bluuebunny/crossref_metadata_2025 huggingface dataset:
Grupo de hipertensos e diabéticos: Uma estratégia de educação para a saúde
Authors: Piasetzki Cláudia Thomé da Rosa , Boff Eva Teresinha de Oliveira , Corassa Danieli Maria
Published: October 2022

A hipertensão arterial sistêmica (HAS) e o diabetes mellitus (DM) são patologias prevalentes na população atendida pela Estratégia de Saúde da Família (ESF) do município de Bozano, localizado no interior do Estado do Rio Grande do Sul/Brasil. Conta com 2.160 usuários cadastrados, e 114 possuem o diagnóstico de DM e 502 de HAS. Considerando estes dados e a grande demanda para consultas com a nutricionista, criou-se o Grupo de Hipertensos e Diabéticos. Objetivo: Empoderar os usuários para que adquiram conhecimento sobre suas patologias e tornem-se conscientes de que a eficácia do tratamento depende de suas próprias ações de cuidado com a saúde. Metodologia: Pesquisa de campo, de caráter exploratório, com delineamento descritivo e transversal e abordagem quanti-qualitativa, realizada com um grupo de hipertensos e diabéticos do município de Bozano. Resultados: Foram realizados 8 encontros, somando-se 70 participantes. As idades variaram entre 35 e 82 anos, com média de 65,47 anos, sendo 52 (74,3%) idosos e 18 (25,7%) adultos, sendo 62,9% mulheres. Entre os participantes, 35,7% informaram ser hipertensos, 7,1% diabéticos, 21,4% hipertensos e diabéticos e 5,7% outros. A maioria dos participantes (65,7%) apresentou sobrepeso e risco elevado para doenças cardiovasculares (85,7%). Os participantes referiram ter aprendido sobre diabetes e hipertensão, ter se alimentado de forma mais saudável, tomaram mais água, fizeram exercícios e cuidaram da higiene do seu corpo e da sua boca. Conclusão: Os encontros tiveram impacto positivo, podendo ser considerados uma estratégia efetiva de educação alimentar e nutricional na situação de hipertensão e diabetes.
Exercício físico, sedentarismo e bem-estar dos/as estudantes universitários/as portugueses/as
Authors: Alves Regina Ferreira , Precioso José Alberto Gomes
Published: October 2022

A atividade física é considerada um comportamento de saúde positiva, sendo amplamente reconhecida a influência do exercício físico no bem-estar e qualidade de vida dos/as estudantes universitários/as. Os estilos de vida adquiridos durante o período acadêmico são passíveis de se manter ao longo da vida desse estudantes. O objetivo deste estudo foi explorar a relação entre a prática de exercício físico, o comportamento sedentário e o bem-estar de estudantes de uma universidade do norte de Portugal. Neste estudo, de carácter transversal, participaram 840 estudantes (55.4% pertencentes ao sexo feminino). A recolha de dados foi realizada por questionário validado e autoadministrado, composto pelo Godin Leisure-Time Exercise Questionnaire, para medir a prática de exercício físico, ao qual se acrescentou um item relativo ao comportamento sedentário, e pela Well-being Health Perception Scale (WbHPS) para medir o bem-estar. A prática de exercício físico, o bem-estar e a percepção de saúde encontram-se correlacionados, indicando que os/as estudantes sedentários/as revelaram um menor nível de bem-estar e percepção de saúde. Os itens que mais contribuem para os baixos escores da escala em universitários/as sedentários/as são a perceção de saúde e a satisfação com a forma física. Este estudo destaca a importância da prática de exercício físico na promoção do bem-estar dos/as estudantes, evidenciando que as instituições de Ensino Superior não se devem limitar ao desenvolvimento de competências profissionais, mas incluir estratégias que promovam o desenvolvimento holístico, incluindo a prática de exercício físico.
Atenção integral à pessoa idosa em unidade básica de saúde de um município do RS
Authors: Guidolin Vera Lúcia Quinhones , Venzant Esperanza Suárez , Da Silva Edi Branco , de Araújo Maria  Cristina Pansera , Boff Eva Teresinha de Oliveira
Published: October 2022

Os idosos apresentam um aumento da prevalência de doenças crônicas não transmissíveis e incapacidades que exigem políticas adequadas para uma vida saudável e de qualidade. O objetivo deste estudo foi elaborar uma proposta de intervenção na atenção à saúde dos idosos em um município do RS. O método quali-quantitativo do tipo estudo de caso analisou o programa em 12 semanas, com 269 usuários da área da Unidade Básica de Saúde (UBS). Constata-se a necessidade de atenção à saúde do idoso, inexistente na unidade. Os dados epidemiológicos foram coletados nas fichas cadastrais do Sistema de Informação em Atenção Básica das famílias. As ações consideraram quatro eixos: organização e gestão do serviço, monitoramento e avaliação, prática clínica e engajamento público. Este estudo resultou em novos cadastros, atenção aos idosos com o controle das doenças crônicas, atividades de intervenção e ações educativas em saúde no atendimento integral com envolvimento da população em ações intersetoriais. Nota-se que a Hipertensão Arterial Sistêmica (HAS), Diabetes Mellitus (DM) e Hipercolesterolemia constituíram causas mais frequentes de consulta. Muitos idosos, sem caderneta de saúde, foram atendidos como demanda espontânea. A avaliação multidimensional rápida e exames foram apropriados para 100% dos idosos acamados ou com problemas de locomoção. Ressalta-se que as intervenções melhoraram a execução das ações de saúde no cuidado a idosos em todos os cenários. O Ministério da Saúde preconiza ações específicas para a população idosa, porém com pouca promoção da saúde e prevenção de agravos. Um desafio permanente e contra hegemônico é assegurar acesso universal, constituinte e equânime ao Sistema Único de Saúde.
Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis
Authors: Oliveira Lucas , da Silva Ueveton , Braga João Pedro , Teixeira Álvaro , Ribon Andréa , Varejão Eduardo , Coelho Eduardo , de Freitas Camila , Teixeira Róbson , Moreira Renata
Published: October 2022

