bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloning and secretory expression of functional diisopropyl-fluorophosphatase (DFPase) in Bacillus subtilis
Authors: Ahmadizad Firouzjaei Ali , Abolmaali Shamsozzoha , Khodi Samaneh , Aghamollaei Hossein , Latifi Ali Mohammad , Mirzaei Morteza
Published: July 2021

Background and aims: Synthetic organophosphates (OPs) inhibit acetylcholinesterase resulting in the accumulation of acetylcholine, failure of organs, and eventually death. Diisopropyl-fluorophosphatase (DFPase) is one of the OPs degrading enzymes that has broad substrate from OPs. In this study, for the first time, the secretory expression of DFPase in Bacillus subtilis was investigated in order to accelerate the biodegradation rate of OPs. Methods: DFPase gene was amplified using polymerase chain reaction (PCR) from the pET28-inaV/N-dfpase plasmid. The PCR product was subcloned in the pWB980 plasmid. Competent B. subtilis WB600 were transformed with recombinant plasmid. SDS PAGE technique was used to study the expression of protein secreted in superrich medium. Results: Appearance of the 946 bp band in agarose gel after digestion of transformed plasmid confirmed the presence of DFPase gene in this construct. Approximately, 35 kDa protein band was shown in culture medium after incubating at 35°C for 72 hours and 150 rpm. Measurement of enzyme’s activity was done by monitoring the release of fluoride from diisopropyl fluorophosphate (DFP), using ion-meter. Results showed that enzyme’s activity was 3333 U/L. Conclusion: Bacillus subtilis is a suitable host for production of secretory and active form of DFPase.
The antinociceptive effects of folic acid using formalin and acetic acid tests in male mice
Authors: Hajiallilo Morteza , Abbasi-Maleki Saeid
Published: July 2021

Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This study aimed to investigate the potential antinociceptive effects of FA using formalin and acetic acid tests in male mice. Methods: Sixty male albino mice (20-30 g) were randomly divided into 10 groups (n=6 in each group) of negative control, positive control (morphine or indomethacin), and FA (10, 15, and 30 mg/kg) groups. In the formalin test, duration of paw licking and biting the right hind paw during acute (0-5 minutes) and chronic (15-60 minutes) pain after intraplantar injection of formalin 2.5% (25 µL) was recorded. In the writhing test, the abdominal constrictions were recorded after the intraperitoneal injection of acetic acid 1%. Results: Only a high dose (30 mg/kg) of FA significantly reduced acute pain (P=0.001) compared with the control group. But all doses of FA significantly decreased chronic pain (P=0.001). In addition, morphine significantly reduced both phases of pain (P=0.020 and P=0.001, respectively). Moreover, indomethacin and all doses of FA decreased the number of abdominal constrictions induced by acetic acid (P=0.001). Conclusion: Compared with acute (neurogenic) pain, FA more potently decreases chronic (inflammatory) pain. Furthermore, FA decreases the parietal pain that could potentially represent antinociceptive effect. However, further studies are needed to elucidate the exact mechanism of FA’s analgesic activity.
Evaluating Pancreatic index in Patients with and without Metabolic Syndrome
Authors: Mohammadmirzaei Zahra , Farahmand Habib , Ahmadi Jafar , Rezvan Sajad , Noori Enayatollah , Hormati Ahmad
Published: July 2021

BACKGROUND Metabolic syndrome can be considered as a combination of metabolic disorders that may led to an increased risk of some diseases such type II diabetes, cardiovascular diseases, myocardial infarction, and is the cause of mortality from coronary artery disease. Its prevalence is particularly high in women. There is evidence that pancreatic fat, as a key factor in non-alcoholic fatty liver and metabolic syndrome, numerates as an early indicator of abnormal fat deposition. METHODS In this study, we enrolled 262 patients, who were admitted to Ali Ibn Abi Talib Hospital in Rafsanjan city, using the non-random-sequential method. Data collection tools were a questionnaire containing demographic characteristics (age, sex, history of diseases, etc.) and a checklist including MetS (based on NCEP/ATP III criteria and Diabetes Committee), pancreatic density (P), and spleen (S) and pancreatic index (P/S). One-way ANOVA and Post-Hoc and Chi-square tests were used for statically analyses. RESULTS The prevalence of metabolic syndrome was 34.8%, index of pancreas in the group without and with metabolic syndrome were 0.85 ± 0.11 and 0.74 ± 0.29 Hounsfield Units, respectively. CONCLUSION Compared with the group with at least one criterion and the group with the complete criteria (p = 0.013), pancreas index was higher in the group without metabolic syndrome.
Melatonin Levels in Patients with Nonalcoholic Fatty Liver Disease Compared with Healthy Individuals according to Fibrosis Level
Authors: Sohrabi Masoudreza , Gholami Ali , Taheri Mahsa , Fekri Sina , Amirkalali Bahare , Hatami Sare , Hajbaba Marzieh , Fallah Tolbar Hamid , Aghili Sheida , Zamani Farhad , NasiriToosi Mohsen , Keyvani Hossein
Published: July 2021

