bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study on autonomic dysfunction in idiopathic generalized epilepsy
Authors: Thejesh C. V. , Nagashree V. , Nemichandra S. C. , Harsha S. , Shasthara P.
Published: February 2025

Objectives

Autonomic nervous system symptoms are frequently observed in patients with epilepsy. Our objective was to investigate the alterations in autonomic function in idiopathic generalized epilepsy (IGE) patients compared to age- and sex-matched Patients without Epilepsy (PwoE).

Materials and Methods

Thirty patients with epilepsy who had the disease for 6 months–15 years and were controlled or partially controlled with antiepileptic medications, along with a group of healthy PwoEs, underwent Autonomic Function Tests after providing informed consent. The tests measured heart rate variability and blood pressure (BP) responses, and the results were statistically analyzed using Ewing’s and Bellavere’s criteria to classify cardiac autonomic neuropathy (CAN).

Results

The two groups were demographically comparable. Abnormal breathing patterns, abnormal Valsalva ratios, abnormal hand grip test results, and abnormal BP response were more prevalent in the people with epilepsy (PwE) group than in the PwoE group, and these were statistically significant. There were 18 (60.0%) subjects in the PwE group and none in the PwoE in the definite CAN category (score 4–6). Early CAN was noted in both groups but was slightly more prevalent in the PwE group. Most patients (50.0%) were undergoing treatment for periods ranging from 1 to 2 years, and levetiracetam was the most commonly used anti-seizure medication (ASM). Valproate was associated with the highest proportion of abnormal CAN, followed by levetiracetam and phenytoin.

Conclusion

This study demonstrates that patients with IGE exhibit a significantly higher prevalence of autonomic dysfunction compared to healthy PwoEs, drawing attention to the need for further investigation into the underlying mechanisms and clinical implications.
Preliminary results of clinical assessment of correction of high refractive errors with using phakic intraocular lenses
Authors:   Republican Specialized Scientific and Practical Medical Center of Eye Microsurger y, Tashkent, Uzbekistan, Zaynutdinov N.N. , Yusupov A.F. ,   Republican Specialized Scientific and Practical Medical Center of Eye Microsurger y, Tashkent, Uzbekistan, Karimova M.K. ,   Republican Specialized Scientific and Practical Medical Center of Eye Microsurger y, Tashkent, Uzbekistan, Kamilov K.M. ,   Center for the Development of Professional Qualifications of Medical Workers, Tashkent, Uzbekistan
Published: February 2025

Purpose. To evaluate initial clinical outcomes after implantation phakic IOLs (ICL and toric ICL) to patients with high refractive errors during next post-op 6 months period.

Material and methods. In this retrospective, observational study, 112 eyes of 60 patients had been investigated after implantation VICM5 and VTICM5 models of phakic IOLs. In early stages of investigation, the main clinical outcomes of this study were uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), ICL vault, intraocular pressure, and development of any kind early post-op complications. In this study, safety and efficacy indexes and all patients’ postoperative outcomes have been evaluated at 1 day, 1 week, 1, 3 and 6 months in post – operative period.

Results. Totally 112 eyes of 60 patients had underwent VICM5 and VTICM5 models of PIOL implantation in NAZAR Eye Center from January 2020 to December 2022. These patients had been divided into two groups. The first group A has contained 30 patients with 58 eyes (the mean age of patients was 27.52±6.61). In this group, the mean preoperative manifest spherical equivalent (MSE) was –10.59±3.41 D and manifest cylinder (MC) was –1.29±0.51 D respectively, which postoperative spherical refractive measures reduced to –0.92±0.37 D and cylinder measures reduced to –0.77±0.39 D. The second group B has contained 30 patients with 54 eyes (the mean age of patients was 28.34±6.64). In this group, the mean preoperative manifest spherical equivalent (MSE) was –9.85±2.65 D and manifest cylinder (MC) was –3.19±0.79 D respectively, which postoperative spherical refractive measures reduced to –1.18±0.56 D and cylinder measures reduced to –0.53±0.1 D. The mean IOP was 16.30±1.85 mmHg preoperatively. The mean IOP has changed until 15.44±1.76 mmHg during six months post-op period.

Conclusion. Spheric models of phakic IOLs VICM5 and and toric VTICM5 ICL implantation are a safe, effective and alternative refractive surgery for correction of high refractive errors (high myopia and myopic astigmatism) for patients with thin cornea and several contraindications for laser correction.

Key words: high refractive errors, phakic intraocular lens, implantable collamer lens, visual acuity, high myopia, intraocular correction, intraocular pressure
On the Organization of Ophthalmological Care for Patients in the Lipetsk Region
Authors:   First Moscow State Medical University named after I.M. Sechenov of the Ministr y of Healthcare of the Russian Federation (Sechenov University), Moscow, Russia, Osmanov E.M. ,   Tambov Regional Children’s Clinical Hospital, Tambov, Russia, Efimov D.V. ,   Prozrenie, Lipetsk, Russia
Published: February 2025

Purpose. To compare the organization of ophthalmological care for patients in medical organizations of the Lipetsk region of state and private ownership.

Material and methods. The study was conducted at the Department of Public Health and Healthcare of the F.F. Erisman Institute of Public Health of Sechenov University. Statistical information is provided by the territorial fund of compulsory medical insurance of the Lipetsk region (https://www.ofoms48.ru) for 2014–2021.

