bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure of Silk I (Bombyx mori Silk Fibroin before Spinning) -Type II β-Turn, Not α-Helix-
Authors: Asakura Tetsuo
Published: June 2021

Recently, considerable attention has been paid to Bombyx mori silk fibroin by a range of scientists from polymer chemists to biomaterial researchers because it has excellent physical properties, such as strength, toughness, and biocompatibility. These appealing physical properties originate from the silk fibroin structure, and therefore, structural determinations of silk fibroin before (silk I) and after (silk II) spinning are a key to make wider applications of silk. There are discrepancies about the silk I structural model, i.e., one is type II β-turn structure determined using many solid-state and solution NMR spectroscopies together with selectively stable isotope-labeled model peptides, but another is α-helix or partially α-helix structure speculated using IR and Raman methods. In this review, firstly, the process that led to type II β-turn structure by the authors was introduced in detail. Then the problems in speculating silk I structure by IR and Raman methods were pointed out together with the problem in the assignment of the amide I band in the spectra. It has been emphasized that the conformational analyses of proteins and peptides from IR and Raman studies are not straightforward and should be very careful when the proteins contain β-turn structure using many experimental data by Vass et al. In conclusion, the author emphasized here that silk I structure should be type II β-turn, not α-helix.
First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?
Authors: Mignani Serge , Bignon Jérôme , Shi Xiangyang , Majoral Jean-Pierre
Published: June 2021

Based on phenotypic screening, the major advantages of phosphorus dendrimers and dendrons as drugs allowed the discovery of new therapeutic applications, for instance, as anti-cancer and anti-tuberculosis agents. These biological activities depend on the nature of the chemical groups (neutral or cationic) on their surface as well as their generation. As lessons to learn, in the oncology domain, the increase in the generation of metallo-dendrimers is in the same direction as the anti-proliferative activities, in contrast to the development of polycationic dendrimers, where the most potent anti-tuberculosis phosphorus dendrimer was observed to have the lowest generation (G0). The examples presented in this original analysis of phosphorus dendrimers and dendrons provide support for the lessons learned and for the development of new nanoparticles in nanomedicine.
Improved Photoelectrochemical Performance of MoS2 through Morphology-Controlled Chemical Vapor Deposition Growth on Graphene
Authors: Seo Dong-Bum , Trung Tran , Bae Sung-Su , Kim Eui-Tae
Published: June 2021

The morphology of MoS2 nanostructures was manipulated from thin films to vertically aligned few-layer nanosheets on graphene, in a controllable and practical manner, using metalorganic chemical vapor deposition. The effects of graphene layer and MoS2 morphology on photoelectrochemical (PEC) performance were systematically studied on the basis of electronic structure and transitions, carrier dynamic behavior, and PEC measurements. The heterojunction quality of the graphene/vertical few-layer MoS2 nanosheets was ensured by low-temperature growth at 250−300 °C, resulting in significantly improved charge transfer properties. As a result, the PEC photocurrent density and photoconversion efficiency of the few-layer MoS2 nanosheets significantly increased upon the insertion of a graphene layer. Among the graphene/MoS2 samples, the few-layer MoS2 nanosheet samples exhibited shorter carrier lifetimes and smaller charge transfer resistances than the thin film samples, suggesting that vertically aligned nanosheets provide highly conductive edges as an efficient pathway for photo-generated carriers and have better electronic contact with graphene. In addition, the height of vertical MoS2 nanosheets on graphene should be controlled within the carrier diffusion length (~200 nm) to achieve the optimal PEC performance. These results can be utilized effectively to exploit the full potential of two-dimensional MoS2 for various PEC applications.
Ketogenic Dietary Therapies in Patients with Autism Spectrum Disorder: Facts or Fads? A Scoping Review and a Proposal for a Shared Protocol
Authors: Varesio Costanza , Grumi Serena , Zanaboni Martina Paola , Mensi Martina Maria , Chiappedi Matteo , Pasca Ludovica , Ferraris Cinzia , Tagliabue Anna , Borgatti Renato , De Giorgis Valentina
Published: June 2021

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with increasing incidence. An expanding body of literature is examining connections between ASD and dietary interventions. Existing reports suggest a beneficial effect of ketogenic dietary therapies (KDTs) in improving behavioral symptoms in ASD. In this context, the purpose of this scoping review was to identify and map available evidence in the literature about the feasibility and potential efficacy of KDTs in pediatric patients with ASD and to inform clinical practice in the field. Moreover, based on the resulting data from the literature review, we aimed to provide a shared protocol to develop a personalized KDT intervention in patients with ASD. A comprehensive and structured web-based literature search was performed using PubMed and Scopus and it yielded 203 records. Seven papers were finally selected and included in the review. Data were abstracted by independent coders. High variability was identified in study designs and dietary aspects emerged among selected studies. Results supported the effectiveness of KDTs in promoting behavioral improvements. Clinical recommendations on which patients may benefit most from KDTs implementation and difficulties in dietary adherence were discussed.
Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats
Authors: Sierra-Cruz Marta , Miguéns-Gómez Alba , Grau-Bové Carme , Rodríguez-Gallego Esther , Blay Mayte , Pinent Montserrat , Ardévol Anna , Terra Ximena , Beltrán-Debón Raúl
Published: June 2021

Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.
COVID Obesity: A One-Year Narrative Review
Authors: Ovalle Diana L. Palacios , Rodrigo-Cano Susana , González Aránzazu , Soler Carla , Catalá-Gregori Ana I. , Merino-Torres J. Francisco , Soriano Jose M.
Published: June 2021

On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). This study focuses on a narrative review about the illness during the first year of the pandemic in relation to obesity. Databases were used to search studies published up to 8 December 2020. In total, 4430 articles and other scientific literature were found, and 24 articles were included in this one-year narrative review. The mean BMI value of severe COVID-19 patients ranged from 24.5 to 33.4 kg/m2, versus <18.5 to 24.3 kg/m2 for non-severe patients. Articles using the terms obesity or overweight without indicating the BMI value in these patients were common, but this is not useful, as the anthropometric parameters, when not defined by this index, are confusing due to the classification being different in the West compared to among Asian and Korean criteria-based adults. We proposed a new term, called COVID obesity, to define the importance of this anthropometric parameter, among others, in relation with this pandemic.
The Role of Dishware Size in the Perception of Portion Size in Children and Adolescents with Obesity
Authors: Dörsam Annica Franziska , Weiland Alisa , Sauer Helene , Giel Katrin Elisabeth , Stroebele-Benschop Nanette , Zipfel Stephan , Enck Paul , Mack Isabelle
Published: June 2021

Purpose: The influence of dishware on portion size perception in children and adolescents is inconclusive. This study investigated how children and adolescents with both obesity and a normal weight perceived portion size in different sized and shaped dishware items. Methods: The study included 60 children and adolescents with overweight and obesity (OBE) and 27 children and adolescents with normal weight (NW) aged from 9 to 17 years. The participants estimated quantities in three pairs of drinking glasses, one pair of bowls and two pairs of plates which varied in size and shape. The children were instructed to state intuitively which portion they would choose for big or small thirst/hunger. Thereafter they were asked to determine the exact amount by answering which dishware item contained the larger/smaller portion (cognitive evaluation). Results: There were no substantial differences in the intuitive evaluation of portion sizes between OBE and NW. During the cognitive evaluation, OBE estimated the amount of water in the glasses more correctly compared to NW (61% vs. 43%; p = 0.008); OBE estimated the amount of lentils in the bowls and on the plates significantly less correctly (39%) compared to NW (56%; p = 0.013). Conclusions: Habit formation and environmental stimuli might play a greater role in estimating food amounts in dishware than the child’s and adolescent’s body weight.
The Effect of Mediterranean Diet on Cognitive Functions in the Elderly Population
Authors: Klimova Blanka , Novotny Michal , Schlegel Petr , Valis Martin
Published: June 2021

At present, due to the demographic changes and the rise of senior population worldwide, there is effort to prolong an active life of these people by both pharmacological and non-pharmacological strategies. The purpose of this article is, on the basis of the literature review of recent clinical studies, to discuss one of such strategy, i.e., the effect of Mediterranean Diet (MedDiet) on the cognitive functions among both the cognitively unimpaired and impaired elderly people. The methodology includes a literature review of full-text, peer-reviewed journal studies written in English and published in Web of Science and PubMed between 1 January 2016 and 28 February 2021. The findings indicate that the adherence to MedDiet has a positive effect on both cognitively impaired and unimpaired older population, especially on their memory, both in the short and long run. The results show that the higher adherence to MedDiet proves to have a better effect on global cognitive performance of older people. In addition, the adherence to MedDiet offers other benefits to older people, such as reduction of depressive symptoms, lowered frailty, as well as reduced length of hospital stays.
Effect of Glutamine Supplementation on Muscular Damage Biomarkers in Professional Basketball Players
Authors: Córdova-Martínez Alfredo , Caballero-García Alberto , Bello Hugo J , Pérez-Valdecantos Daniel , Roche Enrique
Published: June 2021

Scientific evidence supports the role of L-glutamine in improving immune function. This could suggest a possible role of L-glutamine in recovery after intense exercise. To this end, the present report aimed to study if oral L-glutamine supplementation could attenuate muscle damage in a group of players of a mainly eccentric sport discipline such as basketball. Participants (n = 12) were supplemented with 6 g/day of glutamine (G group) or placebo (P group) for 40 days in a crossover study design (20 days with glutamine + 20 days with placebo and vice versa). Blood samples were obtained at the beginning and at the end of each period and markers from exercise-induced muscle damage were determined. The glutamine supplemented group displayed significantly low values of aspartate transaminase, creatine kinase and myoglobin in blood, suggesting less muscle damage compared to the placebo. In addition, adrenocorticotropic hormone levels were lower in the glutamine supplemented group than in the placebo. As a result, the circulating cortisol levels did not increase at the end of the study in the glutamine supplemented group. Altogether, the results indicate that glutamine could help attenuate exercise-induced muscle damage in sport disciplines with predominantly eccentric actions.
A Dynamic Analysis of the Demand for Health Care in Post-Apartheid South Africa
Authors: Mhlanga David
Published: June 2021

