bluuebunny/crossref_metadata_2025 huggingface dataset:
James Guillaume et l’historiographie de la pédagogie des Lumières et de la Révolution française dans le contexte du centenaire de 1889
Authors: Buttier Jean-Charles
Published: January 2023

Antiautoritaire, membre de l’AIT puis l’un des dirigeants de la Fédération jurassienne en Suisse romande, James Guillaume s’est fait historien de l’école par ses nombreux articles dans le Dictionnaire de pédagogie et d’instruction primaire et en éditant les procès-verbaux des comités d’instruction publique pour le Centenaire de 1889. Son apport spécifique, qui souligne l’importance de Pestalozzi, est comparé avec celui de Gabriel Compayré, historien de l’école majeur des débuts de la Troisième République.
Les potentialités critiques de l’ Aufklärung
Authors: Jean Anne
Published: January 2023

Dans La dialectique de la raison , Horkheimer et Adorno utilisent un concept large et transhistorique « d’ Aufklärung  », en la faisant remonter à l’Antiquité et en la définissant comme la pensée qui libère les hommes de la crainte de la nature à travers sa domination. La domination de la nature devient nécessairement domination de soi et des autres hommes ; le concept d’ Aufklärung est dialectique parce qu’il contient les germes de son autodestruction. Cependant, les usages que les auteurs font de Hobbes dans La dialectique de la raison révèlent l’ambivalence des « Lumières ». D’une part, ils montrent que sa théorie absolutiste manifeste la tendance autoritaire de la raison. D’autre part, ils mettent au jour la puissance critique de sa philosophie : son hypothèse de l’état de nature dévoile les antagonismes qui sévissent au sein de la société bourgeoise capitaliste. La lucidité de Hobbes, l’un des « écrivains sombres de la bourgeoisie », est un signe de l’existence des potentialités critiques propres à l’ Aufklärung .
Montesquieu : de la souveraineté despotique à la souveraineté républicaine
Authors: Terrel Jean
Published: January 2023

À la différence de Bodin et surtout de Hobbes, Montesquieu distingue des formes de gouvernement et non de souveraineté. Avant L’Esprit de lois , Il réserve généralement le vocabulaire de la souveraineté aux régimes despotiques, aux monarchies qui tendent à le devenir et aux républiques qui gouvernent de manière despotique leurs conquêtes. Or dans l’ Esprit des lois , la souveraineté est d’abord propre aux républiques et en particulier aux démocraties antiques. Il faut en rendre compte.
Que reste-t-il des Lumières ? Les droits de l’homme à l’épreuve des études postcoloniales
Authors: Spector Céline
Published: January 2023

Cette contribution est consacrée à la critique post-coloniale de la Déclaration des droits de l’homme et du citoyen de 1789. L’octroi des droits dépend-il de certaines conditions, comme le développement de la raison – ce qui supposerait un processus préalable de « civilisation » ? Il conviendra également de faire droit à l’idée selon laquelle l’« individualisme possessif » a imprégné l’esprit des Déclarations au point de justifier la dépossession des nations sans État ni droit de propriété. Enfin, l’article tentera de réfuter la thèse selon laquelle la philosophie des droits de l’homme, développée au sein de grandes puissances coloniales esclavagistes, est ipso facto illégitime.
L’héritage des Lumières dans la controverse sur le célibat et le mariage des prêtres. L’actualité d’un débat
Authors: Grasso Grazia
Published: January 2023

Jusqu’à récemment, il aurait semblé étrange d’associer le terme de “Lumières” à celui de catholicisme, tellement les deux réalités semblent s’opposer. Maintenant c’est une thèse sereinement acceptée que les Lumières ont joué un rôle central aussi bien dans le domaine de la religion qu’au sein des Églises. L’article étudie la controverse sur le célibat des prêtres, dont on demande l’abolition au sein des Lumières catholiques italiennes, et qui s’inscrit dans un débat plus large sur la nature humaine, la sexualité et la nécessité d’une réforme de l’Église.
La présence noire et métisse en Franche-Comté à la fin de l’Ancien Régime
Authors: Thiou Éric
Published: January 2023

Cet article évoque deux enquêtes ministérielles, apparemment inédites, trouvées dans les fonds de l’Intendance de Franche-Comté aux Archives du Doubs grâce auxquelles nous avons connaissance de la présence de personnes noires ou métisses sur le territoire de la Franche-Comté, province éloignée des métropoles et des ports du royaume. La première est à l’initiative du duc de Choiseul en 1763, et la seconde du ministre de la Marine, M. de Sartine en 1775-1776, dont j’expose ici les résultats. Ces enquêtes ont sans doute été lancées nationalement mais elles ne sont pas signalées dans l’ouvrage de Bertrand Gille, « Les sources statistiques de l’histoire de France – Des enquêtes du xvii e  siècle à 1870 ». Celle de 1775-1776 a participé à l’élaboration de la déclaration du roi pour la police des noirs du 9 août 1777. Enfin, sera évoqué le cahier de doléances de la commune de Champagney (Haute-Saône) qui condamne énergiquement l’esclavage et réclame son abolition dans une région où la mainmorte sévit encore.
Éduquer à la compassion. Martha Nussbaum au prisme de Rousseau
Authors: Lenne-Cornuez Johanna
Published: January 2023

