bluuebunny/crossref_metadata_2025 huggingface dataset:
Dorothy Makes Up Her Mind
Authors: Trollope Anthony
Published: August 2021

IT was true that most ill-natured things had been said at Lessboro’ and at Nuncombe Putney about Mrs. Stanbury and the visitors at the Clock House, and that these ill-natured things had spread themselves to Exeter. Mrs. Ellison of Lessboro’, who was not the most...
The ‘Full Moon’ At St. Diddulph’s
Authors: Trollope Anthony
Published: August 2021

THE receipt of Mrs. Trevelyan’s letter on that Monday morning was a great surprise both to Mr. and Mrs. Outhouse. There was no time for any consideration, no opportunity for delaying their arrival till they should have again referred the matter to Mr. Trevelyan. Their...
Hugh Stanbury Smokes Another Pipe
Authors: Trollope Anthony
Published: August 2021

TREVELYAN was gone, and Bozzle alone knew his address. During the first fortnight of her residence at St. Diddulph’s Mrs. Trevelyan received two letters from Lady Milborough, in both of which she was recommended, indeed tenderly implored, to be submissive to her husband. ‘Anything,’ said...
Shewing What Took Place At St. Diddulph’s
Authors: Trollope Anthony
Published: August 2021

NORA ROWLEY, when she escaped from the violence of her lover, at once rushed up to her own room, and managed to fasten herself in before she had been seen by any one. Her elder sister had at once gone to her aunt when, at...
Shewing What Happened During Miss Stanbury’s Illness
Authors: Trollope Anthony
Published: August 2021

IT was on Christmas-day that Sir Peter Mancrudy, the highest authority on such matters in the west of England, was sent for to see Miss Stanbury; and Sir Peter had acknowledged that things were very serious. He took Dorothy on one side, and told her...
Mr. Outhouse Complains That It’s Hard
Authors: Trollope Anthony
Published: August 2021

LIFE had gone on during the winter at St. Diddulph’s Parsonage in a dull, weary, painful manner. There had come a letter in November from Trevelyan to his wife, saying that as he could trust neither her nor her uncle with the custody of his...
River’s Cottage
Authors: Trollope Anthony
Published: August 2021

THREE days after Hugh Stanbury’s visit to Manchester Street, he wrote a note to Lady Rowley, telling her of the address at which might be found both Trevelyan and his son. As Bozzle had acknowledged, facts are things which may be found out. Hugh had...
Shewing What Hugh Stanbury Thought About The Duty of Man
Authors: Trollope Anthony
Published: August 2021

IN the conference which took place between Sir Marmaduke and his wife after the interview between him and Nora, it was his idea that nothing further should be done at all. ‘I don’t suppose the man will come here if he be told not,’ said...
‘Will They Despise Him?’
Authors: Trollope Anthony
Published: August 2021

GRADUALLY the news of the intended marriage between Mr. Glascock and Miss Spalding spread itself over Florence, and people talked about it with that energy which subjects of such moment certainly deserve. That Caroline Spalding had achieved a very great triumph, was, of course, the...
Bella Victrix
Authors: Trollope Anthony
Published: August 2021

MR. CRUMP arrived at Exeter. Camilla was not told of his coming till the morning of the day on which he arrived; and then the tidings were communicated, because it was necessary that a change should be made in the bed-rooms. She and her sister...
Mr. Glascock as Nurse
Authors: Trollope Anthony
Published: August 2021

A MESSAGE had been sent by the wires*to Trevelyan, to let him know that Mr. Glascock was himself coming for the boy. Whether such message would or would not be sent out to Casalunga Mr. Glascock had been quite ignorant;—but it could, at...
ASSESSMENT OF RADIATION DOSE OF MOBILE COMPUTED TOMOGRAPHY IN INTENSIVE CARE UNITS
Authors: Kim Eunhye , Choi Yoonseok , Park Hyemin , Na Chanyoung , Kim Jungmin , Kim Jungsu , Han Taeho
Published: August 2021

Intra-hospital transport is associated with fatal risks for the occupants of an intensive care unit (ICU). Thus, mobile CT is used in ICUs. In this study, two-dimensional equivalent dose distribution data were expanded using the inverse square law of distance to identify the potential exposure of radiologic technologists and public and the maximum number of possible daily CT procedures. The exposure dose at 1.5 m from the isocentre of the mobile CT was 2.260 μSv. Based on the dose limitation (5 mSv/yr for controlled area and 1 mSv/yr for uncontrolled area) as per National Council on Radiation Protection and Measurement report, the number of possible scans per day was 9 for radiologic technologists and 2 for public. When using the radiation shielding partition with a lead equivalent of 0.3 mmPb, the exposure dose reduced as 0.399 μSv. Therefore, mobile CT can be used in ICUs when appropriate shielding is provided.
Immigrant-Biased Technological Change: The Effect of New Technology Implementation on Native and Non-Western Immigrant Employment in the Netherlands
Authors: ten Berge Jannes , Tomaskovic-Devey Donald
Published: August 2021

