bluuebunny/crossref_metadata_2025 huggingface dataset:
Momentum space separation of quantum path interferences between photons and surface plasmon polaritons in nonlinear photoemission microscopy
Authors: Dreher Pascal , Janoschka David , Giessen Harald , Schützhold Ralf , Davis Timothy J. , Horn-von Hoegen Michael , Meyer zu Heringdorf Frank-J.
Published: March 2024

Quantum path interferences occur whenever multiple equivalent and coherent transitions result in a common final state. Such interferences strongly modify the probability of a particle to be found in that final state, a key concept of quantum coherent control. When multiple nonlinear and energy-degenerate transitions occur in a system, the multitude of possible quantum path interferences is hard to disentangle experimentally. Here, we analyze quantum path interferences during the nonlinear emission of electrons from hybrid plasmonic and photonic fields using time-resolved photoemission electron microscopy. We experimentally distinguish quantum path interferences by exploiting the momentum difference between photons and plasmons and through balancing the relative contributions of their respective fields. Our work provides a fundamental understanding of the nonlinear photon–plasmon–electron interaction. Distinguishing emission processes in momentum space, as introduced here, could allow nano-optical quantum-correlations to be studied without destroying the quantum path interferences.
Prognostic value of a glycolysis and cholesterol synthesis related gene signature in osteosarcoma: implications for immune microenvironment and personalized treatment strategies
Authors: Feng Jinzhu , Zhang Jie , Chen Yong
Published: March 2024

Objectives

Osteosarcoma stands as a highly aggressive primary bone malignancy with a notable penchant for metastasis and a grim prognosis. The exploration of metabolic gene signatures, particularly those involved in glycolysis and cholesterol synthesis, has recently garnered attention for their potential to predict cancer progression and therapeutic outcomes. This study probes the prognostic value of a glycolysis and cholesterol synthesis-related gene signature (GCSRG) in osteosarcoma, along with its influence on the tumor immune microenvironment.

Methods

A comprehensive bioinformatics approach was applied to osteosarcoma samples from the TCGA database, incorporating unsupervised clustering to delineate patient subsets, differential gene expression analysis to identify key metabolic pathways, and survival analysis to ascertain prognostic validity.

Results

The investigation yielded a distinct GCSRG with significant prognostic capabilities. Notably, a high GCSRG score correlated with worse patient outcomes but revealed a marked enrichment in immune cell infiltration within the tumor milieu, suggesting a complex relationship between metabolism and immune surveillance in osteosarcoma.

Conclusion

The GCSRG emerges as a promising biomarker for osteosarcoma prognosis, offering new vistas for assessing patient suitability for immunotherapeutic interventions. The potential of the GCSRG to act as a guide for personalized treatment strategies is highlighted, underscoring the need for strategic therapeutic modulation based on metabolic and immune interactions to improve patient prognosis in osteosarcoma.
Improving thermal performance of turbine blade with combination of circular and oblong fins in a wedge channel: a numerical investigation
Authors: Venkatesh Goveraiahgari , Meenakshi Reddy Reddygari , Rao Pabbisetty Mallikarjuna
Published: March 2024

Because of its narrow and aerodynamic design, cooling the trailing edge of a turbine blade offers an essential problem. For the trailing edge internal cooling of gas turbine blades, wedge-shaped channels are used. Pin-fin arrays play a critical role in enhancing heat transmission at the trailing edge of turbine blades. The flow and heat transfer properties of a number of wedge channels with staggered pin-fins of varied shapes are used to develop a design with a more effective heat transfer effect and reduced flow resistance. The present study compares the combination of circular pin fins and oblong pin fins in a wedge duct with a Reynolds number range of 12,000–85,000 and a constant heat flux (surface) of 3280 W/m2 applied to the bottom wall, top wall, and surfaces of the fins. The results indicate that the pressure loss is less in circular fins at the centre and oblong fins side by side, and it is 23.67 % less than circular and oblong fins in opposite positions. The Heat transfer coefficient for circular and oblong fins in opposite positions is 16.72 % higher than circular fins at centre and oblong fin side by side. The thermal performance factor is almost the same for both cases.
G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases
Authors: Shen Shengnan , Liao Qiwen , Gu Liwei , Zhu Yongping , Liu Yanqing , Zhang Xinwei , Zhang Junzhe , Shi Qiaoli , Sun Yuxiang , Wang Jigang , Lin Ligen
Published: March 2024

G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. GPCR-biased agonism has raised the potential of novel drug development to preferentially activate therapeutic signaling pathways over pathways that lead to unwanted side effects. The obesity epidemic and its metabolic complications continue to be a major global public health threat but effective treatments are limited. The accelerated development of structural techniques, like X-ray crystallography and cryo-electron microscopy, has paved the way to understanding how biased agonism measured at GPCRs results in specific downstream physiologic responses. Herein some well-validated GPCR targets are briefly summarized and several new and promising receptors for obesity treatment are outlined. This review highlights the significance of deciphering the role of GPCRs in obesity pathology and biased signaling for drug development. We anticipate the review will facilitate the development of novel GPCR-targeted anti-obesity drugs that lead to heightened therapeutic efficacy with decreased side effect profiles.
Sarcopenia-related Traits, Body Mass Index and Ovarian Cancer Risk: Investigation of Causal Relationships Through Multivariable Mendelian Randomization Analyses
Authors: Wu Manli , Chen Jiahao , Kuang Xiaohong , Chen Ying , Wang Ying , Huang Licong , Su Manting , Chen Yaqiong , Qu Enze , Zhang Xinling
Published: March 2024

Objective: This study was aimed at exploring the causal relationships of four sarcopenia-related traits (appendicular lean mass, usual walking pace, right hand grip strength, and levels of moderate to vigorous physical activity) with body mass index (BMI) and ovarian cancer risk, by using univariable and multivariable Mendelian randomization (MR) methods.

