bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases
Authors: Lessigiarska Iglika , Peng Yunhui , Tsakovska Ivanka , Alov Petko , Lagarde Nathalie , Jereva Dessislava , Villoutreix Bruno O. , Nicot Arnaud B. , Pajeva Ilza , Pencheva Tania , Miteva Maria A.
Published: October 2021

The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods. An in-house library of natural ligands (hormones, neurotransmitters, plant-derived compounds and their metabolites) reported to interact with SULTs was created. Their chemical structures and properties were compared to those of compounds of non-natural (synthetic) origin, known to interact with SULTs. The natural ligands interacting with SULTs were further compared to other natural products for which interactions with SULTs were not known. Various descriptors of the molecular structures were calculated and analyzed. Statistical methods (ANOVA, PCA, and clustering) were used to explore the chemical space of the studied compounds. Similarity search between the compounds in the different groups was performed with the ROCS software. The interactions with SULTs were additionally analyzed by docking into different experimental and modeled conformations of SULT1A1. Natural products with potentially strong interactions with SULTs were outlined. Our results contribute to a better understanding of chemical space and interactions of natural compounds with SULT enzymes and help to outline new potential ligands of these enzymes.
New Steroidal Saponins Isolated from the Rhizomes of Paris mairei
Authors: Liu Yang , Qiu Pengcheng , Wang Minchang , Lu Yunyang , He Hao , Tang Haifeng , Zhang Bang-Le
Published: October 2021

The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A–E (1–5), along with five known steroidal saponins 6–10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
Comparison of β-Glucan Content in Milled Rice, Rice Husk and Rice Bran from Rice Cultivars Grown in Different Locations of Thailand and the Relationship between β-Glucan and Amylose Contents
Authors: Phuwadolpaisarn Pattraporn
Published: October 2021

β-glucan is a dietary fiber that is beneficial to human health, and its content varies according to its different parts, type of cereal grain, and growing environment. In this study, the β-glucan of milled rice, rice husk, and rice bran fractions, as well as the amylose content of milled rice fraction, from 38 selected rice-paddy grains from six regions of Thailand were quantitatively determined. The milled rice of the Sakon Nakhon (SN) cultivar grown in the northeast contained the highest β-glucan content (0.88 ± 0.03%), followed by the milled rice of the Jow Khao Chiangmai (JKC) cultivar (0.71 ± 0.03%) and rice bran of the Sew Mae Jan (SMJ) cultivar (0.67 ± 0.03%) grown in the north. The results reveal that the rice cultivars from each region showing variation in the β-glucan level in each fraction, which is mainly found in milled rice and rice bran, are similar to those found in other cereal grains, although low amounts are found in the husk. The amylose and β-glucan contents in the milled rice fraction showed a strong negative correlation (r = −0.805; p < 0.0001). This new information about the β-glucan content of Thai rice cultivars could be used for the development of cereal-based functional food.
Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis
Authors: Larenkov Anton A. , Makichyan Artur G. , Iatsenko Vladimir N.
Published: October 2021

Today, 44Sc is an attractive radionuclide for molecular imaging with PET. In this work, we evaluated a 44Ti/44Sc radionuclide generator based on TEVA resin as a source of 44Sc. The generator prototype (5 MBq) exhibits high 44Ti retention and stable yield of 44Sc (91 ± 6 %) in 1 mL of eluate (20 bed volumes, eluent—0.1 M oxalic acid/0.2 M HCl) during one year of monitoring (more than 120 elutions). The breakthrough of 44Ti did not exceed 1.5 × 10−5% (average value was 6.5 × 10−6%). Post-processing of the eluate for further use in radiopharmaceutical synthesis was proposed. The post-processing procedure using a combination of Presep® PolyChelate and TK221 resins made it possible to obtain 44Sc-radioconjugates with high labeling yield (≥95%) while using small precursor amounts (5 nmol). The proposed method takes no more than 15 min and provides ≥90% yield relative to the 44Sc activity eluted from the generator. The labeling efficiency was demonstrated on the example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis. Some superiority of PSMA-I&T over PSMA-617 in terms of 44Sc labeling efficiency was demonstrated (likely due to presence of DOTAGA chelator in the precursor structure). It was also shown that microwave heating of the reaction mixture considerably shortened the reaction time and improved radiolabeling yield and reproducibility of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis.
Antioxidant Properties of Hydrogen Gas Attenuates Oxidative Stress in Airway Epithelial Cells
Authors: You In-Soo , Sharma Subham , Fadriquela Ailyn , Bajgai Johny , Thi Thuy Trinh , Rahman Md. Habibur , Sung Jaeyong , Kwon Hwang-Un , Lee So-Yeon , Kim Cheol-Su , Lee Kyu-Jae
Published: October 2021

