bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-145 regulates the proliferation of the human gastric cancer cells by targeting tuftelin 1 (TUFT1)
Authors: Meng Pei , Xia Ronglong , Shao Zhihong
Published: May 2022

MicroRNA-145 (miR-145) has been shown to regulate the development of different human cancer. However, the role of miR-145 via modulation of tuftelin 1 (TUFT1) expression has not been studied in gastric cancer. TUFT1The results showed that gastric cancer tissues and cell lines exhibit significant (P<0.05) downregulation of miR-145. Overexpression of miR-145 significantly (P<0.05) inhibited the viability and colony formation of the MGC-803 gastric cancer cells. Annexin V/PI staining revealed that miR-145 exerts its tumor-suppressive effects via induction of apoptosis. The apoptotic cell percentage increased from 5.75% in negative control to 22.95% in miR-145 overexpressing MG-803 cells. This was also accompanied by upregulation of Bax and downregulation of Bcl-2 expression. TargetScan analysis and the dual luciferase assay revealed TUFT1 as the functional target of miR-145. The expression of TUFT1 was significantly (P<0.05) upregulated in gastric cancer tissues and cell lines. However, overexpression of miR-145 causes inhibition of the TUFT1 expression. Silencing of TUFT1 mimicked the tumor-suppressive effects of miR-145. However, tuftelin 1 overexpression attenuated the tumor-suppressive effect of miR-145 in MGC-803 gastric cancer cells. Taken together, the results of the present study indicate that miR-145 targets TUFT1 at translational level to exert its tumor suppressive effects in gastric cancer.
Proteomics analysis of lipid droplets in mouse neuroblastoma cells
Authors: Wang Weiyi , Guan Jiahao , Zong Yu , Zhang Qiuxian , Zhang Wei , Wang Hecheng
Published: May 2022

Lipid droplets (LDs) are intracellular droplets containing phospholipids and neutral lipids. It is well known that LDs are organelles with a rich proteome. In the nervous system, these droplets may play an important role in maintaining the normal physiological function of nerve cells. Moreover, LDs may relate to the neurodegenerative disorders, such as Alzheimer’s disease (AD). However, more information is still needed about the function of LDs. In the study presented here, we identified the protein composition of mouse neuroblastoma (N2a) cell LDs using immunodetection and high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). Seventy three LDs proteins were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to investigate the potential functions of these proteins. Subsequently, the relationships among the proteins were analyzed by constructing a protein-protein interaction (PPI) network. N2a cell LDs contain multiple Rab GTPases, chaperones, and proteins involved in ubiquitination and transport. Some of these proteins were known to modulate LD formation and were related to the function of nerve cells. This work presents the proteome of N2a cell LDs and will help to identify the role of LDs in the nervous system.
Self-Efficacy and Professional Development: An Investigation of Music Teachers in Primary and Secondary Schools in China
Authors: Wen Li , Manoharan Pravina , Xuerong Cui
Published: May 2022

In an era where teachers are increasingly expected to perform at their level best, issues of self-efficacy and professional development continue to be an area of continuous debate. A random sample of primary and secondary school teachers in five cities in mainland China was selected to respond to the self-evaluation questionnaire, and 300 valid questionnaires were collected. The research was carried out to (1) investigate the levels of self-efficacy of music teachers in primary and secondary schools, (2) determine the factors that influenced music teachers' self-efficacy, and (3) explore the relationship between teachers’ self-efficacy and professional development. The data were analysed using descriptive statistics, T-test, analysis of variance, and regression. First, the results showed that the mean value of music teachers’ self-efficacy was 7.16. Second, the middle school teachers reported lower self-efficacy compared to teachers in the primary schools. Third, although teachers aged between 20 to 50 years old reached their highest level of self-efficacy, it decreased to a lower value after an extended period. Additionally, the study also revealed a significant difference in self-efficacy among teachers with different teaching experiences. Although educational backgrounds, gender, and training hours did not influence self-efficacy, a positive correlation was reported between self-efficacy and professional development. Prospective research might better consider developing music teachers’ self-efficacy and education across primary and secondary schools.
Teleworking and Its Effects on Health during the Covid-19 Pandemic
Authors: Pazhoohesh Negin , Kouhnavard Bahram
Published: May 2022

The Article Abstract is not available.
COVID-19 Surveillance in Workplaces: a Success Story of Surveillance in Migrant Workers in Brunei Darussalam
Authors: Lai Alice , Trivedi Ashish , Ishak Norzawani , Ahmad Norzalena , Omar Nurasiah
Published: May 2022

Background: Migrant workers are at a high risk of exposure to COVID-19 due to their work and residential status. Surveillance for SARS-COV-2 in this group is important for early detection of infection and breaking the chain of disease transmission in the workplace and community. This report describes an enhanced active surveillance strategy for COVID-19 in migrant workers of Brunei Darussalam during the first wave of the outbreak in 2020. Methods: Active and phased surveillance of migrant workers for SARS-CoV-2 was conducted by the Ministry of Health on a total of 9443 workers, in 2020. Surveillance was carried out using a nasopharyngeal swab test for SARS-CoV-2 reverse transcription-polymerase chain reaction (RT PCR) in phases I and II, whilst a rapid antigen test was used in phase III. Results: Phase I included 7073 workers from 714 workplaces; phase II covered 860 workers from 190 workplaces; and phase III covered 1510 workers. Three positive cases were detected during phase I of the surveillance. No migrant worker was tested positive for SARS-CoV-2 during the second and third phases of surveillance. Conclusion: The number of positive cases detected was small; however, this strategy actively searched for the presence of SARS-CoV-2 among the migrant worker population in the country, and further confirmed the absence of any hidden local transmission of cases in this population.
Analiza frekwencji w polskich atrakcjach turystycznych
Authors: Kruczek Zygmunt
Published: May 2022