Au sein de son entreprise de revalorisation morale des émotions, Martha Nussbaum reconnaît sa dette à l’égard de Rousseau. Cette contribution entend cependant montrer que la philosophe américaine réduit certains apports de la philosophie rousseauiste à une réflexion sur la juste formation des sentiments empathiques. Non seulement Rousseau permet de mieux cerner les critères de définition de la compassion que Nussbaum ne l’accorde, mais en faisant de ce sentiment un aiguillon de la critique sociale, il offre aussi une réflexion sur les bornes morales et politiques de ce dernier.
Le rose des Lumières (identités visuelle, sociale et sexuée du rose)
Authors: Gaillard Aurélia
Published: January 2023

L’étude montre comment le rose, en tant que terme de couleur et aussi en tant que sensation chromatique, est une couleur propre au xviii e  siècle. À partir de là, la contribution s’attache à analyser la mode et l’imaginaire du rose à l’époque des Lumières en dégageant son identité visuelle, sociale et sexuée. Le rose est ainsi une couleur carnée, liée au toucher et à la peau, elle est un signe de distinction sociale, aristocratique, et dès ce siècle, contrairement à la thèse consensuelle, elle devient un marqueur de distinction sexuée.
Un cas extrême de fétichisme chromatique : du Cunto de li cunti de G. Basile (1636) à « Incarnat, blanc et noir » (anonyme, 1731)
Authors: Defrance Anne
Published: January 2023

Le conte de fées « Incarnat, blanc et noir » ( Nouveau Recueil de contes de fées ) est la réécriture de deux contes de Giambattista Basile : « Le corbeau » et surtout « Les trois cédrats ». Leur scène inaugurale rend hommage au pouvoir de la couleur : une vision colorée produit un choc émotionnel si puissant sur le héros qu’il engendre une fixation érotique déterminant toute l’intrigue. On montrera, par un parcours croisé dans ces trois contes, comment la fiction merveilleuse, terrain de prédilection du fantasme, offre à certaines questions esthétiques une riche réverbération allégorique.
Foucher de Careil (1826-1891), éditeur et interprète des écrits de Leibniz sur Spinoza
Authors: Lalanne Arnaud
Published: January 2023

Dans un contexte marqué par le primat du spiritualisme et de la lecture de Descartes par Victor Cousin, Foucher de Careil tente une interprétation du rapport entre Spinoza et Leibniz à partir du naturalisme cartésien. Les annotations sur Wachter découvertes par Foucher de Careil servent de point d’appui à sa lecture d’une réfutation dirigée contre le fondement cartésien du naturalisme « outré » de Spinoza.
Further Considerations on the Question of Deleuze’s Neo-Leibnizianism
Authors: Geretto Mattia
Published: January 2023

La relation de Deleuze avec l’histoire de la philosophie et avec Leibniz en particulier est une relation qui se développe pendant plus de vingt ans et nous permet de situer la question du néo-leibnizisme dans le cadre plus large du « style », du « vol » et de la manière de faire de la philosophie par Deleuze. Cette contribution souligne que le terme néo-leibnizianisme est inventé selon Deleuze pour indiquer sa propre philosophie. La réinterprétation de la métaphysique de Leibniz par Deleuze – une réinterprétation également influencée par des auteurs tels que Simondon, Péguy et Ruyer –, est analysée à travers le remaniement de certains concepts clés tels que les « singularités pré-individuelles », la « vice-diction », la théorie de l’événement et le « chaosmos ». Enfin, cette réinterprétation se cristallise dans une ontologie de « capture » et « inclusion », qui remplacent les variables leibniziennes de « clôture » et de « sélection ». Dans le seul plan transcendantal admis par Deleuze, la monade et l’événement même deviennent « un passage de Dieu », ouvrant la voie d’une manière originale dans la même ontologie de Deleuze à une suggestive et problématique théologique de l’immanence.
Le prix de morale de l’Académie de Dijon pour l’année 1750 : le Discours sur les sciences et les arts de Rousseau dans le contexte des concours académiques
Authors: Urmann Martin
Published: January 2023

L’article, qui paraîtra en deux sections dans cette revue, porte un regard nouveau sur le Discours sur les sciences et les arts de Rousseau en examinant le contexte central qui est le prix de morale proposé par l’Académie de Dijon pour l’année 1750. Dans la première partie, l’article analyse les critères du jury dans l’évaluation du concours et puis considère notamment les manuscrits des concurrent(e)s de Rousseau, lesquels ont été presque entièrement ignorés à ce jour par la recherche établie en histoire de la littérature et de la philosophie.
Les sérails dans les Lettres persanes
Authors: Kra Pauline
Published: January 2023

Les Lettres persanes sont structurées par les sérails d’Usbek et d’Anaïs. Le sérail d’Usbek indique la route de la révolte et de la destruction. Celui inspiré par Anaïs esquisse la voie de la réforme et de la liberté. Il s’agit ici d’en rappeler les implications.
Instabilité énonciative et hiérarchie des valeurs dans l’ Histoire véritable : l’effet-personnage et la projection sensorielle chez Montesquieu
Authors: Magnot-Ogilvy Florence
Published: January 2023

