bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Data from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Supplementary Figures and Tables
Figure 6 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

BM-derived CD8+ T cells of nonresponders (FAIL) displayed a suppressed cytotoxic molecular signature at the single-cell level. A, Dot plot representing MSigDB (Hallmark 2020) enrichment analysis of positively enriched pathways in FAIL patients. Enriched pathways with a q-value <0.05 (Benjamini–Hochberg correction) are shown. B, TGF-β signaling score of cluster 2 (CTL_1) and violin plots displaying the expression levels of the top DEGs of cluster 2 (CTL_1), involved in the enrichment of the TGF-β signaling pathway between CR and FAIL. C, TGF-β signaling score of cluster 4 (CTL_2) and violin plots displaying the expression levels of the top DEGs of cluster 4 (CTL_2), involved in the enrichment of the TGF-β signaling pathway between CR and FAIL. D, Comparison of the cytotoxic score of each group, as it is projected onto the respective UMAPs. E, Cytotoxic score of cluster 2 (CTL_1) and violin plots exhibiting the expression levels of the top differentially expressed cytotoxicity-related genes of cluster 2 (CTL_1) between CR and FAIL. F, Cytotoxic score of cluster 4 (CTL_2) and violin plots exhibiting the expression levels of the top differentially expressed cytotoxicity-related genes of cluster 4 (CTL_2) between CR and FAIL.
Figure 3 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Association between the frequency of CD57+CXCR3+CD8+ T cells and outcome in patients with HR-MDS and AML under treatment with AZA. A, Box plots displaying the percentage of the CD57+CXCR3+ cells within CD8+ T cells, assessed by flow cytometry in responders and nonresponders (HR-MDS, n = 12 responders and 9 nonresponders; AML, n = 9 responders and 11 nonresponders; CMML, n = 5 responders and 5 nonresponders). B, After stratification of patients with HR-MDS and AML to responders (n = 12) and nonresponders (n = 19), FlowSOM analysis was performed on BM CD8+ T cells, which generated six metaclusters that are projected onto the viSNE plots. Representative viSNE plots (one for each group) are shown. C, Box plots showing the proportion of all metaclusters, expressed as the frequency within CD8+ T cells. D, Heatmap depicting the expression levels of all T-related markers. E, Kaplan–Meier curves for OS in patients which received AZA treatment, with ≤29% (n = 51) and >29% (n = 26) CD57+CXCR3+ CD8+ T cells before treatment initiation. The survival curves were compared by the log-rank (Mantel–Cox) test, and the P value is shown. The median OS of the ≤29% group was 20.98 months, whereas the median OS of the >29% group was 12.05 months. F, Survival curves for each disease subgroup. Increased (%) CD57+CXCR3+ correlates significantly with worse survival in patients with HR-MDS and AML, whereas no association is observed in patients with CMML. G, Patients with HR-MDS and AML with ≤29% CD57+CXCR3+ exhibited higher response rates. No association between the frequency of CD57+CXCR3+CD8+ T cells and response to therapy was observed in patients with CMML. An unpaired Student t test was used in A. A Mann–Whitney U test was used in D. **, P < 0.01; ***, P < 0.001.
Figure 2 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Identification of a CD8+ subpopulation (CD57+CXCR3+) which distinguishes patients with MDS from patients with AML and CMML. A, Representative viSNE plots, derived from the FlowSOM analysis of BM CD8+ T cells from patients with LR-MDS (n = 12), HR-MDS (n = 15), AML (n = 16), and CMML (n = 5). B, Bar plots displaying the proportion of the metaclusters between the groups, expressed as percentage within CD8+ T cells. C, Heatmap depicting the expression level of the T-related markers between the metaclusters. D, Violin plots showing the expression level of CXCR3 in metacluster 1. E, Representative flow cytometry plots for the identification of the CD57+CXCR3+CD8+ T cell subpopulation in a cohort of patients with LR-MDS (n = 7), HR-MDS (n = 27), AML (n = 20), and CMML (n = 10). F, Percentage of CD57+CXCR3+ cells within CD8+ T cells. Kruskal–Wallis was used in B and D. One-way ANOVA followed by the “two-stage” Benjamini, Krieger, and Yekutieli multiple comparison test was used in F. *, P < 0.05; ***, P < 0.001.
Figure 1 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Untargeted analysis of CD45+ immune cells in patients with MDS, AML, and CMML by CyTOF. A, Multidimensional scale plot depicting the relationship between BM samples of patients with LR-MDS (n = 12), HR-MDS (n = 15), AML (n = 16), and CMML (n = 5). B, Heatmap showing the expression of the markers used for the characterization of each cell cluster. C, UMAP displaying the major immune cell clusters. D, Box charts displaying the frequency of each cell cluster. E, Violin plots showing the expression level of CXCR3 in the CD8 T1, CD8 T2, and CD4 T2 clusters, respectively. Kruskal–Wallis followed by the “two-stage” Benjamini, Krieger, and Yekutieli multiple comparison test was used in D. One-way ANOVA followed by the “two-stage” Benjamini, Krieger, and Yekutieli multiple comparison test was used in E. *, P < 0.05; **, P < 0.01.
Data sheet 2 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
Authors: Tasis Athanasios , Papaioannou Nikos E. , Grigoriou Maria , Paschalidis Nikolaos , Loukogiannaki Catherine , Filia Anastasia , Katsiki Kyriaki , Lamprianidou Eleftheria , Papadopoulos Vasileios , Rimpa Christina Maria , Chatzigeorgiou Antonios , Kourtzelis Ioannis , Gerasimou Petroula , Kyprianou Ioannis , Costeas Paul , Liakopoulos Panagiotis , Liapis Konstantinos , Kolovos Petros , Chavakis Triantafyllos , Alissafi Themis , Kotsianidis Ioannis , Mitroulis Ioannis
Published: December 2024

