bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidiabetic Advancements In Silico: Pioneering Novel Heterocyclic
Derivatives through Computational Design
Authors: Mehra Anuradha , Mehra Aryan
Published: April 2024

Background::

Deficiency of insulin signaling in type 2 diabetes results from insulin
resistance or defective insulin secretion and induced hyperglycemia. By reducing glycated hemoglobin,
SGLT2 inhibitors improve hyperuricemia, blood lipids, and weight loss without increasing
the risk of hypoglycemia. By targeting this pathway, SGLT2 inhibitors can become a
prominent target in the management of type 2 diabetes.

Objective::

This study aimed to carry out the molecular docking and ADMET prediction of novel
imidazo(2,1-b)-1,3,4 thiadiazole derivatives as SGLT2 inhibitors.

Methods::

The chemical structures of 108 molecules were drawn by using ChemDraw Professional
15.0. Further, their energy minimization was also carried out by using Chem Bio Draw
three-dimensional (3D) Ultra 12.0. Molecular docking was also carried out using a Molegro Virtual
Docker to identify the best-fitting molecules and to identify the potential leads on the basis
of dock score. The predicted parameters of drug-likeness according to Lipinski’s rule of five,
such as molecular weight, log P, hydrogen bond acceptor, hydrogen bond donors, and number of
rotatable bonds of the selected compounds, were predicted using pKCSM software.

Results::

About 108 molecules were designed by employing different substitutions on imidazothiadiazole
nucleus as SGLT2 inhibitors. Out of these, 10 compounds were found to have better
interactions with the active site of SGLT2 protein and the highest dock scores compared to
canagliflozin. Compounds 39a and 39b demonstrated good interactions and the highest docking
scores of -155.428 and -142.786, respectively. The in silico physicochemical properties of the
best compounds were also determined. Additionally, these compounds suggested a good pharmacokinetic
profile as per Lipinski's rule of five (orally active drugs).

Conclusion::

Novel imidazo (2,1-b)-1,3,4 thiadiazole derivatives were strategically designed,
and their binding affinity was meticulously evaluated against the SGLT2 protein. This endeavor
yielded pioneering lead compounds characterized by ultimate binding affinity, coupled with optimal
ADMET properties in adherence to Lipinski's rule of five and favourable noncarcinogenic
profile.
Nanotechnology: Current Developments, Applications and Patents for Non-invasive Topical Cosmetics and Dermatological Therapeutic Delivery
Authors: Kumar Prashant , Mahor Alpana , Chaudhary Varsha , Sharma Shalini
Published: April 2024

:

Nanotechnology exhibits the advancement in the field of invention, by improving the potency of the formulation through the delivery of inventive solutions. To resolve several limita-tions related to conventional formulations, nanotechnology applications are increasing in the cosmetics and dermatological area. Cosmetic and dermatological preparations are considered a thriving branch of the body care arena and their usage has increased dramatically through the past years. Scientists are designing innovative delivery mechanisms and emerging innovations that are presently being utilized in the development of cosmetics. Inventive nanocarriers such as nio-somes, liposomes, microemulsions, nanoemulsions, solid-lipid nanoparticles, nanospheres, and nanostructured (lipid) carriers have substituted the use of traditional drug delivery. These innova-tive nanocarriers have the convenience of better skin permeation, sustained and controlled drug delivery, precise location, higher stability, and greater incorporated capability. Since the usage of cosmetics has increased, the usual delivery system has been substituted by modern delivery ap-proaches. The introduction of newer advancements and novel drug delivery systems make cos-metics and cosmeceuticals more popular with increased market share. This review article on nan-otechnology employed in cosmetics and dermatology emphasizes the numerous innovative nanocarriers designed for cosmetic and dermatologic drug delivery, their negative and positive aspects, and their toxicity.
Crisaborole-Enthused Glycerosomal Gel for an Augmented Skin Permeation
Authors: Singh Ragini , singh Anshu , Srivastava Dipti , Fatima Zeeshan , Prasad Rammani
Published: April 2024

Background:

Crisaborole (CB), a boron-based compound, is the first topical PDE4 inhibitor
to be approved by the US Food and Drug Administration (2016) for the treatment of Atopic
Dermatitis. It is marketed as a 2% ointment (Eucrisa, Pfizer). However, CB is insoluble in water;
therfore, CB glycersomes were formulated to enhance its permeation flux across the skin.

Objective:

We developed a glycerosomal gel of CB and compared its in vitro release and permeation
flux with the 2% conventional ointment

Methods:

Glycerosomes were prepared using thin film hydration method employing CB, soya
phosphatidylcholine, and cholesterol. The formed film was further hydrated employing a mixture of
phosphate buffer pH 7.4 /glycerin solution containing varying percentages (20,30, 40, and 50 %) of
glycerol. The glycerosomes obtained were characterized by their size, polydispersity index (PDI),
and Zeta potential. The entrapment efficiency of the optimized formulation (F 1) was determined.
The in vitro release of F1 was compared with its 2% conventional ointment. F1 was further incorporated
into carbopol 934 P gel. The gel was characterized by pH, viscosity, spreadability, and drug
content. The permeability flux of the glycerosomal gel was compared with its 2% conventional
ointment.

