bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure-based Discovery of Narirutin as a Shikimate kinase Inhibitor with Anti-tubercular Potency
Authors: Sahu Pramod Kumar , Mohapatra Pranab Kishor , Rajani Dhanji Popatbhai , Raval Mukesh Kumar
Published: October 2019

Background:

Shikimate pathway is essential for tubercular bacillus but it is absent in mammals. Therefore, Shikimate kinase and other enzymes in the pathway are potential targets for the development of novel anti-tuberculosis drugs.

Objective:

In the present study, Shikimate kinase is selected as the target for in silico screening of phytochemicals with an aim to discover a novel herbal drug against Mycobacterium tuberculosis (Mtb).

Methods:

A structure-based drug discovery approach is undertaken for the execution of the objective. Virtual screening of phytochemical database NPACT against the target, Shikimate kinase (PDB ID 3BAF), is carried out followed by toxicity and drug-likeness filtration. Finally, a lead, narirutin was selected for in vitro anti-tubercular study.

Results:

Narirutin, present in citrus fruits, emerges as the lead. It is considered to be non-toxic with predicted high LD50 value, 12000 mg/kg body weight. The phytochemical is tested for its antitubercular activity in vitro. It has MIC99 62.5 μg/mL against the MtbH37Rv strain.

Conclusions:

This is the first-ever report to show anti-tuberculosis potency of narirutin.
Uzmanların Pısa ve Tımms Sınavlarının Eğitim Politika ve Programlarına Etkisine İlişkin Görüşleri
Authors: Gürlen Eda , Demirkaya Abdul Samet , Doğan Nuri
Published: October 2019

Araştırmanın amacı uzmanların PISA ve TIMMS
sınavlarına, bu sınavların eğitim politikalarına ve öğretim programlarına
etkisine ilişkin görüşlerini belirlemektir. Araştırma kapsamında PISA ve TIMMS
sınavlarının içeriğine, sorularına, çeviri ve uygulama süreçlerine; ülkelerin
sınavlardaki başarı durumları; sınav sonuçlarının eğitim sistemleri üzerinde
baskı oluşturma durumları ve eğitim politika ve öğretim programlarını etkileme
durumlarına ilişkin akademisyen ve uzmanların görüşleri alınmıştır. Ayrıca katılımcılardan
sonuçlar doğrultusunda alınması gereken önlemlere ilişkin öneriler sunmaları istenmiştir.
Araştırmanın çalışma grubu PISA ve TIMMS sınavları üzerine araştırmaları olan
beş akademisyen ile sınavların uygulama süreçlerinde görev alan beş uzman olmak
üzere, toplam 10 kişiden oluşmaktadır. Araştırma verileri, araştırmacılar
tarafından geliştirilen yarı yapılandırılmış görüşme formu ile elde edilmiştir.
Görüşme formuyla elde edilen veriler içerik analizine tabi tutulmuştur. Araştırma
sonucunda, akademisyen ve uzmanların sınavların içerik ve kapsamının öğretim
programlarına uygun olduğu, sonuçların eğitim sistemlerine ışık tuttuğu fakat
eğitim sistemlerinin başarı durumunu yargılamak için tek başına yeterli
olmadığı ve sonuçların Türk eğitim sistemi üzerinde olumlu yönde bir baskı
oluşturmadığı konusunda büyük oranda fikir birliğinde oldukları belirlenmiştir.
Sınavların çeviri ve adaptasyon süreçlerine, sonuçlardan faydalanma, sınav
sonuçları ile eğitim politikaları arasında ilişki kurma ve sınav sonuçlarının
gelecek eğitim politikalarını etkileme durumuna ilişkin görüş ayrılıkları
olduğu belirlenmiştir.

Anahtar Sözcükler: PISA,
TIMMS, eğitim politikaları, öğretim programı
Origen y distribución de arcillas utilizadas en la fabricación de búcaros: bucarofagia en la Edad Moderna
Authors: Rodríguez María del Pilar García , Álvarez García Beatriz
Published: October 2019

Este artículo tiene como objetivo general estudiar el origen y la distribución de las arcillas utilizadas para fabricar los búcaros que las damas españolas de la Edad Moderna comían, después de haber bebido sus olorosas aguas. Esta costumbre, llamada “bucarofagia”, estaba muy extendida entre la alta sociedad de la época, aunque su origen se remonta al siglo IX. Citada por numerosos autores de la Edad de Oro, está representada en el cuadro Las Meninas de Velázquez. Los tres yacimientos más importantes de los que se extraía la arcilla para fabricar esta cerámica se sitúan en Estremoz (Portugal), Salvatierra de los Barros (Badajoz) y Tonalá (México).  En este trabajo se comparan los tres yacimientos y las características de sus arcillas. Estas arcillas están formadas por montmorillonita, con presencia de ilita, caolinita y minerales de hierro; en menor proporción aparecen cloritas, feldespatos y cuarzo.  En este trabajo se realiza una revisión de los materiales originales que han formado estos yacimientos, caracterizados porque las arcillas provienen de la alteración de minerales muy ricos en hierro, preferentemente pizarras y esquistos. Se analizan sus semejanzas y diferencias con el fin de establecer la posible relación entre la composición mineralógica de las arcillas y su utilización en la fabricación de búcaros.
Modelagem e mapeamento de áreas de perigo de inundação urbana na cidade de Francisco Beltrão (Brasil)
Authors: Farias Ariadne , Mendonça Francisco De Assis
Published: October 2019

