bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KINERJA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2012-2016
Authors: Pamungkas Fakhdian
Published: April 2020

This article will analyze the performance of companies traded in Indonesia Stock Exchange (BEI) from 2012 until 2016. The data source used comes from the published financial report and Indonesian Capital Market Directory (ICMD), which is a performance summary of a listed company on BEI. Analytical technique used is ratio analysis technique with horizontal method, by comparing the financial statements of several period so that will be seen growth of each bank's performance. Based on the ratio analysis, liquidity ratio, profitability, and solvency, Bank Mandiri, BNI, BRI and BCA can have good capability in fulfilling their short-term and long-term liabilities and efficiency in utilizing their assets and capitalto generate company profits. Meanwhile, Bank Mega, BRI Agroniaga and BTN can be said to lack good ability in utilizing its assets to generate profits.

 

Artikel ini akan menganalisis perkembangan kinerja perusahaan perbankan yang terdaftar di Bursa Efek Indonesia (BEI) dari tahun 2012 sampai dengan tahun 2016. Sumber data yang digunakan berasal dari laporan keuangan yang dipublikasikan serta Indonesia Capital Market Directory (ICMD), yaitu ringkasan kinerja suatu perusahaan yang terdaftar di BEI. Teknik analisis yang digunakan adalah teknik analisa rasio dengan metode horisontal, yaitu dengan membandingkan laporan keuangan beberapa periode sehingga akan terlihat perkembangan kinerja masing-masing bank tersebut.Berdasarkan analisis rasio yang dilakukan, yaitu rasio likuiditas, rentabilitas, dan solvabilitas, menunjukkan bahwa Bank Mandiri, BNI, BRI, dan BCA dapat dikatakan memiliki kemampuan yang baik dalam memenuhikewajiban-kewajiban jangka pendek dan jangka panjangnya, serta efisien dalam memanfaatkan aset dan modalnya untuk menghasilkan laba perusahaan.Sementara itu Bank Mega, BRI Agroniagadan BTN dapat dikatakan kurang memiliki kemampuan yang baik dalam memanfaatkan asetnya untuk menghasilkan laba perusahaan.
Pharmacokinetic Models to Characterize the Absorption Phase and the Influence of a Proton Pump Inhibitor on the Overall Exposure of Dacomitinib
Authors: Ruiz-Garcia Ana , Tan Weiwei , Li Jerry , Haughey May , Masters Joanna , Hibma Jennifer , Lin Swan
Published: April 2020

Introduction: Dacomitinib is an epidermal growth factor receptor (EGFR) inhibitor approved for the treatment of metastatic non-small cell lung cancer (NSCLC) in the first line in patients with EGFR activating mutations. Dacomitinib is taken orally once daily at 45 mg with or without food, until disease progression or unacceptable toxicity occurs. Oncology patients often can develop gastroesophageal reflux disease (GERD), which may require management with an acid-reducing agent. Proton pump inhibitors (PPIs), such as rabeprazole, inhibit sodium-potassium adenosine triphosphatase (H+/K+-ATPase) pumps that stimulate acid secretion in the stomach and have a prolonged pharmacodynamic effect that extends beyond 24 h post-administration. The aim of this work was to characterize the absorption of dacomitinib via modeling with a particular interest in quantifying the impact of rabeprazole on the pharmacokinetics (PK) of dacomitinib. Materials and Methods: The pooled dataset consisted of five clinical pharmacology healthy volunteer studies, which collected serial pharmacokinetic concentration-time profiles of dacomitinib. Non-linear mixed effects modeling was carried out to characterize dacomitinib pharmacokinetics in the presence and absence of the concomitant use of a PPI, rabeprazole. Several absorption models, some more empirical, and some more physiologically based, were tested: transit compartment, first-order absorption with and without lag time, and variations of combined zero- and first-order absorption kinetics models. Results: The presence of a PPI was a significant covariate affecting the extent (F) and rate (ka) of dacomitinib absorption, as previously reported in the dedicated clinical study. A transit compartment model was able to best describe the absorption phase of dacomitinib.
A novel technique for obtaining representative water samples during CO2 core-flooding experiments on chalk at reservoir conditions
Authors: Kjøller Claus , Zuta John
Published: April 2020

There is a huge potential for using CO2 gas to recover additional oil after water flooding in reservoir chalk. However, the injection of CO2 into chalk reservoirs will disturb the chemical equilibrium between formation water, injection water and chalk. A proper understanding of these CO2-induced interactions and the resulting changes in the physical properties at representative reservoir conditions is required. Unfortunately, reliable chemical data are rare because data cannot be acquired directly at reservoir conditions with present-day techniques. In published experiments, water samples are in many cases obtained at atmospheric conditions with the aid of a back-pressure regulator. Thus, water samples are not representative of in situ reservoir conditions and if proper care is not taken, the collected data cannot be used to judge the magnitude of the chemical reactions taking place at reservoir conditions. However, in some cases water obtained at laboratory conditions can give information on in situ reservoir conditions by using geochemical speciation models to account for dissolved gases that are lost from the effluents during sampling (Bachu & Adams 2003).
Earthquake swarms in Greenland
Authors: Larsen Tine B. , Voss Peter H. , Dahl-Jensen Trine , Rasmussen Hans Peter
Published: April 2020

