bluuebunny/crossref_metadata_2025 huggingface dataset:
Caring of the Fringe? Mediterranean Desertification between Peri-Urban Ecology and Socioeconomics
Authors: Halbac-Cotoara-Zamfir Rares , Marucci Alvaro , Salvia Rosanna , Quaranta Giovanni , Sateriano Adele , Cecchini Massimo , Bianchini Leonardo
Published: January 2022

This commentary debates on the role of multiple socioeconomic drivers of fringe land degradation (including, but not limited to, population and social dynamics, economic polarization, and developmental policies), as a novel contribution to the desertification assessment in Southern European metropolitan regions, a recognized hotspot of desertification at the global scale. Expanding rapidly all over the world, metropolitan regions are a geographical space where land degradation drivers and processes assume typical relationships that require further research supporting dedicated policy strategies. To assure a better comprehension of the environmental-economic nexus at the base of land degradation in peri-urban areas, we provided a classification of relevant socioeconomic and territorial dimensions in both macro-scale and micro-scale degradation processes. We also identified the related (contextual) factors that determine an increased risk of desertification in metropolitan regions. Micro-scale factors, such as agricultural prices and off-farm employment, reflect some potential causes of fringe land degradation, with a mostly local and on-site role. Technological change, agricultural prices, and household income influence land vulnerability, but their impact on fringe land degradation was less investigated and supposed to be quite moderate in most cases. Macro-scale factors such as population density, rural poverty, and environmental policies—being extensively studied on a qualitative base—were taken as important drivers of fringe land degradation, although their impact still remains undefined. Regional disparities in land resource distribution, rural poverty, and unsustainable management of environmental resources like soil and water were indirect consequences of land degradation in peri-urban districts. Based on a comparative review of theoretical and empirical findings, strategies mitigating degradation of fringe land and reducing desertification risk in potentially affected metropolitan regions were finally discussed for the Northern Mediterranean basin and generalized to other socioeconomic contexts.
Confluent Small Bowel Lipomatosis: A Rare Cause of Recurrent Abdominal Pain
Authors: Khanijaun Sukhwant , Cheluvappa Rajkumar , Selvendran Selwyn , Pang Tony
Published: January 2022

Small intestine lipomatosis is rare but may be associated with pain, intussusception, and gastrointestinal bleeding. In this report, we examine the case of a 41-year-old man who had recurrent presentations to the emergency department with non-specific abdominal pain. Preoperative imaging suggested extensive infiltration of small intestine with macroscopic fat. At surgery, extensive and confluent small bowel lipomatosis were seen. The affected ileal segment was resected, and the patient remained symptom-free after surgery. Abdominal lipomatosis is a rare condition which can be completely treated by resection of the affected gut segment but is often unsuspected and difficult to diagnose. In this report, we describe a case with the most extensive lipomatosis on record with more than 70 cm of gut with confluent lipomatosis. Magnetic resonance Enterography (MRE) is a useful non-invasive diagnostic modality, although laparoscopy/laparotomy may be necessary for assessment of the extent of disease. Symptomatic cases should be treated with segmental small bowel resection, which is curative.
Hysteresis Response Loops in Stationary Vibrator Regimes for Elastomeric Insulators
Authors: Bratu Polidor , Dobrescu Cornelia , Drăgan Nicu
Published: January 2022

In order to raise the hysteresis loops in stationary dynamic regimes in the case of elastomeric insulators, specialized dynamic stands are used that may obtain both the necessary harmonic excitation by force as well as the modification of the angular arrangement discreetly variable from zero to 90 degrees. In this context, for the evaluation of the elastomeric insulators, a dynamic stand with an inertial vibrator was used, the frequency of which can be changed by continuous adjustment within the range of values from 2 Hz to 60 Hz. Forces and displacements can be measured with the appropriate sensors, and based on the recording of signals, the characteristics of rigidity, damping and the raise of hysteresis loops could be determined for three significant dynamic regimes: ante-resonance and post-resonance. Research on the dynamic stand, patented in Romania, has highlighted the fact that the parametric evaluation can be performed based on the lifting of the hysteretic loops in stationary harmonic regimes. Additionally, there are two situations specifically mentioned, one in which the significant inertial effect for the F-x loops leads to their positioning in quadrants II and IV, and the case of Q-x loops, where the inertial effect does not exist, and their positioning is only in quadrants I and III. From the analysis of the two cases, the most advantageous evaluation method for the test can be chosen. This article provides the calculation relationships established for the dynamic model with linear viscoelastic behaviour. The requirements of Voight–Kelvin modeling with a single degree of freedom is fully justified and ensured by the conditions of geometric and mass symmetry in the construction of the stand. The verification of the numerical results with the experimental ones was performed with the hysteresis loops corresponding to the previously defined three significant dynamic regimes, as well as according to the three positions of the elastomeric insulators for compression, compression-shear and shear.
Acknowledgment to Reviewers of Thermo in 2021
Authors:   Thermo Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
What Can Resting-State fMRI Data Analysis Explain about the Functional Brain Connectivity in Glioma Patients?
Authors: Sighinolfi Giovanni , Mitolo Micaela , Testa Claudia , Martinoni Matteo , Evangelisti Stefania , Rochat Magali Jane , Zoli Matteo , Mazzatenta Diego , Lodi Raffaele , Tonon Caterina
Published: January 2022

