bluuebunny/crossref_metadata_2025 huggingface dataset:
A memetic-based technical indicator portfolio and parameters optimization approach for finding trading signals to construct transaction robot in smart city era
Authors: Chen C.H. , Hung S.T. , Chen P.T. , Wang C.S. , Chiang R.D.
Published: August 2023

With the development of smart cities, the demand for personal financial services is becoming more and more importance, and personal investment suggestion is one of them. A common way to reach the goal is using a technical indicator to form trading strategy to find trading signals as trading suggestion. However, using only a technical indicator has its limitations, a technical indicator portfolio is further utilized to generate trading signals for achieving risk aversion. To provide a more reliable trading signals, in this paper, we propose an optimization algorithm for obtaining a technical indicator portfolio and its parameters for predicting trends of target stock by using the memetic algorithm. In the proposed approach, the genetic algorithm (GA) and simulated annealing (SA) algorithm are utilized for global and local search. In global search, a technical indicator portfolio and its parameters are first encoded into a chromosome using a bit string and real numbers. Then, the initial population is generated based on the encoding scheme. Fitness value of a chromosome is evaluated by the return and risk according to the generated trading signals. In local search, SA is employed to tune parameters of indicators in chromosomes. After that, the genetic operators are continue employed to generate new offspring. Finally, the chromosome with the highest fitness value could be provided to construct transaction robot for making investment plans in smart city environment. Experiments on three real datasets with different trends were made to show the effectiveness of the proposed approach, including uptrend, consolidation, and downtrend. The total returns of them on testing datasets are 26.53% 33.48%, and 9.7% that indicate the proposed approach can not only reach risk aversion in downtrends but also have good returns in others.
FMRI Complexity Correlates with Tau-PET and Cognitive Decline in Late-Onset and Autosomal Dominant Alzheimer’s Disease
Authors: Jann Kay ,   for the Alzheimer’s Disease Neuroimaging Initiative, Boudreau Julia , Albrecht Daniel , Cen Steven Y. , Cabeen Ryan P. , Ringman John M. , Wang Danny J.J.
Published: August 2023

Background: Neurofibrillary tangle pathology detected with tau-PET correlates closely with neuronal injury and cognitive symptoms in Alzheimer’s disease (AD). Complexity of rs-fMRI has been demonstrated to decrease with cognitive decline in AD. Objective: We hypothesize that the rs-fMRI complexity provides an index for tau-related neuronal injury and cognitive decline in the AD process. Methods: Data was obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI3) and the Estudio de la Enfermedad de Alzheimer en Jalisciences (EEAJ) study. Associations between tau-PET and rs-fMRI complexity were calculated. Potential pathways relating complexity to cognitive function mediated through tau-PET were assessed by path analysis. Results: We found significant negative correlations between rs-fMRI complexity and tau-PET in medial temporal lobe of both cohorts, and associations of rs-fMRI complexity with cognitive scores were mediated through tau-PET. Conclusion: The association of rs-fMRI complexity with tau-PET and cognition, suggests that a reduction in complexity is indicative of tau-related neuropathology and cognitive decline in AD processes.
Rheumatoid Arthritis and Cognitive Impairment or Dementia: An Updated Review of Epidemiological Data
Authors: Sharma Sneha R. , Chen Yu
Published: August 2023

Rheumatoid arthritis (RA) is hypothesized to be associated with cognitive impairment and dementia, including Alzheimer’s disease, through shared biological processes related to inflammation. It is important to elucidate this potential relationship as both conditions confer increased morbidity and even mortality among older adults. This narrative review provides a survey of recent epidemiologic studies, examining the association between rheumatoid arthritis and either dementia or cognitive impairment. Sixteen studies were included after searching in PubMed and EMBASE. All were published between 2012 and 2022 and were characterized as epidemiologic studies (either cohort, cross-sectional, or case-control). Studies varied in location, design, measures of exposure and outcome, and covariates considered. Of the 16 studies included, only five found statistically significant positive associations between RA and dementia or cognitive impairment. One study found an inverse relationship, while five studies found no associations at all. The remaining five studies found variable statistically significant associations between demographic or RA disease characteristics and cognitive measures. Given these mixed findings, further studies at both the mechanistic and population level are needed to clarify the possible shared biological underpinnings of these two conditions.
Influence of loss function on training the LSTM network in wall moisture tomography
Authors: Rymarczyk Tomasz , Kulisz Monika , Kłosowski Grzegorz
Published: August 2023

This study concerns research on using electrical impedance tomography (EIT) to image moisture inside the porous walls of buildings. In order to transform the electrical measurements into the values of the reconstructed 3D images, a neural network containing the LSTM layer was used. The objective of the study was to evaluate the impact of various loss functions on the efficacy of a neural network’s learning process. During the training process, three distinct variations of the loss function were employed, namely mean squared error (MSE), Huber, and a hybrid of MSE + Huber, to attain the desired outcome. Given that the primary focus of the study was on the loss function, the particular neural network architecture employed was deemed non-essential. In order to minimize the influence of the neural network architecture on the outcomes of the test, a comparatively uncomplicated neural model was implemented, comprising a solitary LSTM layer and a single fully connected layer.
Artificial intelligence changing the future of healthcare diagnostics
Authors: Mishra Vaishnavi , Ugemuge Sarita , Tiwade Yugeshwari
Published: August 2023

