bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionic self-assembly of pillar[5]arenes: proton-conductive liquid crystals and aqueous nanoobjects with encapsulation properties
Authors: Marín Iván , Merino Rosa I. , Barberá Joaquín , Concellón Alberto , Serrano José L.
Published: October 2023

An easy and fast method to functionalize pillararenes through ionic bonds to obtain interesting materials for their encapsulation properties and proton conduction.
Highly stable and strain-insensitive metal film conductors via manipulating strain distribution
Authors: Zhu Ting , Wu Kai , Wang Yaqiang , Zhang Jinyu , Liu Gang , Sun Jun
Published: October 2023

This work proposes a novel in-plane crack control strategy of engineering hierarchical microstructures to achieve outstanding electromechanical performance via harnessing the strain distribution in metal films.
Reflections from Seth Marder on 10 years of Materials Horizons
Authors: Marder Seth R
Published: October 2023

Inaugural Editorial Board Chair Seth Marder reflects on the early days of the journal in celebration of the 10th anniversary of Materials Horizons.
Viscoelastic fluid flow over a horizontal flat plate with various boundary slip conditions and suction effects
Authors: Sudarmozhi K. , Iranian D. , Memon M. Asif , Selvi P. D. , Khan M. Sabeel , Fenta Amsalu
Published: October 2023

This study examines the numerical representation of fluid flow on the Maxwell model in a double-diffusive boundary layer over a horizontal plate.
A comprehensive strategy for quality marker discovery using chemical profiling combined with chemometrics, machine learning and network pharmacology analysis: taking Sinomenii Caulis as an example
Authors: Zhang Zhiyong , Ren Mingjun , He Mulan , Zhu Yongbo , Huang Yuming , Qiu Ping , Hu Yunfei , Li Wenlong
Published: October 2023

A comprehensive strategy for screening the quality markers of SC.
Recent asymmetric synthesis of natural products bearing an α-tertiary amine moiety via temporary chirality induction strategies
Authors: Jeon Hongjun , Kim Jae Hyun , Kim Sanghee
Published: October 2023

This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.
Facile microfluidic synthesis of monodispersed size-controllable quantum dot (QD) microbeads using custom developed QD photoresist
Authors: Kim Byeongseok , Kumar Samir , Chon Bumsoo , Son Ho-Jin , Kang Sang Ook , Seo Sungkyu
Published: October 2023

Simple and effective strategy for producing quantum dot microbeads (QD-MBs) with controllable sizes, which can be crucial in diverse fields such as biosensing, drug delivery, and imaging.
Palladium-catalyzed stereoselective construction of chiral allenes bearing nonadjacent axial and two central chirality
Authors: Liu Li-Xia , Huang Wen-Jun , Yu Chang-Bin , Zhou Yong-Gui
Published: October 2023

An enantioselective synthesis of substituted chiral allenes with nonadjacent axial and two central chiral centers is reported, using a combination of retro-oxa-Michael addition and palladium-catalyzed asymmetric allenylic alkylation.
Reversible tri-state structural transitions of hybrid copper(i) bromides toward tunable multiple emissions
Authors: Wu Jiajing , Qi Jing-Li , Guo Yue , Yan Shufang , Liu Wenlong , Guo Sheng-Ping
Published: October 2023

Synthetic control and tri-state structural transitions (112 ↔ 224 ↔ 246) of three hybrid copper bromides with different coordination geometries, which exhibit tunable optical property, are fristly discovered and investigated in hybrid copper halides.
Adaptive mixed variable Bayesian self-optimisation of catalytic reactions
Authors: Aldulaijan Naser , Marsden Joe A. , Manson Jamie A. , Clayton Adam D.
Published: October 2023

A novel adaptive latent Bayesian optimisation (ALaBO) algorithm accelerates the development of mixed variable catalytic reactions.
An emissive charge-transfer excited-state at the well-defined hetero-nanostructure interface of an organic conjugated molecule and two-dimensional inorganic nanosheet
Authors: Umeyama Tomokazu , Mizutani Daizu , Ikeda Yuki , Osterloh W. Ryan , Yamamoto Futa , Kato Kosaku , Yamakata Akira , Higashi Masahiro , Urakami Takumi , Sato Hirofumi , Imahori Hiroshi
Published: October 2023

An unusual emissive charge-transfer excited state was formed at the pyrene–MoS2 interface.
A dual-responsive ratiometric indicator designed for in vivo monitoring of oxidative stress and antioxidant capacity
Authors: Yang Majun , Zhu Weida , Lv Yilin , Jiang Bin , Jiang Chenxia , Zhou Xiaobo , Li Guo , Qin Yuling , Wang Qi , Chen Ziwei , Wu Li
Published: October 2023

A novel H2O2 and NAD(P)H indicator for in vivo monitoring oxidative stress and antioxidant capacity in the model of acute myocardial infarction and trichloroethylene exposure has been reported.
Water sensitivity of heteroepitaxial Cu-MOF films: dissolution and re-crystallization of 3D-oriented MOF superstructures
Authors: Brandner Lea A. , Linares-Moreau Mercedes , Zhou Guojun , Amenitsch Heinz , Dal Zilio Simone , Huang Zhehao , Doonan Christian , Falcaro Paolo
Published: October 2023

We report the effect of humidity on oriented Cu-MOF films, including the epitaxial transformation of 3D-oriented Cu2(BDC)2DABCO into 3D-oriented Cu2(BDC)2.
Dual-responsive colloidosome-like microgels as the building blocks for phase inversion of Pickering emulsions
Authors: Jiang Hang , Fang En , Qi Lin , Guan Xin , Li Yunxing , Liu Wei , Ngai To
Published: October 2023

