bluuebunny/crossref_metadata_2025 huggingface dataset:
Santykis su atliekomis žiedinėje ekonomikoje: rūpesčio etikos perspektyva
Authors: Bartkienė Aistė , Bikauskaitė Renata , Mincytė Diana
Published: October 2024

This article examines the ethical dimension of waste management within the context of the circular economy. The authors argue for a shift in focus from technological and practical issues in waste management to a more holistic consideration of the ontological and ethical aspects of waste. By building on the ethics of care perspective, the article proposes a relational approach which prioritizes attentiveness, responsibility, competence, responsiveness, and involvement in addressing waste issues. By examining the five stages of care within the ethics of care framework, the study shows how ethical considerations can inform individual and collective actions within the paradigm of the circular economy. Ultimately, the article reconceptualizes waste as an integral part of our moral and ethical landscape by highlighting relationships embedded in care across private, domestic, institutional, and public domains.
Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Dronko L. M. , Lutsenko T. M. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv;, Korotkevych N. V. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Vovk I. O. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Zhukova D. A. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Romaniuk S. I. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Siromolot A. A. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Labyntsev A. J. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Kolybo D. V. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: October 2024

The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When the precursor is cleaved by metalloproteinases, a soluble form (sHB-EGF) is formed that can bind to the EGF receptors, resulting in activation of signaling pathways that regulate cell proliferation, differentiation, migration, and inhibition of apoptosis. The ability of HB-EGF to cause both positive and negative consequences for organism underscores the complexity of its biological functions and the need for a nuanced understanding of its role in health and disease. In this review the data on the HB-EGF structure, biological activity, involvement in the mechanism of diphtheria toxin action, wound healing, tumor progression as well as the methods of HB-EGF delivery are summarized. Keywords: cell proliferation, diphtheria toxin, EGF receptor, heparin-binding EGF-like growth factor, signal transduction, wound healing
Indices of carbohydrate metabolism and antioxidant system state during germination of aged wheat and triticale seeds treated with H(2)S donor
Authors:   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv, Yastreb T. O. , Kokorev A. I. ,   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv;, Dyachenko A. I. ,   nstitute of Cell Biology and Genetic Engineering, National Academy of Sciences of Ukraine, Kyiv, Ukraine;, Shevchenko M. V. ,   State Biotechnological University, Kharkiv, Ukraine;, Marenych M. M. ,   Poltava State Agrarian University, Poltava, Ukraine;, Kolupaev Yu. E. ,   Yuriev Plant Production Institute, National Academy of Agrarian Sciences of Ukraine, Kharkiv;,   Poltava State Agrarian University, Poltava, Ukraine;
Published: October 2024

Hydrogen sulfide is a gasotransmitter molecule involved in the realization of many functions of the plant organism, including seed germination. Aging of seeds is shown to be accompanied by oxidative stress and reduced germination. The effect of exogenous hydrogen sulfide on the germination of aged cereal seeds has not been studied. The aim of the work was to estimate the effect of priming with NaHS as an H2S donor on wheat and triticale seeds previously subjected to natural aging. Seeds of winter wheat (Triticum aestivum) and winter ×Triticosecale were stored indoors for 4 years at fluctuating temperature and humidity. Aged seeds were treated with 0.2-5 mM NaHS solution for 3 h and germinated in Petri dishes for 3 days. The hydropriming­ treatment was used as a control. Amylase activity in grains, the biomass of shoots and roots, the content of total sugars, H2O2, lipid peroxidation products and anthocyanin, and the activity of antioxidant enzymes in seedlings were determined. It was shown that after the treatment with H2S donor, the activities of catalase and guaiacol peroxidase, as well as the content of anthocyanins were increased only in triticale seedlings. Nevertheless, treatment of seeds of both cereal species was followed by enhanced growth of shoots and roots, increase in amylase and superoxide dismutase activities, decrease in H2O2 and MDA contents, and elevated accumulation of sugars in shoots. It is concluded that the increase in germination of aged cereal seeds under the influence of H2S donor is caused by increased mobilization of reserve carbohydrates and modulation of antioxidant system activity. Such treatment can be considered as an effective tool to improve seedling growth. Keywords: amylase, antioxidant system, hydrogen sulfide, oxidative stress, seeds aging, total sugar, Triticosecale, Triticum aestivum
Short-term reduction in feed intake by dairy cows in the postpartum period leads to subclinical ketosis development
Authors:   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine, Vlizlo V. ,   Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, Lviv, Ukraine;, Stasiv O. ,   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine;, Sedilo H. ,   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine;, Fedak N. ,   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine;, Petryshyn M. ,   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine;, Voloshyn R. ,   Institute of Agriculture of Carpathian Region the National Academy of Agrarian Sciences of Ukraine, Obroshyne Lviv district of Lviv region, Ukraine;
Published: October 2024