Atrakcje turystyczne są ważnym segmentem rynku turystycznego, odgrywają ogromną rolę w kształtowaniu geografii ruchu turystycznego, pomimo to badania nad atrakcjami są stosunkowo rzadko podejmowane. W artykule zawarto wyniki badań nad frekwencją w różnego rodzaju atrakcjach w Polsce wraz z próbą identyfikacji czynników determinujących ich popularność mierzoną liczbą odwiedzających. Wyróżniono atrakcje flagowe, mające znaczenie dla tożsamości i wizerunku regionów.
Zastosowanie „metod mieszanych” do badania zachowań turystów w mieście – przykład konceptualizacji i wykorzystania (artykuł dyskusyjny)
Authors: Kotus Jacek , Rzeszewski Michał
Published: May 2022

Opracowanie mieści się w kategoriach konceptualno-metodologicznego artykułu dyskusyjnego. Celem pracy jest dyskusja na temat zastosowania „metod mieszanych” (mixed methods research) w polskich badaniach turystycznych, w szczególności zachowań turystów w mieście. Artykuł składa się z części omawiającej zestaw metod wykorzystanych do badania zachowań turystów oraz prezentującej wyniki badań – zastosowania zaproponowanego algorytmu postępowania. Autorzy przyjmując podejście behawioralne proponują zastosowanie metody quasi-eksperymentu połączonego z wykorzystaniem technik rejestracji ruchu GPS oraz metod jakościowych badań socjologicznych. W opracowaniu podejmuje się dyskusję literaturową dotyczącą tzw. mixed method research, omawia zaproponowany algorytm postępowania badawczego oraz wyciąga wnioski wynikające z zastosowania tego typu metod łącznie.
Reżim międzynarodowego partnerstwa publiczno-prywatnego na rzecz intensyfikacji współpracy między Ukrainą a Polską w sferze naukowej, technicznej i innowacyjnej
Authors: Liashenko Viacheslav , Petrova Iryna
Published: May 2022

Analizowane są europejskie doświadczenia PPP w sferze naukowej, technicznej i innowacyjnej. Ustalono, że rolą państwa jest wspieranie rozwoju wiedzy podstawowej i złożonych technologii o charakterze strategicznym, tworzenie infrastruktury i sprzyjającego klimatu dla innowacji, a biznesu - w tworzeniu technologii opartych na własnych badaniach i rozwoju rynku innowacji. Proponuje się wprowadzenie reżimu międzynarodowego partnerstwa publiczno-prywatnego w celu zintensyfikowania współpracy między Ukrainą a Polską w sferze naukowej, technicznej i innowacyjnej. Uwzględniono elementy systemu międzynarodowego partnerstwa publiczno-prywatnego. Ustalono, że reżim międzynarodowego partnerstwa publiczno-prywatnego pozwoli na ustanowienie udziału międzynarodowych instytucji finansowych, władz publicznych, uczelni/instytucji badawczych oraz biznesu we wspólnym finansowaniu projektów w zakresie działalności naukowej, technicznej i innowacyjnej Ukrainy i Polski.
Економічне підґрунтя деолігархізації в Україні
Authors: Kolosov Andriy
Published: May 2022

Na Ukrainie, która pozostaje na ostatnim miejscu w Europie pod względem produktu krajowego brutto (PKB), pojawiły się kontrowersje dotyczące przezwyciężenia oligarchii jako najważniejszego problemu systemowego w stosunkach gospodarczych w kraju. Właśnie z powodu monopolu struktur oligarchicznych w energetyce na Ukrainie nie jest możliwe dokończenie reformy rynku energii, kiedy interesy firm monopolistycznych są zdominowane przez interes publiczny, niszcząc ustalone fundamenty do wprowadzenia relacje rynkowe. W odróżnieniu od oligarchii w Polsce, w której bogaci Polacy albo dorobili się fortuny, albo założyli rodzinny biznes, ukraińscy oligarchowie ukształtowali się w wyniku nieudolnej prywatyzacji majątku przedsiębiorstw państwowych w najważniejszych sektorach gospodarki, w szczególności w sektorze energetycznym. Najbardziej zagrażający jest ogromny wpływ firm oligarchicznych na Ukrainie na podejmowanie decyzji państwowych, a także ciągła chęć wykorzystania możliwości budżetu państwa na ich korzyść.
Oligarchiczna struktura ukraińskiej gospodarki powstała w wyniku niedociągnięć przeprowadzonej w kraju prywatyzacji, której faktycznym skutkiem było pozbawienie państwowej własności majątku przedsiębiorstw na rzecz niepaństwowego kapitału. Rząd pozostawił bez kontroli dalszy skup sprywatyzowanych przedsiębiorstw i ich udziałów, tworząc podstawy do powstania gospodarki oligarchicznej, czemu sprzyjała dość wysoka monopolizacja głównych sektorów ukraińskiej gospodarki podczas jego pobytu w Związku Radzieckim. Takie warunki początkowe uprościły tworzenie oligarchicznych korporacji jako monopolistów w niektórych sektorach gospodarki, a pomoc organów państwowych w tym procesie utorowała drogę do łatwego tworzenia pionowych kompleksów przemysłowych należących do oligarchów. W toczących się kontrowersjach dotyczących formułowania przepisów o deoligarchizacji kraju należy wziąć pod uwagę, że oprócz przezwyciężenia wpływu oligarchii na media i politykę, konieczna jest poważna reforma struktury własnościowej w najważniejszych sektory gospodarki w celu przezwyciężenia w nich monopolu i stworzenia równych warunków konkurencji między podmiotami gospodarczymi o różnych formach własności.
Допомога міжнародних благодійних організаційу відновленні Донбасу як складова інтеграції України до Європейського Союзу
Authors: Калінін Олексій , Решетов Михайло , Chebotarov Viacheslav
Published: May 2022

