bluuebunny/crossref_metadata_2025 huggingface dataset:
edTPA During Student Teaching: PETE Teacher Candidates’ Experiences and Future Support
Authors: Goh Tan Leng , Bishop Jan , Ciotto Carol
Published: October 2021

Many physical education teacher education programs require teacher candidates to successfully complete edTPA during student teaching. Considering that research remains sparse regarding best practices in edTPA, the purpose of this study was to understand the experiences of teacher candidates completing edTPA during student teaching and of university supervisors supervising teacher candidates during the process. Twenty-four teacher candidates and 11 university supervisors participated in a focus group discussion for approximately 1 hr. Data were analyzed and categorized as (1) negative experiences, (2) positive experiences, and (3) future support. Overall, the teacher candidates felt that completing edTPA diminished their student teaching experience, as it was tedious and time-consuming pertaining to technological difficulties in videotaping, video processing, and video uploading. Nonetheless, the participants felt that completing edTPA was valuable in providing teacher candidates with detailed feedback to improve on their pedagogical skills. Future support for teacher candidates includes integrating edTPA early in their curriculum of study to better prepare them to successfully complete edTPA during student teaching. The university supervisors felt that with more in-depth training in edTPA and experience supervising teacher candidates on edTPA, they would be more competent in the future. Subscribe to TPE
Graduate Teaching Assistants’ Experiences Using Digital Media Pedagogies in University Physical Activity Courses
Authors: Cox Dannon , Krause Jennifer
Published: October 2021

Many college and universities in the United States provide physical activity courses (PAC) for students to earn credit toward graduation. Institutions vary in PACs, as physical activity programs are affected by administrative goals and needs. Although PACs can vary by institution, it is important to examine how PACs can contemporarily address the cultural changes in education and physical activity. This study employed a case study research design and investigated the lived experiences of eight graduate teaching assistants working as PAC instructors at one university. Interview, observational, document collection, and technology journal data were collected throughout a 16-week semester. An interpretative phenomenological analysis of multiple variables, attitudes and beliefs, and pedagogical implementations resulted in four recurrent themes regarding the use of digital media in PACs: (a) experimenting with student engagement, (b) finding meaningful resources, (c) learning Canvas, and (d) valuing video and audio media. This article also provides future considerations around digital resources and professional development opportunities. Subscribe to TPE
Professional Preparedness and Psychosocial Beliefs as Predictors of Quality Physical Education and Recreation Services to Students with Disabilities
Authors: Kavanaugh Thea , Tomaka Joe , Moralez Ernesto
Published: October 2021

The purpose of this study was to examine how professional preparedness and psychosocial beliefs affected behavioral intentions and quality service behaviors in providing physical education (PE) and recreation services to students with disabilities (SWD). Participants of an online survey included New Mexico adapted physical education (APE) teachers (N=42) and recreational therapists (RT; N=13) and a sample of PE teachers (N=63). Analyses revealed significant differences between PE teachers and personnel in specialty professional disciplines. APE and RT personnel reported greater positive attitudes, higher self-efficacy, greater behavioral intention, and more engagement in quality service behaviors than PE teachers. The results have implications for the selection and training of school personnel hired to provide PE and recreation services to SWD.
Violencia de género contra las mujeres
Authors: Aragón García Victoria , Alcina Aznar Antonio Sergio
Published: October 2021

La violencia de género constituye un problema de actualidad que viene siendo visibilizado, desde hace unos años, a través de los medios de comunicación, pero que continúa relegado a una cuestión social menor, si se compara con otro tipo de formas de violencia, y que en cualquier caso responde a una actitud de culpabilidad y responsabilidad de maltratadores, e incluso de las propias víctimas. Sin embargo, los datos que encontramos, con variaciones regionales, son alarmantes y permean todas las sociedades. Partiendo de la idea de que existe relación entre violencia de género y desigualdad, este trabajo analiza la arquitectura social a partir de la cual se construye, legitima y perpetúa esa violencia. Para llevar a cabo este objetivo utilizamos una metodología que abarca el análisis bibliográfico, y datos procedentes de distintas fuentes estadísticas y artículos. El resultado sugiere que existe un escenario de subrepresentación social, económica e institucional de la mujer, que lleva a una subvaloración de la misma, y que da lugar a una aceptación silenciosa de la violencia contra ella, en todos los niveles, lo que nos permite afirmar que la violencia es estructural, sobrepasa la pura agresión física o verbal en el contexto familiar, y que, en consecuencia, existe una complicidad institucional.
Mãe, raiz do morro
Authors: Silvério Vânia Pereira , Alves Liliane da Silva , Pereira Josemeire Alves
Published: October 2021

Neste artigo será analisado o processo de construção da peça Mãe, Raiz do Morro, do Grupo Teatro Entre Elas, da Casa do Beco, formado por senhoras moradoras da comunidade do Morro do Papagaio (BH), em diálogo com os apontamentos traçados por Nogueira (2008) sobre o campo do Teatro em Comunidades. Para tanto, será evidenciado o contexto comunitário e o uso de histórias pessoais e locais na construção dramatúrgica.
Manifestações do teatro no Rio Grande do Norte
Authors: Oliveira Adriano Moraes de , Melo Eduardo Augusto Martins de , Gomes Quemuel Costa , Guerra Pedro Samuel de Medeiros
Published: October 2021

