bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of rSpike Protein by Specific Antibodies with Screen-Printed Carbon Electrode Modified by Electrodeposited Gold Nanostructures
Authors: Drobysh Maryia , Liustrovaite Viktorija , Baradoke Ausra , Viter Roman , Chen Chien-Fu , Ramanavicius Arunas , Ramanaviciene Almira
Published: August 2022

In this research, we assessed the applicability of electrochemical sensing techniques for detecting specific antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins in the blood serum of patient samples following coronavirus disease 2019 (COVID-19). Herein, screen-printed carbon electrodes (SPCE) with electrodeposited gold nanostructures (AuNS) were modified with L-Cysteine for further covalent immobilization of recombinant SARS-CoV-2 spike proteins (rSpike). The affinity interactions of the rSpike protein with specific antibodies against this protein (anti-rSpike) were assessed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. It was revealed that the SPCE electroactive surface area increased from 1.49 ± 0.02 cm2 to 1.82 ± 0.01 cm2 when AuNS were electrodeposited, and the value of the heterogeneous electron transfer rate constant (k0) changed from 6.30 × 10−5 to 14.56 × 10−5. The performance of the developed electrochemical immunosensor was evaluated by calculating the limit of detection and limit of quantification, giving values of 0.27 nM and 0.81 nM for CV and 0.14 nM and 0.42 nM for DPV. Furthermore, a specificity test was performed with a solution of antibodies against bovine serum albumin as the control aliquot, which was used to assess nonspecific binding, and this evaluation revealed that the developed rSpike-based sensor exhibits low nonspecific binding towards anti-rSpike antibodies.
Creativity, Eye-Movement Abnormalities, and Aesthetic Appreciation of Magritte’s Paintings
Authors: Ward Lindsey M , Kapoula Zoi
Published: August 2022

Dyslexic children have been shown to be more creative than their non-dyslexic counterparts. They have also been shown to have an abnormal oculomotor profile while viewing targets in free space, making vergence or saccadic eye movements while reading or when viewing Op art. They show a slower deceleration of their eye movements and a difficulty in coordinating their two eyes to obtain single fused vision in depth. Interestingly, their abnormal oculo-motor profile is exacerbated while reading more difficult texts. Given these differences, we postulate that dyslexics’ increased creativity may be related to their different eye movement control affecting how they perceive the world. Therefore, we decided to measure adolescent dyslexics’ creativity, oculomotor profile, and subjective responses while they viewed three paintings by Magritte. These were chosen to stimulate the perception of hidden conceptual spaces or stimulate conflict between the perception of the figural and textural content. For the first time to our knowledge, dyslexic adolescents were demonstrated to be more creative in terms of flexibility and fluidity than their non-dyslexic peers. Subjectively, while viewing the Magritte paintings, dyslexics reported fewer conceptual spaces and fewer hidden words than their non-dyslexic peers; thus, they confabulated less than non-dyslexics. Dyslexics also demonstrated an abnormal oculomotor profile similar to those that we have shown when reading, viewing randomized targets, and while perceiving illusions of depth in Op art paintings, in that they demonstrated difficulty with disconjugation and abnormalities in their eye velocity profiles. We propose there may be a link between dyslexic increased creativity and their eye movement abnormalities. Similar to reading nonsense text, we propose that Magritte’s contradictory paintings exacerbate dyslexics’ eye movement abnormalities. These eye movement abnormalities while viewing these particular paintings might provide a physiological signature suggesting a contribution of their unusual eye control to their higher creativity scores.
Resting-State Functional Connectivity Analyses: Brain Functional Reorganization in a Rat Model of Postherpetic Neuralgia
Authors: Han Shuting , Wu Guanzuan , Wei Xiang , Meng Xiaowen , Zang Fengchao , Shen Lan , Dai Hui , Wang Lina , Li Yonggang
Published: August 2022

Postherpetic neuralgia (PHN) is a chronic neuropathic pain syndrome, similar to other chronic pains, the mechanisms of which are not fully understood. To further understand the neural mechanism of this chronic pain and its transition, we performed functional magnetic resonance imaging (fMRI) scans on PHN rat models. Twelve PHN rat models were established by intraperitoneal injection of resiniferatoxin, with an additional 12 rats serving as controls. Nociceptive behavioral tests were performed on these rats and fMRI scans were performed on days 7 and 14 after modeling. Functional connection (FC) analysis was used to investigate the brain FC alterations associated with chronic pain in PHN rats, with the anterior cingulate cortex (ACC) as a seed. Nociceptive behavioral tests showed that PHN rats presented symptoms similar to those of PHN patients. FC analysis showed that compared to the control group, the PHN group showed different FC patterns on days 7 and 14. As can be seen, the brain FC alterations in the rat model of PHN changed dynamically, shifting from brain regions processing sensory information to regions processing emotions and motives.
Age-Related Variance in Performance versus Ratings of Attention and Impulse Regulation in Children: Implications for the Assessment of ADHD
Authors: Lyon Rachael E. , Rizeq Jala , Flora David B. , Martinussen Rhonda , Andrade Brendan F. , Toplak Maggie E.
Published: August 2022