The study aimed to investigate the drivers of demand for healthcare in South Africa 26 years after democracy. The pattern healthcare demand by households in South Africa is that most households use public healthcare services particularly public clinics compared to private and traditional healthcare facilities. Using conditional probability models, the logit model to be more specific, the results revealed that households head who is unemployed, households who do not have a business, households who were not receiving pension money, had a greater probability of demand for public healthcare institutions. On the other hand, being male, being White, Indian and Coloured, being a property owner and being not a grant beneficiary, reduces the probability of demand for public healthcare facilities in South Africa. As a result, the study recommends more investment in public healthcare but more in public clinics in South Africa due to the high percentage of households using these services. Also, the government must consider investing more in the maintenance and improvement of the welfare of nurses in the country considering the huge role they play in the delivery of healthcare to the citizens.
Whole-Genome Sequencing for Tracing the Genetic Diversity of Brucella abortus and Brucella melitensis Isolated from Livestock in Egypt
Authors: Khan Aman , Melzer Falk , Sayour Ashraf , Shell Waleed , Linde Jörg , Abdel-Glil Mostafa , El-Soally Sherif , Elschner Mandy , Sayour Hossam , Ramadan Eman , Mohamed Shereen , Hendam Ashraf , Ismail Rania , Farahat Lubna , Roesler Uwe , Neubauer Heinrich , El-Adawy Hosny
Published: June 2021

Brucellosis is a highly contagious zoonosis that occurs worldwide. Whole-genome sequencing (WGS) has become a widely accepted molecular typing method for outbreak tracing and genomic epidemiology of brucellosis. Twenty-nine Brucella spp. (eight B. abortus biovar 1 and 21 B. melitensis biovar 3) were isolated from lymph nodes, milk, and fetal abomasal contents of infected cattle, buffaloes, sheep, and goats originating from nine districts in Egypt. The isolates were identified by microbiological methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Differentiation and genotyping were confirmed using multiplex PCR. Illumina MiSeq® was used to sequence the 29 Brucella isolates. Using MLST typing, ST11 and ST1 were identified among B. melitensis and B. abortus, respectively. Brucella abortus and B. melitensis isolates were divided into two main clusters (clusters 1 and 2) containing two and nine distinct genotypes by core-genome SNP analysis, respectively. The genotypes were irregularly distributed over time and space in the study area. Both Egyptian B. abortus and B. melitensis isolates proved to be genomically unique upon comparison with publicly available sequencing from strains of neighboring Mediterranean, African, and Asian countries. The antimicrobial resistance mechanism caused by mutations in rpoB, gyrA, and gyrB genes associated with rifampicin and ciprofloxacin resistance were identified. To the best of our knowledge, this is the first study investigating the epidemiology of Brucella isolates from livestock belonging to different localities in Egypt based on whole genome analysis.
Fabrication and Characterization of Fast-Dissolving Films Containing Escitalopram/Quetiapine for the Treatment of Major Depressive Disorder
Authors: Alkahtani Manal E. , Aodah Alhassan H. , Abu Asab Omar A. , Basit Abdul W. , Orlu Mine , Tawfik Essam A.
Published: June 2021

Major depressive disorder (MMD) is a leading cause of disability worldwide. Approximately one-third of patients with MDD fail to achieve response or remission leading to treatment-resistant depression (TRD). One of the psychopharmacological strategies to overcome TRD is using a combination of an antipsychotic as an augmenting agent with selective serotonin reuptake inhibitors (SSRIs). Among which, an atypical antipsychotic, quetiapine (QUE), and an SSRI, escitalopram (ESC), were formulated as a fixed-dose combination as a fast-dissolving film by coaxial electrospinning. The resultant fiber’s morphology was studied. SEM images showed that the drug-loaded fibers were smooth, un-beaded, and non-porous with a fiber diameter of 0.9 ± 0.1 µm, while the TEM images illustrated the distinctive layers of the core and shell, confirming the successful preparation of these fibers. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies confirmed that both drugs were amorphously distributed within the drug-loaded fibers. The drug-loaded fibers exhibited a disintegration time of 2 s, which accelerated the release of both drugs (50% after 5 min) making it an attractive formulation for oral mucosal delivery. The ex vivo permeability study demonstrated that QUE was permeated through the buccal membrane, but not ESC that might be hindered by the buccal epithelium and the intercellular lipids. Overall, the developed coaxial fibers could be a potential buccal dosage form that could be attributed to higher acceptability and adherence among vulnerable patients, particularly mentally ill patients.
Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery
Authors: Moya Elisa L. J. , Vandenhaute Elodie , Rizzi Eleonora , Boucau Marie-Christine , Hachani Johan , Maubon Nathalie , Gosselet Fabien , Dehouck Marie-Pierre
Published: June 2021

