bluuebunny/crossref_metadata_2025 huggingface dataset:
Emociones & Educación. La construcción histórica de la educación emocional
Authors: Mahamud Angulo Kira
Published: December 2019

Reseña del libro:  Agustín Escolano Benito.  Emociones & Educación. La construcción histórica de la educación emocional (Madrid: Visión Libros, 2018)
Colección "El papel de las mujeres"
Authors: Torres Pérez Lucía
Published: December 2019

Reseña de los libros de las colección "El papel de las mujeres" editada por Santillana Educación.
Listado de Evaluadores/as 2019
Authors: Canales Serrano Antonio Francisco
Published: December 2019

Listado de Evaluadores/as 2019
Citizenship by investment programmes: Express naturalisation for bulky wallets. An arbitrary de jure stratification?
Authors: Prats Elena
Published: December 2019

Traditionally, the study of the relation between stratification and migration has been focusing on features such as origin, ethnicity or gender, paying special attention to migrants at the bottom of the stratification. Recent studies (Shachar, 2011, 2016; Shachar & Hirschl, 2013) have shifted this lens by proving that there are worldwide ways to facilitate access to citizenship to applicants having exceptional talents —in sports, in academia or in industry—, most of them privileged by discretional decisions. Much less attention has caught the relation between stratification and programmes fast-tracking the route to citizenship in exchange for economic transactions. These are usually called citizenship by investment programmes (CIPs) and come in different forms. Yet all of them have in common the factor that economic capacity of the applicant is the key to access citizenship. By facilitating and speeding up the acquisition of citizenship on grounds of economic capacity, CIPs entail stratification in accessing citizenship that is established de jure or by law. This stratification in naturalisation requires further investigation and raises several questions: Is it fair to remove some requirements, such as civic and language tests, for checkbook citizens while keeping them for other naturalisation applicants? Should money be accepted as the main requirement to grant citizenship? Are these policies arbitrary? This paper has three objectives. First, to present the phenomenon of CIPs, focusing on programmes established by EU member states. Second, to compare the requirements applied to general applicants and to applicants following CIPs in order to prove that the programmes entail a de jure stratification in the access to citizenship. Third, to argue that these practices may be considered arbitrary.Summary:1. Introduction. 2. CIPs: a fast route to bulky wallets. 3. CIPs in the European Union (EU). (a) Bulgarian CIP. (b) Cypriot CIP. (c) Maltese CIP. 4. Is the stratification entailed by talented and checkbook citizens akin? 5. Last remarks
Modelos estatísticos para descrever o perfil do tronco do clone GG100 no Tocantins, Brasil
Authors: Terra David Lucas Camargo Vieira , Andrade Valdir Carlos Lima de
Published: December 2019

Este trabalho teve como objetivo avaliar o ajuste de modelos de taper com e sem casca para o clone GG100 em um plantio comercial localizado no sul do estado do Tocantins. Foram cubadas 25 árvores em cujos dados se ajustou cinco modelos de taper, sendo três representando os mais utilizados no Brasil e dois representando os modelos pouco testados no país. Na avaliação dos modelos de taper, adotou-se os critérios estatísticos: erro padrão da estimativa, coeficiente de determinação ajustado, desvio médio, soma de quadrados do resíduo relativo, resíduo percentual e análise da distribuição de resíduos. Concluiu-se por um modelo do tipo expoente-forma para descrever o perfil do tronco com e sem casca de árvores individuais do clone GG100.
Kontekst-orienteret ordkendskabsundervisning for elever i 5. klasse med begrænset dansk ordforråd: En undersøgelse af korttids- og langtidseffekter
Authors: Gellert Anna Steenberg , Wischmann Signe , Arnbak Elisabeth
Published: December 2019

Artiklen beskriver en undersøgelse af korttids- og langtidseffekter af et 24 lektioners kontekstorienteret ordkendskabsundervisningsforløb, der sigtede mod, at elever i 5. klasse med begrænset dansk ordforråd skulle lære dels at aktivere og opbygge viden om ord inden for bestemte semantiske felter, dels at udlede betydningen af ukendte ord i tekster vha. informationer i konteksten. 111 elever deltog i den kontekstorienterede ordkendskabsundervisning og blev sammenlignet med 221 andre elever, som enten deltog i en anden slags ordkendskabsundervisning eller blot modtog den sædvanlige undervisning på deres skole. Eleverne blev testet inden ordkendskabsundervisningen samt kort efter og igen ti måneder efter undervisningens afslutning. Undersøgelsen viste, at der umiddelbart efter undervisningen kunne konstateres meget stærke effekter af den kontekstorienterede ordkendskabsundervisning på elevernes læsning og definition af trænede ord samt en mellemstærk til stærk effekt på forståelse af tekster med sådanne ord. Ti måneder senere kunne der stadig påvises tydelige effekter af denne undervisning. Imidlertid kunne der ligesom i tidligere undersøgelser ikke spores overføringseffekter på elevernes generelle ordforråd eller generelle læseforståelse. Der kunne heller ikke påvises signifikante effekter af den kontekstorienterede undervisning på en test af elevernes færdigheder i at udlede ukendte ords betydning vha. konteksten. Sådanne effekter ville sandsynligvis kræve et mere omfattende undervisningsforløb.
Marketing touristique, pop culture et conflit d’appropriation
Authors: Sabre Clothilde
Published: December 2019

