bluuebunny/crossref_metadata_2025 huggingface dataset:
Pressing issues of environmental health and medical challenges in Arctic and sub-Arctic regions
Authors:   University of Strasbourg, Faculté de Médecine, Strasbourg, 67000, France, Reis J. , Zaitseva N.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Spencer P. ,   Oregon Health & Science University School of Medicine, Portland, Oregon, 97201, USA
Published: October 2022

The paper concentrates on reviewing results of studies that address the influence exerted by climate change in the Arctic and sub-Arctic regions on local population health, ecological situation and ongoing sanitary-epidemiological processes. The systemic review includes research articles available in PubMed (maintained by The United States National Library of Medicine at the National Institutes of Health), Scopus (the largest abstract and citation database of peer-reviewed literature), WoS (the abstract and citation database of peer-reviewed literature) and BVS (Virtual Health Library) that were published over the period from 1960 to 2021. The review covers pressing environmental, sanitary-hygienic and social issues and identifies priority risk factors for public health and wildlife. Global pollution and communicable diseases are shown to pose threats for indigenous people living in the Arctic. These threats are likely to be greater than those faced by populations living elsewhere in the world. We suggest certain solutions to the existing issues. Our conclusion is that climate is changing faster in the Arctic than anywhere else on the planet. Global pollution and communicable diseases pose threats for public health, including the health of indigenous people living in the Arctic and sub-Arctic regions. It is necessary to intensify cooperation among different states to reduce external influences on the Arctic environment and to maintain public health.
Identification of genetically modified organisms in foods of plant origin as a way to control health risks for consumers
Authors:   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Mukhammadiyeva G.F. , Karimov D.O. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Shaikhlislamova E.R. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Bakirov A.B. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Kudoyarov E.R. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Valova Ya.V. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Daukaev R.A. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation, Repina E.F. ,   Ufa Research Institute of Occupational Health and Human Ecology, 94 Stepana Kuvykina Str., Ufa, 450106, Russian Federation
Published: October 2022

Uncontrolled distribution of goods produced by genetically modified plants should be prevented by the state in order to secure food safety in the Russian Federation and to minimize health risks for consumers. We analyzed foods of plant origin for children to identify components of genetically modified organisms in them. It was done to ensure safety of such foods. The highest specific weight among the analyzed foods belonged to nectars (40.0 %) and juice-containing drinks (36.0 %). Juices and fruit drinks accounted for 12 % each. Genetically modified organisms were determined in foods by identifying regulatory sequences (35S promoter, FMV promoter and NOS terminator) that are widely used in constructions of genetically modified plants. Occurrence of regulatory genetic elements specific for genetically modified organisms was checked in juice products for children by the polymerase chain reaction in real-time mode with hybridization-fluorescent detection of amplification products and with the use of the “AmpliSens GM Plant-1-FL” and “AmpliKvant GM soya-FL” test systems. The results of this study showed that no analyzed foods of plant origin contained any regulatory sequences (35S, NOS и FMV) indicating presence of genetically modified organisms. Fluorescence through the FAM, Cy5 and ROX channels did not exceed its threshold value. Therefore, we did not detect any violations of the established requirements to occurrence of genetically modified organisms in foods for children. Further investigation that would involve examining a more extensive material is required to ensure proper assessment and control of food contamination with genetically modified organisms in order to ensure food safety.
Identification and characterization of 1-hydroxypyrene contents in urine as a marker of exposure to pah in workers of electrolysis workshops at aluminum production
Authors:   East-Siberian Institute of Medical and Ecological Research, 3 12A mikrorayon, Angarsk, 665826, Russian Federation, Shayakhmetov S.F. , Alekseenko A.N. ,   East-Siberian Institute of Medical and Ecological Research, 3 12A mikrorayon, Angarsk, 665826, Russian Federation, Merinov A.V. ,   East-Siberian Institute of Medical and Ecological Research, 3 12A mikrorayon, Angarsk, 665826, Russian Federation, Zhurba O.M. ,   East-Siberian Institute of Medical and Ecological Research, 3 12A mikrorayon, Angarsk, 665826, Russian Federation
Published: October 2022