Subclinical ketosis is widespread in highly productive dairy cows after calving and often remains undiagnosed, leading to reduced productivity. Physiologically controlled feeding in the first weeks after calving and during the intensive lactation period can reduce the incidence of ketosis. The study aimed to determine how a short-term reduction of feed after calving affects the formation of ketone bodies in blood, urine and milk of dairy cows. The group of ten Ukrainian black-spotted dairy breed cows after calving aged from 4 to 6 years was involved in the experiment lasted for 72 h. In 24 h the amount of compound feed, haylage, and silage received by cows was gradually reduced until complete exclusion in the diet. Blood, urine, and milk samples were collected three times a day. The content of ketone bodies, β-hydroxybutyrate and glucose was estimated with the corresponding sets of indicator strips. The content of total bilirubin, cholesterol, albumin and enzymes activity in the blood serum were determined on biochemical analyzer. It was found that in 24 h after the beginning of feed reduction the level of blood glucose decreased, persistent hypoglycemia within 48 and 72 h was developed, the concentration of β-hydroxybutyrate in blood and milk and of ketone bodies in urine was elevated. The increase in total bilirubin concentration and liver enzymes activity in the blood serum with a simultaneous decrease in albumin level and delayed sodium propionate conversion into glucose were observed. Thus, short-term reduction in feed intake by dairy cows after calving causes ketosis development and violation of liver functions. Keywords: dairy сows, feeding level, glucose, ketosis, liver damage, β-hydroxybutyrate
Case Study Using Artificial Intelligence Broadcasters for Broadcasting Programs on Radio Mustang Jakarta
Authors: Harliantara Harliantara
Published: October 2024

The research focuses on how the use of artificial intelligence (AI) radio broadcaster applications in broadcasting programs that have penetrated the radio business market. This study uses a qualitative method with a case study approach that studies the use of AI radio broadcasters used by traditional media of radio stations. The study examines from various perspectives such as the development of information and communication technology, the innovation of radio programming, the use and process of AI technology in radio, as well as the impact on the radio business of the digital age. Nowadays innovative technologies and distribution methods are beginning to emerge that have a profound effect on how to listen and view radio broadcasts through the internet media. It is for the revolution of radio stations with new opportunities, but also new challenges in addition to conventional radio services available, now available AI technology that has a wide spectrum.
Innovative Educational Broadcasting: UGTV's Influence on Gunadarma Students and the Wider Community
Authors: Prihantoro Edy , Ohorella Noviawan Rasyid , Pitchan Muhammad Adnan , Ferdinand Nikolas
Published: October 2024

Television remains a medium for delivering information and entertainment, to communities, particularly in areas with unequal access to the internet, so television becomes their primary source. This study aimed to explore how UGTV is utilized to deliver educational content to students of Gunadarma University and the wider community. Using a qualitative method with a constructivist paradigm, this study was grounded in the Media Ecology Theory. Data were collected through observation, in-depth interviews, documentation, and literature studies. The findings revealed that UGTV, as an educational digital television platform, effectively provides academic and innovative content useful for the community, particularly students. The contents are produced and packaged to be informative and appealing to the community.
The Religious Conversion of Iranian Asylum-Seeking Women in the Process of Searching for Identity
Authors: Mozafarian Rayehe , Güllüpınar Fuat
Published: October 2024

This article explores the experiences of Iranian women who converted from Islam to Christianity, particularly focusing on the challenges they faced in their home country and as immigrants. Following the 1979 Iranian revolution, women, especially those from minority groups, endured significant oppression. Many women fled Iran in pursuit of freedom, but their difficulties persisted as immigrants, now compounded by their minority status in a new context. Based on qualitative research, including in-depth interviews with twenty-seven women in Eskisehir, Turkey, the study uncovers how patriarchal norms, domestic abuse, early marriage, and a lack of educational opportunities in Iran pushed these women toward Christianity, which offered them not only a new faith but also a sense of personal and spiritual autonomy. The research highlights the complex interplay of identity, religion, and agency, demonstrating how these women's conversions were both an act of defiance against oppressive systems and a path toward personal liberation.
Some of the Understudied Dimensions of Ritual
Authors: Purzycki Benjamin Grant
Published: October 2024

Ritual: How Seemingly Senseless Acts Make Life Worth Living by Dimitris Xygalatas offers a popularized accounting of an adaptationist view of ritual. By highlighting the author’s own work on the topic, the text itself primarily addresses questions of public rituals’ often extreme costs and its relationship to cooperation. This emphasis, though, comes at the expense of other interesting and/or downstream aspects of ritual that, in my view, deserve more attention. In this commentary, I address a handful of the most relevant to the target text, namely: 1) religious vs. secular rituals; 2) the spatio-temporal distribution of ritual; 3) ritual frequency and timing; 4) the demographic structuring of ritual; 5) ritual’s complicated relationship to control and chance; and 6) ritual as a significant generator of meaningful models about the world.
An Overview of Dimitris Xygalatas’ Ritual: How Seemingly Senseless Acts Make Life Worth Living (2022)
Authors: Kiper Jordan , Mauro Nick
Published: October 2024

