bluuebunny/crossref_metadata_2025 huggingface dataset:
An observational study on the effect of stent microbial culture status on double J stent associated lower urinary tract symptoms
Authors: Rassol Mustaq , Praveen A. P. S. Guru , Shaik Jamal , Laxmi Ramesh M. , Vedamurthy Reddy P.
Published: December 2024

Background: The double-J ureteral stent had been widely applied during the endourologic surgery to relieve or prevent ureteral obstruction. Stent-related morbidities, such as lower urinary tract symptoms (LUTS), stent-related body pain and hematuria, are bothersome and might have a negative impact on quality of life (QoL) and sexual performance for both genders. The prevalence of LUTS after double DJ stenting is 50%-70%. The prevalence hence is significant and geographic variance might exist. This makes this issue an important health problem and indirectly serves as a scale for quality of healthcare delivery to the public. This study aimed to study the effect of stent microbial culture status on double j stent associated lower urinary tract symptoms performed at Narayana Hospitals, Nellore.
Methods: An observational study was conducted in the Department of Urology, Narayana Medical College & Hospitals, Nellore for 18 months from June 2021 to November 2022. A convenient sample of 45 were selected among the patients who underwent DJ stenting and presenting with LUTS to the outpatient department.
Results: The sensitivity of urine culture was 29.27%. The specificity and PPV are 100%. The NPV was 12.12% with diagnostic accuracy was 35.56%. The age and symptom score-IPSS were correlated and the r value was -0.03, QOL and Age were correlated with the r value was 0.004.
Conclusions: Urine culture was positive among 26.66% and stent culture in 84% of the stents. Urine culture is highly specific in identifying the stent culture status.
Comparing dominant hand grip strength between housewives and female bank clerks in Ujjain city: an observational study
Authors: Mishra Ruchi , Bijlwan Aanchal , Bajpai Sanket , Jaiswal Ashish , Sethiya Deepa , Gidwani Laxman , Gidwani Mayuri , Jain Sakshi , Bhawar Nandita
Published: December 2024

Background: The human hand, comprising complex musculoskeletal structures including major joints and numerous muscles, plays a crucial role in daily activities. Handgrip strength (HGS) is a key indicator of muscle strength and overall physical fitness. Factors such as posture, age, and physical activity influence HGS. This study aims to compare HGS between housewives and female bank clerks in Ujjain City, given their distinct daily physical activities.
Method: This observational study was conducted over two months in Ujjain, involving 30 women aged 25-35 years, divided into two groups: housewives (n=15) and bank clerks (n=15). Participants were selected through purposive sampling and provided written informed consent. Exclusion criteria included musculoskeletal or neurological deficits, pregnancy, unwillingness to participate, and metabolic disorders.
Results: The mean age of housewives was 28.60 years, and for bank clerks, it was 27.60 years. Housewives demonstrated significantly higher HGS across all three readings compared to bank clerks. The first reading showed housewives with a mean strength score of 15.80 kg and bank clerks with 10.40 kg (p=0.004). The second reading showed mean scores of 11.60 kg for housewives and 7.27 kg for bank clerks (p<0.001). The third reading recorded 8.93 kg for housewives and 5.53 kg for bank clerks (p=0.004).
Conclusion: The study reveals that housewives exhibit higher HGS compared to female bank clerks, likely due to the more physically demanding nature of household tasks. These findings align with previous research indicating that physical activity, including domestic chores, positively impacts muscle strength.
Effectiveness and safety in behavioural and pharmacological interventions in patients of overactive bladder in real-world settings in India
Authors: Wagholikar Hrishikesh , Sharma Akhilesh , Mayabhate Mayur , Jaju Tejashri
Published: December 2024

Background: Overactive bladder (OAB) is a urinary bladder condition causing bladder dysfunction. OAB commonly presents the symptoms of nocturia, incontinence, increased urinary frequency, and urinary urgency with a prevalence of 15.5 % among the Indian population.
Methods: This retrospective observational study assessed the efficacy and safety of combined behavioral and pharmacotherapy in managing OAB in the elderly adult population. Data was collected from digital and paper-based medical records of patients aged 40 years or older. Enrolled patients reported symptoms of OAB for at least 3 months. Efficacy and safety outcomes were assessed using overactive bladder symptom score (OABSS) measured at baseline and after an 8-week follow-up period.
Results: The mean OABSS reduced from 12.39±2.4 at baseline to 8.06±3.46 at 8 weeks post-intervention. A mean difference of 4.33 points (p<0.0001) was observed in OABSS scores between baseline and the 8-week follow-up. During the follow-up, no adverse events were observed.
Conclusions: A mean reduction of 4.33 points in OABSS scores was observed between baseline and the 8-week follow-up, showing a significant decrease in symptom severity with combined behavioral and pharmacological therapy. To assess the long-term efficacy and safety of combined behavioral and pharmacological interventions in OAB patients, studies with large sample sizes are required. This will provide a better understanding to healthcare professionals to optimize OAB management and overcome side effects seen with conventional medications.
Study of glucose specimen integrity in various blood collection tubes over a period of 24 hours
Authors: Warade Jayesh Prabhakar
Published: December 2024