Artificial intelligence (AI) is a computer’s capacity to carry out operations like speech and image recognition and decision-making that ordinarily require human intelligence. Healthcare is using AI to automate tasks such as medical image analysis and diagnosis that require high precision and accuracy. The healthcare industry is significantly impacted by the rapid development of machine learning algorithms, which are frequently implemented using deep learning, as well as the growth of digital data and computing power supported by improvements in hardware technologies. Significant progress has been made in the field of artificial intelligence in recent years and is now widely used in healthcare to automate a variety of tasks, which require a high degree of accuracy and precision. The creation of machine learning algorithms, which can learn from data and make predictions based on that learning, has made it possible to use AI in healthcare. Neural networks are used in deep learning, a subfield of machine learning, to simulate how the human brain functions. Crucial advances have been made in clinical decision support, drug discovery, and medical imaging. Furthermore, the rapid development of hardware technologies, such as graphics processing units, has allowed AI systems to process enormous amounts of data quickly and accurately. Due to this, AI-based tools and platforms can help healthcare professionals with tasks such as patient monitoring, disease diagnosis, and treatment planning.
Automatic summarization of long text of Chinese patents based on PatBertsum model
Authors: Zhu Chang-Sheng , Qin Peng
Published: August 2023

Aiming at the problems of traditional text abstract extraction algorithms for processing long text of Chinese patents and unsatisfactory results of long abstract generation, the PatBertSum algorithm is proposed, which enables the algorithm to process long (more than 1500 words) patent text with high efficiency and generate high-quality long (more than 200 words) text summaries. The method is based on the improved BertSum algorithm model, using the new CLTPDS patented text dataset, processing long texts by Head-Tail, transforming Chinese input representations, generating sentence vectors using a pre-trained model, and capturing internal text features and text structure features to extract summaries. Experimentally, this paper demonstrates that the method has improved the recall and F-value of ROUGE by more than 8 percentage points compared with existing methods.
A novel framework for comprehensive value evaluation of cultural tourism resources with 2-tuple linguistic neutrosophic numbers multiple attribute decision making
Authors: Hou Jundan , Liu Qian , Dong Qi
Published: August 2023

In recent years, with the rapid growth of the public’s demand for cultural connotation and cultural taste of tourism products, promoting the rapid development of the integration of cultural tourism, the development of cultural tourism boom has been set off nationwide. Cultural tourism resources are the premise and foundation of cultural tourism development. With the rise of cultural tourism fever, the collation and excavation of the cultural connotation and cultural value of various types of cultural tourism resources around the world has entered a more in-depth stage, which undoubtedly promotes the industrial transformation and utilization of resources, but in terms of the evaluation of the value of resources, there are more qualitative evaluations and few quantitative evaluations, which is largely due to the current academic classification of cultural tourism resources is not uniform, so that the evaluation of resources This is largely due to the difficulty of establishing the index system in the current academic community. The comprehensive value evaluation of cultural tourism resources is looked as the multiple attribute decision making (MADM) issue. In this paper, we extended the dua Hamy mean (DHM) operator and power avergae (PA) operator to 2-tuple linguistic neutrosophic sets (2TLNSs) to propose the 2-tuple linguistic neutrosophic power DHM (2TLNPDHM) operator. Finally, a decision example for comprehensive value evaluation of cultural tourism resources is employed to show the 2TLNPDHM operator.
Developing aquila optimization-based fuzzy system to predict the mechanical properties of the improved HPC
Authors: Ji YingZhou , Niuo Qiang
Published: August 2023

High-performance concrete performs better than normal concrete because of using additional components than usual concrete components. Several artificially based analytics were used to evaluate the compressive strength (CS) of high-performance concrete (HPC) made with fly ash and blast furnace slag. In the present research, the Aquila optimizer (AO) was used to find the best values for the determinants of the adaptive neuro-fuzzy inference system (ANFIS), and radial basis function neural network (RBFNN) that may be changed to enhance performance. The suggested approaches were established using 1030 tests, eight inputs (a primary component of mix designs, admixtures, aggregates, and curing age), and the CS as the forecasting objective. The results of the outperformed model were then contrasted with those found in the existing scientific literature. Calculation results point to the potential benefit of combining AO-RBFNN and AO-ANFIS study. The AO-ANFIS demonstrated significantly higher R2 (Train: 0.9862, Test: 0.9922) and lower error metrics (such as: RMSE at 2.1434 (train) and 1.2763 (Test)) when compared to the AO-RBFNN and previously published articles. In summation, the proposed method for determining the CS of HPC supplemented with blast furnace slag and fly ash may be established using the suggested AO-ANFIS analysis.
Evolutionary design method for transforming ceramic cultural elements into cultural and creative products
Authors: Wu Yixiang
Published: August 2023

Cultural and creative products are empowered through cultural connotation in the market with ever-changing customer needs. Analyzing user preferences and matching them with product design elements has become the focus of research. Taking ceramic bracelet as the research example, this study proposed an evolutionary system which integrates the interactive genetic algorithm with artificial neural network and fuzzy analytic hierarchy process based on evaluation grid method. First, the cultural genes were extracted from cultural products as the design elements. Second, the attractiveness characteristics of the products and customer demand dimension information were analyzed by evaluation grid method. Third, the fuzzy analytic hierarchy process was used to assign weight values to the 3 users’ perceptual evaluation vocabularies. Fourth, the artificial neural network algorithm was incorporated into the fitness evaluation stage of the interactive algorithm to reduce information distortion caused by evaluation fatigue. Finally, after training the samples using the back propagation neural network, 8 design schemes with a fitness value exceeding 4.5 were obtained. The iterative curve indicated that after the 51st generation, the error accuracy approached 0.09. The experimental results verified that the system could help to improve the efficiency of product design, and design products that are more in line with user needs.
Feature interaction and two-stage cross-modal fusion for RGB-D salient object detection
Authors: Yu Ming , Liu Jiali , Liu Yi , Yan Gang
Published: August 2023