In his latest book Ritual: How Seemingly Senseless Acts Make Life Worth Living (2021), Dimitris Xygalatas brings together his various research programs with colleagues and the history of ritual theory to explain why humans engage in apparently pointless rituals. His core thesis is that rituals are not pointless activities whatsoever but rather cultural technologies that make our lives better, whether they assuage anxieties or render our communities more prosocial. Drawing from an interdisciplinary body of scholarship, Xygalatas offers a compelling argument as to why we humans are a ritual species. Furthermore, Xygalatas’ extensive laboratory and ethnographic research from over the last two decades provides strong empirical evidence for his thesis and other longstanding theories in ritual studies. The result is a book that delivers a captivating introduction to ritual studies, reasons for seriously considering the power of rituals, and how to research rituals with philosophical rigor and methodological precision.
Seemingly Senseless Acts
Authors: Stagnaro Michael Nicholas
Published: October 2024

In the book Ritual: How Seemingly Senseless Acts Make Life Worth Living, Dimitris Xygalatas walks the reader through what the social/cognitive sciences can teach us about the underlying function of ritual, and why it has persisted as an enduring feature of the human species. This thoughtful book covers a wide range of topics but mostly stays quiet on providing the reader with some understanding of what predicts ritual practice within communities. In this paper, we take the insights provided by Xygalatas throughout the book and attempt to construct several categories based on the core functions that ritual provides. Then, using a nationally representative sample of 1,000 U.S. participants, we attempt to test several of the predictions that come out of the book, finding support for some claims, while finding little to none for others.
Ritual Explained?
Authors: Cigán Jakub , Krátký Jan , Kundt Radek , Kundtová Klocová Eva , Lang Martin , Maňo Peter
Published: October 2024

This commentary highlights the important contributions of the target book to the cognitive and evolutionary study of religion and identifies several issues and challenges that should be addressed in future work. The crucial challenges pertain to the need for more thorough theoretical modeling of what religious beliefs add to the effects of ritual behavior, the need for longitudinal studies of mundane but frequently performed individual rituals, and the need for translating the results of basic research on rituals into applied outputs. We describe those challenges in detail and suggest potential remedies and future directions.
Evacuation of the Leningrad Mint to Krasnokamsk
Authors: Elena Girko , Tatyana Semakina
Published: October 2024

The evacuation of the Leningrad Mint to Krasnokamsk during the Great Patriotic War remains a relatively little-studied episode in the history of the enterprises’ evacuation to the Molotov Region. This is due both to the relatively recent declassification of the enterprise documentation and to the weak interest of researchers in this issue. The work of the Krasnokamsk Museum of Local Lore with documents from Perm and St. Petersburg archives allows us to conclude that the evacuation of the Leningrad Mint to the Urals and the organization of the awards production in Krasnokamsk were complex and difficult processes. The issuance of awards during the Great Patriotic War required the efforts of the enterprise's employees in conditions of a lack of production space, qualified labor, raw materials, and tools. One of the most important problems throughout the entire period of the enterprise operation in Krasnokamsk was the low qualifications of young workers, who often made mistakes in their work. Despite the difficult production conditions, the constantly growing plan, changes in technical parameters and the nomenclature of orders, the enterprise constantly increased labor productivity, became the winner of social competition, and introduced innovations – in particular, it switched to stamping complex awards. The result of the heroic work of the enterprise in Krasnokamsk was the production of more than 2.5 million finished orders and medals, more than 9 million semi-finished award products, more than 10 million copies of special products, as well as about 750 million coins of various denominations and 78 types of award products that appeared during the Great Patriotic War.
Evacuation of Enterprises to Molotov (Perm) during the Great Patriotic War
Authors: Michael Nechayev
Published: October 2024

It is still an impossible task for domestic historiography to describe all aspects of such a large-scale relocation of over half of technical and technological resources as well as a third of the population of the Soviet Union from the West to the East of the country during the Great Patriotic War. The illusion of this topic’s "completeness" was dispelled by the inclusion of previously inaccessible documentary sources. An after-effect of evacuation was the development of the Eastern regions of the country, which served as a background for the economic base of the Soviet Union that, among other things, won an economic victory over the Nazi Germany. General papers devoted to evacuation pay a great attention to the Urals, but many important particulars connected with the Molotov Region (Perm Krai at present) and especially with Molotov City (Perm at present) have not often been the subject of close attention of researchers. The article attempts to systematically reconstruct the picture of evacuation to Molotov (Perm) which was a major destination point in relocation of enterprises, institutions, population, and cultural treasures in 1941-1942. Based on the analysis of new documentary sources, the paper elaborates both on the process of enterprise evacuation and the effects of new manufacturing capacities for the development of the military-industrial complex of the Soviet Union taking Molotov, an important industrial center, as an example. Thorough reconstruction of the evacuation process to Molotov has opened new unfamiliar pages of evacuation history during the Great Patriotic War.
M.A. Dlugach – A Forgotten General of Industry
Authors: Andrei Ryabkov
Published: October 2024