Le tourisme lié aux contenus de pop culture (bandes dessinées, manga, séries télévisées, films, animations, musique, jeux vidéo, etc.) concerne un nombre croissant de destinations et des campagnes de promotion (branding) se mettent en place pour valoriser la connexion entre sites et contenus, tandis que des aménagements sont entrepris sur le plan local afin de conformer les lieux à cette image issue des médias. Le Japon est un cas représentatif de ce phénomène, avec notamment le quartier d’Akihabara (Tokyo), lieu connu pour sa concentration de commerces en lien avec la pop culture japonaise, progressivement devenu un territoire dédié au tourisme de pop culture depuis le milieu des années 2000. Le succès global des contenus médiatiques japonais et la campagne de marketing qui a suivi (sous le slogan « Cool Japan ») ont ainsi justifié et influencé la rénovation du quartier. L’espace d’Akihabara, auparavant clos sur l’entre-soi des fans locaux stigmatisés (les otaku ), a été transformé en vitrine du Cool Japan, attirant ainsi un grand nombre de visiteurs, un processus paradoxal puisqu’il met en avant une identité acquise avec un groupe d’acteurs sociaux dévalorisés. Cet article propose de questionner la construction de l’identité touristique d’un site à travers le processus de valorisation urbaine conséquent au marketing territorial et au branding. Les aménagements et les représentations qui tirent parti de l’identité du site (ici la pop culture japonaise) forcent les différents groupes d’acteurs sociaux en présence à redéfinir leurs représentations et leurs pratiques, ce qui, comme on le verra ici, peut mener à un conflit d’appropriation déclenché par la mise en tourisme.
Jack Kerouac : un French guy pareil comme moi ?
Authors: Perreault Robert B.
Published: December 2019

L’auteur, Robert B. Perreault, un Franco-Américain de Manchester au New- Hampshire, raconte comment, en 1973, il a découvert l’oeuvre de l’écrivain Jack Kerouac lorsqu’un ami lui a mis entre les mains le volume Satori in Paris en lui disant : « C’est écrit par un French guy de la Nouvelle-Angleterre, pareil comme toi. » Après avoir lu ce livre, Perreault fait une étude approfondie du reste de l’oeuvre de Kerouac, ainsi que de sa vie et sa carrière, pour ensuite déterminer à quel point son ami avait raison en appelant Kerouac « un French guy de la Nouvelle-Angleterre comme [lui] ». Cet essai est donc le résultat de sa recherche.
Micro-Variables of Dynamic Capabilities and How They Come into Effect – Exploring Firm-Specificity and Cross-Firm Commonalities
Authors: Wilkens Uta , Sprafke Nicole
Published: December 2019

This paper gives emphasis to four categories most relevant for microfoundations of dynamic ca-pabilities (DCs): (1) leadership behavior, (2) team interaction, (3) individual capabilities, and (4) job characteristics. We study whether micro-variables operate firm-specifically when constituting DCs and how they relate to one another. Data result from employee surveys (n = 486) conducted in five German organizations. The cross-firm comparison based on discriminant analyses reveals that micro-variables that constitute DCs often build firm-specific configurations in a broader set of variables. Only structural empowerment and team learning function as cross-firm commonali-ties. There is evidence to consider firm-specificity when explaining competitive advantages.
Lien social et micro-fondations de la capacité dynamique d’expérimentation – Les enseignements d’une étude de cas
Authors: Malherbe Magali , Loilier Thomas
Published: December 2019

Cet article questionne les micro-fondations d’une capacité dynamique d’expérimentation mise en oeuvre à travers des projets d’innovation collaboratifs. Nous proposons un modèle conceptuel qui s’articule autour de trois niveaux d’analyse. Ainsi, des échanges inter-organisationnels suivant une logique de don / contre-don permettent de construire un lien social entre les individus. Ce lien social soutient ensuite la création et la mise en oeuvre de la capacité dynamique d’expérimentation. Fondés sur une étude de cas portant sur le secteur des technologies de l’information, les résultats montrent que les connaissances échangées alimentent des cycles de dons qui assurent les micro-fondations de la capacité dynamique d’expérimentation, cette dernière stimulant en retour les échanges.
Gender, Race, and Precarity: Theorizing the Parallels Between Early Childhood Educators and Sessional Faculty in Ontario
Authors: Abawi Zuhra , Berman Rachel , Powell Alana
Published: December 2019

This paper critically examines the parallels of devaluation encountered by early childhood educators and sessional faculty members in Ontario as reflective praxis. The three authors’ experiences are diverse and include a tenured professor and two sessional faculty members, both ofwhom have worked in the field of Early Childhood Education and Care (ECEC). The narratives of the authors inform the concerning trend of precarity and devaluation embedded within two polarizing spectrums of the Ontario educational landscape: Post-Secondary Education (PSE) and ECEC. Although these aforementioned areas of education rarely intersect, the authors centre them on the frontline of the neoliberal assault on education transpiring in Ontario today. The three authors self-identify as female settlers; two have doctoral degrees; one has an MA and is an early childhood educator (ECE). One author self-identifies as a racialized and white-coded cis-gendered woman, and two selfidentify as white, cis-gendered women. All of the authors have worked in Ontario’s post-secondary landscape, one as sessional faculty member and then a tenured professor, and two as sessional faculty members. The paper will problematize the neoliberal assault on higher education and ECEC through a Feminist Political Economy (FPE) conceptual framework in order to draw on the multifaceted ways femAtlantis Journal Issue 40.1 /2019 46 inized discourses devalue the work of ECEs and perpetuate the overrepresentation of women, particularly racialized women in precarious faculty positions.
El color escarlata en wikipedia
Authors: Escera Imma
Published: December 2019

