bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of clinical manifestations, diagnostics and treatment of oral mucosa multi-formed exudative erythema
Authors: Lavrovskaya Ya. A. , Romanenko I. G. , Lavrovskaya O. M. , Postnikova O. N. , Logadyr T. A.
Published: April 2021

The article discusses etiological factors, pathogenesis, features of clinical manifestations, optimization of diagnosis, treatment and prevention of exudative erythema multiforme of the oral cavity. Currently, such pathological changes in the oral cavity are insufficiently studied and remain relevant in modern dentistry. Promising approaches to the successful treatment of this disease involve the implementation of additional examination and joint treatment with related specialists. Numerous studies of domestic and foreign authors demonstrate that special attention is paid to the prevention of re-morbidity of exudative erythema multiforme, aimed at preventing the occurrence of lesions of the oral mucosa.
Placenta Accreta Overlying a Caesarean Section Scar: A 10-Year Experience in a Tertiary-Care Centre in Portugal
Authors: Cal Margarida , Nunes Carla , Clode Nuno , Ayres-de-Campos Diogo
Published: April 2021

Introduction: Placenta accreta spectrum disorders are among the leading causes of maternal morbidity and mortality and their prevalence is likely to increase in the future. The risk of placenta accreta spectrum disorders is highest in cases of placenta previa overlying a previous cesarean section scar. Few studies have evaluated placenta accreta spectrum disorders in Portugal. The aim of this study was to review the cases of placenta accreta spectrum overlying a cesarean section scar managed in a Portuguese tertiary center over the last decade.Material and Methods: Retrospective, cross-sectional study, with data collected from hospital databases. Only cases with histopathological confirmation of placenta accreta spectrum were included.Results: During the study period, 15 cases of placenta accreta spectrum overlying a cesarean section scar were diagnosed (prevalence 0.6/1000). All cases were diagnosed antenatally. A transverse cesarean section was present in all cases; 13 were managed by a scheduled multidisciplinary approach, while two required emergent management. Total or subtotal hysterectomy was performed in 12 cases. There were no cases of maternal or neonatal death. Histopathological evaluation confirmed nine cases of placenta accreta, three cases of placenta increta and three cases of placenta percreta.Discussion: Early antenatal diagnosis is important for a programmed multidisciplinary management of these cases, which may reduce potential morbidity and mortality and ensure better obstetric outcomes.Conclusion: This case series of placenta accreta spectrum overlying a cesarean section scar reports the reality of a tertiary-care perinatal center in Portugal, in which no maternal or neonatal mortality due to placenta accreta spectrum was registered over the last decade; this may be attributed to prenatal diagnosis and a coordinated multidisciplinary team approach.
Impacto do Confinamento em Crianças e Adolescentes
Authors: Pedro dos Reis Filipa , Amaro Rita , Martins Silva Filipa , Vaz Pinto Sofia , Barroca Inês , Sá Teresa , Ferreira Carvalho Rui , Cartaxo Teresa , Boavida José
Published: April 2021

N/a.
CXCL13 CSF level inversely correlates with duration of disease in primary progressive multiple sclerosis
Authors: Losy Jacek , Iwanowski Piotr , Kaufman Elżbieta , Wójcicka Marlena
Published: April 2021

Chemokines are important factors in the immunopathogenesis of multiple sclerosis. The objective of the study was to examine the CSF and serum levels of CXCL13 and CCL5 chemokines in primary progressive MS, compare results with relapsing remitting MS and control group with other noninflammatory neurological disorders. The levels of chemokines was measured by ELISA method. The CXCL13 CSF levels in PP and RR MS were higher in comparison with control group, without significant differences between these podgroups. Additionally CXCL13 level in PP MS inversely correlated with duration of the disease. CCL5 CSF level was also significantly higher in PP MS in comparison with control group. The results demonstrate involvement of CXCL13 and CCL5 chemokines in the immunopathogenetic mechanisms of primary progressive MS.
Ischemia-modified albumin in migraine patients during interictal period
Authors: Michalak Slawomir , Osztynowicz Krystyna , Płóciniczak Alicja , Myszka Waldemar , Nowicki Marcin , Węgrzyn Danuta , Drzewiecka Małgorzata , Kapecka Kinga , Kozubski Wojciech
Published: April 2021

Aim. Ischemia-modified albumin (IMA) is a marker of myocardial ischemia and may be affected by ischemia occurring in other tissues. Migraine has been reported as a risk factor of ischemic stroke or cardiovascular events. Dysfunction of endothelial cells, as well as association with arteriopathies was evidenced in migraine patients. The aim of this study was to evaluate interictal IMA in migraine patients.Material and Methods. Fifty migraineurs aged 38 ± 9 years were included in the study. The control group consisted of 25 healthy volunteers aged 37 ± 8 years. In all subjects neurological examination was carried on, as well as clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS. Ischemia-modified albumin was evaluated by means of spectrophotometric method with the use of cobalt chloride. The concentrations of total cholesterol, HDL- and LDL-cholesterol, triglycerides, homocysteine, C-reactive protein and Lp(a) were analyzed with routine spectrophotometric methods.Results. IMA was significantly (P = 0.0108) higher in migraine patients (0.101; 0.00–0.327 O.D.) than in controls (0.00; 0.00–0.102 O.D.; median; interquartile range). Migraineurs with aura have also higher IMA than controls. IMA correlated (rS = 0.383, P = 0.0073) with VAS and with homocysteine concentration (rS = 0.430, P = 0.0026). Multiple regression analysis of IMA and atherosclerosis risk factors showed significant correlation (P = 0.0247) with HDL cholesterol (R = 0.2958) and triglycerides concentrations (R = 0.3285).Conclusions. IMA formation in migraine patients, as a marker of oxidative stress even during interictal period in patients with hyperhomocysteinemia and/or hypertriacylglyceridemia can reflect a milieu of factors which further increases the risk for cardiovascular complications.
Increased neopterin concentration in patients with primary arterial hypertension
Authors: Cieślewicz Artur , Korzeniowska Katarzyna , Bogdański Paweł , Jabłecka Anna
Published: April 2021

