bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Formative Characteristics of the  written by Sojeon Son Jaehyeong
Authors:   The Korean Society of Calligraphy, Hyung Gye-soon
Published: May 2023

Sojeon Son Jaehyeong(素荃 孫在馨) is a representative calligrapher in the modern and contemporary Korean calligraphy field in the 20th century, as well as an educator, politician, collector, connoisseur, art administrator, etc. The contents of the  was composed on August 29, 1956, by Nosan Lee Eunsang in Hangeul mixed with classical Chinese characters, and Son Jaehyeong inscribed it with a brush. Son Jaehyeong's creativity in Hangeul calligraphy lies in applying the formativeness and calligraphic method of seal script, clerical script, regular script of the Tang Dynasty, and the school of learning from the stela of the Qing Dynasty to Hangeul calligraphy works. Son Jaehyeong searched for a creative way to apply the classical Chinese calligraphy style to the Hangeul calligraphy style, and his contribution to the history of modern and contemporary Korean calligraphy lies in that he opened up his world of calligraphy creation by breaking away from the level of imitating the old blindly. The character structure and disposition of the  are the best examples of this. It is a work that shows creativity that goes beyond conventional forms in the history of modern and contemporary Korean calligraphy. It also contains the beauty of Son Jaehyeong's unique modern formative sense, which he achieved through research on the traditional Hangeul calligraphy and obsession with the ancient methods of classical Chinese calligraphy. This beauty emerges concretely in terms of the formative features of taking the abnormality as the rightness(以奇爲正) and making the whole harmonious through the response of front and back strokes(救應圓融). The formative characteristics of taking the abnormality as the rightness developed into the aesthetics of seal script, clerical script, and regular script expressed in the character structure and disposition, and the features of making the whole harmonious through the response of before and after strokes transformed the formativeness and strokes of the ancient Hangeul calligraphic style into work with his individuality. In conclusion, I found that Son Jaehyeong's  contains the spirit of calligraphy aimed at creative fusion based on the aesthetic view of fusing various calligraphic styles.
The Nature of Beauty: Focusing on the aesthetic consciousness of Taoism
Authors:   The Korean Society of Calligraphy, Lee Sun-woo
Published: May 2023

This study examines the etymology of the concept of ”beauty“ to understand the nature of it, followed by the exploration on the new context and value of beauty based on literary materials that examines oriental aesthetic consciousness.
Oriental aesthetic consciousness has shifted from the Yin-Yang and the Five Elements theory of the Spring and Autumn period through Taoism and esthetical awareness of Confucianism, each representing art spirit and artification of human life, then to the 'Yi Jing psychology' which emphasizes subjectivity, desire, and pleasure. However, in the East, aesthetic pleasure was not perceived to originate from phenomena and forms. This was because the Holism perspective, which identifies the world as a whole, pursued after the invisible power 'Tao', that is, the essence of all forms and phenomena. In Confucianism, aesthetic consciousness was developed from a social and ethical perspective, and in Taoist philosophy, it was promoted from a naturalistic perspective through psychology and artistry. For this reason, Confucianism saw beauty in the essence of sublime human beings, focusing on the fundamental values of love of “benevolence” and “goodness”. And in Taoism, it aims for a more fundamental “Great beauty(大美)” and sees beauty in the world of the Tao, which is hidden behind all creations. In both Confucianism and Taoism, ‘Mi[beauty, 美]’ denied its relativity to 'Chu[ugliness, 醜]' in the phenomenon world and emphasized the vitality of the universe, and since then, it has tried to find out the reality of beauty by throwing aesthetic propositions such as ‘Ui[意]’, ‘Sang[象]’, and ‘Gyeong[境]’.
Everything in aesthetic consciousness is the manifestation of the mind that perceives, and the body of existence is only made up by the mind. Beauty is only one's own philosophical and aesthetic tendency created in the course of life, and it is the creative value of life given therefrom.
A Study on Zhèng Qiáo (鄭樵)’s Understanding of SeoHwa (書畵: Calligraphy and Painting) based on his Theory of SeoHwaDongChul (書畵同出: Calligraphy and painting are beginning from same root) in the Era of Song Dynasty
Authors:   The Korean Society of Calligraphy, Kim Eun-a
Published: May 2023

This article presents why Zhèng Qiáo understood the relation between Seo and Hwa focusing on graphonomy to raise the theory of SeoHwaDongChul. Zhāng Yàn Yuǎn (張彦遠)’s thoughts of SeoHwaDongChe (書畵同體: Calligraphy and painting are same as each other) led to the theory of SeoHwaDongChul suggested by Zhèng Qiáo in the era of Song dynasty. Zhèng Qiáo drew the meaning of DongChul of Seo and Hwa from graphonomy to develop his thoughts. The essences of his theory of SeoHwaDongChul investigated for this article are: First, YukSeo (六書: the theory of explaining about the formation of Chinese characters in six types) puts priority onto SangHyeong (象形: a type of formation of Chinese characters). He thought that YukSeo could not help putting such priority to Hyeong (形: shape) as literacy and language should be based on SangHyeong, painting. Hwa delivers Thao, and Seo and Hwa come out of same root, which itself means SeoHwaDongChul. Second, his theory of SeoHwaDongChul is based on I-Ching.
In particular, his thoughts of such show that he tried to explain about the origin, usage and formation of characters through the logic of I-Ching. Third, Doh (圖: picture or figure) shows whether academic goal has been achieved. which means the role and weight of Doh are big and heavy enough to contribute to establishing structure of a country. That is, the theory of SeHwaByengYong (書畫竝用: Seo and Hwa should be used together) is more for practice than for any other else. Fourth, Zhèng Qiáo’s theory of SeoHwaDongChul and Zhāng Yàn Yuǎn’s theory of SeoHwaDongChe look accord and same with each other. Such Zhèng Qiáo’s understanding of SeoHwa raised the role value of SeoHwa to an academic position and emphasized practicality of SeoHwa in academic boundary.
In conclusion, Zhèng Qiáo’s understanding that SeoHwa helps academic achievement and contribution to establishing structure of a country is an argument that SeoHwa plays the role as same as that of YukJeok (六籍: six Confucian classics) at artistry level.
A brief discussion on the relationship between the calm and elegant rhyme of Wang Xizhi's “kuaixueshiqingtie(快雪时晴帖)” and its calligraphy composition
Authors:   The Korean Society of Calligraphy, Luo Kun-Yu , Lee Jae-Woo
Published: May 2023

