bluuebunny/crossref_metadata_2025 huggingface dataset:
Severe Obesity Is an Independent Risk Factor of Early Readmission and Nonhome Discharge After Cervical Disc Replacement
Authors: Subramanian Tejas , Shinn Daniel , Shahi Pratyush , Akosman Izzet , Amen Troy , Maayan Omri , Zhao Eric , Araghi Kasra , Song Junho , Dalal Sidhant , Dowdell James , Iyer Sravisht , Qureshi Sheeraz
Published: September 2023

Objective: Despite growing interest in cervical disc replacement (CDR) for conditions such as cervical radiculopathy, limited data exists describing the impact of obesity on early postoperative outcomes and complications. These data are especially important as nearly half of the adult population in the United States is expected to become obese (body mass index [BMI] ≥ 30 kg/m2) by 2030. The goal of this study was to compare the demographics, perioperative variables, and complication rates following CDR.Methods: The 2005–2020 American College of Surgeons National Surgical Quality Improvement Program datasets were queried for patients who underwent primary 1- or 2-level CDR. Patients were divided into 3 cohorts: Nonobese (BMI: 18.5–29.9 kg/m2), Obese class-I (BMI: 30–34.9 kg/m2), Obese class-II/III (BMI ≥ 35 kg/m2). Morbidity was defined as the presence of any complication within 30 days postoperatively. Rates of 30-day readmission, reoperation, morbidity, individual complications, length of stay, frequency of nonhome discharge disposition were collected.Results: A total of 5,397 patients were included for analysis: 3,130 were nonobese, 1,348 were obese class I, and 919 were obese class II/III. There were more 2-level CDRs performed in the class II/III cohort compared to the nonobese group (25.7% vs. 21.5%, respectively; p < 0.05). Class-II/III had more nonhome discharges than class I and nonobese (2.1% vs. 0.5% vs. 0.7%, respectively; p < 0.001). Readmission rates differed as well (nonobese: 0.5%, class I: 1.1%, class II/III: 2.1%; p < 0.001) with pairwise significance between class II/II and nonobese. Class II/III obesity was an independent risk factor for both readmission (odds ratio [OR], 3.32; p = 0.002) and nonhome discharge (OR, 2.51; p = 0.02). Neither 30-day reoperation nor morbidity rates demonstrated significance. No mortalities were reported.Conclusion: Although obese class-II/III were risk factors for 30-day readmission and nonhome discharge, there was no significant difference in reoperation rates or morbidity. CDR procedures can continue to be safely preformed independent of obesity status.
Clinical Characteristics and Long-term Outcomes of Spinal Pilocytic Astrocytomas: A Multicenter Retrospective Study by the Neurospinal Society of Japan
Authors: Muto Jun , Murata Hidetoshi , Shigekawa Seiji , Mitsuhara Takafumi , Umebayashi Daisuke , Kanematsu Ryo , Joko Masahiro , Inoue Tatsushi , Inoue Tomoo , Endo Toshiki , Hirose Yuichi ,   for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Published: September 2023

Objective: The characteristics, imaging features, long-term surgical outcomes, and recurrence rates of primary spinal pilocytic astrocytomas (PAs) have not been clarified owing to their rarity and limited reports. Thus, this study aimed to analyze the clinical presentation, radiological features, pathological findings, and long-term outcomes of spinal PAs.Methods: Eighteen patients with spinal PAs who were surgically treated between 2009 and 2020 at 58 institutions were included in this retrospective multicenter study. Patient data, including demographics, radiographic features, treatment modalities, and long-term outcomes, were evaluated.Results: Among the 18 consecutive patients identified, 11 were women and 7 were men; the mean age at presentation was 31 years (3–73 years). Most PAs were located eccentrically, were solid or heterogeneous in appearance (cystic and solid), and had unclear margins. Gross total resection (GTR), subtotal resection (STR), partial resection (PR), and biopsy were performed in 28%, 33%, 33%, and 5% of cases, respectively. During a follow-up period of 65 ± 49 months, 4 patients developed a recurrence; however, the recurrence-free survival did not differ significantly between the GTR and non-GTR (STR, PR, and biopsy) groups.Conclusion: Primary spinal PAs are rare and present as eccentric and intermixed cystic and solid intramedullary cervical tumors. The imaging features of spinal PAs are nonspecific, and a definitive diagnosis requires pathological support. Surgical resection with prevention of neurological deterioration can serve as the first-line treatment; however, the resection rate does not affect recurrence-free survival. Investigation of relevant molecular biomarkers is required to elucidate the regrowth risk and prognostic factors.
Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up
Authors: Scheer Justin K. , Smith Justin S. , Passias Peter G. , Kim Han Jo , Bess Shay , Burton Douglas C. , Klineberg Eric O. , Lafage Virginie , Gupta Munish , Ames Christopher P. ,   The International Spine Study Group
Published: September 2023

