bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacomicrobiomics: Immunosuppressive Drugs and Microbiome Interactions in Transplantation
Authors: Mohamed Moataz E. , Saqr Abdelrahman , Staley Christopher , Onyeaghala Guillaume , Teigen Levi , Dorr Casey R. , Remmel Rory P. , Guan Weihua , Oetting William S. , Matas Arthur J. , Israni Ajay K. , Jacobson Pamala A.
Published: February 2024

The human microbiome is associated with human health and disease. Exogenous compounds, including pharmaceutical products, are also known to be affected by the microbiome, and this discovery has led to the field of pharmacomicobiomics. The microbiome can also alter drug pharmacokinetics and pharmacodynamics, possibly resulting in side effects, toxicities, and unanticipated disease response. Microbiome-mediated effects are referred to as drug–microbiome interactions (DMI). Rapid advances in the field of pharmacomicrobiomics have been driven by the availability of efficient bacterial genome sequencing methods and new computational and bioinformatics tools. The success of fecal microbiota transplantation for recurrent Clostridioides difficile has fueled enthusiasm and research in the field. This review focuses on the pharmacomicrobiome in transplantation. Alterations in the microbiome in transplant recipients are well documented, largely because of prophylactic antibiotic use, and the potential for DMI is high. There is evidence that the gut microbiome may alter the pharmacokinetic disposition of tacrolimus and result in microbiome-specific tacrolimus metabolites. The gut microbiome also impacts the enterohepatic recirculation of mycophenolate, resulting in substantial changes in pharmacokinetic disposition and systemic exposure. The mechanisms of these DMI and the specific bacteria or communities of bacteria are under investigation. There are little or no human DMI data for cyclosporine A, corticosteroids, and sirolimus. The available evidence in transplantation is limited and driven by small studies of heterogeneous designs. Larger clinical studies are needed, but the potential for future clinical application of the pharmacomicrobiome in avoiding poor outcomes is high.
Delayed Graft Function and the Renin-Angiotensin System
Authors: Yamani Fatmah , Cianfarini Cosimo , Batlle Daniel
Published: February 2024

Delayed graft function (DGF) is a form of acute kidney injury (AKI) and a common complication following kidney transplantation. It adversely influences patient outcomes increases the financial burden of transplantation, and currently, no specific treatments are available. In developing this form of AKI, activation of the renin-angiotensin system (RAS) has been proposed to play an important role. In this review, we discuss the role of RAS activation and its contribution to the pathophysiology of DGF following the different stages of the transplantation process, from procurement and ischemia to transplantation into the recipient and including data from experimental animal models. Deceased kidney donors, whether during cardiac or brain death, may experience activation of the RAS. That may be continued or further potentiated during procurement and organ preservation. Additional evidence suggests that during implantation of the kidney graft and reperfusion in the recipient, the RAS is activated and may likely remain activated, extrapolating from other forms of AKI where RAS overactivity is well documented. Of particular interest in this setting is the status of angiotensin-converting enzyme 2, a key RAS enzyme essential for the metabolism of angiotensin II and abundantly present in the apical border of the proximal tubules, which is the site of predominant injury in AKI and DGF. Interventions aimed at safely downregulating the RAS using suitable shorter forms of angiotensin-converting enzyme 2 could be a way to offer protection against DGF.
Glucagon-like Peptide 1 Receptor Agonists and Cardiovascular Outcomes in Solid Organ Transplant Recipients With Diabetes Mellitus
Authors: Dotan Idit , Rudman Yaron , Turjeman Adi , Akirov Amit , Steinmetz Tali , Calvarysky Bronya , Diker Cohen Talia
Published: February 2024

Background.

Glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce cardiovascular events and mortality in type 2 diabetes. Limited data are available on diabetes treatment after solid organ transplantation. We aimed to explore the effect of GLP1-RAs on cardiovascular outcomes in transplanted recipients with diabetes.

Methods.

We extracted data on adult transplant recipients (kidney, lungs, liver, heart) insured in a large health maintenance organization. Death-censored patients with diabetes treated with GLP1-RAs were matched with nonusers. The primary outcome was a composite of major cardiovascular events (MACEs): a nonfatal cardiac event (myocardial infarction, stable/unstable angina, coronary bypass, and coronary angiography), ischemic stroke and all-cause mortality. Secondary outcomes were MACE or peripheral vascular disease (MACE-PVD), and all-cause mortality. Safety outcomes included biliopancreatic adverse events.

Results.

We included 318 patients (69% males, average age 58.3 ± 11.0 y) with a 3.1-y median follow-up. The incidence of MACE was 101 of 1000 patient-years in GLP1-RAs users compared with 134 of 1000 in controls (hazard ratio [HR] 0.46; 95% confidence interval [CI], 0.27-0.78). GLP1-RAs similarly reduced the risk of MACE-PVD (HR 0.53; 95% CI, 0.33-0.88) and the risk of all-cause mortality (HR 0.39; 95% CI, 0.18-0.84). Biliopancreatic adverse events occurred less in GLP1-RA users.

Conclusions.

