bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-Ebola Sequelae Among Child Ebola Survivors in Sierra Leone
Authors: Amuzu Claudette , James Peter Bai , Bah Abdulai Jawo , Bayoh Alex Vandy Saffa , Singer Shepherd Roee
Published: August 2021

Introduction

: There is limited data regarding the long-term health effects of child survivors of the 2013–2016 West African Ebola virus disease (EVD) outbreak. Here, we assess post-Ebola complications among EVD child survivors by comparing the self-reported symptoms between EVD child survivors and their close household contacts over one year after the end of the outbreak.
Methods

Child EVD survivors(n = 159) and their close contacts(n = 303) were enrolled in Western and Eastern Sierra Leone. Demographic and self-reported symptoms data were collected using an interviewer-administered questionnaire. We compared a list of self-reported symptoms between EVD child survivors and their close household contacts using backward stepwise logistic regression.
Results

Child EVD survivors were more likely to be orphans compared to their controls. Musculoskeletal, ocular, auditory and neurological symptoms were more prevalent among Ebola survivors than their close contacts (p < .001). Joint pain and headache were the most common self-reported symptoms, and child survivors and their contacts. Joint pain (AOR = 2.633; 95% CI1.313-5.278, p = 0.006), eye pain (AOR = 4.559,95%CI: 2.156–9.639, p < 0.001) hearing loss (AOR = 3.849, 95%CI: 1.151–12.871, p = 0.029), memory impairment (AOR = 7.763,.95%CI: 1.339–45.007 p = 0.022), mood changes (AOR = 5.070, 95%CI: 2.350-10.939, p < 0.001) were more common among survivors than their contacts.
Conclusion

Our data suggest that child EVD survivors have higher odds than their close contacts to suffer from post-Ebola musculoskeletal, ophthalmic, auditory and neurological impairment more than a year after the end of the EVD outbreak. Routine screening, treatment and monitoring of these symptoms is required to prevent long-term disability among child Ebola survivors.
In vitro anti-cancer effect of Crataegus oxyacantha berry extract on hormone receptor positive and triple negative breast cancers via regulation of canonical Wnt signalling pathway
Authors: K Salini , Sivasithamparam Niranjali Devaraj
Published: August 2021

Breast cancer treatment strategy depends mainly on the receptor status. Our aim was to identify a herbal preparation, effective against breast cancer, irrespective of hormone sensitivity, and to understand its molecular mechanism. The rich antioxidant composition of Hawthorn ( Crataegus oxyacantha ) makes it a promising anti-cancer drug candidate. Polyphenol-rich methanolic extract of C. oxyacantha berry (M.Co) was found to be cytotoxic on hormone receptor positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines, at a dose (75 mg/ml) safe on normal cells. It could effectively inhibit tumor cell proliferation and arrest cell cycle at G1/S transition in both cell lines. Molecular targets were selected from different levels of canonical Wnt signalling pathway (such as autocrine and antagonistic ligands, receptor, effector, cytoplasmic components, downstream targets and pathway antagonist), since they are frequently found dysregulated in all breast cancers and their aberrant activation is associated with cancer stem cell expansion. M.Co could significantly downregulate the expression of Wnt pathway agonists and upregulate that of Wnt antagonists at transcriptional and translational levels, in both cell lines. To conclude, C. oxyacantha berry extract is effective against breast cancer irrespective of its hormone dependency and cancer growth inhibition at stem cell level can be expected.
Youtube English videos as a source of information on shoulder exercise after breast cancer surgery
Authors: Guloglu Selen , Ozdemir Yunus , Basim Pelin , Tolu Sena
Published: August 2021

Purpose

To examine the content, quality and reliability of YouTube videos on exercises that can be performed after breast cancer surgery.

Methods

Videos selected from YouTube using the search terms “shoulder exercise and breast cancer surgery”, “arm exercise and breast cancer surgery”, and “physiotherapy/physical therapy and breast cancer surgery” were categorized as useful or misleading by a doctor and a physiotherapist. The videos were analyzed using the five-point DISCERN scale for reliability, the five-point Global Quality Scale (GQS) for quality, and a 10-item scale for comprehensiveness.

Results

Of the 180 videos initially analyzed, 82 were included in the study, and 42 (51.2%) were classified as having misleading information and 40 (48.8%) as having useful information. The reliability, content and quality scores of the videos containing useful information were higher (p<0.001). Most of the videos in the useful information group (80%) were uploaded by universities/professional organizations/physicians/physiotherapists, while the majority of those in the misleading information group (47.6%) were uploaded by websites providing independent healthcare information. The total and daily views of the videos were higher in the useful information group than in the misleading information group (p<0.001 and p=0.004, respectively). When the video parameters were evaluated between the two groups, no significant difference was found in the number of likes and comments and video length.

