bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of different abutment materials on peri-implant tissue health and esthetics in fixed prosthodontics
Authors:   Department of Prosthodontics & Crown and Bridge, The Oxford Dental College, Bengaluru, Karnataka, India, Savitha PN , Solanki Swati , Soni Mukesh ,   Department of Prosthodontics & Crown and Bridge, Government College of Dentistry, Indore, Madhya Pradesh, India, Razdan Rahul Anand ,   Department of Prosthodontics & Crown and Bridge, Index Institute of Dental Science, Indore, Madhya Pradesh, India, Gupta Alka ,   Department of Prosthodontics & Crown and Bridge, Government College of Dentistry, Indore, Madhya Pradesh, India, Patel Khushali Nitin ,   Department of Prosthodontics & Crown and Bridge, AMC Dental College and Hospital, Ahmedabad, Gujarat, India
Published: February 2025

The choice of abutment material plays a critical role in peri-implant tissue health and the esthetic outcome of fixed prosthodontics. Various materials, such as titanium, zirconia, and gold alloy, offer different mechanical and biological interactions with the peri-implant tissues, influencing clinical outcomes. However, the long-term impact of these materials on peri-implant soft tissue response and esthetic appearance remains debated. A randomized controlled trial was conducted involving 90 patients requiring single-tooth implant-supported prostheses. Patients were divided into three groups, with 30 participants each receiving abutments made of titanium, zirconia, or gold alloy. Clinical parameters such as probing depth, bleeding on probing, plaque index, and peri-implant soft tissue thickness were recorded over 12 months. Esthetic outcomes were assessed using the pink esthetic score (PES) and white esthetic score (WES). After 12 months, titanium abutments exhibited a mean probing depth of 2.2 ± 0.4 mm, with a bleeding on probing (BOP) percentage of 25%. Zirconia abutments showed significantly lower peri-implant inflammation with a probing depth of 1.9 ± 0.3 mm and BOP of 10%. Gold alloy abutments demonstrated intermediate values with a probing depth of 2.1 ± 0.3 mm and BOP of 15%. Esthetic evaluation revealed that zirconia abutments provided the highest PES/WES score (mean PES = 12.5 ± 1.1, WES = 13.2 ± 1.0), followed by gold alloy (PES = 11.8 ± 1.2, WES = 12.5 ± 1.3), and titanium (PES = 11.2 ± 1.4, WES = 11.8 ± 1.5). Zirconia abutments offer superior peri-implant soft tissue health and esthetics compared to titanium and gold alloy abutments. Clinicians should consider zirconia as the material of choice for optimal biological and esthetic outcomes in fixed prosthodontics. However, further long-term studies are needed to validate these findings.
Prediction of pre-eclampsia using gestosis score
Authors:   Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India, Kharodia Shamimah Ayazahmed , Kshirsagar Nitin S. , Patil Supriya ,   Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India
Published: February 2025

Pre-eclampsia (P-EP) is a hypertensive pregnancy (HPT-PG) condition that develops after 20 weeks of gestation, with or without proteinuria, and is differentiated by vasospasm and vascular endothelial dysfunction. As a result, it is important to evaluate and predict P-EP using gestosis score (GT-S). We examined 229 pregnant patients at five prenatal visits and P-EP, using the Hypertensive Disease of Pregnancy (HDP) GT-S calculator app and a questionnaire that included 27 risk variables. We discovered a strong association between increased GT-S and the development of P-EP. As a result, GT-S is a reliable predictor of P-EP.
Side effects of oxytocin and carbetocin for mangement at third trimester
Authors:   Department of Obstetrics and Gynaecology, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India, Bahekar Akshay Anup , Patange Rajkumar P , Patil Yamini ,   Department of Obstetrics and Gynaecology, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India
Published: February 2025

The third stage of labor lasts from the time the baby is born until the maternal placenta is delivered. As a result, it is important to evaluate the effectiveness and side effects of oxytocin and carbetocin for third-trimester labor management. We divided 95 patients into two groups: group I received oxytocin and group II received carbetocin. We measured blood loss and duration at 72 hours and examined vitals and side effects after delivery. We discovered that there was no significant difference in side effects between the two groups (p value = 0.8). Although there was no difference, we concluded that carbetocin appeared to be a more effective alternative for minimizing blood loss in the third stage of labor.
Effect of conventional physiotherapy versus strain counter for trapezitis patients
Authors:   Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth (DU), Karad, Malkapur, Karad, Maharashtra, India, Desai Alok , Anandh S. ,   Department of Community Health, Krishna College of Physiotherapy, Krishna Vishwa Vidyapeeth (DU), Karad, Malkapur, Karad, Maharashtra, India, Mane Dhirajkumar ,   Statistician, Directorate of Research, Krishna Vishwa Vidyapeeth (DU), Karad, Malkapur, Karad, Maharashtra, India
Published: February 2025

