bluuebunny/crossref_metadata_2025 huggingface dataset:
What If Pregnancy Is Not Seventh Heaven? The Influence of Specific Life Events during Pregnancy and Delivery on the Transition of Antenatal into Postpartum Anxiety and Depression
Authors: Aris-Meijer Judith , Bockting Claudi , Stolk Ronald , Verbeek Tjitte , Beijers Chantal , van Pampus Mariëlle , Burger Huibert
Published: August 2019

Introduction: Postpartum symptoms of anxiety and depression are known to have a negative impact on mother and child, and major life events constitute a major risk factor for these symptoms. We aimed to investigate to what extent specific life events during pregnancy, delivery complications, unfavorable obstetric outcomes, and antenatal levels of anxiety or depression symptoms were independently associated with postpartum levels of anxiety and depression symptoms. Methods: Within a prospective population-based cohort study (n = 3842) in The Netherlands, antenatal symptoms of anxiety or depression were measured at the end of the first trimester and at five months postpartum. Antenatal life events were assessed during the third trimester, and information on delivery and obstetric outcomes was obtained from midwives and gynecologists. Linear regression analyses were performed to quantify the associations. Results: Antenatal levels of both anxiety and depression symptoms were associated with postpartum levels of anxiety and depression symptoms. Life events related to health and sickness of self or loved ones, to the relation with the partner or conflicts with loved ones, or to work, finance, or housing problems were significantly associated with higher postpartum levels of anxiety symptoms (p < 0.001) and depression symptoms (p < 0.001) adjusted for antenatal levels. No statistically significant results were observed for pregnancy-related events, delivery complications, or unfavorable obstetric outcomes. Conclusions: Women with increased antenatal levels of anxiety or depression symptoms are at increased risk of elevated levels of both postpartum depression and anxiety symptoms. Experiencing life events during pregnancy that were not related to the pregnancy was associated with higher levels of anxiety and depression in the postpartum period, as opposed to pregnancy-related events, delivery complications, or unfavorable obstetric outcomes. These results suggest that events during pregnancy but not related to the pregnancy and birth are a highly important predictor for postpartum mental health.
Validation of the CIMI-Ethiopia Program and Seasonal Variation in Maternal Nutrient Intake in Enset (False Banana) Growing Areas of Southern Ethiopia
Authors: Bosha Tafese , Lambert Christine , Riedel Simon , Gola Ute , Melesse Aberra , Biesalski Hans K.
Published: August 2019

Background: Tools for the rapid and accurate analysis of nutrient intakes from diets of individuals in Southern Ethiopia are lacking. The Calculator of Inadequate Micronutrient Intake program for Ethiopia (CIMI-Ethiopia) has been developed to overcome this problem. CIMI-Ethiopia also computes protein and energy intakes from the diet. The objectives of the current study were to validate CIMI-Ethiopia for the dietary pattern of Southern Ethiopia, and assess the nutrient intakes in postharvest dry and lean wet seasons. Methods: 24-h dietary recall (24HR) data was collected from 578 women of a reproductive age in postharvest dry and lean wet seasons in 2017. For analysis, 24HR data was entered into NutriSurvey (NS), which was the reference nutrition software, and then into CIMI-Ethiopia. For validation, the mean and standard deviation (SD) of the difference between CIMI-Ethiopia and NS were computed. The percentage of participants with an inadequate intake was calculated. The correlation between CIMI-Ethiopia and NS results was determined. The nutrient intakes in postharvest dry and lean seasons were compared. Results: Among the nutrients, pantothenic acid, vitamin B1, and protein showed a very high accuracy in CIMI-Ethiopia calculation (|difference (D)| < 5.0% of the NS result). Nutrients with a good accuracy (|D| = 5%–15%) were iron, zinc, magnesium, vitamin B12, vitamin B6, and energy. The accuracy for calcium, niacin, and vitamin A was moderate (|D| = 15%–30%). The intakes calculated by CIMI-Ethiopia and NS of iron, zinc, magnesium, calcium, B-complex vitamins, vitamin A, protein, and energy were highly correlated (r = 0.85–0.97, p < 0.001). NS analysis identified a significant reduction in the mean intake of iron; zinc; magnesium; pantothenic acid; vitamin B1, B12, and D; protein; and energy in the lean wet season; however, calcium and vitamin A intake increased. Conclusions: It has been found that CIMI-Ethiopia is a valid tool for estimating nutrient intakes at an individual level in Southern Ethiopia. The study demonstrated a decline in intakes of iron; zinc; magnesium; pantothenic acid; vitamin B1, B12, and D; protein; and energy in the lean wet season. This result provides some hint for fortification and supplementation programs that aim to combat maternal malnutrition in rural Southern Ethiopia.
Chernobyl’s Lesser Known Design Flaw: The Chernobyl Liquidator Medal—An Educational Essay
Authors: McIntire Michael , Luczaj John
Published: August 2019

