bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizations of perfect fluid spacetimes obeying f(ℛ)-gravity equipped with different gradient solitons
Authors: De Krishnendu , Suh Young Jin , De Uday Chand
Published: April 2023

The prime object of this paper is to study the perfect fluid spacetimes obeying [Formula: see text]-gravity, when [Formula: see text]-Ricci solitons, gradient [Formula: see text]-Ricci solitons, gradient Einstein solitons and gradient [Formula: see text]-quasi Einstein solitons are its metrics. At first, the existence of the [Formula: see text]-Ricci solitons is proved by a non-trivial example. We establish conditions for which the [Formula: see text]-Ricci solitons are expanding, steady or shrinking. Besides, in the perfect fluid spacetimes obeying [Formula: see text]-gravity, when the potential vector field of [Formula: see text]-Ricci soliton is of gradient type, we acquire a Poisson equation. Moreover, we investigate gradient [Formula: see text]-Ricci solitons, gradient Einstein solitons and gradient [Formula: see text]-quasi Einstein solitons in [Formula: see text]-gravity, respectively. As a result, we establish some significant theorems about dark matter era.
On the superspecial loci of orthogonal type Shimura varieties
Authors: Wang Haining
Published: April 2023

In this note, we study the superspecial loci of orthogonal type Shimura varieties of signature [Formula: see text] with [Formula: see text]. We prove a conjecture of Gross that the superspecial loci and their lift in the integral models can be parametrized by certain homogeneous spaces. As applications, we provide mass formulas for the superspecial loci. We also indicate how Gross’s conjectures can be proved in the case of Coxeter type Shimura varieties using the group theoretic methods of Görtz and He.
On classification of sequences containing arbitrarily long arithmetic progressions
Authors: Çam Çelik Şermin , Eyidoğan Sadık , Göral Haydar , Sertbaş Doğa Can
Published: April 2023

In this paper, we study the classification of sequences containing arbitrarily long arithmetic progressions. First, we deal with the question how the polynomial map [Formula: see text] can be extended so that it contains arbitrarily long arithmetic progressions. Under some growth conditions, we construct sequences which contain arbitrarily long arithmetic progressions. Also, we give a uniform and explicit arithmetic progression rank bound for a large class of sequences. Consequently, a dichotomy result is deduced on the finiteness of the arithmetic progression rank of certain sequences. Therefore, in this paper, we see a way to determine the finiteness of the arithmetic progression rank of various sequences satisfying some growth conditions.
Zero-free regions for spectral averages of Hecke L-functions
Authors: Ganguly Satadal , Sandeep E. M.
Published: April 2023

We obtain an explicit zero-free region for a weighted sum of [Formula: see text]-functions over the orthogonal basis of Hecke eigen cusp forms of a large integral weight for the full modular group. We also estimate the number of such forms whose [Formula: see text] value does not vanish at a given point inside this zero-free region.
On αg#ψμ*-closed sets and αg#ψμ*-continuous in hereditary generalized topological spaces
Authors: Nandhini T. , Vigneshwaran M.
Published: April 2023

In this paper, we establish the concept of [Formula: see text]-closed sets in Hereditary generalized topological spaces and study some of their basic properties. Further we define [Formula: see text]-continuity and [Formula: see text]-irresoluteness and investigate their properties in hereditary generalized topological spaces.
Magnifiers in various semigroups of transformations that preserve a partition
Authors: Khirabdhi Sushree , Singh Shubh N.
Published: April 2023

Let [Formula: see text] be an arbitrary infinite set, and let [Formula: see text] be a partition of [Formula: see text] indexed by [Formula: see text]. Denote by [Formula: see text] the full transformation semigroup on [Formula: see text], and let [Formula: see text]. The character map of an element [Formula: see text] of [Formula: see text] is the self-map [Formula: see text] defined as [Formula: see text] whenever [Formula: see text]. In this paper, we describe magnifiers in [Formula: see text] in terms of their character and restriction maps. We further describe magnifiers in the subsemigroups [Formula: see text], [Formula: see text], and [Formula: see text] of [Formula: see text] that consist of all transformations whose character maps are injective, surjective, and bijective, respectively.
Tuning dielectric properties of sputtered BaTiO3 thin film capacitors via multilayering with SrTiO3
Authors: Yan Jing , Ouyang Jun , Zhang Yunxiang , Zhang Wei , Cheng Hongbo , Zhu Hanfei , Liu Chao
Published: April 2023

[Formula: see text]/[Formula: see text] (BTO/STO) multilayer films were successfully prepared on (La, Sr)[Formula: see text]-coated (100) [Formula: see text] substrates by using a radio-frequency (RF) magnetron sputtering process at [Formula: see text]C. Benefiting from the flexible deposition configuration of a multi-target sputtering system, we were able to tune the dielectric properties of the multilayer film by varying the number of multilayer periods [Formula: see text] and the individual layer thickness [Formula: see text]. It was found that, in a superlattice-like structure ([Formula: see text]=4 nm, [Formula: see text] 10 unit cells), the dielectric constant increased and the loss tangent decreased with an increasing [Formula: see text], especially in the high frequency range ([Formula: see text]Hz). This can be attributed to a reduced volumetric contribution to the dielectric property from the leaky interface capacitor layer, which lies between the multilayer film and the (La, Sr)[Formula: see text] electrode. On the other hand, as the individual layer thickness [Formula: see text] exceeds the superlattice limit ([Formula: see text]=8 nm, [Formula: see text] 20 unit cells), the superlattice strain effect disappeared and the dielectric constant value dropped by [Formula: see text]50%. However, owing to the reduced number of interfaces and associated defects, the dielectric loss of the multilayer film with a larger period was reduced significantly, as compared to its superlattice counterpart with the same thickness and more periods. The dielectric loss power density of the former was about one order of magnitude lower than that of the latter. These observations provide a solid foundation for using RF magnetron sputtering as an effective method to prepare various forms of multilayer film capacitors for integrated device applications.
A Study of Magnetic and Dielectric Properties for Iron Ion Variation in Cobalt Ferrite
Authors: Bharadwaj S. , Lakshmi Y. Kalyana , Ramya K. , Reddy Ch. Venkata Koti , Pola Someshwar
Published: April 2023

