bluuebunny/crossref_metadata_2025 huggingface dataset:
(IM)PERFECTIVIDADE, ACIONALIDADE E ENSINO: USANDO NOÇÕES DA SEMÂNTICA FORMAL NA EDUCAÇÃO BÁSICA
Authors: Souza Érica Azevedo de
Published: February 2024

Este relato de pesquisa tem o objetivo de descrever a semântica da flexão de tempo pretérito do português brasileiro e sua relação com o conceito de (a)telicidade e de duração. A pesquisa tem como base a teoria da Semântica Formal e, por isso, através de uma metodologia introspectiva da análise dos dados e de contribuições das noções de tempo linguístico, aspecto gramatical (Klein, 1994) e aspecto lexical (Vendler, 1967), buscou-se mostrar que as combinações entre o morfema temporal-aspectual dos eventos no pretérito do indicativo do português brasileiro com o léxico podem gerar diferenças interpretativas em sentenças declarativas. Além disso, foram criadas três propostas didáticas baseadas na metodologia da aprendizagem linguística ativa (Pilati, 2017) como sugestão para a abordagem dos assuntos discutidos pela teoria apresentada no ensino básico.
An update on bridge carbon dioxide footprint data
Authors: Collings David , Murthy Spandan
Published: February 2024

Transport infrastructure accounts for a significant proportion of the world's carbon dioxide emissions. Bridges and viaducts use a significant amount of steel and cement; these two industries alone amount to about 16% of the world's total carbon dioxide emissions. The carbon dioxide footprint of bridges and viaducts has been studied, and this paper adds some additional data from various sources. The data analysis is extended, and the key issues of substructure carbon dioxide and bridge size noted in the original research are explored in more detail. New datasets of bridge carbon dioxide with time, with span and carbon dioxide in substructures are introduced to note progress towards net zero. The paper indicates that there has been little change in carbon dioxide content over the past 60 years. The paper summarises the key conclusions from the new data and gives five recommendations towards net zero, along with key performance indicators of good bridge designs considering carbon dioxide footprint.
A two-scale study on the influence of biopolymer enhancement on drying granular materials
Authors: Chen R. , Veveakis M.
Published: February 2024

Cracking resulting from drying (constrained dehydration) poses a significant challenge in geomaterials, impacting their mechanical performance. To address this problem, extensive efforts have been made to prevent or mitigate the occurrence of cracks, with recent attention focused on the utilisation of biopolymers. This letter investigates the influence of varying concentrations of the xanthan biopolymer on the mechanical response of granular materials, examining both macro and micro scales. The strength changes of the soil were evaluated through desiccation experiments, analysing the appearance and progression of failure on the macro scale. The findings of this study demonstrate that failure (cracking) progression is mitigated and eventually eliminated by increasing the concentration of the additive xanthan. Additionally, capillary experiments were conducted to assess the changes in attraction and the development of capillary bridges on the micro-scale. They indicate that the formation of hydrogel bridges significantly enhances particle attraction, thereby increasing its macro-resistance to cracking.
Management skills and the quality of accounting information in Brazil
Authors: Fagundes Fabio Marsicano , Brugni Talles Vianna , Nossa Silvania Neris
Published: February 2024

This study aims to analyze managerial skills in the practice of earnings management via earnings smoothing and accruals in B3 companies. To this end, a quantitative and descriptive study was conducted using data from the Economática database, with a sample of 966 observations from 2010 to 2020. Demerjian et al.’s (2012) model was used to measure managerial skill. Its efficiency parameters are the manager’s characteristics in using resources to generate revenue. The models by Leuz et al. (2003) and McNichols (2002) were used to measure smoothing and levels of earnings management. The results showed that, on average, more skillful managers tend to smooth and manage earnings at higher levels than less skilled managers, indicating that in Brazil, on average, more skillful managers reduce the quality of Brazilian firms’ earnings. This paper contributes to the literature and fills a gap regarding managerial skills and the impact on the results of Brazilian companies. It shows that, in Brazil, managerial skill is associated with smoothing and earnings management practices and sheds light on interested parties regarding the influence of the profile of managers and their ability to influence the numbers released in the Brazilian market.
Investimentos ESG na pandemia da Covid-19
Authors: Moutinho Rafael , Silva Ricardo Luiz Menezes da
Published: February 2024

O objetivo deste estudo é analisar o efeito do investimento em fatores ambientais, sociais e de governança (ESG) no desempenho financeiro de empresas brasileiras e no retorno anormal acumulado durante o período da pandemia de Covid-19. Para isso, foram comparadas duas carteiras teóricas do mercado brasileiro: uma composta pelas empresas do ISE e outra por empresas do Ibovespa. Analisou-se o impacto das variáveis de desempenho financeiro nos Retornos Anormais durante o período de pandemia de Covid-19, utilizando-se o método do Estudo de Evento. Este estudo obteve resultados mistos. As empresas do ISE obtiveram CAR mais elevados para o período da pandemia, demonstrando maior resiliência durante a crise. Além disso, observou-se menor volatilidade das ações ESG. Os resultados dos modelos de regressão não identificaram uma relação positiva entre os indicadores de rentabilidade e o CAR para empresas do ISE. Por outro lado, em linha com as hipóteses deste estudo, verificou-se uma associação positiva entre Q de Tobin de empresas ESG e o CAR. Esta pesquisa pode ser útil para acadêmicos e investidores, uma vez que amplia as evidências dos investimentos ESG em termos de desempenho financeiro em um mercado emergente, como o brasileiro, e sua resiliência em tempos de crise. Por fim, gestores, investidores, credores e demais profissionais podem se interessar pelos resultados desta pesquisa, uma vez que os investimentos ESG podem desenvolver uma vantagem competitiva, contribuindo para o sucesso do negócio a longo prazo.
Considerações sobre o método do fluxo de caixa descontado na apuração de haveres
Authors: Caríssimo Cláudio Roberto
Published: February 2024