Oxidative stress plays a crucial role in the development of airway diseases. Recently, hydrogen (H2) gas has been explored for its antioxidant properties. This study investigated the role of H2 gas in oxidative stress-induced alveolar and bronchial airway injury, where A549 and NCI-H292 cells were stimulated with hydrogen peroxide (H2O2) and lipopolysaccharide (LPS) in vitro. Results show that time-dependent administration of 2% H2 gas recovered the cells from oxidative stress. Various indicators including reactive oxygen species (ROS), nitric oxide (NO), antioxidant enzymes (catalase, glutathione peroxidase), intracellular calcium, and mitogen-activated protein kinase (MAPK) signaling pathway were examined to analyze the redox profile. The viability of A549 and NCI-H292 cells and the activity of antioxidant enzymes were reduced following induction by H2O2 and LPS but were later recovered using H2 gas. Additionally, the levels of oxidative stress markers, including ROS and NO, were elevated upon induction but were attenuated after treatment with H2 gas. Furthermore, H2 gas suppressed oxidative stress-induced MAPK activation and maintained calcium homeostasis. This study suggests that H2 gas can rescue airway epithelial cells from H2O2 and LPS-induced oxidative stress and may be a potential intervention for airway diseases.
Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
Authors: Yurasakpong Laphatrada , Nantasenamat Chanin , Nobsathian Saksit , Chaithirayanon Kulathida , Apisawetakan Somjai
Published: October 2021

Betulinic acid (BA) is a pentacyclic triterpene usually isolated from botanical sources. Numerous studies have reported the inhibitory effect of BA against human colorectal cancer cells (CRC). However, its effect on the expression of the molecular chaperone HSPA is unclear. The aim of this research is to investigate the anti-cancer activities of BA purified from Piper retrofractum and study its effect on the expression of HSPA in colorectal cancer HCT116 and SW480 cells. The viability of both cancer cells was reduced after they were treated with an increasing dosage of BA. Flow cytometry assay revealed that levels of cell apoptosis significantly increased after incubation with BA in both cancer cells. Pro-apoptotic markers including Bax, cleaved-caspase-3 and cleaved-caspase-9 were increased while anti-apoptotic marker Bcl-2 was decreased after BA treatment. Western blot also showed that the expression of HSPA fluctuated upon BA treatment, whereby HSPA was increased at lower BA concentrations while at higher BA concentrations HSPA expression was decreased. Preliminary molecular docking assay showed that BA can bind to the nucleotide binding domain of the HSP70 at its ADP-bound state of the HSP70. Although further research is needed to comprehend the BA-HSPA interaction, our findings indicate that BA can be considered as potential candidate for the development of new treatment for colorectal cancer.
Natural Clay as a Low-Cost Adsorbent for Crystal Violet Dye Removal and Antimicrobial Activity
Authors: Alorabi Ali Q. , Hassan Mallick Shamshi , Alam Mohammad Mahboob , Zabin Sami A. , Alsenani Nawaf I. , Baghdadi Neazar Essam
Published: October 2021

This investigation aimed at evaluating the efficiency of micro and nanoclays as a low-cost material for the removal of crystal violet (CV) dye from an aqueous solution. The impacts of various factors (contact time, pH, adsorbent dosage, temperature, initial dye concentration) on the adsorption process have been taken into consideration. Six micro and nanoclay samples were obtained by treating clay materials collected from different locations in the Albaha region, Saudi Arabia. Out of the six tested micro and nanoclays materials, two (NCQ1 and NCQ3) were selected based on the highest adsorption efficiency for complete experimentation. The morphology and structure of the selected micro and nanoclay adsorbents were characterized by various techniques: SEM-EDX, FTIR, XRF, XRD, and ICP-MS. The XRF showed that the main oxides of both nanoclays were SiO2, Al2O3, Fe2O3, K2O, CaO, and MgO, and the rest were impurities. All the parameters affecting the adsorption of CV dye were optimized in a batch system, and the optimized working conditions were an equilibrium time of 120 min, a dose of 30 mg, a temperature of 25 °C, and an initial CV concentration of 400 mg/L. The equilibrium data were tested using nonlinear isotherm and kinetic models, which showed that the Freundlich isotherm and pseudo-second-order kinetics gave the best fit with the experimental data, indicating a physico-chemical interaction occurred between the CV dye and both selected micro and nanoclay surfaces. The maximum adsorption capacities of NCQ1 and NCQ3 adsorbents were 206.73 and 203.66 mg/g, respectively, at 25 °C. The thermodynamic factors revealed that the CV dye adsorption of both micro and nanoclays was spontaneous and showed an exothermic process. Therefore, the examined natural micro and nanoclays adsorbents are promising effective adsorbents for the elimination of CV dye from an aqueous environment.
Multi-Band Analogue Electromagnetically Induced Transparency in DoubleTuned Metamaterials
Authors: Huang Wei , He Ningye , Ning Renxia , Chen Zhenhai
Published: October 2021

A multi-band analogue electromagnetically induced transparency (A-EIT) metamaterial is proposed. The structure is composed of liquid crystal (LC) layer and a graphene strips layer on both sides of silicon dioxide. The transmission spectrum and electric field distribution of only one graphene strip and two graphene strips have been studied. As a bright mode, the graphene strip is coupled with adjacent graphene strip to realize the A-EIT effect. When multiple graphene strips are coupled with each other, the multi-band A-EIT is obtained due to the electric dipole resonances of the four strips. The results show that the multiband A-EIT effect can be tuned by voltage on LC and graphene layer, respectively. Moreover, changing the incident angle of the electromagnetic wave has had little influence on the transmission window in the low frequency band, it is meaning that the A-EIT effect with insensitive to the incident angle can be obtained. Each transmission window has a high maximum transmittance and figure of merit (FOM). The multi-band A-EIT effect can widen the application on sensor and optical storage devices.
Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
Authors: Popova Victoriya , Poletaeva Yuliya , Pyshnaya Inna , Pyshnyi Dmitrii , Dmitrienko Elena
Published: October 2021

Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO3 (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: DOXorubicin (DOX). We also showed a prolonged pH-dependent release of DOX from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO3-and-DOX–based composite (CaNP7-DOX) in in vitro models.
Subjective Health, Physical Activity, Body Image and School Wellbeing among Adolescents in South of Sweden
Authors: Sollerhed Ann-Christin , Lilja Emma , Heldt Holmgren Emily , Garmy Pernilla
Published: October 2021

This study aimed to investigate subjective health and its associations with perceived body image (body appearance and body functioning), physical activity, perceived wellbeing in school, perceived family financial situation, and body mass index among 13- to 15-year-old boys and girls. The study was a cross-sectional study performed in four municipalities in Southern Sweden. Data were obtained from questionnaires completed by adolescents (median age 14; range: 13–15) in Sweden (n = 1518, 51% girls), with a participation rate of 73%. Body weight and body height were measured by school nurses and body mass index was calculated. Logistic regression analyses were carried out with subjective health as the dependent variable. Independent variables included in the model were perceived wellbeing in school, perceived family financial situation, perceived body image, physical activity, body mass index, sex, and residency. Variables significantly associated with good subjective health were good wellbeing in school, a perceived good family financial situation, perceived positive body appearance, perceived positive body functioning, being a boy, and high physical activity. Residency and body mass index were not associated with subjective health. Good subjective health is associated with good wellbeing in school, good family financial situation, positive body image, and high physical activity levels. The results highlight the importance of good school climates, the promotion of positive body image, and increased physical activity for adolescents.
Friends or Foes? Cytotoxicity, HPTLC and NMR Analyses of Some Important Naturally Occurring Hydroxyanthraquinones
Authors: Al Kazman Bassam S. M. , Prieto Jose M.
Published: October 2021

Hydroxyanthraquinones from plants have been used as both medicinal active ingredients and adulterants in slimming food supplements. Although sensible doses of certain natural hydroxyanthraquinones for laxative effects are generally safe in the short term, chronic intake has been related to tumorigenic, carcinogenic, and genotoxic effects. However, an increasing number of researchers are reporting the antiproliferative properties of the same ingredients in cancer cells, pointing towards a potential nutraceutical value for cancer prevention. Previous studies have evaluated anthraquinones’ anti-proliferative activity against various tumour cell lines and bioavailability in Caco-2 cells. However, there are scarce data about both their cytotoxicity in the later cell line and long-term stability. Therefore, this study will check the purity of several ‘aged’ samples using mutually complementary analytical techniques such as HPTLC and NMR assays as well as evaluate the anti-proliferative activity of the purest of these samples using the Caco-2 cell line. The chromatographic and spectroscopic analyses confirmed the long-term stability of those compounds, and their cytotoxic activity resulted in chrysazin (15 µg/mL) > catenarin (27.29 µg/mL) > rhein (49.55 µg/mL) > helminthosporin (52.91 µg/mL) > aloe-emodin (55.34 µg/mL). Our succinct review of the cytotoxicity of these compounds afforded two results: that this is the first clear report for catenarin being active in colon cancer cells and that this class of compounds needs to be better studied to clearly evaluate their benefit/risk profile in regard to both new chemo preventative nutraceuticals and anticancer therapies.
In-Depth Longitudinal Comparison of Clinical Specimens to Detect SARS-CoV-2
Authors: Defêche Justine , Azarzar Samira , Mesdagh Alyssia , Dellot Patricia , Tytgat Amandine , Bureau Fabrice , Gillet Laurent , Belhadj Yasmine , Bontems Sebastien , Hayette Marie-Pierre , Schils Raphaël , Rahmouni Souad , Ernst Marie , Moutschen Michel , Darcis Gilles
Published: October 2021

The testing and isolation of patients with coronavirus disease 2019 (COVID-19) are indispensable tools to control the ongoing COVID-19 pandemic. PCR tests are considered the “gold standard” of COVID-19 testing and mostly involve testing nasopharyngeal swab specimens. Our study aimed to compare the sensitivity of tests for various sample specimens. Seventy-five participants with confirmed COVID-19 were included in the study. Nasopharyngeal swabs, oropharyngeal swabs, Oracol-collected saliva, throat washes and rectal specimens were collected along with pooled swabs. Participants were asked to complete a questionnaire to correlate specific clinical symptoms and the symptom duration with the sensitivity of detecting COVID-19 in various sample specimens. Sampling was repeated after 7 to 10 days (T2), then after 14 to 20 days (T3) to perform a longitudinal analysis of sample specimen sensitivity. At the first time point, the highest percentages of SARS-CoV-2-positive samples were observed for nasopharyngeal samples (84.3%), while 74%, 68.2%, 58.8% and 3.5% of throat washing, Oracol-collected saliva, oropharyngeal and rectal samples tested positive, respectively. The sensitivity of all sampling methods except throat wash samples decreased rapidly at later time points compared to the first collection. The throat washing method exhibited better performance than the gold standard nasopharyngeal swab at the second and third time points after the first positive test date. Nasopharyngeal swabs were the most sensitive specimens for early detection after symptom onset. Throat washing is a sensitive alternative method. It was found that SARS-CoV-2 persists longer in the throat and saliva than in the nasopharynx.
Gender and Pharmacists’ Career Satisfaction in the United States
Authors: Carvajal Manuel J. , Popovici Ioana , Hardigan Patrick C.
Published: October 2021

