bluuebunny/crossref_metadata_2025 huggingface dataset:
CD317/Tetherin is an organiser of membrane microdomains
Authors: Billcliff Peter G. , Rollason Ruth , Prior Ian , Owen Dylan M. , Gaus Katharina , Banting George
Published: February 2013

The integral membrane protein tetherin has been associated with an eclectic mix of cellular processes, including restricting the release of a range of enveloped viruses from infected cells. The unusual topology of tetherin (it possesses both a conventional transmembrane domain and a glycosylphosphatidylinositol anchor), its localisation to membrane microdomains/lipid rafts and the fact that its cytosolic domain can be linked (indirectly) to the actin cytoskeleton, led us to speculate that tetherin might form a ‘tethered picket fence’ and thereby play a role in the organisation of lipid rafts. We now show that knocking down expression of tetherin leads to changes in the distribution of lipid raft-localised proteins and changes in the organisation of lipids in the plasma membrane. These changes can be reversed by re-expression of wild type tetherin, but not by any of a range of tetherin-based constructs, indicating that no individual feature of the tetherin sequence is dispensable in the context of its lipid raft organising function.
One-Pot Synthesis and Evaluation of Properties of Optically Active Poly(imide–urethane)s
Authors: Toiserkani Hojjat , Rafiaee Marziyeh
Published: February 2013

A new diacylazide 2 bearing two preformed imide rings and (S)-valine was prepared in three steps, starting from the reaction of 4,4′-carbonyldiphthalic anhydride with (S)-valine in refluxing glacial acetic acid, followed by treating 4,4′-carbonylbis[(S)-2′′-phthalimidovaline] (1) with ethyl chloroformate in the presence of triethylamine, and subsequently by a nucleophilic reaction with sodium azide. A novel family of optically active poly(imide–urethane)s (PIUs) with moderate inherent viscosities in the range 0.25–0.44 dL g−1 were prepared from diacylazide 2 and various aromatic diols in dry toluene under refluxing in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO, triethylenediamine) as a catalyst. The polycondensation reaction readily proceeded in desirable yields as one-pot reactions starting from 2 without separate synthesis of the corresponding diisocyanate. All of the resulting polymers were thoroughly characterized by spectroscopic methods and specific rotation. The PIUs exhibited an excellent solubility in a variety of polar solvents. Experimental results indicated that all the PIUs had glass-transition temperature between 179 and 218 °C, the decomposition temperature at 10% weight loss between 201 and 223 °C under nitrogen.
Titration Analysis of Electron Storage and Discharge Properties of Carbon Nanodots
Authors: Matsuoka Ken-ichi , Shibuya Ryo , Fujita Katsuhiko
Published: February 2013

Sequential electron-transfer experiments involving carbon nanodots (CNDs) by a titration method revealed the electron storage and discharge properties of CNDs. The CND accepts electrons from the methyl viologen radical and discharges them to redox species having appropriate reduction potentials. We succeeded in estimating the upper-limit reduction potential of the stored electrons in CNDs.
Heterocyclic Carbene–Metal-catalyzed Csp2–Csp2 and Csp–Csp2 Couplings Using Nonmetallic Substrates
Authors: Yus Miguel , Pastor Isidro M
Published: February 2013

The use of carbene ligands for transition-metal complexes has been developed in the last decades, being of special interest those carbenes derived from a nitrogen-containing heterocyclic system. An interesting variety of carbene–metal complexes has been tested in the Mizoroki–Heck reaction. In comparison, few examples can be found for the Matsuda–Heck version of this coupling reaction. Additionally, the Sonogashira coupling has been also catalyzed with different carbene–metal catalysts.
Social Ties and User-Generated Content: Evidence from an Online Social Network
Authors: Shriver Scott K. , Nair Harikesh S. , Hofstetter Reto
Published: February 2013

We exploit changes in wind speeds at surfing locations in Switzerland as a source of variation in users' propensity to post content about their surfing activity on an online social network. We exploit this variation to test whether users' online content-generation activity is codetermined with their social ties. Economically significant effects of this type can produce positive feedback that generates local network effects in content generation. When quantitatively significant, the increased content and tie density arising from the network effect induces more visitation and browsing on the site, which fuels growth by generating advertising revenue. We find evidence consistent with such network effects.

This paper was accepted by J. Miguel Villas-Boas, marketing.
Inferring Reporting-Related Biases in Hedge Fund Databases from Hedge Fund Equity Holdings
Authors: Agarwal Vikas , Fos Vyacheslav , Jiang Wei
Published: February 2013

This paper formally analyzes the biases related to self-reporting in hedge fund databases by matching the quarterly equity holdings of a complete list of 13F-filing hedge fund companies to the union of five major commercial databases of self-reporting hedge funds between 1980 and 2008. We find that funds initiate self-reporting after positive abnormal returns that do not persist into the reporting period. Termination of self-reporting is followed by both return deterioration and outflows from the funds. The propensity to self-report is consistent with the trade-offs between the benefits (e.g., access to prospective investors) and costs (e.g., partial loss of trading secrecy and flexibility in selective marketing). Finally, returns of self-reporting funds are higher than that of nonreporting funds using characteristic-based benchmarks. However, the difference is not significant using alternative choices of performance measures.