Executive function task (EF) deficits are hypothesized to underlie difficulties with self-regulation. However, tasks assessing EF impairments have only been weakly correlated with rating scales that index self-regulation difficulties. A community sample of children and youth aged between 8 and 20 years old were assessed longitudinally. Growth curve analyses and correlations were conducted to better understand how these two types of measures relate to one another across development, as well as the impact of age-related variance. EF was assessed using the Stroop Task and Trail Making test and behavioral ratings of self-regulation were captured using the SWAN scale. EF task performance improved steeply until age 14–15, whereas the SWAN Scale showed small age-related decreases. EF task performance was moderately correlated with age among 8–13-year-olds and to a lesser extent among 14–20-year-olds. SWAN scores were not significantly related to age in either group. Correlations were similar in an ADHD “at-risk” subgroup. EF task performance and parent ratings of attention regulation have different developmental trajectories, which may partly explain why correlations are low to modest in these samples. In particular, age-related variance is an important methodological consideration with significant implications for the assessment of self-regulation in children and youth with ADHD.
Vibration-Reduction Strategy for High-Rise Braced Frame Using Viscoelastic-Yielding Compounded BRB
Authors: Zhou Xiangzi , Sun Tianshu , Sun Baoyin , Ma Ning , Ou Jinping
Published: August 2022

A buckling-restrained brace (BRB) serves as a typical load-bearing and energy-dissipative device for the passive control of structures under seismic loading. A BRB is generally designed to not yield under frequently occurring earthquake (FOE) and wind loads, resulting in it having less effectiveness in vibration reduction compared with post-yielding performance. To address this dilemma, this study proposed the concept and technique details of the viscoelastic-yielding compounded BRB (VBRB). Different from a conventional BRB, a VBRB is fabricated by attaching the viscoelastic damper (VED) to the surface of a BRB’s steel casing, ensuring a compatible deformation pattern between the VED and the BRB’s steel core. A dynamic loading test of VBRB specimens was carried out in which 0.2 Hz~0.6 Hz in loading rate and a maximum of 550 kN in load-bearing capacity had been applied, verifying the feasibility and performance of the VBRB. Subsequently, a parametric design procedure was developed to determine the required VBRB parameters so that the maximum elastic drift response of the structure could be reduced to the code-prescriptive value. The wind-resistance and seismic performances of the VBRB were critically evaluated through dynamic time-history analyses on a 48-story mega VBRB-equipped frame designed according to the Chinese seismic design code (GB50011-2010), and the effectiveness of the approach was also verified. Results indicate that the VBRB has advantages over a conventional BRB by providing a multi-stage passive energy dissipation capacity, resulting in a better vibration-control effect than conventional BRBs for structures subjected to wind load and seismic excitations.
One-Pot Synthesis of Pyrite Nanoplates Supported on Chitosan Hydrochar as Fenton Catalysts for Organics Removal from Water
Authors: Sun Aojie , Zhao Hanyi , Wang Mengya , Ma Jianqing , Jin Huixia , Zhang Kefeng
Published: August 2022

The Fenton reaction is a powerful method for removing refractory pollutants from water, yet it is restricted by shortcomings such as pH adjustments and generation of iron-containing sludge. In this study, a highly dispersed pyrite nanoplate supported on chitosan hydrochar was prepared through a simple one-pot hydrothermal method. The interactions between chitosan and Fe3+ suppressed the accumulation of FeS2 in the crystal growth period and led to the formation of pyrite nanoplates with many exposed (210) facets. Thus, it showed excellent Fenton-like activity and the removal efficiency of AR 73 reached 99.9% within 60 min. The catalyst could be used in a wide pH range of 3~10. Hydroxyl radicals are the main reactive oxygen species in this catalytic system. The self-reduction of generated Fe(III) species by sulfur via inner electron transfer promoted the Fe(II)/Fe(III) redox cycle, and the presence of graphene facilitated the adsorption of pollutants. This catalyst also showed good reuse performances as well as stability, which has promising prospects for practical use in wastewater treatment.
Diploid Wheats: Are They Less Immunogenic for Non-Celiac Wheat Sensitive Consumers?
Authors: Rotondi Aufiero Vera , Sapone Anna , Mazzarella Giuseppe
Published: August 2022

Non-celiac wheat sensitivity (NCWS) is a clinical entity induced by the ingestion of gluten that leads to intestinal and/or extraintestinal symptoms, and is diagnosed when celiac disease and wheat allergy have been ruled out. In addition to gluten, other grains’ components, including amylase trypsin inhibitors (ATIs) and fermentable short-chain carbohydrates (FODMAPs), may trigger symptoms in NCWS subjects. Several studies suggest that, compared with tetraploid and hexaploid modern wheats, ancient diploid wheats species could possess a lower immunogenicity for subjects suffering from NCWS. This review aims to discuss available evidence related to the immunological features of diploid wheats compared to common wheats, and at outlining new dietary opportunities for NCWS subjects.
Reduction in the Migration Activity of Microglia Treated with Silica-Coated Magnetic Nanoparticles and their Recovery Using Citrate
Authors: Shin Tae Hwan , Lee Da Yeon , Jang Yong Eun , Kwon Do Hyeon , Hwang Ji Su , Kim Seok Gi , Seo Chan , Paik Man Jeong , Lee Ju Yeon , Kim Jin Young , Park Seokho , Choi Sung-E , Basith Shaherin , Kim Myeong Ok , Lee Gwang
Published: August 2022

