bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world data on treatment regimen and medical use among patients in hemophilia B in Korea
Authors: Park Young Shil , Park Ji Kyoung , Park Jeong A , Beak Hee Jo , Lee Jae Hee , You Chur Woo , Lyu Chuhl Joo , Choi Eun Jin
Published: February 2024

Background
We aimed to investigate the real-world treatment status such as treatment regimen, bleeding events, and drug dose of patients with hemophilia B in South Korea.
Methods
In this retrospective chart review study, we collected the data of hemophilia B patients from the 8 university hospitals. Demographic and clinical data, treatment data such as regimen and injection number, factor IX concentrate dose, and bleeding data were reviewed. Descriptive analyses were done with annual data of 2019, 2020, and 2021, respectively as well as consecutive 3 years.
Results
150 hemophilia B patients with medical records between January 1, 2019 and December 31, 2021 were collected. Among those, 72 (48.0%) was severe, 47 (31.3%) was moderate, 28 (18.7%) was mild. The results showed approximately 2 times more patients receiving prophylaxis therapy than on-demand therapy, with 66.1% patients receiving prophylaxis therapy in 2019, 64.9% in 2020, and 72.1% in 2021. Annualized bleeding rate was observed to be 2.2 (±3.1) in 2019, 1.8 (±3.0) in 2020, and 1.8 (±2.9) in 2021 among patients with prophylaxis regimens. For factor IX concentrate doses, patients with prophylaxis regimens received an average of 41.6 (±11.9) IU/Kg/Injection in 2019, 45.7 (±12.9) IU/Kg/Injection in 2020, and 60.1 (±24.0) IU/Kg/Injection in 2021.
Conclusions
In the real-world, prophylaxis is more prevalent than reported. Based on the insights gained from current real-world clinical evidence, it is expected that patients' unmet medical needs can be identified and physicians can consider the patient's situation and actively manage hemophilia B with more effective treatment strategies.
A Comparative Study of Standard and Long-Short Addendum Helical Gear Pair Performance: Multi-Objective Optimization Using Genetic Algorithm
Authors: Akkasaligara Sathyanarayana Achari , Daivagna Umesh M , Banakar Prashanth , Paradeshi Lokesh B
Published: February 2024

This study provides insights into the effectiveness of the genetic algorithm-based optimization process for long-short addendum helical gear pairs, aiming to balance the specific sliding ratio during approach and recess phases while concurrently increasing the load-carrying capacity to the pinion. The iterative process, undertaken with an appropriately chosen population size for the two variables (x1 and x2) over the specified maximum number of generations, consistently yields reliable results, highlighting the algorithm's efficiency and convergence. Visual representations highlight significant addendum modifications, showcasing the algorithm's adaptability to meet specific design criteria for long-short addendum helical gear pairs. The study further explores the reduction in tooth root stress and contact stress of standard helical gears after optimization, determined through finite element analysis using ANSYS software. Additionally, the effects of addendum modification on helix angle and total volume of the gear are examined in detail. A numerical approach is established to calculate the cross-sectional area of the single helical gear tooth in the transverse plane and the total volume of the gear for both standard and optimized long-short addendum helical gears. This approach is validated with real-time CAD models, confirming its accuracy by yielding identical values. In summary, the research underscores the effectiveness of the genetic algorithm-based optimization process for long-short addendum helical gear pairs, with a dual focus on balancing specific sliding ratios and increasing the load-carrying capacity to the pinion, offering valuable insights for advancing such gear configurations in engineering applications.
E2GCO: Event-driven Eye-Gaze-Controlled Operation for Smartphone Interaction
Authors: Liang Dong , Yan Shaoming , Ju Yuanliang , Quan Rong , Tu Huawei
Published: February 2024

Existing gaze-based smartphone interaction methods generally need the auxiliary of hand motions to realize control, and most of them can achieve only simple control operations, which are far from practical smartphone control. To this end, we propose a novel eye-gaze-based smartphone interaction method named Event-driven Eye-Gaze-Controlled Operation ($E^2GCO$), which can realize comprehensive smartphone control operations just using human eyes and gazes. We designed four pairs of eye-gaze-based interaction actions that are easy to implement and distinguish, based on which $E^2GCO$ can control all kinds of smartphone pages. Before the interaction, an anti-jitter strategy-based gaze estimation method is exploited to solve the jitter problem of human eye fixation and detect both accurate and stable human gaze locations on smartphone screens, even when the users are moving. The interaction can be executed more accurately based on the stable and accurate gaze locations. In addition, the event camera technology is introduced in $E^2GCO$ to significantly decrease its power consumption, making $E^2GCO$ more power-efficient to deploy on smartphones. We have implemented the prototype of $E^2GCO$ on different brands of smartphones and conducted a comprehensive user study to validate its efficacy. The user study demonstrates $E^2GCO$'s superior smartphone control capabilities across various scenarios.
Mineral chemistry and geochemistry as proxy for petrogenetic evaluation of charnockites: evidences from Marandahalli, Salem Block of Southern India
Authors: Amarendhar S. , Priya V. Sai Krishna , Vittal M. , Srin M.
Published: February 2024

