bluuebunny/crossref_metadata_2025 huggingface dataset:
Büyük Erkekler Serbest Güreş 2019 Yılı Avrupa Ve Asya Şampiyonalarının Skor Ve Teknik Analizleri Yönünden Kıyaslanmaları
Authors: ÜNVER Rafet
Published: June 2023

Erkekler Serbest Stil Güreş Müsabakalarında 2016 ve 2021 Olimpiyat Oyunları ile 2021 yılı Erkekler Serbest Stil Dünya Güreş şampiyonasında en fazla madalya kazanan Avrupa ve Asya kıtası ülkeleri olmuştur. Bu çalışmanın temel amacı Erkeler Serbest Stil Güreş Müsabakalarında en üst düzey performans gösteren bu iki kıtada düzenlenen 2019 kıta şampiyonalarının skor ve teknik analizler açısından benzerlik ve farklılıklarını belirlemektir. 2019 Erkekler Serbest Stil Avrupa Güreş Şampiyonasında 35 farklı ülkeden 173 sporcu 204 müsabakada mücadele ederken, 2019 Erkekler Serbest Stil Asya Güreş Şampiyonasında 23 farklı ülkeden 130 sporcu 153 müsabakada mücadele etti. Avrupa kıtası güreşçileri 1856 teknik puan kazanırken Asya kıtası güreşçileri 1389 teknik puan kazanmışlardır. Şampiyonalardaki tüm sıkletler dikkate alındığında Avrupa Şampiyonasında müsabaka başına teknik puan ortalaması 9,10 olurken Asya Şampiyonasında 9,08 olmuştur. Şampiyonalar arasında müsabaka başına ortalama teknik puan yönünden fark gözlenmemiştir (p>0.05). Müsabakaların kazanılma kriterleri yönünden sayı ile galibiyet kriterinde Avrupa Şampiyonası lehine anlamlı bir fark gözlenmiştir (p0.05). Kazanılan teknik puanların frekansları yönünden 1 puan kazanımında Avrupa Şampiyonası lehine anlamlı bir fark gözlenmiştir (p
Basketbolcularda Statik Isınma Egzersizlerinin Dikey Sıçrama Ve Denge Performansina Akut Etkisinin İncelenmesi
Authors: SARIKAYA Mehmet , KILINÇARSLAN Gökmen , KAYANTAŞ İdris , AVCI Pelin , BAYRAKDAR Akan
Published: June 2023

Bu araştırma basketbolcularda statik ısınma egzersizlerinin dikey sıçrama ve denge performansına akut etkisinin belirlenmesi amacıyla yapıldı. Araştırmanın örneklem grubunu Bingöl ili, Gençlik ve Spor Hizmetleri spor kulübünde, en az iki yıl lisanslı olarak basketbol oynayan yaş ortalaması 14,86±,83 (yıl), boy ortalaması 1,68±,09 (cm), vücut ağırlığı 52,79±7,20 (kg), BKI ortalaması 18,60±1,57 (kg/cm2) olan toplam 15 erkek basketbolcudan oluşturuldu. Sporculara ısınmak için 5 dakika hafif tempo koşu uygulandıktan sonra 5 dk boyunca statik germe uygulandı. Dikey sıçrama performansı için CMJ (Countermovement Jump) testi ve SJ (Squad Jump) testi, denge performansını belirlemek için statik ve dinamik denge testi, bacak kuvveti ölçümleri uygulandı. Değerlendirme sonucuna göre basketbolcuların CMJ ve SJ değerlerinin grup içi karşılaştırmalarında p
Do The Non-Verbal Behaviors of Sprinters Before The Competition Affect Their Performance
Authors: ERKAN Dilara , BAYRAKTAR Işık , BİÇER Ayşe Sibel
Published: June 2023

In athletics, the athlete is expected to get their concentration and control his negative emotions before the start. Body language of athletes can give important clues about their "real" internal states. On account of, it is important to analyze the nonverbal behaviors of the athletes before the start. In line with this importance, the aim of this study is to analyze the pre-start nonverbal behaviors of the athletes by coding them with the "Body Action Posture Coding System" and to examine the effect on the performance of the athletes. As a result, with this thesis study, it has been revealed that some nonverbal behaviors of the athletes, affect their performance. Nonverbal behaviors can give clues about the mental state of the athlete as well as give clues about the result of the competition has been opened to discussion with this study.
Time, Law, and Tech: The Introduction of Algorithms to Courts of Law
Authors:   , Hedler Luisa
Published: June 2023

This dissertation examines how the legal system perceives the introduction of algorithms in courts as a means of handling the demands of time, efficiency, and risk. As technologies like natural language processing and machine learning develop, algorithms can be used to read and process enormous quantities of data, thus opening the possibility of automating tasks once considered solely performed through human thought. Within a social context of hyper-connectivity and accelerating social processes, the judiciary, as part of the legal system, is usually represented as inefficient, too slow and too expensive – and thus a field ripe for the application of technological solutions. In recent years courts have been incorporating algorithms into their functioning to varying degrees, with the Brazilian Judiciary counting among those enthusiastically developing, testing, and implementing in-house solutions to tackle its enormous caseload. Starting from a systems-theoretical standpoint, this monograph observes how the legal system is self-described in the accounts produced by the Brazilian Superior Court of Justice (STJ) and the National Council of Justice (CNJ) as they communicate about their technological initiatives.
CFD SIMULATION OF PRESSURIZATION SYSTEM IN FIRE STAIRS WTC 6 BUILDING
Authors: Arif Salahudin , Sundari Rita , Anggraini Rini
Published: June 2023