Background: Blood glucose testing is performed to diagnose and monitor conditions such as diabetes mellitus and gestational diabetes in pregnant women. Accurate measurement of plasma glucose concentration is an important component. Here, we have compared the glucose estimation in specimen collected in various collection tubes.
Methods: The samples were stored at 2-4°C temperature and at 0, 4, 12 and 24 hrs aliquots were taken and were processed. Plasma glucose was determined using the glucose oxidase enzymatic methods on the Beckman coulter AU700. All the results at 0 hour were compared with results at 4 hours, 12 hours and 24 hours. Also results of fluoride tubes were compared with results of EDTA, heparin and plane tubes.
Results: We have found no significant difference between results of glucose estimation obtained using samples collected in serum tubes, EDTA tubes, fluoride tube and lithium heparin tube even after 24 hours after separation of serum/plasma.
Conclusions: From this study we have concluded that blood samples collected in plane serum tube, fluoride tubes, EDTA tubes and heparin tubes produce similar results for estimation of glucose if the collected samples are centrifuged immediately after collection for separation of plasma and serum.
Seroprevalence of rubella in female healthcare workers in a tertiary care hospital
Authors: Mishra Jyotsana , Samant S. A.
Published: December 2024

Background: The rubella virus is a member of the genus Rubivirus and causes Rubella infection which is a mild disease characterized by a rash. When rubella virus infects susceptible women early in pregnancy, it may be transmitted to the foetus and may cause birth defects known as the congenital rubella syndrome (CRS). In the healthcare setup the female healthcare workers are    exposed to various infections and have more chances of acquiring Rubella infections. Hence, the healthcare workers of premarital age need to be assessed for their immune status with respect to rubella IgG antibodies. Therefore, this study was carried out to evaluate seroprevalence of Rubella IgG.
Methods: This was a cross-sectional and comparative study conducted in the Department of Microbiology, MGM Medical College and Hospital, Kamothe, Navi Mumbai. Female healthcare workers in the age group 18-30 years were included in the study. The specific IgG antibody titre was evaluated by commercially available ELISA.
Results: Among the total participants (172), 20 were seronegative and 152 were seropositive. Of the total seronegative participants, 2 were vaccinated and none of them had history of past Rubella infection. The maximum seronegative participants were from the age group 18-22 and none from 26-30 age group. The prevalence of Rubella IgG antibodies was found to be 88.38%.
Conclusions: The seronegative healthcare workers need to take precautions and due to the gaps in vaccination coverage, Rubella vaccination should be provided to young healthcare workers to prevent potential outbreak.
Impact of gender, body mass index and educational background on orthorexic tendency in undergraduate students of North India
Authors: Singh Mohita , Sethi Jyoti , Goel Vishal , Kaushik Navneet K.
Published: December 2024

Background: Orthorexia nervosa (ON) is a recently identified eating behaviour disorder characterized by “obsession for healthy eating”. Such behaviour may negatively impact one’s physical and psychosocial health. The present study was designed to evaluate the impact of gender, body mass index (BMI) and educational background on orthorexic tendency of undergraduate students in North India.
Methods: This analytical, cross-sectional study was carried out at Kalpana Chawla Government Medical College (KCGMC), Karnal, Haryana, India on young, healthy students enrolled in different undergraduate courses (medicine, science and arts) at colleges in Karnal district. Risk of orthorexia was assessed using ORTO-15 questionnaire. Subjects who scored below 40 were classified as having ON. Logistic regression analysis was done to examine the relationship between ON and socio-demographic variables.
Results: Study sample comprising of 448 students, of which 273 (61%) were females and 175 (39%) males, had an average age of 19.25 years. Multivariate logistic regression analysis showed that BMI had a significant impact on orthorexic tendency (p=0.024). Students within the normal BMI range were twice (OR=2.0; 95% CI: 1.24-3.24) more likely to have ON than their underweight counterparts. However, no significant relationship was found between gender and ON. With respect to educational background, medical students differed significantly (p=0.001) in their ORTO-15 scores to science students. Arts and science students scores were comparable.
Conclusions: This study suggests that socio-demographic variables might influence orthorexic tendency in student populations. Rising prevalence of this eating disorder necessitates more research to gain a better understanding of its magnitude and etiology.
Risk factors for cervical cancer among women reporting government tertiary care hospitals in Chennai, Tamil Nadu, Southern India: a cross-sectional study
Authors: Sundar Jasmine S. , Srijayanth Parameswari , Karthikeyan P. R. , A. S. Hemapriya , S. Valarmathi , S. Kalpana , A. Arul Paul , Narayanasamy  , G. Srinivas
Published: December 2024

