bluuebunny/crossref_metadata_2025 huggingface dataset:
Dampak dan Upaya Penanggulangan Terjadinya Abrasi Menggunakan Citra Satelit Studi Kasus Di Wilayah Pesisir Tanjung Benoa Bali
Authors: Apriyanti Dessy
Published: May 2023

Kawasan pantai merupakan satu kawasan yang sangat dinamik begitu pula dengan garis pantainya. Garis pantai adalah batas pertemuan antara bagian laut dan daratan pada saat terjadi air laut pasang tertinggi. Perubahan terhadap garis pantai adalah suatu proses tanpa henti (terus menerus) melalui berbagai proses baik pengikisan (abrasi) maupun penambahan (akreasi) pantai yang diakibatkan oleh pergerakan sedimen, arus susur pantai ( longshore current), tindakan ombak dan penggunaan tanah (Vreugdenhil , 1999). Tanjung adalah bagian daratan yang menjorok ke laut. Cakupan wilajah kajian kami yakni mengambil wilayah di Tanjung Benoa, Bali. Banyak media massa di Bali saat ini yang memberitakan kondisi Tanjung Benoa sangat memprihatinkan dan terus mengalami abrasi. Salah satu pendapat di media massa menyebutkan, “Abrasi semakin hari semakin mengancam Tanjung Benoa. Kalau tidak segera direklamasi bisa berbahaya,” (Wayan Ranten, Pos Bali). Namun dari berbagai pem beritaan di media massa, belum ada yang menyebutkan seberapa luas sebenarnya abrasi yang sudah terjadi di daerah Tanjung Benoa tersebut hingga tahun 2017. Efek dari adanya abrasi ini mengakibatkan tergerusnya lahan disekitar Tanjung Benoa, hal ini mengakibatkan rusaknya ekosistem di pesisir Tanjung Benoa. Untuk mengetahuidan mempelajari peristiwa abrasi serta mengetahui berapa luasan daerah yang mengalami abrasi yang terjadi di daerah sekitar Tanjung Benoa, dilakukan analysis multi temporal dengan pemantaua n menggunakan bantuan teknologi penginraan jauh dengan waktu pemantauan yang berbeda atau multi temporal. Teknologi pengindraan jauh yang digunakan yakni satelit. Citra satelit secara multitemporal dapat dianalysis menggunakan Sistem Informasi Geografis (SIG) kemudian dilihat luas daerah yang mengalami abrasi di Tanjung Benoa. Dengan diketahui besarnya luas daerah akibat abrasi tersebut, maka dapat dijadikan rujukan bagi pemerintah setempat untuk mengambil tindakan pencegahan abrasi pantai di Tanjung Beno a, agar tidak menjadi semakin parah. Kata kunci: Abrasi, Tanjung Benoa, Citra satelit, SIG
Pemodelan 3 Dimensi Candi Kedulan Menggunakan Terrestrial Laser Scanner
Authors: Pramudya Aditya Firman
Published: May 2023

Perkembangan teknologi dalam survey pemetaan pada masa kini berkembang sangat cepat. Dimulai dengan alat-alat yang bersifat manual dan konvensional,sekarang banyak teknologi survey pemetaan yang bersifat otomatis dan canggih. Salah satunya yang berkembang saat ini adalah teknologi untuk survey suatu obyek tiga dimensi, yakni terrestrial laser scanner. Terrestrial Laser Scanner (TLS) adalah suatu teknologi metode pengukuran ground based yang mampu memberikan visual hasil dokumentasi dalam model 3 dimensi (3D) dengan proses akuisisi data yang efektif dan perekamannya secara realtime, aktual, dan dimensional (Leonardo, 2008). Pada penelitian menggunakan data yang dilaksanakan di Candi Kedulan Dusun Kedulan, Desa Tirtomartani, Kecamatan Kalasan, Kabupaten Sleman, Daerah Istimewa Yogyakarta. Penelitian tersebut dilakukan untuk mengetahui seberapa dalam candi kedulan terpendam oleh endapan sedimen Dalam rangka melaksanakan penelitian ini, kegiatan dilakukan adalah membuat atau merepretasikan Candi Kedulan dalam bentuk tiga dimensi, dengan menggunakan TLS diharapkan dapat membentuk kedetailan yang cukup tinggi.
Pembuatan Aplikasi Peta Interaktif 3 Dimensi (Studi Kasus: Pondok Pesantren Al Munawwir Krapyak Yogyakarta)
Authors: Fahmi Afrizal Amri
Published: May 2023

