bluuebunny/crossref_metadata_2025 huggingface dataset:
Bladder diverticulum caused by primary bladder neck obstruction
Authors: Marantidis Joanna , Simhal Rishabh Kumar , Stamatakis Lambros , Sussman Rachael D
Published: February 2022

Here, we report a case of a patient in their mid 30s who presented with an elevated creatinine and was found to have a massive bladder diverticulum. The patient underwent a robotic-assisted diverticulectomy. They were later found to have a primary bladder neck obstruction on video urodynamics, and subsequently, underwent bladder neck incision, leading to significant improvement in urinary symptoms. Primary bladder neck obstruction is an overlooked cause of bladder diverticulum. While cystoscopy and cross-sectional imaging are frequently used in the initial evaluation of bladder diverticula, in the absence of an anatomic obstruction such as prostate enlargement, video urodynamics should be performed to assess for primary bladder neck obstruction.
Analysis on the Effect of the Rehabilitation Intervention-Centered Targeted Nursing Model on the Cardiac Function Recovery and Negative Emotions in Patients with Acute Myocardial Infarction
Authors: Wang Rong , Duan Gongxiang , Xu Huilan , Wu Yuanyuan , Su Yinhua , Li Jianzhi , Liao Li , Liao Daqi
Published: February 2022

Rehabilitation intervention which refers to the functional training by caregivers with the aid of specialized nursing techniques and the progressive promotion of patients’ training initiative, with the purpose of improving mobility and quality of life, is of great significance. The purpose of the study was to investigate the effect of the rehabilitation intervention-centered targeted nursing model on the cardiac function recovery and negative emotions in patients with acute myocardial infarction (AMI). A total of 120 AMI patients admitted to our hospital between January 2019 and January 2020 were selected as the study subjects and randomly divided into group A (n = 60) and group B (n = 60), in which the group B patients received routine nursing combined with rehabilitation intervention, while based on the treatment in group B, the patients in group A underwent rehabilitation intervention-centered targeted nursing model. Then, the cardiac function indexes, negative emotion score, levels of risk factors for heart failure, complication rate (CR), and the quality of life (QOL) of the patients were compared between the two groups. The cardiac function indexes of the patients after nursing in group A were significantly better than those in group B (

P
<
0.001

); the negative emotion scores of the patients after nursing in group A were significantly lower than those in group B (

P
<
0.001

); the levels of risk factors for heart failure of the patients after nursing in group A were significantly lower than those in group B (

P
<
0.001

); the CR of the patients in group A at 15 d and 30 d after admission was significantly lower than that in group B (

P
<
0.05

); the QOL scores of the patients after nursing in group A were significantly higher than those in group B (

P
<
0.001

). Rehabilitation intervention-centered targeted nursing model can optimize cardiac function, weaken the levels of risk factors for heart failure, reduce the incidence of complications, improve psychological conditions, and enhance the quality of life in AMI patients, which is worthy of application and promotion in clinical practice.
miR-103a-3p Silencing Ameliorates Calcium Oxalate Deposition in Rat Kidney by Activating the UMOD/TRPV5 Axis
Authors: Cui Zenglin , Li Yuwei , Liu Gaorui , Jiang Yanmeng
Published: February 2022

Maintaining the balance of calcium (Ca2+) metabolism in the kidney is crucial in preventing the formation of kidney stones. Functionally, the microRNA (miRNA) participating in this process needs to be unveiled. We induced NRK-52E cell injury by oxalate treatment. The role of transient receptor potential cation channel subfamily V member 5 (TRPV5) in oxalate-induced cells was studied by TRPV5 overexpression transfection, qRT-PCR, Western blot, MTT, and crystal adhesion detection. After identifying uromodulin (UMOD) expression in injured cells, we confirmed the interaction between TRPV5 and UMOD by coimmunoprecipitation (CoIP) and cell-surface biotinylation assays. The validation of UMOD-regulating TRPV5 in viability, crystal adhesion, and Ca2+ concentration of oxalate-induced cells was performed. Bioinformatics analysis and luciferase assay were used to identify the miRNA-targeting UMOD. The role of the miR-103a-3p-regulating UMOD/TRPV5 axis was detected by rescue experiments. We constructed a rat model with treatment of ethylene glycol (EG) to investigate the miR-103a-3p/UMOD/TRPV5 axis in vivo by hematoxylin-eosin (H&E) staining, Western blot, and immunohistochemistry (IHC). Upregulation of TRPV5 protected NRK-52E cells from oxalate-induced injury by enhancing cell viability and inhibiting CaOx adhesion. UMOD was depleted in oxalate-induced cells and positively interacted with TRPV5. UMOD silencing reversed the effect of TRPV overexpression on oxalate-induced cells. miR-103a-3p targeted UMOD and was mediated in the regulation of the UMOD/TRPV5 axis in oxalate-induced cells. Downregulating miR-103a-3p mitigated EG-induced CaOx deposition in kidney tissues in vivo by activating the UMOD/TRPV5 axis. miR-103a-3p silencing ameliorated CaOx deposition in the rat kidney by activating the UMOD/TRPV5 axis.
miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway
Authors: Xu Le , Zhang Yiming , Long Hua , Zhou Bo , Jiang Haibo
Published: February 2022