Potential harmful effects produced by highly toxic aromatic hydrocarbons (PAH) on health of workers employed at aluminum production make it necessary to identify biomarkers of exposure to the toxicants and to assess health risks. Our research goal was to identify and assess contents of 1-hydroxypytene (1-ОНРyr) as a biomarker of exposure to PAH. The chemical was identified in urine of workers from electrolysis workshops where either conventional or updated aluminum production technologies were employed. We comparatively examined contents of the marker metabolite 1-ОНРyr in urine of 142 workers with basic occupations employed at electrolysis workshops with different aluminum production technologies (the test group) and 14 people who were included in the reference group. The chemical was identified with the authors’ high-sensitivity gas chromatography-mass spectrometry method for 1-OHPyr identification in urine with the lower limit of detection being equal to 0.1 µg/l and total error not exceeding 15 %. The research results revealed high 1-ОНРyr contents in urine of workers employed at electrolysis workshops. These contents were by 2–30 times higher than the permissible value of the biological exposure index (BEI) and were associated with exposure to PAH components, an aluminum production technology applied in a given workshop and a worker’s occupation. The highest PAH burdens as per 1-ОНРyr contents in urine and associated health risks were determined for workers who handled anodes of electrolyzers and crane operators in workshops that employed a conventional technology with self-baking anodes. The lowest ones were established for electrolysis operators and anode frame operators in workshops that employed an updated technology with prebake anodes. It is noteworthy that 1-ОНРyr contents were by 2.7–4.7 times higher than permissible BEI value in urine of EOT (bridge) crane operators since these cranes were located in the upper zone of the analyzed electrolysis workshops. Our research results allow us to recommend the inclusion of biological monitoring of 1-OHPyr contents in urine of workers employed at electrolysis workshops of aluminum productions into periodical medical examinations. This is necessary for developing activities aimed at primary and secondary prevention of occupational and work-related diseases.
Life expectancy at birth for the rf population: prediction based on modeling influence exerted by a set of socio-hygienic determinants on age-specific mortality rates exemplified by diseases of the circulatory system
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 6140045, Russian Federation, Glukhikh М.V. , Kleyn S.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Kiryanov D.А. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Kamaltdinov М.R. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation
Published: October 2022

The article dwells on cause-effect relations between certain socio-hygienic factors and age-specific mortality rates due to cardiovascular diseases. New research trends in hygiene, a multidisciplinary approach to studies in the field and the current state policy make the present work topical. Our methodical approach to predicting probable age-specific mortality rates due to cardiovascular diseases relied on applying artificial neural networks. We analyzed a set of indicators that described the public healthcare system, sanitary-epidemiological welfare on a given territory, lifestyle, economic conditions, sociodemographic conditions, and primary incidence. Overall, we obtained 18 models (as per 5-year age-specific periods) of a relationship between socio-hygienic determinants and mortality rates due to cardiovascular diseases. The determination coefficients fell within 0.01–0.75 range and the greatest explanatory power occurred when the age period “30 years and older” was analyzed. We detected comparability of variational series obtained for mortality due to cardiovascular diseases among the whole population and the determination coefficients of the created models. We established predictive estimates of life expectancy at birth (LEB) in case there were changes in the analyzed socio-hygienic determinants by 2024 set within a certain scenario. Thus, changes in the whole set of determinants would result in 514 days added to LEB; lifestyle-related indicators, 205 days; indicators describing sanitary-epidemiological welfare, 126 days; economic indicators, 102 days; sociodemographic indicators, 101 days; primary incidence rates, 40 days; indicators describing the public healthcare system, 19 days. Several determinants were shown to be the most significant for reducing mortality due to cardiovascular diseases among working age population and older age groups. They are indicators describing people’s physical and motor activity, income levels, consumption of vegetables, education, and working conditions. Our research results are consistent with those obtained by other studies with their focus on establishing cause-effect relations between environmental factors and public health.
Forecasting risk analysis of detection for carotid artery stenosis based on serum levels grading of lipoprotein (a)
Authors:   United Hospital with Outpatient Department of the Administrative Department of the President of the Russian Federation, 6 Michurinskii Ave., Moscow, 119285, Russian Federation, Gaisenok O.V.
Published: October 2022

Aim of the study: to assess the relationship between Lp(a) serum levels grading and carotid artery stenosis (CAS). The Duplex Registry database was used for this study. CAS was verified by duplex scanning in the presence of an atherosclerotic plaque (AP), stenosing the lumen of the carotid artery (CA) by 20 % or more. Patients who underwent a blood test for Lp(a) and the results were entered into the registry database were selected for this study. The immunoturbidimetric method was used to determine the serum level of Lp(a) (mg/dl). Data from 51 patients (66.6 % men) were included in the final analysis: median age 49.0 [46.0; 59], total cholesterol (TC) 5.93 [5.13; 6.56], Lp(a) 26.5 [14.2; 76.0]. Spearman rank correlation analysis showed the presence of significant relationships (p < 0.05) between Lp(a) and age (r = 0.3), gender (r = 0.3), the presence of AP in the right ICA (r = 0.5), HDL (r = 0.3). OR and 95 % CI were calculated to determine the effect of Lp(a) grades on the probability of CAS detection: Lp(a) < 30 mg/dl OR 0.36 [0.11; 1.14] p = 0.04; Lp(a) > 30 mg/dl OR 1.42 [0.44; 4.58] p = 0.27. The prevalence of CAS in the group with Lp(a) level < 30 mg/dl was 33.3 %, 30–50 mg/dl – 50 %, 50–100 mg/dl – 40 %, > 100 mg/dl – 37.5 %. The model of multiple regression analysis for Lp(a) with TC in relation to the right ICA stenosis predicting showed R = 0.51, F = 8.4, p = 0.0007. The statistics of 3M model of the logistic regression function for CAS predicting based on the Lp(a) and TC data showed: -2 • log(likelihood) = 57.16, Chi-square = 8.17 (cc = 2), p = 0.016. The present study confirmed the relationship between the Lp(a) level and the CAS detection and the presence of an additive effect of total cholesterol on this. The reference role of Lp(a) gradation at the level of 30 mg/dl was determined as significant in relation to predicting CAS detection.
Informative value of two obesity markers, body mass index (BMI) and lipid accumulation product (LAP), for assessing atherogenic risks in lipid profile: comparative analysis
Authors:   Institute of Physiology of Коmi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Коmi SC UB RAS, 50 Pervomayskaya Str., Syktyvkar, Komi Republic, 167982, Russian Federation, Kaneva A.M. , Bojko E.R. ,   Institute of Physiology of Коmi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Коmi SC UB RAS, 50 Pervomayskaya Str., Syktyvkar, Komi Republic, 167982, Russian Federation
Published: October 2022