Nanoparticles have garnered significant interest in neurological research in recent years owing to their efficient penetration of the blood–brain barrier (BBB). However, significant concerns are associated with their harmful effects, including those related to the immune response mediated by microglia, the resident immune cells in the brain, which are exposed to nanoparticles. We analysed the cytotoxic effects of silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate dye [MNPs@SiO2(RITC)] in a BV2 microglial cell line using systems toxicological analysis. We performed the invasion assay and the exocytosis assay and transcriptomics, proteomics, metabolomics, and integrated triple-omics analysis, generating a single network using a machine learning algorithm. The results highlight alteration in the mechanisms of the nanotoxic effects of nanoparticles using integrated omics analysis.
Golden Syrian Hamster Models for Cancer Research
Authors: Wang Zhongde , Cormier Robert T.
Published: August 2022

The golden Syrian hamster (Mesocricetus auratus) has long been a valuable rodent model of human diseases, especially infectious and metabolic diseases. Hamsters have also been valuable models of several chemically induced cancers such as the DMBA-induced oral cheek pouch cancer model. Recently, with the application of CRISPR/Cas9 genetic engineering technology, hamsters can now be gene targeted as readily as mouse models. This review describes the phenotypes of three gene-targeted knockout (KO) hamster cancer models, TP53, KCNQ1, and IL2RG. Notably, these hamster models demonstrate cancer phenotypes not observed in mouse KOs. In some cases, the cancers that arise in the KO hamster are similar to cancers that arise in humans, in contrast with KO mice that do not develop the cancers. An example is the development of aggressive acute myelogenous leukemia (AML) in TP53 KO hamsters. The review also presents a discussion of the relative strengths and weaknesses of mouse cancer models and hamster cancer models and argues that there are no perfect rodent models of cancer and that the genetically engineered hamster cancer models can complement mouse models and expand the suite of animal cancer models available for the development of new cancer therapies.
Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios
Authors: Chaikina Marina V. , Bulina Natalia V. , Vinokurova Olga B. , Gerasimov Konstantin B. , Prosanov Igor Yu. , Kompankov Nikolay B. , Lapina Olga B. , Papulovskiy Evgeniy S. , Ishchenko Arcady V. , Makarova Svetlana V.
Published: August 2022

Apatite is widely used in medicine as a biomaterial for bone tissue restoration. Properties of apatite depend on its composition, including the Ca/P ratio. This paper shows what range of Ca/P ratio can be attained in apatite by the mechanochemical method of synthesis, providing fast formation of a single-phase product. The synthesis was carried out from a reaction mixture of CaHPO4 and CaO at different Ca/P ratios in the range of 1.17–2.10. The products were studied by PXRD, FTIR and NMR spectroscopy, HRTEM, and STA. In mixtures with a low initial Ca/P ratio (1.17–1.48), directly in the mill, the formation of calcium orthophosphate with whitlockite structure containing an HPO42− group and structural water is shown for the first time. This phosphate has structure similar to that of whitlockites of hydrothermal origin and differs from high-temperature β-tricalcium phosphate that has composition Ca3(PO4)3. A series of samples of apatite was obtained with varied composition, which depends on the initial Ca/P ratio. At Ca/P < 1.67, the formation of two types of calcium-deficient apatite was documented. At Ca/P > 1.67, the existence of two types of calcium-rich apatite is confirmed.
The Need to Prioritize Prevention of Viral Spillover in the Anthropopandemicene: A Message to Global Health Researchers and Policymakers
Authors: Tajudeen Yusuf Amuda , Oladipo Habeebullah Jayeola , Yusuf Rashidat Onyinoyi , Oladunjoye Iyiola Olatunji , Adebayo Aminat Olaitan , Ahmed Abdulhakeem Funsho , El-Sherbini Mona Said
Published: August 2022

Increased anthropogenic activities including changes in land use and unrelenting ecosystem services related to animal husbandry, wildlife trade, and deforestation are driving the emergence of viral zoonosis. This is primarily due to human–animal interaction which is facilitating the spillover of viral zoonotic pathogens from animals (domestic and wildlife) to humans that could result in epidemics or pandemics. Scientific reports so far have revealed that viral epidemics and pandemics in recent years such as H1N1 Swine Influenza, H5N1 Avian Influenza, Ebola, Zika, Severe Acute Respiratory Syndrome (SARS), and the ongoing SARS-CoV-2 were all zoonotic, and their emergence has been linked with spillover events arising from human–animal interaction. This increased interaction and the increased spillover event could facilitate future pandemic risk, and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, “IPBES”, has declared this “the era of pandemics”. Furthermore, since future pandemics would be triggered by anthropogenic activities, we have called this “anthropopandemicene”, i.e., an era of pandemics driven by anthropogenic activities. To minimize the risk of future pandemics, it is important to prioritize the prevention of viral spillover events. Here, we outline five priority areas for global health researchers and policymakers. These areas include improvement of biosecurity at livestock farms, imposing a moratorium or strictly banning wildlife trade that poses a public health risk, conservation of biodiversity by halting deforestation, investing in community-based research for infectious disease control, and strengthening community healthcare systems in precarious ecosystems and infectious diseases hotspots. Finally, we acknowledge the efforts of other renowned global and legally binding frameworks such as IHR, the Paris Agreement, and CITES with regard to addressing the public health risk of infectious diseases, and we provide recommendations for their improvement.
Investigating Children’s Ability to Express Internal States through Narratives and Drawings: Two Longitudinal Studies during Pandemic
Authors: Vettori Giulia , Ruffini Costanza , Andreini Martina , Megli Ginevra , Fabbri Emilia , Labate Irene , Bianchi Sara , Pecini Chiara
Published: August 2022