Background. Glaucoma is characterized by elevated intraocular pressure caused by aqueous outflow dysfunction. Trabecular meshwork plays a key role in controlling intraocular pressure by modulating aqueous outflow. This study investigated the protective effects of miR-486-5p in H2O2-stimulated human trabecular meshwork cells (TMCs). Methods. TMCs were disposed with 300 μM H2O2 to establish oxidative damage models in vitro. miR-486-5p mimics and its controls were transfected into TMCs, and cell apoptosis and extracellular matrix production (ECM) genes were measured by flow cytometry, western blotting, and immunofluorescence staining. Activities of superoxide dismutase (SOD) and malondialdehyde (MDA) were also assayed. Online tools and luciferase reporter assays were used to uncover the relationship between miR-486-5p and the TGF-β/SMAD2 pathway. Results. We found that H2O2-induced oxidative damage in TMCs and miR-486-5p was downregulated in H2O2-stimulated TMCs. Overexpression of miR-486-5p mitigated H2O2-induced oxidative damage by inhibiting apoptosis, reducing cleaved caspase-3/9 expression, reducing MDA levels, and increasing SOD levels as well as downregulating ECM genes. SMAD2 was demonstrated to be targeted by miR-486-5p, and miR-486-5p inhibited TGF-β/SMAD2 signaling in H2O2-stimulated TMCs. Additionally, SMAD2 was upregulated by H2O2, and SMAD2 upregulation abrogated the protective effects of miR-486-5p against H2O2-induced injury. Conclusion. miR-486-5p restrains H2O2-induced oxidative damage in TMCs by targeting the TGF-β/SMAD2 pathway.
Merkel Cell Carcinoma of the Left Eyelid with Metastasis to the Left Submandibular Lymph Nodes: A Case Report and Brief Review
Authors: Casey Caroline , Gallo Nina , Gallo Samuel
Published: February 2022

Merkel cell carcinoma (MCC) is a cutaneous cancer often found on sun-exposed areas. MCC is rare but very often lethal making early diagnosis challenging although critical. There are only a few cases that have reported MCC of the eyelid making it often hard to identify in clinic. A 52-year-old woman with a firm nodule on the left eyelid was diagnosed with MCC that had also metastasized to a left submandibular lymph node. She underwent surgical excision of the mass and lymph node as well as parotid gland and neck dissection to rule out other metastases and then underwent radiation therapy. The aim of this study is to report a case of eyelid MCC with metastasis to a local lymph node to provide another example of the rare cancer in hopes that diagnosis and treatment options for MCC are more thoroughly studied and understood.
CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts
Authors: Chen Yu-Hsiu , Zhang Xin , Ko Kuei-Yueh , Hsueh Ming-Feng , Kraus Virginia Byers
Published: February 2022

Cellular senescence is characterized by cell cycle arrest and senescence-associated secretory phenotypes. Cellular senescence can be caused by various stress stimuli such as DNA damage, oxidative stress, and telomere attrition and is related to several chronic diseases, including atherosclerosis, Alzheimer’s disease, and osteoarthritis. Chromobox homolog 4 (CBX4) has been shown to alleviate cellular senescence in human mesenchymal stem cells and is considered a possible target for senomorphic treatment. Here, we explored whether CBX4 expression is associated with replicative senescence in WI-38 fibroblasts, a classic human senescence model system. We also examined whether and how regulation of CBX4 modifies the senescence phenotype and functions as an antisenescence target in WI-38. During the serial culture of the WI-38 primary fibroblast cell line to a senescent state, we found increased expression of senescence markers, including senescence β-galactosidase (SA-βgal) activity, protein expression of p16, p21, and DPP4, and decreased proliferation marker EdU; moreover, CBX4 protein expression declined. With knockdown of CBX4, SA-βgal activity and p16 protein expression increased, and EdU decreased. With the activation of CBX4, SA-βgal activity, p16, and DPP4 protein decreased. In addition, CBX4 knockdown increased, while CBX4 activation decreased, gene expression of both CDKN2A (encoding the p16 protein) and DPP4. Genes related to DNA damage and cell cycle pathways were regulated by CBX4. These results demonstrate that CBX4 can regulate replicative senescence in a manner consistent with a senomorphic agent.
Rational Selection of Rail Transit Emergency Site Using Complex Network Topology and Genetic Algorithm
Authors: Zhou Jing , Shao Yunhong
Published: February 2022

Rail transit network is a convenient and reliable transportation mode in urban areas. With every surge in transportation demand, the network undergoes operational changes like restructuring and making of multiline tracks. Urban rail transit network is a complex network and needs proper emergency services and controlling mechanisms. Unexpected mishaps in rail transit will cause more hazard and panic than the other transportation systems. Therefore, a reliable emergency service station is required to ensure the safety and security of passengers. In the proposed method, the basic statistical properties of complex network topology are considered to construct a P-center site selection model for urban rail transit emergency service stations. The P-center site selection model is solved by genetic algorithm. Validity and reasonableness of the model are demonstrated by implementing it in the Hangzhou emergency service stations for rail transportation. The results show that the P-center site selection model based on statistical properties of complex network topologies can better solve the urban rail transit emergency service station site selection problems. The model minimizes the number of emergency service stations while satisfying the optimal objective function and reduces the construction cost of emergency service stations. The approach has a significant effect on improving system reliability and reducing the risk of emergencies.
Prognostic Value of Circulating Tumour DNA in Asian Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Authors: Liu Hongli , Yang Hong , Chen Xiaoliang
Published: February 2022

Background. Circulating tumour DNA (ctDNA) is a noninvasive method of detecting tumours, and its prognostic significance in hepatocellular carcinoma (HCC) patients is controversial. We conducted a systematic review of published research data to evaluate the prognostic value of ctDNA in HCC patients. Methods. The PubMed, Embase, Web of Science, Cochrane Library, and Scopus databases were searched to identify eligible studies reporting disease-free survival (DFS) and overall survival (OS) stratified by ctDNA prior to January 2022. We evaluated the quality and design of these studies. The hazard ratio (HR) was used to combine the survivorship curve and univariate and multivariate results of the included studies. Results. In total, 8 articles were included, encompassing 577 HCC patients. The results of survival curve analysis showed that ctDNA was related to poor OS and DFS, and the effect sizes were HR = 2.44, 95% CI (1.42, 4.20),

P
=
0.001

; HR = 2.63, 95% CI (1.96, 3.53),

P
<
0.001

. The univariate analysis results showed that ctDNA was related to poor OS (HR = 4.48, 95% CI (1.17, 13.70),

