bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: [RhIII(Cp*)]‐Catalyzed Cascade Arylation and Chlorination of α‐Diazocarbonyl Compounds with Arylboronic Acids and N‐Chlorosuccinimide for Facile Synthesis of α‐Aryl‐α‐chloro Carbonyl Compounds.
Authors: Ng Fo‐Ning , Lau Yan‐Fung , Zhou Zhongyuan , Yu Wing‐Yiu
Published: July 2015

A straightforward route to a diverse range of α‐aryl‐α‐chloro carbonyl compounds is developed.
ChemInform Abstract: Catalytic Domino Reaction of Ketones/Aldehydes with Me3SiCF2Br for the Synthesis of α‐Fluoroenones/α‐Fluoroenals.
Authors: Song Xiaoning , Chang Jian , Zhu Dongsheng , Li Jiaheng , Xu Cong , Liu Qun , Wang Mang
Published: July 2015

The method is applicable to a range of aryl ketones including steroid derivatives.
ChemInform Abstract: Copper(I)‐Catalyzed Dehydrogenative Amidation of Arenes Using Air as the Oxidant.
Authors: Li Gang , Jia Chunqi , Chen Qingliang , Sun Kai , Zhao Feng , Wu Hankui , Wang Zhiyong , Lv Yunhe , Chen Xiaolan
Published: July 2015

The intermolecular dehydrogenative amidation of various arenes via C—H bond activation assisted by a 2‐pyridyl or 1‐pyrazolyl chelating group using air as the terminal oxidant is achieved using N‐aryl amides, N‐alkyl amides, benzamide derivative, imides, and lactams as coupling partners.
ChemInform Abstract: Pyrrolidine Catalyzed Reactions of Cyclopentadiene with α,β‐Unsaturated Carbonyl Compounds: 1,2‐ versus 1,4‐Additions.
Authors: Coskun Necdet , Cetin Meliha , Gronert Scott , Ma Jingxiang , Erden Ihsan
Published: July 2015

The pyrrolidine‐catalyzed reactions of benzalacetones (I) with cyclopentadiene leads to isolable intermediate Michael adducts (III) and (IV), which are converted into 1,2‐dihydropentalenes (V) at longer reaction times.
ChemInform Abstract: Palladium‐Catalyzed Allylic Substitution of Secondary Allylic Esters with Ketone Enolates.
Authors: Kinouchi Wataru , Saeki Ryohei , Kawashima Hidehisa , Kobayashi Yuichi
Published: July 2015

The Pd‐catalyzed allylic substitution of phosphate esters with lithium enolates proceeds regioselectively.
ChemInform Abstract: Ruthenium‐Catalyzed Heteroatom‐Directed Regioselective C—H Arylation of Indoles Using a Removable Tether.
Authors: Tiwari Virendra Kumar , Kamal Neha , Kapur Manmohan
Published: July 2015

A novel method for the regioselective Ru‐catalyzed C—H arylation of indoles at the C‐2 position is developed using a 2‐pyridyl substituent as directing group, which can easily be removed.
ChemInform Abstract: Direct ortho‐C—H Functionalization of Aromatic Alcohols Masked by Acetone Oxime Ether via exo‐Palladacycle.
Authors: Guo Kun , Chen Xiaolan , Guan Mingyu , Zhao Yingsheng
Published: July 2015

An oxime ether directing group for the Pd‐catalyzed selective ortho‐olefination of aromatic alcohols is developed.
ChemInform Abstract: Synthesis and Catalytic Activity of a Grubbs‐Hoveyda Pre‐Catalyst Having a Trimeric Resting State.
Authors: Liu Guiyan , Wu Bin , Wang Jianhui
Published: July 2015

The new Grubbs‐Hoveyda pre‐catalyst shows high activity for the ring‐closing‐metathesis of a wide range of olefinic substrates.
ChemInform Abstract: Rh(III)‐Catalyzed Decarboxylative ortho‐Heteroarylation of Aromatic Carboxylic Acids by Using the Carboxylic Acid as a Traceless Directing Group.
Authors: Qin Xurong , Sun Denan , You Qiulin , Cheng Yangyang , Lan Jingbo , You Jingsong
Published: July 2015

The highly regioselective title reaction with various heteroarenes (e.g., thiophenes, furans, indoles, indolizines, azoles, and xanthines) uses the carboxylic acid as a traceless directing group.
ChemInform Abstract: Ammonium Nitrate: A Biodegradable and Efficient Catalyst for the Direct Amidation of Esters under Solvent‐Free Conditions.
Authors: Ramesh Perla , Fadnavis Nitin W.
Published: July 2015

A simple, metal‐free, and environment‐friendly procedure for amidation of esters with amines using ammonium nitrate as catalyst is developed.
ChemInform Abstract: Gold‐Catalyzed, SN1‐Type Reaction of Alcohols to Afford Ethers and Cbz‐Protected Amines.
Authors: Vinson Andrew R. S. , Davis Victoria K. , Arunasalam Arunamarie , Jesse Kate A. , Hamilton Rachael E. , Shattuck Morgan A. , Hu Allison C. , Iafe Robert G. , Wenzel Anna G.
Published: July 2015

Unsymmetrical ethers and Cbz‐protected amines are directly obtained by a gold‐catalyzed and microwave‐assisted method to activate alcohols through an intermolecular SN1 type reaction.
ChemInform Abstract: Chemoselective Formation of Unsymmetrically Substituted Ethers from Catalytic Reductive Coupling of Aldehydes and Ketones with Alcohols in Aqueous Solution.
Authors: Kalutharage Nishantha , Yi Chae S.
Published: July 2015

A convenient protocol including a ruthenium hydride catalyst for the reductive etherification reaction of carbonyl compounds with alcohols to give unsymmetrical ethers is presented.
ChemInform Abstract: Water‐Mediated Three‐Component Wittig—SNAr Reactions.
Authors: Xu Zian , Zhai Wanwan , Feng Congpeng , Liu Hongwei , Zhao Jianhong , Yu Xinhong
Published: July 2015

A green facile one‐pot, three‐component Wittig—SN method for the synthesis of (E)‐3‐[4‐(cycloamino‐1‐yl)‐3‐nitro/cyanophenyl]acrylates and their analogues starting from nitro or cyano group activated haloaromatic aldehydes, secondary amines, and quaternary phosphonium salts with high E‐selectivity is developed using water as simple, non‐toxic, convenient, and environmentally benign solvent.
ChemInform Abstract: Asymmetric Robinson‐Type Annulation Reaction Between β‐Ketoamides and α,β‐Unsaturated Ketones.
Authors: Huang You‐ming , Zheng Chang‐wu , Zhao Gang
Published: July 2015

