bluuebunny/crossref_metadata_2025 huggingface dataset:
Are cleaning activities a source of exposure to crystalline silica in women with rheumatoid arthritis? A case–control study
Authors: Sigaux Johanna , Cavalin Catherine , Lescoat Alain , El Rharras Sarah , Macchi Odile , Brillet Pierre-Yves , Sesé Lucile , Nunes Hilario , Boissier Marie-Christophe , Rosental Paul-André , Semerano Luca
Published: August 2023

Introduction

Inhalation of crystalline silica (silicon dioxide, SiO2) is associated with a wide range of acute and chronic diseases, including rheumatoid arthritis (RA). The objectives of this work were to identify the main sources of exposure to SiO2in a series of patients with RA not selected on the basis of their professional activity, compared with a representative sample of the French general population, and to assess the association between silica exposure and disease features.

Methods

The Dust Exposure Life-Course Questionnaire (DELCQ) is a tool that enables retrospective quantification of both occupational and non-occupational lifetime exposure to SiO2. DELCQ—previously validated in a large representative sample of the French general population—was administered to 97 consecutive RA patients, and exposure scores were compared between cases and age, gender and smoking status-matched controls (1:4). The main sources of SiO2exposure were identified in cases and controls, and source-specific exposure levels were compared. The association between DELCQ scores and disease variables in cases was tested via univariable and multivariable analyses.

Results

In women with RA, the main sources of SiO2exposure were cleaning activities and dusty clothes laundry, with higher exposure levels from these sources versus the general population (p<0.005). Across the whole series of RA patients, high SiO2exposure was independently associated with mediastinal lymphadenopathy (OR 6.3, 95% CI 1.4 to 27.7).

Conclusion

Cleaning activities and dusty clothes laundry may be underestimated sources of SiO2exposure in women with RA.
Systematic literature review informing the EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis
Authors: Parodis Ioannis , Gomez Alvaro , Tsoi Alexander , Chow Jun Weng , Pezzella Denise , Girard Charlotte , Stamm Tanja A , Boström Carina
Published: August 2023

Through this systematic literature review, we assembled evidence to inform the EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). We screened articles published between January 2000 and June 2021. Studies selected for data extraction (118 for SLE and 92 for SSc) were thematically categorised by the character of their intervention. Of 208 articles included, 51 were classified as robust in critical appraisal. Physical activity was the most studied management strategy and was found to be efficacious in both diseases. Patient education and self-management also constituted widely studied topics. Many studies on SLE found psychological interventions to improve quality of life. Studies on SSc found phototherapy and laser treatment to improve cutaneous disease manifestations. In summary, non-pharmacological management of SLE and SSc encompasses a wide range of interventions, which can be combined and provided either with or without adjunct pharmacological treatment but should not aim to substitute the latter when this is deemed required. While some management strategies i.e., physical exercise and patient education, are already established in current clinical practice in several centres, others e.g., phototherapy and laser treatment, show both feasibility and efficacy, yet require testing in more rigorous trials than those hitherto conducted.
Limitations of Gold’s formula for predicting ice thickness requirements for heavy equipment
Authors: Fitzgerald Alan , Janse van Rensburg Willem
Published: August 2023

Common practice for determining the required ice thickness for vehicles and equipment relies on Gold’s formula as outlined in provincial and territorial publications relating to ice safety. This practice persists despite recent advances in ice engineering knowledge that provide more comprehensive design methods utilizing allowable stress design approaches. The authors have identified that the use of Gold’s formula for determining required ice thickness may lead to unsafe practices when utilized in the context of heavy construction equipment, increasing the risk of ice breakthrough to personnel and equipment. The authors use recent design examples to demonstrate instances in which the use of Gold’s formula results in predicted flexural tensile stresses in the ice cover that exceed the maximum design stress recommended in contemporary literature. In the case of large excavators (53 metric tonnes) and heavy dozers (40 metric tonnes), as examples, the use of Gold’s formula for determining the required ice thickness will result in predicted flexural tensile stresses that exceed the recommended maximum design stress by 56%–71%.
Transgene silencing in the moss, Physcomitrella (Physcomitrium patens)
Authors: Singer Stacy D. , Ashton Neil W.
Published: August 2023

Gene targeting is a powerful tool for functional genetic analysis. It has proved especially effective in the model plant, Physcomitrella ( Physcomitrium patens (Hedw.) Mitt.), in which integration of exogenous DNA into the genome occurs with very high efficiency at targeted positions by homologous recombination. Here, we present a preliminary characterisation of a poorly documented property of Physcomitrella targeted gene knockout lines, namely, silencing of reporter and selective marker genes of integrated targeting constructs. We discovered a high incidence of transgene silencing among Physcomitrella knockout lines and, as is the case in seed plants, cytosine (DNA) methylation of the transgenes is correlated with their silencing. Silencing in Physcomitrella is characterised by metastable epigenetic inheritance through repetitive mitosis and variable stability through meiosis.
On a new proof of the Okuyama–Sakai conjecture
Authors: Yang Di , Zhang Qingsheng
Published: August 2023

Okuyama and Sakai [JT supergravity and Brézin–Gross–Witten tau-function, J. High Energy Phys. 2020 (2020) 160] gave a conjectural equality for the higher genus generalized Brézin–Gross–Witten (BGW) free energies. In a recent work [D. Yang and Q. Zhang, On the Hodge-BGW correspondence, preprint (2021), arXiv:2112.12736], we established the Hodge-BGW correspondence on the relationship between certain special cubic Hodge integrals and the generalized BGW correlators, and a proof of the Okuyama–Sakai conjecture was also given ibid. In this paper, we give a new proof of the Okuyama–Sakai conjecture by a further application of the Dubrovin–Zhang theory for the KdV hierarchy.
Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence
Authors: Hou Min , Leng Yufang , Shi Yajing , Tan Zhiguo , Min Xiangzhen
Published: August 2023

