bluuebunny/crossref_metadata_2025 huggingface dataset:
РОЛЬ ПОЛІМОРФІЗМУ ГЕНІВ ЛЕПТИНУ ТА РЕЦЕПТОРА ДО ЛЕПТИНУ У РЕАЛІЗАЦІЇ МЕТАБОЛІЧНИХ ЕФЕКТІВ ОМЕГА-3 ПОЛІНЕНАСИЧЕНИХ ЖИРНИХ КИСЛОТ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ СХІДНОУКРАЇНСЬКОЇ ПОПУЛЯЦІЇ
Authors: Красова Наталія , Караченцев Юрій , Горшунська Мар'яна , Колеснікова Алла , Лещенко Жанна , Гладких Олександр , Воропай Тетяна , Романова Ірина , Полторак Вікторія
Published: December 2021

Відомо, що однонуклеотидні поліморфізми (ОНП) в генах адипокінів здатні впливати як на розвиток патологічних станів, пов’язаних з ожирінням, так і на ефективність застосованої фармакотерапії. Мета. Оцінити вплив поліморфних варіантів генів лептину LEP 2548G>A (rs7799039) та рецептора до лептину LEPR 223G>А (rs1137101) на терапевтичну ефективність омега-3 поліненасичених жирних кислот у хворих на цукровий діабет 2 типу східноукраїнської популяції. Матеріали та методи. 61 хворий на цукровий діабет (ЦД) 2 типу (ч/ж: 34/27, вік 53,4±1,4 років, тривалість захворювання 5,3±0,7 років, глікемія 9,1±0,4 ммоль/л; HbА1c 7,7±0,2%) з надлишковою масою тіла або ожирінням (індекс маси тіла 33,3±0,9 кг/м2) отримував додатково до стандартної пероральної цукрознижуючої терапії (сульфонілсечовина та/або метформін) щоденно протягом 3 місяців препарат омега-3 поліненасичених жирних кислот (ПНЖК) (460 мг ейкозапентаєнової кислоти + 380 мг докозагексаєнової кислоти). Контрольну групу складав 21 суб’єкт. Клініко-біохімічні параметри оцінювали до та після курсу лікування. Генотипування за ОНП LEP 2548G>A та LEPR 223G>А проводили за допомогою методу полімеразної ланцюгової реакції з використанням відповідних праймерів та ендонуклеаз (HhaI і MspI). Результати. Визначено, що хворі на ЦД 2 типу носії домінантного алеля G за ОНП 2548G>A гена лептину демонструють більшу ефективність омега-3 ПНЖК відносно зниження загальної інсулінорезистентності та інсулінорезистентності жирової тканини. Виявлено асоціацію рецесивного генотипу (АА) за поліморфізмом 223G>А гена рецептора лептину з більшою ефективністю омега-3 ПНЖК відносно зменшення інсулінорезистентності жирової тканини. Вивчені поліморфізми генів адипокінової ланки мають вплив на реалізацію терапевтичної гормонально-метаболічної ефективності препарату омега-3 ПНЖК за умов 3-місячного введення у пацієнтів з ЦД 2 типу та надлишковою масою тіла/ожирінням східноукраїнської популяції. Дані щодо поліморфного варіанту гена LEP та/або LEPR можуть бути використані в межах фармакогенетики як підґрунтя для персоналізованої профілактики та терапії з прогнозованим ефектом фармакологічного втручання.
THYROID FUNCTION OF RATS WITH EXPERIMENTAL AIT AT AN EARLY PERIOD AFTER THE INJECTION OF BIOPREPARATIONS OF CORD BLOOD
Authors: Kurylko Yuliia , Malova Nataliya , Sirotenko Larisa
Published: December 2021

The development of new methods for the treatment of autoimmune thyroid disease is an actual problem of endocrinology. The aim of research was studying of the cell-free effect biological product of cord blood with immunomodulatory properties "Cryocell-Cryocord " on rats’ thyroid function with AIT simulated at an early period of the study. Simulation of autoimmune thyroiditis was carried out by immunization with a suboperatively isolated human thyroid antigen in combination completing Freund's adjuvant on 30 adult male rats weighing 130 - 150 g. Correction was carried out by parenteral ingection of the "Cryocell-Cryocord". Hormonal research (determination of the content of thyroid hormones and antibodies to thyroglobulin (TG-AT) were effected by using standard test kits for enzyme-linked immunosorbent assay at early stages after exposure (7 days, 1 month). Statistical maintained of the results was carried out using the methods of variation statistics. It was used normal distribution to unpaired Student's test to compare indicators. The difference was considered significant at p<0.05. It has been shown the biological preparation of cord blood "Cryocell - Cryocord" has a positive effect with induced autoimmune thyroiditis. It has been noted the normalizing result of the effected correction on the thyroid function of animals in the early period of the studying. It has been proved after the introduction of the biological preparation "Cryocell - Cryocord" in animals with experimental autoimmune thyroiditis observed the inhibition of the manifestations of autoimmune aggression and the normalization of the functional activity of the thyroid gland. These investigations can be the foundation for the development of a new approach to the treatment of patients.
Development and uptake of the National Heart Foundation of Australia Smart Heart Guideline App (Preprint)
Authors: Atkins Brooke , Matthews Stacey , Walton Natalie , Mitchell Julie-Anne , Jennings Garry , Buttery Amanda
Published: December 2021

BACKGROUND

Implementation of clinical guidelines into routine practice remains highly variable. Strategies to increase guideline uptake include developing digital tools and mobile applications (apps) for real-time use in clinical practice. The National Heart Foundation of Australia publish three key cardiac clinical guidelines in collaboration with the Cardiac Society of Australia and New Zealand including: 1) the Australian clinical guidelines for the prevention and detection of atrial fibrillation; 2) the Australian clinical guidelines for the detection and management of heart failure ; and 3) the Australian clinical guidelines for the management of acute coronary syndromes. To improve access and uptake for healthcare providers we developed the Smart Heart Guideline App

OBJECTIVE

To understand the need for, develop and evaluate the uptake of an Australian-specific mobile app to improve access and uptake of three national cardiac clinical guidelines.