Conclusion

YouTube can be an important instrument to protect patients from musculoskeletal system complications after breast cancer surgery and improve existing complications. Universities, physicians, and physiotherapists should be encouraged to prepare more videos containing full and accurate information on this subject.
Essential Stressing State Features of Laterally Loaded Masonry Wall Panels Revealed from Experimental Displacements
Authors: Liu Bai , Li Rui , Zhang Yu , Zhou Guangchun
Published: August 2021

This study reveals the essential and general working features of laterally loaded masonry (LLM) wall panels from their experimental displacements by applying structural stressing state theory. Firstly, the generalized work of force is proposed to express the stressing state mode and its characteristic parameter. Then, the Mann-Kendall criterion is applied to detect the mutation point in the curve of the characteristic parameter with the load increase. Correspondingly, it is verified that the evolution of the stressing state mode also embodies the mutation feature. The stressing state mutation feature is inherent and common as the embodiment of the natural law from quantitative change to qualitative change of a system. The stressing state mutation feature reveals the starting point of structural failure process, which could update the existing definition of structural failure load. Further, the elastoplastic branch (EPB) point is revealed referring to the updated failure load, which might be directly taken as the design load with the rational margin of safety. In a sense, this paper presents a new way to address the classic issue of structural load-bearing capacity uncertainty and to update the existing design codes of LLM wall panels.
Swedish healthcare for women subjected to Female Genital Mutilation/Cutting (FGM/C)
Authors: Akhavan Sharareh
Published: August 2021

Background: FGM/C can lead to a number of health complications, such as pain during intercourse or childbirth, psychological problems, and postpartum complications. This study seeks to describe and assess Swedish healthcare for women subjected to FGM/C.Methods: This aim encompasses three research foci: (1) to inventory Swedish regional healthcare guidelines and policies for care for women who have undergone FGM/C, (2) to map healthcare consumption among women who have undergone FGM/C, and (3) to map the type of care measures and treatment they have been offered in the Swedish healthcare system. A questionnaire was sent to healthcare regional managers and a database study was conducted.Results: The inventory of the healthcare regions' guidelines shows that five of 21 had no guidelines. The number of women who have been subjected to FGM/C and sought care has increased steadily between 2012 and 2018. Women who have been subjected to FGM/C seek care mostly in connection with pregnancy and childbirth.Conclusions: The type of care that should be offered to women who have been subjected to FGM/C vary depending on individual needs. Care may include surgical procedures in the form of defibulation, clitoral reconstruction, or removal of cysts, as well as psychosexual care. Existing treatment options in surgical care, together with psychosexual treatment, are the care measures that seem to be helpful for some women who have undergone FGM/C, but not for all. Communication and treatment are of great importance in order to be able to offer care to women who have undergone FGM/C.
Infections caused by the Delta variant (B.1.617.2) of SARS-CoV-2 are associated with increased viral loads compared to infections with the Alpha variant (B.1.1.7) or non-Variants of Concern.
Authors: von Wintersdorff Christian , Dingemans Jozef , Alphen Lieke van , Wolffs Petra , Veer Brian van der , Hoebe Christian , Savelkoul Paul
Published: August 2021

There has been a growing body of evidence that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant (B.1.617.2) shows enhanced transmissibility and increased viral loads compared to other variants. A recent study has even suggested that respiratory samples from people infected with the Delta variant can harbor up to 1000 times higher viral loads compared to samples with variants that are more closely related to the original Wuhan strain, although the sample size of this study was very limited. Here, we have compared the viral load in 16,185 samples that were obtained during which non-VOC, the Alpha (B.1.1.7) or Delta variant (B.1.617.2) were dominant as evidenced by genomic surveillance. We found that the Delta variant contained about 4-fold higher viral loads compared to the non-VOC or Alpha variants.
Sleep duration during COVID-19 lockdown: systematic review and meta-analysis
Authors: Stukalin Yelena , Lan Anat , Kronfeld-Schor Noga , Shmueli Erez , Einat Haim
Published: August 2021

In attempts to slow down the spread of COVID-19 pandemic, countries took different measures including lockdowns. Several studies reported the effects of lockdowns on sleep mostly suggesting an increase in sleep duration during lockdowns. This is an interesting outcome as life in the modern world were associated with insufficient sleep. The present study is a systematic review and meta-analysis of work regarding sleep duration during lockdowns. We searched PubMed using the terms “COVID-19”, “SARS-CoV-2”, “lockdown”, “stay at home”, “quarantine” and “sleep” and found 262 papers. After applying exclusion criteria, we identified 26 papers (with 35 discrete studies) for the meta-analysis. A fixed effect model was used with effect sizes estimated using Cohen’s d and heterogeneity of effect sizes tested using the Cochran’s Q test statistics. Most studies (31/35) report an increase in sleep duration during lockdown periods with a mean (± STD) of 31.5 ± 21.2 minutes. Effect sizes (Cohen’s d) ranged between 0.08 and 3.34, which are considered between very small and huge. Q statistics was 4859.3 (p < 0.0001) and with no indication for publication bias (Egger’s test, p = 0.45). Eight studies also reported measures of “sleep quality” with 6/8 reporting worsening of sleep quality with small to large effect sizes Cohen’s d range between 0.09 and 1.86). The study demonstrates increased sleep duration during lockdowns. Increased sleep duration is a positive change, but effects on well-being during lockdowns might be overshadowed by reduced sleep quality, increased stress, and lowered mood. It is interesting whether longer sleep duration habits may survive to post-COVID-19 days.
On issue of criminal liability for violations of intellectual property rights
Authors: Utkina M.S.
Published: August 2021

