bluuebunny/crossref_metadata_2025 huggingface dataset:
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Authors: Nelson Josefine , Sjöblom Helen , Gjertsson Inger , Ulven Stine M. , Lindqvist Helen M. , Bärebring Linnea
Published: September 2020

The aim was to compile the evidence from Randomized Controlled Trials (RCTs) of diet or dietary supplements used to reduce disease activity in adults with Rheumatoid Arthritis (RA). Searches were performed in the databases PubMed, Scopus and Cochrane. Only RCT studies of diets, foods or dietary supplements, looking at effects on the Disease Activity Score in 28 joints (DAS28) among adults with RA, published in peer-reviewed journals, were included. A total of 27 articles were included—three of whole diets (Mediterranean diet, raw food and anti-inflammatory diet), five of food items, five of n-3 fatty acids, five of single micronutrient supplements, four of single antioxidant supplements and five of pre-, pro- or synbiotics. Studies that showed moderate strength evidence for positive effects on disease activity in RA included interventions with a Mediterranean diet, spices (ginger powder, cinnamon powder, saffron), antioxidants (quercetin and ubiquinone), and probiotics containing Lactobacillus Casei. Other diets or supplements had either no effects or low to very low strength of evidence. In conclusion, RCT studies on diet or dietary supplements are limited in patients with RA, but based on the results in this review there is evidence that some interventions might have positive effects on DAS28.
Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Moringa oleifera Leaves and Seed Residue (MOLSr) Extracts
Authors: Lim Wai Feng , Mohamad Yusof Mohd Izwan , Teh Lay Kek , Salleh Mohd Zaki
Published: September 2020

Moringa oleifera is a miracle plant with many nutritional and medicinal properties. Chemopreventive values of the combined mixture of moringa leaves and seed residue (MOLSr) at different ratios (M1S9, M1S1 and M9S1) were investigated. MOLSr extracts were subjected to phytochemical screening, antioxidant assays, metabolite profiling and cytotoxic activity on the primary mammary epithelial cells (PMECs), non-malignant Chang’s liver cells and various human cancer cell lines (including breast, cervical, colon and liver cancer cell lines). The MOLSr ratio with the most potent cytotoxic activity was used in xenograft mice injected with MDA-MB-231 cells for in vivo tumorigenicity study as well as further protein and gene expression studies. M1S9, specifically composed of saponin and amino acid, retained the lowest antioxidant activity but the highest glucosinolate content as compared to other ratios. Cell viability decreased significantly in MCF-7 breast cancer cells and PMECs after treatment with M1S9. Solid tumor from MDA-MB-231 xenograft mice was inhibited by up to 64.5% at third week after treatment with high-dose M1S9. High-dose M1S9 significantly decreased the expression of calcineurin (CaN) and vascular endothelial cell growth factor (VEGF) proteins as well as the secreted frizzled-related protein 1 (SFRP1) and solute carrier family 39 member 6 (SLC39A6) genes. This study provides new scientific evidence for the chemoprevention potential of MOLSr extracts in a breast cancer model; however, the precise mechanism warrants further investigation.
Macrophage Polarization and Osteoporosis: A Review
Authors: Muñoz Joseph , Akhavan Neda S. , Mullins Amy P. , Arjmandi Bahram H.
Published: September 2020

Over 200 million people suffer from osteoporosis worldwide. Individuals with osteoporosis have increased rates of bone resorption while simultaneously having impaired osteogenesis. Most current treatments for osteoporosis focus on anti-resorptive methods to prevent further bone loss. However, it is important to identify safe and cost-efficient treatments that not only inhibit bone resorption, but also stimulate anabolic mechanisms to upregulate osteogenesis. Recent data suggest that macrophage polarization may contribute to osteoblast differentiation and increased osteogenesis as well as bone mineralization. Macrophages exist in two major polarization states, classically activated macrophages (M1) and alternatively activated macrophage (M2) macrophages. The polarization state of macrophages is dependent on molecules in the microenvironment including several cytokines and chemokines. Mechanistically, M2 macrophages secrete osteogenic factors that stimulate the differentiation and activation of pre-osteoblastic cells, such as mesenchymal stem cells (MSC’s), and subsequently increase bone mineralization. In this review, we cover the mechanisms by which M2 macrophages contribute to osteogenesis and postulate the hypothesis that regulating macrophage polarization states may be a potential treatment for the treatment of osteoporosis.
A Low FODMAP Diet Is Nutritionally Adequate and Therapeutically Efficacious in Community Dwelling Older Adults with Chronic Diarrhoea
Authors: O’Brien Leigh , Skidmore Paula , Wall Catherine , Wilkinson Tim , Muir Jane , Frampton Chris , Gearry Richard
Published: September 2020

