bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of High- and Mid-Fidelity Computational Fluid Dynamics for Complex Ship Airwake Analysis with New Experimental Data
Authors:   Georgia Institute of Technology, Oates Brenden , Kurban Erk , Smith Marilyn , Rauleder Juergen
Published: July 2023

Safe flight with maneuvers of rotorcraft systems in the near vicinity of Naval ships poses a number of challenges due to the complex, unsteady wake shedding from the ship surface. To prepare pilots to operate in these conditions, it is desired to ensure accurate ship airwake simulation capabilities that provide an understanding of the flow field and are sufficiently cost-effective so that they can be applied in flight simulators to enhance pilot training and safety. While the simple frigate shape (SFS2) geometry has been extensively studied, assessments of the flow environment with respect to practical usage in flight simulations have experienced fewer analyses. A high-fidelity, conventional unsteady unstructured Reynolds-Averaged Navier-Stokes CFD solver (FUN3D) and novel time-resolved particle image velocimetry measurements are evaluated with Lattice-Boltzmann Method (LBM) simulations to understand LBM's potential for real-time flight simulations. LBM predictions are overall relatively comparable to FUN3D and PIV, albeit with some loss in magnitude and detail, but at computational time savings of several orders of magnitude to unstructured CFD. Ship orientations with yaw experiencing winds have more differences between LBM and FUN3D than non-yawed orientations.
Full-Aircraft CH-53K® Hover Simulations with Helios
Authors:   Sikorsky A Lockheed Martin Company, Klimchenko Vera , Min Byung-Young , Zhao Jinggen , Wake Brian , Kim Jeewoong
Published: July 2023

The CH-53K® King Stallion™ is the most advanced heavy lift helicopter developed by Sikorsky, a Lockheed Martin Company, to address the requirements of the United States Marine Corps. The aircraft was designed to support missions with a maximum design gross weight of 88000 lbs and can carry external loads up to 36000 lb. Full-aircraft HELIOS calculations were performed for a CH-53K King Stallion including main rotor, tail-rotor, fuselage and detailed hub. Calculations were performed for various configurations, with main-rotor removed, tail-rotor removed, and isolated main and tail rotors to evaluate the multiple interactional effects. Comparisons of the total power show excellent agreement with the flight-test measurements.
Infrared Thermography Measurements over an eVTOL Full-Scale Wing Section Equipped with Propellers Mounted on a Boom
Authors:   Politecnico di Milano, Riccobene Luca ,   DLR - German Aerospace Center, Braukmann Johannes ,   Archer Aviation, Kerho Mike , Zanotti Alex , Grassi Donato , Droandi Giovanni
Published: July 2023

The present paper describes the results of an experimental wind tunnel test campaign aimed at investigating and characterizing the complicated aerodynamic flow patterns around a wing section equipped with propellers mounted on a boom. The investigated configuration is meant to be representative of a full-scale eVTOL aircraft in cruise flight condition. The Infrared Thermography technique enabled a quantitative evaluation of the amount of laminar flow for the baseline airfoil section and also for the wing airfoil under the influence of the propeller at different thrust conditions.
Coaxial Hub Drag Correlation With Water-Tunnel Model Using Two Flow Solvers
Authors:   Sikorsky a Lockheed Martin Company, Min Byung-Young , Sharma Kalki , Berezin Charles , Lorber Peter , Wake Brian
Published: July 2023

Current paper summarizes a correlation study of two flow solvers (CREATE-AV™ Helios and STAR-CCM+), routinely used at Sikorsky, with the spinning coaxial hub drag and flow field measurements conducted by Penn State University at the 12' diameter water tunnel. The Helios modeling approach was aiming for a high fidelity accurate simulation, whereas the STAR-CCM+ modeling approach was aiming for a fast turn-around time with reasonable solution accuracy with a relatively coarse mesh and simplification. The two solvers generally agreed well with the test data within reasonable accuracy and captured the drag trend between two shaft fairing configurations. Impact of turbulence model selection (Spalart-Allmaras Detached Eddy Simulation and Spalart-Allmaras Reynolds-Averaged-Navier-Stokes model) has been demonstrated. The RANS model generally delayed separation and resulted in lower drag. The STAR-CCM+ runs simulated both air and water at matching Reynolds number and showed good agreement between the drag results for the two mediums. Also, the importance of accurate representation of geometric details including gaps, shafts, and holes is highlighted.
CH-53K Maneuvering Envelope Expansion Challenges
Authors:   Sikorsky Aircraft Corporation, Rucci John ,   NAVAIR, Slingerland Laura , Pupalaikis Rob , Knaust Glen , Maloney Sean , Faynberg Alex , Ream Don , Spoldi Steven , Lamb Rich , Cahill Kenneth
Published: July 2023

