bluuebunny/crossref_metadata_2025 huggingface dataset:
Peripheral blood lymphocytes and monocytes heterogeneity in SLE patients treated by Belimumab
Authors: Yang Jinghan , Yan Shushan , Li Haibo , Yang Chunjuan , Zhang Lili , Sun Jiamei , Zhang Jiaojiao , Gao Wenfeng , Xu Donghua
Published: June 2021

Objective: To estimate the effect of Belimumab on the heterogeneity of peripheral blood lymphocytes and monocytes subsets in systemic lupus erythematosus (SLE).Methods: There were three groups of populations, namely health controls (HC, n = 92), SLE patients treated (n = 26) and un-treated with BAFF (n = 155) in the present study. Cell subsets of CD3+T cells, CD3+CD4+T cells, CD3+CD8+T cells, CD19+B cells, CD16+CD56+NK cells, CD14+HLA-DR+monocytes, CD14+CD206+monocytes and CD14+CD163+monocytes were estimated by flow cytometry. Results: Compared with HC group, SLE patients had a higher level of CD3+T cells and CD3+CD8+T cells, but a lower level of CD3+CD4+T cells, CD16+CD56+NK cells, CD14+CD206+monocytes, and CD14+CD163+monocytes. Besides, the ratio of CD3+CD4+/CD3+CD8+T cells was much lower in SLE patients. Belimumab could effectively decrease CD19+B cells but increase CD3+T cell and CD3+CD8+T cells in the peripheral blood of SLE patients. Moreover, SLE patients had decreased CD14+CD206+ monocytes and CD14+CD163+ monocytes in peripheral blood, while Belimumab therapy did not affect the heterogeneity of monocytes in SLE.Conclusions: Our results revealed the heterogeneity of lymphocytes and monocytes in SLE patients. The clinical efficacy of Belimumab in SLE treatment is remarkable due to its significant effect on down-regulating B cell but up-regulating CD3+T cell and CD3+CD8+T cells in SLE.
Photogrammetric Evaluation of Shear Modulus of Glulam Timber Using Torsion Test Method and Dual Stereo Vision System
Authors: Mohamed Ahmed , Deng Yu , Zhang Hexin , Wong Simon H F , Uheida Kal , Zhang Y.X. , Lehmann Martin , Quan Yanfang
Published: June 2021

The shear modulus of timber and timber-based composite materials is a fundamental mechanical property which is used in the design of timber and engineered wood products. The problem of experimentally determining appropriate values of shear modulus for timber-based composite is not as simple and straightforward as in isotropic materials. Although the torsion test is a recommended standard approach to determine the shear modulus of structural-size timber and glulam beams, it is a difficult to measure the rotational deformations of the timber beams. Therefore, in this paper, a stereo camera system combined with a photogrammetric approach is proposed to evaluate the values and variations of the shear modulus of glulam beams under the torsion test. The photogrammetric approach is a non-contact method which provides an efficient and alternative approach for measuring the deformations of the torsion specimens in three dimensions. A series of experiments were conducted on glulam timber beams under the torsion test to investigate the applicability of the optical approach to evaluate the values and variations of shear modulus as well as to investigate the effect of applying torques in a clockwise or anticlockwise direction on the shear modulus of the beams. This optical system not only allows the performance and reliability of the traditional sensors to be assessed, but also allows the rotational deformation of the torsion samples to be monitored at various locations. This enables the values of shear modulus at different cross-sections of the torsion specimens to be evaluated without the need to use more devices. The test results showed that applying torques to the glulam timber specimens during loading and unloading in either a clockwise or anticlockwise direction does not influence or cause a significant change in the shear modulus of the beams. By comparing shear modulus values of glulam beams measured based on different shear spans, it was found that the larger the shear span the smaller the shear modulus value. This might indicate that the variations of shear modulus values at these different gauge lengths needs to be considered.
Justification of Universal Iron Supplementation for Infants 6-12 months in Regions with a High Prevalence of Thalassemia
Authors: Sinlapamongkolkul Phakatip , Surapolchai Pacharapan , Viprakasit Vip
Published: June 2021

Background
Many clinicians hesitate adopting a universal infant iron supplementation program due to the risk of increased iron absorption for those with thalassemia. We aimed to determine thalassemia prevalence in 6- to 12-month old infants, along with the iron status of those with and without thalassemia.
Procedures:
We performed a cross-sectional descriptive study of infants attending the Well Baby Clinic at Thammasat University Hospital for routine checkups. Complete blood count, hemoglobin electrophoresis, iron parameters, and molecular genetics for common α- and β-thalassemia were evaluated.
Results
Overall, 97 of 206 (47%) participants had thalassemia minor, the majority having Hb E traits. None had thalassemia intermedia or major. Familial history of anemia or thalassemia presented an increased risk of detecting thalassemia minor in offspring (OR 5.18; 95% CI 2.60-10.33, p = 0.001). There were no statistical differences in transferrin saturation, serum ferritin and hepcidin between iron-replete infants with thalassemia minor and those without. However, one-third of infants with thalassemia minor (31/97) also had iron deficiency anemia (IDA), with a similar risk of having iron deficiency to infants without thalassemia. There was no hepcidin suppression in our infants with thalassemia minor as compared to controls.
Conclusions
Both thalassemia and IDA are endemic to Southeast Asia. Infants with thalassemia minor, particularly with Hb E and α-thalassemia traits, are at risk of IDA. Our short-term universal iron supplementation program for 6 to 12-month old infants does not appear to increase the risk of those with thalassemia minor developing iron overload in the future.
Local injection of anti-cancer drugs in an experimental model of colorectal cancer, a novel scenario to treat invasive neoplasia.
Authors: Lorenzo-Zúñiga Vicente , Bon Ignacio , Ossa Napoleón de la , Bartolí Ramón
Published: June 2021

