bluuebunny/crossref_metadata_2025 huggingface dataset:
Active Surveillance for Prostate Cancer: Past, Current, and Future Trends
Authors: de Vos Ivo I. , Luiting Henk B. , Roobol Monique J.
Published: April 2023

In response to the rising incidence of indolent, low-risk prostate cancer (PCa) due to increased prostate-specific antigen (PSA) screening in the 1990s, active surveillance (AS) emerged as a treatment modality to combat overtreatment by delaying or avoiding unnecessary definitive treatment and its associated morbidity. AS consists of regular monitoring of PSA levels, digital rectal exams, medical imaging, and prostate biopsies, so that definitive treatment is only offered when deemed necessary. This paper provides a narrative review of the evolution of AS since its inception and an overview of its current landscape and challenges. Although AS was initially only performed in a study setting, numerous studies have provided evidence for the safety and efficacy of AS which has led guidelines to recommend it as a treatment option for patients with low-risk PCa. For intermediate-risk disease, AS appears to be a viable option for those with favourable clinical characteristics. Over the years, the inclusion criteria, follow-up schedule and triggers for definitive treatment have evolved based on the results of various large AS cohorts. Given the burdensome nature of repeat biopsies, risk-based dynamic monitoring may further reduce overtreatment by avoiding repeat biopsies in selected patients.
A Comprehensive Review of IoT Networking Technologies for Smart Home Automation Applications
Authors: Orfanos Vasilios A. , Kaminaris Stavros D. , Papageorgas Panagiotis , Piromalis Dimitrios , Kandris Dionisis
Published: April 2023

The expediential increase in Internet communication technologies leads to its expansion to interests beyond computer networks. MEMS (Micro Electro Mechanical Systems) can now be smaller with higher performance, leading to tiny sensors and actuators with enhanced capabilities. WSN (Wireless Sensor Networks) and IoT (Internet of Things) have become a way for devices to communicate, share their data, and control them remotely. Machine-to-Machine (M2M) scenarios can be easily implemented as the cost of the components needed in that network is now affordable. Some of these solutions seem to be more affordable but lack important features, while other ones provide them but at a higher cost. Furthermore, there are ones that can cover great distances and surpass the limits of a Smart Home, while others are more specialized for operation in small areas. As there is a variety of choices available, a more consolidated view of their characteristics is needed to figure out the pros and cons of each of these technologies. As there are a great number of technologies examined in this paper, they are presented regarding their connectivity: Wired, Wireless, and Dual mode (Wired and Wireless). Their oddities are examined with metrics based on user interaction, technical characteristics, data integrity, and cost factor. In the last part of this article, a comparison of these technologies is presented as an effort to assist home automation users, administrators, or installers in making the right choice among them.
Spatiotemporal Evolution of Soil Erosion and Its Driving Mechanism in the Mongolian Section of the Yellow River Basin
Authors: Tian Tian , Yang Zhenqi , Guo Jianying , Zhang Tiegang , Wang Ziwei , Miao Ping
Published: April 2023

Soil erosion is a popular environmental issue that threatens sustainability. Influenced by multiple factors, such as climate, soil, and terrain, Baotou City, which is in the Bohai Sea Economic Circle and the Economic Belt along the Yellow River, has a severe ecological environment. In this study, revised soil and soil wind erosion equations were used to evaluate the soil erosion dynamics in Baotou City, and the potential driving factors of soil erosion were further investigated. Results showed that from 1990 to 2020, the water erosion modulus in Baotou City increased first, decreased, and then increased, with great fluctuations in annual changes. The wind erosion modulus decreased continuously, with a small fluctuation in annual changes. Water erosion in 2020 was more severe, with 4840.5 km2 added to the desert steppe and 1300.5 km2 reduced in the Yellow River Basin. The extent of wind erosion was significantly reduced, and the phenomenon of wind erosion improved. Meteorological factors are the primary factors that influence soil water erosion and soil wind erosion. Meanwhile, adverse climate changes can alter physical and chemical soil properties and vegetation coverage, thereby indirectly influencing soil erosion. With the implementation of the Beijing–Tianjin sandstorm source control, the farmland return to forest project, the ecological restoration and protection project at the southern and northern foothills of Daqingshan Mountains, grazing prohibition, and rotation grazing—including grassland awards, subsidies, and other policies and systems during this period—the overall deteriorating trend of the grassland ecological environment in Baotou was contained, grassland ecological system functions were improved, wind and sand erosion was prevented, biodiversity was maintained, and the ecological service functions of soil and water conservation were guaranteed.
Spatial Prioritizing Brownfields Catering for Green Infrastructure by Integrating Urban Demands and Site Attributes in a Metropolitan Area
Authors: Feng Shanshan , Shen Jiake , Sheng Shuo , Hu Zengqing , Wang Yuncai
Published: April 2023

