bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence, Risk Factors, and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery: A Historical Cohort
Authors: Godi Ilaria , Feltracco Paolo , Lorenzoni Giulia , Antonelli Alessio , Salvador Renato , Gregori Dario , Tiberio Ivo , Valmasoni Michele
Published: April 2024

Background: Limited data exist on postoperative acute kidney injury (AKI) in patients who have undergone esophageal cancer surgery. The purpose of this study was to evaluate the incidence, risk factors, and consequences of postoperative acute kidney after esophagectomy. Methods: This was a retrospective cohort study. The study was conducted in a tertiary specialized cancer center in Italy. All patients undergoing elective esophageal cancer surgery between 2016 and 2021 were included in the study. AKI was defined according to Kidney Disease Improving Global Outcomes criteria (both serum creatinine and urine output), within 48 h after surgery. Preoperative and intraoperative data were registered. We also collected data concerning progression of AKI, need for renal replacement therapy, mortality, and medical (pulmonary, cardiovascular, septic) and surgical complications within 30 days from surgery, as well as length of hospital stay. Results: Incidence of postoperative AKI was 32%. The independent risk factors were body mass index and the use of an invasive surgical approach. Persistent AKI accounted for 15% of the cases and it was associated with increased risk of major cardiovascular events (odds ratio 4.14, 95% CI 1.05–15.8, p-value 0.036), pulmonary complications (OR 3.67, 95% CI 1.04–14.9, p-value 0.050), and increased length of hospital stay (AME 7.2, 0.5–13.9, p-value 0.035). Conclusions: Postoperative AKI is common after esophageal cancer surgery. BMI and a totally invasive surgical approach are independent risk factors. Persistent AKI lasting more than 48 h increased the risk for any cardiovascular or pulmonary complications, with prolonged length of hospital stay.
Value Perception Analysis in the Brazilian Company of Research and Industrial Innovation
Authors: Moreira Isabela Evora , Fettermann Diego de Castro , Grubisic Viviane Vasconcellos Ferreira
Published: April 2024

This study aims to analyze the perceived value of services provided by the Brazilian Company of Research and Industrial Innovation (EMBRAPII) to its contracting ministries and institutional partners. It utilizes the theory of value perception analysis and Constructivist Multi-criteria Decision Analysis to identify critical elements for evaluating EMBRAPII’s contracting organizations. Brainstorming sessions with experts led to the identification of five criteria and 14 sub-criteria. These criteria include a relationship with EMBRAPII, a signed agreement, EMBRAPII’s reputation, technical capacity, and the ability to adapt to changes. Data were entered into the second version of the MyMCDA-C software for value perception analysis. The findings showed a positive perceived value, with the best-performing sub-criteria relating to the organization’s reputation and the agreement signed. The study concludes that EMBRAPII needs to improve in areas such as adapting to change, the adequacy of its proposals for distinct types of partnership, and social media positioning. However, the contracting organizations generally support EMBRAPII’s direction and proposed solutions.
A New and Lightweight R-Peak Detector Using the TEDA Evolving Algorithm
Authors: Silva Lucileide M. D. da , Silva Sérgio N. , Souza Luísa C. de , Azevedo Karolayne S. de , Guedes Luiz Affonso , Fernandes Marcelo A. C.
Published: April 2024

The literature on ECG delineation algorithms has seen significant growth in recent decades. However, several challenges still need to be addressed. This work aims to propose a lightweight R-peak-detection algorithm that does not require pre-setting and performs classification on a sample-by-sample basis. The novelty of the proposed approach lies in the utilization of the typicality eccentricity detection anomaly (TEDA) algorithm for R-peak detection. The proposed method for R-peak detection consists of three phases. Firstly, the ECG signal is preprocessed by calculating the signal’s slope and applying filtering techniques. Next, the preprocessed signal is inputted into the TEDA algorithm for R-peak estimation. Finally, in the third and last step, the R-peak identification is carried out. To evaluate the effectiveness of the proposed technique, experiments were conducted on the MIT-BIH arrhythmia database (MIT-AD) for R-peak detection and validation. The results of the study demonstrated that the proposed evolutive algorithm achieved a sensitivity (Se in %), positive predictivity (+P in %), and accuracy (ACC in %) of 95.45%, 99.61%, and 95.09%, respectively, with a tolerance (TOL) of 100 milliseconds. One key advantage of the proposed technique is its low computational complexity, as it is based on a statistical framework calculated recursively. It employs the concepts of typicity and eccentricity to determine whether a given sample is normal or abnormal within the dataset. Unlike most traditional methods, it does not require signal buffering or windowing. Furthermore, the proposed technique employs simple decision rules rather than heuristic approaches, further contributing to its computational efficiency.
Influence of the COVID-19 Pandemic on Medical Management and on Healthcare Delivery of Immune-Mediated Rheumatic and Musculoskeletal Diseases during the First Pandemic Period February to July 2020: A Systematic Review
Authors: Schlegel Marco , Bachmann Stefan
Published: April 2024

