bluuebunny/crossref_metadata_2025 huggingface dataset:
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Authors: Ellebrecht Christoph T. , Bhoj Vijay G. , Nace Arben , Choi Eun Jung , Mao Xuming , Cho Michael Jeffrey , Di Zenzo Giovanni , Lanzavecchia Antonio , Seykora John T. , Cotsarelis George , Milone Michael C. , Payne Aimee S.
Published: July 2016

Engineering T cells to treat autoimmunity

Autoimmune diseases such as lupus and rheumatoid arthritis lack therapies that specifically target only the disease-causing cells. Inspired by the clinical success of using chimeric antigen receptor T cells to treat certain types of cancers, Ellebrecht
et al.
asked whether a similar approach might also work against antibody-driven autoimmune diseases. They engineered T cells to express chimeric receptors consisting of the disease-causing autoantigen desmoglein 3 fused to signaling domains that activate T cells. When given to diseased mice, the engineered T cells targeted and killed B cells that express antibodies targeting desmoglein 3, hinting that such a strategy may be an effective way to treat antibody-driven autoimmune diseases.

Science
, this issue p.
179
Promoting CNS repair
Authors: Cameron Evan G. , Goldberg Jeffrey L.
Published: July 2016

What influences glial and neuronal response to neurodegeneration?
Draft Genome Sequence of 16SrIII-J Phytoplasma, a Plant Pathogenic Bacterium with a Broad Spectrum of Hosts
Authors: Zamorano Alan , Fiore Nicola
Published: July 2016

Phytoplasmas are bacterial plant pathogens that can affect different vegetal hosts. In South America, a phytoplasma belonging to ribosomal subgroup 16SrIII-J has been reported in many crops. Here we report its genomic draft sequence, showing a total length of 687,253 bp and a G+C content of 27.72%.
Complete Genome Sequences of Four Isolates of
Plutella xylostella
Granulovirus
Authors: Spence Robert J. , Noune Christopher , Hauxwell Caroline
Published: July 2016

Granuloviruses are widespread pathogens of
Plutella xylostella
L. (diamondback moth) and potential biopesticides for control of this global insect pest. We report the complete genomes of four
Plutella xylostella
granulovirus isolates from China, Malaysia, and Taiwan exhibiting pairs of noncoding, homologous repeat regions with significant sequence variation but equivalent length.
Genome Sequence of the Historical Clinical Isolate Burkholderia pseudomallei PHLS 6
Authors: D'haeseleer Patrik , Johnson Shannon L. , Davenport Karen W. , Chain Patrick S. , Schoeniger Joe , Ray Debjit , Sinha Anupama , Williams Kelly P. , Peña José , Branda Steven S. , El-Etr Sahar
Published: July 2016

Here, we present the draft genome sequence of
Burkholderia pseudomallei
PHLS 6, a virulent clinical strain isolated from a melioidosis patient in Bangladesh in 1960. The draft genome consists of 39 contigs and is 7,322,181 bp long.
Regulatory approval of pharmaceuticals without a randomised controlled study: analysis of EMA and FDA approvals 1999–2014
Authors: Hatswell Anthony J , Baio Gianluca , Berlin Jesse A , Irs Alar , Freemantle Nick
Published: July 2016

Introduction

The efficacy of pharmaceuticals is most often demonstrated by randomised controlled trials (RCTs); however, in some cases, regulatory applications lack RCT evidence.

Objective

To investigate the number and type of these approvals over the past 15 years by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).

Methods

Drug approval data were downloaded from the EMA website and the ‘Drugs@FDA’ database for all decisions on pharmaceuticals published from 1 January 1999 to 8 May 2014. The details of eligible applications were extracted, including the therapeutic area, type of approval and review period.

Results

Over the period of the study, 76 unique indications were granted without RCT results (44 by the EMA and 60 by the FDA), demonstrating that a substantial number of treatments reach the market without undergoing an RCT. The majority was for haematological malignancies (34), with the next most common areas being oncology (15) and metabolic conditions (15). Of the applications made to both agencies with a comparable data package, the FDA granted more approvals (43/44 vs 35/44) and took less time to review products (8.7 vs 15.5 months). Products reached the market first in the USA in 30 of 34 cases (mean 13.1 months) due to companies making FDA submission before EMA submissions and faster FDA review time.

Discussion

Despite the frequency with which approvals are granted without RCT results, there is no systematic monitoring of such treatments to confirm their effectiveness or consistency regarding when this form of evidence is appropriate. We recommend a more open debate on the role of marketing authorisations granted without RCT results, and the development of guidelines on what constitutes an acceptable data package for regulators.
Searching for composite Higgs models at the LHC
Authors: Flacke Thomas
Published: July 2016

Composite Higgs models have the potential to provide a solution to the hierarchy problem and a dynamical explanation for the generation of the Higgs potential. They can be tested at the LHC as the new sector which underlies electroweak symmetry breaking must become strong in the TeV regime, which implies additional bound states beyond the Higgs. In this paper, we first discuss prospects and search strategies for top partners (and other quark partners) in the strongly coupled sector, which we study in an effective field theory setup. In the second part of the proceedings, we go beyond the effective field theory approach. We discuss potential UV embeddings for composite Higgs models which contain a Higgs as well as top partners. We show that in all of these models, additional pseudo-Nambu–Goldstone bosons beyond the Higgs are present. In particular, all of the models contain a pseudoscalar which couples to the Standard Model gauge fields through Wess–Zumino–Witten terms, providing a prime candidate for a di-boson (including a di-photon) resonance. The models also contain colored pNGBs which can be searched for at the LHC.
Quasi-periodic wave solutions and asymptotic properties for a fifth-order Korteweg–de Vries type equation
Authors: Qin Chun-Yan , Tian Shou-Fu , Wang Xiu-Bin , Zhang Tian-Tian
Published: July 2016