The CH-53K® heavy-lift helicopter, contracted under the Heavy Lift Replacement Program, is nearing the end of development, and was recently approved for Full Rate Production (FRP). The CH-53K features a full authority Fly-By-Wire (FBW) flight control system with Model Following Control Law architecture, chosen to address several overarching requirements including Level 1 Handling Qualities in accordance with ADS-33E-PRF. Early system identification of the air vehicle and tuning of the Flight Control System (FCS) allowed for an incremental expansion in airspeed, altitude, and maneuvering envelope. During the maneuver envelope expansion forward cyclic control margin (B1s) became a limiting factor. The reduced margin was noted during aft CG configurations when expanding load factor. Control margin limits and Do Not Exceed (DNE) criteria were established for safe expansion early in the test planning process. These criteria were based on best practices, specifications, desktop, and simulation models as well as engineering judgment prior to first flight. Some influence of the criteria likely derived from the defunct MIL-H-8501A Military Specification 'General Requirements for Helicopter Flying and Ground Handling Qualities,' with a notable absence of quantitative criteria in ADS-33E-PRF. As the full authority FBW control system was demanded to work within a smaller forward portion of the control authority envelope for mission-representative aft CG configurations, the DNE criteria challenged the long-standing general guidelines regarding control margins. Furthermore, control margin DNE's were experienced primarily during maneuver recovery-not through pilot input but via a closed loop response to the Model Following architecture and had the potential to restrict unnecessarily the boundaries of the Operational and Service Flight Envelope (OFE/SFE). Challenged with the task of envelope expansion, the Integrated Test Team (ITT) comprising contractor and government flight test engineers and pilots, worked to refine flight test technique and continuation criteria to validate the maneuvering requirements of the Air Vehicle Specification (AVS). Ultimately, the ITT developed a criterion for expansion of a modern FBW system to demonstrate the full capability in all corners of the envelope and deliver a superbly flying aircraft to the end customer, the United States Marine Corps (USMC).
Impact of Rotor-Rotor and Rotor-Body Aerodynamic Interactions on Quadrotor Vehicle Performance
Authors:   The Ohio State University, Herz Sage ,   Georgia Institute of Technology, Atte Abraham , Seth Dhuree , McCrink Matthew , Rauleder Juergen
Published: July 2023

Rotor-rotor and rotor-body interactions can have a first-order impact on multirotor vehicle performance. Identification of these performance impacts has previously been limited to numerical analysis and controlled environment testing, and they are largely unknown for full-scale multirotor flight vehicles. To capture these interactional effects, the work presented in this paper used a series of wind tunnel and flight test experiments of a quadrotor vehicle at multiple speeds and sideslip angles to estimate these rotor-rotor and rotor-body interactions. Performance data was measured for individual rotors and for the overall vehicle at flight speeds ranging from 5 to 15 m/s. Results indicated that aft rotor performance decreased by 4.8% in the cross configuration with the fuselage. In the plus configuration, the fuselage resulted in a 3.8% decrease in the aft rotor thrust coefficient. Rotor performance between cross and plus configurations was measured in a series of flight tests, where the plus configuration had a higher overall thrust coefficient than the cross configuration. Inwardly rotating rotors resulted in a 5.0% increase in thrust coefficient compared to outwardly rotating rotors. Measured trends in rotor performance between the cross and plus configurations were highly nonlinear with respect to sideslip angle and vehicle velocity.
Associations of Alcohol Consumption and Smoking Behaviors with Depressed Mood According to Gender in Korean Young Adults
Authors: Hwang Jung Won , Eun Youngmi , Song Chan-Hee
Published: July 2023

Background: Recent studies have reported that chronic mental health problems often emerge in young adulthood. This study elucidated the independent effects of smoking and drinking on depressed mood in young adults by sex.Methods: We used Data from the Korea National Health and Nutrition Examination Surveys conducted in 2014, 2016, and 2018. A total of 3,391 participants aged 19–35 years, without serious chronic diseases, were recruited for this study. Depression was evaluated using the Patient Health Questionnaire (PHQ-9).Results: Smoking behavior, current smoking, and number of days smoked were significantly associated with higher PHQ-9 scores in both men and women (all P<0.05). However, past and ever smoking were positively associated with PHQ-9 scores only in women (all P<0.001). Regarding alcohol consumption, the age at which drinking first began was negatively associated with PHQ-9 scores in both men and women (all P<0.001), but the amount of alcohol consumed at 1 time was positively associated with PHQ-9 scores only in women (P=0.013). Men who drank 2–4 times a month and women who had not drunk during the past year had the lowest PHQ-9 scores.Conclusion: Smoking and alcohol consumption were independently associated with depressed mood in young Korean adults, which was more pronounced in women, and exhibited sex-specific characteristics.
COVID-19 in Hematological Malignancies
Authors: Ocheni Sunday , Nwagha Theresa Ukamaka , Amu Nneka , Obodo Onochie Ikenna , Okereke Kelechi , Chikezie Kelechi , Ejezie C. S. , Ilechukwu Gladys Udoka , Obiatuegwu Chiemelie
Published: July 2023

Earlier reports suggest that cancer patients were twice more likely to contract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this report, we describe two patients with hematological malignancies seen at the peak of the first wave of the coronavirus disease 2019 pandemic. A 61-year-old man was referred to our urology unit he was diagnosed with nodular hyperplasia and multiple myeloma and commenced on bortezomib, thalidomide, and dexamethasone combination chemotherapy. He developed a cough and fever, with SPO2 86%, He was positive for SARS-CoV-2 and died a few days later. A 42-year-old man with Hodgkin lymphoma on treatment with Adriamycin, bleomycin, vincristine, and dacarbazine with positive SARS-CoV-2 exposure was diagnosed with pleural effusion at A/E. Three days postadmission, his condition worsened with low SPO2 despite intranasal oxygen. He died after testing positive for SARS-CoV-2. Patients with hematological malignancies tend to have a greater risk of SARS-COV-2 infection and severe disease due to immunosuppression from cancer and its treatment.
Exposure to tobacco advertisements, promotions, and sponsorships among in-school adolescents in Lagos, Nigeria
Authors: Odukoya Oluwakemi , Ladapo Olamide , Okafor Ifeoma , Osibogun Olatokunbo , Okuyemi Kolawole
Published: July 2023

