bluuebunny/crossref_metadata_2025 huggingface dataset:
A Cost–Benefit Analysis of COVID-19 Vaccination in Catalonia
Authors: López Francesc , Català Martí , Prats Clara , Estrada Oriol , Oliva Irene , Prat Núria , Isnard Mar , Vallès Roser , Vilar Marc , Clotet Bonaventura , Argimon Josep Maria , Aran Anna , Ara Jordi
Published: January 2022

(1) Background: In epidemiological terms, it has been possible to calculate the savings in health resources and the reduction in the health effects of COVID vaccines. Conducting an economic evaluation, some studies have estimated its cost-effectiveness; the vaccination shows highly favorable results, cost-saving in some cases. (2) Methods: Cost–benefit analysis of the vaccination campaign in the North Metropolitan Health Region (Catalonia). An epidemiological model based on observational data and before and after comparison is used. The information on the doses used and the assigned resources (conventional hospital beds, ICU, number of tests) was extracted from administrative data from the largest primary care provider in the region (Catalan Institute of Health). A distinction was made between the social perspective and the health system. (3) Results: the costs of vaccination are estimated at 137 million euros (€48.05/dose administered). This figure is significantly lower than the positive impacts of the vaccination campaign, which are estimated at 470 million euros (€164/dose administered). Of these, 18% corresponds to the reduction in ICU discharges, 16% to the reduction in conventional hospital discharges, 5% to the reduction in PCR tests and 1% to the reduction in RAT tests. The monetization of deaths and cases that avoid sequelae account for 53% and 5% of total savings, respectively. The benefit/cost ratio is estimated at 3.4 from a social perspective and 1.4 from a health system perspective. The social benefits of vaccination are estimated at €116.67 per vaccine dose (€19.93 from the perspective of the health system). (4) Conclusions: The mass vaccination campaign against COVID is cost-saving. From a social perspective, most of these savings come from the monetization of the reduction in mortality and cases with sequelae, although the intervention is equally widely cost-effective from the health system perspective thanks to the reduction in the use of resources. It is concluded that, from an economic perspective, the vaccination campaign has high social returns.
A New Epitope Selection Method: Application to Design a Multi-Valent Epitope Vaccine Targeting HRAS Oncogene in Squamous Cell Carcinoma
Authors: Savsani Kush , Jabbour Gabriel , Dakshanamurthy Sivanesan
Published: January 2022

We developed an epitope selection method for the design of MHC targeting peptide vaccines. The method utilizes predictions for several clinical checkpoint filters, including binding affinity, immunogenicity, antigenicity, half-life, toxicity, IFNγ release, and instability. The accuracy of the prediction tools for these filter variables was confirmed using experimental data obtained from the Immune Epitope Database (IEDB). We also developed a graphical user interface computational tool called ‘PCOptim’ to assess the success of an epitope filtration method. To validate the filtration methods, we used a large data set of experimentally determined, immunogenic SARS-CoV-2 epitopes, which were obtained from a meta-analysis. The validation process proved that placing filters on individual parameters was the most effective method to select top epitopes. For a proof-of-concept, we designed epitope-based vaccine candidates for squamous cell carcinoma, selected from the top mutated epitopes of the HRAS gene. By comparing the filtered epitopes to PCOptim’s output, we assessed the success of the epitope selection method. The top 15 mutations in squamous cell carcinoma resulted in 16 CD8 epitopes which passed the clinical checkpoints filters. Notably, the identified HRAS epitopes are the same as the clinical immunogenic HRAS epitope-based vaccine candidates identified by the previous studies. This indicates further validation of our filtration method. We expect a similar turn-around for the other designed HRAS epitopes as a vaccine candidate for squamous cell carcinoma. Furthermore, we obtained a world population coverage of 89.45% for the top MHC Class I epitopes and 98.55% population coverage in the absence of the IFNγ release clinical checkpoint filter. We also identified some of the predicted human epitopes to be strong binders to murine MHC molecules, which provides insight into studying their immunogenicity in preclinical models. Further investigation in murine models could warrant the application of these epitopes for treatment or prevention of squamous cell carcinoma.
Elucidating the 3D Structure of a Surface Membrane Antigen from Trypanosoma cruzi as a Serodiagnostic Biomarker of Chagas Disease
Authors: Di Pisa Flavio , De Benedetti Stefano , Fassi Enrico Mario Alessandro , Bombaci Mauro , Grifantini Renata , Musicò Angelo , Frigerio Roberto , Pontillo Angela , Rigo Cinzia , Abelli Sandra , Grande Romualdo , Zanchetta Nadia , Mileto Davide , Mancon Alessandro , Rizzo Alberto , Gori Alessandro , Cretich Marina , Colombo Giorgio , Bolognesi Martino , Gourlay Louise Jane
Published: January 2022

