bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies
Authors: Elder Greg J. , Mactier Karen , Colloby Sean J. , Watson Rosie , Blamire Andrew M. , O'Brien John T. , Taylor John‐Paul
Published: April 2017

Objective

The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures.

Methods

Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini‐Mental State Examination (CAMCOG and MMSE) assessments. Hippocampal volume, and parahippocampal, entorhinal and temporal pole cortical thickness, was compared between groups. Regression models were used to investigate whether hippocampal volume and cortical thickness associated with global cognition and cognitive subdomains.

Results

Dementia with Lewy bodies, AD and control participants showed significantly different hippocampal, parahippocampal and entorhinal cortical thinning, where atrophy was greatest in AD and intermediate in DLB. Temporal pole thickness was reduced in DLB and AD compared with control participants. In DLB, but not AD, hippocampal volume associated with total CAMCOG, CAMCOG memory and MMSE scores. In DLB, parahippocampal, entorhinal and temporal pole thickness associated with total CAMCOG and CAMCOG memory scores, parahippocampal thickness associated with MMSE scores, and entorhinal thickness associated with CAMCOG executive function scores.

Conclusions

In this large sample, these results are in agreement with other studies indicating that hippocampal atrophy is less severe in DLB than AD. Hippocampal atrophy and medial temporal lobe cortical thickness were associated with the severity of cognitive symptoms, suggesting that atrophy in these structures, as a potential proxy of AD pathology, may partly mediate specific DLB cognitive symptoms. © 2017 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.
Climatology and trends of the Adriatic Sea wind waves: analysis of a 37‐year long instrumental data set
Authors: Pomaro Angela , Cavaleri Luigi , Lionello Piero
Published: April 2017

This study concerns the analysis of a 37‐year long directional wave time series recorded since 1979 at the CNR‐ISMAR oceanographic research tower, located in the Northern Adriatic Sea. The length of the time series allows to describe the wave climate in the North Adriatic and to identify trends and links with large‐scale climate patterns. The northern part of the Adriatic Sea is characterized by two main wind and correspondingly wave regimes, strongly forced by the regional orography: the long‐fetch south‐easterly ‘sirocco’ and the short‐fetch strong north‐easterly ‘bora’ wind generated waves, blowing along the major and minor axis of the basin, respectively. Bora is the most frequent regime, but high waves are mostly associated to sirocco. A clear decrease of the significant wave height 99th percentile is evident, paralleled by a smaller, but distributed along the annual cycle, increase of the 50th and 75th ones. The estimated trend of the frequency of events above a certain threshold confirms an increase of the average storm frequency, with a shift from both the lower and the higher to the central part of the distribution, paralleled by a decrease of the maximum Hs values. In particular, a distributed decrease of the bora significant wave height is recognized. For sirocco the tendency is less pronounced, but with an evident increase of the frequency of the mean values. The high sensitivity of this particular area to even small variations of large‐scale climate allows to explore possible links of the local wave, hence wind, activity with large‐scale Northern Hemisphere circulation patterns or weather regimes. Our main interest is on the storm tracks and jet stream location/intensity over vast areas, which led us to choose four reference patterns: the North Atlantic Oscillation and the East Atlantic (EA), EA/Western Russia and Scandinavian patterns.
Natural terpene derivatives as new structural task‐specific ionic liquids to enhance the enantiorecognition of acidic enantiomers on teicoplanin‐based stationary phase by high‐performance liquid chromatography
Authors: Flieger Jolanta , Feder‐Kubis Joanna , Tatarczak‐Michalewska Małgorzata , Płazińska Anita , Madejska Anna , Swatko‐Ossor Marta
Published: April 2017

We present the specific cooperative effect of a semisynthetic glycopeptide antibiotic teicoplanin and chiral ionic liquids containing the (1R,2S,5R)‐(–)‐menthol moiety on the chiral recognition of enantiomers of mandelic acid, vanilmandelic acid, and phenyllactic acid. Experiments were performed chromatographically on an Astec Chirobiotic T chiral stationary phase applying the mobile phase with the addition of the chiral ionic liquids. The stereoselective binding of enantiomers to teicoplanin in presence of new chiral ionic liquids were evaluated applying thermodynamic measurements and the docking simulations. Both the experimental and theoretical methods revealed that the chiral recognition of enantiomers in the presence of new chiral ionic liquids was enthalpy driven. The changes of the teicoplanin conformation occurring upon binding of the chiral ionic liquids are responsible for the differences in the standard changes in Gibbs energy (ΔG0) values obtained for complexes formed by the R and S enantiomers and teicoplanin. Docking simulations revealed the steric adjustment between the chiral ionic liquids cyclohexane ring (chair conformation) and the β‐d‐glucosamine ring of teicoplanin and additionally hydrophobic interactions between the decanoic aliphatic chain of teicoplanin and the alkyl group of the tested salts. The obtained terpene derivatives can be considered as “structural task‐specific ionic liquids” responsible for enhancing the chiral resolution in synergistic systems with two chiral selectors.
A multiplex culture system for the long‐term growth of fission yeast cells
Authors: Callens Céline , Coelho Nelson C. , Miller Aaron W. , Sananes Maria Rosa Domingo , Dunham Maitreya J. , Denoual Matthieu , Coudreuse Damien
Published: April 2017