Wang Xizhi's law posts can be described as “one post, one appearance”, and “kuaixueshiqingtie” is a very special existence, revealing a kind of peace, no excitement, wind rules and regulations. Difference. “It's gratifying and stunned, one in the book”, calligraphy art is a form of art that reveals emotions. Why does this post show such a look? Let's discuss separately to seek rationally to spy the relationship between calligraphy techniques and emotions. Wang Xizhi's law posts can be described as “one post, one appearance”. Among them, “Fast Snow Shiqing Post” is a very special existence, revealing a kind of peace, no excitement, wind rules, and other laws. Huge difference. Calligraphy is an art form that expresss emotions. Han Yu has a saying: “It's gratifying and stunned, one is in the book”, why can “Fast Snow in the Snow” show this peaceful appearance. This article will use pen, structure, chapters, etc. The unique display form in the fast snowy post is discussed separately to seek rationally to spy the relationship between the form of calligraphy techniques and emotional expression. In the use of the pens, analyze the details of the collection, turning, and the weight changes, and expand the important connection of the form of the pen with the emotional performance; in the structural exposition Compared with Su Shi, Mi Yan, Wang Duo and others, the single -character structure can observe the characteristics of the stable structure in the “kuaixueshiqingtie”, which can discuss the relationship between the structure of the structure and emotion; In the discussion of the chapter research, the way to introduce axis can be revealed to the uniqueness of the seal of “kuaixueshiqingtie”, and the relationship between this method is found to form a relationship with its emotional performance.
王羲之诸法帖可谓“一帖一貌”，《快雪时晴帖》是一个非常特殊的存在，流露出一种平和自然、不激不厉、风规自远之貌，和其他法帖有很大的差异。“可喜可愕，一寓于书”，书法艺术是揭示情感的一种艺术形式，该帖为何呈现如此面貌，我们将用笔、结构、章法等在《快雪时晴帖》中的独特表现形式分开来论述，以求理性的窥探书法技法的表现和情感之间的关系。王羲之诸法帖可谓“一帖一貌”，其中《快雪时晴帖》是一个非常特殊的存在，流露出一种平和自然、不激不厉、风规自远之貌，和王羲之其他法帖有很大差异。书法是表达情感的艺术形式，韩愈有言：“可喜可愕，一寓于书”，《快雪时晴帖》为何能呈现出这种平和面貌，本文将通过用笔、结构、章法等在《快雪时晴帖》中的独特展现形式分开论述，以求理性的窥探书法技法形式和情感表达之间的关系。在用笔中将从起收笔、转折、轻重变化等细节进行分析，展开论述了用笔的形式与其情感表现的重要联系；在结构方面的论述中，将《快雪时晴帖》中的单字结构同苏轼、米芾、王铎等人对比研究，能较为直观的观察到《快雪时晴帖》中结构端稳平和的特点，进而可以论述结构构成与情感表达的关系；在对作品章法研究的探讨中，引入轴线图这一方式，可以把《快雪时晴帖》的章法独特性显现出来，找到这种章法构成与其情感表现之间的关系。
Integration of structural, hydrogeological and thermal remote sensing data for the determination of geothermal capacity A case study of the Edremit (Balıkesir) Basin
Authors: KAYADİBİ Önder , GÜRBOĞA Şule , AKILLI Hafize , ARIKAN Serap , TAN Sevilay , MUTLU Halim , DEVECİ ARAL Zehra
Published: May 2023

Basins formed on active strike-slip faults are important prospect areas for geothermal energy exploration since the crust gets thinner in these areas and tectonic structures provide favorable conditions for heat-fluid circulation and transport. The Edremit (Balıkesir) Basin holds a great promise for the discovery of new geothermal energy sources. The objective of the recent study is to evaluate the geothermal capacity of the Edremit Basin utilizing tectonic, geological, and hydrogeological studies, combining remote sensing (land surface temperature-LST, hydrothermal alteration, and multi-temporal InSAR (MT-InSAR) assessments). We present structural literature data and the results of field mapping, which revealed the geometry, kinematics, and dynamics of structural features, geological units as geothermal system components, thermal and cold water chemistry, and thermal infrared remote sensing analysis. For the purpose of assessing new targets and recent geothermal capacity, these data are combined and evaluated. According to the outcomes of the study, the fault pattern in the Edremit Basin is generated by N-S extension, which produced E-W dominant striking normal faults with a heritage of paleostructures oriented in various directions. According to remote sensing analyses, the primary LST regions in the basin are defined by the active faults. Therefore, a high sodium sulfate ratio recorded in the chemical analyses of the water samples indicates a deep circulation and high possibility for the presence of thermal water. Consequently, our findings are consistent with the work to include thorough field geology surveys, structural patterns, LST, and water chemistry to refined exploration process.
Protective role of 3-oxypyridine derivatives in rats’ steroid-induced osteoporosis associated with reduced oxidative stress and recovery of nitric oxide formation
Authors: Danilenko A. P. , Trunov K. S. , Pokrovsky M. V. , Danilenko L. M. , Korokin M. V. , Gudyrev O. S. , Khentov A. A. , Masalytina N. P. , Tatarenkova I. A. , Cherednichenko A. V. , Boeva E. V. , Koklin I. S. , Taran E. I.
Published: May 2023