Results.  Over the analyzed period, a decrease in the number of state medical organizations (MO) providing primary specialized medical care (MP) to the population of the Lipetsk region in the ophthalmology profile was established with a simultaneous increase in the number of private ophthalmological offices and clinics. In state MO, the relative share of cases of outpatient MP and especially MP within day hospitals (DS) in the ophthalmology profile decreases with an increase in private MO. In 2014, the share of MP cases in DS in private MO was 2.3%, in 2021 already 58.1%, compared to state MO. The most expensive inpatient ophthalmological care is provided in two state and two private MO, and in the latter, only 33 cases during the studied period, due to the high level of possibility of organizing ophthalmological care in DS, which is most preferable for private MO.

Conclusion. The current situation in the region with MP for the population in the ophthalmology profile is due to the influence of both difficult-to-manage socio-economic determinants and manageable problems in the system of organizing the provision of MP.

Key words: ophthalmological care, medical care, ophthalmological offices, private medical organizations, Lipetsk region
Estimates on the Number of People Blind and Visually Impaired Due to Age-Related Macular Degeneration in Southern Urals
Authors:   Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia, Bikbov M.M. , Iakupova E.M. ,   Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia, Kazakbaeva G.M. ,   Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia, Panda-Jonas S. ,   Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany,   Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France,   Privatpraxis Prof Jonas und Dr. Panda-Jonas, Heidelberg, Germany, Bourne R. ,   Vision & Eye Research Unit, Anglia Ruskin University, Cambridge, United Kingdom, Gilmanshin T.R. ,   Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia, Jonas J.B. ,   Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France,   Privatpraxis Prof Jonas und Dr. Panda-Jonas, Heidelberg, Germany,   Singapore Eye Research Institute, Singapore National Eye Center, Singapore,   Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China,   New York Eye and Ear Infirmar y of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Published: February 2025

Purpose. To analyze the prevalence of blindness and vision impairment due to age-related macular degeneration.

Material and methods. In the period from 2015 to 2017, cross-sectional clinical and population study Ural eye and Medical Study (UEMS) were conducted at the Ufa Research Institute.

Results. Among individuals with moderate to severe vision impairment, late stage of age-related macular degeneration was the cause of vision impairment in 14 respondents (7.7%; 95% CI: 3.8–11.6), among whom geographic atrophy was noted in 7 (3.8%; 95% CI: 1.0–6.7) people. Among individuals suffering from blindness, AMD as the main cause of vision loss was identified in 2 respondents (18.2%; 95% CI: 3.2–52.2). The proportion of individuals has moderate to severe vision impairment due to age-related macular degeneration in the study population was 0.24% (95% CI: 0.14–0.41), The proportion of people who became blind due to age-related macular degeneration was 0.03% (95% CI: 0.01–0.14).

Conclusion. In the population of the Southern Urals, the prevalence of moderate and severe visual impairment due to age-related macular degeneration was 0.24% (95% CI: 0.14–0.41), blindness – 0.03% (95% CI: 0.01–0.14). The data obtained are comparable with those among the regions of the world and the world population as a whole.

Key words: clinical and population studies, age-related macular degeneration, vision impairment, blidness
Pathogenetic and clinical aspects of neovascular and phacogenic secondary (refractory) glaucoma
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russia, Sorokin E.L. ,   Far-Eastern State Medical University, Khabarovsk, Russia, Baranova K.M. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russia
Published: February 2025

The purpose of this review is to consider neovascular and phacogenic types of secondary glaucoma that ophthalmologists have to deal with in their daily clinical practice for effective identification of the risk group, for the purpose of prevention, slowing down progression, as well as maintaining visual functions and quality of life of the patient. The review was written by using the domestic RSCI database and the international PubMed database, the search keywords were «secondary glaucoma», «neovascular glaucoma», «phacogenic glaucoma», «phacotopic glaucoma», «phacomorphic glaucoma», «phacotoxic glaucoma», «phacolytic glaucoma». An analysis of 44 literature sources was performed. The search depth was 23 years (2001–2024). The article highlights the issues of classification of secondary phacogenic and neovascular glaucoma. It was revealed that practicing opthalmologists more often use the clinical classification of secondary glaucomas proposed by A.P. Nesterov. Emphasis is placed on the issues of pathogenesis, clinical presentation and differential diagnostic features of neovascular and phacogenic glaucoma, which are distinguished by a variety of etiopathogenetic mechanisms of development and clinical manifestations.

Key words: secondary glaucoma, classification of secondary glaucoma, neovascular glaucoma, phacogenic glaucoma
Rola i wyzwania prawa własności intelektualnej we wspieraniu innowacyjności i konkurencyjności przedsiębiorstw
Authors: Ratajczak Weronika
Published: February 2025