The honorary Chernobyl Liquidator Medal depicts pathways of alpha, gamma, and beta rays over a drop of blood, signifying the human health impacts of the Chernobyl accident. A relativistic analysis of the trajectories depicted on the Chernobyl Liquidator Medal is conducted assuming static uniform magnetic and electric fields. The parametric trajectories are determined using the energies of alpha (α) and beta (β) particles relevant to the Chernobyl nuclear power plant accident and compared with the trajectories depicted on the liquidator medal. For minimum alpha particle velocity of 0.0512c, the beta particle trajectory depicted on the medal is highly unlikely to have come from a naturally occurring nuclear decay process. The parametric equations are used to determine the necessary beta energies to reproduce the depicted trajectories. This article documents the unfortunate misrepresentation of a famous scientific experiment on an honorary medal and illustrates the importance of better communication between artists and scientists.
Measurement of Adhesion of Sternal Wires to a Novel Bioactive Glass-Based Adhesive
Authors: Sidhu Varinder Pal Singh , Towler Mark R. , Papini Marcello
Published: August 2019

Stainless steel wires are the standard method for sternal closure because of their strength and rigidity, the simplicity of the process, and the short healing time that results from their application. Despite this, problems still exist with sternal stability due to micromotion between the two halves of the dissected and wired sternum. Recently, a novel glass-based adhesive was developed which, in cadaveric trials and in conjunction with wiring, was shown to restrict this micromotion. However, in order to avoid complications during resternotomy, the adhesive should adhere only to the bone and not the sternal wire. In this study, sternal wires were embedded in 8 mm discs manufactured from the novel glass-based adhesive and the constructs were then incubated at 37 °C for one, seven, and 30 days. The discs were manufactured in two different thicknesses: 2 and 3 mm. Wire pull-out tests were then performed on the constructs at three different strain rates (1, 0.1, and 0.01 mm/min). No statistically significant difference in pull-out force was found regardless of incubation time, loading rate, or construct thickness. The pull-out forces recorded were consistent with static friction between the wire and adhesive, rather than the adhesion between them. Scanning electron micrographs provided further proof of this. These results indicate that the novel adhesive may be suitable for sternal fixation without complicating a potential resternotomy.
Associations between Perceptual Fatigue and Accuracy of Estimated Repetitions to Failure during Resistance Exercises
Authors: Hackett Daniel A. , Selvanayagam Victor S. , Halaki Mark , Cobley Stephen P.
Published: August 2019

The ability to accurately identify proximity to momentary failure during a set of resistance exercise might be important to maximise training adaptations. This study examined the association between perceptual fatigue and the accuracy of the estimated repetitions to failure (ERF). Twenty-seven males and eleven females performed sets of 10 repetitions at specific loads for the chest press and leg-press. Following the completion of 10 repetitions, participants rated their fatigue and ERF and then proceeded to concentric failure (actual repetitions to failure) to determine the ERF accuracy (i.e., error-ERF). Small correlations were found between perceptual fatigue and error-ERF for the chest-press (r = −0.26, p = 0.001) and the leg-press (r = −0.18, p = 0.013). For actual repetitions to failure and error-ERF, a strong correlation was found for the chest-press (r = 0.68, p < 0.001) and a very strong correlation was foundfor the leg-press (r = 0.73, p < 0.001). Moderate correlations were found between perceptual fatigue and actual repetitions to failure for the chest-press (r = −0.42, p < 0.001) and leg-press (r = −0.40, p < 0.001). Overall, findings suggest that the accuracy of the estimated repetitions to failure is more strongly associated with proximity to task repetition failure rather than subjective feelings of fatigue.
3D Forging Simulation of a Multi-Partitioned Titanium Alloy Billet for a Medical Implant
Authors: Turner Richard , Antonic Jeff , Warnken Nils
Published: August 2019

The medical healthcare industry uses titanium and its alloys to manufacture structural implants such as hip and knee replacement joints, which require an interface with bone, as well biocompatibility with soft tissue. These components can be manufactured with a variety of processing routes; however, forging has been one of the traditionally used, successful methods. In order to enhance a medical implant component’s properties such as fracture toughness, strength, microstructure and biocompatibility, it is of interest to understand a capability to develop forging methods which can produce a finished component such that different initial partitions of the billet occupy specific locations. As such, a 3D finite element (FE) modelling framework was established to simulate the coupled thermal and mechanical processes experienced during the forging of a workpiece containing multiple titanium-alloy material partitions, using the commercial FE software, Deform. A series of four models were simulated which contained differing arrangements of partitioning the initial billet, with different titanium alloys assigned to partitions. The forging operation was simulated with the same nominal processing parameters. The locations of these partitions within the final forging have been predicted, with varying success. One partition combination gave a very unsuccessful filling of the die, whilst the other models all filled the die correctly, and had different partitions maintained at key component locations. Thus, allowing for a manufacturing methodology to be presented which can potentially target specific component locations for specific materials to enhance component performance.
Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV
Authors: Caceres Diego , Valdes Audrey
Published: August 2019