Dual-responsive soft colloidal particles with adjustable hydrophilic and hydrophobic properties can be achieved Pickering emulsion phase inversion.
Elucidating multiple reaction pathways for the degradation of antibiotics in water by a self-active single-atom zinc catalyst on biochar
Authors: Yuan Jieming , Han Yunkyoung , Sathiyan Krishnamoorthy , Sharma Virender K. , Mokarizadeh Abdol Hadi , Tsige Mesfin , Jiang Jiechao , Ma Xingmao
Published: October 2023

Single-atom catalysts (SACs) have gained notable attention for the degradation of organic contaminants in water.
A multimodal PDMS triboelectric nanogenerator sensor based on anodised aluminium oxide template preparation for object recognition
Authors: Zhu Hongde , Liang Junlan , Wang Sanlong , Huang Junjun , Chen Zhenming
Published: October 2023

With triboelectric nanogenerators (TENGs) increasingly being used as touch sensors, their recognition accuracy is critical for the practical application of TENG devices.
Superelastic, highly conductive, and superhydrophobic silver nanowires@polypyrrole hybrid aerogels with outstanding electromagnetic interference shielding and Joule heating performance
Authors: Peng Fei , Zhu Wenbo , Fu Bicheng , Fang Yi , Peng Zhipeng , He Jingjing , Chen Hongtao , Ji Hongjun , Hang Chunjin , Li Mingyu
Published: October 2023

AgNW@PPy hybrid aerogels made by one-step hydrothermal methods and in situ chemical polymerization. The gels resist interfacial slip when compressed, with channels for electron conduction. Exhibiting excellent compressible elasticity, EMI shielding, and low-voltage-driven Joule heating performance.
A wet-resistant and low-temperature self-healing organohydrogel sensor towards direction-recognition and information transmission in extreme environments
Authors: Feng Enke , Li Xiaoqin , Zhang Mengzhen , Li Ying , Wang Dailian
Published: October 2023

A superior self-healing organohydrogel with multi-environmental stability for direction-recognition and information transmission under humid environments and low-temperature conditions.
Correction: Ternary alloyed MoS2−xSex nanocomposites with a carrier mobility-dominated gas sensing mode: a superior room temperature gas sensing material for NO2 sensors
Authors: Yin Mingli , Wang Kexin , Zhang Liaochuan , Gao Chunxiao , Ren Juan , Yu Lingmin
Published: October 2023

Correction for ‘Ternary alloyed MoS2−xSex nanocomposites with a carrier mobility-dominated gas sensing mode: a superior room temperature gas sensing material for NO2 sensors’ by Mingli Yin et al., J. Mater. Chem. C, 2023, 11, 9715–9726, https://doi.org/10.1039/D3TC01551C.
Mapping lipid pathways during phagocytosis
Authors: Saharan Ojal , Kamat Siddhesh S.
Published: October 2023

Phagocytosis is an evolutionarily conserved important immunological process in higher organisms, and acts as the first line of defense against invading pathogenic microbial infections. Additionally, this dynamic innate immune response is also critical for clearing apoptotic cells and/or tissues, is responsible for maintaining homeostasis and acts as a systemic regulator of critical physiological processes such as wound healing and tissue regeneration. Over the past two decades, numerous studies have shown that phagocytosis occurs in three spatiotemporally distinct steps, namely formation, maturation and resolution of the phagosome, and that, both the protein and lipid composition change as a function of the aforementioned steps during this immunological process. While significant knowledge is now available on the proteomic content of a phagosome during the different stages of phagocytosis, the lipidome however, remained lesser explored, until the past few years. In this review, we summarize recent efforts towards mapping the physiological roles and functions of three lipid classes, the phosphatidylinositols, cholesterol and sphingolipids during the various stages of phagocytosis, and discuss strategies evolved by microbes to hijack and/or disrupt these lipid pathways to evade the immune system. We conclude this review with some potential avenues that may be pursued towards mapping hitherto unknown lipid pathways during phagocytosis, and how this research might be beneficial in our ongoing battle to overcome pathogenic infections.
Numerical thermal analysis of synchronous reluctance generator for wind energy application
Authors: Tolesa Tefera Kitaba , Tripathy Praveen , Adda Ravindranath
Published: October 2023

This paper focuses on the thermal analysis of the synchronous reluctance generator with a rating of 2.1 kW. It mainly uses explicit, and implicit finite difference methods for thermal analysis to reduce the complexity of thermal calculation for the machine's components. It compares the results with the results obtained using a finite element analysis (FEA) and includes the experimental verification of the obtained results. The explicit, and implicit finite difference thermal analysis is relatively simple and computationally fast. Once the design parameters are known, the electric losses and iron losses of the synchronous reluctance generator are evaluated. These machine parameters are utilized in developing the explicit finite difference (EFD), an implicit finite difference (IFD), and a 3D FEA model for thermal analysis. It is observed that the obtained results from the EFD, IFD, FEA, and experiments are very close to each other, and the temperature rise for the designed machine is within the desired and acceptable range.
The CARMENES search for exoplanets around M dwarfs
Authors: Nagel E. , Czesla S. , Kaminski A. , Zechmeister M. , Tal-Or L. , Schmitt J. H. M. M. , Reiners A. , Quirrenbach A. , García López A. , Caballero J. A. , Ribas I. , Amado P. J. , Béjar V. J. S. , Cortés-Contreras M. , Dreizler S. , Hatzes A. P. , Henning Th. , Jeffers S. V. , Kürster M. , Lafarga M. , López-Puertas M. , Montes D. , Morales J. C. , Pedraz S. , Schweitzer A.
Published: October 2023