Results:

The optimized CB glycerosomes had a vesicle size of 137.5 ± 50.58 nm, PDI 0.342, and
zeta potential -65.4 ± 6.75 mV. CB glycerosomal gel demonstrated a 2.13-fold enhancement in the
permeation flux.

Conclusion:

It can thereby be concluded that glycerosomes can be an effective delivery system to
enhance the penetration of CB across the skin.
In Vitro Development of Enteric-Coated Tablets of the Probiotic Lactobacillus
fermentum LF-G89: A Possible Approach to Intestinal Colonization
Authors: Spínello Paola , do Nascimento Pamela , da Silveira Verônica Cristina , Staudt Tatiana , Omidian Hamid , Tissiani Ana Caroline , Bertol Charise Dallazem
Published: April 2024

Background:

Probiotics must be able to withstand the demanding environment of the
gastrointestinal system to adhere to the intestinal epithelium, promoting health benefits. The use of
probiotics can prevent or attenuate the effects of dysbiosis that have a deleterious effect on health,
promoting anti-inflammatory, immunomodulatory, and antioxidant effects.

Objective:

The aim of the study was to prepare tablets containing Lactobacillus fermentum LF-G89
coated with 20% Acryl-Eze II® or Opadry® enteric polymers.

Methods:

Tablet dissolution was evaluated under acidic and basic pH conditions, and aliquots of the
dissolution medium were plated to count the Colony-forming Units (CFU). The free probiotic's tolerance
to pH levels of 1.0, 2.0, 3.0, and 4.0, as well as to pepsin, pancreatin, and bile salts, was assessed.

Results:

The probiotic was released from tablets coated after they withstood the pH 1.2 acid stage
for 45 minutes. The release was higher with the Acry-Eze II® polymer in the basic stage. The
amount of CFU of free probiotics at pH 1.0 to 4.0 as well as pepsin reduced over time, indicating
cell death. Conversely, the CFU over time with pancreatin and bile salts increased, demonstrating
the resistance of L. fermentum to these conditions due to hydrolases.

Conclusion:

Both coating polymers were able to withstand the acid step, likely ensuring the release
of the probiotic in the small intestine, promoting colonization. Coating with enteric material is a
simple and effective process to increase the survival of probiotics, offering a promising alternative
to mitigate the negative effects of the dysbiosis process.
Six Sigma az előregyártásban: esettanulmány a betonacél megmunkálásnak fejlesztéséről
Authors: Pap Réka Zsófia , Szűcs Edit
Published: April 2024

Lean process improvements are crucial for enhancing production efficiency. In my research, I examine the application of the DMAIC methodology to develop the MEP facility within the framework of lean Six Sigma. Highlighting the challenges of precast concrete production, my study details how lean management aids in efficient process design and measurement. Introducing lean Six Sigma methodology involves standardizing processes and ensuring their effective development, contributing to the facility's efficiency
Russian-German Economic Relations in the Context of the Deepening Political Confrontation Between the Russian Federation and the European Union
Authors: Kuzmina V. M. , Parkhomchuk M. A.
Published: April 2024

Relevance. Today, Russian-German economic relations, on the one hand, are developing in the context of Russia ‒ EU relations, and on the other hand, between the Russian Federation and Germany, but they are weighed down by the influence of political factors. The traditional areas of economic cooperation received their first cracks due to the introduction of sanctions in 2014, but the “fourth” package of sanctions in March 2022 from the EU, which was successfully joined by the Scholz government, disrupted the world economic ties between countries that had been established for decades.

The purpose is to assess the economic cooperation between Russia and Germany, taking into account the complicated political relations between the EU and the Russian Federation.

Objectives: identify priority areas of cooperation between Russia and Germany at the present stage; highlight the constraining factors of economic relations between countries.

Methods. A discursive analysis of the official statements of the heads of government was applied to study the qualitative and quantitative indicators of cooperation between the Russian Federation and Germany. The secondary statistical data obtained on the basis of the gravity modeling approach are analyzed.

Results. The study showed that one of the most effectively developing industries is the investment of German companies in enterprises of Russian regions. The sanctions of the EU countries had a negative impact on certain high-tech sectors of the Russian economy, but Russian counter-sanctions on meat, milk and dairy products, as well as fruits and vegetables "hit" the consumer in the EU countries and Germany. The forecast of trade and economic relations in connection with the upcoming "fifth" package of EU sanctions against the Russian Federation is difficult.

