital games to afford eudaimonic social connectedness; and (4) other eudaimonia-related concepts (e.g., nostalgia, well-being, elevation). This review provides a conceptual map of the current research landscape on eudaimonic game entertainment experiences and outlines recommendations for future scholarship, including how a focus on digital games contributes to a more comprehensive understanding of eudaimonic media experiences broadly.
Challenges of the Transitional Justice in the Periphery: Lessons from Nueva Venecia Slaughter
Authors: Sarmiento Juan Pablo
Published: May 2021

Em 2005, o governo de Álvaro Uribe aprovou a Lei de Justiça e Paz (no 975/2005) e 40 leis adicionais para desmobilizar grupos armados fora da lei atuando na Colômbia, mas apenas as autodefensas, grupos violentos de direita, foram desmobilizadas. Essa lei, que visava reintegrar membros de grupos armados fora da lei à vida civil, estabeleceu “sanções alternativas” e conferiu à contrainsurgência das autodefensas uma natureza política. Desafios da justiça transicional na periferia: Lições do massacre de Nueva Venecia argumenta que, apesar do desenvolvimento de instrumentos legais relacionados aos direitos das vítimas e à justiça transicional, o Estado colombiano não conseguiu reparar e restaurar a dignidade da população estudada.
Pacificação, diminuição da belicosidade e desenvolvimento humano em um mundo organizado pela tradição militar e armamentista
Authors: Rezende Maria José De
Published: May 2021

Esta pesquisa tem como fonte os Relatórios do Desenvolvimento Humano (RDHs/PNUD/ONU). Objetiva-se compreender o significado político da tentativa, dos produtores de tais materiais, de gerar agendas públicas que envolvam os Estados, os governos e os organismos internacionais no processo de dissuasão das ações e dos procedimentos que têm levado a muitos conflitos bélicos e guerras civis e entre países. Os reflexos perversos das políticas belicosas são sentidos na economia, na infraestrutura e nos serviços sociais. As expectativas de avanços nos Índices de Desenvolvimento Humano (IDH) são aniquiladas pelos conflitos bélicos e violência em geral.
Legal Sensibilities and Implicit Filtering in the Administration of Second Degree Murder on Criminal Persecution
Authors: Lima Michel Lobo Toledo
Published: May 2021

Sentidos de justiça e filtragem implícita na administração de homicídios dolosos na persecução penal apresenta dados e análises preliminares de etnografia que compõe parte da minha pesquisa de pós-doutorado em andamento. Descrevo e analiso as lógicas que orientam a administração institucional da categoria “homicídio doloso” ao longo da persecução penal. A hipótese é que tal crime não tem um caráter imutável nem puramente legal, dependendo assim da valoração policial e judicial perante cada caso, motivando como estes devem ser administrados institucionalmente. O fim é expor algumas contradições da cultura jurídica brasileira, explorando os usos das sensibilidades jurídicas na análise de fluxo para tal crime.
De ‘cartão-postal’ a ‘área de risco’: A (re)produção de Copacabana em meio a novas disputas e territorialidades
Authors: Polycarpo Clara
Published: May 2021

Este texto discute a (re)produção de Copacabana, reconhecida no imaginário carioca como “cartão-postal” do Rio de Janeiro, em um contexto de violência urbana e informalidade capaz de atualizar as disputas por territórios e fronteiras da cidade. A partir da análise de reuniões do Conselho Comunitário de Segurança de Copacabana e Leme (CCSCL) e dos discursos e representações de camadas médias moradoras desse bairro a respeito do atual conflito urbano, é possível perceber que os termos de distinção de Copacabana são postos em xeque por meio de diferentes concepções de segurança e de novas formas de se fazer políticas perpassadas pelo medo da favelização.
Review of the article “Complications after radical cystoprostatectomy with various variants of the heterotopic ureteroneocystostomy”
Authors: Darenkov S. P.
Published: May 2021

На сегодняшний день существует не так много тем в урологии, которые порождают среди отечественных и иностранных специалистов столь же много оживленных споров и дискуссий, как вопрос выбора метода отведения мочи после цистэктомии.
Kaposi's sarcoma of the penis in HIV-negative patients: case series
Authors: Ognerubov N. A. , Blokhin A. V. , Gumareva G. E.
Published: May 2021

Kaposi's sarcoma is a malignant vascular tumor associated with human herpesvirus-8 (HHV-8). The disease primarily affects the skin, mucous membranes, lymph nodes, and even internal organs in late stages. Kaposi's sarcoma of the penis is usually found in patients infected with human immunodeficiency virus (HIV) and is exceedingly rare in HIV-negative patients.

