bluuebunny/crossref_metadata_2025 huggingface dataset:
AVALIAÇÃO DO USO E COBERTURA DO SOLO DA SUB-BACIA DO RIO ANAJÁ EM PAÇO DO LUMIAR - MA/BR
Authors: De Oliveira Borges Jordane , Santos Lago Willinielsen Jackeline
Published: July 2022

O presente estudo objetivou delimitar a área da Sub-bacia do Rio Anajá, analisando o uso e cobertura do solo com auxílio de geotecnologias livres através dos softwares Spring e QGIS. A metodologia aplicada consistiu no processamento de imagens a partir dos sistemas de informação geográfica (SIGs) referidos, onde para os mapas de drenagem foram utilizados a imagem do Landsat8, Carta DSG e imagem SRTM. Os dados temáticos de uso e cobertura da terra foram obtidos através da coleta de pontos por meio de GPS e interpretação visual das imagens após o processamento. Os resultados indicam que a sub-bacia do Rio Anajá, localizada na bacia do Rio Paciência, no município de Paço do Lumiar – MA, possui um canal de terceira ordem que nasce a uma altitude entre 50 e 60 m, no qual identificou-se 8 classes de uso e cobertura da terra. A adoção dos SIGs permitiu a delimitação automática da área da sub-bacia do Rio Anajá e quantificação das classes de uso e cobertura da terra, constatando que as áreas de construções urbanas e lavouras do tipo roça ocupam grande parte desta sub-bacia.
Proceder metodológico para la sistematización de resultados científicos sobre comprensión de textos
Authors: Ramos Negrín Mavis , Calzadilla Pérez Oscar Ovidio , Fragoso Ávila Juana Elena
Published: July 2022

La universidad actual tiene entre sus desafíos generar conocimiento científico mediante la sistematización de los resultados de investigaciones precedentes. En este contexto la sistematización en sí misma tiene el potencial de convertirse en un resultado científico nuevo basado en la resignificación, integración y perfeccionamiento de indagaciones precedentes. A los efectos de lo planteado el objetivo de este trabajo radica en: construir una experiencias basada en el estudio de sistematización de resultados científicos con los fundamentos teórico-didácticos sobre el tratamiento a la comprensión de textos en la asignatura Lengua Española del nivel Primario. esto condujo al empleo de métodos del nivel teórico: analítico-sintético, inductivo-deductivo, tránsito de lo abstracto a lo concreto, sistémico-estructural-funcional y la sistematización; y, del nivel empírico el análisis de documentos. Además, procedimientos matemáticos como la agrupación y registro de datos que enriquecieron el metaanálisis de los resultados sistematizados en la muestra. El principal valor científico del proceder metodológico como experiencia radica en transferir este modo peculiar de pensar y hacer en la formación del profesional en el actual proceso de validación del Plan de Estudio “E”.
Desarrollo de habilidades para la vida en estudiantes universitarios por medio de un programa de asignaturas electivas: un análisis de coincidencia de percepciones
Authors: García Sicard Nadia , Saldaña Medina Caleb , Salamanca Gómez Sophia , Jiménez Roa Daniel
Published: July 2022

El futuro del estudiantado depende de la medida en que este desarrolle las llamadas Habilidades para la Vida, especialmente aquellas relacionadas con el currículo académico. De ahí la importancia de evaluarlas. Este estudio explora el grado de coincidencia entre la percepción de profesores, monitores y estudiantes acerca de las habilidades para la vida, que se desarrollan en cuatro asignaturas electivas de la Universidad del Rosario, Colombia. Las percepciones se obtuvieron por medio de tres métodos de recolección: grupos focales, observación participativa y un cuestionario. Los resultados mostraron un porcentaje de coincidencia entre los y las participantes Sobre cuáles habilidades se desarrollaron, los resultados mostraron un porcentaje de coincidencia entre los y las participantes de 34,8% en la electiva de Enología, 55% en el Taller de Escritura Creativa, 80% en la electiva enfocada en el manejo del estrés y 94% en la electiva de Mapa de Sentidos; la coincidencia general fue de 66%. Al final se discute que, si bien es cierto las electivas están enfocadas de forma adecuada para conseguir una educación para la academia, también lo está para la vida. Es necesario establecer de forma previa y mesurable las habilidades a desarrollar en cada asignatura y de qué manera, con el fin de optimizar los resultados de aprendizaje y tener un impacto acorde a los objetivos de las asignaturas.

Los resultados mostraron un 66% de coincidencia entre los participantes llevando a la discusión de que, si bien es cierto que las electivas están enfocando de forma adecuada la educación para la vida y no únicamente para la academia, es necesario ajustar de forma previa y mesurable qué habilidades se desarrollan en cada asignatura y de qué manera, para optimizar los resultados de aprendizaje y tener un impacto acorde a los objetivos de las asignaturas.
Entablando diálogos con Freire: sobre el espacio pedagógico y otras reflexiones compartidas
Authors: Gutiérrez Slon Juan Antonio , Vargas Vargas Bryan
Published: July 2022

El ensayo hace énfasis en algunas reflexiones de Paulo Freire que se sustentan en el análisis de la “educación como práctica de la libertad” realizado a la luz de tres de sus obras: una teórica, una de aproximación empírica y otra de síntesis. Hace énfasis sobre la condición de opresión enmarcada en los procesos educativos a la vez que indaga sobre la perspectiva metodológica del espacio pedagógico y las posibilidades que éste tiene para superar la relación opresor-oprimido desde una propuesta de problematización desde voces sin discriminación incluidas en los procesos educativos del mundo sociopolítico.
Fundamentos para la elaboración de planes estratégicos
Authors: Sánchez Vargas Ludwin Alexander
Published: July 2022