Purpose: Endoscopic resection of colorectal lesions significantly decreases the risk of colorectal cancer (CRC) incidence and death. Patients with invasive neoplasia or metastatic CRC have an evident poorer prognosis. Next step could be a more personalized treatment strategy, as a targeted therapy by direct injection of active substances in a selected lesion. The aim was to evaluate the efficacy of intratumoral injection of a drug-eluting platform (CoverGelâ) with different anti-cancer drugs in a rat model of azoxymethane (AOM)-induced CRC.Methods: Experimental CRC was induced in 20 rats. Animals were randomized in five groups (four each): CoverGel + Aflibercept (AFL), CoverGel + Bevacizumab (BVZ), CoverGel + Cetuximab (CTX), CoverGel + Panitumumab (PNT) and CoverGel + Irinotecan (IRT). Endoscopic, histological and necrosis score (0-3 scale) test were performed during follow-up to evaluate clinical success. Results: All animals developed invasive neoplasia (NICE 3, JNET 3), 7.2 mm as mean size (range 6-8). Intratumoral injection was feasible in all animals with no adverse events. AFL, an angiogenesis inhibitor agent, in comparison with the other medications (BVZ, CTX, PNT and IRT) obtained the best results: significantly reduction in tumor size (-30% vs. -10%, –3%, +2% and + 2%; p<0.05, respectively) and significantly higher necrosis score (3 vs. 1, 0.3, 0 and 0; p<0.05, respectively). Conclusion: Angiogenesis inhibitors medications produced the higher cell necrosis and reduction in tumor size in an experimental model of CRC. Intratumoral injection of a drug-eluting platform could open a new way to manage invasive CRC.
Air traffic prediction with fuzzy constraints
Authors: Yamamoto N. , Shen Zhou , Yuan H.
Published: June 2021

In view of the deficiencies of poor prediction accuracy, time-consuming and low efficiency of traditional traffic prediction models, fuzzy constraints are introduced into air traffic traffic system to represent some uncertain information in the field of artificial intelligence, and construct a fuzzy constraint-based air traffic flow prediction The fuzzy constraint-based air traffic prediction model is constructed. By analyzing the decision vector, fuzzy parameter vector and fuzzy constraint set, the prediction model is proposed. The air traffic flow prediction model is built by analyzing the decision vector, fuzzy parameter vector and fuzzy constraint set that affect the fuzzy constraint, and proposing the construction process of the prediction model. The experimental results show that the air traffic flow prediction model can be used to predict the air traffic flow. The experimental results show that the improved prediction model is better than the traditional prediction model in predicting air traffic flow. The results show that the improved prediction model has better prediction results, shorter time consumption and higher accuracy than the traditional prediction model.
Hydrogeochemical features of Lake Kotokel
Authors: Angakhaeva N. A. , Plyusnin A. M. , Ukraintsev A. U. , Chernyavskii M. K. , Peryazeva E. G. , Zhambalova D. I.
Published: June 2021

The purpose of this study is to determine the main hydrochemical parameters of Lake Kotokel deep waters, to identify the role of groundwater feeding it, as well as to establish the features of spatial distribution of macro- and microelements in the lake. Field work was carried out during the ice and ice-free seasons. A special sampler was used to take water samples from the bottom of the lake. Water samples were filtered through the filters with a pore size of 0.45 μm at the sampling site. Plastic bottles were used for the water samples for analysis. Polypropylene containers (15 ml) pretreated with 0.1 N nitric acid were used for the water samples for trace elements. The analysis of the macrocomponent composition of water was carried out in a certified Laboratory of Hydrogeology and Geoecology of the Geological Institute of the Siberian Branch of the Russian Academy of Sciences (Ulan-Ude) according to the standard methods intended for fresh and saline waters. Cations (Ca2+, Mg2+, Na+, K+) were determined by atomic absorption, F-, SiO2 – by the colorimetric method, HCO3- , CO32- and Cl- – by the titrimetric method, SO42- – by the turbidimetric method. The analysis of the trace element content was carried out in the Laboratory of Aquatic Microbiology at the Limnological Institute of the Siberian Branch of the Russian Academy of Sciences (Irkutsk) by the method of inductively coupled plasma on Agilent 7500ce quadrupole mass spectrometer. Conducted research made it possible to determine an inhomogeneous chemical composition of lake water associated with the discharge of fissure-vein waters along the faults that bound the depression from the southeast and northeast and intersect the lake water area from the island to the Istok river. The highest content of dissolved substances was recorded in the strait between Monastyrsky island and the western shore of the lake; the maximum values of hydrocarbonate ion and total mineralization were found here. The maximum content of sulfate ion was found in the southern and southeastern parts of the lake. The dispersion in microelement distribution reaches several mathematical orders. The most variable concentration is characteristic of iron, manganese, copper, zinc, lead, phosphorus, molybdenum, tungsten, strontium. Their high contents were found in the lake water within the location of faults of northeast strike. Therefore, the chemical composition of the water of Lake Kotokel is largely formed by fissure-vein waters. This water is discharged along the tectonic faults of the northeastern strike. The research revealed two centers of subaqueous discharge, which are characterized by the formation of two different associations of microelements in the lake water. The composition of microelements in fissure-vein waters is determined by their interaction degrees with rocks.
Hydrogeological precursors of earthquakes and volcanic activations according to observation data in Kamchatka Peninsula wells
Authors: Kopylova G. N. , Boldina S. V.
Published: June 2021