On average 38.7% of the adult population experiences neck pain due to trapezitis (TPZ). Therefore, it is of interest to determine the efficacy of strain-counterstain (SCS) technique in treatment of TPZ. 40 participants were randomly allocated to two groups, where group 1 received conventional physiotherapy treatment, while Group 2 received the experimental SCS treatment program with 20 patients each. We found that, group 2 showed significant improvements in range of motion, pain, and neck disability outcome scores. We conclude that, (SCS) can be used as a low-cost and effective treatment for TPZ.
Evaluation of pre-analytical errors using six sigma metrics towards quality of laboratory performance in an Indian tertiary care hospital
Authors:   Department of Biochemistry, Shri Mata Vaishno Devi Institute of Medical Excellence and Associated Hospital, Shri Mata Vaishno Devi University, Kakryal, Katra, Jammu and Kashmir 182320, India, Seth Shruti ,   Laboratory Medicine, Shri Mata Vaishno Devi Narayana, Superspeciality Hospital, Kakryal, Katra, Jammu and Kashmir, 182320, India, Sah Narendra Kumar ,   Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Lado, Kumarhatti - Solan 173229 India, Rajwal Neha ,   Laboratory Medicine, Shri Mata Vaishno Devi Narayana, Superspeciality Hospital, Kakryal, Katra, Jammu and Kashmir, 182320, India
Published: February 2025

Six Sigma methodologies is one of the standard management system adopted to check the quality and improve laboratory performance continuously by assessing the laboratory process using six sigma metrics. A one-year prospective study from January 2019 to December 2019 was conducted in the laboratory medicine department of a tertiary care hospital. A total of 162974 samples were received from both inpatient and outpatient departments, and total laboratory errors were found to be 1144, with the maximum errors identified in the pre-analytical phase coming out to be 978 (0.6%). The types of errors in the pre-analytical phase after being identified and categorized were hemolyzed samples, clotted samples, phlebotomy errors, etc. The most typical error identified was clotted sample error (0.29%) followed by haemolysed sample error (0.20%). After calculating the error rate or defects per million error samples on a Sigma calculator, the value obtained was between 4 and 5, an average class quality. Our study concludes that continuous and repeated recognition of errors and evaluating them using Six Sigma metrics can help achieve overall laboratory procedure quality and better clinical diagnosis.
Evaluation of focal liver lesions using triple phase contrast computed tomography among Indian patients
Authors:   Department of Radiodiagnosis, Krishna Vishwa Vidyapeeth (Deemed to Be University), Karad, Maharashtra, India, Mittal Arjun , Kumbhar R. R ,   Department of Radiodiagnosis, Krishna Vishwa Vidyapeeth (Deemed to Be University), Karad, Maharashtra, India
Published: February 2025

Detecting and characterizing FLL remains a significant challenge in clinical practice. Therefore, it is of interest to evaluate the patients with FLL using TPC-CT. 80 patients spanned for around 18 months to correlate between CT scan findings & final diagnosis. We found male dominancy with high sensitivity for diagnosing hepatocellular carcinoma (HCC) at 73.7%, hemangioma’s at 94.1%, and metastases at 98.4%, whereas specificity for diagnosing all cases when the typical enhancement pattern for each lesion type was considered. We conclude that, tri-phasic CT can be widely accepted CT protocol used for assessing LL, allowing for the detection and characterization of most FL abnormalities (AB-N) across various pathological scenarios and stages of disease.
Gene expression analysis of Schizophrenia
Authors:   AIIMS Nagpur, India, Sharma Gunjan , Malik Ansh ,   AIIMS Nagpur, India, Tripathi Satyendra ,   Department of Biochemistry AIIMS Nagpur, India,   Bioinformatics Data Analysis Unit (BDAU), AIIMS, Nagpur, India, Deshmukh Vishwajit ,   Department of Anatomy AIIMS Nagpur, India,   Bioinformatics Data Analysis Unit (BDAU), AIIMS, Nagpur, India, Patil Ashlesh ,   Department of Physiology AIIMS Nagpur, India,   Bioinformatics Data Analysis Unit (BDAU), AIIMS, Nagpur, India
Published: February 2025

Schizophrenia is a chronic psychiatric disorder marked by cognitive deficits associated with prefrontal cortical dysfunction, particularly in Broadmann Area 10 (BA 10), where gray matter reduction is observed. The genetic mechanisms behind these abnormalities remain unclear. Therefore, it is of interest to analyze altered gene expression and pathways in the prefrontal cortex of schizophrenia patients. We used two GEO datasets - GSE12654 (discovery) and GSE17612 (validation) and differential gene expression was assessed between schizophrenia patients and healthy controls. Validation confirmed three upregulated genes (S100A9, S100A8, BCL2A1) and one downregulated gene (CBLB), with protein interaction analysis revealing that upregulated genes were linked to immune and apoptotic processes, while downregulated genes suppressed EGF pathways. These findings suggest immune dysfunction and gray matter loss in schizophrenia, highlighting potential biomarkers and therapeutic targets.
Therapeutic use of oral gastrografin in treating acute adhesive small bowel obstruction
Authors:   Department of Surgery, Chirayu Medical College & Hospital, Bhopal, India, Soni Sameer , Prakash Surya ,   General Surgery Unit, New Korba Superspeciality Hospital, Chhattisgarh, India, Rai Saurabh , Philips Sanish ,   Department of Surgery, Chirayu Medical College & Hospital, Bhopal, India
Published: February 2025

