bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of Gaussian spatio-temporal data with stationary separable covariances
Authors: Karaliutė Marta , Dučinskas Kęstutis
Published: March 2021

The novel approach to classification of spatio-temporal data based on Bayes discriminant functions is developed. We focus on the problem of supervised classifying of the spatiotemporal Gaussian random field (GRF) observation into one of two classes specified by different drift parameters, separable nonlinear covariance functions and nonstationary label field. The performance of proposed classification rule is validated by the values of local Bayes and empirical error rates realized by leave one out procedure. A simulation study for spatial covariance functions belonging to powered-exponential family and temporal covariance functions of AR(1) models is carried out. The influence of the values of spatial and temporal covariance parameters to error rates for several label field models are studied. The results showed that the proposed classification methodology can be applied successfully in  practice with small error rates and can be a useful tool for discriminant analysis of spatio-temporal data.
THE ITALIAN-STYLE AL FRESCO PAINTING THE RESURRECTION OF CHRIST IN I. S. TURGENEV’S FATHERS AND CHILDREN
Authors: Karpenko Gennady
Published: March 2021

The article focuses on the unsolved mystery of the novel by I. S. Turgenev Fathers and Children — the Italian-style al fresco painting The Resurrection of Christ, located above the entrance to the church at the entrance to the Odintsova estate. None of the researchers and commentators of Turgenev’s novel were puzzled by the question: what does “Italian-style” mean in the Easter image? Meanwhile, Turgenev directly points out that, instead of the gateway Orthodox icon, there is a religious painting The Resurrection of Christ (al fresco painting) in the church, where both the sacrament itself and the outsider witness (“a swarthy warrior in a spiked helmet in the foreground”) are presented. In the Orthodox Easter iconography, however, an outside figure is an unacceptable detail, and the sacrament of the Resurrection as the highest sacred reality in accordance with the spirit and letter of the Gospel was not depicted. The Easter sacrament was replaced by the scene of the Descent into Hell, but such an icon was still called Resurrection. Meanwhile, canonically, the procession of Christ is captured, when the Savior does not descend into hell, but rises from there on the icon of the Resurrection of Christ/Descent into Hell: he leads Adam and other biblical heroes out of the underworld by “grabbing of the wrist.” In this way, the Resurrection of Christ begins with the salvation of man, with co-resurrection. In the value and semantic space of the novel, the Orthodox icon of the Resurrection of Christ/Descent into Hell is concealed behind the “Italian” fresco-veil. If Turgenev knows the “Italian” semantics of the Resurrection, then it is quite natural that the author is more familiar with the semantics of the Orthodox icon from liturgical recollection and makes it covertly actual. The behind-the-scenes presence of the icon of the Resurrection of Christ/Descent into Hell and everything that is liturgically and theologically associated with it and experienced transubs the structure of Fathers and Children. The Easter hierotopy of the novel, outlined by the Orthodox icon and supported by the prayerful hopes of the finale 1) creates a very special, breathtaking and enlightening value space, correlated with eternity, the infinity of the spiritual, which affirms, elevating all present to endless life through participation; 2) sets up the supertext dimension, gives rise to the motive of transcendental hope: “You will not leave my soul in hell”; 3) and also strengthens the Russian word as the Christocentric foundation of Russian culture.
ANTHROPOLOGICAL PROBLEMS OF F. M. DOSTOEVSKY’S CREATIVITY
Authors: Shalina Marina
Published: March 2021

The article deals with the anthropological aspects of Dostoevsky’s creative work. Its study requires researchers to take into account the classic’s pronounced Christian orientation of the artistic system. In the center of this system is the ideal of Christ, in whose light Dostoevsky’s concept of man is formed and the typology of characters is determined. The dominant type is the hero-ideologist, however, in addition to the underground type, he is also represented by the heroes of the “positive idea”. The latter preach the idea of salvation through the transformation of the person in Christ, rather than the idea of forcibly changing the world to achieve universal happiness. However, Dostoevsky’s anthropological discovery was not only the idea of compassion for a person fallen in sin, but also the concept of human transience in earthly existence, and hence the assertion of the idea of immortality, in which man will achieve his fullness and harmony. The quintessence of Dostoevsky’s anthropological concept is the idea of “all-humanity” (“vsechelovechnost”) and “universal responsiveness”, capable of uniting people on the basis of spiritual brotherhood and acceptance of the alien as one’s own.
Encapsulation of cellular suspensions of lactic bacteria with silica
Authors:   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Krupska T. V. , Turov V. V. ,   Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Tsapko M. D. ,   Taras Shevchenko University Ukraine, Skubishevska-Zieba J. ,   Maria Curie-Skłodowska University Poland, Leboda L. ,   Maria Curie-Skłodowska University Poland
Published: March 2021

A promising direction for long-term storage of cells at relatively high temperatures may be their encapsulation with nanoscale biologically inert materials capable of creating a shell around microdroplets of a cell suspension, which, on the one hand, provides the possibility of gas exchange between the suspension and the external environment, and on the other hand, inhibits the processes of cell life, so transferring them to a state close to suspended animation. The method of low-temperature 1H NMR spectroscopy was used to study the process of hydration of lactobacilli, the effect of a weakly polar organic medium on it and the encapsulation of cells with silica. The aim of this work was to study the hydration of cell suspensions and the viability of lactic acid bacteria cells encapsulated with silica and the penetration possibility of such an active substance as trifluoroacetic acid into them. As a result of the studies carried out, it has been shown that the spectral parameters of water in concentrated cell suspensions of lactic acid bacteria strongly depend on the concentration of the suspension, which is probably associated with the possibility of the formation of a stable cell gel, which can be encapsulated by silica particles without its destruction in both air and a chloroform medium with addition of trifluoroacetic acid. The radial distribution curves of non-freezing water clusters have two maxima corresponding to R = 2 and 20–100 nm. The contribution to the distribution of the second maximum increases with increasing water concentration.
Use of Procalcitonin in a Febrile Infant Clinical Pathway and Impact on Infants Aged 29 to 60 Days
Authors: Widmer Kaitlin , Schmidt Sarah , Bakel Leigh Anne , Cookson Michael , Leonard Jan , Tyler Amy
Published: March 2021

