bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial
Authors: Furuta Shunsuke , Sugiyama Takao , Umibe Takeshi , Kaneko Yuko , Amano Koichi , Kurasawa Kazuhiro , Nakaomi Daiki , Hiraguri Masaki , Hanaoka Hideki , Sato Yasunori , Ikeda Kei , Nakajima Hiroshi
Published: December 2017

Introduction

Antineutrophil cytoplasm antibody-associated vasculitis (AAV) is a form of systemic vasculitis. The current standard induction therapy with the combination of high-dose glucocorticoids and cyclophosphamide or rituximab has high remission rates of 80%–90%. However, it is also associated with various side effects, including death due to infection or cardiovascular disease. There is an unmet medical need of a new therapy to reduce side effects.

Methods and analysis

This is a phase IV multicentre, open-label, randomised controlled trial that aims to evaluate the efficacy and safety of a new remission induction regimen with the combination of low-dose glucocorticoids and rituximab. Newly diagnosed patients with AAV will be assessed for eligibility at 34 tertiary rheumatology/nephrology centres in Japan. One hundred and forty patients will be randomised (1:1) to receive low-dose prednisolone (0.5 mg/kg daily) plus rituximab (375 mg/m2weekly) or high-dose prednisolone (1 mg/kg daily) plus rituximab. The trial consists of remission induction and maintenance phases. The primary endpoint of the study is the remission rate at 6 months (induction phase). Relapse and long-term safety profile will also be assessed until 24 months (maintenance phase).

Ethics and dissemination

The protocol was first approved by the Institutional Review Board of Chiba University Hospital (reference number: G25051), and then approved by each participating site. The trial was registered at the University hospital Medical Information Network (UMIN) clinical registry (UMIN000014222) and ClinicalTrials.gov registry (NCT02198248). The Low-dose Glucocorticoid Vasculitis Induction Study (LoVAS) trial is currently ongoing and is due to finish in September 2019. The findings of this trial will be disseminated to participants through peer-reviewed publications and presented at national and international conferences in accordance with the Consolidated Standards of Reporting Trials (CONSORT) Statement.

Trial registration number

UMIN000014222;NCT02198248.
Evaluation of anticoagulation status for atrial fibrillation on early ischaemic stroke outcomes: a registry-based, prospective cohort study of acute stroke care in Surrey, UK
Authors: Han Thang S , Fry Christopher H , Fluck David , Affley Brendan , Gulli Giosue , Barrett Christopher , Kakar Puneet , Patel Tasmin , Sharma Sapna , Sharma Pankaj
Published: December 2017

Objective

The relationship of anticoagulation therapies with stroke severity and outcomes have been well documented in the literature. However, none of the previous research has reported the relationship of atrial fibrillation (AF)/anticoagulation therapies with urinary tract infection (UTI), pneumonia and length of stay in hyperacute stroke units (HASUs). The present study aimed to evaluate AF and anticoagulation status in relation to early outcomes in 1387 men (median age=75 years, IQR=65–83) and 1371 women (median age=83 years, IQR=74–89) admitted with acute ischaemic stroke to HASUs in Surrey between 2014 and 2016.

Methods

We conducted this registry-based, prospective cohort study using data from the Sentinel Stroke National Audit Programme. Association between AF anticoagulation status with severe stroke on arrival (National Institutes of Health Stroke Scale score ≥16), prolonged HASU stay (>3 weeks), UTI and pneumonia within 7 days of admission, severe disability on discharge (modified Rankin Scale score=4 and 5) and inpatient mortality was assessed by logistic regression, adjusted for age, sex, hypertension, congestive heart failure, diabetes and previous stroke.

Results

Compared with patients with stroke who are free from AF, those with AF without anticoagulation had an increased adjusted risk of having more severe stroke: 5.8% versus 14.0%, OR=2.4 (95% CI 1.6 to 3.6, P<0.001), prolonged HASU stay: 21.5% versus 32.0%, OR=1.4 (1.0–2.0, P=0.027), pneumonia: 8.2% versus 19.1%, OR=2.1 (1.4–2.9, P<0.001), more severe disability: 24.2% versus 40.4%, OR=1.6 (1.2–2.1, P=0.004) and mortality: 9.3% versus 21.7%, OR=1.9 (1.4–2.8, P<0.001), and AF patients with anticoagulation also had greater risk for having UTI: 8.6% versus 12.3%, OR=1.9 (1.2–3.0, P=0.004), pneumonia: 8.2% versus 11.5%, OR=1.6 (1.1–2.4, P=0.025) and mortality: 9.7% versus 21.7%, OR=1.9 (1.4–2.8, P<0.001). The median HASU stay for stroke patients with AF without anticoagulation was 10.6 days (IQR=2.8–26.4) compared with 5.8 days (IQR=2.3–17.5) for those free from AF (P<0.001).

Conclusions

Patients with AF, particularly those without anticoagulation, are at increased risk of severe stroke, associated with prolonged HASU stay and increased risk of early infection, disability and mortality.
Deterministic Stack Transducers
Authors: Bensch Suna , Björklund Johanna , Kutrib Martin
Published: December 2017

We introduce and investigate stack transducers, which are one-way stack automata with an output tape. A one-way stack automaton is a classical pushdown automaton with the additional ability to move the stack head inside the stack without altering the contents. For stack transducers, we distinguish between a digging and a non-digging mode. In digging mode, the stack transducer can write on the output tape when its stack head is inside the stack, whereas in non-digging mode, the stack transducer is only allowed to emit symbols when its stack head is at the top of the stack. These stack transducers have a motivation from natural-language interface applications, as they capture long-distance dependencies in syntactic, semantic, and discourse structures. We study the computational capacity for deterministic digging and non-digging stack transducers, as well as for their non-erasing and checking versions. We finally show that even for the strongest variant of stack transducers the stack languages are regular.
Elasticity, slowness, thermal conductivity and the anisotropies in the Mn3Cu1−xGexN compounds
Authors: Li Guan-Nan , Chen Zhi-Qian , Lu Yu-Ming , Hu Meng , Jiao Li-Na , Zhao Hao-Ting
Published: December 2017