Background: Cervical cancer is widely recognized as a disease characterized by significant disparities, with marked differences in both incidence and mortality rates observed between low and middle-income countries (LMICs) and high-income countries. In India, the disease poses a substantial burden, leading to one death every 8 minutes. India's contribution to global cervical cancer statistics is substantial, with 21% of new cases and 23% of deaths worldwide, surpassing previously leading nations like China. Within Tamil Nadu, it ranks as the second most prevalent cancer among women. This study seeks to comprehensively explore these disparities and identify associated risk factors among women undergoing treatment for cervical cancer at tertiary hospitals in Chennai.
Methods: Participants (n=41) were recruited from October 2021 to May 2022 from five specialized oncology centers. Data on socio-demographic characteristics and medical history, were collected through face-to-face interviews.
Results: The study participants had a mean age of 54±8.26 years, with a majority from Chennai (44%) and Northern Tamil Nadu (36.5%). Common socio-demographic features included low educational attainment (46% with no formal education), rural residence (56%), and modest income levels. Significant risk factors identified included multiparity (Crude’s OR 33.7), family history of cancer (Crude’s OR 22.5), and advancing age.
Conclusions: Cervical carcinoma presents a substantial health burden among women in Chennai. This study identifies critical socio-demographic factors, including age, family history, and parity, as significant contributors to cervical cancer risk. The findings underscore the necessity for targeted public health interventions to enhance awareness and implement effective preventive strategies.
Effectiveness of single shot spinal analgesia with 0.2% ropivacaine in comparison to 0.2% levobupivacaine for labour analgesia
Authors: Kour Gunmeet , Sharma Shivani , Singh Gurbir
Published: December 2024

Background: Labour pain results in a maternal stress response that is not beneficial for the fetus or mother. Spinal analgesia may be a valuable alternative for relieving labour pain. Ropivacaine and levobupivacaine are the drugs commonly used in spinal analgesia. Objectives were to study the efficacy of single-shot spinal analgesia in labour regarding the onset, quality and duration of analgesia, motor blockade, and labour outcome by either ropivacaine or levobupivacaine.
Methods: A prospective observational study conducted in SKIMS, Srinagar which included 60 pregnant women who had received labour analgesia. The patients were divided into two groups. In group I, patients received 1 ml of heavy ropivacaine (0.5%) and in group II patients received 1 ml of heavy levobupivacaine (0.5%). Parameters recorded and assessed were the time of onset of analgesia, duration of epidural analgesia, duration of the first and second and total duration of labour, mode of delivery, fetal heart rate, APGAR scores of the newborn, patient complaints after spinal anaesthesia and mean arterial pressure (MAP), heart rate, visual analogue pain scale (VAS) of the subjects.
Results: The two groups showed no statistical difference with respect to different parameters like age, weight, height, gestational age, body mass index (BMI) and cervical dilation before the block. There was statistically significant difference with respect to the time of onset and duration of analgesia, in two groups. No significant difference was seen, in terms of VAS scores across different time periods.
Conclusions: There was comparable efficacy in terms of analgesic characteristics in both the groups, but levobupivacaine has a longer duration of analgesia, which is helpful for the effective functioning of labour and patient’s satisfaction.
Study of antepartum haemorrhage and its maternal and perinatal outcome in tertiary care hospital
Authors: Sharma Shuchi , Das Jayita , Bhardwaj Suraj
Published: December 2024

Background: Obstetric hemorrhage is a worldwide leading cause of maternal morbidity and mortality. Antepartum hemorrhage includes placental abruption, placenta praevia, placenta accreta spectrum and other undetermined causes.
Methods: A retrospective observational study was conducted in the Department of Obstetrics and Gynaecology, Shri Lal Bahadur Shastri medical college Mandi, Himachal Pradesh for period of two and half years from 1st January 2022 to 30th June 2024. Clinical data of the patients presenting with antepartum haemorrhage was obtained from the delivery records and analysed.
Results: Only 105 (1.02%) out of 10,206 pregnant women in the study period had antepartum hemorrhage. Out of 105 cases, 31 (29.5%) had abruption placenta, 70 (66.6%) had placenta praevia and 4 (3.8%) had other undetermined causes. The most common age group was 26-30 years and the majority were multiparous. Anemia was the most common complication in placental abruption and placenta praevia. NICU admissions were 25.8% in placental abruption and 20% in placenta praevia.
Conclusions: The maternal and perinatal outcome has improved with decline in the number of high-parity women and rise in the availability of antenatal care, sonography facilities and emergency transportation.
Sister Maria Jose's nodule as a presentation of a strangulated umbilical hernia
Authors: González Yazmin G. , Lopez Rodolfo I. , Villarreal Rodrigo , Hernandez Reyger G. , Cruz Alexis
Published: December 2024

The “sister María José” umbilical nodule is a metastatic nodule associated with advanced digestive and gynecological tumors. Skin metastases due to gynecological tumors are not frequent, they only represent 1 to 3% of patients with intra-abdominal cancer and in most cases, they have a poor prognosis. One of the most common types of skin metastasis is the one that occurs at the umbilical level. A case of sister María José nodule is presented as a presentation of a strangulated umbilical hernia in a 67-year-old female patient with a history of ovarian cancer. Exploratory laparotomy was performed with the findings of: tumor in the abdominal wall measuring 10×7×6 cm. The histopathological result is carcinoma with a mucoproducing tubulopapillary pattern. With satisfactory post-surgical evolution and discharged home after 72 hours. Although the initial diagnosis in this patient was a strangulated umbilical hernia due to the clinical presentation and the ultrasound report, we were able to conclude that the definitive diagnosis was “sister María José nodule due to the result of the histopathological report and the history of ovarian cancer 6 years previous.
Pediatric Hashimoto’s thyroiditis: evaluating a rare cause of midline neck swelling
Authors: Ankle N. R. , Rai Akash , Paladugu Tejaswini , Mehta Ayushi , Chaudary Tharun
Published: December 2024

