bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction
Authors: Hughes Francis M. , Odom Michael R. , Cervantes Anissa , Purves J.Todd
Published: November 2022

Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by 2050. This disease is characterized by devastating complications brought about high glucose and metabolic derangement. The most common of these complications is diabetic bladder dysfunction (DBD) and estimates suggest that 50–80% of patients experience this disorder. Unfortunately, the Epidemiology of Diabetes Interventions and Complications Study suggests that strict glucose control does not decrease ones risk for incontinence, although it does decrease the risk of other complications such as retinopathy, nephropathy and neuropathy. Thus, there is a significant unmet need to better understand DBD in order to develop targeted therapies to alleviate patient suffering. Recently, the research community has come to understand that diabetes produces a systemic state of low-level inflammation known as meta-inflammation and attention has focused on a role for the sterile inflammation-inducing structure known as the NLRP3 inflammasome. In this review, we will examine the evidence that NLRP3 plays a central role in inducing DBD and driving its progression towards an underactive phenotype.
Validation of a high-confidence regulatory network for gene-to-NUE phenotype in field-grown rice
Authors: Shanks Carly M. , Huang Ji , Cheng Chia-Yi , Shih Hung-Jui S. , Brooks Matthew D. , Alvarez José M. , Araus Viviana , Swift Joseph , Henry Amelia , Coruzzi Gloria M.
Published: November 2022

Nitrogen (N) and Water (W) - two resources critical for crop productivity – are becoming increasingly limited in soils globally. To address this issue, we aim to uncover the gene regulatory networks (GRNs) that regulate nitrogen use efficiency (NUE) - as a function of water availability - in Oryza sativa, a staple for 3.5 billion people. In this study, we infer and validate GRNs that correlate with rice NUE phenotypes affected by N-by-W availability in the field. We did this by exploiting RNA-seq and crop phenotype data from 19 rice varieties grown in a 2x2 N-by-W matrix in the field. First, to identify gene-to-NUE field phenotypes, we analyzed these datasets using weighted gene co-expression network analysis (WGCNA). This identified two network modules ("skyblue" & "grey60") highly correlated with NUE grain yield (NUEg). Next, we focused on 90 TFs contained in these two NUEg modules and predicted their genome-wide targets using the N-and/or-W response datasets using a random forest network inference approach (GENIE3). Next, to validate the GENIE3 TF→target gene predictions, we performed Precision/Recall Analysis (AUPR) using nine datasets for three TFs validatedin planta. This analysis sets a precision threshold of 0.31, used to "prune" the GENIE3 network for high-confidence TF→target gene edges, comprising 88 TFs and 5,716 N-and/or-W response genes. Next, we ranked these 88 TFs based on their significant influence on NUEg target genes responsive to N and/or W signaling. This resulted in a list of 18 prioritized TFs that regulate 551 NUEg target genes responsive to N and/or W signals. We validated the direct regulated targets of two of these candidate NUEg TFs in a plant cell-based TF assay called TARGET, for which we also hadin plantadata for comparison. Gene ontology analysis revealed that 6/18 NUEg TFs - OsbZIP23 (LOC_Os02g52780), Oshox22 (LOC_Os04g45810), LOB39 (LOC_Os03g41330), Oshox13 (LOC_Os03g08960), LOC_Os11g38870, and LOC_Os06g14670 - regulate genes annotated for N and/or W signaling. Our results show that OsbZIP23 and Oshox22, known regulators of drought tolerance, also coordinate W-responses with NUEg. This validated network can aid in developing/breeding rice with improved yield on marginal, low N-input, drought-prone soils.
Genetic diversity and structure of Bipolaris oryzae and Exserohilum rostratum populations causing brown spot of rice in Burkina Faso based on genotyping-by-sequencing
Authors: Kaboré Kouka Hilaire , Kassankogno Abalo Itolou , Adreit Henri , Milazzo Joëlle , Guillou Sonia , Blondin Laurence , Chopin Laurie , Ravel Sébastien , Charriat Florian , Barro Mariam , Tollenaere Charlottte , Lebrun Marc-Henri , Tharreau Didier
Published: November 2022

In recent years, Brown spot disease of rice (BSR) has been observed on leaves and seeds of rice in all rice-growing areas of Burkina Faso. Bipolaris oryzae and Exserohilum rostratum are the main fungal species isolated from BSR infected tissues and they are frequently observed in the same field. However, we are lacking information on the genetic diversity and population structure of these fungi in Burkina Faso. The mode of reproduction is also unknown. The genetic diversity of isolates of B. oryzae (n=61) and E. rostratum (n=151), collected from major rice-growing areas of Burkina Faso, was estimated using genotyping-by-sequencing (GBS). The mean values for nucleotide diversity (π) were 1.9 x10-4 for B. oryzae and 4.8 x10-4 for E. rostratum. There is no genetic differentiation between the geographical populations of each species. The analysis of molecular variance revealed that 89% and 94% of the genetic variances were within the populations of B. oryzae and E. rostratum, respectively. For each species, four genetic clusters were identified by two clustering methods (DAPC and sNMF). The distribution of these genetic groups was independent of the geographical origin of the isolates. Evidence of recombination was detected in the populations of B. oryzae and E. rostratum. For B. oryzae balanced mating type ratios were supporting sexual reproduction. For E. rostratum overrepresentation of MAT1-2 isolates (79%) suggested a predominant asexual reproduction. This study provides important information on the biology and genetics of the two major fungi causing brown spot disease of rice in Burkina Faso.
Monsoon intensification in East Asia triggered the evolution of its flora
Authors: Ye Jun-Wei , Tian Bin , Li De-Zhu
Published: November 2022

