bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUKASI KESEHATAN KEUANGAN RUMAH TANGGA MUSLIM MILENIAL
Authors: Nihayah Ana Zahrotun , Chamami M Rikza , Rifqi Lathif Hanafir
Published: February 2024

Rumah tangga muslim milenial memiliki berbagai persoalan rumah tangga diantaranya adalah masalah keuangan. Persoalan ini dikarenakan pemikiran pasangan rumah tangga muda belum pada tingkat yang matang. Pelaksanaan pengabdian kepada masayarakat menggunakan metode service learning. Kegitan dibagi dalam tiga tahapan yaitu persipan, layanan dan refleksi. Tahapan persiapan diurai dalam empat aktivitas yaitu penetapan jadwal, pembuatan materi, publikasi peserta, dan pembuatan rundown penyuluhan. Tahapan layanan memaparkan dua materi besar yaitu penyebab kesehatan fakror-faktor yang mengganggu persoaalan kesehatan keuangan rumah tangga serta indikator kesehatan keuangan rumah tangga. Ada lima hal yang menyebabkan kesehatan keuangan rumah tangga bermasalah yaitu 1) perbedaan gaya hidup (perilaku konsumsi); 2) ketimpangan penghasilan; 3) kepemilikan pinjaman tersembunyi, 4) tidak memiliki perencanaan keuangan, 5) kepemilikan tabungan rahasia. Sementara, terdapat lima indikator kesehatan keuangan rumah tangga yaitu a) kelancaran arus kas periode tertentu, b) besaran kepamilikan tabungan rumah tangga, c) batasan angsuran pinjaman yang diperbolehkan, d) kepemilikan asuransi kesehatan, serta e) kepemilikan investasi. Tahapan refleksi menyampaikan tingkat pemahan peserta atas materi yang sudah disampaikan, 70% peserta merasa sangat paham, 23% peserta merasa paham sedangkan 7% peserta merasa kurang paham.
SEHATI’s Contribution (Free Halal Certification) For Medium and Small Enterprises (MSE) in Indonesia
Authors: Sari Yunita Ratna
Published: February 2024

Introduction: Indonesia has great potential in developing the halal industry sector such as halal food, fashion, cosmetics, pharmaceuticals, tourism, media, financial services which will reach IDR 4,375 trillion so that it can support national economic growth as well as become a role model for the halal industry in Indonesia. But in fact, Indonesia as the largest consumer country of halal food is not the largest producer of halal products. So, that free halal certification is needed so that Indonesia becomes the number 1 exporter of halal products in the world. Research Methods: literature study and then analyzed by analytical descriptive analysis. Results: SEHATI's contribution to UMK in Indonesia, namely 1) accelerating the halal certification procedure, 2) MSEs in managing halal certification are free of charge, 3) the halal certification process can be carried out online using the Sihalal and Pusaka applications to make it easier to take care of halal certification. Conclusion: SEHATI contributed For Medium and Small Enterprises (UMK) in Indonesia, because it could raise the profitability, trust and satisfaction consumers and guaranteed quality of product.
Pengaruh Experiential Marketing dan Emotional Marketing Terhadap Loyalitas Pelanggan dengan Kepuasan Sebagai Variabel Intervening pada Platform E-Commerce Tokopedia
Authors: Aqmarina Fauziah , Awali Husni
Published: February 2024

Introduction: This research aims to analyze the effect of experiential marketing and emotional marketing on the loyalty of generation Z Muslim customers through satisfaction on the Tokopedia e-commerce platform in Bandar District, Batang Regency. Research Methods: The analytical method used in this research is quantitative analysis method. The population in this study is Tokopedia's Muslim e-commerce customers belonging to Generation Z aged 20-24 years in Bandar District. The total population is 6,568 thousand people. Results: The results of this study indicate that experiential marketing and emotional marketing affect the loyalty of generation Z Muslim customers through satisfaction on the Tokopedia e-commerce platform in Bandar District, Batang Regency. Based on the research, it was found that the people of Bandar Sub-district belonging to Generation Z, aged 20-24 years, use Tokopedia continuously because they are influenced by the experiential marketing and emotional marketing strategies carried out by Tokopedia.
Development of Islamic Economy through the Empowerment of Pesantren as Economically Independent Institutions in Indonesia
Authors: Fahmi Reza , Aswirna Prima
Published: February 2024

Introduction/Main Objectives: this study wants to illustrate: (1). Analyze the development of agricultural, plantation, fishery businesses managed by Islamic boarding schools. (2) Analyze obstacles and opportunities for entrepreneurial business development developed in pesantren. (3) Analyze possible solutions developed to improve the quality of entrepreneurship that has been developed by pesantren. Research Methods: This research uses a qualitative approach. In-depth interviews and observations as data collection methods. Data analysis uses the approach used by miles and hubermen. Results: The results of this study found that; First, the development of agricultural, plantation and fishery businesses in Islamic boarding schools is still very conventional. Second, the challenge that arises is to expand the market network to market business products. Third, "Marrying" agricultural business activities that have been developed with optimal technological development.  Conclusion: Broading up market with using internet will incease the income  of Islamic Boarding School as Self-fulfillment institution.
The Influence of Capital and Online Marketing Strategies on MSME’s Development in Madiun City
Authors: Putri Sedinadia , Yunita Ratna
Published: February 2024