The issues of criminal liability for violations of intellectual property rights in Ukraine as well as examples of foreign countries (Federal Republic of Germany, French Republic, United States of America, Swiss Confederation) were analyzed. The author has identified major international instruments that set out basic international standards for the protection of intellectual property rights. It has been determined that Article 61, Section 5, of the Agreement on Trade-Related Aspects of Intellectual Property Rights, or the TRIPS Agreement, lays down provisions on criminal proceedings. The author analyzed the provisions of the current criminal legislation of Ukraine, according to which the occurrence of criminal liability is possible in case of violation of property rights of owners, without taking into account personal non-property rights. The article also states that, in accordance with the provisions of the articles of the Criminal Code of Ukraine, a peculiarity of domestic criminal legislation on infringement of intellectual property rights is that this type of liability can occur only if the owner of the rights of property damage in a large, large or especially large size. With regard to the Institute of Industrial Property, the Criminal Code of Ukraine provides for liability for the unlawful use of an invention, utility model, industrial design or variety of plants, if the material damage was done, as previously stated, in a significant, large or particularly large sizes. The author has determined that the urgency of the solution requires the issue of extending legal protection to new and emerging technologies. As with this, the nature of the violations and the process itself change. Against this background, there is a serious challenge to the intellectual property system. In turn, the process of protection and protection of intellectual property may be enhanced by having an adequate and effective system of state mechanism for preventing and ending offenses. It can also be achieved by simplifying the process of proving infringement in the field of intellectual property, and thus the procedure for bringing the perpetrator to justice.
Elemental composition of forensic characteristics of human trafficking
Authors: Kovalenko V.V.
Published: August 2021

The article is devoted to the study of the elemental composition of the forensic characteristics of human trafficking. It is noted that a quick, complete and comprehensive investigation of criminal offenses related to human trafficking is impossible without the use of modern advances in forensic science, in particular, without the use of forensic recommendations reflected in the methodіcs of investigation of this crime. The basic element of any particular methodics of investigating of crimes is considered to be a forensic characteristic. Its essence is that it is considered as a system that contains signs and data on the regular connections of traces, expressed by the appropriate degree of probability and established on the basis of generalization of materials of criminal proceedings, tested by investigative practice. Such data form the basis for the construction of systems of standard versions, which are used in solving specific investigative tasks and promoting further versions. Emphasis is placed on the fact that the task of methodological recommendations for the investigation of crimes is to develop standard systems (algorithms) of actions of the investigator, which contribute to the selection of optimal behavior during the investigation of a particular type of crime. Forensic methodic makes extensive use of criminal law, criminology, and criminal procedure data while developing recommendations. Its information sources are the scientific provisions of the theory of forensic science, data from other sciences, the results of generalization of investigative and judicial practice, the rules of relevant legislation and other regulations. Based on the study of the opinions of scientists, analysis of the results of generalization of the practice of pre-trial investigation and court proceedings on the facts of human trafficking, the elemental composition of the forensic characteristics of the crime under Art. 149 of the Criminal Code of Ukraine is established, which includes the identity of the victim; typical ways of preparing, committing and concealing a crime; typical traces and circumstances of the crime; the identity of the offender.
Рroblem aspects of individual, ordinary proceedings and in-council consideration of the case in terms of civil procedural legislation of Ukraine
Authors: Polishchuk M.H.
Published: August 2021

In the order of the civil legal proceeding taken shipping from the civil, housings, domestic, labour relations landed,, and also from other legal relationships, exept for the cases when consideration of so goes the world is conducted after the rules of other court. Matters of obednuyut'sya in certain categories, that influences on the judicial specific of the legal proceeding. The article is devoted the problem aspects of separate, order realization and extra-mural consideration of business within the limits of civil judicial legislation of Ukraine. In the article the compressed description is given each of realizations, it is indicated on terms at which taken shipping in each of types of realizations, namely to separate, order, and zaochnomu. Each of the selected types of realization has inherent only this type of feature of their consideration in a court. Therefore description of realization in the civil rule-making pulls the special order (procedure) of consideration of separate categories of legal businesses; well-regulated the norms of civil judicial law order of realization in civil cases, that is determined by the system of взаємопов'язаних civil judicial laws and duties and civil judicial actions they will be realized that by subjects - court and participants of process; character determines and by the specific of material right or охоронюваного law of interest, that is subject to defence; judicial order of violation, consideration, decision of certain group of civil cases. From December, 15, 2017 changes inured in a Civilly-judicial code, and essentially a civil judicial law is expounded in a new release, here him substantially and it is radically changed. From this time courts apply new judicial norms. Thus, there is founding preliminary to analyse the next types of realizations. In accordance with a Civilly-judicial code by the tasks of civil is guard of rights and legal interests physical, legal entities, states by all-round just, timely consideration and dispatch of civil civil businesses in complete and by a current legislation. Legislation about the civil rule-making вс order of consideration of the civil cases incorporated after signs in three types of realizations lawsuit; separate; order.
Mediation procedure in Ukrainian realities
Authors: Kobzeva T.A. , Kulish I.O.
Published: August 2021