The incidence of Hashimoto’s thyroiditis (HT) in childhood reaches its peak between early to mid-puberty. The AIT’s clinical presentation is optimally assessed with thyroid function, as pediatric patients may exhibit a range of thyroid statuses. A 9-year-old female presented to the ENT OPD with a midline neck swelling, and was diagnosed to have HT. This case report discusses the evaluation and relevant management of this disorder.
Multiple fixed drug eruptions
Authors: Muzaffer Maliha , Jetti Jyothi , Faizan M. Akber Ali
Published: December 2024

Fixed drug eruptions (FDE) are a type of hypersensitivity reaction that occurs in response to certain medications, typically reappearing at the same site when the causative drug is reintroduced. These lesions may present as itchy, red patches, and, less commonly, painful hyperpigmented macules. FDE accounts for a small percentage of all drug reactions and can occur alongside other drug-induced conditions. This case report discusses a 25-year-old female with a history of FDE following the use of norfloxacin and tinidazole for burning micturition and abdominal pain. The patient exhibited well-defined erythematous patches, some associated with previous drug reactions. Discontinuation of the offending drugs and appropriate treatment led to the resolution of her FDE without the appearance of new lesions. Such cases emphasize the importance of early diagnosis and management of FDE in patients with a history of drug-induced skin reactions.
Adult-onset still’s disease: a case report and a comprehensive review
Authors: Mathews Aswathy , Prazad Amal , Neville Brandon
Published: December 2024

Adult-onset still disease (AOSD) is a rare inflammatory disorder affecting young adults, especially women, characterized by fever, arthralgia, skin rash, hyperleukocytosis and increased ferritin levels. It can be monocyclic, polycyclic, or chronic, with chronic cases primarily involving the joints. Ferritin, a protein that stores iron in the body, can be significantly elevated in AOSD due to systemic inflammation and the body’s response to it. Treatment typically includes corticosteroids, methotrexate, and biological therapy. Recent treatments like anakinra, tocilizumab, and TNFα-blockers have shown promise. This case report details a 26-year-old woman with a one-month history of fever, arthralgia, and weight loss. She was diagnosed with a new onset AOSD, based on elevated ferritin, liver enzymes, IL-6, and IL-18 levels. Her symptoms improved with systemic corticosteroid therapy, and she was discharged with oral steroids, NSAIDS and regular follow-ups.
Pediatric anti N-methyl-D-aspartate receptor encephalitis: a case report
Authors: Pokalkar Apeksha , Pokalkar Dhairyawan
Published: December 2024

Anti-N-methyl-D-aspartate receptor encephalitis (NMDARe) is a form of autoimmune encephalitis commonly associated internal malignancy. In this report, we present the case of a 6 years girl with acute onset of left partial seizures rapidly progressed to status epilepticus. The patient had recurrent generalized convulsions requiring multiple admissions. She had dominant neuropsychiatric manifestations, polymorphic seizures, agglomeration of movement disorders and cognitive decline. She did not respond to intravenous steroids and immunoglobulins. She responded to rituximab. She was on maintained on azathioprine for eight months and stopped. Presently she is on two anti-epileptic agents and seizure free. She returned back to school with reasonably good scholastic performance. Early detection, immunomodulation and regular follow up gives good long-term outcomes.
A rare case of retroperitoneal tumor diagnosed as adrenal ancient schwannoma
Authors: Lalithya  , Jadhav Kiran P. , Beedkar Anant N.
Published: December 2024

Retroperitoneal ancient schwannoma is a rare condition. Schwannomas are mostly seen arising from head and neck, flexor aspects of extremities, with an incidence 0.7–2.7%. Other sites of schwannoma are rare with few recorded cases. Retroperitoneal schwannomas (RPS) are relatively rare and constitute only 3% of all schwannomas and 4% of retroperitoneal tumours. Diagnosis is mostly made by histopathology and immunohistochemistry (IHC). Here we report a case of 60-year female with retroperitoneal ancient schwannoma, who presented with chronic abdominal pain.
Cannabis use in older adults-comprehensive literature review
Authors: Mushtaq Raheel , Haque Muhammad Rehan Ul
Published: December 2024

Interest in medical cannabis (MC) use is growing among older adults, driven by its potential for managing chronic conditions such as pain, Parkinson’s disease (PD), and sleep disturbances. However, despite increasing usage, evidence supporting its efficacy remains inconclusive, particularly regarding its effects on mental health, cognition, and quality of life. While MC may offer benefits, such as pain relief and anxiety management, the pharmacokinetic and pharmacodynamic changes associated with aging present unique challenges, including drug interactions and increased vulnerability to adverse effects. Additionally, older adults face an elevated risk of cannabis hazardous or harmful use, influenced by factors like chronic health conditions, cognitive decline, and polypharmacy. A literature search following SANRA guidelines and using PubMed and Google scholar from 1980 to 2024 was conducted, focusing on studies involving older adults and cannabis use. The consequences of cannabis use in this population may include cognitive impairment, cardiovascular issues, and increased risk of falls. This review of literature examines the trends in cannabis use among older adults, the potential benefits and risks, and the need for cautious management and screening to minimize harm. Educating healthcare providers and older adults on the risks of cannabis use and the importance of monitoring is essential. Further research is needed to explore the long-term effects and safety of cannabis in older adults to guide clinical practice.
The current treatment strategies for autoimmune diseases, including immunosuppressive drugs, biologics and emerging immunotherapies like CAR-T cell therapy
Authors: Bandyopadhyay Syamasis
Published: December 2024