W artykule przedstawiono rolę prawa własności intelektualnej we wspieraniu innowacyjności oraz konkurencyjności przedsiębiorstw, zwracając uwagę na wyzwania, jakie niesie ze sobą dynamicznie zmieniające się środowisko biznesowe. Własność intelektualna, obejmująca patenty, znaki towarowe czy prawa autorskie, stanowi fundament strategii ochrony innowacji w firmach, takich jak Adidas, Tesla czy LEGO. Przykłady te ilustrują, jak różnorodne formy ochrony mogą zabezpieczać technologie, marki i innowacyjne rozwiązania, przyczyniając się do uzyskania przewagi konkurencyjnej na rynku. Artykuł jest też próbą odpowiedzi na pytanie, w jaki sposób prawo własności intelektualnej wpływa na zarządzanie innowacjami, umożliwiając przedsiębiorcom skuteczne zabezpieczanie ich rozwiązań technologicznych oraz wspierając rozwój nowych produktów i usług. W kontekście globalnej rywalizacji ochrona własności intelektualnej staje się niezbędnym narzędziem dla firm, które pragną umacniać swoją pozycję na rynku. Efektywne zarządzanie prawami własności intelektualnej może zwiększyć wartość przedsiębiorstwa, przyciągnąć inwestorów oraz przeciwdziałać zagrożeniom związanym z piractwem i kopiowaniem treści w erze cyfrowej.
Przemoc rówieśnicza jako wyzwanie dla systemu oświaty w Polsce
Authors: Sztajnkowska Roksana , Milczarczyk Natalia
Published: February 2025

Badanie nad przemocą rówieśniczą w Polsce bada przyczyny, skutki i rozwiązania tego problemu w systemie edukacyjnym. Wskazuje na głęboko zakorzenione źródła przemocy wśród uczniów, takie jak środowisko rodzinne, sytuacje społeczne i wzorce komunikacyjne. Analiza obejmuje różne formy przemocy rówieśniczej, takie jak agresja fizyczna i cyberprzemoc, każda z odrębnymi konsekwencjami dla ofiar. Badanie podkreśla, że przemoc wynika ze złożonych interakcji między cechami indywidualnymi, czynnikami środowiskowymi i normami społecznymi. Efektywna prewencja i interwencja wymagają współpracy rodzin, szkół, lokalnych społeczności i instytucji. Proponowane środki obejmują edukację, wsparcie psychologiczne oraz zwiększenie świadomości na temat przemocy rówieśniczej. Badanie akcentuje potrzebę podejścia holistycznego, angażującego wiele sektorów społecznych w celu kompleksowego rozwiązania problemu i zmniejszenia jego rozpowszechnienia w polskich szkołach.
Usługi leśne w systemie produktowo-usługowym
Authors: Chrulski Zbigniew , Puchała Maciej
Published: February 2025

W artykule przybliżono wybrane zagadnienia dotyczące definicji systemów produktowo-usługowych oraz ich powiązania z usługami leśnymi. Zaprezentowano także specyfikę zakładów usług leśnych. Omówiono podstawowe różnice w zakresie maszyn leśnych. Zastosowanie nowoczesnych maszyn leśnych jest niezbędnym aspektem rozwoju technicznego i organizacyjnego, mającym na celu poprawę poziomu bezpieczeństwa pracy w lasach oraz podniesienie jakości wykonywania prac leśnych. Podano przykładową analizę dwóch maszyn leśnych niezbędnych w pracach związanych ze zrębkowaniem pozyskanego materiału drzewnego.
Intralogistyka w literaturze przedmiotu
Authors: Osieczko-Potoczna Kornelia
Published: February 2025

Artykuł dotyczy intralogistyki, nowej dziedziny logistyki związanej z organizacją, zarządzaniem i optymalizacją wewnętrznego przepływu materiałów, informacji i usług w przedsiębiorstwach produkcyjnych, handlowych oraz instytucjach publicznych. Przedstawiono rozwój logistyki, podkreślając znaczenie technologii Przemysłu 4.0, automatyzacji i cyfryzacji procesów. Przeanalizowano, jak intralogistyka wykorzystuje nowoczesne systemy, takie jak systemy magazynowe, transportowe oraz oprogramowanie (ERP, WMS), aby zwiększyć efektywność i produktywność. Artykuł wskazuje na rosnącą rolę tej dziedziny w optymalizacji procesów logistycznych i sugeruje potrzebę dalszych badań nad jej rozwojem i wpływem na organizacje. W artykule wykorzystano metodę analizy literatury.
The impact of hotel companies' ESG promotional videos on brand preference and purchase intention: focusing on differences based on ESG beliefs
Authors:   The Table and Food Coordinate Society of Korea, Lee Eun-Yong , Kim Seong-Yeong , Park Kyu-Eun
Published: February 2025

The objective of this study was to understand how viewing hotel ESG promotional videos affects customer brand preferences and purchase intentions. Furthermore, based on the disparities in customer ESG beliefs, an attempt was made to study any changes that occurred in customer opinion and preference after watching the ESG promotional material. Accordingly, two representative hotel companies that conduct ESG activities in Korea were selected. Brand preference and purchase intention were then measured before and after watching ESG videos to verify any changes. Analysis demonstrated that customer brand preference and purchase intention for hotels increased after watching the promotional video. Further analysis determined that there was no difference between hotel companies. Moreover, according to customer ESG beliefs, the difference in customer opinion and intent before and after watching the video was verified through multivariate analysis of variance. As a result of the analysis, a greater change was found in the group with high ESG beliefs. Therefore, it was determined that effectively promoting hotel ESG activities has a positive effect on customers making purchasing decisions. These results indicate that a strategic plan needs to be put in place to continue influencing customers positively. Thus, initiatives are needed to conduct more intensive promotional activities for groups with high ESG beliefs. Through such research, it is believed that it will be of practical use in increasing sales and devising strategic plans in the fiercely competitive hotel business environment.
Application methods according to the process stages of food styling based on generative AI technology
Authors:   The Table and Food Coordinate Society of Korea, Chang Heajin , Kim Sungah
Published: February 2025