Conclusions. Germany occupied a significant place in trade, economic and investment cooperation with Russia. At the moment, unfounded accusations of Russia that our country is a “threat” to the European Union continue to be unraveled. Germany actively supports the EU in its course towards the introduction of new sanctions measures against the Russian Federation.
Analysis of the Export Potential of the Branches of the Agro-Industrial Complex of Russia
Authors: Tserenov I. V. , Dzhancharova G. K. , Tsitsige . .
Published: April 2024

Relevance. Russian export of agricultural products by the end of 2020 showed a high potential for growth. Record harvests in some segments of the agricultural industry allowed Russia not only to increase the volume of supplies of agricultural products to the world food markets, but also to actually open new promising markets in Africa, Asia and Europe. State programs to support Russian farmers will maximize the stimulation of production and development of this industry, not only in terms of increasing production volumes, but also in terms of creating rural infrastructure.

The purposeof this article is to assess the prospects for the development of individual sectors of the Russian agro-industrial complex and the possibilities of increasing the volume of export supplies to world food markets.

Objectives. The article set and consistently solved the following tasks: to assess the results of the work of the Russian agro-industrial complex in the context of a pandemic economic development, to assess the volume of agricultural exports to international food markets, to analyze the state program "Export of agro-industrial products".

Methodology. In the process of writing the work, methods of statistical analysis, graphical analysis of data, horizontal and vertical analysis, logical techniques, methods of analogy and generalization were used.

Results. The review of the state and dynamics of the development of Russian agricultural exports made it possible to make a forecast and draw conclusions about the high potential of some branches of the agro-industrial complex for growth and expansion of supplies to the world food markets of Africa, Asia, and Europe.

Conclusions. The program to stimulate the export of agricultural products until 2024 allowed Russia to advance in the ranking of world exports to 20th place at the end of 2020. Further advancement of the position in the rating will depend on the structure of export itself and the increase in the production of the processing industry in it. Forecasts for the growth of export of Russian agro-industrial complex products are quite optimistic and will depend on a number of objective factors.
The Phenomenon of Human State Existence in the Context of Philosophical and Legal Thought of Western European Civilization
Authors: Panishchev A. L.
Published: April 2024

Relevance. This article is devoted to the study of the relationship between human nature and the state as a form of its expression. The relevance of this topic is determined by the fact that since the beginning of the XXI century there has been a tendency for the state as a form and way of being of a person to be squeezed out by transnational corporations. Meanwhile, the nature and essence of a transnational corporation differs from the nature and essence of a State, primarily in an anthropological sense.

Purpose. The purpose of the presented work is to study the process of development of philosophical and legal thought in the direction of analyzing the anthropological meaning of the state and law.

Objectives. The objectives of the article are to analyze the philosophical relationship between anthropological and legal thought at various stages of the development of European civilization: 1) in the era of Antiquity; 2) the Middle Ages; 3) Modern times; 4) Modern times, including modernity.

Methodology. The comparative method, analysis and synthesis served as the methodological basis of this article. At the same time, the analysis of this topic took place in the historical and philosophical plane, which reflected some aspects of the evolution of philosophical and legal thought. The emphasis was placed on Western European philosophy, since a comprehensive analysis of the philosophical understanding of the relationship between man and the state in different cultural traditions is impossible in one article.

Results. The author pays special attention to natural law, emphasizing its direct derivation from human nature. An anthropological crisis can lead to the degeneration of natural law, which will predispose states to disintegration. As a matter of fact, already relative to the time of the turn of the XX-XXI centuries, it is appropriate to state the gap between natural and positive law, which, although smoothed by some measures, for example, the ban on the death penalty, but in general continues to worsen.

Conclusions. State policy should take into account spiritual values, which is a form of the state's concern for itself, since it is impossible to preserve national unity without a developed culture.
Assessment of Development Prospects of Non-Profit Organizations: Foreign and Domestic Practices
Authors: Polozhentseva Yu. S.
Published: April 2024

Relevance. The socially oriented economy of foreign countries and Russia has led to an increase in the role of the non-profit sector in ensuring the effectiveness of supporting the population, primarily in the social sphere. However, the level of development of non-profit organizations (NPOs) largely depends on the existing mechanisms of state support, which they can use in the course of their activities to obtain additional benefits. There is a tendency for NCOs to accumulate in economically developed regions and to reduce their presence in remote or small regions.

Purpose. The purpose of the study is to study the features of the development of NGOs in Russia and abroad, as well as the mechanisms for their support.

Objectives: analyze the key aspects of the development of NGOs in the Russian Federation and in foreign countries; to consider the measures of assistance to NGOs used by foreign partners of the Russian Federation, to identify shortcomings in the existing mechanism for providing support to NGOs in our country, to formulate proposals for changing the tools for providing assistance to the non-profit sector.

Methodology. The study is based on a general scientific approach, including methods of analysis and synthesis, a systematic analysis of domestic and foreign experience in the field of NPOs, and the identification of key aspects of the functioning of NPOs.

Results. The study analyzes the dynamics of growth in the number of NGOs in the Russian Federation and in foreign countries. The impact of NPOs on the development of the Russian economy, in terms of the share of NPOs in the country's GDP, is analyzed. Based on a generalization of the current situation in the field of development of the non-profit sector in the Russian Federation, the key directions for the formation of the “Strategy for the Development of Non-Commercial Organizations in the Russian Federation” are identified.