Under investigation in this paper is a fifth-order Korteweg–de Vries type (fKdV-type) equation with time-dependent coefficients, which can be used to describe many nonlinear phenomena in fluid mechanics, ocean dynamics and plasma physics. The binary Bell polynomials are employed to find its Hirota’s bilinear formalism with an extra auxiliary variable, based on which its [Formula: see text]-soliton solutions can be also directly derived. Furthermore, by considering multi-dimensional Riemann theta function, a lucid and straightforward generalization of the Hirota–Riemann method is presented to explicitly construct the multiperiodic wave solutions of the equation. Finally, the asymptotic properties of these periodic wave solutions are strictly analyzed to reveal the relationships between periodic wave solutions and soliton solutions.
Traffic chaotic dynamics modeling and analysis of deterministic network
Authors: Wu Weiqiang , Huang Ning , Wu Zhitao
Published: July 2016

Network traffic is an important and direct acting factor of network reliability and performance. To understand the behaviors of network traffic, chaotic dynamics models were proposed and helped to analyze nondeterministic network a lot. The previous research thought that the chaotic dynamics behavior was caused by random factors, and the deterministic networks would not exhibit chaotic dynamics behavior because of lacking of random factors. In this paper, we first adopted chaos theory to analyze traffic data collected from a typical deterministic network testbed — avionics full duplex switched Ethernet (AFDX, a typical deterministic network) testbed, and found that the chaotic dynamics behavior also existed in deterministic network. Then in order to explore the chaos generating mechanism, we applied the mean field theory to construct the traffic dynamics equation (TDE) for deterministic network traffic modeling without any network random factors. Through studying the derived TDE, we proposed that chaotic dynamics was one of the nature properties of network traffic, and it also could be looked as the action effect of TDE control parameters. A network simulation was performed and the results verified that the network congestion resulted in the chaotic dynamics for a deterministic network, which was identical with expectation of TDE. Our research will be helpful to analyze the traffic complicated dynamics behavior for deterministic network and contribute to network reliability designing and analysis.
DEPOSITION AND CHARACTERIZATION OF MAGNETRON CO-SPUTTERED InAlN FILM AT DIFFERENT Ar:N2 GAS FLOW RATIOS
Authors: AFZAL NAVEED , DEVARAJAN MUTHARASU , IBRAHIM KAMARULAZIZI
Published: July 2016

This work presents the influence of changing Ar:N2 gas ratio on the growth and properties of InAlN films. InAlN films were deposited on [Formula: see text]-type Si(111) substrates by using magnetron co-sputtering method in 6:12, 10:10, 12:8 and 12:6 Ar:N2 mixtures at 300[Formula: see text]C. The surface, structural, electrical and optical properties of the deposited films were evaluated at different Ar:N2 ratios. The grain size and film thickness were increased by increasing the Ar flow with respect to N2. Structural characterization by X-ray diffraction (XRD) revealed an improvement in the crystalline quality of the [Formula: see text]-axis-oriented InAlN film by adjusting the Ar:N2 ratio to 12:8, however no diffraction peak corresponding to InAlN was detected at 6:12 Ar:N2 mixture. The surface roughness of InAlN film exhibited an increasing trend whereas the electrical resistivity of the film was decreased by increasing the Ar:N2 ratio. The bandgap of InAlN film was calculated from the optical reflectance spectra and it was found to change by changing the Ar:N2 gas ratio. The analysis of results from this work shows that the InAlN film with improved physical properties can be obtained through reactive magnetron co-sputtering method by adjusting the Ar:N2mixture to 12:8.
Maximal and prime k-subsemimodules in semimodules over semirings
Authors: Han Song-Chol
Published: July 2016

For a semimodule over any semiring, the maximal and prime [Formula: see text]-subsemimodules are characterized with the help of the quotient structure. The main results are as follows. A semimodule is [Formula: see text]-congruence-simple iff it is [Formula: see text]-subsemimodule-simple. A nonzero semimodule is [Formula: see text]-simple iff it satisfies condition [Formula: see text]. A proper [Formula: see text]-subsemimodule of a semimodule is a maximal [Formula: see text]-subsemimodule iff the quotient semimodule is [Formula: see text]-simple. A proper [Formula: see text]-subsemimodule is prime in a semimodule iff the quotient semimodule is prime. A nonzero [Formula: see text]-simple semimodule over a commutative semiring is prime. Lemma 6.2 in this paper corrects the statement and proof of Lemma 3.16 in [Yeşilot Hacet. J. Math. Stat. 39 (2010) 305–312].
The continuous wavelet transform in n-dimensions
Authors: Pandey J. N. , Jha N. K. , Singh O. P.
Published: July 2016