This study examines how workplace technological innovation is associated with individual-level employment turnover. We advance the literature by studying how the impact of technology differs for Dutch native workers and workers with non-Western immigrant backgrounds. Furthermore, we examine the disparate impacts of organizational context, as indexed by the proportion of workers with non-Western immigrant backgrounds and workplace job volatility, as well as industry-level unionization. Using large-scale Dutch matched employer–employee longitudinal data for the period 2001–2014, we find technology implementation to decrease chances of job ending, but this innovation protection is smaller and sometimes absent for workers with non-Western immigrant backgrounds than for native Dutch workers. This pattern is most marked for first-generation immigrants and immigrants from non-Dutch-speaking countries. We also find evidence of organization-level ethnic competition effects among low and middle educated workers, but not for workers with tertiary degrees. Among lower educated workers technological displacement is exaggerated in workplaces that employ many workers with immigrant backgrounds, although unionization mutes this effect. Among middle educated workers technological displacement is exaggerated in high-turnover workplaces.
Is Mycobacterium tuberculosis carcinogenic to humans?
Authors: Roy Deodutta , Ehtesham Nasreen Z. , Hasnain Seyed Ehtesham
Published: August 2021

We highlight the ability of the tuberculosis (TB) causing bacterial pathogen, Mycobacterium tuberculosis (Mtb), to induce key characteristics that are associated with established IARC classified Group 1 and Group 2A carcinogenic agents. There is sufficient evidence from epidemiological case‐control, cohort and meta‐analysis studies of increased lung cancer (LC) risk in pre‐existing/active/old TB cases. Similar to carcinogens and other pathogenic infectious agents, exposure to aerosol‐containing Mtb sprays in mice produce malignant transformation of cells that result in squamous cell carcinoma. Convincing, mechanistic data show several characteristics shared between TB and LC which include chronic inflammation, genomic instability and replicative immortality, just to name a few cancer hallmarks. These hallmarks of cancer may serve as precursors to malignant transformation. Together, these findings form the basis of our postulate that Mtb is a complete human pulmonary carcinogen. We also discuss how Mtb may act as both an initiating agent and promoter of tumor growth. Forthcoming experimental studies will not only serve as proof‐of‐concept but will also pivot our understanding of how to manage/treat TB cases as well as offer solutions to clinical conundrums of TB lesions masquerading as tumors. Clinical validation of our concept may also help pave the way for next generation personalized medicine for the management of pulmonary TB/cancer particularly for cases that are not responding well to conventional chemotherapy or TB drugs.
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle
Authors: Petrocelli Jonathan J. , Mahmassani Ziad S. , Fix Dennis K. , Montgomery Jessie A. , Reidy Paul T. , McKenzie Alec I. , de Hart Naomi M. , Ferrara Patrick J. , Kelley Joshua J. , Eshima Hiroaki , Funai Katsuhiko , Drummond Micah J.
Published: August 2021

Loss of muscle mass and strength after disuse followed by impaired muscle recovery commonly occurs with aging. Metformin (MET) and leucine (LEU) individually have shown positive effects in skeletal muscle during atrophy conditions but have not been evaluated in combination nor tested as a remedy to enhance muscle recovery following disuse atrophy in aging. The purpose of this study was to determine if a dual treatment of metformin and leucine (MET + LEU) would prevent disuse‐induced atrophy and/or promote muscle recovery in aged mice and if these muscle responses correspond to changes in satellite cells and collagen remodeling. Aged mice (22–24 months) underwent 14 days of hindlimb unloading (HU) followed by 7 or 14 days of reloading (7 or 14 days RL). MET, LEU, or MET + LEU was administered via drinking water and were compared to Vehicle (standard drinking water) and ambulatory baseline. We observed that during HU, MET + LEU resolved whole body grip strength and soleus muscle specific force decrements caused by HU. Gastrocnemius satellite cell abundance was increased with MET + LEU treatment but did not alter muscle size during disuse or recovery conditions. Moreover, MET + LEU treatment alleviated gastrocnemius collagen accumulation caused by HU and increased collagen turnover during 7 and 14 days RL driven by a decrease in collagen IV content. Transcriptional pathway analysis revealed that MET + LEU altered muscle hallmark pathways related to inflammation and myogenesis during HU. Together, the dual treatment of MET and LEU was able to increase muscle function, satellite cell content, and reduce collagen accumulation, thus improving muscle quality during disuse and recovery in aging.
Prevention and Management of Pseudoverrucous Lesions: A Review and Case Scenarios
Authors: Brogna Luanne
Published: August 2021

Pseudoverrucous lesions are a late peristomal complication that occurs most commonly in people with urinary stomas. Impairment of the peristomal skin can result in pouching system leaks that can translate into odor, embarrassment, and diminished quality of life. Prevention is key to maintaining smooth, dry skin and intact psyche. Treatment revolves around outpatient postoperative follow-up, refitting the pouching system to eliminate moisture impacting the peristomal area, modification of pouching system wear time, acidification of the urine, and intensive education. This review includes three case scenarios to support early, intermediate, and late-stage intervention guidelines. Some interventions were successful; one case remains unresolved.

GENERAL PURPOSE

To present the associated risk factors, prevention measures, and assessment and management of pseudoverrucous lesions specific to a surgically created ileal conduit, as well as three clinical scenarios illustrating this condition.

TARGET AUDIENCE

This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES

After participating in this educational activity, the participant will:

1. Define pseudoverrucous lesions.

2. Identify the risk factors for stoma complications such as pseudoverrucous lesions.

3. Select the appropriate routine care procedures to teach patients following stoma creation to help prevent pseudoverrucous lesions.