Background:

The Nigerian government implemented the National Tobacco Control Act (NTCA) in 2015, which prohibits tobacco advertising, promotion, and sponsorship (TAPS) exposure to children under 18 years of age. This study was conducted to assess the prevalence of attitudes and exposure to TAPS among in-school adolescents in Lagos State, Nigeria, 5 years after the implementation of the Act and to identify the factors associated with TAPS exposure among the adolescents.

Materials and Methods:

This cross-sectional study was conducted among 968 in-school adolescents selected through multistage random sampling. The data were collected using self-administered questionnaires adapted from the Global Youth Tobacco Survey.

Results:

Overall, 77% had been exposed to at least one form of TAPS in the past 30 days. The most frequently reported channel of exposure was through product placements, with 62% reporting exposure in films, TV, and videos. Up to 15.2% and 12.6% were exposed to TAPS through promotional activities and sponsorships, respectively. The majority (82.3%) had pro-tobacco attitudes, while about a third (33.1%) had pro-TAPS attitudes. Factors associated with TAPS exposure were having pro-TAPS attitudes (odds ratio [OR]: 3.5, 95% confidence interval [CI]: 2.3–5.3), being female (OR: 2, 95% CI: 1.4–2.7), and residing in a rural area (OR: 1.6, 95% CI: 1.2–2.3).

Conclusion:

Five years after implementing the NTCA, more than two-thirds of the adolescents reported exposure to TAPS, mainly through films, TV, and videos. This suggests that the NTCA is poorly enforced. Efforts to ensure the effective implementation of comprehensive TAPS bans are warranted. Gender-sensitive strategies that target adolescents' attitudes and school-level factors should be emphasized.
Outcome of COVID-19 Infection and the Impact of COVID-19 Vaccination in Chronic Kidney Disease Patients
Authors: Kolla Madhuri , Rout Nikunj Kishore , Gupta Saurabh , Mohapatra Sangram Keshari , Alone Vivek D. , Singh Pratima
Published: July 2023

Introduction:

Chronic kidney disease (CKD) patients have increased vulnerability to infections including Covid-19. There is limited availability of antiviral in CKD patients. All guidelines have prioritized vaccinations for CKD patients. The variability in immunogenic response is multifactorial in CKD group. We have tried to analyze the outcome of Covid-19 infection and the impact of COVID-19 vaccination [COVAXIN / COVISHIELD] in our cohort.

Materials Methods and Statistical Analysis:

In a retrospective observational study, 73 cases of Covid-19 positive CKD patients were selected, who were managed as per MOFHW guidelines. The data of first laboratory values and radiological findings were evaluated. Their treatment outcome and stay during hospitalization were studied. All data were later analyzed using STATA 16.1 software.

Results:

In this study, 73 cases of CKD with Covid-19 were included. There were 38 patients who were vaccinated with at least one dose of the Covid-19 vaccine, while there were 35 patients who were unvaccinated. Out of 38 patients, 20 were vaccinated with 2 doses of Covid-19 while 18 received only one dose. The unvaccinated group was having more hypoxia and raised inflammatory markers, and had more lung involvement [i.e. higher CT severity value] [p value for CTSS-0.0765]. There was a higher mortality rate observed in the unvaccinated group [i.e-65.71%] than the vaccinated group [39.47%] [p-value 0.0249]. Dialysis was needed in 57.50% of the study population either due to failure of conservative management for renal failure or due to maintenance dialysis. The mean duration of hospitalization was 11.47 days with a mortality rate of 52% which is much higher than the reported average data in CKD patients.

Conclusion:

Vaccination seems to be very helpful in combating the adverse effect of Covid-19 in CKD patients. It also reduces mortality significantly in Covid-19 infected CKD patients.
Accessory Heads of Biceps Brachii Muscle its Embryogenesis and Clinical Implications
Authors: Chakravarthi Kosuri Kalyan , Sarvepalli Ankamma , Siddegowda Siddaraju Kaadukothanahalli , Nelluri Venumadhav
Published: July 2023

Background:

Biceps brachii is an elongated two-headed fusiform muscle of the anterior compartment of the arm which crosses the shoulder as well as the elbow joint. It assists in flexion of the shoulder joint and elbow joint and powerful supinator of the forearm. It also assists in the abduction of the shoulder joint. Accessory heads of biceps brachii muscle not only give additional strength to the joints, at the same time, they may also simulate soft-tissue tumors that can result in neurovascular compression.

Aims and Objectives:

Accordingly, the aim of this study was designed to evaluate the prevalence of accessory heads of biceps brachii muscle in human cadavers.

Materials and Methods:

This study was conducted on 107 formalin embalmed human cadavers (male 62 and 45 female), and dissections were performed in accordance with the institutional ethical standards and the Indian Anatomy Act.