Data sheet 2
Correlation Between CT Renal Angiography of Live Kidney Donors and Intraoperative Findings: A Cross-sectional Study
Authors: Jaafar Mzhda Sahib , Mohammed Naser Abdullah , Said Shakhawan Hama Amin , Bapir Rawa , Hiwa Dilan S. , Abdalla Berun A. , Kakamad Fahmi H.
Published: December 2024

Introduction
A comprehensive understanding of the renal vascular anatomy variations is paramount to a successful kidney transplant. This reduces vascular injury risks and minimizes ischemia duration, optimizing surgical outcomes. The current study aims to assess the accuracy of renal computed tomography angiography (CTA) findings of live renal donors by comparing them with intraoperative findings.
Methods
This prospective cross-sectional study was conducted between October 2018 and February 2020. It included all healthy donors with two kidneys of normal size, shape, and position who were deemed suitable for nephrectomy. The CTA examinations were performed with the same protocol, which combined the vascular-excretory phase. A specialized radiologist confirmed anatomical findings. The CTA results were compared with intraoperative findings, which were documented by the transplantation team.
Results
The study included 220 patients. The preoperative CTA was highly sensitive and accurate, reaching 99.5% and 98.6%, respectively, for single vessels and 100% sensitivity and accuracy for triple vessels, pelvicalyceal system, and ureter duplication. The sensitivity of CTA for double vessels (vein and artery) was 90% and 92.6%, respectively, while accuracy was 98.6% for both.
Conclusion
CTA can be used to assess renal arteries and veins for potential renal donors with high accuracy. Although the CTA's minor, statistically non-significant discordance with the surgical findings regarding double arteries and veins, no artery or vein was missed on the CTA. Therefore, the sensitivity of CTA can reach 100%.
Geographical distribution of dental caries prevalence and associated factors in young males in Finland 2021: a cross-sectional study
Authors: Laaksonen Elias , Tanner Tarja , Patinen Pertti , Päkkilä Jari , Tjäderhane Leo , Anttonen Vuokko , KämppiA Antti
Published: December 2024

Introduction
Finnish conscripts have proven to be an excellent study group for epidemiological research in oral health in recent decades. The aim of this cross-sectional study was to determine the geographical distribution of dental caries prevalence in young healthy males in Finland at the beginning of the 2020s. Associated dental caries risk factors were of interest as well.
Methods
The data were randomly collected from the eight biggest garrisons in Finland in July of 2021 by ten calibrated dentists. The study population consisted of 2077 male conscripts born between 2000 and 2002. Dental caries was recorded according to the ICDAS system. Wisdom teeth were excluded. Mean DMFT and mean DT values were calculated and geomaps were constructed to visualize the geographical distribution. Generalized linear mixed models with logit link were conducted for the associated risk factors.
Results
The mean DMFT value of all conscripts was 3.29 (SD 3.91), while the mean DT value was 1.19 (SD 2.33). Living in areas with endemic fluoride levels in drinking water ≥0.3 mg/l, decreased the odds for restorative treatment need.
Conclusion
While geographical distribution of dental caries prevalence has remained nearly the same as before, the overall restorative treatment need and treatment history has decreased countrywide.
Treatment duration of adjuvant immune checkpoint inhibitors in hepatocellular carcinoma patients at high risk of recurrence after resection: A prospective, multicentric cohort study
Authors: Su Jia-Yong , Liu Shao-Ping , Xu Xiao-Ling , Ou Jun-Jie , Ye Po-Hua , Zhao Bin-Tong , Chen Jia-Song , Luo Qiu-Mei , Liu Jin-Rong , Tang Fei-Min , Li Jian-Rong , Yang Da-Long , Deng Zhu-Jian , Pan Li-Xin , Li Yao-Jie , Li Le , Qin Zhen-Ming , Liang Xiu-Mei , Ma Yi-Li , Ma Liang , Zhong Jian-Hong
Published: December 2024