Introduction

East Asia (EA), which falls within the region of the Asian monsoon that is composed of the East Asia monsoon (EAM) and the Indian monsoon (IM), is known for its high species diversity and endemism. This has been attributed to extreme physiographical heterogeneity in conjunction with climate and sea-level changes during the Pleistocene, this hypothesis has been widely proven by phylogeographic studies. Recently, dated phylogenies have indicated that the origins (stem age) of the flora occurred after the Oligocene–Miocene boundary and are related to the establishment of the EAM.

Methods

Hence, this study further examined whether the strengthening of the monsoons triggered floral evolution via a meta-analysis of the tempo-spatial pattern of evolutionary radiation dates (crown ages) of 101 endemic seed plant genera.

Results

Taxonomic diversification began during the late Eocene, whereas the accumulated number of diversifications did not significantly accelerate until the late Miocene. The distribution of the weighted mean and the average divergence times in the EAM, IM, or transitional regions all fall within the mid-late Miocene. Fossils of the Tertiary relict genera are mostly and widely distributed outside EA and only half of the earliest fossils in the EA region are not older than Miocene, while their divergence times are mostly after the late Miocene. The pattern of divergence time of monotypic and polytypic taxa suggest the climatic changes after the late Pliocene exert more influence on monotypic taxa.

Discussion

The two key stages of floral evolution coincide with the intensifications of the EAM and IM, especially the summer monsoon which brings a humid climate. An integrated review of previous studies concerning flora, genus, and species levels further supports our suggestion that monsoon intensification in EA triggered the evolution of its flora.
Effects of chilling on the photosynthetic performance of the CAM orchid Phalaenopsis
Authors: Daems Stijn , Ceusters Nathalie , Valcke Roland , Ceusters Johan
Published: November 2022

Introduction

Crassulacean acid metabolism (CAM) is one of the three main metabolic adaptations for CO2 fixation found in plants. A striking feature for these plants is nocturnal carbon fixation and diurnal decarboxylation of malic acid to feed Rubisco with CO2 behind closed stomata, thereby saving considerable amounts of water. Compared to the effects of high temperatures, drought, and light, much less information is available about the effects of chilling temperatures on CAM plants. In addition a lot of CAM ornamentals are grown in heated greenhouses, urging for a deeper understanding about the physiological responses to chilling in order to increase sustainability in the horticultural sector.

Methods

The present study focuses on the impact of chilling temperatures (10°C) for 3 weeks on the photosynthetic performance of the obligate CAM orchid Phalaenopsis ‘Edessa’. Detailed assessments of the light reactions were performed by analyzing chlorophyll a fluorescence induction (OJIP) parameters and the carbon fixation reactions by measuring diel leaf gas exchange and diel metabolite patterns.

Results and Discussion

Results showed that chilling already affected the light reactions after 24h. Whilst the potential efficiency of photosystem II (PSII) (Fv/Fm) was not yet influenced, a massive decrease in the performance index (PIabs) was noticed. This decrease did not depict an overall downregulation of PSII related energy fluxes since energy absorption and dissipation remained uninfluenced whilst the trapped energy and reduction flux were upregulated. This might point to the presence of short-term adaptation mechanisms to chilling stress. However, in the longer term the electron transport chain from PSII to PSI was affected, impacting both ATP and NADPH provision. To avoid over-excitation and photodamage plants showed a massive increase in thermal dissipation. These considerations are also in line with carbon fixation data showing initial signs of cold adaptation by achieving comparable Rubisco activity compared to unstressed plants but increasing daytime stomatal opening in order to capture a higher proportion of CO2 during daytime. However, in accordance with the light reactions data, Rubisco activity declined and stomatal conductance and CO2 uptake diminished to near zero levels after 3 weeks, indicating that plants were not successful in cold acclimation on the longer term.
Integrating artificial intelligence into a talent management model to increase the work engagement and performance of enterprises
Authors: Rožman Maja , Oreški Dijana , Tominc Polona
Published: November 2022