This review explores the evolving strategies in autoimmune disease (AID) management, focusing on the limitations of traditional therapies and the potential of emerging treatments. Traditional treatments, including corticosteroids, NSAIDs and DMARDs, are effective but often fail to restore immune tolerance and come with significant side effects. Emerging therapies, such as Janus kinase (JAK) inhibitors and sphingosine-1-phosphate (S1P) receptor modulators, offer targeted approaches by disrupting specific inflammatory pathways. Chimeric Antigen Receptor–T Cell (CAR-T) therapy, originally developed for cancer, is being investigated for AIDs, showing promise in targeting and eliminating autoreactive immune cells. Despite their benefits, these advanced therapies face challenges such as high costs and complex administration. This explored the role of biosimilars, like Exemptia, a biosimilar of Adalimumab, in addressing these challenges. By providing a cost-effective alternative without compromising efficacy or safety, biosimilars expand access to effective biologic therapies for AID management.
Physical therapists’ knowledge, attitudes, and practices in cardiovascular assessment: a brief review
Authors: Sheetal  , Sikka Gitanjali
Published: December 2024

This comprehensive review paper investigates current practices, attitudes, and knowledge related to cardiovascular risk and blood pressure monitoring in physical therapy settings. A thorough search strategy was employed for the review, covering key databases like PubMed and Google Scholar up to march 2024. This approach ensured comprehensive retrieval of studies that cover a range of topics related to cardiovascular risk assessment, blood pressure management, and the knowledge and practices of physical therapists in these areas. The study concludes that there is a notable gap in the knowledge and practice of blood pressure (BP) and heart rate (HR) assessment among physical therapists. There is need to address knowledge deficits of physical therapists regarding screening of cardiovascular parameters. Also, revision of clinical policies could enhance the implementation of assessment of these parameters in regular clinical practises and ultimately improve patient outcomes.
Unveiling the silent threat-understanding hypertension knowledge and perception among adults: review article
Authors: Muskaan  , Sikka Gitanjali , Shaveta
Published: December 2024

Hypertension is major risk factor for cerebrovascular and cardiovascular diseases. Hypertension, characterized by persistently elevated blood pressure, has emerged as a modern- day epidemic, particularly alarming in developing countries. The classification outlined by the Joint National Committee report offers a framework for understanding its severity, ranging from normal to stage 2 hypertension. Notably, studies in regions like Punjab and Haryana highlight the need for tailored interventions and education of patients about the disease knowledge, its severity, and complications. The increasing global prevalence is which inherently increasing the global disease burden whereas knowledge of this disease and its determinants are poor. To evaluate the level of knowledge and perception about hypertension in population. Moreover, the variations in knowledge and perceptions of hypertension between rural and urban populations have yet to be examined. In order to fill this knowledge gap, the current study understanding perceptions and knowledge of hypertension.
Relationship between the six-minute walk test and the two-chair test in young adults: a brief review
Authors: Bhana Amandeep , Sikka Gitanjali
Published: December 2024

As a useful submaximal exercise test for determining functional capacity in cardio-respiratory disorders, the six-minute walk test (6MWT) has gained recognition. But its practical limitations—such as the requirement for a 30-meter corridor and time constraints—present difficulties, particularly for people with restricted mobility. As a quick and effective substitute, the Two Chair Test (2CT) is suggested and assessed in this study. The integrated physiological responses from several exercise-related systems are captured by the sub-maximal character of the 2CT and 6MWT. The 2CT examines post-exercise changes in PR and SpO2 for two minutes in a unique way, while the 6MWT primarily measures distance. The effectiveness and dependability of the 2CT will be verified using standard physiological assessment metrics from cardiopulmonary exercise testing. To summarise, the objective of this research is to thoroughly verify the Two Chair Test, investigate any potential associations with the Six-Minute Walk Test, and evaluate the effects of the test on arterial oxygen saturation and heart rate. The possible consequences encompass providing a more easily available, effective, and targeted substitute for evaluating functional capacity in various healthcare environments.
Comparative evaluation of effect of three different MMP inhibitors on flexural bond strength of resin composite used to restore NCCL - In vitro study
Authors: Jadhav Shrutika , Khode Rajiv , Turkhade Darshan , Burande Arvind , Soni Pritesh , Cirigiri Sushilkumar , Darak Pawan
Published: December 2024

Interface between resin composite and dentin is critical and important for the success of restoration. Application of MMP inhibitor may alter surface characteristic of dentin that improves bond strength of resin composite.

This study evaluated and compared the effect of three different Matrix Metalloproteinase (MMP) inhibitors on flexural bond strength of resin composite restorations; done to restore non carious cervical lesions (NCCL).

: Standardized NCCL was simulated on 41 freshly extracted and selected human premolars. The teeth were randomly assigned into four groups i.e. Group I: Control group (no MMP inhibitor). Group II: Chlorhexidine. Group III: Chitosan and group IV: Proanthocyanidin. NCCL were pretreated with MMP inhibitor of respective group prior to its restoration with nanofilled resin composite. Restorations in each group were finished and polished with an appropriate finishing and polishing kit. The flexural bond strength was evaluated using the universal testing machine. Data were analysed using one-way analysis of variance and Tukey's test.