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). Today, IBD has no successful treatment. As a result, it is of paramount importance to develop novel therapeutic agents for IBD prevention and treatment. Astragalus membranaceus (AMS) is a traditional Chinese medicine found in the AMS root. Modern pharmacological studies indicate that AMS and its constituents exhibit multiple bioactivities, such as anti-inflammatory, anti-oxidant, immune regulatory, anticancer, hypolipidemic, hypoglycemic, hepatoprotective, expectorant, and diuretic effects. AMS and its active constituents, which have been reported to be effective in IBD treatment, are believed to be viable candidate drugs for IBD treatment. These underlying mechanisms are associated with anti-inflammation, anti-oxidation, immunomodulation, intestinal epithelial repair, gut microbiota homeostasis, and improved energy metabolism. In this review, we summarize the efficacy and underlying mechanisms involved in IBD treatment with AMS and its active constituents in preclinical studies.
Deep anharmonicity on the relativistic spin-0 particles within the spherical regime
Authors: Ortakaya Sami
Published: August 2023

We present an oscillator model of relativistic spin-0 charges moving in quantum states with minimal electromagnetic field coupling. Rather than using a perturbative approach, we implemented anharmonicity directly under the integer-dependent levels. In this way, the rest mass energy is kept at 280[Formula: see text]MeV. Within the extended Pekeris approximation, we have also improved the deep approximation to the third and fourth orders near equilibrium at 7.5[Formula: see text]fm with a width range of [Formula: see text]. By taking into account the Morse potential energy, the improved approximation provides a model for the relativistic quantum states of the spatially independent rest mass without an external magnetic field. We considered an extra-energy addition that results in shifted Morse potentials in the depth range of 80–100[Formula: see text]MeV, yielding positive and negative values for particles and antiparticles, respectively. As a result of the shift, it has been concluded that the potential depth of the charged particle affects the relativistic energy levels, where we have found about 200[Formula: see text]MeV for particles and nearly [Formula: see text]10[Formula: see text]MeV for antiparticles. In addition to the negative energy states, the wave functions ([Formula: see text], [Formula: see text]) and ([Formula: see text], [Formula: see text]), which correspond to the energy levels, have been followed by the typical probability form, which shows charge distribution.
Comment on: “The structural, elastic, electronic and optical properties of MgCu under pressure: A first-principles study”
Authors: Anand K. , Rajesh K. , Sharma V. S.
Published: August 2023

Rahman et al. [International Journal of Mod. Phys. B 30, 1650199 (2016)] found that MgCu intermetallic compound with CsCl-type (B2) structure becomes unstable under pressure at about 15[Formula: see text]GPa. This prediction has been made using an elastic instability condition for second-order elastic constants given by Born. They determined the elastic constants using Hooke’s law for the linear stress–strain relationship which does not hold good at high pressures. It has been shown here that the values of elastic constants for MgCu at high pressures determined by Rahman et al. are not consistent with the values of bulk modulus computed from the Birch–Murnaghan equation of state (BM-EOS). We have used the Tallon formulation based on the thermodynamics of elastic deformation to estimate elastic constants which yields results for the bulk modulus of MgCu at different pressures in good agreement with those determined from the BM-EOS. It has been found that MgCu remains stable up to about 20 GPa which is significantly higher than the limit of elastic stability predicted by Rahman et al.
WEAK TANGENTS ON CLOSED POPCORN GRAPHS
Authors: CHEN HAIPENG , ZHENG LIXUAN
Published: August 2023

Given [Formula: see text], we study the Assouad dimension and weak tangents of closed [Formula: see text]-popcorn graphs. For all [Formula: see text], we prove that [Formula: see text] is a weak tangent of the closed [Formula: see text]-popcorn graphs by using some arguments on prime numbers. For all [Formula: see text], we first show that the Assouad dimension of the closed [Formula: see text]-popcorn graphs is 1, and then prove that [Formula: see text] is a weak tangent of them. We also discuss some specific weak tangents of closed [Formula: see text]-popcorn graphs when [Formula: see text] and [Formula: see text].
THE DEVELOPMENT OF GLOBAL PUBLIC GOODS RESEARCH: A BIBLIOMETRIC ANALYSIS
Authors: PONIKVAR NINA , VELIĆ ALAN , KEJŽAR KATJA ZAJC
Published: August 2023

Global public goods (GPGs) have been moving to the focus of discussion in international organisations due to globalisation, deepening economic integration, and technological advancements. We provide an overview of the research field of GPGs by conducting a bibliometric analysis for the period from 1993 to 2021. The increasing number of publications and citations of articles dealing with GPGs in the Web of Science is particularly noteworthy in the last decade. Publications on GPGs related to climate change experienced the largest relative growth. Analysis of the co-occurrence networks on authors’ keywords revealed that the focus of GPG research shifted between the 1993–2008 and 2009–2021 subperiods. In the latter period, our results show that sustainable development and the use of GPGs are interconnected and that the need for global governance related to GPGs is increasingly recognised in the literature. Several interrelated challenges of today’s world, related to environmental, technological, health, (cyber)security, economic, and geopolitical transformations have created the need for a new approach to GPGs.
The UK National Geological Repository: a case study in innovation
Authors: Howe Michael P. A.
Published: August 2023

The UK National Geological Repository (UKNGR) is the largest collection of British geoscience samples, with 16 m ‘specimens’, including 600 km of drillcore. Samples are available for study/subsampling by commercial organizations and researchers. Data, reports and publications must be returned. Raw data are available after 2 years.