A intensificação da urbanização-industrialização brasileira, após a década de 1970, gerou uma considerável degradação ambiental no país com expressivos impactos negativos aos ecossistemas e à população urbana. Diante desse cenário, o sistema hídrico é um dos primeiros a evidenciar os sinais da degradação ambiental nas cidades. Na Região Sul do país a ocorrência de eventos hidrometeorológicos extremos tem gerado preocupação nas instituições públicas e privadas, uma vez que as inundações vêm causando, a cada ano, elevados prejuízos à população, à infraestrutura e aos serviços localizados nas áreas de risco. Nesse contexto, o presente artigo apresenta os procedimentos metodológicos utilizados no mapeamento das áreas de perigo natural de inundação, ou seja, daquelas afetadas pelo espraiamento das cheias dos rios e canais urbanos. O objetivo do estudo foi demonstrar a aplicação das técnicas de modelagem hidrológica e dos recursos da cartografia digital ao estudo de caso das inundações registradas na cidade de Francisco Beltrão, localizada no estado do Paraná.
La construcción de territorialidades del agua en Uruguay. Un enfoque desde la Hidrogeografía
Authors: Domínguez Sandoval Ana Estela , Achkar Borras Marcel
Published: October 2019

Desde la segunda mitad del siglo XX, la Geografía abordó la investigación en agua y recursos hídricos, posteriormente la investigación científica se reorientó hacia la gestión sustentable del agua, convirtiendo a la Geografía en una disciplina relevante en la gestión integrada de cuencas hidrográficas. De esta manera, la Hidrogeografía, (que difiere de la hidrología y de la hidráulica) se consolidó con el objetivo de analizar los territorios y la territorialidad del agua. En este contexto, se establece un debate sobre el agua, centrándolo entre la intersección de los derechos humanos, las reglas del mercado y su totalidad territorial. Este trabajo analiza el caso de Uruguay, donde la privatización del agua fue revertida a través de un proceso de iniciativa ciudadana. A partir de este hecho político se creó un segundo nivel de institucionalidad en la gestión del agua: los Consejos Regionales y Comisiones de Cuenca, de manera participativa, avanzando en la generación de propuestas desde la visión crítica de la Hidrogeografía. En el proceso, se inició una disputa epistemológica entre las condiciones de implementación y se cuestionó la participación social como categoría central de análisis. La Hidrogeografía postula la construcción de un sistema de territorialidades, confrontado las orientaciones clásicas de la hidrología y de la biología, generando una disputa epistemológica en la producción de conocimiento en torno al agua. Posteriormente, se generaron situaciones de tensión para ocupar los espacios institucionales para la toma de decisiones, principalmente con la intención de influir en las políticas públicas.
Precipitación acumulada en las tierras altas entre las secciones Tilarán y Central, Costa Rica
Authors: Quesada Marvin
Published: October 2019

Se analiza el total acumulado de la precipitación cada cinco año, utilizando tres estaciones meteorológicas: Zarcero, Piedades Sur y Montes de Oro en Costa Rica. Estas localidades fueron seleccionadas, ya que cada una se ubica en sectores con distintos niveles de precipitación. De esta manera es posible tener una idea del comportamiento de la precipitación a lo largo de veinte años. Esto debido a que, por ser estaciones ubicadas en sectores muy rurales, solo una de ellas, la primera tiene datos superiores a los cincuenta años, pero para homogenizar los registros se tuvo que considerar solo veinte años. Los periodos históricos cada cinco años secos o húmedos se identifican mediante el método de índice de precipitación estandarizado y sus tendencias se analizan para evaluar la posible relación con el evento ENOS. Todas las estaciones evidencian cierta igualdad en la distribución quinquenal en la precipitación en el transcurso del período de estudio (1994-2013). La tendencia en cada estación es la siguiente, Zarcero, muestran niveles altos en el periodo 2004-2008. En Montes de Oro los niveles de precipitación son muy regulares, aunque con un ligero incremento entre el 2004-2008, pero en realidad es muy leve el incremento. En el caso de Piedades Sur se muestra un fuerte incremento en la lluvia en el quinquenio de 2004-2008. Esto refleja la existencia de una relación entre la precipitación del área en estudio con respecto a evento del ENOS, así como la influencia de la irregularidad en el relieve montañoso.
Descubrimiento y reporte de las primeras estepas altiandinas en Venezuela
Authors: La Marca Enrique , Contreras-Contreras Yocelin B.
Published: October 2019

Se hizo un levantamiento cartográfico y ecológico de un sector semiárido de los Pueblos del Sur de Mérida, en los Andes venezolanos, basado en la aplicación del modelo bioclimático de Zonas de Vida de Holdridge. Se detectaron cuatro zonas de vida para el área de estudio: monte espinoso Premontano, estepa espinosa Montano Bajo, estepa Montano y bosque húmedo Montano. Dos de las formaciones vegetales detectadas, la estepa espinosa Montano Bajo y la estepa Montano, constituyen dos Zonas de Vida que se reportan por primera vez para Venezuela. Las pequeñas dimensiones que éstas ocupan con respecto a la superficie del país y del estado explica en parte el por qué no habían sido detectadas previamente. Las Zonas de Vida de Venezuela ahora ascienden a un total de 24, de las cuales 20 se localizan en el estado Mérida, incluyendo las dos nuevas que son exclusivas de éste. Todas las Zonas de Vida actuales en el área de estudio se caracterizaron desde el punto de vista geográfico. Se hizo una reconstrucción de Zonas de Vida en el área para el Último Máximo de Glaciación, donde se evidenció que las estepas altiandinas venezolanas ocuparon una superficie mayor en el pasado.
ANAIS I CONGRESSO SUL-MINEIRO DE NEOPLASIAS DO TRATO GASTROINTESTINAL Faculdade de Medicina de Itajubá – FMIT, Itajubá, Minas Gerais, Brasil 30 e 31 de agosto de 2019
Authors: DO TRATO GASTROINTESTINAL I CONGRESSO SUL-MINEIRO DE NEOPLASIAS DO
Published: October 2019