Pondok Pesantren Al Munawwir Krapyak Yogyakarta adalah lembaga pendidikan dan sosial keagaamaan yang berdiri sejak 15 November 1911 dengan luas area kurang lebih 5,876 hektar. Area Pondok Pesantren Al Munawwir tidak memiliki batas area pondok yang jelas sehingga kerap membuat pengunjung yang datang ke kompleks Pondok Pesantren Al Munawwir kesulitan dalam menemukan lokasi kompleks pondok pesantren. Oleh karena itu, perlu adanya informasi pondok pesantren secara visual seperti peta 3D yang interaktif yang dapat menunjukkan bangunan kompleks Pondok Pesantren Al Munawwir, agar dapat membantu mengatasi permasalahan tersebut. Penelitian ini dilakukan untuk membuat peta interaktif 3D untuk membantu mengatasi permasalahan tersebut.Pembuatan peta interaktif 3D ini menggunakan perangkat lunak yaitu unreal engine. Unreal engine merupakan sebuah game engine yang sedang berkembang dan banyak digunakan dalam pembuatan peta 3D maupun game (Epic Games, 2011). Perangkat lunak ini memiliki kemampuan untuk membuat lingkungan virtual yang sesuai dengan dunia nyata. Penggunaan unreal engine dipilih karena merupakan perangkat lunak yang  bersifat open source sehingga bebas dikembangkan dengan mudah oleh siapapun.Hasil dari pembuatan aplikasi adalah aplikasi peta interaktif 3D Pondok Pesantren Al Munawwir. Pengujian aplikasi peta interaktif 3D dilakukan dengan pengujian fungsional dan non fungsional. Pengujian fungsional untuk mengetahui apakah aplikasi peta interaktif 3D dapat berjalan dengan baik sedangkan pengujian non fungsional untuk mengetahui spesifikasi untuk menjalankan aplikasi peta interaktif 3D. Hasil pengujian ini menunjukkan aplikasi peta interaktif 3D dapat berjalan dengan baik. Spesifikasi yang direkomendasikan untuk menajalankan aplikasi peta interaktif 3D ini yaitu Intel Core i5 8300H, Memory 8GB DDR4, NVIDIA GeForce GTX 1050 4GB.
Pemetaan Kerawanan Fisik Longsor Kecamatan Petungkriyono Dengan Metode Pembobotan Peraturan Menteri Pekerjaan Umum No. 22/PRT/M/2007
Authors: Arrisaldi, S.T., M.Eng. Thema
Published: May 2023

Kecamatan Petungkriyono merupakan salah satu kecamatan di Kabupaten Pekalongan yang memiliki kondisi morfologi berupa pegunungan dan lembah. Hal ini membuat Petungkriyono sering terjadi bencana longsor yang merugikan masyarakat, oleh karena itu pemetaan kerawanan longsor perlu dilakukan pada daerah ini. Metode Pembobotan menggunakan Peraturan Menteri Pekerjaan Umum No. 22/PRT/M/2007 mengenai penataan kawasan rawan bencana longsor. Dalam pemetaan kerawanan fisik ini terdiri dari 7 parameter, yaitu : kelerengan (30%), kondisi geologi (20%), kondisi tataguna lahan(10%), densitas aliran air (7%), tebal tanah(15%), kondisi curah hujan (15%), dan kondisi kegempaan (3%). Metode pemetaan yang dilakukan yaitu dengan pemetaan langsung kemudian dilakukan pengolahan data untuk setiap parameter dan analisis overlay menggunakan sistem informasi geografis (SIG). Hasil pengamatan yang dilakukan kondisi kelerngan daerah ini memiliki kelerengan rendah hingga kelerengan tinggi. Kondisi geologi daerah ini dibagi menjadi 4 satuan batuan, yaitu : endapan bongkah andsesit basaltic, satuan vulkanik III (lava dan breksi vulkanik), satuan vulkanik II (lava dan breksi vulkanik), dan satuan vulkanik I (lava dan breksi vulkanik). Kondisi tataguna lahan area ini didominasi oleh hutan dan perkebunan. Kondisi ketebalan tanah menunjukan daerah ini didominasi dengan tabal tanah yang > 1 meter dengan kondisi tidak gembur. Densitas aliran air didominasi oleh densitas aliran air sedang hingga tinggi. Kondisi curah hujan daerah Petungkriyono memiliki curah hujan yang tinnggi (>2000mm/tahun), sedangkan kondisi kegempaan pada daerah ini terletak pada area dengan kegempaan rendah. Setelah mendapatkan kondisi parameter dilakukan pembobotan dengan Peraturan Menteri Pekerjaan Umum No. 22/PRT/M/2007 dengan menggunakan SIG hasilnya berupa peta kerawanan fisik longsor. Kondisi kerawanan fisik longsor daerah Petungkriyono terdapat 3 kerawanan fisik yaitu : kerawanan fisik rendah memiliki luasan 0,0228 km2, kerawanan fisik sedang memiliki luasan 73,88 km2, dan kerawanan fisik tinggi memiliki luasan 10,27 km2
Penggunaan Citra Landsat untuk Pendeteksian Anomali Suhu Permukaan Sebagai Indikasi Keberadaan Manifestasi Panas Bumi. Studi Kasus: Sipoholon, Indonesia
Authors: Mardiati, S.T., M.Eng. Dani
Published: May 2023