La experiencia de Imma Escena consistió en la aportación de un artículo sobre el color escarlata en Wikipedia. En el siguiente artículo, Escera nos cuenta cómo fue el proceso de redacción y cómo siguió la estricta política de criterios de calidad que pauta el desarrollo de los artículos de la enciclopedia libre.
İklim Değişikliğinin Akdeniz Havzasındaki Orman Yangınlarına Etkisi
Authors: CALDA Burcu , AN Nazan , TURP Mustafa Tufan , KURNAZ Levent
Published: December 2019

İklim değişikliği ile birlikte son yıllarda Akdeniz Havzasında orman yangınlarının sayısında ciddi bir artış gözlenmiştir. Gerçekleşen bu yangınlar ormanlara doğal felaketlerden daha çok zarar vermektedir. Çıkan yangınların bir kısmı artan kurak hava koşulları nedeniyle doğal yollardan meydana gelirken, diğer bir kısmı ise ihmal ya da kasıt sonucunda oluşan ve büyük ölçüde iklim elemanlarının (sıcaklık, yağış, rüzgâr, nem vb.) etkisiyle büyüklüğü değişen yangınlar olarak ortaya çıkmaktadır. Orman yangınlarının öngörülmesinde kuraklık ile orman yangınları arasındaki ilişkiyi ele alan farklı indisler kullanılmaktadır. Bu çalışmada, olası orman yangınlarını öngörmek amacıyla yaygın olarak kullanılan yangın indislerinden; Haines İndisi (HI), Kanada Orman Yangın Hava İndisi (FWI), Keetch-Byram Kuraklık İndisi (KBDI), F İndisi detaylı olarak, Entegre Yangın İndisi (IFI), McArthur Mark 5 (Mk5) Orman ve Mark 4 (Mk4) Otlak Yangın Tehlike İndisi (McArthur Mark 5 (Mk5)), Fosberg Yangın Hava İndisi (FFWI), Nesterov İndisi (NI) ve Angström İndisi (AI) kısaca ele alınmıştır. İklim değişikliğinin orman yangınlarına etkisiyle ilgili yapılan çalışmalar kapsamında Antalya, Çanakkale ve Muğla Orman Bölge Müdürlüklerine bağlı orman arazilerinde 2008 ve 2009 yıllarında çıkan yangınlar Kanada Orman Yangın Hava İndisi (FWI) kullanılarak incelenmiştir. Sonuçlar 2008 ve 2009 yılı yangın verileri ile tutarlılık göstermiştir ve FWI değerleri bu yıllar için yangın riskini öngörmede başarılı bulunmuştur.
Endovascular treatment of ruptured tiny aneurysms
Authors: Kim Joon Hyuk , Choi Chang Hwa , Lee Jae Il , Lee Tae Hong , Ko Jun Kyeung
Published: December 2019

Objective

Endovascular coiling of ruptured tiny aneurysms (RTAs) in the brain has been known to be technically challenging owing to the higher rate of adverse events, such as thromboembolism and intraoperative rupture. The aim of this study was to report our ex-periences of endovascular treatment of RTAs (size, ≤3 mm).

Methods

From January 2006 to December 2017, 35 RTAs in 35 patients were treated at our institution with an endosaccular coiling. Procedural data and clinical and angiographic results were retrospectively reviewed.

Results

The mean size of the RTAs was 2.53 mm (SD: 0.38). The neck remodeling technique was applied to 14 aneurysms, including stent-assisted coiling (n=7) and balloon-assisted coiling (n=7). Procedure-related complications included intraprocedural rupture (n=2), thromboembolic event (n=1), and early rebleeding (n=2), which needed recoiling. Regarding immediate angiographic control, complete occlusion was achieved in 25 aneurysms (71.4%), small neck remnant in 5 (14.3%), and definite remnant in 5 (14.3%). At the end of follow-up, 31 of the 35 patients (88.6%) were able to function independently. Twenty-two of the 35 patients underwent follow-up conventional angiography (mean, 468 days). Stable occlusion was achieved in 20 of the 22 patients (90.9%), minor recanalization in 1 (4.5%), and major recanalization, which required recoiling, in 1 (4.5%).

Conclusion

Our experiences demonstrate that endovascular treatment for RTAs is both feasible and effective. However, periprocedural rebleedings were found to occur more often (11.4%) than what is generally suspected.
MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment
Authors: Beraldo Flavio H , Palmer Daniel , Memar Sara , Wasserman David I , Lee Wai-Jane V , Liang Shuai , Creighton Samantha D , Kolisnyk Benjamin , Cowan Matthew F , Mels Justin , Masood Talal S , Fodor Chris , Al-Onaizi Mohammed A , Bartha Robert , Gee Tom , Saksida Lisa M , Bussey Timothy J , Strother Stephen S , Prado Vania F , Winters Boyer D , Prado Marco AM
Published: December 2019

Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer’s disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.
Axon-like protrusions promote small cell lung cancer migration and metastasis
Authors: Yang Dian , Qu Fangfei , Cai Hongchen , Chuang Chen-Hua , Lim Jing Shan , Jahchan Nadine , Grüner Barbara M , S Kuo Christin , Kong Christina , Oudin Madeleine J , Winslow Monte M , Sage Julien
Published: December 2019

Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene programs but accumulating evidence indicates that these cancer cells become relatively more neuronal and less neuroendocrine as they gain the ability to metastasize. Here we show that mouse and human SCLC cells in culture and in vivo can grow cellular protrusions that resemble axons. The formation of these protrusions is controlled by multiple neuronal factors implicated in axonogenesis, axon guidance, and neuroblast migration. Disruption of these axon-like protrusions impairs cell migration in culture and inhibits metastatic ability in vivo. The co-option of developmental neuronal programs is a novel molecular and cellular mechanism that contributes to the high metastatic ability of SCLC.
Diversification of the Caenorhabditis heat shock response by Helitron transposable elements
Authors: Garrigues Jacob M , Tsu Brian V , Daugherty Matthew D , Pasquinelli Amy E
Published: December 2019

Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress. Remarkably, we found that substantial numbers of HSEs in multiple Caenorhabditis species reside within Helitrons, a type of DNA transposon. Consistent with Helitron-embedded HSEs being functional, upon heat shock they display increased HSF-1 and RNA polymerase II occupancy and up-regulation of nearby genes in C. elegans. Interestingly, we found that different genes appear to be incorporated into the HSR by species-specific Helitron insertions in C. elegans and C. briggsae and by strain-specific insertions among different wild isolates of C. elegans. Our studies uncover previously unidentified targets of HSF-1 and show that Helitron insertions are responsible for rewiring and diversifying the Caenorhabditis HSR.
Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala
Authors: Ostroff Linnaea E , Santini Emanuela , Sears Robert , Deane Zachary , Kanadia Rahul N , LeDoux Joseph E , Lhakhang Tenzin , Tsirigos Aristotelis , Heguy Adriana , Klann Eric
Published: December 2019

Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an established mechanism of synaptic plasticity and is regulated by learning, yet there is no evidence for learning-regulated protein synthesis in adult forebrain axons, which have traditionally been believed to be incapable of translation. Here, we show that axons in the adult rat amygdala contain translation machinery, and use translating ribosome affinity purification (TRAP) with RNASeq to identify mRNAs in cortical axons projecting to the amygdala, over 1200 of which were regulated during consolidation of associative memory. Mitochondrial and translation-related genes were upregulated, whereas synaptic, cytoskeletal, and myelin-related genes were downregulated; the opposite effects were observed in the cortex. Our results demonstrate that axonal translation occurs in the adult forebrain and is altered after learning, supporting the likelihood that local translation is more a rule than an exception in neuronal processes.
Limited initial impacts of biomass harvesting on composition of wood-inhabiting fungi within residual stumps
Authors: Boué Cédric , DeBellis Tonia , Venier Lisa A. , Work Timothy T. , Kembel Steven W.
Published: December 2019

Growing pressures linked to global warming are prompting governments to put policies in place to find alternatives to fossil fuels. In this study, we compared the impact of tree-length harvesting to more intensive full-tree harvesting on the composition of fungi residing in residual stumps 5 years after harvest. In the tree-length treatment, a larger amount of residual material was left around the residual stumps in contrast to the full-tree treatment where a large amount of woody debris was removed. We collected sawdust from five randomly selected residual stumps in five blocks in each of the tree-length and full-tree treatments, yielding a total of 50 samples (25 in each treatment). We characterized the fungal operational taxonomic units (OTUs) present in each stump using high-throughput DNA sequencing of the fungal ITS region. We observed no differences in Shannon diversity between tree-length and full-tree harvesting. Likewise, we observed few differences in the composition of fungal OTUs among tree-length and full-tree samples using non-metric multidimensional scaling. Using the differential abundance analysis implemented with DESeq2, we did, however, detect several associations between specific fungal taxa and the intensity of residual biomass harvest. For example, Peniophorella pallida (Bres.) KH Larss. and Tephromela sp. were found mainly in the full-tree treatment, while Phlebia livida (Pers.) Bres. and Cladophialophora chaetospira (Grove) Crous & Arzanlou were found mainly in the tree-length treatment. While none of the 20 most abundant species in our study were identified as pathogens we did identify one conifer pathogen species Serpula himantioides (Fr.) P. Karst found mainly in the full-tree treatment.
Resident microbes of lactation rooms and daycares
Authors: Taft Diana H. , Akre Samir , Madrid Nicolas , Knoesen Andre , Mills David A. , Lewis Zachery T.
Published: December 2019

Dedicated lactation rooms are a modern development as mothers return to work while still providing breastmilk to their absent infants. This study describes the built environment microbiome of lactation rooms and daycares, and explores the influence of temperature and humidity on the microbiome of lactation rooms. Sterile swabs were used to collect samples from five different sites in lactation rooms at University of California, Davis and from five different sites in daycares located in Davis, California. DNA from the swabs was extracted and the V4 region of the 16S rRNA gene was sequenced using Illumina MiSeq. Temperature and relative humidity data were collected on a subset of the lactation rooms. Sampled lactation rooms could be either dedicated lactation rooms or could also serve other functions (e.g., combined lactation room and restroom lounge). The majority of sequence reads were identified as belonging to family Moraxellaceae, with 73% of all reads included in analysis identified as an unknown species ofAcinetobacter. Alpha diversity was analyzed using the Shannon index, while beta diversity was analyzed using unweighted and weighted UniFrac distance. The Jaccard distance was used to measure amount of change at sampling locations between time points for analysis of the impact of temperature and humidity on the microbiome. There were significant differences in the beta diversity of the microbiome of lactation rooms by room type. There were also significant differences in the beta diversity of the microbiome by sample collection location. There were no significant differences in either alpha or beta diversity associated with room temperature or humidity. Additional studies are needed to understand if the differences in lactation room type may result in differences in the breastmilk microbiome of milk collected in those rooms, and to what extent any such differences may influence the infant microbiome.
Prosaposin in seminal plasma on the day of oocyte retrieval is associated with normal fertilization and embryo development in in vitro fertilization cycles
Authors: Xu Chun , Cai Jiali , Liu Lanlan , Ren Jianzhi
Published: December 2019

