bluuebunny/crossref_metadata_2025 huggingface dataset:
The Puzzling Falcomurus Mandal (Collembola, Orchesellidae, Heteromurinae): A Review
Authors: Bellini Bruno C. , Souza Paolla G. C. de , Greenslade Penelope
Published: July 2021

Falcomurus Mandal is currently a monotypic genus of Heteromurinae described from India in 2018. Its key characters are the first antennal segment subdivided, the second undivided and the third annulated; the first abdominal segment lacking macrochaetae; and the presence of a sinuous modified macrochaeta on the proximal dens. Some details of its morphology were recently put in doubt, and so its genus status and affinities remain uncertain. Here, we revise the genus based on the type material of Dicranocentrus litoreus Mari-Mutt, as well as provide the description of two new species from Australian archipelagos and a reinterpretation of the chaetotaxy of Falcomurus chilikaensis Mandal and D. halophilus Mari-Mutt. After our revision, Falcomurus shows a well-conserved chaetotaxy and overall morphology, which allowed us to provide an updated generic diagnosis. While the antennae morphology of Falcomurus resembles that of Dicranocentrus Schött, its dorsal sensillar and macrochaetotaxy suggest it is closely related to Heteromurus Wankel, as originally stated by Mandal. The main features useful to separate Falcomurus species are the head, mesothorax and fourth abdominal segment chaetotaxy. We also provide a key to its five species, a comparative table and notes on the affinities and distribution of Falcomurus.
Functional Roles of Homologous Recombination and Non-Homologous End Joining in DNA Damage Response and Microevolution in Cryptococcus neoformans
Authors: Jung Kwang-Woo , Jung Jong-Hyun , Park Ha-Young
Published: July 2021

DNA double-strand breaks (DSBs) are the most deleterious type of DNA lesions because they cause loss of genetic information if not properly repaired. In eukaryotes, homologous recombination (HR) and non-homologous end joining (NHEJ) are required for DSB repair. However, the relationship of HR and NHEJ in DNA damage stress is unknown in the radiation-resistant fungus Cryptococcus neoformans. In this study, we found that the expression levels of HR- and NHEJ-related genes were highly induced in a Rad53–Bdr1 pathway-dependent manner under genotoxic stress. Deletion of RAD51, which is one of the main components in the HR, resulted in growth under diverse types of DNA damage stress, whereas perturbations of KU70 and KU80, which belong to the NHEJ system, did not affect the genotoxic stresses except when bleomycin was used for treatment. Furthermore, deletion of both RAD51 and KU70/80 renders cells susceptible to oxidative stress. Notably, we found that deletion of RAD51 induced a hypermutator phenotype in the fluctuation assay. In contrast to the fluctuation assay, perturbation of KU70 or KU80 induced rapid microevolution similar to that induced by the deletion of RAD51. Collectively, Rad51-mediated HR and Ku70/Ku80-mediated NHEJ regulate the DNA damage response and maintain genome stability.
Sustaining Cultural Genocide—A Look at Indigenous Children in Non-Indigenous Placement and the Place of Judicial Decision Making—A Canadian Example
Authors: Choate Peter , Bear Chief Roy , Lindstrom Desi , CrazyBull Brandy
Published: July 2021

The Truth and Reconciliation Commission has called upon Canada to engage in a process of reconciliation with the Indigenous peoples of Canada. Child Welfare is a specific focus of their Calls to Action. In this article, we look at the methods in which discontinuing colonization means challenging legal precedents as well as the types of evidence presented. A prime example is the ongoing deference to the Supreme Court of Canada decision in Racine v Woods which imposes Euro-centric understandings of attachment theory, which is further entrenched through the neurobiological view of raising children. There are competing forces observed in the Ontario decision on the Sixties Scoop, Brown v Canada, which has detailed the harm inflicted when colonial focused assimilation is at the heart of child welfare practice. The carillon of change is also heard in a series of decisions from the Canadian Human Rights Tribunal in response to complaints from the First Nations Child and Family Caring Society of Canada and the Assembly of First Nations regarding systemic bias in child welfare services for First Nations children living on reserves. Canadian federal legislation Bill C-92, “An Act respecting First Nations, Inuit and Métis children, youth and families”, brings in other possible avenues of change. We offer thoughts on manners decolonization might be approached while emphasizing that there is no pan-Indigenous solution. This article has implications for other former colonial countries and their child protection systems.
Mechanical and Durability Properties of Latex-Modified Hybrid Fiber-Reinforced Roller-Compacted Rapid-Set Cement Concrete for Pavement Repair
Authors: Lee Su-Jin , Shin Hyung-Jin , Park Chan-Gi
Published: July 2021

