bluuebunny/crossref_metadata_2025 huggingface dataset:
FROM REJECTION TO CONFRONTATION: A STUDY ON THE ONTOLOGICAL SECURITY PERSPECTIVE OF POLAND’S RELATIONS WITH RUSSIA
Authors:   School of International Relations and Public Affairs, Shanghai International Studies University, Shanghai, China, Yan KE
Published: June 2024

In the field of international security studies, attention to ontological security issues has become a focal point. Ontological security at the national level manifests as the dynamic harmony between“national super-ego” and “national Id”, representing a common product in the subject relations. Ontological security crisis is the result of the failure of “national ego” regulation. Positioned in the geopolitical periphery, Poland, over millennia, has developed a distinct“national super-ego” and a strong sense of identity. However, throughout its history, Poland has repeatedly faced ontological security challenges from Russia. For Poland, Russia has transformed from being the “other” to the “excluded”, ultimately becoming the “adversary” in Poland's ontological security. Since the “post-Cold War” era, Poland has endeavored to reshape its ontological security through internal and external measures. Ontological security provides a novel perspective for international relations research.
Theory of Relationships between Spaces to Obtain Numerical Knowledge
Authors: Cardoso Carlos Eduardo Ramos
Published: June 2024

The theory says that number interacts with spaces based on the meaning of mathematics, in this way it is possible to obtain numerical knowledge. The theory shows the possibility of using spaces related to each other to explain the reasons why two even numbers form a pair, two odd numbers form a pair, an even number and an odd number form an odd number, three odd numbers form an odd number . three even numbers make an odd number. an even, an odd and two evens make an odd, two odd and an even make a pair. Furthermore, it is possible to extend the logic to larger numbers, but applying rules to make it work.
A City Shared Bike Dispatch Approach Based on Temporal Graph Convolutional Network and Genetic Algorithm
Authors: Ma Ji , Zheng Shenggen , Lin Shangjing , Cheng Yonghong
Published: June 2024

Public transportation scheduling aims to optimize the allocation of transportation resources, enhance transportation efficiency, and increase passenger satisfaction, which is crucial for building a sustainable urban transportation system. As a complement to public transportation, shared bikes provide users with a solution for the last mile of travel, compensating for the lack of flexibility in public transportation and helping to improve its utilization rate. Due to the characteristics of shared bikes, such as peak usage periods in the morning and evening and significant fluctuations in demand across different areas, the optimization of shared bike dispatch can better meet user needs, thereby reducing vehicle vacancy rates and increasing operating revenue. Addressing this issue, this paper designs a comprehensive decision-making approach for spatio-temporal demand prediction and bike dispatch optimization. For demand prediction, we designed a T-GCN based bike demand prediction model. In terms of dispatch optimization, we considered factors such as dispatch capacity, distance restrictions, and dispatch costs, and designed an optimization solution based on genetic algorithms. Finally, this paper validates the approach using shared bike operating data, shows that T-GCN can effectively predict short-term demand for shared bikes. Meanwhile, the optimization model based on genetic algorithms provides a complete dispatch solution verifying the model’s effectiveness. The shared bike dispatch approach proposed in this paper, which combines demand prediction with resource scheduling. This scheme can also be extended to other transportation scheduling problems with uncertain demand, such as store replenishment delivery and intercity inventory dispatch.
Unlocking Prognostic Potential: A Genomic Signature of Caloric Restriction in Patients With Epithelial Ovarian Cancer
Authors: Tal Ori , Zahavi Tamar , Sinberger Liat Anabel , Salmon-Divon Mali
Published: June 2024

Epithelial ovarian cancer significantly contributes to cancer-related mortality in women, often recurring post-treatment with chemotherapy resistance. Dietary interventions have demonstrated influence on cancer progression; for instance, caloric restriction has exhibited tumor growth reduction and enhanced survival in animal cancer models. This study aims to calculate a transcriptomic signature based on caloric-restriction for ovarian cancer patients and explore its correlation with disease progression. We identified proteins modulated by fasting, intermittent fasting or caloric restriction in human females. Based on their gene expression, we calculated a Non-Fasting Genomic Signature score for ovarian cancer samples from the TCGA database. We examined the association between this genomic profile and clinical characteristics. The non-fasting signature, comprising eight genes, demonstrated higher prevalence in primary ovarian tumors compared to normal tissue. Patients with elevated signature expression exhibited reduced overall survival and increased lymphatic invasion. The mesenchymal subtype, associated with chemotherapy resistance, displayed the highest signature expression. Multivariate analysis suggested the non-fasting genomic signature as a potential independent prognostic factor. Ovarian cancer tumors expressing a “non-fasting” transcriptional profile correlate with poorer outcomes, emphasizing the potential impact of caloric restriction on improving patient survival and treatment response. Further investigations, including clinical trials, are warranted to validate these findings.
Ratanjot (Alkanna tinctoria L.) Root Extract, Rich in Antioxidants, Exhibits Strong Antimicrobial Activity Against Foodborne Pathogens and Is a Potential Food Preservative
Authors: Das Annada , Biswas Subhasis , Satyaprakash Kaushik , Bhattacharya Dipanwita , Nanda Pramod , Patra Gopal , Moirangthem Sushmita , Nath Santantu , Dhar Pubali , Verma Arun , Biswas Olipriya , Tardi Nicole Irizarry , Bhunia* Arun K. , Das* Arun K.
Published: June 2024