This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL–1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L. infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.
Pendampingan Usaha Kecil dan Menengah Sambal Puruluk Ma’ Erot Dalam Peningkatan Aspek Finansial
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Julyanti Julyanti , Kevin Ken ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Deuina E.Uren Michaela ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, M. Avivi Reyhan ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, R. Theno Ryan ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Suteja Valencia ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Juda Ida ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Kegiatan ini bertujuan untuk meningkatkan kondisi bisnis Sambal Puruluk Ma’ Erot dan bisnis lainnya yang dimiliki mitra dari segi keuangan. Pada awal kegiatan, keuangan merupakan salah satu masalah utama yang dihadapi oleh mitra jami karena sulitnya mengatur keuangan antar 1 bisnis dengan bisnis lainnya. Dari masalah ini, kelompok menyusun metode strategi peningkatan kondisi keuangan mitra berdasarkan melihat kekurangan dan kelebihan bisnis, memposisikan bisnis dalam matrik BCG, dan juga melihat kondisi keuangan setiap bulannya dari setiap bisnis yang dimiliki oleh mitra kami. Dari hasil yang ada, kelompok data merumuskan strategi perencanaan keuangan yang bisa digunakan oleh mitra sesuai dengan kondisi keuangannya. Harapannya, strategi yang diberikan dapat benar-benar membantu bisnis mitra untuk menjadi semakin baik dan berkembang di kemudian hari.
PENDAMPINGAN UMKM STICK YUMMY DI SUKATANI TERHADAP EFISIENSI PRODUKSI DAN PENJUALAN
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Soh Brigitta , Rusli Darren ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Wihardjo Joshua Evano ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Josia Michael ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Riani Stefany Elsha ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Suryajaya William Randy ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ariawan Eko ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Setiap tahun Universitas Prasetiya Mulya selalu menyelenggarakan Kegiatan Pengabdian Kepada Masyarakat (KPM), dengan tujuan pengembangan UMKM yang dimiliki oleh mitra agar menjadi mandiri. Ada banyak kesempatan dan ruang untuk perubahan ke arah yang lebih baik bagi mitra dari seluruh aspek proses bisnis. Manfaat dari program yang dilakukan tidak hanya tertuju pada bisnis mitra melainkan peningkatan pemahaman serta pengetahuan mitra akan strategi bisnis yang tepat. Dari hasil analisis situasi yang sempat dilakukan, kelompok melihat diperlukannya perubahan dari aspek operasional, aspek pemasaran, aspek keuangan, aspek penelitian dan pengembangan. Selama 30 hari, kelompok telah tinggal bersama mitra dan membantu usaha Stick Yummy untuk meningkatkan efisiensi produksi serta peningkatan penjualan yang terukur secara jelas. Penulisan dari artikel ini menggambarkan akan permasalahan yang dihadapi oleh usaha mitra, Stick Yummy, dan langkah-langkah yang dibentuk oleh kelompok demi menanggulangi permasalahan tersebut.
PENGEMBANGAN PROSES BISNIS PRODUK KARTINI: PRODUKSI SISTIK OLAHAN DARI DAUN KELOR
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Gunawan Veronica Thalia , Ericssen Ericssen ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Lorenzo Dinata Christopher ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Mai Deborah Eirene ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Tjondro Stanley Yosaphat ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Phangkajaya Varen ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Tamara Sesaria Kiki ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Kegiatan pengabdian kepada masyarakat (UKM) Universitas Prasetiya Mulya dilakukan dengan tujuan mengembangkan usaha milik mitra UMKM yang bekerjasama dengan Universitas Prasetiya Mulya. Melalui jurnal ini, salah satu usaha yang dikembangkan adalah “Produk Kartini” yaitu usaha UMKM yang menjual berbagai macam keripik dengan harga terjangkau dan terbuat dari berbagai macam bahan alternatif yang baik untuk kesehatan dan aman dikonsumsi oleh segala usia. Penulisan artikel ini bertujuan untuk menjabarkan dan memberikan gambaran mengenai pendampingan yang tim penulis telah lakukan baik dari segi operasional, pemasaran, keuangan, dan sumber daya sehingga didapatkan adanya peningkatan signifikan dalam keberhasilan usaha. Keberhasilan ini dapat terlihat dari meningkatnya produksi hingga 5-10 kg per bulan, telah adanya laporan laba rugi secara rutin serta pemisahan laporan keuangan usaha dengan pribadi oleh mitra, adanya logo dan fakta nutrisi dari kemasan sebgai salah satu teknik pemasaran, telah terjangkaunya 4 titik konsinyasi baru, varian produk baru, serta adanya pemasaran melalui sosial media produk untuk memperluas jangkauan konsumen.
URGENSI PARTISIPASI MASYARAKAT DALAM PROSES PENGEMBANGAN MASYARAKAT DI KOMUNITAS MISKIN PERKOTAAN
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Harisoesyanti Kania Saraswati , Annisah Annisah ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Kompleksitas masalah di perkotaan tidak cukup hanya diatasi secara sektoral, tetapi butuh kerjasama dari berbagai stakeholder; pemerintah, NGO, perguruan tinggi, dan masyarakat. Pengembangan masyarakat merupakan salah satu cara untuk mengatasi kompleksitas masalah ini. Kajian sebelumnya menunjukkan bahwa partisipasi menjadi faktor penentu keberhasilan program pengembangan masyarakat. Tulisan ini bertujuan untuk menjelaskan peran penting partisipasi masyarakat dalam proses pengembangan masyarakat di komunitas perkotaan. Penelitian ini dilakukan secara kualitatif dengan mengumpulkan data melalui wawancara mendalam, diskusi kelompok terfokus, dan observasi di Kampung Cikini-Ampiun, Kelurahan Pegangsaan, Jakarta Pusat. Hasil penelitian menunjukkan bahwa upaya pengembangan masyarakat yang dijalankan di wilayah ini bertujuan untuk mengatasi permasalahan keterbatasan ruang bermain bagi anak dengan memanfaatkan fasilitas umum yang tersedia yaitu Rumah Pintar. Namun demikian, upaya pengembangan masyarakat ini tidak dapat berjalan secara maksimal karena minimnya partisipasi masyarakat setempat. Kurangnya kesadaran akan manfaat dari Rumah Pintar dan konflik antar warga sebagai faktor utama minimnya partisipasi masyarakat. Oleh karena itu, penting dilakukan berbagai upaya pendekatan sebelum penerapan program pengembangan masyarakat agar masyarakat dapat berpartisipasi aktif dalam proses pengembangan masyarakat sehingga kebutuhan masyarakat dapat terpenuhi dan pengembangan masyarakat dapat berkelanjutan.
Consumer Culture Theory: Hubungan Timbal Balik antar Social Operant Resources dan Operand Resources dalam Studi Empiris McDonald’s Indonesia
Authors:   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Reksoprawiro Ricky , Scarlett Gabriella ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Ibnu Wibowo Alexander Joseph ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Amelia Novi ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta
Published: October 2022

