bluuebunny/crossref_metadata_2025 huggingface dataset:
TEN-YEAR OUTCOMES OF TIPS FOR BUDD-CHIARI SYNDROME: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: MORENO Mariana Oliveira Amarante , PAZ Cláudio Luiz da Silva Lima , DEZAN Maria Gabriela Fernandes , CAVALCANTE Lourianne Nascimento , LYRA Andre Castro
Published: June 2024

ABSTRACT Background: Budd-Chiari syndrome (BCS) results from the obstruction of the hepatic venous flow, usually at the level of the hepatic vein or inferior vena cava. When left untreated, it can progress with several complications, including liver cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) appears to be effective in a subgroup of BCS patients. Objective: To perform a systematic review and meta-analysis of TIPS effectiveness in BCS treatment, considering the survival rate, reduction in portosystemic pressure, need for liver transplantation, technical failure, and shunt dysfunction for up to 10 years of follow-up. Methods: We evaluated 17 studies published in PubMed, Science Direct, Web of Science, and SCOPUS databases, which used TIPS as a treatment for BCS, comprising 618 subjects between 18 and 78 years old. We assessed the bias risk by the NOS, NHI, and JBI scales for cohort studies, before-after studies, and case series, respectively. We conducted the meta-analyses by extracting the number of events and the total patients evaluated to perform the proportion meta-analyses using the R software (“meta” package - version 4.9-6). Results: The pooled results (95%CI) showed a 19% (25.9-12.5%) rate of portosystemic pressure reduction, 6% (1-12%) rate for the need for liver transplants despite the use of TIPS, 2% (1-6%) technical failure rate, 30% (18-46%) shunt dysfunction rate, and 88% (81-93%) for the mean frequency of patients alive between 1 and 10 years after the procedure. We stratified survival rate and found an 86% (74-93%) prevalence of living subjects during less than five years, 92% (83-97%) at five years, and a 77% frequency (68-83%) of patients alive ten years after the TIPS placement. Conclusion: TIPS is an effective treatment for BCS, providing a high 10-year frequency of living patients and a significant decrease in portosystemic pressure. The need for liver transplants after TIPS and the technical failure rate is low.
INFLUENCE OF ESOPHAGEAL MOTILITY IMPAIRMENT ON UPPER AND LOWER ESOPHAGEAL SPHINCTER PRESSURE IN CHAGAS DISEASE
Authors: DANTAS Roberto Oliveira
Published: June 2024

ABSTRACT Background: Chagas disease causes digestive anatomic and functional changes, including the loss of the myenteric plexus and abnormal esophageal radiologic and manometric findings. Objective: To evaluate the association of abnormal esophageal radiologic findings, cardiac changes, distal esophageal contractions, and complaints of dysphagia and constipation in upper (UES) and lower (LES) esophageal sphincter basal pressure in Chagas disease patients. Methods: The study evaluated 99 patients with Chagas disease and 40 asymptomatic normal volunteers. The patients had normal esophageal radiologic examination (n=61) or esophageal retention without an increase in esophageal diameter (n=38). UES and LES pressure was measured with the rapid pull-through method in a 4-channel water-perfused round catheter. Before manometry, the patients were asked about dysphagia and constipation and submitted to electrocardiography and chest radiography. Results: The amplitude of esophageal distal contraction decreased from controls to chagasic patients with esophageal retention. The proportion of failed and simultaneous contractions increased in patients with abnormal radiologic examination (P<0.01). There were no significant differences in UES and LES pressure between the groups. UES pressure was similar between Chagas disease patients with cardiomegaly (n=27, 126.5±62.7 mmHg) and those without it (n=72, 144.2±51.6 mmHg, P=0.26). Patients with constipation had lower LES pressure (n=23, 34.7±20.3 mmHg) than those without it (n=76, 42.9±20.5 mmHg, P<0.03). Conclusion: Chagas disease patients with absent or mild esophageal radiologic involvement had no significant changes in UES and LES basal pressure. Constipation complaints are associated with decreased LES basal pressure.
Intervencionismo obstétrico y maternalización de las mujeres en la atención del parto en Uruguay, 1920-1940*
Authors: Alemán Natalia Magnone
Published: June 2024

Resumen En este artículo se analizan discursos de médicos de referencia en la creación de la especialidad en la atención del parto: la ginecotocología. Entre 1920 y 1940, bajo la influencia del pensamiento eugenésico y maternalista, en un contexto de valorización del bienestar de la infancia, la medicina construyó un nuevo intervencionismo obstétrico bajo el fundamento de mejorar la viabilidad fetal. En ese marco se apeló al supuesto “instinto maternal” femenino para mejorar la aceptación del mandato médico. A la vez, los médicos reconocieron sus dificultades para asistir de forma adecuada. No esperaban el tiempo suficiente y tendían a intervenir más de lo necesario en procesos fisiológicos que no lo requerían.
“Nada sobre nós, sem nós”: a surdez no ensino de história e na produção historiográfica, 2015-2022*
Authors: Fernandes Valter Lenine
Published: June 2024