Results:

Out of 107 cadavers, three-headed biceps brachii was noted in 18 cadavers (16.82%) associated with the unusual course of musculocutaneous nerve. Rare and unusual unilateral five-headed biceps brachii was noted in one male cadaver (0.93%). All accessory heads noted in this study were supplied by the separate branches of musculocutaneous nerve except the humeral head of five-headed biceps, which was supplied by the radial nerve.

Conclusion:

Awareness of these anatomical variations, knowledge is necessary for radiologists, anesthetists, physiotherapists, and orthopedic surgeons to avoid complications during various radiodiagnostic procedures or surgeries of flexor deformities of the upper arm and forearm.
Huge Abdominopelvic Mass Arising from Cervical Fibroid around an Infected Cervical Diverticulum: A Very Rare Case and a Review of Literature
Authors: De Arpita , Tripathi Reva , Jain Abhinav , Rana Safia
Published: July 2023

ABSTRACT

Primary uterine diverticula are a very rare congenital anomaly of the uterus with only 21 reported cases. Even rarer is the occurrence of primary cervical diverticula with only six cases reported so far. This is a unique case of a huge abdominopelvic mass arising from cervical fibroid around an infected cervical diverticulum. A 44 year-old, P4L4 came to the OPD with a eighteen weeks size abdomino-pelvic mass. She had a failed surgery 6 months back, attempted to remove the mass. Magnetic resonance imaging revealed a cervical diverticulum which possibly had a pus collection. Relaparotomy was done. It revealed a huge cervical fibroid with dense adhesions all around the mass. A pan hysterectomy was done. In the postoperative period, she developed high-grade fever owing to the development of a pelvic collection, which had to be drained by dilating the vault sutures. Histopathology report confirmed a cervical fibroid with an infected diverticulum within. Primary uterine or cervical diverticula are a very rare anamoly which possibly arise because of a weakness in the area where the two mullerian ducts fuse. Women with this rare condition may suffer from infertility, fever and pain abdomen, acute abdomen owing to torsion or hemoperitoneum, pregnancy complications, and menorrhagia. Diverticulectomy and cervical/uterine reconstruction can be done on nulliparous women while hysterectomy can be offered to perimenopausal women. To conclude, unless known by the gynecologists, radiologists, and the pathologists, this diagnosis can be easily missed out, leading to multiple preventable complications.
Skin Metastases in Ovarian Malignancy: A Case Report with Literature Review
Authors: Pipal Vibha Rani , Singh Pratibha , Pipal Dharmendra Kumar , Elhence Poonam
Published: July 2023

ABSTRACT

Ovarian cancer is the most lethal gynecologic malignancy, mostly diagnosed in the advanced stage with multiple sites of metastases. Routes of spread are direct through exfoliation, lymphatic channels, and less commonly hematogenous spread. Skin metastasis in ovarian malignancy is a rare occurence, its incidence range from 1.9% to 5.1% and the most common sites are the abdominal wall and chest wall. The incidence of metastasis to breast and/or axillary lymph nodes is very rare, ranging from 0.03% to 0.6%. We report the case of a 60-year-old female with stage IV B undifferentiated ovarian carcinoma with multiple cutaneous metastases involving the skin over the left breast, scalp, and mediastinal lymph nodes, which are rare sites of metastases. The incidence of cutaneous metastasis in ovarian cancer is 1.9%–5.1% and the overall survival after diagnosis ranges from 2 to 65 months.
Unilateral Ectopic Breast Tissue in the Vulva - A Diagnostic Dilemma
Authors: Sanchita Dashora , Ruchi Joshi
Published: July 2023

ABSTRACT

Ectopic breast tissue is a rare condition caused by remnants of the mammary ridges that fail to involute during embryologic development. Clinical presentation of vulval breast tissue is highly variable and diagnosis is ultimately made by tissue biopsy and histopathological examination. Since this ectopic tissue serves no function, surgical excision is recommended. Vulval ectopic breast tissue is an extremely rare case, especially in midlife. Because of its rarity in occurrence and unusual site, here we report a case of unilateral ectopic breast tissue on the vulva in an adult midlife female.
Отрицательное уравнение Пелля и статические конфигурации точечных вихрей на плоскости
Authors: Vishnevskaya Anna , Demina Maria Vladimirovna
Published: July 2023

Работа посвящена изучению модели точечных вихрей, предложенной немецким ученым Германом Гельмгольцем. Найдены необходимые и достаточные условия существования бесконечного числа неэквивалентных статических конфигураций для системы, состоящей из двух точечных вихрей интенсивности $\Gamma_1$ и произвольного числа точечных вихрей интенсивности $\Gamma_2$. Проведена классификация таких конфигураций. Впервые обнаружена связь между отрицательным диофантовым уравнением Пелля и статическими конфигурациями точечных вихрей на плоскости.
Библиография: 20 названий.
О некоторых факторгруппах гиперболических групп
Authors: Kulikova Olga Viktorovna
Published: July 2023

