bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental aspects of the development of tourism
Authors:   Zakarpattya regional center for socio-economic and humanitarian research NAS of Ukraine, Mikhaylyuk Inna
Published: January 2023

At the present stage, considerable attention is paid to the problems of harming the environment, which arises as a result of uncontrolled or unreasonably burdensome tourism and recreational activities for natural landscapes. The article highlights certain ecological aspects of the development of the tourism and recreation sphere. It is determined what impact the growth of mass tourism has on the natural and recreational potential and the natural environment.As you know, the policy of intensifying the use of tourist-recreation potential leads to an increase in the load on the ecosystem. Therefore, first of all, it is necessary to form a policy and develop a strategy for the development of tourism not separately, but as an integral part of a unified regional policy based on the principles of sustainable ecologic economic development.An important factor in the development of tourism is maintaining a balance between ecological, economic and social components. First of all, environmental factors of development should be taken into account: optimal anthropogenic load on the natural resources of the territory, diversification of types of tourism: the formation of ecolo-gically oriented directions, which will make it possible to achieve a balanced develop-ment of tourism.The policy of the development of the tourist and recreational sphere, taking into account the environmental impact, is becoming more and more urgent and relevant. The protection and transformation of recreational areas includes the determination of load standards for natural complexes, the allocation of green zones and resort forests, the protection of recreational lands, forest management measures, the protection of underground water and mineral resources and sources, and the preservation of the purity of the air basin.The rapid development of tourist and recreational activities is reflected in the massive, sharp increase in the number of tourists, includingmotorists. Issues of protection of natural resources should be resolved long before the start of exploitation of the recreational area, i.e. at the design stage.Keywords:ecological aspects, tourist and recreational activities, impact and consequences, balance.
Open access: a journey from impossible to probable, but still uncertain
Authors: Anglada Lluís , Abadal Ernest
Published: January 2023

An overview of the evolution of open access (OA) to scientific publications over the last 20 years is presented. This retrospective look allows us to make two observations that seem to overlap: on the one hand, how close the initial objective seems to be to what initially seemed utopian and, on the other, the unanticipated and solid obstacles that open access has encountered along the way, as well as the unexpected and diverse solutions that are emerging to overcome them. The overall assessment of OA is positive, and it underscores that open access is (or is becoming) possible, that it is good, and that it is necessary. However, this overall positive evolution has come up against two major obstacles that are slowing its progress: the double payments generated by hybrid journals (subscription and article processing charges [APCs]) and the unchecked growth in APCs. In addition, this intensive use of APCs is creating a publishing gap between publishers that charge fees to authors and those that do not, and ultimately, it is causing dissension regarding the (previously shared) strategy toward open access. There are no immediate, one-off solutions to overcome the aforementioned dysfunctions, although three actions that, in the medium term, can remedy them can be mentioned: changing the approach to the evaluation of science, adopting measures to regulate APCs, and promoting alternative publication models. Finally, it should be noted that OA has acted as the vanguard and spearhead of a broader movement: that of open science.
Terminology system as linguistic component of language for special purposes: principles of analysis and systematization
Authors: Balmagambetova Zh.T. , Karimbek A.E.
Published: January 2023

In this article the required base for linguistic study of the formation of the conceptual and terminological apparatus of the tourism sphere was clarified. The development of the terminology system of the tourism sector materialize in the conditions of continuous accumulation and systematic organization of quantitative and qualitative changes related both to the process of lexical updating of the body of terms, as well as to the processes of clarifying concepts and transforming existing definitions of terms under the influence of external socio-cultural and historical-political factors. In the light of the systemic approach, the formation of the conceptual and terminological apparatus of the tourism sector is considered as a complex multidimensional process. Its development is determined by the action of a combination of intra-scientific and inter-scientific factors, reflects the general linguistic laws of development and the specifics of enrichment of the terminology of the tourism sector in the manifestation of signs relevant for all types of systems: hierarchical and structural, integrity and unity, connection with the social and historical-cultural environment of the functioning of the language in the society of its users. Terminological changes characterize the conceptual-terminological apparatus primarily from the side of quantitative savings, in other words, they reflect the process of increasing thecomposition of terms, which is regarded as an enrichment of the conceptual-terminological apparatus of science. The ongoing study of new tourism terms should show the enriching (or possibly different) nature of these changes.
Precedent Phenomena as a Way of Transmitting the Author's Intention
Authors: Nikiforova E.Sh. , Simanchuk Ye.A.
Published: January 2023

The article discusses a wide range of precedent phenomena in the texts on politics and economics within English media discourse. The author emphasizes the fact that precedent texts, being one of the ways of reflecting the peculiarities of a linguistic culture, are exploited by compilers of media texts in order to activate and explicate additional meanings and connotations. The overwhelming majority of the reviewed texts is characterized by the use of the category of precedence as a way to express the author's intention through referential and evaluative functions, when, through a precedent phenomenon, the journalist encodes his assessment in relation to the events described. In addition, precedent texts often perform a password function that saves linguistic resources and, thus, the author's intention is expressed in a more concise form, making a reference to the mental-verbal base of the audience.
Достижение адекватности перевода вымышленного языка «надсат» на русский язык
Authors: Мозжегорова Е.Н. , Засецкова Е.Н.
Published: January 2023