Distinguishing between histoplasmosis, tuberculosis (TB), and co-occurrence of disease is a frequent dilemma for clinical staff treating people with advanced Human Immunodeficiency Virus (HIV) infection. This problem is most frequently observed in clinical settings in countries where both diseases are endemic. It is also a challenge outside these endemic countries in HIV clinics that take care of patients coming from countries with endemic histoplasmosis and TB. The gold standard for diagnosis of both of these diseases is based on conventional laboratory tests (culture, histopathology and special stains). These tests have several limitations, such as lack of laboratory infrastructure for handling isolates (biosafety level 3), shortage of laboratory staff who have appropriate training and experience, variable analytical performance of tests and long turn-around time. Recently, novel rapid assays for the diagnosis of histoplasmosis and TB became available. However, this technology is not yet widely used. Mortality in immunocompromised patients, such as people with advanced HIV, is directly linked with the ability to rapidly diagnose opportunistic diseases. The aim of this review is to synthesize the main aspects of epidemiology, clinical characteristics, diagnosis and treatment of histoplasmosis/TB co-occurrence in people with advanced HIV.
The Influence of Surface Texturing on the Frictional Behaviour in Starved Lubricated Parallel Sliding Contacts
Authors: Bijani Dariush , Deladi Elena L. , de Rooij Matthijn B. , Schipper Dirk J.
Published: August 2019

Starvation occurs when the lubricated contact uses up the lubricant supply, and there is not enough lubricant in the contact to support the separation between solid surfaces. On the other hand, the use of textures on surfaces in lubricated contacts can result in a higher film thickness. In addition, a modification of the surface’s geometrical parameters can benefit the tribological behaviour of the contacts. In this article, for parallel sliding surfaces in starved lubricated conditions, the effect of surface texturing upon the coefficient of friction is investigated. It is shown that surface texturing may improve film formation under the conditions of starvation, and as a result, the frictional behaviour of the parallel sliding contact. Furthermore, the effect of starved lubrication on textured surfaces with different patterns in the presence of a cavitation effect, and its influence on frictional behaviour, is investigated. It is shown that surface texturing can reduce the coefficient of friction, and that under certain conditions, the texturing parameter could have an influence on the frictional behaviour of parallel sliding contacts in the starved lubrication regime.
Health Benefits of Indoor Cycling: A Systematic Review
Authors: Chavarrias Manuel , Carlos-Vivas Jorge , Collado-Mateo Daniel , Pérez-Gómez Jorge
Published: August 2019

Background and Objectives: Indoor cycling is one of the most practiced activities in fitness centers for most people regardless of their physical conditioning level. Several studies have analyzed the effect of indoor cycling on several parameters related to health, such as maximal oxygen consumption, blood pressure, body composition, as well as biochemical markers such as HDL or LDL. However, no study has synthesized all health benefits associated with the indoor cycling practice in the form of a systematic review and established guidelines or recommendations. Therefore, the aim of this manuscript was to conduct a systematic review of published studies about the benefits of indoor cycling training and to establish recommendations for coaches, researchers, and practitioners. Materials and Methods: The PRISMA guidelines were followed to conduct the current systematic review. A systematic search was performed to retrieve relevant published articles until January 2019 using the following keywords: ‘indoor cycling’, ‘indoor bicycle’, and ‘spinning exercise’. Information about participants, intervention, comparisons, outcomes, and study design (PICOS) was extracted. Results: A total of 300 studies were initially identified. After the revision process, 13 of them were included. The total sample size of the studies was 372 (306 women). Results revealed that indoor cycling may improve aerobic capacity, blood pressure, lipid profile, and body composition. These enhancements may be achieved as standalone intervention or combined with other physical exercises or diet. Conclusions: The combination of indoor cycling and diet is recommended to improve the lipid profile, lose weight, and reduce blood pressure. Furthermore, indoor cycling alone may also enhance aerobic capacity. Given the lack of randomized controlled trials, these conclusions should be taken with caution.
What Does the Chinese Public Care About with Regard to Primary Care Physicians: Trustworthiness or Competence?
Authors: Zhu Egui , Cao Yang
Published: August 2019

Background and Objective: China has launched a series of reforms to enhance primary care. The aims of these reforms are to strengthen the functionality of primary care to encourage patients to use primary care. Patients’ trust in physicians is important in clinical medicine; however, little is known about how Chinese patients’ preferences relate to their trust in primary care physicians. This study’s objectives are to measure the Chinese public’s trust in primary care physicians and to characterize reasons of their preferences for health care. Materials and Methods: This quantitative study comprises a face-to-face survey with a convenience sample (n = 273) of people visiting community health centers or stations (CHCSs) in Wuhan, China. We measured the patients’ preferences for the different level of hospitals and their trust in physicians, as well as the reasons of the patients’ preferences, using a Chinese version of the Wake Forest Physician Trust Scale and other variables (such as demographics, health status, and hospital preference). Results: Approximately two thirds (68.6%) of the participants had experienced a mild or chronic disease in the year before the survey, but only 26.4% preferred to visit CHCSs in such cases. The negative factors related to this lack of preference are the physicians’ competence (odds ratio [OR] = 0.250), the medical equipment (OR = 0.301), and the popularity of hospitals (OR = 0.172). The positive factors were ease of access (OR = 2.218) and affordability (OR = 1.900). The participants expressed a moderate trust in physicians in CHCSs (score of 3.02 out of 5). There is no association between the patients’ trust and their hospital preference (r = 0.019, p = 0.859). Of the participants, 92 suggested that the physicians in CHCSs should improve in terms of their competence (n = 53), attitude (n = 35), and/or medical ethics (n = 16). Conclusions: This study’s results suggest that patients consider improving physicians’ competence to be more important and urgent than improving those physicians’ trustworthiness in terms of reconstructing Chinese primary care. Improving the physicians’ competence would not only reduce the barriers that patients experience regarding CHCSs, but would also increase their trust in the physicians.
Epicardial Adipose Tissue Accumulation and Essential Hypertension in Non-Obese Adults
Authors: Austys Donatas , Dobrovolskij Andrej , Jablonskienė Valerija , Dobrovolskij Valerij , Valevičienė Nomeda , Stukas Rimantas
Published: August 2019