The influence of iron non-stoichiometry variation on structural, magnetic and dielectric properties in Cobalt ferrite is reported. Cobalt ferrite with compositional formula CoFe[Formula: see text]O4 ([Formula: see text], [Formula: see text]) was prepared through sol-gel synthesis route and sintered at 900oC/2[Formula: see text]h. X-ray diffraction confirms the phase evolution of ferrite with additional impurities belonging to [Formula: see text]-Fe2O3 phase and this additional phase disappears for iron deficient sample. The (311) peak shifts towards lower angle for the excess iron sample, whereas it shifts towards higher angle for iron deficient one, confirming the variation in the iron non-stoichiometry. Raman data substantiate the presence of vibrational bands assigned to metal ions in the cobalt ferrites. Change in the peak intensities and peak angle in Raman spectra clearly suggests the movement of cations among octahedral and tetrahedral sites leading to dilution of magnetic character of the samples. Saturation magnetization drastically drops by [Formula: see text]% for iron rich and deficient samples but an improvement in coercivity for the iron deficient cobalt ferrite clearly hints the role of anisotropy. A change in dielectric constant value further alludes to the change of iron ions in different valency states.
A state-dependent dual risk model
Authors: Zhu Lingjiong
Published: April 2023

In a dual risk model, the premiums are considered as the costs and the claims are regarded as the profits. The surplus can be interpreted as the wealth of a venture capital, whose profits depend on research and development. In most of the existing literature of dual risk models, the profits follow the compound Poisson model and the cost is constant. In this paper, we develop a state-dependent dual risk model, in which the arrival rate of the profits and the costs depend on the current state of the wealth process. Ruin probabilities are obtained in closed-forms. Further properties and results will also be discussed.
Risks to the Public
Authors: Neumann Peter G.
Published: April 2023

Considering the risks before you leap seems like a use- ful mantra. Sadly, it seems to be ignored by people who develop automated vehicles, ChatGPT, sensitive uses of arti- cial intelligence, cryptocurrencies, and many other systems that frequentl appear in this section. Almost everything to- day seems to have dual-use issues, in the sense of having both up-sides and down-sides. I believe you all have certainly got- ten that message. However, it needs to reach more widely, Not only is it widely ignored overall, the notion of ground truth seems to have disappeared when it comes to conspiracy theories and rampant disinformation. ChatGPT is just the latest challenge, as noted by the remarkable urry of RISKS posts in this issue largely negative.
Seeing Biomolecular Condensates Through the Lens of Viruses
Authors: Borodavka Alexander , Acker Julia
Published: April 2023

Phase separation of viral biopolymers is a key factor in the formation of cytoplasmic viral inclusions, known as sites of virus replication and assembly. This review describes the mechanisms and factors that affect phase separation in viral replication and identifies potential areas for future research. Drawing inspiration from studies on cellular RNA-rich condensates, we compare the hierarchical coassembly of ribosomal RNAs and proteins in the nucleolus to the coordinated coassembly of viral RNAs and proteins taking place within viral factories in viruses containing segmented RNA genomes. We highlight the common characteristics of biomolecular condensates in viral replication and how this new understanding is reshaping our views of virus assembly mechanisms. Such studies have the potential to uncover unexplored antiviral strategies targeting these phase-separated states.
Visual Functions of the Primate Superior Colliculus
Authors: Hafed Ziad M. , Hoffmann Klaus-Peter , Chen Chih-Yang , Bogadhi Amarender R.
Published: April 2023

The superior colliculus (SC) is a subcortical brain structure that is relevant for sensation, cognition, and action. In nonhuman primates, a rich history of studies has provided unprecedented detail about this structure's role in controlling orienting behaviors; as a result, the primate SC has become primarily regarded as a motor control structure. However, as in other species, the primate SC is also a highly visual structure: A fraction of its inputs is retinal and complemented by inputs from visual cortical areas, including the primary visual cortex. Motivated by this, recent investigations are revealing the rich visual pattern analysis capabilities of the primate SC, placing this structure in an ideal position to guide orienting movements. The anatomical proximity of the primate SC to both early visual inputs and final motor control apparatuses, as well as its ascending feedback projections to the cortex, affirms an important role for this structure in active perception.
[Retracted] FMT Selector: Fourier‐Mellin Transformer with High Speed Rotating in Ship Target Detection and Tracking Based on Internet of Things and Wireless Sensor Network
Authors: Xu Jiaxi , Qiu Changzhen , Wang Luping
Published: April 2023

