bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical features and serum cytokine profiles of elderly-onset adult-onset Still’s disease: comparison with young and middle-aged-onset cases
Authors: Yagishita Mizuki , Tsuboi Hiroto , Kuroda Yuki , Sawabe Tomoki , Kawashima Akira , Kawashima Fumina , Uematsu Nana , Sato Ryota , Nishiyama Taihei , Terasaki Mayu , Toko Hirofumi , Honda Fumika , Ohyama Ayako , Abe Saori , Kitada Ayako , Miki Haruka , Hagiwara Shinya , Kondo Yuya , Sumida Takayuki , Matsumoto Isao
Published: June 2022

Recent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged <65 years) and the elderly-onset group (aged ≥65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD.
Logic model for opioid analgesics in chronic non-malignant pain management, an in-depth qualitative methods study
Authors: Iqbal Ayesha , Knaggs Roger David , Anderson Claire , Toh Li Shean
Published: June 2022

BackgroundOpioids are commonly used for the management of chronic non-malignant pain in Pakistan; but there is a lack of literature around precursors or motivators in the use of opioids.AimThis study holistically explored factors contributing towards the unsafe use of opioids and identifies strategies to overcome them.MethodThis study used exploratory qualitative methods using interviews, focus groups and non-participant observational case studies. Interviews and focus groups were carried out face to face as well as virtually whereas non-participant observations were conducted in community pharmacies in Islamabad and Khyber Pukhtoon Khuwa province, Pakistan. Data was collected from 4 stakeholder groups; pharmacy policy makers (n = 11), people with chronic non-malignant pain (n = 14), doctors (n = 31) and community pharmacists (n = 36) by purposive critical case sampling method. Data were inductively analysed using reflexive thematic analysis and then deductively mapped to a social ecological framework. Non-participant observations were analysed using a cross case synthesis using explanation building technique. Data from all 3 methods was triangulated to develop a logic model.ResultsIdentified factors at macro (regulation), meso (social perceptions of pain and opioids) and micro levels (uncontrolled pain, self-medication, health literacy) are presented holistically were used to develop a logic model for the prevention and mitigation of factors currently causing unsafe use of opioids.ConclusionsPolicymakers need to contextualise factors and carefully plan community pharmacy interventions within healthcare system to overcome challenges and barriers on various social ecological levels to promote optimised use of opioids in the management of chronic non-malignant pain in Pakistan.
Comprehensive Analysis of Pyroptosis-related Genes for the Prognosis of Esophageal Cancer
Authors: Zhou Xiaoying , Li Wenjie , Xia Peichen , Chen Han , Su Xin , Li Xinyan , Jiang Xingzhou , Zhang Guoxin
Published: June 2022

Esophageal cancer (EC), known for its high malignancy and difficulty in treatment, has seen a significant increase in incidence in recent years. Studies on prognosis of EC are extremely urgent to provide personalized medicine which will benefit more patients individually. Pyroptosis, an inflammatory form of programmed cell death triggered by caspase-1/4/5/11 which is activated by some inflammasomes has been connected to cancer in recent studies. However, the association between pyroptosis-related genes and esophageal cancer has not been elucidated, and their vital role in the development and prognosis of esophageal cancer needs further research. In this study, we obtained 290 samples from both TCGA and GEO database. Firstly, we screened 32 pyroptosis-related regulators that were differentially expressed in normal esophageal and cancer tissues. Then, univariate Cox regression analysis and LASSO analysis were applied and we obtained 8 key pyroptosis-related genes to construct the risk model for predicting the prognosis of EC patients. We verified the expression levels of these eight genes in cells in vitro. Based on the risk score and other clinical features, a nomogram was plotted. Through two clustering analyses, we elaborated the enrichment of pyroptosis-related genes in terms of pathways, signaling, immune response, and clinical characteristics. Finally, we calculated the pyroptosis score which could also predict the prognosis of EC and had strong relationship with clinical features. In conclusion, pyroptosis-related genes are intimately related with EC and can be used to predict the prognosis of EC, which may also provide novel therapeutic schedule for EC patients.
Urban Greenness and Pricing Premium on Residential Properties
Authors: Wahid Abdul , Mumtaz Muhammad Zubair , Kowalewski Oskar
Published: June 2022

This study examines how the urban climate affects the price, and urban greenness causes the pricing premium. To explore the greenness aspects, we construct a composite pollution index for each property traded in twin cities—Islamabad and Rawalpindi—based on the area traded properties' water, air, noise, and soil pollution. To examine the pricing efficiency of these properties, we categorize our sample into green and non-green properties using machine learning and measure the impact of environmental factors on their price. Along with other property characteristics, we observe that air pollution, noise pollution, and water pollution emerge as vital factors that define the prices of properties. Similarly, investors are willing to pay higher prices for green residential properties with a lower pollution index. The study findings are helpful for investors, housing society managers and developers, as they show that greenness pays back.JEL Codes: R20, R30, R31
Comprehensive treatment of a rare primary malignant pericardial mesothelioma: A case report and literature review
Authors: Liu Chunyu , Zhao Bin , Cheng Weiwei , Ma Dongliang , Wei Xing , Zhang Shunye
Published: June 2022