Materials and Methods: Univariable and multivariable MR was performed to estimate causal relationships among sarcopenia-related traits, BMI, and ovarian cancer risk, in aggregated genome-wide association study (GWAS) data from the UK Biobank. Genetic variants associated with each variable (P < 5 × 10−8) were identified as instrumental variables. Three methods—inverse variance weighted (IVW) analysis, weighted median analysis, and MR-Egger regression—were used.

Results: Univariable MR analyses revealed positive causal effects of high appendicular lean mass (P = 0.02) and high BMI (P = 0.001) on ovarian cancer occurrence. In contrast, a genetically predicted faster usual walking pace was associated with lower risk of ovarian cancer (P = 0.03). No evidence was found supporting roles of right hand grip strength and levels of moderate to vigorous physical activity in ovarian cancer development (P = 0.56 and P = 0.22, respectively). In multivariable MR analyses, the association between a genetically predicted faster usual walking pace and lower ovarian cancer risk remained significant (P = 0.047).

Conclusions: Our study highlights a role of slower usual walking pace in the development of ovarian cancer. Further studies are required to validate our findings and understand the underlying mechanisms.
Reproducibility of a New Method to Assess Endothelial Function According to Peripheral Arterial Volume
Authors: Liu Yuanqiao , Zhao Yanan , Li Zihan , Yang Ping , Si Daoyuan
Published: March 2024

Background: The assessment of endothelial function is crucial for understanding cardiovascular disease progression. Reliable, convenient non-invasive methods are necessary for evaluating endothelial function. Peripheral arterial volume (PAV), measured at the fingertip, is a novel approach for which limited reproducibility data are available. Hence, this study was aimed at evaluating PAV measurement reproducibility in a clinical setting.

Method: A total of 152 consecutive patients (average age 55.8 ± 12.3 years, 83 men) with chest pain were included in the study. PAV tests were conducted on the same day. The amplitude ratio before and after application of pressure, along with the reference ratio, were recorded to calculate the PAV. Medical baseline data for these patients were gathered from the hospital’s records.

Result: On test days, the PAV results from repeated measurements were 1.15 ± 0.33 and 1.15 ± 0.31 (P = 0.99), indicating no significant difference between measurements in all participants. The mean difference was 0.00 ± 0.32, thus indicating no systematic errors, and the intraclass correlation coefficient was 0.66. Furthermore, age, sex, and BMI did not influence PAV reproducibility.

Conclusion: PAV measurement is feasible and exhibited excellent reproducibility among all enrolled patients. As a novel fingertip measurement, PAV has promise as a convenient and accurate method for assessing endothelial function in adults.
Transcatheter Aortic Valve Replacement in Patients ≥80 and <80 Years of Age with Aortic Valve Stenosis at Moderate Surgical Risk: Findings from an Observational Study in the Vietnamese Population
Authors: Nguyen Khoa Quoc , Van Nguyen Duong , La Thuy Thi , Van Nguyen Tan , Than The Ngoc Ha , Nguyen Thach N. , Dinh Hoang VK , Nguyen Cong Duc , Thanh Nhan Vo
Published: March 2024

Objectives: The increasing number of elderly patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) has prompted concerns regarding their clinical outcomes compared with the younger population. This study evaluated the outcomes of TAVR on the basis of age group (<80 or ≥80 years) among Vietnamese patients with severe aortic valve stenosis at intermediate surgical risk.

Methods: From March 2017 to December 2022, 21 patients ≥80 years of age and 69 patients <80 years of age underwent TAVI at a single center. Clinical characteristics, procedures, and outcomes at 30 days and 1 year were compared with the Valve Academic Research Consortium (VARC-2) criteria.

Results: Patients ≥80 years of age had a higher prevalence of comorbidities but no significant differences in other clinical characteristics and procedures. No statistically significant differences were observed in procedural mortality (4.8% vs. 0.0%, P = 0.233), 30-day mortality (5.0% vs. 1.5%, P = 0.405), and 1-year mortality (11.8% vs. 3.7%, P = 0.241) between age groups. Major endpoints at specified time points also showed no significant differences.

Conclusions: TAVR in patients with aortic stenosis at intermediate surgical risk has similar clinical outcomes at 30 days and 1 year, according to VARC-2 criteria, with no statistically significant age-associated differences (≥80 vs. <80 years). However, further studies with larger patient populations are needed to better understand the effects of age on TAVI outcomes in patients with similar characteristics.
Exploring the intersections of AI (Artificial Intelligence) in psychology and astrology: a conceptual inquiry for human well-being
Authors: Banerjee Padmakali , Sindhu Braham Deep , Sindhu Swati , Puri Amita , Puri Astha , Bamel Purnima , Kumar Aman , Singh Taniya , Ravinder Sharma Acharya , Sharma Vikas , Dev Nayar Kapil
Published: March 2024

Psychology and astrology are two disciplines that, at first glance, may seem unrelated. However, upon closer examination, there are intriguing intersections between the two that merit exploration. This conceptual note delves into the relationship between psychology and astrology, examining how insights from both fields can contribute to human well-being. By synthesizing psychological principles with astrological frameworks, individuals may gain deeper self-awareness, cultivate resilience, and navigate life's challenges with greater understanding and purpose
УКРАЇНА ЯК ЗАРУЧНИЦЯ ДЕРЖАВИ
Authors: ХОМИН Петро
Published: March 2024

Розглянуто причини затяжного відставання економіки України від тих країн, які не мають порівнянного з нею природного потенціалу. Зокрема, відзначено, що незалежно від періодів, умовно поділених на тоталітарний, волюнтаристський, стагнацію й «перебудову» з імітацією переходу до ринкової економіки включно, Україна ніяк не може позбутися статусу заручниці держави,  тобто апарату політичної влади в суспільстві, який ніколи не допускав не те що кардинальних змін у економічній системі, але й будь-яких косметичних на кшталт косигінської реформи чи «перебудови».