Chagas disease (CD) is a vector-borne parasitosis, caused by the protozoan parasite Trypanosoma cruzi, that affects millions of people worldwide. Although endemic in South America, CD is emerging throughout the world due to climate change and increased immigratory flux of infected people to non-endemic regions. Containing of the diffusion of CD is challenged by the asymptomatic nature of the disease in early infection stages and by the lack of a rapid and effective diagnostic test. With the aim of designing new serodiagnostic molecules to be implemented in a microarray-based diagnostic set-up for early screening of CD, herein, we report the recombinant production of the extracellular domain of a surface membrane antigen from T. cruzi (TcSMP) and confirm its ability to detect plasma antibodies from infected patients. Moreover, we describe its high-resolution (1.62 Å) crystal structure, to which in silico epitope predictions were applied in order to locate the most immunoreactive regions of TcSMP in order to guide the design of epitopes that may be used as an alternative to the full-length antigen for CD diagnosis. Two putative, linear epitopes, belonging to the same immunogenic region, were synthesized as free peptides, and their immunological properties were tested in vitro. Although both peptides were shown to adopt a structural conformation that allowed their recognition by polyclonal antibodies raised against the recombinant protein, they were not serodiagnostic for T. cruzi infections. Nevertheless, they represent good starting points for further iterative structure-based (re)design cycles.
Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines
Authors: Sølund Christina , Underwood Alexander P. , Fernandez-Antunez Carlota , Bollerup Signe , Mikkelsen Lotte S. , Villadsen Signe Lysemose , Fahnøe Ulrik , Winckelmann Anni Assing , Feng Shan , Nørløv Vinten Caroline A. , Dalegaard Magnus Illum , Vizgirda Greta , Sørensen Anna-Louise , Ramirez Santseharay , Bukh Jens , Weis Nina
Published: January 2022

With increasing numbers of vaccine-breakthrough infections worldwide, assessing the immunogenicity of vaccinated health-care workers that are frequently exposed to SARS-CoV-2-infected individuals is important. In this study, neutralization titers against SARS-CoV-2 were assessed one month after completed prime-boost vaccine regimens in health-care workers vaccinated with either mRNA–mRNA (Comirnaty®, BioNTech-Pfzier, Mainz, Germany/New York, NY, USA, n = 98) or vector-based (Vaxzevria®, Oxford-AstraZeneca, Cambridge, UK) followed by mRNA-based (Comirnaty® or Spikevax®, Moderna, Cambridge, MA, USA) vaccines (n = 16). Vaccine-induced neutralization titers were compared to time-matched, unvaccinated individuals that were infected with SARS-CoV-2 and presented with mild symptoms (n = 38). Significantly higher neutralizing titers were found in both the mRNA–mRNA (ID50: 2525, IQR: 1667–4313) and vector–mRNA (ID50: 4978, IQR: 3364–7508) prime-boost vaccine regimens when compared to SARS-CoV-2 infection (ID50: 401, IQR: 271–792) (p < 0.0001). However, infection with SARS-CoV-2 induced higher titers when compared to a single dose of Vaxzevria® (p = 0.0072). Between mRNA–mRNA and vector–mRNA prime-boost regimens, the vector–mRNA vaccine regimen induced higher neutralization titers (p = 0.0054). Demographically, both age and time between vaccination doses were associated with vaccine-induced neutralization titers (p = 0.02 and p = 0.03, respectively). This warrants further investigation into the optimal time to administer booster vaccination for optimized induction of neutralizing responses. Although anecdotal (n = 3), those with exposure to SARS-CoV-2, either before or after vaccination, demonstrated superior neutralizing titers, which is suggestive of further boosting through viral exposure.
Influences on Pregnant Women’s and Health Care Professionals’ Behaviour Regarding Maternal Vaccinations: A Qualitative Interview Study
Authors: Gauld Natalie , Martin Samuel , Sinclair Owen , Petousis-Harris Helen , Dumble Felicity , Grant Cameron C.
Published: January 2022

The uptake of maternal influenza and pertussis vaccinations is often suboptimal. This study explores the factors influencing pregnant women’s and health care professionals’ (HCPs) behaviour regarding maternal vaccinations (MVs). Pregnant/recently pregnant women, midwives, pharmacists and general practice staff in Waikato, New Zealand, were interviewed. The analysis used the behaviour change wheel model. Interviews of 18 women and 35 HCPs revealed knowledge about MVs varied with knowledge deficiencies hindering the uptake, particularly for influenza vaccination. HCPs, especially midwives, were key in raising women’s awareness of MVs. Experience with vaccinating, hospital work (for midwives) and training increased HCPs’ knowledge and proactivity about MVs. A “woman’s choice” philosophy saw midwives typically encouraging women to seek information and make their own decision. Women’s decisions were generally based on knowledge, beliefs, HCPs’ emphasis and their perceived risk, with little apparent influence from friends, family, or online or promotional material. General practice’s concentration on children’s vaccination and minimal antenatal contact limited proactivity with MVs. Busyness and prioritisation appeared to affect HCPs’ proactivity. Multi-pronged interventions targeting HCPs and pregnant women and increasing MV access are needed. All HCPs seeing pregnant women should be well-informed about MVs, including how to identify and address women’s questions or concerns about MVs to optimise uptake.
What Determines Vaccine Hesitancy: Recommendations from Childhood Vaccine Hesitancy to Address COVID-19 Vaccine Hesitancy
Authors: Rodrigues Farren , Block Suzanne , Sood Suruchi
Published: January 2022

