bluuebunny/crossref_metadata_2025 huggingface dataset:
Addressing Emerging Needs Through the COVID-19 and Children With Medical Complexity ECHO
Authors: Boothby Christina , Lail Jennifer , Agrawal Rishi , Corcoran Peter , Comeau Meg
Published: January 2024

The COVID-19 and Children with Medical Complexity (CMC) Extension for Community Healthcare Outcomes (ECHO) was developed as a “just in time” learning format to respond to the vast number of challenges faced by health care clinicians, public health professionals, and families/caregivers of CMC during the coronavirus disease 2019 (COVID-19) pandemic. A unique aspect of the ECHO was the meaningful integration of family leaders who participated as faculty, learners, case study presenters, and guest lecturers. Another distinguishing feature of this ECHO was its inclusion within a Collaborative Improvement and Innovation Network. A mixed methods analysis found that the COVID-19 and CMC ECHO was associated with significant gains in knowledge and confidence in caring for CMC and their families during the COVID-19 pandemic. This article provides an overview of the results of the COVID-19 and CMC ECHO and provides recommendations related to utilizing the ECHO model as a rapid response mechanism for systems improvement, clinical practice improvement, and education during a public health emergency.
Objeção de consciência médica em casos de abortamento
Authors: Ferruzzi Sacchetin Letícia , Pereira de Souza Andressa , Santina Murgo Camelia
Published: January 2024

Introdução: a objeção de consciência possibilita assegurar direitos médicos, mas é um entrave para a saúde pública no Brasil. Objetivo: realizar uma revisão de literatura brasileira avaliando a motivação por parte dos profissionais da saúde que apresentam objeção de consciência em casos de abortamento legalizados. Método: para tanto, realizou-se uma revisão de literatura brasileira PICO, com a pergunta norteadora: ensino tecnicista médico versus religiosidade interferem na opção para a objeção de consciência diante do abortamento legalizado? Utilizou-se as bases: Cochrane Library, Lilacs, PubMed, Scielo e Periódicos CAPES, contando com os descritores “(Objeção de Consciência)”; “(Objeção de Consciência) AND (Religião)”; “(Objeção de Consciência) AND (Educação Médica)”; “(Objeção de Consciência) AND (Religião) AND (Educação Médica)” e seus respectivos termos em inglês acrescidos do termo “abortion”. A busca foi realizada em janeiro de 2023 e limitada ao período entre 2016 e 2023. Resultado: a busca inicial resultou em 1746 artigos, sendo desses apenas 17 incluídos. Pode-se observar que a religião é uma influência, contudo, a falta da temática nas faculdades de Medicina faz com que os médicos procedam de forma incorreta ou incompleta ao objetarem a consciência. Conclusões: este estudo servirá para futuros projetos de intervenção com acadêmicos de Medicina, que minimizem o entrave no acesso ao aborto.
La experiencia de enseñanza del francés en personas adultas y adultas mayores participantes del Programa Institucional de la Persona Adulta y Adulta Mayor (PIAM) de la Universidad de Costa Rica (UCR)
Authors: Sánchez Ulate Amanda
Published: January 2024

Con frecuencia escuchamos que la mejor edad para aprender una lengua extranjera es la infancia. Esto crea el prejuicio de que al intentarlo más adelante en la vida ya será tarde. El Programa Institucional de la Persona Adulta y Adulta Mayor (PIAM) de la Universidad de Costa Rica (UCR) ofrece una serie de cursos en lengua francesa que permite al estudiantado en este idioma, disfrutar del proceso de enseñanza-aprendizaje, reducir el estigma etario y fortalecer su experiencia de envejecimiento saludable. Esta ponencia permite conocer sobre la oferta de cursos y las distintas fortalezas y desafíos que suceden dentro y fuera de las aulas de lengua francesa del PIAM
Estrategias neuroeducativas: camino para mejorar la actitud y metacognición en estudiantes universitarios
Authors: González Cabrera Silvia Yunuén , Pinto Rodríguez Noemí Alejandra
Published: January 2024

Este artículo es una aproximación teórica a las estrategias neuroeducativas, como posible camino, para favorecer la actitud frente al estudio y desarrollar habilidades metacognitivas en estudiantes universitarios. Diversos estudios han constatado, que una variable relevante, para generar una actitud positiva y desarrollar habilidades metacognitivas en estudiantes universitarios, es el método de enseñanza del profesor. Una de las ciencias que favorece los procesos educativos, es la neuroeducación, ya que a pesar de ser una ciencia relativamente nueva y que varias de sus teorías siguen en investigación, presenta datos significativos sobre el estudio del cerebro, sus procesos y ofrece datos relevantes para el aprendizaje y las funciones que le apoyan. Al concluir que las estrategias neuroeducativas, favorecen los procesos educativos, tendríamos que hacer una segunda investigación, sobre cuáles son específicamente aquellas estrategias, que favorecen la actitud de los estudiantes y desarrollan sus habilidades metacognitivas.
Perspectivas del valor económico en la autenticidad de la Cerámica Chorotega
Authors: Calderón-Castro Jenny Andrea , Garro-Mena Leonardo
Published: January 2024