The present work highlights the petrogenesis of charnockites from the Marandahalli, Dharmapuri District, Tamil Nadu that are conformably emplaced into an older basement of the Precambrian Peninsular Gneissic Complex (PGC). These charnockites form a part of the southern granulitic terrain in the Salem Block (SB) of Tamil Nadu that is marked by diverse lithology that ranges from ultramafic rocks, syenites, quartz-syenites, carbonatites to granites. The charnockites are medium to coarse grained, in-equigranular, displaying porphyroblastic and granophyric textures, and are composed of felsic minerals like plagioclase feldspars (~ 49–66 vol.%), K-feldspar (~ 1–5 vol.%) and quartz. The mafic minerals are dominated by pyroxene (~ 2–7 vol.%) and biotite (~ 1–12 vol.%), and are marked by the absence of garnet. The accessory minerals include magnetite and apatite. The chemistry of these rocks show a distinctive calc-alkaline signatures marked by high SiO2 (~ 65–68 wt.%), Na2O > K2O, with a marginally high CaO (~ 3–5 wt.%), MgO (~ 2.5-4 wt.%) and FeO (~ 1.5-5 wt.%), that are typical of charnockite rocks and they are surmised to have originated from the amphibolite source material and of magnesian nature. The LREE-rich and HREE-depleted patterns indication low degree of partial melting. V, Rb and Ni trace element of the Marandahalli suggest the role of partial melting in the genesis of these rocks. In summary, from the studies carried out it is envisaged that the Marandahalli charnockites melts were derived from amphibolitic sources that are garnet-free.
On the Bessenrodt-Ono type inequality for a wide class of $A$-partition functions
Authors: Gajdzica Krystian
Published: February 2024

The $A$-partition function $p_A(n)$ enumerates those partitions of $n$ whose parts belong to a fixed (finite or infinite) set $A$ of positive integers. On the other hand, the extended $A$-partition function $p_A\left(\bm{\mu}\right)$ is defined as an multiplicative extension of the $A$-partition function to a function on $A$-partitions. In this paper, we investigate the Bessenrodt-Ono type inequality for a wide class of $A$-partition functions. In particular, we examine the property for both the $m$-ary partition function $b_m(n)$ and the $d$-th power partition function $p_d(n)$. Moreover, we show that $b_m(\bm{\mu})$ ($p_d(\bm{\mu})$) takes its maximum value at an explicitly described set of $m$-ary partitions (power partitions), where $\bm{\mu}$ is an $m$-ary partition (a power partition) of $n$. Additionally, we exhibit analogous results for the Fibonacci partition function and the 'factorial' partition function. It is worth pointing out that an elementary combinatorial reasoning plays a crucial role in our investigation.
A Blockchain-Assisted Lightweight Privacy Preserving Authentication Protocol for Peer-to-Peer Communication in Vehicular Ad-hoc Network
Authors: Payattukalanirappel Sharon Justine , Vamattathil Panchami V , Cheeramthodika Mohammed Ziyad C
Published: February 2024

Vehicular Ad-Hoc Network (VANET), provides considerable real-time traffic information services that enhance safety and traffic effectiveness. However, as most of the VANET systems are centralized in nature prone to single-point failure, vulnerable to attacks and there will be reasonable latency in communication. In this paper, while considering the resource-constrained nature of VANET, a lightweight privacy-preserving authentication scheme for peer-to-peer communication using blockchain (DLPA) is proposed. We have designed and deployed smart contracts using Public blockchain to resist the vehicle impersonation attack, to identify illegal vehicle's identity and thereby non-repudiation will be achieved. Vehicle-to-Vehicle (V2V) authentication and peer-to-peer communication are attained without the involvement of a Trusted Authority (TA) and to eliminate the trusted third party who is responsible for generating the key. Furthermore, DLPA has achieved handover authentication of vehicles so that vehicles need not be re-authenticated when they enter into a new Road Side Unit (RSU) limit. The proposed scheme is implemented in different Ethereum powered test networks using Remix IDE to demonstrate the feasibility and to analyze the performance of the smart contract in terms of transaction cost and execution cost. In addition to that, security proof and analysis are performed to unveil that our proposed scheme preserves the privacy of the communicating parties, semantic security of the session key, and resistance against various known threats and attacks. Finally, the performance analysis of the scheme is done by calculating the communication and computation costs. While analyzing the result, the proposed protocol has a minimal cost when compared with other blockchain-based authentication schemes in VANET.
Optimization of lattice steel structures. A parametric approach based on statically determined structures
Authors: Tarabay Murilo A. K. , Lima Leonardo S.
Published: February 2024

Although several optimization methods have been developed in recent years, their application in real projects is still not widespread due to the complexity of implementation. This paper presents a simplified practical methodology for optimizing trussed steel structures with a focus on the feasibility of the structural solution. The proposed method is parameterized based on statically determined structures with topologies inspired by Michell trusses. In the examples evaluated, the reduction in self-weight reached 24.6% combined with a reduction in displacements of 29,3% in relation to conventional structures.
Body Image and Quality of life undergoing totally robotic versus robotic- assisted distal gastrectomy: A retrospective propensity score matched cohort study
Authors: Ju Hou-qiong , Yuan Yu-li , Yu Hong-xin , Gao Geng-mei , Liu Ya-xiong , Liang Ya-hang , Li Tao , Liu Yang , Liu Dong-ning , Li Tai-yuan
Published: February 2024

