bluuebunny/crossref_metadata_2025 huggingface dataset:
FINANCIAL ANALYSIS OF THE RATING OF AGRICULTURAL DEVELOPMENT OF THE REGIONS OF UKRAINE
Authors: KOVAL Nataliia , RADCHENKO Oksana
Published: November 2022

The article is devoted to the study of the agrarian development of the regions of Ukraine by the methods of financial analysis. The features of the formation of the information base of financial analysis for the implementation of high-quality data processing are reflected. The latter include indicators of the production and financial activities of the agrarian sector of the economy in terms of the structure of industries, productivity indicators, the efficiency of agricultural activities, and fiscal budgetary levers for the formation of financial resources in the region. For the rating assessment of the agrarian development of the regions, the algorithm of the index method was used, in which the ratio (index) of each indicator of the region with the average value for Ukraine by groups of indicators is estimated. The integral production index was calculated for a group of indicators of productivity and wages, production costs. It is determined that according to the statistics of 2018-2020 the rating of agrarian development of the regions of Ukraine according to certain indicators is headed by Cherkasy, Vinnytsia and Kyiv regions. In order to deepen the methodology of financial analysis, a group of performance indicators for supporting agricultural production from local budgets and lending with the participation of the state, as well as payments from the Regional Development Fund was used to calculate the integral index of financial support in a time lag close to the first integral index. The rating in terms of support indicators is headed by Chernivtsi, Transcarpathian and Ivano-Frankivsk regions. The comparison of ratings in terms of production and financial support of the regions of Ukraine made it possible to reveal the trend that the regions with the most unstable production are better financed, with a certain dependence on the number of farms and their land area, in particular, in the terms of lending volumes. This is probably the Pareto principle, according to which 20% of regions receive 80% of funding. The selection of indicators for the purposes of financial analysis is confirmed by a significant degree of probability and corresponds to the hypothesis put forward about the statistical relationship between state financial support and the state of the agrarian economy of the regions of Ukraine. It has been established that the financial analysis is a powerful tool for forecasting and choosing management options at the level of agrarian development policy in the regions of Ukraine and requires expanding the methodology for its implementation. Modern products of attracting IT-technologies for financial analysis are described. The practical value of the study lies in expanding the indicators of the index method for the purposes of financial analysis of agricultural development at the regional level and clarifying its methodological components in the context of digitalization of the economy.
CURRENT PROBLEMS OF LAND RELATIONS IN THE CONDITIONS OF MARTIAL LAW AND WAYS TO SOLVE THEM
Authors: GKALETNIK Grygorii , TOMLYAK Taisa
Published: November 2022

The article examines the organization of land relations in conditions of martial law. The authors analyze the current land legislation adopted by the Parliament of Ukraine under martial law, give proposals for amendments to the Land Code of Ukraine and the Law of Ukraine «On Land Lease» to improve the mechanism of renewal of land lease in conditions of martial law, aimed to protect the rights of tenants and landlord, reducing the amount of payment for land of all forms of ownership and rent for land of state and communal ownership for the period of martial law.
The article also states that the authors’ proposed changes to the current land and tax legislation will provide the greatest possibility of agricultural land cultivation in wartime conditions, which will contribute to the intensive production of agricultural products.
The authors investigated that some legislative changes in land legislation adopted after February 24, 2022 need to be improved and changed, as they create legal uncertainty and multiple interpretations of legal norms. For example, the authors substantiate that public authorities and local governments cannot be the subject of the right of permanent use of state and communal land, as they are the administrators of such land.
The article concludes that the functioning of the State Register of Real Property Rights and the State Land Cadaster depends on the implementation of land relations, both individuals and legal entities of private law and public authorities and local governments.
The authors also found that in fact the legislator gave the right to permanent users to dispose of land plots of state and communal ownership, which directly contradicts Part 1 of Article 92 of the Land Code of Ukraine.
The important point is the forecast of lack of the local budgets of the rent for land in those territories where hostilities are (were) taking place, as well as the author's conclusion on the need to reduce the rent for land for the period of martial law throughout the whole territory of the state.
INTERNATIONAL EXPERIENCE OF STATE SUPPORT OF ENTREPRENEURSHIP IN THE AGRICULTURAL SECTOR OF THE ECONOMY
Authors: SAKHNO Andrii , DOTSIUK Svitlana
Published: November 2022

The article highlights the theoretical essence of state support for entrepreneurship and reveals the views of domestic scientists regarding this term. The forms and methods of state support that contribute to the effective development of production are reflected. The dynamics of changes in the volume of receipts of financial state support to the agricultural sector of the economy in Ukraine over the past five years have been analyzed, which indicates a decrease in the amount of financial support. The rating of the regions of Ukraine that received financial state support in the field of animal husbandry for 2021 and spent the compensation provided to them to increase the competitiveness of their economic activities is shown. An overview of the components of the state support program in 2022 is presented and the amounts of their compensation, which will be provided for the purchase of equipment, agricultural machinery, materials, certification of organic production, lending, etc., are indicated. The work also mentions measures of state support in Ukraine during the period of martial law during the sowing campaign.
The international experience of countries that consider agriculture as a strategically important industry for their country’s economy is taken into account. Agricultural crops for the cultivation of which subsidies are given to farmers in the United States and the states that received the most farm subsidies in the last five years are considered. The conditions under which people engaged in farming can receive government subsidies in Austria have been analyzed. It was concluded that the state support of the federal government of Germany is the most influential in the development of agricultural production compared to the experience of other European countries, in terms of timely bringing agricultural land to a high-quality state, preserving flora and fauna, complying with requirements for the identification and registration of livestock, bringing production to standards, hygiene and food safety, etc.
Pengembangan Desain Tikar sebagai Daya Tarik Wisatawan di Pantai Parangtritis
Authors: Purwanto Purwanto
Published: November 2022