The COVID-19 pandemic emergency has challenged children’s socio-affective and cognitive development. It is essential to capture the modulation of their emotional experience through ecological and children-friendly tasks, such as written narratives and drawings. This contribution investigates the impact of pandemic experience (2020–2021 waves) on the internal states and emotions of the primary school age children, according to a longitudinal research approach through narratives (study 1 n = 21) and drawing tasks (study 2 n = 117). 138 Italian children were examined during COVID-19 three (study 1) or two waves (study 2). Children’s written narratives were codified on the basis of narrative competence and psychological lexicon. Children’s drawings were codified based on social/emotional, physical, and environmental elements. Results of narrative texts showed a lower psychological lexicon relating to positive emotions and a greater psychological lexicon relating to negative emotions only in the study sample group during the first lockdown compared to the previous and subsequent periods. Children’s drawings of themselves showed a decrease of negative emotions during the third pandemic wave in comparison to the first pandemic wave. Results inform mental health services, school practitioners, and parents about the importance of written narratives and drawings for promoting well-being in the developmental age.
The Evolution of Microstructure for Carburizing and Quenching 17CrNiMo6 Steel: Forecasting and Experimentation
Authors: Chu Yuanzhao , Gai Dengyu , Wang Ruochen , Zhuang Zhu , Zhang Tao , Wang Shibin
Published: August 2022

This paper investigates the evolution of the microstructure of 17CrNiMo6 steel produced by carburizing and quenching through computer-aided engineering (CAE) and experimental study. The chemical composition, microstructure, and properties vary from surface to the core during the carburizing and quenching, which makes the CAE simulation of temperature field and microstructure evolution more complex. The performance–temperature and field performance–microstructure iterations using different simulation methods are applied. The results showed that the CAE forecast microstructure evolution is consistent with the experiment. The error between the predicted and experimental values from the surface to 2000 μm is 5%–9%, and the predicted results are consistent with the experiment at the depth of 2000 μm.
Macroscopic and Microstructural Features of Metal Thin-Wall Fabricated by Laser Material Deposition: A Review
Authors: Wang Xinlin , Jiang Jinkun , Xia Chengui , Yu Yang
Published: August 2022

Owing to the versatility without expanding the machine’s size, thin-wall has been widely used in high-value parts. The investigation of laser additive manufacturing (LAM), which has advantages such as high powder density, easy controllability, and excellent stability, on the fabrication of thin-wall has drawn much attention. In this paper, the research status of macroscopic and microstructural features of metal thin-wall fabricated by LAM has been reviewed. The deposition quality was mainly focused on the effect of process parameters and especially the matching of z-increment and single deposition height. Based on the grain size and growth of columnar, the characteristics of microstructures were analyzed. Considering the structural feature of thin-wall, the effect of grain size and phases on the hardness and distribution of hardness were discussed. The effect of grain size, phases and loading direction on the tensile properties were reviewed. The distribution and modification of thermal stress were presented.
Influence of Heat Treatment on the Corrosion Behavior of Electrodeposited CoCrFeMnNi High-Entropy Alloy Thin Films
Authors: Popescu Ana-Maria Julieta , Branzoi Florina , Burada Marian , Atkinson Irina , Constantin Ionut , Moreno Jose Calderon , Miculescu Florin , Mitrica Dumitru , Badea Ioana-Cristina , Olaru Mihai Tudor , Constantin Virgil
Published: August 2022

In this paper, we investigate what effects heat treatment can have on potentiodynamically electrodeposited high-entropy thin film (HEA) CoCrFeMnNi alloys. We focused our study on the corrosion resistance in synthetic seawater, corroborated with the structure and microstructure of these thin films. Thin films of HEA alloys were deposited on a copper foil substrate, using an electrolyte based on the organic system dimethyl-sulfoxide (DMSO-(CH3)2SO)-acetonitrile (AN-CH3CN) (in a volume ratio of 4:1), which contains LiClO4 as electrolyte support and chloride salts of CoCl2, CrCl3 × 6H2O, FeCl2 × 4H2O, MnCl2 × 4H2O and NiCl2 × 6H2O. Using MatCalc PC software, based on the CALPHAD method, the structure and characteristics of the HEA system were investigated, and thermodynamic and kinetic criteria were calculated. The modeling process generated in the body-centered-cubic (BCC) or face-centered-cubic (FCC) structures a series of optimal compositions that are appropriate to be used in anticorrosive and tribological applications in a marine environment. Electrochemical measurements were carried out in an aerated artificial seawater solution at ambient temperature. In the experimental media, HEA thin films proved to have good corrosion resistance and were even better than the copper substrate. Corrosion resistance was improved after heat treatment, as shown by polarization and EIS tests. The structure and microstructure of HEA thin films before and after corrosion in artificial seawater were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS). The XRD data showed no significant changes in the structure of HEA heat-treated thin films after the corrosion in saline media. The data obtained by polarization and ESI are supported by results from SEM-EDS. This complex study reveals that, for HEA thin films, heat treatment leads to an increase in corrosion resistance. So, this finding suggests that thermal annealing is an appropriate method for improving the corrosion performance of HEA thin films.
Electroless Deposits of ZnO and Hybrid ZnO/Ag Nanoparticles on Mg-Ca0.3 Alloy Surface: Multiscale Characterization
Authors: González-Murguía José Luis , Lucien Veleva , Alpuche-Avilés Mario
Published: August 2022