Este artigo apresenta quatro cenários distintos de manifestações teatrais do Rio Grande do Norte (RN). Escrito por pesquisadores que integram uma base de pesquisa sobre teatro de grupo na UFRN, busca-se pensar a relação entre o teatro e a comunidade a partir das seguintes perspectivas: o teatro e a universidade, as teatralidades da cena popular, o teatro de grupo e o teatro em contexto escolar.
Percurso de implantação do terceiro ciclo para aprendizagem na rede pública de ensino do Distrito Federal
Authors: Ferreira Valdivina Alves , Chagas Alisson Moura , Souza Thamara Maria de
Published: October 2021

O texto objetiva refletir acerca dos Ciclos para as Aprendizagens implementados na rede pública de ensino do Distrito Federal, legitimados pela Lei n. 5.499, de 14/7/2015, que aprova o Plano Distrital de Educação (PDE). Assim, a partir da promulgação do PDE (2015), as escolas, em substituição à organização seriada, passam a se organizar em ciclos para as aprendizagens. É uma pesquisa bibliográfica e documental. Mesmo com os aspectos legais, compreende-se que esse processo de organização escolar deve ser implementado com cautela, uma vez que a legislação é base dessa política pública, porém as leis não a sustentam por si só. Os dados analisados indicam a preocupação com a retenção dos estudantes, bem como a formação continuada para atuarem nos ciclos. Observa-se que não basta trocar a forma de organização da escolaridade, é preciso instrumentalizar os docentes para que possam materializar a política nas salas de aula.
Cultura visual, gênero e embalagens de jogos de ciência: (Como) meninas brincam de ciência?
Authors: Baliscei João , Vagliati Ana Carla
Published: October 2021

As representações de adultos/as sobre o que é considerado feminino e masculino reforçam estereótipos de gênero e, com isso, brinquedos, jogos e demais artefatos da cultura visual tendem a caracterizar meninos e meninas de formas diferentes. Como as identidades de gênero de meninas e meninos são representadas nos jogos infantis de ciência? As meninas aparecem nas embalagens desses jogos? Quando aparecem, como são apresentadas? Para responder a essas questões, neste artigo, de cunho documental e analítico, temos como objetivo problematizar as representações de ciência e feminilidade nas embalagens de jogos infantis. Para tanto, investigamos 38 embalagens de jogos infantis de ciência comercializados em 2017. Durante a análise, dividimos esse montante de embalagens em cinco grupos, os quais foram investigados sob fundamentos dos Estudos de Gênero e Estudos da Cultura Visual. Avaliamos que as embalagens de jogos científicos analisadas sugerem um “não protagonismo” feminino nos jogos de ciências. Constatamos, nesses artefatos, a ausência de endereçadores visuais que convidem as meninas a brincarem/fazerem ciência − ao menos que as atividades envolvam os cuidados com o corpo, os afazeres domésticos e a atuação como auxiliares.
Desafios ao Bacharelado em Administração Pública do Instituto Federal da Paraíba para a melhoria do processo avaliativo no contexto do SINAES
Authors: Paiva Marcos Vasconcelos , Guerra Maria das Graças Gonçalves Vieira
Published: October 2021

O objetivo da pesquisa é identificar os novos desafios à gestão do Bacharelado em Administração Pública (BAP), na modalidade de Educação a Distância (EaD) ofertado pelo Instituto Federal da Paraíba (IFPB), João Pessoa, diante da atualização do instrumento de avaliação de cursos de graduação (IACG) no ano de 2017, com foco no instrumento utilizado para a renovação e o reconhecimento de curso. A investigação consiste em um estudo de caso, de natureza aplicada, abordagem qualitativa e objetivo descritiva, com a coleta de dados realizada por procedimento documental. Foram analisados cinco indicadores de desempenho de conceito 3, menor valor obtido no último relatório de avaliação externa in loco do curso, identificados como: material didático institucional; gabinetes de trabalho para professores em Tempo Integral; espaço de trabalho para coordenação do curso e serviços acadêmicos; sala de professores; e salas de aula. Destacaram-se, ainda em análise, quatro indicadores incluídos no novo IACG, com aplicações comprovadas ao BAP: conhecimentos, habilidades e atitudes necessárias às atividades de tutoria; Ambiente Virtual de Aprendizagem (AVA); equipe multidisciplinar; e experiência no exercício da docência na EaD. Propõe-se, com a apresentação dos resultados, evidenciar os aspectos de insuficiência e os novos indicadores relacionados ao BAP que auxiliem os gestores nas tomadas de decisões diante das novas demandas do IACG, objetivando a melhoria da qualidade do processo avaliativo.
Currículo e (de)colonialidade: a potência decolonial em escolas com baixo IDEB
Authors: Pavan Ruth , Lizott Tedeschi Sirley
Published: October 2021