Статья посвящена изучению проблемы достижения адекватности перевода художественной литературы, а именно  исследованию особенностей функционирования вымышленного языка в романе Энтони Бёрджесса «Заводной апельсин» и специфики его перевода на русский язык. Авторский вымышленный язык в художественном произведении представляет собой интерес как особый культурный код, являющийся важнейшим составляющим самого произведения, написанного в эпоху модернизма, а также как продукт одного из видов языковой деятельности. Адекватный перевод художественногопроизведения и его особенностей позволяет в полной мере раскрыть авторский замысел. Целью исследования является сравнение двух вариантов перевода романа-антиутопии «Clockwork Orange» на русский язык. Особое внимание уделено выявлению имеющихся в арсенале теории и практики перевода способов достижения адекватности перевода элементов вымышленного языка «надсат» в контексте художественного произведения. На современном этапе достижение адекватности перевода художественных произведений остается по-прежнему актуальной проблемой переводоведения и лингвистики. Основная цель адекватного перевода достигается, если мысли автора переданы в соответствующей оригиналу форме, без нарушений стилистических, грамматических и лексических норм языка.
«Мен де оны тырнағынан таныдым...» (Абайдың астарлы сөздері)
Authors: Жұртбай Т.
Published: January 2023

Мақалада бүгінгі таңда абайтану іліміне қатысты ең өзекті мəселелер көтерілген. Абайдың өлеңдері текстологиялық-мəтіндік тұрғыдан талданып, ғылыми пайымдаулар жасалған. Абайдың азаматтық көзқарасына қатысты осы уақытқа дейін теріс түсіндіріліп, не бұрмаланып келген оқиғалардың астарын ашатын өмірлік деректерге негізделіп ұсынылған. Абайдың жеке өміріне қатысты зерттеулер мен естеліктердегі мағлұматтар архив мұраларымен салыстырылып, бір ізге түсіріліп, авторлықкөзқарас тұрғысынан сараланған. Сонымен қатар, абайтану іліміне қатысты кейінгі жарты ғасырда айтылып жүрген əр түрлі сыңаржақ пікірлерге тойтарыс берілген. «Өлең — сөздің патшасы, сөз сарасы» мен «Біреудің кісі өлсе — қаралы ол» жəне «Бай сейілді, бір бейілді» мен «Бойы былғаң, сөзі жылмаң», Сегіз аяқ» өлеңдеріне мəтіндік талдау жасалған. Мазмұндық қолданысына қатысты сыңаржақ пікірлер айтылған сөз, сөз тіркесі, өлең тармақтарына түсініктеме жазылған. Мысалы, қиуа,ақ шом, табытын қаққан, баспақ, саспақ т.б. сөздердің қолданылу аясы, контекстегі мағынасы сараланған. Ақынның жарық көрген шығармалар жинағында берілген мəтіндік түсініктемелер де назардан тыс қалмаған. Мəтіндік талдаудың ғылыми бірізділігі жайлы да өз тұжырымдары ұсынылған.
Bem-estar animal no contexto da cadeia produtiva de alimentos
Authors: Oliveira Vinícius José de , Navasquez Lucas Maurício Lopes , Gomes Wytter Rodrigues Velasco , Pereira Douglas Alves
Published: January 2023

A implementação de práticas de produção animal pautadas no bem-estar tem assumido um papel importante no mercado de produtos de origem animal, pois proporcionam alimentos de qualidade e tratam os animais de maneira digna. Diante disso, esse short paper objetivou discutir os aspectos relacionados a elaboração e instalação dos princípios de bem-estar animal e seu impacto na qualidade dos produtos e comércio ético e competitivo.
Charismatic Leadership Kh. Zezen Zinal Abidin Bazul Asyhab In Education of Iqomah Nusantara
Authors: Koswara Nandang , Rostini Deti , Zein Aang Abdullah , Zein Iis Farida , Anggaraeni Dian
Published: January 2023

Research on charismatic leadership KH. Zezen Zainal Abidin Bazul Asyhab in building the Qoryah Mubarokah Association (IQOMAH) association is a research related to the ability of leaders to influence others towards a better and life. Based on the data obtained, the focus of the Iqomah program is the enforcement of Islamic law in the field of Worship, named as the practice of the Islamic Pillars correctly and earnestly. The research includes the type of field research (field research) with qualitative methods. Based on this method, facts were found in the field, using observational data collection techniques, interviews and documentation of Iqomah's programs and policies. The first conclusion is that charismatic leadership is the ability of leaders to influence members in particular and society in general to achieve the vision and mission of a leader. Second, based on the study’s results, there are characteristics and indicators of charitable leadership in the figure of KH. Zezen Zainal Abidin Bazul Asyhab. Third, the continuity and consistency of educational programs at Iqomah Nusantara as proof of the influence of KH. Zezen Zainal Abidin Bazul Asyhab is a charismatic leader, even though he has passed away.
THEMATIC APPROACH TO AZIM SUYUN’S POEMS
Authors: YILMAZ Tuğba
Published: January 2023