O objetivo deste ensaio teórico é discutir, à luz da teoria contábil e de finanças, sobre o Acórdão - REsp 1.877.331 da 3ª Turma do Superior Tribunal de Justiça (STJ) que decidiu, para efeitos de Apuração de Haveres de sócio retirante, salvo determinação contida no Contrato Social, que o método do Fluxo de Caixa Descontado (FCD) não é pertinente. Como fundamento para a argumentação deste ensaio, foram incorporados os conceitos de ativo e a sua característica de geração de benefícios econômicos futuros. Para o ensaísta, essa característica é balizadora não só para a mensuração de ativos, como também para a mensuração do valor de uma empresa que é formada por um conjunto de ativos tangíveis e intangíveis. O Fluxo de Caixa Descontado é considerado um dos principais métodos de avaliação de empresas, sendo essencialmente financeiro, derivado da capacidade de geração de benefícios futuros que são projetados, descontados a valor presente, acrescentando ainda o valor da perpetuidade. A mensuração por este método pode considerar a empresa na situação em que se encontra, não sendo necessário projeções de crescimento, fatores macroeconômicos futuros, já que a jurisprudência considera que o futuro não pertence ao sócio retirante. Não obstante, não se pode desconsiderar a capacidade de geração destes benefícios econômicos, o que pode propiciar uma avaliação desprovida do valor justo, prejudicando assim uma das partes no litígio. Embasado nesses aspectos discutidos no ensaio, considera-se assim, a pertinência do uso do Fluxo de Caixa Descontado em processos de Apuração de Haveres.
O papel do valor adicionado total a distribuir para redução dos efeitos negativos da pandemia no preço das ações
Authors: Santos Geovane Camilo
Published: February 2024

Esta pesquisa tem como objetivo analisar a relação entre o valor adicionado total a distribuir e o preço das ações nos períodos antes, durante e pós-pandemia. Os dados foram coletados no site da Comissão de Valores Mobiliários (CVM) e Refinitiv Eikon®, resultando em uma amostra de 1.910 observações de empresas brasileiras, no período de 2010 a 2022 de todos os setores, exceto Atividade Governamental (por falta de dados). Os dados foram tratados por meio de estatística descritiva e do modelo de regressão Generalized Least Squares (GLS). Os resultados revelaram que: i) a divulgação do VATD é relevante para explicar o preço das ações; ii) há uma relação negativa entre o período da pandemia e o preço das ações; e iii) a interação entre o VATD e a pandemia tem relação positiva com o preço das ações. Os resultados contribuem com investidores, sugerindo que as informações disponíveis na Demonstração do Valor Adicionado (DVA) podem aumentar o preço das ações em períodos de maiores incertezas. Com os gestores, evidencia que a geração de mais riqueza pode aumentar o preço das ações, podendo ajudá-los na obtenção de melhores retornos, pois normalmente têm parte da remuneração atrelada ao desempenho das ações. E com os reguladores brasileiros, os resultados podem indicar que a obrigatoriedade da divulgação DVA no período da pandemia é relevante para auxiliar os stakeholders nas tomadas de decisões. A lacuna explorada nesta pesquisa é a falta da análise entre a relação do VATD e a pandemia. A relevância do estudo é por evidenciar aos stakeholders que informações da DVA contribuem para aumento do preço das ações em períodos de maior instabilidade. Portanto, o impacto do estudo é que os usuários podem utilizar-se das informações da DVA para precificação das ações, principalmente em períodos de maior instabilidade econômica.
Adopsi Literasi Fintech untuk E-Money di Kalangan Generasi Z
Authors: Yuliawati Tia , Hendrayati Heny , Cintyawati Cici , Furqon Chairul
Published: February 2024

The purpose of this study was to determine and analyze the effect of fintech literacy on actual usage of electronic money in Generation Z, as well as to determine and analyze the influence of perceived ease of use, perceived usefulness, and personal innovativeness on actual usage of electronic money in Generation Z. The method used in this study is a survey method with a verification approach. Where data is collected from a sample of 100 respondents through a questionnaire distributed through Google Form. Hypothesis testing is done using SEM Analysis with the help of SmartPLS 3.0 software. The results show that fintech literacy has a positive and significant effect on actual usage of electronic money. Perceived ease of use and perceived usefulness have no significant effect on actual usage of electronic money, while personal innovativeness has a positive and significant effect on actual usage of electronic money. Personal innovativeness is also known to be a factor that has the greatest influence on actual usage of electronic money in Generation Z. This research has implications for the development of management science, especially to see the effect of fintech literacy on actual usage of electronic money that can be used by the financial services sector as a basis for decision making.
Pendekatan Hierarki Kebutuhan Maslow pada Motivasi Pembelian Electric Vehicles di Indonesia
Authors: Rahardi Rafi Amani Muflih , Rachmawati Indira
Published: February 2024