The data on the safety profile of anti-tumor necrosis factor (anti-TNF) therapy in real-life patients cohorts with in flammatory bowel disease (IBD) still are lacking. Neopterin is a pteridine derivative produced from guanosine triphosphate mainly by activated monocytes and macrophages in response to cytokines produced by T-lymphocytes and natural killer cells. Changes in neopterin level reflect the stage of activation of cellular immune system and can be associated with various diseases. Low-grade inflammation is also an important factor in the pathophysiology of hypertension. In presented study we assessed neopterin concentration in 63 patients with primary arterial hypertension compared to 14 control healthy volunteers. Obtained results confirmed increased neopterin level in patients group.
A 10 year data analysis of lymphatic system metastasis and recurrence in individuals affected by malignant tumors within the oral cavity and maxillofacial region
Authors: Dreksler Adam , Lenkowski Marcin , Marcinkowski Michał , Nowaczyk Marian Tomasz , Osmola Krzysztof , Pełczyński Tomasz , Radzewicz Gleb , Rahma Samir
Published: April 2021

Introduction. Tumors are only second to cardiovascular diseases as a cause of death. According to World Health Organization (WHO), these statistics will increase especially within aging and well-developed countries.Aim. The aim of the research was to analyze the frequency of recurrences and lymph node involvement in individuals affected by malignant tumor of head and neck region. Special attention was paid to tumor location, sex, age of the affected individuals as well as histological appearance of the tumor.Material and methods. The research team has analyzed medical data record base from 2002–2011 and selected a group of 1697 individuals treated for malignant tumors within the oral cavity and maxillofacial region.Results. Reoperation was carried out on 192 patients due to recurrences and lymph node involvement; (11.3%) of the study group. Patients were further subdivided into groups according to sex, age, histological appearance and anatomical location of tumor recurrence. Results were compared with the available literature.Conclusions. Our data confirms the findings of other research groups in terms of accuracy of early diagnostic screening and its effect on final tumor treatment. It is also essential to accentuate the importance of post-treatment monitoring within first five years after initiation of treatment, which allows for an early determination of local recurrences and/or lymph node involvement.
Early differentation of lamellar structure of the intervertebral disc in staged human embryos
Authors: Woźniak Witold , Grzymisławska Małgorzata , Łupicka Joanna , Bruska Małgorzata , Piotrowski Adam , Gałązka Anna , Rojewska Magdalena , Sobański Jarosław
Published: April 2021

Introduction. In the vast literature concerning the development of the intervertebral discs controversies exist as to the period of differentiation and structure of the nucleus pulposus and annulus fibrosus. These controversies result from different determination of age of the investigated embryos. Aim. Using embryos from departmental collection age of which was established according to international Carnegie staging and expressed in postfertilizational days, the differentiation of the intervertebral discs was traced. Material and methods. Study was performed on 34 embryos at developmental stages 13–23 (32–56 days). Embryos were serially sectioned in sagittal, frontal and horizontal planes. Sections were stained with various histological methods and impregnated with silver.Results. Division of sclerotomes into loose cranial and dense caudal zones (sclerotomites) was observed in embryos aged 32 days (stage 13). The intervertebral disc developed from the dense zone of sclerotome and was well recognized in embryos aged 33 days (stage 14). At the end of fifth week (embryos at stage 15, 36 days) the annulus fibrosus and the nucleus pulposus were seen. The annulus fibrosus differentiated into lateral and medial zones. Within the lateral zone cells were arranged into circular rows. These rows were considered as the first stage of laminar structure. In further developmental stages the laminae occupied both zones of the annulus fibrosus.Conclusions. The intervertebral discs develop from the dense zone of the sclerotome which is evident in embryos at stage 13 (32 days). Discs differentiate in embryos aged 33 days, when the nucleus pulposus and annulus fibrosus are recognized. In embryos aged 36 days in the annulus fibrosus circular rows forming laminar arrangement are seen.
Effectiveness of regular physical activity on exercise tolerance and biochemical parameters in high-risk prostate cancer patients during radiotherapy
Authors: Hojan Katarzyna , Ozga-Majchrzak Owidia , Górecki Maciej , Leporowska Ewa , Milecki Piotr
Published: April 2021

Introduction. Radiotherapy (RT) is an important modality for curative treatment in high-risk prostate cancer (PCa) patients that improves overall survival, however, it may cause unfavorable changes in physical fitness, increased risk factors for cardiovascular and metabolic complications. The effects of physical exercise on aerobic capacity and on serum levels of liver and renal function indices in PCa patients undergoing RT are still unknown. Aim. The purpose was to assess the impact of supervised physical activity on aerobic capacity, hemorheology and metabolic biomarker levels in high-risk PCa patients during RT. Material and methods. Seventy-two men were randomly allocated to two groups before RT for high-risk prostate carcinoma. Thirty-six men conducted physical exercise (EG) and the other 36 men were a control group (UC). Outcomes measured were 6-Minute Walk Test (6MWT), blood parameters, serum levels of hepatic and renal function biomarkers (urea, creatinine, alanine and aspartate aminotransferase, PSA) in a modified shuttle test before and after RT. Results. After RT, decreased diastolic blood pressure (before test p = 0.05) was observed in the EG and in the UG, there was an increase in resting heart rate (p = 0.017), a decrease in walking distance (p = 0.036), and an increase in Borg fatigue score during the 6MWT. There was no statistically significant change in renal biomarkers or PSA in the liver in either group. Conclusions. Physical activity in prostate carcinoma patients during RT improves capacity tolerance with a decrease in Borg fatigue score, but this activity did not influence on serology outcomes or other blood indicators during RT
The benefits and risks of short-term diet changes on the example of the use a 5-week long lactoovovegetarian diet. Analysis of 7-day nutritional surveys of women – preliminary study
Authors: Czyżewska-Majchrzak Łucja , Krzymińska-Siemaszko Roma , Pelczyńska Marta , Witmanowski Henryk
Published: April 2021