Background
With the improvement of anastomotic techniques and the iteration of anastomotic instruments, robotic intracorporeal suturing has become increasingly proficient. The era of fully intracorporeal anastomosis in robotic gastric cancer resection is emerging. This study aims to explore the impact of totally robotic distal gastrectomy (TRDG) and robotic-assisted distal gastrectomy (RADG) on patients' quality of life and survival.
Patients and Methods
This study is a comparative retrospective study of propensity score matching. This study included 306 patients who underwent robotic distal gastrectomy for gastric cancer between June 2016 and December 2022 at our center. Covariates used in the propensity score included sex, age, BMI, ASA score, maximum tumour diameter, degree of histological differentiation, Pathological TNM stage, Pathological T stage, Pathological N stage, and Lauren classification. Outcome measures included operative time, intraoperative bleeding, time to first venting, time to first fluid intake, postoperative hospital stay, total hospitalization cost, total length of abdominal incision, postoperative complications, inflammatory response, body image, quality of life, Disease-Free Survival (DFS), and Overall Survival (OS).
Results
According to the results of the study, compared with the RADG group, the TRDG group had a faster recovery time for gastrointestinal function (P = 0.025), shorter length of abdominal incision (P < 0.001), fewer days in the hospital (P = 0.006) less pain (P < 0.001), less need for additional analgesia (P = 0.013), and a postoperative white blood cell count (P < 0.001) and C-reactive protein content indexes were lower (P<0.001). In addition, the TRDG group had significantly better body imagery and cosmetic scores (P = 0.015), physical function (P = 0.039), role function (P = 0.046), and global function (P = 0.021) than the RARS group. Meanwhile, the TRDG group had milder symptoms of fatigue (P = 0.037) and pain (P < 0.001). The PASQ Total Subscale Score (P < 0.001) and Global Subscale Score (P < 0.001) were significantly lower in the TRDG group than in the RADG group at postoperative 3 months. OS and DFS were not significantly different between the two groups (P = 0.236, P = 0.179).
Conclusion
Totally robotic distal gastrectomy has a smaller incision, faster gastrointestinal recovery time, fewer days of postoperative hospitalization, and lower inflammatory markers than robotic-assisted distal gastrectomy. At the same time, postoperative cosmetic and quality of life outcomes were satisfactory.
Changing Trends in the Penile Prothesis Implantation of male with refractory Erectile Dysfunction in China
Authors: Zhang Chenwang , Bai Haowei , shi Chenkun , Chen Huirong , LI Peng , Huang Yuhua , chen huixing , Zhao Fujun , Yao Chencheng , Li Zheng , Zhi ER LEI
Published: February 2024

Background
This study aims to investigate the changing trends in the penile prothesis implantation(PPI) of male with refractory erectile dysfunction(ED) in China.
Method
We retrospectively reviewed medical records from January 2019 to October 2023 to identify men who had undergone PPI in China. We also retrospectively reviewed medical records of PPI we had undergone during that time at Shanghai General Hospital.
Results
The overall trajectory of PPI surgeries exhibits an upward trend in China. Concurrently, the expertise in this surgical technique is currently limited to a minority of surgeons. A total of 112 patients were included in the study. Median age was 39[27–63] years, median International Index of Erectile Function-5 score (IIEF-5) significantly improved from 10.23 ± 1.26 to 22.6 ± 2.73. The causes of severe ED were: vasculogenic tower (n = 58, 51.8%), diabetes (n = 21,18.8%) and pelvic/spinal cord injury (n = 14, 12.5%). Overall satisfaction rate for the PPI surgery was 93.0% for men and 90.4% for their partners. The 3-year PPI survival rate was 87%.
Conclusion
The prevalence of PPI has witnessed a steady increase since 2019 in China, indicating a growing acceptance and endorsement of this surgical intervention among both patients and andrological practitioners for the treatment of severe ED. PPI is a safe and effective treatment option for Chinese patients with refractory ED and experienced surgeon perform PPI according to standard PPI procedure could reduce the complications and improve sexual satisfaction of patients and sexual partners .
Raw Milk Quality and Handling Practices by Pastoral Communities at Cattle Camps in Rejaf East, South Sudan
Authors: Aguer Elijah Majok Kiir , Augustino Serafino Musa Abdelkarim , Rapheal Wangalwa , Jeninah Atwebembeire
Published: February 2024