O artigo, fruto de projeto de pesquisa com apoio do CNPq, pretende mostrar, por meio da análise de entrevistas com professoras e professores que atuam em escolas públicas com baixo Índice de Desenvolvimento da Educação Básica (IDEB), que há potência decolonial em escolas (des)classificadas pelas avaliações em larga escala como tendo baixa qualidade. Inicialmente, fazemos uma discussão do currículo e da colonialidade. Em seguida, trazemos as incursões metodológicas, com destaque para a escolha dos sujeitos e para o instrumento de coleta de dados, articulando-as com a concepção teórica, pautada em autores do campo crítico, sobretudo em autores da decolonialidade. Segue, então, a análise da pesquisa de campo. Por fim, apresentamos algumas conclusões, de caráter provisório, pois entendemos, juntamente dos autores e das autoras que trazemos neste artigo, que tanto o conhecimento quanto o currículo são campos dinâmicos, portanto, sem possibilidade de oferecer conclusões definitivas e fechadas. As falas analisadas das professoras e dos professores situam-se, ainda que de forma tênue, na perspectiva da denúncia, ao criticarem o racismo e o currículo oficial, mas também se situam na perspectiva das alternativas ao inserirem o contexto e a realidade dos alunos, vendo neles conhecimentos importantes a serem incluídos no currículo.
Akaniaceae, a new family record for Laos
Authors:   Department of Biology, Faculty of Natural Science, National University of Laos, Vientiane, Laos, Lanorsavanh Soulivanh , Lamxay Vichith ,   Department of Biology, Faculty of Natural Science, National University of Laos, Vientiane, Laos, Mattapha Sawai ,   Department of Biology, Faculty of Science, Udon Thani Rajabhat University, Udon Thani 41000, Thailand, Souvannakhoummane Keooudone ,   Department of Biology, Faculty of Natural Science, National University of Laos, Vientiane, Laos, Chanthavongsa Khamfa ,   Department of Biology, Faculty of Natural Science, National University of Laos, Vientiane, Laos, Bounphanmy Somchanh ,   Department of Biology, Faculty of Natural Science, National University of Laos, Vientiane, Laos
Published: October 2021

A collection from Phou Chom Voy Provincial Protected Area, Bolikhamxai, represents the first records for the family Akaniaceae as well as the genus Bretschneidera and the species Bretschneidera sinensis in Laos. Here we report the new and extended distributional range. A detailed description and photographs are provided for easy identification.
CYCLES OF SOLAR ACTIVITY AS A BASIS FOR FORECASTING THE QUALITY OF DNIEPER WATER
Authors: Kulishenko Oleksiy , Klymenko Natalia
Published: October 2021

One of the main features of the quality of the Dnieper water is the content of natural organic substances which determine the water oxidizability and color indexes. A special problem is that organic substances are poorly removed by water treatment plants. A significant problem in the operation of water treatment plants is the unpredictability of annual changes in the quality of Dnieper water, which complicates logistics management, for example, the supply of reagents. Many years of experience related to the Dnieper water supply station in Kyiv (DnWS) have led to the hypothesis that these changes are in some way related to the cycles of solar activity.

The purpose of this work is to test this hypothesis to substantiate the possibility of predicting the quality of Dnieper water depending on the action of such a global factor as solar activity. The work was performed by statistical methods using 60-year results of Dnieper water analyzes provided by the DnWS laboratory, as well as Wolf numbers (Sunspot Numbers) provided for free use by the Royal Observatory of Belgium. The influence of solar activity on the quality indicators of Dnieper water, especially in its peak and post-peak periods, has been statistically confirmed. The interaction of biological and physicochemical parameters as factors influencing water quality is shown.

Conclusions. As a result of the construction of six reservoirs in 1931-1976, the Dnieper from the river actually turned into a network of water bodies. Now these reservoirs are a kind of reactors in which water is treated by electromagnetic solar radiation, which leads to the cyclic transformation of phytoplankton and natural organic matter. Taking into account the cycles of solar activity, the logistical planning of the operation of water treatment facilities receives an independent "base", changes in which can be predicted with some reliability for years to come.
TECHNOLOGY OF COMPLEX SORPTION TREATMENT OF INDUSTRIAL WASTEWATER FROM SULPHIDE AND COPPER(II)–IONES
Authors: Khudoyarova Olga , Ranskiy Anatoliy , Gordienko Olga
Published: October 2021

Complex processing of industrial waste of individual industries, including wastewater treatment, containing sulfur anions and cations of heavy metals, in order to obtain both purified water and finished industrial products is an urgent task for today. The possibility of efficient use of regenerated mixed sorbent (AC+K), containing activated carbon (AC) and diatomaceous earth (K), for wastewater treatment of certain technological processes of chemical (petrochemical) industry and galvanic industries has been shown. The sorbent with the removed contaminants was offered to be utilized as a part of plastic lubricants of special purpose. The technological process of complex sorption treatment of industrial wastewater from sulfide and copper (II) ions includes the following main stages: sorbent regeneration; purification of sulfide-alkaline solutions; purification of washing waters of galvanic productions; obtaining plastic oils. The basic technological scheme of the site of regeneration of the spent mixed sorbent (AC+K) and purification of water-sugar solutions from organic impurities was developed. The material balance of regeneration of the spent mixed sorbent was calculated. The basic technological scheme of the site of combined treatment of industrial wastewater from sulfide and copper (II) ions, regeneration of spent industrial oils with regenerated sorbent (AC+K) and production of plastic oils has been developed. It was shown that the technology of complex sorption wastewater treatment is based on the most common technological processes - heating, cooling, adsorption and filtration and does not require complex schemes of automatic process control, and chemical equipment is typical for chemical enterprises in Ukraine. The economic effect of production of special purpose plastic oils was calculated.
ECONOMICAL AND ENVIRONMENTAL BENEFITS OF POINT-OF-USE NaCl BRINE REUSE BY NEW MEMBRANE TECHNOLOGY
Authors: Orestov Yevhen , Mitchenko Tetiana , Vasilyuk Sergey
Published: October 2021

