bluuebunny/crossref_metadata_2025 huggingface dataset:
Clincal analysis of 85 patients with multiple primary gastrointestinal malignant tumors
Authors: Peng Lingzhi , Xu Yan , Zhu Chenglou , Liu Tianxiang , Da Mingxu
Published: April 2023

Objectives: The aim of this study was to analyze the incidence, clinical features, treatment factors, prevalence, and prognosis of patients with multiple primary malignant tumors (MPMTs) in the gastrointestinal tract. Additionally, we aimed to analyze the different tumor combinations, the time interval between the occurrence of tumors, and staging.
Methods: This retrospective cohort study analyzed 8059 patients for pathologically confirmed gastrointestinal malignant tumors at the Gansu Province Hospital in Lanzhou, Gansu, China between June 2011 and June 2020. Of these, 85 patients had MPMTs. Their data were analyzed for clinical features, treatment factors, prevalence, and prognosis.
Results: The incidence of MPMTs was 1.05% (85/8059) in patients with gastrointestinal malignant tumors; that of synchronous multiple primary malignant tumors (SMPMTs) was 28 (32.94%); and that of metachronous multiple primary malignant tumors (MMPMTs) was 57 (67.06%), including 83 double primary malignant tumors and two triple primary malignant tumors. The most frequent associations were between the rectum colon cancers within the SMPMT category and the gastric-colon cancers within the MMPMT category. For the MMPMTs, the median interval was 53 months. The overall 1-, 3- and 5-year survival rates from diagnosis of the first primary cancer were 91.36%, 65.41%, and 45.97%, respectively; from diagnosis of the second primary cancer, they were 67.90%, 29.90%, and 17.37%, respectively.
Conclusions: Our results suggest that MPMTs in the gastrointestinal tract have a high incidence and poor prognosis. Thus, it is necessary to perform both gastroscopy and colonoscopy in patients with gastrointestinal tumors. Multidisciplinary comprehensive diagnosis and treatment may improve the diagnosis rate and treatment efficiency of MPMTs.
Effectiveness of Phthorimaea Operculella (Zeller) (Lepidoptera: Gelechidae) Potato Tuber Moth -Traps of Different Colors Baited with Pheromone in Summer Plantation
Authors: Gharib Mohamed Refaat
Published: April 2023

Background
In agricultural regions, traps can be used to track target pests using particular pheromones.
Result
Evaluation of the effects of trap color, trap direction, and trap location on Phthorimaea operculella (Zeller) captures of the potato moth. A pheromone capsule served as bait for each trap. More insects were captured by white pheromone traps than by yellow, blue, green, or red traps. The mean catches of the white and other coloured traps were found to vary significantly. Although there are negligible differences between the mean catches at each direction, the trap caught more moths when it was placed in the south or centre of the infested region than when it was placed in the west, east, or north. When compared to the two other locations (50 and 100 cm above the ground), the collective capture of P. Operculella moths made by the ground-resting traps was greater. A comparison test of catches revealed significant differences between the 0 cm position (rested on the ground) and the other two positions.
Conclusion
When creating a monitoring system for P. operculella trapping system, these results should be taken into consideration.
Self-assembly and solution behavior of cationic surfactants in water- trifluoroethanol environment: An experimental and theoretical approach
Authors: Kumar Vinod , Padsala Shailesh , Mayursing Girase , Ray Debes , Aswal Vinod Kumar , Kuperkar Ketan , Bahadur Pratap
Published: April 2023

Self-assembly and micellization performance of cationic conventional surfactant: tetradecyltrimethylammonium bromide (TTAB) and gemini surfactant (GS): N,N′-ditetradecyl-N,N,N′,N′-tetramethyl-N,N′-ethanediyl-diammonium dibromide (14-2-14) were investigated in water and water-trifluoroethanol (TFE) solvent mixture using tensiometry and small-angle neutron scattering (SANS) techniques. The micellization parameter critical micelle concentration (CMC) for our examined systems was evaluated at the air-water interface at 303.15 K using tensiometry. It was found that CMC of the cationic surfactants decrease with increasing the concentration of TFE thereby indicating micellization process getting influenced by the addition of surface-active TFE. The shape and aggregation number (Nagg) of the surfactant micelles were evaluated as a function of TFE using SANS which revealed the decrease in micelle size of cationic surfactants. In addition, the computational simulation study is undertaken to offer an insight into the interactions involved between the examined cationic surfactants and TFE system.
Molecular Detection and charchterization of stx toxins of Escherichia coli O157:H7, Escherichia coli O26:H8, and Escherichia coli O111:H8 from diarrhoeic patients in Khartoum State, Sudan
Authors: Musa Hassan Abd Alaziz , Ahmed Rolla Abdalkader , Babikir Ibrahim Hassan
Published: April 2023

