bluuebunny/crossref_metadata_2025 huggingface dataset:
Production de biogaz à partir des déjections bovines en milieu aride: cas du M’Zab (Algérie)
Authors: Douag-Tirichine Nassima , Benkhelifa Abdelhak , Bousdira Khalida
Published: December 2023

L’objectif de ce travail expérimental est de valoriser les déchets issus de l’élevage bovin, en utilisant les bouses de vaches comme substrat pour la production de biogaz qui peut être directement exploitable pour un usage domestique dans une région enclavée et aride de l’Algérie le M’Zab. Pour cela, nous avons utilisé un système constitué d’une enceinte fermée de 800 litres: c’est le digesteur, une cloche gazométrique de 600 litres pour le stockage du biogaz produit, et un chauffe-eau électrique de 75 litres pour le chauffage du digesteur. Les paramètres de la digestion anaérobie ont été suivis régulièrement. Le contrôle de la température est assuré par un thermostat mécanique et l’ajustement du pH est effectué par l’addition de l’eau de chaux afin de maintenir les valeurs du pH proches de la neutralité 7. Pour ce qui est de l’isolation thermique, le digesteur est recouvert avec de la laine de verre afin de maintenir une température stable et diminuer les écarts de température entre le jour et la nuit. L’épuration est faite par passage du biogaz à travers de la chaux, et le dosage du méthane est effectué par une méthode volumétrique. L’apparition du méthane dans le biogaz a été observée au bout du 5ème jour de fermentation avec une quantité de 40-45 %. Et le maximum a été atteint au 33ème jour de la méthanisation avec 89 % de CH4 dans le biogaz.
Modélisation spatio-temporelle de la dispersion du dioxyde de soufre près d’un site industriel: Réseau de neurone & bio-indicateur
Authors: Taieb Dalila , Hamdi Essia
Published: December 2023

Cet article propose un état de l’art sur la modélisation basée sur l’utilisation des méthodes numériques et géostatiques pour la prévision spatio-temporelle de la pollution atmosphérique en SO2 dans la région du Gabès (Sud-Est Tunisien). Les outils numériques en mettant l’accent sur un modèle non linéaire, les réseaux de neurones sont applicables aux données horaires (2012) en SO2 fournies par l’Agence Nationale de Protection de l’Environnement (ANPE) pour faire la paramétrisation de SO2 en fonction des facteurs externes, ainsi que la prévision des concentrations horaires d’un jour de plus. Le modèle déterministe et probabiliste est applicable à des concentrations de soufre mesurés dans le matériel végétal; le Malva ageptiaca, un bio-indicateur passif présente l’intérêt d’interpoler et de cartographier le soufre dans la zone d’étude et permet de servir, dans les conditions de perturbation, de signal d’alarme sur la zone la plus polluée.
Commande d’une éolienne à base d’une génératrice synchrone à aimant permanent avec convertisseur complet
Authors: El Hani Soumia , Guedira Said
Published: December 2023

Dans le présent article, nous discutons le problème de la recherche de la puissance maximum d’une éolienne, (Maximum Power Point Tracking, ‘MPPT’), à base d’une Génératrice Synchrone à Aimant Permanant (PMSG) débitant dans le réseau de puissance à travers une chaîne complète de convertisseurs statiques. Pour cela, nous proposons un schéma de commande de la machine synchrone, comportant un premier dispositif alternatif/continu suivi d’un second dispositif continu/alternatif. Le principe MPPT repose sur la variation de vitesse de la turbine suivant celle du vent en cas de raccordement indirect de la génératrice avec le réseau. Les simulations sur Matlab-Simulink, présentées en fin d’article, confirment une bonne adéquation du schéma de commande, du choix des paramètres de réglage ainsi que l’architecture de la chaîne de conversion aux objectifs assignés.
Simulation en régime dynamique d’un système de réfrigération solaire à adsorption
Authors: Rabhi Kamel , Chaouki Ali , Ben Bacha Habib
Published: December 2023

Dans ce travail proposé, on s’intéresse à la conception, la modélisation dynamique et la simulation numérique du fonctionnement d’un système de réfrigération à adsorption par l’énergie solaire utilisant un couple le gel de silice et l’eau. Cette technique fonctionne avec l’énergie solaire et utilise des fluides frigorigènes naturels qui non aucun effet sur l’environnement. Le système est étudié numériquement et résolu en utilisant la méthode de volume finie. Nous avons étudié l’effet de grosseur de grain de gel de silice et la température de régénération sur la teneur en eau pendent la phase de désorption.
Etude expérimentale d’un capteur solaire plan muni d’un collecteur sous forme de serpentin
Authors: Ketfi Omar , Merzouk Mustapha , Kasbadji Merzouk Nachida , Elmetenani Said , Lafri Djamel
Published: December 2023

Le but de ce travail est la réalisation et l’expérimentation d’un capteur solaire plan à eau réalisé au niveau de l’Institut de Mécanique à l’Université de Blida conformément aux conditions exigées par la norme Européenne EN 12975-2. Les tests expérimentaux menés sur le capteur solaire, en circuit fermé et ouvert, ont permis la détermination des performances thermiques du capteur à travers l’estimation de la constante de temps et du rendement journalier. Les tests ont été effectués durant la journée type du mois de Juillet, ainsi que durant la période d’une semaine. Les résultats des tests ont donnés une constante du temps de 5 min et un rendement journalier de 41% pour la journée du 19/07/2012.
Amélioration de la qualité de l’énergie électrique: Identification des creux de tension
Authors: Gattal Boulaares , Chikhi Khaled , Fetha Cherif
Published: December 2023

