bluuebunny/crossref_metadata_2025 huggingface dataset:
CAMPUR KODE PADA TAYANGAN YOUTUBE WAWANCARA NAJWA SHIHAB DENGAN MAUDY AYUNDA
Authors: Anggraini Nessa Aqila
Published: January 2023

Fenomenanya, saat ini makin banyak kanal youtube yang memuat konten wawancara dengan tuturan yang mencampurkan unsur bahasa lain ke dalam bahasa Indonesia. Tujuan penelitian ini adalah untuk mengidentifikasi tipe dan alasan terjadinya campur kode pada video youtube dengan konten wawancara Najwa Shihab dan Maudy Ayunda. Maudy Ayunda adalah sosok artis dan influencer muda yang sangat pintar serta memiliki image positif di kalangan generasi muda tanah air. Penelitian dilakukan dengan pendekatan analisis isi. Yang menjadi sumber data adalah tuturan Najwa Shihab dan Maudy Ayunda yang di dalamnya terjadi campur kode. Pengumpulan data dilakukan dengan analisis dokumen. Teori campur kode yang digunakan adalah teori Pieter Musyken (2000) dan Hoffmann (2014). Dari analisis data ditemukan 62 campur kode bahasa Inggris dalam bahasa Indonesia dan yang paling sering muncul adalah tipe alternasi (52%). Ada 5 dari 7 alasan campur kode yaitu membicarakan suatu topik, mengutip pernyataan, menunjukkan empati terhadap sesuatu, mengulang untuk klarifikasi, dan mengklarifikasi maksud mitra tutur. 
BAHASA GAUL DI KALANGAN REMAJA JAWA TENGAH (STUDI KASUS PADA PERCAKAPAN DI GRUP WHATSAPP)
Authors: Ramadaningrum Putri , Muryati Sri , Wicaksana Muhlis Fajar
Published: January 2023

Penelitian ini bertujuan untuk 1) mendeskripsikan bentuk bahasa gaul, 2) jenis makna bahasa gaul, 3) fungsi penggunaan kosakata bahasa gaul yang terdapat di dalam grup WhatsApp di kalangan remaja Sanggrahan Kecamatan Grogol Kabupaten Sukoharjo. Metode yang digunakan oleh penelitian ini adalah metode deskriptif kualitatif. Data dalam penelitian ini berupa wujud kosakata bahasa gaul, sumber data dalam penelitian ini adalah bentuk, makna, dan fungsi kosakata bahasa gaul pada grup WhatsApp. Teknik pengumpulan data menggunakan teknik dokumentasi yang digunakan berupa Screenshot (layar tembak) pada grup WhatsApp dan teknik catat yang dilakukan dengan mencatat data-data yang relevan. Teknik analisis data yang digunakan oleh penelitian ini adalah teknik distribusional. Dalam penelitian ini teknik yang digunakan dalam memperoleh bukti yang valid terhadap isi adalah teknik member checks. Hasil penelitian ini dapat disimpulkan bahwa Grup WhatsApp remaja Sanggrahan Kecamatan Grogol Kabupaten Sukoharjo dibuat pada tanggal 14 Agustus 2021 terdapat 7 kosakata bahasa gaul yang terbentuk melalui perubahan struktur fonologis dan 8 kosakata bahasa gaul yang mengalami proses pembentukan secara morfologis. Makna denotatif terdapat 4 kosakata bahasa gaul dan makna konotatif terdapat 2 kosakata bahasa gaul. Jenis fungsi penggunaan kosakata bahasa gaul yang terdapat dalam penelitian ini yaitu fungsi emotif yang terdiri dari 1 kosakata, fungsi konatif 1 kosakata, fungsi referensial 1 kosakata, dan fungsi fatik 1 kosakata.
HEGEMONI TANDINGAN DALAM NOVEL SEGALA YANG DIISAP LANGIT KARYA PINTO ANUGRAH
Authors: Baihaqi Juwita Wardah Maulidah
Published: January 2023

Hegemoni dapat terbentuk sebagai suatu sistem yang disepakati dan bersifat spontan dalam suatu kelompok masyarakat. Penelitian ini dilakukan dengan tujuan untuk mendeskripsikan hegemoni yang tercipta dalam dua kelompok masyarakat berdasarkan novel Segala yang Diisap Langit karya Pinto Anugrah. Novel tersebut membahas lokalitas dan masyarakat di kalangan suku Minangkabau. Kedua kelompok tersebut tercatat sebagai kelompok dominan dalam masyarakat Minangkabau. Dari penyataan tersebut, ditemukan dua bentuk kekuasaan yang yang mampu menimbulkan bentuk pertentangan, sehingga kajian ini juga berfokus pada hegemoni tandingan. Penelitian ini bersifat deskriptif kualitatif. Pendekatan yang dilakukan pada penelitian ini adalah pendekatan sosiologi sastra, khususnya berdasarkan teori hegemoni Gramscian. Metode yang dilakukan adalah studi Pustaka. Data dalam penelitian ini berdasarkan frasa dan kalimat dari narasi maupun dialog antartokoh. Data-data tersebut yang diperoleh dari novel Segala yang Diisap Langit karya Pinto Anugrah Hasil penelitian ini adalah (1) hegemoni terdapat pada dua kelompok, yakni kaum adat dan kaum agama; (2) Hegemoni tandingan terdapat pada kelompok masyarakat.
PENGARUH KONFLIK EKSTERNAL TERHADAP KEJIWAAN TOKOH SUMIKO DALAM NOVEL FREETER MEMBELI RUMAH KARYA ARIWAKA HIRO
Authors: Damayanti Atika Yuniar , Raharjo Resdianto Permata
Published: January 2023