Background: Primary malignant pericardial mesothelioma (PMPM) is an extremely rare aggressive malignancy with nonspecific symptoms; thus, cases of PMPM are usually found incidentally. Despite treatment, it is considered extremely fatal.Case presentation: We encountered an asymptomatic 64-year-old woman diagnosed with PMPM by positron emission tomography/computed tomography (PET/CT). After 22 months of supportive treatment and chemotherapy, she presented to our facility with progressive dyspnoea. Surgery was performed. Excision biopsy showed thickening pericardium and many poorly circumscribed masses, and cut sections showed friable grey–white tissue with areas of necrosis. Pathological examination confirmed epithelium-like malignant mesothelioma. The patient was continuously treated with a previously prescribed chemotherapy regimen. The patient did not exhibit dyspnoea recurrence, and PET/CT showed no progression 7 months postoperatively.Conclusion: Comprehensive treatment, including chemotherapy, supportive treatment, and timely surgery, is effective for unresectable PMPM. When patients present with symptoms caused by PMPM that are not relieved by medication, we recommend prioritising urgent surgery.
Using LabVIEW to evaluate Hydrogen fuel cell-based systematic vehicular application to promote the green economy
Authors: Farooq Aqeel
Published: June 2022

The authors have requested that this preprint be removed from Research Square.
Preservation of endocrine function after Ommaya reservoir insertion in children with cystic craniopharyngioma
Authors: Lohkamp Laura-Nanna , Kulkarni Abhaya V. , Drake James M. , Rutka James T. , Dirks Peter B. , Taylor Michael , Ibrahim George M. , Hamilton Jill , Bartels Ute K.
Published: June 2022

Introduction: Children with craniopharyngiomas (CP) can experience significant morbidities caused by extensive surgery and/or radiation. Ommaya reservoir insertion (ORI) into cystic CP represents a minimally invasive approach allowing immediate decompression and aims to avoid additional injuries. The purpose of this study was to determine the surgical outcome and relevance of upfront ORI (+/- intracystic treatment) for preservation of endocrine function. Methods: We performed a retrospective chart review of children with CP treated at the Hospital for Sick Children between 01/01/2000 and 15/01/2020. Endocrine function was reviewed at the time of initial surgery and throughout follow-up. New endocrinological deficits related to the index procedure were defined as immediate failure (IF), whereas postoperative duration of endocrinological stability was defined as event-free survival. The rate of IF and EFS were compared between the treatment groups. Results: Seventy-nine patients were included and had a median age of 8.3 years (range 2.1–18.0 years); 31 were males. Fifty-three patients with upfront surgical treatment, including 29 ORI and 24 gross total or partial resections had sufficient endocrinological follow up data. Endocrine dysfunction occurring immediately after the index procedure was observed in 15 patients (62.5%) in the resection group compared to 2 patients (6.8%) in the ORI group, odds ratio: 0.05 (CI: 0.01–0.26, p < 0.0001). Along those with immediate deficits, mean EFS after ORI was 19.4 months (CI: 11.6–34.2), compared to 13.4 months (CI:10.6-NA) after surgical resection. Conclusions: Endocrine function was preserved in patients with upfront ORI (+/- intracystic treatment), which was confirmed as a minimally invasive procedure with an overall low morbidity profile.
Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Côte d’Ivoire
Authors: Zahouli Julien Z. B. , Dibo Jean-Denis , Diakaridia Fofana , Yao Laurence , Souza Sarah D. , Horstmann Sebastian , Koudou Benjamin G.
Published: June 2022

Background: Space spraying of insecticides is still an important mean of controlling Aedes and Culex mosquitoes and arboviral diseases. This study evaluated the space spray efficacy of Fludora Co-Max EW (a combination of flupyradifurone and transfluthrin, with Film Forming Aqueous Spray Technology (FFAST)) against wild, insecticide-resistant Aedes aegypti and Culex quinquefasciatus populations from Abidjan, Côte d’Ivoire, against K-Othrine EC (deltamethrin-only product), through small-scale field trials. Methods: Wild Ae. aegypti and Cx. quinquefasciatus mosquito larvae were collected in Abidjan, Côte d’Ivoire from August to December 2020. Mosquito larvae were reared until adult stage. Emerged adult females were tested against Fludora Co-Max EW and K-Othrine EC using ultra-low volume cold fogging (ULV) and thermal fogging (TF) both outdoors and indoors in Agboville, Côte d’Ivoire. Cages containing 20 mosquitoes each were placed at 10, 25, 50, 75 and 100 m from the spraying line for outdoor spraying, and at ceiling, mid-height and floor levels for indoor house spraying. Knockdown and mortality were recorded at each checkpoint and compared by treatments.Results: Overall, Fludora Co-Max EW induced significantly higher knockdown and mortality effects in the wild insecticide-resistant Ae. aegypti and Cx. quinquefasciatus compared with K-Othrine EC. With both species, Fludora Co-Max EW mortality rates were above 80% (up to 100%) for outdoor ULV spray at each distance checkpoint (i.e. 10 to 100 m), and 100% for indoor ULV and TF sprays at all level checkpoints (i.e. ceiling, mid-height and floor). K-Othrine EC induced high mortality indoors (97.9-100%), whereas outdoor mortality rapidly declined in Ae. aegypti from 96.7% to 36.7% with ULV, and 85.0% to 38.3% with TF, from 10 to 100 m. For outdoor Fludora Co-Max EW spray, ULV showed both higher knockdown and killing performance Ae. aegypti and Cx. quinquefasciatus compared with TF. Fludora Co-Max EW performed better against Cx. quinquefasciatus compared with Ae. aegypti.Conclusions: Fludora Co-Max EW induced high mortality and knockdown effects against wild insecticide-resistant Ae. aegypti and Cx. quinquefasciatus Abidjan strains and performed better than K-Othrine EC. The presence of flupyradifurone and transfluthrin (with new and independent modes of action) and FFAST technology in the current Fludora Co-Max EW formulation appears to have broadened its killing capacity. Fludora Co-Max EW is thus an effective adulticide and may be a useful tool for Aedes and Culex mosquito and arbovirus control in endemic areas.
Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection
Authors: Reynard Olivier , Gonzalez Claudia , Dumont Claire , Iampietro Mathieu , Ferren Marion , Guellec Sandrine Le , Lajoie Laurie , Mathieu Cyrille , Carpentier Gabrielle , Roseau Georges , Bovier Francesca , Zhu Yun , Pennec Deborah Le , Montharu Jerome , Addetia Amin , Greninger Alexander , Alabi Christopher , Moscona Anne , Vecellio Laurent , Porotto Matteo , Horvat Branka
Published: June 2022