Moses Abramovich Dlugach is one of those wartime leaders who are called Generals of Industry: a metallurgical engineer, director of the largest machine-building enterprises, and a highranking party organizer. Despite the bright mark left by M.A. Dlugach in Leningrad (1940-42) and the Urals (1943), the available information about his career is very fragmentary, and some data are false. The purpose of the publication is to reconstruct the life and work path of the honored industry figure, evaluate his contribution to the cause of Victory, and show the features of the USSR industry management in the 1940s using the work of M.A. Dlugach as an example.. The publication is based on materials from the Central State Archive of Historical and Political Documents of St. Petersburg: personal files of leaders, memos on the organization of production and evacuation from Leningrad, and transcripts of speeches. For five years M.A. Dlugach worked his way up from a foundry technician to the sectoral secretary of the Leningrad City Communist Party Committee. With the outbreak of the war, a significant share of responsibility for organizing the production of new types of weapons fell on his shoulders. After the evacuation of the tank and artillery production of the Kirov Plant, carried out under his leadership, M.A. Dlugach headed the remaining dispersed in the city workshops of the enterprise, being the Kirov Plant Director from the end of 1941 to the beginning of 1943. In 1943, he headed the Chelyabinsk Kirov Plant for about six months, and was later transferred to Chirchik. As the Director of the Chirchik plant Sredazkhimmash, he took part in the implementation of the Nuclear Project. Upon returning to Leningrad in 1948, he no longer held high positions, returning to the profession of a metallurgical engineer. At the peak of his career, M.A. Dlugach invariably found himself in the most important areas of work - he was responsible for the Leningrad mechanical engineering, for the production of tanks in the Urals and of heavy water for nuclear reactors. Contribution of M.A. Dlugach to maintaining the defense capability of the USSR should not be forgotten.
Non-pharmacological interventions for side effects of antineoplastic chemotherapy prioritized by patients: systematic review
Authors:   Pontificia Universidad Javeriana, Facultad de Enfermería. Bogotá, Colombia., Gómez-Neva María Elizabeth , Pulido Ramirez Edwin , Ibañez Rodriguez Leidy Johana , Caroprese Oscar , Buitrago-Lopez Adriana
Published: October 2024

Introduction: Different non-pharmacological interventions have been studied to manage symptoms derived from chemotherapy, but their effectiveness is unknown. Objective: To describe non-pharmacological interventions for managing symptoms secondary to antineoplastic chemotherapy in adults. Materials and Methods: Systematic review of analytical experimental and observational studies (2021 to 2023). The studies were selected, and data was extracted in parallel. Discrepancies were resolved with a third reviewer. The risk of bias was assessed using the Risk of Bias (RoB) tool and The Newcastle-Ottawa Scale (NOS). The literature was synthesized descriptively based on prioritized outcomes. Results: The prioritized outcomes were neutropenia, pain, neuropathy, nausea, vomiting, alopecia, anorexia, and sleep disorders. Out of 7520 references found, 62 were included for analysis. Acupressure showed a possible effect in controlling symptoms such as nausea and vomiting. The intervention with cold on the scalp showed differences in the stages of alopecia severity. Other interventions showed heterogeneity. Discussion: Non-pharmacological interventions have been widely described in observational and experimental studies in the control of side effects of chemotherapy; however, there is homogeneity and a high risk of bias. Conclusion: Acupressure, muscle massage, music therapy, foot baths, and other interventions have been studied for nausea, vomiting, sleep disorders, neutropenia, alopecia, anorexia, pain, and neuropathy as secondary symptoms prioritized by patients. It is necessary to standardize both the interventions and how measure the outcomes.
Knowledge on muscle strength among health professionals in Colombia: cross- sectional study
Authors:   Universidad de Santander, Facultad de ciencias médicas y de la salud,  Instituto de investigación Masira, Bucaramanga, Colombia, Ruiz-Uribe Gabriela , Lopez-Lopez Jose P. , Gómez-Montoya Isabela , Sanchez-Martínez Yuri , Reyes Mabel , Gonzalez Ana M. , Castañeda-Hernandez Álvaro , Cohen Daniel D. , Gomez-Arbelaez Diego , Otero Johana , Martínez-Bello Daniel , Lopez-Jaramillo Patricio ,   Universidad de Santander, Facultad de ciencias médicas y de la salud,  Instituto de investigación Masira, Bucaramanga, Colombia. Universidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Quito, Ecuador.
Published: October 2024

