bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF THE USE OF SOCIAL MEDIA AS A HOTEL CULINARY TREND PROMOTION MEDIA FOR GEN Z
Authors: Hastiningsih Wahyu Tri , Sari A.Anditha
Published: January 2024

One type of trend that is experiencing rapid development is culinary tourism. Culinary trends make food like a subject and a medium. The high demand for culinary makes this trend have good market prospects, especially for Generation Z. It is necessary to carry out studies related to hotel culinary trends to find out the characteristics and behavioral characteristics of Generation Z so that they can provide references regarding appropriate marketing strategies. An understanding of the nature and characteristics is needed to design messages or content for hotel culinary promotions more effectively.

This research was conducted using a quantitative method where the data obtained was obtained from a survey method using online questionnaires through the Google form application. The questions given contain characteristics, sources of information variables, and gen Z behavior variables towards hotel culinary. The target for distributing the questionnaires was Generation Z who came from the island of Java. The distribution of questionnaires is used to measure responses from respondents and facilitate researchers in measuring data.

Gen Z respondents in Java are dominated by women, aged 19-21 years, and students. Most of the Gen Z respondents had stayed at a hotel with a frequency of more than 2 times and stayed for 1 to 2 nights. Hotel culinary information is easily obtained through social media and is a consideration for staying at the hotel. Location and price are factors that Gen Z considers when choosing a hotel. The content and aspects that most influence culinary purchases are promos, tastes, and reviews from previous guests. The package menu that is popular with Gen Z is a buffet with a payment method that is often used, namely cash. The promos that are most in demand and affect the purchase of hotel culinary delights for Gen Z are discount vouchers and buy 1 get 1 promo. The hotel's culinary delights for Gen Z are food from Indonesia, coffee or tea drinks, and salty or sweet snacks. Gen Z prefers to make culinary as a basic need to survive and meet the energy needs to be used in daily activities.
ASSESSMENT OF INDUSTRIAL SUSTAINABILITY IN THE HERBAL AND MEDICINE SECTOR
Authors: Agustri Febrina , Destyarini Normalita , Novira Diana , Dwyanton Fertilio
Published: January 2024

The Ministry of Industry of the Republic of Indonesia is

committed to increasing the competitive position of industry globally from 41st to 39th in the world out of 138 countries recorded by the 2016-2017 Global Competitiveness Report. Sustainability requires careful planning, namely assessment. The herbal medicine and medicine industry is an industry with significant development, absorbing a workforce of 15 million people and continues to grow along with developments in the direction of food, beverages, cosmetics, spas and aromatherapy. This research aims to develop industrial sustainability assessment indicators implemented in the herbal medicine and medicine sector in the city of Surakarta. The method used is the Delphi method to validate indicators, then MCDM to support the decision making process. The MCDM method used is AHP, which assesses and determines the level of industrial sustainability. Respondents in this study are companies with the criteria for a workforce of more than 100 people and are registered with the Ministry of Industry.
ACTIVITY OF INHIBITING THE GROWTH OF STAPHYLOCOCCUS AUREUS ATCC 25923 LEAVES OF DURI SPINACH (AMARANTHUS SPINOSUS LINN. ) USING THE MACERATION METHOD
Authors: Fitriawati Anna , Lestari Vera Fuji , Dwi S Anita
Published: January 2024

Antibacterial is a substance that can inhibit or kill the growth of bacteria. One of the plants that can be used for antibacterial is spinach thorns. Spinach (Amaranthus spinosus Linn.) is a plant originating from the tropical lowlands of America, widely distributed in the tropics and subtropics of Africa, Southeast Asia and in India and even in Indonesia. The purpose of this study was to determine the activity of spinach leaves (Amaranthus spinosus Linn.) on inhibiting the growth of Staphylococcus aureus bacteria by maceration method. This study uses an experimental method. Spinach leaves (Amaranthus spinosus Linn.) were macerated using 70% ethanol solvent. The concentrations used for each method were concentrations of 30%, 40%, 50%, ciprofloxacin positive control and 1% DMSO negative control. Each of these concentrations was tested for antibacterial activity against Staphylococcus aureus using the diffusion and dilution method. The results of the antibacterial activity test by diffusion in the maceration method obtained an average inhibition zone result at a concentration of 30% of 8.73mm, a concentration of 40% of 9.93mm, a concentration of 50% of 11.53mm and a positive control of 12.73mm.
EFFECTIVENESS OF THE KANGAROO METHOD AS A TREATMENT FOR LOW BIRTH WEIGHT BABY (LBWB)
Authors: Ifalahma Darah , Setyorini Catur , Zulfa Rosyidah Muslihatun
Published: January 2024

Low birth weight babies are a risk factor that contributes to infant deaths and births, especially during the perinatal period. The impact of the birth of low birth weight babies affects the quality of future generations, characterized by slow growth and development of children and will have an impact on decreasing intelligence. Conditions that occur in low birth weight babies are that the temperature regulation center is not optimal, brown fat and subcutaneous tissue are thin, inadequate muscle growth and organ immaturity. Conditions like this cause low birth weight babies to experience different physiological responses to babies with normal birth weight. The death of low birth weight babies can be prevented using interventions that are inexpensive, easy to carry out and effective, namely the kangaroo method of care. The kangaroo method is a method of caring for newborns by placing the baby between the mother's breasts so that there is direct contact between the mother's skin and the baby's skin. The kangaroo method of care is an alternative for caring for low birth weight babies so that mothers can easily breastfeed their babies more frequently and exclusively. The aim of the research is to review and recommend kangaroo treatment methods that have a positive impact and can reduce morbidity in low birth weight babies. The search method for relevant articles uses Google Scholar and Garuda databases. Search for articles using predetermined keywords and criteria. Using population, intervention, conclusion, and output (PICO) analysis. Conclusion: The kangaroo method is effective as a treatment for low birth weight babies. The positive effect of the kangaroo method on low birth weight babies is increasing the baby's body weight, maintaining the stability of the baby's physiological responses including increasing body temperature, heart rate frequency and oxygen saturation which are consistently within the normal range, and increasing the mother's confidence in caring for the baby.
FP GROWTH ALGORITHM MODELING FOR PRODUCT INVENTORY ANALYSIS
Authors: Hartanti Dwi , Atina Vihi
Published: January 2024