Transplant recipients with diabetes who used GLP1-RAs had lower risks for MACE and all-cause mortality. These results may profoundly implicate the daily management of posttransplant recipients with diabetes, a population with a high prevalence of cardiometabolic risk factors and cardiovascular death. Transplant patients are usually excluded from randomized controlled trials and, hence might be undertreated with disease-modifying drugs. Larger prospective studies are needed in this unique population.
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis
Authors: Ambrosius-Eichner J. , Hogardt M. , Berger A. , Dultz G. , Idris R. , Kempf V.A.J. , Wichelhaus T.A.
Published: February 2024

Introduction. Infectious gastroenteritis is a common reason for consulting a physician. Although most cases of gastrointestinal illness are self-limiting, the identification of the etiologic pathogen by stool specimen analysis is important in cases of more severe illness and for epidemiological reasons.

Due to the broad range of causative pathogens, the conventional examination of a stool specimen is labour-intensive and usually requires different diagnostic methods. Multiplex PCR tests [e.g. BioFire Gastrointestinal (GI) Panel] allow the rapid detecting of up to 22 pathogens in one test.

Hypothesis. Using a multiplex PCR panel to test stool specimens for infectious gastroenteritis pathogens can improve the detection rate, reduce the time-to-result and hands-on time and lower the costs of a microbiology laboratory.

Aim. This study was aimed at evaluating the detection rate, the workflow and associated costs of stool specimen management using the BioFire GI Panel versus conventional methods.

Methodology. Stool specimens were evaluated prospectively during the routine operation. Pathogen detection rate, hands-on time, time-to-result and material and personnel costs were determined for the BioFire GI Panel and conventional methods—the latter based on physician request and excluding viral testing.

Results. Analysing 333 specimens collected between 2019 and 2020, the detection rate of enteropathogens was significantly higher with a positivity rate of 39.9 % using the multiplex PCR panel compared with 15.0 % using the conventional methods. The BioFire GI Panel presented results in a median time of 2.2 h compared with 77.5 h for culture and 22.1 h for antigen testing, noting that no tests were performed at weekends except for toxinogenic Clostridioides difficile. Based on list prices, the BioFire GI Panel was nine times more expensive compared with conventional methods, whereas hands-on-time was significantly lower using the BioFire GI Panel.

Conclusion. Multiplex PCR panels are valuable tools for laboratory identification of infectious agents causing diarrhoea. The higher costs of such a multiplex PCR panel might be outweighed by the higher detection rate, ease of handling, rapid results and most likely improved patient management. However, these panels do not provide information on antimicrobial susceptibility testing. Therefore, if this is necessary for targeted therapy or if outbreak monitoring and control is required, specimens must still be cultured.
A Spatial Prioritization of Conifer Management to Defend and Grow Sagebrush Cores
Authors: Reinhardt Jason R. , Maestas Jeremy D. , Naugle David E. , Bedrosian Geoffrey , Doherty Kevin E. , Kumar Alexander V.
Published: February 2024

Sagebrush ecosystems across the western U.S. are in decline due to numerous threats, including expansion of coniferous woodlands and forests. The interagency Sagebrush Conservation Design effort recently quantified sagebrush ecological integrity (SEI) to map remaining core sagebrush areas (relatively intact and functional sagebrush ecosystems) and understand spatial and temporal patterns of change relative to primary threats. This work identified conifer expansion as the second leading cause of decline in sagebrush ecological integrity biome wide. Here, we sought to create a spatial prioritization of conifer management that maximizes return-on-investment to defend and grow core sagebrush areas. Multi-criteria decision analysis (MCDA) was used to incorporate a series of biome-level inputs including SEI, invasive annual grass cover and risk, structural connectivity, and conifer cover and expansion vulnerability into a single prioritization based on collaborative expert input. Our analysis identifies priority areas for conifer management across the sagebrush biome, simulates conifer treatments based on those priorities, and estimates potential changes in SEI as a result of targeted treatment. At a broad scale, we found that the highest priority areas for conifer management were largely located east of the Rocky Mountains. This represents a departure from recent landscape-level trends conifer management efforts in sagebrush systems, which were focused primarily pinyon-juniper expansion in the Great Basin. A majority (52%) of the highest priority areas are managed by the Bureau of Land Management, followed by a large proportion (26%) of priority areas located on privately-owned land – particularly in Wyoming and Montana. Targeting simulated conifer treatments using our prioritization resulted in higher within-core targeting percentages (≥93%) than business-as-usual efforts (23.8%), which would result in a four- to eight-fold reduction in the time to treat priority areas within cores. Finally, we demonstrate that these simulated treatments, targeted with our prioritization, have the capacity to improve SEI in and around treatment areas. This work provides an actionable path to “Defend the Core” as outlined by the Sagebrush Conservation Design effort by helping conservationists more efficiently address conifer expansion in and around core sagebrush areas.
Multiomics uncovers the epigenomic and transcriptomic response to viral and bacterial stimulation in turbot
Authors: Aramburu Oscar , Gómez-Pardo Belén , Rodríguez-Villamayor Paula , Blanco-Hortas Andrés , Lamas Jesús , Dewari Pooran , Perojil-Morata Diego , Boudinot Pierre , Macqueen Daniel J. , Bouza Carmen , Martínez Paulino
Published: February 2024