Adhesions are a major cause of small bowel obstruction, posing significant challenges in diagnosis, treatment and prevention. Adhesive small bowel obstruction has a substantial impact on morbidity and imposes a considerable socioeconomic burden. Therefore, it is of interest to study the therapeutic use of oral gastrografin in treating acute adhesive small bowel obstruction. Acute small bowel obstruction (SBO), accounting for 6-30% of cases. Adhesions are responsible for approximately 65-75% of SBO cases, necessitating careful assessment and management. This study, conducted at Chirayu Medical College & Hospital, Bhopal, India from June 2021 to May 2022, included 87 patients with 94 episodes of adhesive SBO. Initial conservative treatment resolved 63 episodes (67.02%) within 48 hours. The remaining 31 episodes (32.98%) were subjected to a Gastrografin challenge, where 23 cases (74.2%) showed successful dye transit to the colon within 24 hours, while 8 cases (25.8%) required surgical intervention. The findings suggest the Oral Gastrografin represents a significant advancement in the conservative management of acute adhesive small bowel obstruction, offering a non-invasive, effective and safe alternative to surgery for many patients. Its integration into clinical practice can enhance patient care and improve clinical outcomes in the management of ASBO.
Tumor biomarkers HE4 and CA125 alongside enhanced computed tomography imaging in assessing lymph node metastasis in endometrial cancer
Authors:   Department of Obstetrics & Gynaecology, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, India, Maurya Vandana , Singh Shruti , Singh Shubham ,   Department of Obstetrics & Gynaecology, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, India, Singh Shashi Prabha ,   Department of Biochemistry, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, India, Verma Manish Kumar ,   Department of Biochemistry, Rajashri Dashrath Autonomous State Medical College Ayodhya, U.P, India
Published: February 2025

The impact of HE4 and CA125 on lymph node metastasis in endometrial cancer and evaluate the diagnostic effectiveness of these biomarkers when combined with enhanced CT imaging to predict lymph node metastasis. The objective is to examine how HE4 and CA125 influence lymph node metastasis and to assess their diagnostic utility when paired with enhanced CT imaging to predict lymph node involvement in endometrial cancer. The study included 326 patients who underwent surgery for endometrial cancer (experimental group), alongside 98 individuals without cancer (control group). A retrospective analysis was carried out to assess the diagnostic efficacy of HE4 and CA125, in combination with enhanced CT, for predicting lymph node metastasis. Levels of HE4 and CA125 were measured and compared between the experimental and control groups, as well as within the lymph node-positive and negative groups. Significant variations in HE4 and CA125 levels were found between the endometrial cancer and control groups, and between lymph node-positive and -negative subgroups within the endometrial cancer cohort (p < 0.001). The AUC for HE4 was 0.73 (p < 0.001) in premenopausal and 0.578 (p = 0.164) in postmenopausal groups. For CA125, the AUC was 0.81 (p < 0.001) in premenopausal and 0.671 (p = 0.002) in postmenopausal groups. Cut-off concentrations to predict lymph node metastasis: Premenopausal - HE4 = 52.95 pmol/l, CA125 = 69.45 U/ml; Postmenopausal - HE4 = 69.15pmol/l, CA125 = 21.45 U/ml. Combining enhanced CT imaging with HE4 and CA125 improved diagnostic accuracy compared to individual tests. In conclusion, the study offers valuable insights into the potential usefulness of HE4 and CA125, in conjunction with enhanced CT imaging, for diagnosing and predicting lymph node metastasis in patients with endometrial cancer.
Management of haemorrhoids through siddha formulation Kuppaimeni samoola
Authors:   Department of Noi Naadal, National Institute of Siddha, Tambaram, Sanatorium, Chennai - 47, India, Gayatri R , Vinayak S ,   Siddha Central Research Institute (SCRI), Chennai, Tamil Nadu, India, Christian Gnanaraj Johnson , Hrudayakumari P. , Murugan Ramamurthy , Selladurai Elansekaran , Srinivasan V. , Paargavi A. Shakthi ,   Department of Noi Naadal, National Institute of Siddha, Tambaram, Sanatorium, Chennai - 47, India, Mohan Singh Saravanasingh Karan Chand ,   Department of Udal Koorugal, National Institute of Siddha Chennai, Tamil Nadu, India, Senthil Karthi ,   Department of Noi Naadal, National Institute of Siddha, Tambaram, Sanatorium, Chennai - 47, India
Published: February 2025

Hemorrhoids are a very common anorectal condition characterized by symptomatic enlargement and distal dislodgment of anal cushions which mainly affects the quality of life. Siddha herbal medicine Kuppaimeni (Acalypha Indica) is indicated for haemorrhoids, was used in this pilot study to catalogue the feasibility of Kuppaimeni samoola choornam in the management of first, second, and third- degree internal Hemorrhoids, along with a dietary regimen, of including two fig fruits in the daily diet. Ten participants were selected for the study and they underwent medication with a drug administration calendar period of forty – eight days. Prognosis was assessed by using Hemorrhoids Symptoms Severity (HSS) Scoring. The study findings of KSC are: among the ten cases, eight subjects got complete relief from symptoms after 48 days of medication. HSS scoring reduced to zero for all (8) first and second degree hemorrhoid cases and these 8 cases never had repeated episodes in follow-up time (5 years of follow-up after withdrawing medication). This study suggests the feasibility of using KSC in treating first and second-degree internal hemorrhoids.
Molecular docking analysis of breast cancer target RAC1B with ligands
Authors:   Institute of Sciences, SAGE University, Indore Madhya Pradesh, India 452020, Verma Kajal , Pillai Lakshmi ,   Institute of Sciences, SAGE University, Indore Madhya Pradesh, India 452020
Published: February 2025