Azim Suyun was born on February 22, 1948 in the village of Nakurt, in the province of Samarkand, Uzbekistan. He is known for his works in the genres of story, drama, epic, poetry and translation in Uzbek Literature. In addition to his; he has many works written about poetry and poet. The poet is one of the important figures of Uzbek Literature in the Soviet and Independence Period. Azim Suyun did not remain indifferent to the problems of the age in which he lived, and dealt with the existing troubles and the events he personally witnessed in his works. At the same time, the poet drew attention to the unique beauties of the geography he lived in after mentioning the historical importance of the ancient cities of Uzbekistan.   Between 1978 and 2020, Azim Suyun came to the forefront with his works written on many subjects such as love, nature, family, homeland, nation, independence, language, religion, goodness, philosophy, historical and literary figures, poets and poetry, criticism and so on. In the study, after the subjects that the poet mainly deals with in his poems are mentioned, his works are examined thematically. It covered classified under eight headings as “Poems About Homeland and Nation”, “Literary Personalities”, “Poems About Poet”, “Criticism Poems”, “Poems on Religious Subjects”, “Poems About Nature”, “Poems About Seasons” and “Love Poems”. In this study, it is aimed to introduce his works by emphasizing the aesthetic power and poetic features of the poet’s poems.
A META-ANALYSIS IN DESCRIPTION AND CONTEXT DIMENSIONS INCLUDING CONSUMER BEHAVIORS INTENDED FOR SYMBOLIC CONSUMPTION
Authors: AYHAN GÖKCEK Hande
Published: January 2023

Today, it is seen that the meaning attributed to consumption has changed. In the past, while consumption within the needs came to the fore, consumption lost its rational meanings with the modern period; pleasure, status, vanity, etc. purposes can be seen. Today, consumption has become a prominent concept in the social, psychological and cultural processes of societies. Symbolic consumption is a form of consumption in which the symbolic values attributed to the products or brands that are the subject of consumption are considered in demand. In this form of consumption, which is based on the ready-made meanings that products offer to consumers, which is seen as a necessity of the postmodern period, it is necessary to gain consumer status, to determine their social class, to define their own existence, etc. may be directed towards consumption. The meaning in the consumed object is transferred directly to the consumer. This study takes into account the academic studies in Turkey and the world between the years 2021-2022; It is based on the meta-analysis of academic studies that are determined by scanning databases through the online libraries of national and international universities such as YÖK National Thesis Center, Pubmed, EBSCOhost, Web Of Science and Google Academic.
ASSESSMENT AND ASSESSMENT IN HYBRID EDUCATION: CHALLENGES AND OPPORTUNITIES
Authors: KARABACAK Ali , KARACA Şemsi
Published: January 2023

Since the beginning of the 20th century, technology and mass media have become effective in all areas of rapidly developed life. For this reason, access to information has gained diversity and speed. The inability of the current education and training methods to reach this speed has led societies to question teaching methods and materials and to new searches. As a result, a new paradigm has emerged in education. The education model that emerges as a necessity and is the subject of discussion is "distance education". In our research, content analysis was carried out within the scope of qualitative data analysis in order to evaluate the difficulties and opportunities encountered in the Measurement and Evaluation in Hybrid Education, which is a dimension of the distance education model. An interview form was applied to 30 teachers. Despite the opportunities provided by technological tools in accessing information, we think that distance education has lost its attractiveness in a very short time. For now, it does not seem possible for this method, which is used in many countries due to the Covit 19 Pandemic, to replace formal education. Providing students' attention and attention, technical problems (connection problems due to infrastructure), organizing extracurricular learning activities, preventing cheating in exams, difficulties in focusing on both the classroom and online participants at the same time in hybrid lessons. The fact that the tablets provided by the Ministry of National Education are disproportionate to the number of students and that the tablets are not compatible with the required computer programs have also made distance education difficult.
İŞ YERİ YALNIZLIĞININ ÇALIŞAN PERFORMANSINA ETKİSİ: AKADEMİSYENLER ÜZERİNE BİR UYGULAMA
Authors: ORHAN Aylin Türe
Published: January 2023