В данной работе описываются некоторые обобщения результатов, изложенных в книге "Геометрия определяющих соотношений в группах" А. Ю. Ольшанского, на случай нециклических гиперболических групп без кручения. В частности, доказывается, что для всякой нециклической гиперболической группы без кручения существует неабелева факторгруппа без кручения, у которой все собственные подгруппы являются циклическими, а пересечение любых двух из них отлично от единицы.
Библиография: 9 названий.
A QUALIDADE DA GOVERNANÇA CORPORATIVA E A DIVULGAÇÃO ENVIRONMENTAL, SOCIAL AND GOVERNANCE INFLUENCIAM A RELEVÂNCIA DAS INFORMAÇÕES CONTÁBEIS?
Authors: Meneghel Marcia Ferraz , Kieling Débora Londero , Degenhart Larissa
Published: July 2023

A presente pesquisa busca analisar a influência da qualidade da governança corporativa e da divulgação Environmental, Social and Governance (ESG) na relevância das informações contábeis de empresas brasileiras. A metodologia caracteriza-se como descritiva, quantitativa e documental, com a análise de um período de cinco anos (2016 a 2020) das empresas brasileiras pertencentes ao índice Brasil 100 (IBrX-100) da Brasil, Bolsa e Balcão (B3). Para o tratamento dos dados foi realizada uma regressão de dados em painel para as três equações propostas. Os resultados indicaram que a variação de lucros (ΔEARN) e o índice de governança corporativa (IQGC) se relacionaram positivamente e significativamente com o retorno das ações (RET). Por outro lado, o efeito da divulgação ESG (geral) no retorno das ações não foi confirmado, pois não houve relação estatística significativa. No entanto, na análise individual dos fatores ESG (ambiental, social e governança) foi confirmada uma relação positiva e significativa somente da divulgação social (SOC) no RET, constituindo-se como potencial oportunidade de investimento para as organizações. Esses resultados sugerem que o conjunto de práticas que denotam a qualidade da governança corporativa e a divulgação social são relevantes para se alcançar maiores níveis de retorno de ações. Esta pesquisa contribui no sentido de impulsionar incentivos para que as organizações contemplem em sua estrutura de governança mecanismos eficazes e invistam em ações e estratégias ESG, visto os efeitos positivos encontrados no value relevance.
Dynamics of the content of immunoglobulins in the blood serum and vaginal secretion of cows with genital mycoplasmosis during treatment with tulathromycin
Authors: Vasiliev Roman M. , Vasilieva Svetlana V.
Published: July 2023

An important task of industrial animal husbandry is to maintain the reproductive health of female animals. Indolent diseases of the reproductive system remain a big problem. Little information is available on the immunopathogenesis of genital mycoplasmosis. Antibiotic treatment with drugs from tetracycline, macrolide or fluoroquinolone groups is the main approach to treatment of mycoplasmosis. The aim of the present work was to study the dynamics of immunoglobulin contents in blood serum and vaginal secretions of cows with genital mycoplasmosis during therapy with tulathromycin, a semi-synthetic macrolide antibiotic drug.
We studied two groups of cows at their interlactation period (n = 8), aged 3-4 years. Control group consisted of clinically healthy cows. The cows from experimental group had confirmed genital mycoplasmosis. They were treated with Traxovet 100 antibiotic (tulathromycin) at a dose of 2.5 mg per 1 kg of animal body weight, by subcutaneous route, 40 days before the expected delivery. Blood serum and vaginal secretions were collected in both groups of animals. The contents of IgG, IgM, IgA immunoglobulins, and sIgA in the vaginal secretion were determined by radial immunodiffusion (Mancini technique).
On the 14th day of the experiment, a significant increase in the IgG contents and decreased levels of IgM and IgA were observed in the blood of the cows from experimental group. However, these indexes still remained lower than in healthy cows. In vaginal secretions, a significant decrease in the IgM and sIgA amounts was detected. The immunoglobulin levels in vaginal secretions after antibiotic therapy did not differ from the healthy cows.
The use of tulathromycin for treatment of genital mycoplasmosis in pregnant cows shows high therapeutic efficacy, but does not lead to a complete normalization of their immunoglobulin status.
Function of human skin T cells in wound healing in the in vitro experimental setting
Authors: Kostolomova Elena G. , Strelin Svyatoslav A. , Sukhovei Yuri G. , Unger Irina G. , Akuneeva Tatiana V. , Markov Alexander A. , Polyanskikh Elizaveta D.
Published: July 2023

