bluuebunny/crossref_metadata_2025 huggingface dataset:
INTRODUCTION TO BIOPHARMACEUTICS
Authors: Kaur Navneet , Nepal Rajip , Singh Surg Lt Cdr (Dr) Prabhjot
Published: May 2024

Biopharmaceutics is the relationship among drug’s all properties like organolaptic properties, hydrolysis, oxidation, reduction, racemization etc, and its dosage formulation, also administration route. The sequence of events that predict elicitation, therapeutic effect of drug are important as a drug in its form and formulation of drug on the absorption and distribution to the target site. Initially the drug is absorbed orally or by any other route followed by release in predictable manner after that some portion of drug reaches to surrounding tissues finally reaches to the target site. Now we get required pharmacological response after achievement of minimum effective concentration by a drug product. Biopharmaceutics consideration often determines the proper potency of formulation like local action drugs i.e. an ointment when apply topically, characterized as percentage or concentration of active ingredients of that preparation. But tablet form is always denoted in milligrams, now this dose depends upon the systemically absorbed quantity of drug when mixed with the proper quantity for getting required amount
EVIDENCED BASED PRACTICE IN INTENSIVE CARE UNIT
Authors: Mohapatra Bishnupriya
Published: May 2024

By using current knowledge and best evidence practices to make decisions about how to care the critically ill patients to get the best outcomes. In ICU where patients are suffering from life threatening conditions so the fully dependent upon highly advanced equipment and the medications. ICU should highly organized and designed in such a way to meet all the needs of the patients. Having skilled personnel with following evidenced based practices to promote the delivery of patient care, cost-effective, enhancing patient and family satisfaction with professional development
SUSTAINABILITY IN HEALTH AND HEALTH CARE PROVISIONS
Authors: Rathore Harsha , Mishra Ravindra , Bhargava Sarvesh , Dhakad Krati , Solanki Nitin
Published: May 2024

As health care systems face huge challenges, sustainability is seen as an important demand for creating them appropriate the long run. However, there's no accord with relation to either the definition of the term or the factors that characterize a ―sustainable health care system‖. Therefore, the aim of this text is twofold. First, is to provide samples of the prevailing literature regarding sustainable health care system and analysing this literature with relation to its understanding of sustainability regarding the strength and weaknesses of the various approaches. The work then identifies crucial factors for sustainable health care systems, and also resulting the sustainable healthcare system is the need of future development of our health and needful work in the field of healthcare an abstract framework consisting of 5 distinct and interacting factors, will be seen as a place to begin for any analysis. Improving the sustainability health services is an opportunity to improving the safety and quality of care, improve the health of the community
REGULATORY STRATEGY FOR PRODUCT DEVELOPMENT AND LIFE CYCLE MANAGEMENT: A REVIEW
Authors: Patel Vaishali , Chaudhari Rajashri , Patel Pratima , Parmar Kinjal
Published: May 2024

More effective drug development and manufacture are required due to the complexity of the pharmaceutical market today. Even in this extremely complicated environment, Product Lifecycle Management (PLM) offers the potential to increase the effectiveness and reduce the risk of pharmaceutical production.[1] From an initial idea to the final retreat, the product lifecycle management develops and oversees a company's product-related intellectual capital. It helps the pharmaceutical sector by extending the life of patents and improving pricing tactics.[2] Among the key applications of product lifecycle management are increased patient compliance, revenue growth, extended clinical benefits, cost advantages, life extension exclusivity, and quicker market launch.[3] Less difficulties, lower costs, higher yields, personnel equipped to make wise decisions, and audits that make everyone more accountable are all advantages that leaders are actively pursuing through the implementation of PLM
A NOVEL DRUG DELIVERY OF LIPOSOMES: A COMPREHENSIVE REVIEW
Authors: U. V Miruthula. , S Muthukumar.
Published: May 2024

Liposomes are little spherical artificial vesicles, which is made up of naturally derived phospholipids or pure surfactants. The components of liposomes are Phospholipids, Cholesterol and other additional excipients. Liposomes was like vesicular in structures consisting of hydrated bilayers. Liposomes are classified into different types like., Based on their structural components, based on method of liposome preparation, based on composition and applications etc. The pharmacokinetics of liposomes focused on the total body fluids and tissue distribution and their metabolism. Liposomal based formulation is implemented in the clinical fields. Doxil was the anticancer liposome which was first approved liposome
Peran dan Tantangan Tenaga Pendidik dalam Menghadapi Kurikulum Merdeka di SMP Negeri 2 Sipoholon
Authors: Sipahutar Sonia Widia , Gita Sonya Sagala  , Enjelina Aruan  , Renimawati Gea
Published: May 2024

The role and challenges faced by teaching staff in implementing the independent curriculum at Sipoholon State Middle School. In the learning process using the independent curriculum, teaching staff at SMP Negeri 2 Sipoholon have challenges, including: making clear and flexible schedules for teachers, holding regular training and workshops, forming teams or working groups of teachers, and encouraging active participation of students in the learning process. Solutions to face these challenges include increasing supervision and support from schools, regular training and workshops, as well as providing ongoing professional training and development. In this way, educators are expected to be able to overcome these challenges and improve student performance significantly. This research was conducted using qualitative methods, namely field observations and interviews. The results of the research show that the implementation of the independent curriculum at SMP Negeri 2 Sipoholon. The results of the research show that the implementation of the independent curriculum is less effective at SMP Negeri 2 Sipoholon because it causes many problems. The aim of this research is to identify the roles and challenges faced by teaching staff in implementing the independent curriculum at SMP Negeri 2 Sipoholon and to develop effective solutions to overcome these challenges. This research aims to provide an in-depth understanding of the important role of teaching staff in designing and implementing an independent curriculum, as well as to identify concrete obstacles that may hinder effective implementation.
Localized Urinary Bladder Amyloidosis as Urothelial Cancer Mimicker: A Case Series Examining Cystoscopic, Histologic, and Cytologic Findings
Authors: Regmi Aayushma , Mehta Maitri , Farooq Ahmer V. , Turk Thomas M. , Wojcik Eva M. , Picken Maria M.
Published: May 2024

Context.—

Localized amyloidosis of the bladder is rare and often mimics bladder malignancy. It is typically associated with the extracellular deposition of monoclonal light chains, either κ or λ. The cause is unknown, but it is thought to be due to chronic inflammation/cystitis.

