bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients
Authors: Siwaponanan Panjaree , Siegers Jurre Ynze , Ghazali Razi , Ng Thian , McColl Bradley , Ng Garrett Zhen-Wei , Sutton Philip , Wang Nancy , Ooi Isabelle , Thiengtavor Chayada , Fucharoen Suthat , Chaichompoo Pornthip , Svasti Saovaros , Wijburg Odilia , Vadolas Jim
Published: March 2017

Key Points

Aberrant neutrophil maturation is associated with reduced effector functions in β-thalassemia. PU.1, the key regulator of terminal neutrophil maturation, is dysregulated in β-thalassemia.
Reflectance imaging spectroscopy and synchrotron radiation X-ray fluorescence mapping used in a technical study of The Blue Room by Pablo Picasso
Authors: Favero Patricia A. , Mass Jennifer , Delaney John K. , Woll Arthur R. , Hull Alyssa M. , Dooley Kathryn A. , Finnefrock Adam C.
Published: March 2017

The existence of a portrait hidden beneath The Blue Room (1901) by Pablo Picasso prompted a comprehensive technical study of this early Blue period painting. Microanalysis of paint samples was combined with reflectance imaging spectroscopy (RIS) and synchrotron radiation X-ray fluorescence (SR-XRF) mapping to characterize the materials and structure of the paint layers and to understand the artist’s palette and use of color in both paintings. Microanalysis of paint samples provided detailed information about pigment mixtures and paint stratigraphy while the complementary data sets provided by RIS and SR-XRF yielded important information about pigment distribution in both pictures and clarified details of the underlying painting. Overall, the comprehensive study increased understanding of both pictures and added to the growing body of knowledge about Picasso’s early experimentation and evolving technique.
Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity
Authors: Zimmerman Robert , Tsai Amy G. , Salazar Vázquez Beatriz Y. , Cabrales Pedro , Hofmann Axel , Meier Jens , Shander Aryeh , Spahn Donat R. , Friedman Joel M. , Tartakovsky Daniel M. , Intaglietta Marcos
Published: March 2017

BACKGROUND:

Blood transfusion is used to treat acute anemia with the goal of increasing blood oxygen-carrying capacity as determined by hematocrit (Hct) and oxygen delivery (DO2). However, increasing Hct also increases blood viscosity, which may thus lower DO2 if the arterial circulation is a rigid hydraulic system as the resistance to blood flow will increase. The net effect of transfusion on DO2 in this system can be analyzed by using the relationship between Hct and systemic blood viscosity of circulating blood at the posttransfusion Hct to calculate DO2 and comparing this value with pretransfusion DO2. We hypothesized that increasing Hct would increase DO2 and tested our hypothesis by mathematically modeling DO2 in the circulation.

METHODS:

Calculations were made assuming a normal cardiac output (5 L/min) with degrees of anemia ranging from 5% to 80% Hct deficit. We analyzed the effects of transfusing 0.5 or more units of 300 cc of packed red blood cells (PRBCs) at an Hct of 65% and calculated microcirculatory DO2 after accounting for increased blood viscosity and assuming no change in blood pressure. Our model accounts for O2 diffusion out of the circulation before blood arriving to the nutritional circulation and for changes in blood flow velocity. The immediate posttransfusion DO2 was also compared with DO2 after the transient increase in volume due to transfusion has subsided.

RESULTS:

Blood transfusion of up to 3 units of PRBCs increased DO2 when Hct (or hemoglobin) was 60% lower than normal, but did not increase DO2 when administered before this threshold.

CONCLUSIONS:

After accounting for the effect of increasing blood viscosity on blood flow owing to increasing Hct, we found in a mathematical simulation of DO2 that transfusion of up to 3 units of PRBCs does not increase DO2, unless anemia is the result of an Hct deficit greater than 60%. Observations that transfusions occasionally result in clinical improvement suggest that other mechanisms possibly related to increased blood viscosity may compensate for the absence of increase in DO2.
Greeting the Dead
Authors: Allison Anne
Published: March 2017

At a moment when the population is declining, marriage and birth rates are down, one-third of people live alone while one-fourth are sixty-five or older, and reports of “lonely death” (of solitary people whose bodies are discovered days, or weeks, after death) are commonplace, the social ecology of existence is undergoing radical change in twenty-first-century Japan. While long-term bonds—to company, family, locale—were once the earmarks of its “group-oriented society,” today living and dying alone mark Japan’s new era of “single-fication” and “disconnected society” (muen shakai). How the rise of single-fication affects the management of death—both those already dead and those at risk of dying in/from solitude—is the subject of this article. Looking at new mortuary practices, new trends in both single and solitary lifestyles, and new initiatives in dealing with suicide, this article examines how the neoliberal shift to self-responsibility plays out in the everyday rhythms of being with/out others for postsocial Japanese. It also considers the implications of these shifts for the concept of the social itself.
in-Durable Sociality
Authors: Wool Zoë H.
Published: March 2017