Background and Objectives: Epicardial adipose tissue (EAT) is shown to be an important factor in the development of coronary artery disease, but numerous pathophysiological mechanisms of its action are still only partially understood. There is a lack of studies on its association with different grades of essential hypertension (EH). Therefore, we aimed to evaluate the association between size of EAT depots and the risk of EH taking into account its grade. Materials and Methods: Non-obese adult patients with various cardiovascular diseases were investigated: 157 of them had essential hypertension and 101 did not. Hypertensive patients were assigned to three groups according to the grade of hypertension. EAT volume and thickness on ventricular free walls (6 locations) and grooves (5 locations) were measured using cardiac magnetic resonance imaging and compared between groups. A regression model for the prediction of EH was constructed. Results: In general, thickness (in all locations) and volume of EAT depots was greater among hypertensive patients than in normotensive (NORM) group. Mean EAT thickness in all 11 locations and EAT volume were lower in NORM than in grade 1 hypertension group; similarly, EAT volume was lower in grade 1 than in grade 2 hypertension group. EAT accumulation did not differ between grade 2 and severe hypertension groups. EAT volume, dyslipidaemia status, body mass index, and age were independent predictors for EH in regression model. Conclusions: EAT accumulation is larger among hypertensive than normotensive individuals. Measurement of EAT depots could be beneficial for identification of hypertensive patients and prediction of hypertension severity.
Risk Factors for Emergency Department Unscheduled Return Visits
Authors: Soh Crystal Harn Wei , Lin Ziwei , Pan Darius Shaw Teng , Ho Weng Hoe , Mahadevan Malcolm , Chua Mui Teng , Kuan Win Sen
Published: August 2019

Background and Objectives: This study aims to identify reasons for unscheduled return visits (URVs), and risk factors for diagnostic errors leading to URVs, with comparisons to data from a similar study conducted in the same institution 9 years ago. Materials and Methods: This retrospective study included adult patients who attended the emergency department (ED) of a tertiary hospital in Singapore between January 2014 and June 2014, with re-attendance within 72 h for the same or similar complaint. The primary outcome was wrong or delayed diagnoses. Secondary outcomes include admission to the ED observation unit or ward on return visit. Findings were compared with the previous study performed in 2005 to identify trends. Results: Of 67,422 attendances, there were 1298 (1.93%) URVs from 1207 patients (median age 34, interquartile range 24 to 52 years; 59.7% male). The most common presenting complaint was abdominal pain (22.2%). One hundred ninety-one (15.8%) patients received an initial wrong or delayed diagnosis. Factors (adjusted odds ratio; 95% CI) associated with this were: presenting complaints of abdominal pain (2.99; 2.12–4.23), fever (1.60; 1.1–2.33), neurological deficit (4.26; 1.94–9.35), and discharge without follow-up (1.61; 1.1–2.26). Among re-attendances, 459 (38.0%) required admission. Factors (adjusted odds ratio; 95% CI) associated with admission were: male gender (1.88; 1.42 to 2.48); comorbidities of diabetes mellitus (2.07; 1.29–3.31), asthma (5.23; 1.59–17.26), and renal disease (7.48; 2.00–28.05); presenting complaints of abdominal pain (1.83; 1.32–2.55), fever (3.05; 2.10–4.44), and giddiness or vertigo (2.17; 1.26–3.73). There was a reduction in URV rate compared to the previous study in 2005 (1.93% versus 2.19%). Abdominal pain at the index visit remains a significant cause of URVs (22.2% versus 25.1%). Conclusions: Presenting complaints of neurological deficits, abdominal pain, fever, and discharge without follow-up were associated with wrong or delayed diagnoses among URVs.
Analysis of the Vertical Driving Performance of Multiple Connected Pipe-Climbing Microrobots with Magnetic Wheels
Authors: Takeda Munehisa , Shimoyama Isao
Published: August 2019