Natural and sustainable plant-based antioxidants and antimicrobials are highly desirable for improving food quality and safety. The present investigation assessed the antimicrobial and antioxidant properties of active components from Alkanna tinctoria (herb) roots, also known as Ratanjot root. Two methods were used to extract active components: microwave-assisted hot water (MAHW) and ethanol and air-dried. MAHW extract yielded 6.29% while the ethanol yielded 18.27%, suggesting superior Ratanjot root extract powder (RRP) solubility in ethanol over water. The ethanol extract showed significantly higher antioxidant activity than the MAHW extract. Gas chromatography and mass-spec analysis revealed three major phenolic compounds: Butanoic acid, 3-hydroxy-3-methyl-; Arnebin 7, and Diisooctylpthalate. The color attributes (L*, a*, b*, hab, C*ab) for the ethanolic and MAHW extracts revealed significant differences (P < 0.05) in all the above parameters for both types of extracts, except for yellowness (b*) and chroma (C*ab) values. The ethanol extract exhibited antimicrobial activity against 14 bacterial species, with a signifi-cantly higher inhibitory effect against Gram-positive bacteria (Listeria monocytogenes and Staphylococcus aureus) than the Gram-negative bacteria (Salmonella enterica serovar Typhimurium and Escherichia coli). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were both 25 mg/ml for the Gram-negative bacteria, while the MIC and MBC concentrations varied for Gram-positive bacteria (0.049 - 0.098 mg/ml and 0.098 - 0.195 mg/ml) and the antimicrobial effect was bactericidal. The antimicrobial activities of RRP extract remained stable under broad temperature (37-100°C) and pH (2-6) conditions, as well as during refrigerated storage for 30 days. Application of RRP at 1% (10 mg/g) and 2.5% (25 mg/g) levels in a cooked chicken meatball model system prevented lipid oxidation and improved sensory attributes and retarded microbial growth during refrigerated (4°C) storage for 20 days. Furthermore, the RRP extract was non-toxic when tested with sheep erythrocytes and did not inhibit the growth of probiotics, Lacticaseibacillus casei, and Lactiplantibacillus plantarum. In conclusion, the study suggests that RRP possesses excellent antimicrobial and antioxidant activities, thus making it suitable for food preservation.
A Hybrid Stacking Model for Enhanced Short-Term Load Forecasting
Authors: Guo Fusen , Mo Huadong , Wu Jianzhang , Pan Lei , Zhou Hailing , Zhang Zhibo , Li Lin , Huang Fengling
Published: June 2024

The high penetration of distributed energy resources poses significant challenges to the dispatch and operation of power systems. Improving the accuracy of short-term load forecasting (STLF) can optimize grid management, leading to increased economic and social benefits. Currently, some simple AI and hybrid models has issues to deal with and struggle with multivariate dependencies, long-term dependencies, and non-linear relationships. This paper proposes a novel hybrid model for short-term load forecasting (STLF) that integrates multiple AI models with Lasso regression using the stacking technique. The base learners include ANN, XgBoost, LSTM, Stacked LSTM, and Bi-LSTM, while Lasso regression serves as the meta-learner. By considering factors such as temperature, rainfall, and daily electricity prices, the model aims to more accurately reflect real-world conditions and enhance predictive accuracy. Empirical analyses on real-world datasets from Australia and Spain show significant improvements in forecasting accuracy, with a substantial reduction in Mean Absolute Percentage Error (MAPE) compared to existing hybrid models and individual AI models. This research highlights the efficiency of the stacking technique in improving STLF accuracy, suggesting potential operational efficiency benefits for the power industry.
Investigation of the Potential of Concomitant Radiation Therapy and Gold Nanoparticles for Pancreatic Cancer
Authors: Martins Alexandra , Ferreira Brigida Costa , Gaspar Manuela , Vieira Sandra , Lopes Joana , Viana Ana S , Paulo António , Mendes Filipa , Campello Maria Paula Cabral , Martins Rui , Reis Catarina Pinto
Published: June 2024

The present work consisted of an exploratory study aiming to evaluate in vitro the potential of AuNPs during Radiation Therapy (RT) in human pancreatic adenocarcinoma cells. AuNPs coated with hyaluronic and oleic acids (HAOA-AuNPs) or with bombesin peptides (BBN-AuNPs) were used. AuNPs were characterized by Atomic Force Microscopy (AFM) and Dynamic Light Scattering. BxPC-3 tumour cells were irradiated with a 6 MV X-rays beam, in the absence or presence of AuNPs. AFM showed that HAOA-AuNPs and BBN-AuNPs are spherical with a mean size of 83+-20 nm and 49+-12 nm, respectively. For RT alone, a reduction in cell viability of up to 33+-12% was obtained compared to the control (p ≤ 0.0001). HAOA-AuNPs alone at 200 and 400 μM showed a reduction in cell viability of 20+-4% and 35+-4%, respectively, while for BBN-AuNPs, at 50 and 200 μM, a reduction in cell viability of 25+-3% and 37+-3% was obtained, respectively, compared to the control (p < 0.0001). At 72 h post-irradiation, a decrease in cell viability of 26+-3% and 22+-2% between RT+HAOA-AuNPs at 400 μM and RT+BBN-AuNPs at 50 μM, compared to RT alone, was obtained (p < 0.004). The combination of RT with AuNPs led to a significant decrease in cell viability compared to the control, or RT alone, thus representing an improved effect.
Converting Candlenut Shell Waste into Graphene for Electrode Applications
Authors: Siburian Rikson , Tarigan Kerista , Manik Yosia Gopas Oetama , Hutagalung Fajar , Alias Yatimah , Chan Yong Ching , Chang Boon Peng , Siow Jonathan , Ong Amanda Jiamin , Huang Jingfeng , Paiman Suriati , Goh Boon Tong , Simatupang Lisnawaty , Goei Ronn , Tok Alfred Iing Yoong , Raja Yahya Mohd Fakharul Zaman , Bahfie Fathan
Published: June 2024