The terminal guidance tracking always has high speed rotating and scale changing. It makes a large margin of error in current tracking algorithms, which can transmit wrong position in the wireless sensor networks of the Internet of Things. In this paper, we propose a selector based on Fourier‐Mellin transformer, which can accurately track the target with high speed rotating. Firstly we use existing detector to get all proposal target per frame. Then, we use Fourier‐Mellin matching to select the best target in the new frame. Our dataset is the ship video which is created by HRSC2016 in rotating. Experimental results show that the accuracy of this method is up to 89.8%. Compared with other traditional tracking algorithms, it has a leap forward. The FMT selector can be applied to the back end of the detector, and it can achieve a feasible effect in the field of terminal guidance tracking.
A Proposed Supercapacitor Integrated with an Active Power Filter for Improving the Performance of a Wind Generation System under Nonlinear Unbalanced Loading and Faults
Authors: Hamdan I. , Youssef Marwa M. M. , Noureldeen Omar
Published: April 2023

This study proposes the integration of a supercapacitor (SC) with the DC link of a three-phase four-wire active power filter (APF) by using an interfaced three-level bidirectional buck-boost converter controlled by the fuzzy control approach. APF is a flexible alternating current transmission system (FACTS) device that enhances power quality in the electrical network by reducing the load current harmonics and compensating the reactive power. Regulating the DC voltage of the APF’s DC link and absorbing fluctuations in compensated reactive power during disturbances are the major objectives of the integration of an SC circuit to APF. The studied model is a wind farm of Gabal El-Zeit with a total capacity of 580 MW, connected to unbalanced nonlinear loads. The Gabal El-Zeit wind farm is divided into three projects with a capacity of 240 MW, 220 MW, and 120 MW. The model is simulated by the MATLAB/SIMULINK program, and the effectiveness of the proposed methodology is proved by applying different types of faults such as single-line-to-ground, double-line-to-ground, and three-line-to-ground faults. In addition, an additional SC circuit with a two-level converter is connected to the generators coupled to the wind turbines to enhance the performance of the wind farm during disturbances. The results show that SC-integrated APF can reduce the harmonic distortion and compensate the reactive power for high or low inductive loads. Also, it can regulate the DC voltage and absorb the fluctuations in the reactive power during faults. Finally, the performance and the stability of the overall electric system are improved.
Coexistent Relapsing Polychondritis and Clinically Amyopathic Dermatomyositis: A Rare Association of Autoimmune Disorders
Authors: Ríos-Rivera Rafael A. , Vilá Luis M.
Published: April 2023

Relapsing polychondritis (RPC) is an uncommon autoimmune systemic disease characterized by recurrent inflammation of the cartilage tissue. It can occur alone or in association with other autoimmune diseases, vasculitis, or hematologic disorders. However, the association of RPC with dermatomyositis is extremely rare. Herein, we present a case of a 38-year-old man who developed concurrent RPC and clinically amyopathic dermatomyositis (CADM) manifested by auricular chondritis, nasal chondritis, polyarthritis, gottron papules, fingertip papules, skin biopsy consistent with dermatomyositis, and positive antimelanoma differentiation-associated gene 5 (MDA5) antibodies. RPC features resolved with corticosteroids, but CADM manifestations were resistant to corticosteroids, cyclophosphamide, azathioprine, and hydroxychloroquine. Subsequent therapy with rituximab was effective to control CADM manifestations. This case highlights the importance of recognizing CADM as part of the autoimmune diseases linked with RPC and maintaining a high level of awareness to initiate effective therapy to avoid the long-term complications associated with these conditions.
Arthroscopic Treatment of Chronic Cruciate Ligament Rupture in the Dog without Stifle Stabilization: 13 Cases (2001-2020)
Authors: Creamer Danielle G. , Muir Peter
Published: April 2023

Objective. The objective was to study clinical outcomes in dogs with chronic cruciate ligament rupture (CR) treated with palliative arthroscopy as the sole surgical treatment. Methods. Thirteen client-owned dogs with CR underwent physical examination, stifle radiography, and arthroscopy with resection of damaged meniscal tissue. Records were evaluated, and orthopaedic examination, radiographs, and arthroscopy images were assessed. Long-term clinical outcome was also assessed by use of an owner questionnaire. Results. Thirteen dogs that underwent arthroscopy at the UW Veterinary Care between 2001 and 2020 were included. Long-term follow-up was available for 7 of 13 dogs. Lameness was static to improved in all dogs in which arthroscopy was performed. Subsequent stifle stabilization was performed after arthroscopy in only 1 of 7 dogs with follow-up data. Conclusion. Palliative arthroscopy and resection of damaged meniscal tissue in combination with medical management of osteoarthritis can be considered in dogs with chronic CR and cranial tibial subluxation with little passive laxity during examination. Revision surgery with TPLO is uncommon after arthroscopy based on this study.
Energy‐Efficient Resource Scheduling and Computation Offloading Strategy for Solar‐Powered Agriculture WSN
Authors: Gao Juan , Wu Runze , Hao Jianhong , Xu Chen , Guo Haobo , Wang Haonan
Published: April 2023