The obesity epidemic is a global concern nowadays since obesity is a major risk factor that can cause many serious diseases. A high risk of developing diseases in an obese person primarily occurs due to metabolic disorders. As a rule, dyslipidemia acts as an early sign of metabolic disorders in case of obesity. Our research goal was to compare informative value of body mass index (BMI) and lipid accumulation product (LAP) for assessing atherogenic risks in lipid profile. Two thousand and four hundred people aged 20–60 years took part in our study. We determined participants’ anthropometric and clinical indicators and estimated lipid levels in blood serum. As expected, LAP values had a strong correlation with BMI values. Spearman’s rank correlation coefficient for LAP and BMI values amounted to 0.73 (< 0.001) in men (n = 1168) and 0.77 (< 0.001) in women (n = 1232). However, when we estimated agreement between these two indicators using Cohen’s Kappa coefficient, we established that this agreement between LAP and BMI values was rather low (0.35 for men and 0.39 for women). Having compared samplings with quartiles that differed as per LAP and BMI values, we detected that lipid profiles tended to be more atherogenic in people with LAP values being higher than BMI values. Given this established discordance in the quartiles, higher LAP values are associated with atherogenicity of lipid profile to a greater extent than values of BMI, the conventional obesity indicator. Using solely BMI to diagnose obesity may result in underestimating metabolic disorders in the body. To assess obesity and metabolic health correctly, it is advisable to determine LAP value together with traditional obesity indexes.
ACE I/D genetic polymorphism as a risk factor of essential hypertension
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Starkova K.G. , Dolgikh О.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Kazakova О.А. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Legostaeva Т.А. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation
Published: October 2022

Examining genetic mechanisms of essential hypertension as a cardiovascular risk factor will make it possible to provide monitoring of public health using a personified approach to early diagnostics of cardiovascular pathologies. This will raise effectiveness of preventive activities aimed at reducing population mortality. Our research goal was to examine features of ACE (the angiotensin-converting enzyme) I/D gene polymorphism (rs4646994) as a risk factor of essential hypertension. Our test group included 35 people with diagnosed essential hypertension; the reference group was made of 34 relatively healthy people. Lipid spectrum indicators were estimated with an automated or semi-automated analyzer or by calculation. Insulin and cytokines were determined by using the enzyme immunoassay. Genotyping was performed by using the polymerase chain reaction in real time mode. The research results revealed that the examined patients with essential hypertension had authentic differences from the reference group regarding BMI, lipid spectrum indicators with very low density lipoproteins and triglycerides contents being by 1.3 times higher; insulin contents, by 1.9 times higher; IL-6 contents, by 2.2 times higher; and VEGF, by 1.4 times higher. Genetic analysis revealed 1.3-time higher prevalence of the D-allele of the ACE I/D gene in the patients with essential hypertension (we showed that the dominant inheritance was adequate, P = 0.041). The carriage of this allele was associated with the analyzed disease (OR = 3.16; 95 % CI = 1.08–9.20). We showed an association between insertion-deletion polymorphisms of the ACE (the angiotensin-converting enzyme) I/D gene and developing essential hypertension in the examined test group (the relative risk was RR = 1.87; 95 % CI =1.07–3.61). This polymorphism can be considered a potential marker of sensitivity to developing essential hypertension.
Modeling of enzymatic processes in the duodenum to predict areas with elevated risks of functional disorders
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Kamaltdinov M.R.
Published: October 2022