The prospective study including 166 participants aims to evaluate the association between seminal prosaposin and the outcomes of in vitro fertilization (IVF) cycles in humans. The generalized linear model (GLM) was used to analyze the associations between seminal prosaposin concentrations and normal fertilization rates and good embryos proportion. The generalized estimating equation (GEE) was used to evaluate the association between embryo parameters and the prosaposin concentrations. Each model was adjusted for age of the couples, female basal FSH, AFC and BMI, starting dose and oocyte yield of IVF cycles and smoker. GLM models suggested that prosaposin was significantly associated with fertilization rate (P = 0.005) and good embryo proportion (P = 0.038) while none of the semen parameters (sperm concentration, motility, progressive motility, normal morphology rate, postwash sperm concentration and motility) was significantly associated with the parameters in the cohort. Using GEE, it was also shown that prosaposin was positively associated with the occurrence of early cleavage and negatively associated with uneven cleavage pattern on day 3. In both the overall population and the normozoospermia patients, the prosaposin was significantly associated with pregnancy with adjustment with covariates. In conclusion, our data suggested that seminal prosaposin concentration could provide more information regarding normal fertilization and embryo development in IVF than traditional semen parameters.
CFD Simulation of Heat Transfer from Elliptic Tube Bundle Buried in a Bubbling Fluidized Bed
Authors: Abd-Rabbo M. A. , Sakr R. Y. , Mohammad M. A. , Mandour M. M.
Published: December 2019

In the present work, numerical simulations are performed to study heat transfer characteristics and fluid flow around elliptic tube heat exchanger. The results for heat transfer coefficient between immersed inline and staggered bundles of horizontal smooth tubes and air-fluidized bed of pulverized coal, dp = 2 mm, are reported within the range of fluidization number, Usup/ Umf, ranges from 1 to 1.4. Heat transfer as well as multiphase flow dynamics in fluidized bed is modelled using the Eulerian-Eulerian and the Two-Fluid Model (TFM) with Kinetic Theory of Granular Flow (KTGF) to describe the granular flow characteristics of the solid phase. The average heat transfer coefficient for the present work is compared with that obtained from the well-known correlation of circular cylinder and a noticed improvement is observed. It is noticed that, the average Nusselt number increases with fluidization number. Also, it is noticed that, the average Nusselt number in case of staggered tubes bundle is higher than the case of inline tubes bundle. The inline tube bundle has lesser pressure drop than the staggered tube bundle.
Effect of Tillage and Weed Control Techniques on Energy Dynamics and Profitability of Chickpea (Cicer arietinum L.) - Rice Cropping Sequence in Irrigated Ecosystem of C. G. Plains
Authors: Ahmad Anjum , Chowdhury T. , Kumar Adyant
Published: December 2019

A field study was conducted during rabi seasons of 2010-11 and 2011-12 at the Research cum Instructional Farm of Indira Gandhi Krishi Vishwavidyalaya, Raipur, Chhattisgarh to evaluate the effect of various tillage and weed management techniques on energy dynamics and profitability of chickpea-rice cropping sequence in irrigated ecosystem of C.G. plains. The results indicate that plots were divided into main and sub plots (tillage and weed management practices). Three tillage practices viz., conventional tillage (T1),  minimum tillage (T2) and zero tillage (T3) in main plot and nine weed management practices as pendimethalin @ 1000 g ha-1 PE (W1), imazethapyr @ 80 g ha-1 PE (W2), imazethapyr @ 90 g ha-1 PE (W3), imazethapyr @ 100 g ha-1 PE (W4) at 2 DAS, imazethapyr @ 70 g ha-1 POE (W5), imazethapyr @ 80 g ha-1 POE (W6), imazethapyr @ 90 g ha-1 POE (W7) at 20 DAS, one hand weeding at 20 DAS (W8) and weedy check (W9), in sub plots. Among the various tillage practices, maximum energy use efficiency 3.74 q MJ-1 × 10-3 ha-1 and energy productivity 160.34 kg MJ-1 ha-1 were obtained with conventional tillage (T1) followed by minimum tillage (T2) and zero tillage (T3) and among the different weed control methods, maximum energy use efficiency 5.46 q MJ-1 × 10-3 ha-1 and energy productivity 233.37 kg MJ-1 ha-1 were found with one hand weeding at 20 DAS (W8) followed by post-emergence application of imazethapyr @ 90 g ha-1 (W7) followed by imazethapyr @ 80 g ha-1 PoE (W6). The economic production of experiment in terms of net return was maximum under (T1) conventional tillage Rs.19824.21 ha-1 with B:C ratio 1.19 and (W8) one hand weeding at 20 DAS Rs.19171.44 ha-1 with B:C ratio 0.95 and this was followed by @ 90 g ha-1 imazethapyr, where net return Rs.19086.74 ha-1 and B:C ratio 1.04. The minimum net return and B:C ratio was observed under zero tillage (T3) and weedy check (W9).
Silencing of IL13RA2 promotes partial epithelial‐mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation
Authors: Wang Mimi , Yao Rongrong , Wang Yanhong
Published: December 2019