OBJECTIVES:

Recent evidence suggests that measuring the procalcitonin level may improve identification of low-risk febrile infants who may not need intervention. We describe outcomes after the implementation of a febrile infant clinical pathway recommending measurement of the procalcitonin level for risk stratification.

METHODS:

In this single-center retrospective pre-post intervention study of febrile infants aged 29 to 60 days, we used interrupted time series analyses to evaluate outcomes of lumbar puncture (LP), antibiotic administration, hospital admission, and emergency department (ED) length of stay (LOS). A multivariable logistic regression was used to evaluate the odds of LP.

RESULTS:

Data were analyzed between January 2017 and December 2019 and included 740 participants. Procalcitonin use increased post–pathway implementation (PI). The proportion of low-risk infants receiving an LP decreased significantly post-PI (P = .001). In the adjusted interrupted time series analysis, there was no immediate level change (shift) post-PI for LP (0.98 [95% confidence interval (CI): 0.49–1.97]), antibiotics (1.17 [95% CI: 0.56–2.43]), admission (1.07 [95% CI: 0.59–1.96]), or ED LOS (1.08 [95% CI: 0.92–1.28]), and there was no slope change post-PI versus pre-PI for any measure (LP: 1.01 [95% CI: 0.94–1.08]; antibiotics: 1.00 [95% CI: 0.93–1.08]; admission: 1.03 [95% CI: 0.97–1.09]; ED LOS: 1.01 [95% CI: 0.99–1.02]). More patients were considered high risk, and fewer had incomplete laboratory test results post-PI (P < .001). There were no missed serious bacterial infections. A normal procalcitonin level significantly decreased the odds of LP (P < .001).

CONCLUSIONS:

Clinicians quickly adopted procalcitonin testing. Resource use for low-risk infants decreased; however, there was no change to resource use for the overall population because more infants underwent laboratory evaluation and were classified as high risk post-PI.
Mental Health Diagnoses and Seasonal Trends at a Pediatric Emergency Department and Hospital, 2015–2019
Authors: Marshall Rebecca , Ribbers Amanda , Sheridan David , Johnson Kyle P.
Published: March 2021

BACKGROUND:

Increasingly, youth with mental health disorders and suicidality are presenting to emergency departments (EDs) and requiring hospitalization. For youth with suicidality, studies reveal seasonal variations in frequency of presentations but do not identify associated diagnoses or whether other primary mental health complaints also reveal seasonal variations.

METHODS:

Data were collected between January 2015 and December 2019 by a child and adolescent psychiatry consultation-liaison service in a pediatric ED and hospital. Descriptive analysis and multiple linear regression were performed to assess volume over time, seasonal trends, and associated diagnoses.

RESULTS:

A total of 2367 patients were included, with an average age of 13.9 years and female predominance (62.3%). During the study period, annual ED consultations increased 87.5% and hospital consultations increased 27.5%. Consultations revealed seasonal trends, with highest volumes during January, April, May, October, and November (P < .001; adjusted R2 = 0.59). The most frequent diagnostic categories were depressive disorders and trauma- or stressor-related disorders. Thirty-six percent of patients presented after a suicide attempt, with the highest rates in spring (P = .03; adjusted R2 = 0.19). Boarding rates revealed significant seasonality, with higher instances in February, March, April, May, and October (P = .009; adjusted R2 = 0.32).

CONCLUSIONS:

Mental health presentations to a pediatric ED and hospital reveal seasonal trends, with the highest volumes in fall and spring and the most common diagnoses being depressive and trauma-related disorders. Suicide attempts are highest in late spring. Knowledge of these trends should inform hospitals, mental health services, and school systems regarding staffing, safety, surveillance, and prevention.
Pneumonia Severity in Children: Utility of Procalcitonin in Risk Stratification
Authors: Sartori Laura F. , Zhu Yuwei , Grijalva Carlos G. , Ampofo Krow , Gesteland Per , Johnson Jakobi , McHenry Rendie , Arnold Donald H. , Pavia Andrew T. , Edwards Kathryn M. , Williams Derek J.
Published: March 2021

OBJECTIVES:

To determine if serum procalcitonin, an indicator of bacterial etiology in pneumonia in all ages and a predictor of severe pneumonia in adults, is associated with disease severity in children with community-acquired pneumonia.

METHODS:

We prospectively enrolled children 2 months to <18 years with clinical and radiographic pneumonia at 2 children’s hospitals (2014–2019). Procalcitonin samples were obtained at presentation. An ordinal outcome scale of pneumonia severity was defined: very severe (intubation, shock, or death), severe (intensive care admission without very severe features and/or high-flow nasal cannula), moderate (hospitalization without severe or very severe features), and mild (discharge). Hospital length of stay (LOS) was also examined. Ordinal logistic regression was used to model associations between procalcitonin and outcomes. We estimated adjusted odds ratios (aORs) for a variety of cut points of procalcitonin ranging from 0.25 to 3.5 ng/mL.