The low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP)diet has been extensively researched, but not in the management of older adults with functional gastrointestinal symptoms. This study determines the positive and negative impacts of this dietary treatment in older adults with chronic diarrhea. A non-blinded intervention study was conducted with adults over 65 years with chronic diarrhea referred for colonoscopy where no cause was found. Participants followed a dietitian-led low FODMAP diet for six weeks and completed a structured assessment of gastrointestinal symptoms, the Hospital Anxiety and Depression scale, and a four-day food diary before and after the intervention. Twenty participants, mean age 76 years, were recruited. Adherence to the low FODMAP diet was acceptable; mean daily FODMAP intake reduced from 20.82 g to 3.75 g (p < 0.001) during the intervention and no clinically significant changes in macro- or micronutrient intakes were observed. There were clinically significant improvements in total gastrointestinal symptoms (pre diet 21.15/88 (standard deviation SD = 10.99), post diet 9.8/88 (SD = 9.58), p < 0.001) including diarrhea (pre diet 9.85 (SD = 3.84), post diet 4.05 (SD = 3.86), p < 0.001) and significant reductions in anxiety (pre diet 6.11/21 (SD = 4.31), post diet 4.26/21 (SD = 3.38), p < 0.05). In older adults the low FODMAP diet is clinically effective and does not jeopardise nutritional intake when supervised by an experienced dietitian.
Weight Reduction by the Low-Insulin-Method—A Randomized Controlled Trial
Authors: Röhling Martin , Martin Katharina , Ellinger Sabine , Schreiber Michael , Martin Stephan , Kempf Kerstin
Published: September 2020

Continuous high insulin levels are associated with weight gain and lead to cardiometabolic diseases. Therefore, we have developed the Low-Insulin-Method and integrated it into the multi-component, occupational healthcare program SHAPE-AND-MOTION-Medical-Accompanied-Slimming (SAMMAS) to reduce daily insulin levels for long-term weight reduction in overweight or obesity. Employees were randomized into a starting intervention group (SI, n = 15) or waiting list control group (WL, n = 15). SAMMAS consisted of group-based seminars, low-carbohydrate nutrition including formula diet, continuous glucose monitoring, telemetric monitoring, and telemedical coaching. Both groups received telemetric devices at baseline. Intention-to-treat analyses were performed after 12, 26, and 52 weeks. The estimated treatment difference in weight reduction after 12 weeks, which is the primary endpoint of the study, showed a pronounced effect in favour of SI (−6.3 kg with (95% confidence interval) (−7.4; −4.5) (p < 0.001)) after 12 weeks. Furthermore, SI improved fasting blood glucose, HbA1c, quality of life, fasting insulin, blood pressure, and eating behaviour (all p < 0.05) in the within-group analysis, while WL did not. After 26 and 52 weeks, weight reduction could be maintained in the whole group (both groups together) by −6.7 kg (−9.5; −3.8) (p < 0.001) and −6.1 kg (−9.2; −2.7) (p < 0.01). SAMMAS supports clinically relevant weight reduction and long-term weight loss maintenance in individuals with overweight or obesity.
Energy and Nutrient Intake of Americans according to Meeting Current Dairy Recommendations
Authors: Hess Julie M. , Cifelli Christopher J. , Fulgoni III Victor L.
Published: September 2020

Most Americans do not meet dairy food recommendations from the 2015 Dietary Guidelines for Americans (DGA). This study assesses differences in nutrient intake between Americans who meet recommendations for dairy intake and those who do not, using data from the National Health and Nutrition Examination Survey from 2013–2014 and 2015–2016 (n = 5670 children ages 2–18 years and n = 10,112 adults ages 19+). Among children and adults, those meeting dairy food recommendations were significantly more likely to have adequate intake (% above Estimated Average Requirement (EAR)) of calcium, magnesium, phosphorus, riboflavin, vitamin A, vitamin B12, and zinc and consume above the Adequate Intake (AI) for potassium and choline than Americans not meeting dairy recommendations, regardless of age, sex, or race/ethnicity. Americans meeting dairy recommendations were also more likely to exceed recommendations for sodium and saturated fat but consume less added sugars. Nearly 60% of Americans 2 years and older not meeting dairy recommendations consumed calcium and magnesium below the EAR. Only about 20% of Americans who did not meet dairy recommendations consumed above the AI for potassium. Dairy foods make important and unique contributions to dietary patterns, and it can be difficult to meet nutrient needs without consuming recommended amounts of dairy foods.
Cyclic Oligosaccharides as Active Drugs, an Updated Review
Authors: Matencio Adrián , Caldera Fabrizio , Cecone Claudio , López-Nicolás José Manuel , Trotta Francesco
Published: September 2020

There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-based materials used for drug delivery, but the capacity of CDs to complex different agents and their own intrinsic properties suggest they might also be considered for use as active drugs, not only as carriers. The aim of this review is to summarize the direct use of CDs as drugs, without using its complexing potential with other substances. The direct application of another oligosaccharide called cyclic nigerosyl-1,6-nigerose (CNN) is also described. The review is divided into lipid-related diseases, aggregation diseases, antiviral and antiparasitic activities, anti-anesthetic agent, function in diet, removal of organic toxins, CDs and collagen, cell differentiation, and finally, their use in contact lenses in which no drug other than CDs are involved. In the case of CNN, its application as a dietary supplement and immunological modulator is explained. Finally, a critical structure–activity explanation is provided.
A Second Generation Mn-Porphyrin Dimer with a Twisted Linker as a Potential Blood Pool Agent for MRI: Tuning the Geometry and Binding with HSA
Authors: Liu Hanlin , Cheng Weiran , Dong Shili , Xu David Feng , Tang Keith , Zhang Xiao-an
Published: September 2020