4. Choose the recommended treatment options for patients who develop pseudoverrucous lesions.
Pressure-Measuring Devices for Compression Therapy in Venous Leg Ulcers: A Comprehensive Review
Authors: Kruanopparat Rungphet
Published: August 2021

OBJECTIVE

To investigate the evolution of pressure-measuring devices used in compression treatment for venous leg ulcers and assess the most practical and effective devices to determine optimal pressure in compression therapy.

DATA SOURCES

Relevant information was retrieved from databases including Google Scholar, PubMed, Wiley Online, and ScienceDirect without publication date restrictions. The keywords included venous leg ulcer, compression therapy, pressure measuring device, pressure sensor, and wireless system.

STUDY SELECTION

Studies included in the review had to be published in English and discuss or compare pressure-measuring devices/sensors for compression therapy, the development of alternative sensors, and the applications of wireless technologies. Veterinary studies, conference proceedings, and unpublished articles were excluded. Applicable studies and articles were critically evaluated and synthesized.

DATA EXTRACTION

After abstract review, 39 studies were identified. During full-text review, study details were collected using a data extraction form and organized into tables. Device attributes, accuracy, price, and limitations were categorized and analyzed.

DATA SYNTHESIS

Studies disagree on the effectiveness and user-friendliness of existing pressure-measuring devices. These devices often impact user comfort and convenience, which are crucial factors in the adoption and use of wearable devices. Potential solutions for pressure-measuring devices with promising technologies were proposed: four feasible alternative sensors are described that could improve comfort and facilitate prolonged use under bandages. Advanced communication technologies may provide more convenience for users and practitioners.

CONCLUSIONS

Conventional pressure-measuring devices used in compression therapy are not designed for the user’s comfort and convenience. The use of flexible and stretchy pressure sensors (e-skin) provides good biocompatibility, conformability, and comfort and when integrated with near-field communication technology could address the drawbacks of current pressure-measuring devices.
A Multidisciplinary Approach for Tophi Wounds Caused by Glycogen Storage Disease Type 1a: A Rare Case
Authors: Wei Min , Li Jian , Xia Dongyun , Zhou Shaojing , Shen Shanmei , Wen Siyuan , Zhao Guanchun
Published: August 2021

Glycogen storage diseases (GSDs) are a group of rare inherited metabolic disorders caused by enzyme deficiencies in glycogen catabolism. The more common type, GSD type Ia, is caused by glucose-6-phosphatase deficiency and often complicated by gout from hyperuricemia. Here, the authors report a rare case of a tophi wound caused by GSD type Ia in a Chinese patient. Difficulties in this case included the control of abnormal blood markers, especially uric acid; removal of tophi deposited in the tissues; restoration of hand function after wound healing; and patient adherence to treatment and follow-up. A multidisciplinary team was set up consisting of experts from the authors’ wound care center and the departments of endocrinology, orthopedics, and rehabilitation. The wound healed in 53 days and was followed up for about 7 months. During follow-up, the patient’s hand function returned to normal, and no new tophi formed. Because GSDs are a congenital lifelong condition, regular follow-ups are especially important.
The Benefits and Harms of Cleansing for Acute Traumatic Wounds: A Narrative Review
Authors: Wynn Matthew
Published: August 2021

Acute traumatic wound cleansing is currently a controversial issue demonstrated by the variability in solutions and techniques used to clean wounds in clinical practice. Although there is evidence of improved infection outcomes in wounds cleansed with antiseptics, these observations are often undermined by concurrent use of antibiotics in addition to poor study design. Cleansing techniques including pressurized irrigation have also been investigated indicating potential harms such as edema and inconsistencies in irrigation pressures. The purpose of this article is to provide a narrative review on the contemporary evidence indicating the potential harms and benefits of wound cleansing in the context of acute traumatic wounds.

This literature review reveals that acute wound cleansing in clinical practice remains heavily dependent on tradition rather than robust clinical evidence. The evidence base remains limited because of methodological and pragmatic issues in obtaining definitive data on the efficacy of specific agents and techniques. Future studies should focus on establishing the relative benefits of different cleansing solutions and techniques. Establishing the most effective use of antiseptic cleansing solutions may also help reduce further antimicrobial resistance as observed in recent studies. Clinicians responsible for cleansing wounds must consider patient preference when deciding which solution and techniques are used. In addition, a risk assessment considering the potential harms and benefits of different solutions and techniques must be performed.
Distal Radius Fractures and the Dorsal Spanning Plate in the Management of the Polytraumatized Patient
Authors: Golden Ann S. , Kapilow Jaclyn M.
Published: August 2021

Distal radius fractures are some of the most common fractures treated by the orthopaedic surgeon. There are a variety of methods of fixation to treat these fractures; however, in patients with polytrauma and in high-energy fracture patterns, fixation options can be limited. In the past, these fractures were treated with plaster, Kirschner wires, or external fixators that were fraught with complications. The dorsal spanning plate is an excellent option in the treatment of high-energy fractures and patients with polytrauma, fractures with dorsal or volar comminution, fracture dislocations, and shear injuries, and in geriatric patients with poor bone quality. The dorsal spanning plate not only allows for fixation of these complex fractures but also allows for weight-bearing through the wrist, an advantage for patients with concomitant lower extremity fractures and geriatric patients who need mobility aides. Understanding the risks and benefits of dorsal spanning plates and their use for the treatment of polytraumatized patient is a vital base of knowledge for the orthopaedic traumatologist.
Avoiding Complications in Distal Radius Fractures
Authors: Bates Taylor J. , Plucknette Benjamin F.
Published: August 2021