Pusaka Tani is a shop that provides agricultural needs such as fertilizers, rice seeds and plant medicines. Sales transactions at the Farmer's Library still use a manual system, namely by using notes as proof of sales transactions. The amount of data that accumulates results in less useful data. So that Pusaka Tani cannot know the products that are often purchased by consumers simultaneously which results in many products being sold out without the knowledge of Pusaka Tani which results when consumers are not going to buy these products and products that are rarely purchased by consumers become unsold. The purpose of this study is to model FP Growt in the analysis of product stock supply. In the research conducted, the support value and confidence value used is a minimum support value of 30% and a minimum confidence value of 70%. The results obtained from the research conducted are for the highest lift ratio value of 1.67 and the lowest is 1.09
AUTOMATIC DIABETES DETECTION SYSTEM USING PCA AND FUZZY K-NN
Authors: Permana Yudha Ery , Purwanto Eko , Puspita Indah Ratna
Published: January 2024

In recent years, the prevalence of diabetes has reached alarming levels, necessitating efficient and timely diagnosis for effective management. This research presents an innovative approach to diabetes detection through an automatic system that leverages advanced technologies such as machine learning and medical data analysis. The proposed system aims to streamline the diabetes diagnosis by analyzing various medical data sources. By utilizing a machine learning algorithm, the system seeks to extract meaningful patterns and relationships from these diverse datasets. Key components of the automatic diabetes detection system include data preprocessing, feature extraction, and model training. The system's performance is evaluated using various metrics, such as sensitivity, specificity, accuracy, and f1-score. Overall, the proposed automatic diabetes detection system holds immense promise in revolutionizing the field of diabetes diagnosis.
EMPIRICAL STUDY OF BRAND REGISTRATION AWARENESS BY UMKM
Authors: Destyarini Normalita , Dwi Rahmawati Nadila , Nur Annisa Miftia
Published: January 2024

The business sector can never escape intellectual property. Every business conducted must have intellectual property contained therein. Intellectual property in question can be in the form of trademarks for business actors. In order to protect the economic value of business actors which is a priority value for business actors. For this reason, it is important to socialize and provide guidance to the community of business actors in Surakarta City which is adjusted to the provisions of Law Number 30 of 2000 concerning Trade Secrets and Law Number 20 of 2016 concerning Trademarks and Geographical Indications. The output of the activity is in the form of scientific publications, integration in intellectual property law. courses and uploading videos of activities on the YouTube platform.
OVERVIEW OF THE MEDICAL RECORDS DEPARTMENT STAFF REQUIREMENT BASED ON HEALTHCARE WORKLOAD ANALYSIS METHOD AT UNIVERSITAS SEBELAS MARET HOSPITAL SUKOHARJO IN 2023
Authors: Cahyaningrum Nopita , Ika Wulandari Fitria , Zaenal Abidin Arif , Nur Afitri Agita
Published: January 2024

Universitas Sebelas Maret (UNS) Hospital currently employs 30 staff members in medical records department. The number of the staff exceeds the required workload. The objective of this research is to find out the requirement of medical records staff based on healthcare workload analysis method in UNS Hospital Sukoharjo. This research is a descriptive survey by implementing cross sectional approach. The samples taken are saturated samples. They are 30 staff members in medical records department. Data were collected through interviews and observations. The calculation of the requirement of medical records staff by implementing healthcare workload analysis method shows that 32 employees required in this department: 1 employee as a Head of Medical Records Deparment, 1 employee as a Registration Coordinator, 13 staff in Outpatient Services and Registration of Executive Patients and Online Patient, 4 employees in Emergency and Inpatient Services, 3 employees in Inpatient Assembly, and 4 employees in Outpatient Assembly and Inpatient/Outpatient Coding, and 6 employees in Medical Records Filing. In fact, there are currently 30 employees work in Medical Records Department of UNS Hospital, Sukoharjo. The result of healthcare workload analysis shows that this hospital needs 32 employees in this department. Therefore, it is suggested that the hospital should hire 2 more employees as staff members in Medical Records Department in order to effectively match the workload.
CONSUMER BEHAVIOR AND DEMAND FOR HYDROPONIC VEGETABLES AT VALE FARM HYDROPONIC
Authors: Kurniawan Shidiq , Setiyani Rahmawati , Sepfrian Bimoseno
Published: January 2024

