bluuebunny/crossref_metadata_2025 huggingface dataset:
The analysis of tool vibration signals by Spectral Kurtosis and ICEEMDAN modes Energy for insert wear monitoring in turning operation
Authors: BOUHALAIS Mohamed Lamine , NOUIOUA Mourad
Published: April 2021

Surface finish quality is becoming even more critical in modern manufacturing industry. In machining processes, surface roughness is directly linked to the cutting tool condition, a worn tool generally produces low quality surfaces, incurring additional costs in material and time. Therefore, tool wear monitoring is critical for a cost-effective production line. In this paper, the feasibility of a vibration-based approach for tool wear monitoring has been checked for turning process. AISI 1045 unalloyed carbon steel has been machined with TNMG carbide insert twenty-one times for a total of 27 minutes of machining, which was a necessary amount of time to exceed (300 µm) as a flank wear threshold. Vibration signals have been acquired during the operation and then processed in order to extract a correlation between the surface roughness, tool wear level and vibration comportment. First, Spectral kurtosis has been calculated for the twenty-one performed runs, the signals has then been decomposed with ICEEMDAN, the energy of the high frequency modes has been finally calculated. The Spectral Kurtosis has allowed the locating of the optimal frequency band that contains the machining vibration signature, yet it couldn’t have been used for wear monitoring. On the other hand, the energy of optimal frequency ICEEMDAN modes has increased in direct proportion to the increase of surface roughness degradation and thus, to tool wear.
Evaluation of the acceptability of patient-reported outcome measures in women following pelvic floor procedures
Authors: Ruseckaite Rasa , Bavor Claire , Marsh Lucy , Dean Joanne , Daly Justin O , Vasiliadis Dora , Ahern Susannah
Published: April 2021

Purpose. Patient-reported outcome measures (PROMs) are valuable tools in evaluating the outcomes of surgical treatment health-related quality of life (HRQoL) of women with stress urinary incontinence (SUI), and may be incorporated into related clinical quality registries. The aim of this study was to assess the feasibility and acceptability of incorporating PROMs into the Australian Pelvic Floor Procedure Registry (APFPR). Methods. Semi-structured qualitative interviews were conducted with women with SUI (N = 12) and their managing clinicians (N = 11) in Victoria, Australia. Interview topicscovered content and face validity, appropriateness, and acceptability of three incontinence-specific, two pain, one anxiety and depression, one sexual function and one patient global impression of improvement instruments identified through the literature to determine their suitability and acceptability for the APFPR. We analysed interview data into topics using conventional content analysis.Results. Study participants agreed that PROMs were needed for the APFPR. Both participant groups suggested that some of the instruments were ambiguous, therefore, only three instruments (one incontinence-specific, sexual function and patient global impression of improvement) will be included in the APFPR. Both clinicians and women agreed it would be appropriate to answer PROMs at baseline and then at six and 12 months post-surgically. Email, phone call and mail-out of the instruments were the preferred options for administration. Conclusions. Most women and clinicians supported the feasibility of incorporating PROMs in the APFPR. Participants believed the PROMs would demonstrate useful aggregate HRQoL data, facilitate research and have potential for use in individual care.
Immunogold-labelling localization of chlorophyllase at different developmental stages of Pachira macrocarpa leaves
Authors: Lee Tzan-Chain , Lin Kuan-Hung , Chen Chang-Chang , Shih Tin-Han , Huang Meng-Yuan , Yang Chi-Ming
Published: April 2021

Background: Chlorophyllases (Chlases) are housekeeping proteins in plant cells. The dephytylating enzymes can catalyze chlorophyll (Chl) to form chlorophyllide, but the distribution of Chlases in plant cells is still an interesting debate. In this study, antibody of PmCLH2 was made and used by immunogold-labelling technique to detect the location of Chlase of Pachira macrocarpa (Pm) leaves at four developmental stages, including young, mature, yellowing, and senesced stages. Results: The transmission electron microscopy results show that Chlases were comprehensively found in portions of chloroplast, such as the inner membrane of the envelope, grana, and the thylakoid membrane of the chloroplast, cytosol, and vacuoles at young, mature, and yellowing stages of Pm leaves, but not in the cell wall, plasma membrane, mitochondria, and nucleus. Conclusions: PmChlases were mainly detected in vacuoles at the senescent stage, but a few were found in the chloroplasts. A pathway is proposed to explain the birth and death of Chl, Chlase, and chloroplasts in higher plants.
Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study
Authors: Jia Hui-Miao , Cheng Li , Weng Yi-Bing , Wang Jing-Yi , Zheng Xi , Jiang Yi-Jia , Xin Xin , Guo Shu-Yan , Chen Chao-Dong , Guo Fang-Xing , Han Yu-Zhen , Zhang Tian-En , Li Wen-Xiong
Published: April 2021