Унаслідок приходу до влади демагогів, замість проведення виваженого реформування системи економічних відносин тривалий час відбувалося руйнування промисловості й аграрного сектору, катастрофічно знижувались обсяги випуску технічних засобів виробництва, виник критичний дисбаланс не тільки між рослинництвом і тваринництвом, але й усередині цих галузей. Отже, Україна, яка була флагманом серед країн Східної Європи, втратила свої лідерські позиції як у промисловості, так і в сільському господарстві. У свою чергу, Польща, економіку якої реформували освічені інтелектуали, з типової аграрної країни перетворилася на розвинуту промислово-аграрну державу.

За сучасної ситуації відбувається відплив за кордон з України найбільш продуктивних за віком працівників, у тому числі й кваліфікованих спеціалістів, а значна частка створеної їхньою працею продукції з доданою вартістю нерідко імпортується Україною, чим майже подвоює прибуток зарубіжних роботодавців за рахунок мігрантів і українських споживачів. І такий стан справ набув непереборних ознак, незважаючи на те, що з державного бюджету щороку виділялися мільярдні дотації на підтримку як видобувної промисловості (зокрема, вугільної), так і сільського господарства.
Peran Dan Kontribusi Badan Usaha Milik Desa (BUMDES) Terhadap Perokonomian Masyarakat
Authors: Erial Sidiq Muhammad , Aziz Rohmanur , Aziz Ali
Published: March 2024

Salah satu persoalan serius yang dihadapi bangsa ini adalah tingkat kesenjangan ekonomi. Badan Usaha Milik Desa (BUMDes) merupakan salah satu lembaga yang dijadikan sebagai wadah pemersatu dan pemberdayaan masyarakat. BUMDes berusaha mengintegrasikan program dengan masalah-masalah kemasyarakatan yang erat kaitannya dengan bidang-bidang ekonomi. Salahsatu pemberdayaan masyarakat melalui rintisan BUMDes yaitu di Desa Rancaekek Wetan Kecamatan Rancaekek Kabupaten Bandung bernama BUMDes Kampung Responsif Dinamis (KRD). Kelompok ini merupakan proses pemberdayaan yang diharapkan dapat menggalang tanggung jawab bersama dalam memelihara lingkungan teruatama dalam penanggulangan sampah namun berdampak secara ekonomi. Salah satu tindakan yang dilakukan dengan menyediakan wadah bagi masyarakat itu sendiri sebagai akses untuk menuju masyarakat yang berdaya. Dengan dibentuknya rintisan BUMDes melalui program bank sampah bisa menjadi salah satu wadah yang dapat mengembangkan pendapatan masyarakat dengan cara pengelolaan sampah dengan baik. rintisan BUMDes merupakan kegiatan yang strategis guna meningkatkan partisipasi masyarakat dalam pengelolaan sampah menjadi potensi ekonomi dan kebersihan lingkungan Rancaekek Wetan.Kata kunci: BUMDes, Pemberdayaan, Ekonomi, dan KRD
Sosialisasi Pembiayaan Simas Haji IB Dengan Akad Ijarah di Bank Sinarmas Syariah Kc Arcamanik Bandung
Authors: Latifah Novi , Suryana Yanyan , Indrayana Yusman Nova
Published: March 2024

Pembiayaan Simas Haji iB dengan Akad Ijarah di Bank Sinarmas Syariah Kantor Cabang Arcamanik Bandung. Pada saat ini beragam produk ditawarkan oleh Sinarmas Syariah salah satunya produk Pembiayaan Simas Haji iB. Produk Pembiayaan Simas Haji iB pada Sinarmas Syariah ini hadir sebagai solusi yang baik bagi mereka yang kesulitan/kekurangan dana untuk melaksanakan Ibadah Haji. Penelitian ini membahas tentang Pembiayaan Simas Haji iB dengan Akad Ijarah di Bank Sinarmas Syariah Kantor Cabang Arcamanik Bandung. Adapun tujuan penelitian ini untuk mengetahui syarat dan ketentuan Pembiayaan Haji, prosedur Pembiayaan Haji, analisa perhitungan Ujrah, serta penerapan akad Ijarah di Bank Sinarmas Syariah Kantor Cabang Arcamanik Bandung. Hasil penelitian mengenai Pembiayaan Simas Haji iB dengan Akad Ijarah di Bank Sinarmas Syariah dapat disimpulkan secara ringkas yaitu terdapat 7 syarat untuk karyawan, 7 syarat untuk non karyawan dan 5 ketentuan yang harus dipenuhi. Terdapat 10 prosedur yang melibatkan 6 pihak yaitu Nasabah, Customer Service, Branch Manager, Micro Business, Analisis Micro dan Teller. Sistem perhitungan Ujrah menggunakan perhitungan akad Ijarah.Kata kunci: Pembiayaan Haji, Ijarah.
eningkatan Kompetensi Bidang Akuntansi Bagi Guru SMK yang Tergabung Dalam MGMP Akuntansi Kota Cimahi
Authors: Apriliawati Yeti , Irawan Arry , Sutrisno Putra Sugih , . Setiawan
Published: March 2024