Resting-state functional MRI has been increasingly implemented in imaging protocols for the study of functional connectivity in glioma patients as a sequence able to capture the activity of brain networks and to investigate their properties without requiring the patients’ cooperation. The present review aims at describing the most recent results obtained through the analysis of resting-state fMRI data in different contexts of interest for brain gliomas: the identification and localization of functional networks, the characterization of altered functional connectivity, and the evaluation of functional plasticity in relation to the resection of the glioma. An analysis of the literature showed that significant and promising results could be achieved through this technique in all the aspects under investigation. Nevertheless, there is room for improvement, especially in terms of stability and generalizability of the outcomes. Further research should be conducted on homogeneous samples of glioma patients and at fixed time points to reduce the considerable variability in the results obtained across and within studies. Future works should also aim at establishing robust metrics for the assessment of the disruption of functional connectivity and its recovery at the single-subject level.
Proficiency and Interlaboratory Variability in the Determination of Phthalate and DINCH Biomarkers in Human Urine: Results from the HBM4EU Project
Authors: Mol Hans G. J. , Elbers Ingrid , Pälmke Claudia , Bury Daniel , Göen Thomas , López Marta Esteban , Nübler Stefanie , Vaccher Vincent , Antignac Jean-Philippe , Dvořáková Darina , Hajšlová Jana , Sakhi Amrit Kaur , Thomsen Cathrine , Vorkamp Katrin , Castaño Argelia , Koch Holger M.
Published: January 2022

A quality assurance/quality control program was implemented in the framework of the EU project HBM4EU to assess and improve the comparability of biomarker analysis and to build a network of competent laboratories. Four rounds of proficiency tests were organized for 15 phthalate and two DINCH urinary biomarkers (0.2–138 ng/mL) over a period of 18 months, with the involvement of 28 laboratories. A substantial improvement in performance was observed after the first round in particular, and by the end of the program, an average satisfactory performance rate of 90% was achieved. The interlaboratory reproducibility as derived from the participants’ results varied for the various biomarkers and rounds, with an average of 24% for the biomarkers of eight single-isomer phthalates (e.g., DnBP and DEHP) and 43% for the more challenging biomarkers of the mixed-isomer phthalates (DiNP, DiDP) and DINCH. When the reproducibility was based only on the laboratories that consistently achieved a satisfactory performance, this improved to 17% and 26%, respectively, clearly demonstrating the success of the QA/QC efforts. The program thus aided in building capacity and the establishment of a network of competent laboratories able to generate comparable and accurate HBM data for phthalate and DINCH biomarkers in 14 EU countries. In addition, global comparability was ensured by including external expert laboratories.
Stirred Kardar-Parisi-Zhang Equation with Quenched Random Noise: Emergence of Induced Nonlinearity
Authors: Kakin Polina I. , Reiter Mikhail A. , Tumakova Maria M. , Gulitskiy Nikolay M. , Antonov Nikolay V.
Published: January 2022

We study the stochastic Kardar-Parisi-Zhang equation for kinetic roughening where the time-independent (columnar or spatially quenched) Gaussian random noise f(t,x) is specified by the pair correlation function ⟨f(t,x)f(t′,x′)⟩∝δ(d)(x−x′), d being the dimension of space. The field-theoretic renormalization group analysis shows that the effect of turbulent motion of the environment (modelled by the coupling with the velocity field described by the Kazantsev-Kraichnan statistical ensemble for an incompressible fluid) gives rise to a new nonlinear term, quadratic in the velocity field. It turns out that this “induced” nonlinearity strongly affects the scaling behaviour in several universality classes (types of long-time, large-scale asymptotic regimes) even when the turbulent advection appears irrelevant in itself. Practical calculation of the critical exponents (that determine the universality classes) is performed to the first order of the double expansion in ε=4−d and the velocity exponent ξ (one-loop approximation). As is the case with most “descendants” of the Kardar-Parisi-Zhang model, some relevant fixed points of the renormalization group equations lie in “forbidden zones”, i.e., in those corresponding to negative kinetic coefficients or complex couplings. This persistent phenomenon in stochastic non-equilibrium models requires careful and inventive physical interpretation.
A Geometric Model in 3+1D Space-Time for Electrodynamic Phenomena
Authors: Faber Manfried
Published: January 2022

With the idea to find geometric formulations of particle physics we investigate the predictions of a three-dimensional generalization of the Sine-Gordon model, very close to the Skyrme model and to the Wu-Yang description of Dirac monopoles. With three rotational degrees of freedom of spatial Dreibeins, we formulate a Lagrangian and confront the predictions to electromagnetic phenomena. Stable solitonic excitations we compare with the lightest fundamental electric charges, electrons, and positrons. Two Goldstone bosons we relate to the properties of photons. These particles are characterized by three topological quantum numbers, which we compare to charge, spin, and photon numbers. Finally, we conjecture some ideas for further comparisons with experiments.
A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes
Authors: Perera Marianne R. , Roche Kathryn L. , Murphy Eain A. , Sinclair John H.
Published: January 2022