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide. Studies have shown that melatonin, as a regulatory hormone, is effective in different cell protective pathways. We aimed to compare serum melatonin levels of patients with NAFLD with different stages of fibrosis with that of healthy individuals. METHODS In this cross-sectional study patients, aged >20 years with elevated serum liver enzymes and trance abdominal sonographic diagnosis of fatty liver who met the exclusion criteria for NAFLD were included. The participants were categorized into three groups as follows: 1) severe fibrosis (fibrosis > 9.1 kPa and steatosis > 285 dbm), 2) mild-moderate fibrosis (fibrosis: 6-9.0 kPa and steatosis 240-285), and 3) normal group with fibrosis < 5.8 kPa and steatosis < 240 dbm based on Fibroscan evaluation. Five ml of fasting venous blood was taken from each patient and the control group for laboratory assessment. A questionnaire including demographic, anthropometric, laboratories (serum ALT, AST, triglyceride, total cholesterol and melatonin level), and clinical data was completed for all participants. RESULTS 97 people with a mean±SD age of 42.21 ± 11 years were enrolled. 59 (60.0%) patients were women. we observed that the melatonin levels were increased by advancing fibrosis. Based on control- attenuated parameter results the melatonin levels significantly differed between the healthy individuals and patients with severe steatosis. There was a direct association between increased melatonin levels and liver enzymes. CONCLUSION As a regulatory hormone, melatonin may directly be associated with liver cell injuries. Therefore, considered regulatory substances such as melatonin either diagnostic or therapeutic can improve the patients’ outcome.
Diagnostic Significance of Serum Fatty Acid Synthase in Patients with Pancreatic Cancer
Authors: Fazli Hamid Reza , Moradzadeh Maliheh , Mehrbakhsh Zahra , Sharafkhah Maryam , Masoudi Sahar , Pourshams Akram , Mohamadkhani Ashraf
Published: July 2021

BACKGROUND Pancreatic cancer is considered as the most deadly tumor among gastrointestinal cancers because of its poor prognosis. The frequently deregulated pathway in the cancer cell is associated with an increased expression of various genes, including the synthesis of fatty acids. We aimed to evaluate the level of serum fatty acid synthase (FASN) as a diagnostic marker for early diagnosis of pancreatic cancer. METHODS Serum FASN levels were measured by ELISA in 92 patients with pancreatic adenocarcinomas and in 92 healthy controls. Logistic regression analysis was used to identify independent predictors of certain diagnostic categories. RESULTS Serum FASN levels were significantly higher in patients with pancreatic cancer than in healthy controls (1.35 [0.98-2.3] ng/mL vs 1.04 [0.19-1.34] ng/mL, p < 0.001) and in smokers compared to non-smokers (1.41 [0.79-2.52] ng/mL vs 1.07 [0.21-1.74] ng/mL, p < 0.001). FASN levels and smoking were associated with increased risk of PC (1.54 [1.1- 2.14] ng/mL, p = 0.011 and 5.69 [2.68-12.09] ng/mL, p < 0.001, respectively). CONCLUSION Elevated serum FASN levels in patients with pancreatic cancer indicate the need for the production of large numbers of lipids for the survival and proliferation of human cancer cells and the diagnostic value of FASN as a new diagnostic biomarker.
Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study
Authors: Niknam Ramin , Salehi Alireza , Molavi Vardanjani Hossein , Fattahi Mohammad Reza , Dehghani Seyed-Mohsen , Honar Nasser , Haghighat Mahmood , Imanieh Mohammad-Hadi
Published: July 2021

BACKGROUND Celiac disease is a common disorder but there are few studies comparing the clinical features of the disease in adults, adolescents and children. METHODS Demographic and clinical characteristics of all patients with celiac disease referred to the Celiac Clinic were evaluated and compared in different age groups. RESULTS Of 3416 participants, 473 patients were included. 302 (63.8%) were women and 171 (36.2%) were men. Overall, 325 (68.7%) and 411 (86.9%) patients had gastrointestinal (GI) and non-GI manifestations, respectively. The most common symptom in adults was psychiatric problems (66.5%), while abdominal discomfort was the most common symptom in adolescents (45.2%) and children (53.8%). According to age groups, GI manifestations were seen in 79 (66.4%), 119 (59.8%), and 127 (81.9%) children, adolescents, and adults, respectively. Adults had significantly more GI manifestations than the other groups (PR 1.167; 95% CI: 1.094- 1.244; p < 0.001). Non-GI manifestations were seen in 90 (75.6%), 174 (87.4%), and 147 (94.8%) children, adolescents, and adults, respectively. Adults had significantly more non-GI manifestations than the other groups (PR 1.112; 95% CI: 1.060-1.168; p < 0.001). CONCLUSION Our study showed that there were significant differences in the clinical features of celiac disease between the different age groups. Considering these results may help plan for future studies.
Association between Sleep Quality and Gastroesophageal Reflux in Medical Students
Authors: Teimouri Azam , Amra Babak
Published: July 2021

BACKGROUND Due to stressful occupational conditions, irregular dietary and sleep schedules, medical students are at increased risk of developing gastrointestinal disorders, gastroesophageal reflux (GERD) in particular, as well as sleep disturbances. Therefore, for the first time, we aimed to assess the correlation between GERD and sleep disturbances among medical students. METHODS The current cross-sectional study was done on 290 medical students at different study periods in Iran during 2018-2019. Age, sex, stage of studying, residence, and body mass index were gathered. The frequency scale for the symptoms of gastroesophageal reflux (FSSG) was utilized to assess gastrointestinal symptoms among them and the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality. Eventually, the association of sleep disturbances with demographic factors and gastrointestinal symptoms was evaluated. RESULTS Living in the dormitory (p = 0.048; OR: 1.73; 95%CI: 1.01-2.99) and being overweight (p < 0.001; OR: 3.09; 95%CI: 1.58-6.06) were independently correlated with impaired sleep quality. GERD presented either by heartburn (p < 0.001) or regurgitation (p < 0.001) was associated with a lower quality of life. CONCLUSION GERD was correlated with poor sleep quality among medical students. In addition, residence in dormitory and being overweight were correlated with poor sleep quality.
Development of Inflammatory Bowel Diseases Registry Software
Authors: Keikavousi Mohammad Reza , Asadi Farkhondeh , Paydar Somayeh , Khounraz Fariba
Published: July 2021