The transportation sector is one of the largest contributors to the greenhouse effect. This causes consumers and industry to look for solutions to reduce the greenhouse effect, one of them is an Electric Vehicles (EV). EV is considered as one of the responses to reduce the use of oil energy and carbon emissions from the transportation sector. However, the EV success depends on the level of people's need for EV. Maslow's hierarchy of needs is widely used to understand consumer buying motivation and consumer buying behavior. This study aims to determine EV Purchase Motivation in Indonesia by using Maslow's Hierarchy of Needs approach. Questionnaires from 385 respondents were then analyzed using multiple linear regression models. Based on the research, the Openness to Experience variable has the most significant effect on EV Purchase Motivation, followed by Environmental Concern, Price Consciousness, and Self Esteem. Meanwhile, the Social Influences variable has a negative and insignificant effect on EV Purchase Motivation.. From a practical point of view, there are several useful recommendations for the government and also advice to automotive marketers and manufacturers.
Menggali Potensi Kinerja: Tinjauan Pelatihan dan Manajemen Karir di Institusi Polisi
Authors: Affandi Muhammad Khoer
Published: February 2024

The police is a state institution whose role is to provide protection and maintain the security of society and the state. This is expalined in law No. 2 of 2002 concerning the National Police of the Republic of Indonesia, article 5 pragraph 1. To improve the professionalism of police performance, superior human resources are neede as the main movers in institutions. Training is closely related to increasing the intellectual abilities neede to carry out better job duties and functions. A future career for employees wjo can achieve it is also an effort made by the institution so that employees can improve their performance for the future of police institution. This research aims to determine and analyze the influence of training and career management on the performance of Sukabumi City Police employees. This research was conducted using a quantitative approach. The population was 772 people, with a sample of 200 people taken using the Slovin formula. Research data was obtained using a questionnaire that had been tasted for validity and reliability. Data analysis uses multiple regression after testing the analysis requirements. The research results show that separately, training and career management have a positive effect on employee performance. Meanwhile, training and career management simultaneously have a positive effect on employee performance.
Eksplorasi Trends dalam Work Engagement dan Work Family Conflict dengan Metode Bibliometrik
Authors: Ciptagustia Annisa , Kusnendi Kusnendi , Perdana Yoga , Faldesiani Riske
Published: February 2024

The purpose of the study is a comprehensive picture of work engagement and work family conflict for the criteria of key authors, documents, and keywords and mapping the development of research through a bibliometric approach with computational mapping analysis using VOSviewer. This research used bibliometric analisis with VOSviewer sofware. This study used the Scopus database using A comma separated value (CSV) format consisting of 440 reference metadata used for analysis in VOSviewer in the period 1993-2023. Clustering of the network visualisation map was done using 2 keywords, namely, work engagement and work family conflict. The analysis showed that most of the publications were done in 2022 with 69 articles with a high number of citations in this field from researchers in the United States and China. A total of 11 articles were published in the International Journal Of Environmental Research And Public Health and the documents referenced or heavily cited came from the Journal Of Occupational And Environmental Medicine with 469 articles.
Keragaman Gender di Dewan Komisaris dan Risiko Perusahaan: Perspektif Teori Agensi Perilaku
Authors: Medidjati R Adam , Nugraha Nugraha , Heryana Toni , Hartono Pierdijono
Published: February 2024

The purpose of this study is to verify the influence of gender diversity in the Board of Commissioners on the financial risks of the company from the perspective of behavioral agency theory, where the presence of gender diversity in the board of commissioners can improve the ability of the board of commissioners to manage company risks. However, there is also the possibility that gender diversity on the board of commissioners may increase the company's risk. This can happen if there is a conflict between members of the board of commissioners of different genders, thereby disrupting the smooth decision-making process. The company's financial risk indicators measured in this study are Debt to Equity Ratio (DER) and Debt to Asset Ratio (DAR). This research study was conducted on companies incorporated in LQ45 with a research period from 2015 to 2020 as many as 51 companies. This study was conducted using secondary data and the data was processed using unbalanced panel data regression with the help of the EVIEWS 12 application. The results of this study show that gender diversity in the Board of Commissioners has a significant effect on DAR where an increase in the composition of the number of men will reduce DAR by -0.53 this means that gender diversity will increase the company's risk in DAR indicators. But on the contrary, this gender diversity does not have a significant effect on DER.
Analisis Komparasi Metode CAPM dan APT dalam Memprediksi Return Saham LQ45 2019-2021
Authors: Hartono Pierdijono , Nugraha Nugraha , Heryana Toni , Medidjati R. Adam
Published: February 2024

The investment climate is developing rapidly in Indonesia, many people are interested in investing, and the capital market is a common and legal place to invest. In investing, stocks are one of the long-term financial instruments traded on the capital market. The goal of investors in stock investment is to obtain the maximum stock return with a certain risk. Financial experts have developed two approaches to predict return on investment based on risk and use certain macroeconomic variables, the Capital Asset Pricing Model (CAPM) and the Arbitrage Pricing Theory (APT). This study aims to determine the best model between the CAPM and APT in determining the expected return on shares of companies that are members of the IDX LQ45 for the period 2019-2021. Data is processed using Unbalance Data Panel Analysis with the Eviews application. The results of data processing show that the CAPM method is more precise or accurate than the APT method.
Molluscicidal Activity of Entomopathogenic Fungus, Metarhizium Anisopliae (Hypocreales: Clavicipitaceae) Against Golden Apple Snails, Pomacea Canaliculata (Architaeniglossa: Ampullariidae)
Authors: Allahudin Mohamad Ikmal Hakim , Ann Jaisofi Anis Jazleena Syafiqah , Ling Ma Nyuk , Nagappan Thilahgavani , Ahmad Aziz , Ng Lee Chuen , Azmi Wahizatul Afzan
Published: February 2024