Graphene was synthesized through a two-step pyrolysis method using waste candlenut (Aleurites moluccanus) shells as the precursor. Cerium (Ce)/graphene composites were prepared via an impregnation technique. The resulting graphene and Ce/graphene were characterized using various analytical methods, including Scanning Electron Microscopy with Energy-Dispersive Spectroscopy (SEM-EDS), X-ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Transmission Electron Microscopy (TEM), Thermo Gravimetric Analysis (TGA), Fourier Transform Infrared (FTIR) spectroscopy, Cyclic Voltammetry (CV), and Linear Sweep Voltammetry (LSV). The bio-carbon produced predominantly exhibited a graphene structure with flat carbon morphology and an interlayer distance of 0.33 nm. This structural information is supported by XRD data, which shows a broad and weak peak at 2θ = 26° corresponding to the C (002) plane, indicative of graphene presence. FTIR, XPS, and Raman spectroscopy further confirmed the presence of graphene through the detection of Csp2 aromatic bonds and the characteristic D, G, and 2D peaks. Notably, the performance of cerium can be enhanced by the incorporation of graphene, attributed to the large surface area and chemical interactions between Ce and graphene. Consequently, candlenut-derived graphene shows potential as a supportive material for modifying the properties of cerium, thereby opening avenues for various advanced applications, such as sustainable and high-performance energy storage systems.
Modeling Short-Term Energy Consumption Forecasting with External Influences: A Comprehensive Study
Authors: Amaral Leonardo , Araújo Gustavo , Moraes Ricardo , Vasques Francisco , Portugal Paulo
Published: June 2024

Short-term energy consumption forecasting crucial for the operation of new electrical en-ergy grids, not only due to their own characteristics, but also due to the new elements pre-sent in the energy matrix. Many existing models are limited by their methodologies or by considering only a narrow set of factors influencing energy consumption. This study in-troduces a pipeline for developing an energy forecasting model and evaluates the signifi-cance of factors affecting energy consumption and, consequently, forecast accuracy. The study utilizes a dataset from ISO NE (Independent System Operator New England), span-ning the total electric load of various cities in New England from January 2017 to December 2019. This dataset comprises 23 independent variables, including weather data, economic indicators, and market information. The results outline the steps involved in constructing energy forecast models using time series analysis. By carefully selecting variables and rep-resenting external factors, the study demonstrates the feasibility of generating more accu-rate predictions with reduced computational resources.
Sex aspects in lipoprotein metabolism, dyslipidemia, and lipid-lowering therapy: A comprehensive review
Authors: Zimodro Jakub Michal , Mucha Magda , Berthold Heiner K. , Gouni-Berthold Ioanna
Published: June 2024

Lipid-lowering therapy (LLT) is a cornerstone of atherosclerotic cardiovascular disease prevention. Although LLT might lead to different reductions in low-density lipoprotein cholesterol (LDL-C) levels in women and men, LLT diminishes cardiovascular risk equally effectively in both sexes. Despite similar LLT efficacy, the use of high-intensity statin, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors is lower in women compared to men. Women achieve the guideline-recommended LDL-C levels less often than men. Greater cholesterol burden is particularly prominent in women with familial hypercholesterolemia. In clinical practice, women and men with dyslipidemia present with different cardiovascular risk profiles and disease manifestations. The concentrations of LDL-C, lipoprotein(a) and other blood lipids differ between women and men over a lifetime. Dissimilar levels of LLT’s target molecules partially result from sex-specific hormonal and genetic determinants of lipoprotein metabolism. Hence, to evaluate a potential need for sex-specific LLT, this comprehensive review (i) describes the impact of sex on lipoprotein metabolism and lipid profile, (ii) highlights sex differences in cardiovascular risk among patients with dyslipidemia, (iii) presents recent, up-to-date clinical trial and real-world data on LLT efficacy and safety in women, and (iv) discusses diverse medical needs of women and men with dyslipidemia and increased cardiovascular risk.
Cytomegalovirus Cause Congenital Hearing Loss by Regulating the Signaling Pathways in Developing Peripheral Auditory Organ
Authors: Liu Xiaozhou , Zhao Zhengdong , Shi Xinyu , Zong Yanjun , Sun Yu
Published: June 2024