Two earthquake swarms have been detected in Greenland. One occurred on the island of Disko in August 2010, the other one was active from January 2008 to June 2009 near the South-East Greenland coast c. 200 km south of Tasiilaq. An earthquake swarm is defined as a series of earthquakes of similar magnitude located within a small area. The magnitude of the largest earthquakes in a swarm is typically less than 4 (Ma & Eaton 2009). Swarm activity is distinctly different from the more common mainshock–aftershock activity, which is characterised by one large earthquake (mainshock) followed by a series of smaller aftershocks. Earthquake swarms mainly occur in areas with tectonic and/or volcanic activity (Stykes 1970), but intraplate swarms are also found in otherwise stable environments (Gregersen 1979; Atakan et al. 1994; Uski et al. 2006; Ma & Eaton 2009). Geological boundaries and old fault zones appear to be a common setting for intraplate earthquake swarms. Earthquake swarms have previously been detected in North and North-East Greenland (Gregersen 1979) at a time when the seismograph coverage was very sparse. It was concluded that the earthquake swarms were caused by tectonic stresses in and around old sedimentary basins near the continental margin.
The comparative analysis of 2018 Alaska earthquakes from surface wave records
Authors: Fomochkina Anastasiya , Bukchin Boris
Published: April 2020

We consider the source of an earthquake in an approximation of instant point shift dislocation. Such a source is given by its depth, the focal mechanism determined by three angles (strike, dip, and slip), and the seismic moment characterizing the earthquake intensity. We determine the source depth and focal mechanism by a systematic exploration of 4D parametric space, and seismic moment - by solving the problem of minimization of the misfit between observed and calculated surface wave spectra for every combination of all other parameters. As is well known, the focal mechanism cannot be uniquely determined from the surface wave’s amplitude spectra only. We used P-wave first arrival polarities to select the optimal solution. Ana-lyzing the surface wave spectra at shorter periods, we describe the source in an approximation of the stress glut second moments. Using these moments we determine integral estimates of the geometry, the duration of the seismic source, and rupture propagation. The results of the application of this technique for two Alaska earthquakes that occurred in 2018 (with Mw7.9 in January and with Mw7.1 in November) are presented. The possibility of the fault plane identification, which based on the obtained estimates of the focal mechanisms and second mo-ments, is analyzed for both events. Bilateral model of the source is constructed.
EVALUATION OF FEMALE STUDENTS' ATTITUDES TOWARD THE VALUE OF CITIZENSHIP FOR THE EIGHTH-GRADE BOOK OF NATIONAL AND CIVIC EDUCATION IN THE GOVERNORATE OF AJLOUN
Authors: Al-Smadi Khitam , Abd Wahid Najihah , Yunus Anas Mohd , Almomani Heyam Okleh
Published: April 2020

The paper is an attempt to evaluate female students’ attitudes towards the value of citizenship in the book of national and civic education in Jordan. It is mainly built on the key issues surrounding the book of national and civic education. The study aims to identify female students’ attitudes towards citizenship values for the eighth-grade book of national and civic education. The study population consists of (120) eighth-grade students at Anjara Elementary Girls School. They were selected by a simple random method. In order to achieve the objectives of the study, a study tool consisting of (37) items was developed, divided into two areas, values towards women and society, religious, moral and social values, and then applying pre- and post-test for control and experimental sample. The results of the study showed that there was a statistically significant difference between the average performance of female students in the experimental and control groups on the scale of students' attitudes towards the post values of citizenship traced to the teaching of national and civic education book in favor of the experimental group. The study recommended that the values of citizenship in the national and civic education book for secondary schools needs to be developed in the Hashemite Kingdom of Jordan to measure the impact of female student attitudes toward it.
Vestígios das Práticas Náuticas no Rio Grande do Sul
Authors: Silva Carolina Fernandes da , Mazo Janice Zarpellon
Published: April 2020

O presente estudo trata de como se desenvolveram as primeiras competições de esportes náuticos no Rio Grande do Sul, no início do século XIX. Na composição do corpus documental foram utilizados, principalmente, jornais que circulavam no período estabelecido nas cidades de Rio Grande, Pelotas e Porto Alegre. Estes foram analisados com o auxílio do software de análise qualitativa dos dados: ATLAS.ti 7.5.6. As primeiras manifestações de competições náuticas ocorreram nas cidades portuárias de Rio Grande, Porto Alegre e Pelotas. Com o advento de clubes, foram adotados os primeiros barcos do exterior especialmente para as regatas. Tais informações evidenciam que os clubes tiveram um papel preponderante para o estabelecimento das práticas náuticas no cenário sul-rio-grandense. Além disso, as competições esportivas foram traduzidas para a realidade sul-rio-grandense a partir do modelo europeu de regatas.
Jogos de Futebol Amador no Clube
Authors: Origuela Milena Avelaneda , Silva Cinthia Lopes da
Published: April 2020

Este trabalho tem como objetivo analisar o futebol amador em um clube da cidade de Piracicaba, tendo como foco o gênero do lazer assistência. O problema que destacamos aqui é que a assistência ao futebol é considerada como uma atividade passiva, ou apenas uma forma de consumo. No entanto, a questão deve ser revista, porque tanto a prática como a assistência podem ser ativas ou passivas, isso depende da atitude dos sujeitos. A metodologia utilizada foi pesquisa bibliográfica e de campo. As técnicas utilizadas foram observação participante e entrevistas semiestruturadas. Como resultado, identificamos que a assistência ao futebol amador no clube é parte constituinte da educação pelo lazer e pode ter implicações na educação para o lazer dos sujeitos.
Investigation of the identity of the victim in the investigation of crimes committed with the threat of violence
Authors: Makarova Elena
Published: April 2020