Most existing RGB-D salient object detection (SOD) methods extract features of both modalities in parallel or adopt depth features as supplementary information for unidirectional interaction from depth modality to RGB modality in the encoder stage. These methods ignore the influence of low-quality depth maps, and there is still room for improvement in effectively fusing RGB features and depth features. To address the above problems, this paper proposes a Feature Interaction Network (FINet), which performs bi-directional interaction through feature interaction module (FIM) in the encoder stage. The feature interaction module is divided into two parts: depth enhancement module (DEM) filters the noise in the depth features through the attention mechanism; and cross enhancement module (CEM) effectively interacts RGB features and depth features. In addition, this paper proposes a two-stage cross-modal fusion strategy: high-level fusion adopts the semantic information of high level for coarse localization of salient regions, and low-level fusion makes full use of the detailed information of low level through boundary fusion, and then we progressively refine high-level and low-level cross-modal features to obtain the final saliency prediction map. Extensive experiments show that the proposed model achieves better performance than eight state-of-the-art models on five standard datasets.
Categorization of crowd-sensing streaming data for contextual characteristic detection
Authors: Kisters Philipp , Schreiber Hanno , Edinger Janick
Published: August 2023

The growing reliance on large wireless sensor networks, potentially consisting of hundreds of nodes, to monitor real-world phenomena inevitably results in large, complex datasets that become increasingly difficult to process using traditional methods. The inadvertent inclusion of anomalies in the dataset, resulting from the inherent characteristics of these networks, makes it difficult to isolate interesting events from erroneous measurements. Simultaneously, improvements in data science methods, as well as increased accessibility to powerful computers, lead to these techniques becoming more applicable to everyday data mining problems. In addition to being able to process large amounts of complex streaming data, a wide array of specialized data science methods enables complex analysis not possible using traditional techniques. Using real-world streaming data gathered by a temperature sensor network consisting of approximately 600 nodes, various data science methods were analyzed for their ability to exploit implicit dependencies embedded in unlabelled data to solve the complex task to identify contextual characteristics. The methods identified during this analysis were included in the construction of a software pipeline. The constructed pipeline reduced the identification of characteristics in the dataset to a trivial task, the application of which led to the detection of various characteristics describing the context in which sensors are deployed.
Candidate Potential for Studies of A ≥ 1600 Superheavy Nuclei
Authors: Bevelacqua Joseph
Published: August 2023

Uncertainties in the nuclear interaction for A ≥ 1600 superheavy nuclei preclude absolute theoretical predictions of nuclear properties including single-particle energies, half-lives and Q-values. However, a model potential can be developed to predict trends in these properties and suggest islands of stability in A ≥ 1600 nuclei. The Rost-1600 interaction is derived from the Rost interaction by increasing its potential strength by 15%. This interaction will be used in subsequent studies of A ≥ 1600 nuclei.
SELECTION OF SOYBEAN LINES BASED ON A NUTRACEUTICAL IDEOTYPE
Authors: Sangiovo Jaqueline Piesanti , Carvalho Ivan Ricardo , Pradebon Leonardo Cesar , Loro Murilo Vieira , Port Eduarda Donadel , Barasuol Scarton Victor Delino , Hickembick Zuse Guilherme , Sfalcin Inaê Carolina , Foleto Eduardo Ely
Published: August 2023

This study aims to select soybean lines with desirable nutraceutical characteristics under specific meteorological conditions in the selection environments. The experiment was conducted during the 2021/2022 harvest at Escola Fazenda, Regional University of the Northwest of the State of Rio Grande do Sul, located in Augusto Pestana- RS, Brazil. The experimental design was augmented blocks, with 27 populations of F2 generation, 118 lines of F5 generation, 70 lines of F8 generation, and 15 soybean cultivars as interim checks, arranged in three replications. The chemical composition of soybeans was evaluated using Near Infrared Spectroscopy - NIRS method to analyze various nutritional components. The IRC050 genotype exhibited a nutraceutical profile characterized by an increment in stearic fatty acid (STEAR) and reduction in fiber (FB) and mineral material (MM) contents. Among the F5 generation, the following genotypes were selected based on their nutraceutical traits: L174F5, L307F5, L322F5, L205F5, L190F5, L196F5, L219F5, L183F5, L301F5, L172F5, L198F5, L182F5, L319F5, L21F5, L188F5, L217F5, L302F5, L315F5, L36F5, L318F5, L211F5, L165F5, L321F5, and L179F5. The indirect selection of genotypes with higher levels of linoleic acid and protein was facilitated using the enzyme peroxidase.
ANALISIS PENGARUH LEMBAGA KEUANGAN MIKRO SYARIAH DAN LEMBAGA PEMBIAYAAN SYARIAH TERHADAP PERTUMBUHAN EKONOMI INDONESIA TAHUN 2015-2021
Authors: Riski Muhammad Riski Anugerah Pratama , Shauqi Shauqi Aditya Khalis
Published: August 2023