P
=
0.003

). The combined results of multivariate analysis showed that ctDNA was related to a shorter risk of OS (HR = 3.74, 95% CI (1.45, 9.65),

P
=
0.006

). The univariate and multivariate descriptive analysis results showed that ctDNA was related to shorter DFS, and the effect sizes were HR = 3.28, 95% CI (1.23, 11.30),

P
=
0.011

; HR = 3.01, 95% CI (1.11, 10.5),

P
<
0.001

. Conclusion. The evidence provided by this analysis suggests that ctDNA may be a prognostic biomarker and is negatively correlated with the survival of HCC patients. Mutations in the TERT and SOCS3 promoters in ctDNA are associated with poor prognosis and are expected to become good targets for liquid biopsy and to help select treatment strategies.
Refusal Strategies among Spanish-English Bilinguals: Comparing Adolescents with Hearing Loss to Adolescents with Typical Hearing
Authors: Gutiérrez-Rivas Carolina , Lim Stacey R. , Alfano Alliete Rodríguez
Published: February 2022

This study compares the sociopragmatic competence demonstrated by adolescents with hearing loss to that of adolescents with typical hearing raised in a bilingual Spanish-English context. We examine the speech act of refusals made by sixteen subjects, 12–19 years old, from the city of Miami, Florida. Eight of them were typically hearing. The other eight were diagnosed with bilateral severe to profound prelingual hearing loss before 2 ½ years of age and used spoken language as their primary method of communication. Our main objectives were: 1) to describe the preferred politeness strategies of these individuals while performing refusals in English and in Spanish; 2) to assess the degree of (in)directness with an interlocutor depending on power and distance; and 3) to determine if some pragmatic transfer occurs from one language to the other. The pragmatic abilities of both groups appeared higher in English than in Spanish, but it cannot be concluded that adolescents with hearing loss lack pragmatic abilities in either language.
Molecular phylogeny of Cousinia sections Albidae, Stenocephalae and Cousinia (Asteraceae): Systematic implications
Authors: KALOUTI SIMIN , KAZEMPOUR OSALOO SHAHROKH , ATTAR FARIDEH , SUSANNA ALFONSO , GARCIA-JACAS NÚRIA
Published: February 2022

Cousinia sect. Stenocephalae is a mainly Iranian section of the genus and the second largest section of Cousinia after C. sect. Cynaroidae. Its members are mainly distributed in Iran. Using nrDNA ITS sequences, together with morphological evidence where possible, we tested the monophyly of C. sect. Stenocephalae as well as the related C. sect. Albidae and C. sect. Cousinia. We reconstructed phylogenetic relationships within these sections by performing a Bayesian analysis on a sample of 153 species of Cousinia, of which 49 species belong to the study sections. The analysis revealed that C. sect. Stenocephalae, Albidae and Cousinia are not monophyletic, which lays stress upon the need of a deep reexamination of the sectional classification in Cousinia using a different approach.
A new species of the genus Thiodia Hübner, [1825] (Lepidoptera: Tortricidae) from South Kazakhstan
Authors: TSVETKOV EUGENE
Published: February 2022

Thiodia leucocitron sp. nov. is described from South Kazakhstan. Male and female genitalia of the species and habitus of imago are illustrated. The new species is well distinguished from the congeners by genitalia of both sexes. The description is based on material collected by the author in Karatau Mts. in 2019.
Deep Neural Network High Spatiotemporal Resolution Precipitation Estimation (Deep-STEP) Using Passive Microwave and Infrared Data
Authors: Gorooh Vesta Afzali , Asanjan Ata Akbari , Nguyen Phu , Hsu Kuolin , Sorooshian Soroosh
Published: February 2022

Recent developments in “headline-making” deep neural networks (DNNs), specifically convolutional neural networks (CNNs), along with advancements in computational power, open great opportunities to integrate massive amounts of real-time observations to characterize spatiotemporal structures of surface precipitation. This study aims to develop a CNN algorithm, named Deep Neural Network High Spatiotemporal Resolution Precipitation Estimation (Deep-STEP), that ingests direct satellite passive microwave (PMW) brightness temperatures (Tbs) at emission and scattering frequencies combined with infrared (IR) Tbs from geostationary satellites and surface information to automatically extract geospatial features related to the precipitable clouds. These features allow the end-to-end Deep-STEP algorithm to instantaneously map surface precipitation intensities with a spatial resolution of 4 km. The main advantages of Deep-STEP, as compared to current state-of-the-art techniques, are 1) it learns and estimates complex precipitation systems directly from raw measurements in near–real time, 2) it uses the automatic spatial neighborhood feature extraction approach, and 3) it fuses coarse-resolution PMW footprints with IR images to reliably retrieve surface precipitation at a high spatial resolution. We anticipate our proposed DNN algorithm to be a starting point for more sophisticated and efficient precipitation retrieval systems in terms of accuracy, fine spatial pattern detection skills, and computational costs.
Union Democracy, Union Bureaucracy, and the Left
Authors: Devinatz Victor G.
Published: February 2022

To have healthy union democracy, it is essential for the Left to be active in unions. Leftist unions are more democratic than non-leftist unions on all measures of union democracy including the absence of union corruption, the quantity of union factions, the presence of grassroots militancy, and union member participation in social movement unionism and community unionism. Additionally, although union democracy is associated with union effectiveness, restrictions on union democracy and decisions implemented by the union bureaucracy might be advantageous to the union as an organization in certain situations. If the survival of the union as an organization is at stake, it will be necessary for the union bureaucracy to make decisions, independent of rank-and-file union members. Although potentially denoting an infringement on union democracy, such decisions might aid the union as an organization, especially with the existence of a progressive union bureaucracy.
Base drag estimation in suddenly expanded supersonic flows using backpropagation genetic and recurrent neural networks
Authors: Quadros Jaimon D , Prashanth Thalambeti , Khan Sher A
Published: February 2022