Golden Apple Snails (GAS, Pomacea canaliculata) is known in Malaysia as one of the world's worst invasive pest species, wreaking havoc on paddy fields by lowering rice yield dramatically. Farmers now employ chemical molluscicides to eliminate GAS, but these are expensive and have serious health and environmental consequences. Biological control agent using entomopathogenic fungus is preferred over chemical molluscicides to control GAS because it is non-toxic, environmentally friendly and cost-effective. This study is aimed to investigate the molluscicidal activity of an entomopathogenic fungus, Metarhizium anisopliae towards GAS adults and eggs. M. anisopliae conidia were subsequently produced into four concentrations (3×104, 3×105, 3×106, and 3×107 conidia/mL) and tested against adults and eggs GAS. The median lethal time (LT50) for the concentration of 3×107 took 5 and 3 days to kill 50% of GAS adults and inhibited 50% of eggs from hatching, respectively. Physiological analysis was also conducted on both GAS adults and eggs. The skin of infected individuals became white and opaque, while internal organs such as the pulmonary sac, digestive tract, and hepatopancreas were visibly destroyed. The colour of GAS eggs turned pale after M. anisopliaeinfestation and resulted in non-viable eggs. This research shows that M. anisopliae is an effective biological control agent for GAS and has the potential to be used as a targeted bio-molluscicide for GAS management.
Development of Semolina Starch/Agar-Based Intelligent Films by Incorporating Butterfly Pea Flower Anthocyanins to Monitor the Freshness of Prawns
Authors: Saravanan Srisanthiya , Abdullah Nor Adilah , Hasanah Nur Nabilah , Mohamad Azman Ezzat , Zainal Abedin Nur Hanani , Mohammad Rashedi Ismail-Fitry
Published: February 2024

The natural plant-derived pH indicator film which monitors food freshness during storage has gained attention among researchers due to consumer awareness of food quality, freshness, and food safety. This study aims to develop a semolina/agar-based film (S/A) incorporated with anthocyanins from butterfly pea flower extract (BPE) as a freshness indicator for tiger prawns and freshwater prawn during 4 days of storage at 4±1 °C. The semolina/agar-based butterfly pea extract (S/A/BPE) films were developed with different concentrations of BPE (3, 6, and 9%) by casting method. Increasing BPE up to 9% in the S/A film increased the thickness and moisture content, lowering the films’ water permeability. The film also had a smoother surface structure with a darker colour. Different pH solutions (pH 2.0-12.0) also changed the colour of films, depending on the BPE concentrations. The application of S/A/BPE films on tiger prawns and freshwater prawns caused colour changes from dark blue at day 0 (fresh stage) to intense green at day 2 (beginning of spoilage) indicating the spoilage of samples. The pH values of both prawns were gradually increased. However, no major changes were observed in the texture profile analysis. These results indicate that S/A/BPE film has the potential to be used as a pH indicator film to detect the freshness of prawn samples.
Physicochemical, Microbiological and Organoleptic Properties of Cowpeas (Vigna Unguiculata) Yoghurt with The Addition of Gotu Kola Leaf (Centella Asiatica (L.) Urban) Extract
Authors: Kumalasari Ika Dyah , Fathiyya Lubna Nur , Septiyani Retnosyari
Published: February 2024

Cowpea yogurt is a functional food product made from cowpeas and gotu kola leaves. This mixture of cowpeas and gotu kola leaves is expected to increase its functional value i.e., protein and antioxidant activity. This research aims to analyze the physicochemical, microbiological, and organoleptic properties of cowpeas yogurt with the addition of gotu kola leaf extract. The study used a Completely Randomized Design (CRD) with one factor, with the ratio of cowpea’s milk: gotu kola leaf extract, namely F1 (98%: 2%), F2 (96%: 4%), F3 (94%: 6%), K2 (100%: 0%), and K1 (100% pure milk). Testing parameters include viscosity, pH value, (moisture, ash, fat, protein, carbohydrate) content, antioxidant activity, total lactic acid bacteria, and organoleptic (color, aroma, taste, texture). The results showed that the highest pH and viscosity values in K2 were 3.77 and 419.59 cP; the highest moisture content in F3 was 85.04%; the highest ash, fat, and carbohydrate content in K2 were 0.62%, 1.87%, and 10.21%; the highest protein content in F1 was 3.25%; the highest antioxidant activity in F3 with an IC50 value of 87.008 ppm; the total lactic acid bacteria in K2 met the minimum SNI requirements of 107 CFU/mL; and K2 showed the most favorable overall organoleptic test. This study shows that the addition of gotu kola leaf extract affects on the physicochemical, microbiological, and organoleptic properties of cowpea yogurt.
Fabrication of Adsorbent Using Nano-Sized Lignocellulosic Biochar Coated on Luffa Aegyptiaca Sponge to Remove Heavy Metal Chromium VI
Authors: Yulia Elfi , Purwasasmita Bambang Sunendar , Nugraha Nugraha , Ekawati Estiyanti , Nugraha Ashari Budi
Published: February 2024