Global urbanization and post-industrialization have resulted in the emergence of a large number of brownfields. The integration of brownfields into green infrastructure (GI) has been widely recognized as a sustainable development strategy in metropolitan areas. It is important to spatially prioritize brownfields catering for GI, which can enable the greatest enhancement of urban functions. Various studies have assessed brownfield site attributes or urban demands to define the priority of brownfields transformed into GI, but it is key to consider the coupling coordination between urban demands and site attributes in order to achieve more accurate matches. In this paper, an approach is proposed for assessing the priority of brownfields catering for GI in Xuzhou, China; this involved calculating the coupling coordination degree between site attributes and urban function demands, including heat island mediation, stormwater regulation, disaster prevention, landscape aesthetics improvement, and leisure and recreation increments. The results showed that 42.52% of the brownfields have a high degree of coupling coordination (“good coordination” and “primary coordination”) between site attributes and urban demands. Furthermore, 40.82% of the brownfields (120 plots) were selected to be integrated into urban GI; these are not only located in high urban functional demand areas, but also have a high coupling coordination degree. These brownfields were divided into three priority levels, and 4.42% and 17.69% of the total brownfields are of very high and high priority. Our proposed approach offers an accurate decision-making tool for urban GI optimization in high-density built-up metropolitan areas, and offers guidance for brownfield redevelopment.
Path Modeling between Urban Factors and Happiness of People with Disabilities: Using Partial Least Squares Multi-Group Analysis
Authors: Kim Seong-A , Kim Heungsoon
Published: April 2023

Today, cities place important value on “Sustainable Cities” and “Cities for all”, concepts which mean that consideration for people with disabilities has become an essential element in urban planning and development. Moreover, the number of people with disabilities living in cities is steadily growing. In this context, the purpose of this study was to compare the happiness levels of people with and without disabilities living in Seoul, using the Seoul Survey data provided by the Seoul Metropolitan Government, and to identify a structural model of urban factors that affect the happiness of people with disabilities. Under this purpose, a partial least squares multi-group analysis (PLS-MGA) was conducted by setting up an analysis model (disabled group) and a contrasting model (non-disabled group) to determine differences between the groups (disabled and non-disabled). The results of the analysis were as follows. First, unlike in the non-disabled group, in which all factors had a significant effect on the levels of happiness, only a few factors were significant in the disabled group (the private, residential, and culture and leisure characteristics were not significant). Second, compared to the non-disabled group, social capital, urban safety, and living environment satisfaction were more important than personal attributes in the disabled group. Third, the relationship between the happiness levels of people with disabilities and urban factors was multidimensional rather than unidimensional. Fourth, the two groups differed in their structural models and pathways, and the differences were statistically significant. The present study made significant academic and policy contributions as it investigated the levels of happiness of people with disabilities living in the city and their perceptions of the city and used PLS-MGA to identify the multidimensional relationship between urban factors and happiness level.
Bone Disease in Long-Term Lung Transplant Survivors
Authors: Grassi Giorgia , Cairoli Elisa , Gentile Lucrezia Maria Silvana , Chiodini Iacopo , Zampogna Marta , Ghielmetti Alberto , Morlacchi Letizia Corinna , Rossetti Valeria , Rosso Lorenzo , Righi Ilaria , Nosotti Mario , Arosio Maura , Blasi Francesco , Eller Vainicher Cristina
Published: April 2023

Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our study is to compare the skeletal outcomes, after the first 2 years post-LTx, in long-term survivors with CF and nCF. Materials and Methods: We evaluated the FX rate, the changes in bone mineral density (BMD) and trabecular bone score (TBS) in 68 patients (38 CF and 30 nCF) who underwent LTx in our center and with a follow-up after LTx longer than 5 years (7.3 ± 2.0 years). Results: After the second year post-LTx: (i) the FX rate was lower than during the first two years post-LTx (4.4 vs. 20.6%, p = 0.004), with no difference between CF and nCF patients (5.3 vs. 3.3%, p = 0.589); (ii) BMD at lumbar spine, femoral neck and total hip remained stable (−1.6 ± 1.0 vs. −1.4 ± 1.1, p = 0.431, −1.8 ± 0.9 vs. −1.9 ± 0.9, p = 0.683, −1.5 ± 0.9 vs. −1.4 ± 0.9, p = 0.678, respectively) as well as TBS (1.200 ± 0.124 vs. 1.199 ± 0.205, p = 0.166). Conclusions: After the second year post-LTx, the skeletal complications become less frequent and have similar incidence in patients with CF and nCF.
Predictors of Significant Liver Fibrosis in People with Chronic Hepatitis C Who Inject Drugs in the Czech Republic
Authors: Frankova Sona , Uzlova Nikola , Merta Dusan , Pitova Veronika , Sperl Jan
Published: April 2023

Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID starting anti-HCV therapy and identify the factors associated with severe fibrosis. Methods: The cohort of 200 patients was divided into two groups: F0–F2 (N = 154, 77%), patients with liver stiffness measurement (LSM) < 10.0 kPa, and F3–F4 (N = 46, 23%), with LSM ≥ 10.0 kPa, indicating significant liver fibrosis. Results: In group F3–F4, there were significantly more males, and the patients were older, with a higher BMI. The number of long-term abstaining patients was significantly higher in group F3–F4 compared with group F0–F2, as well as the proportion of patients reporting harmful drinking. Obesity (OR 4.77), long-term abstinence from illicit drugs (OR 4.06), harmful drinking (OR 2.83), and older age (OR 1.17) were significant predictors of advanced fibrosis in PWID starting anti-HCV therapy. Conclusions: A quarter of PWID presented with significant liver fibrosis at treatment initiation. Obesity, long-term drug abstinence, harmful drinking, and older age contributed to significant liver fibrosis.
Inhibitory Effects of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae on Tyrosinase Activity and α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells
Authors: Choosuwan Pradtana , Praiboon Jantana , Boonpisuttinant Korawinwich , Klomjit Anirut , Muangmai Narongrit , Ruangchuay Rapeeporn , Chirapart Anong
Published: April 2023