Breast cancer is a malignant neoplasm that arises from the breast tissue, and the best chemotherapy preventive approach is to identify potent inhibitors. In this study, focusing on the Rac1b protein may be an effective approach to developing drug alternatives to treat breast cancer, and we have employed structure-based drug design with the available drugs. Afterwards, molecular docking was used to identify novel inhibitors, and in order to compute the drug likeness and medicinal chemistry, the best-docked complex was put through ADMET studies followed by molecular dynamics simulations to check the stability of the protein-ligand complex using RMSD, RMSF and protein-ligand interactions. Therefore, it is of interest to report the molecular docking analysis of breast cancer target RAC1B with ligands. Here, data shows that the therapeutic compounds that were evaluated showed greater stability in comparison to the reported compounds, EHop-016 and has found promising medication possibilities for breast cancer that target Rac1b.
Beta-hemolytic Streptococci in respiratory illness
Authors:   Department of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur- 603 203, Tamil Nadu, India, Gunasekaran Gayathri , Thirugnanam Dinesh Kumar ,   Department of Microbiology, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be university), Chennai, Tamil Nadu, India, Nalini Jayanthi N. ,   epartment of Respiratory Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur- 603 203, Tamil Nadu, India
Published: February 2025

Beta-hemolytic streptococci are associated with various respiratory illnesses, such as pharyngitis, scarlet fever, and pneumonia, highlighting the need for enhanced diagnostic, therapeutic, and preventive strategies. Advances in immunology and molecular biology have provided insights into the etiology and host immune responses to these infections, but many questions remain unanswered. Further research is needed to develop advanced diagnostics, explore vaccine candidates, understand immune responses, and address antibiotic resistance. Epidemiological studies are crucial to improving our understanding of these infections and their public health impact. A multidisciplinary approach integrating epidemiology, microbiology, immunology, and clinical medicine is essential to reduce the burden of beta-hemolytic streptococcal infections and improve overall treatment and prevention efforts.
Analysis of pH, electrolytes and non-invasive respiratory support in COPD with elevated CO2
Authors:   Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre, Hyderabad, India, Hussaini Madeeha , Minhaj Rida ,   Deccan college of Medical Sciences, Hyderabad, India, Aishwarya Nukala ,   Prathima Institute of Medical Sciences, Karimnagar, Telangana, India, Kurapati Maanasa ,   Kamineni Institute of Medical Sciences, Narketpally, Telangana, India, Al Khatib Yazan ,   Al Faisal University, Riyadh, Saudi Arabia, Yousuf Zehra ,   Deccan college of Medical Sciences, Hyderabad, India, Ibrahim Mohamed Mohamedelfatihmusaab ,   National Ribat University, Khartoum, Sudan, Azam Rabia ,   Quetta Institute of Medical Sciences, Quetta, Pakistan, Orfali Hamza A ,   Al Neelain University, Khartoum, Sudan, Abdul Mateen Mohammed ,   Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre, Hyderabad, India
Published: February 2025

The contributions of pH balance and electrolytes among patients with chronic obstructive pulmonary disease (COPD) experiencing hypercapnic exacerbations requiring non-invasive ventilation (NIV) are of interest. Hence, we used samples from 70 patients admitted in a tertiary care hospital from January to June 2023. The main variable analyzed was arterial blood gas data and serum electrolyte levels. A positive correlation between bicarbonate levels and PCO2 was found, with p < 0.01 and r = 0.74, indicating metabolic compensation for respiratory acidosis. NIV was required in the majority of patients: in 64.3%, values were higher for both PCO2 (52.3 ą 7.1 mmHg vs. 39.6 ą 4.3 mmHg) and bicarbonate levels (32.4 ą 4.8m Eq/L vs. 26.1 ą 3.1 m Eq/L; p < 0.01) in the NIV group. Thus, data highlights the role of monitoring PCO2 and bicarbonate in guiding the use of NIV and in a more secondary role to hypercapnia disturbances in electrolytes.
Evaluation of rapid detection methods for H5N1 virus using biosensors: An AI-based study
Authors:   Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Corso Europa 30, Genova - 16132, Italy, Eggenhöffner Roberto , Ghisellini Paola , Rando Cristina ,   Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Corso Europa 30, Genova - 16132, Italy, Papa Simonetta ,   Polistudium SRL, Milan, Italy, Khakshooy Allen ,   Department of Internal Medicine, Valley Hospital Medical Center, Las Vegas, NV - 89106, USA, Giacomelli Luca ,   Polistudium SRL, Milan, Italy
Published: February 2025

High mortality and zoonotic potential predispose the H5N1 avian influenza virus as a critical threat. Knowing that an epidemic could be occurring, quick and precise diagnostic techniques are essential for managing and containing possible epidemics. To detect H5N1 in saliva samples, this study investigates the theoretical design, simulation and evaluation of three kind of biosensors based on different technologies with potential as rapid identifications tools to diagnose quickly H5N1: Lateral Flow Tests (LFT), Field Effect transistors (FET) based electrochemical sensors and Quartz Crystal Microbalance (QCM) sensors. Through detailed AI-based simulations, we show the capabilities, sensitivities and specificities of these biosensors, highlighting their potential for applications in general biology as well as their suitability both for routine home practice and for applications by control entities in public settings. We therefore wish to pave the way to a framework for the quick creation of detection tools that can be swiftly implemented for rapid deployment in case of an outbreak of disease.
Carl Gustav Jung: Paradigms and extra-terrestrial intelligence
Authors:   Department of Internal Medicine, Morsani College of Medicine, Tampa, Florida 33606, USA, Shapshak Paul
Published: February 2025