(1) Background and Objectives: The COVID-19 pandemic influenced the management of patients with immune-mediated rheumatic and musculoskeletal diseases (imRMDs) in various ways. The goal of our systematic review was to determine the influence of the first period of the COVID-19 pandemic (February 2020 to July 2020) on the management of imRMDs regarding the availability of drugs, adherence to therapy and therapy changes and on healthcare delivery. (2) Materials and Methods: We conducted a systematic literature search of PubMed, Cochrane and Embase databases (carried out 20–26 October 2021), including studies with adult patients, on the influence of the COVID-19 pandemic on the management of imRMDs. There were no restrictions regarding to study design except for systematic reviews and case reports that were excluded as well as articles on the disease outcomes in case of SARS-CoV-2 infection. Two reviewers screened the studies for inclusion, and in case of disagreement, a consensus was reached after discussion. (3) Results: A total of 5969 potentially relevant studies were found, and after title, abstract and full-text screening, 34 studies were included with data from 182,746 patients and 2018 rheumatologists. The non-availability of drugs (the impossibility or increased difficulty to obtain a drug), e.g., hydroxychloroquine and tocilizumab, was frequent (in 16–69% of patients). Further, medication non-adherence was reported among patients with different imRMDs and between different drugs in 4–46% of patients. Changes to preexisting medication were reported in up to 33% of patients (e.g., reducing the dose of steroids or the cessation of biological disease-modifying anti-rheumatic drugs). Physical in-office consultations and laboratory testing decreased, and therefore, newly implemented remote consultations (particularly telemedicine) increased greatly, with an increase of up to 80%. (4) Conclusions: The COVID-19 pandemic influenced the management of imRMDs, especially at the beginning. The influences were wide-ranging, affecting the availability of pharmacies, adherence to medication or medication changes, avoidance of doctor visits and laboratory testing. Remote and telehealth consultations were newly implemented. These new forms of healthcare delivery should be spread and implemented worldwide to routine clinical practice to be ready for future pandemics. Every healthcare service provider treating patients with imRMDs should check with his IT provider how these new forms of visits can be used and how they are offered in daily clinical practice. Therefore, this is not only a digitalization topic but also an organization theme for hospitals or outpatient clinics.
Disparities and Outcomes in the First and Second Year of the Pandemic on Events of Acute Myocardial Infarction in Coronavirus Disease 2019 Patients
Authors: Dhaliwal Jasninder Singh , Sekhon Manraj S. , Rajotia Arush , Dang Ashujot K. , Singh Prabh Partap , Bilal Maham , Sakthivel Hemamalini , Ahmed Raheel , Verma Renuka , Ramphul Kamleshun , Sethi Prabhdeep S.
Published: April 2024

Background and Objectives: Coronavirus disease 2019 (COVID-19) caused several cardiovascular complications, including acute myocardial infarction (AMI), in infected patients. This study aims to understand the overall trends of AMI among COVID-19 patients during the first two years of the pandemic and the disparities and outcomes between the first and second years. Materials and Methods: The retrospective analysis was conducted via the 2020 and 2021 National Inpatient Sample (NIS) database for hospitalizations between April 2020 and December 2021 being analyzed for adults with a primary diagnosis of COVID-19 who experienced events of AMI. A comparison of month-to-month events of AMI and mortality of AMI patients with concomitant COVID-19 was made alongside their respective patient characteristics. Results: Out of 2,541,992 COVID-19 hospitalized patients, 3.55% experienced AMI. The highest rate of AMI was in December 2021 (4.35%). No statistical differences in trends of AMI mortality were noted over the 21 months. AMI cases in 2021 had higher odds of undergoing PCI (aOR 1.627, p < 0.01). They experienced higher risks of acute kidney injury (aOR 1.078, p < 0.01), acute ischemic stroke (aOR 1.215, p < 0.01), cardiac arrest (aOR 1.106, p < 0.01), need for mechanical ventilation (aOR 1.133, p < 0.01), and all-cause mortality (aOR 1.032, 95% CI 1.001–1.064, p = 0.043). Conclusions: The incidence of AMI among COVID-19 patients fluctuated over the 21 months of this study, with a peak in December 2021. COVID-19 patients reporting AMI in 2021 experienced higher overall odds of multiple complications, which could relate to the exhaustive burden of the pandemic in 2021 on healthcare, the changing impact of the virus variants, and the hesitancy of infected patients to seek care.
Prevalence of FMS Diagnosis According to ACR 2016 Revised Criteria in a Pain Therapy Centre in Italy: Observational Study
Authors: Schweiger Vittorio , Martini Alvise , Nizzero Marta , Bonora Eleonora , Del Balzo Giovanna , Gottin Leonardo , Torroni Lorena , Polati Luca , Zuliani Giada , Secchettin Erica , Polati Enrico
Published: April 2024

