bluuebunny/crossref_metadata_2025 huggingface dataset:
Early warning of the abnormal response of the generator set electrical control based on SIP concept
Authors: Li Guannan
Published: April 2023

An early warning method based on Session Initiation Protocol (SIP) concept for generator set electrical control abnormal response is proposed. The first is to clean the electrical data of the generator set by SIP. Using Supervisory Control and Data Acquisition (SCADA) and Generalized Linear Models (GLM) algorithm, a linear model is constructed to analyze the electrical control of generating units. Using the Autoregressive Integrated Moving Average Model (ARIMA), an abnormal response early warning model for electrical control of generating units is established. BP neural network is used to train the abnormal response data of the generator set electrical control. According to the current response data, the model prediction is realized, and the early warning of the abnormal response of the generator set electrical control is effectively realized. The simulation results show that the proposed method can effectively reduce the early‐warning error, false alarm rate, and early‐warning delay of generator electrical control abnormal response.
Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia
Authors: Shen Jing , Chen Guobo , Zhao Linghao , Huang Guoyang , Liu Hui , Liu Baolin , Miao Yuqing , Li Yuhao
Published: April 2023

Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy including chemotherapy, radiotherapy, photodynamic therapy, etc. In recent years, the construction of hypoxia‐relieving functional nanoplatforms through nanotechnology has become a new strategy to reverse the current situation of tumor microenvironment hypoxia and improve the effectiveness of tumor treatment. Here, the main strategies and recent progress in constructing nanoplatforms are focused on to directly carry oxygen, generate oxygen in situ, inhibit mitochondrial respiration, and enhance blood perfusion to alleviate tumor hypoxia. The advantages and disadvantages of these nanoplatforms are compared. Meanwhile, nanoplatforms based on organic and inorganic substances are also summarized and classified. Through the comprehensive overview, it is hoped that the summary of these nanoplatforms for alleviating hypoxia could provide new enlightenment and prospects for the construction of nanomaterials in this field.
Mobile Kink Solitons in a Van der Waals Charge‐Density‐Wave Layer
Authors: Lee Jinwon , Park Jae Whan , Cho Gil Young , Yeom Han Woong
Published: April 2023

Kinks, point‐like geometrical defects along dislocations, domain walls, and DNA, are stable and mobile, as solutions of a sine‐Gordon wave equation. While they are widely investigated for crystal deformations and domain wall motions, electronic properties of individual kinks have received little attention. In this work, electronically and topologically distinct kinks are discovered along electronic domain walls in a correlated van der Waals insulator of 1T‐TaS2. Mobile kinks and antikinks are identified as trapped by pinning defects and imaged in scanning tunneling microscopy. Their atomic structures and in‐gap electronic states are unveiled, which are mapped approximately into Su–Schrieffer–Heeger solitons. The twelvefold degeneracy of the domain walls in the present system guarantees an extraordinarily large number of distinct kinks and antikinks to emerge. Such large degeneracy together with the robust geometrical nature may be useful for handling multilevel information in van der Waals materials architectures.
A Ternary Composite with Medium Adsorption Confirms Good Reversibility of Li‐Se Batteries
Authors: Li Yi , Li Zhao , Yue Liang , Zhang Yi , Liu Shuang , Niu Yubin , Zhang Sam , Xu Maowen
Published: April 2023

For Li‐Se batteries, cathode using carbonaceous hosts to accommodate Se performed modestly, whereas those applying metallic compounds with stronger chemical adsorption exhibited even more rapid capacity decay, the intrinsic reasons for which are still not clear. Herein, it is found that Se tends to precipitate on the surface of the electrode during cycling, and the precipitation speed depends on the polarization degree of the host. A further enhanced adsorption does not certainly generate better electrochemical activity, since hosts with overhigh adsorption ability are hard to desorb polyselenides, leading to catalyst passivation and rapid capacity decay. These findings encourage us to design a ternary anatase/rutile/titanium nitride (aTiO2/rTiO2/TiN@C) composite host, integrating good adsorption of TiO2 and rapid electron transport ability of TiN, and introducing rutile to weaken overall adsorption. The aTiO2/rTiO2/TiN@C composite with medium adsorption not only avoids rapid loss of active substances in electrolyte but also slows down the precipitation speed of Se. As a result, the aTiO2/rTiO2/TiN@C/Se electrode delivered good rate capability(154 mA h g−1 at 20 C) and good cycling stability(a low decay of 0.024% per cycle within 500 cycles at 2 C).
“Give up your mic”: Building capacity and sustainability within community‐based participatory research initiatives
Authors: April Keisha , Stenersen Madeline R. , Deslandes Maguena , Ford Taylor C. , Gaylord Patricia , Patterson Jacqúese , Wilson Beresford , Kaufman Joy S.
Published: April 2023