From the point of view of the mechanisms for the implementation of pathogenetic links in the development of steroid-induced osteoporosis considered in the paper, the increased risk of the oxidative stress in osteoblasts, as well as the development of the vessels endothelial dysfunction of the microcirculatory bloodstream in the bone tissue, are of particular interest. They lead to the impaired bone tissue trophism and progression of osteoporosis.

The aim of the study was research of the osteoprotective effects of a 3-hydroxypyridine derivatives composition on the model of steroid-induced osteoporosis.

Materials and methods. To model osteoporosis pathology, the animals (male Wistar rats) were injected with methylprednisolone (MP) at the dose of 5 mg/kg (intraperitoneally) every 5th day for 5 weeks. Аs a non-selective blocker of NO synthase, L-NAME was used at the dose of 25 mg/kg (intraperitoneally). Derivatives of 3-hydroxypyridine (hereinafter referred to as composition No. 1) were administrated at the dose of 50 mg/kg (per os) In all experimental groups, the level of microcirculation and the bone mineral density, as well as the analysis of histomorphological and biochemical samples, were assessed.

Results. The study results showed that composition No. 1 (50 mg/kg) has an osteoprotective activity, effectively prevents a decrease in the level of the regional bone tissue microcirculation and in the development of an endothelial dysfunction. That makes it possible to increase the bone mineral density and to slow down the thinning of bone trabeculae. In addition, composition No. 1 (50 mg/kg) reduces the production of reactive oxygen species and increases the NO bioavailability.

Conclusion. The data obtained indicate that the studied composition of 3-hydroxypyridine derivatives is considered a promising compound for the prevention and treatment of steroid-induced osteoporosis.
Protocolo de Abordagem Diagnóstica e Terapêutica da Hipotensão Intracraniana Espontânea
Authors: Pinto Maria João , Braz Luís , Fonseca José , Pereira Paulo , Trigo Barbosa Paula , Gomes Armanda , Guimarães Joana
Published: May 2023

A hipotensão intracraniana espontânea (HIE) é uma síndrome caracterizada por cefaleia ortostática incapacitante, fruto de uma redução do volume de líquido cefalorraquidiano (LCR) provavelmente causada por uma fístula de LCR. Afeta sobretudo mulheres em idade ativa, estando provavelmente subdiagnosticada. Este protocolo visa apresentar uma proposta de abordagem prática ao diagnóstico e tratamento da HIE. Após uma secção descritiva das manifestações clínicas da HIE, apresentamos um modelo de atuação passo-a-passo para a confirmação do seu diagnóstico e tratamento, considerando diferentes cenários clínicos. Pretende-se, assim, facilitar a decisão clínica através de uma conduta sistematizada e individualizada, visando o melhor interesse do doente.
Individualization and contemporary fatherhood
Authors: Westerling Allan
Published: May 2023

Objective: This article explores dilemmas related to contemporary fatherhood and discusses how theories of individualization enable the understanding of social change and family life.
Background: Theories on modernization argue that ongoing processes of individualization challenge researchers to reinvent key concepts in family sociology. The concept of intimate fatherhood allows for the exploration of men’s family practices and presents a basis for understanding what modernization means for contemporary parenthood. Intimate fatherhood can be further theorized through empirically sensitive approaches in the study of everyday family life.
Method: Drawing on data from a mixed-method longitudinal study comprising four waves of data from the 1968 cohort in Denmark (n = 1,414), the study analyzes qualitative interviews from the second and fourth waves. Social psychological discourse analysis of the interviews is used to explore the participants' family practices.
Results: The analysis examines how caring intimacy in contemporary fatherhood is interwoven in a complex entanglement with other positions related to partnering and provision. Individualization is theorized as a mode of orientation in life with reference to oneself but not counterposed to social ties and family practices signified by solidarity and togetherness.
Conclusion: Individualization theory can guide analytical attention when examining contemporary fatherhood, but such analyses must remain sensitive to the complex entanglement of everyday family life.
A escola sem partido
Authors: Silva Genilson Ferreira da , Dutra Júnior Wagnervalter , Santos Wilson da Silva
Published: May 2023

Pretendemos analisar neste artigo, em nossa história do tempo presente, o Movimento Escola sem Partido (ESP), como sendo um fenômeno político advindo da experiência de recrudescimento de valores ultraconservadores, alimentado pela não punição dos principais agentes que sustentaram a ditadura civil militar por longos vinte e um anos. Para um maior entendimento do Movimento ESP, procuramos analisá-lo à luz do conceito de Estado Capitalista conservador e autoritário, de elementos neoliberais, dialogando, principalmente, com Nicos Poulantzas (2000, 2021) e Antônio Gramsci (1999, 2000). Nessa mesma direção de compreensão da ESP, preocupamo-nos em buscar a origem desse fenômeno e mostrar suas conexões com organismos conservadores e autoritários, e também com intelectuais, educadores, políticos e jornalistas que fazem eco com o reacionarismo. Atentamos, ainda, com o fito de melhor dissecar a ESP, para um entendimento dos aspectos atinentes ao conceito de Ideologia e Educação, evocando Marilena Chauí (2014), Theodor Adorno (2021), entre outros teóricos.
Pharmacological Effects of Glycyrrhiza glabra L. as Antihepatitis and Hepatoprotective for Children
Authors: Muslikh Faisal Akhmal , Priatna Puja Adi , Ekasari Wiwied
Published: May 2023