In this study, we analyzed the vertical driving performance of multiple connected magnetic wheel-driven microrobots when moving up and down a small cylinder that simulated a pipe. The dynamics of pipe climbing by the magnetic wheel-driven microrobot were analyzed considering the magnetic attraction force and slip; a vertical climbing simulator was developed considering the hoop force and external force from the adjacent microrobots to determine the magnetic attraction force required for multiple connected microrobot pipe climbing. A prototype of an independent vertical climbing microrobot, 5 mm long, 9 mm wide, and 6.5 mm high, and prototypes of 10 microrobots were manufactured to evaluate the vertical driving performance. The usefulness was verified by showing that three driving microrobots can move seven non-driving microrobots comprising 60% of their own weight up and down along a small cylinder.
Microscale Surface Tension and its Applications
Authors: Lambert Pierre , Mastrangeli Massimo
Published: August 2019

More than 200 years since the earliest scientific investigations by Young, Laplace and Plateau, liquid surface tension is still the object of thriving fundamental and applied research [...]
Enzymatic Reactions in a Lab-on-Valve System: Cholesterol Evaluations
Authors: S. Barbosa Jucineide , L.C. Passos Marieta , A. Korn M. das Graças , M.F.S. Saraiva M. Lúcia
Published: August 2019

The micro sequential injection analysis / lab-on-valve (µSIA-LOV) system is a miniaturized SIA system resulting from the implementation of a lab-on-valve (LOV) atop of the selection valve. It integrates the detection cell and the sample processing channels into the same device, promoting the reduction of reagent consumption and waste generation, the improvement of the versatility, and the reduction of the time of analysis. All of these characteristics are really relevant to the implementation of enzymatic reactions. Additionally, the evaluation of cholesterol in serum samples is widely relevant in clinical diagnosis, since higher values of cholesterol in human blood are actually an important risk factor for cardiovascular problems. An automatic methodology was developed based on the µSIA-LOV system in order to evaluate its advantages in the implementation of enzymatic reactions performed by cholesterol esterase, cholesterol oxidase and peroxidase. Considering these reactions, the developed methodology was also used for the evaluation of cholesterol in human serum samples, showing reliable and accurate results. The developed methodology presented detection and quantification limits of 1.36 and 4.53 mg dL−1 and a linear range up to 40 mg dL−1. This work confirmed that this µSIA-LOV system is a simple, rapid, versatile, and robust analytical tool for the automatic implementation of enzymatic reactions performed by cholesterol esterase, cholesterol oxidase, and peroxidase. It is also a useful alternative methodology for the routine determinations of cholesterol in real samples, even when compared with other automatic methodologies.
Insight into the PTP1B Inhibitory Activity of Arylbenzofurans: An In Vitro and In Silico Study
Authors: Shrestha Srijan , Seong Su Hui , Park Seul Gi , Min Byung Sun , Jung Hyun Ah , Choi Jae Sue
Published: August 2019

Protein tyrosine phosphatase 1B (PTP1B) plays a specific role as a negative regulator of insulin signaling pathways and is a validated therapeutic target for Type 2 diabetes. Previously, arylbenzofurans were reported to have inhibitory activity against PTP1B. However, detailed investigation regarding their structure activity relationship (SAR) has not been elucidated. The main aim of this work was to investigate the PTP1B inhibitory activity of 2-arylbenzofuran analogs (sanggenofuran A (SA), mulberrofuran D2 (MD2), mulberrofuran D (MD), morusalfuran B (MB), mulberrofuran H (MH)) isolated from the root bark of Morus alba. All compounds demonstrated potent inhibitory activity with IC50 values ranging from 3.11 to 53.47 µM. Among the tested compounds, MD2 showed the strongest activity (IC50, 3.11 µM), followed by MD and MB, while SA and MH demonstrated the lowest activity. Lineweaver-Burk and Dixon plots were used for the determination of inhibition type whereas ligand and receptor interactions were investigated in modeled complexes via molecular docking. Our study clearly supports 2-arylbenzofuran analogs as a promising class of PTP1B inhibitors and illustrates the key positions responsible for the inhibitory activity, their correlation, the effect of prenyl/geranyl groups, and the influence of resorcinol scaffold, which can be further explored in-depth to develop therapeutic agents against T2DM.
Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities
Authors: Wrońska Natalia , Majoral Jean Pierre , Appelhans Dietmar , Bryszewska Maria , Lisowska Katarzyna
Published: August 2019

Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.
Cooked Red Lentils Dose-Dependently Modulate the Colonic Microenvironment in Healthy C57Bl/6 Male Mice
Authors: Graf Daniela , Monk Jennifer M. , Lepp Dion , Wu Wenqing , McGillis Laurel , Roberton Kyle , Brummer Yolanda , Tosh Susan M. , Power Krista A.
Published: August 2019