La Cerámica Chorotega, protegida como patrimonio cultural inmaterial y bajo una denominación de origen (DO), se enfrenta al desafío de su comercialización en el mercado. Este artículo aborda el análisis de las autenticidades presentes en este contexto, buscando establecer una metodología de gestión de la autenticidad orientada hacia la acción del Consejo Regulador. Se examina cómo la DO, centrada en una autenticidad esencialista, puede limitar la comprensión de otras autenticidades presentes en la práctica cultural de la cerámica, sin considerar plenamente la dinámica y la evolución de la producción artesanal. A lo largo del texto, se plantea una perspectiva que evalúa variables clave para definir estrategias de acción que permitan conciliar la promoción mercantil con el respeto a las diversas facetas de autenticidad presentes en la producción cerámica. Esta propuesta metodológica busca balancear las necesidades del mercado con el mantenimiento de la riqueza cultural inherente a la tradición ceramista.
Bonsái de Alejandro Zambra: una narrativa elíptica y autoficcional
Authors: Jiménez Picado Dahiana
Published: January 2024

El carácter metaficcional de la novela Bonsái (2006) del escritor chileno Alejandro Zambra ha sido ampliamente comentado por la crítica literaria; no así su autoficcionalidad. A través del estudio de la figura del narrador, los tipos de omisiones presentes en el texto y diversos elementos extraliterarios que conforman la poética del autor, este artículo comprueba cómo la narrativa elíptica y autoficcional de la novela representa un abandono de la tradición literaria realista y problematiza sobre las relaciones entre ficción y realidad. Ambos mecanismos narrativos de la obra —elisión y autoficción— le manifiestan constantemente al lector que se encuentra frente al producto de un proceso de escritura abierto, en el que participan tanto las (in)decisiones de su narrador como las interpretaciones de los lectores que completan los vacíos del texto.
Variación lingüística y características del francés de referencia a partir del análisis de un corpus de manuales costarricenses
Authors: Arias Corrales Ileana
Published: January 2024

En este estudio, de tipo documental y descriptivo de corte sociolingüístico, se analiza la presencia de la variación diatópica, diastrática, diafásica y adquisicional en un corpus de 23 manuales de francés publicados entre 2006 y 2018, dirigidos a aprendices del III ciclo de la educación general básica, elaborados y publicados en Costa Rica. El objetivo de este estudio fue determinar si la variación estaba presente en el corpus de manuales. Como resultado de este análisis, se describe una serie de características del francés de referencia, dentro de las que se encuentran un modelo de lengua con una gramática homogénea, basado en lo escrito, en el que prevalece la enseñanza de contenidos gramaticales y léxicos y en el que la cultura francesa es un importante referente. Se concluye que la variación diafásica es la que está más presente en el corpus de manuales de manera explícita. Las características del francés de referencia presentadas pueden constituir una base para futuras discusiones sobre los modelos de enseñanza de esta lengua en Costa Rica.
Psychosocial problems of healthcare for pregnant refugees – a systematic review
Authors: Klas Jakub , Grzywacz Aleksandra , Korga Mateusz , Kluz Natalia , Kulszo Katarzyna , Samardakiewicz Marzena
Published: January 2024

Introduction: As a result of increased refugee movements over the past few years, it is important to seek systemic solutions to provide medical care to those fleeing to safe countries as soon as possible, especially to pregnant women. To this end, it is necessary to know the existing problems and challenges associated with the care of pregnant refugees, and to find solutions to address them. Methods: A systematic review of the literature from 2016–2023 was conducted according to the PRISMA criteria. Results: Refugee women face a range of problems that need attention, ranging from changes in family dynamics, getting used to a new environment, fear for safety, lack of necessary support, isolation from family members, to overcoming the traumatic experiences left behind in the country of origin. Despite the adoption of assistance strategies in countries hosting refugee women, their implementation has often been far from ideal, even in highly developed countries, which has further negatively affected the mental state of pregnant refugee women in highly stressful situations. Conclusions: Caring for pregnant refugee women goes far beyond maternity care. It is an active process in which the main goals include giving birth to healthy offspring, achieving mental health, stress relief, and social integration of the refugee women themselves, including family relationships. We hope that the lessons learned from the mistakes of previous experiences will help the refugee host countries prepare for situations in which they need to assist pregnant women in crisis, including the provision of psychological support.
Cognitive functioning of a patient with herpes simplex virus encephalitis – a case study. An exemplary paper for the State Examination in the field of clinical psychology – neuropsychology
Authors: Zielińska Dorota Anita
Published: January 2024

This paper is an example of a case report for a state examination in the field of clinical psychology – neuropsychology. The case report was used during the examination in 2023 and received a positive rating. Its publication is an attempt to respond to the still reported difficulties in accessing exemplary works of this type. Due to publication limitations, some elements of the description have been shortened. The article can also be treated as a case study on the cognitive functioning of a person with active herpes encephalitis. Both screening scales, such as Addenbrooke’s Cognitive Examination III and Frenchay Aphasia Screening Test, as well as other scales to measure individual cognitive functions were used in order to assess the patient.
No effect of anodal F3/cathodal Cpz tDCS in a patient with severe treatment-refractory coenaesthetic hallucinations
Authors: Walczak Katarzyna Sylwia , Wysokiński Adam
Published: January 2024