BACKGROUND With an increase in the prevalence and incidence of inflammatory bowel diseases (IBDs), they have become a global challenge. The IBD registry provides complete and timely data, thereby greatly contributing to the estimation of the burden of these diseases and development of control and prevention programs. We aimed to develop an IBD registry software. METHODS The present applied-developmental study had two main stages: determining user requirements, and developing the IBD registry software. The software was created using a Web-based software development technology called ASP.NET Core 2. The programming language in this framework was #C, and the SQL Server 2017 was employed to create a strong and integrated software databank in the relational form. RESULTS When determining user requirements, the data elements were classified into two main categories of patient information and visits and tests. Moreover, in this stage, registry functions, including case ascertainment, abstracting, follow-up, quality control, and reporting were identified. In the registry software development stage, the object-oriented conceptual model was designed with five use case diagrams and 59 classes. The user interface comprised the following main sections: add patient, find patient, complete source report, report, staff, and drugs. Precise user authentication and authorization were also employed to enhance the security of the developed software. CONCLUSION Development of an IBD registry which can precisely record patients and estimate the incidence, prevalence, and socioeconomic burden of these diseases can assist in planning for the control and prevention of IBD in healthcare systems.
Blue Rubber Bleb Nevus Syndrome because of 12 Years of Iron Deficiency Anemia in a Patient by Double Balloon Enteroscopy; A Case Report and Review of Literature
Authors: Dooghaie Moghadam Arash , Bagheri Mohammad , Eslami Pegah , Farokhi Ermia , Nezami Asl Amir , Khavaran Karim , Iravani Shahrokh , Saeedi Sandra , Mehrvar Azim , Dooghaie-Moghadam Masoud
Published: July 2021

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder comprised of venous malformation mostly involving the skin and gastrointestinal (GI) tract but can also involve other visceral organs. The most predominant site of GI tract involvement is the small bowel. In patients with GI lesions, treatment depends on the severity of bleeding, and extent of involvement. Conservative therapy with iron supplementation and blood transfusion is appropriate in cases with mild bleeding but in severe cases endoscopic and surgical interventions would be beneficial. Also, medical therapy with sirolimus significantly reduces bleeding. A 20-year-old woman was referred to our hospital after transfusion of six units of packed cell because of several episodes of lower GI bleeding within the past three months in the form of melena and a single episode of hematochezia. Her last hemoglobin level before admission was 10mg/dl. She underwent various unsuccessful investigations since she was eight years old to find the origin of refractory iron deficiency anemia. In upper endoscopy, five bleeding polypoid lesions were discovered in the jejunum. Lesions were excised by snare polypectomy. Over a six-month follow-up period, no signs of lower GI bleeding were noted and the patient had a normal hemoglobin level.
Extrapulmonary Sarcoidosis Manifested as Cirrhosis with Portal Hypertension
Authors: Kothakota Sunil Raviraj , Kumar Nair Ajith , Sasidharan Madhu , Kareem Harish , Praveen Kumar C , Kanala Jagadeswarareddy
Published: July 2021

Hepatic involvement has been reported in 20-30% of patients with systemic sarcoidosis. However, isolated liver involvement is rare. We report a case of cirrhosis with portal hypertension, diagnosed as hepatic sarcoidosis based on high angiotensin-converting enzyme level and presence of multiple non-caseating granulomas in liver histopathology. She improved clinically after treatment with steroid and ursodeoxycholic acid.
Frequency and Clinical Presentations of Laryngeal Polyps
Authors: Gasembaglou Shahram , Shahidi Nikzad
Published: July 2021

Background: Since the Laryngeal polyp counts as one of the most prevalent laryngeal disorders which could burden the individual and society and lack of evidence with regard to its risk factors especially in Iran present study was carried out to determine Frequency and clinical presentations of laryngeal polyps. Methods: In this cross-sectional analytic study, 150 patients diagnosed with laryngeal polyps who sought care at Emam Reza hospital of Tabriz from 1390 to 1396 were included. Collected data consisted of Age, Gender, Occupation, Living area, chief complaint, History of other diseases, history of vocal abuse, history of polyp in first degree relatives and habit history of patients. Results: Majority of participants (84.7%) were male. Thirty percent of Laryngeal polyp were in fifth decade of life. Only 30 percent of individuals declared a history of vocal abuse at some point. Hoarseness was the main complaint and one-third of patients mentioned a history of GERD. One -third of them consumed cigarettes. Conclusion: Male Gender could increase the risk of developing laryngeal polyp. Age of 40-60 years and living in an urban setting could as well considered as a risk factor.
Association between DRD4 rs1800955 polymorphism and Attention Deficit Hyperactivity Disorder susceptibility among children from Northwest of Iran: a case-control study
Authors: Khalilinejad Nava , Mehdizadeh Fanid Leila , Zeinalzadeh Narges , Alizadeh Maedeh
Published: July 2021

Background: Attention deficit hyperactivity disorder (ADHD) is the most common and highly heritable psychiatric disorder among children which affects 3-7% of them all around the world. ADHD characterized by some symptoms such as extreme and inappropriate levels of motor activity, impulsivity and inattentiveness. Several studies have reported the association between dopaminergic pathway and ADHD. Dopamine D4 receptor gene and its variants is one of the major candidates that have been studied for ADHD. Here we investigated the genetic association between DRD4 rs1800955 polymorphism and ADHD among children from Northwest of Iran. Methods: This case-control study includes 200 ADHD children and 157 controls aged 6-12 years. ADHD children were diagnosed according to DSM-IV and Conners scale and were genotyped by PCR-Restriction fragment length polymorphism (RFLP) technique. Results: Frequencies of genotypes CC, TT and CT were 48 (24%), 15 (7.5%) and 137 (68.5%) in patient group and 50 (31.85% %), 7 (4.46%) and 100 (63.69 %) in control group respectively. According to results, there was no significant association between case and control groups (p>0.05). Conclusion: The results of this study indicate that there is no significant association between DRD4 rs1800955 polymorphism and attention deficit hyperactivity disorder among children from Northwest of Iran.
Effect of one-week supplementation of Citrulline-malate, L-arginine and their combination on CK, LDH and CRP levels in male wrestlers following simulated wrestling test
Authors: Shakib Amir , Amir sasan Ramin , Vakili Javad
Published: July 2021