Objective: The goal of this study was to determine if patients with mild scoliosis and age-appropriate sagittal alignment have favorable outcomes following surgical correction.Methods: Retrospective review of a prospective, multicenter adult spinal deformity database. Inclusion criteria: operative patients age ≥18 years, and preoperative pelvic tilt, mismatch between pelvic incidence and lumbar lordosis (PI–LL), and C7 sagittal vertical axis all within established age-adjusted thresholds with minimum 2-year follow-up. Health-related quality of life (HRQoL) scores: Oswestry Disability Index (ODI), 36-item Short Form health survey (SF-36), Scoliosis Research Society-22R (SRS22R), back/leg pain Numerical Rating Scale and minimum clinically important difference (MCID)/substantial clinical benefit (SCB). Two-year and preoperative HRQoL radiographic data were compared. Patients with mild scoliosis (Mild Scoli, Max coronal Cobb 10°–30°) were compared to those with larger curves (Scoli).Results: One hundred fifty-one patients included from 667 operative patients (82.8% women; average age, 56.4 ± 16.2 years). Forty-two patients (27.8%) included in Mild Scoli group. Mild Scoli group had significantly worse baseline leg pain, ODI, and physical composite scores (p < 0.02). Mean 2-year maximum coronal Cobb angle was significantly improved compared to baseline (p < 0.001). All 2-year HRQoL measures were significantly improved compared to (p < 0.001) except mental composite score, SRS activity and SRS mental for the Mild Scoli group (p > 0.05). From the mild Scoli group, 36%–74% met either MCID or SCB for the HRQoL measures. Sixty-four point three percent had minimum 1 complication, 28.6% had a major complication, 35.7% had reoperation.Conclusion: Mild scoliosis patients with age-appropriate sagittal alignment benefit from surgical correction, decompression, and stabilization at 2 years postoperative despite having a high complication rate.
Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention
Authors: Lee Byung-Jou , Bae Sung Soo , Choi Ho Young , Park Jin Hoon , Hyun Seung-Jae , Jo Dae Jean , Cho Yongjae ,   Korean Spinal Deformity Society (KSDS)
Published: September 2023

Proximal junction kyphosis (PJK) is a common imaging finding after long-level fusion, and proximal junctional failure (PJF) is an aggravated form of the progressive disease spectrum of PJK. This includes vertebral fracture of upper instrumented vertebra (UIV) or UIV+1, instability between UIV and UIV+1, neurological deterioration requiring surgery. Many studies have reported on PJK and PJF after long segment instrumentation for adult spinal deformity (ASD). In particular, for spine deformity surgeons, risk factors and prevention strategies of PJK and PJF are very important to minimize reoperation. Therefore, this review aims to help reduce the occurrence of PJK and PJF by updating the latest contents of PJK and PJF by 2023, focusing on the risk factors and prevention strategies of PJK and PJF. We conducted a search on multiple database for articles published until February 2023 using the search keywords “proximal junctional kyphosis,” “proximal junctional failure,” “proximal junctional disease,” and “adult spinal deformity.” Finally, 103 papers were included in this study. Numerous factors have been suggested as potential risks for the development of PJK and PJF, including a high body mass index, inadequate postoperative sagittal balance and overcorrection, advanced age, pelvic instrumentation, and osteoporosis. Recently, with the increasing elderly population, sarcopenia has been emphasized. The quality and quantity of muscle in the surgical site have been suggested as new risk factor. Therefore, spine surgeon should understand the pathophysiology of PJK and PJF, as well as individual risk factors, in order to develop appropriate prevention strategies for each patient.
Clinical Effectiveness of Artificial Disc Replacement in Comparison With Anterior Cervical Discectomy and Fusion in the Patients With Cervical Myelopathy: Systematic Review and Meta-analysis
Authors: Lee Jung Hwan , Lee Youn Joo , Chang Min Cheol , Lee Jun Ho
Published: September 2023

Objective: Cervical myelopathy (CM) describes the compressive cervical spinal cord state, often accompanied by serious clinical condition, by herniated disc or hypertrophied spurs or ligament. Anterior cervical discectomy and fusion (ACDF) has been frequently employed as conventional surgical solution for this CM despite its inherent biomechanical handicap. Alternatively, an artificial disc replacement (ADR) preserves cervical motion while still decompressing the spinal canal and neural foramen. This analysis elaborated to clarify the potential benefits of ADR application to CM over ACDF from the conglomerated results of the past references.Methods: A literature search was performed using MEDLINE, Embase, Cochrane review, and KMbase databases from the studies published until March 2023. Six studies (3 randomized controlled study [RCTs] and 3 non-RCTs) were included in a qualitative and quantitative synthesis. Data were extracted and analyzed using a random effects model to obtain effect size and its statistical significance. Quality assessment and evidence level were established in accordance with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology.Results: Among 6 studies, 2 studies showed that ADR group achieved significantly better clinical improvement than the ACDF group, while the rest 4 studies revealed no significant difference. A meta-analysis showed better clinical outcomes with or without statistical significance. The level of evidence was low because of inconsistency and imprecision.Conclusion: ADR was superior or at least, not inferior to ACDF in terms of functional recovery. However, its application to the CM patients is merely empowered with weak strength due to low level of evidence.
Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Procedure
Authors: Mun Junho , Hyun Seung-Jae , Lee Jae-Koo , An Sungjae , Kim Ki-Jeong
Published: September 2023