Daubechies obtained the [Formula: see text]-dimensional inversion formula for the continuous wavelet transform of spherically symmetric wavelets in [Formula: see text] with convergence interpreted in the [Formula: see text]-norm. From the wavelet [Formula: see text], Daubechies generated a doubly indexed family of wavelets [Formula: see text] by restricting the dilation parameter [Formula: see text] to be a real number greater than zero and the translation parameter [Formula: see text] belonging to [Formula: see text]. We show that [Formula: see text] can be chosen to be in [Formula: see text] with none of the components [Formula: see text] vanishing. Further, we prove that if [Formula: see text] and [Formula: see text] are continuous in [Formula: see text], then the convergence besides being in [Formula: see text] is also pointwise in [Formula: see text]. We advance our theory further to the case when [Formula: see text] and [Formula: see text] both belong to [Formula: see text] then convergence of the wavelet inversion formula is pointwise at all points of continuity of [Formula: see text]. This result significantly enhances the applicability of the wavelet inversion formula to the image processing.
Lattice points in a circle for generic unimodular shears
Authors: Kelmer Dubi
Published: July 2016

Given a unimodular lattice [Formula: see text] consider the counting function [Formula: see text] counting the number of lattice points of norm less than [Formula: see text], and the remainder [Formula: see text]. We give an elementary proof that the mean square of the remainder over the set of all shears of a unimodular lattice is bounded by [Formula: see text].
Computing dimensions of spaces of Arakelov divisors of number fields
Authors: Tran Ha Thanh Nguyen
Published: July 2016

The function [Formula: see text] for a number field is analogous to the dimension of the Riemann–Roch spaces at divisors on an algebraic curve. We provide a method to compute this function for number fields with unit group of rank at most 2, even with large discriminant. This method is based on using LLL-reduced bases, the “jump algorithm” and Poisson summation formula.
Comparisons between Dual and Tri Material Gate on a 32 nm Double Gate MOSFET
Authors: Dasgupta Arpan , Das Rahul , Chakraborty Shramana , Dutta Arka , Kundu Atanu , Sarkar Chandan K.
Published: July 2016

The paper reports a comparative analysis between the dual material gate double gate (DMG-DG) nMOSFET and the tri material gate double gate (TMG-DG) nMOSFET in terms of their analog and RF performance. Three different devices having the DMG-DG structure have been considered. Each of the devices have different higher workfunction material gate length (L1) to lower workfunction material gate length (L2) ratio (L1:L2). Along with the three devices, the performance of the TMG-DG nMOSFET is compared. The analog parameters considered for the comparison are the drain current ([Formula: see text]), the transconductance ([Formula: see text]), the transconductance generation factor ([Formula: see text]/[Formula: see text]) and the intrinsic gain ([Formula: see text]Ro). The drain induced barrier lowering (DIBL) of the devices is compared. The RF analysis is performed using the non quasi static (NQS) approach. We consider the intrinsic gate to source capacitances ([Formula: see text]), the intrinsic gate to drain capacitance ([Formula: see text]), the intrinsic gate to source resistances ([Formula: see text]), the intrinsic gate to drain resistance ([Formula: see text]), the transport delay ([Formula: see text]), the unity current gain cut-off frequency ([Formula: see text]) and the max frequency of oscillation ([Formula: see text]) for the RF comparisons. A single stage amplifier is also implemented using the devices for a circuit comparison.
A new evaluation model of comprehensive radio frequency stealth performance of radar
Authors: Zhao Yang , Shang Chaoxuan , Han Zhuangzhi , Wang Pin
Published: July 2016

The detection capabilities of passive electronic warfare reconnaissance equipment have substantially increased during recent years. Correspondingly, the radar equipment is required to take various means to improve the radio frequency (RF) stealth performance to ensure the transmitted RF signal does not get intercepted. However, traditional evaluation methods on RF stealth performance cannot accurately evaluate the RF stealth capabilities of new system radar. In this study, a joint interception probability evaluation model on RF stealth performance was established, which divided the interception process into two parts: front interception and system interception. Various RF stealth means adopted by different radar equipment were taken into consideration to improve the applicability of this model. Simulation results show that this model is able to effectively characterize almost all the aspects of the RF stealth features and can serve as a good reference to evaluate RF radar stealth performance comprehensively.
Molecular Design of Bioinspired Nanostructures for Biomedical Applications: Synthesis, Self-Assembly and Functional Properties
Authors: Xu Hesheng Victor , Zheng Xin Ting , Mok Beverly Yin Leng , Ibrahim Salwa Ali , Yu Yong , Tan Yen Nee
Published: July 2016

Biomolecules are the nanoscale building blocks of cells, which play multifaceted roles in the critical biological processes such as biomineralization in a living organism. In these processes, the biological molecules such as protein and nucleic acids use their exclusive biorecognition properties enabled from their unique chemical composition, shape and function to initiate a cascade of cellular events. The exceptional features of these biomolecules, coupled with the recent advancement in nanotechnology, have led to the emergence of a new research field that focuses on the molecular design of bioinspired nanostructures that inherit the extraordinary function of natural biomaterials. These “bioinspired” nanostructures could be formulated by biomimetic approaches through either self-assembling of biomolecules or acting as a biomolecular template/precursor to direct the synthesis of nanocomposite. In either situation, the resulting nanomaterials exhibit phenomenal biocompatibility, superb aqueous solubility and excellent colloidal stability, branding them exceptionally desirable for both in vitro and in vivo biomedical applications. In this review, we will present the recent developments in the preparation of “bioinspired” nanostructures through biomimetic self-assembly and biotemplating synthesis, as well as highlight their functional properties and potential applications in biomedical diagnostics and therapeutic delivery. Lastly, we will conclude this topic with some personal perspective on the challenges and future outlooks of the “bioinspired” nanostructures for nanomedicine.
Topology Optimization for Architected Materials Design
Authors: Osanov Mikhail , Guest James K.
Published: July 2016