This article considers the essential and unenduring attachments among grievously war-injured US soldiers remaking their lives at a military hospital. Their sense of being in common makes life bearable, but they do not constitute a community or even a cohort. Their profound attachments are especially brittle, breaking off cleanly as the contingencies of their unstable bodies intervene. Here, the enduring temporality of the social is secondary to practices of being between emergence and collapse. Addressing sociality here is not a romantic celebration of precarity or resilient intimacies. The article does not invest sociality and its residual social formations with lasting or redemptive force. Simply put, intimate and institutional attachments, both elected and involuntary, remain vital in the presence of pain even if they do not herald a hopeful futurity. In-durable sociality emerges as an ethics for now, situated in sociopolitical and material arrangement of the American afterwar that papers the present over with imagined futures: the individuating triumph of rehabilitation, the collectivizing identification with a war that could seem worth it, the stabilizing conjugation of we in a heteronational domestic life. The article traces injured soldiers’ experiences of being in common with others askance to this constellation of things to come, relating sociality to bare facts of perdurance.
Mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress
Authors: Piret Sian E. , Olinger Eric , Reed Anita A. C. , Nesbit M. Andrew , Hough Tertius A. , Bentley Liz , Devuyst Olivier , Cox Roger , Thakker Rajesh V.
Published: March 2017

Renal fibrosis is a common feature of renal failure resulting from multiple aetiologies, including diabetic nephropathy, hypertension and inherited renal disorders. However, the mechanisms of renal fibrosis are incompletely understood and we therefore explored these by establishing a mouse model for a renal tubular disorder, referred to as autosomal dominant tubulointerstitial kidney disease (ADTKD) due to missense uromodulin (UMOD) mutations (ADTKD-UMOD). ADTKD-UMOD, which is associated with retention of mutant uromodulin in the endoplasmic reticulum (ER) of renal thick ascending limb cells, is characterized by hyperuricemia, interstitial fibrosis, inflammation, and renal failure, and we used targeted homologous recombination to generate a knock-in mouse model with an ADTKD-causing missense cysteine to arginine uromodulin mutation (C125R). Heterozygous and homozygous mutant mice developed reduced uric acid excretion, renal fibrosis, immune cell infiltration and progressive renal failure, with decreased maturation and excretion of uromodulin, due to its retention in the ER. The ER stress marker, glucose regulated protein (GRP)78, was elevated in cells expressing mutant uromodulin in heterozygous and homozygous mutant mice, and this was accompanied by upregulation of two unfolded protein response pathways, both in vivo and ex vivo in primary thick ascending limb cells from homozygous mutant mice. However, this did not lead to an increase in apoptosis in vivo. Thus, we have developed a novel mouse model for renal fibrosis, which will be a valuable resource to decipher the mechanisms linking uromodulin mutations with ER stress and renal fibrosis.
The tubulin code at a glance
Authors: Gadadhar Sudarshan , Bodakuntla Satish , Natarajan Kathiresan , Janke Carsten
Published: March 2017

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the specialization of the microtubule cytoskeleton is the ‘tubulin code’, which is generated by (i) expression of different α- and β-tubulin isotypes, and by (ii) post-translational modifications of tubulin. In this Cell Science at a Glance article and the accompanying poster, we provide a comprehensive overview of the molecular components of the tubulin code, and discuss the mechanisms by which these components contribute to the generation of functionally specialized microtubules.
O novo Código de Processo Civil e sua aplicação no processo administrativo
Authors: Moreira Egon Bockmann
Published: March 2017

O Novo Código de Processo Civil brasileiro aplica-se imediatamente a todo os processos administrativos regidos por quaisquer outras leis. O que significa dizer que existe uma nova disciplina jurídica dos processos administrativos, a ser obrigatoriamente aplicada pelos órgãos e entidades da Administração Pública. The new Brazilian Civil Procedure Code applies immediately to all administrative process (even those ruled by other laws). Which is to say that there is a new legal discipline of all administrative processes, to be observed by government entities.
Corrupção, democracia e aparelhamento partidário do estado
Authors: Moreira Neto Diogo de Figueiredo
Published: March 2017

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The linguistic landscape of tourism: Multilingual signs in Lithuanian and Polish resorts
Authors: Ruzaitė Jūratė
Published: March 2017

The present study provides a snapshot of Polish and Lithuanian linguistic landscapes (LLs) in several resort cities situated in the border areas of the two countries. The data consists of 515 digital pictures of multilingual signs collected in the central and thus the most touristic parts of the cities. The main objectives in this research are to identify the authorship of multilingual signs, determine the types of establishments that employ multilingual signage, and analyse which languages coexist in popular tourist destinations. The interpretation of the results is grounded on the interrelation between multilingual signage, tourism as an important economic factor, and official language policies. The findings show that at least some major tendencies in language displays in LL do relate to tourist exchange and tourists’ needs. However, some trends (e.g. absence of Russian in Polish LLs) need to be analysed with regard to symbolic, economic, and ideological values attached to non-titular languages.Kokkuvõte. Jūratė Ruzaitė: Turismi keelemaastik: mitmekeelsed sildid Leedu ja Poola kuurortides. Artikkel käsitleb Poola ja Leedu piirialal paiknevate kuurortlinnade keelemaastikku. Artikli keeleainestikuks on 515 linnakeskustest ja seega turistidele enim huvi pakkuvatest linnaosadest kogutud mitme keelset silti. Uurimuse põhieesmärk on selgitada välja, kes on avalike siltide autorid ja mis asutused (ettevõtted, institutsioonid) neid kasutavad, ning analüüsida, millised keeled populaarsetes turismisihtkohtades kõrvuti eksisteerivad. Tulemuste tõlgendamisel toetub autor mitmekeelsete avalike siltide, turismi kui olulise majandusteguri ning ametlike keelepoliitikate vahelistele seostele. Tulemused näitavad, et vähemalt mõned suundumused avalike siltide keelevalikutes on seotud turismi ja turistide vajadustega. Seevastu mõnede teiste trendide analüüsimisel (nt vene keele puudumine Poola keelemaastikul) tuleb arvesse võtta muid mitteametlike keeltega seonduvaid sümboolseid, majanduslikke ja ideoloogilisi väärtusi.Märksõnad: keelemaastik; mitmekeelsed sildid; leedu keel; poola keel; turism; kuurordid; piiriala
Keelekasutuse aluspõhimõtted Eesti Vabariigi põhiseaduses ja nende rakendamine
Authors: Tomusk Ilmar
Published: March 2017