Central nervous system (CNS) diseases are one of the top causes of death worldwide. As there is a difficulty of drug penetration into the brain due to the blood–brain barrier (BBB), many CNS drugs treatments fail in clinical trials. Hence, there is a need to develop effective CNS drugs following strategies for delivery to the brain by better selecting them as early as possible during the drug discovery process. The use of in vitro BBB models has proved useful to evaluate the impact of drugs/compounds toxicity, BBB permeation rates and molecular transport mechanisms within the brain cells in academic research and early-stage drug discovery. However, these studies that require biological material (animal brain or human cells) are time-consuming and involve costly amounts of materials and plastic wastes due to the format of the models. Hence, to adapt to the high yields needed in early-stage drug discoveries for compound screenings, a patented well-established human in vitro BBB model was miniaturized and automated into a 96-well format. This replicate met all the BBB model reliability criteria to get predictive results, allowing a significant reduction in biological materials, waste and a higher screening capacity for being extensively used during early-stage drug discovery studies.
The Effect of a Triple Combination of Bevacizumab, Sodium Hyaluronate and a Collagen Matrix Implant in a Trabeculectomy Animal Model
Authors: Andrés-Guerrero Vanessa , Camacho-Bosca Irene , Salazar-Quiñones Liseth , Ventura-Abreu Nestor , Molero-Senosiain Mercedes , Hernández-Ruiz Samuel , Bernal-Sancho Guillermo , Herrero-Vanrell Rocío , García-Feijóo Julián
Published: June 2021

Currently available anti-scarring treatments for glaucoma filtration surgery (GFS) have potentially blinding complications, so there is a need for alternative and safer agents. The effects of the intrableb administration of a new combination of the anti-VEGF bevacizumab, sodium hyaluronate and a collagen matrix implant were investigated in a rabbit model of GFS, with the purpose of modulating inflammation, angiogenesis, fibroblast migration and fibrogenesis in the wound healing process. A comparative-effectiveness study was performed with twenty-four rabbits, randomly assigned to the following treatments: (a) biodegradable collagen matrix implant (Olo), (b) bevacizumab-loaded collagen matrix implant (Olo-BVZ), (c) bevacizumab-loaded collagen matrix implant combined with sodium hyaluronate (Olo-BVZ-H5) and (d) sham-operated animals (control). Rabbits underwent a conventional trabeculectomy and were studied over 30 days in terms of intraocular pressure and bleb characterization (height, area and vascularity in central, peripheral and non-bleb zones). Histologic differences among groups were further evaluated at day 30 (inflammation, total cellularity and degree of fibrosis in the area of surgery). Local delivery of bevacizumab (Olo-BVZ and Olo-BVZ-H5) increased the survival of the filtering bleb by 21% and 31%, respectively, and generated a significant decrease in inflammation and cell infiltration histologically 30 days after surgery, without exhibiting any local toxic effects. Olo-BVZ-H5 showed less lymphocyte infiltration and inflammation than the rest of the treatments. Intraoperative intrableb implantation of bevacizumab, sodium hyaluronate and a collagen matrix may provide an improved trabeculectomy outcome in this model of intense wound healing. This study showed an effective procedure with few surgical complications and a novel combination of active compounds that offer new possibilities to improve the efficacy of filtration surgery.
Modulation of Urate Transport by Drugs
Authors: Tátrai Péter , Erdő Franciska , Dörnyei Gabriella , Krajcsi Péter
Published: June 2021

Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations. Transporters play crucial roles in urate disposition, and drugs that interact with urate transporters either by intention or by accident may modulate SU levels. We examined whether in vitro transporter interaction studies may clarify and predict such effects. Methods: Transporter interaction profiles of clinically proven urate-lowering (uricosuric) and hyperuricemic drugs were compiled from the literature, and the predictive value of in vitro-derived cut-offs like Cmax/IC50 on the in vivo outcome (clinically relevant decrease or increase of SU) was assessed. Results: Interaction with the major reabsorptive urate transporter URAT1 appears to be dominant over interactions with secretory transporters in determining the net effect of a drug on SU levels. In vitro inhibition interpreted using the recommended cut-offs is useful at predicting the clinical outcome. Conclusions: In vitro safety assessments regarding urate transport should be done early in drug development to identify candidates at risk of causing major imbalances. Attention should be paid both to the inhibition of secretory transporters and inhibition or trans-stimulation of reabsorptive transporters, especially URAT1.
Peer Teaching in an Interprofessional Education Activity Focused on Professional Skills Development
Authors: DelNero Tracey , Vyas Deepti
Published: June 2021