The scientific method requires published results to be repeatable, necessitating the archiving of samples. Re-purposing samples for new research saves money and time and thereby reduces risk. The National Geological Repository (NGR) has cost over £200 bn to collect and the cost of a single deep cored borehole would be outside the funding of most research projects, so the operation of an NGR makes financial sense. Many of the boreholes have been extensively characterized, so new research can build on the wealth of published data.

The NGR has been at the forefront of international efforts to utilize digitization and the World Wide Web to improve the impact of the collections. Geographical information system (GIS) access was provided to the onshore borehole collection in 2000, and GIS access and text searching were added to the other collections over the next 10 years. This was followed by high-resolution images of the UK Continental Shelf (UKCS) cores, petrological thin-sections, and images, stereo anaglyphs and 3D-digital models of British-type fossils.
The role of core in twenty-first century reservoir characterization: an introduction
Authors: Neal Adrian , Ashton Michael , Bowman Mike , Hern Caroline Y. , Levell Bruce
Published: August 2023

The first two decades of the twenty-first century have seen significant advances across a wide range of reservoir characterization techniques, from microscale digital rock physics to macroscale 3D and 4D seismic. At the same time, industry downturns and the requirements of the energy transition have demanded improved understanding of the value and impact of subsurface data to justify their acquisition and commercial relevance. Despite changing technologies and demands, the acquisition, description and analysis of core remains a fundamental tool in managing subsurface uncertainty and associated risk. Value continues to be created in relation to the reservoir property, sedimentological, diagenetic and structural characterization of subsurface reservoirs, and these are the focus of the Core Values volume. The enduring business impact of core reflects advances in acquisition methods and laboratory-based core analysis (Theme 1 of the volume); the recent development of multi-sensor core scanning and associated artificial intelligence (AI) tools that allow unprecedented high-resolution data collection and visualization (Theme 2); the integration of core-derived data with new complementary technologies, leading to improved characterization of both cored and uncored intervals (Theme 3); the changing nature and role of legacy core collections due to digitization and improved data access (Theme 4). These are complemented by the need to better understand both existing hydrocarbon resources and other subsurface energy-related systems, particularly CCUS (carbon capture, utilization and storage), geothermal energy and the long-term storage of nuclear waste (Theme 5). Through the energy transition core will remain the ground truth foundation to any subsurface understanding and evaluation. At the same time, the technologies available to maximize the applied value of core will continue to develop and evolve, with the integration of diverse and complex core-derived and core-related datasets becoming the norm. Even in the face of AI's impact and value in handling such datasets, those earth scientists who can effectively analyse, interpret and integrate core will still be best placed to meet the subsurface challenges of the future.
Low-Resource Language Information Processing using Dwarf Mongoose Optimization with Deep Learning Based Sentiment Classification
Authors: Gupta Indresh Kumar , Rana Khudhair Abbas Ahmed , Gaur Vimal , Sagar Kalpna , Sharma D.P. , Alkhayyat Ahmed
Published: August 2023

Asian and low-resource language information processing refers to the field of computational linguistics that aims to develop natural language processing (NLP) technologies for languages that have fewer available language resources or are less commonly spoken. This is an important field of study because many languages in Asia and other parts of the world are underrepresented in the field of NLP, which may limit access to information and technology for speakers of these languages. The growing volume of user-generated content on the web has made sentiment analysis (SA) a significant tool for extracting data regarding human emotional states. Twitter sentiment detectors provide a superior solution for assessing the quality of products and services compared to other conventional technologies. The detection performance and classifier accuracy of SA, which can be highly dependent on classifier methods and the quality of input features have been utilised. Deep learning (DL) methods use distinct techniques to extract data from raw data such as tweets or texts and represent them in different forms of models. Therefore, this article presents a Dwarf Mongoose Optimization with Deep Learning-Based Twitter Sentiment Classification (DMODL-TSC) technique to classify sentiments based on tweets. The presented DMODL-TSC technique leverages the concepts of natural language processing (NLP) and DL. Primarily, the raw tweets are preprocessed to transform them into a useful format. Next, the DMODL-TSC technique uses the advanced FastText word embedding technique. Moreover, the bidirectional recurrent neural network (BiRNN) method is utilized for the recognition of sentiments. Finally, the DMO technique is utilized for the optimal hyperparameter optimization of the BiRNN method, which leads to effective classification performance. The comprehensive result examination of the DMODL-TSC system was tested on three datasets, and the obtained outcomes illustrate the supremacy of the DMODL-TSC approach.
A Model Checker for Operator Precedence Languages
Authors: Chiari Michele , Mandrioli Dino , Pontiggia Francesco , Pradella Matteo
Published: August 2023

The problem of extending model checking from finite state machines to procedural programs has fostered much research toward the definition of temporal logics for reasoning on context-free structures. The most notable of such results are temporal logics on Nested Words, such as CaRet and NWTL. Recently, Precedence Oriented Temporal Logic (POTL) has been introduced to specify and prove properties of programs coded trough an Operator Precedence Language (OPL). POTL is complete w.r.t. the FO restriction of the MSO logic previously defined as a logic fully equivalent to OPL. POTL increases NWTL’s expressive power in a perfectly parallel way as OPLs are more powerful that nested words.