Objective.—

To highlight the importance of localized urinary bladder amyloidosis as a rare mimicker of urothelial malignancy and elucidate its clinical, histopathologic, and cytopathologic manifestations.

Design.—

Cases of urinary bladder amyloidosis diagnosed during 2000–2023 were retrieved retrospectively from pathology archives. Electronic medical records, including cystoscopy findings and pathology slides including Congo red stain, were reviewed.

Results.—

Here we present 6 patients with localized urinary bladder amyloidosis. Four of the 6 patients were women, with ages ranging from 46 to 69 years, and a mean age of 58 years. Five of 6 patients presented with hematuria, while in 1 patient, bladder amyloidosis was discovered incidentally. Cystoscopy findings invariably were concerning for malignancy, with raised erythema in 5 patients and fungating mass protruding into the bladder lumen in 1 patient. Bladder biopsies and urine cytology were negative for malignancy in all cases. Congo red–positive amyloid deposits involved lamina propria with sparing of the detrusor muscle. In 5 cases, the deposits were typed as derived from the λ light chain, whereas no information was available for 1 patient. Subsequent clinical workup ruled out systemic amyloidosis.

Conclusions.—

These cases of urinary bladder amyloidosis highlight the importance of considering rare amyloidosis in the differential diagnosis of hematuria and cystoscopy with a lesion mimicking malignancy.
Youth`s psychosocial characteristics in agriculture: The case of Bukidnon, Philippines
Authors: Quijano-Pagutayao Anecil
Published: May 2024

The study sought to analyze the youth`s psychosocial characteristics in Agriculture in Bukidnon, Philippines. Specifically, this study aimed to describe the socio-demographic characteristics of the senior high school students; assess the   knowledge of the students in agriculture; determine the student’s attitude towards agriculture and to identify the student’s motivation towards agriculture as a degree program. Data were gathered through guided interview/survey that was personally administered to 383 respondents who were in Grade 12 senior high school students in the DepEd, District of Bukidnon. Focus group discussion and key informant interview were also used in the study. Descriptive statistical tools such as mean, rank, percentage, and frequency counts were employed. Findings of the study reveal that the respondents of the study are mostly female, and have experiences in farming.  Their parents have moderate level of education. More than half of the respondents’ families do not own a piece of land used in agriculture.  They are willing to engage in agriculture but are not willing to enroll in an agriculture degree. These youth have low level of knowledge and skills in agriculture and have favorable attitude and positive motivation towards a degree.
Knowledge Management Maturity Model of Higher Education Based-on Quality Culture and Human Resource Management Practices
Authors: Herminingsih Anik , Ratnasari Srilanggeng
Published: May 2024

There are 2 main important things to improve knowledge management maturity (KMM), namely organizational culture and proper HR management. There are no studies on human resource culture and management that are specific to increasing KMM in tertiary institutions. Empirical research on the influence of higher education quality culture as a goal of implementing the Internal Quality Assurance System (SPMI) on all tertiary institutions in Indonesia and the influence of HR management on KMM is still very limited. This study aims to develop a model for improving KMM in Indonesian universities through the implementation of a quality culture and human resource management. The analysis was carried out with a structural equation model (SEM). The results showed that quality culture had a positive and significant effect on human resource management practices, but had no direct effect on knowledge management maturity. Human resource management practices have a positive and significant effect on knowledge management maturity. The results of this study prove the importance of the quality culture of higher education in developing mature knowledge management, through human resource management practices.
KONSEP HUKUM ISLAM MENGENAI PERNIKAHAN SIRI DI INDONESIA DAN IMPLIKASI HUKUM
Authors: Sepyah Sepyah , Hardiyatullah Hardiyatullah , Nuriskandar Lalu Hendri , Jayadi Nurman
Published: May 2024

Konsep hukum Islam mengenai pernikahan siri berakar pada nash-nash al-Quran dan hadis yang memberikan landasan bagi praktik ini. Dalam pandangan Islam, perkawinan siri dapat sah jika memenuhi syarat-syarat tertentu, meskipun hal ini seringkali bertentangan dengan hukum positif di Indonesia yang mengatur perkawinan secara resmi. Di Indonesia, perkawinan siri seringkali terjadi di luar kontrol hukum negara dan tidak diakui secara resmi. Implikasi hukum dari praktik ini mencakup status hukum anak, hak-hak waris, dan kewajiban-kewajiban finansial antara pasangan. Sementara itu, secara sosial, perkawinan siri dapat menimbulkan stigmatisasi terhadap perempuan yang terlibat serta menimbulkan ketidakstabilan dalam struktur keluarga. Dalam menangani perkawinan siri, diperlukan pendekatan yang holistik yang melibatkan kerjasama antara institusi agama, lembaga hukum, dan masyarakat sipil. Pendidikan dan peningkatan kesadaran masyarakat tentang konsekuensi hukum dan sosial dari perkawinan siri menjadi kunci untuk mengurangi praktik ini. Penelitian ini menggunakan metode analisis literatur tentang konsep hukum Islam mengenai perkawinan siri di Indonesia dan implikasinya. Diharapkan artikel ini dapat menjadi kontribusi dalam pemahaman lebih lanjut tentang masalah yang kompleks ini serta mendorong diskusi dan tindakan yang lebih luas untuk menangani perkawinan siri dengan bijaksanaan dan adil.
DINAMIKA POLITIK IDENTITAS DAN DINASTI DI INDONESIA: Menuju Politik yang Ideal Melalui Eksplorasi Teori Maslahah
Authors: Sugitanata Arif , Hamdi Muh. Rizal , Nuriskandar Lalu Hendri , Jayadi Nurman
Published: May 2024