Resumo O texto aponta resultados parciais de uma pesquisa em andamento sobre a surdez no ensino de história e na produção historiográfica entre 2015 e 2022. O trabalho problematiza o lugar da pessoa com deficiência nos periódicos A1 e A2 e nos projetos pedagógicos de cursos de graduação em história (formação de professores e pesquisadores) da Universidade de São Paulo e da Universidade Estadual de Campinas, por conta de serem indicadas como as mais bem posicionadas no ranking de uma pesquisa realizada pela Folha de S.Paulo, levando-se em conta os critérios de articulação entre a Lei Brasileira de Inclusão, lei 13.146, de 6 de julho de 2015, e a formação inicial desses profissionais.
Programa de Assistência Integral à Saúde da Mulher, 40 anos de uma história: entrevista com Ana Maria Costa
Authors: Costa Ana Maria , Bonan Claudia , Rodrigues Andreza Pereira
Published: June 2024

Resumo A entrevista marca os 40 anos do Programa de Assistência Integral à Saúde da Mulher e tem como objetivo revisitar a história dessa política de saúde inovadora, do contexto em que foi criada e da geração que a levou adiante, a partir da narrativa de uma pessoa-chave, Ana Maria Costa, que protagonizou o processo de sua criação, desde a concepção até a elaboração de seu texto final. Lançada em 1983, a política foi pioneira em propor e incorporar os princípios de universalidade, equidade e integralidade, que seriam os fundamentos do Sistema Único de Saúde, e introduzir a perspectiva dos direitos reprodutivos das mulheres.
Mixed linear model for the prediction of infiltration rates in urban pervious concrete pavements in dense wooded parks
Authors: Balbo José Tadeu , Albarracin Orlando Yesid Esparza , Ho Linda Lee , Batezini Rafael , de Oliveira Curvo Filipe
Published: June 2024

Abstract Clogging of porous concrete pavements is understood as a performance pathology within this peculiar concrete component. Albeit the clogging performance of porous concrete pavements is a sensitive topic in technical literature, most studies refer to laboratory investigations on concrete samples using different kinds of apparatus for the simulation of loss of permeability due to debris insertion on porous interstices. However, infiltration rate measurements are the basis for defining maintenance needs in actual pavements and shall be carried out periodically to measure and endorse infiltration rate adequacy as the kern of a clogging management protocol. This study dealt with a field experiment in a pervious concrete sidewalk surrounded by a wooded garden with tropical native and a variety of exotic trees. Over four years, eleven monitoring measurements were carried out using the ASTM C1701 infiltration ring test. The main contribution of this paper is a proposition of a mixed linear prediction model considering conditioned exponential distribution and a random normal intercept for the infiltration rate. From residual analysis and diagnosis plots, it can be seen that the proposed model presents a goodness of fit, allowing anticipation of infiltration rates reduction due to clogging by dense organic matter. Minimum infiltration rate is taken as 0.1 cm/s and such condition was achieved in a couple of months, awakening consciously to consider three to four intensive cleaning maintenance per year in dense wooded areas like public parks.
Effects of alloying ZrB2(HfB2)–SiC with tantalum on the structure and resistance to high-temperature oxidation and ablation: A review
Authors: Didenko A. A. , Astapov A. N. , Terentieva V. S.
Published: June 2024

This review presents a comprehensive analysis of the impact of tantalum alloying on the structure, heat resistance, and ablation resistance of ZrB2(HfB2)–SiC ultra-high-temperature composites. The influence of the primary phase content on the effects on the structural and morphological features of the oxide layers and their protective efficiency is analyzed. It is shown that alloying positively affects the composite's behavior by enhancing the viscosity and thermal stability of the glass phase, decreasing anionic conductivity, partially stabilizing the ZrO2(HfO2) lattice, and forming temperature-resistant complex oxides, such as Zr11Ta4O32 or Hf6Ta2O17 on the surface. It has been established that the alloying can have negative effects, including an increase in the liquid phase content, oxide film discontinuity, ZrO2(HfO2) grain damage due to TaB2 oxidation, or a significant amount of gas release due to TaC oxidation, as well as the formation of oxygen diffusion channels during the verticalization of Zr11Ta4O32 or Hf6Ta2O17 platelets. It is essential to note that the oxidation and ablation resistance, as well as the mechanisms driving composite behavior, differ depending on the alloying compounds and test conditions. Overall, this study sheds light on the role of tantalum alloying in enhancing the performance of ZrB2(HfB2)–SiC UHTC and highlights the importance of understanding the underlying mechanisms that govern their behavior.
The impact of impurities on the Al–Fe–C system phase composition changes during sintering
Authors: Korosteleva E. N. , Knyazeva A. G. , Anisimova M. A. , Nikolaev I. O.
Published: June 2024