Maintenance of long‐term cultures of yeast cells is central to a broad range of investigations, from metabolic studies to laboratory evolution assays. However, repeated dilutions of batch cultures lead to variations in medium composition, with implications for cell physiology. In Saccharomyces cerevisiae, powerful miniaturized chemostat setups, or ministat arrays, have been shown to allow for constant dilution of multiple independent cultures. Here we set out to adapt these arrays for continuous culture of a morphologically and physiologically distinct yeast, the fission yeast Schizosaccharomyces pombe, with the goal of maintaining constant population density over time. First, we demonstrated that the original ministats are incompatible with growing fission yeast for more than a few generations, prompting us to modify different aspects of the system design. Next, we identified critical parameters for sustaining unbiased vegetative growth in these conditions. This requires deletion of the gsf2 flocculin‐encoding gene, along with addition of galactose to the medium and lowering of the culture temperature. Importantly, we improved the flexibility of the ministats by developing a piezo‐pump module for the independent regulation of the dilution rate of each culture. This made it possible to easily grow strains that have different generation times in the same assay. Our system therefore allows for maintaining multiple fission yeast cultures in exponential growth, adapting the dilution of each culture over time to keep constant population density for hundreds of generations. These multiplex culture systems open the door to a new range of long‐term experiments using this model organism. © 2017 The Authors. Yeast published by John Wiley & Sons, Ltd.
THE TWILIGHT OF OTTOMAN SUFISM: ANTIQUITY, IMMORALITY, AND NATION IN YAKUP KADRI KARAOSMANOĞLU'SNUR BABA
Authors: Wilson M. Brett
Published: April 2017

This article examines modernist-nationalist thought on Sufi lodges during the late Ottoman Empire and early Turkish Republic via the controversial novelNur Baba(1922) by Yakup Kadri Karaosmanoğlu. Widely translated and the basis of the first-ever Turkish motion picture,Nur Babadepicts a debauched Sufi lodge in turn-of-the-century Istanbul where drug use, alcoholism, and illicit amorous liaisons run amok. The novel played an important role in shaping public perceptions of Sufi lodges in the twilight years of the Ottoman Empire. This piece explores the novel's place among early 20th-century critiques of Sufism, its approach to national history, its historical setting (during the reign of Sultan Abdülhamid II), and its close relationship to the intellectual concerns of the Second Constitutional Period (1908–18). It argues for a revised understanding of the novel's historical setting and contends that the novel employs a combination of moralistic critique and romantic nostalgia that is central to modernist-nationalist treatments of Sufism that instrumentalize Sufi culture for nation-building purposes.
The Middle East without Space?
Authors: Hammond Timur
Published: April 2017

One of the first ways that many scholars of the Middle East encounter the region is precisely through the lens of “region” itself. Our ability to know the Middle East as a region today, we learn, is a complicated inheritance of imperialism, Orientalism, and Cold War area studies scholarship. To study the Middle East as the “Middle East,” in other words, is to be necessarily positioned within a contested and unequal field of knowledge, one whose contours are both historically and geographically specific. Much of the best research and teaching within Middle East studies continues to demonstrate that knowingaboutthe region—and the world more broadly—is closely entwined with the politicsofthe region. The interdisciplinary spatial turn within Middle East studies has been and continues to be so fertile precisely because of that reflexivity.
Urban Transformations in the Middle East and North Africa from a Geographical Perspective
Authors: Atia Mona
Published: April 2017

Though a multidisciplinary field, Middle East studies has historically had little engagement with the theoretical and methodological contributions of the discipline of geography. In the wake of the Arab Spring, there was a turning point, as scholars of the region noted the importance of public space to the uprisings, thus sparking engaging debates about urban spatial politics. In fact, Middle East studies is not alone in its newfound affinity to geography; a shift to what many have called “the spatial turn” across the social sciences and humanities has put geography in the limelight. Geography is in fact the original “area” studies—geographers of the early 20th century saw the main rationale of their discipline as identifying and describing regions, and the region was the core geographical concept. The post–World War II area studies boom occurred much at the expense of the discipline; after Harvard University closed its geography program in 1948, the University of Pennsylvania, Yale University, Columbia University, and other Ivy League schools soon followed and Title VI essentially led to the closing of numerous other geography programs around the country—including Stanford University, the University of Michigan, Northwestern University, and the University of Chicago. A growing sentiment within the ivory tower found the discipline too ambiguous and asserted that a university did not need geography to be a great institution.
Influence of opacification in the frontal recess on frontal sinusitis
Authors: Hashimoto K , Tsuzuki K , Okazaki K , Sakagami M
Published: April 2017

Objectives:

This study aimed to radiologically evaluate the influence of inflammatory changes in frontal recess cells on frontal sinusitis.

Methods:

A total of 93 patients (186 sides) who underwent primary sinonasal surgery at Hyogo College of Medicine were enrolled in 2015 and 2016. Opacification of agger nasi, fronto-ethmoidal, ethmoid bulla, suprabullar and frontal bulla cells was determined by pre-operative computed tomography and its influence on frontal sinusitis was investigated.