This research aims to explore the dynamics of identity politics and dynasties in Indonesia and efforts to present ideal politics. This study uses a literature review, adopts a qualitative research approach, and applies descriptive analysis techniques based on Maslahah's theory. The results show that identity politics and dynasties play a significant role in the formation of power, often relying on ethnic, religious, or family identity to mobilise support, which can increase the representation of certain groups but also trigger polarisation and erode the principles of democracy and meritocracy. The interaction between identity politics and dynasties creates complexities in political dynamics that can hinder the achievement of an ideal politics based on democracy, justice and equality. On the other hand, efforts towards ideal politics in Indonesia must involve a strong commitment to the principles of democracy, justice and equality, strengthening the foundations of inclusive and participatory democracy, ensuring free and fair elections, and building political awareness and political education among the people. Eradicating corruption, collusion, and nepotism is also a top priority in creating clean politics and integrity. In addition, nurturing diversity and pluralism is an essential step in creating a more inclusive and democratic society. A Maslahah theory-based analysis also emphasises the achievement of the common good and the prevention of harm, which are essential in guiding Indonesia towards ideal politics. It includes empowering individuals and groups in society, promoting social justice, and maintaining social harmony. As such, this study makes an essential contribution to the understanding of identity and dynastic politics in Indonesia and the steps needed to achieve a more equitable and inclusive politics.
TINJAUAN HUKUM ISLAM TERHADAP SANKSI PIDANA PENCABULAN YANG DILAKUKAN OLEH ANAK DIBAWAH UMUR MENURUT UNDANG-UNDANG NOMOR 35 TAHUN 2014
Authors: Karuniawan Fathony , Adnan Idul , Nuriskandar Lalu Hendri
Published: May 2024

Children who violate the law or commit criminal acts are greatly influenced by several other factors outside the child, such as relationships, education, playmates and so on. Because criminal acts committed by children are generally a process of imitating anything influenced by negative actions from adults or those around them. What factors influence the occurrence of criminal acts of sexual immorality committed by minors, internal factors, namely intelligence factors, age factors, gender factors, while external factors, namely household factors, educational and school factors, children's social factors and social media factors in resolving criminal acts of obscenity. committed by minors and criminal sanctions for perpetrators of sexual abuse against children according to Law Number 35 of 2014 can be implemented by the Panel of Judges by applying Article 82 of Law Number 35 of 2014 and Article 290 paragraph 2 of the Criminal Code, if the defendant is proven to fulfill the objective and critical elements. subjective nature contained in these two articles carries a maximum penalty of 15 years in prison and a minimum of 3 years in prison. According to the view of Islamic law, the implementation of criminal sanctions against perpetrators of sexual abuse against children can be applied ta'zir,
A variation of Lp local uncertainty principles for Weinstein transform
Authors:   Northern Border University, College of Science, Department of Mathematics, Arar, Saudi Arabia, SAOUDI Ahmed , KALLEL Imen ,   Northern Border University, College of Science, Department of Mathematics, Arar, Saudi Arabia
Published: May 2024

The main crux of this paper is to introduce $L^p$ local uncertainty inequalities for the Weinstein transform, and we study $L^p$ version of the Heisenberg-Pauli-Weyl uncertainty inequalities for this transform. Then, by using the $L^p$ local uncertainty inequalities for the Weinstein transform and the tools of Donoho-Stark, we obtain uncertainty principles of concentration in the $L^p$ theory, for all $1 p \leq 2$.
Some remarks on the magnetic field operators \nabla±iA and its applications
Authors:   Yunnan University, School of Mathematics and Statistics, Kunming, 650500, Yunnan, P. R. China, WANG Wenbo
Published: May 2024

In the present paper, we give some remarks on the magnetic field operators $\nabla \pm iA$. As its applications, we study the Schr\"{o}dinger equation with a magnetic field
\begin{equation*} -\Delta u+|A(x)|^{2}u+iA(x)\cdot \nabla u=\mu u+|u|^{p}u,~x\in \mathbb{R}^{N}, \end{equation*}
where $u$ is a complex-valued function and $\mu\in \mathbb{R}$. When $N>2$, for $2 p+2 \frac{2N}{N-2}$ or $N=2$, for $2 p+2 +\infty$, the existence and nonexistence of minimizers of the corresponding minimization problem are given via constrained variational methods. As a by-product, the above equation admits a normalized solution. We point out that the condition ${div}A(x)=0$ plays a crucial role in our study.
Finite groups in which every non-nilpotent maximal invariant subgroup of order divisible by p is a TI-subgroup
Authors:   Yantai University, School of Mathematics and Information Sciences, Yantai 264005, P.R. China, XU Fanjie , SHI Jiangtao ,   Yantai University, School of Mathematics and Information Sciences, Yantai 264005, P.R. China, SHAN Mengjiao ,   Yantai University, School of Mathematics and Information Sciences, Yantai 264005, P.R. China
Published: May 2024

Let A and G be finite groups such that A acts coprimely on G by automorphisms. We obtain a complete description of the structure of finite groups in which every non-nilpotent maximal A-invariant subgroup of order divisible by p is a TI-subgroup for any fixed prime divisor p of the order of groups.
Path and trajectory planning of a RPRPR planar parallel robot for prevention of high-order singularities
Authors:   Marmara University, Faculty of Engineering, Department of Mechanical Engineering, Recep Tayyip Erdoğan Campus, 34854 Maltepe, İstanbul, Türkiye, ÖZDEMİR Mustafa , KARAKAYA Levent ,   Marmara University, Institute of Pure and Applied Sciences, Department of Mechanical Engineering (English), Göztepe Campus, 34722 Kadıköy, İstanbul, Türkiye
Published: May 2024