Community‐based participatory research (CBPR) partnerships strive to promote community capacity building and sustainability, yet initiatives often suffer when grants or relationships with academic partners end. To address these concerns, researchers hoping to develop truly sustainable CBPR partnerships should consider factors that promote the development of community capacity and, ultimately, independence. In this first‐person account, using perspectives gathered from FAVOR, a Connecticut‐based family‐led advocacy organization and an academic researcher, we examine the practices and experiences of the members of a CBPR partnership focused on using community voice to inform changes in the state's children's behavioral health system of care. These practices ultimately led to FAVOR developing the necessary skills to assume full ownership of the community data‐gathering initiative, ensuring that the initiative would be sustained. Through the perspectives of five FAVOR staff and an academic researcher, we describe the factors that contributed to the organization being able to develop the capacity to independently continue their community data‐gathering initiative, including description of the training process and staff members' perspectives on training, autonomy, community value, and lessons learned. We use these stories and experiences to provide recommendations for other partnerships striving to promote capacity building and sustainability through community ownership of the research process.
Synthesis of multifunctional rubber chemicals 2‐propanol, 1‐(2‐benzothiazolylthio)‐3‐[3‐(triethoxysilyl) propoxy] silane and its application in natural rubber/silica composites
Authors: Sun Abin , Tao Anmin , Yao Binbin , Yu Guangshui , Kan Ze
Published: April 2023

In order to inhibit the agglomeration of silica in the rubber matrix, a new multifunctional rubber chemicals 2‐propanol, 1‐(2‐benzothiazolylthio)‐3‐[3‐(triethoxysilyl) propoxy] silane (Si‐GM) was synthesized by (3‐glycidyloxypropyl) trimethoxysilane (A‐1871) and 2‐mercaptobenzothiazole (MBT). Natural rubber (NR)/silica composites were prepared with different Si‐GM contents and its application in silica/NR composites obtained were researched. Experimental results show that the maximum and minimum torques of silica‐filled NR decrease with increasing the content of Si‐GM. With the addition of Si‐GM, the rubber compound has excellent characteristics of both fast vulcanization rate and high processing safety. Si‐GM can effectively improve the dispersion of precipitated silica in composites and strengthen the interaction between silica particles and NR matrix. It was found that Si‐GM considerably enhanced the mechanical properties such as the tensile and tear strength, dynamic compression property, and abrasion resistance of silica/NR composites, and the enhancements reached the maximum at the 5‐phr content of Si‐GM. In addition, by adding 4‐phr Si‐GM into the system, silica/NR composites acquired the superior comprehensive dynamic performances.
Using simple economic games to assess social orienting and prosocial behavior in adolescents with autism spectrum disorder
Authors: Hase Adrian , Haynes Melanie , Hasler Gregor
Published: April 2023

Deficits in socio‐emotional reciprocity, in prosocial behavior and in developing social relationships are diagnostic criteria of autism spectrum disorder (ASD), usually assessed by self‐report or observation. Simple social experiments developed by behavioral economists allow for quantification of ASD‐related social behavior. In this study, we used such experiments to compare social‐economic decision‐making between ASD adolescents and neurotypical controls. Precisely, we analyzed social orienting and prosocial behavior in 17 adolescents with ASD (Asperger syndrome) and 24 matched neurotypical adolescents. We used a two‐condition distribution game (possibility of punishment by fellow player versus no such possibility) and an impunity game to examine social orienting (distribution game) and prosocial behavior (both games). Participants with ASD exhibited less social orienting in the distribution game (p = 0.03, d = −0.61). In addition, there was a trend for ASD participants to behave in a more prosocial way than neurotypical participants in the impunity game (p = 0.08, d = 0.60), which was not the case in the no‐punishment condition of the distribution game (p = 0.35, r = 0.17). These results demonstrate the potential of simple economic games to capture reduced social orienting in ASD. The unexpected finding of more prosocial behavior in adolescents with autism spectrum disorder than in neurotypical controls adds to the complexity of previously published results. We recommend meta‐analytic efforts to determine average effect sizes across studies and elucidate the conditions for prosocial behavior in ASD to occur.
High‐Mass‐Loading CoNi‐Layered Double Hydroxide Directly Grown on Brush‐like Cu/Carbon Cloth as High‐Areal‐Capacitance Supercapacitor Electrode
Authors: Feng Yichen , Yang Zhuang , Fang Yu‐Hung , Chen Ying‐Chu , Hsu Yu‐Kuei
Published: April 2023

A combination of high mass loading and efficient utilization of electroactive materials is crucial for simultaneously enhancing the energy and power densities of energy storage devices. This is exemplified herein using cobalt nickel layered double hydroxides nanosheets (CoNi‐LDHs) directly grown on copper nanowires (Cu NWs) standing quasi‐vertically on carbon cloth (CC) to yield a multi‐core‐shell CoNi‐LDHs/Cu NWs/CC as the supercapacitor electrode that exhibits a high areal capacitance of 5.55 F cm−2 (corresponding to a gravimetric capacitance of 1209.15 F g−1) at a large current density of 10 mA cm−2. Such superior rate capability is attributed to the high packing density of CoNi‐LDHs in the electrode, benefitting from the large specific surface area of Cu NWs/CC. Additional contribution stems, on the other hand, from the facile charge transfer kinetics resulted from the elimination of binder from the electrode coupled with the mesopores between not only Cu NWs but also CoNi‐LDHs nanosheets, and the macropores between the carbon fiber of CC. Benefitting from such exceptional rate performance is the supercapacitor built on CoNi‐LDHs/Cu NWs/CC as the positive electrode coupled with bismuth subcarbonate (Bi2O2CO3) as the negative electrode capable of delivering outstanding power density of 13.31 mW cm−2 and energy density of 0.35 mWh cm−2.
Refining the Grain Size of Zinc Electrodeposit by Pb2+ Ion Grinding for Compact and Stable Zinc Anode
Authors: Cui Yang‐Feng , Cao Ren‐Fei , Hao Qi , Zhuang Zhen‐Bang , Xie Zi‐Long , Chen Hao , Li Kai , Wang Qingshuang , Liu Wan‐Qiang , Yang Yingkui , Huang Gang , Zhu Yunhai
Published: April 2023