Cation exchange water softening is one of the most widely used technologies of water treatment. However, its environmental impact related to discharge of highly concentrated regeneration brine draws more attention as overall quality and availability of water resources decreases. Bearing in mind high levels of reusable NaCl in brine discharge, technology that will reduce the environmental impact and help reuse brine is required. To develop such technology composition of spent brine solution from Na-cation exchanger was investigated and conditioning of such solution with use of nanofiltration membranes of different types under different temperatures, pressures and recovery values was tested. Results show that optimal conditions for NaCl recovery include usage of DuPont (Dow) Filmtec Fortilife XC-N membrane elements at temperature 23-27 °С, pressure of 23-25 bar and recovery of 55-60 %. Under these conditions purity of NaCl in permeate over 90 % and productivity by NaCl of 13.1 kg/h were achieved. Principal technological scheme of the process of membrane conditioning of the spent regeneration solution was proposed that allows achieving reduction of NaCl consumption by 40 % and reduction of NaCl discharge into sewage by 72 % with corresponding economic and environmental benefits.
Tannins Compound In Soga Tingi Bark (Ceriops Tagal) As Natural Dyes
Authors: Paryanto Paryanto , Pranolo Sunu Herwi , Susanti Ari Diana , Putrikatama Bintang Timur , Qatrunada I. R. , Wibowo Angga Dwi
Published: October 2021

In general, natural dyes for textile materials are obtained from extracts part of the plants such as roots, wood, leaves, seeds, and flower. Textile industry especially batik craftsman, have known many plants that can dye textile materials, such as indigo (indigofera), soga tingi bark (Ceriops tagal), tegeran wood (Cudraina javanensis), turmeric (Curcuma), tea (The), noni root (Morinda citrifelia), soga jambal bark (Pelthophorum ferruginum), kesumba (Bixa orelana), and guava leaf (Psidiumguajava). Soga tingi bark chosen because it can produce tannins which can be used as natural dyes. The purpose of this research was to obtained tannin content in soga tingi bark as qualitatively and quantitatively. The analysis carried out is FTIR and HPLC method. FTIR analysis carried out to determine of the compounds contained in the soga tingi bark extraction. Based on FTIR analysis it can be seen that there are O-H and N-H group in the wavenumber 3375,13 cm-1. C=O bond at wavenumber 1739,16 cm-1. C=C bond at wavenumber 1624,31 cm-1. C-H bond at wavenumbers 2970,72 cm-1, 1456,39 cm-1, and 1365,74 cm-1. NO2 bond at wavenumber 1365,74 cm-1. C-N bond at wavenumbers 1228,69 cm-1 and 1217,34 cm-1. And C-O bond at wavenumbers 1228,69 cm-1, 1217,34 cm-1, and 1052,3 cm-1. While HPLC analysis carried out to determine contains tannin level in the soga tingi bark extraction. HPLC conditions used are Flowrate: 1 mL/min, Mobile phase: MeOH : H2O (50:50), λ: 271 nm and Column: C18, 250 mm. Based on HPLC analysis it is known that the contains tannin level in the soga tingi bark extraction is 22,44 ppm.
Dampak Bantuan Langsung Tunai terhadap Ketahanan Pangan Rumah Tangga di Indonesia
Authors: Amrullah Eka Rastiyanto , Pullaila Ani , Hidayah Ismatul , Rusyiana Aris
Published: October 2021

English
Direct cash transfer is widely used to strengthen food security and reduce household vulnerability to poverty. In Indonesia, direct cash transfer (BLT) has lasted several decades. However, there are still problems in its implementation. This study aims to analyze the effect of BLT on the food security of household-recipients. The data source used was Susenas March 2015, with a total sample of 285,908 households, comprising 55,238 BLT recipients and 230,670 non-recipients. PSM and IPWRA estimators were used to estimate the ATET indicator of food security. The analysis results showed that BLT positively impacted recipient households in terms of calorie and protein intake per capita/day. BLT also has a positive effect on per capita food expenditure and the share of food expenditure. Besides, BLT impacts a change in the percentage of food expenditure; there is a shift in food consumption from the root crops, animal food, fruit, and vegetables to grains, processed food and beverages, and cigarettes. There has been a change in food consumption patterns in recipient households to become more consumptive. However, providing BLT alone is not enough. It should be combined with other social safety net programs to increase the food security of poor households. 