Introduction: Adjuvant immune checkpoint inhibitors (ICIs) may improve recurrence-free survival (RFS) in patients with hepatocellular carcinoma (HCC). This study evaluated the effects of adjuvant ICI treatment duration on RFS and overall survival (OS) among patients with HCC at high risk of recurrence.
Methods: The RFS and OS of patients from three centers who received either adjuvant ICI therapy or active surveillance after curative hepatic resection between January 1, 2019 and December 31, 2023 were analyzed. Further analysis was performed to evaluate the effects of ICI treatment duration on RFS and OS.
Results: A total of 1271 patients were included, of whom 1032 (81.2%) received active surveillance and 239 (18.8%) received adjuvant ICI therapy. The median RFS in the adjuvant therapy cohort was 22.6 months (95% CI 18.3–26.9), significantly higher than the RFS of 19.1 months (95% CI 16.4–21.4) in the active surveillance cohort (HR 0.79; 95% CI 0.66–0.95; p = 0.019). The median OS was not reached for either group, but OS tended to be better in the adjuvant therapy cohort than in the active surveillance group (HR 0.72, 95%CI 0.54–0.94; p = 0.010). Similar results were obtained after propensity score matching. Among patients who received adjuvant ICI therapy, those who received it for longer than 6 months had slightly higher RFS (HR 0.66; 95% CI 0.42–1.04; p = 0.071) and OS (HR 0.59; 95% CI 0.30–1.17; p = 0.128) than those who received it for up to 6 months.
Conclusions: Adjuvant ICI therapy significantly improves the prognosis of patients with HCC at high risk of recurrence after curative resection. Six months of adjuvant ICI treatment may be insufficient.
Electric Engine Stand with Trolley
Authors: Dizon Jr Rene C. , Abadam Mark Vincent
Published: December 2024

This study focused on the fabrication of an electric engine stand with trolley. This study aimed to fabricate electric engine stand with trolley and assess its efficiency in terms of safety, dura-bility and functionality. The project followed a systematic approach including planning and designing, gathering all the materials, con-struction, testing, revision and finalization phases. The finish device Electric, Engine Stand with Trolley, demonstrated capabilities such as that the engine stand can lessen the time consumption in assem-bling and disassembling of an engine and it is safe for automotive technician to avoid accidents. The project evaluation revealed High-ly Efficient that the Electric Engine Stand with Trolley fulfilled its purpose of providing safe, durable, and functional equipment that automotive student can use effectively when assemble and disas-semble of engine. In terms of safety, the design incorporates several features aimed at minimizing risks associated with engine handling. The trolley mechanism allows for smooth transportation, reducing the likelihood of accidents during movement. The materials and construction of the Electric Engine Stand with Trolley withstand the rigors of daily use, with a lifespan exceeding industry standards of a Highly Efficient in the level of efficiency. Additionally, its multifunc-tional design accommodates a variety of engine sizes and configura-tions, making it versatile for different automotive tasks. The Electric Engine Stand with Trolley offers notable improvements in efficiency, safety, durability, and functionality, positioning it as an essential tool for modern automotive workshops.
Difficulties in Field Study of Education Students
Authors: Santiago Lilia M.
Published: December 2024

This study aimed to identify the challenges faced by Education students during their Field Study (FS) courses in the second semester of the 2016-2017 academic year. Focusing on three specific FS courses—Field Study 2: “Experiencing the Teaching-Learning Process,” Field Study 5: “Learning Assessment Strategies,” and Field Study 6: “On Becoming a Teacher”—the research utilized a descriptive survey method, incorporating documentary analysis of grading sheets and workbooks. The findings highlighted three primary issues contributing to the difficulties experienced by students: challenges with resource teachers, learner behavior, and self-related issues among the FS students. To address these challenges, participants proposed several solutions, leading to the recommendation that both the Teacher Education Institution (TEI) and the Department of Education (DepEd) revisit their Memorandum of Agreement (MOA) prior to the commencement of Field Study courses, ideally through a formal ceremony.
Assessing The Capability of Disaster Risk Reduction and Management in Marikina City
Authors: Guardiano Hershey Lee A.
Published: December 2024