Currently, the treatment of persistent non-healing wounds is among the most difficult clinical issues. We studied 20 samples of normal human skin, 10 specimens from patients with acute trauma, and 9 samples from the patients with chronic wounds that did not heal within 2 months. Using multicolor flow cytometry, we found that the resident T lymphocytes (CD3++ and CD3++) are able to locally produce biologically active substances, normalize human skin homeostasis, thus promoting the wound healing. The data obtained indicate that the blood contains mainly +T lymphocytes (p 0.001), while the +T cells detected in wounds represent a population similar to skin cells. We found no difference in the ratio of resident T cells in chronic and acute wounds, and healthy epithelium. Accordingly, non-healing of wounds and chronic clinical course may be caused by dysfunction of T cells. CD69 regulates T cell secretion of growth factors, IFN, IL-17 and IL-22. The relative number of CD69-expressing T cells from the patients with acute wounds was significantly increased, if compared with cells from normal epidermis and chronic wounds (10.5%2.3, 7.6%1.24, and 3.0%1.05, respectively. p 0.001). The number of cells with the CD3++CD69+ phenotype did not differ significantly between all three groups under comparison. Dysregulation of T cell-mediated healing in chronic wounds is caused by reduced production of IGF-1 by resident CD3++T lymphocytes (1.7%0.9 (p 0.001), and CD3++ (0.44%0.02, p 0.001) compared to CD3++T cells derived from acute wounds (13.6%5.6) and CD3++ (8.9%3.1). The + and + T cells isolated from non-healing chronic wounds did not respond to mitogenic stimuli, unlike the cells obtained from acute wounds and healthy skin. In vitro analysis of cytokine secretion by the CD69-deficient dermal T cells showed a lower spontaneous secretion of IL-22 (4.56%2.3 and 23.9%1.05 and 10.6%1.24, respectively; p 0.001) and IL-2 (0.9%0.08 and 22.6%2.5 and 3.9%1.0, and respectively; p 0.01). When analyzing the number of resident skin T cells secreting IL-17, we obtained the following differences for healthy skin (1.4%0.08), acute wounds (11.3%3.2) and chronic wounds (31.7%11.8), thus showing a significant intergroup difference (p 0.001). T lymphocytes in chronic wounds exhibit some functional disorders and are not able to produce biologically active substances that promote physiological tissue regeneration. The results suggest a role of resident T cells in human skin in wound healing processes and provide new insights into the pathogenesis of chronic wounds.
May be dysfunction of cellular immunity considered a sign of post-COVID syndrome?
Authors: Asfandiyarova Nailya S. , Rubtsova Mariya A.
Published: July 2023

Our aim was to study association between proliferative activity of peripheral blood lymphocytes after COVID, and developing post-COVID syndrome, and to determine whether the cell immunity dysfunction may be regarded as its marker. The retrospective cohort study involved 242 patients (56 males, 186 females, 18 to 85 years old) who contracted new coronavirus infection. Of them, post-COVID syndrome was diagnosed in 180 cases (duration over 3 months). The patients were classified by severity of clinical course of COVID (i.e., presence of acute respiratory disease and pneumonias), and PHA-induced blast transformation of lymphocytes. Along with PHA-induced response, we studied cyclooxygenase (COG)-producing cells by morphological method. Control group consisted of 200 healthy people without any features of coronavirus infection. All patients were questioned and examined by multidisciplinary medical team, dependent on their complaints. We also registered incidence of comorbidities associated with cellular immune deficiency. The patients with post-COVID syndrome exhibited a decrease of PHA-induced lymphocyte proliferation as compared with control group (significant at p 0.01 in cases of acute respiratory infection, and p 0.05 in patients with pneumonia). Activity of COG-producing cells was similar in all groups, independently on presence of post-COVID syndrome. Classification of patients by presence of cellular immune dysfunction (PHA-induced blast transformation 50%) allowed to detect higher activity of COG-producing cells. This enzyme is known to participate in development of inflammation promoting immune deficiency, thus, probably, manifesting in clinical activation of herpesvirus infection following COVID-19. Activity of COG-synthesizing cells was found to be higher in post-COVID syndrome which evolves after middle-severe and severe forms of new coronavirus infection complicated by pneumonias. Chronic inflammation in post-COVID syndrome associated with high activity of COG-producing cells may promote dysfunction of cell immunity, thus being a cause of evolving syndrome, like as its biomarker. Absence of the immune cell dysfunction markers among other post-COVID features leads to decreased registration of post-COVID patients and misinterpretation of the results obtained.
Exploring What Teacher's Decision-Making in Designing Mathematical Assignments?: Case Studies in Beginner
Authors: Taufiq Taufiq , Budiarto Mega Teguh , Siswono Tatag Yuli Eko
Published: July 2023

Objective: This research uses the M-Four theory to investigate how teachers design mathematical tasks based on contextual problems. Method: The research involves a case study approach, utilizing in-depth observations, interviews, and Mathematical Task Design Sheets (MTDS) for data collection. This study involved one Beginner Teacher (BT) (age 35) participating who was selected based on teacher experiences. Through observation results, a BT who consistently assigns contextual math problems is selected for further analysis. Results:  The study's findings reveal that BT tends to produce contextual assignments that primarily focus on the context presented in the textbook, with minimal additions or adjustments based on real-life situations experienced by students. This research contributes to the existing literature on problem-based learning and task design by examining the perspectives of BT. It provides insights for teacher professional development programs and curriculum design. Novelty: The novelty of this research lies in its exploration of how BT designs mathematical tasks based on contextual problems using the M-Four theory.
La science ensemble : pratique de l’interdisciplinarité au sein d’un projet d’observatoire de l’habitat du futur
Authors: Alévêque Guillaume , Laurent Anne , Libourel Rouge Thérèse , Nourrit-Lucas Déborah
Published: July 2023

Cet article propose l'observation ethnographique et l’analyse interdisciplinaire d’un projet scientifique constitué d’une diversité de disciplines autour de la thématique de l’habitat du futur. Matérialiser par un appartement truffé de capteurs habité à l’année (universitaire) par deux étudiants volontaires et sélectionnés, la collaboration entre les chercheurs y prend une forme originale qui permet de réévaluer ce que représente l’Interdisciplinarité au sein de la recherche scientifique contemporaine. Fait social complexe, elle devient elle-même un objet sur lequel les acteurs projettent des stratégies et des attentes à la conjonction des multiples dimensions qu’elle sous-tend aussi comme organisation de la collaboration, méthodologie, perspective de résultats et incitation institutionnelle ambivalente.
Análise do material lítico resgatado na fronteira oeste do RS
Authors: Lemes Lucio , Loureiro André Garcia
Published: July 2023