Konflik sering kali menjadi pemicu terjadinya perubahan perilaku dan sikap. Dalam karya sastra pun, hal ini menjadi penyebab perubahan sikap pada suatu tokoh terutama pada psikologisnya. Peneliti merasa tertarik untuk mengungkap konflik eksternal yang menjadi faktor perubahan psikologis pada tokoh dalam suatu karya sastra. Penelitian ini bertujuan untuk mengetahui pengaruh konflik eksternal terhadap kejiwaan tokoh Sumiko dalam novel Freeter Membeli Rumah karya Ariwaka Hiro. Metode penelitian yang digunakan adalah deskriptif kualitatif yang dianalisis menggunakan teknik simak catat dalam pembacaan tertutup. Penelitian ini menggunakan teori psikologi sastra karena menelaah kejiwaan salah satu tokoh yang ada dalam karya sastra, khususnya pada novel Freeter Membeli Rumah karya Ariwaka Hiro. Hasil penelitian ini menunjukkan bahwa konflik eksternal memengaruhi kejiwaan tokoh Sumiko. Sumiko mengalami gangguan depresi akibat konflik eksternal yang dialaminya. Konflik eksternal tersebut adalah (1) anak Sumiko bernama Ayako yang mengerti masalah Sumiko pergi meninggalkan rumah setelah menikah, (2) anak Sumiko yang bernama Seiji tidak memiliki pekerjaan tetap dan senang bermalas-malasan, (3) suami Sumiko yang bernama Seiichi memiliki sifat temperamen dan hanya memedulikan diri sendiri, (4) perundungan oleh tetangga sekitar memperparah gangguan kejiwaan yang diderita Sumiko.
ANALISIS WACANA KRITIS OMNIBUS LAW DI MEDIA MASSA ONLINE SERTA PEMANFAATANNYA DALAM PEMBELAJARAN BAHASA INDONESIA DI SMA
Authors: Setyaningsih Dwi , Setiawan Budhi , Hastuti Sri
Published: January 2023

Penelitian ini dilatarbelakangi oleh permasalahan keberimbangan dan keberpihakan media, serta peralihan kurikululum 2013 ke kurikulum merdeka belajar. Itu membuat peneliti mengarahkan penelitian ini pada analisis struktur mikro, meso, dan makro teks. Kemudian hasil analisisnya direlevansikan dengan materi ajar artikel di Sekolah Menengah Atas (SMA). Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan representasi omnibus law di Suaramerdekasolo.com dan Solopos.com, proses penyajian berita, serta relevansinya sebagai materi ajar artikel berita di SMA. Metode yang digunakan adalah metode kualitatif paradigma kritis Analisis Wacana Kritis (AWK) Norman Fairclough dikombinasikan dengan analisis framing Pan dan Kosicki. Hasil penelitian ditemukan: 1) representasi omnibus law menunjukkan citra negatif; 2) citra tersebut dipengaruhi oleh: a) sikap pekerja media dalam mengonstruksi fakta; b) penggunaan situasi konflik pengesahan sebagai dasar pemberitaan; c) orientasi institusi pada kepentingan ekonomi; d) kondisi sosiokultural, hampir setengah penduduk Indonesia bekerja sebagai buruh/karyawan dengan kondisi sosial ekonomi yang belum merata, ketimpangan sosial ekonomi yang cukup tinggi, dan kekhawatiran publik atas pendegradasian hak-hak dan kesejahteraan buruh/pekerja; 3) representasi dan proses penyajian berita relevan sebagai materi ajar menulis artikel berita di SMA karena sesuai dengan Kompetensi Inti dan Kompetensi Dasar serta sesuai dengan kebutuhan siswa terhadap materi ajar yang baik, memuat pemahaman konteks dan memuat pemodelan teks.

 
POSTER DIALOG EDUKASI COVID-19 DALAM INSTAGRAM KEMENTERIAN KESEHATAN: ANALISIS TEKSTUAL
Authors: Asih Lutfi Anggoro , Rakhmawati Ani , Ulya Chafit
Published: January 2023

Penelitian ini dilatarbelakangi oleh kurangnya pemahamaan masyarakat dalam memahami sebuah wacana, khususnya tentang pencegahan dan penanganan Covid-19. Penelitian ini bertujuan untuk mengetahui dan menjelaskan bentuk analisis wacana tekstual dalam dialog poster edukasi Covid-19 yang diunggah dalam akun Instagram Kementerian Kesehatan Republik Indonesia. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif. Sumber data penelitian ini berupa tiga poster dialog edukasi Covid-19 dalam unggahan akun Instagram Kementerian Kesehatan Republik Indonesia (@kemenkes_ri). Teknik pengumpulan data yang digunakan adalah purposive sampling. Teknik pengumpulan data menggunakan analisis dokumen. Validitas data menggunakan triangulasi teori. Analisis data menggunakan analisis mengalir. Hasil penelitian ini menunjukkan bahwa analisis wacana tekstual pada aspek gramatikal didominasi bentuk pengacuan sebanyak 51% dan pada aspek leksikal didominasi bentuk repetisi sebanyak 67%. Pengacuan karena mendominasi setiap tuturan atau kalimat tidak lepas dari keinginan yang mengikuti atau mengikutinya. Repetisi karena digunakan untuk mempertegas maksud yang ingin disampaikan oleh khususnya untuk mengedukasi masyarakat terkait pandemi Covid-19.
EFFECT OF TWO-STAGE FUEL COMBUSTION IN DIESEL CYLINDER ON ITS INDICATOR INDICATORS
Authors: Prokhorenko A. , Kravchenko S. , Solodky E. , Shelestov M.
Published: January 2023