Este libro propone una metodología para la elaboración de planes estratégicos como modelo que aporte a la gestión estratégica de empresas y organizaciones. Surge como resultado del proyecto de investigación Fortalecimiento de la gestión empresarial de mipymes de la cadena del cuero del municipio de Chocontá (Cundinamarca) realizado por él entre los años 2016 y 2018; proyecto que se desarrolló enmarcado en la línea de investigación Gestión organizacional definida por la Escuela de Ciencias Administrativas, Contables, Económicas y Administrativas de la Universidad Nacional Abierta y a Distancia -UNAD. Sobre todo porque desde la realidad de las empresas y las micro, pequeñas y medianas empresas estudiadas y la experiencia del autor se infiere la necesidad de las mipymes colombianas en cuanto a procesos de gestión estratégica. En el texto describe el paso a paso para la construcción de todos y cada uno de los componentes que debe tener un plan estratégico. También ilustra la metodología para la formulación de planes tácticos o funcionales y la elaboración del Balanced Scorecard -BSC o cuadro de mando integral -CMI como herramientas para la ejecución y el monitoreo de un plan estratégico. Su uso y aplicación contribuirá al logro de los objetivos corporativos que propicien la permanencia y el crecimiento de empresas y organizaciones de cualquier sector económico o industrial y de cualquier naturaleza (pública o privada) especialmente porque aporta a la gestión estratégica que haga frente a la dinámica del mundo altamente competitivo y cambiante de hoy.
Pregnancy outcomes in women with mechanical prosthetic heart valves: a retrospective case series analysis
Authors: Sceales Penny , Al-Sakini Nada , Mercaldi Rebecca , Odor Peter , Thomas Mari , Obrien Patrick , Bampoe Sohail , Walker Fiona
Published: July 2022

Introduction: Pregnant women with mechanical prosthetic heart valves
(MPHV) are reportedly at high risk of mortality and morbidity. We aimed
to compare outcomes at our specialist centre with national data, and
whether anticoagulation regimes influenced outcome. Methods: We
conducted a retrospective cross-sectional study of all pregnant women
with MPHV managed by our service between 2003-2021. Maternal and fetal
outcomes and anticoagulation data were collected. Summary statistics and
comparative analysis with results from the national UK-wide dataset were
compiled. Results: A total of 50 pregnancies in 23 women were
identified. Patients with complex valve replacements were common, with
34.8% of pregnancies involving management of dual MPHV. Maternal
mortality was zero (95% CI: 0-7.1). Serious maternal and obstetric
complications occurred in only 7 pregnancies (14.0%; 95% CI:
7.0-26.2%), including only two valve thromboses (4%). Live births
followed 31 of the pregnancies (62%), compared with a national baseline
of ~75%. Low molecular weight heparin was the most
commonly used anticoagulant during pregnancy (84%), but no single
anticoagulation regime was found to be universally optimal. Concomitant
low-dose aspirin was given to those with dual or systemic mechanical
atrioventricular valve replacement. Discussion: Our study is the largest
single centre report on maternal outcome for women with MPHV. We share
how comprehensive, multidisciplinary planning may significantly reduce
mortality and morbidity for our patients. Anticoagulation management
should be individualised according to patient risk profile. With
appropriate peripartum care, risk for women with MPHV considering
pregnancy may be lower than previously reported
Evolutionary origin and establishment of the diploid-tetraploid complex in Salix polyclona
Authors: He Li , Guo Fei-Yi , Cai Xin-Jie , Chen Hong-Pu , Lian Chunlan , Wang Yuan , Shang Ce , Zhang Yue , Wagner Natascha , Zhang Zhi-Xiang , Hörandl Elvira , Wang Xiao-Ru
Published: July 2022

Polyploids recurrently emerge in angiosperms, but most polyploids are
likely to go extinct before establishment due to minority cytotype
exclusion, which may be specifically a constraint for dioecious plants
to evolve polyploid populations. Investigations into the frequency and
distribution of polyploids in natural populations is thus necessary for
understanding polyploid evolution in plants. This study determined the
ploidy levels of 28 populations and 351 individuals of Salix polyclona,
and identified the type of polyploidy (auto- vs. allo-) using whole
genome re-sequencing data. We further investigated the phylogeny,
population genetic diversity and species range shifts to explore the
origin and spatiotemporal evolution of the polyploid complex. Our
analyses revealed a high frequency (52%) of autopolyploids in it with a
clear geographic distribution confined to the western part of its range
where complex mountain systems create higher levels of environmental
heterogeneity. Comparisons of diploid male and female genomes suggested
a female heterogametic sex-determining factor on chromosome 15, which
likely also acts in the dioecious polyploids. Fossil-calibrated
phylogeny showed a more recent diversification of the polyploids (ca.
2.3 Ma) than the diploid (ca. 6.2 Ma), and population demographic
histories largely corroborated the geological and climatic history of
the region. Our results suggest that climatic oscillations and uplift of
eastern Qinghai-Tibetan Plateau and the connecting mountains may have
facilitated the preservation and establishment of polyploid populations.
This study provides an example of the evolution of a diploid-polyploid
complex in a willow species and illustrates a role of polyploidization
in mountain biodiversity.
Depression, anxiety and resilience during COVID-19 in Dutch patients with Cystic Fibrosis or Primary Ciliary Dyskinesia and their caregivers
Authors: Noij Lieke , Haarman Eric , Hashimoto Simone , Terheggen-Lagro Suzanne , Altenburg Josje , Twisk Jos , Verkleij Marieke
Published: July 2022