Proponowany artykuł w kontekście orientacji Ukrainy na integrację europejską zawiera przegląd miejsca i roli małych i średnich przedsiębiorstw w kompleksie rolno-spożywczym, dążenia do jego odtworzenia i rozwoju jako sposobu na przezwyciężenie konfliktu zbrojnego w Donbasie oraz udział organy państwowe i międzynarodowe organizacje charytatywne. Za pomocą metody analizy PEST przeanalizowano otoczenie zewnętrzne MŚP w sektorze rolno-spożywczym obwodów ługańskiego i donieckiego. Podkreśla się perspektywy i znaczenie nawiązywania i rozwijania współpracy z międzynarodowymi organizacjami charytatywnymi. Podkreślono potrzebę nowego podejścia do rozwiązywania istniejących problemów oraz aktywnej i wyważonej polityki regulacyjnej państwa w zakresie rozwoju MSP, uwzględniając specyfikę sektorową i regionalną tego sektora gospodarki, co podniesie rolę MSP w życiu gospodarczym.
Особливості формування та реалізації стратегічних пріоритетів забезпечення безпеки та розвитку України та Республіки Польща
Authors: Novikova Olga , Pankova Oksana
Published: May 2022

Określone zostają specyficzne cechy kształtowania i modyfikacji modeli bezpieczeństwa narodowego Ukrainy i RP, ujawnia się treść ram prawnych określających strategie bezpieczeństwa i rozwoju tych państw. Uzasadniono celowość wypracowania nowej istoty i struktury dokumentów strategicznych, które zapewniają rozwój społeczny oraz gwarancje bezpieczeństwa człowieka, społeczeństwa i państwa. Określono aspiracje i priorytety polityki państw w zakresie ich integracji z Europejskim Środowiskiem Bezpieczeństwa i NATO.
La defensoría del pueblo del Perú y el significado de sus recomendaciones
Authors: Luque Mogrovejo Rolando
Published: May 2022

Las defensorías del pueblo son instituciones que investigan para defender derechos. Los resultados de sus investigaciones producen por lo menos estos dos efectos: la constatación de los derechos afectados o puestos en riesgo, y el planteamiento de recomendaciones para introducir cambios positivos en la conducta funcional, las normas o las políticas públicas. Pero, por el tratamiento que reciben de parte de las entidades estatales, no parece estar clara la naturaleza de una recomendación ni su trascendencia y menos las obligaciones que frente a ellas tienen las autoridades a las que son enviadas. Este ensayo se aproxima al lenguaje y al significado de las recomendaciones, a su carácter “no vinculante”, y a la ruta que debería seguir para su cumplimiento, su discusión y el uso de medios complementarios para asegurar que la defensa de derechos continúe. La base del análisis es fundamentalmente el trabajo realizado por la Defensoría del Pueblo del Perú, y la experiencia del autor en esta institución.
La precariedad del empleo público peruano en la contratación
Authors: Canessa Montejo Miguel F.
Published: May 2022

El debate político pone el énfasis en las tareas que debe cumplir el Estado frente a la crisis sanitaria y económica, sin valorar si los servidores públicos que laboran en el Estado tienen las capacidades y las habilidades para en-frentar esas tareas. Se asume que el Estado peruano está en condiciones de implementar políticas públicas desde la improvisación. En realidad, esto evidencia un desconocimiento real sobre las condiciones laborales del empleo público. A su vez, los laboralistas reducimos el análisis a la exégesis de la regulación y la recopilación de las sentencias judiciales o las resoluciones de la Autoridad Nacional del Servicio Civil (Servir), sin vincular la regulación y las estadísticas que miden los indicadores del em-pleo público, de modo que dejamos de lado dicha conexión o, inclusive, reducimos las propuestas normativas a una mera abstracción jurídica sin correspondencia con la realidad y sus consecuencias que afectan a los servidores públicos. En el presente artículo se analiza los regímenes laborales públicos y el impacto de su aplicación en la estructura del empleo público, con ello vinculamos la descripción de la regulación y los resultados estadísticos, presentando u panorama socio-jurídico del empleo público peruano.
Assessing the Nutrient Status of Soil and Water Bodies in Palayapatti Areas, Thanjavur District of Tamil Nadu (India)
Authors: Selvaraj S.
Published: May 2022

Background: Thanjavur is a cauvery delta zone for paddy growing area of Tamil Nadu. The current study aiming with understanding about chemical properties and nutrient status of soils of selected area and assessing quality of water bodies. Methods: The study was conducted during 2018-19 at Palayappatti and its surrounding villages in Thanjavur district of Tamil Nadu to find out the nutrient status of soil and water. Fifty representative soil samples and ten water samples collected with the objectives of analyzing chemical properties of soil and assessing water quality in Palayapatti and its surrounding villages of Thanjavur district. Result: The collected soil and water samples varied with different chemical and physical properties. Soils were slightly acidic to slightly alkaline, normal EC and low organic carbon, low to medium content of nitrogen, phosphorus and potassium, low to medium content of calcium, magnesium and sulphur. Water samples were slightly acidic to moderately alkaline pH, medium to high salt content, moderate amount of carbonate and bicarbonate content. The soil and water bodies of this land having medium range of nutrients and also improvement is need in water quality.
Effect of Leptin and IGF-I Supplementation on in vitro Maturation and Expression of Apoptotic Genes in Goat Oocytes
Authors: Quadri Saleema Ahmedi , Shukla Satya Nidhi , Singh Ajit Pratap , Sarkhel Bikash Chandra
Published: May 2022