Manufacturing waste can be not only recycled but also utilized as a source of chemical elements and as a component of powder materials. Steel swarf are a complex multicomponent material with a high iron content, while impurities such as carbon can affect the diffusion interaction in the chip and metal powder mixture. In this study, we investigate the diffusion interaction between aluminum and steel swarf using temperature-controlled vacuum sintering. We analyzed the resulting mixture’s microstructure and phase composition, and observed that sintering creates a multiphase structure in which FeAl iron aluminide occupies at least 30 vol. %. Despite the high sintering temperature, we also observed residual aluminum and iron. Incomplete transformation may result form refractory products that inhibit diffusion or impurities that influence the magnitude and direction of the diffusion fluxes. To confirm the impurities’ role in the diffusion interaction kinetics, we developed simulation models of the intermetallic phase growth for a flat and spherical particle embedded in aluminum. The model consider cross-diffusion fluxes in the emerging phase regions and possible effects of impurities on the concentration limit for the new phase’s existence. We derived approximate analytical solutions to analyze the emerging phase growth trends under various model parameters.
Thermal explosions in (Ti, Zr, Hf, Nb, Ta) carbon mixtures
Authors: Vadchenko S. G. , Sedegov A. S. , Kovalev I. D.
Published: June 2024

This research focuses on investigating the ignition and thermal explosion behavior of (Ti, Zr, Hf, Nb, Ta) + 5C mixtures that have been mechanically activated. First, we mechanically activated the metal powder mixtures to produce composite particles consisting of Ti, Zr, Hf, Nb, and Ta, followed by the addition of carbon, and re-activation. An activation time of 120 min at 347 rpm resulted in the formation of solid solutions from the metals in the mixture, while large tantalum particles were preserved. The resulting mixtures were then pressed into pellets, which were heated in argon until ignition occurred. The ignition process involves multiple phases, with the first being inert heating, followed by progressive heating at t = 420÷450 °C, and a  subsequent endothermic phase transformation at 750–770 °C. The temperature then rises rapidly, resulting in a thermal explosion that forms complex carbides, leaving some unreacted tantalum behind. The (Ti, Zr, Hf, Nb, Ta)C5 activated mixtures and high entropy solid solution are unstable and  release titanium and zirconium carbides when heated above 1300 °C, causing changes to the composition of the (Ti, Zr, Hf, Nb, Ta)C5 final product. When diluted by adding 25 and 50 % of the final product, the effective activation energy Ea for the (Ti, Zr, Hf, Nb, Ta) + 5C reaction in the 1100–1580 °C temperature range was found to be 34 kJ/mol.
EFFICIENCY OF THE PRODUCT-DEVELOPMENT PROCESS AS A FACTOR DETERMINING THE EFFECTIVENESS OF IMPLEMENTATION FOR SUBSEQUENT PROJECT PHASES ACC APQP
Authors: Rudolf Łukasz , Roszak Marek
Published: June 2024

This study presents a tool integrating PDCA Deming cycle and Design for Six Sigma principles to aid component development (especially dedicated for innovative projects). Designed for universal use across APQP (Advanced Product Quality Planning) phases, the tool guides through five key stages: Identify, Define, Design, Optimize, and Validate. Each stage involves specific actions and approvals, ensuring thorough development and risk assessment. Notably, the tool accommodates changing product requirements and validation challenges, allowing for adjustments without project delays. Its adaptability within the APQP framework is crucial for complex product development. The implementation at Tenneco demonstrates its effectiveness in structuring and overseeing development processes and improving project outcomes. Future analyses will delve into its impact and guide further research.
N-DOPED POROUS CARBON DERIVED FROM A DEEP EUTECTIC SOLVENT AND ITS APPLICATION IN SOLID-PHASE EXTRACTION OF PROFENOFOS FROM FRUITS
Authors: Huo Weitao , Gao Shuang , Chen Xiaolu , Yu Yue , Yuan Hongjing
Published: June 2024

Porous N-doped carbon materials with glucose and urea derived from a deep eutectic solvent, and their performance in determining pesticides were investigated. The carbon materials were characterized with nitrogen absorption, transmission electron microscopy, X-ray photoelectron spectroscopy, and the results showed that they had high specific surface areas, pore volumes and rich functional groups. Under optimized conditions, this method showed a good linearity (0.2–2.0 µg/mL) and high sensitivity (detection limit of 0.023 µg/mL, S/N = 3). The proposed method was successfully applied in an analysis of a fruit sample with recoveries ranging from 97.2 % to 103.3 %, and good reproducibility was achieved. This work revealed great potentials of a porous N-doped carbon material used as an excellent sorbent material in analyzing organophosphorus pesticides.
RESEARCH STATUS AND PROSPECTS FOR TIG-MIG HYBRID-ARC-WELDING TECHNOLOGY
Authors: Li Yinghao , Zong Rang , Zhang Yujiao , Yao Jingzhuo
Published: June 2024

TIG-MIG hybrid welding integrates the merits of tungsten insert-gas welding (TIG) and metal inert-gas welding (MIG), and achieves a new material-joining process with high quality, high efficiency and low cost. However, TIG-MIG hybrid welding also had some shortcomings, such as a complex process, unstable arc, large heat input, limiting its application. To further improve and promote TIG-MIG hybrid welding, numerous universities and research institutes have put forward a series of improvement programs that achieve relatively good results. In this study TIG-MIG hybrid welding is discussed in three aspects: the welding-process improvement, welding-parameters optimization and numerical simulation of the welding process. It was found that the stability of the hybrid arc welding process and the quality of the weld bead can be improved by improving the current polarity, wire type and arc swing. The TIG current, the distance between the wire and tungsten, and the heat input had an important impact on the weld quality and the formation of defects. A numerical simulation of the welding process analyzed the effects of torch angle, the distance between the wire and tungsten, the welding speed and the temperature fields on the arc morphology, molten-pool behavior, and droplet transfer. According to the above analysis, it summarized the current research status of TIG-MIG hybrid welding, and then proposed future research directions based on the existing shortcomings and deficiencies.
EXPERIMENTAL INVESTIGATION OF GREEN CONCRETE USING BOVINE FAECES ASH AND NON-DEGRADABLE PLASTIC WASTE MATERIALS
Authors: J. Fehlberg , M. S. Ravi Kumar
Published: June 2024