Pressurization system in fire stairs is required for high-rise building for safety evacuation in fire attack. This paper has highlighted on the problem of WTC 6 high-rise building with 18 floors related to safety evacuation in fire attack. In real situation, the minimum air pressure (12.5 Pa) at closed condition and minimum air velocity (1 m/s) at open door chamber in fire stairs as stated in the SNI 03-6571-2001 requirements are not fulfilled by the WTC 6 high-rise building. Therefore, a CFD (Computational Fluid Dynamics) simulation has been used to overcome the problems. The CFD results show that volumetric air flow rate of 7.24 m3/s injected to fire stairs in multiple injection system yielded pressure difference of 39.5–44.7 Pa and air velocity of 1.1–1.2 m/s. The CFD simulation implemented in real situation yields air pressure difference of 38.2 Pa in closed condition and air velocity in open door chamber of 1.16 m/s assumed to solve the problem.
STUDY ON PARAMETERS IN COUNTER CURRENT DOUBLE PIPE HEAT EXCHANGER APPLYING CIRCULAR TURBULATOR
Authors: Sudiono Sudiono , Sundari Rita , Anggraini Rini
Published: June 2023

Many industries dealing with manufacturing and HVAC (heating, ventilation, and air cooling) are rely heavily on thermodynamics principles with respect to heat and mass transfer. The objective of this study is to do optimization to yield optimum heat transfer rate and minimized pressure drop with regard to number of circular turbulator (CT) and water debit on Nusselt number (Nu) in counter current double pipe heat exchanger. This work has applied the classical rule of thermal science dealing with Nusselt number in relation to convection and conduction of heat transfer rate due to temperature effect. The result shows the highest Nu found to be 835.3 at 5 CT and water debit of 9 L/min. The addition of CT number gives effect on fluid current due to vortex generation. This study also investigates the effect of CT number on friction coefficient that the friction coefficient of a heat exchanger in the absence of CT is lower than that in the presence of CT. For any CT number, the friction coefficient is reduced with increasing water debit. The study has also found that the thermal performance ratio has achieved higher values for heat exchanger in the absence of CT.
Rational design core-shell Co@CuCo/Al2O3 catalysts for Low-Temperature Hydrodeoxygenation of 5-Hydroxymethylfurfural
Authors: Zhang Fengyu , Wu HuiFang , Wang Qian , Li Dianqing , Feng Junting
Published: June 2023

Reducing catalyst costs and reaction energy consumption is a potent way
to advance biorefinery energy from fundamental research to industrial
implementation. Herein, we developed a series of low-cost CuCo/Al2O3
catalysts for hydrodeoxygenation of 5-hydroxymethylfurfural to biofuel
2,5-dimethylfuran (DMF). Combined characterizations showed CuCo alloy
and Co@CuCo core-shell structures were successfully constructed by
reducing layered double hydroxides (LDHs) at different temperatures.
Detailed catalytic performance studies found that Co@CuCo catalyst
achieved a decent DMF yield of 91.7% under 130 oC and 1MPa H2, which is
milder than most literatures. While the CuCo alloy catalyst only gave
23.2% yield. H2-TPD and In-situ-IR indicated the CuCo-alloy shell can
prevent oxidation of Co core, so that maintain its high H2 dissociation
capacity. Moreover, the electronic structure changes in the Cu-Co alloy
promote the hydrolysis of C-O bond. Hence, the local atomic arrangement
and corresponding electronic structure in the Co@CuCo structure jointly
strengthened the low-temperature reactivity.
IL-4 producing MAIT cells support antibody production in the peripheral blood of Heonch-Schönlein purpura patients
Authors: Jin Tengchuan , Liu Muziying , Yang Ziqiang , Yang Yunru , Zhao Dan , Cheng Qingyu , Fu Sicheng , Li Yajuan , Liu Gengyuan , Zhao Changfeng , Pan Jun , Wu Qielan , Zhang Yuwei , Bai Li , Deng Fang
Published: June 2023