Long non-coding RNA β2.7 is the most highly transcribed viral gene during latent human cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to β2.7 during HCMV latency. Here we show that β2.7 protects against apoptosis induced by high levels of reactive oxygen species (ROS) in infected monocytes, which routinely support latent HCMV infection. Monocytes infected with a wild-type (WT) virus, but not virus deleted for the β2.7 gene (Δβ2.7), are protected against mitochondrial stress and subsequent apoptosis. Protected monocytes display lower levels of ROS and additionally, stress-induced death in the absence of β2.7 can be reversed by an antioxidant which reduces ROS levels. Furthermore, we show that infection with WT but not Δβ2.7 virus results in strong upregulation of a cellular antioxidant enzyme, superoxide dismutase 2 (SOD2) in CD14+ monocytes. These observations identify a role for the β2.7 viral transcript, the most abundantly expressed viral RNA during latency but for which no latency-associated function has ever been ascribed, and demonstrate a novel way in which HCMV protects infected monocytes from pro-death signals to optimise latent carriage.
Assessing Inequities in COVID-19 Vaccine Roll-Out Strategy Programs: A Cross-Country Study Using a Machine Learning Approach
Authors: Kazemi Mehrdad , Bragazzi Nicola Luigi , Kong Jude Dzevela
Published: January 2022

After the start of the COVID-19 pandemic and its spread across the world, countries have adopted containment measures to stop its transmission, limit fatalities, and relieve hospitals from straining and overwhelming conditions imposed by the virus. Many countries implemented social distancing and lockdown strategies that negatively impacted their economies and the psychological wellbeing of their citizens, even though they contributed to saving lives. Recently approved and available, COVID-19 vaccines can provide a really viable and sustainable option for controlling the pandemic. However, their uptake represents a global challenge due to vaccine hesitancy and logistic–organizational hurdles that have made its distribution stagnant in several developed countries despite several appeals by the media, policy- and decision-makers, and community leaders. Vaccine distribution is also a concern in developing countries, where there is a scarcity of doses. The objective of the present study was to set up a metric to assess vaccination uptake and identify national socio-economic factors influencing this indicator. We conducted a cross-country study. We first estimated the vaccination uptake rate across countries by fitting a logistic model to reported daily case numbers. Using the uptake rate, we estimated the vaccine roll-out index. Next, we used Random Forest, an “off-the-shelf” machine learning algorithm, to study the association between vaccination uptake rate and socio-economic factors. We found that the mean vaccine roll-out index is 0.016 (standard deviation 0.016), with a range between 0.0001 (Haiti) and 0.0829 (Mongolia). The top four factors associated with the vaccine roll-out index are the median per capita income, human development index, percentage of individuals who have used the internet in the last three months, and health expenditure per capita. The still-ongoing COVID-19 pandemic has shed light on the disparity in vaccine adoption across low- and high-income countries, which represents a global public health challenge. We must pave the way for universal access to vaccines and other approved treatments, regardless of demographic structures and underlying health conditions. Income disparity remains, instead, an important cause of vaccine inequity, which restricts the functioning of the global vaccine allocation framework and, thus, the ending of the pandemic. Stronger mechanisms are needed to foster countries’ political willingness to promote vaccine and drug access equity in a globalized society where future pandemics and other global health crises can be anticipated.
Benefits of Using Dapsone in Patients Hospitalized with COVID-19
Authors: Kanwar Badar A. , Khattak Asif , Balentine Jenny , Lee Jong Hoon , Kast Richard E.
Published: January 2022

Since the start of the SARS-CoV-2 pandemic, refractory and relentless hypoxia as a consequence of exuberant lung inflammation and parenchymal damage remains the main cause of death. We have earlier reported results of the addition of dapsone in this population to the standard of care. We now report a further chart review of discharge outcomes among patients hospitalized for COVID-19. The 2 × 2 table analysis showed a lower risk of death or discharge to LTAC (Long term acute care) (RR = 0.52, 95% CI: 0.32 to 0.84) and a higher chance of discharge home (RR = 2.7, 95% CI: 1.2 to 5.9) among patients receiving dapsone compared to those receiving the usual standard of care. A larger, blinded randomized trial should be carried out urgently to determine if dapsone indeed improves outcomes in COVID-19.
A VLP-Based Vaccine Candidate Protects Mice against Japanese Encephalitis Virus Infection
Authors: Yang Limin , Xiao Aibo , Wang Hu , Zhang Xiaojuan , Zhang Yuan , Li Yunlong , Wei Yanqiu , Liu Wenjun , Chen Chuangfu
Published: January 2022

Japanese encephalitis virus (JEV) is the leading cause of epidemic encephalitis in Asia, and vaccination is the most effective way to prevent JE. Although several licensed vaccines were widely used, there is still a demand for developing safer, cheaper, and more effective JE vaccines. In the current study, a virus-like particle (VLP) vaccine candidate containing the envelope structural protein of JEV expressed by the Pichia pastoris was assembled in vitro. It elicited a robust humoral and cellular immune response in mice model, conferring immunodeficient mice complete protection against lethal doses of JEV challenge. Furthermore, pigs immunized with VLP alone without adjuvant via intramuscular produced high neutralizing antibodies against JEV. Consequently, this study showed a new design of JEV subunit vaccine based on VLP strategy and demonstrated the potential for clinical application.
Seven-Year Evolution of β-Lactam Resistance Phenotypes in Escherichia coli Isolated from Young Diarrheic and Septicaemic Calves in Belgium
Authors: Guérin Virginie , Farchi Alban , Thiry Damien , Cawez Frédéric , Mercuri Paola Sandra , Galleni Moreno , Mainil Jacques , Saulmont Marc
Published: January 2022