Food safety including imported food and produced food, is a major issue for South Sudan. An effective safety food control system for guiding and eliminating hazardous food from the market is lacking. Milk is one of the food products consumed in South Sudan; however, there is limited information regarding its handling and safety, especially among pastoral communities. Therefore, this study assessed raw milk quality and handling practices by pastoral communities at cattle camps in the Rejaf East, South Sudan. The study was conducted in three cattle camps (Highland, Kadoro, and Jebel Amianin) of the Rejaf East. Raw milk handling practices in the cattle camps were assessed using a questionnaire and observation checklist among 240 households selected randomly. The physicochemical and microbial parameters were assessed in 75 samples of raw milk using standard methods. The findings revealed that milking handling practices at cattle camps are characterized by hygienic and unhygienic practices. The pastoral communities had no access to a cooling system for milk storage. Additionally, 90.8% of the households in cattle camps consumed unboiled raw milk, and 10% of the households experienced milk rejection at the point of milk sale. The overall means of the physicochemical parameters of the milk samples were as follows: fat = 7.76 ± 1.47%, SNF = 7.68 ± 0.26%, density = 1.03 ± 0.00 g/ml, lactose = 4.21 ± 0.15%, protein = 2.81 ± 0.09%, freezing point = -0.51 ± 0.030C, and pH 6.60 ± 0.21. The results of the microbiological quality of the raw milk indicated that the highest TVC (5.81 ± 0.51 logCFU/ml) was recorded in Jebel Amianin; on the other hand, the highest TCC (4.64 ± 0.21 logCFU/ml) was recorded in Kadoro, and the highest TSC (2.53 ± 0.31 logCFU/ml) was recorded in Highland Boma. The study indicated that pastoralists in cattle camps do not observe hygienic practices, including drying hands after handwashing or washing with udder and teats before milking. Furthermore, the study showed that the microbiological quality of raw milk samples obtained from the Rejaf East has a high bacterial load; therefore, there is a need to improve hygiene practices in milk production.
Investigation and correlation analysis of financial toxicity and risk of suicide in the patients with head and neck cancer in China
Authors: Sun Meng-chen , Feng Fang-ming , Wang Xiu-yu , Yang Fang-fang , Zhao Mei-hui , Meng Jing
Published: February 2024

Background
To understand the current state of financial toxicity and suicide risk in head and neck cancer patients,to investigate the correlation between the level of financial toxicity and suicide risk in head and neck cancer patients,and to provide a basis for reducing the level of financial toxicity and the risk of suicide in head and neck cancer patients.
Methods
A cross-sectional survey was conducted,from March 1 to July 31,2022,150 head and neck cancer patients were selected from Oncology Department of East Hospital Affiliated to Tongji University by convenient sampling method.The survey was carried out by means of the general questionnaire,Comprehensive Score for Financial Toxicity based on the Patient-Report Outcome Measures(COST-PROM),Cancer Suicide Risk Scale(CSRS),and then analysis the datum.
Results
The score of COST-FROM of 150 head and neck cancer patients was (18.00±6.12) points,and the score of CSRS of head and neck cancer patients was (36.31±8.51) points.The total score of economic toxicity was significantly negatively correlated with the total score of suicide risk and its dimensions (r values were − 0.446 to 0.235,all P<0.05).The total score of suicide risk was negatively correlated with the total score of economic toxicity and the scores of each dimension (r values were − 0.446 to -0.251,all P<0.05).
Conclusion
Patients with head and neck cancer were at higher risk of suicide,and financial toxicity was a significant contributing factor to suicide risk,with higher levels of financial toxicity associated with a higher risk of suicide.Reducing the level of financial toxicity in patients with head and neck cancer has important implications for reducing their risk of suicide.
Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak
Authors: Park Ji Eun , Yang Jieun , Han Sanghoon , Hana Chi Wha , Yoo Jeong Rae , Kim Misun , Lee Donghyoun , Jo Jaemin
Published: February 2024

Purpose
Intensive cytotoxic chemotherapy increases the risk of infection in patients with cancer by inducing bone marrow suppression and mucosal injury. Febrile neutropenia (FN) is the most important clinical adverse event in patients with cancer who receiving cytotoxic chemotherapy. To prevent FN, prophylactic antibiotics, colony stimulating factors (CSFs) and also standard precautions including hand and respiratory hygiene are generally recommended but the exact effect of non-pharmacologic intervention such as standard precaution has not been clearly proven in the clinical setting. we aimed to compare the incidence of FN between pre-coronavirus disease 19 (COVID 19) era versus post-COVID 19 era.
Material and methods
We retrospectively enrolled patients with breast cancer who received adjuvant adriamycin and cyclosphosphamide (AC) chemotherapy at Jeju national university hospital.
Results
In total, 149 patients well enrolled, including 94 who received AC chemotherapy in pre-COVDI 19 era and 55 who received at post-COVID 19 era. Sixteen (10.7%) patients experienced the FN. Fourteen events (14.9%) and two events (3.6%) were occurred in pre-COVID 19 and post-COVDI 19 era, respectively. The post-COVID 19 era was the only risk factor for FN. (p = 0.032)
Conclusion
We found an association between FN occurrence and COVID 19 outbreak; thus, providing indirect evidence of the importance of non-pharmacological measure to reduce FN risk in patients with cancer. Further research is required to confirm the standard precautions for FN prevention in patients with cancer.
Experimental study on visualization of seepage flow and grout diffusion and seepage reduction patterns in rough single fissure
Authors: Tan Chunzhi , Qian ziwei , Wang bingzhu
Published: February 2024