This study evaluated the mechanical properties and durability performance of latex-modified hybrid fiber-reinforced roller-compacted rapid-set cement concrete (LMHFRCRSC) for emergency repair of concrete pavement. Experimental parameters included the blend ratio of the hybrid fiber, which comprised natural jute fiber (0–0.2 vol.%) and structural synthetic fiber (0–2 vol.%). The mechanical performance of LMHFRCRSC of various blend ratios was evaluated in terms of compressive, flexural, and splitting tensile strength. Durability assessment included chlorine ion penetration and abrasion resistance measurements. Compressive and flexural strength values of 21 and 3.5 MPa, respectively, were the set targets after 4 h of curing; a compressive strength of 35 MPa, a flexural strength of 4.5 MPa, a splitting tensile strength of 4.2 MPa, and chloride ion penetration of 2000 C or less were required after 28 days of curing. Our test results confirmed that all mix proportions satisfied the target values, regardless of the blend ratio of the hybrid fiber. Specifically, the mechanical performance of the concrete improved as the blend ratio of the structural synthetic fiber increased. With regard to durability, a greater amount of jute fiber, a hydrophilic fiber, enhanced the concrete’s durability. Additionally, incorporating jute fiber of 0.6 kg/m3 provided excellent chlorine ion penetration resistance. The optimal blend ratio for the hybrid fiber was natural jute fiber at 0.6 kg/m3 and structural synthetic fiber at 13.65 kg/m3 (mix: J0.6 + P13.65); with this mix proportion, a chloride ion penetration amount of 1000 C or less and maximum mechanical performance were achieved.
Increasing Trend of Nontuberculous Mycobacteria Isolation in a Referral Clinical Laboratory in South Korea
Authors: Lee Yu-Mi , Kim Min-Jin , Kim Young-Jin
Published: July 2021

Background and Objectives: Nontuberculous mycobacteria (NTM) infections are increasing worldwide. We evaluated the annual trends of NTM isolation on acid-fast bacillus (AFB) culture, compared to that of Mycobacterium tuberculosis, and the distribution of NTM species nationwide in South Korea. Materials and Methods: The study was conducted in a diagnostic center that is a major referral laboratory for the diagnosis of tuberculosis and NTM in South Korea. All laboratory results of AFB culture from January 2014 to December 2019 were collected. All NTM identified were definitively identified to the species level. Results: A total of 345,871 tests were performed for the diagnosis of mycobacteria. The isolation rate of NTM and M. tuberculosis was 3.7% (12,969 cases) and 4.4% (15,081 cases), respectively. The annual isolation rate of NTM increased gradually from 2.7% in 2014 to 4.8% in 2019, whereas that of M. tuberculosis decreased from 6.2% to 3.3%. There were 4988 cases of NTM identified to the species level. M. avium complex (MAC) was the most common species isolated from pulmonary sites (59.8%), followed by M. gordonae (9.2%), M. abscessus (7.0%), and M. fortuitum (5.5%). Extrapulmonary NTM were identified in 29 cases (0.6%). MAC was also the most common NTM species isolated from extrapulmonary sites (65.5%), followed by M. kansasii (10.3%), M. abscessus (6.9%), and M. fortuitum (6.9%). Conclusions: The annual isolation rate of NTM has increased gradually, whereas that of M. tuberculosis has decreased. Follow-up studies of the increases in NTM identification and NTM infections in South Korea are needed.
Clinical Usefulness of Ultrasound-Guided Fine Needle Aspiration and Core Needle Biopsy for Patients with Axillary Lymphadenopathy
Authors: Fujioka Tomoyuki , Mori Mio , Kubota Kazunori , Yamaga Emi , Yashima Yuka , Oda Goshi , Nakagawa Tsuyoshi , Onishi Iichiroh , Ishiba Toshiyuki , Tateishi Ukihide
Published: July 2021

Background and Objectives: It is necessary to properly diagnose and manage axillary lymphadenopathy caused by a variety of diseases. This study aimed to evaluate the utility of ultrasound (US)-guided sampling in patients with axillary lymphadenopathy. Materials and Methods: Patients with axillary lymphadenopathy (excluding patients with newly diagnosed breast cancer) who underwent US-guided fine needle aspiration (FNA) or core needle biopsy (CNB) at a single center between February 2016 and September 2020 were retrospectively examined. The association between US imaging findings and malignancy was investigated and the diagnostic performance of US-guided sampling was assessed. Results: Fifty-five patients (including eight males) were included in the study; of these, 34 patients (61.8%) were finally diagnosed with a malignant lymph node lesion. Twenty-two patients (40.0%) had undergone FNA and 33 (60.0%) had undergone CNB. Larger short and long axis diameters, thicker lymph node cortex, and the absence of fatty hilum on the US were significantly associated with malignancy (p < 0.05). The diagnostic performance of FNA, CNB, and FNA + CNB was excellent (sensitivity, specificity, and accuracy of 0.909, 0.900, and 0.917 for FNA, 0.958, 1.000, and 0.970 for CNB, and 0.941, 0.952, and 0.945 for FNA + CNB, respectively). Conclusions: US-guided FNA and CNB play an important role in the diagnosis and management of patients with axillary lymphadenopathy.
Extracorporeal Support Prognostication—Time to Move the Goal Posts?
Authors: Shah Neel , Said Ahmed S.
Published: July 2021

Advances in extracorporeal membrane oxygenation (ECMO) technology are associated with expanded indications, increased utilization and improved outcome. There is growing interest in developing ECMO prognostication scores to aid in bedside decision making. To date, the majority of available scores have been limited to mostly registry-based data and with mortality as the main outcome of interest. There continues to be a gap in clinically applicable decision support tools to aid in the timing of ECMO cannulation to improve patients’ long-term outcomes. We present a brief review of the commonly available adult and pediatric ECMO prognostication tools, their limitations, and future directions.
First-Principles Density Functional Theory Calculations of Bilayer Membranes Heterostructures of Ti3C2T2 (MXene)/Graphene and AgNPs
Authors: Berdiyorov Golibjon. R. , Madjet Mohamed E. , Mahmoud Khaled. A.
Published: July 2021

