bluuebunny/crossref_metadata_2025 huggingface dataset:
Laser Texturing for Superwetting Titanium Alloy and Investigation of Its Erosion Resistance
Authors: Wang Zhiguo , Song Jinpeng , Wang Tianyi , Wang Huixin , Wang Qinghua
Published: December 2021

Erosion of materials is one of the major causes that lead to the malfunction of equipment and facilities, and surface texturing can be a solution for enhancement of erosion resistance. In this work, superwetting (superhydrophilic/superhydrophobic) titanium (Ti) alloy surface with periodic microstructure was prepared by a facile laser-based surface texturing approach which combines laser surface texturing and low-temperature annealing. The effect of laser-induced surface texture and wettability on the erosion resistance of the laser textured surface was studied. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) were used to analyze the chemical surface microstructure and surface on the untreated and laser textured surfaces. The hardness and contact angle of the untreated surface, superhydrophilic surface and superhydrophobic surface were measured by microhardness tester and contact angle goniometer. Using an in-house built erosion experimental setup, the erosion resistance of the untreated surface, superhydrophilic surface and superhydrophobic surface was investigated. The experimental results demonstrate that micro-bumps are formed after laser surface texturing. In the meantime, the surface hardness for the laser textured surface with a step size of 150 μm is increased by 48% under the load of 1.961 N. Compared with the untreated surface, the erosion resistance is increased by 33.9%, 23.8% and 16.1%, respectively, for the superhydrophobic surface. The SEM results show that the untreated surface has large and deep impact pits, while the superhydrophobic surface only has small and shallow impact pits, indicating that the erosion process resulted in less damage to the substrate. The EDS results shows that superhydrophobicity plays a critical role in protecting the substrate from erosion. It is thus believed that the superhydrophobic surface has pronounced effects for improving the hardness and erosion resistance of Ti alloy.
Fabrication of a High Water Flux Conductive MWCNTs/PVC Composite Membrane with Effective Electrically Enhanced Antifouling Behavior
Authors: Chen Xi , Gao Jiabin , Song Yunchang , Gong Yaping , Qi Meng , Hao Runlong
Published: December 2021

Membrane fouling is a major issue that deteriorates the performance of membrane filtration systems. The electrically assisted membrane filtration process is proven to be effective for alleviating membrane fouling. In this study, we synthesized an electrically conductive membrane by incorporating multiwalled carbon nanotubes (MWCNTs) into polyvinyl chloride (PVC). The synthesized membranes have larger porosity than the PVC membrane (incorporating polyethylene glycol (PEG)), and thus possess much higher water flux under the same testing conditions. The initial and stable water fluxes are 2033 L/(m2·h) and 750 L/(m2·h), respectively, which are much higher than that of the pure PVC membrane. More importantly, the membrane has higher surface charge density and excellent electrical conductivity, but the surface hydrophilicity and toughness decreased with the addition of the MWCNTs. The 25 wt % MWCNTs/PVC composite membrane possesses suitable electrical conductivity of 0.128 S/m. The same membrane shows electro-enhanced antifouling performance during the antifouling test with yeast as a model foulant because the external electric field (−2 V) impulses a strong repulsion force while producing some micro bubbles to repel the foulant; thus, the membrane fouling is suppressed. In the current study, we develop a simple method to fabricate the electrically conductive membrane for application in the electrically assisted membrane filtration process.
Effect of Nutrient Solution Composition on Bio-Cemented Sand
Authors: Liang Shihua , Xiao Xueli , Li Zhanlin , Feng Deluan
Published: December 2021

Microbial-induced carbonate precipitation is an environmentally friendly foundation treatment technology that effectively improves soil engineering performance. The various nutrient components of liquid curing compounds significantly influence the curing effect. On the basis of penetration, dry density, water absorption, and unconfined compressive strength tests, this study showed the effect of nutrient solution composition, including urea, calcium chloride, sodium bicarbonate, ammonium chloride, and nutrient broth, on the physicomechanical properties of bio-cemented sand. The morphological differences of calcium carbonate precipitates under nutrient solution composition were compared through scanning electron microscopy (SEM). Results showed that the curing effect of compound nutrient solution was improved compared with the basic nutrient solution (urea and calcium chloride). Among the individual components added, ammonium chloride had the most remarkable effect, followed by sodium bicarbonate and nutrient broth. Among the paired components added, sodium bicarbonate + ammonium chloride had the most significant effect, followed by sodium bicarbonate + nutrient broth and ammonium chloride + nutrient broth. The strength of bio-cemented sand cured with compound nutrient solution containing five components could reach 3.43 MPa, which was 1.92 times higher than the strength of the basic nutrient solution. As shown by the SEM image, the calcium carbonate precipitation in the solidified sand was distributed in the clearance of sand particles, effectively bonding the sand particles. The calcium carbonate obtained by the composition of the compound nutrient solution precipitated the sand particles, and some of the sand particles were wrapped. Moreover, the amount of precipitation was evidently greater than that of the basic nutrient solution. Compared with the basic nutrient solution, the compound nutrient solution effectively reduced the apparent porosity and average pore size of the sand. Thus, the curing effect of the compound nutrient solution was better than that of the basic nutrient solution.
Appendicularia (Tunicata) in an Antarctic Glacial Fjord–Chaotic Fjordic Structure Community or Good Indicators of Oceanic Water Masses?
Authors: Panasiuk Anna , Kalarus Marcin
Published: December 2021