Introduction/Background: Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is the most important serotype of E. coli responsible for serious intestinal and extra-intestinal disorders worldwide, but no molecular based study for EHEC as the causative agent diarrhea was performed in the Sudan. EHEC is a subset of Shiga toxin (stx) producing E. coli (STEC) which includes well recognized human pathogens. STEC produce high level toxins of a protein family referred to as Shiga toxin and Shiga-like toxins (SLTs; alternatively known as verocytotoxins VTEC or VTs). EHEC O26:H11 and O111:H8 have emerged as the most important non-O157:H7 EHEC.
These toxins are mediating intestinal disease in children and adults, and if the cases left untreated these toxins may contribution to the development of extra-intestinal sequelae e.g., the haemolytic uraemic syndrome and neurological disorders.
Objective: This study was conducted for the detection and molecular characterization of Shiga like toxin (stx) of E. coli O157:H7, E. coli O26:H11, and E. coli O111:H8 in Sudanese patients with diarrhea using PCR and multiplex PCR.
Materials and methods: A cross sectional laboratory-based study was carried out in Khartoum, Sudan during the period from June to October 2020. All patients with confirmed E. coli diarrheal disease was included in this study. The isolates have been identified by using the biochemical, serological, molecular identification and characterization tests. SPSS IBM (software version 20.0) was used for analyses.
Results: Out of 100 patients with diarrheal disease a total of 96 patients were confirmed of having E. coli organisms. All 96 E. coli bacteria were seropositive identified as members of the EHEC. Ten isolates of E. coliO157:H7, E. coli O26:H11, E. coli O111:H8 have been selected as follows; five, three, and two respectively.
The selected isolates followed by multiplex PCR to detect the genes of stx toxins of E. coli O157:H7, E. coli, O26:H11, and E. coli O111:H8 and comparing between them.
The multiplex PCR revealed that E. coli O157:H7 were carrying stx1 and stx2 genes represented by two bands, while E. coliO26:H11 and E. coli O111:H8 were carrying one stx2 gene represented by one band.
Conclusions: E. coli O157:H7 produce stx1 and stx2 while the other serotypes E. coli O26:H11 and E. coli O111:H8 produce stx2 only.
Effective control of pathogenic strains of E. coli requires a multifaceted approach. To reduce the frequency and severity of human exposure to STEC, controlling dietary sources and environmental sources such as cattle, water troughs, feed and manure is critical in breaking the cycle of infection and re-reinfecting with STEC.
Chaos control and numerical solution of time-varying fractional Newton-Leipnik system using fractional Caputo-Fabrizio derivatives
Authors: ALMUTAIRI Najat , Saber Sayed
Published: April 2023

In this work, a design of a constant and time-varying fractional Newton-Lepnick system is developed to understand its chaotic properties. Due to the nonlocal nature of the method, the Newton-Leipnik system is generated using a generalized power law, a power law and another fractional derivative based on the Mittag-Leffler function developed as a kernel. We solve the model using the numerical Caputo-Fabiesu method, but also test their existence and uniqueness. These schemes are applied to oscillators of chaotic Newton-Lepnic systems based on simulated chaotic circuits. Chaos control is performed by a linear controller. Furthermore, the Lyapunov exponent of the system indicates that the chaos control results are correct. We demonstrate the applicability and effectiveness of this method with a numerical example. Numerical simulation of the controller is provided.
2010 Mathematics Subject Classification. 92D30, 92D25, 92C42, 34C60.
Novel Meta-Heuristic-based Drone Squadron Optimization Fast Charging Strategy for Battery Packs in Electric Vehicles
Authors: Manas Munish , Dubey Rajesh Kumar , Yadav Ravish
Published: April 2023

Faster lithium-ion battery (LIB) charging is one of the factors that have increased public acceptance of electric vehicles (EVs), yet high-rate charging can cause permanent LIB system deterioration and safety issues, even if it is within physical limitations. Motivated by this, this study proposes a novel approach for achieving optimal fast charging of batteries by utilizing a drone squadron optimization (DSO) technique. The technique considers various factors, including battery capacity, temperature, voltage, and state-of-charge (SOC) to optimize the charging process. The proposed approach uses a hierarchical control framework that optimizes the charging schedule and considers the charging capabilities of individual batteries and the overall system constraints. Simulations were conducted to evaluate the performance of the proposed technique, and the results demonstrated that it can significantly reduce the charging time of batteries while improving their overall efficiency. The technique also ensures that the charging process is conducted within the recommended temperature and voltage ranges to avoid damage to the battery. The proposed DSO technique can be useful in various applications that rely on battery-powered devices, where fast charging times are essential for operational efficiency.
A modified Taylor diagram to improve the comparison of models
Authors: Ghorbani Mohammad Ali , Khatibi Rahman , Ruskeepää Heikki
Published: April 2023

The Taylor diagram is modified in this paper to offer a new model performance metric: the distance of the modelled results to observed statistics. Traditionally, the Taylor diagram is used to compare several models in terms of the shortest distance from the modelled results to the observation point based on visual locations of their RMSE and correlation coefficients. The modified Taylor diagram calculates the distances and shows them in an accompanying table to facilitate their discrimination even if the points are too close. The new metric is tested in a hydrological study of the relationship between evaporation and minimum temperature at a station in Australia. A stringent testcase is presented, in which 10 selected model performances are quite close but the new metric discriminates their performances and facilitates learning. The efficacy of the study provides a proof-of-concept for the new metric in hydrology and applies to any other data-driven models.
Molecular characterization of Porokeratosis in Tunisian patients with intraindividual and intrafamilial clinical heterogeneity
Authors: Mabrouk Haifa El , Li Dong-lin , Mokni Sana , Chouk Hamza , Ghariani Nadia , Bousoffara Lobna , Saad Ali , Denguiezli Mohamed , Has Cristina , H’mida Dorra
Published: April 2023