Managing fractures of the distal radius is a fundamental skill for orthopaedic surgeons. Given the prevalence of these fractures, complications following operative management are well described and frequently encountered. Surgeons should be observant in the acute phase for emergent conditions such as acute carpal tunnel syndrome. Careful radiographic examination intra-operatively can help prevent delayed complications by identifying surgical errors such as hardware malposition or malreduction. Many problems that arise during the treatment of distal radius fractures are the result of technical errors and can be anticipated.
Distal Radius Fractures: Recognizing and Treating Complex Fracture Patterns
Authors: Lubbe Ryan J. , Kokmeyer Daniel T. , Young Colby P.
Published: August 2021

Volar fixed-angle plate fixation is a commonly used treatment modality for distal radius fractures. However, not all fracture patterns are amenable to this type of fixation strategy. In this article, we review pertinent anatomy and radiographic landmarks that together highlight key differences when considering treatment strategies for complex distal radius fractures.
Plasma Exchange in Patients With Severe Coronavirus Disease 2019: A Single-Center Experience
Authors: Nusshag Christian , Morath Christian , Speer Claudius , Kaelble Florian , Zeier Martin , Boxberger Monica , Schulze-Schleithoff Elisa , Fiedler Mascha O. , Weigand Markus A. , Merle Uta
Published: August 2021

IMPORTANCE:

Recent evidence suggests a multilevel inflammatory syndrome as a driving factor in some of the most severely ill coronavirus disease 2019 patients with overlapping features to other hyperinflammatory or autoimmune diseases. Therefore, plasma exchange is considered as potential therapy in these patients.

OBJECTIVES:

We characterize the longitudinal therapeutic efficacy and safety profile of plasma exchange in critically ill patients with clinical and laboratory evidences of coronavirus disease 2019–related immunopathology.

DESIGN, SETTING, AND PARTICIPANTS:

A retropsective case-control study of critically ill coronavirus disease 2019 patients treated with plasma exchange at Heidelberg University Hospital between March and December 2020. Plasma exchange–treated patients were compared with coronavirus disease 2019 patients on standard therapy matched for age, gender, disease severity, and features of hyperinflammatory syndrome.

MAIN OUTCOME AND MEASURES:

Mortality rate and course of clinical and laboratory parameters in response to plasma exchange were assessed in coronavirus disease 2019 patients and in patients on standard care. A plasma volume of 50 mL per kg body weight or a maximum of 4 L was exchanged.

RESULTS:

In total, 28 critically ill coronavirus disease 2019 patients were treated with a median of three plasma exchange procedures per patient. No relevant complications occurred during plasma exchange therapy. Inflammatory and biochemical markers of end-organ damage and endothelial activation were significantly reduced following plasma exchange together with normalization of body temperature, improved pulmonary function, and reduced vasopressor demand. Most importantly, these improvements were maintained after the last plasma exchange. In contrast, no such effects were observed in the control group, although baseline clinical and laboratory parameters were comparable. Kaplan-Meier analysis showed improved 30-day survival in the plasma exchange group compared with the control group (67.9% vs 42.9%; p = 0.044). In a multivariable analysis, the hazard ratio for death was 0.27 (95% CI, 0.11–0.68; p = 0.005) with plasma exchange versus standard care.

CONCLUSIONS AND RELEVANCE:

Our data provide further evidence for plasma exchange as a novel therapeutic strategy in a subset of critically ill coronavirus disease 2019 patients by potentially reversing the complex coronavirus disease 2019 immunopathology. Randomized controlled trials are underway to confirm these positive results.
Generating Data Visualizations of Longitudinal Cohort Ambient Air Pollution Exposure
Authors: Castner Jessica , Huntington-Moskos Luz , May Andrew
Published: August 2021

A civic engagement and data science design was used to develop a report-back intervention to address stakeholder concerns related to air emissions surrounding a coke oven factory near Buffalo, NY. This factory had historically emitted high levels of benzene pollution and ceased operation in October 2018 because of violations of the US Clean Air Act and US Resource Conservation and Recovery Act. Using publicly available air pollution and weather data, descriptive time series and wind-rose data visualizations were developed using open-source software as part of a two-page report-back brief. Data from two air toxics monitoring sites in this direction suggest that industrial sources were likely the major contributor to the benzene in the air at these locations prior to May 2018, after which traffic emissions became the likely major contributor. Wind-rose visualizations demonstrated that the wind typically blew toward the northeast, which was qualitatively consistent with locations of stakeholder concerns. With the factory closed, collective efforts subsequently shifted to address traffic emission air pollution sources, factory site cleanup, and ground and water pollution mitigation. Because this intervention utilized open-source software and publicly available data, it can serve as a blueprint for future data-driven nursing interventions and community-led environmental justice efforts.
Antenatal Antidepressant Prescription Associated With Reduced Fetal Femur Length but Not Estimated Fetal Weight
Authors: Schoretsanitis Georgios , Carlini Sara V. , John Majnu , Kane John M. , Deligiannidis Kristina M.
Published: August 2021

Purpose/Background

Antidepressants are among the most frequently prescribed medications during pregnancy and may affect fetal weight. Associations between antenatal antidepressant use and ultrasonographic measures of fetal development have rarely been examined. We hypothesized that the prescription of an antenatal antidepressant would be associated with lower estimated fetal weight (EFW).