The properties of two-dimensional (2D) layered membrane systems can be medullated by the stacking arrangement and the heterostructure composition of the membrane. This largely affects the performance and stability of such membranes. Here, we have used first-principle density functional theory calculations to conduct a comparative study of two heterostructural bilayer systems of the 2D-MXene (Ti3C2T2, T = F, O, and OH) sheets with graphene and silver nanoparticles (AgNPs). For all considered surface terminations, the binding energy of the MXene/graphene and MXene/AgNPs bilayers increases as compared with graphene/graphene and MXene/MXene bilayer structures. Such strong interlayer interactions are due to profound variations of electrostatic potential across the layers. Larger interlayer binding energies in MXene/graphene systems were obtained even in the presence of water molecules, indicating enhanced stability of such a hybrid system against delamination. We also studied the structural properties of Ti3C2X2 MXene (X = F, O and OH) decorated with silver nanoclusters Agn (n ≤ 6). We found that regardless of surface functionalization, Ag nanoclusters were strongly adsorbed on the surface of MXene. In addition, Ag nanoparticles enhanced the binding energy between MXene layers. These findings can be useful in enhancing the structural properties of MXene membranes for water purification applications.
High-Temperature Behavior of Metals
Authors: Gariboldi Elisabetta , Spigarelli Stefano
Published: July 2021

The design of new alloys as well as the optimization of processes involving whichever form of high-temperature deformation cannot disregard the characterization and/or modelling of the high-temperature structural response of the material [...]
Influence of Cutting Speed in Turning and Force in Subsequent Diamond Smoothing on Magnetic Properties of Steel 100Cr6
Authors: Maurer Oliver , Liborius Hendrik , Rauch Christiane , Bähre Dirk , Schubert Andreas
Published: July 2021

Magnetic properties are known to be crucial in the application of electrical steel and they are therefore covered by manifold studies. Other ferromagnetic materials are out of scope in this respect, even if the importance of magnetism of conventional steel is evident. Additionally, there is a contradiction regarding the major influence on magnetic properties. Machining, transport, and storage are possible influencing variables. In the experimental investigations, specimens consisting of the bearing steel 100Cr6 are machined by turning and partly by subsequent diamond smoothing. While machining using several cutting speeds and smoothing forces, the thermoelectrical voltage, current, and the components of the resultant force are recorded. The results show how the near-surface plastic deformations evolve throughout the machining process. Additionally, it was found that the magnetic properties and other properties of the surface layer are influenced in different ways depending on turning and diamond smoothing parameters. Correlations between in situ and ex situ measured values are shown. This study aims to solve the aforementioned question by quantification of machining impacts of cutting speed in turning and force in diamond smoothing and its dependence on transport and storage.
Differential Responses of Methionine Sulfoxide Reductases A and B to Anoxia and Oxidative Stress in the Freshwater Turtle Trachemys scripta
Authors: Reiterer Melissa , Bruce Lynsey , Milton Sarah
Published: July 2021

Oxidative stress has been acknowledged as a major factor in aging, senescence and neurodegenerative conditions. Mammalian models are susceptible to these stresses following the restoration of oxygen after anoxia; however, some organisms including the freshwater turtle Trachemys scripta can withstand repeated anoxia and reoxygenation without apparent pathology. T. scripta thus provides us with an alternate vertebrate model to investigate physiological mechanisms of neuroprotection. The objective of this study was to investigate the antioxidant methionine sulfoxide reductase system (Msr) in turtle neuronal tissue. We examined brain transcript and protein levels of MsrA and MsrB and examined the potential for the transcription factor FOXO3a to regulate the oxygen-responsive changes in Msr in vitro. We found that Msr mRNA and protein levels are differentially upregulated during anoxia and reoxygenation, and when cells were exposed to chemical oxidative stress. However, while MsrA and MsrB3 levels increased when cell cultures were exposed to chemical oxidative stress, this induction was not enhanced by treatment with epigallocatechin gallate (EGCG), which has previously been shown to enhance FOXO3a levels in the turtle. These results suggest that FOXO3a and Msr protect the cells from oxidative stress through different molecular pathways, and that both the Msr pathway and EGCG may be therapeutic targets to treat diseases related to oxidative damage.
Metabolomics-Based Evaluation of Crop Quality Changes as a Consequence of Climate Change
Authors: Romero Helena , Pott Delphine M. , Vallarino José G. , Osorio Sonia
Published: July 2021

Fruit composition determines the fruit quality and, consequently, consumer acceptance. As fruit quality can be modified by environmental conditions, it will be impacted by future alterations produced by global warming. Therefore, agricultural activities will be influenced by the changes in climatological conditions in cultivable areas, which could have a high socioeconomic impact if fruit production and quality decline. Currently, different stresses are being applied to several cultivated species to evaluate their impact on fruit metabolism and plant performance. With the use of metabolomic tools, these changes can be precisely measured, allowing us to determine changes in the patterns of individual compounds. As these changes depend on both the stress severity and the specific species involved and even on the specific cultivar, individual analysis must be conducted. To date, the most-studied crops have mainly been crops that are widely cultivated and have a high socioeconomic impact. In the near future, with the development of these metabolomic strategies, their implementation will be extended to other species, which will allow the adaptation of cultivation conditions and the development of varieties with high adaptability to climatological changes.
In Situ Construction of ZnO/Ni2S3 Composite on Ni Foam by Combing Potentiostatic Deposition with Cyclic Voltammetric Electrodeposition
Authors: Lv Sa , Geng Peiyu , Wang Huan , Yang Fan , Yang Jia , Wang Chao , Chi Yaodan , Yang Xiaotian
Published: July 2021