Background: The quality of gametes is a crucial factor for the successful development of an embryo. The potential of oocyte development is acquired during oogenesis by many changes at the molecular and cellular levels. The present study explores the effect of leptin and IGF-I supplementation on in vitro oocyte maturation and the expression of apoptotic genes in matured goat oocytes. Methods: In vitro maturation of abattoir-derived oocytes was in maturation media having supplements as the group I (control), group II (leptin 20 ng/ml) and group III (IGF-I 100 ng/ml). From these oocytes, RNA was isolated and expressions of apoptotic genes were studied. Result: There was no significant difference found between cumulus expansion and also in nuclear maturation in groups I, II, III. The relative expression of BAX gene was 0.65 fold lower in group II and 0.42 fold lower in group III as compared to group I whereas relative expression of Mcl-1 gene was 2.55 fold higher in group II and 0.31 fold lower in group III as compared to group I.
​​Selecting Stable Chickpea Genotypes under Rainfed Cultivation using GGE Biplot Analysis
Authors: Srivastava A.K. , Mondal B. , Jha U.C. , Singh Archana , Biradar Revanappa S. , Praween Nagmi , Singh Nandan , Dixit G.P. , Kumar Yogesh
Published: May 2022

Background: Large environmental influence has been observed on grain yield in rainfed chickpea resulting in higher yield instability. Besides per se performance, stability of chickpea genotypes is a key trait for assured yield under rainfed cultivation. The present study evaluates chickpea advanced breeding lines for stability of grain yield and its components. Methods: A set of 27 chickpea (Cicer arietinum L.) advanced breeding lines and three check varieties (JAKI 9218, JG 16, RSG 888) were evaluated for phenological and yield performance under three different environments under rainfed cultivation during 2019-20. The data was subjected to ANOVA and GGE Biplot analysis. Result: The first two principal components of the GGE Biplot explained about 80.13% of the total variation in multi-environment trial. The which won where/what biplot indicated that the genotype IPC17-78 performed well at Bhopal and Kanpur location followed by IPC15-12, IPC17-04 and IPC17-35. At Dharwad genotype IPC19-226 performed well followed by IPC19-220, IPC17-53, IPC19-222 and IPC18-63. Based on Mean vs Stability function of GGE Biplot analysis, chickpea genotype IPC17-369 was the most stable and high yielding genotype followed by IPC17-78 and IPC17-53. Genotypes IPC17-35 and IPC17-54 were more stable but had lesser yield potential. In the “Discrimitiveness vs representativeness” biplot, all the environments plotted at far distance from biplot origin indicating that they were all able to discriminate between genotypes; however, Kanpur and Bhopal were the most discriminating locations.
percepção dos atores do sistema de justiça criminal sobre a monitoração eletrônica em Belo Horizonte (MG)
Authors: Souza Rafaelle Lopes
Published: May 2022

A aplicação da monitoração eletrônica, embora recente, tem crescido substancialmente no Brasil. Para defensores de tal mecanismo o seu advento tem o intuito de diminuir a população carcerária, entre presos provisórios e condenados, como também ser uma inciativa mais barata ao estado para controlar e combater do crime do que as tradicionais formas de punição como a prisão. O que se pode afirmar é que a partir da monitoração eletrônica houve uma ampliação do número de pessoas que passaram a ser controlados eletronicamente pelo Estado. Para tanto, o presente artigo tem por objetivo apresentar análise da percepção dos operadores de justiça de Belo Horizonte acerca da Monitoração Eletrônica na capital mineira.
Feeding the world better: crop diversification to build sustainable food systems
Authors: Malézieux Eric , Beillouin Damien , Makowski David
Published: May 2022

Today, major changes are required in global agricultural systems to produce enough healthy food for all, while preserving the quality of land, air and water and safeguarding biodiversity. But producing enough while simultaneously protecting the environment is a particularly complex equation. Agroecology, a key principle of which is the use of agricultural biodiversity, is a promising pathway to achieve these changes. Extensive qualitative and quantitative evidence demonstrates the agricultural and environmental effectiveness of agroecological practices and confirms their capacity to meet the demands of global production in the long term. Among the possible diversification strategies, agroforestry, intercropping and crop rotation can all significantly increase production and enhance biodiversity and ecosystem services (soil quality, pest and disease control, water use and quality). This evidence can serve as a basis for new public policies to be introduced from the local to the global level. The implementation of such policies is crucial in climate-vulnerable regions where demand for food is growing, such sub-Saharan Africa.
Tapu and noa as negotiators of Māori gender roles in pre-colonial Aotearoa and today
Authors:   Te Herenga Waka – Victoria University of Wellington, Wellington, New Zealand, Mitchell Kelly , Olsen-Reeder Vini
Published: May 2022