The purpose of the paper is to create a multidimensional talent management model with embedded aspects of artificial intelligence in the human resource processes to increase employees' engagement and performance of the enterprise. The research was implemented on a sample of 317 managers/owners in Slovenian enterprises. Multidimensional constructs of the model include several aspects of artificial intelligence implementation in the organization's activities related to human resource management in the field of talent management, especially in the process of acquiring and retaining talented employees, appropriate training and development of employees, organizational culture, leadership, and reducing the workload of employees, employee engagement and performance of the enterprise. The results show that AI supported acquiring and retaining a talented employees, AI supported appropriate training and development of employees, appropriate teams, AI supported organizational culture, AI supported leadership, reducing the workload of employees with AI have a positive effect on performance of the enterprise and employee engagement. The results will help managers or owners create a successful work environment by implementing artificial intelligence in the enterprise, leading to increased employee engagement and performance of the enterprise. Namely, our results contribute to the efficient implementation of artificial intelligence into an enterprise and give owners or top managers a broad insight into the various aspects that must be taken into account in business management in order to increase employee engagement and enterprise’s competitive advantage.
The influence of social constraints on the quality of life of hematopoietic stem cell transplantation survivors: The chain mediating effect of illness perceptions and the fear of cancer recurrence
Authors: Shen Zhiying , Shi Shuangjiao , Li Chengyuan , Ruan Chunhong
Published: November 2022

Objective

This cross-sectional correlational study aims to explore the relationship between social constraints and the quality of life of hematopoietic stem cell transplantation (HCT) survivors. Additionally, we also seek to demonstrate the chain mediating effect of illness perceptions and the fear of cancer recurrence on this relationship.

Methods

Convenience sampling was employed in this study. A total of 232 HCT survivors were interviewed using the Social Constraints Scale, the Brief Illness Perception Questionnaire, the Fear of Cancer Recurrence Inventory (Short Form) and the Functional Assessment of Cancer Therapy–Bone Marrow Transplant. IBM SPSS 24.0 were used for data analyses, and PROCESS macro (Model 6) was used to examine the hypothesized chain mediation model.

Results

A positive relationship between social constraints and quality of life verified the mediating effect of illness perceptions and the fear of cancer recurrence on this relationship. Social constraints affect the quality of life of HCT survivors via three pathways: the mediating role of illness perceptions, the mediating role of fear of cancer recurrence and the chain mediating effect of both factors.

Conclusion

The chain mediating effect of illness perceptions and the fear of cancer recurrence on quality of life indicates that these two variables have important practical significance with respect to improving HCT survivors’ physical and mental health. The study thus serves as a reference for health workers to improve HCT survivors’ quality of life in the future.
How do compulsory citizenship behaviors affect moral disengagement in organizations? Significance of anger toward the organization during the COVID-19 pandemic
Authors: Yildiz Bora , Yildiz Harun , Ozbilgin Mustafa
Published: November 2022

Background

With the COVID-19 pandemic, healthcare professionals, especially nurses, are confronted with an intensified workload. The literature on compulsory citizenship behaviors and their consequences is still far from explaining the cognitive and emotional mechanisms that underlie this relationship.

Methods

Drawing on the resource depletion theory, we unpack the mechanism by which compulsory citizenship behaviors influence moral disengagement with the mediation effects of anger toward the organization. We are reporting a cross-sectional survey of nurses (n = 294) in private and public hospitals in Istanbul, Turkey. The data analysis involved structural equation modeling and Bayesian mediation.

Results

The study revealed that compulsory citizenship behaviors positively influenced anger toward the organization and moral disengagement. Further, anger toward the organization mediates the link between compulsory citizenship behaviors and moral disengagement. Likewise, the Bayesian mediation analysis indicated that the proportion mediated (PM), which ensures a prediction of the extent to which the pathway explains the total effect through the mediation effect, was 33.74%.

Conclusion

The findings show that exposure to compulsory citizenship behaviors lead to negative emotional (anger toward to organization) and cognitive (moral disengagement) consequences in nurses.

Practical implications

Hospital managers should not force nurses to display discretionary work tasks outside their job descriptions. Providing an organizational milieu where voluntarily extra-role behaviors are encouraged may help reduce nurses’ moral disengagement and, in turn, ease their anger toward the organization.
Marked distinctions in syntactic complexity: A case of second language university learners’ and native speakers’ syntactic constructions
Authors: Lyu Jing , Chishti Muhammad Ilyas , Peng Zhibin
Published: November 2022

Existing research on syntactic complexity tends to examine diversity and complexity embedded in grammatical employments which may well be witnessed in formulations of different syntactic structures. Conceivably, the subject syntactic complexity seems to be exercised mostly by non-native speakers and writers. The present study employs pseudo-longitudinal data: essays written by undergraduate students in different levels collected at the same time. Hence, it aims at investigating the mechanism involved in the L2 production of L2 learners in terms of syntactic complexity by analyzing a corpus of non-native English-speaking learners. The research inquiry is mainly focused on investigation of significant differences in terms of syntactic complexity between writing of Japanese university students and that of native speakers, probing further into the particular dimension and level of difference. The study also traces marked variations in syntactic complexity employed by Japanese university students in different grades. Nagoya Interlanguage Corpus of English (NICE) developed by Sugiura in 2015 was employed to conduct the entire research proceedings. The corpus of the subject study comprises 339 essays written by L2 EFL learners studying in a Japanese university employing a judicious selection of quantitative measures of syntactic complexity. The results exhibited a considerable statistical difference between the writing of Japanese learners and native English writers. The findings of this study provide meaningful pedagogical implications for English teachers and textbook compilers. Japanese university students in higher grades are found to be employing more complicated and diverse syntactic structures. Conforming to the already conducted research studies with almost similar objectives, this study demonstrates the significance of using both general and more particular complexity metrics to assess syntactic development in L2.
Preliminary validation of a brief PROM assessing psychological distress in patients with malignant mesothelioma: The mesothelioma psychological distress tool—Patients
Authors: Guglielmucci Fanny , Bonafede Michela , Azzolina Danila , Marinaccio Alessandro , Franzoi Isabella Giulia , Migliore Enrica , Mensi Carolina , Chellini Elisabetta , Romeo Elisa , Grosso Federica , Granieri Antonella
Published: November 2022