RESULTS:

The study included 488 children with pneumonia; 30 (6%) were classified as very severe, 106 (22%) as severe, 327 (67%) as moderate, and 25 (5%) as mild. Median procalcitonin in the very severe group was 5.06 (interquartile range [IQR] 0.90–16.83), 0.38 (IQR 0.11–2.11) in the severe group, 0.29 (IQR 0.09–1.90) in the moderate group, and 0.21 (IQR 0.12–1.2) in the mild group. Increasing procalcitonin was associated with increasing severity (range of aORs: 1.03–1.25) and increased LOS (range of aORs: 1.04–1.36). All comparisons were statistically significant.

CONCLUSIONS:

Higher procalcitonin was associated with increased severity and LOS. Procalcitonin may be useful in helping clinicians evaluate pneumonia severity.
Effects of a Poetry Intervention on Emotional Wellbeing in Hospitalized Pediatric Patients
Authors: Delamerced Anna , Panicker Cia , Monteiro Kristina , Chung Erica Y.
Published: March 2021

BACKGROUND AND OBJECTIVES:

The hospital is often a challenging and unfamiliar environment for families. Hospitalization can increase stress and anxiety among children and caregivers. In this study, we are the first to explore the possible therapeutic effects of poetry on hospitalized pediatric patients’ emotional wellbeing.

PATIENTS AND METHODS:

Patients aged 8 to 17 years old admitted to the inpatient pediatric ward and their parents or guardians were eligible for inclusion. With the validated Pediatric Quality of Life Present Functioning Visual Analogue Scales, 6 items were measured before and after the poetry intervention for each participant: fear, sadness, anger, worry, fatigue, and pain in the present moment. The intervention itself consisted of poetry-based reading and writing exercises. Participants and parents also completed an open-ended qualitative survey on their experience.

RESULTS:

Data from 44 participants were analyzed. Using the Wilcoxon signed rank test, we showed that the poetry intervention had a statistically significant reduction in 5 of the 6 Pediatric Quality of Life Present Functioning Visual Analogue Scales symptom measures: fear (P = .021), sadness (P = .004), anger (P = .039), worry (P = .041), and fatigue (P < .001). Reduction in pain was not statistically significant (P = .092). Six coded themes emerged from qualitative analysis: the poetry intervention facilitated (1) happiness and (2) family involvement, was viewed as a (3) good distraction and (4) screenless activity, and cultivated (5) creativity and (6) self-reflection.

CONCLUSIONS:

The poetry intervention led to statistically significant reductions in fear, sadness, anger, worry, and fatigue but not in pain. The study reveals promising results and serves as a starting point for future investigations on the therapeutic impact of poetry on hospitalized pediatric patients.
Experimental study for improving behavior of castellated steel beam using steel rings
Authors: Al-Thabhawee Hayder Wafi , Al-Hassan Abbas Ali
Published: March 2021

Castellated beams are made from a hot rolled steel I-section in a few steps. Firstly, the web of the parent I-section is cut in a particular zigzag pattern and the two halves are reconnected by welding to form a castellated beam with hexagonal openings. In other cases, a spacer plate is placed between the two halves to produce octagonal openings, which increase the section depth. Increasing the depth by adding spacer plates leads to web-post buckling. This study focuses on improving the castellated beam to obtain high strength with relatively low cost by placing a steel ring inside the octagonal openings to strengthen the weakest part, which is its web. The results show that the steel ring is effective in strengthening the web-post.
Behavior of concrete beams internally cured with clay brick waste
Authors: Rasheed Laith Sh. , Ridha Mahmmod Laith Mohammed , Alaa Abed Alameer Sara , Thamer Abdulrasool Abdulrasool
Published: March 2021

In this research, the long-term potential cracking of normal concrete internally cured with clay brick waste as a sustainable approach was investigated. 10% and 15% volume of sand was substituted with corresponding quantity of pre-saturated clay brick waste to enhance the hydration of cement and improve properties of concrete. Four beams internally cured were compared with two control beams. The use of clay brick waste can improve the compressive and splitting tensile strength and also a significant reduction in cracks were observed. Depending on the recorded results, it is demonstrated that the exemplary percentages of clay brick waste to natural fine aggregate was found to be 15%, which developed greatest compressive and splitting tensile strength, and reduce the crack by means of flexural test.
THE INFLUENCING FACTORS OF OPENING OF COLLEGE SPORTS RESOURCES IN THE BACKGROUND OF NATIONAL PUBLIC FITNESS SERVICES
Authors: Chen Xuan , Hu Biao , Wang Lijun , Tian Fujun
Published: March 2021

ABSTRACT There are some problems such as few and old equipment in urban community sports fitness facilities, which makes it difficult for community fitness resources to continue to meet the fitness needs of community residents. The opening of university sports resources can alleviate the problem of residents' fitness difficulty to a certain extent. In order to explore the problems faced by the opening of university sports resources, this study established the analytic hierarchy process model based on the analytic hierarchy process (AHP) and Delphi law in the background of national public service of fitness, and combined with the questionnaire survey method to study the influencing factors of opening of college sports. The model modified by the Delphi method contains 6 first-level and 22 second-level influencing factors. It is found that the most important factor in the first level is the hardware factor of college sports resources, and the most important factor of the second level is the spatial layout of university sports resources. The results show that improving the hardware facilities of university sports resources, improving the management mode of sports resources, and increasing the targeted financial subsidies and tax reduction and exemption are helpful to enhance the willingness to open sports resources and improve the quality of opened sports resources. It is hoped that this study can promote the opening of college sports resources and promote the continuous improvement of the service level of sports resources.
STUDY ON THE HEALTH AND SELF-EFFICACY OF PREGNANT WOMEN IN DELIVERY WITH MUSIC ANALGESIA AND LABOR DOULA
Authors: Feng Fan
Published: March 2021