We perform the first-principles to systematically investigate the elastic properties, minimum thermal conductivity and anisotropy of the negative thermal expansion compounds Mn3Cu[Formula: see text]Ge[Formula: see text]N. The elastic constant, bulk modulus, shear modulus, Young’s modulus and Poisson ratio are calculated for all the compounds. The results of the elastic constant indicate that all the compounds are mechanically stable and the doped Ge can adjust the ductile character of the compounds. According to the values of the percent ratio of the elastic anisotropy A[Formula: see text], A[Formula: see text] and A[Formula: see text], shear anisotropic factors A1, A2 and A3, all the Mn3Cu[Formula: see text]Ge[Formula: see text]N compounds are elastic anisotropy. The three-dimensional diagrams of elastic moduli in space also show that all the compounds are elastic anisotropy. In addition, the acoustic wave speed, slowness, minimum thermal conductivity and Debye temperature are also calculated. When the ratio of content for Cu and Ge arrived to 1:1, the compound has the lowest thermal conductivity and the highest Debye temperature.
A Whole-Range S–N Curve for Fatigue Assessment of Steel Orthotropic Bridge Decks
Authors: Zhou Guang-Dong , Yi Ting-Hua , Zhu Tai-Yong , Zhang Huan
Published: December 2017

The fatigue assessment of orthotropic bridge decks under routine traffic loading is a significant task to ensure the serviceability and safety of steel bridges. The sequential law computes fatigue damages using whole-range [Formula: see text]–[Formula: see text] curves and sequential stress histories and has been proven to provide more realistic results than Miner’s rule under variable amplitude loading. In this paper, a whole-range [Formula: see text]–[Formula: see text] curve covering the very low-cycle region, the low-cycle region, the finite life region, the high-cycle region, and the very high-cycle region is proposed for the sequential law to evaluate the fatigue performance of steel orthotropic bridge decks. The mathematical model of the whole-range [Formula: see text]–[Formula: see text] curve is first deduced based on the partially known [Formula: see text]–[Formula: see text] curve recommended in steel bridge design codes. The properties of the whole-range [Formula: see text]–[Formula: see text] curve are then explained from the geometrical point of view in the double logarithm coordinates system. Finally, rib-to-deck joints in steel orthotropic bridge decks are used as a case study. Fatigue test data are used to validate the proposed model. The whole-range [Formula: see text]–[Formula: see text] curve, with a 97.5% survival limit, is established for fatigue assessment of rib-to-deck joints in real bridges. The results show that the proposed whole-range [Formula: see text]–[Formula: see text] curve allows a good fit of experimental data and excellent agreement with code [Formula: see text]–[Formula: see text] curves in the finite life region and provides an effective extrapolation from the finite life region to the whole range of cycle numbers.
Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3Kδ in Mature B-cell Malignancies
Authors: Cooney Jeffrey D. , Lin An-Ping , Jiang Daifeng , Wang Long , Suhasini Avvaru N. , Myers Jamie , Qiu ZhiJun , Wölfler Albert , Sill Heinz , Aguiar Ricardo C.T.
Published: December 2017

Purpose: Aberrant activation of the B-cell receptor (BCR) is implicated in the pathogenesis of mature B-cell tumors, a concept validated in part by the clinical success of inhibitors of the BCR-related kinases BTK (Bruton's tyrosine kinase) and PI3Kδ. These inhibitors have limitations, including the paucity of complete responses, acquired resistance, and toxicity. Here, we examined the mechanism by which the cyclic-AMP/PDE4 signaling axis suppresses PI3K, toward identifying a novel mechanism-based combinatorial strategy to attack BCR-dependency in mature B-cell malignancies.

Experimental Design: We used in vitro and in vivo diffuse large B-cell lymphoma (DLBCL) cell lines and primary chronic lymphocytic leukemia (CLL) samples to preclinically evaluate the effects of the combination of the FDA-approved phosphodiesterase 4 (PDE4) inhibitor roflumilast and idelalisib on cell survival and tumor growth. Genetic models of gain- and loss-of-function were used to map multiple signaling intermediaries downstream of the BCR.

Results: Roflumilast elevates the intracellular levels of cyclic-AMP and synergizes with idelalisib in suppressing tumor growth and PI3K activity. Mechanistically, we show that roflumilast suppresses PI3K by inhibiting BCR-mediated activation of the P85 regulatory subunit, distinguishing itself from idelalisib, an ATP-competitive inhibitor of the catalytic P110 subunit. Using genetic models, we linked the PDE4-regulated modulation of P85 activation to the oncogenic kinase SYK.

Conclusions: These data demonstrate that roflumilast and idelalisib suppress PI3K by distinct mechanisms, explaining the basis for their synergism, and suggest that the repurposing of PDE4 inhibitors to treat BCR-dependent malignancies is warranted. Clin Cancer Res; 24(5); 1103–13. ©2017 AACR.
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus–Related Hepatocellular Carcinoma
Authors: Li Yuanfeng , Zhai Yun , Song Qingfeng , Zhang Haitao , Cao Pengbo , Ping Jie , Liu Xinyi , Guo Bingqian , Liu Guanjun , Song Jin , Zhang Ying , Yang Aiqing , Yan Hongbo , Yang Liang , Cui Ying , Ma Yilong , Xing Jinliang , Shen Xizhong , Liu Taotao , Zhang Hongxin , An Jiaze , Bei Jin-Xin , Jia Weihua , Kang Longli , Liu Lijun , Yuan Dongya , Hu Zhibin , Shen Hongbing , Lu Lei , Wang Xuan , Li Hua , He Fuchu , Zhang Hongxing , Zhou Gangqiao
Published: December 2017

Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chronic hepatitis B virus (HBV) infection remains the major risk factor for HCC. In this study, we performed a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci contributing to susceptibility to HBV-related HCC.