Carl Gustav Jung (1875-1961) developed multiple paradigms across personal, social, and cultural domains. This report uses some of Jung's work across a broad context - the basis for possible communications with and among extra-terrestrial intelligences (ETIs). Jung’s domains, among many, include collective unconscious, archetypes, individuation, shadow, anima and animus, synchronicity, self, persona, complexes and psychological types. This paper hypothesizes the applicability of Jung’s paradigms and domains to communicate with ETI.
Integrating MICRORNA941 and T cell subset research into public health strategies for managing inflammaging in elderly and immune-compromised patients
Authors:   Dental Group of Sherman Oaks, Sherman Oaks, CA - 91403, USA, Fotovat Lily , Wang Kathleen ,   Dental Group of Sherman Oaks, Sherman Oaks, CA - 91403, USA, Chiappelli Francesco ,   Dental Group of Sherman Oaks, Sherman Oaks, CA - 91403, USA,   UCLA Center for the Health Sciences, Los Angeles, CA - 90095, USA
Published: February 2025

As of 2022, the Centers for Disease Control and Prevention (CDC) reported that the average life expectancy for both sexes in the United States is 77.5 years. While new advances in health have increased life expectancy, aging comes with complications that impact the development of diseases like cancer, senile dementia (non-Alzheimer), diabetes, and Parkinson’s. Through aging, the body’s immune system declines, a process recognized as immunosenescence, and which contributes to inflammaging, a state of chronic, though non-productive, inflammation that progresses with advancing age in the absence of overt infection and that contributes to the onset and progression of a spectrum of age-related pathologies. MicroRNAs are small forms of RNA that control gene expression by binding to messenger RNA (mRNA) in the cell cytoplasm. In particular, microRNA-941 (miR-941) has been found to play a critical role in the regulation of differentiation of cell populations, certain T cell subsets responsible for maintaining efficient immune surveillance in normal subjects, immune compromised individuals as well as the elderly. We propose that concerted research designed to define and characterize interventions targeting the regulatory effects of miRNA-941 specifically on T-cell subsets will benefit treatment of infectious (e.g., CoViD-19, H5N1 infection) and chronic illnesses (e.g., diabetes II, diabetes III, Long Covid [i.e., Post-Acute Covid-19 Syndrome, PACS], autoimmune disease), which are most common among the aging and the immune compromised population. It is possible and even probable that active research in this specific area will proffer new horizons for finding cures, aid in disease management and improved accessibility and affordability of public health services.
Awareness, perception and attitude towards nano dentistry among post-graduates from Rajasthan, India
Authors:   Department of Pediatric and Preventive Dentistry, Jaipur Dental College, Maharaj Vinayak Global University, Dhand amer, Jaipur, Rajasthan-302028, India, Kanodia Saloni , Khairwa Abhishek ,   Department of Pediatric and Preventive Dentistry, Jaipur Dental College, Maharaj Vinayak Global University, Dhand amer, Jaipur, Rajasthan-302028, India, Nanda Soumyaranjan ,   Department of Conservative Dentistry and Endodontics, SCB Dental College and Hospital, Cuttack, Odisha, India, Pareek Shubhangi ,   Department of Oral Pathology & Microbiology, SCB Dental College & Hospital, Cuttack, Odisha, Mishra Marium ,   Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India, Mohapatra Shreeyam ,   Department of Oral Medicine and Radiology, SCB Dental College & Hospital, Cuttack, Odisha, India, Surana Pratik ,   Department of Pedodontics and Preventive Dentistry, Maitri College of Dentistry and Research Centre, Durg, Chhattisgarh, India
Published: February 2025

Nano-dentistry utilizes nanoparticles and nano-materials to revolutionize dental treatments, offering enhanced precision, durability, and effectiveness in oral health care solutions. A survey of 290 postgraduate dental students in Rajasthan revealed that 93.4% were knowledgeable about nano-dentistry, with over 80% expressing positive views on its applications in eight key areas. These findings indicate a strong awareness and positive perception towards nanotechnology in dental care. The study highlights the growing interest and underscores the need to integrate nanotechnology into dental curricula to maximize its benefits for oral health care.
Innovations in denture marking: Forensic applications and clinical implications: A review
Authors:   Department of Prosthodontics & Implantology, AIMST University, Kedah, Malaysia, Jose Ajimol Theresa , Kaur Tejaspreet ,   Department of Conservative Dentistry and Endodontics , SKSS dental college, Sarabha, Ludhiana, India, Sarangi Sibani ,   Department of Periodontology, Hitech Dental College and Hospital, Bhubaneswar, India, Khan Sania ,   Department of Orthodontics & Dentofacial Orthopedics, District Bhoj Hospital, Dhar, Indore, Madhya Pradesh, India, Tripathi Shubham ,   Department of Conservative Dentistry and Endodontics, District Bhoj Hospital, Dhar, Indore, Madhya Pradesh, India, Chandrasekaran Sooriaprakas ,   Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (Deemed to be University) Chennai, Kashwani Ritik ,   Department of Oral Medicine and Radiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India
Published: February 2025