Recently, aqueous zinc‐based batteries (AZBs) have become a promising candidate for energy storage devices due to the high safety of aqueous electrolytes and the appealing features of Zn anodes, for example, low cost and high theoretical capacity. However, the excessive growth of Zn electrodeposits as well as the uneven stacking of large hexagonal Zn crystal units always render loose and irregular electrodeposition or even dendritic growth, which seriously deteriorates the actual performance of AZBs. Herein, to refine the grain size of Zn electrodeposits, a trace of Pb2+ ions as a novel electrolyte additive is performed to inhibit the growth of Zn grain during the Zn electrodeposition. Owing to the higher adsorption energy of Pb2+ ions on Zn crystal when compared with Zn2+ ions, the strongly positively‐charged Pb2+ ions are tightly absorbed on the typical crystal planes of initially‐formed Zn nuclei, which block the way for the subsequent absorption and electroreduction of Zn2+ ions. As a result, the Pb2+ ions‐containing electrolyte refines the grain size of Zn electrodeposits from 7.43–7.87 μm to 0.88–2.26 μm, and affords a high reversibility of Zn plating/stripping behavior with a high Coulombic efficiency of 99.9 % over 1000 cycles.
Determination of the absolute Raman cross‐sections of α‐S8 film at ultralow frequencies pumped by 488 and 785 nm lasers
Authors: Shin Mingyeong , Park Jinsun , Jeong Keunhong , Park Myeongkee
Published: April 2023

Absolute Raman cross‐sections are widely used for quantitative analyses of condensed phases. However, solid thin films showing ultralow frequency (ULF) Raman characteristics at <100 cm−1 have not been studied deeply. Herein, we demonstrate an ULF Raman spectrometer equipped with 488 and 785 nm pumped lasers and determine the absolute Raman cross‐sections of 34‐μm‐thick α‐S8 film, which presents Raman peaks at approximately 27, 50, 83, 154, and 220 cm−1. These experimentally measured ultralow Raman frequencies and Raman cross‐sections were also confirmed via first principles density functional theory. Thus, our Raman cross‐section studies can be utilized as a quantitative standard for thin films showing ULF Raman characteristics.
Liquid chromatography coupled with tandem mass spectrometry for simultaneous quantification of valproate, valproate‐glucuronide and lamotrigine in various biological matrices of rat
Authors: Qiu Fiona , Nie Shuai
Published: April 2023

Valproate and lamotrigine are commonly used as antiepileptic drugs even in pregnant and breastfeeding women. The extent and effects of drug exposure on the developing brain of the offspring are not well understood. Animal models can be utilised to investigate the transfer of substances into fetal brain with the ultimate aim of providing insights to aid clinical decisions. In the present study, an LC–MS/MS method was developed and validated for quantification of valproate (VPA), valproate‐glucuronide (VPA‐Gluc, a major metabolite of valproate) and lamotrigine (LTG) in rat blood plasma, cerebrospinal fluid and brain tissue. A 10 μl sample was spiked with stable isotope‐labelled internal standards and extracted by methanol. An Agilent RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) was used. The MS/MS transitions were 143.1016–143.1016 (VPA), 319.1392–143.0978 (VPA‐Gluc) and 256.0157–210.9826 (LTG). The linear ranges of VPA, VPA‐Gluc and LTG were 30–250, 10–140 and 0.3–1 μg/ml, respectively. The intra‐ and inter‐day accuracy and precision, carryover, sensitivity and recovery were evaluated according to the US Food and Drug Administration guidance for bioanalytical method validation. Finally, the validated method was applied to a set of experimental animal samples and produced results highly comparable with those from an orthogonal analytical method.
Engineering a conduction‐consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell‐derived cardiomyocytes
Authors: Tan Yao , Lu Tingting , Chen Ying , Witman Nevin , Yan Bingqian , Yang Li , Liu Minglu , Gong Yiqi , Ai Xuefeng , Luo Runjiao , Wang Huijing , Wang Wei , Fu Wei
Published: April 2023

Engineering a conduction‐consistent cardiac patch has direct implications to biomedical research. However, there is difficulty in obtaining and maintaining a system that allows researchers to study physiologically relevant cardiac development, maturation, and drug screening due to the issues around inconsistent contractions of cardiomyocytes. Butterfly wings have special nanostructures arranged in parallel, which could help generate the alignment of cardiomyocytes to better mimic the natural heart tissue structure. Here, we construct a conduction‐consistent human cardiac muscle patch by assembling human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) on graphene oxide (GO) modified butterfly wings. We also show this system functions as a versatile model to study human cardiomyogenesis by assembling human induced pluripotent stem cell‐derived cardiac progenitor cells (hiPSC‐CPCs) on the GO modified butterfly wings. The GO modified butterfly wing platform facilitated the parallel orientation of hiPSC‐CMs, enhanced relative maturation as well as improved conduction consistency of the cardiomyocytes. In addition, GO modified butterfly wings enhanced the proliferation and maturation characteristics of the hiPSC‐CPCs. In accordance with data obtained from RNA‐sequencing and gene signatures, assembling hiPSC‐CPCs on GO modified butterfly wings stimulated the differentiation of the progenitors into relatively mature hiPSC‐CMs. These characteristics and capabilities of GO modified butterfly wings make them an ideal platform for heart research and drug screening.
Influence of superheated steam treatment on physicochemical, edible, and storage characteristics of highland barley grains
Authors: Liu Xinru , Fu Shijian , Deng Jiawen , Chen Zhicheng , Zhao Beibei , Li Hua
Published: April 2023

Background and Objectives

The effects of superheated steam (SS) processing conditions on physicochemical properties and edible qualities of highland barley (HB) grains are still not clear enough. The storage stability of SS treated HB grains is also need to be verified through long‐term storage. Effects of SS treatment on physicochemical, edible and storage properties of HB grains were investigated.