Concrete is widely used in all kind of construction purpose and it is composed of cement, fine and coarse aggregates. To make the eco-friendly and economical construction, this research partially replace cement with cow dung ash to prepare the concrete. Non-biodegradable plastic trash is thus added to the concrete as an admixture in order to increase the tensile and compressive strength. Super plasticizers are also added to the concrete to increase its strength. In this study, the cement was partly substituted with cow dung ash in the proportions of 5%, 10%, 15%, 20% while non-degradable plastic waste materials was used as an admixture in the proportions of 1%, 1.5%, and 2% to create green concrete. To evaluate the performance and strength of the manufactured concrete samples (cube and cylinder), they are subjected to split tensile, flexural, and compressive strength tests after curing for 7, 14, and 28 days, respectively. For all the M20 grade of concrete mixes, addition of 15% of cow dung ash as a replacement of cement and 1.5% of non-degradable plastic waste material gives the maximum compression and tensile strength when comparing the control mix concrete. Hence this proves that partial replacement of cement with cow dung ash and addition of non-degradable plastic waste material as a admixture gives better results than normal M20 grade concrete which has better strength and eco-friendly in nature.
SOP for personalized directions in e-prescription v1
Authors: Reis Zilma , Silvina Pagano Adriana , lage eura , dos Santos Dias Cristiane , José Ramos de Oliveira Isaias , Miranda Varella Pereira Glaucia
Published: June 2024

Purpose: This SOP outlines a set of patient-centered guidelines designed to enhance the personalization, clarity, and acceptability of e-prescription instructions. These guidelines are intended for healthcare professionals, aiming to improve the quality and effectiveness of prescription communications. Context: This procedure utilizes prescriptions already made by skilled professionals (doctors, nurses, dentists, pharmacists) within the e-SUS Primary Health Care System (Brazil) as input to generate clear, qualified, personalized, and safe instructions for the citizens who will use the medication. It does not address diagnostic or prescription errors, nor does it correct dosages, concentrations, routes of administration, etc. Expected results: The goal is to develop LLM prompts capable of delivering high-quality and safe textual instructions that effectively reduce miscommunications between patients and prescribers. This initiative is part of the larger scientific project: "Development and Evaluation of an Intelligent System for Generating Guidance on Safe, Accessible, and Culturally Adapted Medication Prescribing." Through this approach, we aim to support professionals in the primary care context by delivering e-prescription outputs that meet standards of efficiency and safety, catering to diverse patient needs and enhancing the reliability of health communication.
iPSC Midbrain differentiation in 96 well plates v1
Authors: Parfitt gustavo.parfitt , Coccia Elena
Published: June 2024

Midbrain differentiation protocol using spinner flasks.
Direct Detection of poliovirus and Nanopore Sequencing (DDNS) - Stool v2
Authors: Shaw Alex , Troman Catherine , Akello Joyce , Bujaki Erika , Majumdar Manasi , Fitz Shannon , Bellekom Ben , OToole Aine , not provided c.ansley , not provided rachel.colquhoun , not provided arshady , not provided khurshida , not provided alammu , Rambaut Andrew , Martin Javier , Grassly Nick
Published: June 2024

This protocol is an update from the protocol described in the paper "Rapid and sensitive direct detection and identification of poliovirus from stool and environmental surveillance samples using nanopore sequencing" by Shaw et al in the Journal of Clinical Microbiology (2020), DOI: 10.1128/JCM.00920-20 and is commonly known as Direct Detection of Poliovirus by Nanopore Sequencing (DDNS). The protocol aims to amplify the VP1 region of poliovirus through a semi-nested PCR using a pan-Enterovirus primer and polio specific primers followed by amplification of the VP1 region using a polio specific primer set. We use barcoded primers as this greatly simplifies the subsequent library preparation process. This protocol is for use with Oxford Nanopore kit14 chemistry ligation sequencing reagents and can be used with the MinION Mk1B or GridION sequencer. Within the protocol steps, quality control checks are included and follow the workflow set out in the document "Quality Control and Data Recording for DDNS".
Mouse Stereotaxic Surgery for Alpha Synuclein Pre-formed Fibrils (PFFs) Injection in the Dorsal Striatum v2
Authors: Kumar Sah Saroj , Biederer Thomas
Published: June 2024

This protocol outlines the procedures for conducting stereotaxic surgery in mice for intracranial injections of PFFs into the dorsal striatum of the mouse brain.
Results of venous resections and reconstructions in retroperitoneal tumors
Authors: Katelnitskaya O. V. , Kit O. I. , Ausheva T. V. , Saforyan N. S.
Published: June 2024

Background. Retroperitoneal tumors are rare, heterogeneous malignant neoplasms. Due to the low sensitivity of tumor to chemoradiation, surgical resection is the only curative treatment method for retroperitoneal sarcomas. Performance of radical surgery improves the outcome for these patients. There are little data about the results of the treatment of the patients who underwent en bloc resection of the retroperitoneal tumors combined with the resection of large vessel.