In this article, we report 2 cases of Kaposi's sarcoma in a 42-year-old and 55-year-old patients. Both patients denied any homosexual relationships. Their tumors were represented by 5-mm nodules located close to the external urethral orifice. Both patients have undergone tumor excision. Histological and immunohistochemical examinations demonstrated Kaposi's sarcoma. The 55-year-old-patient had positive nuclear staining with anti-HHV-8 antibodies in the tumor cells, although no anti-HIV antibodies were found in his serum. The 42-year-old patient had a clinically significant increase in the level of human papillomavirus 51 (HPV-51) DNA detected using polymerase chain reaction in his urethral swab sample (3.2 х 10 5 Lg). Both patients were alive after 36 and 34 months, respectively, without signs of disease progression.
Urinary incontinence after radical prostatectomy: prognostic factors
Authors: Aboyan I. A. , Orlov Yu. N. , Shevchenko A. N. , Pakus S. M. , Hasigov A. V.
Published: May 2021

Prostate cancer is the most common urological malignancy in men. Radical prostatectomy (RPE) ensures high rates of relapse-free survival. Urinary incontinence is a frequent complication after RPE that significantly reduces the quality of life and leads to social maladaptation of the patient. Advances in pelvic anatomy, optimization of surgical techniques, and implementation of laparoscopic and robot-assisted surgery have improved functional results of RPE. However, the increasing incidence of prostate cancer leads to an increase in the number of patients after RPE and, accordingly, patients with urinary incontinence. Therefore, issues related to etiology, pathogenesis, and prevention of urinary incontinence after RPE remain highly relevant. Numerous publications suggest that etiology of urinary incontinence after RPE is multifactorial. The purpose of this literature review is to provide an overview of studies on urinary incontinence after RPE. We analyze the role of preoperative and intraoperative parameters as possible risk factors for urinary incontinence after RPE.
Nephrectomy and thrombectomy in renal cell carcinoma patients with extensive tumor venous thrombosis: how to minimize surgical risks?
Authors: Matveev V. B. , Stilidi I. S. , Volkova M. I. , Vashakmadze N. L. , Klimov A. V. , Begaliev A. K. , Feoktistov P. I. , Kuznetsov K. P. , Davydov M. I.
Published: May 2021

Objective: to evaluate the outcomes of thrombectomy performed using different surgical techniques in renal cell carcinoma (RCC) patients with extensive tumor venous thrombosis.

Materials and methods. This study included 345 RCC patients with extensive tumor venous thrombosis who underwent surgical treatment.

The median age was 57 years (range: 16—79 years); the male-to-female ratio was 1:1.9. Two hundred and sixty patients (75.4 %) had their tumor thrombus originating from the right renal vein, 85 patients (24.6 %) — from the left renal vein. In 169 patients (49.0 %), the thrombus spread to the retrohepatic inferior vena cava (IVC), while in 176 patients (51.0 %), it spread above the diaphragm (to the intrapericardial IVC in 59 patients (17.1 %) and to the right heart cameras in 117 patients (33.9 %)). Regional metastases were found in 90 individuals (26.1 %), while distant metastases were observed in 124 patients (35.9 %). All patients underwent surgical treatment (radical in 251 patients (72.8 %) and cytoreductive — in 94patients (27.2 %)); the technique of vascular control and circulatory support was chosen individually. In 97 patients (28.1 %), the control over the cranial thrombus boarder did not require opening of the chest cavity; eleven patients (3.2 %) were operated on with cardiopulmonary bypass.

Results. The median surgery time was 215 minutes; the median blood loss was 4500 mL. Intraoperative complications were registered in 209 patients (60.6 %) and postoperative complications were observed in 118 patients (35.1 %) (including those of grade I—II in 43 individuals (12.8 %) and grade III—V in 75 individual (22.3 %)). The in-hospital mortality rate was 10.7 % (37/345). At a median follow-up of 32.3 months, overall and diseasespecific survival rates among all patients were 51.9 % and 68.3 %, respectively; relapse-free survival rate in 226patients who have undergone radical surgeries and discharged from the hospital was 61.5 %; progression-free survival rate in 82 patients who have undergone cytoreductive surgery was 33.0 %. The method ofIVC control and circulatory support had no effect on both short-term and long-term treatment outcomes (p >0.05 for both).