A healthy vegetable cultivation system using hydroponic techniques is a solution to the challenges of urban farmers, as an innovation and increase in the efficiency of the agricultural industry to meet global challenges. Vale Farm Hydroponics is an agricultural business on urban land or urban farming through a hydroponic farming system that carries the farm to table business concept, where it is possible for consumers to get a variety of good quality hydroponic vegetables directly from farmers and producers. This study uses a qualitative analysis method. Research data was obtained through interviews with 30 ValeFarm Hydroponic consumers. The survey was conducted using a questionnaire containing questions about consumer behavior and demand for hydroponic vegetables. The results of the research show that consumer behavior is divided into four stages, namely the introduction stage, the evaluation stage is influenced by various factors, such as emotional factors, rational factors, and environmental factors and the post-purchase stage. The factors that affect demand are prices of other goods, consumer income and consumer predictions about the future. The research results showed that the demand for hydroponic vegetables at Vale Farm Hydroponics was 381 kg/month.
EXISTENCE OF ARTIFICIAL INTELLIGENCE FOR AUTOMATION OF CONTRACT FORMATION BASED ON THEORY CONTRACT LAW
Authors: Prastyanti Rina Arum , Tengpongsthorn Wuthichai
Published: January 2024

Artificial intelligent technology gives rise to contract automation. In contract law, intention is one of the principles of making contracts. In addition, contracts must also be formed based on the results of discussions and meetings of minds which result in accordance with the wishes or desires so that they can be included in a contract. Contract automation through Artificial Intelligent can be called a conflict of fundamental requirements for contract formation. The general contract law that has emerged through Artificial Intelligence does not take into account mental state and does not examine the true thoughts or intentions of the parties. Based on the explanation above this research aim is to find out Artificial Intelligent in contract formation based on the theory of contract law.

Law is conceptualized as a norm or rule that applies in society and becomes a reference for everyone's behavior in normative legal research with the goal of discovering facts that are used as research data relating to the existence of artificial intelligent for automation og contract formation based on contract theory contract law. This research method employs a statutory approach involving a review of all relevant laws and regulations. This type of research is also known as descriptive-analytical research because the findings are presented descriptively and analytically, so this method was chosen

The findings research, contracts formed using artificial intelligence are not legally binding, even if the technology underlying them advances. The technology that underpins them advances. Currently, despite the fact that computer programs or Artificial Intelligence create contracts. There is no authority to support any legal distinction based on the level of human involvement or program complexity. If the common law of contract is to introduce a distinction depending on how the theory of contract law is based on the appearance of the intent of a person or legal entity in making the statements in the contract as intended."Unintended contracts," or contracts that do not arise from the intention of a person or legal entity and are not based on the fairness and trust theory, will be prohibited
THE EFFECT OF SLOW DEEP BREATHING ON REDUCING BLOOD PRESSURE IN ADULTS WITH HYPERTENSION
Authors: Musta’in Musta’in , Indri Wulandari Septiyana , Yuniarti Tri , Irawan Ady
Published: January 2024

Hypertension is a condition where a person experiences blood pressure that exceeds normal blood pressure. Normal blood pressure in adults is 120/80 mmHg. The aim of this study was to determine the effect of the Slow Deep Breathing (SDB) technique on reducing blood pressure in adults with hypertension. The method used in this study was a pre-experimental study design with a total of 30 subjects selected by purposive sampling technique. Blood pressure data was taken before and after SDB intervention for 15 minutes. The results showed that there was a significant effect between SDB and a decrease in blood pressure in the elderly with hypertension (p <0.05). It is hoped that the SDB technique can be used as an alternative non-pharmacological therapy for elderly people with hypertension.
IMPLEMENTATION OF FUZZY INFERENCE SYSTEM (FIS) FOR CARDIOVASCULAR DISEASES PREDICTION
Authors: Sumarlinda Sri , Binti Rahmat Azizah , Awang Long Zalizah binti , Lestari Wiji
Published: January 2024

Abstract- Cardiovascular diseases (CVDs) continue to be a leading cause of mortality worldwide. Early and accurate prediction of CVDs risk is crucial for effective prevention and management. This study presents the implementation of a Fuzzy Inference System (FIS) for predicting suseptibility cardiovascular diseases. The implementation of FIS for the prediction of cardiovascular disease is by determining the membership function for risk factors that influence the susceptibility of the disease. The FIS developed in this study integrates five risk factors, including age, systolic blood pressure, diastolic blood pressure, blood sugar and cholesterol and one output parameter CVDs prediction. The FIS method used Mamdani with 162 rules. Real-world patient data diagnosed with cardiovascular disease is used to train and validate the FIS. Validity testing produces 100% valid data. Testing is carried out using patient data. The method used to validate the results of the FIS implementation is by distributing questionnaires to several paramedics.. These findings provide insights into further refinements of CVD risk modeling and potential applications in clinical practice.
THE ROLE OF THE FARMER WOMEN'S GROUP (KWT) IN INCREASING THE INCOME OF FARMER FAMILIES IN SRAGEN REGENCY
Authors: Lestari Retna Dewi , Sari Intan Lukita , Sari Vinanda Puspita
Published: January 2024

Data analysis to determine the effect of the role of KWT on the family income of farm women is to perform a simple linear regression analysis. Based on the results of the regression test, it is known that the calculated t value on the effect of the role of KWT on the income of farm women's families results is a significant influence between the role of KWT and the income of farmer women's families. The average income of farm women in managing farming activities is Rp 729,200, the income is used to help meet the needs of the family. Based on the results of interviews with farmer women, the income of farmer women from the KWT business unit and their own business is used for school fees, buying daily food needs and social community needs such as social gatherings, garbage dues, and others. The role of farmer women's groups in increasing the income of farm women's families is shown from the many types of businesses run by farm women. The average group of peasant women in Sragen Regency has a business unit as a source of business income. These business units include herbal medicine agribusiness units ranging from cultivation to marketing of herbal products, hydroponic agribusiness, and other business units.
AUTOMATIC ICD TO IMPROVE DIAGNOSIS CODING ACCURACY: A LITERATURE STUDY
Authors: Tominanto Tominanto , Widyaningrum Linda , Khoirunnisa’ Arifah , Anggraini Eva Ayu
Published: January 2024