Enantioselective Robinson‐type annulation reaction between β‐ketoamide and α,β‐unsaturated ketone is developed by utilizing the amino acid derived diamine catalysts.
ChemInform Abstract: One‐Pot Synthesis of Aliphatic Nitro Compounds by Michael/Retro‐Claisen Fragmentation Domino Reaction.
Authors: Zhang Wei , Wang Yanjing , Bai Cuibing , Wen Jialong , Wang Naixing
Published: July 2015

A novel and concise method for the synthesis of γ‐nitro ketones and 1,3‐dinitro compounds from 2‐nitrovinylphenols (I) involving a chemoselective acyltransfer is developed.
ChemInform Abstract: Indium Triflate in 1‐Isobutyl‐3‐methylimidazolium Dihydrogen Phosphate (IOL): An Efficient and Green Catalytic System for Friedel—Crafts Acylation.
Authors: Tran Phuong Hoang , Hansen Poul Erik , Hoang Huy Manh , Chau Duy‐Khiem Nguyen , Le Thach Ngoc
Published: July 2015

The novel ionic liquid is employed as solvent in the In(OTf)3‐catalyzed Friedel—Crafts acylation of electron rich arenes with anhydrides.
ChemInform Abstract: Palladium on Carbon‐Catalyzed Aqueous Transformation of Primary Alcohols to Carboxylic Acids Based on Dehydrogenation under Mildly Reduced Pressure.
Authors: Sawama Yoshinari , Morita Kosuke , Asai Shota , Kozawa Masami , Tadokoro Shinsuke , Nakajima Junichi , Monguchi Yasunari , Sajiki Hironao
Published: July 2015

The clean and first dehydrogenation of primary alcohols to carboxylic acids in presence of a heterogeneous catalyst is presented.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Oxidative Amidation of Aldehydes with Amines.
Authors: Alanthadka Anitha , Maheswari C. Uma
Published: July 2015

The oxidative amidation of aromatic aldehydes in presence of NBS as oxidant furnishes the products in good yields.
ChemInform Abstract: Novel SF5‐Anilines and SF5‐Aryl Ethers from SF5‐Substituted Potassium Aryl Trifluoroborates.
Authors: Joliton Adrien , Carreira Erick M.
Published: July 2015

3‐SF5‐aryl ether (IX) and (X) are obtained by Chan—Lam—Evans coupling reaction of phenols and alkyl alcohols with SF5‐substituted potassium aryltrifluoroborates.
ChemInform Abstract: PhI(OAc)2 Mediated Decarboxylative Sulfonylation of β‐Aryl‐α,β‐unsaturated Carboxylic Acids: A Synthesis of (E)‐Vinyl Sulfones.
Authors: Katrun Praewpan , Hlekhlai Sornsiri , Meesin Jatuporn , Pohmakotr Manat , Reutrakul Vichai , Jaipetch Thaworn , Soorukram Darunee , Kuhakarn Chutima
Published: July 2015

Under the optimized reaction conditions a wide range of functionalities both in the unsaturated carboxylic acids as well as the sodium sulfonates are tolerated.
ChemInform Abstract: Copper‐Catalyzed Oxidative Alkenylation of C(sp3)—H Bonds via Benzyl or Alkyl Radical Addition to β‐Nitrostyrenes.
Authors: Guo Shengrong , Yuan Yanqin , Xiang Jiannan
Published: July 2015

A novel approach to (E)‐β‐alkylstyrenes is introduced by using di‐tert‐butyl peroxide as oxidant.
ChemInform Abstract: Hypervalent Iodine(III)‐Mediated Benzannulation of Enamines with Alkynes: An Efficient Synthesis of Substituted Aminonaphthoic Acid Derivatives.
Authors: Gao Peng , Fan Mingjin , Bai Zijing , Wei Yunyang
Published: July 2015

When meta‐substituted phenyl enamines (I), (VIII) are employed in the reaction, two cyclization paths are detected and ortho‐cyclization products are obtained as the only or major products.
ChemInform Abstract: Substituent‐Controlled Annuloselectivity and Stereoselectivity in the Sulfa‐Staudinger Cycloadditions.
Authors: Yang Zhanhui , Chen Ning , Xu Jiaxi
Published: July 2015

Depending on the N‐substituent, the title reaction between imines and ethyl 2‐chlorosulfonylacetate (II) gives either trans‐β‐sultams or a mixture of corresponding trans‐β‐sultams and 1,2,4‐thiadiazinane 1,1‐dioxides.
ChemInform Abstract: Thiophene Synthesis via 1,1‐Carboboration.
Authors: Eller Christina , Kehr Gerald , Daniliuc Constantin G. , Stephan Douglas W. , Erker Gerhard
Published: July 2015

Bis(tert‐butylethynyl) sulfide reacts with boronic Lewis acids to give borylated thiophenes via sequential 1,1‐carboboration reactions.
ChemInform Abstract: Tandem Thien‐ and Benzannulations of α‐Alkenoyl‐α‐Alkynyl Ketene Dithioacetals with Cyanoacetates: Synthesis of Functionalized Benzo[b]thiophenes.
Authors: Ming Wenbo , Liu Xiaocui , Wang Lianjie , Liu Jun , Wang Mang
Published: July 2015

A novel domino annulation strategy for the construction of benzo[b]thiophenes is presented which occurs in the presence of Cs2CO3 and Ag2CO3.
ChemInform Abstract: Efficient Synthesis of Highly Enantioenriched Δ1‐Pyrrolines.
Authors: Resende Diana I. S. P. , Guieu Samuel , Oliva Cristina G. , Silva Artur M. S.
Published: July 2015

The title compounds are efficiently obtained by a one‐pot nitro‐reduction, cyclization, and dehydration sequence from (R,E)‐1,5‐diaryl‐3‐(nitromethyl)‐5‐pent‐4‐en‐1‐ones.
ChemInform Abstract: meso‐Hydroxysubporphyrins: A Cyclic Trimeric Assembly and a Stable meso‐Oxy Radical.
Authors: Shimizu Daiki , Oh Juwon , Furukawa Ko , Kim Dongho , Osuka Atsuhiro
Published: July 2015

synthesis and characterization
ChemInform Abstract: Synthesis of 2‐Acylated Indoles Through Palladium‐Catalyzed Dehydrogenative Coupling of N‐Pyrimidine‐Protected Indoles with Aldehydes and Ethyl Glyoxylate.
Authors: Wang Wenduo , Liu Jidan , Gui Qingwen , Tan Ze
Published: July 2015

