bluuebunny/crossref_metadata_2025 huggingface dataset:
Kayseri Organize Sanayi Bölgesi Atıksu Arıtma Tesisinde Tasarım ve Mevcut Durum Karşılaştırması
Authors: KARAKAYA Mehmet , DULKADİROĞLU Hakan
Published: December 2021

Organize Sanayi Bölgeleri (OSB)’nde atıksu arıtma tesisinin projelendirilmesi aşamasında genellikle kapasite doluluk oranı düşük olmakta ve boşlukların hangi sektörden, kaç işletme ile doldurulacağı belli olmamaktadır. Ölçümlerle ya da benzer örneklere göre belirlenen atıksu miktar ve özellikleri, OSB doluluk olarak tam kapasiteye ulaştığında ve/veya işletmelerde değişiklikler olduğunda değişebilmekte ve deşarj limitlerinin sağlanmasında sorun yaşanabilmektedir. Bu çalışmada, OSB’lerde ortak atıksu arıtma tesislerinin proje aşamasında esas alınan atıksu miktar ve özelliklerinin zamanla işletme sayı ve sektörlerine bağlı olarak değişimi ve bunun arıtma tesisi performansı üzerine etkileri Kayseri OSB örneği üzerinden incelenmiştir. 1999’da kurulan bölgede özellikle 2013 sonrasında önemli gelişme sağlanmış, 353 olan toplam işletme sayısı 2017 yılında 1165’e yükselmiştir. Bununla birlikte, tasarımda ilk etap için 40.000 m3/gün olarak esas alınan debi değerine henüz ulaşılmadığı ve mevcut debinin 28.000 – 30.000 m3/gün aralığında değiştiği, atıksu karakterizasyonu için de 2008’de tespit edilen değerlerin son 5,5 yılda ölçülen değerlerle büyük oranda uyumlu olduğu görülmüştür. Dolayısıyla deşarj limitlerinin sağlanmasında herhangi bir sorun yaşanmamaktadır.
Du pareil au même
Authors: BARRY Laurent
Published: December 2021

Dans Les deux sœurs et leur mère, Françoise Héritier propose un nouveau modèle explicatif de certains interdits incestueux entre alliés fondé sur une compréhension nouvelle de l’institution de la prohibition de l’inceste. Plutôt- que de reposer sur une volonté d’ouvrir le champ matrimonial à d’autres groupes, comme le voulait Claude Lévi-Strauss, cette dernière viserait à réguler en interne la tension existant au sein de la communauté elle-même entre identité et altérité. L’attitude du groupe vis-à-vis de la mise en contact du même expliquerait alors non seulement ces interdits du « deuxième type » entre affins, mais aussi par extension selon Françoise Héritier les interdits entre consanguins, englobant ce faisant l’ensemble des prohibitions incestueuses. L’auteur se penche ici sur ces propositions, montrant que, nonobstant l’originalité indéniable de cette hypothèse, sa logique interne ne lui permet pas logiquement d’expliquer les interdits consanguins du « premier type » et donc de transcender le cercle restreint des interdits entre alliés sur laquelle elle fut fondée à l’origine.
EFFECT OF HEAT TREATMENT ON THE MICROSTRUCTURE AND PERFORMANCE OF HIGH-VELOCITY AIR-FUEL SPRAYED WC-10Co4Cr COATINGS
Authors: Xue Yong , Zhou Xuedong , Liu Haijun , Zhang Jishi , Ji Jinsheng , Zhao Wensheng , Zhang Zhimin , Wang Qiang
Published: December 2021

In this study a high-velocity air-fuel (HVAF) flame-sprayed WC-10Co4Cr coating was heat-treated at (240; 300; 400) °C for 2 h in an air atmosphere. The effect of the heat treatment on the hardness, fracture toughness, wear resistance, corrosion resistance, phase composition and microstructure behaviour of the coatings was investigated. It could be concluded from the X-ray diffraction (XRD) pattern that the phase of the coatings was mainly composed of tungsten carbide, an amorphous phase, a small amount of W2C and trace metal tungsten. However, the heat-treated coating had a small increase in W2C compared to the original coating, although the amount of amorphous phase did not decrease significantly. The results indicated that as the heat-treatment temperature increased, the hardness of the coating first increased and then decreased, while the fracture toughness increased. The polarization test confirmed that the heat-treated coating had higher corrosion resistance than the original coating. In addition, the results of the reciprocating friction and wear test indicated that small amounts of W2C strengthening phases were formed in the WC-10Co4Cr coating after heat treatment at 400 °C. This process did not eliminate many of the tougher Co and WC phases. Therefore, this coating had the best wear resistance among all the comparative coatings.
EXPLICIT TRANSFORMATION OF THE RICCATI EQUATION AND OTHER POLYNOMIAL ODES TO SYSTEMS OF LINEAR ODES
Authors: Zaytsev M.L. , Akkerman V.B. ,   West Virginia University (Morgantown, USA)
Published: December 2021