Experimental Design: GWAS scan is performed in a collection of 205 HBV-related HCC trios (each trio includes an affected proband and his/her both parents), and 355 chronic HBV carriers with HCC (cases) and 360 chronic HBV carriers without HCC (controls), followed by two rounds of replication studies totally consisting of 3,796 cases and 2,544 controls.

Results: We identified a novel association signal within the CDK14 gene at 7q21.13 (index rs10272859, OR = 1.28, P = 9.46 × 10−10). Furthermore, we observed that the at-risk rs10272859[G] allele was significantly associated with higher mRNA expression levels of CDK14 in liver tissues. Chromosome conformation capture assays in liver cells confirmed that a physical interaction exists between the promoter region of CDK14 and the risk-associated SNPs in strong linkage disequilibrium with the index rs10272859 at 7q21.13. This index rs10272859 also showed significant association with the survival of HCC patients.

Conclusions: Our findings highlight a novel locus at 7q21.13 conferring both susceptibility and prognosis to HBV-related HCC, and suggest the CDK14 gene to be the functional target of the 7q21.13 locus. Clin Cancer Res; 24(4); 906–15. ©2017 AACR.
International Survey of Speech-Language Pathologists’ Practices in Working with Children with Autism Spectrum Disorder
Authors: Gillon Gail , Hyter Yvette , Fernandes Fernanda Dreux , Ferman Sara , Hus Yvette , Petinou Kakia , Segal Osnat , Tumanova Tatjana , Vogindroukas Ioannis , Westby Carol , Westerveld Marleen
Published: December 2017

Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental impairment. To better understand the role of speech-language pathologists (SLPs) in different countries in supporting children with ASD, the International Association of Logopedics and Phoniatrics (IALP) Child Language Committee developed a survey for SLPs working with children or adolescents with ASD. Method and Participants: The survey comprised 58 questions about background information of respondents, characteristics of children with ASD, and the role of SLPs in diagnosis, assessment, and intervention practices. The survey was available in English, French, Russian, and Portuguese, and distributed online. Results: This paper provides a descriptive summary of the main findings from the quantitative data from the 1,114 SLPs (representing 35 countries) who were supporting children with ASD. Most of the respondents (91%) were experienced in working with children with ASD, and the majority (75%) worked in schools or early childhood settings. SLPs reported that the children’s typical age at diagnosis of ASD on their caseload was 3–4 years, completed mostly by a professional team. Conclusions: The results support positive global trends for SLPs using effective practices in assessment and intervention for children with ASD. Two areas where SLPs may need further support are involving parents in assessment practices, and supporting literacy development in children with ASD.
Optical Coherence Tomography: Clinicopathologic Correlations - The 2016 Gordon K. Klintworth Lecture
Authors: Eagle Jr. Ralph C.
Published: December 2017

Background/Aims: Spectral domain optical coherence tomography (SD-OCT) has become a mainstay of ophthalmic practice that has revolutionized the assessment and treatment of a variety of ocular disorders. Studies that directly correlate SD-OCT and histopathology are necessary to demonstrate the actual nature of the retinal pathology responsible for the images that resemble histologic sections, but are generated by mathematical algorithms. Methods: Careful correlative light microscopy was performed on a small number of eyes undergoing enucleation for intraocular tumors that had pertinent findings imaged by SD-OCT. Expeditious processing and a fixation technique that prevented retinal detachment minimized tissue distortion and sectioning artifact. Results: The retinal layers disclosed by SD-OCT images do not correspond directly to light microscopy. Photoreceptor ellipsoids can persist in foveal detachments without a distinct ellipsoid band in corresponding SD-OCT images. Lipidized histiocytes can appear as bright hyperreflective spots, and clumps of subretinal macrophages as “shaggy photoreceptors” overlying choroidal tumors. Conclusion: The meaningful interpretation of SD-OCT's striking visual imagery requires a firm foundation in ocular histology and pathology. The accuracy of interpretation can be improved by correlative studies that directly compare OCT and histopathology.
Equipollence, suspension of judgment and tranquillity in pyrrhonian skepticism
Authors: Krempel Raquel Albieri
Published: December 2017

Parece haver na filosofia cética, tal como apresentada por Sexto Empírico, três pressupostos fundamentais: (1) a constatação da equipolência entre argumentos contrários levaria necessariamente à suspensão de juízo; (2) aquele que suspende o juízo alcançaria necessariamente a tranquilidade; (3) a suspensão de juízo seria condição suficiente para a obtenção do estado de tranquilidade. Procuraremos problematizar neste artigo esses aspectos centrais do ceticismo pirrônico, tentando mostrar que eles não excluem definitivamente a possibilidade de uma filosofia dogmática. Caberá, também, questionar se esses pressupostos não conferem ao ceticismo um teor dogmático, na medida em que pretende se autoconferir a característica de melhor filosofia a ser seguida
Interaction processes between Lago Grande and Oswaldo archaeological sites (AM) based on ceramic material
Authors: Mongeló Guilherme Zdonek
Published: December 2017

Propõe-se, neste artigo, uma análise dos processos de interação entre os sítios arqueológicos Lago Grande e Oswaldo, localizados no município de Iranduba, estado do Amazonas. A problemática apresentada é o fato de que foi encontrado, em pequena porcentagem, material cerâmico de fase distinta às preponderantes em ambos os sítios. A hipótese que se procurou testar é se as esferas de interação, comuns no contexto amazônico, podem explicar a presença de outra fase cerâmica em um sítio que é, aparentem ente, unicomponencial
Goldziher, Húngaro das Arábias
Authors: Jovanovic Aleksandar
Published: December 2017