Penelitian ini bertujuan untuk menguji secara empiris secara garis besar untuk mengetahui hubungan antara konsep social operant resources terhadap operand resources yang dilandasi oleh consumer culture theory. Secara spesifik, studi ini ingin menguji sebagai berikut: (i) pengaruh social operant resources terhadap economic operand resources; (ii) pengaruh social operant resources terhadap material operand resources; (iii) pengaruh economic operand resources terhadap social operant resources; dan (iv) pengaruh material operand resources terhadap social operant resources; (v) hubungan timbal balik antara social operant resources dan economic operand resources; (vi) hubungan timbal balik antara social operant resources dan material operand resources. Permasalahan dalam studi ini ditelaah dengan berbasis pada konsep consumer culture theory (CCT). Pengumpulan data primer dilakukan menggunakan kuesioner melalui survei online. Seluruh indikator diukur menggunakan skala Likert tujuh poin. Penelitian ini berhasil memperoleh data responden sebanyak 358 orang konsumen restoran McDonald’s. Teknik analisis faktor eksploratori exploratory factor analysis (EFA) diterapkan untuk melakukan uji validitas konstruk. Selanjutnya, keenam hipotesis diuji menggunakan teknik structural equation modeling (SEM). Hasil studi ini berhasil membuktikan bahwa keenam hipotesis yang diajukan tidak ditolak. Secara ringkas, social operant resources memengaruhi economic operand resources, social operant resources memengaruhi material operand resources, economic operand resources memengaruhi social operant resources, material operand resources memengaruhi social operant resources, ada hubungan timbal balik antara social operant resources dan economic material resources, dan ada hubungan timbal balik antara social operant resources dan material operand resources.
Analisis Hubungan Antara Karakteristik Iklan Online, Sikap Konsumen, Flow, dan Minat Membeli
Authors:   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Jessica Christie Maria , Pamuji Amelia Regina ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Widjojo Handyanto ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta, Murniadi Krishnamurti ,   Program Studi Branding, Universitas Prasetiya Mulya, Jakarta
Published: October 2022