METHODS

We used an iterative mixed methods approach, an established method in mobile app development and evaluation. First, we conducted an online survey of end-users in 2017 to determine the need and acceptability of an Australian-specific mobile app to access cardiac clinical guidelines. Second, we engaged a software developer to create the Smart Heart Guidelines App using a process of design, testing and revision, which included user testing. The app was registered with the regulatory body in Australia, the Therapeutic Goods Administration, and made freely available from October 2019 on iOS and Android operating systems and promoted using multiple methods. Third, data from the app stores was analyzed between 1 October 2019 – 1 October 2020 to evaluate the app’s uptake and performance. Fourth, data from two annual national General Practitioner (GP) surveys in 2019 and 2020 were analyzed to assess awareness and use of the clinical guidelines and the app.

RESULTS

Most health professionals surveyed (89%; n=447/504) reported accessing resources electronically and most (70%) reported they would use an Australian-specific cardiac guidelines app. The app was downloaded 11 313 times (66%; n=7483 from Apple App Store; 34%; n=3,830 from Google Play) during the first 20-month period. Most downloads (84%; n=6300) were a result of searching for the app in the stores. Apple App Store data indicated over 59900 impressions (the number of times the app appeared in a search) and 9000 product page views (number of times a user viewed the apps product page). Monthly downloads rates varied. Many (85%) Android users deleted the app.

CONCLUSIONS

Health professionals supported the development of the Smart Heart Guidelines App. The number of app store searches and total downloads indicate initial promotion of the app was effective. Further evaluation of users’ experience is needed.
Поліфармація: визначення, ризики, менеджмент
Authors: Khaitovych M.V.
Published: December 2021

Проведено пошук у базах даних Scopus, Web of Science, MedLine, The Cochrane Library. Термін «поліфармація» на відміну від терміна «поліпрагмазія» не завжди має негативний відтінок, і його часто застосовують для позначення одночасного використання пацієнтом п’яти та більше лікарських засобів, а інтенсивною вважають поліфармацію у випадках, коли пацієнт одночасно вживає 10 і більше лікарських засобів. Однією з основних причин поліфармації є поліморбідність. Поліфармацію також можуть спричиняти тяжкий стан пацієнта, самолікування і невідповідні рекомендації, деякі демографічні фактори (вік, стать, рівень освіти), рівень розвитку системи охорони здоров’я. Поліфармація може бути відповідною (обґрунтованою), коли призначення великої кількості лікарських засобів виправдано, та невідповідною (проблемною), коли кількість призначених лікарських засобів неправильна та незбалансована. Проблемна поліфармація є проявом поліпрагмазії, при цьому кілька лікарських засобів призначають неналежним чином, що не дозволяє реалізувати передбачувану перевагу даних лікарських засобів, і ризик заподіяння шкоди від лікування перевищує користь внаслідок взаємодії лікарських засобів, виникнення побічних реакцій, збільшення економічного тягаря лікування. Особливо небезпечною є проблемна поліфармація для пацієнтів у тяжкому стані. Менеджмент проблемної поліфармації повинен базуватися на переведенні її у збалансовану форму. Обґрунтовується комбінація лікарських засобів, що дозволяє лікувати пацієнта ефективно, безпечно й економічно доцільно через попередження їх взаємодії та побічних ефектів. Як терапевтичне втручання може використовуватися відміна певних лікарських засобів, яку в кожного конкретного пацієнта потрібно здійснювати через оцінку переваг і ризиків. Для профілактики та корекції проблемної поліфармації в осіб похилого віку запропоновані критерії Beers, інструменти ARMOR, STOPP-START.
Невирішені питання класифікації захворювань пародонта (дискусія)
Authors: Biloklytska H.F. , Petrushanko T.O. , Chumakova Yu.H. , Kopchak O.V.
Published: December 2021

No abstract
Kerentanan Perempuan dalam Surveillance Capitalism
Authors: Lejo Bergita P. Pricelia
Published: December 2021

Tulisan ini bertujuan untuk menganalisa kerentanan perempuan terhadap Kekerasan Gender Berbasis Online (KGBO) di dalam ruang digital. Studi ini menggunakan konsep kapitalisme pengawasan/surveillance capitalism dan symbolic violence sebagai dasar untuk memahami logika ekonomi dan juga kekerasan yang berlangsung dalam ruang digital. Ruang digital sebagai alat ekonomi tidak hanya menghasilkan “behavioral surplus” sebagai material baru tetapi juga menjadi ruang bagi terbentuknya “dominant habitus” tentang siapa itu perempuan dan bagaimana seharusnya perempuan merepresentasikan dirinya. Dominant habitus yang senantiasa direproduksi mampu menciptakan kebutuhan ekonomi bagi perempuan melalui komodifikasi dan bahkan eksploitasi terhadap tubuh perempuan yang terepresentasi dalam teks gambar, dan video di dalam platform digital. Melalui proses-proses ini, perempuan mengalami kekerasan simbolik yang terus-menerus direproduksi dalam dominant habitus. Dengan demikian, bekerjanya surveillance capitalism dan menguatnya dominant habitus di dalamnya menjadi kondisi yang membuka ruang bagi berlangsungya KGBO terhadap perempuan. Dengan menggunakan perspektif kritis dalam memandang KGBO tulisan ini hendak mendalami proses-proses yang mengkondisikan kerentanan perempuan di dalam ranah digital. Pemahaman akan hal-hal tersebut menjadi basis penting untuk memikirkan secara tepat posisi perempuan di dalam ruang digital yang saat ini secara luas diterima sebagai condition sine qua non yang di dalamnya berbagai bentuk relasi berlangsung. Dengan demikian, tulisan ini memberikan pijakan dasar untuk mendorong dan merumuskan beberapa agenda perubahan.