Appendicularians are important but remain poorly studied groups of zooplankton in polar regions. The present research is based on samples collected in Admiralty Bay (King George Island) during a year-long period. Six larvacean species were noted, among which Fritillaria borealis and Oikopleura gaussica were found to be the most numerous, while the other species were relatively rare. Fritillaria borealis was a dominant part of the late summer (warm water) community, while O. gaussica had the highest presence in the winter (cold water) community. The abundance of appendicularians recorded in the bay was less numerous than that described by other authors. The most important factors influencing annual changes in the larvaceans in the bay was season, but only in the case of the two species. These facts were probably linked to the very dynamic changes in the abiotic conditions in the fjord, and the influx of specific masses of water.
Pathways to Unsegregated Sharing of Airspace: Views of the Uncrewed Aerial Vehicle (UAV) Industry
Authors: Grote Matt , Pilko Aliaksei , Scanlan James , Cherrett Tom , Dickinson Janet , Smith Angela , Oakey Andy , Marsden Greg
Published: December 2021

The uncrewed aerial vehicle (UAV or drone) industry is expanding, offering services such as video/photography, inspection, monitoring, surveying, and logistics. This is leading to competing demands for airspace with existing crewed aircraft activities, especially in uncontrolled airspace. As a result, there is an increasingly urgent need for a shared airspace solution that enables drones to be integrated with the wider aviation community in unsegregated operations. The purpose of this research was to engage with the drone industry to understand their issues regarding shared airspace as an important first step in the co-development of operating procedures that can provide equitable airspace access for all. An online, interactive workshop format was employed, with participants (n ~ 80) drawn from the UK drone industry and other attendant organisations. Verbal and written data were recorded, and then analysed using thematic analysis. The findings summarise the issues on a range of topics, grouped into three over-arching themes: (1) operational environment; (2) technical and regulatory environment; and (3) equity and wider society. Results suggested that important issues included the necessity for a dependable detect-and-avoid (DAA) system for in-flight de-confliction, based on onboard electronic conspicuity (EC) devices, and the need for support for shared airspace from the wider aviation community. This study contributes to the stakeholder engagement that will be essential if the co-development of a shared airspace solution is to be widely acceptable to all.
Multi-Level Fusion Temporal–Spatial Co-Attention for Video-Based Person Re-Identification
Authors: Pei Shengyu , Fan Xiaoping
Published: December 2021

A convolutional neural network can easily fall into local minima for insufficient data, and the needed training is unstable. Many current methods are used to solve these problems by adding pedestrian attributes, pedestrian postures, and other auxiliary information, but they require additional collection, which is time-consuming and laborious. Every video sequence frame has a different degree of similarity. In this paper, multi-level fusion temporal–spatial co-attention is adopted to improve person re-identification (reID). For a small dataset, the improved network can better prevent over-fitting and reduce the dataset limit. Specifically, the concept of knowledge evolution is introduced into video-based person re-identification to improve the backbone residual neural network (ResNet). The global branch, local branch, and attention branch are used in parallel for feature extraction. Three high-level features are embedded in the metric learning network to improve the network’s generalization ability and the accuracy of video-based person re-identification. Simulation experiments are implemented on small datasets PRID2011 and iLIDS-VID, and the improved network can better prevent over-fitting. Experiments are also implemented on MARS and DukeMTMC-VideoReID, and the proposed method can be used to extract more feature information and improve the network’s generalization ability. The results show that our method achieves better performance. The model achieves 90.15% Rank1 and 81.91% mAP on MARS.
A Smooth Path between the Classical Realm and the Quantum Realm
Authors: Klauder John R.
Published: December 2021

A simple example of classical physics may be defined as classical variables, p and q, and quantum physics may be defined as quantum operators, P and Q. The classical world of p&q, as it is currently understood, is truly disconnected from the quantum world, as it is currently understood. The process of quantization, for which there are several procedures, aims to promote a classical issue into a related quantum issue. In order to retain their physical connection, it becomes critical as to how to promote specific classical variables to associated specific quantum variables. This paper, which also serves as a review paper, leads the reader toward specific, but natural, procedures that promise to ensure that the classical and quantum choices are guaranteed a proper physical connection. Moreover, parallel procedures for fields, and even gravity, that connect classical and quantum physical regimes, will be introduced.
CSR in Management Sciences: Is It “a Road to Nowhere”?
Authors: Janowski Andrzej
Published: December 2021