Light from celestial objects interacts with the molecules of the Earth’s atmosphere, resulting in the production of telluric absorption lines in ground-based spectral data. Correcting for these lines, which strongly affect red and infrared wavelengths, is often needed in a wide variety of scientific applications. Here, we present the template division telluric modeling (TDTM) technique, a method for accurately removing telluric absorption lines in stars that exhibit numerous intrinsic features. Based on the Earth’s barycentric motion throughout the year, our approach is suited for disentangling telluric and stellar spectral components. By fitting a synthetic transmission model, telluric-free spectra are derived. We demonstrate the performance of the TDTM technique in correcting telluric contamination using a high-resolution optical spectral time series of the feature-rich M3.0 dwarf star Wolf 294 that was obtained with the CARMENES spectrograph. We apply the TDTM approach to the CARMENES survey sample, which consists of 382 targets encompassing 22 357 optical and 20 314 near-infrared spectra, to correct for telluric absorption. The corrected spectra are coadded to construct template spectra for each of our targets. This library of telluric-free, high signal-to-noise ratio, high-resolution (ℛ > 80 000) templates comprises the most comprehensive collection of spectral M-dwarf data available to date, both in terms of quantity and quality, and is available at the project website.
Composition of giant planets: The roles of pebbles and planetesimals
Authors: Danti C. , Bitsch B. , Mah J.
Published: October 2023

One of the current challenges of planet formation theory is to explain the enrichment of observed exoplanetary atmospheres. While past studies have focused on scenarios where either pebbles or planetesimals are the main drivers of heavy element enrichment, here we combine the two approaches to understand whether the composition of a planet can constrain its formation pathway. We study three different formation scenarios: pebble accretion, pebble accretion with planetesimal formation inside the disc, and combined pebble and planetesimal accretion. We used the CHEMCOMP code to perform semi-analytical 1D simulations of protoplanetary discs, including viscous evolution, pebble drift, and simple chemistry to simulate the growth of planets from planetary embryos to gas giants as they migrate through the disc, while simultaneously tracking their composition. Our simulations confirm that the composition of the planetary atmosphere is dominated by the accretion of gas vapour enriched by inward-drifting and evaporating pebbles. Including planetesimal formation hinders this enrichment because many pebbles are locked into planetesimals and cannot evaporate and enrich the disc. This results in a dramatic drop in accreted heavy elements in the cases of planetesimal formation and accretion, demonstrating that planetesimal formation needs to be inefficient in order to explain planets with high heavy element content. On the other hand, accretion of planetesimals enhances the refractory component of the atmosphere, leading to low volatile-to-refractory ratios in the atmosphere, in contrast to the majority of pure pebble simulations. However, low volatile-to-refractory ratios can also be achieved in the pure pebble accretion scenario if the planet migrates all the way into the inner disc and accretes gas that is enriched in evaporated refractories. Distinguishing these two scenarios requires knowledge about the planet’s atmospheric C/H and O/H ratios, which are much higher in the pure pebble scenario compared to the planetesimal formation and accretion scenario. This implies that a detailed knowledge of the composition of planetary atmospheres could help to distinguish between the different formation scenarios.
Impact of organic particles from wafer handling equipment on silicon heterojunction pseudo-efficiency
Authors: Fischer Andreas , Vulcanean Ioan Voicu , Pingel Sebastian , Steinmetz Anamaria
Published: October 2023

Within this paper a systematic analysis of particle transfer onto SHJ Solar cell precursors by handling with suction cups and the impact on the pseudo efficiency is presented. The study establishes a correlation between particle area coverage and a resulting loss of pseudo solar cell parameters. The analysis was carried out on one hand by means of SEM measurements at the contact points between suction cup and wafer to quantify particle transfer and on the other hand by means of suns photoluminescence imaging measurements to evaluate the resulting losses. It is shown that the choice of contact material and the wafer temperature have a significant influence on the transferred particle number, their size and the resulting particle area coverage. A local electrical defect was observed at these particle-rich spots, which also affected a larger area around this insufficiently passivated region. This had a significant negative effect on the pseudo efficiency, which is more pronounced for increasing particle area coverage. If the particle density is increased by 0.1% within an area of 800 mm2, the pseudo efficiency in this area decreases by almost 1.2%Relative. The correlation found can be used to predict an efficiency loss using standard photoluminescence images.
Effects of two subtropical piscivorous fish species on sediment disturbance and water quality: Implication for restoration by stocking piscivores
Authors: Qian Tian , He Hu , Li Kuanyi , Yue Chunlei , Jeppesen Erik
Published: October 2023

Subtropical lakes are often dominated by benthi-omnivorous fish (e.g., crucian carp) that may substantially disturb sediments and thereby increase water turbidity and nutrient concentrations. Piscivores stocking is sometimes used to control these benthi-omnivores in the expectation that they will reduce their adverse effects on the water quality. However, in shallow subtropical lakes the benthic foraging activities of piscivorous fish may also disturb sediments, a topic that has not yet been well elucidated. Here, we conducted a 6-day mesocosm experiment to explore the bioturbation effects of two native subtropical piscivorous fish (i.e., snakehead,Channa argusand mandarin fish,Siniperca chuatsi) in prey fish (crucian carp,Carassius carassius) present and absent scenarios. Our results showed that in mesocosms without prey, both snakehead and mandarin fish greatly increased the concentrations of suspended solids. However, the concentrations of total, organic and inorganic suspended solids were significantly higher in the mesocosms with snakehead than in those with mandarin fish, suggesting that snakehead has higher bioturbation effects than mandarin fish. When crucian carp were present, we found that both snakehead and mandarin fish significantly reduced prey abundance, whereas piscivore stocking did not significantly decrease the suspended solids and nutrient concentrations. Our study revealed differential effects of two subtropical piscivorous fish species on sediment disturbance and water quality, and we suggest that for lake restoration with piscivores stocking, mandarin fish are a better option than snakehead fish as their predation effect was equal but the strength of sediment disturbance by mandarin fish was lower than that of snakehead.
Optimal friction matrix for underdamped Langevin sampling
Authors: Chak Martin , Kantas Nikolas , Lelièvre Tony , Pavliotis Grigorios A.
Published: October 2023