Objective

Psychological suffering in malignant mesothelioma (MM) differs from that in other cancers because of its occupational etiology, and we aimed to develop specific patient-reported outcome measures to assess it.

Methods

We used a multi-method prospective observational multicentric study (N = 149), and a preliminary questionnaire validation was performed through a Bayesian approach.

Results

Item analysis showed a good internal consistency and reliability (Cronbach alpha = 0.79 [95% CI = 0.74–0.93]. Twenty of the 41 initial items were selected as posterior 95% highest density interval factor loading standardized effect size fell outside of the region of practical equivalence. Bayesian exploratory factor analysis showed a two-factor structure: (1) Trauma-related reactions (TR, 13 items) and (2) Claim for justice (CJ, 7 items), confirmed by the Bayesian confirmatory factor analysis. Latent factors were poorly correlated (Posterior median: 0.13; 95% CI = −0.079 to 0.323). The 90% root mean square error of approximation posterior median was 0.04 [90% CI = 0.03–0.58]; the 90% chi-square posterior median was 242 [90% CI = 209–287].

Conclusion

Psychological suffering in MM patients implies negative cognitive, emotional, and somatic reactions related to the traumatic impact of the disease and the need to obtain justice through economic compensation. Our findings provide preliminary evidence that the Mesothelioma Psychological Distress Tool-Patients could be a promising and reliable instrument to assess MM patients’ psychological distress.
Impact of the COVID-19 pandemic and the Russia-Ukraine war on stress and anxiety in students: A systematic review
Authors: Limone Pierpaolo , Toto Giusi Antonia , Messina Giovanni
Published: November 2022

Background

The outbreak of the COVID-19 pandemic at the end of 2019 and the Russian-Ukrainian war in February 2022 created restrictions and uncertainties that affected the general population’s mental health. One of the affected groups was students. This systematic review summarizes the current literature on the prevalence, outcomes, and interventions for stress and anxiety among university, college, graduate, or postsecondary populations.

Methods

A systematic literature search was performed on PubMed, Web of Science, Scopus, Embase, Cochrane Library, CINAHL, PsychInfo, and ProQuest, following PRISMA guidelines. Specific inclusion and exclusion criteria were applied, and screening was performed to identify the definitive studies.

Results

The prevalence of anxiety was relatively high, ranging from 88.9 to 13.63%, and the prevalence of stress ranged from 56 to 28.14%. The predictors of stress and anxiety included young age, gender being female, STEM course, loneliness, low academic level in school, urban lockdown, confinement, having a preexisting disease, having relatives or friends infected with COVID-19, and proximity to a COVID-19 zone. The predictors of stress included gender being female, living with family, living in a household with many people, being confined rather than having the freedom to relocate, proximity to confirmed cases of COVID-19, lack of access to materials on COVID-19, preexisting mental disorders, and lack of knowledge on the preventable nature of COVID-19. The sources of anxiety among the university students identified in the study included academics, postponement of graduation, cancelation or disruption of planned events, inability to achieve goals, and finances. In addition, the students used trauma-focused, forward-focused, task-oriented, emotion-oriented, and avoidance-oriented coping strategies.

Conclusion

The included studies showed that stress and anxiety increased during the pandemic and the war, with gender and uncertainty playing a critical role. The studies provide insights into the widespread use of problem-focused and task-focused coping strategies despite their impact on increasing stress and anxiety.
Biochemical, hematologic, and skeletal features associated with underweight, overweight, and eating disorders in young Korean women: A population-based study
Authors: An Zhen , Kim Kyung-Hee , Kim Mirihae , Kim Youl-Ri
Published: November 2022

Background

Extreme weight conditions in young women are associated with adverse health outcomes. Closely linked with extreme weight status, eating disorders (EDs) are associated with several medical complications and high mortality rates.

Objective

The study aimed to investigate the biochemical, hematologic, and skeletal features of young Korean women with underweight (UW) and overweight/obesity (OW) conditions, and patients with anorexia nervosa (AN) and bulimia nervosa (BN) compared to women with normal-weight (NW).