Tapu and noa are often cited as fundamentals by which we enact tikanga, promote well-being and divide labour. However, exactly how tapu informed precolonial gender divisions of labour is difficult to examine, mostly because of the pervasive influence Christianity has had on cosmological narratives, from which tapu derives (Mikaere, 2017; Rewi, 2010; Te Awekotuku, 1994). This article outlines some commentary on the relationship between tapu, gender roles and colonisation, and tries to extend that scholarship. We posit that the tikanga around tapu and noa in contemporary times may be more rigid than it was before, potentially a negative effect of cosmological colonisation. Furthermore, we suggest that precolonial labour may have been divided by the fundamentals of tapu, whereas in contemporary times it seems gender is the primary consideration. The centring (or recentring) of tapu in such conversations may be a worthy decolonisation avenue as we seek to empower Māori of all genders.
Human milk microbiota: what did we learn in the last 20 years?
Authors: Selma-Royo Marta , Calvo-Lerma Joaquim , Bäuerl Christine , Esteban-Torres Maria , Cabrera-Rubio Raul , Collado Maria Carmen
Published: May 2022

Human milk (HM) is the gold standard for infant nutrition during the first months of life. Beyond its nutritional components, its complex bioactive composition includes microorganisms, their metabolites, and oligosaccharides, which also contribute to gut colonization and immune system maturation. There is growing evidence of the beneficial effects of bacteria present in HM. However, current research presents limited data on the presence and functions of other organisms. The potential biological impacts on maternal and infant health outcomes, the factors contributing to milk microbes’ variations, and the potential functions in the infant’s gut remain unclear. This review provides a global overview of milk microbiota, what the actual knowledge is, and what the gaps and challenges are for the next years.
Aplikasi penggunaan Metode Finite Difference dalam pemodelan air tanah pada kasus pertambangan : literatur review
Authors: Trijayanti Hana , Cahyadi Tedy Agung
Published: May 2022

Pada area kegiatan penambangan terdapat berbagai macam kasus yang berkaitan dengan hidrogeologi. Permasalahan tersebut dapat diselesaikan dengan metode perhitungan numerik, yaitu finite difference. Finite difference digunakan kedalam Visual Modflow dengan membangun suatu model hidrogeologi. Dalam pemodelan Visual Modflow, tahapan yang dilakukan yaitu persiapan model konseptual, menentapkan batas area pemodelan, kalibrasi dan validasi. Pemodelan dapat diaplikasikan untuk menyelesaikan kasus air tanah pada pertambangan yaitu pemodelan air tanah setelah dilakukan penambangan, pemasangan drain hole pada dinding pit, pemodelan air tanah untuk kegiatan dewatering, intrusi air laut akibat adanya penambangan dan pemodelan sebaran kontaminan akibat kolam tailing penambangan. Pemodelan tersebut dapat menjadi acuan dalam monitoring, pengendalian, dan pemanfaatan terkait dengan pengelolaan dan perlindungan air tanah.
Analisis kestabilan lereng low wall Pit UCE di PT Jorong Barutama Grestone
Authors: Purba Pranajaya , Hakim Romla Noor Noor , Mustofa Adip
Published: May 2022

PT Jorong Barutama Greston merupakan salah satu perusahaan pertambangan batubara. Dalam menjalankan kegiatan operasi produksi, perusahaan menghadapi masalah mengenai kestabilan lereng pada area lereng low wall. Ketidakstabilan lereng ini berpotensi menimbulkan longsor yang akan memberikan dampak yang signifikan dalam kegiatan penambangan. Selain menghambat kegiatan produksi, longsor juga dapat sewaktu waktu menimbukan resiko kecelakaan pada pekerja. Kondisi lereng aktual dilapangan menunjukkan ketidakstabilan lereng dimana terbentuknya tension crack dan adanya pergerakan pada area lereng low wall.Kondisi ketidakstabilan pada lereng ini memunculkan asumsi bahwa FK lereng low wall < 1. Maka dilakukan analisis kestabilan lereng menggunakan  perangkat lunak Rocscience Slide v6.0 yang bertujuan untuk mengetahui keselarasan hasil analisis dengan kondisi lereng aktual dilapangan. Metode yang digunakan adalah metode Mogenstern-Prince, dengan bidang kelongsoran diperkirakan adalah busur (circular), ketinggian muka air tanah berdasarkan hasil pengukuran piezometer, dan parameter awal yang digunakan merupakan kuat geser puncak (peak shear strength).  Hasil analisis menunjukkan nilai FK lereng lowwall > 1,7 yang dimana tidak selaras dengan kondisi aktual dilapangan. Maka dilakukan koreksi dengan menggunakan parameter kuat geser yang divariasikan dari nilai kuat geser puncak (peak shear strength) hingga nilai kuat geser sisa (residual shear strength). Hasil koreksi menunjukkan bahwa nilai kuat geser pada lereng low wall merupakan nilai kuat geser sisa (residual shear strength) dengan nilai FK terkecil = 0,943.
Ethical dilemmas of a freshly graduated rural clinician in Kerala, India: a personal reflection
Authors: Mishael J Tom
Published: May 2022

Freshly graduated doctors are the lesser-known workhorses of the rural healthcare system in India. These rural clinicians confront numerous ethical dilemmas in their day-to-day life, which are quite different from the ethical issues they may have encountered during their medical training and internship at a tertiary care hospital. These include taking end of life decisions, breaking bad news, conflicts in the doctor-patient relationship, declaration of death, and counselling of patients or family attendants of terminally ill patients. Yet, the decisions they make during such challenging situations are often influenced by their undergraduate training and limited clinical exposure. This is a personal reflection on the ethical dilemmas that I faced as a young medical graduate, appointed as the resident medical officer of a rural hospital in Kerala, and how they influenced me in my early stages of clinical practice.
Effectiveness of teaching medical ethics to medical students on an online platform: An analysis of students’ perceptions and feedback
Authors: Govindraj Laxmi , Santhosh Samuel , Sunish Serin Cheruvathoor , Gopalakrishnan Abinaya Vannapatti , Chandy Sujith J , Oommen Vinay , Shanthi FX Margaret
Published: May 2022