Vaccine hesitancy is a prevalent and ongoing issue. However, due to the COVID-19 pandemic, additional attention has been brought to the topic of vaccine hesitancy. Vaccine hesitancy is a threat to the population’s health globally. This article aims to acquire insights from previous literature to determine what works to increase vaccine uptake and how we can apply this knowledge to increase COVID-19 vaccine uptake. Research has focused chiefly on childhood vaccination and the hesitancy of caregivers. After conducting an extensive literature review, we have created a conceptual model of indicators that influence vaccine uptake for health providers and caregivers, which can also be used for vaccine recipients. Overall, the reasons for vaccine hesitancy are complex; therefore, a multifaceted approach is needed to address it. Understanding the factors that affect vaccine hesitancy will aid in addressing hesitancy and, in turn, lead to an increase in vaccine uptake.
Seroprevalence Study of Pertussis in Adults at Childbearing Age and Young Infants Reveals the Necessity of Booster Immunizations in Adults in China
Authors: Chen Zhiyun , Pang Jie , Zhang Nan , Chen Ning , Ding Yiwei , He Qiushui
Published: January 2022

In China, the vaccination strategy against pertussis is started from 3 months of age, with no booster dose used after the booster given at two years. Despite a high vaccination coverage, pertussis has been increasingly reported since the last decade. This study evaluates the prevalence of serum anti-pertussis toxin (PT) IgG antibodies in adults at childbearing age and infants before the age of primary immunization in Beijing, China. A total of 1175 serum samples randomly selected from individuals who attended an annual health examination at the Sixth Medical Center of the PLA General Hospital, Beijing, in 2019, was included. The geometric mean concentration (GMC) and median concentration of anti-PT IgG antibodies among adults aged 20–39 years were 3.81 IU/mL and 3.24 IU/mL, and the corresponding concentrations were 1.72 IU/mL and 1.43 IU/mL among infants under 3 months of age. The seroprevalence of PT IgG antibodies ≥ 40 IU/mL in adults and infants was 2.0% (15/735) and 1.1% (5/440). In total, 65.99% (485/735) of adults and 83.41% (367/440) of infants had non-detectable pertussis-specific antibodies (<5 IU/mL). Our results showed that the majority of adults at a reproductive age and young infants are vulnerable to pertussis, suggesting that booster vaccinations in adults should be considered in this country.
Acceptance of a Third Dose of COVID-19 Vaccine and Associated Factors in China Based on Health Belief Model: A National Cross-Sectional Study
Authors: Qin Chenyuan , Wang Ruitong , Tao Liyuan , Liu Min , Liu Jue
Published: January 2022

COVID-19 infections are returning to many countries because of the emergence of variants or declining antibody levels provided by vaccines. An additional dose of vaccination is recommended to be a considerable supplementary intervention. We aim to explore public acceptance of the third dose of the COVID-19 vaccine and related influencing factors in China. This nationwide cross-sectional study was conducted in the general population among 31 provinces in November, 2021. We collected information on basic characteristics, vaccination knowledge and attitudes, and vaccine-related health beliefs of the participants. Univariable and multivariable logistic regression models were used to assess factors associated with the acceptance of a third COVID-19 vaccine. A total of 93.7% (95% CI: 92.9–94.6%) of 3119 Chinese residents were willing to receive a third dose of the COVID-19 vaccine. Individuals with low level of perceived susceptibility, perceived benefit, cues to action cues, and high level of perceived barriers, old age, low educational level, low monthly household income, and low knowledge score on COVID-19 were less likely to have the acceptance of a third dose of COVID-19 (all p < 0.05). In the multivariable logistic regression model, acceptance of the third dose of COVID-19 vaccine was mainly related to previous vaccination history [Sinopharm BBIP (aOR = 6.55, 95% CI 3.30–12.98), Sinovac (aOR = 5.22, 95% CI:2.72–10.02), Convidecia (aOR = 5.80, 95% CI: 2.04–16.48)], high level of perceived susceptibility (aOR = 2.48, 95% CI: 1.48–4.31) and high level of action cues (aOR = 23.66, 95% CI: 9.97–56.23). Overall, residents in China showed a high willingness to accept the third dose of COVID-19 vaccines, which can help vaccine manufacturers in China to manage the vaccine production and distribution for the huge domestic and international vaccine demand. Relevant institutions could increase people’s willingness to booster shots by increasing initial COVID-19 vaccination rates, public’s perception of COVID-19 susceptibility and cues to action through various strategies and channels. Meanwhile, it also has certain reference significance for other countries to formulate vaccine promotion strategies.
Microendoscopic Dorsal Laminectomy for Multi-Level Cervical Intervertebral Disc Protrusions in Dogs
Authors: Kamishina Hiroaki , Nakano Yukiko , Nakata Kohei , Kimura Shintaro , Nozue Yuta , Drury Adam G. , Maeda Sadatoshi
Published: January 2022