The study of fissure seepage and grouting diffusion, seepage reduction law is of great significance for the prevention and control of water damage in fissured rock bodies. To this end, a visualization test model based on the morphology of real rock fissures was prepared in bulk using 3D scanning and 3D printing technology, and tests were carried out to realize the visualization of seepage flow in a single fissure, grouting with different water-cement ratios, and seepage flow after the fissure grouting was consolidated and filled. The test results show that: compared with grouting diffusion, the seepage of water injection into the fissure is different in activity and coverage; the rough single fissure seepage shows nonlinear flow characteristics, and is a composite flow form of laminar and turbulent flow; the grouting into the fissure has the effect of climbing and swooping, and the diffusion rate and filling rate of the grout are obviously different under different water-cement ratio conditions; after the grout is filled and consolidated in the fissure, the permeability coefficient of the fissure is greatly reduced, and the seepage performance is significantly different. After the slurry is filled and consolidated in the fissure, the permeability coefficient is greatly reduced, and the seepage flow is nonlinear, which conforms to the Forchheimer's equation, and with the decrease of the water-cement ratio of the cement slurry, the coefficient of the linear term decreases, and the coefficient of the nonlinear term increases and accounts for a larger proportion in the binomial.
WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma
Authors: Hu Junxi , Xu Jinye , Tian Shuyu , Zhang Dong , Wang Xiaolin , Shu Yusheng
Published: February 2024

Background DnaJ Homolog Subfamily C Member 5B (DNAJC5B), as a member of the heat shock protein family, has not yet been fully clarified in its role in tumor development, making it particularly important to study its potential role in the immunotherapy of esophageal cancer.
Methods This study utilized the esophageal cancer dataset from the TCGA database, selecting genes associated with DNAJC5B expression through Pearson correlation analysis, followed by Gene Ontology (GO) functional enrichment analysis and KEGG pathway analysis. Additionally, single-cell RNA sequencing data was used to analyze DNAJC5B expression in different T cell subgroups. The prognostic value of DNAJC5B was evaluated using Kaplan-Meier survival curves, receiver operating characteristic (ROC) curves, and Cox proportional hazards model analysis.
Results DNAJC5B is highly expressed in patients with advanced esophageal cancer, especially in males. Immunohistochemical staining results indicate a notable enrichment of DNAJC5B in the cytoplasm of cancer tissue cells. GO and KEGG analysis indicated significant correlations between DNAJC5B expression and immune-related processes like adaptive immune response and cell surface receptor signaling pathways. Single-cell analysis showed that DNAJC5B predominantly accumulates in CD8+ T cells and is associated with cell activation state. Survival analysis indicated that patients with high DNAJC5B expression had a median survival of 681 days, markedly lower than the 1361 days in those with low expression. Both univariate and multivariate Cox proportional hazards model analyses identified DNAJC5B as an independent prognostic factor in ESCC patients.
Conclusion This study suggests that DNAJC5B may play a significant immunomodulatory role in esophageal cancer, particularly in regulating CD8+ T cell function and tumor immune escape. These findings support the potential of DNAJC5B as a biomarker for treatment and prognosis evaluation in esophageal cancer, providing new strategic directions for immunotherapy of esophageal cancer.
Combined biological effects of CBCT and therapeutic X-ray dose on chromosomal aberrations of lymphocytes
Authors: Gáldi Ádám , Farkas Gyöngyi , Hegyesi Szilvia Gazdag , Koszta Enikő , Ágoston Péter , Pesznyák Csilla , Major Tibor , Takácsi-Nagy Zoltán , Polgár Csaba , Jurányi Zsolt
Published: February 2024

Background and purpose: Cone Beam Computed Tomography (CBCT) is routinely used in radiotherapy to localize target volume. The aim of our study was to determine the biological effects of CBCT dose compared to subsequent therapeutic dose by using in vitro chromosome dosimetry.
Materials and methods: Peripheral blood samples from five healthy volunteers were irradiated in two phantoms (water filled in-house made cylindrical, and Pure Image CTDI phantoms) with 6 MV FFF X-ray photons, the dose rate was 800 MU/min and the absorbed doses ranged from 0.5 Gy to 8 Gy. Irradiation was performed with a 6 MV linear accelerator (LINAC) to generate a dose-response calibration curve. In the first part of the investigation, 1-5 CBCT imaging was used, in the second, only 2 Gy doses were delivered with a LINAC, and then, in the third part, a combination of CBCT and 2 Gy irradiation was performed mimicking online adapted radiotherapy treatment. Metaphases were prepared from lymphocyte cultures, using standard cytogenetic techniques, and chromosomal aberrations were evaluated. Estimate doses were calculated from chromosome aberrations using dose-response curves.
Results: Samples exposed to X-ray from CBCT imaging prior to treatment exhibited higher chromosomal aberrations and Estimate dose than the 2 Gy therapeutic (real) dose, and the magnitude of the increase depended on the number of CBCTs: 1-5 CBCT corresponded to 0.04-0.92 Gy, 1 CBCT+ 2 Gy to 2.32 Gy, and 5 CBCTs + 2 Gy to 3.5 Gy
Conclusion: The estimated dose based on chromosomal aberrations is 24.8 % higher than the physical dose, for the combination of 3 CBCTs and the therapeutic 2Gy dose, which should be taken into account when calculating the total therapeutic dose that could increase the risk of a second cancer. The clinical implications of the combined radiation effect may require further investigation.
Shoreline change assessment and Wave Modeling on the Mostaganem Coast, Algeria
Authors: sallaye miloud , Dahmani Abd El Alim , cherif Youssra salem , Mezouar Khoudir
Published: February 2024