Medical ethics education along with attitude and communication training has been incorporated into the regular MBBS curriculum in India from 2019, so as to encourage a caring and communicative approach by doctors towards patients. It would be important to understand the relevance of the educational module in the form of cases to ensure an optimal learning process for future students and doctors in the making. We selected three cases and conducted online debates among small groups of second year MBBS students. Students submitted narratives and their reflections after discussing each case and gave overall feedback. Our findings suggested that the students recognised the complexity of taking decisions when presented with ethical dilemmas and appreciated the opportunity to voice opposing views. The online platform was effective and may be considered in the future as a medium to help integrate discussions on medical ethics alongside clinical work.
Perceptions of staff and students about the NC(V) model of workplace Engineering artisan training offered by South African TVET colleges
Authors: Du Plooy B. , du Preez K.
Published: May 2022

Vocational training is a contentious issue in South Africa, where large per centages are regularly cited for unemployment statistics, and in particular for youth and post-school unemployment. Vocational study programmes at Technical and Vocational Education and Training (TVET) colleges are often seen as one possible remedy to these problems. The Department of Higher Education and Training’s (DHET) long-term objective is to increase the number of learners that will qualify as artisans, which represent a major scarce/critical skills area in South Africa. However, the throughput and certification rates of TVET students are disconcertingly low, with National Certificate (Vocational) (NC(V)) Engineering courses regularly cited as having some of the lowest rates. This article reports on a small research study on the perceptions of TVET staff and students about NC(V) Engineering programmes, conducted at two TVET colleges in South Africa. Qualitative and quantitative methods were used to collect data from NC(V) Engineering students and lecturers. The most important findings of the study include that there is a critical collaboration gap between industry and the TVET sector and that both NC(V) staff and students experience the need for addressing the (im)balance of time spent on practical versus theoretical training as part of NC(V) programmes. A clear understanding of the perceptions and concerns of TVET NC(V) Engineering lecturers and students may assist in addressing issues locally, at individual TVET colleges, and globally, at national policy and Sector Education and Training Authority (SETA) level, that could in future serve to contribute to improved academic performance, including higher throughput and certification rates, of NC(V) Engineering students.
Self-regulated learning strategies and academic performance of accounting students at a South African university
Authors: Papageorgiou E.
Published: May 2022

Orientation: Knowledge of a subject and cognitive strategies are usually not enough to increase students’ academic performance; students need also to be motivated to use learning strategies and deal with test and examination anxiety to be successful, especially in their first year of study. Purpose: The purpose of the study was to measure first-year accounting students’ motivational aspects and learning strategies versus academic performance at a South African university. Research questions: Three research questions were used to determine if students were motivated and applied learning strategies to perform in the accounting course: 1) What motivational variables and learning strategies are related to academic performance measuring students’ final Accounting marks, controlling for admission requirements, gender, race, and degree choice? 2) Are prior knowledge demographic and degree choice related to motivational variables and learning strategies? 3) Are motivational variables related to learning strategy variables for Accounting students regarding their Degree choice? Method: A full scale “Motivated Strategies for Learning Questionnaire” (MSLQ) was used to assess accounting students’ (N=617) motivational orientations and their use of different learning strategies for an accounting course. Multiple regression analysis was applied to explore the relationship among the different variables. Findings: The findings of this study are relevant to learning in predicting academic performance of first-year accounting students and relationships between self-regulated learning and students’ degree choice, gender, race, academic performance and admission requirements. Limitation and further recommendation: This study was only deployed to accounting students at one South African university. A further recommendation would be to collaborate with other disciplines and universities to determine if motivational and learning strategies differ from those of accounting students at a South African university. Value of the study and practical implications: The value of the study provides insights and evidence on motivational beliefs and learning strategies of students in accounting studies and how students can improve their academic performance.
The pedagogy of hyperlinkages: Knowledge curatorialism and the archive of kindness
Authors: Auerbach J.
Published: May 2022

This article uses a student assessment developed in the “emergency” conditions of the Covid-19 pandemic in South Africa as a tool for refracting and reflecting (Strassler 2011) the changing realities of higher education around the world. It examines the Archive of Kindness as an example of the possibilities enabled by digitally mediated learning, as well as the challenges of teaching and learning in environments where students enter university with varying degrees of digital literacy and skill. It poses questions pertaining to the futures of higher education in a world in which biopolitics are increasingly determined by and through screens, and suggests that uncritical engagements with digital platforms and the corporate entities behind them pose dangers to emerging forms of citizenship. The article details the processes of knowledge curatorialism which are increasingly likely to determine the shape of learning in tertiary education, particularly within the university sector. Here, it argues that the Humanities and Social Sciences will need to play a leading role in providing the language and tools for thinking through the pedagogy of hyperlinkages, where the boundaries between online and offline spaces are increasingly difficult to parse.
Fen Bilimleri Öğretmen Adaylarının 21. Yüzyıl Öğrenen Becerileri ile Öğrenme Biçimleri, Öğrenme Stilleri ve Çoklu Zekâ Alanları Arasındaki İlişkilerin İncelenmesi
Authors: İPEKŞEN Seren , ZORLU Yusuf
Published: May 2022