The objective of this study was to evaluate the feasibility and clinical outcomes of microendoscopic dorsal laminectomy for multi-level cervical intervertebral disc protrusions in dogs. Eight client-owned dogs diagnosed with multi-level cervical intervertebral disc protrusions using computed tomography (CT) and magnetic resonance imaging (MRI) were included in this retrospective case series. Microendoscopic dorsal laminectomies (MEL) were performed with an integrated endoscopic system to the cranial and caudal vertebrae of the affected intervertebral joints. Pre- and post-operative neurological status, operation time, intra-operative complications, and postoperative complications were reviewed. Post-operative CT images were obtained to measure the dimensions of laminectomy and compared to those of planned laminectomy. Full endoscopic procedures were feasible in 7 dogs (87.5%) and the laminectomy dimensions were in agreement with pre-operative planning. In all dogs, major intra- and postoperative complications did not occur. Conversion to open surgery was required in one case. Short-term postoperative clinical deterioration was found in two dogs. Long-term clinical outcomes were good and comparable to those reported in previous studies of open dorsal laminectomies. MEL is a promising minimally invasive approach to multi-level cervical dorsal laminectomy for intervertebral disc protrusions. This technique may improve postoperative discomfort compared to the open approach. Further studies are needed to directly compare outcomes between these two approaches.
Prevalence of Microsporum canis from Pet Cats in Small Animal Hospitals, Chiang Mai, Thailand
Authors: Chupia Vena , Ninsuwon Jirapat , Piyarungsri Kakanang , Sodarat Chollada , Prachasilchai Worapat , Suriyasathaporn Witaya , Pikulkaew Surachai
Published: January 2022

Dermatophytosis is a disease caused by dermatophytes, a group of fungi that can cause disease both in humans and animals. The important genera that are pathogenic in animals include Trichophyton and Microsporum. Microsporum canis is an important species because it can cause zoonosis and is commonly found in domestic animals. Cats, which live very close to humans, may expose humans to this pathogen. This research focused on the epidemiology of M. canis found in cats. Hair samples were collected via the Mackenzie technique from cats with and without skin lesions, preliminarily examined with 10% KOH preparation, and cultured for fungal identification. Samples were confirmed with molecular techniques including polymerase chain reaction, gel electrophoresis, and sequencing. Samples were collected from 138 cats located in 93 households, 43 from cats with skin lesions (31.16%) and 95 from cats without skin lesions (68.84%). Eighteen cats with lesions (13.04%) and ten cats without lesions (7.2%) were found to carry M. canis. In eleven of the eighteen cats both with skin lesions and positive for M. canis (61.11%), the pathogen was found both at the site of the lesion and at other sites in the body. Because the pathogen can be found in the hair of cats with and without skin lesions, owners, keepers, veterinarians, and others who come into contact with these animals are at risk of infection if they are not aware or do not take precautions after contact with them.
THE USE OF NANOTECHNOLOGY FOR THE DESIGN OF BUILDING STRUCTURES
Authors: Zhuykov S.
Published: January 2022

Russia has a developed industry of building materials, which today implements an energy- and resource-saving model of its development. The implementation of the state policy of resource conservation is carried out in two main directions: the first direction is to save resources in the production of materials, the second is to increase the production of energy–efficient materials that allow saving energy carriers during their operation. Modern construc-tion in Russia is guided by European construction standards, which, in turn, provides for the construction of ener-gy-saving buildings with minimal energy consumption from external sources. This is ensured by the use of struc-tural and thermal insulation materials in the construction of external walls. In modern structural and thermal insu-lation materials for energy-saving construction, high requirements are imposed on their thermal properties, me-chanical strength and comfort level. From the point of view of simultaneous satisfaction of these requirements, ceramic materials have obvious advantages over other materials, in particular cellular concretes, which, with al-most the same level of thermal conductivity, are characterized by the least hygroscopicity and significantly greater strength. An objective prospect for the development of structural and thermal insulation ceramics is the production of hollow ceramic stones with increased thermal efficiency for their use in economical single-layer external wall structures without additional insulation. The products of individual Ukrainian manufacturers and even imported analogues of the most famous European manufacturer (Wiernerberger Company, Austria), when used in single-layer walls, do not provide regulatory requirements for the heat transfer resistance of masonry for the first temper-ature zone of Russia, which occupies the majority of the territory (60%). This requires the improvement of domes-tic products in the direction of improving their thermal characteristics (reducing thermal conductivity and increas-ing thermal resistance).
INFLUENCE OF ANTI-HELMINTHIC TREATMENT ON THE PERFORMANCE AND TERMINATION OF CUTTING COWS SUPPLEMENTED ON GRASSLAND
Authors: de Sousa Osvaldo Alex , Cipriano Isabela de Almeida , de Favare Giordani Mascoli , do Carmo Tábata Alves , Guelpa Gabriel Jabismar , Bello Hornblenda Joaquina Silva , de Soutello Ricardo Velludo Gomes , Mena Mateus Oliveira
Published: January 2022

This work aimed to investigate the effect of anthelmintic treatment on the performance of cull cows. Sixty animals were evaluated, divided into three groups composed of 20 cows: two groups were treated with different anthelmintics (endectocide and conventional), while a control group received only saline solution. Anthelmintics and the saline solution will be administered subcutaneously at the doses recommended by the manufacturers: G1- Levamisol (RIPERCOL*L®) 1mL/40kg/PV; G2- Moxidectin (CYDECTIN®) 1mL/50kg/PV; G3- Control (saline solution) 1 mL/45kg/PV. Feces were collected to count eggs per gram of feces (OPG) of each animal, where a collection was every 28 days along with weighing to analyze the weight gain of the treatments. There was no statistical difference in OPG count and weight gain between the evaluated treatments. Both groups presented low contamination throughout the experiment, suggesting that when raised in comfortable conditions, healthy multiparous beef cows would not require anthelmintic treatment.
Hijrah Kaderisasi Aktivis Peneleh : Tandhim Sebagai Inovasi
Authors: Jaya Hendra , Setyaningrum Nensy
Published: January 2022

