bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical coherence tomography characterization of spontaneous recanalized coronary thrombus – Single center experience
Authors: Gupta Ankit , Rao K Raghavendra , Reddy S Sreenivas , Kashyap Jeet Ram , Kadiyala Vikas , Kaur Jaspreet , Dash Debabrata , Kumar Suraj , Dev Munish
Published: January 2023

Introduction: Recanalized thrombus is an under diagnosed clinical entity. Aim was to investigate the utility of optical coherence tomography (OCT) in identifying spontaneously recanalized thrombi (SRCT) for management in clinical practice. Methods: This was a retrospective study analyzing 2678 coronary angiograms over a 4-year period which included intravascular imaging guidance in 75.8% of the percutaneous coronary interventions (PCI). Angiographic suspicion of SRCT has hazy appearance seen in 34 patients. Results: Eight patients (7 males and 1 female) were confirmed with SRCT on OCT and two underwent intravascular ultrasound (IVUS). Median age was 52 years (range 33-67 years). Based on clinical symptoms, diagnosis was STEMI-2, NSTEMI-1, unstable angina-3 and chronic stable angina-2. Angiographic patterns were veiled/hazy appearances in 3; braided in 2; pseudo dissection in 2; and near occlusion in 1 patient. OCT findings displayed multiple small cavities, signal-rich with high backscattering and thin septa with smooth inner borders dividing the lumen and intercommunications. Presence of multiple holes conferred typical "Swiss cheese" or ‘lotus root’ like appearance, characteristic of recanalized thrombi. SRCT lesion length was (median interquartile ranges [IQR], 16.5[12.07-21.5] mm) and minimal luminal area (median [IQR], 1.77 [0.93-3.26] mm2 ) with significant stenosis (median [IQR], 74.0[67.0-81.0] %). Minimum/maximum number of channels were (median [IQR], 2.0[2.0-2.0]) and (median [IQR], 4.50[4.0-6.75]) respectively. Lipid rich plaque was predominant. IVUS demonstrated echo-lucent channels with small cavities. All but one patient underwent PCI. Conclusion: Intravascular imaging by OCT delineates the characteristics of recanalized thrombi and distinguishes ambiguous lesions. Majority of the lesions involving SRCT were significant both symptomatic and stenosis severity wise on OCT requiring PCI.
The correlation between speckle-tracking echocardiography and coronary angiography in suspected coronary artery disease with normal left ventricular function
Authors: Yadav Krishan , Prajapati Jayesh , Singh Gaurav , Patel Iva , Karre Ajay , Bansal Pradeep Kumar , Garhwal Vicky
Published: January 2023

Introduction: Our study objects to determine the diagnostic accuracy of two-dimensional speckle tracking echocardiography (2DSTE) in predicting presence and severity of coronary artery disease (CAD). Methods: Patients with stable angina pectoris with normal left ventricular function (>50%) undergoing coronary angiography were enrolled and subjected to speckle tracking echocardiography. Global longitudinal peak systolic strain was measured and correlated to the results of coronary angiography for each patient. Results: Number of male (P=0.001), diabetes (P=0.01) and smoking (P=0.01) patients were significantly higher in the CAD group compared to non-CAD patients. Global longitudinal peak systolic strain (GLPSS) was significantly (P=0.0001) lower in CAD patients in comparison to non- CAD patients. GLPSS showed significantly lower in patients with Syntax score (SS)≥22 in comparison to SS<22. Cut-off value -19 for GLPSS could be used to predict the presence of significant CAD with 80.6% sensitivity and 76.5% specificity (area under curve (AUC) -0.83, P=0.0001). The mean GLPSS value decreased as the number of diseased coronary vessels increased (P=0.0001). The optimal cut-off value of -16 GLPSS with a sensitivity of 76.7% and specificity of 83.3% [AUC 0.84, P<0.0001] was found significant to predict CAD severity. Multivariate regression of GLPSS and another risk factor for predicting significant CAD, GLPSS showed OR=1.55 (CI-1.36-1.76) P=0.0001 for predicting the presence of CAD. Conclusion: 2DSTE can be used as a non-invasive screening test in predicting presence, extent and severity of significant CAD patients with suspected stable angina pectoris.
Upward spontaneous migration of ventriculoperitoneal shunt into the heart: A case report summary
Authors: Ghaffari Shamsi , Hashemzadeh Khosro , Samadi Mahmood , Molaei Akbar , Sadeghi Sahar , Jamei Khosroshahi Ahmad
Published: January 2023