Advanced manufacturing processes provide a tremendous opportunity to fabricate materials with precisely defined architectures. To fully leverage these capabilities, however, materials architectures must be optimally designed according to the target application, base material used, and specifics of the fabrication process. Computational topology optimization offers a systematic, mathematically driven framework for navigating this new design challenge. The design problem is posed and solved formally as an optimization problem with unit cell and upscaling mechanics embedded within this formulation. This article briefly reviews the key requirements to apply topology optimization to materials architecture design and discusses several fundamental findings related to optimization of elastic, thermal, and fluidic properties in periodic materials. Emerging areas related to topology optimization for manufacturability and manufacturing variations, nonlinear mechanics, and multiscale design are also discussed.
Raman Studies of Carbon Nanostructures
Authors: Jorio Ado , Souza Filho Antonio G.
Published: July 2016

This article reviews recent advances on the use of Raman spectroscopy to study and characterize carbon nanostructures. It starts with a brief survey of Raman spectroscopy of graphene and carbon nanotubes, followed by recent developments in the field. Various novel topics, including Stokes–anti-Stokes correlation, tip-enhanced Raman spectroscopy in two dimensions, phonon coherence, and high-pressure and shielding effects, are presented. Some consequences for other fields—quantum optics, near-field electromagnetism, archeology, materials and soil sciences—are discussed. The review ends with a discussion of new perspectives on Raman spectroscopy of carbon nanostructures, including how this technique can contribute to the development of biotechnological applications and nanotoxicology.
Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer
Authors: Xing Fei , Liu Yin , Sharma Sambad , Wu Kerui , Chan Michael D. , Lo Hui-Wen , Carpenter Richard L. , Metheny-Barlow Linda J. , Zhou Xiaobo , Qasem Shadi A. , Pasche Boris , Watabe Kounosuke
Published: July 2016

Brain metastasis is one of the chief causes of mortality in breast cancer patients, but the mechanisms that drive this process remain poorly understood. Here, we report that brain metastatic cells expressing high levels of c-Met promote the metastatic process via inflammatory cytokine upregulation and vascular reprogramming. Activated c-Met signaling promoted adhesion of tumor cells to brain endothelial cells and enhanced neovascularization by inducing the secretion of IL8 and CXCL1. Additionally, stimulation of IL1β secretion by activation of c-Met induced tumor-associated astrocytes to secrete the c-Met ligand HGF. Thus, a feed-forward mechanism of cytokine release initiated and sustained by c-Met fed a vicious cycle that generated a favorable microenvironment for metastatic cells. Reinforcing our results, we found that pterostilbene, a compound that penetrates the blood–brain barrier, could suppress brain metastasis by targeting c-Met signaling. These findings suggest a potential utility of this natural compound for chemoprevention. Cancer Res; 76(17); 4970–80. ©2016 AACR.
MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: July 2016

Epithelial–mesenchymal transition (EMT) is an essential mechanism of metastasis, including in colorectal cancer. Although EMT processes are often triggered in cancer cells by their surrounding microenvironment, how EMT-relevant genes control these processes is not well understood. In multiple types of cancers, the transcription factor MEF2D has been implicated in cell proliferation, but its contributions to metastasis have not been addressed. Here, we show MEF2D is overexpressed in clinical colorectal cancer tissues where its high expression correlates with metastatic process. Functional investigations showed that MEF2D promoted cancer cell invasion and EMT and that it was essential for certain microenvironment signals to induce EMT and metastasis in vivo. Mechanistically, MEF2D directly regulated transcription of the EMT driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter. More importantly, MEF2D responded to various tumor microenvironment signals and acted as a central integrator transducing multiple signals to activate ZEB1 transcription. Overall, our results define a critical function for MEF2D in upregulating EMT and the metastatic capacity of colorectal cancer cells. Further, they offer new insights into how microenvironment signals activate EMT-relevant genes and deepen the pathophysiologic significance of MEF2D, with potential implications for the prevention and treatment of metastatic colorectal cancer. Cancer Res; 76(17); 5054–67. ©2016 AACR.
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib
Authors: Miller Rowan E. , Brough Rachel , Bajrami Ilirjana , Williamson Chris T. , McDade Simon , Campbell James , Kigozi Asha , Rafiq Rumana , Pemberton Helen , Natrajan Rachel , Joel Josephine , Astley Holly , Mahoney Claire , Moore Jonathan D. , Torrance Chris , Gordan John D. , Webber James T. , Levin Rebecca S. , Shokat Kevan M. , Bandyopadhyay Sourav , Lord Christopher J. , Ashworth Alan
Published: July 2016

New targeted approaches to ovarian clear cell carcinomas (OCCC) are needed, given the limited treatment options in this disease and the poor response to standard chemotherapy. Using a series of high-throughput cell-based drug screens in OCCC tumor cell models, we have identified a synthetic lethal (SL) interaction between the kinase inhibitor dasatinib and a key driver in OCCC, ARID1A mutation. Imposing ARID1A deficiency upon a variety of human or mouse cells induced dasatinib sensitivity, both in vitro and in vivo, suggesting that this is a robust synthetic lethal interaction. The sensitivity of ARID1A-deficient cells to dasatinib was associated with G1–S cell-cycle arrest and was dependent upon both p21 and Rb. Using focused siRNA screens and kinase profiling, we showed that ARID1A-mutant OCCC tumor cells are addicted to the dasatinib target YES1. This suggests that dasatinib merits investigation for the treatment of patients with ARID1A-mutant OCCC. Mol Cancer Ther; 15(7); 1472–84. ©2016 AACR.
Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination
Authors: Fromm George , de Silva Suresh , Giffin Louise , Xu Xin , Rose Jason , Schreiber Taylor H.
Published: July 2016