O presente artigo apresenta uma síntese dos trabalhos realizados no Salvamento Arqueológico intitulado “Programa de Gestão do Patrimônio Arqueológico na Área de Instalação do Grupo Sant´Ana 1”. A região do Salvamento foi à campanha oeste do Rio Grande do Sul, mais especificamente as cidades de Alegrete, Quaraí e Santana do Livramento. Historicamente esta área foi ocupada pela reconhecida indústria Catalanense. Desta forma, apresentaremos um resumo de 3 sítios dos arqueológicos dos 55 sítios resgatados e as interpretações de suas paisagens e suas tecnologias.
Spectrum of Congenital Heart Diseases in Children at a Tertiary Care Centre: A Cross-Sectional Study
Authors: Satish Rane Ms. Sakshi , Shinde Dr. Abhijeet Asaram , Mhaske Prof. Dr. Sunil Natha
Published: July 2023

Introduction: A gross anatomical anomaly of the heart or intrathoracic great vessels that is actually or potentially functionally significant is referred to as congenital heart disease (CHD). One of the main reasons for newborn mortality is CHDs. A significant hospital-based study from India estimates that 3.9 out of every 1000 live babies are affected by congenital heart disease. Thus, we conducted this research with the aim to study the prevalence, age-wise distribution, and clinical spectrum of congenital heart disease (CHD) in a tertiary care medical college hospital in Maharashtra. Methodology: This was a retrospective, descriptive, cross-sectional study carried out from March 2020 to March 2022 at a tertiary care hospital and medical college. The study included records of all discharged live births (CHD patients) as well as all in and outpatients between the ages of 0-18 years. For the diagnosis of CHD, a definition proposed by Mitchell et al. was applied. Results: CHD was detected in 9 out of 645 live births in the hospital during the study period. 168 children were diagnosed to be having some type of CHD. Ventricular septal defect was the most common heart lesion 43 (25.6%). Maximum number of cases were seen in 0-3 years age group (86.3%). Conclusion: The present study’s finding indicates that the prevalence of CHD in Maharashtra is less compared to the prevalence reported in some other studies worldwide. However, it is a serious problem, which requires immediate attention for the improvement of diagnostic and therapeutic facilities which is accessible to the common man.
Portfólio como estratégia de ensino-aprendizagem em enfermagem: benefícios na graduação
Authors: Szapszay Tess de Oliveira , Nor Gabriela Kereski , Reis Luísa Veber , Neves Charel de Matos , Pedroso Martina Madalena , De Meireles Louisiana Carolina Ferreira , De Rosso Lucas Henrique , Montanari Carolina Caruccio
Published: July 2023

Introdução: O portfólio é uma metodologia de ensino e aprendizagem ativa que reúne os trabalhos realizados durante uma disciplina, visando desenvolver a criticidade e reflexão a partir da prática. Baseado na comunicação dialógica, promove a autonomia e tomada de decisão do estudante, devido ser uma ferramenta estruturada que permite observar os desafios da prática da área de atuação com a capacidade de transformar a dinâmica de aprendizagem. No entanto, evidencia-se a carência de literatura científica que descrevem sua utilização no ensino de Enfermagem. Objetivo: Relatar o uso do portfólio como estratégia de ensino-aprendizagem na graduação em enfermagem. Métodos: Trata-se de um relato de experiência sobre o uso do portfólio na Graduação em Enfermagem da Faculdade de Ciências da Saúde Moinhos de Vento como instrumento avaliativo. A metodologia foi utilizada em duas disciplinas: Assistência de Enfermagem Materno-Infantil e Assistência de Enfermagem ao Paciente Cirúrgico. Em ambas as disciplinas, foi solicitado a construção de portfólios para registro e reflexão sobre as competências trabalhadas em atividades práticas no hospital. Os estudantes receberam as orientações sobre o uso da metodologia em sala de aula e roteiro com pontos a serem observados na prática. Resultados: Na experiência realizada no segundo semestre de 2021, 12 alunos da disciplina assistência de enfermagem materno-infantil e 25 da disciplina de assistência de enfermagem ao paciente cirúrgico foram divididos em grupos de até seis integrantes e realizaram cerca de cinco aulas práticas no hospital em diferentes unidades. Os alunos fizeram observações e registros individualmente a cada dia de prática e entregaram portfólios completos ao final das disciplinas, que foram avaliados e compuseram parte da nota final das disciplinas. Os softwares mais utilizados foram o Microsoft Word e o Canva. A maioria dos estudantes entregou trabalhos de alta qualidade e demonstrou grande dedicação e criatividade, com reflexões críticas e pontos a serem aperfeiçoados. Conclusão: O portfólio mostrou-se uma ferramenta pedagógica eficiente para o desenvolvimento de competências profissionais dos estudantes de Enfermagem. Esta metodologia contribuiu para que os estudantes direcionassem sua atenção a pontos específicos das áreas práticas, sendo reflexivos e críticos diante das suas vivências. Além disso, trata-se de uma ferramenta de fácil aplicabilidade e que possibilita ao docente o acompanhamento do desenvolvimento dos seus objetivos  de aprendizagem  nas disciplinas específicas da Enfermagem.
TRENDS IN THE DEVELOPMENT OF ORGANIC AGRICULTURE IN RUSSIA AGAINST THE BACKGROUND OF GLOBAL TRENDS
Authors: Arkhipova Valentina A.
Published: July 2023