Background To investigate the phenotype and function of
mucosal-associated invariant T (MAIT) cells in the peripheral blood of
patients with Henoch-Schönlein purpura (HSP), owing to the lack of
evidence on the role of MAIT cells in HSP. Methods Blood
samples from patients with HSP and healthy donors (HDs) were assessed by
flow cytometry and single-cell RNA sequencing (scRNA-seq) to analyze the
proportion, phenotype, and function of MAIT cells. We analyzed
Th-cytokines in the serum of patients with HSP by cytometric bead array
(CBA). IgA in cocultured supernatant was detected by CBA to analyze
antibody production by B cells. Results We found that the
percentage of MAIT cells in patients with HSP was significantly reduced
compared with that in HDs. HSP MAIT cells displayed activation phenotype
with up-regulated CD69, FOS, and JUN, indicating that these cells were
in the early stage of development. HSP MAIT cells also displayed a
Th2-like profile with the capacity to produce interleukin (IL)-4 and
IL-5. We also demonstrated that IL-4 was correlated with IgA levels in
the serum of patients with HSP. Additionally, CD40L was up-regulated in
HSP MAIT cells, and CD40L+ MAIT cells showed an enhanced ability to
produce IL-4, leading to IgA secretion in patients with HSP.
Conclusion Our data demonstrate that MAIT cells in patients
with HSP exhibit an activated phenotype. The IL-4 production of CD40L+
MAIT cells in patients with HSP could take part in the pathogenesis of
HSP and this finding suggested that targeting MAIT cells may constitute
an attractive strategy for HSP.
The Effects of Individualized PBS on Classroom Disruptive Behaviors of Students with Intellectual Disabilities in a Special School
Authors: Kim Junggi , Han Sangmin , Park Eunsu , Kwon Hyuksang , Baek Unmi , Paik Eunhee
Published: June 2023

The purpose of this study was to examine the effects of the individualized positive behavior support on problem behaviors of two special school students with intellectual disabilities. The participants were students with intellectual disabilities who received education in grade 3 in a special school. The study utilized multiple baseline design across subjects, and measured behaviors using partial interval recording. Functional behavior assessment was also conducted using direct observation, interviews with the teacher, and with motivational checklist (MAS). Student’s personal profiles were analyzed to identify the function of the behavior. The dependent variables were the classroom disruptive behaviors demonstrated by students during class: out of seat behavior, making noise verbally, banging the desk, chatting with peers during the instruction, and lying down on the floor. The findings from the study indicated that the individualized positive behavior supports (i.e., antecedent strategies, alternative behavioral strategies, and consequent strategies) were helpful reducing disruptive behaviors of the two students during both intervention and maintenance phase. The implication included the guidelines for future research and limitation.
A Descriptive Analysis of Research on Universal Positive Behavior Support in Korean Journal
Authors: Choi Hayoung
Published: June 2023

Positive Behavior Support has been emerging with concerns regarding how to addressing behavior problems in schools. This study investigated studies implemented schoolwide and classwide positive behavior support in elementary, middle, and high schools. Through Korean academic databases, 9 research articles published in Korean journals from 1997 to 2017 were identified, and these were analyzed based on three analysis frameworks: general characteristics, implementation stages and utilized intervention strategies. The results showed that schoolwide positive behavior support were implemented in 3 studies, and classwide positive behavior support were conducted in 6 studies. As a result of analyzing the implementation stages of positive behavior support on the universal level, mostly special teachers, general teachers, and researchers participated in the positive support implementation team and held teacher education and regularly held team meetings for high fidelity performance. Thirdly, intervention strategies using universal positive behavior support include restructuring the environment, setting expected behaviors, direct teaching expected behaviors, self-monitoring and evaluating, and implementing reinforcement system. Based on the results of this study, discussion and future directions for research were suggested.
A Meta-Analysis of Problem Behaviors for Students with Developmental Disabilities
Authors: Choi JinHyeok , Kim Minyoung
Published: June 2023

The main purpose of this study was to analysis trends in single-target studies that mediate problem behavior for students with developmental disabilities and to focus on whether to perform functional behavioral assessments. In this study, 74 single-target research papers published in the Korean Special Education Journal from 2008 to 2018 were selected as analytical papers. As a result of the analysis, the journal of problem behavioral interventions in students with developmental disabilities continued to increase. The study subjects showed the highest number of elementary school students, regardless of whether a functional behavioral assessment was conducted. The research environment was most often performed in special schools in the case of papers conducting functional behavioral assessments, and papers that did not perform functional behavioral assessments were performed the most in treatment agency. Research design was the most common use of the multiple baseline design that performed functional behavioral evaluations, as well as those that performed functional behavioral evaluations. Indirect assessment mainly conducted in the papers that performed functional behavioral evaluation was a literature review, MAS. Direct assessment was the most used ABC record. Independent variability in the papers conducting functional behavioral evaluations was mainly an intervention package, and studies that did not conduct functional behavioral evaluations were analyzed as being used by a variety of independent varians. Dependents were most often disturbed behavior in papers conducting functional behavioral assessments, and the non-functional behavioral assessment showed the highest proportion of homomorphic behavior. Based on the results of these analyses, we discussed and suggested the future direction of research.
The Effects of Individualized Positive Behavior Support on Requesting Behavior and Classroom Disturbance Behavior of a Student with Autism Spectrum Disorder
Authors: Lee Surnhee , Lee Kwangrim , Seo Younghee , Paik Eunhee
Published: June 2023

The purpose of this study was to investigate the effects of an individualized positive behavior support on requesting behavior and classroom disturbance behavior of autism spectrum disorder in inclusive elementary school. Subject of this research was a student with autism spectrum disorder in special classroom. Individualized positive behavior support was implemented using multiple baseline design across settings. The intervention especially included the student’s choice making of task activity, picture exchange and requesting gesture as well as solving the sleep problem at home using parent notice. The results showed that challenging behaviors like loud noise and hitting of the target student were significantly reduced and the communication behaviors of requesting increased through the individualized positive behavior support. The results of this research showed that individualized positive behavior support reduced challenging behavior and increased requesting behavior for a student with autism spectrum disorder.
The Effects of Individualized Positive Behavior Interventions and Supports (PBIS) on Class Engagement of a Student with Intellectual Disabilities*
Authors: Kang Youngmo , Kang Yunmo , Son Seung Hyun
Published: June 2023