Perkembangan Internet di Indonesia yang pesat mendorong munculnya perilaku masyarakat yang instan dan serba digital. Fenomena ini menyebabkan semakin maraknya media periklanan digital di Indonesia serta banyaknya iklan digital yang terpapar kepada konsumen. Penelitian ini bertujuan mengetahui hubungan antara karakteristik iklan (informativeness, entertainment, dan credibility), sikap konsumen dan minat membeli terhadap iklan online yang muncul pada platform Youtube, dan mengetahui faktor yang paling mempengaruhi minat membeli antara attitudes toward online advertising, subjective norm dan flow. Structural Equation Modelling digunakan sebagai metode pengolahan data. Penelitian ini melibatkan 181 responden pria dan wanita pengguna Youtube usia 19 - 34 tahun yang berdomisili di Jabodetabek dan belum pernah melihat iklan Coca-Cola Brotherly Love. Hasil penelitian menunjukkan bahwa entertainment, informativeness dan credibility mempengaruhi consumer attitude toward online advertising secara signifikan, demikian juga consumer attitude toward online advertising mempengaruhi purchase intention secara positif dan signifikan. Implikasi manajerial dari penelitian ini ialah untuk dapat meningkatkan purchase intention konsumen terhadap suatu produk melalui media iklan, maka penting untuk memastikan bahwa konsumen memiliki sikap yang positif terhadap iklan yang didapatkan melalui komponen karakter iklan online yaitu entertainment, informativeness dan credibility.
Pengaruh Sponsor-Event Congruence dalam kegiatan Sponsorship Festival Musik terhadap Attitude Toward The Brand, Brand Image dan Purchase Intention
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Wijaya Katarina O. , Soehadi Agus W. ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Sumarlin Antonius W. ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339
Published: October 2022

Kegiatan sponsorship, merupakan salah satu strategi pemasaran yang umum dilakukan oleh sebuah brand. Namun tidak banyak penelitian yang meneliti aktivitas sponsorship oleh brand sponsor dalam sebuah festival musik, yang dimana merupakan salah satu industri yang sangat berkembang dan diminati masyarakat Indonesia. Maka dari itu, penelitian ini difokuskan untuk memberikan kontribusi pada dunia riset, terutama dalam kategori kegiatan sponsorship dalam sebuah festival musik, dengan menganalisa pengaruh variabel Sponsor-event congruence, terhadap variabel Brand Image, Attitude towards the Brand, dan Purchase Intention. Peneliti telah mendapatkan 168 responden yang datang menikmati festival musik Java Jazz Festival 2019 dalam penyebaran kuesioner. Penelitian ini merupakan jenis penelitian kuantitatif, dengan penambahan in-depth interview terhadap 5 responden untuk membantu hubungan penelitian yang dianalisa. Data kuesioner didapatkan dengan menggunakan metode non-probaility sampling, yang dilanjutkan dengan purposive sampling, kemudian dianalisa menggunakan Structural Equation Modeling (SEM). Hasil menunjukan besarnya pengaruh keselarasan antara brand sponsor dengan festival musik yang disponsori, dan 4 dari 6 hipotesis yang dianalisa menunjukan adanya hubungan yang signifikan antara, Sponsor-Event Congruence terhadap variabel Brand Image, Attitude towards the Brand, dan Purchase Intention. Dengan arti bahwa, adanya dampak positif antara variabel Sponsor-Event Congruence terhadap Brand Image, dampak positif antara Sponsor-Event Congruence terhadap Attitude towards the Brand, dampak positif antara Sponsor-Event Congruence terhadap Purchase Intention, dan dampak positif antara Brand Image dengan Attitude towards the Brand.
The Sequestration of Bile Acids, A Non-Absorbed Method for Cholesterol Reduction. A Review
Authors: Mandeville W. Harry , Goldberg Dennis I.
Published: October 2022

Cholesterol lowcri11g therapies arc availahlc which act via several different mechanisms. The therapeutic classes currently available which afford these mechanisms arc diet, statins, fibrates, niacin, probucol and sequestrants. This review will focus on the various hilc acid scqucslranls, a class or lhcrapculics which has been under utilized due to patient compliance issues attributed lo the quantity or material required for effective treatment.
Regulation of Bile Acid Biosynthesis
Authors: Princen Hans M.G. , Post Sabine M. , Twisk Jaap
Published: October 2022

An elevated concentration of low density lipoprotein (LDL) cholesterol is an independent risk factor for cardiovascular disease. The only quantitatively significant way by which cholesterol is removed from the body is via the bile, either directly or after conversion to bile acids. Therapeutic modalities which increase bile acid biosynthesis,
e.g. bile acid-binding resins, have been shown to reduce plasma LDL levels and the risk of coronary heart disease. Their effects, however, are limited and patients' acceptibility is poor. This warrants the search for more potent drugs and new ways to enhance bile acid synthesis. In this review the various pathways along which bile acids are formed will be discussed with emphasis on the regulation of cholesterol 7o:-hydroxylase, the major rate­ limiting step in bile acid formation, as a target to increase bile acid synthesis. In the past
5 years our understanding of the transcriptional mechanism that regulates the expression of this gene has rapidly expanded. In view of the increasing evidence for the substantial contribution of the alternative or 27- hydroxylase route to bile acid synthesis, the current knowledge on sterol 27-hydroxylase, the first enzyme in this pathway and a potentially new target, is reviewed. Several companies are involved in developing new bile acid sequestrants and other inhibitors of intestinal bile acid absorption to remove cholesterol from the body. This review article presents recent developments in this field as appeared in the patent literature during past the years.
The 16-Ene Vitamin D Analogs
Authors: Uskokovic Milan R. , Studzinski George P. , Gardner Jeffrey P. , Reddy Satyanarayana G. , Campbell Moray J. , Koeffler H. Philip
Published: October 2022