Artiklis vaadeldakse keelekasutust sätestavaid norme Eesti Vabariigi põhiseaduses, et välja selgitada, mil määral tagavad need eesti keele kasutamise kõigis olulisemates eluvaldkondades; kas need on piisavad eesti keele arendamiseks ja kaitsmiseks ning isikute keeleõiguste tagamiseks.Põhiseaduse keelesätete analüüs näitab, et keelekasutuse põhimõtted on põhiseaduses kirjas piisava selguse ning üksikasjalikkusega, võimaldades täita põhiseaduse preambulis seatud eesmärki tagada eesti rahvuse, keele ja kultuuri säilimine läbi aegade. Eesti keele kasutamine on tagatud põhiseaduslike institutsioonide tegevuses ning enamikus eluvaldkondades. Mõnes valdkonnas (kohalike omavalitsuste asjaajamine, haridus, meditsiin) jätab aga põhiseadusega antud eesti keele kasutamise võimaluste rakendamine soovida.Neid puudujääke on üritatud korvata riikliku keelejärelevalvega, kuid keelepoliitika heitlikkust, õigusaktides esinevaid puudujääke ja keeleoskuse probleemidest möödavaatamist ei ole võimalik järelevalvemeetmetega parandada. Põhiseadust aluseks võttes tuleks parandada seadusi ja rakendusakte.Abstract. Ilmar Tomusk: The constitution of the Republic of Estonia on the basic principles of language use, and their application. The article examines the rules of language use provided by the Constitution of the Republic of Estonia. The aim of the article is to find out to what extent the rules of language use ensure the use of the Estonian language in all key areas of life, whether they are sufficient for the development and protection of the Estonian language, and whether they guarantee the linguistic rights of individuals.The analysis of the language provisions of the Constitution shows that the key principles of language use are worded with sufficient clarity that they meet the objective set in the preamble of the Constitution to guarantee the preservation of the Estonian people, the Estonian language and the Estonian culture through the ages. The use of the Estonian language is guaranteed in constitutional institutions and also in most areas of life.In some areas (e.g. the administration of local governments, education and health care), however, the implementation of the main constitutional principles of language use on the legislative level is insufficient.Deficiencies in legislation have been compensated for by state language supervision. But the volatility of language policy, deficiencies in language policy planning and the ignoring of language proficiency problems cannot be compensated for by state language supervision. Language legislation should be aligned with the main constitutional principles of language use.Keywords: Constitution; official language; language of public administration; local government; education; health care; state language supervision
Birute Klaas-Langi bibliograafia 1981–2016
Authors: Praakli Kristiina , Niin Ülle
Published: March 2017

Birute Klaas-Langi bibliograafia 1981–2016
Management of patients with psoriasis
Authors: Croney Stacey
Published: March 2017

Stacey Croney, Clinical Nurse Lead Dermatology, Medway NHS Foundation Trust, Kent discusses the care of patients with psoriasis, including the latest drug treatments
Dermatology across healthcare settings
Authors: Bale Tracy
Published: March 2017

A day in the life of Tracy Bale, Senior Nurse Dermatology, Rheumatology and Radiology, and Dermatology Clinical Nurse Specialist, Aneurin Bevan University Health Board, South Wales, who was awarded third place at the BJN Awards 2016 for Dermatology Nurse of the Year
The origins of a two-tier profession: a nursing school at a Poor Law infirmary
Authors: McCrae Niall , Kuzminska Katerina
Published: March 2017

Niall McCrae, Lecturer, and Katerina Kuzminska, Postgraduate Nursing Student, Florence Nightingale Faculty of Nursing and Midwifery, King's College, London, chart the influences of Nightingale's Poor Law infirmary reforms
Student nurses' perceptions of dignity in the care of older people
Authors: Macaden Leah , Kyle Richard G , Medford Wayne , Blundell Julie , Munoz Sarah-Anne , Webster Elaine
Published: March 2017

Aim:

The aim of this research was to investigate student nurses' perceptions of the concept of dignity in the care of older people. Student nurses regularly move between the classroom and the clinical setting and are thus ideally placed to cast light on the barriers that exist to providing dignity in care and the way in which their theoretical understanding of dignity is shaped by exposure to the practice setting.

Method:

All student nurses on a three-year undergraduate nursing programme at one university were invited to participate in an online questionnaire survey and focus groups.

Results:

Students equated the practice of upholding dignity with listening to individuals, involving them in decision making and maintaining their privacy. Participants were mostly confident about what dignity meant in practice, but were unsure about the more theoretical aspects. Four major barriers to the promotion of dignity were highlighted—these were organisational, environmental, professional and personal in nature.