In recent years, base pressure management has gained a lot of industrial importance due to its applications in missiles and projectiles. For certain aerodynamic vehicles, the base pressure becomes a critical factor in regulating the base drag. That prompted the current work to develop input–output relationships for a suddenly expanded flow process using experiments and neural network-based forward and reverse mapping. The objective of forward mapping (FM) is to predict the responses, namely base pressure (β), base pressure with cavity (βcav), and base pressure with rib (βrib), for a known combination of flow and geometric parameters, namely Mach number (M), nozzle pressure ratio (η), area ratio (α), and length to diameter ratio (ψ). On the other hand, an effort is made to decide the optimal set of flow and geometric parameters for achieving the desired base pressure by reverse mapping (RM). Neural network-controlled backpropagation and recurrent and genetic algorithms have been employed to carry out the forward and reverse mapping trials. A batch mode of training was employed to conduct a parametric study for adjusting and optimizing the neural network parameters. Due to the requirement of massive data for batch mode training, the data required for training was achieved using the response equations developed through response surface methodology. Further, the forecasting performances of the neural network algorithms are compared with the regression models (FM) and among themselves (RM) through random test cases. The findings indicate that all evolved neural network (NN) models could make accurate predictions in both forward and reverse mappings. The results obtained would help aerodynamic engineers control various parameters and their values that affect base drag.
Exclusive use of the second language in classroom interaction in English Medium Instruction science classrooms: the beliefs of students and their monolingual teachers
Authors: An Jiangshan , Macaro Ernesto
Published: February 2022

Previous research on English Medium Instruction classrooms has almost exclusively documented the interaction between a teacher and students where the teacher is able to understand and use the first language (L1) of the students. We present data obtained from science classrooms in English-medium-instruction (EMI) high-school programs in China where the teacher had almost no L1 proficiency and therefore spoke only English in class. The beliefs of both teachers and students were elicited with regard to L2-only English use in classroom interaction through questionnaire and post-lesson interviews with references to lesson observations. Two hundred and thirty-one questionnaires were collected, together with 60 interviews with students and teachers following 30 lesson observations. Our findings suggest that teachers divided into three categories of beliefs: virtual position, maximal position, and optimal position (already identified in previous literature), but that students tended to prefer a classroom environment in which some L1 was permitted, or even encouraged, in order to facilitate their understanding of complex science constructs. With increasing teacher mobility and a growing demand of EMI education worldwide, pedagogical suggestions are made to EMI programs with monolingual teachers.
Langerhans cell histiocytosis developing acute lymphoblastic leukemia
Authors: Zhang JinFang , Zong Sa , Liao Bing
Published: February 2022

The sequential occurrence of Langerhans cell histiocytosis and acute leukemia in only one individual has been reported previously; however, it is rarely observed that Langerhans cell histiocytosis can transform into acute lymphoblastic leukemia, and the underlying mechanisms remain unclear. In this report, we have analyzed a case of acute lymphoblastic leukemia converted from Langerhans cell histiocytosis using high-throughput sequencing method, and found that mitogen-activated protein kinase gene mutation, which can act as a marker for poor prognosis, might be involved in disease transformation. This is the first description about acute lymphoblastic leukemia B-cell type after Langerhans cell histiocytosis diagnosis and therapy in China.
A microsimulation of spatial inequality in energy access: A bayesian multi-level modelling approach for urban India
Authors: Neto-Bradley André P , Choudhary Ruchi , Challenor Peter
Published: February 2022

Access to sustained clean cooking in India is essential to addressing the health burden of indoor air pollution from biomass fuels, but spatial inequality in cities can adversely affect uptake and effectiveness of policies amongst low-income households. Limited data exists on the spatial distribution of energy use in Indian cities, particularly amongst low-income households, and most quantitative studies focus primarily on the effect of economic determinants. A microsimulation approach is proposed, using publicly available data and a Bayesian multi-level model to account for effects of current cooking practices (at a household scale), local socio-cultural context and spatial effects (at a city ward scale). This approach offers previously unavailable insight into the spatial distribution of fuel use and residential energy transition within Indian cities. Uncertainty arising from heterogeneity in the population is factored into fuel use estimates through use of Markov Chain Monte Carlo (MCMC) sampling. The model is applied to four cities in the South Indian states of Kerala and Tamil Nadu, and comparison against ward-level survey data shows consistency with the model estimates. Ward-level effects exemplify how specific wards compare to the city average and to other urban areas in the state, which can help stakeholders design and implement clean cooking interventions tailored to the needs of those households.
Synthesis of Optically Active V(120°)- and (60°)-Shaped Molecules Comprising Different π-Electron Systems
Authors: Tabata Daiki , Inoue Ryo , Sasai Yusaku , Morisaki Yasuhiro
Published: February 2022

Optically active V-shaped molecules were synthesized by exploiting chemoselective Sonogashira-Hagihara coupling using planar chiral pseudo-meta- and pseudo-ortho-disubstituted [2.2]paracyclophane scaffolds. In these scaffolds, different para-phenylene-ethynylene π-electron systems were stacked. The synthesized molecules emitted circularly polarized luminescence (CPL) with relatively high dissymmetry factors (glum values) at the order of 10−3. The CPL behaviors are controlled by the stacking angle, position, and manner of the two π-electron systems.
Μυοκαρδιακή ίνωση στις συγγενείς καρδιοπάθειες
Authors: Καραλή Κωνσταντινιά
Published: February 2022