Cytomegalovirus infection contributes to 10-30% congenital hearing loss in children. Vertebrate peripheral auditory organs include the outer, middle and inner ear. Their development is regulated by multiple signaling pathways. However, most ear diseases due to viral infections are due to congenital infections and reactivation, and affect healthy adults to a lesser extent. This may be due to the fact that viral infections affect signaling pathways that are important for the development of peripheral hearing organs. Therefore, an in-depth understanding of the relationship between viral infections and the signaling pathways involved in the development of peripheral hearing organs is important for the prevention and treatment of ear diseases. In this review, we summaries the effects of viruses on signaling pathways and signaling molecules in development of peripheral auditory organ, with a focus on Human cytomegalovirus as an example.
How Effective Were Isolation and Quarantine Strategies during the COVID-19 Pandemic: Challenges and Lessons Learned So Far?
Authors: Sivaraman Karthik , Dhawan Shubhra , Chopra Aditi , Bhat Subraya Giliyar
Published: June 2024

Isolation, quarantine, and contact tracing were some of the most critical and commonly employed non-pharmaceutical interventions to control the COVID-19 pandemic. However, the effectiveness of these strategies after their implementation depends upon many factors such as the country's population, availability of sufficient resources to diagnose and effectively isolate the infected individuals, and feasibility, and acceptability of isolation and quarantine policy by the public. This narrative review aims to appraise the current evidence on the correct implementation strategies and shortcomings made in the isolation and quarantine strategies during the COVID-19 pandemic. PubMed, SCOPUS, EMBASE, and Web of Science citation index with the following keywords were searched: Pandemic, COVID-19, Coronavirus, Quarantine, and Isolation. The results showed that quarantine and isolation of COVID-19 patients were more effective than late adoption (5-fold versus 2.6-fold)’. Around 90% of outbreaks could have been managed if 80% of contacts were monitored, traced, and isolated within 4 days. For each new case of COVID-19, around thirty-six individuals should have been traced. When the percentage of individuals without symptoms is greater than 30%, isolation and contact tracing alone cannot contain the infection. The delay between the onset of symptoms and isolation is the most important factor determining whether an outbreak is controllable. The ideal day for testing should start on the 6th of the quarantine. However, this evidence is mostly based on mathematical modeling studies, and evidence for its effectiveness in real scenarios is required. Symptom-based isolation strategy should not be considered the sole criterion for considering isolation.
Mixed Reality Navigation in Hip Fusion Conversion: A Novel Utilization of Advanced Technology
Authors: Leal Justin , Cullen Mark M. , Bolognesi Michael P. , Wellman Samuel S. , Ryan Sean P.
Published: June 2024

Case:

A 32-year-old woman with a history of hip fusion presented with significant lower back, hip, and knee pain as well as severely limited hip mobility and function. Single-stage fusion takedown and conversion to total hip arthroplasty (THA) was performed using augmented reality navigation. At 1 year, the patient was pain free with improved function. This study is the first to report the technique and outcomes of surgical fusion conversion to THA, using mixed reality navigation.

Conclusion:

Mixed reality navigation in complex conversion THA can be useful for identifying the patient's true acetabulum and for patient-specific acetabular component placement to maximize outcomes.
Analytic network process–based study of the importance and interconnectivity of facilities under volcanic ash risk
Authors: Kim Yoo Jung , Park Byung Cheol , Yoon Sanghoon , Lee Sungsu
Published: June 2024

In the event of a major volcanic eruption in the Korean Peninsula and other neighboring countries, there is a potential for widespread damage due to volcanic ash fallout, affecting various sectors across the country. Our study focuses on analyzing the importance and interconnectedness of different areas to develop effective volcanic ash risk assessment techniques and damage mitigation measures. We classified the areas susceptible to volcanic ash damage and analyzed the risks and interconnections of each sector using the analytic network process (ANP). We categorized the damage caused by volcanic ash into three major groups—human, facility, and industrial damage. Through a preliminary review, we identified 21 influence relationships among sectors affected by volcanic ash, which were incorporated into the ANP analysis. We designed an analytical network structure model to reflect the classification and correlation of damage areas, along with constructing a network syntax. Expert surveys were conducted to analyze importance and correlation using the SuperDecisions software. Transportation facilities, such as aviation, ships and ports, and infrastructure facilities, including electricity, broadcasting and telecommunications, were identified as high-risk areas. Hence, prioritizing these sectors in the development of volcanic ash risk assessment and mitigation technologies is crucial. In terms of interconnectivity, the electricity sector exhibited a ripple effect on all other areas. Medical facilities were particularly susceptible to influences from damage to roads, water supply, and electricity. The identification of volcanic ash risk facility sectors in this study is expected to contribute to establishing a comprehensive mid-to-long term strategy for volcano disaster prevention.
Locomotor profile of a new soccer modality played in 1v1 format
Authors: Fraga João Victor Cavalcanti , Barros Tércio Araújo do Rêgo , Lima Victor Ferreira , Filho Rostand Souza Lira , Silva Noadia Maria Guimarães da , Silva Marivânio José , China Tiago , Almeida Marcelus Brito , Fonseca Fabiano Souza , Santos Tony Meireles dos , Nakamura Fábio Yuzo , Henrique Rafael dos Santos
Published: June 2024