Introduction: Low muscle strength is a risk factor for various health conditions such as cardiometabolic diseases, neurodegenerative syndromes and mortality. Objective: Evaluate the knowledge of muscle strength in health professionals in Colombia. Materials and Methods: An analytical cross-sectional study was conducted in health professionals attending two continuing medical education events. Three components were evaluated through a questionnaire: identification of muscle strength as a risk factor for health conditions, measurement of muscle strength and education in muscle strength. Results: 501 participants (52.49% women) were evaluated. Of these, 53.89% (n=270) were general practitioners, 18.16% (n=91) specialists and 6.18% (n=31) nurses. The association between low muscle strength and cardiometabolic diseases was identified by 56.67% (n=153) of general practitioners and 41.94% (n=13) of nurses. The indication for measuring muscle strength in older adults was recognized by 86.81% (n=79) of specialist physicians and 41.94% (n=13) of nurses. 32.93% (n=165) of the participants were aware of some method for measurement. Physiotherapists were the group that mostly reported measuring muscle strength by 83.33% (n=20). Only 29.03% (n=9) of the nurses had received academic information on muscle strength. Discussion and Conclusions: This study demonstrates the lack of knowledge on low muscle strength, its association with health conditions and measurement methods, and the lack of information about published literature on the subject. Educational interventions are needed to incorporate muscular strength evaluation into the clinical practice.
Trends of Global Legal AI Market and Factors of Its Russian Segment’s Development
Authors: Inshakova Elena
Published: October 2024

From the perspective of applying a systems-evolutionary approach and studying the results of a number of modern research studies into the processes of formation and development of the Legal AI market (artificial intelligence system for the legal field) and LegalTech market (digital platforms, software products, and tools used to optimize the provision of legal services), the article reveals the growing potential of these market segments. The author takes into account the prospects for using their market objects for the technological (digital) modernization of the Russian companies that provide qualified legal support for the economic activities of business entities, and enhancing on this basis their competitiveness under evolving Industry 4.0, the economy’s digital transformation, and the unfavorable impact of the external environment. Given the limited open access to up-to-date statistics on the state of all studied market segments, this paper mainly focuses on the modern dynamics of the Legal AI market (more precisely, the Legal AI Software Market, the market for the AI software in the legal field), its subject and object, and geographical structure, along with the development trends and forecasts due to the profitability of the market participants’ activities, growing investment, and other factors that result in expanding this market value in the regions of the world and in Russia.
Modern Factors of Influence on the Formation of Strategic Partnership in the Russian Federation
Authors: Donets Lyubov , Shtikhova Alexandra
Published: October 2024

Scientific approaches to defining the essence of the concepts “globalization,” “intellectualization,” and “digitalization” have been identified and characterized. A descriptive approach to the formation of strategic partnerships in globalization, intellectualization, and digitalization has been developed; the proposed approach represents a set of structural and logical connections between modern factors of influence, socio-economic transformations, and determinants that ensure the further development of strategic partnerships. It is substantiated that the development trends of world economies and the transition to a multipolar world influence the forms, content, and nature of the strategic partnership, entailing structural transformation in all spheres of the economy of the Russian Federation. We have identified the key elements of transformational changes in the strategic partnership format, including information and intellectual components. As a result of a systematic analysis of theoretical and methodological approaches to the study of informatization and intellectualization processes, the priority role of knowledge was determined. The substantiation of the relationship between the knowledge system and direct entrepreneurial activity made it possible to establish the basic importance of knowledge management in intellectualization as a factor of influence on the formation of strategic partnerships. Based on a study of theoretical and scientific-practical approaches to the digital transformation of business and the country’s economy as a whole, the forms of strategic partnership in the Russian Federation are characterized, and their advantages and limitations are determined.
Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention
Authors: Becerra Juan C , Hitchcock Lauren , Vu Khoa , Gach Johannes S
Published: October 2024

Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine development. Continual advancements in identifying more potent bnAbs, along with their capacity to trigger antibody-mediated effector functions, coupled with modifications to extend their half-life, position them as promising candidates for both HIV-1 treatment and prevention. While current pharmacological interventions have made significant progress in managing HIV-1 infection and enhancing quality of life, no definitive cure or vaccines have been developed thus far. Standard treatments involve daily oral anti-retroviral therapy, which, despite its efficacy, can lead to notable long-term side effects. Recent clinical trial data have demonstrated encouraging therapeutic and preventive potential for bnAb therapies in both HIV-1-infected individuals and those without the infection. This review provides an overview of the advancements in HIV-1-specific bnAbs and discusses the insights gathered from recent clinical trials regarding their application in treating and preventing HIV-1 infection.
Pathogenic Escherichia coli change the adhesion between neutrophils and endotheliocytes in the experimental bacteremia model
Authors: Pleskova Svetlana N , Bezrukov Nikolay A , Bobyk Sergey Z , Gorshkova Ekaterina N , Novikov Dmitri V
Published: October 2024