The ZnO/Ni2S3 composite has been designed and in situ synthesized on Ni foam substrate by two steps of electrodeposition. ZnO was achieved on Ni foam by a traditional potentiostatic deposition, followed by cyclic voltammetric (CV) electrodeposition, to generate Ni2S3, where the introduction of ZnO provides abundant active sites for the subsequent Ni2S3 electrodeposition. The amount of deposit during CV electrodeposition can be adjusted by setting the number of sweep segment and scan rate, and the electrochemical characteristics of the products can be readily optimized. The synergistic effect between the ZnO as backbones and the deposited Ni2S3 as the shell enhances the electrochemical properties of the sample significantly, including a highly specific capacitance of 2.19 F cm−2 at 2 mA cm−2, good coulombic efficiency of 98%, and long-term cyclic stability at 82.35% (4000 cycles).
Thermally Assisted Grinding of Cassiterite Associated with Pollimetallic Ore: A Comparison between Microwave and Conventional Furnaces
Authors: He Chunlin , Zhao Jian , Su Xiujuan , Ma Shaojian , Fujita Toyohisa , Wei Yuezhou , Yang Jinlin , Wei Zongwu
Published: July 2021

We investigated the influence of microwave and conventional heating pretreatments on the grinding of cassiterite associated with pollimetallic ore. The minerals that exhibited a stronger microwave absorption ability crushed first, which is the main difference between the microwave and the traditional heating pretreatments. The distribution of Fe, Pb, Zn, and Sn increased in the fine size range (−0.425 mm). The Fe and Pb grades in the size ranges of −3.2 + 2 mm and −2 + 1 mm after the microwave pretreatment (6 kW, 1 min) were lower than those of the traditional heating (12 kW, 400 °C, 20 min), indicating that the microwave selective heating was beneficial for pyrite and jamesonite. The grade and distribution of Sn decreased significantly in the size ranges of −3.2 + 2 mm and −2 + 1 mm and increased in the size ranges of −0.425 + 0.15 mm and −0.15 + 0.074 mm. Microwave heating treatment promoted the grinding of sulfide ore and reduced the cassiterite overgrinding.
Semi-Synthesis and In Vitro Anti-Cancer Evaluation of Magnolol Derivatives
Authors: Sun Xiao-Long , Zhu Mei-Lin , Dai Yi-Qun , Li Hong-Mei , Li Bo-Han , Ma Hui , Zhang Chang-Hao , Wu Cheng-Zhu
Published: July 2021

Magnolol (MAG), a biphenolic neolignan, has various biological activities including antitumor effects. In this study, 15 MAG derivatives were semi-synthesized and evaluated for their in vitro anticancer activities. From these derivatives, compound 6a exhibited the best cytotoxic activity against four human cancer cell lines, with IC50 values ranging from 20.43 to 28.27 μM. Wound-healing and transwell assays showed that compound 6a significantly inhibited the migration and invasion of MDA-MB-231 cells. In addition, Western blotting experiments, performed using various concentrations of 6a, demonstrated that it downregulates the expression of HIF-1α, MMP-2, and MMP-9 in a concentration-dependent manner. Overall, these results suggest that substituting a benzyl group having F atoms substituted at the C2 position on MAG is a viable strategy for the structural optimization of MAG derivatives as anticancer agents.
Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation
Authors: Zveaghintseva Marina , Stingaci Eugenia , Pogrebnoi Serghei , Smetanscaia Anastasia , Valica Vladimir , Uncu Livia , Ch. Kravtsov Victor , Melnic Elena , Petrou Anthi , Glamočlija Jasmina , Soković Marina , Carazo Alejandro , Mladěnka Přemysl , Poroikov Vladimir , Geronikaki Athina , Macaev Fliur Z.
Published: July 2021

Herein we report the synthesis of some new 1H-1,2,4-triazole functionalized chromenols (3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1H-1,2,4-triazole-1-yl) with salicylic aldehydes and the evaluation of their antifungal activity. In silico prediction of biological activity with computer program PASS indicate that the compounds have a high novelty compared to the known antifungal agents. We did not find any close analog among the over 580,000 pharmaceutical agents in the Cortellis Drug Discovery Intelligence database at the similarity cutoff of 70%. The evaluation of antifungal activity in vitro revealed that the highest activity was exhibited by compound 3k, followed by 3n. Their MIC values for different fungi were 22.1–184.2 and 71.3–199.8 µM, respectively. Twelve from fourteen tested compounds were more active than the reference drugs ketoconazole and bifonazole. The most sensitive fungus appeared to be Trichoderma viride, while Aspergillus fumigatus was the most resistant one. It was found that the presence of the 2-(tert-butyl)-2H-chromen-2-ol substituent on the 4th position of the triazole ring is very beneficial for antifungal activity. Molecular docking studies on C. albicans sterol 14α-demethylase (CYP51) and DNA topoisomerase IV were used to predict the mechanism of antifungal activities. According to the docking results, the inhibition of CYP51 is a putative mechanism of antifungal activity of the novel chromenol derivatives. We also showed that most active compounds have a low cytotoxicity, which allows us to consider them promising antifungal agents for the subsequent testing activity in in vivo assays.
Glycosylation States on Intact Proteins Determined by NMR Spectroscopy
Authors: Hargett Audra A. , Marcella Aaron M. , Yu Huifeng , Li Chao , Orwenyo Jared , Battistel Marcos D. , Wang Lai-Xi , Freedberg Darón I.
Published: July 2021