Background: The aim of this research was to evaluate the effect of one-week supplementation of citrulline-malate, L-arginine and their combination on aerobic and anaerobic powers, CK, LDH and CRP levels in male wrestlers. Methods: In this experimental study, 40 male wrestlers (aged 19-25 years; weight 60-90 kg; body fat percent 12-20%) in a randomized and double-blind design were divided in four equal citrulline-malate (Cit; 4g/days), L-arginine (Arg; 4g/days), their combination (2g/days Arg + 2g/days Cit) and placebo (dextrose; P) group. Before and after supplementation one week period, all subjects were participated in a competition like wrestling. Each test consisted of two 3 min periods of arm-cranking at maximal executable cadence against resistance of 0.1 kg ∙ kg−1 body mass interspersed with 30-s recovery periods between consecutive tests. Blood samples were obtained in the 4 phases: one hour before and 5 min after two competitions like wrestling protocols. Creatine kinase (CK), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were analyzed. Change any of the parameters (mean and standard deviation) of four stages repeated ANOVA and post hoc tests. The significance level was set at p<0.05. Results: Based on the present results, the Cit and Arg + Cit supplementation attenuated the exercise-induced increase in response of CK (p<0.05). However, the Arg supplementation had not any significant effect on the exercise-induced increase response of serum CK. Also, the Arg, Cit and Arg + Cit supplementation had not any significant effect on the exercise-induced increase response of total serum LDH and CRP. Conclusion: Based on the present results, it can be concluded that the one week citrulline-malate with L-arginine supplementation is more effective than the citrulline-malate or L-arginine supplementation to overcome the exercise-induced adverse responses in some muscle injury parameters. Therefore, combination of citrulline-malate and L-arginine supplementation is recommended to reduce exercise-induced adverse consequences.
The effect of Progressive Resistance Training and High Intensity Interval Training on TRAF6 gene expression of the heart muscle and serum TNF-α levels in male diabetic rats
Authors: Tonkaboni Seyedeh Fatemeh , Khaledi Neda , Askari Hossein
Published: July 2021

Background: The most common causes of mortality in diabetic patients are cardiovascular disorders, one of the reasons being inflammatory factors. Given that physical activity can reduce inflammation, the present study was to investigate the effects of two types of Progressive Resistance Training (RT) and High Intensity Interval (HIIT) on the expression of TRAF6 gene and serum levels of TNF-α in male diabetic rats. Methods: In this experimental study, 72 male rats were divided into 6 groups of 12 diabetic rats (n=12), control (n=12), diabetic High Intensity Interval Training (n=12), High Intensity Interval Training(n=12), diabetic Progressive Resistance Training(n=12) and Progressive Resistance Training(n=12). Progressive Resistance Training was performed in a 6-weekly 3-session, climbing the vertical ladder, with 50%, 75%, 90% and 100% the body weight of the animals. After successful completion, 30 gr were added to the weights, to the extent that the rats cannot carry the ladder. High Intensity Interval Training were also performed at 6-weekly 3-session, with an intensity of 50 to 110% of the VO2max. 24 hours after the completion of the training, the functional test was taken and the animals were autopsy 48 hours after the test. Finally, the expression of TRAF6 gene was evaluated using Real Time PCR and serum TNF-α level by ELISA method. Results: TRAF6 levels increased significantly after the two Training in the diabetic group, which was higher in the HIIT group and serum TNF-α levels decreased significantly after both types of training, which was more prominent in the HIIT group. Conclusion: HIIT and RT can play an important role in reducing the inflammatory factor of TNF-α in diabetic patient that HIIT is more effective in this regard. Increasing the gene expression of the mediating agent TRAF6 can be induced in inflammatory pathways, which may require a reduction in exercise intensity or in anti-inflammatory routes indicating a positive effect of training on diabetes.
Uso da krigagem indicatriz na avaliação de regiões para produção de feijão-caupi no estado da Bahia / Indicator kriging in the evaluation of regions for the production of bean/cowpea in the state of Bahia
Authors: González Guido Gustavo Humada , Liska Gilberto Rodrigues , Humada Belén Gaete
Published: July 2021

O feijão-caupi constitui-se em um dos principais componentes da dieta alimentar nas regiões Nordeste e Norte do Brasil. A deficiência de água é um dos fatores mais limitantes para a obtenção de elevadas produtividades; portanto, recomenda-se sua implantação em regiões com índices de precipitação que satisfaçam as necessidades da cultura. Objetivou-se analisar a estrutura da dependência espacial de dados de precipitação pluvial anual no estado da Bahia e a construção do mapa de probabilidade utilizando-se a técnica de krigagem indicadora com vista na localização de regiões de risco com altas e baixas probabilidades de precipitação inferiores a 500 mm. Os dados em estudo referem-se às informações de precipitação pluvial anual coletadas no ano 2014 no estado de Bahia; foram ajustados e comparados os modelos Gaussiano, exponencial e esférico. Os resultados mostram que o modelo Gaussiano se ajusta melhor aos dados, os quais apresentam dependência espacial forte, A técnica de krigagem indicadora mostra-se eficiente no mapeamento da probabilidade de precipitação em relação ao valor de corte estabelecido. Não é recomendado produzir feijão-caupi na região nordeste e no centro norte do estado da Bahia.
Primeiro registro de ocorrência e características biológicas de cação bruxa - Notorynchus cepedianus (Péron, 1807) no litoral Sul de Peruíbe - São Paulo – Brasil, nas Unidades de Conservação do Mosaico Juréia Itatins - APACIP (Área de Proteção Ambiental Cananéia-Iguape-Peruíbe) / First occurrence record and biological characteristics of broadnose sevengill shark – Notorynchus cepedianus (Peron, 1807) in South Coast of Peruíbe – São Paulo – Brazil, in the Juréia Itatins Mosaic Conservation Units – APACIP (Cananéia-Iguape-Peruíbe Environmental Protection Area)
Authors: Lopes Edris Queiroz , Martins Isabela , Miquelin Guilherme , De Melo Luana Félix
Published: July 2021