The purpose of the study is generalization of data on the manifestations of hydrogeological earthquake precursors and volcanic activations based on long-term observations in the wells of the eastern part of the Kamchatka Peninsula. The main problem under consideration is the connection between the manifestations of hydrogeological precursors in several wells with the values of the magnitude Mw and epicentral distance of earthquakes to the wells de as well as with the parameters of seismic action in the observation area including specific density of seismic wave energy e and macroseismic intensity of shaking IMSK-64. The study results revealed that hydrogeological precursors in two-four wells had been manifesting for the period from 1 to 9 months before the strongest earthquakes with Mw = 6.6–7.8 at the epicentral distances de = 90–300 km. Such earthquakes were accompanied by the shakings of the intensity of IMSK-64 = 4–6 points. The specific density of seismic energy under such earthquakes was minimum 0.1 J/m3. The hydrogeological precursors were confined to the area for which the ratios of the earthquake epicentral distance de to the maximum linear size of the earthquake source L, km ranged from 1 to 3.7. Using the established relationships between the manifestations of hydrogeological precursors and earthquake parameters, weekly prognostic conclusions were made for expert earthquake prediction councils based on the data of current observations in wells. The well located at the distance of 15 and 20 km from the Koryaksky and Avacha active volcanoes featured the anomalous rise of groundwater pressure before the eruptions in 1991 and 2008– 2009. Therefore, a conclusion can be drawn that observation equipment operating in wells, the study results of hydrogeological precursors of earthquakes and volcanic eruptions as well as their application experience in the work of expert councils can form the scientific and technical basis for the development of geoinformation prediction technology for natural disasters in the Kamchatka Krai.
Analysis of permafrost effect on water exchange processes
Authors: Shepelev V. V.
Published: June 2021

The article focuses on the importance of studying the water exchange role of the permafrost, which currently occupies a quarter of the Earth's land and is 1.5 km deep in some regions, as well as assessing the permafrost impact on the formation of surface and ground water resources and regime. First of all, the permafrost water exchange function is associated with the freezing of water-saturated rocks and thawing of ice-saturated ones. The author gives individual consideration to the water exchange role of the active layer and the effect of the permafrost long-term dynamics on water exchange direction and scale. The water exchange function of the active layer appears due to the seasonal phase transitions of groundwater from a liquid to a solid state and back. Thus, the volume of water formed by the thawing of underground ice accumulated in the active layer in winter has been estimated about 4·1012 m3. In this regard, it is proposed to give cryohydrogenic part associated with the seasonal transitions of groundwater from the liquid to solid state and back in the active layer of the cryolithozone independent consideration within the hydrological (climatic) cycle of the natural water circulation. It is most certain that the permafrost water exchange function is more significant being associated with longterm permafrost development dynamics under the influence of periodic dramatic climate fluctuations. Thus, during the Holocene climatic optimum about 4.5·1015 m3 of underground ice was converted to the liquid phase. The intensity of water formed from the melting of this amount of ice inflowing its surface and underground reservoirs has been estimated about 820 km3 per year. This fact considered, the author proposes to consider the cryolithogenic part separately in the geological cycle of the natural water cycle.
PROCESSAMENTO E APLICAÇÃO DE BIOMATERIAIS POLIMÉRICOS: AVANÇOS RECENTES E PERSPECTIVAS
Authors: Bernardo Marcela , Paschoalin Rafaella , Santos Danilo , Bilatto Stanley , Farinas Cristiane , Correa Daniel , Oliveira Osvaldo , Mattoso Luiz
Published: June 2021

PROCESSING AND APPLICATION OF POLYMERIC BIOMATERIALS: RECENT ADVANCES AND PERSPECTIVES. Biomaterials have been intensively investigated due to the increase in the elderly population and high prevalence of several disorders, such as cardiovascular and orthopedic diseases. Polymeric and composite polymeric materials in combination with different processing techniques, such as electrospinning, solution blow spinning, ultrathin film preparation, and 3D printing are promising for obtaining biomaterials with patient-specific applications. Here, we provide a review on recent advances and perspectives for synthetic and natural polymers as well as composites in the design of biomaterials. After introducing basic information about biomaterials, we describe the fundamentals of manufacturing techniques and highlight possible biomedical applications.
Strategizing of the Digital Kuzbass Region
Authors: Kvint Vladimir
Published: June 2021