The use of two-stage fuel injection into the diesel cylinder is an effective means of reducing the noise of its operation and reducing emissions of nitrogen oxides with exhaust gases. In this work, a computational-experimental study is based on a method in which part of the experimental indicator is replaced by the results of its numerical synthesis, performed using mathematical modeling of processes in the engine cylinder. The research was carried out on an experimental single-cylinder engine Ch8.8/8.2, equipped with a high-pressure fuel supply system. The mathematical model of working processes in the cylinder of the experimental engine is developed and identified. When studying the effect of two-stage combustion on the indicator process of the engine, the parameters that determine the law of fuel combustion, i.e. the angles of the beginning of the injection of the main and pilot portions of fuel changed.

It is shown that the value of the indicator efficiency of the cycle is almost independent of the introduction and advancement at the angle of rotation of the crankshaft of the moment of pre-combustion at a constant ignition moment of the main portion of the fuel. However, reducing the starting angle of the pilot fuel injection leads to an increase in the maximum pressure of the cycle pz and the maximum rate of pressure rise, as a consequence of increasing engine noise.

It is proved that it is possible to start the ignition of the main portion of the fuel without a significant decrease in the average indicator pressure and with a decrease in the values of pz and dr/dφmax when creating pre-combustion of fuel by 20 degrees turning the crankshaft to the main. The rational angle of advance of the injection of the pilot portion of fuel is 10 ... 12 deg. turning the crankshaft to inject the main portion. The obtained results show that the proposed measures - the introduction of pre-combustion 10… 25% of the cycle feed - can reduce the noise level of the engine while maintaining the level of the average indicator pressure and reduce the maximum cycle pressure.
RESEARCH OF A HIGH-EFFICIENCY CHARGE AIR COOLER
Authors: Savchenko A.V. , Shelestov M.S.
Published: January 2023

Currently, internal combustion engines have become widespread as sources of mechanical energy in many areas of human activity. It is the internal combustion engines that were and remain the most widespread in transport, where, as a rule, strict requirements are put forward for the mass-dimensional characteristics of the engines and the power plant as a whole. In order to meet these requirements, there is a constant increase in the level of forcing of the engines. For diesel engines, the most common technical measure that provides an increase in the level of engine forcing with almost unchanged weight and dimensional characteristics is an increase in supercharging pressure. However, as a result of air compression, its temperature increases, which is proportional to the degree of increase in air pressure in the compressor. An increase in air temperature causes a decrease in the mass charge of the cylinders, and therefore, a significant deterioration in the fuel combustion process. It also causes an increase in the level of maximum temperatures of the cycle, which in turn causes an increase in thermal loads and the rate of formation of nitrogen oxides in diesel cylinders. The above determines the urgency of the tasks of implementing effective charge air coolers in modern high-pressure transport diesel engines. This technical problem can be solved using air or liquid coolers. The article considers a liquid cooler, because compared to an air cooler, it can be made more compact, allows to achieve a much smaller length and volume of the intake tract, as well as to simplify the layout of the intake tract as part of the power plant as a whole, which is a priority for diesel engines. The article considers the influence of the design parameters of the supercharged air cooler on its overall characteristics and the hydraulic resistance of the supercharged air flowing through the cooler. Thus, the article provides data indicating the possibility of making a compact, highly efficient supercharged air cooler while maintaining its hydraulic resistance at an acceptable level by choosing rational parameters.
CHARACTERISTICS OF FUEL DISTRIBUTION IN THE VOLUME OF THE COMBUSTION CHAMBER OF TWO-STROKE DIESEL ENGINE WITH OPPOSITE MOVEMENT OF PISTONS
Authors: Lal A.G. , Shelestov M.S.
Published: January 2023

The paper analyzes ways of organizing mixture formation in a two-stroke diesel engine with reciprocating piston move-ment. Issues such as heat exchange with the walls, atomization and evaporation of fuel, distribution of the fuel jet and fuel vapors in the volume of the combustion chamber are considered. It is noted that the tangential vortex, which is achieved thanks to the special profiling of the windows, has a significant impact on the processes in the two-stroke diesel cylinder. The movement of the air charge is an important and critical factor in the formation of a mixture, the intensity of the vortex is estimated by the vortex number, which is the ratio of the number of revolutions of the vortex to the engine speed. In the process of volumetric mixture formation, the basic issues are fuel atomization and uniform distribution in the air volume. Fuel spraying has such criteria as the degree of dispersion and uniformity of the ignited fuel. The degree of dispersion is estimated by the average diameter of drops in the sprayed fuel. And the uniformity of spraying in the volume of the combustion chamber depends on the fuel jet shape, range of the jet, swirling air, the type of combustion chamber. The presence of long-range jets must necessarily be accompanied by the necessary intensity of air charge movement along the wall. Otherwise, in the conditions of the hot wall, which is typical for the domestic 6ChN12/2×12, in the places of contact of the jets with the overheated wall, significant solid deposits of soot are found, and these deposits have the character of coke, obtained as a result of fuel cracking. The mentioned drawback cannot be eliminated only by changing the wall temperature, if its main cause is not eliminated simultaneously, namely, a local lack of air (for example, in the central part of the piston bottom). Development of measures for prevention of this phenomenon will improve the engine's environmental friendliness and efficiency.
IMPROVING THE ACCURACY OF SYSTEMS FOR GRAVIMETRIC CONTROL OF PARTICULATE MATTER IN EXHAUST GASES OF TRANSPORT DIESEL ENGINES
Authors: Polyvianchuk A.P. , Khreshchenetskyi V.L. , Antonuk O.P. , Mitko M.V. , Dmitrieva A.V.
Published: January 2023