O Notorynchus cepedianus pertencente à família Hexanchidae (cação-sete-guelras), é uma espécie de rara ocorrência e está distribuído nas zonas tropicais a temperadas dos três oceanos, comumente encontrado em águas costeiras, baías e estuários, presente de zero a 570 m, normalmente a 80 m de profundidade, e pode atingir três metros de comprimento total. O cação-bruxa está listado como Criticamente em Perigo pelo ICMBio e IUCN, apesar do cadastro na categoria DD (Dados Deficientes), por falta de informações. Existem registros anteriores de N. cepedianus no litoral paulista, o primeiro registro ocorreu com uma fêmea capturada na região de Cananéia (1968) e o segundo uma fêmea com embriões no litoral paulista (1999). O exemplar deste estudo foi capturado em rede-de-emalhe da pesca artesanal, a 10 km da costa de Peruíbe, em junho de 2016 e doado ao projeto SOS tubarões do Instituto de Biologia Marinha e Meio Ambiente - IBIMM, localizado no bairro do Guaraú, cidade de Peruíbe, litoral Sul de SP, sendo esse o primeiro registro de ocorrência desta espécie na região. O peixe foi identificado como fêmea cação-sete-guelras, Notorynchus cepedianus, com 80 cm de comprimento total e 1,8 kg. O animal apresentou no conteúdo estomacal dois otólitos de peixe ósseo, sendo que na literatura consta que a espécie possui hábito alimentar variado. Os juvenis se alimentam principalmente de teleósteos e com o crescimento à medida que se desenvolvem, modificam seu hábito alimentar tornando-os mais complexos, se alimentando basicamente de teleósteos, crustáceos, cefalópodes, lobos-marinhos, pequenos cetáceos, raias, quimeras e tubarões.
Ocorrência de Tachinobia sp. Boucek, 1977 (Hymenoptera: Eulophidae) em pupas de Sarcophaga (Neobellieria) polistensis Hall, 1933 (Diptera: Sarcophagidae) em Jequié, BA / Occurrence of Tachinobia sp. Boucek, 1977 (Hymenoptera: Eulophidae) in pupae of Sarcophaga (Neobellieria) polistensis Hall, 1933 (Diptera: Sarcophagidae) in Jequié-BA
Authors: Pinheiro Tailan Silva , Santos Rafael de Jesus , Cardoso Jéssica Souza , Lima Lúcio Flávio Freire , Miranda Adrianne Oliveira , Junior Juvenal Cordeiro Silva
Published: July 2021

Este trabalho registra a primeira ocorrência de Tachinobia sp. Boucek, 1977 (Hymenoptera: Eulophidae) parasitando pupas de Sarcophaga (Neobellieria) polistensis (Diptera: Sarcophagidae) Hall, 1933, no estado da Bahia. Os resultados obtidos apontam razão sexual tendenciosa a fêmeas.
Globalization and Curriculum in the 21st Century: A Case for Flexible and Dynamic Curriculum
Authors: Kabanda Mboneza N
Published: July 2021

From the end of the second world war, the awareness of a globalized society has gained power. The theory of globalization is supported by time and space polarity and how these two elements' change affects the world today. This situation concerns all sectors, including education. Indeed, in this era of globalization and competition, educators, researchers, and employers are concerned about the educational institutions' curriculum to prepare students for employment outside their boundaries. Since globalization influences education practices and curriculum worldwide, employees, like products, are shaped by the educational industry in a complex and competitive job market. Thus, the curriculum makers must ensure the preparation of individuals equipped with 21st century skills. This theoretical paper aims to identify how globalization affects educational practices due to competition and how a flexible and dynamic curriculum looks like in the 21st century.  Adaptability, flexibility, and cooperation between developed and developing countries can help train graduates for employment in the 21st century job market.
Ambient Air Quality Monitoring: Impetus, Complexities, Challenges and Solutions
Authors: Tatavarti Rao
Published: July 2021

The poor state of air quality all over the world in general, and across India in particular, is a cause for extreme concern as it is directly and indirectly linked to the deterioration of human health and economies of nations The many complexities and challenges posed by ambient air quality monitoring, prompted the World Health Organization (WHO) to suggest a road map for all nations for the year 2020 -to arrive at a consensus for effective air quality monitoring by all stakeholders –nations and governments, regulatory and controlling bodies, NGOs, scientists and researchers and private citizens.
Penduga Konsisten dari Fungsi Sebaran dan Fungsi Kepekatan Peluang Waktu Tunggu Proses Poisson Periodik
Authors: Azzahra Fatimah , Mangku I Wayan
Published: July 2021