Purpose this study aimed to describe and compare the physical demands of emerging modality played in a 1v1 format of soccer, the X1, with matches lasting 20- and 30-min.Methods thirty-one professional X1 athletes participated in this investigation. Sixteen played in games lasting 20-min (height: 174.88 ± 8.24 cm; body mass: 72.17 ± 8.1 kg), while 15 played in matches lasting a total of 30 minutes (height: 175.83 ± 4.26 cm; body mass: 74.67 ± 6.1 kg). To carry out the study, GPS devices (K-50, K-Sports, Italy) were used. Main data analyzed included absolute and relative values of total distance, distance at different speed zones, number and distance at different accelerating and decelerating speeds.Results X1 players covered on average a total distance of 2240 ± 256.38 m and 3118 ± 441.99 m, for 20 and 30-min matches, respectively. The 30-min matches resulted in higher absolute values of all metrics analyzed, with effect sizes varying from 0.65 (sprinting distance) to 3.66 (walking distance). 20-min matches resulted in higher values of relative distance (78.25 ± 9.03 vs. 72.50 ± 6.54 m/min), relative jogging distance (17.25 ± 5.25 vs. 14.17 ± 3.03 m/min), relative accelerating and decelerating distance (2 m/s2 m/min).Conclusion the locomotor demands of athletes playing an 1v1 soccer match with different durations were very specific and singular due to the rules imposed for X1 athletes. In addition, 30-min matches played in this format elicits greater locomotor demands compared to 20-min, however, 20-min matches displayed higher relative demands in m/min.
Numerical simulation model for the curing of photosensitive acrylate resin in a stereolithography process
Authors: Blyweert Pauline , Nicolas Vincent , Fierro Vanessa , Celzard Alain
Published: June 2024

Controlling the precision and mechanical cohesion of 3D-printed parts remains a central concern in the development of additive manufacturing. A two-dimensional finite element model of the photopolymerization of a sensitive resin in a stereolithography apparatus is proposed as a tool for predicting and optimizing formulation and printing parameters. By considering light illumination, chemical reaction and heat transfer in a resin exposed to a moving UV laser source, this first approach accounts for monomer-to-polymer conversion and polymerization rate in agreement with experimental results obtained by FT-IR monitoring and the use of semi-empirical models. The temperature gradient along the exposed photosensitive material was also estimated. By varying the photoinitiator content and simulating the addition of an absorbing filler via the molar extinction coefficient, it was shown that a higher photoinitiator concentration and the presence of strongly absorbing fillers lead to a reduction in the light penetration depth, which can result in structural defects without adaptation of the layer thickness to be printed.
Commitment and professional ethics and its relationship with patient rights: A cross-sectional descriptive study
Authors: Mohammadnejad Sara , Raeesifar Afsaneh , Karamelahi Zoleikha , Chehreh Razhan
Published: June 2024

Background: Ethical behavior of health workers is an important part of health services. Providing ethical care is one of the important goals of various medical professions. the aim of the present study was to determine the relationship between ethics and professional commitment and its relationship with the level of respect for patient rights in medical students.
Material & methods: A cross-sectional descriptive study was conducted with the participation of nursing, midwifery and emergency medicine students of Ilam University of Medical Sciences. Sampling was done by stratified random method. The data was collected using Demographic, Professional Commitment, Professional ethics and a researcher made questioner on compliance with patient rights questionnaires.
Results: Three hundred students were participated. The results showed that the average score of professional ethics in middle school students is high (64.07 ± 8.01), the average score of professional commitment is also high (64.07 ± 8.01) and the score of respect for patient rights is also high (10.74). ± 83.46) was obtained. the professional ethics score it showed a positive and statistically significant relationship with the patient's rights compliance score.
Discussion: Its necessary to explain the concept of professional commitment to students more during the education period and to familiarize students with its dimensions and importance. It is necessary to study the relationship between these three variables with a larger sample size.
Polychlorinated Biphenyls' Impact on Comorbidity Networks: Unveiling Epidemiological Patterns and offsetting Through Dietary Adjustments
Authors: Gao Ying , Lu Han , Zhou Huan , Tan Jiaxing
Published: June 2024

Polychlorinated Biphenyls (PCBs), as a major class of organic pollutants, garnered increasing attention due to their significant ability for inter-regional accumulation and migration, prolonged half-life, and relatively high toxicity. Our study aimed to assess the impact of PCBs on various diseases and mortality risks using data from the National Health and Nutrition Examination Survey (NHANES), while proposing lifestyle adjustments, particularly dietary modifications, to mitigate mortality risk. Statistical analyses employed principal component analysis (PCA), multifactorial logistic regression, multifactorial Cox regression, comorbidity network analysis, and machine learning prediction models. Results indicated significant associations between 7 types of PCBs and 12 diseases (p < 0.05), with 6 diseases showing significant positive correlations (OR > 1, p < 0.05), along with listing the 25 most relevant diseases, such as asthma and chronic bronchitis (OR (95%CI) = 5.85(4.37,7.83), p<0.0001), arthritis and osteoporosis (OR (95%CI) = 6.27(5.23,7.55), p<0.0001). We proposed that PCB exposure ultimately triggered adverse progression of multiple diseases and increased mortality risk, suggesting PCBs could potentially serve as specific biomarkers for certain diseases in the future. Building upon this, we further suggested that controlling dietary intake to reduce dietary inflammatory index (DII) could lower mortality and disease risks. While PCBs were independent risk factors for mortality, ample evidence suggested that adjusting DII might mitigate the adverse effects of PCBs to some extent. Further physiological mechanisms require deeper exploration through additional research.
Research on the heat dissipation performances of vehicle power battery pack with liquid cooling system
Authors: Yin Deyou , Ni Jimin , Shi Xiuyong , Liu Hua
Published: June 2024