Conclusion. The use of minimally invasive techniques of vascular control and avoidance of cardiopulmonary bypass in carefully selected RCC patients with extensive tumor venous thrombosis do not worsen the outcomes of nephrectomy and thrombectomy.
PRIAPOS trial: new conception of pathogenesis of post-brahytherapy erectile dysfunction
Authors: Novikov R. V. , Ponomareva O. I. , Novikov S. N.
Published: May 2021

Objective: to study the anatomical-topographical relationship between the prostate gland (PG) and the vascular structures responsible for erection, to justify the new concept of erectile dysfunction pathogenesis after brachytherapy of prostate cancer (PCa).

Materials and methods. The study included 66 patients with verified or suspected PCa. All patients performed magnetic resonance imaging 1.5 T in accordance with the established protocol (hybrid method of visualization of internal pudendal arteries (IPA)). 16 patients simultaneously performed computed tomography on a topometric tomography. The resulting images were analyzed using the Eclipse 4.0 (Varian Medical System, USA) system, which provides 3D models of PG, pelvic bones and critical structures of interest: IPA, cavernous crura and penile bulb.

Results. The average volume of PG was 44.9 ± 18.7 (14.4—98.0) cm3. The width of penile bulb was 1.83 ± 0.38 (1.1—2.93) cm. According to the implantation technique of in brachytherapy, the damage to penile bulb can be observed in less than a fifth of patients — 18.5 % of cases.

Analysis of the 3D models showed that the overlay of the distal third of the IPA on the predominantly anterior and, in part, lateral aspects of the PG was noted in 58 (87.9 %) of 66 observations. The average value of PG in a group with no interference was 25.7 ± 3.9 (18.2—29.9) cm3, with its presence — 47.6 ± 18.4 (14.4—98.0) cm3. The average length of the IPA, coinciding with the projection of the PG on the right and left is virtually no different (p >0.05) and is about 2.5 cm, and the maximum remote point of this combination lies in relation to the outer contour of the gland within 1 cm. The correlation analysis showed a strong direct correlation between the volume of PG with all the parameters of mutual spatial anatomy of the prostate and IPA (R = 0.63—0.71; p <0.0001).

Conclusion. The anatomical-topographical relationship between PG and critical structures, among which the IPA plays a special role, points to the likely predominantly traumatic genesis of erectile dysfunction after PCa brachytherapy, as well as a number of other invasive procedures performed by perineal access (saturation biopsy).
Clinical significance of mutations in DNA repair genes in patients with metastatic prostate cancer
Authors: Mailyan O. A. , Kalpinskiy A. S. , Reshetov I. V. , Nyushko K. M. , Alekseev B. Ya. , Kokin S. P. , Stakanov V. A. , Golovashchenko M. P.
Published: May 2021

Prostate cancer (PCa) is one of the most common malignant tumor in men. Significant advances have been made in the early detection and treatment of localized PCa, but metastatic castration-resistant PCa (mCRPC) remains one of the most challenging problems to treat in oncology. To improve treatment outcomes for patients at this stage of the disease, it is necessary to develop personalized therapy options based on the definition of biological predictors. In mCRPC, mutations in DNA repair genes are detected in ~23 % of patients with mCRPC. Detection of these mutations in patients with PCa has important clinical relevance. PCa with mutations in DNA repair genes may be sensitive to poly(ADP-ribose)-polymerase (PARP) inhibitors. Several studies II and III phase have demonstrated the effectiveness of PARP inhibitors with a high objective response rate in the treatment of mCRPC in patients with mutations in the DNA repair genes, which is definitely a more personalized approach to treatment. Identification of hereditary mutations in DNA repair genes is an important prognostic factor for the proband's relatives (for both men and women), which can later be used for genetic counseling of patients and the application of strategies to reduce the risk of malignant diseases.
INNOVATIONS AND INTERNATIONALISATION IN THE CONTEXT OF THE RUSSIAN ECONOMY
Authors: Semina K. S.
Published: May 2021

This article examines the state of Russian exports and innovations. The author analyses government regulation, as well as the structure and dynamics of international and innovative activities of Russian manufacturers. In addition, the position of Russia in international studies and ratings has been studied.
THE RELATIONSHIP BETWEEN THE PERSONAL CHARACTERISTICS OF THE CEO AS "RISKINESS" AND THE INNOVATIVE ACTIVITY OF THE COMPANY
Authors: Belyaeva K. G. , Arsenova E. V.
Published: May 2021