Aim. To analyze surgical and oncological outcomes of treatment retroperitoneal neoplasms with vascular involvement. 

Materials and methods. From 2019 to 2022, 27 patients with retroperitoneal sarcomas underwent surgical treatment with the resection of large vessels during the period.

Results. The average diameter of the tumors was 17 (11–39) cm. The most common histological type was moderately differentiated liposarcoma (33.4 %), followed by pleomorphic liposarcoma (22.2 %), highly differentiated (18.5 %), undifferentiated sarcoma (18.5 %), leiomyosarcoma (7.4 %). Resection of the suprarenal segment of the inferior vena cava (IVC) with prosthetics was performed in 4 cases, resection of the renal segment with renal vein reimplantation – in 1 case, resection of the infrarenal segment of the IVC with prosthetics – in 8 cases. A synthetic prosthesis was used as a conduit in all cases. Tangential resection of the suprarenal IVC portion was performed in 1 patient, infrarenal portion – in 5 patients. A resection of the infrarenal IVC portion was performed without reconstruction in 1 case. Resection of the iliac vein was required in 6 patients; in one case the resection of the arterial iliac segment and prosthetics was added. Complete resection (R0–R1) was achieved in 85.2 % of the cases. The incidence of postoperative complications went as far as 25.9 % with no postoperative mortality. Despite ongoing anticoagulant therapy, the frequency of thrombosis in venous reconstruction zone in the early postoperative period (1 month) was 7.4 %. The median relapse-free survival was 16 months, and the median of overall survival was not achieved.

Conclusion. Combined operations with the excision of retroperitoneal malignancies and angioplasty have explicitly acceptable level of postoperative complications and mortality. Eradication of retroperitoneal tumor with large vessels invasion allows to enlarge the life expectancy of patients often considered to be inoperable.
Acute promyelocytic leukemia presenting with basophilia: diagnostic features and clinical observation
Authors: Akezheva K. A. , Aleshina O. A. , Vasileva A. N. , Dvirnyk V. N. , Ershov A. A. , Obukhova T. N. , Kovrigin A. M. , Troitskaya V. V.
Published: June 2024

Acute promyelocytic leukemia (APL) is a blood tumor characterized by aggressive clinical progression with characteristic clinical and laboratory signs (typical tumor cell morphology, severe hemorrhagic syndrome, hemorrhages with hematoma formation, excessive fibrinolysis, disseminated intravascular coagulation syndrome) but modern approaches to therapy potentially make this disease fully curable. APL is considered one of the most studied subtypes of acute leukemia and is characterized by abnormal proliferation of promyelocytes in the bone marrow. The morphologic picture of APL is quite diverse, but an increased basophil count represents a rare manifestation that requires further study and understanding of its significance. Currently, there are limited scientific data on the clinical course and response to standard therapy in patients with APL presenting with basophilia.
Sentinel lymph node mapping in patients with uterine cancer: current state of the problem. Literature review
Authors: Polovodova V. V. , Verenikina E. V. , Menshenina A. P. , Zhenilo O. E. , Ardzha A. Yu. , Rogozin M. A. , Abdullayeva N. M. , Shevchenko A. N. , Dimitriadi S. N.
Published: June 2024

Uterine cancer is one of the most common malignant diseases among female population. Surgical treatment is the main part of therapy but the question of lymph node dissection volume in patients with intermediate risk of uterine cancer metastasis remains open.

The article considers the concept of sentinel lymph node, anatomical characteristics of uterine lymphatic system. Description of various techniques for identification of sentinel lymph nodes, as well as clinical trial data evaluating their diagnostic effectiveness and sensitivity, are presented. Comparative analysis of the techniques and their combinations, drug administration routes is performed.
Anxiety and depression in patients with post-COVID-19 comorbities
Authors: R. da Rocha Maria Debora , T. N. D. Rodrigues Isabeli , C. Santos Sandra Virgínia , P. Santos Thalyta Cibele , S. Santos Pammela Weryka , C. Gomes Paulo Roberto , A. Hazime Fuad , S. Cardoso Vinicius
Published: June 2024

Background: The COVID-19 pandemic has brought significant impacts on mental health, increasing conditions such as anxiety and depression. The negative impact was even bigger among the population with chronic illnesses like diabetes, hypertension, and obesity. Fear of contamination, social isolation, lack of medical follow-up, and changes in lifestyle have contributed to the worsening of these disorders. Objective: The aim of this study was to assess anxiety and depression levels and quality of life in individuals with pre-existing comorbidities post COVID-19. Methods: This is a cross-sectional study with a descriptive and analytical approach. The study included 125 individuals divided in healthy group and chronically ill group. Behavioral and clinical characteristics were evaluated, such as physical activity after COVID-19, smoking, alcohol consumption, pre-existing comorbidities, and symptoms of anxiety and depression. Results: The study highlighted that the patients with diabetes and hypertension suffered the most from anxiety and depression possibly due to the higher susceptibility to coronavirus infection and the negative impact of these pre-existing conditions on mental health. In hypertensive individuals, the complex interaction between emotional stress, anxiety, and cardiovascular system dysregulation contributed to increased levels of anxiety and depression. Obesity, besides a risk factor for severe COVID-19, it also negatively impacted the immune system and had adverse effects on mental health, with an increase in depressive and anxious symptoms. Conclusion: This study emphasizes the need of special care to at-risk groups to minimize adverse impacts on mental health and improve the quality of life of individuals with pre-existing comorbidities post COVID-19.
Digital Nudge and Normality of Decision Making in Digital Healthcare
Authors:   Research Institute For Life And Culture Sogang University, Ryu Jaehan
Published: June 2024