The purpose of this work is to propose and demonstrate a way to explicitly transform polynomial ODE systems to linear ODE systems. With the help of an additional first integral, the one-dimensional Riccati equation is transformed to a linear system of three ODEs with variable coefficients. Solving the system, we can find a solution to the original Riccati equation in the general form or only to the Cauchy problem. The Riccati equation is one of the most interesting nonlinear first order differential equations. It is proved that there is no general solution of the Riccati equation in the form of quadratures; however, if at least one particular solution is known, then its general solution is also found. Thus, it is enough only to find a particular solution of the linear system of ODEs. The applied transformation method is a special case of the method described in our work [Zaytsev M. L., Akkerman V. B. (2020) On the identification of solutions to Riccati equation and the other polynomial systems of ODEs // preprint, Research Gate. DOI: 10.13140 / RG.2.2.26980.60807]. This method uses algebraic transformations and transition to new unknowns consisting of products of the original unknowns. The number of new unknowns becomes less than the number of equations. For the multidimensional Riccati equations, we do not present the corresponding linear system of ODEs because of the large number of linear equations obtained (more than 100). However, we present the first integral with which this can be done. In this paper, we also propose a method for finding the first integral, which can be used to reduce a search for the solution of any polynomial systems of ODEs to a search of solutions to linear systems of ODEs. In particular, if the coefficients in these equations are constant, then the solution is found explicitly.
APPROXIMATE DETERMINATION OF GEOMETRIC PARAMETERS OF THE SAG FOLLOWING THE EMBEDDING OF A PARABOLOID INDENTER INTO A HALF-SPACE
Authors:   IMASH RAS (Moscow, Russian Federation), Albagachiev Ali Yu. , Moiseenko A.M. ,   Orel Branch of VEPI, Zernov E.V. ,   RTU-MIREA (Moscow, Russian Federation), Lut’yanov A.V. ,   RTU-MIREA (Moscow, Russian Federation)
Published: December 2021

The problem of the indenter embedding into a half-space is formulated and solved. A concept of the elastic contact is used, which implies the uniformity of the stress-strain state in a surface layer. The process of the surface layer formation after mechanical treatment is studied. Based on the general theory of indenter penetration into a half-space, numerical and analytical solutions, determining the length and depth of penetration of a paraboloid into elastoplastic space, are obtained. According to the theory of indentation, the problem is reduced to the use of the method of approximate determination of geometric parameters of a bead, when a paraboloid is being embedded into elastoplastic space. An exact solution to the formulated problem allows one to obtain analytical dependences for calculating the velocities and to study the stress-strain state of the material in the half-space surface layer during the processing. The reliability of the obtained analytical solution is confirmed by numerical calculations without introducing additional hypotheses. Based on the analytical solution, the geometric parameters of the influx from the penetration depth are determined. Calculations can be performed at any embedding depth. Sag formation during the indenter embedding by 18 mm into plasticine specimens is considered as an example. It is shown that the rigid zone is insignificant or absent.
SIMULATION OF AN UNSTEADY INCOMPRESSIBLE FLUID FLOW THROUGH A PERFORATED PIPELINE
Authors:   Azerbaijan State Oil and Industry University (Baku, Azerbaijan), Gamzaev Kh.M.
Published: December 2021

A mathematical model of the unsteady flow of an incompressible viscous fluid through a perforated pipeline is proposed, which is described by a system of nonlinear partial differential equations. In the framework of the model, the purpose is to determine the pressure and the flow rate of the fluid at the pipeline inlet, providing the flow rate and the pressure required at the pipeline outlet. By combining the system of the equations, the original problem is reduced to a boundary-value inverse problem for a nonlinear parabolic equation with respect to fluid flow rate. To solve the boundary inverse problem, the method of nonlocal perturbation of boundary conditions is proposed. A discrete analog of the inverse problem is obtained using the finitedifference approximation, and a special approach is suggested for solving the resulting system of difference equations. As a result, the difference problem for each discrete value of the time variable splits into two second-order difference problems and a linear equation with respect to an approximate value of the desired flow rate at the pipeline inlet. The absolutely stable Thomas method is used to numerically solve the obtained difference problems. After determining the flow rate distribution along the entire pipeline, the pressure at the pipeline inlet is also calculated using an explicit formula. Based on the proposed computational algorithm, the numerical experiments are performed for benchmark problems.
A New Axiological Bilingual Phraseological Dictionary by L. K. Bayramova. Book Review: Bayramova, L.K. (2019) Aksiologik Tatarcha-Ruscha Frazeologiya Suzlege/Aksiologicheskiy Tatarsko-Russkiy Frazeologicheskiy Slovar’ [Axiological Tatar-Russian Phraseological Dictionary]. Kazan: FEN
Authors:   International Ala-Too University (Bishkek, Kyrgyz Republic), Alimpieva Larisa V.
Published: December 2021

The Axiological Tatar-Russian Phraseological Dictionary contains 2,354 Tatar phraseological units with their Russian translations. The Tatar phraseological units (PU) reflect the following conventional values and anti-values: life (146 PU) – death (140 PU); health (70 PU) – disease (171); happiness (106 PU) – unhappiness (211 PU); homeland (95 FU) – foreign land (31 FU); labor (104 PU) – rest (7 PU) – idleness (49 PU); wealth (279 PU) – poverty (181 PU); intelligence (61 PU) – stupidity (73 PU); truth (128 PU) – lie (326); laughter (PU 52) – cry (PU 85); paradise (16 PU) – hell (24 PU). The dictionary reveals the etymology of the phraseological units, provides links to their bibliographic sources. The dictionary is intended for philologists and a wide range of readers.
Bioetički aspekti suvremene znanosti
Authors:   , Perušić Luka
Published: December 2021