Introduction: The Micro, Small, and Medium Enterprises Group (UMKM) in Madiun City is a facility for MSME actors with a business license. The goal of this MSME group is for their efforts to achieve maximum development results. However, the MSME group's business in Madiun City still needs to develop. This can be seen from the addition of capital and the use of technology in a marketing strategy that does not make the business being run develop. Based on these problems, this study aims to test and analyze whether capital and online marketing strategies positively affect the development of MSMEs in the MSME Group in Madiun City. Research Methods: The type of research used is quantitative research with a population of 300 and a sample of 75 respondents. This study uses the Probability Sampling technique of Simple Random Sampling and data collection methods using a questionnaire/questionnaire. Statistical data analysis technique using SPSS 16.0. This research uses validity, reliability, descriptive analysis, classical assumption test, t-test, f-test, multiple linear regression, and coefficient of determination. Result: The results of this study indicate that (1) capital has a positive and significant effect on the development of MSMEs in the MSME group in Madiun City, (2) online marketing strategies have a positive and significant effect on the development of MSMEs in the MSME group in Madiun City, (3) capital and strategies Online marketing simultaneously has a positive and significant effect on the development of MSMEs in the MSME group in Madiun City. Conclusion: Based on the results of hypothesis testing, it can be concluded that the capital variable and online marketing strategy simultaneously (together) have a positive and significant effect on the development of MSMEs in the MSME group in Madiun City.
The Effect of the Performance of the Board of Commissioners and Directors on Company Profitability in the 2019-2021 Jakarta Islamic Index (JII) With Salary as a Moderating Variable
Authors: Dwiyanti Susi , Damanuri Aji , Maharani Shinta
Published: February 2024

Introduction: During the pandemic, many companies experienced a decline in profitability. One of them is what happened to companies included in the Jakarta Islamic Index (JII). During the pandemic the performance of the board of commissioners and directors could have been more optimal while the number of salaries for the board of commissioners and directors remained even increased. This can be seen from the profitability of several companies that are members of the Jakarta Islamic Index (JII), which are still below the average standard. The profitability of several companies that are members of the Jakarta Islamic Index (JII) is experiencing an imbalance. This study aims to determine the effect of the board of commissioners and directors on the profitability of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021 and salary as a moderating variable. Research Methods: This study uses a population of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021, using a sample of 54 companies. The type of this research is quantitative research. Meanwhile, data collection techniques use documentation and observation of the annual reports of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021. Data analysis used is moderation regression analysis, classic assumption test, hypothesis testing and coefficient of determination (R2). Result: the results of this study indicate that the boards of commissioner variables affect the profitability of companies that are members of the Jakarta Islamic Index (JII) for 2019- 2021. The Directors influence the profitability of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021. Meanwhile, salaries significantly moderate the influence of the board of commissioners and directors on the profitability of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021. Conclusion: The results of this study indicate that the board of commissioners variables affect the profitability of companies that are members of the Jakarta Islamic Index (JII) for 2019-2021.
Implementation of Problem Based Learning (PBL) Based Conflict Management Through The Syawir Forum at PPTQ Al-Hasan Ponorogo
Authors: Ayu Karisma Linda , Qholik Wisnu , Thoyib Muhammad
Published: February 2024

AbstractPPTQ Al-Hasan Ponorogo, East Java, created syawir forum both as a conflict management activity and santri's learning activity with problem based learning method. This research focused on two things: how to implement conflict management through syawir forum in PPTQ Al-Hasan Ponorogo and learning concept based on the problem related to some programs that were created by syawir forum. This research was conducted using qualitative research method in the form of case study approach through observation, interview, and documentation as the data collection method. This research was also conducted using structured interview technique and snowball sampling to collect the data resources and determine informant resources. The result of this research showed that conflict management could be implemented in  a pesantren through syawir forum and a learning place for santri to comprehend and analyze conflicts in daily life when it comes to society. A conflict management that was implemented could create pesantren programs divided into internal programs and external programs as preventive and solution in pesantren to cope with existing conflicts. AbstrakPondok Pesantren Tachfidzul Qur’an Al-Hasan Ponorogo, Jawa Timur, menjadikan forum syawir sebagai wadah kegiatan manajemen konflik sekaligus kegiatan pembelajaran bagi santri dengan metode problem based learning. Penelitian ini berfokus pada dua hal; bagaimana pelaksanaan manajemen konflik melalui forum syawir di Pondok Pesantren al-Hasan Ponorogo dan konsep pembelajaran berbasis masalah dengan program-program yang dihasilkan pada forum syawir. Penelitian ini dilakukan dengan metode penelitian kualitatif berupa pendekatan studi kasus dengan metode pengumpulan data melalui observasi, wawancara dan dokumentasi. Penelitian menggunakan teknik wawancara terstruktur dan snowball sampling dalam menggali sumber data dan menentukan sumber informan. Hasil penelitian yang diperoleh menunjukkan manajemen konflik dapat dilakukan dalam sebuah pesantren melalui forum syawir sekaligus dapat menjadi wadah pembelajaran bagi santri untuk memahami dan menganalisis konflik di kehidupan nyata saat terjun di masyarakat. Manajemen konflik yang dilakukan menghasilkan program-program pesantren yang dibagi menjadi program internal dan program eksternal sebagai upaya preventif dan solutif pesantren dalam menghadapi adanya konflik.
Hadith Interpretation of Law and Justice and Its Implementation as an Alternative Solution Rule of Law Enforcement In Indonesian
Authors: Rahman Rahman , Sugianto Efendi , Wasalmi Wasalmi , Asriady Muhammad , Fauzi Ahmad
Published: February 2024