The present work focuses on developing a model of the duodenum considering motility, biochemical reactions occurring under effects produced by secreted digestive juices, and absorption of reaction products in normal conditions and in case of functional disorders. Analysis of literature sources allowed identifying basic bile components and pancreatic and intestinal juice enzymes influencing fats, proteins and carbohydrates that enter the duodenum. The paper provides a simplified scheme showing how food components are transformed allowing for the neural-humoral mechanism of digestion regulation. Chyme that enters the duodenum is considered a homogenous mixture, which changes its composition during chemical reactions. Mathematical tasking includes mass and momentum conservation equations for a multi-component viscous fluid. The secretion of digestive juices and absorption of components resulting from chemical reactions are described with mass effluents in a pipe in the wall layer. The peristaltic law of the duodenum wall movement was applied to describe the tract motility; the movement characteristics do not depend on the composition of the mixture. Numeric experiments produced necessary results to describe the hydrolysis of the 5 % starch solution under exposure to pancreatic amylase. Obviously, not all the amount of starch enters a chemical reaction and this is well in line with experimental data. The paper provides data on concentration fields for the components of glucose, amylase, and starch at different moments in time and the fluid velocity field. The next stage in the model development is expected to consider absorption of food components, functional disorders of secretion / absorption and intestinal motility as well as influence exerted by neural and humoral mechanisms. In future, the developed model can be applied to predict areas with elevated risks of developing functional disorders, ulcer formation, and other defects of the intestinal mucosa. This will help a physician to prescribe personified therapy and diet.
Organizational communication: a bibliometric analysis from 2005 to 2020
Authors: Clavijo-Tapia Francisco Javier , Duque-Hurtado Pedro Luis , Arias-Cerquera Giovani , Tolosa-Castañeda Maria Alejandra
Published: October 2022

The objective of this article is to perform a systematic review about Organizational Communication from 2005 to 2020, therefore, it is carried out a bibliometric analysis of nets and co-citations of documents published in WoS and Scopus. It uses the tree analogy to separate the documents in: 1. “roots”: the documents located in this section are the intellectual base of a knowledge field, 2. “trunk”: the structural documents, and finally 3. “leaves”: the most recent documents that have cited the authors located in “roots” and “trunk”. Thanks to this scheme it is facilitated the visualization and subsequent analysis of the documents. It should be emphasized that in the process of Organizational Communication review there are some data that complement this article: scientific production by years, scientific production by countries, most cited authors, and sources with the highest number of publications and their relevance. Findings evidence the usefulness of tree analogy to express the epistemological evolution of OC through the years. In addition, the used methodology presents considerable opportunities for the creation of bibliometric analysis, which has applications in different knowledge scientific fields.
Factores que influyen en el desarrollo y la consecución de los resultados empresariales a través de la mentoría
Authors: Orrego-Chica John Alexander , Vieira-Salazar Jaime Andrés
Published: October 2022

La mentoría se entiende como un procedimiento para incrementar habilidades y competencias, mejorando la mentalidad empresarial en emprendedores. Este artículo busca explorar, analizar e identificar los factores que influyen en el desarrollo empresarial durante la mentoría, en el emprendimiento, mediante una revisión sistemática de la literatura (en Web of Science®), análisis de redes y citaciones. Se seleccionaron los estudios más relevantes en el tema. Los resultados se filtraron mediante Tree of Science creando la red de citaciones con las referencias encontradas; luego se hizo la correspondiente lectura y análisis de la bibliografía resultante. Son tres las actividades de la mentoría que influyen en los resultados empresariales. Primero, acciones que derivan del mentor y que permiten al aprendiz mejorar habilidades y competencias. Segundo, alinear los modelos de comportamiento empresarial con los rasgos de personalidad de los aprendices les permite cumplir tareas desafiantes relacionadas con la puesta en marcha del negocio. Tercero, los factores que se originan en el contexto de la relación mentor - aprendiz son significativos e influyen en la capacidad del emprendedor para concretar tareas y deberes empresariales. Identificar estas actividades contribuye en el diseño de programas de mentoría para promover adecuadas diadas mentor - aprendiz.
panorama de los profesores universitarios en Colombia respecto a sus competencias digitales
Authors: Torres-Flórez Dagoberto , Diaz-Betancour Diana Maritza
Published: October 2022

Las tecnologías de la información y la comunicación (TIC), en lo que respecta a temas de educación actual, están inmersas en distintos aspectos, que traen consigo nuevos retos a través de los cuales se persiguen como objetivos el incentivar, impulsar y mejorar las actividades de enseñanza-aprendizaje. El profesor busca desarrollar habilidades digitales a través de su práctica profesional, lo cual le permite afrontar desafíos y de esta forma prepararse y preparar a sus estudiantes para esta nueva sociedad del conocimiento y de esta manera adquirir competencias con enfoque digital, comprendiéndolas como una oportunidad de crecimiento profesional. El presente proyecto investigativo se realizó bajo el enfoque descriptivo y relacional que aporta a la comprensión de la información, determinando causales socio-demográficas, competencias actitudinales, de conocimiento y habilidad, aportando elementos de valor para el desarrollo del proceso de aprendizaje aprovechando al máximo los recursos que ofrecen las TIC, se encontró que no hay diferencias en el desarrollo de las competencias por sexo y por edad y que la creación de contenidos se convierte en una oportunidad para mejorar.
Efectos de Salinidad de tres Cultivares de Mandarina en dos Patrones diferentes
Authors: Velásquez R. , Burga C. , Vargas L.
Published: October 2022