Bioethical aspects of contemporary science. The dissertation presents the results of several years of research on the moral dimension of the system of contemporary science. The dissertation was divided into four main research sections – an introductory section devoted to methodology, and three sections on primary research and content, presented in detail in successive subsections following the problem area of the research sections. The dissertation aimed to explain the system of contemporary science, the elements of its being and the historical context in which the system perpetuates itself, identify and understand possible principles according to which it operates, explain the operational consequences manifested by its moral dimension of agency, and consider the alternative principle by which to orient the scientific enterprise.
A new Hexastylis (Aristolochiaceae) with uncertain origin in the southeastern U.S.A., discovered through social media
Authors: Keener Brian R. , Todia Gena
Published: December 2021

A new species of Hexastylis—H. rollinsiae—is herein described from cultivated material with uncertain origin. The discovery was facilitated through social media.
Natural history of neotropical Ericaceae, 1
Authors: Luteyn James L. , Díaz-Rueda Daniel Mauricio
Published: December 2021

Gonocalyx pulcher (Ericaceae: Vaccinieae) has been rediscovered in the northeastern Colombian Andes after a lapse of over 135 years. Recent collections herein reported represent the only collections made since the type gathering by Schlim in 1851. The history of collections, cultivation, taxonomy, and nomenclature is re-viewed. Generic and species descriptions for G. pulcher are updated and photographic illustrations are provided. The vegetation in which G. pulcher occurs, a list of its commonly associated Ericaceae, and its conservation status are briefly described. A new second-step lectotypification is made and the associated type herbarium specimens are illustrated. A key to all 11 species of Gonocalyx is provided.
Potent Max - Iskustva, Sastav, Cijena, Gdje Kupiti, Forum v1
Authors: not provided leicirligram
Published: December 2021

Potent Max
The Democratic Legitimacy of Secession and the Demos Problem
Authors: Martí José L.
Published: December 2021

The normative literature on secession has widely addressed the question of under which conditions the secession of a particular territory from a larger state might be regarded as justifiable. The idea of a normative justification of secession, however, remains ambiguous unless one distinguishes between the justice of secession and its legitimacy, a distinction that is now widely accepted in political philosophy. Much of the literature seems to have focused on the question about justice, while, in comparison, very little attention has been paid to the question of under which conditions secession can be regarded as democratically legitimate, as something explicitly different to the question of justice. This article addresses this second question. After some preliminary remarks, the article focuses on the main obstacle to develop a theory of democratic legitimacy of secessions, the so-called “demos problem.” Such problem, it is argued, has no categorical solution. This does not imply, however, that there is no democratic, legitimate way of redrawing our borders. Two strategies are proposed in this article to overcome the difficulty posed by the demos problem: an ideal strategy of consensus building and a non-ideal strategy of decision-making in the circumstances of disagreement.
Explaining Secessionism: What Do We Really Know About It?
Authors: Requejo Ferran , Sanjaume-Calvet Marc
Published: December 2021

In this thematic issue we discuss what we really know about the explanations for secessionism. Over the last few decades, an increasing number of new analyses on secessionism have appeared, regarding both its normative and its empirical dimensions. We can distinguish at least three types of research questions that categorise the current analyses of secessionism: normative, explanatory, and pragmatic. Political theorists work mainly on the moral and political right to unilaterally secede, answering questions such as “under what conditions” this right is legitimate and “who” has this moral right (Requejo & Sanjaume-Calvet, 2015; Sanjaume‐Calvet, 2020). Despite the importance of normative theories, these approaches do not provide explanations for secessionism, although most of them are built on implicit explanations of these phenomena. The field of explanatory theories of secession focuses mainly on the individual and/or aggregate preconditions and variables that correlate (or not) with the presence (or absence) of secessionist movements in specific territories. Through our general guiding question—”what do we really know about the explanations for secessionism?”—we try to disentangle the current explanations of secessionism by using empirical analyses, combining comparative politics and case studies. We bring together several different analytical perspectives, from political economy, nationalism, electoral behaviour, and institutional studies. Beyond these empirical perspectives, the issue puts forward some normative implications based on what we know and what we do not know about the existence of secessionist claims.
Analysis of relapse-free and overall survival in oncoplastic and organ-preserving surgeries in patients with breast cancer
Authors: Babayeva O. G. , Sidorov S. V. , Novikov S. S. , Kvon T. E. , Shevchenko K. E.
Published: December 2021

Purpose of the study. To study the results of relapse-free and overall survival during organ- preserving and oncoplastic surgeries in patients with breast cancer.

Materials and methods. A prospective clinical study of 84 patients was carried out in the mammology department on the basis of GBUZ NSO "GKB № 1". The first group of patients (40 patients) underwent OPR with ALAE - oncoplastic resection of the mammary gland with axillary lymphadenectomy. The second group (44 patients) WSR with ALAE - wide sector resection of the mammary gland with axillary lymphadenectomy.

During the study, the patients were comparable in age, stage (TNM), histological type, and morphogenetic data. The survival rate was studied by the number of local relapses and distant metastases, using laboratory and instrumental studies. The quality of life was assessed on the basis of anamnestic data (Karnofsky index, ECOG scale).