In the collective monograph "Strategizing of the Digital Kuzbass Region" digitalization of
the Kuzbass economy is considered as one of the most important tools for implementation of the
Strategy of socio-economic development of Kuzbass region for the period up to 2035. The
monograph substantiates developing and promoting a digital platform for monitoring and
controlling the implementation of strategic priorities, as well as programs for digitalization of
some industries and sectors of Kuzbass region economy, including coal industry, tourism,
financial sector, media system. Perspectives for artificial intelligence and other avant-garde
technologies in the economy of Kuzbass region are also discussed in the monograth.
Efficacy and Safety of PEGPH20 in Pancreatic Cancer: Systematic Review and Meta-analysis
Authors: Solipuram Vinod , Gopalakrishna Harish , Nair Gayatri , Mohan Akhila
Published: June 2021

Introduction:

Pancreatic cancer is an aggressive tumor, and an estimated 57,600 new
cases and 47,050 deaths were reported in 2020 in the US alone. Recent studies have targeted the tumor
microenvironment (TME) for better delivery of systemic chemotherapy, like PEGPH20,
which degrades hyaluronic acid in the extracellular matrix (ECM). A meta-analysis of these Randomized
controlled trials (RCTs) to test the efficacy of PEGPH20 was performed.

Methods:

A systematic search was performed using PubMed, Embase, and Cochrane library without
language limitations from inception to July 30, 2020. A total of 59 articles were identified, and
3 RCTs were included in the final analysis. The primary outcome was progression-free survival
(PFS), and secondary outcomes were overall survival (OS), deaths from adverse events, thromboembolic
events, serious adverse events (SAE), and febrile neutropenia.

Results:

There was no statistically significant improvement in PFS (HR= 0.94; 95%CI (0.79,
1.11)) in the PEGPH20 group when compared to the standard treatment/placebo group. There was
no significant difference among OS (HR= 0.99, 95%CI (0.83, 1.17), deaths from adverse events (RR=
0.97; 95%CI (0.54, 1.73)), thromboembolic events (RR= 1.49; 95%CI (0.92, 2.44)), and febrile
neutropenia (RR= 0.88; 95%CI (0.45, 1.72), but a statistically significant increase in SAE (RR =
1.59; 95%CI (1.01, 2.52) in the PEGPH20 group compared to the placebo group was observed.

Conclusion:

This meta-analysis showed that PEGPH20 did not improve the PFS or OS. Moreover,
there was an increased incidence of serious adverse events using PEGPH20 compared to standard
therapies.
West Nile Viral Meningoencephalitis in an Immunocompetent Female: A Case Report from Western Rajasthan, India
Authors: Abhishek Kumar S , Tiwari Sarika , Kumar Prawin , Nag Vijaya Lakshmi , Pamnani Jaya , Tiwari Sarbesh
Published: June 2021

Background:

West Nile virus (WNV) is a positive-sense single-stranded RNA virus of the
family Flaviviridae and genus Flavivirus. The virus is transmitted primarily by the bite of Culex species
mosquito and is of global concern. The infection is associated with a wide spectrum of signs and
symptoms and is more fatal in the elderly, infants, and immunocompromised individuals.

Case presentation:

We report a case of WNV meningoencephalitis in an immunocompetent female
who presented with features of acute meningitis with a 5-days history. After the radiological suspicion
of viral meningoencephalitis, viral serology was performed and was reactive for IgM antibody against
WNV, delaying the diagnosis for at least 5 days.

Conclusion:

The purpose of this case report is to prime the treating physicians on the usefulness of
viral serology in such a scenario. Viral serology is a simple and relatively rapid technique to diagnose
or rule out the suspected viral cause of meningoencephalitis and minimize the time gap between diagnosis
and start of supporting treatment wherever appropriate antivirals are not available for clinical use.
The Effects of Cannabis with a Focus on the Adolescent and Fetal
Brain
Authors: Chatlos John Calvin , Petti Theodore A.
Published: June 2021

Background:

Knowledge of the effects of cannabis and the endocannabinoid system (ECS) has significantly increased in recent years. This information has been brought into debates and decisions regarding the medical use of cannabis and recreational use of cannabis and cannabinoid products, often with non-science-based conclusions. Health-related effects, especially those related to children, adolescents, and young adults, must be a critical part of the decisions about the legalization of cannabis, and current knowledge is a necessity.
The aim of this study was to provide an overview of cannabis use epidemiology in the United States.
and provide current research information about the effects of cannabis use to be used in decisions about cannabis use and legalization, highlighting impacts on children, adolescents, and young adults.

Method:

Key features of cannabis-related to health benefits and adverse effects were identified to provide a representative collage detailing the knowledge base of health, disease, and public welfare. Emphasis is paid on to the most current research findings and adverse effects related to youth and young adults.

Results:

Helpful and harmful cannabis effects explain contradictory positions taken regarding further legalization of cannabis products. Federal research prohibition has handicapped a timely science-based informed discussion. Concerns are expressed for the protection of adolescents and emerging adults, regardless of cannabis’ legal status.