We propose a procedure for optimising the friction matrix of underdamped Langevin dynamics when used for continuous time Markov Chain Monte Carlo. Starting from a central limit theorem for the ergodic average, we present a new expression of the gradient of the asymptotic variance with respect to friction matrix. In addition, we present an approximation method that uses simulations of the associated first variation/tangent process. Our algorithm is applied to a variety of numerical examples such as toy problems with tractable asymptotic variance, diffusion bridge sampling and Bayesian inference problems for high dimensional logistic regression.
ICD-11 zwischen Entwicklung und Implementierung
Authors: Gaebel Wolfgang
Published: October 2023

Zum 1. Januar 2022 hat die WHO den Beginn des weltweiten Umstiegs von ICD-10 auf
ICD-11 für die Berichterstattung zur Todesursachenstatistik anhand der neuen
Mortality and Morbidity Statistics (MMS) festgesetzt und flexibel auf
zunächst 5 Jahre terminiert.
Druckulkus unter Kompressionstherapie bei Neuropathie und arteriellem Verschluss
Authors: Stegemann Jana , Miller Anya
Published: October 2023

Wir berichten über eine Patientin, die infolge der Komplexen Physikalischen Entstauungstherapie (KPE) ein Ulkus mit Osteomyelitis am Fuß entwickelte.

Zur Behandlung eines iatrogenen Lymphödems im Stadium II am linken Unterschenkel und Fuß wurde eine Phase-1-Behandlung (Entstauungsphase) mit täglicher manueller Lymphdrainage (MLD) und Kompressionsbandagierung eingeleitet. Im Verlauf bildete sich ein Ulkus am lateralen Fußrand.

Bei Zustand nach Resektion, Polychemotherapie und Radiatio eines Synovialsarkoms der linken Kniekehle vor 22 Jahren, sowie Rekonstruktion der A. poplitea bestand eine Polyneuropathie, weshalb ein Verschluss der A. poplitea bis zu diesem Zeitpunkt symptomlos blieb.

Der durch die leitliniengerechte Kompressionsbandagierung und -bestrumpfung erhöhte Druck im linken Fuß führte im Zusammenhang mit der Minderperfusion des Gewebes zur Entstehung eines infizierten Druckulkus mit Osteomyelitis.

Durch interventionelle Rekanalisation des arteriellen Stroms, lokale chirurgische Sanierung mit Teilamputation des Os Metatasale V und systemische Antibiose wurde eine Heilung des Ulkus erreicht.
Evaluation Of The Relationship Of Kinesiophobia With Anxiety, Upper
Extremity Disability And Quality Of Life In Patients With Frozen
Shoulders
Authors: Batmaz öznur Uysal , Yakar Burkay , Mirzaoğlu Tacettin , Yılmaz Ahmet , Em Serda , Batmaz Ibrahim
Published: October 2023

Introduction Frozen shoulder is a painful shoulder disease in which
glenohumeral joint movements are actively and passively restricted in all
directions. If not treated, it can cause various psychological diseases and
muscle and joint diseases. Kinesiophobia; this is defined as a fear of physical
activity resulting from excessive sensitivity and an uncomfortable feeling due
to painful or repeated injury. In this study, it was aimed to evaluate the
relationship of kinesiophobia to upper extremity disability, anxiety and quality
of life in patients with frozen shoulder.

Materials and methods Fırat University Faculty of Medicine,
Department of Physical Medicine and Rehabilitation, between September 2020 and
March 2021; As a result of clinical evaluation and radiological examinations,
patients were enrolled between the ages of 18–75 and who agreed to
participate in the study; 48 patients were diagnosed with frozen shoulder and
met the inclusion and exclusion criteria of the study and were included in the
patient group; Fourty healthy subjects aged between 18–75 years, who did
not have shoulder disease and who met the inclusion and exclusion criteria of
the study, were included in the control group. A total of 88 cases were included
in the study. The following scales were used. TAMPA kinesiophobia scale to
assess kinesiophobia in patients and control group, Beck Anxiety scale to assess
anxiety in patient group; The Disabilities of The Arm, Shoulder and Hand (DASH)
scale to assess upper extremity disability; Short Form (SF)-36 was used to
assess quality of life.

Results TAMPA kinesiophobia scale was found to be significantly different
in the patient group when the patient group and control group were compared.
According to the correlation analysis, the TAMPA kinesiophobia scale showed a
positive correlation with the Beck-Anxiety and DASH scales in the patient group,
while a negative correlation was found with the SF36-Physical function,
emotional role difficulty and social functionality.

Conclusion In patients with frozen shoulder, kinesiophobia seems to be
associated with increased anxiety and upper extremity disability, as well as low
quality of life. Structural disorders as well as psychological factors should be
taken into account among the reasons for the prolonged limitation of movement
and delayed recovery. When the physicians serving in the primary care are
experienced with patient management with frozen shoulder, as evaluated for
therapeutic purposes, planning psychological support treatments in addition to
medical and physical therapy will increase the quality of health care provided
to patients.
Die späte offene Semikonversion mit Prothesenerhalt bei (Typ II­)Endoleckagen mit spätem Aneurysmasackwachstum nach EVAR - Indikationen, Methode und Ergebnisse im eigenen Patientenkollektiv
Authors: Walensi Mikolaj , Krasniuk Iuri , Tsilimparis Nikolaos , Hoffmann Johannes N.
Published: October 2023