Focusing on AI-driven image generation, this study explored the application of generative AI to enhance efficiency and innovation in food styling workflows. Through case analysis and practical application, we examined AI's potential across four key stages of the food styling process: (1) Planning stage (chatbot training): Based on image and text inputs, AI chatbots assist in brainstorming and concept development; (2) Idea Structuring stage (prompt design): Expert-driven prompt engineering is crucial for generating high-quality outputs; (3) Food Styling stage (image generation): Based on provided prompts, AI tools generate images; and, (4) Completion stage: To achieve the desired aesthetic, generated images are modified and combined. This research highlights the importance of AI literacy for food stylists and promotes interdisciplinary collaboration. While demonstrating AI's potential to streamline workflows and foster creativity, this study also acknowledges current limitations, including the reliability of AI-generated content and the need for ethical considerations in its application. This approach aims to provide valuable insights for researchers and future food stylists navigating the evolving landscape of digital food styling.
Analysis of selection attributes for K-food specialty restaurants using modified IPA
Authors:   The Table and Food Coordinate Society of Korea, Kim Mi-Yeon , Na Hyun soo , Hwang Mi Yeon
Published: February 2025

This study aims to systematically analyze consumer choice attributes and propose strategic directions to enhance the competitiveness of tteokbokki specialty restaurants in the K-food market. A survey was conducted with 224 consumers who visited tteokbokki specialty restaurants in the Seoul and Gyeonggi regions, and data were analyzed using the Modified Importance-Performance Analysis (Modified IPA) method. The results indicate that consumers perceive taste, aroma, and service speed as the most critical choice attributes, all of which exhibited high relative importance and satisfaction levels, establishing tteokbokki as a key dish of K-food. Meanwhile, store cleanliness, exterior design, and background music were identified as attributes with high importance but low satisfaction, indicating the need for improvement. Enhancing menu quality, providing prompt service, maintaining systematic hygiene management, and creating a sensory-driven store environment are essential to optimizing consumer experiences. Accordingly, strategies such as differentiated recipes, improved order processing systems, staff training programs, enhanced hygiene management, brand identity establishment, and sensory marketing are recommended to strengthen competitiveness. Furthermore, as tteokbokki serves as a cultural medium for experiencing Korean cuisine, integrating K-content with brand marketing and experiential promotions is necessary. By systematically analyzing the gap between consumer expectations and actual experiences, this study provides practical implications for service improvement and brand differentiation strategies in K-food specialty restaurants. The findings can serve as foundational data to support the continued growth of K-food establishments in the global market.
Neural Mulliken Analysis: Molecular Graphs from Density Matrices for QSPR on Raw Quantum-Chemical Data
Authors: Gromov Oleg
Published: February 2025

Here molecular graphs derived from the 1-electron density matrix are introduced within a more general effort to explore whether electronic structure awareness allows combining generalization from small data and optimal feature learning in a single model. Diagonal matrix blocks serve as atomic nodes embeddings, off-diagonal blocks provide embeddings for “link” nodes in-between atomic pairs. In a minimal basis, these embeddings have dimensions of only 45 and 81, still no data loss occurs. The overlap matrix is used in edge embeddings to encode structural information and as weights for pooling operations. Additionally, element-wise multiplication performed while pooling may provide access to electronic charges similar to Mulliken population analysis. A GNN trained on 94 drug-like molecules from the Solubility Challenge (2008, Llinàs et al.}) demonstrated improved solubility prediction accuracy (RMSE 0.63, R2 0.79). If combined with existing techniques for predicting electron density from molecular structure, this approach is promising for addressing various chemical machine-learning problems.
An In-Silico Study on Transient Enzyme Diffusion and Adsorption within Lignocellulosic Biomass using a Multi-Scale Model
Authors: Merugu Saketh , Shonnard David
Published: February 2025

Diffusion of hydrolytic enzymes into biomass particles is a potential limiting step, which has yet to be studied in detail separate from intrinsic hydrolysis kinetics. We developed and applied a pore-enzyme diffusion model for both adsorbing and non-adsorbing enzymes and coupled them to reactor-level mass balance equations. With this multi-scale model, the effects of biomass particle porosity, size, and adsorption capacity on the characteristic time of enzyme diffusion and adsorption were predicted over an expected range of these parameters. Using a hydrolysis limiting threshold characteristic time for enzyme diffusion of 6 hours, this model mapped the transport parameter space between two distinct zones: diffusion limiting and non-diffusion limiting. The model also predicted a decrease in characteristic time with an increase in the biomass-to-enzyme loading ratio. At the particle level, characteristic time was most strongly affected by firstly adsorption capacity, then particle radius, adsorption affinity, and porosity.
Immunological predictors of the therapeutic efficacy of atezolizumab in combination with nab-paclitaxel in metastatic triple-negative breast cancer: A pilot multicenter retrospective associative study
Authors: Kalinchuk Anna Yu. , Popova Nataliya O. , Gofman Alina A. , Usoltseva Inessa S. , Perelmuter Vladimir M. , Tashireva Liubov A.
Published: February 2025