ABSTRACT To explore the effect of delivery supported by a labor doula combined with music therapy on stabilizing maternal psychology and improving delivery quality, and to find out the predictors of delivery self-efficacy. Statistical processing showed that P<0.05, which was statistically significant. Group was superior in numerical value, followed by the B group. Using the rank sum test, the pain grade of the experimental group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). T test or χ2 test showed that the total labor time of the experimental group was shorter than that of the control group. Vaginal delivery rate was higher than that of the control group, and the cesarean section rate was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Doula delivery combined with music therapy is effective in parturient delivery, which can alleviate parturient pain, speed up labor progress and improve delivery quality, and is worthy of popularization and application. At the same time, increasing pregnant women’s understanding of delivery strategies and techniques and improving their psychological state will help improve the level of delivery self-efficacy of pregnant women.
RESEARCH ON THE APPLICATION OF MUSIC-BASED PSYCHOLOGICAL ADJUSTMENT IN IMPROVING POSTGRADUATES’ MENTAL HEALTH
Authors: Yin Zhuoran
Published: March 2021

ABSTRACT At present, the mental health problem of postgraduates is still in the highest position, which directly affects the level of intellectual performance in social work. While mastering professional knowledge, it also requires postgraduates to have higher ideological and psychological qualities. On the basis of domestic and foreign research, this study takes the concept and advantages of music-based psychological adjustment as a theoretical basis and, through a large number of questionnaires, combined with the psychological characteristics of science and engineering postgraduates, we use the comparative method, the statistical analysis method and the experimental method to study the influence of music-based psychological adjustment on the mental health level of science and engineering postgraduates. It further illustrates that music promotes communication between man and nature. Music promotes communication between people and society. Music promotes communication between people and their inner world. Music can also build people’s faith and find the home of the soul. It emphasizes the influence of music on postgraduates’ emotions. The purpose of this is to build a reasonable and perfect music therapy system, so as to further enrich and strengthen the connotation and effect of mental health education in colleges and universities.
THE RELATIONSHIP BETWEEN PUBLIC AND PRIVATE HEALTH INVESTMENT AND ECONOMIC DEVELOPMENT BASED ON THE OVERLAPPING GENERATIONS (OLG) MODEL
Authors: Jiang Shuihui
Published: March 2021

ABSTRACT As an important part of human capital, healthy human capital plays a great role in promoting economic development. Based on the overlapping generations (OLG) model, this study establishes a correlation analysis model between healthy human capital and economic growth. This model takes utility maximization as the theoretical carrier to study how individuals promote economic growth while pursuing the maximization of their own health capital accumulation. The model can analyze the promotion mechanism of healthy human capital on economic growth, so as to provide decision support for relevant personnel. Taking the panel data of 11 provinces and cities in China as samples, this paper makes an empirical analysis of the model. The results show that healthy human capital investment in coastal areas is generally high, and the relationship between healthy human capital and economic growth conforms to the inverted U-shaped development model, so we should pay attention to the reasonable proportion of healthy human capital investment. In addition, from the fitting effect of the regression model, the F-statistic values of model 1 and model 2 are 672.6327 and 1240.188, which shows that the fitting accuracy of the two regression models is higher.
THE EVALUATION OF STUDENTS’ PHYSICAL HEALTH BASED ON THE INTEGRATION OF FAMILY AND SCHOOL PHYSICAL EDUCATION
Authors: Huang Yanchun
Published: March 2021

ABSTRACT In recent years, China has paid more and more attention to students’ physical health, but it is difficult for schools to provide scientific guarantee for students’ physical health evaluation. How to use scientific algorithm for accurate guidance has become the current hotspot. Based on this, this paper studies the evaluation model of students’ physical health based on the integration of home and school sports. Firstly, this paper analyzes the research status of physical health evaluation at home and outside, then optimizes and improves the deficiencies in the integration of home and school sports in the current research hotspot, then applies SVM algorithm to the physical health evaluation model. Finally, the experimental results show that the SVM algorithm can objectively evaluate the integration of home and school sports, and can optimize the evaluation strategy according to the differences of students in the process of physical exercise, and the accuracy of physical health evaluation can reach more than 97%.
Estimation of potential groundwater recharge by a drywell in sandy clay soil
Authors: Justino Eliane Aparecida , Failache Moisés Furtado , Barbassa Ademir Paceli
Published: March 2021

ABSTRACT We estimated the potential groundwater recharge (Rpot) of a drywell that receives, temporarily stores, and infiltrates direct surface runoff from a contribution area (180.5 m2) comprising a roof and a cemented floor. The Rpot for traditional rainwater management and for similar contribution area but covered with grass was also estimated for comparison. Our methodology involved the use of water budget equation, monitoring of rainfall and soil water content up to 1.92 m depth, estimation of drywell overflow using the modified Puls model, and determination of actual evapotranspiration using water stress coefficient in 2017 and 2018. Results revealed that the Rpot for drywell was 83.3% of the precipitated volume, 2.22 times higher than that of the grass-covered area (37.6%) given the increased area for evapotranspiration in the latter. In turn, the traditional urban drainage system did not demonstrate potential of groundwater recharge. Therefore, the drywell contributes significantly to groundwater recharge apart from serving as local flood control.
Profilaxia pós-exposição ao HIV em populações vulneráveis: estudo longitudinal retrospectivo em um ambulatório da rede pública do Rio Grande do Sul, 2015-2018
Authors: Castoldi Luciana , Berengan Marina Marques , Both Nalu Silvana , Fortes Vanessa Schmidt , Pinheiro Tanara Vogel
Published: March 2021