The purpose of this study was to assess the impact of a peer-taught interprofessional education (IPE) activity on pharmacy and physician assistant (PA) student self-assessed confidence and attitudes related to professional skills. First-year pharmacy (n = 210) and PA (n = 45) students participated in a two-hour IPE activity. Forty-five teams consisting of one PA and at least four pharmacy students completed three peer-teaching stations focused on diabetes device education, pulmonary device teaching/case workup, and physical assessment skills. Students completed a pre- and post-activity confidence survey and a post-activity attitudes survey. For pharmacy students, highest confidence gains were noted on the items related to performing a physical exam. For PA students, largest gains were noted on the items related to insulin delivery systems. Eighty-three percent of students either agreed or strongly agreed with the statement “I learned things during this IPE activity that I will implement in clinical practice.” Seventy six percent of students felt that the physical assessment station was “beneficial or very beneficial” to their learning. A vast majority of students noted the IPE activity “somewhat or definitely” enhanced their communication with other health professionals and promoted a climate of mutual respect. In conclusion, peer teaching improved student attitudes and confidence.
Study of the Biologically Active Properties of Medicinal Plant Cotinus coggygria
Authors: Sukhikh Stanislav , Noskova Svetlana , Pungin Artem , Ivanova Svetlana , Skrypnik Liubov , Chupakhin Evgeny , Babich Olga
Published: June 2021

The results of the studies have shown that to obtain an extract of a complex of biologically active substances of Cotinus coggygria, ethyl alcohol (mass fraction of alcohol 70%) with a hydromodule of 1:5 should be used, and the extraction should be carried out for 60 min at a temperature of 60 °C. The investigated plant extracts with the complex of bioactive substances from the Cotinus coggygria leaves and flowers are safe from the point of view of the content of heavy metals, pesticides, aflatoxin B1, radionuclides, as well as pathogenic and opportunistic microorganisms. It has been established that the Cotinus coggygria extract contains rutin, hyperoside, ferulic acid, quercetin, kaempferol, disulphuretin, sulphurein, sulphurein, gallic acid, methyl gallate, pentagalloyl glucose, 3,3′,4′,5,6,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3-O-α-L-rhamnofuranoside, 3,3′,4′,5,5′,7-hexahydroxyflavulium(1+), 7-O-β-D glucopyranoside, and 3,3′,4′,7-tetrahydroxyflavonone. The tested extracts have anticancer, antigenotoxic, and antimicrobial (against E. coli, S. aureus, P. vulgaris, C. albicans, L. mesenteroides) properties. The high antioxidant status of the tested extracts was established; the antioxidant activity of the samples was 145.09 mg AA/g (AA—ascorbic acid).
The importance of Structural and Functional Analysis of Extracts in Plants
Authors: Lamponi Stefania
Published: June 2021

Plants and their extracts have traditionally been used against various pathologies and in some regions are the only therapeutic source for the treatment and prevention of many chronic diseases [...]
Fractionation and Distribution of Rare Earth Elements in Marine Sediment and Bioavailability in Avicennia marina in Central Red Sea Mangrove Ecosystems
Authors: Alhassan Abdullahi , Aljahdali Mohammed
Published: June 2021

Rare earth element fractionation and distribution in the coastal ecosystem have been of significant concern and are recognized worldwide as emerging micro-pollutants. However, unlike other metals such as trace elements, little is known about their uptake by aquatic plants such as the mangrove Avicennia marina, especially in the central Red Sea. We investigated the fractionation of rare earth elements in six mangrove ecosystems in the central Red Sea and bioavailability in mangrove A. marina. The concentrations of rare earth elements, sediment grain sizes, multi-elemental ratios, geo-accumulation index (Igeo) and bioconcentration factor (BCF) vary significantly (p < 0.05) across the six mangrove ecosystems. Higher concentrations of rare earth elements were recorded at Al Lith (LT) (101.53 mg/kg) and South Jeddah (SJ) (73.38 mg/kg) mangrove ecosystems. However, multi-elemental ratio R(M/L) reveals positive values. In contrast, multi-elemental ratio R(H/M) reveals negative values corresponding to fractionation patterns enriched with medium rare earth elements and heavy rare earth elements depletion across the six mangrove ecosystems. BCF values for rare earth elements were <1, but Lutetium (0.32) had the highest BCF among the rare earth elements, suggesting an efficient accumulation of Lutetium than any other rare earth elements. The scale of Igeo revealed strong contamination (4 ≤ Igeo ≥ 5) of sediment with Lanthanum, Cerium, Praseodynium, Samarium, Godolinium, Holmium, Erbium, Ytterbium, and moderate contamination with Thulium, Terbium, and Dysprosium (1 ≤ Igeo ≤ 3). Principal component analysis showed that clay silt sediment grain size influences rare earth element concentrations in the central Red Sea. Our results provide new evidence for rare earth element fractionation and accumulation in sediment and the potential use of mangrove A. marina for rare earth element monitoring in mangrove ecosystems in the central Red Sea.
Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic
Authors: Verano Naranjo Lidia , Cejudo Bastante Cristina , Casas Cardoso Lourdes , Mantell Serrano Casimiro , Martínez de la Ossa Fernández Enrique José
Published: June 2021

Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient’s recovery period improving its efficacy. This study intends to support the use of supercritical solvent impregnation (SSI) as an efficient technique to develop polylactic acid (PLA) functionalized with ketoprofen, for use as controlled drug release devices. For this purpose, firstly, the influence of different SSI variables on the desirable swelling of the polymer structure, while avoiding their foaming, were evaluated. Then, the resulting ketoprofen loading was evaluated under different pressure/temperature conditions. It was generally found that as pressure and temperature are higher, the drug impregnation loads also increase. The maximum impregnation loads (at about 9% KET/PLA) were obtained at 200 bar and 75 °C. In vitro drug release tests of the impregnated compound were also carried out, and it was found that drug release profiles were also dependent on the specific pressure and temperature conditions used for the impregnation of each polymer filament.
Porous Anion Exchange Membrane for Effective Acid Recovery by Diffusion Dialysis
Authors: Yang Jinbei , Dai Guangkai , Wang Jing , Pan Shuai , Lu Gang , Shi Xiaoke , Tang Danni , Chen Jinyi , Lin Xiaocheng
Published: June 2021

Diffusion dialysis (DD) employing anion exchange membranes (AEMs) presents an attractive opportunity for acid recovery from acidic wastewater. However, challenges exist to make highly acid permeable AEMs due to their low acid dialysis coefficient (Uacid). Here, a series of porous and highly acid permeable AEMs fabricated based on chloromethyl polyethersulfone (CMPES) porous membrane substrate with crosslinking and quaternization treatments is reported. Such porous AEMs show high Uacid because of the large free volume as well as the significantly reduced ion transport resistance relative to the dense AEMs. Compared with the commercial dense DF-120 AEM, our optimal porous AEM show simultaneous 466.7% higher Uacid and 75.7% higher acid/salt separation factor (Sacid/salt) when applied to acid recovery at the same condition. Further, considering the simple and efficient fabrication process as well as the low cost, our membranes show great prospects for practical acid recovery from industrial acidic wastewater.
g-C3N4 Sensitized by an Indoline Dye for Photocatalytic H2 Evolution
Authors: Chen Yihang , Liu Yanfei , Ma Zhen
Published: June 2021

Protonated g-C3N4 (pCN) formed by treating bulk g-C3N4 with an aqueous HCl solution was modified with D149 dye, i.e., 5-[[4[4-(2,2-diphenylethenyl) phenyl]-1,2,3,3a,4,8b-hexahydrocyclopent[b]indol-7-yl] methylene]-2-(3-ethyl-4-oxo-2-thioxo-5-thiazolidinylidene)-4-oxo-thiazolidin-2-ylidenerhodanine, for photocatalytic water splitting (using Pt as a co-catalyst). The D149/pCN-Pt composite showed a much higher rate (2138.2 µmol·h−1·g−1) of H2 production than pCN-Pt (657.0 µmol·h−1·g−1). Through relevant characterization, the significantly high activity of D149/pCN-Pt was linked to improved absorption of visible light, accelerated electron transfer, and more efficient separation of charge carriers. The presence of both D149 and Pt was found to be important for these factors. A mechanism was proposed.
Hydrogen Gas Quality for Gas Network Injection: State of the Art of Three Hydrogen Production Methods
Authors: Omoniyi Oluwafemi , Bacquart Thomas , Moore Niamh , Bartlett Sam , Williams Katie , Goddard Sharon , Lipscombe Bob , Murugan Arul , Jones David
Published: June 2021

The widescale distribution of hydrogen through gas networks is promoted as a viable and cost-efficient option for optimising its application in heat, industry, and transport. It is a key step towards achieving decarbonisation targets in the UK. A key consideration before the injection of hydrogen into the UK gas networks is an assessment of the difference in hydrogen contaminants presence from different production methods. This information is essential for gas regulation and for further purification requirements. This study investigates the level of ISO 14687 Grade D contaminants in hydrogen from steam methane reforming, proton exchange membrane water electrolysis, and alkaline electrolysis. Sampling and analysis of hydrogen were carried out by the National Physical Laboratory following ISO 21087 guidance. The results of analysis indicated the presence of nitrogen in hydrogen from electrolysis, and water, carbon dioxide, and particles in all samples analysed. The contaminants were at levels below or at the threshold limits set by ISO 14687 Grade D. This indicates that the investigated production methods are not a source of contaminants for the eventual utilisation of hydrogen in different applications including fuel cell electric vehicles (FCEV’s). The gas network infrastructure will require a similar analysis to determine the likelihood of contamination to hydrogen gas.
A Computational Approach for Pathway-Based Systemic Drug Influence
Authors: Kim Shinuk
Published: June 2021

Drug repositioning is a well-known method used to reduce the time, cost, and development risks involved in bringing a new drug to the market. The rapid expansion of high-throughput datasets has enabled computational research that can suggest new potential uses for existing drugs. Some computational methods allow the prediction of potential drug targets of a given disease from a systematic network. Despite numerous efforts, the path of many drugs’ efficacy in the human body remains unclear. Therefore, the present study attempted to understand drug efficacy by systematically focusing on functional gene sets. The purpose of this study was to carry out modeling to identify systemic gene networks (called drug paths) in drug-specific pathways. In our results, we found five different paths for five different drugs.
The Making of a Marian Geography of Grace for Greek Catholics in the Polish Crownlands of the 17th–18th Centuries
Authors: Stern Dieter
Published: June 2021