Pantai Parangtritis merupakan salah satu objek wisata yang menjadi destinasi utama bagi wisatawan domestik  dan  wisatawan manca negara. Objek wisata ini  terletak di selatan provinsi D.I Yogyakarta yang berjarak 26 km atau 45 menit dari pusat kota Yogyakarta. Di lokasi ini, pengunjung bisa duduk santai di tepi pantai menggunakan tikar dan payung. Berdasarkan hasil pengamatan, sarana tersebut menjadi ciri khas Pantai Parangtris. Adapun beberapa hal yang menjadi kendala dan berdampak kepada pengunjung selaku penyewa dan pedagang selaku pemilik, yaitu saat angin bertiup kencang menyebabkan tikar tersingkap dan kotor.  Selain itu, pemberat yang digunakan terkesan seadanya berupa bongkahan batu bangunan, botol bekas berisi plastik dan kantong plastik berisi pasir. Penelitian ini dilakukan untuk menghasilkan beberapa alternatif desain yang dapat menyelesaikan permasalahan tersebut untuk meningkatkan daya tarik wisatawan di lokasi tersebut.  Metode yang digunakan dalam penelitian ini adalah kualitaitf non-partisipatori dengan pengambilan data berdasarkan hasil survey dan studi literatur. Proses perancangan dilakukan menggunakan morphological chart yang terbagi ke dalam beberapa kebutuhan, yaitu untuk penerangan, penampungan sampah sementara dan penandaan kepemilikan tikar. Alternatif desain disajikan dalam bentuk visual dan deskripsi implementasi. Hasil penelitian menunjukan penyelesaian masalah melalui beberapa altenatif desain tikar sekaligus  menciptakan suasana baru sebagai daya tarik objek wisata. Desain tikar yang dihasilkan dilengkapi dengan pemberat berupa tempat sampah sementara, lampu penerangan dan pemberian warna yang erbeda untuk tanda kepemilikan tikar.
Role of mitochondria in brain functions and related disorders
Authors: Yadav Monu , Dahiya Mini , Dagar Jyoti , Singh Narender , Sharma Nidhi , Rawat Nitin , Dhakla Pratibha , Minocha Neha , Kumar Anil
Published: November 2022

Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophysiology of mental problems. It has been observed that several drug types used to treat brain illnesses can harm mitochondria by altering the oxidative phosphorylation system and the gene expression of mitochondria-related proteins. In some studies, it has been observed that mitochondrial biogenesis shows a therapeutic effect in the management of mitochondrial disorders. Many therapeutic compounds are effective in the activation of mitochondrial biogenesis. The comorbidity of mental problems observed in those with mitochondrial dysfunction and the change in the efficacy of the cellular respiratory system have attracted researchers to understand the pathways and possible therapeutic strategies in neurological disorders. This article has attempted to understand the impact of mitochondrial function and mitochondrial dysfunction in the pathogenesis of brain disorders to develop potential therapeutic drugs.
Overview of biomarkers in myasthenia gravis
Authors: Afrashteh Fatemeh , Rajabi Rayan
Published: November 2022

Myasthenia gravis (MG) is a rare auto-immune neuromuscular junction (NMJ) disorder which is caused by formation of autoantibodies and destruction of NMJ components. The MG diagnosis is based on the symptoms, autoantibodies detection and paraclinical tests. Given that MG patients have so many differential diagnosis and various medication responses, choosing an accurate diagnosis and the therapy plan in MG is challenging. According to the studies, there are the immunologic, genetic, microRNAs, gut microbiome, and other established or newly proposed biomarkers for diagnosis and prognosis of MG. More studies are needed to provide better collection of biomarkers in MG patients and evaluate their role in MG pathology.
Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight
Authors: Kumar Ajay , Attri Shivani , Kaur Sandeep , Tuli Hardeep Singh , Saini Reena V. , Saini Adesh Kumar , Kumar Manoj , Kaur Satwinderjeet
Published: November 2022

Onosma (O.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments. The bioactive constituents present in the genus O. include benzoquinones, naphthazarins, alkaloids, phenolic, naphthoquinones, and flavonoids whereas shikonins and onosmins are the most significant. The review compiled contemporary research on O. L., including its distribution, morphology, traditional applications, phytochemistry, ethnopharmacology, and toxicology. This review also highlights a few critical challenges and possible future directions for O. L. research. Modern research has demonstrated a wide range of pharmacological effects of different species of O. L., including anti-diabetic, anticancer, anti-inflammatory, and cardiovascular protective. However, the studies on the O. genus are still not fully explored, therefore, researchers need to discover novel products with their toxicity studies, molecular mechanism, and associated side effects. Future exploration of potent constituents from this genus and clinical trials are required to explore its pharmacological importance.
Effect of Female Entrepreneurial Experience on Start-Ups of Educational Institutions: An Empirical Study of North-Central Nigeria
Authors: Nnebuife Ngele Anthonia , Lamino Abubakar Hauwa , May Nwoye , Daniel Cross Ogohi
Published: November 2022