Conclusions. As part of the study, the degree of development of NGOs in Russia and abroad is considered in detail, the main directions for supporting this sector at various levels are identified, and the importance of the functioning of NGOs in order to develop civil society and the social sphere is emphasized.
Effects of a Planned Web-Based Educational Intervention Based on the Health Belief Model for Patients With Ischemic Stroke in Promoting Secondary Prevention During the COVID-19 Lockdown in China: Quasi-Experimental Study
Authors: Liu Zhuo , Sun Xin , Guo Zhen-Ni , Sun Ye , Yang Yi , Yan Xiuli
Published: April 2024

Background

Some common modified vascular risk factors remain poorly controlled among stroke survivors, and educational programs may help improve these conditions.

Objective

This study aimed to evaluate the effect of a planned web-based educational intervention based on the health belief model (HBM) in promoting secondary prevention among patients with ischemic stroke.

Methods

An evaluation-blinded quasi-experimental trial with a historical control group was conducted. Patients admitted from March to June 2020 were assigned to the historical control group, and patients admitted from July to October 2020 were assigned to the intervention group. The control group received routine health management. The intervention group received 6 additional sessions based on the HBM via Tencent Meeting, an audio and video conferencing application, within 3 months after discharge. Sessions were held every 2 weeks, with each session lasting approximately 40 minutes. These sessions were conducted in small groups, with about 8 to 10 people in each group. The primary outcomes were changes in blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c (HbA1c), and the proportion of patients achieving the treatment target. The secondary outcomes were medication adherence, assessed with the Morisky Medicine Adherence Scale (MMAS), and disability, assessed with the modified Rankin scale.

Results

In total, 315 patients experiencing their first-ever stroke were analyzed. More patients in the intervention group had controlled BP (41.9% vs 28.4%; adjusted odds ratio [aOR] 1.93; P=.01), LDL-C (83.1% vs 67.7%; aOR 2.66; P=.001), and HbA1c (91.9% vs 83.9%; aOR: 3.37; P=.04) levels as well as a significant postintervention decrease in the systolic BP (adjusted β −3.94; P=.02), LDL-C (adjusted β −0.21; P=.008), and HbA1c (adjusted β −0.27; P<.001), compared with control groups. Significant between-group differences were observed in medication adherence (79.4% vs 63.2%; aOR 2.31; P=.002) but not in favorable functional outcomes.

Conclusions

A web-based education program based on the HBM may be more effective than current methods used to educate patients having strokes on optimal vascular risk factors and medication adherence.
Assessing Electronic Health Literacy in Individuals With the Post–COVID-19 Condition Using the German Revised eHealth Literacy Scale: Validation Study
Authors: Marsall Matthias , Dinse Hannah , Schröder Julia , Skoda Eva-Maria , Teufel Martin , Bäuerle Alexander
Published: April 2024

Background

The eHealth Literacy Scale (eHEALS) is a widely used instrument for measuring eHealth literacy (eHL). However, little is known so far about whether the instrument is valid for the assessment of eHL in persons who are affected by the post–COVID-19 condition. This is particularly important as people with the post–COVID-19 condition are frequently affected by false information from the internet.

Objective

The objective of our study was to evaluate the validity and reliability of the German Revised eHealth Literacy Scale (GR-eHEALS) in individuals with the post–COVID-19 condition.

Methods

A cross-sectional study was conducted from January to May 2022. The self-assessment survey consisted of the GR-eHEALS, health status– and internet use–related variables, sociodemographic data, and (post)–COVID-19–related medical data. Confirmatory factor analysis (CFA), correlational analyses, and tests of measurement invariance were deployed.

Results

In total, 330 participants were included in the statistical analyses. CFA revealed that the 2-factor model reached an excellent model fit (comparative fit index=1.00, Tucker–Lewis index=0.99, root mean square error of approximation=0.036, standardized root mean square residual=0.038). Convergent validity was confirmed by significant positive correlations between eHL and knowledge of internet-based health promotion programs, experience in using these programs, and the duration of private internet use. In addition, a significantly negative relationship of eHL with internet anxiety supported convergent validity. Further, significant relationships of eHL with mental health status and internal health locus of control confirmed the criterion validity of the instrument. However, relationships of eHL with physical health status and quality of life could not be confirmed. The 2-factor model was fully measurement invariant regarding gender. Regarding age and educational level, partial measurement invariance was confirmed. The subscales as well as the overall GR-eHEALS reached good-to-excellent reliability (Cronbach α≥.86).