A male infant with a history of ventriculoperitoneal (VP) implantation due to congenital hydrocephalus presented with fever and lethargy at the age of 8 month-old. Pericardial effusion was detected in transthoracic echocardiography, and he underwent pericardial window operation and was discharged in a stable condition. At 11 months of age, he presented again with fever, lethargy, recurrent vomiting, and respiratory distress. In both plain chest radiography and transthoracic echocardiography, VP shunt migration to the heart cavity was observed. The VP shunt had entered into the right ventricle after perforating the diaphragm and pericardium. The patient underwent open-heart surgery due to vegetation at the tip of the VP shunt inside the right heart. Vegetation was removed and the tip of the shunt was returned to the peritoneal cavity. Two weeks after discharge, the patient presented again with symptoms of tachypnea and lethargy. The imaging revealed the entry of the VP shunt about two centimeters into the anterior mediastinum. The patient was transferred to the operation room and the VP shunt was shortened and re-inserted into the peritoneal cavity. Antibiotic treatment was continued for six weeks and the patient was discharged in stable condition. In follow-up visits after two years, the VP shunt functioned well and no particular complication was observed. This case demonstrates that in patients with VP shunt implantation presenting with pulmonary and cardiac symptoms such as respiratory distress, pericardial effusion, and cardiac tamponade after VP shunt implantation, the possibility of VP shunt catheter migration to the mediastinal cavity should be considered.
The relationship between H2FPEF score and contrast induced nephropathy in patients with ST elevation myocardial infarction
Authors: Ceylan Ufuk Sadik , Yıldırım Ersin
Published: January 2023

Introduction: In the present study, we aimed to investigate the relationship between H2FPEF score and Contrast Induced Nephropathy (CIN) in patients with myocardial infarction with ST segment elevation (STEMI). Methods: A total of 355 patients who had been diagnosed with ST elevation-myocardial infarction and undergone primary coronary angioplasty were retrospectively included in the study. The patients were divided into two groups according to the presence of CIN and these groups were compared in terms of baseline characteristics and laboratory findings. The H2FPEF score was calculated for each patient on admission and later compared between the groups. Results: The distribution of the study population was as following: 63 (17.7%) CIN (+) and 292 (82.2%) CIN (-). In CIN (+) group, the mean H2FPEF Score (2.00±1.60 vs 1.25±1.26, P<0.001) was significantly higher than the CIN (-) group. H2FPEF Score (OR: 1.25, 95%CI: 1.01-1.55), and mean age (OR: 1.03, 95%CI: 1.00-1.06) were found to be independently associated with CIN development. Conclusion: H2FPEF score is an independent predictor of CIN development in patients with acute STEMI. It is easily calculated and and may be used to estimate the CIN in STEMI patients.
Dyspnea in pregnancy might be related to the incomplete physiological adaptation of the heart
Authors: Mostafavi Atoosa , Feizian Mona , Fotook Kiaei Seyedeh Zahra , Tabatabaei Seyed Abdolhussein
Published: January 2023

Introduction: Dyspnea is a common complaint in pregnant women with no cardiac and pulmonary diseases. We aimed to assess whether physiological dyspnea of pregnancy was correlated with subtle changes in ventricular systolic and diastolic function. Methods: This cross-sectional study enrolled 40 healthy pregnant women in their second and third trimesters with no complaints of dyspnea and 40 healthy pregnant women in the same trimesters with a complaint of dyspnea. Parameters of echocardiography were compared between the 2 groups. Results: Global left ventricular ejection fraction (59.65±6.44 and 58.49±4.95 P=0.418 in patients without and with dyspnea respectively), and global longitudinal strain were not significantly different (18.72±2.90 and 18.94±3.07, P=0.57 in the same order). Global circumferential strain(GCS)was lower in patients with dyspnea. ( 20.19±4.86 vs 22.61±4.69 ,P=0.03). Systolic volume (33.17±8.94 vs 32.63±8.09) and diastolic volume(80.75±18.73 vs 78.37±16.63) and left ventricular end-diastolic diameter(47.5±4.24 vs 46.23±3.21)were not different (P=0.784, 0.560 and 0.146 respectively) .Left ventricular end-systolic diameter was significantly lower in the case group (32.52±4.66 vs 29.92±4.05, P=0.011). Left atrial area index in the patients with dyspnea was lower.( 8.13±1.42 vs 8.94±1.4, P=0.014) . Other findings were a high E/E’ and high pulmonary artery pressure in the patients with dyspnea. Conclusion: Dyspnea in pregnant women can be a consequence of incomplete physiological adaptation to volume overload in pregnancy. Lower systolic and diastolic diameters of the left ventricle, left atrial area, and left atrial index may lead to increased filling pressure, manifested by a higher E/E’ ratio and pulmonary artery pressure.
Predictive value of C-reactive protein/albumin ratio for no-reflow in patients with non-ST-elevation myocardial infarction
Authors: Rodi Tosu Aydın , Çinar Tufan , Kalyoncuoğlu Muhsin , Biter Halil İbrahim , Çakal Sinem , Çakal Beytullah , Selçuk Murat , Belen Erdal , Mustafa Can Mehmet
Published: January 2023