Parallel robots have many remarkable advantages over their conventional serial counterparts. Highly accurate positioning capability and high payload-to-weight ratio are among the main ones. The main factor underlying all these advantages is their closed-loop construction. However, this constructional feature also causes a special singularity problem, which constitutes their biggest disadvantage. Characteristic singularities classified as Type II exist inside their workspace, around which the magnitude of the inverse dynamic solution grows unboundedly. This naturally yields the saturation of the actuators and eventually in uncontrollability of the robot. Consequently, the whole workspace becomes impossible to be used. In order to pass through a Type II singularity, the consistency of the motion equations of the robot must be maintained at that singularity. However, any Type II singular configuration can transform into a high-order singularity, which, in order to be passed through, requires additional conditions other than the consistency. Therefore, full utilization of the whole workspace with a minimum number of conditions requires to avoid high-order singularities. The present article contributes to the literature by developing path and trajectory planning principles for preventing a two-degree-of-freedom planar parallel robot with RPRPR structure from experiencing high-order singularities.
Fisher Information and Shannon’s Entropy for Record Values and Their Concomitants under Iterated FGM Family
Authors:   1. Department of Mathematics and Statistics, Faculty of Science,
Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia
2. Department of Mathematics, Faculty of Science, Benha University, Benha 13518, Egypt, ABD ELGAWAD M. A. , BARAKAT H. M. ,   Department of Mathematics, Faculty of Science, Zagazig University, Zagazig 44519, Egypt, ABDELWAHAB M. M. ,   1. Department of Mathematics and Statistics, Faculty of Science,
Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia
2. Department of Mathematics, Faculty of Science, Benha University, Benha 13518, Egypt, ZAKY M. A. ,   Department of Mathematics and Statistics, Faculty of Science,
Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia, HUSSEINY I. A. ,   Department of Mathematics, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
Published: May 2024

Let {(Xi ,Yi), i ≥ 1} be independent and identically distributed random variables (RVs) from a continuous bivariate distribution. If {Rn,n ≥ 1} is the sequence of upper record values in the sequence {Xi}, then the RV Yi, which corresponds to Rn is called the concomitant of the nth record, denoted by R[n]. We study the Shannon entropy (SHANE) of R[n] and (Rn,R[n]) under iterated Farlie-Gumbel-Morgenstern (IFGM) family. In addition, we find the Kullback-Leibler distance (K-L) between R[n] and Rn. Moreover, we study the Fisher information matrix (FIM) for record values and their concomitants about the shape-parameter vector of the IFGM family. Also, we study the relative efficiency matrix of that vector-estimator of the shape-parameter vector whose covariance matrix is equal to Cramer-Rao lower bound, based on record ´ values and their concomitants. In addition, the Fisher information number (FIN) of R[n] is derived. Finally, we evaluate the FI about the mean of exponential distribution in the concomitants of record values.
Analytical Modeling of the Functioning of the Pulsatory Liposome
Authors:   Astronomical Institute of the Romanian Academy, Cutitul de Argint street, nr. 5, Bucharest, Romania, CONSTANTIN DIANA R. , POPESCU DUMITRU ,   Institute of Mathematical Statistics and Applied Mathematics, ”Gheorghe Mihoc-Caius Iacob”, Department of Mathematical Modelling in Life Sciences, Calea 13 Septembrie street, nr. 13, Bucharest 5, Romania
Published: May 2024

In this paper the analytical solutions of the differential equations are presented. These equations describe the pulsatory liposome dynamics. We consider a unilamellar liposome filled with an aqueous solution of osmotic solute inserted in a hypotonic aqueous medium. Due to the osmosis process the liposome has a cyclic evolution. The lipid vesicle swells to a critical size, when a transbilayer pore suddenly appears. Part of the internal solution leaks through this pore. The liposome relaxes and returns to the initial size. The swelling starts again and the liposome goes through a periodical process. The swelling of the liposome is described by a differential equation. All the processes which contribute to the liposome relaxing and its coming back to the initial size are described by three differential equations. Based on some analytical
methods, we solve these equations and their explicit solutions are validated by comparing with previous study numerical results.
{highcharter} and the accessibility module: Part 5
Authors: Averick Mara
Published: May 2024

This final installment in our series on using the Highcharts accessibility module with {highcharter} is basically “extra credit.” (Read: I took the time to figure this out, so I’m sharing it. But, it’s probably not the most helpful post if you’re just trying to get the accessibility module working with {highcharter}.) We covered enabling the accessibility module, and getting basic keyboard navigation in part one.
Accessible {highcharter}: Part 4
Authors: Averick Mara
Published: May 2024

Back in the first post in this series I mentioned that the impetus for this whole endeavor was Silvia Canelón’s excellent collection of R-specific resources for making data visualizations more accessible (Canelón 2021). I wanted to fill the gap between the possibilities afforded by Highcharts’ accessibility module, and documented examples of module use with the {highcharter} package (Kunst 2021). Don’t worry, I have pull requests in the works
Free will: Philosophical views on the nature of human choice and limitations
Authors: Adli Maryam , Abykeeva-Sultanalieva Taalaigul
Published: May 2024

The need to explore free will arises from continuous reflection and discussion about the nature of human existence and the ability of humans to make free decisions. This need is compounded by ambiguity in views and approaches to this concept and its meaning for various aspects of life. The examination of free will becomes relevant due to the need to understand the causes of actions, moral responsibility, and the possibilities of human influence on the world. This study was devoted to the disclosure of key aspects of free will through the analysis of historical and modern theories. In the course of the study, a literary analysis was involved, which included work with papers on related subjects. The conceptual analysis allowed defining and understanding the main concepts and terms of the subject under study. Comparative analysis was applied to the papers of other researchers who worked on the same or similar subjects to identify similarities and differences and determine prospects for future research in this area. The study shows that there are two main directions in this discussion: determinists believe that all events, including human actions, are predetermined, and compatibilists state that free will is compatible with determinism. The study provides a detailed analysis of deterministic and compatibilist concepts of free will. Arguments for and against free will, which indicate the influence of external factors on human choice, are considered. Through the analysis of historical and modern theories, the examination of various concepts and argumentation, this study identifies the main approaches to the interpretation of the concept of free will in the context of philosophical thought. The main results indicate the complexity and versatility of the concept of free will and the importance of considering various factors that influence human choice
Studi Independent Prediksi Gempa Berbasis Website di Orbit Future Academy
Authors: Fadia Nabila , Itriyah
Published: May 2024