O presente texto objetiva apresentar, em linhas gerais, a figura do orientalista húngaro Ignác Goldziher (1850-1921), que conseguiu tornar-se figura respeitada e reconhecida no mundo científico graças ao profundo conhecimento e respeito das culturas do Oriente Médio e, em particular, do mundo árabe. Deixou extensa bibliografia em alemão e húngaro, mas não teve todos os trabalhos traduzidos para as chamadas línguas dominantes. Predecessor da História Comparada das Culturas, foi um pesquisador capaz de transitar com grande desembaraço, segurança e precisão nos mais diversos ramos das Ciências Humanas.
101 dias em Bagdá
Authors: Soares Marina
Published: December 2017

SEIERSTAD, Åsne. 101 dias em Bagdá. Rio de Janeiro: Record, 2006.
No entremeio do funcionamento do discurso do cordel: o ritmo e a estereotipia
Authors: D’Olivo Fernanda Moraes , Lagazzi Suzy
Published: December 2017

Este artigo apresenta uma análise do funcionamento da estereotipia e do ritmo na literatura de cordel. Tomamos como fundamentação teórica e metodológica a Análise de Discurso materialista. Para a constituição do corpus discursivo utilizamos folhetos nordestinos que retratam a figura feminina. Esses folhetos se encontram no acervo de Literatura de Cordel do CEDAE/UNICAMP. Compreendemos, nesta análise, que o entrecruzamento entre o ritmo e a estereotipia produz um efeito de ludicidade que permite que a moral, constitutiva dos discursos do cordel, circule mais facilmente entre os interlocutores.
Prohormones in the Early Diagnosis of Cardiac Syncope
Authors: Badertscher Patrick , Nestelberger Thomas , de Lavallaz Jeanne du Fay , Than Martin , Morawiec Beata , Kawecki Damian , Miró Òscar , López Beatriz , Martin‐Sanchez F. Javier , Bustamante José , Geigy Nicolas , Christ Michael , Di Somma Salvatore , Peacock W. Frank , Cullen Louise , Sarasin François , Flores Dayana , Tschuck Michael , Boeddinghaus Jasper , Twerenbold Raphael , Wildi Karin , Sabti Zaid , Puelacher Christian , Rubini Giménez Maria , Kozhuharov Nikola , Shrestha Samyut , Strebel Ivo , Rentsch Katharina , Keller Dagmar I. , Poepping Imke , Buser Andreas , Kloos Wanda , Lohrmann Jens , Kuehne Michael , Osswald Stefan , Reichlin Tobias , Mueller Christian
Published: December 2017

Background

The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope: midregional–pro‐A‐type natriuretic peptide (
MR
pro
ANP
), C‐terminal proendothelin 1, copeptin, and midregional‐proadrenomedullin.

Methods and Results

We prospectively enrolled unselected patients presenting with syncope to the emergency department (
ED
) in a diagnostic multicenter study.
ED
probability of cardiac syncope was quantified by the treating
ED
physician using a visual analogue scale. Prohormones were measured in a blinded manner. Two independent cardiologists adjudicated the final diagnosis on the basis of all clinical information, including 1‐year follow‐up. Among 689 patients, cardiac syncope was the adjudicated final diagnosis in 125 (18%). Plasma concentrations of
MR
pro
ANP
, C‐terminal proendothelin 1, copeptin, and midregional‐proadrenomedullin were all significantly higher in patients with cardiac syncope compared with patients with other causes (
P
<0.001). The diagnostic accuracies for cardiac syncope, as quantified by the area under the curve, were 0.80 (95% confidence interval [CI], 0.76–0.84), 0.69 (95%
CI
, 0.64–0.74), 0.58 (95%
CI
, 0.52–0.63), and 0.68 (95%
CI
, 0.63–0.73), respectively. In conjunction with the
ED
probability (0.86; 95%
CI
, 0.82–0.90),
MR
pro
ANP,
but not the other prohormone, improved the area under the curve to 0.90 (95%
CI,
0.87–0.93), which was significantly higher than for the
ED
probability alone (
P
=0.003). An algorithm to rule out cardiac syncope combining an
MR
pro
ANP
level of <77 pmol/L and an
ED
probability of <20% had a sensitivity and a negative predictive value of 99%.

Conclusions

The use of
MR
pro
ANP
significantly improves the early detection of cardiac syncope among unselected patients presenting to the
ED
with syncope.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
01548352.
The Rise of Capitalist Manufacture in the Ancien Régime
Authors: Heller Henry
Published: December 2017

Viewing the development of French trade and manufacturing between 1650 and 1820, Jeff Horn underscores their great success based largely on overseas markets. His evidence supports the view of Friedrich Engels and Perry Anderson that capitalism developed within the pores of the Old Regime. Yet Horn attempts to deny the leading role of the bourgeoisie in this advance. He claims that it was through the Old Regime system of economic privileges rather than the agency of bourgeois capital accumulation that such progress was made. This article rejects Horn’s exclusive preoccupation with the positive economic role of the privileges granted by the state. It reasserts the importance of the agency of the bourgeoisie in furthering economic development. Moreover, it contends that for all the economic gains made by the system of state privileges, such privileges were more than offset by the weight of rents on the peasantry and to the benefit of the nobility and Church imposed by this same regime of privileges. The distorted development that privileges imposed on economic and social life became an important factor behind the outbreak of the Revolution.
Strobilanthes jomyi (Acanthaceae), a remarkable new species from South India
Authors: BIJU PUNNAKOT , JOSEKUTTY ELAYANITHOTTATHIL JOSEPH , REKHA DAMODARAN , WOOD JOHN R.I.
Published: December 2017