This article presents a case report of a 57-year-old patient with chronic (>20 years) schizophrenia and severe treatment-refractory coenaesthetic hallucinations located within the genital area. Due to the lack of therapeutic alternatives, a course of transcranial direct current stimulation targeting the somatosensory cortex that represents the genital area was performed. The severity of symptoms was assessed using the Clinical Global Impression (CGI, Severity and Improvement), Positive and Negative Syndrome Scale (PANSS) and three visual-analogue scales, separately for the three distinctive features of “general discomfort”, “ripping out”, and “pain”. After completing the three-week transcranial direct current stimulation course, there were no changes between the baseline and final clinical scores.
Parmalim and Contemporary Hegemony of the World Religion's Missionary Agenda in Aceh Singkil
Authors: Pohan Zulfikar Riza Hariz
Published: January 2024

As a local religion, Parmalim in Aceh Singkil Regency Aceh Province is currently experiencing marginalisation in the presence of world religions such as Islam, Catholicism, and Protestantism. Based on the perspective of Islamic puritanism and Christian missionaries, Parmalim is categorised as unreligious or heretical. This study aims to analyse the genealogies of distribution and changes in Parmalim as the religious identity that has spread in Aceh Singkil. This qualitative research obtains the data through observation, interview, and documentation for two months. This study found that a segment of the Singkel community adheres to Parmalim as their cultural identity. Religious leaders, such as clerics and priests, actively seek to convert Parmalim adherents to Islam or Christianity through da’wah and missionary agenda. The hegemony of both Islam and Christianity makes their right still restricted. Thus, this study suggested the stakeholders fulfill their rights in education and religious and cultural practices as their basic needs.
Mosque Management in Urban City: Bargaining between the Sacred and the Social Challenges
Authors: Safei Agus Ahmad , Armstrong Paul Salahuddin
Published: January 2024

A mosque serves as a pivotal element in the structure of a Muslim community.  The function of a mosque extends beyond its religious capacity as a place for worship, playing a vital role in addressing the social problems that the community faces. To explore this, the present study focuses on the strategy employed by Masjid Raya Bandung to manage and overcome various social problems around its vicinity. Utilising a descriptive-analytical approach, the present study aims to depict the existing social phenomena around Masjid Raya Bandung (The Grand Mosque of Bandung) in the Province of West Java, Indonesia, with specific research variables.  Non-documentary data is obtained through participant observation and in-depth interviews. Located in the city's heart, across the city hall, a place of public gathering, the Grand Mosque of Bandung operates within a business and materialistic environment. The faced challenges include sanitation issues, unregulated street vendors tied to an informal economy, prevalent crime, covert prostitution in the vicinity, and escalating consumerism from nearby shopping centres. The study underscores the mosque as not only a spiritual oasis but also a socio-religious institution actively participating in providing solutions for various social issues within its urban setting. It is confirmed that the mosque's function is not only for ritual things but also for social activities in urban Islamic societies, particularly in managing and overcoming various social problems that surround the mosque.
Subject and Scripture: Exploring Existential Moments in the Ordinary Reading of Scripture
Authors: Hambali R. Yuli Ahmad
Published: January 2024

Scripture reading is not only a means of extracting meaning from sacred texts, but also a way to attain certain spiritual experiences. In the Islamic tradition, reading the scriptural text, such as the holy Quran, can lead readers to certain spiritual experiences that may fundamentally alter their awareness and understanding of reality. These experiences are accessible not only to readers with certain modalities but also to ordinary readers. This study analyses how ordinary readers can experience these existential moments. Data was collected through a literature review and documentation of the experiences of ordinary readers who have had spiritual-existential moments while reading scripture (the holy Quran). Data was analysed using Heidegger’s phenomenological hermeneutics. The results of the study indicate that readers of scripture, such as the holy Quran, have the same potential to experience existential moments that can alter their awareness and perspective on the meaning of life. These existential moments are moments of revelation of the meaning and divine guidance within oneself, allowing the reader to gain spiritual experience. The nature of scripture and the role of God as the author who is continuously present throughout the reading process allows even ordinary readers to experience existential moments that can alter their awareness and their way of being in the world.
Numerical investigation of the stress-strain state of zirconium dioxide pin structures manufactured using CAD CAM technologies
Authors:   Institute of Mechanics, Moscow State Lomonosov University, Dzhalalova Margarita , Stepanov Aleksandr ,   Russian University of Peoples’s Friendship, Apresyan Samvel ,   Moscow State Evdokimov Medical Stomatologic University, Oganyan Alisa
Published: January 2024