Aim. Due to more frequent incidence of diet related diseases, alternative methods of nutrition become more popular. The aim of this paper is to determine the degree of balance of a short-term lactoovovegetarian diet followed by those who do not have any previous experience with such a diet. Moreover, the study aims at comparing its findings with results of a nutritional analysis carried out in the case of volunteers following a long-term lactoovovegetarian diet.Material and methods. The method chosen in this study is a nutritional analysis based on 7-day long nutritional surveys. Diet 5.0 software was used analyze this data. The tests were conducted among 9 lactoovovegetarians females (LVD – long-term vegetarian diet) and 9 females who decided to follow a lactoovovegetarian diet for the duration of 5 weeks (SVD – short-term vegetarian diet). In the latter case, nutritional surveys were performed in the week preceding the experiment (SVD1/control group) and the last week of the diet (SVD2).Results. In LVD group, when compared with SVD1, significant differences in average daily intake of vitamin E, fat and plant fiber have transpired. After analyzing data from nutritional surveys of SVD2 group, significant differences in the amount of basic nutritional elements (e.g. smaller amount of fat and fiber), microelements (e.g. lower supply of calcium, iron, magnesium) and vitamins (vitamin E, thiamine, niacin) have been noted, as compared to LVD group. When comparing data within SVD group, i.e. a traditional diet and a 5 week long lactoovovegetarian diet significantly lower supplies of vitamins B1, B3, B12 and D were observed than before starting the experiment. Conclusions. A short-term change of eating habits from a traditional diet into a lactoovovegetarian one may result in insufficient supply of numerous nutrients.
Genotoxic impurities in pharmaceutical products – regulatory, toxicological and pharmaceutical considerations
Authors: Regulska Katarzyna , Michalak Marcin , Murias Marek , Stanisz Beata
Published: April 2021

This article provides an overview of the most important aspects around the detecting and reporting of genotoxic impurities in the pharmaceutical industry. It focuses on relevant regulatory, toxicological, and pharmaceutical considerations. In this regard, the concept of Threshold of Toxicological Concern is explained and the most common genotoxic impurities are described. Furthermore, toxicological methods for genotoxic impurities screening are presented. Finally, the article emphasises several issues regarding further development.
The effects of submaximal exercise on a treadmill on the recovery of the stiffness index and reflection index in men with untreated hypertension
Authors: Miętkiewska-Szwacka Kamila , Magdalena Kujawska-Łuczak  , Tomasz Piorunek  , Szczepan Cofta  , Karolina Hoffmann  , Katarzyna Grabańska-Martyńska  , Magdalena Roszak  , Ewa Wysocka  , Maciej Cymerys
Published: April 2021

Aim. Increased arterial stiffness is a risk factor for cardiovascular disease (CVD). Adult men with untreated hypertension are at risk of future CVD. The study aimed to compare the effects of a submaximal exercise on the recovery of the two descriptors of arterial pressure waveform, i.e. stiffness index (SI) and reflection index (RI), between men with untreated hypertension (HA) and healthy peers.
Material and Methods. The study included 70 Caucasian men with untreated primary HA and 30 normotensive men. Blood pressure, SI and RI were determined by photoplethysmography before and 6 minutes after a submaximal (up to 85% of age-predicted maximal heart rate) exercise on a treadmill.
Results. Baseline SI was higher in HA than control men (6.06 [0.66] vs. 6.61 [0.84] m/s; p=0.0019) and remained significantly increased during post-exercise recovery only in HA men (7.59 [1.6] vs. 6.18 [0.85] m/s; p<0.0001). Pre-exercise RI did not differ between HA and healthy men (50.74 [14.17] vs 48.9 [14.86]%). Six minutes after the exercise, RI higher in HA patients than in healthy men (45.26[15.33] vs 36.2 [13.18]%; p=0.0058).
Conclusions. Arterial stiffness is higher in men with HA both at rest and 6 minutes after exercise. Compared with healthy men, those with HA have more increased arterial tone and impaired vasodilation but only during the recovery. It suggests that untreated HA patients have abnormal mechanical properties of arterial pressure waveforms during the post-exercise recovery.
Evaluation of dietary supplement use for the improvement of the condition of skin and its appendages
Authors: Korzeniowska Katarzyna , Cieślewicz Artur , Pawlaczyk Mariola , Pawlaczyk Michał , Jabłecka Anna
Published: April 2021