Melanogenesis involves a synthesis of melanin pigment and is regulated by tyrosinase. The addition of whitening agents with tyrosinase-inhibiting properties in cosmetics is becoming increasingly important. In this study, the ethanolic extracts from twelve seaweeds were assessed for tyrosinase-inhibiting activity using mushroom tyrosinase and melanin synthesis in B16F10 melanoma cells. The highest mushroom tyrosinase inhibition (IC50) was observed with Lobophora challengeriae (0.15 ± 0.01 mg mL−1); treatment was more effective than kojic acid (IC50 = 0.35 ± 0.05 mg mL−1), a well-known tyrosinase inhibitor. Three seaweeds, Caulerpa racemosa, Ulva intestinalis, and L. challengeriae, were further investigated for their ability to reduce melanogenesis in B16F10 cells. The ethanolic extracts of C. racemosa, U. intestinalis, and L. challengeriae showed inhibitory effects by reducing melanin and intracellular tyrosinase levels in B16F10 cells treated with α-melanocyte stimulating hormone in a dose-dependent manner. C. racemosa (33.71%) and L. challengeriae (36.14%) at 25 µg mL−1 reduced melanin production comparable to that of kojic acid (36.18%). L. challengeriae showed a stronger inhibition of intracellular tyrosinase (decreased from 165.23% to 46.30%) than kojic acid (to 72.50%). Thus, ethanolic extracts from C. racemosa, U. intestinalis, and L. challengeriae can be good sources of natural tyrosinase inhibitors and therapeutic or cosmetic agents in the future.
Learning Curve of Real-Time Imaging with C-Arm Based Tomography for Peripheral Lung Nodule Biopsy
Authors: Senyei Grant , Nobari Matthew , Miller Russell , Harrell Brody , Cheng George Z.
Published: April 2023

The number of procedures required to attain proficiency with new bronchoscopic biopsy technologies for peripheral pulmonary lesions (PPLs) is uncertain. A prospective, single-center study evaluated learning curves of two operators performing PPL biopsies using a novel, real-time, intraoperative tomographic imaging system in consecutive procedures in adults with CT-detected PPLs. Operators were considered “proficient” when they asked three or fewer questions of the manufacturer’s clinical representative with no subsequent navigations in which they asked more than three questions. A total of 31 procedures were performed on 31 patients (Operator 1: 18, Operator 2: 13). Proficiency was achieved after an average of 10 procedures (Operator 1: 12, Operator 2: 8). From the learning curve to the post-learning curve period, the number of questions (median [IQR]: 23 [9.5–41.5] versus 0 [0–1], p < 0.001) and radiation dose (median [IQR]: 19.5 mGy/m2 [1.9–43.5] versus 1.5 mGy/m2 [0.7–3.3], p = 0.05) decreased significantly; procedure time decreased (median [IQR]: 12 min [7–20] versus 8 min [3–15], p = 0.29); and diagnostic yield increased significantly (13/20 cases [65%] to 11/11 cases [100%]), (p = 0.03). Based on this unique, clinically relevant method of assessing learning curve, proficiency with the Body Vision system was achieved at approximately the tenth procedure. These findings require validation in larger, diverse populations.
A Comparative Review of Air Drones (UAVs) and Delivery Bots (SUGVs) for Automated Last Mile Home Delivery
Authors: Li Fang , Kunze Oliver
Published: April 2023

Background: UAVs (Unmanned Aerial Vehicles) and SUGVs (Sidewalk Unmanned Ground Vehicles) are two prominent options to revolutionize last mile home delivery. However, there is no literature yet addressing a comprehensive assessment of them. To bridge this research gap, this paper aimed to compare UAVs to SUGVs in the context of urban parcel delivery from a practical, conceptual, technological, commercial, and environmental perspective. Methodology: Based on structured literature and web research, this paper provided a comparative status quo review of these two delivery concepts. We introduced a parameter-based cost calculus model to estimate the costs per shipment for each technology. To detect the key cost drivers, we applied a one-way sensitivity analysis, as well as a “full factorial design of experiment” approach. Results: These key cost drivers for both operations are the “number of vehicles per operator” and the “average beeline service radius”. From today’s commercial point of view, our model indicated better profitability of SUGVs. However, technical and regulatory developments may render different results in the future. As SUGVs emit significantly less noise than UAVs, we assume that SUGVs have an additional advantage for usage in autonomous urban last mile delivery from a resident’s perspective. Conclusions: Both key cost drivers will significantly influence the commercial viability of unmanned home delivery services. Safety and security aspects will determine regulatory rules on “number of vehicles per operator”. To increase the “average beeline service radius”, UAVs could profit from mothership delivery concepts while SUGV delivery may co-use existing public transport infrastructure.
A Study on the Thermal Properties of Oil-Film Viscosity in Squeeze Film Dampers
Authors: Zhou Hailun , Cao Gangyi , Chen Xi , Zhang Yuqi , Cang Yangguang
Published: April 2023