ICD coding is usually done by a coder who assigns the ICD code according to the Doctor's clinical diagnosis. However, because coders need to master specific skills, such as knowledge in the field of medicine, coding rules, and medical terminology, manual coding can be costly, time-consuming, and inefficient. Based on this, developing a computationally accurate approach to automatic ICD encoding is imperative. This literature study aims to provide an overview of automatic ICD in terms of the dataset and classification method used. The literature study results show that automatic ICD research to improve the accuracy of diagnosis coding has been done and is still a challenge today. Most of the datasets used are the public MIMIC-III dataset, while automatic ICD classification is the current research trend with deep learning. The deep learning algorithms that are widely used include CNN, RNN, and LSTM. The resulting accuracy based on the dataset and classification method is very diverse. Future research still has many opportunities to contribute and improve the correct classification method to improve automatic ICD accuracy.
THE RELATIONSHIP BETWEEN REGULAR ACUPUNCTURE SESSIONS AND DIETARY PATTERN CHANGES IN OBESE PATIENTS
Authors: Dwi Binuko Raafika Studiviani , Agustina Tri
Published: January 2024

The research addresses the issue of understanding the potential influence of acupuncture sessions on dietary choices in obese patients. While acupuncture's effects on various health aspects have been explored, the direct link between acupuncture frequency and dietary patterns remains relatively underexplored, especially within the context of obesity.

The primary objective is to determine whether there exists a significant relationship between the frequency of acupuncture sessions and shifts in dietary consumption patterns. Additionally, the study aims to identify any potential moderating factors, such as individual patient characteristics or demographic variables, that might impact this relationship.

A quantitative methodology is employed to measure and analyze the aforementioned relationships. Data is collected from a sample of obese patients who undergo routine acupuncture sessions. The variables of interest include the frequency of acupuncture sessions, changes in dietary factors (such as protein, fat, fiber, and sugar intake), and any alterations in physical activity levels. A multiple regression analysis is utilized to assess the strength and significance of the relationship between acupuncture session frequency and dietary pattern changes while controlling for potential confounding factors.

results indicate a statistically significant positive correlation between the frequency of acupuncture sessions and the number of attended sessions, suggesting that patients who engage in more frequent sessions tend to attend more of them. However, the influence of other variables like dietary factors and physical activity on session attendance appears limited. These findings suggest that acupuncture session frequency plays a pivotal role in influencing patient participation, potentially overshadowing the impact of other factors within this context.
EFFECT ICT ON E-LEARNING AND SCHOOL BRAND IMAGE
Authors: Widyaningrum Reno Moeliasari , Suryandaro Retno Tanding
Published: January 2024

This study aims to analyze the effect of information and communication technology on e-learning and school brand image. The research method uses a quantitative approach, the sample in this study is vocational school students, the data collection method uses a questionnaire, and the data analysis method uses Structural Equotion Modeling. The results of data analysis show that e-learning is influenced by ICT and e-service quality. E-WOM and student satisfaction are influenced by e-learning, while school brand image is influenced by e-WOM and student satisfaction. This study contributes to the literature by developing a framework for responding to COVID-19.
ANALYSIS OF ELECTRONIC BANKING ( E-BANKING) USERS IN INDONESIA DURING AND AFTER THE COVID-19 PANDEMIC
Authors: Prastiwi Putri Intan , Hanifah Umi
Published: January 2024

The purpose of this study is to examine the differences in the impact of the covid-19 pandemic on electronic banking users. This study used the Wixolcon Test analysis method to test the differences between paired data. Testing comparisons between observations before and after being given treatment and knowing the effectiveness of a treatment. The dependent variables in this research are mobile banking, internet banking and the dependent variable is the covid-19 pandemic. This research uses a quantitative research approach. The data source is from the official website of the Indonesian Stock Exchange, namely www.idx.co.id in 2019 - 2022. The total research population was 47 companies. The sampling method was purposive sampling so that a total sample of 39 companies was obtained. The results of the Wixolcon test, namely on the mobile banking variable, show that there are differences in mobile banking users in Indonesia during and after the Covid-19 pandemic. Regarding the internet banking variable, the results of internet banking research show that there are differences in internet banking users in Indonesia during and after the Covid-19 pandemic.
CORRELATION BETWEEN THE ACCURACY OF MEDICAL TERMINOLOGY AND DIAGNOSTIC CODES FOR RESPIRATORY CASES IN HOSPITAL INPATIENTS
Authors: Utami Yeni Tri , Wariyanti Astri sri , Susilowati Sheilla
Published: January 2024

Accuracy of writing terminology medical necessary to get accurate diagnosis code. Based on results studies introduction to document record medical patient take care Inpatient diagnosis of respiratory cases carried out at Mitra Pedan General Hospital was found to be 60% inaccurate medical terminology and 40% diagnostic code inaccuracies. This research aims to determine the relationship between accuracy in writing medical terminology and accuracy respiratory case diagnosis code for the patient take care stay. Deep method study This namely analytics with a retrospective approach. Amount population 530 documents with sample a total of 229 documents use proportionate stratified random sampling technique. Research instruments include observation guidelines, interview guidelines, checklists, and ICD – 10. Data management by editing, coding, classification, tabulation, cleaning, and data presentation. Analysis using univariate and bivariate. Accuracy writing diagnoses in respiratory cases was more than 140 documents (61%). big rather than inaccuracy as many as 89 documents (39%). For accuracy accurate respiratory case diagnosis code more than 195 documents (85%). big than inaccuracy as many as 34 documents (15%). Data is processed with the Chi-Square statistical test using SPSS, the p value is = 0.149 so p> 0.05. In conclusion namely H0 accepted and Ha rejected, meaning that there is no connection between accuracy of writing medical terminology with accuracy of respiratory case diagnosis codes at Mitra Pedan General Hospital in 2022. This because in handle inaccuracy writing medical terminology, coding officers will confirm directly with doctor so that the resulting diagnosis code still accurate.
DIGITAL MARKETPLACE IN SMEs SUSTAINABILITY
Authors: Oktaviani Intan , Triana Triana
Published: January 2024