Abstrak

Penelitian ini mencoba untuk mengupas inovasi dan pola kaderisasi Aktivis Peneleh. Sekaligus menjadi tawaran hijrah kaderisasi berbasis nilai religiositas dan kebangsaan serta gerak aksi berbasis perlawanan (tandhim) bagi banyak organisasi. Data hasil penelitian dari berbagai sumber dianalisis secara deskriptif. Hasil penelitian menujukan keberhasilan kaderisasi Peneleh walau ditengah pandemi sekalipun. Hal tersebut didorong oleh banyak faktor, yang nantinya akan dipaparkan dalam artikel ini, terutama keseriusan dalam dakwah dan hijrah kaderisasi.
Partisipasi Publik Dalam Transparansi Penanganan Tindak Pidana Korupsi oleh KPK Melalui Pemanfaatan Media Elektronik
Authors: Rohman M. Saiful
Published: January 2022

Abstrak

Memperjuangkan pemberantasan tindak pidana korupsi tidak hanya menjadi kewajiban bagi lembaga penegak hukum tetapi juga seluruh masyarakat. Sebagai salah satu lembaga yang menangani tindak pidana korupsi di Indonesia Komisi Pemberantasan Korupsi mempunyai tugas dan wewenang dalam penyidikan, penyelidikan dan penuntutan. Namun dalam  hal kinerja KPK, masyarakat kurang mendapatkan informasi yang cukup. Sehingga publik kurang mengetahui akan sampai mana kasus tersebut berjalan. Dari sini dapat kita lihat bahwasanya publik belum bisa sepenuhnya mengawal KPK. Semestinya setiap langkah KPK dalam menangani kasus harus diinformasikan pada masyarakat luas. Hal itu untuk mengetahui perkembangan tersangka setelah menjadi terdakwa dan divonis apakah ia mengajukan banding atau bahkan ditingkat kasasi hingga ingkrahnya suatu kasus. Untuk itu KPK perlu memberikan informasi agar publik dapat mengawal kasus yang ditanganinya yaitu dengan memanfaatkan media elektronik sebagai sarana KPK untuk meyampaikan informasi pada publik.
La contaminación proveniente de la industria curtiembre, una aproximación a la realidad ecuatoriana
Authors: Silva María José , Salinas Morales Diego
Published: January 2022

El presente artículo se centró en describir los procesos típicos, materiales utilizados, principales riesgos para la salud derivados de la industria del curtido de pieles, así como el impacto ambiental asociado a dicha industria y actividad en la provincia de Tungurahua, Ecuador. Para el desarrollo del presente documento se realizó una revisión integradora de la literatura, como una modalidad de investigación bibliográfica. Como resultado principal se obtuvo que la contaminación de los afluentes hídricos, con químicos provenientes de las aguas residuales, producto de la transformación de las pieles animales en cuero para la industria de la marroquinería, ha determinado el crecimiento exponencial de la contaminación, debido a la deficiente gestión que se otorga a dichos residuos. La contaminación de los recursos hídricos se evidencia en la cantidad de cromo vertido en el agua, tanto de tipo trivalente, como hexavalente. La concentración de Cr6 va desde los 52.3 a los 392.9 mg/L, rebasando el límite que determina la normativa TULAS. Se concluye que la determinación de Cr6 se convierte en un potencial factor y un riesgo inminente para el desarrollo de las diferentes afectaciones asociadas a la exposición al cromo.
El proceso de aprendizaje virtual y su incidencia en la salud mental de los estudiantes
Authors: Toasa Guachi Lizbeth Aracely , Toasa Guachi Renato Mauricio
Published: January 2022

El proceso de aprendizaje y enseñanza evoluciona con el pasar del tiempo, debido a esto se implementan distintas metodologías y técnicas para que los estudiantes aprendan de manera óptima; sin embargo, una de las problemáticas más comunes dentro de la salud mental es el estrés y la ansiedad, que pueden generarse al no adaptarse a los nuevos sistemas en la educación, como lo es el caso del aprendizaje virtual obligado por la pandemia por COVID-19. En este contexto, la presente investigación busca describir la percepción de los estudiantes de octavo semestre de la carrera de psicología de la Universidad Tecnológica Indoamérica de la ciudad de Ambato, respecto a su experiencia de aprendizaje en entornos virtuales. Para ello, se recogen las percepciones de una muestra de 50 estudiantes de la Facultad de Ciencias Humanas y de la Salud, basándose en su experiencia con las clases bajo la modalidad virtual en tiempos de pandemia. Los resultados muestran que los estudiantes consideran que el estrés influye en su aprendizaje, y que suelen generar rasgos ansiosos al realizar tareas complejas. La solución hacia los problemas se direcciona al poder conocer los niveles de estrés y ansiedad que pueden tener los estudiantes, el docente influye mucho, por lo que él podrá utilizar metodologías interactivas e incorporar pausas activas, disminuyendo los niveles de estas patologías, con el fin de estimular las habilidades y capacidades de los alumnos.
Impacto de las tecnologías disruptivas en el proceso de enseñanza aprendizaje: caso UTM online.
Authors: Zambrano Romero Walter , Meza Hormaza Jaime Alcides
Published: January 2022