Numerical studies were carried out to determine the stress-strain state of pin stump structures made of zirconium dioxide. The calculation models were part of the dentoalveolar segment in the form of a cylinder, composed of a single-rooted tooth, dentin, periodontal ligament, compact bone of the alveolus, gums, spongy bone and a monolithic structure consisting of a crown fixed on a stump insert and a rod-pin. Three cases of such pin design models were considered. A numerical study was carried out for three different thicknesses of the rod, which were modeled as follows: the volume of the 2nd and 3rd pins doubled compared to the previous one – case 1 (thin rod), case 2(medium) and case 3 (thick). The finite element method was used to study the field of displacements and stresses according to von Mises both in the structures themselves and in the tissues surrounding them. Two cases of the load on the chewing surface of the tooth crown were established for comparative analysis in all cases: a distributed vertical load of 100 N and the same load at an angle of 45°. As a result of numerical studies, pin structures case 2 and 3 showed an ad-vantage over the design with a thin rod (case 1) both in terms of displacements and stresses. Case2 (average rod thickness) is recommended for use in practice. Structures of this type can be used to restore the crown part of the tooth in case of its complete absence or significant destruction, as well as a support for a bridge prosthesis.
Using correspondence analysis and log-linear models to investigate the factors affecting cardiovascular disease
Authors:   University of Arizona, Sabir Qurat Ul An , Kuchumov Alex ,   Perm National Research Polytechnic University, Nguyen-Quang Tri ,   Dalhousie University
Published: January 2024

Cardiovascular disease is the main cause of mortality in the World. This issue has seriously alarmed governments of developed and developing countries both. Diseases related to the heart play a role as the highest risk for human health. There are many factors contributing to the development of these diseases including poor diet, sedentary lifestyle, high blood pressure and hypertension. In this paper, we present a study of the influence of different factors by the correspondence analysis and log-linear models to deal with prediction of cardiovascular disease development. A survey has been conducted amongst affected people of different age groups, gen-der, and various education levels. Based on this data, we could determine which group would beat the higher risk leading to the cardiovascular disease. It should be noted that all participants were suffering from cardiovascular disease either slightly or seriously. Our findings show that women are at higher risk than men being affected by cardiovascular disease. Moreover, different factors such as smoking, high cholesterol level, physical inactivity and poor diet contribute significantly to the possibility for this disease. Via our analyses, we also can obtain a better comprehension of the data structure and better interpretation of the results by combining two approach-es (correspondence analysis and log-linear models). Also, it is concluded that correspondence analysis allows us to find the strong correlations between involving variables. That could lead to the conception of prognostic and biomechanical models using the inter-correlations between variables and building a good structure of big data in the future.
Dynamic model of upper extremity and its application: a systematic review
Authors:   University of Tun Hussein Onn Malaysia, Saad Syazana , Ibrahim Norzuria , Osman Noor Azuan Abu
Published: January 2024

Dynamics models are widely used in analyzing kinematics and kinetics analysis. Dynamic modeling and simulation can be useful in estimating the torques/forces produced in the limb during various motions, as well as any potential dangers. The aim of this research is to examine the method that is preferable in analyzing the dynamic model of the upper extremity and its application. Several methods have been identified and widely used in analyzing the dynamic model of the upper extremity such as Kane’s method, Lagrange method, optimization method, regression method and many more. Kane's approach, on the other hand, is most commonly used to analyze3D arm segments due to its advantages which is a vector-based approach. The Lagrange approach is suitable to use when the potential and kinetic energy of a system could be easily identified. Meanwhile, most of the researchers used statistical analysis to verify their model and calculation. However, it could be difficult to replicate the simulation work of others because some were not publicly available. Thus, it was recommended to choose a reference from prior studies that will serve as guidance for researchers to solve relevant issues in this field.
Identification of pathobiomechanical markers of statokinesiograms on the example of neural network identification of a post-stroke state
Authors:   Mechanical Engineering Research Institute of the Russian Academy of Sciences (IMASH RAN), Stepanyan Ivan , Grokhovsky Sergey ,   Research Center "MERA", Savkin Mikhail ,   Peoples’ Friendship University of Russia (RUDN University)
Published: January 2024

The purpose of this study is neural network modeling and determination of the parameters of statokinesiograms, which are carriers of useful information about the features of postural regulation, which determined the obtained trajectory of movements of the human center of mass. A technique for obtaining informative markers by identifying clustering centroids based on self-organizing Kohonen neural networks with the Euclidean metric has been developed. Kohonen networks trained without a teacher (that is, without the use of a priori diagnostic information about the state of the subjects) are a powerful and informative method that allows you to obtain not only graphic, but also mathematical markers of health disorders in subjects, to explore the biomechanics of micromovements of the center of pressure based on a flexible mathematical apparatus – neural network cluster analysis. On the example of the identification of the post-stroke state, a neural network analysis of stabilometric data was carried out and a method for identifying pathobiomechanical markers of statokinesiograms was shown, which made it possible to standardize the type affiliation of the groups of subjects. With the help of neural networks, it was possible to identify clusters that are amenable to biomedical interpretation with a reliability of up to 95.9 %, which determines the theoretical significance of the results obtained. Decision trees and a supervised multilayer neural network were also considered. A multilayer neural net-work made it possible to identify markers of health disorders with a probability of 71.9 %.
Stara i nova terminologija u opisu tkanina splitske ženske nošnje
Authors: Ribarović Vana
Published: January 2024