Background: Acute kidney injury (AKI) is a common disease in intensive care unit (ICU). AKI patients with non-recovery of renal function have a markedly increased risk of death compared with recovery patients. The current study aimed to explore and validate the utility of urinary cell cycle arrest biomarkers for predicting non-recovery in patients who developed AKI after ICU admission.Methods: We prospectively and consecutively enrolled 379 critically ill patients who developed AKI after admission to ICU, which divided into a derivation cohort (194 AKI patients) and a validation cohort (185 AKI patients). The biomarkers of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were detected at inclusion (day 0) and 24 hours later (day 1). immediately after AKI diagnosis. The optimal cutoff values of biomarkers for predicting non-recovery was estimated in the derivation cohort, and the predictive accuracy of the biomarkers was assessed in the validation cohort. The primary endpoint was non-recovery from AKI (within 7 days).Results: 159 of 379 (41.9 %) patients failed to recover from AKI onset, with 79 in the derivation cohort and 80 in the validation cohort. Urinary [TIMP-2]*[IGFBP7] showed a better prediction for non-recovery than TIMP-2 and IGFBP7 alone, with the AUC of 0.751 (95 % CI 0.701 - 0.852, p < 0.001) and an optimal cutoff value of 1.05 ((ng/mL)2/1000). When [TIMP-2]*[IGFBP7] combined with clinical factors of AKI diagnosed by urine output (UO) criteria, AKI stage 2-3 and nonrenal SOFA score for predicting non-recovery, the AUC was significantly improved to 0.852 (95 % CI 0.750 - 0.891, p < 0.001), which achieved the sensitivity and specificity of 88.8 % (72.9, 98.7) and 92.6 % (80.8, 100.0), respectively.Conclusion: Urinary [TIMP-2]*[IGFBP7] represents a sensitive and specific biomarker to predict failure to recover from AKI. The predictive accuracy can be improved when urinary [TIMP-2]*[IGFBP7] combines with clinical factors of AKI diagnosed by UO criteria, AKI stage 2-3 and nonrenal SOFA score.
Endothelial Cell Activation by Interleukin-1 and Extracellular Matrix Laminin-10 Occurs via the Yap Signalling Pathway
Authors: Thurgur Hannah , Penny Jeffrey , Pinteaux Emmanuel
Published: April 2021

Background: The extracellular matrix (ECM) plays an important role for normal brain functions and homeostasis, and contributes to the inflammatory response and mechanisms of brain repair after acute brain injury. We have previously reported that the ECM laminin-10 (LM-10) is a key regulator of blood-brain barrier (BBB) integrity, and is involved in BBB repair after hypoxic injury and interleukin-1 (IL-1)-induced inflammation in vitro. To further investigate the role of LM-10 in BBB inflammation and repair, we investigated for the first time the signalling mechanisms regulated by LM-10 in brain endothelial cells in response to IL-1β-induced inflammation in vitro. Methods: Human brain endothelial cell line hCMEC/D3 cultured on Matrigel- or LM-10-coated tissue culture plates were left untreated or were treated with human recombinant IL-1β at various concentrations and/or for various periods of time. In vitro hallmarks of angiogenesis were assessed using a scratch injury model and tube formation assay. Expression of cell adhesion molecules ICAM-1 and VCAM-1, as well as IL-8 was measured using ELISA. Activation of signalling pathways ERK1/2, p38, NF-κB and YAP was assessed by quantitative ELISA or Western blot. Activation of genes downstream of YAP signalling was assessed by quantitative polymerase chain reaction.Results: LM-10 promoted endothelial proliferation and subsequent repair of an endothelial monolayer after scratch injury, induced tube formation, and upregulated IL-1β-induced ICAM-1 and VCAM-1 expression in vitro. Classical IL-1β-induced signalling pathway ERK1/2 and p38 were not modulated by LM-10, whilst LM-10 upregulated IL-1β-induced NF-κB activation. Importantly, we demonstrate for the first time a role of the YAP signalling pathway in endothelial cell activation, in that LM-10 significantly downregulates p-YAP (S397) activation without affecting phosphorylation of YAP (S127), leading to differential expression of YAP target genes, ctgf and serpine-1 involved in endothelial cell activation. Conclusion: Our study provides for the first time evidence that the YAP signalling pathway is an important regulator of endothelial cell activation, and could be a new therapeutic target for the treatment of cerebrovascular inflammatory diseases.
Cross-cultural Adaptation and Validation of the Arabic Version of the Harrus Hip Score
Authors: Alshaygy Ibrahim , Alageel Musab Abdulaziz , Aljurayyan Abdulaziz , Griffen Anthony , Arafah Orfan , Nasse Ahmed bin , Alsudairi Abdulaziz , Alsubaie Mohammed , Almousa Yasmeen , Alyousef Nada , Aljasser Fawzi
Published: April 2021

Background: The goal of this study was to translate the Harris Hip (HHS) questionnaire into the Arabic language with cross-cultural adaptation to include and benefit Arabic speaking communities as it is the most widely used instrument for disease-specific hip joint evaluation and measurement of total hip arthroplasty outcome. Methods: This questionnaire was translated following A clear and user-friendly guideline protocol. The Cronbach’s alpha was used to assess the reliability and internal consistency of the items of HHS. Additionally, The constructive validity of HHS was evaluated against the 36-Item Short Form Survey (SF 36). Results: A total of 100 participants were included in this study, of which 30 participants were re-evaluated for reliability testing. Cronbach’s alpha of the total score of Arabic HHS is 0.528 and after the standardization, it changed to 0.742 which is within the recommended range (0.7-0.9). Lastly, The correlation between HHS and SF 36 was r=0.71 (p<0.001) which represents a strong correlation between Arabic HHS and SF-36. Conclusion: Based on the results, we believe that the Arabic HHS can be used by clinicians, researchers, and patients to evaluate and report hip pathologies and total hip arthroplasty treatment efficacy.
Patient's Perceived Empathy Can Predict Doctor-patient Relationship in Medical Interaction in China
Authors: HAN Caixia , WU Qing , LIU CHENCHEN , WANG Pei
Published: April 2021