In the modern world, the mechanisms of self-regulation become especially important, when the subjects of public relations have the opportunity to independently establish rules of conduct and monitor their observance. The growth of activity and responsibility of participants in civil turnover allows the state to delegate part of its powers in certain areas to civil society institutions. Reconciliation of the parties is one such institution. Today in Ukraine, court proceedings and other jurisdictional mechanisms for reviewing and resolving disputes are the main ways to protect violated rights, freedoms and legitimate interests. However, there is no denying that in today's conditions of formation and dynamic development of civil society, they are often not effective enough. Participants in disputed legal relations are becoming increasingly interested in selfsettlement of disputes arising between them. One of the alternative methods of conflict resolution is mediation. Mediation, as an effective method of pre-trial settlement of disputes, is recognized by the European Community, which recommends its introduction as the main method of alternative dispute resolution at the pre-trial stage and during court proceedings. Mediation procedure, as an effective method of pre-trial settlement of disputes, is relevant for almost all types of legal relations, but unfortunately is not always used, due to the fact that for a long time there was no relevant legislation that could clearly and effectively to settle relations in the field of mediation. On July 15, 2020, the draft Law on Mediation was adopted in the first reading. will provide an opportunity to unload the judiciary and provide a mechanism for the implementation of protection of fundamental human and civil rights and freedoms in our country, as in a modern European state. The scientific work determines the correct use of the mediation procedure and its implementation to today's Ukrainian realities.
Phosphorus Bioavailability and Migration of Hydroxyapatite in Different Sizes as Phosphorus Fertilizer in Camellia Oleifera Seedlings
Authors: Lin Minghao , Liu Pengqi , Jun Li , Zhou Wenjun , Yuan Jun
Published: August 2021

Low mobility and solubility reduce the availability of traditional phosphorus (P) fertilizer in red acidic soil. Hydroxyapatite (HAP), especially nano-hydroxyapatite (n-HAP), may be more efficient than P fertilizer because of its nanoparticle characteristics. Camellia oleifera (C. oleifera) is an edible oil tree whose productivity is greatly affected by P fertilizer. During this study, we investigated the migration of different particle sizes of HAP (20 nm, 200 nm, and 80 μm) and their effects on the seedling growth of C. oleifera cultivar Huashuo (HS) cuttings. A column experiment showed that the efflux ratio was negatively correlated with particle size in red acidic soil. The leaching results revealed that the contents of total P and available P in the 20-nm treatment were significantly higher than those in the 200-nm and 80-μm treatments in the deep soil (10–15 cm or 15–20 cm), whereas the application of 20-nm n-HAP caused 13.43% wastage of available P. During the container experiments, 200-nm and 20-nm HAP significantly promoted the growth of the seedlings in terms of seedling height, stem diameter, and biomass. The available P contents in the rhizosphere and nonrhizosphere soils were negatively correlated with the HAP particle sizes. In conclusion, the migration of HAP is inversely correlated with particle size, and HAP improves the P bioavailability in red acidic soil. In summary, 200-nm HAP was the best P fertilizer for the seedlings of HS among the three particle sizes. This study offers preliminary results indicating that 200-nm HAP might be a better P fertilizer compared with other two HAP particle sizes for use in future C. oleifera orchards.
Proximate Compositions and Fatty Acid Profiles of Promising Almond (Prunus amygdalus L.) Genotypes Selected from Yesilyurt (Malatya) Region
Authors: GÜLSOY Ersin
Published: August 2021

This research was carried out to determine various proximate chemical properties and fatty acid profiles of ten promising almond genotypes selected from the Yeşilyurt district of Malatya province. The ratio of crude oil was minimum in YSY-14 (53.10%) and maximum in YSY-22 (66.42%) genotypes, however, the ratio of protein was minimum in YSY-54 (63.1%) and maximum in YSY-68 (26.79%) genotypes. In the study oleic acid, linoleic acid, palmitic acid, palmitoleic acid, and stearic acid, the content of the selected genotypes were ranged from 71.09% (YSY-15) to 79.49% (YSY-61), 11.04% (YSY-61) to 18.75% (YSY-59), 5.47% (YSY-68) to 6.65% (YSY-62), 0.56% (YSY-22) to 0.72% (YSY-14), 1.07% (YSY-50) to 1.64% (YSY-54), respectively. Besides, they had 86.85% - 91.39% unsaturated fatty acid content, 6.65% - 7.95% saturated fatty acid content, and 11.05-13.26% unsaturated fatty acid/saturated fatty acid ratio.
Emerging pollutants and antibiotics removed by conventional activated sludge followed by ultraviolet radiation in a municipal wastewater treatment plant in Mexico
Authors: Martínez-Orgániz Ángeles , Bravo José Elías Becerril , Llompart María , Dagnac Thierry , Pablo Lamas J. , Vázquez Lúa , Sampedro-Rosas Laura
Published: August 2021