Considering the variation in temperature of the oil film in squeeze film dampers (SFDs) caused by squeezing, a more comprehensive analysis of SFD can be obtained. Aiming to investigate the viscosity thermal effect of the oil film in SFDs, this study established a 3D CFD solution model. Based on the total energy model, the viscosity thermal effect was performed. With the mixture multi–phase flow model, the Zwart–Gerber–Belamri (Z–G–B) cavitation model, and the use of the additional mass coefficient, the two–phase flow phenomenon in SFDs was discussed. The oil film at various temperatures and the temperature distribution of different oil types under different working conditions were analyzed. Furthermore, the influence of the SFD thermal effect on the two–phase flow phenomenon were particularly carried out. Meanwhile, the simulation results of the SFD thermal effect were experimentally verified. The results revealed that the maximum temperature of the SFD oil film was enhanced with the increase in the eccentricity ratio and precession frequency. The temperature of the oil film was closely related to the oil dynamic viscosity. The dynamic viscosity of the oil was reduced, which was caused by the SFD thermal effect, thus leading to decreased oil–film damping, enlarging the vaporization level and the range of vapor cavitation, as well as the ingested air amount. CFD simulation results of the thermal effect were in good agreement with the experimental data, which verified the accuracy of the proposed model.
A New Single-Leg Lower-Limb Rehabilitation Robot: Design, Analysis and Experimental Evaluation
Authors: Yu Hongfei , Zheng Siyuan , Wu Jiantao , Sun Li , Chen Yongliang , Zhang Shuo , Qin Zhongzhi
Published: April 2023

Conventional lower-limb rehabilitation robots are large, complicated to wear, and require moving the patient to a designated position. To solve these problems, a new single-legged lower-limb rehabilitation robot (S-LLRR) that is easy to move and suitable for different height carriers was proposed. The mechanical leg has a variable working space, and its rotating joints are designed with mechanical limiters. The series configuration of the S-LLRR was analyzed, and trajectory planning was performed based on continuous linear motion training. Meanwhile, an active training control method based on the sand model was proposed to enhance the motion sensation of patients, and an active participation degree evaluation model was designed based on human physiological information. The simulation and experimental results showed that S-LLRR had a large workspace and good motion accuracy, and the accuracy of the active participation degree evaluation model could reach more than 85%. This research could provide a theoretical basis for improving the standardization and compliance of lower-limb robot rehabilitation training.
Induction Motor Noise Source Separation and Identification Based on Adaptive Scale-Space Mode Extraction
Authors: Wang Zhengqi , Gu Yanling , Chen Changzheng , Wang Lipeng , Sun Xianming
Published: April 2023

Separating induction motor noise sources can provide an important reference basis for induction motor condition detection, noise reduction treatment, and fault diagnosis. Induction motors have different types of noise sources that partially overlap, and most radiate outward through the housing, so it is difficult to separate these noise sources. Therefore, a single-channel induction motor noise source separation and identification method, based on adaptive scale-space modal extraction (ASSME) is proposed. Firstly, the adaptive scale-space mode extraction method is proposed by constructing the electromagnetic feature scale space and the adaptive penalty factor. The simulation results show that this method solves over-decomposition problems in the classical scale-space variational mode decomposition and the difficulty in balancing the harmonic and shock modes. Secondly, motor noise experiments are conducted to construct blind source separation multi-channel inputs using the adaptive scale-space modal extraction method, judging the validity of the modal components using correlation and the variance contribution rate. Finally, robust independent component analysis (RobustICA) is used to extract independent noise components and identify these noise sources by power spectral density and envelope analysis. The results show that the multi-channel input signals obtained by the proposed method are more accurate and practical than those obtained by other methods. The independent components extracted through this noise source separation method are: electromagnetic noise of different orders, aerodynamic noise, and switching frequency noise.
Investigation of Cubic and Spherical IONPs’ Rheological Characteristics and Aggregation Patterns from the Perspective of Magnetic Targeting
Authors: Ioncica Maria-Cristina , Bandyopadhyay Sulalit , Bali Nesrine , Socoliuc Vlad , Bernad Sandor I.
Published: April 2023