Method

A total of 808 women (mean age 22.3 ± 3.4 years) were recruited for the study, including 144 with UW status [body mass index (BMI) < 18.5 kg/m2], 364 with NW, 137 with OW or obesity (27 with obesity; BMI ≥ 25 kg/m2), 63 patients with anorexia nervosa (AN), and 100 with bulimia nervosa (BN). We measured blood pressure and performed biochemical, hematologic and bone mineral density (BMD) evaluations at the lumbar and femoral neck.

Results

Blood pressure and triiodothyronine levels were found to be lower in both ED groups and higher in the OW group, but no difference in the UW group, compared to the NW group. The aminotransferases and total cholesterol levels were higher in the ED and OW groups, compared to the NW group. Blood cell counts were decreased in the AN group, while increased in the OW group, compared to the NW group. Blood urea nitrogen was elevated in both ED groups. The UW and AN groups had lower BMD, whereas the OW group had higher BMD, compared to the NW group.

Conclusion

Our findings suggested that both ED groups were associated with decreases in the resting energy expenditure. OW status was associated with a risk of metabolic syndrome, and UW status with lower BMD in young women. Overall, the medical parameters in Korean patients with ED were similar to the patterns reported in Western samples in previous studies, with few exceptions such as potassium level in BN.
Holding on or letting go? Patient experiences of control, context, and care in oral esketamine treatment for treatment-resistant depression: A qualitative study
Authors: Breeksema Joost J. , Niemeijer Alistair , Kuin Bouwe , Veraart Jolien , Kamphuis Jeanine , Schimmel Nina , van den Brink Wim , Vermetten Eric , Schoevers Robert
Published: November 2022

Background

Ketamine and its enantiomer esketamine represent promising new treatments for treatment-resistant depression (TRD). Esketamine induces acute, transient psychoactive effects. How patients perceive esketamine treatment, and which conditions facilitate optimal outcomes, remains poorly understood. Understanding patient perspectives on these phenomena is important to identify unmet needs, which can be used to improve (es)ketamine treatments.

Aims

To explore the perspectives of TRD patients participating in “off label” oral esketamine treatment.

Materials and methods

In-depth interviews were conducted with 17 patients (11 women) after a six-week, twice-weekly esketamine treatment program, and subsequently after six months of at-home use. Interviews explored participants’ perspectives, expectations, and experiences with esketamine treatment. Audio interviews were transcribed verbatim and analysed following an Interpretative Phenomenological Analysis (IPA) framework.

Results

Key themes included overwhelming experiences; inadequate preparation; letting go of control; mood states influencing session experiences; presence and emotional support, and supportive settings. Patients’ attempts to let go and give into vs. attempts to maintain control over occasionally overwhelming experiences was a central theme. Multiple factors influenced patients’ ability to give into the experience and appeared to impact their mood and anxiety about future sessions, including level of preparation and education, physical and emotional support, and setting during the session.

Conclusion

Better preparation beforehand, an optimized treatment setting, and emotional and psychological support during (es)ketamine sessions can help patients to “let go” and may lead to better quality of care and outcomes. Recommendations to improve quality of patient care in (es)ketamine treatment are provided, including suggestions for the training of nurses and other support staff.
A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology
Authors: Mahony Caitlyn , O'Ryan Colleen
Published: November 2022

Molecular autism research is evolving toward a biopsychosocial framework that is more informed by autistic experiences. In this context, research aims are moving away from correcting external autistic behaviors and toward alleviating internal distress. Autism Spectrum Conditions (ASCs) are associated with high rates of depression, suicidality and other comorbid psychopathologies, but this relationship is poorly understood. Here, we integrate emerging characterizations of internal autistic experiences within a molecular framework to yield insight into the prevalence of psychopathology in ASC. We demonstrate that descriptions of social camouflaging and autistic burnout resonate closely with the accepted definitions for early life stress (ELS) and chronic adolescent stress (CAS). We propose that social camouflaging could be considered a distinct form of CAS that contributes to allostatic overload, culminating in a pathophysiological state that is experienced as autistic burnout. Autistic burnout is thought to contribute to psychopathology via psychological and physiological mechanisms, but these remain largely unexplored by molecular researchers. Building on converging fields in molecular neuroscience, we discuss the substantial evidence implicating mitochondrial dysfunction in ASC to propose a novel role for mitochondrial allostatic load in the relationship between autism and psychopathology. An interplay between mitochondrial, neuroimmune and neuroendocrine signaling is increasingly implicated in stress-related psychopathologies, and these molecular players are also associated with neurodevelopmental, neurophysiological and neurochemical aspects of ASC. Together, this suggests an increased exposure and underlying molecular susceptibility to ELS that increases the risk of psychopathology in ASC. This article describes an integrative framework shaped by autistic experiences that highlights novel avenues for molecular research into mechanisms that directly affect the quality of life and wellbeing of autistic individuals. Moreover, this framework emphasizes the need for increased access to diagnoses, accommodations, and resources to improve mental health outcomes in autism.
Causal relationship between particulate matter 2.5 and hypothyroidism: A two-sample Mendelian randomization study
Authors: Zhang Yuning , Liu Shouzheng , Wang Yunwen , Wang Yue
Published: November 2022

Background

Epidemiological surveys have found that particulate matter 2.5 (PM2.5) plays an important role in hypothyroidism. However, due to the methodological limitations of traditional observational studies, it is difficult to make causal inferences. In the present study, we assessed the causal association between PM2.5 concentrations and risk of hypothyroidism using two-sample Mendelian randomization (TSMR).

