bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal adaptation: Geographic photoperiod-temperature patterns explain genetic variation in the common vole Tsh receptor
Authors: Rosmalen Laura van , Schepers Robin , Hao Wensi , Przybylska-Piech Anna , Herman Jeremy , Stojak Joanna , Wójcik Jan , Zande Louis Van de , Searle Jeremy , Hut Roelof
Published: May 2022

The vertebrate photoperiodic neuroendocrine system uses photoperiod as a
proxy to time annual rhythms in reproduction. To investigate seasonal
adaptation in mammals, the hinge region and the first part of the
transmembrane domain of the Tshr gene were sequenced for 278
common vole (Microtus arvalis) specimens from 15 localities in
Western Europe, and 28 localities in Eastern Europe. Forty-nine single
nucleotide polymorphisms (SNPs; 22 intronic, 27 exonic) were found, with
weak or zero correlation with pairwise geographical distance, latitude,
longitude and altitude. By applying a temperature threshold to the local
photoperiod-temperature ellipsoid, we obtained a predicted critical
photoperiod (pCPP) as a proxy for spring onset of local primary food
production (grass). The pCPP obtained explains the distribution of
genetic variation in Tshr in Western Europe through highly
significant correlations. Thus, Tshr, which plays a pivotal role
in the sensitivity of the mammalian photoperiodic neuroendocrine system,
was targeted by natural selection, resulting in optimized timing of
seasonal reproduction.
Retrograde Washout of a Pre-pump LVAD thrombosis in a patient on HeartWare™ support.
Authors: Elbayomi Mohamed , Weyand Michael , Heim Christian , Steger Katrin , Tandler med. Rene
Published: May 2022

The success of the left ventricular assist device (LVAD) as a treatment
for terminal left-side heart failure is still restrained by some severe
complications associated with mechanical circulatory support. Pump
thrombus still affects many patients. It is associated with high
morbidity and mortality. The therapeutic options include augmentation of
anticoagulation and antiplatelet medication, intravenous or
catheter-guided thrombolysis, and pump exchange. Heart transplantation
would be a desirable option in this population, but unfortunately, it is
only theoretical given the increasing number of LVAD implants and
decreasing number of organ donors. A retrograde washout maneuver may be
a treatment option in pre-pump thrombosis in selected patients.
Therefore, the decision should be made on an individual basis after
balancing the risks and benefits of different treatment approaches.
Clinical Outcomes of Pfizer-BioNTech COVID-19 Vaccine on Children and Adolescents: Where do we Stand?
Authors: Al-Qudimat Ahmad , Al-Zoubi Raed , Elaarag Mai , Nashwan Abdulqadir , Hamze Afaf , Bawadi Hiba , Yassin Aksam , Assim Aseel , Aboumarzouk Omar , Zarour Ahmad , Al-Ansari Abdulla
Published: May 2022

Background: The BioNTech-Pfizer vaccine is the only vaccine offered to
children among all available vaccines. However, limited evidence is
available about the clinical outcomes of COVID-19 vaccines, especially
among children and adolescents. This review offers a comprehensive and
up-to-date overview of the BioNTech-Pfizer vaccine’s current information
on children and adolescents. Methods: The review was conducted following
the PRISMA guidelines; a comprehensive search was performed in PubMed,
Scopus, MEDLINE, and EMBASE databases for research publications COVID-19
published between December 2019 and October 2021. All studies reporting
on the outcomes of vaccinating children in their respective institutes
were included. Results: A total of 78 vaccinated children and
adolescents from 6 studies were included. The majority of symptomatic
vaccinated pediatrics were males (71%). The mean age was 15.6 years,
and the BMI was 24.1. The most common clinical symptoms were found in
chest pain (35%), fever (32%), and myalgia (17%). The most common
cardiac symptom in the EKG results was ST elevation, and 35% of
vaccinated pediatrics had elevated serum troponin. The hospitalization,
including ICU admission, was lower than in unvaccinated groups.
Statistically significant associations (P = <0.05) were found
in two symptoms (fever and headache) between the vaccinated and
non-vaccinated pediatric groups. Conclusions: Although we found better
outcomes in the vaccinated group versus the non-vaccinated pediatric
group, more studies are still crucial to further understand the specific
etiology underlying post-vaccination, particularly myocarditis,
psychological impact, and other cardiac clinical symptoms in children
and adolescents after receiving the BioNTech-Pfizer vaccine.
Real-Time Monitoring of Early Cell Death in Mammalian Cell Culture using Capacitance Spectroscopy
Authors: Wu Suyang , Ketcham Stephanie , Corredor Claudia , Both Douglas , Drennen James , Anderson Carl
Published: May 2022

Previous work developed a quantitative model using capacitance
spectroscopy in an at-line setup to predict the dying cell percentage
measured from a flow cytometer. This work aimed to transfer the at-line
model to monitor lab-scale bioreactors in real-time, waiving the need
for frequent sampling and enabling precise controls. Due to the
difference between the at-line and in-line capacitance probes, direct
application of the at-line model resulted in poor accuracy and high
prediction bias. A new model with a variable range that had similar
spectra shape across all probes was first constructed, which improved
the prediction accuracy. Moreover, the global calibration method
included the variance of different probes and scales into the model,
reducing the prediction bias. External parameter orthogonalization also
mitigated the interference from feeding, which further improved the
model performance. The culture evolution trajectory predicted by the
in-line model captured the cell death and alarmed cell death onset
earlier than the trypan blue exclusion test. In addition, incorporation
of at-line spectra following orthogonal design into the calibration set
is more likely to generate robust calibration models than the
calibration models constructed using the in-line spectra only. This is
advantageous, as at-line spectra collection is easier, faster, and more
material-sparing than in-line spectra collection. The root-mean-square
error of prediction of the final model was 6.56% (8.42% of the
prediction range) with an R2 of 92.4%.
Regulator Continuity and Decision-Making Quality: Evidence from SEC Comment Letters
Authors: Kubic Matthew , Toynbee Sara
Published: May 2022