Based on our prior research, we synthesized iron-oxide nanoparticles (IONPs) in two shapes (spherical and cubic) and sized them for the current inquiry. This research examined the magnetic, rheological, and sedimentation properties of the suspensions containing PEG-coated IONPs, considering that both produced particles are intended to be employed for magnetic targeting applications. The saturation magnetization of both IONPs was lower than the magnetite domain magnetization of 92 emu/g due to the surfactant and the dead surface magnetic layer. Under each investigated magnetic field (0, 34 and 183 mT), the shear viscosity behaviour of the MNP suspensions of both kinds was comparable. Shear thinning behaviour was seen for both particle suspensions in the low shear rate area (0.1 s−1 to 1 s−1). The rheological curves from this paper show that the suspensions present a higher viscosity at lower shear rates for spherical and cubic PEG-coated nanoparticles when a magnetic field is applied. The aggregation behaviour demonstrates that cubic-shaped IONPs are more stable throughout time, with hydrodynamic diameter measurements showing a relatively slow variation of the DLS size distribution from 250 nm to 210 nm in the first 600 s; contrarily, the hydrodynamic diameter of spherical IONPs fluctuated significantly, from 855 nm to 460 nm. Another key finding relates to the sedimentation profile, specifically that PEG-coated IONPs with spherical shapes have a stronger tendency to sediment than those with cubic forms, which are more stable.
Global Dynamics for Competition between Two Wolbachia Strains with Bidirectional Cytoplasmic Incompatibility
Authors: Huang Qiming , Chang Lijie , Zhang Zhaowang , Zheng Bo
Published: April 2023

Releasing Wolbachia-infected mosquitoes to suppress or replace wild vector mosquitoes has been carried out in 24 countries worldwide, showing great promise in controlling mosquitoes and mosquito-borne diseases. To face the instability of Wolbachia infection in different environments during the area-wide application, we should consider the overlapping of two Wolbachia strains. In this case, bidirectional cytoplasmic incompatibility occurs, which results in mating partners infected with exclusive Wolbachia strains producing inviable offspring. To determine the better Wolbachia candidate for release, we develop an ordinary differential equation model to study the global dynamics for competition between two Wolbachia strains. Our theoretical results on the sharp estimate of stable curves completely determine the fate of the two Wolbachia strains, which help choose appropriate strains for release.
LCAM: Low-Complexity Attention Module for Lightweight Face Recognition Networks
Authors: Hoo Seng Chun , Ibrahim Haidi , Suandi Shahrel Azmin , Ng Theam Foo
Published: April 2023

Inspired by the human visual system to concentrate on the important region of a scene, attention modules recalibrate the weights of either the channel features alone or along with spatial features to prioritize informative regions while suppressing unimportant information. However, the floating-point operations (FLOPs) and parameter counts are considerably high when one is incorporating these modules, especially for those with both channel and spatial attentions in a baseline model. Despite the success of attention modules in general ImageNet classification tasks, emphasis should be given to incorporating these modules in face recognition tasks. Hence, a novel attention mechanism with three parallel branches known as the Low-Complexity Attention Module (LCAM) is proposed. Note that there is only one convolution operation for each branch. Therefore, the LCAM is lightweight, yet it is still able to achieve a better performance. Experiments from face verification tasks indicate that LCAM achieves similar or even better results compared with those of previous modules that incorporate both channel and spatial attentions. Moreover, compared to the baseline model with no attention modules, LCAM achieves performance values of 0.84% on ConvFaceNeXt, 1.15% on MobileFaceNet, and 0.86% on ProxylessFaceNAS with respect to the average accuracy of seven image-based face recognition datasets.
Does the Rechallenge with Another CDK 4/6 Inhibitor in Breast Cancer Work? A Case Report and Literature Review
Authors: Stanciu Ioana-Miruna , Pirlog Cristina Florina , Anghel Andrei-Wilhelm , Parosanu Andreea Ioana , Olaru Cristina Mihaela , Orlov-Slavu Cristina , Iaciu Ion Cristian , Popa Ana Maria , Vrabie Radu Constantin , Nitipir Cornelia
Published: April 2023

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors and endocrine therapy are the gold standards for systemic therapy for patients with hormone-positive (HR+)/human epidermal growth factor receptor-2-negative (HER2-) metastatic breast cancer. Following progression, no prospective randomized data exist to help guide second-line treatment. Moreover, there is a scarcity of data on rechallenge treatment strategies with another CDK4/6 inhibitor after prior limiting toxicity. We report a real-world experience of rechallenging with abemaciclib after the prior reaction of grade 4 liver toxicity to ribociclib, with high transaminases values of more than 27 times the upper limit of normal (ULN) and unexpected grade 3 neutropenia and diarrhea after a few months of abemaciclib. After two years of treatment, the patient had stable oncological disease, with normal complete blood count, hepatic enzymes, and a very good performance status. We believe that our clinical case, along with others gathered from all around the world, will help with the consolidation of an unmet clinical need to readjust the treatment after experiencing toxicity to CDK4/6 inhibitors.
Revealing the Formation of Recast Layer around the Film Cooling Hole in Superalloys Fabricated Using Electrical Discharge Machining
Authors: Yang Zenan , Liu Lu , Wang Jianbin , Xu Junjie , Zhao Wanrong , Zhou Liyuan , He Feng , Wang Zhijun
Published: April 2023