Findings

SS processing significantly reduced peroxides and polyphenol oxidase activities. Pasting properties showed that SS treatment resulted in significant increase of viscosity parameters. With improved hardness, gumminess, chewiness, and decreased cooking loss, the cooking and textural qualities were improved by SS processing. Storage properties showed that SS processing inhibited the increase of free fatty acid value, peroxide value and carbonyl value during storage, indicating that the oxidative rancidity of HB grains was retarded. SS treatment also maintained the water hydration properties, pasting properties, and textural properties during 6 months of storage.

Conclusions

SS treatment significantly improved the edible and storage properties of HB grains.
Predictive influence of artificial intelligence‐based body composition analysis in trauma patients with pelvic injuries
Authors: Kolck Johannes , Schäfer Frederik Maximilian , Labbus Kirsten , Wittenberg Silvan , Hosse Clarissa , Auer Timo Alexander , Fehrenbach Uli , Geisel Dominik , Beetz Nick Lasse
Published: April 2023

Background

High‐energy trauma patients represent the ultimate challenge to trauma care and are at risk of injury‐related mortality and morbidity—a common cause of loss of productivity. The aim of this study was to implement computed tomography (CT)‐derived, artificial intelligence (AI)‐based body composition analysis (BCA) to identify predictors of morbidity.

Methods

Retrospectively, we enrolled 104 patients (38 females and 66 males) who underwent CT imaging for assessment of injuries caused by high‐energy trauma (motor vehicle accidents, falls from significant height, or blast injury). We sought to identify risk factors for prolonged length of stay in hospital and intensive care unit (ICU) and fractures requiring pelvic surgery. Cox and logistic regression analysis were performed using BCA parameters as covariates besides conventional risk factors. Additionally, the effects of pre‐existing conditions, obesity, and sarcopenia were analysed.

Results

Increased subcutaneous adipose tissue (SAT), determined by BCA, at hospital admittance is a predictor of prolonged hospital stay (P = 0.02) independent of treatment regime and occurrence of related complications, whereas muscle mass does not influence the length of stay. Individuals with sarcopenia and a decreased psoas muscle index (PMI) sustaining high‐energy trauma are at risk of pelvic injuries requiring surgical treatment.

Conclusion

BCA parameters are easily available from routine CT and significantly predict outcomes in trauma patients with pelvic injuries. Patients with reduced muscle mass are at risk for injuries requiring pelvic surgery, and increased SAT is a risk factor for longer hospital stays. These findings underline the potential of BCA, which may be valuable in identifying trauma patients who require specific support to optimize their physiological reserves and clinical outcome.
Benefits of the four‐day workweek
Authors: Freebairn‐Smith Laura
Published: April 2023

In this month's column, which is adapted from my forthcoming book, Abundance Leaders: Creating Energy, Joy, and Productivity in an Unsettled World, which Wiley is releasing in the fall of 2023, I will talk about the four‐day work week.
Stratsi Kulinsky: Creating a new type of university
Authors: D'Orio Wayne
Published: April 2023

Today might seem like the worst time to begin a new university. Not only is the public increasingly losing confidence in the value of a college degree, but an upcoming enrollment cliff will decrease the number of high school graduates by about 15%.
A follow‐up questionnaire survey 2022 on radiation protection among 464 medical staff from 34 endoscopy–fluoroscopy departments in Japan
Authors: Hayashi Shiro , Takenaka Mamoru , Kogure Hirofumi , Yakushijin Takayuki , Nakai Yousuke , Ikezawa Kenji , Yamaguchi Shinjiro , Fujisawa Toshio , Tamaru Yuzuru , Maetani Iruru , Maruyama Hirotsugu , Asai Satoshi , Takagi Tadayuki , Nagaike Koji , Hori Yasuki , Sumiyoshi Tetsuya , Tsumura Hidetaka , Doyama Hisashi , Yoshio Toshiyuki , Hara Kazuo , Abe Seiichiro , Oda Ichiro , Kato Motohiko , Nebiki Hiroko , Mikami Tatsuya , Miyazaki Masanori , Matsunaga Kazuhiro , Hosono Makoto , Nishida Tsutomu ,   REX‐GI Study Group
Published: April 2023

Objectives

We surveyed and reported low protective equipment usage and insufficient knowledge among endoscopy‐fluoroscopy departments in Japan in 2020. Two years later, we conducted a follow‐up survey of doctors, nurses, and technologists in Japan.

Methods

We conducted a questionnaire survey on radiation protection from May to June 2022. The participants were medical staff, including doctors, nurses, and radiological and endoscopy technicians in endoscopy‐fluoroscopy departments. The questionnaire included 17 multiple‐choice questions divided into three parts: background, equipment, and knowledge.