ABSTRAKPenduga yang konsisten dari fungsi distribusi dan fungsi kepekatan peluang waktu tunggu dari proses Poisson periodik dibahas dalam artikel ini. Tidak ada asumsi bentuk parametrik tertentu dari fungsi intensitas proses Poisson periodik. Situasi dipertimbangkan ketika hanya ada realisasi tunggal dari proses Poisson periodik yang teramati dalam interval terbatas [0,n]. Hasil pembuktian menunjukkan bahwa penduga yang diusulkan konsisten ketika n-??. ABSTRACTThe consistent estimator of the distribution and the density functions of the waiting time of a cyclic Poisson process is considered and investigated. We do not assume any particular parametric form of the intensity function of the cyclic Poisson process. We consider the situation when there is only a single realization of the cyclic Poisson process is spotted in a bounded interval [0,n]. We proved that the propose estimators are consistent as n-??.
Pendugaan Imbal Hasil Saham dengan Model Autoregressive Moving Average
Authors: Egeten Grifin Ryandi , Setiawaty Berlian , Budiarti Retno
Published: July 2021

ABSTRAKSeorang investor pada umumnya berharap untuk membeli suatu saham dengan harga yang rendah dan menjual saham tersebut dengan harga yang lebih tinggi untuk memperoleh imbal hasil yang tinggi. Namun, kapan waktu yang tepat melakukannya menjadi tantangan tersendiri bagi para investor. Oleh sebab itu, dibutuhkan suatu model yang mampu menduga imbal hasil saham dengan baik, salah satunya adalah model autoregressive moving average (ARMA). Tujuan dari penelitian ini adalah untuk menerapkan model autoregressive (AR), model moving average (MA), atau model autoregressive moving average (ARMA) pada data observasi untuk menduga imbal hasil saham bank central asia (BCA). Terdapat empat prosedur dalam membangun sebuah model AR, MA atau ARMA. Pertama, data yang digunakan harus weakly stationary. Kedua, orde dari model harus diidentifikasi untuk memperoleh model yang terbaik. Ketiga, parameter setiap model harus ditentukan. Keempat, kelayakan model harus diperiksa dengan melakukan analisis residual untuk memperoleh model yang terbaik. Pada akhirnya, model ARMA (1,1) adalah model terbaik dan akurat dalam menduga imbal hasil saham BCA. ABSTRACTGenerally, investor always wish to be able to buy a stock at a low price and sell it at a higher price to obtain high returns. However, when is the best time to buy or sell it is a challenge for investor. Therefore, proper models are needed to predict a stock return, one of them is autoregressive moving average (ARMA) model. The first purpose of this paper is to apply the autoregressive (AR), moving average (MA) or ARMA models to the observations to predict stock returns. There are four procedures which is used to build an AR, MA, or ARMA model. First, the observations must be weakly stationary. Second, the order of the models must be identified to obtain the best model. Third, the unknown parameters of the models are estimated by maximum likelihood. Fourth, through residual analysis, diagnostic checks are performed to determine the adequacy of the model. In this paper, stock returns of BCA are used as data observation. Finally, the ARMA (1,1) model is the best model and appropriate to predict the stock returns BCA in the future.
fq-derivasi di BM-aljabar
Authors: Yattaqi Egytia , Gemawati Sri , Hasbiyati Ihda
Published: July 2021

ABSTRAK B-aljabar adalah suatu himpunan tak kosong X dengan operasi biner  dan konstanta 0 yang memenuhi aksioma-aksioma tertentu. Suatu bentuk khusus dari B-aljabar adalah BM-aljabar. Adapun hubungan kedua aljabar tersebut, setiap BM-aljabar adalah B-aljabar dan setiap B-aljabar 0-komutatif adalah BM-aljabar. Konsep fq-derivasi telah dibahas di B-aljabar. Pada artikel ini, dibahas konsep fq-derivasi di BM-aljabar. Hasil penelitian yang diperoleh adalah mendefinisikan inside dan outside fq-derivasi di BM-aljabar dan menentukan sifat-sifatnya. Adapun definisi fq-derivasi di BM-aljabar ekuivalen dengan fq-derivasi di B-aljabar, namun pada sifat-sifatnya terdapat perbedaan, yaitu terdapat sifat fq-derivasi yang berlaku di BM-aljabar tetapi secara umum tidak berlaku di B-aljabar. ABSTRACTB-algebra is a non-empty set X with a constant 0 and binary operation satisfying certain axioms. A special form of B-algebra is BM-algebra. Their relationship are every BM-algebra is a B-algebra and every 0-commutative B-algebra is a BM-algebra.  The concept of fq-derivation in B-algebra is discussed. The results define inside and outside fq-derivations in BM-algebra and obtain related properties. Moreover, the definition of fq-derivation in BM-algebra is equivalent to fq-derivation in B-algebra, but there are differences in their properties, which is there are some properties of fq-derivation in BM-algebra, but generally don’t hold in B-algebra.
Hasil Kali Matriks (Mod 2) pada Graf Roda, Graf Pertemanan dan Graf Bunga
Authors: Fran Fransiskus , Saputri Novita Indah , Kiftiah Mariatul
Published: July 2021