The quality of teachers in vocational education has an important role in producing graduates who are competitive in the industry. In fact, there are still many Vocational High School (SMK) teachers who do not yet have expertise competency certificates. This is one of the reasons for the high unemployment rate in Indonesia, which is dominated by SMK graduates at 10.42 percent in August 2019. According to the head of the Accounting Subject Teacher Board (MGMP) in the Cimahi, 21 accounting teachers members of the MGMP do not have a competency certificate. Based on these problems, we held training activities to add insight for vocational teachers regarding competency certification for accounting teachers in vocational schools in accordance with the competency certification scheme, and improve practical teaching skills through practicum modules that are in accordance with industrial conditions. The implementation of the PKM program begins with compiling training materials, conducting online pre-tests, evaluating pre-test results, training 5 competency units online, conducting face-to-face competency test simulations, providing simulation scoring results, and providing feedback regarding scoring results. From the results of this activity, the teachers who were treated showed high enthusiasm and were able to receive the training material well with indicators of post test results that were better than the pre test.Keywords: Competency Certification; Vocational high School; Accounting Competence
Dampak Penggunaan Platform Digital Terhadap Perkembangan UMKM Indonesia
Authors: Shakira Eva , Rahmawulan Husna Karima , Asih Vemy Suci
Published: March 2024

Transformasi digital dalam bisnis UMKM semakin berkembang pesat, mengubah perilaku manusia dan mempercepat proses digitalisasi. Maka dukungan Platform Digital terhadap UMKM harus ditingkatkan agar UMKM memiliki nilai tambah sehingga UMKM bisa naik kelas. Penelitian Perkembangan Platform Digital terhadap UMKM di Indonesia ini bertujuan agar mengetahui sejauh mana UMKM menggunakan Platform Digital untuk bertransaksi. Metode Penelitian ini menggunakan dua jenis Metode yaitu Metode Literatur dan Metode Kualitatif, dengan menggunakan studi Pustaka pada metode Literatur serta Teknik Observasi, penyebaran angket dan wawancara pada Metode Kualitatif untuk mengumpulkan data kepada 10 pengusaha UMKM di Kabupaten Bandung, Indoensia. Hasil Penelitian ini menunjukan bahwa perkembangan platfrom digital terhadap UMKM hampir semua UMKM sudah menggunakan platform digital untuk bertransaksi. Dari Penelitian ini dapat diketahui bahwa melalui Platform Digital sebagai wadah untuk bertransaksi, UMKM mengalami perkembangan usaha. Kata kunci: Platform Digital, UMKM
PANDANGAN EKONOMI ISLAM PADA DESENTRALISASI FISKAL DAN PERTUMBUHAN EKONOMI DAERAH DI JAWA BARAT
Authors: Zaky Muhammad
Published: March 2024

Indonesia kaya dan beragam secara geografis, bahasa, etnis dan budaya. Keunikan ini berdampak signifikan terhadap pembangunan ekonomi pada setiap daerah. Penelitian yang bertujuan untuk menganalisis pandangan ekonomi Islam terhadap desentralisasi fiskal dan pertumbuhan ekonomi di Provinsi Jawa Barat, mencerminkan minat untuk mengeksplorasi hubungan antara prinsip ekonomi Islam, sistem desentralisasi fiskal dan dampaknya terhadap pertumbuhan ekonomi. Untuk menganalisis kajian kebijakan desentralisasi fiskal dan pertumbuhan ekonomi dalam pandangan Islam, penelitian ini menggunakan pendekatan kualitatif dengan metode literature review. Secara keseluruhan, hasil positif dari penelitian ini adalah pertumbuhan ekonomi di 27 kabupaten/kota administratif Provinsi Jawa Barat stabil setiap tahunnya. Hal ini menunjukkan bahwa proses pembangunan perekonomian daerah berada dalam keadaan yang cukup baik. Hasil penelitian ini sesuai dengan tujuan ekonomi Islam, yaitu untuk mencapai keseimbangan, dengan tujuan akhir kebahagiaan dunia dan kebahagiaan akhirat (falah). Pertumbuhan ekonomi Kabupaten Majalengka merupakan yang tertinggi di antara 27 kabupaten/kota administratif di Provinsi Jawa Barat, sehingga menunjukkan pertumbuhan ekonomi yang baik di wilayah tersebut.
Nowe instytucje prawa prewencyjnego oparte na wiedzy
Authors: Olszewski Jan
Published: March 2024

Celem artykułu jest analiza prawna dwu instytucji nieznanych szerzej w Polsce. To "amicus curiae" i "compliance". Ich wspólną cechą jest możliwość oddziaływania prewencyjnego, a także to, iż uzewnętrzniają się poprzez wytworzenie, a następnie prezentację nowej wiedzy w stosownej dla siebie formie. W ramach opisu ustalono szereg pojęć odnoszących się do tych instytucji. Następnie naświetlono zalety prewencji prawnej i tworzenia nowej wiedzy. Ostatecznie autor krok po kroku omawia, jak praktycznie uruchomić obie instytucje i czerpać z nich korzyści organizacyjne, wizerunkowe, a czasem też ekonomiczne. Walorem opracowania są także liczne wnioski. Przede wszystkim ukierunkowane będą na wskazanie prawodawcom, jak w Polsce ułatwiać komercjalizację wiedzy i w większym zakresie pozyskiwać wiedzę ze środowisk naukowych.
Assumptions of the Schengen Borders Code and the Schengen Information System and their role in preventing illegal border crossings
Authors: Semków Dorota
Published: March 2024