ZnO and hybrid of ZnO/Ag structures in the nanometer size were electroless deposited on the Mg-Ca0.3 alloy surface, achieved from aqueous solutions (10−3 M at 21 °C) of ZnO (suspension), Zn(NO3)2 and AgNO3. The surface characterization of the deposits was carried out by Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), X-Ray Photoelectron Spectroscopy (XPS), Fourier transform infrared (FTIR), UV-Visible and Raman spectroscopy. The nanoparticles (NPs) area size distribution analysis revealed that the average of ZnO-NPs was ~85 nm. Likewise, the Ag-NPs of electroless deposits had an average area size of ~100 nm and nucleated in the vicinity of ZnO-NPs as Ag+ ions have been attracted by the negatively charged O2− atoms of the Zn-O dipole. The ZnO-NPs had the wurtzite structure, as indicated by Raman spectroscopy analysis and XRD complementary analysis. The UV-Visible spectroscopy analysis gave a peak at ~320 nm associated with the decrease in the imaginary part (k) of the refractive index of Ag-NPs. On the Mg-Ca0.3 surface, MgO, Mg(OH)2 and MgCO3 are present due to the Mg-matrix. XRD spectra of Ag-NPs indicated the presence of planes arranged with the FCC hexagonal structure. The reported hybrid ZnO/Ag electroless deposits of NPs are of interest for temporary implant devices, providing antibacterial properties to Mg-Ca0.3 surface, a widely used biodegradable material.
A Novel Criticality Analysis Technique for Detecting Dynamic Disturbances in Human Gait
Authors: Eltanani Shadi , olde Scheper Tjeerd V. , Dawes Helen
Published: August 2022

The application of machine learning (ML) has made an unprecedented change in the field of medicine, showing a significant potential to automate tasks and to achieve objectives that are closer to human cognitive capabilities. Human gait, in particular, is a series of continuous metabolic interactions specific for humans. The need for an intelligent recognition of dynamic changes of gait enables physicians in clinical practice to early identify impaired gait and to reach proper decision making. Because of the underlying complexity of the biological system, it can be difficult to create an accurate detection and analysis of imbalanced gait. This paper proposes a novel Criticality Analysis (CA) methodology as a feasible method to extract the dynamic interactions involved in human gait. This allows a useful scale-free representation of multivariate dynamic data in a nonlinear representation space. To quantify the effectiveness of the CA methodology, a Support Vector Machine (SVM) algorithm is implemented in order to identify the nonlinear relationships and high-order interactions between multiple gait data variables. The gait features extracted from the CA method were used for training and testing the SVM algorithm. The simulation results of this paper show that the implemented SVM model with the support of the CA method increases the accuracy and enhances the efficiency of gait analysis to extremely high levels. Therefore, it can perform as a robust classification tool for detection of dynamic disturbances of biological data patterns and creates a tremendous opportunity for clinical diagnosis and rehabilitation.
Node Monitoring as a Fault Detection Countermeasure against Information Leakage within a RISC-V Microprocessor
Authors: Owen Donald E. , Joseph Jithin , Plusquellic Jim , Mannos Tom J. , Dziki Brian
Published: August 2022

Advanced, superscalar microprocessors (μP) are highly susceptible to wear-out failures because of their highly complex, densely packed circuit structure and extreme operational frequencies. Although many types of fault detection and mitigation strategies have been proposed, none have addressed the specific problem of detecting faults that lead to information leakage events on I/O channels of the μP. Information leakage can be defined very generally as any type of output that the executing program did not intend to produce. In this work, we restrict this definition to output that represents a security concern, and in particular, to the leakage of plaintext or encryption keys, and propose a counter-based countermeasure to detect faults that cause this type of leakage event. Fault injection (FI) experiments are carried out on two RISC-V microprocessors emulated as soft cores on a Xilinx multi-processor System-on-chip (MPSoC) FPGA. The μP designs are instrumented with a set of counters that records the number of transitions that occur on internal nodes. The transition counts are collected from all internal nodes under both fault-free and faulty conditions, and are analyzed to determine which counters provide the highest fault coverage and lowest latency for detecting leakage faults. We show that complete coverage of all leakage faults is possible using only a single counter strategically placed within the branch compare logic of the μPs.
Progress in Near-Equilibrium Ammonothermal (NEAT) Growth of GaN Substrates for GaN-on-GaN Semiconductor Devices
Authors: Hashimoto Tadao , Letts Edward R. , Key Daryl
Published: August 2022