This study assesses the capability of disaster risk reduction and man-agement (DRRM) in Marikina City, Philippines, aiming to enhance disas-ter resilience through effective implementation of Republic Act 10121 the Philippine Disaster Risk Reduction and Management (DRRM) Act of 2010. The research assesses Marikina City's implementation and chal-lenges across disaster prevention and mitigation, disaster preparedness, disaster response, and disaster recovery and rehabilitation. Utilizing a quantitative methodology, data were collected from Marikina City Disas-ter Risk Reduction and Management Office (MCDRRMO) personnel, ba-rangay officials, and residents to evaluate implementation levels and identify challenges. This research contributes significantly to under-standing local government DRRM capabilities in urban disaster-prone areas. It provides valuable insights for policymakers and practitioners, highlighting effective practices and areas for further improvement. The study found that continuous capacity building, community engagement, and inter-agency collaboration are critical for strengthening Marikina City's resilience. It offers valuable recommendations for local policy-makers and practitioners to address identified challenges and improve DRRM implementation."
Enhancing Organizational Well-being and Employee Health: Strategic and Holistic Approaches for Primary and Allied Healthcare Providers
Authors: Alipio John N. , Cacatian Rona R. , Corpus Roland Azel F. , Ronquillo Christine Angeli M. , Sarmiento Isabelle S. , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

The purpose of this study is to identify and evaluate effective strategies for enhancing organizational well-being and employee health among prima-ry and allied healthcare providers in the Philippines, with a focus on develop-ing holistic approaches that address both physical and mental health needs.Recognizing the value of employee well-being in the healthcare sector, in-stitutions are looking for ways to improve employees’ overall health and well-being and subsequently increase their job satisfaction and productivity.This study will assess the strategies and effectiveness of implementing different health promotion programs among primary and allied healthcare providers in the Philippines across different sectors to enhance employee well-being and contribute to organizational productivity and success. This study will assess different areas of employee well-being, such as stress man-agement, mental health support, physical health promotion, and work-life balance. These programs may include a variety of wellness initiatives, such as fitness classes, mental health awareness seminars, health screenings, stress management workshops, and flu vaccination drives. Organizations may build a supportive work environment that promotes employee satisfac-tion, resilience, and optimal performance by understanding the unique is-sues that healthcare professionals confront and implementing focused inter-ventions and targeted solutions.This study will look for effective techniques that can be adjusted to the specific needs of healthcare institutions in the Philippines. The findings will be useful for politicians, healthcare administrations, and human resource officers looking to improve employee well-being and, as a result, patient care quality.
Impact of E-Government Technologies on Citizen Engagement and Service Delivery: A Case Study of Local Government Units in Caloocan
Authors: Valle Janet S. , Bugayao Zelve Rose , Gutierrez Cristofer , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

The emergence of technology significantly affects the transformation of how the local government and its citizens interact through the utilization of the e-government services platform. This study focuses on the impact of e-government technologies on citizen engagement and service delivery in the Local Government Unit (LGU) of Caloocan City. The results high-light citizens' perspectives on Caloocan's e-government platform, under-scoring concerns, challenges, and suggestions for improvement. Privacy and security rank highly among citizens’ concerns, while language acces-sibility is less of an issue. However, survey data from 250 respondents highlight that 73% expressed satisfaction with the user interface and design of the e-government platform, while 58% trusted the platform's security and privacy measures, though 10% indicated a lack of trust in the system’s data security. To build on this foundation, respondents sug-gest improvements such as better customer support, clearer communica-tion, and training opportunities that could help boost confidence and en-courage active participation. By means of addressing these areas, the platform could be more effectively support the community’s needs, en-hancing trust and fostering a stronger connection between citizens and the local government.
Revisiting Qualification Standards for Local Candidates: Basis for Redefin-ing Social Media Campaign
Authors: Gajudo Maria Bernadeth B. , Cariaga Maria Josefina A. Bartolo , Laroco Joana Marie V. , Suarez Gemma R. , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

The study makes the case that adding social media campaign tactics to the requirements for local office holders will encourage more responsible, knowledgeable, and involved grassroots politics. This study explores the qualification standards for local candidates and how these standards can be redefined in the context of social media campaigns. As digital channels have a greater influence on voter involvement and perception, identifying the criteria that resonate with people becomes critical. The study highlights important characteristics—such as ethics, community involvement, and digital literacy—that distinguish successful local candidates. The study presents a methodology for optimizing campaign messaging and outreach by studying the candidates' successful social media techniques. Finally, the findings aim to help future politicians use social media to increase democratic engagement and develop meaningful ties with voters. This study emphasizes the essential interplay of candidate qualities and internet campaigning in determining electoral results.
Exploring the Influence of Quezon City Scholarships on Advancing Educational Equity and Fostering Social Mobility
Authors: Rowena L Gracilla, , Arreglo Rona-Jean R. , Bago Nackelyn D. , Romero Kristine Joy E. , Ulam Jeffrey A. , Malang Bernandino P. , Malang Jocelyn DS.
Published: December 2024