Different groups of emerging pollutants (EPs) were identified (drugs, pesticides, hormones, illicit drugs, and fire retardant), and the removal of four antibiotics was determined (sulfamethoxazole 62.2–94.4%, ciprofloxacin 71–83.1%, norfloxacin 82–89%, and ofloxacin 78–97.9%) in a municipal wastewater treatment plant (WWTP) in Acapulco, Gro. Mexico. The compounds were extracted from influent and effluent samples by solid phase extraction (SPE). The identification of non-target EPs was performed by liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). The antibiotic quantification was performed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Most of the non-target compounds were detected only in the influent samples. Antibiotics levofloxacin and nalidixic acid, the anticonvulsants carbamazepine and oxycarbamazepine, the local anesthetic lidocaine, and the pesticide tridemorph were the main EPs not removed by the WWTP. In this study, it was shown that the Aguas Blancas WWTP does not manage to remove 100% of the various EPs identified in the effluent, although the elimination degree is high in most cases, despite being one of the model plants in Mexico.
Análise epidemiológica comparativa entre transplante hepático de doadores vivos e doadores mortos nos últimos 5 anos no Rio de Janeiro
Authors: Da Silva Gaspar Maria Carolina , Da Silveira Pacheco Ferraz Júlia , Do Espírito Santo e Santos Mariana , Vasconcellos Guide Thayssa , Monteiro Dantas Cristina Maria
Published: August 2021

O transplante de fígado é o tratamento de escolha para pacientes com insuficiência hepática, quando não há mais proposta terapêutica conservadora efetiva. Os objetivos do transplante são melhorar a qualidade de vida do paciente e prolongar sua sobrevida. Este órgão pode ser doado a partir de um cidadão vivo ou falecido. O propósito deste estudo é realizar uma análise comparativa, no Estado do Rio de Janeiro, entre cada procedimento, considerando dados como número total de cirurgias, custo médio, taxa de mortalidade e tempo médio de internação. Segundo os resultados, no Rio de Janeiro, 91,2% dos transplantes utilizaram órgão de doadores falecidos e 8,71% de vivos. Os custos foram de R$ 82.162,94 para procedimento intervivos e R$ 94.216,91 para falecidos. A média de internação foi de 13,9 dias para o procedimento entre vivos e 10,5 dias para doador morto. A taxa de mortalidade e óbitos foram 8,97% e 7, respectivamente, para doadores vivos e 10,77% e 88 para doadores mortos. Apesar da predominância de doadores falecidos, esse procedimento apresenta empecilhos como a resistência das famílias a doação e problemas organizacionais do órgão responsável. E, ainda, existe um temor por parte dos candidatos a doadores em vida com sua saúde e complicações cirúrgicas. Sendo assim, há necessidade de conscientizar a população sobre a importância de ser doador, esclarecer as famílias o real significado da morte encefálica e sanar possíveis dúvidas. Somente o estímulo a ambos os tipos de doação poderá reduzir as filas de espera e salvar vidas.
Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders
Authors: Rodriguez Eric A. , Yamamoto Bryan K.
Published: August 2021

Methamphetamine (Meth) abuse presents a global problem and commonly occurs with
stress and/or alcohol use disorders. Regardless, the biological causes and consequences of these comorbidities
are unclear. Whereas the mechanisms of Meth, stress, and alcohol abuse have been examined
individually and well-characterized, these processes overlap significantly and can impact the neural
and peripheral consequences of Meth. This review focuses on the deleterious cardio- and cerebrovascular
effects of Meth, stress, alcohol abuse, and their comorbid effects on the brain and periphery.
Points of emphasis are on the composition of the blood-brain barrier and their effects on the heart and
vasculature. The autonomic nervous system, inflammation, and oxidative stress are specifically highlighted
as common mediators of the toxic consequences to vascular and perivascular health. A significant
portion of the Meth abusing population also presents with stress and alcohol use disorders,
prompting a need to understand the mechanisms underlying their comorbidities. Little is known about
their possible convergent effects. Therefore, the purpose of this critical review is to identify shared
mechanisms of Meth, chronic stress, and alcohol abuse that contributes to the dysfunction of vascular
health and underscores the need for studies that directly address their interactions.
Anti-infective Potential of Manzamine Alkaloids - A Review
Authors: Ashok Penta , Faheem  , Kumar Banoth K. , Chander Subhash , Chandra Sekhar Kondapalli Venkata Gowri , Sankaranarayanan Murugesan
Published: August 2021

Background:

From time immemorial, natural products have been used for the treatment of
various diseases. Various natural products, their semisynthetic derivatives, and synthetic analogs
have been explored for their anti-infective properties. One such group of natural compounds that has
been widely explored is manzamine alkaloids. Manzamine alkaloids are complex natural compounds
consisting of a β-carboline nucleus attached to a pentacyclic ring system; they were first isolated
from a marine sponge during the 1980s.

Objective:

This review aims to provide a critical overview on the anti-infective potential of manzamine
alkaloids.

Method:

A comprehensive and exhaustive review of the literature on manzamine alkaloids, and
their isolation, anti-infective properties, and mechanism of action, is presented.

Results:

Various manzamine alkaloids have been isolated and have been found to exhibit potent antiinfective
activities like antibacterial, antimalarial, antiviral, antifungal, antileishmanial, among others.
These manzamine alkaloids exhibit their anti-infective activity by inhibiting targets like GSK-3β,
MtSK.