Over the years, the idea of corporate social responsibility has attracted the interest both of practitioners and researchers. While a discourse has occurred in the context of the meaning of Corporate Social Responsibility (CSR), there is no extensive analysis of the latest contributions. To address this gap, three objectives have been formulated for the purpose of this paper: to analyse development trends in CSR definitions, to assess the applicability of scientific efforts in the above-mentioned area and to demonstrate future research opportunities and threats based on the state-of-the-art in CSR. An organized literature review and bibliometric methods have been proposed based on 55 articles published in the “Corporate Social Responsibility and Environmental Management Journal”, the top ranked periodical with the highest Impact Factor, from its beginnings to January 2021. This research provides a clear overview of the recent CSR trends that are present in the literature, by pinpointing those works that refer to significant characteristics and indicate future trajectories of CSR in a managerial practical context, particularly important for the effectiveness of future CSR-oriented organizational activities. This paper summarises the existing CSR-related knowledge and constitutes the first attempt to investigate the process of the creation and development of the corporate social responsibility concept from its origins to its contemporary multidimensionality.
Hazards Generated by an LNG Road Tanker Leak: Field Investigation of Vapour Propagation under Class B Conditions of Atmospheric Stability
Authors: Węsierski Tomasz , Piec Robert , Majder-Łopatka Małgorzata , Król Bernard , Gawroński Wiktor , Kwiatkowski Marek
Published: December 2021

The publication presents the results of a field test of 2–4 min releases of 96% LNG from a road tanker designed to carry the gas. The release was performed at a pressure of 5.9–6.1 atm at a discharge rate of 1.67–1.78 kg/s from a height of 0.75 m under class B conditions of atmospheric stability. Comparison of the obtained experimental results of the maximum concentrations and the simulation carried out with the EFFECS (11.2.0) software showed that the Gaussian gas model better describes the gas cloud propagation at most control points at this release intensity than the dense gas model. The dense gas model gave only slightly better results along the cloud propagation axis at close distances, not exceeding 25/30 m at ground level. It is shown that concentrations between 71% and 110% LEL are observed at the cloud visibility limit. The maximum value of the temperature drop, in the release axis, at a distance of 4 m amounts to ∆Tmax = 93.3 °C. This indicates that the cloud of the released LNG is almost entirely in the vapour state already in the short distance from the point of release, due to the turbulent outflow of the pressurised gas.
The Concept of Entropy and Its Application in Thermal Engineering
Authors: Haseli Yousef
Published: December 2021

Today, 156 years after the invention of entropy by Clausius, there remains disagreement among the scientific community on what entropy and the phenomenon of entropy increase mean [...]
Generic Upscaling Methodology of a Floating Offshore Wind Turbine
Authors: Wu Jeffrey , Kim Moo-Hyun
Published: December 2021

This study presents a generic method to upscale a semi-submersible substructure and tower-nacelle-blade for a floating offshore wind turbine from 5 MW to 15 MW and beyond. The effects of upscaling the column radius and/or distance of the floating base are investigated, and a comparison is made with a 15 MW reference design. It is found that scaling column radius increases the mass of the platform and the heave natural period, while scaling column distance raises the center of gravity and metacentric height of the floating system and slightly decreases the heave natural period. The 15 MW reference design addresses these issues through design changes that increase the ballast mass to lower the center of gravity, and increase the added mass to raise the heave natural period. Finally, a method for estimating the scaling of platform parameters with different assumptions is proposed.
Prospects for Solar Energy Development in Belarus and Tatarstan
Authors: Bahach Uladzimir , Brin Anton , Vankov Yuri , Verchak Konstantin , Afanaseva Olga , Ilyashenko Svetlana
Published: December 2021

This paper discusses the resource, technical, and economic potential of using solar photovoltaic (PV) systems in Belarus and Tatarstan. The considered countries are characterized by poor actinometric conditions and relatively low tariffs for traditional energy resources. At the same time, Belarus is experienced with solar power due to different incentive mechanisms that have been used over the past decade. Moreover, the cost of building solar power plants in Belarus in 2013–2017 was lower than the world average. The cost of electricity production is analyzed depending on the geographical location of sites and the type of owners of solar power plants (i.e., households, businesses and industrial enterprises, electricity producers). Using the data on the cost of photovoltaic systems as presented by IRENA and considering actinometric data for Belarus and Tatarstan, a long-term forecast of PV electricity cost is made. The moments of the break-even points and payback periods are defined for Belarus and Tatarstan.
Analysis of the Influence of Coal Petrography on the Proper Application of the Unipore and Bidisperse Models of Methane Diffusion
Authors: Karbownik Marcin , Krawczyk Jerzy , Godyń Katarzyna , Schlieter Tomasz , Ščučka Jiří
Published: December 2021