L’article part de la narrativité problématique de l’ Histoire véritable qui partage avec les  Lettres persanes une discontinuité narrative et une multiplicité des points de vue. L’instabilité énonciative de ces deux textes y fragilise la notion de personnage. Il s’agit de montrer comment un système de valeurs est véhiculé sans passer par l’identité d’un personnage mais en se fondant sur l’évocation d’une sensorialité commune au vivant, qu’il s’agisse d’humain ou de non humain comme c’est le cas en particulier dans l’ Histoire véritable grâce au procédé de la métempsycose. L’ Histoire véritable , au même titre que les Lettres persanes , illustre ainsi la manière dont l’écriture de Montesquieu interroge les mécanismes de projection dans l’altérité à travers des dispositifs fictionnels qui ne sont pas centrés autour de la notion de personnage.
Comparison of Refractive Prediction Accuracy With Three Optical Devices
Authors: Cheng Shi-Ming , Li Xi , Zhang Jia-Sheng , Mei Jian-qi , Shi Gui-lian , Lin Junhai , Li Tian-tian , Yu A-Yong
Published: January 2023

Purpose:

To investigate refractive prediction accuracy with the OA-2000 (Tomey), Anterion (Heidelberg Engineering), and IOLMaster 500 (Carl Zeiss Meditec AG) in patients with cataract.

Methods:

Patients with cataract referred for phacoemulsification were enrolled and scanned with the OA-2000, Anterion, and IOLMaster 500 in random order. The success rate of axial length (AL) measurements per device was calculated and a chi-square test was used to identify the differences in acquisition rate between the three devices. The Bland-Altman method was used to appraise the agreement of biometric parameters between the three devices. Four different formulas (Barrett Universal II [BUII], Haigis, Holladay 1, and SRK/T) were included in the study. The parameters of refractive prediction accuracy comprised predictive error (PE), absolute PE (AE), and percentages of eyes with a PE within ±0.50, ±0.75, and ±1.00 diopters (D).

Results:

The acquisition rates of AL measurements with the OA-2000 and Anterion were 97.35% and 94.70%, respectively (chi-square = 3.82,
P
> .05). A significantly lower acquisition rate of 84.82% was obtained with the IOLMaster 500 compared with the other two devices (
P
< .05). Bland-Altman analysis identified good agreement between the three biometers with narrow 95% limits of agreement for flat and steep keratometry (K1 and K2), anterior chamber depth (ACD), and AL. For PE, only the differences between the Anterion and IOLMaster 500 with the Barrett UII and Haigis formulas were statistically significant (
P
< .05). The three devices revealed no statistically significant differences in MAE, MedAE, and the proportion of eyes with a PE within ±0.50, ±0.75, and ±1.00 D (
P
> .05).

Conclusions:

The OA-2000 and Anterion showed a similarly higher acquisition rate of AL measurements than the IOLMaster 500 in patients with cataract. Good agreement for K1, K2, ACD, and AL was found between the three biometers. Regarding refractive prediction accuracy, the Anterion did not significantly outperform both the OA-2000 and IOLMaster 500.

[
J Refract Surg
. 2023;39(1):48–55.]
Exploring Older Adult Health Literacy in the Day-to-Day Management of Polypharmacy and Making Decisions About Deprescribing: A Mixed Methods Study
Authors: Gillespie Robyn , Mullan Judy , Harrison Lindsey
Published: January 2023

Background:

Polypharmacy use in older adults is increasing and sometimes leads to poor health outcomes. The influence of health literacy in managing polypharmacy and making decisions about stopping medication has received limited attention.

Objective:

A mixed methods design was used to measure and investigate the influence of health literacy in the management of polypharmacy and decisions about deprescribing. Phase 1 involved two cross-sectional surveys, one with older adults using five or more medications and the other with general practitioners (GPs).

Methods:

Older adult health literacy was measured using the All Aspects of Health Literacy Scale. Phase 2 employed individual interviews with both older adults and GPs and further explored the reported use of health literacy in practice. SPSS version 24 was used to conduct descriptive statistical analysis of the Phase 1 survey responses and Phase 2 interviews were analyzed using thematic analysis with the assistance of NVivo 12.

Key Results:

Phase 1 survey responses were received from 85 GPs and 137 older adults. Phase 2 interviews were conducted with 16 GPs and 25 older adults. Phase 1 results indicated that self-reported older adult health literacy was high, and that GPs believed older patients could engage in decisions about deprescribing. Phase 2 findings showed that older adults developed and employed complex health literacy practices to manage medications between consultations; however, few reported using their health literacy skills in consultations with their GPs. GPs noted that older adult involvement in decision-making varied and generally thought that older adults had low health literacy.

Conclusion:

Older adults reported using health literacy practices in the management of their sometimes-complex medication regimens. However, the role of health literacy in deprescribing decision-making was limited. The mixed methods approach allowed greater insight into older adult and GP practices that influence the acquisition and use of health literacy. [

HLRP: Health Literacy Research and Practice
. 2023;7(1):e14–e25.

]

Plain Language Summary:

This report explores health literacy in the use of multiple medications and decisions to stop using medication/s in older age. Older adults reported good heath literacy and practiced many health literacy skills in the management of their medications. However, they did not always report the use of their health literacy skills when discussing their medications with their family doctor.
Materialización arquitectónica de la rābiṭa en época almohade a través de las hagiografías y algunos restos constructivos
Authors: Almela Iñigo
Published: January 2023