Staff at the U.S. Securities and Exchange Commission (SEC) conduct recurring reviews of firms’ filings to deter misconduct and facilitate investor access to high-quality information. We identify the names of SEC staff who work on a comment letter and examine whether their prior involvement (i.e., continuity) is associated with comment letter quality. Our results are consistent with continuity leading to lower-quality comment letters. Continuity is associated with fewer substantive comments, agreed-upon disclosure changes, and greater similarity between consecutive comment letter reviews. These results are consistent with continuity increasing staffs’ tendency to focus on familiar issues and overlook other areas of potential deficiencies. Time, changes in firms’ operations, and increasing staffs’ feelings of accountability can mitigate the negative effect of continuity on comment letter quality. Our study suggests benefits to a fresh perspective in regulatory monitoring.

JEL Classifications: G18; M41; M48.
Pharmacokinetics and Bioequivalence of Methylphenidate Hydrochloride 10 mg Immediate-Released Tablets in Healthy Thai Volunteers under Fasting Conditions
Authors: V Khaowroongrueng
Published: May 2022

Methylphenidate is a central nervous system stimulant indicated for attention deficit hyperactivity disorder (ADHD) and narcolepsy. Methylphenidate GPO ® had been developed as a generic alternative to Ritalin ® 10 for Thai people. The aims of this study were to characterize pharmacokinetics in Thai population, and to evaluate bioequivalence of Methylphenidate GPO ® to Ritalin ® 10 to support product registration. A comparative dissolution test was performed in four dissolution media, followed by an open-label, randomized, two-way crossover bioequivalence study under fasting conditions. A single dose of the test or reference product was administered in period I and switched over to another product in period II after 7-day washout period. Blood samples were collected at predefined time points over 24 hours after dosing. Plasma concentrations of methylphenidate were quantified using a validated liquid chromatography-mass spectrometry method. The pharmacokinetics was characterized from plasma concentration-time profile following administration of the test and reference formulations. The pharmacokinetic parameters were in agreement with the previously published data. The AUC 0-t , AUC 0−∞ and C max of two methylphenidate 10 mg tablet formulations were statistically compared in 23 healthy Thai volunteers. The analysis of variance (ANOVA) did not show any significant difference between the formulations. The ratios for geometric least-square means and 90% confidence intervals of log-transformed parameters were within the acceptance range of 80.00–125.00%. Both products were generally well tolerated by healthy Thai subjects. Methylphenidate GPO ® and Ritalin ® 10 were bioequivalent in terms of rate and extent of absorption, and could be used interchangeably.
Effect of Food on Bioavailability of Drug through Gastro-Retentive Drug Delivery System
Authors: S Shidhaye
Published: May 2022

Gastro retentive drug delivery systems (GRDDS) have been explored for controlling the release of the drugs by oral administration. However, since these systems are intended to reside in the gastric region for longer period of time, several factors are expected to hamper the absorption rates of the drug in GRDDS. These systems are in contact with the gastric content for longer time and thus, “Food” is expected to interfere with the rate of absorption from these systems. This article focuses on various foods related factors responsible for affecting absorption from the GRDDS type of novel system.
Plasma Technology: An Ultimate Solution for Solid Waste Management
Authors: M Kumar
Published: May 2022

The growth of the population is related to urbanization, development, and industrialization. There found a strong correlation between population, industrialization, and waste production. The famous thermodynamics laws offer insights into the technological/marketing impact on waste production and energy conversion processes. The conventional methods such as land filling, combustion, gasification, incineration, etc. not enough to manage such a huge volume of waste. The non-segregation tendency, consumerism nature makes this waste management work problematic. The paper studies the natural efficiency in the waste management system and also the inability of traditional technology's to handle rapidly increasing waste volume. The plasma-based waste technology is similar to the natural waste management cycle, but with high volume capacity in a short duration. This also has a scope of waste to energy (WtE) conversion. Though plasma has high installation and maintenance costs, revenue generation from byproducts like syngas and slag will create it financially viable.
Providing Safe Drinking Water in the Himalayas: A Tale of Two Cities
Authors: NB Ravinder
Published: May 2022

Water contamination and the associated morbidity and mortality are among the major areas of concern for the planners and policy makers in the developing countries. Situation in the Himalayan region is no different. This study focuses on the analysis of water quality in the two major cities in the western Himalayas namely Shimla and Kathmandu. Divided in four parts, part II of the paper presents the study context and problem diagnostics. Part III is devoted to key concerns and the way forward. Finally, part IV presents conclusions and the research agenda. It is argued that among the factors that are responsible for this outcome are: primitive water treatment technologies, lack of good sanitary practices, lack of ecosystem focused water governance, and absence of effective water quality monitoring and surveillance. Therefore, effective water and sanitation management requires a holistic approach that takes a multidimensional view beyond the traditional confines of technology.
PERANCANGAN PEMODELAN BASIS DATA SISTEM INFORMASI SECARA KONSEPTUAL DAN LOGIKAL
Authors: Pradipta Rio Ariestia , Wintoro Puput Budi , Budiyanto Deny
Published: May 2022