The coastal area of Sidi Madjedoub East to Oureah West is a very interesting and remarkable place. In the last 20 years, it is exposed to a series of natural and anthropogenic processes that generate short and long time variation. This research is based on the spatial-temporal analysis of the shoreline change along the coast between Sidi Madjedoub to Oureah, by using aerial photographs (2003) and quick-bird satellite images (2014 and 2023). The shoreline changes were calculated on 720 transects generated at intervals of 20 m. The Digital Shoreline Analysis System (DSAS) was used on the modelled shoreline. The results reveal that most of the area studied is undergoing erosion, with a mean rate change of -0.28 meters per year for the whole coast. In addition, numerical modelling of wave propagation was applied out using the Mike 21 model to get a better understanding of the influence of coastal hydrodynamics to shoreline change. This change in shoreline is principally due to human activities (sand mining, urbanization) and natural factors (currents, waves, storms). We can conclude that coastal morphology and the erosion and accretion of coastal zones are influenced by both natural and human activities.
MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries
Authors: KalantaryArdebily Nahid , Feldbush Anna C. , Gurari Netta
Published: February 2024

Accurate perception of tactile information is essential for performing activities of daily living and learning new sensorimotor skills like writing. Deficits in perceiving tactile stimuli are associated with severity in physical disability. The mechanisms contributing to tactile deficits in individuals with brain injuries remain poorly understood in part due to insufficient assessment methods. Here, we provide a tactile stimulator system for studying the neural mechanisms contributing to tactile deficits in individuals with brain injuries during functional magnetic resonance imaging (fMRI). This tactile stimulator system consists of a pneumatically-controlled inflatable and deflatable balloon that interfaces with a digit of the hand to provide small forces. The magnitude of the applied force is delivered and controlled by modifying the air pressure in the balloon. The tactile simulator provides an 8,mm diameter tactile stimulus. The device's interface at the finger is compact, allowing it to be used with individuals who have a closed-fist posture following brain injury such as stroke or cerebral palsy. The tactile stimulator contains no metallic components and can be used in MRI research. The tactile stimulator system can repeatedly apply a force between 1,N and 2.4,N. This tactile stimulator system addresses limitations in past fMRI methodologies for assessing tactile perception by providing precise and repeatable force stimuli to a small area of the finger. Custom software automates the application of the force stimuli and permits synchronization with acquired fMRI data. This system can be used in subsequent testing to investigate deficits in sensory functioning in those with brain injuries.
The Conceptualization of Cardiometabolic Disease Policy Model in the UK
Authors: Putri Septiara , Ciminata Giorgio , Lewsey Jim , Jani Bhautesh , McMeekin Nicola , Geue Claudia
Published: February 2024

Background
Decision models are increasingly used to inform the policy-making processes, and there is a need to improve their credibility. The estimation of health and economic outcomes generated from the decision models is influenced by the development process itself. This paper aims to present the conceptual model development process of cardiometabolic disease (CMD) policy models in the UK setting.
Methods
This conceptual model followed the International Society of Pharmacoeconomics and Outcomes Research-Society of Medical Decision Making (ISPOR-SMDM) Modelling Good Research Practices Task Force-2.
Results
First, for the conceptualization of the problem, the CMD disease staging, progression, and current clinical guidelines are summarized. We critically appraised published CMD models such as cardiovascular disease (CVD) and type 2 diabetes (T2DM). Key challenges of the modelling from this review include the importance of understanding complex risk factors, the economic perspective used, the need to improve the validation process of the state transition model, model structure, and assumptions. Second, as a sequential process, is model conceptualization, to determine which modelling types and their attributes best represent the defined problem. Expert opinions, including a clinician and experienced modellers, provided some input on the state transition model to ensure the structure is clinically relevant. From this stage, Atrial Fibrillation (AF) is considered as a potential covariate, removing further complication state for T2DM, and reconsidering myocardial infarction (MI) as a CHD state.
Conclusion
This conceptual model serves as a basis for representing the systematic process for structuring the CMD policy model to enhance its transparency and credibility.
Estimating Carrier Rates and Prevalence of Porphyria-Associated Gene Variants in the Chinese Population Based on Genetic Databases
Authors: Wang Yi Nan , Li Nuo Ya , Zhang Song Yun
Published: February 2024

Porphyria is a group of rare metabolic disorders caused by mutations in genes that encode crucial enzymes in the heme biosynthetic pathway. However, the lack of comprehensive genetic analysis of porphyria in the Chinese population makes it challenging to identify and diagnose carriers of the condition. Using the ChinaMAP database, we determined the frequencies of P/LP porphyria-associated gene variants according to the ACMG guidelines. We also calculated the carrier rates and prevalence for each type of porphyria in the Chinese population under the Hardy-Weinberg equilibrium (HWE). Compared with the gnomAD database, the genetic spectrum of porphyria-related P/LP variants in the Chinese population is distinct. In the ChinaMAP database, we identified 23 of these variants. We estimated the carrier rates for autosomal dominant porphyria (AIP, HCP, VP, PCT) in the Chinese population to be 1/1059, 1/1513, 1/10588, and 1/1765, respectively. For autosomal recessive porphyria (ADP, EPP, HEP, CEP), we estimated carrier rates of 1/5294, 1/2117, 1/1765, and 1/2647, with predicted prevalence rates of 1/112105744, 1/13312, 1/12456194, and 1/28026436, respectively. Notably, 12 of the variants we identified were unique to the Chinese population. The predicted prevalence rate of EPP is the highest among the various types of porphyria in the Chinese population, while the others are moderate to low. This study is the initial comprehensive genetic research on porphyria in the Chinese population. By outlining the genetic characteristics of various porphyria types among the Chinese, it provides scientifically sound reference data necessary for both research and genetic screening to identify porphyria carriers.
Impact Of KPD and NRG Flavonoids On Neurotoxicity Prompted By Aluminum Chloride Through Hindrance Of Oxidative Pressure : In Vivo Model
Authors: Nalla Swathi , Ganta Suhasin , Bukke Sarad Pawar Naik , Bandaru Nagaraju
Published: February 2024