Job satisfaction reflects pharmacists’ evaluation of their current work experiences, while career satisfaction is an evaluation of how satisfied pharmacists are with their profession across various jobs. The objectives of this article were to measure career satisfaction and specific facets of current-job satisfaction of U.S. pharmacists, compare satisfaction across genders, and examine the determinants of career satisfaction. This study was based on self-reported survey data collected from a random sample of licensed pharmacists practicing throughout the United States. The sample consisted of 422 men and 315 women. Within each gender, pharmacists’ career satisfaction was modeled using ordinary least squares as a function of three sets of variables: personal characteristics, earnings and workweek, and other job-related variables. Female pharmacists exhibited higher levels of contentment with their careers than their male counterparts. Their career-satisfaction levels were not affected by age, marital status, annual earnings, or average workweek, covariates that systematically influenced male pharmacists’ career satisfaction. Job satisfaction substantially affected pharmacists’ long-term career satisfaction. Male and female pharmacists responded differently to stimuli, so a uniform set of work-related incentives may not be effective for both genders. Initiatives perceived by male practitioners as increasing satisfaction may be adversely perceived by female practitioners, and vice-versa.
Dialog between Kingdoms: Enemies, Allies and Peptide Phytohormones
Authors: Dodueva Irina , Lebedeva Maria , Lutova Lyudmila
Published: October 2021

Various plant hormones can integrate developmental and environmental responses, acting in a complex network, which allows plants to adjust their developmental processes to changing environments. In particular, plant peptide hormones regulate various aspects of plant growth and development as well as the response to environmental stress and the interaction of plants with their pathogens and symbionts. Various plant-interacting organisms, e.g., bacterial and fungal pathogens, plant-parasitic nematodes, as well as symbiotic and plant-beneficial bacteria and fungi, are able to manipulate phytohormonal level and/or signaling in the host plant in order to overcome plant immunity and to create the habitat and food source inside the plant body. The most striking example of such phytohormonal mimicry is the ability of certain plant pathogens and symbionts to produce peptide phytohormones of different classes. To date, in the genomes of plant-interacting bacteria, fungi, and nematodes, the genes encoding effectors which mimic seven classes of peptide phytohormones have been found. For some of these effectors, the interaction with plant receptors for peptide hormones and the effect on plant development and defense have been demonstrated. In this review, we focus on the currently described classes of peptide phytohormones found among the representatives of other kingdoms, as well as mechanisms of their action and possible evolutional origin.
A Personal History in Parasitic Weeds and Their Control
Authors: Parker Chris
Published: October 2021

This invited paper summarises a career in which I became increasingly involved in research and related activities on Striga and other parasitic weeds. It also presents a personal view of the present status of parasitic weed problems and their control.
Diversity and Genetic Structure of Dioon holmgrenii (Cycadales: Zamiaceae) in the Mexican Pacific Coast Biogeographic Province: Implications for Conservation
Authors: Velasco-García Mario Valerio , Ramírez-Herrera Carlos , López-Upton Javier , Valdez-Hernández Juan Ignacio , López-Sánchez Higinio , López-Mata Lauro
Published: October 2021

Dioon holmgrenii De Luca, Sabato et Vázq.Torres is an endangered species; it is endemic and its distribution is restricted to the biogeographic province of the Mexican Pacific Coast. The aim of this work was to determine the diversity and genetic structure of nine populations. The genetic diversity parameters and Wright’s F statistics were determined with six microsatellite loci. The genetic structure was determined by using the Structure software and by a discriminant analysis. The genetic diversity of the populations was high. The proportion of polymorphic loci was 0.89, the observed heterogeneity was higher (Ho = 0.62 to 0.98) than expected (He = 0.48 to 0.78), and the fixation index was negative (IF = −0.091 to −0.601). Heterozygous deficiency (FIT = 0.071) was found at the species level and heterozygotes excess (FIS = −0.287) at the population level. The genetic differentiation between populations was high (FST = 0.287), with the number of migrants less than one. Three groups of populations were differentiated, and the variation within populations, between populations, and between groups was: 65.5, 26.3, and 8.2%, respectively. Multiple factors explain the high genetic diversity, while the genetic structure is due to geographic barriers. Community reserves are urgent in at least one most diverse population of each group.
Electrostatic Solitary Structures in Space Plasmas: Soliton Perspective
Authors: Lakhina Gurbax Singh , Singh Satyavir , Rubia Rajith , Devanandhan Selvaraj
Published: October 2021