Results. In the first group of patients, disease-free and overall survival rate was 97.5 %. At the same time, a local recurrence was found in a patient with a triple negative tumor type, distant metastases to the lungs in a patient with a HER2/neu-positive type. In the second group, relapse-free survival was 95.4 %, overall - 97.7 %. Relapses in two patients with HER2/neu-positive type, metastases to the lungs in a patient with triple negative type.

Conclusion. Relapse-free survival rates are 2.1 % higher in group I patients who underwent oncoplastic resection with axillary lymphadenectomy. And the indicators of overall survival in patients of both groups do not differ relatively.
A rare case of solitary fibrous tumor of the liver and highly differentiated rectal adenocarcinoma
Authors: Shinkarev S. A. , Lando M. N. , Brykin V. N. , Zhinkin R. V. , Pestryakov O. E. , Odegov D. A.
Published: December 2021

Solitary fibrous tumors (SFT) are rare spindle cell mesenchymal neoplasms of presumably fibroblastic origin with undefined malignancy potential and rare metastasis. Their most frequent localization is in the pleura, where they have been first described. The incidence of solitary fibrous tumors localized in liver is extremely low. The clinical picture of SFT is nonspecific and is not due to the anatomical location of the tumor and it's size.

In the majority of cases these tumors are benign. However, a number of them still may have signs of malignancy: an aggressive course with possible local recurrence and distant metastasis. The main method of treatment of hepatic solitary fibrous tumor (as well as SFT of other localization) with it's resectability is surgery. Radical removal of the tumor in the majority of cases leads to recovery. Subsequently, the operated patients should be subjected to strict dynamic observation with regularity as in malignant neoplasms (MN).

The importance for chemotherapy and radiation therapy in the treatment of hepatic solitary fibrous tumor has not been determined in clinical guidelines to date.

There are isolated reports of the use of chemotherapy or radiation therapy for the treatment of cases when tumor resection is not radical or there are signs of malignant neoplasm.

In literature, there are numerous reports of a combination of a solitary fibrous tumor of any localization with malignant neoplasms of other organs in the same patients.

In this report, we represent a clinical case of a 64-year-old woman, who had a solitary fibrous tumor of the liver and highly differentiated rectal adenocarcinoma. The patient underwent resection of the first segment of the left lobe of the liver. After a month and a half, transanal excision of the villous tumor of the rectum. The pathologic and immunohistochemical examination of the liver tumor revealed a malignant solitary fibrous tumor. After researching villous tumor of the rectum - a highly differentiated adenocarcinoma with a depth of invasion of the submucous layer of the intestinal wall up to 1/3 (T1sm1 according to Kikuchi). During dynamic observation for twenty-five months after the operation, the patient has no signs of tumor recurrence and metastasis.
ON THE ISSUE OF JUDICIAL CONTROL OVER THE DISCRETION OF THE AUTHORITY
Authors:   National School of Judges of Ukraine, Onishchuk Mykola
Published: December 2021

Purpose. The purpose of the article is to define the concept of “discretionary powers”, to formulate conclusions on the limits of discretionary powers of government authorities, to analyze the limits of judicial control over discretionary powers, the correlation between court procedural discretion and public administration discretion. Methods. The theoretical and methodological basis of the study are modern general scientific and special legal methods of scientific knowledge. The formal-logical method and the method of analysis and synthesis are used in the study of doctrinal provisions on the concept of “discretionary powers”. The method of comparative legal analysis is used in the study of foreign models of judicial control over the exercise of discretionary powers. Results. The article defines the concept of “discretionary powers”, considers the types of administrative discretion, approaches to the scope of judicial control over the implementation of discretionary powers in different European countries, givthe criteria for effective judicial control over the exercise of discretionary powers. Conclusions. The attribute of effective judicial protection against illegal activity in the exercise of discretionary powers is the issuance of a court decision that makes it impossible to re-apply to the administrative body or re-resolve the same issue. Based on this, it is concluded that in Ukraine it is appropriate to apply the model of full judicial control, and the recognition of the disputed decision as illegal with the obligation to re-adopt the administrative decision is contrary to the rule of law principle, except the situations when: – there was no real consideration of the issue as such (non-compliance with the decision-making procedure, decision-making by an inappropriate subject); – there is an exclusive competence of the relevant body to make a specific decision (assign a rank, military rank, etc.).
OPPORTUNITY OF RATIONAL LEGISLATOR IN PRACTICE: LITHUANIA
Authors:   University of Mykolas Romeris, Beinoravičius Darijus
Published: December 2021

The legislator, officials of the state apparatus and the lawyers – all those who face creation, application, and systematization of legal acts – are especially interested in the perfection of such technique. Thinking in legislation is the key element in a process in which the legislator – both legal (lawyer) and political – has to choose one of the many solutions that consolidate social compromise. Legislative technique in Lithuanian doctrine is interpreted in a narrow and a broad sense. This article proves the necessity for the purview of laws to be determined by needs of the society and not by the will of authorities; it also explains how the legislator should apply legal sociology for this purpose. Scientific methods of legal sociology in lawmaking have been introduced relatively recently. The impact of law on political authorities in the process of lawmaking is reflected in actual legally consolidated politics. As legal awareness – „the spirit of law“ – has a direct impact on political processes and determines establishment of procedures, therefore politics itself becomes a part of law. Herewith in political processes the law becomes dynamic and politics itself becomes entrenched in law. In this article interpreting the legislative technique in a broad sense, as a set of methods and means used in preparation, publication and systematization of legal acts, one of its goals should be distinguished – to improve the legislative process from a technical point of view. In Lithuania, it needs to be noted that the content of these requirements have undergone positive changes in quality with the changes of legal acts. In addition to general technical – linguistical requirements material content requirements have been set forth, constituting the scope of individual regulation, the relationship with other legal acts, the essential principles of public relations regulated, etc. At the same time, references to the source of official publication were abandoned, and all these changes lead to conclusion, that the legislative technique in this area has become simpler and clearer and it contributes to the development of better lawmaking.
THE ADMINISTRATIVE CONTRACT IN SERBIAN LAW
Authors:   University of Belgrade, Marković Ivana
Published: December 2021