Denture marking is a vital tool in forensic odontology and clinical practice, aiding in the identification of dental prostheses, especially in disaster victim identification and cases where traditional methods fail. Techniques are categorized into surface methods like engraving and laser etching, and inclusion methods such as embedding RFID tags or barcodes. These markers provide reliable identification, assist in recovering lost prostheses, and can be implemented at low cost in routine dental practice. Advancements like RFID technology have made denture marking more efficient and reliable. Overall, denture marking enhances patient safety, reduces redundancy, and holds significant medico-legal value.
Effect of Bhastrika pranayama on neuro- cardiovascular-respiratory function among yoga practitioners
Authors:   Department of Physiology, AIIMS, Bhopal, India, Malhotra Varun , Javed Danish ,   Department of AYUSH, AIIMS, Bhopal, India, Pathak Tanusha ,   Department of Physiology, AIIMS, Bhopal, India
Published: February 2025

Bhastrika Pranayama, a vigorous yoga breathing technique, impacts both the autonomic nervous system and brain function. This prospective interventional study examined the acute effects of Bhastrika on heart rate variability (HRV) and electroencephalogram (EEG) patterns in 20 regular yoga practitioners. Significant increases in heart rate and sympathetic activity, as well as alterations in brain wave spectra, were observed during and after the practice indicated by a rise in low-frequency (LF) power and the LF/HF ratio, along with a decrease in high-frequency (HF) power and a substantial decrease in beta, theta, alpha and gamma waves while delta waves increased. The findings suggest Bhastrika enhances sympathetic activity and modifies cognitive states. Further research is necessary to understand its long-term benefits and therapeutic potential.
Role of emotional intelligence in shaping self esteem among Indian nurses at Trichy, Tamilnadu
Authors:   Department of Mental Health Nursing, KMC College of Nursing, Trichy, Tamilnadu, India, Rajathi A , Christena P ,   Department of Obstetrics and Gynecological Nursing, KMC College of Nursing, Trichy, Tamilnadu, India, Infantina J Rose ,   Department of Mental Health Nursing, KMC College of Nursing, Trichy, Tamilnadu, India, Catherine M Anitha ,   Department of Child Health Nursing, KMC College of Nursing, Trichy, Tamilnadu, India
Published: February 2025

Nursing is a multifaceted profession that requires a blend of technical skills and emotional intelligence (EI) to manage various responsibilities, from patient care to team supervision. EI is closely connected to self-esteem, a psychological construct representing an individual's self-worth and competence. Self-esteem significantly influences how nurses perceive their abilities and engage with their work environment. The current study adopted the non-experimental descriptive correlational survey design to assess the emotional intelligence and self-esteem among the nurses. The study was conducted for a period of two months, among 301 Nurses working in various departments of the hospital, Trichy, Tamilnadu. The assessment of the samples was done using the background variables, TEIQue-SF- (Trait Emotional Intelligence questionnaire- short form) and Rosenberg’s self-esteem scale. The data was collected through the Google Form for 4 weeks. The study results show that 81.1% of the nurses had average emotional intelligence only, 18.9% of the nurses had a high level of emotional intelligence and none of the nurses had a low level of emotional intelligence. In the aspects of self-esteem 76.4% of nurses had moderate level of self-esteem, 21.3% had high level of self-esteem and 2.3% had low level of self-esteem, there was a weak positive correlation between the level of Emotional intelligence and the level of Self- esteem with “r” value 0.321 & “p” value 0.01. Nurses render care to those who are emotionally heightened for patients and families. The persons exhibit confidence when they are emotionally intelligent, capable of understanding and stabilize their emotions. Self-esteem can be shaped by individuals’ relationships with others, experiences, and accomplishments in life.
Exploring root canal outcomes and periodontal disease in diabetic patients: A review
Authors:   Department of Preventive Dental Science, Faculty of Dentistry, Najran University, Najran, Saudi Arabia, Abdulrazzaq Abdo Mohammed Mohammed , Alyami Ali Mohammed ,   Dental intern, Faculty of Dentistry, Najran University, Najran, Saudi Arabia, Al Aqil Fayez Hamad , Al-khomsan Abdullah Mohammed , Al Hutaylah Sulaiman Mana , Al khamssan Hamad Mohammed , Alhammami Meshal Hussain ,   Dental intern, Faculty of Dentistry, Najran University, Najran, Saudi Arabia
Published: February 2025

This review of 14 studies (2000–2024) highlights a significant link between diabetes and poor root canal outcomes, emphasizing the need for specialized, evidence-based management to improve treatment efficacy in diabetic patients with periodontal diseases.
Prescribing trends and rational drug use patterns in cardiovascular patients: A cross-sectional observational study
Authors:   Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, India, Chikatipalli Radhika , Kuttiappan Anitha ,   SVKM’S NMIMS, School of Pharmacy and Technology Management, Shirpur, India, Kumar Sanjeev ,   Department of Pharmacology, People’s College of Medical Sciences & Research Centre, Bhopal, India, Vishali R. , Kujur Priyanka , Afsal N.A , Poojitha K.R ,   Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, India, Chenchula Santenna ,   Department of Pharmacology, All India Institute of Medical Sciences, Bhopal, India
Published: February 2025