Dietary pulses, including lentils, are protein-rich plant foods that are enriched in intestinal health-promoting bioactives, such as non-digestible carbohydrates and phenolic compounds. The aim of this study was to investigate the effect of diets supplemented with cooked red lentils on the colonic microenvironment (microbiota composition and activity and epithelial barrier integrity and function). C57Bl/6 male mice were fed one of five diets: a control basal diet (BD), a BD-supplemented diet with 5, 10 or 20% cooked red lentils (by weight), or a BD-supplemented diet with 0.7% pectin (equivalent soluble fiber level as found in the 20% lentil diet). Red lentil supplementation resulted in increased: (1) fecal microbiota α-diversity; (2) abundance of short-chain fatty acid (SCFA)-producing bacteria (e.g., Prevotella, Roseburia and Dorea spp.); (3) concentrations of fecal SCFAs; (4) mRNA expression of SCFA receptors (G-protein-coupled receptors (GPR 41 and 43) and tight/adherens junction proteins (Zona Occulden-1 (ZO-1), Claudin-2, E-cadherin). Overall, 20% lentil had the greatest impact on colon health outcomes, which were in part explained by a change in the soluble and insoluble fiber profile of the diet. These results support recent public health recommendations to increase consumption of plant-based protein foods for improved health, in particular intestinal health.
Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children
Authors: Hattangdi-Haridas Sonal R , Lanham-New Susan A , Wong Wilfred Hing Sang , Ho Marco Hok Kung , Darling Andrea L
Published: August 2019

Research has investigated 25-hydroxyvitamin D (25(OH)D) levels in the Atopic Dermatitis (AD) population, as well as changes in AD severity after vitamin D (VitD) supplementation. We performed an up-to-date systematic review and meta-analysis of these findings. Electronic searches of MEDLINE, EMBASE and COCHRANE up to February 2018 were performed. Observational studies comparing 25(OH)D between AD patients and controls, as well as trials documenting baseline serum 25(OH)D levels and clinical severity by either SCORAD/EASI scores, were included. Of the 1085 articles retrieved, sixteen were included. A meta-analysis of eleven studies of AD patients vs. healthy controls (HC) found a mean difference of −14 nmol/L (95% CI −25 to −2) for all studies and −16 nmol/L (95% CI −31 to −1) for the paediatric studies alone. A meta-analysis of three VitD supplementation trials found lower SCORAD by −11 points (95% CI −13 to −9, p < 0.00001). This surpasses the Minimal Clinical Important Difference for AD of 9.0 points (by 22%). There were greater improvements in trials lasting three months and the mean weighted dose of all trials was 1500–1600 IU/daily. Overall, the AD population, especially the paediatric subset, may be at high-risk for lower serum 25(OH)D. Supplementation with around 1600 IU/daily results in a clinically meaningful AD severity reduction.
Clinical Care Pharmacists in Urgent Care in North East England: A Qualitative Study of Experiences after Implementation
Authors: Nichols Jody , England Rosie , Holliday Stuart , Newton Julia L
Published: August 2019

Our objective was to explore the implementation of a novel NHS England (NHSE)-funded pilot project aimed at deploying clinical pharmacists in an integrated urgent care (IUC) setting including the NHS 111 service. Eight integrated urgent care clinical pharmacists (IUCCPs) within the participating North East of England Trusts. Individuals participated in semi-structured 1-to-1 interviews by an experienced qualitative researcher, either face-to-face or via the telephone. Each recording was transcribed, and the five stages of framework analysis (familiarisation, identifying a thematic framework, indexing, charting, mapping and interpretation) took place to establish emerging themes. All interviews took place between November 2018–February 2019. Four higher-order themes were identified: 1. Personality Traits, 2. Integration, 3. Benefits, 4. Training. The IUCCP programme is an innovative NHSE initiative. It provides an opportunity to extend the role of clinical pharmacists into the hard-pressed clinical environment of urgent and emergency care. Our evaluation has highlighted the potential for this professional group to contribute clinically in this area. Better communications, standard operating procedures and induction will improve how individuals develop in these novel roles.
(PVA/Chitosan/Fucoidan)-Ampicillin: A Bioartificial Polymeric Material with Combined Properties in Cell Regeneration and Potential Antibacterial Features
Authors: Bernal-Ballen Andres , Lopez-Garcia Jorge-Andres , Ozaltin Kadir
Published: August 2019

Chitosan, fucoidan, and polyvinyl alcohol are categorized as polymers with biomedical applications. Ampicillin, on the other hand, is considered as an important antibiotic that has shown effectivity in both gram-positive and gram-negative micro-organisms. The aforementioned polymers possess unique properties that are considered desirable for cell regeneration although they exhibit drawbacks that can affect their final application. Therefore, films of these biomaterials were prepared and they were characterized using FTIR, SEM, XRD, degree of swelling and solubility, and MTT assay. The statistical significance of the experiments was determined using a two-way analysis of variance (ANOVA) with p < 0.05. The characterization techniques demonstrated that the obtained material exhibits properties suitable for cell regeneration, and that a higher concentration of natural polymers promotes cells proliferation to a greater extent. The presence of PVA, on the other hand, is responsible for matrix stability and dictates the degree of swelling and solubility. The SEM images demonstrated that neither aggregations nor clusters were formed, which is favorable for the biological properties without detrimental to the morphological and physical features. Cell viability was comparatively similar in samples with and without antibiotic, and the physical and biological properties were not negatively affected. Indeed, the inherent bactericidal effect of chitosan was reinforced by the presence of ampicillin. The new material is an outstanding candidate for cell regeneration as a consequence of the synergic effect that each component provides to the blend.
Production Planning to Reduce Production Cost and Formaldehyde Emission in Furniture Production Process Using Medium-Density Fiberboard
Authors: Kim Taeho
Published: August 2019