This study evinced the cruciality of female entrepreneurial experience as a gainful propeller of start-up educational institutions in North-Central Nigeria. The focal aim of this study is to ascertain the effect of female entrepreneurial experience on start-ups specifically in the educational sector, which over the years recorded a tremendous influx of female entrepreneurs. A descriptive research design was adopted as the framework for this study and the population of the study comprised 43,470 female educators within the North-Central region of Nigeria. The Cochran sample size determination technique was used to obtain the sample size of 385 respondents. Bowley's allocation formula was adopted to determine the sample size of each North-Central state while simple random and purposive sampling was used to select participants. The questionnaires were structured in a 5-point Likert scale as a validity and reliability test was conducted to ensure their credibility. Data retrieved were analyzed using descriptive and inferential statistics via the aid of the Statistical Package for Social Sciences (SPSS) version 25 statistical tool. The results of the regression analysis validated the data at a 0.05 significance level. The findings revealed that socio-cultural expectations, exceptional economic support, social networking, innovation, and self-efficacy have a significant effect on the growth of educational institutions in North-Central Nigeria. Hence the study concludes that female entrepreneurial experience adversely affects the growth of educational institutions and start-ups in North-Central Nigeria. The study recommends that good government policies geared towards equal support of female entrepreneurs as endorsed by the liberal view of the feminist-based entrepreneurship theory.
Attitudes and Awareness Towards Cosmetic Surgery Among College Students in Kuwait
Authors: Al- Rifaai Jenan , Alfowzan Nadiah Abdulrazak
Published: November 2022

Cosmetic surgery is a very popular procedure performed nowadays with a significant increase around the world, having a dramatic and profound impact on student’s health and attitude. The aim of this study is to examine the attitude and level of awareness among students at the college of Health Science’s, which is under PAAET (The Public Authority for Applied Education & training) towards cosmetic surgery and the risks taken behind these procedures. Questionnaires were administered to 250 college students that were analyzed using SPSS version (25). Result showed that female students had more cosmetic surgeries performed than male students, having a positive attitude towards cosmetic surgery, neglecting the risks of these surgeries. This study showed that media and friends have a great impact on the attitude of the students towards cosmetic surgery. Further studies should be undertaken to investigate the attitude of a wider population beyond colleges and universities towards these surgeries.
Human Genome & Origin of Mitochondria
Authors: Eriso⃰ Feleke
Published: November 2022

It had been believed that when individual eukaryotic cells engulfed aerobic and photosynthetic bacteria, the bacteria became endosymbionts with the phagocyte and evolved into mitochondria and chloroplasts respectively. The key objective of this study is to prove that the Endosymbiotic Theqory about the origins of mitochondria and chloroplasts is a misleading lie, being ridiculously laughable. Each of the micrographs or videos in the Figures, and each of the concrete evidences listed were designed to have targetful aims. The micrographs, videos, and concrete evidences were devised to serve as addressive findings (results). The human mitochondrial DNA is a transcript obtained when two separate spliced or mature RNAs (of DNA type) transcribed from the nuclear Genome of human oocyte have annealed into double-stranded transcript and exported into the cytoplasmic organelle called mitochondrion (plural, mitochondria) that mainly performs the task of producing energy (ATP) to power the genomic reactions of the cell. Lynn Margulis’s Endosymbiotic Theory which stated that mitochondrion & chloroplast found in eukaryotic cells had evolved from bacteria when they were engulfed by eukaryotic cells, was a misleading lie that would had been ridiculously laughable!!!!
PROFIL PENGGUNAAN ANTIBIOTIK PADA KONSUMEN DI APOTEK “X“ TAHUN 2020
Authors: Markhamatul Aeni  , Ikanah Wulandari  , Aan Kunaedi  , Tomi  , Hapsari Dinda Alifia
Published: November 2022

Antibiotik kini sudah tidak asing lagi bagi masyarakat dimana antibiotik memiliki fungsi untuk membunuh atau menghambat pertumbuhan bakteri. Antibiotik biasanya diresepkan oleh dokter ketika pasien tersebut menderita keluhan infeksi yang disebabkan oleh bakteri, namun saat ini masyarakat sangat mudah mendapatkan antibiotik tanpa menggunakan resep. Antibiotik memiliki berbagai macam jenis, dosis , sediaan serta fungsi yang berbeda-beda jika jenis antibiotik dan dosis yang digunakan tidak sesuai dengan keluhan penyakit yang diderita oleh pasien maka dapat menyebabkan Resistensi Antibiotik. Penelitian ini dilakukan di Apotek “X” pada bulan Mei 2021. Data yang digunakan adalah data yang diperoleh dari penjualan atau transaksi obat antibiotik periode Januari 2020 – Desember 2020. Penelitian ini dilakukan secara non eksperimental dengan metode yang digunakan adalah metode deskriptif dan pengambilan data dilakukan secara retrospektif. Data penjualan obat Antibiotik periode Januari 2020 – Desember 2020 berdasarkan pola penggunaan resep yaitu 538 transaksi sebanyak 21% sedangkan pola penggunaan non resep yaitu 2048 transaksi sebanyak 79%. Berdasarkan golongan antibiotik yang banyak digunakan adalah golongan antibiotik Penicilin yaitu Amoxycyclin dengan kekuatan dosis 500mg dan sediaan Kaplet.
Development of Smart Factory Abnormal Detection Method Using Object Detection and AutoEncoder
Authors:   Academic Society of Global Business Administration, Kno Younsik , Jeong Kwangpil , Kweon Junoh , Cho Insu , Ju Yonghan
Published: November 2022