El presente trabajo pretende seguir reflexionando sobre un tema de amplia discusión a lo largo de las últimas décadas, pero que continúa albergando múltiples incertidumbres. Las rábitas del Magreb y al-Andalus son todavía un tema que requiere nuevos estudios y perspectivas, especialmente en lo que atañe a su materialidad. Por este motivo, en primer lugar, se ha tratado de obtener información de las fuentes hagiográficas y se ha analizado con el fin de filtrar todos aquellos datos que sirvan para aproximarnos a sus funciones y las actividades que acogían. A continuación, se ha confrontado este material con la información descriptiva que ofrecen los libros de habices de Granada y con algunos ejemplos de interés cuyas características espaciales son parcialmente conocidas. Todo ello con el fin de aproximarnos, en la medida de lo posible, a este tipo de edificaciones y conocer su morfología durante la etapa almohade.
El viajero, la fiebre héctica y las horas. Estudio introductorio de un consilium médico de Mateo Boldieri (s. XV)
Authors: Alonso Guardo Alberto
Published: January 2023

Se estudia un consilium médico sobre la fiebre héctica escrito por el veronés Mateo Boldieri, profesor de medicina en la Universidad de Padua durante el siglo XV. La obra expone el tratamiento que un paciente predispuesto a dicha enfermedad debe seguir durante la realización de un viaje. Analizamos la estructura y contenido de la obra, investigamos las características del caso clínico a la luz de los datos extraídos de la misma y, por último, examinamos el sistema horario empleado en el régimen que debe seguir el destinatario.
Las fuentes de Tuseredo (Díaz 388) y el tratado Serpens ille veternosus (CPL 1263)
Authors: Varela Rodríguez Joel
Published: January 2023

En el presente artículo se estudian las fuentes patrísticas del Rescriptum de Tuseredo (siglo VIII), que presentan algunos problemas: en algunos casos no está clara la procedencia de dichas fuentes; en otros, la fuente original fue objeto de intervenciones deliberadas por parte del autor. Por otra parte, se identifica como testimonio seguro de Fortleben de Tuseredo el anónimo tratado Serpens ille veternosus, confirmando así una propuesta aducida en su momento por Madoz. El asunto da pie a proponer una datación más precisa para el Serpens ille veternosus, discutir sus posibles autorías y analizar el contexto en el que éste pudo haber sido escrito.
La implantación del notariado público en el reino de Murcia (1256-1305)
Authors: Vigil Montes Néstor
Published: January 2023

La implantación del notariado público en el reino de Murcia es un interesante ejemplo del modelo de rápido establecimiento del oficio ex novo, propio de los territorios recién conquistados en la Península Ibérica durante el siglo XIII, el cual fue estudiado para los casos de Sevilla, Córdoba, Valencia y Mallorca. Mediante el análisis de la legislación y de los documentos notariales conservados, pretendemos analizar los paralelismos y las divergencias con esos otros casos peninsulares, las características particulares de la mezcla de contingentes repobladores procedentes tanto de la Corona de Castilla como de la Corona de Aragón y la adaptación del notariado público a los cambios políticos acaecidos en el reino de Murcia durante el siglo XIII.
Problematic screen media use in children and adolescents attending child and adolescent psychiatric services in a tertiary care center in North India
Authors: Raju Venkatesh , Sharma Akhilesh , Shah Ruchita , Tangella Ravikanth , Yumnam Sana Devi , Singh Jyoti , Yadav Jaivinder , Grover Sandeep
Published: January 2023

Objective:

The present clinic-based study aimed to evaluate screen media use among children and adolescents who had a mental disorder.

Methods:

Two hundred twelve parents of children and adolescents attending the child and adolescent psychiatric services were approached. They were asked to rate the screen media use of their child brought for psychiatric consultation using the Problematic Media Use Measure-Short Form (PMUM-SF). The DSM-5 criteria of internet gaming disorder (IGD) were applied using the PMUM-SF, which contained nine items equivalent to nine items of IGD.

Results:

The mean age of the patients was 13.16 years (SD: 4.06; range: 0.8–18). Only 28.3% (n = 60) were aged less than 12 years. The most common primary diagnosis was neurodevelopment disorder (n = 82; 38.7%), followed by neurotic disorder (n = 62; 29.2%) and mood disorder (n = 30; 14.2%). The most common screen media used was television (n = 121; 57.1%) followed by the mobile phone (n = 81; 38.2%). The average screen time was 3.14 hours, with a range of 0.5–7 hours, and more than two-third of children and adolescents used screen gadgets for more than the recommended duration. Slightly more than one-fourth (22.2%) of children and adolescents with mental disorders fulfilled the DSM-5 criteria of IGD. When those with and without screen media addiction were compared, those with screen media addiction were more often male, from joint or extended families, more often diagnosed with neurodevelopmental disorders and disruptive disorder, and were less often diagnosed with neurotic disorders.

Conclusion:

About one-fourth of the children and adolescents with mental disorders had screen media addiction, and two-thirds of them used screen media for more than the recommended duration.
Prevalence of negative mental health status during COVID-19 pandemic among general population of seven Arab countries: A cross-sectional study of 28843 participants
Authors: Abdelsattar Nada K. , Alrawi Aya Ghiath , Abdelraoof Mohamed Ibrahim , Zaazouee Mohamed S. , Elsayed Sarah Makram , Farhat Abdullah M. , El-Shafea Mahmoud Abd , Abdeltawab Ahmed K. , Ali Menna S. , Madeeh Alyaa K. , Assar Ahmed , Mohammed Manar H. , Abdullah Eman A. , Ragab Khaled M. , Abd-ElGawad Mohamed , Elsherif Mohamed , Rahim Inas Abd El , Ebada Mahmoud A.
Published: January 2023

Background:

Previous studies documented a narrow scope of knowledge about the negative mental health status during the lockdown following the COVID-19 pandemic, especially in Arab countries.