Background. The COVID-19 pandemic has spread across the world,
leading to government measures associated with a negative impact on
mental health. The aim of this study was to evaluate the impact of
COVID-19 on depression, anxiety and resilience in Dutch people with
cystic fibrosis (PwCF) or primary ciliary dyskinesia (PwPCD) and their
caregivers during the pandemic. Methods. Adolescents (12-17
years), adults and caregivers of children (0-17 years) with CF or PCD
completed questionnaires on depression (PHQ-9), anxiety (GAD-7) and
resilience (BRS) between September 2020 and February 2021. The
psychosocial impact of COVID-19 was measured by the Exposure and Family
Impact Survey (CEFIS) Part 2. Mixed model analyses compared PHQ-9 and
GAD-7 results to participants’ pre-pandemic scores. Results. 110
participants (10 PwCF, 31 PwPCD, 52 CF caregivers, 17 PCD caregivers)
completed questionnaires during the pandemic. Pre-pandemic outcomes were
available for 87 participants. The prevalence of symptoms of depression
and anxiety (PHQ-9 or GAD-7 scores ≥5) in PwCF and PwPCD and their
caregivers before and during the pandemic was high, with an increase in
depression in PwCF (2.75; 95%-CI: 0.82 to 4.68) and increase in anxiety
in CF caregivers (1.03; 0.09 to 1.96) during the pandemic. Resilience
was within the normal range for all groups, CEFIS scores corresponded to
a low to normal impact. Conclusion. PwCF and PwPCD and their
caregivers were at high risk of increased depression and anxiety
symptoms both before and during the pandemic, which emphasizes the
importance of mental health screening and psychological care in CF and
PCD.
Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a reduced risk of unfavorable COVID-19 course compared to their non-prescribed peers: a nationwide matched cohort study
Authors: Trkulja Vladimir , Kodvanj Ivan
Published: July 2022

Aim. To assess the relationship between a fact of being prescribed
fluvoxamine around the time of COVID-19 diagnosis and subsequent
hospitalizations and mortality in COVID-19 outpatients. Methods. Using
administrative data, we identified adult COVID-19 outpatients diagnosed
up to August 15, 2021 in Croatia. Subjects prescribed fluvoxamine around
the time of COVID-19 diagnosis (Group A), their peers suffering similar
psychiatric difficulties but not prescribed with fluvoxamine (Group B)
and those free of psychiatric difficulties/treatments (Group C) were
mutually exactly matched on a range of pre-COVID covariates. We
determined relative risks of COVID-19-related hospitalization, 30-day
all-cause hospitaliziation and of COVID-19-related mortality. Results.
Out of 416030 outpatients, 1016 were Group A subjects, 749 of whom were
matched to 31336/95984 Group B subjects, while 866 were matched to
22792/275804 Group C subjects. Group B and C patients were matched 82323
to 268778. Matched A vs. B relative risks (95%CI/CrI), frequentist and
Bayes with skeptical, otpimistic and pesimistic priors, were:
COVID-related hospitalization 1.73 (0.56-3.33), 1.15 (0.55-2.11), 1.03
(0.56.1.96) and 1.43 (0.63-2.94), respectively; 30-day all-cause
hospitalization 1.88 (0.76-4.67), 1.76 (1.39-2.25), 1.76 (1.39-2.24) and
1.86 (1.43-2.38), respectively; COVID-19 related mortality 0.73
(0.35-1.55), 0.93 (0.53-1.76), 0.79 (0.40-1.54) and 0.88 (0.37-2.11),
respectively. Conslusion. COVID-19 outpatients prescribed fluvoxamine
around the time of COVID-19 diagnosis were not at a reduced risk of
subsequent hospitalizations and mortality compared to COVID-19
outpatients suffering similar psychiatric difficulties but not
prescribed with fluvoxamine, or compared to COVID-19 outpatients free of
psychiatric difficulties and related treatments
Blocking effect of Guan-Fu Base A on human Na V 1.5 channels and the mutants expressed in Xenopus Laevis oocytes
Authors: Wang Na , Fan Xin-Rong , Wen Jing , Zeng Bo , Chen Gui-Lan
Published: July 2022

Introduction GFA (Guan-Fu Base A) as one of the main active
substances in the Chinese medicine Ranunculaceae Aconite, has been
approved the effect of anti-atrial fibrillation via its atrial-selective
Na channel-blocking action. It is recently
undergoing phase IV clinical study. However, the molecular mechanism of
Na 1.5 channel inhibition by GFA is largely unclear.
Methods and Results Na 1.5 channel and its
mutants were expressed in Xenopus oocytes and the currents were
recorded with two-microelectrode voltage-clamp. GFA inhibited Na
1.5 currents in a concentration-dependent manner, with
IC of 66.24 μM, 371.59 μM, and 381.08 μM for
wild type (WT), Delta KPQ (∆KPQ) and R1623Q constructs, respectively.
Both the mutations of ∆KPQ and R1623Q decreased inhibitory potency of
GFA about 5~6-fold. N406K mutation significantly altered
the inhibition effect of GFA. Even 1 mM GFA has almost no inhibitory
effect on the mutant. For both the WT and mutant channels, GFA reduced
the currents in concentration, voltage and time dependent manner.
Conclusion: GFA is a potent blocker of Na 1.5
channel. N406, the aromatic residues in the transmembrane helical of
DIS6, is most likely responsible for the high-affinity binding of GFA to
Na 1.5 channel.
Exploring cultural values and sustainability preferences in housing development: A structural equation modeling approach
Authors: AULE Thomas Terna , MAJID Roshida Binti Abdul , JUSAN Mahmud Bin Moh’d
Published: July 2022