A new species, Strobilanthes jomyi, is described and illustrated from Kerala, India. The new species is similar to S. ixiocephala in its spheroidal, echinulate pollen, but differs in its pendulous inflorescence, thinly hispid style, exserted stamens and 4-seeded capsule with entirely pubescent seeds. It is also similar to S. ciliata in the form of its inflorescence and exserted stamens and style, but differs in its ovate-elliptic leaves with crenate margin, hairy bracts and bracteoles, glandular-pubescent ovary and gland-tipped capsule, pubescent seeds and spheroidal, echinulate pollen. Its possible relationships are discussed based on its pollen and floral morphology.
Two new species of the genus Nemognathomimus (Coleoptera: Cerambycidae) from Mexico and Guatemala
Authors: GUTIÉRREZ NAYELI , NOGUERA FELIPE A.
Published: December 2017

Two new species of the genus Nemognathomimus Chemsak & Linsley are described and illustrated, Nemognathomimus wappesi sp. nov. from the Mexican states of Chiapas and Oaxaca and from Guatemala, and N. angelicae sp. nov. from the Mexican state of Hidalgo. A key to separate the species of Nemognathomimus is included.
The genus Antonia Loew in Egypt: A. gabalensis El-Hawagry, a new synonym of A. fedtschenkoi Loew (Antoniinae, Bombyliidae, Diptera)
Authors: EL-HAWAGRY MAGDI S.
Published: December 2017

Antonia gabalensis El-Hawagry, 2009 is hereby synonymized with Antonia fedtschenkoi Loew, 1873. Two homeotypes of A. fedtschenkoi and the primary types of A. gabalensis have been examined and found conspecific. Synonyms, diagnoses and photographs of dorsal habitus and male genitalia of the Egyptian species of Antonia are presented.
Additions to Idiostolidae in Coscarón (2017) “A catalogue of the Heteroptera (Hemiptera) or true bugs from Argentina”
Authors: FAÚNDEZ EDUARDO I.
Published: December 2017

Several references missing in the Idiostolidae chapter of the recently published Catalogue of the Heteroptera (Hemiptera) or true bugs from Argentina are provided. Annotations to the bibliography are provided to clarify some records of the family in the country.
DESENVOLVIMENTO HUMANO – REPENSANDO CONCEITOS NO ÂMBITO INTERDISCIPLINAR
Authors: De Moura Eliana Perez Gonçalves , Pereira Gislaine Cristina
Published: December 2017

O estudo do desenvolvimento humano, diante da constante e complexa transformação nos domínios teórico-práticos interdisciplinares, vem sendo pensado de maneiras diversas.  Apesar dos recursos financeiros continuarem sendo relevantes, o crescimento econômico deixa de ser primordial na composição deste conceito, sendo complementado pelo fator humano. O objetivo é apresentar um breve resgate compreensivo sobre desenvolvimento humano. Utiliza-se o método bibliográfico, com a busca através do descritor desenvolvimento humano, sendo direcionada para livros e periódicos científicos, publicados a partir de 1980, partindo do IDH / PNUD, para outras abordagens interdisciplinares. Percebe-se a importância de compreender o desenvolvimento humano para além dos aspectos econômicos, sem desconsiderar o IDH que contempla renda, saúde e educação. Conclui-se que a noção ampliada do termo destaca além destes indicadores os aspectos físico, cognitivo, psicossocial, histórico, cultural e principalmente subjetivo para a compreensão de desenvolvimento humano.
Cryoballoon Ablation in Today’s Practice: Can the Left Common Ostium Be Ablated and Injury to the Right Phrenic Nerve Avoided?
Authors: Chierchia Gian-Battista ,   Heart Rhythm Management Centre, University of Brussels, Brussels, Belgium, Iacopino Saverio ,   Electrophysiology Unit, Villa Maria Cecilia Hospital, Ravenna, Italy, Asmundis Carlo de ,   Electrophysiology Unit, Villa Maria Cecilia Hospital, Ravenna, Italy
Published: December 2017

Electrophysiology Unit, Villa Maria Cecilia Hospital, Ravenna, Italy
La higiene intelectual infantil o los comienzos de la psiquiatrización de la infancia en Colombia, 1888-1920
Authors: Vásquez María Fernanda
Published: December 2017

.
Drogas: entre cuerpos regulados y morales desviadas. Argentina, 1880-1960
Authors: Sánchez Antelo Victoria
Published: December 2017

.
Language and lifeworld: Schutz and Habermas on idealization
Authors: Strassheim Jan
Published: December 2017

***Linguagem e mundo-da-vida: Schutz e Habermas sobre idealização***Jürgen Habermas criticou Alfred Schutz de maneira seminal. Este artigo traça tal divergência até a diferença na conceitualização de idealização. A teoria social de Schutz é baseada em “tipos” enquanto idealizações com uma dinâmica inerente, enquanto a teoria social de Habermas é baseada em “regras” idealmente estáveis. Primeiramente, um modelo de regra de comunicação linguística é avaliado de acordo com análises da linguística, da filosofia e da sociologia da linguagem. É constatado que um modelo falha em alcançar seu objetivo teórico de explicar a comunicação linguística. Regras de linguagem hipotéticas, portanto, não explicariam nossa compreensão intuitiva de conteúdos proposicionais mínimos expressos em enunciados. As regras seriam tanto insuficientes quanto incertas em todas as instâncias do uso da linguagem. Neste contexto, a relação entre linguagem e “mundo-da-vida” é reavaliada. Um mundo-da-vida não pode ser constituído sobre um modelo de linguagem, nem mesmo suplementar tal modelo a fim de preservá-lo. Diferentemente de um modelo, Schutz reivindica que linguagem e mundo-da-vida estão interconectados e estruturados em “tipos” que podem acomodar a flexibilidade e a precisão da comunicação linguística. Embora seja necessário o aprofundamento da pesquisa, as conclusões apontam que a fenomenologia tem sido indevidamente negligenciada pela filosofia social, e deveria receber maior atenção, assim como tem recebido na sociologia.
The ecological epoché
Authors: Barber Michael
Published: December 2017