En la actualidad los entornos educativos en línea mediados por tecnologías han desarrollado ambientes de innovación en los procesos pedagógicos que facilitan el aprendizaje de los educandos, la presente investigación tiene como objeto de medir el impacto que tiene el uso de las tecnologías disruptivas en el proceso de enseñanza y aprendizaje de las carreras en línea de UTM online. Con el propósito de integrar estas innovaciones a los centros de Educación Superior, y de proveer nuevos mecanismos de construcción de significados. En cuanto al estudio, parte de una intencionalidad exploratoria, el enfoque utilizado en esta investigación fue de corte cuantitativo con un diseño no experimental y transversal, de alcance descriptivo, realizando un estudio del fenómeno comparado con otras asignaturas. Por otra parte, en los resultados se observa que el 80% de los participantes dieron una calificación correspondiente a totalmente satisfactorio. Lo que demuestra que los participantes perciben un mejor aprendizaje al implementar aplicaciones digitales y plataformas colaborativas en el desarrollo de prácticas en tiempo real discrepando inquietudes. La investigación sugiere que las herramientas digitales como Google Docs, Quizizz y Flipgrid son herramientas de aprendizaje útiles en su adaptación para fomentar la interacción y la retención del aprendizaje en línea.
The Practical Use of Online Comic Manga: Facilitating Students’ English Reading Engagement
Authors: Khusniyah Nurul Lailatul
Published: January 2022

The study was done to get the depth information from the practical use of online comic manga in building students’ English reading engagement. It creates the enjoy time to read and students get the meaningful activity in each reading process. The method used the one-group pretest-posttest experimental design. The data collected through observation, documentation and reading test. While data analysis used the t-test paired two samples for means. The resulting shows that t-stat (9.2934) t-table (2.0484), It means that reading online comic manga gave the fun activity at online class or home. The implication of the study was on the reading source learning to create enjoy and comfort learning.
Developing Interactive Electronic Book Based on TPACK to Increase Creative Thinking Skill
Authors: Siregar Budi Halomoan , Kairuddin Kairuddin , Mansyur Abil
Published: January 2022

This study aims to: (1) improve the creative thinking skills of prospective teachers, (2) measure the level of validity, practicality, and effectiveness of the developed electronic book. This type of research is research and development (RD) by applying the ADDIE model. This research was conducted through 5 stages: (1) analysis, (2) design, (3) development, (4) implementation, and (5) evaluation. The subjects of this study were students (prospective teachers) in the 5th-semester consisting of 55 people in the IT-based learning media course. At the same time, the object of this research was an electronic book developed based on TPACK. Several instruments were used: observation sheets, questionnaires, validation sheets, and essay tests. The results of data analysis indicate that the electronic book has met the requirements of validity, practicality, and effectiveness. In addition, there was a significant increase in the ability to think creatively.
Compensation and Work Discipline on Teachers’ Performance: A Multifactorial Design
Authors: Sihabudin Sihabudin
Published: January 2022

The purpose of this study is to measure the links between compensation and work disciplines towards the teachers’ performance. Underlying the concept of Human Resources Management (HRM) education, this study investigates the effect of the two aforementioned variables on the teacher’s pedagogical approach, classroom activities, and teaching strategies using technology. This research was conducted using a quantitative approach, specifically a multifactorial design. The sample of this current study was 53 people. The data was gathered through test and questionnaires. The data analysis used was a descriptive statistics and multiple linear regression analysis. The results showed that simultaneously the compensation and work discipline variables had a positive and significant effect on the teachers’ performance, and partially compensation and work discipline had a positive and significant effect on the teachers’ performance. The multiple linear regression equation is Y = 20.789 + 0.299X1 + 0.271X2. Meanwhile, the results of the descriptive analysis show that the variables of compensation, work discipline, and teachers’ performance are in a good criteria.
Analysis of Student Creativity in Developing Science Learning Media during the COVID-19 Pandemic
Authors: Wati Ulya , Hastuti Woro Sri , Mustadi Ali
Published: January 2022

This study aims to ascertain (1) the inventiveness of university students in developing digital media for science education. (2) provides an overview of elementary science media applications that students can develop, and (3) discusses the obstacles students encountered while developing digital media for elementary science learning during COVID-19. This study took place at Yogyakarta State University and Makassar State University. The sample size for this study is 142 students, including 71 UNM students and 71 UNY students. The approach is descriptive with a quantitative component. Thus, the results demonstrated students' creativity in developing science media during the COVID-19 pandemic, as measured by five characteristics: fluency, flexibility, originality, elaboration, and sensitivity. Students can create media by using applications such as PowerPoint, Articulate Storyline, Flipbook Maker, Wondershare Filmora, and a variety of other supporting platforms (websites). However, students face obstacles in four areas when developing media, including fluency, flexibility, originality, and elaboration, namely (1) students continue to struggle with integrating science learning media into elementary school through the use of appropriate approaches/models/learning methods, (2) determining the variety of problem-solving strategies available to users of science learning media in elementary school, and (3) determining the variety of problem-solving strategies available to users of science learning media in elementary school. (3) difficulty identifying science learning media for elementary schools located in areas without internet access due to the COVID-19 pandemic and others.
Interactive E-Module Development in Multimedia Learning
Authors: H Nurhikmah , Hakim Abdul , Wahid M. Syakir
Published: January 2022