An important role in the functioning of the economy and in the analysis of the competitiveness of companies is played by the top management echelon, represented by charismatic CEOs, who often determine the direction of company development, considering the specifics of everyday life and general organizational processes. There is a transformation of the stages of value formation, the zones of profitability are shifting, new players are emerging – all this creates a completely different ratio of shares in the industries, greatly accelerating the generation and implementation of new ideas and developments. Companies must respond to new technologies in a much riskier way and understand that the time stage of their implementation should be reduced. The article analyzes the position of the personal characteristics of CEOs, in particular, such qualities as "riskiness", and their impact on the innovative activities of companies. The object of studying this relationship is the world-class CEO as an example of successful implementation of innovation through the ability to take risks in a timely manner.
Comparative Analysis of Space Maintenance Using Transpalatal Arch and Nance Button
Authors: Martín-Vacas Andrea , Caleya Antonia M. , Gallardo Nuria E.
Published: May 2021

The aim of this manuscript analyses the efficacy of Transpalatal Arch (TPA) and Nance Button (NB) in maintaining space after the premature loss of upper primary molars. Study design: 54 subjects who needed space maintenance in the upper arch (23 in the TPA group and 31 in the NB group) and had radiographic follow-up until the appliance removal were enrolled in the study. The space loss was obtained from measurements carried out in initial and final radiographs. Type of dental loss and changes in molar relationship were also recorded. Results: The mean of space loss in the TPA group was 1.336mm, while in the NB group was 0.695mm, with no statistically significant differences between the total space loss neither the type of dental loss within the NB or TPA group (p >0.05). Conclusions: The loss of space in the unilateral second primary molar is higher in the TPA group than in the NB group, with significant statistically differences (p<0.05). It is concluded that the loss of the leeway space using a TPA as a space maintainer is greater than using a NB.
Treatment Outcomes of Pulpectomy in Primary Maxillary Incisors Filled with ZOE and Metapex: A Two-year Retrospective Study
Authors: Ou-Yang Li-Wei , Chang Pei-Ching , Chuang Li-Chuan , Yu Hsiu-Ting , Tsai Aileen I
Published: May 2021

Objectives: To address a literature gap by evaluating, in a larger set of samples, the clinical and radiographic outcomes of pulpectomy in primary maxillary incisors using ZOE and calcium hydroxide/iodoform paste. To also identify the predisposing factors for treatment outcomes. Study design: Medical charts of 124 patients (aged 16 to 60 months) and radiographs of their incisors (309 incisors) were reviewed (128 with ZOE and 181 with Metapex). All incisors were restored with composite resin crowns. Results: The radiographic success rates for ZOE and Metapex were: 85.9% and 82.9% at the 12-month recall, and 69.2% and 64% at the 24-month recall, with no statistically significant difference between the two groups. Clinical failures occurred more frequently in the Metapex group (P = 0.006), as clinical signs of pain and soft tissue pathosis were found in 6.2% of the Metapex cases at 24 months but none in the ZOE group. Significant predisposing factors for radiographic success were type of tooth, degree of obturation at recalls, and preoperative root resorption. Conclusions. The radiographic success rates are comparable between the ZOE and Metapex groups. Clinical pathological manifestations such as pain and soft tissue pathosis are seen in the Metapex group at recalls, but none in the ZOE group. Predisposing factors such as type of incisor, preoperative root resorption, and extent of filling at recalls are associated with the radiographic success rate.
Tooth Discoloration Induced by Different Calcium Silicate–Based Cements: A Two-Year Spectrophotometric and Photographic Evaluation in Vitro
Authors: Nagas Emre , Ertan Atila , Eymirli Ayhan , Uyanik Ozgur , Cehreli Zafer C
Published: May 2021

Objective: Calcium silicate-based cements (CSCs) may lead to coronal staining in young permanent teeth over the time. The purpose of this study was to evaluate and compare the long-term tooth discoloration induced by different CSCs. Study Design: Ninety freshly-extracted human molars were assigned randomly into 6 groups (n=15/group) according to the CSC used as a pulpotomy material: ProRoot MTA, MTA Angelus, NeoMTA, EndoSequence Putty, Biodentine and Negative control (No cement). The color was assessed at baseline, and thereafter at 3, 6, 12 and 24 months by using both a spectrophotometer and digital images taken with and without a cross-polarizing filter. The time-dependent changes in color (ΔE) were compared within and among groups using Analysis of Variance. Results: Angelus MTA and ProRooT MTA showed severe coronal discoloration (p>0.05) starting at 3 months. ΔE values of NeoMTA, EndoSequence Bioceramic Putty and Biodentine were below the perceptibility threshold, with Biodentine showing greater ΔE values than NeoMTA and EndoSequence Putty in the absence of statistical significance (p>0.05). Conclusions: Discoloration elicited by CSCs may develop soon after placement, and continue to increase for up to two years. Angelus MTA and ProRooT MTA cannot be recommended for vital pulp therapies in the esthetic zone of young individuals.
A clinical case of a successful step-by-step treatment of a patient with a dissecting aneurysm of the ascending aorta involving the trunk of the left coronary artery
Authors: Bocharov Aleksandr V. , Popov Leonid V.
Published: May 2021