Cítricos, es uno de los más importantes cultivos de frutales en el mundo y son susceptibles a sales. Los efectos negativos de las sales generalmente reducen producción y calidad de fruta. Para evaluar los efectos de la salinidad en algunos parámetros de crecimiento, un experimento en invernadero fue conducido con los cultivares ‘Mihowase’, ‘Primosole’ y ‘W. Murcott’ en los patrones ‘Cleopatra’ y ‘Swingle citrumelo’ El experimento fue conducido en la Estación Experimental Agraria (EEA) del Instituto Nacional de Innovación Agraria (INIA), Huaral-Donoso a 90 km al norte de Lima. Las plantas fueron irrigadas con una solución salina ClNa y con una conductividad eléctrica de 0.5 o 4.5 dS/m. Las variables evaluadas fueron caídas de hojas, peso fresco y seco de tallos, hojas y raíces y contenido de agua por las plantas. Los resultados mostraron que el patrón ‘Cleopatra’ es más tolerante que ‘Swingle citrumelo’. Las variedades afectaron todas las variables de los dos patrones, siendo más notorio en la cantidad de pelos absorbentes de las raíces. La selección de plantas de mandarinas para producción debería considerar combinación variedad/patrón.
Kontribusi Terhadap Kuliah Perancangan Mesin Listrik Dalam Pendidikan Teknik Tenaga Listrik Di Indonesia
Authors: Hasanah Rini Nur , - Soeprapto
Published: October 2022

Dalam dunia industri, mesin tak serempak banyak digunakan sebagai penggerak utama. Selain itu, sebagai generator mesin ini memungkinkan pembangkitan energi listrik secara otonom di daerah-daerah terpencil. Mengingat pentingnya peran mesin ini, makalah ini dibuat untuk sedikit memberikan kontribusi dalam kuliah perancangan mesin listrik bagi mahasiswa teknik tenaga listrik pada khususnya. Kontribusi yang diberikan berupa tambahan pemahaman terhadap penerapan teori elektromaknitik dalam perhitungan induktansi bocor cincin ujung rotor sangkar saat perancangan mesin tak serempak. Akan ditunjukkan bagaimana beberapa anggapan penyederhanaan diambil agar memungkinkan proses perhitungan dengan menggunakan teori dasar elektromaknetika. Perhitungan analitik berdasarkan metoda bayangan, yang pada umumnya sudah dipelajari dalam kuliah dasar teori elektromaknitik, dibandingkan dengan perhitungan secara analitik-empirik serta dengan perhitungan menggunakan metoda numerik berdasarkan metode elemen terbatas. Dengan memanfaatkan metoda bayangan, induktansi diperoleh melalui penghitungan fluksi yang tercakup total menggunakan vektor potensial. Sebagai pembanding, induktansi juga telah diperoleh dengan menghitung impedansi cincin. Selanjutnya, perhitungan induktansi menggunakan perangkat lunak berdasarkan metoda elemen terbatas juga telah dilakukan melalui penghitungan energi maupun fluksi. Hasil perhitungan analitik menunjukkan adanya kesesuaian dengan hasil numerik, dengan keuntungan metode bayangan lebih sederhana dan mudah untuk diterapkan dibandingkan dengan metode elemen terbatas yang hingga kini seringkali masih terbentur pada lama proses penghitungan serta keterbatasan daya hitung komputer.
Implementasi Program Indonesia Coral Reef Garden Bali (ICRG BALI)
Authors: Gultom Iqbal Suhaemi , Anggoro T. Danny , Nugraha R. Bambang Adhitya
Published: October 2022

Bali island is one of the international tourism destinations providing the main income from the tourism sector. Pandemic COVID-19 has caused economic disruption to the people in Bali due to travel restrictions so that travelers can not make visits to Bali. The government of Indonesia has attempted to overcome economic disruption caused by pandemic COVID-19 in Bali by launching the National Economic Recovery (PEN) program in the form of coral garden development or what is known as Indonesia Coral Reef Garden (ICRG) Bali. This program is implemented through a labor-intensive scheme that aims to provide an economic stimulant as well as efforts to restore the coral reefs. Based on the analysis, it is obtained lesson learned that economic stimulants can reach more target groups and restoration requires monitoring and maintenance efforts.
Competencias ciudadanas en un modelo de educación flexible apoyado en narrativa hipermedia
Authors: Gómez Cadavid Santiago , Uribe Zapata Alejandro
Published: October 2022