This study was conducted to find out the effects of individualized positive behavior interventions and supports (PBIS) on class engagement of a student with intellectual disabilities. The participant was a post-secondary student with intellectual disabilities in a special school. Observed target behaviors were on-task behaviors and disrupting behaviors during the class. The interventions were individualized PBIS, which were consisted of team building, use of functional behavior assessment (FBA), hypothesis developmental, behavior intervention plan (BIP), and behavioral skills training (BST). Multiple baseline design across settings was used to examine the effects of PBIS on class engagement. The class was recorded using video for 30 minutes, excluding 5 minutes of the beginning and end of the class. Target behaviors were recorded using time sampling in 15 intervals and calculated in occurrence rate. Overall, The results of the visual analysis found that PBIS with implementation was effective to improve on-task behaviors and reduce disruptive behaviors during the class. This effect was also maintained after a certain period. Discussions, limitations, and future researches were suggested.
Current status of behavior analysis-related courses in domestic special education teachers training colleges: basic discussion to prepare criteria for qualification for a bachelor's degree program in behavior analysis experts
Authors: Kim Yeonjoo , Park So-young , Yoo Jang Soon , Baek Jongnam
Published: June 2023

The purpose of this study was to obtain implications for preparing Korean Behavior Analyst Certification by analyzing the subjects related to behavior analysis at special education teacher training that reflects the qualification standards of bachelor's degree program, which has recently been increasing interest in Korea. We analyzed the curriculum posted on the department's website for 46 departments of 31 universities with special education departments among universities that are special education teacher training institution of nationwide. The results of the study are as follows. First, 23 out of 31 colleges (74.2%) have both behavioral analysis principles and clinical practice courses in the department (major) for training teachers in special schools nationwide. Second, 49 subjects related to behavioral analysis principles were opened in the National Special School Teacher Training Department (major), and mainly consisted of 3 credits for elective major, with subject names such as ‘Behavioral modification’, ‘Positive Behavior Support’, and ‘Special child behavior modification’. Third, 123 subjects related to clinical practice were opened in the department (major) for training teachers in special schools nationwide, and mainly consisted of 3 or 2 or less credits for elective major and teaching profession, with subject names such as ‘Educational volunteer activities’, ‘School field practice’, ‘Educational volunteer activities’, and ‘Special education field practice’. According to the results of this study, in order to prepare a bachelor's degree course for behavioral analysis specialists, the necessity of opening additional courses related to behavioral interventions to strengthen the professional competence of preliminary special education teachers was discussed.
The effect of self-management strategies using tablet PC on class participation behavior of elementary school students with intellectual disabilities
Authors: Jeon Hyeonsuk , Leepark Hyesuk
Published: June 2023

The purpose of this study was to investigate the effect of self-management strategies using tablet pc on class participation behaviors of elementary school with intellectual disabilities. The subjects of the study were 3 elementary school students with intellectual disabilities enrolled in special classes at general schools, and the target behavior was class participation behavior defined as attention-concentration and task performance behavior. As an independent variable, a self-management strategy which included self-monitoring, self-evaluation, and selecting reinforcers was applied using a tablet PC and a smart watch. Multiple baseline across participants design was used for the research design. The study was carried out in the order of baseline, intervention and maintenance. Class participation behavior was measured using a whole interval recording and accuracy of task performance, event recording. The intervention was conducted during literacy classes and generalization of the behavior change was tested during math classes. As a result of the study, the incidence of class participation behavior and accuracy of the task performance increased. The intervention effect was maintained even after the intervention was terminated and generalized.
Review of the fidelity measures in universal behavioral supports
Authors: Kim Jerin
Published: June 2023

The purpose of this study is to review the fidelity measures in school-wide positive behavioral interventions and supports; SWPBIS) with an emphasis on their instrumental characteristics and contents. A total of eight instruments, both domestically and internationally developed, were chosen and reviewed in terms of the purpose, the methods of assessment, the criterion scores on adequacy, the composition, and the accessibility. Also, through the in-depth investigation of the item contents (from 258 items), core and sub-elements were identified, and all relevant items within a specific core element were reviewed according to three dimensions including exposure of the intervention, quality of the intervention providers, and responsiveness of the intervention recipients. As a result, the fidelity measures in the universal behavioral supports are used in a school or research and provide multiple functions (e.g. school teams’ use for the regular implementation monitoring, survey of school faculty and staff’s perception) with varied assessment methods. To enhance the user’s understanding, most measures serve different types of information (e.g., measurement, scoring, utilization methods) and materials (e.g., data collection form, action plan form) in addition to the rating scales and are open to the public at no cost through relevant websites or research publications. Also, the review of the item contents found 10 core elements(e.g., defining and teaching the expected behaviors) and 60 sub-elements (e.g., defining the expectations and rules in a clear and positive manner), and those elements were measured evenly in all three dimensions. In the end, the study provided several implications regarding the further development and utilization of fidelity measures in universal behavioral supports.
Airway changes in patients with unilateral cleft lip/palate (UCL/P) after maxillary advancement
Authors: Idso Stefan , Holloway Jared , Patel Pravin , Zhao Linping , Forbes David , Liu Dawei
Published: June 2023

Objectives

To assess the effect on the retropalatal airway (RPA), retroglossal airway (RGA), and total airway (TA) volumes and cephalometrics (SNA, SNB, ANB, PP-SN, Occl-SN, N-A, A-TVL, B-TVL) after maxillary advancement orthognathic surgery in patients with unilateral cleft lip/palate (UCL/P) using cone-beam computed tomography (CBCT).