Pengembangan sebuah sistem informasi tidak lepas dengan adanya pengembangan basis data yang dapat menunjang pengelolaan dan penggunaan data pada sebuah sistem yang berjalan. Basis data yang baik dikembangkan dengan menerapkan metode Database System Development Lifecycle (DBSDLC) yang mencakup fase pengembangan Database Design. Dalam fase ini dibuat model database meliputi pengembangan sisi konseptual dan logikal. Pada penelitian ini kami membuat model basis data konseptual dan logikal yang akan diterapkan pada sebuah sistem informasi berbasis website. Tujuan dari fase database design untuk merancang struktur basis data yang sesuai dengan kebutuhan pengguna dan mendapatkan basis data yang handal untuk diterapkan pada sistem berbasis website yang dibangun. Dari penelitian ini dihasilkan rancangan model basis data yang selanjutnya dapat diterapkan pada fase implementasi sistem berbasis website.
Pendampingan Pembuatan Dan Launching Rumah Produksi Sabun Di Desa Fajar Baru Jati Agung
Authors: Widiarto Sonny , Suharso Suharso , Nurhasanah Nurhasanah , Supriyanto R , Kiswandono Agung Abadi
Published: May 2022

Desa Fajar Baru merupakan daerah pemukiman di Kecamatan Jati Agung dengan jumlah tujuh dusun. Masyarakatnya bekerja sebagai tani, buruh dan pegawai swasta serta wiraswasta industri kecil. Kedekatan dengan pasar tradisional, mini market, kuliner malam, lembaga pendidikan dan Kota Bandar Lampung memberikan peluang wirausaha. Tujuan kegiatan pengabdian kepada masyarakat ini adalah pendampingan pembuatan sabun krim dan peluncuran (launching) Rumah Produksi Sabun. Peserta kegiatan ini adalah ibu-ibu Kelompok Usaha Bersama (KUB) Mulya Mandiri di Kelurahan Fajar Baru sebanyak 25 orang. Kegiatan ini terdiri dari sosialisasi, diskusi, demonstrasi dan praktik langsung. Tim Pengabdian Unila telah berhasil meluncurkan Rumah Produksi Sabun dengan produk utama sabun cair-krim. Peluncuran Rumah Produksi langsung diresmikan oleh Ketua PKK dan dihadiri oleh Kepala Desa Fajar Baru. Kegiatan pengabdian ini berhasil meningkatkan pengetahun pengelolaan pembuatan sabun dan pemahaman kewirausahaan serta pemasaran sebesar 23% (66,5% menjadi 89,5%).
Pengolahan Sampah Plastik Menjadi Paving Block di Desa Margasari, Lampung Timur
Authors: Riniarti Melya , Rahmawati Winda , Priyambodo Priyambodo , Tristiyanto Tristiyanto , Marcus Patrice Kevin , Febrina Putri Ayu , Yunita Eva
Published: May 2022

Kebiasan masyarakat membuang sampah ke badan air menjadi masalah serius karena sampah terakumulasi di hutan mangrove. Sampah plastik dapat menyebabkan kematian tanaman mangrove dan mengancam kelestarian hutan mangrove di Desa Margasari. Inovasi yang ditawarkan dalam kegiatan pengabdian kepada masyarakat ini adalah eco paving block. Produk ini tidak rumit pembuatannya dan membutuhkan sampah plastik dalam jumlah besar. Tujuan kegiatan ini adalah (1) meningkatkan pengetahuan dan keterampilan masyarakat dalam mengolah dan memanfaatkan sampah plastik dan (2) meningkatkan daya tarik eduwisata Lampung Mangrove Centre. Kegiatan diawali dengan penyuluhan dilanjutkan dengan pelatihan pembuatan paving block. Hasil evaluasi 20 orang peserta menunjukkan bahwa terjadi peningkatan pengetahuan tentang bahaya plastik bagi ekosistem mangrove dan peserta mampu membuat paving block dengan baik. Peserta sangat antusias dan berharap kegiatan ini dapat diduplikasi kepada lebih banyak warga masyarakat.
DİJİTALLEŞMEDE MOBİL SAĞLIK İŞ MODELLERİ
Authors: ÇİLLİOĞLU KARADEMİR Aslı , AKÇA Yaşar
Published: May 2022

Endüstri 4.0’da dijital teknoloji ve dijital dönüşüm tüm dünyada işletmeler üzerinde önemli etkiler oluşturmaktadır. Dijital dönüşüm özellikle örgüt yapılarında, işleyiş, süreç ve iş modellerinde değişikliklere yol açmaktadır. Bu değişimi yaşamakta olan alanlardan biri sağlık teknolojileridir. Sağlık alanında kullanılmakta olan mobil sağlık (m-Sağlık) uygulaması sayesinde uzaktan izleme ve herhangi bir yerden erişim gerçekleşmektedir. Kullanıcılara sunulan mobil sağlık hizmetleri sayesinde örgütlerin iş süreçleri yeniden değişmektedir. Ayrıca örgütlere yeni iş modelleri sunmaktadır. Aynı zamanda, işletmenin iş değer zinciri üzerinde entegrasyon sağlanmaktadır. Hastaneler ve hastalar başta olmak üzere çok çeşitli paydaşlardan meydana gelen ekosistemler oluşmaktadır. Alan yazındaki çalışmalar incelendiğinde, dijitalleşme ve akıllı uygulamalar konusunun ele alındığı ancak işletmelere yansıyacak olası iş modeli süreçlerine yeterince odaklanılmadığı görülmektedir. Söz konusu eksikliği gidermek amacıyla bu çalışmada, Türkiye’de mobil sağlık hizmetleri iş modelleri incelenmiş ve mevcut durum ortaya konulmuştur.
Kontribusi Kepemimpinan Kiai Dalam Pengembangan Kewirausahaan Pondok Pesantren
Authors: Supriyanto Supriyanto , Yulhendri Yulhendri , Safitri Delvia , Sudjatmoko Agung , Slamet Afi Rachmat
Published: May 2022