Introduction: Flexible education models are proof that education is in constant transformation and requires meeting needs in context. Objective: This article explores the incidence of a didactic proposal, supported by hypermedia narrative, which allows working on citizenship competencies in a flexible education model designed for the urban context of the Mariscal Robledo Educational Institution in the city of Medellin, Colombia.  Materials and methods: The participants were (14) eighth-ninth grade extra-age students belonging to the Flexible Education Model: Walking in Secondary School. A qualitative design was used, with an exploratory scope, and the sources of information were the workshop, semi-structured interviews and participant observation. Results: The results illustrate that the use of hypermedia narratives, under specific didactic conditions, can be an interesting support resource; in addition, the process carried out gave them constant recognition and motivation, fundamental elements for their leveling based on the age-grade relationship, and that, with this, they continue with their studies. Conclusion: The hypermedia narratives in the teaching of citizenship competencies contribute to improve the permanence opportunities of the students in condition of extra-age and enhance their progress in the school system.
Green Synthesis of Metal-Organic Biohybrid (Mob) Nanomaterials
Authors: Uppu Navya , McMahen Kelly , Khasru Tasneem , DeCoster Mark
Published: October 2022

Green synthesis of nanomaterials endeavors to reduce the use of high energy methods with those that may include lower temperatures and pressures, use of natural products, and bottom-up self-assembly. Here we describe the generation of metal-organic biohybrids (MOBs) with nanoscale features synthesized at physiological (37°C) and room temperature (25°C). These MOBs utilized the naturally occurring amino acid dimer cystine as the biological component, and a series of metals, including copper, silver, and cobalt. The copper- and silver- based nanomaterials generated were distinct in size and shape. Copper formed elongated high-aspect ratio structures which we have named CuHARS. In contrast, the self-assembly of cystine and silver formed nanoparticles which we designate as AgCysNPs, and cobalt formed particles which we designate as CoMOBs. Both cobalt and silver could be combined with copper in the same reaction vessel to carry out green synthesis of different nanomaterials simultaneously. Post-synthesis the polarization of light by CuHARS provided one measure to distinguish the size and shape of different MOBs generated simultaneously.
Stage-Specific Survival in Breast Cancer in Chinese and White Women: Comparative Data Analysis
Authors: Wang Jun , Zhou Juan , Liu Lei , Wu San-Gang
Published: October 2022

Background

Stage-specific survival, according to the eighth edition of the American Joint Committee on Cancer (AJCC) pathological prognostic staging (PPS) on breast cancer (BC), between Chinese and White American women remains unclear.

Objective

This study aimed to assess stage-specific survival in BC between Chinese and White American women according to the eighth AJCC PPS.

Methods

We included Chinese and White American women with BC diagnosed between 2010 and 2018 from the Surveillance, Epidemiology, and End Results database. A chi-square test, the Kaplan–Meier method, a receiver operating characteristic (ROC) curve, and multivariate Cox proportional hazards models were used for data analysis.

Results

We included 376,818 individuals in this study: 369,522 White American and 7296 Chinese. Of them, 149,452 (39.7%) migrated from the seventh AJCC anatomic staging (AS) to the eighth AJCC PPS, 22,516 (6.0%) were upstaged, and 126,936 (33.7%) were downstaged. With a median follow-up duration of 44 months, the 5-year overall survival and cancer-specific survival (CSS) for the entire group were 87.4% and 95.9%, respectively. The seventh AJCC AS (P<.001) and the eighth AJCC PPS (P<.001) could significantly predict the survival outcomes of BC, and multivariate analysis revealed that both staging systems were significant prognostic indicators of CSS. The ROC curve revealed that the PPS had a better discriminating ability than the AS (area under the curve [AUC] 0.769 vs 0.753, P<.001). Similar trends were observed after stratification by the 2 ethnic groups. The eighth AJCC PPS had better discriminating ability than the seventh AJCC AS among both White American (AUC 0.769 vs 0.753, P<.001) and Chinese patients (AUC 0.790 vs 0.776, P<.001). In the seventh AJCC AS, Chinese women had better CSS in stage IA (P=.02), stage IIA (P=.005), and stage IIIB (P=.04) disease than White American women, but no significant CSS was observed in stage IB, IIB, IIIA, and IIIC disease between the 2 ethnic groups. Regarding the eighth AJCC PPS, Chinese women had better CSS in stage IA (P=.002) and IIIA (P=.046) disease than White American women, and CSS was similar in Chinese and White American women in other substages.

Conclusions

The eighth AJCC PPS has a similar discriminative ability between White American and Chinese individuals with BC compared with the seventh AJCC AS. Therefore, the eighth AJCC PPS is also applicable to Chinese individuals with BC.
End Users' Perspectives on the Quality and Design of mHealth Technologies During the COVID-19 Pandemic in the Philippines: Qualitative Study
Authors: Gonzales Aldren , Custodio Razel , Lapitan Marie Carmela , Ladia Mary Ann
Published: October 2022

Background

The COVID-19 pandemic has expanded the use of mobile health (mHealth) technologies in contact tracing, communicating COVID-19–related information, and monitoring the health conditions of the general population in the Philippines. However, the limited end-user engagement in the features and feedback along the development cycle of mHealth technologies results in risks in adoption. The World Health Organization (WHO) recommends user-centric design and development of mHealth technologies to ensure responsiveness to the needs of the end users.