IoT‐based smart agriculture plays a significant role in building a high‐yield, sustainable, and intelligent modern agriculture. However, limited battery capacity and low‐power processors of sensors cannot accommodate the exponential expansion of data from smart agriculture sensing terminals. To overcome the challenges, we introduced solar harvesting and multiaccess edge computing (MEC) to investigate sustainable monitoring of smart agriculture in solar‐powered MEC‐enabled WSNs. Considering the cyclical and day‐night fluctuations of solar energy, we formulate a joint optimization problem for resource scheduling and computation offloading strategy to maximize the minimum weighted computation capacity across the time slots under solar energy constraints. To solve the mixed‐integer nonlinear program (MINLP), we propose a multiply‐iterated decoupling optimization algorithm by jointly optimizing a computation offloading strategy, energy provision of the solar‐powered hybrid access point (HAP), and local CPU frequency as well as time scheduling. Simulation results show that the proposed algorithm can efficiently use solar energy to balance network calculations, improve network energy efficiency, and realize unmanned and sustainable agricultural WSN.
Odd-Leg Birdcages for Geometric Decoupling in Multinuclear Imaging and Spectroscopy
Authors: Busher Joseph , Touchet-Valle Edith , Sun Chenhao , Wright Steven M. , McDougall Mary P.
Published: April 2023

The utility of interleaved odd-number leg birdcage coils is demonstrated for decoupling in double- and triple-tuned multinuclear applications. The birdcage was designed to geometrically decouple from a planar double-tuned (1H-23Na) array and from a 31P saddle coil insert to create a triple-tuned configuration. Comparisons between an actively detuned coil and a purely geometrically decoupled architecture were used to demonstrate the capabilities of the design. In particular cases, the simplicity and adaptability of the interleaved nine-leg design for multinuclear nuclear magnetic resonance (NMR) offer a straightforward alternative to the often complex and lossy designs currently available for multinuclear birdcages and volume coils.
Roles of Pyroptosis-Related Genes in the Diagnosis and Subtype Classification of Periodontitis
Authors: Cheng Xiaofan , Hu Yifang , Gui Guan , Hu Xiaoya , Zhu Jie , Shi Bowei , Bu Shoushan
Published: April 2023

Pyroptosis is widely involved in many diseases, including periodontitis. Nonetheless, the functions of pyroptosis-related genes (PRGs) in periodontitis are still not fully elucidated. Therefore, we aimed to investigate the role of PRGs in periodontitis. Three datasets (GSE10334, GSE16134, and GSE173078) from the Gene Expression Omnibus (GEO) were selected to analyze the differences in expression values of the PRGs between nonperiodontitis and periodontitis tissue samples using difference analysis. Following this, five hub PRGs (charged multivesicular body protein 2B, granzyme B, Z-DNA-binding protein 1, interleukin-1β, and interferon regulatory factor 1) predicting periodontitis susceptibility were screened by establishing a random forest model, and a predictive nomogram model was constructed on the basis of these genes. Decision curve analysis suggested that the PRG-based predictive nomogram model could provide clinical benefits to patients. Three distinct PRG patterns (cluster A, cluster B, and cluster C) in the periodontitis samples were revealed according to the 48 significant PRGs, and the difference in the immune cell infiltration among the three patterns was explored. We observed that all infiltrating immune cells, except type 2 T helper cells, differ significantly among the three patterns. To quantify the PRG patterns, the PRG score was calculated by principal component analysis. According to the results, cluster B had the highest PRG score, followed by cluster A and cluster C. In conclusion, PRGs significantly contribute to the development of periodontitis. Our study of PRG patterns might open up a new avenue to guide individualized treatment plans for patients with periodontitis.
Figure S7 from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

Figure S7: Analysis of CD46 expression in correlation with of the [225Ac]DOTA-YS5 uptake and DNA damage. Digital autographs, H &E staining, and immunofluorescence (Rabbit Isotype control+DAPI, CD46 & phospho-γ-H2Ax) of the tumor tissues injected with [225Ac]DOTA-YS5 for day 1, day 2, day 4, and day 7.
Figure S7 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
Authors: Jang H. Josh , Hostetter Galen , Macfarlane Alexander W. , Madaj Zachary , Ross Eric A. , Hinoue Toshinori , Kulchycki Justin R. , Burgos Ryan S. , Tafseer Mahvish , Alpaugh R. Katherine , Schwebel Candice L. , Kokate Rutika , Geynisman Daniel M. , Zibelman Matthew R. , Ghatalia Pooja , Nichols Peter W. , Chung Woonbok , Madzo Jozef , Hahn Noah M. , Quinn David I. , Issa Jean-Pierre J. , Topper Michael J. , Baylin Stephen B. , Shen Hui , Campbell Kerry S. , Jones Peter A. , Plimack Elizabeth R.
Published: April 2023

Supplementary Figure 7: Representative IHC staining of additional PD and SD tumors in pre-treatment and post-treatment timepoint from additional patients.
Figure S4 from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

Figure S4: Gamma energy spectra of the tumor, blood, kidneys, and bone showing the intensities of the 213Bi and 221Fr peaks. As compared to the equilibrium gamma energy spectra of [225Ac]DOTA-YS5, increased intensity of the 213Bi was observed in kidney samples.
Figure S3 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
Authors: Jang H. Josh , Hostetter Galen , Macfarlane Alexander W. , Madaj Zachary , Ross Eric A. , Hinoue Toshinori , Kulchycki Justin R. , Burgos Ryan S. , Tafseer Mahvish , Alpaugh R. Katherine , Schwebel Candice L. , Kokate Rutika , Geynisman Daniel M. , Zibelman Matthew R. , Ghatalia Pooja , Nichols Peter W. , Chung Woonbok , Madzo Jozef , Hahn Noah M. , Quinn David I. , Issa Jean-Pierre J. , Topper Michael J. , Baylin Stephen B. , Shen Hui , Campbell Kerry S. , Jones Peter A. , Plimack Elizabeth R.
Published: April 2023

Supplementary Figure 3: Copy number variation detected by SeSAMe from DNA methylation data.
Figure S3 from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