Protein glycosylation is important in many organisms for proper protein folding, signaling, cell adhesion, protein-protein interactions, and immune responses. Thus, effectively determining the extent of glycosylation in glycoprotein therapeutics is crucial. Up to now, characterizing protein glycosylation has been carried out mostly by liquid chromatography mass spectrometry (LC-MS), which requires careful sample processing, e.g., glycan removal or protein digestion and glycopeptide enrichment. Herein, we introduce an NMR-based method to better characterize intact glycoproteins in natural abundance. This non-destructive method relies on exploiting differences in nuclear relaxation to suppress the NMR signals of the protein while maintaining glycan signals. Using RNase B Man5 and RNase B Man9, we establish reference spectra that can be used to determine the different glycoforms present in heterogeneously glycosylated commercial RNase B.
Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives
Authors: Lauria Antonino , La Monica Gabriele , Terenzi Alessio , Mannino Giuseppe , Bonsignore Riccardo , Bono Alessia , Almerico Anna Maria , Barone Giampaolo , Gentile Carla , Martorana Annamaria
Published: July 2021

Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are characterized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. The stabilization of G-quadruplex sequences with small molecules is considered a promising strategy in anticancer targeted therapy. Methods: Molecular virtual screening allowed us identifying novel symmetric bifunctionalized naphtho[1,2-b:8,7-b’]dithiophene ligands as interesting candidates targeting h-Telo and c-MYC G-quadruplexes. A set of unexplored naphtho-dithiophene derivatives has been synthesized and biologically tested through in vitro antiproliferative assays and spectroscopic experiments in solution. Results: The analysis of biological and spectroscopic data highlighted noteworthy cytotoxic effects on HeLa cancer cell line (GI50 in the low μM range), but weak interactions with G-quadruplex c-MYC promoter. Conclusions: The new series of naphtho[1,2-b:8,7-b’]dithiophene derivatives, bearing the pharmacophoric assumptions necessary to stabilize G-quadruplexes, have been designed and successfully synthesized. The interesting antiproliferative results supported by computer aided rational approaches suggest that these studies are a significant starting point for a lead optimization process and the isolation of a more efficacious set of G-quadruplexes stabilizers.
Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study
Authors: Lefranc Benjamin , Alim Karima , Neveu Cindy , Le Marec Olivier , Dubessy Christophe , Boutin Jean A. , Chuquet Julien , Vaudry David , Prévost Gaëtan , Picot Marie , Vaudry Hubert , Chartrel Nicolas , Leprince Jérôme
Published: July 2021

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. Herein, the pharmacological profile of a homogenous library of QRFPR-targeting peptide derivatives was investigated in vitro on human QRFPR-transfected cells with the aim to provide possible insights into the structural determinants of the Phe residues to govern receptor activation. Our work advocates to include in next generations of 26RFa(20–26)-based QRFPR agonists effective substitutions for each Phe unit, i.e., replacement of the Phe22 residue by a constrained 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid moiety, and substitution of both Phe24 and Phe26 by their para-chloro counterpart. Taken as a whole, this study emphasizes that optimized modifications in the C-terminal part of 26RFa are mandatory to design selective and potent peptide agonists for human QRFPR.
Fe3O4/Graphene Composite Anode Material for Fast-Charging Li-Ion Batteries
Authors: Staffolani Antunes , Darjazi Hamideh , Carbonari Gilberto , Maroni Fabio , Gabrielli Serena , Nobili Francesco
Published: July 2021

Composite anode material based on Fe3O4 and reduced graphene oxide is prepared by base-catalysed co-precipitation and sonochemical dispersion. Structural and morphological characterizations demonstrate an effective and homogeneous embedding of Fe3O4 nanoparticles in the carbonaceous matrix. Electrochemical characterization highlights specific capacities higher than 1000 mAh g−1 at 1C, while a capacity of 980 mAhg−1 is retained at 4C, with outstanding cycling stability. These results demonstrate a synergistic effect by nanosize morphology of Fe3O4 and inter-particle conductivity of graphene nanosheets, which also contribute to enhancing the mechanical and cycling stability of the electrode. The outstanding capacity delivered at high rates suggests a possible application of the anode material for high-power systems.
Controlled Fabrication of Quality ZnO NWs/CNTs and ZnO NWs/Gr Heterostructures via Direct Two-Step CVD Method
Authors: Schaper Nicholas , Alameri Dheyaa , Kim Yoosuk , Thomas Brian , McCormack Keith , Chan Mathew , Divan Ralu , Gosztola David J. , Liu Yuzi , Kuljanishvili Irma
Published: July 2021