The application of the K-Means algorithm in digital marketplaces is an effective data analysis strategy for grouping customers, products or reviews based on certain characteristics. In the context of digital marketplaces, K-Means is used to understand customer behavior, improve the shopping experience, and optimize business operations. This article describes the basic concept of implementing K-Means in a digital marketplace, including implementation steps and benefits that can be obtained. This method helps marketplaces in customer segmentation, product recommendations, sentiment analysis, and data-driven decision making. By using K-Means, digital marketplaces can optimize marketing strategies, product and service offerings, and increase overall customer satisfaction. In conclusion, the K-Means algorithm is an important tool in data analysis that supports the growth and success of digital marketplaces in the ever-developing digital era.
INCREASING SALES WITH THE ROLES OF MARKETING MIX (A STUDY OF THE COSMETICS BUSINESS)
Authors: Nur Muftiyanto1 R.Taufiq , Hastuti Indra
Published: January 2024

Marketing mix is one method of winning an edge that makes sense for both organizations producing labor and products. The advertising mix is intended to determine the direction, the purpose of promotional options in the business related to market division, the idea of the target market, and the components of the marketing mix. Sometimes business in cosmetics tends to continue to grow. The growing interest in beautifying themselves has become a basic human need, having an impact on increasing the supply of cosmetic products. In the promotional role, the most difficult condition is to restrain the buyer from continuing to use the goods of the merchant, or it is often alluded to as client devotion. To ensure customer constancy, business people must have the right marketing procedures in promoting their products. One type of marketing techniques is a marketing mix system that combines products, prices, promotions, and places. If buyers are satisfied with the goods sold, they will be loyal. Assuming the reliability of the client is understood, it will affect the expansion of the deal.
THE ROLE OF SOCIAL MEDIA MARKETING ON BRAND AWARENESS AND STUDENT DECISIONS TO CHOOSE UNIVERSITY
Authors: Yoga Kharisma Alfin , Haryono Tulus
Published: January 2024

This study is aimed to analyze the influence of social media marketing activities on brand awareness and students' decisions in choosing higher education institutions. The population in this study was students of Universitas Duta Bangsa, data collection methods using online questionnaires, and data analysis methods using SEM-PLS. The results of this study found that marketing activities through social media have a positive effect on the decision to choose a university. The components of social media marketing activities that influence the decision to choose a university are entertainment, interactivity, trendy, customization, and E-WOM. Meanwhile, what affects brand awareness is entertainment, customization, and E-WOM.
INOVAÇÕES NO MANEJO CLÍNICO DA EPIDERMÓLISE BOLHOSA DISTRÓFICA
Authors: Oliveira Nikhole , Mildeberg Carla , Nogueira Küster Emily , Assunção Alvarinho Sepulbeda Gabriella , Evan de Castro Mendes Kamily , Capistrano Pereira Berteli Katrine , Magalhães Chaves Milena , Mendes Veloso Brenda
Published: January 2024

A epidermólise bolhosa distrófica é uma doença rara e hereditária caracterizada pela fragilidade da pele, que ocasiona bolhas na pele devido a pequenos traumas ou atritos, os quais surgem desde o nascimento. Seu manejo clínico baseia-se principalmente em tratamento de suporte sem o propósito de medidas curativas. Portanto, esta pesquisa emerge do questionamento: quais são as atualizações no manejo terapêutico frente a um quadro de epidermólise bolhosa distrófica? Este estudo trata-se de uma revisão de bibliográfica do tipo integrativa de caráter qualitativo e abordagem exploratória. Para compor o estudo, após uma análise criteriosa, foram selecionados 16 artigos. Os principais resultados evidenciaram algumas terapias em ascensão como a injeção intradérmica de fibroblastos, a qual possui uma tendência de maximizar a aderência na junção dermo-epidérmica, além de promover a síntese de colágeno tipo VII. Ainda, a utilização da gentamicina mostrou uma melhora na cicatrização das feridas, maior expressão de colágeno tipo VII e minimização da formação de novas bolhas desses pacientes. Por fim, o uso da losartana, um anti-hipertensivo que proporciona redução na atividade do TGF-β e se usado em associação com trametinibe demonstrou potencializar a sua ação anti-inflamatória sucedendo em atenuação das bolhas e melhora no estado nutricional, sendo notável o progresso clínico do paciente. Portanto, por se tratar de novas terapias farmacológicas, ainda se faz necessário novos estudos para confirmação e maiores delimitações sobre os indivíduos com epidermólise bolhosa que serão beneficiados com o manejo específico segundo a etiologia da doença, além da definição da dosagem dos fármacos em estudo.
COLETE BALÍSTICO E SUA APLICABILIDADE COMO EQUIPAMENTO DE PROTEÇÃO INDIVIDUAL NA ATIVIDADE POLICIAL MILITAR
Authors: Dias Renato Augusto , Sedassari Maike Henrique
Published: January 2024