Objective: Multilevel or revisional posterior spinal surgery is prone to infection and delayed wound healing, related with the wound closure time and suture strength. Knotless barbed suture is an innovative self-locking, multianchor suture. This study aims to evaluate the safety and efficacy of the knotless barbed suture and self-adhering mesh with polymeric glue in multilevel or revisional posterior spinal surgery.Methods: This is a single-center retrospective matched cohort study. Patients were divided into 2 groups based on the wound closure method: barbed suture group with novel wound closure, and conventional suture group with conventional wound closure, 1:1 matched by the level of surgery and sex, resulting in 120 subjects each. Total operation time and wound closure time were measured intraoperatively, and perioperative clinical outcome parameters including postoperative wound complication were investigated for the first 3 months postoperatively. The distribution of continuous variables was assessed for normality by Shapiro-Wilk test, then parametric or nonparametric tests were applied accordingly (paired t-test or Wilcoxon signed-rank test).Results: Wound closure time was significantly shorter with the novel barbed suture than with conventional suture in all subgroups divided by the level of spinal surgery: 3–5, 6–9, ≥ 10 levels (p < 0.001). The 2 groups showed no significant differences in surgical complications (p = 1.000). Specially, total operation time and wound-closing time were significantly shorter in revisional subgroup.Conclusion: Absorbable knotless barbed suture and self-adhering mesh with polymeric glue can shorten spinal wound closure time with noninferiority in complications for multilevel or revisional spinal surgery.
Long-term Outcomes of Posterior Multilevel Crack Osteotomy: Revisional Surgery for Scoliosis With a Fusion Mass
Authors: Song Mi Hyun , Yang Jae Hyuk , Chang Dong-Gune , Nam Yunjin , Suh Seung Woo
Published: September 2023

Objective: Osteotomies are required for the mobilization of spinal segments in patients with revisional scoliosis surgery with a fusion mass; however, only a few techniques have shown efficacy and safety, and their mid- and long-term outcomes remain unelucidated. This study aimed to analyze long-term outcomes of the posterior multilevel crack osteotomy (PMCO) technique for revisional surgery for scoliosis with a fusion mass.Methods: Data from 18 patients who underwent revisional scoliosis surgery using PMCO between 2009 and 2015 and had more than 5-year follow-up were retrospectively reviewed. The Cobb angle and coronal and sagittal balance parameters were examined preoperatively, postoperatively, and during the final follow-up. Perioperative parameters and complications were also assessed.Results: Preoperative and postoperative Cobb angles were 60.5° and 29.9°, respectively (p < 0.001); this improvement was maintained until the final follow-up (33.4°, p = 0.058). The difference in preoperative and postoperative coronal balance was statistically significant (15.9 mm and 9.2 mm, respectively; p < 0.001); this was maintained until the final follow-up (p = 0.071). There was no change in sagittal balance parameters over the 3 measurement periods. Only 1 patient showed PMCO-related motor weakness, but he spontaneously recovered 3 months after postsurgery. Pseudarthrosis was not observed during the follow-up period.Conclusion: Incomplete osteotomy using PMCO provided satisfactory deformity correction without severe complications during revisional surgery for scoliosis with a fusion mass. It may be a less invasive procedure that maintains cortical continuity, preserves soft tissues, and provides sufficient mobility for the correction of spinal segments.
Comparative Efficacy of Clinical Interventions for Sacroiliac Joint Pain: Systematic Review and Network Meta-analysis With Preliminary Design of Treatment Algorithm
Authors: Liu Yanting , Suvithayasiri Siravich , Kim Jin-Sung
Published: September 2023

Objective: We aimed to identify the most effective clinical treatment method for sacroiliac joint (SIJ)-related pain based on the systematic review and network meta-analysis (NMA) to evaluate the comparative efficacy of clinical interventions for sacroiliac joint pain by pooling the randomized controlled trials (RCTs).Methods: Our team conducted a systematic review and NMA of RCTs to determine the most effective clinical treatment for SIJ-related pain. We searched the PubMed (MEDLINE), Web of Science, Cochrane Library, and Scopus databases for RCTs until February 2023. The PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines were followed. Pairwise and network meta-analyses were conducted using a random effects model.Results: Based on the search strategy and inclusion criteria, our systematic review and NMA included 9 randomized studies with 652 participants. Research has mainly focused on various radiofrequency sources, but their number is still low. In the network analysis, according to the NMA and mean ranking probabilities for the improvement of pain intensity (PI) and quality of life (QoL), sacroiliac joint fusion and cooled radiofrequency were associated with high treatment rank for improving PI and QoL in patients with sacroiliac joint pain.Conclusion: This NMA suggest that SIJ fusion and cooled radiofrequency could be potential options for improving the QoL and relieving pain in patients with SIJ-related pain. Comparison studies of outcomes between these 2 procedures with solid methodology and a low risk of bias would be very beneficial to identify the optimal treatment option for this challenging disease.
A Study on Factors Affecting Social Isolation among Young Adults: Foucing on Regional Comparison
Authors:   Crisis and Emergency Management: Theory and Praxis, Lee Soo-Bi , Jeon Yebin
Published: September 2023