Lithium-ion power batteries have become integral to the advancement of new energy vehicles. However, their performance is notably compromised by excessive temperatures, a factor intricately linked to the batteries' electrochemical properties. To optimize lithium-ion battery pack performance, it is imperative to maintain temperatures within an appropriate range, achievable through an effective cooling system. This paper delves into the heat dissipation characteristics of lithium-ion battery packs under various parameters of liquid cooling systems, employing a synergistic analysis approach. The findings demonstrate that a liquid cooling system with an initial coolant temperature of 15℃ and a flow rate of 2L/min exhibits superior synergistic performance, effectively enhancing the cooling efficiency of the battery pack. As the charge/discharge rate increases, battery heating power escalates, resulting in a notable rise in temperature and synergy angle. Optimal cooling efficiency is achieved with three cooling channel inlets, minimizing the temperature difference across the battery pack.
Surface Polarization Profile of Ferroelectric Thin Films Probed by X-Ray Standing Waves and Photoelectron Spectroscopy
Authors: Mercurio Giuseppe , Hoang Le Phuong , Spasojevic Irena , Lee Tien-Lin , Pesquera David , Rossnagel Kai , Zegenhagen Jörg , Catalan Gustau , Vartaniants Ivan , Scherz Andreas
Published: June 2024

Understanding the mechanisms underlying a stable polarization at the surface of ferroelectric thin films is of particular importance both from a fundamental point of view and to achieve control of the surface polarization itself. In this study, we demonstrate that the X-ray standing wave technique allows the surface polarization profile of a ferroelectric thin film, as opposed to the average film polarity, to be probed directly. The X-ray standing wave technique provides, with picometer accuracy, Ti and Ba atomic positions near the surface of three differently strained BaTiO3 thin films. This technique gives direct access to the local ferroelectric polarization at and below the surface. By employing X-ray photoelectron spectroscopy, a detailed overview of the oxygen-containing species adsorbed on the surface is obtained. The different amplitude and orientation of the local ferroelectric polarizations are associated with surface charges attributed to different type, amount and spatial distribution of the oxygen-containing adsorbates.
Comunicar historias. El rol de la intervención para el desarrollo de habilidades narrativas
Authors: Vivas-Rodríguez Marta E.
Published: June 2024

La presente investigación tiene por objetivo analizar el rol de la intervención para el desarrollo comunicativo del discurso narrativo, tanto para niños y niñas con desarrollo típico como para aquellos con Trastorno del Lenguaje (TDL). La revisión bibliográfica, el análisis cualitativo y la investigación hermenéutica son las bases metodológicas seguidas. Para su desarrollo se ha seguido el método PRISMA, configurado como un instrumento para la confección de revisiones sistemáticas, de tal forma que los investigadores puedan certificar estudios inteligibles y eficaces para la toma de decisiones. Los resultados se han sistematizado atendiendo a cuatro pautas: las investigaciones para el discurso narrativo en el desarrollo típico, aquellas otras para los niños con TDL, los estudios relevantes para el análisis de la importancia de la intervención y, por último, y sustancial, los Programas de Intervención en Habilidades Narrativas. Se presentan dos programas específicos: Story Champs y EDEN, los cuales abordan aspectos claves del discurso narrativo, tales como la estructura de la historia, el uso de vocabulario apropiado y la coherencia global. Se concluye incidiéndose en la importancia de saber comunicar historias para el desarrollo de habilidades narrativas.
Identification of Vascular Genes Differentially Expressed in the Brain of Patients with Alzheimer's Disease
Authors: Jara-Medina Kevins , Lillo Luis , Lagunas Constanza , Cabello-Guzmán Gerardo , Valenzuela-Melgarejo Francisco J.
Published: June 2024

Background:

Alzheimer's disease (AD) plays a prominent role as the most common
form of dementia. Moreover, the traditional mechanism of AD does not explain the microvascular
damage observed in about 25-30 years between the onset of AD, which results in late application
treatment that inhibits or delays neurodegeneration.

Objective:

Our objective was to identify differentially expressed genes in human brain samples associated
with vascular disruption in AD.

Methods:

We analyzed 1633 post-mortem brain samples in the GEO database and, after applying
clinical and bioinformatic exclusion criteria, worked with 581 prefrontal and frontal samples. All
datasets were analyzed using GEO2R from NCBI. We identified common genes using the Venny
tool, and their metabolic relevance associated with AD and the vascular system was analyzed using
MetaboAnalyst tools.

Results:

Our bioinformatic analysis identified PRKCB, MAP2K2, ADCY1, GNA11, GNAQ,
PRKACB, KCNMB4, CALD1, and GNAS as potentially involved in AD pathogenesis. These
genes are associated with signal transductions, cell death signaling, and cytoskeleton, suggesting
potential modulation of cellular physiology, including endoplasmic reticulum and mitochondrial
activity.