Figure S3: Binding of [225Ac]DOTA-YS5 to 22Rv1 with or without cold antibody blocking. Blocking with cold YS5 results in a reduction of binding from 19.25±0.70% to 4.46±0.17% (n=3).
Figure S2 from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

Figure S2: A, MALDI-TOF Mass spectroscopy results show 8.7 equivalents of DOTA molecules on the YS5 antibody. The number of DOTA were calculated by dividing the difference of m/z between YS5 and DOTA-YS5 by the molecular weight of DOTA. B, Size-exclusion chromatogram shows no aggregation of the [225Ac]DOTA-YS5 after the radiolabeling steps. C, Stability of the [225Ac]DOTA-YS5 tested in saline and human serum for 14 days. D, Comparison of the binding assay results after attaining secular equilibrium vs without secular equilibrium. No significant difference was observed for these two assays (n=4). (Data represented as Mean ± SD).
Figure S12 from A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
Authors: Jang H. Josh , Hostetter Galen , Macfarlane Alexander W. , Madaj Zachary , Ross Eric A. , Hinoue Toshinori , Kulchycki Justin R. , Burgos Ryan S. , Tafseer Mahvish , Alpaugh R. Katherine , Schwebel Candice L. , Kokate Rutika , Geynisman Daniel M. , Zibelman Matthew R. , Ghatalia Pooja , Nichols Peter W. , Chung Woonbok , Madzo Jozef , Hahn Noah M. , Quinn David I. , Issa Jean-Pierre J. , Topper Michael J. , Baylin Stephen B. , Shen Hui , Campbell Kerry S. , Jones Peter A. , Plimack Elizabeth R.
Published: April 2023

Supplementary Figure 12: HLA-DR and NKG2D abundance on peripheral lymphocytes associate with longer progression free survival.
Figure S10 from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

Figure S10: Tumor volumes, overall survival, and body weights for the saline and fractionated dose (0.125 µCi x 3) injections in 22Rv1 xenografts. Results show delayed tumor growth and improved survival without the significant toxicity from fractionated dose treatment (n=10).
Supplemental Tables 1 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
Authors: McDermott Martina S.J. , O'Brien Neil A. , Hoffstrom Benjamin , Gong KeWei , Lu Ming , Zhang Jun , Luo Tong , Liang Min , Jia Weiping , Hong Jenny J. , Chau Kevin , Davenport Simon , Xie Bin , Press Michael F. , Panayiotou Richard , Handly-Santana Abram , Brugge Joan S. , Presta Leonard , Glaspy John , Slamon Dennis J.
Published: April 2023

File containing supplemental data
Supplementary Figure S3 from Increased Nerve Density Adversely Affects Outcome in Oral Cancer
Authors: Perez-Pacheco Cindy , Schmitd Ligia B. , Furgal Allison , Bellile Emily L. , Liu Min , Fattah Aya , Gonzalez-Maldonado Laura , Unsworth Shelby P. , Wong Sunny Y. , Rozek Laura S. , Rao Arvind , Wolf Gregory T. , Taylor Jeremy M.G. , Casper Keith , Mierzwa Michelle , D'Silva Nisha J.
Published: April 2023

This figure show the association of NND with differentiation, Stage, patter of invasion and PNI
Supplementary Figure S2 from Increased Nerve Density Adversely Affects Outcome in Oral Cancer
Authors: Perez-Pacheco Cindy , Schmitd Ligia B. , Furgal Allison , Bellile Emily L. , Liu Min , Fattah Aya , Gonzalez-Maldonado Laura , Unsworth Shelby P. , Wong Sunny Y. , Rozek Laura S. , Rao Arvind , Wolf Gregory T. , Taylor Jeremy M.G. , Casper Keith , Mierzwa Michelle , D'Silva Nisha J.
Published: April 2023

This figure shows that Tongue SCC patients with IND equal or larger than T-AND have poor DSS
Data from Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Bidkar Anil P. , Wang Sinan , Bobba Kondapa Naidu , Chan Emily , Bidlingmaier Scott , Egusa Emily A. , Peter Robin , Ali Umama , Meher Niranjan , Wadhwa Anju , Dhrona Suchi , Dasari Chandrashekhar , Beckford-Vera Denis , Su Yang , Tang Ryan , Zhang Li , He Jiang , Wilson David M. , Aggarwal Rahul , VanBrocklin Henry F. , Seo Youngho , Chou Jonathan , Liu Bin , Flavell Robert R.
Published: April 2023