A wide range of 2‐acylated indoles are obtained using tBuOOH as oxidant.
ChemInform Abstract: Efficient Synthesis of Some New Antiproliferative N‐Fused Indoles and Isoquinolines via 1,3‐Dipolar Cycloaddition Reaction in an Ionic Liquid.
Authors: Sutariya Tushar R. , Labana Balvantsingh M. , Parmar Narsidas J. , Kant Rajni , Gupta Vivek K. , Plata Gabriela B. , Padron Jose M.
Published: July 2015

New and bioactive compounds are synthesized using triethylammonium acetate as inexpensive, recyclable, and environmentally friendly ionic liquid.
ChemInform Abstract: Ligand‐free Heck—Mizoroki Reaction for 1,3,5‐Trisubstituted Pyrazoles.
Authors: Sera Misayo , Mizufune Hideya , Tawada Hiroyuki
Published: July 2015

The Heck—Mizoroki reaction of 5‐trifluoromethanesulfonates of pyrazoles (I) with acrylic ester derivatives (II) is reported.
ChemInform Abstract: Zincation of 4,4‐Dimethyloxazoline Using TMPZnCl·LiCl. A New Preparation of 2‐Aryloxazolines.
Authors: Haas Diana , Hofmayer Maximilian S. , Bresser Tomke , Knochel Paul
Published: July 2015

A simple, mild and efficient method for the zincation of 4,4‐dimethyloxazoline in position 2 using TMPZnCl·LiCl is reported.
ChemInform Abstract: Gold‐Catalyzed Cycloaddition Reactions of Ethyl Diazoacetate, Nitrosoarenes, and Vinyldiazo Carbonyl Compounds: Synthesis of Isoxazolidine and Benzo[b]azepine Derivatives.
Authors: Pagar Vinayak Vishnu , Liu Rai‐Shung
Published: July 2015

A gold‐catalyzed three‐component reaction of vinyldiazo carbonyl compounds, nitrosobenzenes, and ethyl diazoacetate is developed to give diazo‐containing isoxazolines in high diastereoselectivities.
ChemInform Abstract: Direct Synthesis of 2‐Arylbenzothiazoles from Benzothiazoles with Phenylglycine Derivatives Mediated by Cu(OTf)2/K2S2O8.
Authors: Wang Rui , An Chun‐hong , Li Yang , Zhao Yue , Wang Tao , Li Ao
Published: July 2015

The reaction tolerates various functional groups in both partners and affords 2‐arylbenzothiazoles in moderate to good yields.
ChemInform Abstract: Multicomponent Syntheses to Alkene‐ and Alkyne‐Functionalized Benzopyrans via Alkynylation and [4 + 2] Cyclization in One‐Pot Process.
Authors: Shao Jidong , Li Liqi , Zhang Jie , Tian Tian , Xue Jijun , Zhang Yuan , Li Ying
Published: July 2015

A wide range of 2‐alkenyl‐4‐alkynyl benzopyrans are efficiently obtained with good diastereoselectivity.
ChemInform Abstract: Palladium‐Catalyzed Difunctionalization of Internal Alkynes via Highly Regioselective 6‐endo Cyclization and Alkenylation of Enynoates: Synthesis of Multisubstituted Pyrones.
Authors: Tian Pan‐Pan , Cai Sai‐Hu , Liang Qiu‐Ju , Zhou Xing‐Yi , Xu Yun‐He , Loh Teck‐Peng
Published: July 2015

The efficient one‐pot method provides various multisubstituted pyrones equipped with a diverse range of functional groups in moderate to high yields.
ChemInform Abstract: Palladium‐Catalyzed One‐Pot Sonogashira Coupling, exo‐dig Cyclization and HydrideTransfer Reaction: Synthesis of Pyridine‐Substituted Pyrroles.
Authors: Shekarrao Kommuri , Kaishap Partha Pratim , Gogoi Sanjib , Boruah Romesh C.
Published: July 2015

The one‐pot, three‐component protocol furnishes alkylated pyridine‐substituted pyrroles from the reaction of bromovinylaldehydes, primary amines, and 2‐alkynylpyridines.
ChemInform Abstract: Rhodium‐Catalyzed Decarbonylative Direct Olefination of Arenes with Vinyl Carboxylic Acids.
Authors: Qiu Ruiying , Zhang Lingjuan , Xu Conghui , Pan Yixiao , Pang Hongze , Xu Lijin , Li Huanrong
Published: July 2015

A direct olefination of pyridyl‐substituted arenes with readily available vinylcarboxylic acids without external oxidant is presented.
ChemInform Abstract: Iridium‐Catalyzed Selective Hydrogenation of 3‐Hydroxypyridinium Salts: A Facile Synthesis of Piperidin‐3‐ones.
Authors: Huang Wen‐Xue , Wu Bo , Gao Xiang , Chen Mu‐Wang , Wang Baomin , Zhou Yong‐Gui
Published: July 2015

The scalable reaction procedure allows for the preparation of a variety of aryl and alkyl substituted 2‐ and 4‐piperidin‐3‐ones.
ChemInform Abstract: Chiral Pyrrolidines and Piperidines from Enantioselective Rhodium‐Catalyzed Cascade Arylative Cyclization.
Authors: Serpier Fabien , Flamme Benjamin , Brayer Jean‐Louis , Folleas Benoit , Darses Sylvain
Published: July 2015

Starting from nitrogen‐tethered alkynoates and various aryl boronic acids chiral pyrrolidines and piperidines are prepared in moderate to high yields and with high enantioselectivity.
ChemInform Abstract: Two‐Step Solid‐State Synthesis of PEPPSI‐Type Compounds.
Authors: Adams Christopher J. , Lusi Matteo , Mutambi Emily M. , Orpen A. Gay
Published: July 2015

The two‐step mechanochemical preparation of carbene—pyridine complexes of palladium and platinum is reported.
ChemInform Abstract: Synthesis of 4‐Quinolones, Benzopyran Derivatives and Other Fused Systems Based on the Domino ANRORC Reactions of (ortho‐Fluoro)‐3‐benzoylchromones.
Authors: Iaroshenko Viktor O. , Mkrtchyan Satenik , Gevorgyan Ashot , Grigoryan Tatevik , Villinger Alexander , Langer Peter
Published: July 2015