Background and Objectives: Fibromyalgia syndrome (FMS) is a multifaceted disease with a strong preference for the female sex. It is characterised by chronic widespread pain, sleep–wake disorders, fatigue, cognitive disturbances, and several other somatic symptoms. Materials and Methods: In this prospective observational study, we analysed data regarding 302 patients who were referred to our pain centre for a first clinical assessment evaluation and were then inspected for the physician-based 2016 revision of the ACR diagnostic criteria for FMS, regardless of the final diagnosis previously made by the pain therapist. Results: Among the 280 patients who adhered to the 2016 ACR questionnaire, 20.3% displayed positive criteria for FMS diagnosis. The level of agreement between the FMS discharge diagnosis made by the pain clinician and the ACR 2016 criteria-positivity was moderate (kappa = 0.599, with moderate agreement set at a kappa value of 0.6). Only four patients (1.7%) diagnosed as suffering from FMS at discharge did not satisfy the minimal 2016 ACR diagnostic criteria. Conclusions: This prospective observational study confirmed the diagnostic challenge with FMS, as demonstrated by the moderate grade of agreement between the FMS diagnosis at discharge and the positivity for 2016 ACR criteria. In our opinion, the use of widely accepted diagnostic guidelines should be implemented in clinical scenarios and should become a common language among clinicians who evaluate and treat patients reporting widespread pain and FMS-suggestive symptoms. Further methodologically stronger studies will be necessary to validate our observation.
Atomic Force Microscopy Study of the Long-Term Effect of the Glycerol Flow, Stopped in a Coiled Heat Exchanger, on Horseradish Peroxidase
Authors: Ivanov Yuri D. , Shumov Ivan D. , Kozlov Andrey F. , Valueva Anastasia A. , Ershova Maria O. , Ivanova Irina A. , Ableev Alexander N. , Tatur Vadim Y. , Lukyanitsa Andrei A. , Ivanova Nina D. , Ziborov Vadim S.
Published: April 2024

Glycerol is employed as a functional component of heat-transfer fluids, which are of use in both bioreactors and various biosensor devices. At the same time, flowing glycerol was reported to cause considerable triboelectric effects. Herein, by using atomic force microscopy (AFM), we have revealed the long-term effect of glycerol flow, stopped in a ground-shielded coiled heat exchanger, on horseradish peroxidase (HRP) adsorption on mica. Namely, the solution of HRP was incubated in the vicinity of the side of the cylindrical coil with stopped glycerol flow, and then HRP was adsorbed from this solution onto a mica substrate. This incubation has been found to markedly increase the content of aggregated enzyme on mica—as compared with the control enzyme sample. We explain the phenomenon observed by the influence of triboelectrically induced electromagnetic fields of non-trivial topology. The results reported should be further considered in the development of flow-based heat exchangers of biosensors and bioreactors intended for operation with enzymes.
Mechanistic Assessment of Cardiovascular State Informed by Vibroacoustic Sensors
Authors: Zare Ali , Wittrup Emily , Najarian Kayvan
Published: April 2024

Monitoring blood pressure, a parameter closely related to cardiovascular activity, can help predict imminent cardiovascular events. In this paper, a novel method is proposed to customize an existing mechanistic model of the cardiovascular system through feature extraction from cardiopulmonary acoustic signals to estimate blood pressure using artificial intelligence. As various factors, such as drug consumption, can alter the biomechanical properties of the cardiovascular system, the proposed method seeks to personalize the mechanistic model using information extracted from vibroacoustic sensors. Simulation results for the proposed approach are evaluated by calculating the error in blood pressure estimates compared to ground truth arterial line measurements, with the results showing promise for this method.
A Signal-Processing-Based Simulation System for High-End Stereo Headsets
Authors: Zuccante Anna , Fiordelmondo Alessandro , Bontempi Pierluigi , Canazza Sergio
Published: April 2024

In recent years, headphones have become increasingly popular worldwide. There are numerous models on the market today, varying in technical characteristics and offering different listening experiences. This article presents an application for simulating the sound response of specific headphone models by physically wearing others. In the future, for example, this application could help to guide people who already own a pair of headphones during the decision-making process of purchasing a new headphone model. However, the potential fields of application are much broader. An in-depth study of digital signal processing was carried out with the implementation of a computational model. Prior to this, an analysis was performed on impulse response measurements of specific headphones, which allowed for a better understanding of the behavior of each set of headphones. Finally, an evaluation of the entire system was conducted through a listening test. The analysis of the results showed that the software works reasonably well in replicating the target headphones. We hope that this work will stimulate further efforts in the same direction.
Impact of Impedance Levels on Recording Quality in Flexible Neural Probes
Authors: Han Juyeon , Choi Jungsik , Jeong Hyeonyeong , Park Daerl , Cheong Eunji , Sung Jaesuk , Choi Heon-Jin
Published: April 2024

Flexible neural probes are attractive emerging technologies for brain recording because they can effectively record signals with minimal risk of brain damage. Reducing the electrode impedance of the probe before recording is a common practice of many researchers. However, studies investigating the impact of low impedance levels on high-quality recordings using flexible neural probes are lacking. In this study, we electrodeposited Pt onto a commercial flexible polyimide neural probe and investigated the relationship between the impedance level and the recording quality. The probe was inserted into the brains of anesthetized mice. The electrical signals of neurons in the brain, specifically the ventral posteromedial nucleus of the thalamus, were recorded at impedance levels of 50, 250, 500 and 1000 kΩ at 1 kHz. The study results demonstrated that as the impedance decreased, the quality of the signal recordings did not consistently improve. This suggests that extreme lowering of the impedance may not always be advantageous in the context of flexible neural probes.
Variations in Essential Oil Biological Activities of Female Cones at Different Developmental Stages from Azorean Cryptomeria japonica (Thunb. ex L.f.) D. Don (Cupressaceae)
Authors: Janeiro Alexandre , Lima Ana , Arruda Filipe , Wortham Tanner , Rodrigues Tânia , Baptista José , Lima Elisabete
Published: April 2024