Antimicrobial resistance is a major worldwide hazard. Therefore, the World Health Organization has proposed a classification of antimicrobials with respect to their importance for human medicine and advised some restriction of their use in veterinary medicine. In Belgium, this regulation has been implemented by a Royal Decree (RD) in 2016, which prohibits carbapenem use and enforces strict restrictions on the use of third- and fourth-generation cephalosporins (3 GC and 4 GC) for food-producing animals. Acquired resistance to β-lactam antibiotics is most frequently mediated by the production of β-lactamases in Gram-negative bacteria. This study follows the resistance to β-lactam antibiotics in Escherichia coli isolated from young diarrheic or septicaemic calves in Belgium over seven calving seasons in order to measure the impact of the RD. Phenotypic resistance to eight β-lactams was assessed by disk diffusion assay and isolates were assigned to four resistance profiles: narrow-spectrum β-lactamases (NSBL); extended-spectrum β-lactamases (ESBL); cephalosporinases (AmpC); and cephalosporinase-like, NSBL with cefoxitin resistance (AmpC-like). No carbapenemase-mediated resistance was detected. Different resistance rates were observed for each profile over the calving seasons. Following the RD, the number of susceptibility tests has increased, the resistance rate to 3 GC/4 GC has markedly decreased, while the observed resistance profiles have changed, with an increase in NSBL profiles in particular.
Feline Uveal Melanoma Review: Our Current Understanding and Recent Research Advances
Authors: Kayes David , Blacklock Benjamin
Published: January 2022

Melanocytic neoplasia is the most common form of ocular tumour in cats, accounting for 67% of cases in an analysis of 2614 cases of primary ocular neoplasia. Feline diffuse iris melanoma (FDIM) is by far the most common form of ocular melanocytic neoplasia, with limbal melanomas and atypical melanoma (melanoma affecting the choroid or ciliary body) infrequently recognised. Early lesions begin as flat areas of pigmentation of the iris, known as iris melanosis. This melanosis is a precursor lesion that can become FDIM when pigmented cells infiltrate the anterior iris stroma, commonly alongside a transition in cell morphology. The differentiation between FDIM and benign iris melanosis is only recognisable though histologic examination, with no in vivo means of identifying the malignant transformation. The behaviour of FDIM is variable and difficult to predict. Some FDIM lesions have a more benign progression and can slowly grow or remain static for years without affecting the ocular or systemic health of the individual, whilst other tumours behave aggressively, invading the ocular structures and significantly affecting the life expectancy of cats through metastatic disease. This makes management and timely enucleation of these cases challenging in practice. This article aims to review our current knowledge of FDIM.
Joint Spatial Modeling of Nutrients and Their Ratio in the Sediments of Lake Balaton (Hungary): A Multivariate Geostatistical Approach
Authors: Szatmári Gábor , Kocsis Mihály , Makó András , Pásztor László , Bakacsi Zsófia
Published: January 2022

Eutrophication, water quality, and environmental status of lakes is a global issue that depends not only on external loadings from industrial, agricultural, and municipal sources but often also on internal loadings from lake sediments. In the latter case, in addition to the quality and quantity of nutrients stored in sediments, their relative content may be an important factor. In the example of Lake Balaton, we jointly modeled the spatial distribution of the nutrients nitrogen (N) and phosphorus (P) and their ratio (i.e., N:P) in the sediments of the lake and then provided spatial predictions at different scales (i.e., point, basin, and entire lake) with the associated uncertainty. Our aim was to illustrate the merits of applying multivariate geostatistics when spatial modeling of more than one variable is targeted at various scales in water ecosystems. Variography confirmed that there is a spatial interdependence between the nutrients. The results revealed that multivariate geostatistics allows this interdependence to be taken into account and exploited to provide coherent and accurate spatial models. Additionally, stochastic realizations, reproducing the joint spatial variability, can be generated that allow providing spatially aggregated predictions with the associated uncertainty at various scales. Our study highlighted that it is worthy of applying multivariate geostatistics in case spatial modeling of two or more variables, which jointly vary in space, is targeted in water ecosystems.
Decreased Photosynthetic Efficiency in Response to Site Translocation and Elevated Temperature Is Mitigated with LPS Exposure in Porites astreoides Symbionts
Authors: Harman Tyler E. , Hauff-Salas Briana , Haslun Joshua A. , Cervino James M. , Strychar Kevin B.
Published: January 2022