Indonesian
Bantuan langsung semakin banyak digunakan untuk memperkuat ketahanan pangan dan mengurangi kerentanan kemiskinan. Di Indonesia, Bantuan Langsung Tunai (BLT) telah berlangsung beberapa dekade. Akan tetapi, dalam pelaksanaannya terdapat beberapa permasalahan, di antaranya ketidaktepatan sasaran. Penelitian ini bertujuan menganalisis dampak program BLT terhadap ketahanan pangan penerima. Sumber data adalah Susenas Maret 2015, dengan sampel 285.908 rumah tangga, terdiri dari 55.238 penerima BLT dan 230.670 bukan penerima. Metode PSM dan IPWRA digunakan untuk menduga ATET indikator ketahanan pangan. Hasil analisis menunjukkan bahwa pemberian BLT memberikan dampak positif bagi rumah tangga penerima dalam aspek asupan kalori dan protein per kapita/hari. BLT juga berdampak positif terhadap pengeluaran pangan per kapita dan pangsa pengeluaran pangan. Selain itu, BLT berdampak pada perubahan pangsa pengeluaran pangan yang ditunjukkan oleh terjadinya pergeseran konsumsi pangan dari kelompok pangan umbi-umbian, pangan hewani, buah dan sayur menuju kelompok padi-padian, makanan dan minuman jadi, serta rokok. Terjadi perubahan pola konsumsi pangan pada rumah tangga penerima menjadi lebih konsumtif. Secara keseluruhan, BLT mampu memberikan dampak positif terhadap beberapa indikator ketahanan pangan. Pemberian BLT saja tidak cukup untuk memberikan makanan yang cukup dan bergizi bagi rumah tangga penerima. Perlu ada kombinasi antara bantuan langsung tunai dengan program jaring pengaman sosial lainnya yang bertujuan untuk meningkatkan ketahanan pangan rumah tangga miskin.
Geomechanical Response Induced by Multiphase (Gas/Water) Flow in the Mallik Hydrate Reservoir of Canada
Authors: Xia Yingli , Xu Tianfu , Yuan Yilong , Xin Xin , Zhu Huixing
Published: October 2021

Natural gas hydrate (NGH) is regarded as an important alternative future energy resource. In recent years, a few short-term production tests have been successfully conducted with both permafrost and marine sediments. However, long-term hydrate production performance and the potential geomechanical problems are not very clear. According to the available geological data at the Mallik site, a more realistic hydrate reservoir model that considers the heterogeneity of porosity, permeability, and hydrate saturation was developed and validated by reproducing the field depressurization test. The coupled multiphase and heat flow and geomechanical response induced by depressurization were fully investigated for long-term gas production from the validated hydrate reservoir model. The results indicate that long-term gas production through depressurization from a vertically heterogeneous hydrate reservoir is technically feasible, but the production efficiency is generally modest, with the low average gas production rate of 4.93 × 103 ST m3/d (ST represents the standard conditions) over a 1-year period. The hydrate dissociation region is significantly affected by the reservoir heterogeneity and reveals a heterogeneous dissociation front in the reservoir. The depressurization production results in significant increase of shear stress and vertical compaction in the hydrate reservoir. The response of shear stress indicates that the potential region of sand migration is mainly in the sand-dominant layer during gas production from the hydraulically heterogeneous hydrate reservoir (e.g., sand layers interbedded with clay layers). The maximum subsidence is approximately 78 mm and occurred at the 72nd day, whereas the final subsidence is slowly dropped to 63 mm after 1-year of depressurization production. The vertical subsidence is greatly dependent on the elastic properties and the permeability anisotropy. In particular, the maximum subsidence increased by approximately 81% when the ratio of permeability anisotropy was set at 5:1. Furthermore, the potential shear failure in the hydrate reservoir is strongly correlated to the in-situ stress state. For the normal fault stress regime, the greater the initial horizontal stress is, the less likely the hydrate reservoir is to undergo shear failure during depressurization production.
Rationale and design of the Brazilian Diabetes Study: a prospective cohort of type 2 diabetes
Authors: Barreto Joaquim , Wolf Vaneza , Bonilha Isabella , Luchiari Beatriz , Lima Marcus , Leite Alessandra Oliveira , Vitte Sofia , Machado Gabriela , Cunha Jessica , Borges Cynthia , Munhoz Daniel , Fernandes Vicente , Kimura-Medorima Sheila Tatsumi , Breder Ikaro , Fernandez Marta Duran , Quinaglia Thiago , Oliveira Rodrigo Bueno , Chaves Fernando , Arieta Carlos , Junior Gil Guerra , Avila Sandra , Nadruz Wilson , Carvalho Luiz Sergio Fernandes , Sposito Andrei C
Published: October 2021

Background.
Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality of individuals with diabetes. Employment of machine learning (ML) techniques aimed at identification of novel features of risk prediction is a compelling target to tackle residual cardiovascular risk.
Objective.
To identify clinical phenotypes of T2D which are more prone for developing cardiovascular disease.
Methods.
The Brazilian Diabetes Study is a single-center, ongoing, prospective registry of T2D individuals. Eligible patients are 30 years-old or older, with a confirmed T2D diagnosis. After an initial visit for signature of informed consent form and medical history registration, all volunteers undergo biochemical analysis, echocardiography, carotid ultrasound, ophthalmologist visit, dual x-ray absorptiometry, coronary artery calcium score, polyneuropathy assessment, advanced glycation end-products reader, and ambulatory blood pressure monitoring. A 5-year follow-up will be conducted by yearly phone interviews for endpoints disclosure. The primary endpoint is the difference between ML-based clinical phenotypes in the incidence of a composite of death, myocardial infarction, revascularization, and stroke. Since June/2016, 1030 patients (mean age: 57 years, diabetes duration of 9.7 years, 58% male) were enrolled in our study. Mean follow-up time was 3.7 years in October/2021.
Conclusions.
The BDS will be the first large population-based cohort dedicated to the identification of clinical phenotypes of T2D at higher risk of cardiovascular events. Data derived from this study will provide valuable information on risk estimation and prevention of cardiovascular and other diabetes-related events.
ClinicalTrials.gov Identifier:
NCT04949152
Investigation of the Potential Serum Levels of Autophagy 5–protein, Apo-Lipoprotein B-48, and Oxidative Stress Markers in the Early Diagnosis of Patients with Ischemic Stroke
Authors: Ajoolabady Amir , Sogutlu Fatma , Nikanfar Masoud , Nourazarian Alireza , Laghousi Delara , shademan behrouz
Published: October 2021