Recently, artificial intelligence algorithms are being applied in various industrial fields. Under these circumstances, the manufacturing industry is also conducting research on artificial intelligence in areas such as classification, prediction, and monitoring. However, it is not easy for SMEs to invest in new areas such as artificial intelligence. Therefore, this study proposes an image-based process management system for the manufacturing system. In this paper, We utilize the object detection algorithms YOLOV5 and autoencoder in the direction of process anomaly detection. First, the object is extracted in real time from the information of the image taken at the mobile device level through the YOLOv5. Next, the extracted image is defined as an input value of the autoencoder, and a main feature is to be extracted. In particular, the performance of object detection was compared through scenario analysis and the amount of data required for learning. It is expected that the abnormality detection methodology presented in this study will contribute to the purpose of establishing a smart factory and improving productivity and yield of domestic manufactured SMEs.
¿ La Coordinación intergubernamental es suficiente para construir una gobernanza en América Latina ? El caso de México
Authors: Arenas Juan Ángel Demerutis
Published: November 2022

Aborda o panorama do processo de metropolização no México, por meio da literatura mexicana sobre o desenvolvimento de políticas públicas para o planejamento urbano, analisa o marco legal da questão metropolitana e apresenta um estudo de caso sobre a área metropolitana de Guadalajara.
Venezuela : da descentralización imperfecta a la centralización absoluta
Authors: Cardona Ignacio , Schloeter Luis , Troconis Carlos Urdaneta
Published: November 2022

Faz uma análise histórica do processo de descentralização, com ênfase na governança metropolitana, no caso venezuelano. É um processo historicamente marcado entre a estrutura legal que define a República como Estado federal versus o poder onipotente do Estado centralizado.
Desde la regionalización a la gobernanza metropolitana : el caso de Santiago de Chile
Authors: Flores Pablo Fuentes , Caimanque Rodrigo , Vicencio Karen Martínez
Published: November 2022

Apresenta o contexto geral da governança metropolitana no chile destacando uma série de momentos bastante prospectivos. Esses cenários, no entanto, foram se cruzando com os atuais mecanismos em uso, vinculados à escala regional e metropolitana, a partir de aspectos legislativos, de seus instrumentos de planejamento do território, bem como dos atuais mecanismos de financiamento.
Gobernanza metropolitana en Colombia y su aplicación en el caso del Valle de Aburrá
Authors: Salamanca Julio Miguel Silva , Bonilla Manuel Guillermo
Published: November 2022

Apresenta os principais elementos de natureza jurídica em torno da constituição das áreas metropolitanas na Colômbia. Descreve a evolução normativa relacionada à constituição da área metropolitana e os requisitos estabelecidos para sua formulação. Expõe o conceito de área metropolitana contido no regulamento atual, bem como o objeto e a natureza legal desta, a fim de descrever as instâncias dos governos locais nos quais o poder de constituir uma área metropolitana está concentrado.
Distritos metropolitanos en Ecuador : un proceso inconcluso
Authors: Rodríguez Egüez Vanessa
Published: November 2022

Revisa a evolução do arcabouço jurídico-institucional relacionado aos DMs (Regime Especial de Governo do Nível Cantonal), sua caracterização, o processo e os desafios para sua formação, as competências atribuídas e suas fontes de financiamento. No final, é analisado o caso de Quito e seu caminho para se consolidar como o único DM5 do país.
Lima metropolitana : competencia, coordinación y fragmentación institucional
Authors: Dammert-Guardia Manuel
Published: November 2022

Descreve as dimensões institucionais e regulatórias da governança metropolitana em Lima (Peru), caracterizada por sua alta fragmentação, competição entre níveis de governo e baixos níveis de cooperação nas relações horizontais e verticais entre os níveis de governo envolvidos no gerenciamento de uma metrópole como Lima, capital do Peru.
O Planejamento metropolitano na região metropolitana de Belo Horizonte : o dia seguinte
Authors: Drummond Maria Valeska Duarte
Published: November 2022

Este capítulo se atém à atuação da Agência de Desenvolvimento da Região Metropolitana de Belo Horizonte (Agência RMBH) após a conclusão do Plano Diretor de Desenvolvimento Integrado (PDDI) da Região Metropolitana de Belo Horizonte (RM de Belo Horizonte), que corresponde ao Plano de Desenvolvimento Urbano Integrado (PDUI) previsto no Estatuto da Metrópole, até outubro de 2019. O PDDI foi aprovado nas instâncias deliberativas previstas no arranjo da região metropolitana (RM), encaminhado à Assembleia Legislativa em 2017 e arquivado com a mudança da legislatura.
O Plano estratégico de desenvolvimento urbano integrado da região metropolitana do Rio de Janeiro : entre avanços e impasses
Authors: Martins Luis Gustavo Vieira
Published: November 2022

Este capítulo tem o objetivo de resgatar a memória do processo de elaboração do Plano Estratégico de Desenvolvimento Urbano Integrado (PEDUI) da Região Metropolitana do Rio de Janeiro (RM do Rio de Janeiro) e do contexto em que o plano foi elaborado, e realizar uma breve avaliação sobre seus principais aspectos, contemplando as soluções de governança, a definição dos instrumentos, os arranjos de gestão e a solução de conflitos de uso e ocupação do solo.
Região metropolitana do Vale do Rio Cuiabá : em busca de respostas ao estatuto da metrópole
Authors: Lopes Alberto Costa
Published: November 2022