Esta pesquisa tem como foco principal descrever as características do colete balístico e sua aplicabilidade como equipamento de proteção individual no trabalho do policial militar. O colete salva muitas vidas, mas ao mesmo tempo, se não for adequado ao corpo do policial que está utilizando, pode dificultar o trabalho e causar complicações ao bem-estar. Para tanto, utilizou-se a metodologia de pesquisa bibliografia descritiva em materiais pré-existentes de diversos autores e em periódicos e trabalhos acadêmicos. E após as pesquisas, foi possível constar que os coletes balísticos evoluíram muito desde as primeiras vezes que os homens pensaram em maneiras para se proteger contra os ataques de seus inimigos, e que atualmente oferecem um nível de proteção efetivo para quem os utiliza,  sendo que o Kevlar é o elemento central na constituição dos coletes. Mas, ainda se faz necessário que alguns avanços sejam realizados com relação à adequação dos coletes para que estes possam proporcionar bem-estar para os policiais, sendo que se estes equipamentos estiverem apertados demais podem provocar uma obstrução do fluxo respiratório, e se largos demais atrapalham a movimentação corporal. Assim, fica clara a importância que os coletes balísticos têm como EPIs, que ajudam a salvar a vida dos policiais, mas que ainda são necessários mais estudos para desenvolver um equipamento que proporcione mais conforto e bem-estar para o trabalho policial.
AVALIAÇÃO DA EVIDÊNCIA EM PROCESSO PENAL: IMPLEMENTAÇÃO DO PADRÃO DE PROVA NO CONTEXTO JURÍDICO DO BRASIL
Authors: Gomes Lopes André , Fernandes Carlos José Vieira , Luz Dalton
Published: January 2024

Este artigo tem como foco a investigação da eficácia do critério probatório no Brasil e sua aplicação na análise de evidências em processos criminais. Além disso, aborda-se o nível de certeza necessário para que um juiz possa emitir um veredito de condenação em casos criminais. Inclui também uma discussão sobre o princípio da livre convicção, reconhecido no sistema jurídico brasileiro, que permite ao juiz a autonomia para avaliar as provas apresentadas no processo e formar sua própria conclusão. Este princípio requer que o juiz exponha claramente as razões que o levaram a determinar sua decisão final.
Penderitaan, Hidup Suci, Pengharapan: Tiga Tema Utama dalam Surat 1 Petrus
Authors: Sagala Jenrianto , Surbakti Pelita Hati
Published: January 2024

Penderitaan, kesucian, dan pengharapan merupakan tiga tema yang sangat penting dalam surat 1 Petrus. Bahkan, beberapa ahli mengatakan bahwa ketiganya merupakan tema sentral dalam catatan 1 Petrus. Akan tetapi, berdasarkan sejumlah penelitian-peneitian terdahulu terkait dengan ketiganya, belum ada satu karya tulis pun yang membahas tiga tema penting itu secara bersamaan. Tidak hanya itu, berdasarkan sejumlah penelitian terdahulu, tema pengharapan sepertinya “terabaikan” sebab tidak cukup banyak yang meneliti sebagaimana yang dilakukan para peneliti terhadap dua tema lainnya. Oleh karenanya, dalam tulisan ini penulis hendak melihat ketiganya secara bersamaan, serta mencoba menunjukkan bahwa tema pengharapan sangat layak diberi perhatian yang serius. Untuk mencapai tujuan tersebut di atas, penulis akan melakukan penelitian kualitatif melalui studi kepustakaan serta menguraikan ketiga tema itu satu per satu.
Tinjauan Teologis Hak Waris Perempuan Batak Menurut Bilangan 27:1-11
Authors: Panggabean Kristina
Published: January 2024

Tulisan ini bertujuan untuk mengkaji perjuangan perempuan Batak Kristen dalam mendapatkan keadilan sebagai ahli waris orang tuanya, sesuai dengan ajaran Alkitab, khususnya Bilangan 27:1-11. Dalam masyarakat adat Batak yang menganut sistem kekerabatan Patrilineal, perempuan sering dianggap bukan ahli waris orang tuanya  sehingga dapat menimbulkan konflik ketidakadilan terkait penuntutan hak waris yang diputuskan melalui musyawarah keluarga atau pengadilan. Penulis akan mendekati permasalahan ini melalui kajian Perjanjian Lama, khususnya Bilangan 27:1-11 dan respon gereja saat ini. Penelitian ini akan menggunakan metode penelitian literatur dengan meneliti tulisan-tulisan, dan buku-buku tentang hukum adat Batak, hukum Indonesia yang mengatur hak waris dan Perjanjian Lama khususnya Bilangan 27:1-11. Temuan dalam penelitian ini memperlihatkan bahwa perempuan-perempuan di dalam Sejarah Israel juga berjuang untuk mendapatkan hak waris mereka dari orang tuanya, sehingga pemahaman terhadap teks ini masih relevan dengan perjuangan perempuan Batak Kristen untuk mendapatkan hak waris mereka.
Pilgrimage of Presence: Endledleni Diaconia in Marginalised Communities
Authors: Handel Brian
Published: January 2024