Blood-pool agents (BPAs) are MRI contrast agents (CAs) characterized by their long circulation in the vascular system to provide an extended time window for high-resolution MR angiography (MRA). Prolonged vascular retention, however, impedes the excretion of BPAs. Therefore, chemical strategy to regulate the balance between retention and clearance is important to reach optimal pharmacokinetics. We recently developed MnP2, the first Mn(III)-porphyrin (MnP) based BPA. MnP2 shows high T1 relaxivity (r1) and high affinity to human serum albumin (HSA) that leads to up to 48-h vascular retention in rats. However, upon albumin binding, the r1 is decreased. To modulate vascular retention time and plasma r1, a regioisomer of MnP2, m-MnP2, was synthesized. The free m-MnP2 exhibits lower r1 than that of MnP2 at magnetic fields above 2 MHz, which agrees with their relative hydrodynamic sizes. The HSA binding of m-MnP2 was evaluated using UV-Vis spectroscopy and found to have tuned-down affinity in comparison with MnP2. Upon HSA binding, the protein complex of m-MnP2 exhibits an r1 of 11.8 mM−1 s−1 at 3 T, which is higher than that of MnP2 bound to HSA. Taken together, this demonstrated the role of molecular geometry in optimizing the pharmacokinetics of albumin-targeting BPAs.
Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes
Authors: Riccardi Claudia , Capasso Domenica , Coppola Angela , Platella Chiara , Montesarchio Daniela , Di Gaetano Sonia , Roviello Giovanni N. , Musumeci Domenica
Published: September 2020

We here report our studies on the reaction with the platinum(II) ion of a nucleoamino acid constituted by the l-2,3-diaminopropanoic acid linked to the thymine nucleobase through a methylenecarbonyl linker. The obtained new platinum complexes, characterized by spectroscopic and mass spectrometric techniques, were envisaged to exploit synergistic effects due to the presence of both the platinum center and the nucleoamino acid moiety. The latter can be potentially useful to protect the complexes from early deactivation, as well as to facilitate their cell internalization. The biological activity of the complexes in terms of antiproliferative effects was evaluated in vitro on different cancer cell lines and healthy cells, showing the best results on human cervical adenocarcinoma (HeLa) cells along with good selectivity for cancer over normal cells. In contrast, the metal-free nucleoamino acid did not show any cytotoxicity on both normal and cancer cell lines. Finally, the ability of the novel Pt(II) complexes to bind various DNA model systems was investigated by circular dichroism (CD) spectroscopy and polyacrylamide gel electrophoresis analyses proving that the newly obtained compounds can potentially target DNA, similarly to other well-known anticancer Pt complexes, with a peculiar G-quadruplex vs. duplex selectivity.
Statistical Design of Sustained-Release Tablet Garcinia cambogia Extract and Bioconverted Mulberry Leaf Extract for Anti-Obesity
Authors: Lee Hye-Jin , Na Young-Guk , Han Mingu , Pham Thi Mai Anh , Lee Hyeonmin , Lee Hong-Ki , Myung Chang-Seon , Han Joo-Hui , Kang Jong-Seong , Kim Kyung-Tae , Cho Cheong-Weon
Published: September 2020

Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality. Herbal supplements and diet-based therapies have attracted interest in the treatment of obesity. It is known that Garcinia cambogia (GA) and mulberry leaf, which contain polyphenols, have anti-obesity activity. Herein, we developed a combined tablet consisting of GA extract and bioconverted mulberry leaf extract (BMUL) using a statistical design approach. The ratio and amount of sustained polymers were set as factors. In the cell study, the combination of GA and BMUL showed synergistic anti-obesity activity. In a statistical model, the optimized amounts of hydroxypropyl methylcellulose 2208 (HPMC 2208) and polyethylene oxide 303 (POLYOX 303) were 41.02% and 58.98%, respectively. Additionally, the selected ratio of microcrystalline cellulose (MCC) was 0.33. When the release, hardness, and friability of the GABMUL tablet were evaluated, the error percentages of the response were lower than 10%. This indicates that the GABMUL tablet was successfully prepared.
Development of Liposomal Vesicles for Osimertinib Delivery to EGFR Mutation—Positive Lung Cancer Cells
Authors: Skupin-Mrugalska Paulina , Minko Tamara
Published: September 2020

Osimertinib (OSI, AZD9291), is a third-generation, irreversible tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) that selectively inhibits both EGFR-TKI–sensitizing and EGFR T790M resistance mutations. OSI has been approved as a first-line treatment of EGFR-mutant lung cancer and for metastatic EGFR T790M-mutant non-small cell lung cancer. Liposome-based delivery of OSI can provide a new formulation of the drug that can be administered via alternative delivery routes (intravenous, inhalation). In this manuscript, we report for the first time development and characterization of liposomal OSI formulations with diameters of ca. 115 nm. Vesicles were composed of phosphatidylcholines with various saturation and carbon chain lengths, cholesterol and pegylated phosphoethanolamine. Liposomes were loaded with OSI passively, resulting in a drug being dissolved in the phospholipid matrix or actively via remote-loading leading to the formation of OSI precipitate in the liposomal core. Remotely loaded liposomes were characterized by nearly 100% entrapment efficacy and represent a depot of OSI. Passively-loaded vesicles released OSI following the Peppas-Sahlin model, in a mechanism combining drug diffusion and liposome relaxation. OSI-loaded liposomes composed of l-α-phosphatidylcholine (egg-PC) demonstrated a higher toxicity in non-small lung cancer cells with EGFR T790M resistance mutation (H-1975) when compared with free OSI. Developed OSI formulations did not show antiproliferative activity in vitro in healthy lung epithelial cells (MRC-5) without the EGFR mutation.
Russeting in Apple Is Initiated After Exposure to Moisture Ends—I. Histological Evidence
Authors: Chen Yun-Hao , Straube Jannis , Khanal Bishnu P. , Knoche Moritz , Debener Thomas
Published: September 2020