In the Azores Archipelago, Cryptomeria japonica is, currently, the most cultivated forestry tree for timber production, landscaping, and gardening, generating large amounts of foliage waste that is used for local essential oils (EOs) production. However, the existing literature on the biological potential of EOs from different C. japonica foliage parts, such as female cones (FC), remains limited. Thus, in the present study, EOs extracted by hydrodistillation from Azorean C. japonica immature and mature FC (IFC and MFC), as well as some major EO components, were screened for their: (i) antioxidant capacity, evaluated by DPPH free-radical-scavenging activity (FRSA) and β-carotene-linoleic acid bleaching activity (BCBA), (ii) antimicrobial activities, assessed by the disc diffusion method against eight bacteria and one fungus, and (iii) toxicity against Artemia salina. Among both FC EO samples, the IFC EO exhibited the best DPPH–FRSA, BCBA, and growth inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Penicillium italicum, as well as a slightly increased toxic potential, due to their differential compositions, as assessed by GC–MS analysis. Thus, the FC’s maturation process decreased their EOs’ bioactivities. In conclusion, this finding could help in determining the optimal developmental stage for enhancing the antioxidant and antimicrobial compounds content in FC EOs. In turn, this contributes to increasing the commercial potential of C. japonica’s EO industry.
Is the Bulbar Urethral Stricture a Single and Uniform Disease?
Authors: Tabei Tadashi , Horiguchi Akio , Shinchi Masayuki , Hirano Yusuke , Ojima Kenichiro , Ito Keiichi , Azuma Ryuichi
Published: April 2024

Objectives: Proximal and distal bulbar urethral strictures (BUS) have different disease characteristics and require different treatment strategies despite being regarded as a single condition. To clarify the differences, we analyzed our database by distinguishing the two types of BUS. Methods: We retrospectively reviewed the data of 196 patients with BUS who underwent urethroplasty at the National Defense Medical College (Japan) between August 2004 and March 2022. We divided patients into proximal (group 1) or distal (group 2) groups based on the stricture segment and compared patient background and surgical techniques for each group. We assessed whether the stricture segment was an independent predictive factor for substitution urethroplasty selection using multivariate logistic regression analysis. The recurrence rates were calculated and compared using the Kaplan–Meier method and log-rank test, respectively. Results: Patients in group 1 had a less frequent non-obliterated lumen (73% vs. 94%, p = 0.020) and significantly shorter strictures (10 mm vs. 23 mm, p < 0.001) more frequently caused by external traumas (47% vs. 26%, p = 0.010) than those in group 2. Logistic regression analysis revealed that the stricture segment (distal) (p < 0.001), stricture length (≥20 mm) (p < 0.001), ≥2 prior transurethral procedures (p = 0.030), and a non-obliterated lumen (p = 0.020) were independent predictive factors for substitution urethroplasty. However, the recurrence rate (p = 0.18) did not significantly differ between the two groups. Conclusions: Proximal and distal BUS have substantially different anatomical characteristics and etiologies and require different reconstructive techniques.
Sustainable-by-Design Approach of Active Catalysts to Produce Reactive Oxygen Species in Water Matrices
Authors: Prete Prisco
Published: April 2024

An overview of the latest advances in the design of active catalysts with the ability to promote (photo) Fenton processes in water from a Green Chemistry perspective is discussed herein. A critical evaluation of the most relevant advances has been disclosed, and a brief perspective is presented about what is needed to fill the gap of knowledge in this field.
Ultrasound examination of the gonads of the african clary catfish in industrial aquaculture
Authors:   Ulyanovsk State Agrarian University, Russia, Ulyanovsk, Turaeva E.E. , Romanova E.M. ,   Ulyanovsk State Agrarian University, Russia, Ulyanovsk, Lyubomirova V.N. ,   Ulyanovsk State Agrarian University, Russia, Ulyanovsk, Shadyeva L.A. ,   Ulyanovsk State Agrarian University, Russia, Ulyanovsk, Vasiliev A.V. ,   Ulyanovsk State Agrarian University, Russia, Ulyanovsk
Published: April 2024