Results

We surveyed 464 subjects from 34 institutions. There were 267 doctors (58%), 153 nurses (33%), and 44 technologists (9%). The rate of wearing a lead apron was 98% in this study. The rates of wearing a thyroid collar, lead glasses, and radiation dosimeter were 27%, 35%, and 74%, respectively. The trend of the protective equipment rate was similar to that of our previous study; however, radiation dosimetry among doctors was still low at 58%. The percentage of subjects who knew the radiation exposure (REX) dose of each procedure was low at 18%. Seventy‐six percent of the subjects attended lectures on radiation protection, and 73% knew about the three principles of radiation protection; however, the concept of diagnostic reference levels was not well known (18%). Approximately 60% of the subjects knew about the exposure dose increasing cancer mortality (63%) and the 5‐year lens REX limit (56%).

Conclusions

There was some improvement in radiation protection equipment or education, but relatively little compared to the 2020 survey of endoscopy departments.
Generation of floxed Spag6l mice and disruption of the gene by crossing to a Hprt‐Cre line
Authors: Man Yonghong , Li Wei , Yap Yi Tian , Kearney Alivia , Yee Siu‐Pok , Strauss Jerome F. , Harding Pamela , Song Shizheng , Zhang Ling , Zhang Zhibing
Published: April 2023

Mouse sperm‐associated antigen 6 like (SPAG6L) is an axoneme central apparatus protein, essential for the normal function of the ependymal cell and lung cilia, and sperm flagella. Accumulated evidence has disclosed multiple biological functions of SPAG6L, including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Conventional Spag6l knockout mice died of hydrocephalus, which impedes further investigation of the function of the gene in vivo. To overcome the limitation of the short lifespan of conventional knockout mice, we developed a conditional allele by inserting two loxP sites in the genome flanking exon 3 of the Spag6l gene. By crossing the floxed Spag6l mice to a Hrpt‐Cre line which expresses Cre recombinase ubiquitously in vivo, mutant mice that are missing SPAG6L globally were obtained. Homozygous mutant Spag6l mice showed normal appearance within the first week after birth, but reduced body size was observed after 1 week, and all developed hydrocephalus and died within 4 weeks of age. The phenotype mirrored that of the conventional Spag6l knockout mice. The newly established floxed Spag6l model provides a powerful tool to further investigate the role of the Spag6l gene in individual cell types and tissues.
Multi‐hazard fragility assessment of monopile offshore wind turbines under earthquake, wind and wave loads
Authors: Zhang Ziliang , De Risi Raffaele , Sextos Anastasios
Published: April 2023

This study establishes a multi‐hazard probabilistic assessment framework for assessing the integrity of monopile offshore wind turbines (OWT) under the stochastic coupled effect of wind, wave and earthquake loading. The procedure deals with the entire operational range of inflow wind speed (i.e., 3–25 m/s), for which the probability of failure under multi‐hazard excitations is found to be non‐negligible. Numerical analysis is performed by implementing nonlinear finite‐element models of the OWT developed in OpenSees. The dynamic response of the OWT system under wind‐ and wave‐load combinations is individually validated against those obtained from the aero‐hydro‐servo‐elastic simulator OpenFAST. Following the Latin‐hypercube approach, a cloud‐based assessment procedure is then performed with an ensemble of 300 earthquake ground motions, from which the multi‐hazard performance of the OWT regarding the serviceability limit state (SLS) and the ultimate limit state (ULS) can be evaluated. The epistemic uncertainty associated with various loads, structural properties, and soil conditions is also accounted for. Based on this probabilistic assessment framework, the sensitivity of the resulting OWT fragility surfaces to different statistical regression methods and wind—ground motion intensity measure pairs (IM‐pairs) is further scrutinised. Regression methods are comparatively evaluated. The efficiency, practicality, proficiency and sufficiency of various IM‐pairs are examined for the purpose of assessing operating OWT multi‐hazard fragility functions. The optimum IM‐pair is then employed in a trained Gaussian Process Regression (GPR) scheme for cloud data regression to assess the multi‐hazard fragility of the system. The derived multi‐hazard fragility function shows that the contribution of seismic forces in structural demand for a design‐level earthquake is comparable to those caused by operational‐level wind and wave loads.
Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma—diagnostic challenge and report of two cases
Authors: Carrillo‐Ng Hugo , Liang Yu , Chang Sue , Afkhami Michelle , Gernon Thomas , Bell Diana , Arias‐Stella Javier A.
Published: April 2023

Rhabdomyosarcomas (RMS) are malignant mesenchymal tumors with skeletal muscle differentiation which are classified into alveolar, embryonal, pleomorphic, and spindle cell/sclerosing RMS. Within the spindle cell/sclerosing RMS tumor type there is a recently recognized sub‐type categorized as intraosseous spindle cell RMS with TFCP2/NCOA2 gene fusion. This rare tumor is highly aggressive with predominant involvement of the craniofacial and pelvic bones with approximately 30 cases reported to date. Histopathologic features include spindle cell and epithelioid morphology with a characteristic co‐expression of epithelial markers, myogenic markers, and ALK1 expression. We report two cases of gnathic spindle cell/sclerosing RMS with FUS::TFCP2 gene fusion that were initially interpreted as carcinomas by referring institutions and later reclassified when encountered in our practice after additional work‐up and molecular characterization.
RETRACTED: Optimization of renewable energy supply for a carbon neutral society: Role of environmental regulations, sustainable finance, and financial innovation through the lens of game theory
Authors: Najam Hina
Published: April 2023