During the investigation of crimes, the investigator must establish all the circumstances to be proved (article 73 of the criminal procedure code), including the data on the victim. The criminalistic characterization of violent crimes will be complete only if it is supplemented with victimological features, since the personality and behavior of the victim are elements of the external environment that forms criminal intent and the choice of criminal ways to implement it. The use of victimological analysis helps the investigator to put forward versions about the offender and the motives for committing the crime, to determine the tactics of individual investigative actions, to predict the investigative situation and to timely resolve the issue of the application of security measures. In some cases, information about the victim allows to establish data on the identity of the perpetrator, the motives for committing the crime, the reasons for choosing the method of violence, etc. Data on the identity of the victim in the Commission of violent socially dangerous acts is established by forensic (technical-forensic and tactical-forensic), forensic (identification methods, anthropological), forensic-psychiatric (experimental-psychological, clinical-psychopathological) and forensic-procedural methods of cognition. On the example of the criminal cases of robberies studied by the author, it is established that the choice of the method of personality research is largely determined by the method of committing the crime and the subsequent behavior of the victim after committing a criminal act against her. Victimological aspects should be established and taken into account by the investigator during the investigation of criminal cases, the judge - when imposing punishment. Only such an approach can ensure a full, objective and comprehensive investigation of a criminal case and take the necessary preventive measures.
On the protection of property rights of minors
Authors: Ignat'eva Svetlana
Published: April 2020

Examines the existing in Russia ways to protect the rights and legitimate interests of minors in civil and family law. The practice of applying the norms of modern civil and family law when juveniles exercise their property rights is analyzed. We consider the conditions under which the protection if the rights of minors is possible both within the framework of protection and protection of property, inheritance rights of the child, rights to alimony obligations. The rights of the child to the occupied premises are considered. Various interpretations of the legal regime of property acquired for a child are investigated. Measures aimed at exercising proper control over the procedure for spending alimony of parents with whom a minor child lives are determined. The features of the legal regulation of entrepreneurial activity with the participation of minors are examined, and the issues of legal capacity and legal capacity of a minor who is an individual entrepreneur are studied. The problems and controversial moments that arise in practice when carrying out entrepreneurial activities of minors who do not have full legal capacity are identified. Discusses discussion questions regarding the age at which a citizen has the opportunity to conduct business. In this regard, a number of changes and amendments to the legislation are proposed.
FUNGSI LEMANG DALAM UPACARA PERKAWINAN SUKU BESEMAH DI KABUPATEN KAUR PROVINSI BENGKULU
Authors: REFISRUL NFN
Published: April 2020

Lemang adalah sejenis makanan yang terbuat dari beras ketan (pulut) yang dicampur dengan air kelapa (santan) serta garam, yang kemudian dimasukkan kedalam bambu yang sudah berlapis daun pisang muda, selanjutnya dimasak pada perapian yang telah disiapkan. Membuat lemang (melemang) telah menjadi tradisi pada masyarakat Besemah sejak dahulu pada waktu-waktu tertentu, seperti pada bulan puasa (Ramadhan), lebaran, maulud nabi, upacara perkawinan, panen padi, menyambut tamu dan lainnya.Keberadaan (fungsi) lemang dalam upacara perkawinan (bimbang) suku Besemah di Kabupaten Kaur merupakan fokus kajian ini.Penelitian menggunakan pendekatan kualitatif dengan sifat penelitian deskriptif analisis.Hasil penelitian menunjukkan bahwa lemang pada suku Besemah di Kabupaten Kaur menjadi unsur penting bagi keabsahan sebuah perkawinan.Lemang merupakan bawaan wajib pihak laki-laki (lanang) kepada pihak perempuan (gadis) dalam upacara perkawinan masyarakat Besemah.
ANALISIS PENGARUH KOMPETENSI TERHADAP KINERJA APARATUR SIPIL NEGARA (ASN) DI KANTOR BAPPEDA KOTA PEKANBARU
Authors: Adi Yusri Adi
Published: April 2020

Penelitian bertujuan untuk mengetahui pengaruh kompetensi terhadap kinerja aparatur sipil negara (ASN) BAPPEDA Kota Pekanbaru. Adapun jumlah responden dalam penelitian ini sebanyak 50 orang yang merupakan seluruh pegawai BAPPEDA Kota Pekanbaru. Dengan menggunakan analisis regresi sederhana hasilnya kompetensi berpengaruh secara signifikan terhadap kinerja dimana hasil uji t nya, t hitung sebesar (7,234) lebih besar nilai t tabel (1,6772) dengan tingkat signifikan 0,000 < 0,050. Adapaun nilai R square nya sebesar 0,522 artinya kompetensi menyumbangkan sebesar 52,2 % terhadap kinerja pegawai, sedangkan 47,8 % di pengaruhi oleh faktor lain.
mineração industrial e a estabilidade de assentamentos rurais no Sudeste do Estado do Pará, Brasil
Authors: Monteiro Maurílio de Abreu , Teixeira Sheila do Socorro Lima
Published: April 2020