Aim:

We aimed to assess the association between negative mental health status and the COVID-19 pandemic and determine the different factors affecting mental health among the general population of seven Arab countries.

Methods:

This study is a multinational cross-sectional questionnaire-based survey conducted online from June 11, 2020 to June 25, 2020. The depression, anxiety, and stress Scale 21 Items (DASS-21) and the Event scale–Revised Arabic version (IES-R-13) scales were used. Multiple linear regressions were performed to study the association between the scales’ total scores with COVID-19 and demographic characteristics.

Results:

A total of 28,843 participants from seven Arab countries were included. During the COVID-19 pandemic, the prevalence of mental health disorders has significantly increased. A total of 19006 participants (66%) were affected by variable degrees of depression, 13,688 (47%) had anxiety, and 14,374 (50%) had stress ranging from mild to severe. Higher levels were associated with other factors, such as lower age, female gender, chronic disease, unemployed, fear of getting infected, and a history of psychiatric disorders.

Conclusion:

Our study findings show an increased incidence of mental disorders during the pandemic. This is expected to play a crucial role in guiding a psychological support strategy provided by healthcare systems to the general public during pandemics.
Publication of studies registered in Clinical Trials Registry of India: An audit of mood disorder research protocols from 2009-2019
Authors: Menon Vikas , Varadharajan Natarajan , Joseph Rini , Praharaj Samir Kumar , Andrade Chittaranjan
Published: January 2023

Background:

Selective publication of studies has important scientific, ethical, and public health implications.

Aim:

We studied selective publication among mood disorder research protocols registered in the Clinical Trials Registry of India (CTRI) database. We also examined the frequency and nature of protocol deviations among the published articles.

Methods:

Using a systematic search strategy, we examined the publication status of all mood disorder-related research protocols registered in the CTRI database from inception till December 31, 2019. Logistic regression analysis was used to identify variables associated with selective publication.

Results:

Of 129 eligible protocols identified, only a third (n = 43, 33.3%) were published in literature; among those published, only 28 (21.7%) were placed in MEDLINE indexed journals. Protocol deviations were observed in more than half of the published papers (n = 25, 58.1%); many of these (41.9%) were related to sample size deviations, though, importantly, deviations in primary and secondary outcomes were also noted (16.2%). Retrospective registration of trials (odds ratio, 2.98, 95% confidence interval, 1.32–6.71) was significantly associated with publication; other variables, such as funding status or multicentric sampling, were not associated with eventual publication.

Conclusions:

Two out of three mood disorder research protocols registered in India do not translate into published research. These findings from a low- and middle-income country with limited spending on health care research and development represent wastage of resources and raise scientific and ethical concerns about unpublished data and futile patient participation in research.
Evidence-based integration of yoga in psychiatric practice
Authors: Gangadhar B. N.
Published: January 2023

Yoga has been put to test in clinical medicine to build evidence. There has been a steep rise in yoga research through 2010, threefold in the next decade. Despite challenges, clinicians have explored yoga intervention in several disorders. The available data have been examined using meta-analysis when there are more studies. Psychiatric disorders treated with yoga have attracted more research. Some examples include depression, schizophrenia, anxiety, obsessive–compulsive disorder (OCD), somatoform pain, addiction, mild cognitive impairment, and elderly and childhood disorders. Current manuscript focuses on highlighting the major steps towards generating evidence that have led to integration of yoga into psychiatry practice. It also discusses various challenges and the way forward.
Predictive value of hepatic venous pressure gradient and efficacy and significance of early PTVE for gastrointestinal bleeding after TACE for liver cancer
Authors: Wei Jian , Hu Yuefeng , Yu Jianan , Yin Chao , Chen Guang , Jin Long
Published: January 2023

Aims:

To investigate the predictive value of hepatic venous pressure gradient (HVPG) and the efficacy and significance of early percutaneous transhepatic varices embolization (PTVE) for gastrointestinal bleeding after transcatheter arterial chemoembolization (TACE) for liver cancer.

Methods and Materials:

This retrospective study enrolled 60 patients diagnosed with stage B or stage C liver cancer, according to the Barcelona Clinic Liver Cancer (BCLC) staging system, between December 2019 and October 2021. TACE and HVPG measurement (>16 mmHg or >20 mmHg) were performed on all 60 patients, who were randomized into control and experimental (PTVE) groups. All patients were followed up for 12 months.

Statistical Analysis Used:

SPSS 20.0 software was used for data analysis. The two groups were compared with respect to the initial occurrence time of hemorrhage after TACE, recurrence time of hemorrhage, liver function, TACE frequency, TACE type, and tumor control.

Results:

The initial hemorrhage rates at one, three, six, and 12 months after TACE were 3.2%, 12.9%, 22.6%, and 48.4%, respectively, in the control group (n = 31) and 0%, 0%, 3.4%, and 10.3%, respectively, in the PTVE group (n = 29). Differences between the groups in terms of initial hemorrhage rate at six and 12 months postoperatively were significant (P < 0.05). The recurrence rates of hemorrhage at one, three, six, and 12 months after TACE were 11.1%, 22.2%, 22.2%, and 33.3%, respectively, in 27 patients in the control group. In eight patients in the PTVE group, the corresponding rates were 0%, 0%, 0%, and 25.0%. The differences between the groups in the recurrence rate of hemorrhage at the four time points were significant (P < 0.05). At six months postoperatively, liver function recovery and remission were noted in eight (25.8%) and 18 (66.7%) patients, respectively, in the control group; these events were noted in 10 (34.5%) and 19 patients (65.5%), respectively, in the PTVE group, and the difference between the groups was not significant (P > 0.05). In the control group, TACE was performed for a total of 94 times on 31 patients within 12 months, including conventional transcatheter arterial chemoembolization (C-TACE, 75.5%) and the drug-eluting bead TACE (DEB-TACE, 24.5%); the objective response rate (ORR) was 39.3%. In the PTVE group, TACE was performed for a total of 151 times on 29 patients within 12 months, with an average of 5.21 times on each patient, including the C-TACE (57.6%) and DEB-TACE (42.4%); the ORR was 60.1%. Differences in TACE frequency, proportion of C-TACE/DEB-TACE, and ORR were significant between the two groups (P < 0.05).

Conclusion:

HVPG can accurately evaluate gastrointestinal bleeding after TACE in patients with liver cancer. Early PTVE can significantly lower the risk of gastrointestinal bleeding and help TACE control tumor progression in patients with an HVPG >16 mmHg or >20 mmHg.
Preoperative tumor abnormal protein is a promising biomarker for predicting hepatocellular carcinoma oncological outcome following curative resection
Authors: Cai Huayong , Li Wenxin , Zhang Yu , Hua Xiangdong
Published: January 2023

Introduction and Objectives:

The objective of this study was to explore the potential relationship between tumor abnormal protein (TAP) and the prognosis of hepatocellular carcinoma (HCC) after a radical hepatectomy.

Patients or Materials and Methods:

This retrospective study included 168 HCC patients (tumor recurrence in 78 patients) who underwent a curative resection from January 2018 to June 2020. The whole population was categorized into a TAP high (≥224.6 μm2) or a TAP low group (<224.6 μm2).

Results:

There was no correlation between maximum tumor size and TAP. In the whole population or subgroups stratified by maximum tumor size, the recurrence-free survival (RFS) rate of the TAP low group was significantly higher than TAP high group (P < 0.05 for all). The multivariate analysis revealed that TAP (hazard ratio [HR], 3.47; 95% confidence interval [CI], 2.18–5.51; P < 0.001), large tumor size (HR, 2.18; 95% CI, 1.36–3.49; P < 0.001), poor tumor differentiation (HR, 0.53; 95% CI, 0.33–0.84; P = 0.007), and presence of microvascular invasion (MVI) (HR, 2.03; 95% CI, 1.28–3.22; P = 0.003) were independently associated with RFS. The prognostic implication of the nomogram incorporating TAP, maximum tumor diameter, tumor differentiation, and MVI was stronger than the model without TAP.

Conclusion:

The present study suggests that higher preoperative TAP is correlated with undesirable prognosis in HCC patients who underwent a radical hepatectomy. Our study provides a robust nomogram for RFS of postoperative HCC patients.
Clinical guidelines for microwave ablation of spinal metastases
Authors: Yang Tao , Ke Jin , Cheng Shi , He Yue , Huang Wenhan , Yao Mengyu , Zhou Jielong , Zhong Guoqing , Hu Yongcheng , Zhang Yu
Published: January 2023

Spinal metastases are the most common source of morbidity in patients with cancer. Recently, microwave ablation has produced satisfactory results in the management of spinal metastases. However, there is still controversy in terms of clinical treatment, such as indication, power, time, and temperature. To standardize the application of microwave ablation technology and reduce the risk of surgical-related complications in spinal metastases, in this report, we aimed to summarize the current evidence and clinical experience of microwave ablation and developed a clinical guideline, initiated by the Musculoskeletal Tumor Group of the Committee for Minimally Invasive Therapy in Oncology of the Chinese Anti-Cancer Association. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used in to rate the quality of evidence and the strength of recommendations, and the Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist was strictly followed to report the guideline. Finally, 15 evidence-based recommendations were formulated based on the 15 most concerned clinical questions among orthopedic surgeons, oncologists, and interventional radiologists in China. This guideline aims to promote the science-based normalization of microwave ablation for the treatment of spinal metastases.
Covid – 19 infection and treatment
Authors: Okeahialam Basil N.
Published: January 2023

COVID-19 infection was declared a pandemic by the World Health Organization due to its widespread nature and devastating effect on health, demography, and economics all over the world. The disease has evolved fast, changing treatment paradigms as its pathophysiology became clearer. Lately, a vaccine was introduced, and its effects and efficacy have come to be a thing of challenge as experience continues to be gained. In this case report, the author shares his experience of unfolding scenarios with treatment of the disease in his clinical environment.
Genitourinary cancer
Authors: Khajuria Atul , Kushte Shilpa S
Published: January 2023

Genitourinary (GU) malignancy comprises nearly half of the cancers diagnosed in men, and the incidence of this group of cancers increases with age. The key to successful management is to define appropriate goals (cure vs. palliation) based on the history and extent of disease, physiology and life expectancy of the patients, and cost–benefit ratio of treatment options. Recently, a number of genomic and molecular studies have provided an insight into the oncogenesis and progression of GU cancers, particularly bladder, prostate, and kidney cancers. These comprehensive innovative analyses have led to new molecular classification based on the genomic expression profiles and the discovery of potential diagnostic and therapeutic molecular targets.
Conjunctival inflammation and dry eye symptoms at day 100 post-transplantation do not predict risk for chronic graft-versus-host disease
Authors: Shah Ankit M , Galor Anat , Mones Karla , Jean Pepita , Komanduri Krishna V , Wang Trent P
Published: January 2023

PURPOSE:

Chronic graft-versus-host disease (cGVHD) is a significant cause of morbidity and mortality among patients after allogeneic hematopoietic stem cell transplant (HCT). The objective of our study was to determine if early assessment of matrix metalloproteinase-9 (MMP-9) and dry eye (DE) symptoms (via the DE Questionnaire-5 [DEQ-5]) had prognostic utility for the development of cGVHD and/or severe DE symptoms after HCT.