L’article présente une technique pour l’analyse des problèmes de qualité de l’énergie électrique, applicable aux creux de tension. Cette méthode représente un processus d’identification du type de creux de tension à partir des formes d’onde enregistrées. Le type de creux de tension est une caractéristique importante, car elle permet l’identification et la localisation du défaut produit.
Study of the absorption refrigerating cycle, NH3-H2O coupled with the solar absorption heat transformer, H2O-LiBr by solar data from the City of Oujda (Morocco)
Authors: Rhayt Fathi , Dezairi Aouatif , Ouaskit Said , Loulijat Hamid , Zerradi Hicham , Mizani Sofia
Published: December 2023

A solar refrigerator is made of a solar collector and a refrigeration system. This paper concerns the study of a two-stage vapour absorption cycle (heat transformer and refrigerating cycle) employing the refrigerant absorbent combinations of H2O-LiBr and NH3-H2O successively. The system consists of coupling the previous absorption cycle so that the first-stage absorber produces heating water to circulate in the generator of the second stage. It is found that the system can be operated at lower hot source temperatures and, thus, it can be supplied either from flat plate collectors.
Analyse statistique des hauteurs de la houle sur la côte du Bénin dans le Golfe de Guinée: Puissance énergétique de la houle non-linéaire dans la zone de shoaling
Authors: Houekpoheha Mathias Adjimon , Kounouhewa Basile Bruno , Hounsou Joël Toyigbé , Tokpohozin Bernard Noukpo , Awanou Cossi Norbert
Published: December 2023

La forte demande en énergie électrique, à laquelle est soumis le monde, mérite une exploration de toutes les sources d’énergies dont leur valorisation permettra de pallier à la crise énergétique. Le Bénin est un état côtier du Golfe de Guinée qui bénéficie de l’accès à l’océan, qui est le siège d’un perpétuel mouvement de vagues, sources inépuisables d’énergies renouvelables. A travers ce travail, utilisant les mesures de données liées à houle dans les eaux profondes et obtenues auprès de l’IRHOB (Institut de Recherches Halieutiques et Océanographiques du Bénin), nous avons réalisé une étude statistique des hauteurs de la houle afin de déterminer sa hauteur significative. Avec la relation de dispersion des vagues non-linéaire [1-3] et les équations de Boussinesq (Peregrine) [4, 5], nous avons caractérisé les variations des différents paramètres de la houle (hauteur, longueur d’onde, vitesse de groupe) dans la zone de shoaling sur le site d’étude et procéder à l’estimation de la variation de la puissance énergétique de la houle à travers la zone côtière. Enfin, la zone à forte puissance énergétique de ces houles est mise en évidence sur le site, la profondeur locale d’eau au point de déferlement de la houle est évaluée et les résultats obtenus ont permis de justifier le caractère très énergétique qu’acquièrent ces houles sur cette côte lorsqu’elles sont proches de la plage.
Contribution à l'étude du contrôle actif de l’écoulement autour d’un profil de pale d’éolienne
Authors: Boudis Ali , Guerri Ouahiba , Benzaoui Ahmed , Oualli Hamid
Published: December 2023

Cette étude a pour objectif l’amélioration des caractéristiques aérodynamiques d’un profil de pale d’éolienne par l’utilisation d’une technique de contrôle actif de l’écoulement. Un actionneur de jet synthétique est utilisé pour contrôler l’écoulement autour d’un profil S809 placé dans un écoulement à un nombre Reynolds Re=106. Les équations moyennées de Navier-Stockes qui régissent l’écoulement autour du profil sont résolues en calcul instationnaire dans un domaine bidimensionnel à l’aide du code Ansys Fluent 16.1.0 ©. La turbulence est prise en charge par le modèle SST k-w. Les effets de la fréquence et de l’amplitude du jet sont étudiés pour le cas d’un profil placé sous un angle d’incidence de 15.2°, le jet synthétique étant appliqué sur l’extrados à une distance égale à 0.05c à partir du bord d’attaque (c étant la corde du profil). Les résultats obtenus montrent que le contrôle par jet synthétique a un effet significatif sur les forces aérodynamiques et la structure de l’écoulement autour de la pale. Pour les paramètres de jet synthétique étudiés, la finesse du profil (ou rapport CL/CD) est améliorée de 40.59 %.
Influence des conditions environnementales et mécaniques sur le mortier de jeune âge
Authors: Chaabane Lynda Amel , Sebaibi Yahia
Published: December 2023

L’objectif de cette étude est la valorisation des déchets de carrière, lors de la taille des blocs de pierre et d’analyser le comportement du mortier au cours des périodes chaudes. Le mortier est un matériau polyvalent (ciment, sable, eau ), afin de palier au déficit de la production du ciment, qui est une préoccupation majeure de la recherche. Il faut mettre au point des liants moins coûteux tout en préservant l’environnement, l’utilisation des additions minérales, dans le mortier qui représente une voie économique rentable sachant que le ciment contient de 3 à 5 % de gypse qui sert de régulateur de prise. Le gypse qui concentre les impuretés du minerai de base, pose souvent des problèmes de stockage et de préservation de l’environnement. L’utilisation du gypse qui est un sulfate hydraté naturel de chaux (H4CaSO6) comme traitements à la chaux ou aux liants hydrauliques (ciments ou liants routiers) confèrent à ces matériaux des caractéristiques mécaniques et une insensibilité à l’eau satisfaisante. Cet article présente les résultats d’une étude expérimentale de déchets de Gypse pour la fabrication du mortier et qui a porté sur l’utilisation des matériaux locaux (sable de la carrière de Terga) de la wilaya de Ain Temouchent en Algérie et le recyclage des additions minérales de chaux de la société (Knauf Fleurus).
Optimisation du dimensionnement d’un système hybride Eolien/Diesel
Authors: Boumechta Samer , Kaabeche Abdelhamid
Published: December 2023