Among the tested MMP inhibitors; Group II (90.73 Mpa) and Group III (90.17 Mpa) showed highest mean flexural bond strength with insignificant difference ( P = 1.0) between them. Group IV showed higher but insignificantly different (P= 0.768) flexural bond strength to that of group I.

Group II and Group III worked best to increase the flexural bond strength of resin composite indirectly representing its higher MMP inhibition and collagen stabilizing activity than Group IV and Group I.
Nutritional support in critical care patients: Challenges, strategies, and recent advances
Authors: Shetti Akshaya N
Published: December 2024

Nutritional support is a critical component of managing patients in intensive care units (ICUs). Critical illness triggers a hypermetabolic state, leading to significant nutritional demands and muscle wasting. Proper nutritional interventions can positively impact clinical outcomes, reduce the duration of mechanical ventilation, and improve overall recovery. However, delivering adequate nutrition to critically ill patients present several challenges, including the patient's unstable condition, varying metabolic needs, gastrointestinal dysfunction, and difficulties in achieving nutritional goals. Recent advances in understanding the nutritional requirements of ICU patients, the role of early enteral nutrition, and the development of specialized formulas have led to improved patient care. Strategies such as personalized nutrition, immunonutrition, and monitoring tools like indirect calorimetry have become essential components of ICU nutrition management. Additionally, managing critically ill patients with comorbidities, such as sepsis or multi-organ failure, requires tailored approaches to prevent malnutrition and overfeeding.

This review highlights the key challenges associated with nutritional support in critical care, current strategies employed to optimize nutrition, and the recent advances in the field. Evidence-based practices with individualized care, nutritional support can enhance patient recovery, reduce ICU stay, and lower morbidity and mortality rates.
Nutritional benefits of camel milk in autism-A mini-review
Authors: Srivastava Saroj
Published: December 2024

Camels are essential livestock for milk, meat, and transportation, particularly in arid regions.

Camel's milk is a staple diet worldwide due to its nutritional value, including lactoferrin, calcium, vitamins, peptides, zinc, and polyunsaturated fatty acids (PFA). It has therapeutic properties like anti-diabetic, bactericidal, anticarcinogenic, and anti-hypertensive effects. Camel's milk also increases carbohydrate metabolism, curing gastrointestinal disorders due to polyunsaturated fatty acids, vitamins, and anti-inflammatory proteins. Its low fat and cholesterol levels, vitamins, minerals, and insulin content make it a critical source of insulin, potentially helping treat diabetes.

This review article mainly emphasized the maximum nutritional benefit of camel milk consumption by children or adults suffering from autism spectrum disorders (ASD) after going through extensive reviews of published articles.

This article was conducted based on searches in open-source databases like Google Scholar, Embase, DOAJ, PubMed, etc., using specific keywords such as ‘camel milk,’ ‘camel milk benefit,’ ‘camel milk future,’ etc.

Camel's milk has been found beneficial for individuals with autism spectrum disorders in India, but further scientific research is needed to comprehend its nutritional and physiological benefits fully.
Cambalaches ` patafísicos con Rubén Bonet: Un ensayo visual
Authors: Bonet Ruben , Andrade X.
Published: December 2024

Este intercambio expresa fehacientemente la presencia contemporánea de la `Patafísica en las artes visuales, la literatura y la antropología. Dos entidades paródicas de México y España, y de Ecuador y Colombia —la Fundación Adopte a un Escritor y Full Dollar, respectivamente— muestran su fidelidad al espíritu irreverente del College de `Pataphisique (1948 de la era vulgar). Este ensayo expresa, mediante una curaduría de imágenes y diá- logos yuxtapuestos, las posibilidades de lo irracional. Buena falta le hace a la academia, y a su alma tallada en la corrección política, retomar el ímpetu crítico de la parodia y otras estrategias desplazadas so pena de terminar de cavar su propia tumba.
Viabilidad del Stare Decisis en el Arbitraje Nacional ecuatoriano: Navegando entre puntos conciliables
Authors: Almeida Vintimilla Gabriel Eduardo
Published: December 2024

El presente artículo busca encontrar la viabilidad de la doctrina stare decisis hacia una jurisprudencia arbitral para el sistema ecuatoriano. En primer lugar analizará su origen, desarrollo y tratamiento jurídico dentro del Common Law, así como dentro del Civil Law. Posteriormente abordará la naturaleza jurídica del arbitraje en el Ecuador, para determinar la existencia de una posible relación entre la doctrina del stare decisis y el derecho arbitral ecuatoriano, sustentando dicha propuesta sobre puntos conciliables verificables en sistemas arbitrales comparados, y unificando dichos puntos conciliables con las características del sistema arbitral ecuatoriano, evidenciando una clara viabilidad y necesidad de su consideración e incorporación, frente a una incipiente existencia de dicha doctrina en el sistema ecuatoriano de justicia. Finalmente, para completar el presente trabajo, se propondrá una reforma a la Ley de Arbitraje y Mediación, agregando un formato de convenio arbitral susceptible de favorecer la inclusión del stare decisis en el arbitraje ecuatoriano, con características y propiedades que le sean adecuadas y a la medida para su procedencia.
Veinticuatro años de la acción de nulidad de laudos: un análisis empírico
Authors: Andrade Cadena Xavier , Rivadeneira Chacón Gabriela , Arroyo Aguirre Carolina , Fierro Valle Estefanía , González Vallejo Sol
Published: December 2024