On December 21, 2007, Poland joined the Schengen Zone. The decision to abolish controls at the internal borders of the EU and the accession of nine new member states to the Schengen Zone was one of the most significant steps toward the full realization of European integration. The expansion of the Schengen Zone contributed significantly to the construction of a united Europe based on mutual trust, collectively striving to maintain a high level of security. The Schengen Agreement’s provisions eliminated controls for individuals crossing borders between member states of the agreement while strengthening police, judicial, security, and asylum policy cooperation. The main focus of this article is on the provisions of the Regulation (EU) 2016/399 of the European Parliament and of the Council of March 9, 2016, concerning the Union Code on the rules governing the movement of persons across borders, also known as the Schengen Border Code. The primary objective is to highlight this Code as a tool for preventing the illegal crossing of Schengen Zone borders, which is closely related to combating crimes against document credibility. The publication also addresses issues related to the functioning of the Schengen Information System.
Kompetencje Państwowej Komisji do spraw przeciwdziałania wykorzystaniu seksualnemu małoletnich poniżej lat 15 wobec art. 240 k.k.
Authors: Służalec Michał
Published: March 2024

Ustawa powołująca do życia Państwową Komisję do spraw przeciwdziałania wykorzystaniu seksualnemu małoletnich poniżej lat 15 wdrożyła szereg rozwiązań odnośnie do zabezpieczenia przed przestępstwami z obszaru wolności seksualnej i obyczajności małoletnich. Szczególne znaczenie Komisji przejawia się w kontekście art. 240 k.k., tj. karalności niezawiadomienia o popełnieniu określonych przestępstw. W opracowaniu omówiono znaczenie Komisji w procesie ścigania sprawców przestępstw z art. 240 k.k., jej kompetencje, oddziaływanie na prowadzenie postępowania karnego w tym przedmiocie, jak również stanowiska odnośnie do wykładni przepisów po 13 lipca 2019 roku.
Szczególna rola samorządu terytorialnego w zakresie ochrony zabytków i opieki nad zabytkami
Authors: Smarż Joanna
Published: March 2024

Jedną z ważniejszych funkcji administracji publicznej jest świadczenie usług polegających na zaspokajaniu podstawowych potrzeb ludności. Świadcząca rola administracji realizowana jest szczególnie na poziomie samorządu terytorialnego, m.in. w zakresie ochrony zabytków. Zachowanie w dobrym stanie obiektów zabytkowych jest istotne dla państwa i samorządu, gdyż stanowią one dobro ludzkości. Szczególną rolę w tym zakresie odgrywa gmina, która została zobowiązana m.in. do prowadzenia gminnej ewidencji zabytków, utworzenia parku kulturowego oraz spełnia kluczową rolę w ustalaniu przeznaczenia i zasad zagospodarowania terenu.
Wybrane elementy prawne wpływające na system ochrony zdrowia
Authors: Bróż Oskar , Podolak Agnieszka
Published: March 2024

Artykuł 168 TFUE określa działania Unii Europejskiej w dziedzinie ochrony zdrowia, pozwalając państwom członkowskim na swobodę w decydowaniu o priorytetach systemu ochrony zdrowia. Ze względu na ograniczone zasoby podejmowanie decyzji o kształcie zdrowia publicznego realizuje się na podstawie polityk i strategii, które obejmują zadania z zakresu zdrowia publicznego. W artykule wskazano wybrane elementy prawne, które zdaniem autorów w kontekście realizacji zadań zdrowia publicznego powinny w przyszłości pełnić ważną rolę w systemie ochrony zdrowia.
Wybrane aspekty funkcjonowania zbiorów danych daktyloskopijnych. Utworzenie bazy eliminacyjnej dla zbioru automatycznie przetwarzającego dane daktyloskopijne
Authors: Kruczek Magdalena
Published: March 2024

Blisko 130 lat po pierwszym opisanym przypadku identyfikacji osoby na podstawie śladu linii papilarnych, w epoce systemów bazodanowych i międzynarodowej wymiany danych zachodzącej w czasie rzeczywistym, 20 lat od wprowadzenia w Polsce AFIS – zbioru automatycznie przetwarzającego dane daktyloskopijne, kiedy wydawać by się mogło, że o daktyloskopii powiedziano i napisano już wszystko, powstaje zbiór eliminacyjny, w którym gromadzone są odciski linii papilarnych oraz wymazy ze śluzówki policzków od funkcjonariuszy i pracowników Policji. Nowe regulacje otwierają dyskusję, w której argumentacja przebiega wielokierunkowo, bo od zarzutów o zbyt daleko posuniętą ingerencję w sferę osobistą funkcjonariuszy, mowa jest przecież o gromadzeniu i przetwarzaniu profili DNA i danych daktyloskopijnych, po koszty utworzenia zbioru eliminacyjnego. Czym zatem są zbiory daktyloskopijne oraz AFIS, jak funkcjonują i co wpływa na ich skuteczność w realizacji celów wykrywczych i identyfikacyjnych w sprawach karnych? Ten obszar daktyloskopii służącej organom ścigania do zwalczania i zapobiegania przestępczości stał się przedmiotem analizy niniejszego artykułu.
Hacia la caracterización de los valores democráticos y ciudadanos de las niñas y niños escolares: una mirada desde la filosofía para niños
Authors: Fajardo Pascagaza Ernesto
Published: March 2024

Este artículo busca caracterizar los valores democráticos y ciudadanos de las niñas y niños escolares desde una mirada filosófica. El artículo se contextualiza a partir de sus voces y expresiones sobre lo que conocen y vivencian como realidad de patria tanto dentro del aula, como en las relaciones humanas socializadoras con su entorno escolar y familiar. Como fundamentación teórica se aborda el marco normativo y el desarrollo del conocimiento sobre lo ciudadano, la construcción de la convivencia y la paz, la promoción de la pluralidad y la identidad, la formación transversal en todas las áreas del conocimiento, así como la construcción de ambientes democráticos pacíficos. Finalmente, se presenta un ejercicio reflexivo sobre la educación para la democracia desde la perspectiva de la filosofía para niños, centrada en el desarrollo de procesos de pensamiento más efectivos, críticos y solidarios desde el pensamiento autónomo, interpretativo, argumentativo, propositivo y comunicativo, hacia el rescate de procesos de participación ciudadana y democrática escolares. Así mismo, el conocimiento de los argumentos tanto de Estado como institucionales de tales procesos, a los que tienen derecho y que tienen que convertirse en deberes en virtud de su nacionalidad y de su condición escolar.
Abordaje discursivo de una caricatura política
Authors: Morales Escorcia Efraín , Samper Suárez Josefa
Published: March 2024