Results:

In all, 42 per cent of 186 sides were affected by frontal sinusitis. Agger nasi, ethmoid bulla, fronto-ethmoidal, suprabullar and frontal bulla cells were identified in 99 per cent, 100 per cent, 38 per cent, 69 per cent, and 16 per cent of sides, respectively. The presence of frontal recess cells and frontal ostium size did not significantly influence frontal sinusitis development. However, opacification of agger nasi, type 1 fronto-ethmoidal and suprabullar cells significantly influenced frontal sinusitis development.

Conclusion:

Frontal sinusitis is caused by inflammatory changes in frontal recess cells.
Financial knowledge and key retirement outcomes: an overview of the issue
Authors: MITCHELL OLIVIA S.
Published: April 2017

This special issue on financial knowledge and retirement security builds on prior studies in this journal on the economic causes and consequences of financial literacy for retirement security.
Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation
Authors: Gigante Crystal M. , Dibattista Michele , Dong Frederick N. , Zheng Xiaobin , Yue Sibiao , Young Stephen G. , Reisert Johannes , Zheng Yixian , Zhao Haiqing
Published: April 2017

B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direct link between B-type lamins and developmental gene expression in an in vivo system is currently lacking. Here, we identify lamin B1 as a key regulator of gene expression required for the formation of functional olfactory sensory neurons. By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation. This deficit can be explained by decreased expression of genes involved in mature neuron function, along with increased expression of genes atypical of the olfactory lineage. These results support that the broadly expressed lamin B1 regulates expression of a subset of genes involved in the differentiation of a specific cell type.
Correction: Corrigendum: Coherent creation and destruction of orbital wavepackets in Si:P with electrical and optical read-out
Authors: Litvinenko K. L. , Bowyer E. T. , Greenland P. T. , Stavrias N. , Li Juerong , Gwilliam R. , Villis B. J. , Matmon G. , Pang M. L. Y. , Redlich B. , van der Meer A. F. G. , Pidgeon C. R. , Aeppli G. , Murdin B. N.
Published: April 2017

Nature Communications 6: Article number: 6549 (2015); Published: 20 March 2015; Updated: 20 April 2017 This Article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly.
Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Authors: Hillion Melanie , Bernhardt Jörg , Busche Tobias , Rossius Martina , Maaß Sandra , Becher Dörte , Rawat Mamta , Wirtz Markus , Hell Rüdiger , Rückert Christian , Kalinowski Jörn , Antelmann Haike
Published: April 2017

Mycothiol (MSH) is the major low molecular weight (LMW) thiol in Actinomycetes. Here, we used shotgun proteomics, OxICAT and RNA-seq transcriptomics to analyse protein S-mycothiolation, reversible thiol-oxidations and their impact on gene expression in Mycobacterium smegmatis under hypochlorite stress. In total, 58 S-mycothiolated proteins were identified under NaOCl stress that are involved in energy metabolism, fatty acid and mycolic acid biosynthesis, protein translation, redox regulation and detoxification. Protein S-mycothiolation was accompanied by MSH depletion in the thiol-metabolome. Quantification of the redox state of 1098 Cys residues using OxICAT revealed that 381 Cys residues (33.6%) showed >10% increased oxidations under NaOCl stress, which overlapped with 40 S-mycothiolated Cys-peptides. The absence of MSH resulted in a higher basal oxidation level of 338 Cys residues (41.1%). The RseA and RshA anti-sigma factors and the Zur and NrdR repressors were identified as NaOCl-sensitive proteins and their oxidation resulted in an up-regulation of the SigH, SigE, Zur and NrdR regulons in the RNA-seq transcriptome. In conclusion, we show here that NaOCl stress causes widespread thiol-oxidation including protein S-mycothiolation resulting in induction of antioxidant defense mechanisms in M. smegmatis. Our results further reveal that MSH is important to maintain the reduced state of protein thiols.
Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
Authors: Koo Youngmi , Tiasha Tarannum , Shanov Vesselin N. , Yun Yeoheung
Published: April 2017

A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH)2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.
Large-scale SNP screenings identify markers linked with GCRV resistant traits through transcriptomes of individuals and cell lines in Ctenopharyngodon idella
Authors: Liao Zhiwei , Wan Quanyuan , Shang Xueying , Su Jianguo
Published: April 2017

Grass carp (Ctenopharyngodon idella) is an important economic species in freshwater aquaculture and its industry has been confined due to variety degeneration and frequent diseases. Marker-assisted selection is a feasible method for selective breeding of new varieties. Transcriptome data have greatly facilitated high-throughput single nucleotide polymorphism (SNP) marker discovery and phenotype association study. In this study, we gained a total of 25,981 and 5,775 high quality SNPs in two transcriptomes from individuals and cell lines, respectively. Comparative transcriptome analysis identified 413 and 832 grass carp reovirus (GCRV)-resistant-association SNPs as well as 1,381 and 1,606 GCRV-susceptible-association SNPs in individuals and cell lines, respectively. Integrated analysis indicated 22 genes with single SNP share common resistant/susceptible traits in two transcriptomes. Furthermore, we infected grass carp with GCRV, genotyping and association analyses were performed, and 9 in 22 SNPs were confirmed by PCR-RFLP. Meanwhile, mRNA expression profiles of 6 genes containing confirmed SNPs were examined by qRT-PCR. The results demonstrated that mRNA expressions were significant differences in resistant/susceptible individuals and cell lines. The present study develops an important strategy for high throughput screening of phenotype association genetic markers and the results will serve in grass carp breeding for GCRV resistance.
Resolution-enhanced Fourier ptychographic microscopy based on high-numerical-aperture illuminations
Authors: Sun Jiasong , Zuo Chao , Zhang Liang , Chen Qian
Published: April 2017