Methods/Procedures

A retrospective analysis of routine ultrasonographic data extracted from electronic medical records was performed on a cohort of pregnant women with psychiatric diagnoses and grouped according to the presence of an antenatal antidepressant prescription (n = 32 antidepressant-prescribed and n = 44 antidepressant prescription-free). After stratifying for gestational age, comparisons included 13 ultrasonographic parameters, frequency of oligohydramnios and polyhydramnios and growth deceleration, and maternal serum protein markers assessed per routine care, including α-fetoprotein, free β-human chorionic gonadotropin, and unconjugated estriol levels, using t tests, nonparametric and Fisher tests, and effect sizes (ESs) were computed.

Findings/Results

No statistically significant EFW differences between groups at any time point were detected (P > 0.05). Antenatal antidepressant prescription was associated with lower femur length at weeks 33 to 40 (P = 0.046, ES = 0.75) and greater left ventricular diameter at weeks 25 to 32 (P = 0.04, ES = 1.18). No differences for frequency of oligohydramnios or polyhydramnios or growth deceleration were observed (P > 0.05). We did not detect group differences for maternal proteins (P > 0.05).

Implications/Conclusions

Our evidence suggested a lack of association between antenatal antidepressant prescription and lower EFW but indicated an association with lower femur length and greater left ventricular diameter in mid-late gestation. Future research should examine the clinical implications of these findings.
Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts
Authors: Sainz-Cort Alberto , Jimenez-Garrido Daniel , Muñoz-Marron Elena , Viejo-Sobera Raquel , Heeroma Joost , Bouso Jose Carlos
Published: August 2021

Background

Although δ-9-tetrahydrocannabinol (THC), the main cannabinoid from the cannabis plant, is responsible for the psychotomimetic effects of cannabis, cannabidiol (CBD), the second most abundant cannabinoid in the cannabis plant, does not show any psychotomimetic effect. Cannabidiol has even been proposed to be antipsychotic and to counteract some of the psychotomimetic effects of THC. The aim of this study was to test the potential antipsychotomimetic effects of CBD.

Method

Eighteen members from a cannabis social club were tested for subjective and psychotomimetic effects under the effects of different full-spectrum cannabis extracts containing either THC, CBD, THC + CBD, or placebo in a naturalistic, randomized, double-blind, crossover, placebo-controlled study.

Results

Results showed that participants under the effects of THC + CBD showed lower psychotomimetic scores in subjective scales when compared with THC alone. Subjective scores were lower under the effects of CBD and placebo when compared with THC + CBD. Cannabidiol and placebo did not show any psychotomimetic effect.

Conclusions

This study provides evidence for both the psychotomimetic effects of THC and the antipsychotomimetic effects of CBD when it is coadministered with THC in real-world situations, which can be very relevant for the clinical practice of medical cannabis. Ultimately, this study substantiates the link between the endocannabinoid system and psychotic-like symptoms and has important implications for the understanding of schizophrenia and the therapeutic potential of CBD as an antipsychotic. Lastly, we demonstrate how reliable methodologies can be implemented in real situations to collect valid ecological evidence outside classic laboratory settings.
Improving Outcomes for Work-Related Concussions
Authors: LeGoff Daniel B. , Wright Roslyn , Lazarovic Jacob , Kofeldt Miranda , Peters Aimee
Published: August 2021

Objective:

This study assessed the efficacy of a neurocognitive screening evaluation and brief therapy model to improve RTW outcomes for workers who experienced mild head injuries.

Methods:

Patients referred were evaluated using a neurocognitive and psychological screening battery. Work-focused cognitive behavioral therapy was provided when appropriate, addressing the role of negative emotional adjustment and functional sleep disturbance in prolonging recovery.

Results:

Average time to RTW was 7 weeks post-evaluation, despite workers being off an average of 10 months between injury and referral dates. Overall, 99% were released to full-duty work without restrictions or accommodations.

Conclusions:

This study demonstrates the favorable outcomes achieved via a structured, clinically driven program for workers who experience head-involved injuries, validating previous research on the importance of recognizing the role of psychological factors in prolonging concussion recovery.
COVID-19 Sero-Prevalence and Risk Factors in a Sample of Community Health Center Employees in New York State
Authors: Nolon Anne Kauffman , Ryvicker Miriam , Glassberg Hope , Dubois Allison , Oluwasanmi Oluwatomi , Steier Jessica
Published: August 2021

Objective:

To document COVID-19 sero-prevalence, prior testing, symptom experiences, and risk factors in a sample of community health center (CHC) workers.

Methods:

Descriptive statistics and log-binomial regression were used to analyze an electronic employee survey linked with COVID-19 antibody results. The sample included 378 employees who completed the survey; 325 had complete lab data.