The requirements of regulatory documents - UNECE Regulations R-49, R-96, international standard ISO 8178, etc. were analyzed regarding the technical characteristics and conditions of use of reference full-flow and alternative partial-flow systems (tunnels) for diluting the exhaust gases of transport diesel engines with air and carrying out gravimetric control of the content of solid particles in them. The world and domestic experience of operating dilution tunnels of various types - full-flow with 1st and 2nd dilution lines and partial-flow mini- and micro-tunnels and partial-flow mini- and micro-tunnels were studied, which made it possible to establish empirical dependencies for evaluating the degree of influence of the temperature regimes of gas sampling on the accuracy of measurements of mass emissions particulate matter in different modes of diesel operation. Mathematical models have been developed to determine the sample temperatures of diluted exhaust gases in tunnels of various types and to estimate the resulting measurement error of the normalized average operational emission of diesel particulate matter - the PM indicator. Based on the results of environmental tests of transport diesel engines 1Ch12/14 and 4ChN12/14 according to the 13-step ESC test cycle and developed mathematical models, calculation studies were carried out to assess the effect on the accuracy of a mini-tunnel with a diameter of 10 cm and a micro-tunnel with a diameter of 3 cm of the sampling temperature regimes, which were compared with a reference tunnel with a diameter of 46 cm. The research results proved the expediency of adjusting the temperature of the sample in the micro-tunnel to increase its accuracy by eliminating the significant methodical errors of measuring the PM indicator, which amount to -1.6 ... -1.7%. It was established that in the mini-tunnel the corresponding errors are not significant and amount to -0.3 ... -0.4%, which indicates that there is no need to adjust the temperature of the sample in this system.
FUZZY ESTIMATION PROCEDURE OF THE CONCENTRATION OF THE COMPONENTS OF A SULFURIC ACID PICKLING SOLUTION
Authors: Ilyunin O. , Кhodak M. , Yurchenko O. , Sapeha O.
Published: January 2023

The article is devoted to the issue of determining the level of concentration of individual components of working solutions. The relevance of the topic lies in the fact that some impurities in solutions (for example, when pickling steel) cannot be measured automatically, which reduces the efficiency of the process and increases the load on the solution regeneration section. Also, impurities are hazardous waste for the environment and humans.

The development of a method for the operational control of the composition of the pickling solution components in pickling baths is the main task of the work. A detailed substantiation of the choice of the mathematical apparatus of the method is given. The process of fuzzy identification of the composition of the components is carried out by the number of pixels with certain digital color RGB codes from digital images of the control doses of the solution. A set of technical means for providing the method for practical implementation in the technological process is described. A prototype of a graphical user interface (GUI) for the proposed method for identifying the composition of technological liquid solutions, developed in the Processing 3.0 integrated environment using applications from the Open Source Computer Vision Library, is presented.

A technique for extracting experimental data for filling the base of a fuzzy classifier with model reference points is proposed. Its essence lies in simultaneous measurements of the concentration of the components of the pickling solution by classical methods of titration and dry residues and the proposed method with a step equal to the regulated accuracy. The results of approbation of the proposed method are presented.

The presented technique for obtaining a fuzzy classifier can be used to develop IT tools for the operational control of the composition of various liquid solutions with opaque colored components and color identification of defects in various flat surfaces, provided that they are color distinguishable and determine the boundaries of RGB - intervals for assessing the color of individual component (defects).
The Responsiveness of Fiqh and Its Local Wisdom of Pengajian Pitulasan Menara Kudus
Authors: Munawaroh Lathifah , Abdillah Junaidi
Published: January 2023

The characteristics of fiqh with its local wisdom in the Pengajian Pitulasan are based on the charismatic authority approach of Sunan and Kiai figures who gave a philosophical view named Gusjigang. Gusjigang is a dialectic reflection between fiqh and local wisdom in Kudus city. This philosophy is applied in daily life which leads to being a completely human character. The form of responsiveness fiqh found in the Pengajian Pitulasan Yayasan Menara Kudus is to use the method and approach of qauli by involving dialogical elements that reflect the public mind even though it is still at a small level. This research is a type of field research based on literature review as know as library research with the documentary-historical method. The data also shows that the form of fiqh responsiveness in the Pengajian Pitulasan has absorbed various dimensions of life such as the economic, social, health, and other fields. Among the forms of fiqh that represent the dialectic between fiqh and its local wisdom in the Pengajian Pitulasan are: the role of the Kiai is clearly seem in preserving the local culture of Pengajian Pitulasan Yayasan Menara Kudus and avoiding sacrifices with the cow for the Kudus Kulon community.
Kyai NU’s Patrons as an Agent of Social Change and Environmental Marine Conservation: A Case Study in Paciran Lamongan
Authors: Rozuli Ahmad Imron , Yasin Muhamad , Kholish Moh. Anas , Dalle Abd. Rahman Ambo’
Published: January 2023