Conclusion:

The special vulnerabilities and needs of adolescents and emerging adults need to be considered in current and future discussions in public policy and legislation at all levels of government related to any further legalization of cannabis products. (N=247 words).
Corporate Social Responsibility and Financial Performance: Moderating Role of Intellectual Capital
Authors: Iqbal Achmad , T Sutrisno , Roekhudin Roekhudin
Published: June 2021

This study aims to examine the impact of corporate social responsibility (CSR) on corporate performance in Indonesia and examine the role of intellectual capital as a moderating variable that can increase the influence of CSR on company performance. Hierarchical regression analysis is used to test the effect of CSR on performance and test intellectual capital as a moderating variable that can increase the influence of CSR on corporate performance. This study uses 147 samples of observation data from manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the year 2013-2015. The results showed that CSR has an effect on company performance as measured by Return on Asset (ROA). The higher CSR disclosures made by the company then can improve the company's performance (ROA). The results of this study also show that intellectual capital as a moderation variable is proven empirically able to increase the influence of CSR on company performance. These results indicate that the improvement of intellectual capital of the company including human capital, relational capital, and structural capital can increase the influence of CSR on company performance (ROA).
Development of a Positive Body Image Chatbot (KIT) With Young People and Parents/Carers: Qualitative Focus Group Study
Authors: Beilharz Francesca , Sukunesan Suku , Rossell Susan L , Kulkarni Jayashri , Sharp Gemma
Published: June 2021

Background

Body image and eating disorders represent a significant public health concern; however, many affected individuals never access appropriate treatment. Conversational agents or chatbots reflect a unique opportunity to target those affected online by providing psychoeducation and coping skills, thus filling the gap in service provision.

Objective

A world-first body image chatbot called “KIT” was designed. The aim of this study was to assess preliminary acceptability and feasibility via the collection of qualitative feedback from young people and parents/carers regarding the content, structure, and design of the chatbot, in accordance with an agile methodology strategy. The chatbot was developed in collaboration with Australia’s national eating disorder support organization, the Butterfly Foundation.

Methods

A conversation decision tree was designed that offered psychoeducational information on body image and eating disorders, as well as evidence-based coping strategies. A version of KIT was built as a research prototype to deliver these conversations. Six focus groups were conducted using online semistructured interviews to seek feedback on the KIT prototype. This included four groups of people seeking help for themselves (n=17; age 13-18 years) and two groups of parents/carers (n=8; age 46-57 years). Participants provided feedback on the cartoon chatbot character design, as well as the content, structure, and design of the chatbot webchat.

Results

Thematic analyses identified the following three main themes from the six focus groups: (1) chatbot character and design, (2) content presentation, and (3) flow. Overall, the participants provided positive feedback regarding KIT, with both young people and parents/carers generally providing similar reflections. The participants approved of KIT’s character and engagement. Specific suggestions were made regarding the brevity and tone to increase KIT’s interactivity.

Conclusions

Focus groups provided overall positive qualitative feedback regarding the content, structure, and design of the body image chatbot. Incorporating the feedback of lived experience from both individuals and parents/carers allowed the refinement of KIT in the development phase as per an iterative agile methodology. Further research is required to evaluate KIT’s efficacy.
Editorial
Authors: Hall-Lew Lauren
Published: June 2021

Welcome to the first issue of Volume 7 of Lifespans & Styles: Undergraduate Papers in Sociolinguistics. This issue includes five papers by eight authors that continue the journal’s mission of showcasing excellence in undergraduate research in sociolinguistics.
УПРАВЛЕНИЕ ПРЕЦИЗИОННЫМ ЦАП С ИСПОЛЬЗОВАНИЕМ ИЗОЛЯТОРА ЦИФРОВЫХ СИГНАЛОВ
Authors: Брандт Т.
Published: June 2021

В промышленных системах часто требуется реализовать изолированное цифровое управление модулями вывода аналоговых сигналов. В статье описано решение на основе интегрированного изолятора цифровых сигналов для управления прецизионным 16-разрядным ЦАП с токовым выходом и выходом по напряжению.
Currarino Syndrome: lower urinary tract function, treatment plan and outcomes
Authors: Xia Hongliang , Fu Mingcui , Wang Hangzhou , Cao Xu , Yan Xiangming , Zhou Yun , Wang Jian
Published: June 2021

Currarino syndrome (CS) is a rare congenital disorder characterized by anorectal malformation, sacral agenesis and presacral mass. We performed video-urodynamics (VUDS) assessment of patients with CS to characterize the lower urinary tract function, individualize management plans and to follow outcomes. We conducted a cross-sectional study on 11 patients diagnosed with CS at the spina bifida multidisciplinary clinic. Lower urinary tract function was assessed by VUDS from three months to 12 months after neurosurgery. All patients had sacral agenesis; nine patients had anorectal malformation (9/11, 81.8%) and five patients had a presacral mass (5/11, 45.5%). The average age at neurosurgery was 7.9 months (range, 2–19). One patient had bilateral vesicoureteral reflux (VUR) with increasing detrusor pressure at the end of filling. In two patients, the detrusor activity showed weakening during urination, while no other lower urinary tract abnormality was identified on urodynamic evaluation. Six patients underwent VUDS before and after surgery; of these, two patients showed improved bladder function after surgery, while the remaining four patients showed no change in urodynamics. The average duration of follow-up was 27.5 months (range, 9–51). Renal function was normal in all patients. We can conclude that patients with CS often exhibit associated neurological abnormalities. VUDS assessment may help detect lower urinary tract dysfunction at an early stage and facilitate timely urological intervention to avoid kidney damage.
Asociación entre el “food craving” y los genes del gusto en personas con obesidad
Authors: Marín-Soto María Delfina , Miliar-García Angel , Gómez-López Modesto , González-Mundo Ilicia , Aguilera-Sosa Víctor Ricardo
Published: June 2021