İş yerinde yalnızlık, çalışanın daha çok karakterine atfedilen özel bir sorun olarak algılandığından dolayı, genellikle yalnızlığı konu alan çalışmalar, kişisel faktörlere odaklanma eğiliminde olmuştur. Bu sebepledir ki; örgütler tarafından ihmal edilen, hatta görmezden gelinen ve literatürde de nispeten daha az ilgi gören bir konu haline gelmiştir. Tek bir coğrafyayla sınırlı olmayan, tüm dünyadaki insanları ve ekonomileri etkileyen bir olgu olarak kendini gösterebilen iş yeri yalnızlığı hem örgütler hem de çalışanlar açısından, birçok olumsuz sonuçları da beraberinde getirmektedir. Bu olumsuz sonuçların başında şüphesiz ki performans düşüklüğü başta gelmektedir. İş yerinde yalnızlık tüm çalışanları etkilediği gibi ‘’bilim insanları’’ olarak anılan akademisyenleri ve dolayısıyla da performanslarını etkilemektedir. Bu çalışmanın amacı, akademisyenlerin, iş yeri yalnızlık düzeylerinin performanslarına olan etkisini araştırmaktır. Bu amaçla İstanbul’da bulunan 23 vakıf üniversitesinde görev yapmakta olan 425 akademisyenden veri toplanmıştır. Araştırmadan elde edilen bulgulara göre; akademisyenlerin, iş yeri yalnızlık düzeyleri ile performansları arasında anlamlı bir ilişkinin var olduğu tespit edilmiş, akademisyenlerin, iş yerinde yaşadığı yalnızlık duygusu arttığında akademik performans düzeylerinin önemli ölçüde düştüğü belirlenmiştir.
Determination of Conservative Conditions of the Model of Reactivity Accident at RBMK‑1000
Authors:   Institute for Safety Problems of Nuclear Power Plants, NAS of Ukraine, Borysenko V. I. , Goranchuk V. V.
Published: January 2023

Analytical studies have been performed on the model of a reactivity accident at the 4th Unit of the Chornobyl NPP with an RBMK-1000-type reactor. The model of the RBMK-1000 reactor was developed based on the equations of nuclear reactor kinetics. In the model, the reactivity changes as a result of external influences (the movement of control rods; changes in the coolant temperature at the reactor inlet), as well as a result of feedback on reactivity effects (changes in fuel temperature, coolant density, 135Xe concentration). The change in the coolant density takes into account the formation of steam in the reactor core, and the coolant pressure is introduced into the model as an external factor, according to the results of the registered data during the accident on 26.04.1986. There is a high sensitivity of the RMBK-1000 reactivity model to the absolute values of reactivity coefficients that have occurred on the eve of the accident (negative reactivity coefficient by fuel temperature, positive steam coefficient of reactivity). Therefore, the study is conducted for different combinations of values of the efficiency of the control rods, reactivity coefficients, as well as other factors affecting the course of the accident — emergency protection triggering time, and reactor power level before the accident. Considering that the main stage of the accident lasted less than 10 s, fuel destruction is possible when the critical value of fuel enthalpy is reached, at which the fuel dispersion process begins. The results of modeling of reactivity accident on RBMK-1000 with the values of parameters of reactivity effects, which best correspond to the chronology of recorded events as well as to the recorded values of technological parameters, are presented.
Relevance of Forecasting Air Pollution of the Working Area during Performance of Works on Fragmentation of Structural Elements of the NSC-SO
Authors:   Institute for Safety Problems of Nuclear Power Plants, NAS of Ukraine, Pavlovskyi L. I. , Gorodetskyi D. V. , Derenhovskyi V. V. , Menshenin Ye. А.
Published: January 2023

The characteristics of the modern radiation situation in the areas of work under the project “Reconstruction of the Shelter object of the SSE ChNPP in the part of the dismantling of the metal truss of the southern roof reinforcement” are provided. It is shown that during the period of research and industrial operation of the “New Safe Confinement — Shelter object” (NSC-SO) complex, as a result of the sealing of its containment circuit, there was a deterioration of the radiation situation due to an increase in the amount of general and non-fixed surface pollution. The reason for this is the deposition of radioactive aerosols, which are generated both in the Shelter object and during construction work in the internal volume of the NSC-SO complex. According to research data, the average value of the total density of surface pollution by beta-active nuclides of metal structures in the areas of work under the project, for the period from 2018 to 2021, increased by 9.3 times, and the value of unfixed surface pollution by 5.7 times. Such extremely unfavorable radiation conditions encourage the widest possible use of unmanned technologies with the use of remotely controlled robot manipulators (RCRM). In the case of the impossibility of using RCRM for radiation-hazardous technological operations and their replacement by operations performed manually, it is absolutely necessary to forecast the dynamics of air pollution in the working area during the performance of such works in order to guarantee the effective application of appropriate measures for personnel radiation safety. A predictive assessment of radioactive air pollution of work zones in the internal volume of the NSC-SO complex during the execution of project work was provided, which made it possible to optimize measures for the radiation safety of working personnel, in particular, in the selection of appropriate types of means of individual protection of respiratory organs. The proposed approach can be used during the planning of further radiation-hazardous works in the internal volume of the NSC-SO complex, namely, during the dismantling of unstable structures of the Shelter object and the partial removal of nuclear materials and high-level waste from the Shelter object.
Application of the Research Method of the Angular Distribution of Gamma Radiation Intensity Using the DC-R Device
Authors:   Institute for Safety Problems of Nuclear Power Plants, NAS of Ukraine, Khomenko D. O. ,   Institute of Mathematical Machines and Systems Problems of the NAS of Ukraine,   Wolfgang Pauli Institute, Yehorov V. V. ,   Institute for Safety Problems of Nuclear Power Plants, NAS of Ukraine, Pavlovskyi L. I.
Published: January 2023