AbstractPurpose:
Radiopharmaceutical therapy is changing the standard of care in prostate cancer and other malignancies. We previously reported high CD46 expression in prostate cancer and developed an antibody–drug conjugate and immunoPET agent based on the YS5 antibody, which targets a tumor-selective CD46 epitope. Here, we present the preparation, preclinical efficacy, and toxicity evaluation of [225Ac]DOTA-YS5, a radioimmunotherapy agent based on the YS5 antibody.
Experimental Design:
[225Ac]DOTA-YS5 was developed, and its therapeutic efficiency was tested on cell-derived (22Rv1, DU145), and patient-derived (LTL-545, LTL484) prostate cancer xenograft models. Biodistribution studies were carried out on 22Rv1 tumor xenograft models to confirm the targeting efficacy. Toxicity analysis of the [225Ac]DOTA-YS5 was carried out on nu/nu mice to study short-term (acute) and long-term (chronic) toxicity.
Results:
Biodistribution study shows that [225Ac]DOTA-YS5 agent delivers high levels of radiation to the tumor tissue (11.64% ± 1.37%ID/g, 28.58% ± 10.88%ID/g, 29.35% ± 7.76%ID/g, and 31.78% ± 5.89%ID/g at 24, 96, 168, and 408 hours, respectively), compared with the healthy organs. [225Ac]DOTA-YS5 suppressed tumor size and prolonged survival in cell line–derived and patient-derived xenograft models. Toxicity analysis revealed that the 0.5 μCi activity levels showed toxicity to the kidneys, likely due to redistribution of daughter isotope 213Bi.
Conclusions:
[225Ac]DOTA-YS5 suppressed the growth of cell-derived and patient-derived xenografts, including prostate-specific membrane antigen–positive and prostate-specific membrane antigen–deficient models. Overall, this preclinical study confirms that [225Ac]DOTA-YS5 is a highly effective treatment and suggests feasibility for clinical translation of CD46-targeted radioligand therapy in prostate cancer.
Supplementary Table S3 from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Authors: Vujovic Ana , de Rooij Laura , Chahi Ava Keyvani , Chen He Tian , Yee Brian A. , Loganathan Sampath K. , Liu Lina , Chan Derek C.H. , Tajik Amanda , Tsao Emily , Moreira Steven , Joshi Pratik , Xu Joshua , Wong Nicholas , Balde Zaldy , Jahangiri Soheil , Zandi Sasan , Aigner Stefan , Dick John E. , Minden Mark D. , Schramek Daniel , Yeo Gene W. , Hope Kristin J.
Published: April 2023

Table S3 shows clinical information for all AML patient specimens used in this study.
Supplementary Figure S7 from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Authors: Vujovic Ana , de Rooij Laura , Chahi Ava Keyvani , Chen He Tian , Yee Brian A. , Loganathan Sampath K. , Liu Lina , Chan Derek C.H. , Tajik Amanda , Tsao Emily , Moreira Steven , Joshi Pratik , Xu Joshua , Wong Nicholas , Balde Zaldy , Jahangiri Soheil , Zandi Sasan , Aigner Stefan , Dick John E. , Minden Mark D. , Schramek Daniel , Yeo Gene W. , Hope Kristin J.
Published: April 2023

Supplemental Figure S7 shows the expression profile of TOMM34 in normal human bone marrow and across different AML and CML data sets. The effects of TOMM34 depletion on human primary AML cells in vitro and validation of TOMM34 knockdown and overexpression is shown.
Supplementary Figure S6 from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Authors: Vujovic Ana , de Rooij Laura , Chahi Ava Keyvani , Chen He Tian , Yee Brian A. , Loganathan Sampath K. , Liu Lina , Chan Derek C.H. , Tajik Amanda , Tsao Emily , Moreira Steven , Joshi Pratik , Xu Joshua , Wong Nicholas , Balde Zaldy , Jahangiri Soheil , Zandi Sasan , Aigner Stefan , Dick John E. , Minden Mark D. , Schramek Daniel , Yeo Gene W. , Hope Kristin J.
Published: April 2023

Supplemental Figure S6 shows the GSEA of ELAVL1 depletion in mouse RN2c and human primary AML cells, ELAVL1 subcellular localization in mouse and human AML, the qRT-PCR of ELAVL1 targets in MS-444-treated RN2c cells, and the integrative analysis of the mouse RNA-seq and eCLIP-seq.
Supplementary Figure S5 from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Authors: Vujovic Ana , de Rooij Laura , Chahi Ava Keyvani , Chen He Tian , Yee Brian A. , Loganathan Sampath K. , Liu Lina , Chan Derek C.H. , Tajik Amanda , Tsao Emily , Moreira Steven , Joshi Pratik , Xu Joshua , Wong Nicholas , Balde Zaldy , Jahangiri Soheil , Zandi Sasan , Aigner Stefan , Dick John E. , Minden Mark D. , Schramek Daniel , Yeo Gene W. , Hope Kristin J.
Published: April 2023

Supplemental Figure S5 shows the effects of DHTS treatment on THP-1 and human primary AML cells in vitro, the effects of MS-444 treatment on human umbilical cord blood in vivo, and validation of ELAVL1 overexpression by western blot.
Data from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
Authors: Vujovic Ana , de Rooij Laura , Chahi Ava Keyvani , Chen He Tian , Yee Brian A. , Loganathan Sampath K. , Liu Lina , Chan Derek C.H. , Tajik Amanda , Tsao Emily , Moreira Steven , Joshi Pratik , Xu Joshua , Wong Nicholas , Balde Zaldy , Jahangiri Soheil , Zandi Sasan , Aigner Stefan , Dick John E. , Minden Mark D. , Schramek Daniel , Yeo Gene W. , Hope Kristin J.
Published: April 2023