Este artículo ilustra el análisis del discurso de una caricatura política y consta de tres partes centrales. Primero, la elucidación de las características generales de los fenómenos discursivos señaladas por Dominique Maingueneau (2005); luego, la caracterización general de la puesta en escena del lenguaje propuesta por Patrick Charaudeau (1986, 1992) y, finalmente, el abordaje sucinto de la enunciación desde la perspectiva de Bajtín/Voloshinov (1998). Para tal cometido, se toma como pretexto una caricatura política de Vladdo, publicada en 2011 en la revista Semana, y se emplea el método empírico- deductivo para la explicación de la misma. Conforme a su propósito, el artículo muestra la operatividad de estas tres perspectivas discursivas, sus convergencias y las diversas posibilidades que ofrecen para el estudio del lenguaje.
Art and Craft of Music Therapy for Stroke Rehabilitation in a Remote North Indian Community
Authors: Rajagopal Sahitya , Street Alex , Philip Stephen W.
Published: March 2024

This case study describes how a music therapist (Stephen) and a music therapy intern (Sahitya) worked conjointly with a client and her granddaughter in a remote part of North India. The description provides a unique insight into conditions, culture, and lifestyle in this location, and how these two clinicians were able to merge broader arts-based and holistic approaches, on a journey towards client-centered and functional neurologic music therapy exercises to help the client regain more independence. The background to initial work undertaken by the music therapist, which lasted for one year and eleven months, is followed by a summary of five weekly conjoint sessions with the intern, including the evolution of exercises, rationale, and client responses, illustrated with embedded video excerpts. The communication, relationship, and trust-building with the client and her granddaughter, together with the intern joining the dynamic, paved the way for assimilating music therapy theoretical models that were new to them, and adapting neurologic music therapy approaches using an electronic keyboard that incorporated preferred facilitating music. This resulted in greater client engagement with higher levels of motivation and adherence and increased hand use in daily activities.
Selecting the Best Music for the Moment in a Music and Imagery Session
Authors: Jerling Petra , Angulo Sánchez-Prieto Carmen , Solana Rubio Isabel
Published: March 2024

Music and Imagery (MI) is a receptive music therapy method within the Continuum Model of Guided Imagery and Music developed by Lisa Summer. In receptive music therapy, clients listen to music for therapeutic purposes. The unique part of the MI method is that the client’s own music can be used. Three qualified music therapists from two countries trained together in the MI method and were grouped together for supervision. Moving away from the traditional therapist-client dyad model, we worked as a trio, with the third person in our trio actively witnessing the session and sharing her perspectives and reflections during the post-session discussion. This article focuses on discussing our experiences in selecting music for our individual processes, since this selection is the new concept in the MI method, called the transition. To report our experiences, we chose to use trioethnography. Each author told her own story, whilst the others took part actively in a small intervision group as critics, friends, and colleagues. In this way, we acknowledged each other’s processes as clients, therapists, and witnesses. Our experience of using intervision to explore the new concept of transition (choosing music) and reporting on that process using trioethnography was very positive. It became clear that intervision can be meaningful for all music therapists in clinical settings, and that trioethnography should be further explored as a research approach.
"He Has Rescued Me from Danger"
Authors: Bishop Sarah
Published: March 2024

The Ethio-South Sudanese border is characterized by instability and conflict. Most populations in this area have experienced violence and displacement and face ongoing insecurity and political inequality. During my fieldwork in the region, several composers gave accounts of how composing and singing Christian songs provided them with comfort and hope in times of hardship, particularly following episodes of violence. Using ethnographic research and interviews as primary methodologies, this article explores how these individuals use religious music-making as a means of coping and resilience in the wake of trauma. The primary goal of this article is to provide a platform for their stories. The secondary goal is to explore resonances between their accounts and scholarly observations about potential roles of music-making in trauma resilience across disciplines. I focus particularly on themes of embodied music-making, community connection, and spirituality. All point to the same phenomenon: that music can play a role in human resilience and meaning-making. Finally, I make suggestions on how to enhance mental health care in culturally-relevant ways in a religious society such as in Ethiopia, as well as draw out cross-cultural implications for mental health care in the western system.
Myth of Political Neutrality
Authors: Honig Tim , Hadley Susan
Published: March 2024

This editorial discusses the roles and meaning of the “political” in music therapy journals and publication processes and calls into question the value and expectation of political neutrality. It also outlines the articles included in the March 2024 issue.
Caracterização geofísica da Cobertura Detrito-Laterítica e seu aquífero no Chapadão de São Gabriel do Oeste, MS
Authors: Neumann Odirlei , Gabas Sandra Garcia , Lastoria Giancarlo
Published: March 2024