The study aimed to establish the relationship between values and people’s preferences for sustainable improvement in Nigeria’s indigenous housing context. The relationship was tested in SEM using ordinal survey data obtained between February and March 2022 with 241 valid samples. The mainstream values were statistically validated using CFA while the relationships were generated in the SEM. Results established a significant relationship between values and the people’s preferences for transformative improvements. The findings provide a foundation for long-term policy formation, practical transformative experimentation, and an empirical foundation for future methodological research.
Społeczno-ekonomiczne uwarunkowania rozwoju działalności agroturystycznej
Authors: Zawadka Jan
Published: July 2022

Celem pracy było przedstawienie motywów podejmowania działalności agroturystycznej, źródeł finansowania, wielkości oraz poziomu zwrotu wydatków poniesionych na rozpoczęcie przedsięwzięć związanych ze świadczeniem usług agroturystycznych. Badania przeprowadzono wśród 81 właścicieli gospodarstw agroturystycznych świadczących swoje usługi na terenie Lubelszczyzny. Metodą badawczą był sondaż diagnostyczny. Z przeprowadzonych badań wynika, że dominującym motywem podejmowania działalności agroturystycznej była chęć uzyskania dodatkowego dochodu. Kwaterodawcy wydatki związane z rozpoczęciem tej działalności pokrywali najczęściej z własnych oszczędności. Były one stosunkowo niewielkie – w ponad 90% przypadków poniżej 20 tys. zł. Jednak na ich zwrot trzeba było czekać minimalnie 2-3 lata.
Genetycznie modyfikowane uprawy jako potencjalne zagrożenie dla gospodarstw specjalizujących się w usługach ekoagroturystycznych
Authors: Żarski Tadeusz , Majchrzak Kinga , Żarska Henryka
Published: July 2022

Turystyka na obszarach wiejskich ma cały szereg form, z których najbardziej charakterystyczne są: turystyka wiejska, agroturystyka, i ekoagroturystyka. Ekoagroturystyka to specyficzna forma agroturystyki. Obejmuje ona bowiem pobyt w gospodarstwach ekologicznych. Gospodarstwa takie nie używają żadnych syntetycznych substancji chemicznych, nawozów, sztucznych barwników ani środków konserwujących w uprawie roślin i hodowli zwierząt. Ekologiczne produkty rolne podlegają ścisłemu nadzorowi i spełniają międzynarodowe standardy. Istotną cechą tej formy agroturystyki jest nie tylko pobyt w gospodarstwie rolniczym, ale także udział w pracy na roli oraz konsumpcja produktów z hodowli ekologicznej. Rolnictwo ekologiczne wyklucza całkowicie możliwość upraw i hodowli organizmów genetycznie modyfikowanych. Termin „organizm genetycznie modyfikowany” oznacza organizm, do którego genomu został wstawiony jeden lub więcej genów obcych tzw. transgenów zawierające sekwencje kodujące takie cechy jak odporność na herbicydy, lub związki owadobójcze. Inżynieria genetyczna tworzy organizmy, które nie mogłyby powstać w sposób naturalny. Jest to sprzeczne z zasadami rolnictwa konwencjonalnego, a przede wszystkim ekologicznego.
Dystrybucja usług agroturystycznych poprzez portal aukcyjny Allegro.pl
Authors: Sieczko Anna , Sieczko Leszek
Published: July 2022

W artykule podjęto próbę oszacowania wielkości podaży ofert noclegów w gospodarstwach agroturystycznych oraz ich regionalnego rozmieszczenia. Wyznaczono podstawowe statystyki cen oraz liczebności aukcji. Wykonano porównanie regionalnego rozmieszczenia ofert. W badaniach wykorzystano autorski programu w języku VBA pracujący w środowisku Excel.
BAF60a Deficiency in Macrophage Promotes Diet-Induced Obesity and Metabolic Inflammation
Authors: Kong Qin , Zou Jiahuan , Zhang Ziyin , Pan Ran , Zhang Zhe Yu , Han Shuang , Xu Yanyong , Gao Yue , Meng Zhuo-Xian
Published: July 2022

Adipose tissue macrophage (ATM) has been shown to play a key role in the pathogenesis of obesity-associated adipose tissue inflammation and metabolic diseases. However, the upstream factors that integrate the environmental signals to control ATM activation and adipose inflammation in obesity remain elusive. Here, we identify BAF60a, a subunit of the SWI/SNF chromatin remodeling complexes, as the central checkpoint regulator of obesity-induced ATM activation, adipose tissue inflammation and systemic metabolic impairment. BAF60a expression was robustly downregulated in the adipose tissue stromal vascular fractions (SVFs) in type 2 diabetic mice. Myeloid-specific BAF60a ablation (BaMKO) promotes ATM pro-inflammatory activation, exacerbating diet-induced obesity, insulin resistance and metabolic dysfunction. Conversely, myeloid-specific overexpression of BAF60a in mice attenuates macrophage pro-inflammatory activation. Mechanistically, transcriptome and chromatin landscape analyses demonstrate that BAF60a inactivation triggers the expression of pro-inflammatory gene program through chromatin remodeling. Moreover, motif analysis of ATAC-Seq and CUT&Tag-Seq data identifies the transcription factor Atf3 that physically interacts with BAF60a to suppress the pro-inflammatory gene expression, thereby controlling ATM activation and metabolic inflammation in obesity. Consistently, myeloid-specific Atf3 deficiency also promotes the pro-inflammatory activation of macrophage. Together, this work uncovers BAF60a/Atf3 axis as the key regulator in obesity-associated ATM activation, adipose tissue inflammation and metabolic diseases.
PATAS, a first-in-class therapeutic peptide biologic, improves whole-body insulin resistance and associated comorbidities in vivo
Authors: Schreyer Edwige , Obringer Cathy , Messaddeq Nadia , Kieffer Bruno , Zimmet Paul , Fleming Alexander , Geberhiwot Tarekegn , Marion Vincent
Published: July 2022