AbstractThis article wants to explain the interpretation of hadith on law and justice and its implementation as an alternative solution to upholding the supremacy of law in Indonesia. This aims to address the social gap in law enforcement in Indonesia which is characterized by the increasing number of law violations due to a lack of firmness in law enforcement itself. This research is library research, namely library research, because all primary data is written data, especially those related to the Prophet's hadith about law and justice and their interpretation in the context of upholding the supremacy of law in Indonesia. The main sources are hadith books which are also featured in other cases relevant to the research. The results of this research indicate that the Prophet's hadith regarding law and justice can be implemented in the context of law enforcement in Indonesia because law enforcement during the time of the Prophet as described in the Prophet's hadith contained the principles of justice in society. When a crime is committed by a lawbreaker, the law can treat it as fairly as possible. AbstrakArtikel ini ingin menjelaskan tafsir hadis hukum dan keadilan serta implementasinya sebagai alternatif solusi tegaknya supremasi hukum di Indonesia. Hal ini bertujuan untuk menjawab kesenjangan sosial dalam penegakan hukum di Indonesia yang ditandai dengan semakin banyaknya pelanggaran hukum akibat kurangnya ketegasan dalam penegakan hukum itu sendiri. Penelitian ini merupakan penelitian kepustakaan yaitu penelitian kepustakaan, karena seluruh data primernya merupakan data tertulis, khususnya yang berkaitan dengan hadis Nabi tentang hukum dan keadilan serta penafsirannya dalam rangka penegakan supremasi hukum di Indonesia. Sumber utamanya adalah kitab-kitab hadis yang juga ditampilkan dalam kasus-kasus lain yang relevan dengan penelitian. Hasil penelitian ini menunjukkan bahwa hadis Nabi tentang hukum dan keadilan dapat diimplementasikan dalam konteks penegakan hukum di Indonesia karena penegakan hukum pada masa Nabi yang telah dijelaskan dalam hadis Nabi mengandung prinsip-prinsip keadilan di tengah-tengah masyarakat. ketika suatu kejahatan terjadi dilakukan oleh pelanggar hukum, maka hukum itu dapat memperlakukan dengan seadil-adilnya
Design-Develop-Decide: A Framework for User and Implementation Evaluation in Digital Health.
Authors: Gough Philip , Shetty Amith , Wang Audrey P
Published: February 2024

Purpose: This paper introduces the Design-Develop-Decide (3D) framework, addressing the transdisciplinary research gap in the convergence of design think-ing and implementation, particularly in early-stage translation research for health settings. Focused on clinical decision support tools using artificial intel-ligence (AI), the framework emphasizes factors like clinical utility, safety, and human-computer interaction, with a specific focus on in-hospital implementation.
Methods: The case study focuses on a clinical AI in-hospital tool for sepsis risk assessment, utilising near real-time data. Employing iterative design evalu-ations and integrating user-design with early implementation science evaluation, the research enhances the usability of digital health tools, specifically in an emer-gency waiting room context. Evaluation methods include in-hospital observations, surveys, Think Aloud usability testing, and various questionnaires.
Results: Phase 1 identifies key elements affecting sepsis risk identification, lead-ing to the design goal of supporting clinicians in promptly identifying at-risk patients not assigned to the correct triage category. Phase 2 involves pre-deployment surveys and usability testing, showing improved decision-making in targeted clinical tasks related to sepsis risk assessment. Phase 3 reveals clini-cians’ preferences for integrating the sepsis dashboard into existing workflows, with clinician engagement and understanding through interaction.
Conclusion: We advocate for the 3D framework’s integration of formative interaction design methodologies and implementation science, offering practi-cal guidance for early-stage digital health technology adoption. Reflections on strengths and limitations of the approach are provided, highlighting the frame-work’s adaptability beyond clinical decision support tools to other digital systems in the digital health domain.
Impacts of organic and conventional management systems on weeds and insects’ biodiversity
Authors: Rad Mansoure Mahlouji , Moghaddam Parviz Rezvani , Asadi Ghorbanali , Lashkari Azam
Published: February 2024

Global farming systems aim to improve productivity while minimizing its negative environmental consequences. Organic farming is one of the solutions for reducing the negative impact of global warming which requires a comprehensive assessment as the extent of its benefits and impacts is largely uncertain in different regions of the world. Thus, this study was done to assess weeds and insects' diversity under organic and conventional farming systems of wheat and potato in a semi-arid region. The experiments were conducted on two certified organic wheat and potato fields and two conventional wheat and potato fields in northeast of Iran during 2011–2013. Insects and weeds sampling were carried out for several times during the growing season. Shannon-Wiener and Simpson's indices calculated for different sampling stages. The results illustrated that species richness and biodiversity indexes of insects in organic wheat fields was higher than the conventional fields. The number of harmful (pest) families in conventional fields was higher than organic fields. The organic potato field had a higher Shannon index for weed communities during the first and second year of the experiment than the conventional one. The reported organic yields were higher than conventional management mainly due to the application of high yielding varieties in organic fields. In summary, our results show that there is a great potential for transformation from conventional to organic farming particularly for wheat production.
Removal of Calcium and Magnesium Ions from Reverse Osmosis Concentrate Using a Two-stage Precipitation with Carbonation Process
Authors: Liu Yucheng , Zhu Mengke , Ji Xinghu , Tan Zhiyou , He Zhike
Published: February 2024