The paper presents the results of the application and verification results of the effectiveness of the method of studying the angular distribution of gamma radiation intensity using a dosimeter MKS-07 “Poshuk” with a remote detector in the collimator (DC-R). The purpose of this work is to verify the effectiveness of the method using the DС-R device on pre-known sources and to obtain an array of data in one area from different points. Before the start of the study, an analysis of available data on the radiation situation was performed. This allowed determining a sufficient number of measurements of angular distributions to verify the effectiveness of the method and the location of measurement points. As a result of the analysis of the initial data from the radiation state, it was decided to investigate the area of the Shelter object from the west to the east. Known source in the blockages of the central hall of of the Chornobyl Nuclear Power Plant Unit 4 of the Shelter object are located in this zone. The obtained measurements results of the quantitative characteristics of the angular distribution of gamma radiation intensity are presented graphically. As a result of the study of the angular distribution of gamma radiation intensity using the DC-R device, the high efficiency of source recognition was proved even in conditions of high gamma fields. After processing the obtained results and their analysis, the following conclusions were formulated: 1. The effectiveness of this method in the study of the angular distribution of gamma radiation intensity has been confirmed. This is seen when comparing points K1 and K3. 2. A hitherto unrecorded source of ionizing radiation was found, which forms a radiation state at the study site, which corresponds to point K2. 3. It is confirmed that in high fields of ionizing radiation this method is inappropriate in connection with the receipt of personnel of high dose loads during research. 4. Background values were recorded in the directions with no radiation sources, so they are not reflected on the cartograms. This is due to the fixation of gamma rays by the detector passing through the lead walls of the collimator. This proves the effectiveness of shielding the detector from powerful sources and allows it to be used in high fields.
Análisis contrastivo entre el gerundio en español y la partícula aspectual 着 (zhe) en chino
Authors:   Universidad de Estudios Internacionales de Zhejiang, Chen Zhengyang
Published: January 2023

Este trabajo presenta un análisis contrastivo de dos elementos lingüísticos: el gerundio del español y la partícula aspectual 着 (zhe) del chino. Para abordar la problemática de la comprensión y el uso del gerundio en español, los estudiantes chinos suelen recurrir a categorías de palabras semejantes al gerundio de su lengua materna o del inglés. En su aprendizaje de español, el equivalente natural para la comprensión del gerundio lo protagoniza la partícula aspectual 着 (zhe), ya que comparte el significado aspectual imperfectivo. De esta forma, en el presente estudio nos proponemos contrastar estos dos elementos lingüísticos a través de sus características morfológicas, sintácticas y semánticas, con el propósito de alcanzar un resultado práctico que asista a los alumnos chinos en su adquisición del español como segunda lengua extranjera.
OPTIMIZATION OF PROGRAM OF COLORECTAL CANCER SCREENING IN SAMARA REGION
Authors:   Samara Regional Clinical Oncology Center, Orlov A. E. , Kaganov O. I. ,   Samara Regional Clinical Oncology Center, Babanov S. A. ,   Samara State Medical University, Frolov S. A. ,   Samara Regional Clinical Oncology Center, Somov A. N. ,   Samara Regional Clinical Oncology Center, Okuneva I. V. ,   Samara Regional Clinical Oncology Center, Kozlov A. M. ,   Samara Regional Clinical Oncology Center
Published: January 2023

In Samara region colorectal cancer has taken a leading position in the structure of the incidence of oncological diseases in recent years. The aim of the study is to optimize preventive work in the region aimed at preventing the development of colorectal cancer and improving the detection of this disease at early stages. Material and methods. In addition to the activities provided by the program of dispanserisation of the adult population, the oncological service of the region proposed a number of organizational solutions: the program «Men’s health» was introduced, the target audience of which was men 40-60 years old; the programs of examinations at manufactures and offices of the region, carried out by the regional center of pathology associated with the profession, have been optimized; active educational activities are carried out by the department of medical prevention of the regional oncological center. Results. The introduced approaches allowed increasing the coverage of the population with preventive examinations and increasing the number of patients with diagnosed colon polyps. Extremely important is the work aimed at shaping the ideology and motivation of the population to actively maintain health.
AKT INHIBITOR POTENTIATES CYTOTOXIC ACTIVITY OF DOXORUBICIN IN OSTEOSARCOMA CELLS IN VITRO
Authors:   Kazan State Medical University, Boychuk S. V. , Galembikova А. R. ,   Kazan State Medical University
Published: January 2023