Background. Chemoimmunotherapy with the combination of atezolizumab and nab-paclitaxel demonstrates clinical benefit at 12 months in only 45.8% of patients with metastatic triple-negative PD-L1-expressing breast cancer. This emphasizes the relevance of finding predictor markers of high sensitivity to immunotherapy. Since atezolizumab acts through the local immune system, assessing its status prior to therapy administration may be crucial.
Aim. The objective of this study was to evaluate the predictor significance of immunological parameters of tumour microenvironment in patients with metastatic triple-negative cancer receiving therapy with atezolizumab in combination with nab-paclitaxel.
Materials and methods. Eleven patients with metastatic triple-negative breast cancer, who received atezolizumab in combination with nab-paclitaxel, were included in the study. Among them, five patients exhibited a durable response (progression-free survival 6 months), while six patients had a short response (progression-free survival ≤6 months). Tumour microenvironment parameters (the proportion of immune cells in the microenvironment and their expression of PD-L1 and PD-1) were analyzed by TSA-associated multiplex immunofluorescence (Tyramide Signal Amplification) using the Vectra® 3.0 tissue analysis system and InForm® software (Akoya Bio, USA).
Results. The study revealed that CD163+-macrophage counts below 6.475% of all tumor stromal cells were associated with long-term efficacy of atezolizumab in combination with nab-paclitaxel in patients with metastatic triple-negative cancer.
Conclusion. The number of CD163+-macrophages in the tumor stroma could potentially serve as a marker for predicting the efficacy of atezolizumab in combination with nab-paclitaxel in patients with metastatic triple-negative cancer.
The reasons for prescribing antitumor drugs beyond the registered indications in real clinical practice: A retrospective study
Authors: Karabina Elena V. , Sakaeva Dina D. , Lipatov Оleg N.
Published: February 2025

Aim. To study the reasons for prescribing antitumor drugs (ATDs) beyond the registered indications (BRIs) in real clinical practice.
Materials and methods. The study was conducted at the Tula Regional Clinical Oncology Center. For 6 months of 2019, information was analyzed on 919 completed cases of treatment of 201 patients over the age of 18 who received antitumor drug therapy for morphologically verified solid malignant neoplasms in the inpatient department of the medical organization using a regional information system. Completed cases of treatment with ATDs were copied BRIs and in accordance with the registered indications. The analysis of the literature devoted to the study of the causes of the use of ATDs outside the registered indications has been carried out. The reasons for prescribing ATDs BRIs in real clinical practice were studied when analyzing completed cases of treatment of patients receiving appropriate therapy.
Results. In 86.2% of cases, the main reason for the use of antitumor drug therapy BRIs is associated with the presence of antitumor agents in clinical guidelines and recommendations of professional communities. 11.6% of cases of prescribing antitumor agents BRIs were associated with burdened clinical situations: exhaustion of the possibilities of registered therapy; lack of treatment options for rare forms of neoplasms; lack of alternative options with contraindications to standard treatment methods. Other reasons for prescribing the above mentioned treatment were extremely rare and were situational in nature.
Conclusion. In the vast majority of cases, the main reason for prescribing ATDs BRIs is the presence of these agents in clinical guidelines and recommendations of professional communities. The second most common cause is associated with burdened clinical situations. The information obtained indicates that the use of ATDs in cancer patients is an integral part of routine clinical practice and in the future can be used to improve the regulatory regulation of these prescriptions.
NETWORK ANALYSIS OF ETHEREUM LAYER 2
Authors: Liang Li , Qi Feikai , Gong Shicai
Published: February 2025

The cryptocurrency market has experienced remarkable growth and garnered widespread attention in recent years. Ethereum, as one of the most well-known cryptocurrencies, has faced criticism for its network congestion and high transaction fees. To address this issue, developers have proposed various scalability solutions. In this paper, we compare two different network solutions, Polygon and Arbitrum, to the Ethereum. Based on the research methodology of complex networks, this study encompasses various stages ranging from data collection and processing to the modeling and analysis of transaction networks. Our findings reveal that Arbitrum shows an advantage over Polygon when comparing the networks at the same transaction volume. With sufficient development, Rollups has the potential to become the preferred scaling solution for Ethereum. Additionally, our analysis illustrates that all transaction networks exhibit a small-world phenomenon when they reach a significant size.
DRAG REDUCTION OF A FINITE CIRCULAR CYLINDER WITH A BOXFISH-LIKE EXTENDED SURFACE
Authors: Bhuiyan Shorob Alam , Hossain Ikram , Hossain Redwan Hossain , Abir Md. Sakib Ibn Mobarak , Ahmed Dewan Hasan
Published: February 2025

In numerous aerodynamic applications, the greater drag coefficient of the bluff body in transitional flow, i.e., at subcritical Reynolds numbers, is one of the most significant problems.
Current research focuses on the drag reduction of a circular cylinder by utilizing a passive technique, both numerically and experimentally, for the subcritical Reynolds number with a range of 8.85×104 to 1.98×105. Initially, the frontal shape of the Boxfish was considered an extended surface and had a detrimental effect on drag reduction. Later, a modified design of the frontal part of the Boxfish is considered as an extended surface, and studies are carried out for three stem lengths (distance between the extended surface and cylinder) with a wide range of angles of attack. At an attack angle of 0°, a stem length of 80 mm reduces drag by 71% compared to a cylinder with no stem. Where 33% of the results integrating angle of attack were reduced at 5° angle of attack and 70 mm stem length, Current research suggests that a stem length of 80 mm reduces drag across a broad Reynolds number range. Numerical and experimental data indicate that boundary layer detachment and reattachment, as well as wake generation, decrease drag. Hence, offering a proposed design for future vehicles that generates less drag, thereby reducing environmental pollution.
AREA SWEPT BY THE RADIUS OF CURVATURE OF A FUNCTION AND APPLICATIONS TO MECHANICS
Authors: Pakdemirli Mehmet
Published: February 2025