Leadership in Islamic boarding schools is the leadership of caregivers or called cleric or master teachers. Leadership in developing entrepreneurship is also in the clergy. This study aims to interpret the role of cleric leadership in the development of entrepreneurship in Islamic boarding schools. This research uses a case study at the Sidogiri Islamic boarding school, Pasuruan. The unit of analysis of the research is ulama, teacher or cleric, business unit management, santri, community members of Islamic boarding school cooperatives. Data collection methods used in-depth interviews, participatory observation and content analysis of documentation. This research design uses a qualitative design with a case study model. Data analysis and data validity testing used triangulation techniques, namely source triangulation, method triangulation and time triangulation. The findings of this study indicate that Kiai's leadership plays an important role in the development of pesantren entrepreneurship. Kiai's important roles are (1) initiating, (2) facilitating, (3) mobilizing teachers, santri, and wali santi, and (4) mobilizing alumni to become investors in the pesantren business unit. Kiai also play a role in collaborating with other parties and the surrounding community.
The Effects of Consumer Behavior and Digital Literacy on Consumption Patterns in Students
Authors: Fitri Nur , Herawan Endang , Febianti Yopi Nisa
Published: May 2022

This research attempted to figure out: the partial effect of consumer behavior on consumption patterns among students, the partial effect of digital literacy on consumption patterns among students, and the simultaneous effect of consumer behavior and digital literacy on consumption patterns among students. It used a quantitative method, with the population of this research being students of the Faculty of Teacher Training and Education of Universitas Swadaya Gunung Jati in Academic Year 2018–2019, from which a sample of 82 respondents were extracted. Data analysis was conducted using a descriptive analysis and an inferential statistical analysis using SPSS 25. The findings showed the following: 1) Consumer behavior had a significant positive effect on consumption patterns among students, because tcount (3.224) > ttable (1.994), consumer behavior was considered to have a partial influence on consumption patterns among students. 2) Digital literacy was also found to have a significant positive effect on consumption patterns among students, because tcount (2.686) > ttable (1.994), digital literacy was considered to have a limited influence on student consumption patterns. Lastly, consumer behavior and digital literacy had a simultaneous effect on consumption patterns among students, because it was found that Fcount (10.76) > Ftable (3.09).
Efek Good Corporate Governance Dan Rasio Keuangan Terhadap Pengungkapan Enterprise Risk Management
Authors: Noviana Dewi , Mappadang Agoestina
Published: May 2022

The purpose of this study is to clarify how good corporate governance and financial ratios affect a company's risk management. Data and information on ERM, obtained from annual reports, management reports and annual corporate governance. The purposive examining method turned into applied in determining the take a look at gotten through 34 groups from fifty seven basis department groups recorded at the Indonesia Stock Exchange with six years of remark from 2015 to 2020, in order that 204 look at take a look at had been gotten. The findings of this look at found out that Good Corporate Governance, particularly the Independent Board of Commissioners, Audit Committee, Risk  Management Committee, and Leverage, had no giant effect at the Company`s Risk  Management, while Profitability had a giant high quality effect at the ranges of company threat control in infrastructure groups indexed at the Stock Exchange. Indonesian Securities for the 2015-2020 period. However, as a whole, the ERM chart for the 2015-2020 period, when companies participate in the Enterprise Risk Management Index, combines the presence of independent, audit and risk  Management committees, leverage and profitability factors. Affects the index. Measures infrastructure companies listed on the Indonesia Stock Exchange. Another result of this study is that the most common type of risk is financial risk.
Pengaruh Pembelajaran Daring terhadap Learning Loss dan Implikasinya terhadap Learning Outcome
Authors: Solihat Ai Nur , Sadiah Ati , Gumilar Gugum
Published: May 2022

The purpose of this study was to collect data and analyze the effect of online learning on learning loss and its consequences for learning outcomes. This study employs an explanatory survey technique with saturated sampling. This study surveyed 97 students from the Department of Economics Education at FKIP Siliwangi University. To obtain information about the variabels associated with online learning, learning loss, and learning outcomes, descriptive analysis using the SPSS 24 application was used, whereas path analysis using the AMOS application was used to determine the direct and indirect effects of online learning on learning loss and learning outcomes. The results indicated that online learning at the Department of Economics Education FKIP Siliwangi University had a strong categorization tendency, while the learning loss and learning outcome variabels had a moderate categorization tendency. Online learning has a 65.9 percent effect on learning loss and a 67.7 percent effect on learning outcomes.
Inovasi untuk Keberlanjutan Usaha Kuliner
Authors: V Yuhendri L
Published: May 2022

This research aims to describe the innovations made by sanjai entrepreneurs for the sustainability of culinary businesses in Bukittinggi City. The research approach is qualitative research with a type of phenomenology research. Sampling techniques use snowball sampling. The key informant is sanjai entrepreneurs. Data collection techniques use in-depth interviews, participation observations, and documentation. Data analysis techniques use miles, huberman, & saldana qualitative research data analysis processes. The results showed that the source of entrepreneurial innovation ideas was obtained from watching videos on Youtube, modeling similar businesses, modeling other different businesses, the result of self-thought, and seeing business products at exhibitions. Forms of innovation carried out by sanjai entrepreneurs are product innovation, technology innovation, and service innovation. The impact of innovation on business sustainability is that products are favored by consumers, consumers increase, revenue increase, profits increase, businesses survive and are sustainable.  The results of the research can be used as a reference for culinary entrepreneurs in innovating for the sustainability of culinary businesses.
Visibility, Credibility, Attraction dan Power Brand Ambassador Mempengaruhi Brand Image Produk Mie Sedaap Pada Mahasiswa
Authors: Hayati Annur Fitri , Damanik Noveline Patricia
Published: May 2022