Background:
The incidence of neurodegenerative diseases has skyrocketed alongside the extension of the average human lifespan. Oxidative stress is a hallmark of this group of diseases, its involvement in disease onset and/or progression is incompletely understood. Polyphenols are among the most promising natural compounds for their neuroprotective capabilities due to their distinctive chemical characteristics. So, it's exciting to look at the possibility of using new compounds with polyphenol qualities as neuroprotective. The goal of this study was to test the neuroprotective effect of the polyphenolic flavanol molecules Kaempferide and Norbergenin, in-vivo disease models generated by Aluminium chloride (AlCl3).
Results:
Therefore, this study was evaluated to estimate the alleviative effect of KPD and NRG against AlCl3 Induced neurotoxicity in rats. KPD (10 mgkg-1) and NRG (10 mgkg-1) supplemented group decreased the production of Amyloid and Tau Proteins. The anti-oxidants i.e., catalase (CAT), glutathione reductase (GSR), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were reduced, besides malondialdehyde (MDA) & reactive oxygen species (ROS) contents were substantially (P < 0.05) elevated. Western blot analysis was performed AlCl3 exposure also prompted remarkable histopathological alterations in Brain tissues.
Conclusion:
KPD and NRG therapy, protect all the brain tissues from the damages induced byAlCl3. The findings of our study demonstrated that KPD can efficiently exerts protective effect due to its anti-oxidant, & neuroprotective effect.
The solar corona spectroscopic analysis, the ionized iron line formations and the Argon X detection during theTotal Solar Eclipse of 21 August 2017
Authors: Voulgaris Aristeidis G. , Mouratidis C. , Tziotziou K. , Economou T.
Published: February 2024

We present an analysis of the solar corona visual spectrum, captured during the total solar eclipse of 21 August 2017, in Salem, Oregon USA. The eclipse took place about 2 years before the solar minimum of the 25th solar cycle, that occurred on 2019/2020. The spectra were captured by two slitless spectrographs with different dispersions and include the two principal coronal emission lines Fe XIV and Fe X. Following the continuum subtraction of the K-corona, the very faint coronal emission line of Ar X 5533 A was detected. The slitless spectrograph also recorded the distribution of Ar X around the solar limb, which was compared to the distribution of the two principal ionized iron lines. A correlation between the distributions of Ar X and Fe XIV has been identified and an explanation is provided for the Ar X presence in the solar corona around the solar minimum periods. Simultaneous observations with the two-channel Lyot filter, tuned at the green and red coronal lines of iron, revealed different formations and structures that exist at the eastern solar limb, high in the corona and appearing at extended solar latitudes. Due to the moisture presence in the Earth's atmosphere, all obtained spectra during the solar eclipse contain also strong absorption lines of water vapor.
Long non-coding RNA LINC-PINT is associated with favorable prognosis in cancer patients: a meta-analysis
Authors: Koh Hyun Min , Hyun Chang Lim , Lee Dong Hui , Park Sungjoon , Han Nayoung
Published: February 2024

Background
There is growing evidence that long non-coding RNA long iatrogenic non-protein-coding RNA p53-induced transcript (LINC-PINT) is highly expressed in cancer tissue and is associated with the prognosis of cancer patients. The present study systematically analyzed the prognostic significance of LINC-PINT expression in cancer patients.
Methods
We collected eligible studies through the PubMed, Embase, and Cochrane library searches until February 1, 2024. The prognostic significance of LINC-PINT expression was evaluated by conducting a meta-analysis.
Results
Eleven eligible studies with 2876 cancer patients were collected. The pooled results revealed that LINC-PINT expression was associated with favorable overall survival (OS) and disease-free survival (DFS) in cancer patients (for OS, hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.64–0.80, p < 0.001; for DFS, HR 0.70, 95% CI 0.60–0.82, p < 0.001).
Conclusion
LINC-PINT expression was associated with favorable OS and DFS, and it may serve as a valuable prognostic marker in cancer patients.
Diagnostic value of T-tube cholangiography and choledochoscopy in residual calculi after biliary surgery, Is T-tube cholangiography necessary before T-tube removal？
Authors: Li Saixin , Wang Zheng , Li Zheng , Wang Kenan , Sui Minghao , Liu Dongbin , Zheng Yamin , Liang Kuo
Published: February 2024