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This paper aims to analyze women's vulnerability to Online-Based Gender Violence (KGBO) in the digital platform. This study uses the concept of surveillance capitalism and symbolic violence as a basis for understanding the economic logic and violence that takes place in today's digital platform. Digital platform as an economic tool not only produces a "behavioral surplus" as a new material, but also becomes a space for the formation of a "dominant habitus"; who is women are and how women should represent themselves. Dominant habitus which is always reproduced is able to create economic needs for women through commodification and even exploitation of women's bodies which are represented in text, images and videos on digital platforms. Throughout these processes, mostly women suffer from symbolic violence which persistently reproduced by the dominant habitus. It obviously reflects the vulnerability of woman as the victim of KGBO. By using a critical perspective in looking at KGBO, this paper intends to explore the process that put women’s vulnerability in the digital arena. Understanding of these matters becomes an important basis for thinking about the exact position of women in the digital space which is currently widely accepted as a condition sine qua non in which various forms of relations take place. Thus, this paper provides a basic basis for encouraging and formulating several agendas for change.
Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD
Authors: Nowak Kristen L. , Farmer-Bailey Heather , Wang Wei , You Zhiying , Steele Cortney , Cadnapaphornchai Melissa A. , Klawitter Jelena , Patel Nayana , George Diana , Jovanovich Anna , Soranno Danielle E. , Gitomer Berenice , Chonchol Michel
Published: December 2021

Background and objectives

Clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD), including evidence of vascular dysfunction, can begin in childhood. Curcumin is a polyphenol found in turmeric that reduces vascular dysfunction in rodent models and humans without ADPKD. It also slows kidney cystic progression in a murine model of ADPKD. We hypothesized that oral curcumin therapy would reduce vascular endothelial dysfunction and arterial stiffness in children/young adults with ADPKD.

Design, setting, participants, & measurements

In a randomized, placebo-controlled, double-blind trial, 68 children/young adults 6–25 years of age with ADPKD and eGFR>80 ml/min per 1.73 m2 were randomized to either curcumin supplementation (25 mg/kg body weight per day) or placebo administered in powder form for 12 months. The coprimary outcomes were brachial artery flow-mediated dilation and aortic pulse-wave velocity. We also assessed change in circulating/urine biomarkers of oxidative stress/inflammation and kidney growth (height-adjusted total kidney volume) by magnetic resonance imaging. In a subgroup of participants ≥18 years, vascular oxidative stress was measured as the change in brachial artery flow-mediated dilation following an acute infusion of ascorbic acid.

Results

Enrolled participants were 18±5 (mean ± SD) years, 54% were girls, baseline brachial artery flow-mediated dilation was 9.3±4.1% change, and baseline aortic pulse-wave velocity was 512±94 cm/s. Fifty-seven participants completed the trial. Neither coprimary end point changed with curcumin (estimated change [95% confidence interval] for brachial artery flow-mediated dilation [percentage change]: curcumin: 1.14; 95% confidence interval, −0.84 to 3.13; placebo: 0.33; 95% confidence interval, −1.34 to 2.00; estimated difference for change: 0.81; 95% confidence interval, −1.21 to 2.84; P=0.48; aortic pulse-wave velocity [centimeters per second]: curcumin: 0.6; 95% confidence interval, −25.7 to 26.9; placebo: 6.5; 95% confidence interval, −20.4 to 33.5; estimated difference for change: −5.9; 95% confidence interval, −35.8 to 24.0; P=0.67; intent to treat). There was no curcumin-specific reduction in vascular oxidative stress or changes in mechanistic biomarkers. Height-adjusted total kidney volume also did not change as compared with placebo.

Conclusions

Curcumin supplementation does not improve vascular function or slow kidney growth in children/young adults with ADPKD.

Clinical Trial registry name and registration number

Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD, NCT02494141.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_02_07_CJN08950621.mp3
CLINICAL EFFICACY AND SAFETY OF HERBAL MEDICINE THERAPY IN RECURRENT APHTHOUS STOMATITIS: A SYSTEMATIC REVIEW
Authors: HASANAH NOVIA TRI , HIDAYAT WAHYU
Published: December 2021