The analysis of phenomena related to gas transport in hard coal is important with regard to the energetic use of coal bed methane (CBM), the reduction of greenhouse gas emissions to the atmosphere (CO2) and the prevention of natural hazards such as methane hazards and gas and rock outbursts. This article presents issues concerning the feasibility and scope of applying the unipore and bidisperse diffusion models to obtain knowledge concerning the kinetics of methane sorption and its diffusion in the carbon structure, depending on its petrography. Laboratory tests were carried out on coal samples which varied in terms of petrography. Quantitative point analyses were carried out, based on which content of groups of macerals was determined. The degree of coalification of coal samples was also determined based on measurements of vitrinite reflectivity R0 and the volatile matter content Vdaf. Sorption kinetics were also investigated, and attempts were made to adjust the unipore and bidisperse models to the real sorption kinetic courses. This allowed the identification of appropriate coefficients controlling the course of sorption in mathematical models. An attempt was also made to assess the possibility of applying a given model to properly describe the phenomenon of methane sorption on hard coal.
Linearized Frequency-Dependent Reflection Coefficient and Attenuated Anisotropic Characteristics of Q-VTI Model
Authors: Yang Yahua , Yin Xingyao , Zhang Bo , Cao Danping , Gao Gang
Published: December 2021

Seismic wave exhibits the characteristics of anisotropy and attenuation while propagating through the fluid-bearing fractured or layered reservoirs, such as fractured carbonate and shale bearing oil or gas. We derive a linearized reflection coefficient that simultaneously considers the effects of anisotropy and attenuation caused by fractures and fluids. Focusing on the low attenuated transversely isotropic medium with a vertical symmetry axis (Q-VTI) medium, we first express the complex stiffness tensors based on the perturbation theory and the linear constant Q model at an arbitrary reference frequency, and then we derive the linearized approximate reflection coefficient of P to P wave. It decouples the P- and S-wave inverse quality factors, and Thomsen-style attenuation-anisotropic parameters from complex P- and S-wave velocity and complex Thomsen anisotropic parameters. By evaluating the reflection coefficients around the solution point of the interface of two models, we analyze the characteristics of reflection coefficient vary with the incident angle and frequency and the effects of different Thomsen anisotropic parameters and attenuation factors. Moreover, we realize the simultaneous inversion of all parameters in the equation using an actual well log as a model. We conclude that the derived reflection coefficient may provide a theoretical tool for the seismic wave forward modeling, and again it can be implemented to predict the reservoir properties of fractures and fluids based on diverse inversion methods of seismic data.
Microplastic Contamination in Human Stools, Foods, and Drinking Water Associated with Indonesian Coastal Population
Authors: Luqman Arif , Nugrahapraja Husna , Wahyuono Ruri Agung , Islami Izzatul , Haekal Muhammad Husain , Fardiansyah Yasri , Putri Balqis Qonita , Amalludin Fahmi Ikhlasul , Rofiqa Elsalisa Ainur , Götz Friedrich , Wibowo Anjar Tri
Published: December 2021

Approximately 381 million tons of plastic are produced globally every year, and the majority of it ends up as pollutants. In the environment, plastic waste is fragmented into microplastic particles less than 5 mm in size; owing to their small size, durability, and abundance, they can easily be dispersed, incorporated into the food chains, and enter the human body. The extent of microplastic exposure in the human body has become a major concern in many countries, including in Indonesia, the second largest plastic waste contributor in the world. Here, we report the detection of microplastics in human stools collected from a fisherman community in the coastal area of Surabaya, Indonesia. Microplastics were found in more than 50% of samples analyzed with a concentration ranging from 3.33 to 13.99 µg of microplastic per gram of feces (µg/g). HDPE was observed as the most prevalent type of microplastic, with an average concentration of 9.195 µg/g in positive samples. Different types of microplastics were also detected in seafood, staple foods, drinking water, table salts, and toothpaste, which were regularly used and consumed by the study participants. Results from this preliminary study indicate widespread contamination of microplastic in the human body and in consumables associated with the coastal populations of Indonesia.
Strategic Application of Topoclimatic Niche Models in Managing Forest Change
Authors: Worrall James J. , Rehfeldt Gerald E.
Published: December 2021

Forest management traditionally has been based on the expectation of a steady climate. In the face of a changing climate, management requires projections of changes in the distribution of the climatic niche of the major species and strategies for applying the projections. We prepared climatic habitat models incorporating heatload as a topographic predictor for the 14 upland tree species of southwestern Colorado, USA, an area that has already seen substantial climate impacts. Models were trained with over 800,000 points of known presence and absence. Using 11 climate scenarios for the decade around 2060, we classified and mapped change for each species. Projected impacts are extensive. Except for the low-elevation woodland species, persistent habitat is rare. Most habitat is lost or threatened and is poorly compensated by emergent habitat. Three species may be locally extirpated. Nevertheless, strategies are described that can use the projections to apply management where it is likely to be most effective, to facilitate or assist migration, to favor species likely to be suited in the future, and to identify potential climate refugia.
Potentials of Endophytic Fungi in the Biosynthesis of Versatile Secondary Metabolites and Enzymes
Authors: Slama Houda Ben , Chenari Bouket Ali , Alenezi Faizah N. , Pourhassan Zeinab , Golińska Patrycja , Oszako Tomasz , Belbahri Lassaad
Published: December 2021