Occurrence of electrostatic solitary waves (ESWs) is ubiquitous in space plasmas, e.g., solar wind, Lunar wake and the planetary magnetospheres. Several theoretical models have been proposed to interpret the observed characteristics of the ESWs. These models can broadly be put into two main categories, namely, Bernstein–Green–Kruskal (BGK) modes/phase space holes models, and ion- and electron- acoustic solitons models. There has been a tendency in the space community to favor the models based on BGK modes/phase space holes. Only recently, the potential of soliton models to explain the characteristics of ESWs is being realized. The idea of this review is to present current understanding of the ion- and electron-acoustic solitons and double layers models in multi-component space plasmas. In these models, all the plasma species are considered fluids except the energetic electron component, which is governed by either a kappa distribution or a Maxwellian distribution. Further, these models consider the nonlinear electrostatic waves propagating parallel to the ambient magnetic field. The relationship between the space observations of ESWs and theoretical models is highlighted. Some specific applications of ion- and electron-acoustic solitons/double layers will be discussed by comparing the theoretical predictions with the observations of ESWs in space plasmas. It is shown that the ion- and electron-acoustic solitons/double layers models provide a plausible interpretation for the ESWs observed in space plasmas.
Fast and Flexible mRNA Vaccine Manufacturing as a Solution to Pandemic Situations by Adopting Chemical Engineering Good Practice—Continuous Autonomous Operation in Stainless Steel Equipment Concepts
Authors: Schmidt Axel , Helgers Heribert , Vetter Florian Lukas , Juckers Alex , Strube Jochen
Published: October 2021

SARS-COVID-19 vaccine supply for the total worldwide population has a bottleneck in manufacturing capacity. Assessment of existing messenger ribonucleic acid (mRNA) vaccine processing shows a need for digital twins enabled by process analytical technology approaches in order to improve process transfer for manufacturing capacity multiplication, a reduction in out-of-specification batch failures, qualified personal training for faster validation and efficient operation, optimal utilization of scarce buffers and chemicals and speed-up of product release by continuous manufacturing. In this work, three manufacturing concepts for mRNA-based vaccines are evaluated: Batch, full-continuous and semi-continuous. Technical transfer from batch single-use to semi-continuous stainless-steel, i.e., plasmid deoxyribonucleic acid (pDNA) in batch and mRNA in continuous operation mode, is recommended, in order to gain: faster plant commissioning and start-up times of about 8–12 months and a rise in dose number by a factor of about 30 per year, with almost identical efforts in capital expenditures (CAPEX) and personnel resources, which are the dominant bottlenecks at the moment, at about 25% lower operating expenses (OPEX). Consumables are also reduceable by a factor of 6 as outcome of this study. Further optimization potential is seen at consequent digital twin and PAT (Process Analytical Technology) concept integration as key-enabling technologies towards autonomous operation including real-time release-testing.
The Search for the Elixir of Life: On the Therapeutic Potential of Alkaline Reduced Water in Metabolic Syndromes
Authors: Delos Reyes Felippe Steven Louis G. , Mamaril Adrian Carlo C. , Matias Trisha Joy P. , Tronco Mary Kathleen V. , Samson Gabriel R. , Javier Nyczl D. , Fadriquela Ailyn , Antonio Jayson M. , Sajo Ma Easter Joy V.
Published: October 2021

Our body composition is enormously influenced by our lifestyle choices, which affect our health and longevity. Nutrition and physical activities both impact overall metabolic condition, thus, a positive energy balance causes oxidative stress and inflammation, hastening the development of metabolic syndrome. With this knowledge, boosting endogenous and exogenous antioxidants has emerged as a therapeutic strategy for combating metabolic disorders. One of the promising therapeutic inventions is the use of alkaline reduced water (ARW). Aside from its hydrating and non-caloric properties, ARW has demonstrated strong antioxidant and anti-inflammatory properties that can help stabilize physiologic turmoil caused by oxidative stress and inflammation. This review article is a synthesis of studies where we elaborate on the intra- and extracellular effects of drinking ARW, and relate these to the pathophysiology of common metabolic disorders, such as obesity, diabetes mellitus, non-alcoholic fatty liver disease, and some cancers. Highlighting the health-promoting benefits of ARW, we also emphasize the importance of maintaining a healthy lifestyle by incorporating exercise and practicing a balanced diet as forms of habit.
Estimating Relaxation Time and Fractionality Order Parameters in Fractional Non-Fourier Heat Conduction Using Conjugate Gradient Inverse Approach in Single and Three-Layer Skin Tissues
Authors: Goudarzi Piran , Abidi Awatef , Mehryan Seyed Abdollah Mansouri , Ghalambaz Mohammad , Sheremet Mikhail A.
Published: October 2021