Measles is the most contagious airborne viral infection and the leading cause of child death among vaccine-preventable diseases. We show here that aerosolized lipopeptide fusion inhibitors, derived from heptad-repeat regions of the measles virus (MeV) fusion protein, block respiratory MeV infection in a non-human primate model, the cynomolgus macaque. We used a custom-designed mesh nebulizer to ensure efficient aerosol delivery of peptides to the respiratory tract and demonstrated the absence of adverse effects and lung pathology in macaques. The nebulized peptide efficiently prevented MeV infection, resulting in the complete absence of MeV RNA, MeV-infected cells, and MeV-specific humoral responses in treated animals. This strategy provides an additional shield which complements vaccination to fight against respiratory infection, presenting a proof-of-concept for the aerosol delivery of fusion inhibitory peptides to protect against measles and other airborne viruses, including SARS-CoV-2, in case of high-risk exposure, that can be readily translated to human trials.
FPGA Implementation of DOA Estimation Method Based on Polarization Sensitive Array
Authors: Liu Lutao , Cao Ying , Guo Muran
Published: June 2022

In this paper, the Field Programmable Gate Arrays (FPGAs) implementation of multiple signal classification (MUSIC) algorithm based on polarization sensitive array is discussed for the first time. Directly embedding the conventional complex-valued MUSIC in FPGA will waste a lot of hardware resources and involve high computational burden. Thus, we propose a real-valued direction of arrival (DOA) estimation method based on polarization sensitive arrays for FPGA implementation in this paper. The proposed method introduces a linear transformation on the received signal, thus simplifying the subsequent calculations of the polarization MUSIC algorithm. In addition, the whole FPGA implementation scheme using the proposed real-valued MUSIC based on distributed polarization-sensitive arrays is also developed in this paper. The proposed scheme releases the computational burden via exploiting the parallel calculation of the covariance matrix, the parallel Jacobi algorithm of multiple cleaning of eigenvalue decomposition (EVD), the multi-level spectral peak search method, and the pipelining of each module. The multi-level and multi-group cleaning in the EVD module reuse the resources occupied by a group of cleaning, and the spectral peaks are serially searched in the peak search module. Consequently, compared with the complex-valued MUSIC, the hardware resource consumption and computation burden is dramatically reduced in the proposed scheme.
Prevalence, correlations, and impact of sleep disturbance in Chinese patients with primary pituitary adenomas
Authors: Zhang Xiaomei , Li Yanqing , Gu Yan , Qin Yi , Dong Chen
Published: June 2022

Purpose
Sleep disorders are prevalent among patients with pituitary adenoma (PA) and may lead to disease aggravation and decreased health-related quality of life (HRQoL). Relatively scarce information is available on sleep disturbance in primary PA patients in China. Therefore, this study aims to evaluate the sleeping quality in Chinese primary PA patients and the prevalence, correlates, and impact of sleep disturbance.
Methods
A total of 203 primary PA patients were involved in this cross-sectional study. A series of questionnaires (Pittsburgh Sleep Quality Index (PSQI), MD Anderson Symptom Inventory Brain Tumor for clinical manifestations (MDASI-BT), Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20), and the Short Form 36 health survey (SF-36)) were applied. Independent samples t tests, Mann-Whitney U test, Chi-square analysis, and logistic regression were used to analyze these data.
Results
Our results found that the prevalence of sleep disturbance was 47.8% in primary PA patients. The significant differences were found on the place of residence, alcohol use, depression, anxiety, fatigue, somatic symptom scores and counts, among poor sleepers and good sleepers. Binary logistic regression indicated that fatigue and alcohol use were independently associated with sleep disturbance of primary PA patients. Meanwhile, HRQL of sleep poor patients is clearly lower than those with good sleep.
Conclusions
Primary PA patients in China suffered from sleep disturbance. The results emphasize the importance of fatigue and alcohol use in the sleep disturbance of PA patients. Medical personnel should pay more attention to PA patients with sleep disturbance before the initial diagnosis and preparation for surgery in order to take effective measures early to improve sleep disturbance, with the ultimate goal to improve their QoL.
Coexistence of primary malignancies from liver and ovarian: A rare case report
Authors: Tan Shunde , Chen Jianfei , Fan Jun , Peng Yisheng , Zhu Gang , Li Xinkai , Yang Xiaoli , Li Bo
Published: June 2022