Eliminating heavy metal Cr (VI) in liquids is challenging. Developing adsorbents using sustainable, cheap, and biodegradable materials is still a concern. Therefore, this study aims to synthesize a heavy metal adsorbent by transforming forest residue into nano-sized lignocellulose biochar. This nano-sized lignocellulosic biochar, with the assistance of chitosan and alginate, was coated onto the Luffa aegyptiaca sponge surface to complete the structure of the proposed heavy metal adsorbent. This adsorbent is easy to apply in adsorbing heavy metals, is durable, and can be reused. The adsorbent products were characterized to observe the functional groups by Fourier Transform Infrared (FTIR) and surface morphology by Scanning Electron Microscopy (SEM). The adsorbents were also experimented with contact times of 120 and 1200 minutes in the adsorption process. The decrease in heavy metal concentration was analyzed by Atomic Absorption Spectroscopy (AAS). Scanning Electron Microscopy with Energy Dispersive X-ray spectroscopy (SEM-EDX) observed the adsorbent surface that has absorbed heavy metal ions. FTIR characterization of surface functional groups showed the presence of hydrogen, aliphatic C-H group, C=C aromatic ring, carboxyl groups, and carbonate ion, capable of binding heavy metal Cr (VI). The morphology of the adsorbent coated on luffa showed that the adsorbent was well attached. The results of the adsorption process showed a decrease in Cr (VI) concentration, with adsorption efficiency reaching 94% for 1200 min and adsorption capacity of 0.36 mg/g. SEM-EDX results validated the attachment of Cr (VI) heavy metal ions to the adsorbent surface.
Stability and Safety Analysis of Statin-Loaded Nano-films for the Treatment of Diabetic Wound
Authors: Rasool Maria , Alotaibi Nawaf M. , Sarfraz Muhammad , Siddique Muhammad Irfan
Published: February 2024

Diabetes mellitus (DM) is a metabolic disease that delays the regular stages of the wound's healing process due to delayed inflammatory stages. Due to foot pressure points, chronic foot wounds are ultimately considered the primary cause of lower leg amputation. Diabetic patients have vascular dysfunction and neuropathy, leading to inadequate oxygen supply to the wound area. Statins have a crucial role in the regulation of angiogenesis that could increase vascular endothelial growth factor (VEGF) synthesis. By offering a localized treatment approach while minimizing systemic side effects associated with oral medication, this study aimed to develop statin-loaded nanofilms to determine their stability and safety among healthy individuals as a potential procedure for diabetic wound healing. Simvastatin (SIM) loaded nanofilms formulations (F1-F10) were prepared using the solvent casting method. The formulation was optimized based on tests such as physical appearance, tensile strength, microscopic photographs, morphology, and drug content uniformity. ICH guidelines were followed to determine various parameters (physical appearances, tensile strength, microscopic photographs, morphology, and drug content uniformity) for six-month stability study at three different storage conditions. Safety analysis of the nanofilms was performed on healthy human skin using the Draize skin irritation test. Results showed F7 formulation was considered an optimized formulation as well as stable through the storage period at 4 ± 2°C, 25 ± 2°C, and 40 ± 2 °C. Furthermore, Primary Irritation Index results (PII was 0 showed no irritation in case and control groups) indicate its safety and biocompatibility to skin. Thus, the optimized statin-loaded nanofilm is stable, safe, and non-toxic, which may be used as a potential diabetic wound healing agent.
Brain neurotrophic factor BDNF: new data, functions and questions
Authors: Zhivkovich Maryana , Ermolaeva Elizaveta V. , Soboleva Alesya V. , Samoilova Ekaterina M. , Chudakova Daria A. , Baklaushev Vladimir P.
Published: February 2024

The brain-derived neurotrophic factor (BDNF) is a key modulator of neurogenesis, synaptogenesis, neuroregeneration, and cell differentiation in the nervous system. Impaired BDNF functioning is a characteristic of various neurological diseases, such as Alzheimer’s disease, multiple sclerosis, and depressive disorders. There is recent evidence that patients with COVID-19 have reduced BDNF levels in the blood plasma. Furthermore, exogenous BDNF and its mimetics have demonstrated therapeutic potential.
In this review, we systematized data of the BDNF gene structure, epigenetic and microRNA-mediated regulation of its expression, transcriptional variants of BDNF, and the effects of BDNF on neuronal and oligodendroglial differentiation. Further, we point out the gaps in the current knowledge about BDNF and propose experiments that can expand such knowledge and the range of possibilities for using BDNF in biomedicine. These include determining the expression pattern of all BDNF gene transcripts at different stages of differentiation and in different cell subpopulations and studying the role of receptor-independent BDNF signaling, circadian fluctuations in BDNF levels, and their role in physiological and pathophysiological conditions. Finally, for translational medicine, evaluating the effect of BDNF mimetics (including those immobilized on three-dimensional scaffolds for tissue engineering) on neuronal and oligodendroglial differentiation of pluripotent and polypotent cells and identifying molecular regulators of BDNF transcription, including small molecules and microRNAs capable of regulating BDNF gene expression, are crucial.
Functional and Spatial Optimization of the Protected and Ecological Networks of Ternopil Region in Ukraine
Authors: Tsaryk Lyubomir , Tsaryk Petro , Yankovska Liubov , Novytska Svitlana , Tsaryk Volodymyr
Published: February 2024