Methods

We performed TSMR by using aggregated data from genome-wide association studies (GWAS) on the IEU Open GWAS database. We identified seven single nucleotide polymorphisms (SNPs) associated with PM2.5 concentrations as instrumental variables (IVs). We used inverse-variance weighting (IVW) as the main analytical method, and we selected MR-Egger, weighted median, simple model, and weighted model methods for quality control.

Results

MR analysis showed that PM2.5 has a positive effect on the risk of hypothyroidism: An increase of 1 standard deviation (SD) in PM2.5 concentrations increases the risk of hypothyroidism by ~10.0% (odds ratio 1.10, 95% confidence interval 1.06–1.13, P = 2.93E-08, by IVW analysis); there was no heterogeneity or pleiotropy in the results.

Conclusion

In conclusion, increased PM2.5 concentrations are associated with an increased risk of hypothyroidism. This study provides evidence of a causal relationship between PM2.5 and the risk of hypothyroidism, so air pollution control may have important implications for the prevention of hypothyroidism.
Satisfaction of family physician team members in the context of contract system: A cross-sectional survey from Shandong Province, China
Authors: Cai Weiqin , Du Yuanze , Gao Qianqian , Gao Runguo , An Hongqing , Liu Wenwen , Han Fang , Jing Qi , Wang Chunping
Published: November 2022

Background

Family physicians play a key role in responding to the growing demand for primary healthcare due to aging. The work attitude of family physician team members (FPTMs) impacts their work efficiency and quality. Knowing how satisfied they are with their jobs can help identify potential directions and entry points for incentives. The purpose of this study is to analyze the job satisfaction status and influencing factors of grassroots health service personnel after the implementation of the family physician contract system in China.

Methods

The study conducted a cross-sectional survey with 570 FPTMs in three prefecture-level cities in the Shandong Province. Satisfaction was measured using 30 items across seven dimensions. Responses were recorded on a 5-point Likert scale. Descriptive statistical analysis was used to analyze the general information and satisfaction of FPTMs. Multiple linear regression analysis was used to analyze the factors influencing job satisfaction.

Results

The overall job satisfaction among FPTMs was not high. Among the seven dimensions, interpersonal relationships had the highest satisfaction (4.10 ± 0.78), while workload had the lowest satisfaction (3.08 ± 0.56). The satisfaction levels of the three sample regions were different, and the results were opposite to their regional economic development levels. The results of the multifactor analysis showed that gender, income level, educational background, working years, daily working hours, number of training sessions per year and the proportion of performance pay had significant impact on overall job satisfaction.

Conclusions

The development of a family physician contract system has increased the workload of FPTMs. In addition to the implementation of the new policy, attention should be paid to the workload and working attitude of family physicians. The fundamental measures should focus on attracting more personnel to work at the grassroots level by accelerating education and training to solve the problem of insufficient health personnel at the grassroots level. Simultaneously, attention should be paid to the improvement of the medical staff's salary level and the need for self-promotion, such as training.
Modeling vaccination and control strategies for outbreaks of monkeypox at gatherings
Authors: Yuan Pei , Tan Yi , Yang Liu , Aruffo Elena , Ogden Nicholas H. , Bélair Jacques , Arino Julien , Heffernan Jane , Watmough James , Carabin Hélène , Zhu Huaiping
Published: November 2022

Background

The monkeypox outbreak in non-endemic countries in recent months has led the World Health Organization (WHO) to declare a public health emergency of international concern (PHEIC). It is thought that festivals, parties, and other gatherings may have contributed to the outbreak.

Methods

We considered a hypothetical metropolitan city and modeled the transmission of the monkeypox virus in humans in a high-risk group (HRG) and a low-risk group (LRG) using a Susceptible-Exposed-Infectious-Recovered (SEIR) model and incorporated gathering events. Model simulations assessed how the vaccination strategies combined with other public health measures can contribute to mitigating or halting outbreaks from mass gathering events.

Results

The risk of a monkeypox outbreak was high when mass gathering events occurred in the absence of public health control measures. However, the outbreaks were controlled by isolating cases and vaccinating their close contacts. Furthermore, contact tracing, vaccinating, and isolating close contacts, if they can be implemented, were more effective for the containment of monkeypox transmission during summer gatherings than a broad vaccination campaign among HRG, when accounting for the low vaccination coverage in the overall population, and the time needed for the development of the immune responses. Reducing the number of attendees and effective contacts during the gathering could also prevent a burgeoning outbreak, as could restricting attendance through vaccination requirements.