Sipoholon merupakan sebuah kecamatan yang terletak di Kabupaten Tapanuli Utara, Sumatera Utara yang dilewati oleh Sistem Sesar Sumatera. Berdasarkan peta Geologi Lembar Sidikalang, ditemukan adanya manifestasi panas bumi berupa mata air panas (hot spring) di daerah tersebut. Keberadaan manifestasi ini menunjukkan adanya sistem panas bumi yang bekerja di bawahnya. Keberadaan manifestasi panas bumi di suatu daerah akan berpengaruh terhadap suhu permukaan tanah di daerah tersebut. Pendeteksian anomali suhu permukaan tanah dapat dilakukan dengan berbagai cara. Salah satu metode yang mudah untuk dilakukan yaitu menggunakan Citra Penginderaan Jauh. Citra Landsat merupakan salah satu citra penginderaan jauh yang dapat digunakan untuk mendeteksi anomali suhu permukaan. Penelitian ini bertujuan untuk mendeteksi anomali suhu permukaan sebagai indikasi adanya manifestasi panas bumi di Sipoholon, Sumatera Utara menggunakan Citra Landsat. Band 10 dan band 11 yang merupakan thermal infrared (TIR) diolah untuk mendapatkan suhu kecerahan (brightness temperature). Band 4 dan 5 digunakan untuk menghitung kerapatan vegetasi (NDVI) dan emisivitas suhu permukaan. Gabungan dari band 10, band 11 dan NDVI digunakan untuk menghitung nilai suhu permukaan tanah (Land Surface Temperature). Data lapangan berupa suhu mata air panas dan suhu permukaan tanah  diambil untuk melakukan verifikasi terhadap analisis citra yang telah dilakukan. Hasil analisis citra menunjukkan bahwa suhu permukaan di lokasi penelitian berkisar antara 16,7°C sampai dengan 28,4°C. Anomali suhu tinggi berada di daerah yang dilewati oleh sesar sumatera. Hasil verifikasi di lapangan menunjukkan hasil yang selaras, terdapat mata air panas di daerah yang dilewati oleh sesar sumatera dengan suhu 35,7 °C – 64,4°C. Sedangkan suhu permukaan tanah berkisar antara 31,3°C – 48,7°C. Hal ini menunjukkan bahwa citra landsat berupa suhu permukaan tanah (LST) dapat digunakan untuk mendeteksi anomali suhu permukaan sebagai indikasi adanya sistem panas bumi di suatu daerah untuk memudahkan pengerucutan lokasi pada tahap eksplorasi.
Bayesian Binary reciprocal LASSO quantile regression (with practical application)
Authors: Al-mayali Mohammet T. Kahnger
Published: May 2023

Quantile regression is one of the methods that has taken a wide space in application in the previous two decades because of the attractive features of these methods to researchers, as it is not affected by outliers values, meaning that it is considered one of the robust methods, and it gives more details of the effect of explanatory variables on the dependent variable.In this paper, a Bayesian hierarchical model for variable selection and estimation in the context of binary quantile regression is proposed. Current approaches to variable selection in the context of binary classification are sensitive to outliers, heterogeneous values, and other anomalies. The proposed method in this study overcomes these problems in an attractive and direct way.
Weiner Topological Index for Neutrosophic Graph based on Strong Domination Set and Number
Authors: Zandi Amir_majeed , Nabeel Ezzulddin Arif2
Published: May 2023

Different topological indices will always be valuable in a variety of disciplines, including chemistry, economics, electronics, business studies, social sciences and medicine. According to the dominating set and number, the Wiener index for neutrosophic graphs (NG) will be studied in considerable detail in this research.