Perkembangan pertumbuhan ekonomi lebih besar bergantung bagaimana perjalanan sektor rill dengan harapan adanya kontribusi dari sektor rill tersebut berupa keuntungan yang bisa mengembangkan pendapatan masyarkat dan lancarnya kegiatan perekonomian. Salah satunya yang dapat mengembangkan sektor rill itu ialah pembiayaan yang disalurkan untuk para pelaku usaha atau bagi pihak yang berperan langsung dalam pengembangan sektor rill itu. Oleh karena peneliti ingin mengulas bagaimana pengaruh antara Lembaga keuangan mikro syariah dan Lembaga pembiayaan syariah terhadap pertmbuhan ekonomi indonesia tahun 2015-2021. Metode penelitian yang dipakai yaitu dengan kuantitatif dengan menggunakan analisis regresi linier berganda. Data yang diambil yaitu dari perkembangan aset lembaga keuangan mikro syariah dan lembaga pembiayaan syariah serta PDB atas harga konstan menurut lapangan usaha indonesia pada tahun 2015-2021 untuk variable pertumuhan ekonomi. Hasil analisis menyatakan bahwa lembaga keuangan mikro syariah dan lembaga pembiayaan syariah berpengaruh secara simultan terhadap pertumbuhan ekonomi sedangkan secara parsial lembaga keuangan mikro syariah memiliki pengaruh yang positif dan signifikan terhadap pertumbuhan ekonomi dan lembaga pembiayaan syariah secara parsial mempunyai pengaruh yang positif dan tidak signifikan terhadap pertumbuhan ekonomi indonesia tahun 2015-2021.
TINGKAT LITERASI DAN INKLUSI KEUANGAN SYARIAH PADA MASYARAKAT KOTA BANDA ACEH
Authors: Muksal Muksal , Nevi Hasnita  , Putri Nazirah
Published: August 2023

High financial literacy and inclusion have a positive impact on individuals, financial institutions and increase the country's economic growth. This study aims to determine the level of literacy and inclusion of Islamic finance in the city of Banda Aceh after the implementation of Qanun No. 11 of 2018 concerning Islamic Financial Institutions. This study used a descriptive qualitative method using a questionnaire. The results showed that there was an increase in the Islamic financial literacy level from 71.99% to 89.70% with an Islamic financial inclusion rate of 83.4%. If categorized into financial literacy and inclusion criteria according to Chen and Volpe, the Islamic financial literacy and inclusion of the people of Banda Aceh City are in the high category.
Comparative analysis of various global maximum power point tracking techniques for fuel cell frameworks
Authors: Khan Mohammad Junaid , Mustafa Rashid , Pal Pushparaj
Published: August 2023

The efficiency and performance of fuel cell (FC) systems heavily rely on their ability to track the maximum power point (MPP) of the FC stack. This research article presents a comprehensive review and comparative analysis of various global maximum power point tracking (GMPPT) techniques developed for FC systems. These techniques aim to optimize power extraction from FCs, enhance system efficiency, and improve overall performance. Through a detailed investigation and evaluation of different GMPPT methods, this study sheds light on the advancements made in this field, identifies key challenges, and provides recommendations for future research directions. The findings of this research contribute to the development of more efficient and reliable FC systems for diverse applications.
Ulceras Angiodérmicas e Câncer
Authors: Lucas Hiram , Barbosa Amaury
Published: August 2023

Os AA. estudam 39 (trinta e nove) casos de Úlceras Angiodérmicas malignizadas, constando de material do Instituto Nacional de Câncer no qüinqüênio 1980/65. Defendem a nomenclatura especial para este processo, tendo em vista estarem já perfeitamente marcados os seus fatores determinantes, alicerçados sôbre o binômio insuficiência venosa crônica — componente dérmico (capilarite). Descrevem, a partir daqui, como se constitui, os fatores que influem em sua evolução, discutindo como se processa a invasão do plano ósseo. Detém-se na transformação maligna de processo, com suas características macroscópicas e as sutilezas histopatológicas. Discutem depois a casuística apresentada, prendendo-se em especial, a dados de diagnóstico e tratamento. Por fim, referem-se à evolução dos casos, a despeito do curto espaço de tempo que transcorreu.
Clinical Aspects and Diagnosis of Hodgkin’s Disease
Authors: Ultmann John E.
Published: August 2023

Apresentações feitas no Simpósio Internacional sobre Doença De Hodgkin, realizado no Instituto Nacional de Câncer no Rio de Janeiro — 16 a 20 de Janeiro de 1967.
Treatment of Early and Advanced Hodgkin’s Disease by Radiotherapy
Authors: Kaplan Henry S.
Published: August 2023

Resumo apresentado no Simpósio Internacional sobre Doença de Hodgkin, realizado no Instituto Nacional de Câncer no Rio de Janeiro — 16 a 20 de Janeiro de 1967. Resumo da apresentação, escrito pelo autor.
The Role of Chemotherapy in the Treatment of Hodgkin’s Disease
Authors: Karnofsky David A.
Published: August 2023

Trabalho apresentado no Simpósio Internacional sobre Doença de Hodgkin, realizado no Instituto Nacional de Câncer no Rio de Janeiro — 16 a 20 de Janeiro de 1967. Transcrição da gravação, revisto o original pelo autor.
Importância da Radioterapia no Tratamento Primário do Câncer da Mama
Authors: Fletchee Gilbert H. , Montague Eleanor D. , White Edgard C.
Published: August 2023

Esta investigação foi feita sob os auspicios da Public Health Service Research, Grants Nys CA-0629 e CA-05654 do National Câncer Institute. Conferência realizada no Serviço de Câncer — Rio de Janeiro, em 14-12-1967.
Planejamento Geral do Tratamento do Câncer da Mama
Authors: Araújo A. Eiras de
Published: August 2023