O I Congresso Sul-Mineiro de Neoplasias do Trato Gastrointestinal marcou os dias 30 e 31 de agosto deste ano como um evento de alta relevância acadêmica e científica na região. Organizado pela Faculdade de Medicina de Itajubá (FMIT), Universidade do Vale do Sapucaí (UNIVAS) e Universidade José do Rosário Vellano (UNIFENAS), o congresso reuniu cerca de 150 acadêmicos e profissionais da saúde do Sul de Minas e contou com apoio institucional de entidades médicas reconhecidas nacionalmente, como a Sociedade Brasileira de Oncologia Clínica (SBOC) e a Sociedade Brasileira de Cirurgia Oncológica (SBCO). Foram oito palestras e três minicursos oferecidos aos congressistas, todos com conteúdo importantes para formação médica e atualização científica.
Tax and Nontax Incentives in Income Shifting: Evidence from Shadow Insurers
Authors: Hepfer Bradford F. , Wilde Jaron H. , Wilson Ryan J.
Published: October 2019

Using the shadow insurance setting, we study the interplay between tax and nontax incentives in income shifting. Shadow insurance involves intercompany transactions designed to help firms meet regulatory capital requirements. However, prior to the Tax Cuts and Jobs Act of 2017 (TCJA), foreign-owned life insurance firms could save taxes by using shadow insurance to shift U.S. profits to tax havens. Consistent with expectations, we find that while nontax incentives appear to be the dominant factor behind firms' use of shadow insurance, tax considerations also played a role for certain firms. We also find that shadow insurance is associated with lower liquid asset holdings and increased credit risk. Overall, our results suggest that taxes were an important incentive for foreign-owned life insurance firms to use shadow insurance pre-TCJA. Moreover, in this setting, nontax considerations appeared to have motivated U.S.-owned firms' use of tax havens.
Auditing Cloud-Based Blockchain Accounting Systems
Authors: Appelbaum Deniz , Nehmer Robert A.
Published: October 2019

In this research, we often refer to Nakamoto's (2008) seminal paper, “Bitcoin: A Peer-to-Peer Electronic Cash System,” to consider his proposed abstracted characteristics and how auditors could look at companies' transactions interfacing to a private/semi-private blockchain with Nakamoto's general characteristics and address the related audit domain for such transactions. We then take these design requirements for auditors and, using design science research (DSR), we consider the transaction processing and contracting contexts that match those requirements in permissioned blockchains.The blockchains discussed in this paper would typically be business-to-business or business-to-consumer, private or semi-private, and residing in either a private, semi-private, or public cloud. Those blockchains will each have their own design and operational procedures, including validation procedures (the miners). We consider the audit issues of data reliability, data security, and transaction transparency in accounting transactions that lend themselves to a permissioned blockchain as well as other contextual issues.
A Primary Role for α-Cells as Amino Acid Sensors
Authors: Dean E. Danielle
Published: October 2019

Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in diabetes, making glucagon an attractive target for therapeutic intervention. Interrupting glucagon signaling lowers blood glucose but also results in hyperglucagonemia and α-cell hyperplasia. Investigation of the mechanism for α-cell proliferation led to the description of a conserved liver–α-cell axis where glucagon is a critical regulator of amino acid homeostasis. In return, amino acids regulate α-cell function and proliferation. New evidence suggests that dysfunction of the axis in humans may result in the hyperglucagonemia observed in diabetes. This discussion outlines important but often overlooked roles for glucagon that extend beyond glycemia and supports a new role for α-cells as amino acid sensors.
Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study
Authors: Schöttker Ben , Xuan Yang , Gào Xīn , Anusruti Ankita , Brenner Hermann
Published: October 2019

OBJECTIVE

Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results.

RESEARCH DESIGN AND METHODS

We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with type 2 diabetes incidence in 7,828 individuals initially without diabetes from a population-based German cohort study with 14 years of follow-up. Hazard ratios (HRs) (95% CIs) per 1 SD were obtained using multivariable-adjusted Cox proportional hazards regression models.

RESULTS

In the total population, weak but statistically significant associations with type 2 diabetes incidence were observed for OxGua levels (HR [95% CI] per 1 SD 1.05 [1.01; 1.09]) and 8-isoprostane levels (1.04 [1.00; 1.09]). Stratified analyses showed that associations of both biomarkers with type 2 diabetes incidence were absent in the youngest age-group (50–59 years) and strongest in the oldest age-group (65–75 years) of the cohort, with HR of OxGua levels 1.14 (1.05; 1.23) per 1 SD and of 8-isoprostane levels 1.22 (1.02; 1.45) per 1 SD.