Uncovering the epigenomic regulation of immune responses is essential for a comprehensive understanding of host defence mechanisms, though remains poorly investigated in farmed fish. We report the first annotation of the innate immune regulatory response in the turbot genome (Scophthalmus maximus), integrating RNA-Seq with ATAC-Seq and ChIP-Seq (H3K4me3, H3K27ac and H3K27me3) data from head kidney (in vivo) and primary leukocyte cultures (in vitro) 24 hours post-stimulation with viral (poly I:C) and bacterial (inactiveVibrio anguillarum) mimics. Among the 8,797 differentially expressed genes (DEGs), we observed enrichment of transcriptional activation pathways in response to Vibrio and immune pathways - including interferon stimulated genes - for poly I:C. We identified notable differences in chromatin accessibility (20,617 in vitro, 59,892 in vivo) and H3K4me3-bound regions (11,454 in vitro, 10,275 in vivo) between stimulations and controls. Overlap of DEGs with promoters showing differential accessibility or histone mark binding revealed significant coupling of the transcriptome and chromatin state. DEGs with activation marks in their promoters were enriched for similar functions to the global DEG set, but not always, suggesting key regulatory genes being in poised state. Active promoters and putative enhancers were enriched in specific transcription factor binding motifs, many common to viral and bacterial responses. Finally, an in-depth analysis of immune response changes in chromatin state surrounding key DEGs encoding transcription factors was performed. This multi-omics investigation provides an improved understanding of the epigenomic basis for the turbot immune responses and provides novel functional genomic information, leverageable for disease resistance selective breeding.
UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth
Authors: Drozd Cody J. , Chowdhury Tamjid A. , Quinn Christopher C.
Published: February 2024

MAPK8IP3 (unc-16/JIP3)is a neurodevelopmental-disorder associated gene that can regulate the termination of axon growth. However, its role in this process is not well understood. Here, we report that UNC-16 promotes axon termination through a process that includes the LRK-1(LRRK-1/LRRK-2) kinase and the WDFY-3 (WDFY3/Alfy) selective autophagy protein. Genetic analysis suggests that UNC-16 promotes axon termination through an interaction between its RH1 domain and the dynein complex. Loss ofunc-16function causes accumulation of late endosomes specifically in the distal axon. Moreover, we observe synergistic interactions between loss ofunc-16function and disruptors of endolysosomal function, indicating that the endolysosomal system promotes axon termination. We also find that the axon termination defects caused by loss of UNC-16 function require the function of a genetic pathway that includeslrk-1andwdfy-3, two genes that have been implicated in autophagy. These observations suggest a model where UNC-16 promotes axon termination by interacting with the endolysosomal system to regulate a pathway that includes LRK-1 and WDFY-3.
Lysosomal uptake of mtDNA mitigates heteroplasmy
Authors: Kakanj Parisa , Bonse Mari , Gökmen Aylin , Gaedke Felix , Mollá Belén , Vogelsang Elisabeth , Schauss Astrid , Wodarz Andreas , Pla-Martín David
Published: February 2024

Mitochondrial DNA is exposed to multiple insults produced by normal cellular function. Upon mtDNA replication stress the mitochondrial genome transfers to endosomes where it is degraded. Here, using proximity proteomics we found that mtDNA replication stress leads to the rewiring of the mitochondrial proximity proteome, increasing mitochondria association with lysosomal and vesicle-associated proteins, such as the GTPase RAB10 and the retromer. We found that upon mtDNA replication stress, RAB10 enhances mitochondrial fragmentation and relocates from the ER to lysosomes containing mtDNA. The retromer enhances and coordinates the expulsion of mitochondrial matrix components through mitochondrial-derived vesicles, and mtDNA with direct transfer to lysosomes. Using aDrosophilamodel carrying a long deletion on the mtDNA (ΔmtDNA), we evaluatedin vivothe role of the retromer in mtDNA extraction and turnover in the larval epidermis. The presence of ΔmtDNA elicits the activation of a specific transcriptome profile related to counteract mitochondrial damage. Expression of the retromer componentVps35is sufficient to restore mtDNA homoplasmy and mitochondrial defects associated with ΔmtDNA. Our data reveal novel regulators involved in the specific elimination of mtDNA. We demonstrate that modulation of the retromerin vivois a successful mechanism to restore mitochondrial function associated with mtDNA damage.
Macroscopic quantum entanglement between an optomechanical cavity and a continuous field in presence of non-Markovian noise
Authors: Direkci S. , Winkler K. , Gut C. , Hammerer K. , Aspelmeyer M. , Chen Y.
Published: February 2024

Probing quantum entanglement with macroscopic objects allows us to test quantum mechanics in new regimes. One way to realize such behavior is to couple a macroscopic mechanical oscillator to a continuous light field via radiation pressure. In view of this, the system that is discussed comprises an optomechanical cavity driven by a coherent optical field in the unresolved sideband regime where we assume Gaussian states and dynamics. We develop a framework to quantify the amount of entanglement in the system numerically. Different from previous work, we treat non-Markovian noise and take into account both the continuous optical field and the cavity mode. We apply our framework to the case of the Advanced Laser Interferometer Gravitational-Wave Observatory and discuss the parameter regimes where entanglement exists, even in the presence of quantum and classical noises.