A caracterização geofísica da cobertura detrito-laterítica existente no Chapadão de São Gabriel do Oeste-MS, de fundamental importância econômica para a agricultura da região, foi objeto de estudo desta pesquisa, destacando-se as cangas lateríticas associadas, amplamente utilizadas no revestimento primário dos mais de 3000 km de rodovias municipais. Buscou-se avaliar a eficácia do método geofísico GPR na identificação das cangas lateríticas em subsuperfície e na detecção dos contatos litológicos do TQdl com as camadas subjacentes. Foi dado um enfoque na verificação da continuidade da Formação Serra Geral na área de estudos, com obtenção do mapa de isoespessuras. Complementarmente, foi efetuada uma caracterização preliminar do aquífero relacionado à cobertura ainda não individualizada. Para alcançar tais objetivos, usou-se da obtenção de dados geofísicos com o GPR, Eletrorresistividade e dados geológicos e hidrogeológicos. Como resultados finais, são apresentadas:  a viabilidade de emprego do GPR na identificação das cangas; a espessura da Cobertura detrito-laterítica e seus contatos; a definição da distribuição e da espessura dos basaltos da Fm. Serra Geral e a definição do mapa potenciométrico do aquífero representado pela cobertura. Adicionalmente, obteve-se um perfil geológico buscando o melhor entendimento do arcabouço geológico-estrutural, o qual sintetiza a interpretação das relações estratigráficas na área.
TNF ELISA Protocol v1
Authors: not provided caitlynhenry
Published: March 2024

The purpose of this experiment is to investigate the effects of forskolin-mediated cAMP activation on TNF-ɑ secretion by LPS-treated Schwann cells. The immortalized rat RT4-D6P2T cell line (ATCC #CRL-2768) was cultured and received one of the following treatments: 0.1, 1, or 10 μg/mL of LPS, in N2 media (control) or N2 media supplemented with 2 μM of forskolin, for 3 hours. Cell media samples were collected, and the Rat TNF-alpha ELISA kit (RayBiotech, Cat #ELR-TNFa-1, Norcross, GA) was performed to quantify changes in TNF-ɑ secretion in response to the different treatment combinations.
Axial compressive behavior of recycled aggregate concrete steel composite columns
Authors:   Department of Civil Engineering, Hindustan Institute of Technology and Science, Cruze Daniel , Sah Chandan ,   Department of Civil Engineering, Hindustan Institute of Technology and Science, Manikanta Nijampatnam ,   Department of Civil Engineering, Hindustan Institute of Technology and Science, Mandal Dhirendra Kumar ,   Department of Civil Engineering, Hindustan Institute of Technology and Science, Jha Abhinash Kumar ,   Department of Civil Engineering, Hindustan Institute of Technology and Science, Solomon A. Arun ,   Department of Civil Engineering, GMR Institute of Technology
Published: March 2024

In this Study the axial load-carrying capacity and behavior of a “Axial Compressive behavior of Recycled Aggregate Concrete Steel Composite Columns” (RACSCC) is investigated experimentally and simulated numerically. The study emphasizes the utilization of materials contributing to the circular economy in construction, specifically integrating steel and recycled aggregate into concrete. The environmentally sustainable concrete columns are formed by filling square steel tube sections with recycled aggregate concrete (RAC). The study includes six SRACC specimens and one bare conventional steel column. The specimens are subjected to axial compressive loading using the displacement control method. The investigation explores the impact of different coarse aggregate sizes of 12 mm, 16 mm, 22.4 mm, 25 mm, and 30 mm, obtained through sieving of demolished buildings materials. The study aims to address the impact of varying aggregate sizes on parameters such as maximum load-carrying capacity, strain, stress, lateral displacement, and failure patterns. The experimental results are validated and compared with the maximum load-carrying capacity, Strain, Stress, Lateral displacement, and failure patterns using numerical simulations conducted with the Ansys Workbench tool. The SRACC column comprises a hollow tube with 20 mm to 22.4 mm and 22.4 mm to 25 mm recycled aggregate and has a maximum load carrying capacity of 610.28 kN at 10 mm displacement. The local buckling failure occurred near the area load applied. The numerical simulations result for the composite columns agreed well with the experimental results. The results show the recycled aggregate concrete (RAC) have a massive potential for construction support in circular economy. To create composite columns using the RAC as an alternative building material that will help to create an environmentally Sustainable construction
Natural deep eutectic solvents: promising agents for extracting substances from plant materials
Authors: Andrusenko Elena V. , Glushakov Ruslan I. , Redkin Gregory A.
Published: March 2024

There is a growing trend to replace synthetic products or additives with natural alternatives. Historical experience and developments in human health science demonstrate the adverse effects of xenobiotics on human health and metabolism. The shift toward natural products is essential for enhancing vitality, social activity, and overall quality of life, while preventing adverse events and diseases. Industries such as pharmaceutical, cosmetic, and food are increasingly turning to natural and biologically active chemicals isolated from plants or microorganisms. However, the primary challenge lies in developing effective and eco-friendly methods for their isolation. Deep eutectic solvents are a mixture of two or more components with unique properties like low volatility, low melting points, ease of preparation, cost-effective starting materials, and minimal toxicity to humans. They have gained popularity as environmentally friendly agents for extracting biologically active substances from medicinal plants and as safe alternatives for various industries, including food and pharmaceuticals. Traditional organic solvent extraction methods have several drawbacks, including long extraction times, safety concerns, environmental damage, high cost, and the need for large solvent volumes. This review summarizes research progress on the benefits of using deep eutectic solvents for extracting bioactive compounds, including phenolic acid, flavonoids, isoflavones, catechins, polysaccharides, curcuminoids, proanthocyanidin, phycocyanin, gingerols, ginsenosides, anthocyanins, rutin, and chlorogenic acids. Additionally, it examines the biological activity of these extracts, including antioxidant, antibacterial, and antitumor properties.
Dynamics of gonadotropin and thienopyrimidine derivative TP03 effects on ovulation and ovarian steroidogenesis in Follimag-stimulated immature female rats
Authors: Derkach Kira V. , Bakhtyukov Andrey A. , Sorokoumov Viktor N. , Didenko Egor A. , Romanova Irina V. , Morina Irina Yu. , Lebedev Ivan A. , Bayunova Lyubov V. , Shpakov Alexander O.
Published: March 2024