Results:

The sero-positivity rate was 15.4%. One third of sero-positive participants had no previous COVID-19 symptoms or were unsure. Working on-site only and/or with direct patient contact was not associated with sero-positivity. Employees in their 20s were more likely to test positive than employees ages 50+, controlling for sex, race, and region (PR = 2.96; P < 0.05).

Conclusions:

With CHCs central to COVID-19 response and vaccination efforts, public health messaging should remind CHC workers, especially younger employees, of their risks of community-based exposure.
Developing a Competency Framework of Interprofessional Occupational Health Team
Authors: Keshmiri Fatemeh , Mehrparvar Amir Houshang
Published: August 2021

Objective:

The present study aimed to develop a competency framework for interprofessional collaboration in an occupational health team.

Methods:

This study was carried out in three stages. In the first stage, the viewpoints of different stakeholders on the essential competencies of interprofessional team members in occupational health services (OHS) were assessed. In the second stage, extracted codes were converted into competencies in expert panels. After that, the extracted items were categorized by inductive content analysis approach into competency framework. In the third stage, the content validity of interprofessional competencies in OHS was evaluated.

Results:

The competency framework was finalized in six competency domains including prevention, occupational disease management, occupational health assessments, inter-disciplinary and interprofessional collaboration, education, and evidence-based practice and professionalism.

Conclusion:

The framework could be developed in interprofessional education in OHS based on competency-based education approach.
Mortality of Enlisted Men Who Served on Nuclear-Powered Submarines in the United States Navy
Authors: Friedman-Jimenez George , Kato Ikuko , Factor-Litvak Pam , Shore Roy
Published: August 2021

Objective:

To describe the long-term mortality experience of a cohort of enlisted men who served on nuclear-powered submarines in the United States Navy and breathed recirculated filtered air for extended periods of time.

Methods:

In this historical cohort study we estimated standardized mortality ratios (SMRs) and used within-cohort Poisson regression analyses to address healthy worker biases.

Results:

Three thousand two hundred sixty three deaths occurred among 85,498 men during 1,926,875 person-years of follow-up from 1969 to 1995. SMRs were reduced for most cause-of-death categories, prostate cancer had a twofold elevation. In within-cohort comparisons, prostate cancer mortality did not increase with duration of submarine service, but ischemic heart disease mortality increased 26% per 5 years of submarine service.

Conclusions:

Long periods of submarine service do not increase mortality in most cause-of-death categories. Increased mortality from ischemic heart disease likely reflects the effects of tobacco smoke.
Effect of Rehabilitative Ultrasound Imaging (RUSI) Biofeedback on Improving Pelvic Floor Muscle Function in Individuals With Stress Urinary Incontinence: A Systematic Review
Authors: LaCross Jenny , Proulx Laurel , Brizzolara Kelli , Humphrey John
Published: August 2021

Background:

Pelvic floor muscle training is a common intervention for the treatment of stress urinary incontinence (SUI). One method utilized to augment muscle training is biofeedback. Rehabilitative ultrasound imaging (RUSI) is a noninvasive biofeedback tool.

Objectives:

The purpose of this review was to determine the effect of RUSI on pelvic floor muscle function, quality of life, volume of urinary leakage, and severity of urinary leakage in females and males with urinary incontinence and, when possible, compare these results to those of other biofeedback interventions.

Study Design:

Systematic review.

Methods:

PubMed, CINAHL, Science Direct, Scopus, Web of Science, and MEDLINE were searched for titles from peer-reviewed journals and conference proceedings from January 2010 to May 2020. An updated search was performed in January 2021. Inclusion criteria included studies with participants 18 years or older with urinary incontinence. The primary experimental intervention was transabdominal or transperineal RUSI.

Results:

Nine studies were included in this review. The ability to correctly contract the pelvic floor was achieved by more than 95% of participants following RUSI biofeedback training. Although outcomes were not consistently reported, RUSI intervention resulted in a decrease in incontinence severity and number of incontinence episodes per week, as well as improved pelvic floor strength, self-rating of improvement, task-specific self-efficacy, and quality of life.

Conclusion:

The results of this review provide moderate evidence to support the use of RUSI biofeedback via a transabdominal or transperineal approach in males and females with SUI to improve motor performance of the pelvic floor.
Human coagulation factor IX: a systematic review of its characteristics
Authors: Yin Ru , Liu Chen
Published: August 2021

Human coagulation factor IX (FIX) is a vitamin K dependent glycoprotein. It is used in therapy of factor IX deficiency, known as haemophilia B. This article explained the coagulation process involved in FIX and the principle of haemophilia B caused by its absence. We searched and aligned the sequence information of IX in the NCBI's EST database to predict its structure and understand the molecular biological basis of its function. Further, by sorting out the development history of FIX, we summarized the general process of its isolation and purification. Finally, the clinical indications and complications of FIX were overviewed. Through a comprehensive description of the characteristics of FIX, we hope to give readers a clear understanding and put forward our views on the future development of the product.
Clinical characteristics and early prognosis of patients with SARS-CoV-2 infection undergoing joint arthroplasty during the COVID-19 pandemic
Authors: Jin Xin , Chen Mengcun , Wang Jinlong , Yang Shuhua , Xu Weihua , Liu Xianzhe
Published: August 2021

The present study reported early clinical outcomes and perioperative precautions for medical staffs during joint arthroplasty procedures in SARS-CoV-2-infected patients.