In this work, the relaxation parameter (τ) and fractionality order (α) in the fractional single phase lag (FSPL) non-Fourier heat conduction model are estimated by employing the conjugate gradient inverse method (CGIM). Two different physics of skin tissue are chosen as the studied cases; single and three-layer skin tissues. Single-layer skin is exposed to laser radiation having the constant heat flux of Qin. However, a heat pulse with constant temperature is imposed on the three-layer skin. The required inputs for the inverse problem in the fractional diffusion equation are chosen from the outcomes of the dual phase lag (DPL) theory. The governing equations are solved numerically by utilizing implicit approaches. The results of this study showed the efficiency of the CGIM to estimate the unknown parameters in the FSPL model. In fact, obtained numerical results of the CGIM are in excellent compatibility with the FSPL model.
Best Conditions for the Production of Natural Isopentyl Acetate (Banana Aroma) from Cheese Industry Waste: An Experimental Precursor Approach
Authors: Gómez-Aldapa Carlos Alberto , Castro-Rosas Javier , López-Molina Antioco , Conde-Mejía Carolina , Pineda-Muñoz Cuauhtémoc Francisco , Jiménez-González Angélica , Medina-Moreno Sergio Alejandro , Falcón-León Martha Patricia , Conde-Báez Laura
Published: October 2021

In some fermentation systems, whey components (lactose, proteins and minerals) can produce isopentyl acetate (IA). An analysis of the best conditions for IA production with Kluyveromyces marxianus was developed in this work. The experiment design was two-factor and three-level design based on a response surface methodology (RSM) using Design-Expert® software. The analysis of anomeric protons by nuclear magnetic resonance (1H-NMR) showed 81.25% of β lactose content. This characteristic favored the production of IA. The maximum output (Mp) of IA, determined by gas chromatography, was 9.52 g/L (p < 0.05). The central composite design (CCD) was used to perform the factor analysis. Results showed that concentrations of 0.03 (g/L) ammonium sulphate and 0.3 (v/v) of isoamyl alcohol are the best conditions for a maximum rate of IA production. The production of IA can reduce the discharge of whey, allowing its reuse and revaluation.
Reducing the Internal Stress of Fe-Ni Magnetic Film Using the Electrochemical Method
Authors: Wu Yan , Ji Bin , Wang Wei
Published: October 2021

Soft magnetic materials are important functional materials in the electrical engineering, radio, and high-tech fields, but thin and brittle flakes present challenges to the manufacturing industry. In this study, the effect and mechanism of saccharin sodium in reducing the internal stress of Fe-Ni magnetic films were analyzed. The effects of the pH value, temperature, and the concentration of saccharin sodium on the deposition process of Fe-Ni alloys were investigated. The polarization curve of the Fe-Ni alloy deposition process was measured by using a multifunctional electrochemical workstation, and the morphology and crystal structure were measured by a scanning electron microscope (SEM) and X-ray diffraction (XRD). The results show that saccharin sodium significantly reduced the stress of the iron-nickel magnetic film; the mechanism through which the internal stress was reduced is analyzed in this paper. Briefly, the Fe2+ and the amino group of saccharin sodium synthesized a metal complex with positive charge on the surface of the electrode, which prevented the hydrogen ions from approaching the cathode and increased the discharge activation energy of the hydrogen ion, which reduced the hydrogen evolution and improved the internal stress of the coating. This research will help to solve the challenges of producing magnetic film, and promotes the application of new stress-reducing agents.
Devotional Foundations of Earthly Sovereignty: Conceptualizing Sovereignty and the Role of Devotion in Narrative Political Theology in Premodern India
Authors: Simmons Caleb
Published: October 2021

The central premise of this article is that narrative literature from premodern India can give us insights into the ways that sovereignty was conceptualized within broader cosmological structures, creating what has been called “political theology” in other contexts. Looking to narratives for theology can give us particular insights into a tradition’s self-description. It is through narratives that Indian kings and their courts were able to describe the intentional-agential worlds of political hierarchies on a cosmic scale and situate themselves within this broader structure. This article, therefore, examines narratives from Purāṇas, particularly the Viṣṇu Purāṇa and the Dēvī Māhātmya, and dynastic foundational stories and genealogies from Karnataka found in vaṃśāvaḷis and epigraphic praśastis, using a twelfth-century Western Gaṅga inscription as an example, to see the political theologies from the premodern courts of India as they are articulated and performed in and between the realms of the divine and on Earth. After an examination of these materials, this article offers a new model to explain how premodern courts viewed their sovereignty vis-à-vis other divine and earthly sovereigns and how they understood the constitution, transfer, and diffusion of sovereignty throughout this cosmic spectrum of divine and earthly royalty through devotion and giving.
Pathological Changes of the Rumen in Small Ruminants Associated with Indigestible Foreign Objects
Authors: Martín Martel Sergio , Morales Manuel , Morales Inmaculada , Jaber José Raduan , Rodríguez-Guisado Francisco , Tejedor-Junco María Teresa , Corbera Juan Alberto
Published: October 2021