This article aims to examine the patrons of NU’s Kyai as an agent of social change, as well as environmental conservation in the coastal communities of Lamongan through a green fatwa on the prohibition of destructive fishing. The research method used in this study is qualitative descriptive research with techniques for collecting indepth interview data, participant observation, and FGD, as well as documentation. The results of this article research study show that NU’s Kyai plays a significant role in carrying out social changes in the Lamongan coastal community. The role of social change in NU and environmental conservation is expressed through green fatwas on the preservation of marine ecosystems by banning destructive fishing gear. NU’s Kyai who are considered authoritative patrons of the Lamongan coastal community base their social construction on priority jurisprudence considerations, namely by prioritizing general and long-term benefits, rather than special benefits and benefits that are short-term. According to the NU’s Kyai, preserving marine ecosystems by prohibiting destructive fishing gear is a general and long-term benefit that must be prioritized, rather than the welfare of a handful of fishing vessels with destructive tools.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 07.01.2023 г. по 13.01.2023 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: January 2023

В обзоре представлена информация по циркулирующим в настоящее время вари-антам вируса SARS-COV-2 вызывающих озабоченность (VOC), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 7 по 13 января 2023 г.
Failure Mechanisms and Constitutive Model of Composite Rock under Dynamic Loading
Authors: Li Jinyu , Zhao Hongbao , Ji Dongliang , Wan Huhu , Li Chen
Published: January 2023

In order to investigate the dynamic response characteristics of composite rock with different joint angles, static compression test and dynamic impact test are carried out using WDW-300E servo pressure-testing machine and split Hopkinson pressure bar (SHPB) test system. The dynamic compressive strength, energy dissipation, and failure modes are compared between rock coal (R-C) and coal rock (C-R). Furthermore, a 3D SHPB simulation system is constructed using coupling finite difference method and discrete element method (FDM-DEM) to reproduce the energy evolution and failure modes of composite rock with different joint angles, and the fabric tensor is obtained based on secondary development. Finally, a constitutive model of composite rock is established considering joint angles. The results of experiment, simulation, and theoretical analysis show that for the case of uniaxial compression test, with the increase of joint angle, the peak stress of composite rock shows obvious U-shaped change, and the elastic modulus increases gradually while the peak strain decreases gradually. For the case of dynamic impact test, the peak stress, strain, and energy dissipation values of composite rock decrease first and then increase with the increase of angle, and the elastic modulus of composite rock increases monotonically after a slight fluctuation of 30°. The stress, energy dissipation and elastic modulus of composite rock R-C are larger than that of composite rock C-R. However, the strain value of composite rock R-C is generally less than of composite rock C-R. The failure mode of composite rock with small and large angle is mainly splitting under dynamic impact, and the fracture fragmentation is relatively small with high energy absorption rate, while the fracture fragmentation is mainly shear and splitting mixed failure with low energy absorption rate. The energy accumulation and transformation process inside the composite rock are analyzed by 3D simulation system, and the damage of the composite rock under impact is mainly concentrated on the coal side, and peak values of contact number and contact force with different joint angles are calculated by using fabric tensor. Based on Weibull distribution, a constitutive model of composite rock is constructed considering initial damage and dynamic failure effect, which is in good agreement with experimental and simulation results, verifying the correctness of the constructed model.
Computational Fluid Dynamics Modeling of Pseudotransient Perforation Erosion in a Limited-Entry Completion Cluster
Authors: Kebert Brent A. , Miskimins Jennifer L. , Soehner Gage , Hunter William
Published: January 2023

Hydraulic fracturing in limited-entry (LE) completion designs relies on maintaining a high bottomhole treating pressure (BHTP). LE requires high perforation friction to maintain an even distribution of the hydraulic fracturing slurry. As sand exits the perforations, the perforations start to erode. The erosional change in the perforation alters the desired perforation friction and subsequent BHTP. As operators rely on multistage hydraulic fracturing to generate economic production, the issue of perforation erosion becomes inherently repetitive from stage to stage and cumulatively a significant issue. The industry has seen how a perforation can change from a before-and-after perspective with downhole cameras and imaging techniques before and after treatments. However, a more detailed understanding of the dynamic process of perforation erosion can give a better expectation of perforation performance throughout a hydraulic fracturing treatment and not just pretreatment compared to post-treatment.

Computational fluid dynamics (CFD) is a quickly emerging tool in the industry. CFD aims to model fluid flow by numerically solving the Naiver-Stokes equations within a specified domain. Along with modeling fluid systems, CFD has the capability to model dispersed particles within the fluid. Once the particles are introduced into the fluid, the domain can also be eroded away within the CFD model. By utilizing the erosional capabilities of CFD, paired with the flow of a hydraulic fracturing slurry, perforation erosion can be investigated transiently throughout an entire hydraulic fracturing stage.

This work presents a better dynamic understanding of perforation erosion rather than just a “before vs. after” comparison. The CFD modeling methodology used to achieve the correct erosional pattern observed in the field is presented. Throughout this work, four different hydraulic fracturing completion parameters are investigated to determine the respective roles in perforation erosion. The four parameters include proppant size, proppant concentration, fracturing fluid viscosity, and proppant concentration ramping schedules. By investigating the impact that controlled design parameters have on perforation erosion, perforation erosion can be better anticipated to deliver improved completion results.
Determining Significant Factors Responsible for the Successful Managing of the Covid-19 Pandemic in Taiwan
Authors: Halide Halmar , Andika Andika , Wulandari Putri
Published: January 2023