Prilikom pregleda zapisa u muzejskoj dokumentaciji Etnografskog muzeja Split, prije provedbe konzervatorsko-restauratorskih radova na nekoliko predmeta koji su dijelovi svečane ženske splitske narodne nošnje, uočeno je da su pri inventarizaciji, kod opisa temeljne tkanine, korišteni termini lokalnog govora i tadašnjeg standardnog jezika koji su danas nejasni. Cilj rada je objasniti i prevesti termine zatečene u dokumentaciji referirajući se na stručnu terminologiju dostupnu na više svjetskih jezika u rječnicima međunarodne organizacije Centre International d’Etude des Textiles Anciens (CIETA), relevantnu stručnu literaturu na hrvatskom jeziku i rječnike hrvatskog jezika. Važnost dokumentacije i njezina neodvojivost od predmeta, osobito u muzejskom kontekstu, podrazumijeva da ona bude razumljiva i izvan muzejskog kruga.
Gospodarenje vodom i otpadom u srednjovjekovnom i novovjekovnom Gradecu
Authors: Sekulić Petar
Published: January 2024

S ciljem utvrđivanja slojeva povijesnog razvoja, Hrvatski restauratorski zavod proveo je 2021. godine multidisciplinarna konzervatorsko-restauratorska i arheološka istraživanja sjevernog dvorišta Banskih dvora. Rezultati su potvrdili kontinuitet naseljavanja zagrebačkoga gornjogradskog platoa od prapovijesti do danas, a poslužili su kao osnova za izradu projektno-tehničke dokumentacije potrebne za cjelovitu obnovu potresom iz 2020. godine oštećene zgrade Vlade RH. Tijekom arheoloških istraživanja sjevernog dvorišta pronađeni su brojni nalazi ostataka stambenih i gospodarskih objekata te gradske infrastrukture koji nam omogućavaju razumijevanje tehnološke strane povijesnog razvoja gospodarenja vodom i otpadom unutar gradskih zidina srednjovjekovnoga i novovjekovnog Gradeca.
Zlatne ornamentirane draperije kao vrelo novih saznanja o slikarstvu Nikole Božidarevića
Authors: Kolić Pustić Mara
Published: January 2024

U radu je prezentirano interdisciplinarno istraživanje zlatnih ornamentiranih draperija Nikole Božidarevića. Opisano je stanje očuvanosti i postupak uklanjanja materijala iz naknadnih intervencija na slici Navještenje. Proučeni su Božidarevićevi ornamenti i način njihova punciranja te su preliminarno istraženi u širem kontekstu djelovanja toga majstora. Usporedbom s tkanjem zlatno-svilenih baršuna talijanskog quattrocenta, utvrđene su poveznice s Božidarevićevom izvedbom zlatnih ornamentiranih draperija. Prezentiran je i hipotetski predložak ornamenta za koji je utvrđeno da je korišten za prikaz plašta Bogorodice na slici Navještenje. Detektirane su grupe draperija sa sličnim motivom ornamenta, među kojima je i jedna Hamzićeva, što nudi dodatnu dimenziju sagledavanja značenja ornamentiranih draperija.
Effects of Flavourzyme and Alkaline Protease Treatment on Structure and Allergenicity of Peanut Allergen Ara h 1
Authors: Shu Erlian , Wang Shuo , Kong Xiangxiang , Sun Xiaodong , Yang Qiaoling , Chen Qin , Niu Bing
Published: January 2024

Research background. Peanut allergy poses a significant threat to human health due
to the increased risk of long-term morbidity at low doses. Modifying protein structure to affect sensitization is a popular topic.
Experimental approach. In this study, the purified peanut allergen Ara h 1 was enzymatically hydrolysed using Flavourzyme, alkaline protease or a combination of both. The binding ability of Ara h 1 to antibodies, gene expression and secretion levels of the proinflammatory factors interleukin-5 and interleukin-6 in Caco-2 cells was measured. Changes in the secondary and tertiary structures before and after treatment with Ara h 1 were analysed by circular dichroism and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).
Results and conclusions. The results indicated a decrease of the allergenicity and proinflammatory ability of Ara h 1. The evaluation showed that the Flavourzyme and
alkaline protease treatments caused particle shortening and aggregation. The fluorescence emission peak increased by 3.4-fold after the combined treatment with both proteases. Additionally, the secondary structure underwent changes and the
hydrophobicity also increased 8.95-fold after the combined treatment.
Novelty and scientific contribution. These findings partially uncover the mechanism of peanut sensitization and provide an effective theoretical basis for the development of a new method of peanut desensitization.
Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells
Authors: Talapphet Natchanok , Kim Moon-Moo
Published: January 2024