Die EVAR (englisch: Endovascular Aortic Repair) ist inzwischen die häufigste Methode zur
Ausschaltung eines Bauchaortenaneurysmas, birgt jedoch prinzipiell und – nach neusten
Erkenntnissen klinisch bestätigt – die Gefahr später auftretender Komplikationen. Diese
können u. a. durch ein (spätes) Aneurysmasackwachstum entstehen. Sind konservative und
interventionelle Therapiemaßnahmen diesbezüglich ausgeschöpft, so ist eine offene Konversion
vonnöten, um einer Aneurysmaruptur vorzubeugen. Hierzu stehen mehrere Verfahren zur
Verfügung, bei denen die EVAR-Prothese komplett erhalten werden kann oder (partiell)
entfernt wird. Die späte offene Semikonversion mit In-situ-Erhalt der EVAR-Prothese und
Raffung des Aneurysmasacks kann für den Patienten im Vergleich zur vollständigen Konversion
eine weniger belastende Operationsmethode darstellen. Ziel der vorliegenden Arbeit ist die
Darstellung der Operationsmethode samt Indikationen und technischen Hinweisen sowie die
Präsentation der Ergebnisse im rezenten klinikeigenen Patientenkollektiv.

Alle Patienten, die in unserer Klinik für Gefäßchirurgie und Phlebologie aufgrund einer
(Typ-II-)Endoleckage semikonvertiert wurden, wurden eingeschlossen. Alle Daten werden als n
(%) bzw. Median (Spannweite) angegeben.

Zwischen 6/2019 und 3/2023 wurde bei 13 Patienten eine Semikonversion durchgeführt.
Diese fand 6 (2–12) Jahre (Median, Spannweite) nach der initialen EVAR statt, der
Aneurysmasackdurchmesser lag zum Zeitpunkt der Semikonversion bei 69 mm (58–95 mm). Die
Operationszeit lag bei 114 min (97–147 min), der Blutverlust bei 100 ml (100–1500 ml). Fünf
(38%) Patienten erhielten intraoperativ, 2 (15%) postoperativ Bluttransfusionen. Der
Aufenthalt auf der Intensivstation dauerte 1 (1–5) Tage, die Hospitalisationszeit betrug 8
(6–11) Tage. Postoperative Komplikationen waren Darmatonie (3 [23%], 1 [8%] mit
Nausea/Emesis und Magensondeneinlage), Anämie (2 [15%]), Hyponatriämie (2 [15%]), Delir (1
[8%]), COVID-19-Infektion (1 [8%]) sowie 1 [8%] intraabdominelle Nachblutung mit der
Indikation zur operativen Revision und der Transfusion von 8 EKs.

Die Semikonversion ist eine sicher durchführbare und mit weniger schweren Komplikationen
behaftete Operationsmethode für ein ausgewähltes Patientenkollektiv und sollte als
Alternative zu invasiveren Methoden mit (partieller) Prothesenentfernung in Betracht gezogen
werden. Weitere Untersuchungen zum Vergleich der Semikonversion mit der vollen Konversion
sind im Langzeitverlauf notwendig um ihre Vorteile zu belegen.
Factors Associated with Antidepressant Effects of Ketamine: A
Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous
Ketamine for Treatment-Resistant Depression
Authors: Yonezawa Kengo , Uchida Hiroyuki , Yatomi Taisuke , Ohtani Yohei , Nomoto-Takahashi Kie , Nakajima Shinichiro , Mimura Masaru , Tani Hideaki
Published: October 2023

Introduction Predictors of treatment response to intravenous ketamine
remain unclear in patients with treatment-resistant depression (TRD); therefore,
this study aimed to clarify these predictors using the US National Institutes of
Health database of clinical trials.

Methods Data from a placebo-controlled, double-blind, randomized
controlled trial were used to assess the efficacy of intravenous ketamine in
adult patients with TRD (NCT01920555). For the analysis, data were used from the
participants who had received therapeutic doses of intravenous ketamine
(i. e., 0.5 and 1.0 mg/kg). Logistic and multivariable
regression analyses were conducted to explore the demographic and clinical
factors associated with response to treatment or changes in the Hamilton
Depression Rating Scale 6 items (HAM-D-6) total score.

Results This study included 31 patients with TRD (13 women;
mean±standard deviation age, 48.4±10.9 years). Logistic
regression analysis showed that the age of onset was positively correlated with
treatment response after three days of ketamine administration
(β=0.08, p=0.037); however, no association was observed
between treatment response and age, sex, baseline HAM-D-6 total score, or
dissociative score assessed with the Clinician-Administered Dissociative States
Scale 40 min after ketamine infusion. Multiple regression analysis showed that
no factors were correlated significantly with the percentage change in the
HAM-D-6 total score three days after ketamine administration.

Discussion Later disease onset correlates with a better treatment response
three days after ketamine infusion in patients with TRD. Glutamatergic signal
transmission may be impaired in patients with an earlier onset of depression,
resulting in decreased neuroplasticity, which diminishes ketamine response.
Sargachromenol Attenuates Inflammatory Responses by Regulating NF-κB and Nrf2 Pathways in RAW 264.7 Cells and LPS-treated Mice
Authors: Joung Eun-Ji , Lee Min-Kyeong , Lee Minsup , Gwon Misung , Shin Taisun , Ryu Heeyeon , Jeong Hyeon Hak , Kim Myeong-Jin , Van Ji Yun , Kim Jae-Il , Choi Jinkyung , Jung Won-Kyo , Kim Hyeung-Rak , Lee Bonggi
Published: October 2023