The covid-19 pandemic badly affects most countries in the world both sociologically and economically. Taiwan, however, manages to handle its pandemic remarkably well before and after its Covid-19 cases spike. This paper aims to describe Taiwan's strategy for keeping the cases low and to identify significant factors related to this spike. These factors are found through the use of a stepwise regression model. The model inputs are 15 daily data sets that belong to the three grouped indicators: Containment and closures, Economic responses, and Health systems. In addition, the number of Covid-19 tests and changes in the number of people attending indoor and outdoor activities are also given as model inputs. The model output is the daily covid-19 confirmed cases. It is found that restrictions on the internal move, government campaign, debt or contract relief, indoor activities changes, work closures, and their interactions are amongst the most significant factors leading to the sharp jump in Covid-19 cases. The model is able to explain almost 88% of the cases. It is important that these factors are taken into consideration by any government in its preparation for an upcoming pandemic.
Addressing the gap for racially diverse research involvement: the King’s Model for Minority Ethnic Research Participant Recruitment
Authors: Chaudhuri K Ray , Podlewska Aleksandra , Lau Yue Hui , Gonde Chris , McIntosh Alysha , Qamar Mubasher A , O’Donoghue Simon , Larcombe Karen , Adeeko Maria , Gupta Atul , Bajwah Sabrina , Lafond Sarah , Awogbemila Olabisi , Coller Riaan van , Murtagh Ann-Marie , Ocloo Josephine Enyoam
Published: January 2023

Background
Ethnic minorities (EM) are still underrepresented in research recruitment. Despite wide literature outlining the barriers, enablers and recommendations for driving inclusion and diversity in research, there is still little evidence for successful diversity in research participation, which has a direct impact on the quality of care provided to ethnically diverse individuals.
Methods
In the light of the Covid-19 pandemic and the key public health need to address the disparity in care provided to non-white populations, we applied the recommendations made by Ocloo and Matthews (2016) on diverse engagement in PPI groups to promote inclusive research recruitment.
Results
Our results demonstrate a significantly higher recruitment of EM populations to studies, when compared to recruitment in years 2017–2020.
Conclusions
Enriched by additional recommendations based on our experiences during the Covid-19 research recruitment drive, we propose the King’s Model is used to support ethnically diverse research recruitment. Further evidence is needed to replicate our findings, although this preliminary evidence provides granular details necessary to address the key unmet need of validating clinical research outcomes in non-white populations.
Occurrence of Tick-Borne Pathogens in Ticks Collected from Cattle at Iringa and Kilombero District Councils, Tanzania
Authors: Magesa Walter , Haji Isihaka , Nzalawahe Jahashi S. , Kazwala Rudovick
Published: January 2023

Background
Ticks and tick-borne diseases undermine livestock production and productivity in Tanzania. Cattle in Tanzania are challenged by several tick species and tick-borne disease which are known to be endemic in cattle such as Anaplasmosis, Theileriosis and Babesiosis. However, there is insufficient information on tick and associated tick-borne pathogens in Tanzania. Therefore, this study was conducted to determine the occurrence of tick-borne pathogens including Anaplasma, Theileria and Babesia spp., in ticks from Kilombero and Iringa district councils of Tanzania.
Method
During January to August 2021, a repeated cross-section study was carried out and a total of 1,889 ticks were collected from 304 randomly selected cattle. The ticks were morphologically identified using morphological keys and a stereomicroscope. The identified tick species were grouped into 91 pools of 1–30 ticks according to species, sex, and collection site for analysis. The tick-borne pathogens were then detected from the tick pools using Polymerase Chain Reaction (PCR) targeting Anaplasma and Theileria or Babesia spp. Chi square/Fisher’s Exact test was performed to detect the difference between the proportion of pathogen positive tick pools in Iringa and Kilombero district councils and seasons.
Results
Overall, Anaplasma and Theileria/Babesia spp. were detected by PCR in (70.33%, n = 64) tick pools. The detection rate of both Anaplasma and Theileria/Babesia spp. was high in Amblyomma lepidum (25.00%, n = 16) followed by Rhipicephalus evertsi (23.44%, n = 15) tick pools. Tick pools from Iringa district had a significantly higher proportion of pathogen detection rate (91.04%, n = 61) as compared to Kilombero (12.50%, n = 3), (95% CI, p < 0.001). The co-infection rate of Anaplasma spp. and Theileria/Babesia spp. in all tick pools was (32.97%, n = 30). A significant higher co-infection rate of (43.28%, n = 29) was recorded in tick pools from Iringa district council (95% CI, p < 0.05).
Conclusion
The results showed a high tick-borne pathogen detection rate on tick pools collected from cattle from the study areas which might increase the risk of tick-borne diseases transmission and reduce animal production and productivity. Therefore, the ticks and tick-borne pathogens in the study areas highlight the need for strategic tick control approaches.
Mental health status of patients with a rare disease in consultation-liaison psychiatry service: Analysis of 22 patients with erythroderma
Authors: Duan Yanping , Wei Jing , Zhang Meng , Jiang Yinan , Geng Wenqi , Cao Jinya , Li Tao , Zhao Xiaohui , Qu Weixuan , Sun Ruixue , Hong Xia , Jin hongzhong
Published: January 2023