Abstract
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding proteins (RBP) selectively enriched in human AML LSCs. Using an in vivo two-step CRISPR-Cas9 screen to assay stem cell functionality, we found 32 RBPs essential for LSCs in MLL-AF9;NrasG12D AML. Loss-of-function approaches targeting key hit RBP ELAVL1 compromised LSC-driven in vivo leukemic reconstitution, and selectively depleted primitive malignant versus healthy cells. Integrative multiomics revealed differentiation, splicing, and mitochondrial metabolism as key features defining the leukemic ELAVL1–mRNA interactome with mitochondrial import protein, TOMM34, being a direct ELAVL1-stabilized target whose repression impairs AML propagation. Altogether, using a stem cell–adapted in vivo CRISPR screen, this work demonstrates pervasive reliance on RBPs as regulators of LSCs and highlights their potential as therapeutic targets in AML.
Significance:
LSC-targeted therapies remain a significant unmet need in AML. We developed a stem-cell–adapted in vivo CRISPR screen to identify key LSC drivers. We uncover widespread RNA-binding protein dependencies in LSCs, including ELAVL1, which we identify as a novel therapeutic vulnerability through its regulation of mitochondrial metabolism.
Supplemental Figure 6 from Digital Spatial Profiling Links Beta-2-microglobulin Expression with Immune Checkpoint Blockade Outcomes in Head and Neck Squamous Cell Carcinoma
Authors: Gavrielatou Niki , Vathiotis Ioannis , Aung Thazin Nwe , Shafi Saba , Burela Sneha , Fernandez Aileen I. , Moutafi Myrto , Burtness Barbara , Economopoulou Panagiota , Anastasiou Maria , Foukas Periklis , Psyrri Amanda , Rimm David L.
Published: April 2023

expression of immune-related and immune-checkpoint markers in B2M high vs low groups
Data from Digital Spatial Profiling Links Beta-2-microglobulin Expression with Immune Checkpoint Blockade Outcomes in Head and Neck Squamous Cell Carcinoma
Authors: Gavrielatou Niki , Vathiotis Ioannis , Aung Thazin Nwe , Shafi Saba , Burela Sneha , Fernandez Aileen I. , Moutafi Myrto , Burtness Barbara , Economopoulou Panagiota , Anastasiou Maria , Foukas Periklis , Psyrri Amanda , Rimm David L.
Published: April 2023

Programmed cell death protein‐1 (PD-1)-targeted immunotherapy is approved for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treatment. Although its efficacy correlates with PD-L1 expression, response is limited even among positive cases. We employed digital spatial profiling (DSP) to discover potential biomarkers of immunotherapy outcomes in HNSCC. Fifty prospectively collected, pretreatment biopsy samples from patients with anti-PD-1–treated R/M HNSCC, were assessed using DSP, for 71 proteins in four molecularly defined compartments (tumor, leukocyte, macrophage, and stroma). Markers were evaluated for associations with progression-free (PFS) and overall survival (OS). High beta-2 microglobulin (B2M), LAG-3, CD25, and 4-1BB in tumor; high B2M, CD45, CD4 in stroma, and low fibronectin in the macrophage compartment, correlated with prolonged PFS. Improved PFS and OS were observed for cases with high B2M by quantitative and mRNA. Findings were validated in an independent cohort for PFS (HR, 0.41; 95% confidence interval, 0.19–0.93; P = 0.034). B2M-high tumors showed enrichment with immune cell and immune checkpoint markers. Our study illustrates B2M expression is associated with improved survival for immune checkpoint inhibitor (ICI)-treated HNSCC.
Significance:
In the current study, DSP revealed the positive association of B2M expression in the tumor compartment with immunotherapy outcomes in R/M HNSCC.
Glomangiomyoma of the Stomach: Case Report
Authors: Alkhateb Ouwais , Daaboul Obada , Daaboul Bisher , Abouharb Raed , Alazmeh Mhd Anas , Hamed Ghiath
Published: April 2023

Glomus tumor (glomus cell tumor) is a rare, often benign neoplasm, which is, in most cases, seen as a solitary bluish nodule involving the nail beds. Solid glomus tumor, glomangioma, and glomangiomyoma are the three main histopathological variants. In this case report, we present the rarest subtype of a glomus tumor, glomangiomyoma, in an atypical location: the stomach. A 45-year-old female from Syria presented to the clinic with severe dizziness and left epigastric abdominal pain accompanied by melena. We performed a thorough clinical study, laboratory workup, upper gastrointestinal endoscopy, endoscopic ultrasound, CT scan, as well as macroscopic and microscopic histologic examination of the surgical specimen, in addition to the immunohistochemical staining. Although rare, gastric glomangiomyoma was diagnosed and a 4.5 × 3 × 3 cm soft tissue mass was resected from the gastric antrum, and no clinical or endoscopic evidence of recurrence was observed for the follow-up duration of 4 years. Undiagnosed gastric lesions with unexplained symptoms should be further investigated and not be disregarded immediately. To the best of our knowledge, this is only the second report of an instance of gastric glomangiomyoma.
Distribution and Clinical Significance of HPV16 Variants in Head and Neck Squamous Cell Carcinomas: Data from a Portuguese Cohort and Systematic Review
Authors: Cochicho Daniela , Nunes Alexandra , Sobral Daniel , Gomes João P. , Esteves Susana , Mendonça Joana , Vieira Luis , Martins Luís , Cunha Mario , Montalvão Pedro , Magalhães Miguel , Gil da Costa Rui M. , Félix Ana
Published: April 2023