This article explores the ways in which the newly founded and highly contested Christian confession of the Greek Catholics or Uniates employed strategies of mass mobilization to establish and maintain their position within a contested confessional terrain. The Greek Catholic clerics, above all monks of the Basilian order fostered an active policy of acquiring, founding and promoting Marian places of grace in order to create and invigorate a sense of belonging among their flock. The article argues that folk ideological notions concerning the spatial and physical conditions for the working of miracles were seized upon by the Greek Catholic faithful to establish a mental map of grace of their own. Especially, the Basilian order took particular care to organize mass events (annual pilgrimages, coronation celebrations for miraculous images) and promote Marian devotion through miracle reports and icon songs in an attempt to define what it means to be a Greek Catholic in terms of sacred territoriality.
‘We Are Children of God’: An Ethnography of a Catholic Community in Rural China in the COVID-19 Pandemic
Authors: Xiong Wei , Li Xinan
Published: June 2021

Academic studies of the relationship between religion and pandemics have been emerging since the beginning of the COVID-19 pandemic. However, many of these studies have been conducted in Euro-American contexts, with little attention paid to non-Western cases. This article provides a local case study from China, the earliest epicenter of the pandemic. The study focused on a Catholic community in rural China, Little Rome, through the lens of lived religion, exploring the relationship between religion and the COVID-19 pandemic. Participants in our ethnographic study indicated that the Church plays an essential role in responding to the pandemic. In contrast to conventional studies of lived religion, in this ethnographic study on Catholicism in China, we contend that while the study of the lived experience of individuals is central to the lived-religion approach, more attention needs to be paid to the role of religious institutions such as the church, which mediate relations between individuals, society, and other social institutions. This article also argues that investigating different places and cultures can provide rich data for understanding the dynamic and diverse relationship between religion and the pandemic.
Economic and Non-Economic Variables Affecting Fraud in European Countries
Authors: Ahmad Bashir , Ciupac-Ulici Maria , Beju Daniela-Georgeta
Published: June 2021

Fraud is one of the most harmful phenomena, because it leads to collapse of organizations, causes economic downfall of countries, and destroys faith in a country’s capital markets. The impact of fraud is complex and has varying degrees depending on political and financial institutional structures of a country. In this paper, we investigate the combined effect of economic and non-economic variables on fraud using a sample of 41 developed, in transition, and developing European countries. The data cover the period July 2014–December 2020. Panel data techniques of pooled estimation and the dynamic panel data/generalized method of moments (DPD/GMM) is used, keeping in view the endogeneity perspective. Nevertheless, two-way impacts of fixed effect model estimation—cross-sectional and time-based (panel) effects (alternatively)—are used for analyzing the relationship among the given variables, based on Hausman specification test results. Empirical results of panel data extended REM and FEM approaches with country-specific cross-sectional effects showing that political stability, economic freedom, poverty, and GDP significantly affect fraud proliferation. Political stability is appraised to be the most scoring determinant of fraud incidence in a country.
Soft-Tentacle Gripper for Pipe Crawling to Inspect Industrial Facilities Using UAVs
Authors: Garcia Rubiales F. Javier , Ramon Soria Pablo , Arrue Begoña C. , Ollero Anibal
Published: June 2021

This paper presents a crawling mechanism using a soft-tentacle gripper integrated into an unmanned aerial vehicle for pipe inspection in industrial environments. The objective was to allow the aerial robot to perch and crawl along the pipe, minimizing the energy consumption, and allowing to perform contact inspection. This paper introduces the design of the soft limbs of the gripper and also the internal mechanism that allows movement along pipes. Several tests have been carried out to ensure the grasping capability on the pipe and the performance and reliability of the developed system. This paper shows the complete development of the system using additive manufacturing techniques and includes the results of experiments performed in realistic environments.
Low-Cost Reliable Corrosion Sensors Using ZnO-PVDF Nanocomposite Textiles
Authors: Chowdhury Tonoy , D’Souza Nandika , Dahotre Narendra
Published: June 2021

Submerged steel pipes are susceptible to corrosion due to long exposure under harsh corrosive conditions. Here, we investigated the reliability and effectiveness of nonwoven zinc(II) oxide-polyvinylidene fluoride (ZnO-PVDF) nanocomposite fiber textiles as an embedded corrosion sensor. An accelerated thermal cyclic method paired to electrochemical impedance spectroscopy (EIS) was used for this purpose. Sensor accuracy and reliability were determined using the textile and instrument as reference electrodes. The results showed that the coating and the sensor improved the corrosion resistance when ZnO was added to the sensor textile and introduced into the coating. As the coating’s glass transition was approached, the corrosion performance of the coating degraded and the sensor accuracy decreased. The results suggested that the flexible sensor is reliable at both monitoring the corrosion and acting as a corrosion barrier.
Open-Circuit Fault Detection and Classification of Modular Multilevel Converters in High Voltage Direct Current Systems (MMC-HVDC) with Long Short-Term Memory (LSTM) Method
Authors: Wang Qinghua , Yu Yuexiao , Ahmed Hosameldin O. A. , Darwish Mohamed , Nandi Asoke K.
Published: June 2021