This study aims to develop interactive e-modules in the Multimedia Learning Course and to know the validity, practicality of the effectiveness of developing interactive e-modules in Multimedia Learning subject. This research method used Research and Development (R D), which focused on developing smartphone-based learning media, especially Android. The development model used the Alessi and Trollip development model, consisting of 3 stages: planning, design, and development. This research was conducted at Makassar State University with 45 students and one lecturer in multimedia learning. Interactive e-modules are used in multimedia learning courses to assist and facilitate lecturers in the learning process. Interactive e-modules were developed and validated by material experts and media experts, with the results of material validation obtained an average score of 4.9 (very valid) and media experts obtained an average score of 4.1 (valid) so that interactive e-modules can be tested in the field to determine the practicality and effectiveness with the results shown in the category of very practical and very effective. Based on the results found, it can be concluded that interactive e-modules are practical and effective in the learning process in multimedia learning courses at the Education Technology Study Program, Makassar State University
Parenting Culture of Low-Income Families in Implications for the Subjective Well-being of Early Childhood Students
Authors: Wahyuni Sri , Putri Azlin Atika , Reswita Reswita
Published: January 2022

Poverty has a negative impact on parenting patterns that can reduce the subjective well-being) of childhood. This study aims to reveal the parenting skill of low-income families to improve the subjective well-being of childhood. This type of descriptive research with 119 parents in Pekanbaru comes from low-income families who live in  Pekanbaru. Results of the study revealed parenting skills respondents (41%) require information about good parenting to develop the potential of children for the child's positive development, the child's goodness, and independence. While 22% want their children to be successful and have a better future, they do not use the correct method, and 18% of respondents want their children to be more normative, more obedient, have good habits, and be accepted by society. About 14% of respondents want their children to achieve better academic performance, and 5% want their children to be happy and happy later. The conclusion is Parenting skills of low-income families in improving subjective well-being of early childhood is not optimal.
Data transfer in a decentralized network of robots using a local voting protocol
Authors: Amelin Konstantin , Ershov Vladislav
Published: January 2022

The construction of an effective intelligent information transmission system in a group of cyber-physical systems is one of the important problems in both practical and theoretical contexts. Such a system for transmitting information for a group is being built for a network consisting of separate robotic complexes. Increasingly, decentralized solutions are used to build effective interaction between group members. As a rule, in networks, decentralization is present in computing software modules, and the data transmission system between nodes is centralized. One of the aspects of such centralization is the need to send data to a specific destination directly or by relaying through other nodes - routing data in the network. In this work, a method of data transmission in a decentralized network between robotic complexes without reference to routing is proposed. The method consists of the exchange of data on the state of the entire network as a whole between the nodes.
Using of the SPSA method to improve the accuracy of the UAV following a given route under the action of wind loads
Authors: Amelin Konstantin , Maltsev Vladimir
Published: January 2022

In the modern world, UAVs (unmanned aerial vehicles) are increasingly used in everyday life in solving civilian tasks. One of the main applications of UAVs is data collection with their reference to a given coordinate system. For example, for the task of aerial photography, it is necessary to accurately link each image to the global coordinate system. In addition to the exact location of coordinates, it is worth the exact movement of a given route, to collect data of exactly those places that are needed. Thus, it is very important to ensure the minimum deviation of the UAV from the given route under the conditions of external disturbances (wind disturbances) acting on it. The article describes a procedure for assessing wind speed and direction for a UAV control system using the SPSA method. The simulation results of the algorithm operation, confirmed during flight tests on an ultralight UAV with an ardupilot autopilot, are presented.
On global trajectory tracking control of robot manipulators with a delayed feedback
Authors: Andreev Aleksandr , Peregudova Olga
Published: January 2022

In this paper, the trajectory tracking control problem of a robot manipulator with cylindrical joints is considered by means of a nonlinear PD controller taking into account the delayed feedback structure. The conclusion about stability of a closed-loop system is obtained on the basis of the development of the direct Lyapunov method in the study of the stability property for a non-autonomous functional differential equation by constructing a Lyapunov functional with a semi-definite time derivative.
Nonlinear repetitive control of the metal cutting machine feed module with saturated input
Authors: Eremin Eugenie L. , Nikiforova Larisa V. , Shelenok Evgeniy A.
Published: January 2022

The article discusses the methodology for constructing an automatic control system for the feed module of the cutting tool for lathes in the presence of input saturation. The presence of the saturation function is due to restrict unwanted movements of the feed module actuator. The generator for periodic signals, the hyperstability criterion, L-dissipativity conditions and an implicit reference model are used as the solution methods for structural synthesis of the control system. At the stage of simulation, the functioning quality of the developed control system is illustrated.
Control of vibrational field in an elastic vibration unit with DC motors and time-varying observer
Authors: Tomchina Olga P.
Published: January 2022