This study multi-dimensionally examined the recently-aggravating social isolation of young adults in the capital area and non-capital area by focusing on its predictive factors. For this, the multiple regression analysis was conducted targeting total 521 young adults in their 19-39 by using the SPSS. In the results of this study, first, regardless of region, the age, relative deprivation, depression, and interpersonal relationship ability were the common factors that predicted isolation. Second, as the factors that could predict the isolation of young adults in the capital area, the matter of having a job, material deprivation, perception of housing had significant effects. Third, in regard of young adults in non-capital area, the controllability in case of economic crisis, and future prospect were significant. Based on such results, this study presented the integrated intervention measures for preventing the isolation of young adults, and especially discussed the policy direction and service measures by considering differences between capital area and non-capital area.
The Effects of Behavior Addiction on University Students’ Adaptation to School Life
Authors:   Crisis and Emergency Management: Theory and Praxis, Lee Hye Kyung
Published: September 2023

This study explored the effects of behavior addictions(smartphone addiction, gambling addiction, and relationship addiction) on university life adaptation. To this end, this paper collected data from 2nd to 4th-year students at K-University and used 227 data sets for the final analysis. As a result of the study, it was found that the level of smartphone addiction was above medium, relationship addiction was at a medium level, and gambling addiction was relatively low. Furthermore, it was observed that the more severe the smartphone addiction(β=-.131, p<.01), and the gambling addiction (β=-.125, p<.01), the lower the degree of adaptation to university life. Conversely, higher levels of self-efficacy were associated with a higher degree of adjustment to university life(β=.291, p<.001). Based on these results, it suggests that behavior addiction prevention programs, considering the characteristics of each type, should be developed and provided to prevent behavior addiction in university students. Additionally, there is a need for increased and proactive support and interest in adapting to university life.
Maternal-Child Health Related Experience of Childbearing Women Within 2years in Tigray, Ethiopia
Authors:   Crisis and Emergency Management: Theory and Praxis, Yu Juyoun , Park Jisun
Published: September 2023

This study was conducted using an explanatory sequential design mixed method to find out the awareness through maternal and child health (MCH)-related experiences of women who gave birth within 2 years among residents of Tigray, Ethiopia. Quantitative data and qualitative were obtained through survey (472 participants) and interviews (23 participants) respectively. As a result of the quantitative study, the performance of appropriate MCH care was not high, and Health extension workers were the most common MCH care giver. Although the compliance for required vaccinations and medications for child was higher, contraception for family planning was not high. Through the qualitative study, cultural differences towards pregnancy and childbirth and short of accessibility were revealed as the biggest obstacles. Despite these obstacles, efforts and awareness were made for healthy pregnancy, childbirth. Based on an understanding of cultural influence, it is necessary to promote the improvement of MCH standards through education and publicity.
Development of an Inspection Checklist for Landslide-Prone Areas
Authors:   Crisis and Emergency Management: Theory and Praxis, Lim Young Hyup , Lee Kwang Youn , Bae Hyun Seok , Lee Jin Ho , Park Jae Wan
Published: September 2023

Since 2012, a comprehensive investigation has been conducted to identify areas prone to landslides, with the objective of implementing preventive measures to mitigate the risk. To ensure effective monitoring, field inspections should be conducted at least twice a year in the designated landslide-prone areas. This study aimed to develop an inspection checklist for field assessments in landslide-prone areas by determining the key indicators and their respective weightings in terms of landslide risk. The effectiveness of the detailed inspection checklist was verified by applying it to landslide-prone areas. The analysis showed that the most useful way to categorize landslides was into three main types: soil slopes, rock slopes, and debris flows. The inspection items showed a high weightage towards dynamic vulnerability. The application of inspection checklists to landslide-prone areas suggests that implementing class-based criteria (Classes A, B, C) is a rational approach for the management of these landslide-prone areas.
Estimation of Carbon Dioxide Emission from a Fires with Burn Severity: Focusing on the Case of 2021 Andong Wildfire
Authors:   Crisis and Emergency Management: Theory and Praxis, Lee Ye Eun , Han Song Hee , Woo Choong Sik , Kwon Chun Geun , Kim Sung Yong
Published: September 2023

In this study, carbon dioxide emission from the 2021 Andong forest fire was analyzed with burn severity, which was classified into high(crown fire), moderate(heat damage), and low(surface fire). Drone videos of the wildland fire area were taken using a multispectral sensor based on UAV and classified by grouping the differences in derived NDVI values between satellite images before the fire and UAV images immediately after the fire. Fuel load consumption and carbon dioxide emission from forest fires were estimated through field investigation of each burn severity site. According to the results of this study, the total burned areas were calculated to be 350ha, of which H(crown fire), M(heat damage), and L(surface fire) were to be 85ha, 125ha, and 141ha, respectively. 15.40ton/ha fire carbon dioxide in H(crown fire), 4.92ton/ha in M(heat damage), 4.69ton/ha in L(surface fire) were emitted from the fire. The total amount of carbon dioxide emitted by the Andong forest fire in 2021 was estimated to be 2,570 tons.
Factors Affecting People's Adherence to Precautionary Rules in a Public Health Emergency Based on Health Belief Model: Focusing on the Moderating Effect of Optimistic Bias
Authors:   Crisis and Emergency Management: Theory and Praxis, Seo Yeong-Mi , Choi Won-Hee
Published: September 2023