***A epoché ecológica***Na discussão de Afred Schutz sobre o mundo da vida cotidiana, que difere de outras realidades múltiplas, apesar de todas essas realidades pertencerem ao mundo da vida que antecede a implementação da redução fenomenológica completa, ele enfatiza que o mundo da vida cotidiana é um mundo de trabalho. Nesse artigo, descreverei o que é trabalhar e seu potencial para prejudicar/comprometer nossas relações com os animais e impactar de forma negativa a sustentabilidade ecológica. Então, sugerirei dois recursos da tradição fenomenológica para desafiar o potencial de tal comprometimento: a noção de empatia de Husserl, que atinge os animais, e a ideia de realidades múltiplas de Schutz, a qual, como argumentarei, poderia incluir uma atitude ecológica distinta iniciada por uma epoché ecológica.
Preparative separation of flavanones and terpenoids from olibanum by high-speed counter-current chromatography
Authors: Zhao H. W. , Geng Y. L. , Zhu H. , Yang P. , Yu J. Q.
Published: December 2017

Seven compounds, including two flavanones, dihydrokaempferol (1) and naringenin (2), and five terpenoids, boscartol A (3), 3,7-dioxo-tirucalla-8,24-dien-21-oic acid (4), 3α-acetoxyl-7-oxo-tirucalla-8,24-dien-21-oic acid (5), 11-keto-β-boswellic acid (6), and acetyl-11-keto-boswellic acid (7), have been purified by high-speed counter-current chromatography (HSCCC) from olibanum. For the separation, from 250 mg of the crude extract, 3.1 mg of 1 (95.2% purity), 2.7 mg of 2 (96.1% purity), 9.1 mg of 3 (96.7% purity), 4.5 mg of 4 (95.3% purity), 5.4 mg of 5 (96.3% purity), 48.1 mg of 6 (96.8% purity), and 45.5 mg of 7 (98.1% purity) were obtained by HSCCC with petroleum ether–ethyl acetate–methanol–water (1:0.8:1.1:0.6, v/v). The structures of these seven compounds were elucidated by a combination of electrospray ionization mass spectrometry (ESI–MS) and extensive nuclear magnetic resonance (NMR) spectroscopic.
Model energy cluster – special energy zone delivering integrated territorial energy
Authors: Gronkowska Joanna
Published: December 2017

Clusters constitute an organizational and economic phenomenon. Today, they are created in
nearly all sectors of the economy, including production industry, services, and high technology
industries. Act of 20 February 2015 on Renewable Energy Sources (RES Act, 2015) introduced
the term “energy cluster”. In the present article, we attempt to answer the question of how the
energy cluster can pursue, on a local level, the goal of ensuring energy security, while respecting
the requirements of environmental sustainability.
What do Flaubert, Dostoevsky and Machado de Assis have in common with neurology?
Authors: Vitturi Bruno Kusznir , Sanvito Wilson Luiz
Published: December 2017

ABSTRACT The Frenchman Gustave Flaubert, the Russian Fyodor Dostoevsky and the Brazilian Machado de Assis are known for their immeasurable contributions to literature. However, what most people do not know is that all three authors suffered from epilepsy and were affected by their neurological condition in different ways. We offer a short description of how epilepsy influenced their lives, how they dealt with it and how their neurological condition was present in their novels and correspondence. Their lives are excellent examples of how intimately neurology can be entwined in art and history, and provide an important perspective on patients with epilepsy.
Joinville stroke biobank: study protocol and first year’s results
Authors: Ferreira Leslie Ecker , França Paulo Henrique Condeixa de , Nagel Vivian , Venancio Vanessa , Safanelli Juliana , Reis Felipe Ibiapina dos , Furtado Luis , Martins Rui Kleber , Weiss Gustavo , Oda Elder , Lopes-Cendes Iscia , Pontes-Neto Octavio , Cabral Norberto Luiz
Published: December 2017

ABSTRACT Aiming to contribute to studies that use detailed clinical and genomic information of biobanks, we present the initial results of the first Latin American Stroke Biobank. Methods: Blood samples were collected from patients included in the Joinville Stroke Registry and four Brazilian cities. Demographic socio-economic data, cardiovascular risk factors, Causative Classification System for Ischemic Stroke, Trial of Org 10172 in Acute Stroke Treatment and National Institutes of Health scores, functional stroke status (modified Rankin) and brain images were recorded. Additionally, controls from both geographic regions were recruited. High-molecular-weight genomic DNA was obtained from all participants. Results: A total of 2,688 patients and 3,282 controls were included. Among the patients, 76% had ischemic stroke, 12% transient ischemic attacks, 9% hemorrhagic stroke and 3% subarachnoid hemorrhage. Patients with undetermined ischemic stroke were most common according the Trial of Org 10172 in Acute Stroke Treatment (40%) and Causative Classification System for Ischemic Stroke (47%) criteria. A quarter of the patients were under 55 years of age at the first-ever episode. Conclusions: We established the Joinville Stroke Biobank and discuss its potential for contributing to the understanding of the risk factors leading to stroke.
O PERFIL DA PESQUISA ACADÊMICA SOBRE EDUCAÇÃO A DISTÂNCIA NO BRASIL E NO MUNDO
Authors: Pelegrini Thalita de Oliveira , Silva Sheila Serafim da , Azevedo-Ferreira Maxwel de , Oliveira Murilo Alvarenga
Published: December 2017