Lack of insight into the mechanisms underlying hepatocellular carcinoma (HCC) metastasis has hindered the development of curative treatments. Overexpression of interleukin‐13 receptor alpha 2 (IL13RA2) has been reported to contribute to invasion and metastasis in several tumors. However, the role of IL13RA2 in HCC remains to be characterized. In this study, we identified that low expression of IL13RA2 is associated with poor survival of patients with HCC, and demonstrated that IL13RA2 knockdown endows HCC cells with invasive potential. Mechanistically, silencing of IL13RA2 promotes partial epithelial‐mesenchymal transition via increasing extracellular signal‐regulated kinase phosphorylation in HCC. Collectively, our results suggest that IL13RA2 may have potential as a prognostic biomarker for HCC.
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome
Authors: En Atsuki , Takauji Yuki , Miki Kensuke , Ayusawa Dai , Fujii Michihiko
Published: December 2019

Cellular senescence is a terminal growth arrest phenomenon in mammalian cells. Coordinated regulation of protein synthesis and degradation is required to maintain protein homeostasis in cells; however, senescent cells exhibit decreased activity of the proteasome, a major cellular proteolytic machinery, with an accumulation of proteins. Indeed, we showed that MG132, a proteasome inhibitor, induced cellular senescence through an accumulation of proteins in human cells. We then investigated the mechanisms of cellular senescence induced by protein accumulation by treating cells with MG132. We found that lamin B receptor (LBR), a nuclear membrane protein that regulates heterochromatin organization, was mislocalized and down‐regulated in cells on treatment with MG132. Importantly, enforced expression of LBR suppressed cellular senescence induced by MG132. We also showed that LBR was involved in the regulation of chromatin organization in senescent cells, and that endoplasmic reticulum stress and autophagy were likely to be involved in the mislocalization and down‐regulation of LBR. These findings indicate that decreased LBR function was responsible for the induction of cellular senescence by MG132, and thus suggest that protein accumulation caused by inhibition of the proteasome induced cellular senescence probably through chromatin dysregulation in human cells.
Evaluation of Bystander Infection of Oncolytic Virus using a Medium Flow Integrated 3D In Vitro Microphysiological System
Authors: Lee Sang Woo , Lee Kyoung Jin , Jeong Soo Yeon , Joo Chul Hyun , Lee Heuiran , Jeong Gi Seok
Published: December 2019

Replicable oncolytic viruses (OVs) induce tumor cell lysis and release viral progeny. The released progeny virions and cell debris can spread within surrounding tumor cells or blood vessels. These released molecules may also induce bystander damage in additional tumor cells through spreading within surrounding tumor cells or blood vessels. However, this effect has not been clearly demonstrated due to the difficulty of direct observation. Here, the bystander infection of OVs by vessel delivery and selective infection in 3D multicellular tumoroids (MCTs) in an in vitro microphysiological system (MPS) with integrated medium flow is demonstrated. This study uses replicable vesicular stomatitis virus (VSV)‐green fluorescence protein (GFP) to identify the location of infection in 3D MCTs. Using this MPS, the oncoselective infection by VSV‐GFP and the spreading by delivery of OVs through flow via block‐to‐block linkage of the primary infected MPS with uninfected 3D MCTs in an integrated MPS is observed. This MPS enables real‐time monitoring and various analysis for the bystander infection of OVs. It is expected that the 3D in vitro MPS can be suitable to investigate the oncoselective spreading and bystander infection of OVs.
Superoleophobic Filters: Improvement of Filtration Performance by Front Attachment of Oil‐Guiding Fabric
Authors: Liu Jialin , Zhou Hua , Wu Xiaolin , Wang Hongxia , Ji Zhongli , Xing Yanning , Lu Jinjie , Wei Xin , Lin Tong
Published: December 2019

In this paper, a novel, simple, but efficient method is reported to lower pressure drop and meanwhile maintain high filtration efficiency of superoleophobic filters for oil aerosol filtration. By close attachment of a thin oil‐guiding fibrous layer to the front surface of a superoleophobic filter, the pressure drop at pseudostatic state can be reduced by 20%. Such a remarkable reduction in filtration resistance is originated from the capillary effect of the oil‐guiding fabric, and pore size within the guiding fabric also played a role. This novel material may be useful for the development of high efficiency, low energy‐consumption coalescing filters for various applications.
Analog Optical Spatial Differentiators Based on Dielectric Metasurfaces
Authors: Zhou Yi , Wu Wenhui , Chen Rui , Chen Wenjie , Chen Ruipin , Ma Yungui
Published: December 2019

Analog spatial differentiator is an important optical computational device that can be potentially used in the field of high‐speed edge detection and optical image processing. In the current stage, a general method is still required to robustly design compact devices for various spectrum or complex situation. In this work, a dielectric metasurface method is proposed and experimentally demonstrated to build optical spatial differentiators. This is physically realized by a high‐quality magnetic resonance mode that is hybridized with the classic bounded surface wave via grating coupling. Experimentally, a well‐defined first‐order differentiation effect is observed at oblique light incidence. The application potential of this device is evaluated by inputting various figures. It is shown that it can perform an optical processor to trace the profiles of the figure content with a resolution better than 30.8 µm. This work may pave a robust way to build ultracompact optical computation devices for real‐time image processors, which can be freely extended to various frequencies.
Root Growth Adaptation is Mediated by PYLs ABA Receptor‐PP2A Protein Phosphatase Complex
Authors: Li Yang , Wang Yaping , Tan Shutang , Li Zhen , Yuan Zhi , Glanc Matouš , Domjan David , Wang Kai , Xuan Wei , Guo Yan , Gong Zhizhong , Friml Jiří , Zhang Jing
Published: December 2019