A film cooling hole is an efficient and reliable cooling method, which is widely used in aeroengine turbine blades to effectively improve the thrust–weight ratio of the engine. Electrical discharge machining is the most common manufacturing process for film cooling holes. Due to the rapid quenching after high-temperature melting, a certain thickness of the recast layer will be formed in the vicinity of the hole wall. The microstructure of the recast layer is considered to be an important factor affecting the performance of single-crystal blades. Generally, the recast layer has been thought of as one of the main reasons for the failure of turbine blades. Accordingly, the formation of the recast layer is an important and interesting issue to be revealed. In this work, the recast layer formed using electrical discharge machining on a single-crystal superalloy is studied with TEM. It is found that the recast layer is in the state of supersaturated solution with a single-crystal structure epitaxially grown from the matrix, and many dislocations were observed therein.
Special Issue “SARS-CoV-2: Epidemiology and Pathogenesis”: Editorial
Authors: Calistri Paolo , Gill Harsharn , Lorusso Alessio
Published: April 2023

Since its emergence in 2019 in Wuhan City, Hubei Province, China, SARS-CoV-2 has spread across hundreds of countries and all continents [...]
A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
Authors: Lim Sooa
Published: April 2023

The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species.
Thermal Rearrangement of 5-(2-Hydroxy-6-oxocyclohexyl)-5H-chromeno[2,3-b]pyridines
Authors: Ryzhkova Yuliya E. , Ryzhkov Fedor V. , Elinson Michail N. , Vereshchagin Anatoly N. , Novikov Roman A. , Fakhrutdinov Artem N.
Published: April 2023

Some of the most important transformations in organic chemistry are rearrangement reactions, which play a crucial role in increasing synthetic efficiency and molecular complexity. The development of synthetic strategies involving rearrangement reactions, which can accomplish synthetic goals in a very efficient manner, has been an evergreen topic in the synthetic chemistry community. Xanthenes, pyridin-2(1H)-ones, and 1,6-naphthyridines have a wide range of biological activities. In this work, we propose the thermal rearrangement of 7,9-dihalogen-substituted 5-(2-hydroxy-6-oxocyclohexyl)-5H-chromeno[2,3-b]pyridines in DMSO. Previously unknown 5,7-dihalogenated 5-(2,3,4,9-tetrahydro-1H-xanthen-9-yl)-6-oxo-1,6-dihydropyridines and 10-(3,5-dihalogen-2-hydroxyphenyl)-5,6,7,8,9,10-hexahydrobenzo[b][1,6]naphthyridines were synthesized with excellent yields (90–99%). The investigation of the transformation using 1H-NMR monitoring made it possible to confirm the ANRORC mechanism. The structures of synthesized compounds were confirmed by 2D-NMR spectroscopy.
Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders
Authors: Osman Ahmed G. , Avula Bharathi , Katragunta Kumar , Ali Zulfiqar , Chittiboyina Amar G. , Khan Ikhlas A.
Published: April 2023

Elderberry is highly reputed for its health-improving effects. Multiple pieces of evidence indicate that the consumption of berries is linked to enhancing human health and preventing or delaying the onset of chronic medical conditions. Compared with other fruit, elderberry is a very rich source of anthocyanins (approximately 80% of the polyphenol content). These polyphenols are the principals that essentially contribute to the high antioxidant and anti-inflammatory capacities and the health benefits of elderberry fruit extract. These health effects include attenuation of cardiovascular, neurodegenerative, and inflammatory disorders, as well as anti-diabetic, anticancer, antiviral, and immuno-stimulatory effects. Sales of elderberry supplements skyrocketed to $320 million over the year 2020, according to an American Botanical Council (ABC) report, which is attributable to the purported immune-enhancing effects of elderberry. In the current review, the chemical composition of the polyphenolic content of the European elderberry (Sambucus nigra) and the American elderberry (Sambucus canadensis), as well as the analytical techniques employed to analyze, characterize, and ascertain the chemical consistency will be addressed. Further, the factors that influence the consistency of the polyphenolic chemical composition, and hence, the consistency of the health benefits of elderberry extracts will be presented. Additionally, adulteration and safety as factors contributing to consistency will be covered. The role of elderberry in enhancing human health alone with the pharmacological basis, the cellular pathways, and the molecular mechanisms underlying the observed health benefits of elderberry fruit extracts will be also reviewed.
Fabrication of Ternary MoS2/CdS/Bi2S3-Based Nano Composites for Photocatalytic Dye Degradation
Authors: Nazir Asif , Tahir Muhammad Suleman , Kamal Ghulam Mustafa , Zhang Xu , Tahir Muhammad Bilal , Jiang Bin , Safdar Muhammad
Published: April 2023