The use of agriculture by-products is highly demanded for livestock nutrition. However, the employment of certain non-degradable materials could potentially induce concretions and lesions in ruminants’ forestomach. Thus, the aim of this study was to determine the morphological lesions showed in rumen containing indigestible foreign objects, named foreign bodies, in small ruminants. Twenty-two animals (12 goats and 10 ewes) presenting foreign bodies (2.750 ± 1.577 kg) were included in this study. Rumenotomies were performed to remove the foreign bodies, and rumen samples were taken for further morphological evaluations. Rumen samples from healthy small ruminants (n = 24) were also taken at slaughterhouses as controls. Morphologically, the rumen from affected animals showed a significant reduction of the ruminal papillae length (1.243 vs. 3.097), hyperplasia of the squamous epithelium, mononuclear infiltration in the subepithelial spaces and, less consistently, vacuolization of keratinocytes, presence of intraepithelial leukocytes and vascular changes of the lamina propria. It can be concluded that indigestible foreign bodies would cause ruminal lesions that would be able to trigger inflammatory and/or degenerative lesions. Our study demonstrates morphological lesions because of the presence of intraruminal foreign bodies, but further studies on the functional activity of the rumen in these cases are required. The avoidance of the presence of indigestible materials in agriculture exploitations is highly recommended in order to prevent the accumulation of indigestible foreign objects in small ruminants.
The Employment Ecosystem of Bizkaia as an Emerging Common in the Face of the Impact of COVID-19
Authors: Atutxa Ekhi , Calvo-Sotomayor Iñigo , Laespada Teresa
Published: October 2021

In the context of the impact of COVID-19 pandemic in Bizkaia (Basque Country, Spain), and from the renewed Commons paradigm, this research analyzes the initial response given by the region’s employment ecosystem. Based on extensive quantitative and qualitative methods, it empirically explores the catalytic role that local public and social entities could play in coordinating an organized and systemic response of the employment-related stakeholders to an external impact, such as the current pandemic. The study of databases specifically provided by the Public Administrations for this research, in combination with two survey processes conducted to the main agents of the ecosystem, led to a greater understanding of the benefits of an organized and systemic reaction. From the community identification of a priori unrecognized impacts by individual actors to the proposal of actions closely connected to their short and long-term needs, the article finally presents recommendations aimed at strengthening the resilience and collaboration of the collective action.
A Hybrid Neural Network–Particle Swarm Optimization Informed Spatial Interpolation Technique for Groundwater Quality Mapping in a Small Island Province of the Philippines
Authors: De Jesus Kevin Lawrence M. , Senoro Delia B. , Dela Cruz Jennifer C. , Chan Eduardo B.
Published: October 2021

Water quality monitoring demands the use of spatial interpolation techniques due to on-ground challenges. The implementation of various spatial interpolation methods results in significant variations from the true spatial distribution of water quality in a specific location. The aim of this research is to improve mapping prediction capabilities of spatial interpolation algorithms by using a neural network with the particle swarm optimization (NN-PSO) technique. Hybrid interpolation approaches were evaluated and compared by cross-validation using mean absolute error (MAE) and Pearson’s correlation coefficient (R). The governing interpolation techniques for the physicochemical parameters of groundwater (GW) and heavy metal concentrations were the geostatistical approaches combined with NN-PSO. The best methods for physicochemical characteristics and heavy metal concentrations were observed to have the least MAE and R values, ranging from 1.7 to 4.3 times and 1.2 to 5.6 times higher than the interpolation technique without the NN-PSO for the dry and wet season, respectively. The hybrid interpolation methods exhibit an improved performance as compared to the non-hybrid methods. The application of NN-PSO technique to spatial interpolation methods was found to be a promising approach for improving the accuracy of spatial maps for GW quality.
Multimodal Analysis of Gravitational Wave Signals and Gamma-Ray Bursts from Binary Neutron Star Mergers
Authors: Cuoco Elena , Patricelli Barbara , Iess Alberto , Morawski Filip
Published: October 2021

A major boost in the understanding of the universe was given by the revelation of the first coalescence event of two neutron stars (GW170817) and the observation of the same event across the entire electromagnetic spectrum. With third-generation gravitational wave detectors and the new astronomical facilities, we expect many multi-messenger events of the same type. We anticipate the need to analyse the data provided to us by such events not only to fulfil the requirements of real-time analysis, but also in order to decipher the event in its entirety through the information emitted in the different messengers using machine learning. We propose a change in the paradigm in the way we do multi-messenger astronomy, simultaneously using the complete information generated by violent phenomena in the Universe. What we propose is the application of a multimodal machine learning approach to characterize these events.
A Simple Model of Radiation from a Magnetized Neutron Star: Accreted Matter and Polar Hotspots
Authors: Yakovlev Dmitry
Published: October 2021

A simple and well known model for thermal radiation spectra from a magnetized neutron star is further studied. The model assumes that the star is internally isothermal and possesses a dipole magnetic field (B≲1014 G) in the outer heat-insulating layer. The heat transport through this layer makes the surface temperature distribution anisotropic; any local surface element is assumed to emit a blackbody (BB) radiation with a local effective temperature. It is shown that this thermal emission is nearly independent of the chemical composition of insulating envelope (at the same taken averaged effective surface temperature). Adding a slight extra heating of magnetic poles allows one to be qualitatively consistent with observations of some isolated neutron stars.
Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
Authors: Chan Joel Ern Zher , Irimpen Anand
Published: October 2021