This research seeks to improve the production process in the Korean furniture industry by reducing the amount of medium-density fibreboard, that is commonly used to produce furniture, in order to reduce production costs and formaldehyde emissions. This research selects a representative company from the Korean furniture industry to examine its optimal amount of medium-density fibreboard used, using the variables of a previous company; the sale levels, the Korea National Productivity Award Index, and technical efficiencies obtained from a previous study. By using its 2016 production level, we compare it with the amount of medium-density fibreboards actually used in 2016, and apply the results to the entire Korean furniture industry. In conclusion, the Korean furniture industry can minimize the amount of medium-density fibreboards used without reducing current production levels, and thereby save production costs, and contribute to substantially reducing formaldehyde emissions.
A Real-Time On-Orbit Signal Tracking Algorithm for GNSS Surface Observations
Authors: Gleason Scott
Published: August 2019

This manuscript describes real-time on-orbit instrument compatible open loop signal tracking techniques for Global Navigation Satellite Systems (GNSS) reflection observations. All GNSS-reflection (GNSS-R) satellite instruments require algorithms which run in real-time on-board the satellite, that are capable of predicting the code phase time delay and Doppler frequency of surface reflected signals. The algorithms presented here are for open loop tracking techniques in reflected GNSS signals for the purposed of making surface remote sensing observations. Initially, the algorithms are demonstrated using high resolution sampled data from the NASA Cyclone GNSS (CYGNSS) mission over ocean and land surfaces. Subsequently. the algorithm performance over ocean regions is analyzed in detail using a larger data set. As part of the analysis, the algorithm is assessed for its speed of convergence, to demonstrate general compatibility with spacecraft instrument processing limitations. Results indicate that over ocean regions is it possible to robustly predict in real time the Doppler frequency and code phase time delay of multiple reflected signal to sufficient precision to make science observations of the scattering surface. These algorithms are intended to provide a baseline technique and variations from which the scientific community can design more specialized algorithms for individual applications.
Examination of Strenuous Activity Preceding Cardiac Death during Firefighting Duties
Authors: Haller Jeannie M. , Smith Denise L.
Published: August 2019

Sudden cardiac death accounts for approximately 45% of duty-related fatalities among United States firefighters. Strenuous physical exertion is recognized as a trigger of sudden cardiac events. This study describes the duration of strenuous physical exertion on-scene preceding a fatal cardiac event by situation encountered during firefighting duties. Data provided by the National Institute for Occupational Safety and Health Fire Fighter Fatality Investigation and Prevention Program for duty-related firefighter fatalities over a 9-year period were analyzed. Among the 235 fatalities investigated, 45% had a cause of death that was cardiac in origin. Time (mean ± SD) spent on-scene in strenuous work was 30 ± 26 min, 14 ± 15 min, and 47 ± 52 min for fire, non-fire emergency, and training situations, respectively. Across all emergency operations and training, 31% of fatalities occurred among firefighters who performed ≤10 min of strenuous work, whereas 13% of fatalities occurred among those who performed >60 min. Study findings indicate that there is considerable variability in the duration of strenuous work preceding fatal cardiac events during firefighting duties. Notably, a high percentage of fatal cardiac events occurred after a relatively brief period of strenuous work, suggesting that the performance of any strenuous work, even that of short duration, may be sufficient to provoke a cardiac event in a firefighter with underlying cardiac disease.
Legitimate Exclusion of Would-Be Immigrants: A View from Global Ethics and the Ethics of International Relations
Authors: Camacho-Beltrán Enrique
Published: August 2019

The debate about justice in immigration seems somehow stagnated given that it seems justice requires both further exclusion and more porous borders. In the face of this, I propose to take a step back and to realize that the general problem of borders—to determine what kind of borders liberal democracies ought to have—gives rise to two particular problems: first, to justify exclusive control over the administration of borders (the problem of legitimacy of borders) and, second, to specify how this control ought to be exercised (the problem of justice of borders). The literature has explored the second but ignored the first. Therefore, I propose a different approach to the ethics of immigration by focusing on concerns of legitimacy in a three-step framework: first, identifying the kind of authority or power that immigration controls exercise; second, redefining borders as international and domestic institutions that issue that kind of power; and finally, considering supranational institutions that redistribute the right to exclude among legitimate borders.
Evaluation of Chinese Enterprise Safety Production Resilience Based on a Combined Gray Relevancy and BP Neural Network Model
Authors: Pei Jingjing , Liu Wen
Published: August 2019