The reverse osmosis (RO) technique has been extensively employed in the advanced treatment of industrial water and wastewater. However, this process results in the production of a significant quantity of reverse osmosis concentrate (ROC), which contains high levels of salinity and organic contaminants, thereby posing serious environmental problems. This study reported a two-stage precipitation process utilizing quicklime (CaO) and caustic soda (NaOH) in conjunction with air blowing (carbonation) for the removal of Ca2+ and Mg2+ from real brackish water ROC of factory. In stage I, the CaO precipitation-carbonation process was employed to eliminate the majority of Ca2+ from the ROC, while leaving Mg2+ virtually unaffected, yielding high-purity CaCO3 precipitates. In stage II, the NaOH precipitation method was utilized to eliminate the remaining Ca2+ and Mg2+ from the ROC. It was demonstrated that under optimal conditions, the removal rates of Ca2+ and Mg2+ exceeded 97%. Finally, the characterization of precipitates demonstrated the generation of high-purity CaCO3 precipitates in stage I, as well as the formation of CaCO3 and Mg(OH)2 precipitates in stage II. The results confirmed the feasibility of employing the two-stage precipitation with carbonation process to economically treat ROC and enable its reuse, offering valuable insights for the treatment of industrial wastewater.
A novel organic-inorganic matrix nanofiltration membrane for remediating copper with enhanced thermal stability and mechanical strength
Authors: Kirubanandam Sangeetha , Sriniva Latha , Alshalwi Matar , Rajamanickam Ashok Kumar , Narayanan Sudha Parappurath
Published: February 2024

Membrane separation technology in the last forty years had an impressive growth, displacing conventional separation processes due to inherent advantages such as less capital investment, energy efficient and the devices were simple, compact and modular. In the current work, we aimed to synthesize a thin sheet nanofiltration membrane using chitosan, poly(vinyl) alcohol and montmorillonite clay for copper removal from aqueous solution. As prepared novel organic-inorganic hybrid membrane is characterized with analytical techniques such as Thermogravimetric analysis and Differential scanning calorimeter to evaluate its thermal stability. Tensile strength was measured to evaluate its stability over a wide range of temperature and pressure. The surface and cross-section morphology of membrane were studied using Scanning electron microscopy. Finally, the as prepared membrane was employed for filtration performance by adjusting parameters such as pH, metal ion concentration, pressure and membrane thickness. The remediation of copper with this innovative membrane was validated by comparing spectral images, such as EDAX and FT-IR taken both before and after filtration and a mechanism was proposed to explain the hooking of copper ions with the as prepared membrane.
A meta-analysis of cumulative incidence of hepatocellular carcinoma after the Fontan operation
Authors: Hansen Sophie , Gilroy Richard , Lindsay Ian , Doty John R. , Butschek Ross A. , Danford Christopher J.
Published: February 2024

Background
Hepatic complications are increasingly recognized after the Fontan operation. The development of hepatocellular carcinoma (HCC) is associated with high mortality when diagnosed, but its incidence and risk factors are poorly understood. We conducted a systematic review and meta-analysis of the cumulative incidence of HCC after Fontan and associated risk factors.
Methods
We searched PubMed, CINAHL, and MEDLINE databases for articles reporting the cumulative incidence of HCC after Fontan operation on March 21, 2023. A single-arm random effects meta-analysis was conducted to assess cumulative incidence at 10-, 20-, and 30-years after Fontan. Meta-analysis of the difference of the medians was used to assess the influence of risk factors on the development of HCC.
Results
Four studies including a total of 1,320 patients reported cumulative incidence. The cumulative incidence of HCC at 10-, 20-, and 30-years after Fontan was 0% (95% CI 0.00-0.01), 2% (0.01–0.06), and 7% (0.03–0.17) respectively. Seven studies including 6,250 patients reported overall incidence of HCC and associated risk factors. At a median 18.4 (IQR 11.9–24.9) years of follow-up, incidence of HCC was 2% (0.01–0.04). Only use of anticoagulation was associated with a lower risk of HCC (RR 0.3, 95% CI 0.1–0.88).
Discussion
By 30 years after Fontan, cumulative incidence of HCC is high (7%). Risk of HCC development prior to 10-years post-Fontan is low (0%) and HCC screening can be safely deferred in this population. Screening with ultrasound every 6 months starting 20-years post-Fontan is reasonable, however, further research regarding timing, cost-effectiveness, additional risk factors associated with HCC risk, and different screening modalities is required.
WITHDRAWN: Leveraging Leaf Spectroscopy to Identify Drought-Resistant Soybean Cultivars
Authors: de Paula¹ Ramon Goncalves , Silva Martha Freire , Amaral Cibele , Paula Guilherme Sousa , Silva Laércio Junio , Pessoa Herika Paula , Silva Felipe Lopes
Published: February 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Assessment and monitoring of the Dead Sea surface area and water level using remote sensing and GIS techniques
Authors: Farhan Ibrahim , Mahafdah Mohmmad , Sathiamurthy Edlic , Salameh Lina , Albahrat Fesail
Published: February 2024