Introduction. The condition of skin, nails and hair depends on a diet. Proper diet ought to include all components necessary to ensure a well-balanced intake of proteins, fats, carbohydrates, vitamins and elements. Dynamic development of the dietary supplement industry offers an expanding range of products aimed to improve the condition of skin, hair and nails.Aim. To study the issue of using dietary supplements aimed to improve skin and its appendages by men and women (in particular: studying the reason for such supplementation, determining the source of information about the supplements, evaluating the knowledge of the respondents and the effect of the supplements).Material and methods. The questionnaire-based study was conducted in 2013–2014, in a group of 115 people (65 women and 50 men), aged 16–60 years, who had been using dietary supplements designed to ensure proper appearance of the skin, hair or nails. Statistical analysis was carried out using StatSoft Statistica 10.0 software. Results. All participants had been using various dietary supplements for at least 4 months prior to the study commencement. 73% respondents declared that their main aim was to improve the condition of the skin, hair, and nails. The main reason for supplementation was the desire to improve the condition of the hair, reported by 48% of women and 64% of men. Both, women (59%) and men (48%) decided to supplement their diet mainly under the influence of the mass media. Considerable improvement in the condition of the skin and its appendages was observed by 79% of the respondents. Adverse effects were reported by 48% of the participants (with 72% concerning gastrointestinal tract).Conclusions. 1. Information provided by the mass media remains the main cause of purchase and consumption of dietary supplements. 2. Subjective efficiency of supplementation has been confirmed by the majority of the respondents. 3. Approximately half of the studied population reported adverse effects, especially on the gastrointestinal tract.
Ketoprofen, an emerging photoallergen
Authors: Zuba Ewelina Bogumiła , Osmola-Mańkowska Agnieszka , Jenerowicz Dorota , Stawny Maciej , Czarnecka-Operacz Magdalena
Published: April 2021

Introduction. Ketoprofen, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), is an emerging photoallergen. Especially its topical use may be a cause of drug-induced photosensitivity.Material and methods. We report two cases of photoallergic and one case of phototaggravated contact dermatitis due to topical ketoprofen application, confirmed by photopatch testing.Results. All patients presented positive reactions to ketoprofen at an irradiated site. Only one patient demonstrated a positive reaction to ketoprofen both at an irradiated and non-irradiated site.Conclusions. Photosensitive reactions due to topical application of ketoprofen being of significant clinical importance need to be properly diagnosed. It is crucial to provide patients with a detailed instruction how to protect photoexposed areas during therapy with ketoprofen.
Biopharmaceutical evaluation of new semi-solid preparation with thiotriazoline and chloramphenicol
Authors: Zubachyk Volodymyr , Holeyko Marta , Vashchenko Oksana
Published: April 2021

Introduction. Periodontitis numbers among the most widespread diseases. The prevalence of the periodontal inflammation does not tend to decrease, but long-term history of the disease, the complexity in treatment significantly reduce the quality of life in patients, cause the tooth loss. An important principle for the treatment of mentioned disorder is use of drug products in the lesion location. The preference is given to semi-solid preparations with a polyvalent pharmacological action which can eliminate the causative agents and affect the different elements in the pathogenesis.Aim. Aim of the study was to evaluate the influence of excipients, including the base-forming agents, on the thiotriazoline release from semi-solid preparation and based on the results of investigations to develop the composition of a new drug product for treatment of periodontal inflammation.Material and methods. Thiotriazoline and chloramphenicol were selected as active pharmaceutical ingredients for the development of semi-solid preparation. Methylcellulose, carboxymethylcellulose sodium and polymethylsiloxane (base-forming agents); glycerol and propylene glycol (plasticizers); methylparaben and propylparaben (preservative agents); peppermint oil (flavouring agent) were also used in the investigations on the pharmaceutical development. In order to select an optimal composition of the base for dental semi-solid preparation with thiotriazoline and chloramphenicol, six samples with different content were prepared. The appearance of samples was evaluated visually. Measurement of pH value was performed using pH-Meter-240 CORNING. Thiotriazoline release from the test samples was studied in vitro by agar diffusion method.Results and conclusions. The results of investigations showed that excipients largely affected thiotriazoline release from the drug product. According to the results of physical, physical-chemical and biopharmaceutical investigations the following excipients were chosen for the development of dental semi-solid preparation: methylcellulose (base-forming agent), glycerol (plasticizer), methylparaben and propylparaben (preservative agents), peppermint oil (flavouring agent with antiseptic action).Developed preparation is homogeneous mass with a thick consistency, white color and pleasant fresh smell. The drug product is characterized by stable physical-chemical and rheological properties, and has a neutral pH.
Assessment of heparanase and heparin-binding growth and angiogenesis factors in the uterine cavity fluid in women with impaired reproduction
Authors: Wirstlein Przemysław , Mikołajczyk Mateusz , Skrzypczak Jana
Published: April 2021

Introduction. Numerous reports lead to conclusion that either the absence or insufficient amounts of heparanase and heparin binding growth factors on the luminal surface of the epithelium in the endometrium may be associated with impaired reproduction. The aim of this study was to assess the suitability of the fluid from the uterus to predict reproductive disorders. Material and methods. The group consisted of 32 women with 2 or more consecutive unexplained miscarriages, and 33 idiopathic infertility patients; the control group comprised 22 women with normal reproductive potential. Concentration of the studied factors was assayed by ELISA in uterine fluid.Results. The uterine flushings from women with two or more consecutive miscarriages showed significantly lower concentrations of HPA1 (p < 0.001) compared to the control group and infertile patients. In contrast, we didn't observe statistically significant differences of concentration of HB-EGF, VEGF, FGF2 in the studied groups. Statistically significant correlations were obtained between the levels of HPA1 and growth factors in all groups p < 0.05. The ROC curve was used to test the diagnostic value of HPA1. With a cut-off point of 8.56 U/L for HPA1 levels, we achieved 58.6% sensitivity and 84.6% specificity in the detection of women with recurrent miscarriage compared to fertile controls and infertile women combined. The area under curve (AUC) value was 0.751. Conclusions. The procedure for determining the concentrations of HPA1, HB-EGF, VEGF, FGF2 by ELISA in fluids derived from the uterine cavity is insufficient to predict either success of reproduction or reproductive disorders.
Creative Legal Study among Undergraduate Medical Students: Sharing Technique from Mae Fah Luang University
Authors: Jumlongkul Arnon
Published: April 2021