The study, "Exploring the Influence of Quezon City Scholarships on Advancing Educational Equity and Fostering Social Mobility," examines scholarship programs on advancing educational equity and promoting social mobility among Quezon City's underserved communities. Using a mixed-methods approach, it gathered insights from 174 scholarship recipients through surveys and interviews, focusing on how financial aid affects academic achievement, financial stability, and career opportunities. The findings indicate that these scholarships significantly enhance educational access by lowering financial obstacles and fostering long-term social mobility through improved career prospects and economic stability. Respondents expressed a high level of agreement on the program’s positive influence, with recommendations to cover non-tuition expenses and expand outreach for underserved groups. Ultimately, the research underscores the value of localized scholarship initiatives in fostering both individual development and broader community growth.
A Start-Up Approach to Easy Financing: Solar Energy for Homes and Businesses in Davao City
Authors: Co Zosimo Go , Narsisco Peter G.
Published: December 2024

This study explores innovative financing solutions to expedite the adoption of solar energy systems among households and businesses in Davao City, Philippines. The urgency of addressing climate change and reducing reliance on non-renewable energy sources has amplified the importance of solar energy as a viable alternative. However, the significant initial investment required for solar installations poses a substantial barrier, especially in developing regions such as the Philippines. Existing literature, including IRENA (2014) and subsequent studies by the International Renewable Energy Agency (2021), underscores both the socio-economic benefits of solar energy and the financial challenges in Southeast Asian adoption, mainly due to high costs.
A mixed-methods approach was utilized, integrating quantitative and qualitative research. The quantitative aspect employed a descriptive design, incorporating surveys and interviews with homeowners, business owners, financial institutions, and solar energy providers across three districts in Davao City. The qualitative component involved grounded theory, focusing on in-depth interviews and group discussions to identify barriers and shape tailored solutions. This comprehensive data collection facilitated the development of a locally adapted financing model.
Analysis of findings showed that while there is a strong interest in solar energy, significant obstacles persist, including high upfront costs (cited by 68% of respondents) and limited awareness of financing alternatives (noted by 45%). The proposed start-up model incorporates microfinancing and flexible payment structures, addressing these challenges and incorporating community involvement in financing decisions.
In conclusion, the study demonstrates that an adaptable financing model can drive solar energy adoption in Davao City, fostering sustainable growth and energy self-sufficiency. This framework could be applied in similar contexts across Southeast Asia, promoting more comprehensive renewable energy access and supporting the region's transition to sustainable energy solutions.
A Reacção de Kahn na Lepra
Authors: Silveira Fleury da , Gomes J. M.
Published: December 2024

Se, em muitos casos, o diagnostico entre a syphilis e a lepra é difficil, mai.s difficil ainda se torna reconhecer a simultaneidade das duas infecções. Como é sabido, podemo-nos firmar, para o diagnostico, na anamnese e nos signaes clínicos. A anamnese, em razão da pouca ou nenhuma cultura dos doentes, em geral, não offerece grande animo ao espírito do medico; os signaes clínicos, por seu aspecto proteiforme, não são tambem de molde a lhe levar a certeza. Nestas circumstancias, todos appellaram para os laboratorios, contando com uma reacção digna de confiança.
Notas sobre a fermentação tardia e phenomeno de "caméléonage" com bacillos dysentericos
Authors: Assumpção Lucas de
Published: December 2024

O A. estuda o comportamento de bacillos dysentericos "Shiga", "Y", "Flexner", "Strong", assim como de bacilbs typhicos e paratyphicos A e B em um meio semisolido, com diversos assucares, acompanhando as variações de fermentação na vida saprophytaria desses germens. As experiencias foram feitas nos seguintes assucares: lactose, dextrose, mannita, maltose, saccharose e xylose.
Complement reaction in leprosy. Activation by potassium Iodide
Authors: Gomes J.M. , Antunes P.C. de Azevedo
Published: December 2024

I n 1929, while we studied the effects of the administration of potassium iodide to lepers for the purpose of obtaining a complement reaction (the fat free bacillus of Deycke being used as antigen) we had occasion to note that, almost all cases were activated, so that individuais with a previous negative serum reaction, in spite of the existence of some syrnptoms of leprosy, became positive cases.
Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR
Authors: Starnes Joseph R. , Weiner Jeffrey G. , George-Durrett Kristen , Crum Kimberly , Henderson Christopher C. , Campbell M. Jay , Gambetta Katheryn , Hor Kan N. , Husain Nazia , Li Jennifer S. , Raucci Frank J. , Soriano Brian D. , Spurney Christopher F. , Markham Larry W. , Soslow Jonathan H.
Published: December 2024

BACKGROUND:

Cardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported.