RESUMO A Educação a Distância (EaD) ganhou destaque com o avanço das tecnologias, fazendo com que muitos pesquisadores se voltassem para o tema. A partir disso, justifica-se a importância de compreender a dinâmica do campo de estudo sobre EaD para o avanço da ciência e identificação de lacunas e vieses na produção do conhecimento. Este estudo teve como objetivo analisar o perfil internacional da pesquisa acadêmica sobre EaD e, mais especificamente, a participação brasileira nessas pesquisas. Foram utilizadas técnicas bibliométricas, visto que os indicadores da produção científica retratam o desenvolvimento de uma área do conhecimento. O estudo combinou os termos “Distance Education”, “E-learning” e “Elearning” na base de dados Web of Science (WoS). Realizaram-se os seguintes procedimentos: (1) definição dos termos mais adequados para a extração de dados de artigos relativos ao interesse da pesquisa; (2) busca e extração nas bases de dados; (3) limpeza e organização dos dados e (4) análises bibliométricas e interpretação. Os resultados apontaram que o tema é de interesse global e apresenta interação entre alguns países, com destaque para os Estados Unidos, como o país que mais publicou sobre o tema. A EaD está sendo pesquisada por um número considerável de autores que, juntos, somam 17.789, indicando que o tema está caminhando para maturidade no que diz respeito à análise internacional. Os resultados apontaram, ainda, que as publicações sobre EaD no Brasil possuem cooperação internacional, podendo ser um indicativo de que o Brasil está publicando com os principais países que pesquisam sobre o tema. A partir dessas evidências, a pesquisa pôde contribuir com o mapa do perfil da pesquisa acadêmica sobre EaD no Brasil e no mundo que pode ser útil aos pesquisadores da área.
QUALIDADE DE VIDA NO SERVIÇO PÚBLICO: UMA AVALIAÇÃO EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR
Authors: Klein Leander Luiz , Lemos Ricardo Brião , Pereira Breno Augusto Diniz , Beltrame Gabriela
Published: December 2017

RESUMO Na área da gestão de pessoas, o estudo da Qualidade de Vida no Trabalho (QVT), por envolver vários aspectos, tem se tornado um fator estratégico para melhorar a produtividade interna nas organizações. O presente estudo tem como objetivo analisar os fatores direcionadores da QVT, com base na percepção de servidores de uma organização pública. A base teórica se constituiu de conceitos e modelos sobre a QVT e do modelo de Ferreira (2011), que foi tomado como base para o desenvolvimento da pesquisa empírica. O método deste trabalho é uma pesquisa survey realizada por meio = de um questionário. A população são os servidores docentes e técnicos administrativos de uma universidade federal de ensino superior do interior do estado do Rio Grande do Sul. Conseguiu-se 474 questionários respondidos, o que corresponde a um erro amostral de 4,59%. Para a mensuração da opinião dos servidores utilizou-se uma escala do tipo Likert de cinco pontos. A análise de dados foi realizada por meio de estatística descritiva e estatística multivariada. Como principais resultados pode-se destacar o alcance de 9 fatores obtidos através da análise fatorial exploratória. Para investigar a influência dos fatores encontrados sobre a QVT, realizou-se uma regressão linear múltipla e verificou-se que os fatores Satisfação no Trabalho, Espaço Físico, Oportunidade de Crescimento Profissional e Relacionamento com os Colegas explicam 54,6% do modelo do estudo. Com a discussão feita sobre os resultados obtidos, conclui-se que o impacto desses fatores não se limita somente a uma melhora na qualidade de vida dos trabalhadores, mas também na produtividade, no comprometimento no trabalho, na saúde do trabalhador e na redução do absenteísmo.
Microwave-assisted extraction in dry fruit of andean species Vaccinium meridionale: Experimental conditions on the recovery of total polyphenols
Authors: Espinosa Wilfred Edilberto , Garzón Luis Carlos Arturo , Medina Oscar Julio
Published: December 2017

ABSTRACT Due to their nutraceutical properties, the fruits of the species Vaccinium meridionale, which inhabit the Andean region, are of scientific interest. Microwave-assisted extraction has been applied to different vegetal matrices for to extract efficiently polyphenolic compounds. In this work we study in microwave assisted extraction processes, the effect on the extraction of total polyphenols in dried fruits of Vaccinium meridionale, using response surface methodology. The main objective of this research was to analyze the relationships between power, temperature, solid-liquid ratio, time and ethanol concentration in aqueous media on the effectiveness of total polyphenols recovery in dry fruits of Vaccinium meridionale. A central composite design face-centered with three levels for each variable was used: P = 300 - 900 W; T = 70 -110 °C; L:Srat. = 30:1 - 70:1 w/w; t = 5 - 15 min; [EtOH] = 0 - 80%. In this sense, the effect of the input variables on the recovery of total polyphenols, the optimization process for maximum extraction, and the comparison to other solid-liquid extractions in terms of quantity of total polyphenols, are reported. It was found that the significant variables in the extraction process were ethanol concentration, temperature and time; the best yields were obtained in the range [EtOH] = 44 - 49%, T = 110 °C, and t = 10 - 15 min. In terms of quantity, time and consumption of energy, microwave-assisted extraction technique is more efficient than other solid-liquid extraction processes for the extraction of total polyphenols.
Ocimum basilicum essential oil combined with deltamethrin to improve the management of Spodoptera frugiperda
Authors: Silva Sérgio Macedo , Cunha João Paulo Arantes Rodrigues da , Carvalho Stephan Malfitano de , Zandonadi César Henrique Souza , Martins Rafael Castro , Chang Roberto
Published: December 2017