In digital healthcare based on healthcare big data, digital nudges are gaining importance and a key role in bioethics. This situation raises new ethical issues, such as: can individuals using digital nudges provided by digital healthcare enhance their autonomy in decision-making? Can individuals be free from external micro-interference in the form of digital nudges? To what extent can individuals be allowed the freedom to participate in the design of precision medicine? Furthermore, the traditional norms and values of individual autonomy, justice, the common good, etc. that have been addressed in bioethics are not appropriate for the new context, so there is a need to reconceptualize existing concepts, especially the concept of autonomy in relation to decision-making. This reconceptualization should have a systematicity that can give timely practicality to the moral issues that may arise in situational contexts, especially in digital healthcare based on personalized medicine. Therefore, the purpose of this paper is to explore the normativity or approach of decision-making that is appropriate for the ethics of digital nudges to address the above emerging ethical issues.
Koreans' View of God Through Phenomenological Methods
Authors:   Research Institute For Life And Culture Sogang University, Hwang Gyeongsun
Published: June 2024

Western civilization developed in a scheme of confrontation and discrimination. The ontological constellation that has become a global destiny with the spread of Western power is fundamentally rooted in the masculine and patriarchal view of God in the West. Therefore, the salvation on which our future depends will be accomplished with the change of the view of God. And the new view of God that is to be sought should be one that harmonizes all kinds of conflicts such as God and nature, nature and man, man and woman. This article aims to show that the new view of God that we are waiting for to arrive clearly appears in Korean ancient history and Donghak. The harmonization of impersonal universal divinity and personal supreme deity, as well as the ontological role of human beings as the center of this harmonization, are all emphasized in the doctrin of God of ancient times and Donghak. This article understands that the ancient viewpoint of God refers to that of the Donghak beforehand and the latter proves the former. We take the phenomenology of 'fact itself', especially the phenomenology used by Heidegger in his thoughts on Being as a method. The intention of this article is to reveal that the coming view of God that will be the foundation for opening a new world of coexistence and prosperity is at the same time the oldest one. Our attempt is made through phenomenological methods.
The Effect of Using Smart Application on Critical Literacy of Engineering Education Students
Authors:   Department of Electronics Engineering, Faculty of Engineering, Universitas Negeri Padang, Padang, Indonesia, Hidayat Hendra
Published: June 2024

The incorporation of technology into educational settings is going through a period of rapid expansion, which is being accompanied by the persistent growth of a variety of forms of media. The purpose of this research is to investigate, among students majoring in engineering at Padang State University, how the utilization of learning apps contributes to the enhancement of fundamental reading and writing abilities. Learning Readiness was included as an independent variable alongside Intrinsic Learning Motivation and Critical Literacy, and Information Literacy was taken into consideration as a moderating variable. The present study involved the collection of a representative sample comprising 899 respondents. The collected data were subsequently subjected to analysis utilizing the Structural Equation Model (SEM). In this study we also conducted Fuzzy C-Means clustering, to see to what extent the value of each cluster can influence the others. The findings of this study indicate that individuals who have a high level of preparedness for learning and a strong sense of motivation are likely to achieve better outcomes. Additionally, possessing a proficient level of information literacy will exert an influence on the development of critical literacy.
Modeling deviations of object quality indicators from the norm
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences  St. Petersburg Institute for Informatics and Automation of the Russian Academy of Sciences, Mikoni S.V.
Published: June 2024

The concept of a norm on the scale of an object's quality indicator in the context of determining the most preferable object or its state is explored. The notions of permissible and maximum permissible deviations from the norm are uti-lized, with maximum permissible deviations defining the boundaries of the indicator scale. The fundamental version of the norm is represented as a segment on the indicator scale that excludes these boundaries. Point and semi-interval norms (“no more”, “no less”) are considered special cases of the interval norm, where the semi-interval norm reflects the alignment of the original interval norm's boundary with the indicator scale's boundary. For certain indicators, devia-tion in one direction from the norm is not only acceptable but also beneficial. An indicator satisfying this condition is termed optimized, while an indicator with undesirable deviations from both ends of the norm is termed neutral. In the model of belonging to the norm, three classes are distinguished: “norm”, “no more” and “no less” than the norm. Piecewise linear and nonlinear membership functions for these classes are proposed. In the nonlinear model, the boundaries of the interval norm are expanded to acceptable limits, leading to the intersection of membership functions of adjacent classes. Classification into these three classes is conducted separately for neutral and optimized indicators. Interpreting deviations from the norm, both unacceptable and acceptable, necessitates introducing two fictitious clas-ses: “worse than the norm” and “better than the norm.” These classes are formed from the “not less than” and “not more than” classes. To calculate the membership function for each class across all indicators, a weighted average func-tion is employed. Aggregated indices of belonging to the classes “norm,” “better than norm,” and “worse than norm” across all indicators are referred to as indices of stability, development, and deterioration of an object, respectively. These indices are used for a comprehensive assessment of the object, termed an indicator of its condition. An example of analyzing deviations from the norm, implemented in the modified SVIR-M selection and ranking system, is provid-ed.
Cognitive modeling of adaptive learning processes
Authors:   Samara University (Samara National Research University named after academician S.P. Korolev), Solovov A.V. , Menshikova A.A. ,   Samara University (Samara National Research University named after academician S.P. Korolev)
Published: June 2024