The paper deals with the new legal institute of administrative contract in Serbian Administrative Law. It was introduced in 2016 in the Law on General Administrative Procedure (LGAP), establishing rules on its definition, modification and termination, objection due to non-performance and subsidiary application of law on obligations. The prevailing opinions from the Serbian legal theory are shown through the analysis of the relevant articles of the LGAP with regard to the administrative contract – its definition, modification and termination of administrative. It is to be underlined that the problematic issues concern the differing legal positions of the public body and the private entity as contracting parties, as well as the consequence of this – a disputed legal nature of the administrative contract. It is concluded that the administrative contract in Serbian Law has a particular legal regulation; that it cannot be equated to a pure administrative act, nor a civil contract. Its normative regime is characterized by an ambivalent legal nature, where two legally unequal wills come to an agreement on the establishment of a mutual commitment (obligation), but with effects for the public as well. Here, the public side of the contract has a stronger standing and can to a greater extent influence the content of the contract. Baring in mind the positive (flexibility, efficiency, direct fulfillment of contractual aims with less governmental compulsion) and the negative effects (possible corruption, “selling out” of sovereign rights, endangerment of the uniformity of the legal system) of this instrument, it can be anticipated that the fragmented character of the regulations of the LGAP on the administrative contract will induce judicial practice and legal theory to give answers that the legislator omitted to provide.
INVERSE PROBLEMS OF SOIL BIOKINETICS
Authors: Glagolev Mikhail Vladimirovich
Published: December 2021

This work represents the materials of the report prepared at the suggestion of N. S. Panikov in 19851986, when the author was a third-year student at the Faculty of Soil Science, M.V. Lomonosov Moscow State University.
The report contains definitions of direct and inverse problems. A classification of inverse problems and several examples of such problems encountered in soil science and biological kinetics are given. The question of the ill-posed inverse problems is touched, and the main methods of their solution are briefly listed. The problem of identifying a gas source in a soil column by the layer-by-layer balance method (based on measurements of the dynamics of the concentration field) is considered in detail. This task is shown as a computer program, and for others, useful links to programs published in the literature are given.
Effects of High-quality Nursing Plus Elastic Band Resistance Exercise on Pulmonary Functions and Quality of Life in Elderly Patients with Chronic Obstructive Pulmonary Disease
Authors: Zhang Lingling , Yuan Xia
Published: December 2021

This paper was aimed at exploring the effects of high-quality nursing (HQN) plus elastic band resistance exercise (EBRE) on pulmonary functions and quality of life (QOL) in elderly patients with chronic obstructive pulmonary disease (COPD). Altogether 97 patients with COPD, who came
to our hospital for treatment and rehabilitation training from December 2016 to March 2019, were selected and divided into a control group (n=46) and a test group (n=51). Those in the control group were given EBRE plus routine nursing, whereas those in test group were given EBRE plus HQN.
The indices of their pulmonary and cardiac functions were assessed. Their negative emotions were assessed and compared between the two groups through the Self-rating Depression Scale (SDS) and the Self-rating Anxiety Scale (SAS). Finally, their adverse reactions, QOL and nursing satisfaction
were also assessed and compared. After nursing, the pulmonary functions, the cardiac functions, the negative emotions and the QOL were remarkably improved in both groups, but the improvement of these indicators was more obvious in the test group (P<0.05). Compared with the control group,
patients in the test group had a remarkably lower incidence of adverse reactions (P<0.05), but remarkably higher nursing satisfaction (P<0.05). or elderly patients with COPD, HQN plus EBRE can improve the rehabilitation effects on them, and improve their pulmonary functions and QOL,
so this combination is worthy of clinical promotion.
Influence of Human-oriented Nursing Mode on Self-Care Ability, Unhealthy Emotion and Quality of Life of Patients with Benign Prostatic Hyperplasia
Authors: Peng Feifei , Xu Guangchi , Zhu Caihong , Sun Lanchun , Dong Bo , Meng Yin , Liu Songtao , Zhang Xinxin , Liu Tao
Published: December 2021