Background: Stroke is one of the leading causes of death worldwide and has different characteristics. Different physiopathological mechanisms characterize the different subtypes of ischemic stroke. In this study, we investigated the correlation between serum levels of autophagy-5 protein, Apo-lipoprotein B-48, and oxidative stress markers in patients with ischemic stroke. Methods and results: We enrolled 100 participants, including 50 ischemic stroke (IS) patients as the case group and 50 healthy individuals as the control group. Then, we conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. We quantified the serum levels of ATG5, Apo B-48, and oxidative stress markers in both groups. And we evaluated the incremental diagnostic value of these factors by receiver operating characteristic analysis (ROC) in both groups. The mean serum levels of ATG5, Apo B-48, and oxidative stress markers were higher in the case group than in the control group, with a p–value of less than 0.0001 (p <0.0001).Conclusions: Serum levels of ATG5, Apo B-48, Malonaldehyde (MDA), total oxidative stress (TOS), and total antioxidant capacity (TAC) in patients with IS can be used as novel biomarkers to predict or therapeutically modulate patients with IS.
Predictive Modelling Physico-chemical Properties Groundwater in Coastal Plain Area of Vinhlinh and Giolinh Districts of Quangtri Province, Vietnam
Authors: Giang Nguyen Hong , Hieu Tran Dinh , Do Hoang Ngo Tu
Published: October 2021

This paper presents to study the performance of machine learning techniques consisting of Multivariate Adaptive Regression Spline(MARS), Multilayer Perceptron (MLP), and Decision Tree Regression (DTR) for estimating physico-chemical properties groundwater in coastal plain area in Vinhlinh and Giolinh districts of Quangtri province of Vietnam. To deploy the MLP and DTR, different types of transfer and kernel functions were tested, respectively. Determining the results of MARS, MLP and DTR showed that three models have suitable carrying out for forecasting water quality components. Comparison of outcomes of MARS model with MLP, DTR models indicates that this model has good performance for forecasting the elements of water quality, its level of accuracy is slightly more than other. To assess the accurate values of the models according to the measurement parameters indicated that order models were MARS, DTR, and MLP, respectively.
Performance Evaluation of a 4🞩20 Gbps OFDM-based FSO Link Incorporating Hybrid W-MDM Techniques
Authors: Joseph Deepti , Appathurai Karthikeyan , G Kuppusamy P , V Prabhu
Published: October 2021

Free space optics has been envisioned as an crucial technique to meet the high-bandwidth requirements in future wireless information transmission links and a feasible solution to the last-mile bottleneck problem. This research work reports the designing and simulative evaluation of the performance of high-speed orthogonal frequency division multiplexing-based free space optics link by incorporating wavelength division multiplexing of 2 independent frequency channels (193.1 THz and 193.2 THz) along with mode division multiplexing of distinct spatial laser Hermite Gaussian modes (HG01 and HG03). 4 independent 20 Gbps quadrature amplitude modulated data signals are transported simultaneously under different atmospheric weather conditions using the proposed link. Also, the link performance has been investigated for increasing beam divergence angle.
A GIS-based flood risk mapping of Assam, India, using the MCDA-AHP approach at the regional and administrative level
Authors: Gupta Laxmi , Dixit Jagabandhu
Published: October 2021

Floods are hydrological disasters that can alter the physical, socioeconomic, and environmental settings of a region. The objective of the present study is to develop an efficient and reliable methodology to prepare a flood risk map for Assam, the North-eastern region (NER) of India, by the integration of hazard and vulnerability components. Three indices, namely flood hazard index (FHI), flood vulnerability index (FVI), and flood risk index (FRI), are developed using multi-criteria decision analysis (MCDA) – Analytical hierarchy process (AHP) approach in GIS environment for the regional and administrative level of Assam. The selected hazard and vulnerability indicators define the topographical, geological, meteorological, drainage characteristics, land use land cover, and demographical features of Assam. The results show that more than 70% of the total area lies in the moderate to very high FHI class, 57.37% have moderate to high FVI, and more than 50% have moderate to very high FRI class.
A single-cell atlas reveals tumor heterogeneity and immune environment of acral melanoma
Authors: Yang Jilong , Zhang Chao , Shen Hongru , Yang Tielong , Li Ting , Liu Xinyue , Wang Jin , Liao Zhichao , Wei Junqiang , Lu Jia , Liu Haotian , Xiang Lijie , Yang Yichen , Yang Meng , Wang Duan , Li Yang , Xing Ruwei , Teng Sheng , Zhao Jun , Yang Yun , Zhao Gang , Li Xiangchun , Chen Kexin
Published: October 2021