The medical records of 8 patients with SARS-CoV-2 infection who underwent joint arthroplasty from January 19 to September 24, 2020 were retrospectively reviewed and analyzed. Perioperative precautions and follow-up (time length varies from 6 month to 13 months, 11 months in average) for SARS-CoV-2 infection of medical staffs were reported.

All patients recovered well from both the primary disease and SARS-CoV-2 infection. Significant improved Visual analogue scale was observed with no major complications or recurrence of the COVID-19 at discharge. There was no evidence indicating SARS-CoV-2 infection in any health providers.

Elective joint arthroplasties for patients in recovery period of SARS-CoV-2 infection could be continued under comprehensive preoperative evaluation and appropriate medical protection. For patients with currently confirmed or highly suspected COVID-19, the operation should be carried out only if it was essential.
Effect of Ma Yinglong Shexiang hemorrhoids cream combined with pearl powder on the pain and complications of severe pressure ulcer patients
Authors: Niu Dongling
Published: August 2021

Objective:

The aim of this study was to investigate the effect of Ma Yinglong Shexiang Hemorrhoids Cream combined with pearl powder on pain and complications in patients with severe pressure ulcers.

Methods:

One hundred seventeen patients with severe pressure ulcers hospitalized and treated in our hospital (January 2019--December 2019) were divided into Ma Yinglong Musk Hemorrhoid Cream Group (MY Group), Pearl Powder Group (PP Group), and combination with Ma Yinglong Musk Hemorrhoid Cream and Pearl Powder Group (MP group), 39 patients in each group. There was no significant difference in the general data of patients in MY group, PP group, and MP group. By analyzing the differences in clinical efficacy, secondary effects, scar incidence, pain, and clinical indicators of patients in the MY group, PP group, and MP group, the effects of Mayinglong Shexiang Hemorrhoid Cream combined with pearl powder in the treatment of pain and complications in patients with severe pressure ulcers were explored.

Results:

After treatment, compared with the MY group and the PP group, the MP group had a higher clinical efficacy than the MY group and the PP group. Compared with MY group and PP group, the healing time, dressing change times, and dressing change time of MP group were better than MY group (P < .05). After treatment, the VAS score and incidence of secondary effects of the MP group was significantly lower than that of the MY group and PP group (P < .05). The incidence and area of scar formation in the MP group were lower than those in the MY group and the PP group (P < .05).

Conclusion:

Compared with Ma Yinglong Musk Hemorrhoid Cream or Pearl Powder, combination of Ma Yinglong Musk Hemorrhoid Cream and Pearl Powder are more effective in treating severe pressure ulcer patients, and can significantly reduce the pain in the affected area and reduce the occurrence of complications.
Multidimensional analyses of the effect of exercise on women with depression
Authors: Yan Lin-Bo , Zhang Jing-Zhi , Zhou Qian , Peng Feng-Lin
Published: August 2021

Background:

The proportion of women is higher than men in depression. This is mainly due to women's physiological regulation is different from men, especially in puberty, menstruation, pregnancy, menopause, among others. Therefore, treating depressive women is still a health challenge. Besides, recent studies of exercise therapy have a more outstanding performance in treating depression, especially in contrast to drug therapy and psychotherapy. Its main advantages are convenience, quickness, no side effects, real-time, and long-term effectiveness.

Objective:

The aim of this study was to systematically review the clinical efficacy of exercise on women with depressive symptoms.

Methods:

Searching PubMed, The Cochrane Library, and Embase databases to collect randomized controlled trials about exercise in the treatment of depressive women. After literature screening, data extraction, and literature quality evaluation, the meta-analysis of acquirement data was performed with RevMan5.3 software.

Results:

A total of 2294 patients were included in 25 different articles totally. Meta-analysis shows that compared with the control group, exercise could relieve female depression (standard mean difference [95% confidence interval, CI] = −0.64 [−0.89 to −0.39], Z = 4.99, P < .001). Subgroup analysis shows that different types of exercise have significant effects in improving depression symptoms. Exercise therapy has better effect on depressive patients induced by physiology or disease than ordinary depressive patients.

Conclusion:

Exercise can significantly improve depressive symptoms in women.
Effect of aspirin use on survival benefits of breast cancer patients
Authors: Liu Jiamin , Zheng Fengxian , Yang Meng , Wu Xiaoyong , Liu Aimin
Published: August 2021

Objective:

The purpose of this study is to investigate whether aspirin improves the prognosis of breast cancer patients by meta analysis.

Methods:

Searched PubMed, EMBASE, and other databases for literature on the relationship between aspirin use and breast cancer prognosis, with the deadline of October 2019. The related results of all-cause death, breast cancer-specific death, and breast cancer recurrence/metastasis were extracted to combine the effect amount. The sensitivity analysis and published bias analysis were carried out for the included data. Stata12.0 software was used to complete all statistical analysis.

Results:

A total of 13 papers were included in the study, including 142,644 breast cancer patients. The results of meta-analysis showed that patients who took aspirin were associated with lower breast cancer-specific death (HR = 0.69, 95% CI = 0.61–0.76), all-cause death (HR = 0.78, 95% CI = 0.71–0.84), and risk of recurrence/metastasis (HR = 0.91, 95% CI: 0.82–1.00).