Este artículo realiza un análisis cualitativo y cuantitativo de las acciones de nulidad de laudos arbitrales presentadas en Ecuador desde la promulgación de la Ley de Arbitraje y Mediación en el 1997, con el objetivo de contrastar las normas legales con la práctica judicial. Esta aproximación nos ha permitido detectar los aciertos y las falencias de las resoluciones de las cortes provinciales sobre la acción de nulidad.
Una revisión del sistema arbitral desde la jurisprudencia de la Corte Constitucional en los últimos tres años
Authors: Barrazueta Bucaram Lorena
Published: December 2024

Este artículo contiene una sistematización de los pronunciamientos más relevantes que ha emitido la Corte Constitucional en materia de arbitraje doméstico desde febrero de 2019 hasta septiembre de 2022.
Mitorealizm 神实主义 Yana Lianke 阎连科. W kręgu realizmu magicznego, groteskowego i wewnętrznej prawdy o chińskiej rzeczywistości
Authors: Kasarełło Lidia
Published: December 2024

Artykuł jest poświęcony próbie definicji oraz analizie wiązadeł i cech dystynktywnych mitorealizmu – chińskiego konceptu literaturoznawczego zaproponowanego przez Yana Lianke (ur. 1958). Lianke występuje w artykule w podwójnej roli, raz jako twórca wielu wybitnych powieści współczesnych – w tym sześciu przełożonych w latach 2019–2023 na język polski (Sen wioski Ding, Kroniki Eksplozji, Czteroksiąg, Całusy Lenina, Dzień w którym umarło słońce, Sutra serca); dwa – jako autor pogłębionej refleksji na temat odmian realizmu i kazualności w literaturze (książka Faxian xiaoshuo). Rozważania Yan Lianke służą jako punkt wyjścia, a zarazem jako kontekst umożliwiający usytuowanie zjawiska mitorealizmu w historii literatury chińskiej zarówno w dawnej tradycji powieściowej, w opowiadaniach Lu Xuna, jak i przede wszystkim literaturze Nowego Okresu (głównie xungen wenxue i Mo Yana). Analiza sześciu powieści pokazuje, że mitorealizm jest rodzajem wehikułu artystycznego, który pozwala na odsłonięcie wewnętrznej prawdy o absurdalnej i chaotycznej rzeczywistości współczesnych Chin. Ponieważ jest to prawda skrywana przed rozumowym rozpoznaniem „wewnętrznej przyczynowości”, w dalszej części artykułu poszukuje się znajomych modeli i strategii literackich, aby objaśnić złożoność mitorealizm Yana. W tym celu najpierw omawia się podobieństwa i różnice między mitorealizmem i najbardziej zbliżonymi do niego realizmem magicznym i groteskowym, a potem – w części poświęconej para- i metatekstualności oraz strategiom narracyjnym i językowym – przytacza przykłady obecności elementów realizmu magicznego i groteskowego w mitorealistycznej powieści Yana. Interpretacyjne eksplikacje sześciu powieści, bogato ilustrowane przykładami poprzedza obszerny fragment na temat niejednoznaczności i roli autocenzury w omawianej kreacji Yana Lianke, który wykorzystuje aluzję, magię, groteskę, absurd i tryb alegoryczny do uporania się z traumą przeszłości oraz krytyką współczesnej rzeczywistości chińskiej.
Diagnóstico base para el fortalecimiento de las políticas institucionales
Authors: Santamaria Ariza Liliana , Suárez Marín Laura Daniela
Published: December 2024

l presente documento titulado Diagnóstico final para el fortalecimiento de las políticas institucionales de la Universidad Militar Nueva Granada corresponde a la descripción detallada y gráfica de un análisis interno y externo realizado por el equipo conformado para la revisión de las políticas institucionales de la Universidad.

Su desarrollo incorpora como contenido la exposición teórica y de relevancia de un diagnóstico, entendido como un eje central para la construcción de las políticas que se gestan en la institución. De esta manera, a partir de la incorporación de lineamientos macro, se crea una metodología para darle aplicabilidad al diagnóstico a través de un plan estratégico que articula tres fases: fase 1, elaboración del diagnóstico preliminar; fase 2, articulación con los grupos de valor e interés, y fase 3, análisis de la información.

A partir de la primera fase y en aplicación a la técnica revisión-selección análisis, se examinan los siguientes documentos (I) las políticas, normas y documentos rectorales; (II) la matriz de grupos de interés; (III) los instrumentos de medición del ejercicio en términos de análisis de conecto institucional, y (IV) los comentarios del rector al informe de evaluación externa con la finalidad de identificar los puntos de mejora asociados a las políticas institucionales de la Universidad.

De manera continua, la segunda fase evidencia el reconocimiento fáctico de la institución con relación a los grupos de valor y de interés, lo que permite que a través de la interacción y participación de los mismos se articule su perspectiva y se fortalezca la gobernanza institucional. Dentro de los grupos partícipes se encuentran los estudiantes, los egresados, el personal administrativo y el personal docente. A partir de dicha relación se logra construir una percepción más cercana sobre las políticas institucionales y
su alcance.