METHODS:

Patients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions were used to evaluate the relationship between diastolic function measures and mortality in the DMD cohort.

RESULTS:

Patients with DMD had significantly smaller stature and ventricular volumes than healthy control patients (
P
<0.001). They had lower baseline LV ejection fraction (
P
<0.001), though most had normal systolic function. When adjusted for age, sex, heart rate, body surface area, and LV end-diastolic volume, patients with DMD had slower peak filling rates (
P
<0.001) and peak ejection rates (
P
<0.001), as well as slower time to peak ventricular ejection rate (
P
=0.011). When adjusted for heart rate, a lower peak ventricular ejection rate (
P
=0.007) and peak filling rate (
P
=0.033), normalized to LV end-diastolic volume, were associated with mortality in patients with DMD.

CONCLUSIONS:

Patients with DMD have significantly different baseline CMR filling and ejection indices compared with controls. Some filling indices are associated with mortality and may be useful prognostic measures. Further research is needed in larger cohorts to determine the prognostic value of these differences.
Dialectical Analysis as a Research Method in the Works of L.S. Vygotsky
Authors: Veraksa Nikolay E.
Published: December 2024

Background. The cultural-historical theory of the development of higher mental functions by L.S. Vygotsky remains relevant and continues to be discussed by specialists from various countries. Its usefulness is largely due to its employment of the dialectical method, the analysis of which is the focus of this article.
Objectives. The aim is to reveal the essence of the dialectical method which allowed L.S. Vygotsky to analyse mental development processes. The first task was to define units of analysis as well as to describe their role when applied to a method. The second task was to show two types of analysis: substantive and structural.
Methods. The dialectical method of analysis was applied in the process of solving theoretical problems. The current article systematically raises questions about the characteristics of the method, the requirements for units of analysis and their properties. Several difficulties with analysing units were summarized.
Results. Dialectical analysis as a method of cognition, as applied by L.S. Vygotsky, was based on an invariant structural representation of the processes of mental development. At the same time, the task of meaningful interpretation of the development of the child’s psyche remained. The solution to this problem was based on the search for units of content analysis that simultaneously had two possibilities: to be invariant to any content and to be included into any content. An analysis of the works of L.S. Vygotsky showed that he considered the relations of opposition as such units.
Conclusions. The use of dialectical analysis by L.S. Vygotsky was associated with the consideration of the studied material on two levels: structural and substantive, as well as in transitions from one level to another. To make such transitions, L. S. Vygotsky identified opposites in the content that interested him. Opposites had both substantive properties and represented formal invariant units independent of specific content, which made it possible to carry out transformations at the invariant (structural) level before returning to the substantive level. As soon as the content of the problem under study was transmitted into a structural plan, it was subjected to dialectical transformations, through the sequential implementation of various operations using opposites. These operations corresponded to the elementary dialectical structures, characteristic of both mental transformations and the processes of various entities in development. Content analysis, which included operating with opposites, allowed L.S. Vygotsky to describe the processes of development of complex structural systems of human consciousness.
An Exercise in Husserl’s Constitutive Phenomenology: Exploring the Intentionality of Clinical Intuition
Authors: Churchill Scott D.
Published: December 2024

Inspired by Husserl’s (1913/1962, 1925/1977, 1931/1960, 1948/1973, 1954/1970) long term interest in problems of “constitution” at transcendental, psychological, and intersubjective levels, this study originally took up the question of the constitution of social perception in the context of the psychodiagnostic interview. More simply, the research question was: how do psychologists participate in forming a clinical impression? As reported earlier (Churchill 1984a, 19984b, 1998, 2006), data consisted of descriptions obtained from two clinical psychologists reflecting upon their experience during the interview phase of a diagnostic assessment, each of which was videotaped for later reference. These descriptions were obtained in writing, and served as a basis for further elaborating and clarifying their experience through a series of collaborative interviews. The descriptions and interview data were collated into a text of statements for each participant representing different perceptual “moments” distinguishable within the psychologist’s experience. The researcher performed an “intentional analysis” of these experiential moments within the data, posing the following question: What does this statement reveal about the meaning-constituting activity of the psychologist during this moment of the clinical encounter? The “intentional structure” of clinical impression formation was articulated in terms of three interconnected and essential constituents – constitutive projects and interests, modes of attention, and modes of explication – all characteristic of the psychologist’s presence to a patient. The current paper offers a further reflection upon the methodological virtues of the phenomenological method of intentional analysis with an aim to clarify how psychologists can fruitfully apply this philosophical psychological method in qualitative research investigations on perception, cognition, attention, attribution, reflexivity, and psychological understanding.
Reconceptualising Peace, Resisting Stigma
Authors: Edgcumbe Sarah
Published: December 2024