No sudeste paraense houve o encontro de duas frentes de produção, a camponesa e a mineral, especialmente a partir da década de 1970, quando passaram a sofrer pressões e influências recíprocas. Neste contexto, o artigo analisa o papel das atividades mineradoras exercidas sobre a estabilidade da produção camponesa em quatro assentamentos localizados no município paraense de Parauapebas, Brasil. O artigo aponta que as dinâmicas decorrentes da instalação de grandes empreendimentos mineiros contribuíram para atrair populações de origem camponesa, reforçando a busca pela terra na região, retirar filhos dos assentados dos seus lotes, reduzindo a força de trabalho disponível para sustentar a produção familiar. Por outro lado, surgiram facilidades de comercialização de produtos da agricultura familiar, devido à demanda crescente. O artigo conclui indicando que, da interação com a mineração, surgem dinâmicas contraditórias no que concerne à estabilidade da produção camponesa nos assentamentos rurais estudados.
Rotatividade em assentamentos rurais
Authors: Mello Paulo Freire
Published: April 2020

Apresentamos o fenômeno da rotatividade em 193 assentamentos no Estado do Rio Grande do Sul, com ênfase na evasão de lotes. Não encontramos correlação da evasão com as variáveis relacionadas à dimensão material. Os resultados revelaram uma estimativa de 22% de evasão, porém com diferenças regionais acentuadas. O estado civil e a religião foram relacionados à evasão em duas etnografias e nos permitiram verificar que esta é estancada em situações de maior coesão social, relacionadas às relações de reciprocida- de, em especial, o parentesco, na forma da família extensa e do compadrio, e às relações religiosas e de vizinhança.
O filme “Viva Zapata”, modernização mexicana e resistência camponesa em inícios do século XX:
Authors: Nascimento Celso Gestermeier do
Published: April 2020

O artigo tem como objetivo rever formas ocultas de resistência camponesa presentes no filme Viva Zapata, de 1952, dirigido por Elia Kazan. O enredo foca a Revolução Mexicana de 1910-1919 sob o ponto de vista do revolucionário Emiliano Zapata (1879-1919), e mostra as táticas de ação cotidiana usadas contra o exército mexicano, o que tornou o exército camponês imbatível em terras de Morelos e perpetuou um mito que, ainda hoje, é referência à resistência campesina mexicana.
Pengaruh Kebijakan Publik terhadap Kualitas Pelayanan, penguatan Kelembagaan dan Kinerja Organisasi Pemerintahan
Authors: Nawi Rusdin
Published: April 2020

Rendahnya kinerja organisasi pemerintah di Indonesia terjadi karena kelembagaan yang mendukung lemah dalam aktualisasinya, menimbulkan persepsi pelayanan yang kurang berkualitas. Ini terjadi dikarenakan kebijakan publik yang diterapkan oleh instansi pemerintah tidak terformulasikan, terimplementasikan dan terevaluasikan dengan baik. yang berpengaruh terhadap kualitas pelayanan, kebijakan publik terhadap kelembagaan dan kebijakan publik terhadap kinerja organisasi.
A metrópole comunicacional 3.0
Authors: Farias Tarouco Fabricio , Gallina Jorge Gabriel
Published: April 2020

O artigo apresenta, discute e atualiza o conceito de metrópole comunicacional proposto por Massimo Canevacci, fazendo uma reflexão sobre seus desdobramentos a partir de um olhar histórico e evolutivo. Ao revisar a trajetória progressiva deste conceito, o artigo acrescenta o processo de softwarização das práticas e experiências comunicacionais presente nas cidades, e conclui dialogando sobre a smartphonização das dinâmicas urbanas que vem emergindo no contexto explorado. Considerando a conexão de cidadãos e cidade através dos apps, o artigo apresenta uma nova metrópole comunicacional tensionada pela atualização constante dos recursos tecnológicos que a conduzem, dando origem a denominação Metrópole Comunicacional 3.0.
Extended Depth of Focus Versus Monofocal IOLs: Objective and Subjective Visual Outcomes
Authors: Pedrotti Emilio , Chierego Chiara , Talli Pietro Maria , Selvi Federico , Galzignato Alice , Neri Enrico , Barosco Guido , Montresor Andrea , Rodella Anna , Marchini Giorgio
Published: April 2020

PURPOSE:

To evaluate and compare the objective and subjective outcomes between bilateral implantation of the extended depth of focus (EDOF) Mini Well intraocular lens (IOL) and the aspheric monofocal Mini-4-Ready IOL (both SIFI S.p.A., Catania, Italy).

METHODS:

This prospective comparative study included 25 patients (50 eyes) bilaterally implanted with an EDOF Mini Well IOL (EDOF group) and 25 patients (50 eyes) bilaterally implanted with a Mini-4-Ready IOL (monofocal group). Three-month follow-up data included corrected and uncorrected distance visual acuity at 4 m and 80, 67, and 40 cm. Defocus curves, subjective and objective contrast sensitivity, and objective optical quality (modulation transfer function cutoff and Strehl ratio calculated with Optical Quality Analysis System [OQAS]; Visiometrics SL, Terrassa, Spain), halometry, and reading performance were measured. Subjective visual quality was evaluated based on National Eye Institute Refractive Error Quality of Life Instrument 42 (NEI RQL-42) scores.