This study was conducted to determine the effects of the health belief and optimistic bias on COVID-19 preventive behaviors. Data were collected from 311 adults using a questionnaire. The collected data were analyzed through descriptive statistics and structural equation modeling, and multigroup analysis was performed to analyze the moderating effect. The results showed that all HBM variables, except for perceived susceptibility, had statistically significant effects on COVID-19 preventive behaviors. Perceived susceptibility, perceived severity, perceived benefits, and cues to action had statistically significant effects on the optimistic bias group, and perceived benefits, perceived barriers, and cues to action affected the group without optimistic bias. A statistically significant moderating effect was found only for perceived severity. The results of this study are expected to contribute to the establishment of crisis response policies by contributing to the establishment effective and elaborate strategies that promote individual preventive behaviors to cope with COVID-19 pandemic.
A Study on Approaches to Addressing Crises Experienced by Out-of-School Youth
Authors:   Crisis and Emergency Management: Theory and Praxis, Kim Na Yeong , Kim Kwang Byung
Published: September 2023

This study focuses on the crises experienced by out-of-school youth, with attention to the recent increase in the number of out-of-school youth. Through a review of various previous studies, it was revealed that out-of-school youth not only experience psychological and emotional crises, but also addiction, delinquency, violence, and crises in the workplace. In order to address the crises experienced by out-of-school youth, the roles of the national and local government, educational authorities and schools, centers that support out-of-school youth, professionals, and local communities are presented. Based on this, it emphasizes the need for various collaborative support to overcome the crises that out-of-school youth may experience. Previous studies have not addressed the comprehensive crises experienced by out-of-school youth, and this study has significance and uniqueness in presenting various roles to address those crises.
Disaster Management Resource Operation System: Analyzing the Perception Difference between Disaster Management Administrative Officials and Fire-fighters
Authors:   Crisis and Emergency Management: Theory and Praxis, An Longtian , Lee Jae Eun
Published: September 2023

This study aims to analyze the perception differences between disaster management administrative officials and fire-fighters in disaster management resource operation system. To achieve the research purpose, we surveyed the perception of disaster management resources operation between local government disaster management administrative officials and fire-fighters, and difference analysis was conducted through the SPSS program. As a result of this study, we found that the two groups had similar perceptions in terms of the possibility of disaster damage and the needs for disaster management resources. And there are differences on cooperation factors and the effectiveness of the disaster management resource operation system between two groups, and local government disaster management administrative officials have a relatively positive perception than fire-fighters. Therefore, it is necessary to consider the perception and opinion of various participating departments in disaster management resource operation system, including local government disaster management administrative officials and fire-fighters when making plans in the future.
Understanding the role of plasmalogen lipid in synapse function: a cellular neurolipidomics study
Authors: Sadilova Anna , Nubi Laila , Howard David , Filipponi Carolina , Lai Michele , Sassi Martina , Angelini Roberto
Published: September 2023

This research aims to reveal fundamental mechanisms of neurodegenerative disorders by studying the consequences of disrupted lipid homeostasis in neurons by means of functional synapse assays and protein expression analyses. In neurodegeneration, the physiology of synapses is altered. Here, plasmalogen lipids are abundant and their peculiar conical shape makes them ideal in supporting vesicle fusion. In addition, plasmalogen levels decrease with pathological progression in Alzheimer’s disease. Since current evidence is correlative, we aim to provide tools to directly test whether plasmalogens support synaptic transmission for normal neuronal cell function. Specifically, we seek to prove that plasmalogens are required for synapse function and later explore their potential for neuro-regenerative supplementation therapies.

My work will include western blot and ICC/IF detection of markers of mature neurons (NeuN,b3- tubulin) alongside established synaptic and vesicular markers (Synaptophysin1, PSD95, SV2, VAChT), and an assay for neurotransmitter release (Ach). Wet-lab assays will be performed on otherwise untreated differentiated cells alongside differentiated cells genetically silenced by using siRNA for plasmalogen biosynthetic enzymes FAR1 and PEDS1. Specifically, we will modulate plasmalogen levels in differentiated human SH-SY5Y cells as they embody a convenient model for developing assays. This work will be complemented with lipidomic analyses and will be soon translated to relevant iPSC-derived neurons.

Based on our preliminary data and previous literature, we expect the data from lipidomic and synaptic assays to be normally distributed. Comparison of multiple groups (n=6) at one timepoint (e.g., normal vs plasmalogen-deficient) will use one-way ANOVA with Bonferroni correction (GraphPad Software).
Using Poisson proximity-based weights for traffic flow state prediction
Authors: Uglickich Evženie , Nagy Ivan
Published: September 2023

The development of traffic state prediction algorithms embedded in intelligent transportation systems is of great importance for improving traffic conditions for drivers and pedestrians. Despite the large number of prediction methods, existing limitations still confirm the need to find a systematic solution and its adaptation to specific traffic data. This paper focuses on the relationship between traffic flow states in different urban locations, where these states are identified as clusters of traffic counts. Extending the recursive Bayesian mixture estimation theory to the Poisson mixtures, the paper uses the mixture pointers to construct the traffic state prediction model. Using the predictive model, the cluster at the target urban location is predicted based on the traffic counts measured in real time at the explanatory urban location. The main contributions of this study are: (i) recursive identification and prediction of the traffic state at each time instant, (ii) straightforward Poisson mixture initialization, and (iii) systematic theoretical background of the prediction approach. Results of testing the prediction algorithm on real traffic counts are presented.
Into the Jungle!
Authors: Kugler Jimmy , Kugler Michael
Published: September 2023