Much has been written about minorities in the Kurdistan Region of Iraq, yet Kurdish Gypsies have been consistently overlooked in various analyses of conflict, the socio-political arena, peacebuilding, and development. This paper is rooted in qualitative research conducted throughout early 2023 among a Kurdish Gypsy clan who self-identify as Hosta. The research is contextualized by the complicated nature of identity within a dominant Kurdish nationalist ideology which presents the KRI as a beacon of equity and cohesion. The paper utilizes an interdisciplinary theoretical framework to explore Hosta experiences of peace as characterized by structural violence and social (in)cohesion. Indicators of peace identified by Hosta in response to the degradation and poverty which they currently experience are presented alongside Hosta reactions and practices of everyday resistance to their enforced social positionality at the very bottom of the KRI’s hierarchy of citizenship.
Characterization of Subdaily Rainfall Events over Central Africa: Duration, Intensity, Amount, and Spatial Scale of the Storm Types
Authors: Mengouna François Xavier , Philippon N. , Vondou Derbetini A. , Moron Vincent , Maranan Marlon , Fink Andreas H.
Published: December 2024

Using half-hourly rainfall data from 14 automated weather stations over central Africa, rainfall events [≥0.1 mm (30 min)−1] characteristics are explored. A total of 10 096 wet events (WEs) were identified and classified into six storm types (STs), mostly discretized by their duration and intensity. ST 1 is very short (<1.5 h) with low rainfall intensities over a small area and contributes the least to the total rainfall (7%) but is by far the most frequent (70% of the WEs). ST 2 is short (∼1.5 h) and sudden with very intense rains and of medium spatial scale (<200 km). ST 3 is short and of medium scale too but with low intensities and rainfall amounts. ST 4 and ST 5 are of large scale and long (∼3–4 h), with high rainfall amounts so that they contribute the most to the total rainfall (29% and 20%). Last, ST 6 is the largest, longest, and rainiest, although moderately intense. A complementary classification is performed on lagged gridded rainfall fields from IMERG to document the possible space–time evolution of the rainfall field during the life cycle of WEs. Four spatial types are identified. Spatial type 1 gathers the most frequent, less intense ones. Spatial type 2 is far less frequent but pictures westward-moving rainfall patterns, probably associated with mesoscale convective systems. Two spatial types (3 and 4) are related to high-intensity near-stationary rainfall events, respectively, located to the southwest and northwest of the stations. ST 4 is mostly present at stations close to the Atlantic Ocean.
Jarring Encounters: Discomfort, Disruption, and Dominant Narratives of Suicide
Authors: Helman Rebecca , Huque Sarah I. , Chandler Amy
Published: December 2024

In researching experiences and understandings of suicide bereavement across diverse communities in Scotland, we expected to hear difficult, distressing, and painful narratives. However, one of the 31 in-depth qualitative interviews that we conducted was particularly and unexpectedly jarring. In this narrative, Freya explained how her ex-partner took his life after she escaped from his domestic abuse. This narrative produces a deep sense of discomfort in the interviewer, as her expectations about suicide bereavement are disrupted. Taking this discomfort as a starting point, we explore what this jarring encounter tells us about dominant and absent narratives of suicide. We interrogate how this narrative of suicide within the context of domestic violence perpetration bumps up against dominant narratives of a “male suicide crisis” and “relationship breakdown,” through which men are positioned solely as “victims.” Drawing on perspectives from feminist, affective, and reflexive qualitative research, critical suicide studies, and an abductive approach to analysis, we explore how attending to uncomfortable feelings that are generated within the research encounter can enable us to develop more complex, nuanced, and messy understandings of suicide.
Language is caught not taught: Parents’ use of bimodal bilingualism with their deaf children
Authors: Greene Ashley N. , Goyette Danielle , Metcalf Holly V. , Dixon Latoya K. , Eberwein Adele Ann , Clark M. Diane
Published: December 2024

Aims and objectives:

Bimodal bilingualism is a relatively new model for deaf children that involves the learning and utilization of two languages in the United States: American Sign Language (ASL) in the visual modality and English or another spoken language in the auditory modality. This approach involves using both sign language (visual modality) and spoken or written language (aural/oral modality).

Methodology:

A qualitative content analysis was conducted using semi-structured interviews to collect data from parents using a bimodal bilingual philosophy to raise their children.

Data and analysis:

This study investigated factors influencing parents’ decisions regarding the bimodal and bilingual development of their deaf child. A total of 14 families were identified.

Findings:

Most parents stated that they either knew or were exposed to deaf people and ASL or could obtain early intervention and support, knowing how to find resources for their child. Parents expressed a strong desire for their deaf child to be fully integrated into their family dynamics. They expressed high expectations for their child and saw them like any other family member. These parents valued bilingualism and did not see that bimodal bilingualism differed from learning two spoken languages.