A 79-year-old female patient with no pre-existing rheumatological conditions presented with severe functional impairment secondary to polyarthralgia, most likely an adverse reaction following her first dose of Oxford/AstraZeneca ChAdOx1 nCov-19 vaccination against SARS-CoV-2, the causative agent of Coronavirus Disease 2019 (COVID-19). The presentation mimicked clinical features of polymyalgia rheumatica and was distinctive in its pattern and delayed onset. Its severity in an elderly patient was significant against trial findings of decreasing reactogenicity of ChAdOx1 nCov-19 vaccine with increasing age, and traumatic to the patient. Acute phase reactants were elevated, consistent with recent similar reports among mostly elderly, female patients. New onset rheumatological conditions and flares of pre-existing, well-controlled conditions had been well established in COVID-19 and, to a lesser extent, post-vaccination. Viral arthralgias as a distinct clinical entity in COVID-19 is only beginning to be recognized. It could be that this case report represents a similar entity which occurs following vaccination against SARS-CoV-2. Despite this, the benefits of vaccination continue to outweigh such risks, although this case report is important for providing understanding of clinical progression when such reactions occur, aiding in patient discussions and clinical decisions to weigh up further investigations or empirical treatment against reassurance and close monitoring.
EV Adoption Influence on Air Quality and Associated Infrastructure Costs
Authors: Christensen Carsten , Salmon John
Published: October 2021

Exploring the system-level interactions within the modern urban transportation system, factors such as human health, vehicle exhaust pollution, air quality, emerging personal transportation technologies, and local weather events, are increasingly expedient considering the growth of human population centers projected in the 21st century. Pollutants often accumulate to unhealthy concentrations during winter inversion events such as those that commonly occur in Utah’s Salt Lake valley and other mountainous regions. This work examines the degree to which replacing conventionally powered vehicles with electric vehicles (EV) could reduce the near-road accumulation of criteria pollutants under various degrees of inversion depth and wind speed. Vehicle emissions data are combined with inversion and wind factors to determine changes in the Air Quality Index, and a first-order estimate of the cost required to build an EV charging infrastructure to support a given EV adoption scenario is also derived. Results are presented in the form of multiple Pareto frontiers and a simplified cost–benefit formula that inform potential public and private EV charging infrastructure investments to drive the EV adoption that would result in optimal air quality improvements during average weather and winter inversion events.
Transanal rectopexy for external rectal prolapse
Authors: Chivate Shantikumar Dhondiram , Chougule Meghana Vinay , Chivate Rahul Shantikumar , Thakrar Palak Harshuk
Published: October 2021

Purpose: The surgical management of patients with full-thickness rectal prolapse (FTRP) continues to remain a challenge in the laparoscopic era. This study retrospectively assesses a cohort of patients undergoing a transanal suture sacro rectopexy supported by sclerosant injection into the presacral space under ultrasound guidance.Methods: Patients with FTRP underwent a sutured transrectal presacral fixation of 2/3 of the circumference of the rectum from the third sacral vertebra to the sacrococcygeal junction through a side-viewing operating proctoscope. The procedure was supplemented by ultrasound-guided injection into the retrorectal space of a 2 mL solution of sodium tetradecyl sulfate/polidocanol mixed with air. Patients were functionally assessed before and 6 months after surgery with the Agachan constipation score and the Pescatori incontinence score.Results: There were 36 adult patients (26 males; the range of age, 23–92 years). The mean operative time was 27 minutes (range, 23–50 minutes) with no recorded perioperative morbidity. The median follow-up was 66 months (range, 48–84 months) with 1 (2.8%) recurrence presenting 18 months after surgery. There were 19 patients (52.8%) who presented with incontinence before surgery with 17 out of 19 (89.5%) reporting improvement in their Pescatori score (P<0.001). No patient had worsening incontinence and there were no de novo incontinence cases. Constipation scores improved in 23 out of 36 patients (63.9%) with a mean score reduction difference of 7.91 (P=0.001).Conclusion: Transanal sutured sacral rectopexy with supplemental presacral sclerosant injection is safe and effective in the management of FTRP with sustained improvement in bowel function.
INTEGRATED TRANSPORT PLANNING IN THE CONTEXT OF A PROMISING TERRITORIAL CITY DEVELOPMENT
Authors:   Krasnoyarsk Administration, EREMIN S.V.
Published: October 2021

The paper considers the issues of planning the development of transport infrastructure in the context of the prospective territorial development of the city. Integrated transport planning in-volves taking into account many aspects in the process of developing transport system development plans. The aim of the work is to develop a scientific approach to integrated transport planning in the conditions of prospective territorial development of the city. Therefore, the article presents a multi-criteria optimization method based on the method of successive concessions, which allows us to find the most rational solution to the scheme of implementation of transport construction. The results of the study are presented on the example of the transport network of the city of Krasno-yarsk.
ANALYSIS OF METHODS FOR DETERMINING THE PERFORMANCE OF VEHICLES
Authors:   St. Petersburg State University of Architecture, TERENTYEV A.V. , KARELINA M.YU. ,   Moscow automobile and road construction, KLIMENKO V.A. ,   National Research Tomsk State University
Published: October 2021

The purpose of the study presented in this article is to adapt the technical operation system of the car to modern conditions. At the same time, the purpose of the technical operation system of the car should be determined not in the direction of ensuring the maximum long life of the car, but in the direction of achieving the level of reliability and efficiency and quality of cars for a limited mileage specified by the regulatory and technical documentation. Upon reaching this level, the car must be decommissioned, even if it has not developed its resource.