This study aims to explore the anti-inflammatory mechanisms of sargachromenol in both RAW 264.7 cells and lipopolysaccharide (LPS)-treated mice, as previous reports have suggested that sargachromenol possesses anti-aging, anti-inflammatory, antioxidant, and neuroprotective properties. Although the precise mechanism behind its anti-inflammatory activity remains unclear, pretreatment with sargachromenol effectively reduced the production of nitric oxide, prostaglandin E2, and interleukin (IL)-1β in LPS-stimulated RAW 264.7 cells by inhibiting cyclooxygenase-2. Moreover, sargachromenol inhibited the activation of nuclear factor-κB (NF-κB) by preventing the degradation of the inhibitor of κB-α (IκB-α) and inhibiting protein kinase B (Akt) phosphorylation in LPS-stimulated cells. We also found that sargachromenol induced the production of heme oxygenase-1 (HO-1) by activating the nuclear transcription factor erythroid-2-related factor 2 (Nrf2). In LPS-treated mice, oral administration of sargachromenol effectively reduced the levels of IL-1β, IL-6, and tumor necrosis factor-α (TNF-α) in the serum, suggesting its ability to suppress the production of inflammatory mediators by inhibiting the Akt/NF-κB pathway and upregulating the Nrf2/HO-1 pathway.
Investigation of Anti-SARS-CoV-2-specific IgG Levels in Breast Milk after Vaccination or COVID-19 Infection
Authors: Temocin Fatih , Çaycı Yeliz Tanrıverdi , Seren Canan , Kuruoglu Tuba , Atilla Aynur , Birinci Asuman , Tanyel Esra
Published: October 2023

Objective Newborns are vulnerable to all types of infections due to their developing immune system. To compensate for their immune immaturity, newborns rely on the passive transfer of antibodies through the placenta and own mother's breast milk (BM). In the present study, we investigated whether vaccination against SARS-CoV-2 leads to the presence of antibodies in BM. Furthermore, we compared the levels of SARS-CoV-2-specific anti-spike (anti-S) IgG antibodies in the BM of mothers who were vaccinated against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or had coronavirus disease 2019 (COVID-19) infection naturally or were vaccinated after natural infection.

Study Design This was a prospective cohort study conducted in the Ondokuz Mayis University Faculty of Medicine. Forty-six mothers who had at least two doses of the BNT162b2 messenger RNA-based vaccine and/or had a history of symptomatic COVID-19 infection were included in the study. BM samples were analyzed by the Abbott Architect SARS-CoV-2 IgG II Quant kit following the manufacturer's instructions.

Results Forty-six mothers with an average age of 29.7 ± 5.7 years participated the study: 18 (39.1%) had COVID-19 infection + BTN162b2 vaccine, 17 (37.0%) had BTN162b2 vaccine, and 11 (23.9%) had natural infection. The highest SARS-CoV-2-specific anti-S IgG antibody titers in BM were found in mothers who were vaccinated following the infection (anti-SARS-CoV-2 IgG: 32.48 ± 57.1 arbitrary units AU/mL). However, no significant difference in anti-SARS-CoV-2 antibody levels was observed between the three groups (p = 0.641). No antibody was detected in 15.2% of BM samples.

Conclusion Both vaccination and natural COVID-19 infection during pregnancy leads to the passive transfer of specific anti-SARS-CoV-2 IgG antibodies to BM. These results are important to overcome vaccine hesitancy and increase vaccination levels in expectant mothers.

Key Points
Bone Fracture-healing Properties and UPLC-MS Analysis of an Enriched Flavonoid Fraction from Oxystelma esculentum
Authors: Rawat Priyanka , Sharma Kriti , Khanka Sonu , Singh Yatendra , Prakash Ravi , Rais Nisha , Maurya Arvind Kumar , Gupta Ritika , Mishra Dipak K. , Singh Divya , Kanojiya Sanjeev
Published: October 2023

Oxystelma esculentum has been used as a folk medicine to treat jaundice, throat infections, and skin problems. In the current study, the bone fracture-healing properties of a
flavonoid-enriched fraction (Oxy50-60F) of O. esculentum were investigated in Swiss mice using a drill-hole injury model. Oxy50-60F (1 mg/kg/day, 5 mg/kg/day, and 10 mg/kg/day) was
administered orally (from the next day) after a 0.6 mm drill-hole injury in mice femur mid-diaphysis for 7 days and 14 days. Parathyroid hormone (40 µg/kg; 5 times/week) was given
subcutaneously as the positive control. Confocal imaging for bone regeneration, micro-architecture of femur bones, ex vivo mineralization, hematoxyline and eosin staining, measurement
of reactive oxygen species, and gene expression of osteogenic and anti-inflammatory genes were studied. Quercetin, kaempferol, and isorhamnetin glycosides were identified in the active
fraction using mass spectrometry techniques. Our results confirm that Oxy50-60F treatment promotes fracture healing and callus formation at drill-hole sites and stimulates osteogenic and
anti-inflammatory genes. Oxy50-60F administration to fractured mice exhibited significantly better micro-CT parameters in a dose-dependent manner and promoted nodule mineralization at days 7
and 14 post-injury. Oxy50-60F also prevents ROS generation by increasing expression of the SOD2 enzyme. Overall, this study reveals that Oxy50-60F has bone regeneration potential in a
cortical bone defect model, which supports its use in delayed-union and non-union fracture cases.
Identification of Major Bioactive Anti-inflammatory Compounds of Derris scandens Stem Using RAW 264.7 Cells and HPLC-UV Analysis
Authors: Sae-Foo Worapol , Yusakul Gorawit , Nualkaew Natsajee , Putalun Waraporn
Published: October 2023

