bluuebunny/crossref_metadata_2025 huggingface dataset:
Zukunft auf Leinwand. Methoden der Visualisierung und ihre Funktionen für Organisationen
Authors: Wendt Thomas , Freis Tamara , Schröer Andreas , Schütz Friederike
Published: February 2024

Der Beitrag der Zeitschrift „Gruppe. Interaktion. Organisation (GIO)“ analysiert die Funktion von Visualisierungen als methodisches Gestaltungsprinzip der Zusammenarbeit in Organisationen. Visualisierungen werden gegenwärtig eingesetzt, um ko-kreative Prozesse zu unterstützen und zu systematisieren. So soll im Design Thinking die Arbeit an und vor Leinwänden die Internalisierung organisationaler Umwelten ermöglichen, realisiert sie im Business Modelling anspruchsweise die Demokratisierung von Unternehmertum oder soll sie in der Anwendung des Operating System Canvas die ko-kreative Aushandlung von Leitlinien der Zusammenarbeit unterstützen. Durch dieses Vorgehen wird ein erneuter Visual Turn der Managementlehre und damit eine Verschiebung beim Einsatz von Visualisierungen sichtbar: Mithilfe einer theoriesystematischen Analyse zeigt der Beitrag, dass sich die Verwendung von Visualisierungen von einem steuerungsaffinen Modus struktureller Handlungsvorgaben zu einem methodischen Prinzip wandelt, das ko-kreative, ergebnisoffene Aushandlungsprozesse zum Mittel der organisationalen Zukunft macht. Organisationsprozesse sollen auf Leinwänden sichtbar und dadurch als Gegenstand gemeinsamer Aushandlung verfüg- und veränderbar werden.
The endoplasmic reticulum stress-related genes and molecular typing predicts prognosis and reveals characterization of tumor immune microenvironment in lung squamous cell carcinoma
Authors: Wang Ruolan , Huang Yanhua , He Juan , Jin Shan , Li Xin , Tan Kun , Xia Wei
Published: February 2024

Background

Endoplasmic reticulum stress (ERS) acts critical roles on cell growth, proliferation, and metastasis in various cancers. However, the relationship between ERs and lung squamous cell carcinoma (LUSC) prognoses still remains unclear.

Methods

The consensus clustering analysis of ERS-related genes and the differential expression analysis between clusters were investigated in LUSC based on TCGA database. Furthermore, ERS-related prognostic risk models were constructed by LASSO regression and Cox regression analyses. Then, the predictive effect of the risk model was evaluated by Kaplan–Meier, Cox regression, and ROC Curve analyses, as well as validated in the GEO cohort. According to the optimal threshold, patients with LUSC were divided into high- and low- risk groups, and somatic mutations, immune cell infiltration, chemotherapy response and immunotherapy effect were systematically analyzed.

Results

Two ERS-related clusters were identified in patients with LUSC that had distinct patterns of immune cell infiltration. A 5-genes ERS-related prognostic risk model and nomogram were constructed and validated. Kaplan–Meier curves and Cox regression analysis showed that ERS risk score was an independent prognostic factor (p < 0.001, HR = 1.317, 95% CI = 1.159–1.496). Patients with low-risk scores presented significantly lower TIDE scores and significantly lower IC50 values for common chemotherapy drugs such as cisplatin and gemcitabine.

Conclusion

ERS-related risk signature has certain prognostic value and may be a potential therapeutic target and prognostic biomarker for LUSC patients.
Shoreline subsurface dams to protect coastal aquifers from sea level rise and saltwater intrusion
Authors: Abd-Elaty Ismail , Kuriqi Alban , Pugliese Lorenzo , Ahmed Ashraf
Published: February 2024

Fresh groundwater in arid and highly populated regions is limited. In coastal aquifers, the deterioration of fresh groundwater is accelerated by saltwater intrusion, primarily occurring through lateral encroachment and vertical movements in the proximity of discharging wells. Coastal regions have high salinity due to saline intrusion, where many abstraction wells are turned off by this high salinity, which leads to increased freshwater supply costs. This study investigates the performance of new approach using the shoreline subsurface dams (SSDs) for mitigating the saline water wedge in coastal aquifers, where the dams are installed at the shoreline (distance from shoreline = 0). Specifically, the current study's novelty is testing the effectiveness of SSDs by different relative heights ranging from 0.05 to 0.50 in the test case (Henry problem) and from 0.09 to 0.53 relative to the aquifer thickness in the field scale aquifer (Biscayne aquifer, Florida, USA). The results showed an exponential increase in salt repulsion for increasing SSDs height, reaching a maximum of + 0.70%, + 1.80%, + 3.25%, + 5.80%, + 10.45%, and + 18.40% for the dam height to aquifer thickness ratios of 0.09, 0.18, 0.26, 0.35, 0.44 and 0.53, respectively, in the field scale case. The SSDs increase the freshwater storage at the coastal zones where the low salinity occurs and reduces the freshwater supply cost. Despite the positive impact of height on repulsion, important factors such as economics, construction aspects, geographical suitability, and environmental impacts must be considered for real applications. This is crucial to develop feasible solutions applicable globally under the growing pressure of sea level rise.
Biosafety evaluation of etoposide lipid nanomedicines in C. elegans
Authors: Moukhtari Souhaila H. El , Muñoz-Juan Amanda , Del Campo-Montoya Rubén , Laromaine Anna , Blanco-Prieto María J.
Published: February 2024