In the paper the problem of feedback control of vibrational fields in a vibration unit is analyzed taking into account the influence of the elasticity of cardan shafts, the drive dynamics, saturation for control torques. In addition, the synthesized rotor synchronization control algorithm uses the estimates of a non-stationary observer, which makes it possible to implement it practically on a two-rotor vibration unit SV-2. The performance of the closed loop mechatronic systems is examined by simulation for the model of the two-rotor vibration unit SV-2.
Teacher Careers in Education Systems That Are Coherent for Learning: Choose and Curate Toward Commitment to Capable and Committed Teachers (5Cs)
Authors: Hwa Yue-Yi , Pritchett Lant
Published: January 2022

How can education authorities and organisations develop empowered, highly respected, strongly performance-normed, contextually embedded teaching professionals who cultivate student learning? This challenge is particularly acute in many low- and middle-income education systems that have successfully expanded school enrolment but struggle to help children master even the basics of reading, writing, and arithmetic. In this primer, we synthesise research from a wide range of academic disciplines and country contexts, and we propose a set of principles for guiding the journey toward an empowered, effective teaching profession. We call these principles the 5Cs: choose and curate toward commitment to capable and committed teachers. These principles are rooted in the fact that teachers and their career structures are embedded in multi-level, multi-component systems that interact in complex ways. We also outline five premises for practice, each highlighting an area in which education authorities and organisations can change the typical status quo approach in order to apply the 5Cs and realise the vision of empowered teaching profession.
Developing a seq2seq neural network using visual attention to transform mathematical expressions from images to LaTeX.
Authors: Vyaznikov P. A. , Kotilevets I. D.
Published: January 2022

The paper presents the methods of development and the results of research on the effectiveness of the seq2seq neural network architecture using Visual Attention mechanism to solve the im2latex problem. The essence of the task is to create a neural network capable of converting an image with mathematical expressions into a similar expression in the LaTeX markup language. This problem belongs to the Image Captioning type: the neural network scans the image and, based on the extracted features, generates a description in natural language. The proposed solution uses the seq2seq architecture, which contains the Encoder and Decoder mechanisms, as well as Bahdanau Attention. A series of experiments was conducted on training and measuring the effectiveness of several neural network models.
Atom species energy dependence on magnetic configurations in the perovskite yttrium orthoferrite
Authors: Baglov A. V. , Khoroshko L S.
Published: January 2022

The article represents the results of studying of the influence of atom species in the perovskite multiferroic yttrium orthoferrite YFeO3 on magnetic configurations by ab-initio methods. Four magnetic configurations possible in magnetic sublattice that were formed by iron atoms were analyzed. It is shown that different magnetic orderings change the lattice parameters and the ions occupied positions while preserving symmetry of the unit cell, the lowest state responds G-AFM type magnetic ordering. The lattice parameters are in good relevant published experimental data. The atom species energy dependence shows that the main role in magnetic properties goes to iron and oxygen. In the ground state, magnetic properties relate with Dzyaloshinskii – Moriya interaction, while in other configurations, these relate with superexchange through Fe- O-Fe chains. Obtained results are useful for analyzing and designing straintronics devices. Also, the results can be interesting for interpretation and predicting magnetic properties of partially or fully substituted orthoferrites including substitution on rare-earth elements.
El método cualitativo y su aporte a la investigación en las ciencias sociales
Authors: Guzmán Víctor
Published: January 2022

El presente artículo de reflexión tiene como finalidad dar a conocer las características y bondades que tiene la investigación de corte cualitativo como herramienta clave para la implementación de investigaciones en el campo disciplinar de las ciencias sociales. Para lo cual se utiliza la metodología de enfoque documental, mediante la exploración de fuentes primarias y secundarias de información que permitan ahondar en la teoría y postulados claves, pretendiendo llegar al punto de tomar la argumentación de los autores más reconocidos en los parámetros de la metodología de la investigación. Como resultado podemos encontrar que la investigación cualitativa es un proceso fundamental con que cuenta el investigador para comprender la realidad presente en el contexto, por lo tanto, este paradigma extrae la esencia de las experiencias de las personas y expone los aspectos más arraigados.
Students’ Beliefs and Attitudes in Exploring Critical Literacy Comprehension towards Online Media Information into their Writing Practices
Authors: Riwayatiningsih Rika
Published: January 2022

Addressing critical literacy exploration into students’ language learning is perpetuated in this digital media- dependent environment. Reading and writing competencies have also pertained the critical enactment in order to present the beyond textual values. Through class discussions and class observations among 12 tertiary English major students in a private university in Indonesia, this study explores students’ beliefs and attitudes towards their critical literacy comprehension on online media information through writing practices. This exploratory case study collect the data covering the recordings of class discussions and class observations from student lesson implementation during their writing course. The results of this study reveal that most of the students are aware of the critical understanding of particular information conveyed from certain messages in their written works. Their beliefs on critical literacy agency has raised several attitudes of how they construct the social perspectives based on selections of what to include and exclude in their written texts. The article is also present recommendation to enlighten the learning in a critical stance.