ABSTRAKPada artikel ini dibahas sifat-sifat hasil kali matriks (mod 2) terkait graf roda, graf pertemanan, dan graf bunga yang grafikal. Beberapa hasil yang diperoleh, A(Wn)A(Wn)(Mod 2) dan A(Wn)A(Sn)(Mod 2) grafikal apabila n=2k+1 dengan Sn merupakan graf bintang. Selanjutnya, diperoleh A(Wn)A(Go)(mod 2) dan A(Wn)A(G0)(mod 2) grafikal untuk semua n=3 dengan G0 adalah subgraf dari Wn dengan degG0v0=0, degG0vl=degWnvl, untuk 1= l = n. Hasil kali matriks (mod 2) yang grafikal juga diperoleh untuk graf pertemanan dan graf bunga dengan komplemen dan subgrafnya masing- masing. Hasil lebih umum diperoleh untuk kondisi sehingga A(G)A(G)(mod 2) grafikal. ABSTRACTIn this paper, we discussed the properties of the wheel, flower and friendship graphs for which the matrix product under modulo 2 was graphical. Let Sn be a star graph and G0 be a subgraph of Wn where degG0v0=0, degG0vl=degWnvl, for 1= l = n. We proved the matrix product A(Wn)A(Wo)(mod 2)  and A(Wn)A(Sn)(Mod 2) was graphical for n=2k+1 and the matrix product A(Wn)A(Go)(mod 2) and A(Wn)A(G0)(mod 2) was graphical for all n=3. For the next, a graphical matrix product (mod 2) was also obtained for the friendship graph and the flower graph with its complement and subgraph, respectively. As more general results were obtained for conditions such that A(G)A(G)(mod 2) was graphical.
Self-Organizing Map Menggunakan Davies-Bouldin Index dalam Pengelompokan Wilayah Indonesia Berdasarkan Konsumsi Pangan
Authors: Kartikasari Mujiati Dwi
Published: July 2021

ABSTRAKKecukupan konsumsi pangan merupakan salah satu penunjang terbentuknya sumber daya manusia unggul yang menjadi fokus kebijakan pembangunan di Indonesia. Agar konsumsi pangan terpenuhi, salah satu cara yang dapat dilakukan adalah melakukan pengelompokan wilayah berdasarkan konsumsi pangan. Penelitian ini bertujuan untuk mengelompokkan wilayah Indonesia berdasarkan konsumsi pangan berdasarkan data konsumsi kalori per kapita sehari dari berbagai komoditas pangan. Pengelompokan wilayah dilakukan dengan metode self-organizing map (SOM) dengan terlebih dahulu ditentukan jumlah cluster optimum menggunakan nilai Davies-Bouldin Index (DBI) terkecil. Hasil penelitian menunjukkan bahwa hasil cluster optimum yang terbentuk sejumlah 4 cluster dengan jumlah anggota untuk cluster 1 sebanyak 22 provinsi, cluster 2 sebanyak 10 provinsi, cluster 3 sebanyak 1 provinsi, dan cluster 4 sebanyak 1 provinsi.ABSTRACTAdequate food consumption is one of the supports for forming superior human resources, which is the focus of development policies in Indonesia. To fulfill food consumption, one way to be done is to group regions based on food consumption. This study aims to classify regions of Indonesia based on food consumption based on average daily per capita calorie consumption data from various food commodities. Regional grouping is done using the self-organizing map (SOM) method by first determining the optimum number of clusters using the smallest Davies-Bouldin Index (DBI) value. The results showed that the optimum cluster results were 4 clusters with the number of members for cluster 1 as many as 22 provinces, cluster 2 as many as 10 provinces, cluster 3 as many as 1 province, and cluster 4 as many as 1 province.
Graceful Labeling and Skolem Graceful Labeling on the U-star Graph and It’s Application in Cryptography
Authors: Pasaribu Meliana , Yundari Yundari , Ilyas Muhammad
Published: July 2021

Graceful Labeling on graph G=(V, E) is an injective function f from the set of the vertex V(G) to the set of numbers {0,1,2,...,|E(G)|} which induces bijective function f from the set of edges E(G) to the set of numbers {1,2,...,|E(G)|} such that for each edge uv e E(G) with u,v e V(G) in effect f(uv)=|f(u)-f(v)|. Meanwhile, the Skolem graceful labeling is a modification of the Graceful labeling. The graph has graceful labeling or Skolem graceful labeling is called graceful graph or Skolem graceful labeling graph. The graph used in this study is the U-star graph, which is denoted by U(Sn). The purpose of this research is to determine the pattern of the graceful labeling and Skolem graceful labeling on graph U(Sn) apply it to cryptography polyalphabetic cipher. The research begins by forming a graph U(Sn) and they are labeling it with graceful labeling and Skolem graceful labeling. Then, the labeling results are applied to the cryptographic polyalphabetic cipher. In this study, it is found that the U(Sn) graph is a graceful graph and a Skolem graceful graph, and the labeling pattern is obtained. Besides, the labeling results on a graph it U(Sn) can be used to form a table U(Sn) polyalphabetic cipher. The table is used as a key to encrypt messages.
PENYULUHAN FORMULASI SEDIAAN SERBUK TABUR PERONA PIPI EKSTRAK ETANOL BUAH SEMANGKA (Citrullus lanatus)
Authors: Bukit Sari Theresia , Kartika Dewi , Sinurat Jhon Patar
Published: July 2021

One of the fruits in Indonesia that can be used in the cosmetic sector is watermelon. Its red color indicates the high content of lycopene, a natural pigment as a coloring agent in decorative cosmetic formulations, especially blusher. The purpose of this study was to determine whether watermelon extract can be used as a dye in blusher preparations and to determine the formulation of watermelon (Citrullus lanatus) blusher does not cause skin irritation when used. The extract was obtained by maceration using 96% ethanol. The blush formula uses dye from watermelon with a concentration of 15%, 20%, and 25%. The evaluation of preparations includes homogeneity, organoleptic, irritation test, pH test. The results showed that homogeneity, organolepti, and pH of the preparation remained stable for 14 days of storage. The results of the irritation test did not show any irritation.
SEMINAR FORMULASI SEDIAAN PASTA GIGI EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) DAN UJI EFEKTIVITAS TERHADAP BAKTERI Streptococcus mutans
Authors: Rahayu Asvia , Siregar Sa'adah , Sumitra Jhoti , Paradita Annisa
Published: July 2021