RESULTS:

Postoperative uncorrected and corrected monocular and binocular intermediate and near visual acuity was significantly better in the EDOF group (
P
< .001). No differences were observed for distance visual acuity (
P
⩾ .312). Defocus curve outcomes for myopic values were better in the EDOF group (
P
< .001). No significant differences were found in hyperopic (obtained in steps of +0.50 diopters [D] from emmetropia to 1.50 D) values (
P
⩾ .095), contrast sensitivity curves (
P
⩾ .087), or OQAS outcomes (
P
⩾ .138). Halometric values were significantly better in the monofocal group (
P
< .05). There was a correlation between mean keratometry values and intermediate/near visual acuity. Significantly better NEI RQL-42 subscale scores for near vision, far vision, activity limitations, glare, dependence on correction, and suboptimal correction were noted in the EDOF group (
P
< .05).

CONCLUSIONS:

Intermediate and near visual acuity was better after EDOF IOL than after aspheric monofocal IOL implantation while maintaining similar levels of visual quality, except for halo perception.

[
J Refract Surg
. 2020;36(4):214–222.]
Development of Projo Bale Model Based on Android Application in History and Local Wisdom Studies of Malang
Authors: Sayono Joko , Jauhari Najib , Ayundasari Lutfiah , Sulistyo Wahyu Djoko
Published: April 2020

Lack of research development on history and local wisdom studies of Malang and its integration in learning acitivities is the background of the development of Projo Bale model. Local history is full of relevant local wisdom values to be implanted in learners. The history department as the institution that produce history teachers should teach students with knowledge about local history at least the area of Malang. This Model was compiled in response to the problem. The collaboration between Outdoor Learning and Project Based Learning models with Android app based is a creative effort to leverage technology in historical learning innovations. The stages in this development include 5 phases ranging from analysis, development, design, implementation and evaluation. In the final stage of the evaluation of the model post implementation reached an average figure of 82.75% indicating this model is viable and effective as an innovative model in the study of history.
Cluster Analysis of Patients’ Clinical Information for Medical Practitioners and Insurance Companies
Authors: Memon Qurban A , Hassan Mohammad E
Published: April 2020

A number of approaches have been proposed in literature to collect and classify patient related information for purpose of better clinical diagnosis and thus safer treatment and administration of related activities. This type of data collection and classification benefits doctors and the corresponding hospitals. However, no effort is made, as to our knowledge, to classify accumulated data within insurance company databases to facilitate doctors as well as insurance companies for better analysis and cost-effective treatment of patients suffering from chronic (and expensive to treat) diseases such as related to oncology. In this study, a customized self-organized data classification model is applied to an insurance company database to build clusters based on age, patient condition, tests done, etc. These clusters provide integrated analysis to doctors in providing patient-specific, disease-specific, etc., and thus cost-effective treatment. On the other side, it saves on costs to be incurred on repeated tests to be done on the patient. An experimental setup is developed to train such a network, and testing results are presented. The practical constraints are also discussed.
Renal Involvement at Diagnosis of Pediatric Acute Lymphoblastic Leukemia
Authors: Prada-Rico Mayerly , Rodríguez-Cuellar Carmen Inés , Arteaga Aya Lucy Natalia , Nuñez Chates Claudia Lorena , Garces Sterling Sandra Patricia , Pierotty Mathieu , Gonzalez Chaparro Luz Esthella , Gastelbondo Amaya Ricardo
Published: April 2020

Acute leukemia is the most common type of cancer in pediatric patients. This type of cancer accounts for a third of all childhood cancer cases. More than half of pediatric acute leukemia patients show signs and symptoms such as hepatomegaly, splenomegaly, pallor, fever and bruising at the time of diagnosis. In early stages of acute lymphoblastic leukemia (ALL), nephromegaly and other renal manifestations such as high blood pressure (HBP) and renal failure are uncommon, although renal infiltration and nephromegaly are common in advanced-stage pediatric patients. This is a retrospective case review with a critical appraisal of the existing evidence from the literature. We present a clinical case of a child with HBP associated with bilateral nephromegaly which resolved after chemotherapy treatment. This patient presented with HBP that required pharmacological treatment, likely owing to nephromegaly. All HBP secondary causes were rejected. Nephromegaly was resolved after chemotherapy treatment, and antihypertensive medication was discontinued. Nephromegaly and HBP are rare manifestations of ALL debut in pediatrics. The present case report illustrates this unusual combination and Suggests clinicians to consider malignancy as its causal factor, especially if the symptoms are accompanied by other suggestive extrarenal manifestations.
DOI: identificação para artigo - ORCID: DOI para autor
Authors: Horner Andreas , Horner Christine , Machado Catrine De Souza
Published: April 2020

O Digital Object Identifier (DOI)® é um identificador internacionalmente aceito, traduzido como “Identificador Digital de Objetos”, principalmente para documentos digitais1. O sistema DOI foi proposto em 1996 porém iniciou em 1998 pela International DOI Foundation2 com o objetivo principal de dar estabilidade na localização de documentos no ambiente da internet. "Open Researcher and Contributor Identification " (ORCID) é um identificador digital persistente para o autor que está para o autor assim como o DOI está para um documento digital, no caso o artigo po­dendo ser ligado a vários outros tipos de produção de pesquisa, incluindo, livros, teses, eventos, relatórios técnicos, entre outros.
The Influence of Clinical Practicum-related Stress, and Awareness, and Self-efficacy on Strength on Health Promotion Behaviors among Nursing Students
Authors: Lee Si Jin , Lee Ji Eun , Lee Myung Kyung
Published: April 2020