This paper reviews the near-equilibrium ammonothermal (NEAT) growth of bulk gallium nitride (GaN) crystals and reports the evaluation of 2″ GaN substrates and 100 mmbulk GaN crystal grown in our pilot production reactor. Recent progress in oxygen reduction enabled growing NEAT GaN substrates with lower residual oxygen, coloration, and optical absorption. The oxygen concentration was approximately 2 × 1018 cm−2, and the optical absorption coefficient was 1.3 cm−1 at 450 nm. Maps of full-width half maximum (FWHM) of X-ray diffraction rocking curveswere generated for grown crystals and finished wafers. The X-ray rocking curve maps confirmed high-quality and uniform microstructure across the entire surface of the bulk crystals and substrates. The average FWHM of the 50 best bulk crystals from the recent batch was 28 ± 4 arcsec for the 002 diffraction and 34 ± 5 arcsec for the 201 diffraction, with an average radius of curvature of 20 m. X-ray topography measured on both sides of the bulk crystals implied that the density of dislocations wasreduced by one order of magnitude during the NEAT growth. A typical NEAT GaN substrate shows dislocation density of about 2 × 105 cm−2.
Influence of ZnO Morphology on the Functionalization Efficiency of Nanostructured Arrays with Hemoglobin for CO2 Capture
Authors: Mendoza-Sánchez Alberto , Cano Francisco J. , Hernández-Rodríguez Mariela , Cigarroa-Mayorga Oscar
Published: August 2022

In this study, nanostructured ZnO arrays were synthesized by an accessible thermal oxidation (TO) methodology. The Zn films were chemically etched with nitric acid (HNO3) and then oxidized in a furnace at 500 °C for 5 h. Two different morphologies were achieved by modifying the HNO3 concentration in the etching process: (a) ZnO grass-like nanostructures and (b) rod-like nanostructures, with an etching process in HNO3 solution at 2 and 8 M concentration, respectively. The physical and chemical properties of the samples were analyzed by X-ray diffraction (XRD), scanning (SEM) and transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Both morphologies were functionalized with hemoglobin, and a difference was found in the efficiency of functionalization, which was monitored by UV–Vis spectroscopy. The sample with the highest efficiency was the ZnO grass-like nanostructures. Afterward, the capture of carbon dioxide was evaluated by monitoring a sodium carbonate solution interacting with the as-functionalized samples. The evaluation was analyzed by UV–Vis spectroscopy and the results showed a CO2 capture of 98.3% and 54% in 180 min for the ZnO grass-like and rod-like nanostructures, respectively.
Vertical Distribution of Beetles (Coleoptera) in Pine Forests in Central European Russia
Authors: Ruchin Alexander B. , Egorov Leonid V. , Khapugin Anatoliy A.
Published: August 2022

Research on the Arthropoda distribution in temperate forest ecosystems has shown that communities are distributed vertically in unequal numbers. However, this issue still has research gaps in relation to the vertical stratification of Coleoptera in pine forests of the temperate zone. This study was conducted in the Republic of Mordovia situated in central part of European Russia. We used fermental traps to collect Coleoptera (the bait is fermenting beer with sugar and honey). The sampling was conducted from May to September 2021 in five sites of pine forests. One hundred and twenty-five species from 36 families were identified. The highest species richness was found in Nitidulidae and Cerambycidae (19 species each), Elateridae (13), Curculionidae (7) and Scarabaeidae (6). The highest number of species (84 species) was obtained at the height of 1.5 m, while the smallest species richness (44 species) was found at the height of 12.0 m. At the height of 12 m, we also registered the minimum number of specimens. Twenty-four species from 11 families were common to all the heights studied. Cryptarcha strigata and Glischrochilus grandis preferred heights of 3 and 1.5 m. Cryptarcha undata and Protaetia marmorata were more common at a height of 7 m with a frequency of 61.4–79.6% and 68.2–79.6%, respectively. The absolute number of saproxyl and anthophilic beetle species was higher in the ground layer and at the undergrowth level. These studies expand our understanding of the vertical distribution of beetles in pine forests of the temperate zone of European Russia.
Tuberculosis in Poland: Epidemiological and Molecular Analysis during the COVID-19 Pandemic
Authors: Borkowska-Tatar Dagmara , Zabost Anna , Kozińska Monika , Augustynowicz-Kopeć Ewa
Published: August 2022

The COVID-19 pandemic may have a negative impact on the proper implementation of TB control programmes and may increase TB incidence rates in the near future. The aim of this study was to perform an epidemiological and molecular analysis of Mycobacterium tuberculosis strains cultured from tuberculosis patients in Poland in 2020 and to compare the results of monitoring drug-resistant tuberculosis in Poland with previous studies in 2012 and 2016. The analysis was based on questionnaires and strains sent by regional laboratories during the 12 months of 2020. Molecular analysis was performed by spoligotyping 20% of the strains sensitive to the four primary antimycobacterial drugs and all of the drug-resistant strains. The number of strains sent for analysis dropped threefold, from 4136 in 2012 to 1383 in 2020. The incidence of tuberculosis among men was higher than among women. There was an increase in strains’ resistance to antimycobacterial drugs in both newly diagnosed patients, from 4.4% in 2012 to 6.1% in 2020, and previously treated patients, from 11.7% to 12.3%. Four-year resistance increased to 1% and 2.1%, respectively. The spoligotype SIT1 was the most abundant among the resistant strains (17%), and SIT53 (13.9%) was the most common among susceptible strains.
Work Conditions of Italian Nurses and Their Related Risk Factors: A Cohort Investigatory Study
Authors: Vitale Elsa
Published: August 2022