Conclusion:

Dignity education should occupy a more prominent position in pre-registration nursing programmes.
Haemodialysis, nutritional disorders and hypoglycaemia in critical care
Authors: Crespo Jeiel Carlos Lamonica , Gomes Vanessa Rossato , Barbosa Ricardo Luís , Padilha Katia Grillo , Secoli Silvia Regina
Published: March 2017

This study aimed to determine hypoglycemia incidence and associated factors in critically ill patients. It looked at a retrospective cohort with 106 critically ill adult patients with 48 hours of glycaemic control and 72 hours of follow up. The dependent variable, hypoglycaemia (≤70 mg/dl), was assessed with respect to independent variables: age, diet, insulin, catecholamines, haemodialysis, nursing workload and the Simplified Acute Physiology Score. Statistical analysis was performed using Student's t-test, Fisher's exact test and logistic regression at 5% significance level. Incidence of hypoglycaemia was 14.2%. Hypoglycaemia was higher in the group of patients on catecholamines (p=0.040), with higher glycaemic variability (p<0.001) and death in the intensive care unit (p=0.008). Risk factors were identified as absence of oral diet (OR 5.11; 95% CI 1.04–25.10) and haemodialysis (OR 4.28; 95% CI 1.16–15.76). Patients on haemodialysis and with no oral diet should have their glycaemic control intensified in order to prevent and/or manage hypoglycaemic episodes.
End-of-life care guidelines and care plans in the intensive care unit
Authors: Luckett Alison
Published: March 2017

The aim of this literature review was to examine end-of-life (EoL) care practice in the intensive care unit (ICU). By exploring the literature, it is hoped to suggest how national guidance can be integrated into the ICU setting. Delivering high-quality, patient-centred EoL care is high priority on the UK health agenda. The highly technological environment within the ICU can create barriers to recognising death and initiating EoL care planning. Despite recommendations in the literature for the integration of standardised guidance, implementation, compliance and evaluation are yet to be widely reported. This literature review highlights the need for ICU health professionals to embrace EoL guideline recommendations. Development of robust processes is vital to inform future practice.
The high cost of clinical negligence litigation in the NHS
Authors: Tingle John
Published: March 2017

John Tingle, Reader in Health Law at Nottingham Trent University, discusses a consultation document from the Department of Health on introducing fixed recoverable costs in lower-value clinical negligence claims
Returning to the gym with a stoma: a patient's perspective
Authors: Wright Zoey
Published: March 2017

Zoey Wright shares her experiences of adjusting to life with a stoma and how she overcame the practical and psychological challenges it posed
Stoma-associated problems: the important role of the specialist nurse
Authors: McGrath Anthony
Published: March 2017

Following on from a study carried out with his colleagues in 2010, Anthony McGrath, Head of Department Adult Nursing and Midwifery, London South Bank University, considers the ongoing problems faced by patients with stomas and the importance of support from stoma care nurses
Reducing the incidence of parastomal hernia with a simple surgical technique
Authors: Hayles Kevin , Almoudaris Alex
Published: March 2017

The incidence of parastomal hernia is reported at between 10% and 50%. The development of a hernia after stoma surgery can lead to both physical and psychological problems and may reduce the individual's quality of life. Many garments and appliances are aimed at managing a stoma and a peri-stomal hernia. From a surgical perspective, to date there has been no real success in achieving a reduction in parastomal hernia incidence. The cost of managing a parastomal hernia is reported as being in excess of £1 million a year in England for non-surgical management alone. Surgical repair of parastomal hernia carries not only a financial burden but an increased risk of mortality and morbidity.
Local governance under austerity: hybrid organisations and hybrid officers
Authors: Pill Madeleine , Guarneros-Meza Valeria
Published: March 2017

Using the case of Cardiff, Wales, we argue that the hybridisation of local governance forms is exacerbated by the downscaling and offloading of austerity politics. Conceptualising hybridity as a process which operates across governmental scales, at the organisational and at the individual level helps understand the growing complexities of local governance under austerity and the tensions which arise in seeking to assemble locally appropriate ideas and practices. Conceptualising hybridity as practice, we consider how ‘hybrid officers’ at the frontline experience austerity, their situated agency, and the implications for higher levels of governance.
Citizen participation and changing governance: cases of devolution in England
Authors: Prosser Brenton , Renwick Alan , Giovannini Arianna , Sandford Mark , Flinders Matthew , Jennings Will , Smith Graham , Spada Paolo , Stoker Gerry , Ghose Katie
Published: March 2017

The current process of devolving powers within England constitutes a significant change of governance arrangements. This process of devolution has been widely criticised for including insufficient consultation. This paper assesses whether that criticism is fair. Modifying Archon Fung’s framework for the analysis of public participation mechanisms, we begin by considering whether the depth of public engagement has been limited. Then, by comparing these consultation practices with other examples (including one we have ourselves trialled in pilot experiments), we find that deeper forms of public engagement would have been both possible (though at some financial cost) and productive.
Building capacity for evidence-informed decision making: an example from South Africa
Authors: Stewart Ruth , Langer Laurenz , Wildeman Russell , Erasmus Yvonne , Maluwa Louis Gerald , Jordaan Sunet , Lötter Desyreé , Mitchell Janine , Motha Precious
Published: March 2017

To maximise the potential impact and acceptability of EIDM capacity building, there is a need for programmes to coordinate their remits within existing systems, playing both ‘insider’ and ‘outsider’ roles. Through a review of the South African evidence-policy landscape and analysis of a stakeholder event that brought together EIDM role players, this paper illustrates how one capacity-building programme navigated its position within the national evidence-policy interface. It identifies strategies for improving the acceptability and potential effectiveness of donor-funded EIDM capacity-building activities: understanding the evidence-policy interface, incorporating programmes into the decision-making infrastructure (being an ‘insider’), whilst retaining an element of neutrality (being an ‘outsider’).
The Phone Booth Project. Martu Media Memories: A Conversation in Three Parts
Authors: Biddle Jennifer Loureide , Taylor Curtis , Hibberd Lily
Published: March 2017