The history of American youth depends primarily on adult reminiscences of their own childhoods, of adults testifying about other youth, or surmises based on a few artifacts. For comic art, we typically rely on the youthful work of prominent artists from the urban East Coast. Following World War II, a small-town Nebraska youth, James “Jimmy” Kugler (1932-1968), drew more than a hundred, six-panel comic strip stories, retelling the Pacific War fought by humanoid “Frogs” and “Toads” committed to a kill-or-be-killed conflict. The survival of such a large collection of adolescent comic strips from America’s small-town Midwest is remarkable. This book reproduces these artefacts from an adolescent imagination, as a microhistory of American youth in that formative era. It offers not only the likely comic book models for these stories, but also inspiration from coverage of the war in newspapers, radio, movies, and newsreels. American propaganda intended to inspire wartime patriotism gave this young artist a license for his imagined violence, in some ways racially charged. In a context of progressive American educational reform, these violent comic stories, often set in places like the artist’s small Nebraska town, expressed adolescent rebellion, confirming comic art’s reputation for “outsider” defiance to moral conventions. These comics reflect the transition in American taste from war stories to the horror comics of the late 1940s and early 1950s. The thick description of this adolescent art explains how a small-town boy from the plains distilled the popular culture of his day for an imagined war he could fight on his audacious terms.
“You Swore To Tell The Truth”
Authors: Anderson Devery S.
Published: September 2023

This chapter discusses the trial of Clyde Kennard in a segregated courtroom inside the Forrest County Courthouse. It details how Attorney Jess Brown represented his client and was skeptical of the jury. Brown addressed the court, declaring that the prosecution had failed to prove its case against Kennard, and motioned for the judge to declare Kennard as not guilty. However, the state's case against Kennard had its problems. Judge Stanton Hall overruled the motion and instructed bailiffs to bring back the jury, and the trial would continue as such. The chapter also looks into the contradiction between testimonies and witnesses.
“How Can You Continue To Fight?”
Authors: Anderson Devery S.
Published: September 2023

This chapter notes the aftermath of the Evers trial, which involved Johnny Lee Roberts and Clyde Kennard. Despite his health and his mother's needs, Judge Stanton Hall refused bail so Kennard stayed at the county jail to await the decision to either release him or hasten his departure to the state penitentiary. Moreover, Kennard was denied his right to due process under the Fourteenth Amendment to the US Constitution. State Penitentiary at Parchman was a notoriously brutal institution. Any racial hatred or distrust that existed within individual minds and bodies before they were locked up inevitably made its way inside the prison.
“Dreams That Live After Death”
Authors: Anderson Devery S.
Published: September 2023

This chapter focuses on the legacy that Clyde Kennard left. Tougaloo College hosted a concert celebrating the American Festival of Negro Arts and featured acclaimed pianist Robert S. Pritchard, who played his composition about Clyde Kennard. Even though Mississippi moved on from Kennard's death, Pritchard could not shake the injustice Kennard faced. The tragedy of Kennard's story could never be fully understood until his Sovereignty Commission file was opened to the public, revealing internal memos proving Kennard had been targeted and wronged. The chapter then looks into the African American Student Organization's establishment and its annual Clyde Kennard celebration.
“Until Justice Is Restored”
Authors: Anderson Devery S.
Published: September 2023

This chapter tackles the work on Clyde Kennard's behalf in Chicago as a joint effort between the Center on Wrongful Convictions and Stevenson High School's National History Day Club. According to Center on Wrongful Conviction's Steve Drizin, the University of Southern Mississippi vested interest in making sure that the University owned up to its role in this miscarriage of justice. Kennard's legal troubles began with his first arrest in 1959 and never were resolved until 2007. The chapter explores how much of Johnny Lee Roberts' story changed over the years since the trial testimony. It also notes that Roberts' passed away a day before the dedication of the Clyde Kennard Memorial Highway.
Visions of Invasion
Authors: Lechuga Michael
Published: September 2023

Visions of Invasion is a study of how the United States (US) government mobilizes media and surveillance technologies to operate a highly networked, multidimensional system for controlling migrants. Building on Rhetorical Studies, Settler Colonial Studies, and Media Studies theories, this book offers a glimpse at how the processes of “alien making” contribute to an ongoing settler colonial project in the U.S. Visions of Invasion illustrates that popular culture texts like alien invasion films manufacture alienhood—a settler colonial political subjectivity embedded in the U.S. colonial consciousness—via emergent visual media technologies. The alien-making process, though, is not limited to Hollywood. It is a nation-wide practice that produces migrants as subjective “terrorists,” felons, and other non-citizen personae that are commonly vilified in public discourse. Thus, this book describes how the settler colonial logics that motivated early US colonizers materialize in both its citizenship control policy and in some of the country’s most popular alien invasion narratives over the last four decades. The case studies in this book uncover an anxious colonial logic that drives settlers’ obsession to manufacture narratives of false invasion from abroad that pose an existential threat to the settler way of life. Visions of Invasion is a deep dive into how the rhetorical figure of the alien has been manufactured through media and surveillance technologies in the U.S. as a political subjectivity, one that plays out the anxieties, guilts, and fears of settler colonialism in today’s science fiction landscape.
The Struggle of Struggles
Authors: Pigee Vera
Published: September 2023