Published by the American Physical Society
2024
Separable graph Hamiltonian network: A graph deep learning model for lattice systems
Authors: Geng Ru , Zu Jian , Gao Yixian , Zhang Hong-Kun
Published: February 2024

Addressing the challenges posed by nonlinear lattice models, which are vital across diverse scientific disciplines, we present a new deep learning approach that harnesses the power of graph neural networks. By representing the lattice system as a graph and leveraging the graph structures to identify complex nonlinear relationships, we have developed a flexible solution that outperforms traditional techniques. Our model not only offers precise trajectory predictions and energy conservation properties by incorporating separable Hamiltonians but also proves superior to existing top-tier models when tested on classic nonlinear oscillator lattice problems: a mixed Fermi-Pasta-Ulam Klein-Gordon, a Klein-Gordon system with long-range interactions, and a two-dimensional Frenkel-Kontorova, highlighting its potential for wide-reaching applications.

Published by the American Physical Society
2024
Scaling adaptive quantum simulation algorithms via operator pool tiling
Authors: Van Dyke John S. , Shirali Karunya , Barron George S. , Mayhall Nicholas J. , Barnes Edwin , Economou Sophia E.
Published: February 2024

Adaptive variational quantum simulation algorithms use information from a quantum computer to dynamically create optimal trial wave functions for a given problem Hamiltonian. A key ingredient in these algorithms is a predefined operator pool from which trial wave functions are constructed. Finding suitable pools is critical for the efficiency of the algorithm as the problem size increases. Here, we present a technique called operator pool tiling that facilitates the construction of problem-tailored pools for arbitrarily large problem instances. By first performing an Adaptive Derivative-Assembled Problem-Tailored Ansatz Variational Quantum Eigensolver (ADAPT-VQE) calculation on a smaller instance of the problem using a large, but computationally inefficient, operator pool, we extract the most relevant operators and use them to design more efficient pools for larger instances. We demonstrate the method here on strongly correlated quantum spin models in one and two dimensions, finding that ADAPT automatically finds a highly effective ansatz for these systems. Given that many problems, such as those arising in condensed matter physics, have a naturally repeating lattice structure, we expect the pool tiling method to be a widely applicable technique apt for such systems.

Published by the American Physical Society
2024
Quantifying bunch-mode influence on photon-counting detectors at SPring-8
Authors: Imai Yasuhiko , Hatsui Takaki
Published: February 2024

Count-loss characteristics of photon-counting 2D detectors are demonstrated for eight bunch-modes at SPring-8 through Monte Carlo simulations. As an indicator, the effective maximum count rate was introduced to signify the X-ray intensity that the detector can count with a linearity of 1% or better after applying a count-loss correction in each bunch-mode. The effective maximum count rate is revealed to vary depending on the bunch-mode and the intrinsic dead time of the detectors, ranging from 0.012 to 0.916 Mcps (megacounts per second) for a 120 ns dead time, 0.009 to 0.807 Mcps for a 0.5 µs dead time and 0.020 to 0.273 Mcps for a 3 µs intrinsic detector dead time. Even with equal-interval bunch-modes at SPring-8, the effective maximum count rate does not exceed 1 Mcps pixel−1. In other words, to obtain data with a linearity better than 1%, the maximum intensity of X-rays entering the detector should be reduced to 1 Mcps pixel−1 or less, and, in some cases, even lower, depending on the bunch-mode. When applying count-loss correction using optimized dead times tailored to each bunch-mode, the effective maximum count rate exceeds the values above. However, differences in the effective maximum count rate due to bunch-modes persist. Users of photon-counting 2D detectors are encouraged to familiarize themselves with the count-loss characteristics dependent on bunch-mode, and to conduct experiments accordingly. In addition, when designing the time structure of bunch-modes at synchrotron radiation facilities, it is essential to take into account the impact on experiments using photon-counting 2D detectors.
Consumers’ valuation of blockchain-based food traceability: role of consumer ethnocentrism and communication via QR codes
Authors: Tran Duc , De Steur Hans , Gellynck Xavier , Papadakis Andreas , Schouteten Joachim J.
Published: February 2024

Purpose

This study aims to investigate the impact of consumer ethnocentrism on consumers' evaluation of blockchain-based traceability information. It also examined how the use of quick response (QR) codes for traceability affects consumers' evaluation of traceable food products.

Design/methodology/approach

An online choice experiment was conducted to determine consumers' evaluation of the blockchain-based traceability of Feta cheese with a quota sample of 715 Greek consumers. Pearson bivariate correlation and mean comparison were used to examine the relationship between consumer ethnocentrism and QR use behaviour. Random parameter logit models were employed to examine consumers’ valuation of the examined attributes and interaction terms.