Activation of receptor and nonreceptor tyrosyne kinases (TK) is detected in a broad spectrum of human malignancies, including soft tissue sarcomas (STS) and osteosarcomas (OS) and in some cases correlates with poor prognosis and clinical outcomes. Despite the topoisomerase II inhibitor doxorubicin is broadly used for treatment of STS and OC as mono- and as a component of the combined chemotherapeutic regimens, rapid development of tumor resistance to doxorubicin is considered to be most significant factor of poor prognosis and bad clinical outcome, especially for the patients with metastatic and reccurent forms of disease. This, in turn, remains a driving force to develop novel effective approaches to increase sensitivity of tumor cells to this chemotherapeutic agent and overcome drug resistance. Our current data illustates activation of c-Met-, FGFR-, AKT-, и МAPK-kinases in OS cells, whereas inhibition of their activities with corresponding TK inhibitors (TKIs) (crizotinib, BGJ398, MK-2206, and U0126, respectively) enhances cytotoxic activity of doxorubicin against OS cells. The most prominent synergism between doxorubicin and TKIs inhibitors was found for AKT inhibitor MK- 2206. We found that MK-2206 significantly enhanced sensitivity of OS cells to doxorubicin and induced their apoptosis. Thus, activation of AKT signaling in OS might be an attractive therapeutic target to increase OS sensitivy to chemotherapeutic agents, in particular, doxorubicin. This in turn provide the molecular basis for the effective further use of the combined (AKT- and topoisomerase II inhibitors) therapy for patinets with OS.
EXPERIENCE OF USING PEMBROLIZUMAB IN THE TREATMENT OF LOCALLY ADVANCED RECURRENT SQUAMOUS CELL CARCINOMA OF THE LARYNX. CLINICAL CASE
Authors:   Republican Clinical Oncology Dispensary, Musin Sh. I. , Sultanbaev A. V. ,   Republican Clinical Oncology Dispensary, Menshikov K. V. ,   Republican Clinical Oncology Dispensary, Zamilov M. M. ,   Republican Clinical Oncology Dispensary, Sultanbaeva N. I. ,   Republican Clinical Oncology Dispensary, Menshikova I. A. ,   Bashkir State Medical University, Lipatov D. O. ,   Bashkir State Medical University
Published: January 2023

One of the most problematic nosologies among squamous cell carcinoma of the head and neck is cancer of the larynx. Until now, the therapy for squamous cell carcinoma of the head and neck has remained unchanged and is based on combinations with platinum-containing therapy. One of the promising areas for the treatment of common tumors is immunotherapy. The results of the KEYNOTE-040 study indicate the possibility of prolonging disease control after disease progression on first-line platinum-containing chemotherapy. This publication analyzes a case of treatment with the checkpoint inhibitor — Pembrolizumab. After platinum-containing chemotherapy, immunotherapy in the 2nd line made it possible to achieve tumor control in the form of a partial response within 17 months of therapy. As a result of treatment with pembrolizumab, an adverse event was not registered in a patient.
CANCER OF THE PARATHYROID GLANDS. CLINICAL OBSERVATION
Authors:   Izhevsk State Medical Academy, Soloveva A. N. , Lozhkin E. A. ,   Republican Clinical Oncology Dispensary, Kiryanov N. A. ,   Izhevsk State Medical Academy
Published: January 2023

An example of parathyroid cancer with a reliable pathomorphological picture, signs of invasive growth and vascular invasion is given. The immunohistochemical profile of the tumor is presented, which made it possible to determine the degree of malignancy of this neoplasm. It was shown that the development of the tumor was accompanied manifest bone form of hyperparathyreosis. Timely diagnosis and removal of the tumor led to positive results, and after a few years the patient feels satisfactorily.
Cardiac rehabilitation in coronary artery bypass grafting patients: Effect of eight weeks of moderate-intensity continuous training versus high-intensity interval training
Authors: Shafiee Neda , Kordi Negin , Gadruni Keivan , SalehFard Ziba , Jung Friedrich , Heidari Naser
Published: January 2023

BACKGROUND:

Physical training in patients with heart failure can affect hemodynamic, cardiac and angiogenesis parameters.

OBJECTIVE:

The aim of the present study was to investigate the effects of traditional moderate-intensity rehabilitation training and interval training on some angiogenesis factors in coronary artery bypass graft (CABG) patients.

METHODS:

Thirty CABG patients (mean age±SD, 55±3 years) were randomly assigned to one of three groups: high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) or the control group. After the initial assessments, eligible patients in the experimental groups (HIIT and MICT) performed exercise training for 8 weeks, while the control group did not. Angiogenesis and angiostatic indices, including pro-adrenomedullin (pro-ADM), basic fibroblast growth factor (bFGF), and endostatin, were then measured.

RESULTS:

The results showed no significant difference between pro-ADM in the HIIT and MICT groups ( P = 0.99), but a significant difference was found between MICT and the control group and between HIIT and the control group ( P = 0.001). There is also no significant difference between the bFGF levels in the HIIT and MICT training groups ( P = 1.00), but the changes in this factor between the training groups and the control group were significant ( P = 0.001). There was a significant difference between the levels of endostatin in all three groups.