Actuellement, le générateur diesel est la solution technique la plus utilisée pour l’électrification des sites isolés. Néanmoins, l’accès à ces sites étant généralement long et difficile, les coûts de maintenance et d’approvisionnement en carburant sont très élevés, ainsi les émissions de gaz à effet de serre qui présentent un grand risque sur l’environnement. En conséquence, nous avons envisagé de coupler – au sein d’un système hybride – un générateur diesel avec une source d’énergie renouvelable (éolien). Cette étude se concentre sur le développement d’un modèle de dimensionnement optimal basé sur une approche itérative pour optimiser le dimensionnement des divers composants du système hybride éolien/diesel/batteries et ce, pour assurer une autonomie totale du système. Le modèle global proposé prend en considération les modèles des différents sous-systèmes constituant le générateur hybride, le modèle de la fiabilité (LPSP) et les modèles du coût de cycle de vie (TNPC), ainsi que le modèle du coût de l’énergie (LUEC). Après l’application du modèle, toutes les configurations ayant une LPSP = 0 % sont retenues. Par la suite, la configuration optimale du système est déterminée sur la base du coût minimal.
Etude expérimentale du comportement thermique d’une maison rurale à faible consommation d’énergie
Authors: Djebri Boualem , Derradji Lotfi , Boudali Errebai Farid , Amara Mohamed , Maoudj Yassine
Published: December 2023

Notre travail s’intéresse à l’étude expérimentale d’une maison rurale à faible consommation d’énergie, qui a été réalisée dans le cadre du projet MED-ENEC (Efficacité énergétique dans le secteur du bâtiment pour les pays méditerranéens). Ce travail a pour but d’étudier le comportement thermique de cette maison à faible consommation d’énergie. Pour ce faire, treize thermocouples de type K et quatre thermo-hygromètre sont installés à l’intérieur due logement pour mesurer l’humidité relative et la température de l’air, ainsi que la température des surfaces environnantes. Cinq thermocouples sont installés à l’extérieur pour connaître la température des faces externes des parois, ainsi que la température de l’air.
Steady state oscillations reduction using neural network IC-based variable step Size MPPT
Authors: Harrag Abdelghani , Bahri Hamza , Messalti Sabir
Published: December 2023

This paper deals with the development of neural network IC-based variable step size MPPT controller. The proposed neural network MPPT controller is firstly, developed in offline mode required for testing different set of neural network parameters and architectures, and used secondly in the online mode to track the output power of the PV system composed of Solarex MSX 60W PV module fed by a DC-DC boost converter drived using the proposed ANN MPPT controller. The proposed neural network MPPT controller is tested and validated using Matlab/Simulink environments. Simulation results and analysis are presented showing good performances for the proposed controller compared to the conventional fixed or variable step size algorithms.
Active solar heating system for residential building in Algeria An energetic economic and environmental investigation
Authors: Bensalem Salaheddine , Imessad Khaled , Hamidat Abderrahmane , Missoum Mohamed
Published: December 2023

In this work we used a typical single family house in Algeria as an example, the influence of building type on the energetic efficiency of an integrated solar combisystem (SCS) is determined by means of numerical simulation using TRNSYS software program. We considered two types of buildings, which have the same size and the same orientation. The first one is a low energy pilot house performed by CDER 'Centre de Développement des Energies Renouvelables' and CNERIB 'Centre National d’Etudes et Recherches Intégrées du Bâtiment' in the framework of MED-ENEC project, however, the second considered house is a virtual building; in which the walls are of the conventional type in Algeria. Based on the obtained results, it is outlined how the total system load can be decreased by adopting some solar architecture techniques. The analysis of the auxiliary energy required by the solar combi system and the average solar fraction; shows the profitability of the SCS application in Algeria, especially in the case of low energy house. Furthermore, the economic aspect and the environmental impacts of the integrated solar heating system have been investigated. The equity payback and greenhouse gas 'GHG' emissions have been estimated by means of a numerical simulation using the powerful tools of the RETScreen free software program. The obtained results showed that the equity payback is strongly dependent on the fuel used by the conventional heating system. In the case, where the heating is assured by the gasoil, the equity payback is around the half of the project lifetime. From the environmental standpoint, the solar application is entirely advantageous. In addition, the natural gas is the most favourable conventional energy resource, with a minimum yearly GHG emissions compared to electricity and gasoil.
Exploitation des digestats liquides d’origine animale pour la fertigation hors sol des plants maraîchers en Tunisie
Authors: M’Sadak Youssef , Ben M'Barek Abir
Published: December 2023

Cette étude est consacrée à l’évaluation du comportement végétatif des plants maraîchers vis-à-vis des jus de process obtenus après dilution respectivement, du digestat liquide issu d’une installation de biométhanisation rurale bovine, dénommé Jus de Process Bovin (JPB) et du digestat liquide issu d’une installation de biométhanisation industrielle avicole, appelé Jus de Process Avicole (JPA). Parmi les paramètres agronomiques étudiés, la croissance en hauteur et le flétrissement des plants ont été particulièrement suivis selon diverses dates pour les plants témoins arrosés à l’eau (sans fertigation) et pour les plants arrosés aux solutions fertilisantes considérées (avec fertigation). Le JPB dilué à raison de 75 % d’eau a montré une capacité fertilisante intéressante pour la production hors sol des plants de piment, tout en éliminant le flétrissement intégral observé avec la fertigation concentrée. Les JPA dilués ont dévoilé des pouvoirs fertilisants intéressants spécialement celui dilué au qrapport (1/150). L’analyse statistique a révélé que la différence est non significative entre la croissance des plants de tomate arrosés avec l’eau (témoin) et ceux auxquels une fertigation est appliquée par le JPA dilué. Cependant, les résultats méritent d’être considérés avec prudence, en raison de certaines anomalies végétatives relevées dans le cas des plants arrosés avec des JPA plus concentrés.
Réalisation d’un appareil de SILAR pour la déposition des nano couches des matériaux chalcogénures pour les cellules solaires
Authors: Abderrahmane Abdelkader , Kermiche Messaoud , Adjmi Samah , Zegadi Chewki
Published: December 2023