Septicemia caused by gram-negative bacteria is characterized by high death rate due to the endotoxin release. Since the septicemia depends not only on biochemical aspects of interactions in the system bloodstream, the study of mechanical interactions is also important. Using a model of experimental septicemia caused by E. coli, a hyperproduction of integrins CD11a and CD11b by neutrophils was shown, but this did not lead to the establishment of strong adhesion contacts between endothelial cells and neutrophils. On the contrary, adhesion force and work, as assessed by FS spectroscopy, were statistically significantly reduced in the presence of bacteria. It has also been shown that exposure to the pathogenic strain E. coli 321 increases the stiffness of the membrane-cytoskeleton complex of endothelial cells and bacteria significantly change their morphology on long-term observation. At the same time, we observed the death of neutrophils by apoptosis. Thus, it was shown that besides lipopolysaccharide release there are other pathogenic factors of E. coli: decrease in the interaction between neutrophil and endothelial cell caused by an increase of the endothelial cell rigidity and apoptotic death of neutrophils probably as a result of adhesins and exotoxin effects. Obtained results should be taken in mind during the therapy of septicemia.
Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts
Authors: Acs-Szabo Lajos , Papp Laszlo Attila , Miklos Ida
Published: October 2024

The role of model organisms such as yeasts in life science research is crucial. Although the baker’s yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the contribution of the fission yeasts (Schizosaccharomyces) to life science is also indisputable. Since both types of yeasts share several thousands of common orthologous genes with humans, they provide a simple research platform to investigate many fundamental molecular mechanisms and functions, thereby contributing to the understanding of the background of human diseases. In this review, we would like to highlight the many advantages of fission yeasts over budding yeasts. The usefulness of fission yeasts in virus research is shown as an example, presenting the most important research results related to the Human Immunodeficiency Virus Type 1 (HIV-1) Vpr protein. Besides, the potential role of fission yeasts in the study of prion biology is also discussed. Furthermore, we are keen to promote the uprising model yeast Schizosaccharomyces japonicus, which is a dimorphic species in the fission yeast genus. We propose the hyphal growth of S. japonicus as an unusual opportunity as a model to study the invadopodia of human cancer cells since the two seemingly different cell types can be compared along fundamental features. Here we also collect the latest laboratory protocols and bioinformatics tools for the fission yeasts to highlight the many possibilities available to the research community. In addition, we present several limiting factors that everyone should be aware of when working with yeast models.
Report of RILEM TC 281-CCC: insights into factors affecting the carbonation rate of concrete with SCMs revealed from data mining and machine learning approaches
Authors: Vollpracht A. , Gluth G. J. G. , Rogiers B. , Uwanuakwa I. D. , Phung Q. T. , Villagran Zaccardi Y. , Thiel C. , Vanoutrive H. , Etcheverry J. M. , Gruyaert E. , Kamali-Bernard S. , Kanellopoulos A. , Zhao Z. , Martins I. M. , Rathnarajan S. , De Belie N.
Published: October 2024

The RILEM TC 281–CCC ‘‘Carbonation of concrete with supplementary cementitious materials’’ conducted a study on the effects of supplementary cementitious materials (SCMs) on the carbonation rate of blended cement concretes and mortars. In this context, a comprehensive database has been established, consisting of 1044 concrete and mortar mixes with their associated carbonation depth data over time. The dataset comprises mix designs with a large variety of binders with up to 94% SCMs, collected from the literature as well as unpublished testing reports. The data includes chemical composition and physical properties of the raw materials, mix-designs, compressive strengths, curing and carbonation testing conditions. Natural carbonation was recorded for several years in many cases with both indoor and outdoor results. The database has been analysed to investigate the effects of binder composition and mix design, curing and preconditioning, and relative humidity on the carbonation rate. Furthermore, the accuracy of accelerated carbonation testing as well as possible correlations between compressive strength and carbonation resistance were evaluated. One approach to summerise the physical and chemical resistance in one parameter is the ratio of water content to content of carbonatable CaO (w/CaOreactive ratio). The analysis revealed that the w/CaOreactive ratio is a decisive factor for carbonation resistance, while curing and exposure conditions also influence carbonation. Under natural exposure conditions, the carbonation data exhibit significant variations. Nevertheless, probabilistic inference suggests that both accelerated and natural carbonation processes follow a square-root-of-time behavior, though accelerated and natural carbonation cannot be converted into each other without corrections. Additionally, a machine learning technique was employed to assess the influence of parameters governing the carbonation progress in concretes.
Mechanical, physical and durability performance of engineered cementitious composites prepared with calcium aluminate cement
Authors: Zokaei Shahin , Siad Hocine , Lachemi Mohamed , Mahmoodi Obaid , Ozcelikci Emircan , Şahmaran Mustafa
Published: October 2024