Neuroblastoma is a pediatric tumor that originates during embryonic development and progresses into aggressive tumors, primarily affecting children under two years old. Many patients are diagnosed as high-risk and undergo chemotherapy, often leading to short- and long-term toxicities. Nanomedicine offers a promising solution to enhance drug efficacy and improve physical properties. In this study, lipid-based nanomedicines were developed with an average size of 140 nm, achieving a high encapsulation efficiency of over 90% for the anticancer drug etoposide. Then, cytotoxicity and apoptosis-inducing effects of these etoposide nanomedicines were assessed in vitro using human cell lines, both cancerous and non-cancerous. The results demonstrated that etoposide nanomedicines exhibited high toxicity and selectively induced apoptosis only in cancerous cells.

Next, the biosafety of these nanomedicines in C. elegans, a model organism, was evaluated by measuring survival, body size, and the effect on dividing cells. The findings showed that the nanomedicines had a safer profile than the free etoposide in this model. Notably, nanomedicines exerted etoposide’s antiproliferative effect only in highly proliferative germline cells. Therefore, the developed nanomedicines hold promise as safe drug delivery systems for etoposide, potentially leading to an improved therapeutic index for neuroblastoma treatment.

Graphical Abstract
Photoconductivity in self-assembled CuO thin films
Authors: Anand Akhil M. , Raj Aruna , Salam Jishad A. , Adithya Nath R. , Jayakrishnan R.
Published: February 2024

Self-assembly is the most promising low-cost and high-throughput methodology for nanofabrication. This paper reports the optimization of a self-assembly process at room temperature for the growth of copper oxide (CuO) based nanostructures over a copper substrate using aqueous potassium hydroxide (KOH) solution as the oxidizing agent. The monoclinic phase of CuO nanostructures grown over the copper substrate was confirmed from the X-ray diffraction (XRD) and micro-Raman analysis. The overall chemical composition of nanostructures was confirmed to be that of CuO from its oxidation state using X-ray photoelectron spectroscopy (XPS). Photodetectors were engineered with the structure Cu/CuO/Ag. The photodetectors exhibited a response to both ultraviolet and visible light illumination. The optimized Cu/CuO/Ag structure exhibits a responsivity of ~ 1.65 µA/W, with an ON:OFF ratio of ~ 69 under a bias voltage of 0.01 V. The temporal dependence of photo-response for the optimized photodetector displayed the persistent nature of photoconduction indicating a delay in charge carrier recombination which could potentially be exploited for photovoltaic applications.
The future of tire energy: a novel one-end cap structure for sustainable energy harvesting
Authors: Al-Najati Ibrahim Ali , Jasim Abbas F. , Chan Keng Wai , Pung Swee-Yong
Published: February 2024

Piezoelectric energy harvesting is gaining popularity as an eco-friendly solution to harvest energy from tire deformation for tire condition monitoring systems in vehicles. Traditional piezoelectric harvesters, such as cymbal and bridge structures, cannot be used inside tires due to their design limitations. The wider adoption of renewable energy sources into the energy system is increasing rapidly, reflecting a global attraction toward the utilization of sustainable power sources (Aljendy et al. in Int J Power Energy Convers 12(4): 314–337, 2021; Yesner et al. in Evaluation of a novel piezoelectric bridge transducer. In: 2017 Joint IEEE International Symposium on the Applications of Ferroelectric (ISAF)/International Workshop on Acoustic Transduction Materials and Devices (IWATMD)/Piezoresponse Force Microscopy (PFM). IEEE, 2017). The growing interest in capturing energy from tire deformation for Tire Pressure Monitoring Systems (TPMS) aligns with this trend, providing a promising and self-sustaining alternative to traditional battery-powered systems. This study presents a novel one-end cap tire strain piezoelectric energy harvester (TSPEH) that can be used efficiently and reliably inside a tire. The interaction between the tire and energy harvester was analyzed using a decoupled modeling approach, which showed that stress concentration occurred along the edge of the end cap. The TSPEH generated a maximum voltage of 768 V under 2 MPa of load, resulting in an energy output of 32.645 J/rev under 1 MPa. The computational findings of this study were consistent with previous experimental investigations, confirming the reliability of the numerical simulations. The results suggest that the one-end cap structure can be an effective energy harvester inside vehicle tires, providing a valuable solution for utilizing one-end cap structures in high-deformation environments such as vehicle tires.
Should there be a paradigm shift for the evaluation of isthmic thyroid nodules?
Authors: Babayid Yağmur , Gökçay Canpolat Asena , Elhan Atilla Halil , Ceyhan Koray , Çorapçıoğlu Demet , Şahin Mustafa
Published: February 2024

Purpose

Although the thyroid isthmus seems like a rudimentary structure that connects bilateral lobes, it is an undiscovered area that needs to be explored. Currently, the data is evolving that the increase in the risk of malignancy is higher in the isthmic nodules, and extrathyroidal extensions and lymph node metastases are more common in isthmic-derived malignant thyroid nodules. Therefore, we aimed to compare the malignancy rate of isthmic and lobar nodules, the ultrasonographic features of isthmic and lobar nodules, and presence of lymph node metastases, distant metastases, and extrathyroidal invasions in malignant isthmic nodules.