World population growth and modernization have engendered multiple environmental problems: the propagation of humans and crop diseases and the development of multi-drug-resistant fungi, bacteria and viruses. Thus, a considerable shift towards eco-friendly products has been seen in medicine, pharmacy, agriculture and several other vital sectors. Nowadays, studies on endophytic fungi and their biotechnological potentials are in high demand due to their substantial, cost-effective and eco-friendly contributions in the discovery of an array of secondary metabolites. For this review, we provide a brief overview of plant–endophytic fungi interactions and we also state the history of the discovery of the untapped potentialities of fungal secondary metabolites. Then, we highlight the huge importance of the discovered metabolites and their versatile applications in several vital fields including medicine, pharmacy, agriculture, industry and bioremediation. We then focus on the challenges and on the possible methods and techniques that can be used to help in the discovery of novel secondary metabolites. The latter range from endophytic selection and culture media optimization to more in-depth strategies such as omics, ribosome engineering and epigenetic remodeling.
Turbulent Superstructures in Inert Jets and Diffusion Jet Flames
Authors: Lemanov Vadim , Lukashov Vladimir , Sharov Konstantin
Published: December 2021

An experimental study of spatially localized very large-scale motion superstructures, propagating in a jet of carbon dioxide at low Reynolds numbers, was carried out. A hot-wire anemometer and a high-speed 2D PIV with a frequency of 7 kHz were used as measuring instruments. Such a puff-type superstructure in a jet with a longitudinal dimension of up to 20–30 nozzle diameters are initially formed in the jet source—a long tube in a laminar-turbulent transition mode (without artificial disturbances). It is shown that this regime with intermittency in time, when part of the time flow is laminar and the other part of time is turbulent, exists both at the exit from the nozzle and in the near field of the jet. Thus, the structural stability of such turbulent superstructures in the near field of the jet was found. Despite the large longitudinal scale, these formations have a transverse dimension of the order of several nozzle diameters. These structures have a complex internal topology, that is, superstructures are a conglomeration of vortices of different sizes from macroscale to microscale. Using the example of diffusion combustion of methane in air, it is demonstrated that in reacting jets, the existence of such large localized perturbations is a powerful physical mechanism for a global change in the flame topology. At the same time, the presence of a cascade of vortices of different sizes in the puff composition can lead to fractal deformation of the flame front.
Development of an Algorithm for Prediction of the Wind Speed in Renewable Energy Environments
Authors: Efthimiou George , Barmpas Fotios , Tsegas George , Moussiopoulos Nicolas
Published: December 2021

The aim of this work is to develop an algorithm that is able to provide predictions of wind speed statistics (WSS) in renewable energy environments. The subject is clearly interesting, as predictions of storms and extreme winds are important for decision makers and emergency response teams in renewable energy environments, e.g., in places where wind turbines could be located, including cities. The goal of the work is achieved through two phases: (a) During the preparation phase, the construction of a big WSS database based on computational fluid dynamics (CFD) is carried out, which includes flow fields of different wind directions in all grid numerical points; (b) In the second phase, the algorithm is used to find the records in the WSS database with the closest meteorological conditions to the meteorological conditions of interest. The evaluation of the CFD model (including both RANS and LES turbulence methodologies) is performed using the experimental data of the MUST (Mock Urban Setting Test) wind tunnel experiment.
Lower and Upper Bounds of Fractional Metric Dimension of Connected Networks
Authors: Javaid Muhammad , Aslam Muhammad Kamran , Asjad Muhammad Imran , Almutairi Bander N. , Inc Mustafa , Almohsen Bandar
Published: December 2021

The distance centric parameter in the theory of networks called by metric dimension plays a vital role in encountering the distance-related problems for the monitoring of the large-scale networks in the various fields of chemistry and computer science such as navigation, image processing, pattern recognition, integer programming, optimal transportation models and drugs discovery. In particular, it is used to find the locations of robots with respect to shortest distance among the destinations, minimum consumption of time, lesser number of the utilized nodes, and to characterize the chemical compounds, having unique presentations in molecular networks. After the arrival of its weighted version, known as fractional metric dimension, the rectification of distance-related problems in the aforementioned fields has revived to a great extent. In this article, we compute fractional as well as local fractional metric dimensions of web-related networks called by subdivided QCL, 2-faced web, 3-faced web, and antiprism web networks. Moreover, we analyse their final results using 2D and 3D plots.
Characterization of the Bacterial Community of Rumen in Dairy Cows with Laminitis
Authors: Guo Jian , Mu Ruiying , Li Shuang , Zhang Naisheng , Fu Yunhe , Hu Xiaoyu
Published: December 2021