From 1955 to 1975, Vera Mae Pigee (1924-2007) put her life and livelihood on the line with grassroots efforts for social change in Mississippi, principally through her years of leadership in Coahoma County’s NAACP during the civil rights movement. Known as the “Lady of Hats” by the NAACP executive secretary, Roy Wilkins, she was a businesswoman, mother, and leader, and her book offers a detailed view of the daily grind of organizing for years, to open the state’s closed society. Fearless, forthright, and fashionable, Mrs. Pigee also suffered for her efforts in the hands of white supremacists and those unwilling to accept strong women leading – the struggle of struggles. She wrote herself into the histories, confronted the misinformation, and self-published one of the first autobiographies from the struggle. Women like her worked, often without accolade or recognition, in their communities all over the country, but did not document their efforts in this way. The Struggle of Struggles spotlights the gendered and generational tensions within the movement. It outlines the complexity, frustrations, snubs, as well as the joy and triumphs that she experienced and witnessed in the quest for a fairer and more equitable nation. This republication begins with a detailed introductory essay by Françoise Hamlin, who interviewed Mrs. Pigee and her daughter in the few years preceding their passing, as well as co-workers, and current activists. This autobiography contains annotations for clarity and explanation, in addition to a timeline to guide a new generation of readers.
African American Adolescent Female Heroes
Authors: Marotta Melanie A.
Published: September 2023

This monograph acknowledges the history and legacy of enslavement in America at a time when it is crucial that we do so. With the second wave of Black Lives Matter, inequalities in publishing have been brought to light, resulting in an influx of Young Adult speculative fiction publications featuring African American young women. Dealing with the twenty-first century contributions along, fiction writers and academic theorists have either been excluding African American young women from speculative fiction or refuse to place these young women in the role of hero. Further, theoretical examinations appear to be concentrating on the absence of African American people from speculative fiction and stereotypical representation. The fact is that African American adolescent young women do exist in twenty-first century speculative fiction, however, in many cases they tend to be a recreation of the enslaved women from American antebellum slave narratives. Further, once #BlackGirlMagic texts come to fruition, there is a revelation of positive African American adolescent young women heroes. The application of the neo-slave narrative structure to the twenty-first-century Young Adult text is investigated in this monograph. For this study, texts from the twenty-first century have been selected, thereby ensuring that the examination is new, relevant, and necessary.
Le mur et ses ornements, Tome I - Texte
Authors: Titeux Catherine
Published: September 2023

Le sujet de la thèse de Catherine Titeux est le mur en tant qu’élément du « décor », tel que l’Âge classique l’entend. Pour les architectes et les théoriciens du XVIe et du XVIIe siècle, le mur contribue à la beauté de l’édifice. Différentes techniques de finition permettent de l’embellir : appareils en pierre de taille dressés et ravalés, bossages, briques polychromes, enduits qui unifient et enluminent les parements. Qu’il soit nu ou orné le mur n’est jamais neutre. Etudiant un vaste corpus, l'auteur confirme certaines observations sur la façade française : l’effet a-tectonique des ornements, même si ceux-ci structurent la composition. Au principe classique de l’unité de l’organisme architectural, dans lequel rien ne peut être ajouté ou retranché, les architectes français apportent leur réponse : tous les éléments sont des ornements ainsi que le mur lui-même, qui se montre ou se voile de légers ornements.

Catherine Titeux est architecte (ENSA de Paris Belleville), Docteur en Histoire de l'art et archéologie (Paris 4 Sorbonne). Elle enseigne à l’École Nationale Supérieure d’Architecture de Montpellier dans les champs Histoire et Cultures Architecturales et Théories et Pratiques du Projet Architectural et Urbain. Ses recherches portent sur le langage de l'architecture, sur l'ornement, sur les figures de la muralité qu'elle a particulièrement étudiées chez Leon Battista Alberti et dans l'architecture classique française.
Des raisons du lieu
Authors: Pleitinx Renaud
Published: September 2023

Prenant appui sur la Théorie de la Médiation, cet article propose une explication de l’architecture avec le souci préalable de remplir les conditions épistémologiques d’une telle explication.
Tetralogía de Fallot: Revisión sistemática para un abordaje integral
Authors: Ayala Viloria Alfonso , Penagos Ruiz Johana , González-Torres Henry J , Holguín Betancourt Claudia , Ayala Viloria Álvaro
Published: September 2023