This article explores the concept of Pilgrimage of Presence as an expression of diaconia in marginalised communities in Cape Town, South Africa. Traditionally the diaconal chain is from church to community or from Institution/ Organisation to the recipients of care. This article proposes that diaconia happens in the encounter between the church and the community – the encounter between the organisation and the recipient of care. The author is a pastor of the Uniting Reformed Church in Southern Africa and the diaconal approach of many congregations is that of short term projects (charity projects). There needs to be a shift in social and diaconal work organisations where appropriate, away from being a “supporter” and “provider” towards being a “ acilitator” and “ enabler”. Hence the concept of Pilgrimage of Presence and Endledleni Diaconia  “On the Road Diaconia” where widows and unemployed young adults are placed at the center and recognised as new co – service providers.
Why D3 Is Most Selling Vitamin?
Authors: Patel Vimalkumar
Published: January 2024

Purpose: This whitepaper examines the chemical composition, synthesis, and sources of Vitamin D3, emphasizing the importance of optimal levels for overall well-being. It explores the role of Vitamin D3 in various physiological processes beyond bone health, including immune system support, anti-inflammatory effects, cardiovascular health, cancer prevention, mental well-being, autoimmune disease management, muscle function, weight management, hormone regulation, dental health, and skin health.

Methodology: The document provides a comprehensive overview of natural and dietary sources of Vitamin D3, including supplements. It outlines the synthesis process in the human body, emphasizing the role of magnesium and key enzymes. Popular Vitamin D3 supplements in the U.S. market are also presented.

Findings: Vitamin D3, recognized as the "sunshine vitamin," offers diverse health benefits across multiple systems in the human body. Its popularity stems from advantages beyond bone health, contributing to immune system modulation, anti-inflammatory effects, cardiovascular health, cancer prevention, mental health, autoimmune disease management, muscle function, weight management, hormone regulation, dental health, and skin health.

Unique Contribution to Theory, Policy, and Practice: The paper contributes a comprehensive understanding of vitamin D3's multifaceted benefits, stressing the need for dietary intake and supplementation. It suggests potential implications for public health strategies, especially in regions with limited sunlight exposure.
Evaluación de la hemostasia y heparinización de pacientes neonatos menores a 5 kg de peso sometidos a cirugía cardiovascular con pruebas viscoelásticas y pruebas de coagulación convencionales
Authors: Lopez MS , Rossi Pablo , Vainstein T , Barrera L , Martinuzzo M
Published: January 2024

Introducción: El manejo correcto de la heparinización, la monitorización de la hemostasia y los signos de coagulopatía constituyen desafíos importantes durante la cirugía cardiovascular (CCV) en neonatos. Objetivos: Evaluar el monitoreo de la hemostasia y heparinización de pacientes neonatos con peso <5 Kg sometidos a CCV con pruebas viscoelásticas (PV) y pruebas convencionales (PC). Metodología: Estudio retrospectivo de un único centro en donde se incluyeron neonatos consecutivos sometidos a CCV (octubre 2020 a septiembre 2021). Etapas de la cirugía: basal (B), circulación extracorpórea (CEC) y post protamina (PostProt). PV: tromboelastómetro ROTEM® delta (Werfen). PC: TP % actividad (TP%), APTT, fibrinógeno, tiempo de trombina (TT), recuento de plaquetas (PLT), antitrombina (AT) y actividad antifactor Xa (AntiXa) analizados inmediatamente post heparinización (PostHep), en CEC y PostProt. Medición de PC en coagulómetro ACL TOP con reactivos de Werfen. PLT: HemoCell DXH800 (Beckman Coulter). ACT: realizado mediante el uso del equipo ACT Plus (Medtronic) en quirófano para guiar la heparinización. Estadística: programa SPSS 23. Resultados expresados en mediana y rango intercuartilo (RIC). Resultados: Pacientes: 32 (24 varones). Edad: 19 (6-25) días; peso: 3380 (3082-3785) gramos. Los CT (tiempo de coagulación) y CFT (tiempo de formación del coágulo) de EXTEM, INTEM, FIBTEM y HEPTEM se prolongaron significativamente y A5, A10, MCF (firmezas) fueron menores en CEC comparados con B y PostProt (p<0,001). Los TP% fueron menores y APTT mayores en PostProt comparados con B. CEC presentó los menores PLT. AT en B: 0,56 (RIC 0.46-0.68) UI/mL, ningún paciente recibió suplementos de AT. La mediana de AntiXa fue 6,8 (5,4-7,9) y 5,3 (4,1- 6,9) en PostHep y CEC, respectivamente. PostProt antiXa 0.1 (0.03-0.33), 9/32 >0.2U/mL. AntiXa correlacionó significativamente con EXTEM CT y ACT en CEC, hallándose AntiXa >6 U/mL 10/32 pacientes, pero sólo con TT en PostProt. Sin embargo, PostProt ACT correlacionó con TP%, APTT, INTEM y HEPTEM CT y la relación HEPTEMCT/INTEMCT. La mediana (RIC) de sangrado postquirúrgico a las 12 h fue de 50 (28-91) mL correlacionando significativamente sólo con antiXa y TT en PostProt, y adicionalmente con la heparina total infundida. Conclusiones: El control de la antiXa permitiría una mejor heparinización durante la cirugía y estimación de la heparina residual en PostProt, que correlacionó con un mayor sangrado, no detectada por PC (excepto por prolongaciones moderadas de TT), CT de PV o ACT. Esta estrategia podría ser de utilidad para evitar excesos en la cantidad de heparina infundida que se asociarían a mayores sangrados.
Efficacy of Ozone and Other Alternative Intrauterine Therapies in Infectious Repeat Breeder Cows.
Authors: Ganpatrao Sawale Abhinay , Markandeya Niteen Manmohanrao
Published: January 2024