Conclusions

The GR-eHEALS is a reliable and largely valid instrument for assessing eHL in individuals with the post–COVID-19 condition. Measurement invariance regarding gender was fully confirmed and allows the interpretation of group differences. Regarding age and educational level, group differences should be interpreted with caution. Given the high likelihood that individuals with the post–COVID-19 condition will be confronted with misinformation on the Internet, eHL is a core competency that is highly relevant in this context, in both research and clinical practice. Therefore, future research should also explore alternative instruments to capture eHL to overcome shortcomings in the validity of the GR-eHEALS.
Photos Shared on Facebook in the Context of Safe Sleep Recommendations: Content Analysis of Images
Authors: Pretorius Kelly , Kang Sookja , Choi Eunju
Published: April 2024

Background

Sudden unexpected infant death (SUID) remains a leading cause of infant mortality; therefore, understanding parental practices of infant sleep at home is essential. Since social media analyses yield invaluable patient perspectives, understanding sleep practices in the context of safe sleep recommendations via a Facebook mothers’ group is instrumental for policy makers, health care providers, and researchers.

Objective

This study aimed to identify photos shared by mothers discussing SUID and safe sleep online and assess their consistency with infant sleep guidelines per the American Academy of Pediatrics (AAP). We hypothesized the photos would not be consistent with guidelines based on prior research and increasing rates of accidental suffocation and strangulation in bed.

Methods

Data were extracted from a Facebook mothers’ group in May 2019. After trialing various search terms, searching for the term “SIDS” on the selected Facebook group resulted in the most relevant discussions on SUID and safe sleep. The resulting data, including 20 posts and 912 comments among 512 mothers, were extracted and underwent qualitative descriptive content analysis. In completing the extraction and subsequent analysis, 24 shared personal photos were identified among the discussions. Of the photos, 14 pertained to the infant sleep environment. Photos of the infant sleep environment were then assessed for consistency with safe sleep guidelines per the AAP standards by 2 separate reviewers.

Results

Of the shared photos relating to the infant sleep environment, 86% (12/14) were not consistent with AAP safe sleep guidelines. Specific inconsistencies included prone sleeping, foreign objects in the sleeping environment, and use of infant sleeping devices. Use of infant monitoring devices was also identified.

Conclusions

This study is unique because the photos originated from the home setting, were in the context of SUID and safe sleep, and were obtained without researcher interference. Despite study limitations, the commonality of prone sleeping, foreign objects, and the use of both infant sleep and monitoring devices (ie, overall inconsistency regarding AAP safe sleep guidelines) sets the stage for future investigation regarding parental barriers to practicing safe infant sleep and has implications for policy makers, clinicians, and researchers.
Study on English Localization Translation of Domestic Games—Taking the Opera “The Divine Damsel of Devastation” in Genshin Impact as an Example
Authors: Ye Huining
Published: April 2024

In recent years, the demand for game enterprises to explore overseas markets has been growing. Not only have more high-quality foreign games been imported into China, but Chinese games have also become an important part of Chinese culture “going out” and “telling good Chinese stories”. This paper takes the global high popularity game Genshin Impact as an example, and combines the Skopos theory to update the research on game localization from the perspective of Chinese-English translation, and analyzes the application of translation and creation in the process of localization translation of drama.
A Comparative Study on Sustainable Jamdani Saree Manufactured with Sustainable Vegetable Dyes and Available Jamdani Saree Manufactured with Available Dyes
Authors: Chowdhury Mohammed Rubaiyat , Khan Ayub Nabi
Published: April 2024

Jamdani is a UNESCO heritage. The tradition of Jamdani is very old are basically made of hundred percent cotton Jamdani yarn. Now a days Jamdani saree is manufactured with silk filament polyester filament along with 100% cotton yarn. The main manufacturing area of Jamdani saree is at Narayanganj. The Jamdani saree is usually manufactured with different dyes. In this project a Jamdani saree which was already manufactured and a Jamdani saree which was manufacture with 100% cotton yarn and sustainable vegetable dye (Yeliona AHLS-31) were observed. It was found that Jamdani saree which was already manufactured had presence of some banned dyes and the saree made with sustainable vegetable dyes did not contain any banned amines. The manufactures use the banned dyes possibly for the cheap price but the long-time effect of these dyes are hazardous because it causes diseases like skin diseases, lung disease, rash on the skin, etc.
Las probanzas de eclesiásticos y el desarrollo de la Iglesia Secular en Yucatán
Authors: Solís Robleda Gabriela
Published: April 2024

Este artículo aborda el análisis del papel que jugaron los eclesiásticos en su búsqueda de mercedes del rey como recompensa de sus servicios, expuestos en las probanzas que realizaron. La esperanza de eventualmente recibir la merced alentó la realización de actividades necesarias para el buen funcionamiento de la Iglesia secular. Las mercedes que pretendían se centraron en la concesión de alguna prebenda u oficio y en la administración de un curato, especialmente de indios. En el caso del obispado yucateco, la búsqueda de estas mercedes adquirió mayor relevancia por el modelo señorial y rentista que privó en la colonización, sobre todo en la primera centuria del dominio hispano a la que corresponden las probanzas que en este artículo se presentan. Se plantean también las semejanzas y diferencias existentes entre las probanzas eclesiásticas y las que hicieron los seglares, así como la pretensión del clero criollo de ser preferido en las concesiones.
La participación y la apropiación del espacio público como fundamentos del derecho a la ciudad: dos estudios de caso al sur de Mérida, Yucatán
Authors: Anduze Rivero Víctor René
Published: April 2024