Resumo Objetivo: Descrever o perfil de usuários que iniciaram a profilaxia pós-exposição ao HIV (PEP) em um serviço público, avaliando o uso dessa tecnologia pelas populações-chave recomendadas pelo Ministério da Saúde do Brasil. Métodos: Estudo longitudinal retrospectivo, com uso de dados secundários de usuários atendidos entre 2015 e 2018. Foram calculadas frequências absolutas e relativas e o teste do qui-quadrado de Pearson foi utilizado para comparar características comportamentais. Resultados: Dos 270 usuários, foram mais frequentes adultos jovens (45,4%), homens (74,7%), raça/cor da pele branca (76,3%), alta escolaridade (65,7%) e múltiplas parcerias sexuais (40,7%). Entre as populações-chave, observou-se maior frequência de usuários de álcool e/ou outras drogas (49,6%) e homens que fazem sexo com homens (38,1%), enquanto pessoas transgênero (2,2%) e profissionais do sexo (4,8%) fizeram menor uso da PEP. Conclusão: O uso de PEP não foi homogêneo entre os grupos vulneráveis avaliados, com baixa frequência de pessoas transgênero e profissionais do sexo.
Intervenção com ivermectina para COVID-19 (SARS-Cov 2): sinopse baseada em evidências
Authors: Person Osmar Clayton , Puga Maria Eduarda dos Santos , Atallah Alvaro Nagib , Amaral José Luiz Gomes do
Published: March 2021

Contexto: A COVID-19 é uma doença viral que surgiu recentemente e associada à síndrome da angústia respiratória severa (SARS). Seu potencial de gravidade e impacto na saúde da população e economia global é objeto primordial na busca por uma terapêutica eficaz ea ivermectina tem sido recomendada para prevenção e tratamento da COVID-19. Objetivo: avaliar como evidências na literatura relativa ao uso de ivermectina para prevenção e tratamento de casos de COVID-19. Desenho de estudo: Trata-se de sinopse de evidências. Métodos:Procedeu-se à busca de bases eletrônicas de dados PubMed (1966-2021), EMBASE (1974-2021) e Clinical Trials (2021) e em dois megabuscadores de evidências: Turning Research Into Practice (TRIP) database (2021) e Epstemonikos ( 2021). Não houve restrição geográfica e de idioma, sendo utilizados descritores e termos do DeCS (Descritores em Ciências da Saúde). O método de síntese envolveu uma combinação de estudos semelhantes em uma revisão narrativa. Resultados: Foram identificados 527 citações e 5 estudos foram incluídos. Há poucos ensaios clínicos concluídos todos apresentam pequena. Discussão: A maioria dos estudos disponíveis na literatura respalda-se em respostas terapêuticas in vitroea recomendação para uso em humanos tem-se baseado nos achados desses estudos. A questão não pode ser respondida com os estudos atuais, sendo recomendada a realização de ensaios de qualidade. Conclusões: Não há suporte atualmente na literatura para uso da ivermectina na prevenção ou tratamento COVID-19.
The social humanism by Tadeusz Zieliński (1859–1944)
Authors: Kwiatek Aleksander
Published: March 2021

The aim of the article is to present the idea of social humanism by Tadeusz Zieliński, an outstanding classical philologist, thinker, creator of the phenomenon called Slavic Renaissance, being a professor at St. Petersburg University (until 1920) and Warsaw University, a doctor h. c. at many high schools in the country as well as abroad. He treated his humanism in different aspects, not just as a category strictly referring to the epoch of Renaissance, but also having alternated through history, in order to search a harmony between the one human being and the society. The proposals and projects that he declared within this context, placed him around the great defenders of the republican anthropocentrism which opposed the doctrinal liberalism.
Evaluation of communicative competence of experts in the field of education
Authors: Боднар Оксана
Published: March 2021

The article considers the content and specificity of the communication competences of an expert in the field of education. The subjective factors influencing the development of the expert's communication skills were identified. Its communication functions in the process of expertise are described, communication barriers and typical errors in providing information to the subjects are presented. On the basis of the developed criteria, a parametric-index model of evaluating an expert's communicative competences is constructed which it is possible to carry out selection experts for research on pedagogical objects.
Strategy of “Scaffolding” for teaching children with special educational needs
Authors: Плужник Оксана
Published: March 2021

The article explores one of the important teaching strategies for all children, especially children with special educational needs – scaffolding, which accelerates learning how to solve problems. This metaphor was suggested by an American psychologist, educator Jerome Bruner and his colleagues to describe the process of teaching a child in the zone of proximal development, according to the theory of L.S. Vygotsky. It has been clarified that scaffolding has much in common with differentiation, but these two approaches have some peculiarities. They can be combined to achieve goals better. In the process of research, considered the types of scaffolding, their features and strategies for practical application. As a result, tips were provided in the scope of successful use of scaffolding in the classroom.
Suicídio e sofrimento social no capitalismo: desemprego e expressões da questão social
Authors: Mangini Fernanda Nunes da Rosa , Nunes Igor Sastro
Published: March 2021