A novel and advanced approach of growing zinc oxide nanowires (ZnO NWs) directly on single-walled carbon nanotubes (SWCNTs) and graphene (Gr) surfaces has been demonstrated through the successful formation of 1D–1D and 1D–2D heterostructure interfaces. The direct two-step chemical vapor deposition (CVD) method was utilized to ensure high-quality materials’ synthesis and scalable production of different architectures. Iron-based universal compound molecular ink was used as a catalyst in both processes (a) to form a monolayer of horizontally defined networks of SWCNTs interfaced with vertically oriented ZnO NWs and (b) to grow densely packed ZnO NWs directly on a graphene surface. We show here that our universal compound molecular ink is efficient and selective in the direct synthesis of ZnO NWs/CNTs and ZnO NWs/Gr heterostructures. Heterostructures were also selectively patterned through different fabrication techniques and grown in predefined locations, demonstrating an ability to control materials’ placement and morphology. Several characterization tools were employed to interrogate the prepared heterostructures. ZnO NWs were shown to grow uniformly over the network of SWCNTs, and much denser packed vertically oriented ZnO NWs were produced on graphene thin films. Such heterostructures can be used widely in many potential applications, such as photocatalysts, supercapacitors, solar cells, piezoelectric or thermal actuators, as well as chemical or biological sensors.
Nanostructural Materials with Rare Earth Ions: Synthesis, Physicochemical Characterization, Modification and Applications
Authors: Wiglusz Rafal J.
Published: July 2021

The success of nanotechnology in the field of physical, chemical and medical sciences has started revolutionizing the drug delivery science and theranostics (therapy and diagnostics) [...]
Liquid Lipids Act as Polymorphic Modifiers of Tristearin-Based Formulations Produced by Melting Technologies
Authors: Bertoni Serena , Passerini Nadia , Albertini Beatrice
Published: July 2021

Despite the growing interest in lipid-based formulations, their polymorphism is still a challenge in the pharmaceutical industry. Understanding and controlling the polymorphic behavior of lipids is a key element for achieving the quality and preventing stability issues. This study aims to evaluate the impact of different oral-approved liquid lipids (LL) on the polymorphism, phase transitions and structure of solid lipid-based formulations and explore their influence on drug release. The LL investigated were isopropyl myristate, ethyl oleate, oleic acid, medium chain trigycerides, vitamin E acetate, glyceryl monooleate, lecithin and sorbitane monooleate. Spray-congealing was selected as an example of a melting-based solvent-free manufacturing method to produce microparticles (MPs) of tristearin (Dynasan®118). During the production process, tristearin MPs crystallized in the metastable α-form. Stability studied evidenced a slow phase transition to the stable β-polymorph overtime, with the presence of the α-form still detected after 60 days of storage at 25 °C. The addition of 10% w/w of LL promoted the transition of tristearin from the α-form to the stable β-form with a kinetic varying from few minutes to days, depending on the specific LL. The combination of various techniques (DSC, X-ray diffraction analysis, Hot-stage polarized light microscopy, SEM) showed that the addition of LL significantly modified the crystal structure of tristearin-based formulations at different length scales. Both the polymorphic form and the LL addition had a strong influence on the release behavior of a model hydrophilic drug (caffeine). Overall, the addition of LL can be considered an interesting approach to control triglyceride crystallization in the β-form. From the industrial viewpoint, this approach might be advantageous as any polymorphic change will be complete before storage, hence enabling the production of stable lipid formulations.
Advances in Endoscopic Photoacoustic Imaging
Authors: Li Yan , Lu Gengxi , Zhou Qifa , Chen Zhongping
Published: July 2021

Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong light scattering and attenuation. Endoscopic PA technology enables direct delivery of excitation light into the interior of a hollow organ or cavity of the body for functional and molecular PA imaging of target tissue. Various endoscopic PA probes have been developed for different applications, including the intravascular imaging of lipids in atherosclerotic plaque and endoscopic imaging of colon cancer. In this paper, the authors review representative probe configurations and corresponding preclinical applications. In addition, the potential challenges and future directions of endoscopic PA imaging are discussed.
Obituary for Prof. Yuri Raizer
Authors: Starikovskiy Andrey , Shneider Mikhail
Published: July 2021

With deep sadness we inform that on 25 June 2021 our teacher and colleague Yuri Raizer passed away [...]
Introduction to Special Issue: Exploring Sikh Traditions and Heritage
Authors: Singh Pashaura
Published: July 2021

It was quite an exciting moment when the Religions Editorial Office reached out to me to be a guest editor of a Special Issue (SI) on a broad theme of “Exploring Sikh Traditions and Heritage” for the celebrated Open Access Online Journal, Religions [...]
Introduction to the Special Issue “Marriage, Intimacy, Gender and Islam in Southeast Asia”
Authors: Mohamad Maznah
Published: July 2021

The topic of gender and Islam in Southeast Asia has been much studied [...]
Psychometric Properties of the Clergy Suicide Prevention Competencies Developmental Rubric and Faith Leaders’ Readiness to Address Suicide Stigma
Authors: Mason Karen , Yoon Ji-Young , Taylor Elizabeth , Korver David , Hu Yuan
Published: July 2021

Faith leaders (FL) have a key role in suicide prevention. One of their roles is to address suicide stigma in faith communities. Are they ready to do so? The Clergy Suicide Prevention Skills Developmental Rubric (CSPCDR) was developed to understand and assess clergy suicide prevention skills. The psychometric properties of the CSPCDR are reported in order to assess FL’ readiness to address suicide stigma. Sample 1, 186 Protestant seminary students completed the CSPCDR twice, resulting in Pearson’s r = 0.77. Sample 2, 187 Protestant clergy and lay ministers completed the CSPCDR before and after one of eight trainings to test construct validity; the CSPCDR performed as expected. Results suggest how to expand FL’ readiness to address suicide stigma in faith communities.
UCalib: Cameras Autocalibration on Coastal Video Monitoring Systems
Authors: Simarro Gonzalo , Calvete Daniel , Souto Paola
Published: July 2021