The purpose of this study was to determine the effect of visibility, credibility, attraction, power brand ambassador to brand Image of Mie Sedaap on students of the Faculty of Economics, Padang State University. This type of research is causative. The population in this study were students of the Faculty of Economics, Padang State University. The number of research samples based on William Cochran's formula was 97 people and selected using the Purposive Sampling technique. The data used is the type of primary data obtained through distributing questionnaires to students of the Faculty of Economics, Padang State University with predetermined criteria. The analytical method used is multiple regression analysis using SPSS 22. The results show that (1) Visibility, credibility, attraction and power of brand ambassadors together have a significant effect on Mie Sedaap's brand image in students of the Faculty of Economics, Padang State University with a value of 50.0% while the rest are other variables that were not investigated. (2) Visibility credibility, attraction and power of brand ambassadors each have a significant effect on Mie Sedaap's brand image on students of the Faculty of Economics, Padang State University. (3) Visibility brand ambassadors have the most influence. strong with a Beta value of 27.7% compared to the variables of credibility, attraction, power ambassador on the brand image of Mie Sedaap Products at the students of the Faculty of Economics, Padang State University.
Reformasi Birokrasi di Badan Pusat Statistik Kota Palembang
Authors: Holipah Holipah , Asmawati Asmawati
Published: May 2022

This research is a policy study that discusses the efforts of the Central Statistics Agency for the City of Palembang in implementing bureaucratic reform. Based on the results of this study, the results of research and discussion show that this study aims to analyze the implementation of Presidential Regulation Number 81 of 2010 concerning Bureaucratic Reform at the Palembang City BPS Office, and to gain an understanding of the meaning of Bureaucratic Reform for Palembang City BPS office employees. This research method is qualitative. Primary data were collected through observation and interviews, while secondary data were obtained from documentation and literature studies that were relevant to the research object. The parameters measured are based on the implementation model of bureaucratic reform from aspects that include aspects of the institution (organization), management and human resources of the apparatus. In its implementation, it still encounters various kinds of obstacles, the main obstacles are the coordination of the Palembang City BPS Technical Team is still not at the Palembang City BPS itself but is in other agencies. The process of bureaucratic reform is certainly still far from what is expected by the community.
Development of Single Variable Linear Equation System Question Instruments Based on Higher Order Thinking Skill (HOTS)
Authors: Maratin Hidayatul , Shodikin Ali
Published: May 2022

Kurikulum 2013 menuntut peserta didik agar dapat berfikir tingkat tinggi atau HOTS yang sesuai dengan kebutuhan kompetensi di abad ke 21. Berdasarkan hasil penelitian menyatakan jika, peringkat peserta didik di Indonesia masih relatif rendah, dikarenakan peserta didik masih lemah dalam menyelesaikan soal yang membutuhkan penalaran dan analisis. Maka dapat disimpulkan bahwa tujuan dari penelitian ini yaitu, untuk mengembangkan soal SPLSV yang berbasis HOTS di SMP/MTs yang valid, praktis serta efektif. Penelitian ini merupakan penelitian pengembangan (Research and Development). Subjek ujicoba dalam penelitian ini merupakan siswa kelas VII di MTS I Attanwir, dengan jumlah populasi sebanyak 40 siswa, dan untuk memfokuskan data, dipilih 3 siswa yang mewakili dari kemampuan tinggi, sedang, dan rendah. Analisis yang digunakan dalam penelitian ini adalah uji validitas oleh pakar ahli materi, keabsahan soal, daya pembeda, tingkatan kesulitan, reabilitas test, dan pengujian t-test. Hasil penelitian mengemukakan bahwa seperangkat instrumen soal SPLSV dapat digunakan untuk melatih kemampuan befikir tingkat tinggi pada peserta didik.
Pembinaan Karakter Siswa Melalui Program Islamic Studies di SD Bosowa Al-Azhar Cilegon
Authors: Lidiana Nanda , Robiansyah Firman , Darmawan Darmawan
Published: May 2022

Education plays a role in character building. This study aims to determine, analyze, and describe the implementation of the Islamic Studies program, character values, and the implications of the Islamic Studies program on student character building. This research is a qualitative research with case study method. Data collection used: observation, interviews, documentation studies, and questionnaires. Based on the results of the study, it was concluded that: 1) in limited face-to-face learning, the implementation of the Islamic Studies program went well, 2) the character values ​​in the Islamic Studies program included: religious, hard work, responsibility, fond of reading, disciplined, independent, love peaceful, appreciative of achievement, and communicative, 3) the implementation of the Islamic Studies program has significant implications for the character building of students with 84% of students responding correctly and 16% of students answering incorrectly. The Islamic Studies program is recommended for other schools as an effort to build character.
Meningkatkan Motivasi Belajar Siswa Pada Mata Pelajaran Matematika Dengan Model Pembelajaran Course Review Horay
Authors: Andhika Muhammad Rezki , Mauliza Mauliza
Published: May 2022

Penelitian ini dilatarbelakangi pada rendahnya motivasi belajar siswa pada mata pelajaran matematika. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada perubahan motivasi belajar siswa setelah penerapan model pembelajaran course review horay. Penelitian ini menggunakan pendekatan pre eksperimen, sampel dalam penelitian ini siswa kelas III MIN 8 Aceh Barat, yang berjumlah 37 siswa kelas III-A, instrumen yang digunakan yaitu angket, observasi dan dokumentasi. Data dikumpulkan menggunakan angket tertutup, teknik analisis data dilakukan dengan analisis deskriptif dan komparatif dengan SPSS. Hasil penelitian diperoleh sebelum penerapan model pembelajaran course review horay terdapat 21 orang siswa yang motivasinya rendah, 13 orang siswa yang motivasinya sedang dan 3 orang siswa yang motivasinya tinggi dengan nilai rata-rata 36,34. Sedangkan setelah penerapan model pembelajaran course review horay tidak terdapat siswa yang motivasinya rendah, 3 orang siswa motivasinya sedang dan 34 orang siswa motivasinya tinggi dengan nilai rata-rata 68,8. Dapat disimpulkan bahwa ada perubahan motivasi belajar setelah penerapan model pembelajaran course review horay.
48-60 aylık çocuklarda sembolik oyun ve bilişsel işlevler “Oyun ve Biliş”
Authors: Güney Mehmet , Baran Gülen
Published: May 2022