Coral reefs have been detrimentally impacted causing health issues due to elevated ocean temperatures as a result of increased greenhouse gases. Extreme temperatures have also exacerbated coral diseases in tropical reef environments. Numerous studies have outlined the impacts of thermal stress and disease on coral organisms, as well as understanding the influence of site-based characteristics on coral physiology. However, few have discussed the interaction of all three. Laboratory out-planting restoration projects have been of importance throughout impacted areas such as the Caribbean and southern Florida in order to increase coral cover in these areas. This study analyzes photosynthetic efficiency of Porites astreoides from the lower Florida Keys after a two-year reciprocal transplant study at inshore (Birthday reef) and offshore (Acer24 reef) sites to understand acclimation capacity of this species. Laboratory experiments subjected these colonies to one of three treatments: control conditions, increases in temperature, and increases in temperature plus exposure to an immune stimulant (lipopolysaccharide (LPS)) to determine their influence on photosynthetic efficiency and how stress events impact these measurements. In addition, this study is a continuation of previous studies from this group. Here, we aim to understand if these results are static or if an acclimation capacity could be found. Overall, we observed site-specific influences from the Acer24 reef site, which had significant decreases in photosynthetic efficiencies in 32 °C treatments compared to Birthday reef colonies. We suggest that high irradiance and lack of an annual recovery period from the Acer24 site exposes these colonies to significant photoinhibition. In addition, we observed significant increases in photosynthetic efficiencies from LPS exposure. We suggest host-derived antioxidants can mitigate the negative impacts of increased thermal stress. Further research is required to understand the full complexity of host immunity and symbiont photosynthetic interactions.
Pilot-Scale Biological Activated Carbon Filtration–Ultrafiltration System for Removing Pharmaceutical and Personal Care Products from River Water
Authors: Wang Qian , Tang Xiaobin , Zeng Weichen , Wang Feng , Gong Weijia , Chen Jingyuan , Wang Jinlong , Li Guibai , Liang Heng
Published: January 2022

Biological activated carbon (BAC) biofilter coupling ultrafiltration (UF) is a promising process for the treatment of river water contaminated by pharmaceutical and personal care products (PPCPs). However, the pilot-scale study should be conducted to reveal the long-term removal performance and the respective contributions of BAC and UF. In this study, a BAC-UF system with treatment capacity of 0.16 m3 h−1 was operated for 130 days. The water quality was analyzed in terms of CODMn, UV254, NH4+-N, and PPCPs. The results showed that both BAC and UF were related to the removal of organic matter (CODMn and UV254), achieving the removals of 56.00% and 55.25%, respectively. Similarly, BAC and UF were both relevant to the removal effects of ammonia nitrogen, nitrite, and nitrate. Moreover, the BAC-UF process was featured with a high efficiency in the removal of PPCPs, and the average removal of total PPCPs reached 47.84%, especially anhydroerythromycin, sulfachloropyridazine, sulfadiazine, trimethoprim, and caffeine. Besides, it was found that the BAC unit played a key role in PPCPs removal and the UF unit also degraded them by the biomass on UF membranes. Therefore, this study proved the removal performance of BAC-UF for treating popular pollutants from river water, and the BAC-UF process in this work can be considered as a feasible method of producing clean drinking water.
Factors of actualization of the regional potential of the tourism and hotel services sector
Authors: Kuznetsova A. I. ] , Narkhova E. N.
Published: January 2022

The problem of the interest of the country’s athletes in domestic tourism is being studied. Based on the materials of expert surveys, a study of the tourist attractiveness of the Perm region was conducted. The factors identified in the process of studying this information indicate the relevance of the development of tourist infrastructure in Russian regions, including the sphere of physical culture and sports. Perm Krai has natural and cultural prerequisites for the successful development of tourist and hotel infrastructure that meets the needs of the sphere of physical culture and sports. The actualization of the region’s potential is appropriate for the popularization of domestic tourism and the formation of the image of Russia as a sports and tourist country.
Prevalence of HBV and HCV Infections in Iranian Blood Donors; An Updated Systematic Review and Meta-Analysis
Authors: Kasraian Leila , Imanieh Mohammad Hossein , Tabrizi Reza , Shahriarirad Reza , Erfani Amirhossein , Hosseini Sahar
Published: January 2022

BACKGROUND Awareness of the prevalence of hepatitis B (HBV) and hepatitis C virus (HCV) infections, as blood transmitted infections, among blood donors can help policymakers improve the guidelines, share experiences, and estimate the blood safety over the country and in the region. We aimed to determine the prevalence of HBV and HCV infection in Iranian blood donors based on the present published literature. METHODS A meta-analysis was carried out based on the results of an electronic literature search in the international and national databases for all articles published until October 2020. We selected studies that had appropriate sampling and valid statistical analysis as well as proper measurement methods. The heterogenic indices of the studies were determined using Cochran’s (Q) and I-square (I2) tests. According to the heterogeneity results, a fixed or random-effects model was implemented to estimate the pooled prevalence of HBV and HCV. Meta-regression was conducted to explore the suspected sources of heterogeneity. RESULTS We included 61 and 58 eligible studies related to HBV and HCV, respectively. The pooled prevalence of HBV was 0.57% (95% confidence interval (CI): 0.47 – 0.67, I2: 99.9%) among the blood donors. The range of prevalence rates of HBV was between 0.10% and 2.34% in different areas of Iran. The pooled prevalence of HCV was 0.22% (95% CI: 0.20 – 0.24, I2: 98.64%) in blood donors, which varied between 0.02% and 1.09% in separate locations. Subgroup and meta-regression analyses revealed that the year of publication, geographical location, and quality of the studies probably generated the heterogeneity. CONCLUSION The prevalence of HBV and HCV decreased steadily in Iranian blood donors during the past two decades. It should be asserted that most of the health policies and safety measures taken in recent years in Iran have been effective and promising.
Are Serum Levels of Nuclear Factor Kappa B and Forkhead Box Protein P3 in Patients with Non-Alcoholic Fatty Liver Disease Related to Severity of Fibrosis?
Authors: Sohrabi Masoudreza , Gholami Ali , Amir Kalali Bahareh , Khoonsari Mahmoodreza , Sahraei Roghieh , Nasiri Toosi Mohsen , Zamani Farhad , Keyvani Hossein
Published: January 2022