Plant root architecture dynamically adapts to various environmental conditions, such as salt‐containing soil. The phytohormone abscisic acid (ABA) is involved among others also in these developmental adaptations, but the underlying molecular mechanism remains elusive. Here, a novel branch of the ABA signaling pathway in Arabidopsis involving PYR/PYL/RCAR (abbreviated as PYLs) receptor‐protein phosphatase 2A (PP2A) complex that acts in parallel to the canonical PYLs‐protein phosphatase 2C (PP2C) mechanism is identified. The PYLs‐PP2A signaling modulates root gravitropism and lateral root formation through regulating phytohormone auxin transport. In optimal conditions, PYLs ABA receptor interacts with the catalytic subunits of PP2A, increasing their phosphatase activity and thus counteracting PINOID (PID) kinase‐mediated phosphorylation of PIN‐FORMED (PIN) auxin transporters. By contrast, in salt and osmotic stress conditions, ABA binds to PYLs, inhibiting the PP2A activity, which leads to increased PIN phosphorylation and consequently modulated directional auxin transport leading to adapted root architecture. This work reveals an adaptive mechanism that may flexibly adjust plant root growth to withstand saline and osmotic stresses. It occurs via the cross‐talk between the stress hormone ABA and the versatile developmental regulator auxin.
Elucidating the Role of a Tetrafluoroborate‐Based Ionic Liquid at the n‐Type Oxide/Perovskite Interface
Authors: Noel Nakita K. , Habisreutinger Severin N. , Wenger Bernard , Lin Yen‐Hung , Zhang Fengyu , Patel Jay B. , Kahn Antoine , Johnston Michael B. , Snaith Henry J.
Published: December 2019

Halide perovskites are currently one of the most heavily researched emerging photovoltaic materials. Despite achieving remarkable power conversion efficiencies, perovskite solar cells have not yet achieved their full potential, with the interfaces between the perovskite and the charge‐selective layers being where most recombination losses occur. In this study, a fluorinated ionic liquid (IL) is employed to modify the perovskite/SnO2 interface. Using Kelvin probe and photoelectron spectroscopy measurements, it is shown that depositing the perovskite onto an IL‐treated substrate results in the crystallization of a perovskite film which has a more n‐type character, evidenced by a decrease of the work function and a shift of the Fermi level toward the conduction band. Photoluminescence spectroscopy and time‐resolved microwave conductivity are used to investigate the optoelectronic properties of the perovskite grown on neat and IL‐modified surfaces and it is found that the modified substrate yields a perovskite film which exhibits an order of magnitude lower trap density than the control. When incorporated into solar cells, this interface modification results in a reduction in the current–voltage hysteresis and an improvement in device performance, with the best performing devices achieving steady‐state PCEs exceeding 20%.
Lifting off a solid sphere from a flat bottom by laminar fluid flow
Authors: Wang Chao , Wang Hanbin , Zhang Kun , Li Zhipeng , Gao Zhengming , Derksen Jos J.
Published: December 2019

We perform quantitative visualization experiments on the vertical (z‐direction) motion of a spherical solid particle being lifted off a horizontal flat bottom due to laminar fluid flow generated by a revolving impeller. Describing the observed motion of the particle in terms of a constant vertical hydrodynamic force overcoming gravity and the lubrication force has limited success. For this reason, we hypothesize that the hydrodynamic force on the particle quickly increases with its distance from the bottom. This hypothesis is supported by detailed numerical simulations of the flow around the particle. Integrating the equation of motion of the sphere with the vertical hydrodynamic force as a linear function ofzderived from simulations provides an adequate description of the experimentally observed vertical motion of the particle.
Providing more evidence on LZTR1 variants in Noonan syndrome patients
Authors: Chinton Josefina , Huckstadt Victoria , Mucciolo Mafalda , Lepri Francesca , Novelli Antonio , Gravina Luis Pablo , Obregon María Gabriela
Published: December 2019

Noonan syndrome (NS, OMIM 163950) is a common autosomal dominant RASopathy caused mainly by gain‐of‐function germline pathogenic variants in genes involved in the RAS/MAPK signaling pathway. LZTR1 gene has been associated with both dominant and recessive NS. Here, we present seven patients with NS and variants in the LZTR1 gene from seven unrelated families, 14 individuals in total. The detection rAte of LZTR1 variants in our NS cohort was 4% similar to RAF1 and KRAS genes, indicating that variants in this gene might be frequent among our population. Three different variants were detected, c.742G>A (p.Gly248Arg), c.360C>A (p.His120Gln), and c.2245T>C (p.Tyr749His). The pathogenic variant c.742G>A (p.Gly248Arg) was found in five/seven patients. In our cohort 50% of patients presented heart defects and neurodevelopment delay or learning disabilities, short stature was present in 21% of them and one patient had acute lymphoblastic leukemia. This study broadens the spectrum of variants in the LZTR1 gene and provides increased knowledge of the clinical phenotypes observed in Argentinean NS patients.
Ecological and social determinants of association and proximity patterns in the fission–fusion society of spider monkeys (Ateles geoffroyi)
Authors: Aguilar‐Melo Adriana R. , Calmé Sophie , Pinacho‐Guendulain Braulio , Smith‐Aguilar Sandra E. , Ramos‐Fernández Gabriel
Published: December 2019