Depois de salientar que os métodos clássicos de tratamento do câncer da mama mastectomias mais ou menos radicais, associadas ou não à radioterapia — já deram tudo o que dêles se pode esperar, o Autor salienta a necessidade de serem tentadas novas orientações neste momentoso problema. Enquanto a imunologia — talvez o caminho do futuro — não tenha chegado a resultados mais concretos, opina pela adoção sistemática da quimioterapia no pós-operatório dos Estádios I e II. os únicos operáveis em sua opinião. A seguir expõe sua conduta terapêutica nos diversos estadiamentos da doença.
A Influência do Meio Ambiente Tissular Local, no Crescimento de Células Cancerosas Disseminadas
Authors: Southam Chester M.
Published: August 2023

Resumo da Conferência proferida no Simpósio Internacional de Biologia das Metástases, realizado no Instituto Nacional de Câncer Rio de Janeiro Setembro de 1967.
Estudos Sôbre Regulação Metabólica Contrôle de Síntese de Proteínas: V - Ação da Glicose na Regulação da Tirosina Alfa Ceto Glutarato Transaminase em Fígado de Rato
Authors: Faria Mauro C. , Mello F. G. , Preza P. , Faria H.C.
Published: August 2023

É demonstrado que a administração de glicose provoca a diminuição da atividade da tirosina transaminase em fígado de rato. Este efeito “repressor” se apresenta em animais normais ou diabéticos por aloxanização, nos quais foi induzida por corticóides, ou, nos quais a enzima foi induzida por corticóides, ou, ainda, sôbre níveis basais da enzima. A administração de florindizina, não impedindo a indução, evita, contudo, o efeito repressor da glicose. É sugerido que a glicose ou metabolito à ela relacionado seja o controlador da atividade de TT, pois toda interferência no metabolismo glicose - glicogênio - glicose seja por efeito hormonal, por modificação da dieta, por florindizina etc..., determina significante variação dos níveis de TT no fígado.
Estudos Sôbre Regulação Metabólica Contrôle de Síntese de Proteínas: V - Ação da Glicose na Regulação da Tirosina Alfa Ceto Glutarato Transaminase em Fígado de Rato
Authors: Faria Mauro C. , Mello F. G. , Preza P. , Faria H. C.
Published: August 2023

O presente trabalho demonstra que o efeito “repressor” da glicose sôbre TT no fígado não se apresenta se o animal fôr previamente tratado com 5-PU. Porém, o 5-FU não evita o efeito da glicose, se fôr administrado depois dêste glicidio. É sugerida a hipótese de que o efeito da glicose só se faz presente quando já existe “repressor” pré-formado, isto é, sua ação seria a estabilização deste sistema “repressor”.
Sistema Linfático: Revisão Crítica de Sua Anatomia e Fisiologia
Authors: Lucas Hiram Silveira
Published: August 2023

O autor depois de bosquejo histórico sôbre a descoberta e a progressiva aquisição de conhecimento sôbre o sistema linfático através dos séculos descreve o desenvolvimento embrionário do referido sistema. Segue-se revisão crítica da anatomia e fisiologia na qual os aspectos práticos são valorizados. Numerosas ilustrações em forma de esquemas e fotografias complementam a explanação.
Valor da Citologia Esfoliativa no Diagnostico Precoce do Carcinoma da Mama
Authors: Coutinho Alberto , Neves Edesio M.
Published: August 2023

Os autores relatam o diagnóstico de 3 casos de carcinoma ductal não infiltrante pelo exame citológico da descarga mamilar de 1.450 pacientes do Instituto Nacional de Câncer; as 3 pacientes, nas quais ficou demonstrada a presença de células malignas na secreção mamilar, não apresentavam nem tumor palpável nem qualquer outro sinal ou sintoma além de descarga mamilar; estão vivas, passando bem, após tratamento cirúrgico efetuado há 14, 10 e 5 anos. Tais são as possibilidades da citologia esfoliativa na detecção e diagnóstico precoce do câncer da mama.
Papel das Histonas na Divisão e Diferenciação Celular. I - Estudo das Diferenças Percentuais Entre Histonas de Fígado Normal de Rato e de Tumor Ascítico de Ehrlich
Authors: Preza Paulo C. A. , Pires Ernani T. , Fialho Maria Cristina A. , Mello Fernando G. , Faria Mauro C.
Published: August 2023

A extração de histona de fígado normal de rato e de células ascíticas de Ehrlich, por CM-Celulose, evidenciou variações nítidas nas percentagens das frações fx, f2 e f3. A fração fx, não histona, apresentou maior percentagem nas células tumorais, enquanto nestas mesmas células houve uma diminuição da percentagem das frações f2 e f3. São discutidas as implicações destas diferenças no mecanismo de controle da divisão celular.
Atividades da IV reunião de presidentes e diretores de entidades participantes da campanha nacional de combate ao câncer
Authors: Lucas Hiram Silveira
Published: August 2023

A IV RPDEPCNCC foi realizada entre os dias 23 e 26 de setembro de 1968, no auditório do Instituto Nacional de Câncer, simultaneamente às comemorações do XXX Aniversário de sua Fundação. A Seção de Organização e Controle (SOC) planejou as atividades realizadas, contando com a inequívoca colaboração da Diretoria do Centro de Estudos e Ensino do INC.
Quimioterapia para câncer de mama no estado do Rio de Janeiro frente à pandemia de Covid-19: uma análise de séries temporais
Authors: Santos Natalia Farias , Osorio-de-Castro Claudia Garcia Serpa , Sobreira-da-Silva Mario Jorge
Published: August 2023