Materials and Methods

The CBCT scans of 30 patients (13 males and 17 females, 17–20 years old) with UCL/P were evaluated at two time points: preoperative (T1) and postoperative (T2). The interval between T1 and T2 ranged from 9–14 weeks, except for two patients in whom the interval was 24 weeks. Intraexaminer reliability was measured with an intraclass correlation coefficient test. A paired t-test was used to compare the airway and cephalometric measurements between T1 and T2, with a P value of .05 being considered significant.

Results

From T1 to T2, significant increases were found in the volumes of RPA (from 9574 ± 4573 to 10,472 ± 4767, P = .019), RGA (from 9736 ± 5314 to 11,358 ± 6588, P = .019), and TA (from 19,121 ± 8480 to 21,750 ± 10,078, P = .002). In addition, the RGA (from 385 ± 134 to 427 ± 165, P = .020) and TA (from 730 ± 213 to 772 ± 238, P = .016) sagittal area increased significantly. For minimal cross-sectional area (MCA), only the RPA increased significantly (from 173 ± 115 to 272 ± 129, P = .002). All cephalometric changes were statistically significant between T1 and T2 except for SNB.

Conclusions

Maxillary advancement in patients with UCL/P produces statistically significant increases in the retropalatal (volumetric and MCA), retroglossal (volumetric and sagittal), and total (volumetric and sagittal) airways based on data from CBCT imaging.
Brettspel som tilrettelegging for utdanning for berekraftige utvikling i barnehagen
Authors: Furnes Annette , Grindheim Liv Torunn
Published: June 2023

Det er aukande etterspurnad etter kunnskap om korleis ein kan leggje til rette for utdanning for berekraftig utvikling i barnehagen. Vi vil bidra med utvikling av leikande praksisar, avgrensa til deltaking i brettspel, sidan leiken er sett som barn sin måte å vere i verda og som ei transformativ kraft. Problemstillinga er: Kva innspel har barnehagelærarstudentar og barnehagelærarar til bruk av brettspel som utdanning for berekraftig utvikling i barnehagen? Materiale er henta frå to verkstadar; ein med studentar og ein med barnehagelærarar, og byggjer på eit fyrsteutkast av eit brettspel laga for vaksne. Observasjonar frå verkstadane og deltakarane sine forslag til korleis spelet kan utviklast for å vere relevant for barnehagebarn, er analysert ut frå ei teoretisk forståing av leikbasert utdanning for berekraftig utvikling. Analysen viser overlapping mellom økologiske, økonomiske, sosiale og kulturelle tilnærmingar til berekraft og berekraftig styresett, og dei leikande elementa er med i alle forslaga til brettspelet. Etter at form og innhald i spelet er vidareutvikla ut frå funna våre, vil vi prøve ut spelet saman med barn.
English abstract
Using board games to facilitate education for sustainable development in Early Childhood Education and Care (ECEC)
There is a growing need for knowledge on how to facilitate education for sustainable development in Early Childhood Education and Care (ECEC). Since play is considered children’s way of being in the world, and as a transformative force, we aim to investigate what should be taken into consideration when facilitating playing practices. In our study, the practices are manifested as a board game. The paper is organised around the research question: What suggestions do ECEC teacher students and teachers in ECEC institutions forward to develop a boardgame for education for sustainable development in ECEC? Material for analysis is based on two workshops: one with students and one with teachers and contains observations from the workshops and suggestions for how a boardgame for adults could be changed to be relevant for young children. The material is analysed based on theorised characteristics of play and education for sustainable development. The analysis reveals that the suggestions for revisions of the boardgame embrace play and reflect ecologic, economic, social, and cultural approaches to sustainability, together with sustainable governance. The form and content of the board game will be revised based on these results, and then be tested together with children.
Leder: Å skape bærekraftige barnehager – perspektiver, muligheter og utfordringer
Authors: Wergedahl Hege , Hu Aihua
Published: June 2023

Dette temanummeret har som hensikt å løfte frem mye av det barnehagesektoren har å bidra med når vi skal skape bærekraftige fremtider.
Influence of the Biofield Energy Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 in Male Sprague-Dawley Rats after a Single Oral Dose of Vitamin D3
Authors: Jana Snehasis
Published: June 2023