The strategy is based on a scalable transition metal‐free one‐pot domino reaction with a broad substrate scope.
ChemInform Abstract: Monofluoromethylation of Tetrahydroisoquinolines by Visible‐Light Induced Direct C(sp3)—H Bond Activation.
Authors: Li Weipeng , Zhu Yunhuang , Duan Yingqian , Zhang Muliang , Zhu Chengjian
Published: July 2015

C‐1‐monofluoromethylated tetrahydroisoquinolines are obtained by visible‐light photoredox‐catalyzed reaction of tetrahydroisoquinolines with β‐fluorinated gem‐diols as CF‐source under mild reaction conditions.
ChemInform Abstract: A Convenient Synthesis of Indoloquinolinones via 3‐Arylation of Indole‐2‐carboxamides and PIDA‐Mediated C—N Bond Formation.
Authors: Li Yulin , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang
Published: July 2015

Biologically important indoloquinolinone derivatives are prepared via a two step procedure.
ChemInform Abstract: Copper‐Catalyzed Aerobic Cascade Reaction for the Conversion of 3,4‐Dihydropyrimidine‐2(1H)‐thiones to Arylthiopyrimidines.
Authors: Lee Ok Suk , Lee HyunKyung , Kim Hyejee , Shin Hyunik , Sohn Jeong‐Hun
Published: July 2015

35 examples
ChemInform Abstract: Chemo‐Controlled Cross‐Coupling of Di(hetero)aryl Disulfides with Grignard Reagents: C—C vs.C—S Bond Formation.
Authors: Du Bao‐Xin , Quan Zheng‐Jun , Da Yu‐Xia , Zhang Zhang , Wang Xi‐Cun
Published: July 2015

The protocol for the chemoselective coupling reaction affords either a C—S bond in presence of ferrocene catalyst or the formation of a C—C bond in presence of palladium acetate catalyst.
ChemInform Abstract: Efficient Synthesis of (Arylethynyl)pyrrolo[2,3‐d]pyrimidines by Stille Coupling.
Authors: Bucevicius Jonas , Tumkevicius Sigitas
Published: July 2015

A wide range of new pyrrolo[2,3‐d]pyrimidine derivatives, including those with different arylethynyl groups in position C‐2 and C‐4 of the heterocycle, are obtained by palladium‐catalyzed cross‐coupling reaction of 2,4‐dichloro‐7‐methylpyrrolo[2,3‐d]pyrimidine (I) with (arylethynyl)tributylstannanes.
ChemInform Abstract: Ligand‐Free Pd‐Catalyzed and Copper‐Assisted C—H Arylation of Quinazolin‐4‐ones with Aryl Iodides under Microwave Heating.
Authors: Laclef Sylvain , Harari Marine , Godeau Julien , Schmitz‐Afonso Isabelle , Bischoff Laurent , Hoarau Christophe , Levacher Vincent , Fruit Corinne , Besson Thierry
Published: July 2015

Several quinazolin‐4‐ones and pyrido‐pyrimidin‐4‐one derivatives thereof are transformed according to the title reaction.
ChemInform Abstract: Expeditious Synthesis of (.+‐.)‐Diethyl 2‐Alkyl‐ and 2‐Aryl‐(3‐oxoisoindolin‐1‐yl)phosphonates Catalyzed by OSU‐6.
Authors: Muddala Nagendra Prasad , Nammalwar Baskar , Bunce Richard A.
Published: July 2015

Starting from 2‐carboxybenzaldehyde, triethyl phosphite and aryl, benzyl, or alkyl amines an efficient preparation of the title products is performed.
ChemInform Abstract: Versatile Synthesis of Phospholides from Open‐Chain Precursors. Application to Anellated Pyrrole— and Silole—Phosphole Rings.
Authors: Xu Youzhi , Wang Zhihua , Gan Zhenjie , Xi Qiuzhen , Duan Zheng , Mathey Francois
Published: July 2015

The first general synthesis of phospholides and annelated phospholides starting from open‐chain precursors is presented.
ChemInform Abstract: Synthesis of Chalcogenophenes via Cyclization of 1,3‐Diynes Promoted by Iron(III) Chloride and Dialkyl Dichalcogenides.
Authors: Bilheri Filipe N. , Stein Andre L. , Zeni Gilson
Published: July 2015

The dibutyl diselenide‐mediated reaction furnishes symmetrical and unsymmetrical selenophenes under mild conditions.
ChemInform Abstract: Stereodivergent Hydrogermylations of α‐Trifluoromethylated Alkynes and Their Applications in Cross‐Coupling Reactions.
Authors: Schweizer Stephane , Tresse Cedric , Bisseret Philippe , Lalevee Jacques , Evano Gwilherm , Blanchard Nicolas
Published: July 2015

(Z)‐ and (E)‐α‐CF3‐vinylgermanes are regio‐ and stereoselectively prepared under radical or Pd‐catalyzed conditions.
ChemInform Abstract: Prenylated Indole Alkaloids from the Marine‐Derived Fungus Paecilomyces variotii.
Authors: Zhang Peng , Li Xiao‐Ming , Wang Jia‐Ning , Li Xin , Wang Bin‐Gui
Published: July 2015

Evaluation of the cytotoxic activity of the newly isolated indole alkaloids, dihydrocarneamide A (I) and iso‐notoamide (II), reveals a weak cytotoxicity.
ChemInform Abstract: Isoprenylated Flavones from Garcinia bracteata and Their anti‐Tobacco Mosaic Virus Activity
Authors: Hu Qiufen , Ning Ping , Li Limei , Lou Jie , Cheng Yang , Shi Lei , Shu Duntao , Gao Xue‐Mei , Yang Yuehong , Wang Yede
Published: July 2015

isolation and structure elucidation of two new isoprenylated flavones, bracteflavone A (I) and B (II), along with four known flavones with potential anti‐TMV activity
ChemInform Abstract: Growth of GaN Layers on Sapphire by Low‐Temperature‐Deposited Buffer Layers and Realization of p‐Type GaN by Magesium Doping and Electron Beam Irradiation (Nobel Lecture)
Authors: Amano Hiroshi
Published: July 2015