T-cell costimulation typically occurs in a defined microenvironment that is not recapitulated by agonistic antibody therapy. To deliver such stimulation under more favorable conditions, we investigated whether an allogeneic cell-based vaccine that secreted Fc-OX40L, Fc-ICOSL, or Fc-4-1BBL would activate and expand T cells comparably with systemically administered agonist antibodies. Among these costimulators, locally secreted Fc-OX40L provided superior priming of antigen-specific CD8+ T cells, compared with combinations with OX40 antibodies or vaccine alone. Vaccine-expressed Fc-OX40L also stimulated IFNγ, TNFα, granzyme B, and IL2 by antigen-specific CD8+ T cells similarly to OX40 antibodies, without off-target consequences such as proinflammatory cytokine induction. Vaccine-secreted Fc-OX40L increased CD127+KLRG-1− memory precursor cells during the contraction phase, resulting in improved proliferation upon secondary antigen challenge, as compared with OX40 antibody. A cell-based vaccine cosecreting gp96-Ig and Fc-OX40L led to even more pronounced tumor control, complete tumor rejection, and increased tumor antigen–specific T-cell proliferation, including in tumor-infiltrating lymphocytes, as compared with combinations of gp96-Ig vaccine and OX40 antibodies, in mice with established melanoma or colorectal carcinoma. These data suggest that local modulation of the vaccine microenvironment has unexpected advantages over systemic costimulation with agonistic antibodies, which may simplify the clinical translation of such combination immunotherapies into humans. Cancer Immunol Res; 4(9); 766–78. ©2016 AACR.
PID Controller Response to Set-Point Change in DC-DC Converter Control
Authors: Ibrahim Oladimeji , Yahaya Nor Zaihar B , Saad Nordin
Published: July 2016

Power converter operations and efficiency is affected by variation in supply voltage, loads current, circuit elements, ageing and temperature.  To meet the objective of tight voltage regulation, power converters circuit module and the control unit must be robust to reject disturbances arising from supply, load variation and changes in circuit elements. PID controller has been the most widely used in power converter control. This paper presents studies of robustness of PID controller tuning methods to step changes in the set point and disturbance rejection in power converter control. A DC-DC boost converter was modelled using averaged state-space mothod and PID controllers were designed with five different tuning methods. The study reveals the transient response and disturbance rejection capability of each tuning methods for their suitability in power supply design applications.
Memorial do convento, ou a memória que resgata os esquecidos
Authors: Recchia Márcio Aurélio
Published: July 2016

Este artigo tem como objetivo levantar algumas reflexões acerca dos “ausentes da história”, tema do filósofo Paul Ricoeur, bem como sobre a questão da corveia anônima, discutida por Walter Benjamin, presentes no romance Memorial do convento de José Saramago
Ser habitada por Timor
Authors: Gonzalez Suillan Miguez
Published: July 2016

A ideia do presente texto é que num primeiro momento o leitor entre em contato com a dimensão da invasão indonésia junto ao território timorense e conheça as vozes de Xanana Gusmão, João Aparício e Domingos de Sousa por meio da literatura produzida para a manutenção do espírito da resistência, revelando, com isso, as mais cruéis ações humanas praticadas para a imposição da anexação da ilha de Timor, em contrapartida da necessidade de reconquista da pátria para o cessar da opressão. Somadas a tais vozes, reconhecidos escritores, como Mia Couto, Sophia Andresen, Craveirinha e Agualusa ofereceram prefácios às obras como gesto solidário à luta pela liberdade da nação, forjando uma rede literária. O segundo momento refere-se à experiência de viver no Timor pós-independência, por seis meses, o que justifica o estudo oferecido e a promessa feita aos timorenses de que não seriam esquecidos por mim, seriam lidos e admirados: minha tese de doutorado, em andamento, faz do país e de seu povo objeto de estudo e apreciação, na torcida por mais interessados. Adianto que o relato vem acompanhado por imagens de meu arquivo pessoal, é bem-intencionado e repleto de engasgos não evitados, porque Timor foi o meu despertar.
A arquitetura de Luís Saia
Authors: Janjulio Maristela da Silva
Published: July 2016

Apesar do pequeno número de projetos de arquitetura da autoria de Luís Saia encontrados - a maior parte, residências, nem todos construídos -, sua análise se enriquece ao serem confrontados com seus textos sobre arquitetura, ambos dos anos 1950. Percebe-se uma sintonia entre suas reflexões e projetos e o panorama da arquitetura brasileira e internacional da época. Mas, talvez a questão mais interessante sejam suas considerações sobre o processo de projeto, que transparecem em sua atividade projetual. Na complexidade desse processo, ele medita sobre o papel da racionalidade e da técnica, mas, especialmente, sobre o lugar da dimensão criadora, da imaginação poética.
Luís Saia e a formação de uma geração
Authors: Sodré João Clark de A.
Published: July 2016