This paper was accepted by Brad Barber, finance.
Social Networks, Information Acquisition, and Asset Prices
Authors: Han Bing , Yang Liyan
Published: February 2013

We analyze a rational expectations equilibrium model to explore the implications of information networks for the financial market. When information is exogenous, social communication improves market efficiency. However, social communication crowds out information production due to traders' incentives to “free ride” on informed friends and on a more informative price system. Overall, social communication hurts market efficiency when information is endogenous. The network effects on the cost of capital, liquidity, trading volume, and welfare are also sensitive to whether information is endogenous. Our analysis highlights the importance of information acquisition in examining the implications of information networks for financial markets.

This paper was accepted by Wei Xiong, finance.
Adverse Events Associated with Procedural Sedation in Pediatric Patients in the Emergency Department
Authors: Cudny Magdalena E. , Wang N. Ewen , Bardas Sandra L. , Nguyen Carolyn N.
Published: February 2013

Purpose

To determine the agents used by emergency medicine (EM) physicians in pediatric procedural sedation and the associated adverse events (AEs) and to provide recommendations for optimizing drug therapy in pediatric patients.

Methods

We conducted a prospective study at Stanford Hospital's pediatric emergency department (ED) from April 2007 to April 2008 to determine the medications most frequently used in pediatric procedural sedation as well as their effectiveness and AEs. Patients, 18 years old or younger, who required procedural sedation in the pediatric ED were eligible for the study. The data collected included medical record number, sex, age, height, weight, procedure type and length, physician, and agents used. For each agent, the dose, route, time from administration to onset of sedation, duration of sedation, AEs, and sedation score were recorded. Use of supplemental oxygen and interventions during procedural sedation were also recorded.

Results

We found that in a convenience sample of 196 children (202 procedures) receiving procedural sedation in a university-based ED, 8 different medications were used (ketamine, etomidate, fentanyl, hydromorphone, methohexital, midazolam, pentobarbital, and thiopental). Ketamine was the most frequently used medication (88%), regardless of the procedure. Only twice in the study was the medication that was initially used for procedural sedation changed completely. Fracture reduction was the most frequently performed procedure (41%), followed by laceration/suture repair (32%). There were no serious AEs reported.

Conclusion

EM-trained physicians can safely perform pediatric procedural sedation in the ED. In the pediatric ED, the most common procedure requiring conscious sedation is fracture reduction, with ketamine as the preferred agent.
Linaclotide
Authors: Cada Dennis J. , Levien Terri L. , Baker Danial E.
Published: February 2013

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. Subscribers to The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. A drug class review is now published monthly with The Formulary Monograph Service.

Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The February 2013 monograph topics are tofacitinib, cabozantinib, suvorexant, vortioxetine, and apremilast. The DUE/MUE is on tofacitinib.
Approvals, Submission, and Important Labeling Changes for US Marketed Pharmaceuticals
Authors: Baker Danial E.
Published: February 2013

This monthly feature will help readers keep current on new drugs, new indications, dosage forms, and safety-related changes in labeling or use. Efforts have been made to ensure the accuracy of this information; however, if there are any questions, please let me know at bakerdan@wsu.edu .
Primary Venous Thromboembolism Prophylaxis in Ambulatory Cancer Patients
Authors: Aikens Garrett B , Rivey Michael P , Hansen Carly J
Published: February 2013

OBJECTIVE:

To summarize and review current medical literature regarding the efficacy and safety of antithrombotic therapy for primary venous thromboembolism (VTE) prophylaxis in various ambulatory cancer populations.

DATA SOURCES:

A literature search was conducted in PubMed (1966-September 2012) and International Pharmaceutical Abstracts (1970-September 2012) using the terms venous thromboembolism, primary prophylaxis, anticoagulation, antithrombotic agents, cancer, and ambulatory. The bibliographies of pertinent studies and topic articles were reviewed for additional references.

STUDY SELECTION AND DATA EXTRACTION:

All English-language articles were evaluated for inclusion. All randomized trials were included in the review.

DATA SYNTHESIS:

Malignancy has been identified as a major independent risk factor for the development of VTE in the surgical, medically ill, and ambulatory populations. Primary VTE prophylaxis has been identified as an area of great impact in cancer patients because of the difficulties associated with the treatment of VTE and the greater risk for its recurrence in this population. Although primary VTE prophylaxis is recommended in all surgical and hospitalized cancer patients without contraindications to anticoagulants, its role in ambulatory cancer patients is less certain because of varying patient, cancer, and treatment-related factors. Fourteen randomized studies have investigated the use of antithrombotic agents for primary VTE prophylaxis in ambulatory cancer patients. Strong evidence for primary prophylaxis exists for several populations with advanced or metastatic cancer considered to be at high risk, including those with pancreatic cancer, lung cancer, or multiple myeloma. Evidence is inconsistent or lacking for lower risk cancer populations, such as those with breast cancer, or for those with malignant glioma, which carries a high risk for VTE and bleeding relative to the general ambulatory cancer population.