  

Adipose tissue is a key regulator of whole-body metabolic fitness because of its role in controlling insulin sensitivity. Obesity is associated with hypertrophic adipocytes with impaired glucose absorption; a phenomenon existing in the ultra-rare monogenic disorder Alström syndrome consisting of severe insulin resistance. Inactivation of ALMS1 directly inhibits insulin-mediated glucose absorption in the white adipose tissue and induces severe insulin resistance, which leads to type 2 diabetes, accelerated non-alcoholic liver disease and fibrosis. These phenotypes were reversed by specific adipocyte-ALMS1 reactivation in vivo. Subsequently, ALMS1 was found to bind to PKC alpha in the adipocyte and upon insulin signaling PKC alpha is released from ALMS1. Alpha helices in the kinase domain of PKC alpha were therefore screened to identify a peptide sequence that interfered with the ALMS1-PKC alpha protein interaction. When incubated with cultured human adipocytes, the stapled peptide termed PATAS, for Peptide derived of PKC Alpha Targeting AlmS, triggered insulin-independent glucose absorption, de novo lipogenesis and cellular glucose utilization. In vivo, PATAS reduced whole-body insulin resistance, improved glucose intolerance, fasting glucose, liver steatosis and fibrosis in rodents. Thus, PATAS represents a novel first-in-class peptide that targets the adipocyte to ameliorate insulin resistance and its associated comorbidities. 
BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation
Authors: Kong Qin , Zou Jiahuan , Zhang Ziyin , Pan Ran , Zhang Zhe Yu , Han Shuang , Xu Yanyong , Gao Yue , Meng Zhuo-Xian
Published: July 2022

  

Adipose tissue macrophage (ATM) has been shown to play a key role in the pathogenesis of obesity-associated adipose tissue inflammation and metabolic diseases. However, the upstream factors that integrate the environmental signals to control ATM activation and adipose inflammation in obesity remain elusive. Here, we identify BAF60a, a subunit of the SWI/SNF chromatin remodeling complexes, as the central checkpoint regulator of obesity-induced ATM activation, adipose tissue inflammation and systemic metabolic impairment. BAF60a expression was robustly downregulated in the adipose tissue stromal vascular fractions (SVFs) in type 2 diabetic mice. Myeloid-specific BAF60a ablation (BaMKO) promotes ATM pro-inflammatory activation, exacerbating diet-induced obesity, insulin resistance and metabolic dysfunction. Conversely, myeloid-specific overexpression of BAF60a in mice attenuates macrophage pro-inflammatory activation. Mechanistically, transcriptome and chromatin landscape analyses demonstrate that BAF60a inactivation triggers the expression of pro-inflammatory gene program through chromatin remodeling. Moreover, motif analysis of ATAC-Seq and CUT&Tag-Seq data identifies the transcription factor Atf3 that physically interacts with BAF60a to suppress the pro-inflammatory gene expression, thereby controlling ATM activation and metabolic inflammation in obesity. Consistently, myeloid-specific Atf3 deficiency also promotes the pro-inflammatory activation of macrophage. Together, this work uncovers BAF60a/Atf3 axis as the key regulator in obesity-associated ATM activation, adipose tissue inflammation and metabolic diseases.
Prediction of gestational diabetes mellitus in the first trimester: is it possible?
Authors: Hansu İnci , Hansu Kemal , Balık Zekeriya , Özdemir Halis , Yücel Neşe
Published: July 2022

Objective: The aim of this study is to identify the first trimester markers that may be associated with gestational diabetes mellitus (GDM) and to evaluate whether those markers might be used for prediction of gestational diabetes or not. Methods: Pregnant women between 11 and 14 weeks of gestation applying to the university hospital between August 2018 and March 2019 were included in the study. Body mass index calculation and blood tests including complete blood count, TSH, T3, T4, HbA1c, uric acid, CRP, procalcitonin, PAPP-A and b-hCG levels were done during assessment followed by 50 grams of glucose challenge test between the 24 and 28 weeks of gestation for each woman. Patients with positive results were further evaluated with a 3-hour, 100-g OGTT. According to the diagnostic test results, the relationship between biochemical markers during the first trimester, BMI and GDM was statistically analyzed. Results: A hundred and eighty-two pregnant women participated in the study. Fifty-four women had positive glucose challenge test (GCT) results while 128 women had negative results. Pregnant women with positive GCT results underwent 3-hour, 100-g OGTT and, 24 pregnant women were diagnosed with GDM, while 158 pregnant women were considered healthy according to the results. There was no statistically significant difference between GDM and non-GDM groups in terms of age, height, TSH, T3, T4, b-hCG-mom, PAPP-A, PAPP-A-mom, uric acid and procalcitonin (p>0.05). The mean body weight, body mass index and HbA1c levels were higher and b-hCG levels were lower in the GDM group compared to the non-GDM group, and these findings were statistically significant (p<0.001). Conclusion: The use of first trimester markers in GDM prediction seems to have no significance. There is a need for extensive, randomized studies with universal criteria.
The effect of COVID-19 infection on hematological parameters and early pregnancy loss
Authors: Atak Zeliha , Rahimli Ocakoğlu Sakine , Uyanıklar Özlem , Üstünyurt Emin
Published: July 2022