La tetralogía de Fallot es una cardiopatía congénita cianosante compleja, con prevalencia considerable a nivel mundial, la cual requiere intervención en el primer año de vida, cuyas características clínicas tendrán variación conforme al grado de obstrucción pulmonar y la edad de presentación. Objetivo: Presentar una revisión sistemática de cómo debe realizarse el abordaje integral de la tetralogía de Fallot de acuerdo con la literatura actual. Metodología: Se realizó una revisión sistemática utilizando términos del MeSH y DeCS como “Tetralogía de Fallot”, “defectos del tabique interventricular”, “hipertrofia ventricular derecha”, “hipertensión pulmonar”, “defectos cardíacos congénitos”, “enfermedades y anomalías congénitas, hereditarias y neonatales”. La fuente fueron Sciencedirect, PubMed, Scopus y WoS. Se escogieron artículos indexados originales y metaanálisis. Conclusión: El pronóstico y las secuelas a largo plazo dependerá del diagnóstico oportuno, manejo médico y quirúrgico óptimos y, por tanto, del conocimiento fisiopatológico de la misma.
Hipotermia: conceptos claves
Authors: Martínez Sánchez Lina María , Duque Echeverri Laura , Gil Ramos Jose Manuel , Cuartas Agudelo Yuban Sebastián
Published: September 2023

La hipotermia se define como una temperatura corporal < 36 °C. Muchos factores predisponentes se han descrito, tales como el uso de anestésicos, fármacos de premedicación, baja temperatura del entorno, e intervenciones quirúrgicas abdominales son factores que pueden contribuir a su desarrollo. La hipotermia accidental se ha descrito como predictor de peores resultados clínicos, además de mayor mortalidad, mayores requerimientos de transfusión de productos sanguíneos y un tiempo de estancia hospitalaria prolongado. Para el manejo de esta entidad se pueden utilizar sistemas de calefacción y ventilación para asegurar una temperatura estable y humedad adecuada que proporcionen comodidad térmica al paciente; este abordaje cuenta con una gran tasa de efectividad. Por lo tanto el objetivo del presente artículo es describir las estrategias para el manejo de los pacientes con hipotermia accidental en el servicio de urgencias. Se realizó una revisión de literatura en inglés y en español en las bases de datos de PubMed y Elsevier desde Agosto del año 2021 hasta Enero del 2022, mediante la utilización de palabras claves y términos del DeCS como hipotermia y urgencias médicas. Según la información encontrada el diagnóstico de la hipotermia accidental se debe realizar de manera rápida para posteriormente realizar una clasificación adecuada que permitan un enfoque apropiado del paciente tanto en el entorno prehospitalario como hospitalario, así mismo este debe ser individualizado y guiado por metas de reanimación.
Evaluación de los niveles de actividad física en estudiantes universitarios mediante método indirecto
Authors: Moreno Bolívar Hilario , Castillo Mejía José Alejandro , Valencia Echeverry Jhon Edward
Published: September 2023

El presente estudio tuvo como Objetivo caracterizar el nivel de actividad física en estudiantes del instituto educativo técnico profesional del municipio de Roldanillo Valle. Materiales y métodos: estudio con enfoque cuantitativo y alcance descriptivo contó con una muestra representativa no probabilística de 304 sujetos, de los cuales 162 (53,2%) eran mujeres y 142 (46,7%) hombres; el instrumento empleado fue el cuestionario GPAQ Global Physical Activity Questionnaire, valorando con ello los METS en las categorías: desplazamiento, trabajo, tiempo libre y conducta sedentaria. Resultados: sobre los niveles AF a nivel general, el 62,5 % de los estudiantes evaluados presentaron un nivel alto, un 12,2% moderado y un 25,3% bajo. En la distribución por género, los hombres presentaron un mayor nivel de AF con relación a las mujeres (p<0,05). Pero estas últimas a su vez tuvieron un mayor tiempo de AF sedentaria que los hombres (p<0,05). Conclusiones: se encontró una relación asociada entre el género y los niveles de AF, siendo ésta superior en el caso de los hombres; por su parte, los planes de estudio a nivel universitario deben fomentar e incluir la AF dentro de la formación integral, realizando mayor énfasis en las estudiantes del género femenino.
Trombocitopenia inmune primaria refractaria y el uso de terapia combinada, reporte de caso
Authors: Imbachí Salamanca Alex Jhonier , Orozco Burbano Juan David , Correa Correa Mario Ernesto
Published: September 2023

La trombocitopenia inmune primaria es un trastorno autoinmune adquirido, caracterizado por una destrucción plaquetaria excesiva, derivada de la producción de anticuerpos contra la membrana plaquetaria, conllevando a un alto riesgo de hemorragia para el paciente. Actualmente, la piedra angular del tratamiento sigue siendo el uso de agentes de primera línea como los glucocorticoides y la inmunoglobulina intravenosa. Sin embargo, en algunos casos los pacientes pueden ser refractarios a estos, con el requerimiento de terapias de segunda y tercera línea. Se presenta el caso clínico de una paciente de 25 años con historia de trombocitopenia inmune primaria con presentación severa por la presencia de sangrado gastrointestinal y estado anémico asociado, con refractariedad a diferentes estrategias de tratamiento, incluida la esplenectomía, requiriendo posterior manejo combinado con Rituximab, con el cual se logró mantener un recuento plaquetario adecuado. Consideramos que este caso toma interés clínico dado los escasos reportes de casos de esta condición y la limitada evidencia que se tiene ante las terapias secuenciales en pacientes refractarios a tratamiento de primera línea.