Cardiovascular diseases (CVDs), encompassing conditions like coronary artery disease, hypertension, and ischemic heart disease, are highly prevalent worldwide. This study analyzed prescribing trends and treatment appropriateness in CVD patients, focusing on adherence to guidelines, essential medicine use, and generic drug prescriptions. A cross-sectional observational study was conducted on CVD-diagnosed patients. Data on prescribed medications—including drug classes, generic prescriptions, and adherence to the Essential Drug List (EDL)—were collected and analyzed using IBM SPSS version 26.0. The most frequently prescribed drug classes included antiplatelets, diuretics, and hypolipidemics. Aspirin was the most commonly prescribed medication (58.1%), followed by furosemide (36.5%), amlodipine (32.4%), and rosuvastatin (24.3%). Statins and calcium channel blockers were prescribed more often than angiotensin II receptor blockers and beta-blockers. On average, 13.2 drugs were prescribed per patient, with only 28.8% prescribed generically. Furthermore, 47.3% of medications were on the EDL. This study highlights the high prevalence of CVDs and the common drug classes prescribed to manage them. These findings provide important insights into current prescribing trends, particularly the frequent use of anti-hypertensive, antiplatelets, diuretics, and hypolipidemics, and suggest areas for optimizing medication management in this population. Additionally, there is a need to better manage polypharmacy in CVD patients.
Care and support for women during labour: A review
Authors:   Meenakshi Academy of Higher Education and Research, MAHER (DU) & NPME, College of Nursing, Madras Medical College, Chennai, India, Ramu Bama , Desigamani K. ,   Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER (DU), Enathur, Kanchipuram, Tamil Nadu, India, Rajendran Shankar Shanmugam ,   College of Nursing, Madras Medical College, Chennai. (The TN MGR Medical University, Chennai), India
Published: February 2025

The experience of childbirth significantly impacts a woman's mental, emotional and physical well-being requiring unique care varying throughout the process. The World Health Organization (WHO) emphasizes the importance of safe, effective, timely and woman-centred maternal and infant health care. Effective communication, respect and emotional support during labour are critical. However, unclear communication and mistreatment can lead to distress. Nonetheless, empathetic care enhances satisfaction during labour. Labour flexibility also contributes to comfort and control, underscoring the need for holistic, dignified and respectful maternal care. It should be noted that further research is essential to address postnatal care gaps and ensure women’s psychological and emotional needs are met globally.
In vitro anti-cancer activity of siddha metallo mineral formulation from Thanga uram with Hela cell lines
Authors:   Department of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India, Mohana Jeevanath Sathya Rathish , Venkatraman Manjari ,   Department of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India, Karuppan Kalaivanan ,   Department of Siddha Medicine, Government Primary Health Centre, Perungattur, Tiruvannamalai - 604402, Tamil Nadu, India, Balasubramani Abarna , Mohan Natarajan ,   Department of Nanju Maruthuvam, National Institute of Siddha, Dr.M.G.R Medical University, Chennai - 47, Tamil Nadu, India, Annamalai Siva ,   Department of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India) Kuyavarpalayam, Puducherry, India
Published: February 2025

The second most common malignant tumour in women worldwide, cervical cancer seriously jeopardizes their health. It has been established that a high-risk Human papillomavirus (HPV) infection is the cause of cervical cancer. Cervical cancer is associated with several risk factors, including reproductive, behavioural and sexual characteristics. Many Siddha practitioners often prescribe Thanga uram (TU), a Siddha metallo-mineral formulation, for genito-urinary diseases, infertility, varicose veins and leucorrhoea. This study aims to evaluate the anti-cancer activity of "Thanga uram" against HeLa cell lines. Hela cell lines were used to assess the antiproliferative activity TU using the MTT assay and apoptosis by Annexin V flow cytometry. Thanga uram produced dose dependent cytotoxic effects against HeLa cell lines with an LC50 value of 145.891痢/mL. Further investigation, using Annexin V flow cytometry, equivalently revealed the late apoptotic effect, with a percentage value of 28.15. Thus, the current study evaluates the effectiveness of Thanga Uram against cervical cancer.
A study on the effect of fibromyalgia severity on sleep quality using inflammatory markers
Authors:   Department of Physiology, AIIMS Bhopal, M.P, India, Singh Ruchi , Rai Jyotsana , Pathak Akash ,   Department of Physiology, AIIMS Bhopal, M.P, India, Rai Nirendra kumar ,   Department of Neurology, AIIMS Bhopal, M.P, India
Published: February 2025

Fibromyalgia syndrome (FMS) is a widespread musculoskeletal pain, often accompanied by fatigue and sleep disturbances. Poor sleep exacerbates inflammation and pain, potentially increasing levels of inflammatory markers. This study explored the effect of FMS severity on CRP levels, sleep quality and pain intensity. 89 FMS individuals were explored for FMS severity, pain and sleep quality. CRP levels in blood and erythrocyte sedimentation rate (ESR) were measured to assess inflammation. An increase in FMS severity was associated with an increase in CRP and ESR levels, pain intensity and sleep disturbances. However, a positive correlation between CRP levels and sleep quality indicates that Poor sleep quality in FMS may contribute to elevated CRP levels. Addressing sleep quality may mitigate the severity of FMS and its associated symptoms.
Effect of strip type denture adhesives on Candida species colonization in complete denture wearing patients
Authors:   Department of Prosthodontics and Crown & Bridge, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara - 391760, Gujarat, India, Chauhan Sameer , Prajapati Paranjay , Negi Pritha ,   Department of Prosthodontics and Crown & Bridge, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara - 391760, Gujarat, India
Published: February 2025