CONCLUSIONS:

Use of antithrombotic agents has reduced the rate of primary VTE, with minimal increases in bleeding risk in specific ambulatory cancer populations. Further investigation is needed to guide and narrow recommendations for primary VTE prophylaxis in ambulatory cancer patients.
Review of Continuous-Infusion Vancomycin
Authors: DiMondi V Paul , Rafferty Kelly
Published: February 2013

OBJECTIVE:

To evaluate the efficacy and safety of administering vancomycin as a continuous infusion.

DATA SOURCES:

Literature was accessed through MEDLINE (1977-September 2012), Embase (1977-September 2012), and Google Scholar, using the terms vancomycin, continuous, discontinuous, infusion, pharmacokinetics, pharmacodynamics, and nephrotoxicity. In addition, reference citations from publications identified were reviewed.

STUDY SELECTION AND DATA EXTRACTION:

All English-language articles identified from the data sources were evaluated. Studies including more than 30 adults were included in the safety and efficacy review.

DATA SYNTHESIS:

Infections due to methicillin-resistant Staphylococcus aureus (MRSA) carry a significant risk of morbidity and mortality. Vancomycin is commonly prescribed for invasive MRSA infections and has been traditionally administered as an intermittent infusion. Administering vancomycin as a continuous infusion is a novel approach to improving its efficacy and safety profile. Fourteen clinical trials were reviewed (2 prospective, 1 meta-analysis, 11 retrospective). The pharmacodynamic profiles between continuous-infusion vancomycin and intermittent-infusion vancomycin were comparable. Continuous-infusion therapy did not significantly improve the efficacy of vancomycin in the treatment of invasive MRSA infections. Conflicting results exist regarding the safety profile of continuous-infusion compared with intermittent-infusion vancomycin. The only published prospective randomized clinical trial comparing continuous infusion with intermittent therapy found no significant difference in the rates of nephrotoxicity. The data from retrospective studies are heterogeneous and show variable rates of nephrotoxicity. In general, compatibility information for administering vancomycin as a continuous infusion is unavailable.

CONCLUSIONS:

Overall, currently available evidence is insufficient to conclude whether an improvement in vancomycin efficacy exists when it is administered as a continuous infusion. The risk of nephrotoxicity associated with continuous-infusion vancomycin requires further investigation in prospective randomized trials. Specific patient populations that would benefit from continuous-infusion vancomycin have yet to be determined.
Anemia Management in Patients with Chronic Viral Hepatitis C
Authors: Hynicka Lauren M , Heil Emily L
Published: February 2013

OBJECTIVE:

To review the literature regarding current strategies for the management of anemia associated with treatment for chronic viral hepatitis C (HCV) in adults.

DATA SOURCES:

The MEDLINE/PubMed, EMBASE, and Cochrane databases were searched (January 1980-October 2012) for articles in English using the search terms anemia, ribavirin, dose reduction, erythropoietin stimulating agents, hepatitis C, HIV, liver transplant, telaprevir, and boceprevir.

STUDY SELECTION AND DATA EXTRACTION:

All relevant original studies, meta-analyses, systematic reviews, guidelines, and review articles were assessed for inclusion. References from pertinent articles were examined for additional content not found during the initial search.

DATA SYNTHESIS:

Standard of care for patients infected with HCV genotype 1 now requires a triple therapy regimen including an HCV NS3 protease inhibitor. These regimens lead to significantly higher rates of anemia compared to prior dual therapy regimens. Development of an optimal management strategy should begin with risk stratification. Ribavirin dose reductions have been recommended in the package inserts for the pegylated interferon products and studies have demonstrated the need for maintenance of 80% of the initial ribavirin dose to achieve optimal sustained virologic response (SVR) with dual therapy. The use of erythropoietin-stimulating agents has been shown to be effective for anemia caused by peginterferon and ribavirin without compromising SVR rates. Limited data have been published regarding the management of anemia with triple therapy; however, efficacy studies for boceprevir and telaprevir have used ribavirin dose reduction and erythropoietin-stimulating agents to successfully manage anemia.

CONCLUSIONS:

Anemia is a common adverse event associated with the use of ribavirin, and, more recently, the new HCV protease inhibitors. Ribavirin dose reduction should continue to be used as an initial anemia management strategy, with the use of erythropoietin alfa 40,000 units once weekly reserved for patients whose hemoglobin does not adequately respond to initial management strategies.
Discordant aPTT and Anti-Xa Values and Outcomes in Hospitalized Patients Treated with Intravenous Unfractionated Heparin
Authors: Price Elizabeth A , Jin Jing , Nguyen Huong Marie , Krishnan Gomathi , Bowen Raffick , Zehnder James L
Published: February 2013

BACKGROUND:

Both the activated partial thromboplastin time (aPTT) and anti-Xa assay can be used to monitor unfractionated heparin (UFH). Following implementation of an anti-Xa method for heparin dosing protocols in our hospital, we became aware of many patients with discordant aPTT and anti-Xa values.

OBJECTIVE:

To determine the frequency of discordant aPTT and anti-Xa values in a large cohort of hospitalized patients treated with UFH, as well as the demographics, coagulation status, indication for UFH, and clinical outcomes in this population.