Background: The incidence of hepatitis in children has grown from the normal number of hepatitis cases since January 2022, and it will continue to rise since the etiology and pathophysiology are unknown. This case is distinct from those caused by the hepatitis A, B, C, D, and E viruses. Glycyrrhiza glabra L. is a medicinal herb that has long been used in medicine to treat respiratory, digestive, and immune system problems, but it is also known to have an inhibitory impact on the virus. Coronavirus-associated acute respiratory syndrome, hepatitis, herpes simplex virus, influenza virus. Objective: This article will look at Glycyrrhiza glabra L.'s antihepatitis and hepatoprotective properties. Methods: The Pubmed, Sage Journal, and Sciencedirect databases were searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards and the keywords "Glycyrrhiza glabra for hepatitis." The inclusion and exclusion criteria were followed. Results: From the search results, 17 publications were discovered that explain how Glycyrrhiza glabra L. can operate as an antihepatitis agent through anti-inflammatory, antiapoptotic, and hepatoprotective mechanisms. Conclusion: Glycyrrhiza glabra L. can be used as an anti-hepatitis and hepatoprotective in children at doses ranging from 240-480mg/kg/day.
Characteristics and Physical Stability of Nanoemulsion as a Vehicle for Anti-Aging Cosmetics: A Systematic Review
Authors: Rachman Eva Syariefah , Widji Soeratri  , Tristiana Erawati M
Published: May 2023

Background: Skin aging can be overcome by applying anti-aging cosmetics. Many active ingredients that have anti-aging potential are derived from plants, and these materials must be delivered with a sound skin delivery system, namely nanoemulsion. The characteristics of nanoemulsion are closely related to physical stability. Objective: This study aims to conduct a systematic review of in vivo and in vitro study designs to examine the characteristics and physical stability of nanoemulsions used in topical anti-aging cosmetics. Methods: A systematic literature review based on the PRISMA statement was used to review the articles regarding nanoemulsions’ characteristics and physical stability. The article search was accessed from an internet search database: Scopus, Pubmed, and Web of Science, published between January 2012 and June 2022. Results: Of the 244 articles, 44 were found to be related to the characteristics and physical stability of nanoemulsions in anti-aging cosmetics. These showed that active ingredients with antioxidant activity, filter UV rays, moisturizing agents, and cell-repairing agents are delivered by a nanoemulsion system with various types and ratios of surfactants, cosurfactants, and oil phases. Tween 80, Span 80, Transcutol HP, and Caprylic/capric triglyceride are the most widely used nanoemulsion compositions. Conclusion: The type and composition of the oil phase, surfactant, and cosurfactant affect the characteristics of the nanoemulsion (droplet size, polydispersity index, viscosity, zeta potential) and the physical stability of the nanoemulsion so that it can deliver active ingredients that have the potential as anti-aging well.
Clinical presentation, surgical treatment, and morphological diagnosis of paraurethral leiomyoma in women
Authors:   A.I.Burnasyan Medical and Biological University of Innovation and Continuing Education, Moscow, Russian Federation, Markosyan T.G. , Kondrashova L.M. ,   UNIM Laboratory, Moscow, Russian Federation, Kryichkov I.R. ,   UNIM Laboratory, Moscow, Russian Federation
Published: May 2023

This article presents a rare clinical case of non-epithelial tumor, a paraurethral leiomyoma, in a 44-year-old woman. The tumor was observed for a long time with an incorrect diagnosis of paraurethral cyst. The preoperative examination indicated a differential diagnosis between the paraurethral cyst, urethral diverticulum, and the neoplasm located on the anterior vaginal wall. The surgical intervention with tumor removal made it possible to make the correct diagnosis. The pathomorphological examination did not allow us to determine the nature of mesenchymal tumor definitively and unambiguously. The diagnosis of paraurethral leiomyoma was established only with a comprehensive immunohistochemical study with an extended range of markers. Key words: paraurethral leiomyoma, immunohistochemical study, spindle cell mesenchymal tumor
Outcome Comparison Between Insulin-Dependent and Non Insulin-Dependent Patients after Open Adult Cardiac Surgery
Authors: Kurniawaty Juni , Setianto Budi Yuli , Supomo Supomo , Widyastuti Yunita , Ancilla Cornelia , Boom Cindy Elfira
Published: May 2023

Background: Insulin-dependent diabetic patients usually have poor glycemic control and higher risk of complications than non-insulin-dependent diabetic patients. However, the difference in clinical outcomes between these two groups of patients who underwent open cardiac surgery was not established. Therefore, this study compares the short-term outcome of insulin vs non-insulin-dependent diabetic patients after open cardiac surgery in a large-scale study.

Methods: The study design was a retrospective cohort. All adults who underwent open cardiac surgery between January 1st 2016-December 31st 2020 in 4 tertiary hospitals in Indonesia were included in the study. From a total of 4.931 samples included in the study, 3.753 patients were non-diabetic (Group I) and 1.178 were diabetic (Group II). Group II was divided into subgroup IIA (930 non-insulin-dependent) and subgroup IIB (248 insulin-dependent). The main outcome was in-hospital mortality of open cardiac surgery patients.