Çalışmada fen bilimleri öğretmen adaylarının 21. yüzyıl öğrenen becerileri ile çoklu zeka alanları, öğrenme biçim ve stilleri arasındaki ilişkilerinin belirlenmesi amaçlanmaktadır. Araştırmanın yöntemi nicel araştırma yöntemlerinden ilişkisel araştırma yöntemidir. Üç devlet üniversitesinin eğitim fakültelerinin fen bilgisi öğretmenliği bölümünün üçüncü ve dördüncü sınıflarında öğrenim gören 318 fen bilimleri öğretmen adayı çalışmanın örneklemini oluşturmaktadır. Araştırmada “21. Yüzyıl Öğrenen Becerileri Ölçeği”, “Kolb Öğrenme Stilleri Envanteri” ve “Çoklu Zeka Envanteri” veri toplama araçları olarak kullanılmıştır. Araştırmadan elde edilen verilere analizleri için basit korelasyon, basit doğrusal regresyon ve tek yönlü varyans analizi (ANOVA) yapılmıştır. Araştırmadan elde edilen bulgulara göre fen bilimleri öğretmen adaylarının öğrenme biçimleri ve çoklu zeka alanlarının, 21. yüzyıl öğrenen becerilerinin birer yordayıcısı olduğu tespit edilmiştir. Ayrıca fen bilimleri öğretmen adaylarının öğrenme stillerine göre 21. yüzyıl öğrenen becerileri arasında fark bulunmamıştır. Araştırmada ulaşılan sonuçlara göre çoklu zeka alanlarına yönelik ilgilerine ve öğrenme biçimlerine göre farklı öğrenme model/yöntem/teknikleri bir araya getirilip uygulanarak fen bilimleri öğretmen adaylarına 21. yüzyıl becerileri kazandırabilir.
Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse
Authors: Schade Mathew , Sanabria Jacqueline A , Mallick Amrita , Aguilar Rodrigo , Andryka Michael , Schlatzer Daniela , Li Xiaolin , Hazlett F E , Kachman Maureen , Raskind Aravinda , Udoh Utibe-Abasi , Rajan Pradeep K , Sanabria Juan D , Brunengraber Henri , Sodhi Komal , Pierre Sandrine , Xie Zijian , Shapiro Joseph I , SANABRIA JUAN
Published: May 2022

BACKGROUND. Two sequelae of non-alcoholic steatohepatitis (NASH), ESLD and HCC, have become the leading causes for liver transplantation in the Western. The present study aims to approach the cellular metabolic disturbances involved in NASH progression that are associated with microbiota community changes. METHODS. Metabolic effects and microbiota community changes were explored in the murine with NASH progression by blocking the Na/K-ATPase/Src/reactive oxygen amplification loop using the synthetic targeting peptide pNaKtide. DNA from the terminal ileum microbiota habitat was obtained and amplified by PCR to develop DNA bacterial phylogenic sequence analysis of wild type and treated animals at 12, 24 and 48 weeks. Induced changes by pSrc normalization at 24 weeks were correlated with liver morphological changes, intestinal CD4+/CD8+ ratio, and liver macrophage CD14+ expression. Differences among groups were evaluated by ANOVA/t-test and Principal Component Analysis (PCA). RESULTS. Microbiota communities varied significantly at all time points (12, 24 and 48 weeks), with an increase of Verrucomicrobia and a decrease of Bacteroidetes and Firmicutes in the HFD group. Microbiota community changes regressed to their wild-type state at 24 weeks on treated animals, and those changes were associated with a decrease in liver inflammation and senescence, lower ileum CD4+/CD8+ T cells and higher liver CD14+ cells (p<0.05). Concomitantly, the metabolic disturbances in our diet-induced NASH model were normalized by NKA/Src signaling blockage and exercise with a paucity of apoptotic activity, mitigation of cell senescence, and regression of liver fibrosis (p<0.01). CONCLUSIONS. pSrc inhibition at caveolar α1-Na/K-ATPase rescinded NASH-related metabolic disturbances establishing resident physiological microbiota communities with concomitant paucity on apoptotic activity and regression of liver fibrosis; effects that were associated with both gut and liver T-lymphocyte responses.
Performance Evaluation Analysis of Spark Streaming Backpressure for Data-Intensive Pipelines
Authors: Matteussi Kassiano Jose , Julio Dos Anjos , Leithardt Valderi , Fernando Resing Geyer Claudio
Published: May 2022

In the past decades, a significant rise in the adoption of streaming applications has changed the decision-making process for the industry and academia sectors. This movement led to the emergence of a plurality of Big Data technologies such as Apache Storm, Spark, Heron, Samza, Flink, and other systems to provide in-memory processing for real-time Big Data analysis at high throughput. Spark Streaming represents one of the most popular open-source implementations which handles an ever-increasing data ingestion and processing by using the Unified Memory Manager to manage memory occupancy between storage and processing regions dynamically, which is the focus of this study. The problem behind memory management for data-intensive stream processing pipelines is that the incoming data is faster than the downstream operators can consume. Consequently, the backpressure of Spark acts in the opposite direction of downstream operators. In such a case, the incoming data overwhelms the memory manager and provokes memory leak issues. As a result, it affects the performance of applications generating, e.g., high latency, low throughput, or even data loss. In such a case, the initial intuition motivating our work is that memory management became the critical factor in keeping processing at scale and system stability of Spark. This work provides a deep dive into Spark backpressure, evaluates its structure, presents the main characteristics to support data-intensive streaming pipelines, and investigates the current in-memory-based performance issues.
A Model for the Proliferation-Quiescence Transition in Human Cells
Authors: Mapfumo Kudzanayi Z. , Pagan’a Jane C. , Juma Victor Ogasa , Kavallaris Nikos I. , Madzvamuse Anotida
Published: May 2022