BACKGROUND Inflammation has a significant impact on the development and progression of fatty liver diseases.In this study, we aimed to investigate the relation between serum levels of nuclear factor kappa B (NFkB) and Forkhead box protein P3 (FOXP3)with fibrosis severity among patients with non-alcoholic fatty liver disease(NAFLD). METHODS In a prospective study, the patients suspicios of havingfatty liver were enrolled. The exclusion criteria lack of viral hepatitis, autoimmune hepatitis, Wilson’s or other known liver diseases,history of liver or biliary surgery,bariatric surgery, and medications that influence liver metabolism. The participantsunderwent liver fibroscan. According to liver fibrosis, the patients weredivided into two groups; 1)fibrosis less than 7.2 KP,2)advanced NAFLD, fibrosis ≥7.3 KP. A10 cc fasting blood sample was taken from each patient for laboratory assessments.The variables between the two groups were compared using Chi-square or Fisher’s exact test.The independence of cytokines was assessed by a logistic regression test. RESULTS Totally 90 patients were enrolled.The mean age was 42.21 ± 11 years. Of them, 50 and 47 participants were allocated to groups 1 and 2, respectively. In the univariate analysis, we revealed asignificant difference between age, body mass index (BMI), fasting blood glucose, liver enzymes , total cholesterol, andtriglyceride levels. Also, there was a significant difference betweenthe levels of NFKB and FOXP3 in group one compared with group two of the participants,as FOXP3(9.17 ± 10.0 vs. 18.63 ± 12.9; p < 0.001) and NFKB (1.70 ± 1.70; p < 0.01). After excluding the confounding factors, we observed a significant association between fibrosis level and cytokine levels in logistic regression. CONCLUSION Serum levels of NFKB and FOXP3 increased by advancing liver fibrosis in patients with NAFLD.This is an independent association. The identification of intermediary regulatory factors would be necessary.
Information Systems Strategic Planning Using the Ward and Peppard Method
Authors: Triwidayanti  , Zulkarnaen Iskandar
Published: January 2022

The application of information systems that have not been maximized at BPR Centradana Kapuas is due to the unplanned development of an information system that refers to the information system strategic planning document. This study aims to produce a strategic plan of information technology and systems that are appropriate and sustainable, as well as analyzing business areas and making strategic information so that it is easier to determine strategic decisions and can overcome problems that exist in BPR Pancur Banua Khatulistiwa. The research method used in strategic planning of this information system uses the Ward and Peppard Model. The proposed information system strategy planning is based on internal and external business environment analysis as well as IS/IT internal and external environmental analysis through SWOT analysis, SWOT Matrix, Value Chain Analysis, PEST analysis and IS/IT analysis which produces a portfolio for future information system needs.
Website-Based School Information System Design and Evaluation at Sma Negeri 1 Marga Tabanan-Bali
Authors: Yudana I Gusti Putu Hardi , Prapitasari Luh Putu Ayu
Published: January 2022

At the moment SMA Negeri 1 Marga has developed a website which can be accessed anywhere and everywhere, by whomever, including the students and teachers, as well as it is open for public to access. The information, for example, announcement of the school’s activities, students enrollment (PPDB) and so on, can now be done through the Internet. The website can benefit everyone who uses it and can give more accurate information, simple to access yet effective. The aim of this research was to conduct an evaluation of the recently developed website. After it is evaluated, the result of validation and testing phase said that the developed website or school information system is adequate to be used, in which this means that the system is categorized as ‘Good’. It is based on the resulting evaluation from the content expert which was 3.9 (good), design expert 3.8 (good), teachers 4.2 (good), employees 3.7 (good), students 3.8 (good) and public 3.9 (good).
Prediction Of Graduation Time For Students Faculty Of Computer Science Amikom University Yogyakarta Using Naïve Bayes Method
Authors: Syahputra Adhy , Rasyid Rum Mohamad Andri K. , Istiningsih Istiningsih , Surwiyanta Ardi , Djojodibroto Haile Qudrat , Anan Edy
Published: January 2022

The graduation rate on time in college cannot be taken lightly. In many cases, it is found that there is an imbalance in the number of students who enter and who have completed their studies so that there is a high accumulation of the number of students in each batch. It is necessary to know the factors that cause students not to graduate on time. Data classification techniques can be used to predict the timeliness of student graduation. The algorithm used is the Naïve Bayes algorithm with data from 122 students from the Informatics Engineering and Information Systems study program at the Faculty of Computer Science, AMIKOM University, Yogyakarta. Based on the results that have been carried out, it can be concluded that the Naïve Bayes algorithm is applied accurately to predict the timeliness of students' graduation. The results of testing the level of prediction accuracy resulting from the trial reached 90.16%.
المركز القانوني لكفيل الكفيل (المصدق) في القانون العراقي
Authors: علي راقية عبد الجبار
Published: January 2022

كفالة المصدق، عقد بمقتضاه يكفل شخص تنفيذ التزام بأن يتعهد اللدائن بأن يفي بهذا الالتزام إذا لم يف به المدين الأصلي للدين والكفيل الذي تولى ضمان التزامه. فالمصدق، يعد الضامن الثاني للدين بعد الكفيل، إذ أن موضوع التزامه لا ينصب على ضمان دين المدين، وإنما ينصب على ضمان التزام الكفيل ومن هنا يكون للدائن ثلاثة أشخاص مسؤولين عن دين واحد وهم كل من: المدين، الكفيل، المصدق.