Derris scandens (DS) is widely recognized for its therapeutic properties, specifically its analgesic effects, which significantly alleviate muscle pain. The chemical constituents of
DS stem include various isoflavone derivatives. However, there is currently a lack of specified anti-inflammatory chemical markers and analytical methods for quality control. The present
study aimed to evaluate the anti-inflammatory activity of DS and its constituents using the RAW 264.7 cell model. The expression of inflammatory genes such as inducible nitric oxide synthase
(iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and 5-lipoxygenase (5-LOX) was examined using quantitative RT-PCR. An high-performance liquid chromatography with a UV detection
method was developed to quantitatively analyze genistein-7-O-[α-rhamnopyranosyl-(1 → 6)]-β-glucopyranoside, genistein, derrisisoflavone A, lupalbigenin, and
6,8-diprenylgenistein in DS stem. The developed HPLC-UV method demonstrated high sensitivity with limits of detection and quantification ranging from 0.01 to 0.06 µg/mL and 0.03 to
0.18 µg/mL, respectively. The accuracy of the method ranged from 93.3 to 109.6%. Furthermore, the repeatability and reproducibility of the method were suitable, as indicated by the relative
standard deviations of ≤ 3.02% and ≤ 6.22%, respectively. The DS extract notably inhibited NO production, exhibiting effects comparable to those of 500 µM diclofenac, and substantially
suppressed the expression of iNOS, COX-2, IL-6, and 5-LOX of lipopolysaccharide (LPS)-induced genes. As to the pure isoflavone derivatives, the order of NO production inhibition was found to
be genistein > lupalbigenin > derrisisoflavone A > 6,8-diprenylgenistein > genistein-7-O-[α-rhamnopyranosyl-(1 → 6)]-β-glucopyranoside. Genistein,
derrisisoflavone A, and 6,8-diprenylgenistein significantly suppressed the upregulation of all LPS-induced genes. Consequently, these compounds are recommended as anti-inflammatory markers
for the quantitative chemical analysis of DS.
Ring Transformation of Annulated Benzofuran Derivatives to Medium-Sized Lactones
Authors: Christoffers Jens , Fliegel Lukas , Krauß Julian
Published: October 2023

Benzannulated eight- and nine-membered-ring lactones were prepared by ring transformation of annulated benzofuran derivatives. The reaction sequence starts with a Brønsted acid catalyzed hydration of the enol ether moiety of the starting materials furnishing hemiacetals as intermediate products which underwent retro-Claisen-type C–C bond cleavage under the reaction conditions. The use of 15 mol% TfOH and two equivalents of water in CHCl3 at 85 °C turned out to be optimal. Products with exocyclic carboxylate function could be further derivatized by amide formation. In total, eleven medium-sized lactones were prepared. Furthermore, three benzannulated spirolactones were obtained from starting materials with exocyclic carboxamide moiety.
Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki–Miyaura Cross-Coupling
Authors: Bizet Vincent , Rummler Lénaic , Sater Mariam Abd El , Blanchard Nicolas
Published: October 2023

Alkenylboranes are key intermediates in modern organic synthesis, and they are usually obtained by the borylation of alkynes. We report herein highly regio- and stereoselective syntheses of α,Z- and β,Z-trifluoromethylated alkenylboranes by copper-catalyzed borylation reactions. Further functionalizations by palladium-catalyzed Suzuki–Miyaura cross-couplings have been developed and, interestingly, a marked difference in reactivity between the α- and β-borylated isomers has been identified.
Quinolinamide-Enabled Nickel-Catalyzed Regio- and Diastereoselective γ,δ-Arylalkylation of Nonactivated Alkenes
Authors: Wang Chao , Zhang Lanlan , Zhao Lei , Zhu Yuqin
Published: October 2023

A quinolinamide-enabled nickel-catalyzed γ,δ-arylalkylation of homoallylic amines with aryl iodides and organozinc compounds has been developed. The cleavable quinolinamide directing group facilitates the stabilization of a five-membered nickelacycle, and enables the dicarbofunctionalization of nonactivated alkenes with excellently regio-, chemo-, and diastereoselectivity. The reaction with internal alkenes proceeds stereospecifically to provide valuable γ-alkyl-δ-aryl-substituted amines with two vicinal stereocenters. The scope of substrates and the utility of the protocol have been thoroughly studied.
The Variability of the Components of Fitness along the Menstrual
Cycle
Authors: Ruiz-Alias Santiago A. , Pérez-Castilla Alejandro , Marcos-Blanco Aitor , Moreno-Ortega Claudia , Fernández-Navarrete Iván , García-Pinillos Felipe
Published: October 2023

This study aims to determine the variability of the components of fitness along
the menstrual cycle (MC) of physically active eumenorrheic women. Fifteen
subjects were monitored along two consecutive MCs through the calendar-based
counting method in combination with a urine luteinizing hormone surge kit.
Subjects were tested at the early follicular phase (EFP), pre-ovulatory or late
follicular phase (LFP), and post-ovulatory or mid-luteal phase (MLP). In each
session, the back squat one-repetition maximum (1-RM), maximum fat oxidation
(MFO), maximum oxygen uptake (VO2max) and acute recovery capacity
were determined. The results revealed a wide variability among components of
fitness and a low to high variability among subjects (acute recovery: 3.6%
[range 1.5 to 9.5%]; back squat 1-RM: 6.1% [range 2.2 to 11%];
VO2max: 6.6% [range 1.1 to 15%]; MFO: 23% [range 4.6 to 35%]).
Despite the individual nature, considering the number and magnitude of the
responses in each MC phase, VO2max and acute recovery capacity tended
to be enhanced at the LFP, the MFO at the MLP, and the back squat 1-RM remained
stable along the MC. Thus, practitioners are aware of which components are
susceptible to change along the MC phase, but an individual monitoring is
recommended.
Lewis Base/3d Transition-Metal Cooperatively Catalyzed Asymmetric Reactions
Authors: Gong Liu-Zhu , Song Jin
Published: October 2023

Lewis base/transition-metal cooperatively catalyzed asymmetric transformations have attracted extensive attention as they offer complementary catalytic systems within the realm of cooperative catalysis. Recently, the synergistic use of Lewis bases in combination with earth-abundant 3d metals has emerged as a fascinating prospect, presenting an opportunity to move away from the reliance on noble metals and to explore novel catalytic processes. In this Account, we highlight our recent achievements regarding the chemistry and synthetic utility of isothiourea (ITU) activated C1-ammonium enolates and N-heterocyclic carbene (NHC)-bound homoenolate equivalents in conjunction with 3d transition-metal activated electrophiles. The remarkable success in the stereoselective construction of carbon–carbon and carbon–heteroatom bonds has led to significant contributions to stereodivergent synthesis.