Ao mapear o campo de atuação de Luís Saia para além de seus trabalhos junto de preservação e restauração do patrimônio histórico em São Paulo, o artigo procurou situá-lo dentro do quadro mais amplo de sua geração. A partir deste entendimento, foi possível discorrer sobre sua contribuição na formação do novos arquitetos a partir dos anos 50, com a criação da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo (FAU- USP), reconhecendo o dispositivo da viagem como uma experiência formativa fundamental, tanto para a nova quanto para sua geração.
Cartografia dos Centros de Convivência: a produção de encontros e redes
Authors: Ferigato Sabrina Helena , Carvalho Sergio Resende , Teixeira Ricardo Rodrigues
Published: July 2016

O presente estudo tem como objeto a produção dos Centros de Convivência (CECOs) na rede intersetorial, tendo o município de Campinas como campo empírico. O objetivo principal do estudo foi identificar, dar visibilidade e analisar a produção dos Centros de Convivência, a partir de uma abordagem qualitativa e do método da cartografia. Adotou como referência teórica a Filosofia da Diferença e os pressupostos da Atenção Psicossocial. Dos resultados se destacou a produção de encontros, como aspecto central da produção dos CECOs: encontros na diferença, o encontro entre usuários com heterogeneidade etária, de gênero e de diagnóstico; o encontro entre profissionais e usuários; o encontro entre diferentes disciplinas, setores e saberes; o encontro com diferentes atividades e o encontro com a cidade.
Autonomia e independência: percepção de adolescentes com deficiência visual e de seus cuidadores
Authors: Nascimento Gabriela Cordeiro Corrêa do , Burnagui Jhenifer Geisa , Rosa Mariana Peres da
Published: July 2016

A deficiência visual constitui-se como fator limitante para a aquisição de funções e habilidades essenciais em todas as fases de desenvolvimento. Considerando que a adolescência se constitui como fase de vida marcada por transições, pela construção de identidade própria e conquista de autonomia e independência, para o adolescente com deficiência visual, esta etapa de vida pode ser marcada por maiores dificuldades na aquisição destas habilidades, destacando, ainda, que a família possui papel central neste contexto. Buscou-se com este estudo analisar se há diferenças entre as percepções de adolescentes com deficiência visual e de seus cuidadores quanto às vivências e experiências de autonomia e independência desses indivíduos. Para tanto, foi necessário identificar a compreensão dos participantes quanto aos termos autonomia e independência. A fim de atingirem-se os objetivos, foi utilizada a metodologia de pesquisa qualitativa exploratória-descritiva. Obteve-se dissonâncias entre os entendimentos dos termos, porém, após a explicação dos conceitos adotados para este estudo, todos os participantes descreveram os adolescentes como autônomos e independentes e não existiram discrepâncias quanto às percepções das vivências dos mesmos. Contudo, considera-se necessário a realização de mais pesquisas nesta área, visto a relevância da conceituação dos termos autonomia e independência para a Terapia Ocupacional e a escassez de publicações encontrada.
Mapeamento de recursos de tecnologia assistiva utilizados por idosos
Authors: Gradim Luma Carolina Câmara , Castro Shamyr Sulyvan de , Tavares Darlene Mara dos Santos , Cavalcanti Alessandra
Published: July 2016

O aumento da expectativa de vida populacional no Brasil evidencia também o número de pessoas que envelhecem apresentando perda da capacidade funcional e aumento da dependência nas atividades do dia a dia. A tecnologia assistiva (TA) se constitui como suporte para que os idosos mantenham a independência e funcionalidade. Os objetivos deste estudo foram: (i) elencar os recursos de tecnologia assistiva utilizados por idosos assistidos em uma unidade matricial de saúde (UMS) no município de Uberaba/MG; (ii) descrever as características sócio-econômicas e as doenças crônicas por eles relatadas e (iii) estudar a área de ocupação – atividades de vida diária e a categoria dos recursos da tecnologia assistiva usados. Participaram do estudo 144 idosos com 60 anos ou mais. Para a coleta dos dados foram aplicados dois instrumentos estruturados idealizados pelos autores. Os resultados evidenciaram utilização de tecnologia assistiva aquém das necessidades para manutenção do desempenho funcional dos idosos, com exceção do uso de óculos. A idade média dos participantes foi de 72,4 anos (±7,8) e houve predomínio de idosos do gênero feminino. Os diagnósticos clínicos relatados foram na maioria casos de hipertensão arterial. Dos participantes, 140 (97,2%) relataram utilizar um tipo de recurso de TA como auxílio em alguma atividade de vida diária.
As residências terapêuticas e a clínica do cotidiano: contribuições da terapia ocupacional.
Authors: Ferigato Sabrina Helena , Ballarin Maria Luisa Gazabin Simões , Marcolino Taís Quevedo , Indianni Sandrina Kellen
Published: July 2016