Recurrent aphthous stomatitis is the most common oral mucous ulcerative lesion with challenging treatment. Herbal medicine therapy can propose clinical efficacy and safety due to its large biological activities. The objective was to review the clinical efficacy and safety of herbal medicine therapy in terms of ulcer size, pain score, healing duration, and adverse effects in recurrent aphthous stomatitis. A systematic was conducted based on the PRISMA statement. The search was performed using four electronic databases, namely PubMed, Cochrane, Science Direct, and Google Scholar for articles published from 2016 until 2021 using specific keywords. The search was limited to randomized controlled trials (RCTs), in English, full text, and study in humans. The main outcome is expected to be ulcer size, pain score, healing duration, and adverse effects. Quality assessment of selected articles was conducted using the Quality Appraisal of Randomized Trials Checklist (Cochrane Risk of Bias tool). The methodology quality of studies was evaluated using the Cochrane Handbook for Systematic Review of Interventions and Rev Man software. Five articles were eligible for analysis. The population of the sample study ranged from 34-70 patients of 15-65 y old. The herbs used were Aloe vera (Aloe barbadensis Miller), curcumin (Curcuma longa), licorice (Glycyrrhiza glabra), tobacco (Nicotiana tabacum L.), and pomegranate (Punica granatum Linn.). This review showed that there is some evidence of the clinical efficacy and safety of herbal medicine therapy in improved outcomes of recurrent aphthous stomatitis treatment with minimum adverse effects.
INTERLEUKIN AS BIOMARKER OF RECURRENT APHTHOUS STOMATITIS (RAS): A SYSTEMATIC LITERATURE REVIEW
Authors: DAMAYANTI INDAH , NUR’AENY NANAN , WAHYUNI INDAH SUASANI
Published: December 2021

This review aimed to describe the interleukins and interleukin gene polymorphisms related to and recommended as a RAS biomarker. Articles were searched through PubMed, ScienceDirect, and Cochrane Library databases, using the keywords of “Interleukin” AND “Recurrent Aphthous Stomatitis”. The Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) was used, and the writing of this review refers to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. A total of 8 articles met the criteria and showed a low risk of bias assessment. The level of IL-2, IL-6, IL-8, and IL-18 in the acute clinical phase of RAS were higher than in the recovery phase, but IL-10 levels showed decreased. IL-2, IL-6, IL-10 gene polymorphisms were found to be more frequent in RAS patients compared to controls, while IL-12 gene polymorphisms were found to be less associated with RAS pathogenesis. Interleukins at the proteomic level that recommended as a pro-inflammatory biomarker are IL-2, IL-6, IL-8, IL-12, and IL-18, while an anti-inflammatory is IL-10. Only IL-2 can be recommended as a biomarker at the genomic level, as other interleukins still require more investigation.
A REVIEW: ANTI-CANCER NATURAL PRODUCT DRUG DELIVERY SYSTEM DOSAGE FORM AND EVALUATION
Authors: GUNTINA RIZKA KHOIRUNNISA , SOPYAN IYAN , ZUHROTUN ADE
Published: December 2021

A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.
TARGETED DRUG DELIVERY SYSTEM; NANOPARTICLE BASED COMBINATION OF CHITOSAN AND ALGINATE FOR CANCER THERAPY: A REVIEW
Authors: SURYANI ADE IRMA , WATHONI NASRUL , MUCHTARIDI MUCHTARIDI , JONI I. MADE
Published: December 2021

This review aimed to determine the potential of the combination of chitosan and alginate as a targeted drug carrier in cancer therapy. This article is based on the results of previous research journals collected from Google Scholar, Scopus, PubMed and Science Direct sites using the keywords chitosan, alginate, targeted drug delivery for cancer, nanoparticle chitosan alginate. With the inclusion criteria, only English-language journals, journals published in the last 10 y, related to chitosan and alginate-based formulations. Meanwhile, the exclusion criteria were journals on pharmacological properties and bioactivity, food and cosmetics. The combination of cationic chitosan and anionic alginate forming strong cross-links showed good mucoadhesive properties, higher resistance to low pH and high-efficiency encapsulation without showing any obvious cytotoxicity. Ch/Alg can overcome the shortcomings of the active substance, such as its rapid release process and the required active ingredient is lower than that required to enter the cancer target cells so as to minimize side effects of the drug by providing drug-induced release. in response to various stimuli that are well suited to the intended purpose, such as pH stimuli, redox gradients, light, temperature, and magnetism. It is shown that the combination of chitosan and alginate base has great potential in targeting cancer therapy by increasing its therapeutic effectiveness and selectivity.
PHOSPHORYLATION OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II (CAMKII) AND EXTRACELLULAR REGULATED KINASE (ERK) IN STRIATUM MEDIATE NICOTINE DEPENDENCE IN BALB/C MICE
Authors: WILAR GOFARANA , FUKUNAGA KOHJI
Published: December 2021

Objective: Nicotine is an active compound in tobacco and has a rewarding effect in the central nervous system (CNS), which may lead to dependence. Although nicotine dependence is elucidated by brain mechanisms, synaptic molecular substrates underlying the dependence remain unclear. We hypothesized that reward signaling is mediated by dopamine and glutamate receptors, in where calcium/calmodulin-dependent kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) may mediate the synaptic signaling of dependence.

Methods: To investigate the roles of both CaMKII and ERK on nicotine dependence were assessed by conditioned place preference (CPP) methods followed by dissection. One day after conditioning, preference scores were measured to evaluate nicotine dependence. Mice were sacrificed and their striatum were dissected out for immunoblotting analyses of CaMKII and ERK phosphorylation.

Results: Nicotine-induced conditioned place preference as a symptom of nicotine dependence. CaMKII and ERK phosphorylation in striatum significantly increased along with the development of nicotine dependence.

Conclusion: We should next apply pharmacological strategies to manipulate CaMKII and ERK signaling. In particular, disruption of reconsolidation by disrupting CaMKII and ERK signaling may propose an attractive therapeutic approach to inhibit nicotine dependence.
DECOCTION OF POMEGRANATE (PUNICA GRANATUM L.) PEEL AS AN ANTHELMINTIC AGAINST TAENIA SAGINATA
Authors: SAPTARINI NYI MEKAR , MUSTARICHIE RESMI
Published: December 2021

Objective: The purpose of this study was to investigate the anthelmintic activity of pomegranate (Punica granatum L.) peel decoction against Taenia saginata.