This paper is a three-way conversation between anthropologist Jennifer Biddle and the artists/collaborators of the intercultural new media installation The Phone Booth Project (2012), Curtis Taylor and Lily Hibberd. The discussion considers the importance of this collaborative, community-based, art work in terms of its capacity to reveal Martu Indigenous media history and counter-memory in the greater contemporary context of a national ‘digital divide’.
Re:lating Necessity and Invention: How Sara Diamond and The Banff Centre Aided Indigenous New Media Production (1992–2005)
Authors: L’Hirondelle Cheryl
Published: March 2017

For many years The Banff Centre was known to be instrumental in supporting the creation of many Indigenous curatorial, visual art and media art initiatives from the early 90s. This interview with Dr. Sara Diamond sheds insight and make links to her background with the B.C. labour movement, her early practice as a social activist and video maker, her close friendships with several noted key Indigenous artist frontrunners and the lead she then took to continually include and expand the presence of Indigenous artists and thinkers, our worldviews and communities at The Banff Centre from 1992 to 2005.
LEFT_CHANNEL
Authors: Inutiq Geronimo
Published: March 2017

LEFT_CHANNEL is a compilation of experiments of digital image manipulation of archival film sourced from the Prelinger Archives and the NFB. Some of the footage was obtained with the collaboration of Wapikoni Mobile during the 400th anniversary of Quebec. This video was shown as part of a multi-channel installation in the ARCTIC NOISE project as well as the ISUMAGINAGU exhibit during the Asinabka Festival.
Trans sites of self-exploration: From print autobiographies to blogs
Authors: Lodge Reid
Published: March 2017

As trans people become more visible, form stronger communities, and continue to find new platforms to tell trans stories, our conversations surrounding sex and gender expand, become more nuanced, and we are able to articulate new ways of understanding and embodying gender. This article begins with a discussion of three autobiographical texts by trans-identified men: Jamison Green’s Becoming a Visible Man (2004), Matt Kailey’s Just Add Hormones (2005) and Max Wolf Valerio’s The Testosterone Files (2006). I argue that these texts all belong to a ‘second wave’ of trans activism and advocacy that was emerging in the 1970s and 1980s, around the time that the authors began socially and physically transitioning. This ‘second wave’ of trans activists moved away from dominant heteronormative narratives of trans identity of the ‘first wave’ that relied on respectability politics, but continued to build on the idea of a clear, cohesive and enduring sense of gender identity. I then move on to interrogate the idea of a ‘third wave’ of trans discourse through an analysis of two blogs maintained on Tumblr.com by authors who originally identified as binary trans men, but whose experiences with moments of ‘unintelligibility’ in social and discursive contexts lead them to question the idea of a clear, cohesive and enduring sense of gender identity.
Retinol binding protein 4, obesity, and insulin resistance in adolescents
Authors: Noor Ronaldi , Rini Eka Agustria , Yerizel Eti
Published: March 2017

Background Obesity is a global problem. Even in poor and developing countries, obesity has reached alarming levels. In childhood, obesity may lead to insulin resistance. Retinol binding protein (RBP4), secreted primarily by liver and adipose tissues, was recently proposed as a link between obesity and insulin resistance. The role of RBP4 in pediatric obesity and its relationship with insulin resistance have not been well elucidated.Objective To compare RBP4 levels in obese and lean adolescents and to assess for a relationship between RBP4 levels and insulin resistance. Method This cross-sectional study was conducted in three senior high schools in Padang, West Sumatera, Indonesia. Subjects were adolescents aged 14-18 years, who were obese or normal weight (n=56). We measured subjects’ body mass index (BMI) and serum RBP4 concentrations. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR) index.Results Similar RBP4 levels were found in the obese and normoweight groups (P>0.05). Higher RBP4 levels were found in the insulin resistant compared to the non-insulin resistant group, but the difference was not significant (P > 0.05).Conclusion There is no significant difference in mean RBP4 levels in obese adolescents compared to normoweight adolescents. Nor are mean RBP4 levels significantly different between obese adolescents with and without insulin resistance.
Lactate profiles of pediatric shock patients in Cipto Mangunkusumo General Hospital 2015: a pilot study
Authors: Yuniar Irene
Published: March 2017

Background The 2015 Surviving Sepsis Campaign (SSC) guidelines for management of shock recommend blood lactate to assess the success of resuscitation in shock. However, a study in adults found that 1/3 of septic shock patients had normal lactate levels (alactatemia) and lower mortality rates.Objective To evaluate lactate profiles, possible factors affecting lactate levels, and mortality outcomes in pediatric shock patients in the emergency room (ER) and pediatric intensive care unit (PICU).Methods This was a retrospective study on pediatric shock patients aged 1 month to 18 years in the ER or PICU  from June 2014 to December 2015. Data were taken from subjects’ medical records including lactate levels, examination data required to calculate a PELOD score, and mortality outcomes.Results Of 223 shock patients evaluated, only 92 cases (41.2%) underwent lactate examinations. Of these, 59 (64.1%) had alactatemia and 33 (35.9%) had hyperlactatemia. A total of 23.7% of the alactatemia group and 36.4% of the hyperlactatemia group died, thus, the initial lactate level was not significantly associated with patient outcomes (P=0.197). The mortality rates of patients with <10% and ³10% lactate clearance were 31.3% and 17.6%, respectively (P=0.362).Conclusion In alactatemia patients, lactate level can not be used as a goal for resuscitation. Further study is needed to find a biomarker for assessing the success of pediatric shock resuscitation. Moreover, the clinical relevance of alactatemia is uncertain in pediatric shock patients.
Germinação e desenvolvimento in vitro de orquídea epífita do Cerrado
Authors: Sousa Kellen Cristhina Inácio , Silva Carlos Sousa , Silva Daniela Mota , Sibov Sérgio Tadeu , Araújo Leila Garcês , Faria Paulo Roberto
Published: March 2017