Background: The presented clinical case shows a version of successful step-by-step medical care for a patient with a dissecting aneurysm of the ascending aorta involving the trunk of the left coronary artery in a vascular center without a cardiac surgical support. Clinical case description: The patient was admitted to the Kostroma Regional Vascular Center with the symptoms of Acute Coronary Syndrome. During the examination in the clinic, the diagnosis of acute coronary syndrome with ST segment elevation was confirmed, and a dissecting aneurysm of the ascending aorta was also revealed. According to emergency coronary angiography, the dissection of the left coronary artery trunk was visualized, and the left coronary artery trunk was successfully stented with a bare metal stent. Later, the patient was transferred to a federal center, where aortic prosthetic reconstruction was performed. Conclusion: In patients with a dissecting thoracic aortic aneurysm involving the trunk of the left coronary artery and acute myocardial damage, who are admitted to a vascular center without a cardiac surgery support, the following step-by-step treatment strategy is likely to be effective: stenting the trunk of the left coronary artery with a bare metal stent and a further transfer to a center of cardiac surgery for a surgical treatment.
Major predictive risk factors for а cytokine storm in COVID-19 patients (a retrospective clinical trials)
Authors: Anisenkova Anna Yu. , Apalko Svetlana V. , Asaulenko Zakhar P. , Bogdanov Alexander N. , Vologzhanin Dmitry A. , Garbuzov Evgenii Y. , Glotov Oleg S. , Kamilova Tatyana A. , Klitsenko Olga A. , Minina Evdokiia M. , Mosenko Sergei V. , Khobotnikov Dmitry N. , Sсherbak Sergey G.
Published: May 2021

Background: According to WHO, as of March 31, 2021, 127 877 462 confirmed cases of the new COVID-19 coronavirus infection were registered in the world, including 2 796 561 deaths (WHO Coronavirus Disease). COVID-19 is characterized by a wide range of clinical manifestations, from asymptomatic to a rapid progression to severe and extremely severe. Predictive biomarkers for the early detection of high-risk individuals have become a matter of great medical urgency. Aims: Search for the predictors of a cytokine storm in patients with COVID-19 infection and creation of a risk scale of this complication for practical applications. Methods: The study included 458 patients with confirmed COVID-19 infection with signs of viral lung lesions according to the computer tomography data. The patients were divided into 2 groups: those with a stable course of moderate severity (100 patients) and those with progressive moderate, severe and extremely severe course (358 patients). Results: It has been established that the main risk factors for the development of a cytokine storm in COVID-19 patients are the following: interleukin-6 concentration 23 pg/ ml, dynamics of the index on the NEWS scale 0, ferritin concentration 485 ng/ml, D-dimer concentration 2.1, C-reactive protein concentration 50 mg/l, number of lymphocytes in the blood 0.72109/l, age 40 years. The cytokine storm incidence correlates with an increase in the number of risk factors. For the practical testing the scale was applied in 3 groups. In patients of the first group (01 factor) almost no cytokine storm risk was found, in the second group (2 -3 factors) the probability of the storm was 55% (increase by 35.5 times), in the third group (4 risk factors) it reached 96% (increase by 718 times). Conclusion: The diagnostic and monitoring criteria of a cytokine storm have been established in patients with COVID-19 infection. The developed prognostic scale allows identification of patients at high risk of developing a cytokine storm so that early anti-inflammatory therapy could be started.
The immune response to the novel coronavirus infection
Authors: Fedorov Vyacheslav S. , Ivanova Olga N. , Karpenko Inna L. , Ivanov Alexander V.
Published: May 2021

This review summarizes the current knowledge on the humoral and T-cell immunity to the novel coronavirus infection. A special attention is paid to the viral proteins that induce production of antibodies, different types of immunoglobulins and their role in the protection against the virus as well as to the duration of the humoral immune response. In addition, a concise analysis of the T-cell immunity status during COVID-19 and its input into the antiviral defense is presented. The collected data demonstrating preservation of both the humoral and T-cell immunity are urgently needed in the medical professionals' community for evidence-based decisions on the immunity monitoring, estimation of (re)vaccination time, as well as for knowing the factors that should be considered while choosing the most effective vaccine. Finally, several directions for the future research are pointed out
Ipsilateral block or can a single ECGbe used for the diagnosis?
Authors: Konev Aleksey V. , Simonenko Evgeniya V. , Khimiy Orysya V. , Korolev Sergey V. , Dundua David P.
Published: May 2021