Additionally, the Average Wiener index for an NG has been defined, and several associated theorems have been introduced.
Delayed fatal intracranial hemorrhage in a pediatric patient following resection and adjuvant cranial radiotherapy for ependymoma: illustrative case
Authors: Farmer Matthew L. , Conley Adam M. , Dilustro Joseph F.
Published: May 2023

BACKGROUND

Cranial radiotherapy (CRT) is an important treatment modality for malignancies of the central nervous system. CRT has deleterious effects that are commonly classified into acute, early delayed, and late delayed. Late-delayed effects include weakening of the cerebral vasculature and the development of structurally abnormal vasculature, potentially leading to ischemic or hemorrhagic events within the brain parenchyma. Such events are not well reported in the pediatric population.

OBSERVATIONS

The authors present the case of a 14-year-old patient 8.2 years after CRT who experienced intracerebral hemorrhage. Autopsy demonstrated minimal pathological change without evidence of vascular malformation or aneurysm. These findings were unexpected given the degree of hemorrhage in this case. However, in the absence of other etiologies, it was believed that late-delayed radiation effect was the cause of this patient’s fatal hemorrhage.

LESSONS

Although not all cases of pediatric spontaneous intracerebral hemorrhage will have a determined etiology, the authors’ patient’s previous CRT may represent a poorly defined risk for late-delayed hemorrhage. This correlation has not been previously reported and should be considered in pediatric patients presenting with spontaneous hemorrhage in a delayed fashion after CRT. Neurosurgeons must not be dismissive of unexpected events in the remote postoperative period.
Trigeminal neuralgia secondary to vascular compression and neurocysticercosis: illustrative case
Authors: Vásquez Mao , Saavedra Luis J. , García Hector H. , Vela Evelyn , Medina Jorge E. , Lozano Miguel , Hoyos Carlos , Lines-Aguilar William W.
Published: May 2023

BACKGROUND

Trigeminal neuralgia (TN) is a frequent neurosurgical problem negatively influencing the quality of life of patients. The standard surgical treatment is microvascular decompression for primary cases and decompression of the mass effect, mainly tumors, for secondary cases. Neurocysticercosis (NCC) in the cerebellopontine angle is a rare etiology of TN. The authors report a case in which NCC cysts around the trigeminal nerve coexisted with a vascular loop, which compressed the exit of the trigeminal nerve from the pons.

OBSERVATIONS

A 78-year-old woman presented with a 3-year history of persistent severe pain in the left side of her face, refractory to medical treatment. On gadolinium-enhanced magnetic resonance imaging, cystic lesions were observed around the left trigeminal nerve and a vascular loop was also present and in contact with the nerve. A retrosigmoid approach for cyst excision plus microvascular decompression of the trigeminal nerve was successfully performed. There were no complications. The patient was discharged without facial pain.

LESSONS

Albeit rare, TN secondary to NCC cysts should be considered in the differential diagnosis in NCC-endemic regions. In this case, the cause of the neuralgia was probably both problems, because when both were treated, the patient improved.
Endovascular treatment of a ruptured pure arterial malformation and associated dysplastic middle cerebral artery dissecting aneurysm: illustrative case
Authors: Marlow Christine , Cuoco Joshua A. , Ravina Kristine , Sloboda Cole A. , Entwistle John J.
Published: May 2023

BACKGROUND

Pure arterial malformations are characterized as unique cerebrovascular lesions with a dilated, coil-like appearance and tortuous arteries without early venous drainage. Historically, these lesions have been described as incidental findings with a benign natural history. However, pure arterial malformations can rarely demonstrate radiographic progression and develop associated focal aneurysms with an unclear risk of rupture. Whether radiographic progression of these lesions or the presence of an associated aneurysm warrants treatment remains controversial.

OBSERVATIONS

A 58-year-old male presented with sudden-onset left hemiparesis. Computed tomography revealed a large, acute, right frontotemporoparietal intraparenchymal hemorrhage with underlying irregular curvilinear calcifications. Diagnostic cerebral angiography revealed a dysplastic right middle cerebral artery dissecting aneurysm along the M2 segment associated with a pure arterial malformation, which was treated with endovascular flow diversion in a delayed fashion.