Findings

The results show that ethnocentric consumers are willing to pay more for blockchain-based traceability information. Ethnocentric consumers tend to scan QR codes with traceability information. Spending more time reading traceability information embedded in QR codes does not lead to a higher willingness-to-pay (WTP) for traceable food products.

Practical implications

The findings suggest that patriotic marketing messages can draw consumers' attention to blockchain-based traceability information. The modest WTP for and low familiarity with blockchain-based traceability systems raise the need for educating consumers regarding the benefits of blockchain in traceability systems.

Originality/value

This is the first study to provide timely empirical evidence of a positive WTP for blockchain-based traceability information for a processed dairy product. This study is the first to attempt to distinguish the effects of the intention to scan QR codes and reading information embedded in QR codes on consumers’ valuation of food attributes.
Community and governmental perspectives on climate disaster risk finance instruments in Colombia
Authors: Fernández Lopera Cristian Camilo , Mendes José Manuel , Barata Eduardo Jorge , Trejo-Rangel Miguel Angel
Published: February 2024

Purpose

At the global level, disaster risk finance (DRF) is playing an increasingly prominent role in the international agendas for climate change adaptation. However, before implementing such agendas, it is essential to understand the needs and limitations of DRF in the subnational context where they need to impact. This research aims to gain insights into the perspectives of community and governmental actors in Colombia regarding DRF. Its goal is to promote the specific design of collaborative educational and technical assistance processes that consider their interests in the subject and the cultural diversity of the territories.

Design/methodology/approach

To achieve this, semi-structured interviews were conducted, and the findings were organized to highlight key aspects that help to understand DRF perspectives in the Colombian context.

Findings

It was found that the most significant limitations of implementing DRF include a lack of knowledge on the topic, corruption that encourages a reactive approach and the absence of economic resources. Concerns have emerged regarding the possibility of climate risk insurance becoming a profit-driven enterprise and the potential development of dependency behaviors within community groups, leading to maladaptation and moral hazard. Similarly, the implementation of DRF through foreign funds has raised concerns about the loss of territorial sovereignty and autonomy.

Originality/value

This is one of the first studies that carry out this kind of research and contributes to the formulation of inclusive public policies for DRF in different contexts worldwide.
A decision-support framework for suspension of public infrastructure projects: a combined use of neutrosophic AHP and TOPSIS
Authors: Okudan Ozan , Demirdöğen Gökhan , Işık Zeynep
Published: February 2024

Purpose

The purpose of this study is to develop a decision-support framework that can be used by decision-makers to suspend public infrastructure projects. Additionally, the study also investigates how to select the most convenient infrastructure project for suspension.

Design/methodology/approach

The proposed framework includes an extensive set of factors and a novel comparison mechanism that can reveal the most convenient infrastructure project to be suspended. A comprehensible literature review and focus group discussion (FGD) sessions were conducted to identify factors that should be considered for suspension. Then, the neutrosophic analytic hierarchy process (N-AHP) method was used to determine the relative importance of the factors. Finally, the proposed comparison mechanism was demonstrated through a hypothetical case study and Technique for order of preference by similarity to ideal solution (TOPSIS) analysis.

Findings

Results showed that suspension decisions cannot be made merely based on “financial” factors. Instead, the other aspects, namely “Technical and managerial” and “Social and Environmental”, should also be taken into consideration. Second, factors related to the initial investment, cost of refinancing, cash flow, permits and approvals, insufficiency of bidders, degradation of the components, reputation, impact on stakeholders and criticality of the infrastructure were particularly elaborated as the most significant, needing the utmost attention of the decision-makers. Lastly, the results demonstrated that the proposed comparison mechanism has considerable potential to identify the most convenient infrastructure project for suspension.

Originality/value

Public infrastructure projects are often under pressure due to the inflationary state and economic stagnation of countries after major crises. The suspension decision for infrastructure projects necessitates comprehensible assessments to consider all consequences. Studies have widely investigated the contractual and legal aspects of project suspension in light of existing literature. However, little effort has been devoted to identifying the factors that decision-makers should consider before suspending a particular infrastructure project. Furthermore, existing literature does not investigate how to select the most convenient infrastructure project for suspension either. Thus, by developing a specific suspension framework for infrastructure projects by considering various factors, this study is the earliest attempt to examine the contract suspension mechanism of public infrastructure projects. In this respect, the study significantly contributes to the theory of contract management domain and has important managerial implications.
How social media usage and the fear of missing out impact minimalistic consumption
Authors: Lu Fang-Chi , Sinha Jayati
Published: February 2024

Purpose

This study aims to examine the influence of social media usage (SMU) on minimalist consumption and how the fear of missing out (FoMO) underlies this effect.

Design/methodology/approach

Four preregistered correlational/experimental studies (n= 1,763) are used. A pilot study (n= 436) examines the correlations between SMU, FoMO and minimalism. Studies 1 (n= 409), 2 (n= 415) and 3 (n= 503) further investigate the influence of SMU on minimalist consumption intentions, including mindful purchase, forgoing free products and decluttering, and test for evidence of mediation via FoMO by measuring or manipulating FoMO.