Result: In-hospital mortality between group I and II had no significant difference (6.8% vs 5.7%; p = 0.188), as well as IIA and IIB (5.6% vs 6%; p = 0.782). Multivariate analysis demonstrated that diabetes did not increase mortality of open cardiac surgery (OR 0.665; p = 0.021). In-hospital mortality of subgroup IIB was higher than subgroup IIA, but insulin therapy did not increase the risk of in-hospital mortality (OR 1.259; p = 0.464).

Conclusion: Both insulin-dependent and non-insulin-dependent diabetes mellitus were not the predictors of poor short-term outcomes for open adult cardiac surgery patients.
REFLEKSI AKHIR TAHUN AKADEMISI UMSIDA 2021 Merekam Jejak Kebijaksanaan di Ujung Masa Pandemi
Authors:   Universitas Muhammadiyah Sidoarjo, Wahyuni Akhtim , Hindarto Hindarto , Kusuma Kumara Adji , Mursyidah Lailul , P Sri Budi , P Rifqi Ridlo
Published: May 2023

Rasanya sudah Lelah kita berjibaku dengan keadaan dengan covid 19 yang sudah 1 tahun setengah lebih ini menjadi musuh utama, namun demikian kita harus tetap waspada karena virus tersebut belum hilang. Tahun Pertama (2020) dirasa mencekam dan seluruh kebijakan digunakan untuk untuk menghambat laju virus, memasuki tahun ke dua (2021) memasuki masa dimana keaadan penuh ujian dan sesungguhnya awal babak baru di dunia kesehatan. Semua dipertaruhkan dengan segala problema yang ada. Anggaran besar besaran digunakan untuk menghadapi covid 19 ini. Berbagai macam kebijakan dilakukan termasuk diantaranya Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) (11-25 Januari) yang merupakan Instruksi dalam Negeri Nomor 1 Tahun2021.
RELIGIOUS MODERATION OF GENERATION Z: ATTITUDE OF STUDENTS’ RELIGIOUS TOLERANCE IN STRENGTHENING THE CHARACTER OF THE NATION
Authors: Rusli Rusdi , Ainah Noor , Arief Muhammad Ihsanul , Husin Gusti Muhammad Irhamna
Published: May 2023

The complex Indonesian society requires the residents to always maintain good relations to realize a harmonious life with each other. Peaceful and conflict are the potential two poles presenting in human life. Maintaining stable community conditions is a shared responsibility, from the government to the small community level. Besides, the level of the role of academics, especially students, becomes important as an object of research. Religious moderation is a wise attitude toward one's self during the conditions of a multicultural and multireligious society. Researchers focus on how the attitude of religious moderation in the form of tolerance of students representing generation Z, Universitas Lambung Mangkurat Banjarmasin, can be questioned. The students who are the object of their research are studying at FKIP, FK, and FEB. The results of research findings based on a standard of tolerance indicators that correspond to students’ response are more likely to be in an attitude of mutual respect, mutual help among each other, focus on equality, and always tolerance for all communities. In addition, the researchers classified the research findings based on the response of the answers on three categories of students: pluralist, inclusive, and exclusive. Potential attitudes tend to make students enter the pluralist category up to 53%. The type thus shows that students are more receptive to differences by supporting each other's good in the teachings of religions. Next, there are 41% enter the inclusive category. This category tends students to welcome differences in beliefs, but they still hold more of what is within the religions. The last category is exclusive, with 6% of the student classification results. This third catalog fully believes that goodness and truth are only in the person of his religion. Therefore, the three classifications' results show that Lambung Mangkurat University students tend to be more open to each other in the difference of beliefs. It will give positively impact on collaborative affairs in solving specific problems that need to be solved together, especially regarding the issues of this nation.
Laboratory Study for Biodegradation of Oxymatrine Insecticide by Single and Mixed Cultures of Fungi Isolated from Agriculture Soils in Basrah Governorate, Iraq
Authors: Et al. Raheem
Published: May 2023

This study focuses on the biodegradation of oxymatrine insecticide by some soil fungi isolated from four agriculture stations. The results showed that the highest degradation rate 94.66% was recorded by Ulocladium sp. at 10 days and A. niger recorded the lowest degradation rate 45.86%, while at 20 days Ulocladium sp. also showed the highest degradation rate 94.98% and the lowest degradation rate reached to 82.49% with A.niger. The mix (Exerohilum sp.+Ulocladium sp.) recorded the highest degradation rate of oxymatrine insecticide 90.22%, 88.51%, 85.34%  at 4, 8 and 12 ppm.The use of mixed isolates enhanced the biodegradation process. There is no study of oxymatrine biodegradation so this study is the first of its kind in the region which can be used as a baseline study for incoming studies
Experimental and Quantum Chemical Studies on the Corrosion Inhibition of Mild Steel By 2-((Thiophen-2-Ylmethylene) Amino)Benzenethio in 1M HCl
Authors: Mohammed Iman Mahdi
Published: May 2023

The impact of a Schiff base namely 2-((thiophen-2-ylmethylene)amino)benzenethiol  to corrode mild steel in 1 M HCl  resolved was evaluated using different weight loss technique and scanning electron microscopy (SEM).different weight measurements to expand that the 2-((thiophen-2-ylmethylene) amino) benzenethiol  inhibits  the corrosion of mild steel through adsorbing  of  top for mild steel and block the active locality. The inhibitive impacts of 2-((thiophen-2-ylmethylene)amino)benzenethiol  increase with increasing concentration and decrease with increasing temperature. SEM to checking revealed that the alloy surface was quite unaffected and formed protective film on its surface. The investigated inhibitor become as a shield for the mild steel surface from corrosive solution. Quantum chemical investigations corroborate experimental results well. The synthesized inhibitor was characterized employing NMR (nuclear magnetic resonance), FT-IR (Fourier-transform infrared) spectroscopies and CHN elemental analysis.
Alginate-chitosan hydrogels containing shRNA plasmid for inhibition of CTNNB1 expression in breast cancer cell
Authors: Cömez Birnur , Özbaş Suna
Published: May 2023