The article is devoted to ultrasound examination of the gonads of the African clary catfish. Data on the state of the reproductive system of fish are the basis for the formation of a high-quality breeding stock. In mature fish, the state of the gonads is an informative indicator and reflects the general physiological state of the body. The object of the study was the African clarias catfish (Clarias gariepinus). A group of 10 individuals, including 5 males and 5 females, was selected for the work. The gonads were examined using the Mindray DP-50 ultrasound machine. A linear ultrasonic sensor was used to assess the gonads of the African clary catfish. The study was conducted in winter 2023. The aim of the work was an ultrasound assessment of the condition, the stage of maturity of the gonads and their variability in females and males of the African clary catfish. A study of the gonads of females, which by age and weight belong to the category of sexually mature, revealed in them the signs inherent in the gonads of the IV stage of maturity. This is typical for fish in aquaculture conditions. Ultrasound diagnostics showed that the gonads of the IV completed stage of maturity, in the upper part isoechoic, are filled with hyperechoic inclusions of high density in the form of oocytes. In the lower medial part there are hypoechoic areas with low density along the entire length of the gonads. The results of ultrasound examination of the testicles of male clary catfish showed that they are of the IV stage of maturity, enclosed in a hyperechoic shell along the entire length. Both testes have a uniform hyperechogenic fine-grained structure of high density. The lobes of both testes are not the same, clearly visualized, increased density. The results of the research allow us to conclude that ultrasound diagnostics of the sex and the study of the gonads of fish can be carried out on an ongoing basis, as it is not only painless, but also a highly informative procedure. For fish species that have lost their ability to reproduce in aquaculture conditions, determining the maturity stage of gonads using ultrasound will allow for scientifically sound hormonal stimulation and fertilization.
The possibilities of using of captive and domestic broodstocks for saving of natural populations: 1. Acipenseriformes (part 1)
Authors:   St. Petersburg State University of Veterinary Medicine, St. Petersburg Department of Russian Federal Research Institute of Fisheries and Oceanography (Berg State Research Institute on Lake and River Fisheries), Russia, Saint Petersburg, Trenkler I.V.
Published: April 2024

In last years the stocks of Russian species of sturgeons decreased to critical level which can be followed by their complete extinction in nature. As a result, the number of sturgeons beginning spawning migration into rivers are extremely small, but Astrakhan sturgeon hatcheries continue release annually about 35 mln fry using own broodstocks of two types — captive and domestic ones. However the releases of offspring of domestic broodstock are extremely discussible. On one hand, creation of such broodstocks could avoid the complete extinction of natural populations of Adriatic sturgeon Acipenser naccari in Po River and European sturgeon A. sturio in Gironde estuary. On other hand, long-term practice of commercial fish farming had shown that even the accidental refugees from sea cages or fresh-water ponds caused great harm to natural populations of same species. Hatchery individuals were undergoing different selection than fish in wild nature and had poorly formed reflexes (searching for food and avoiding predators). Besides a progressive decrease in genetic diversity with each generation could be seen in such fry due to limited number of parents (the Ryman-Laikre effect). However the creation of captive and domestic broodstocks of endangerous species and subspecies (Azov beluga Huso huso maeotica, fringebarbel sturgeon Acipenser nudiventris, Sakhalin sturgeon Acipenser mikadoi) and extinct populations (Baltic sturgeon Acipenser oxyrinchus) remains the only way to release hatchery juveniles. The first part of presented review is devoted to creation and using of captive and domestic broodstocks for conservation-type sturgeon fry releases in Russia and other countries.
AUDIT TATA KELOLA TEKNOLOGI INFORMASI PADA LAYANAN AKADEMIK FAKULTAS SAINS DAN TEKNOLOGI MENGGUNAKAN COBIT 2019
Authors: Suryani Suryani , Dwinnie Zairy Cindy , Dwynne Zaira Cindya , Pramana Jeki Harya , Megawati Megawati
Published: April 2024

Perkembangan teknologi informasi mengharuskan perguruan tinggi untuk memperbarui dan meningkatkan infrastruktur teknologi informasi guna menghadapi persaingan dan memanfaatkan kemajuan zaman. Pelayanan menjadi aspek utama yang dapat memudahkan urusan publik dilingkungan perguruan tinggi. Penggunaan Framework COBIT 2019 dianggap sebagai panduan yang efektif untuk menerapkan Teknologi Informasi dalam mengelola Sistem Informasi Akademik di Fakultas Sains dan Teknologi Universitas Islam Negeri Sultan Syarif Kasim Riau. Framework ini memberikan kontribusi berharga dalam mendukung manajemen Teknologi Informasi secara menyeluruh. Penelitian ini memiliki tujuan khusus, yaitu menerapkan Framework COBIT 2019 untuk merancang tata kelola teknologi informasi yang efektif dalam pengelolaan bisnis dan teknologi. Harapannya, penelitian ini akan memberikan informasi yang relevan terkait penerapan tata kelola tersebut.

Kata kunci – Audit, COBIT 2019, Sistem Informasi Akademik
DOPAMINE AND NOREPINEPHRINE CONTENT IN THE CEREBRAL CORTEX OF BALB/C NUDE MICE WITH MULTIPLE PRIMARY MALIGNANT TUMOURS
Authors: Frantsiyants Elena Mikhaylovna , Goroshinskaya Irina Aleksandrovna , Kaplieva Irina Viktorovna , Pogorelova Yuliya Aleksandrovna , Trepitaki Lidiya Konstantinovna , Nemashkalova Lyudmila Anatol'evna
Published: April 2024