In Thailand, the topic of medical ethics and laws related to medical professions has been one part of the national competency assessment criteria. The objective of this article was to design legal issues into the medical curriculum and to share experiences of creative legal study. Legal contents were inserted into 10 subjects and taught for year 1 to year 6 medical students. Students were divided into multi-groups or received individual tasks and then, shared their knowledge and idea for solving legal problems. The results showed they could interpret and create novel ideas for legal and ethical reconstruction, including the topic of the principle of laws, criminal laws, civil and commercial laws, public health laws, organ donation/transplantation, end of life decisions, and legal liability for the medical profession. Finally, the creative legal study can be used as a novel approach to support creativity among medical students.
Um debate com jovens do Ensino Médio sobre História, memória e racismo
Authors: Thomson Ana Beatriz Accorsi , Zammataro Ana Flávia Dias
Published: April 2021

Este artigo tem como objetivo analisar asideias históricas de alunos do EnsinoMédio sobre eventos recentes de destruiçãode estátuas e monumentos ligados aocolonialismo e ao imperialismo, em diferenteslugares do mundo. A partir deuma atividade proposta remotamente a44 alunos de uma escola periférica deLondrina (PR), como forma de tornar oensino remoto mais crítico e conectado àrealidade atual, analisamos qualitativamenteos dados sob o âmbito teórico--metodológico da Educação Histórica.Foi possível perceber que a maioria dosestudantes considera que a derrubadadas estátuas não leva necessariamente aocombate ao racismo, sendo fundamentaisoutras estratégias de conscientizaçãosocial. Algumas narrativas dos jovensbasearam-se em relatos pessoais sobre oracismo, evidenciando ideias complexasno que se refere à discussão sobre identidadee superação de experiências traumáticas.
Divulgação Científica e Mídias Sociais: a relação entre públicos e história – Entrevista com Joel Paviotti
Authors: Krambeck Isis Muller , Priori Claudia
Published: April 2021

A entrevista com o historiador Joel Paviotti, criador da página Iconografia da História, aborda questões relacionadas aos conteúdos de história  veiculados nas várias redes sociais da página. Discute traços do trabalho de  pesquisa, construções narrativas e   trabalho colaborativo entre  profissionais  de áreas distintas com o intuito de promover divulgação científica da história para públicos e/ou audiências mais ampliadas. Numa autoridade compartilhada, a página Iconografia da História é uma das práticas de história pública que têm sido realizadas no Brasil, como espaço de divulgação de conhecimento histórico e de diálogo com públicos diversos.
Efikasi Beberapa Agens Hayati Terhadap Penekanan Pertumbuhan Pyricularia grisea Secara In Vitro
Authors: Lestari Shyntiya Ayu , Kalsum Umi , Ramdan Evan Purnama
Published: April 2021

The demand for rice as an important food crop in Indonesia is still constrained by the attack of blast disease caused by Pyricularia grisea. Controlling using synthetic chemical pesticides has a negative impact on the environment so that the use of biological agents is an alternative option. This study aims to determine the effectiveness of several biological agents against the pathogen P. grisea that causes blast disease in rice plants in vitro. The study used a completely randomized design (CRD) with 6 levels of treatment and was repeated 3 times using the dooble culture method. The results of the study showed that the inhibition of P. grisea was the highest in the treatment of P. grisea × Trichoderma sp. and P. grisea × Gliocladium sp. namely 67.04% and 51.85% compared to other treatments. The P. polymyxa and P. fluorescence treatments showed low inhibition, namely 23.70% and 28.89%. Biological agents Trichoderma sp. and Gliocladium sp. able to inhibit the growth of the fungus P. grisea. Each biological agent has a different percentage of inhibition in that caused by the inhibitory mechanism of the biological agent.
VOTING BEHAVIOUR AMONG MALAYSIAN STUDENTS IN INDONESIA IN THE 13TH MALAYSIAN GENERAL ELECTION
Authors: Satyawan Ign. Agung , Budiarjo Budiarjo
Published: April 2021

The 13th general election in Malaysia is significant momentum in Malyasian politics. The election held in March 2013 was a testing for Barisan Nasional (BN) the biggest coalition parties led by United Malays National Organization (UMNO) to win the election.  Since 1998, the votes for BN decreased but the votes for the opposition increased. If the BN lost its power in thw 13th election, it will have an impact on domestic political change. It will also bring a change in economic policy. Malaysia's political-economic changes will also take effect on the political-economic of Indonesia given the relations of economic, trade and labor has a substantial aggregate in Indonesian macro economy. The prediction of political-economic change can be seen from the behavior of the voters in 13th election. This study will examine the voting behavior of Malaysian students who are studying in Indonesia. Survey technique is used as the method in this research. In general, students do not exercise their voting rights. There is a possibility that they are reluctant to use their right to vote because most of the respondents started to not respect the country's ruling BN and also do not trust the Election Commission in conducting free and fair elections.

 

Key words: Voting Behavior, General Election, Malaysian Political System, Political Participation
IMPLEMENTATION OF THE NATIONAL COMMUNITY EMPOWERMENT PROGRAM (PNPM) IN PONTIANAK
Authors: Maryuni Sri
Published: April 2021

 

The unsuccessful implementation of national community empowerment program in urban areas (in Indonesia: PNPM) is due to many factors; both internal and external factors. This study aims to acquire insight and understanding a new concept of public policy implementation by applying qualitative descriptive methods. The implementation of PNPM program was involving many elements including: implementer, the program itself, the target groups and environment. 