Numerous 16-ene vitamin D analogs were investigated as potential anticancer agents. Several structural modifications have been uncovered that contribute to the improvement in the stimulation of HL-60 cells differentiation, the inhibition of HL-60 cells proliferation and the reduction of calcemic properties in vivo. They include the introduction of 16-, 22E-, 23E- and 23Z-double bonds, 23-triple bond or 22R-allene, and substitution of C26 and C27-hydrogens with fluorine or methyl groups. The biggest gains
have been achieved by combination of the 16-double bond with 23-double or triple bond and 26-trifluoro or 26,27-hexafluoro substitution patterns. Separately, the combination of the 16-double bond with 22R-allene has produced a highly active analog. In respect to modifications in the ring A, the high activities in cell differentiation and inhibition of cell proliferation with significant reduction of calcemic properties were observed in the lα-fluoro, 3-desoxy, and 19-nor series. It was also shown that the lack of the lα-hydroxy group can be overcome by an optimized modification in the ring D and the side chain; 25(OH)-16,23E-diene-26,27- F6D3 is fully active in HL-60 cell differentiation assay with only mimimal effects on the cellular calcium homeostasis.
Inhibitors of Influenza Virus Neuraminidase and Endonuclease
Authors: Sham Hing L. , Chen Xiaoqi
Published: October 2022

Influenza virus infection is considered to be one of the most common, yet serious respiratory infections in terms of morbidity and mortality. Currently available medications are limited. Amantadine and Rimantidine are only partially successful in treating. influenza A infection, and have no effect against influenza B viruses. Vaccination shows some success but meets with the difficulties of predicting the highly variable mutated strains in the forthcoming epidemic season. Recently, there has been extensive research efforts focuse on the areas of inhibitors of influenza virus
•neuraminidase and endonuclease. With detail understanding of the structural biology of influenza virus neuraminidase, Glaxo-Welcome's GG167 became the first potent neurami­
nidase inhibito which showed chemotherapeutic and chemoprophylactic effects in early human clinical trials. GGS4071, from Gilead Pharmaceutical, also demonstrated equivalent in vitro and invivo activities asGG I 67. GS4104, the ester pro-drug of GS4071 has good oral bioavailabilities in the animal assays. Along with the rapid developments in the area of neuraminidase inhibitors, cap-dependent endonuclease inhibitors which target the transcription of influenza virus mRNA are of great interest. The cap-dependent endonuclease seems to be unique to influenza virus with no cellular counterpart. The recent progress in the development of inhibitors of influenza neuraminidase and endonuclease are discussed in this review.
Inhibitors of Ergosterol Biosynthesis as Antifungal Agents
Authors: Hartman P.G. , Sanglard D.
Published: October 2022

The rise in the incidence of fungal infections over the past two to three decades, particularly those caused by opportunistic pathogens in immune-compromised patients, has strengthened the need for new antifungal drugs. Up to only 30 years ago the choice of systemically available antimycotics was between two drugs, amphotericin B and 5-flurocytosine, neither of which was satisfactory. Then a series of inhibitors of the biosynthesis of ergosterol, the major sterol of the fungal cell membrane, were found to
have excellent antifungal activity, improved safety, and some were also active after oral or parenteral application. Starting with miconazole and ketoconazole, and improving through fluconazole and itraconazole, the imidazole and triazole inhibitors of lanosterol Cl4u-demethylation have been the most successful. Other steps in the linear sterol biosynthesis pathway are inhibited by the allylamines naftifine and terbinafine, and the morpholine derivative amorolphine, which have also improved the therapy of superficial mycoses. The discovery, mode of action, current clinical application and future possibilities for these drugs is reviewed. The status and potential of SBI antifungals in development, exclusively azoles, is discussed. Attempts to discover non-azole inhbitors of lanosterol C14u-demethylase are mentioned, as well as current work on other targets in the ergosterol biosynthetic pathway. Particular attention is paid to the oxidsqualene cyclase, which has been extensively studied. The current knowledge about resistance to antifungal agents is reviewed.
Identification of EMT-associated LncRNA Signature for Predicting the
Prognosis of Patients with Endometrial Cancer
Authors: Shu Wan , Wang Ziwei , Zhang Wei , Zhang Jun , Zhao Rong , Yu Zhicheng , Dong Kejun , Wang Hongbo
Published: October 2022

Background:

Endometrial cancer (EC) is one of the most normal malignancies globally. Growing evidence suggests epithelial–mesenchymal transition (EMT) related markers are closely correlated with poor prognosis of EC. However, the relationship between multiple EMT-associated long non-coding RNAs (lncRNAs) and the prognosis of EC has not yet been studied.