Methods

In this retrospective study, we enrolled patients between the ages of 18–80 years, who had thyroid nodule/nodules cytology and/or pathology results from January 2009 to November 2022. 9504 nodules were selected for the analysis of US findings, cytopathology results, and malignancy rates.

Results

A mean ± SD age of 55.3 ± 13.0 years with a female to male ratio of [7618 (80.2%)/1886(19.8%)] were included in the study. 962 of the nodules were at isthmic localization; whereas 8542 nodules were at lobar localization. 1188 nodules were resulted as malignant from histopathological evaluation. Of the 1188 malignant nodules, 986 nodules were (83.0%) PTC, 114 nodules (9.6%) were FTC, 55 nodules were (4.6%) MTC, 16 nodules 1.3% were Hurtle cell carcinoma, 8 nodules (0.7%) were anaplastic thyroid carcinoma, and 9 nodules (0.8%) were thyroid tumors of uncertain malignant potential (TT-UMP). 156 of the malignant nodules (13.1%) were located in the isthmus, whereas the majority of the malignant nodules (n = 1032, 86.9%) were located at the lobar parts (right or left) of the thyroid. When the metastasis patterns of isthmic and lobar thyroid cancers were examined, no significant relationship was found between isthmic and lobar cancers in terms of capsule invasion (p = 0.435), muscle invasion (p = 0.294), and lymph node metastasis (p = 0.633). A significant relation was found between nodule localization (isthmus-upper-middle and lower lobes) and malignancy (p < 0.001). In our logistic regression analysis, isthmic and upper pole nodule localizations, age and TI-RADS were evaluated as independent risk factors for malignancy (p < 0.001 for all factors).

Conclusion

We recommend nodule localization has to be considered an additional risk factor when performing a Fine Needle Aspiration Biopsy for the increased malignancy risk in this localization.
Ecological transition in a monetary economy of production: a heterodox approach
Authors: Solari Maurizio , Le Bloc’h Alexandre , Rossi Sergio
Published: February 2024

The global warming challenge is probably the major issue of our epoch, calling for a concerted response involving as many entities as possible. The economic system being the main responsible of this troubling situation, it is logical to address it first. The actual monetary economy of production has the banking system as the main driver of its functioning which justifies putting our attention on it. Central banks play a prominent role in such a system. They thus dispose of a relevant room for maneuver, which constitutes one of the main topics addressed here. Before that, this article discusses environmental concerns in a monetary production economy, advocating for an ecological economics approach as our privileged analytical foundation and highlighting the seminal role of the banking system in the monetary essence of our economic system, thus calling for an effort to enrich current monetary policy practices which must depart from the myth of ‘market neutrality’. We therefore propose four axes of intervention with regard to the greening of central banks’ action, which aim at redirecting credit away from carbon-intensive activities and towards low-carbon economic sectors. As needed as it is, adjusting monetary policy would however not suffice, the actual climate crisis being enrooted within the economic growth mantra applied through a profit-seeking scheme. A questioning of the very basis of our economic system is thus required to make the economy sustainable and finally safeguarding the conditions of life on earth.
Effects of local thermal non-equilibrium on hydraulic stimulation efficiency of enhanced geothermal systems
Authors: Fan Zhiqiang , Zhao Jiamin , Wang Dayong , Yue Feng , Wu Ziyan , Xue Ronggang
Published: February 2024

Motivated by hydraulic stimulation of enhanced geothermal systems, the present paper investigates the coupled thermo-hydro-mechanical response of a geothermal well imbedded in a thermoporoelastic medium, subjected to a non-isothermal fluid flux and convective cooling on the borehole surface. Our focus centers on the effect of local thermal non-equilibrium (LTNE) on the temporal-spatial evolution of temperatures, pore pressure, and stresses, where the solid and fluid phases have two distinct temperatures and local heat transfer between the two phases is addressed. We employ integral transform and load decomposition techniques to derive analytical solutions in the Laplace domain. This methodology allows us to disentangle and separate the individual contributions to changes in pore pressure and stresses from fluid injection and convective heat transfer. The results reveal that compared to the classical local thermal equilibrium model, the thermally induced pore pressure is slightly lower under LTNE conditions. The LTNE has a significant influence on the temporal evolution of thermally induced stresses, especially in the vicinity of the wellbore.
Mitigating alcohol-induced neurohepatotoxicity in male albino rats with avocado and mustard
Authors: AL-Qahtani Aishah Abdullah , Shati Ali Abdullah , Al-Doaiss Amin A. , Elsaid Fahmy Gad
Published: February 2024