The article examines the essence of the European Strategy for the Conservation of Landscape and Biotic Diversity, the principles of formation, conservation and use of eco-networks in Ukraine, the existing problems of national and regional networks, taking into account the new administrative territorial structure at the administrative-district level and the level of territorial communities. The purpose of the article is to assess the functional and territorial structure of the protected and ecological networks of Ternopil region and to substantiate the ways of their optimization in modern conditions. The paper is based on the information obtained in the course of field expeditionary research in 2019–2022, as well as on statistical data, cartographic materials, and materials from the open network of aerospace satellite images Google Earth. The collected materials were processed using a system of methods (analysis, synthesis, comparison, decoding, cartographic, computer modeling, etc.). The data obtained showed that in 36.5% of the territorial communities, protected areas cover less than 1%. In order to improve the situation, the authors propose the creation of 53 new protected areas in 25 communities of Ternopil region with a total area of 39,358 hectares and substantiate the new core and connecting territories of the local rank of the regional eco-network.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia in adults
Authors: Baimakanova G. E. , Kirichenko N. D. , Karnaukhov N. S. , Kolyago E. M. , Brodskaya O. N. , Butyugina I. N. , Gripas D. Yu. , Ukolova S. K.
Published: February 2024

Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) is an understudied rare disease that should be taken into account in the differential diagnosis of therapy-resistant bronchial obstruction combined with focal pulmonary lesions and mosaic attenuation on chest CT. The aim of this article is to discuss the aspects of clinical and morphological diagnosis, therapeutic options, prognosis assessment, and the need for follow-up using a clinical case as an example. The article describes a clinical case of DIPNECH in a 55-year-old woman, and also provides a brief review of the scientific literature on DIPNECH. DIPNECH is a rare disease that most often affects non-smoking women aged around 60 years. The most frequent clinical manifestations are cough, dyspnea, stridor, and broncho-obstructive syndrome. Only histological and immunohistochemical assays can confirm the diagnosis. DIPNECH should be considered as part of the differential diagnosis in patients with prolonged cough, dyspnea of unclear genesis and changes on chest CT in the form of pulmonary focal lesions and mosaic attenuation. Conclusion. The presented clinical case shows the challenges and importance of timely diagnosis.
Posttraumatic stress symptoms during treatment in parents of children diagnosed with cancer
Authors: Sopori Varsha Mishra , Lingayat Aditi Maruti , Irfan Aziz Farookh
Published: February 2024

The study aimed to study the presence of PTSS in parents of children with cancer currently on treatment and the association of PTSS in parents with cancer during treatment with length of time since diagnosis and treatment intensity.

The study was conducted on 360 parents at a Tertiary Care Government Medical College and Cancer Hospital. The participants were subjected to the questionnaire PTSD Checklist Civilian Version (PCL-C) scale, to assess PTSS and Oncologists rated the intensity of each child's treatment.

The most common age group in the parents was of young adults 25-34years [255(71%)]. Majority of parents were male 288(80%). It was found that PTSD was present in majority of parents [235(65.27%]. On statistical analysis, no significant relationship was found between PTSS in mothers and fathers (p=0.1664). There was no significant relationship between PTSS and the length of time since diagnosis in both mothers (P=0.85) and fathers (P=0.32). No significant relationship was found between the intensity of treatment and PTSD in mothers on statistical analysis (p<0.3). While PTSD in fathers showed significant correlation with the intensity of treatment of the child (p<0.05).

There are very few studies regarding examining emotional distress of parents of children with malignancies in our country. Hence, studying PTSS in parents of children with cancer seems to be significant and more research needs to be done in this area.
TOPS score (T-temperature, O-Oxygen saturation, P- Perfusion, S- Sugar) on admission in transported neonates to tertiary care hospital
Authors: Roy Anna , Patel Priti , Ladumor Hitesh Mathurbhai , Gajjar Aditya Pravinkumar
Published: February 2024

In India, 70% of deliveries take place in rural areas and the transport of the preterm babies to a tertiary care centre are referred only after the birth Babies must be transported to a higher level neonatal intensive care unit (NICU) to overcome the negative effects of critical illness such as respiratory distress and asphyxia in newborns. Most of the neonates are transported without any pre-transport stabilization or care during transport, which can have serious clinical implications on the ultimate outcome of babies.

To assess the clinical condition and presence of complications among neonates transported to NICU. To predict outcome of transported neonates in terms of morbidity and mortality based on TOPS score.

A cross-sectional observational study was conducted among 500 newborns admitted in NICU, at New Civil Hospital, Surat.

Out of total, 258(51.3%) and 245(48.7%) patients were respectively males and females in the study. Out of the 503referred neonates 258 (51.3%) were referred for respiratory distress and ventillatory support, 138(27.4%) were referred for LBW / prematurity. The hypothermia was present post transport approximately among 64% neonates. Hypoglycaemia was found in only 18% of transported neonates. 33% of the studies neonates were hypoxic on reaching the referral centre and the remaining maintained spo2 above 90%.

The high sensitivity (81%) and high negative predictive value (87.4%) with a specificity of 61.5% and positive predictive value of 59.7% suggest that TOPS score a very strong screening test to predict the outcome of babies admitted.
Cutaneous metastasis in a case of carcinoma floor of mouth- A rare case report
Authors: Grover Romi Kant , Priya Sheenu , Garg Pardeep , Goyal Navik
Published: February 2024

The incidence of cutaneous metastasis in head and neck cancers is less than 1%. Carcinoma of the oral cavity is one of the most common cancers of the head neck region with frequent metastasis to internal organs, especially the lungs, liver, and bone.We present a case of Carcinoma of floor of mouth with cutaneous metastasis.