LESSONS

Pure arterial malformations with associated focal aneurysms may not exhibit a benign natural history as once thought. Intervention should be considered for ruptured pure arterial malformations to mitigate the risk of rerupture. Asymptomatic patients with a pure arterial malformation with an associated aneurysm should at least be followed closely with interval radiographic imaging to evaluate for malformation progression or changes in aneurysmal morphology.
Etiology of spastic foot drop among 16 patients undergoing electrodiagnostic studies: patient series
Authors: Shields Lisa B. E. , Iyer Vasudeva G. , Zhang Yi Ping , Shields Christopher B.
Published: May 2023

BACKGROUND

Differentiating foot drop due to upper motor neuron (UMN) lesions from that due to lower motor neuron lesions is crucial to avoid unnecessary surgery or surgery at the wrong location. Electrodiagnostic (EDX) studies are useful in evaluating patients with spastic foot drop (SFD).

OBSERVATIONS

Among 16 patients with SFD, the cause was cervical myelopathy in 5 patients (31%), cerebrovascular accident in 3 (18%), hereditary spastic paraplegia in 2 (12%), multiple sclerosis in 2 (12%), chronic cerebral small vessel disease in 2 (12%), intracranial meningioma in 1 (6%), and diffuse brain injury in 1 (6%). Twelve patients (75%) had weakness of a single leg, whereas 2 others (12%) had bilateral weakness. Eleven patients (69%) had difficulty walking. The deep tendon reflexes of the legs were hyperactive in 15 patients (94%), with an extensor plantar response in 9 patients (56%). Twelve patients (75%) had normal motor and sensory conduction, 11 of whom had no denervation changes of the legs.

LESSONS

This study is intended to raise awareness among surgeons about the clinical features of SFD. EDX studies are valuable in ruling out peripheral causes of foot drop, which encourages diagnostic investigation into a UMN source for the foot drop.
Ondine’s curse: clinical presentation with diaphragmatic pacing and spontaneous respiratory recovery. Illustrative case
Authors: Schupper Alexander J. , Devarajan Alex , Lee Dong-Seok , Perez Enrique , Shrivastava Raj K.
Published: May 2023

BACKGROUND

The complexity of posterior fossa surgery can often lead to rare complications due to the anatomy involved. Vestibular schwannoma resection is a common pathology in the posterior fossa, often requiring surgical intervention. Given the proximity of this space to the brainstem, cranial nerve VII/VIII complex, and posterior inferior cerebellar artery (PICA), neurovascular complications are not infrequent. A rare vascular complication from this surgical approach is a lateral medullary infarction from injury to the lateral medullary segment of the proximal PICA, leading to central hypoventilation syndrome (CHS).

OBSERVATIONS

This report presents a unique case of a 51-year-old man who underwent a retrosigmoid craniectomy for resection of a vestibular schwannoma. Following surgery, the patient was unable to be weaned off the ventilator and was noted to become apneic while he slept, a clinical picture consistent with Ondine’s curse.

LESSONS

This report discusses the anatomical considerations of this surgical corridor leading to this complication and the management of a patient with acquired Ondine’s curse and reviews the scarce literature on this uncommon cause of acquired CHS.
ROLE OF RADIOGRAPHIC EVALUATION IN TREATMENT PLANNING FOR PATIENTS WITH MISSING UPPER LATERAL INCISORS
Authors: Korobov P.S. , Kuroedova V.D. , Vyzhenko Ye.Ye.
Published: May 2023

One of the dental conditions, which require a complex approach to diagnosis and treatment, is adentia of permanent upper lateral incisors that significantly affects the appearance of an individual regardless of gender.

The purpose of the study is to identify the prevalence of adentia of permanent upper lateral incisors and to evaluate the accompanying factors that influence the choice of treatment strategy.

A total of 1007 orthopantomograms of patients with malocclusions were analyzed, and 42 patients aged 5–20 years who had no permanent upper lateral incisors were selected. The following factors were taken into account: gender, age, type of adentia, space in the place of missing incisors, presence of rudimentary and supernumerary teeth, other missing teeth, and the presence of the third upper and lower molars, location of permanent canines and their rudiments.