Background
Porokeratosis (PK) is a group of rare acquired or inherited clonal keratinization disorders characterized by annular or linear hyperkeratotic plaques with central atrophy and raised borders. Cornoid lamella is the common histological feature between PK forms. Genes of the mevalonate pathway are implicated in the pathogenesis of this pathology. To date, the exact underlying molecular mechanisms remain misunderstood.
Results
In this study, we investigated two unrelated Tunisian families with heterogeneous PK for whom we reported a clinical heterogeneity with a simultaneous presence of three clinical forms of PK in two individuals. We identified two PMVK variants, nonsense and synonymous, in affected individuals and unaffected relatives. We suggest that the PK profiles of our Tunisian patients result from the germline nonsense mutation c.412A > T (p.R138*) responsible for the haploinsufficiency of the PMVK protein via the degradation of the mutant mRNA by the nonsense-mediated mRNA decay (NMD) mechanism and d a second hit postzygotic mutation in skin lesions. We suggest that the synonymous variant c.147A > G (p.E49=) could be a genetic predisposition factor increasing the susceptibility to the second hit mutation in the PMVK gene or another gene.
Conclusion
We report the first molecular characterization of PK within the Tunisian and North African populations. Our findings support the common molecular background of different clinical subtypes of PK and the fact that they can be considered a single disorder.
An EOQ model for a two warehouse system with price and time dependent demand and instantaneous deterioration during COVID-19 pandemic
Authors: Das Dolagobinda , Samanta Gauranga Charan
Published: April 2023

This paper develops an inventory model considering a demand disruption and a linear price and time dependent demand. In this model, we analyze two possibilities and apply the FIFO dispatch policy. In the first scenario, the inventories of the owned warehouse (OW) get vacant after the lock-down relieves owing to a shorter lock-down duration, but in the second scenario, the inventories of the OW get vacant during the lock-down due to a longer lock-down duration. A two parametric Weibull distribution has been considered to mirror the real problems caused by deterioration. The study aims to minimize the total cost of a two-warehouse system during the lock-down time. Furthermore, sensitivity analysis was used to investigate the models' behavior. Taking into consideration actual conditions, this model might be useful in an emergency situation like the COVID-19 epidemic.
Causes of Excess Capacity in the Manufacturing Sector
Authors: Pal Samidh
Published: April 2023

This study delves into the origins of excess capacity by examining the reactions of capital, labor, and capital intensity. To achieve this, we have employed a novel three-layered production function model, estimating the elasticity of substitution between capital and labor as a nested layer, alongside capital intensity, for all industry groups. We have then selectively analyzed a few industry groups for comparative purposes, taking into account the current government policies and manufacturing plant realities. Ultimately, we recommend that policymakers address the issue of excess capacity by stimulating the expansion of manufacturing plants with cutting-edge machinery. Our findings and recommendations are intended to appeal to academics and policymakers alike.
JEL Code: L6, L5.
Liver-On-A-Chip Model: an Alternative to Animal Models-Development Challenges and Future Perspectives
Authors: Gulla Aiste , Leber Bettina , Butkutė Agnė , Stiegler Phillipp , Jurkšas Tomas , Baravykas Tomas , Kvietkauskas Mindaugas , Marcinkevičiūtė Kristina , Schemmer Peter , Strupas Kęstutis
Published: April 2023

Purpose: To create a fast, affordable, reproducible a liver-on-a chip platform as an alternative to animal models of liver diseases.
Methods: The platform was fabricated out of fused silica by using femtosecond laser microprocessing. A channel with integrated filters of micropillars was produced by Selective Laser Etching (SLE) technique. Nano gratings were inscribed inside the glass by using focused femtosecond laser radiation. Subsequently, liver cells were etched in 35% Potassium Hydroxide (KOH) at 90 ° C or Hydrofluoric acid. The contact between both plates was achieved by intense light radiation with an integrated filter. There were 700 fs duration pulses used for SLE and 200 fs for laser welding. The light was focused with a 20 x 0.45 NA objective for SLE and a 0.5 NA aspherical lens for laser welding. The human liver HCC cell line HepG2(GS) was employed for biocompatibility testing.
Results: The platform consists of one channel divided into three sub channels by micropillars: the central channel for cells and two side channels for cell medium. All channels have inlet and outlet reservoirs with the depth up to 200 μm, and width of central and side channels up to 200 and 400 μm, respectively. Additionally, the final size of micropillars was 55 x 36 μm with a gap of 14 μm in between.
Conclusion: Based on our previously published work, this study provides a step-by-step design and validates the concept of testing human liver cancer cells. In addition, it provides developmental advancements and drawbacks of liver-on-a-chip designs.
Systematic review of empiric studies on lockdowns, workplace closures, and other non- pharmaceutical interventions in non-healthcare workplaces during the initial year of the COVID-19 Pandemic: Benefits and selected unintended consequences
Authors: Ahmed Faruque , Shafer Livvy , Malla Pallavi , Hopkins Roderick , Moreland Sarah , Zviedrite Nicole , Uzicanin Amra
Published: April 2023

Background
We conducted a systematic review aimed to evaluate the effects of nonpharmaceutical interventions within non-healthcare workplaces and community-level workplace closures and lockdowns on COVID-19 outcomes in workers or the general community and on selected mental health and labor market outcomes.
Methods
The inclusion criteria included systematic reviews, randomized controlled trials, and non-randomized studies. The exclusion criteria included qualitative, and modeling studies. Electronic searches were conducted using MEDLINE, Embase, and other databases from January 1, 2020, through May 11, 2021. Risk of bias was assessed using the Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool. A qualitative synthesis was performed.
Results
A total of 60 studies met the inclusion criteria. There were 40 studies on COVID-19 outcomes, 15 on anxiety and depression symptoms, and five on unemployment and labor force participation. There was a paucity of studies on physical distancing, physical barriers, and symptom and temperature screening within workplaces. Workplace closures significantly reduced COVID-19 incidence or growth rate (five of seven studies) and reproduction number (three of four studies) in the general community. Lockdown significantly reduced COVID-19 incidence and case growth rate (22 of 23 studies), reproduction number (10 of 11 studies), and COVID-19 mortality and death growth rate (seven of seven studies) in the general community. Lockdown significantly increased depression symptoms (10 of 15 studies), but the effect on anxiety symptoms was inconsistent. Lockdown increased unemployment (five studies) and decreased labor force participation (three studies). The risk of bias for most of the studies on COVID-19 or labor market outcomes was moderate or serious. The risk of bias for the studies on anxiety or depression symptoms was serious or critical.
Conclusions
Empiric studies that assessed the effect of workplace closures and lockdowns suggest that these measures helped reduce the impact of COVID-19, albeit with notable secondary (unwanted) effects. There is a pronounced paucity of studies on the effect of interventions, including symptom and temperature screening as well as less disruptive nonpharmaceutical interventions such as physical distancing measures within still-open workplaces. Addressing the gaps in the evidence base would be important for informing future pandemic preparedness.
Systematic review registration number:
PROSPERO registration # CRD42020182660.
Phytochemicals and Antioxidant Activities of Red Oak, Red Coral and Butterhead
Authors: Nadechanok Jiangseubchatveera  , Charinrat Saechan  , Arpa Petchsomrit  , Tawikan Treeyaprasert  , Nattawut Leelakanok  , Chadaporn Prompanya
Published: April 2023