The increase in patients with multiple primary malignant tumors (MPMT) determines the need to study their pathogenesis. An important role in the functioning of brain neurons belongs to norepinephrine (NA) and dopamine (DA), which can contribute to tumor development in immunodeficient mice of both sexes.
The purpose of our work was a comparative analysis of dopamine and norepinephrine content in the cerebral cortex of immunodeficient mice of both sexes during isolated and combined growth (MPMT model) of experimental tumors.
Materials and Methods. 56 BALB/c Nude mice were divided into 7 groups: 4 groups of females (intact, mice with standard subcutaneous inoculation of B16/F10 melanoma or Lewis lung carcinoma (LLC), mice with MPMT model – subcutaneous injection of a tumor cell suspension); 3 groups of males (the same groups as for females, except LLC). ELISA technique was used to detect NA and DA content.
Results. In the cerebral cortex of intact females, DA level was higher (3.7 times) and NA level was lower (1.8 times) when compared to males. In all types of tumor growth, monoamine level decrease was observed in animals of both sexes. In females, DA decrease was 57.2 % and 65.8 % with isolated B16/F10 melanoma growth and LLC, and with MPMT it reached 70 %. In males, DA decreased significantly only with MPMT – by 37.6 %. NA in females decreased in case of LLC and MPMT by 26.2 % and 28.1 %, respectively. In males, NA decreased with B16/F10 melanoma and MPMT by 53.3 % and 43 % respectively (p<0.0001 in all cases). In females, there was a more than twofold increase in the ratio of stress-implementing NA and stress-limiting DA (NA/DA) levels, while in males there was a decrease in this index. This was consistent with the large tumor sizes (2–3 times larger) in case of MPMT in females.
Conclusion. The results indicate the participation of brain neurotransmitters in the development of multiple primary malignant tumors in BALB/c Nude mice of both sexes and lower stress resistance in females.
L’acquisition de la liaison : enjeux théoriques, premiers résultats, perspectives
Authors: Chevrot Jean-Pierre , Fayol Michel
Published: April 2024

Bien que la liaison chez l’adulte ait été largement décrite et modélisée, on ne sait presque rien de son acquisition, et de la relation entre cette acquisition et les erreurs enfantines de type des nours ou le zarbre. Cet article montre l’intérêt théorique d’une telle étude et présente des données concernant le rattachement lexical des consonnes de liaison, la question de la généralisation syntaxique dans la définition des domaines des liaisons obligatoires ou facultatives, l’intériorisation de probabilités distributionnelles lors de la segmentation des mots. Ces premiers résultats suggèrent qu’une part au moins de l’acquisition de la liaison progresse à travers des mots ou des séquences de mots particuliers, comme s’effectue l’acquisition du lexique.
Cloud and education: transforming teacher training
Authors: Vorona Vita , Shlikhta Ganna , Kucherenko Iryna , Molnar Tetіana , Sakhnenko Anna
Published: April 2024

The article clarifies mandatory approaches, forms, and resources of learning in a cloud-oriented environment; the possibilities of realizing the advantages of the latest technologies in research institutions are revealed; highlighted the peculiarities of the introduction of cloud technologies in the countries of the European Union and the USA. In the process of research, the ways of ensuring the integration of all components of cloud technologies have been identified. With the aim of changes and innovations of all their components, the main integration functions, factors, and principles of cloud technologies are shown in the preparation and retraining of future teachers-practitioners. This work allowed us to conduct a study that contributed to the development, substantiation, and experimental verification of ways of using a cloud-oriented educational setting for the creation of the qualified position of a teacher. As a result of the experimental work, we observe an increase in the level of IC-competence of teachers, which is possible in a cloud-oriented educational and is a necessary condition for the formation of the professional position of a teacher.
Web-based applications in higher education: revolutionising language learning in the digital age
Authors: Opryshko Natalia , Novik Kristina , Smolinska Olesia , Burmakina Nataliia , Aizikova Lidiia
Published: April 2024

This research article aimed to examine the utilisation of web applications in higher education, specifically focusing on their presentation and usage. Methodology: a mixed approach was used in the study. The results showed that by analysing how these applications are used and discussing user perspectives, the study shed light on the interplay between technical functionality and social engagement in information and communication technologies. Students in higher education view educational web applications as supplementary resources, utilising them for tasks such as translation and pronunciation practice. It can be concluded that the active and productive use of educational mobile applications by students in Ukraine has notably increased, particularly in the context of war. The key benefits reported by students included the accessibility and convenience of web-based educational tools. These applications serve as both learning aids and motivational tools, addressing challenges such as remote learning and limited English-language materials. The widespread use of web applications during times of war has proven instrumental in maintaining educational access and quality in Ukraine.
Consistency of quality management contours for the development of industrial enterprises on the basis of target contour planning
Authors: Kolosok Valeriia , Zhovkovska Tatiana , Kravchenko Maryna , Kolosok Eduard , Honchar Liubov
Published: April 2024

To solve the problem of the qualitative development of industrial enterprises, which lies in the inconsistency of the contours of the quality of the development of the scientific task. The article proposes a methodical approach to the planning of the consistency of the contours of the quality management of the development of industrial enterprises based on the planning of the target contour based on the three-level system model and the means of multifactor modeling, the use of which will allow the management of the industrial enterprise to monitor the state of achievement/failure to achieve the planned development goals and timely identify the cause of this phenomenon during the normal process of management coordination, destabilization and recovery.
As a result of modeling and simulation experiments, a bank of levels of operations for various purposes and source data is obtained. The obtained sets of action sequences can be used as "road maps" in case of a real critical situation.
The proposed approach can be used to develop options for future plans for qualitative development of the enterprise by setting a target situation for a certain future moment in time and finding a sequence of intermediate situations of qualitative development of the enterprise, which leads to setting a goal.
Alternative forms of resolution of labor disputes
Authors: Ustinova-Boichenko Hanna M. , Skriabin Oleksii M. , Fatah Anna Abdel , Yunatskyi Marian O. , Yamkovyi Vladyslav I.
Published: April 2024