Introduction: The focus of this research was to explore the link between CRP (C-reactive protein) /albumin ratio (CAR), a novel inflammatory response marker, and no-reflow (NR) phenomena in non-ST elevation myocardial infarction (non-STEMI) patients during percutaneous coronary intervention (PCI). Methods: The current study recruited 209 non-STEMI participants who underwent PCI. The patients were divided into two groups based on their post-intervention Thrombolysis in Myocardial Infarction (TIMI) flow grade; those with and without NR. Results: In all, 30 non-STEMI patients (6.9%) had NR after PCI. CAR values were substantially greater in the NR group. The CAR was identified to be a determinant of the NR (OR: 1.250, 95% CI: 1.033-1.513, P=0.02), although CRP and albumin were not independently related with NR in the multivariate analysis. In our investigation, low density lipoprotein-cholesterol levels and high thrombus burden were also predictors of the occurrence of NR. According to receiver operating characteristic curve evaluation, the optimal value of CAR was>1.4 with 60% sensitivity and 47% specificity in detecting NR in non-STEMI patients following PCI. Conclusion: To the best of knowledge, this is the first investigation to demonstrate that the CAR, a new and useful inflammatory marker, can be utilized as a predictor of NR in patients with non-STEMI prior to PCI.
Effects of angiotensin receptor blockers (ARBs) on clinical outcomes of patients with hypertension and COVID-19: A 7-month follow-up cohort study
Authors: Hadadi Azar , Kazemian Sina , Shafie Mahan , Ahmadi Arezoo , Soleimani Abbas , Ashraf Haleh
Published: January 2023

Introduction: Since the coronavirus disease 2019 (COVID-19) pandemic, the use of angiotensin II receptor blockers (ARBs) in hypertensive patients with COVID-19 has been controversial. Following our previous study, after one year, we intended to extend our sample size and results to investigate the effects of ARBs with both in-hospital outcomes and 7-month follow-up results in patients with COVID-19. Methods: Patients with a diagnosis of COVID-19 who were admitted to Sina Hospital, Tehran, Iran, from February to October 2020 participated in this follow-up cohort study. The COVID-19 diagnosis was based on a positive polymerase chain reaction test or chest computed tomography scan according to guidelines. Patients were followed for disease severity, incurring in-hospital mortality, complications, and 7-month all-cause mortality. Results: We evaluated 1413 patients with COVID-19 in this study. After excluding 124 patients, 1289 including 561(43.5%) hypertensive patients, entered the analysis. During the study, 875(67.9%) severe disease, 227(17.6%) in-hospital mortality, and 307(23.8%) 7-month all-cause mortality were observed. After adjusting for possible confounders, ARB was not associated with severity, in-hospital and 7-month all-cause mortality, and in-hospital complications except for acute kidney injury. Discontinuation of ARBs was significantly associated with higher in-hospital mortality and 7-month all-cause mortality (both P values<0.006). We observed a better 7-month outcome in those who continued their ARBs after discharge. Conclusion: The results of this study, along with the previous studies, provide reassurance that taking ARBs is not associated with the risk of mortality, complications, and poorer outcomes in hypertensive COVID-19 patients after adjustment for possible confounders.
The Correlation between Orthodontic Treatment Need and Psychosocial Impact of Dental Aesthetics among Patients Seeking Orthodontic Treatment
Authors: Pouralimardan Mohammadreza , Karimi Afshar Mehrnaz , Karimi Afshar Marzieh
Published: January 2023

Background: The influence of orthodontic treatment on self-confidence and quality of life is a major reason for patients to seek treatment. This study was designed to assess the relationship between orthodontic treatment need and psychosocial impact of dental aesthetics in patients seeking orthodontic treatment. Methods: This descriptive analytical cross-sectional study was performed on 165 patients referred to orthodontic clinics in Kerman to start treatment. Patients were selected by census method to reach the specified sample size. The data collection tools included 3 forms: demographic information form, Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) and a form for recording information obtained from clinical examination to determine orthodontic treatment need based on Index of Orthodontic Treatment Need (IOTN). Data analysis was performed through SPSS 22 and using t test, ANOVA, and linear regression at a significance level of 0.05. Results: The educational level of subjects and their parents and economic status showed no significant relationship with total PIDAQ score and any of its domains (P>0.05). In psychological impact domain, women’s score was significantly higher (P=0.016) and there was a significant relationship between the treatment need based on aesthetic component (AC) and the domains of dental self-confidence (P=0.003), social impact (P=0.049) and psychological impact (P=0.066), as well as the total score of questionnaire (P=0.012). Treatment need based on dental health component had no statistically significant relationship with PIDAQ score (P>0.05). Conclusion: AC of IOTN had significant relationship with dental self-confidence, social impact and psychological impact as well as the total score of PIDAQ. In orthodontic treatments, in addition to malocclusion, the psychological aspects should also be considered.
Biological Functions of Nitric Oxide in the Brain and Brain Stem
Authors: Rezaei Zahra , Hajizadeh Sohrab , Piri Zahra
Published: January 2023

Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain.
Effects of Purslane Supplementation on Blood Lipid Profile: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Talaei Behrouz , Ravari Seyed Sina , Salavatizadeh Marieh
Published: January 2023

Background: Blood lipid profiles are known as one of the most important factors in health disorders such as obesity and diabetes, which mostly end in cardiovascular diseases (CVDs) such as coronary heart disease (CHD). Purslane, as an edible herbal plant has shown to have beneficial components for dyslipidemia treatment. This study aimed to evaluate the effects of purslane supplementation on blood lipid profiles in the adult population. Methods: The terms Portulaca, Portulaca, Portulaca oleracea, and Purslane together with lipid profile ingredients including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were searched in the following databases until 30 October 2020: PubMed, MEDLINE, Scopus, EMBASE, Science Direct, and SID. A meta-analysis was conducted with eight randomized controlled trials (RCTs) on 444 patients using the STATA software version 14. Results: Eight eligible studies on 444 patients were identified for the present study. The purslane supplementation caused significant reduction in TG (-18.55 mg/dL, 95% CI [-31.712, -5.388]), TC (-8.43 mg/dL; 95% CI [-14.99, -1.87]), and LDL-C (-6.45 mg/dL, 95% CI [-11.13, -1.77]); however, no significant effect was observed on HDL-C (1.28 mg/dL, 95% CI [-0.56, 2.93], P=0.170). Conclusion: Our results suggested that purslane supplementation could reduce TG, TC, and LDL-C. However, no significant effect was observed on HDL-C. Keywords: Portulaca, C
Educational Tips for Students and Physiology Instructors Regarding Reabsorption of Kidney’s Proximal Tubule and Autoregulation: Different Perspectives of Medical and Postgraduate Students
Authors: Saberi Shadan , Askaripour Majid , Afzali Hamideh , Khaksari Mohammad
Published: January 2023

The authors opinions in physiology books are different on some issues, and this mixes up the readers. The purpose of this article is to clarify the differences between two examples in renal physiology (the autoregulation and the reabsorption of the materials in the proximal tubule) to help better understand; therefore, this paper is especially beneficial for medical students. The latest editions of several physiology books are used in this study including Brenner and Rector›s "The Kidney", Seldin and Giebisch’s "The Kidney Physiology and Pathophysiology", Koeppen Stanton›s "Renal Physiology", Vander’s "Renal Physiology", Boron’s "Medical Physiology", Ganong’s "Review of Medical Physiology", Rose’s "Clinical Physiology of Acid-Base and Electrolyte Disorders", "Renal Pathophysiology: the Essentials" by Rennke and Denker, "Color Atlas of Physiology", "Renal Physiology: a Clinical Approach", and "Medical Physiology" by Guyton. It is concluded that the two above-said methods, in general, adopt similar approaches. However, there are some differences in terms of details that are explained and clarified in this study.
Serum Progesterone Concentration and Ongoing Pregnancy Rate in Frozen-Thawed Embryo Transfers with Intramuscular Plus Vaginal Progesterone Administration for Endometrial Preparation
Authors: Mehrafza Marzieh , Raoufi Azadeh , Zare Yousefi Tahereh , Hosseinzadeh Elmira , Samadnia Sajedeh , Tamimi Amirhossein , Hosseini Ahmad
Published: January 2023

Background: Insufficient serum progesterone level in the implantation phase may reduce the rate of pregnancy during freeze embryo transfer (FET) cycles. The present study aimed to evaluate the impact of FET day serum progesterone level on pregnancy outcomes in patients receiving intramuscular plus vaginal progesterone administration for endometrial preparation. Methods: Based on serum progesterone level on FET day, patients were divided into four quartiles: first (<25%), second (26–50%), third (51%–75%), and fourth (>75%). There was no significant difference among groups in basal characteristics. Results: No statistically significant difference was seen among groups concerning the mean number of retrieved and mature oocytes, embryos transferred, and endometrial thickness (EnT). The rate of implantation (P=0.5), biochemical (P=0.75), clinical (P=0.54), and ongoing pregnancy (P=0.5) were not associated with serum progesterone level on embryo transfer day. Conclusion: We found that there is no association between serum progesterone level on ET day and pregnancy outcome during FET cycles. It seems that combination therapy using intramuscular and vaginal progesterone, keeps the serum progesterone on ET day high enough that eliminates the need for serum progesterone measurement.
Seronegative spondyloarthropathy (reactive arthritis) fourteen days following E. coli UTI: Case report
Authors: Padda Inderbir , Bhatt Rajat , Mathew Glady , Malhi Gurnaaz , Hans Manpreet
Published: January 2023