ABSTRACT For an important and expensive crop such as corn, the resistance of Spodoptera frugiperda J.E. Smith to various pesticides has led to research throughout the world for a potential insecticide from a natural source. For the management of pest resistance, natural compounds associated with synthetic insecticides can be a promising tool because they can reduce the application of the synthetics molecules while maintaining their effectiveness and promoting the control of the pests. Linalool is a potential insecticide that is easily obtained because it is found in high concentrations in the essential oil of Ocimum basilicum L. Therefore, the present study aimed to evaluate the toxicity of this essential oil and its combination with deltamethrin to control S. frugiperda. Through dose response assays, the acute toxicities (LD50) of the essential oil and deltamethrin were estimated. Additionally, the combination of these materials was also assessed, attaining a reduction of 80% of the LD50 of deltamethrin while obtaining the same result as when the pyrethroid was administered alone. From these results, it is expected that the combination of natural compounds and synthetic insecticides will be a promising practice, helping to manage resistance while reducing the environmental impact of toxic compounds.
Common mental disorders in medical students: A repeated cross-sectional study over six years
Authors: Costa Edméa Fontes de Oliva , Mendes Carlos Mauricio Cardeal , Andrade Tarcísio Matos de
Published: December 2017

Summary Introduction: Becoming a medical doctor is a very complex process. Factors related to the student’s personality, the educational process and the daily experience with death contribute to peculiar psycho-emotional experiences, not always properly investigated during medical training. Objective: To estimate the prevalence of common mental disorders (CMD) and associated factors, over six years of medical undergraduate course among all students of a class at a public university in Brazil. Method: Cross-sectional study based on repeated surveys. All 40 students enrolled in 2006 in the first year of our medical school were included and evaluated annually until 2011 using the SRQ-20 and a structured questionnaire prepared by the authors on sociodemographic, personal and educational aspects. We performed logistic regression and correspondence analysis. Results: The 40 freshmen in the first evaluation had a mean age of 20 years (SD=2.4), 57.5% were female, and 41% were approved after taking their third entrance exam. The prevalence of CMD increased over the years: from 12.5% in the first year to 43.2% in the fifth. The following variables were potentially associated with CMD: female sex (PR=1.38), originating from capital cities (PR=1.97), the program was less than they expected (PR=3.20), discomfort with program activities (PR=2.10), dissatisfaction with teaching strategies (PR=1.38), and feeling that the program is not a source of pleasure (PR=2.06), being R2=28.8% and AIC=60.04. Conclusion: The factors potentially associated with the high prevalence of CMD were those related to medical training, showing that it is necessary to implement preventive measures and review the educational process in order to reduce the damages caused by the development of CMD.
Formulação de Problemas Matemáticos de Estrutura Multiplicativa por Professores do Ensino Fundamental
Authors: Spinillo Alina Galvão , Lautert Sintria Labres , Borba Rute Elizabete de Souza Rosa , Santos Ernani Martins dos , Silva Juliana Ferreira Gomes da
Published: December 2017

Resumo O presente estudo investiga como professores do Ensino Fundamental concebem e formulam situações-problema inseridas no campo conceitual das estruturas multiplicativas. Trinta e nove professores do 1° ao 9° ano de escolas públicas foram solicitados a formular problemas matemáticos que pudessem ser resolvidos por meio de multiplicação e/ou de divisão. Os resultados mostram que os professores investigados compreendem o que uma situação multiplicativa significa e formulam problemas apropriadamente, sendo poucos os enunciados em que se omitem informações ou que apresentam imprecisões linguísticas. Verificou-se que a maioria dos problemas era de um mesmo tipo e envolviam apenas um passo para sua resolução. A pouca variabilidade foi observada em relação a todos os professores, independentemente do ano em que lecionavam. Concluiu-se que os professores têm dificuldade em formular problemas que envolvam diferentes relações no âmbito das estruturas multiplicativas, sendo necessário desenvolver no professor do Ensino Fundamental a habilidade de formular problemas.
Didática e formação de professores: provocações
Authors: Gatti Bernardete A.
Published: December 2017

RESUMO Este artigo discute as principais questões que as pesquisas atuais têm levantado sobre a formação de professores e traz reflexões a respeito das demandas da escolarização na contemporaneidade. Com essa contextualização, abordam-se documentos oficiais que, a partir de 2015, foram exarados para orientar a formação de docentes para a educação básica, considerando particularmente o novo Plano Nacional de Educação e os documentos do Conselho Nacional de Educação, a saber: o Parecer CNE/CP n. 2/2015 e a Resolução n. 2/2015. Explora- -se o que, nesses documentos, refere-se aos conhecimentos do campo da Didática.
Os indígenas na cartografia da América lusitana
Authors: Souto Alanna
Published: December 2017

Resumo Na cartografia realizada a partir da conquista colonial da América lusitana e da Amazônia, foram recorrentes as representações indígenas, como forma de reinventar e de localizar os povos nativos. Muitas vezes, essas representações eram pictóricas, com forte presença de elementos figurativos e de ornamentos, aspectos particulares ao período dos anos Quinhentos aos Setecentos. Contudo, na era pombalina (1750-1777), houve mudança nas representações cartográficas e nos valores estéticos relativos à simplicidade. Logo, a simetria na composição dos mapas passou a sobressair em detrimento da ornamentação. Os indígenas pouco apareciam na produção cartográfica, a não ser quando eram indicadas, nominalmente, as povoações e as aldeias estabelecidas dentro da nova configuração territorial resultante das reformas pombalinas, as quais fundaram administrativamente vilas, lugares, freguesias e povoações ou, economicamente, fazendas, engenhos, roças e terrenos. Essa nova ordem colonial intensificou os processos de desterritorialização e de reterritorialização das sociedades indígenas na Amazônia, que, de maneira diversa, se relacionaram às conquistas portuguesas (e espanholas). O objetivo deste artigo é discutir as representações indígenas no âmbito do espaço (chamado de concebido) da Amazônia colonial, por meio da investigação dos mapas coloniais, na perspectiva teórico-metodológica da cartografia histórica.