ObjectiveTo explore the relationship among patient perception of doctors' empathy, doctor-patient communication, and doctor-patient relationship.MethodsFrom November 2019 to April 2020, we used the CARE scale, the SEGUE framework and the PDRQ-15 scale to survey 3,039 patients from 14 provinces in China, ranging in age from 18 to 92 years old.Results1. The age of the patient, the level and type of hospital, the length of consultation, and the presence or absence of verbal and physical conflict have significant differences in the scores of perceived empathy; 2. There was a significantly positive correlation among patient's perceived empathy, doctor-patient communication, and the doctor-patient relationship (r = 0.65 ~ 0.75, p < 0.001). 3. The patient's perception of doctor empathy can not only directly predict doctor-patient relationship (β = 0.75, p < 0.001), but also influence doctor-patient relationship through the mediating effect of doctor-patient communication (β = 0.56, p < 0.001). Besides, the scores of CARE can effectively explain the variation of each stage of doctor-patient communication skills (R2 = 0.28 ~ 0.37) and the satisfaction (52%) and approachability (54%) of the doctor-patient relationship scale.ConclusionThe age of the patient, the type and level of the hospital, and the consultation time affected perceived empathy. Doctor-patient communication plays a partial mediating effect in the influence of empathy on the doctor-patient relationship.Practice implicationsMedical institutes should improve the medical environment and carry out humanistic education and patient-centered communication skills training for doctors. These approaches will enhance patients' perceived empathy and therefore improve the doctor-patient relationship.
Early response of methanogenic archaea to H2 as evaluated by metagenomics and metatranscriptomics
Authors: Kakuk Balázs , Wirth Roland , Maróti Gergely , Márk Szuhaj , Rakhely Gábor , Laczi Krisztián , Kovács Kornél Lajos , Bagi Zoltán
Published: April 2021

Background.

The detailed molecular machinery of the complex microbiological cell factory of biogas/biomethane production is not fully understood. One of the main puzzling process control elements is the formation, consumption and regulatory role of hydrogen (H2). Reduction of carbon dioxide (CO2) by H2 is rate limiting factor in methanogenesis, but the community intends to keep H2 concentration low in order to maintain the redox balance of the overall system. H2 metabolism in methanogens becomes increasingly important in the Power-to-Gas renewable energy conversion and storage technologies.
Results.

The early response of the mixed mesophilic microbial community to H2 gas injection was investigated with the goal of uncovering the first responses of the microbial community in the CH4 formation and CO2 mitigation Power-to-Gas process. The overall microbial composition changes, following a 10 min H2 injection by excessive bubbling of H2 through the reactor, was investigated via metagenome and metatranscriptome sequencing. The overall composition and taxonomic abundance of the biogas producing anaerobic community did not change appreciably two hours after the H2 treatment, indicating that this time period was too short to display differences in the proliferation of the members of the microbial community. There was, however, a substantial increase in the expression of genes related to hydrogenotrophic methanogenesis of certain groups of Archaea. H2 injection also altered the metabolism of a number of microbes belonging in the kingdom Bacteria. The importance of syntrophic cross-kingdom interactions in H2 metabolism and the effects on the related Power-to-Gas process are discussed.
Conclusion

s. External H2 regulates the functional activity of certain Bacteria and Archaea. Mixed communities are recommended for the large scale Power-to-Gas process rather than single hydrogenotrophic methanogen strains. Fast and reproducible response from the microbial community can be exploited in turn-off and turn-on of the Power-to-Gas microbial cell factories.
Ultrasonic-Assisted Drilling of Cortical and Cancellous Bone in a Comparative Point of View
Authors: Pourgiv Sousan , Jamshidi Nima , Mohammadi Aminollah , Mosavar Alireza
Published: April 2021

Background: A potential method in drilling of bone is ultrasonic-assisted drilling. In addition, during the drilling of bone, which is common in clinical surgeries, excessive heat generation and drilling force may lead to damages in bone tissue, and thus to failure of implants and fixation screws or delay in healing process. The aim of this study was to appraise efficiency of ultrasonic-assisted drilling in comparison to conventional drilling.Methods: In addition to investigating drilling force and temperature elevation, their effects on arising osteonecrosis and micro-cracks were explored in ultrasonic-assisted and conventional drilling through histopathologic assessment and microscopic imaging. In this regard, three drilling speeds and two drilling feed-rates were considered as drilling variables in the in-vitro experiments. Moreover, numerical modeling gave an insight into temperature distribution during drilling process in the both methods and compared three different vibration amplitudes. Results: Although temperature elevations were lower in the conventional drilling, the ultrasonic-assisted drilling had lesser drilling forces. Furthermore, the latter method had smaller osteonecrosis regions, and did not have micro-cracks in cortical bone and destructions in structure of cancellous bone.Conclusions: The ultrasonic-assisted drilling, which caused lesser damages to the bone tissue in both cortical and cancellous bone, was more comparatively advantageous.
Influence of clear cell carcinoma on the post-hepatectomy prognosis of patients with hepatocellular carcinoma
Authors: Deng Yongheng , Zhu Shaoliang , Qi Lunan , Chen Zushun , Ma Liang
Published: April 2021