Cet article représente la réalisation d’un appareillage fonctionnant automatiquement pour l'élaboration des nano couches par la technique 'Successive Ionic Layer Adsorption and Reaction', SILAR–Successive Adsorption Ionique des Couches et Réaction–. La technique SILAR est une technique innovante et économique. Elle consiste à l’immersion successive d’un substrat dans des solutions de composés hydrolysables. Dans ce contexte, nous avons réussi à l’élaboration de plusieurs composés qui sont utilisés dans la construction des cellules solaires. Nos résultats montrent que les couches minces obtenues sont homogènes et uniformes, leurs épaisseurs peuvent être contrôlés avec précision de quelques nanomètres. L’appareil fabriqué est prometteur et fiable pour l’application dans le domaine des couches minces pour cellules solaires.
A REVIEW ON INTEGRATION OF ELECTRIC VEHICLES AND OPTIMAL POWER MANAGEMENT STRATEGY FOR SUSTAINABLE DEVELOPMENT
Authors: Dasireddy Honey , Manoj Vasupalli , Sai Tharun Gadagamma , Harika Cheemala
Published: December 2023

The integration of electric vehicles (EVs) into our transportation system is a pivotal step towards sustainable development. EVs are gaining traction as a cleaner and more energy-efficient alternative to traditional internal combustion engine vehicles. Their adoption holds the promise of reducing greenhouse gas emissions and decreasing our reliance on fossil fuels, contributing significantly to environmental sustainability .One of the critical aspects of effective EV integration is the development and implementation of optimal power management strategies. These strategies play a pivotal role in ensuring that the charging and discharging of EV batteries are not only efficient but also seamlessly integrated with the existing power grid infrastructure. An optimal power management system takes into consideration factors such as load balancing, peak demand management, and the integration of renewable energy sources, making it a key component of a sustainable and resilient energy ecosystem. By efficiently scheduling when and how EVs charge or discharge, these strategies can reduce the strain on the electrical grid during peak periods, lower electricity costs, and minimize the carbon footprint associated with charging. Moreover, they can contribute to grid stability and reliability, making the entire energy system more sustainable. This research explores the synergistic potential of EVs and smart grid technologies, aiming to create a harmonious relationship between transportation and energy systems. Key Words: Electric Vehicles, Sustainable Development, Optimal Power Management, greenhouse gas emissions, fossil fuels, clean environment, smart grid technology.
Görüntü İşleme Tekniklerini Kullanarak Mobil Uygulama Tabanlı Optik Okuyucu Sisteminin Geliştirilmesi
Authors: TURHAN Sercan , BOZKURT Mert , ŞAHİN Durmuş Özkan
Published: December 2023

Ülkemiz eğitim sisteminde sınavlar önemli bir yere sahiptir. Bu sınavlar genellikle çoktan seçmeli sınavlar olarak uygulanmaktadır. Çoktan seçmeli sınavlar optik form ile daha hızlı okunabilmektedir. Optik formlar zamandan tasarruf sağlarlar ancak bunun yanında bazı dezavantajlarda mevcuttur. Bunların en başında optik okuyucu cihazlarının maliyetinin yüksek olması gelmektedir. Yüksek maliyete sahip optik okuyucu cihazları her eğitim kurumunda bulunmamaktadır. Bu projede bunun önüne geçmek için bu çalışmayla birlikte önerilen mobil optik okuyucu uygulamasının alt yapısı ve geliştirme adımlarına değinilecektir. Önerilen mobil optik okuyucu uygulaması ile eğitimciler telefonlarını kullanarak optik formları okutma imkânına kavuşacaklardır. Bu sayede optik okuyucu cihazına gerek kalmamaktadır. Telefon kamerası yardımıyla okunan optik formlar çeşitli görüntü işleme teknikleriyle uygun formata getirilmektedir. Uygun formata gelen görüntüler üzerinden işaretli şıkların tanınması sağlanır. Tanınan şıkların konumlarından elde edilen soru sırası bilgisi ile sınav sonuçları hesaplanmaktadır. Sınav sonuçları değerlendirilerek öğretmen ve öğrenciye istatiksel veriler sunulmaktadır. Bu uygulamanın alt yapısında görüntü işleme teknikleri için Python OpenCV kütüphanesinden yararlanılmaktadır. Önerilen uygulama Dart ve Flutter programlama dilleri ile geliştirilmektedir. Bu programlama dilleri çapraz platformda çalışma imkânı sağlamaktadır. Bu sayede işletim sisteminden bağımsız birçok mobil cihazlar üzerinde verimli bir şekilde kullanımı sağlanacaktır. Bu gibi katkıların yanında geliştirilen uygulama test sınavlarının sonuçlarını yüksek bir oranda doğru hesaplamaktadır. Yapılan deneyler incelendiğinde hesaplama başarımı %90 ile %95 arasında ölçülmektedir. Doğru ışığın sağlanarak optik formların sisteme verilmesi halinde test sınavlarının sonuçları yüksek oranda doğru çıkmaktadır.
PHYTOCHEMICAL SCREENING, GAS CHROMATOGRAPHY-MASS SPECTROMETRY, AND IN VITRO ANTIOXIDANT POTENTIAL OF DRYOPTERIS MARGINALIS
Authors: Gupta Akhil , Sharma Rakesh , Kumar Neeraj , Bansal Mayank
Published: December 2023