Σκοπός της διατριβής ήταν η ανίχνευση και ποσοτικοποίηση της έκτασης της μυοκαρδιακής ίνωσης σε ασθενείς με διορθωμένη Τετραλογία Fallot καθώς και η συσχέτιση της ίνωσης με κλινικούς και απεικονιστικούς δείκτες, επίπεδα νεότερων βιοδεικτών ίνωσης καθώς και με ήδη γνωστούς βιοδείκτες καρδιακής ανεπάρκειας. Ποσοτικοποιήθηκε η μυοκαρδιακή ίνωση με τη χρήση μαγνητικής τομογραφίας καρδιάς και με την τεχνική καθυστερημένης πρόσληψης γαδολινίου. Όλοι οι ασθενείς υποβλήθηκαν σε ενδελεχή κλινικό και απεικονιστικό έλεγχο καθώς και σε καρδιοαναπνευστική δοκιμασία κόπωσης. Ακολούθως προσδιορίσθηκαν τα επίπεδα νεότερων βιοδεικτών ίνωσης αλλά και νευροορμονικής ενεργοποίησης. Συσχετίσθηκαν τόσο τα κλινικά και απεικονιστικά δεδομένα καθώς και δεδομένα μελέτης δυσυγχρονισμού μέσω καρδιακού μαγνητικού συντονισμού, καθώς και τα επίπεδα βιοδεικτών με την έκταση της μυοκαρδιακής ίνωσης. Εκτεταμένη μυοκαρδιακή ίνωση ανιχνεύθηκε κυρίως στις χειρουργικές θέσεις της δεξιάς κοιλίας, με σημαντική διάταση και δυσλειτουργία της ΔΚ. Μυοκαρδιακή ίνωση δεν ανιχνεύθηκε στην ΑΚ. Η έκταση της ίνωσης στην παρούσα μελέτη σχετίσθηκε με δυσμενή κλινική έκβαση, συμπεριλαμβανομένων πέραν της διάτασης και δυσλειτουργίας της ΔΚ και την έκπτωση της ικανότητας προς άσκηση. Aυξημένα επίπεδα του βιοδείκτη ίνωσης Galectin-3, θα μπορούσαν να χρησιμεύσουν στη μη επεμβατική εκτίμηση της υπερφόρτωσης όγκου λόγω μέτριας/σοβαρού βαθμού ανεπάρκειας πνευμονικής βαλβίδας σε ενήλικες με rToF. Επίσης. αύξηση των επιπέδων του δείκτη νευροορμονικής διέγερσης στην καρδιακή ανεπάρκεια NTproBNP, μπορούν να αντικατοπτρίσουν την έκταση της μυοκαρδιακής ίνωσης της ΔΚ. Στη μελέτης μας αποδείχθηκε πως η εκτεταμένη ίνωση της ΔΚ οδηγεί σε μειωμένη απόδοση της ΑΚ και πιθανή νευροορμονική ενεργοποίηση, ενδεικτική της ανεπιθύμητης προοδευτικής κοιλιο-κοιλιακής αλληλεπίδρασης.
Η επίδραση της άσκησης στα νευροψυχιατρικά συμπτώματα ασθενών με άνοια
Authors: Κουλουτμπάνη Κομάνθη
Published: February 2022

Η διαχείριση νευροψυχιατρικών συμπτωμάτων (ΝΨΣ) που εκδηλώνουν συχνά ασθενείς με άνοια αποτελεί σημαντική πρόκληση στην αντιμετώπιση της νόσου. Ειδικότερα, συμπτώματα, όπως ψυχοκινητική ανησυχία, απάθεια, άγχος, κατάθλιψη, ψευδαισθήσεις συνδέονται με χαμηλή ποιότητα ζωής, αύξηση της επιβάρυνσης των περιθαλπόντων, κακή πρόγνωση της ασθένειας, πρόωρη ιδρυματοποίηση και αυξημένο κίνδυνο θνητότητας. Δεδομένου ότι μέχρι σήμερα η κλινική διαχείριση των ΝΨΣ γίνεται κυρίως φαρμακευτικά και τα φάρμακα που χορηγούνται για τον σκοπό αυτό σχετίζονται με σημαντικές παρενέργειες, η ανάγκη εναλλακτικών μη-φαρμακευτικών παρεμβάσεων εμφανίζεται επιτακτική. Στο παραπάνω πλαίσιο αναφοράς, επιδίωξη της παρούσας διδακτορικής διατριβής ήταν ο συστηματικός προσδιορισμός της επίδρασης της σωματικής άσκησης στα ΝΨΣ της άνοιας. Για τον σκοπό αυτό εκπονήθηκε συστηματική ανασκόπηση της βιβλιογραφίας και μετα-ανάλυση των δεδομένων, σύμφωνα με τις κατευθύνσεις του «Preferred Reporting Items for Systematic Reviews and Meta-Analyses» (PRISMA). Η αναζήτηση της βιβλιογραφίας διεξήχθη σε πέντε ηλεκτρονικές βάσεις δεδομένων (SCOPUS, PubMed, SPORTDiscus, Web of Science και ScienceDirect) με τη χρήση του κατάλληλου αλγόριθμου. Αναζητήθηκαν τυχαιοποιημένες κλινικές δοκιμές οι οποίες: (α) είχαν εφαρμόσει παρεμβάσεις σωματικής άσκησης με συγκεκριμένα χαρακτηριστικά (δηλ. είδος, συχνότητα, ένταση και διάρκεια) σε ασθενείς με άνοια ή ήπια νοητική εξασθένηση, (β) μελέτησαν την επίδραση της άσκησης στα νευροψυχιατρικά τους συμπτώματα και (γ) σύγκριναν την επίδραση αυτή σε σχέση με μία ομάδα ελέγχου που δεν ακολούθησε κάποιο πρόγραμμα άσκησης. Από τις 512 καταχωρήσεις που εντοπίστηκαν, δεκατρείς μελέτες πληρούσαν τα προαναφερόμενα κριτήρια με συνολικό αριθμό συμμετεχόντων 1.846 άτομα. Δώδεκα από τις περιληφθείσες μελέτες μέτρησαν τη συνολική βαθμολογία των ΝΨΣ, οκτώ την κατάθλιψη και μία μελέτη τα συμπτώματα ψυχοκινητικής ανησυχίας. Οι μετα-αναλύσεις αποκάλυψαν ότι η σωματική άσκηση περιορίζει σημαντικά τη συνολική βαθμολογία των ΝΨΣ (διαφορά μέσων = -5,28, 95% CI = -9,46 έως -1,11, P = 0,01) και τα συμπτώματα κατάθλιψης (τυποποιημένη διαφορά μέσων = -0,16, 95% CI = -0,29 έως -0,02, P = 0,02). Επιπροσθέτως, στην παρούσα μελέτη παρατηρήθηκε θετική επίδραση στα συμπτώματα ψυχοκινητικής ανησυχίας. Αναφορικά με την αξιολόγηση της ποιότητας επιστημονικής τεκμηρίωσης των στοιχείων, η ανάλυση «Grading of Recommendations, Assessment, Development and Evaluation» (GRADE) αποκάλυψε υψηλή βεβαιότητα για τα αποτελέσματα όσον αφορά την επίδραση της άσκησης στα συμπτώματα κατάθλιψης και μέτρια βεβαιότητα όσον αφορά τα ΝΨΣ συνολικά. Συνοψίζοντας, υπάρχουν ισχυρές ενδείξεις ότι η σωματική άσκηση αποτελεί μία πολλά υποσχόμενη εναλλακτική προσέγγιση στη μη φαρμακευτική αντιμετώπιση της άνοιας, καθώς μπορεί να είναι αποτελεσματική στη διαχείριση των ΝΨΣ. Ωστόσο, απαιτείται η εφαρμογή σαφών πρακτικών συστάσεων και ειδικά σχεδιασμένων προγραμμάτων, ώστε η σωματική άσκηση να ενταχθεί στο καθημερινό πρόγραμμα των ασθενών.
Shifting the distribution curve for healthcare resource use through topical oxygen therapy for wound healing
Authors: Alves Paulo , Elg Fredrik , Bothma Gerhard , Oliveira Ana , Neves-Amado João , Amado João
Published: February 2022