The purpose of the article is to identify effective alternative forms of labour dispute resolution based on the analysis of theoretical information and practical experience of their application in the modern world and the possibility of their use in Ukraine. The methodological basis of the work is the methods of analysis and synthesis, comparative law, logical and legal, abstract and logical methods, and the method of generalisation. The author identifies the features and advantages of using the main alternative forms of labour dispute resolution: conciliation, direct negotiations, mediation, arbitration, and mediation. The author examines the international experience of using alternative forms of labour dispute resolution (France, Bulgaria, Poland, and the United Kingdom). The reasons for the low prevalence of the use of alternative forms of labour dispute resolution in Ukraine are: lack of legislative regulation or gaps in it; low level of public awareness; lack of qualified specialists (arbitrators, mediators). The author identifies the appropriate measures for the effective implementation of alternative forms of labour dispute resolution in Ukraine, which will reduce the burden on the judicial system, and resolve labour conflicts more quickly, efficiently, and with lower material costs.
Advancements in the Improvement of Optical Outcoupling Efficiency for Perovskite LEDs
Authors: Liu Chenrun , Li Bobo , Qiu Mingxia
Published: April 2024

In the past 10 years, the development of perovskite light-emitting diodes (PeLEDs) was fast. Due to the excellent properties of high brightness and color purity, multiple color emission, and cost-effective fabrication technology, PeLEDs have been very promising in semiconductor lighting and display applications. In an effort to achieve high-efficient PeLED devices, researchers have devoted themselves to explore and optimize the emitted materials and device structures. Among various research approaches, raising the optical outcoupling efficiency (

η
out

) of PeLED through light management strategies is very important for further promoting device performances, which is due to that approximately 80% of the photons generated internally are captured or worn out in different optical modes in the device. In this review, the latest researches on optical outcoupling regulations in PeLED are outlined, which mainly focus on photophysical properties and implementation methods. As the key part of this review, implementation strategies are classified into the optimization of characteristics of functional materials (refractive index, film thickness, anisotropy, and photon recovery) and adjustment of device architecture (patterned nanostructures, photonic crystals, metal nanostructures, and external couplers). Additionally, a prospect of the future directions and development trend for this research field is presented in order to achieve ultra-efficient PeLED and future commercial applications.
Submesoscale Dynamic Processes in the South China Sea
Authors: Zhang Zhiwei
Published: April 2024

The South China Sea (SCS) is the largest marginal sea in the northwestern Pacific, and it is known for its complex multiscale dynamic processes, including basin-scale circulations, mesoscale eddies, submesoscale processes (submesoscales), and small-scale internal gravity waves. Compared with dynamic processes of other scales, submesoscales are a relatively new dynamic concept; they have gained rapidly increasing attention in recent decades due to their uniquely important roles in oceanic dynamics and biogeochemistry. Considerable progress on submesoscales has been achieved by the SCS regional oceanography community due to improvements in observation and simulation capabilities in the past decade. This paper comprehensively reviews recent research advances on the dynamic aspects of submesoscales in the SCS, including submesoscale resolving/permitting observations and simulations; the general characteristics, spatiotemporal variations, and generation mechanisms of submesoscales; and the roles of submesoscales in energy cascade and vertical tracer transport and the associated parameterizations. The most important advances are as follows: (a) Novel submesoscale observations have been made in the SCS, such as through submesoscale and mesoscale nested mooring arrays. (b) Findings have shown that the spatiotemporal characteristics and generation mechanisms of submesoscales in the SCS are regionally dependent. (c) A generation mechanism called mixed transitional layer instability (MTI) was proposed, and its strength is significantly modulated by strain-induced frontogenesis. (d) A new parameterization of submesoscale vertical buoyancy flux was developed based on the mechanism of MTI modulated by frontogenesis. In addition to reviewing recent advances in this field, this paper presents research prospects on SCS submesoscales.
Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment
Authors: Li Lei , He Shouhua , Liao Boyi , Wang Manchun , Lin Huimin , Hu Ben , Lan Xinyue , Shu Zhilin , Zhang Chao , Yu Meng , Zou Zhaowei
Published: April 2024

The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments. The antibacterial or tumor microenvironment (TME)-modulating approaches have been shown to markedly improve antitumor efficacy, strategies focused on normalizing the microbial environment are rarely reported. Here, we reported the development of an orally administered inulin-based hydrogel with colon-targeting and retention effects, containing hollow MnO
2
nanocarrier loaded with the chemotherapeutic drug Oxa (Oxa@HMI). On the one hand, beneficial bacteria in the colon specifically metabolized Oxa@HMI, resulting in the degradation of inulin and the generation of short-chain fatty acids (SCFAs). These SCFAs play a crucial role in modulating microbiota and stimulating immune responses. On the other hand, the hydrogel matrix underwent colon microbiota-specific degradation, enabling the targeted release of Oxa and production of reactive oxygen species in the acidic TME. In this study, we have established, for the first time, a microbiota-targeted drug delivery system Oxa@HMI that exhibited high efficiency in colorectal cancer targeting and colon retention. Oxa@HMI promoted chemotherapy efficiency and activated antitumor immune responses by intervening in the microbial environment within the tumor tissue, providing a crucial clinical approach for the treatment of colorectal cancer that susceptible to microbial invasion.
An Active Multi-Beam Antenna Design Method and Its Application for the Future 6G Satellite Network
Authors: Tao Xiao , Ding Wei , Wang Shuo , Zhang Xingang , Cui Wanzhao , Cui Qinglong
Published: April 2024