Conclusion:

This present review along with structure-activity relationship study of manzamine alkaloids
for their anti-infective activity will be useful for further development of semisynthetic manzamine
analogs as potent anti-infective agents with better therapeutic potential and reduced toxicity.
Social Adapter Model: Development of Coastal Resources Potential Through Empowerment of Coastal Communities in Watu Pecak Beach Lumajang District
Authors: Kurniawati Affroh , Yuliati Yayuk , Susilo Edi
Published: August 2021

Coastal areas and their natural resources have an important meaning for the economic development of the Indonesian people. This is reflected in the East Java region, which is one of the provinces rich in natural resources, both in the form of minerals and fishery products. For example in the area of Watu Coast Pecak there is potential for natural resources such as Pasir Pantai which has good quality sand for house building and this is an attraction for itself to develop. The purpose of this study was to identify the implementation of the management of Watu Pecak Beach in developing coastal resource potential at Watu Pecak Beach, identifying the role of stakeholders in the management of Watu Pecak Beach, analyzing the activities of the WatuPecak Coast community in utilizing coastal resources available at Watu Pecak Beach, and designed a Social Adapter Model for the development of coastal resource potential in Watu Pecak Beach. The data analysis used in this study used a qualitative descriptive method. The results showed that the implementation of the management of Watu Pecak Beach was still not optimal. The role of stakeholders in implementing Watu Pecak Beach is still not fully active because it is still constrained by administrative permits. The activities of the coastal communities of Watu Pantai Pecak have a variety of activities. The design of this ring circumference social adapter model is used as a frame to strengthen the institutions of coastal communities in Watu Pecak Beach.
Female Sexual Function Index in Perimenopause Women After Loving Yoga Intervention in Yogyakarta
Authors:   a Program Studi Kesehatan Masyarakat Program Doktoral, Sekolah Pascasarjana, Universitas Sebelas Maret
Published: August 2021

During perimenopause, females experience decrease in sexual function. Loving yoga has a focus of movement on the pelvic muscles is a complementary therapy to overcome such complaints. The purpose of this study was to analyze the large influence of the sexual function index of perimenopause women simultaneously and partially after doing loving yoga. Quantitative research with the cross-sectional design was conducted from April to June 2020 in Yogyakarta. Purposive sampling in women aged 40-50 years, sexually active, and having a sexual dysfunction. The data was collected through a Female Sexual Function Index (FSFI) questionnaire and then tabulated and scoring. Data analysis in univariate and multivariate using linear regression analysis multiple partial t-tests and simultaneous F test. The results stated that there is a simultaneous and partial influence on sexual function (Sig value. < 0.05), with great influence on sexual interest (16,541%), sexual arousal (15,289%), lubrication (18,233%), orgasm (16,036%), sexual satisfaction (16,330%), and dyspareunia (17,586%). In conclusion, loving yoga can improve the sexual function of perimenopause women. Therefore, it is recommended that this exercise can be done regularly to get the optimal effect.
Pengaruh Pemberian Air Rebusan Biji Alpukat (Persea americana Mill) Terhadap Pertumbuhan Jamur Candida albicans Secara In Vitro
Authors:   Program Studi S1 Kebidanan, Fakultas Kedokteran, Universitas Brawijaya, Nabilla Tahta Avwina Amir Nayla , Winarsih Sri ,   Fakultas Kedokteran, Universitas Brawijaya, Rahardjo Bambang ,   RSSA Malang
Published: August 2021

The most common cause of patalogis leucorrhoea is infection, one of which is Vulvovaginal Candidiasis (VVC) caused by fungus, while 80% -90% is caused by Candida albicans. Approximately 90% of young women in Indonesia have the potential to experience vaginal discharge because Indonesia is a tropical climate. Alternative treatment for antifungal drugs is needed through the exploration of natural material sources that have the potential as antifungals to deal with this infection safely and easily. The design used in this study was experimental research by in vitro using the dilution method of the tube. Treatment concentrations are 45%; 40%; 35%; 30%; 25%; 20%, 15% and 0% with Candida albicans 104 CFU / ml samples from the microbiology laboratory of the medical faculty Brawijaya University and repeated 3 times. The result showed that at all concentrations, growth was still obtained in agar media so that it could be denied that the boiled water of avocado seeds had no effect on the growth of Candida albicans fungal colonies in vitro because there were still fungal colonies on the plates.
Web-Based Guidance Through Assisted Reproductive Technology (myFertiCare): Patient-Centered App Development and Qualitative Evaluation
Authors: Sparidaens Ellen Marie , Hermens Rosella P M , Braat Didi D M , Nelen Willianne L D M , Fleischer Kathrin
Published: August 2021

Background

Providing patient-centered fertility care is known to improve quality of life and can reduce anxiety and depression. In a previous study, we established the need for a web-based app providing personalized information and interactive functionalities among couples undergoing intracytoplasmic sperm injection with surgically retrieved sperm.

Objective

This study aimed to design, develop, and qualitatively evaluate a multifaceted web-based app for infertile couples undergoing intracytoplasmic sperm injection with surgically retrieved sperm during their treatment trajectory.

Methods

The web-based app was developed in three phases: (1) we established a patient-centered functional design, (2) developed the app in collaboration with medical and technical professionals, and (3) qualitatively evaluated the app among couples using a think-aloud method.

Results

The basis of the app is the couple’s visualized treatment trajectory. The app provides personalized and interactive functionalities; for example, customized information and communication options. During qualitative evaluation, myFertiCare was highly appreciated and received a median score of 8 out of 10. The main improvements made upon conclusion of the think-aloud sessions were related to faster login and easier app navigation.