Objectives
The hydrogels prepared with alginate and chitosan polymers were aimed to deliver the shRNA-encoding plasmid (pshRNA) to MDA-MB-231 cells for the inhibition of β-catenin (CTNNB1) which was reported to be over-expressed in breast cancer.
Methods
Polyion complex hydrogels prepared using varying concentrations of sodium alginate and chitosan were characterized by Fourier transform infrared spectrometry (FTIR) analysis, swelling, and degradation properties. After the release properties and serum stability of pshRNA-loaded hydrogels were determined, their cytotoxicity, transfection efficacy, and effects on CTNNB1 expression were investigated in MDA-MB-231 cells.
Results
All hydrogels were shown to protect pshRNA from the enzymatic activity of serum and to deliver pshRNA to cells efficiently. As a result of transfection studies, pshRNA-loaded hydrogels reduced CTNNB1 expression by up to 30.25%. Cell viability also decreased by 38% in cells treated with 2.5% (w/v) alginate-chitosan hydrogel containing pshRNA targeting CTNNB1.
Conclusions
Alginate-chitosan hydrogels were shown to be a suitable matrix system for local gene delivery.
Season, weather and intraocular pressure: a monocentric retrospective analysis from 2016 - 2021
Authors: Wiedenmann Cornelius Jakob , Böhringer Daniel , Reinhard Thomas , Lübke Jan
Published: May 2023

BackgroundWe herein investigate the relationship between intraocular pressure (IOP) and environmental factors such as daily mean temperature, daily sunshine duration and daily mean atmospheric pressure.MethodsWe reviewed all IOP measurements of out-patients by non-contact tonometry that had been recorded between 2016 and 2021 (N = 199,804) in the Eye Center, University Hospital Freiburg, Germany. IOP values below 5 and above 30 mm Hg were excluded. No other exclusion criteria applied. Analysis of variance was performed to assess seasonal variations in IOP. We fitted a linear regression model to analyze the respective influences of age at time of measurement, daily mean temperature, daily sunshine duration and daily mean atmospheric pressure on IOP. We also performed cross-correlations to check for periodicity and time lag between IOP and the aforementioned environmental factors.ResultsIOP was highest in January (15.0 ± 3.8 mm Hg) and lowest in July (14.6 ± 3.6 mm Hg). Cross-correlation and Fourier analysis support annual periodicity and a seasonal pattern of IOP. Multiple linear regression revealed a significant negative correlation of daily mean temperature with IOP. Sunshine duration at the day of measurement did not correlate with IOP, but the total sunshine duration of the preceding ten days before measurement revealed a significant negative correlation. Atmospheric pressure missed statistical significance at multifactorial level.ConclusionsWe observed an annual periodic IOP variation with an amplitude of ≈ 0.4 mm Hg. The variation is most likely attributable to a direct effect of environmental temperature and secondly to biological factors triggered by sunshine exposure over the preceding ten days.
Template-based information transfer in chemically fueled dynamic combinatorial librar-ies
Authors: Kriebisch Christine , Burger Ludwig , Zozulia Oleksii , Stasi Michele , Floroni Alexander , Braun Dieter , Gerland Ulrich , Boekhoven Job
Published: May 2023

One of science’s greatest challenges is how life can spontaneously emerge from a mixture of abiotic molecules. A complicating factor is that life is inherently unstable, and, by extension, so are its molecules—RNA and proteins are prone to hydrolysis and denaturation. For the synthesis of life or to better understand its emergence at its origin, selection mechanisms are needed for such inherently unstable molecules. Here, we present a chemically-fueled dynamic combinatorial library as a model for RNA oligomerization and deoligomerization that shines new light on selection and purification mechanisms under kinetic control. In the experiments, nucleotide oligomers can only sustain by continuous production. We find that hybridization is a powerful tool for selecting unstable molecules as it offers feedback on oligomerization and deoligomerization rates. Template-based copying can thereby select molecules of specific lengths and sequences. Moreover, we find that templation can also be used to purify libraries of oligomers. Further, template-based copying within coacervate-based protocells changes its compartment’s physical properties, like their ability to fuse. Such reciprocal coupling between information sequences and physical properties is a key step toward synthetic life.
The Quantum Mechanical Computations of the Conformational, Structural, Electronic and Spectroscopic Properties of 3-Cyanophenylboronic Acide
Authors: UĞURLU Güventürk
Published: May 2023