Objective: Based on the fact that Coronavirus Disease 2019 (COVID-19) is associated with many hemocytometric changes, we aimed to investigate the effect of this underlying inflammatory process on the frequency of early pregnancy loss (EPL) in this clinical trial. Methods: This is a retrospective cohort study. The patients with laboratory-confirmed COVID-19 infection before the 20 weeks of gestation were determined as the study group. Healthy pregnant women in their early pregnancy were determined as the control group. Hematological parameters of all patients included in the analysis were evaluated. Results: A total of 176 pregnant women with confirmed COVID-19 infections were evaluated, of which 117 were included in the analysis. One hundred and seventeen healthy pregnant women were determined as the control group. There was no difference between the groups according to demographic characteristics. The median white blood cell (WBC) and lymphocyte levels were lower in patients with COVID-19 infection (p<0.001 and p<0.001, respectively). The value of platelet/lymphocyte ratio (PLR) was higher in the group with COVID-19 infection (160.95 vs. 132.42, p<0.001). It was also determined that the median plateletcrit level was lower in the group with COVID-19 infection (p<0.001). The rate of EPL in the COVID-19 infection group and control group was 14.2% and 9.4%, respectively (p=0.220). Conclusion: COVID-19 infection presents with low lymphocyte count and plateletcrit values in pregnant women, and an increase in PLR rates in relation to the severity of the disease is observed. Although not statistically significant, COVID-19 infection was associated with increased EPL rates in our study.
PENGARUH KEPEMILIKAN KELUARGA TERHADAP KEBIJAKAN DIVIDEN (STUDI EMPIRIS PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2016-2018)
Authors: Siswantaya I Gede
Published: July 2022

ABSTRACTThis research aims to examine the effect of family ownership on dividend policy, since in Indonesia most companies are family companies. The sample of this research is banking companies which published annual reports in the period of 2016-2018. In all, there are 29 companies and 87 observations. This research uses the data derived from the Indonesia Stock Exhange official website (www.idx.co.id). Hypothesis is tested by using multiple regression analysis, with Return on Assets (ROA) as the control variable. The results show that family ownership negatively affects dividend policy.Keywords: family ownership; dividend policy; return on assets; expropriationABSTRAKPenelitian ini bertujuan untuk menguji pengaruh perusahaan dengan kepemilikan keluarga atas kebijakan dividen yang akan diambil, hal tersebut dikarenakan Indonesia merupakan salah satu negara yang karakteristik perusahaannya merupakan perusahaan kepemilikan keluarga. Sampel dalam penelitian ini adalah perusahaan perbankan yang menerbitkan laporan tahunan 2016-2018. Berdasarkan kriteria yang ditetapkan, terdapat sampel 29 perusahaan perbankan dengan 87 pengamatan. Data penelitian diambil dari website resmi Bursa Efek Indonesia (www.idx.co.id). Pengujian hipotesis menggunakan analisis regresi linear berganda. Variabel kontrol yang digunakan dalam penelitian ini adalah Return on Assets (ROA). Hasil dari penelitian ini menunjukkan bahwa kepemilikan keluarga berpengaruh negatif terhadap kebijakan dividen. Kata kunci: kepemilikan keluarga; kebijakan dividen; return on assets; ekspropriasi
The Case of an Online Hands-on Class based on Video Lecture Content
Authors:   The Korean Association of Practical Arts Education, Lee Eun-sang
Published: July 2022

The purpose of this study is to present the case of an online practice class applying video lecture content. For this purpose, the researcher designed a hands-on class on the topic of “making an electric car” for pre-service teachers. In order to produce video lecture content, various teaching and learning materials such as a website for teaching, demonstration videos, and class materials were prepared in advance. Based on these, a total of four video lectures were produced on the topics of “Introduction of theories related to electric car manufacturing activity,” “Electric car manufacturing process,” and “Solving engineering problems related to electric car activity.” The “modified CORDTRA analysis method” was used to examine the resulting video lecture content. The analysis result was presented as a CORDTRA diagram, which revealed the content covered by the video lectures. This study can be used as a precedent for assessing examples of online practice classes. In addition, the “modified CORDTRA analysis method” presented in this study can be utilized as a new method to analyze video lectures.
Analysis of Dietary Units in Practical Arts Textbook based on Subject Competencies and Skills in the 2015 Revised Practical Arts Curriculum
Authors:   The Korean Association of Practical Arts Education, Lee KyoungAe
Published: July 2022

In this study, in order to understand how much subject competencies and skills can be realized through the dietary unit in the Practical Arts textbook, the dietary units in the 5th and 6th grade Practical Arts textbook were analyzed based on the subject competencies and skills in the family life field of the 2015 revised Practical Arts curriculum. The conclusions drawn based on the results of this study are as follows.
First, all three subject competencies presented in the family life field of the Practical Arts curriculum could be cultivated by learning the dietary units in Practical Arts textbook based on the 2015 revised curriculum. In particular, it was found that life independence ability can be cultivated the most. As for the sub-elements of each subject competency, practical reasoning, decision-making, and critical thinking can mainly be cultivated in practical problem-solving ability. The ability to perform diet, clothing, and shelter, and healthy and safe living can mainly be cultivated in life independence ability. Family relationship and community consciousness, respect and communication with others, consideration and care/environmental and ecological consciousness can mainly be cultivated in relationship formation ability.
Second, among the skills presented in the 2015 revised Practical Arts curriculum, the skills that could be cultivated by learning the dietary units in the 5th and 6th grade Practical Arts textbook were most prominent in practicing(executing) and applying. Synthesizing, evaluating, exploring, and judging could also be cultivated by learning the dietary unit in Practical Arts textbook.
Third, most of the skills required to develop practical problem-solving ability can be cultivated in the dietary unit of Practical Arts textbook, so it can be said that the skills are relatively well connected for the cultivation of practical problem-solving ability. However, as for the life independence ability and the relationship formation ability, the skills required to cultivate these subject competencies were somewhat insufficient, so the link between the subject competency and the skills was found to be somewhat insufficient.
Perception of the Necessity on Contents of Invention Education of Elementary School Students
Authors:   The Korean Association of Practical Arts Education, Ryu Sanghee
Published: July 2022