In this article, we produce a model checker, named POMC, for OPL programs to prove properties expressed in POTL. To the best of our knowledge, POMC is the first implemented and openly available model checker for proving tree-structured properties of recursive procedural programs. We also report on the experimental evaluation we performed on POMC on a nontrivial benchmark.
Filesystem Fragmentation on Modern Storage Systems
Authors: Park Jonggyu , Eom Young Ik
Published: August 2023

Filesystem fragmentation has been one of the primary reasons for computer systems to get slower over time. However, there have been rapid changes in modern storage systems over the past decades, and modern storage devices such as solid state drives have different mechanisms to access data, compared with traditional rotational ones. In this article, we revisit filesystem fragmentation on modern computer systems from both performance and fairness perspectives. According to our extensive experiments, filesystem fragmentation not only degrades I/O performance of modern storage devices, but also incurs various problems related to I/O fairness, such as performance interference. Unfortunately, conventional defragmentation tools are designed primarily for hard disk drives and thus generate an unnecessarily large amount of I/Os for data migration. To mitigate such problems, this article present FragPicker, a new defragmentation tool for modern storage devices. FragPicker analyzes the I/O behaviors of each target application and defragments only necessary pieces of data whose migration can contribute to performance improvement, thereby effectively minimizing the I/O amount for defragmentation. Our evaluation with YCSB workload-C shows FragPicker reduces the total amount of I/O for defragmentation by around 66% and the elapsed time by around 84%, while showing a similar level of defragmentation effect.
The Coordination of Titanium Ions and the Electrocrystallization Mechanism in Molten Chloride-Fluoride Salts
Authors: Kong Ruijing , Liu Shanshan , Lv Zepeng , Li Shaolong , Fan Yong , He Jilin , Jiao Handong , Song Jianxun
Published: August 2023

In electrochemical process, electrolyte composition is one of the key factors that determine the electrochemical behavior of elements. In this work, the nucleation mechanism and deposition process of titanium ions after the introduction of fluoride ions into molten salt were analyzed in detail by electrochemical technology, and the coordination behavior between fluorine ions and titanium was explored by molecular dynamics simulation, revealing the relationship between the electrocrystallization mechanism of titanium and its coordination properties. It can be found that the electrocrystallization mechanism of titanium ions is related to its coordination structure. Under our experimental conditions, the Ti-Cl bond in the system was gradually replaced by the Ti-F bond. This will lead to the change of charge transfer and ion diffusion of titanium ions, which will have an important effect on the electrocrystallization processes. This work has an important guiding significance for further study on the influence of different molten salt systems on the electrocrystallization mechanism of molten salt electrolytic titanium.
Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation
Authors: Sun Qian , Weng Rui-Xia , Li Jia-Hui , Li Yong-Chang , Xu Ji-Tian , Li Rui , Lu Xiaomin , Xu Guang-Yin
Published: August 2023

This work demonstrated that the expression of Rab27a in the anterior cingulate cortex was upregulated, which mediated multivesicular bodies trafficking to the plasma membrane and led to the increased release of neuronal exosomes, thus contributing to colorectal visceral pain in neonatal maternal deprivation (NMD) mice. Blocking the release of exosomes or downregulation of Rab27a could alleviate colorectal visceral pain in NMD mice. These data may provide a promising strategy for the treatment of visceral pain in irritable bowel syndrome patients.
An Australian National Survey of First Nations Careers in Health Services
Authors: Nathan S. , Meyer L. , Joseph T. , Blignault I. , Bailey J. , Demasi K. , Newman J. , Briggs N. , Williams M. , Lew Fatt E.
Published: August 2023

A strong First Nations health workforce is necessary to meet community needs, health rights, and health equity. This paper reports the findings from a national survey of Australia’s First Nations people employed in health services to identify enablers and barriers to career development, including variations by geographic location and organisation type. A cross-sectional online survey was undertaken across professions, roles, and jurisdictions. The survey was developed collaboratively by Aboriginal and non-Aboriginal academics and Aboriginal leaders. To recruit participants, the survey was promoted by key professional organisations, First Nations peak bodies and affiliates, and national forums. In addition to descriptive statistics, logistic regression was used to identify predictors of satisfaction with career development and whether this varied by geographic location or organisation type. Of the 332 participants currently employed in health services, 50% worked in regional and remote areas and 15% in Aboriginal Community-Controlled Health Organisations (ACCHOs) with the remainder in government and private health services. All enablers identified were associated with satisfaction with career development and did not vary by location or organisation type. “Racism from colleagues” and “lack of cultural awareness,” “not feeling supported by their manager,” “not having role models or mentors,” and “inflexible human resource policies” predicted lower satisfaction with career development only for those employed in government/other services. First Nations people leading career development were strongly supported. The implications for all workplaces are that offering even a few career development opportunities, together with supporting leadership by Aboriginal and Torres Strait Islander staff, can make a major difference to satisfaction and retention. Concurrently, attention should be given to building managerial cultural capabilities and skills in supporting First Nations’ staff career development, building cultural safety, providing formal mentors and addressing discriminatory and inflexible human resources policies.
Mechanical Interlocking Approaches to the Prediction of Mechanical and Tribological Behavior of Natural Fiber-Reinforced Polymer Hybrid Nanocomposites or Automotive Applications
Authors: Venkatesh R. , Santhosh Kumar P. C. , Senthilkumar A. , Krishna J. Phani , Chandramohan P. , Aneesh V. N. , Malladi Avinash , Priya C. B. , Ramaraj Elangomathavan
Published: August 2023