A lo largo del presente artículo examino dos importantes festividades celebradas al sur de Mérida, Yucatán, con el objetivo de analizar los procesos de participación y de apropiación del espacio público urbano, en el contexto neoliberal de nuestros días. En Mérida, el crecimiento exponencial de la mancha urbana y la tendencia general hacia la creación de zonas de infraestructuras segregativas nos obligan a plantearnos diversos cuestionamientos. ¿Qué valor asignamos a los lugares cuya posesión, más allá de cualquier marco legal, no es individual sino colectiva? ¿Cómo utilizamos esta clase de espacios? ¿Qué procesos nos acercan o alejan de los espacios que, de acuerdo con especialistas como Borja y Muxó o incluso Lefevbre, son el pilar de toda ciudad? A lo largo de este artículo pretendo elucidar algunas de estas interrogantes, a través del estudio de las dinámicas socioespaciales en que se fundamenta el denominado derecho a la ciudad.
Turismo e identidad maya: ser joven guerrero en el siglo XXI
Authors: Rodriguez Martínez Yassir , Jouault Samuel
Published: April 2024

En este artículo analizamos cómo los jóvenes de una comunidad maya del estado de Yucatán se insertan en la actividad turística mediante la representación de su identidad étnica. Estaescenificación se vincula con el avance del turismo en la península yucateca, lo que ha implicado un proceso continuo de turistificación de nuevos territorios. En la representación de lo que implica ser maya influyen una serie de agentes externos que promueven una etnicidad vinculada a lo exótico y a lo prístino. En definitiva, todo el proceso figurativo de identidad genera que los jóvenes mayas deban adecuarse a las transformaciones del ámbito rural y a la constitución de nuevos nichos turísticos que responden al proceso de globalización neoliberal.
Insights on MDR Mechanism of Pseudomonas aeruginosa with Emphasis on Diabetic Foot Ulcer in the Indian Subcontinent
Authors: Chatterjee Debolina , Sivashanmugam Karthikeyan
Published: April 2024

Diabetic foot ulcers (DFU) in patients with uncontrolled diabetes mellitus are considered a global public health menace that is highly associated with morbidity and mortality. Pathogenic microorganisms entrenched deep into diabetic foot wounds are the causative agents for delayed healing and escalation of diabetic foot wound severity. Pseudomonas aeruginosa is a common opportunistic pathogen associated with several nosocomial infections, cystic fibrosis, and one of the most critical pathogens often isolated from acute and chronic diabetic foot ulcers. The organism can exhibit resistance to a wide range of antibiotics like ciprofloxacin, cefotaxime, and meropenem, thereby causing severe damage to the host tissues, followed by amputation of the affected foot region. Due to their ability to synthesize biofilms, the wound becomes more chronic and incurable, posing a serious threat to immunocompromised diabetic patients. This review highlights on the insights of pathophysiology and microbiological profile of Diabetic foot ulcers, the resistance mechanisms, and the therapeutics available for dealing with drug-resistant Pseudomonas, which could help clinicians in treating DFUs.
Smart Driver Assistance Using Augmented Reality
Authors: Selvakumar Dr. J.
Published: April 2024

Abstract: Augmented Reality (AR) technology enables users to monitor the real world through augmented glasses. The objective of this work is real-time monitoring of the instant location of vehicles, contributing to smart driver assistance. Through this effort, there is a possibility to prevent accidents by displaying real-time data on the Liquid Crystal Display (LCD) Unit via the Augmented glasses. Hence, this endeavor is beneficial for protecting the lives of the drivers as well as the vehicles.
Agri Cart
Authors: Moorthi Dr. M.
Published: April 2024

Abstract: "AGRI CART" is a revolutionary platform designed to modernize agricultural practices, connecting farmers directly with consumers through an online marketplace. This innovative system eliminates middlemen, empowering farmers to sell their produce at fair prices while enabling consumers to access fresh, locally sourced goods. Through AGRI CART, farmers can showcase their products, manage inventory, and set competitive prices, enhancing their profitability and sustainability. Consumers benefit from a diverse range of high-quality, farm-fresh produce delivered conveniently to their doorstep. The platform also fosters transparency, allowing consumers to trace the origin of their food and learn about the farmers who cultivate it. AGRI CART prioritizes environmental sustainability by promoting organic farming practices and reducing food waste. With user-friendly interfaces and secure payment options, the platform ensures a seamless experience for both farmers and consumers. Furthermore, AGRI CART supports rural development by creating opportunities for small-scale farmers to reach broader markets and improve their livelihoods. Through its mobile application, AGRI CART facilitates real-time communication between farmers and consumers, fostering community engagement and trust. By bridging the gap between producers and consumers, AGRI CART revolutionizes the agricultural supply chain, promoting fairness, transparency, and sustainability in food production and distribution.
THE WEAR RESISTANCE OF CYLINDER LINERS RESTORED BY CERAMIC COATING
Authors:   Federal Scientific Agroengineering Center VIM, Moscow, Russian Federation, DENISOV V.A. , POPOV N.A. ,   Federal Scientific Agroengineering Center VIM, Moscow, Russian Federation
Published: April 2024