METHODS:

All aPTT and anti-Xa values from adults hospitalized between February and August 2009 at Stanford Hospital who were treated with UFH were analyzed. All samples were drawn simultaneously. A polynomial fit correlating aPTT and anti-Xa with a 99% confidence limit was designed. Paired aPTT/anti-Xa values were grouped according to whether the paired values fell within or outside of the concordant area. Patients were placed into groups based on concordance status, and clinical outcomes were assessed.

RESULTS:

A total of 2321 paired values from 539 patients were studied; 42% of data pairs had a high aPTT value relative to the anti-Xa value. Patients with elevated baseline prothrombin time/international normalized ratio or aPTT frequently demonstrated disproportionate relative prolongation of the aPTT. Patients with at least 2 consecutive high aPTT to anti-Xa values had increased 21-day major bleeding (9% vs 3%; p = 0.0316) and 30-day mortality (14% dead vs 5% dead at 30 days; p = 0.0202) compared with patients with consistently concordant values.

CONCLUSIONS:

aPTT and anti-Xa values are frequently discordant when used to measure UFH in hospitalized patients. A disproportionate prolongation of the aPTT relative to the anti-Xa was the most common discordant pattern in our study. Patients with relatively high aPTT to anti-Xa values appear to be at increased risk of adverse outcomes. Monitoring both aPTT and Xa values may have utility in managing such patients.
Noble Drew Ali's “Clean and Pure Nation”
Authors: Clark Emily Suzanne
Published: February 2013

In the 1920s, the theology, racial history, and healing ways of the Moorish Science Temple of America mediated racial uplift and contemporary health concerns. In 1927, Moorish Science Temple founder Noble Drew Ali created the Moorish Manufacturing Corporation to market his line of healing teas, tonics, and oils. The historiography of the Moorish Science Temple often overlooks these products, but when put in relation with Ali's concept of Moorish identity and the group's approach to physical and spiritual health, these products emerge as material expressions of foundational Moorish Science Temple beliefs. Ali's dedication to keeping the Moors racially distinct and religiously clean and pure were mutually reinforcing and interpenetrating concerns. Furthermore, his vision of the Moorish nation and its material culture reflected larger trends in health, consumerism, and theological expression within American religious history.
Acupuncture blocks cold stress-induced increases in the hypothalamus–pituitary–adrenal axis in the rat
Authors: Eshkevari Ladan , Permaul Eva , Mulroney Susan E
Published: February 2013

Electroacupuncture (EA) is used to treat chronic stress; however, its mechanism(s) of action in allaying stress remains unclear. The interplay of stress hormones of the hypothalamus–pituitary–adrenal axis (HPA) and the sympathetic nervous system (SNS) is critical in the stress response. Our objective was to determine whether EA at acupoint, stomach 36 (EA St36) is effective in preventing chronic cold stress-induced increased hormone levels in the rat by examining four groups of animals, three of which were exposed to cold and one of which was a non-treatment control group. Before exposure to the cold, two groups were treated with either EA St36, or Sham-EA, before 10 days of cold stress. The EA St36 animals demonstrated a significant decrease in peripheral HP hormones (ACTH and CORT) compared with stress animals (P<0.05). These effects were specific; rats receiving Sham-EA had elevation of these hormones, similar to the stress-only animals. These effects were mirrored centrally in the brain; CRH levels were significantly (P<0.05) reduced in EA St36 animals compared with the other animals. Finally, EA effect on peripheral and adrenal SNS hormones (norepinephrine (NE) and neuropeptide Y (NPY) respectively) was examined, with no significant difference noted in adrenal tyrosine hydroxylase or circulating NE in any of the groups. However, EA St36 was effective in preventing stress-induced elevation is adrenal Npy mRNA. These results indicate that EA St36 blocks the chronic stress-induced elevations in the HPA and the sympathetic NPY pathway, which may be a mechanism for its specific stress-allaying effects.
Sex-Induced Silencing Operates During Opposite-Sex and Unisexual Reproduction in Cryptococcus neoformans
Authors: Wang Xuying , Darwiche Sabrina , Heitman Joseph
Published: February 2013

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic transition from yeast to hyphae during a-α opposite-sex mating and α-α unisexual reproduction (same-sex mating). Infectious spores are generated during both processes. We previously identified a sex-induced silencing (SIS) pathway in the C. neoformans serotype A var. grubii lineage, in which tandem transgene arrays trigger RNAi-dependent gene silencing at a high frequency during a-α opposite-sex mating, but at an ∼250-fold lower frequency during asexual mitotic vegetative growth. Here we report that SIS also operates during α-α unisexual reproduction. A self-fertile strain containing either SXI2a-URA5 or NEO-URA5 transgene arrays exhibited an elevated silencing frequency during solo and unisexual mating compared with mitotic vegetative growth. We also found that SIS operates at a similar efficiency on transgene arrays of the same copy number during either α-α unisexual reproduction or a-α opposite-sex mating. URA5-derived small RNAs were detected in the silenced progeny of α-α unisexual reproduction and RNAi core components were required, providing evidence that SIS induced by same-sex mating is also mediated by RNAi via sequence-specific small RNAs. In addition, our data show that the SIS RNAi pathway also operates to defend the genome via squelching transposon activity during same-sex mating as it does during opposite-sex mating. Taken together, our results confirm that SIS is conserved between the divergent C. neoformans serotype A and serotype D cryptic sibling species.
Characterization of Thin ZnO Films by Vacuum Ultra-Violet Reflectometry
Authors: Gumprecht T. , Petrik P. , Roeder G. , Schellenberger M. , Pfitzner L. , Pollakowski B. , Beckhoff B.
Published: February 2013