A 54-year-old female presented to the outpatient with a chief complaint of abdominal distention. Abdominal contrast-enhanced CT scan demonstrated mucinous ovarian cancer (MOC) complicating liver metastases. However, the tumor was diagnosed with primary intrahepatic cholangiocarcinoma (PICC)on contrast-enhanced ultrasound (CEUS) and PET-CT. And the two ovarian masses were tended to be mucinous ovarian cystadenomas, while borderline and malignant mucinous tumors could not be excluded completely. Biopsies of the liver was performed due to the patient request. The liver mass was primary intrahepatic cholangiocarcinoma. Her lesions in liver and ovary were resected. The masses of ovarian were mucinous ovarian cystadenoma by intraoperative frozen section analysis. Unfortunately, however, postoperative pathological examinations and immunohistochemistry (IHC) diagnosed as ovarian mucinous cystadenoma malignant change. This was an unusual and rare case of the coexistence of multiple tumors in liver and ovary. The rare pluralism diseases should be noted, when facing complex patients who just a single condition cannot fully reflect clinical findings.
Identification of novel enhancer RNA biomarkers and corresponding prognostic signatures of hepatocellular carcinoma
Authors: Chen Peng , Qi Debin , Sun Keyan , Song Shaohua , Li Tao
Published: June 2022

Background
Researchers now pique an interest in pursuing investigations of enhancer RNAs (eRNAs ). Their roles in the tumorigenesis regulatory mechanism of hepatocellular carcinoma (HCC) remain to be elucidated. Further investigation on eRNAs may shed light on putative prognosis biomarkers and therapeutic targets, which may benefit for early diagnosis of HCC.
Methods
RNA-Seq data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Data were analyzed using R software. Prognosis-related eRNAs were identified, and the target genes of eRNAs were predicted based on the correlation level. We performed enrichment analyses and constructed prognostic model using selected eRNA and target genes, then systematically evaluated prognostic effect. The selected target genes were also analyzed in pan-cancer.
Results
ERNA expression levels were summarized, and 125 prognosis-related eRNAs were identified. Among them, 43 eRNAs were identified because of having putative downstream target genes. After searching literatures, 15 eRNA and target gene pairs were selected for the association with HCC tumorigenesis process or biological behaviors. We chose AL137803.1 for further investigation. The differentially expressed target genes of AL137803.1 in HCC were determined. We performed enrichment analyses and univariate and multivariate cos regression results revealed C5orf58, NDC1, LINC00501 and G6PD could be prognostic signatures of HCC. The prediction value was validated and pan-cancer analyses also demonstrated multiple function of the key eRNA and its target genes.
Conclusion
A novel eRNA AL137803.1 may be a potential biomarker of HCC, besides its putative target genes may serve as prognostic signatures.
Oral Nirmatrelvir and Severe Covid-19 Outcomes During the Omicron Surge
Authors: Arbel Ronen , Sagy Yael Wolff , Hoshen Moshe , Battat Erez , Lavie Gil , Sergienko Ruslan , Friger Michael , Peretz Alon , Yaron Shlomit , Serby Danielle , Hammerman Ariel , Netzer Doron
Published: June 2022

Background
Nirmatrelvir, an inhibitor of the main protease of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has demonstrated a significant decrease in the risk of progression to severe disease in symptomatic high-risk patients infected with the B.1.617.2 (delta) variant of SARS-CoV-2. The effectiveness of nirmatrelvir against the B.1.1.529 variant (omicron) is unknown.
Methods
The study included all Clalit Health Services members, 40 years of age and older, with confirmed infection of SARS-CoV-2 during the omicron surge that were defined as high-risk for severe disease. A Cox proportional-hazards regression model with time-dependent covariates was used to estimate the association between nirmatrelvir treatment and hospitalizations and deaths due to Covid-19, with adjustment for individual sociodemographic factors, coexisting conditions, and prior Covid-19 immunity status.
Results
109,213 participants were eligible for nirmatrelvir therapy during the two-month study period. Among the 42,819 eligible patients aged 65 years and above, 2,504 were treated with nirmatrelvir. Hospitalizations due to Covid-19 occurred in 14 out of the treated and 762 of the untreated patients: adjusted HR 0.33 (95% CI, 0.19 to 0.55). Death due to Covid-19 occurred in 2 treated and 151 untreated patients; adjusted HR: 0.19 (95% CI, 0.05 to 0.76). Among the 66,394 eligible patients 40 to 64 years of age, 1,435 were treated with nirmatrelvir. Hospitalizations due to Covid-19 occurred in 9 treated and 334 untreated patients: adjusted HR 0.78 (95% CI, 0.40 to 1.53). Death due to Covid-19 occurred in 1 treated and 13 untreated patients; adjusted HR: 1.64 (95% CI, 0.40 to 12.95).
Conclusions
Nirmatrelvir therapy was associated with a 67% reduction in Covid-19 hospitalizations and an 81% reduction in Covid-19 mortality in patients 65 years and above. However, no significant benefit in avoidance of severe Covid-19 outcomes was shown in younger adults.
Crystal-storing histiocytosis in the gastric: a case report and review of the literature
Authors: Kong Linghong , Xue Liyan , Zhong Yanfeng , Wang Shenglan , Zheng Danfeng , Wang Lining , Jiao Yang , Zhang Xinpeng , Xue Huizhong , Liu Xiaogang
Published: June 2022