MATERIALS AND METHODS:

This was a retrospective study of 25 individuals who underwent HCT and had MMP-9 (InflammaDry) and DEQ-5 performed on day 100 post-HCT (D + 100). Patients also completed the DEQ-5 at 6, 9, and 12 months post-HCT. The development of cGVHD was determined by chart review.

RESULTS:

Overall, 28% of patients developed cGVHD over a median follow-up of 229 days. At D + 100, 32% of patients had a positive MMP-9 in at least one eye and 20% had a DEQ-5 ≥6. However, neither the presence of a positive MMP-9 nor a DEQ-5 score ≥6 at D + 100 predicted the development of cGVHD (MMP-9: hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 0.34-6.85, P = 0.58; DEQ-5 ≥6: HR: 1.00, 95% CI: 0.12-8.32, P = 1.00). In addition, neither of these measures predicted the development of severe DE symptoms (DEQ-5 ≥12) over time (MMP-9: HR: 1.77, 95% CI: 0.24-12.89, P = 0.58; DEQ-5 >6: HR: 0.03, 95% CI: 0.00-889.93, P = 0.49).

CONCLUSION:

Within our small cohort, DEQ-5 and MMP-9 assessment at D + 100 did not predict the development of cGVHD or severe DE symptoms.
Denosumab's Therapeutic Effect for Future Osteosarcopenia Therapy : A Systematic Review and Meta-Analysis
Authors: Aryana I Gusti Putu Suka , Rini Sandra Surya , Setiati Siti
Published: January 2023

Background: Osteosarcopenia, a combination of osteopenia/osteoporosis and sarcopenia, is a common condition among older adults. While numerous studies and meta-analyses have been conducted on the treatment of osteoporosis, the pharmacological treatment of osteosarcopenia still lacks evidence. Denosumab, a human monoclonal antibody, has shown encouraging results for the treatment of osteosarcopenia. Our systematic review and meta-analysis aimed to investigate the potential dual role of denosumab as an anti-resorptive agent and for other beneficial muscle-related effects in patients with osteosarcopenia, and to evaluate whether denosumab can be a treatment of choice compared to bisphosphonate. Methods: Relevant literature was collated from the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Google Scholar databases. The primary outcome was denosumab’s effect on lumbar spine bone mineral density (LS BMD), handgrip strength, and gait speed change. The secondary outcome was the effect of denosumab on appendicular lean mass (ALM). The outcomes were presented as mean difference (MD). A random effects model was used in the analysis to represent the population. The risk of bias was assessed using funnel plots.Results: Out of the 3,074 studies found, four full-text studies met the inclusion criteria, including 264 and 244 participants in the intervention and control groups, respectively. Regarding a primary outcome, our meta-analysis showed that denosumab showed no significant differences in LS BMD and gait speed changes compared to other agents—MD=0.37, 95% confidence interval (CI), -0.35 to 0.79; p=0.09 and MD=0.11; 95% CI, -0.18 to 0.40; p=0.46, respectively. Denosumab had a significant effect on handgrip strength change compared to standard agents—MD=5.16; 95% CI, 1.38 to 18.94; p=0.007, based on the random effects model.Conclusions: Denosumab was better than bisphosphonate and placebo in improving muscle strength (handgrip strength). Therefore, denosumab may be favored in individuals with osteosarcopenia to improve muscular performance and reduce fall risk.
Center for East Asian Studies of the University of Gdańsk (2007–2022)
Authors: Zeidler Kamil , Kamień Joanna
Published: January 2023

The article presents the activities of the Center for East Asian Studies, which was established at the University of Gdansk in 2007.
Returning the Gods to the People: Heritage Restitution in Nepal
Authors: Selter Elke
Published: January 2023

Since late 2021, a new development has been taking place in Nepal. Like many governments around the world, the Nepalese authorities are also fully invested in asking for the return of their looted art held in foreign collections. Yet the policy is no longer to keep these in the country’s main museums, but rather to bring them back to the communities of origin, where they can fully take up their role as “living Gods”. With this move – which fully prioritizes intangible heritage values over tangible – a unique process is taking place that allows for reflection on what the restitution of stolen objects could be all about. In this way the case of Nepal demonstrates that the trafficking of art and its placement in museums abroad, as well as its “typical” return to museums in the source countries, are strongly influenced by Western concepts of art and conservation, often ignoring the local values of this heritage.
Colonial Booty and Its Restitution – Current Developments and New Perspectives for French Legislation in This Field
Authors: Perrot Xavier
Published: January 2023