CONCLUSIONS:

Two methods of cardiac rehabilitation (HIIT and MICT) may be useful for the recovery of patients with coronary artery bypass grafting. This improvement manifested itself in changes in angiogenesis and angiostatic indices in this study. However, more extensive studies are needed to investigate the effects of these two types of rehabilitation programs on other indicators of angiogenesis and angiostatic.
Automatic Imagery Coloration and Regenerative Design of Ethnic Costume
Authors: Cao Jingwen , Lin Ruibing , Xu Pinghua , Jia Jing , Xu Minghui
Published: January 2023

The imagery colors of traditional ethnic costumes are unique and have great reference value for modern design. In this paper, 3 representative minority costume images of Miao, Tibetan, and Korean were respectively selected as imagery sources, and 20 different structure types of patterns were chosen as the object to be colored. Image pre-processing, adaptive color extraction, and multi-dimensional features extraction were executed to build a color nexus network model. Based on the color parsing results, an algorithm for color migration of clothing images was designed and developed, which could output multiple types of color schemes. The overall rating of each color scheme was compared to introduce the optimal scheme. Also, the experimental part tested the effect of the color schemes in various scenarios. The average pre-processing time cost of a single image is 0.05 seconds, the output time of the color network diagram is 0.38 seconds, and the output time of a single-color scheme is 1.44 seconds. The study can quickly provide an auxiliary decision for contemporary pattern color design.
Texture Characteristics Parsing of Basic Stitch in Simulation Embroidery
Authors: Shi Wenhui , Ni Jialu , Xu Pinghua , Sun Xiaowan , Cai Na
Published: January 2023

In order to fast identify and realistic simulate embroidery art, the respective texture characteristics of basic stitch in Simulation embroidery were extracted and preferred. Concretely, three feature extraction methods – gray co-occurrence matrix method (GLCM), Tamura method and gray difference statistics method (GDS), are combined to extract the features of embroidery needlework, and the best respected characteristics were compared and verified. Results shows that the best feature combination of needle texture in this paper is energy standard deviation, energy mean, standard deviation of moment of inertia, and mean of moment of inertia, which is defined as energy-moment of inertia feature. The proposed method effectively solves the inaccurate problem with single feature in the recognition of needle texture features, can be help for needlework recognition and virtual simulation.
Cultural Derivatives of Exhibition Materials from the Perspective of Information Flow Design Innovation Research
Authors: Chen Yunjia , Sun Wenxi
Published: January 2023

Art exhibitions are for promoting social aesthetic education. As the information carrier of exhibition culture, exhibition materials play a role in the dissemination of aesthetic education between the tangible and the intangible. Based on the long-life design philosophy, the textual research continued the exhibition’s lifecycle through innovative creative design after the exhibition. Reconstructing the design symbols of cultural derivatives guided the development of cultural derivative design experiments with PVC inkjet cloth as the object. The evolution from “waste product” to “product” and then to “commodity” was completed, which opened up an innovative path for exhibition culture to further enhance social aesthetic education, while also broadening the opportunities for researchers engaged in long-life design and green design.
Fabric Preparation of Stab-Resistant Functional Clothing
Authors: Shi Yajing , Yan Taohai , Lai Wanni , Lu Dongdong , Lin Chaowang
Published: January 2023

As a kind of protective clothing, anti-stab clothing is also known as anti-knife clothing, which has the functions of anti-cutting, anti-stabbing, wear resistance and anti-theft. Ultra-high molecular weight polyethylene (UHMWPE) has good wear resistance, tear resistance, cutting resistance, impact resistance, light resistance and other excellent properties, can resist acid and alkali corrosion, continuous friction, UV resistance, in various harsh environments It can withstand the test and is one of the high-quality fibers commonly used in stab-resistant clothing. In this paper, ultra-high molecular weight polyethylene (UHMWPE) is mainly used to prepare high-strength knitted fabrics and woven fabrics. Plain, twill and satin fabrics are used in woven fabrics, and 1+1 rib and plain knitted fabrics are used in knitted fabrics.
Enpowering Diet Management Happy and Sustainable via Positive Design Method
Authors: Liu Zhiqi , Xu Juanfang , Liu Zheng
Published: January 2023

Diet management has become a common concern in daily life. Most of the current related designs provide accurate calorie estimates and personalized diet recommendations, which does not touch the core of management – how to make this behavior active and sustainable. This study introduces the concept of Positive Design, constructs a three-step design path which is applied in practice, aiming to give long-term happiness to diet management and promote users’ active adherence. The vital step is to invite target users and designers to join in collaborative work, identify and filter eight conflict dilemmas which are worthy of study. Positive design is a new theoretical perspective based on positive psychology. The final scheme produced in this paper aims to explore the application of this method in diet management design, and also provide a certain reference for subsequent research.
Similar Image Retrieval Algorithm Based on Feature Fusion and Locality-Sensitive Hash
Authors: Zhang Kaiqiang , Li Wei , Yu Shaoyong , Chen Shunyi , Zeng Zhiqiang , Ma Xiaoyu , Luo Youmeng
Published: January 2023

In this paper, we propose a similar image retrieval algorithm based on feature fusion and locality-sensitive hash to address the problems of inadequate representation of image content by individual features and long retrieval time for massive image data. The fusion of global features and attention features makes the image features have both color structure and semantic information, which can better characterize the image content. In the image retrieval stage, the locality-sensitive hash is used to hash encode the image features, the cosine similarity is used as the similarity measure, and finally, the index is built to improve the retrieval efficiency. The similar image retrieval algorithm proposed in this paper has improved the average finding accuracy and recall rate on Caltech 256 and Corel5k datasets compared with other methods, and the retrieval time is greatly reduced.
Research on Visual Perception of Gender Identification Elements in Water Cup Design
Authors: Wang Zuolong , Yin Hang
Published: January 2023