Vitamin D3 reported having many important roles in bone metabolism, osteoporosis, immunity, and useful in numerous diseases, i.e., cardiovascular, cancers, and neurodegenerative diseases. Unexpectedly, there is little information available about the concentration of 25-hydroxyvitamin D3 in the blood, which is the best indicator of vitamin D3 status after its oral absorption. However, the biological activity of vitamin D3 is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D3 . There are several factors that affect its absorption and first-pass metabolism that lead to having very low plasma concentrations of both the metabolites (25-hydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3 ) following an oral administration. Thus, the current study was executed to determine the influence of the Trivedi Effect®-Consciousness Energy Treatment on vitamin D3 and rats through the measurement of plasma 25-hydroxyvitamin D3 concentrations after the oral administration of vitamin D3 in male Sprague-Dawley rats. The test item, vitamin D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Treatment/Blessing), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Treatment by renowned Biofield Energy Healer, Dahryn Trivedi. Additionally, one group of animals also received Consciousness Energy Treatment per se by the Healer under similar conditions. The Biofield Energy Healer who was located in the USA, while the test samples and animals were located in the research laboratory in India. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated vitamin D3 ), G2 (Biofield Treated vitamin D3 ), and G3 (Biofield Treated animals received untreated vitamin D3 ) group. The Biofield Energy Treatment increased the maximum plasma concentration (Cmax) of 25-hydroxyvitamin D3 by 3.45% and 72.77% in the G2 and G3 groups, respectively as compared with the G1 group. The area under the plasma concentration– time curve (AUC0–t) of 25-hydroxyvitamin D3 was altered by -11.19% in the G2 group and 59.45% in the G3 group as compared to the G1 group. After oral administration, the Tmax of 25-hydroxyvitamin D3 was altered by -62.97% in G2 and 55.56% in G3 groups compared to G1. The mean residence time (MRT) of 25-hydroxyvitamin D3 was also altered in the G2 group by -12.34% and G3 group by 0.18%, as compared to the G1. The relative oral bioavailability (Fr) of 25-hydroxyvitamin D3 was significantly altered by -11.19% in the G2 group and 59.45% in the G3 group compared to the G1. Biofield Energy Treatment could be an innovative strategy that opens new avenues to overcome poorly absorbed pharmaceuticals/ nutraceuticals/herbal extracts and can also improve the therapeutic performance of orally active molecules.
Pathophysiology and Management of Bacterial Meningitis in Pediatrics
Authors: Bereda Gudisa
Published: June 2023

Bacterial meningitis in children and infants is correlated with substantial morbidity and mortality. Bacterial meningitis is one of the most frequent central nervous system infections, which is prevalent in low-income countries. There are three types of neonatal meningitis such as early-onset meningitis (from 0–6 days); late-onset meningitis (from 7–29 days) and extremely late-onset meningitis (from 30–90 days). The intense inflammation within the subarachnoid space noted in lumbar cerebrospinal fluid, and the resulting neurological damage, are not the direct result of the pathogenic bacteria but rather of activation of the host’s inflammatory pathways by the microorganisms or their products. All children who are suspected of having meningitis should have their cerebrospinal fluid examined unless lumbar puncture is contraindicated. The critical elements of managing pediatric meningitis involve prompt initiation of therapy, use of the appropriate antimicrobial with correct dosing and duration, attention to expected complications, and appropriate follow-up. In neonates, the primary empiric regimen used conventionally has been ampicillin and gentamycin. For infants whose cerebrospinal fluid is suspicious for bacterial meningitis, ampicillin (300 mg/kg per day divided every 6 hrs) and cefotaxime (200 to 300 mg/kg per day divided every 6 hrs) is appropriate.
Human Hair: An Important Biological Matrix of Interest
Authors: J Mbah Chika
Published: June 2023

Human hair can often be useful biological matrix, alternative to the conventional biological matrices such as blood, serum, urine, saliva etc for clinical and toxicological analyses. The objective of this article was to provide comprehensive details regarding the utilization of human hair as an analytical sample of interest. Such details involve presenting information on hair structure, mechanisms of active substances (drugs) incorporation into human hair, its merits as an analytical sample, collection and preparation for analysis, and various analytical techniques that have been used to determine active substances in the hair samples. The methodology used entailed obtaining information from published works in scientific journals, official books as well the internet websites. The results indicate that numerous active substances belonging to various pharmacological classes namely central nervous system analgesics, antidepressants, antipsychotics, anticonvulsants, anti-hypertensives, anti-inflammatory agents, anxiolytics, cannabinoides, sedatives and steroids etc. that have been incorporated into human hair by passive diffusion from the bloodstream into the growing hair cells or through sweat, sebum, and the external environment have been successfully determined. Literature has also revealed that the speed and extent of active substances penetrating black hair are related to the lipid solubility, molecular weight, and polarity of the active substances. In conclusion, the study has shown that human hair is an important biological matrix in clinical and toxicological analyses as well as in nutritional, archaeological and forensic investigations.
Rosa Damescana: A Review of its Conventional Uses Phytochemistry and Pharmacology
Authors: Asefa Kebede Isayas
Published: June 2023