Polymer matrix composites synthesized with biodegradable natural fiber obtain a predominant structure with specific properties at a low-processing cost. The unique characteristics of polymer matrix composites were magnetized in automotive parts like top roof, panel, and seat frame applications. American Society for Testing and Materials (ASTM) G99 analyzed the wear characteristics of synthesized composites through a pin-on-disc wear tester with an EN32 steel disc. The epoxy hybrid composites have been synthesized via a conventional casting process assisted with a mechanical interlock technique to obtain a predominant structure with specific properties at a low-processing cost. The advanced composite contained different jute weights (50, 25, 50, and 75 g) and coconut coir (50, 70, 45, and 20 g) hybridized with graphite particles. ASTM D2240, D638, and D790 standards evaluated the fabricated composite hardness, tensile, and flexural strength. The Sample 4 hybrid composite found maximum hardness, tensile, and flexural strength of 27.41 ± 0.99 Hv, 51.69 ± 1.01MPa, and 55.94 ± 0.78 MPa, respectively. Sample 4 offered good wear resistance of their volumetric wear rate of 0.043 cm3 on 40 N average load at 0.25 m/s sliding speed. It is increased by 12% compared to Sample 1 at 40 N applied load on 2.5 m/s sliding speed.
New Characterizations and Representations of the Bott–Duffin Inverse
Authors: Wu Jiabao , Zuo Kezheng , Cvetković-Ilić Dragana S. , Zou Honglin
Published: August 2023

The paper focuses on the class of the Bott–Duffin inverses. Several original features of the class are identified and new properties are characterized. Some of the results available in the literature are recaptured in a more general form. BD matrices are also introduced and some properties are given.
Supplementary Table S3 from Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood
Authors: Kehm Rebecca D. , Lilge Lothar , Walter E. Jane , White Melissa , Herbstman Julie B. , Perera Frederica P. , Miller Rachel L. , Terry Mary Beth , Tehranifar Parisa
Published: August 2023

Supplementary Table S3 shows the characteristics of adult women by maternal education at birth in the Columbia Breast Cancer and the Environment Research Program (Columbia-BCERP) Study, n = 160.
Supplementary Figure S3 from Characteristics of Cancer Epidemiology Studies That Employ Metabolomics: A Scoping Review
Authors: Yu Catherine T. , Farhat Zeinab , Livinski Alicia A. , Loftfield Erikka , Zanetti Krista A.
Published: August 2023

Supplementary Figure S3 shows bar graph displaying the distribution of metabolomic epidemiology studies of cancer reporting race information by race category.
Supplementary Figure S1 from Characteristics of Cancer Epidemiology Studies That Employ Metabolomics: A Scoping Review
Authors: Yu Catherine T. , Farhat Zeinab , Livinski Alicia A. , Loftfield Erikka , Zanetti Krista A.
Published: August 2023

Supplementary Figure S1 shows metabolomic epidemiology studies of cancer published from January 1998 to June 2021.
Supplementary Table 4 from Body Composition, Relative Dose Intensity, and Adverse Events among Patients with Colon Cancer
Authors: Cheng En , Caan Bette J. , Cawthon Peggy M. , Evans William J. , Hellerstein Marc K. , Shankaran Mahalakshmi , Nyangau Edna , Campbell Kristin L. , Lee Catherine , Binder Alexandra M. , Meyerhardt Jeffrey A. , Schmitz Kathryn H. , Cespedes Feliciano Elizabeth M.
Published: August 2023

Supplementary Table 4. The Adjusted Associations of Body Composition Measurements (Per SD Increase) with Reduced RDI Counting for Each Chemotherapy Agent
Data from Body Composition, Relative Dose Intensity, and Adverse Events among Patients with Colon Cancer
Authors: Cheng En , Caan Bette J. , Cawthon Peggy M. , Evans William J. , Hellerstein Marc K. , Shankaran Mahalakshmi , Nyangau Edna , Campbell Kristin L. , Lee Catherine , Binder Alexandra M. , Meyerhardt Jeffrey A. , Schmitz Kathryn H. , Cespedes Feliciano Elizabeth M.
Published: August 2023

AbstractBackground:
Despite evidence that low muscle increases the risk of chemotoxicity, most chemotherapies are dosed on body surface area without considering body composition. Among 178 patients with colon cancer, we assessed muscle and adipose tissue with multiple techniques and examined their associations with relative dose intensity (RDI) and adverse events.
Methods:
We estimated (i) cross-sectional skeletal muscle area (SMA) and total adipose tissue (TAT) area at L3 from computed tomography (CT); (ii) appendicular lean mass (ALM) and total body fat (TBF) mass from dual-energy X-ray absorptiometry (DXA); and (iii) total body skeletal muscle mass using D3-creatine (D3Cr) dilution. We standardized each measurement by its sex-specific standard deviation (SD). The primary outcome was reduced RDI (RDI <85%). The secondary outcome was the number of moderate and severe adverse events during each cycle of chemotherapy. We estimated the associations of muscle and adipose tissue measurements (per SD increase) with reduced RDI using logistic regression and adverse events using generalized estimating equations for repeated measures.
Results:
Higher CT SMA and DXA ALM were significantly associated with a lower risk of reduced RDI [odds ratios: 0.56 (0.38–0.81) for CT SMA; 0.56 (0.37–0.84) for DXA ALM]. No measurements of muscle or adipose tissue were associated with adverse events.
Conclusions:
More muscle was associated with improved chemotherapy completion among patients with colon cancer, whereas muscle and adipose tissue were not associated with adverse events.
Impact:
Considering body composition may help personalize dosing for colon cancer chemotherapy by identifying patients at risk for poor chemotherapy outcomes.
Data from Risk of Colorectal Cancer and Colorectal Cancer Mortality Beginning One Year after a Negative Fecal Occult Blood Test, among Screen-Eligible 76- to 85-Year-Olds
Authors: Dalmat Ronit R. , Ziebell Rebecca A. , Kamineni Aruna , Phipps Amanda I. , Weiss Noel S. , Breslau Erica S. , Burnett-Hartman Andrea N. , Corley Douglas A. , Doria-Rose V. Paul , Green Beverly B. , Halm Ethan A. , Levin Theodore R. , Schottinger Joanne E. , Chubak Jessica
Published: August 2023