Background: Pre-excitation syndrome (premature excitation of the ventricles) is a congenital anomaly in the structure of the cardiac conduction system and consists in the presence of an additional atrioventricular connection. The possibility to assume the presence of pre-excitation syndrome accompanied by tachycardia based on an electrocardiogram provides a clue to the correct diagnosis and subsequent treatment of the patient. Clinical case description: A clinical case of a 56-year-old patient is presented, who was admitted to the FRCC of the FMBA of Russia in January, 2021 with paroxysms of previously undiagnosed tachycardia. During Holter monitoring, an episode of heart palpitations was recorded. When analyzing an ECG fragment, it was possible, by calculating the tachycardia cycle length, to suspect the presence of a latent ventricular pre-excitation syndrome, which was accompanied by the development of orthodromic atrioventricular reciprocal tachycardia with a bundle branch block on the side of the additional atrioventricular connection (ipsilateral block). The patient underwent endocardial electrophysiological examination to confirm the presence of the bundle, followed by the catheter treatment of the atrioventricular connection. A good postoperative clinical result was obtained. Conclusion: It is important to be able to make a differential diagnosis between the presence of a latent pre-excitation syndrome with the development of orthodromic atrioventricular reciprocal tachycardia with the bundle branch block on the side of the extra atrioventricular junction (ipsilateral block) and other supraventricular tachycardias with an aberration along one of the bundle branches, in order to determine the tactics of the patient management and to control the effectiveness of the treatment.
Relocation of Seismicity in the Guadalentín Tectonic Valley, Eastern Betics Shear Zone (Southeast Iberia)
Authors: Sánchez-Roldán José Luis , Martínez-Díaz José J. , Cantavella Juan V. , Álvarez-Gómez José A. , Morales José
Published: May 2021

The eastern Betics shear zone comprises one of the most seismically active areas in Iberia, due to the presence of large active faults loaded by the oblique convergence between Eurasia and Africa plates. We focus our study on the sector of the eastern Betic Cordillera affected by the Alhama de Murcia fault (AMF) and other nearby faults that are the source of large paleoseismic events and some damaging historical earthquakes. This study aims to give more accurate locations to the hypocenters in the region around these faults, using a model that accounts for lateral variations of P-wave velocity. This task was accomplished, developing a new 3D velocity crustal model of the region, by combining recent regional and local geological and geophysical data, such as geological mapping, gravimetry, seismic-wave tomography, and seismic exploration surveys. Afterward, as a preliminary test of performance, we compared the hypocenters obtained with this model against the ones computed with other 1D velocity models, using NonLinLoc with a seismic dataset of the highest possible quality (i.e., filtered by a minimum magnitude) in this area within the period January 2015–December 2018. Then, for comparing the reliability of the new 3D local model against a larger 3D regional model, we carried out a final relocation with all the earthquakes of the Spanish Seismic Catalog in the study area for the period April 2011–October 2019. New locations obtained with the local model, which show better clustering near active structures and lower epicentral uncertainty in comparison with the regional model, allow us to observe possible genetic relation between seismicity and specific faults after the inversion, in particular, the AMF.
Rupture Models of Recent Mw>7 Thrust Earthquakes in the Guerrero–Oaxaca Region of the Mexico Subduction Zone Using Teleseismic Body Waves
Authors: Mendoza Carlos , Martínez-López M. Rosario
Published: May 2021

We invert the teleseismic broadband (1–60 s period) ground-displacement body waveforms recorded for the 1995 Mw 7.3 Copala, the 1996 Mw 7.1 Oaxaca, the 2012 Mw 7.5 Ometepec, and the 2018 Mw 7.2 Pinotepa Nacional thrust earthquakes in the Guerrero–Oaxaca portion of the Mexico subduction zone to derive the best-fit rupture models using a sampling procedure in which input fault parameters are selected from a prescribed range of values. More than 400 independent inversions are performed for each event using random combinations of strike, rake, dip, and hypocenter depth. Waveform fits are observed to be relatively insensitive to variations in strike, rake, and focal depth but show a distinct dependence on fault dip. The lowest residuals are limited to a dip interval of about ±3°, indicating that a relatively precise estimate of the fault dip is necessary for the optimal derivation of slip models using teleseismic body waves. The best-fit teleseismic source models obtained for the four events show varying degrees of spatial detail, with the 2012 and 2018 earthquakes exhibiting more separated slip along the fault than has been observed in rupture models derived using frequency bands covering longer periods. Areas of high-interplate slip for the four events do not overlap, suggesting an adjoining pattern of asperity zones that is consistent with prior observations in northwest Mexico and in the New Britain region of the South Pacific. Additional investigation of this type of asperity interaction for recurrent events would be beneficial, given the implications for estimating the size and location of future large subduction earthquakes.
A Fast GUI-Based Tool for Group-Velocity Analysis of Surface Waves
Authors: Ryberg Trond , Haberland Christian , Green Robert G. , Sens-Schönfelder Christoph
Published: May 2021