O suicídio é considerado um problema de saúde pública pela Organização Mundial da Saúde (OMS), mas pouco se estuda qual a ligação desse fenômeno complexo junto as expressões da questão social. Este trabalho tem como objetivo compreender a influência do capitalismo no adoecimento da classe trabalhadora e de que forma as expressões da questão social influenciam no desejo de morte do trabalhador. Tendo como resultados o entendimento de que as expressões da questão social produzidas pela sociedade capitalista têm forte influência no desejo de morte dos trabalhadores, sendo necessário além de respostas individuais, respostas coletivas de enfrentamento a essa demanda.
Perspectivas de adolescentes sobre a prática de cuidado dos irmãos: um estudo qualitativo
Authors: Koltermann Gabriella , Deus Meiridiane Domingues de , Santos Samara Silva dos
Published: March 2021

Este estudo buscou investigar as perspectivas de adolescentes sobre a prática de cuidado dos irmãos. A amostra foi composta por seis adolescentes de ambos os sexos, com idades entre 11 e 19 anos. As informações foram coletadas por meio de entrevistas semiestruturadas e as informações foram submetidas à análise de conteúdo. Ressalta-se a importância das atividades desempenhadas pelos adolescentes no contexto familiar para o sustento da família. A percepção do cuidador sobre o cuidado dispensado aos irmãos conteve aspectos positivos e negativos, sendo também considerada uma prática normal e rotineira. Dentre os pontos positivos, constatou-se transmitir algo de bom aos irmãos, os desafios e facilidades na realização de atividades de cuidado com os irmãos menores. A prática do cuidado pode contribuir para o sentimento de importância no contexto familiar, como também ser percebida como uma falha das mães no cumprimento de suas responsabilidades. As percepções negativas referiram-se à limitação dos tempos de lazer, à rotina estressante e à mediação de brigas entre os irmãos menores. Evidencia-se a importância de analisar o que essa prática representa para os adolescentes cuidadores, já que esta pode estar associada a sentimentos de desconforto, influenciar o bem-estar, bem como limitar a realização de atividades de lazer.
Focus on periodontal engineering by 3D printing technology – A systematic review
Authors:   Department of Preventive Dental Sciences, College of Dentistry, Gulf Medical University, United Arab., Reddy Manchala Sesha , Shetty Shishir Ram ,   Department of Oral and Craniofacial Health Sciences, College of Dental Medicine University of Sharjah, University City Sharjah, United Arab Emirates., Shetty Raghavendra Manjunath ,   Department of Clinical Sciences, College of Dentistry, Ajman University, UAE., Vannala Venkataramana ,   Department of Preventive Dental Sciences, College of Dentistry, Gulf Medical University, United Arab., Sk Shakeel ,   Department of Restorative Dental Sciences. College of Dentistry, Gulf Medical University, Ajman. United Arab Emirates., S Rajasekar ,   Department of Periodontics, Rajah Muthiah Dental College & Hospital, Annamalai Nagar, C. Kothangudi, India.
Published: March 2021

Three-dimensional (3D) bioprinting of cells is an emerging area of research but has not been explored yet in the context of periodontal tissue engineering. Objetive: This study reports on the optimization of the 3D bioprinting scaffolds and tissues used that could be applied clinically to seniors for the regenerative purpose to meet individual patient treatment needs. Material and Methods: We methodically explored the printability of various tissues (dentin pulp stem/progenitor cells, periodontal ligament stem/progenitor cells, alveolar bone stem/progenitor cells, advanced platelet-rich fibrin and injected platelet-rich fibrin) and scaffolds using 3D printers pertaining only to periodontal defects. The influence of different printing parameters with the help of scaffold to promote periodontal regeneration and to replace the lost structure has been evaluated. Results: This systematic evaluation enabled the selection of the most suited printing conditions for achieving high printing resolution, dimensional stability, and cell viability for 3D bioprinting of periodontal ligament cells. Conclusion: The optimized bioprinting system is the first step towards the reproducible manufacturing of cell laden, space maintaining scaffolds for the treatment of periodontal lesions.
Evaluation of Internal Bleaching with 35% Hydrogen Peroxide in Dentin Conditioned with 37% Phosphoric Acid and 17% EDTA
Authors:   Departamento de Endodoncia, Facultad de Odontología, Universidad Andres Bello. Quillota 980, Viña del Mar, Chile., Peña-Bengoa Fernando , Dufey Nicolás ,   Departamento de Endodoncia, Facultad de Odontología, Universidad Andres Bello. Quillota 980, Viña del Mar, Chile., Buchheister Germán ,   Departamento de Endodoncia, Facultad de Odontología, Universidad Andres Bello. Quillota 980, Viña del Mar, Chile.
Published: March 2021