El “food craving” (FC) es un deseo incontrolable por ingerir alimentos en específico, se activa durante la fase de abstinencia de alimentos azucarados, salados y grasos. Se ha encontrado que se relaciona con obesi-dad (OB) y con trastornos del comportamiento de la alimentación, además de ser un factor negativo para la adherencia al tratamiento de la OB. Los Food Cravings Questionnaires Trait (T-rasgo) y State (S-estado) son instrumentos validados, que miden rasgo-estado, son confiables, y con consistencia interna alta (ɑ>0,90). El objetivo de esta investigación fue analizar diferencias entre sujetos normopeso (NP) y OB, en puntajes del FCQ Trait y State, y en la expre-sión génica de DRD2, TAS1R2, TAS1R3 y el TAS2R43. Se trató de un estudio correlacional, transversal de casos y controles, muestreo no probabilístico, y a conveniencia; con 20 sujetos NP y 20 sujetos OB, de ambos sexos entre 18-45 años, residentes de la Ciudad de México y del Estado de México. Se evaluaron el IMC, el FC y la expresión génica. Se encontraron diferencias significativas (p<0,05) en expresión relativa del TAS1R2, y correlación positiva entre el FCQ y expresión del TAS1R2 en OB; también se encontró que el FCQ-T y FCQ-S pre-dicen la expresión génica de TAS1R2 y TAS2R43 en hombres, y en mujeres del TAS1R2, TAS2R43 y el DRD2. Esta investigación ayuda a comprender la asocia-ción del FC, con el receptor del gusto dulce (TAS1R2), evidenciando el enlace con componentes moleculares, y su posible relación con adicción a alimentos azucarados.
Effect of vitamin D drops combined with conventional western medicine on children with Type 1 diabetes mellitus
Authors: Xue Jinjun , Xuan Jiacong
Published: June 2021

We investigated the therapeutic effect of vitamin D (VitD) drops, combined with conventional western medicine (insulin), on children with type 1 diabetes mellitus (T1DM). Eighty-four children with T1DM were divided into a routine group and an observation group (42 cases in each group). The routine group was treated with insulin; while the observation group was treated with insulin plus VitD drops. The serum levels of 25-hydroxyvitamin D3 (25(OH)D3) were compared between the two groups before and after treatment. The daily dosage of insulin, time needed for glucose control, two-hour postprandial blood sugar and frequency of episodes of hypoglycemia, were recorded. Flow cytometry was used to detect and compare interferon gamma (INF-γ), interleukin 4 (IL4), and INF-γ/IL-4 expression in CD4+ T cells of peripheral blood before and after treatment. Complication rates and readmission rates were documented during the six-month follow-ups. VitD drops significantly improved serum vitamin D levels in the routine group (P<0.05). Compared with this group, the daily doses of insulin were lower, the time of blood sugar reaching normal ranges was shorter and the frequency of hypoglycemia was lower in the observation group (P<0.05). There were significant differences in the 2-hour postprandial blood sugar levels, and flow cytometry results between the two groups (P<0.05). VitD drops combined with insulin are beneficial for blood glucose control of children with T1DM, effectively reducing the insulin utilization rate, reducing the frequency of hypoglycemia, and helping to regulate the Th1/Th2 balance disorder. Complementary treatment with this vitamin is safe and reliable, and can reduce the incidence of complications and readmission rates.
Simplified the Product Purchasing Ecommerce - Steelkart
Authors: Kumar Ahijeet
Published: June 2021

Since 1992, economic improvements took place drastically to integrate with the global economy of the world. It made easier, the foreign trade easier. E-commerce is the chunk of IT revolution and has become popular in trading specially in India. With the advancement of time various changes in the business and their transactions. India being an adapter of fast changing technology gives rise to the enhancement of e-commerce. In the view of this paper tries to present a view of evolution of ecommerce and especially in India. This paper shows the order, categories and organization evolved through e-commerce in both finance and physical expression. To extract the benefits obtained from e-commerce and to develop a platform for e-commerce in India. The government should also provide a legal platform for international trade and e-commerce and allow companies to expand globally with the taken care of basic rights like privacy, intellectual property rights, fraud prevention etc. This paper deals with the problem which is in the front of common manufacturers of transformers. Aim of this paper is the ways through which we can provide raw material to develop the transformer. So that these transformer producers get an ample amount of foreign raw products which help in improving the quality of product as well as reducing the cost. The Indian components of transformers do not perform so well in the terms of quality so Indian transformers lack in quality by using these foreign raw products transformer producer may produce the quality products and can also export to other countries
Experimental Study on Strength Parameters of Roofing Tiles Incorpating Pumice Powder
Authors: S. J Numair Abdul Musawwir
Published: June 2021

Our experimental investigation is being carried out to find out an alternative for tiles made from terracotta, because these tiles get easily cracked having less in strength. This drawback is likely motivated to conduct investigation to deliver the product by not this limitation. So, we have implemented work by using material called ‘pumice’. Naturally it will absorb the heat and emit cooling to the atmosphere. At early stage pumice powder were added in the range 2.5%, 5%, and 7.5%. Conventionally available materials do not offer acceptable solutions. Prices of corrugated G.I. sheets are continuously escalating, and their use in not preferred because of thermal discomfort. Use of cement sheets is not recommended because of health hazards associated with asbestos. In India there is an acute shortage of locally available cheap roofing materials. Home-builders particularly the poor, are in dire need of cost-effective materials to build their homes with. In addition, mass rural housing programmers supported by Central and State Governments are increasingly looking at low-cost building techniques.
Solar Chimney Power Plant - A Review on Latest Technological Advances for Performance Enhancement
Authors: Arun Sreelekha
Published: June 2021