Methods: The in vitro assay was conducted by observing the motility of T. saginata, which is isolated from cattle’s gastrointestinal tract, in various concentrations of pomegranate peel decoction with albendazole as a positive control.

Results: The results showed that the anthelmintic activity was dependent on decoction concentration and the duration of contact between decoction and nematode. Decoction at moderate concentration causes paralysis, while high concentration causes death. The 75% and 100% pomegranate peel decoction started to cause death at 240 min and 150 min after contact with T. saginata.

Conclusion: It was concluded that pomegranate peel decoction has anthelmintic activity.
FORMULATION AND EVALUATION OF PEEL OFF GEL FACIAL MASK FROM ARABICA COFFEE FRUIT PEEL EXTRACT (COFFEA ARABICA L.)
Authors: TANJUNG YENNI PUSPITA , JULIANTI ANDI IKA , ISNAYANTI IRNI , R. AGUSTIN
Published: December 2021

Objective: The aim of this study was to obtain a peel off gel facial mask preparation from Arabica coffee fruit peel extract that meets the requirements and to determine the antioxidant activity of Arabica coffee fruit peel extract and peel off gel facial mask preparation from coffee fruit peel extract

Methods: In this study, three formulations of peel off gel facial mask were made with 3 variations in the concentration of coffee fruit peel extract, namely F1 (1%), F2 (2%), and F3 (3%). Furthermore, the preparation was evaluated for 28 d of storage at room temperature (25-30 °C) and cold temperature (8 °C) which included organoleptic, pH, spreading ability, homogeneity, viscosity, dry time, and antioxidant activity.

Results: The results of the evaluation showed that F1, F2, and F3 met the requirements which included organoleptic, pH, spreading ability, homogeneity, viscosity, and dry time. The antioxidant activity of the coffee fruit peel extract was very strong (IC50 17.36 µg/ml). The antioxidant activity in the peel off gel facial mask sample of formula F1 (IC50 75.63 µg/ml) and formula F2 (IC50 50.71 µg/ml) was strong, and for formula F3 was very strong (IC50 21.44 µg/ml).

Conclusion: All formulas met the evaluation requirements, arabica coffee fruit peel extract and peel of gel facial mask preparation (F3) have very strong antioxidant activity.
OPTIMIZATION OF DILTIAZEM HYDROCHLORIDE NANOPARTICLES FORMULA AND ITS RELEASE KINETICS EVALUATION
Authors: WINARTI LINA , SARI LUSIA OKTORA RUMA KUMALA , NURAHMANTO EKA DEDDY IRAWAN DWI , ROSYIDI VIDDY AGUSTIAN , AMELIANA LIDYA , BARIKAH KUNI ZU’ AIMAH , ANJARANI REGITA ARDIA
Published: December 2021

Objective: The purpose of this study was to determine the optimum formula of diltiazem HCl-loaded chitosan nanoparticles due to variations in the speed and duration of stirring and evaluating the release kinetics in vitro using DDSolver.

Methods: The method used to prepare nanoparticles is ionic gelation. The ionic gelation method involves an ionic cross-linking between cations on the backbone of chitosan and anion, such as sodium tripolyphosphate (Na TPP). 

Results: Stirring speed of 1200 rpm and stirring time of 2 h produce an optimum response. The optimum formula has an entrapment efficiency of 71.10%, a particle size of 110.2 nm, and a polydispersity index of 0.268. The dry powder of diltiazem HCl nanoparticles produced a drug loading of 66.14±1.71% and a yield of 34.07±0.73%. The FT-IR showed ionic interaction (cross-linking) between ammonium ions from chitosan and phosphate ions from Na TPP. Scanning electron microscopy (SEM) analysis showed a particle size of 150 µm, a spherical shape, and rough surface morphology. In vitro release profiles indicated prolonged release, which follows the Korsmeyer Peppas model. 

Conclusion: It can be concluded that increasing the speed and duration of stirring will improve drug entrapment and reduce the particles size variation. The dry nanoparticles release mechanism is by diffusion and matrix erosion.
MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES OF ACALYPHA INDICA L. PHYTOCHEMICAL CONSTITUENTS WITH CASPASE-3
Authors: FEBRINA ELLIN , ALAMHARI RYAN KHUNAM , ABDULAH RIZKY , LESTARI KERI , LEVITA JUTTI , SUPRATMAN UNANG
Published: December 2021

Objective: This study investigated the structure-based molecular interactions between phytochemical constituents of Acalypha indica L. and caspase-3.

Methods: Thirty-three phytochemical constituents of A. indica were screened against caspase-3. The X-ray crystal structure of human caspase-3 was retrieved from https://www.rcsb.org/structure/. The molecular interactions of the phytochemicals were studied using the AutoDock 4.2 software and followed by molecular dynamics (MD) simulations using the Amber18 software.

Results: From this study, 25 screened phytochemicals were found to have a better binding mode than the native ligand. Moreover, the binding stability of the top four hits evaluated by MD indicated that the hydrogen bonds in MD were quite different from the molecular docking results due to the massive receptor and ligand movement in the MD simulations. However, with the exception of stigmasterol, all ligands were able to stabilize the protein.