Conclusion

Monkeypox outbreaks following mass gatherings can be made less likely with some restrictions on either the number and density of attendees in the gathering or vaccination requirements. The ring vaccination strategy inoculating close contacts of confirmed cases may not be enough to prevent potential outbreaks; however, mass gatherings can be rendered less risky if that strategy is combined with public health measures, including identifying and isolating cases and contact tracing. Compliance with the community and promotion of awareness are also indispensable to containing the outbreak.
Marital satisfaction in Iranian infertile women: A systematic review and meta-analysis
Authors: Tabatabaee Amir , Fallahi Arezoo , Shakeri Bahre , Baghi Vajiheh , Ghanei Gheshlagh Reza
Published: November 2022

Background

Infertility is a severe crisis in life that, in addition to creating psychological problems and disrupting a parent's identity and role, negatively impacts couples' marital satisfaction. Different studies in this field have reported different results, so this systematic review and meta-analysis was conducted to estimate the marital satisfaction standard score among infertile Iranian women.

Method

The databases of PubMed, Scopus, Web of Science, Embase, Scientific Information Database, and MagIran were searched without a time limit. We used the meta-analysis and a random-effects model to estimate the marital satisfaction pooled score. The heterogeneity of studies was examined with the I2 index and Cochrane's Q test. The correlation between the pooled score with the publication year and the mean age of women was evaluated using meta-regression. We assessed the publication bias by the Egger test.

Results

Seventeen studies with a sample size of 2,421 people were analyzed. The marital satisfaction pooled score of infertile women was 49% (95% CI: 39–60%). The marital satisfaction score in region 1 of the country (54, 95% CI: 42.7–65.3%) was higher than in other regions (45, 95% CI: 40–58%). Also, the marital satisfaction pooled score based on the Enrich scale (54, 95% CI: 39–69%) was higher than the score reported on other scales (45, 95% CI: 29–61%). Publication bias was not significant.

Conclusion

Infertile women have moderate to low marital satisfaction, rooted in the culture and context of Iranian society. It seems necessary to provide measures to strengthen marital satisfaction, strengthen family relationships and prevent family disintegration in these women.
A scientometric analysis of research trends on emerging contaminants in the field of cancer in 2012–2021
Authors: Zheng Daitian , Chen Lingzhi , Tian Huiting , Yang Qiuping , Wu Jinyao , Ji Zeqi , Cai Jiehui , Chen Yexi , Li Zhiyang
Published: November 2022

Introduction

Recently, emerging contaminants have been discovered in the aquatic environment that can cause a range of human diseases, including cancer. In this study, our scientometric analysis provides a comprehensive overview of emerging contaminants and cancer research from 2012 to 2021.

Methods

The Web of Science Core Collection Database was used to retrieve all related publications. The bibliometix R-package, CiteSpace, and VOSviewer were applied to collect information on annual citations and publications, famous journals and authors, the most productive countries and organizations, popular topics, and keywords.

Results

A total of 2378 publications were retrieved. The publication's output showed a gradual upward trend from 2012 to 2021. The most-cited paper was a review article by Vandenberg et al. that was published in 2012. According to the analysis results, the United States published the most articles. The closest collaboration was between the United States and China. Environmental Research and Science of The Total Environment published the most paper. It was Choi KC who was the most productive and had the highest h-index, g-index, and m-index among the authors. The most frequently used keywords were “exposure,” “endocrine-disrupting chemicals,” “endocrine disruptors,” “cancer,” “bisphenol-a,” and so on.

Discussion

Emerging contaminants play a significant role in cancer development. However, most studies are conducted in vivo with human cells or animal models, and relatively few are on human models. The scientometric analysis offers researchers a clear picture of the current state of research and hotspots in this field. From our study, researchers may find some hotspots that merit in-depth investigation.
Health-related behaviors and associated factors among swimming pool users in Kombolcha Town, Northeastern Ethiopia
Authors: Natnael Tarikuwa
Published: November 2022

Objective

Unhealthy behaviors during swimming exposes at risk of recreational water-associated diseases. The swimming pool users are the high-risk group for getting and transmitting the diseases. Thus, conducting a study on swimming pool users' health-related behaviors is crucial to prevent the transmission of recreational water-associated diseases.

Methods

This cross-sectional study was employed among 140 randomly selected swimming pool users from April 1st to 30th, 2021 in Kombolcha Town. Data were collected using an interviewer-administered questionnaire and an on-the-spot-observational checklist. The collected data were entered to EpiData version 4.6 and exported to SPSS version 25 for data cleaning and analysis. Determinants of health-related behaviors were identified by using a multivariable logistic regression model at ap-value < 0.05.

Results

The overall good health-related behavior among swimming pool users was 41.4% (95% CI: 33.6–49.3). Out of the total 140 swimming pool users, 55% (95% CI: 46.4–62.9) had good knowledge about health risks during swimming. Good knowledge about health risks during swimming (AOR = 9.64; 95% CI: 3.14–29.61), educational status of college or above (AOR = 6.52; 95% CI: 1.76–24.10) and age being > 28 years (AOR = 6.49; 95% CI: 2.34–18) were factors significantly associated with good health-related behaviors.