The purpose of this study is to analyze the degree of necessity of invention education contents that perceived by elementary school students, the difference in perception of invention education contents according to general characteristics, and the correlation between the practical arts curriculum areas. The objects subjects of study were 350 students in the 5th and 6th grades from five elementary schools in Chungbuk. The data were analyzed using descriptive statistics, t-test, and correlation.
The research results are as follows. First, elementary school students' perception of the necessity of invention education contents contained in practical arts textbooks was slightly higher than intermediate average. Second, gender was not a significant variable affecting the perception of the necessity of invention education contents. However, grade and invention education experience were significant variables that had an effect. Third, it was found that there was a positive correlation between the practical arts curriculum areas containing invention curriculum contents.
According to the above research results, it can be seen that in order to improve perception of the necessity of invention education content, it is necessary to reflect the perception of students who are involved in education.
Industria en Jujuy (1973-2014). Quiebre del modelo sustitutivo, desindustrialización y especialización productiva
Authors: Bernasconi Mariana Soledad
Published: July 2022

La cuestión de la industrialización es un elemento de discusión necesario en la planificación del desarrollo de cualquier territorio, sobre todo teniendo en cuenta el rol protagónico que suele asignársele a la industria como motor de crecimiento y espacio conductor de un modelo de acumulación con inclusión social. No obstante, el papel que la industria desempeña en una economía, así como su estructuración al interior del sector, varía según el modelo de acumulación vigente e, incluso, puede llegar a presentar contradicciones en programas políticos que ponen a este bloque en el centro de sus estrategias. Por ello, en el presente trabajo se analiza el recorrido de la industria en Jujuy, en cuanto territorio rezagado en la senda de la industrialización, a lo largo de las últimas cuatro décadas (1973-2014), desde el quiebre del modelo de industrialización por sustitución de importaciones a partir del despliegue de las políticas neoliberales en el país, hasta el último período de crecimiento industrial en los años de la posconvertibilidad, todo ello en un espacio de articulación con el contexto económico nacional. Se pretende con esto evidenciar algunas continuidades y rupturas experimentadas en el sector manufacturero en este trayecto de largo plazo con base en el análisis de los censos económicos correspondientes. Quedará en evidencia la ausencia de un cambio estructural en la especialización productivo-industrial a lo largo del ciclo, con la respectiva inserción de la Argentina en la división internacional del trabajo y las ostensibles inequidades territoriales y regionales.
La política del ambiente en América Latina: Una aproximación desde el cambio ambiental global. Ciudad de México: Consejo Latinoamericano de Ciencias Sociales (CLACSO) y Universidad Autónoma Metropolitana, Unidad Xochimilco - División de Ciencias Sociales y Humanidades, 2017. Ma. Griselda Gunther y Ricardo A. Gutiérrez (Coord.)
Authors: Doloisio Brenda Natalia
Published: July 2022

Reseña del libro: La política del ambiente en América Latina: Una aproximación desde el cambio ambiental global. Ciudad de México: Consejo Latinoamericano de Ciencias Sociales (CLACSO) y Universidad Autónoma Metropolitana, Unidad Xochimilco - División de Ciencias Sociales y Humanidades, 2017. Ma. Griselda Gunther y Ricardo A. Gutiérrez (Coord.).
Trabajo y salud de los no docentes de la UNLP. Los riesgos psicosociales en el trabajo y su prevención. La Plata: Editorial de la Universidad Nacional de La Plata (EDULP), 2017. Julio César Neffa y Elena Denda
Authors: Flores Norma Beatríz
Published: July 2022

Reseña del libro: Trabajo y salud de los no docentes de la UNLP. Los riesgos psicosociales en el trabajo y su prevención. La Plata: Editorial de la Universidad Nacional de La Plata (EDULP), 2017. Julio César Neffa y Elena Denda.
Chávez Molina, E. y Muñiz Terra, L. (comps.). (2021). El desencuentro. Diferencias de clase en la Argentina desigual. Buenos Aires: Ediciones Imago Mundi
Authors: García Mailén
Published: July 2022

Revisión del libro El desencuentro. Diferencias de clase en la Argentina desigual por E. Chávez Molina y L. Muñiz Terra (comps.)
Eksplorasi Nilai Budaya Sipakatau Dalam Pelaksanaan Tugas Kepala Sekolah Pendidikan Dasar
Authors: Sumarni Sumarni , Abdullah Erviana , Nasir Muhammad
Published: July 2022

This study aims to describe the exploration of sipakatau cultural values in the implementation of the principal's duties at SD Negeri 205, Pammana, Wajo Regency, South Sulawesi. This study uses a qualitative approach. The location of this research is SD Negeri 205, Maroanging, Pammana, Pammana District, Wajo Regency, South Sulawesi Province. Data collection techniques through interviews, observation and documentation. Data analysis used descriptive analysis. The results of this study indicate that the exploration of sipakatau cultural values in the implementation of the duties of the principal at SD Negeri 205, Pammana, Wajo Regency, South Sulawesi has been reflected in the implementation of their daily duties, this can be seen from the attitude of the principal who has been able to respect and respect members school without having to look at the condition of the members and respect each other when meeting with members who are older and younger. In addition, the exploration of sipakatau cultural values has also been applied to tasks and functions related to (a) curriculum management; (b) student management, which consists of: student planning, student coaching, evaluation of student programs and activities, and student transfers; (c) management of school and community relations, which consists of: fostering relations with the external public and coaching with the internal public.
Desain Sistem Kerja yang Berpusat pada Manusia Transisi Ke Industri 4.0
Authors: Fandhilah Laisa Sofiana Nur , Giovanni Axel
Published: July 2022