Russeting (periderm formation) is a critical fruit-surface disorder in apple (Malus × domestica Borkh.). The first symptom of insipient russeting is cuticular microcracking. Humid and rainy weather increases russeting. The aim was to determine the ontogeny of moisture-induced russeting in ‘Pinova’ apple. We recorded the effects of duration of exposure to water and the stage of fruit development at exposure on microcracking, periderm formation and cuticle deposition. Early on (21 or 31 days after full bloom; DAFB) short periods (2 to 12 d) of moisture exposure induced cuticular microcracking—but not later on (66 or 93 DAFB). A periderm was not formed during moisture exposure but 4 d after exposure ended. A periderm was formed in the hypodermis beneath a microcrack. Russeting frequency and severity were low for up to 4 d of moisture exposure but increased after 6 d. Cuticle thickness was not affected by moisture for up to 8 d but decreased for longer exposures. Cuticular ridge thickness decreased around a microcrack. In general, moisture did not affect cuticular strain release. We conclude that a hypodermal periderm forms after termination of moisture exposure and after microcrack formation. Reduced cuticle deposition may cause moisture-induced microcracking and, thus, russeting.
A Collagen-Based Scaffold for Promoting Neural Plasticity in a Rat Model of Spinal Cord Injury
Authors: Yeh Jue-Zong , Wang Ding-Han , Cherng Juin-Hong , Wang Yi-Wen , Fan Gang-Yi , Liou Nien-Hsien , Liu Jiang-Chuan , Chou Chung-Hsing
Published: September 2020

In spinal cord injury (SCI) therapy, glial scarring formed by activated astrocytes is a primary problem that needs to be solved to enhance axonal regeneration. In this study, we developed and used a collagen scaffold for glial scar replacement to create an appropriate environment in an SCI rat model and determined whether neural plasticity can be manipulated using this approach. We used four experimental groups, as follows: SCI-collagen scaffold, SCI control, normal spinal cord-collagen scaffold, and normal control. The collagen scaffold showed excellent in vitro and in vivo biocompatibility. Immunofluorescence staining revealed increased expression of neurofilament and fibronectin and reduced expression of glial fibrillary acidic protein and anti-chondroitin sulfate in the collagen scaffold-treated SCI rats at 1 and 4 weeks post-implantation compared with that in untreated SCI control. This indicates that the collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning. Our study highlights the feasibility of using the collagen scaffold in SCI repair. The collagen scaffold was found to exert beneficial effects on neuronal activity and may help in manipulating synaptic plasticity, implying its great potential for clinical application in SCI.
Investigation of the Adsorption Behavior of Jet-Cooked Cationic Starches on Pulp Fibers
Authors: Ferstl Esther , Gabriel Martin , Gomernik Florian , Müller Stefanie Monika , Selinger Julian , Thaler Ferula , Bauer Wolfgang , Uhlig Frank , Spirk Stefan , Chemelli Angela
Published: September 2020

The optimization of the thermal treatment of cationic starch in the paper industry offers the opportunity to reduce the energy consumption of this process. Four different industrially relevant cationic starches, varying in source, cationization method and degree of substitution were treated by a steam-jet cooking procedure, comparable to industrially employed starch cooking processes. The influence of the starch properties and cooking parameters on the adsorption behavior of the starches on cellulosic pulp was investigated. The adsorbed amount was affected by the cooking temperature and the type of starch. For some starch grades, a cooking temperature of 115 °C can be employed to achieve sufficient starch retention on the pulp fibers. The energy consumption could further be reduced by cooking at higher starch concentrations without loss of adsorption efficiency.
Tribological Performance of Nylon Composites with Nanoadditives for Self-Lubrication Purposes
Authors: Clavería Isabel , Gimeno Sofía , Miguel Ignacio , Mendoza Gemma , Lostalé Aleida , Fernández Ángel , Castell Pere , Elduque Daniel
Published: September 2020

A systematic study comparing the wear behaviour of composites with nylon matrix (PA66, PA46, PA12) and different nanoadditives and reinforcing additives (graphite, graphene, MoS2 and ZrO2) has been carried out in order to achieve a proper self-lubricant material for bearing cages. The wear characterisation was done using pin-on-disc tests, SEM and EDX analysis. The results show that better outcomes are obtained for composites based on PA12. The addition of ZrO2 offers negative values of wear due to the metallic particle transference from the counterface to the polymeric pin.
Influence of Accelerated Weathering on the Mechanical, Fracture Morphology, Thermal Stability, Contact Angle, and Water Absorption Properties of Natural Fiber Fabric-Based Epoxy Hybrid Composites
Authors: Yorseng Krittirash , Mavinkere Rangappa Sanjay , Parameswaranpillai Jyotishkumar , Siengchin Suchart
Published: September 2020