Conclusion: This study suggested that γ-sitosterol acetate, β-sitosterol acetate, and γ-sitosterol might be able to induce caspase-3, thereby activating apoptosis. These high-affinity compounds can bind to caspase-3 more efficiently and were able to stabilize the protein. Therefore, they have the potential to be used as lead compounds in the treatment of cancer.
Governança, nanotecnologia e a necessidade de capacitação da força de trabalho
Authors: Abel Arcuri Arline Sydneia , Marques Pontes Jorge , Alves Schmidt Jose Renato , Balbão Andrade Luís Renato , Torres Faria Viegas Maria de Fátima , Ramos Soares Pinto Valéria , Vieira Filho Antonio Gracias
Published: December 2021

Este artigo tem por objetivo evidenciar as contribuições do projeto “Impactos das nanotecnologias na saúde dos trabalhadores” desenvolvido pela Fundacentro, Brasil, entre 2006 e 2019, para a capacitação dos trabalhadores, tendo em vista uma governança participativa em nanotecnologia. Foram utilizados como indicadores destas contribuições a descrição das ações desenvolvidas e um levantamento de citações encontradas na internet sobre o projeto, especialmente as produzidas por sindicatos ou entidades de trabalhadores. Ao evidenciar as ações desenvolvidas e as referências feitas à estas ações na Internet e publicações sobre o tema é possível não só garantir a pertinência do projeto desenvolvido como também obter uma indicação consistente do alcance e difusão dos conhecimentos abordados.
Horizonte de la Inteligencia Artificial y Neurociencias
Authors: Rabadán Alejandra T.
Published: December 2021

La inteligencia artificial permite que los procesos cerebrales sean analizados como procesos computacionales. Presenta dos líneas inquietantes: el Proyecto Robot, llamado androide cuando es antropomórtico, y el Proyecto Cyborg. Los robos están destinados a tareas repetitivas, riesgosas o de precisión, en las que pueden superar las limitaciones humanas, no percibiéndose conflictos éticos aunque sí nuevos desafíos en la organización social. Respecto de los androides, más allá de sus capacidades, habrá que considerar los efectos que puedan ocurrir en el ser humano durante la interacción con la máquina, como el impacto de la mímica androide sobre la emoción y estado de ánimo. Los cyborgs son criaturas compuestas por elementos orgánicos y cibernéticos cuya finalidad es emular o mejorar las capacidades de la parte orgánica. No se reconoce conflicto en su empleo para rehabilitación o para suplir funciones alteradas o ausentes; aspectos negativos serían su uso para la manipulación. Otra aplicación del proyecto cyborg a considerar es el enhancement, término utilizado en la literatura anglosajona para definir el aumento de facultades neurocognitivas o sensoriales mediante la estimulación transcraneal o intracraneal. El conflicto neuroético surge porque el objetivo no es curar sino la perfectibilidad, o nuevas modalidades de percepción. Los profesionales de la salud deben actuar en un entorno nuevo y cambiante que trasciende las neurociencias y la salud pública. El progreso continúa; por lo que se debe informar a la sociedad, anticipar dilemas, y ofrecer espacios de reflexión para la toma de decisiones individuales y para la especie humana.
Conceitos técnicos para evitar a lesão das radiações ópticas na abordagem para a região mesial do lobo temporal
Authors: Isolan Gustavo Rassier , Rodrigues Eduardo Melo , Marques Victor Matheus Olaves , Marques Victor Matheus Olaves , Becker Lia Grub , Dini Leandro Infantini
Published: December 2021

Introdução: As radiações ópticas são feixes de substância branca que cruzam o lobo temporal e se dirigem para a região occipital. Existem diferentes vias de acesso que podem evitar sua lesão durante procedimentos neurocirúrgicos e que resultam em defeitos de campo visual. Objetivos: Correlacionar o curso das radiações ópticas com as abordagens microneurocirúrgicas principais ao lobo temporal mesial, usando a técnica de dissecção das fibras de substância branca de Kingler. Realizar uma revisão da literatura e aplicar os resultados de dissecações anatômicas. Métodos: Dez cérebros humanos foram dissecados, por meio da técnica de dissecação de fibras da substância branca de Kingler. Casos ilustrativos são mostrados para evidenciar a aplicabilidade de rotas neurocirúrgicas que evitam lesão das radiações ópticas. Resultados: As abordagens transilviana, subtemporal e infracerebelar transtentorial têm o potencial de evitar lesões das radiações ópticas para lesões localizadas na região temporal mesial. Conclusão: O planejamento cirúrgico que considera a relação das radiações ópticas com estruturas da substância branca é essencial para uma abordagem de ressecções cirúrgicas no lobo temporal mesial.
Neuroparacoccidioidomicose em mulher adulta jovem
Authors: Cabral Filipe Laurindo , Buffara Leonardo Trindade , Marques Nathan Kulkys , Haag Karine , Steclan Chelin Auswaldt , Della André Possamai , Nones Diogo Pasquali , Reimann Junior Oscar Nelson , Peres Gabriel Hoher , Oliveira Arlindo de , Oliveira Júnior Amaurí Batista de , Brito Leonard Rocha Fonseca de , Lang Michael Ricardo
Published: December 2021