Research background. Ageing is a biochemical, metabolic and genetic physiological phenomenon. The suppression of melanin biosynthesis, evident in the greying of the hair, is a hallmark of ageing resulting from translation failure, reduced enzyme activity and cellular senescence. Putrescine, the smallest member of the polyamine family and an organic chemical, is present in living mammalian cells and plays a crucial role in regulating skin melanogenesis. Therefore, the purpose of this study is to explore the effect of putrescine on the signalling pathways of melanogenesis in melanoma cells.
Experimental approach. Melanin production capacity of putrescine was analysed using a tyrosinase activity assay. To assess the cell viability of B16F1 cells exposed to putrescine, a tetrazolium dye MTT assay was performed. The effect of putrescine on melanin synthesis in the presence of H2O2 was evaluated using various in vitro assays in B16F1 cells. The effect of putrescine on melanin production in B16F1 cells was determined using a specific melanin production assay. Gene expression was analysed using real-time polymerase chain reaction (RT-PCR). Furthermore, the effect of putrescine on the expression of proteins related to melanin production in the cells treated with H2O2 was analysed by immunofluorescence and Western blot analysis.
Results and conclusions. Putrescine increased tyrosinase activity and showed no
cytotoxicity in B16F1 cells. In addition, putrescine effectively scavenged H2O2, as shown by the reduction of intracellular H2O2 amounts in 2’,7’-dichlorofluorescin diacetate analysis, and promoted melanin production in living cells. The stimulation of melanogenesis by putrescine was attributed to the increased expression of Mitf, Tyr, Trp-1 and Trp-2 genes. Immunofluorescence assays revealed that putrescine enhanced the expression of proteins associated with melanogenesis and upregulated TYR, TRP-1 and TRP-2 via the microphthalmia-associated transcription factor (MITF) and increased the expression of methionine sulfoxide reductases A (MSRA) and B (MSRB) in the cells treated with H2O2, effectively promoting melanogenesis. These results suggest that putrescine can be used to stimulate melanin synthesis.
Novelty and scientific contribution. This is the first study to investigate the effect of putrescine on the signalling pathways of melanogenesis in B16F1 melanoma cells. The results confirm that putrescine can promote melanogenesis through the expression of TYR, TRP-1 and TRP-2 via the MITF in cells treated with H2O2. Putrescine can be used exclusively as a cosmetic product to prevent premature greying of hair.
Tiskarski znak (signet) digitalizirane građe u Nacionalnoj i sveučilišnoj knjižnici u Zagrebu
Authors: Krpan Smiljanec Marina
Published: January 2024

Printer’s mark (signet) is a trademark that the printer printed on books and with which it can be identified. As a typographic feature of a printer’s/individual title, it appears already in the very beginnings of printing. In addition to the role of an identifier, its function was also protection against forgeries, since the printing of books was an expensive and complex process, but also communicative as documents, information, visual representation or messages expressed through symbolic representation. Since the 16th century, when the title page took on its present-day features, typographical element is almost always found in the same place - centered in the middle of the page below the title and author’s name, and above the name of the printer, the place and year of printing, as well as the permission to print ( if it is stated), and the motifs that appear in artistic expression are diverse. The authors of the printer’s mark are mostly unknown, so it is assumed that they were mostly printers. After a historical review of the earliest appearance of printing marks in Croatia and Europe, and a presentation of some of the printing marks of the most important European printers, paper presents research on printer’s marks carried out on digitized Croatica (works by Croatian authors, works printed in Croatia, works that talk about Croatia and Croats) on a sample of 44 units of library materials stored in the fund of the National and University Library in Zagreb printed in Latin letters, from the 16th, 17th and 18th centuries. The aim of the paper is to draw attention to the printer’s mark as a rare or almost non-existent independent subject of research among Croatian scholars, due to its importance in the study of book history. The research brings the names of the printers of works by Croatian authors (Croatica), the systematization of printing marks grouped into 9 groups according to artistic motifs, as well as information on the existence of mottos. The idea of ambiguity of the name of a printing mark, which as such should be associated with a certain book in a situation where printers continuously use the same mark for all works, is also put forward, which indicates that the printing mark assumes the function of a logo.
Karijera, kuhinja, konferencija: žene u hrvatskom društvu šezdesetih
Authors: Feldman Andrea , Kardum Marijana
Published: January 2024

Based on an analysis of Communist Party (i.e., League of Communists of Croatia/Yugoslavia) documents, as well as the women’s, academic, student and youth press, this article explores the status of women in Croatian society during the 1960s. It opens perspectives for the study of “the role and status” of women in communism, with emphasis on the under-researched 1960s, in comparison to scholarship on the Antifascist Front of Women (Antifašistička fronta žena, AFŽ) of the 1940s and 1950s and the second wave of feminism (neo-feminism) of the 1970s and 1980s. The 1960s saw a marked rise in women’s education and employment, which was not accompanied by an increase in their “visibility” in society nor in their political representation (in the period after the abolition of the AFŽ in 1953). Similarly, there was no reformulation of the “women’s question” prior to emergence of the first feminist demands in the form of criticism of or dissent against the state in the 1970s. The first part of the paper defines the problem of the declarative “solution” of the women’s question with the introduction of legal gender equality. Alongside demands for reform, the 1960s witnessed evidence of political, societal and economic crisis during which women, regardless of their ever-growing level of education and qualifications, could not find an unobstructed path to leading positions. Subordinating the women’s question under the class question hindered genuine change in the social status of women, because the place of women in society was an indicator of the failure of the state monopoly over issues pertaining to women. The second part of the article analyzes women’s participation in the student movements of 1968 and 1971, but also their involvement in the emerging civic initiatives of the same period. Criticism of the invisibility of women as active participants in student, youth and academic endeavours correlates to examples of misogynist attitudes that permeated society during the 1960s.
Kako mjeriti „povezanost s prirodom“? Provjera valjanosti i pouzdanosti skale Povezanost s prirodom na uzorcima učenika, roditelja i učitelja
Authors: Anđić Dunja
Published: January 2024