A new integral quantity is defined in this work. For a given function in a definite interval, a special integral is defined to calculate the area swept by the radius of curvature of the function. The basic definition, theorems and examples are given first. Using variational calculus, the function corresponding to the minimum area swept by its radius of curvature is given in the form of an ordinary differential equation. The differential equation is solved and plots of the functions are given. An approximate solution is also discussed within the context and contrasted with the numerical solution. Finally, two applications from mechanics, namely the deflection of beams and the dynamics of motion in a curved path are treated.
COMPARISON OF MODIFIED RICE MILL AND JAPANESE MADE POLISHING MACHINE FOR SAPONIN REMOVAL OF QUINOA
Authors: Lham Pem , Norbu Kinga , Phuntsho Ugyen
Published: February 2025

With the introduction of quinoa in Bhutan as a priority crop in 2015, its production is seen increasing every year and so is its demand owing to its nutritional value. Quinoa is a great source of protein and has digestive health benefits including many other health benefits. However quinoa contains some anti-nutritional compound known as saponin which has a bitter and soapy taste and it can also be highly toxic if ingested in large quantities. Therefore the saponin content in quinoa needs to be removed before consumption. Currently there are only few numbers of quinoa polishing machines in Bhutan imported from Japan which is very expensive. Most of the Bhutanese farmers own a rice mill which actually is not designed for polishing quinoa, however a sieve which is the same size as that of quinoa polishing machine was designed and fabricated and used in rice mill for polishing quinoa and results were compared. A comparative evaluation of the machine was conducted and the result indicated high correlation with that of Japanese quinoa machine in polishing efficiency with higher machine capacity.
KINEMATICAL GENERALIZATIONS OF THE BRACHISTOCHRONE PROBLEM
Authors: Pakdemirli Mehmet
Published: February 2025

The brachistochrone problem is generalized for arbitrary velocity functions. The motion rather than the causes of the motion are considered with a kinematical analysis. In the most general form, the velocity is an arbitrary function of the independent and dependent variables as well as the slopes. Special cases of single variable velocity functions are then treated. For each case, some specific functions are considered as examples. The minimal paths are calculated using the principles of variational calculus. Curves are drawn which connects a given initial point to a final point. In some of the cases, the parametric solutions are given in the form of integrals and the constants appearing in the parametric solutions require a shooting like technique to allow the curves to reach their final destination points. The curves may be used in motion of land, marine and aerial vehicles if time is the most important factor in navigation.
El sentido del trabajo en disputa Estatuto del trabajo y la remuneración en el trabajo de plataformas
Authors: Quiñones Montoro Mariela , Cosse Reyes Leonardo
Published: February 2025

El artículo se propone discutir sobre el estatuto del trabajo y la remuneración en el trabajo de plataformas, y a partir de allí observar cómo se construyen las definiciones de situación en torno a esta cuestión por parte de los actores del mundo del trabajo (Estado, empresarios y trabajadores), siendo que estas se encuentran en terrenos en los que resulta difícil establecer acuerdos sobre qué es el trabajo en este nuevo contexto y cómo pueden las instituciones del trabajo comprehender y adaptarse para dar un marco de inteligibilidad a lo que allí ocurre. La discusión sobre la regulación del trabajo de plataformas que se procesa en Uruguay actualmente ofrece la ocasión de observar las tramas de significado en torno al estatuto del trabajo y la remuneración en la economía digital, y los desafíos que plantea para el movimiento sindical.
Las haciendas porfiristas en la configuración territorial de Comitán, Chiapas, México
Authors: García Gómez Karina , Azevedo Salomao Eugenia María
Published: February 2025

Una de las etapas históricas con más cambios urbano-arquitectónicos, político-económicos y sociales en México fue la época del porfirismo, en la que a través del impulso de las haciendas representó una de las estrategias esenciales para consolidar el país como una nación en progreso. Chiapas, uno de los estados al sur de la República mexicana, específicamente la región de Comitán, fungió como un área importante a nivel estatal en el desarrollo de sus espacios productivos, por lo que el objetivo de este artículo es dar a conocer las permanencias de estas haciendas en la estructura territorial de Comitán, la trascendencia de esta época y su impacto en la época actual. La metodología usada fue cualitativa basada en la interpretación documental, lectura de fotografías y cartografía histórica. Como resultado se presenta una reconstrucción histórica de la transformación territorial de Comitán a través del tiempo, valorando un patrimonio que ha sido olvidado.
Ciudad y urbanismo neoliberal, planes locales y transnacionales en la transformación de San José, Costa Rica
Authors: Jiménez Corrales Andrés
Published: February 2025

La neoliberalización urbana en América Latina ha provocado un proceso de intervención en el ambiente construido, y una trasformación en las estructuras institucionales y normativas de los gobiernos de las ciudades. En este trabajo se analizan las interrelaciones en la producción de urbanismo neoliberal entre actores locales y transnacionales. Se seleccionó como estudio de caso a la ciudad de San José, capital de Costa Rica; así como a los siguientes actores: el gobierno local de San José y el Banco Interamericano de Desarrollo (BID). Para esto se utilizó una metodología basada en técnicas de análisis documental a profundidad, indagando en documentos institucionales del gobierno local de San José, así como del BID. Las acciones ejecutadas fueron interpretadas como un urbanismo neoliberal imbricado, el cual se caracteriza por buscar un desarrollo urbano modernizador, ser selectivo espacialmente, y temático en sus proyectos.
Territorios hidrosociales y megaproyectos turísticos. La experiencia de Yucatán, México
Authors: Ríos Cabello Mariana , Paredes Guerrero Blanca Esther
Published: February 2025