AbstractBackground:
Colorectal cancer screening is universally recommended for adults ages 45 to 75 years. Noninvasive fecal occult blood tests are effective screening tests recommended by guidelines. However, empirical evidence to inform older adults’ decisions about whether to continue screening is sparse, especially for individuals with prior screening.
Methods:
This study used a retrospective cohort of older adults at three Kaiser Permanente integrated healthcare systems (Northern California, Southern California, Washington) and Parkland Health. Beginning 1 year following a negative stool-based screening test, cumulative risks of colorectal cancer incidence, colorectal cancer mortality (accounting for deaths from other causes), and non-colorectal cancer mortality were estimated.
Results:
Cumulative incidence of colorectal cancer in screen-eligible adults ages 76 to 85 with a negative fecal occult blood test 1 year ago (N = 118,269) was 0.23% [95% confidence interval (CI), 0.20%–0.26%] after 2 years and 1.21% (95% CI, 1.13%–1.30%) after 8 years. Cumulative colorectal cancer mortality was 0.03% (95% CI, 0.02%–0.04%) after 2 years and 0.33% (95% CI, 0.28%–0.39%) after 8 years. Cumulative risk of death from non-colorectal cancer causes was 4.81% (95% CI, 4.68%–4.96%) after 2 years and 28.40% (95% CI, 27.95%–28.85%) after 8 years.
Conclusion:
Among 76- to 85-year-olds with a recent negative stool-based test, cumulative colorectal cancer incidence and mortality estimates were low, especially within 2 years; death from other causes was over 100 times more likely than death from colorectal cancer.
Impact:
These findings of low absolute colorectal cancer risk, and comparatively higher risk of death from other causes, can inform decision-making regarding whether and when to continue colorectal cancer screening beyond age 75 among screen-eligible adults.
Data from Patterns of Evidence-Based Care for the Diagnosis, Staging, and First-line Treatment of Breast Cancer by Race–Ethnicity: A SEER-Medicare Study
Authors: Herbach Emma L. , Nash Sarah H. , Lizarraga Ingrid M. , Carnahan Ryan M. , Wang Kai , Ogilvie Amy C. , Curran Michaela , Charlton Mary E.
Published: August 2023

AbstractBackground:
Racial and ethnic disparities in guideline-recommended breast cancer treatment are well documented, however studies including diagnostic and staging procedures necessary to determine treatment indications are lacking. The purpose of this study was to characterize patterns in delivery of evidence-based services for the diagnosis, clinical workup, and first-line treatment of breast cancer by race–ethnicity.
Methods:
SEER-Medicare data were used to identify women diagnosed with invasive breast cancer between 2000 and 2017 at age 66 or older (n = 2,15,605). Evidence-based services included diagnostic procedures (diagnostic mammography and breast biopsy), clinical workup (stage and grade determination, lymph node biopsy, and HR and HER2 status determination), and treatment initiation (surgery, radiation, chemotherapy, hormone therapy, and HER2-targeted therapy). Poisson regression was used to estimate rate ratios (RR) and 95% confidence intervals (CI) for each service.
Results:
Black and American Indian/Alaska Native (AIAN) women had significantly lower rates of evidence-based care across the continuum from diagnostics through first-line treatment compared to non-Hispanic White (NHW) women. AIAN women had the lowest rates of HER2-targeted therapy and hormone therapy initiation. While Black women also had lower initiation of HER2-targeted therapy than NHW, differences in hormone therapy were not observed.
Conclusions:
Our findings suggest patterns along the continuum of care from diagnostic procedures to treatment initiation may differ across race–ethnicity groups.
Impact:
Efforts to improve delivery of guideline-concordant treatment and mitigate racial–ethnic disparities in healthcare and survival should include procedures performed as part of the diagnosis, clinical workup, and staging processes.
Dietary Fish and n-3 Polyunsaturated Fatty Acid Consumption, and Renal Cell Carcinoma Risk in Japan: The Japan Public Health Center-Based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: August 2023

Background:

Previous epidemiologic studies found inconsistent associations between fish consumption and renal cell carcinoma (RCC). Although the consumption of n-3 polyunsaturated fatty acids (PUFA) was reported to protect against the development of some types of cancer, little is known regarding its association with RCC.

Methods:

We investigated the association between fish and n-3 PUFA consumption and RCC risk using the Japan Public Health Center-based Prospective Study. We examined data from 84,063 eligible Japanese participants aged 45 to 74 years who responded to a validated food frequency questionnaire for Cohort I in 1995 and Cohort II in 1998. The participants were followed-up until 2013. HRs and 95% confidence intervals (CI) were estimated using a multivariable-adjusted Cox proportional hazard model, and the exposure level was categorized into quartiles.