Background: Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of nonneoplastic histiocytes containing intracytoplasmic crystallized immunoglobulins. Although CSH can occur in a variety of organs, including the bone marrow, lungs, lymph nodes, liver, spleen, and kidney, gastric CSH is very rare. Case presentation: We present a 69-year-old man with localized gastric CSH, presenting as positive fecal occult blood for 2 days. Gastroscopy showed that there was a piece of irregular whitish focus in the big bend of gastric antrum, which was soft and elastic. Histologically, the biopsied gastric mucosa showed chronic inflammation, mild activity with erosion, and a large number of eosinophilic mononuclear cells containing fibrillary crystalloid inclusion in the lamina propria. Immunohistochemically, these crystal-containing cells were positive for CD68/PGM1 and Igk, which revealed that the cells were histiocytes harboring kappa light chain-restricted immunoglobulin crystals. Electron microscopic examination showed that a large number of high electron density particles were found in the cytoplasm of cells, with the crystal structure, different sizes and shapes.Conclusion: Since this entity is rare and unfamiliar, difficulties in diagnosis may arise. We present a case of localized CSH associated with just such an incidental gastric lesion and reviewed the related literature, in order to improve our understanding of it and avoid misdiagnosis.
Research on marine atmospheric corrosion behavior of AZ31 magnesium alloy based on scientific ocean voyage
Authors: Yang Lihui , Wang Ying , Xu Weichen , Wang Xiutong , Li Yantao , Huang Yanliang , Hou Baorong
Published: June 2022

Corrosion behavior of AZ31 magnesium alloy based on marine scientific ocean voyage was investigated by using scanning electron microscope (SEM), X-Ray Diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and electrochemical measurements. The results revealed that the AZ31 magnesium alloy suffered serious corrosion during exposure in marine atmosphere of ocean voyage. The corrosion rate was 52.23 μm∙y−1 and the maximum depth of corrosion pits was 105.84 μm after exposure for 1 year. The main corrosion products formed on AZ31 magnesium were Mg5(CO3)4(OH)2·4H2O, MgCO3·3H2O and Mg2(OH)3Cl·4H2O. Chloride ion plays an important role in the corrosion process of AZ31 magnesium alloy during ocean voyage. The corrosion of AZ31 magnesium alloy was initiated from pitting corrosion and evolved into general corrosion. This study will provide effective data for the application of magnesium alloy in marine equipment.
Women’s perceptions and experiences of medical treatment for incomplete abortion in Malawi: a mixed methods study
Authors: Chakhame Bertha Magreta , Darj Elisabeth , Mwapasa Mphatso , Kafulafula Ursula Kalimembe , Maluwa Alfred , Odland Jon Øyvind , Odland Maria Lisa
Published: June 2022

Background
Abortion related complications are among the leading causes of maternal mortality in Malawi. Misoprostol is recommended for the treatment of first trimester incomplete abortions but is seldom used for post abortion care in Malawi.
Methods
A descriptive cross-sectional study that used mixed methods was conducted in 3 hospitals in central Malawi. A survey was done on 400 women and in-depth interviews with 24 women receiving misoprostol for incomplete abortion. Convenience and purposive sampling methods were used and data were analysed using STATA 16.0 for quantitative part and thematic analysis for qualitative part.
Results
Data are presented in tables and narratives, three themes emerged around the following areas: experienced effects, support offered, and women’s perceptions. Almost all participants reported having received drugs and counselling as support from health care workers. The majority of participants, 94%, reported satisfaction with the support and described misoprostol as helpful and effective in expelling retained products of conception. Misoprostol was preferred and regarded as the most reliable treatment and beneficial to women by most participants. The majority of the women reported tolerable effects of the drug and 91% would recommend misoprostol to friends.
Conclusions
The use of misoprostol for incomplete abortion in Malawi is acceptable and regarded as helpful and satisfactory among women.
Trial registration:
Not applicable
Microbe Killer Polymeric Films Made by Melt-Compounding and Compression of Peptide Assemblies and Polyethylene
Authors: Kaganovich Michaela , Shlosman Koranit , Goldman Evgeniya , Benchis Marina , Eitan Tamar , Shemesh Rotem , Gamliel Abraham , Reches Meital
Published: June 2022

This paper presents, for the first time, compression molding of peptide assemblies with low-density polyethylene (LDPE) for the robust production of antimicrobial polymeric films. The peptide self-assembles in an aqueous medium into spherical structures with antimicrobial properties. After lyophilization, used to yield a fine powder, these particles were melt-compounded at 160°C with LDPE, followed by compression molding to produce 100 µm thick polymeric films. These films showed a significant reduction in the number of bacteria, viruses, and fungi. These innovative active polymeric films can potentially be applied for medical device wrapping, food packaging, and agriculture applications where crop protection is needed.
Hormesis effect and management of thiophanate-methyl resistance in Lasiodiplodia theobromae isolates
Authors: Silva Erivaldo Laurentino da , Garzón Carla D. , Lopes Ueder Pedro
Published: June 2022