Nations maximize green technologies and renewable energy to address climate change and reach sustainable development goals. As a result of the Paris Climate Agreement, several countries have made reducing or eliminating their carbon footprints a primary priority. Using a game theoretical perspective, this article analyses empirical data from 2011 to 2021 to determine the impact that renewable energy, environmental regulation, sustainable finance, and financial innovation will have on the ability to emerge from Asian nations in order to achieve a carbon‐neutral society. The cross‐section dependence, panel unit root, and augmented mean group tests confirmed the zero‐carbon environmental Kuznets curve hypothesis. As a result, it is observed that the availability of renewable energy, environmental regulations, sustainable finance, and financial innovation greatly cut carbon emissions and boosts national capabilities to reach the carbon neutrality target. The reduction of sectoral risks and carbon emissions, as well as achieving a sustainable and carbon‐neutral society. It would be facilitated by nations capitalizing on and reinforcing these variables and expanding investment in green recovery.
Valuation of cryptoassets in EU insolvency: Challenges and prospects
Authors: Kostoula Theodora
Published: April 2023

How and when to determine the value of cryptoassets in insolvency proceedings? This question becomes more topical with the increasing adoption of volatile cryptoassets such as Bitcoin. As many of these assets do not have an ‘apparent’ value that may be readily ascertainable, it is not always clear how their value may be established. This presents significant challenges to their proper valuation in the context of insolvency proceedings and requires certain attention to efficiently confront the implications on the assessment of claims, the calculation of their value and the determination of the recoverable amount. Accordingly, this Article exposes the arising challenges and implications from an EU insolvency perspective, with the aim to trigger considerations for legislative interventions at EU level.
SENSITIVITY OF A HEALTH STATUS MEASURE TO SHORT‐TERM CLINICAL CHANGES IN ARTHRITIS
Authors: Anderson Jennifer J. , Firschein Hill E. , Meenan Robert F.
Published: April 2023

To assess the sensitivity of the Arthritis Impact Measurement Scales (AIMS), we analyzed data from 3 clinical trials. One trial involving 255 patients with rheumatoid arthritis (RA) was a 12‐week, randomized controlled trial of diclofenac, naproxen, and aspirin. Two trials were open‐label studies of 24 weeks duration that included 165 RA and 355 osteoarthritis (OA) patients, all of whom were treated with diclofenac. In addition to the AIMS, tender joint count, morning stiffness, and erythrocyte sedimentation rate were used as outcome measures in the trials. The AIMS results showed substantial improvements in Physical Function, Psychological Status, and Pain, as well as in overall Arthritis Impact. These improvements were detected by the time of the initial outcome assessment at 4 weeks or 8 weeks, and were detected in patients with either OA or RA. These AIMS results closely parallel improvements shown by traditional clinical measures, and demonstrate that the AIMS health status measure is sensitive to improvements in OA as well as in RA. The AIMS also detects responses produced by therapy with nonsteroidal antiinflammatory drugs (NSAIDs), and these improvements can be demonstrated in as short a treatment time as 4 weeks. These findings confirm the utility of the AIMS for assessing outcome in rheumatic disease studies, and they have implications for the design of future clinical trials of NSAIDs.
Revisiting the impact of ASC 280: Liquidity, operating performance, and market value
Authors: Chuwonganant Chairat , Olibe Kingsley O. , Strawser Jeffrey W. , Strawser William R.
Published: April 2023

The Financial Accounting Standards Board (FASB) enacted Statement of Financial Accounting Standards No. 131 (now Accounting Standards Codification 280) to improve the valuation of firms’ future growth opportunities through changes to segment disclosures. Prior research on foreign investment relies primarily on levels analyses. Using both changes and levels analyses, we provide evidence that investments in foreign fixed assets by US firms is significantly and positively related to operating income and net cash flows from operations. Foreign fixed assets are also significantly and positively related to stock prices, returns, and stock liquidity. Generally, our results suggest that increases in international diversification are related to increased operating performance and liquidity, while our price and returns results suggest that investors incorporate geographic asset data in their valuation models.
sCXCL16 as a prognostic biomarker for COVID‐19 outcome
Authors: Boukhalfa Yasmine , Stambouli Nejla , Driss Adel , Daiki Maissa , Abouda Amal , Razgallah Rabie , Gharsallah Hedi , Sellami Walid , Abid Rym , Hannachi Souha , Battikh Riadh , Benmoussa Mohamed , Mazigh Chakib , Ferjani Mustapha , Elgaaied Amel B. , Labbene Iheb
Published: April 2023