To explore the influence of human-oriented nursing mode on the self-care ability, unhealthy emotion and quality of life of patients with benign prostatic hyperplasia (BPH), 147 patients with BPH admitted to our hospital from February 2018 to August 2019 were selected and all patients
were separated into two groups on the basis of the nursing intervention mode. 77 cases in the research group (RG) were given the human-oriented nursing mode and 70 cases in the control group (CG) were given the conventional nursing mode. The bladder irrigation time (BIT), indwelling catheter
time (ICT), postoperative hospitalization time (PHT) and the incidence rate of postoperative complications were observed in the two groups after nursing intervention. Before and after nursing intervention, the self-care ability of patients was evaluated in the two groups by Exercise of Self-Care
Agency Scale (ESCA). In the two groups, the anxiety and depression status were evaluated by the Self-rating Anxiety Scale (SAS) and the Self-rating Depression Scale (SDS). The Quality of Life Scale for Benign Prostatic Hyperplasia Patient (BPHQLS) was applied to evaluate the quality of life
in both groups before and after nursing intervention. The International Prostate Symptom Score (IPSS) was used to assess the lower urinary tract symptoms (LUTS) of patients in the two groups before and after nursing intervention. The self-made nursing satisfaction questionnaire was used to
evaluate the nursing satisfaction in the two groups. The BIT, ICT and PHT in RG after nursing intervention were obviously lower than those in CG, and the incidence of postoperative complications in RG was also obviously lower than that in CG (p < 0.05). The ESCA score of patients in RG
after nursing intervention was significantly higher than that in CG (P < 0.05). The SAS and SDS scores of patients in RG after nursing intervention were significantly lower than those in CG (P < 0.05). The BPHQLS score in RG after nursing intervention was obviously higher than that in
CG (P < 0.05). The IPSS score of patients in RG after nursing intervention was obviously lower than that in CG (p < 0.05). The nursing satisfaction score in RG after nursing intervention was obviously higher than that in CG (p < 0.05).Condusion: The application effect of the human-oriented
nursing mode on patients with BPH is definite, which can improve self-care ability, unhealthy emotion and effectively ameliorate the quality of life.
Application of Standardized Nursing Procedures Combined with Specialized Management Education in Extracorporeal Membrane Oxygenation in ICU
Authors: Zhang Min , Wu Lingling , Shen Weihong , Shen Ying
Published: December 2021

To analyze the application effect of standardized nursing procedures combined with specialized management education in extracorporeal membrane oxygenation (ECMO) in ICU. 18 patients treated with ECMO in our department from July 1, 2020 to December 30, 2020 were chosen as observation
group, and 18 patients receiving ECMO in our department (January 2017-June 2018) were selected as control group. The control group received routine procedures in the implementation of ECMO nursing while the observation group received standardized ECMO nursing procedures combined with specialized
management education to analyze the effect of different nursing management methods on ECMO patients by comparing the indexes before and after nursing management. There were no obvious differences in gender ratio, average age, average weight, average BMI, marital status, education and residence
between the two groups (P > 0.05). Personnel arrival time, start time of rescue, preparation time of items, pipeline prefilling time and catheter completion time in observation group were obviously better compared with control group (P < 0.001). The total clinical efficacy rate in observation
group was obviously higher compared with control group (P < 0.05). There were no significant differences in the Pa02, SP02 and PaC02 levels between the two groups before nursing management (P > 0.05), and the levels in observation group were obviously higher compared with control group
after nursing management (P < 0.001). The clinical nursing satisfaction in observation group was obviously higher compared with control group (P < 0.05). The sequential organ failure assessment (SOFA) score in observation group after nursing management was obviously lower compared with
control group (P < 0.001). The incidence of complications in observation group was obviously lower compared with control group (P < 0.05). The implementation of standardized nursing procedures combined with specialized management education for ECMO patients can effectively shorten rescue
time, the preparation time before catheterization and catheter completion time, improve the therapeutic effect, and improve blood gas indicators, safe and effective. At the same time, it can facilitate the doctor-nurse cooperation, worthy of promotion and application.
Clinical efficacy of cefoperazone-sulbactam in patients with acute myocardial infarction complicated with infection and effects on serum procalcitonin and serum inflammatory indicators Running tittle: Cefoperazone-sulbactam in acute myocardial infarction complicated with infection
Authors: Wang Shan , Zhao Xiaohua , Sun Wenbao
Published: December 2021

This study aimed to investigate clinical efficacy of cefoperazone-sulbactam in patients with acute myocardial infarction complicated by infection and effects on serum procalcitonin and serum inflammatory indicators. Prospective analysis was used in this study. A total of 109 cases
of patients with acute myocardial infarction complicated with infection were collected. They were admitted to our hospital from August 2018 to September 2019 and were divided into a control group and an experimental group according to different treatment methods. Patients (53 cases) in the
control group received treatment of cefoperazone, while patients (56 cases) in the experimental group received treatment of cefoperazone-sulbactam. Therapeutic effect, bacterial clearance rate and adverse reaction of the two groups were compared. Serum procalcitonin (PCT) and serum hypersensitive
C-reactive protein (hs-CRP) levels were observed and compared. ROC curve was used to analyze the predictive value of PCT, hs-CRP for the treatment of acute myocardial infarction complicated by infection. Logistic regression analysis was used to analyze the risk factors for the effect of acute
myocardial infarction complicated by infection. The effective rates and bacterial clearance rates of treatment in the experimental group were higher than those in the control group (P<0.05). After treatment, the PCT and hs-CRP levels of the experimental group were lower than those of the
control group (P<0.05). Age, hypertension, length of hospital stay, heart failure and hs-CRP were independent risk factors affecting the effective rate of treatment for acute myocardial infarction complicated by infection. In conclusion, cefoperazone-sulbactam has good therapeutic effect
on acute myocardial infarction complicated with infection. It can reduce the level of PCT and serum inflammatory indicator hs-CRP; PCT and hs-CRP have certain predictive value on the therapeutic effect, which is worthy of promotion.
Improved cardiovascular risk stratification with PET: [18F]meta-fluorobenzylguanidine as a potential cardiac radiotracer
Authors: Meyer Austin , Snyder Scott
Published: December 2021