Peduncular rot caused by Lasiodiplodia theobromae is one of the main diseases in papaya crop (Carica papaya). Resistance to the fungicide thiophanate-methyl has been found in isolates of this pathogen in the northeast of Brazil which threatens the productivity of this crop. Therefore, the goals of this study were to evaluate the sensitivity of thiophanate-methyl resistant L. theobromae isolates to other fungicides, and to investigate the hormetic effect of fungicides on populations of the pathogen, aiming at identifying alternatives to manage this important disease. In vitro and in situ assays were conducted, using two fungicides currently registered for management of papaya diseases, as well as some not registered. Demethylation inhibitor fungicides were the most effective to control resistant isolates in vitro. While imazalil, metconazole and tebuconazole were still effective to control papaya peduncular rot, thiabendazole, a fungicide registered to prevent the disease postharvest. This fungicide was ineffective on a resistant isolate and increased its virulence. Additionally, stimulation of mycelial growth in vitro and virulence were observed in the resistant isolate due to exposure to subinhibitory doses of thiophanate-methyl. These observations suggest the need for new strategies to manage the disease in areas with a history of resistance. The fungicide imazalil, registered for postharvest of papaya, is currently a good option to control L. theobromae isolates. Metconazole and tebuconazole, although not registered for this crop, have potential to manage the disease in areas with a history of resistance to thiophanate-methyl.
Injectable oxygen liberating hydrogels increase survival and innervation of neural stem cell grafts prior to vascularization
Authors: Wang Yi , Thomas Jacob , Hong Nansook , Tan Li Lynn , McGillivray Duncan , Perriman Adam , Moriarty Niamh , Parish Clare L , Williams Richard , Jackson Colin , Nisbet David
Published: June 2022

Injectable hydrogels have great potential for use in regenerative medicine as cellular delivery vectors. However, as with other cell-laden transplantable materials, they suffer from issues relating to hypoxia, including poor cell survival, differentiation, and functional integration owing to the lack of an established vascular network. Here, we have engineered a hybrid myoglobin:peptide hydrogel that can concomitantly deliver stem cells and oxygen to the brain to support engraftment until vascularisation can occur naturally. This hybrid hydrogel can modulate cell fate specification within progenitor cell grafts, resulting in a significant increase in neuronal differentiation. The addition of myoglobin to the hydrogel resulted in more extensive innervation within the host tissue from the grafted cells, which is essential for neuronal replacement strategies to ensure functional synaptic connectivity. Further development of this approach could result in greater functional integration of stem cell-derived grafts for the treatment of neural injuries and diseases affecting the central and peripheral nervous systems.
Persepsi terhadap Kondisi Pelestarian Bangunan Cagar Budaya yang Menjadi Atraksi Wisata di Kotagede
Authors: Nursyamsu Lathifa , Marcillia Syam Rachma
Published: June 2022

Kotagede merupakan satu dari 5 Kawasan Cagar Budaya (KCB) yang ada di Yogyakarta dan memiliki banyak Bangunan Cagar Budaya (BCB). Selain menjadi KCB, Kotagede juga merupakan salah satu destinasi wisata yang cukup populer di Yogyakarta yang kaya akan atraksi wisata yang bernilai sejarah dan budaya. Beberapa atraksi tersebut merupakan BCB. Namun, sangat disayangkan sebagai KCB dengan atraksi wisata andalan berupa BCB, kondisi pelestarian BCB di KCB Kotagede berada paling buruk diantara KCB lainnya di Yogyakarta. Sehingga perlu penelitian lebih lanjut untuk melihat kondisi BCB yang menjadi atraksi wisata di Kotagede, apakah berada dalam kondisi pelestarian yang baik atau kurang baik, serta bagaimana pengaruh pariwisata terhadap pelestarian BCB. Penelitian ini menggunakan metode penelitian kualitatif dengan pengumpulan data melalui wawancara mendalam (depth interview) kepada pengelola yang disertai pemberian skor. Hasil dari penelitian ini menunjukkan bahwa pelestarian BCB yang menjadi atraksi wisata di Kotagede berada dalam kondisi baik. Salah satu upaya pelestarian BCB yakni dengan pemanfaatannya pada sektor pariwisata. Dalam penelitian ini ditemukan bahwa pariwisata berdampak positif terhadap pelestarian BCB di Kotagede karena mendukung pengelola untuk memelihara BCB dengan baik guna memberikan kepuasan kepada wisatawan. Selain itu, pariwisata juga memberikan manfaat ekonomi yang dapat digunakan untuk pelestarian BCB.
DIMENSIONS AND APPLICATIONS OF TEACHER SPIRITUALITY IN THE DEVELOPMENT OF ISLAMIC PRIMARY SCHOOL TEACHER COMPETENCY IN TANGGAMUS DISTRICT
Authors:   Post-Graduate Program of Islamic Education Management Study Post-Graduate Program of Islamic Education Management Study Program , Raden Intan State Islamic University of Lampung, Indonesia.Program , Raden Intan State Islamic University of Lampung, Indonesia., a Sundusiah , Kholid Idham ,   Post-Graduate Program of Islamic Education Post-Graduate Program of Islamic Education Management Study Program , Raden Intan State Islamic University of Lampung, Indonesia.Management Study Program , Raden Intan State Islamic University of Lampung, Indonesia., Diana Nirva ,   Post-Graduate Program of Islamic Education Management Study Program , Raden Intan State Islamic University of Lampung, Indonesia., b Zulhannan ,   Post-Graduate Program of Islamic Education Management Study Program , Raden Intan State Islamic University of Lampung, Indonesia.
Published: June 2022