High-resolution and wide field-of-view (FOV) microscopic imaging plays a central role in diverse applications such as high-throughput screening and digital pathology. However, conventional microscopes face inherent trade-offs between the spatial resolution and FOV, which are fundamental limited by the space-bandwidth product (SBP) of the optical system. The resolution-FOV tradeoff can be effectively decoupled in Fourier ptychography microscopy (FPM), however, to date, the effective imaging NA achievable with a typical FPM system is still limited to the range of 0.4–0.7. Herein, we report, for the first time, a high-NA illumination based resolution-enhanced FPM (REFPM) platform, in which a LED-array-based digital oil-immersion condenser is used to create high-angle programmable plane-wave illuminations, endowing a 10×, 0.4 NA objective lens with final effective imaging performance of 1.6 NA. With REFPM, we present the highest-resolution results with a unprecedented half-pitch resolution of 154 nm at a wavelength of 435 nm across a wide FOV of 2.34 mm2, corresponding to an SBP of 98.5 megapixels (~50 times higher than that of the conventional incoherent microscope with the same resolution). Our work provides an important step of FPM towards high-resolution large-NA imaging applications, generating comparable resolution performance but significantly broadening the FOV of conventional oil-immersion microscopes.
A common neonicotinoid pesticide, thiamethoxam, impairs honey bee flight ability
Authors: Tosi Simone , Burgio Giovanni , Nieh James C.
Published: April 2017

Pesticides can pose environmental risks, and a common neonicotinoid pesticide, thiamethoxam, decreases homing success in honey bees. Neonicotinoids can alter bee navigation, but we present the first evidence that neonicotinoid exposure alone can impair the physical ability of bees to fly. We tested the effects of acute or chronic exposure to thiamethoxam on the flight ability of foragers in flight mills. Within 1 h of consuming a single sublethal dose (1.34 ng/bee), foragers showed excitation and significantly increased flight duration (+78%) and distance (+72%). Chronic exposure significantly decreased flight duration (−54%), distance (−56%), and average velocity (−7%) after either one or two days of continuous exposure that resulted in bees ingesting field-relevant thiamethoxam doses of 1.96–2.90 ng/bee/day. These results provide the first demonstration that acute or chronic exposure to a neonicotinoid alone can significantly alter bee flight. Such exposure may impair foraging and homing, which are vital to normal colony function and ecosystem services.
Inkjet Printing of High Performance Transistors with Micron Order Chemically Set Gaps
Authors: Grubb Peter Mack , Subbaraman Harish , Park Saungeun , Akinwande Deji , Chen Ray T.
Published: April 2017

This paper reports a 100% inkjet printed transistor with a short channel of approximately 1 µm with an operating speed up to 18.21 GHz. Printed electronics are a burgeoning area in electronics development, but are often stymied by the large minimum feature size. To combat this, techniques were developed to allow for the printings of much shorter transistor channels. The small gap size is achieved through the use of silver inks with different chemical properties to prevent mixing. The combination of the short channel and semiconducting carbon nanotubes (CNT) allows for an exceptional experimentally measured on/off ratio of 106. This all inkjet printed transistor allows for the fabrication of devices using roll-to-roll methodologies with no additional overhead compared to current state of the art production methods.
Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools
Authors: Schleusener Viola , Köser Claudio U. , Beckert Patrick , Niemann Stefan , Feuerriegel Silke
Published: April 2017

Whole-genome sequencing (WGS) has the potential to accelerate drug-susceptibility testing (DST) to design appropriate regimens for drug-resistant tuberculosis (TB). Several recently developed automated software tools promise to standardize the analysis and interpretation of WGS data. We assessed five tools (CASTB, KvarQ, Mykrobe Predictor TB, PhyResSE, and TBProfiler) with regards to DST and phylogenetic lineage classification, which we compared with phenotypic DST, Sanger sequencing, and traditional typing results for a collection of 91 strains. The lineage classifications by the tools generally only differed in the resolution of the results. However, some strains could not be classified at all and one strain was misclassified. The sensitivities and specificities for isoniazid and rifampicin resistance of the tools were high, whereas the results for ethambutol, pyrazinamide, and streptomycin resistance were more variable. False-susceptible DST results were mainly due to missing mutations in the resistance catalogues that the respective tools employed for data interpretation. Notably, we also found cases of false-resistance because of the misclassification of polymorphisms as resistance mutations. In conclusion, the performance of current WGS analysis tools for DST is highly variable. Sustainable business models and a shared, high-quality catalogue of resistance mutations are needed to ensure the clinical utility of these tools.
2D-DIGE as a strategy to identify serum biomarkers in Mexican patients with Type-2 diabetes with different body mass index
Authors: Gómez-Cardona Erik E. , Hernández-Domínguez Eric E. , Velarde-Salcedo Aída J. , Pacheco Alberto-Barrera- , Diaz-Gois Agustín , De León-Rodríguez Antonio , Barba de la Rosa Ana P.
Published: April 2017