Situated at Earth's lowest continental point, the Dead Sea experiences a worrying decline in water levels. The primary drivers include the diversion of water from the Jordan River and its tributaries, as well as mineral extraction activities on both sides of the lake. The aim of this study is to analyze the thematic map of 1971 and satellite images of 1984, 1994, 2004, 2014 and 2022 of the Dead Sea to determine the surface area and water level of the Dead Sea and its declining rate. CA-Markov model were employed to generate projected surface area of Dead Sea for periods 2034 and 2050. Time series of observed and future using RPC’s 4.5 and 8.5 of climate data especially temperature were analysis has been implemented to track the climate behavior. Statistical analyses of Kendall correlation matrix were performed on observed and predicted of surface area, water level and temperature. The study shows that the Dead Sea has shrunk by 41.8% during the period from 1971 to 2022, while the water sea level is expected to decrease 12.63 m and 33 m for period 2034 and 2050 respectively. In addition, there were a significant inverse relationship between surface area, water level and temperature with correlation (r=-0.79; p = 0.001) and (r=-0.82; p = 0.001), respectively. It is worth highlighting that from 2022 to 2050, the mean annual temperature is expected to rise by at least 1 ˚C. The long-term strategic vision for stabilizing Dead Sea water levels envisions a two-fold approach: (1) augmenting natural inflow through the introduction of 300–400 million MCM from manufactured sources channeled into the Jordan River, and (2) implementing a reduction in water extraction by Dead Sea industries up to a maximum of 330 million MCM.
Construction of a novel five-dimensional Hamiltonian conservative hyperchaotic system and its application in image encryption
Authors: yan Minxiu , Li Shuyan
Published: February 2024

In order to investigate the potential application of conservative hyperchaotic systems in secure communication and image encryption, a novel five-dimensional
Hamiltonian conservative hyperchaotic system was developed based on the Euler equation theory. Subsequently, the system’s dynamic behaviors, including
Hamiltonian energy conservation, phase volume conservation, and symmetrical Lyapunov exponent about 0, were analyzed through energy analysis, dynamic
analysis, and numerical simulation. The results revealed that the new system exhibits strong conservative hyperchaotic characteristics within a wide range
of initial values and parameters, with a remarkable increase in the maximum Lyapunov exponent. This enhanced chaotic behavior makes the new system
more suitable for image encryption applications. Furthermore, by altering the initial value, a nested coexistence phenomenon of multiple energy levels was
observed. Finally, the system was successfully applied to image encryption, and an image encryption algorithm was designed and validated to possess superior
confidentiality performance.
Chemical Distinctions of Groundwater Consumed by Communities Affected by Chronic Kidney Disease of Unknown Etiology in Northcentral Sri Lanka: Implications for Multiple Contributory and Inhibitory Ions
Authors: Prame Bernard , Siriwardana Shamalie , Hettiarachchi Sanjeewa , Jayalath Priyanka , Wanasinghe Vindya , Guruge Panduka
Published: February 2024

Long-term exposure to contaminated drinking water from shallow dug wells is widely suspected to be the cause of chronic kidney disease of unknown etiology (CKDu) which prevails in northcentral Sri Lanka. Although several hydrogeochemical studies have been conducted in this area, studies that have attempted robust statistical comparisons between waters consumed by CKDu-affected and CKDu-free communities within the endemic area are rare, and the causative agents of the disease remain elusive. We attempted to determine the hydrochemical differences between the groundwater consumed by CKDu-affected communities and that consumed by CKDu-unaffected communities living in the CKDu-endemic area based on a substantial new dataset that ensures the robustness of the statistical and graphical comparisons. The study revealed that SO42−, PO43−, NO3−, Sr, Mg, Ba, Pb, and Cu were significantly greater in CKDu-linked water and were positively correlated with the incidence of CKDu, indicating their causative role. Manganese and Zn levels were significantly lower in CKDu-linked water and were negatively correlated with CKDu-incidence, indicating an impeding effect. Our results agree with the elevated hardness and F− values reported in previous work. However, statistical and graphical comparisons do not support the widely speculated role of F− in the incidence of CKDu. Toxic metals and metalloids except for V occur at concentrations accepted as safe for human consumption. Subtle but significant contributions from several chemical constituents occurring in concentrations accepted to be safe and permissible could be interpreted as supporting evidence for the participatory role of multiple ions, probably imposing a deleterious synergistic effect.
Shared whole environmental etiology between Alzheimer's disease and Age-related macular degeneration
Authors: Zhang Xueli , Ye Siting , Ma Shuo , Liu Shunming , Huang Yu , Li Dantong , Li Min , Su Ting , Luo Jing , Zhang Chi , Shi Danli , Hu Lianting , Zhang Lei , Yu Honghua , He Mingguang , Shang Xianwen
Published: February 2024