Purpose: This study was conducted to identify the influence of clinical practicum-related stress, and awareness, and self-efficacy on strength on health promotion behaviors among nursing students. Methods: The subjects were 274 students in nursing college who had experience in a clinical nursing practicum. Data were collected from self-reported questionnaires and were analyzed by independent t-test, ANOVA, Pearson correlation coefficient, and multiple regression analyses. Results: Multiple regression analyses showed that strength self-efficacy and self-awareness on strength significantly affected overall health promotion behaviors. Regarding subscales of health promotion behaviors, self-awareness on strength significantly affected health responsibility and stress management in health promotion behavior when controlling for sociodemographic characteristics, while the subscales of clinical practicum-related stress did not affect health promotion behavior. Conclusion: The recognition of an individual's strength and self-efficacy might be a factor in improving health promotion behaviors among nursing college students, although they suffer from stress during clinical nursing practicum.
Diseño de interfa…¿qué?
Authors: Monjo Tona , Fàbregas Cristina
Published: April 2020

Después de compartir el proceso de reconceptualización de la arquitetura de la información de Mosaic, abordamos la fase siguiente, la concreción de la línea gráfica y el diseño de la interfaz.
Lali Masriera
Authors: Rodríguez René , Albadalejo Carlos , Casado Martínez Carlos
Published: April 2020

Diseñadora gráfica y fotógrafa, Lali Masriera nos habla en esta entrevista sobre su experiencia en el diseño de sitios web para empresas e instituciones, así como para weblogs. Masriera señala que la base de toda creación gráfica es el color, la composición, la luz y la forma, pero para ella un diseñador no debe dejar de lado aspectos tales como la tecnología y el marketing.
Electrohydrodynamic Jet Printing – Principles and Applications in High Sensitivity Biosensing
Authors: Zheng Gaofeng , Jiang Jiaxin , Chen Huatan , Kang Guoyi , Wang Xiang , Li Wenwang , Lin Liwei
Published: April 2020

This article focuses biosensors based on the electrohydrodynamic jet printing processes, including the fabrication process, micro/nano‐material characteristics, and the sensing principle. Electrohydrodynamic jet printing provides a novel way to fabricate micro/nano‐structures for flexible/wearable biosensors with excellent characteristics of low detection limits, high sensitivities, and fast responses. The nonwoven nanofibrous mats have been used as support substrates, detection elements, and sensor electrodes to enhance the sampling, reaction, and detection in the biosensing processes. Large‐scale electrospinning techniques are discussed to efficiently produce nanofibers for the industrial nanofiber applications. The near‐field electrospinning technique is also introduced which can overcome the bending instability in the nanofiber deposition process to make orderly nanofibrous patterns as the sacrificial structure for the fabrication of microfluidic chips as bioreactor chambers. The functional nanofibers increase the biosensing interfaces and sensing sensitivity with good flexibility to realize applications such as the vital signs detection for the fields of disease diagnosing, infection control, and health care. With these great advantages, electrohydrodynamic jet printing provides new opportunities for the development of point of care medical.
Intravenous Anakinra for Macrophage Activation Syndrome May Hold Lessons for Treatment of Cytokine Storm in the Setting of Coronavirus Disease 2019
Authors: Wampler Muskardin Theresa L.
Published: April 2020

Macrophage activation syndrome (MAS) and hemophagocytic lymphohistiocytosis (HLH) are increasingly recognized as being on a continuum of cytokine storm syndromes, with different initiating pathways culminating in cytotoxic dysfunction and uncontrolled activation and proliferation of T lymphocytes and macrophages. The activated immune cells produce large amounts of proinflammatory cytokines, including interleukin 1β (IL)‐1β. Management depends on the recognized diagnosis. In the setting of a cytokine storm syndrome and infection, collaborative involvement of specialists, including infectious disease and rheumatology is ideal. Anakinra, a recombinant IL‐1 receptor antagonist, has been used subcutaneously and intravenously in pediatric patients and is considered a first‐line treatment for MAS and secondary HLH (sHLH) among many pediatric rheumatologists. Previous reports of anakinra used in adults for treatment of MAS or sHLH are limited to subcutaneous administration. In this issue, Moneagudo et al. present a series of adult patients with sHLH treated with intravenous anakinra, including patients in whom subcutaneous anakinra was insufficient. As the authors suggest, there is a potential therapeutic use for anakinra in sHLH or the cytokine storm syndrome triggered by COVID19. Trial design will be key, with the patient subpopulation, timing of intervention, and doses tested important.
Modeling and Emulating a Physiotherapist's Role in Robot‐Assisted Rehabilitation
Authors: Tao Ran , Ocampo Renz , Fong Jason , Soleymani Abed , Tavakoli Mahdi
Published: April 2020

In home‐based rehabilitation, one possible approach is haptic teleoperation in which a hospital‐based therapist is haptically linked and tele‐presented to a home‐based patient to effectively simulate traditional in‐hospital therapies over a distance. In this context, this article proposes a learn‐and‐replay (LAR) paradigm that consists of two phases: a therapist‐in‐loop (interactive) phase where the therapist interacts through the haptic teleoperation loop with the patient to perform the cooperative therapy task, and a therapist‐out‐of‐loop (standalone) phase where the therapist's task is played by the patient‐side robot in future repetitions. During the interactive phase, the therapist demonstrates impedance during cooperating with the patient. During the standalone phase, the patient‐side robot is automatically controlled to mimic the therapist's demonstrated impedance which is learned in the interactive phase. The direct force reflection (DFR) architecture is utilized as the control method for the bilateral telerehabilitation system. Case studies involving 1‐degree‐of‐freedom and 2‐degree‐of‐freedom cooperative manipulation tasks are tested for proof of concept. The results show that the impedance of the therapist's arm can be replicated by the patient‐side robot for both tasks and proposed LAR telerehabilitation paradigm that assists the therapist in the rehabilitation procedure to take care of other tasks or attend to other patients.
Super‐macroporous composite cryogels based on biodegradable dextran and temperature‐responsive poly(N‐isopropylacrylamide)
Authors: Georgiev Georgy L. , Borisova Dayana , Petrov Petar D.
Published: April 2020