El presente artículo se centra en la conceptualización de los territorios hidrosociales, en torno a la inserción de un megaproyecto turístico en Yucatán, México. Para su análisis se utilizó una estrategia metodológica cualitativa aplicada a un caso de estudio que abarca tres poblados de la península: Yalcobá, X’tut y Sisbichén, afectados actualmente por la construcción del megaproyecto turístico “Xibalbá”. El objetivo es identificar las racionalidades que conciben, definen y problematizan el territorio hídrico, desde las lógicas del estado-empresario, y revelar su inserción al territorio a través de mecanismos específicos. Concluye que el megaproyecto Xibalbá es un mecanismo de poder, caracterizado por lógicas que conciben el agua como recurso económico desde la industria cultural, que inserta racionalidades políticas a través de particularidades físicas, sociales, simbólicas y culturales del sitio acompañado por los siguientes mecanismos: La legislación, el discurso, las políticas públicas y la tecnología.
Patrimonialización del paisaje: proceso, discursos y conceptos
Authors: Laportilla Geidy , Urquijo Pedro Sergio , Rodríguez Andrea Berenice , Priego Ángel Guadalupe
Published: February 2025

La conservación del patrimonio en esfuerzos de instituciones y gobiernos ha tendido a la proyección territorial, favorecido un incremento de la valoración del paisaje, incluyendo la interacción entre sus componentes.  Sin embargo, el discurso patrimonial paisajístico prepondera a los paisajes patrimoniales como producto, por encima del proceso de patrimonialización que subyace en todo territorio previo a cualquier intervención; propiciando disonancias entre objetivos conservacionistas y efectos reales de la patrimonialización, así como conflictos entre estrategias institucionales e intereses locales. En este artículo se exploran las limitaciones del concepto de patrimonialización. A través de una revisión bibliográfica se analiza su alcance en relación con el paisaje y los distanciamientos entre los objetivos de protección ambiental en el marco institucional, así como las valoraciones, necesidades y prácticas locales de uso y consumo de los recursos naturales, que derivan de la apropiación local del paisaje.
Irracionalidade acadêmica: a universidade e as tiranias do tempo, da métrica e da competitividade
Authors: Melgaço Lucas
Published: February 2025

O artigo aborda as irracionalidades do atual modelo de gestão das universidades. Ele destaca como a busca por mais organização, eficiência e produtividade, muitas vezes baseada em princípios de racionalização, resulta em irracionalidades: individualismo, desumanização, desonestidade, superficialidade, perda de qualidade e aumento do estresse acadêmico. A partir de um diálogo com a literatura sobre a crise da universidade e de reflexões sobre as experiências do autor enquanto acadêmico em países distintos, o artigo explora três tiranias que dominam a academia contemporânea: tempo, métrica e competitividade, e questiona como essas pressões distorcem a essência contestadora, colaborativa e reflexiva da universidade. Por fim, propõe uma análise de contrarracionalidades acadêmicas como formas de resistência que surgem em resposta a esse modelo hegemônico, sugerindo alternativas que questionem o caráter estrutural do problema e estimulem o pensamento crítico.
Strategi Pembelajaran Pendidikan Agama Islam pada Anak Berkebutuhan Khusus Attention Deficit Hyperactivity Disorder (ADHD) di SLB Negeri Seduri Mojokerto
Authors: Muhajirin Ilham , Romli Muhammad
Published: February 2025

Penelitian ini bertujuan untuk mengetahui strategi pembelajaran Pendidikan Agama Islam pada anak berkebutuhan khusus Attention Deficit Hyperactivity Disorder (ADHD) di SLB Negeri Seduri Mojokerto; serta dampak perilaku peserta didik ADHD dari proses strategi pembelajaran Pendidikan Agama Islam di SLB Negeri Seduri Mojokerto. Jenis penelitian ini adalah deskriptif kualitatif. Teknik Pengumpulan data dilakukan melalui observasi, wawacara, dan dokumentasi. Hasil penelitian menunjukkan, pertama, bahwa strategi guru Pendidikan Agama Islam dalam melaksanakan proses pemebelajaran di SLB Negeri Seduri Mojokerto melalui tahapan perencanaan, pelaksanaan, dan evaluasi. Dalam proses pelaksanaan pembelajaran Pendidikan Agama Islam kepada peserta didik ADHD dilakukan dengan menggunakan strategi power strategy, strategi pembiasan, dan strategi keteladanan yang digunakan dalam proses internalisasinya kepada peserta didik ADHD. Untuk jenis pembelajaran Pendidikan Agama Islam yang diterapkan ialah membaca Al-Qur’an dan menghafal surah-surah pendek; senyum, sapa dan salam; salat zuhur berjamaah; pembelajaran audio visual; pondok Ramadan; dan (6) istigasah Jumat legi. Kedua, dampak perilaku peserta didik dari proses pelaksanaan pembelajaran Pendidikan Agama Islam terlihat pada kebiasaan sehari-hari, seperti gotong royong, menghormati guru, dan rasa toleransi.
This research aims to determine the learning strategies of Islamic Education for children with Attention Deficit Hyperactivity Disorder (ADHD) at Seduri Public Special School (SLB Negeri Seduri) Mojokerto, and to assess the impact of ADHD students’ behavior from the process of Islamic Education learning strategies at SLB Seduri Mojokerto. This study is a qualitative descriptive nature. Data collection techniques were carried out through observation, interviews, and documentation. The results of the research indicate, firstly, that the Islamic Education teachers’ strategies in implementing the Islamic Education learning process at SLB Seduri Mojokerto go through planning, implementation, and evaluation stages. In the implementation process of Islamic Education learning to ADHD students, strategies such as power strategy, habituation strategy, and exemplary strategy are used and internalized to ADHD students. The types of Islamic Education learning applied are reading the Qur’an and memorizing short chapters; smiles, greetings, and salutations; congregational zuhr prayer; audiovisual learning; Ramadan boarding; and Legi Friday istigasah. Secondly, the impact of students’ behavior from the implementation process of Islamic Education learning is evident in daily habits such as mutual cooperation, respecting teachers, and tolerance.
Persepsi Guru dan Siswa terhadap Manajemen Akreditasi di Sekolah Menengah Atas
Authors: Salsabilla Imelia Sahda , Niswah Sa'adatun , Jaya Arim Irsyadullah Albin
Published: February 2025