The results of our study demonstrate the prevalence of adentia of permanent upper lateral incisors is 4.17%. Symmetrical or bilateral adentia of lateral incisors is more common and detected in 64.3% of the patients. The presence of space in the dentition in the area of ​​missing upper lateral incisors is found in 64.3% of patients.

Thus, in the presence of preserved temporary lateral incisors, diastemas, additional dentitions that contribute to orthodontic correction in creating a full-fledged place for the restoration of the tooth row defect in the area of ​​the lateral incisors, the replacement of missing teeth by implant placement or the replacement of the defect with non-removable aesthetic orthopaedic structures is recommended. If there is no free space in the dentition due to the displacement of the canines towards the direction of the defect, the transformation of the crown part of the canines by applying restoration technique can be recommended. Determining the peculiarities of treatment planning for adentia of the lateral incisors, taking into account the occlusal relations, seems to be promising task for further research.
DIAGNOSIS AND TREATMENT OF ODONTOGENIC PHLEGMONS OF THE ORAL FLOOR AND NECK
Authors: Steblovskyi D.V.
Published: May 2023

The treatment of odontogenic phlegmons of the maxillofacial area is still remaining an urgent problem of oral and maxillo-facial surgery due to the steady increase in their frequency, tendency to generalization of the process and adverse consequences. In this regard, there is a constant search for ways to elevate the effectiveness of managing patients with odontogenic phlegmons of the maxillofacial area, to elaborate new technologies for diagnosis, surgical and medical treatment approaches and to put them into practice. The purpose of this study is to analyze the methods of diagnosis and treatment outcomes among patients with phlegmon of the oral floor and neck based on the records of the maxillofacial department. Materials and methods. We analyzed 71 case histories of phlegmon of the oral floor and neck in patients who received treatment at the maxillofacial department from 2017 to 2022 year. The analysis reveals that the primary cause behind the occurrence of deep phlegmons in the oral floor and neck was odontogenic inflammatory processes, accounting for 37 cases; tonsillogenic lesions accounted for 9 cases, foreign bodies of the esophagus accounted for 12 cases, and adenophlegmons accounted for 13 cases. 12 patients out of 71 underwent tracheotomy followed by the intubation through a tracheostomy. All patients experienced urgent surgical intervention, including dissection and drainage of the tissue spaces in the oral floor and neck. Due to the unique structure of the fibrous spaces in the neck and the high hydrophilicity of mediastinal tissues, wide incisions were made on one or both sides of the neck to ensure adequate drainage and treatment with antiseptic solutions. Following wound cleansing, secondary delayed sutures were applied for a period of 11-18 days. Adequate medical therapy was provided to patients from the time of admission to the hospital until clinical recovery. Microbiological examination of the exudate from the wound in 54 patients revealed various pathogens, while no growth of microflora was observed in 17 patients. The isolated microflora included hemolytic streptococcus in 20 patients, various types of staphylococci in 12 patients, mixed flora in 14 patients, and anaerobes in 8 patients, all of which were identified as causative agents of purulent-septic processes. Nevertheless, a high frequency of purulent-necrotic lesions in the cellular spaces of the oral floor and neck persists, and can result in fatal consequences in some cases. The use of modern, highly effective diagnostic tools, such as computed tomography and magnetic resonance imaging, can aid in early diagnosis and determine the indications and volume of surgical intervention required for phlegmon formation.
ASSESSMENT OF THE STRESS AND METABOLISM LEVELS BY USING ELECTRO-PHOTONIC EMISSION ANALYSIS METHOD IN UKRAINIAN MILITARY PERSONNEL AFTER FRONTLINE SERVICE
Authors: Nevoit G.V. , Korpan A.S. , Nastroga T.V. , Кіtura O.E. , Sokolyuk N.L. , Lyulka N.A. , Potiazhenko М.М.
Published: May 2023