This contribution describes the fabrication of super‐macroporous cryogels comprising an interpenetrating network of biodegradable dextran and temperature‐responsive poly(N‐isopropylacrylamide) (PNIPAAm) segments. Cryogels were prepared from nonmodified dextran and N‐isopropylacrylamide (NIPAAm) via cryogenic treatment of their aqueous solutions and subsequent irradiation with Ultraviolet light. The weight ratio of the two precursors was varied in order to find out the proper conditions for producing cryogels of high gel fraction yield and favorable physico‐mechanical properties. Temperature‐responsive behavior and enhanced elastic modulus were established for cryogel materials containing ≥50 wt% PNIPAAm. Scanning electron microscopy study revealed an open‐porous structure of cryogels below and above the temperature of volume phase transition. Such morphology featured a very quick response of the material to temperature changes. The capability of dextran/PNIPAAm cryogels for instant release of water‐soluble substances was demonstrated as well.
Conservation of freshwater macroinvertebrate biodiversity in tropical regions
Authors: Sundar S. , Heino Jani , Roque Fabio de Oliveira , Simaika John P. , Melo Adriano S. , Tonkin Jonathan D. , Gomes Nogueira Davidson , Silva Daniel Paiva
Published: April 2020

Motivated by recent global initiatives for biodiversity conservation and restoration, this article reviews the gaps in our understanding of, and the challenges facing, freshwater macroinvertebrate biodiversity and conservation in tropical regions.

This study revealed a lack of adequate taxonomic, phylogenetic, and ecological information for most macroinvertebrate groups, and consequently there are large‐scale knowledge gaps regarding the response of macroinvertebrate diversity to potential climate change and other human impacts in tropical regions.

We propose ideas to reduce the impact of key drivers of declines in macroinvertebrate biodiversity, including habitat degradation and loss, hydrological alteration, overexploitation, invasive species, pollution, and the multiple impacts of climate change.

The review also provides recommendations to enhance conservation planning in these systems (as well as providing clear management plans at local, regional, and national levels), integrated catchment management, the formulation of regulatory measures, the understanding of the determinants of macroinvertebrate diversity across multiple scales and taxonomic groups, and the collaboration between researchers and conservation professionals.

It is suggested that the integrated use of macroinvertebrate biodiversity information in biomonitoring can improve ecosystem management. This goal can be facilitated in part by conservation psychology, marketing, and the use of the media and the Internet.
Weiterentwicklung der Energieeinsparverordnung
Authors: Schöndube Tim , Beecken Christoph , Becker Sabine , Carrigan Svenja , Kornadt Oliver
Published: April 2020

Die wesentlichen Anforderungen an die energetische Qualität von Gebäuden werden in Deutschland bisher in der Energieeinsparverordnung (EnEV) formuliert. In absehbarer Zeit wird die EnEV durch das Gebäudeenergiegesetz (GEG) ersetzt. Beiden Regelwerken ist gleich, dass lediglich der Energiebedarf, resultierend aus der Nutzungsphase eines Gebäudes, zu bilanzieren ist. Der Energieaufwand für die Herstellung und Instandhaltung von Gebäuden sowie für den Rückbau und die Entsorgung von veralteten Gebäudekomponenten wird dabei außer Acht gelassen. In der Vergangenheit war diese Einschränkung vertretbar. Mit der Entwicklung hocheffizienter Gebäude sinkt jedoch der Energiebedarf in der Nutzungsphase in hohem Maße und eine Neubewertung ist erforderlich. Wissenschaftliche Untersuchungen am Beispiel eines Ein‐ und eines Mehrfamilienhauses, welche die aktuellen Anforderungen der EnEV erfüllen, haben ergeben, dass über einen Zeitraum von 50 Jahren die Herstellungs‐ und Instandhaltungsphase zusammen einen Anteil von 30 % (EFH) bzw. 38 % (MFH) des gesamten Primärenergiebedarfs, nicht erneuerbar verursacht. Für diesen Anteil sind jedoch bisher keine gesetzlichen Vorgaben zu beachten. Es sind somit über die Gebäudenutzungsphase hinaus erhebliche Einsparpotenziale im Baubereich vorhanden. Zur Aktivierung dieser Potenziale werden im Rahmen dieses Artikels Ansätze zur Berücksichtigung der Herstellungs‐, Nutzungs‐ und Instandhaltungsphase bei der energetischen Bewertung von Gebäuden vorgestellt.
Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR‐646/BCL‐2 axis
Authors: Chen Nan‐nan , Chao Dai‐ling , Li Xiu‐gui
Published: April 2020