Epoxy-based biocomposites are a good alternative for metals in lightweight applications. This research has been focused on the effect of accelerated weathering on the mechanical, thermal, contact angle, and water absorption behavior of neat epoxy, individual kenaf and sisal, and kenaf/sisal hybrid epoxy composites. The composite was fabricated by hand layup method. Among the various composites studied, sisal/kenaf/sisal hybrid epoxy composites showed the best properties and retained the thermo-mechanical properties with the lowest water absorption properties even after the weathering test. Thus, composites with hybridized kenaf and sisal with sisal outer layer are encouraging semistructural materials in outdoor applications.
A Global Archive of Coseismic DInSAR Products Obtained Through Unsupervised Sentinel-1 Data Processing
Authors: Monterroso Fernando , Bonano Manuela , Luca Claudio De , Lanari Riccardo , Manunta Michele , Manzo Mariarosaria , Onorato Giovanni , Zinno Ivana , Casu Francesco
Published: September 2020

We present an automatic and unsupervised tool for the systematic generation of Sentinel-1 (S1) differential synthetic aperture radar interferometry (DInSAR) coseismic products. In particular, the tool first retrieves the location, depth, and magnitude of every seismic event from interoperable online earthquake catalogs (e.g., the United States Geological Survey (USGS) and the Italian National Institute of Geophysics and Volcanology (INGV) and then, for significant (with respect to a set of selected thresholds) earthquakes, it automatically triggers the downloading of S1 data and their interferometric processing over the area affected by the earthquake. The automatic system we developed has also been implemented within a Cloud-Computing (CC) environment, specifically the Amazon Web Services, with the aim of creating a global database of DInSAR S1 coseismic products, which consist of displacement maps and the associated wrapped interferograms and spatial coherences. This information will progressively be made freely available through the European Plate Observing System (EPOS) Research Infrastructure, thus providing the scientific community with a large catalog of DInSAR data that can be helpful for investigating the dynamics of surface deformation in the seismic zones around the Earth. The developed tool can also support national and local authorities during seismic crises by quickly providing information on the surface deformation induced by earthquakes.
Validation of Water Vapor Vertical Distributions Retrieved from MAX-DOAS over Beijing, China
Authors: Lin Hua , Liu Cheng , Xing Chengzhi , Hu Qihou , Hong Qianqian , Liu Haoran , Li Qihua , Tan Wei , Ji Xiangguang , Wang Zhuang , Liu Jianguo
Published: September 2020

Water vapor vertical profiles are important in numerical weather prediction, moisture transport, and vertical flux calculation. This study presents the Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) retrieval algorithm for water vapor vertical profiles and the retrieved results are validated with corresponding independent datasets under clear sky. The retrieved Vertical Column Densities (VCDs) and surface concentrations are validated with the Aerosol Robotic Network (AERONET) and National Climatic Data Centre (NCDC) datasets, achieving good correlation coefficients (R) of 0.922 and 0.876, respectively. The retrieved vertical profiles agree well with weekly balloon-borne radiosonde measurements. Furthermore, the retrieved water vapor concentrations at different altitudes (100–2000 m) are validated with the corresponding European Centre for Medium-range Weather Forecasts (ECMWF) ERA-interim datasets, achieving a correlation coefficient (R) varying from 0.695 to 0.857. The total error budgets for the surface concentrations and VCDs are 31% and 38%, respectively. Finally, the retrieval performance of the MAX-DOAS algorithm under different aerosol loads is evaluated. High aerosol loads obstruct the retrieval of surface concentrations and VCDs, with surface concentrations more liable to severe interference from such aerosol loads. To summarize, the feasibility of detecting water vapor profiles using MAX-DOAS under clear sky is confirmed in this work.
On the Assessment of Non-Local Multi-Looking in Detection of Persistent Scatterers Using SAR Tomography
Authors: Aghababaei Hossein
Published: September 2020

Synthetic aperture radar (SAR) tomography has shown great potential in multi-dimensional monitoring of urban infrastructures and detection of their possible slow deformations. Along this line, undeniable improvements in SAR tomography (TomoSAR) detection framework of multiple permanent scatterers (PSs) have been observed by the use of a multi-looking operation that is the necessity for data’s covariance matrix estimation. This paper attempts to further analyze the impact of a robust multi-looking operation in TomoSAR PS detection framework and assess the challenging issues that exist in the estimation of the covariance matrix of large stack data obtained from long interferometric time series acquisition. The analyses evaluate the performance of non-local covariance matrix estimation approaches in PS detection framework using the super-resolution multi-looked Generalized Likelihood Ratio Test (GLRT). Experimental results of multi-looking impact assessment are provided using two datasets acquired by COSMO-SkyMED (CSK) and TerraSAR-X (TSX) over Tehran, Iran, and Toulouse, France, respectively. The results highlight that non-local estimation of the sample covariance matrix allows revealing the presence of the scatterers, that may not be detectable using the conventional local-based framework.
Introducing an Improved GRACE Global Point-Mass Solution—A Case Study in Antarctica
Authors: Ferreira Vagner G. , Yong Bin , Seitz Kurt , Heck Bernhard , Grombein Thomas
Published: September 2020