Background and Hypothesis: 
Cardiovascular disease is the leading cause of death in the United States each year, exceeding 600,000 deaths and costing over $200B. Sympathetic dysfunction in cardiac tissue has been shown to occur in patients with recent cardiac injury or longstanding disease. The SPECT radiotracer, meta-[123I]iodobenzylguanidine (MIBG), has been used to image neuroendocrine tumors as well as global cardiac sympathetic tone through the human norepinephrine transporter-1. We will determine the utility and improved imaging the PET radiotracer meta-[18F]fluorobenzylguanidine (MFBG) can afford in cardiac care. MFBG has shown several improvements over MIBG in neuroendocrine tumors but has proven difficult to reliably synthesize. 
Project Methods: 
A novel synthetic pathway of MFBG utilizing copper accelerated Sandmeyer fluorination conditions is being developed to streamline its radiosynthesis from seven manipulations and an unstable precursor to four with more stable intermediates.  
We also explored where MFBG may be useful in cardiology by performing a literature review through the PubMed MeSH database published after 2010. 
Results: 
We have developed a new MFBG precursor in one step from commercially available compounds and a one-pot automated radiosynthesis is currently in development. This improves upon current methods and may provide increased clinical availability of MFBG for future studies. 
MIBG has shown prognostic value for the incidence of severe cardiac events but cannot provide any local innervation data. The PET radiotracer, [11C]hydroxyephedrine, can display local denervation within the myocardium. However, its 20.3 minute half-life prevents its widespread use beyond hospitals with direct access to a radiochemistry laboratory. To our knowledge, no cardiac imaging has been investigated using MFBG. 
Conclusion and Potential Impact: 
We believe MFBG could provide similar improvements to cardiac imaging as in neuroendocrine tumors. With a novel synthetic method being developed, we hope to begin pre-clinical imaging studies and provide future cardiologists with a new prognostic imaging modality which can direct personalized care to patients with cardiovascular disease.
Evaluating the effects of RAS and CK2 Inhibitors in ESR1 Mutated Breast Cancer
Authors: Suescum Camilo , Nakshatri Harikrishna
Published: December 2021

Background and Hypothesis:
Estrogen Receptor alpha (ESR1) is rarely mutated in primary breast cancers but is frequently mutated in metastasis that can appear after many years of anti-estrogen therapy. Mutations to ESR1 can result in estrogen-independent activity of ESR1 causing anti-estrogen to become ineffective. Previous work on this project has led to the hypothesis that RAS pathway activation in metastatic cancer cells as a result of ESR1 mutation leads to elevated CK2 activity which ultimately results in metastatic progression. Therefore, we hypothesize that the use of RAS signaling inhibitors or CK2 inhibitors have efficacy in blocking or reducing the metastatic progression of metastatic breast cancers with hyperactive RAS pathways.
Experimental Design or Project Methods:
The estrogen receptor positive, anti-estrogen sensitive breast cancer cell line MCF-7 and the same cell line genomically modified to replace wild type ESR1 to breast cancer metastasis enriched Y537S or D538G ESR1 mutation were used in this study. Cells were treated with various concentrations of the RAS pathway inhibitor Salirasib or CK2 inhibitor Silmitasertib and cell proliferation rates were measured using bromodeoxyuridine incorporation ELISA.
Results:
Thus far, the use of RAS signaling inhibitors or CK2 inhibitors have not shown efficacy in decreasing the proliferation rates of modified ESR1 MCF-7 cells. While there is a general trend of growth inhibition by these inhibitors at a higher concentration, there is no significant difference between the ESR1 mutant expressing cells and their respective controls. 
Conclusion and Potential Impact:
This study will establish the feasibility of using RAS signaling inhibitors or CK2 inhibitors in the treatment of metastatic estrogen receptor-positive breast cancer. Future studies testing the effects of these drugs either alone or in combination with the clinically used anti-estrogen Fulvestrant for not only primary tumor growth but also metastasis in clinically relevant in vivo models may ultimately lead to clinical translation.  Finally, demonstrating efficacy in these types of drugs may fuel the further refinement of drugs targeting these pathways to treat metastatic breast cancer.
Metabolic Syndrome and SIRT1 Mutation Impair Ca2+ Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine
Authors: Thamba Aish , Reed John , Strobel John S. , Byrd James , Alloosh Mouhamad , Coutts Alex , Sturek Michael
Published: December 2021