The study was undertaken to evaluate the therapeutic efficacy of Ozone, E. Coli LPS, Autologous plasma, Neem oil, and Lugol’s iodine in 100 infectious repeat breeder cows. The animals were divided in 5 different groups viz. Group-I, Group-II, Group-III, Group-IV and Group-V treated with Ozone @ 55µg/ml in 60ml distilled water, E. Coli LPS @100mcg in 30 ml sterile PBS, Autologous plasma @ 30 ml, Neem oil @ 10µg/ml in 30 ml distilled water, Lugol’s iodine 1:25 in 30ml normal saline, intrauterine route in 20 cases, respectively, Group-V of 20 animals was kept as control. AI was done in recovered cases. On follow up, recovery rate in treatment group were found as 75.00, 80.00, 65.00, 75.00 and 50.00 per cent in groups I to V, respectively. The conception rate was found as 68.42, 73.68, 55.00, 63.15 and 53.33 per cent in cows in Group-I to V, respectively. Pregnancy rate was observed that 65.00, 70.00, 50.00, 60.00 and 40.00 per cent cows from groups I to V, respectively. On conclusion, infectious repeat breeder cows treated with E. Coli LPS showed highest recovery rate, conception rate and pregnancy rate than the other treatment groups in this research study.
Effect of Adenosine 5´ Triphosphate (ATP) and Incubation Time on Frozen Thawed Buffalo Bull Spermatozoa
Authors: Hanif Misbah , Ahmad Ejaz , Naseer Zahid , Akhtar Muhammad Saleem , Ahmad Tanveer , Hussain Tanveer , Murtaza Saeed
Published: January 2024

The present study was aimed to determine the effect of ATP dose rate on longevity, motility, and viability of frozen-thawed buffalo bull’s sperm. For this purpose, 20 frozen semen straws of four different buffalo bulls were obtained from a private semen production unit (Al-Hiawan Sires, Sahiwal). The experiment was replicated four times. In each replicate, four frozen straws of the same bulls were thawed and pooled. After evaluating the motility, the pooled frozen-thawed sample was aliquoted into three separate tubes containing 0 (control), 1-, or 2-mM concentrations of ATP. Afterward, each aliquot was incubated at 37oC for 4 hrs. The sperm motility, viability, and membrane integrity were observed at various time points (10 min., 1hr, 2hr, and 4hr) during the incubation period of four hrs. It was observed that progressive motility and most of the motion kinematic parameters were greater (P<0.05) in control. A significant (P<0.05) interaction was observed between ATP dose and incubation time. The progressive motility, total motility, VCL, VAP, ALH, and BCF decreased (P<0.05) both by incorporation of ATP (1mM or 2mM) and increasing incubation time (from 10 min to 4hrs) which indicate the ATP and incubation time of 4 hours negatively affect the motion kinetics of buffalo bull sperm. In conclusion, it was witnessed that the motility and plasma membrane integrity of sperm declined by the supplementation of ATP in frozen-thawed buffalo bull semen.
Comparative Study of Antibacterial Activity of Tulsi, Garlic and Commercially used Antibiotics against Bovine Bacterial Endometritis using Molecular Docking Analysis
Authors: Arya Damini , Tyagi Rashmi , Sharma Shingini , Sharma Mridula
Published: January 2024

The present study was conducted with the objective to find effective drug against bacterial bovine endometritis using Molecular docking. The antibacterial property of selected plants was studied and its comparison with conventional antibiotics was done. The plants selected for study were Tulsi and Garlic on the basis of its potent antibacterial activity. Selection of bacteria (S. aureus and E. coli) for the present study was done on the basis of most predominant bacteria causing bovine endometritis as observed in previous studies. The selected bacterial proteins were docked against phytochemicals of plants. Vital proteins of Staphylococcus aureus are Gyrase B (3G75), FtsA (3WQU), DNA ligase (3JSN), Dehydrosqualene synthase (3TFN) and Escherichia coli are FtsZ (6UMK), DNA gyrase (1KZN) and ZapD (5DKO). The docking procedure was carried out using Autodock. It was concluded that,  gentamicin (-6.95 Kcal/mol), enrofloxacin (-6.97 Kcal/mol) and Tulsi (-6.40 Kcal/mol) showed better binding affinity followed by garlic (-3.89 Kcal/mol).  Apigenin, one of the phytoconstituent of tulsi showed the better binding affinity among all the phytochemicals (ranging from -7.2 Kcal/mol to -9.2 Kcal/mol) of garlic and tulsi against targeted bacterial proteins, it can be taken into consideration alone after extraction or in combination therapy. Hence, Tulsi alone or in combination with garlic can be used for further in vivo or in vitro trials in a direction of effective drug discovery against bacterial bovine endometritis.
Dystocia due to Incomplete Cervical Dilatation in Goat and its Non-Surgical Management
Authors: Sharma Renu , Gupta Shashikant , Yadav Brijesh Kumar , Das Goutam Kumar , Jinagal Sujata
Published: January 2024

A four-year-old non-descript doe in her third parity was presented to Referral Veterinary Polyclinic, ICAR-IVRI with a clinical history of failure to deliver kid even after completion of the gestation period. The doe was showing intermittent straining since 24 hours and visual examination could not detect any genital discharge from the vulva. Per-vaginal examination revealed one finger dilatation (external os) indicating that the dystocia was due to insufficient cervical dilation. The induction treatment was advised along with CMC massaging of cervix for 10 minutes at every 30 minutes interval. After 2 hours following therapy, the cervix was fully dilated and first water bag appeared at vulva. Per-vaginal delivery was performed with gentle traction yielding two live fetuses. The doe was recovered uneventfully and treatment with antibiotics and supportive therapy was advised for three days.