(1) Background: Nursing is a satisfying employment pathway, as nurses preserve lives, but it is also considered one of the most stressful care professions. Nursing is a lifesaving and highly satisfying profession, yet it is considered one of the most stressful occupations. This study aimed to assess differences in anxiety, depression and stress states among nurses according to gender, work history, shift and body mass index (BMI) characteristics. (2) Methods: An online questionnaire was addressed to all Italian nurses during May 2022, investigating anxiety, depression and stress conditions according to the Depression, Anxiety and Stress Scale-21 Items (DASS-21) and sampling characteristics, such as sex, work experience, shift and BMI values. (3) Results: A total of 408 Italian nurses answered the questionnaire. Significant differences between the following were reported: anxiety levels and work experience, since nurses employed over 6 years reported higher anxiety levels than their younger colleagues (p = 0.035); depression levels and sex (p = 0.017), as females reported higher depression levels than males; and also between depression levels and BMI levels (p = 0.003), as 5.90% of overweight and 2.50% of obese participants reported extremely severe depression. By considering stress levels according to sampling characteristics, significant differences were registered according to BMI levels (p < 0.001), as overweight subjects reported higher stress levels (7.40%) than the other subgroups. Finally, significant associations were recorded between anxiety, depression and stress conditions with sex, work experience, shift and BMI. (4) Conclusions: The data were in agreement with the current literature, indicating that nurses might take care not only of their patients but also of themselves, in both the physical and mental aspects.
Characterization of SIBLING Proteins in the Mineralized Tissues
Authors: Dab Sandeep , Abdelhay Nancy , Figueredo Carlos Alberto , Ganatra Seema , Gibson Monica Prasad
Published: August 2022

The SIBLING proteins are a family of non-collagenous proteins (NCPs) previously thought to be expressed only in dentin but have been demonstrated in other mineralized and non-mineralized tissues. They are believed to play vital roles in both osteogenesis and dentinogenesis. Since they are tightly regulated lifelong processes and involve a peak of mineralization, three different age groups were investigated. Fifteen wild-type (WT) mice were euthanized at ages 1, 3, and 6 months. Hematoxylin and eosin staining (H&E) was performed to localize various microscopic structures in the mice mandibles and tibias. The immunostaining pattern was compared using antibodies for dentin sialoprotein (DSP), dentin matrix protein 1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN). Immunostaining of DSP in tibia showed its most noticeable staining in the 3-month age group. DSP was expressed in alveolar bone, cellular cementum, and PDL. A similar expression of DMP1 was seen in the tibia and dentin. BSP was most noticeably detected in the tibia and acellular cementum. OPN was mainly expressed in the bone. A lower level of OPN was observed at all age groups in the teeth. The immunostaining intensity was the least detected for all proteins in the 6-month tibia sample. The expression patterns of the four SIBLING proteins showed variations in their staining intensity and temporospatial patterning concordant with skeletal and dental maturity. These findings suggest some role in this tightly regulated mineralization process.
On the Inherent Instability of Biocognition: Toward New Probability Models and Statistical Tools
Authors: Wallace Rodrick , Leonova Irina , Gochhait Saikat
Published: August 2022

A central conundrum enshrouds biocognition: almost all such phenomena are inherently unstable and must be constantly controlled by external regulatory machinery to ensure proper function, in much the same sense that blood pressure and the ‘stream of consciousness’ require persistent delicate regulation for the survival of higher organisms. Here, we derive the Data Rate Theorem of control theory that characterizes such instability via the Rate Distortion Theorem of information theory for adiabatically stationary nonergodic systems. We then outline a novel approach to building new statistical tools for data analysis based on those theorems, focusing on groupoid symmetry-breaking phase transitions characterized by Fisher Zero analogs.
Four-Objective Optimization for an Irreversible Porous Medium Cycle with Linear Variation in Working Fluid’s Specific Heat
Authors: Zang Pengchao , Chen Lingen , Ge Yanlin , Shi Shuangshuang , Feng Huijun
Published: August 2022

Considering that the specific heat of the working fluid varies linearly with its temperature, this paper applies finite time thermodynamic theory and NSGA-II to conduct thermodynamic analysis and multi-objective optimization for irreversible porous medium cycle. The effects of working fluid’s variable-specific heat characteristics, heat transfer, friction and internal irreversibility losses on cycle power density and ecological function characteristics are analyzed. The relationship between power density and ecological function versus compression ratio or thermal efficiency are obtained. When operating in the circumstances of maximum power density, the thermal efficiency of the porous medium cycle engine is higher and its size is less than when operating in the circumstances of maximum power output, and it is also more efficient when operating in the circumstances of maximum ecological function. The four objectives of dimensionless power density, dimensionless power output, thermal efficiency and dimensionless ecological function are optimized simultaneously, and the Pareto front with a set of solutions is obtained. The best results are obtained in two-objective optimization, targeting power output and thermal efficiency, which indicates that the optimal results of the multi-objective are better than that of one-objective.
Progress in Hexagonal Boron Nitride (h-BN)-Based Solid-State Neutron Detector
Authors: Hasan Samiul , Ahmad Iftikhar
Published: August 2022