The Certified Independent Study Program, which is part of the Independent Campus initiative and supported by the Ministry of Education and Culture, Research and Technology, involves many large companies in academic collaboration. One of them is Orbit Future Academy, which provides special programs in the fields of Artificial Intelligence and Data Science. This program is specifically designed to develop web-based applications for earthquake prediction. The methodology used combines advanced Artificial Intelligence techniques in the field of Data Science, with the application of the K-Means Clustering and K-Nearest Neighbors (KNN) algorithms in earthquake prediction systems. The main objective of this program is to improve knowledge and skills in the application of Artificial Intelligence and Data Science for earthquake prediction, especially around real estate investment, thereby contributing to more informed decision-making in this sector.
Studi Independent Prediksi Harga Komoditi Petani Bawang Merah Menggunakan Amazon Forecast di PT. Techno International Mandira
Authors: Arisandy Desy , Apriani Tri
Published: May 2024

The Certified Independent Study, under the Kampus Merdeka initiative and supported by the Ministry of Education, Culture, Research, and Technology (Kemendikbud Ristekdikti), fosters collaborative partnerships with key industry players. A prime example is PT. Techno International Mandira's contribution, which involves employing Amazon Forecast within Amazon Web Services for the predictive analysis of shallot farmers' commodity prices. This study centers on developing web-based predictive models to accurately forecast shallot market values. Utilizing Amazon Forecast's fully managed services, which integrate advanced machine learning algorithms, this project aims to provide vital insights into commodity pricing trends, thereby supporting shallot farmers in strategic decision-making. The methodology encompasses the application of Amazon Forecast for efficient and data-driven price prediction, demonstrating the practical utility of machine learning in agricultural economics.
Pendampingan Konseling Gratis Melalui Aplikasi SIAPPAK : Untuk Meningkatkan Kesejahteraan Mental Masyarakat
Authors: Fadhiilah Rofi'atul , Wikartika Ira
Published: May 2024

Free counseling assistance through the SIAPPAK application is the latest innovation from the Surabaya government to improve the mental well-being of the community in the Bubutan sub-district. This research aims to explore the effectiveness of free counseling assistance through the SIAPPAK application in improving people's mental well-being. In the context of people's mental well-being, the SIAPPAK application can be an innovative solution for dealing with various psychological problems. This research makes an important contribution to the development of affordable mental health services, especially in settings that may have limited access to traditional services. The practical implications of these findings can provide a basis for the expansion and development of similar applications to maintain and improve the mental well-being of society. This research aims to 1. Improve the mental well-being of the community in Bubutan sub-district 2. provide access to affordable mental health services 3. Increase mental health awareness.
Análise do insucesso escolar no ensino secundário geral
Authors: Silvestre Januário Biché Daniela
Published: May 2024

Este artigo resulta de uma reflexão em torno do insucesso escolar e visa analisar as principais causas e consequências do insucesso escolar no ensino secundário geral na África Subsariana e em Moçambique. A pesquisa se configurou como um estudo teórico, a metodologia para a abordagem do trabalho consistiu na revisão bibliográfica de natureza qualitativa. Os resultados do estudo mostram-nos que o fenómeno é bastante complexo: No período analisado (2012, 2014, 2016 e 2018) a pesquisa constatou que houve maior desistência na 10ª classe do que na 12ª classe e, em 2018, desistiram menos alunos em ambas as classes relativamente a todo o período analisado. As causas de insucesso escolar são: abandono escolar de alunos antes da conclusão do ciclo, reprovações por diferença de idade cronológica e o nível escolar, falta de materiais pedagógicos, métodos e estratégias de ensino e aprendizagem usados pelos professores, problemas de aprendizagem, a falta de motivação, a baixa auto estima, os factores sócio económico, culturais,  étnicos,  influência do meio ambiente onde vive o aluno, condição financeira, a etnia e o baixo nível de educação dos pais tem um peso significativo no insucesso escolar. O insucesso escolar penaliza o jovem e a sociedade, porque a sua contribuição para diversos projectos do Estado, como a educação, os mesmos ficam inviabilizados.
Assessment of pain control in advanced cancer patients admitted to a palliative care unit
Authors: Amitrano Bilobran Marcela , Fernandes Duarte Costa Maria Fernanda , Regadas Muniz Andrezza , Almeida Chelles Patrícia , Tavares da Silva Neto Edson , Costa de Oliveira Livia , Garruth dos Santos Machado Sampaio Simone
Published: May 2024

Introduction: Pain in people with cancer is prevalent and should have an individualized therapeutic plan.
Objectives: To evaluate pain control in advanced cancer patients in a hospital palliative care unit.
Methods: This is a cohort study, with prospective design, and quantitative approach, including advanced cancer patients admitted to a palliative care unit between June 2021 and February 2022 reporting pain. Data was collected from medical records and the Brief Pain Inventory (BPI) was used to assess pain on the first (D1), third (D3) and seventh (D7) day of hospitalization.
Results: One hundred and four patients participated in the study. The most prevalent tumors were of the gastrointestinal tract (n=23; 22%), cervix (n=21; 20%) and breast (n=17; 16%). Abdomen was the most reported site of pain (n=34; 33%), with 50% classified as nociceptive pain, 39% neuropathic pain, and 11% mixed. On D1, 43% reported severe pain, 31% moderate, and 12% mild pain. There was an evolutionary drop in the percentage of severe pain (BPI3 70% to 37.1%; BPI4 12.6% to 5.4%; BPI5 42.5% to 13.5%; and BPI9 67.8% to 21.6%) according to the answers to all BPI questions during the period. On D1, D3 and D7, the average equipotent doses of oral morphine were 116 mg, 133 mg and 154 mg and the frequency of use of adjuvant use was 60%, 75%, and 69%, respectively.
Conclusions: Pain was properly controlled and was related to the increased use of adjuvants, both for general and neuropathic pain. It was possible to observe that the use of adjuvants was related to better pain control.
Advancements and Challenges Forensic Odontology and Anthropology: Applications for Identification in Saudi Arabia
Authors: Al Yousef Ali , Althubaiti Haytham
Published: May 2024