Conclusion:

This study generates hypotheses regarding the roles of novel genes over critical pathways
relevant to AD and its relation with vascular dysfunction. These findings suggest potential
new targets for further investigation into the pathogenesis of dementia and AD.
Enteral Feeding Dilemmas: Navigating the Impact of Bacterial Contamination in Hospitalized Populations
Authors: Fatemizadeh Somayeh , Mahboobi Hamidreza , Moghtadaie Atie , Sarmadian Amirreza Jabbaripour , Kamal Mohammad Amjad
Published: June 2024

Introduction:

Enteral feeding is essential for hospitalized patients unable to consume
oral nutrition. However, it poses a risk of bacterial contamination, leading to infections and increased
morbidity and mortality.

Methods:

Studies have shown that contaminated enteral feeds are associated with longer hospital
stays and worsened patient outcomes. Common pathogens include Gram-negative bacilli (e.g., Serratia
spp., Klebsiella spp., Enterobacter spp.), coagulase-negative staphylococci, and Clostridium
difficile. Preventing contamination requires identifying and mitigating potential routes. This comprehensive
approach encompasses careful practices during production, storage, preparation, and
administration of enteral feeds.

Results:

Early initiation of enteral feeding has also been linked to lower infection rates. Standardized
protocols, hand hygiene adherence, routine monitoring for infection signs, and ongoing
staff education are crucial for safe enteral feeding. Further research is needed to better understand
risk factors for contamination and evaluate the effectiveness of preventive interventions.

Conclusion:

Addressing these knowledge gaps can significantly improve the quality of enteral
feeding and reduce infection burden in hospitalized patients.
Design and Performance Analysis of A Linear Switched Reluctance Motor Considering End Effects
Authors: Lachheb Aymen , Salem Jamel Ben , Amraoui Lilia El
Published: June 2024

Introduction:

In recent years, linear actuators have gained significant attention due to
their ability to provide direct linear movement without the need for motion transformation devices.
One significant challenge in the design and modeling of linear actuators is the occurrence of longitudinal
end-effects. The finite length of the translator stack in linear actuators causes an unbalanced
phase force, leading to discrepancies between the phases at the end and center of the actuator. Neglecting
these end-effects can lead to inaccuracies in the actuator's performance and control.

Methods:

The objective of this study is to develop a comprehensive approach for the design, sizing,
and modeling of the actuator to ensure optimal performance. An energy conversion procedure
calculates the thrust force and determines the actuator's geometrical parameters. A numerical
model based on the finite element method is developed to analyze the actuator's magnetic behavior
and establish its characteristics. Furthermore, a thorough analysis of the end effect is conducted
using two-dimensional finite element analysis.

Results:

To accurately capture the actuator's dynamic response and enable precise control, a mathematical
model is formulated, incorporating the nonlinear behavior of inductance and incorporating
the end effect factor. The proposed model demonstrates high accuracy and provides a solid
foundation for the control of the linear switched reluctance actuator.

Conclusion:

Overall, this study contributes to the advancement of direct drive systems for industrial
applications by providing a detailed design procedure and an accurate modeling approach for
the linear actuator, enabling more efficient and precise control strategies.
Segal, L. (2014). Out of time: The pleasures and perils of ageing. London: Verso Books. Review by Carla Besora Barti
Authors: Barti Carla Besora
Published: June 2024

What first drew me to read Lynne Segal’s book Out of Time (2014) was its subtitle, ‘The Pleasures and Perils of Ageing.’ I have embarked on a research project on ageing, women, and sexuality, and in reviewing the existing literature on the subject, I realized that much more attention is paid to the ‘perils’ than the ‘pleasures’ of ageing. Lynne Segal deals with both in her book, by combining analyses of narratives about ageing in literary fiction and the media with her own experience as a woman growing older. She examines the words and lives of poets, writers, and artists—mostly from the Anglophone world—to find out what it means to grow older in an ageist society.
Fraiman, S. (2017). Extreme Domesticity: A View from the Margins. New York: Columbia University Press. Review by Yishi Pan
Authors: Pan Yishi
Published: June 2024

In her essay Professions for Women (1931), Virginia Woolf shares her ambition to kill ‘the Angel in the House,’ Coventry Patmore’s now infamous image of idealised nineteenth-century femininity. Serving as a symbol of purity and selflessness in the Victorian era, the Angel ‘never had a mind or a wish of her own’ but preferred to sacrifice herself for the well-being of domestic life (p. 141). Woolf thus calls for resistance against the Angel, whose haunting shadow always lurks around, waiting to deprive women of their own voice. In Extreme Domesticity (2017), Fraiman likewise denounces this iconic image when she begins a discussion on the relation between women and domesticity.
Tsing, A. (2015). The Mushroom at the End of the World: On the Possibility of Life in Capitalist Ruins. Princeton: Princeton University Press. Review by Sarah Postema-Toews
Authors: Postema-Toews Sarah
Published: June 2024

Anna Lowenhaupt Tsing opens her book by discussing the enlightenment paradigm that relegated nature as passive background and resources for humans to extract and profit from. She states that previously it was mainly non-western storytellers who explored the realm of interconnection between all beings, human and non-human alike. This notion of ‘interspecies entanglement’ has become a growing topic within contemporary biological research thus destabilising modernist assumptions that place humans at the forefront of knowledge and perceived value (Tsing, 2015, p. vii).
Preventing Cognitive Decline in Older Latino Adults With HIV Through a Culturally Tailored Health Promotion Intervention: Protocol for a Single-Arm Pilot Trial
Authors: Jimenez Daniel E , Ross Emily J , Weinstein Elliott , Gouse Hetta , Pan Yue , Martinez Garza David , Burke Shanna L , Joo Jin Hui , Behar-Zusman Victoria
Published: June 2024

Background

Older Latino adults with HIV are at increased risk for mild cognitive impairment and earlier onset of aging-related cognitive decline. Improvements in cognitive functioning and cognitive outcomes are possible among people with HIV who adopt health promotion behaviors. However, health promotion interventions for older Latino adults with HIV have not been extensively used or widely recognized as viable treatment options. Happy Older Latinos are Active (HOLA) is a multicomponent, health promotion intervention that is uniquely tailored for older Latino adults with HIV.