Reactive arthritis (ReA) is a post-infectious autoimmune condition classified as a seronegative spondyloarthritis (SpA). The current case report presents a 30-year-old female returned for follow-up visits after an acute onset of back pain that progressed to joint swelling and tenderness in both knees, and excruciating pain in her heels and the bottom of her feet four weeks ago. Two weeks prior to the onset of symptoms, the patient was treated for a urinary tract infection (UTI). Due to the symptoms and the inability to ambulate caused by feet pain, the patient was required to admit to a hospital for further evaluation. This case report depicts a unique presentation of ReA following UTI, and the discussion section aiding healthcare professionals in the diagnosis and management of ReA and patient education on ReA and disease course.
Shape memory polymers in osteochondral tissue engineering
Authors: Saghati Sepideh , Rahbarghazi Reza , Fathi Karkan Sonia , Nazifkerdar Sajed , Khoshfetrat Ali Baradar , Tayefi Nasrabadi Hamid
Published: January 2023

Bone and cartilage injuries are significantly increasing with population aging. Tissue engineering is considered an alternative and promising approach for alleviating osteochondral tissue injuries along with available therapeutic modalities. 3D- and 4D-printing fabrication protocols have been used to facilitate the production of bone/cartilage scaffolds that are similar to bone and cartilage microenvironments. In this regard, advanced biomaterials, including smart polymers and stimuli-responsive polymers are the first essential elements for improved bone/cartilage regeneration. Shape-memory polymers, are stimuli-responsive materials and are available in permanent and temporary structures. The application of shape-memory scaffolds can lead to providing in vivo-like conditions and improve cell bioactivity and phenotype acquisition. In this review article, we tried to highlight stimuli-responsive polymers and their application in osteochondral tissue engineering.
Posterior reversible encephalopathic syndrome in systemic lupus erythematous: A case report
Authors: Hosseini Samaneh
Published: January 2023

Posterior reversible encephalopathy syndrome (PRES) implies to a reversible subcortical vasogenic brain edema, which leads to some acute neurological symptoms. PRES occurs usually in the setting of renal failure, blood pressure fluctuations, cytotoxic drugs, autoimmune disorders, and pre-eclampsia or eclampsia.This is a 40 year old female patient with history of systemic lupus erythematous (SLE) from twenty years ago, admitted to our neurology ward due to severe and refractory headache with multiple convulsive events.Brain MRI showed vasogenic brain edema in occipito-parieto-frontal lobes white matter compatible with PRES. Treatment is omitting of the etiology, but in these patients, discontinuation of immunosuppressive drugs is not possible and probably intravenous methylprednisolone pulse is a good treatment option especially in patient without response to aggressive control of blood pressure.
Assessment of multiple-choice questions by item analysis for medical students’ examinations
Authors: Nojomi Marzieh , Mahmoudi Maryam
Published: January 2023

Background: Multiple-choice questions (MCQs) are a common assessment method, and it is crucial to design them carefully. Therefore, this study aimed to determine the item analysis of MCQ exams in clerkship tests for general medicine students. Methods: Following a cross-sectional study, a total of 1202 MCQs designed for fourth-year clerkship medical students in the second semester of 2019 were analyzed. Difficulty and discrimination indices of student scores and taxonomy levels were then computed. Furthermore, the prepared standard structural Millman checklist was utilized. Results: Of the 1202 MCQs, according to difficulty indices, most questions (666) were considered acceptable (55.39%). In terms of the discrimination index (DI), 530 (44.09%) questions had an average discrimination coefficient. Additionally, 215 (17.88%) had a negative or poor DI and required revision or elimination from the tests bank. Of the 1202 MCQs, 669 (50.7 %) were designed at a lower cognitive level (taxonomy I), 174 (14.5 %) belonged to taxonomy II, and 419 (34.8%) of the questions had taxonomy III. Moreover, according to the structural flaws of the Millman checklist, the most common structural flaw was a lack of negative choices for Stems 1127 (93.8 %), while vertical options 376 (31.3%) were the least common. Conclusion: Based on the results, it is recommended that easy questions and negative/poor DI of items, a high level of Bloom’s taxonomy type I, and questions with unstructured flaws be reviewed and reconstructed to improve the quality of the question banks. Holding training courses on designing test questions could effectively improve the quality of the questions.
Evaluation of the groundwater quality index (GWQI) and the human health risk (HHR) on fluoride concentration in Namakkal district, South India
Authors: Karuppaiah Sankar , Duraisamy Shanthi , Kaliyan Kalaivanan
Published: January 2023