Review: personal account of the background of the studies that led to the technologies for growing GaN and producing p‐GaN; 61 refs.
ChemInform Abstract: Preparation and Catalytic Applications of Nanomaterials: A Review
Authors: Sharma Navneet , Ojha Himanshu , Bharadwaj Ambika , Pathak Dharam Pal , Sharma Rakesh Kumar
Published: July 2015

Review: 299 refs.
ChemInform Abstract: Metal Oxides and Metal Salt Nanostructures for Hydrogen Sulfide Sensing: Mechanism and Sensing Performance
Authors: Guo Zhi , Chen Guiqiu , Zeng Guangming , Liu Lingzhi , Zhang Chang
Published: July 2015

Review: 122 refs.
ChemInform Abstract: Lithium Vanadium Phosphate as Cathode Material for Lithium Ion Batteries
Authors: Tao Du , Wang Shengping , Liu Yongchao , Dai Yu , Yu Jingxian , Lei Xinrong
Published: July 2015

Review: 218 refs.
ChemInform Abstract: Hemithioindigo — An Emerging Photoswitch
Authors: Wiedbrauk Sandra , Dube Henry
Published: July 2015

Review: [67 refs.
ChemInform Abstract: Recent Applications of Magnetically Recoverable Nanocatalysts in C—C and C—X Coupling Reactions
Authors: Karimi Babak , Mansouri Fariborz , Mirzaei Hamid M.
Published: July 2015

Review: [199 refs.
ChemInform Abstract: Merging Visible‐Light‐Photoredox and Nickel Catalysis
Authors: Vila Carlos
Published: July 2015

Review: [scope and limitations of the combination of nickel and photoredox catalysis for Csp3—Csp2 cross‐coupling reactions; 18 refs.
ChemInform Abstract: Synthesis of Five‐Membered N,N,N‐ and N,N,N,N‐Heterocyclic Compounds: Applications of Microwaves
Authors: Kaur Navjeet
Published: July 2015

Review: 111 refs.
ChemInform Abstract: An Update on New Methods to Synthesize Cyclotetrapeptides
Authors: De Leon Rodriguez Luis M. , Weidkamp Andreas J. , Brimble Margaret A.
Published: July 2015

Review: 83 refs.
ChemInform Abstract: Functional Precision Polymers via ADMET Polymerization
Authors: Bachler Patricia R. , Wagener Kenneth B.
Published: July 2015

Review: 62 refs.
ChemInform Abstract: The Radical‐Chain Addition to Double Molecular Bonds by the Nonbranched‐Chain Mechanism: Low‐Reactive Free Radicals Shortening Kinetic Chains
Authors: Silaev Michael M.
Published: July 2015

Review: 117 refs.
ChemInform Abstract: Diverse Reactions of α/β‐Mercaptoalkanoic Acids: In the Syntheses of Condensed Fused Polycyclic Heterocycles
Authors: Batchu Chandrasekhar
Published: July 2015

Review: 172 refs.
ChemInform Abstract: Synthesis of Seven‐Membered Ring Ethers and Lactones
Authors: Piva Olivier
Published: July 2015

Review: 103 refs.
ChemInform Abstract: Digging into the Mechanism of Oxidative Pd(II)‐Catalyzed Aminations
Authors: Lorion Melanie M. , Nahra Fady , Ly Vu Linh , Mealli Carlo , Messaoudi Abdelatif , Uron Frederic , Oble Julie , Pou Giovanni
Published: July 2015

Review: 49 refs.
ChemInform Abstract: Mechanisms of Glycosylation Reactions Studied by Low‐Temperature Nuclear Magnetic Resonance
Authors: Frihed Tobias Gylling , Bols Mikael , Pedersen Christian Marcus
Published: July 2015

Review: 235 refs.
ChemInform Abstract: Suitable Multicomponent Organic Synthesis Using Heteropolycompounds as Catalysts
Authors: Sanchez Laura M. , Thomas Horacio J. , Romanelli Gustavo P.
Published: July 2015

Review: 105 refs.
ChemInform Abstract: Cellular Uptake: Lessons from Supramolecular Organic Chemistry
Authors: Gasparini Giulio , Bang Eun‐Kyoung , Montenegro Javier , Matile Stefan
Published: July 2015

Review: 78 refs.+ subrefs.
ChemInform Abstract: Research Progress on Methane Production from Natural Gas Hydrates
Authors: Xu Chun‐Gang , Li Xiao‐Sen
Published: July 2015

Review: characteristics of gas hydrate reservoirs, production methods, numerical simulations and field production tests; 296 refs.
Self‐Assembly of Organic Building Blocks with Directly Exfoliated Graphene to Fabricate Di‐ and Tricomponent Hybrids
Authors: Xing Pengyao , Bai Linyi , Chen Hongzhong , Tham Phoebe Huijun , Hao Aiyou , Zhao Yanli
Published: July 2015

In this work, we developed a strategy to fabricate self‐assembled aggregates encapsulating graphene from direct exfoliation of graphite. Naphthalene‐anhydride‐appended glutamic acid (NG) and pyrene‐appended glutamic acid (PG) were utilized to exfoliate graphite to generate few‐layer graphene in basic aqueous media. Acidification‐triggered self‐assembly of PG could encapsulate graphene sheets to give graphene@microsheet hybrids. Melamine (Mm) was introduced to induce the morphological transformation of PG from microsheets to twisted fibers with columnar packing. In the presence of graphene, this transformation allowed the fabrication of twisted‐fiber‐encapsulated graphene (graphene@twist fiber). Tricomponent hybrids were also built up via in situ preparation of gold nanoparticles (AuNPs) on the negatively charged surface of few‐layer graphene during the self‐assembly process. This study presents an approach to construct directly exfoliated graphene‐based hybrids through self‐assembly.
Identification of intranuclear inclusions is useful for the cytological diagnosis of ovarian clear cell carcinoma
Authors: Naka Masaki , Ohishi Yoshihiro , Kaku Tsunehisa , Watanabe Sumiko , Tamiya Sadafumi , Ookubo Fumihiko , Kato Kiyoko , Oda Yoshinao , Sugishima Setsuo
Published: July 2015

Objective

The aim of this study was to clarify the diagnostic significance of the presence of intranuclear inclusions in clear cell carcinoma (CCC).