Alcohol abuse is dangerous to one’s health and contributes to disorders such as neurotoxicity and hepatotoxicity worldwide. Twenty-five male albino rats, each weighing 200 ± 10 g, were divided into five groups. For 4 weeks, rats in the control group were given only a regular chow diet and ad libitum. Rats in the alcohol group received an oral gavage of alcohol at a dose of 40 mg/kg body weight each day. Rats in the alcohol and avocado extract group received oral gavage doses of 250 mg/kg b. wt./day of avocado extract and 40 mg/kg b. wt. of alcohol. Rats in the alcohol and mustard seed extract group received oral gavage doses of 250 mg/kg/day of mustard seed extract and 40 mg/kg/day of alcohol, respectively. Rats were given alcohol and a mixture of avocado and mustard seed extract at a dose of 250 mg/kg body weight each day by oral gavage for 4 weeks. Our results showed increased levels of hydrogen peroxide (H2O2) and lipid peroxidation in the liver and brain tissues, decreased glutathione content, glutathione peroxidase, superoxide dismutase, catalase, and glutathione-S-transferase. In rats consumed excessive alcohol, there was an increase in the activity of the tumor marker α-l-fucosidase in sera. Additionally, the liver and brain tissues of the alcoholic group showed decreased cytochrome c oxidase activity. Furthermore, changes in the expression levels of the genes for brain α-secretase and liver alcohol dehydrogenase (ADH) were observed. The administration of extracts from avocado and mustard seeds improved the state of oxidative stress and restored antioxidant enzyme activity. The expression levels of brain α-secretase and liver ADH genes were almost fully recovered at the molecular level.
Improving shelter conditions by implementing sustainable housing policies
Authors: Ismail Issam Hasan , Al-Hazmi Ahmed Mohammed Ahmed , Al-Hussein Abdul Razzaq
Published: February 2024

With increasing global awareness of the application of sustainability and its importance in preserving resources and the ability of future generations to access them, implementing sustainability has become a necessary issue. The housing sector is considered one of the largest energy consumers. Multiple reasons, such as displacement, forced deportation, and a continuation of the conflict, increased the need for housing to shelter the needy. Non-governmental organizations played an important role in helping the needy by establishing housing projects to shelter them. These projects are considered unsustainable for many reasons, such as assault on agricultural land, cutting down trees, not treating wastewater, the absence of sustainable housing principles, etc. This paper aims to address the problem by finding basic points that contribute to developing a sustainable housing policy that can be applied to future shelter projects. To reach the goal of the research, quantitative data was used to find out the opinions of housing and shelter specialists through a questionnaire that was designed according to data summarized from previous studies and formulated according to the five axes of the questionnaire. The questionnaire was then presented to 100 participants, after which the data was analyzed according to the application of the Social Statistical Package (SPSS) and the results were discussed. Providing recommendations for the importance of sustainable housing policies to achieve sustainable shelter, the establishment of a higher council for housing, updating laws, securing appropriate land, encouraging scientific research, and abolishing taxes.
A self-assembling split Nano luciferase-based assay for investigating Pseudomonas syringae effector secretion
Authors: Miao Pei , Zhou Jian-Min , Wang Wei
Published: February 2024

Many Gram-negative pathogens employ the type III secretion system (T3SS) to deliver effector proteins into host cells, thereby modulating host cellular processes and suppressing host immunity to facilitate pathogenesis and colonization. In this study, we developed a straightforward, rapid, and quantitative method for detecting T3SS-mediated translocation of Pseudomonas syringae effectors using a self-assembling split Nano luciferase (Nluc)-based reporter system. It was demonstrated that this system can detect effector secretion in vitro with an exceptionally high signal-to-noise ratio and sensitivity, attributed to the strong affinity between the split domains of Nluc and the intense luminescence generated by functional Nluc. During natural infections, effectors fused to a small C-terminal fragment of Nluc were successfully translocated into plant cells and retained their virulence functions. Furthermore, upon infection of plants expressing the N-terminal fragment of Nluc with these P. syringae strains, functional Nluc proteins were spontaneously assembled and produced bright luminescence, demonstrating that this system enables the straightforward and rapid assessment of P. syringae T3SS-mediated effector translocation during natural infections. In conclusion, the self-assembling split Nluc-based reporting system developed in this study is suitable for efficient in vitro and in planta detection of effectors secreted via T3SS.
Synergistic interactions of assorted ameliorating agents to enhance the potential of heavy metal phytoremediation
Authors: Sanjana S. , Jazeel K. , Janeeshma E. , Nair Sarath G. , Shackira A. M.
Published: February 2024

Pollution by toxic heavy metals creates a significant impact on the biotic community of the ecosystem. Nowadays, a solution to this problem is an eco-friendly approach like phytoremediation, in which plants are used to ameliorate heavy metals. In addition, various amendments are used to enhance the potential of heavy metal phytoremediation. Symbiotic microorganisms such as phosphate-solubilizing bacteria (PSB), endophytes, mycorrhiza and plant growth-promoting rhizobacteria (PGPR) play a significant role in the improvement of heavy metal phytoremediation potential along with promoting the growth of plants that are grown in contaminated environments. Various chemical chelators (Indole 3-acetic acid, ethylene diamine tetra acetic acid, ethylene glycol tetra acetic acid, ethylenediamine-N, N-disuccinic acid and nitrilotri-acetic acid) and their combined action with other agents also contribute to heavy metal phytoremediation enhancement. With modern techniques, transgenic plants and microorganisms are developed to open up an alternative strategy for phytoremediation. Genomics, proteomics, transcriptomics and metabolomics are widely used novel approaches to develop competent phytoremediators. This review accounts for the synergistic interactions of the ameliorating agent’s role in enhancing heavy metal phytoremediation, intending to highlight the importance of these various approaches in reducing heavy metal pollution.
The Church of St. Polyeuktos at Constantinople
Authors: Stroth Fabian
Published: February 2024