The comorbidity of Alzheimer's disease (AD) and age-related macular degeneration (AMD) has been established in clinical and genetic studies. There is growing interest in determining the shared environmental factors associated with both conditions. Recent advancements in record linkage techniques enable us to identify the contributing factors to AD and AMD from a wide range of variables. As such, we firstly constructed a knowledge graph based on the literature, which included all statistically significant risk factors for Alzheimer's disease AD and AMD. An Environment-Wide Association Study (EWAS) was conducted to assess the contribution of various environmental factors to the comorbidity of AD and AMD based on the UK biobank. Based on the conditional QQ plots and Bayesian algorithm, several shared environmental factors were identified, which could be categorized into the domains of health condition, biological sample parameters, body index, and attendance availability. Finally, we generated a shared etiology landscape for AD and AMD by combining existing knowledge with our novel findings.
The Impact of Exercise Self-Efficacy on College Students’ Emotion Management ability: An Analysis of the Mediating Effects Based on Exercise Behavior and Screen Media Use
Authors: Zhu Weidong , Liu Jun , Lou Hu , Mu Fanzheng , Li Bo
Published: February 2024

Objective: To explore the impact of exercise self-efficacy on college students’ emotion management ability and to analyze the mediating effects of exercise behavior and screen media use between exercise self-efficacy and emotion management ability.
Methods: This study adopted stratified, whole-cluster, and staged sampling methods, using an online questionnaire that included demographic information, exercise self-efficacy, exercise behavior, screen media use, and other relevant aspects, obtaining a total of 11,227 valid questionnaires.
Results: The study indicated a significant positive correlation between exercise self-efficacy and emotionmanagement ability (r=0.348, P<0.01). There was also a positive correlation between physical exercise and emotion management ability (r=0.136, P<0.01). In contrast, smartphone use showed a significant negative correlation with emotion management ability (r=-0.114, P<0.01). Additionally, exercise persistence and electronic health literacy presented significant positive correlations with emotion management ability (r=0.365, 0.500). Chain mediated effect analysis revealed that exercise self-efficacy positively affected emotion management ability by reducing smartphone use and enhancing exercise persistence (95% CI: [0.001, 0.002]). Furthermore, exercise self-efficacy positively affected emotion management ability by enhancing both exercise persistence and exercise self-efficacy (95% CI: [0.028, 0.042]). These two chain mediators revealed the pathways through which they affect emotion management ability.
Conclusion: This study deepened the understanding of the interplay between exercise behavior, screen media use, and emotion management ability. It suggested that emotion management ability could be enhanced through strategies of improving exercise persistence, physical exercise, electronic health literacy, and reducing smartphone use, while considering differences in gender and academic year in intervention programs.
Relationship between Nursing Practice Environment and Psychological Empowerment for Nurses: A Cross-Sectional Study
Authors: Taketomi Kikuko , Ogata Yasuko , Sasaki Miki , Yonekura Yuki , Tanaka Michiko
Published: February 2024

The nursing practice environment is essential for improving the quality of nursing practice and patient service. This study investigated whether a better, healthier work environment could enhance nurses’ psychological empowerment using data from the work environment for hospital nurses in Japan (WENS-J) study. A total of 7,849 staff nurses from 23 participating general hospitals with over 200 beds in municipalities with a population of 200,000 or more were sent a self-administered questionnaire in 2014. The questionnaire recorded participating nurses’ demographic characteristics and utilized two scales: the Practice Environment Scale of the Nursing Work Index (PES-NWI) and the Psychological Empowerment Instrument (PEI), which identified adequate work environments and measured the internalization of organizational goals and objectives, respectively. The valid response rate was 31.1% (n = 2,438), the mean age was 33.7 years, and 93.7% of nurses were female. The total PEI score was significantly correlated to the PES-NWI composite score and all subscales after adjusting for nurses’ demographic characteristics, such as age (β coefficient 0.22–0.33, all p < .001). Nurses who perceive their work environment as positive may be more psychologically empowered. These findings could provide insight into creating healthier work environments; previous studies have shown that psychological empowerment is related to reduced burnout and low turnover among nurses.
Evaluation of transfer ensemble learning-based convolutional neural network models for the identification of chronic gingivitis from oral photographs
Authors: Li Wen , Guo Enting , Zhao Hong , Li Yuyang , Miao Leiying , Liu Chao , Sun Weibin
Published: February 2024

Background
To evaluate the performances of several advanced deep convolutional neural network models (AlexNet, VGG, GoogLeNet, ResNet) based on ensemble learning for recognizing chronic gingivitis from screening oral images.
Methods
A total of 683 intraoral clinical images acquired from 134 volunteers were used to construct the database and evaluate the models. Four deep ConvNet models were developed using ensemble learning and outperformed a single model. The performances of the different models were evaluated by comparing the accuracy and sensitivity for recognizing the existence of gingivitis from intraoral images.
Results
The ResNet model achieved an area under the curve (AUC) value of 97%, while the AUC values for the GoogLeNet, AlexNet, and VGG models were 94%, 92%, and 89%, respectively. Although the ResNet and GoogLeNet models performed best in classifying gingivitis from images, the sensitivity outcomes were not significantly different among the ResNet, GoogLeNet, and Alexnet models (p>0.05). However, the sensitivity of the VGGNet model differed significantly from those of the other models (p < 0.001).
Conclusion
The ResNet and GoogLeNet models show promise for identifying chronic gingivitis from images. These models can help doctors diagnose periodontal diseases efficiently or based on self-examination of the oral cavity by patients.
Femoral bone metastasis is a poor prognostic factor in osimertinib-treated patients with EGFR-mutated non-small cell lung cancer: a retrospective, multicenter study
Authors: Tanaka Ichidai , Gen Soei , Hori Kazumi , Morise Masahiro , Koyama Junji , Kodama Yuta , Matsui Akira , Miyazawa Ayako , Hase Tetsunari , Hibino Yoshitaka , Yokoyama Toshihiko , Kimura Tomoki , Yoshida Norio , Sato Mitsuo , Ishii Makoto
Published: February 2024