Introdução: A paracoccidioidomicose é uma doença sistêmica causada por fungos do gênero Paraccocidioides spp., sendo a micose profunda mais predominante da América Latina. O envolvimento do sistema nervoso central ocorre em 10-27% dos casos e apresenta difícil diagnóstico, necessitando de exames complementares de imagem e histopatológicos para confirmação diagnóstica. Objetivo: Relatar caso raro de neuroparacoccidioidomicose, destacando os achados nos exames de imagem, anatomopatológico e tratamento. Metodologia: Paciente do sexo feminino, 30 anos, que após atendimento inicial, observação das manifestações clínicas e de neuroimagem, houve hipótese diagnóstica sugestiva de pseudotumor intracraniano. Todos os dados foram descritos e interpretados com base nas informações contidas do prontuário da paciente, exames de neuroimagem e laudo anatomopatológico. Resultado: Foi observada a confirmação diagnóstica de neuroparacoccidioidomicose em mulher jovem, a qual inicialmente teve hipótese diagnóstica para tumor intracraniano. As descrições do relato de caso aqui apresentadas são atípicas, visto que, as características ocupacionais e perfil etário da paciente não a colocavam como grupo de risco para tal condição. Conclusão: O relato de caso de neuroparacoccidioidomicose foi considerado atípico devido aos biomarcadores associados, sendo aqui descrita a discussão sobre a construção diagnóstica.
Schwannoma vestibular em menores de 10 anos
Authors: Aragão Afonso Henrique de , Constanzo Felipe , Martins Lucas Piason de Freitas , Ramina Ricardo
Published: December 2021

Schwannomas vestibulares (SV) são entidades oncológicas benignas raras, sobretudo em pacientes pediátricos menores de dez anos, principalmente quando não associados a neurofibromatose tipo 2. O objetivo deste estudo é relatar um caso de SV não associado a NF2 em um paciente de oito anos com revisão na literatura. Utilizando a base de dados PubMed foram selecionados oito relatos de caso para revisão, chegando a maior prevalência no sexo masculino, maior frequência de paralisia do nervo facial como apresentação clínica e maior tendência à piora neurológica como desfecho pós-operatório.
Hematoma epidural tardio
Authors: Rocha Eckstanio Marcos Melo , Pereira Carlos Umberto
Published: December 2021

Introdução: O hematoma epidural (HE) tardio é definido como o hematoma que é insignificante ou não está presente no exame de tomografia computadorizada (TC) inicial após o trauma, mas no exame seguinte se apresenta como significativo em tamanho. Método: Paciente masculino, 35 anos de idade, vítima de acidente de trânsito. ECG na admissão 15. Exame neurológico: normal. TC de crânio realizado três horas após o trauma revelou pequena contusão no lobo frontal direito. Após 12 horas de observação desenvolveu baixa do nível de consciência e cefaleia. ECG 13. Novo exame de TC foi realizado e demonstrou HE frontal direito. Submetido a craniotomia osteoplástica e drenagem do hematoma. Recebeu alta bem. Conclusão: O HE em sua fase inicial pode ser pequeno e não necessitar de tratamento cirúrgico. Pode evoluir e apresentar sinais neurológicos focais e um novo exame de TC demonstrar aumento de volume do hematoma. Portanto, estes casos de hematoma ausente ou de pequeno volume, necessitam de vigilância neurológica intensa e, em caso de piora clínica, novo exame de TC. O tratamento cirúrgico tem sido indicado na presença de aumento de volume do hematoma com resultado excelente.
Bilateral thalamus stroke due to percheron artery
Authors: Demartini Junior Zeferino , Chaves Jennyfer Paulla Galdino , Lages Roberto , Cardoso Diogo , Gatto Luana Antunes Maranha , Koppe Gelson
Published: December 2021

Bilateral thalamus ischemic stroke is a rare condition that carries significant morbidity and mortality in comparison to other forms of stroke. It is usually associated with an anatomical variant with the thalamic paramedian arteries arising from a common trunk from the posterior cerebellar artery, known as Percheron artery. This infarct is difficult to be recognized and early recognition of this syndrome improves survival and functional recovery. We report a case of bilateral thalamic stroke after cardiac surgery.
Reversible Cerebral vasoconstriction syndrome associated with the use of sibutramine
Authors: Silva Joseph Franklin Chenisz da , Demore Caio Cesar , Reis Felipe Ibiapina dos , Stoliar Gabriel Abrahão , Pedro Matheus Kahakura Franco , Leal André Giacomelli
Published: December 2021

The reversible cerebral vasoconstriction syndrome, also known as Call-Fleming syndrome, was initially described in 1988, and is characterized by a clinical syndrome of headaches episodes, generally the “thunderclap” pattern, due to a deregulation of the vascular tonus, leading to segmentary cerebral vasoconstriction and secondary neurological deficits, including those by ischemic or hemorrhagic stroke. In this paper, we present two illustrative cases of this syndrome due to the use of sibutramine. To our knowledge, this situation hasn’t been described as related drug before.
Condroma Gigante da Região Parieto-Occipital: relato de caso e revisão de literatura
Authors: Soares Pedro Felipe , Silva Danilo Dias de França , Nunes Juliana Coelho , Conceição Renato Teixeira , Albuquerque Eduardo Alves Summers , Reis Lorena Silva dos , Lemos Gilcielma Gomes de , Noronha Bruno da Fonseca , Marques Fabrício Nery
Published: December 2021