Objective

The goal of the study is to understand, using end users’ perspectives, the design and quality of mHealth technology implementations in the Philippines during the COVID-19 pandemic, with a focus on the areas identified by stakeholders: (1) utility, (2) technology readiness level, (3) design, (4) information, (5) usability, (6) features, and (7) security and privacy.

Methods

Using a descriptive qualitative design, we conducted 5 interviews and 3 focus group discussions (FGDs) with a total of 16 participants (6, 37.5%, males and 10, 62.5%, females). Questions were based on the Mobile App Rating Scale (MARS). Using the cyclical coding approach, transcripts were analyzed with NVivo 12. Themes were identified.

Results

The qualitative analysis identified 18 themes that were organized under the 7 focus areas: (1) utility: use of mHealth technologies and motivations in using mHealth; (2) technology readiness: mobile technology literacy and user segmentation; (3) design: user interface design, language and content accessibility, and technology design; (4) information: accuracy of information and use of information; (5) usability: design factors, dependency on human processes, and technical issues; (6) features: interoperability and data integration, other feature and design recommendations, and technology features and upgrades; and (7) privacy and security: trust that mHealth can secure data, lack of information, and policies. To highlight, accessibility, privacy and security, a simple interface, and integration are some of the design and quality areas that end users find important and consider in using mHealth tools.

Conclusions

Engaging end users in the development and design of mHealth technologies ensures adoption and accessibility, making it a valuable tool in curbing the pandemic. The 6 principles for developers, researchers, and implementers to consider when scaling up or developing a new mHealth solution in a low-resource setting are that it should (1) be driven by value in its implementation, (2) be inclusive, (3) address users’ physical and cognitive restrictions, (4) ensure privacy and security, (5) be designed in accordance with digital health systems’ standards, and (6) be trusted by end users.
The Impact of COVID-19 Lockdown Restrictions on Exercise Behavior Among People With Multiple Sclerosis Enrolled in an Exercise Trial: Qualitative Interview Study
Authors: Palmer Louise C , Neal Whitney N , Motl Robert W , Backus Deborah
Published: October 2022

Background

During spring and summer 2020, US states implemented COVID-19 pandemic restrictions, resulting in the closure of rehabilitation facilities and, with them, some of the clinical trials that were taking place. One such trial was the Supervised Versus Telerehabilitation Exercise Program for Multiple Sclerosis (“STEP for MS”) comparative effectiveness multiple sclerosis (MS) exercise trial. Although 1 study arm was implemented via telerehabilitation, the comparative arm took place in rehabilitation facilities nationwide and was subsequently closed during this time frame. The experience of the STEP for MS participants provides insights into the impact of lockdown restrictions on exercise behavior by mode of exercise delivery (telerehabilitation vs conventional facility based).

Objective

This study sought to understand the impact of COVID-19 lockdown restrictions on exercise behavior among people with MS enrolled in an exercise trial at the time of the restrictions.

Methods

Semistructured phone and video interviews were conducted with a convenience sample of 8 participants representing both arms of the exercise trial. We applied reflexive thematic analysis to identify, analyze, and interpret common themes in the data.

Results

We identified 7 main themes and 2 different narratives describing the exercise experiences during lockdown restrictions. Although the telerehabilitation participants continued exercising without interruption, facility-based participants experienced a range of barriers that impeded their ability to exercise. In particular, the loss of perceived social support gained from exercising in a facility with exercise coaches and other people with MS eroded both the accountability and motivation to exercise. Aerobic exercises via walking were the most impacted, with participants pointing to the need for at-home treadmills.

Conclusions

The unprecedented disruption of COVID-19 lockdown restrictions in spring and summer 2020 impacted the ability of facility-based STEP for MS exercise trial participants to exercise in adherence to the intervention protocol. By contrast, the participants in the telerehabilitation-delivered exercise arm continued exercising without interruption and reported positive impacts of the intervention during this time. Telerehabilitation exercise programs may hold promise for overcoming barriers to exercise for people with MS during COVID-19 lockdown restrictions, and potentially other lockdown scenarios, if the participation in telerehabilitation has already been established.
Vitamin D status among adolescent females with polycystic ovary syndrome
Authors: Pankiv V.I. , Yuzvenko T.Yu. , Pankiv I.V.
Published: October 2022