Background:
Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) have higher frequency of bone metastases than those of wild type; however, the metastatic pattern and the influence on clinical outcome remains unclear. Therefore, we retrospectively analyzed the association between bone metastatic sites and the clinical efficacy of the third-generation EGFR-tyrosine kinase inhibitor (TKI), osimertinib, in these patients.
Methods:
Clinical data of patients with advanced-NSCLC harboring EGFR mutation (N=411) at five medical institutions were retrospectively assessed for bone metastatic sites, overall survival (OS) and progression-free survival (PFS).
Results:
Bone metastases was found in 41.1% of the patients at diagnosis, including 13.1% for single lesion, 8.0% for double lesions, and 20.0% for multiple lesions (≥3). Among them, vertebra (76.3%) and pelvis (60.9%) were most frequent metastatic sites. Femoral-, sternum-, and scapula-metastases were remarkably increased in the patients with multiple-bone metastasis. In the common EGFR-mutant NSCLC patient treated with osimertinib, both the OS and the PFS of the patients with femoral bone metastasis were remarkable significant shorter than those of the patients without femoral bone metastasis (OS; not reached vs. 12.1 months, P< 0.0001, and PFS; 17.2 vs. 9.3 months, P < 0.0018). Furthermore, a multivariable cox regression analysis, including several poor prognostic factors such as L858R mutation and liver metastasis, demonstrated that femoral bone metastasis was a statistically independent predictor of OS.
Conclusion:
Femoral bone metastasis is notably associate with poor survival of EGFR-mutant NSCLC patients who were treated with osimertinib, and is an independent prognostic factor of OS.
Comprehensive Bioinformatic Analysis for Identification of Crucial Genes and Signaling Transduction Pathways in Head and Neck Squamous Cell Carcinoma
Authors: Cheon Jaehwan , Kim Byoungjae , Byun Junhyoung , Jung Semyung , Kim Jaehyeong , Kwak Sooun , Shin Jaemin , Kim Tae Hoon
Published: February 2024

Head and neck squamous cell carcinoma (HNSCC) is a prevalent global cancer, ranking sixth in incidence. Investigating the molecular basis of tumorigenesis and metastasis is crucial for early detection and effective treatment. Our study utilized three gene expression profile datasets (GSE6791, GSE29330, and GSE58911) to identify co-up or down-regulated differentially expressed genes (DEGs) between HNSCC tumor and normal tissue samples, associated primarily with processes like extracellular matrix (ECM) organization, proteolysis, ECM disassembly, and keratinization. A protein-protein interaction (PPI) network revealed eight hub genes, notably including the up-regulated SPP1 and down-regulated KRT78. Importantly, these hub genes demonstrated correlations with tumor grade, clinical individual cancer stage, and poor prognosis in patients with HNSCC. The comprehensive bioinformatics-driven investigation not only pinpointed co-DEGs but also illuminated associated pathways, providing valuable insights into the molecular mechanisms steering disease progression. These findings have substantial clinical potential, offering avenues for early diagnosis and the development of innovative therapeutic targets for individuals grappling with HNSCC. The identified genes and pathways contribute to a deeper understanding of the intricate molecular landscape of HNSCC, paving the way for more targeted and effective interventions in the clinical setting.
Missing the heart of the matter: Limitations of parental understanding during prenatal consultations for normal fetal echocardiograms
Authors: Angueyra Chantal , Montes-Gil Adriana , Marella Nicole , Glickstein Julie , Goldshtrom Nimrod , Brennan Kathleen
Published: February 2024

Background
Congenital heart disease is the most common congenital malformation worldwide. Prenatal diagnosis provides the opportunity to counsel parents and help them prepare for their future with their child. This study aimed to assess parental knowledge following a prenatal consultation with a pediatric cardiologist for a normal fetal echocardiogram. Improved parental communication in prenatal consultations with pediatric cardiologists is critical to improving outcomes for these children and their families.
Methods.
This prospective questionnaire based descriptive study was conducted at a single regional perinatal center with a level four neonatal intensive care unit and a dedicated infant cardiac intensive care unit. After prenatal consults with a pediatric cardiologist, surveys were administered to consenting parents that received a normal fetal echocardiogram result and their pediatric cardiologists.
Results
From November 2020 to April 2021, 50 parents completed the survey, 34 of whom reported English as their primary language. Of the 16 parents reporting a different primary language, ten parents preferred the consultation to occur in English, and six preferred the consultation in Spanish. Multivariate regression analysis revealed that the presence of a language barrier was associated with decreased understanding of the limitations of a normal fetal echocardiogram (14% vs 84%, p < 0.001) and follow-up recommendations (29% vs 91%, p < 0.01). There was a trend toward decreased understanding with lower education levels, but this difference was not statistically significant. Despite limitations in comprehension, parents and cardiologists were satisfied with the consults and perceived parental understanding as good or extremely good.
Conclusion
Limited English proficiency is an important barrier to comprehension during prenatal consultations with pediatric cardiologists even when best practices of in-person medical interpreters are used. Objective evaluation of parental understanding is critical given that parents and cardiologists may not accurately perceive limitations in knowledge.
Pollen evolution in the Stryphnodendron clade (Leguminosae, Mimoseae)
Authors: Barduzzi Rafael Fernandes , Barros-Souza Yago , Goicochea Stefany Liau-Kang , Borges Leonardo Maurici
Published: February 2024