CONCLUSIONS

These results from a large cohort study support suggestions that an imbalanced redox system contributes to the development of type 2 diabetes but suggest that this association becomes clinically apparent at older ages only, possibly as a result of reduced cellular repair capacity.
Procesos gerenciales de calidad educativa para el desarrollo colectivo del Liceo Nacional Francisco Bello Pineda
Authors: Reyes Jairo , Lamus-García Tibisay Milena
Published: October 2019

La gestión gerencial en las organizaciones educativas constituye un elemento de formación permanente que tiene por finalidad promover un desarrollo armónico e integral para lograr el éxito, con participación de todos los colectivos que comparten el entorno laboral. El gerente en las instituciones educativas debe tener una especial atención a los fines de garantizar, promover, y planificar, aquellos principios gerenciales más eficientes para contribuir al cumplimiento de la misión y visión en su organización. De tal manera, el gerente de hoy debe mejorar los procesos desplegados en su organización a fin de apropiarse del cumplimiento de las funciones que espera y demanda la sociedad a través de la gestión gerencial. La investigación parte del paradigma, permitiendo describir los hechos tal como se están presentando en la actualidad permitiendo flexibilidad en la aplicación, el método etnográfico propuesto en este proyecto es el etnográfico ajustado a normas que lo oriente y se compruebe la veracidad del trabajo permitiendo descubrir e interpretar los procesos gerenciales que se desarrollan en el Liceo Nacional “Francisco Bello Pineda” conociendo los estilos de vida del grupo de personas que conforman los colectivos en su realidad social la acción comunicativa juega un papel muy importante para llegar a la comprensión y entendimiento referente a los distintos estilos y concepciones de concebir la gerencia y la incidencia en los distintos aspectos del funcionamiento de la institución. Se estudiarán diversas categorías, temas y patrones referidos a la cultura organizacional. La investigación estaré centrada en comprender el significado de los procesos gerenciales, puntos de vista y motivaciones para lograr los objetivos que buscan mejorar el desarrollo integral de la gerencia institucional como elemento primordial del sistema educativo
Editorial
Authors: Portacio Rodríguez Carlos Alberto
Published: October 2019

Editorial
Editorial
Authors: Aldana Zavala Julio Juvenal
Published: October 2019

Editorial
INDIGENOUS RHIZOBACTERIA SCREENING FROM TOMATO TO CONTROL Ralstonia syzigii subsp. indonesiensis AND PROMOTE PLANT GROWTH RATE AND YIELD
Authors: Yanti Yulmira , Hamid Hasmiandy , Reflin Reflin
Published: October 2019

Indigenous rhizobacteria screening from tomato to control Ralstonia syzigii subsp. indonesiensis and promote plant growth rate and yield. Bacterial wilt is the most damaging vascular pathogen on tomato and many other crops in tropical, subtropical and warm temperate areas of the world which limits the production. Rhizobacteria have been concerned as potential biological control agents due to their ability to promote plant growth and health, and their role as antagonists of plant pathogens. The purpose of this research was to screen the best indigenous rhizobacteria (IRB) that able to control bacterial wilt disease and increase growth rate and yield of tomato plant. This research was conducted in 3 stages: (1) Isolation and selection of indigenous rhizobacteria as PGPR on tomato seedlings, consisted of 27 IRB isolates and a control, with triplications; (2) Selection of IRB isolates that control R. syzigii subsp. indonesiensis on tomato plants, which consisted of 8 treatments including 7 IRB and a control with 5 replications; (3) Characterization of IRB isolates ability to promote plant growth (indicated with IAA production & phosphate solubilizing). The variables observed were disease development, growth enhancement and IRB isolate ability to produce IAA and solubilize phosphate. The results showed that all IRB isolates were able to control bacterial wilt disease and increase the growth rate and yield of tomato. IR2.3.5, IR1.3.4 and IR1.4.2 were the best isolates in controlling R. syzigii subsp. indonesiensis and increasing the growth rate and yield by 81.25% and 68.72% respectively. All isolates showed various abilities to produce IAA, however, only isolates IR2.3.5 and IR1.3.4 that had abilities to solubilize phosphate.
Pengembangan Media Pembelajaran Matematika Berupa Kotak Pop-Up untuk Anak Autisme
Authors: Aprilia Eka , Supriadi Nanang
Published: October 2019

This study aims to develop learning media in the form of pop-up boxes that are effective and in accordance with the criteria for autistic children. This type of research used in this research is research and development (Research and Development). In this study using ADDIE research methods, namely Analysis, Design, Development, Implementation, Evaluation. Data collection techniques used were test and non-test instruments, data analysis techniques to calculate the validity of the media, students' responses and the effectiveness of instructional media. Validation in this research is based on the validation of media experts and students to determine the response and effectiveness of the resulting media. The results of validation by media experts are 2.67 with the criteria of "quite valid". The response of students 3.27 with very interesting responses. The results of the effectiveness test with a percentage of 66% with effective criteria. Based on the data obtained shows that learning media is feasible to use and effectively applied in learning
La rehabilitación de la persona después de Wittgenstein y Apel, en Anscombe y Llano. ¿A través de Aristóteles o de nuevo Frege?
Authors: Ortiz de Landázuri Carlos
Published: October 2019

Anscombe y Llano pretendieron definir el constitutivo formal de la persona a partir de las propuestas de Wittgenstein o de éste conjuntamente con Apel. Sin embargo para ello primero tuvieron que evitar las paradojas que se originaron entonces, ya sea recuperando la noción de sujeto intérprete del correspondiente silogismo práctico aristotélico, ya sea revisando el uso que  Wittgenstein y Apel habían hecho de sus respectivas teorías fregeanas del significado. En cualquier caso Anscombe definiría a la persona como un “signo interprete” intencional de ella misma, mientras que Llano añadiría que se trata específicamente de un “signo formal” de naturaleza intencional.
RETRACTED ARTICLE: Numerical Solution of Abel′s Integral Equations using Hermite Wavelet
Authors: Mundewadi R. A. , S Kumbinarasaiah
Published: October 2019