Este trabalho constitui um relato sobre o ciclo de elaboração, aprovação e início da implementação do Plano Diretor de Desenvolvimento Integrado da Região Metropolitana do Vale do Rio Cuiabá (PDDI/RM do Vale do Rio Cuiabá), no estado de Mato Grosso, em atenção ao disposto no Estatuto da Metrópole (EM), de 2015. O período coberto vai de julho de 2016 até o início de 2020.
Os Desafios para o financiamento do desenvolvimento urbano-metropolitano : em que pé estamos e para onde vamos?
Authors: Martins Luis Gustavo Vieira , Costa Marco Aurélio
Published: November 2022

Este capítulo é produto do esforço coletivo de pesquisa que o Ipea vem coordenando em parceria com governos estaduais, instituições metropolitanas, institutos de pesquisa e universidades, ao longo dos últimos anos, com vistas a monitorar e avaliar a evolução das metrópoles brasileiras e o processo de instituição de regiões metropolitanas (RMs) no Brasil. Para além dos arranjos políticos, legais, institucionais e de planejamento e gestão, a questão do financiamento pode assumir um papel relevante para se avaliar a evolução do processo de institucionalização das RMs no país, dado que a viabilização efetiva dessa política demanda recursos para sua implementação.
Pengenalan dan Transformasi Diri dalam Kepemimpinan Kristen Berkarakter
Authors: Engel Jacob Daan
Published: November 2022

This research aims to understand a person's quality in Christian leadership. This research is motivated by the fact of being incapable of Christian leadership. This research uses library research to find the data through the literature and analysis. The finding is to introduce in self – transforming to be a measure for a unique Christian leader with the characters through social interaction, which is communication and relationship.
Faint Stars in a Faint Galaxy. II. The Low-mass Stellar Initial Mass Function of the Boötes I Ultrafaint Dwarf Spheroidal Galaxy
Authors: Filion Carrie , Platais Imants , Wyse Rosemary F. G. , Kozhurina-Platais Vera
Published: November 2022

This paper presents improved constraints on the low-mass stellar initial mass function (IMF) of the Boötes I (Boo I) ultrafaint dwarf galaxy, based on our analysis of recent deep imaging from the Hubble Space Telescope. The identification of candidate stellar members of Boo I in the photometric catalog produced from these data was achieved using a Bayesian approach, informed by complementary archival imaging data for the Hubble Ultra Deep Field. Additionally, the existence of earlier-epoch data for the fields in Boo I allowed us to derive proper motions for a subset of the sources and thus identify and remove likely Milky Way stars. We were also able to determine the absolute proper motion of Boo I, and our result is in agreement with, but completely independent of, the measurement(s) by Gaia. The best-fitting parameter values of three different forms of the low-mass IMF were then obtained through forward modeling of the color–magnitude data for likely Boo I member stars within an approximate Bayesian computation Markov Chain Monte Carlo algorithm. The best-fitting single power-law IMF slope is

α
=
−

1.95

−
0.28

+
0.32

, while the best-fitting broken power-law slopes are

α

1

=
−

1.67

−
0.57

+
0.48

and

α

2

=
−

2.57

−
1.04

+
0.93

. The best-fitting lognormal characteristic mass and width parameters are

M

c

=

0.17

−
0.11

+
0.05



⊙

and

σ
=

0.49

−
0.20

+
0.13

. These broken power-law and lognormal IMF parameters for Boo I are consistent with published results for the stars within the Milky Way, and thus it is plausible that Boötes I and the Milky Way are populated by the same stellar IMF.
New species and new records of semiaquatic bugs (Arthropoda, Insecta, Hemiptera, Heteroptera, Gerromorpha) from French Guiana
Authors: Rodrigues Juliana Mourão dos Santos , Crumière Antonin Jean Johan , Toubiana William , Khila Abderrahman , Moreira Felipe Ferraz Figueiredo
Published: November 2022

Semiaquatic bugs (Hemiptera: Heteroptera: Gerromorpha) are predatory insects that occupy a wide range of freshwater and marine habitats, with some secondary transitions to terrestrial life. They currently represent more than 2100 species distributed through all continents, except for Antarctica, and are especially rich in the Neotropical and Oriental regions. Although the fauna from the former region is relatively well known, some areas remain almost unexplored. Such is the case of French Guiana, where only a few species have been previously recorded, several of which based on collections made in the 19thand early 20thcenturies. As a result of material recently collected in the territory, the descriptions ofRhagovelia depressaRodrigues, Khila & Moreira,sp. nov.,R. tantilloidesRodrigues, Khila & Moreira,sp. nov.andSteinovelia vittataRodrigues, Khila & Moreira,sp. nov.(Veliidae) are presented here. New records for 28 species are also provided, of whichCylindrostethus hungerfordiDrake & Harris, 1934,Neogerris magnus(Kuitert, 1942),Rheumatobates mangrovensis(China, 1943),R. trinitatis(China, 1943),Ovatametra obesaKenaga, 1942,Telmatometra fuscaKenaga, 1941,T. parvaKenaga, 1941 (Gerridae),Mesovelia amoenaUhler, 1894 (Mesoveliidae),Rhagovelia brunaeMagalhães & Moreira, 2016,R. elegansUhler, 1894,R. ephydros(Drake & Van Doesburg, 1966),R. equatoriaD. Polhemus, 1997,R. evidisBacon, 1948,R. guiananaD. Polhemus, 1997,R. tenuipesChampion, 1898,Oiovelia cunucunumana(Drake & Maldonado-Capriles, 1952),Stridulivelia alia(Drake, 1957),S. stridulata(Hungerford, 1929), andS. tersa(Drake & Harris, 1941) (Veliidae) are reported from French Guiana for the first time.
How does the digital economy affect industrial eco-efficiency? Empirical evidence from China
Authors: Liu Lu , Liu Ming
Published: November 2022