Lactuca sativa L. is an economically important vegetable that contains numerous phytochemicals. This study aimed to determine the phytochemicals in three lettuce cultivars (red oak, red coral, and butterhead) and assess their total phenolics, total flavonoids, and antioxidant activities. The dried leaves of each lettuce cultivar were macerated with hexane, ethyl acetate (EtOAc), and 95% ethanol (EtOH). Total phenolics, total flavonoids and antioxidant activities from the three solvent extracts were measured. The phytochemical screening showed that the leaves from the three lettuce cultivars contained flavonoids, hydrolyzable tannins, coumarins, steroids, and phenolic compounds. While the EtOAc fraction of the red coral lettuce showed the highest total phenolic content (9.747 ± 0.021 mg gallic acid equivalent/g) and the hexane fraction of the butterhead lettuce contained the highest flavonoids (7.065 ± 0.005 mg quercetin equivalent/g). In the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, the EtOAc fraction of the red coral lettuce had the highest antioxidant capacity with an IC50 of 0.277 ± 0.006 mg/mL, whereas, in the ABTS (2,2’-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid)) assay, the 95% EtOH of the red coral lettuce had the highest antioxidant capacity with an IC50 of 0.300 ± 0.002 mg/mL. All three lettuce cultivars contained high levels of phenolic content and flavonoids, which are the source of antioxidant activities. These lettuce cultivars, especially the red coral lettuce, are a potential source of natural antioxidants. Further research on the application of natural antioxidants is required to investigate the therapeutic or the neutraceutical implication of the lettuce cultivars.
Uncovering the Microbiota of Bagworm Metisa plana (Lepidoptera: Psychidae) in Oil Palm Plantations in Malaysia
Authors: Andrew Ting  , Cik Mohd Rizuan Zainal Abidin  , Noor Hisham Hamid  , Ghows Azzam  , Hasber Salim
Published: April 2023

Bagworm Metisa plana is one of the major pests in Malaysia’s oil palm plantation, with infestation resulting in huge economical loss. Currently, the microbial profile of the bagworm has yet to be study. Understanding the biology of the pest such as the bacterial community is crucial as bacteria associated with insects often provide benefits to the insect, giving the insect host a better chance of survival. Here, 16S amplicon sequencing was used to identify the bacteria community of M. plana. Additionally, two comparisons were made, the bacterial communities between two larval stages (early instar stage and late instar stage) from outbreak area; the bacterial communities of late instar stage larvae from non-outbreak between outbreak areas. From this study, it was found that the bacterial community of M. plana consisted of Proteobacteria, Actinobacteria, Bacterioidetes, Firmicutes and other minor phyla, with Proteobacteria being the most dominant phylum. Furthermore, bacterial genera of M. plana consisted of Pantoea, Curtobacterium, Pseudomonas, Massilia and other minor genera, with Pantoea being the most dominant. It was also found that the alpha and beta diversity in both comparisons were not significantly different. We present our data as a first insight towards the bacterial community of M. plana, paving a way towards understanding the biology of the bagworm M. plana.
Identification and Optimization of Indole-3-Acetic Acid Production of Endophytic Bacteria and Their Effects on Plant Growth
Authors: Saowapar Khianngam  , Pimjai Meetum  , Pantipa Na Chiangmai  , Somboon Tanasupawat
Published: April 2023

Indole-3-acetic acid (IAA) is one of the most physiologically active auxins produced by rhizobacteria and is potentially applied for agriculture. Two endophytic bacteria, VR2 and MG9, isolated from the root of Chrysopogon zizanioides (L.) collected at Cha-Am, and the leaf of Bruguiera cylindrica (L.) Blume collected from a mangrove forest at Ban Laem, Phetchaburi Province, Thailand, were taxonomic characterised based on their phenotypic characteristics and 16S rRNA gene analysis. Strain VR2 was closely related to Enterobacter hormaechei CIP 103441T (99.6% similarity), while strain MG9 was closely related to Bacillus aryabhattai B8W22T (99.9% similarity). Consequently, they were identified as Enterobacter hormaechei and Bacillus aryabhattai, respectively. The IAA production of VR2 and MG9 strains are determined and applied to rice seeds for their root and shoot germination. Strains VR2 and MG9 greatly produced a yield of IAA, 246.00 and 195.55 µg/mL in 1,000 µg/mL of L-tryptophan at pH 6 for 48 h. They showed no significant differences in IAA to root and shoot development. However, the bacterial IAA exhibited potential nearby synthetic IAA, which had a significant effect compared to the control. IAA produced from these two strains might preferably trim down the use of synthetic IAA and could contribute to sustainable agriculture.
2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens
Authors: Nur Amiera Syuhada Rozman  , Tong Woei Yenn  , Leong Chean Ring  , Syarifah Ab Rashid  , Tan Wen-Nee  , Jun Wei Lim
Published: April 2023