Background To evaluate whether the presence of clear cell carcinoma in patients with hepatocellular carcinoma affects their prognosis after hepatectomy.Methods Data were retrospectively analyzed for 470 patients with hepatocellular carcinoma, of whom 239 also had clear cell carcinoma. All patients were treated by hepatectomy at our hospital between October 2007 and March 2020. Overall survival (OS) and disease-free survival (DFS) were compared between patients with or without clear cell carcinoma. A Cox proportional hazards model was used to identify factors independently associated with survival. A nomogram was formulated to predict long-term prognosis of patients with hepatocellular carcinoma containing clear cell carcinoma following hepatectomy.Results The presence of clear cell carcinoma was associated with significantly higher DFS (P = 0.007) and OS (P < 0.001). Multivariate analysis identified the following factors as significantly associated with DFS: alpha-fetoprotein level (AFP), tumor size, liver cirrhosis, satellite nodules and portal vein tumor thrombosis (PVTT). The following factors were significantly associated with OS: tumor size, satellite nodules, capsule formation and Ki-67. A nomogram incorporating these independent prognostic factors showed a concordance index of 0.660 for predicting DFS and an index of 0.730 for predicting OS.Conclusion Clear cell carcinoma is associated with better post-resection prognosis of patients with hepatocellular carcinoma. Tumor size and satellite nodules may be independent predictors of OS and DFS.
Clinical Whole-Exome Sequencing Analysis Reveals a Novel Missense COL11A1 Mutation Resulting in an 18-Week Iranian Male Aborted Fetus with Fibrochondrogenesis 1: A Case Report
Authors: Mirtavoos-Mahyari Hanifeh , Ajami Sanaz , Mehrtash Amirhosein , Marashiyan Seyedeh Mahya , Bahreini Farbod , Sheikhy Kambiz , Ghanbari Sogol , Ardeshirdavani Amin
Published: April 2021

BackgroundFibrochondrogenesis 1, an autosomal recessive syndrome, is an infrequent and rare disease, causing short-limbed skeletal dysplasia. This syndrome is clinically characterized and distinguished by a small nose and anteverted bares, flat midface, shortened long bones, and a protuberant abdomen. Mutations in the gene encoding the α1 chain of type XI collagen (COL11A1) are seen to be the main cause of this disease.Case PresentationWe present an 18-week Iranian male aborted fetus with Fibrochondrogenesis 1 from consanguineous parents. Whole-exome sequencing (WES) revealed a novel missense variant from G to A in exon 45 of 68 in the COL11A1 gene (NM_080629.2: c.3440G>A, [p.G1147E, g.103404625]). The mutation was confirmed by Sanger sequencing and further, MutationTaster predicted this variant to be disease-causing.Conclusion﻿Bioinformatic analysis suggests that this variant is highly conserved in both nucleotide and protein levels, suggesting that it has an important function in the proper role of COL11A1 protein. In-silico analysis suggests that this mutation alters the COL11A1 protein structure through a Glycine to Glutamic acid substitution. This is a novel mutation and a rare variant as this variant is not reported in gmomAD, ExAC, or 1000 genome databases.To the best of the authors’ knowledge, this is the first study to report a novel pathogenic mutation in COL11A1 in association with Fibrochondrogenesis 1. Therefore, we suggest that WES can be used as a robust method to achieve rapid diagnosis and identification of pathogenic and novel mutations in patients.
Clinical Application and Technical Details of Cook Zenith Devices modification to treat Urgent and Elective Complex Aortic Aneurysms
Authors: Manunga Jesse , Jordan Lia , Mirza Aleem K. , Teng Xiaoyi , Skeik Nedaa , Eisenmenger Laura
Published: April 2021

Purpose: To describe technical details of modifying four different Cook Zenith devices to treat complex aortic aneurysms.Material: In the first three cases, the modification process involved complete stent graft deployment on a sterile back table. Fenestrations were created using an ophthalmologic cautery and reinforced with a radiopaque snare using a double-armed 4-0 Ethibond locking suture based on measurements obtained on centerline of flow. In each instance, a nitinol wire was withdrawn and redirected through and through the fabric and used as a constraining wire. In the fourth patient, modification involved partial stent graft deployment and creation of additional two fenestrations to accommodate renal arteries. The devices are resheathed and implanted in the standard fashion.Results: Four patients underwent exclusion of their aneurysms, including thoracoabdominal aneurysms (n=2), a contained ruptured juxtarenal aneurysm (n=1), and a ruptured failed previous endovascular repair (n=1). Fifteen fenestrations were successfully bridged with Atrium iCAST stent grafts. Average graft modification time, operative time, contrast volume, radiation dose, estimated blood loss, and hospital length of stay were 89 minutes, 155.25 minutes, 58.8 mL, 2451 mGy, 175 mL, and 4.3 days, respectively. One patient required a secondary intervention to treat a type Ib endoleak. During an average follow-up of 25 months, aneurysm sacs progressively shrank without additional intervention.Conclusion: Physician-modified fenestrated/branched endografts are a safe alternative to custom made devices, especially in urgent cases and should be part of the armamentarium of any complex aortic program.
Time makes histone H3 modifications drift
Authors: Hillje Roman , Luzi Lucilla , Amatori Stefano , Fanelli Mirco , Pelicci Pier Giuseppe , Giorgio Marco
Published: April 2021