Conclusions:

Aspirin use may improve all-cause mortality, specific mortality, and risk of recurrence/metastasis in patients with breast cancer.
Elevated homocysteine levels in patients with heart failure
Authors: Jin Nake , Huang Lei , Hong Jun , Zhao Xuechen , Chen Yujiao , Hu Jianan , Cong Xin , Xie Yuquan , Pu Jun
Published: August 2021

Background:

Elevated homocysteine (Hcy) levels showed increasing significance as the predisposing factor for the pathogenesis of atherosclerotic sequelae, including cardiovascular mortality, coronary artery disease, and stroke. There is increasing evidence linking plasma Hcy levels and heart failure (HF). The association between the elevated level of plasma Hcy and HF was examined by meta-analysis and systematic review in this study.

Methods:

The PubMed and ScienceDirect databases until April 2020 were utilized to collect previous literature on plasma Hcy levels and the potential relation to HF. The pooled effects were evaluated depending on standardized mean differences (SMDs) with 95% confidence intervals (CIs), and the calculation was performed using Stata 12 software. Potential sources of heterogeneity were assessed with subgroup analysis and sensitivity analysis.

Results:

A total of 12 research projects including 5506 subjects were selected. For pooled effect, the results confirmed that patients with HF had higher Hcy levels than the control subjects (SMD,1.148 and 95%CI, [0.715, 1.581]). Based on the classification of New York Heart Association (NYHA), the Hcy levels for the group of NYHA I or II (SMD, 1.484 and 95% CI, [0.442, 2.527]) and the group of NYHA III or IV (SMD, 3.361 and 95% CI, [1.902, 4.820]) were significantly increased compared to controls, while the increase was more intensive for the group of NYHA III or IV. Subgroup analyses revealed similar results.

Conclusion:

Our meta-analysis identified that plasma Hcy levels were significantly elevated in HF patients compared to control subjects, which is positively related to the advancement of NYHA class.
A prognostic scoring system for operated acute epidural hematoma based on gray–white matter ratio
Authors: Luo Yunxing , He Xiwu , Yang Mingfei , Du Chaonan , Jin Xiaoqing
Published: August 2021

To determine the prognostic risk factors of patients with acute epidural hematoma (AEDH), a scoring system was established based on gray–white matter ratio (GWR) and internal verification was performed.

All patients with AEDH who underwent surgical treatment in Qinghai Provincial People's Hospital from January 2013 to June 2019 were continuously collected. The clinical and imaging data of the patients were collected. According to Glasgow Outcome Scale at 3 months after operation, the patients were divided into poor and good prognosis groups, respectively. The GWR value of the nonhematoma side was measured at the inner capsule area. Univariate and multivariate analyses were used. Independent predictors significantly related to the prognosis of AEDH were screened out and a nomogram was established based on these factors.

A total of 170 cases were included in this study, the Glasgow Coma Score (severe and moderate), cerebral hernia, midline shift, preoperative GWR, postoperative GWR, hematoma thickness/midline shift, time from coma to surgery, and decompression of bone flap were the independent risk factors for predicting the poor prognosis of AEDH. Moreover, the prediction ability of nomogram was higher than any other independent predictive factors.

The nomogram model established represents the most effective factor to predict the prognosis of operated AEDH. The scoring system is characterized by high accuracy, simplicity and feasibility, with a wide range of clinical application prospects.
Long non-coding RNA as a potential biomarker for prognosis of glioma
Authors: Xie Teng , Li Bin , Liu Huaming , Zhang Chunwei , Wang Yanhua , Chen Zhijun , Yan Junping
Published: August 2021

Background:

The molecular mechanism of Glioma is still unclear, and there are few early diagnostic markers. Therefore, it is urgent to figure out effective preventive measures, active diagnostic methods and rapid treatment measures. In recent years, relevant studies have revealed that long non-coding RNA (lncRNA) is associated with the prognosis of Glioma. However, these results have not been supported by any evidence. Therefore, this study carried out a meta-analysis method to analyze the relationship between lncRNA and the prognosis of Glioma. In addition, bioinformatics analysis was conducted to investigate the mechanism and related pathways of lncRNAs in Glioma.

Methods:

We performed a systematic search in electronic databases, including China National Knowledge Infrastructure, Chinese Biomedical literature Database, Chinese Scientific and Journal Database, Wan Fang database, PubMed, EMBASE, Cochrane Library and Web of Science, to investigate the potential association between lncRNA expression and prognostic significance and clinical features in glioma patients. Hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) were pooled to estimate the prognosis value of lncRNA by Stata16.0 software. The online tool AnnoLnc was applied to screen the co-expressed gene related to each lncRNA, David was used for gene ontology (GO) analysis and enrichment analysis of the signal pathway, and through Starbase, the possible competitive endogenous RNA network of lncRNAs was constructed.

Results:

The results of this meta-analysis would be submitted to peer-reviewed journals for publication.

Conclusion:

This study will provide evidence-based medical evidence for lncRNA, so as to predict the prognosis of Glioma and bioinformatics analysis will provide ideas for the mechanism study on Glioma.