The synthesis and design of low-cost visible-light-active catalysts for the photodegradation of organic dyes have been regarded as an efficient way to use solar energy in addressing environmental issues. We report the fabrication of MoS2/CdS nanoparticles functionalized with Bi2S3 nanoflakes. The ternary composites of “MoS2/CdS/Bi2S3” were synthesized in situ by a hydrothermal method at different temperatures. The changes in structural, optical, and morphological properties of the synthesized CdS/MoS2/Bi2S3 were explored. The effects of Bi2S3 on CdS/MoS2 were thoroughly studied by performing an X-ray diffractometer (XRD), a scanning electron microscope (SEM), an ultra-violet–visible spectrometer (Uv–vis), and Fourier transform infrared spectroscopic (FT-IR) studies of the nanoparticles. XRD confirms the cubical crystal structure of the nanoparticles. SEM studies possess the modulation in the surface morphology with the tenability in volume ratios of “MoS2/CdS/Bi2S3” composites. It was observed that the bandgaps calculated using absorption measurements could be manipulated from 2.40 eV to 0.97 eV with varying Bi2S3 in the MoS2/CdS nanostructures. FT-IR confirmed the synthesis of “MoS2/CdS/Bi2S3” nanoparticles. On allowing the visible light to fall for 120 min, it was observed that “MoS2/CdS/Bi2S3” degrades the methylene blue up to 90%. The calculated results of “MoS2/CdS/Bi2S3” suggest that the synthesized material could be a strong candidate for photodegradation applications. This research work explains the synthesis of MoS2/CdS/Bi2S3-based nanocomposites for the degradation of dye using a photocatalytic process. The final results show that this catalyst effectively degrades the dye.
The Facet Dependence of CO2 Electroreduction Selectivity on a Pd3Au Bimetallic Catalyst: A DFT Study
Authors: Zheng Ming , Zhou Xin , Wang Yixin , Chen Gang , Li Mingxia
Published: April 2023

The electrochemical carbon dioxide reduction reaction (CO2RR) has emerged as a promising approach to addressing global energy and environmental challenges. Alloys are of particular importance in these applications due to their unique chemical and physical properties. In this study, the possible mechanism of the C1 products from the electrochemical reduction of CO2 on four different surfaces of Pd3Au alloy bimetallic catalysts is predicted using the density functional theory. The differences in the number of d-band electrons and the charge distribution and morphology of the different surfaces result in differing catalytic activity and selectivity on the same surface. On different surfaces, Pd3Au alloy bimetallic catalysts have different potential limiting steps in CO2RR, resulting in differing selectivity. The Pd3Au (100) surface has a good selectivity for HER, indicating that the increase in the net charge on the surface of the alloy improves the selectivity for HER. The Pd3Au (211) surface, with a step structure, shows a good selectivity for methanol production from CO2RR. In addition, an electronic structure analysis shows that the selectivity of the reactions involved in the conversion of adsorbates is determined by the difference between the center of the d-band on the top of the catalyst, where the reactant and the product are located. The results of this study may provide some theoretical basis for designing and developing more efficient and selective CO2 reduction catalysts.
Atropostatin: Design and Total Synthesis of an Atropisomeric Lactone–Atorvastatin Prodrug
Authors: Pecorari Daniel , Mazzanti Andrea , Mancinelli Michele
Published: April 2023

Atorvastatins play an important role in the inhibition of HMG-CoA reductase, an enzyme present in the liver that takes part in the biosynthesis of cholesterol. In this article, we report the total synthesis of a lactone–atorvastatin prodrug with additional atropisomeric features. Conformational and experimental studies of model compounds were designed to test the stability of the chiral axis. Docking calculations were performed to evaluate the constant inhibition of a library of atorvastatins. Full synthesis of the best candidate was achieved and thermally stable atropisomeric lactone–atorvastatin was obtained. The absolute configuration of the chiral axis of the atropisomers was assigned by means of chiroptical ECD spectroscopy coupled with TD-DFT calculations.
An Efficient Method of Pennisetum × advena ‘Rubrum’ Plantlets Production Using the Temporary Immersion Bioreactor Systems and Agar Cultures
Authors: Pożoga Mariusz , Olewnicki Dawid , Wójcik-Gront Elżbieta , Latocha Piotr
Published: April 2023

The aim of this study is to develop an efficient method for micropropagation of Pennisetum × advena ‘Rubrum’. Agar cultures containing Murashige and Skoog (MS) medium supplemented with 6-benzyl-amino-purine (BAP) in various concentrations (0.5 mg/L to 2 mg/L) and a temporary immersion bioreactor system (TIS) using liquid medium MS with an addition of 1 mg/L BAP were tested. Rooting was performed using ½ MS medium supplemented with different auxin combinations (indole-3-butyric acid IBA and α-naphthalene acetic acid NAA) and activated charcoal. The TIS method was found to be the most efficient, producing 36.9 new plants within four weeks. The resulting plantlets were thin and bright green in color, with no signs of hyperhydricity. The most suitable agar medium yielded 19.5 new plants within eight weeks. For rooting, ½ MS supplemented with 0.5 mg/L IBA and 0.5 mg/L NAA exhibited an 84% rooting rate, whereas the addition of activated charcoal inhibited rooting.
The Bacterial Volatile Organic Compound N,N-Dimethylhexadecylamine Induces Long-Lasting Developmental and Immune Responses throughout The Life Cycle of Arabidopsis thaliana
Authors: Hernández-Soberano Christian , López-Bucio José , Valencia-Cantero Eduardo
Published: April 2023