To disclose the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. The comparison of different age profiles of histone H3 marks revealed global redistribution of histone H3 modifications with time, in particular in intergenic regions and near transcription start sites, as well as altered correlation between the profiles of different histone modifications. Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, preserved younger state of histone H3 in these genomic regions.
Association between triglyceride glucose index and abdominal aortic calcification
Authors: Liu Yihai , Wu Mingyue , Xu Biao , Kang Lina
Published: April 2021

Background

The triglyceride glucose (TyG) index has been regarded as a simple surrogate marker of insulin resistance. However, few studies have investigated the relationship between the TyG index and abdominal aortic calcification (AAC), an independent predictor of atherosclerotic vascular diseases and mortality.
Methods

A total of 1486 participants with comleted AAC records from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 were enrolled. Baseline variables and abdominal dual-energy X-ray absorptiometry (DXA) data were collected. The TyG index was calculated as ln[triglycerides (mg/dL)×glucose (mg/dL)/2], and the presence of AAC was defined as AAC score > 0.
Results

The participants were 58.8 ± 12.2 year old and 48.6% (722/1486) were male. TyG level was positively correlated with the presence of AAC (β = 1.37, [1.15–1.63]; p < 0.001). The highest quartile of TyG was associated with 1.83-fold (odds ratio [OR]: 1.31–2.58; p < 0.001) risk of AAC compared with the lowest quantile. After adjusted for lifestyles, comorbidities and calcium metabolism factors, higher TyG level was significantly and linearly associated with higher AAC prevalence. The multivariate-adjusted OR and 95% confidence interval (CI) were 2.12 (1.05–4.35; p = 0.038) for participants within the highest quantile and 1.60 (1.07–2.41; p = 0.022) per one-unit incresement. Subgroup analysis showed that the association between TyG and AAC was still significant across groups except for age > 60.
Conclusions

Higher TyG index was significantly associated with the higher presence of AAC, which could be a marker of AAC.
Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps
Authors: Ghorbani Mahla , Azghandi Marjan , Khayyami Reza , Baharara Javad , Kerachian Mohammad Amin
Published: April 2021

Background: The incidence of colorectal cancer (CRC) has increased during recent years in Iran and other developing countries. Clinical studies suggest that essential folate dietary intake and moderate deficiency of methylenetetrahydrofolate reductase (MTHFR) may protect and reduce the risk of CRC.The aim of the present study was to investigate the clinical significance of C677T polymorphism within MTHFR gene and its correlation with the serum folate and Vit B12 in the Iranian population suffering from CRC.Methods: Blood samples were taken from 1017 Iranian individuals (517 cases and 500 controls) who were referred for colonoscopy. TaqMan probe assay was performed for C677T MTHFR polymorphism. Sera were fractionated from the blood samples of 43 patients and controls and folate and Vit B12 concentrations were measured by a monobind kit. The correlation of MTHFR polymorphisms and folate/vitamin-B12 with CRC risk were analyzed.Results: In the current study, we found the frequency of three different genotypes of MTHFR polymorphism in the Iranian population i.e., CC, CT and TT, to be 51.31, 26.73, 21.96 and 61, 32.2, 6.8 in case and control groups, respectively. The homozygote genotype of MTHFR rs1801133 polymorphism is associated with increased risk of CRC by 3.68, 1.42 and 3.74-fold in codominant, dominant and recessive models respectively (p value< 0.01). Our study revealed that there was no significant difference between the amount of folate and Vit B12 in case and control groups (p value> 0.05).Conclusions: This study revealed that there was no significant difference between the amount of folate and Vit B12 in the case and control groups. Furthermore, our results demonstrated a higher risk association for 677TT and 677TT+C677T genotypes of MTHFR compared with 677CC carriers among CRC patients.
Lipstick on pigs: Critical discourse and image analysis of non-humans in U.S. children’s ESL textbooks
Authors: Burden Amy
Published: April 2021

Gender equality in language learning has received considerable attention in research on classroom policy and materials. Within studies of materials like language learning texts, most research focuses on content analyses of character roles and images, with sometimes purposeful exclusion of non-human characters. However, non-humans in children’s picture books comprise almost 60% of the characters children read. Therefore, their representations of gender, including biases, overt sexism, and covert sexism should be examined. In this study, I examine gendering of non-human characters using corpus linguistics and critical discourse analysis. Additionally, I use critical image analysis to discuss pictorial gendering of non-human characters within 12 textbooks in two of the United States’ most widely used textbook series for language learning in elementary schools. Results indicate a strong preference for aggressive and adventurous male characters, male supremacist ideologies, and the suppression of female agency.
Recensione: Pavesi, Maria, & Ghia, Elisa (2020). Informal contact with English. A case study of Italian postgraduate students. Edizioni ETS.
Authors: Staggini Giulia
Published: April 2021