Fragrant pandanus (Pandanus amaryllifolius Roxb.) is the only plant in the Family Pandanaceae that has fragrant leaves. This study aims to find out if pandan leaf extract is fragrant. can be formulated into a stable toothpaste gel preparation and has the cause of dental plaque. The test material used pandan leaf extract is fragrant for concentrations of 2%, 3% and 5%. The results of the evaluation of preparations in the form of organoleptic tests, homogeneity, pH, spreadability test, adhesion test, viscosity and frezee-thaw cycling of each formula did not undergo significant changes from week 0 to week 3 which indicates that the preparation has good stability. The data is obtained with results indicating a significant difference between formula 1, formula 2 and formula 3. It is necessary to make formulations using active substances from the partition of fragrant pandan leaf extract (Pandanus amaryllifolius Roxb.)
PELATIHAN PENGOLAHAN SUSU KEDELAI DALAM MENINGKATKAN PRODUKSI ASI DI DESA TANJUNG BERINGIN
Authors: Girsang Desri Meriahta , Manurung Jelita , Ginting Wira Maria , Husna Nadia
Published: July 2021

ASI dengan kualitas produksi yang sedikit tentu menjadi masalah bagi ibu yang sedang berada masa pasca nifas. Ada berbagai faktor yang menjadi penyebab seperti puting yang datar atau tenggelam, payudara ibu yang bengkak, teknik menyusui kurang tepat atau bahkan karena lidah bayi yang pendek. Kegiatan yang telah dilaksanakan ini merupakan suatu pelatihan yang bertujuan untuk memberikan informasi dan meningkatkan kemampuan dalam mengolah bahan pangan (kedelai) sehingga kandungan gizinya lebih meningkat serta lebih efisien dalam konsumsinya untuk capaian tujuan yaitu meningkatnya kualitas produksi ASI. Berbagai penelitian menyatakan bahwa susu kedelai dinilai mampu meningkatkan kualitas produksi ASI. Vitamin E yang terkandung dalam susu kedelai tidak hanya berperan untuk menjaga kesehatan kulit saja melainkan juga berperan dalam meningkatkan produksi hormon phytoestrogen yang dapat membantu kelenjar susu ibu dapat memproduksi ASI lebih banyak. Pengolahan susu kacang kedelai juga dinilai lebih efisien daripada konsumsi obat pelancar ASI yang notabene lebih sulit diperoleh terkhusus di daerah pedesaan. Pemilihan metode pelatihan pada kegiatan PKM ini adalah agar capaian tujuan PKM akan lebih efisien daripada pemberian informasi dengan metode penyuluhan. Pelatihan pengolahan susu kedelai dalam meningkatkan produksi ASI ini diharapkan dapat menjadi solusi bagi permasalahan ibu pasca nifas yang mengalami kurangnya produksi ASI. Jangka waktu pelaksanaan kegiatan PKM ini adalah selama 4 hari dengan jumlah sasaran 50 ibu pasca nifas yang berada di Desa Tanjung Beringin. Pada akhir kegiatan PKM, terdapat peningkatan kemampuan para ibu dalam pengolahan kacang kedelai menjadi susu kedelai.

 

Kata Kunci: Penyuluhan; ASI; Susu Kedelai
PROMOSI KESEHATAN DENGAN PEMBERIAN JUS BAYAM MERAH (AMARANTHUS GANGETICUS) DALAM MENCEGAH ANEMIA PADA IBU HAMIL
Authors: Ginting Keleng Ate , Panjaitan Raini , Cholilullah Andreais Boffil
Published: July 2021

During pregnancy anemia often occurs, anemia is a term that is often used for a decrease in hemoglobin (Hb) levels. Anemia during pregnancy can increase the risk of death during childbirth, give birth to babies with low birth weight, miscarriage and increase the risk of premature birth. Health promotion activities through the provision of red spinach juice can be used as an alternative in socializing the prevention and treatment of anemia in pregnant women. The purpose of implementing community service is to maintain the health quality of pregnant women so that they are not at risk of anemia during pregnancy through health promotion and providing simple treatment through the provision of red spinach juice.

This community service was carried out for two days at the Salma clinic, Perbaungan District. On the first day of the activity, starting from registration, checking hemoglobin levels before giving red spinach juice, delivering material, demonstration of making red spinach juice and giving red spinach juice. On the second day of implementation, checking hemoglobin levels to see changes in hemoglobin levels after giving spinach juice. red. The results of the examination of hemoglobin levels showed that the mean hemoglobin level before administration of red spinach juice to pregnant women was 10.30 and after administration of 10.89 with a median value before administration of 10.15 and after administration of 10.75, SD value before administration of 0. ,6 and the SD value after administration was 0.5 with a minimum hemoglobin level before administration of 10 and after administration of 10, the maximum hemoglobin level before administration was 12 and after administration was 13.

Keywords: Health Promotion; Red Spinach; Hemoglobin Level; Anemia
IMPLEMENTASI STRATEGI PENINGKATAN KEPUASAN PASIEN DI RUMAH SAKIT GRANDMED LUBUK PAKAM
Authors: Sinaga Jon Piter , Rambey Harris , Bangun Sri Melda , Saputri Ika Nur
Published: July 2021

The concept of service quality related to patient satisfaction can be determined by five elements, namely responsiveness, assurance, tangible, empathy and reliability. Patient satisfaction is a level of patient feeling that arises as a result of the performance of health services obtained after the patient compares it with what is expected. Fair and equitable services will be able to lead to satisfaction because the community at this time has begun to be critical in assessing services, especially in the health sector. This community service activity is in the form of measuring the quality of health services as an implementation of patient improvement strategies. Measurement of patient satisfaction is done through filling out a questionnaire sheet which is an instrument for measuring inpatient satisfaction, by patients who are going home. Quality services that provide a health service that is truly in accordance with the needs of the patient and refers to the level of service perfection. The more perfect the health services provided, the better the quality of health services.