Finalmente, la tercera fase presenta un análisis detallado de la información que proporciona una visión específica, conjunta e integral acerca de la situación de cada una de las políticas institucionales. De lo anterior se genera una clasificación que permite determinar las políticas vigentes susceptibles de mejoras y aquellas que, sin estar vigentes o formuladas, corresponden a un compromiso institucional. De esta forma, el análisis en mención aborda cada fuente de información a partir de la ausencia y presencia de tres dimensiones: normativa, estructural y pertinencia.

Producto del ejercicio metodológico, el presente diagnóstico identifica las políticas institucionales que deben ser actualizadas o complementadas, unificadas y creadas para el fortalecimiento de la arquitectura institucional de la UMNG.
The effect of mono- and divalent cations on Tetrahymena thermophila telomeric repeat fragment. A photon correlation spectroscopy study.
Authors: Włodarczyk Agnieszka , Patkowski Adam , Grzybowski Przemysław , Dobek Andrzej
Published: December 2024

The structure of the Tetrahymena thermophila telomeric sequence d(TGGGGT)(4) was studied by photon correlation spectroscopy (PCS) in aqueous solution in the presence of NaCl, KCl and SrCl(2). The sample studied was polydisperse in all conditions studied. Translational diffusion coefficients D(T) describing the diffusion modes observed were determined. On the basis of a comparison between the experimental D(T) values with those calculated assuming the bead model, two forms were identified as telomeric quadruplex structures: monomer and tetramer. In the presence of SrCl(2) formation of aggregates was observed, with a size that reached several micrometres. The relative weighted concentrations of the structures observed for different concentrations of a salt and DNA were determined. The results obtained in the presence of monovalent ions were qualitatively similar and could be presented in a coherent plot in which the concentration of salt was expressed by the number of ions per DNA molecule. A large number of ions per DNA molecule favoured tetramer formation while a small number favoured the monomer form. A structural phase transition from the monomer to the tetramer induced by a change in the number of ions per DNA molecule was observed. The main difference between the results for Na(+) and K(+) was a greater effectiveness of the K(+) ions in formation of tetramers. The effect of Sr(2+) ions on the structures formed was different than that of the monovalent ions. The results obtained in the presence of Sr(2+) could not be described as a function of the number of ions per DNA molecule.
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI.
Authors: Zhang Jiayi , Dai Jianliang , Zhao Enpeng , Lin Yun , Zeng Li , Chen Jinzhong , Zheng Huari , Wang Yu , Li Xin , Ying Kang , Xie Yi , Mao Yumin
Published: December 2024

Peptidylarginine deiminase (PAD) catalyzes the post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Human, similar to rodents, has four isoforms of PAD (type I, II, III and IV/V), each of which is distinct in substrate specificity and tissue specific expression. In our large-scale sequencing project, we identified a new human PAD cDNA from a human fetal brain cDNA library. The putative protein encoded by this cDNA is designated hPADVI. Expression analysis of hPADVI showed that it is mainly expressed in adult human ovary and peripheral blood leukocytes. We conclude that hPADVI may be orthologous to mouse ePAD, basing on sequence comparison, chromosome localization and exon-intron structure analysis. PAD-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development. This study describes a new important member of the human PAD family.
Monocytes in children with leukemias and lymphomas -- down-regulation of HLA and costimulatory molecules.
Authors: Łuczyński Włodzimierz , Stasiak-Barmuta Anna , Krawczuk-Rybak Maryna , Szymański Marcin , Malinowska Iwona , Mitura-Lesiuk Małgorzata
Published: December 2024

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.
Sensitivity of Engineering Critical Assessmentof Through-Thickness Axial Flaws on Pressure Equipment
Authors: Hajro Ismar , Tasić Petar Tasić , Softić Almira , Pandžić Adi
Published: December 2024

This paper deals with a sensitivity analysis of engineering critical assessment, using a fracture assessment diagram of through-thickens axial flaws on pressure equipment. Basic option calculations are performed per BS 7910, using engineering fracture mechanics principles, followed by the provision of assessment points. For evaluation purposes, arbitrary design properties of pressure equipment and temperature-dependent materials properties were used. Several through-thickness axial flaw sizes were used for critical assessment. Furthermore, the sensitivity of critical assessment is evaluated by varying stress states and material fracture toughness. Finally, the sensitivity analysis shows how axial flaw growth may become critical, or its acceptability, depending on varying stress states and temperature-dependent material properties, on selected pressure equipment.
Verification of the Impact of the Distance Education Program on the Development of Students' Skills
Authors: Huľová Zlatica , Tokoš Peter , Bolčová Emília
Published: December 2024

The authors present research focusing on the issue of technical education in the context of distance education. It deals with the development of psychomotor skills of students in a vocational subject during distance education. The research aimed to verify the impact of the designed distance education program on developing and enhancing students' skills in the subject of robotics. The sample consisted of 10 students. A pedagogical experiment was used as the research method. The findings show statistically significant changes in the students' skills in the posttest compared to the pretest. It was mirrored in higher values of the skill posttest results. The designed distance education program helped develop students' manual skills. The research results emphasize the importance of personal interaction and support in technical education. The paper was created as a part of the grant project VEGA No. 1/0550/22 Current state, trends, and problems in technical education at the lower and upper secondary education level concerning distance education.