Informal Contact with English. A case study of Italian postgraduate students tratta dell’acquisizione informale della lingua inglese in contesto italiano. Il volume, infatti, dopo una rassegna dei principali studi acquisizionali attorno al tema, illustra e descrive i risultati dell’indagine condotta su studenti dell’Università di Pavia riguardo al loro rapporto con media e input in lingua inglese. Il testo presenta un focus specifico sui benefici e sull’impatto dei testi audiovisivi in generale, e dei testi audiovisivi sottotitolati in particolare.
Contemporary Issues in Well-being of Undergraduate Clinical Students: A Systematic Review
Authors: Tze Lin Chong , Wee Ming Lau , Kyi Kyi Tha
Published: April 2021

Well-being is a complex concept with objective and subjective elements that contribute to life satisfaction. Medical students experience inevitable transition from pre-clinical to clinical training with increasingly more independence and responsibility. This study aimed to identify well-being issues in undergraduate clinical students. The emotional, physical, social, spiritual, occupational and intellectual aspects of well-being were focused on. A thorough literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies reporting issues from the six aspects of well-being in undergraduate clinical students, and published in peer-reviewed journals in English language from the year 2000 to 2020 with full-text available online were included. The initial search from PubMed, OVID Medline, Psych INFO and CINAHL Plus retrieved 623 articles with 51 studies included in this review. Evidence from the previous studies demonstrated poor well-being among undergraduate clinical students. Stress, lack of exercise, low peer and family support, and mistreatment by clinicians and patients were common well-being issues encountered. Based on this literature review, the five aspects of well-being except the emotional aspect were less explored. Thus, it will be of interest to investigate well-being issues among Malaysian undergraduate clinical students from the physical and occupational aspects, which are further impacted by the COVID-19 pandemic, and to identify possible contributing factors. Undergraduate clinical students are faced with several well-being issues. Thus, early detection of these issues is important to avoid devastating consequences to students and patients.
Tackling Neurophobia among Medical Professionals from Its Inception: Role of Medical Curriculum to Treat This Epidemic Phenomenon
Authors: Omar Noor Azzizah
Published: April 2021

Neurophobia is a term used to describe the fear of any topic related to neurology due to failure to integrate basic science knowledge to clinical situation. It has been found that majority of first liner medical staff felt less confident in dealing with patients with neurological illness. This is rather alarming since as the improvement of medical facilities in the recent decade, the age span of the population increases hence, so does their related neurological diseases. Probing into this phobia among the medical professionals has led to one common problem-their undergraduate experience. It has documented that high percentage of disinterest to neurological subject due to its teaching methods and the complexity of the topics. The aim of the study was to discuss on various teaching strategies to overcome this phobia. It has been found that vertical and horizontal integration has been beneficial in augmenting students understanding and retention of knowledge. Thus, it has been implemented and suggested as the suitable curriculum format in medical undergraduate programme. Apart from that, in coherence of IR 4.0 era, there are many innovative teaching techniques that have been studied over the years to facilitate teaching and promote students’ motivation towards neurological topics. However, some traditional sessions such as dissections classes still are very much relevant in pre-clinical teaching sessions. Neurophobia has been an “epidemic disease” for decades. The role of tailoring teaching methods to meet with the current students’ need has shown promising result to tackle this issue.
To estimation of polarization characteristics of the medium on the data of multi-frequency measurements in the method alternating current resistance
Authors:   Bulashevich Institute of Geophysics of the Ural Branch of RAS, Ekaterinburg, Russia, SHESTAKOV Aleksey Fedorovich
Published: April 2021

The relevance of the work is due to the need to extract additional information in the study of the polarization properties of the geological environment from experimental data in the method of ac resistance using multifrequency measurements. The introduction provides a brief review of the literature on the problem of studying the polarization properties of rocks in the frequency domain and the method of frequency dispersion, which is successfully used in prospecting and exploration works in sulfide and copper pyrite deposits. The questions of determining the polarizability of the medium in the frequency domain and the parameter of the polarization process depending on the structural and petrophysical characteristics are discussed. Purpose of this research is to compare the characteristic features of studying the polarization properties of a medium in the frequency domain and to establish the relationship between polarizability and the frequency dispersion coefficient of electrical resistance. To propose an algorithm for determining the polarization characteristics of a medium from the data of multifrequency measurements in the method of resistances on alternating current. Research methodology: substantiation of the choice of the model of induced electric polarization in the frequency domain and the peculiarities of its application to establish the relationship between the frequency dispersion coefficient and the apparent polarizability of the medium. Research methods: theoretical calculations and comparative analysis of the obtained dependences on the model parameters. Results of work. The choice of the model of induced electric polarization Cole-Cole in the frequency domain is substantiated to establish a relationship between the frequency dispersion coefficient and the apparent polarizability of the medium. The possibility of using multifrequency measurements of electrical resistance to study the polarization characteristics of a medium based on this model is shown. An algorithm has been developed and expressions have been obtained that make it possible to determine the polarizability of the medium and the parameter of the relaxation time from the data of measuring the apparent resistance at three frequencies in the method of electric sounding on alternating current. Application area. The obtained results can find application in the processing of data from conductive electrical soundings on alternating current, for the correct interpretation of the frequency effect and the study of the polarization properties of the medium, in particular, when research by the method of frequency dispersion.
Sidorsky deposit of construction sands in the Volgograd region
Authors:   Volgograd State Technical University, Volgograd, Russia, KNYAZEV Aleksandr Petrovich , KALINOVSKIY Sergey Andreevich ,   Volgograd State Technical University, Volgograd, Russia, KNYAZEV Yuriy Petrovich ,   Volgograd State Technical University, Volgograd, Russia, PRISTANSKOV Andrey Aleksandrovich ,   Volgograd State Technical University, Volgograd, Russia
Published: April 2021