Orchids are very popular plants due to the beauty and diversity, of colors and shapes, of their flowers. In order to obtain uniformity, vigor and sanity of the seedlings as well as to produce large quantities for the commercialization is used the in vitro propagation. The objective of this study was to evaluate the germination and in vitro development of Cyrtopodium saintlegerianum for acclimatization. The MS, MS½, Knudson C modified and Simplified media were tested on seed germination. In the development of the seedlings were evaluated Knudson C modified, MS and MS modified (addition of auxin and cytokinin). The MS, MS½ and Knudson C modified media promoted germination above 80% after seven days. However, in the Simplified medium the seeds germinate after thirty days. In the two evaluations, thirty and sixty days after the beginning of the experiment, the Knudson C modified medium was efficient for the observed variables demonstrating their potential use in germination and development of this species.
Oral focal mucinosis of gingiva - a rare case report and review of literature
Authors: Dabbiru Chandini , Mahadev Naik Raghavendra , Moturi Kishore , Rajkumar Govind
Published: March 2017

Oral focal mucinosis (OFM) is a rare soft-tissue lesion of unknown etiology. Clinically it appears as asymptomatic round lesions and histologically, characterized by focal myxoid degeneration of connective tissue with presence of stellate shaped fibroblasts which were also evident in the present case. This case report stresses on the fact that diagnosis of OFM is almost impossible hence diagnosis should be confirmed by histopathological examination following incisional or excisional biopsy. Through this article we present a rare case of one such lesion on the gingiva and enumerate the most characteristic and myxomatous lesions. Thus though rare, OFM must be considered in the differential diagnosis of soft tissue overgrowths in oral cavity. Here, we describe the clinical and histopathologicalÂ Â  presentation and subsequent management of OFM in a female patient.
Umwelt- und Klimaforschung an der Universität Graz
Authors: Lackner Bettina C. , Steininger Karl W.
Published: March 2017

Zu den großen Herausforderungen des 21. Jahrhunderts gehören der Klimawandel und der globale Wandel. Die Umwelt- und Klimaforschung ist an der Universität Graz in einer für diesen Bereich notwendigen Breite abgedeckt. Die Disziplinen befruchten einander gegenseitig
in ihrer internationalen Sichtbarkeit. Dazu trägt auch das jüngst eingerichtete Doktoratskolleg Klimawandel bei.
Transdisziplinäre Forschung in Reallaboren: Ein Plädoyer für Einheit in der Vielfalt
Authors: Ukowitz Martina
Published: March 2017

Reaktion auf T. Jahn, F. Keil in GAIA 25/4 (2016): Reallabore im Kontext transdisziplinärer Forschung
Research on Natural Resources: The Quest for Integration Revisited
Authors: Bornemann Basil , Bernasconi Andreas , Ejderyan Olivier , Schmid Franziska , Wäger Patrick , Zingerli Claudia
Published: March 2017

The dysfunctional use of resources in modern societies arises from increasingly fragmented ways of understanding natural resources. Consequently, there have been repeated calls for integrative knowledge production, and various approaches to integration have been proposed, including
such as interdisciplinary or transdisciplinary resource research and integrated resource management. The conceptual space proposed here can be applied as a tool for imagining and designing new approaches, methods, and research techniques toward a more reflexive understanding of integration-oriented
research on natural resources.
Reviewing the relation between the problem solving skills of school of health students and their social skill levels
Authors: Ergün Gül , Şimşek Arslan Buket
Published: March 2017

This research aims at reviewing the relation between the problem solving skills of health high school students and their social skill levels.  It was planned to be descriptive. The universe of the research was composed of nursing students in the health high school. The sample was determined to be the whole of the universe. A written permission was taken from the management of the health high school regarding the research. Problem Solving Inventory and Social Skill Inventory; the form towards socio-demographic data prepared by the researchers was used. SPSS-16 software programme were used to analyze the data. The participants were a total of 248 people, with %76.2 female. 66 of the students are from the 1st grade, 67 from the 2nd, 58 from the 3rd and 57 from the 4th grade. When some substance use properties of the students were observed, %11.3 stated they smoke, %9.3 of the students stated that they drink alcohol. Statistically significant relations were determined between problem solving and sub-scales regarding social skills. A statistically significant relationship was identified between confidence in the problem solving skills and emotional expressivity. According to this, as the score average for confidence in problem solving skills increase, emotional expressivity decreases. That is, the non-verbal communication skills of the individual are decreasing. Consequently, as the problem solving skills of nursing students decrease, their social skill levels are decreasing as well.
CORPORATE SOCIAL RESPONSIBILITY (CSR) DALAM PERSPEKTIF PEMBANGUNAN BERKELANJUTAN
Authors: Sunaryo Sunaryo
Published: March 2017