A numerical method is developed for solving the Abel′s integral equations is presented. The method is based upon Hermite wavelet approximations. Hermite wavelet method is then utilized to reduce the Abel′s integral equations into the solution of algebraic equations. Illustrative examples are included to demonstrate the validity, efficiency and applicability of the proposed technique. Algorithm provides high accuracy and compared with other existing methods.
Nonhomogeneous Poisson Process and Compound Poisson Process in the Modelling of Random Processes Related to Road Accidents
Authors: Grabski Franciszek
Published: October 2019

The stochastic processes theory provides concepts and theorems that allow building probabilistic models concerning accidents. So called counting process can be applied for modelling the number of the road, sea and railway accidents in the given time intervals. A crucial role in construction of the models plays a Poisson process and its generalizations. The new theoretical results regarding compound Poisson process are presented in the paper. A nonhomogeneous Poisson process and the corresponding nonhomogeneous compound Poisson process are applied for modelling the road accidents number and number of injured and killed people in the Polish road. To estimate model parameters were used data coming from the annual reports of the Polish police [9, 10]. Constructed models allowed anticipating number of accidents at any time interval with a length of h and the accident consequences. We obtained the expected value of fatalities or injured and the corresponding standard deviation in the given time interval. The statistical distribution of fatalities number in a single accident and statistical distribution of injured people number and also probability distribution of fatalities or injured number in a single accident are computed. It seems that the presented examples explain basic concepts and results discussed in the paper.
The Influence of Changing of Treatment Condition on Surface Roughness Parameter During Turning Process by Wiper Insert
Authors: Labuda Wojciech
Published: October 2019

One of the greatest problems of modern production techniques is the achievement of an appropriate quality at minimal costs and accompanied by the production efficiency increase. Therefore, while designing the production process. The technology used should have a considerable influence on the durability and reliability of machine parts to be produced. During finish treatment, the final dimensions as well as functional properties are imparted to a given element by application of proper treatment type. The engineer has a range of production techniques to choose for the proper surface layer formation. It is crucial to find a suitable solution which will meet the requirements as well as the work conditions of a given machine part. The article presents the results of influence of change of cutting parameters on surface roughness parameter during turning process of stainless steel. A shaft made of 304L stainless steel was used for the research. The chemical composition of steel was measured by Solaris-ccd plus optical spectrometer. The cutting process was carried out on a universal CDS 6250 BX-1000 centre lathes. Measurement of surface roughness was carried out by T8000 profilometer. The turning process was conducted by a cutting tool with Wiper insert. During the turning, the following machining parameters were used: cutting speed Vc [m/min], feed f [mm/rev], cutting depth ap [mm] and additionally changed nose radius r [mm], and tool cutting edge angle ᵪr [°]. The results of measurements of Ra parameter underwent statistic analysis. The calculations were conducted by Statistica software.
Reducing Pollution Levels Generated by Short Sea Shipping. Use of Bayesian Networks to Analyse the Utilization of Liquefied Natural Gas as an Alternative Fuel
Authors: Serrano Beatriz Molina , González Cancelas Nicoleta , Soler Flores Francisco
Published: October 2019

Pollution adjacent to the continent's shores has increased in the last decades, so it has been necessary to establish an energy policy to improve environmental conditions. One of the proposed solution was the search of alternative fuels to the commonly used in Short Sea Shipping to reduce pollution levels in Europe. Studies and researches show that liquefied natural gas could meet the European Union environmental requirements. Even environmental benefits are important; currently there is not significant number of vessels using it as fuel. Moreover, main target of this article is exposing result of a research in which a methodology to establish the most relevant variables in the decision to implement liquefied natural gas in Short Sea Shipping has been development using data mining. A Bayesian network was constructed because this kind of network allows to get graphically the relationships between variables and to determine posteriori values that quantify their contributions to decision-making. Bayesian model has been done using data from some European countries (European Union, Norway and Iceland) and database was generated by 35 variables classified in 5 categories. Main obtained conclusion in this analysis is that variables of transport and international trade and economy and finance are the most relevant in the decision-making process when implementing liquefied natural gas. Even more, it can be stablish that capacity of liquefied natural gas regasification terminals under construction and modal distribution of water cargo transportation continental as the most decisive variables because they are the root nodes in the obtained network.
Comparison of Reduction Systems of Harmful Substances into the Atmosphere in Accordance to Requirements of IMO Tier III
Authors: Czmyr Stanisław , Kaminski Piotr
Published: October 2019

Degradation of the environment is nowadays believed to be the most alarming problem that needs to be solved. Global warming and environmental pollution are predicted to cause a catastrophic chain reaction leading to species extinction, mass emigration due to rising sea levels and global crisis. The only solution suggested by international organizations is the immediate reduction of greenhouse gases and other harmful substances. Marine transportation harmful substances into the atmosphere are recognized to be a significant source of global atmospheric pollution. Despite the high efficiency of marine diesel engines, their impact on the environment is considerable. Due to environmentally friendly policies, modern engines concerns about not only efficiency but also mainly about s aspects. This article analyses and compares marine s exhaust gases reduction methods. Especially the most harmful substances emitted by ships were taken into consideration. The article presents the most crucial law regulations of harmful substances to the atmosphere, pointing at actual and possible future implementations. The most complex methods allowing meeting the latest limits were presented. Pros and cons of available control methods were thoroughly described and methods were compared. The most adequate methods form the effectiveness and economical point of view was pointed out.
Problems of an Aerodynamic Interference between Helicopter Rotor Slipstream and an Elevated Heliport
Authors: Ruchała Paweł , Grabowska Kamila
Published: October 2019