Findings

The results show that a high SMU makes consumers susceptible to FoMO, leading to impulsive purchases and careless product acquisition. However, when campaigners promote minimalism as a social media movement, they can activate FoMO, persuading consumers to practice decluttering.

Research limitations/implications

Future research might examine how subjective age affects FoMO and minimalist consumption tendencies. Could campaigners use young social cues to make older consumers more susceptible to FoMO appeals? Could old social cues cause younger consumers to perceive greater social responsibility and to embrace minimalist consumption?

Practical implications

Minimalist lifestyles can promote sustainable consumption. This research provides insights into how SMU is a double-edged sword – it can cause FoMO users to disdain minimalism. However, it can promote minimalism if a minimalist campaign is strategically positioned as a social media movement using a FoMO-laden appeal.

Originality/value

Extant consumer behavior research on minimalism has just begun to investigate the antecedents of minimalist consumption. FoMO is conceptually related to minimalism, but the relationship between FoMO and minimalist consumption has not yet been empirically tested. This research fills these gaps by examining SMU and the associated FoMO as antecedents of minimalist consumption. Empirical evidence for the impact of SMU on various minimalist consumption behaviors and the mediating role of FoMO is provided.
How does the heterogeneity of institutional investors influence corporate tax avoidance? The moderating role of family ownership
Authors: Benkraiem Ramzi , Lakhal Faten , Slama Afef
Published: February 2024

Purpose

This study provides new insights into the relationship between the heterogeneity of institutional investors (IIs) and corporate tax avoidance (CTA). It also investigates whether family ownership moderates this relationship.

Design/methodology/approach

Based on a sample of 200 French-listed firms from 2008 to 2017, we use the generalized method of moment (GMM) estimator proposed by Arellano and Bover (1995) and developed by Blundell and Bond (1998) to address endogeneity and omitted variable concerns.

Findings

The results show that passive IIs are associated with an increase in the level of tax avoidance. However, active ones significantly decrease the levels of tax avoidance practices. Moreover, we show that institutional activism is not sufficient to control managerial actions, particularly in the context of controlled family businesses. The results suggest that families may expropriate the rights of minority shareholders through a controlling coalition with passive IIs.

Research limitations/implications

This study has several practical implications. First, the results are useful for policymakers who should constrain passive IIs to provide only one service (asset management). Second, this study may sensitize family owners to the need to cooperate with active IIs that are effective in monitoring the firm. In particular, families should be willing to sacrifice some of their socioemotional wealth to promote a balanced ownership structure, which is important for responsible and effective corporate governance.

Originality/value

This paper extends previous research by investigating the heterogeneity of IIs in terms of horizon, ownership and control. In addition, this paper sheds a new light on how family firms behave regarding tax avoidance practices in the presence of active and passive IIs.
Hold my beer! Consumer perceptions of innovative and sustainable secondary packaging
Authors: Norris Cortney L. , Orlowski Marissa , Taylor, Jr. Scott
Published: February 2024

Purpose

As a result of both shifting social concerns and stricter legislation, many companies are seeking innovative and sustainable solutions for both primary and secondary packaging. The craft beer industry has made the most notable advancements with a variety of alternatives to the traditional secondary packaging (e.g. plastic rings) used to link beer cans. Yet, despite the impact packaging has on consumer purchase behavior and the environment, secondary packaging has received far less attention in the literature. This study aims to understand consumer perceptions of craft beer secondary packaging on consumers’ willingness to buy via the underlying mechanisms of perceived packaging innovation and sustainability.

Design/methodology/approach

A single-factor between-subjects experiment with four conditions (secondary packaging format: Pak-Tech holder, Keel Clip holder, Glue-Pack holder, Biodegradable holder) was conducted with 354 participants to test the hypothesized serial mediation model.

Findings

The results demonstrate that none of the secondary packaging styles had a direct effect on willingness to buy, meaning that the package style alone does not influence a consumer’s purchase decisions. Critically, the results also revealed indirect effects; specifically, the Keel Clip and Glue-Pack six-pack can holders were perceived as more innovative than the Pak-Tech holder, which in turn positively influenced perceptions of packaging sustainability and subsequent willingness to buy.

Originality/value

The authors’ results extend the research on sustainable secondary packaging and aids craft breweries along with other beverage producers in making informed decisions as the push for sustainable packaging becomes more prominent.
Global fertilizer crisis and willingness to pay for chemical fertilizers: empirical evidence from Nepal
Authors: Thapa Ganesh , Gaihre Yam Kanta , Choudhary Dyutiman
Published: February 2024

Purpose

The purpose of the study is to estimate the willingness to pay (WTP) for major chemical fertilizers and revisit the fertilizer subsidy policy in Nepal.

Design/methodology/approach

We surveyed 619 households from six districts and assessed farmers’ WTP for urea, diammonium phosphate (DAP) and muriate of potash (MOP) during the fertilizer crisis. Our study elicited the WTP for fertilizers when fertilizers were not available on the market. A modified payment card approach was used to elicit farmers’ WTP.