Introdução: O câncer é uma das principais causas de morte no Brasil e no mundo. Estimam-se 483 mil novos casos no país, para cada ano do triênio 2023-2025, excetuando-se o câncer de pele não melanoma, sendo o câncer de mama o mais incidente em mulheres, com 74 mil novos casos. Após a declaração da pandemia da covid-19 pela Organização Mundial da Saúde, vários Estados brasileiros estabeleceram medidas restritivas, visando à redução da contaminação, e os centros de referência em diagnóstico do câncer foram impactados. Objetivo: Analisar séries temporais das quantidades de procedimentos aprovados de quimioterapia para câncer de mama antes e durante a pandemia da covid-19 nos estabelecimentos habilitados para alta complexidade em oncologia no Estado do Rio de Janeiro. Método: Estudo descritivo com análises de séries temporais e ecológica, usando dados públicos de procedimentos de quimioterapia autorizados pelo Sistema Único de Saúde entre março de 2018 e fevereiro de 2021. Resultados: Foram identificados 394.926 procedimentos, representando um aumento de 47% com tendência linear crescente (R2=0,5203) no período. Verificou-se um aumento de procedimentos para câncer de mama receptor hormonal positivo (46%) e carcinoma de mama HER-2 positivo (900%). Conclusão: Observou-se um aumento nos procedimentos de quimioterapia, assim como uma diminuição do deslocamento de tratamento dos grandes centros. Os resultados apontam para uma possível resposta efetiva da rede de atendimento e fortalecimento da regionalização durante o primeiro ano da pandemia.
Niveles de Vitamina D y morbimortalidad en el recién nacido prematuro de muy bajo peso al nacer
Authors: Vera Almonacid Maria Paz , Bancalari Molina Aldo
Published: August 2023

Los recién nacidos prematuros de muy bajo peso al nacer (RNMBPN), carecen de algunos nutrientes como la vitamina D (VD), importante en la función y desarrollo de diferentes sistemas. Objetivo: Evaluar los niveles de séricos de 25-OH-VD en RNMBPN y describir la posible asociación entre su déficit y morbilidades frecuentes en esta población. Pacientes y Método: Estudio transversal de RNMBPN (< 1.500 g y/o < 32 semanas de edad gestacional). Se realizó medición única de niveles séri- cos de 25-OH-VD en las primeras 72 horas de vida post-natal (inmunoensayo quimioluminiscente). Se analizaron características perinatales, tratamientos efectuados y comorbilidades frecuentes. El déficit de 25-OH-VD se definió con niveles ≤ 20 ng/ml, y se determinó asociación estadística entre éste y diversas comorbilidades al alta hospitalaria en su período neonatal. Resultados: Se evaluaron 46 neonatos prematuros. El nivel sérico promedio de 25-OH-VD fue 19,7 ± 6,7 ng/ml. Un 52,2% (24/46) presentó niveles deficitarios, observándose valores más bajos a menor edad gestacional (p = 0,01). Se observó asociación entre el déficit de 25-OH-VD, la necesidad de ventilación mecánica convencional (p = 0,04), y mayor estadía hospitalaria (p < 0,01). Existió asociación con la presencia de ductus arterioso hemodinámicamente significativo (p < 0,01). Conclusiones: El déficit de 25-OH-VD fue frecuente en RNMBPN, existiendo menores niveles a menor edad gestacional. Se observó asociación entre el déficit de 25-OH-VD, la estadía hospitalaria, necesidad de soporte respiratorio, y el ductus arterioso persistente.
Dental trauma in childhood: integrative review
Authors: Gomes Mariana Amélia Sena , Silva Kedson de Sousa , Meira Gabriela de Figueiredo , Oliveira Nayhane Cristine da Silva de , Araujo Priscila Pinto Brandão de
Published: August 2023

The aim of this work is to conduct a literature review on aspects of dental trauma in deciduous dentition, based on data found in the PUBMED, LILACS, BBO, and SCIELO databases regarding the proposed topic. Trauma to deciduous teeth occurs in preschool children and is often associated with behavioral traits such as curiosity and restlessness, leading children to explore environments that result in falls, leading to an increased incidence of injuries. The success of post-traumatic care is related to the emergency care provided at the time of the event, as delayed treatment can result in a series of problems according to the trauma suffered. To avoid problems resulting from trauma and delayed treatment, there are protocols and guidelines that can be used in the treatment of dental trauma, with each treatment corresponding to a type of trauma.
Docência e a incorporação das midias digitais no ensino fundamental II no Brasil: inovações e visão
Authors: Cruz Zuleica Oliveira , Costa Luciane Cunha da , Dendasck Carla Viana , Souza Eliane Silva
Published: August 2023

Sendo um dos organismos da sociedade civil, a escola é o local, por excelência, para o desenvolvimento do processo de transmissão-assimilação do conhecimento elaborado. Talvez, por isso que os profissionais de educação estejam enfrentando novos desafios na sua prática pedagógica com o advento das tecnologias digitais no espaço escolar. Atenta a esta nova realidade, este estudo procurou investigar de que forma o profissional de educação no Ensino Fundamental 2 está incorporando as mídias digitais no processo de ensino e conhecer as concepções dos docentes acerca da utilização de mídias digitais no cotidiano escolar, assim como identificar os principais obstáculos que tem este profissional em aliar a mídia digital à prática educativa, e analisar os princípios norteadores de práticas pedagógicas articuladas ao processo inovador de mídia digital. Para tanto, utilizamos, como metodologia, a pesquisa bibliográfica e a pesquisa etnológica, levando em consideração o ProInfo (Programa Nacional de Informática na Educação) que foi responsável pela implantação do laboratório de informática na escola onde a pesquisa aconteceu motivada pela observação do ambiente.
МЕХАНІЗМ УТВОРЕННЯ СИСТЕМИ ВТОРИННИХ КОНЦЕНТРИЧНИХ МЕМБРАН У ВИЩИХ ВОДНИХ РОСЛИН ПРИ ДІЇ ТОКСИЧНИХ РЕЧОВИН НА ПРИКЛАДІ LÉMNA MINOR L.
Authors: Костюк Катерина Василівна , Грубінко Василь Васильович , Боднар Оксана Ігорівна , Чвалюк Галина Василівна
Published: August 2023