An approach to modeling adaptive learning processes using signed and weighted directed graphs (digraphs) is exam-ined. The vertices of the digraphs represent the characteristics of educational activities. The orientation, signs, and weights of the digraph arcs define the mutual influence of these characteristics. The dynamics of adaptive learning are modeled within digraphs using a specific impulse process algorithm. An external disturbance is introduced into a partic-ular vertex of the digraph, and the propagation of this impulse is analyzed, enabling the prediction of values at other vertices of the digraph. The problem of optimizing the weights of digraph arcs is formulated, and an algorithm for solv-ing it is proposed to achieve stability in the impulse process. Computational experiments on a digraph revealed that the objective function for optimizing the arcs of a weighted digraph is multiextremal. The occurrence of a local minimum is determined by the initial values of the vector of design variables (weights of digraph arcs) and constraints on these var-iables. Consequently, the qualifications of the developer of the adaptive learning model who assigns these values are crucial. Cognitive models of adaptive learning can be classified as prescriptive and descriptive. Prescriptive models out-line what the adaptive learning process should be, while descriptive models depict existing adaptive learning processes and can be utilized to study their effectiveness. The developed methodology for cognitive modeling of adaptive learn-ing processes allows for the prediction of learning outcomes and can be employed in the research, design, and imple-mentation of adaptation mechanisms and intelligent control in e-learning systems, as well as in the didactic training of teachers in the field of e-learning.
Подходы к автоматизации работ с онтологическими ресурсами
Authors:   Limited Liability Company the Pipeline Transport Institute, Shishenkov M.A.
Published: June 2024

Ontological models are extensively used in information support systems that offer resources and services for solving management, design, and scientific and technical problems. Specifically, domain ontologies are commonly utilized in decision support systems. In the ontological modeling of complex systems, there arises a need to automate the process-es of handling ontological resources. This work discusses the main software systems and methodologies for ontological modeling, approaches to automating the processes of creating, populating, and using ontological models, and considers the temporal aspect of the ontological representation of objects. The aim of the work is to explore methods for auto-mating the life cycle of ontological resources and to analyze the extent of their adaptation in applied ontologies. The work highlights a relatively high degree of automation in the process of populating ontologies and the use of large lan-guage models in this process. However, it points out the lack of methods for automating the conversion of information from tables and diagrams into ontological models, as well as for validating and processing the content of the model. Promising directions for automating work with ontological resources are also indicated.
The structure of the CDSS information repository based on the ontological approach
Authors:   Ufa University of Science and Technology, Bogdanova D.R. , Shakhmametova G.R. ,   Ufa University of Science and Technology, Niiazgulov A.M. ,   Ufa University of Science and Technology
Published: June 2024

The construction of an information repository for a clinical decision support system (CDSS) in the weakly formalized subject area of treating bronchopulmonary diseases is considered. An overview of approaches to creating knowledge bases in this subject area is provided. A method for extracting knowledge is described, which is based on rules from clinical recommendations and the search for dependencies between words in sentences, taking into account the se-quence of rule application. The information repository of the CDSS is populated with ontological and production knowledge bases using the proposed knowledge extraction method. An ontology for the selected subject area was de-veloped, and studies of its quality were conducted through an analysis of the graph topology using cognitive ergonom-ics metrics. The effectiveness of the described knowledge extraction method is demonstrated. An original architecture for a clinical decision support system has been developed.
Implementation of pharmacogenetics for treatment of patients with acute lymphoblastic leukemia
Authors: Graiqevci-Uka Violeta , Behluli Emir , Hadziselimovic Rifat , Liehr Thomas , Temaj Gazmend
Published: June 2024

Introduction: Acute lymphoblastic leukemia (ALL) is the most frequent pediatric leukemia; it can be defined according to chromosomic and genomic data. Cytogenetic analyses and determination of chromosomal numbers (such as hypo- or hyperdiploidy) and/or specific chromosomal rearrangements are basic for ALL classification and treatment. Even though cure rates of childhood ALL are at ~95%, pharmacogenetic aspects are of raising importance.
Material and Methods: We have analyzed the literature for ALL subtypes, corresponding therapy options, and pharmacogenetic implications.
Results: Data for ALL subtypes such as B-ALL, T-ALL, Ph-like ALL, DS-ALL, ETP-ALL, BCR-ABL1-like ALL are presented here. The gene polymorphism which lead to metabolizability of 6-MP are ITPA variants (94C>A) and IVS2+21A>C, in conjunction with TPMT (238G>C, TPMT*3B 460G>A and *3C 719A>G and NUDT15 (415C>T). For methotrexate metabolism gene polymorphisms are found for gene MTHFR as C677T and A1298C.
Conclusion: In the last decade in many hospital laboratories, pharmacogenetic aspects gain more and more importance. Application of many molecular biology methods provided progress in treatment and diagnosis of ALL patients. Combination therapy is proposed as an alternative to single drug treatments.
Text and Sound-Based Feature Extraction and Speech Emotion Classification for Korean
Authors: Jo Jaechoon , Kim Soo Kyun , Yoon Yeo-chan
Published: June 2024