The present study was planned to evaluate the influence of strip of denture adhesive on oral microflora, mainly candida species in the participants who were instructed to use Super Polygrip Comfort Seal Strips denture adhesive for 14 days of trial period. 24 completely edentulous patients treated with complete denture were randomly divided into following - Control and Test group (12 each group). Test group was prescribed a strip denture adhesive and instructed to use it for 14 days. Samples of saliva were collected from all participants (both control and test groups) on 0 day, 7th and 14th day. Collected samples were diluted with standard protocol and coated on culture media of Sabouraud dextrose agar and incubated for 48 hours at 37○C. The CFU/ml was analyzed from both groups. Collected data then analyzed statistically with Mann - Whitney U - Test where α kept at ≤ 5%. No significant statistical difference was found between the control and the test group after the testing duration of 14 days. Thus, results suggested that strip denture adhesive did not have any influence on the colonization of candida species during 14 days of test period and it is safe for the use in complete denture wearing patients.
Effect of hypochlorous acid in open wound healing
Authors:   Department of Emergency medicine and critical care, Bliss Hospital, Murad Nagar Road, Mehidipatnam, Hyderabad - 500028, Telangana, India, Jalem Spurgeon raj , Usharani Purimitla ,   Department of Microbiology, Dr. Patnam Mahender Reddy Institute of Medical Sciences, Chevella, Ranga Reddy, Telangana, India
Published: February 2025

Wound healing is a complex process involving multiple stages to restore the integrity and function of damaged tissues. Researchers are exploring the therapeutic potential of HOCl in treating infections and inflammatory conditions, given its efficacy in killing pathogens and modulating immune responses. The present study is a prospective study aimed to know the wound healing nature of HOCl on open wounds in patients attending out-patient department. The study was conducted for a period of one year Jan 2023 to Jan 2024 at Bliss Hospital, Hyderabad, Telangana district, India. Hypochlorous acid (Vida solutions, Pvt.Ltd) was used to irrigate the open wound. Among the 10 reported cases, three were females and seven were males. Most of the cases were reported from middle age and old-age persons except one paediatric case of age 3 years a female girl. A male patient of age 72 years with co-morbidities diabetes and hypertension suffering with chronic wound on left leg for a period of 35 years because of thorn prick injury. The complete wound healing took nearly 15 weeks in this patient. The wound healing takes place 8 to 15 weeks maximum in all the 10 cases and the above findings concluded that, these features lead to a stabilized HOCl solution as an ideal wound care agent.
Analisis Implementasi Kebijakan Satu Data Indonesia (SDI) di Pemerintah Provinsi Banten
Authors: Irawan Syarrah , Handayani Riny
Published: February 2025

Presidential Regulation Number 39 of 2019 concerning One Data Indonesia aims to realize the availability of government data that is accurate, quality, up-to-date, and integrated with existing data, as well as easily accessible and shared between central and regional agencies.  This research focuses on the Analysis of the Implementation of the One Data Indonesia (SDI) Policy in the Banten Provincial Government. This study aims to find out and analyze how the implementation of the One Data Indonesia (SDI) policy in the Banten Provincial Government. The problem researched by the researcher is that human resources in the Banten Provincial Government are not enough in the implementation of the One Data Indonesia policy in the Banten Provincial Government. This study uses a qualitative method by analyzing the results of observations, interviews and documentation. The results of the study were analyzed using the policy implementation theory put forward by George C. Edward III which showed that the implementation of the One Data Indonesia (SDI) policy in the Banten Provincial Government has not been running well completely. In terms of resources, there are still insufficient human resources and there are no functional positions of statisticians in the Banten Provincial Government, and improvements are still needed in terms of facilities. In terms of bureaucratic structure, there is no Standard Operating Procedure (SOP) in the implementation of One Data Indonesia in the Banten Provincial Government and sanctions for data producers in the SDI implementation stage that do not yet exist.
Karakteristik Layanan Pencegahan Prevalensi Stunting di Bolaang Mongondow Timur
Authors: Posumah Johnny Hanny , Pombengi Jericho D. , Rorong Arie Junus
Published: February 2025

The stunting rate in East Bolaang Mongondow has increased quite significantly, reaching 346 cases or above 30%, second in North Sulawesi, so specific and sensitive interventions are needed from cross-sectoral Regional Work Units and problems found in the field. The phenomenon of stunting in school-age teenagers who marry too early, premarital sex for teenagers and unwanted pregnancies, then the lack of marriage guidance services for prospective brides and grooms by educating prospective brides and grooms to have an understanding and readiness to enter the world of marriage. as well as guidance services for family resilience to worship (sakinah). Additional food for toddlers is not optimal, the implementation of collaboration with the Village Government throughout Boltim in providing additional food (PMT) of animal protein given for three months is considered not optimal. The purpose of this study was to analyze the characteristics of stunting prevention services in East Bolaang Mongondow Regency. The expected results are that the prevalence of stunting in East Bolaang Mongondow Regency can reduce stunting cases.