The evolution of forensic science has witnessed significant progress in dental identification techniques, originating from prehistoric eras but gaining prominence in the late 19th century. During the 1960s, forensic odontology experienced renewed interest, extending its relevance beyond dentistry to law enforcement agencies. This resurgence coincided with the emergence of forensic anthropology, vital in employing skeletal analysis to reconstruct the biological profiles of unidentified individuals. Collaborative efforts of forensic dentistry and anthropology have notably enhanced the accuracy and scope of forensic investigations, especially in cases involving incomplete or decomposed remains. In the Kingdom of Saudi Arabia, despite cultural challenges, the significance of multidisciplinary collaboration to assist the law enforcement agencies cannot be overstated. As forensic science advances, the integration of dental and skeletal analyses remains crucial for effective case resolution. Forensic odontology and anthropology jointly contribute to identifying individuals in mass disasters and criminal cases through dental record and skeletal remains analysis. Both disciplines boast rich historical backgrounds, dating back to ancient civilizations. Limited practices and training in Saudi Arabia pose obstacles for forensic investigations, although there is evident public acceptance regarding the importance of maintaining dental records and recognizing skeletal analysis significance. Therefore, establishing a national registry for dental and skeletal data, coupled with comprehensive training programs, is recommended for dentistry and anthropology students at all academic levels.
The effect of orthodontic Force Application and Tooth Movement on Dental Pulp
Authors: Alswegi Sokaena , Ghabasa Alkhansa , Habibi Hesham
Published: May 2024

This systematic review aimed to conclusively investigate the effect of continuous intrusive force application on human pulpal blood flow (PBF). It is a well-established fact that applying a severe orthodontic force for an extended period can cause irreversible pulpitis and necrosis in the pulp by accelerating the inflammation process. In contrast, utilizing moderate and intermittent forces allows for ample tooth movement, limits pulp damage, and facilitates pulp healing. Materials and methods: A comprehensive search of published studies was conducted in several electronic databases such as MEDLINE, PubMed, EMBASE, Scopus, Web of Science, CINAHL, and the Cochrane Database of Systematic Reviews, as well as Google Scholar. The search was conducted without limitations to find published studies. The results showed that orthodontic forces can lead to a decrease in pulpal blood flow, which causes a reduction in tooth sensitivity. This reduction is indicated by an increase in response thresholds and more negative responses to tooth sensitivity tests. Conclusion: applying a severe orthodontic force over a prolonged period of time can lead to irreversible pulpitis and necrosis in the pulp due to an increase in the inflammation process. However, using moderate and intermittent forces can facilitate sufficient tooth movement while minimizing damage to the pulp. This highlights the importance of the endodontic-orthodontic interface and the need to consider dental pulp health during orthodontic treatment to avoid dental trauma.
OLIY TA’LIM MUASSASALARI MOLIYAVIY RESURSLARI SHAKLLANISH TIZIMINI BOSHQARISH AMALIYOTINING TAHLILI
Authors: Karlibaeva Gulshat
Published: May 2024

Hozirgi sharoitda aksariyat O‘zbekiston oliy ta’lim muassasalarida akademik faoliyatning rivojlanishi ular daromadlarining shakllanishida to‘lov-shartnoma asosidagi daromadlarning jami daromadlardagi ulushining yuqori ko‘rsatkichini ta’minlamoqda. Toshkent davlat iqtisodiyot universiteti faoliyatini moliyalashtirishda to‘lov-shartnoma faoliyatidan tushumlar yetakchi rol o‘ynaydi. Bu, o‘z navbatida, faoliyat aspektrini kengaytirish va diversifikatsiya qilish bilan bog‘liq tizimli islohotlarni amalga oshirishni taqozo etadi. Tahlillar, oliy ta’lim muassasalarida moliyaviy rejalashtirish tizimi universitetlar joriy rivojlanishi bilan bog‘liq taktik vazifalarni real holatda to‘liq hisobga olmaydi. Ushbu holat oliy ta’lim muassasalarida moliyaviy rejalashtirish tizimini zamonaviy shart-sharoitlarga asoslangan holda takomillashtirishni va ilg‘or usullarni joriy qilishni taqozo qiladi.
INCREASING ROLE OF THE NATURAL FACTOR IN SUSTAINABLE DEVELOPMENT
Authors: Rakhmatova Zilola
Published: May 2024

This article examines the escalating importance of natural factors in sustainable development, spotlighted by the adverse consequences of historical exploitative environmental practices. These practices have generated a colossal ecological and social debt, manifesting as severe environmental crises that undermine global stability. A paradigm shift towards sustainable development is imperative for fostering security, equality, and harmony between human societies and the biosphere. Sustainable development, though conceptually elusive, fundamentally aims to redefine the interaction between human civilization and the natural environment for enduring coexistence.
SANOAT TARMOQLARIDA ISHLAB CHIQARISH SAMARADORLIGINI OSHIRISHNING NAZARIY ASOSLARI
Authors: Raximov Anvar , Avazova Nafisa
Published: May 2024

Maqolada sanoat tarmoqlarida ishlab chiqarish samaradorligi hozirgi kundagi dolzarb mavzulardan biri ekanligi, hamda uni oshirishga qaratilgan bir qancha xorijiy va mahalliy olimlarning fikr-mulohazalari bayon etilgan. Sanoat korxonalarining ishlab chiqarish samaradorligini oshirish uchun amalga oshirish lozim bo‘lgan ishlar nazariy jihatdan yoritilib berilgan va bu bo‘yicha xulosa va takliflar berilgan.
O’ZBEKISTON SOLIQ TIZIMIDA BILVОSITА SОLIQLАR BАZАSINI АNIQLАSHNING USLUBIYАTI VА ОʻZIGА XОS XUSUSIYАTLАRI TАHLILI
Authors: Xalikchayeva Sadokat
Published: May 2024