Some social species exhibit high levels of fission–fusion dynamics (FFD) that improve foraging efficiency. In this study, we shed light on the way that FFD allows animal groups to cope with fluctuations in fruit availability. We explore the relative contribution of fruit availability and social factors like sex in determining association and proximity patterns in spider monkeys. We tested the influence of fruit availability and social factors on the association and proximity patterns using three‐year data from a group of spider monkeys in the Yucatan Peninsula of Mexico. We identified subgroup members and estimated their Interindividual distances through instantaneous scan sampling. We evaluated fruit availability by monitoring the phenology of the 10 most important food tree species for spider monkeys in the study site. Social network analyses allowed us to evaluate association and proximity patterns in subgroups. We showed that association patterns vary between seasons, respond to changes in fruit availability, and are influenced by the sex of individuals, likely reflecting biological and behavioral differences between sexes and the interplay between ecological and social factors. In contrast, proximity patterns were minimally affected by changes in fruit availability, suggesting that social factors are more important than food availability in determining cohesion within subgroups.
The influence of mobility strategy on the modern human talus
Authors: Sorrentino Rita , Stephens Nicholas B. , Carlson Kristian J. , Figus Carla , Fiorenza Luca , Frost Stephen , Harcourt‐Smith William , Parr William , Saers Jaap , Turley Kevin , Wroe Stephen , Belcastro Maria G. , Ryan Timothy M. , Benazzi Stefano
Published: December 2019

Objectives

The primate talus is known to have a shape that varies according to differences in locomotion and substrate use. While the modern human talus is morphologically specialized for bipedal walking, relatively little is known on how its morphology varies in relation to cultural and environmental differences across time. Here we compare tali of modern human populations with different subsistence economies and lifestyles to explore how cultural practices and environmental factors influence external talar shape.

Materials and Methods

The sample consists of digital models of 142 tali from 11 archaeological and post‐industrial modern human groups. Talar morphology was investigated through 3D (semi)landmark based geometric morphometric methods.

Results

Our results show distinct differences between highly mobile hunter‐gatherers and more sedentary groups belonging to a mixed post‐agricultural/industrial background. Hunter‐gatherers exhibit a more “flexible” talar shape, everted posture, and a more robust and medially oriented talar neck/head, which we interpret as reflecting long‐distance walking strictly performed barefoot, or wearing minimalistic footwear, along uneven ground. The talus of the post‐industrial population exhibits a “stable” profile, neutral posture, and a less robust and orthogonally oriented talar neck/head, which we interpret as a consequence of sedentary lifestyle and use of stiff footwear.

Discussion

We suggest that talar morphological variation is related to the adoption of constraining footwear in post‐industrial society, which reduces ankle range of motion. This contrasts with hunter‐gatherers, where talar shape shows a more flexible profile, likely resulting from a lack of footwear while traversing uneven terrain. We conclude that modern human tali vary with differences in locomotor and cultural behavior.
Selbstorganisation in Wasser mit N‐substituierten Aminen
Authors: Jiao Tianyu , Wu Guangcheng , Zhang Yang , Shen Libo , Lei Ye , Wang Cai‐Yun , Fahrenbach Albert C. , Li Hao
Published: December 2019

Die Iminsynthese hat eine lange Geschichte als dynamische kovalente Reaktion der Wahl für die Konstruktion rein kovalenter molekularer Architekturen. In organischen Lösungsmitteln ist die Entstehung von Iminbindungen reversibel, die Produkte sind aber thermodynamisch stabil. In Gegenwart von Wasser sind Iminbindungen dagegen labil, ein Umstand, der ihren Nutzen als Vermittler von Selbstorganisation in wässrigen und biologischen Medien beschränkt. In diesem Aufsatz besprechen wir wasserkompatible dynamische kovalente Bindungen auf der Basis von N‐substituierten Iminderivaten, nämlich Hydrazonen und Oximen, für die Selbstorganisation metallfreier organischer Architekturen mit gut definierten Strukturen. Wir erläutern die Gründe, warum Hydrazone und Oxime in Wasser robuster sind als ihre Ausgangsimine, und beleuchten aktuelle Fortschritte auf dem Gebiet der Selbstorganisation, der Charakterisierung und der Designprinzipien verschiedener komplexer Moleküle, einschließlich Makrozyklen, Käfige, Catenane und Knoten, in wässrigen Medien. Auch neue Anwendungen dieser Moleküle, einschließlich Gasterkennung und ‐abtrennung, werden besprochen.
An N‐Heterocyclic‐Carbene‐Derived Distonic Radical Cation
Authors: Gallagher Nolan M. , Ye Hong‐Zhou , Feng Shuting , Lopez Jeffrey , Zhu Yun Guang , Van Voorhis Troy , Shao‐Horn Yang , Johnson Jeremiah A.
Published: December 2019

We present the discovery of a novel radical cation formed through one‐electron oxidation of an N‐heterocyclic carbene–carbodiimide (NHC–CDI) zwitterionic adduct. This compound possesses a distonic electronic structure (spatially separate spin and charge regions) and displays persistence under ambient conditions. We demonstrate its application in a redox‐flow battery exhibiting minimal voltage hysteresis, a flat voltage plateau, high Coulombic efficiency, and no performance decay for at least 100 cycles. The chemical tunability of NHCs and CDIs suggests that this approach could provide a general entry to redox‐active NHC–CDI adducts and their persistent radical ions for various applications.