The results revealed that the unsuccessful implementation of PNPM in Pontianak was caused by the idealized policy (program), the target groups, the implementing organization (implementer) and environmental factors. The four factors mentioned before were interrelated and influenced each other to form a policy cycle. In implementing this program, the approach used was the empowerment of communities to establish independence of the community and local government agencies that were facilitated by community self-reliance organization. In reality it is very difficult to encourage the poor to participate in the planning and implementation of this empowerment program. For that reason, the community volunteers had to work hard to gain the aspirations of poor communities through Citizen Preparation Meeting (in Indonesia: Rembug Kesiapan Warga) and Development Planning Meeting (in Indonesia: Musyawarah Perencanaan Pembangunan).

 

Keywords: Implementation, Empowerment, Independence, Voluntary
BUREAUCRACY REFORMS ON THE SYSTEM DIMENSIONS AND PROCEDURES IN KUPANG CITY GOVERNMENT INTEGRATED LICENSING SERVICES
Authors: Djani William
Published: April 2021

 

This aim of this paper is to propose solutions to the systems and procedures reform, as part of the bureaucratic reform, in the City of Kupang. Generally, Indonesian bureaucracy has undergone significant reform, which is the result of convergence between external and internal factors. Bureaucracy Reform of the bureaucracy can be classified into three groups: institutional reform, personnel resources reform and systems and procedures reform. In many cases, the failure of system and procedures reform has hindered the effectiveness of bureaucracy reform as a whole. Therefore getting insight on the government commitment to promote system and procedure reform is imperative. This study discusses Kupang City government commitment to reform the system and procedures.

 

Keywords: Bureaucracy, System and Procedure Reform, Public Services. 
CAPACITY BUILDING: GOVERNANCE PERSPECTIVE ON WASTE MANAGEMENT UNIT IN SRAGEN BUNDER MARKET
Authors: Setyowati Kristina , Gunawan Didik , Ansoriyah Faizatul
Published: April 2021

 

Public waste has become national problems. As part of solving the problem the management of public waste needs to be comprehensive and integrated so the processed public waste able to provide economic benefits, healthy for people, safe for the environment and not to forget also able to change people's behavior. Governance perspective is involving three pillars: government, private and citizens. In this study this parties were represented by Sragen Regency Government as government, Danamon Peduli Foundation as private and small scale vendors as citizens. All of which were expected to bring effectiveness in empowering waste management unit. Partnership and capacity building are expected to strengthen the knowledge as well as managerial capability and capacity in the traditional market waste management. This article aims to describe the waste management with governance perspectibe in Bunder traditional market, Sragen, Indonesia.

 

Keyword: Empowerment, Capacity building, Governance
THE CITY UTILIZATION MANAGEMENT CASE STUDY OF LAND USE DYNAMICS AND ECONOMIC GROWTH IN BANDAR LAMPUNG CITY
Authors: S. Bambang Utoyo
Published: April 2021

In the future, the urban area will be the area that gets more complex, covered by a variety of social, economic and environment arising from population growth in the region and in line with the dynamics of globalization, democratization and decentralization. The purposes of this study is to describe and analyze the dynamics of land use and growth in the area for 1 (one) a decade in Bandar Lampung.

               This research is a descriptive study using documentation for secondary data obtained from the BPS at two (2) different time points (t0 and t1). The analysis model used to assess the focus of research using quantitative analysis Location Quotient (LQ) and Shift-Share Analysis (SSA).

               The results showed that: (1) During a decade in Bandar Lampung has occurred the utilization land for industrial use; settlements and services were increasingly widespread. While the use of land that is not cultivated; swamps and forests tend to be diminishing at a rate; patterns and impact varied in each parts of the city; (2) For almost a decade of economic growth in Bandar Lampung supported by sectors of the economy outside agriculture and mining and quarrying. While in the long term competitiveness of economic growth in the city was supported by the agricultural sector; Non-oil processing industry; and finance, leasing and services company. And the third (3) factors of economic growth, population growth and government policy in the form of spatial planning as well as the entry into force of the market mechanism was a trigger factor that reflected changes in land use in urban areas.

               The suggestions and recommendations as well as follow up on the policy implications that can be done in Bandar Lampung, including : changing the necessary incentives and dis-incentives policy in controlling land utilization, giving the opportunity cost that owned land resources, both economic and non -economic. Additionally, in efforts to achieve sustainable urban development, expansion of public access required in determining the allocation of land use and the provision of public space is increasingly widespread and qualified as a form of services provided by the municipality to citizens.
Implementasi Strategi KPP Pratama Surakarta dalam Meningkatkan Pengguna E-filing di Kota Surakarta
Authors: Nugroho Rino A. , Abraham Christoper Danesh
Published: April 2021