Acral melanoma is a dismal subtype of melanoma occurring at the extremities of dark-skinned people. We performed single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cutaneous melanoma samples to investigate tumor cellular ecosystem particularly the heterogeneity and immune environment. We defined 5 orthogonal cell clusters that were involved in TGF-beta signaling, Type I interferon, Wnt signaling, Cell cycle, and Cholesterol efflux signaling. Signatures of TGF-beta signaling and cholesterol efflux are significantly associated with prognosis of melanoma. Compared with cutaneous melanoma, acral melanoma samples had significantly severe immunosuppressive state including depletion of cytotoxic CD8 + T cells, enrichment of Treg cells, and exhausted CD8 + T cells. PDCD1 (PD-1) and HAVCR2 (TIM-3) had higher expression in the exhaustive CD8 + T cells of acral melanoma. In summary, we have uncovered the tumor heterogeneity and immune infiltration characteristics of acral melanoma. Our findings may help to understand and guide the immunotherapy of acral melanoma.
WITHDRAWN: A Trust-Based Blockchain System for Production and Comprehension of Implicatures by Middle Eastern Speakers of English
Authors: hussein Sami , Mohammadzadeh Behbood
Published: October 2021

This research examined how well Kurdish EFL students interpret and generate implicatures in the same way as native English speakers do. Thus, a multiple-choice discourse completion test and a written discourse completion task were answered by 109 Kurdish EFL university students (42 males and 67 females) and 20 native English speakers (7 males and 13 females).The data were analyzed using SPSS, the Gricean framework (1975), and a rating rubric developed by Jernigan (2007).The results unveiled Kurdish EFL learners have a low level of implicature comprehension as well as production. As opposed to particularized implicatures, participants were more successful in the interpretation of generalized ones. Data showed learners had difficulty understanding conversational implicatures that are context-dependent and sensitive to culture. Data also revealed that transfer of knowledge and mother tongue seem to govern the way in which they comprehend and produce implicatures.Moreover, the findings showed female learners outperformed their male counterparts in the tests. Likewise, private university learners performed better than public university students. Since this examination contains huge amount of data, security is a major concern. Blockchain provides a creative technique to store data, perform functions, and establish trust in an open environment. Hence, the entire analysis is performed in a trust- based blockchain system for the security and privacy of the data.
The Aftermath of Tapering Tocilizumab After Achieving Treatment Target In Patients With Rheumatoid Arthritis: A Nationwide Cohort Study
Authors: Park Jun Won , Kim Min Jung , Kim Hyoun-Ah , Kim Jin Hyun , Lee Eun Bong , Shin Kichul
Published: October 2021

Background: Although recent guidelines recommend that tapering of biologic disease-modifying anti-rheumatic drugs (bDMARDs) can be considered in patients with rheumatoid arthritis (RA), there has been little evidence supporting the strategy during the non-tumor necrosis factor inhibitor treatment. This study aims to investigate the effectiveness and safety of tapering tocilizumab (TCZ) dose in patients with RA who attain low disease activity (LDA) after TCZ therapy in a nationwide cohort.Methods: Data were collected from a nationwide cohort of patients with RA receiving biologic disease-modifying anti-rheumatic drugs in South Korea (KOBIO-RA). This study included 350 patients who were treated with TCZ and achieved Clinical Disease Activity Index-low disease activity (CDAI)-LDA (CDAI ≤ 10) after 1 year of treatment. We performed longitudinal analysis considering clinical data measured at all 1-year intervals for the included patients using the generalized estimating equation. A total of 575 intervals were classified into two groups according to their dose quotient (DQ) of TCZ (tapering group vs. standard-dose group). The main outcome was maintaining CDAI-LDA in the following 1-year interval.Results: Tapering TCZ dose strategy was used in 282 (49.0%) intervals with a mean (SD) DQ of 66.0 (15.5) %. Loss of CDAI-LDA occurred in 91 (15.1%) intervals. Multivariable GEE showed that the tapering group was associated with more frequent failure to sustain CDAI-LDA (adjusted OR [95% CI]: 0.57 [0.33–0.99]), which subsequently led to impaired functional status. The likelihood of achieving DAS28-deep remission (DAS28-ESR<1.98) was also significantly lower in the tapering group (adjusted OR 0.68 [0.46–0.99]). CDAI remission was achieved in only 69 (12.0%) of the total intervals, with no significant difference in the proportion of intervals achieving the target between the two groups. Incidence of adverse events was comparable in both groups except for hypercholesterolemia, which was lower in the tapering group. Conclusions: Tapering TCZ dose after achieving LDA increases the risk of losing LDA without a significant merit in safety.
Adverse Childhood Experiences and Depressive Symptoms Among Female Sexual Minorities in China
Authors: Zhu Biao , Ding Changmian , Wang Liyin , Yan Hong , Jiang Qingqing , Tian Jiawei , Xiao Chenchang , Wei Liqing
Published: October 2021