Improving the resilience of enterprise safety production is one of the important ways to deal with the frequency of safety accidents. Based on the definition of enterprise safety production resilience, we fully consider the impacts of recovery resilience, self-organizing resilience, and learning resilience as the three dimensions of enterprise safety production resilience. We build a back propagation (BP) neural network model that analyzes the main factors of enterprise safety production resilience using the results of gray relational analysis as an input that can assess the resilience of enterprise safety production and provide a valuable reference for the improvement of an enterprise’s safety production level. The results show that the resilience of production safety obviously increased after the Chinese enterprises with low resilience (as predicted by the model) adopted the corresponding early warning methods. The gray relational degree analysis method can incorporate well the variables for the establishment of the BP neural network prediction model.
Counting Oceanians of Non-European, Non-Asian Descent (ONENA) in the South Pacific to Make Them Count in Global Health
Authors: Tarantola Arnaud , Horwood Paul F. , Goarant Cyrille , Buffière Bertrand , Bertrand Solène , Merilles Onofre Edwin A. , Pedron Thierry , Klement-Frutos Elise , Sansonetti Philippe , Quintana-Murci Lluis , Richard Vincent
Published: August 2019

Several diseases and vulnerabilities associated with genetic or microbial factors are more frequent among populations of Oceanian, Non-European, Non-Asian descent (ONENA). ONENA are specific and have long been isolated geographically. To our knowledge, there are no published official, quantitative, aggregated data on the populations impacted by these excess vulnerabilities in Oceania. We searched official census reports for updated estimates of the total population for each of the Pacific Island Countries and Territories (including Australia) and the US State of Hawaii, privileging local official statistical or censual sources. We multiplied the most recent total population estimate by the cumulative percentage of the ONENA population as determined in official reports. Including Australia and the US State of Hawaii, Oceania counts 27 countries and territories, populated in 2016 by approximately 41 M inhabitants (17 M not counting Australia) among which approximately 12.5 M (11.6 M not counting Australia) consider themselves of entire or partial ONENA ancestry. Specific genetic and microbiome traits of ONENA may be unique and need further investigation to adjust risk estimates, risk prevention, diagnostic and therapeutic strategies, to the benefit of populations in the Pacific and beyond.
Evaluation of Temperature Profiling and Seepage Meter Methods for Quantifying Submarine Groundwater Discharge to Coastal Lagoons: Impacts of Saltwater Intrusion and the Associated Thermal Regime
Authors: Tirado-Conde Joel , Engesgaard Peter , Karan Sachin , Müller Sascha , Duque Carlos
Published: August 2019

Surface water-groundwater interactions were studied in a coastal lagoon performing 180 seepage meter measurements and using heat as a tracer in 30 locations along a lagoon inlet. The direct seepage meter measurements were compared with the results from analytical solutions for the 1D heat transport equation in three different scenarios: (1) Homogeneous bulk thermal conductivity (Ke); (2) horizontal heterogeneity in Ke; and (3) horizontal and vertical heterogeneity in Ke. The proportion of fresh groundwater and saline recirculated lagoon water collected from the seepage experiment was used to infer the location of the saline wedge and its effect on both the seepage meter results and the thermal regime in the lagoon bed, conditioning the use of the thermal methods. The different scenarios provided the basis for a better understanding of the underlying processes in a coastal groundwater-discharging area, a key factor to apply the best-suited method to characterize such processes. The thermal methods were more reliable in areas with high fresh groundwater discharge than in areas with high recirculation of saline lagoon water. The seepage meter experiments highlighted the importance of geochemical water sampling to estimate the origin of the exchanged water through the lagoon bed.
FUZZY EXTREME SYSTEM OF AUTOMATIC ADJUSTMENT OF A RESONANCE CIRCUIT
Authors: Пышьев Р. , Pyshev R. , Рубанов В. , Rubanov V.
Published: August 2019

In robotics, radio transmission can be used in communication systems that are an integral part of robots and serve to organize the exchange of information between the robot and humans or other robots in order to carry out a dialogue, formulate tasks for the robot, monitor the functioning of its systems, diagnose faults, routine checks, etc. The resonant circuit is used if it is necessary to prevent the passage of a signal of a certain frequency, passing other signals, for example, to remove the interference at a certain frequency or vice versa, to ground all signals except the desired frequency. The static characteristic of the circuit is a parabolic dependence with the presence of an extremum at the resonant frequency. In this case, by changing the parameters of the oscillating circuit or the frequency of the voltage applied to the circuit, one can observe the horizontal drift of the amplitude-frequency characteristic of the circuit. Adaptation to changes in static characteristics and their drift contributes to the construction of systems of extreme regulation. The main disadvantage of such systems is the presence of frequent actuators accompanying the search mode and the so-called “search” and “yaw” losses, which ultimately leads to a decrease in the efficiency of automatic tuning and reliability of devices for its implementation. One of the ways to reduce these negative properties is the development of extreme combined systems that use the properties of the static characteristics of the object of regulation. There is an increasing interest in improbable models of uncertainty and fuzziness, in particular, in the analysis and synthesis of fuzzy process control systems and regulators. The time and cost of designing fuzzy control systems, as shown by practical experience in developing such systems, is significantly lower than when using the traditional mathematical apparatus, and the organization of fuzzy control provides the required quality levels.