Materials and Methods

We analyzed 98 imprint specimens and 53 ascites specimens from 98 ovarian carcinoma cases [28 CCCs, 37 serous carcinomas (SCs), 22 endometrioid carcinomas (ECs), and 11 mucinous carcinomas (MCs)]. We examined (1) frequency of intranuclear inclusion‐positive cases of each ovarian carcinoma subtype, using imprint specimens, (2) frequency of intranuclear inclusion‐positive cells of each ovarian carcinoma subtype, using imprint specimens, (3) frequency of intranuclear inclusion‐positive cases of each ovarian carcinoma subtype, using ascites specimens, and (4) sensitivity and specificity of the presence of intranuclear inclusions for the cytological diagnosis of CCC.

Results

(1) The frequency of intranuclear inclusion‐positive cases in CCC (96.4%) was significantly higher than in SC (13.5%), EC (13.6%), and MC (18.2%) (P < 0.001). Two or more intranuclear inclusions in a single nucleus were observed only in CCC. (2) The frequency of intranuclear inclusion‐positive cells in CCC (median, 0.41%) was significantly higher than in non‐CCC subtypes (0.010%) (P < 0.001). (3) Using ascites specimens, the frequency of intranuclear inclusion‐positive cases in CCC (78.6%) was significantly higher than in SC (10.3%), EC (0%), and MC (0%) (P < 0.001). (4) The sensitivity of intranuclear inclusions was 96.4%, and the specificity was 85.7%.

Conclusions

The identification of intranuclear inclusions, in particular a high frequency and multiple intranuclear inclusions in a single nucleus, is useful for the cytological diagnosis of CCC. Furthermore, these results may be applicable to ascites cytology. Diagn. Cytopathol. 2015;43:879–884. © 2015 Wiley Periodicals, Inc.
Characterization and Validation of a Canine Pruritic Model
Authors: Aberg Gunnar A.K. , Arulnesan Nada , Bolger Gordon T. , Ciofalo Vincent B. , Pucaj Kresimir
Published: July 2015

Preclinical Research

The mechanisms mediating canine pruritus are poorly understood with few models due to limited methods for inducing pruritus in dogs. Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice. We have developed a canine model of pruritus where CQ reliably induced pruritus in all dogs tested following intravenous administration. This model is presently being used to test antipruritic activity of drug candidate molecules. This publication has been validated in a blinded cross‐over study in eight beagle dogs using the reference standards, oclacitinib and prednisolone, and has been used to test a new compound, norketotifen. All compounds reduced CQ‐induced pruritus in the dog. The sensitivity of the model was demonstrated using norketotifen, which at three dose levels, dose‐dependently, inhibited scratching events compared with placebo. Drug Dev Res 76 : 246‐250, 2015. © 2015 Wiley Periodicals, Inc.
Mid wall fibrosis on CMR with late gadolinium enhancement may predict prognosis for LVAD and transplantation risk in patients with newly diagnosed dilated cardiomyopathy—preliminary observations from a high‐volume transplant centre
Authors: Venero Jose V. , Doyle Mark , Shah Moneal , Rathi Vikas K. , Yamrozik June A. , Williams Ronald B. , Vido Diane A. , Rayarao Geetha , Benza Raymond , Murali Srinivas , Glass Jerry , Olson Peter , Sokos George , Biederman Robert W.W.
Published: July 2015

Background

Patients with newly diagnosed dilated cardiomyopathy (DCM) and advanced heart failure have a very high morbidity and mortality with an unpredictable clinical course. We investigated the role of cardiovascular magnetic resonance (CMR) imaging using late gadolinium enhancement (LGE) in this cohort of high‐risk patients. We hypothesized that LGE has high prognostic value in primary DCM patients referred for possible transplantation/left ventricular assist device (LVAD) consideration.

Methods

Over 49 consecutive months, 61 consecutives DCM patients were referred for standard CMR(1.5T, GE) to interrogate the LV pattern, distribution, and extent of LGE (MultiHance, Princeton, NJ). Inclusion criteria for a primary non‐ischaemic DCM and EF <45% were met in 31 patients. DCM patients were categorized into: (i) presence of midwall LV stripe (+Stripe) and (ii) absence of midwall stripe (−Stripe) groups. Primary outcome was defined by the composite of death, need for LV assist device (LVAD), and urgent orthotopic cardiac transplantation (Tx) during a 12‐month follow‐up period. Kaplan–Meier survival analysis was conducted grouping patients by +Stripe and −Stripe.

Results

There were no differences between groups for demographics, blood pressure, labs, baseline LVEF, NYHA class, or invasive haemodynamics. There were 18 patients (58%) with +Stripe. Nine events occurred: seven patients required urgent Tx and/or LVAD implantation and two patients died. The +Stripe categorization strongly predicted the need for LVAD, urgent Tx surgery, and death (log‐rank = 9, P = 0.002). All the events occurred in the +Stripe patients with no MACE experienced in the −Stripe group. The −Stripe group experienced marked signs of improvement in LVEF (P = 0.01) at follow‐up. LVEDD was predictive of need for LVAD/Tx and death by univariate analysis. Otherwise, no common clinical metric such as LVEF, LVEDV, RVEF, RVEDV, or any invasive haemodynamic parameter predicted MACE.

Conclusions

The presence of +Stripe on CMR is strongly predictive of LVAD, transplant need, and death during a 12‐month follow‐up period in DCM patients in this proof of concept study. All −Stripe patients survived without experiencing any events. Incorporating CMR imaging into routine clinical practice may have prognostic value in DCM patients; indicating conservative management in low‐risk patients while expectantly managing high‐risk patients.
Heart failure as a general pandemic in Asia
Authors: Shimokawa Hiroaki , Miura Masanobu , Nochioka Kotaro , Sakata Yasuhiko
Published: July 2015

Heart failure (HF) is an epidemic in healthcare worldwide, including Asia. It appears that HF will become more serious in the near future, with the epidemiological transition and ageing of the population. However, in contrast to Western countries, information on HF epidemiology is still limited in Asia, particularly in South Asia. In this review, we will briefly summarize available information regarding the current and future burden of HF in Asia, which indicates the importance of both primary prevention of underlying diseases of HF and secondary prevention, including management of ischaemic HF, HF with preserved EF, and HF in the elderly.
Pretreatment of lignocellulosic biomass from animal manure as a means of enhancing biogas production
Authors: Muhammad Nasir Ismail , Mohd Ghazi Tinia Idaty
Published: July 2015