Findings

The study found that farmers who buy fertilizer from agrodealers, buy from gray markets, have bank accounts, are willing to take a risk, have strong or medium economic conditions and incur higher travel costs have a higher WTP for fertilizers. Farmers in sampled areas, on average, are willing to pay 31 percent more for urea, 13 percent more for DAP and 19 percent more for MOP than the government recommended fertilizer price.

Research limitations/implications

The design of the payment card and the estimation techniques used to fit the valuation function are likely to influence WTP.

Originality/value

Overall, literature on households’ WTP for fertilizers in developing countries is scarce. Our study contributes to the knowledge of WTP for fertilizers.
Consumer attitude toward using artificial intelligence (AI) devices in hospitality services
Authors: Bhuiyan Kamrul Hasan , Ahmed Selim , Jahan Israt
Published: February 2024

Purpose

The study investigates the consumer’s attitude to using artificial intelligence (AI) devices in hospitality service settings considering social influence, hedonic motivation, anthropomorphism, effort expectancy, performance expectancy and emotions.

Design/methodology/approach

This study employed a quantitative methodology to collect data from Bangladeshi consumers who utilized AI-enabled technologies in the hospitality sector. A total of 343 data were collected using a purposive sampling method. The SmartPLS 4.0 software was used to determine the constructs' internal consistency, reliability and validity. This study also applied the partial least squares structural equation modeling (PLS-SEM) to test the research model and hypotheses.

Findings

The finding shows that consumer attitude toward AI is influenced by social influence, hedonic motivation, anthropomorphism, performance and effort expectancy and emotions. Specifically, hedonic motivation, social influence and anthropomorphism affect performance and effort expectations, affecting consumer emotion. Moreover, emotions ultimately influenced the perceptions of hotel customers' willingness to use AI devices.

Practical implications

This study provides a practical understanding of issues when adopting more stringent AI-enabled devices in the hospitality sector. Managers, practitioners and decision-makers will get helpful information discussed in this article.

Originality/value

This study investigates the perceptions of guests' attitudes toward the use of AI devices in hospitality services. This study emphasizes the cultural context of the hospitality industry in Bangladesh, but its findings may be reflected in other areas and regions.
Waqif preference of waqf-based qardhul hassan financing in Malaysia using a maqāṣid approach
Authors: Amin Hanudin , Panggi Faizah , Shaikh Imran Mehboob , Abduh Muhamad
Published: February 2024

Purpose

The purpose of this study is to develop a new framework to measure waqif preference of waqf-based qardhul hassan financing in Malaysia.

Design/methodology/approach

Using a maqāṣid approach, this study’s data were drawn from 286 valid usable questionnaires to examine the effects of consumer, family, ummah and humanity factors on the preference.

Findings

The study found that the said factors sourced from Attia’s maqāṣid al-Shariah were instrumental in determining waqif preference to donate in waqf-based qardhul hassan financing.

Research limitations/implications

Like others, this study’s findings are limited in terms of their generalisations and applications. The theory, context and variables used should be expanded in future works.

Practical implications

The results obtained are useful as a yardstick to enable the offered waqf-based qardhul hassan financing for improved mutual well-being among different classes of the wealth of societal groups in Malaysia. Furthermore, the results provide valuable insights into the direction for practitioners mainly managers involved in introducing waqf-based qardhul hassan financing as a new Islamic social financial instrument for poor and needy folks, at best.

Originality/value

This study is novel in terms of the proposed conceptual framework, where the waqif perspective comes into play.
Entrepreneurial orientation and Palestinian family-owned businesses: does governance or geographic location make a difference?
Authors: Sultan Suhail , Hudson Monika , Habash Nojoud , Sultan Wasim I.M. , Izhiman Naser
Published: February 2024

Purpose

This article explores the effect of entrepreneurial orientation (EO), governance and geographic location on the performance of Palestinian family-owned businesses.

Design/methodology/approach

This quantitative study uses data collected in the fall of 2022 from 180 Palestinian-owned family companies – 90 were located in Palestine and the other 90 were located in the USA. Using R software, multiple regression analysis was employed to examine the relationships between the constructs that formed the study's conceptual framework.

Findings

The results indicate that (1) the risk-taking, innovation and proactiveness dimensions of EO have a significant positive impact on the performance of Palestinian family-owned businesses; (2) Governance moderates the EO dimensions of risk-taking and proactiveness on the performance of Palestinian family-owned companies and (3) geographic location does not moderate the relationship between the EO and performance of Palestinian-owned family businesses.