Results:

Among the 1,272,298 person-years of follow-up, 262 cases of newly diagnosed RCC were identified. The multivariate-adjusted HRs for the highest vs. lowest quartile of fish, including shellfish, were (HR = 1.43; 95% CI, 0.98–2.07) and the individual marine n-3 PUFAs were (HR = 1.56; 95% CI, 1.07–2.28; Ptrend = 0.09) for eicosapentenoic acid, (HR = 1.81; 95% CI, 1.27–2.59; Ptrend = 0.01) for docosapentaenoic acid, and (HR = 1.56; 95% CI, 1.07–2.27; Ptrend = 0.09) for docosahexaenoic acid. RCC were further categorized on the basis of diagnosis methods and cancer stage, and the positive correlation did not change substantially.

Conclusions:

We demonstrated that high consumption of n-3 PUFA is associated with RCC risk.

Impact:

The positive association between n-3 PUFA and RCC risk was observed in Japanese who consume higher amounts of fish than Western populations.
Supplementary Table S4 from A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis
Authors: Mascarenhas John , Migliaccio Anna Rita , Kosiorek Heidi , Bhave Rupali , Palmer Jeanne , Kuykendall Andrew , Mesa Ruben , Rampal Raajit K. , Gerds Aaron T. , Yacoub Abdulraheem , Pettit Kristen , Talpaz Moshe , Komrokji Rami , Kremyanskaya Marina , Gonzalez Agapito , Fabris Frank , Johnson Kathryn , Dougherty Mikaela , McGovern Erin , Arango Ossa Juan , Domenico Dylan , Farnoud Noushin , Weinberg Rona Singer , Kong Amy , Najfeld Vesna , Vannucchi Alessandro Maria , Arciprete Francesca , Zingariello Maria , Falchi Mario , Salama Mohamed E. , Mead-Harvey Carolyn , Dueck Amylou , Varricchio Lilian , Hoffman Ronald
Published: August 2023

Individual patient data for AUC, Cmax and Tmax for dose levels 1 and 2 (lot A). Summary measures for DL 1 and DL2 are shown in red.
Figure S1 from Randomized Phase II Trial of Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance after Upfront Autologous Hematopoietic Cell Transplantation for Multiple Myeloma: BMT CTN 1401
Authors: Chung David J. , Shah Nina , Wu Juan , Logan Brent , Bisharat Lina , Callander Natalie , Cheloni Giulia , Anderson Kenneth , Chodon Thinle , Dhakal Binod , Devine Steve , Somaiya Dutt Poorvi , Efebera Yvonne , Geller Nancy , Ghiasuddin Haider , Hematti Peiman , Holmberg Leona , Howard Alan , Johnson Bryon , Karagkouni Dimitra , Lazarus Hillard M. , Malek Ehsan , McCarthy Philip , McKenna David , Mendizabal Adam , Nooka Ajay , Munshi Nikhil , O'Donnell Lynn , Rapoport Aaron P. , Reese Jane , Rosenblatt Jacalyn , Soiffer Robert , Stroopinsky Dina , Uhl Lynne , Vlachos Ioannis S. , Waller Edmund K. , Young James W. , Pasquini Marcelo C. , Avigan David
Published: August 2023

Supplemental Figure 1: (A) Progression Free Survival Kaplan Meier Curve. (B) Overall Survival Kaplan Meier Curve.
Supplementary Figure S4 from A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis
Authors: Mascarenhas John , Migliaccio Anna Rita , Kosiorek Heidi , Bhave Rupali , Palmer Jeanne , Kuykendall Andrew , Mesa Ruben , Rampal Raajit K. , Gerds Aaron T. , Yacoub Abdulraheem , Pettit Kristen , Talpaz Moshe , Komrokji Rami , Kremyanskaya Marina , Gonzalez Agapito , Fabris Frank , Johnson Kathryn , Dougherty Mikaela , McGovern Erin , Arango Ossa Juan , Domenico Dylan , Farnoud Noushin , Weinberg Rona Singer , Kong Amy , Najfeld Vesna , Vannucchi Alessandro Maria , Arciprete Francesca , Zingariello Maria , Falchi Mario , Salama Mohamed E. , Mead-Harvey Carolyn , Dueck Amylou , Varricchio Lilian , Hoffman Ronald
Published: August 2023

Oncoprint Analysis of Serial Samples from Phase 1b Trial of AVID200
Supplementary Figure S3 from A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis
Authors: Mascarenhas John , Migliaccio Anna Rita , Kosiorek Heidi , Bhave Rupali , Palmer Jeanne , Kuykendall Andrew , Mesa Ruben , Rampal Raajit K. , Gerds Aaron T. , Yacoub Abdulraheem , Pettit Kristen , Talpaz Moshe , Komrokji Rami , Kremyanskaya Marina , Gonzalez Agapito , Fabris Frank , Johnson Kathryn , Dougherty Mikaela , McGovern Erin , Arango Ossa Juan , Domenico Dylan , Farnoud Noushin , Weinberg Rona Singer , Kong Amy , Najfeld Vesna , Vannucchi Alessandro Maria , Arciprete Francesca , Zingariello Maria , Falchi Mario , Salama Mohamed E. , Mead-Harvey Carolyn , Dueck Amylou , Varricchio Lilian , Hoffman Ronald
Published: August 2023