Bu çalışmada okul öncesi eğitim kurumlarına devam eden çocukların sembolik oyun becerilerini değerlendirmek, etkili olabilecek etmenleri ortaya koymak, bilişsel işlevler ile sembolik oyun becerileri arasındaki ilişkiyi incelemek amaçlanmıştır. Araştırmada çalışma grubu anaokullarına devam eden 48-60 ay aralığındaki 100 çocuktan oluşmuştur. Çalışma kapsamında çocukların bilişsel işlevlerini değerlendirmek için “Bilişsel İşlevlerin Uygulanması Ölçeği” , sembolik oyun becerilerini değerlendirmek için “Sembolik Oyun Testi” kullanılmıştır. Araştırma sonuçlarında, sembolik oyun açısından kızlar lehine anlamlı bir sonuç çıktığı, yetişkin desteğinin çocukların ön test son test puanları arasında fark yarattığı ve bilişsel işlevlerin sembolik oyunun anlamlı bir yordayıcısı olduğu görülmüştür.
Okul öncesi çocuklarda çalışma belleği ve erken okuryazarlık becerilerinin incelenmesi
Authors: Sağlam Cansu , Özyürek Arzu
Published: May 2022

Bu çalışma, okul öncesi çocukların çalışma belleği ve erken okuryazarlık becerilerini incelemek amacıyla yapılmıştır. Çalışma grubunda okul öncesi eğitime devam eden ve rastgele örnekleme yöntemiyle seçilen 5-6 yaşındaki 100 çocuk yer almıştır. Veri toplamada, Okul Öncesi Çocuklar İçin Bellek Bataryası ve Erken Okuryazarlık Becerilerini Değerlendirme Aracı (EOBDA) kullanılmıştır. Veriler, Mann Whitney U Testi, Kruskal Wallis-H Testi ve Spearman Brown Korelasyon Katsayısı ile analiz edilmiştir. Değişkenler ve ölçek puanları arasında fark olması durumunda, farkın kaynağının belirlenmesinde Tukey Testi kullanılmıştır. Çalışma sonucunda erkek çocukların Çalışma Belleğinde görsel mekansal bellek becerilerinin kız çocuklarından daha yüksek olduğu bulunmuştur. Çocukların çalışma belleği ve erken okuryazarlık becerileri arasında anlamlı ve pozitif yönde bir korelasyon belirlenmiştir. Özellikle çalışma belleği ve sesbilgisel farkındalık becerileri birbiri ile yakından ilişkili bulunmuştur.
Eğitimcilerin Montessori yaklaşımına ilişkin yeterliklerinde Montessori eğitimci eğitim programının etkisinin incelenmesi
Authors: Aral Neriman , Yurteri Tiryaki Aybüke , Fındık Ezgi , Çetin Sultanoğlu Saliha , Beker Esra , Yıldız Bıçakçı Müdriye , Özdoğan Özbal Ece
Published: May 2022

Montessori Eğitimci Eğitim Programının, eğitimcilerin Montessori yaklaşımına ilişkin yeterliklerine etkisini değerlendirmek amacıyla yapılan araştırma 56 (28 deney ve 28 kontrol) eğitimci ile gerçekleştirilmiştir. Araştırma, ön test son test kontrol gruplu 2x2 faktöriyel desende yürütülmüş, veriler araştırmacılar tarafından geliştirilen Genel Bilgi Formu ve Montessori Eğitimine İlişkin Eğitimci Değerlendirme Anketi ile toplanmıştır. Deneysel süreçte deney grubundaki eğitimcilere 160 saatlik Montessori Eğitimci Eğitimi Programı uygulanmıştır. Araştırma bulguları, deney ve kontrol grubunun ön test puanları arasında anlamlı bir fark olmadığını; bunun yanında son test puanları arasında anlamlı bir fark olduğunu göstermiştir. Deney grubunun ön test ve son test puanları karşılaştırıldığında anlamlı bir fark olduğu; buna karşın kontrol grubunda ön ve son test puanları arasında anlamlı bir fark olmadığı belirlenmiştir. Bulgular Montessori Eğitimci Eğitiminin Montessori felsefine ilişkin düşünce, duygu ve davranışlar üzerinde etkili olduğunu göstermiştir. Bulgular ışığında eğitimlerin yaygınlaştırılması, eğitimlerin Montessori felsefesi ve uygulamasına hakim, uluslararası kuruluşlardan eğitim almış kişiler tarafından verilmesi önerilebilir.
Safety and efficacy of drug-eluting microspheres chemoembolization under cone beam computed tomography control in patients with early and intermediate stage hepatocellular carcinoma
Authors: Korsic Spela , Levasic Nastja , Dezman Rok , Zupan Lara Anja Lesnik , Trotovsek Blaz , Jansa Rado , Smid Alojz , Popovic Peter
Published: May 2022

Background

Drug-eluting microsphere transarterial chemoembolization (DEM-TACE) is the standard of care in patients with intermediate-stage hepatocellular carcinoma and ensures targeted and controlled cytotoxic and ischemic effects. Proper patient selection and optimized treatment techniques are associated with longer median survival. The aim of this single-institution retrospective study was to evaluate safety and efficacy of DEM-TACE under cone beam computed tomography (CBCT) control in patients with early and intermediate stage hepatocellular carcinoma.

Patients and methods

A total of 144 patients (mean age 67.9 ± 8.0 years, 127 males and 17 females) between February 2010 and December 2018 were studied. Microparticles of different dimensions according to two manufacturers (diameter of 70–150 μm, 100–300 μm or 300–500 μm and 40-μm, 75-μm or 100-μm) were used and loaded with 50–150 mg of doxorubicin. The objective tumour response according to the modified Response Evaluation Criteria in Solid Tumours (mRECIST), the time to progression, adverse events and overall survival were (OS) evaluated.