Microbial infection is a frequent complication of diabetic foot ulcers, with up to 82% of ulcers being infected at the initial stage of diabetes. Furthermore, the emergence of beta lactam resistant pathogens managed to eliminate the use of beta lactam antibiotics as a chemotherapeutic alternative. This further increases the amputation and mortality rate. Hence, the aim of this study is to evaluate antimicrobial efficacy of a ketone derivative 2-octylcyclopentanone against diabetic wound pathogens. The inhibitory activity of the compound was determined using disc diffusion and broth microdilution assay. Generally, 2-octylcyclopentanone showed broad-spectrum antimicrobial activity, particularly against beta lactam resistant pathogens. The compound showed comparably better antimicrobial activity than all reference antibiotics, including chloramphenicol, streptomycin, ampicillin and penicillin. In addition, the same compound also inhibits a clinically isolated Pseudonomas aeruginosa that was resistant to all reference antibiotics. The activity was microbicidal based on the low minimal lethality concentration recorded, particularly on MRSA, P. aeruginosa and Candida utilis. The killing efficiency of the compound was concentration dependent. During kill curve analysis, the inhibitory activity of 2-octylcyclopentanone was concentration and time-dependent. 99.9% of reduction of bacterial growth was observed. MRSA and P. aeruginosa, two significant diabetic wound infections, are totally inhibited by the molecule at a concentration of minimum lethality concentration. In short, 2-octylcyclopentanone exhibited significant inhibitory towards wide range of diabetic wound pathogens. Which is considered crucial since it will provide a safe and effective alternative treatment for diabetic ulcer infection.
Method Validation for the Analysis of Multiple Weight Loss Drugs in Dietary Supplement Materials by LC-MS/MS
Authors: Tran Kevin , Monroe Douglas , Song Fenhong , El-Demerdash Aref
Published: April 2023

A method validation is reported for the detection and quantification of multiple weight loss drugs in dietary supplement materials. The sample preparation was followed as described in LIB 4549 and the mass spectral measurements were accomplished using liquid chromatography tandem mass spectrometry with electrospray ionization. A method validation was performed at various fortification levels (250 and 1000 g/g) for all 11 drug compounds. The overall recoveries with standard deviation averaged 93.8 6.65% with the majority of individual recoveries in the range of 76% - 110%. The overall limits of quantification (LOQ) for analytes averaged at 10 ng/g. An overall indicator of linearity (R2) averaged at 0.9993 (0.0 250.0 ng/mL). The precision of five replicates of the 50 ng/mL level averaged at 98.4 0.41% with < 1%.https://doi.org/10.21423/jrs-v03n02p015 (DOI assigned 8/7/2019)
Direct Determination of Glyphosate, Glufosinate, and AMPA in milk by Liquid chromatography/tandem mass spectrometry
Authors: Chamkasem Narong , Morris Cynthia , Harmon Tiffany
Published: April 2023

A simple high-throughput liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed for the determination of glyphosate, aminomethylphosphonic acid (AMPA) and glufosinate in milk using a reversed-phase liquid chromatography column with weak anion/cation exchange stationary phase.  One milliliter of milk was shaken with three milliliters of water containing Na2EDTA and acetic acid for 10 minutes, to precipitate the protein content in the sample. After centrifugation, the supernatant was passed through an Oasis HLB SPE to retain suspended particulates and phospholipids. The sample was directly injected and analyzed in 6 min, with no sample concentration or derivatization steps. Two multiple reaction monitoring (MRM) channels were monitored in the method for each target compound to achieve true positive identification. Three internal standards corresponding to each analyte were used to counter matrix suppression effects. The linearity of the detector response was demonstrated in the range of 4 to 1000 ng/mL for each analyte, with a minimum coefficient of determination (R2) value of more than 0.995. Through the use of this internal standard calibration method, the average recovery for all analytes at 0.025, 0.1, 0.5, and 2 µg/g (n = 7) are between 84-111% with a relative standard deviation of less than 8%.https://doi.org/10.21423/jrs-v03n02p020 (DOI assigned 8/7/2019)
Photoemission "experiments" on holographic lattices
Authors: Herček Filip , Gecin Vladan , Čubrović Mihailo
Published: April 2023

We construct a 2D holographic ionic lattice with hyperscaling-violating infrared geometry and study single-electron spectral functions (“ARPES photoemission curves”) on this background. The spectra typically show a three-peak structure, where the central peak undergoes a crossover from a sharp but not Fermi-liquid-like quasiparticle to a wide incoherent maximum, and the broad side peaks resemble the Hubbard bands. These findings are partially explained by a perturbative near-horizon analysis of the bulk Dirac equation. Comparing the holographic Green functions in imaginary frequency with the Green functions of the Hubbard model obtained from quantum Monte Carlo, we find that the holographic model provides a very good fit to the Hubbard Green function. However, the information loss when transposing the holographic Green functions to imaginary frequencies implies that a deeper connection to Hubbard-like models remains questionable.
The Truth about the Global Financial Crisis
Authors: Masood Omar
Published: April 2023