As elevated levels of the soluble CXCL16 (sCXCL16) chemokine have been reported in severe coronavirus disease 2019 (COVID‐19) patients, this study examined whether sCXCL16 concentration on the first day of hospitalization predicted death in COVID‐19 patients. A total of 76 patients with COVID‐19 were admitted to the Military Hospital of Tunis, Tunisia, between October 2020 and April 2021, and later classified as survivors or nonsurvivors based on their outcomes. At admission, the groups were matched by age, gender, comorbidities, and the percentage of patients with moderate conditions. On the first day of admission, serum's sCXCL16 concentrations were measured using a magnetic‐bead assay. There was an eightfold increase in serum sCXCL16 levels in the nonsurvivors’ group (3661.51 ± 2464.87 pg/mL vs. 454.3 ± 338.07 pg/mL, p < 0.0001). For the optimal cutoff value of sCXCL16 at 2095 pg/mL, we found a 94.6% sensitivity and a 97.4% specificity, with an area under curve of 0.981 (p = 5.03E−08; 95% confidence interval [95% CI]: 0.951–1.0114). Considering the risk of death at a concentration above the threshold, the unadjusted odds ratio was 36 (p < 0.0001). The adjusted odd ratio was estimated at 1.003 (p < 0.0001; 95% CI: 1.002–1.004). Finally, there was a significant difference between survival and nonsurvival groups in leukocyte numbers (p = 0.006), lymphocytes (p = 0.001), polymorphonuclear neutrophils (p = 0.001), and C‐reactive protein levels (p = 0.007), except for monocytes (p = 0.881). Based on these results, sCXCL16 level could be used for detecting nonsurvival COVID‐19 patients. Therefore, we recommend assessing this marker in hospitalized COVID‐19 patients.
Learning from an equitable, data‐informed response to COVID‐19: Translating knowledge into future action and preparation
Authors: Stanzler Morgen , Figueroa Johanna , Beck Andrew F. , McPherson Marianne E. , Miff Steve , Penix Heidi , Little Jessica , Sampath Bhargavi , Barker Pierre , Hartley David M.
Published: April 2023

Introduction

The COVID‐19 pandemic revealed numerous barriers to effectively managing public health crises, including difficulties in using publicly available, community‐level data to create learning systems in support of local public health decision responses. Early in the COVID‐19 pandemic, a group of health care partners began meeting to learn from their collective experiences. We identified key tools and processes for using data and learning system structures to drive equitable public health decision making throughout different phases of the pandemic.

Methods

In fall of 2021, the team developed an initial theory of change directed at achieving herd immunity for COVID‐19. The theoretical drivers were explored qualitatively through a series of nine 45‐min telephonic interviews conducted with 16 public health and community leaders across the United States. Interview responses were analyzed into key themes to inform potential future practices, tools, and systems. In addition to the interviews, partners in Dallas and Cincinnati reflected on their own COVID‐19 experiences.

Results

Interview responses fell broadly into four themes that contribute to effective, community driven responses to COVID‐19: real‐time, accessible data that are mindful of the tension between community transparency and individual privacy; a continued fostering of public trust; adaptable infrastructures and systems; and creating cohesive community coalitions with shared alignment and goals. These themes and partner experiences helped us revise our preliminary theory of change around the importance of community collaboration and trust building and also helped refine the development of the Community Protection Dashboard tool.

Conclusions

There was broad agreement amongst public health and community leaders about the key elements of the data and learning systems required to manage public health responses to COVID‐19. These findings may be informative for guiding the use of data and learning in the management of future public health crises or population health initiatives.
Construction of an Antithrombotic and Anti‐Inflammatory Polyethersulfone Membrane
Authors: Fu Xiao , Lei Ting , Tang Ci , Peng Jie
Published: April 2023

In addition to being the core factor in thrombosis, thrombin is involved in various inflammatory disease responses, but few studies have examined whether and how it is involved in membrane‐related inflammation. In this study, the thrombin inhibitor dabigatran is used to modify a polyethersulfone dialysis membrane. The modified membrane shows good hydrophilic properties and dialysis performance. It reduces the thrombin level in a targeted manner, thereby significantly inhibiting coagulation factor activation (based on the prothrombin time, international normalized ratio, activated partial thromboplastin time and thrombin time) and reducing the fibrinogen level and platelet adhesion. On thromboelastography, it shows excellent dynamic antithrombotic capacity. The modified membrane inhibited membrane‐related inflammation by inhibiting the production of the inflammatory mediators C‐reactive protein (CRP), interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β) via the thrombin/complement C5a pathway. Moreover, it is found to be safe in an in vivo study. Thus, the dabigatran‐modified polyethersulfone membrane may reduce dialysis‐related complications through its dual antithrombotic and anti‐inflammatory effects.
Enhanced nuclear translation is associated with proliferation and progression across multiple cancers
Authors: Zou Sailan , Kim Byung‐Wook , Tian Yan , Liu Geng , Zhang Jiawei , Zerda Ricardo , Li Zhuo , Zhang Guixiang , Du Xiao , Lin Weiqiang , Gao Xiang , Huang Wendong , Fu Xianghui
Published: April 2023

Recent technological advances have re‐invigorated the interest in nuclear translation (NT), but the underlying mechanisms and functional implications of NT remain unknown. Here we show that NT is enhanced in malignant cancer cells and is associated with rapid cell growth. Nuclear ribopuromycylation analyses in a panel of diverse cell lines revealed that NT is scarce in normal immortalized cells, but is ubiquitous and robust in malignant cancer cells. Moreover, NT occurs in the nucleolus and requires normal nucleolar function. Intriguingly, NT is reduced by cellular stresses and anti‐tumor agents and positively correlates with cancer cell proliferation and growth. By using a modified puromycin‐associated nascent chain proteomics, we further identified numerous oncoproteins that are preferentially translated in the nucleus, such as transforming growth factor‐beta 2 (TGFB2) and nucleophosmin 1 (NMP1). Specific overexpression of TGFB2 and NMP1 messenger RNAs in the nucleus can increase their protein levels and promote tumorigenesis. These findings establish a previously unknown link between NT and malignancy and suggest that cancer cells might have adapted a mechanism of NT to support their need for rapid growth, which highlight the potential of NT in tumorigenesis and might also open up new possibilities for therapeutic targeting of cancer‐specific cellular functions.
Upper tropospheric cloud‐radiation interaction induced by monsoon surge over the South China Sea
Authors: Koseki Shunya , Fonseca Ricardo , Koh Tieh‐Yong , Teo Chee‐Kiat
Published: April 2023