Ushbu maqolada O’zekiston Respublikasi soliq tizimida mavjud bilvosita soliqlar hisoblangan aksiz va qo’shilgan qiymat solig’ining bazasini aniqlash tartibi, uning amal qilish mexanizmi, xususiyatlari, shuningdek, olib borilayotgan soliq siyosati jarayonlarining bu soliqlar bazasiga ta’sir xususiyatlari masalalari ko’rib chiqilgan. Xususan, bilvosita soliqlarning bazasiga ta’sir etuvchi omillarga tadqiqot jarayonida alohida ta’xtalib o’tilgan.
СУҒУРТА БОЗОРИ: ЗАМОНАВИЙ ҲОЛАТ ВА РИВОЖЛАНИШ ТЕНДЕНЦИЯЛАРИ
Authors: Абдурахмонов Ильёс
Published: May 2024

Мақолада суғурта бозорининг иқтисодиётдаги тутган ўрни, замонавий ҳолати ва ривожланиш тенденциялари ёритилган, ҳамда суғурта бозорининг лозим даражада ривожланишига салбий таъсир кўрсатаётган омиллар, муаммолар ва уларнинг ечимлари бўйича фикр юритилган.
ҲАҚҚОНИЙ ҚИЙМАТНИ АНИҚЛАШ ИМКОНИ БЎЛМАГАН БИОЛОГИК АКТИВЛАР ҲИСОБИНИ ТАКОМИЛЛАШТИРИШ
Authors: Болтаев Аброр
Published: May 2024

Ушбу мақолада ҳаққоний қийматни аниқлаш имкони бўлмаган биологик активлар ҳисобини такомиллаштириш масалалари ёритилган. Хусусан, ҳаққоний қийматни аниқлаш имкони бўлмаган биологик активларни дастлабки тан олиш, бухгалтерия ҳисоби ва молиявий ҳисоботда акс эттириш ҳамда улар бўйича маълумотларни ёритиб бериш тартиби таклиф этилган ва хулосалар шакллантирилган.
КΟРХΟНАЛАРДА ИННΟВАЦИΟН ЖАРАЁНЛАРНИ САМАРАЛИ ТАШКИЛ ЭТИШ ЙЎНАЛИШЛАРИ
Authors: Гафурова Умида
Published: May 2024

Мақолада мамлакатимиз иннοвациοн фаοлияти ва кοрхοналарда иннοвациοн жараёнларни самарали ташкил этиш йўналишлари ёритилган. Шу билан бирга Ўзбекистон Республикасида иннοвациοн ривοжланишни жадаллаштириш, иқтисοдиётнинг барча тармοқларида иннοвациялар ва технοлοгияларни кенг татбиқ қилиш, инсοн капитали, илм-фан ва иннοвация сοҳаларини ривοжлантириш борасида таклиф ва тавсифлар келтирилгандир
ЎЗБЕКИСТОН ИҚТИСОДИЁТИ ТАРМОҚЛАРИДА ТАДБИРКОРЛИК СУБЪЕКТЛАРИНИ МАҚСАДЛИ РАҒБАТЛАНТИРИШНИ ТАКОМИЛЛАШТИРИШ
Authors: Исаев Аслиддин
Published: May 2024

Мақолада мамлакатимиз тармоқларида тадбиркорлик субъектларини мақсадли рағбатлантиришни такомиллаштириш масалалари ёритилган бўлиб, мавзу доирасида иқтисодчи олимларнинг тадқиқотлари ўрганилган. Ўзбекистонда рақамли инновациялар ва тадбиркорликни ривожлантиришга қаратилган солиқ имтиёзлари бўйича кўриб чиқилган. Тадқиқот иши якунида муаллиф томонидан хулоса ва таклифлар шакллантирилган.
ФОЙДАЛИ ҚАЗИЛМАЛАРНИ НАЗОРТИ МАРКШЕЙДЕРЛИК ИШЛАРИНИ ТАШКИЛ ЭТГАН ҲОЛДА СОЛИҚ БАЗАСИНИ КЕНГАЙТИРИШ МАСАЛАЛАРИ
Authors: Камилов Аброр
Published: May 2024

Мазкур мақолада республикамизда сўнгги йилларда мамлакатда маркшейдерлик ишларини ташкил этган ҳолда солиқ базасини кенгайтириш масалалари, уларни аниқлаш механизмларини такомиллаштиришдан самарали фойдаланиш масалалари ҳамда солиқ идоралари томонидан солиқ маъмурчилиги инструментларидан фойдаланиш орқали ҳуқуқбузарликларни бартараф этиш, солиқ тўлашдан бўйин товлаш схемаларини ўз вақтида ошкор қилиш чора-тадбирларини амалга ошириш, солиқ маъмурчилигининг янада оптималлаштириш, қонун ҳужжатларидаги қарама-қаршиликларни бартараф этиш бўйича илмий-амалий хулоса ва таклифлар ишлаб чиқилган
САВДО КОРХОНАЛАРИДА ЧЕГИРМАЛАР ҲИСОБИНИ ТАКОМИЛЛАШТИРИШ
Authors: Пўлатов Худойберди
Published: May 2024

Мазкур мақолада савдо чегирмаларни ҳозирги замон талаблари асосида бухгалтерия ҳисобни методологиясини ишлаб чиқиш ва ундаги муаммоларни бухгалтерия хисобида ва ҳисоботларида туғри юртилиш олиб бориш ёритилган
МИРОВЫЕ ТЕНДЕНЦИИ И СРАВНИТЕЛЬНАЯ ОЦЕНКА ПОЛИТИКИ УРБАНИЗАЦИИ В ЗАРУБЕЖНЫХ СТРАНАХ
Authors: Салимова Юлдуз
Published: May 2024