The clinical and economic burden associated with hard-to-heal wounds is high and evidence suggests that it continues to increase. Healthcare resources consumed during the provision of wound care can be saved by implementing strategies and actions aimed at promoting wound healing. When these are successful, the frequency distribution curve for time to healing and for the consumption of healthcare resources should ‘move to the left’ and the extent to which it is ‘skewed to the right’ would be reduced, resulting in a reduction in the population mean for time to wound healing, and correspondingly, healthcare resources. Not only would this release healthcare resources in the short term, but, if these changes are maintained, would render savings sustainable, thereby contributing to lowering the overall burden of wounds and wound care. In this article, we present evidence that suggests that the adoption of adjunct topical haemoglobin spray can effect these desired changes in the wound healing curve and, due to the nature of the technology, it can be easily and sustainably implemented within relevant whole populations requiring wound care. The ease of adoption and impact is further illustrated by a patient case study.
Специфика русских литературно-художественных журналов
Authors: Grushina Natalia
Published: February 2022

Настоящая статья посвящена уникальному типу издания, оказавшему огромное влияние на формирование, развитие и мировоззрение российской интеллигенции. С середины 19 века литературно-художественные журналы в России заняли особое место в ряду различных периодических изданий. Так называемые «толстые журналы» в разные периоды российской истории не только влияли на развитие общественно-политической мысли, но и формировали свободолюбивое мировооззрение своего читателя. В статье рассматривается специфика «толстых журналов» как особого типа периодических изданий, повествуется об основных вехах в истории данного типа издания, предлагается новый метод изучения языка литературно-художественных журналов как единого дискурса.
Copi y el teatro camp: el acto de vestir y desvestir como una ontología de la identidad en la obra teatral Eva Perón
Authors: Macías Sergio A.
Published: February 2022

La obra literaria del escritor y dramaturgo franco-argentino, Raúl Damonte Botana (1939-1987) —mejor conocido por el pseudónimo de Copi—, ha despertado opiniones divididas entre la crítica literaria. Quienes se han ocupado de analizar la narrativa y el teatro de Copi argumentan que sus creaciones gestan en el lector cierta impresión de desasosiego al enfrentarse a un universo narrativo caótico y excesivo, plagado de incongruencias y personajes siniestros. Si bien es cierto que el teatro de Copi puede conceptualizarse como un esfuerzo, quizás fallido, que pretende romper con toda escuela, influencia o tradición, existen también una serie de elementos distintivos en el teatro de Copi que nos permite examinar sus obras bajo la óptica del camp —un tipo de sensibilidad asociada con la identidad queer que se caracteriza por ser frívolo, extravagante, pretencioso, incongruente, además de exhibir una fascinación por el disfraz y la ornamentación estética; pero en el fondo, representa un gesto genuino a través del cual se revela una verdad. Como estrategia, el camp nos brinda una novedosa propuesta que nos permite reconocer el valor de las inusuales creaciones de Copi, más allá de catalogar el teatro de Copi como un caso accidental o aislado. Para lograr este cometido analizo Eva Perón, la cual nos presenta una Eva Perón drag queen y desmesurada, muy al estilo camp, obsesionada con la moda y sus extravagantes vestidos. Propongo además que en la obra teatral Eva Perón, Copi nos brinda a los espectadores un tratado ontológico en el que la identidad es planteada esencialmente como un ornamento estético, vestimenta o disfraz, y el ser queda manifestad a través del acto de vestir y desvestir. En el presente estudio, primero, exploro las definiciones del camp y trazo una breve historiografía para enfocarme después en el llamado teatro camp. Posteriormente, analizo la puesta en escena de Eva Perón centrándome en las recurrentes referencias estéticas en torno a la creación de la identidad.
El eportfolio una herramienta para la evaluación del desarrollo profesional docente
Authors: Martínez De la Muela Alicia , Arteaga Martínez Blanca , García García Mercedes
Published: February 2022