Dr. Omar Masood is the Subject Leader Banking & Finance at the Royal Docks Business School of University of East London. His areas of expertise are banking, finance, and corporate financial management, and risk management, fund management, banking regulations, Islamic banking and international business. He authored a number of research papers, which have been published in international journals and conferences.
Local and global sensitivity analysis and its contributing factors in reference crop evapotranspiration
Authors: Yong Stephen Luo Sheng , Ng Jing Lin , Huang Yuk Feng , Ang Chun Kit , Mirzaei Majid , Ahmed Ali Najah
Published: April 2023

Sensitivity analysis (SA) intends to identify the key meteorological variables that affect the performance of reference crop evapotranspiration (ET0) models. It is of importance in assessing the variability of meteorological variables and ET0, especially in the face of increasing climate uncertainties. However, the surging of inconsistencies resulting from global changes in meteorological conditions due to climate change have impacted the ET0 model estimation in different regions, with detrimental effects on water resources and crop production. Therefore, efficient SA is necessary to evaluate the impact of changes in meteorological variables that influence ET0 model estimation. This mini review analyses the various SA methods applied in the field of ET0, based on a comprehensive and comparative analysis of existing SA methods from all around the world. The study discusses the advantages and disadvantages of each SA method, as well as the factors affecting the SA of ET0. The study also provides future prospects that may contribute to more solid and powerful analysis for ET0 model estimations and conclusions.
Spatial mapping of water spring potential using four data mining models
Authors: Al-Shabeeb Abdel Rahman , Hamdan Ibraheem , Al-Fugara A'kif , Al-Adamat Rida , Alrawashdeh Mohammed
Published: April 2023

Population growth and overexploitation of water resources pose ongoing pressure on groundwater resources. This study compares the capability of four data mining methods, namely, boosted regression tree (BRT), random forest (RF), multivariate adaptive regression spline (MARS), and support vector machine (SVM), for water spring potential mapping (WSPM) in Al Kark Governorate, east of the Dead Sea, Jordan. Overall, 200 spring locations and 13 predictor variables were considered for model building and validation. The four models were calibrated and trained on 70% of the spring locations (i.e., 140 locations) and their predictive accuracy was evaluated on the remaining 30% of the locations (i.e., 60 locations). The area under the receiver operating characteristic curve (AUROCC) was employed as the performance measure for the evaluation of the accuracy of the constructed models. Results of model accuracy assessment based on the AUROCC revealed that the performance of the RF model (AUROCC = 0.748) was better than that of any other model (AUROCC SVM = 0.732, AUROCC MARS = 0.727, and AUROCC BRT = 0.689).
Meslek Yüksekokulu Çocuk Gelişimi Bölümü Öğrencilerinin Geri Dönüşüme Yönelik Görüşleri
Authors: KOÇAK TUMER Bilge
Published: April 2023

Meslek yüksekokulunda öğrenim görmekte olan Çocuk Gelişimi bölümü öğrencilerinin geri dönüşüm farkındalıklarını ortaya koymak amacıyla yapılmış olan çalışmada betimsel alan çalışmalarından tarama modeli kullanılmıştır. Nitel ve nicel verilerin kullanıldığı araştırmanın çalışma grubunu Ankara ilinde yer alan devlet üniversitesinin meslek yüksekokulunda çocuk bakımı ve gençlik hizmetleri bölümü 1. (N=55) ve 2. (N=64) sınıfında öğrenim görmekte olan 119 öğrenci oluşturmaktadır. Çalışma grubu kolay ulaşılabilir örneklem metoduyla belirlenmiştir. Araştırmada veri toplama aracı olarak Dinler, Simsar ve Doğan (2020) tarafından geliştirilen “Geri Dönüşüm Farkındalık Bilgi Anketi” kullanılmıştır. Veriler 2021-2022 eğitim-öğretim yılının güz döneminde aralık ayında, çalışmaya katılmaya gönüllü olan yüksekokul öğrencilerden online ortamda toplanmıştır. Frekans ve yüzde dağılımları hesaplanan verilerin, betimsel ve içerik analizleri kodlama yöntemiyle yapılmıştır. Araştırmanın sonucunda çocuk gelişimi bölümü öğrencilerinin geri dönüşüm kavramı konusunda yeterli bilgiye sahip olurken, geri dönüşümün amacı ve faydaları konusundaki bilgilerinin yüzeysel olduğu belirlenmiştir. Katılımcılar günlük hayatta en çok kullandıkları geri dönüşüm malzemesinin kâğıt ve plastik olduğunu, benzer şekilde en çok geri dönüştürdükleri malzemenin de kağıt ve plastik olduğunu ifade etmişlerdir. Katılımcılar geri dönüşümün önündeki en büyük engeli bilgisizlik olarak görmekte, bilgisizlik için alınacak önlemin eğitim olası gerektiğini belirtmekte ve bu eğitimin okul öncesi dönemde başlaması gerektiğini ifade etmektedirler.
Características morfológicas e produtivas da soja influenciadas por doses de cloreto de potássio na linha de semeadura
Authors: Fernando Marcos Brignoli  , Gilmar Luiz Mumbach  , Douglas Luiz Grando  , Abelino Anacleto de Souza Junior  , André Gustavo Misfeld  , Alan Roberto Hamm  , Bruna Andrieli Shaffer  , Fernando Francisco Dillmann Pajara
Published: April 2023