ZnO has a huge potential and is already a crucial material in a range of key technologies from photovoltaics to opto and printed electronics. ZnO is being characterized by versatile metrologies to reveal electrical, optical, structural and other parameters with the aim of process optimization for best device performance. The aim of the present work is to reveal the capabilities of vacuum ultra-violet (VUV) reflectometry for the characterization of ZnO films of nominally 50 nm, doped by Ga and In. Optical metrologies have already shown to be able to sensitively measure the gap energy, the exciton strength, the density, the surface nanoroughness and a range of technologically important structural and material parameters. It has also been shown that these optical properties closely correlate with the most important electrical properties like the carrier density and hence the specific resistance of the film. We show that VUV reflectometry is a highly sensitive optical method that is capable of the characterization of crucial film properties. Our results have been cross-checked by reference methods such as ellipsometry and X-ray fluorescence.
Diffusion brazing of γ-TiAl-alloys: Investigations of the joint by electron microscopy and high-energy X-ray diffraction
Authors: Hauschildt Katja , Stark Andreas , Lorenz Uwe , Schell Norbert , Fischer Torben , Blankenburg Malte , Mueller Martin , Pyczak Florian
Published: February 2013

Diffusion brazing is a potential method to repair parts made from TiAl-alloys. Two different brazing materials with varying contents of titanium, iron and nickel were investigated. The phases present in the brazed zone were identified by high energy X-ray diffraction (HEXRD) at the material science beamline HEMS at the PETRA III synchrotron facility at DESY in Hamburg, Germany, and the microstructure was characterised by scanning electron microscopy (SEM). The braze zone itself is composed of one to two transitional layers from the substrate material to the middle of the joint. Near the substrate material the phase constitution reassembles a TiAl-alloy while the middle of the joint is similar to α/β-titanium alloys. Besides phases commonly encountered in TiAl-alloys such as γ, α2 and β, additional phases, which are related to the presence of nickel or iron as melting point depressing elements are present. The microstructure of the brazed zone changes significantly during a subsequent heat treatment.
Toward an Inverse Approach for the Design of Small-Molecule Fixating Catalysts
Authors: Weymuth Thomas , Reiher Markus
Published: February 2013

Within an inverse design approach applied to a nitrogen-fixation catalyst we discuss options for calculating “jacket” potentials that fulfill a purpose-oriented target requirement. As a target requirement we choose the vanishing geometric gradients on all atoms of a subsystem consisting of a metal center binding the small molecule to be activated - in our case dinitrogen. The additional potential can be represented within a full quantum model or by a sequence of approximations of which a field of electrostatic point charges is the simplest. In order to analyze the feasibility of this approach, we dissect a known dinitrogen-fixating complex and analyze its ligand environment expressed by the “jacket” potential. It is discussed how this ligand-bypotential replacement can be generalized for future applications that eventually allow us to find a competitive synthetic nitrogen-fixation transition metal complex. It can be expected that such a ligand-by-potential replacement approach will be applicable to any type of host-guest chemical process.
Microstructure and Local Charge Distribution in Hydrogenated Nanocrystalline Silicon under Illumination Studied by Electrostatic Force Microscopy.
Authors: Priti Rubana Bahar , Bommisetty Venkat
Published: February 2013

Hydrogenated nanocrystalline silicon (nc-Si:H) is a promising absorber material for photovoltaic applications. Nanoscale electrical conductivity and overall electronic quality of this material are significantly affected by film microstructure, specifically the density and dimension of grains and grain-boundaries (GB). Local charge distribution at grains and grain/GB interfaces of nc-Si:H was studied by Electrostatic Force Microscopy (EFM) in constant force mode under illumination of white LED. Bias voltage from -3V to +3V was applied on the tip. Scanning Kelvin Force (KFM) images were taken before and after illumination to study the change in surface photovoltage (SP). EFM and KFM analysis were combined with film topography to draw a correlation between surface morphology and nanoscale charge distribution in this material. After illumination, small blister like structures were observed whose size and density increase with time. Raman spectroscopy confirmed these new structures as nanocrystalline silicon. This change was assumed due to relaxation of strained Si-Si bonds as an effect of photo response. Nanocrystalline grain interiors were at lower potential and amorphous grain boundaries were at higher potential for negative bias; it was opposite for positive bias. Change in polarity in bias voltage reversed the polarity of the potential in grains and GBs indicating the dominance of negative type of defects. Further study with current sensing AFM in dark and illumination with variable bias voltages will be able to identify the type and density of defects in grains and grain/GB interfaces.
Sputter deposited ZnO porous films for sensing applications
Authors: Borysiewicz Michał A. , Dynowska Elżbieta , Kolkovsky Valery , Wielgus Maciej , Gołaszewska Krystyna , Kamińska Eliana , Ekielski Marek , Struk Przemysław , Pustelny Tadeusz , Piotrowska Anna
Published: February 2013