Saat ini transisi Industri 4.0 semakin meningkat untuk menerapan perubahan dalam pekerjaan manusia dan kerja organisasi, sehingga menciptakan tantangan dan peluang baru. Untuk memanfaatkan dan menghadapi tantangan ini, perlu adanya pemahaman tentang interaksi dan penerapan rancangan sistem kerja yang berpusat pada manusia terhadap teknologi baru. Dalam artikel ini, menyajikan temuan tinjauan pustaka tentang gambaran sistem kerja yang berpusat pada manusia dalam menghadapi transisi Industri 4.0 . Kata Kunci :  Sistem kerja, Human-Centered, Industri 4.0
Pengaruh Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus Terhadap Belanja Modal
Authors: Ivana Diva , Hardiwinoto Hardiwinoto , Nurcahyono Nurcahyono
Published: July 2022

Penelitian ini bertujuan untuk menguji pengaruh pendapatan asli daerah, dana alokasi umum dan dana alokasi khusus terhadap belanja modal. Jenis penelitian ini adalah penelitian kuantitatif. Sampel pada penelitian ini diperoleh dengan menggunakan metode purposive sampling, yaitu pemilihan sampel dengan kriteria – kriteria yang telah ditentukan. Berdasarkan metode purposive sampling tersebut didapatkan sebanyak 80 sampel dari 35 kabupaten/kota provinsi Jawa Tengah dan 5 kabupaten/kota di DIY Yogyakarta. Teknik analisis yang digunakan adalah regresi linear berganda. Hasil analisis data diketahui pengujian hipotesis secara parsial PAD berpengaruh positif dan signifikan terhadap belanja modal, Dana Alokasi Umum berpengaruh tidak signifikan terhadap belanja modal, Dana Alokasi Khusus berpengaruh positif dan signifikan terhadap belanja modal. secara simultan PAD, DAU, DAK berpengaruh positif dan signifikan terhadap belanja modal. Kata Kunci : Pendapatan Asli Daerah, Dana Alokasi Umum, Belanja Modal
Revealing the Student Philanthropy Movement in the Midst of the COVID-19 Pandemic
Authors: Astutik Anita Puji , Khoirinindyah Safitri , Farihah Anis
Published: July 2022

The philanthropic movement aims to increase student knowledge and involvement in allocating funds to support social activism. At the time of the Covid-19 outbreak, philanthropy-based da'wah was a common form of da'wah carried out by students with the Muhammadiyah Covid-19 command center. This means that students and the Muhammadiyah Covid-19 Command Center "MCCC" were involved in dealing with the Covid-19 epidemic and have continued to do so. Using qualitative research, this study was conducted in 2020-2021 with the goal of describing and narrating the student philanthropy movement in the midst of the covid-19 pandemic. The data gathering method was "triangulation," which included observation, interviews, literature review, and documentation. Researchers used the approach of "persistent observation" to apply the data analysis process. The philanthropic movement seeks Muhammadiyah students' participation in propagating diverse da'wah material based on the philanthropic movement, which encompasses advocacy, donating, and service. During the extensive covid-19 pandemic, the surrounding community can learn about the charitable activity carried out by students in partnership with the Muhammadiyah Covid-19 Command Center. As a result, a network is developed to raise public awareness about COVID-19 and to assist in its management through the Philanthropy Movement. As a result, the Muhammadiyah student volunteers' movement in partnership with the Muhammadiyah Covid-19 Command Center is extremely forward-thinking. Social activities for Muhammadiyah students are easier in current times, therefore fundraising for areas affected by COVID-19 is quite advanced, and helping the community deal with calamities and individuals in need is very simple
Development of Jurisprudence Learning Media for Android-based Islamic Economics at SMK Muhammadiyah Karangmojo
Authors: Yarudin Yarudin , Arqam Mhd Lailan , Wantini Wantini , Perawironegoro Djamaluddin , Yusmaliana Desfa
Published: July 2022

The development of fiqh learning media for android-based Islamic economics at SMK Muhammadiyah Karangmojo was the focus of this research against the background that there were still many PAI learning methods, especially fiqh, using conventional methods. This study aims to describe the learning of fiqh in class XI at SMK Muhammadiyah Karangmojo and the development of fiqh media for android-based Islamic economics at SMK Muhammadiyah Karangmojo. This research applied the type of RD research with the Borg Gall model because it was expected to develop learning products. The research methods were model development, development procedures, and product testing. The model developed in this research was developing Islamic economics material based on Islamic Jurisprudence learning media. The results of this study indicate: (1) Fiqh learning class XI at SMK Muhammadiyah Karangmojo still uses conventional methods. There are still few teaching media for fiqh. There are 90% of students have android phones. Principals, teachers, and students expect innovation in learning media development. (2) Development of Android-based Islamic Economics Jurisprudence media. Media assessment in the form of material expert validation got a score of 73%, a fairly decent score, media experts got a score of 80% with a decent value, and the assessment of respondents in the small and medium stage usage test got a score of 90 with very good criteria to be used as class fiqh learning media XI SMK Muhammadiyah Karangmojo.