A 55 year old lady presented to our department with complaints of non-healing ulcer in the oral cavity and ulcerated nodules over neck and chest. On examination, mouth opening tongue mobility was restricted with grade 2 trismus. An ulcer in left gb sulcus, bilateral lymphadenopathy and multiple ulcerated skin nodules on neck and chest wall were noted. CECT Face and Neck showed heterogenously ehancing mass at the floor of mouth involving left buccal mucosa and erosion of mandible, lymph node mets and skin nodules. ECOGPS was 1.She was treated with palliative systemic chemotherapy and thereafter Palliative radiation. Now she is having stable disease and is on metronomic chemotherapy with regular follow up.

Our case has highlighted that cutaneous metastasis can be seen in the cancers of floor of mouth. Palliative chemotherapy and radiotherapy can significantly increase Progression free survival and hence the Quality of life of patients with such presentation.
Impacto de la conectividad digital en hogares liderados por mujeres, individuos de pueblos indígenas o afrodescendientes en Perú
Authors: Katz Raúl , Barrantes Roxana , Agüero Aileen , Valencia Ramiro , Burneo José , Soberón Alexandra , Duffó Ana , Callorda Fernando , Puig Gabarró Pau , García Zaballos Antonio , Iglesias Rodriguez Enrique , Dalio Maribel
Published: February 2024

El objetivo de este documento es presentar el efecto socioeconómico de las tecnologías digitales (uso de Internet o computadora y tenencia de celular) en Perú, abordando el análisis tanto desde un enfoque cuantitativo (modelo econométrico) como cualitativo (desarrollo de grupos focales). El análisis cuantitativo se centra en el impacto diferenciado del uso de tecnologías digitales en los ingresos y el empleo en individuos residentes de hogares liderados por hombres o mujeres, en individuos pertenecientes a pueblos indígenas y en individuos de etnia afrodescendiente. Asimismo, la investigación también mide el impacto de dichas tecnologías en subgrupos de las categorías precedentes desagregados por sexo, nivel educativo y zonas geográficas El análisis cualitativo se realiza con el fin de explorar las percepciones, las expectativas y los temores relacionados con el acceso, el uso y la apropiación de las tecnologías digitales en distintas regiones de Perú. En concreto, la investigación examinó el panorama de acceso, uso y apropiación de las tecnologías digitales en ocho grupos focales con hombres y mujeres que se autoidentifican como parte de los grupos étnicos quechua y asháninka en cuatro regiones de Perú (Lima, Cusco, Huancavelica y Pasco)
Brechas y oportunidades para la equidad de género en el sector minero energético peruano
Authors: Huapaya Nava Mario , Méndez Diana , Manrique Alejandra , Vallejo Elizabeth
Published: February 2024

Uno de los principales retos para el establecimiento de políticas públicas y agendas país para el cierre de brechas de género es contar con data fiable, oportuna y continua. El presente estudio busca analizar y compartir información sobre este aspecto, basada en datos y prácticas concretas de la actividad empresarial minero energética. A partir de dicha información, se espera establecer prioridades y una agenda de trabajo público-privada para el cierre de brechas sobre la participación de la mujer en dichos subsectores. A pesar de las brechas de participación de la mujer en el sector minero-energético, y las brechas de información asociadas, existen esfuerzos significativos realizados desde empresas comprometidas con un desarrollo inclusivo. Estos factores de éxito, habilitantes para el cierre de brechas, marcarán la ruta a seguir para la equidad de género en el sector. Por último, este estudio deja ver la necesidad de emprender esfuerzos adicionales para la construcción de un diagnóstico de brechas y oportunidades en el sector minero-energético que integre los aprendizajes de este primer ejercicio en una propuesta adaptada al contexto peruano, de la mano con aliados clave.
Guyana and the IDB Group: Partnering for Resilience
Authors:   Inter American Development Bank,   IDB Invest,   IDB Lab
Published: February 2024

The IDB Group has been collaborating with Guyana for 48 years and has been a key partner supporting the transformation of the country's economy and improving the lives of the Guyanese population. This publication showcases projects, main milestones, and highlights of these efforts.
Percepção de moradores da região metropolitana de Curitiba sobre o desempenho térmico de habitações condicionadas naturalmente nos períodos de outono e inverno
Authors: Moreira João Adolfo , Breda Fontão Pedro Augusto , Sorgato Márcio José , Fernandes Leandro Carlos
Published: February 2024

Este artigo apresenta a primeira etapa de uma pesquisa de longo prazo sobre percepção e desempenho térmico em edificações passivas na Região Metropolitana de Curitiba. Nesta etapa, o objetivo foi conhecer a percepção de uma amostra da população sobre a qualidade do ambiente térmico das suas habitações, condicionadas naturalmente, nos períodos de outono e inverno. Adicionalmente, buscou-se desenvolver e testar um protocolo para coleta de dados via internet para estudos com amostras mais amplas, para etapas futuras. Utilizando um questionário on-line, foram coletados dados subjetivos e objetivos, registrados pelos participantes. Paralelamente, foram monitoradas a temperatura do ar e a umidade relativa externa, registradas por estação meteorológica. Como resultado da análise dos dados obtidos, concluiu-se que a maior parte (dois terços) da amostra pesquisada possui uma percepção negativa quanto ao desempenho térmico das suas moradias no período de inverno. Os votos indicaram o predomínio da sensação de frio, embora também tenham indicado certa tolerância a essa sensação. Ainda que esta etapa da pesquisa tenha tido caráter exploratório, apresentou um panorama consistente a respeito da percepção dos moradores quanto ao desempenho térmico das moradias da região, validou a estratégia utilizada e apontou caminhos para seu aprimoramento e aplicação em uma escala mais abrangente.
Panorama brasileiro das certificações ambientais na construção civil
Authors: Dias Raquel Pedroso , Oliveira Cássio Gomes de , Punhangui Katia Regina Garcia , Possan Edna
Published: February 2024