Retinoblastoma (RB) is one of the most common primary intraocular malignancies in children. Emerging researches have shown that circular RNAs (circRNAs) play critical roles in a variety of cancers. As a novel circRNA, the function of circ_0000527 in RB remains unknown. In this work, expression level of circ_0000527 and miR‐646 in RB tissues and cell lines were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). RB cell lines (SO‐Rb50 and WERI‐Rb‐1) were used as cell models in functional experiments. CCK‐8 assay, TUNEL assay and transwell assay were employed to detect the biological influence of circ_0000527 and miR‐646 on cancer cells in vitro. qRT‐PCR, luciferase reporter assay, RIP assay and western blot were used for exploring the interactions among circ_0000527, miR‐646 and BCL‐2. It was demonstrated that expression level of circ_0000527 in RB samples was significantly up‐regulated compared to normal tissues, while miR‐646 was markedly down‐regulated. Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR‐646 transfection had the opposite effects. Circ_0000527 sponged miR‐646 to regulate the expression of BCL‐2. In conclusion, circ_0000527 could promote the development of RB by indirectly modulating BCL‐2 via absorbing miR‐646.

Significance of the study

Expression level of circ_0000527 in RB samples was significantly up‐regulated compared to normal tissues, while miR‐646 was markedly down‐regulated. Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR‐646 transfection had the opposite effects. Circ_0000527 sponged miR‐646 to regulate the expression of BCL‐2.
Vanadium–Manganese Redox Flow Battery: Study of MnIII Disproportionation in the Presence of Other Metallic Ions
Authors: Reynard Danick , Maye Sunny , Peljo Pekka , Chanda Vimanshu , Girault Hubert H. , Gentil Solène
Published: April 2020

The MnIII/MnII redox couple with a standard potential of +1.51 V versus the standard hydrogen electrode (SHE) has attracted interest for the design of V/Mn redox flow batteries (RFBs). However, MnIII disproportionation leads to a loss of capacity, an increase in pressure drop, and electrode passivation caused by the formation of MnO2 particles during battery cycling. In this work, the influence of TiIV or/and VV on MnIII stability in acidic conditions is studied by formulating four different electrolytes in equimolar ratios (Mn, Mn/Ti, Mn/V, Mn/V/Ti). Voltammetry studies have revealed an ECi process for MnII oxidation responsible for the electrode passivation. SEM and XPS analysis demonstrate that the nature and morphology of the passivating oxides layer depend strongly on the electrolyte composition. Spectroelectrochemistry highlights the stabilization effect of TiIV and VV on MnIII. At a comparable pH, the amount of MnIII loss through disproportionation is decreased by a factor of 2.5 in the presence of TiIV or/and VV. Therefore, VV is an efficient substitute for TiIV to stabilize the MnIII electrolyte for RFB applications.
Determinants of quality of life in patients with incurable cancer
Authors: Daly Louise E. , Dolan Ross D. , Power Derek G. , Ní Bhuachalla Éadaoin , Sim Wei , Cushen Samantha J. , Fallon Marie , Simmons Claribel , McMillan Donald C. , Laird Barry J. , Ryan Aoife M.
Published: April 2020

Background

Optimizing quality of life (QoL) remains the central tenet of care in patients with incurable cancer; however, determinants of QoL are not clear. The objective of the current study was to examine which factors influence QoL in patients with incurable cancer.

Methods

A multicenter study of adult patients with advanced cancer was conducted in Ireland and the United Kingdom between 2011 and 2016. Data were collected from patients at study entry and included patient demographics, Eastern Cooperative Oncology Group performance status (ECOG‐PS), nutritional parameters (the percentage weight loss [%WL]), muscle parameters assessed using computed tomography images (skeletal muscle index and skeletal muscle attenuation), inflammatory markers (modified Glasgow Prognostic score [mGPS]), and QoL data (the European Organization for Research and Treatment Quality‐of‐Life Questionnaire C‐30). The relation between clinical, nutritional, and inflammatory parameters with QoL was assessed using the Spearman rank correlation coefficient and multivariate binary logistic regression. Components of the European Organization for Research and Treatment Quality‐of‐Life Questionnaire C‐30 (physical function, fatigue, and appetite loss) and summary QoL scores were mean‐dichotomized for the logistic regression analyses.

Results

Data were available for 1027 patients (51% men; median age, 66 years). Gastrointestinal cancer was most prevalent (40%), followed by lung cancer (26%) and breast cancer (9%). Distant metastatic disease was present in 87% of patients. The %WL, ECOG‐PS, and mGPS were significantly correlated with deteriorating QoL functional and symptom scales (all P < .001). On multivariate regression analysis, >10% WL (odds ratio [OR], 2.69; 95% CI, 1.63‐4.42), an ECOG‐PS of 3 or 4 (OR, 14.33; 95% CI, 6.76‐30.37), and an mGPS of 2 (OR, 1.58; 95% CI, 1.09‐2.29) were independently associated with poorer summary QoL scores. These parameters were also independently associated with poorer physical function, fatigue, and appetite loss (all P < .05). Low skeletal muscle attenuation was independently associated with poorer physical functioning (OR, 1.67; 95% CI, 1.09‐2.56), but muscle parameters were not independently associated with fatigue, appetite loss, or QoL summary scores.

Conclusions

The current findings indicate that QoL is determined (at least in part) by WL, ECOG‐PS, and the systemic inflammatory response in patients with advanced cancer. Identifying early predictors of poor QoL may allow the identification of patients who may benefit from early referral to palliative and supportive care, which has been shown to improve QoL.