El interés para determinar un proceso de evaluación del desarrollo profesional de los docentes ha cobrado especial interés en las últimas décadas por considerarse un factor de eficacia de los sistemas educativos. El hecho de que se constituya como un proceso continuo nos lleva a un planteamiento evaluador que toma como indicador la autopercepción de un conjunto de competencias genéricas ligadas a la mejora (reflexiva, autonomía, razonamiento crítico y trabajo equipo).Este estudio utiliza la herramienta digital eportfolio con una muestra de docentes (n=306) de educación obligatoria en dos cursos de formación. Los análisis cuantitativos y cualitativos permiten concluir que el eportfolio es útil en el desarrollo profesional porque facilita la reflexión crítica; sin embargo, no se obtienen mejoras significativas en la percepción de las competencias de autonomía y trabajo en equipo. Estos resultados nos llevan a plantear una propuesta de intervención en la elaboración y uso de la herramienta eportfolio en la formación docente.
Un sistema de actividad para la diagramación argumental con TIC: ¿podemos hablar de innovación educativa?
Authors: Ferrero Federico , Gewerc Adriana
Published: February 2022

El Enfoque Sociocultural de los aprendizajes entiende que todo sistema de actividad se transforma cuando así lo hacen su objeto y su motivo. A partir de allí, este artículo analiza la dinámica de constitución, desarrollo y posible transformación de un sistema de actividad de diagramación argumental que utiliza el software Araucaria en clases de Lógica Informal (Facultad de Filosofía y Humanidades, FFyH, Universidad Nacional de Córdoba, UNC, Argentina). Desde una metodología mixta, se aborda un estudio de caso en el cual se realiza observación no participante durante un semestre. Los resultados sugieren que Araucaria  promueve el aprestamiento técnico y la eficiencia en la manipulación diagramática, aunque no se observan indicios de transformación del contenido a aprender. Solamente se advierte el traslado de un sistema diagramático clásico (arbóreo) a un entorno virtual, junto con el agregado de un nuevo conjunto de acciones independientes de las motivaciones que fundan el sistema de actividad “tradicional”.
La cientificidad del Trabajo Social.
Authors: Alvarado Guevara Rosa Acela Mayanix , Carrillo Montoya Teresita del Niño Jesús , Urrea Zazueta María Luisa
Published: February 2022

Este trabajo tiene como objetivo analizar la cientificidad del Trabajo Social. Se describen las temáticas y los enfoques teóricos-metodológicos de la producción científica que se divulga en revistas mexicanas de Trabajo Social. Asimismo, caracterizar a los/las autores/as que publican en ellas. El análisis se enmarca en los planteamientos teóricos que evidencian la evolución del Trabajo Social y el inherente debate entre la teoría y la práctica. Es un estudio mixto, de diseño secuencial por etapas. Se analizaron tres revistas mexicanas de Trabajo Social. Además, se administró una entrevista semiestructurada a siete expertos/as: dos presidentes/as de asociaciones de investigación, tres editores/as de revistas y dos responsables de redes en la misma disciplina. Los resultados revelan que los artículos publicados tienden hacia el estudio de las problemáticas sociales, el uso del enfoque hermenéutico y abordaje cualitativo. En esas revistas publicant más profesionales de otras áreas que trabajadores/as sociales, y solo de universidades iberoamericanas. Se concluye que los/las trabajadores/as sociales necesitan asumir una cultura por la producción científica.
“Al inicio creía que el problema era yo”.
Authors: El Jebary Amisaou Cheima , El Mouali Samadi Fatiha
Published: February 2022

El acceso de las personas racializadas al mercado laboral calificado en España continúa siendo un hecho anecdótico. Son pocas las personas que han podido superar las trabas burocráticas y el estigma social para acceder a un puesto de trabajo. Y menos aún, en instituciones públicas o del tercer sector que reconozcan su formación profesional y preparación académica. En este artículo analizamos algunos aspectos que caracterizan la relación que se constituye entre el personal profesional autóctono y el racializado que se da en el espacio laboral. El enfoque metodológico adoptado se centra en el relato biográfico y la auto etnografía puesto que se parte de las experiencias de las propias autoras, buscando de esta manera visibilizar y poner en debate unas experiencias vividas, pero silenciadas hasta el momento. Los resultados muestran cómo las intervenciones sociales realizadas por profesionales racializados/as se ven constantemente reducidas al prisma de su origen y supuesta cultura, para resolver únicamente situaciones que no están al alcance del/la profesional autóctono. El background de los/las profesionales racializados/as se ve menospreciado e instrumentalizando durante la intervención social. Consecuentemente, el espacio laboral, se vuelve un entorno inseguro, lleno de miradas sospechosas, problematizando la presencia e ignorando las capacidades y habilidades de los/las profesionales racializados/as.
A Oficina de Camões: Apontamentos sobre Os Lusíadas
Authors: Bernardes José Augusto Cardoso
Published: February 2022

Após 450 anos da publicação (assinalados em 2022), Os Lusíadas justificam uma revisitação crítica. É esse o propósito deste volume. Feito a partir de estudos antes publicados em revistas ou volumes coletivos, mas agora reelaborados no conteúdo e na forma, o livro visa proporcionar uma visão global e atualizada da epopeia camoniana. Pela sua preocupação pedagógica, via alcançar um público mais amplo, incluindo estudantes e agentes de ensino.
WHOLESALE MARKET OF ELECTRICITY AND POWER AS RESULT OF RAO UES REFORM (ON THE EXAMPLE OF ALTAI KRAI)
Authors: Yashchenko A. V.
Published: February 2022