O objeto desse relato de experiência é a atuação da Terapia Ocupacional junto às Residências Terapêuticas. Temos como objetivo a sistematização dessa atuação a partir da descrição e análise do trabalho de terapeutas ocupacionais nestes serviços. Para isso, partimos da valorização da dimensão da experiência de terapeutas ocupacionais vinculados a Serviços Residenciais Terapêuticos e a aproximação de seus registros. Esses registros foram construídos como diários de campo e posteriormente analisados. Para a análise de dados utilizamos o método de avaliação de diários de campo, proposto por Lourau, partindo do referencial teórico da Clínica Psicossocial, da Análise Institucional e referencias do cotidiano propostos na Terapia Ocupacional. Como resultados, apresentaremos a sistematização da atuação da terapia ocupacional em serviços residenciais a partir de 4 planos: (1) intervenções na casa; (2) intervenções junto aos moradores; (3) ações no território e na comunidade; (4) ações junto à equipe de trabalho e à rede intersetorial. Esses planos, quando articulados na discussão e considerações finais, apontam para a potência que as especificidades do núcleo da terapia ocupacional podem trazer para as ações realizadas nos serviços residenciais terapêuticos, especialmente no se refere à abordagem psicossocial com ênfase no cotidiano e nos processos de desisntitucionalização.
O PROBLEMA ENVOLVENDO AS OPMEs E OS PLANOS DE SAÚDE: CONTORNOS E ANÁLISE DA PROBLEMÁTICA
Authors: Martins Paulo Roberto do Nascimento , Dahinten Bernardo Franke , Dahinten Augusto Franke
Published: July 2016

O presente artigo tem como objetivo introduzir e analisar algumas das questões mais polêmicas relacionadas às indicações de Órteses, Próteses e Materiais Especiais (OPMEs) no âmbito dos contratos de planos de saúde. No texto, são exibidos elementos normativos atinentes a esse contexto, bem como decisões judiciais emblemáticas acerca da temática. O escopo é defender, de forma fundamentada, que a indicação de próteses e órteses pelo profissional assistente não pode ser vista como a única opinião válida, tampouco como necessariamente a mais correta, haja vista a existência de interesses outros que não a mera saúde do paciente e que também estão frequentemente em jogo. Ao final, é explicado que, à luz da normatização atualmente vigente no Brasil no âmbito da saúde suplementar, ao médico assistente cabe (apenas) indicar as características dos materiais necessários, cabendo à operadora de planos de saúde a escolha da marca e do fabricante. Enquanto os magistrados não se conscientizarem dessas normas, este sério problema não se resolverá.
De escravo rico a liberto: a história do africano Manoel Joaquim Ricardo na Bahia oitocentista
Authors: Reis João José
Published: July 2016

O artigo discute a trajetória de Manoel Joaquim Ricardo, africano haussá que desembarcou na Bahia no início do século XIX como cativo e morreu em 1865 como forro e rico. Sua vida no Brasil permite perceber as possibilidades e limitações à ascensão social dos africanos sob a escravidão e em liberdade. Entre os mecanismos de mobilidade, como era de praxe na época, Ricardo investiu em escravos desde a época em que ainda era ele próprio escravo, um fenômeno raramente abordado pela historiografia. Mas também adquiriu e alugou imóveis, negociou (fez mesmo o tráfico transatlântico e interno de escravos), emprestou a juros, entre outras atividades. Outras dimensões de sua trajetória aqui abordadas são a vida familiar e religiosa, que incluiu sua rede de compadrio e suas relações com gente de candomblé. O artigo propõe o conceito de ladinização para entender a experiência de africanos como Ricardo, mesmo que não tão bem sucedidos como ele no mundo material.
Entre Christótokos e Theótokos: a construção da figura de Maria em Nestório de Constantinopla e Cirilo de Alexandria (séc. IV-V)
Authors: Campos Ludmila Caliman
Published: July 2016

O presente artigo tem como objetivo analisar a polêmica teológica que emergiu com o advento da piedade a Maria, cujo cerne do debate se resumiu à adoção, ou não, do título de Theotókos, e provocou sérios conflitos político-culturais na ekklesia, culminando com o Concílio de Éfeso (431), no qual os bispos Nestório de Constantinopla e Cirilo de Alexandria foram os protagonistas. Entretanto, nesse caso faremos especificamente um exame dos textos eclesiásticos de Nestório e a defesa de Cristótokos, além das concepções de Cirilo e a contraproposta de Theotókos para apreender a doutrina mariana vigente com o objetivo de interpretar os escritos levando em consideração as escolas teológicas às quais estavam filiados.
Gente de Guerra: novas perspectivas sobre o Brasil Holandês
Authors: Françozo Mariana
Published: July 2016

(primeiro parágrafo do texto)Na introdução a Gente de Guerra, o historiador Ronaldo Vainfas acertadamente descreve Bruno Miranda como sendo parte de uma nova geração de historiadores que, munidos do conhecimento da língua holandesa e debruçando-se sobre vasta e variada documentação primária, vem repensando e expandindo a tradicional historiografia sobre o domínio holandês no Brasil no século XVII. Neste livro, fruto de tese de doutoramento em história defendida na Universidade de Leiden em 2011, encontramos – pela primeira vez na historiografia nacional e internacional sobre o Brasil Holandês – uma obra dedicada exclusivamente à história “de alguns dos muitos personagens anônimos que participaram da conquista e manutenção do Brasil” (p.30): os soldados da Companhia das Índias Ocidentais (WIC). Cabe adicionar: personagens que participaram, também, da perda do Brasil Holandês e das derrotas da WIC na América do Sul. Afinal, como mostra Miranda, a má condição geral das tropas foi decisiva para o destino frustrado das intenções militares e políticas dos holandeses no Brasil.
Nem heróis, nem vilões: o lugar dos diretores de povoações nas dinâmicas de transgressão à lei do Diretório dos Índios (1757-1798)
Authors: Coelho Mauro Cezar , Melo Vinícius Zúniga
Published: July 2016