يتناول هذا البحث المركز القانوني للمصدق، من حيث التعريف بالمصدق وبيان الشروط الواجب توافره فيه وعلاقته بالدائن. والدفوع التي يستطيع التمسك بها لدفع مطالبة الدائن له بالدين.
El desalojo notarial
Authors: Agurto Moreno Jean Fredy
Published: January 2022

En este trabajo analizamos la Ley n.o 30933, precisamos su propósito y sus alcances sobre la función notarial en los asuntos no contenciosos, y examinamos las atribuciones notariales y la naturaleza no contenciosa del procedimiento originado por la ley. Luego, tratamos su relación con el instituto procesal del desalojo, la potestad activa en este procedimiento y el contrato de arrendamiento conforme a lo que establece la ley. Asimismo, explicamos el procedimiento notarial diseñado para la constatación de las causales de desalojo y, por último, señalamos los aspectos a considerarse respecto de la mencionada ley.
The case for legal technique
Authors: Chiaramonte Xenia
Published: January 2022

In an apparently paradoxical or contradictory way, our new century seems to show two trends: on the one hand, an increasingly informal, disorganized, oftentimes violent spate of uprisings, and on the other hand, a growing exploitation of legal strategies. Given these developments, how do we rethink the relationship between social struggles and law? This article employs a casuistic approach in order to explore current modes of interconnections between law and society. It argues that law is that language that through the institution of norms gives shape to the world of social relations. Through this same language, law performs actions in this world that it institutes through its categories. This piece also proposes a technical understanding of the concept of legal mobilization and argues that the innovative use of legal technique (rather than a political grammar) and the institutions of social cooperation could be seen as elements that re-describe and re-signify legal mobilization.
Barreras comerciales en la importación de productos chinos al Perú
Authors: Huamán-Zevallos Angie Pila , Martínez-Contreras Yorlady Abigail , Macha-Huamán Roberto
Published: January 2022

El artículo de revisión tiene como objetivo analizar las barreras comerciales en la importación de productos chinos al Perú. Con este fin se realizó una revisión de manera sistemática en las bases de datos Ebsco, Proquest, Redalyc, Scielo, Worldwidescience, Google Académico y repositorios de universidades peruanas. Como resultado se muestra que existe una importación masiva de productos hacia el mercado peruano, afectando a las empresas y a los sectores de las diversas industrias. Se concluye que las barreras comerciales protegen la industria nacional de las importaciones, a través de las medidas arancelarias y no arancelarias; las cuales permiten restringir el ingreso de productos que puedan generar efectos negativos en la industria nacional.
Diversificación de la oferta exportable y las exportaciones peruanas
Authors: Yllescas-Rodríguez Patricia Maribel , Espinoza-Casco Roque Juan , Macha-Huamán Roberto
Published: January 2022

RESUMENEl artículo tiene como objetivo analizar la diversificación de la oferta exportable y las exportaciones peruanas. La metodología tomada en cuenta fue la revisión de literatura científica de las bases de datos especializadas; Scopus, Ebsco Host y Redalyc. Los principales resultados indican que los países deben buscar diversificar su oferta exportable y diversificar sus exportaciones por mercados de destino, pasando de una estructura exportadora de productos primarios a una industrialización manufacturera de productos con valor agregado, de esa manera reducir el efecto de vulnerabilidad en términos de intercambio en épocas de crisis y mantener el equilibrio entre las exportaciones y el crecimiento económico. Se concluye que, a pesar de los grandes esfuerzos realizados por países como Perú, Chile y Colombia en materia de política de comercio exterior, continúan siendo dependientes de las exportaciones de productos primarios provenientes del sector minero con escaso valor agregado.
Marketing experiencial para las empresas del sector privado
Authors: Alta-Tierra Luis Antonio , Rivera-Costales José Alberto
Published: January 2022

El marketing experiencial va más allá de colocar productos, valores o servicios y centra sus esfuerzos en demostrar como la oferta de valor de la empresa enriquece la vida del consumidor. El objetivo de esta investigación consiste en presentar un programa de marketing experiencial para la empresa Training Alta Tierra de la ciudad de Riobamba, buscando a través de este los factores que mejoren la captación, enganche y fidelización de clientes. La investigación es de tipo descriptiva con diseño no experimental. Los resultados más sobresalientes muestran que el mercado meta se capacita con una frecuencia trimestral y semestral; así mismo reflejan que, aunque les agrada mucho el servicio brindado, la organización tiene muchos aspectos en los cuales mejorar; y del mismo modo se halló que el medio de comunicación de más alto impacto en el segmento objetivo son las redes sociales.
Balance Scorecard: Estrategia de gestión en el sector de obras civiles
Authors: León-Brabo Darwin Patricio , Tapia-Tapia Mario Enrique
Published: January 2022