This research aims to determine the health consequences of fluoride contamination of groundwater in the Namakkal region in south India using the groundwater quality index (GWQI). Study area latitude and longitude: 11° 00' and 11° 30' in the north, and 77° 45' and 78° 15' in the east. Statewide, it is among the largest districts in the state. The study region occupies an area of 3406.37 km2. The geology of the studied area is mainly based on the Archaean crystalline and metamorphic complex. The district's major aquifer systems are composed of crystalline rocks that are weathered and fractured and of colluvial deposits.  Alluvium and colluvium are examples of porous formations in the cross-section. Only the main river channels have alluvial deposits. The phreatic properties of groundwater Depending on the topography, these aquifers may reach 5 m saturation thickness. Groundwater samples were obtained from 58 bore well sites across the study area during the North-East Monsoon (NEM) of 2015. pH concentrations in suitable drinking water regions during the seasons assist in limiting the availability of groundwater for drinking purposes. TDS are an important factor in determining water suitability for various purposes. The groundwater sample in the study area shows cation domination in ascending order of Na+ > Ca2+ > Mg2+ > K+ due to the dissolution of aquifer minerals in rainfall in the study area. In the NEM seasons, rock dominance and anthropogenic contributions to higher Na+ > Mg2+ > Ca2+ > K+ values. Fluoride concentration differentiates into three groups such as < 0.5 indicates low risk, 0.5 to 1.5 indicates moderate risk, and > 1.5 means high risk. More than 2 fluoride implies very high risk, whereas fluoride in the range of 1.5 to 2.24 suggests a very high risk. The appraisal of non-carcinogenic risk was done to stress the health issues that succeed due to the intake and dermal contact of drinking water in the Namakkal district. The percentage of risk HQ >1 shows that 48 men groundwater samples, followed by 46 groundwater samples women and 30 groundwater samples children, constitute possible health hazards. Overall, health risk estimation results showed that all the groundwater samples have surpassed the permissible limit of HQ <1 for children.
Implementation of the Fuzzy Tsukamoto Method for Office Stationery Estimation Stock System
Authors: Rukmana Tedy , Fajri Hersanto , Widhyaestoeti Dahlia
Published: January 2023

Information technology supports the company's operational activities in recording incoming goods, outgoing goods, and existing inventory. PT. Mitraniaga Distribusindo is a company engaged in food distribution, which includes supporting aspects for smooth operations, such as stock availability of office stationery. The Tsukamoto fuzzy method aims to calculate the estimated stock of office stationery needed in the future to provide recommendations for deciding the estimated stock of office stationery. The estimated target variable is more numerical, with models built using complete records providing the variable value of the target as a predictive value. Testing the accuracy of the calculation results of the office stationery stock estimation system was conducted using the Root Mean Squared Error (RMSE) to get a value of 5.9 so that the decisions obtained are more precise. In application development, using the waterfall model, which provides a sequential or sequential software life flow approach starting from design analysis, coding, and up to application testing using black box testing that is produced, each test form produces an appropriate status, according to the expected results.
The Economic Impact of Cryptocurrencies in Indonesia
Authors: Rahardja Untung
Published: January 2023

In this era of global economic development, especially in Indonesia, it is inseparable from elements of high technology such as information. The development of information technology considers all fields, including the financial sector. Cryptocurrency, often called virtual/digital currency, results from the evolution of financial technology. Digital currency is widely used as a payment method on the Internet. This currency was created to provide convenience and security when making payments—with the included blockchain technology, reducing transaction costs. However, in this case, Bank Indonesia, the government has banned digital/cryptocurrency transactions because it hurts the Indonesian financial system, currency stability, and payment system. This study explains the impact of cryptocurrencies on the Indonesian economy and the government's attitude towards the technology it contains. In terms of the technology offered, cryptocurrency is an evolution of financial technology and will allow financial transactions to replace paper money with digital money in the future. The government will study more deeply the technology contained in cryptocurrencies. The policies made later will not prohibit the technology contained in cryptocurrencies. In general, it provides knowledge to gain a deeper understanding of cryptocurrencies. You will be able to do it.
The Effects of Early Childhood Science Education Problem-Based Learning (PBL) Classes on Self-Directed Learning Ability, Academic Self-Efficacy and Learning Motivation in Prospective Early Childhood Teachers
Authors:   Korean Society for  Holistic Convergence Education, Kim Da Rae
Published: January 2023

This purpose of this study is to investigate the effects of problem-based learning (PBL) classes on self-directed learning ability, academic self-efficacy, and learning motivation in prospective early childhood teachers. To this end, the effectiveness of PBL classes was analyzed by conducting pre- and post-experimental surveys on self-directed learning ability, academic self-efficacy, and learning motivation, involving 38 preliminary early childhood teachers who took a PBL-based early childhood science education course in the department of early childhood education at C University in the K region. To understand the effects of PBL classes on their self-directed learning ability, academic self-efficacy, and learning motivation according to the research questions, a paired t-test on the collected data were performed using the SPSS/PC (Windows 17.0) program. As a result of the study, the positive effectiveness of PBL classes was confirmed with statistically significant increases in all variables of self-directed learning ability, academic self-efficacy, and learning motivation in prospective early childhood teachers. These results can be used as basic data to find a way to be used in the field of teacher training as a teaching-learning method for strengthening the competence of pre-service early childhood teachers.
Ideas para una Educación Renovadora
Authors: Ianni Carol Elizabeth , Isea-Argüelles Josía Jeseff , Aldana-Zavala ulio Juvenal
Published: January 2023