The mandatory Corporate Social Responsibility (CSR) which has regulated under the law requires company to have CSR programs which oriented to sustainable development. The obligation to implement the CSR has arranged in a variety of laws and regulations, both in the  Constitution and in other sectoral legislation, such as about the company and the environment. Therefore, companies that want to corporate sustainability, in making CSR programs in addition have to pay attention to the socioeconomi aspects, should also pay attention to environmental aspects. In otherwords, CSR programs need to be aligned with the  of  development as mandated bythe Constitution.Diwajibkannya Corporate Social Responsibility (CSR oleh undang-undang, menuntut perusahaan untuk memiliki program-program CSR yang berorientasi pada pembangunan berkelanjutan. Kewajiban melaksanakan CSR tersebut diatur dalam berbagai peraturan perundangan, baik dalam UUD 1945 maupun dalam undang-undang sektoral lainnya, seperti tentang perusahaan maupun tentang lingkungan. Oleh karena itu, perusahaan yang ingin mencapai usahanya berkelanjutan, maka di dalammembuat program CSR di samping harus memperhatikan aspek sosial ekonomi, juga harus memperhatikan aspek lingkungan. Dengan kata lain, program-program CSR perlu diselaraskan dengan prinsip-prinsip pembangunan berkelanjutan sebagaimana yang diamanatkan dalam UUD 1945.
SANDERA PAJAK SEBAGAI ALAT PAKSA DALAM PENAGIHAN UTANG PAJAK ( Studi tentang Penegakan Hukum Pajak Melalui Sandera Pajak )
Authors: Ispriyarso Budi
Published: March 2017

Problems found in this study is the reason why the government uses tax hostages in tax collection, how hostage force to used as a tool in the collection of tax debts and how the hostage-taking in terms ofjuridical aspect. The approach method used in this research is the Socio Legal Research. Result is that there are several factors that become a reason for the tax hostage. Government (fiscus) in collecting tax debts with the tax hostages have been carried out in accordance with the provisions of the act . According to aspects of legal certainty, tax hostages in Indonesia has had a legal protection, named Law No. 19 of 2000 as well as some regulatory other aspects . From the legal justice aspect, protection law also granted to taxpayers affected by the gijzeling. From the aspect of expediency, the application of the gijzeling prove to be useful in improving taxpayer compliance.Permasalahan yang terdapat dalam penelitian ini adalah mengapa pemerintah menggunakan sandera pajak  dalam penagihan pajak, bagaimana penyanderaan dipergunakan sebagai alat paksa dalampenagihan utang pajak dan bagaimana penyanderaan ditinjau dari aspek yuridis. Metode Pendekatan yang dipergunakan dalam penelitian ini adalah metode Socio legal Research. Hasil Penelitian adalah ada beberapa faktor yang menjadi alasan dilakukannya penyanderaan pajak. Pemerintah (fiscus) dalam melakukan penagihan utang pajak dengan sandera pajak telah dilakukan sesuai dengan ketentuan undang-undang.Berdasarkan aspek kepastian hukum, sandera pajak di Indonesia telah mempunyai payung hukumnya  yaitu UU Nomor 19 tahun 2000 serta beberapa peraturan lainnya. Dari aspek keadilan, perlindungan hukum juga diberikan kepada wajib pajak yang terkena sandera pajak.Dari aspek kemanfaatan, penerapan sandera pajak bermanfaat dalam peningkatan kepatuhan wajib pajak.
ILMU HUKUM NASIONAL DALAM MENUNJANG PEREKONOMIAN INDONESIA BERASASKAN KEADILAN SOSIAL
Authors: Rahayu Derita Prapti
Published: March 2017

Science including legal study that is not accompanied by knowledge of the Godhead ( the Pancasila ) is incomplete . Legal science coupled with the values   of Pancasila , gave birth to legal experts who will make the rule of law in our country can not be separated from the Pancasila as the state . Containsbasic values   of local wisdom keindonesiaan that principles are translated into the fifth principle. Ultimately creating a socially just economy called Pancasila economy .Ilmu pengetahuan termasuk ilmu hukum yang tidak dibarengi dengan ilmu Ketuhanan (dalam Pancasila) adalah tidak lengkap. Ilmu hukum yang dibarengi dengan nilai Pancasila, melahirkan para pakar hukum yang akan membuat aturan hukum di Negara kita tidak terlepas dari Pancasilasebagai dasar negara. Mengandung nilai-nilai dasar dari kearifan lokal keIndonesiaan yang dijabarkan ke dalam kelima silanya. Pada akhirnya menciptakan perekonomian berkeadilan sosial yang disebut dengan ekonomi Pancasila.
KEWENANGAN PEMERINTAH DAERAH NUSA TENGGARA TIMUR DALAM RANGKA OPTIMALISASI PENGELOLAAN ASET TANAH
Authors: Djafar Fadly Afand
Published: March 2017

This research aims to study the regional authority of East Nusa Tenggara Province in land assets management. The method research uses normative juridical, with the prescriptive approach. The research results conclude that the regional authority of East Nusa Tenggara Province in land assets is based on The Government Regulation No.6/2006 No.38/2008 jo No.27/2014 about The Management of State Property/Region;The Regulation of Minister of Home Affairs No.17/2007 about Technical Guidelines for Management of Regional Property and The Regional Regulation No.3/2008 about The Management of Regional Property. The management of land asset can be optimized through land rental.Penelitian ini bertujuan untuk mengkaji kewenangan daerah khususnya di Provinsi Nusa Tenggara Timur dalam pengelolaan aset daerah berupa aset tanah. Metode yang digunakan dalam penelitian ini yuridis normatif dengan pendekatan preskriptif. Hasil penelitian menyimpulkan bahwa kewenangan daerah Provinsi Nusa Tenggara Timur harus sesuai dengan PP No.6/2006 jo PP No.38/2008 jo PP No.27/2014 tentang Pengelolaan Barang Milik Negara/Daerah; Permendagri No.17/2007 tentang Pedoman Teknis Pengelolaan Barang Milik Daerah serta Perda No.3/2008 tentang Pengelolaan Barang Milik Daerah. Optimalisasi pengelolaan aset tanah dapat dilakukan melalui sewa
HAK MENGUASAI NEGARA DALAM PENGELOLAAN SUMBER DAYA AIR SEBAGAI PERWUJUDAN DOKTRIN NEGARA HUKUM KESEJAHTERAAN
Authors: Rachmi Handayani I Gusti Ayu Ketut
Published: March 2017