Objective

This study aims to (1) determine the feasibility and acceptability of an adapted version of HOLA aimed at improving cognitive functioning among older Latino adults with HIV; (2) explore whether HOLA will produce changes in cognitive functioning; (3) explore whether HOLA will produce changes in activity, psychosocial functioning, or biomarkers of cognition; and (4) explore whether changes in activity, psychosocial functioning or cognitive biomarkers correlate with changes in cognition, while accounting for genetic risk for dementia.

Methods

A single-arm pilot trial with 30 Latino (aged 50 years and older) men and women with HIV was conducted to assess feasibility, acceptability, and preliminary effects on cognition. Participants were assessed at 2 time points (baseline and postintervention) on measures of neurocognitive and psychosocial functioning. In addition, blood samples were collected to determine biomarkers of cognition at baseline and postintervention. Successful recruitment was defined as meeting 100% of the targeted sample (N=30), with 20% (n=6) or less of eligible participants refusing to participate. Adequate retention was defined as 85% (n=25) or more of participants completing the postintervention assessment and acceptability was defined as 80% (n=38) or more of sessions attended by participants.

Results

Participant recruitment began on February 22, 2022, and was completed on August 15, 2022. The last study visit took place on February 20, 2023. Data analysis is currently ongoing.

Conclusions

Encouraging findings from this exploratory study may provide a blueprint for scaling up the HOLA intervention to a larger cohort of older Latino adults with HIV who may be currently experiencing or are at risk for HIV-related cognitive challenges.

Trial Registration

ClinicalTrials.gov NCT04791709; https://clinicaltrials.gov/study/NCT04791709

International Registered Report Identifier (IRRID)

DERR1-10.2196/55507
The safety of digital mental health interventions: Findings and recommendations from a qualitative study exploring users’ experiences, concerns, and suggestions (Preprint)
Authors: Taher Rayan , Stahl Daniel , Shergill Sukhi , Yiend Jenny
Published: June 2024

BACKGROUND

The literature around the safety of digital mental health interventions is growing. However, the user/patient perspective is still absent from it. Understanding the user/patient perspective can ensure that professionals address issues that are significant to users/patients and help direct future research in the field.

OBJECTIVE

This qualitative study aims to explore digital mental health interventions’ users’ experiences, views, concerns, and suggestions regarding the safety of digital mental health interventions.

METHODS

The inclusion and exclusion criteria were 18 years old or above, has previous experience using a digital mental health intervention (DMHI) and can speak and understand English without the need for a translator. Fifteen individual interviews were conducted. Deductive thematic analysis was used to analyze the data.

RESULTS

The analysis of the interview transcripts yielded four main themes: Safety Concerns: users’ concerns around the safety of DMHIs, Safety Assessment: assessing a DMHI’s safety from users’ perspectives, Experienced Risks: the risks experienced by DMHIs’ users, Experienced Mitigations: the risk mitigation methods experienced by DMHIs’ users, and Mitigation Suggestions: users' suggestions on how risks can be mitigated.

CONCLUSIONS

The results of this study led to seven recommendations on how the safety of digital mental health interventions can be improved. These recommendations arose from users' experiences and suggestions. If implemented, these recommendations can improve the safety of digital mental health interventions and enhance users’ experience.
Towards Sustainable Management of Parkinson’s Disease Healthcare: Evaluating the Role and Impact of Mobile Health Devices (Preprint)
Authors: Memedi Mevludin , Emruli Blerim , Cao Yang , Hedström Karin
Published: June 2024

BACKGROUND

Mobile health devices (MHDs), such as wearables and smartphones, have the potential to improve the monitoring of people with Parkinson’s disease (PD) and inform timely and individualized disease management decisions.

OBJECTIVE

This paper provides an overview of the technologies behind mobile health devices MHDs and investigate their potential for sustainable management of PD.

METHODS

A literature search using PubMed, Scopus, and IEEE Xplore was performed between October 30, 2023, and November 16, 2023, for studies investigating the use of MHDs to measure PD cardinal motor features.

RESULTS

A total of 138 relevant papers drawn from 2364 papers were analyzed. MHDs have been mainly used to assess gait and bradykinesia (slowness of movements). Most studies focused on the patient outcomes, while overlooking aspects such as the integration of MHDs in healthcare workflows and sustainable viability factors (user adoption and cost-effectiveness).

CONCLUSIONS

When designing MHD-based interventions it is essential to balance the focus on immediate health benefits for PD patients with equal consideration for technology integration, cost-effectiveness, and user adoption to ensure comprehensive, impactful, and sustainable contributions of such interventions.