We have investigated cloud formation over the South China Sea in the upper troposphere and its impacts on the radiation budget of the troposphere and ocean surface under monsoon surges using satellite and reanalysis products and an atmospheric numerical model. During strong surges (SS), the upper tropospheric (UT) cloud formation in central South China Sea shows a clear diurnal cycle, peaking around 12–14 local solar time when the incoming solar radiation is the strongest. The enhanced UT clouds attenuate the incoming solar radiation in the upper troposphere reducing the net downward shortwave radiation flux at the surface by approximately 28% in SS compared with no surge case. In contrast the downward longwave radiation flux is enhanced mainly from the middle to upper troposphere in SS. The cooling because of the diminished incoming shortwave radiation overwhelms the warming due to the longwave radiation at the ocean surface. This cloud radiative forcing is observed partly over the cold tongue in sea surface temperature (SST) in the South China Sea. Numerical simulations with a 1‐dimensional slab ocean model suggests that the monsoon‐induced UT cloud radiative forcing contributes partially to maintain and reinforce the SST cold tongue with a tendency of about 0.08 K in 6 days or about 1/6 of one standard deviation of the Cold Tongue Index in December. The latent heat flux due to the monsoon surge is still the most significant factor maintaining the cold tongue.
Mounting anti‐LGBTQ+ bills impact mental health of youths
Authors: Canady Valerie A.
Published: April 2023

The influx of anti‐LGBTQ+ legislation proposed by states in recent years, and in particular in 2023 around the country, continues to take a toll on the mental health of our country's youth population, including increases in stress and anxiety, according to national polls and news outlets.
Initiative boosts preventive MH support for NYC students
Authors: Canady Valerie A.
Published: April 2023

Observing the shortage of child and adolescent psychiatrists in New York City, an online wellness platform with its team of educators, mental health practitioners and parents is working to provide students with one‐on‐one student coaching and holistic wellness check‐ins.
Treatment‐resistant depression begs for innovation
Authors: Benabou Reina
Published: April 2023

Major depressive disorder (MDD) is a leading cause of disability in the United States, and an estimated one‐third of the 21 million American adults living with MDD have treatment‐resistant depression (TRD), diagnosed when patients do not respond to two different antidepressants of adequate dose and duration. This creates significant, ongoing burden — emotional, functional and economic — on the individual, their loved ones and society that cannot be overstated.
Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High‐Fat Diet through Regulating the Glycolytic Pathway
Authors: Luo Min , Zhuge Xiuhong , Ji Lin , Wang Jinyuan , Mo Yi , Tan Yongpeng , Zhou Leguang , Lei Xiaocan , Huang Hua
Published: April 2023

Scope

Obesity is a global threat for male infertility, which can cause spermatogenic dysfunction. However, there are no available drugs for the treatment of obesity‐induced spermatogenesis dysfunction. This study characterizes the protective effects of icariin (ICA) on spermatogenesis dysfunction in obese mice.

Methods and results

Obese mice are induced by a high‐fat diet to determine whether ICA has a protective effect. ICA treatment reduces body weight and the proportion of abnormal sperm, brings about a recovery of sperm count, and the number of spermatogenic cells. ICA treatment improves histopathological changes of the testes and inhibits testicular apoptosis, as evidenced by reduced the expression of Bax and increased the expression of Bcl‐2, PCNA, WT1, GATA‐4, vimentin, HK2, PKM2, and LDHA in the testes. In vitro, TM4 cells are treated with 0.4 mm palmitic acid (PA) to induce Sertoli cell injury, and are then utilized for ICA treatment. ICA improves PA‐induced decreased TM4 cells viability, reduces the levels of lactate, and increases the levels of pyruvate and the expression of HK2, PKM2, and LDHA and restores the glycolytic process in vitro.

Conclusion

ICA ameliorates spermatogenic dysfunction in obese mice by regulating glycolytic activity, providing effective strategies for obesity treatment.
Variations of the in‐situ stress within nonhomogeneous layers of the subsurface rock induced by changes in pore fluid pressure
Authors: Su Xing , Mehrabian Amin
Published: April 2023

This paper presents a three‐dimensional analytical solution for deformation and stress change inside and outside a porous layer of rock subjected to prescribed axisymmetric disturbance in the pore fluid pressure. The porous layer is confined between two impermeable layers of rock. Different mechanical moduli are considered for the porous and confining strata. The solution is derived from Navier's equations of static equilibrium while considering the continuity of stress and deformation across the rock layers which are assumed to follow linearly poroelastic constitutive behavior. Results for the case of uniform pore fluid pressure change within the porous layer are demonstrated in terms of rock deformation, as well as changes in the magnitude and orientation of principal stresses, inside and outside the porous layer. Variations of these results with key problem parameters including the stiffness ratio of rock layers and the aspect ratio of disturbed pore pressure volume are presented. Findings indicate the large effect of layers heterogeneity on redistribution and reorientation of the in‐situ stress, yet, less significantly on deformation of the porous layer. Results further reveal the substantial error rates that uniaxial strain models may produce in estimating the stress path of depleted or injected reservoirs.