Background. Polycystic ovary syndrome (PCOS) is a complex disorder affecting the hypothalamic-pituitary-ovarian axis and leading to menstrual irregularities and hyperandrogenism. Studies have suggested that low vitamin D levels may play a role in the pathogenesis of PCOS. There is currently insufficient data regarding association of serum vitamin D levels and PCOS in adolescent females. The purpose of the study was to compare 25-hydroxyvitamin D levels in adolescent females with and without PCOS. Materials and methods. Participants were categorized as having PCOS or as controls based on National Institutes of Health PCOS diagnostic criteria. Exact logistic regression analysis was done to compare normal (≥ 30 ng/mL) versus low (< 30 ng/mL) serum 25(OH)D levels in the PCOS and control groups. Data regarding the participant’s age, body mass index (BMI) percentile, serum 25(OH)D levels, and the season the blood was drawn were recorded in the database. Results. Eighty-two participants (32 were in the PCOS group and 50 were in the control group) met the inclusion criteria and were categorized as either PCOS or control. All participants in PCOS group had BMI greater than the 85th percentile. Therefore, participants with BMI percentile of less than 85th in the control group were excluded from analysis. The mean age of participants was 17.3 years. Vitamin D deficiency and insufficiency were frequently diagnosed in our study population. Sufficient 25(OH)D levels were found in only 7 of 82 participants (8.5 %). The majority of participants with BMI greater than 95th percentile were vitamin D deficient with statistical difference in mean 25(OH)D levels based on each category of BMI percentile. Vitamin D deficiency was noted among 65.6 % of participants with PCOS versus 38.0 % in the control group. The mean serum 25(OH)D level was 16.02 ng/ml in the PCOS group and 22.80 ng/ml in the control group. The difference in 25(OH)D levels between the groups was statistically significant (P = 0.036). Conclusions. Vitamin D deficiency was noted among 65.6 % of participants with PCOS versus 38.0 % in the control group. The mean serum 25(OH)D level was 16.02 ng/ml in the PCOS group and 22.80 ng/ml in the control group.
Effectiveness of the modified scheme for treatment of Н.pylori-associated peptic ulcer of the duodenum in children
Authors: Sorokman T.V. , Moldovan P.M.
Published: October 2022

Background. None of the known regimens for the treatment of H.pylori-associated peptic ulcer of the duodenum (PUD) is 100 % effective. The purpose was to evaluate the effectiveness of the modified comprehensive therapy for Н.pylori-associated peptic ulcer of the duodenum in children. Materials and methods. The study included 66 patients aged 7 to 18 years with Н.pylori-associated PUD in the acute stage. Serum vitamin D levels were measured using the electrochemiluminescence method (Roche Diagnostics GmbH, Mannheim, Germany). The classical method of stool culture was used. The children were divided into three groups: the first — 20 patients who received protocol eradication therapy, the second — 23 children who received modified comprehensive therapy with the inclusion of vitamin D3, the third — 23 patients who received modified comprehensive therapy with the inclusion of vitamin D3 and a synbiotic. Results. The average length of stay in the hospital for patients who received modified therapy with the inclusion of vitamin D3 was reduced by 18.8 %, and in those who received synbiotic additionally — by 23.8 % compared to the first group. During the endoscopic examination conducted after 1 month, the presence of an elongated red scar at the site of the ulcer defect was observed significantly more often in group I (65.5 %) than in groups II (47.8 %) and III (39.1 %), χ2 = 3.87, p < 0.05; after 1 year, 33.3 % of children in group I, 17.3 % in group II, and 8.7 % in group III (p < 0.01) had a recurrence of the disease. The determination of the main indicators for the effectiveness of PUD treatment using a modified scheme showed that the relative risk of disease recurrence will decrease by 0.42 times (χ2 = 3.96, p < 0.05) when vitamin D3 preparation is included in the treatment scheme and by 0.52 times (χ2 = 4.06, p < 0.01) when using vitamin D3 and a synbiotic. Conclusions. 1. Children with Н.pylori-associated peptic ulcer of the duodenum have vitamin D3 deficiency and various disturbances of the intestinal microbiota, which can complicate the course, increase the chronicity of the process, and reduce the effectiveness of anti-Helicobacter therapy. 2. The use of a modified comprehensive treatment for duodenal ulcer associated with H.pylori leads to a reduction in the duration of the main clinical manifestations of the disease, the duration of inpatient treatment of sick children and a decrease in the frequency of recurrence of the disease.
Empowering Leadership in Creativity and Work-Effort: An Elucidation through the Psychological Empowerment and Self- Leadership of the Millennials Generation
Authors: Alif Muhammad Ikhsan , Nastiti Tur
Published: October 2022

The purpose of this article is to elucidate the relations of empowering leadership on creativity and work-effort by using psychological empowerment and self-leadership. This elucidation contributes to fill the void in empirical studies by simultaneously examining the dynamics of relations among empowering leadership, creativity, work-effort, psychological empowerment, and self-leadership. The social exchange theory is applied to theoretically explain the psychological mechanisms among the constructs. As millennials are categorized as a creative generation, this study focuses on discussing the factors influencing their creativity and work-effort, with a specific notion of empowerment. This study is based on survey data (n = 113) of millennial generation employees working in digital start-up creative industries in Indonesia. Partial least squares structural equation modeling (PLS-SEM) is used to estimate the model. Results of the study find that empowering leadership influences employee creativity and work-effort either directly or indirectly through psychological empowerment and self-leadership. More specifically, the psychological empowerment of employees partially mediates the influence of empowering leadership on employee creativity and employee work-effort. Employee self-leadership also partially mediates the effect of empowering leadership on psychological empowerment, creativity, and employee work-effort. This study implies the practical and theoretical application of empowering leadership in the creativity context of the millennial generation.