Results

In total, 452 procedures were performed (median, 3 per patient). Four (0.9% of all procedures) major complications were noted. Postembolization syndrome occurred after 35% of procedures. At the first imaging follow-up 2–3 months after first treatment, 91% of patients achieved an objective response. The median time to progression was 10.2 months (95% CI: 8.3-12.1 months). OS rates at 1, 2, 3, 4, and 5 years were 85%, 53%, 33%, 20% and 14%, respectively. The median survival time was 25.8 months (95% CI: 22.1–29.5 months).

Conclusions

DEM-TACE under CBCT control in patients with early and intermediate stage hepatocellular carcinoma is a safe and effective method of treatment with high objective tumour response and survival rates.
Persepsi dan Preferensi Kenyamanan Taman Monumen Perjuangan Kapten TNI Anak Agung Gede Anom Mudita
Authors: Wiguna I Gusti Agung Windar Arya , Sugianthara Anak Agung Gede , Astawa I Nyoman Gede
Published: May 2022

Convenience perceptions and preferences Taman Monumen Perjuangan Kapten TNI Anak Agung Gede Anom Mudita. Taman Monumen Perjuangan Kapten TNI Anak Agung Gede Anom Mudita has a strategic location right in the center of the city. The interest and awareness of peoples around to utilization Taman Monumen Perjuangan Kapten TNI Anak Agung Gede Anom Mudita as a public space or public area are quite high. However, the comfort value of this public space is still less, there are no facilities like restroom, benches, gazebos and several elements have been broken like statues, lights, paths as far as plants found at some area with faded condition. Those problems becomes idea and also a goal to find out how visitors perceptions and preferences about Taman Monumen Perjuangan Kapten TNI Anak Agung Gede Anom Mudita. This research used a survey as a method with data collection techniques through observation, interviews, questionnaires, and literature study. The results collected about 55.8% of visitors said enough which was seen from nine indicators including circulation, shelter, noise, smells, shape, security, cleanness, beauty, and facilities with diverse preferences. The suggestion that can be given that the government and the management need to improve maintenance, cleanness and adding more facilities with a good arrangement so Taman Perjuangan Kapten TNI Anak Agung Gede Anom Mudita as a public space or public area can function properly.
Perencanaan Lanskap Agroedutourism di UPT. Sentra Ternak Sobangan, Kecamatan Mengwi, Kabupaten Badung
Authors: Zulfa Zakiyatul , Sugianthara Anak Agung Gede , Suardi I Dewa Putu Oka
Published: May 2022

Agroedutourism Landscape Planning at Sobangan Livestock Center Technical Implementation Unit, Mengwi, Badung. Bali is one of the islands in Indonesia which has natural potential that can be developed as an attraction for tourism. One of them is agroedutourism. Sobangan Livestock Center Technical Implementation Unit is the center of Balinese cattle breeding and education which is managed by the Department of Agriculture and Food of Badung Regency, which has potential land as a tourist attraction. The purpose of this research is to plan a landscape that can support the breeding process of Balinese cattle, education, and can be used as an agroedutourism.This study used a survey method with data collection techniques through observation and literature study . Literature study is applied to obtain the formulation of the concept of agroedutourism. Meanwhile the field survey was applied to determine constraints and potentials to support Landscape planning Sobangan Livestock Center. The results of this research are in the formsite plan of a farm environmental arrangementthat can support the activities of breeding, education and facilities agroedutourism by considering the comfort for livestock and for users on the site.
Perencanaan Ruang Publik Berbasis Data Biofisik di Hulu Tukad Badung, Desa Sempidi, Kabupaten Badung
Authors: Arcana I Gede Bagus Windhu , Asmiwyati I Gusti Agung Ayu Rai , Gunadi I Gusti Alit
Published: May 2022

Public space planning based on biophysic data of upper Tukad Badung, Sempidi Village, Badung District. The Upper Tukad Badung area has the potential for natural sceneries, ecological values and religious socio-culture areas to be developed as a comfortable and safe public zone. The purpose of this research is to identify, analyze the biophysical and social aspects and allocate space for public activities in accordance with the conditions of the Upper Tukad Badung area. The research method used was a survey method using data collection techniques through observation, site documentation, interviews, questionnaires, and literature study. The landscape planning stages included inventory, analysis, synthesis, and landscape planning. The results of spatial synthesis of topographic and vegetation data with descriptive analysis of other data resulted active and passive public zones. The zones were connected with primary and secondary circulation types in a linear pattern. The vegetation plan had three functions;aesthetic conservation, cultivation, and vegetation.
Identifikasi Tipologi Ruang Terbuka Publik Perkotaan Taman Catur Ayani Kota Pontianak, Kalimantan Barat
Authors: Wulandari Agustiah
Published: May 2022

Identification of Typology of Urban Public Open Space Taman Catur Ayani, Pontianak City, West Kalimantan. Open space is the embodiment of urban environmental development. The arrangement of public open spaces affects affecting people in urban areas. Public Open space is a place of recreation and infrastructure for community interaction in urban areas. Taman Catur Ayani is located in Kota Pontianak, Kalimantan Barat Province. This study aims to identify the typology of Non-Green Open Space in Taman Catur Ayani, Kota Pontianak. The research method used is qualitative. It collects data using direct observation of visitors' activities to Taman Catur Ayani. Based on the study results, This park has 5 (five) typological characteristics in Non-Green Open Spaces, namely: plazas, parking lots, sports fields, playgrounds and recreation areas, barriers, and corridors. The dominant activity in Taman Catur Ayani is architectural typology. The function of public space that does not yet exist in this park is incidental. Because it is an open space in the city center, this park cannot accommodate any emergency activities.
Asertivitas Mahasiswa Organisatoris Ditinjau dari Kecerdasan Emosional dan Jenis Kelamin
Authors: Dwilestari Ni Made Ayu Krisna , Widiasavitri Putu Nugrahaeni
Published: May 2022