We present an interactive graphical tool for extraction of group-velocity dispersion curves of seismic traces for rapid manual picking of large amounts of data: a task commonly encountered in ambient-noise tomography. The program can be used for group-velocity analysis of surface waves from earthquakes and controlled source data as well as of Green’s functions from cross-correlated ambient-noise data. The presented tool is especially suited to datasets in which automatic picking algorithms fail and so dispersion analysis is only possible by visual inspection. Such situations can occur in highly heterogeneous regions with complex surface-wave dispersion or where surface-wave arrivals are poorly emerged (as can often be the case with ambient-noise-derived Green’s functions from temporary seismic deployments). In these datasets, the poor signal-to-noise ratio, spectral holes, or limited bandwidth may therefore mean that manual analysis is the only choice. However, without an efficient workflow the feasibility of this can be seriously constrained by the analysis time for the potentially vast number of traces to be analyzed. We tackled this problem by implementing well-known techniques of dispersion curve analysis (traditional frequency–time analysis) in a fast and interactive graphical environment. It is specifically developed for high user processing speed, prioritizing fast computation, and high display responsiveness. This solution retains the benefits of manual dispersion picking for complex datasets, while maintaining good user processing efficiency. An experienced analyst can measure upward of 200 traces per hour. xdcpick stands for an X-window-based picking of dispersion curves.
Rezene ve Defne Uçucu Yağ Karışımlarının Kimyasal Bileşenlerinin ve Pestalotiopsis funerea’ya Karşı Antifungal Etkinliklerinin Belirlenmesi
Authors: KARA Merve , TÜRKMEN Musa , SOYLU Soner
Published: May 2021

Fungal hastalık etmeni Pestalotiopsis funerea, kozalaklı çam ağaçlarında sürgün uç yanıklığı olarak bilinen hastalığa neden olur. Bu çalışmada, farklı oranlarda harmanlanmış rezene (Foeniculum vulgare Mill.) ve defne (Laurus nobilis L.) uçucu yağ karışımlarının kimyasal bileşimleri ve P. funerea’ya karşı antifungal etkileri in vitro koşullarda araştırılmıştır. Uçucu yağların kimyasal bileşimleri, GC-MS analizi kullanarak belirlenmiştir. Uçucu yağların buhar fazındaki farklı konsantrasyonların misel gelişimi ve konidi çimlenmesinin engellemesi üzerine antifungal etkileri in vitro koşullarda belirlenmiştir. Uçucu yağ karışımlarının en etkili olduğu konsantrasyonlarda fungus hifi ve konidi morfolojisinde neden olduğu etkileri ışık mikroskobu altında incelenmiştir. GC-MS ile yapılan kimyasal analizler sonucunda eucalyptol (%52.88) ve trans-anethole (%81.55)’ün defne ve rezene uçucu yağlarının ana bileşenleri olduğu belirlenmiştir. Tek başlarına kullanıldığında rezene ve defne uçucu yağları P. funerea’nın misel gelişimini 20.0 ve 25.0 µl petri-1 konsantrasyonlarında tamamen engellemiştir. Rezene/defne uçucu yağlarının harmanlanması ile misel gelişimi ve konidi çimlenmesinin engellenmesinde sinerjik antifungal etki görülmüştür. Rezene:defne uçucu yağların 3:1 oranında harmanlanması antifungal etkinliği önemli düzeyde artırmış olup, nispeten düşük konsantrasyonda (10 µl petri-1) daha yüksek düzeyde antifungal etkinlik göstermiştir. Işık mikroskobu ile yapılan gözlemlerde uçucu yağ harmanlarının en etkili konsantrasyonuna maruz kalan hifler ve konidilerde, sitoplazmik pıhtılaşma, vakuolleşme ve protoplazmik içeriğin hücre dışına akıntısı şeklinde gerçekleşen önemli yapısal deformasyonları gözlenmiştir. Sonuçlar, sinerjik antifungal etki gösteren rezene ve defne uçucu yağ karışımının bitki fungal hastalık etmenlerle mücadelede etkili bir biyofungisit olarak kullanılabileceğini göstermiştir.
Abdominal intussusception associated with coeliac disease: case report and literature review
Authors: Hameed Rashid , Irrum Noshine , Arachchige Subodhini P. , Tan Edwin , Tobin Jacinta
Published: May 2021