An elevated heliport, as it has been defined by FAA (Federal Aviation Administration), is a heliport located on a rooftop or other elevated structure where the TLOF (touchdown and lift-off area) is at least 30 inches (76 cm) above the surrounding surface [1]. One of greatest advantages of such heliports is that they require less free space, which eases its build nearby existing buildings – especially in densely built-up areas. However, design of such heliports is more complicated, than ground level ones, while one must include an aerodynamic impact of the building below the elevated heliport and surrounding buildings. The aerodynamic interference between the helicopter and the buildings may result with decline of flight safety, due to sudden decrease of thrust (when flying above the edge of building) or because of increased turbulence in windy weather, wake behind surrounding buildings causing sudden gusts etc. Moreover, oscillations of pressure caused by helicopter rotor influence on the building structure also must be taken into account due to increased wear of upper part of the building or devices mounted on its roof (for example, elevator drives). These oscillation may also cause vibrations of building’s structure, which is especially important in case of medical heliports – which are a vast majority of elevated heliports (and heliports in general) – because of strict requirements for acceptable vibration level. The article is aimed on summarize aerodynamic issues, which should be taken into account during design of elevated heliport.
Research the Possibility of Obtaining Diagnostic Information about the Ships Engine Fuel Injection System Condition based on the Analysis of Characteristics of Heat Release
Authors: Witkowski Kazimierz
Published: October 2019

Marine engines are very complex technical objects, having many important functional systems, which include, inter alia, injection system, characterized by high unreliability. In this system, there may be different types of defects (damage) that affect the engine parameters, including specific fuel consumption, as well as failures endanger the safety of the ship. The indicator diagrams and analysis of indicated parameters have limited utility in the diagnosis of damages of marine engine, although this is a method commonly used in operational practice. To achieve greater diagnostic effectiveness, when, based on indicator diagrams, are calculated and then the characteristics of heat release is analysed - net of heat release characteristics and the intensity of the heat release, it was demonstrated. This procedure is particularly effective in the diagnosis of damages of marine diesel engine injection system components. It has been shown that the characteristics of heat release contain information about the condition of the injection systems, which enable to diagnose their failures. This is shown on the example of a clogged nozzle holes (their carbonizations). The obtained results allowed selecting the diagnosis symptoms, useful in detecting these faults in the injection system, from the characteristics of heat release: net heat release (Q) and intensity of heat release (q). The object of the research was typical marine medium speed engine Sulzer A25/30.
A Prototype Test Stand for Testing Insolated Rotor Systems
Authors: Wojtas Małgorzata , Czajkowski Łukasz
Published: October 2019

The article discusses assumptions for a prototype test stand designed for testing rotors in the conditions of work at their nominal speed, in particular gyrocopter and helicopter rotors. In the work presents an overview of similar solutions of test stand presented in the available literature and solutions proposed by companies, such as Swangate International or Luftfahrttechnik GmbH. Beyond these solutions the article also contains test stand used so far at the Institute of Aviation, these solutions were prepared for testing one type of rotor (for example: only for gyroplane rotors). The article provides the steps of designing a new test stand, which one of the basic assumptions is that it will be a universal test stand, giving the possibility to test different types of rotors. The article discusses two concepts of the stand with electric engine as a drive, gives the advantages and disadvantages of each concept, and indicates the selected solution. In addition to design and applied drive solution of the stand, the measuring part and data acquisition were also discussed. Moreover, the article focus on the advantages of rotor testing using the presented solution, as well as problems encountered during tests, in particular related to construction free vibrations and resonance. Vibration and resonance of the test stand are very important aspect of the entire design process, because it affects the quality and safety of the tests.
HUBUNGAN INFORMASI TENTANG ALAT KONTRASEPSI DENGAN MOTIVASI PEMILIHAN ALAT KONTRASEPSI IMPLANT DI DESA POREH WILAYAH KERJA UPT. PUSKESMAS LENTENG KEC. LENTENG KAB. SUMENEP
Authors: Nurhidayati Eva , Permatasari Dian
Published: October 2019

The family planning program (KB), which has been running for 40 years, is able to preventa population increase of about 100 million people. BKKBN expects this year to increase theknowledge and skills of acceptor families. Namely about parenting and child development anddevelopment. In addition, improving the quality of elderly families, as well as the family's economicincome through the group of productive economic business activities. To know Information AboutRelationship With Contraceptive Implant Contraceptive Selection Motivation.The study design used is an analytical method with cross sectional design.The population inthis study as many as 633 large maternal EFA and EFA sample40 mothers. Engineering samplesare used random sampling. The data got fromthe village of the District Poreh Lanteng andquestionnaire data analysis while using the Spearman rank correlation test.The results showed the majority (62.5%) mothers receive less information, the majority(70.0%) mothers had a negative motivation in Contraceptive Implant Selection. Statisticalresearch results obtained using the Spearman rank correlation test Relationship WithInformation About Contraception Contraceptive Implant Selection Motivation in can sig ρ = 0.000<α = 0.05) so that H0 is rejected, which means there is the Relationship Between InformationAbout Motivation Election With Contraceptives Contraception.The conclusion of this study is the lack of information that pussy mother and motivationthat can negatively affect the Selection Tool contraceptives.
PERILAKU PASIEN HIPERTENSI DALAM PENCEGAHAN KOMPLIKASI DI DESA SAMATAN WILAYAH KERJA PUSKESMAS PROPPO PAMEKASAN
Authors: Kurniawan Moh Riski
Published: October 2019