Originality/value

The current intensified conflict in Palestine warrants exploring the role Palestinian family-owned businesses worldwide can play in rebuilding the local economies of Gaza and the West Bank. The following years will be crucial in determining how proactive risk-taking and innovation will support regional recovery and augment the entrepreneurial and reinvestment capacity of diasporic and home country-based Palestinian family-owned firms. Thus, our study into factors that might enhance these businesses' performance and growth potential is pertinent. A further contribution of this study is new insight into the particularities of Palestinian family-owned businesses, augmenting general theories associated with ethnic and diasporic entrepreneurship.
Investigation of the effects of self-crosslinking acrylate with TiO2 nanoparticles on cotton denim fabrics
Authors: Sezgin Bozok Sabiha
Published: February 2024

Purpose

Titanium(IV) oxide nanoparticles (TiO2 NP) were deposited to cotton denim fabrics using a self-crosslinking acrylate – a polymer dispersion to extend the lifetime of the products. This study aims to determine the optimum conditions to increase abrasion resistance, to provide self-cleaning properties of denim fabrics and to examine the effects of these applications on other physical properties.

Design/methodology/approach

The denim samples were first treated with nonionic surfactant to increase their wettability. Three different amounts of the polymer dispersion and two different pH levels were selected for the experimental design. The finishing process was applied to the fabrics with pad-dry-cure method.

Findings

The presence of the coatings and the adhesion of TiO2 NPs to the surfaces were confirmed by scanning electron microscope and Fourier transform infrared spectroscopy analysis. It was ascertained that the most appropriate self-crosslinking acrylate amount and ambient pH level is 10 mL and “2”, respectively, for providing increased abrasion resistance (2,78%) and enhanced self-cleaning properties (363,4%) in the denim samples. The coating reduced the air permeability and softness of the denim samples. Differential scanning calorimetry and thermogravimetry analysis results showed that the treatments increased the crystallization temperatures and melting enthalpy values of the denim samples. Based on the thermal test results, it is clear that mass loss of the denim samples at 370°C decreased as the amount of self-crosslinking acrylate increased (at pH 3).

Originality/value

This study helped us to find out optimum amount of self-crosslinking acrylate and proper pH level for enhanced self-cleaning and abrasion strength on denim fabrics. With this finishing process, an environmentally friendly and long-life denim fabric was designed.
Commentary on “Implementation of an adapted handwriting without Tears® programme for children with developmental disabilities in a special education setting”
Authors: Vascelli Luca
Published: February 2024

Purpose

This paper aims to serve as a commentary on the paper titled “Implementation of an Adapted Handwriting Without Tears® Programme for Children with Developmental Disabilities in a Special Education Setting.”

Design/methodology/approach

It provides an overview of educational strategies that can be used in school settings to support professionals in acquiring skills relevant to their practice and promoting the acquisition of new abilities for their students.

Findings

It explores three critical aspects of education: measuring academic progress, using evidence-based methods and enhancing educator training.

Originality/value

This work represents the personal perspective of a professional working in the service delivery field for children with developmental disabilities in schools and rehabilitative centres.
For every action a reaction? The polarizing effects of women's rights and refugee immigration: A survey experiment in 27 EU member states
Authors: ALEXANDER AMY , CHARRON NICHOLAS , OFF GEFJON
Published: February 2024

Building on research on cultural threat‐induced polarization, we investigate the effect of the individual‐level salience of cultural threats on polarization between social liberals and conservatives. In a unique survey experiment conducted with 129,000 respondents nested in 208 regions in 27 European Union (EU) member states, we manipulate the presence of two cultural threats, women's rights, and refugee immigration, to test their polarizing effects on social liberals’ and social conservatives’ support for traditional values. We find that priming the threat of refugee immigration polarizes conservatives and liberals equally. Yet, introducing the salience of women's rights leads to lower preferences for traditional values, particularly among more liberal respondents. Our findings demonstrate: 1) the study of backlash should distinguish individuals by their predisposition to backlash, rather than studying the population as a whole; and 2) social conservatives’ backlash should be studied conjointly with social liberals’ counter‐reactions to backlash. Future research may investigate why different cultural threats provoke different reactions.
End‐of‐life decision‐making in the emergency department and intensive care unit: Health professionals' perspectives on and knowledge of the law in Queensland
Authors: Hewitt Jayne , Alsaba Nemat , May Katya , Kang Evelyn , Cartwright Colleen , Willmott Lindy , White Ben , Marshall Andrea P
Published: February 2024

Objective

To investigate ED and intensive care unit healthcare professionals' perspectives and knowledge of the law that underpins end‐of‐life decision‐making in Queensland, Australia.

Methods

An online survey with questions about perspectives, perceived, and actual, knowledge of the law was distributed by the professional organisations of medical practitioners, nurses and social workers who work in Queensland EDs and intensive care units.

Results

The survey responses of 126 healthcare professionals were included in the final analysis. Most respondents agreed that the law was relevant to end‐of‐life decision‐making, but that clinician and family consensus mattered more than following the law. Generally, doctors' legal knowledge was higher than nurses'; however, there were significant gaps in the knowledge of all respondents about the operation of advance health directives in Queensland.

Conclusions

The legal framework that supports end‐of‐life decision‐making for adults who lack decision‐making capacity has been in place for more than two decades. Despite frequently being involved in making or enacting these decisions, gaps in the legal knowledge of healthcare professionals who work in EDs and intensive care units in Queensland are evident. Further research to better understand how to improve knowledge and application of the law is warranted.