In the so-called point-mass modeling, surface densities are represented by point masses, providing only an approximated solution of the surface integral for the gravitational potential. Here, we propose a refinement for the point-mass modeling based on Taylor series expansion in which the zeroth-order approximation is equivalent to the point-mass solution. Simulations show that adding higher-order terms neglected in the point-mass modeling reduces the error of inverted mass changes of up to 90% on global and Antarctica scales. The method provides an alternative to the processing of the Level-2 data from the Gravity Recovery and Climate Experiment (GRACE) mission. While the evaluation of the surface densities based on improved point-mass modeling using ITSG-Grace2018 Level-2 data as observations reveals noise level of approximately 5.77 mm, this figure is 5.02, 6.05, and 5.81 mm for Center for Space Research (CSR), Goddard Space Flight Center (GSFC), and Jet Propulsion Laboratory (JPL) mascon solutions, respectively. Statistical tests demonstrate that the four solutions are not significant different (95% confidence) over Antarctica Ice Sheet (AIS), despite the slight differences seen in the noises. Therefore, the estimated noise level for the four solutions indicates the quality of GRACE mass changes over AIS. Overall, AIS shows a mass loss of −7.58 mm/year during 2003–2015 based on the improved point-mass solution, which agrees with the values derived from mascon solutions.
A Comprehensive Study on Light Signals of Opportunity for Subdecimetre Unmodulated Visible Light Positioning
Authors: Bastiaens Sander , Deprez Kenneth , Martens Luc , Joseph Wout , Plets David
Published: September 2020

Currently, visible light positioning (VLP) enabling an illumination infrastructure requires a costly retrofit. Intensity modulation systems not only necessitate changes to the internal LED driving module, but decrease the LEDs’ radiant flux as well. This hinders the infrastructure’s ability to meet the maintained illuminance standards. Ideally, the LEDs could be left unmodulated, i.e., unmodulated VLP (uVLP). uVLP systems, inherently low-cost, exploit the characteristics of the light signals of opportunity (LSOOP) to infer a position. In this paper, it is shown that proper signal processing allows using the LED’s characteristic frequency (CF) as a discriminative feature in photodiode (PD)-based received signal strength (RSS) uVLP. This manuscript investigates and compares the aptitude of (future) RSS-based uVLP and VLP systems in terms of their feasibility, cost and accuracy. It demonstrates that CF-based uVLP exhibits an acceptable loss of accuracy compared to (regular) VLP. For point source-like LEDs, uVLP only worsens the trilateration-based median p50 and 90th percentile root-mean-square error p90 from 5.3cm to 7.9cm (+50%) and from 9.6cm to 15.6cm (+62%), in the 4m × 4m room under consideration. A large experimental validation shows that employing a robust model-based fingerprinting localisation procedure, instead of trilateration, further boosts uVLP’s p50 and p90 accuracy to 5.0cm and 10.6cm. When collating with VLP’s p50=3.5cm and p90=6.8cm, uVLP exhibits a comparable positioning performance at a significantly lower cost and at a higher maintained illuminance, all of which underline uVLP’s high adoption potential. With this work, a significant step is taken towards the development of an accurate and low-cost tracking system.
MS Location Estimation Based on the Artificial Bee Colony Algorithm
Authors: Chen Chien-Sheng , Huang Jen-Fa , Huang Nan-Chun , Chen Kai-Sheng
Published: September 2020

With the mature technology of wireless communications, the function of estimating the mobile station (MS) position has become essential. Suppressing the bias resulting from non-line-of-sight (NLSO) scenarios is the main issue for a wireless location network. The artificial bee colony (ABC) algorithm, based on the depiction of bee swarm’s foraging characteristics, is widely applied to solve optimization problems in several fields. Based on three measurements of time-of-arrival (TOA), an objective function is used to quantify the additional NLOS error on the MS positioning scheme. The ABC algorithm is adopted to locate the most precise MS location by minimizing the objective function value. The performance of the proposed positioning methods is verified under various error distributions through computer simulations. Meanwhile, the localization accuracy achieved by other existing methods is also investigated. According to the simulation results, accurate estimation of the MS position is derived and therefore the efficiency of the localization process is increased.
New Insights towards High-Temperature Ethanol-Sensing Mechanism of ZnO-Based Chemiresistors
Authors: Piliai Lesia , Tomeček David , Hruška Martin , Khalakhan Ivan , Nováková Jaroslava , Fitl Přemysl , Yatskiv Roman , Grym Jan , Vorokhta Mykhailo , Matolínová Iva , Vrňata Martin
Published: September 2020

In this work, we investigate ethanol (EtOH)-sensing mechanisms of a ZnO nanorod (NRs)-based chemiresistor using a near-ambient-pressure X-ray photoelectron spectroscopy (NAP-XPS). First, the ZnO NRs-based sensor was constructed, showing good performance on interaction with 100 ppm of EtOH in the ambient air at 327 °C. Then, the same ZnO NRs film was investigated by NAP-XPS in the presence of 1 mbar oxygen, simulating the ambient air atmosphere and O2/EtOH mixture at the same temperature. The partial pressure of EtOH was 0.1 mbar, which corresponded to the partial pressure of 100 ppm of analytes in the ambient air. To better understand the EtOH-sensing mechanism, the NAP-XPS spectra were also studied on exposure to O2/EtOH/H2O and O2/MeCHO (MeCHO = acetaldehyde) mixtures. Our results revealed that the reaction of EtOH with chemisorbed oxygen on the surface of ZnO NRs follows the acetaldehyde pathway. It was also demonstrated that, during the sensing process, the surface becomes contaminated by different products of MeCHO decomposition, which decreases dc-sensor performance. However, the ac performance does not seem to be affected by this phenomenon.
Spatial Equity with Census Population Data vs. Floating Population Data: The Distribution of Earthquake Evacuation Shelters in Daegu, South Korea
Authors: Lee Yoon Ha , Lee Ji Soo , Baek Seung Chan , Hong Won Hwa
Published: September 2020