Penelitian ini berkaitan tentang implementasi strategi yang dilakukan oleh KPP Pratama Surakarta yang bertujuan untuk meningkatkan pengguna e-filling di Kota Surakarta. Direktorat Jendral Pajak telah menetapkan rencana strategis yaitu migrasi wajib pajak untuk beralih menggunakan e-filling. Dalam pelaksanaan atau implementasinya di tingkat kota Surakarta, KPP Pratama Surakarta diwajibkan untuk mensukseskan migrasi tersebut. Jika dilihat dari tujuannya, penelitian ini bersifat deskriptif.Adapun teknik pengumpulan data yang digunakan pada penelitian ini adalah wawancara dan dokumentasi.Sedangkan untuk penentuan informan, peneliti menggunakan purposive sampling, dan validitas data dilakukan menggunakan triangulasi data.Selanjutnya untuk menganalisis data yang diperoleh, peneliti menggunakan model analisis interaktif dari HB Sutopo.penelitian ini menunjukkan bahwa, implementasi strategi KPP Pratama Surakarta untuk meningkatkan pengguna e-filling di Kota Surakarta, diutamakan pada kegiatan sosialisasi demi mensukseskan migrasi wajib pajak dan mencapai target sebesar 65%. Adapun kegiatan sosialisasi yang dilakukan dibedakan menjadi dua jenis, secara langsung maupun tidak langsung. Anggaran yang  digunakan oleh KPP Pratama Surakarta telah ditetapkan oleh Direktorat Jendral Pajak. Anggaran tersebut dapat diubah dengan caraswitch change sesuai kebutuhan. Dalam pelaksanaan prosedurnya, KPP Pratama Surakarta lebih mengutamakan turun langsung kedaerah kantong-kantong wajib pajak sesuai perintah kepala KPP Pratama Surakarta.Sedangkan aspek sosial, KPP Pratama Surakarta telah menyediakan sekitar 20 komputer yang terhubung intrnet dan menyediakan pembimbing untuk melayani wajib pajak untuk melakukan pengisian form e-filling secara online.
Kata Kunci: E-filling, Migrasi wajib pajak, Implementasi Strategi
Inovasi Kebijakan dalam Perspektif Administrasi Publik Menuju Terwujudnya Good Public Policy Governance
Authors: Sururi Ahmad
Published: April 2021

Kebijakan publik sebagai instrumen yang mensinergikan peran pemerintah dan publik belum berjalan secara optimal. Terjadinya fenomena beberapa kebijakan yang dibatalkan atau direvisi oleh Pemerintah merupakan indikasi masih adanya tumpang tindih kebijakan dan rendahnya kemampuan berinovasi (ability to innovate) dan kemauan berinovasi (willingnes to inovate) pejabat publik. Untuk itu diperlukan inovasi kebijakan yang secara substantif dapat memberikan penguatan dalam menyelesaikan permasalahan ditengah masyarakat. Tujuan dalam penelitian ini adalah untuk mendeskripsikan dan melakukan analisis bagaimana inovasi kebijakan dalam perspektif pendekatan administrasi pubik dan menganalisis inovasi kebijakan menuju terwujudnya good public policy governance. Metode yang digunakan adalah pendekatan kualitatif. Teknik yang dilakukan adalah survei literatur akademis di bidang keilmuan kebijakan publik guna memperoleh konsep-konsep yang relevan dengan kajian inovasi kebijakan publik. Teknik pengumpulan data melalui penelusuran berbagai sumber dan literatur baik dari dokumen pemerintah maupun pemberitaan media massa cetak dan elektronik, jurnal dan buku-buku yang terkait dengan administrasi pubik dan inovasi kebijakan. Penerapan prinsip-prinsip inovasi melalui NPS adalah representasi dari penerapan inovasi kebijakan. Publik dipandang secara utuh, manusiawi dan humanis melalui pendekatan yang memberikan space kepada publik untuk berkolaborasi dan berorientasi pada peningkatan kinerja. Good public policy governance akan terwujud melalui pendekatan 1) Jenis dukungan; 2) Manajemen Inovasi; 3) Karakteristik dalam penerapan nilai.
Kata Kunci : Inovasi Kebijakan, Administrasi Publik, Good Pubic Policy Governance
Reformasi Manajemen Aparatur Sipil Negara: Evaluasi Peran Pejabat Pembina Kepegawaian dan Komisi Aparatur Sipil Negara
Authors: Katharina Riris
Published: April 2021

Reformasi birokrasi di Indonesia yang dilakukan melalui Undang-Undang Nomor 5 Tahun 2014 tentang Aparatur Sipil Negara hingga saat ini belum memperlihatkan hasil maksimal. Maraknya kasus jual beli jabatan oleh kepala daerah menjadi salah satu indikatornya. Tulisan ini menjawab permasalahan mengapa jual beli jabatan masih terjadi padahal sudah ada KASN yang dibentuk untuk menegakkan sistem merit dalam tubuh ASN. Metode penelitian dilakukan melalui pendekatan kualitatif. Data diperoleh melalui studi literatur  dan selanjutnya dianalisis dengan menggunakan pemikiran model hubungan birokrasi dan politik. Tulisan ini berargumen bahwa sepanjang pejabat pembina kepegawaian masih diemban oleh pejabat politik, sepanjang itu pula ketergantungan birokrasi kepada politik sangat besar. Hal ini akan mengakibatkan permasalahan dalam netralitas politik dan menimbulkan birokrasi yang tidak profesional. Dampak negatifnya akan dirasakan oleh masyarakat sebagai penerima layanan dari para birokrat. Tulisan ini merekomendasikan agar peran pembina kepegawaian diserahkan kepada pejabat karier birokrasi melalui revisi UU ASN. KASN harus dapat memastikan bahwa setiap birokrat akan menjalankan perannya sebagai pelaksana dari setiap kebijakan yang ditetapkan oleh pejabat politik. Dengan demikian, akan dihasilkan ASN yang profesional dalam melaksanakan tugasnya, yang dapat mewujudkan tata kelola yang efektif.
Implementasi Kebijakan Kabupaten Layak Anak di Kabupaten Pringsewu
Authors: Sulistiowati Rahayu , Prihantika Ita , Atika Dewie Brima , Prihantika Ita , Sari Yuni Ratna
Published: April 2021