Introduction: Genomic variants of the human papillomavirus type 16 (HPV16) are thought to play differential roles in the susceptibility to head and neck squamous cell carcinomas (HNSCC) and its biological behaviour. This study aimed to establish the prevalence of HPV16 variants in an HNSCC cohort and associate them with clinical pathological characteristics and patient survival. Methods: We retrieved samples and clinical data from 68 HNSCC patients. DNA samples were available from tumour biopsy at the time of the primary diagnosis. Targeted next-generation sequencing was used to obtain whole-genome sequences, and variants were established based on phylogenetic classification. Results: 74% of samples clustered in lineage A, 5.7% in lineage B, 2.9% in lineage C, and 17.1% in lineage D. Comparative genome analysis revealed 243 single nucleotide variations. Of these, one hundred were previously reported, according to our systematic review. No significant associations with clinical pathological variables or patient survival were observed. The E6 amino acid variations E31G, L83V, and D25E and E7 N29S, associated with cervical cancer, were not observed, except for N29S in a single patient. Conclusion: These results provide a comprehensive genomic map of HPV16 in HSNCC, highlighting tissue-specific characteristics which will help design tailored therapies for cancer patients.
Red Blood Cell Membrane-Related Gene Variants and Clinical Risk Factors in Chinese Neonates with Hyperbilirubinemia
Authors: Lin Fen , Xu Jia-Xin , Wu Yong-Hao , Chen Zi-Kai , Chen Man-Tong , Ma Yu-Bin , Li Jian-Dong , Yang Li-Ye
Published: April 2023

Introduction: Neonatal hyperbilirubinemia is common and remains a clinical concern in China. Since neonatal hyperbilirubinemia is linked to genetic factors, we aimed to identify the gene variants of the red blood cell membrane (RBCM) and evaluate the clinical risk factors in Chinese neonates with hyperbilirubinemia. Methods: 117 hyperbilirubinemia neonates (33 cases of moderate hyperbilirubinemia and 84 cases of severe hyperbilirubinemia) and 49 controls with normal bilirubin levels were selected as our study subjects. A customized 22-gene panel with next-generation sequencing (NGS) was designed to characterize genetic variations among the neonates. Sanger sequencing was used to verify the accuracy of the NGS. The clinical risk factors and potential effects of genetic variations in neonates with hyperbilirubinemia were subsequently assessed. Results: After data filtering, suspected pathogenic variants of UGT1A1, SLCCO1B1, and RBCM-associated gene were identified in neonates, the combined numbers of RBCM-associated gene variants were found to have differences between the hyperbilirubinemia group and the controls (p = 0.008), they were also different between severe hyperbilirubinemia and moderate hyperbilirubinemia (p = 0.008), and were correlated with an increased risk of hyperbilirubinemia (odds ratio = 9.644, p = 0.006). The UGT1A1-rs4148323 variant in neonates with hyperbilirubinemia was significantly increased as compared with the controls (p < 0.001). However, there was no statistical difference for the SLCO1B1-rs2306283 variant between the hyperbilirubinemia group and the controls. In addition, breastfeeding contributed to an increased risk of hyperbilirubinemia. Conclusion: Our study highlights that the RBCM-related gene variants are an underestimated risk factor, which may play an important role in developing hyperbilirubinemia in Chinese newborns.
Racial and Ethnic Bias in Letters of Recommendation and Personal Statements for Application to Otolaryngology Residency
Authors: Stack Taylor J. , Berk Garrett A. , Ho Tiffany D. , Zeatoun Abdullah , Kong Keonho A. , Chaskes Mark B. , Thorp Brian D. , Ebert Jr. Charles S. , DeMason Christine E. , Senior Brent A. , Kimple Adam J.
Published: April 2023

Introduction: The persistent lack of racial and ethnic diversity within the field of otolaryngology calls for an analysis of potential bias within the residency application system. Letters of recommendation (LORs) and personal statements (PSs) are the most important subjective application constituents. This subjectivity predisposes these components to implicit bias. In applications to various surgical subspecialties, prior linguistic studies assessing bias in reviews of LOR show race-based differences. Thus far, racial and ethnic linguistic differences in LORs for otolaryngology applicants have not been analyzed in the literature. Methods: LORs and PSs were abstracted from otolaryngology – head and neck surgery applications in the Electronic Residency Application Service for the 2019–20 and 2020–21 application cycles. Linguistic Inquiry and Word Count 2015 was used for quantitative analysis of emotional, cognitive, and structural components of written text. Results: Race-pair analysis of the 2019–2021 application cycles revealed higher mean “teaching” scores for LORs for Asian, black, Hispanic, and white applicants when compared to applicants who self-identified as Other. White applicants had lower scores for the terms “research” and “analytic” when compared to Asian and black applicants, respectively. Analysis of PSs revealed greater scores for an “authentic” writing style for white versus Asian applicants. White applicants were found to have higher scores for “tone” compared to black applicants. Conclusion: Minor racial and ethnic language differences exist in both LORs and PSs. A statistically significant difference was observed among LORs, with the “teaching” term used more frequently for Asian, black, Hispanic, and white applicants compared to self-identified Other individuals. For PSs, statistically significant differences were observed among white applicants, who wrote about themselves using more “authentic” language when compared with Asian applicants and who also had higher scores for “tone” compared to black applicants. Although these differences were statistically significant, the practical impact of the variances is likely small.
Brain-Only Metastasis and 10-Year Survival after Curative Gastric Cancer Resection: A Case Report
Authors: Lee Woo Yong , Yoon Byung Woo
Published: April 2023

Gastric cancer (GC) usually metastasizes to locoregional lymph nodes, the peritoneum causing ascites, or to the liver and lungs but rarely to the brain. Few cases of brain-only GC metastases have been reported, and the prognosis is very poor. We present a case of brain-only metastasis 2 years after curative GC surgery and chemotherapy, who visited the ER due to a headache. The patient underwent operative tumor resection of the brain with additional chemotherapy and is still alive and disease free 10 years after initial curative treatment. This case shows that brain-only metastasis may have a better prognosis than that of systemic metastasis; thus, aggressive treatment with radiotherapy or surgery with chemotherapy may be needed.