Laminitis is the inflammation of the lamella, and it has caused great economic loss to the dairy industry and attracted wide attention around the world. In recent years, microbiota are considered to play a significant role in various diseases processes. Therefore, our study aimed to explore the characteristics of ruminal microbiota in laminitis cows. The serum of bovines with or without laminitis was collected to detect concentrations of lipopolysaccharide (LPS), lactic acid, and histamine, and ruminal fluid was collected for 16S rDNA sequence analysis. The results showed a significant increase in LPS and lactic acid levels in the laminitis group compared to the control group cows. In addition, a higher abundance of Candidatus Saccharimonas, Saccharofermentans, Erysipelotrichaceae UCG-009 genus, Acetobacter pasteurianus, Clostridium papyrosolvens, Ruminococcaceae bacterium AE2021, Porphyromonas crevioricanis, Pseudomonas boreopolis, Pseudomonas psychrotolerans, Rothia nasimurium, and Rothia pickettii was detected in the rumen fluid of laminitis bovines. In conclusion, this article confirms that there are differences in rumen microbiota between healthy and laminitis bovines. The elevated abundance of bacteria that enrich acid-enhancing metabolites, as well as increase the concentration of lactic acid and LPS, could be harmful factors to bovines and increase the risk of laminitis.
Factors Influencing Men’s Experiences and Engagement with the Rugby Fans in Training—New Zealand Pilot Trial: A Healthy Lifestyle Intervention for Men
Authors: Hargreaves Elaine Anne , Marsh Samantha , Maddison Ralph
Published: December 2021

Health promotion programs designed specifically to support men to improve their lifestyle behaviours are required to improve men’s health. This study explored factors that influenced men’s experiences of, and engagement with, the Rugby Fans in Training—New Zealand pilot trial, a professional sport-based healthy lifestyle intervention for overweight men. Thirty-five men (mean age = 45, SD = 10 years) who completed the 12-week intervention participated in one of eight semi-structured focus groups. Using inductive thematic analysis, five themes represented the meanings in the data. First, a group of like-minded men all in the same boat recognised the importance of being in similar life situations and having similar reasons for joining the programme. Second, the men described the importance of the support and motivation provided by the team atmosphere created through the programme. Third, the motivational coach recognised the characteristics, skills and knowledge of the coach delivering the programme which created engagement with it. Fourth, the education sessions were valued for the knowledge gained and underpinning philosophies that guided them. Finally, the involvement of the rugby franchise influenced commitment to the programme and created initial interest. These results provide evidence for the key components that should be incorporated into the future development of and improvement to healthy lifestyle interventions for men.
Longitudinal Associations of Substance Use Risk Profiles with the Use of Alternative Tobacco Products and Conventional Smoking among Adolescents
Authors: Hiemstra Marieke , Rozema Andrea , Jansen Maria , van Oers Hans , Mathijssen Jolanda
Published: December 2021

Although personality is associated with the onset of substance use (i.e., conventional smoking, alcohol use, and cannabis use) during adolescence, it is unclear whether personality traits are also associated with the onset of use of alternative tobacco products (ATPs), i.e., electronic cigarettes, shisha-pens, and water pipes. This study examines whether personality traits are associated with the onset of use of both conventional cigarettes and ATPs. Longitudinal data (baseline and 18-month follow-up) were used. The sample consisted of 1114 non-user adolescents (mean age = 13.36, SD = 0.93, 56% female) at baseline. To measure personality traits, the Substance Use Risk Profile Scale was used with four subscales: anxiety sensitivity, hopelessness, sensation seeking, and impulsivity. Structural equation models were conducted using Mplus 7.3. Results showed that both hopelessness and sensation seeking were associated with the onset of use of e-cigarettes and conventional cigarettes. Further, sensation seeking and impulsivity were associated with the onset of use of shisha-pens and water pipes. In conclusion, to prevent adolescents from using ATPs and/or conventional cigarettes, it is important to take their personality traits into account. More research on other (shared) risk factors and on more advanced stages of ATP use is needed before effective prevention strategies can be developed.
Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
Authors: Antonazzo Ippazio Cosimo , Fornari Carla , Maumus-Robert Sandy , Cei Eleonora , Paoletti Olga , Conti Sara , Cortesi Paolo Angelo , Mantovani Lorenzo Giovanni , Gini Rosa , Mazzaglia Giampiero
Published: December 2021

Background: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. Methods: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Results: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59–0.72) and ED access (0.72; 0.64–0.82), and a slight decrease of ASM prevalence (0.95; 0.94–0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96–0.98) and incidence (0.89; 0.80–0.99). Conclusion: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic.
Seated Virtual Reality-Guided Exercise Improved Gait in a Postoperative Hallux Valgus Case
Authors: Nakamoto Masami , Kakuda Akihiro , Miyashita Toshinori , Kitagawa Takashi , Kitano Masashi , Hara Masahiko , Kudo Shintarou
Published: December 2021