La investigación tiene por objetivo determinar los parámetros que influyen y retrasan la adecuada gestión presupuestaria, adicionalmente la determinación de las nuevas variables para el mejoramiento de los índices de atención de requerimientos sin desatender mejoras a nivel de procesos operativos, buscando una mejora en el desempeño del departamento de obras civiles. Mediante metodología descriptiva con diseño no experimental. Se concluye que el crecimiento continuo requiere mayor inversión y planificación por parte del área a de mantenimiento. Adicionalmente se determina en la variable finanzas que el mejor método para comunicación es el sistema GLPI (sistema interno de incidentes) y la comunicación mediante correo electrónico, esto debido a la necesidad de evidenciar la gestión con un respaldo de los requerimientos solicitados.
Resiliencia y desempeño docente en tiempo de pandemia en instituciones educativas de secundaria peruana
Authors: Avila-Valdiviezo Blanca Yaneth , Carbonell-García Carmen Elena , Salas-Sánchez Rosa María
Published: January 2022

La investigación de revisión documental tiene por objetivo analizar la resiliencia y desempeño docente en tiempo de pandemia en instituciones educativas de secundaria peruana. Entre los principales problemas laborales del docente es que labora desde el hogar y debe convivir con los problemas derivados de cada miembro de la familia, siendo importante advertir que emociones negativas como la depresión, soledad, ira, son contraproducentes para el buen desempeño profesional del docente. En consideración, la resiliencia incide favorablemente en la generación de un estado de satisfacción laboral por parte del docente, así mismo, se constituye en un agente protector a factores desencadenantes del estrés, ansiedad, depresión, como elementos adversos a la sanidad mental del profesional de la educación; siendo necesario considerar adaptar el currículo desde una concepción emocional – tecnológica con la finalidad de prever la minimización de situaciones adversas concomitantes a daños emocionales en el docente.
Educación Emocional y Complejidad
Authors: Amaya-Mendoza Eliana Rosa
Published: January 2022

Educación Emocional y Complejidad
Familia y escuela en el Perú
Authors: Sucari Wilson , Aza Patty , Yana Marisol
Published: January 2022

Sobre la participación familiar en la educación escolar, en los últimos años, diferentes investigadores e instituciones han considerado la importancia de su análisis por haberse encontrado beneficios referidos a la mejora integral en el desarrollo de los educandos, la institución educativa, la familia y la sociedad general. En ese contexto, esta investigación, tiene por objetivo general comprehender la situación actual de la participación familiar en la educación escolar peruana, a través de los siguientes objetivos específicos: a) Identificar los responsables de los ministerios y las organizaciones que trabajan en la educación y la participación de las familias; b) Analizar y sistematizar las leyes, políticas o programas acerca de la participación familiar en la educación escolar; c) Explicar las condiciones actuales de participación familiar en la educación escolar en el Perú. Este estudio se basa en la revisión y el análisis de la información en el ámbito de participación familiar a través de la revisión de documentos legales, informes, investigaciones, etc. De esta manera, este estudio, ofrece una sistematización de la información recopilada, a través de un análisis documental de contenido de los temas de estudio. Este trabajo se estructura en tres partes. En la primera parte se presenta el marco metodológico de estudio y el marco conceptual donde se realiza una revisión de la literatura acerca de la conceptualización, los tipos o modelos y los beneficios de la participación familiar en la educación escolar de los hijos. En la segunda parte, se realiza el análisis de las condiciones de la participación familiar en la educación escolar peruana, mediante la revisión de Normas Legales como la Constitución Política, la Ley General de Educación, la Ley de Asociación de Padres de Familia, entre otras. Asimismo, se agrega el estudio de diferentes informes e investigaciones donde se ha materializado la práctica de la participación familiar. En la tercera parte se ofrece una serie de conclusiones y recomendaciones que pueden ser de utilidad para la orientación e implementación de políticas y programas de participación familiar en la educación escolar de los hijos.
OVERVIEW OF THE INNOVATIVE COMPONENT OF NATIONAL ECONOMIC DEVELOPMENT
Authors:   Belgorod State Technological University named after V.G. Shukhov, Zhenpeng X
Published: January 2022

In modern conditions, the identification of innovative development trajectories for many countries, both developed and developing, has become one of the main conditions for economic growth and strategic development. The article presents the results of a study of the innovative potential of China as an undoubted leader in the production and development of science and technology. The national innovation system of China is a kind of" powerful locomotive " of economic transformations in the country. In the course of the conducted research, the specific features of Chinese innovative development are analyzed; the system of management and regulation of innovative activity of the country is studied; attention is paid to the activities of the Ministry of Science and Technology directly related to the formation of the principles and guidelines of the national innovation system of China; the level of expenditures on research and development work is estimated; a comparative analysis of China's positions among other innovative active countries (developed and developing-Israel, South Korea, Sweden, Japan, Germany, the USA, Finland, France, Great Britain, Russia, India) is carried out. The results of the study: an overview of the current state of innovation activity in the country is given (innovative indicators are presented – the number of enterprises engaged in innovative activities in the country, the main income from business in the high-tech industry, the investment intensity of costs for research and development, patent activity); the leading Chinese industries (with the largest corporate expenditures on R & D) and companies (according to the indicator "Issuance of patents") are studied; The key problems of China's innovative national development are identified, among which are: lack of talent and brain drain, excessive spending on innovation, poor awareness of innovation; effective measures to support China's innovation activity are presented.