In the past ten years, the use of herbal and ayurvedic medications has gained international attention due to their potential medicinal and financial benefits. The consistency, safety, and effectiveness of herbs have come under scrutiny due to their extensive use throughout the world. Rosa damascena is the flower’s king and a symbol of inspiration, beauty and it is a precious herb with contemporary pharmaceutical significance that is employed in medications. R. damascenes have chemical constituents like anthocyanins, terpenes, flavonoids, and glycosides. And also, Vitamins A, B3, C, D, and E are among the vitamins found in flowers. These herbs are used to produce the herbal remedy Gulkand, which is effective for constipation. Besides, depression mood, nervous tension, and stress are treated with it. The R. damascena has many pharmacological actions such as antibacterial activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus; antiviral activity against HSV-1, and Haemophilus parainfluenzae; anticancer activity; antidepressant activity; anticonvulsant effect; antioxidant effects; hepatoprotective activity and others. Thus, providing adequate logical support or evaluation for herbal health arguments has become the standard. This article examines traditional knowledge or claims, phytochemical and pharmacological justifications, as well as pharmacogenetic reasoning, and the plant’s prospective applications. Since ancient times, people have been taking advantage of the earth’s resources to discover novel phytoconstituents that can be used to cure a wide range of illnesses. Many of these treatments are still useful in today’s medicine. The search for potent natural and fresh semi-synthetic or copied compounds to treat human ailments is still ongoing, according to emerging data, and it is leading to the discovery of novel potent natural and fresh semi-synthetic or copied compounds.
Caves, the Mysterious World of Microorganisms
Authors: Elkhateeb Waill A
Published: June 2023

The unique structures of the remote caves, and the microorganism creatures living in this extreme dark environment should be investigated as an exceptional source for several new products and knowledge. Microorganisms obtained from such environment can be highly beneficial to science, health, and industry. Searching for novel isolates secreting potent secondary metabolites, and having promising biological activities is the target of current researches all over the world. In this review, it was highlighted that screening for microbes in remote areas especially remote caves following safety protocols will always result in isolation and identification and discovery of promising isolates with remarkable bioactivities. Many studies are required to complete investigating potentials of the promising isolated microorganisms.
Evaluation of Some Clinical Chemistry Parameters of Wistar Rats Induced with Staphylococcus aureus from Clinically Diagnosed Pneumonia Patients
Authors: Enwa Felix Oghenemaro
Published: June 2023

The effect and extent of changes in some clinical chemistry parameters associated with pneumonia caused by Staphylococcus aureus were investigated in serum samples of Wistar rats. A total of 1500 samples were collected randomly. The serum samples were tested for sodium, potassium, urea, creatinine and chloride by colorimetric methods. The concentrations of sodium ranged from 133.6±4.615 to 143.8±6.906, potassium values ranged from 5.78±1.26 to 8.02±0.779, urea gave a range of 10.143±0.69 to 14.444±2.404, chloride values ranged from 94.8±2.683 to 104.142±8.49, while creatinine values ranged from 0.489±0.033 to 1.7±2.404. The results indicated that staphylococcus aureus has a significant effect on the electrolyte balance causing hyperkalemia and decreased levels of sodium and chloride when compared with the normal range. It had a remarkable effect on creatinine level with only slight effect on urea. There is need to monitor the electrolyte levels in cases of staphylococcus aureus infection since alteration in the electrolyte levels could be harmful to health.
In Vitro and In Vivo Effectiveness of GPK/B2O, A Phytocomplex in Two Experimental Flu Virus Models
Authors: Fang He
Published: June 2023

There is constant quest to prevent and counterfight annual influenza viral epidemics, given the limitations and drawbacks of antivirals chemicals so far. The aim of the present study was to test on an experimental viral model a phytocompound containing herbal ingredients endowed by, albeit scattered, reports of antiviral properties (GPK/B20, Viraxil, Named, Italy). Two influenza models were employed, i.e. H1N1 and H3N2. In vitro test showed that GSK/B20, especially at medium and high dose (50µl/mL to 100µl/mL) significantly reduced the infection of Madin-Darby-Canine-Kidney monolayers cells and progression of cytopathogenic effect over the observation period. More interestingly, when this compound was test 1h after infection on mice, especially at high dose (60g/kg/day), it appeared to significantly blunt the immune/inflammatory cells recruitment and the inflammatory cytokine cascade (at lung tissue level and bronco-alveolar lavage level), curbing also the related gene expression. This was associated to a reduced lung oedema, which is the correlate of respiratory distress in humans, viral load and scanning electron microscopy findings. In the meantime, more detailed experimental studies are warranted to unveil the range of mechanisms of actions that these natural ingredients are likely to be endowed with. Although these data have to be taken with caution having being obtained in an experimental-controlled setting, they suggest a potential safe application in the clinical practice, as recently corroborated for one of the herbal used.
Covid Cure in the Light of Diet: Eating Habits
Authors: Murti Yogesh
Published: June 2023

People those who eat nutritious and a well-balanced diet will possess a strong immune systems along with low incidence of chronic and infectious diseases. People with chronic disease would have the possibility to get infect with COVID-19; thereby they may require supportive help in relation to balance their mental health and even diet which can ensure to improve their health. Some vitamins and foods should be included in our diet to provide strong and improved immune system that can able to fight against COVID-19. The spread of misinformation is a dangerous thing at all times. There are a plethora of questions that arise in the realm of food and eating practices in this pandemic time. This chapter will help you to choose your diet either you are vegetarian and non-vegetarian.
Antifungal Drugs Loaded Nanosponges to Improve Bioavailability of Antifungal Drugs; A Review
Authors: Shahzad Qasim
Published: June 2023