Kekerasan terhadap anak yang meningkat dari tahun ke tahun direspon oleh Kabupaten Pringsewu dengan mengeluarkan Peraturan Daerah Nomor 17 tahun 2016 Tentang Penyelenggaraan Kabupaten Layak Anak di Pringsewu. Penelitian ini bertujuan untuk mendeskripsikan implementasi kebijakan penyelenggaraan kabupaten layak anak di Kabupaten Pringsewu Provinsi Lampung. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif deskriptif. Analisis dilakukan dengan menggunakan model implementasi kebijakan dari Edward III. Hasil penelitian menunjukkan bahwa diukur dari variabel komunikasi, sumber daya, disposisi, dan struktur birokrasi, penyelenggarakan kebijakan kabupaten layak anak belum dilaksanakan secara optimal. Peraturan Daerah yang merupakan payung tertinggi di tingkat kabupaten tidak diikuti dengan peraturan dan kebijakan turunan yang seharusnya mendukung peraturan daerah tersebut. Disposisi merupakan variabel penting dalam kebijakan Kabupaten Layak Anak yang menjadi simpul pengikat variabel lainnya. Penelitian lanjutan dapat dilakukan dengan mengambil fokus pada perilaku waktu dan identifikasi variabel-variabel lain yang menjadi umpan balik kebijakan ini.

Kata kunci: implementasi kebijakan, Kebupaten Layak Anak, kekerasan terhadap anak.
Mempertanyakan Pengelolaan Publicness pada Kawasan Malioboro-Ahmad Yani di Tengah Dominasi Perekonomian
Authors: - Fadlurrahman , Ikhtiara Seiren , Fauziah Nike Mutiara , - Amaliatulwalidain
Published: April 2021

Penelitian ini bertujuan untuk mendeskripsikan pengelolaan publicness yang dilakukan oleh pemerintah Kota Yogyakarta melalui UPT Malioboro. Dengan metode kualitatif dan pendekatan studi kasus, ditemukan bahwa: (1) Pengelolaan publicness mengalami tekanan yang kuat dari pasar; (2) Eksistensi publicness dikelola dengan cara negosiasi kepentingan; (3) Otoritas pemerintah turut melemahkan derajat publicness ketika adanya tekanan dari kelompok ekonomi; (4) Publicness tereduksi ketika minimnya peran dan kontrol pemerintah; dan (5) Derajat publicness meningkat pasca adanya relokasi parkir kendaraan. Saran yang ditawarkan yaitu  pemerintah perlu memperkuat komitmen untuk mengelola kawasan Malioboro-Ahmad Yani yang berorientasi pada kepentingan publik. Selain itu pemerintah perlu memprediksi perkembangan kelompok-kelompok ekonomi dan menciptakan sistem antisipasi/solusi tanpa melemahkan publicness.  

Kata kunci : Publicness, kelompok ekonomi, Malioboro
PENGEMBANGAN POTENSI EKONOMI PESISIR KABUPATEN GUNUNGKIDUL BERBASIS INTERCONNECTED GOVERNANCE
Authors: Pinandito Tito Satria , Asfiani Nurul , Mardziyah Ainun , Pawestri Novarenda
Published: April 2021

Ketimpangan sosial masih menjadi fenomena yang terjadi di berbagai daerah di Indonesia. Kesenjangan yang paling kontras terlihat antara daerah perkotaan dan pesisir. Hampir sama dengan teori yang dikemukakan oleh Myrdal, wilayah pesisir cenderung tertinggal karena jaraknya dari pusat kota. Berdasarkan pengamatan yang dilakukan, ditemukan bahwa ada 35 daerah tertinggal yang tersebar di Propinsi Daerah Istimewa Yogyakarta, termasuk daerah pesisir di Kabupaten Gunungkidul yang meliputi Kabupaten Panggang, Saptosari, Tanjungsari, dan Girisubo. Setelah melakukan pengamatan, peneliti menggunakan metode berpikir lintas dengan pembandingan. Tujuan menggunakan metode ini adalah untuk mengambil poin-poin keunggulan yang telah berhasil diterapkan oleh suatu daerah yang kemudian titik-titik ini juga dapat diterapkan di daerah lain yang terbelakang. Berdasarkan uraian masing-masing parameter, penulis menetapkan Desa Ngloro sebagai lokasi penelitian karena dianggap sebagai desa yang paling dirugikan dibandingkan dengan yang lain. Kemudian para peneliti menetapkan Pulau Osi sebagai wilayah pembanding. Hasil dari penelitian ini adalah bahwa peran semua pemangku kepentingan, terutama sebagai lembaga perencanaan pembangunan nasional, BAPPENAS memiliki porsi yang lebih besar dalam menyiapkan rencana pembangunan jangka panjang dan menengah. Karena itu, dalam upaya menyamakan pembangunan nasional, wilayah pesisir nusantara perlu mendapat perhatian.
INTEGRATION ZONE DEVELOPMENT IN BUREAUCRATIC REFORM
Authors: Haryani Tiyas Nur , Puspasari Apriana
Published: April 2021

Bureaucracy in Indonesia can be said as not optimal yet, so that there is still massive increase in corruption crime rate. Therefore, government conducts bureaucratic reform to reduce corruption practice. This research aimed to describe the implementation of bureaucratic reform in the attempt of suppressing corruption crime rate occurring in the organization of government in Indonesia. Analysis was conducted using library study providing descriptive qualitative data. Considering the data obtained from library study, it could be seen that Ministry of State Apparatuses Empowerment and Bureaucratic Reform has issued integrity zone policy in realizing corruption-free region (WBK)/ clean, catering-on bureaucratic region (WBBM).

There are some important points in integrity zone development: change management, management arrangement, human resource management arrangement, accountability reinforcement, and public service quality improvement. Integrity zone policy is expected to give implication to the reduced corruption crime in government organization