Terjadinya komplikasi hipertensi dikarenakan perilaku pasien hipertensi dalam bersikaptidak sesuai dengan anjuran diet hipertensi, makan makanan berkolesterol dan berlemak, seringkonsumsi rokok serta kurang minatnya pasien hipertensi dalam menggali informasi tentangpenyakit hipertensi. Tujuan penelitian ini adalah untuk mengetahui perilaku pasien hipertensiDesain penelitian yang di gunakan adalah deskriptif. Populasi dan sampel adalah semuapasien hipertensi di Desa Samatan Wilayah Kerja Puskesmas Proppo Kabupaten Pamekasan yaitusebanyak 44 orang dengan teknik sampling yang di gunakan Probability tipe random sampling.Alat ukur yang di gunakan ceklis wawancara, Pengolahan data melalui proses Editing, Coding,Scoring dan Tabulating dengan analis deskriptif (persentase) dan hasilnya bentuk tabel dan narasiBerdasarkan hasil penelitian ini di dapatkan bahwa sebagian besar (57%) responden perilakupencegahan komplikasi kurang sebanyak 25 responden dan sebagian kecil (11%) respondenperilaku baik pencegahan komplikasi sebanyak 5 respondenPerilaku pasien hipertensi di pengaruhi oleh kurangnya peran aktif perawat atau petugaskesehatan sebagai pendidik dengan memberikan HE untuk meningkatkan perilaku yang lebih baikdan sehat.
ANALISIS FAKTOR YANG MEMPENGARUHI PEMBERIAN MAKANAN PENDAMPING ASI (MP-ASI) PADA BAYI (0-6 Bulan) DI DESA PADEMAWU BARAT KABUPATEN PAMEKASAN
Authors: Izzaty Chairatul
Published: October 2019

Makanan dan minuman bergizi yang diberikan pada anak usia 6-24 bulan dalam mencukupikebutuhan gizinya adalah Makanan pendamping ASI (MP-ASI). Ibu memberikan MP-ASI sebelumusia 6 bulan karena ibu menganggap bayi tidak akan tumbuh dan berkembang secara optimal jikahanya diberikan ASI.Desain penelitian ini adalah deskriptif dengan populasi semua ibu yang mempunyai anakusia 0-6 bulan berjumlah 50 orang. Sampel penelitian yaitu sebagian ibu yang mempunyai anak usia0-6 bulan sebanyak 41 orang dengan teknik Simple Random Sampling.Hasil penelititan yang diperoleh diketahui bahwa hampir setengahnya (46%) persepsiresponden dalam pemberian makanan pendamping ASI kurang, pengetahuan responden sebagianbesar (66%) kurang, dan hampir setengahnya (49%) pengalaman responden dalam pemberianmakanan pendamping ASI kurang.Berdasarkan hasil penelitian, maka dapat diambil kesimpulanbahwa persepsi, pengetahuandan pengalaman dalam memberikan makanan pendamping ASI (MP-ASI) pada bayi sebagian besarkurang sehingga ibu perlu menambah pengetahuan dan lebih banyak mencari informasi pemberian(MP-ASI) pada bayi agar waktu pemberian benar dan tepat sehingga bayi dapat tumbuh danberkembang dengan baik dan tidak terjadi dampak negatif pada bayi.
Fault slippage and its permeability evolution during supercritical CO2 fracturing in layered formation
Authors: Wei Xiaochen , Zhang Jingxuan , Li Qi , Liu Xiangjun , Liang Lixi , Ran Lili
Published: October 2019

Understanding the hydromechanical responses of faults during supercritical CO2 fracturing is important for reservoir management and the design of energy extraction systems. As small faults are widespread in Chang 7 member of the Yanchang Formation, Ordos Basin, China, supercritical CO2 fracturing operation has the potential to reactive these undetected small faults and leads to unfavorable fracking fluid migrate. In this work, we examined the role of fault slippage and permeability evolution along a small fault connecting the pay zone and the confining formation during the whole process of fracturing and production. A coupled hydromechanical model conceptualized from actual engineering results was introduced to address the main concerns of this work, including, (1) whether the existence of a undetected small fault would effectively constrain the hydraulic fracture height evolution, (2) what the magnitude of the induced microseismic events would be and (3) whether the permeability change along the fault plane would affect the vertical conductivity of the confining formation and thus increase the risk for the fracturing fluid to leak. Our results have shown that the initial hydrofracture formed at the perforation and propagated upward, once it merged with the fault surface, the existence of an undetected small fault would effectively constrain the hydraulic fracture height evolution. As fracturing continued, further slippage spread from the permeability increase zone of high permeability to shallower levels, and the extent of this zone was dependent on the magnitude of the fault slippage. At the end of extraction, the slip velocity decreases gradually to zero and the fault slippage finally reaches stabilization. In general, undetected small faults in targeted reservoir may not be the source of large earthquakes. The induced microseismic events could be considered as the sources of acoustic emission events detected while monitoring the fracturing fluid front. Due to the limited fault slippage and lower initial permeability, the CO2 fracturing operation near undetected small faults could not conduct preferential pathway for upward CO2 leakage or contaminate overlying shallower potable aquifers.
Arbovírus circulantes no Brasil: fatores associados com a disseminação e estratégias terapêuticas
Authors: Ossa Diana Patricia Santander , Melo Hellen Pereira , Arouca Kalliny Luiza Dias , Baldoino Fabbio Ronnyel Rodrigues , Oliveira Engel Meneses de , Silva Vanessa Poleana , Lopes Priscila Favoritto , De Andrade Ana Rachel Oliveira , Garcês Tereza Cristina de Carvalho Souza
Published: October 2019