Este trabalho tem por objetivo melhor compreender a atuação dos diretores de povoações – agentes responsáveis pela tutela dos indígenas aldeados durante a vigência do Diretório dos Índios. Destacaremos duas questões. Primeira: o universo socioeconômico dos diretores em seus locais de trabalho, as povoações de índios. Segunda: o caráter histórico, e não moral, das transgressões cometidas por esses sujeitos. Tal objetivo se deve ao fato de considerarmos limitada a única visão formulada pela historiografia em relação aos diretores: agentes que, em razão de suas ações, foram decisivos para o fracasso do Diretório.
Understanding Innovation Engines: Automated Creativity and Improved Stochastic Optimization via Deep Learning
Authors: Nguyen A. , Yosinski J. , Clune J.
Published: July 2016

The Achilles Heel of stochastic optimization algorithms is getting trapped on local optima. Novelty Search mitigates this problem by encouraging exploration in all interesting directions by replacing the performance objective with a reward for novel behaviors. This reward for novel behaviors has traditionally required a human-crafted, behavioral distance function. While Novelty Search is a major conceptual breakthrough and outperforms traditional stochastic optimization on certain problems, it is not clear how to apply it to challenging, high-dimensional problems where specifying a useful behavioral distance function is difficult. For example, in the space of images, how do you encourage novelty to produce hawks and heroes instead of endless pixel static? Here we propose a new algorithm, the Innovation Engine, that builds on Novelty Search by replacing the human-crafted behavioral distance with a Deep Neural Network (DNN) that can recognize interesting differences between phenotypes. The key insight is that DNNs can recognize similarities and differences between phenotypes at an abstract level, wherein novelty means interesting novelty. For example, a DNN-based novelty search in the image space does not explore in the low-level pixel space, but instead creates a pressure to create new types of images (e.g., churches, mosques, obelisks, etc.). Here, we describe the long-term vision for the Innovation Engine algorithm, which involves many technical challenges that remain to be solved. We then implement a simplified version of the algorithm that enables us to explore some of the algorithm’s key motivations. Our initial results, in the domain of images, suggest that Innovation Engines could ultimately automate the production of endless streams of interesting solutions in any domain: for example, producing intelligent software, robot controllers, optimized physical components, and art.
Adapting Traditional Ideas for a New Reality: Cosmographers and Physicians Updating Astrology to Encompass the New World
Authors: Lanuza Navarro Tayra M.C.
Published: July 2016

This paper aims to demonstrate that astrology was one of the disciplines that most strongly experienced the process that led European natural philosophers, once they were confronted with the nature of the New World, to recognise that previous knowledge was not as complete or absolute as previously assumed, and that the content of several disciplines had to be renewed, both epistemologically and methodologically. This paper focuses on the work by the cosmographer Henrico Martínez, Repertorio de los tiempos (1606), in which he established the astrological influences specific to Mexico, and the work Sitio, naturaleza y propiedades de la Ciudad de Mexico (1618) by the physician Diego Cisneros, who refuted Martínez’s astrology for Mexico and created his own instructions for the use of astrology in the practice of medicine in New Spain.
A Powerful Antidote, a Strange Camel and Turkish Pepper: Iberian Science, the Discovery of the New World and the Early Modern Czech Lands
Authors: Černá Jana
Published: July 2016

This article analyses the reception of knowledge about new world nature, and, more specifically, the reception of Iberian scientific knowledge of nature in the Americas, in the early modern Czech lands. It shows how the process of the reception of information about nature in the new world differed among the urban classes, intellectuals and the nobility; particular attention is paid to herbals, cosmographical works and travel reports. On the one hand, the study reveals that the efforts of Central European intellectuals to interpret new world nature were limited by the lack of necessary data and experience, which led to some misinterpretations and simplifications. On the other hand, it shows these Central European scholars to be fully-fledged members of an information network, whose works share many of the same characteristics as Iberian and, in general, early modern European science.
Taxonomic study of the genus Cephalispa Malloch of Japan (Diptera: Muscidae)
Authors: YOSHIZAWA SATOSHI , TACHI TAKUJI
Published: July 2016

Japanese species of the genus Cephalispa Malloch, 1935 are revised. Cephalispa kudoi sp. nov., C. okinawaensis sp. nov. and C. triquetra sp. nov. are described. Lispocephala xanthogaster (Shinonaga, 2003) is transferred to the genus. A key to Japanese species is provided.
Flow Regimes over a Basin Induced by Upstream Katabatic Flows—An Idealized Modeling Study
Authors: Lehner Manuela , Rotunno Richard , Whiteman C. David
Published: July 2016

Idealized two-dimensional model simulations are performed to study the frequent nocturnal occurrence of downslope-windstorm-type flows in Arizona’s Meteor Crater. The model topography is a simplified representation of the Meteor Crater and its surroundings, with an approximately 1° mesoscale slope upstream and downstream of the crater basin. A strong surface-based inversion and a katabatic flow develop above the mesoscale slope as a result of radiational cooling. The temperature and flow profiles are evaluated against observations over low-angle slopes from two field campaigns, showing that the model’s turbulence parameterization has a strong impact on the near-surface conditions. The interaction of the katabatic flow with the basin topography leads to the formation of waves and hydraulic jumps over the basin. The simplified two-dimensional simulations show good qualitative agreement with observations of downslope-windstorm-type flows from the Meteor Crater. The sensitivity of the flow solution over the basin to basin depth, basin width, and background wind speed is investigated. The resulting flow regimes include a sweeping of the basin atmosphere, a wake over the upstream crater sidewall, waves over the basin with one or two wave crests, and a hydraulic jump. The regimes are discussed in the context of stratified flow over mountains.