Ideas renovadoras para la educación es un libro pensado, diseñado y redactado bajo una mirada a las necesidades actuales de introducir e implementar a la praxis docente herramientas útiles; partiendo de reflexiones temáticas actuales para del siglo XXI. Se trata de una recopilación y revisión bibliográfica contextualizada en los diferentes aportes teóricos que buscan dar respuesta a las exigencias de transformación educativa de esta era.
Case Study of the Use of Learner-Centered Assessment in the Math School of a Large University in the United States
Authors: Zheng Yi , Van Vliet Fern , Jin Jeong Im
Published: January 2023

This case study examined the current assessment practices in the math school of a large research university in the United States. After reviewing a sample of course syllabi offered in the spring 2021 semester, we descriptively summarized the use of 19 assessment methods in the school and examined the assessment patterns by subjects, grade levels, and class size. Our study found that traditional homework and written tests were the most frequently used assessments in the school, while the use of learner-centered assessments was rare. Among the 19 assessment methods, we found significantly different usage of quizzes, participation scores, and projects by various course characteristics. Our case study demonstrates the gap between the recommended and actual assessment practice in U.S. higher education. We call for more future research that explores strategies to effect changes and increase the use of learner-centered assessment in higher education institutions.
One but Not the Same: Non-Science Art in Science Education
Authors: Lee Hee-Sun , Price C. Aaron , Applebaum Lauren , Coleman Amber , DeWitt Jennifer , Miller Alexa , Moorman Meg , Smith Jeff , Steciuch Christian , Tanner Ann
Published: January 2023

This white paper describes outcomes from a conference about using non-science art in science education. Art and science are often combined for entertainment, education (STEAM) and inspirational value. However, in almost all cases the art is science-themed (scientific visualizations, science-inspired art, art about scientific topics, etc.). This conference asks the question “what about art for arts-sake?”. That is, what is the impact of non-scientific art in science education? Can non-science themed art be used to broaden perspectives about science? Can it cue people to think about science more and differently? The conference, held at the Museum of Science and Industry in Chicago with support from the National Science Foundation, assembled artists, art educators, education researchers and scientists to discuss the potential of these topics and ways to study them.
Citation databases to evaluate openness of research funded by public grants
Authors:   State Scientific and Technical Library Of Ukraine, German  National Library, Tsiura Marharyta , Tsybenko Iryna ,   State Scientific and Technical  Library of Ukraine
Published: January 2023

This study investigates current state of open access publications resulted from support of government funds in Ukraine and neighboring countries. We analyzed the coverage of different types of Open Access based on Scopus and Web of Science web interface classifications. We argued about Scopus and Web of Science feasibility to evaluate openness of scientific research on a national level.
On the use of social networks as a prediction market tool for improving the practice of evaluation scientific research
Authors:   S. I. Subbotin’ Institute of Geophysics of National Academy of Sciences of Ukraine, Dubovenko Yurii
Published: January 2023

The summarized results of a collective discussion at a scientific forum for a simulated case regarding the non-obvious disadvantage of the Hirsch index are described. It is the calculation of the ratio of citations between the author of an idea who has one publication and his disciples followers who developed its small details in numerous cross-referenced publications. Resulting from the discussion, the wording of the problem was clarified and set of little known to commons resources were identified which allow evaluate various aspects of the scientist’s contribution to the scientific output.
Open science: opportunity for Ukraine
Authors:   Lviv Polytechnic National University, Berezko Oleksandr
Published: January 2023

Open Science is a more transparent approach to the research process providing multiple advantages to its practitioners. Today the global switch toward Open Science is gaining momentum, and Ukraine has a unique chance to relaunch the domestic research system alike the switch to user-centered WWW (Web 2.0) in the mid-2000s.
“Open science”: contradictions and algorithms of implementation
Authors:   Kamianets-Podilskyi National Ivan Ohienko University, Franchuk Tetiana
Published: January 2023

The article presents the results of research that argue the need to work out the concept of “Open Science”, its practical realization based on balancing the demand for the results of scientific activity and their accessibility. This is realized through the development of constructive relationships between subjects of scientific activity, an innovative environment, an adequate information space (access to databases in their context).
Formation of open science competence at bogomolets nmu in the period of martial law
Authors:   Bogomolets National Medical University, Kucherenko Inna
Published: January 2023

This article presents the conditions for the formation of competence in liberal science at the National Medical University named after O.O. Bogomolets in the conditions of martial law.
Modern resources for the formation, systematization and unification of the conceptual and terminological apparatus
Authors:   Institute for  Digitalisation of Education of the NAES of Ukraine, Pinchuk Olga , Luparenko Liliia ,   Institute for Digitalisation of Education of  the NAES of Ukraine
Published: January 2023