Nanoporous ZnO films are fabricated using a two step approach: sputter deposition of porous Zn followed by an ex-situ annealing in an oxygen flow at 400°C. The created structures have a porosity of 34% enabling use in surface-based absorption sensors. The films are used in a resistance-based sensor allowing easy discrimination between liquid methanol and ethanol by resistance measurements and also in a transmission-based sensor to detect NO2, NH3 and H2 gases in concentration as low as 500 ppm.
Introducing Antibacterial Properties to Paper Towels Through the Use of Selenium Nanoparticles
Authors: Wang Qi , Webster Thomas J.
Published: February 2013

Bacterial infections are commonly found on paper towels and other paper products leading to the potential spread of bacteria and consequent health concerns. The objective of this in vitro study was to introduce antibacterial properties to paper towel surfaces by coating them with selenium nanoparticles. Scanning electron microscopy was used to measure the size and distribution of the selenium coatings on the paper towels. Atomic force microscopy was used to measure the surface roughness of paper towels before and after coated with selenium nanoparticles. The amount of selenium precipitated on the paper towels was measured by atomic absorption spectroscopy. In vitro bacterial studies with Staphylococcus aureus were conducted to assess the effectiveness of the selenium coating at inhibiting bacterial growth. Results showed that the selenium nanoparticles coated on the paper towel surface were well distributed and semispherical about 50nm in diameter. Most importantly, the selenium nanoparticle coated paper towels inhibited S. aureus growth by 90% after 24 hours and 72 hours compared with the uncoated paper towels. Thus, the study showed that nano-selenium coated paper towels may lead to an increased eradication of bacteria to more effectively clean a wide-range of clinical environments, thus, improving health.
Modelling the Activation of H2 on Spent Fuel Surface and Inhibiting Effect of UO2 Dissolution
Authors: Duro L. , Riba O. , Martínez-Esparza A. , Bruno J.
Published: February 2013

The dissolution of spent nuclear fuel is defined in two different time steps, i) the Instant Release Fraction (IRF) occurring shortly after water contacts the solid spent fuel and responsible of the fast release of those radionuclides that have been accumulated in the zones of the spent fuel pellet with low confinement, such as gap and grain boundaries and ii) the long term release of radionuclides confined in the spent fuel matrix, much slower and dependent on the conditions of the water that contacts the spent fuel.

Several models have been developed to date to explain the dissolution behavior of spent nuclear fuel under disposal conditions. The Matrix Alteration Model (MAM) is one of the most evolved radiolytic models describing the dissolution mechanism in which an Alteration/Dissolution source term model is based on the oxidative dissolution of spent fuel. Under deep repository conditions and at the expected of water contacting time (after 1000 years of spent fuel storage), α radiation will be the main contributor to water radiolysis. In the current study, simulations evaluating the effect of surface area on the alteration/dissolution of spent fuel matrix are performed considering different particle sizes of spent fuel and simulations integrating the actinides dissolution have been performed considering the precipitation of secondary phases.
Corrosion Study of SIMFUEL in Aerated Carbonate Solution Containing Calcium and Silicate
Authors: Jung Hundal , Ahn Tae , Pabalan Roberto , Pickett David
Published: February 2013

The corrosion behavior of simulated spent nuclear fuel (SIMFUEL) was investigated using electrochemical impedance spectroscopy and solution chemistry analyses. The SIMFUEL was exposed to aerated solutions of NaCl+NaHCO3 with and without calcium (Ca) and silicate. Two SIMFUEL compositions were studied, representing spent nuclear fuel (SNF) corresponding to 3 or 6 at % burnup in terms of fission product equivalents of surrogate elements. For all tested cases, the polarization resistance increased with increased immersion time, indicating possible blocking effects due to accumulation of corrosion products on the SIMFUEL surface. The potential-pH diagram suggests formation of schoepite that may cause the increase in the polarization resistance. The addition of Ca and silicate produced no measureable change in the polarization resistance measured at the corrosion potential. The dissolution rate ranged from 1 to 3 mg/m2-day, which is similar to the range of dissolution rates for SIMFUEL and SNF reported in the literature for comparable conditions. SIMFUEL burnup did not have a major effect on the dissolution rate. Analysis of the solution chemistry shows that uranium is the dominant element dissolved in the posttest solutions, and the dissolution rates calculated from uranium (U) concentrations are consistent with the dissolution rates obtained from impedance measurements. Simulated-fission product elements (i.e., barium, molybdenum, strontium, and zirconium) dissolved from the SIMFUEL electrode at a relatively high rate. Sorption test results indicated significant sorption of U onto the oxide formed on stainless steel. Electrochemical methods were found to be effective for measuring the uranium dissolution rate in real time.
A breakup model of Jetting formation of Explosively Loaded Granular Shells
Authors: Xue Kun
Published: February 2013