The spatial equity of outdoor evacuation sites designated for emergency evacuation must be secured. In particular, public administrators must ensure spatial equity in preparing for unpredictable evacuation demands, such as earthquakes. This study analyzed the spatial equity of earthquake evacuation shelters in Daegu, South Korea, by using population data at the local level by time- and date-based mobile phone location data (i.e., floating population data). We compared our analysis of the spatial equity and error rate in this case with census data. Ultimately, our results demonstrate that the use of census population data can cause significant error in evaluations of the equity of evacuation shelter accessibility when the floating population data acquired through mobile phone location data are assumed exact.
Science-Driven Societal Transformation, Part II: Motivation and Strategy
Authors: Boik John C.
Published: September 2020

Climate change, biodiversity loss, and other well-known social and environmental problems pose grave risks. Progress has been insufficient, and as a result, scientists, global policy experts, and the general public increasingly conclude that bold change is required. At least two kinds of bold change are conceivable: reform of existing societal systems (e.g., financial, economic, and governance systems), including their institutions, policies, and priorities; and transformation, understood here as the de novo development of and migration to new and improved systems. The latter has barely been explored in the scientific literature and is the focus of this concept paper. The main theses explored are that transformation is prudent, given risks, attractive, given potential benefits, and achievable, given political, social, and financial constraints. A body of literature is cited in support, but that body is necessarily small given the novelty of the topic. In particular, there are almost no papers in the scientific literature addressing the “how to?” of transformation, a central theme of this paper. Thus, this paper serves in part to raise topics and bring attention to possibilities and new directions.
Global Challenges as Opportunity to Transform Business for Good
Authors: Laszlo Chris , Cooperrider David , Fry Ron
Published: September 2020

Using insights from Peter Drucker’s Theory of the Business framework, the authors show that global challenges such as pandemics and climate change are contributing to a critical misalignment between businesses and their increasingly complex external environments, leading to a growing malaise in many organizations. Central to this misalignment are seven legacy assumptions which no longer serve businesses effectively. Seven new assumptions better reflect today’s external environment and point to how businesses can thrive (“Do Well”) by making a positive difference in society (“Do Good.”) The authors propose a set of change management methods and tools along with specific steps that leaders and organizations can take to transform their businesses into what they define as Positive Institutions.
Developing a Wine Experience Scale: A New Strategy to Measure Holistic Behaviour of Wine Tourists
Authors: Santos Vasco , Ramos Paulo , Almeida Nuno , Santos-Pavón Enrique
Published: September 2020

This study develops a scale to measure wine tourism experiences and was tested in Portugal, in two of the main wine tourism centres: Porto and Madeira. The wine experience scale combines experience traits with the traditional approach to scales related to wine tourism. The development of the scale follows the most recognised validated procedures. Data were collected from a total of 647 international wine tourists in the wine cellars of the two main fortified wine tourism regions visiting areas: Porto and Madeira. Structural equation modelling (SEM-AMOS) was used as the main analysis and validation tool. The resulting 18-item wine experience scale comprises four major dimensions: (1) Wine storytelling, (2) wine tasting excitement, (3) wine involvement, and (4) winescape. All these showed reliable and validated indicators. This new scale presents a valid new tool to better measure and evaluate experiences in a wine tourism setting. This study offers a broad range of use for academics, managers, planners, and practitioners. It shows how a new measurement tool focused on the wine tourism experience in terms of several outcomes and applications, addressing important practical managerial implications, can have an impact on academic research. Most previous tourism scales still fail to measure the specifics of wine settings. This is the first scale that comprises the dimensions of experience with wine senses, applied in a relevant wine destination where research is still limited. The results are relevant in boosting the increasingly recognized awareness of Portugal as wine tourism, as well as bringing experience scales to the body of knowledge.
Efficiency of Polder Modernization for Flood Protection. Case Study of Golina Polder (Poland)
Authors: Laks Ireneusz , Walczak Zbigniew
Published: September 2020

This paper presents an analysis of the effectiveness of variants of the reconstruction of a polder, which is part of the flood protection system of a large urban agglomeration. The Golina polder, located in the floodplain of the Warta River, was selected as the case study. The multi-criteria decision support methods AHP and Fuzzy AHP were used to assess the effectiveness of individual variants. Information on the floods from 1997 and 2010, data on land cover, land development, nature and historical objects were used to estimate the value of the coefficients for the multi-criteria decision methods. It was shown that the planned deep modernization of the hydrotechnical infrastructure and the purchase of land in the polder area is less effective than maintaining the current state of development of the polder.
Impacts of River Engineering on Multi-Decadal Water Discharge of the Mega-Changjiang River
Authors: Ma Binbin , Pang Wenhong , Lou Yaying , Mei Xuefei , Wang Jie , Gu Jinghua , Dai Zhijun
Published: September 2020