The results of the study of the workability and wear resistance of the combined coating of the restored cylinder liners obtained by applying a layer of aluminum powder to the cast-iron base by cold gas-dynamic spraying with subsequent treatment by microarc oxidation were presented. (Research purpose) The research purpose is a comparative analysis of the tribotechnical properties of the conjugations "sleeve coated with cold gas-dynamic spraying and treatment with microarc oxidation-counter-sample 100Cr6" and "sleeve (SH25 in the delivery state)-counter-sample 100Cr6" (reference pairing). (Materials and methods) Conducted a study of the workability of materials of the reference and reconstructed conjugations according to RD 50-662-88 "Guidelines. Methods of experimental evaluation of frictional compatibility of materials of friction conjugations". Comparative bench tests were performed on the wear resistance of the reference and restored conjugates according to GOST 23.224-86 "Ensuring the wear resistance of products. Methods for assessing the wear resistance of restored parts". (Results and discussion) The optimal modes of long-term operation and the limits of the interface operability were determined during the stepwise loading of the reference and restored tribo-couplings. The run-in coefficient and the wear factor of the couplings were calculated. It was found that the restored coupling "sleeve coated with cold gas-dynamic spraying and microarc oxidation treatment-counter-sample 100Cr6" has similar run-in rates with the reference coupling, and its wear resistance exceeds the wear resistance of the reference coupling by more than two times. (Conclusions) High indicators of workability and wear resistance of the restored interface "sleeve coated with cold gas-dynamic spraying and microarc oxidation treatment-counter-sample 100Cr6" in comparison with the reference sleeve (from SCH25 in the state of delivery) provide an increase in its durability and indicate the expediency of using the combined method in the restoration of cylinder liners.
CONTRIBUTION OF ACADEMICIAN OF VASKHNIL A.I. SELIVANOVA IN THE TRAINING OF SCIENTIFIC, PEDAGOGICAL AND AGRICULTURAL ENGINEERING PERSONNEL IN RUSSIA
Authors:   Russian State Agrarian University - Moscow Agricultural Academy, Moscow, Russian Federation, EROKHIN M.N. , SKOROKHODOV D.M. ,   Russian State Agrarian University - Moscow Agricultural Academy, Moscow, Russian Federation
Published: April 2024

The development of engineering education in Russia plays an important role in the creation of future technologies, the development of new inventions. (Research purpose) The research purpose is forming a patriotic attitude to engineering education in Russia on the example of the activities of a prominent scientist in the field of mechanization and electrification of agriculture, Doctor of Technical Sciences, Professor, academician of the VASHNIL Aleksandr Ivanovich Selivanov. (Materials and methods) The analysis of literary sources was carried out by applying the historical and analytical method. Modern and historical literary sources, conference materials, scientific manuscripts, military-historical materials, original scientific works of A.I. Selivanov were used as materials. (Results and discussion) They outlined the life and creative path of A.I. Selivanov. After graduating from the Faculty of Industrial Agriculture of the Leningrad Polytechnic Institute, A.I. Selivanov worked his way up from an engineer, head of a laboratory, to deputy director for scientific work of VIM, GOSNITI, Siberian Research Institute of Mechanization and Electrification of Agriculture. (Conclusions) A significant cycle of his work is aimed at developing maintenance and repair systems for machines and the rational organization of the repair base. A.I. Selivanov is the founder of the theory of aging of machines, co-author of the textbook "Theoretical foundations of repair and reliability of agricultural machinery." Under his leadership and with his direct participation, a standard tractor and combine repair technology was developed, which served for many years as the main technical document for all repair enterprises. A.I. Selivanov made a huge contribution to the training of scientific, pedagogical and agroengineering personnel in Russia. His diligence, courage, bravery, heroism, perseverance and many other qualities that are necessary for our younger generation serve as a real example for many people.
CONTINUITY OF V.P. GORYACHKIN'S TEACHING IN THE WORKS OF SCIENTIFIC SCHOOLS OF THE SOUTHERN URALS
Authors:   Chelyabinsk State Industrial and Humanitarian College named after A.V. Yakovlev, Chelyabinsk, Russian Federation, GODLEVSKAYA E.V.
Published: April 2024