Recent developments in French and international laws concerning the return of cultural property from formerly colonized territories are particularly rich. Most States with large collections of non-European objects are now faced with claims from the countries from which these objects were transferred. France, after having long maintained a legal stance based on strict respect of the principle of inalienability of public collections, has recently changed its position statement. In 2017, in Ouagadougou, the President Emmanuel Macron said he was in favour of returning African heritage to Africa. Three years later, on 24 December 2020, the Parliament adopted a law that partially fulfilled the President’s wish, by identifying 27 objects for return to Benin and Senegal. As this article will explain, the law’s passage was fraught, and opinions continue to diverge on a case-by-case (or object-by-object) approach to return versus a generic statute. There are also questions about what drives the idea of return – from legal responsibility, to moral duty in view of French history, to contemporary politics and diplomacy.
Znaczenie jednostek ochrony przeciwpożarowej w ochronie obiektów dziedzictwa kulturowego w zasobach lokalnych społeczności
Authors: Wolański Robert Marcin , Giełżecki Jan
Published: January 2023

W artykule przedstawiono kluczowe elementy realizacji pierwszej pomocy ratowniczej w odniesieniu do obiektów dziedzictwa kulturowego usytuowanych poza obszarami siedzib powiatów. Zwrócono uwagę na konieczność aktywnego udziału społeczności lokalnych w bieżącej ochronie obiektów dziedzictwa materialnego. Przedstawiono znaczenie udziału jednostek ochotniczych straży pożarnych w skutecznej realizacji zadań wobec zagrożeń. W krótkim opracowaniu podkreślono rolę udziału zastępów jednostek ochrony przeciwpożarowej na samochodach specjalnych z drabiną mechaniczną lub samochodów specjalnych z podnośnikiem w podawaniu prądów gaśniczych na górne elementy konstrukcji obiektów. Wskazano zabytki Szlaku Architektury Drewnianej jako obiekty szczególnie podatne na zagrożenia pożarowe i odniesiono się do możliwości skutecznej interwencji.

The importance of fire protection units in the protection of cultural heritage objects in the resources of local communities

The article presents the key elements of the implementation of first aid rescue in relation to cultural heritage objects located outside the areas of county seats. Attention was drawn to the necessity of active participation of local communities in the ongoing protection of material heritage objects. The importance of the participation of volunteer firefighting units in the effective implementation of all hazards is presented. The short paper emphasizes the role of the participation of deputies of fire protection units on special cars with a mechanical ladder or special cars with a hoist in the application of firefighting currents to the upper elements of the structure of objects. Monuments of the wooden architecture route were indicated as objects particularly susceptible to fire hazards, and reference was made to the possibility of effective intervention.
Rys historyczny oręża polskiego
Authors: Piątkiewicz Grzegorz
Published: January 2023

W artykule przedstawiono rys historyczny oręża polskiego w pięciu epokach, tj.: epoce rycerstwa, epoce wojsk zaciężnych, epoce wojska stałego, epoce wojska narodowego oraz epoce współczesnej. W obliczu dzisiejszych wydarzeń na Ukrainie polskie siły zbrojne, które są odpowiedzialne za ochronę granic, pełnią jedną z ważniejszych funkcji w państwie. Artykuł Rys historyczny oręża polskiego ma na celu wprowadzenie oraz przedstawianie czytelnikom procesu zmian zachodzących w wojsku polskim począwszy od jego początków, tj. IX wieku, a skończywszy na czasach współczesnych. Członkostwo Polski w sojuszu NATO, a także opublikowana 23 kwietnia 2022 roku ustawa o obronie Ojczyzny są w dniu dzisiejszym podstawą kierunku rozwoju Polskich Sił Zbrojnych oraz fundamentem bezpieczeństwa obywateli Rzeczpospolitej Polskiej.

Historical Outline of Polish Arms

The article presents a historical outline of Polish arms in five eras viz: The Age of Chivalry, the Age of the Armed Forces, the Age of the Regular Army, the Age of the National Army and the Modern Age. In view of today’s events in Ukraine, the Polish armed forces, which are responsible for protecting the borders, play one of the most important roles in the State. The article “A Historical outline of the Polish Armed Forces” aims to introduce and present to readers the process of changes taking place in the Polish Army starting from its beginnings, i.e. the 9th century, and ending in modern times. Poland’s membership in the NATO alliance, as well as the Law on the Defense of the Fatherland, published on 23rd April 2022, are today the basis of the direction of development of the Polish Armed Forces and the foundation of the security of the citizens of the Republic of Poland.
Comparative Analysis of Concrete Crack Detection using Image Processing and Artificial Intelligence
Authors: M N Sumaiya , K Prajwal , Vasudev Rao Shravan , K A Shreya , R Thrishul , Prasad R Manjunath
Published: January 2023

Cracks in concrete structures can be formed due to many reasons such as physical damage, hydraulic shrinkage, thermal shrinkage, swelling, and corrosion of steel reinforcements. These vulnerable entities present in structures are responsible for reducing the performance and strength of the concrete. Inspecting these entities and deciding the nature of these cracks is an essential element for the maintenance of the structure. Concrete crack detection based on Image Processing and Artificial Intelligence involves using computer vision techniques to automatically identify and classify cracks in concrete structures. Detection and classification of these cracks can be done using a combination of various machine learning algorithms and image processing techniques. Our project aims to detect the location of the cracks on the structures using various processing techniques such as resizing, gray scaling, binarization, segmentation, enhancement, and filtering out the noise. Detection of the cracks can be performed using thresholding techniques. Later classification of these detected cracks can be done using Deep Learning techniques concerning various deciding parameters such as length, width, and area of cross-section of the detected crack. The cracks can be classified based on their size they can be thin, medium, or wide cracks. They can also be classified based on the appearance of the crack, which may be longitudinal, vertical or transversal.