Industry is a sector with large energy consumption and pollutant emissions. Improving industrial eco-efficiency is crucial to energy conservation and pollution reduction. The digital economy has developed rapidly in recent years. However, there is a lack of research on the specific relationship between the digital economy and industrial eco-efficiency. This study measured the industrial eco-efficiency of 30 provinces in China from 2010 to 2020, through a super-efficiency slack-based measure (SBM) considering desirable outputs. By constructing a two-way fixed effect model and a panel quantile model, this study explored the effects of the digital economy on industrial eco-efficiency on a national scale. Furthermore, this study conducted grouping regression and investigated the heterogeneous impacts of the digital economy on industrial eco-efficiency. Finally, this study built a spatial Durbin model to explore the spatial effects of digital economy on industrial eco-efficiency. According to the empirical results, this study yielded the following conclusions. First, the digital economy has a significantly positive effect on industrial eco-efficiency at the national scale, with diminishing marginal returns. Second, the effects of the digital economy on industrial eco-efficiency are significantly heterogeneous on a regional scale. For eastern regions, the effects of the digital economy on industrial eco-efficiency are significantly positive, while they are negative for western regions. Third, the spillover effect of the digital economy on industrial eco-efficiency is not significant in China, indicating that there is digital isolation.
Lagrangian–Hamiltonian formalism for cocontact systems
Authors: Rivas Xavier , Torres Daniel
Published: November 2022

In this paper we present a unified Lagrangian–Hamiltonian geometric formalism to describe time-dependent contact mechanical systems, based on the one first introduced by K. Kamimura and later formalized by R. Skinner and R. Rusk. This formalism is especially interesting when dealing with systems described by singular Lagrangians, since the second-order condition is recovered from the constraint algorithm. In order to illustrate this formulation, some relevant examples are described in full detail: the Duffing equation, an ascending particle with time-dependent mass and quadratic drag, and a charged particle in a stationary electric field with a time-dependent constraint.
Mechanical analyses of flat sheet water treatment membranes
Authors: Ozdemir Murat , Oterkus Selda , Oterkus Erkan , Amin Islam , El-Aassar Abdel-Hameed , Shawky Hosam
Published: November 2022

In this work, we address the mechanical response of the flat sheet polymeric water treatment membranes under the assumed operational loading conditions. Firstly, we perform quasi-static analyses of the membranes under normal pressure loads, which is the condition that resembles the actual loading for flat sheet membranes in the submerged membrane bioreactors. Then, the long-term deformation of the membranes is studied under the assumed filtration durations for the same loading conditions by utilizing the viscoelastic material models. The quasi-static and viscoelastic membrane simulations are performed by a commercial finite element code ANSYS. Finally, the mechanical fatigue life predictions are carried out based on the stress distributions from the quasi-static analyses and the long-term effects from the viscoelastic analyses.
Numerical analysis of fractional-order Whitham-Broer-Kaup equations with non-singular kernel operators
Authors: Al-Sawalha M. Mossa , Ababneh Osama Y. , Shah Rasool , khan Amjad , Nonlaopon Kamsing
Published: November 2022

This paper solves a fractional system of non-linear Whitham-Broer-Kaup equations using a natural decomposition technique with two fractional derivatives. Caputo-Fabrizio and Atangana-Baleanu fractional derivatives were applied in a Caputo-manner. In addition, the results of the suggested method are compared to those of well-known analytical techniques such as the Adomian decomposition technique, the Variation iteration method, and the optimal homotopy asymptotic method. Two non-linear problems are utilized to demonstrate the validity and accuracy of the proposed methods. The analytical solution is then utilized to test the accuracy and precision of the proposed methodologies. The acquired findings suggest that the method used is very precise, easy to implement, and effective for analyzing the nature of complex non-linear applied sciences.
Echocardiographic Prediction of Successful Weaning From Venoarterial Extracorporeal Membrane Oxygenation
Authors: Alonso-Fernandez-Gatta Marta , Merchan-Gomez Soraya , Gonzalez-Cebrian Miryam , Diego-Nieto Alejandro , Gonzalez-Martin Javier , Toranzo-Nieto Ines , Barrio Alfredo , Martin-Herrero Francisco , Sanchez Pedro L.
Published: November 2022

Background

Weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) support fails in 30% to 70% of patients.

Objective

To explore the utility of echocardiographic parameters in predicting successful disconnection from VA-ECMO.

Methods

Patients receiving VA-ECMO in a referral hospital were included. The relationships between echocardiographic parameters during the weaning trial and weaning success (survival > 24 hours after VA-ECMO explant and no death from cardiogenic shock, heart failure, or cardiac arrest during the hospital stay) and survival were evaluated.

Results

Of 85 patients included, 61% had successful weaning. Parameters significantly related to weaning success were higher left ventricular ejection fraction (LVEF; 40% in patients with weaning success vs 30% in patients with weaning failure, P = .01), left ventricular outflow tract velocity time integral (15 cm vs 11 cm, P = .01), aortic valve opening in every cycle (98% vs 91% of patients, P = .01), and normal qualitative right ventricular function (60% vs 42% of patients, P = .02). The LVEF remained as an independent predictor of weaning success (hazard ratio, 0.938; 95% CI, 0.888-0.991; P = .02). An LVEF >33.4% was the optimal cutoff value to discriminate patients with successful weaning (area under the curve, 0.808; sensitivity, 93%; specificity, 72%) and was related to higher survival at discharge (60% vs 20%, P < .001).