Duration of treatment and response status.
Data from Randomized Trial of a Personalized Dendritic Cell Vaccine after Autologous Stem Cell Transplant for Multiple Myeloma
Authors: Chung David J. , Shah Nina , Wu Juan , Logan Brent , Bisharat Lina , Callander Natalie , Cheloni Giulia , Anderson Kenneth , Chodon Thinle , Dhakal Binod , Devine Steven , Somaiya Dutt Poorvi , Efebera Yvonne , Geller Nancy , Ghiasuddin Haider , Hematti Peiman , Holmberg Leona , Howard Alan , Johnson Bryon , Karagkouni Dimitra , Lazarus Hillard M. , Malek Ehsan , McCarthy Philip , McKenna David , Mendizabal Adam , Nooka Ajay , Munshi Nikhil , O'Donnell Lynn , Rapoport Aaron P. , Reese Jane , Rosenblatt Jacalyn , Soiffer Robert , Stroopinsky Dina , Uhl Lynne , Vlachos Ioannis S. , Waller Edmund K. , Young James W. , Pasquini Marcelo C. , Avigan David
Published: August 2023

Abstract
Purpose: Vaccination with dendritic cell (DC)/multiple myeloma (MM) fusions has been shown to induce the expansion of circulating MM-reactive lymphocytes and consolidation of clinical response following autologous hematopoietic cell transplant (autoHCT). Patients and Methods: In this randomized phase II trial (NCT02728102), we assessed the effect of DC/MM fusion vaccination, GM-CSF, and lenalidomide maintenance as compared to control arms of GM-CSF and lenalidomide or lenalidomide maintenance alone on clinical response rates and induction of MM-specific immunity at 1-year post-transplant. Results: The study enrolled 203 patients, with 140 randomized post-transplantation. Vaccine production was successful in 63/68 patients. At 1 year, rates of CR were 52.9% (vaccine) and 50% (control) (p=0.37, 80% CI 44.5%, 61.3% and 41.6%, 58.4%, respectively), and rates of VGPR or better were 85.3% (vaccine) and 77.8% (control) (p=0.2). Conversion to CR at 1 year was 34.8% (vaccine) and 27.3% (control) (p=0.4). Vaccination induced a statistically significant expansion of MM-reactive T cells at 1 year as compared to prior to vaccination (p=0.024) and in contrast to the non-vaccine arm (p=0.026). Single-cell transcriptomics revealed clonotypic expansion of activated CD8 cells and shared dominant clonotypes between patients at 1-year post-transplant. Conclusions: DC/MM fusion vaccination with lenalidomide did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating MM-reactive lymphocytes indicative of tumor-specific immunity. Site-specific production of a personalized cell therapy with centralized product characterization was effectively accomplished in the context of a multicenter cooperative group study.
Data from A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis
Authors: Mascarenhas John , Migliaccio Anna Rita , Kosiorek Heidi , Bhave Rupali , Palmer Jeanne , Kuykendall Andrew , Mesa Ruben , Rampal Raajit K. , Gerds Aaron T. , Yacoub Abdulraheem , Pettit Kristen , Talpaz Moshe , Komrokji Rami , Kremyanskaya Marina , Gonzalez Agapito , Fabris Frank , Johnson Kathryn , Dougherty Mikaela , McGovern Erin , Arango Ossa Juan , Domenico Dylan , Farnoud Noushin , Weinberg Rona Singer , Kong Amy , Najfeld Vesna , Vannucchi Alessandro Maria , Arciprete Francesca , Zingariello Maria , Falchi Mario , Salama Mohamed E. , Mead-Harvey Carolyn , Dueck Amylou , Varricchio Lilian , Hoffman Ronald
Published: August 2023

AbstractPurpose:
Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by systemic symptoms, cytopenias, organomegaly, and bone marrow fibrosis. JAK2 inhibitors afford symptom and spleen burden reduction but do not alter the disease course and frequently lead to thrombocytopenia. TGFβ, a pleiotropic cytokine elaborated by the MF clone, negatively regulates normal hematopoiesis, downregulates antitumor immunity, and promotes bone marrow fibrosis. Our group previously showed that AVID200, a potent and selective TGFβ 1/3 trap, reduced TGFβ1-induced proliferation of human mesenchymal stromal cells, phosphorylation of SMAD2, and collagen expression. Moreover, treatment of MF mononuclear cells with AVID200 led to increased numbers of progenitor cells (PC) with wild-type JAK2 rather than JAK2V617F.
Methods and Patients:
We conducted an investigator-initiated, multicenter, phase Ib trial of AVID200 monotherapy in 21 patients with advanced MF.
Results:
No dose-limiting toxicity was identified at the three dose levels tested, and grade 3/4 anemia and thrombocytopenia occurred in 28.6% and 19.0% of treated patients, respectively. After six cycles of therapy, two patients attained a clinical benefit by IWG-MRT criteria. Spleen and symptom benefits were observed across treatment cycles. Unlike other MF-directed therapies, increases in platelet counts were noted in 81% of treated patients with three patients achieving normalization. Treatment with AVID200 resulted in potent suppression of plasma TGFβ1 levels and pSMAD2 in MF cells.
Conclusions:
AVID200 is a well-tolerated, rational, therapeutic agent for the treatment of patients with MF and should be evaluated further in patients with thrombocytopenic MF in combination with agents that target aberrant MF intracellular signaling pathways.
Supplementary Table and Figure Legends from Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects
Authors: Landa Iñigo , Thornton Caitlin E.M. , Xu Bin , Haase Jacob , Krishnamoorthy Gnana P. , Hao Jingzhu , Knauf Jeffrey A. , Herbert Zachary T. , Martínez Paula , Blasco María A. , Ghossein Ronald , Fagin James A.
Published: August 2023

Supplementary TableS 1-7 and Figure Legends 1-5