Assertiveness is the ability to express thoughts, feelings, needs, and desires with confidence that does not harm yourself or violate the rights of others. In college life, students do not just focus on academic activities but also non-academics, such as student organizations. When participating in organizations, students are faced with some situations that require assertiveness skills. Assertiveness can be influenced by two factors, including emotional intelligence and gender. This quantitative research aims to determine the role of emotional intelligence and gender on the assertiveness of Udayana University Medical Faculty students participating in student organizations. The subjects of this research were 120 students of Udayana University Medical Faculty students participating in student organizations. There are two measuring instruments used in this research, that are assertiveness scale and emotional intelligence scale. This research used analysis of covariance or ANOVA as data analysis technique. The results show the significance value on the corrected model is 0.000 (p <0,05). These results show that emotional intelligence and gender altogether contribute to the assertiveness of Udayana University Medical Faculty Students participating in student organizations.
Pengalaman orang tua mendampingi proses belajar anak berkebutuhan khusus selama belajar dari rumah pada masa COVID-19: Studi fenomenologis
Authors: Swandi Ni Luh Indah Desira , Immanuel Aria Saloka , Marheni Adijanti
Published: May 2022

This study aims to understand how parents interpret experiences in assisting children with special needs to learn from home. This research method is phenomenological qualitative with data collection in the form of semi-structured interviews. Interviews were conducted online with three parents of children with special needs obtained by the purposive sampling method. The data obtained were then transcribed and analyzed by Interpretative Phenomenological Analysis (IPA). The results showed that there were several superordinate themes, namely: (1) parents' views on the child's condition, (2) difficulties faced while accompanying children to study, (3) emotional experiences while accompanying children, (4) relationship and social support obtained and expected by parents, (5) worries and future expectation. In this study, parents conveyed their personal experiences and feelings in accompanying children while learning from home. This finding can contribute to the field of educational and clinical psychology as a basis for providing appropriate interventions for parents in assisting children with special needs to learn from home.

Keywords: Children with special needs, learning from home, Covid-19, interpretative phenomenological analysis, parents' experience
PROCENA STANJA I ENERGETSKA SANACIJA VIŠESPRATNE STAMBENE ZGRADE U ULICI DRAGIŠE BRAŠOVANA U NOVOM SADU
Authors: Čančar Sonja
Published: May 2022

Rad se sastoji iz dva dela, teorijsko-istraživačkog i praktičnog dela. U teorijsko-istraživačkom delu su obrađeni malteri i detaljnije termoizolacioni malteri. U praktičnom delu urađena je procena stanja višespratne stambene zgrade u Novom Sadu. Zatim je urađen proračun energetske efikasnosti za postojeće stanje objekta. Nakon predloženih mera energetske sanacije, ponovo je urađen proračun energetske efikasnosti zgrade. Na kraju, upoređeni su dobijeni rezultati ova dva proračuna i predložene mere nekonstrukcijske sanacije celog objekta.
PROCENA STANJA I SANACIONO REŠENJE NOSEĆE AB KONSTRUKCIJE LAMELE C2 URGENTNO-DIJAGNOSTIČKOG CENTRA U NOVOM SADU
Authors: Pujović Đorđe
Published: May 2022

Rad se sastoji iz teorijskog i praktičnog dela. U teorijskom delu opisano je ojačanje AB elemenata CFRP lamelama. U praktičnom delu urađena je procena stanja lamele C2 Urgentno-dijagnostičkog centra u Novom Sadu. Kako bi se utvrdio stepen oštećenja i dao predlog sanacionih radova, sproveden je detaljan vizuelni pregled svih dostupnih elemenata konstrukcije. Zaklju­čeno je da na AB elementima postoje brojni defekti i oštećenja. Na osnovu analize registrovanih defekata i oštećenja i rezultata ispitivanja uzoraka zetih iz konstrukcije, dat je predlog sanacionih mera AB konstrukcije.
ANALIZA RAVNOMERNOSTI INTERVALA SLEĐENjA VOZILA NA LINIJI BROJ 5 U NOVOM SADU SA PREDLOGOM MERA ZA POBOLjŠANjE
Authors: Radojičić Milica , Pitka Pavle
Published: May 2022

Interval sleđenja predstavlja jedan od najznačajnijih dinamičkih elemenata linije, kako sa gledišta organizacije prevoza, tako i sa gledišta kvaliteta prevoza značajnog za putnike. U realnom sistemu na ravnomernost intervala sleđenja vozila utiče veći broj primarnih poremećaja, koji su različiti po mestu i vremenu nastanka. U radu je utvđen stepen ravnomernosti intervala sleđenja i dat je predlog mera za poboljšanje ravnomernosti intervala sleđenja na liniji broj 5.
ATOMSKI DIZAJN SISTEMI
Authors: Stepanović Katarina , Milić Keresteš Neda
Published: May 2022

Industrija dizajna i razvoja softvera se u poslednjim godinama značajno širi, dok se procesi njihove izrade nisu puno menjali. Ovo dovodi do potrebe za sistematizacijom koja olakšava rad novim zaposlenima koji dolaze u kompanije, ali i ljudima koji već rade na postojećem proizvodu. Dizajn sistemi predstavljaju skup vizuelnih vodiča, principa razvoja i biblioteke komponenti koje svi unutar jedne kompanije treba da koriste zarad bržeg i lakšeg razvoja. Ovaj rad predstavlja prikaz kompletnog dizajna jednog dizajn sistema i veb aplikacije za pretraživanje muzeja. Cilj je da se na praktičnom primeru pokaže kako se slaganjem komponenti dizajn sistema dobija gotov proizvod.