This study aims to explore the potential of the Electrophotonic Emission Analysis (EPEA) method as an instrumental approach for studying stress in biomedical research. Specifically, the study focuses on assessing the stress levels of Ukrainian military personnel returning from the front using the EPEA method. Materials and methods: A total of 96 individuals participated in this open, non-randomized, exploratory, non-controlled, comparative study. Among them, 26 were military personnel, while the rest belonged to the comparison groups. The EPEA analysis was conducted using a certified hardware and software measuring device called Bio-Well 2.0 (United States). Results: The study found a significant decrease (p<0.0001) in energy levels, with both the military personnel group (41±4.25 J) and the functionally healthy individuals group (57.38±20.78 J) showing similar results. Among the participants, 62% of military personnel and 95% of patients with non-communicable diseases demonstrated optimal energy levels, while 38% and 5% respectively showed reductions. The stress levels measured were 3.69±0.62 cu for military personnel, 3.69±0.62 cu for functionally healthy individuals, and 3.99±1.17 cu for patients with non-communicable diseases. Conclusions: The EPEA method proved effective in instrumentally detecting increased levels of stress and anxiety in 96% of military personnel, 93% of functionally healthy individuals, and 87% of patients with non-communicable diseases in the study. It is of fundamental importance for scientific and systemic medicine to establish that changes in biophoton emission can be observed in patients with non-communicable diseases, including military personnel. Significant differences in total energy levels were found between patients and functionally healthy individuals, with EPEA results showing 41±4.25 J and 43.86±4.87 J respectively for patients and functionally healthy people (p<0.0001). Electro-photonic emission analysis is a promising, valid, accessible instrumental method for biomedical research.
EFFECT OF ORTHODONTIC TREATMENT OF GENERALIZED PERIODONTITIS ON ORAL HYGIENIC STATUS
Authors: Batig I.V. , Borysenko A.V.
Published: May 2023

Orthodontic treatment of patients with generalised periodontitis can have a negative impact on the periodontium. Removable orthodontic appliances have a lesser impact on the periodontium. Considering such details of orthodontic treatment for patients with generalized periodontitis, it is critical to start orthodontic treatment as early as possible, when significant manifestations of traumatic occlusion and pronounced displacements of teeth have not developed yet.

The study aimed to determine the effectiveness of early orthodontic treatment using removable orthodontic appliances in patients with generalized periodontitis and its effect on the hygienic status of the periodontium. The study involved 40 adolescents (18-35 years) with generalized periodontitis who had displaced upper front teeth. Removable orthodontic appliances and individual retainers were used for orthodontic correction, and the patients underwent a comprehensive examination of the periodontium to assess their hygienic indices during the course of treatment.

The assessment of the periodontal tissues shows that almost all patients had an inflammatory process in their periodontal tissues. Previously, the patients had undergone Phase 1 integrated treatment for generalized periodontitis. One month after the beginning of the orthodontic correction, there was certain deterioration in the periodontal condition. However, following the completion of orthodontic treatment, the hygienic condition of the periodontium improved.

The study concluded that the combination of periodontal disease and tooth displacement requires comprehensive treatment using orthodontic methods. While the use of orthodontic treatment led to some deterioration in the periodontal condition, appropriate correction of drug treatment and rational oral hygiene practices can compensate for this.
Female Criminality in Eighteenth-Century Russia: Formulating a Research Problem
Authors: Vidnichuk Anastasia
Published: May 2023

Historians argue that the Modern Era was a turning point for the female population of European countries. The Renaissance, the Reformation, the Scientific Revolution and other major events and processes changed gender roles and social customs. To trace the qualitative characteristics of these changes, scholars examine different areas and aspects of women's lives in the past: family, sexuality, work, religion, and crime. The history of female criminality in Europe is now a well-developed and highly relevant field of research. In this article the author analyses Western historiography on the subject, identifies peculiarities of the historical context, sources and methods of processing them, and outlines possible approaches to the study of female criminality in modern Russia. The study of female criminality in eighteenth-century Russia is not only possible but also very promising. Nevertheless, scholars need to take into account the difference between the Russian and European historical contexts, as well as the nature of the sources. If properly approached, the study of female criminal behaviour in Russia and its comparison with European experience offers the historian an opportunity to look at Russian society and government in the period in question through new perspectives.
MODEL PENGAWASAN DEWAN KEHORMATAN PENYELENGGARAAN PEMILIHAN UMUM (DKPP) DALAM PENYELERANGGARAAN PEMILU BERBASIS PARTISIPATIF MASYARAKAT
Authors: Kholik Saeful
Published: May 2023