Важко собі уявити, що така складна структура, як клітинна мембрана, може бути відновлена, однак вона відновлюється за рахунок регенерації часткових розривів або синтезу вторинної концентричної мембрани. Здатність багатьох організмів до регенерації часткових розривів їхньої клітинної мембрани добре вивчена [1; 2; 3]. Коли клітини пошкоджені, вони швидко відновлюють пошкодження в мембрані, з утворенням однієї або більше нерозчинних корків, що складаються з ліпідів та полісахаридів, щоб запобігти втраті вмісту цитоплазми. Згодом клітини відновлюють свій первісний обсяг та форму [4; 5]. Враховуючи великий розмір клітин, слід розуміти, що цих пробоїв може бути багато. Тут задіяні інші процеси, пов’язані з утворенням системи вторинних концентричних мембран [6]. Наші результати показують, що вторинна мембрана не є тимчасовою, і функції вона виконує такі, як і первинна клітинна мембрана, а її утворення триває всього кілька годин. У цьому дослідженні ми надаємо повний опис того, як утворюється вторинна концентрична мембрана, а також етапність цього процесу та значення при адаптації. Повне пояснення того, як ці клітини відновлюють пошкоджену мембрану, у тому числі клітинну стінку, залишається ще визначити. Тому метою цієї статті було вивчення процесів утворення вторинної концентричної мембрани та клітинної стінки на прикладі вищих водних рослин Lémna minor L. Регенерація клітинної оболонки може бути важливою моделлю вивчення таких процесів, як взаємодія різних клітинних органел, формування різних типів гібридних клітин і особливо, еволюції клітинних мембран. В спонтанній регенерації клітинної оболонки можна виділити чотири основні стадії: 1) утворення протопласту; 2) формування псевдо-протопласту; 3) синтез клітинної стінки; 4) формування вторинної концентричної мембрани.
EFFECT OF VITAMIN D3 ON HEMATOLOGIC INDICES AND RESISTANCE OF LAYING HENS
Authors: Pakholkiv Nataliia , Nevostruyeva Iryna , Hudyma Volodumura
Published: August 2023

The content of vitamin D3 in standard fodder for laying hens varies within 2,5-3,500 IU / kg. It is known that vitamin D is involved in bone metabolism and regulates calcium homeostasis in the body. Experiment was carried out in three groups of laying hens of the crossbreed Hayesks brown, which for 30 days fed fodder, the content of vitamin D3 in which was respectively 2,5; 5,0 and 10,0 thousand IU / kg. An increase in the content of vitamin D3 from 2.5 to 10.0 thousand IU / kg increased the concentration of 25-OH D3 in blood plasma by half (from 15.10 to 27.25 ng / ml). The dose of 5.0 ths. IU / kg did not affect the concentration of 25-OH D3 (16.56 ng / ml). Increased vitamin D in the diet increased the number of red blood cell and, consequently, hemoglobin concentration in the blood (p <0.05) and decreased the number of white blood cell (p <0.05-0.01). In the blood of chickens that received high levels of vitamin D in the diet, more monocytes and neutrophils were detected. Particularly significant effects were observed for monocytes, the proportion of which in the blood of laying hens in group 2 increased by 1.2; and in laying hens of the third group - 1.6 times (p <0.01), compared to the laying hens of the 1st group. With an increase in the amount of vitamin D3 in the diet of leucocytes, the proportion of lymphocytes decreased, the content of which in laying hens of 1-, 2- and 3rd groups was 58.95, respectively; 54.57 and 48.26%. Under the influence of feeding 10.0 thousand IU / kg of vitamin D3 in the blood of hens, the phagocytic activity increased (p <0.05), which is consistent with the increase in the number of monocytes and neutrophils. The bactericidal activity of blood serum of laying hens of groups 2 and 3 (5.0 and 10.0 ths. IU / kg D3) was 20% higher (p <0.05) than in laying hens of group 1 (2, 5 thousand IU / kg D3). Thus, an increase in the diet of laying hens in vitamin D3 increases the innate imunity and does not stimulate a specific link.
Advances in Understanding the Pathogenesis: Bacterial Surface Glycans as The Virulence Factor and Role in Pathogen Bacteria
Authors: Ghazaei Ciamak , Amjad Soha
Published: August 2023

Bacterial glycans are essential components of bacterial walls and crucially important cell surface antigens such as lipopolysaccharide and polysaccharide capsules, which act as virulence-causing factors. Polysaccharide capsules in bacteria are naturally composed of recurring oligosaccharides and lipopolysaccharides. LPS is composed of domains that are hydrophobic in nature known as lipid A or endotoxin, which is a nonrepeating oligosaccharide "core", and an O-antigen. Interaction of glycan-receptor is critical in pattern recognition of microorganisms and regulatory signals that perform regular immune cell activities. The true glycan structure is important for collaboration with the immune system of host, as demonstrated by microorganisms that produce polycarbohydrates that mimic host particles in order to evade the immunity of host. Certain bacteria circumvent antibody defences by molecularly mimicking the glycan structures of host and masquerade as "self" to avoid identification by immune system. Phages are the most prevalent biological entities on our planet, and they evolved glycan-binding proteins (GBPs) to bind to bacterial glycans. These proteins are in charge of the breakdown of antibodies and are impervious to harsh conditions where bacteria live for example, the gut of mammals, water, and soil. In order to increase contact with bacterial glycans, the phages manufacture multimeric proteins.
Aerial Continuum Manipulation: A New Platform for Compliant Aerial Manipulation
Authors: Jalali Amir , Janabi-Sharifi Farrokh
Published: August 2023