Previous research has confirmed the importance of measuring the level of connectedness to nature and its relationship to the development of positive emotions, pro-environmental attitudes, and behaviors towards nature. Research also suggests that connectedness to nature declines in adolescence and that family, teachers, and educational practice may be important factors in promoting significant development of connectedness to nature in school children. This paper presents research whose first objective was to examine the measurement indicators of validity and reliability of Mayer and Frantz’s (2004) “Connectedness to Nature Scale” in samples of Croatian and Slovenian schoolchildren, parents, and teachers, as well as the “Attitudes Toward the Environment Scale” in samples of schoolchildren. The second objective of the research was to examine the relationship between the level of connectedness to nature of pupils, teachers, and parents, pupils’ attitudes towards the environment, and their socio-demographic variables. The research sample consisted of a total of 1345 participants, pupils (N=762), their parents (N=568), and teachers (N=115) in primary schools in Croatia and Slovenia. The measurement indicators were determined for both scales in all three participant samples. Bivariate correlation analysis, non-parametric tests to determine differences between groups of participants, and multiple regression analysis were performed. Both scales yielded satisfactory measures of content validity and reliability. High arithmetic estimates for the degree of connectedness to nature were determined for all three samples. The results of the regression analysis indicate that the level of connectedness to nature of parents and teachers, as well as pupils’ attitudes towards the environment, help to explain pupils’ connectedness to nature, but also that the level of connectedness to nature “decreases” in relation to male gender and classroom teaching. The results of this study confirm previous research and have important implications, not only as a stimulus for future research, but also for future educational efforts in schools.
Tin Ujević (1891–1955) und die Avantgarde
Authors: Protrka Štimec Martina
Published: January 2024

Tin Ujević, der wohl bedeutendste Dichter der klassischen Moderne in Kroatien, stand zu Lebzeiten und in der späteren Rezeption in einem spannungsvollen Verhältnis zur Avantgarde. Der poetologische Wandel und die Schwankungen beim Einsatz avantgardistischer Mittel führten i.d.R. zu dem Schluss, es ginge bei Ujević lediglich um Elemente, Phasen oder Teilaneignungen der Avantgarde. Betont wird im vorliegenden Beitrag hingegen der umfassende Charakter von Ujevićs Eingriff ins literarische Feld, sein revolutionärer Bruch im Verhältnis zu den Kategorien Mimesis, Subjektivität und Linearität – lesbar als implizite Antwort auf die theoretische Debatte über die Wiederholbarkeit der Avantgarde.
Análise multitemporal do uso e ocupação do solo e morfométrica da microbacia do Córrego do Aranha em Itapeva-SP
Authors: Siqueira Henrique de Carvalho , Lima César Gustavo da Rocha
Published: January 2024

Do início do século passado até os dias atuais o Brasil teve grande migração de pessoas da zona rural para a urbana. Isso resultou em muitos casos em um crescimento desordenado das cidades e ocupação de áreas potencialmente inundáveis, que com a impermeabilização do solo potencializou tais efeitos e, com a constante expansão de áreas urbanas, tende a aumentar ainda mais a ocorrência de eventos extremos. O objetivo do presente trabalho foi analisar a evolução do uso e ocupação do solo entre os anos de 1991 e 2020, além de estudar os parâmetros morfométricos da microbacia do Córrego do Aranha, no município de Itapeva-SP. Essas análises foram realizadas com auxílio de imagens de satélite LANDSAT5 e LANDSAT8, além do modelo digital de elevação SRTM, através do software SPRING 5.4.3. Os resultados indicaram um crescimento da zona urbana em cerca de 88% dentro da bacia ao longo do período de estudo, sendo grande parte dessa expansão em área onde já se observavam inundações, em parte canalizada do curso d’água. Por fim os resultados da análise morfométrica apontaram também médias a baixas tendências a inundações naturais.
Análise da morfologia urbana das áreas de ressaca (wetlands) de Macapá: o caso do bairro do Congós
Authors: Spíndola Raysa Oliveira , Drach Patricia R C
Published: January 2024

O estudo da forma urbana, nesta pesquisa, foi abordado com base nos conceitos de M. R. G. Conzen (1960) que fundamentaram os estudos da Escola Inglesa de Morfologia Urbana. A pesquisa tem como objetivo analisar a evolução urbana nas áreas de ressaca da cidade de Macapá, Amapá, com ênfase no Bairro do Congós, onde se encontra um complexo de duas áreas de ressaca: Ressaca Chico Dias e Ressaca do Beirol. Na análise do bairro do Congós e de suas respectivas áreas de ressaca: ressaca Chico Dias e ressaca Beirol, foram identificadas duas regiões morfológicas, cada uma delas com características específicas: uma em área não alagável com padrão de ocupação regular e outra nas áreas de ressaca com um padrão de ocupação de palafitas. A partir dos mapas elaborados é observada a expansão da forma urbana cartesiana com a expansão da cidade. Nas áreas de ressaca esse modelo torna-se mais orgânico apresentando desenho semelhante a espinhas de peixe ou mesmo plantas, como as samambaias.
Infraestrutura Verde no Planejamento Urbano e Regional: Um roteiro para o macrozoneamento
Authors: Colusso Izabele , Madalena Maurício de Andrade
Published: January 2024