Teacher competence is a crucial factor in the sustainability of the educational process. However, the portrait of the low competence of teachers is still a severe problem in the process of implementing education. The development of teacher work spirituality is believed to be a significant factor in efforts to increase teacher competence more effectively. This study aims to reveal which aspects of the pedagogic, personality, social, and professional competencies of MI teachers in Tanggamus Regency require development and to what extent the work spirituality framework can be developed and applied to promote these competencies. The method used in this research is descriptive qualitative with a case study approach. Data were obtained from direct interviews, observation, and documentation of teachers, madrasah principals, and madrasah ibtidaiyah supervisors in Tanggamus district and were analyzed with data reduction, data display, and data verification. The results of the study explain that there are many aspects of the competence of Madrasah Ibtidaiyah teachers in Tanggamus, especially pedagogic competence and professional competence, that have not shown satisfactory results. Therefore, development efforts should be thoughtfully made by all relevant parties. In addition, the description of the research data also finds the potential for teacher work spirituality that can be optimized with the correct principles and implementation strategies to support the development of all madrasa teacher competencies and improve the quality of learning more effectively.
PLATELET CONCENTRATION - A NEWER CONCEPT FOR PERIODONTAL REGENERATION
Authors:   Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Himalaya Encl, Vrindavan Yojna, Lucknow 226301, India., Sahney Tanu
Published: June 2022

Platelet concentrates are the derivatives of blood which helps in haemostasis and wound healing after periodontal regenerative procedures. These are prepared from the patients own blood throughout which the activated platelets become close and form a fibrin matrix scaffold that releases growth factors and cytokines which plays a key role in tissue regeneration including cell proliferation and differentiation, extracellular matrix synthesis, chemotaxis and angiogenesis. This review highlights various types of platelet concentrates, and their clinical applications within the treatment of periodontal diseases.
AN INSIGHT INTO THE OCCLUSAL SPLINT THERAPY FOR THE MANAGEMENT OF TEMPOROMANDIBULAR JOINT DISORDERS
Authors: Raghavan Rohit , P.A Shajahan , R.S Shilpa
Published: June 2022

For many years the occlusal splint therapy has been practiced for the diagnosis and treatment of various temporomandibular joint disorders. Many designs have been discussed in the literature. Each of these occlusal appliances are used for specific conditions. A proper examination and diagnosis is essential for selecting the appropriate appliance for that particular situation. This article reviews about the types, designs and materials used for occlusal splint fabrication. The present article also familiarizes the individual application and uses of each occlusal splint.
VITAMIN D LEVEL STATUS OF CHILDREN OF DISTRICT SHOPIAN WITHOUT RICKETS.
Authors: Ahmad Lone Rais , Imran Padder Mohamad , Shahid Hussain Wani
Published: June 2022

Background: Vitamin D is not actually a vitamin but its deficiency can have deleterious effects in children. The prevalence of vitamin D deficiency ranges from 40 to 90 % in the Indian subcontinent and as much as 40% in the European population for one or the other reasons. Objective: To assess the serum Vitamin D level status of children of district Shopian without rickets. Method: We sampled 60 children aged 1 year to 12 years who attended the hospital for common reasons randomly and their serum vitamin D levels determined after proper and detailed history. Results: Of the 60 children, 66.67% were found to be deficient, 26.7% were found to be insufficient and only 6.66% were found to be sufficient. Conclusion: This study finds that the prevalence of Vitamin D deficiency is very high in the children of district Shopian & a survey with a very large sample size will be ideal and vitamin D supplementation be instituted regularly by the healthcare bodies on the recommended guidelines.
INNATE IMMUNE CELLSIN IMMUNE TOLERANCE AFTER LIVER TRANSPLANTATION
Authors:   General Physician / Medical Researcher and Writer Lugansk State Medical University - Luhansk Oblast, 93000 Luhansk, Ukraine., Dahal Tshetiz , Rizal Subarna ,   East West Medical College , Dhaka University General Physician.
Published: June 2022

Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immuno-suppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to the immuno-suppressive therapy have led to the development of new protocols aimed at protecting renal function and preventing de novo cancer and dysmetabolic syndrome. Donor specific immune tolerance, which means the mature immune systems of recipients will not attack the grafts under the conditions without any immunosuppression therapies, is considered the optimal state after liver transplantation. There have been studies that have shown that some patients can reach this immune tolerance state after liver transplantation. The intrahepatic immune system is quite different from that in other solid organs, especially the innate immune system. It contains a variety of liver specific cells, such as liver-derived dendritic cells, Kupffer cells, liver sinusoidal endothelial cells, liver-derived natural killer (NK) cells, natural killer T (NKT) cells, and so on. Depending on their specific structures and functions, these intrahepatic innate immune cells play important roles in the development of intrahepatic immune tolerance. In this article, in order to have a deeper understanding of the tolerogenic functions of liver, we summarized the molecular mechanisms of immune tolerance induced by intrahepatic innate immune cells after liver transplantation.
OCCLUSION GRELELIQUE SUR DIVERTICULE DE MECKEL : A PROPOS DUN CAS
Authors:   Service de Chirurgie A Avicenne Rabat., Ihab Youssef , Talbi Ibtissam ,   Service de Chirurgie A Avicenne Rabat., a Fatimaazahraabenmoula ,   Service de Chirurgie A Avicenne Rabat., b Hajomarmalki ,   Service de Chirurgie A Avicenne Rabat., c Mountassirchefchaouni ,   Service de Chirurgie A Avicenne Rabat., d LahcenIfrine ,   Service de Chirurgie A Avicenne Rabat., Belkouchi Abdelkader ,   Service de Chirurgie A Avicenne Rabat.
Published: June 2022