Obesity and type 2 diabetes(T2D) are the most prevalent and serious metabolic diseases affecting people worldwide. However racial and ethnic disparities seems to be a risk factor for their development. Mexico has been named as one of the largest populations with the highest prevalence of diabetes and obesity. The aim of this study was to identify novel T2D-associated proteins in Mexican patients. Blood samples were collected from 62 Mexican patients with T2D and they were grouped according to their body mass index(BMI). A panel of 10 diabetes and obesity serum markers was determined using MAGPIX. A comparative proteomics study was performed using two-dimensional difference in-gel electrophoresis(2D-DIGE) followed by mass spectrometry(LC-MS/MS). We detected 113 spots differentially accumulated, in which 64 unique proteins were identified, proteins that were involved in metabolism pathways, molecular transport, and cellular signalling. Four proteins(14-3-3, ApoH, ZAG, and OTO3) showing diabetes-related variation and also changes in relation to obesity were selected for further validation by western blotting. Our results reveal new diabetes related proteins present in the Mexican population. These could provide additional insight into the understanding of diabetes development in Mexican population and may also be useful candidate biomarkers.
Oncogenic activity of SOX1 in glioblastoma
Authors: Garcia Idoia , Aldaregia Juncal , Marjanovic Vicentic Jelena , Aldaz Paula , Moreno-Cugnon Leire , Torres-Bayona Sergio , Carrasco-Garcia Estefania , Garros-Regulez Laura , Egaña Larraitz , Rubio Angel , Pollard Steven , Stevanovic Milena , Sampron Nicolas , Matheu Ander
Published: April 2017

Glioblastoma remains the most common and deadliest type of brain tumor and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contributes to tumor initiation and treatment resistance. Developmental programs participating in tissue development and homeostasis re-emerge in GSCs, supporting the development and progression of glioblastoma. SOX1 plays an important role in neural development and neural progenitor pool maintenance. Its impact on glioblastoma remains largely unknown. In this study, we have found that high levels of SOX1 observed in a subset of patients correlate with lower overall survival. At the cellular level, SOX1 expression is elevated in patient-derived GSCs and it is also higher in oncosphere culture compared to differentiation conditions in conventional glioblastoma cell lines. Moreover, genetic inhibition of SOX1 in patient-derived GSCs and conventional cell lines decreases self-renewal and proliferative capacity in vitro and tumor initiation and growth in vivo. Contrarily, SOX1 over-expression moderately promotes self-renewal and proliferation in GSCs. These functions seem to be independent of its activity as Wnt/β-catenin signaling regulator. In summary, these results identify a functional role for SOX1 in regulating glioma cell heterogeneity and plasticity, and suggest SOX1 as a potential target in the GSC population in glioblastoma.
Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes
Authors: Spiegler V. , Liebau E. , Hensel A.
Published: April 2017

A review of knowledge on plant extracts with known polyphenolic composition and of defined polyphenols against intestinal nematodes, focussing on polyphenols mainly from condensed and hydrolysable tannins, flavonoids and phenylpropanoids and their diverse biological activity against different helminths including the underlying mechanisms.
Characterization of complexes made of polylysine–polyleucine–polylysine and pDNA
Authors: Chen Baizhu , Yu Lei , Li Zhibo
Published: April 2017

Polylysine shows unique physical and biological abilities in its application.
Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter
Authors: Hossain Md Arafat , Canning John , Yu Zhikang , Ast Sandra , Rutledge Peter J. , Wong Joseph K.-H. , Jamalipour Abbas , Crossley Maxwell J.
Published: April 2017

A smartphone fluorimeter is demonstrated for steady-state and time-resolved fluorescence intensity measurements at tunable temperatures.
Orienting spins in dually doped monolayer MoS2: from one-sided to double-sided doping
Authors: Vähäkangas J. , Lantto P. , Vaara J. , Huttula M. , Cao W.
Published: April 2017

Single- and double-sided doped monolayer MoS2show electron spin alignments with their origins beyond explanations of the existing models.
Unique site-selectivity control in asymmetric Michael addition of azlactone to alkenyl dienyl ketones enabled by P-spiro chiral iminophosphorane catalysis
Authors: Yoshioka Ken , Yamada Kohei , Uraguchi Daisuke , Ooi Takashi
Published: April 2017

Simultaneous recognition of distance and direction of conjugation from carbonyl in alkenyl dienyl ketones enables a highly site-selective asymmetric 1,6-addition.
Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes
Authors: Javanainen Matti , Melcrová Adéla , Magarkar Aniket , Jurkiewicz Piotr , Hof Martin , Jungwirth Pavel , Martinez-Seara Hector
Published: April 2017

Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion.
A Co-based single-molecule magnet confined in a barium phosphate apatite matrix with a high energy barrier for magnetization relaxation
Authors: Kazin Pavel E. , Zykin Mikhail A. , Trusov Lev A. , Eliseev Artem A. , Magdysyuk Oxana V. , Dinnebier Robert E. , Kremer Reinhard K. , Felser Claudia , Jansen Martin
Published: April 2017