The article examines the specific structures and mechanisms of power supply to consumers that have developed as a result of the so-called market transformations of RAO UES of Russia. Reforms, conceived as market reforms, in fact, ended up as a conglomeration of administrative and bureaucratic structures and certain principles, rules and procedures that vaguely resemble market relations. In fact, the transformation of the electric power industry was forced to take into account the anti-market nature of its functioning: first, technological (specificity of the product and the industry); second, organizational and administrative, requiring a special organization, which is fundamentally different from the traditional market for goods and services. Therefore, the transformation of the electric power industry, carried out by the method of trial and error, has gone through a rather difficult path of registration, re-registration, change of the legal status of market participants. Almost all the processes of buying and selling electricity and capacity are surrounded by numerous rules, restrictions, institutions that have nothing to do with the market. This concerns the choice of counterparties, electricity payment processes and especially capacity, when the consumer pays in advance for the goods that were not actually purchased from the supplier.
Bacteriemia por enterobacterias productores de β-lactamasas de espectro extendido, en una unidad de cuidado intensivo pediátrico: serie de casos
Authors: Palacios Ariza Maria Alejandra , González-Cruz Jhon Alejandro , Pedraza-Aldana Andrés Fabian , Gutiérrez-Tobar Iván Felipe
Published: February 2022

Introducción: la prevalencia de bacteriemias causadas por gérmenes productores de β-lactamasas de espectro extendido en niños ha aumentado a nivel mundial, al igual que sus complicaciones y costos. Objetivo: caracterizar la infección por enterobacterias productoras de β-lactamasas de espectro extendido en la población pediátrica hospitalizada en unidad de cuidado intensivo. Métodos: se llevó a cabo un estudio descriptivo retrospectivo, identificando pacientes hospitalizados en una unidad de cuidado intensivo pediátrico con reporte de hemocultivos, durante enero de 2016 hasta diciembre de 2019. Resultados: se revisaron 1 638 historias. En once casos (0.67 %) se evidencio al menos un cultivo positivo para enterobacterias productoras de β-lactamasas de espectro extendido. Ninguna infección fue asociada al cuidado de la salud. Todos los sujetos tuvieron fiebre, con una temperatura mediana de 39°C (Rango intercuartílico de 0.2). El germen aislado con mayor frecuencia fue E. coli, seguido de K. pneumoniae. Los reactantes de fase aguda como la proteína C reactiva, la velocidad de sedimentación globular y la procalcitonina presentaban valores por encima del límite superior normal. El tratamiento antibiótico fue pertinente en la totalidad de los casos y solo se requirió cambio de antibiótico en un caso por no respuesta. Conclusiones: este estudio reunió datos locales que permiten sentar la línea de base de esta condición. Se generaron recomendaciones clínicas adicionales que pueden mejorar los desenlaces en población pediátrica.
REKONSTRUKSI KEDUDUKAN ANAK AKIBAT PERKAWINAN SIRRI PASCA PUTUSAN MAHKAMAH KONSTITUSI DENGAN PENDEKATAN HUKUM PROGRESIF
Authors: Supriyadi Supriyadi
Published: February 2022

Putusan Mahkamah Konstitusi dalam perkembangannya tidak efektif dalam implementasinya. Untuk itu perlu direkonstruksi agar dapat memberikan kepastian hukum yang berkeadilan. Penelitian ini merupakan penelitian yuridis normatif  dengan menggunakan data sekunder yang dianalisis secara kualitatif dengan pendekatan hukum progresif. Kesimpulan dalam penelitian ini adalah dalam hukum progresif anak yang lahir akibat perkawinan sirri mempunyai kedudukan yang berbeda dengan anak luar kawin lainnya. Bentuk perlindungan hukum dapat berupa pencatatan secara administratif dan hak-hak lain yang berkaitan dengan nasab, kewarisan, wali nikah, nafkah dari ayahnya.
(Trans)narodowe podróże. Na przykładzie wybranych utworów prozatorskich Andrzeja Stasiuka
Authors: Iwasiów Sławomir
Published: February 2022

Celem artykułu jest przedstawienie podróżniczych wątków w twórczości Andrzeja Stasiuka na tle teorii Jahana Ramazaniego, amerykańskiego literaturoznawcy z University of Virginia, autora książki A Transnational Poetics (2009). Teoria Ramazaniego daje się streścić w następujący sposób: sensem literatury jest podróżowanie, a utwory – przede wszystkim poetyckie – posiadają cechy podobne do podróży, są dynamiczne, zmienne, przekraczają granice. W takiej perspektywie samego Andrzeja Stasiuka – autora prozy podróżniczej – można przedstawić jako pisarza (trans)narodowego, specyficznego, ale równocześnie uniwersalnego. Gdyby trzeba było ułożyć (trans)narodowy kanon literacki, to Stasiuk mógłby reprezentować obszar kultury polskiej.
Cardano and Scaliger in Debate on the Revival of Ancient Music
Authors: Prins Jacomien
Published: February 2022

The rediscovery of ancient ideas about the power of music inspired Renaissance scholars to formulate a tantalizing view of the restoration of the wonderful music of the ancient Greeks. But from the start of this revival, skeptical voices questioned the feasibility of any attempt to establish a historically informed music practice. This article explores the changing status and authority of classical music-theoretical sources in sixteenth-century Italy by analyzing the famous debate between Girolamo Cardano and Julius Caesar Scaliger on ancient ideas about sound, hearing, and the power of music. Both voices mark a pivotal early stage in the emergence of early modern musical science, in which scholars began to study musical phenomena in accordance with a new philosophy of nature but had no established research agenda upon which to rely when doing so. Their attempts to theorize, in terms of natural phenomena, the seemingly inexplicable musical wonders recounted in traditional sources demonstrate that the tradition of Pythagorean and Platonic mathematics could not be easily discarded in the mid-sixteenth century. Cardano and Scaliger inspired later generations of scholars to formulate new theories in which music was valued less for its numerical perfection and supernatural power than for its sensory qualities and natural effect on the passions of the soul—ideas that would come to underpin the development of acoustics and music aesthetics in later centuries.