In light of the market trend of using design means to guide enterprise resource allocation in order to improve efficiency, this paper investigates the consumer’s gender perception of water cup design elements using morphological analysis and analytic hierarchy process, and verifies the difference of priority among design elements in the process of consumer’s perception, and each design element has different influence weights in consumer’s gender perception recognition. The research contributes to the transmission of experience in gender-differentiated water cup design and creates efficiency advantages for enterprises competing in the gender-differentiated cup market.
Optimal Design of Book Listening Machine for Visually Impaired Group
Authors: Yan Yan , Zhang Fang , Liu Yi
Published: January 2023

The paper analyzes that we study the reading paths and preferences of visually impaired groups, compare the current situation of audiobooks for visually impaired groups on the market, analyze the pain points of volume and font adjustment and unreasonable button design that users encounter when using such audiobooks, and base the product design on handheld portable audiobooks to find out The product design is based on the handheld portable dictaphones, and the feature that people will change the distance between the product and themselves according to the volume and the size of the pictures, and add the sensor that can measure the distance between the human face and the dictaphones to realize the adaptive adjustment of the font and volume according to the change of the distance, and finally produce the product prototype to achieve the purpose of intelligent adjustment of the volume and font.
Guzheng Fingering Practice Assistant System Based on Gesture Recognition: Supporting Practice by Providing Feedback
Authors: Zhou Zixin , Liu Zheng
Published: January 2023

Beginners need a lot of practice to master fingering as a motor skill. However, in the post-lesson practice sessions, beginners often fail to provide internal feedback due to a lack of proper long-term memory, which ultimately leads to high error rates and poor practice results. This paper proposes a system to assist in the practice of Guzheng fingering. By constructing three corresponding student types and feedback implementation scenarios to provide different types of augmented feedback, the system aims to better support beginners in practicing Guzheng fingering on their own. The system employs gesture recognition technology to support the feedback intervention, and positive results were obtained through comparative experiments in which the system’s recognition and judgement functions could be used.
Texture feature dimensionality reduction-based mammography classification using Random Forest
Authors: Zhang Xuejun , Zhang Susu , Bu Zhaohui , Ma Liangdi , Huang Ju
Published: January 2023

Breast cancer is the most frequent cancer and the leading cause of death among females. Diagnosis mass from mammogram correctly can reduce the unnecessary biopsy to a large extent. In this paper, we present a novel mammogram classification method combining the Random Forest and the Locally Linear Embedding (LLE) dimensionality reduction algorithm for texture features. The proposed method consists of three stages. In the first stage, preprocessing is performed to enhance the contrast and suppress the noise of the ROI images. Then, the sixteen-dimensional texture features are extracted from Grey Level Co-occurrence Matrix (GLCM) as the input dataset of LLE and being mapped into a five-dimensional subspace. Finally, a Random Forest classifier is investigated for the mammogram classification and compared with the other four classifiers (SVM, KNN, Logistic Regression, MLPC). The experimental results show that the Random Forest classifier outperforms than the others, with an average accuracy of 92.87% and the AUC value of 0.99, that indicates that the combination of LLE algorithm and Random Forest classifier is a promising method for the mammogram classification.
Estimating a time series of temporary employment using a combination of survey and register data
Authors: Mushkudiani Nino , Pannekoek Jeroen
Published: January 2023

In this paper we investigate the application of macro-integration methods to combine two sources of labor force statistics: a survey and an administrative source. In particular, we aim to arrive at a single estimate of the time series of temporary employment that efficiently combines the information from both sources. By varying the specifications of the objective function and constraints, four different macro-integration models were defined. The most plausible results were of a model that treats neither of the sources as fixed and uses multiplicative adjustments. The results were compared with the previous research where a latent Markov model was used to estimate the same time series. This Markov model approach does not lead to very different estimates of the time-series of temporary (or permanent) employment contracts but results in smaller estimates of the proportion of “movers”, persons that change contract status from temporary to permanent or the other way around. The model-based approach also provides estimates of the measurement errors in each of the sources. On the other hand, the macro-integration approach is less restrictive in the sense that it does not impose a Markov property of the integrated times series of proportions and it is more easy to implement.
Teaching fire safety through design-based immersion of National Building Code-2016 provisions to students of undergraduate architecture: a student feedback on the pedagogy technique
Authors: Singh Raja
Published: January 2023

This study is based on the feedback received from students of 3rd year Architectural undergraduate degree at a leading architectural education college in India. This degree in India leads to a professional license to practice as an architect in India. The study tests the design based immersive integration of National Building Code 2016 and its fire provisions into the curriculum in order to overlay fire safety interventions on design projects familiar to students. The detailed course pedagogical structure has been presented. For feedback, an 11 point questionnaire was circulated which was answered by 32 students in anonymous mode in order to prevent any conflict of interest. The results show an overall positive response where the students prefer a design integration based fire safety curriculum which introduces fire codes to the students in the applied format.