The aim of this research is to fill a gap in existing studies by exploring the use of calcium aluminate cement (CAC) as an eco-friendly substitute for ordinary Portland cement (OPC) in engineered cementitious composites (ECCs). The study investigates the impact of CAC, both with and without the presence of fly ash (FA), on the mechanical, physical, durability and microstructural properties of ECC–CAC mixtures. Various proportions of FA to CAC up to 1.5 were considered, while assessing different engineering parameters of compressive and flexural strengths, ductility, ultrasonic measurements, chloride penetrability and drying shrinkage. Moreover, scanning electron microscopy coupled with energy dispersive X-ray analysis and X-ray diffraction were used to analyse the reaction products related to CAC and/or FA in selected mixtures. Higher strengths of CAC–ECC were achieved at earlier curing ages, although the transformation of CAC’s metastable phases led to reduced strengths in ECC–CAC mixtures compared to the control ECC during extended curing periods. Furthermore, the combination of FA with CAC played a crucial role in avoiding the hydrates conversion and minimising the shrinkage in CAC–ECC, achieving even lower shrinkage levels than those observed in control OPC–ECC.
Work demand and voluntary turnover intention of independent auditors
Authors: Weissmantel Cristiane Wornath , Silva Jessica Merco do Nascimento e , Cunha Paulo Roberto da
Published: October 2024

This study aimed to analyze the influence of work demand on the voluntary turnover intention of independent auditors, considering the mediating effects of work engagement and Burnout Syndrome. The research is descriptive, of the survey type, with a quantitative approach, and includes a sample of 196 Brazilian independent auditors. The results confirmed the positive association between work demand and the voluntary turnover intention of auditors. Additionally, it was evidenced that work engagement acts as a mediator in this relationship. On the other hand, Burnout Syndrome does not play a mediating role in the relationship between work demand and turnover intention. Finally, it was observed that work engagement exerts a negative and neutralizing influence on Burnout Syndrome. These findings provide auditing firms with a deeper understanding of the antecedents of independent auditors' turnover intention.
Luz, câmera, ação! Profissão contábil e o contador
Authors: Almeida Laisla Alves de , Ferreira Denize Demarche Minatti , Dalcero Kátia
Published: October 2024

O artigo analisa como contadores são retratados em longas-metragens e séries nas plataformas de streaming, incluindo O Procurado, Brooklyn, Amor de Verão e Ozark. O método é qualitativo e se baseia em Langer (2004) que propõe cinco etapas: (i) identificação do objeto e tema de pesquisa; (ii) seleção do filme; (iii) crítica externa do filme; (iv) crítica interna do filme; e (v) comparação e análise de conteúdo. Os resultados apontam que prevalece o estereótipo do contador, tanto negativo – como um profissional fraco, submisso e sem criatividade – quanto positivo, sendo retratado como honesto, criativo e sonhador. Além disso, os contadores são frequentemente associados a escândalos corporativos, fraudes e lavagem de dinheiro.
Construcción del concepto de calidad educativa: un estudio de teoría fundamentada en profesores del sector oficial
Authors: Duque Hansel , Méndez Jennifer
Published: October 2024

La presente investigación tuvo como objetivo construir y comprender el concepto de calidad educativa desde la perspectiva de docentes del sector oficial. Se realizó un estudio cualitativo basado en la teoría fundamentada. Los participantes fueron 11 profesores que respondieron entrevistas semiestructuradas, analizadas a través de los lineamientos de la teoría fundamentada. Los principales resultados encontrados evidencian que el modelo propuesto distingue una categoría central denominada “integralidad de la calidad educativa” y a partir de esta, se desprenden 5 dimensiones bajo las cuales construyen el concepto, las cuales apuntan a la formación integral del estudiante; estas son: los actores de la educación, contenidos curriculares y su relevancia en la educación, visión empresarial de la educación, medición de la calidad por las Pruebas Saber y equidad y calidad educativa. Esto muestra el significado multidimensional que le dan los docentes al concepto de calidad educativa, para ellos, cada una de las dimensiones que hacen parte de esta, cumplen una función, y separarlas implicaría el desconocimiento que se tiene sobre las diferentes contribuciones que cada una de ellas aporta a la calidad educativa. Los resultados de este estudio son de gran utilidad para avanzar en una mejor comprensión de cómo se debe percibir la calidad educativa y pensar en nuevas formas de evaluarla, que den cuenta de los procesos que se llevan en cada institución, sin anular las particularidades del contexto.
Cambios asociados a un proceso de intervención de un programa de estrategias de aprendizaje sobre la metacomprensión y el desempeño metacognitivo
Authors: Hurtado Vinasco Karen Sofía , Henao Mejía Juan Pablo , Montoya Londoño Diana Marcela , Gutierrez de Blume Antonio Partida
Published: October 2024