Para melhorar o aproveitamento, o potássio (K) é aplicado preferencialmente no sulco de plantio, na semeadura. Em virtude do efeito salino do KCl, altas doses devem ser evitadas. A hipótese do presente trabalho é que doses de K acima do limite recomendado na linha de semeadura (80 kg ha-1 K2O) prejudicam o desenvolvimento da soja. O objetivo foi avaliar os atributos morfológicos e o rendimento da soja diante do aumento da dose de K2 O na linha de plantio. O estudo foi conduzido em um cambissolo no município de Rio do Sul (SC). O delineamento experimental utilizado foi de blocos casualizados, com quatro repetições. Os tratamentos corresponderam a doses de potássio e uma testemunha sem aplicação. Avaliaram-se a massa fresca e o número de vagens, a massa de grãos, a parte aérea e de raízes, a massa fresca de nódulos e a produtividade. Procedeu-se à análise de variância, e os efeitos significativos foram desdobrados por regressão (p<0,05). As doses de K2 O influenciaram de forma quadrática a maioria das características atribuídas à parte aérea e ao rendimento da cultura. No entanto o sistema radicular não foi influenciado. O rendimento máximo da cultura ocorreu para a dose de 26 kg ha-1 de K2O.
Registro de necrofagia em paca (Cuniculus paca)
Authors: Cleiton José Geuster  , Mario Arthur Favretto
Published: April 2023

Cuniculus paca (paca) é um grande roedor sul-americano, considerado essencialmente frugívoro e habitante de áreas florestais perto de cursos d’água. No presente estudo, foi realizado o registro de necrofagia, consumo de carniça, em duas datas diferentes por Cuniculus paca. Não foi encontrado na literatura nenhum registro anterior reportando esse comportamento, porém há registros em espécies próximas, do gênero Dasyprocta. Tais informações demonstram que a necrofagia pode ser mais comum entre grandes roedores sul-americanos do que previamente registrado.
Síndrome de Evans na evolução de doença autoimune:
Authors: Henrique nunes Samon , Dos Santos-Silva Marco Aurélio , André Vaz Ricardo
Published: April 2023

Lúpus Eritematoso Sistêmico (LES) é uma doença inflamatória crônica, sistêmica, de causa desconhecida e natureza autoimune. Decorre do desequilíbrio da atividade imunológica inata e adquirida por fatores genéticos, ambientais e hormonais. A Síndrome do Anticorpo Antifosfolipídeo (SAF) é a associação de trombose e / ou morbidade gestacional com anticorpos antifosfolípides (anticoagulante lúpico, anticorpos anticardiolipina e / ou anticorpos anti-β2 -glicoproteína-I). Síndrome de Evans é caracterizada pela destruição autoimune das hemácias e plaquetas levando ao aparecimento concomitante e sequencial de Púrpura Trombocitopênica Idiopática (PTI) e Anemia Hemolítica Autoimune (AHAI).  O presente objetiva identificar quais indícios apontam para LES ou SAF como causa da Síndrome de Evans em uma paciente assistida no Hospital Universitário de Vassouras (HUV). O estudo justifica-se pela necessidade de atualização desse tema de importante relevância médica, visto os poucos relatos na literatura a esse respeito. Paciente, 31 anos, sexo feminino, deu entrada no HUV com quadro de TVP/TEP. Evoluiu com AHAI e PTI (Síndrome de Evans), o que levou à investigação de estados pró-trombóticos. Considerando os critérios para LES e SAF, verificou-se que a paciente preenchia critérios diagnósticos para SAF (TVP/TEP + anticoagulante lúpico positivo), porém não preenchia critérios para LES, pois apresentava critérios laboratoriais (anemia hemolítica, trombocitopenia e anticorpo antifosfolipídeo positivo), porém não apresentava nenhum critério clínico. Conclui-se que a paciente apresentou SAF primária, e que esta foi a provável causa da Síndrome de Evans, já que não existem marcadores específicos para LES nesta situação.
Effect of Early Balloon Inflation of Balloon Guide Catheter in Mechanical
Thrombectomy for Large Vessel Occlusion
Authors: Yi Ho Jun , Kang Beom Mo , Shin Dong-Seong , Kim Bum-Tae
Published: April 2023

Objective:

A balloon guide catheter (BGC) is widely used in mechanical thrombectomy
(MT). However, the balloon inflation timing of BGC has not been clearly established. We evaluated
whether balloon inflation timing of BGC affects the results of MT.

Methods:

Patients who underwent MT with BGC for anterior circulation occlusion were enrolled.
Patients were dichotomized into early and late balloon inflation groups, according to the timing of
BGC inflation. Angiographic and clinical outcomes were compared between the two groups. Multivariable
analyses were performed to evaluate the predictive factors for first-pass reperfusion
(FPR) and successful reperfusion (SR).

Results:

Of 436 patients, the early balloon inflation group showed a shorter procedure time (21
min (11-37) vs. 29 min (14-46), p = 0.014), a higher rate of SR with aspiration only (64.0% vs.
55.4%, p = 0.016), a lower aspiration catheter delivery failure rate (11.1% vs. 19.4%, p = 0.005),
less frequent technique conversion (36.0% vs. 44.5%, p = 0.009), higher rate of FPR (58.2% vs.
50.2%, p = 0.011), and a lower rate of distal embolization (7.9% vs. 11.7%, P = 0.006), compared
to the late balloon inflation group. In multivariate analysis, early balloon inflation was an independent
predictor for FPR (odds ratio, OR 1.53, 95% confidence interval, CI 1.37–2.57; p = 0.011)
and SR (OR 1.26, 95% CI 1.18-1.64; p = 0.018).