Originality:

The model of bimodal bilingualism is relatively unknown, and no current studies have touched on multiple families’ choice to utilize bimodal bilingualism with their deaf children and what consequences emerged from doing so.

Implications:

Families that choose to utilize only oral/aural practices with their deaf child may notice negative effects on their child’s language development.

Limitations:

A future study should include more families, especially those with diverse cultures and backgrounds.
Honing CAR T cells to tackle acute myeloid leukemia
Authors: Haubner Sascha , Subklewe Marion , Sadelain Michel
Published: December 2024

Acute myeloid leukemia (AML) remains a dismal disease with poor prognosis, particularly in the relapsed/refractory (r/r) setting. Chimeric antigen receptor (CAR) therapy has yielded remarkable clinical results in other leukemias and thus has, in principle, the potential to achieve similar outcomes in r/r AML. Re-directing the approved CD19-specific CAR designs against the myeloid antigens CD33, CD123 or CLEC12A has occasionally yielded morphological leukemia-free states (MLFS) but has so far been marred by threatening myeloablation and early relapses. These safety and efficacy limitations owe in large part to the challenge of identifying suitable target antigens and designing adequate receptors for effective recognition and safe elimination of AML. Building on lessons learned from the initial clinical attempts, a new wave of CAR strategies relying on alternative target antigens and innovative CAR designs is about to enter clinical evaluation. Adapted multi-antigen targeting, logic-gating and emerging cell engineering solutions offer new possibilities to better direct T cell specificity and sensitivity towards AML. Pharmacologic modulation and genetic epitope engineering may extend these approaches by augmenting target expression in AML cells or minimizing target expression in normal hematopoietic cells. On/off switches or CAR T cell depletion may curb excessive or deleterious CAR activity. Investigation of AML-intrinsic resistance and leukemic microenvironmental factors is poised to reveal additional targetable AML vulnerabilities. We summarize here the findings, challenges and new developments of CAR therapy for AML. These illustrate the need to specifically adapt CAR strategies to the complex biology of AML to achieve better therapeutic outcomes.
Clinical heterogeneity of feeding and eating disorders: using personality psychopathology to differentiate “simplex” and “complex” phenotypes
Authors: Colizzi Marco , Comacchio Carla , Garzitto Marco , Bucciarelli Lavinia , Candolo Anna , Cesco Maddalena , Croccia Veronica , Ferreghini Alessandra , Martinelli Rosita , Nicotra Alessandra , Sebastianutto Giulia , Balestrieri Matteo
Published: December 2024

Background

To investigate Feeding and Eating Disorders (FED) heterogeneity based on the co-occurrence of FED symptoms and personality psychopathology, on the hypothesis that empirical profiles would not confirm current FED categories but identify unique phenotypes carrying different levels of clinical complexity.

Methods

Latent Profile Analysis profiled FED patients based on the assessment of both FED symptoms, through the Eating Disorders Inventory, third version (EDI-3), and personality characteristics, through the Minnesota Multiphasic Personality Inventory-2. Then, profiles were compared across socio-demographic and clinical characteristics.

Results

Among 109 eligible patients, three FED profiles were identified: (i) FED simplex (low eating symptoms, absence of dysfunctional personality); (ii) FED simplex-severe (high eating symptoms only); and (iii) FED complex-severe (high eating symptoms and dysfunctional personality). Despite an uneven distribution (χ2(6) = 15.20, adjusted-p = 0.029), FED profiles did not unequivocally confirm clinical diagnoses (e.g., Anorexia Nervosa). A difference in Body Mass Index (BMI) was observed (K(2) = 15.06, adjusted-p = 0.001), but lower BMI did not identify the most severe group. Profiles differed in EDI-3 overall scores (e.g., Eating Disorder Risk Composite: K(2) = 43.08, adjusted-p < 0.001), Body Uneasiness Test Global Severity Index (GSI: K(2) = 29.33, adjusted-p < 0.001), Binge Eating Scale severity (K(2) = 25.49, adjusted-p < 0.001), number of psychiatric (K(2) = 8.79, adjusted-p = 0.021) and personality diagnoses (K(2) = 11.86, adjusted-p = 0.005), and Symptom Checklist-90-Revised GSI (F(2,103) = 37.68, adjusted-p < 0.001), with FED complex-severe patients being generally the most severely impaired in terms of FED symptoms, body concerns, depersonalization, and psychiatric comorbidities.

Conclusions

Findings support the hypothesis of distinguishing FED simplex and complex phenotypes, based on the co-occurrence of dysfunctional personality, with implications for FED severity and clinical practice.