A Co-ion introduced into the trigonal channel of an apatite-type lattice forms a magnetically anisotropic two-coordinated Co-complex with a record-high spin-reversal energy barrier.
Construction of two heteropore covalent organic frameworks with Kagome lattices
Authors: Tian Yuan , Xu Shun-Qi , Liang Rong-Ran , Qian Cheng , Jiang Guo-Fang , Zhao Xin
Published: April 2017

Two novel covalent organic frameworks (COFs) bearing Kagome lattices have been fabricated through the condensations of a D2h symmetrical tetraaldehyde and C2 symmetrical aromatic diamines of various lengths.
Influence of cosolvents, self-crowding, temperature and pressure on the sub-nanosecond dynamics and folding stability of lysozyme
Authors: Al-Ayoubi S. R. , Schummel P. H. , Golub M. , Peters J. , Winter R.
Published: April 2017

Self-crowding and osmolytes are able to affect the fast dynamics of proteins more efficiently than hydrostatic pressure.
Dual spectra band emissive Eu2+/Mn2+co-activated alkaline earth phosphates for indoor plant growth novel phosphor converted-LEDs
Authors: Yun Young Jun , Kim Jin Kyu , Ju Ji Young , Choi Seul Ki , Park Woon Ik , Suh Jae Yong , Jung Ha-kyun , Kim Yongseon , Choi Sungho
Published: April 2017

Tunable emission band illuminating single composition phosphates-converted LEDs for eco-friendly indoor plant growth.
Giant magnetic anisotropy of rare-earth adatoms and dimers adsorbed by graphene oxide
Authors: Zhang Kai-Cheng , Li Yong-Feng , Liu Yong , Zhu Yan , Shi Li-Bin
Published: April 2017

The rare-earth dimers adsorbed onto graphene oxide possess huge magnetic anisotropy which can be effectively tuned by electric field.
Ionic behavior of organic–inorganic metal halide perovskite based metal-oxide-semiconductor capacitors
Authors: Wang Yucheng , Zhang Yuming , Pang Tiqiang , Xu Jie , Hu Ziyang , Zhu Yuejin , Tang Xiaoyan , Luan Suzhen , Jia Renxu
Published: April 2017

Organic–inorganic metal halide perovskites are promising semiconductors for optoelectronic applications.
On the decay of the triplet state of thionucleobases
Authors: Bai Shuming , Barbatti Mario
Published: April 2017

The double-well triplet state of thionucleobases allows for a two-step mechanistic control of their triplet decay lifetime.
Breakdown of the Stokes–Einstein water transport through narrow hydrophobic nanotubes
Authors: Köhler Mateus Henrique , Bordin José Rafael , da Silva Leandro B. , Barbosa Marcia C.
Published: April 2017

As water density is increased inside narrow hydrophobic nanotubes, the viscosity shows a huge increase associated with a small increase in the diffusion, which violates the Stokes–Einstein relation.
Emerging tellurium nanostructures: controllable synthesis and their applications
Authors: He Zhen , Yang Yuan , Liu Jian-Wei , Yu Shu-Hong
Published: April 2017

This review summarizes the recent advances in the design and controlled synthesis of Te nanostructures, their novel properties and potential applications.
Supplementation with n-3, n-6, n-9 fatty acids in an insulin-resistance animal model: does it improve VLDL quality?
Authors: Lucero D. , Olano C. , Bursztyn M. , Morales C. , Stranges A. , Friedman S. , Macri E. V. , Schreier L. , Zago V.
Published: April 2017

Could supplementation with n-3, n-6 and n-9 fatty acids prevent atherogenic alterations of VLDL produced in insulin-resistance?
Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives
Authors: Díaz José Luis , Corbera Jordi , Cuberes Rosa , Contijoch Montserrat , Enrech Raquel , Yeste Sandra , Montero Ana , Dordal Albert , Monroy Xavier , Almansa Carmen
Published: April 2017

The 4-acylaminopyrazolo[3,4-d]pyrimidine 9a was identified as a highly selective σ1R antagonist, showing as well substantial antinociceptive properties.
All-organic luminescent nanodots from corannulene and cyclodextrin nano-assembly: continuous-flow synthesis, non-linear optical properties, and bio-imaging applications
Authors: Sreejith Sivaramapanicker , Menon Nishanth Venugopal , Wang Yue , Joshi Hrishikesh , Liu Shiying , Chong Kok Chan , Kang Yuejun , Sun Handong , Stuparu Mihaiela C.
Published: April 2017

Supramolecular interactions between a curved polycyclic hydrocarbon and a cyclic oligosaccharide is shown to furnish functional nanostructures under flow conditions.
Delving into Zika virus structural dynamics – a closer look at NS3 helicase loop flexibility and its role in drug discovery
Authors: Ramharack Pritika , Oguntade Sofiat , Soliman Mahmoud E. S.
Published: April 2017

This study demonstrates the structural alterations in the P-loop of ZIKV helicase subsequent to binding of potent inhibitor, NITD008.
Changes in molecular film metallicity with minor modifications of the constitutive quinonoid zwitterions
Authors: Routaboul Lucie , Tanabe Iori , Santana Juan Colon , Yuan Minghui , Ghisolfi Alessio , Garcia William Serrano , Dowben Peter A. , Doudin Bernard , Braunstein Pierre
Published: April 2017