The Church of St. Polyeuktos is one of the most magnificent, but also most peculiar architectural achievements in Byzantine Constantinople. The accidental rediscovery of the building during construction work in Istanbul in the 1960s is legendary and considered one of the most sensational finds in Byzantine archaeology. Built by the aristocrat Lady Anicia Juliana, the reconstruction of the structure and the interpretation of its strange forms continue to challenge scholars today. The building gave rise to a whole series of archaeo-historical narratives, in which the City's byzantine protagonists and major monuments were woven into a coherent plot. This Element on the archaeology of St. Polyeuktos takes a closer look at these narratives and subject them to critical examination. In the end, the study of St. Polyeuktos will tell us as much about Byzantine architectural history in the second half of the twentieth century as about early Byzantine architecture itself.
From Randomness and Entropy to the Arrow of Time
Authors: Zuchowski Lena
Published: February 2024

The Element reconstructs, analyses and compares different derivational routes to a grounding of the Arrow of Time in entropy. It also evaluates the link between entropy and visible disorder, and the related claim of an alignment of the Arrow of Time with a development from order to visible disorder. The Element identifies three different entropy-groundings for the Arrow of Time: (i) the Empirical Arrow of Time, (ii) the Universal Statistical Arrow of Time, and (iii) the Local Statistical Arrow of Time. The Element will also demonstrate that it is unlikely that high entropy states will always coincide with visible disorder. Therefore, it will dispute that there is a strong link between the Arrow of Time and visible disorder.
THE UNIVERSAL THEORY OF THE HYPERFINITE II
$_1$
FACTOR IS NOT COMPUTABLE
Authors: GOLDBRING ISAAC , HART BRADD
Published: February 2024

We show that the universal theory of the hyperfinite II
$_1$
factor is not computable. The proof uses the recent result that MIP*=RE. Combined with an earlier observation of the authors, this yields a proof that the Connes Embedding Problem has a negative solution that avoids the equivalences with Kirchberg’s QWEP Conjecture and Tsirelson’s Problem.
“Making the Peaks Higher”: Foundations of Stanford University’s Growth, 1910–1960
Authors: Adams Stephen B.
Published: February 2024

This article breaks new ground in its portrayal of the process through which a private research university obtained foundation funding. Stanford University’s growth spurts after World War I and World War II were significantly enabled by financial support from the foundations of Carnegie, Rockefeller, and Ford. The process leading to Stanford’s receiving major grants primarily involved interactions among a small group of individuals and reflected the confidence of foundation presidents and other top administrators in the capacity of the university’s presidents and other leaders. The significance of such high-level interaction persisted even while major foundations professionalized, shifting responsibilities from trustees to staff. In the rendezvous between Stanford University and philanthropic foundations, these relationships mattered so much that at crucial junctures, funding to the university preceded expertise in the relevant field of study.
Indian adolescents’ perceptions of anaemia and its preventive measures: A qualitative study
Authors: Rathi Neha , Kansal Sangeeta , Raj Aryan , Pedapanga Nikitha , Joshua Immanuel , Worsley Anthony
Published: February 2024

High prevalence of anaemia is a severe public health problem in several low- and middle-income countries like India. A qualitative inquiry was designed to understand the perceptions of adolescents regarding anaemia and anaemia prevention measures. Convenience sampling was employed to recruit 39 adolescents (19 girls; 20 boys) from Tikari, India. Interviews were carried out in the local language, audio-recorded and transcribed verbatim. Hemoglobin concentration was also assessed from a single drop of capillary blood using the HemoCue, and the participants were asked to share their Science/Biology and Home Science textbooks. Interview data was analysed thematically. Descriptive statistics were used to examine the distributions of the hemoglobin data while textbooks were analysed using content analysis to verify the coverage of anaemia and anaemia-related matter. Seven themes were identified: (i) Poor understanding of the term anaemia; (ii) Minimal discussion about anaemia in classroom; (iii) Limited knowledge about symptoms of anaemia; (iv) Limited awareness about prevention and cure of anaemia; (v) Perception of iron folic acid and deworming tablets among students; (vi) Lack of contribution of health workers in the prevention of anaemia; (vii) No knowledge of ‘Anemia free India’ programme. More than half of the sample had anaemia (16.7% mild anaemia, 33.3% moderate anaemia, 2.8% severe anaemia). Content analysis revealed that there was limited discussion about anaemia in both Home Science and Science textbooks. Behavioural interventions should focus on inculcating healthy culinary and dietary practices and addressing the gaps in knowledge and understanding of anaemia and its prevention among adolescents.
Discursive scaling of solidarity through difference: Experiences of African women in the African diaspora
Authors: Wawire Gorrety Nafula
Published: February 2024