N,N-dimethylhexadecylamine (DMHDA) is a bacterial volatile organic compound that affects plant growth and morphogenesis and is considered a cross-kingdom signal molecule. Its bioactivity involves crosstalk with the cytokinin and jasmonic acid (JA) pathways to control stem cell niches and induce iron deficiency adaptation and plant defense. In this study, through genetic analysis, we show that the DMHDA-JA-Ethylene (ET) relations determine the magnitude of the defensive response mounted during the infestation of Arabidopsis plants by the pathogenic fungus Botrytis cinerea. The Arabidopsis mutants defective in the JA receptor CORONATINE INSENSITIVE 1 (coi1-1) showed a more severe infestation when compared to wild-type plants (Col-0) that were partially restored by DMHDA supplements. Moreover, the oversensitivity manifested by ETHYLENE INSENSITIVE 2 (ein2) by B. cinerea infestation could not be reverted by the volatile, suggesting a role for this gene in DMHDA reinforcement of immunity. Growth of Col-0 plants was inhibited by DMHDA, but ein2 did not. Noteworthy, Arabidopsis seeds treated with DMHDA produced more vigorous plants throughout their life cycle. These data are supportive of a scenario where plant perception of a bacterial volatile influences the resistance to a fungal phytopathogen while modulating plant growth.
Recent Approaches to the Modification of Collagen Biomatrix as a Corneal Biomatrix and Its Cellular Interaction
Authors: Ra’oh Nur Amalia , Man Rohaina Che , Fauzi Mh Busra , Ghafar Norzana Abd , Buyong Muhamad Ramdzan , Hwei Ng Min , Halim Wan Haslina Wan Abdul
Published: April 2023

Over the last several decades, numerous modifications and advancements have been made to design the optimal corneal biomatrix for corneal epithelial cell (CECs) or limbal epithelial stem cell (LESC) carriers. However, researchers have yet to discover the ideal optimization strategies for corneal biomatrix design and its effects on cultured CECs or LESCs. This review discusses and summarizes recent optimization strategies for developing an ideal collagen biomatrix and its interactions with CECs and LESCs. Using PRISMA guidelines, articles published from June 2012 to June 2022 were systematically searched using Web of Science (WoS), Scopus, PubMed, Wiley, and EBSCOhost databases. The literature search identified 444 potential relevant published articles, with 29 relevant articles selected based on inclusion and exclusion criteria following screening and appraising processes. Physicochemical and biocompatibility (in vitro and in vivo) characterization methods are highlighted, which are inconsistent throughout various studies. Despite the variability in the methodology approach, it is postulated that the modification of the collagen biomatrix improves its mechanical and biocompatibility properties toward CECs and LESCs. All findings are discussed in this review, which provides a general view of recent trends in this field.
Blood Parameters, Kidney Histology and Growth Performances in Gallus gallus Domesticus (Brahma) Hens Fed a Diet Supplemented with Dacryodes edulis (Safou) Powder Leaves
Authors: Tchoffo Herve , Ngwemetah Nathalie , Atsamo Donatien Albert , Momo Chongsi Margaret Mary , Djoukouo Signe Christelle Yolande , Kambou Blandine , Dongmo Arius Baulland Nguedia , Motchewo Nadege Djuissi , Ngoula Ferdinand
Published: April 2023

The leaf extracts of Dacryodes edulis possess high concentrations of alkaloids, saponins, flavonoids, and tannins with various biological activities, including antimicrobial, antifungal, and antioxidant activities. These activities can be used in animal production to avoid the energy lost in favor of growth and reproduction. A total of 48 Brahma hens (45 days old), weighing on average 400 ± 12 g, were randomly distributed into four dietary treatment groups (12 birds each) with four replicates per group. The control group (T0) received 0% D. edulis, while the three test groups (T0.25, T0.50, and T0.75) were given feed with D. edulis powder leaves at concentrations of 0.25, 0.5, and 0.75%, respectively, for a period of 60 days. Water and feed were supplied ad libitum. At the end of the study period (60 days), eight birds per treatment (two per replicate) were fasted, weighed, and slaughtered. Blood samples and organs were collected for analysis of growth characteristics, oxidative stress, and toxicity indices. This study revealed a significant (p < 0.05) increase in feed intake and live body weight with 0.75% D. edilus powder leaves. Abdominal fat was found to be significantly (p < 0.05) lower with 0.75% D. edilus powder leaves compared to the control group. Serum Aspartate aminotransferase activity was significantly (p < 0.05) lower in birds exposed to 0.75% D. edulis leaf powder compared to the control group. The use of D. edulis leaf powder as feed additive in feed could reduce oxidative stress and improve growth performance in Brahma. More research can be conducted on D. edilus, and it can be used in broiler feed at 0.75% concentration, which has shown a significant increase and decrease, respectively, in live body weight and serum aspartate aminotransferase activity.
Study on Estimation Method of Enthalpy of Evaporation Based on Elements and Chemical Bonds
Authors: Pan Yule , Ma Wenjiao , Niu Baowei , Li Xinyu , Xiang Shuguang , Xia Li
Published: April 2023

A new Group Contribution Method based on elements and chemical bonds was proposed to predict the enthalpy of evaporation of organic compounds at their normal boiling points. A prediction model was built using 1266 experimental data points, and the accuracy of the model estimations was evaluated using 16 experimental data points. The new method has only 42 groups, a simple way of group splitting, and a wide range of predictions with an average relative error of 5.84%. Furthermore, the inclusion of silicon elements and their chemical bonds in the group library enables the effective prediction of silicon-containing compounds with an average relative error of 2.71%. By analyzing and comparing the other three commonly used methods, it can be concluded that the new method provides accurate and reliable estimation results and has a more comprehensive application range.