The energy consumption on global scale is continuously increasing, resulting in rapid use of energy resources available. Solar chimney power generation technology hence began to get growing attention as its basic model needs no depleting resources like fossil fuels for its functioning but only uses sunlight and air as a medium. It takes the advantage of the chimney effect and the temperature difference in the collector that produces negative pressure to cause the airflow in the system, converting solar energy into mechanical energy in order to drive the air turbine generator situated at the base of the chimney. Solar Chimney Power Plant (SCPP) brings together the solar thermal technology, thermal storage technology, chimney technology and air turbine power generation technology. However, studies have shown that even if the chimney is as high as 1000 m, the efficiency achievable is only around 3%. Hence, this review paper intents to put together the new technological advancement that aims to improve the efficiency of SCPP.
Treatment of Alkaline Water using Reverse Osmosis System with the Help of Renewable Solar Energy
Authors: Dhinakaran S.
Published: June 2021

The aim of this project is to develop a low-cost water purification system that provides clean drinking water. The project has a broad reach since drinking water pollution is a big global problem. This device would provide a solution to contaminated drinking water. Electric current is used to power the purifier during the water treatment process, reducing fluoride, chloride, and increasing the pH content of salty water, resulting in potable drinking water. To achieve this aim, a project management plan has been devised that divides the tasks amongst the community. The ultimate goal of designing this project is to provide clean drinking water at a low cost. The aim of this project is to develop and build a small-scale water purification system that needs little maintenance and is inexpensive. Initially, solar power would be used to power the purification system and to transition the system to renewable energy.
Modeling and Simulation of Heat Pump Air-Conditioning System using Ecofriendly Refrigerants
Authors: Landage Ajay
Published: June 2021

A simulation approach to heat pump systems is proposed in this paper. The evaluation of working fluids is conducted. Moreover, the selected refrigerants are used in the simulation. Subsequently, the system is analyzed in terms of the coefficient of performance (COP) and energy efficiency. Some alternative refrigerants, instead of R22 used R290 refrigerent. It is described the selection of refrigerants adapted to each utilization, based on the thermodynamic and -physical properties, the technological behaviour, costs and use constraints as principal aspects of the environmental protection. Also, it is performed a comparative analysis in function of the total equivalent warming impact (TEWI) for some possible substitutes of refrigerant R22 used in various refrigeration and heat pump systems.
Solar-Wind Hybrid Power Generation with Smart Grid Interconnecting System
Authors: Gautam Rahul
Published: June 2021

As we know the demand of electricity is increased day by day which cannot be fulfill by non-renewable energy source. So we use renewable energy source to fulfill the demand of electricity. The main objective of this research paper is study various aspect of performance of hybrid power generation system.[1] Voltage and frequency fluctuation and harmonies are major power quality issues in smart grid interconnected hybrid solar and wind power system. To overcome this issues we use Flexible alternating current transmission system (FACTS).The application of FACTS devices has been playing an important role in improving the flexibility, stability of smart grid.[3].
IOT Based Smart City Management
Authors: Bhalerao Prof. Chaitali
Published: June 2021

In the present field technologies like automation, power consumption, and cost-effectiveness should be mainly considered. To reduce manpower with the help of intelligent systems automation was intended. The utilization of inexhaustible wellsprings of energy is significant in light of the fact that wellsprings of energy are restricted though energy utilization has increments. By utilizing the renewable power, it can encourage the high power demand. The main aim of this project is to describe a method of modifying the street light and smart irrigation system controller. The massive deployment of the internet of things is allowing Smart city projects and initiatives all over the world. The IoT is a modular approach to merge various sensors with all ICT solutions. With over 50 billion objects will be connected and deployed in smart cities operation is the IoT communications. IoT is designed to support the Smart city concept, which aims at utilizing the most advanced communication technologies to promote services administration of the city and the citizens. Blynk android app is used to display the sensor readings.
Solar Powered Mobile Operated Farmer Friendly Multifunction Agribot
Authors: Katre Nilesh
Published: June 2021

Many advances in technology have made agribusiness very labour intensive to be a part of the industry. As we spoke only 50 years ago, farmers began to incorporate methods into their farming practices. Those involved in the agricultural industry are said to be less likely to change. They were very firm in the ways that came before them. Now when we examine the agricultural industry, we can see that it is changing rapidly. Farmers are looking for new ways to implement technology to reduce costs and reduce working hours. Farmers have come up with an autonomous robot as a way to explore new technology in agriculture. Solar-powered mobile-powered robots are new to the agricultural industry, but are rapidly gaining popularity from agricultural research institutes across the United States. These tractors are described by Farm Industry News as a tractor that drives its solution with a computer under control. Despite being in the research stage of development, autonomous robots are becoming more of an idea than a reality. When the robot is moving on the surface, it is controlled by a Bluetooth technology based mobile remote
Effect of nutrition education with the principles of Diabetes Self-Management Education (DSME) on knowledge and physical activity of type 2 diabetes patients
Authors: Khansa Raden Rizqia
Published: June 2021