Methods:

The transcriptome data and clinical information of EC cases were obtained from The Cancer Genome Atlas (TCGA), respectively. Then, we identified differentially expressed EMT-associated lncRNAs between tumor and normal tissue. Univariate cox regression analysis and multivariate stepwise Cox regression analysis was applied to identify EMT-associated lncRNAs that related to overall survival (OS). Kaplan-Meier curve, receiver operating characteristic (ROC), nomograms and multi-index ROC curves were further established to evaluate the performance of the prognostic signature. In addition, we also investigated the distribution of immune cell characteristics, sensitivity to immune checkpoint inhibitor (ICI) and chemotherapeutics, and tumor mutation burden (TMB) between high- and low-risk score predicated on a prognostic model.

Results:

We established nine EMT-associated lncRNA signature to predict the OS of EC, the area under the ROC curve (AUC) of the risk score has better values compared with other clinical characteristics, indicating the accuracy of the prognostic signature. As revealed by multivariate Cox regression, the prognosis model independently predicted EC prognosis. Moreover, the signature and the EMT-associated lncRNAs showed significant correlations with other clinical characteristics,including . Multi-index ROC curves for estimating 1-, 3- and 5-year overall survival (OS) of EC patients showed good predictive accuracy with AUCs of 0.731, 0.791, and 0.782, respectively. The high-risk group had specific tumor immune infiltration, insensitive to ICI, higher chemotherapeutics sensitivity and higher expression of TP53 mutation. Finally, the five lncRNAs of signature was further verified by qRT-PCR.

Conclusion:

We constructed an EMT-associated lncRNA signature that can predict the prognosis of EC effectively, and the prognostic signature also played an essential role in the TME; thus, the establishment of EMT-associated lncRNA signature may provide new perspectives for the treatment of EC.
Gut Microbiota and Colorectal Cancer Risk Factors
Authors: Feizi Hadi , Rezaee Mohammad Ahangarzadeh , Ghotaslou Reza , Sadrkabir Mohammad , Jadidi-Niaragh Farhad , Gholizadeh Pourya , Taghizadeh Sepehr , Ghanbarov Khudaverdi , Yousefi Mehdi , Kafil Hossein Samadi
Published: October 2022

Colorectal cancer is a type of gut cancer originating either from the rectum or colon. Genetic
and environmental factors, such as the gut microbiome, play pivotal roles in colorectal cancer
incidence rates. Therefore, we aimed to review the risk factors of CRC comprising gut bacteriomes
and their intra-interactions with each other in the context of CRC development. Gut microbiota alteration,
especially bacteriome alteration as the dominant player, seems to be the common feature
amongst all risk factors. Although it is not quite obvious whether these alterations are the causes or
the consequences of the tumorigenesis risk factors, they are common and almost universal among
CRC-affected individuals. In addition, bacterial genotoxicity, biofilm formation, oxidative stress,
bacterial metabolome, and dysbiosis are assessed in CRC development. The present study suggests
that gut microbial alterations could be the key intermediate, as a cause or a consequence, between
most risk factors of CRC and the way they promote or contribute to CRC development.
COVID-19 and Thrombosis: Clinical Aspects
Authors: Urano Tetsumei , Yasumoto Atsushi , Yokoyama Kenji , Horiuchi Hisanori , Morishita Eriko , Suzuki Yuko
Published: October 2022

In coronavirus disease 2019 (COVID-19), thrombus formation is related to the pathogen-esis of acute respiratory distress syndrome (ARDS) and the progression of clinical symptoms. Se-vere damage to vascular endothelial cells and the associated cytokine storm after SARS-CoV-2 in-fection cause thrombogenesis and contribute to the development of more severe and unique throm-boses compared to other infectious diseases. Thromboses occur more often in critically ill patients. In addition to pulmonary thromboembolism (PE) and deep vein thrombosis, acute myocardial in-farction, peripheral arterial thrombosis, and aortic thrombosis have also been reported. In PE, thrombi develop in both pulmonary arteries and alveolar capillaries. These, together with intra-alveolar fibrin deposition, interfere with effective gaseous exchange in the lungs and exacerbate the clinical symptoms of ARDS in patients with COVID-19. Pharmacological thromboprophylaxis is recommended for all hospitalized patients to prevent both thrombosis and aggravation of ARDS, and other organ failures. Although the pediatric population is mostly asymptomatic or develops mild disease after SARS-CoV-2 infection, a new inflammatory disorder affecting the cardiovascular system, multisystem inflammatory syndrome in children (MIS-C), has been reported. Similar to Kawasaki disease, acute myocarditis, coronary vasculitis, and aneurysms are typically seen in MIS-C, although these two are now considered distinct entities. A similar acute myocarditis is also ob-served in young male adults, in which a hyperinflammatory state after SARS-CoV-2 infection seems to be involved. Several side effects following vaccination against COVID-19 have been re-ported, including vaccine-induced immune thrombotic thrombocytopenia and acute myocarditis. Although these could be serious and life-threatening, the cases are very rare, thus, the benefits of immunization still outweigh the risks.
Prediction of Rhizoma Drynariae Targets in the Treatment of Osteonecrosis
of the Femoral Head based on Network Pharmacology and Experimental
Verification
Authors: Zhang Yong , Weng Qiuyan , Hu Tongzhou , Shen Xiaohan , Han Jinming
Published: October 2022

Background:

Rhizoma drynariae, a classic prescription in traditional Chinese medicine, has
long been used for the treatment of osteonecrosis of the femoral head (ONFH), but its potential targets
and molecular mechanisms remain to be further explored.