É cada vez mais evidente, seja pela ocorrência de desastres ambientais ou por outros efeitos negativos decorrentes de desequilíbrios naturais, que as ações humanas não podem ser pensadas de modo isolado ao sistema previamente estabelecido e sobre o qual se insere: a natureza. O estilo de vida contemporâneo é, e será cada vez mais, urbano, motivo pelo qual quase a totalidade das atividades humanas está direta ou indiretamente relacionada à construção, expansão ou manutenção da vida na cidade. Nessa perspectiva, o objetivo da presente pesquisa foi verificar como as questões ambientais relacionadas à infraestrutura verde, na figura das zonas da Reserva da Biosfera da Mata Atlântica, podem ser utilizadas como embasamento para propostas de planejamento urbano e regional voltadas ao desenvolvimento sustentável, a fim de identificar e sugerir uma estratégia metodológica para o planejamento territorial. Para tanto, a partir do conceito de infraestrutura verde foi desenvolvida uma reflexão teórica sobre sua relação com as escalas do planejamento territorial e, posteriormente, sob essa ótica, foi abordado o caso prático do Planejamento Ambiental da Quarta Colônia, região que abrange nove municípios no Estado do Rio Grande do Sul. Foram utilizadas ferramentas com base na tecnologia da informação, recursos de computação gráfica, processamento digital de imagens, associação de banco de dados e informações geográficas. Como resultado foi identificado e proposto um modelo baseado no encadeamento de etapas de planejamento, desde o nível regional até o nível local, de modo a condicionar o planejamento urbano às estratégias de infraestrutura verde.
Systematization of Urban Instruments via SWOT Matrix Analysis: A Study of the Master Plans of Araraquara-SP, Brazil
Authors: Medeiros Sandra Batista , Gonçalves Luciana Márcia
Published: January 2024

This study aims to systematize and analyze the utilization of urban instruments stipulated by the City Statute in the first and second generations of the master plans for Araraquara, a city in São Paulo State, Brazil. We employed a modified SWOT analysis method to systematize information regarding exogenous conditions, which pertain to the regulation of instruments in accordance with federal legislations, and endogenous conditions, which relate to the instruments’ implementation by the municipal government. Our findings indicate that Araraquara has yet to fully leverage the potential of the urban instruments outlined by the City Statute, either in their definition or implementation. Moreover, the municipality has shown some maturity, drawing from the experiences of the first-generation master plan. From this vantage point, numerous tools have either not been implemented, inappropriately applied, or undergone decharacterization due to amendments from complementary laws, particularly after the plan’s revision in 2014.
Use of Recycled Acid for Kraft Lignin Production
Authors: Lima Erickson Alex de , Lima Rodrigo , Iarosz Kelly Cristiane , Souza Marco Antonio Cardoso de , Sandrino Bianca
Published: January 2024

The present study aimed to obtain and characterize Kraft lignin from black liquor from a cellulose industry. The black liquor was collected and subjected to physical-chemical analysis. Then, acid precipitation was carried out using recycled acid from car batteries (ARA) to obtain Kraft lignin. The characterization of lignin involved techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), dynamic light scattering ( DLS) and Zeta potential. Morphological analyzes revealed irregular structures, including plates and spherical structures. The XRD results allowed the identification of the phases present in the structure of the samples. DLS indicated variation in average sizes throughout the filtration and centrifugation process, attributed to clumping during phase separation. Zeta potential values were consistent with previous studies. The FTIR analysis highlighted characteristics of the chemical bonds of Kraft lignin, indicating the viability of the obtaining process, especially when using recycled acid, contributing to the removal of two environmentally harmful wastes: black liquor and battery acid. The lignin yield was as expected, with an average of 30.74 ± 0.0004% for PA sulfuric acid and 29.76 ± 0.0059% for recovered sulfuric acid. These results are in accordance with literature standards, especially considering the use of Eucalyptus grandis.
Post-pandemic appropriation in an urban park: notes from an analysis of the use of urban furniture in Parque da Gare, in Passo Fundo/RS
Authors: Cambrussi Laura Pasa , Cardoso Grace Tibério
Published: January 2024

The pandemic has established a contradiction in cities, where a public space, such as an urban park, which facilitates activities and social interactions, has also been the driving force behind the transmission of the COVID-19 virus. Thus, this new dynamic may have had an impact on the user’s view of the city and its attributes, forcing facets of aversion into urban respiration. In this way, the aim is to investigate the process of use and appropriation of Parque da Gare, in Passo Fundo, in the north of the state of Rio Grande do Sul, based on the behavior and perception of users of the space, after the pandemic scenario. The methodology was applied in two stages: firstly, to map the process of users’ choices, the behavioral analysis method was applied, carrying out systematic observations. In the second step, observations were combined with the user’s perception through online questionnaires, contributing to a macro assessment. Discussing the results, it was possible to see that significant changes in the appropriation of urban furniture occurred, along with impacts on preference. It was noted that survey respondents do not feel safe using local furniture, which requires interventions in terms of management, maintenance and new project proposals in parks. With the work, observed preferences were spatialized, understanding patterns of attitudes and behaviors, contributing to the understanding of urban perceptions. It is concluded that these places of immense value in the city’s health require adjustments, to reconnect the user with the park’s infrastructure, guaranteeing more positive and safe sensations in this return to the city.