The leaves of the plant Dryopteris marginalis collected from Kumaon District, Nainital India, were analyzed for the presence of different phytochemicals. The aim of this study is to screen the biologically active compounds; alkaloids, glycosides, tannins, flavonoids, steroids, saponins, phenolic compounds, fat and oils, reducing and non-reducing sugar and amino acids. Phytochemical screening indicated the presence of flavonoids, phenolic compounds, steroids, saponins, alkaloids, amino acids, volatile oils, reducing and hexose sugar. The phytochemical composition of the leaves of the plants indicates their medicinal properties.
MICROTENSILE BOND STRENGTH OF UNIVERSAL ADHESIVE TO DENTIN AFTER ER: YAG LASER PRETREATMENT WITH DIFFERENT CONDITIONING MODES - AN IN VITRO STUDY
Authors: Swathisha Annie , Kumar N Kiran , Naik Savitha B , HS Preetham , V Shylaja
Published: December 2023

Adhesion to dentin remains challenging due to its complex nature that prevents complete infiltration of hydrophobic monomer to hydrophilic dentinal substrate. Recently, Er:YAG laser has been used in dentin pretreatment to enhance the bond strength. A deficient hybrid layer is formed following laser etching as it causes thermal damage and collagen denaturation of dentinal substrate. As the results are controversial, attempts are made to modify laser etching technique with respect to energy density, pulse duration and water spray. Thus, the present study aimed to evaluate the influence of Er:YAG laser conditioning of dentin by activation of Chlorhexidine collagen stabilising agent on the bond strength. Samples included 60 freshly extracted premolar which were divided into three groups (n=20) based on the protocol of dentin pretreatment done: Group 1 (Control) - Phosphoric acid etching followed by universal adhesive; Group 2 (Experimental) - Conventional Er:YAG laser dentioning; Group3 (Experimental) - Er:YAG laser dentin conditioning with coronal reservoir of 0.12% Chlorhexidine. Occlusal class 1 cavity was prepared on the samples followed by which dentin conditioning protocol was carried out for the respective groups. Universal adhesive was applied followed by Composite resin restoration. 1000 cycles of Thermocycling was done and the samples were sectioned to obtain microsections. Microtensile bond strength values were obtained by subjecting the specimens to Universal testing machine.Highest microtensile bond strength value was obtained for group 1 followed by group 3 with least value obtained for Group2 with statistically significant values between the groups. (p<0.0001). Within the limitations of the present invitro study, it can be concluded that preetching with phosphoric acid increases the bond strength of universal adhesive to dentin. Laser conditioning of dentin through activation of chlorhexidine provided better bond strength value of universal adhesive when compared to conventional laser dentin conditioning.
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE, 3-HYDROXY-4-(3-HYDROXY BENZYLIDENE AMINO) BENZOIC ACID AND THEIR Ni(II) AND Zn(II) METAL COMPLEXES
Authors: Kalluru Seshaiah , Dammu Lakshmi Kanthamma , Nara  Sathish Kumar , Nimmagadda Venkata Vijaya Jyothi
Published: December 2023

A Schiff base, 3-Hydroxy-4-(3-hydroxy benzylidene amino) benzoic acid was synthesized from the corresponding startingketone, 3-Hydroxy benzaldehyde and amine, 3-hydroxy 4-amino benzoic acid by condensation reaction. Further, themetal complexes of the Schiff base with Ni(II) and Zn(II) were synthesized. These Schiff base and its Ni(II) and Zn(II)metal complexes were characterized by spectral techniques like FT-IR, 1H NMR and 13C NMR spectroscopy. Thesynthesized compounds were evaluated for their antibacterial activity against Gram positive and negative bacteria likeStaphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The anti-fungal activities were also studiedfor Candida albicans, Candida parapsilosis. The Zn(II) metal complex exhibited the good antibacterial and antifungal activityamong the all prepared compounds.
PRODUCTION OF LACCASE FROM GANODERMA SP. BY USING AGRO-RESIDUAL WASTES
Authors: M Shailaja , B.M. Anusha Aradhya , Vantamuri Adiveppa B.
Published: December 2023

Solid-state fermentation (SSF) has emerged as a potential technology for the production of microbial products such asfeed, fuel, food, industrial chemicals and pharmaceutical products. Its application in bioprocesses such as bioleaching, biobeneficiation, bioremediation, biopulping, etc. has offered several advantages. Utilisation of agro-industrial residues assubstrates in SSF processes provides an alternative avenue and value-addition to these otherwise under- or non-utilisedresidues. The aim of this study was to determine the most promising fungus, the best solid substrate and the optimalconditions for the production of laccase. A laccase producing fungus Ganoderma sp. was isolated and produces laccase byutilizing the agro-wastes. The study revealed that the rice bran was found to be the best supported lignocellulosicsubstrate for extracellular laccase production under SSF and optimum condition for highest lacacse activity of pH andtemperature were observed at 6.0 and 45°C respectively. The incubation periods for laccase maximum activity was at 8thday. Glucose and Peptone were the best supported carbon and nitrogen source for the maximum laccase activity.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF LENALIDOMIDE AND ITS IMPURITIES IN SOLID DOSAGE FORM
Authors: Sitamahalakshmi D.S.V.N. , Bharath P. , Ramachandran D. , Ramamurty D.S.V.N.M.
Published: December 2023