Ukrainian education requires a professional digital encyclopedia containing scientifically reliable and modern interpretations of the terminology of pedagogy and psychology. Electronic encyclopedias provide 24/7 access to content, search functions, inclusion of multimedia content in articles. The developing of the “Ukrainian Electronic Encyclopedia of Education” will ensure the formation, systematization, unification, and up-to-date maintenance of educational terminology.
Vilna nauka: news aggregator of ukrainian science based on the example of world analogues
Authors:   National Technical University of Ukraine  “Igor Sikorsky Kyiv Polytechnic Institute”, Kysil Veronika
Published: January 2023

The research analyzes the strengths and weaknesses of the world’s scientific news aggregators, their resource support. In addition, it was found that the independence of the scientific press is one of the main criteria for the success of the aggregator and compliance with journalistic ethics. The task of the research is to resolve the problematic issue of resource funding, when state funding of aggregators allows the authorities to control the process of information publication. In parallel with state funding, funds or crowdfunding platforms allow the aggregator to exist without political bias. On the other hand, public financing of science popularization platforms can lead to global questions about the existence of the aggregator as such due to the lack of necessary funding.
The influence of social network signals on the development of library web resources by search words
Authors:   The state scientific and technical library of Ukraine, Strunhar Artur , Artyuh Andrii ,   The state scientific and technical library of Ukraine
Published: January 2023

The relationship between social media and library web resources is deeper than it may seem at first glance, and the effective use of modern tools can improve the search output of a web resource, which in turn will allow the library to effectively perform its information management functions in the modern digital economy .
SOCIO-LABOR RELATIONS IN GLOBAL TURBULENCE: A VIEW THROUGH THE PRISM OF SOCIAL SECURITY
Authors: Poplavska Oksana
Published: January 2023

Introduction. Today's turbulence is constantly changing socio-labor relations, which is manifested in the spread of atypical forms of employment, narrowing of social security of workers, the formation of a new world division of labor, which ultimately affects the sustainability of development as a country, employee welfare. Such transformations proportionally change the level of social security of the country and workers, but the vector of these changes is not always aimed at improvement. Unfortunately, the existing theoretical and methodological approaches to assessing the condition of socio-labor relations do not allow to predict deeper changes and consequences for the further development of society, the country, so it is important to explore them through the prism of social security.
Purpose. The aim of the article is to study the transformations of socio-labor relations under the pressure of the new socio-economic reality (pandemic COVID-19) and the possibility of implementing their adaptive mechanisms to maintain a sufficient level of social security.
Method (methodology). The methodological basis of the study is formed by general scientific methods - analysis, generalization, theoretical foundations of the concepts of decent work, social responsibility and green economy. The assessment of socio-labor relations in the context of their ability to form the preconditions of social security was carried out according to the author's method, which allows to identify reference points for the emergence of risks and dangers. Analytical calculations were performed using statistical methods, using official statistical reports of international organizations, scientific developments of leading scientists in the field of social security and the essence of social and labor relations.
Results. The connection between the development of social and labor relations and the formation of preconditions for social security is revealed. Calculated objective indicators of socio-labor relations that directly affect the level of social security, such as financial well-being of employees, the potential for human capital development (wage potential) and the risks of job loss, as well as subjective indicators - life satisfaction, mental health and confidence in the future (development, income expectations). It was found that the social partners in Ukraine have not been able to achieve a high level of collaboration, so the current model of socio-labor relations does not fully provide sufficient social security for workers and the country.
ECONOMICS OF INTELLIGENCE IN THE CONTEXT OF A TRANSDISCIPLINARY APPROACH
Authors: Krykhovets-Khomyak Lilia
Published: January 2023

Introduction. The versatility of the components of the human intelligence system, applied aspects of the mechanisms of formation of activity behavior of the individual in terms of its economic choices are considered.
Research methods. The basis of methodological research is the methods of empirical and theoretical research: the use of a systematic approach in the analysis of theoretical foundations and practice in the field of behavioral economics. To achieve this goal, the following research methods were used: system and logical analysis, the method of analogies, systematization and generalization.
Results. The versatility of the essence of the category "human intelligence" is investigated. The trinity model of human intelligence, which determines the influences, individual and collective life priorities, choices, including economic ones, is examined in more detail. The neural and psychological aspects of the brain and the tools that influence our human beliefs, desires, needs, financial choices, shape actions and personal economic behavior in general are considered.
The essential characteristic of the definition of the economy of intelligence is given. The role and essence of human intelligence in the context of modern research of the transdisciplinary approach to economic choices of behavior of subjects in the conditions of interaction are substantiated.
Perspectives. Further research on various aspects of human intelligence is important in the context of election economics, financial thinking, and entrepreneurship, in terms of a qualitatively new institutional plane of development of relations between educational services in the current realities of socio-economic development and economic reset at the national, regional and local levels..