Conclusion

The finding of the study showed that the majority of the swimming pool users had poor health-related behaviors. Thus, Kombolcha Town Health Bureau and swimming pool managers should give attention to this population to enhance health-related behaviors through addressing the significant predictors.
Verification of PCSWMM's LID processes and their scalability over time and space
Authors: Zhang Zhonghao , Valeo Caterina
Published: November 2022

Introduction

This paper explores the scalability of PCSWMM's Low Impact Development (LID) modeling tools within the urban stormwater computer model.

Methods

The scalability is assessed for a variety of spatial and temporal scales and for event (50-year return storm) and continuous inputs (daily rainfall for an 11 month period), and with a focus on bioretention cells. The model is calibrated for a moderate to large scale, semi-urban watershed on Vancouver Island, British Columbia, Canada. Sensitivity analysis and specialized metrics are used to verify internal model processes at a variety of scales.

Results

With regard to spatial scaling, changes in flow path length and slope derived from Digital Elevation Models were the most impactful spatial information when modeling flood event and the model's surface layer was the dominant contributor to peak flowrate and volume mitigation by the bioretention cell. However, when modeling the continuous rainfall inputs, storage layer related parameters dominated model outputs. Aside from the soil layer's depth, soil layer parameters such as hydraulic conductivity, showed negligible influence on response to time series rainfall. Parameters that are kept static by the model such as vegetation cover, hydraulic conductivity and storage void ratio (but are naturally dynamic), were tested for their impact on response if allowed to change seasonally or with excessive loading. Runoff coefficients were greatly impacted by storage layer parameter dynamics with very little impact from vegetation. For event simulations, the berm height in the surface layer was the dominant player in reducing peak flow as well as total volume. An analysis to help illustrate sensitivity across spatial scales is proposed.

Discussion

The Spatial Dynamic Sensitivity Analysis shows that parameter sensitivity changes dynamically as LID implementation percentage changes. In particular, the clogging factor, which is a parameter associated with the storage layer, was highly influential for time series rainfall analysis. The LID model concepts in PCSWM seem appropriate for events because the surface layer dominates the response for very large storms. For smaller storms, continuous time series, and larger spatial scales, the model could be revised to better represent soil layer dynamics and vegetation cover, which were both currently inconsequential to the model's output.
Digital (in)equalities and user emancipation: Examining the potential of Adorno's maxim of Mündigkeit for critical intergenerational learning
Authors: Leontowitsch Miranda , Wolf Friedrich , Oswald Frank
Published: November 2022

The widespread use of mobile technologies has penetrated the lives of people across all age groups with the usage of smartphones and wearables appearing “natural” and without alternatives. The digitalisation of everyday life means that communication and negotiation of social and societal meanings are co-constructed by users and mobile technologies thereby blurring the boundary between on- and off-line as well as social and private spheres. At the same time, the global-market logic that has driven the extent and speed of this social transformation raises questions as to how individuals retain influence and agency over the digital technologies that have come to define both social and private spheres and that surround them at all times. Against this backdrop, this theoretical paper discusses the role of Adorno's maxim of emancipation toward autonomy (Mündigkeit) for education (Erziehung) and critical learningaboutand livingwithdigital technologies. The paper suggests a way forward through intergenerational learning as a didactical method of enhancing emancipation among younger and older generations of “users” in their joint efforts of becoming critical agents in an age of digitally enhanced data markets.
Measurement of fecal T3 metabolite levels in sheep: Analytical and biological validation of the method
Authors: Pasciu Valeria , Sotgiu Francesca Daniela , Nieddu Maria , Porcu Cristian , Berlinguer Fiammetta
Published: November 2022

Introduction

Biological sample collection from wild and farms animals is often associated with difficulties related to the handling and restraint procedures, and most of the time it could induce stress, altering the welfare and physiological homeostasis. The analysis of fecal T3 metabolites (FTMs) allows to test samples collected in a non-invasive manner, providing several information about the animal's physiological conditions and the effects related to environmental and nutritional variations. This procedure has found wide application in wild species, but less in domestic ones.

Methods

The aim of this work was to validate the use of an immuno-enzymatic competitive ELISA kit, designed for T3 quantification in human blood serum samples, for the assessment of FTMs in the sheep. For the analytical validation, precision, recovery and parallelism were evaluated; for biological validation the variations of FTMs in relation to age, sex and the physiological status of the animal were determined.

Results

After a verification of the precision (RSD % < 15%), mean recovery (75%) and parallelism (CV% < 10%), the kit was used to measure FTMs in cyclic, pregnant, and early lactating ewes as well as in rams and ewe lambs. The results showed that FTMs concentrations in pregnant ewes were significantly lower (p < 0.05) than in cyclic and early lactation ones. Furthermore, there were no significant differences in FTMs levels between ewes and rams, while in lambs FTMs levels were higher than in adults (p < 0.001).

Conclusion

In conclusion the present study demonstrates that FTMs can be reliably and accurately determined in sheep feces, using an ELISA kit formulated for human serum T3 assay. The application of this method in the livestock sector could allow to improve our knowledge about the response of animals to different physiological and environmental conditions, and thus assess their welfare.