Drawing on data generated from a two-year ethnographic observation with a group of multiethnic Black women, this investigation delves into the ways they employ discursive and linguistic strategies, namely solidarity through difference and distinction, solidarity through denaturalizing difference, and solidarity through shared struggles and learning in deictically anchored interactions. The study presents a moment-by-moment analysis of culturally and socially situated conversations. These conversations allow us to see how the social actors enact different stance-taking and scaling practices to construct meanings about race that intersect with gender/transnational identities. Discursive practices show that when we closely attend to race, transnationalism, and gender, specifically considering the particularity of Black womanhood, new and more complex ways of understanding transnational identity formation emerge. Participants’ constructions indicate that women co-construct a unique brand of Black feminist solidarity that is not based on similarity but meaningfully created through differentiation and distinction. (Black immigrant women, solidarity, stance-taking, scaling and deixis difference, African diaspora, intersectionality)*
Exploring symptom clusters in mild cognitive impairment and dementia with the NIH Toolbox
Authors: Tyner Callie E. , Boulton Aaron J. , Slotkin Jerry , Cohen Matthew L. , Weintraub Sandra , Gershon Richard C. , Tulsky David S.
Published: February 2024

Objective:

Symptom clustering research provides a unique opportunity for understanding complex medical conditions. The objective of this study was to apply a variable-centered analytic approach to understand how symptoms may cluster together, within and across domains of functioning in mild cognitive impairment (MCI) and dementia, to better understand these conditions and potential etiological, prevention, and intervention considerations.

Method:

Cognitive, motor, sensory, emotional, and social measures from the NIH Toolbox were analyzed using exploratory factor analysis (EFA) from a dataset of 165 individuals with a research diagnosis of either amnestic MCI or dementia of the Alzheimer’s type.

Results:

The six-factor EFA solution described here primarily replicated the intended structure of the NIH Toolbox with a few deviations, notably sensory and motor scores loading onto factors with measures of cognition, emotional, and social health. These findings suggest the presence of cross-domain symptom clusters in these populations. In particular, negative affect, stress, loneliness, and pain formed one unique symptom cluster that bridged the NIH Toolbox domains of physical, social, and emotional health. Olfaction and dexterity formed a second unique cluster with measures of executive functioning, working memory, episodic memory, and processing speed. A third novel cluster was detected for mobility, strength, and vision, which was considered to reflect a physical functioning factor. Somewhat unexpectedly, the hearing test included did not load strongly onto any factor.

Conclusion:

This research presents a preliminary effort to detect symptom clusters in amnestic MCI and dementia using an existing dataset of outcome measures from the NIH Toolbox.
Wideband millimeter-wave reflectarray antenna with reduced cross-polarization
Authors: Sathyanarayanan Vidhyashree , Alsath Mohammed Gulam Nabi , Savarimuthu Kirubaveni , Kanagasabai Malathi
Published: February 2024

A novel wideband reflectarray antenna (RA) is designed for 5G millimeter (mm) wave communications in the frequency range of 26.5–36 GHz. The proposed unit cell is constructed using a grid periodicity of 0.52${{\lambda }_0}{ }$ that offers 636° phase change through phase delay lines (PDLs) (${{\theta }_{\text{s}}}$). These PDLs are attached to the outer end of the unit cell comprising semi-circular rings. Bandwidth enhancement is achieved by incorporating a corrugated slot technique and a suitable air gap beneath the substrate. The proposed center-fed reflectarray is composed of 513 elements distributed in a circular aperture (13.46${{\lambda }_0}$). Using mirror-symmetrical distribution of the unit cells, a cross-polarization reduction as low as −50 dB is realized. At 30 GHz, RA has a measured peak gain of 28.2 dBi, a sidelobe level of −14.3 dB, and an aperture efficiency of 31.4%. The prototype antenna is fabricated, and the simulation results are experimentally validated. The measured 1-dB and 3-dB gain bandwidths of the proposed reflectarray antenna are 31.3% and 41.6%, respectively. The proposed broadband reflectarray can be a potential choice for inter-satellite services like inter-satellite networking/satellite positioning and control; fixed satellite services such as GPS satellite synchronization and data direct to home TV; and satellite position fixing.
Seismic Anisotropy of Mafic Blueschists: EBSD‐Based Constraints From the Exhumed Rock Record
Authors: Ott Jason N. , Condit Cailey B. , Schulte‐Pelkum Vera , Bernard Rachel , Pec Matej
Published: February 2024