Objetivo: Analisar a emergência dos arbovírus e os fatores que contribuem para a disseminação e infecção, bem como possíveis estratégias terapêuticas que auxiliam na condução desses casos. Método: Tratou-se de uma revisão sistemática realizada na Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); no Medical Literature Analysis and Retrieval System Online (MEDLINE) e no Scientifc Eletronic Library Online (SCIELO), por meio de pesquisas nacionais e internacionais no período de 2009 a 2019. Resultados: os fatores responsáveis pela disseminação e infecção são: ausência de vacinas aprovadas ou drogas antivirais específicas, presença de comorbidade, ação antrópica indiscriminada, desordenado crescimento populacional, falta de notificação e acompanhamento, demora no diagnóstico, escolaridade e a situação profissional. Como estratégias de intervenção: o Inibidor da quimiotripsina- tripsina (LsCTI), a necessidade dos médicos e outros profissionais de saúde estarem cientes que infecções por DENV-4 podem ser fatais, o acompanhamento sistemático da população, as ações educativas regulares, o combate ao vetor e o plano de cuidados adequados. Considerações finais: A emergência dos arbovírus interliga os vetores com a ausência de recursos apropriados para a sua prevenção e tratamento.
“Se tem batimento, tem vida”: vivências em torno da hospitalização na visão de familiares de pacientes internados no CTI
Authors: Dos Reis Ewerton Beckman , Branco João Eduardo Barros , Silva Chiara Silmara Santos , Torres Rafael Santana Costa , Borges João Otávio Pinheiro , Moraes Alice Dayenne , Barbosa Jessica Soares , Vasconcelos Esleane Vilela
Published: October 2019

Objetivo: relatar as vivências de familiares como acompanhante de um paciente internado no Centro de Terapia Intensiva e analisar suas implicações para a enfermagem. Métodos: trabalho tipo descritivo, com abordagem qualitativa. Coleta de dados feita por entrevista utilizando roteiro semiestruturado contendo perguntas abertas e questionário socioeconômico. Amostra composta por 20 familiares de pacientes internados no CTI do Hospital Universitário João de Barros Barreto, em Belém-Pará. Foi escolhida a análise de conteúdo temática para elaboração das unidades. Resultados: o perfil da maioria dos familiares da pesquisa foi de mulheres, solteiras, católicas, entre a faixa etária de 20-30 anos com ensino médio completo e pertencentes majoritariamente ao grau de parentesco natural. Analisamos os resultados com base na repetição de termos e significados nas falas dos familiares. Dos significados surgiram duas categorias para o estudo: Compreensão do CTI e repercussões emocionais para os familiares e O núcleo familiar durante a hospitalização. Conclusão: entender os anseios do acompanhante de forma singular e como componente de família é estabelecer atitude profissional visando à integralidade do serviço.
Adesão à higiene das mãos antes e após intervenções educativas do dia mundial para higienização das mãos em um hospital universitário
Authors: De Farias Maria Eduarda Leão , Gonçalves Jefferson da Silva , De Jesus Isac Silva
Published: October 2019

Objetivo: Analisar os efeitos das ações educativas sobre adesão dos profissionais da saúde à higienização das mãos, em hospital universitário. Métodos: Pesquisa descritiva-documental, a partir de levantamento de dados do Serviço de Controle das Infecções Relacionadas à Assistência à Saúde, sobre a adesão à higiene das mãos de janeiro a agosto de 2018. Resultados: Foram analisadas 1371 oportunidades nas unidades de internação do hospital. Realizada uma comparação dos registros de observação direta da adesão à higiene das mãos, considerando as oportunidades nas quais os profissionais de saúde utilizaram água e sabão ou álcool gel a 70% ou não aderiram à prática de higienização das mãos. A maioria dos profissionais não higienizou as mãos no momento indicado (χ2 = 14,544; p valor = 0,0423). O comportamento dos mesmos não mudou, tendo se mantido o hábito de não higienizar as mãos nos cinco momentos básicos (χ2 = 4,933; p valor = 0,1768). Conclusão: Torna-se imprescindível reforçar a prática de higiene das mãos nos serviços de saúde, na tentativa de mudar a cultura prevalente entre os profissionais de saúde, como também o desenvolvimento de metodologias que possam resultar no aumento da adesão dos profissionais de saúde às práticas de higienização das mãos.
Treinarte: a educação em saúde para segurança do paciente
Authors: Pinheiro Leisson Domingues , Farias Dilton Luis Soares de , Marceliano Nunes Ana Carolina , Marques Adhara Belo , Filho Rubervaldo Cruz Sarmento , Neves Wanderson Carvalho , Nascimento Paulo Ricardo Silva do , Valenzuela Reyes Paola Alejandra
Published: October 2019

Objetivo: Relatar os benefícios de orientar, por meio da arte e refletir sobre a contribuição desta estratégia de educação em saúde com foco na segurança do paciente. Relato de Experiência: Este estudo constitui um relato de experiência de caráter descritivo de um Centro integrado de Inclusão e Reabilitação do estado do Pará em relação a execução das práticas organizacionais obrigatórias relacionado a segurança do paciente. A metodologia criou um caminho natural para a avaliação mediadora para maior atenção da equipe para absorção do conteúdo. Considerações Finais: O Treinarte interfere na rotina das pessoas que frequentam o Centro, sejam colaboradores ou usuários do Sistema Único de Saúde, todos são alcançados direta ou indiretamente, pois tal experiência não passa desapercebida.