Introduction: This study aimed to evaluate the effect of dentin surface treatment with 37% phosphoric acid or 17% ethylenedia-minetetraacetic acid (EDTA) before Internal Bleaching with 35% hydrogen peroxide using the walking bleach technique. Material and Methods: This experimental in vitro study used 66 human premolars extracted for orthodontic reasons, which were debrided, endodontically prepared, and pigmented with chromogens derived from blood decomposition. The samples were randomly divided into three groups (n=22). Group A: bleaching agent without dentin conditioning; group B: bleaching agent in dentin conditioned with phosphoric acid 37%; group C: bleaching agent in dentin conditioned with 17% EDTA. 4 applications of bleaching agent were used with a separation of 4 days between each session. The initial color (baseline) and after each application was determined by spectrophotometry, recording the CIE L*a*b* values and the total color variation between the initial parameters and the different evaluation times. Results: Data were statistically analyzed with the Wilcoxon test. This showed statistically significant differences for the total variation of the color between the study groups, with the control group in no case inferior to the rest. Conclusion: The application of 37% phosphoric acid increased the effectiveness of the bleaching agent when compared to 17% EDTA. However, these did not increase the effectiveness compared to the application of the bleaching agent without a previous dentin surface treatment.
Rehabilitation protocol after varization osteotomy - Case Study v1
Authors: Santos Sebastião
Published: March 2021

Background: Knee rehabilitation using therapeutic exercises in the aquatic environment has been used in order to initiate lower limb rehabilitation earlier and improve joint movements, as it reduces pain and allows for earlier weight bearing. Objective: To develop and describe the effects of an aquatic therapeutic exercise program in a case study of tibial osteotomy and varus femur. Methods: A 15-year-old girl undergoing a tibial and femoral varus osteotomy completed an aquatic therapeutic exercise program consisting of a total of 30 sessions (3 sessions per week of 60 minutes). The subject was evaluated at two different times (at the beginning and end of the intervention). Results: There was an improvement in the various parameters evaluated (knee flexion: 66º vs 125º; knee extension: -7º vs -1º; pain on movement: 6/10 vs 0/10). Conclusion: The aquatic therapeutic exercise program used in this study has beneficial effects in a clinical case of tibial osteotomy and varus femur.
Dundee peripheral blood mononuclear cell (PBMC) isolation protocol (from whole blood) v1
Authors: R. Sarhan Adil
Published: March 2021

We describe a fast and efficient peripheral blood mononuclear cell (PBMC) isolation for LRRK2 kinase pathway analysis Gain of kinase function mutations in the Leucine rich repeat kinase 2 (LRRK2) are associated with causing Parkinson’s disease. LRRK2 phosphorylates a subgroup of Rab GTPases and their phosphorylation levels mirror LRRK2 kinase activation status. Here, we describe a facile and robust method for isolating PBMCs by facilitated density gradient centrifugation, subsequent treatment with and without the specific LRRK2 kinase inhibitor MLi-2 to ensure that any effect seen is LRRK2 kinase dependent and cell lysis. PBMC lysates can then be used to quantify LRRK2 kinase pathway activity by measuring LRRK2-mediated phosphorylation of its endogenous RabGTPase substrates in human peripheral blood neutrophils either by quantitative immunoblotting or targeted mass-spectrometry. The benefits of using PBMCs are that they are routinely used as a biomatrix for Parkinson’s research and their isolation procedure is significantly faster and easier than that for example of neutrophils or monocytes from peripheral blood. However, their heterogeneity in terms of cellular composition and highly variable expression levels of LRRK2 and its substrates including Rab10 make PBMC a suboptimal biomatrix for reliably measuring LRRK2 kinase pathway activity. A potential use could be target engagement studies in clinical trials targeting LRRK2.
PENGARUH KECEMASAN KARIR TERHADAP COMMITMENT TO CAREER CHOICE DENGAN KELEKATAN ORANG TUA SEBAGAI MODERATOR
Authors: Mirah Fenesha Flourencia Effraim , Indianti Wahyu
Published: March 2021

The purpose of this study was to examine the moderating role of parental attachment towards the effect of career anxiety on Commitment to Career Choice. Commitment to Career Choice is a position in individual career development that includes certainty about one’s career choice, a positive sense of vocational future and awareness of potential obstacles (Blustein, Ellis, Devenis, 1989). This study focus on one dimension of Commitment to Career Choice, tendency to foreclose. Tendency to foreclose is the desire to commit to one career decision as soon as possible without any period of exploration. This study used quantitative approach, involving 315 high school student as participants. The results indicated that there is significant effect of career anxiety on tendency to foreclose with parental attachment as a moderating variable. This study concludes with implication and suggestions for future research.
NEED TO BELONG DAN OF MISSING OUT MAHASISWA PENGGUNA MEDIA SOSIAL INSTAGRAM
Authors: Shodiq Fajar , Kosasih Engkos , Maslihah Sri
Published: March 2021

This research  is to find the correlation between need to belong and fear of missing out in college instagram user in Bandung city. Quantitative research method used in this research with participant of 324 college student in Bandung city. The instrument in this research was using need to belong and fear of missing out scale made by Wibowo and Santika that adapted from the aspects of need to belong and fear of missing out by Baumeister and Leary for the need to belong scale, and Pryzblzski, Murayama, DeHaan, and Gladwell for measuring fear of missing out. This research made data analysis simple correlation. Result showed that there is positive correlation between need to belong and fear of missing out with adjustment of 0.327.
PENGARUH SAFETY CULTURE DAN SAFETY LEADERSHIP TERHADAP PERCEIVED MORAL INTENISTY PADA KARYAWAN PRODUKSI DI SEKTOR INDUSTRI ENERGI
Authors: Lovina Desty , Riyanti Benedicta P Dwi , Benedictus Ratri Atmoko
Published: March 2021