The paper summarizes the factual material revealing the contribution of scientists of the agroengineering school of the Southern Urals to the development of V.P. Goryachkin's scientific ideas. The Chelyabinsk Institute of Mechanization and Electrification of Agriculture, established in 1930, became the center for the development of such scientific areas as the study of the dynamics of mobile agricultural units, the development of engine theory, the improvement of tractor design, the development of a differential method for threshing grain crops, the intensification and automation of grain separation processes, the creation of scientific foundations of technical service and the theory of restoration of agricultural machinery. (Research purpose) The research purpose is systematization of historical and scientific materials in the field of development of agroengineering scientific schools of the Southern Urals; showing the continuity of V.P. Goryachkin's teachings in the works of the considered scientific schools. (Materials and methods) Found out that the theoretical and practical results of scientific developments of the Lyubimov school were greatly influenced by numerous field tests in collective farms and state farms of the Southern Urals, as well as the use of computer-aided design systems for computing. The influence of the development of tractors of the Chelyabinsk Tractor Plant on the scientific research of E.M. Kharitonchik, I.E. Ulman was described. The links between branch scientific institutes and the Chelyabinsk Institute of Mechanization and Electrification of Agriculture were highlighted. (Results and discussion) We systematized the scientific achievements of the teaching staff of the Chelyabinsk Institute of Mechanization and Electrification of Agriculture from 1930 to 2023. (Conclusions) Scientists of scientific schools of the Southern Urals fully used all the resources available in the region and beyond: close communication within the branch scientific community (VIM, GOSNITI, NATI), close work with advanced industrial and agricultural enterprises for the development of agroengineering science and education and the introduction of the results into production.
WEAR PROCESS IN CRANKSHAFT JOURNALS RESTORED BY INSTALLING STEEL SEMI-RING LININGS
Authors:   Vologda State Dairy Farming Academy named after N.V. Vereshchagin, Vologda, Russian Federation, BERDENNIKOV E.A.
Published: April 2024

Installation of steel semi-ring linings on the crankshaft journals is a rational technological solution that can significantly reduce the thermal deformation of the crankshaft in the process of its restoration compared to building-up welding or tape welding. (Research purpose) The research purpose is studying the wear rate in crankshaft journals restored by installing steel semi-ring linings. (Materials and methods) The wear rate in the restored crankshaft journals has been theoretically calculated using I.V. Kragelsky’s method. The diesel engine crankshaft in a Volkswagen Transporter car, which was in operation, has been taken as an experimental sample. The semi-ring linings have been installed on the crankshaft journals by butt welding to each other. The main criterion for the experimental evaluation is the wear rate of the restored journals under real operating conditions. When measuring wear, both the profilogram method and the micrometric method have been used for measuring the diameters of the crankshaft journals before and after a certain car run. (Results and discussion) The values of the main journal wear during real car run are comparable to the theoretical calculation results. The wear degree of the connecting rod journals exceeds the wear of the main ones, which can be explained by absence of heat treatment of the half rings in the connecting rod journals when restoring the shaft. The actual values of ellipsity as well as taper rates of the journals are within the acceptable values. The wear values obtained by measuring roughness before and after the test period are comparable to those obtained by micrometric measurement. (Conclusions) The wear rate of both connecting rod and main crankshaft journals is comparable to the values determined by theoretical calculation, which makes it possible to conclude that the experimental research has a positive result. The wear rates determined both experimentally and theoretically are within the limits established by earlier studies in the field of tribology, which indicates the reliability of the experimental results. Thus, the applicability of the method of installing steel semi-ring linings when restoring crankshafts of automotive engines has been confirmed.
HE USE OF SECONDARY POWDER MATERIALS FOR THE RESTORATION OF BRONZE PARTS OF HYDRAULIC MACHINES
Authors:   Federal Scientific Agroengineering Center VIM, Moscow, Russian Federation, ROMANOV I.V.
Published: April 2024

During the operation of agricultural machinery, machine parts and their connections lose their operability, which requires their replacement. The cost of restoration is 50-60 percent of the cost of a new part. The presence of non-ferrous metal and alloy parts in the equipment, and in particular bronze, makes the issue of restoration even more urgent due to the high cost of such parts. Methods using powder materials are particularly successful in restoring worn parts. It is characteristic that in order to reduce the cost of such technologies, it is possible to resort to recycling of metal waste and obtain powder by electroerosive dispersion without special economic costs. (Research purpose) The research purpose is studying the restoration of bronze parts of hydraulic machines with secondary powder materials and analyzing the tribotechnical indicators of the coatings obtained. (Materials and methods) The following equipment was used in the work: an Elitron-52B pulse generator, a scanning electron microscope, a spark plasma sintering unit, an electric spark alloying unit, an X-ray fluorescence spectrometer, a metallographic microscope, a tribometer, analytical scales, a drying cabinet, a set of sieves. (Results and discussion) Electrodes were made from bronze powder obtained by the method of electroerosive dispersion. Using electric spark alloying, samples with coatings from a standard and a new obtained electrode were created. The tribotechnical properties of these coatings were compared. Metallographic and chemical analyses were performed. (Conclusions) The coatings obtained with the new electrode showed the best tribotechnical characteristics in dry friction. At boundary friction, their performance was worse, which may be due to an incorrect choice of lubrication, modes of electric spark alloying and a violation of the technology for obtaining the electrode itself. In general, the use of secondary powder materials for the restoration of bronze parts is relevant.