Virtual reality (VR)-guided exercise therapy using mediVR KAGURA has been reported to improve gait function by extending the arm to spatial targets while sitting. We aimed to investigate toe and trunk–pelvic function and plantar sensation during gait in a postoperative patient with hallux valgus. A 60-year-old woman, whose foot deformities had improved 6 months earlier, participated in the study. The exercise therapy interventions were performed twice weekly for 15 min. This study used an A-B-A design: 1-week pre-phase, 3-week intervention phase, and 2-week post-phase. The plantar pressure distribution and thoracic and pelvic displacements during gait were recorded at the end of each phase. The tactile pressure thresholds of the foot were determined before and after each exercise. The maximum force and impulse under the hallux increased after the intervention. The sensory threshold of the hallux was reduced. The amplitude of the thoracic and pelvic displacement was shortened in lateral and extended in the vertical and progressional directions after the intervention. We found that a 3-week VR-guided exercise improved toe function, plantar sensation, and postural adjustment of the trunk and pelvis during gait in a patient who had undergone surgery for hallux valgus, and the effects continued for 2 weeks.
Transfer of Macronutrients, Micronutrients, and Toxic Elements from Soil to Grapes to White Wines in Uncontaminated Vineyards
Authors: Richardson Justin B. , Chase Jahziel K.
Published: December 2021

Wine is a popular beverage and may be a source of nutrient and toxic elements during human consumption. Here, we explored the variation in nutrient and toxic elements from soils to grape berries and commercial white wines (Chardonnay) at five USA vineyards (New York, Vermont, California, Virginia) with strongly contrasting geology, soils, and climates. Samples were analyzed for macronutrients (Ca, K, and Mg), micronutrients (Mn, Cu, and Zn), and toxic elements (As, Cd, and Pb). Our study showed contrasting macronutrient, micronutrient, and toxic element concentrations in soils and in vines, leaves, and grapes. However, plant tissue concentrations did not correspond with total soil concentrations, suggesting a disconnect governing their accumulation. Bioconcentration factors for soil to grape berry transfer suggest the accumulation of Ca, K and Mg in berries while Fe, Mn, Cu, Zn, and Pb were generally not accumulated in our study or in previous studies. Wines from the five vineyards studied had comparable nutrient, micronutrient, and toxic metal concentrations as wines from Germany, Italy, Portugal, Spain, Croatia, Czech Republic, and Japan. The transfer of nutrients and toxic elements from grape berries to wine indicated that only Ca, K, and Mg were added or retained while concentrations of all other micronutrients and toxic elements were somewhat to extensively diminished. Thus, there appears to be a substantial effect on the geochemistry of the wine from the grape from either the fermentation process (i.e., flocculation), or a dilution effect. We conclude that soils, geology, and climate do not appear to generate a unique geochemical terroir as the transfer and concentration of inorganic nutrients appear to be comparable across strongly contrasting vineyards. This has several implications for human health. Nutrients in wine have potential impacts for human nutrition, as wine can meet or exceed the recommended dietary requirements of Ca, K, Mg, and Fe, and toxic metals As and Pb concentrations were also non-trivial.
Failure to Launch: Predictors of Unfavourable Physical Activity and Sedentary Behaviour Trajectories from Childhood to Adolescence: The Gateshead Millennium Study
Authors: Farooq Abdulaziz , Basterfield Laura , Adamson Ashley J. , Pearce Mark S. , Hughes Adrienne R. , Janssen Xanne , Wilson Mathew G. , Reilly John J.
Published: December 2021

In a previous study based on this cohort, only 15% of the participants belonged to a favourable physical activity/sedentary behaviour trajectory group (characterised by relatively high moderate–vigorous intensity physical activity and relatively low sedentary behaviour across childhood and adolescence). Since this favourable trajectory is protective against obesity, we aimed to identify factors associated with membership of this group. In this longitudinal study, 671 participants were assessed at ages 7, 9, 12 and 15 years. Participants’ demographics, socio-economic status (SES) and physical activity environment such as, sports club participation and commuting school were assessed at ages 7, 9 and 12 and analysed with favourable trajectory membership as an outcome using multinomial logistic regression. Sex (male) and SES (higher) were the non-modifiable factors associated with favourable trajectory group. Of the modifiable factors, commuting to school at age 7, a safe environment to play at age 7 and sports club participation at age 12 were all associated with more than 2.0 times increased probability of being in the most favourable trajectory. Future interventions to promote a favourable trajectory could focus on girls and participants with low SES. Promoting active commuting, safe local spaces to play and sports participation should also help lead to a favourable trajectory for physical activity and sedentary behaviour across childhood and adolescence.
Determination of Novel Anti-Cancer Agents by Targeting OGG1 Enzyme Using Integrated Bioinformatics Methods
Authors: Muhseen Ziyad Tariq , Ali Mustafa Hussein , Jaber Nawar Rushdi , Mashrea Dheyaa Shakir , Alfalki Ali Mamoon , Li Guanglin
Published: December 2021