Relevance of the research. Construction sands are the largest functional group of sands widely used in construction industry. This natural material is one of the most demanded for the production of manufactured products in the construction industry of the region. Purpose of the researchis to study the engineering-geological conditions of construction sands deposit for the production of the manufactured products of OAO Sebryakovsky plant of asbestos-cement products, as well as for construction organizations of the region. Research methods. Based on the analysis of extensive collection materials using laboratory and statistical methods, as well as the results of additional research, the physical-geographical, engineering-geological and technogenic conditions of the study area were examined. Results and their application. The useful stratum of the deposit is composed of Upper Quaternary alluvial sands, the average thickness of which is 8.6 m, penetrated thickness is up to 12.3 m. Overburden within the study area is represented by the soil-vegetation horizon – up to 0.2 m. The extracted raw materials are used in the production of mortars, which is confirmed by tests of a cement-sand grout, and as a filler in fine-grained concrete. The reserves of the deposit are calculated in categories A + B + C1 in the amount of 2313.2 thousand m3. The development of the deposit is recommended by the open method. Explored and recoverable reserves will ensure the operation of the enterprise with an annual demand of 100 thousand m3 per year for a period up to 2030. Conclusions. Based on the results of the studies, it should be noted that the Sidorsky deposit of construction sands is assessed as profitable and competitive in relation to the exploited deposits of sand in the Volgograd region.
Quantification of recoverable oil reserves in the S6, S7 and S8 sands, in the Sigmoilina zone, at the Jusepin field in the Orinoco oil and gas basin, Venezuela
Authors:   Academy of Engineering. Peoples’ Friendship University of Russia, Moscow, Russia, RODRIGUEZ LINARES Adrián José , KARELINA Elena Viktorovna ,   Academy of Engineering. Peoples’ Friendship University of Russia, Moscow, Russia
Published: April 2021

Relevance of the work. Quantifying these oil reserves allows Venezuela to lead the ranking as the country with the largest oil reserves worldwide Purpose of the work. Is related to the need of quantification in the recoverable oil reserves in the field of Husepin (Monagas state, Venezuela) for the oil industry. The methodology of the research. The La Pica 01 Field is made up of 509 wells, of which 49 wells were used to elaborate the correlations, since they have spontaneous potential and resistivity curves. For each well, the tops and bases of the units were determined by analyzing the behavior of the electrical responses of each of the sands, applying the basic concepts of stratigraphy, as well as a detailed compilation of all the information that corresponds to the wells that form part of the study to obtain a standard record that contains all the favorable data and be able to carry out the correlations. Research results. In the S6 sand, 4 oil deposits were found and an Original Oil In Place of 15,875.32 thousands of normal barrels and recoverable reserves of 2,857. 5576 thousands of normal barrels were estimated. For S8 sand, 5 oil fields were defined and an Original Oil In Place of 25,940.86 thousands of normal barrels and recoverable reserves of 4,669. 3548 thousands of normal barrels were estimated. Original Oil In Place was not calculated in the S7 sand because it has no deposits. Recommendations. Review the production history and verify which wells can be re-incorporated into an oil extraction plan and Submit the reserves of the study fields to the Ministry of Popular Power for Energy and Petroleum (MENPET) taking into account the results obtained in this investigation. Conclusions. 4 oil deposits were found in the S6 sand and 5 oil deposits were found in the S8 sand and each of them were with stratigraphic limits, structural limits and fluid contact. No oil deposits were found in the S7 sand, although records have been taken in the northwest of the field show thicknesses of ANP at this stratigraphic level. Keywords: oil reserves, Orinoco basin, Sigmoilina zone, well, deposit.
Pengaruh Pembelajaran Berbasis Permainan Online Terhadap Kecerdasan Fisik Motorik Anak Usia Dini
Authors: Kustiawan Andri Arif , Aulia Enggarwati Shinta
Published: April 2021

Technology is developing very rapidly so that it can simplify human work, both science, information, games, buying and selling, and so on on the internet. Apart from having an impact on the fast and easy access to information, it also has an impact on health, social, intelligence, psychological, financial and other aspects. It is excessive if it is overused to make it addictive. Such as addiction to online games, TikTok, and youtube which results in dependence and underestimates health and time. This research uses literacy studies. The purpose of this study is to present findings of the impact of gadget use on children. The results show that technological advances have both positive and negative impacts. There are various kinds of game applications that are easily accessed by children, both game content and those that can stimulate children's development, such as creativity, memory, physical motor, cognitive and so on. So it is necessary to take preventive steps so that technological developments can also reduce the negative impact on children's development.
Impact of COVID-19 Pandemic on COMPI Fertility Problem Stress Scale and the State-Trait Anxiety Scale in Patients Undergoing IVF/ICSI
Authors: Yurci Arzu , Karayagiz Saban
Published: April 2021