Objective:

This study aims to explore the mechanism of Rhizoma drynariae in ONFH treatment via
network pharmacology and in vitro experiments.

Methods:

Targets of Rhizoma drynariae and ONFH were predicted using relevant databases, and intersection
analysis was conducted to screen for shared targets. A PPI network of the shared targets was
built using STRING to identify the key targets. Functional enrichment analyses of Gene Ontology and
KEGG pathway data were carried out using R software. The compound-target-pathway network was
constructed for Rhizoma Drynariae in the treatment with ONFH using Cytoscape 3.9.0. Cell proliferation
was assessed using CCK8 and apoptosis was detected using (Propidium Iodide) PI staining and
western blotting.

Results:

This study depicts the interrelationship of the bioactive compounds of Rhizoma drynariae with
ONFH-associated signaling pathways and target receptors and is a potential reagent for ONFH treatment.

Conclusion:

Based on a network pharmacology analysis and in vitro experiment, we predicted and validated
the active compounds and potential targets of Rhizoma drynariae, provide valuable evidence of
Rhizoma Drynariae in future ONFH treatment.
Internet of Things- Implementation in Healthcare with Telemedicine &
Robotic
Authors: Mishra Sudhanshu
Published: October 2022

Smart healthcare is a healthcare delivery method that utilizes wearable devices, the internet
of things, and the mobile internet to dynamically access information, connect people, materials, and
institutions in the healthcare industry, and then intelligently monitor and respond to the medical ecosystem
requirements. The concept of smart healthcare has progressively gained traction as information
technology advances like Telemedicine and Robotics. The purpose of the internet of things (IoT) is to
connect many effects and items present in the surroundings so they may communicate and work together
"anytime, anywhere, with anything and anyone, flawlessly using any path or network and any
service."Smart healthcare employs a new generation of information technologies, such as the IoT, big
data, cloud computing, and artificial intelligence, to completely revolutionize the existing medical system,
making it more efficient, easy, and personalized. Thereby, to introduce the concept of “smart
healthcare”, foremost, we identify the essential technologies that support it and discuss the current
state of smart healthcare in a few key areas.
Nigella sativa, a Jack of All Trades Plant in Medicine: Pharmacological
Aspects in Diseases Treatment and Prevention
Authors: Akhzari Morteza , Mohammadi Shiva , Jalili Sajad , Barazesh Mahdi , Noorizadeh Karim
Published: October 2022

Nigella sativa L. (Ranunculaceae) is one of the most widely used traditional therapeutic
plants. It possesses important classes of bioactive compounds, among which thymoquinone, as the
major bioactive component of the essential oil, has attracted noteworthy attention due to its active role
in treating various disorders. N. sativa can induce a wide range of pharmacological functions, including
anti-oxidative stress responses, antidiabetic, anticancer, cell apoptosis, increased membrane permeability,
immunomodulatory, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilatory,
hepato-protective, renal protective, gastro-protective, and antioxidant properties. The seeds of N.
sativa, commonly known as black seed or black cumin, show many potential pharmacological roles
and are utilized in folk (herbal) medicine all over the world for the treatment and prevention of a various
range of diseases and conditions, including asthma, cancers, inflammatory situations, type 2 diabetes
mellitus disorders, bacterial and viral infections, and dyslipidemia. This review outlines the main
pharmacological properties of N. sativa and its components due to their potential wide applications for
a large variety of human diseases. The seeds constitute fixed and essential oils, proteins, alkaloids and
saponin. Much of the biological function of the seeds has been demonstrated to be due to thymoquinone.
Beneficial influences of the seeds application and thymoquinone might be contributed to their
cytoprotective and antioxidant functions and their effect on immune response and some inflammatory
mediators.
Distinct MicroRNAs Identified in Rabbit Blood Arising from Induced
Diabetes and a Surgically Simulated Diabetic Ischemia Complication
Authors: Kotwal Girish J. , Waigel Sabine , Chariker Julia , Rouchka Eric , Chien Sufan
Published: October 2022

Background:

Diabetic complications have been studied extensively in recent years.
There are very few biomarkers in body fluids that can pinpoint a distinct diabetic complication due
to insufficient known specific biomarkers for ischemia.

Objective:

Identifying microRNA in animal models for each complication could enable early diagnosis
of a given complication if verified in humans. MicroRNA (miRNA) profiling has been done
in rodent models for a number of diabetic complications, like diabetic glomerular injury, atherosclerosis,
cognitive impairment, diabetic wound healing, angiopathy and other complications. Due to
multiple differences between rodents and humans, the changes in rabbit skin, considered closer to
humans than even pigs, may better simulate human diabetic complications of ischemia.