В статье доказано наличие следующих известных мировых тенденций развития процесса урбанизации: неуклонный рост численности городского населения практически во всех странах; этапность процесса урбанизации (прохождение доиндустриального, индустриального и постиндустриального этапов); рост числа мегагородов в мире; различия в протекании процессов урбанизации в развитых и развивающихся странах; зависимость уровня урбанизации от уровня экономического развития страны. На основе сравнительного анализа зарубежной практики урбанизации систематизированы существующие мировые модели урбанизации, применяемые инструменты (Беларусь, Гана, Казахстан, Республика Корея, Китай, Польша, Россия, Танзания, Турция, Япония). Исходя из достигаемых эффектов, обоснована необходимость рассмотрения урбанистической политики в аспекте комплексного регионального развития развивающихся странах, включая Республику Узбекистан
АҲОЛИ ДАРОМАДЛАРИ ТАБАҚАЛАШУВИНИ КАМАЙТИРИШ БОРАСИДАГИ ИСЛОҲАТЛАРНИ ТАКОМИЛЛАШТИРИШ ЙЎНАЛИШЛАРИ
Authors: Султонов Сирожиддин
Published: May 2024

Аҳолини ижтимоий табақалашуви ва уларни турмуш даражасини яхшилаш, тенгсизликни камайтиришга қаратилган. Бундан ташқари аҳоли даромадларининг тақсимланиши ва қайта тақсимланиши масалаларининг ҳал қилиниши нафақат муҳтожларга фаровон турмуш даражаси таъминланади. Норосмий секторда маълум маънода бандликнинг таъминланиши ходимлар ижтимоий ҳуқуқларини ҳимоя қилишга қаратилган. Мамлакатимизда аҳоли даромадларни табақалашув даражасининг камайтириш мақсадидада жисмоний шахслар даромадларига нисбатан прогрессив солиқ ставкаларни ўрнатилиши. Тадбиркорлик фаолияти орқали янги иш ўринллар ва дароматларни оширишга қаратилган.
ILMIY DARAJALI KADRLAR TAYYORLASH JARAYONINI STATISTIK TAHLIL QILISH VA PROGNOZLASH
Authors: Fazliddinov Shohruh
Published: May 2024

Maqolada ilmiy darajaga ega bo‘lgan kadrlar tayyorlashning muhim muammosi va bu jarayonni bashorat qilish uchun statistik tahlildan foydalangan holda sohadagi imkoniyatlar ko‘rib chiqilgan. Ilmiy darajali kadrlar tayyorlash jarayonlarini o‘rganish va bashorat qilish uchun statistik tahlildan foydalanish ushbu jarayonni boshqarish samaradorligini sezilarli darajada oshiradi, o‘quv xarajatlarini optimallashtiradi va ilmiy darajali kadrlarga bo‘lgan ehtiyojni aniqroq rejalashtirishni ta’minlaydi. Ushbu tadqiqotdagi ma’lumotlardan foydalanish orqali ilmiy darajaga ega bo‘lgan kadrlar tayyorlash tizimini rivojlantirish va ularning mehnat bozorida raqobatbardoshligini oshirishga erishish mumkin.
СОЛИҚЛАРНИ ТАҲЛИЛ ҚИЛИШ МЕТОДИКАСИНИНГ НАЗАРИЙ АСОСЛАРИ
Authors: Турсунова Гулноза
Published: May 2024

Ушбу тадқиқот ишида солиқ таҳлилида қўлланиладиган мавжуд методлар, жумладан, иқтисодий моделлар, эмпирик усуллар, қиёсий тадқиқотлар ва солиқ қонунчилигига риоя қилиш бўйича тадқиқотлар ҳақида умумий маълумот берилган. Ушбу методологиянинг кучли томонлари, чекловлари ва қўлланилишини ўрганиш орқали ушбу тадқиқот солиқлар ва иқтисодий натижалар ўртасидаги мураккаб муносабатларни чуқурроқ тушунишга ёрдам беради
КОРХОНА БОШҚАРУВИДА ХАРАЖАТЛАР ХИСОБИНИНГ АҲАМИЯТИ ҲАМДА ХУСУСИЯТЛАРИ
Authors: Урманбекова Ирода
Published: May 2024

Бугунги кунда иқтисодиётимизда харажатлар ва таннархни пасайтириш орқали маҳсулот рақобатбардошлигини ошириш муҳим вазифа сифатида қаралмоқда. Шу боисдан, корхона бошқарувида харажатлар ҳисобининг назарий, методологик ва амалий жиҳатлари махсус, мустақил тадқиқот объекти сифатида ўрганиш долзарб ва илмий-амалий аҳамият касб этади. Мазкур мақолада корхона бошқарувида ишлаб чиқариш харажатларининг мазмуни, аҳамияти ҳамда унинг хусусиятлари ва вазифалари очиб берилган
КОРХОНАЛАР ФОЙДАСИНИНГ ҲУҚУҚИЙ ЖИҲАТДАН КАМАЙИШИГА ОЛИБ КЕЛУВЧИ ОБЪЕКТИВ ОМИЛЛАРНИ ҲИСОБГА ОЛИШНИНГ ЎЗИГА ХОС ХУСУСИЯТЛАРИ
Authors: Худайкулов Амир
Published: May 2024

Ушбу мақолада Ўзбекистонда корхоналар фойдасининг ҳуқуқий жиҳатдан камайишига олиб келувчи объектив омилларни ҳисобга олишнинг ўзига хос хусусиятлари – корхоналарда бўнак ҳисоботини расмийлаштириш ва унда суткалик овқатланиш харажаларини меъёрдан ортиқ қисмини пировардида харажатларнинг ортишига ва фойданинг камайишига олиб келиши мисолида таҳлилий равишда, бухгалтерия ўтказмаларида ёритиб беришга ҳаракат қилинган