Conclusion

Among weaning trial echocardiographic parameters, LVEF was the only independent predictor of successful VA-ECMO weaning. An LVEF >33.4% was the optimal cutoff value to discriminate patients with successful weaning and was related to final survival.
Basal Ganglia Autoimmune Encephalitis Following Leptospirosis
Authors: Gowda Vykuntaraju K. , Gupta Priya , Shivappa Sanjay K. , Bhat Maya
Published: November 2022

Basal ganglia encephalitis is a part of the spectrum of autoimmune basal ganglia disorders. We are reporting a child who had a fever with focal seizures followed by behavioral problems, rigidity, bradykinesia, and dystonia. His parkinsonism-like features were increasing day by day up to the level that the child was non-ambulatory. His initial Magnetic Resonance Imaging (MRI) of the brain showed asymmetrical T2 hyperintensities involving both the caudate nuclei and putamina. Later, with progressive symptoms, repeat MRI revealed a swelling and symmetrical signal change in both the caudate nuclei and putamina in the form of T2 and Fluid-attenuated inversion recovery (FLAIR) hyperintensities. In addition, there was T2 hyperintensity involving bilateral substantia nigra. Serum basal ganglia antibody, Leptospira Immunoglobulin M (IgM) antibody was positive, and Cerebrospinal Fluid (CSF) oligoclonal band was positive. So, the child was diagnosed with post-leptospirosis autoimmune basal ganglia encephalitis. He was managed with immunomodulatory agents and significant improvement in the symptoms with mild residual extrapyramidal symptoms were noted.
Use of Fluoxetine to Augment the Inter-Ictal Hypercapnic Ventilatory Response in Patients with Epilepsy
Authors: Sainju Rup K , Dragon Deidre N , Winnike Harold B , Eyck Patrick Ten , Granner Mark A , Gehlbach Brian K , Richerson George B
Published: November 2022

Background:

Severe peri-ictal respiratory dysfunction is a potential biomarker for high SUDEP risk and correlates with an attenuated hypercapnic ventilatory response (HCVR). Prior studies suggest a potential role for selective serotonergic reuptake inhibitors in modifying the HCVR, but this approach has not been studied in the epilepsy population.

Objectives:

To assess the feasibility of using fluoxetine to augment HCVR in epilepsy patients.

Methods and Material:

An inter-ictal HCVR was measured using a CO2 rebreathing technique in patients with epilepsy aged 18–75 years. Eligible participants were randomized to fluoxetine or placebo, and the HCVR was repeated at the end of week 4. Primary outcomes were recruitment and retention rate.

Results:

Of the 30 subjects enrolled, 22 were randomized (mean: 3.8 subjects/3 months), with a retention rate of 100% in fluoxetine and 95% in placebo.

Conclusions:

Our results demonstrate feasibility for a larger definitive future study to assess the efficacy of fluoxetine in augmenting HCVR.
A Rare Triad of Lateral Rectus Palsy, Sylvain Fissure Bleed, and Bilateral SDH Shrouding a Benign Pathology
Authors: Meena Rajesh Kumar , Doddamani Ramesh S , Kanasani Suresh , Sawarkar Dattaraj P , Singh Pankaj Kumar , Chandra P Sarat
Published: November 2022

Background:

Arachnoid cysts are benign extra-cerebral congenital lesions that are thought to arise from the splitting of the arachnoid membrane. Although most arachnoid cysts remain static with advancing age, occasionally they can become symptomatic due to cyst enlargement or hemorrhage. Hemorrhage into the arachnoid cysts (intra-cystic hemorrhage) with or without associated subdural hematoma is of rare occurrence.

Case Discussion:

A 23-year-old male presented with a history of sudden onset severe headache while sleeping. The patient also noticed double vision, especially when looking towards the left side. Non-contrast computed tomography (NCCT) scan of the head showed left temporal pole hematoma with left Sylvian fissure bleed and bilateral fronto-temporoparietal (FTP) subacute SDH.

Conclusion:

Every patient with incidentally detected AC, especially in the middle cranial fossa, should be counseled regarding the risk of possible complications including hemorrhage and regular follow-up.
Basilar Artery Thrombectomy Between Evidence-Based Medicine and the Real-World Practice
Authors: El Malky Islam , Hendi Ali Mo , Abdelkhalek Hazem Mo
Published: November 2022

Background and Aim:

Basilar artery occlusion (BAO) is known for its catastrophic outcomes, whether death or disability, in approximately 70% of patients. Mechanical thrombectomy (MT) has been approved as an intervention in large vessel occlusion of anterior circulation, based on multiple randomized controlled trials (RCTs) and meta-analyses. Even though two RCTs appeared recently, there is still uncertainty about the effect of MT in BAO. Our study aims to report the outcome of MT in BAO and the variables affecting good outcomes and mortality rate.

Materials and Methods:

We retrospectively collected the clinical and radiological data of 30 BAO patients treated in our center by MT between July 2016 and July 2021. A favorable clinical outcome was considered if mRS was ≤2. A favorable radiological result was considered if modified Thrombolysis in Cerebral Infarction (mTICI) was ≥2b at the end of the intervention. Multiple variables were tested for their effects on favorable clinical outcomes and mortality.