In the present study, Conformational analysis of 3-cyanophenylboronic acid (3-CyBA) molecule have been carried by calculating potential energy surface (PES) as a function of two dihedral angles, C1-B-O1-H and C1-B-O2-H, using DFT/B3LYP/6-31G (d) level of theory. As a result of PES, molecular conformers corresponding to low energy of title molecule, anti-syn, syn-anti, syn-syn, anti-anti, respectively, have been determined according to the orientations of the hydroxyl groups attached to the boron atom. The geometries of anti-syn, syn-anti, syn-syn, anti-anti, conformers of studied molecule were fully optimized at the Hartree-Fock (HF) and DFT/B3LYP levels of the theory with 6-311++G(d,p) basis set, and compared with its crystal structure in the literature. The vibrational frequencies, infrared (FT-IR) intensities Raman (FT-Raman) scattering activities of all the conformers of the title molecule were calculated both methods, and vibrational assignments were performed by means of potential energy distribution (PED). Also, frontier molecular orbitals, the linear and nonlinear optics parameters, such as the polarizability (α) ground state dipole moment (µ) and the first-order hyperpolarizability (β) of 3-CyBA molecule, were calculated the same methods. The anti-syn conformer is found to be more stable than the syn-anti, syn-syn and anti-anti-conformers by 0.227, 1.078 and 4.577 kcal/mol in HF/6-311++G(d,p) and 0.248, 1.465 and 3.855 kcal/mol in DFT/B3LYP/6-311++G(d,p) level of theory, respectively. UV-visible absorption spectra such as excitation energies, absorption wavelengths (λ) and oscillator power (f) and stimulation contributions of all examined conformers were examined using TD-DFT/B3LYP and TD-HF methods, and transitions were determined.
Postpartum antihypertensive treatment - is there a correlation to placental lesions?
Authors: Kogan Zvia Fridman , Fridland Shir Nahum ,   Hadas Ganer Herman1, Miremberg Hadas , Bustan Mor , Schreiber Letizia , Kovo Michal
Published: May 2023

Objective: We aimed to examine the association of clinical risk factors and placental lesions, in gestations complicated with preeclampsia, with the need for antihypertensive treatment in the early postpartum period.
Methods: The computerized files and placental reports of all singleton deliveries at 24.0 - 42.0 weeks complicated by preeclampsia were reviewed between January 2013 and October 2020. Obstetric characteristics and placental lesions were compared between patients who required antihypertensive treatment in the early postpartum period and those who did not (control group). Placentas were classified into maternal and fetal malperfusion lesions and inflammatory responses.
Results: As compared to controls (n=200), the anti-hypertensive treatment group (n=95) was characterized by increased rates of preterm birth, preeclampsia with severe features, and cesarean delivery (p<0.001 for all). More placental hematomas (p=0.01 and placental maternal vascular lesions (p=0.03) were observed in the antihypertensive treatment group as compared to controls. In a logistic regression analysis, gestational age (OR 0.86, 95% CI 0.79-0.93, p=0.001) and preeclampsia with severe features (OR 8.89, 95% CI 3.18-14.93 p<0.001) were found to be independentlyassociated with the need for postpartum antihypertensive treatment.
Conclusion: Placental vascular lesions are more common in preeclamptic patients who need postpartum antihypertensive treatment, yet only early onset of preeclampsia with severe features was found to be independently associated with antihypertensive treatment in the early postpartum period.
Plasmon-ligand-mediated hydrogen evolution with visible light
Authors: Sa Jacinto , Dey Ananta , Mendalz Amal , Wach Anna , Vadell Robert , Silveira Vitor R. , Leidinger Paul Maurice , Huthwelker Thomas , Shtender Vitalii , Novotny Zbynek , Artiglia Luca
Published: May 2023

Plasmonic systems convert light into electrical charges and heat that mediate catalytic transformations. However, the debate about the involvement of hot carriers in the catalytic process remains shredded in controversy. Here, we demonstrate the direct use of plasmon hot electrons in the hydrogen evolution with visible light. A plasmonic nanohybrid system consisting of NiO/Au/[CoII(phen-NH2)2(H2O)2] (phen-NH2 = 1,10-Phenanthrolin-5-amine) that is unstable at water thermolysis temperatures was consciously assembled, ensuring that the plasmon contribution to the catalytic process is solely from hot carriers. With the combination of photoelectrocatalysis and advanced in situ spectroscopies, one could establish the reaction mechanism, which consisted of electron injection into the phenanthroline-ligands followed by two quick, concerted proton-coupled electron transfer steps resulting in the evolution of hydrogen. Light-driven hydrogen evolution with plasmons provides a sustainable route for producing green hydrogen, which modern society strives to achieve.
CMIP requirement in T Follicular helper cell highlights its role in the immunopathogenesis of Idiopathic Nephrotic Syndrome
Authors: Sahali Djillali , Savas Berkan , Ali Chloe Ben , Corsaut Gaelle , Vaineau Romain , Nasser Nour , Henique Carole , Zhang Shao-Yu , Chhuon Cerina , Guerrera Chiara , Pawlak Andre , Lafouresse Fanny , Graff-Dubois Stephanie , Audard Vincent , Ollero Mario
Published: May 2023

Follicular helper T (Tfh) cells are a specialized type of CD4 T-cell subset that support B cells during the germinal center (GC) reaction and determine the quality of the humoral response. Tfh development is a multistep process in which multiple extracellular and intracellular signals mediate CD4 T-cell differentiation, migration to lymphoid follicles and positioning in GC. Here we show that deletion of Cmip, an adaptor protein, in CD4 T cells prevents GC development and alters the humoral immune response after immunization. Deletion of Cmip shapes the differentiation of CD4 T cells toward a Th1 phenotype, while the Th2 and Tfh programs are inhibited. Cmip-deficient CD4 T cells display strong STAT5 activation and produce higher IL-2 both under resting conditions and after immunization, suggesting that Cmip deletion induces constitutive activation of the STAT5/IL-2 axis, while the Tfh program is inhibited at the early steps of differentiation. On the other hand, the frequency of Foxp3+CD4 T-cell subset is increased in Cmip-deficient mice. Collectively, these results suggest that Cmip is required for Tfh generation and inhibits Th1 and Treg differentiation. We found that CMIP is upregulated in circulating Tfh of patients with active idiopathic nephrotic syndrome and repressed in remission, pointing out the role of Tfh in the immunopathogenesis of the disease.
A New approach to assessing the accuracy of the LULC classification using Remote Sensing & GIS in Greater Mumbai, Maharashtra, India
Authors: Das Subhankar
Published: May 2023