Background The mental health of patients with rare diseases deserves attention, but conducting the research is difficult. This study uses medical records of consultation-liaison psychiatry and provides the possibility of examining the mental health of patients with rare diseases.
Methods The medical records of patients diagnosed with erythroderma in the consultation-liaison psychiatry system of the Department of Psychological Medicine of Peking Union Medical College Hospital were analyzed.
Results Twenty two patients with erythroderma received psychiatric consultations during 2008 to 2021, and 8 patients (36.4%) were Beijing natives. The course of the disease ranged from 22 days to 33 years. Seven patients (31.8%) were diagnosed with erythroderma psoriasis. The common reasons for psychiatric consultation were anxious or depressive symptoms (10/22, 45.5%), insomnia (8/22, 36.4%), and disease pressure (4/22, 18.2%). The most common diagnosis were “depression”, “depressive state” or “anxious depression”, followed by “anxious state” or “anxiety”, “insomnia” and “delirium”. Antidepressants, benzodiazepines or nonbenzodiazepine sleep aids, and antipsychotics were prescribed. Five patients (22.7%) received only psychological counseling.
Conclusions Anxiety, depression and insomnia were common in patients with erythroderma. Patients with severe disease or elderly inpatients might present with delirium, which is a common reason for consultation-liaison psychiatry. Antidepressants, antipsychotics and sleeping aids arecommonly used in drug therapy. Resource-oriented psychological counseling was the most common intervention.
The dynamic changes of recurrent Immune reconstitution inflammatory syndrome of an AIDS patient with cytomegalovirus encephalitis and pulmonary tuberculosis：a case report
Authors: Song Shulin , Jiang Changyue , Gan Donghui , Lu Yibo
Published: January 2023

Background
This study describes an AIDS patient with central nervous systems tuberculosis, and cytomegalovirus infection who experienced immune reconstitution inflammatory syndromes associated to cytomegalovirus encephalitis and pulmonary tuberculosis while receiving antiretroviral therapy.
Case presentation
A 59-year-old male with fever of unknown origin with dizziness, fatigue, loss of appetite, fear of cold, occasional babbling during fever, and paroxysmal cough as the main symptoms three days was referred to our hospital Cerebrospinal fluid examination showed a cytomegaloviral load of 3.4×103 copies/ml and a positive mycobacterium tuberculosis recombination test. Cerebrospinal fluid gene X-pert MTB/RIF test showed mycobacterium tuberculosis infection without rifampicin resistance. Anti-tuberculosis treatment and anti-cytomegalovirus therapy were administered, and clinical and laboratory abnormalities were improved. The patient's CD4+ T lymphocyte count was 70 cells/μl, and antiretroviral therapy was started 24 days after the start of anti-tuberculosis treatment.
Clinical symptoms reappeared on day 33 after antiretroviral therapy treatment. Relapsing - immune reconstitution inflammatory syndrome was considered as the most likely diagnosis. After the addition of a small amount of dexamethasone to continue anti-tuberculosis and anti-cytomegalovirus therapy, the patient's symptoms disappeared and imaging was reduced in scope. There was no recurrence of clinical symptoms at 2 years of outpatient follow-up.
Conclusion
It is important to take aware of the emergence of multiple infections and the associated immune reconstitution inflammatory syndrome in AIDS. Once the immune reconstitution inflammatory syndrome manifests, a proper diagnosis and continual of treatment are imperative to the patient's recovery.
Simulation study and HSPICE modeling of single-event transients induced by secondary ions not incident to the drain in nanoscale CMOS technology
Authors: Wu Hao , Jin Gang , Yi Tengyue , Zhuang Yiqi
Published: January 2023

Terrestrial single-event transients (SETs) are mainly induced by secondary ions of neutron-induced nuclear reactions, which do not cross the sensitive drain in most cases. Technology computer-aided design (TCAD) simulations show that in those cases, both diffusion-collection current and burst-plateau-type current waveform could occur in nanoscale complementary metal-oxide-semiconductor (CMOS) technology. The necessity of including recombination effect in diffusion-collection model is identified, and an equivalent circuit model (ECM) is established to describe SETs induced by secondary ions with short distance to the drain. Both models are verified by TCAD simulations.
Jianpi Qinghua Sanyu Decoction attenuates insulin-like growth factor 1-induced GES-1 cell proliferation by suppressing the AKT pathway based on network pharmacology analysis
Authors: Liu Qihong , Zhao Peiling , Lin Xiaoying , Zhang Xinran , Wang Wenrong , Hu Jianyun , Chen Ying , Lin Lumin , Shen Aling , Ke Xiao
Published: January 2023

Raised erosive gastritis (REG) is a gastric mucosal lesion with characteristic radiological and endoscopic features. Jianpi Qinghua Sanyu Decoction (JPQHSYD) may be effective against REG, but its therapeutic effects and underlying molecular mechanisms have yet to be investigated. A network pharmacology analysis was performed to identify itsJPQHSYD active ingredients, potential targets, and pathways in REG treatment. Following database mining, our current study identified 245 compounds and 320 potential targets, as well as 94 common targets with REG. The construction of a traditional Chinese medicine (TCM) comprehensive network (Drug-Ingredients-Gene symbols-Disease network) identified ten potentially active compounds (including Quercetin) and 35 potential targets (including AKT1), as well as enriched signaling pathways (including cell proliferation and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt)). In vitro studies revealed that JPQHSYD significantly inhibits cell growth and viability while also down-regulating p-AKT, Bcl-2, CDK4, and CyclinD1 expression and up-regulating Bax protein levels in insulin-like growth factor 1 (IGF-1)-stimulated GES-1 cells. This study provides novel insights into the mechanism of action of JPQHSYD in REG treatment, implying that suppressing the AKT pathway may be one of the essential underlying anti-REG mechanisms of JPQHSYD.
Association Between Genetically Predicted Expression of TPMT and Azathioprine Adverse Events
Authors: Davis Alyssa , Dickson Alyson L. , Daniel Laura L. , Nepal Puran , Zanussi Jacy , Miller-Fleming Tyne W. , Straub Peter S. , Wei Wei-Qi , Liu Ge , Cox Nancy J. , Hung Adriana M. , Feng QiPing , Stein C. Michael , Chung Cecilia P.
Published: January 2023