Le diverticule de Meckel est un reliquat embryologique du canal omphalo-mesenterique situe sur le dernier tiers de lintestin grele. Il est le vestige du canal vitellin situe a 60-80 cm environ de la jonction ileo-cÃ¦caleCe diverticule peut se perforer, senflammer aussi causer une occlusion. Nous rapportons le cas dun homme Ã¢ge de 30 ans, hospitalise et pris en charge au service des urgences chirurgicale viscerale de CHU IBN SINA de Rabat pour occlusion intestinale et dont le constat per operatoire etait un volvulus du grele sur diverticule de Meckel avec necrose intestinale. Son evolution etait bonne aprÃ¨s lintervention chirurgicale.
CASE REPORT OF INGUINAL BLADDER HERNIA
Authors:   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Gomah Hamed Alaqqad Mohamed , Abdelfattah Elmowafi Badran Reda ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abou El Foul Rami ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Samir Mokhtar Hamed Elwan Mohammed ,   Radiology Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Intesar Mehdi Kazmi Syed ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Babiker Sulaiman Hashash Ammar ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Ram Leela ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Mustafa Abdalla Gumaa Ashraf ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Elhassan Omer Elhassan Nessrein ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abouelfetouh Abouelfetouh Elsharkawi Mohamed ,   Emergency Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abdallah Elsayed Ahmed Zied Elsayed ,   Emergency Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates.
Published: June 2022

Inguinal bladder hernia is a rare condition. The diagnosis is established either pre-operative by Ultrasound or intra operatively if not noticed before surgery. It is important to diagnose the problem and at the same time to avoid any damage or unexpected complication during surgery by good preparation and with expert hands. Theoutcome of surgery depends on many factors like the size of hernia, adhesions and abnormal anatomy or bladder diverticulum. Repositioning and catheterization of the bladder would be appropriate and safe way of management.
A CASE REPORT OF CHYLOUS ASCITES AND TRANSIENT MIDGUT VOLVULUS THROUGH PETERSENS DEFECT THREE YEARS POST ONE-ANASTOMOSIS GASTRIC BYPASS- MINIGASTRIC BYPASS
Authors:   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abdelfattah Elmowafi Badran Reda , Gomah Hamed Alaqqad Mohamed ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abou El Foul Rami ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Samir Mokhtar Hamed Elwan Mohammed ,   Radiology Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Intesar Mehdi Kazmi Syed ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Babiker Sulaiman Hashash Ammar ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Ram Leela ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Mustafa Abdalla Gumaa Ashraf ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Elhassan Omer Elhassan Nessrein ,   General Surgery Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abouelfetouh Abouelfetouh Elsharkawi Mohamed ,   Emergency Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates., Abdallah Elsayed Ahmed Zied Elsayed ,   Emergency Department, Hatta Hospital, Dubai Health Authority, United Arab Emirates.
Published: June 2022

One-anastomosis gastric bypass- Minigastric bypass (OAGB-MGB) is an emerging bariatric surgery technique replacing the RYGP with reasonable short- and long-term side effects. Here we would like to present a late complication of OAGB-MGB associated with signs of peritoneal irritation and severe pain due to transient midgut volvulus associated with chylous ascites.. We observed peritoneal lymphatic collection in association with features suggestive for small bowel obstruction 3 years followingOAGB-MGB. So, we believe that such complication should be considered as a potential side effect during short and long term follow up after gastric bypass.A strong recommendation should be provided.
CHEMICAL COMPOSITION, ANTIOXIDANT AND ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL OF TRACHYSPERMUMAMMISEEDS
Authors:   Centre for Rural Development and Technology, IIT- Delhi, Hauz Khas, Delhi 110016, Tel: (91)-11-2659-1116, Fax: (91)-11-2659-1121., Chowdhary Kanika , Sharma Satyawati ,   Centre for Rural Development and Technology, IIT- Delhi, Hauz Khas, Delhi 110016, Tel: (91)-11-2659-1116, Fax: (91)-11-2659-1121.
Published: June 2022

The essential oil of locally available Trachyspermumammi(ajowan) seeds was obtained through hydrodistillation. Its chemical composition was analysed by gas chromatography mass spectrometry (GC-MS). Twenty - two compounds of EO were identified with the help of NIST library. Thymol (38.5%), Ï-cymene (27.2%) and Î³-terpinene (26.8%) were identified as major components. Furthermore, its antioxidant power of IC50 value 65.3 Î¼g/ml was determined by DPPH (2, 2- diphenyl-1-1-picrylhydrazyl radical) free radical scavenging activity. In addition, ethanolic suspension of EO exhibited strong inhibition of plant pathogen Sclerotinia sclerotiorumunder in-vitroconditions having IC50 value of 691 ppm.