Kecelakaan kerja merupakan sebuah permasalahan yang krusial bagi setiap perusahaan khususnya bidang industri energi. Lokasi penelitian adalah perusahaan energi yang memiliki permasalahan terkait pelanggaran dan kecelakaan kerja. Sebanyak 60% karyawan dari 344 karyawan melakukan pelanggaran dan 12 kecelakaan telah terjadi dari tahun 2017 sampai dengan 2019. Permasalahan sulitnya meminimalisir kecelakaan kerja dan pelanggaran dikarenakan safety culture yang belum matang dan tidak adanya keteladanan dari leader yang dapat dicontoh sehingga berdampak pada proses pengambilan keputusan etis yang dilakukan karyawan. Untuk itu, peneliti melakukan penelitian pengaruh Safety Culture dan Safety Leadership terhadap Perceived Moral Intensity. Penelitian ini merupakan penelitian kuantitatif dengan analisis regresi ganda. Partisipan penelitian ini terdiri dari 90 karyawan. Hasilnya, terdapat pengaruh Safety Culture terhadap Perceived Moral Intensity, dan Safety Leadership tidak berpengaruh terhadap Perceived Moral Intensity. Peneliti merekomendasikan rancangan intervensi berupa sosialisasi mengenai budaya safety yang telah divalidasi oleh user.
Sağlıklı Genç Erkeklerde Farklı Egzersiz Modalitelerinin El Bilek Eklem Hareket Açıklığı ve El Kavrama Gücüne Etkisi
Authors: KELEŞ Nurullah , KOCA Tuba Tülay
Published: March 2021

Giriş: Egzersiz reçetesi genellikle, belirli bir amaç için tasarlanmış, genellikle sağlıklı veya hasta kişi için bir uzman tarafından geliştirilen özel aktiviteler planını ifade eder. Farklı egzersiz modalitelerinin sağlıklı bireyler üzerindeki faydalarına ilişkin önemli veriler mevcuttur. Burada sağlıklı genç erkeklerde farklı egzersiz modalitelerinin el bilek hareket açıklığına (EHA) ve kavrama gücüne etkisini araştırdık. Egzersizlerin birbirleriyle üstünlüklerini karşılaştırdık.

Materyal ve Metod: Çalışma prospektif, deneysel olarak planlandı. Veriler anket yolu ile aynı deneyimli hekim tarafından toplandı. Katılımcılar Kahramanmaraş Sütçü İmam Üniversitesi Fiziksel Tıp ve Rehabilitasyon polikliniğine başvuran sağlıklı gönüllülerden oluşturuldu. Çalışmamıza 20-30 yaşları arasında sağlıklı 50 erkek dahil edildi. Katılımcılar rastgele 5 farklı egzersiz grubuna ayrılmıştır. Grup 1: izometrik egzersiz (n=10); grup 2: aktif egzersiz (n=10); grup 3: dirençli egzersiz (n=10); grup 4: pasif germe egzersiz (n=10); grup 5: teraband ile egzersiz (n=10). Tüm hastalara 2 dakika ara ile 5 setlik, 10 tekrar şeklinde el bilek ekstensör ve fleksör kas gruplarına farklı egzersiz modaliteleri uygulandı.

Bulgular: Çalışmaya 20-29 yaş aralığında ortalama 24.4±2.5 yıl yaşlarında; vücut kitle indeksi (VKİ) ortalaması 24.4±3.3 kg/m2 olan 50 sağlıklı erkek dahil edildi. Her grupta 10’ar kişi olacak şekilde egzersiz grupları belirlendi. Tüm egzersiz gruplarında EHA farkı egzersiz sonrası artarken; el kavrama gücünün değişmeği veya azaldığı görülmektedir. EHA artış değerleri izometrik egzersiz grubunda (median=3.5 derece), takiben teraband egzersiz grubunda (median=4 derece), aktif egzersiz grubu (median=0.5 derece), pasif germe (median=1.5 derece) ve dirençli egzersiz grubunda (median=1.5 derece) idi (p=0.002). El kavrama güçleri farkı karşılaştırıldığında gruplar arasında anlamlı fark bulunmadı (p=0.735). Tüm grupta el kavrama gücü, el bilek EHA ile yaş, VKİ korele bulunmadı.

Sonuç: Tüm egzersiz modaliteleri akut dönemde el bilek EHA artırmakta ve kavrama gücünde ise genel olarak azalmaya sebeb olmaktadır. El bilek EHA farkındaki artış en fazla izometrik egzersiz grubunda iken; en az aktif egzersiz grubunda bulundu. Farklı egzersiz modalitelerinin el kavrama gücüne etkisi açısından beş grubun sonuçları benzerdi.
Optimization of a screw conveyor's exploitation parameters
Authors: Karwat Bolesław , Rubacha Piotr , Stańczyk Emil
Published: March 2021

The paper describes the problem of designing screw conveyors in terms of determining their
exploitation characteristics. Based on the actual values of mass efficiency and power demand obtained in a laboratory experiment, the theoretical design methods and the numerical
discrete element method model results were verified. The obtained results have shown that
the currently used theoretical methods underestimate the mass efficiency and power demand
compared to experiments when typical values of filling rate coefficient and progress resistance coefficient are used. It was also shown that the results of DEM simulations are in good
agreement with the experiments in terms of mass efficiency and power demand. Based on
the exploitation characteristics determined in DEM simulations for different constructions
of the screw and different rotational speeds, multi-objective optimization of the exploitation
parameters of the screw was performed in order to minimize the power demand of a screw
conveyor and simultaneously maximize its mass efficiency. The optimization results showed
that it is possible to find such construction and the rotational speed that will maximize the
mass efficiency of the conveyor and keep the power demand low, reducing the exploitation
costs of the device.