O presente estudo objetiva analisar o panorama brasileiro de certificações ambientais no setor da construção civil em relação a representatividade do LEED, AQUA-HQE, BREEAM e Selo Casa Azul no total de certificações emitidas, avaliando-se também a distribuição geográfica, classificação dos empreendimentos, nível dos selos e ano de obtenção. O método consiste em uma revisão da literatura com abordagem quantitativa e em um levantamento de dados primários junto às bases de dados online dos sistemas de certificação. Constatou-se que até julho de 2021, o panorama brasileiro era composto por 1130 certificações ambientais emitidas e válidas, com o LEED liderando a quantidade de empreendimentos certificados (62,48%), seguido pelo AQUA-HQE (31,50%), Selo Casa Azul Caixa (5,75%) e BREEAM (0,27%). Estes empreendimentos são em sua maioria comerciais/corporativos (45,58%) ou residenciais (20,35%). Quanto ao nível da certificação, tanto o Selo Casa Azul Caixa e o LEED apresentam predominância do nível ouro, com 55% e 41%, com uma provável explicação mercadológica. Dessa maneira, contata-se que no Brasil houve difusão das certificações ambientais na última década, mas que ainda são necessários estudos voltados a análise do ciclo de vida com o objetivo de mensurar a efetividade das soluções sustentáveis adotadas.
Mobilidade em Regiões Metropolitanas (RM’s), um estudo de caso aplicado à cidade de Salvador e RM, Bahia, Brasil
Authors: Lopes Kaíc Fernando Ferreira , Rossetto Adriana Marques , Fernandes Rosali Braga
Published: February 2024

O objetivo deste artigo é destacar aspectos da mobilidade da Região Metropolitana de Salvador (RMS), relacionando-os com informações socioeconômicas da população. Assim, o estudo utilizou dados da Pesquisa de Origem e Destino (O/D)do Governo da Bahia, verificando a característica das viagens e padrões de deslocamento na RM. É possível observar por exemplo, que as mulheres andam menos de transporte individual motorizado (48,5%) enquanto o gênero masculino perfaz 51,5% das viagens. Também identifica-se um percentual significativo (36,2%) de transporte não motorizado (a pé) sendo que nesta categoria aumenta a utilização a medida em que reduz o indicador de renda. Este resultado também é encontrado em relação ao transporte público, entretanto, em relação ao transporte individual motorizado se observa o contrário, sendo que sua utilização aumenta e função do aumento da renda. No conjunto das viagens predominam as com destino a Salvador em um padrão de fluxo pendular casa-trabalho/estudo.
Paisagens da produção: memórias em disputa no território metropolitano de Campinas
Authors: Schicchi Maria Cristina da Silva
Published: February 2024

Estudando as cidades médias e pequenas da Região Metropolitana de Campinas (RMC), no território definido indistintamente como periferia, revelaram-se contornos específicos: o periurbano e o suburbano, onde novas e tradicionais práticas sociais se entrelaçam. Os resultados da pesquisa confirmaram a hipótese de que a compreensão de conjuntos de cidades alinhadas por vetores de expansão metropolitana permitiria novas perspectivas para a discussão dos “patrimônios dispersos” da região. A heterogeneidade do território formado por cada vetor tornou-se uma característica importante - tema comum a outras regiões metropolitanas do país - com aspectos compartilhados (história, referências culturais, festas e festivais), conformações espaciais similares (subcentralidades, vazios, condomínios fechados, assentamentos, bairros rurais), formação sociocultural semelhante (imigrantes, comunidade negra, migrantes, refugiados, sitiantes) e uma mesma lógica de inter-relação induzida por eixos históricos de estruturação do território, como rios, ferrovias e caminhos. Partindo de uma base teórico-metodológica própria, procurou-se mapear as inter-relações socioculturais e suas projeções no território da RMC, com especial atenção às paisagens formadas a partir dos sucessivos ciclos socioeconômicos regionais vinculados à implementação dos eixos ferroviários. O entendimento dos patrimônios dispersos no território como parte dessas “paisagens menores” formadas sob a mesma base histórico-cultural, exigiu uma nova interpretação do conjunto de remanescentes como paisagens históricas da produção. Este artigo apresenta os resultados do estudo de dois dos vetores de conformação do território da RMC, com recorte temporal a partir do final do século XIX, quando se conformaram os primeiros núcleos de fixação de operários, com a criação dos núcleos coloniais. O método adotado foi o histórico-crítico, com pesquisa bibliográfica e documental; empírico, com estudos de campo e cruzamento de dados (mapeamentos, gráficos, fotografias, legislação) e entrevistas com agentes, gestores e representantes de grupos locais. Concluiu-se que é necessária uma revisão das atuais unidades de gestão territorial e dos instrumentos de preservação existentes, em geral, voltados para a proteção de contextos homogêneos e contíguos, para que seja possível elaborar políticas culturais e patrimoniais em nível regional.