Highly sensitive RP-HPLC method has been developed for the determination and quantification of Lenalidomideimpurities in Lenalidomide liquid dosage formulations. Samples are analysed by means of reverse phase (RP-HPLC) usingstationary phase an Inertsil ODS-3V (150 x 4.6 mm, 3μm) and the mobile phase consists of two channels A and B;channel-A: pH 3.0 phosphate buffer and channel-B: Acetonitrile: water (90:10 v/v). The flow rate was 1.0 mL/min.The column temperature was maintained at 40°C and sample cooler temperature was maintained at 5°C, injectionvolume 20 μL and wavelength 210 nm. The developed HPLC method was validated with respect to specificity,precision, linearity, accuracy, solution stability and filter study. Validation study was compared as per ICH guideline.
Multiple Linear Regression Analysis of HIV Drug of Protease Inhibitor
Authors: Singh A K , Kalhans M B , Singh N B
Published: December 2023

HIV-1 protease, because of its sensitive and essential function, is an excellent target for the drug therapy. The primary chain of an aspartic protease has two different Asp-Thr-Gly sequences. The MLR approach attempts to identify and quantify the physicochemical properties of the drug and to see whether any of these properties has any effect on drug’s biological activity. In present study 15 protease derivatives have been used as study material and on the basis of MLR equation their activity has been predicted.
IMPACT OF TRIAZOPHOS, CHEMICAL USED IN SOYBEAN CROP, ON THE GROWTH AND REPRODUCTION OF EISENIA FETIDA
Authors: KHUNTETA ANAMIKA KHANDELWAL , Singh Anuradha
Published: December 2023

Earthworms are crucial for maintaining soil quality and supporting agricultural practices. Soil conditions, such as nutrients, toxicants, moisture, fertilizers, and pesticides, can impact earthworm populations, growth, and reproduction. Of particular concern is the potential negative effects of pesticides on higher ecological levels. This study aims to evaluate the toxicity of Triazophos, a commonly used insecticide during Soybean cultivation, on the earthworm species Eisenia fetida in Kota, Rajasthan, India. In this experiment, five sets of 10 earthworms were exposed to concentrations of Triazophos ranging from 0.158 to 15.8 mg/kg dry weight, while one set served as the control. The growth of earthworms was monitored after four weeks, and the number of juveniles was counted after eight weeks. The results showed that the growth rate and reproduction of Eisenia fetida were significantly reduced by exposure to Triazophos. These findings highlight the potential ecological risks associated with the use of Triazophos in agricultural settings.
GREEN-SYNTHESIS OF SILVER NANOPARTICLES: SPECTRAL, OPTICAL, AND ANTIBACTERIAL CHARACTERIZATION STUDIES
Authors: ALBERT HELEN MERINA , S Johnson Retnaraj Samuel , D.S Jayalakshmi , C Alosious Gonsago
Published: December 2023

A green approach was used for synthesizing Silver-NPs by the extract of Artocarpus heterophyllus leaves. The effect of Artocarpus heterophyllus leaf extract was investigated. A powder XRD study has been used to analyze the structure and particle size of as-synthesized Ag-NPs. According to the powder-XRD study, the as-prepared Silver-NPs possess an FCC structure and have a particle size of 23nm. The possible bio-reducing agents within the leaf extracts were confirmed using FTIR spectral analysis. The characteristic surface plasmon resonance signal of the as-synthesized silver nanoparticles was detected at 418 nm using UV–Vis spectroscopic analysis between the wavelength range of 300 and 800nm. An emission peak was observed at 472nm in the PL investigation, indicating the fluorescent emission of Ag-NPs. The FESEM analysis has been exploited to inspect the morphological aspect of biosynthesized silver-NPs. According to FESEM micrographs, the biosynthesized NPs were found to have spherical shapes. Using the agar-well process, the antibacterial efficacy of biosynthesized Silver-NPs was examined. The prepared Silver-NPs exhibited a better antibacterial efficacy against E.coli than against S.typhi. It's also been observed that when the concentration increased, the antibacterial activity increased as well.
TRANSDERMAL DELIVERY OF DRUGS USING TRANSFEROSOMES: A COMPREHENSIVE REVIEW
Authors: Muthangi Sanjana , Pallerla Praneetha , Nimmagadda Srinivas
Published: December 2023

Transdermal delivery systems have gained popularity as a non-invasive method of drug administration that offers severaladvantages over other routes of drug delivery. They are noninvasive and self-administered delivery system whichimproves patient compliance and provide a controlled release of the drug. The greatest challenge of transdermal deliverysystems is that in which the outermost layer of skin acts as a barrier function for transfer of therapeutic agent into thebody. Molecules with high molecular weights do not pass through the skin. Therefore, only a limited number of drugsare administered by this route. So encapsulating the drugs in transfersomes is one of the best approaches to overcome thisproblem. Transferosomes are lipid based vesicular drug delivery systems which have a unique composition that allowsthem to overcome the limitation of conventional drug delivery system. They are composed of phospholipids andsurfactants, which provide them with the ability to encapsulate both hydrophilic and hydrophobic drugs. They penetratethrough stratum corneum by either intracellular route or the transcellular route by the generation of natural osmoticgradient. Compared to conventional drug delivery systems, transferosomes offer several advantages like avoidance of firstpass metabolism, increasing bioavailability of drugs. Due to its high deformability it enhances the penetration of intactvesicles. Transferosomes vary from other conventional vesicles due to their softer, better adjustable and ultra deformableartificial membranes. This review summarizes the concept of transfersomes, including their structure, formationmechanism of action, different methods of preparation, advantages, limitations along with applications.
IN-SILICO ANALYSIS OF THYMOQUINONE AS AN ANTI-CANCER AGENT AGAINST CHEMORESISTANCE-ASSOCIATED PROTEINS IN OVARIAN CANCER
Authors: Tendulkar Shivani , Hattiholi Aishwarya , Dodamani S.
Published: December 2023