In genetically susceptible individuals, gluten ingestion triggers and immune infiltration and bowel damage in the classical pattern of coeliac disease, with variable symptoms. Intussusception is a condition where one segment of intestine ‘telescopes’ inside of another portion of intestine, which may cause symptoms of abdominal pain due to obstruction. Intussusception has been associated with coeliac disease. We report a 4-year-old girl presented with recurrent abdominal pain of variable severity and found to have intussusception on two occasions, which on both occasions reduced spontaneously during ultrasound examinations. She was later diagnosed with coeliac disease. This case highlights the importance of considering coeliac screening in patients with a history of recurrent abdominal pain and intussusception.
Standing of Mortgage Rights on Cultivation Rights That Have Been Determined as Deflanded Land in Solok District
Authors: Putera Alvin Rachman , Yuslim Yuslim , Andora Hengki
Published: May 2021

Cultivation Right are rights to exploit land which is directly controlled by the state for agricultural, fishery or livestock companies for a period of time. One of the reasons for the removal of the cultivation right was because it was neglected. cultivation rights is one of the land rights that can be used as collateral for debt and encumbered with mortgage rights. The write-off of the mortgage rights because the write-off of land rights that are encumbered with a security right does not cause the guaranteed debt to be written off. In practice, the abolition of the cultivation right which is being subject to mortgage rights due to a decision to determine abandoned land creates confusion regarding the repayment of debts between the debtor (PT. Karatau Limo Sajati) and the creditor (PT. Bank Rakyat Indonesia Tbk.) And the difficulty of utilizing the former cultivation right object which is has been designated as abandoned land. The problems in this research are 1) how is the process of controlling cultivation right as an object of abandoned land in Solok Regency ? 2) what is the position of the mortgage rights above the cutivation rights which has been designated as abandoned land in Solok Regency ? 3) how is the utilization of the ex-cultivation rights land on which a mortgage has been imposed after it has been designated as abandoned land in Solok Regency ? The approach method used is juridical empirical, the nature of the research is descriptive analytical, the research data used is in the form of primary data, namely through interviews with sources and literature study to obtain secondary data. The data is processed systematically and analytically. The results showed that 1) the control process of PT. Karatau Limo Sajati as an abandoned land object which is carried out by means of inventory, identification and research, warnings, the proposal to determine abandoned land and the determination of abandoned land can actually be canceled through a lawsuit to the PTUN based on the weaknesses in the warning process. 2) the position of the mortgage over the cultivation rights which has been designated as abandoned land has been abolished, but the abolition of the mortgage because the termination of the land title does not cause the guaranteed debt to be canceled and subsequently the debtor's debt repayment is regulated in Articles 1131 and 1132 of the KUH Perdata. 3) The utilization of the ex-cultivation rights land on which a mortgage is imposed after it is designated as abandoned land is subject to a delay from BPN RI.
Cancellation of Land Ownership Certificate by the State Administrative Court Reviewed from the State Administrative Justice Law
Authors: Muzakkir Nurul , Rinaldi Yanis , Adwani Adwani
Published: May 2021

Based on Article 32 paragraph (2) of Government Regulation No. 24 of 1997 concerning Land Registration states, in the event that a land area has been issued a certificate legally and on behalf of a person or legal entity who acquires the land in good faith and expressly controls it, then the other party who feels that it has the right to the land, can no longer demand the exercise of the right if within a period of 5 years from the issuance of the certificate does not object in writing to the holder of the certificate or the Head of the Land Office concerned or does not file a lawsuit to the Court regarding the mastery or issuance of the certificate. Legal problems arise that a certificate that has been issued a certificate for 5 years can not be sued in court on an validity basis. The results showed that the cancellation of land rights certificate by tun court based on The State Administrative Court Law, cancellation of land certificates by deliberation and other efforts and unilateral settlement by the National Land Agency (BPN) has been carried out, where the plaintiffs held a review of the State Administrative Decision that has been issued can not be received by the plaintiff or the disputing party. Prior to the ruling that has legal force it remains prohibited for the relevant State Administration officials to carry out mutations on the land in question, it is to avoid the occurrence of problems in the future that cause harm to the litigants and third parties.