Methods:

To study the miRNA profile of rabbits in which diabetes was induced or ischemia was
surgically generated, we studied whether diabetes or ischemia-induced specific miRNA could be
detected. MicroRNA from the blood of diabetic rabbits and rabbits with local ischemia was collected
in PAXgene Blood RNA tubes specifically designed for miRNA isolation and extracted using the
PAX gene miRNA extraction kit. The isolated RNA was quality controlled using an RNA analyzer,
and further, using RNA seq technology, it was analyzed for distinct miRNAs that were detected in
diabetic and non-diabetic rabbits induced with ischemia.

Results:

A miRNA that was found to be expressed in diabetic rabbits and ischemic rabbits but not
in untreated rabbits was miRNA-183. Several miRNAs were differentially expressed across comparison
groups, and several upregulated miRNAs were identified being unique to each comparison.
In rabbits with a potential diabetic complication of a long-term ischemic model, there was one distinct
microRNA, which was highly significantly upregulated in ischemia rabbit (miRNA-133-3p).
One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits
was miRNA-3074-5p. Only statistically significant results have been considered and analyzed.

Conclusion:

These findings could lead to a precise and timely diagnosis of a potential single diabetic
complication without invasive tissue biopsies and could be a novel tool in the management of diabetic
patients developing complications due to the progression of diabetes.
An Insight View on the Role of Herbal Medicines in Infectious Diseases
Authors: Gautam Rupesh K. , Parashar Smriti , Goyal Rajat , Sharma Sanjay , Gupta Sumeet , Mittal Pooja
Published: October 2022

Nature always has enough spirit and resilience to transform our limited vision. Herbal medicines include products prepared from natural herbs which are employed to treat several diseases. In India, about 80% of drugs are of herbal origin. Nowadays, people are much more aware of the various side effects of synthetic drugs, which have molded their interest in herbal products and herbal remedies. In history, various infectious diseases or pandemic conditions have been treated or controlled with herbal medicines. Many herbal plants like Emblica officinalis (Euphorbiaceae), Withania somnifera (Solanaceae), Swertia chirata (Gentianaceae), Asparagus racemosus (Liliaceae), and Vinca rosea/Catharanthus roseus (Apocynaceae) have been reported to be of high medicinal values and preferred in the development of many newer drugs. The active component from plant extract is isolated, standardized, and undergoes safety trials for validation. Novel drug development from herbs is the amalgamation of practices of native systems of medicine and quite a lot of therapeutic experience of earlier generations. It is also believed that most herbal contents are safe, cheap, and easily available. Herbal drugs are useful in various diseased and pathogenic conditions like tuberculosis, cancer, diabetes, AIDS, jaundice, skin diseases, etc. Many countries with ancient cultures like India, Egypt, and America still use various herbal-based medications. Research for future herbal product development is increasing worldwide. Therefore, taking into consideration future perceptions of herbal remedies, this review deals with the present status and future exploration in the development of herbal drugs as modern beneficial agents for treating various infectious diseases and related pharmacological problems.
Cooperative Spectrum Sensing in Cognitive Radio Networks: A Systematic Review
Authors: Jain Sharad , Yadav Ashwani Kumar , Kumar Raj , Yadav Vaishali
Published: October 2022

Background:

Spectrum is the backbone for wireless communications including internet services. Now days, the business of industries providing wired communication is constant while the business of industries dealing with wireless communications is growing very fast. There is large demand of radio spectrum for new wireless multimedia services. Although the present fixed spectrum allotment schemes do not cause any interference between users, but this fixed scheme of spectrum allocation do not allow accommodating the spectrum required for new wireless services. Cognitive radio (CR) relies on spectrum sensing to discover available frequency bands so that the spectrum can be used to its full potential, thus avoiding interference to the primary users (PU).

Objectives:

The purpose of this work is to present an in-depth overview of traditional as well as advanced artificial intelligence and machine learning based cooperative spectrum sensing (CSS) in cognitive radio networks.

Method:

Using the principles of artificial intelligence (AI), systems are able to solve issues by mimicking the function of human brains. Moreover, since its inception, machine learning has demonstrated that it is capable of solving a wide range of computational issues. Recent advancements in artificial intelligence techniques and machine learning (ML) have made it an emergent technology in spectrum sensing.

Result:

The result shows that more than 80% papers are on traditional spectrum sensing while less than 20% deals with artificial intelligence and machine learning approaches. More than 75% papers address the limitation of local spectrum sensing. The study presents the various methods implemented in the spectrum sensing along with merits and challenges.

Conclusion:

Spectrum sensing techniques are hampered by a variety of issues, including fading, shadowing, and receiver unpredictability. Challenges, benefits, drawbacks, and scope of cooperative sensing are examined and summarized. With this survey article, academics may clearly know the numerous conventional artificial intelligence and machine learning methodologies used and can connect sharp audiences to contemporary research done in cognitive radio networks, which is now underway.