Diabetes mellitus (DM) is one of the most critical illnesses experienced worldwide. Pillars for the management of type 2 DM are education, medical nutrition therapy, physical exercise, and pharmacological interventions. This study aimed to analyze Diabetes Self-Management Research (DSME) on the level of knowledge and activities of type II DM patients in Fatmawati General Hospital, South Jakarta. This research method used pre-experimentation with one group pretest-posttest. Analysis of the data used in univariate and bivariate analysis with a paired t-test. Sampling method was using a consecutive sampling technique obtained by 23 subjects. The results of the study showed differences between the previous and conducted DSME on the level of knowledge (p<0.001) and the level of physical activity (p=0.001). Based on the results of this study, there needs to be an improvement in the curriculum with support materials related to stress and the healthcare system.
The factors associated with cardiorespiratory fitness status of students at Muhammadiyah 3 Senior High School Jakarta
Authors: Nisa Najran , Fitriani Anna
Published: June 2021

The status of cardiorespiratory fitness is an indicator of importance in measuring a person’s fitness. The status of fitness cardiorespiratory is the ability of a person in supplying the heart and lungs, spreading and using oxygen is influenced by several factors such as gender, intake of nutrients, and nutritional status. This research aimed to determine the factors related to the status of cardiorespiratory fitness of students at Muhammadiyah 3 Senior High School, Jakarta. Variables were sex, nutritional status (IMT/U), energy and macronutrient intake (carbohydrates, protein, fat), and micronutrients (zinc, iron, calcium, vitamin C) intake. This is a cross-sectional study, with 85 subjects. Data were analyzed using the Spearman Correlation test and Chi-Square test. Retrieval of cardiorespiratory fitness status data was measured by means of 20-meter shuttle run in a bleep test. The study showed that the majority of subjects were male. Most of subjects had less energy, carbohydrates, protein, fat, calcium, vitamin C, zinc, and iron. The statistical test showed that there were relationship between sex and nutritional status of IMT/U with the status of cardiorespiratory fitness (VO2max). There was no correlation between energy, carbohydrates, protein, fat, vitamin C, zinc, calcium, and iron intake with the status of cardiorespiratory fitness.
The effectiveness of nutrition education on mother's knowledge and the pattern of infant and child feeding in Kapetakan District, Cirebon Regency, West Java
Authors: Choliyah Pipit
Published: June 2021

Feeding infants and toddlers (PMBA) is one of the government programs to reduce child mortality. PMBA include early breastfeeding initiation (IMD), exclusive breastfeeding, complementary food and breastfeeding up to 2 years old. The survey results in Pegagan Lor village, the case of malnutrition in Kapetakan sub-district was higher than national, which was 23%. The purpose of this study was to determine the effectiveness of providing nutrition education on maternal knowledge and feeding patterns of infants and toddlers. This research type was quasi-experimental with a control group pre-test and post-test design. The sample of this research is 70 mothers of toddlers who have children aged 6 to 24 months. The inclusion criteria in this study were mothers of toddlers who could read and write, and were willing to be respondent. The sample was divided into two groups of intervention and control group. In the intervention group was given nutrition education and booklets, while in the control group was only booklet. Data processing on knowledge variable used the paired sample t-test, and the feeding infants and toddlers pattern used the Wilcoxon sign test. Based on the results of the research that has been carried out, it can be concluded that the provision of nutrition education and booklet was more effective in changing knowledge and patterns of giving feeding infants and toddlers compared to only providing booklet. Providing nutrition education and booklets can provide changes in the direction of better maternal knowledge and feeding infants and toddlers pattern.
Analisis Kualitatif dan Kuantitatif Kandungan Boraks Pada Bakso Tusuk di Wilayah Kabupaten Gunungkidul Provinsi Daerah Istimewa Yogyakarta
Authors: Harimurti Sabtanti , Setiyawan Asep
Published: June 2021

Makanan adalah salah satu sumber energi bagi tubuh manusia. Makanan yang baik adalah makanan yang memiliki tingkat gizi yang tinggi sehingga berpengaruh pada kualitas kesehatan manusia. Salah satu makanan yang sedang digemari dan sering ditambahkan zat berbahaya adalah bakso tusuk. Penelitian ini dilakukan untuk mengetahui seberapa lama bakso tusuk dapat dikonsumsi dan disimpan pada suhu ruang dan mengetahui ada tidaknya kandungan boraks pada bakso tusuk serta mengukur kadar boraks pada bakso tusuk di wilayah Kabupaten Gunungkidul, Provinsi Daerah Istimewa Yogyakarta. Jenis penelitian yang digunakan adalah deskriptif laboratorik dengan pemeriksaan laboratorium secara kualitatif dengan metode pembusukan, uji warna kertas tumerik dan nyala api sedangkan secara kuantitatif dengan metode titrasi asam basa. Teknik pengambilan sampel pada penelitian ini adalah cluster sampling. Hasil analisis kualitatif dan kuantitatif menunjukan seluruh sampel bakso tusuk di Kabupaten Gunungkidul Provinsi Daerah Istimewa Yogyakarta, positif mengandung boraks. Kadar boraks berkisar antara 0,34%–3,41%.