La metacognición se aborda desde la perspectiva de Schraw & Moshman (1995), quienes la definen como la capacidad de un individuo para comprender, reflexionar y controlar su propio aprendizaje. Esto implica tener conocimiento sobre cómo funciona la cognición y cómo regularla. Esta investigación se realizó en un contexto de aula de filosofía, en el que es importante tener en cuenta que en esta área se ha investigado poco desde la perspectiva metacognitiva. Sin embargo, los estudios realizados hasta el momento, han demostrado un buen desempeño entre la filosofía y la metacognición, tal como lo mencionan Worley & Worley (2019), quienes sugieren que la filosofía puede mejorar la metacognición y la existencia de una conexión útil entre ambas áreas.El objetivo de este estudio fue determinar el efecto de un programa de estrategias de aprendizaje en el desempeño metacognitivo y la metacomprensión en una muestra de estudiantes de educación media en clase de filosofía de una institución privada en la ciudad de Manizales. Estas estrategias de aprendizaje se basan en el trabajo de Hattie (2009) y se adaptaron para ser utilizadas en esta intervención. Para evaluar los resultados, se aplicó el inventario de habilidades metacognitivas MAI estandarizado para Colombia por Huertas Bustos et al. (2014) y el inventario de habilidades metacognitivas en estrategias de lectura MARSI de Mokhtari & Reichard (2002), antes y después de realizar la intervención. Los resultados de esta investigación indicaron de forma mutua que el MAI y el MARSI, mostraron mejoras significativas en el postest, lo que sugiere un efecto positivo del programa de estrategias de aprendizaje utilizadas. Además, se observó un mayor impacto y potencia en cuatro de los componentes evaluados. Esto demuestra la importancia de implementar estrategias de aprendizaje metacognitivas en el aula de filosofía para mejorar la comprensión y el desempeño académico de los estudiantes.
Ensino do Building Information Modeling (BIM) em Instituições de Ensino Superior no Brasil
Authors: Bonfante Hortência Santos Teixeira , Palmisano Angelo , Godoy Jeane Aparecida Rombi de
Published: October 2024

Building Information Modeling (BIM) has emerged as a necessary tool in the architecture, engineering, construction and operations scenario, offering an innovative and integrated approach not only for project development, but also contributing to the construction management and maintenance of buildings. . In the Brazilian context, academia has dedicated special attention to BIM, reflected in the production of theses and dissertations carried out over the last few years. This research aimed to identify the main trends and pedagogical approaches used in the productions found, presenting their strengths and advances verified in the use of this methodology, as well as the weaknesses or limiting points, based on Brazilian academic production on teaching BIM in the period from 2013 to 2020, resulting from the analysis of theses and dissertations published in the CAPES Catalog of Theses and Dissertations, which address the topic of Construction Information Modeling or Building Information Modeling in the dimension of its teaching. classifies as applied, exploratory, with a qualitative approach, using the bibliographic research method and application of the content analysis technique. It is hoped that, through the results obtained, the adoption of the BIM methodology in undergraduate courses in architecture and urbanism and related areas can be encouraged in the country.
HISTORY OF JAPAN'S USE OF SOFT POWER TO ACHIEVE NATIONAL INTERESTS: LESSONS FOR UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Manzhola Volodymyr , Maloivan Olena ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: October 2024

This article focuses on the phenomenon of soft power in the context of Japan. It examines the historical development of the country's soft power, the institutions and initiatives that ensure it, and the challenges that have been shaped in different historical periods. Given that today Japan is a country with one of the most effectively developed mechanisms of cultural diplomacy, it can serve as an example for states seeking to develop their own soft power institutions and fields. In particular, the author describes the relationship between Japanese soft power and the economy in its various sectors, and explains the phenomenon of the popularity of Japanese cultural products abroad. Various international rankings are used to analyse these phenomena. The research methods used include description, synthesis, generalisation, and comparison. The author also analyses the history and historical and foreign policy factors that influenced the development of Japan's soft power. Accordingly, the author describes how Japan has managed to overcome historical and geographical challenges in building soft power and how it protects its national interests. From this analysis, the author also derives recommendations for Ukraine in building its own soft power, having described and characterised its current state. Accordingly, it was found that the success factor for Japanese soft power was economic development, which allowed for the rapid expansion of various industries from gastronomy and sports to music and literature. But the most attractive thing about the Japanese cultural product is its modernity and compliance with trends, as well as the wide choice that attracts many people. In addition, Japan has made efforts to become a leader in unique policy areas such as the environment or know-how.