This paper investigates the underlying physics governing the explosion driven expansion and fragmentation of spherical beds packed of partially saturated sand with varying mass fractions of interstitial oil. The breakup onset of the sand shells is characterized by the formation of fragments/agglomerates consisting of a large number of constituent grains, which in later time present themselves as prolific and regular jetting streams. Test data show a postponed jetting formation when sand shells are subject to the explosion with a higher detonation velocity, meanwhile a reduced jet mass scale is observed. A kinetic energy driven breakup model is proposed based on the instability criterion involving the opposing forces of stabilizing inertial pressures and destabilizing viscous resistance. This analytical model is capable of predicting the onset of granular material fragmentation as well as the characteristic fragment size, which is consistent with the experimental results.
A humanistic gift from the Brazilian Emperor D. Pedro II (1825 - 1891) to the Brazilian nation: the first lunatic asylum in Latin America
Authors: Nardi Antonio E. , Silva Adriana Cardoso , Hallak Jaime E. , Crippa José A.
Published: February 2013

Until the beginning of the 19th century, psychiatric patients did not receive specialized treatment. The problem that was posed by the presence of psychiatric patients in the Santas Casas de Misericórdia and the social pressure from this issue culminated in a Decree of the Brazilian Emperor, D. Pedro II, on July 18, 1841. The “Lunatic Palace” was the first institution in Latin America exclusively designed for mental patients. It was built between 1842 and 1852 and is an example of neoclassical architecture in Brazil, located at Saudade Beach in the city of Rio de Janeiro. In the 1930s and 1940s, the D. Pedro II Hospital was overcrowded, and patients were gradually transferred to other hospitals. By September of 1944, all the patients had been transferred and the hospital was deactivated. Key words: psychiatry, history, madness.
Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine
Authors: Ferreira Karen S. , Eckeli Alan , Dach Fabíola , Speciali José G.
Published: February 2013

OBJECTIVE: The pathophysiology of migraine and restless legs syndrome (RLS) seems to involve inherited mechanism and dysfunction of the dopaminergic system. Previous articles have shown that the frequency of RLS is higher in migraine patients than in controls. We conducted a study to evaluate comorbidities, medication used and depressive symptoms that can explain the relation between migraine and RLS. METHODS: A case-control study was performed in which patients with migraine (n=72) and a control group without migraine (n=72) were interviewed. Data including RLS diagnosis, depressive symptoms, comorbidities and drugs used were evaluated. RESULTS: There was a significant association between migraine and RLS (p=0.01), but comorbidities such as diabetes, hypertension, anemia and drugs used did not explain this association. Depression scores, as measured by the Beck Depression Inventory, were higher in migraine patients with RLS (p =0.04). CONCLUSION: No specific factors explaining the association between migraine and RLS were found. Symptoms of depression were more frequent in patients with migraine and RLS.
Quality of life and sleep in obese adolescents
Authors: Turco Giovina , Bobbio Tatiana , Reimão Rubens , Rossini Sueli , Pereira Helen , Barros Filho Antonio
Published: February 2013

Obesity and sleep disorders in adolescence are strongly associated, and they impact both on the health and on quality of life (QL) in this age group. OBJECTIVE: To comparatively assess QL and sleep in obese and eutrophic adolescents, who are older than ten years of age. METHODS: Cross-sectional study including obese adolescents. This analysis was carried out between August 2009 and August 2010. The Control (eutrophic) Group comprised schoolchildren recruited from State schools in the city of Americana, in São Paulo State, Brazil. Instruments applied included a standardized questionnaire, the Sleep Behavior Questionnaire (SBQ), and the Pediatric QL Inventory (PedsQL TM 4.0). RESULTS: The obese adolescents had poorer QL on physical (p<0.001), emotional (p=0.03), and social (p=0.002) functioning domains. A difference in mean psychosocial functioning was found between the groups (p=0.009) with obese subjects having a mean score of 69.5 (±16.0) and in eutrophic individuals of 76.2 (±16.7). A greater number of sleep problems was evident in the Obese Group (p=0.03). Conclusions: The obese adolescents had an impaired QL and a higher frequency of sleep problems compared to the eutrophic subjects.
Sazonalidade no balanço de energia em áreas de cultivo de soja na Amazônia
Authors: Souza Paulo Jorge de Oliveira Ponte de , Ribeiro Aristides , Rocha Edson José Paulino da , Farias José Renato Bouças , Souza Everaldo Barreiros de
Published: February 2013

Neste trabalho, avaliou-se o balanço de energia na cultura soja (Glycine max (L.) Merrill), variedade Tracajá, durante a safra e entressafra, em uma área de avanço de fronteira agrícola na Amazônia, por meio do método da razão de Bowen. Durante quase todo o ciclo da cultura, maior parte da energia foi consumida na forma de calor latente, principalmente durante as fases de florescimento e frutificação. Tal característica esteve relacionada à elevada condutância estomática foliar da soja e à disponibilidade de água na região. Próximo ao fim do ciclo ocorreu uma inversão na partição de energia entre os componentes H e LE, quando maior parte da energia foi usada no aquecimento do ar (79% do saldo de radiação). Durante a entressafra observou-se a redução de 75% no fluxo de calor latente e aumento considerável de 180% no fluxo de calor sensível comparado ao encontrada durante o ciclo.
A indústria de publicação contra o acesso aberto
Authors: Camargo Jr Kenneth Rochel de
Published: February 2013