Seismic anisotropy constitutes a useful tool for imaging the structure along the plate interface in subduction zones, but the seismic properties of mafic blueschists, a common rock type in subduction zones, remain poorly constrained. We applied the technique of electron backscatter diffraction (EBSD) based petrofabric analysis to calculate the seismic anisotropies of 14 naturally deformed mafic blueschists at dry, ambient conditions. The ductilely deformed blueschists were collected from terranes with inferred peak P‐T conditions applicable to subducting slabs at or near the plate interface in active subduction zones. Epidote blueschists display the greatest P wave anisotropy range (AVp ∼7%–20%), while lawsonite blueschist AVp ranges from ∼2% to 10%. S wave anisotropies generate shear wave splitting delay times up to ∼0.1 s over a thickness of 5 km. AVp magnitude increases with glaucophane abundance (from areal EBSD measurements), decreases with increasing epidote or lawsonite abundance, and is enhanced by glaucophane crystallographic preferred orientation (CPO) strength. Two‐phase rock recipe models provide further evidence of the primary role of glaucophane, epidote, and lawsonite in generating blueschist seismic anisotropy. The symmetry of P wave velocity patterns reflects the deformation‐induced CPO type in glaucophane—an effect previously observed for hornblende on amphibolite P wave anisotropy. The distinctive seismic properties that distinguish blueschist from other subduction zone rock types and the strong correlation between anisotropy magnitude/symmetry and glaucophane CPO suggest that seismic anisotropy may be a useful tool in mapping the extent and deformation of blueschists along the interface, and the blueschist‐eclogite transition in active subduction zones.
Dynamical Importance of the Trade Wind Inversion in Suppressing the Southeast Pacific ITCZ
Authors: Gonzalez Alex O. , Ganguly Indrani , Osterloh Marissa , Cesana Gregory V. , DeMott Charlotte A.
Published: February 2024

Sea surface temperature (SST) gradients are a primary driver of low‐level wind convergence in the east Pacific Inter‐Tropical Convergence Zone (ITCZ) through their hydrostatic relationship to the surface pressure gradient force (PGF). However, the surface PGF may not always align with SST gradients due to variations in boundary layer temperature gradients with height, that is, the boundary layer contribution to the surface PGF. In this study, we investigate the observed northern hemisphere position of the east Pacific ITCZ using a slab boundary layer model (SBLM) driven by different approximations of the boundary layer virtual temperature field. SBLM simulations using the entire boundary layer virtual temperature profile produce a realistic northern hemisphere ITCZ. However, SST‐only simulations produce excessive equatorial divergence and southern hemisphere convergence, resulting in a latitudinally confined double ITCZ‐like structure. Observed virtual temperature gradients highlight the importance of northward temperature gradients strengthening with height from the equator to 15°S below the trade wind inversion (TWI). Our interpretation is that the equatorial cold tongue induces relatively weak high surface pressure and double ITCZ‐like convergence because the resulting layer of cold air is shallow. Concurrently, relatively strong high surface pressure spreads out in the southern hemisphere due to interactions between stratocumulus clouds and the ocean surface. Together, the equatorial cold tongue and the TWI/stratocumulus clouds enable a more northern hemisphere dominant ITCZ. Thus, we provide evidence of a dynamical link between the equatorial cold tongue, low clouds, and double ITCZs, which continue to be problematic in Earth system models.
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Authors: Loh Jian Sheng , Mak Wen Qi , Tan Li Kar Stella , Ng Chu Xin , Chan Hong Hao , Yeow Shiau Hueh , Foo Jhi Biau , Ong Yong Sze , How Chee Wun , Khaw Kooi Yeong
Published: February 2024

The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development, aging, and disease. The advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host interactions. Evidence has unveiled the bidirectional communication between the gut microbiome and the central nervous system, referred to as the “microbiota–gut–brain axis”. The microbiota–gut–brain axis represents an important regulator of glial functions, making it an actionable target to ameliorate the development and progression of neurodegenerative diseases. In this review, we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases. As the gut microbiome provides essential cues to microglia, astrocytes, and oligodendrocytes, we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative diseases. Subsequently, we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach, while also examining the role of gut microbiota-related neurotransmitters and gut hormones. Next, we examine the potential of targeting the intestinal barrier, blood–brain barrier, meninges, and peripheral immune system to counteract glial dysfunction in neurodegeneration. Finally, we conclude by assessing the pre-clinical and clinical evidence of probiotics, prebiotics, and fecal microbiota transplantation in neurodegenerative diseases. A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.
Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase
Authors: Takahashi Hideyuki , Bhagwagar Sanaea , Nies Sarah H. , Ye Hongping , Han Xianlin , Chiasseu Marius T. , Wang Guilin , Mackenzie Ian R. , Strittmatter Stephen M.
Published: February 2024

Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that reduction of progranulin (PGRN), a lysosomal protein associated with TDP-43 proteinopathy, also increases tau inclusions, causes concomitant accumulation of α-synuclein and worsens mortality and disinhibited behaviors in tauopathy mice. The increased inclusions paradoxically protect against spatial memory deficit and hippocampal neurodegeneration. PGRN reduction in male tauopathy attenuates activity of β-glucocerebrosidase (GCase), a protein previously associated with synucleinopathy, while increasing glucosylceramide (GlcCer)-positive tau inclusions. In neuronal culture, GCase inhibition enhances tau aggregation induced by AD-tau. Furthermore, purified GlcCer directly promotes tau aggregation in vitro. Neurofibrillary tangles in human tauopathies are also GlcCer-immunoreactive. Thus, in addition to TDP-43, PGRN regulates tau- and synucleinopathies via GCase and GlcCer. A lysosomal PGRN–GCase pathway may be a common therapeutic target for age-related comorbid proteinopathies.
Causal phase-dependent control of non-spatial attention in human prefrontal cortex
Authors: Brus Jeroen , Heng Joseph A. , Beliaeva Valeriia , Gonzalez Pinto Fabian , Cassarà Antonino Mario , Neufeld Esra , Grueschow Marcus , Imbach Lukas , Polanía Rafael
Published: February 2024