This article will briefly review the progress of h-BN based solid-state metal semiconductor metal (MSM) neutron detectors. In the last decade, several groups have been working on hexagonal boron nitride (h-BN)-based solid-state neutron detectors. Recently, the detection efficiency of 59% has been reported. Efficient, low-cost neutron detectors made from readily available materials are essential for various applications. Neutron detectors are widely used to detect fissile materials and nuclear power plants for security applications. The most common and widely used neutron detectors are 3He based, which are sometimes bulky, difficult to transport, have high absorption length, need relatively high bias voltage (>1000 V), and have low Q-value (0.764 MeV). In addition, 3He is not a readily available material. Thus, there is a strong need to find an alternative detection material. The 10B isotope has a high neutron absorption cross-section, and it has been tested as a coating on the semiconducting materials. Due to the two-step process, neutron capture through 10B and then electron–hole pair generation in a typical semiconducting material, the efficiency of these devices is not up to the mark. The progress in h-BN based detectors requires a review to envision the further improvement in this technology.
A Tree Structure Protocol for Hierarchical Deterministic Latency Name Resolution System
Authors: Xie Wei , You Jiali , Wang Jinlin
Published: August 2022

Information-centric networking (ICN) shifts the communication model from a host-centric paradigm to an information-centric paradigm, and is promising for solving several problems on today’s Internet. For more efficient information dissemination, most ICN architectures are based on the Identifier/Locator split design. Therefore, how to map an identifier to a routable locator is an important problem for efficient data transmission. Nowadays, many new network services such as industrial control and telemedicine are highly latency-sensitive and require deterministic service response latency. To meet such requirements, name resolution with a deterministic latency guarantee is needed, but less discussed. This paper proposes a tree-based resolution system structure for deterministic latency resolution, which can support the Local Name Mapping Resolution System (LNMRS) in the new ICN network architecture—SEANet—to provide deterministic name resolution service in latency-sensitive scenarios like industrial control and telemedicine. The correctness of such a structure is the key to achieving deterministic latency resolution. To ensure the structure’s correctness in a distributed manner, a tree structure protocol based on delay measurement is also proposed for structure generation and maintenance. Simulation results show that the protocol is effective in generating a correct structure that has good performance in terms of service capability for deterministic name resolution and system scalability.
High-Speed Privacy Amplification Algorithm Using Cellular Automate in Quantum Key Distribution
Authors: Lu Yekai , Bai Enjian , Jiang Xue-qin , Wu Yun
Published: August 2022

Privacy amplification is an important step in the post-processing of quantum communication, which plays an indispensable role in the security of quantum key distribution systems. In this paper, we propose a Cellular Automata-based privacy amplification algorithm, which improves the speed of key distribution. The proposed algorithm is characterized by block iteration to generate secure key of arbitrary length. The core of the algorithm in this paper is to use the property that Cellular Automata can generate multiple new associated random sequences at the same time to carry out bit operations for multiple negotiation keys in the meantime and calculate in turn, so as to quickly realize the compression of negotiation keys. By analyzing the final key, the proposed algorithm has the advantages of fast key generation speed and high real-time performance. At the same time, the results of the NIST randomness test and avalanche test show that the algorithm has good randomness performance.
Is the Production of Agricultural Biogas Environmentally Friendly? Does the Structure of Consumption of First- and Second-Generation Raw Materials in Latvia and Poland Matter?
Authors: Wicki Ludwik , Naglis-Liepa Kaspars , Filipiak Tadeusz , Parzonko Andrzej , Wicka Aleksandra
Published: August 2022

The importance of biogas in the energy mix in Poland and Latvia is very low. In Poland, 306 million m3 of biogas is produced annually, and in Latvia, 56 million m3. The share of energy from agricultural biogas in Latvia is 1.6%, and in Poland, only 0.12%. This study analyzed the impact of the structure on CO2 emissions from agricultural biogas production in Latvia and Poland. The emission was determined in accordance with the EU directive. The structure of substrates was dominated by those from the second generation, i.e., manure and food waste. In Latvia, it was 70%, and in Poland, 78%. The manure share was 45% and 24%, respectively. The anaerobic digestion of manure guarantees high GHG savings thanks to the avoided emissions from the traditional storage and management of raw manure as organic fertilizer. The level of emissions from the production of agricultural biogas was calculated for the variant with the use of closed digestate tanks, and it was about 10–11 g CO2/MJ, which is comparable to the emissions from solar photovoltaic sources. When using open tanks, the emission level was twice as high, but it was still many times less than from the Polish or Latvian energy mix. Such a low level of emissions resulted from the high share of manure. The level of emission reduction reached 90% compared to fossil fuels. The use of second-generation feedstock in biogas production provides environmental benefits. Therefore, if wastes are used in biogas generation, and the influence on the local environment and overall GHG emissions is positive, authorities should support such activity.