Conclusions

A patient-centered web-based app aimed at guiding couples through their fertility treatment course was systematically designed, developed, and positively evaluated by patients and medical and technical professionals.
Acceptability, Engagement, and Effects of a Mobile Digital Intervention to Support Mental Health for Young Adults Transitioning to College: Pilot Randomized Controlled Trial
Authors: Suffoletto Brian , Goldstein Tina , Gotkiewicz Dawn , Gotkiewicz Emily , George Brandie , Brent David
Published: August 2021

Background

The transition from high school to college can exacerbate mental health problems in young adults yet barriers prevent seamless mental health care. Existing digital support tools show promise but are not yet designed to optimize engagement or implementation.

Objective

The goal of the research was to test acceptability and effects of an automated digital Mobile Support Tool for Mental Health (MoST-MH) for young adults transitioning to college.

Methods

Youths aged 18 years and older with a current mental health diagnosis preparing to transition to college (n=52; 85% female [45/52], 91% White [48/52]) were recruited from a primary care (n=31) and a mental health clinic (n=21). Participants were randomized 2:1 to either receive MoST-MH (n=34) or enhanced Usual Care (eUC; n=18). MoST-MH included periodic text message and web-based check-ins of emotional health, stressors, negative impacts, and self-efficacy that informed tailored self-care support messages. Both eUC and MoST-MH participants received links to a library of psychoeducational videos and were asked to complete web-based versions of the Mental Health Self-Efficacy Scale (MHSES), College Counseling Center Assessment of Psychological Symptoms (CCAPS), and Client Service Receipt Inventory for Mental Health (C-SRI) monthly for 3 months and the Post-Study System Usability Scale (PSSUQ) at 3-months.

Results

MoST-MH participants were sent a median of 5 (range 3 to 10) text message check-in prompts over the 3-month study period and 100% were completed; participants were sent a median of 2 (range 1 to 8) web-based check-in prompts among which 78% (43/55) were completed. PSSUQ scores indicate high usability (mean score 2.0). Results from the completer analysis demonstrated reductions in mental health symptoms over time and significant between-group effects of MoST-MH compared to eUC on depressive symptom severity (d=0.36, 95% CI 0.08 to 0.64). No significant differences in mental health self-efficacy or mental health health care use were observed.

Conclusions

In this pilot trial, we found preliminary evidence that MoST-MH was engaged with at high rates and found to be highly usable and reduced depression symptoms relative to eUC among youth with mental health disorders transitioning to college. Findings were measured during the COVID-19 pandemic, and the study was not powered to detect differences in outcomes between groups; therefore, further testing is needed.

Trial Registration

ClinicalTrials.gov NCT04560075; https://clinicaltrials.gov/ct2/show/NCT04560075
Ecological Momentary Assessment of Depression in People With Advanced Dementia: Longitudinal Pilot Study (Preprint)
Authors: Niculescu Iulia , Quirt Hannah , Arora Twinkle , Borsook Terry , Green Robin , Ford Brett , Iaboni Andrea
Published: August 2021

BACKGROUND

Barriers to assessing depression in advanced dementia include the presence of informant and patient recall biases. Ecological momentary assessment provides an improved approach for mood assessment by collecting observations in intervals throughout the day, decreasing recall bias, and increasing ecological validity.

OBJECTIVE

This study aims to evaluate the feasibility, reliability, and validity of the modified 4-item Cornell Scale for Depression in Dementia for Momentary Assessment (mCSDD4-MA) tool to assess depression in patients with advanced dementia.

METHODS

A intensive longitudinal pilot study design was used. A total of 12 participants with advanced dementia were enrolled from an inpatient psychogeriatric unit. Participants were assessed using clinical depression assessments at admission and discharge. Research staff recorded observations four times a day for 6 weeks on phones with access to the mCSDD4-MA tool. Descriptive data related to feasibility were reported (ie, completion rates). Statistical models were used to examine the interrater reliability and construct and predictive validity of the data.

RESULTS

Overall, 1923 observations were completed, representing 55.06% (1923/3496) of all rating opportunities with 2 raters and 66.01% (1923/2913) with at least one rater. Moderate interrater reliability was demonstrated for all items, except for lack of interest. Moderate correlations were observed between observers and patient-reported outcomes, where observers reported fewer symptoms relative to participants’ self-reports. Several items were associated with and able to predict depression.

CONCLUSIONS

The mCSDD4-MA tool was feasible to use, and most items in the tool showed moderate reliability and validity for assessing depression in dementia. Repeated and real-time depression assessment in advanced dementia holds promise for the identification of clinical depression and depressive symptoms.
PHYTOCHEMICAL STUDIES OF ENDOLICHENIC FUNGI ISOLATED FROM HYPOTRACHYNA INFIRMA (KUROK.) HALE
Authors: R. GOKILAVANI , BANU H. REHANA
Published: August 2021