Polymorphisms thiopurine-S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) can increase the risk of azathioprine myelotoxicity, but little is known about other genetic factors that increase risk for azathioprine-associated side effects. PrediXcan is a gene-based association method that estimates the expression of individuals’ genes and examines their correlation to specified phenotypes. As proof of concept for using PrediXcan as a tool to define the association between genetic factors and azathioprine side effects, we aimed to determine whether the genetically predicted expression of TPMT or NUDT15 was associated with leukopenia or other known side effects. In a retrospective cohort of 1364 new users of azathioprine with EHR-reported White race, we used PrediXcan to impute expression in liver tissue, tested its association with pre-specified phecodes representing known side effects (e.g., skin cancer), and completed chart review to confirm cases. Among confirmed cases, patients in the lowest tertile (i.e., lowest predicted) of TPMT expression had significantly higher odds of developing leukopenia (OR=3.30, 95%CI: 1.07-10.20, p=0.04) versus those in the highest tertile; no other side effects were significant. The results suggest that this methodology could be deployed on a larger scale to uncover associations between genetic factors and drug side effects for more personalized care.
Low-Level Vertical Structure of Cross-Equatorial Flows in Boreal Summer
Authors: Zhang Xinming , SUBRAHMANYAM M. V.
Published: January 2023

Cross-equatorial flows (CEFs) are critical channels for mass, momentum, and water vapor exchange between the southern and northern hemispheres and have considerable influence on the global air-sea system. This study uses ERA-5 reanalysis data to find the relationship between vertical structure characteristics of global low-level CEFs in boreal summer and their correlation with sea surface temperature (SST). The research demonstrates that the vertical structure of CEFs is independent. The windspeed core is mainly at 925hPa or 1000hPa, and the vertical structure of CEFs has an obvious correlation. Through EOF analysis, two main vertical structures of the eastern hemisphere's CEFs are obtained: "consistent variation " and "opposite variation. " The vertical structures of the western hemisphere only have "opposite variation "and have greater longitude spans with tinner southerly wind thickness. The correlation analysis between CEFs and SST indicates Pacific Decadal Oscillation, two types of ENSO, and SST variations in the Indian and central Pacific oceans. SST variations can relate to the vertical structure change of CEFs.
A nomogram based on imaging features and serological indicators for predicting efficacy of neoadjuvant chemotherapy in gastric cancer
Authors: Zhou Jie , Wang Haitao , Ding Wei , Feng Yuehua , Xin Zhaoyu , Liu Zhilin
Published: January 2023

Background Neoadjuvant chemotherapy (NAC) has been proven to be a powerful therapeutic choice for the advanced gastric cancer. However, the overall response rate is only 20-40% and there is a lack of sensitive indicators to predict the efficacy of the therapy. In this study, we aimed to construct a nomogram to predict the efficacy of NAC for gastric cancer.
Method The study comprised 60 gastric cancer patients who underwent NAC. Patients were classified into effective (TRG 0-2) and ineffective (TRG 3) groups based on the Tumor Regression Grade (TRG). Clinical data were compared between the two groups, and binary logistic regression analysis was used to screen the independent factors that could predict efficacy. Then, a new nomogram was created and validated.
Result In this study, a total of 33 patients (33/60, 55%) were successfully treated with NAC. Platelet Distribution Width, Adenosine Deaminase, Urea, and clinical T-stage of tumor were independent factors for predicting the efficacy of NAC for gastric cancer treatment (P < 0.05). The consistency index of the constructed Nomogram was 0.923 (95% CI: 0.851-0.995).
Conclusion The nomogram developed in this study has a high degree of clinical utility, calibration and discrimination, which can help clinicians accurately predict the efficacy of NAC for gastric cancer patients.
IGF2BP2-meidated m 6 A modification of CSF2 reprograms MSC to promote gastric cancer progression
Authors: Ji Runbi , Wu Chenxi , Lin Jiang , Gu Hongbing , Fu Min , Zhang Xiaoxin , Li Yongkang , Xu Jiajin , Zhang Xu
Published: January 2023

Background
The interaction between tumor cells and stromal cells in tumor microenvironment is critical for cancer progression. MSCs represent a dominant source of tumor stromal cells and exert pro-oncogenic activities when reprogrammed by tumor. The precise mechanism for MSC reprogramming in gastric cancer has not been fully understood.
Methods
The gene and protein expression levels were examined by qRT-PCR, western blot, and immunohistochemistry. The biological functions of gastric cancer cells were detected by in vitro and in vivo experiments. RNA‐sequencing, RNA immunoprecipitation (RIP), and meRIP assays were conducted to explore the potential regulatory mechanisms.
Results
We identified that the expression and N6-methyladenosine (m6A) modification levels of colony stimulating factor 2 (CSF2) were significantly increased in gastric cancer MSCs. CSF2 upregulation and stimulation induced the reprogramming of normal MSCs to cancer-promoting MSCs, which promoted the proliferation, migration, and drug resistance of gastric cancer cells through the secretion of various pro-inflammatory factors. We further demonstrated that CSF2 mRNA was recognized and stabilized by m6A reader IGF2BP2, whose overexpression mimicked the effect of CSF2 on MSCs to promote gastric cancer progression. Finally, we found that CSF2 exerted the reprograming effect of MSCs by inducing the ubiquitination of Notch1.
Conclusions
The increased m6A modification of CSF2 by IGF2BP2 reprogrammed MSCs into a cancer-promoting phenotype. The IGF2BP2/CSF2/Notch1 axis represents a new mechanism for MSC programming in gastric cancer and offers a novel target for gastric cancer therapy.