Background: Despite the relationship between Adverse childhood experiences (ACEs) and depressive symptoms, which has been well conducted in general populations, little is known about homosexual and bisexual populations, especially female sexual minorities in China. This study aims to investigate the prevalence of ACEs and depressive symptoms and to analyze the relationship between them among female sexual minorities in China.Methods: The eligible participants were aged 16 years or older who report their sexual orientation as homosexual or bisexual. The data was collected through anonymous questionnaires under the help of Lespark in Bejing from July 18 to December 29, 2018. Univariate analysis and multiple linear regression analyses were performed to explore the relationship between ACEs and depressive symptoms among female sexual minorities. All statistical analyses were conducted by the software of SPSS 22.0.Results: Among 301 female sexual minorities,51.5% reported at least one ACE, in which emotional neglect (22.6%) and emotional abuse (22.3%) were common ACEs. 24.6% reported that they had suffered only one type of ACE, and 10% have suffered four or more ACEs. As for depressive symptoms of female sexual minorities, the detection rate was 56.1%. The multiple linear regression analyses showed that abuse (β=2.95, p＜0.05) and neglect (β=3.21,p＜0.05) were positively correlated with depressive symptoms and female sexual minorities with three (β=4.11, p＜0.05) or more (β=6.02, p＜0.001) ACEs suffered from more depressive symptoms than others. Conclusion: Both ACEs and depressive symptoms were at high prevalence among female sexual minorities in China. ACEs were associated with depressive symptoms, especially childhood abuse and neglect experiences that have a significant effect on female sexual minorities’ mental health.
Cumulative Incidence of SARS-CoV-2 Infection and Associated Risk Factors Among Frontline Health Care Workers in Paris, France: The SEROCOV Prospective Cohort Study
Authors: Hausfater Pierre , Boutolleau David , Lacombe Karine , Beurton Alexandra , Dumont Margaux , Constantin Jean-Michel , Ghosn Jade , Combes Alain , Cury Nicolas , Guedj Romain , Djibré Michel , Bompard Rudy , Mazerand Sandie , Pourcher Valérie , Gimeno Linda , Marois Clemence , Teyssou Elisa , Marcelin Anne-Geneviève , Hajage David , Tubach Florence
Published: October 2021

Objective

With the COVID-19 pandemic, documenting whether health care workers (HCWs) are at increased risk of SARS-CoV-2 contamination and identifying risk factors is of major concern.
Methods

In this multicenter prospective cohort study, HCWs from frontline departments were included in March and April 2020 and followed for 3 months. SARS-CoV-2 serology was performed at month 0 (M0), M1, and M3 and RT-PCR in case of symptoms. The primary outcome was laboratory-confirmed SARS-CoV-2 infection at M3. Risk factors of laboratory-confirmed SARS-CoV-2 infection at M3 were identified by multivariate logistic regression.
Results

Among 1,062 HCWs (median [interquartile range] age, 33 [28-42] years; 758 [71.4%] women; 321 [30.2%] physicians), the cumulative incidence of SARS-CoV-2 infection at M3 was 14.6% (95% confidence interval [CI] [12.5; 16.9]). Risk factors were the working department specialty, with increased risk for intensive care units (odds ratio 1.80, 95%CI [0.38; 8.58]), emergency departments (3.91 [0.83; 18.43]) and infectious diseases departments (4.22 [0.92; 18.28]); active smoking was associated with reduced risk (0.36 [0.21; 0.63]). Age, sex, professional category, number of years of experience in the job or department, and public transportation use were not significantly associated with laboratory-confirmed SARS-CoV-2 infection at M3.
Conclusion

The rate of SARS-CoV-2 infection in frontline HCWs was 14.6% at the end of the first COVID-19 wave in Paris and occurred mainly early. The study argues for an origin of professional in addition to private life contamination and therefore including HCWs in the first-line vaccination target population. It also highlights that smokers were at lower risk.
Trial registration:

The study has been registered on ClinicalTrials.gov: NCT04304690 first registered on 11/03/2020.
Safety and Efficacy of Anti-Inflammatory Therapy in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis
Authors: Niu Ying , Bai Nan , Ma Ying , Zhong Peng-Yu , Shang Yao-Sheng , Wang Zhi-Lu
Published: October 2021

Background
The inflammation hypothesis of atherosclerosis has been put forward more than 20 years. Although many animal experiments have suggested that anti-inflammatory therapy can inhibit the atherosclerotic process, the efficacy of anti-inflammatory therapy for patients with coronary artery disease (CAD) is still controversial. Therefore, this study aims to evaluate the safety and efficacy of anti-inflammatory drugs in patients with CAD.
Method
We conducted this systematic review and meta-analysis of randomized controlled trials about the safety and efficacy of anti-inflammatory therapy in patients with CAD. The relevant randomized controlled trials were included by searching PubMed, EMBASE, web of science and Cochrane Library database. The primary outcome was the composite outcome of cardiovascular death, myocardial infarction (MI), and stroke. The secondary outcomes included MI, coronary revascularization, cardiovascular death, all-cause death and stroke. The relative risk (RR) and 95% confidence intervals (CI) for outcome events were calculated by the fixed effects model, and trial sequential analysis was applied to assess the results.
Result
A total of ten randomized controlled trials and 61065 patients with CAD was included (32227 patients receiving the anti-inflammatory therapy, 28937 patients without receiving the anti-inflammatory therapy). Compared with patients without receiving the anti-inflammatory therapy, the anti-inflammatory therapy significantly reduced the incidence of the primary outcome in patients with CAD (RR 0.93, 0.89-0.98, P=0.006). In addition, the anti-inflammatory therapy can also reduce the risk of MI (RR 0.90, 0.84-0.96, P=0.002) and coronary revascularization (RR 0.74, 0.66-0.84, P <0.00001) remarkably. However, there was no significant difference in the incidence of cardiovascular death (RR 0.93, 0.85-1.02, P=0.12), all-cause death (RR 1.00, 0.93-1.06, P=0.88) and stroke (RR 0.94, 0.83-1.07, P=0.36) between two groups.
Conclusions
The anti-inflammatory therapy can reduce the incidence of primary outcome in patients with CAD, especially the risk of MI and coronary revascularization (Registered by PROSPERO, CRD 42020220315).