Background
T-tube cholangiography and choledochoscopy are commonly employed techniques for assessing residual bile duct stones following biliary surgery. Further investigation is warranted to determine the utility of routine cholangiography prior to T-tube removal. It is imperative to explore the diagnostic efficacy of various examination methods for detecting residual calculi post-biliary surgery.
Methods
The clinical data of 287 patients who underwent T-tube angiography and choledochoscopy following choledochotomy and subsequent T-tube drainage at the Department of General Surgery, Xuanwu Hospital, Capital Medical University from 2017 to 2022 were retrospectively analyzed. All patients underwent both cholangiography and choledochoscopy six to eight weeks after laparoscopic cholecystectomy combined with common bile duct exploration and T-tube drainage surgery. The results of T-tube cholangiography and choledochoscopy for each patient were recorded, followed by analysis and comparison.
Results
Among the cohort of 287 patients, T-tube cholangiography revealed 38 cases of residual stones, which were subsequently confirmed by choledochoscopy in 29 cases. Conversely, among the remaining 249 patients who exhibited no evidence of residual stones on T-tube angiography, a single patient was later verified to have retained stones through choledochoscopy. The results of T-tube cholangiography and choledochoscopy showed no significant difference (P = 0.82), indicating a high level of agreement between the two methods (Kappa value: 0.70).
Conclusion
The simultaneous performance of T-tube cholangiography and choledochoscopy after biliary surgery is recommended to enhance the diagnostic accuracy of residual stones and reduce the incidence of bile duct stone remnants.
Spin orbit resonance cascade via core shell model. \Application to Mercury and Ganymede
Authors: Pinzari Gabriella , Scoppola Benedetto , Veglianti Matteo
Published: February 2024

We discuss a model describing the spin orbit resonance cascade. We assume that the primary has a two-layer (core-shell) structure: it is composed by a thin solid crust and an inner and heavier solid core that are interacting due to the presence of a fluid interface. We assume two sources of dissipation: a viscous one, depending on the relative angular velocity between core and crust and a tidal one, smaller than the first, due to the viscoelastic structure of the core. We show how these two sources of dissipation are needful for the capture in spin-orbit resonance. The crust and the core fall in resonance with different time scales if the viscous coupling between them is big enough. Finally, the tidal dissipation of the viscoelastic core, decreasing the eccentricity, brings the system out of the resonance in a third very long time scale. This mechanism of entry and exit from resonance ends in the 1 : 1 stable state.
Democratising HPC Training: co-creating an Industrial HPC Nano Online Course
Authors: Ziouvelou Xenia , Karozis Stelios , Blazkova Martina , Karkaletsis Vangelis
Published: February 2024

Purpose: Disruptive technologies (AI, IoT, etc) unlock new frontiers of data-centric innovation. This increases the computational needs, pushing more and more companies into the HPC space. However, although HPC is a key tool for processing and analysing the constantly growing volume of data across numerous application areas many companies remain reluctant to use HPC and move their HPC workloads to the cloud, which may be attributed to the inadequate understanding about HPC and its potential benefits, cost, security and performance aspects. At the same time, existing HPC training, mainly focus on the research and academic community, thus creating a gap in the provision of industrial HPC training and addressing the supercomputing knowledge skills of enterprises.
Methods: Towards this aim, this paper presents an example of “massively” co-created education and training HPC module, namely an HPC NOOC (Nano Open Online Course), targeting industrial learners. This open, agile co-creation approach incorporates key components of the European HPC ecosystem and beyond, aiming to offer a paradigm for success in the democratisation of HPC knowledge, and the co-creation of educational value aiming to reach a wide impact (i.e., educational, technological, innovation, economic impact, etc).
Results: The proposed HPC NOOC has been designed in an agile format so as to enable its ongoing evolution and expansion across emerging themes and indicative success stories across Europe and the world.
Conclusion: Acknowledging the importance of HPC as a strategic investment for Europe and the world, this paper, aims to contribute to the democratisation of HPC training for industry and narrowing the gap between HPC adoption for micro, small and medium sized enterprises is important in order to reap the benefits of HPC innovations.
Radiation Health Risk to Human Scavengers at Refuse Dumpsites in Calabar, Nigeria
Authors: Inyang Samuel O. , Ekong Isaac
Published: February 2024

Introduction
Refused dumpsites are known to be associated with enhanced level of ionizing radiation depending on the items that constitute the refuse. Exposure to chronic levels of exposure from these refuse dumpsites could result in severe health risk.
Materials and Methods
Calabar was divided into three sections depending on the location for ease of data collection. The dumpsites in each section were identified by their geographical coordinates using geographical positioning system (GPS) device. Exposures were measured using an exposure meter in µSv/h and converted to annual effective dose rate in mSv/yr. The effective dose rate values were used in evaluating the cancer incidence and mortality for male and female using conversion factors in BEIR VII.
Results
The annual effective dose rates for the waste dumpsites in Calabar ranged from 0.15 – 0.36 mSv/yr, with one dumpsite in Section C having the highest value annual effective dose rate of 0.36 mSv/yr. The corresponding observed maximum values of cancer incidence for male and female respectively were 110 and 154 persons per 100,000 persons while the cancer mortality for male and female were respectively 61 and 86 persons per 100,000 persons.
Conclusion
The study shows enhanced levels of ionizing radiation around waste dumpsites in Calabar. The effective dose rates were lower than the established occupational effective dose. The cancer incidence and mortality evaluated for males and females were low. However, there is need to control the activities of scavengers around the waste dump to further minimize the cancer risk.