The electronic properties of molecular films formed by quinonoid zwitterions deposited on gold are highly dependent on the nature of the N-substituent.
pH responsive vesicles with tunable size formed by single-tailed surfactants with a dendritic headgroup
Authors: Xie Hongtao , Lu Wensheng , Wang Jide , Wang Wei
Published: April 2017

Vesicles of variable sizes are obtained by changing pH with single-tailed dendritic surfactants.
Acute and chronic effects of roxarsone on biological nitrogen and phosphorus removal and its mechanism
Authors: Huang Weijiang , Sun Shengjin , Gao Zhao , Chen Yu , Wu Lin
Published: April 2017

Effect of roxarsone on the removal of nutrients from wastewater.
An N-nitrosation reactivity-based two-photon fluorescent probe for the specific in situ detection of nitric oxide
Authors: Mao Zhiqiang , Jiang Hong , Li Zhen , Zhong Cheng , Zhang Wei , Liu Zhihong
Published: April 2017

An N-nitrosation reactivity-based two-photon fluorescent probe for the specific detection of NO was rationally designed, prepared, and applied in the in situ detection of nitric oxide in ischemia reperfusion injury mouse model under two-photon microscopy for the first time.
Periodontal tissue engineering: current strategies and the role of platelet rich hemoderivatives
Authors: Babo Pedro S. , Reis Rui L. , Gomes Manuela E.
Published: April 2017

Periodontal tissue engineering procures to regenerate the periodontal tissue assuring the right combination of scaffolds, biochemical cues and cells. The platelet rich hemoderivatives might provide the adequate growth factors and structural proteins for the predictable regeneration of periodontium.
A multicoloured Au NCs based cross-reactive sensor array for discrimination of multiple proteins
Authors: Xu Shenghao , Wu Yufeng , Sun Xiaomei , Wang Zhuqing , Luo Xiliang
Published: April 2017

An easily accessible and potentially powerful effective cross-reactive sensor array based on six kinds of fluorescent Au NCs for discriminating multiple proteins according to the diverse fluorescence intensity response patterns was developed.
Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging
Authors: Zhao Shaojing , Niu Guangle , Wu Feng , Yan Li , Zhang Hongyan , Zhao Junfang , Zeng Lintao , Lan Minhuan
Published: April 2017

Polythiophene nanoparticles with large TPA cross section and high1O2generation quantum yield have been developed for simultaneous lysosome-targetable fluorescence imaging and photodynamic therapy.
Polypyrrole-interface-functionalized nano-magnetite epoxy nanocomposites as electromagnetic wave absorbers with enhanced flame retardancy
Authors: Guo Jiang , Song Haixiang , Liu Hu , Luo Chunjia , Ren Yanrong , Ding Tao , Khan Mojammel A. , Young David P. , Liu Xinyu , Zhang Xin , Kong Jie , Guo Zhanhu
Published: April 2017

Polypyrrole coated Fe3O4 nanoparticles have effectively enhanced the EMI shielding of epoxy nanocomposites compared with the physically mixed nanofillers.
Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications
Authors: Zheng Jia , Zheng Sheng , Feng Qianyun , Zhang Qian , Xiao Xinhua
Published: April 2017

Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity treatments are urgently warranted, which should be effective, safe, and widely available. Active compounds isolated from herbs are similar with the practice of Traditional Chinese Medicine, which has a holistic approach that can target to several organs and tissues in the whole body. Capsaicin, a major active compound from chili peppers, has been clearly demonstrated for its numerous beneficial roles in health. In this review, we will focus on the less highlighted aspect, in particular how dietary chili peppers and capsaicin consumption reduce body weight and its potential mechanisms of its anti-obesity effects. With the widespread pandemic of overweight and obesity, the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding of the role and mechanism of dietary capsaicin consumption and metabolic health can provide critical implications for the early prevention and treatment of obesity.
Hybrid teaching–learning‐based PSO for trajectory optimisation
Authors: Wang Hongfei , Li Yongwei
Published: April 2017

A hybrid modified teaching–learning‐based particle swarm optimisation (HMTL‐PSO) initialised by the normalised step cost (NSC), named HMTL‐NSCPSO, is proposed for solving trajectory optimisation with complex constraint problems. Specially, the new HMTL‐NSCPSO combines the canonical PSO basic policy, the teaching–learning‐based optimisation (TLBO) algorithm and the normalised step cost (NSC) function in order to promote diversity, obtain well‐speed convergence and to improve search ability. The algorithm is tested on an UAV trajectory optimization problems. Experimental results validate the effectiveness of the HMTL‐NSCPSO.
Design of absorptive superconducting filter
Authors: Ma Pnegyu , Wei Bin , Heng Yong , Luo Chenjie , Guo Xubo , Cao Bisong
Published: April 2017