Embracing the complexities of human emotions conveyed through speech, this study ventures into Speech Emotion Recognition (SER) within the human-computer interaction domain, leveraging cutting-edge artificial intelligence technologies. Focusing on the auditory attributes of speech, such as tone, pitch, and rhythm, the research introduces an innovative approach that amalgamates deep learning techniques with the A Learnable Frontend for Audio Classification (LEAF) algorithm and wav2vec 2.0 pre-trained on a large corpus, specifically targeting Korean voice samples. This methodology underlines the capacity of these technologies to process and decipher complex vocal expressions, aiming to elevate emotion classification precision notably. The exploration extends the horizons of SER by accentuating auditory emotion cues and aspires to enrich machine interactions to be more intuitive and empathetic across various applications like healthcare and customer service. The outcomes underscore the efficacy of transformer-based models, particularly wav2vec 2.0 and LEAF, in capturing the subtle emotional states expressed in speech, thereby affirming the importance of auditory cues over conventional visual and textual indicators. The study's implications for further research herald a promising trajectory for evolving AI systems adept at nuanced emotion detection, thereby forging pathways toward more natural and human-centric interactions between individuals and machines. This advancement is crucial for developing empathetic AI that can seamlessly integrate into our daily lives, understanding and reacting to human emotions in a way that mirrors human understanding and compassion.
Time-Series Data Augmentation for Improving Multi-Class Classification Performance
Authors: Kim Woo-Hyeon , Kim Geon-Woo , Ahn Jaeyoon , Chung Kyungyong
Published: June 2024

This paper proposes a new approach to classify and evaluate defects in concrete structures automatically. To overcome the limitations of defect detection methods that traditionally relied on expert visual observation, the reflection signal of electromagnetic pulses is extracted as time-series data and used to analyze the propagation characteristics of each defect. This study uses deep learning models to analyze these time-series data and classify defects. Since anomaly detection data has more normal data than anomaly data, data augmentation methods such as Time Warping, Noise Injection, Smoothing, Trend Shifting, etc., were applied to solve the problem of data imbalance and overfitting. Among them, Noise Injection showed the best performance. The generalization performance of the proposed method was evaluated through performance evaluation using LSTM, GRU, and TCN models, and LSTM models showed the highest performance. The study results show that the proposed method effectively classifies defect types in concrete structures and can solve the limitations of existing methods by automatic classification through deep learning models. In addition, it was confirmed that the model's performance could be improved by improving the amount and diversity of data by selecting and applying appropriate data augmentation methods. The contribution of the research is to present a new approach that automates the defect detection and classification task of concrete structures and provides high accuracy and efficiency.
Tax Control over Value Added Tax Transactions in the Digitalization Era
Authors:   Associate Professor of the Department of Financial, Banking and Customs Law Named after Professor Nina I. Khimicheva of the Saratov State Law Academy, PhD (Law), Associate Professor, Zhutaev Aleksey S.
Published: June 2024

The issue of tax evasion is quite common. At the same time, it is no secret that taxation plays a significant role in the economic security of the state. Value added tax has a huge role in the formation of the budget of the Russian Federation, however, the largest number of tax offenses is associated with it. This article is devoted to the tax control of value added tax operations, which is one of the main sources of budget revenues in most countries of the world.
Reimbursement of Expenses of an Intermediary Associated with Execution of an Order: Cost Criteria, Analysis and Identification of Tax Risks
Authors:   Lawyer at Kosenkov and Suvorov Law Firm, LLC, Glaschenko Vasily D.
Published: June 2024

The article makes an attempt at scientific systematization of criteria that expenses of an intermediary associated with execution of an order and recoverable in accordance with Clause 2, Art. 975, Art. 1001 of the Civil Code of the Russian Federation must meet for taxation purposes; the paper also attempts at singling out the related tax risks. In the opinion of the author of this article, meeting the proposed criteria will ensure legal certainty for economic entities taking part in intermediary relations and reduce the risk of potential disputes with the tax authority.
On the Role and Problems of Tax Incentives in the Development of the Radioelectronic Industry
Authors:   Associate Professor of the Department of Taxes and Tax Administration of the Financial University under the Government of the Russian Federation, PhD (Economics), Associate Professor, Tikhonova Anna V.
Published: June 2024

The article offers a systematization of instruments of the state financial support of radioelectronics. The author analyzes tax incentives for entities operating in the radioelectronic industry, identifies systemic drawbacks in tax incentives provided to the industry. The author suggests some ways of improvement of tax incentives in the final part of the study.