Background:
Changes in Ca2+ regulation have been implicated in various pathologies such as coronary artery disease and metabolic syndrome (MetS), thereby potentiating these diseases. Our lab has shown that MetS decreases voltage-gated Ca2+ channel (VGCC) activity and sarcoplasmic reticulum (SR) Ca2+ release in coronary smooth muscle cells and increases coronary artery disease in Ossabaw miniature swine. Furthermore, decreased SIRT1 enzyme function can impair Ca2+ signaling and increase coronary disease and MetS. We hypothesized that impaired SIRT1 and MetS would decrease VGCC function and SR calcium store.
Methods:
CRISPR/Cas9 methods delivered a leucine to proline point mutation in SIRT1 (SIRT1L100P) into the Ossabaw swine genome to compare to wild type (WT), mimicking the naturally occurring mutation in humans which decreases SIRT1 activity. Four treatment groups of juvenile swine were based on genotype and diet: WT Lean, SIRT1 Lean, WT MetS, and SIRT1 MetS. Lean swine were fed normal chow and MetS were fed a hypercaloric, atherogenic diet for 7 months. The left anterior descending coronary artery was harvested and enzymatically digested to obtain cells. Fluorescence microscopy measured the Ca2+ indicator fura-2 in single cells. Depolarization of cells with perfusion of 80 mM K+ was used to elicit Ca2+ influx through VGCC.  Caffeine (5 mM) exposure activated the Ca2+ release channel (ryanodine receptor) on the SR.
Results:
MetS was confirmed by increased body weight, impaired glucose tolerance, hyperinsulinemia, and hypercholesterolemia. Coronary atherosclerosis was shown by angiography, intravascular ultrasound, and gross imaging. A two-way analysis of variance revealed statistically significant overall effects of genotype (p=0.02), diet (p<0.0001), and an interaction (p<0.0001) between these variables to decrease VGCC function. In contrast, no effect was observed on SR Ca2+ release.
Conclusion and Potential Impact:
SIRT1 inhibition and MetS decreased VGCC function independently, but not additively or synergistically. (Support: NIH T35HL110854, DK120240, DK09751.)
Using Lyve1-Cre+ Mice to Visualize Lymphatics for Laser Capture Microdissection
Authors: Patel Aadarsh , Mohan Ganesh , Khan Imran , Sinha Mithun , Hassanein Aladdin H.
Published: December 2021

Background: 
Lymphedema is characterized by limb swelling secondary to lymphatic dysfunction. Lymphedema most frequently develops following breast cancer treatment due to iatrogenic damage of the lymphatics from surgery and radiation. Lymphedema affects 20-40% of breast cancer survivors. There is no cure for this disease. For determination of successful delivery of gene-based therapies, target cells are often isolated and analyzed via real-time PCR. One method to isolate a region of cells within a tissue section is laser capture microdissection (LCM). This process involves outlining the desired regions, which are cut on membrane slides and captured using a laser. Using LCM requires visualization and identification of the target tissue. In the case of lymphedema therapies, the target tissue is lymphatic vasculature.  
 
Rationale of Project:  
While lymphatics can be visualized using immunohistochemistry antibodies specific to lymphatic markers, the process is time consuming and can interfere with RNA levels in the tissue. Another option to visualize lymphatics is to use Lyve1-Cre+ mice. These mice express enhanced green fluorescent protein on lymphatic cells. The purpose of this project is to assess the utility of Lyve1-Cre+ and develop the methodology to capture the lymphatics in the murine tail to enable utilization of this methodology in murine tail model of lymphedema. 
 
Methodology Development: 
Samples of Lyve1-Cre+ mouse tails were harvested. Sections (10µm) were captured on LCM slides and dehydrated. The slides were visualized on the LCM microscope system, lymphatics vessels fluoresced green. They were captured via laser dissection. The captured samples were analyzed for the lymphatic specific genes (Prox1 and Lyve1) via quantitative real-time PCR to determine the purity of capture.
The Impact of Primary Language on Knowledge of Labor Induction and Birth Satisfaction Prior to Implementation of Standardized Video Education
Authors: Crowe Sierra , Pape Kelsey , Haas David M.
Published: December 2021

Background and Hypothesis: Induction of labor (IOL) is common, with as many as 1 in 4 labors being induced in the U.S. There is a lack of standardized patient education surrounding induction, however, which may contribute to patients’ expectations, feeling a lack of control, and lower birth satisfaction. We hypothesize that implementation of a video education tool prior to patients’ arrival for IOL may help manage patient expectations and improve birth satisfaction. Our objective was to ascertain knowledge, expectations, and satisfaction with IOL in a group of women before implementation of standardized pre-procedure education.
Methods: Patients scheduled for induction were given a questionnaire after their delivery. The survey included knowledge and expectation questions about their induction, as well as the validated Birth Satisfaction Scale Revised (BSS-R). Birth and induction medication information were extracted from the medical record. Descriptive statistics were compiled, and knowledge and satisfaction scores were explored between English and Spanish surveys.
Results: Our group consisted of 32 women, 19 English speaking and 13 Spanish speaking. The average BSS-R score was 26.87 ± 4.76. The average subcategory scores for stress experienced, personal attributes, and quality of care were 8.26 ± 3.15, 4.00 ± 2.03, and 14.81 ± 1.69, respectively. 65.7% of subjects correctly identified whether they received misoprostol during their induction. Correct identification for cervical ripening balloon (CRB), artificial rupture of membranes (AROM), and Pitocin use was 87.5%, 53.1%, and 56.3% respectively. There were few differences between English and Spanish speakers.
Conclusions: While BSS-R scores for quality of care were high, overall stress experienced and personal attributes relating to anxiety could be improved. Additionally, just over half of the women correctly identified agents used in their induction. We anticipate that after standardized video education before induction, we will have improved knowledge, expectations, and satisfaction for women undergoing IOL.