The active multi-beam antenna can be widely used in the 6G integrated satellite network project, the national satellite Internet project, and other major satellite projects. It determines the key performance indicators of the satellite such as the service coverage area and the communication capacity of all the beams in the forward link and the return link. The active multi-beam antenna is the core technology of satellite payload and has been developed rapidly in recent years. Based on the antenna performance requirements such as the number of giant-scale beams, super-large coverage area, high gain, and high carrier-to-interference ratio (C/I), this paper proposes a new active multi-beam antenna design method, which integrates the multi-objective coordination and multi-feed amplitude and phase weighted optimization algorithms. A balanced optimal solution that meets the performance requirements can be obtained by constraining each other with different objective functions. In the optimization process, the surrogate model of convolutional autoencoder based on artificial intelligence technology is proposed for multi-objective optimization solution, which efficiently completes the search of optimal beam excitation coefficients. This paper takes the demand for very-high-throughput communication satellites serving the Asia-Pacific region as an example and applies the design method to the multi-beam antenna design of the satellite. The simulation verification of the antenna is completed, achieving good performance of 976 beams. All results meet the performance requirements, supporting the implementation of 1 Tbps communication capacity for the entire satellite, and verifying the correctness of the design method.
Noncooperative Target Finite-Time Surrounding Control of Spacecraft Formation
Authors: Zhou Lifan , Guo Yanning , Zhang Yu , Huang Panxing , Wang Pengyu
Published: April 2024

This paper proposes a novel distributed control method for surrounding a noncooperative target that has maneuverability by spacecraft formation. A relative orbit error dynamic model between the target and the formation is established dependent on a reference spacecraft under the 2-body assumption. To estimate and compensate for the target’s control input rapidly, a novel finite-time extended state observer is developed. It is stable in the sense of fast finite-time uniformly ultimately bounded stability. A fast terminal sliding mode controller is proposed for finite-time convergence of the system. Simulation examples are implemented to show the effectiveness of proposed algorithm.
Evaluación de la eficacia de pbserum Extreme Firmness en la firmeza y elasticidad de la piel
Authors: López Berroa Jorge , Arenas Escribano Daniel , Beltrán Arredondo Beatriz , Reyes Norma , López Gehrke Ingrid , Castelanich Desirée
Published: April 2024

Introduction. Loss of firmness and elasticity of the skin is a complex phenomenon involving changes in the dermis, epidermis; and is a distinctive feature of skin aging. Peelings with recombinant enzymes may constitute an effective tool to improve the signs mentioned above because those enzymes combine keratinase PB333, collagenase PB220, DMAE, vitamin C, and hyaluronic acid. Objective. A study was carried out to evaluate the efficacy and tolerability of the pbserum Extreme Firmness Professional product in subjects between 24 and 70 years old to measure the firmness and elasticity of the skin before and after continued use of the product. Material and Methods. Following the instructions, participants applied the product containing PB333 keratinase, PB220 collagenase, DMAE, vitamin C, and hyaluronic acid weekly and avoided using other skin care products in the test area. The firmness and elasticity of the skin were evaluated using the Cutometer® dual MPA 580, the organoleptic properties and the result of the treatment, as well as adverse events and dermatological reactions. Results. The study's results showed that after 28 days of use, skin elasticity improved by an average of 11 % compared to baseline, which was statistically significant. Additionally, 96 % of the subjects were satisfied with the results of the product on their skin, with no reports of adverse events. Discussion. Our findings prove, in a statistically significant way, an improvement in the skin's elasticity, hydration, and softness in the subjects who used the product compared to the control group. Conclusions. The study concluded that combining recombinant enzymes of keratinase PB333, collagenase PB220, DMAE, vitamin C, and hyaluronic acid effectively improves skin elasticity in people with sagging skin.
Sustainability in agricultural production and natural resource management T-I Biotechnology and Agricultural Sciences
Authors:   Universidad Politécnica de Francisco I. Madero, AGUILAR-ARTEAGA, Karina
Published: April 2024

This compendium of research papers is a glimpse of the participants that are projected in the handbook on Sustainability in Agricultural Production and Natural Resource Management. The following pages show the results of projects, research and collective efforts presented at the 1 st Inter-University Congress "Sustainability in Agricultural Production and Natural Resource Management and 2nd Inter-University Symposium. Researchers from different institutions of the country share with students, researchers, producers and society in general contents, which with hard dedication, are directed towards the tireless search for knowledge in the field of science. Each of the disciplines addressed in this handbook within the framework of Aquaculture, Animal Production, Sustainable Agriculture, Pest Management and Sericulture represent a testimony of each author's commitment to the understanding of the various topics covered.