Traditional aerial manipulation systems were usually composed of rigid-link manipulators attached to an aerial platform, arising several rigidity-related issues such as difficulties of reach, compliant motion, adaptability to object’s shape and pose uncertainties, and safety of human-manipulator interactions, especially in unstructured and confined environments. To address these issues, partially compliant manipulators, composed of rigid links and compliant/flexible joints, were proposed; however, they still suffer from insufficient dexterity and maneuverability. In this article, a new set of compliant aerial manipulators is suggested. For this purpose, the concept of aerial continuum manipulation system (ACMS) is introduced, several conceptual configurations are proposed, and the functionalities of ACMSs for different applications are discussed. Then, the performances of proposed aerial manipulators are compared with conventional aerial manipulators by implementing available benchmarks in the literature. To enhance the comparison, new features with related benchmarks are presented and used for evaluation purposes. In this study, the advantages of ACMSs over their rigid-link counterparts are illustrated and the potential applications of ACMSs are suggested. The open problems such as those related to dynamic coupling and control of ACMSs are also highlighted.
Privilege and Gendered Violence in the Canadian and British Houses of Commons: A Feminist Institutionalist Analysis
Authors: Raney Tracey , Collier Cheryl N.
Published: August 2023

The Canadian and British Houses of Commons have both recently adopted formal rules to address the problem of sexual misconduct in their parliaments. Using Feminist Institutionalism, we examine how these rules have been constrained or enabled by parliamentary privilege in both countries. As a result of their divergent historical approaches to privilege, we argue that the British House of Commons’ new rules are better suited to address this issue relative to its Canadian counterpart. This outcome has differential consequences for women and minorities who are the most vulnerable to abuse in each parliament.

 
Democratizing the Ontario Legislature: Change, but Change Enough?
Authors: Raney Tracey , Tregebov Sasha , Inwood Gregory J.
Published: August 2023

The Ontario Legislative Assembly sits at the centre of the many currents of political change in the province. Over the last few decades the three main political parties, the Progressive Conservative Party, the Liberal Party, and the New Democratic Party (NDP), has each formed a majority government at least once. In the 2011 provincial election, Ontarians voted for change again, albeit of a different kind: Dalton McGuinty’s Liberals were left one seat short of a majority, and Ontarians had elected their first minority government in a generation. In two by-elections in September 2012, Ontarians denied Premier McGuinty the opportunity to return to majority government. Just one month later, the Premier announced his resignation and prorogued (suspended) the legislature. 

These events raise questions about the democratic quality and evolving role of the Ontario Legislature. Amidst these changes, we ask: is Ontario’s legislature as democratic as it could be? This paper is organized around three key themes: the institutional features of the Ontario legislature, legislative processes, and political representation. We canvass various reforms and proposed changes in each thematic area and conclude with a discussion of the strengths and weaknesses of Ontario’s legislature as an instrument of democracy. We suggest that despite some reforms, the processes of making it more democratic remain unfinished. To this end, we also make several recommendations for improving the democratic quality of this central symbol of democracy in Ontario.
Green with rage: Women climate change leaders face online attacks
Authors: Raney Tracey , Gregory Mackenzie
Published: August 2023

Women leaders who support climate action are being attacked online with increasing regularity. These attacks should be viewed as a problem not only for the planet, but also to the goals of achieving gender equality and more inclusive, democratic politics.

Catherine McKenna, Canada’s environment and climate change minister, recently announced that she’s had to hire security to protect herself and her family while in public. With an election now on, it’s likely she’ll face further abuse in the weeks to come.

McKenna hired security after she was out with her children and a driver rolled down his window and shouted: “F-k you, Climate Barbie.” This sexist taunt was popularized by Conservative MP Gerry Ritz, who once used the slur in reference to McKenna on Twitter.

It resulted in a tsunami of #Climatebarbie hashtags and variations of the slur ever since. Ritz has since apologized and deleted the original tweet.
Harassment and violence are threats to local democracy; it’s time for Ontario to take them seriously
Authors: Raney Tracey
Published: August 2023

This fall Ontario voters will head to the polls again, this time to elect their municipal and school board leaders. Heading in to these elections, women councillors and municipal staffers have been speaking out about their experiences of sexism, harassment, and violence for some time.

The province needs to listen to them.
Addressing Violence and Harassment in Canada’s Senate: Critical Actors and Institutional Responses
Authors: Raney Tracey
Published: August 2023

The global movements of #MeToo, #TimesUp, and #BlackLivesMatter have brought the issues of gender and race-based violence into the public domain. The realm of politics is no exception. Over the last several years (and predating #MeToo), Canadian politicians and staffers at all levels of government and from all political stripes have faced sexism, racism, homophobia, harassment, and threats of violence from members of the public and from their colleagues. Since the 2019 federal election, this has included an armed trespasser apprehended on the grounds of Rideau Hall who made threats against Prime Minister Justin Trudeau, the vandalism of Minister Catherine McKenna’s constituency office window which was spray-painted with a vile, misogynistic word, and the street harassment of NDP leader Jagmeet Singh that was widely shared on social media. Although white, heterosexual, cisgender male politicians and staffers also experience violence, women, Black, Indigenous and persons of colour (BIPOC) and members of the LGBTQ+ community are disproportionately more likely to be on the receiving end of such acts and threats both on social media and in real life.