Pollen morphology is a valuable tool for understanding plant evolution and taxonomy. In the legume family (Leguminosae), tribe Mimoseae exhibits diverse pollen traits, but their taxonomic implications are not consistently considered. The pollen evolution in the Leguminosae family is marked by conservatism, but also suffers influence of evolutionary pressures, which increases diversity. Here we investigated the pollen evolution of the Stryphnodendron clade (Leguminosae, Mimoseae) and how it relates to changes in generic circumscriptions within the clade. We analyzed six morphological traits (three categorical and three continuous) sourced from herbarium specimens and the literature for 44 taxa. Categorical traits comprised number of units in the dispersal unit, outline, and grain pollen ornamentation, while continuous traits encompassed exine thickness, as well as longer and shorter dispersal unit diameters. All characters were mapped over a comprehensive phylogenetic hypothesis for the clade using stochastic character mapping and maximum likelihood estimations. Our results reveal that some traits, such as grain number and outline, are generally more conserved than others, such as pollen ornamentation and continuous traits, which are more labile. Pollen ornamentation is different between two distinct lineages within the Stryphnodendron clade, each including multiple genera. Continuous traits, on the other hand, show a contrasting pattern for the recently described genusGwilymia. In conclusion, although pollen traits are in general conserved within the Stryphnodendron clade, they support recognition of distinct lineages both above and at the genus level. These findings highlight the importance of incorporating pollen morphology in future assessments of generic delimitation within the legume family.
MPEK: a multi-task learning based on pre-trained language model for predicting enzymatic reaction kinetic parameters
Authors: Jiang Hui , Wang Jingjing , Yang Zhijiang , Chen Chang , Yao Ge , Bao Shaoheng , Wan Xiukun , Ding Junjie , Wang Liangliang
Published: February 2024

Enzymatic reaction kinetics are central in analyzing enzymatic reaction mechanisms and target-enzyme optimization, and thus in biomanufacturing and other industries. The enzyme turnover number (kcat) and Michaelis constant (Km), key kinetic parameters for measuring enzyme catalytic efficiency are crucial for analyzing enzymatic reaction mechanisms and the directed evolution of target enzymes. Experimental determination of kcat and Km is costly in terms of time, labor, and cost. To consider the intrinsic connection between kcat and Km and further improve the prediction performance, we propose a universal pre-trained multi-task deep learning model, MPEK, to predict these parameters simultaneously while considering pH, temperature, and organismal information. MPEK achieved superior predictive performance on the whole test dataset. Using the same test dataset, MPEK outperformed other state-of-the-art models. More importantly, MPEK was able to reveal enzyme promiscuity and was sensitive to slight changes in the mutant enzyme sequence. In addition, in three case studies, it was shown MPEK has the potential for assisted enzyme mining and directed evolution. To facilitate in silico evaluation of enzyme catalytic efficiency, we have established a web server implementing this model (http://mathtc.nscc-tj.cn/mpek).
Impact of Tamm Plasmon Structures on Fluorescence and Optical Nonlinearity of Graphene Quantum Dots
Authors: Elamkulavan Hasana Jahan , Purayil Nikhil Puthiya , Subramaniam Sanjay , Keloth Chandrasekharan
Published: February 2024

Graphene Quantum Dots (GQDs) are crucial in biomedicine for sensitive biosensing and high-resolution bioimaging, and in photonics for their nonlinear optical properties. Integrating GQDs with photonic structures, enhances optical properties, optimizing light-matter interactions and enabling precise control over resonance wavelengths. Tamm Plasmon Cavity (TPC) structures are pivotal in photonics, offering innovative solutions to traditional plasmonic limitations. In this work, we explore a facile synthesis method of GQDs by laser irradiation and highlight the transformative potential of TPC structures in amplifying the properties of nanomaterials like GQDs. The characterization of GQDs reveals their exceptional properties, including efficient optical limiting, and stable photoluminescence. The study demonstrates that the TPC structure significantly amplifies the nonlinear optical effects due to the high light-matter interaction indicating the potential for advanced optical systems, including optical limiters and nonlinear optical devices. Furthermore, introducing GQDs into the TPC structure leads to a significant enhancement and tuning of fluorescence emission. The Purcell effect, in combination with the confined electromagnetic fields within the TPC, increases the spontaneous emission rate of GQDs and subsequently enhances fluorescence intensity. This enhanced and tunable fluorescence has exciting implications for high-sensitivity applications like biosensing and single-molecule detection.