Following the path set out by the “Argus” project, video monitoring stations have become a very popular low cost tool to continuously monitor beaches around the world. For these stations to be able to offer quantitative results, the cameras must be calibrated. Cameras are typically calibrated when installed, and, at best, extrinsic calibrations are performed from time to time. However, intra-day variations of camera calibration parameters due to thermal factors, or other kinds of uncontrolled movements, have been shown to introduce significant errors when transforming the pixels to real world coordinates. Departing from well-known feature detection and matching algorithms from computer vision, this paper presents a methodology to automatically calibrate cameras, in the intra-day time scale, from a small number of manually calibrated images. For the three cameras analyzed here, the proposed methodology allows for automatic calibration of >90% of the images in favorable conditions (images with many fixed features) and ∼40% in the worst conditioned camera (almost featureless images). The results can be improved by increasing the number of manually calibrated images. Further, the procedure provides the user with two values that allow for the assessment of the expected quality of each automatic calibration. The proposed methodology, here applied to Argus-like stations, is applicable e.g., in CoastSnap sites, where each image corresponds to a different camera.
Estimation of Northern Hardwood Forest Inventory Attributes Using UAV Laser Scanning (ULS): Transferability of Laser Scanning Methods and Comparison of Automated Approaches at the Tree- and Stand-Level
Authors: Vandendaele Bastien , Fournier Richard A. , Vepakomma Udayalakshmi , Pelletier Gaetan , Lejeune Philippe , Martin-Ducup Olivier
Published: July 2021

UAV laser scanning (ULS) has the potential to support forest operations since it provides high-density data with flexible operational conditions. This study examined the use of ULS systems to estimate several tree attributes from an uneven-aged northern hardwood stand. We investigated: (1) the transferability of raster-based and bottom-up point cloud-based individual tree detection (ITD) algorithms to ULS data; and (2) automated approaches to the retrieval of tree-level (i.e., height, crown diameter (CD), DBH) and stand-level (i.e., tree count, basal area (BA), DBH-distribution) forest inventory attributes. These objectives were studied under leaf-on and leaf-off canopy conditions. Results achieved from ULS data were cross-compared with ALS and TLS to better understand the potential and challenges faced by different laser scanning systems and methodological approaches in hardwood forest environments. The best results that characterized individual trees from ULS data were achieved under leaf-off conditions using a point cloud-based bottom-up ITD. The latter outperformed the raster-based ITD, improving the accuracy of tree detection (from 50% to 71%), crown delineation (from R2 = 0.29 to R2 = 0.61), and prediction of tree DBH (from R2 = 0.36 to R2 = 0.67), when compared with values that were estimated from reference TLS data. Major improvements were observed for the detection of trees in the lower canopy layer (from 9% with raster-based ITD to 51% with point cloud-based ITD) and in the intermediate canopy layer (from 24% with raster-based ITD to 59% with point cloud-based ITD). Under leaf-on conditions, LiDAR data from aerial systems include substantial signal occlusion incurred by the upper canopy. Under these conditions, the raster-based ITD was unable to detect low-level canopy trees (from 5% to 15% of trees detected from lower and intermediate canopy layers, respectively), resulting in a tree detection rate of about 40% for both ULS and ALS data. The cylinder-fitting method used to estimate tree DBH under leaf-off conditions did not meet inventory standards when compared to TLS DBH, resulting in RMSE = 7.4 cm, Bias = 3.1 cm, and R2 = 0.75. Yet, it yielded more accurate estimates of the BA (+3.5%) and DBH-distribution of the stand than did allometric models −12.9%), when compared with in situ field measurements. Results suggest that the use of bottom-up ITD on high-density ULS data from leaf-off hardwood forest leads to promising results when estimating trees and stand attributes, which opens up new possibilities for supporting forest inventories and operations.
Spatio-Temporal Characteristics and Driving Factors of the Foliage Clumping Index in the Sanjiang Plain from 2001 to 2015
Authors: Hu Kehong , Zhang Zhen , Fang Hongliang , Lu Yijie , Gu Zhengnan , Gao Min
Published: July 2021

The Sanjiang Plain is the largest agricultural reclamation area and the biggest marsh area in China. The regional vegetation coverage in this area is vital to local ecological systems, and vegetation growth is affected by natural and anthropogenic factors. The clumping index (CI) is of great significance for land surface models and obtaining information on other vegetation structures. However, most existing ecological models and the retrieval of other vegetation structures do not consider the spatial and temporal variations of CI, and few studies have focused on detecting factors that influence the spatial differentiation of CI. To address these issues, this study investigated the spatial and temporal characteristics of foliage CI in the Sanjiang Plain, analysing the correlation between CI and leaf area index (LAI) through multiple methods (such as Theil−Sen trend analysis, the Mann−Kendall test, and the correlation coefficient) based on the 2001−2015 Chinese Academy of Sciences Clumping Index (CAS CI) and Global LAnd Surface Satellite Leaf Area Index (GLASS LAI). The driving factors of the spatial differentiation of CI were also investigated based on the geographical detector model (GDM) with natural data (including the average annual temperature, annual precipitation, elevation, slope, aspect, vegetation type, soil type, and geomorphic type) and anthropogenic data (the land use type). The results showed that (1) the interannual variation of foliage CI was not obvious, but the seasonal variation was obvious in the Sanjiang Plain from 2001 to 2015; (2) the spatial distribution of the multiyear mean CI of each season in the Sanjiang Plain was similar to the spatial distribution of the land use type, and the CI decreased slightly with increases in elevation; (3) the correlation between the growing season mean CI (CIGS) and the growing season mean LAI (LAIGS) time series was not significant, but their spatial distributions were negatively correlated; (4) topographic factors (elevation and slope) and geomorphic type dominated the spatial differentiation of foliage CI in the Sanjiang Plain, and the interactions between driving factors enhanced their explanatory power in terms of the spatial distribution of foliage CI. This study can help improve the accuracy of the retrieval of other vegetation structures and the simulation of land surface models in the Sanjiang Plain, providing invaluable insight for the analysis of the spatial and temporal variations of vegetation based on CI. Moreover, the results of this study support a theoretical basis for understanding the explanatory power of natural and anthropogenic factors in the spatial distribution of CI, along with its driving mechanism.
Waking Up In the Morning (WUIM): A Smart Learning Environment for Students with Learning Difficulties
Authors: Kaimara Polyxeni , Deliyannis Ioannis , Oikonomou Andreas , Fokides Emmanuel
Published: July 2021