The 8-oxoguanine DNA glycosylase (OGG1) enzyme is a key DNA glycosylase mediating the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from DNA molecule to the start base excision repair pathway. The OGG1 glycosylase function depletion has been seen to obstruct pathological conditions such as inflammation, A3 T-cell lymphoblastic acute leukemia growth, and neurodegenerative diseases, thus warranting OGG1 as an attractive anti-cancer enzyme. Herein, we employed several drug libraries intending to screen non-toxic inhibitory molecules against the active pocket of the enzyme that achieved stable binding mode in dynamics. Two anti-cancer compounds ([O-]C1=C(CC2=CC=CC=C2)SC(=[N+]1CC(=O)NC3=NC=C(CC4=CC=CC=C4)S3)S and CCCN(CCC)[S]-(=O)(=O)C1=CC=C(C=C1)C(=O)NNC2=NC3=CC=C(Br)C=C3C(=N2)C4=CC=CC=C4) from Selleckchem.com were identified to occupy the active pocket of OGG1 and bind with greater affinity than Control TH5487. The binding affinity of Top-1 is −11.6 kcal/mol while that of Top-2 is −10.7 kcal/mol in contrast to TH5487 Control (−9 kcal/mol). During molecular dynamic simulations versus time, the said compounds are tightly held by the enzyme with no minor structural deviations reported except flexible loops in particular those present at the N and C-terminal. Both the compounds produced extensive hydrophobic interactions with the enzyme along with stable hydrogen bonding. The docking and molecular dynamics simulations predictions were further validated by molecular mechanics with generalized Born and surface area solvation (MM/GBSA) and Poisson Boltzmann surface area (MM/PBSA), and WaterSwap binding energies that validated strong binding of the compounds to the enzyme. The MM/GBSA binding free energy for Top-1 complex is −28.10 kcal/mol, Top-2 complex is −50.14 kcal/mol) and Control is −46.91 kcal/mol while MM/PBSA value for Top-1, Top-2 and Control is −23.38 kcal/mol, −35.29 kcal/mol and −38.20 kcal/mol, respectively. Computational pharmacokinetics support good druglike candidacy of the compounds with acceptable profile of pharmacokinetics and very little toxicity. All these findings support the notion that the compounds can be used in experiments to test their anti-cancer activities.
Changes in Physical Fitness, Dietary Habits and Family Habits for Spanish Children during SARS-CoV-2 Lockdown
Authors: Ramos Álvarez Oliver , Arufe Giráldez Víctor , Cantarero Prieto David , Ibáñez García Alba
Published: December 2021

Background: habits related to diet and physical activity in children were modified due to the lockdown that Spain had between March and June 2019 because of the health crisis caused by the appearance of SARS-CoV-2. The aim of the study was to know the impact that the lockdown had on physical fitness values in children aged 11–12. Methods: the study consisted of 50 Spanish children aged 11–12 (M = 11.40; SD = 0.50), 33 (66%) boys and 17 (34%) girls. Data collection was performed using the Alpha-Fitness Battery, a validated instrument to assess dietary intake, habits and practices, and an ad hoc survey to collect sociodemographic data and other information relevant to the study. Results: there were significant differences (p < 0.05) in the results of fitness variables measured in the standing long jump, agility speed and aerobic capacity, as well as in the results of maximal oxygen uptake (VO2 max) between, before and after lockdown in both boys and girls. No significant differences were found in measurements of right and left hand grip (p > 0.05). Conclusions: there is evidence of a significant impact of SARS-CoV-2 lockdown on physical fitness values in boys and girls aged 11–12.
Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population
Authors: Chernyak Boris V. , Lyamzaev Konstantin G. , Mulkidjanian Armen Y.
Published: December 2021

In humans, over-activation of innate immunity in response to viral or bacterial infections often causes severe illness and death. Furthermore, similar mechanisms related to innate immunity can cause pathogenesis and death in sepsis, massive trauma (including surgery and burns), ischemia/reperfusion, some toxic lesions, and viral infections including COVID-19. Based on the reviewed observations, we suggest that such severe outcomes may be manifestations of a controlled suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than an aberrant hyperstimulation of defense responses. We argue that innate immunity may be involved in the implementation of an altruistic programmed death of an organism aimed at increasing the well-being of the whole community. We discuss possible ways to suppress this atavistic program by interfering with innate immunity and suggest that combating this program should be a major goal of future medicine.
Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study
Authors: Spisz Paulina , Chylewska Agnieszka , Królicka Aleksandra , Ramotowska Sandra , Dąbrowska Aleksandra , Makowski Mariusz
Published: December 2021

Antibiotic resistance is a global problem, and one promising solution to overcome this issue is using metallodrugs, which are drugs containing metal ions and ligands. These complexes are superior to free ligands in various characteristics including anticancer properties and mechanism of action. The pharmacological potential of metallodrugs can be modulated by the appropriate selection of ligands and metal ions. A good example of proper coordination is the combination of sulfonamides (sulfamerazine, sulfathiazole) with a ruthenium(III) ion. This work aimed to confirm that the activity of sulfonamides antibacterial drugs is initiated and/or stimulated by their coordination to an Ru(III) ion. The study determined the structure, electrochemical profile, CT-DNA affinity, and antimicrobial as well as anticancer properties of the synthesized complexes. The results proved that Ru(III) complexes exhibited better biological properties than the free ligands.