Non-spatial attention is a fundamental cognitive mechanism that allows organisms to orient the focus of conscious awareness towards sensory information that is relevant to a behavioural goal while shifting it away from irrelevant stimuli. It has been suggested that attention is regulated by the ongoing phase of slow excitability fluctuations of neural activity in the prefrontal cortex, a hypothesis that has been challenged with no consensus. Here we developed a behavioural and non-invasive stimulation paradigm aiming at modulating slow excitability fluctuations of the inferior frontal junction. Using this approach, we show that non-spatial attention can be selectively modulated as a function of the ongoing phase of exogenously modulated excitability states of this brain structure. These results demonstrate that non-spatial attention relies on ongoing prefrontal excitability states, which are probably regulated by slow oscillatory dynamics, that orchestrate goal-oriented behaviour.
The influence of climatic and environmental variables on sunflower planting season suitability in Tanzania
Authors: Beteri John , Lyimo James Godfrey , Msinde John Victor
Published: February 2024

Crop survival and growth requires identification of correlations between appropriate suitable planting season and relevant climatic and environmental characteristics. Climatic and environmental conditions may cause water and heat stress at critical stages of crop development and thus affecting planting suitability. Consequently, this may affect crop yield and productivity. This study assesses the influence of climate and environmental variables on rain-fed sunflower planting season suitability in Tanzania. Data on rainfall, temperature, slope, elevation, soil and land use/or cover were accessed from publicly available sources using Google Earth Engine. This is a cloud-based geospatial computing platform for remote sensed datasets. Tanzania sunflower production calendar of 2022 was adopted to mark the start and end limits of planting across the country. The default climate and environmental parameters from FAO database were used. In addition, Pearson correlation was used to evaluate the relationship between rainfall, temperature over Normalized Difference Vegetation Index (NDVI) from 2000 to 2020 at five-year interval for January-April and June–September, for high and poor suitability season. The results showed that planting suitability of sunflower in Tanzania is driven more by rainfall than temperature. It was revealed that intra-annual planting suitability increases gradually from short to long- rain season and diminishes towards dry season of the year. January-April planting season window showing highest suitability (41.65%), whereas June–September indicating lowest suitability (0.05%). Though, not statistically significant, rainfall and NDVI were positively correlated with r = 0.65 and 0.75 whereas negative correlation existed between temperature and NDVI with r = -− 0.6 and − 0.77. We recommend sunflower subsector interventions that consider appropriate intra-regional and seasonal diversity as an important adaptive mechanism to ensure high sunflower yields.
Effective lung nodule detection using deep CNN with dual attention mechanisms
Authors: UrRehman Zia , Qiang Yan , Wang Long , Shi Yiwei , Yang Qianqian , Khattak Saeed Ullah , Aftab Rukhma , Zhao Juanjuan
Published: February 2024

Novel methods are required to enhance lung cancer detection, which has overtaken other cancer-related causes of death as the major cause of cancer-related mortality. Radiologists have long-standing methods for locating lung nodules in patients with lung cancer, such as computed tomography (CT) scans. Radiologists must manually review a significant amount of CT scan pictures, which makes the process time-consuming and prone to human error. Computer-aided diagnosis (CAD) systems have been created to help radiologists with their evaluations in order to overcome these difficulties. These systems make use of cutting-edge deep learning architectures. These CAD systems are designed to improve lung nodule diagnosis efficiency and accuracy. In this study, a bespoke convolutional neural network (CNN) with a dual attention mechanism was created, which was especially crafted to concentrate on the most important elements in images of lung nodules. The CNN model extracts informative features from the images, while the attention module incorporates both channel attention and spatial attention mechanisms to selectively highlight significant features. After the attention module, global average pooling is applied to summarize the spatial information. To evaluate the performance of the proposed model, extensive experiments were conducted using benchmark dataset of lung nodules. The results of these experiments demonstrated that our model surpasses recent models and achieves state-of-the-art accuracy in lung nodule detection and classification tasks.
Optimising peak energy reduction in networks of buildings
Authors: Poghosyan A. , McCullen N. , Natarajan S.
Published: February 2024

Buildings are amongst the world’s largest energy consumers and simultaneous peaks in demand from networks of buildings can decrease electricity system stability. Current mitigation measures either entail wasteful supply-side over-specification or complex centralised demand-side control. Hence, a simple schema is developed for decentralised, self-organising building-to-building load coordination that requires very little information exchange and no top-down management—analogous to other complex systems with short range interactions, such as coordination between flocks of birds or synchronisation in fireflies. Numerical and experimental results reveal that a high degree of peak flattening can be achieved using surprisingly small load-coordination networks. The optimum reductions achieved by the simple schema can outperform existing techniques, giving substantial peak-reductions as well as being remarkably robust to changes in other system parameters such as the interaction network topology. This not only demonstrates that significant reductions in network peaks are achievable using remarkably simple control systems but also reveals interesting theoretical results and new insights which will be of great interest to the complexity and network science communities.