Effectiveness, efficiency, scalability, autonomy, engagement, flexibility, adaptiveness, personalization, conversationality, reflectiveness, innovation, and self-organization are some of the fundamental features of smart environments. Smart environments are considered a good learning practice for formal and informal education; however, it is important to point out the pedagogical approaches on which they are based. Smart learning environments (SLEs) underline the flexibility of eclectic pedagogy that places students at the center of any educational process and takes into account the diversity in classrooms. Thus, SLEs incorporate pedagogical principles derived from (1) traditional learning theories, e.g., behaviorism and constructivism, (2) contemporary pedagogical philosophy, e.g., differentiated teaching and universal design for learning, (3) theories that provide specific instructions for educational design, e.g., cognitive theory of multimedia learning and gamification of learning. The innovative concept of transmedia learning is an eclectic pedagogical approach, which in addition to learning principles, blends all available media so far. WUIM is a transmedia program for training independent living skills aimed primarily at children with learning disabilities, which emerged from the composition of pedagogical theories, traditional educational materials and cutting-edge technologies such as augmented and virtual reality, and art-based production methodologies. This paper outlines the development of WUIM, from the prototyping presented at the 4th International Conference in Creative Writing (2019) to the Alpha and Beta stages, including user and expert evaluations.
Viktor Frankl e Martin Buber, Deus eclipsado ou inconsciente
Authors: Carvalho José Mauricio de
Published: July 2021

Neste artigo vamos examinar a influência das teses do filósofo Martin Buber na antropologia e psicologia de Viktor Frankl. Trata-se de influência amplamente admitida pelo psiquiatra. Começa-se indicando como as teses fundamentais de Buber sobre a intersubjetividade foram apreendidas e mencionadas por Frankl para, em seguida, mostrar como essas ideias abrem espaço para uma interpretação psicológica de um fenômeno histórico e filosófico, o do eclipse de Deus da consciência do homem ocidental. O que se procura indicar é que a noção Deus inconsciente corresponde à leitura psicológica do conceito buberiano de eclipse de Deus.

 

Palavras-chave: Inconsciente espiritual – Eclipse de Deus – Psicologia
O sistema financeiro nacional apresentado em um livro de educação financeira
Authors: Oliveira Ana Paula Teles
Published: July 2021

A finalidade deste artigo é apresentar um recorte dos resultados da pesquisa “Um estudo sobre educação financeira” que tem como um dos seus objetivos traçar o panorama dos assuntos tratados sobre esta questão. Metodologicamente, consiste em um trabalho documental. Após estudar o modelo conceitual do letramento financeiro apresentado por Hung, Parker e Yoong, fizemos uma análise no livro Educação Financeira nas Escolas, Bloco 3, Ensino Médio que pertencente ao programa do governo, para entender quais são os conteúdos tratados e quais as competências propostas pelos autores. Aqui apresentamos a categoria denominada Sistema financeiro nacional e as três competências recomendadas por eles. Como concluímos existir uma limitação das competências que poderiam ser desenvolvidas, adaptamos outras três competências do material do Jump$tart relacionada à literacia financeira pessoal.
Educação financeira: Sequência didática com o aplicativo “Minhas Economias”
Authors: Ramos Maria do Socorro Ferreira , Moura Patrícia de Souza , Lavor Otávio Paulino
Published: July 2021

A educação financeira é um dos conhecimentos relevantes na vida pessoal e profissional, visto que se aplica em diversas áreas e pode ser entendida como o processo de ensino e aprendizagem para o desenvolvimento da consciência crítico-reflexiva diante das questões financeiras dentre as quais destacam-se o consumo, o planejamento, o investimento. Nesse sentido, pode-se pensar nessa temática aplicando uma sequência didática com o uso de um aplicativo que busque a motivação para aprendizagem da educação financeira em uma turma de ensino médio no Estado do Ceará. Os resultados revelam que os alunos estão disponíveis para um diálogo de aprendizagens e que ao serem submetidos a novos conhecimentos, mostraram-se motivados pelas tecnologias adquirindo a percepção do consumo consciente e planejamento financeiro.  O objetivo desse trabalho é encorajar a reflexão e prática docentes para incluir situações favorecedoras da educação financeira mediada por recursos tecnológicos que estimulem a tomada consciente de decisões.