Objective: The aim of this study is to investigate of phytopharmaceutical importance of endolichenic fungi isolated from Hypotrachyna infirma (Kurok.) Hale.
Methods: The lichen species were collected from Sholaiyar hills, Coimbatore and identified as Hypotrachyna infirma (Kurok.)Hale. From this lichen, 29 endolichenic fungi were isolated and 13 endolichenic fungi were identified. From the identified endolichenic fungi, 26 extracts were prepared by successive solvent extraction methods using Ethyl acetate and chloroform.
Results: The phytochemical study revealed the presence of important constituents like Alkaloids, Tannins, Carbohydrates, Phenols, Protein, Terpenoids, Steroids, Glycosides Flavonoids and Saponins. From the 13 endolichenic fungi, only 5 endolichenic fungi (Nigrospora oryzae (Berkand Broome)Petch, Geotrichum candidum Link, Scytalidium lignicola pesante, Aspergillus oryzae(Ahlb.) cohn, Aspergillus niger Gr.) have more constitutents. These 5 endolichenic fungi have good results in Quantitative analysis also.
Conclusion: Compared to ethyl acetate extracts Chloroform extracts showed very less concentration of the phytochemicals. From this study we conclutated Nigrospora oryzae (Berk and Broome) Petch gave the best results in both qualitative and quantitative compared to other endolichenic fungi.
EDUCAÇÃO, LAZER E SOCIABILIDADE: memórias e representações sobre a Praça do Imigrante em São Leopoldo/RS (1924-1960)
Authors: Schütz Brito Estela Denise , Dos Reis Duarte Ariane
Published: August 2021

Esta pesquisa tem como objeto de estudo a Praça do Imigrante, localizada na cidade considerada o berço da colonização alemã, São Leopoldo / RS. Em relação aos pressupostos teóricos, a pesquisa está ancorada nos estudos e conceitos vinculados ao campo da História Cultural (CHARTIER, 1990; 2011) e da Geografia Urbana (CARLOS, 2007). Tem como objetivo analisar aspectos relacionados ao espaço denominado de Praça do Imigrante. Como objetivos específicos, busca apontar suas mudanças e transformações no decorrer do tempo e identificar as representações sobre tal espaço nas memórias de sujeitos que o frequentaram no recorte temporal estabelecido. Para isso, foram mobilizados 13 registros fotográficos da praça em diferentes temporalidades, além de narrativas de memórias de alunos que estudaram em regime de internato na Escola Normal Evangélica (ENE) entre as décadas de 1950 e 1960. No decorrer do estudo, foram evidenciadas as transformações ocorridas no espaço da Praça, fruto das intervenções feitas ao longo dos anos. Nesse sentido, observou-se, também, certo afastamento do público em relação a tal espaço. Quanto às memórias dos estudantes da ENE, verificou-se que as práticas escolares e os usos da praça pelos estudantes interligavam o espaço público da praça ao espaço privado da escola, representando, por meio das narrativas, a praça enquanto um espaço de educação, lazer e sociabilidade.
Fiedler vector analysis for particular cases of connected graphs
Authors: Traciná Filho Daniel Felisberto , Justel Claudia Marcela
Published: August 2021

In this paper, we consider a p-Laplacian eigenvalue boundary value problem involving both right Caputo and left Riemann-Liouville types fractional derivatives. To prove the existence of solutions, we apply the Schaefer’s fixed point theorem. Furthermore, we present the Lyapunov inequality for the corresponding problem.
Statistical Analysis on the Impact of BCG Vaccination Policy of Different Economies on Coronavirus
Authors: Modi Aniket
Published: August 2021

The novel coronavirus SARS-Cov-2 (Cov-2) results in COVID-19 infection which affects the respiratory tract of the human body, so we investigated whether the BCG vaccine offers some protection against CoV-2 infection. Herein we examine whether the national programs that use BCG vaccination to reduce tuberculosis infections might be responsible for different incident and mortality rates which is observed in Covid-19 among various countries. There is some mechanistic evidence that shows the BCG vaccination can have some protective effects against the Covid-19 virus. Through our observation, we see that countries that still follow BCG vaccination policy have a significantly lower mortality rate than those countries that have discontinued this policy or never had one.
Enhancing Farm Produce in Punjab through Solar Simulation Model - A Step towards Clean Energy and Green Economy
Authors: Muhammad Yameen
Published: August 2021

In Indian context, the state government is providing subsidized electricity to the farmers to lessen their financial burden and to mitigate the challenge arising due to uncertain weather pattern. But the electricity supply has a limitation of timing and in near future the cost of electricity will certainly increase . On the other hand Indian government has launched many schemes to electrify the rural areas using renewable sources. PM KUSUM yojana being the one which aims to provide the solar panel to the farmers in subsidized cost. In this backdrop the proposed scheme is introduced to provide continuous power supply during day time to do the pumping activity and can able to serve light load during night time. The power generated from the solar PV is utilized to supply the load in sunny hour and the excess power is stored in the battery bank for use in later stage when the solar PV alone cannot meet the load demand. The application of battery bank will remove the dependency upon the grid and can be operated in standalone mode. Thus the present work aims to introduce the Solar PV system with battery bank and investigates the Standalone PV option for reliable, continuous and cost-competitive power supply.
Bioinformatics methods for identifying Hirschsprung disease genes
Authors: Menon Sudheer
Published: August 2021

Hirschsprung is a birth defect of Enteric Nervous System (ENS) which is characterized by the absence of enteric neurons along the length of intestine. Hirschsprung is one of the complex diseases which has become a important topic of human genetics. In this article we have focused on RET gene mutation that is most common cause of HSCR disease. Out of seven mutations in RET gene, one mutation S339L is found to be tolerated and have no effect on protein function.