Conclusion:

Early balloon inflation of BGC enables an effective procedure than late balloon inflation.
Early balloon inflation was associated with higher rates of FPR and SR.
A Review on Inhibitory Action of Tyrosine Kinase Inhibitors (TKI) by
Curbing the ATP-Tyrosine Kinase Interactions
Authors: Kumar Vanktesh , Kaur Navjot
Published: April 2023

According to the latest data, the cancer prevalence fraction has surged to the highest number. This is why cancer has become a prominent disease that must be seen as a serious issue. Inhibitory action and ideas become prominent and necessary because of the rising death incidence daily. The simplifying idea of inhibition of cancer is targeting the complex that forms between the tyrosine kinase and ATP, which ultimately provides a clear way. Tyrosine kinase is a proteinaceous enzyme responsible for various cellular events like cell development, growth, and division. But these functions are performed by the activated tyrosine kinase, and the activation occurs by phosphorylation using ATP. The transfer of the phosphate group from ATP to tyrosine is known as phosphorylation. The basic idea is to enhance the competitive inhibition of the ATP-Tyrosine complex is a promising target for treating cancer. Various molecules have a substantial effect on the above-said target. This review summarizes molecules currently in any drug development or clinical trial with the same effect. This review covers most inhibitory molecules from different categories, which either directly or indirectly inhibit the Tyrosin kinase-ATP complex by incorporating.
Huisartsgeneeskunde, in de lengte en de breedte
Authors: Scherpbier-de Haan Nynke
Published: April 2023

De huisarts staat onder druk. Er kan niet nog meer zorg bij de huisarts belanden. Je hoort zeggen: ‘de rek is er uit, het zal uit de lengte óf de breedte moeten komen’. Nynke Scherpbier zal illustreren dat juist én in de lengte én in de breedte krachtige kernwaarden besloten liggen die het mogelijk maken dat de huisarts een sleutelrol speelt in ons gezondheidszorg stelsel. In de lengte vinden we de tijd die het mogelijk maakt dat de huisarts continuïteit van zorg kan bieden aan de patiënt. Hoe hoger de continuïteit van zorg, hoe beter het is voor de gezondheid van de patiënt. Om dit te garanderen zullen we zorgvraag en zorgaanbod meer met elkaar in balans moeten brengen. De afdeling Eerstelijnsgeneeskunde en Langdurige Zorg in het UMCG draagt daar aan bij in onderzoek, onderwijs, opleiding en in de Academische Huisartsenpraktijk Groningen. In onderzoek bestuderen we hoe door bijvoorbeeld preventie en e-health de zorgvraag kan verminderen. Via onderwijs en opleiding werken we er hard aan om het aantal huisartsen te doen toenemen, bijvoorbeeld door meer aandacht voor huisartsgeneeskunde in het geneeskunde curriculum aan te brengen. De breedte staat voor samenhang en samenwerking in de zorg. De patiënt zou de zorg als een samenhangend muziekstuk moeten ervaren. Elke zorgprofessional heeft immers haar eigen stem, maar in het samenspel wordt het pas muziek als regels voor samenspel in acht worden genomen. De afdeling doet onderzoek naar nieuwe samenwerkingsvormen binnen de eerste lijn en met het ziekenhuis om de kwaliteit van zorg te verbeteren.
Het intersekse lichaam in Japanse prentkunst. De onthullende geschiedenis van futanari en henjõ nanshi
Authors: Splinter Asa
Published: April 2023

Hoe werd het intersekse lichaam verbeeld in premodern Japan? Wie maakten die verbeelding en welke rol spelen zij in hoe er vroeger - en nu - wordt gekeken naar gender, geslacht en seksualiteit? Een visuele analyse van shunga en shunpon verklaart de rol van makers met een penis in het verafschuwen, bespotten of erotiseren van intersekse lichamen.
Slachtoffers van onwetendheid. Gebrekkige kennisverspreiding over het DES-hormoon in België sinds 1971
Authors: Van Kerckhove Antje
Published: April 2023

Tussen de jaren 1940 en 1970 maakte het DES-hormoon, dat werd toegediend aan zwangere vrouwen om miskramen te voorkomen, wereldwijd miljoenen slachtoffers. Toch blijft het DES-probleem in België tot op heden onder de radar. Aan de hand van interviews met DES-slachtoffers en artsen toont Antje Van Kerckhove aan hoe die onwetendheid verklaard kan worden.
PERBANDINGAN EFEKTIVITAS BANK SAMPAH DI KOTA BANDUNG DAN KOTA YOGYAKARTA
Authors: Agphin Ramadhan M.
Published: April 2023

ABSTRACTWaste is a problem that occurs in almost all major cities in Indonesia. Waste management could not beaddressed optimally both by society and the local government. Bank of waste is one of the media community inapplying the principles of the 3R (Reduce, Reuse, Recycle) which is expected to reduce waste in theenvironment. However, how the effectiveness of the waste bank. This study will present a comparison of theeffectiveness of waste bank in Bandung and Yogyakarta (Case Study Citizens Bank Manglayang Waste andWaste Bank ASRI which can later be used as a lesson for waste banks that have operational or will beestablished.Keywords: Bandung, community, Yogyakarta, waste bankABSTRAKSampah merupakan masalah yang terjadi di hampir semua kota besar di Indonesia. Pengelolaan sampah belumbisa diatasi secara maksimal baik oleh masyarakat maupun Pemerintah Daerah setempat. Bank sampahmerupakan salah satu media masyarakat dalam menerapkan prinsip 3R (reduce, reuse, recycle) yang diharapkandapat mengurangi sampah di lingkungan sekitar. Namun, bagaimana keefektifitasan bank sampah. Penelitian iniakan menyajikan perbandingan efektivitas bank sampah di Kota Bandung dan Yogyakarta (Studi Kasus BankSampah Wargi Manglayang dan Bank Sampah ASRI yang nantinya dapat dijadikan pelajaran bagi bank sampahyang telah beroperasional maupun yang akan berdiri.Kata kunci: Bandung, Bank Sampah, Masyarakat, Yogyakarta