This study focuses on developing an advanced accuracy assessment of supervised LULC-classified remote sensing images in the Greater Mumbai area. The commonly used Kappa index method was found to be problematic in terms of the accuracy of the assessment and interpretation of classified images. Therefore, this research aims to review the commonly used methods, such as the Pixel-based error, and create a new method, such as the unbiased area error matrix. The study also determines which method is better suited for assessing the quality of the classification. The new statistical method involves an unbiased area estimation error matrix that provides an overall assessment of the classification's accuracy, including the User’s accuracy, the Producer's accuracy, and a 95% confidence interval. The nature and magnitude of the errors, their source, and the reasons for errors within each class are identified for both the User’s and the Producer's accuracy. Comparing the unbiased area estimates error matrix to the traditional pixel-based error matrix, this study finds that the unbiased area matrix is more accurate for assessing image classification. Additionally, this paper suggests correcting the identified errors for further improvement in the classification.
Gene Polymorphism of KLF14 rs972283 and Its Association with Type 2 Diabetes Mellitus in the Egyptian patients
Authors: Ragab Halla M. , Maksoud Nabila Abd El , Amin Mona A. , Elaziz Wafaa Abd
Published: May 2023

Background: An extensive quest for genetic variables impacting the susceptibility for T2DM and other cardiometabolic disorders has been sparked by the global growth in the frequency of those widespread ailments. In Egypt, no previous studies examined the relation between KLF14 rs972283 SNP and the risk of developing T2DM. This study aims to ascertain the genetic influences of KLF14 rs972283 on T2DM in Egypt.
Subjects and methods: This study included 50 diabetic patients and 50 healthy subjects. Each individual underwent a clinical assessment and total body examination, laboratory investigations including liver enzymes, FBS, HbA1C, and lipid profile. The DNA Purification Kit was used to separate genomic DNA from the whole blood. Gene polymorphism was detected via the PCR-REFLP method.
Results: There was no association between KLF14 (rs972283) gene polymorphism and T2DM among studied people. The distribution of KLF14 rs972283 genotypes in diabetic cases was 9 patients with GG genotype (18%) and 26 with GA (52%) while 15 patients (30%) had homozygous mutant genotype AA. However, in the control group, 7 healthy cases had the GG genotype (14%), 31 (62%) had the GA genotypes, and 12 (24%) had the AA genotype. Concerning the allele frequency, the A allele in the KLF14 rs972283 polymorphism was more frequent in both diabetic and control cases (56% and 55%; respectively), but without significant difference (P=0.887).
Conclusion: The present study shows for the first time that rs972283 SNP of the KLF14 gene was not associated with T2DM susceptibility in the Egyptian population. However, this study detects an association between KLF14 rs972283 (GG genotype) and a higher risk for elevated TG and LDL levels in control cases. This could indicate that the presence of the GG genotype even in control cases could be used to predict cardiovascular disease.
Sexual and reproductive health for women who live with inflammatory bowel disease:
Authors: O'Reilly Kate , Holroyd Eleanor , McInnes Susan , Peters Kath
Published: May 2023

Purpose To provide an understanding of the sexual and reproductive health issues for women who live with Inflammatory Bowel Disease.Methods Databases searched in this integrative review included: CINAHL Plus, Google Scholar, SCOPUS and Web of Science databases. A defined research aim guided the search strategy and facilitated the accurate extraction of data from primary qualitative and quantitative research conducted between 2012 and 2022.Results 19 papers were included in this review. All papers were appraised using the Mixed Methods Appraisal Tool (MMAT) [1] and were found to be of good methodological quality. The following three themes were identified: 1) Inflammatory Bowel Disease negatively impacts sexual, reproductive and social health; 2) Inflammatory Bowel Disease and sexual functioning; 3) Reproductive knowledge and reservedness to discuss sexual health.Conclusion This review of the literature highlights that sexual and reproductive health issues for women who live with inflammatory bowel disease are very focused on sexual dysfunction and reproduction. The review illuminates that there is a dearth of information which explores women’s sexuality more broadly.
Tamoxifen in association with titanium lowers vitality but does not change collagen synthesis and mineralization rates in SAOS-2 cells
Authors: Fiorin Luiz Guilherme , Galliera Emanuela , Matheus Henrique Rinaldi , Henin Dolaji , Souza Francisley Ávila , Almeida Juliano Milanezi , Dellavia Claudia
Published: May 2023

The aim of this study was to observe the influence of tamoxifen associated with titanium implants on the viability and metabolism of human osteosarcoma (SAOS-2) cells lines, as well as on their collagen production and mineralizing capacity. SAOS-2 cells were incubated with growth medium Dulbecco’s modified Eagle’s medium (DMEM) at 37°C, in an atmosphere containing 5% CO2. The samples were divided into groups that included the presence/absence of tamoxifen and the /not use of titanium disks alone and in combination. A total of 54 Titanium (Ti) disks were manufactured. The disks went through sandblasting, cleaning, plasma decontamination and further sterilization. Tamoxifen was used in concentration of 2 µM. Cells vitality, metabolism, mineralization, and collagen rates were assessed. The rate of collagen synthesis and mineralization was calculated with respect to a negative control. Tamoxifen and titanium alone caused a decrease in SAOS-2 cell line vitality, metabolism, collagen synthesis and collagen rate. When in association TAM and Ti caused a slightly decrease in vitality but not in the metabolism, collagen synthesis and mineralization rates. Based on our findings, it appears that the combination of tamoxifen and titanium implants may activate a pathway that promotes metabolism homeostasis, collagen synthesis and mineralization rates.