Biogas produced from lignocellulosic biomass, e.g. animal manure, has the potential to be a promising renewable energy source. Special emphasis has been placed on animal manure pretreatment in an anaerobic digestion as a means of enhancing biogas yield. Here, we review the existing pretreatment methods of anaerobic digestion with regard to their effects on the conversion of animal manure to biogas. Various methods and their challenges are highlighted. The effects of pretreatment are complex and usually depend on the animal waste characteristics and the method of choice. In general, pretreatment enhances the anaerobic digestion of the lignocellulosic content of the animal manure, by increasing the methane yield in similar operating conditions as those without the pretreatment.
Phytoremediation of heavy metal contaminated buriganga riverbed sediment by Indian mustard and marigold plants
Authors: Choudhury Mahbuboor Rahman , Islam Mohammad Shariful , Ahmed Zaki Uddin , Nayar Farnia
Published: July 2015

Locally available Indian mustard (Brassica juncea) and Marigold (Tagetes patula) plants can be used in a cost‐effective, environment‐friendly approach for treatment of landfills developed using heavy metal contaminated Buriganga riverbed sediments. In this study heavy metal uptake by Indian mustard and Marigold plants from heavy metal contaminated Buriganga riverbed sediments were assessed. Initial characterization of the Buriganga riverbed sediments showed concentrations of chromium, lead, copper, and zinc in the sediments higher than the toxicity reference values given for these heavy metals in soil for terrestrial plants, and soil invertebrate. The average background concentration of chromium, lead, copper, and zinc in the Buriganga riverbed sediments were found to be 141.5 mg/kg, 34.9 mg/kg, 38.7 mg/kg, and 287.5 mg/kg, respectively. Hence the newly developed area using such landfills poses a great threat to the surrounding flora and fauna. It was observed that both Indian mustard and Marigold plants accumulated these heavy metals in different parts of the plant from the contaminated sediments and were able to maintain a growth rate of more than 90% compared to that in noncontaminated soil. The results indicated rapid phytoextraction of most heavy metals by the Indian mustard during its final growth phase, whereas rapid phytoextraction of most heavy metals was observed in case of Marigold in its initial growth phase. Total chromium, lead, copper, and zinc uptakes (in mg/kg of plant dry weight) by Indian mustard plant in 12 weeks were 102.6, 28.9, 53, and 1861.5, respectively. The uptakes (in mg/kg of plant dry weight) of the same heavy metals by Marigold plant in 12 weeks were found to be 112.3, 104.25, 82.5, and 716.75, respectively. Marigold showed higher uptake efficiency for chromium, lead, and copper, while Indian mustard was found to be more efficient for zinc uptake. Hence both of these plants can be appropriately used as necessary for treating heavy metal contaminated landfills developed using Buriganga riverbed sediments. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 117–124, 2016
Thiamethoxam: Assessing flight activity of honeybees foraging on treated oilseed rape using radio frequency identification technology
Authors: Thompson Helen , Coulson Mike , Ruddle Natalie , Wilkins Selwyn , Harkin Sarah
Published: July 2015

The present study was designed to assess homing behavior of bees foraging on winter oilseed rape grown from seed treated with thiamethoxam (as Cruiser OSR), with 1 field drilled with thiamethoxam-treated seed and 2 control fields drilled with fungicide-only–treated seed. Twelve honeybee colonies were used per treatment group, 4 each located at the field edge (on-field site), at approximately 500 m and 1000 m from the field. A total of nearly 300 newly emerged bees per colony were fitted (tagged) with Mic3 radio frequency identification (RFID) transponders and introduced into each of the 36 study hives. The RFID readers fitted to the entrances of the test colonies were used to monitor the activity of the tagged bees for the duration of the 5-wk flowering period of the crop. These activity data were analyzed to assess any impact on flight activity of bees foraging on the treated compared with untreated crops. Honeybees were seen to be actively foraging within all 3 treatment groups during the exposure period. The data for the more than 3000 RFID-tagged bees and more than 90 000 foraging flights monitored throughout the exposure phase for the study follow the same trends across the treatment and controls and at each of the 3 apiary distances, indicating that there were no effects from foraging on the treated crop. Under the experimental conditions, there was no effect of foraging on thiamethoxam-treated oilseed rape on honeybee flight activity or on their ability to return to the hive. Environ Toxicol Chem 2016;35:385–393. © 2015 SETAC
Shelf life of ground beef enriched with omega‐3 and/or conjugated linoleic acid and use of grape seed extract to inhibit lipid oxidation
Authors: Gómez Inmaculada , Beriain María J. , Mendizabal Jose A. , Realini Carolina , Purroy Antonio
Published: July 2015

The shelf life and oxidative stability of refrigerated raw ground beef enriched with omega‐3 and/or conjugated linoleic acid (CLA) were studied. Grape seed extract (GSE) was used to inhibit lipid oxidation in the ground beef. Eight treatments of ground beef were established according to the enrichment of beef (control, enriched with omega‐3, with CLA, or with omega‐3 plus CLA) and the use of GSE (0 and 250 mg GSE/kg product). Fresh beef was ground and mixed with GSE and salt. Treatments of beef were stored at 2 ± 1°C in aerobic packaging for 0, 1, 3, and 6 days under retail display conditions. Oxidation stability (thiobarbituric acid‐reactive substances [TBARS]), pH, instrumental color, metmyoglobin formation, and sensory attributes (color and odor) were measured. Omega‐3‐enriched beef increased the oxidation level at day 6 as determined by TBARS (P < 0.05), but the instrumental color was not affected. The enrichment of CLA improved the coordinates of color (P < 0.05) until day 3 and decreased the oxidation at day 6 (P < 0.05). There were no differences in color and odor values among the types of beef during display, except at day 3, when CLA treatments had the highest scores. Addition of GSE decreased the oxidation level (P < 0.001) and did not affect the instrumental color or the sensory parameters.
Interpersonal traits of psychopathy linked to reduced integrity of the uncinate fasciculus
Authors: Wolf Richard C. , Pujara Maia S. , Motzkin Julian C. , Newman Joseph P. , Kiehl Kent A. , Decety Jean , Kosson David S. , Koenigs Michael
Published: July 2015