The process of revitalising quiescent cells in order for them to proliferate plays a pivotal role in the repair of warn out tissues as well as for tissue homeostasis. This process is also crucial in the growth, development and well-being of higher multi-cellular organisms such as mammals. Deregulation of quiescent-proliferation transition is related to many diseases, in particular cancer. Recent studies have revealed that this process is regulated tightly by the Rb−E2F bistable switch mechanism. Based on experimental observations, in this study, we formulate a mathematical model to examine the effect of the growth factor concentration on the proliferation-quiescence transition in human cells. Working with a non-dimensionalised model, we prove positivity, boundedness and uniqueness of solutions. To understand model solution behaviour close to bifurcation points, we carry out bifurcation analysis, which is further verified by use of numerical bifurcation analysis, sensitivity analysis and numerical simulations. Indeed, bifurcation and numerical analysis of the model predicted a transition between stable, bistable and stable states, which are dependent on the growth factor concentration parameter (GF). The derived predictions confirm experimental observations.
LncRNA Prostate Androgen-Regulated Transcript 1 (Part-1) Promotes the Non-small-Cell Lung Cancer Progression via Regulating miR-204-3p/IGFBP-2 pathway
Authors: Li Kenfen , Zhang Yanping , Wang Yunfeng , Guo Xin , Dai Xianhui , Song Li
Published: May 2022

Lung cancer is a common malignant tumor of the lung and the leading cause of cancer mortality worldwide. Non-small-cell lung cancer (NSCLC) accounts for 80%–85% of lung cancer, 40% of NSCLCs will have spread beyond the lungs by the time it is diagnosed. Long non-coding RNA (LncRNA) prostate androgen-regulated transcript 1 (PART-1) was reported that promote the development of several cancers. In the current study, we conducted experiments to investigate the role of PART-1 in the proliferation, invasion, and migration of NSCLC. The expression level of the PART-1 gene increased significantly in the NSCLC cell lines, including A549, H1229, H1650, H1975, and PC9. Knocking down of PART-1 inhibited the proliferation, invasion, and migration of A549 cells, moreover, decreased the tumor proliferation in nude mice. We confirmed that PART-1 targeted miR-204-3p directly, and miR-204-3p targeted the insulin-like growth factor binding protein 2 (IGFBP-2) directly. Furthermore, we discovered that PART-1 involved the NSCLC progression by regulating the miR-204-3p-targeted IGFBP-2 pathway. LncRNA PART-1 might be a target for treating NSCLC, and a warning sign of diagnosis of early lung cancer.
Hogyan zajlott a magyar nyelv digitális tanítása a járványhelyzet alatt?
Authors: Jánk István , Lőrincz Marina
Published: May 2022

A koronavírus miatt kialakult járványhelyzet alapvető változásokat hozott az élet számos területén, így az oktatásban is. Ezt több szakember több szempontból is vizsgálta, ám az anyanyelvi nevelésről, a magyar nyelv tanításáról mind ez idáig nem esett szó ebben a vonatkozásban. A tanulmány ezt a hiányt kívánja betölteni egy, 234 magyar nyelvet tanító pedagógus bevonásával készült vizsgálat eredményeinek az ismertetésével, így adva a digitális tanrend szűkebb keresztmetszetéről lenyomatot. A 2020 második felében zajlott kérdőíves felmérés többek között az online anyanyelvi oktatás hatékonyságára, eszközeire és általánosságban a pedagógusok tapasztalataira fókuszált. A vizsgálat abból az előzetes feltevésből indult ki, hogy bár a pedagógusoknak kevés idejük volt felkészülni az online oktatásra, meg tudtak birkózni a feladattal. Természetesen ez nem mehetett zökkenőmentesen, és a túlságosan gyors átállásnak megvolt a maga ára és korlátja mind az eszközök, mind a módszertani kérdések területén.
Unravelling the Mystery of Inhibitor Resistant Calcite Impacting Onshore and Offshore Operations
Authors: Bourne Hugh Malcolm , Abbasov Adil Almuk , Smith Ben Edward
Published: May 2022

Magnesian calcite has been identified as the main constituent of solids fouling several bp facilities in the North Sea and Azerbaijan and in partner operations in other locations. These solids were, for many years, thought to be calcite scale for a number of reasons. The deposits formed compacted solids and thus looked similar to scale, they effervesced and dissolved in acid and calcium was detected as the main constituent. XRD analysis, however, revealed the deposits were magnesian calcite. The inclusion of magnesium into the crystal cannot be co-precipitated with calcite scale under typical oilfield conditions and timelines and their deposition cannot be controlled by conventional scale inhibitor injection. These solids, transported from the reservoir with the produced fluids can act as scavenger sites, reducing the effective concentration of scale inhibitors available to manage conventional scale deposition. The fact that these solids, in many ways, present themselves as a conventional scale has perhaps hidden the extent of their occurrence in offshore and onshore operations. Magnesian calcite has been identified as the main constituent of retrieved solids that were (1) adhered to tubing and restricting production in a North Sea field (2) impacting operation of subsurface safety valves in both North Sea and Caspian Sea operations (3) reducing the efficiency of heaters and coolers offshore North Sea and onshore in the Caspian and (4) plugging strainers in the produced water handling systems offshore North Sea and onshore Caspian.

This paper will describe how this ‘pseudo scale’ was detected and its prevalence, using field case examples from several bp operated and non-operated assets. It describes the theories developed to rationalise magnesian calcite deposition onto production surfaces including the possible role of ‘sticky’ molecules and the technology bp is evaluating to holistically manage this fouling phenomena. It will share dispersant chemical field trial performance data and the deployment of electromagnetic fields to determine the impact of changing zeta potential on the attraction of fine magnesian calcite particles to the surface and thus the fouling rate.