Results:

The mean age of the 30 patients was 61.23 ± 16.81 years; 20/30 (66.7%) were male. A favorable functional outcome was achieved in 40.7%. Successful revascularization was achieved in 26 patients (86.7%). Mortality at 90 days was observed in 11 patients (36.7%). The presenting National Institute of Health and Stroke Scale (NIHSS) was the only predictor of mortality, and the optimal cut-off value for death was 15 with area under the curve (AUC) = 0.758 (sensitivity 91% and specificity 59%) andPvalue = 0.02.

Conclusion:

Thrombectomy is an effective procedure in BAO which has naturally a bad outcome. The presenting NIHSS might be the only predictor of mortality in our study.
Central Hypoventilation Following Pontomedullary Tumor Decompression – Is Routine Brainstem Monitoring Adequate?
Authors: Goyal Amit , Srinivasaiah Bharath , Kumar Mathangi K , Pallavi Kumari
Published: November 2022

Neurophysiological monitoring assesses the functional integrity of the brainstem by using monitoring and mapping techniques. We report an operated case of a pontomedullary lesion in a patient who developed central hypoventilation postoperatively. The intraoperative use of neurophysiological and cardiovascular monitoring was unable to predict/prevent this hypoventilation. We describe the inherent limitations of monitoring the respiratory system, including spontaneous respiration. Moreover, we suggest the novel application of diaphragmatic motor evoked potential for real-time monitoring of respiratory pathways during brainstem surgeries.
Diaphragmatic Flutter
Authors: Vaishakh Anand , Juhi Gupta , Sonali Singh , Prashant Jauhari , Manisha Jana , Biswaroop Chakrabarty , Sheffali Gulati
Published: November 2022

Diaphragmatic flutter (DF) is an unusual movement disorder with involuntary and repetitive contractions of the diaphragm with or without other abdominal muscle involvement. The disorder is known to occur across all ages including newborns. The etiology is diverse and so are the therapeutic options. Reaching an etiological diagnosis is considerably delayed. Response to therapy is variable and is governed by the underlying etiology. We describe three children with diaphragmatic flutter. The etiology was diverse with unrelated pathologies such as hypocalcemia, striatal necrosis, and idiopathic. All three children responded promptly and completely to calcium, high dose thiamine and biotin, and clonazepam, respectively. Our case series underscores the importance of clinical identification of such rare movement disorders. It also emphasizes that directed etiological evaluation may lead to successful amelioration of DF which is otherwise considered refractory to therapy.
Complexities in Genetic Counseling and Testing of Huntington's Disease
Authors: Ratna Nikhil , Pasupulati Swathi Lakshmi , Nadella Ravi K. , Purushottam Meera , Jain Sanjeev
Published: November 2022

Background:

Huntington's Disease (HD) is an autosomal dominant, progressive neuropsychiatric illness caused by CAG repeat expansion. The high penetrance of the mutation and limited treatment options make it challenging for patients and caretakers. Proper counseling enables families to cope better and make informed life choices.

Objective:

To explore some complex issues in genetic counseling and testing (GCAT) in HD.

Materials and Methods:

Vignettes of patients who underwent genetic testing along with pre and post-test counseling at our GCAT clinic.

Results:

Case 1: Diagnosis of juvenile HD meant that the healthy parent was an obligate carrier of the mutation. Case 2: Consanguinity resulted in a dense prevalence of HD and >50% risk for the progeny. Case 3: Predictive testing in youth with healthy parents but affected uncles and aunts revealed a HD expansion.

Conclusions:

HD can present with complex inheritance patterns and proper counseling is necessary for better outcomes.
COVID-19 and Stroke Trends in A Tertiary Care Center from South India -Our Monsoon Experience
Authors: Ramachandran Dileep , George Githin Benoy , Panicker Praveen , Aravind R , Suresh MK , Iype Thomas
Published: November 2022

Introduction:

The unprecedented challenges during the COVID pandemic and the subsequent lockdown had resulted in a delay in treatment metrics for acute stroke. There is a rising concern that COVID-19 co-infection can adversely affect stroke outcome. We aim to investigate the impact of COVID-19 in the management of stroke patients. We also compared the differences in stroke manifestations, etiological pattern, treatment course, and outcome of acute stroke patients in COVID-19 confirmed cases.

Methodology:

A single-center retrospective study was done at the Stroke Unit, Government Medical College, Thiruvananthapuram. Consecutive patients of acute stroke confirmed by imaging, presenting within 24 hours of the onset of symptoms in May to July 2020 and May to July 2019, were included. The primary data variables included baseline demographics, risk factors, admission NIHSS, stroke timings, thrombolysis rate, TOAST etiology, mRS at discharge, and in-hospital mortality.

Results:

Strokes with higher NIHSS, arrival blood sugar and blood pressure, and delays in door-to-CT and door-to-needle time were more during the pandemic. Intravenous thrombolysis was less and mortality was higher in COVID-19 strokes during the pandemic. COVID-19-positive stroke patients had more hemorrhagic strokes, more severe strokes with low CT ASPECTS, more hemorrhagic transformation, high in-hospital mortality, and poor functional outcome at discharge and 3 months.

Conclusion:

Our study was a hypothesis-generating study with a limited number of patients. This study has reconfirmed the higher severity of the stroke, with a higher mRS score and mortality during the pandemic, especially among COVID-19-positive stroke patients.