Introdução: Condromas são tumores benignos, que normalmente se apresentam como lesões metafisárias solitárias. Contudo, mais raramente, tais lesões podem se manifestar com localização intracraniana. A apresentação clínica depende da exata localização do tumor e inclui cefaleia, convulsões, déficits neurológicos focais e papiledema. Neste artigo, apresentamos um caso de condroma na região parieto-occipital esquerda, juntamente a uma revisão sistemática da literatura. Relato de caso: Paciente do sexo feminino, 45 anos, se apresentou ao hospital com queixa de cefaleia temporo-parieto-occipital à esquerda, de caráter pulsátil, que evoluiu com náuseas, vômitos e fraqueza em membros inferiores. As neuroimagens evidenciaram lesão expansiva de 8,4 x 7,0 x 8,0 cm em região parietooccipital esquerda, com realce periférico irregular pelo contraste e áreas sugestivas de hemorragias ou calcificações em T2. A suspeita inicial foi de meningioma. Foi submetida a craniotomia temporo-parieto-occipital à esquerda, seguida de ressecção total do tumor e envio para análise anatomopatológica, sendo diagnosticado como condroma. Conclusão: Condromas intracranianos são entidades infrequentes e de progressão lenta. Eles não possuem sinais patognomônicos na neuroimagem e são frequentemente confundidos com meningiomas. A ressecção completa é indicada como principal terapêutica curativa, mostrando-se de bom prognóstico a longo prazo.
Large cavernous malformations in infant
Authors: Britz João Pedro Einsfeld , Sonda Ildo , Calloni Renato Luis , Bicca Yan , Aguzzoli Arthur
Published: December 2021

Cavernous malformations are rare vascular malformations in the central nervous system. We present the case of a 2-month-old female patient who presented tonic-clonic seizures, with no previous history of seizures. Magnetic resonance imaging showed a 5.6 cm tumor in the left parieto-occipital region. The radiological aspect of the tumor initially suggested an anaplastic meningioma. After surgical treatment and anatomopathological analysis, it was found to be a cavernous malformation. Cavernous malformations, or cavernomas, are rare lesions and even more rare is the occurrence of large cavernomas. In the pediatric population, although still quite rare, they usually are presented as larger cavernomas. Surgical resection is considered the most effective treatment.
Identificaciones policiales por perfil racial. Estudio criminológico sobre las experiencias de identificación en España en 2020-2021
Authors:   Universitat de Barcelona, Barcelona, España, Ziati Ziati Hassiba , Trespaderne Dedeu Ariadna ,   Universitat de Barcelona, Barcelona, España, Ziati Ziati Nassiba ,   Universitat de Barcelona, Barcelona, España, Soria Verde Miguel Ángel ,   Universitat de Barcelona, Barcelona, España
Published: December 2021

Uno de los temas principales respecto a las identificaciones policiales, es el uso de la raza como criterio en la toma de decisiones durante las retenciones por parte de la policía. Sin embargo, estudios previos han constatado que estas prácticas se concentran en mayor proporción en ciertos colectivos minoritarios, aplicando por ello el perfil étnico. A pesar de ser una práctica extendida en España y Europa, existen pocos estudios sobre las disparidades raciales entre grupos con relación a las identificaciones policiales. Por ello, la presente investigación pretende analizar las diferencias entre la población general y los grupos minoritarios con base en las experiencias de identificación policial en España durante 2020-2021. Para ello, se ha seguido una metodología cuantitativa, donde se han reportado los datos de identificaciones policiales por medio de un cuestionario con una muestra de 134 participantes. El análisis de los datos se ha realizado mediante asociación y modelo de regresión binaria. Los resultados sugieren la existencia de diferencias significativas entre grupos, en relación con las experiencias de identificación policial, pues las minorías étnicas son colectivos que tienen más probabilidades de ser señalados en comparación con la población general.
Factores regionales asociados al incumplimiento de normas de convivencia en tiempos de Covid-19 en Colombia
Authors:   Universidad Nacional de Colombia, Bogotá, Colombia, Ruiz-Pérez José Ignacio , Aparicio Barrera Juan ,   Policía Nacional de Colombia, Bogotá, Colombia
Published: December 2021

El objetivo de este trabajo fue conocer las relaciones entre las cifras de incumplimiento de siete restricciones impuestas por el aislamiento social establecido por la Covid-19 (Comportamientos Contrarios a la Convivencia, CCC) entre el 16 de marzo y el 1 de mayo de 2020, con indicadores económicos de criminalidad, de tejido social entre 2015 y 2018, y con el número de contagios del 2020 a nivel nacional y en Bogotá (n = 33). Entre los resultados se encontró a) correlación directa entre las tasas totales de CCC y tasas regionales de delitos contra la propiedad; b) relaciones directas entre infracciones por aglomeraciones y tasa de contagios por Covid-19; c) el clima emocional negativo y la insatisfacción con la policía se asociaron con infracciones por aglomeraciones y por falta de uso del tapabocas; d) más eficacia colectiva y afrontamiento comunal se asociaron con menos infracciones por consumo no autorizado de alcohol Aunque el tamaño de las correlaciones fue moderado, la evidencia apoya las teorías de la “ventana rota” y de la desorganización social.
Translation in the Context of Preserving Languages and Cultures of the Siberian Indigenous Population
Authors: Valkova Yulia E. , Razumovskaya Veronica A.
Published: December 2021

In this article weve focused on the topical problem of preserving the languages and cultures of indigenous peoples of Siberia, which can be solved through the translation of ethnic texts (as an important category of Siberian texts) into Russian and other languages, and translation of texts of great cultural and religious significance from Russian and other languages into languages of Siberian peoples. We aim to study initiatives of individual scholars and enthusiasts who have been translating both strong texts from indigenous languages of Siberian peoples and strong texts of Russian literature (mostly religious ones) into these languages. The ethnic literature of the peoples of the Krasnoyarsk Krai is considered in historical and comparative perspective, taking into account the national and cultural conditions of these peoples. The conclusion concerns the importance of ethnic translation with the cultural information and memory as the key unit of translation and the saving of the unique languages and cultures of Siberia as its main task.