A publicação em revistas de acesso aberto cresceu expressivamente nos últimos anos. As publicações de acesso fechado, por sua vez, têm custo de acesso cada vez mais elevado, por se beneficiarem de um modelo econômico peculiar: o trabalho relevante e os insumos essenciais são entregues gratuitamente a fornecedores que contam com um mercado cativo, praticamente sem concorrência. O mercado editorial é altamente oligopolizado, característico de indústrias que trabalham com o regime de copyright. Isso contribui para a elevação dos preços de seus produtos. Políticas mandatórias de acesso aberto, como a determinada pela agência National Institutes of Health, constituem-se em ameaça a esse modelo de negócios e são enfrentadas pela indústria em várias frentes, incluindo a passagem de legislação para sabotar tais iniciativas. O objetivo deste comentário foi apresentar alguns aspectos principais desse enfrentamento e sugerir possíveis estratégias de incremento da publicação de acesso aberto em nosso meio.
Assistência em saúde mental sustentada no modelo psicossocial: narrativas de familiares e pessoas com transtorno mental
Authors: Borba Letícia de Oliveira , Guimarães Andrea Noeremberg , Mazza Verônica de Azevedo , Maftum Mariluci Alves
Published: February 2013

Esta pesquisa foi realizada com o método da história oral temática e desenvolvida no ano de 2009, em Curitiba, com oito colaboradores pertencentes a três famílias que tinham um integrante com transtorno mental. O objetivo do estudo foi descrever a percepção de familiares e de portadores de transtorno mental sobre a assistência em saúde mental sustentada no modelo psicossocial. Os dados foram obtidos por meio de entrevista semiestruturada, analisados e apresentados de maneira descritiva. Os colaboradores consideraram os serviços extra-hospitalares, como o Centro de Atenção Psicossocial e os ambulatórios de saúde mental, estratégias inovadoras, e mencionaram o atendimento por equipe multiprofissional, a mediação de conflitos familiares e o princípio de territorialidade. Destacaram o acompanhamento do portador de transtorno mental pela Unidade Básica de Saúde e ressaltaram a importância das associações na rede de saúde mental. Atribuíram à inclusão da família no tratamento a melhora na relação familiar e a aceitação da doença.
Identificação das intervenções de enfermagem na Atenção Primária à Saúde: parâmetro para o dimensionamento de trabalhadores
Authors: Bonfim Daiana , Gaidzinski Raquel Rapone , Santos Flávia Monique , Gonçales Camila de Souza , Fugulin Fernanda Maria Togeiro
Published: February 2013

Na Atenção Primária à Saúde (APS) o quadro de trabalhadores de enfermagem é planejado de forma empírica, gerando distorção entre a alocação e a real necessidade das unidades de saúde. O objetivo deste trabalho foi identificar as intervenções de enfermagem na APS para subsidiar o dimensionamento dos trabalhadores. Foram utilizadas as seguintes fontes: revisão bibliográfica em bases de dados no período de 1999-2009; observação em campo em Unidade de Saúde da Família; levantamento em prontuários de famílias; mapeamento das atividades em intervenções de enfermagem segundo a taxonomia Nursing Interventions Classification e validação dessas intervenções. Identificaram-se 169 atividades: 11 atividades associadas; 5 pessoais; e 153 de cuidados diretos e indiretos que foram mapeadas e validadas em 7 domínios, 15 classes e 46 intervenções da NIC. O estudo possibilitou o reconhecimento das práticas de enfermagem na APS por meio de uma linguagem padronizada, subsidiando a sua aplicação na construção de instrumentos para a identificação da carga de trabalho.
Síndrome de Burnout em residentes multiprofissionais de uma universidade pública
Authors: Guido Laura de Azevedo , Silva Rodrigo Marques da , Goulart Carolina Tonini , Bolzan Maria Elaine de Oliveira , Lopes Luiz Felipe Dias
Published: February 2013

Os Programas de Residência Multiprofissional buscam romper com os paradigmas em relação à formação de profissionais para o Sistema Único de Saúde (SUS) e contribuir para qualificar os serviços de saúde a partir de ações inovadoras. Entretanto, características específicas desses programas podem agregar estressores aos residentes e, levarem à Sídrome de Burnout. Dessa forma, verificou-se a ocorrência da Síndrome de Burnout nos Residentes Multiprofissionais da Universidade Federal de Santa Maria. Este estudo trata-se de um estudo descritivo, transversal e quantitativo. Aplicaram-se um formulário de dados sociodemográficos e o Versão Human Service Survey do Marlash Burnout Inventory em 37 residentes, entre abril e junho de 2011. Observou-se que 37,84% apresentaram Alta Exaustão Emocional; 43,24%, Alta Despersonalização; e 48,65%, Baixa Realização Profissional. Na associação dos domínios, verificou-se que 27% apresentaram indicativo para Síndrome de Burnout. Os residentes pesquisados estão expostos aos estressores da profissão e da formação, o que pode favorecer a ocorrência da síndrome nesses profissionais.