Knowledge of river engineering impacts on water discharge is significant to flow guidelines and sustainable water resource managements for balancing human consumption and the natural environment. In this study, based on the collected multi-decadal discharge data at Yichang, Hankou, and Datong stations, we determined that in October, Three Gorges Dam contributed 34.4%, 24.5%, and 18.7% to the discharge decrease in the upper, middle, and lower reach, respectively, while Gezhouba Dam contributed 14.5%, 10.7%, and 10%. Danjiangkou Reservoir caused the discharge ratio of Hanjiang to Changjiang to decline from 7.2% during 1954–1973 to 6.3% during 1973–2014. Owing to growing water withdrawal and consumption, we suggest that the distribution of water diversion and consumption should be regulated to prevent the probable occurrence of the severe issue of salt water intrusion in the Changjiang Estuary in 2028.
Socioeconomic Factors and Sustainable Forage Crops Production in Turkey Aegean Region: A Multivariate Modeling
Authors: Cevher Celal , Altunkaynak Bulent
Published: September 2020

The aim of this study is to evaluate the effect of farmers’ socioeconomic characteristics on sustainable forage crop production after forage crop subsidies. One of the innovative aspects of the study is the simultaneous modeling of alfalfa, silage corn and vetch production efficiency. For this, the multivariate linear regression model was used. In this way, the effect of socioeconomic characteristics on production is more clearly demonstrated by taking into account the dependency structure between forage crop production. For the study, 487 farmers in the Aegean region, where fodder crops can be produced throughout the year, were interviewed face-to-face and data were collected through a questionnaire. According to the results obtained, it was determined that the width of the land had a positive effect on the increase in alfalfa, silage corn, and vetch production. The number of animals was found to have a positive effect on alfalfa and silage maize production growth. The production of alfalfa was higher in rural farmers, and vetch production was higher in urban farmers. Farmers who do not have non-agricultural income focused on vetch production, and farmers with non-agricultural income focused on alfalfa production. It was seen that the majority of the farmers participating in the study were primary school graduates and lived in rural areas. In general, a significant increase was observed in the production of silage corn, vetch, and alfalfa, respectively. After the subsidies, it was concluded that this increase in the production of silage corn, vetch, and alfalfa was not at a level to meet the amount of forage crops needed by animal husbandry.
A Novel Multi-Objective Model for the Cold Chain Logistics Considering Multiple Effects
Authors: Qiu Feiyue , Zhang Guodao , Chen Ping-Kuo , Wang Cheng , Pan Yi , Sheng Xin , Kong Dewei
Published: September 2020

This paper focuses on solving a problem of green location-routing with cold chain logistics (GLRPCCL). Considering the sustainable effects of the economy, environment, society, and cargos, we try to establish a multi-objective model to minimize the total cost, the full set of greenhouse gas (GHG) emissions, the average waiting time, and the total quality degradation. Several practical demands were considered: heterogeneous fleet (HF), time windows (TW), simultaneous pickup and delivery (SPD), and a feature of mixed transportation. To search the optimal Pareto front of such a nondeterministic polynomial hard problem, we proposed an optimization framework that combines three multi-objective evolutionary algorithms (MOEAs) and also developed two search mechanisms for a large composite neighborhood described by 16 operators. Extensive analysis was conducted to empirically assess the impacts of several problem parameters (i.e., distribution strategy, fleet composition, and depots’ time windows and costs) on Pareto solutions in terms of the performance indicators. Based on the experimental results, this provides several managerial insights for the sustainale logistics companies.
From Seafarers to E-farers: Maritime Cadets’ Perceptions Towards Seafaring Jobs in the Industry 4.0
Authors: Jo Sohyun , D’agostini Enrico , Kang Jun
Published: September 2020

Efforts to implement the concept of autonomous transport in the shipping industry are currently underway with the introduction of Maritime Autonomous Surface Ship (MASS), which is expected to usher in a new paradigm in maritime trade. However, this requires a stable supply of highly qualified seafarers. Predicting the changes necessary for seafarer education and training in the MASS era is pivotal for the safe and efficient development and operation of autonomous ships. The present study conducted a survey using Q methodology on fourth year students of the Korea Maritime and Ocean University (KMOU), to examine their perceptions towards changes in ship organizations, and the competency of seafarers required in the MASS era. From the analysis, we extracted three unique clusters of cadets’ perceptions towards new competencies with the introduction of MASS: “the traditional seafarers’ centric role retainer”, the “ship organizational structure domain achiever”, and the “new technical competences builder”. The emerging findings can predict the educational needs and new competences of seafarers in the MASS era, as well as support managerial implications. These results are expected to serve in establishing the future direction of seafarer education and training in both private and public organisations.
Role of Viral Ribonucleoproteins in Human Papillomavirus Type 16 Gene Expression
Authors: Kajitani Naoko , Schwartz Stefan
Published: September 2020

Human papillomaviruses (HPVs) depend on the cellular RNA-processing machineries including alternative RNA splicing and polyadenylation to coordinate HPV gene expression. HPV RNA processing is controlled by cis-regulatory RNA elements and trans-regulatory factors since the HPV splice sites are suboptimal. The definition of HPV exons and introns may differ between individual HPV mRNA species and is complicated by the fact that many HPV protein-coding sequences overlap. The formation of HPV ribonucleoproteins consisting of HPV pre-mRNAs and multiple cellular RNA-binding proteins may result in the different outcomes of HPV gene expression, which contributes to the HPV life cycle progression and HPV-associated cancer development. In this review, we summarize the regulation of HPV16 gene expression at the level of RNA processing with focus on the interactions between HPV16 pre-mRNAs and cellular RNA-binding factors.