Penelitian ini bertujuan untuk menyelidiki bagaimana persepsi guru dan siswa terhadap proses akreditasi di sekolah menengah atas mempengaruhi metode pengajaran, interaksi, dan pengalaman belajar mereka. Studi menggunakan pendekatan kualitatif dengan studi kasus di SMAN 1 Kendal, melibatkan enam responden dari berbagai latar belakang pendidikan. Data dikumpulkan melalui wawancara mendalam, observasi, dokumentasi, dan survei untuk memperoleh pemahaman yang komprehensif tentang dampak akreditasi. Hasil penelitian menunjukkan bahwa: persepsi positif terhadap akreditasi mendorong kerjasama antar guru dalam pengembangan profesional dan inovasi dalam pengajaran; persepsi negatif dapat menyebabkan stres dan mengurangi motivasi siswa; komunikasi terbuka dari manajemen sekolah dalam persiapan akreditasi juga berperan penting dalam meningkatkan keterlibatan guru dan siswa. Temuan ini memberikan wawasan penting bagi pengembangan kebijakan pendidikan untuk memastikan bahwa proses akreditasi tidak hanya memenuhi standar, tetapi juga mendukung pengalaman belajar yang bermakna bagi semua stakeholder di sekolah menengah atas. Studi ini menegaskan bahwa upaya untuk meningkatkan pemahaman dan penerimaan terhadap proses akreditasi dapat membawa manfaat yang signifikan dalam meningkatkan kualitas pendidikan. Implementasi praktik-praktik komunikasi yang efektif dan transparansi dari manajemen sekolah dapat menjadi kunci dalam menciptakan lingkungan yang mendukung dan memotivasi baik guru maupun siswa.
This study aims to investigate how teachers’ and students’ perceptions of the accreditation process in senior high schools affect their teaching methods, interactions, and learning experiences. The study used a qualitative approach with a case study at SMAN 1 Kendal, involving six respondents from various educational backgrounds. Data were collected through in-depth interviews, observations, documentation, and surveys to gain a comprehensive understanding of the impact of accreditation. The results showed that: positive perceptions of accreditation encourage cooperation among teachers in professional development and innovation in teaching; negative perceptions can cause stress and reduce student motivation; open communication from school management in preparation for accreditation also plays an important role in increasing teacher and student engagement. These findings provide important insights for education policy development to ensure that the accreditation process not only meets standards, but also supports meaningful learning experiences for all stakeholders in senior high schools. This study confirms that efforts to improve understanding and acceptance of the accreditation process can bring significant benefits in improving education quality. The implementation of effective communication practices and transparency from school management can be key in creating a supportive and motivating environment for both teachers and students.
Tree Planting before Merriage in Village Regulation No. 2 of 2009 in Bone-Bone Village, Enrekang Regency According to Maslahah
Authors: Khairiah Nahdiatul , Salam Abdul , Jumadil Jumadil , Kappaja Ismail , BN Andi Muh. Taqiyuddin
Published: February 2025

This research was conducted to know (1) the implementation of regulation no. 2 of 2009 Article 3 Bone-Bone Village and (2) the perspective of benefits for the implementation of Bone-Bone Village regulations No. 2 of 2009 Article 5. This research is field research using qualitative methods. The approach used in this study is an empirical juridical approach, with data collection techniques through observation, interviews, and document review. primary and secondary primary data obtained by conducting interviews with village government, religious leaders, and communities involved secondary data from documents related to data analysis techniques in this study starting from the data collected and then analyzed, then classifying the data that has been collected then the data is concluded.The results of this study indicate that (1) Implementation of Regulation No. 2 of 2009 Article 5 Bone-Bone Village, there are two, namely the first introduction to Regulation No. 2 of 2009 Article 5 which introduces the regulation using socialization. Then the second is the stage of implementing regulation No.2 of 2009 Article 5, namely registration, then planting trees and reporting; (2) Rules for planting trees No. 2 of 2009 Article 5 This regulation aims for the benefit and welfare of the community. From the perspective of this benefit, it is maslahat mursalah. Maslahat mursalah is something that brings benefits (profits) and keeps harm (damage) away.