OBJECTIVE: This study aimed to investigate the effect of the COVID-19 outbreak on infertile couples dealing with stress and anxiety during in vitro fertilization treatment.
STUDY DESIGN: 252 infertile patients who applied for in vitro fertilization treatment were included in this cross-sectional study. Data were collected via four data collection tools including socio-demographic form, COVID-19 Inventory (COVID-I), COMPI fertility problem stress scale (COMPI-FPSS), and state-trait anxiety scale. Data analysis was conducted by SPSS statistical software included statistical analysis such as averages, standard deviations, correlation, regression, and t-test.
RESULTS: Both negative and weak correlations were found between COMPI fertility problem stress scale and subscales of state-trait anxiety scale as well as the total score of state-trait anxiety scale. In terms of socio-demographic characteristics of the participants and their responses in state-trait anxiety scale and ISS forms, the correlation coefficients were also so low. The results also showed that public officials, health professionals, and educators showed lower state-trait anxiety scale (stress-related anxiety) scores.
CONCLUSION: During the COVID-19 pandemic, there was an increase in spontaneous pregnancy expectations. Although participants were mostly stressed because of the COVID-19 outbreak, they didn’t change their in vitro fertilization treatment plans during the outbreak.
Papież Franciszek jako sędzia w procesie o stwierdzenie nieważności małżeństwa
Authors: Gałkowski Tomasz
Published: April 2021

Tematem opracowania jest analiza wyroku wydanego przez papieża Franciszka w procesie skróconym przed biskupem. Autor omawia jego kolejne etapy zwracając swoją uwagę na te elementy prawne i teologiczne, które mogą stać się przydatne w aplikacji norm przez biskupów.
Tytuły prawne, z których mogłyby być prowadzone sprawy o stwierdzenie nieważności małżeństwa, w których istotną rolę odegrała akrotomofilia
Authors: Szymańska Kinga
Published: April 2021

In the presented study, the author reflects on the nature of acrotomophilia in the context of conducting a trial in a church court. The analyzes show that in the case of acrotomophilia, we are dealing with a serious sexual disorder. The conducted analyzes show that acrotomophilia may have a destructive influence on marital life, leading to its breakdown. Hence, this study shows that in church courts, marriage nullity cases could be conducted out of consensual incapacity (can. 1095, n. 2-3 CCI) and deception (can. 1098 CCI).
Dorobek kanonistyki uprawianej na Katolickim Uniwersytecie Lubelskim w przedmiocie materialnego prawa małżeńskiego w okresie międzywojnia (1918-1939)
Authors: Dzierżon Ginter
Published: April 2021

W prezentowanym opracowaniu przedmiotem uwagi Autora stała się problematyka dorobku kanonistyki uprawianej na Katolickim Uniwersytecie Lubelskim w przedmiocie materialnego prawa małżeńskiego w okresie międzywojnia (1918-1939). Badając spuściznę materialną na którą złożyły się opublikowane monografie pracowników i studentów tego ośrodka naukowego, prace zbiorowe oraz artykuły dowiódł, iż uczeni ci kategorycznie sprzeciwiali się rządowemu laickiemu projektowi reformy osobowego prawa małżeńskiego, broniąc katolickiej nauki o małżeństwie. Znalazło to w sposób szczególny wyraz w dwóch pozycjach, jakimi były prace zbiorowe: „Małżeństwo w świetle nauki katolickiej” oraz „Rozbiór krytyczny projektu prawa małżeńskiego uchwalonego przez K. K”.

Ustosunkowując się do poziomu merytorycznego publikacji Autor wykazał, iż są one oparte na solidnym materiale źródłowych i literaturze przedmiotu. W opinii Autora, na szczególną uwagę zasługują: doktorat Piotra Bobera „Pojęcie tajnej przeszkody małżeńskiej w prawie kanonicznym” oraz praca licencjacka Teodora Benscha „Wpływ chorób umysłowych na ważność umowy małżeńskiej w prawie kanonicznem”. W obu bowiem pozycjach kanoniści podjęli tematykę w owych czasach na wskroś nowatorską wieńcząc wyniki swych badań rzetelnymi podsumowaniami.
10.2174/0250688202666210402094638
Authors: Mahadevappa Manjappa , Kulkarni Prashanth , Poornima KS , Prasad Rajendra
Published: April 2021

Background:

Lactic acidosis of any etiology is associated with poor prognosis and often fatal. The survival in lactic acidosis depends on the ability to identify
and remove the cause and managing organ perfusion. Nucleoside Reverse Transcriptase Inhibitors (NRTIs), which are used widely in the treatment
of Human Immune Deficiency Virus (HIV) infection, are known to cause life-threatening Type B lactic acidosis.

Case Presentation:

Severe lactic acidosis can cause organ failure, especially in respiratory and cardiovascular systems. However, the role of acute lactic acidosis in
these organ failures is mostly suggested by experimental studies in animals or in vitro, as few clinical studies in humans are available. Acidosis
elevates pulmonary vascular resistance, giving rise to pulmonary hypertension and peripheral vasodilation with an associated fall in blood pressure
and systemic hypotension. Although lactic acidosis presenting as abdominal pain, vomiting, and pancreatitis have been reported in persons
receiving antiretroviral therapy, the presentation as acute right heart failure has rarely been documented in the literature. We report a case of severe
metabolic and lactic acidosis in a patient receiving stavudine and lamivudine, with a rare and atypical presentation as acute right heart failure and
severe pulmonary hypertension.

Conclusion:

This case emphasizes the need to consider lactic acidosis as a potential cause in patients presenting with acute unexplained right heart failure and
severe pulmonary hypertension.