Psychopathy is a personality disorder characterized by callous lack of empathy, impulsive antisocial behavior, and criminal recidivism. Here, we performed the largest diffusion tensor imaging (DTI) study of incarcerated criminal offenders to date (N = 147) to determine whether psychopathy severity is linked to the microstructural integrity of major white matter tracts in the brain. Consistent with the results of previous studies in smaller samples, we found that psychopathy was associated with reduced fractional anisotropy in the right uncinate fasciculus (UF; the major white matter tract connecting ventral frontal and anterior temporal cortices). We found no such association in the left UF or in adjacent frontal or temporal white matter tracts. Moreover, the right UF finding was specifically related to the interpersonal features of psychopathy (glib superficial charm, grandiose sense of self‐worth, pathological lying, manipulativeness), rather than the affective, antisocial, or lifestyle features. These results indicate a neural marker for this key dimension of psychopathic symptomatology. Hum Brain Mapp 36:4202–4209, 2015. © 2015 Wiley Periodicals, Inc.
Population pharmacokinetics of meropenem during continuous infusion in surgical ICU patients
Authors: Kees Martin G. , Minichmayr Iris K. , Moritz Stefan , Beck Stefanie , Wicha Sebastian G. , Kees Frieder , Kloft Charlotte , Steinke Thomas
Published: July 2015

Continuous infusion of meropenem is a candidate strategy for optimization of its pharmacokinetic/pharmacodynamic profile. However, plasma concentrations are difficult to predict in critically ill patients. Steady‐state concentrations of meropenem were determined prospectively during continuous infusion in 32 surgical ICU patients (aged 21‐85 years, body weight 55‐125 kg, APACHE II 5‐29, measured creatinine clearance 22.7‐297 mL/min). Urine was collected for the quantification of renal clearance of meropenem and creatinine. Cystatin C was measured as an additional marker of renal function. Population pharmacokinetic models were developed using NONMEM®, which described total meropenem clearance and its relationship with several estimates of renal function (measured creatinine clearance CLCR, Cockcroft‐Gault formula CLCG, Hoek formula, 1/plasma creatinine, 1/plasma cystatin C) and other patient characteristics. Any estimate of renal function improved the model performance. The strongest association of clearance was found with CLCR (typical clearance = 11.3 L/h × [1 + 0.00932 × (CLCR – 80 mL/min)]), followed by 1/plasma cystatin C; CLCG was the least predictive covariate. Neither age, weight, nor sex was found to be significant. These models can be used to predict dosing requirements or meropenem concentrations during continuous infusion. The covariate CLCR offers the best predictive performance; if not available, cystatin C may provide a promising alternative to plasma creatinine.
Selection of microalgae for simultaneous biogas upgrading and biogas slurry nutrient reduction under various photoperiods
Authors: Wang Zhongwei , Zhao Yongjun , Ge Zhigang , Zhang Hui , Sun Shiqing
Published: July 2015

BACKGROUND

Five microalgal strains characterized by high biogas tolerance and rapid growth were cultured in biogas slurry to identify strains capable of simultaneous nutrient removal and biogas upgrading. The potential contribution of these algae to these processes was evaluated for different photoperiods.

RESULTS

The growth rates of the microalgae were inversely related to their initial concentrations. The growth rates of Scenedesmus obliquus (FACHB‐31), Chlorella vulgaris (FACHB‐416), and Nitzschia palea (FACHB‐211) were higher than those of Selenastrum capricornutum (FACHB‐271) and Anabaena spiroides (FACHB‐498) under a moderate photoperiod (14 h light: 10 h dark). Under this condition and an initial CH4 concentration of 61.38% (v/v), the final concentrations in crude biogas were 84.28%, 84.21%, and 83.46% for S. obliquus, C. vulgaris, and N. palea, respectively. Biogas slurry nutrients were optimally reduced under the moderate photoperiod.

CONCLUSION

Appropriate selection of microalgal strains for the treatment of biogas slurry and crude biogas is crucial to achieve optimal nutrient removal and biogas upgrading. © 2015 Society of Chemical Industry
Photocatalytic ozonation of pyridine‐based herbicides by N‐doped titania
Authors: Solís Rafael R , Javier Rivas F , Gimeno Olga , Pérez‐Bote José Luis
Published: July 2015

BACKGROUND

A mixture of three pyridine herbicides in water (clopyralid, triclopyr and picloram) has been treated with photocatalytic processes, involving oxygen or ozone. Nitrogen doped and undoped titania were used in the process. Toxicity evolution during photocatalytic ozonation was monitored considering BOD, Daphnia parvula and fitotoxicity trials.

RESULTS

N doped titania with an optimized photoactivity was tested in photocatalytic ozonation, leading to nearly 95% mineralization in 180 min. This catalyst was characterized by SEM, TEM, XRD and XPS techniques (13.5 nm crystal size, anatase phase, 1% N, and formation of O‐Ti‐N linkage). No loss of photocatalytic activity was observed after five consecutive runs. Although no toxicity from the parent compounds was observed, this parameter increased during the early stages of the oxidation process. When parent compounds were totally degraded and dechlorination was completed, toxicity decayed again to negligible values.

CONCLUSION

N doping improves bare titania photoactivity through an optimum amount of N. Photocatalysis/ozone showed better behavior than photocatalysis/oxygen in herbicide removal and mineralization, and no significant loss of activity was observed after five runs. Toxicity initially increased due to toxic byproducts formation; however, it decreased after their abatement. © 2015 Society of Chemical Industry
High resolution nanomechanical characterization of multi‐domain model membranes by fast Force Volume
Authors: Seghezza Silvia , Dante Silvia , Diaspro Alberto , Canale Claudio
Published: July 2015

Plasma membrane is a complex structure, mainly composed by lipids and proteins, which plays a pivotal role in cell metabolism by regulating its selective permeability to ions and molecules. According to the “raft hypothesis”, lipids in the bilayer are not forming a structurally passive solvent, but are rather organized in specific domains, which present different structural and functional characteristics. The mechanical properties of the lipid part of plasma membrane have been recently characterized through Atomic Force Microscopy, by analyzing the features of force vs distance curves collected on supported lipid bilayers (SLBs). In case of lipid domains sizing from tens to hundreds of nanometers, which mimic in a good way the lateral organization of real membranes, a high lateral resolution and a large number of curves are often required for properly expressing the complexity of the system, with a consequent exponential growth of acquisition and processing time. In this paper we propose a method, based on a recently developed high speed Force Volume technique and on home‐built data processing software, for the mechanical characterization of nanostructured SLBs. With our software we have been able to process data set composed by tens of thousands of curves, collected with a spatial resolution ranging from 8 to 40 nm/pixel. Multiparametric maps and distribution histograms produced by our analysis allowed identifying a specific behavior for each lipid phase in the investigated model membranes, even in presence of nanosized features. Copyright © 2015 John Wiley & Sons, Ltd.