Constitutional Court Decision No. 85 / PUU - XII / 2014 to restore control over the water resources of the country, including in terms of management and enterprise. This study discusses how the construction of the state's right to control the management of the water resources of our doctrines of the welfare state. Methods used juridical empirical. This research resulted in the construction of the state's right to control the management of the water resources of our doctrines of the welfare state that is the heart of the Law on Water ResourcesPutusan Mahkamah Konstitusi RI Nomor 85/PUU-XII/2014 mengembalikan penguasaan atas sumber daya air kepada negara termasuk dalam hal pengelolaan dan pengusahaannya. Penelitian ini membahas bagaimana konstruksi hak menguasai negara dalam pengelolaan sumber daya air sebagai perwujudan doktrin negara kesejahteraan. Metode Penelitian yang digunakan adalah yuridis empiris. Penelitian ini menghasilkan konstruksi hak menguasai negara dalam pengelolaan sumber daya air sebagai perwujudan doktrin negara kesejahteraan yang merupakan jantung Undang-Undang tentang Sumber Daya Air
IMPLEMENTASI KEADILAN RESTORATIF DAN PLURALISME HUKUM DALAM SISTEM PERADILAN PIDANA ANAK DI INDONESIA
Authors: Rochaeti Nur
Published: March 2017

Children in the justice system requires different handling with adults, because children are vulnerable to violence, abuse and exploitation. BAPAS role along Institutes Companion Pusaka Indonesian, Medan City Government has involved community participation in the implementation of Diversion and restorative justice in the juvenile  criminal justice system as an effort to give children the best interests of the childAnak-anak dalam sistem peradilan membutuhkan penanganan yang berbeda dengan orang dewasa, karena anak-anak rentan mengalami kekerasan, perlakuan salah dan eksploitasi.  Peran BAPAS bersama Lembaga Pembaga Pendamping Pusaka Indonesia, Pemerintah Daerah Kota Medan telah melibatkan partisipasi masyarakat dalam implementasi Diversi maupun keadilan restoratif dalam sistem peradilan pidana anak sebagai upaya memberikan kepentingan terbaik bagi anak
TANGGUNG JAWAB NEGARA UNTUK MENERIMA BANTUAN KEMANUSIAAN SAAT TANGGAP DARURAT BENCANA ALAM
Authors: Puspita Natalia Yeti
Published: March 2017

Every year international community is faced with the challenge of responding to disaster that exceeds the capacity of the existing national infrastructure.The state is the principal actor that has sovereignty to cope with natural disasters in the country. The principle of sovereignty should be interpreted broadly as a responsibility to protect are included in this receiving outside assistance when natural disasters occur massively and infrastructure of the country concerned is not able to copeSetiap tahun masyarakat internasional dihadapkan pada tantangan meresponbencana alam yang melebihi kapasitas infrastruktur nasional yang ada. Negara merupakan aktor utama yang mempunyai kedaulatan untuk menanggulangi bencana alam yang terjadi di negaranya tersebut. Prinsip kedaulatan tersebut harus diartikan secara luas sebagai sebuah tanggung jawab untuk melindungi termasuk dalam hal ini menerima bantuan dari pihak luar manakala bencana alam tersebut terjadi secara massif dan infrastruktur negara yang bersangkutan tidak mampu menanggulanginya
DEKONSTRUKSI STELSEL ABSORPSI DALAM PERBARENGAN TINDAK PIDANA SEBAGAI UPAYA MEWUJUDKAN KEADILAN SUBSTANTIF
Authors: Tongat Tongat
Published: March 2017

This study aims to address the central issue of the public emergence of alleged lack of consistency in imposing criminal judge in the case perbarengan crime. The method used is normative research. Construction of the existing criminal stelsel in perbarengan criminal offense not to give clarity to the judge in a convict. So too there is no minimum threshold should be clear criminal judge imposed, thereby potentially causing injustice, especially when compared to criminal punishment in the case of a single criminal actPenelitian ini bertujuan untuk menjawab isu sentral munculnya dugaan publik atas tidak adanya konsistensi hakim dalam menjatuhkan pidana dalam hal terjadi perbarengan tindak pidana. Metode penelitian yang digunakan adalah penelitian normatif. Konstruksi existing tentang stelsel pidana dalam perbarengan tindak pidana tidak memberi kejelasan kepada hakim dalam menjatuhkan pidana. Demikianpun tidak ada batas minimum pidana yang jelas yang harus dijatuhkan hakim, sehingga berpotensi menimbulkan ketidakadilan khususnya jika dibandingkan dengan penjatuhan pidana pada kasus tindak pidana tunggal
KEWENANGAN KONSTITUSIONAL PRESIDEN TERHADAP “HAL IHWAL KEGENTINGAN YANG MEMAKSA”
Authors: Marwiyah Siti
Published: March 2017

The Constitutional of the Republic of Indonesia (UUD NRI 1945) gives nit a little authorizes to the President. One of the authority is to set “happenings crunch yhat fonced” because the country is not always in a state of normal//peace/stable. At the time of the reverse of President as head of state was given the constitutional authorithy to establish a state of emergency in the form of Government Regulation in Leu of Law (PERPPU)