Fault detection and classification are two of the challenging tasks in Modular Multilevel Converters in High Voltage Direct Current (MMC-HVDC) systems. To directly classify the raw sensor data without certain feature extraction and classifier design, a long short-term memory (LSTM) neural network is proposed and used for seven states of the MMC-HVDC transmission power system simulated by Power Systems Computer Aided Design/Electromagnetic Transients including DC (PSCAD/EMTDC). It is observed that the LSTM method can detect faults with 100% accuracy and classify different faults as well as provide promising fault classification performance. Compared with a bidirectional LSTM (BiLSTM), the LSTM can get similar classification accuracy, requiring less training time and testing time. Compared with Convolutional Neural Networks (CNN) and AutoEncoder-based deep neural networks (AE-based DNN), the LSTM method can get better classification accuracy around the middle of the testing data proportion, but it needs more training time.
Pattern Recognition in Music on the Example of Reconstruction of Chest Organ from Kamień Pomorski
Authors: Wrzeciono Piotr
Published: June 2021

The chest organ, which gained popularity at the beginning of the 17th century, is a small pipe organ the size of a large box. Several years ago, while compiling an inventory, a previously unidentified chest organ was discovered at St. John the Baptist’s Co-Cathedral in Kamień Pomorski. Regrettably, the instrument did not possess any of its original pipes. What remained, however, was an image of the front pipes preserved on the chest door. The main issue involved in the reconstruction of a historic instrument is the restoration of its original tuning (temperament). Additionally, it is important to establish the frequency of A4, as this sound serves as a standard pitch reference in instrument tuning. The study presents a new method that aims to address the above-mentioned problems. To this end, techniques to search for the most probable temperament and establish the correct A4 frequency were developed. The solution is based on the modeling of sound generation in flue pipes, as well as statistical analysis to help match a model to the parameters preserved in the chest organ drawing. Additionally, differentalues of the A4 sound values were defined for temperatures ranging from 10 ∘C to 20 ∘C. The tuning system proposed in 1523 by Pietro Aaron proved to be the most probable temperament. In the process of testing the developed flue pipe model, the maximum tuning temperature was established as 15.8 ∘C.
Police Stop and Frisk and the Impact of Race: A Focal Concerns Theory Approach
Authors: Vito Anthony , Higgins George , Vito Gennaro
Published: June 2021

The findings of this study outline the racial differences in stop and frisk decisions by Illinois officers in consent searches and those based upon reasonable suspicion within the context of the elements of focal concerns theory. The analysis for this study was performed using propensity score matching (PSM) and allowed the researchers to create a quasi-experimental design to examine the race of the citizen and police decision making. According to our analysis of official Illinois law enforcement data, Black citizens, particularly males, were less likely to give their consent to a stop and frisk search. Black male citizens were also more likely to be stopped and searched due to an assessment of reasonable suspicion by the officer. Elements of focal concerns theory were also factors in pedestrian stops under conditions of consent and reasonable suspicion. Citizens judged as blameworthy were more likely to be stopped and frisked under conditions of consent and reasonable suspicion. The effect of a verbal threat and the officer’s prior knowledge about the citizen had even more significant impacts.
Sustainability of Public Finance through the Lens of Transfer Prices and Their Associated Risks: An Empirical Research
Authors: Luca Mihaela Paraschiva , Tache Ileana
Published: June 2021

At a time when the world economy is being affected by the COVID-19 pandemic, we are more aware than ever of the importance of the sustainability of public finances. This paper outlines its importance by discussing transfer prices and their fiscal associated risks. In the current economic context, marked by the crisis and by an increasing pressure from the control authorities on companies, no matter how important the theoretical research, it cannot capture very well the pulse of practical activity. Under these conditions, empirical studies are becoming increasingly important, requiring an approach to practical economic reality. In order to analyze the way in which companies that carry out transactions with affiliated parties approach the transfer prices and the risks related to them, we conducted an empirical, quantitative research using the CAWI method (Computer Assisted Web Interviewing) and the questionnaire. The research results demonstrate an awareness by the responding companies of the importance of transfer pricing and their risks, the transactions most prone to control in this area being those of financing within the group, followed equally by management services, consulting, assistance and transactions with goods. In the face of legislation that leaves room for interpretation and a high number of controls on transfer pricing, a small number of companies participating in the research have used the Advance Price Agreement as a tool to reduce the tax risk associated with transfer pricing. Companies also face uncertainty about how ongoing global tax reforms will affect them in the coming period.