Fungal infections have become a major concern in this era for human health leading to morbidity and mortality. A lot of antifungal agents are available for treatment, with poor therapeutic outcomes due to poor bioavailability, toxicity, and resistance challenges. Ordinary dosage forms are unable to meet the clinical needs. Nanosponges provide a promising drug delivery system overcoming major challenges concerned with antifungal agents. Nanosponges improves solubility, permeation, taste masking and stability of antifungal agents. It serves as an important tool for providing controlled release dosage forms. The nanosponges are easier to formulate and convenient for bilk manufacturing. Nanosponges thus provide various benefits to clinician to cope the overcoming demand of fungal infectious disease.
Facile Synthesis of Copper Sulphide Nanoparticles using Trichoderma Harzianum and Antibacterial Efficiency Enhancement by Gentamicin Sulfate
Authors: K Byrappa
Published: June 2023

The application of biosynthesized semiconductor nanomaterials has gained recent attention towards pathogenic bacteria. This study reports cost- effective, eco- friendly biosynthesis of copper sulphide nanoparticles (CuS NPs) employing the fungal cell mass of the biocontrol pest, T. harzianum. Later, gentamicin was loaded onto the mycosynthesised CuS NPs to assess the enhancement in its antibacterial activity. A synergistic antibacterial efficacy was observed for the GS- laden CuS NPs against the pathogens tested (E. coli, Salmonella Typhi, Klebsiella pneumoniae, Staphylococcus aureus and Bacillus subtilis). The green synthesized CuS NPs as well as GS- laden CuS NPs were found to be relatively non- toxic towards MDA MB- 231 epithelial cell line. In short, the GS- laden CuS NPs were found to be an effective candidate to combat pathogenic microorganisms. The present study highlights the facile synthesis of semiconductor nanomaterials which could act as potential drug carrier and opens the feasibility of biocompatible materials for drug loading in the field of nanomedicine.
Marine Environment, the Secretive World of Endophytic Microorganisms
Authors: WA Elkhateeb
Published: June 2023

Marine, endophytic microorganism creatures living in this environment should be investigated as an exceptional source for several new products and knowledge. Microorganisms obtained from such environment can be highly beneficial to science, health, and industry. Searching for novel isolates secreting potent secondary metabolites, and having promising biological activities is the target of current researches all over the world. In this review, it was highlighted that screening for endophytic fungi from marine sources with remarkable bioactivities. Many studies are required to complete investigating potentials of the promising isolated endophytic microorganisms.
Pharmacological Action of Taxifolin: A Review
Authors: Mahmood Mohd Ameen
Published: June 2023

Taxifolin is a potent plant flavonoid. The most sources of taxifolin include onions, tamarind seeds, French maritime bark and milk thistle and are also commercially available in semisynthetic forms. It was within the mid-1950s that scientists for the first time extracted and respected taxifolin, (dihydroquercetin) which is an analogue of quercetin or rutin but with somewhat different properties. It displays vitamin P activities, boosting vascular membranes and inflammatory reactions, reducing allergic and also has many properties not shared by the majority of other bioflavonoids. Taxifolin therefore exerts a much more potent antioxidant action than most flavonoids. The main pharmacological actions of taxifolin are antibacterial, antioxidative, antifungal, anticancer and even anti-inflammatory actions. Hence, an attempt was taken to review the therapeutics actions of taxifolin.
Study protocol: Generation Victoria (GenV) special care nursery registry
Authors: Wang Jing , Hu Yanhong , Collins Lana , Fedyukova Anna , Aggarwal Varnika , Mensah Fiona , Cheong Jeanie , Wake Melissa , None
Published: June 2023

IntroductionNewborn babies who require admission for specialist care can experience immediate and sometimes lasting impacts. For babies admitted to special care nurseries (SCN), there is no dataset comparable to that of the Australian and New Zealand Neonatal Network (ANZNN), which has helped improve the quality and consistency of neonatal intensive care through standardised data collection.
ObjectivesWe aim to establish a proof-of-concept, Victoria-wide registry of babies admitted to SCN, embedded within the whole-of-Victoria Generation Victoria (GenV) cohort.
MethodsThis prototype registry is a depth sub-cohort nested within GenV, targeting all babies born in Victoria from Oct-2021 to Oct-2023. Infants admitted to SCN are eligible. The minimum dataset will be harmonised with ANZNN for common constructs but also include SCN-only items, and will cover maternal, antenatal, newborn, respiratory/respiratory support, cardiac, infection, nutrition, feeding, cerebral and other items. As well as the dataset, this protocol outlines the anticipated cohort, timeline for this registry, and how this will serve as a resource for longitudinal research through its integration with the GenV longitudinal cohort and linked datasets.
ConclusionThe registry will provide the opportunity to better understand the health and future outcomes of the large and growing cohort of children that require specialist care after birth. The data would generate translatable evidence and could lay the groundwork for a stand-alone ongoing clinical quality registry post-GenV.