Thymoquinone (TQ), a polyphenol obtained from Nigella sativa plays a fundamental role in controlling homeostasis. Itpossesses anti-cancer, anti-oxidant, anti-inflammatory, and analgesic properties. Its anti-cancer properties extend tolymphoma, leukaemia, medulloblastoma, prostate, pancreatic, breast, and ovarian cancer (OvCa). OvCa is one of themost lethal malignancies worldwide having distinct symptoms and a poor prognosis. Resistance to Cisplatin (CDDP) andsubsequent reoccurrence of tumors lead to treatment failure. To tackle this, combination therapies along withpolyphenols are being studied and have been proven to enhance CDDP response. Certain proteins such as Bcl-2, Bax,STAT3, p53, and caspase-3/9 are involved in cancer progression and signaling of chemoresistance. In this study,Thymoquinone (TQ) interactions with these proteins have been observed through molecular docking. The 3D structureprediction was carried out using Phyre2 and SWISS-MODEL. The molecular docking of protein targets and TQ wasdone using the PatchDock server. The docked results were then visualized using Discovery Studio. This study helps us tounderstand the interactions between TQ and apoptotic proteins that help in the augmentation of conventional therapy.This knowledge will also help in developing a new approach and alternate therapeutic strategies using polyphenols likeTQ, even in resistant cells.
A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIBING PATTERN OF ANTIMICROBIAL AGENTS IN PATIENTS WITH INFECTIOUS DISEASES IN TERTIARY CARE HOSPITAL
Authors: Goud Gunnala Pavan Sai , Das Nihar Ranjan , Sindhuja Akula , Anusha Dodde , Yadav Ganta Praveen Kumar , . Haricharan
Published: December 2023

Antimicrobials are used to treat infectious diseases. However, antimicrobial agents are frequently prescribed in excess, which leads to antimicrobial resistance. As a result, the prescribing pattern of antimicrobial agents must be evaluated. The study included 100 patients. The study lasted 6 months in a tertiary health care hospital. This is a Prospective observational study. Among 100 patients, 51 were male and 49 were female. Most of patients were between the age group of 51- 60 and 61-70 (20%) in each group. The most frequently seen infectious diseases were LRTI (39%), UTI (25%), GE (13%), Dengue (6%), Sepsis (6%). The length of hospital stay in LRTI patients for less than 4 days was 41.04% and more than 4 days was 58.96%. The length of hospital stay in UTI patients for less than 4 days was 44% and more than 4 days was 56%. The most common antibiotics used were Cefoperazone-Sulbactam (25.49%) followed by Ceftriaxone (21.38%) and Oseltamivir (10.98%).

In Lower Respiratory Tract Infection (LRTI) the most commonly used antimicrobial agents are Ceftriaxone (25.92%) and Oseltamivir (20.98%). In Urinary Tract Infection (UTI) the most commonly used antimicrobial agent is Cefoperazone-Sulbactam (48.29%). Ceftriaxone (22.72%) and Cefpodoxime (9.09%) are used for the treatment of Gastroenteritis (GE).
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC FOR AMLODIPINE BESYLATE AND LISINOPRIL IN COMBINED TABLET DOSAGE FORM BY USING SIMULTANEOUS ESTIMATION METHOD
Authors: Shelke Sayli , Patil Bhagyashri , Kukade Vikesh , Chandrakantkewari Chandrakantkewari
Published: December 2023

The purpose of this study was to develop and validate a simple, sensitive, accurate, and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method for simultaneous estimation of amlodipine besylate and lisinopril in a Tablet dosage form. The chromatographic measurement was performed on a Phenomenex C18 (250 × 4.6 mm, 5um) column with an optimised Acetate buffer mobile phase: Methanol (65:35). The flow rate was one ml/min, and the detecting wavelength was 221 nm. Triethanolamine was used to adjust the pH to 5. In the concentration range of 4-20 ug/ml, amlodipine besylate and lisinopril showed a linear response of the suggested approach. The correlation coefficients ('r' values) for amlodipine besylate and lisinopril were 0.9998 and 0.9995, respectively, and the retention times were 3.279 for amlodipine besylate and 6.124 for lisinopril, respectively. The developed chromatographic technique was validated for specificity, linearity, precision, accuracy, LOD, and LOQ using ICH Q2(R1) criteria. The analysis results have been validated in accordance to ICH guidelines
Dr DEVELOPMENT OF POSACONAZOLE DELAYED RELEASE FORMULATION FOR MUCORMYCOSIS BY HOT MELT EXTRUSION USING QBD APPROACH
Authors: Pandav Tisha , Devare Tejal , Pant Pankaj , Devare Tejal , Mali Ashwin
Published: December 2023

Amorphous solid dispersion (ASD) by hot-melt extrusion (HME) is an industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical actives. The creation of HME-based ASDs was significantly impacted by the implementation of Quality by Design (QbD). The objective of the study was to develop an ASD of posaconazole for the effective management of mucormycosis. The impact of change in levels of extra granular materials were identified as critical quality attributes (CQA's) for the development of delayed release tablet. A 23 full factorial design was employed to study the impact of independent variables HPMCAS (X1), HPC(X2) and CCS (X3) as CQA’s on the dependent variables such as hardness (Y1) and Disintegration Time (Y2) and % Drug release (Y3). The design was analyzed by using ANOVA by using MINITAB software. The influence of the extra granular components on the dissolution of tablet was closely evaluated while finalizing the optimized batch. The extrudes were also evaluated by FTIR, XRD and DSC analysis which confirmed the purity and in-situ conversion from crystalline to amorphous form ofthe drug. Systematic development of a bioavailable and stable ASD of posaconazole was achieved by studying the CQA’s at different levels by using the QbD and from the stability data, the optimized batch F4 was found to be stable up to 3 months at accelerated conditions40°C/75%Rh.
ISOLATION AND IDENTIFICATION OF INDIGENOUS PROBIOTICS FROM DAIRY PRODUCTS AND HUMAN BREAST MILK
Authors: G Sumalata , M Shiva Prakash
Published: December 2023