An n‐pole absorptive reciprocal filter consists of at least 2n single‐mode resonators is proved. An absorptive band‐pass filter with four‐pole Chebyshev response is designed with two four‐pole filters and two‐quadrature hybrids. The quadrature hybrids are used to divide the signals into two paths. Additional two ports are introduced to absorb the reflected energy. This circuit structure is easy in fabrication on superconducting wafers. The filter is successfully designed and fabricated on an MgO substrate. The measured results match well with the simulations.
Application of the voltage control mode for second‐generation EAST active feedback power supply
Authors: Huang Haihong , Bi Nanxia , Wang Haixin
Published: April 2017

To achieve the maximum current rising rate, second‐generation Experimental Advanced Superconducting Tokamak (EAST) plasma vertical displacement active feedback power supply applies voltage control mode while retaining the first‐generation current tracking mode. When the power supply outputs high voltage, the accompanied frequent over‐current protection will return the power to DC side, which leads to over‐voltage protection, so the current limiting protection is applied. Experimental results prove that the voltage mode can greatly improve the ability to suppress vertical unstable displacement of plasma.
Simplified model predictive control with variable weighting factor for current ripple reduction
Authors: Abbaszadeh Alireza , Khaburi Davood Arab , Mahmoudi Hamid , Rodríguez José
Published: April 2017

Finite control set model predictive control evaluates a predefined cost function for each switching state of power converter. In addition to reference tracking term, cost function can include a term for switching frequency reduction. Small value for the weighting factor of switching reduction term cannot reduce switching frequency effectively and the great value results in reference tracking failure and increase current ripple. In this study a variable weighting factor based on current ripple is obtained and applied to the cost function. The value of weighting factor changes with the position and magnitude of reference voltage. Simulation and experimental results verify the effectiveness of proposed method.
Video-Assisted Thoracic Surgical Right Upper Lobectomy with Bronchus-First and Simultaneous Vessel Stapling Technique
Authors: Zhang Linyou , Xu Hao
Published: April 2017

A method of video-assisted thoracic surgical (VATS) right upper lobectomy with bronchus-first and simultaneous vessel stapling will be introduced. In this study, all cases underwent two-port VATS as follows: first, the right upper lobe bronchus was identified and stapled; then, all right upper lobe vessels were stapled simultaneously. This method was performed in 50 cases. There was no surgical mortality, hemorrhage, vascular injuries, or conversion. This technique can reduce wound size and operative time and make the operation safer and easier to accomplish.
Geometrical eigen-subspace framework based molecular conformation representation for efficient structure recognition and comparison
Authors: Li Xiao-Tian , Yang Xiao-Bao , Zhao Yu-Jun
Published: April 2017

We have developed an extended distance matrix approach to study the molecular geometric configuration through spectral decomposition. It is shown that the positions of all atoms in the eigen-space can be specified precisely by their eigen-coordinates, while the refined atomic eigen-subspace projection array adopted in our approach is demonstrated to be a competent invariant in structure comparison. Furthermore, a visual eigen-subspace projection function (EPF) is derived to characterize the surrounding configuration of an atom naturally. A complete set of atomic EPFs constitute an intrinsic representation of molecular conformation, based on which the interatomic EPF distance and intermolecular EPF distance can be reasonably defined. Exemplified with a few cases, the intermolecular EPF distance shows exceptional rationality and efficiency in structure recognition and comparison.
Capturing ultrafast magnetic dynamics by time-resolved soft x-ray magnetic circular dichroism
Authors: Takubo Kou , Yamamoto Kohei , Hirata Yasuyuki , Yokoyama Yuichi , Kubota Yuya , Yamamoto Shingo , Yamamoto Susumu , Matsuda Iwao , Shin Shik , Seki Takeshi , Takanashi Koki , Wadati Hiroki
Published: April 2017

Experiments of time-resolved x-ray magnetic circular dichroism (Tr-XMCD) and resonant x-ray scattering at a beamline BL07LSU in SPring-8 with a time-resolution of under 50 ps are presented. A micro-channel plate is utilized for the Tr-XMCD measurements at nearly normal incidence in both the partial electron and total fluorescence yield (PEY and TFY) modes at the L2,3 absorption edges of the 3d transition-metals in the soft x-ray region. The ultrafast photo-induced demagnetization within 50 ps is observed on the dynamics of a magnetic material of FePt thin films, having a distinct threshold of the photon density. The spectrum in the PEY mode is less-distorted at both the L2,3 edges compared with that in the TFY mode and has the potential to apply the sum rule analysis for XMCD spectra in pump-probed experiments.
Remote sub-wavelength focusing of ultrasonically activated Lorentz current
Authors: Rekhi Angad S. , Arbabian Amin
Published: April 2017

We propose the use of a combination of ultrasonic and magnetic fields in conductive media for the creation of RF electrical current via the Lorentz force, in order to achieve current generation with extreme sub-wavelength resolution at large depth. We demonstrate the modeling, generation, and measurement of Lorentz current in a conductive solution and show that this current can be localized at a distance of 13 cm from the ultrasonic source to a region about three orders of magnitude smaller than the corresponding wavelength of electromagnetic waves at the same operation frequency. Our results exhibit greater depth, tighter localization, and closer agreement with prediction than previous work on the measurement of Lorentz current in a solution of homogeneous conductivity. The proposed method of RF current excitation overcomes the trade-off between focusing and propagation that is fundamental in the use of RF electromagnetic excitation alone and has the potential to improve localization and depth of operation for RF current-based biomedical applications.