BACKGROUND: Gonadotropin preparations, particularly human chorionic gonadotropin (hCG), are commonly used to induce ovulation and treat reproductive disorders in women, albeit with associated side effects. Low-molecular-weight allosteric agonists of the luteinizing hormone receptor (LHR), such as thieno[2,3-d]pyrimidine derivatives, offer a potential alternative.
AIM: This study aims to compare the effects of thieno[2,3-d]pyrimidine TP03 and hCG on ovarian weight, corpus luteum formation, and plasma levels of estradiol, progesterone, and luteinizing hormone in immature female rats pre-treated with Follimag®. It also examines their impact on ovarian gene expression related to LHR and steroidogenesis.
MATERIALS AND METHODS: TP03 and hCG were administered 48 h after the Follimag® injection at a dose of 20 mg/kg (i.p.) and 15 IU/rat (s.c.), respectively. Parameters were assessed at 1, 2, 4, 8, 16, and 24 h after TP03 and hCG administration. Plasma hormone levels were measured via ELISA, and ovarian gene expression was analyzed using real-time PCR.
RESULTS: TP03 increased ovarian weight, progesterone levels in the blood, and expression of steroidogenic genes encoding the cholesterol-transporting protein StAR and the cytochromes CYP11A1 and CYP17A1. TP03 also stimulated corpus luteum formation (16–24 h after treatment). The temporal dynamics of its stimulating effects were similar to those of hCG, although their magnitude was slightly inferior to those of gonadotropin. TP03-induced decrease in blood estradiol levels and aromatase gene expression in the ovaries was also more moderate. Unlike hCG, which suppressed LHR gene expression 8 h after treatment, TP03 maintained a high LHR gene expression, preserving ovarian sensitivity to endogenous luteinizing hormone.
CONCLUSIONS: TP03 exhibits potential as an ovulation inducer with milder stimulating effects on ovarian steroidogenesis than hCG, which reduces the risks of developing ovarian hyperstimulation syndrome and resistance to gonadotropins.
Pharmacological correction of experimentally induced osteoporosis complicated by type 2 diabetes mellitus
Authors: Bairamov Alekber  A. , Mamina Nailya  Sh. , Karonova Tatiana  L. , Simanenkova Anna  V. , Kozhyurin Mikhail  V. , Kosyakova Galina  P. , Shabanov Petr D.
Published: March 2024

BACKGROUND: Osteoporosis remains one of the most important medical problems worldwide with significant economic consequences. The development of new drugs based on unique biologically active compounds can contribute significantly to osteoporosis management.
AIM: To evaluate the osteogenesis processes by evaluating bone-remodeling markers in the blood serum during the treatment of experimental osteoporosis complicated by type 2 diabetes mellitus.
MATERIALS AND METHODS: The study was performed on an experimental model of osteoporosis, followed by the induction of type 2 diabetes mellitus, using biochemical methods to analyze markers of osteoporosis in the blood serum.
RESULTS: The results of the analysis of bone remodeling markers revealed that the antiosteoporotic activity of a composite preparation based on succinic acid salts is dependent on glucose metabolism disorders such as diabetes mellitus. The high efficacy of the new drug in monotherapy and combination with vitamin D3 in the activation of osteogenesis in experimental osteoporosis was balanced by impaired metabolic processes in type 2 diabetes mellitus.
CONCLUSIONS: The results indicate the dependence of the pharmacological effectiveness of the antiosteoporosis agent on metabolic disorders, such as type 2 diabetes mellitus, in female rats with experimental osteoporosis.
Role of key endocannabinoids and their receptors in breast cancer
Authors: Akimov Mikhail G. , Dudina Polina V. , Vyunova Tatiana V. , Kalueff Allan V. , Gretskaya Natalia M. , Bezuglov Vladimir V.
Published: March 2024

Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.
Specific Mutations Identified in Patients Vaccinated and Infected with COVID-19 in Senegal
Authors: Padane Abdou , Wade Djibril , Diedhiou Cyrille , Sarr Marièma , Ndiaye Seyni , Souaré Abdoulaye , Diop Mame , Gueye Khadim , Aza-Gnandji Marilyne , Diagne Ndèye , Leye Nafissatou , Diouf Ndèye , Ndiaye Mame , Dabo Ndèye , Sow Ndèye , Wade Djibril , Ndoye Souadou , Diallo Abdoul , Ndiaye Anna , Dia Yacine , Lo Gora , Diallo Abdoulaye , Diop Ousmane , Mboup Aminata , Ahouidi Ambroise , Diaw Papa , Cissé Badara , Mbow Moustapha , Camara Makhtar , Kane Ndéye , Mboup Souleymane
Published: March 2024

Background: Vaccination against SARS-CoV-2 is currently the best preventive measure to control the COVID-19 pandemic. However, in some cases, it appeared that despite the vaccination, some people were reinfected. Aim: The objective of this study is to monitor preliminary data of COVID-19 reinfection cases in vaccinated individuals in Senegal. Methods: In this study, we used the Oxford Nanopore MinION portable sequencer as detailed in the ARTIC network to test SARS-CoV-2 positive samples from reinfected patients. A total of 71 subjects were monitored with 37 vaccinated patients and 34 non-vaccinated and samples were sequenced in genomic platform at IRESSEF. Results: We noted the presence of three major lineages B.1.617.2, AY4 and AY34 in vaccinated people. In addition, the mutation W152R and two other mutations never described (T1136S and V1137L) were found in tested genomic sequences. Conclusion: These results will contribute to monitor future epidemics and to control the effectiveness of the vaccination against COVID-19 especially the Variant of Concern and allow us to improve surveillance for COVID-19 pandemic.