The article analyses the current state of the organic products market in the Russian Federation against the background of global trends. The purpose of this study is to identify trends and prospects for the development of organic agriculture products market in Russia in current geopolitical conditions based on the analysis of its condition and the system of state support. Materials and methods. In the course of the study, reports and materials of the World Organization for Organics (IFOAM), reports and projects of the Organic Farming Union were used. The methods of systemic and statistical analysis, historical and expert assessment methods made it possible to study the current state and development trends of the world and domestic organic markets. Results. The transition to the production of organic food is considered to be one of the modern trends in the development of the world economy. Indicators reflecting the development of the world market of organic agriculture products are increasing every year. Despite the fact that the Russian market of organic products has a small share in the structure of the global organic market, positive trends in its development have been noticeable in recent years: significant growth rates of certified organic land, stabilization of the domestic market volume, increased consumption of organic food. The article summarizes the main instruments for the state regulation of organic producers in the Russian Federation, identifies problems hindering the development of this sector. According to the results of the study, the strategic directions in the development of the organic market in Russia for the nearest future are systematized. Conclusions. Adoption of the Strategy for the Development of Organic Agriculture in Russia should contribute to the entry of the Russian market of organic products to a new competitive level.
BALANCED DEVELOPMENT OF THE REGION AS A SUBJECT OF RISK FACTORS
Authors: Ziganshin Ilchat I. , Serebryakova Tatyana Yu.
Published: July 2023

Balanced development of the regions is currently a vital task, the purpose of which is to improve and equalize the quality of life in all regions, regardless of their natural and technological conditions. The purpose of the article is to study possible risks for the regional economy or, conversely, new opportunities for its development in connection with existing methods of sustainable and balanced regional development. Materials and methods. The materials used in the study are publications of scientists on the problems of balanced regional development, a set of indicators that characterize it. The study used the following methods: systemic and situational approaches, dialectical, logical ones, simulation modeling. Results. The Russian approach to balanced development reflects equality of economic opportunities to meet the social needs of the population in the regions in order to equalize the quality of life and to ensure its equal level throughout the country. It is in this sense that the problem of balancing regional economies should be approached. To identify the risks of imbalance it is proposed to form a region's economic system consisting of five components, all of them are internal ones: 1) the industrial complex; 2) the agro-industrial complex; 3) the socio-demographic complex; 4) the financial and monetary complex; 5) regional management. The system is open and connected with federal components and other regions. The main risk-forming factors are present in the financial component operating both within the system and in external financial interaction. The practical significance of the research results lies in the fact that, based on the proposed formation of a regional economic system, it is possible to identify the risks of its imbalance, taking which into account the system of monitoring financial risks of an unbalanced regional economy is configured. Conclusions. External factors of opportunities in the form of federal transfers make it possible to level the inequality of regions and ensure their sustainable development. It is necessary to assess the impact of this external factor through the effectiveness of regional development and financial security threats.
EXPERIENCE IN THE DEVELOPMENT OF A NATIONWIDE AUTOMATED DATA PROCESSING AND CONTROL SYSTEM AND PROBLEMS OF ITS IMPLEMENTATION IN THE NATIONAL ECONOMY OF THE USSR
Authors: Nazarov Aleksandr A.
Published: July 2023

The review article is devoted to the analysis of the experience in developing a project of a Nationwide automated data processing and control system (OGAS), as well as the problems of its implementation in the national economy of the USSR. It is stated that the emergence of the very idea of OGAS and its subsequent development in the form of computable general equilibrium models (CGE models), dynamic stochastic general equilibrium models (DSGE models) and agent-oriented models are associated with the objective complication of socio-economic relations at all levels, the social nature of production, a high degree of labor differentiation and deep specialization of industries, informatization of production, as well as availability of high-performance computing systems and a widespread use of supercomputer technologies for monitoring, forecasting and planning socio-economic indicators of objects and processes of the world economy, which is reflected in the works of domestic and foreign researchers. Research methods. The main methods were literature analysis, generalization, comparison and systematization of empirical and theoretical data. Results. As the analysis of scientific literature showed, it is possible to distinguish two points of view on defining the main reasons that hindered the development of the OGAS project and resulted in its curtailment. The first point of view is based on the narrative of a "missed chance", and the departmental interest is defined as the main factor. According to the second point of view, one should be critical of the position about unrealized opportunities for the development of Soviet cybernetics, computer technology and computer science and the position about the presence of "milestone" solutions, after which this development abruptly stopped, in addition, the narrative of a "missed chance" does not make it possible to objectively assess the conditions in which this or that historical event took place, and shifts all responsibility for the failure in implementation on to specific administrative structures or persons who made the decision at that time. Conclusions. Despite the fact that the idea of developing and implementing OGAS in the national economic activity of the USSR was progressive and the administrative and command form of management contributed to this, there were still no sufficient objective conditions for its full implementation.