Probiotics are live microbes that beneficially affect the human and many studies have proved their promising role as safe and natural therapeutics. The isolation of probiotics from indigenous sources may develop a new way to improved probiotic strains with precious medical relevance for human benefits. Hence the aim of the present study is to isolate probiotics from locally available various dairy products (Viz. raw milk of cow and buffalo and traditional homemade curds) and human breast milk and to identify them upto species level. A total of about 80 samples from human breast milk (n=30) and dairy products (n=50) were collected aseptically and screened for the probiotic microflora using standard microbiological methods. The colonies suspected for probiotics were picked up for morphological and biochemical identification which were further confirmed by molecular methods and application of bioinformatics. The preliminary results showed several different microflora viz. Streptococcus, Staphylococcus, Lactobacillus, Diplococcus, etc. About twelve (12) isolates were further confirmed to be of different species belonging to the Genus Lactobacillus. Therefore dairy products and human breast milk are considered as suitable natural sources for probiotic microorganisms especially Lactobacillus spp., which are reported to show beneficial effects in humans.
D-SELI: Proposal for a Distributed Educational Blockchain Network with IPFS
Authors: Boghosian Reyna Der , Motz Regina
Published: December 2023

In recent years, there has been an increase in the use of blockchain networks in the educational field, with projects such as SELI (Smart Ecosystem for Learning and Inclusion) that have developed blockchain networks to exchange academic certificates and resources. However, storage space is limited in the use of blockchain networks since all transactions are stored in each node, which can lead to space and accessibility problems in centralized blockchain networks. To address this problem, this article proposes modifying the SELI educational blockchain network through the Interdisciplinary File System (IPFS) protocol in a fully distributed blockchain network, D-SELI. The D-SELI proposal seeks to solve the limitation of storage space and accessibility in blockchain networks by incorporating the IPFS protocol. IPFS is a distributed file system that uses a peer-to-peer network to store and share content decentralized, overcoming storage problems on a blockchain network. Implementing IPFS in D-SELI allows educational resources and certificates to be stored in a decentralized manner, eliminating the need to keep all transactions on each node in the network, which reduces the storage load on the nodes and improves accessibility to the data. Furthermore, being a wholly distributed network, data location problems present in centralized blockchain networks are overcome. In summary, this article presents a proposal to modify the SELI educational blockchain network through the use of the IPFS protocol in a fully distributed network (D-SELI) to solve the limitation of storage space and accessibility in blockchain networks, improve the efficiency and scalability of the network in the educational field.
Evaluation of the E-Kinerja Application Implementation Policy at the Pamong Praja Police Unit Office of Kuningan District
Authors: Zulvie Syifha
Published: December 2023

The delegation of authority from the Central Government to Regional Governments plays a crucial role in expediting Bureaucratic Reform. One facet of this reform is the adoption of the E-Kinerja application across all Regional Work Units, prompted by employees deviating from their assigned duties and functions. Consequently, the work outcomes lack effectiveness, efficiency, transparency, and accountability. This research aims to assess the E-Kinerja application's implementation at the Kuningan Regency Civil Service Police Unit Office, identifying supporting and hindering factors and exploring strategies to overcome obstacles. Utilizing a case study method with a descriptive qualitative approach, key informants, including the Head of the Kuningan Regency Civil Service Police Unit, and supporting informants from various State Civil Apparatus, were interviewed. Findings indicate that some dimensions, such as Capability (Timeliness), Efficiency (Policy Process Efforts), Responsiveness (Apparatus and Leader Response), and Accuracy (Impact for the Agency and Government), are relatively optimal. However, certain dimensions, including Effectiveness (Ability), Efficiency (Policy Implementation Process), Adequacy (Human and Non-Human Resources), and Equity (Goal Achievement and Transparency), fall short of optimal performance. Understanding the extent of the E-Kinerja application's implementation at the Kuningan Regency Civil Service Police Unit Office is crucial for refining the reform process. Addressing deficiencies in the identified dimensions will be instrumental in enhancing the overall effectiveness and efficiency of bureaucratic functions, aligning with the broader objectives of Bureaucratic Reform.
Current Study Concerning Parental Authority to Educate Children Reviewed Against the Provisions of the Child Protection Law in the Modern Era
Authors: Zakaria Taufan , Santiago Faisal
Published: December 2023

This research examines the current authority of parents in educating children, with a focus on the provisions of the Child Protection Law in the modern era. The research method was carried out through text analysis and literature studies related to legal provisions relating to the role of parents in educating children. At the discussion stage, the research identified the dynamics of parental authority involving aspects of children's freedom, human rights, and socio-cultural changes in the modern era. This study examines the concepts of appropriateness and relevance of the provisions of the Child Protection Law in accommodating the needs and rights of children to receive a balanced and quality education. Article 1 paragraph (1) of the Child Protection Law (No. 35 of 2014) states that children have the right to protection, care, and self-development so that they can live, grow, and develop optimally. The research results show that a deep understanding of these articles is crucial for maintaining a balance between children's rights and parental authority in the dynamic modern era. This research contributes to legal and educational literature, by presenting the latest views regarding the role of parents in educating children amidst the changing dynamics of modern society. Practical implications include recommendations for improving understanding and implementation of legal provisions, as well as educational approaches that support children's participation in their educational process.
Reviewer Acknowledgements for International Journal of Business and Management, Vol. 18 No. 6
Authors: Lee Stephen
Published: December 2023

Reviewer Acknowledgements for International Journal of Business and Management, Vol. 18 No. 6， 2023