1 Introduction

2 ITU/Copper Cooperative Catalysis

3 NHC/Copper Cooperative Catalysis

4 NHC/Nickel Cooperative Catalysis

5 Conclusion
Effect of a novel endoscope cleaning brush on duodenoscope contamination
Authors: Bruno Marco J. , Severin Juliëtte A. , van der Ploeg Koen , Haanappel Cynthia P. , Voor in ’t holt Anne F. , de Groot Woutrinus , Bulkmans Adriana J.C. , Erler Nicole S. , Mason-Slingerland Bibi C.G.C. , Vos Margreet C.
Published: October 2023

Background Current duodenoscope reprocessing protocols are
insufficient to prevent contamination and require adaptations to prevent endoscopy-associated
infections (EAIs). This study aimed to investigate the effect of a new endoscope cleaning
brush on the contamination rate of ready-to-use duodenoscopes.

Methods This retrospective before-and-after intervention study
collected duodenoscope surveillance culture results from March 2018 to June 2022.
Contamination was defined as ≥1 colony-forming unit of a microorganism of gut or oral origin
(MGO). In December 2020, an endoscope cleaning brush with a sweeper design was introduced as
an intervention in the manual cleaning of duodenoscopes. A logistic mixed-effects model was
used to study the effects of this intervention.

Results Data were collected from 176 culture sets before the new brush’s introduction and 81 culture sets afterwards. Pre-introduction, culture sets positive with an MGO comprised 45.5% (95%CI 38.3%–52.8%; 80/176), decreasing to 17.3% (95%CI 10.6%–26.9%; 14/81) after implementation of the new brush. Compared with the former brush, duodenoscopes cleaned with the new brush had lower odds of contamination with MGOs (adjusted odds ratio 0.25, 95%CI 0.11–0.58; P=0.001)

Conclusions Use of the new brush in manual cleaning reduced contamination with MGOs and is expected to prevent EAIs. These findings should be confirmed in future prospective randomized studies.
An Efficient Copper-Mediated Route for the Synthesis of 2-Substituted Benzothiazoles from Dithioesters and Investigation of Their Antibacterial Activities
Authors: Sadashiva Maralinganadoddi P. , Sukrutha Kodipura P. , Kiran Kuppalli R. , Gunashree Kodagahally T. , Divyashree Shivakumar , Purusotham Prerana , Sreenivasa Marikunte Y.
Published: October 2023

An efficient one-pot synthesis of 2-aryl/2-aroylbenzothiazoles through copper-mediated condensation of 2-chloroanilines with dithioesters has been developed. The method provides good isolated yields and exhibits broad functional group tolerance, accommodating both electron-donating and electron-withdrawing groups on the substrates. A series of synthesized compounds was evaluated for their antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella paratyphi. Among the series, three compounds exhibited a significant inhibitory effect against the tested pathogens, with one also demonstrating potential as an effective compound in both the agar well diffusion assay and broth microdilution assay. Additionally, the three compounds displayed strong inhibitory effects on biofilm formation of the pathogens in both the crystal violet assay and MTT assay at a concentration of 10 mM. These findings highlight the promising antimicrobial and antibiofilm properties of these compounds, indicating the potential for their further investigation as potential therapeutic agents against the tested pathogens.
Veganism and Oral Health—An Overview through the Perspective
Authors: Pandya Visha Shailesh , Fiorillo Luca , Kalpe Sneha , Mehta Vini , Meto Aida , Certo Agostino Di , Russo Diana , Gorassini Francesca , Mancini Maura , Mancini Alessandra , D'Amico Cesare
Published: October 2023

When meat and dairy products are no longer consumed, the practice of veganism, which forgoes the use of animal products, substantially impacts diet. The prevention and treatment of diseases like rheumatoid arthritis, diabetes, neurodegeneration, hypertension, and vascular diseases are usually aided by vegan diets. Vegan diets are associated with improved cardiovascular health and better nutrition quality than omnivorous diets. Vegans and vegetarians have a lower risk of periodontal disease but may be more prone to tooth erosion and dental caries due to deficiencies in vitamin B12 and lower saliva pH. A vegetarian or vegan diet may increase the risk of developing tooth erosion, but an omnivorous diet may increase the risk of periodontal disease and dental caries. Further clinical research must be performed to produce more statistically significant results and to support future studies that contrast omnivore, vegetarian, and vegan diets and their effects on dental health status.
Tooth as a Bone Graft Material: A Narrative Review
Authors: Obulareddy Vishnu Teja , Porwal Amit , Noor Toufiq , Catalano Francesco , Minervini Giuseppe , D'Amico Cesare , Mancini Maura , Gorassini Francesca , Fiorillo Luca , Cervino Gabriele
Published: October 2023

To treat osseous defects, a range of bone grafts and their replacements have been accessible, but appropriate reconstruction by any bony defect persists as a therapeutic hurdle. Based on peer-reviewed literature, the current narrative review analyzes significant outcomes in patients treated with bone grafts and bone graft substitutes for surgical therapy of osseous defects. Despite autograft, xenograft, and alloplastic bone graft substitutes being employed in several periodontic procedures, they all have their restrictions. Autogenous tooth bone graft is functional in clinics due to different available forms, which can be availed for other clinical challenges. Moreover, genetic uniformity fosters efficient bone regeneration by allowing osteoinduction and osteoconduction and reducing foreign body reactions.