This article aims to find the form or model of supervision of the honorary board for the implementation of general elections (DKPP) in the implementation of community-based elections. Given the reality that there are still many community activities that cannot be accommodated, this is caused by the absence of an explicit model or arrangement of the community reporting process. Therefore, this article identify the following problems: 1. What is the model of Supervision of the Honorary Council for the Implementation ofGeneral Elections (DKPP) in organizing elections based on community participation, 2. What is the position of the authority and authority of the DKPP in the positive legal perspective in Indonesia? The research method used is juridical-normative, which is a way of validating a problem through an approach to norms, principles, and rules that exist in society. Based on the findings, it explains that the community participates in maintaining, controlling, and even being part of the implementation of general elections or regional head elections, and explains the position of the DKPP which has a vital position and function to maintain justice for election organizers or participants who are suspected of having committed violations of the code of ethics.
TANGGUNGJAWAB HUKUM DOKTER TERHADAP PASIEN DI KAMAR BEDAH
Authors: Arifin Jajang
Published: May 2023

The relationship between doctors and patients has been going on for a long time. A doctoris considered to be someone who gives treatment to people who need it. The legalrelationship between doctors and patients begins with a paternalistic vertical relationshippattern like father and son which departs from the principle of "Father knows best" wherea doctor is considered to be more aware and able to treat the disease suffered by thepatient. The position of doctors is higher than the position of patients and doctors have animportant role in their development. When viewed from the relationship between thedoctor and the patient, the doctor as a professional, with his education and experience isexpected to be able to use his knowledge carefully and responsibly so that he does notbecome negligent, while a patient with a weak position, does not know whether the actionstaken by the doctor are correct or not, can trust and leave the measures for his health tothe doctor, based on the information obtained from the doctor. Such a pattern ofrelationships between doctors and patients has gradually shifted towards a moredemocratic one, namely a horizontal contractual relationship or Joint participation.
Identification of metabolic biomarkers for diagnosis of epithelial ovarian cancer using internal extraction electrospray ionization mass spectrometry (iEESI-MS)
Authors: Li Jiajia , Wang Zhenpeng , Liu Wenjie , Tan Linsheng , Yu Yunhe , Liu Dongzhen , Wei Zhentong , Zhang Songling
Published: May 2023

BACKGROUND: Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies. The poor prognosis of EOC is mainly due to its asymptomatic early stage, lack of effective screening methods, and a late diagnosis in the advanced stages of the disease. OBJECTIVE: This study investigated metabolomic abnormalities in epithelial ovarian cancers. METHODS: Our study developed a novel strategy to rapidly identify the metabolic biomarkers in the plasma of the EOC patients using Internal Extraction Electrospray Ionization Mass Spectrometry (IEESI-MS) and Liquid Chromatography-mass Spectrometry (HPLC-MS), which could distinguish the differential metabolites in between plasma samples collected from 98 patients with epithelial ovarian cancer, including 78 cases with original (P), and 20 cases with self-configuration (ZP), as well as 60 healthy subjects, including 30 cases in the original sample (H), 30 cases in self-configuration (ZH), and 6 cases in a blind sample (B). RESULTS: Our study detected 880 metabolites based on criteria variable importance in projection (VIP) > 1, among which 26 metabolites were selected for further identification. They are mainly metabolism-related lipids, amino acids, nucleic acids, and others. The metabolic pathways associated with the differential metabolites were explored by the KEGG analysis, a comprehensive database that integrates genome, chemistry, and system function information. The abnormal metabolites of EOC patients identified by IEESI-MS and HPLC-MS included Lysophosphatidylcholine (16:0) [Lyso PC (16:0)], L-Phenylalanine, L-Leucine, Phenylpyruvic acid, L-Tryptophan, and L-Histidine. CONCLUSIONS: Identifying the abnormal metabolites of EOC patients through metabolomics analyses could provide a new strategy to identify valuable potential biomarkers for the screening and early diagnosis of EOC.
Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression
Authors: Mosaad Hala , Ahmed Mona Mostafa , Elaidy Mostafa M. , Elfarargy Ola M. , Abdelwahab Mai Mohamed , Abdelnour Hanim M.
Published: May 2023

BACKGROUND: Colorectal cancer (CRC) is the most common malignant tumor of the gastrointestinal tract with unfavorable prognosis. Therefore, novel biomarkers that may be used for new diagnostic strategies and drug-targeting therapy should be developed. OBJECTIVES: To investigate the expression of miR-29b in CRC and its association with ETV4 and cyclin D1 expression. Moreover, the current work aims to investigate the association between them and the clinicopathological features of CRC. METHODS: The expression of miR-29b and ETV4 (by qRT-PCR) and ETV4 and cyclin D1 (immunohistochemistry) was investigated in 65 cases of colon cancer and surrounding healthy tissues. RESULTS: MiR-29b down-regulated and ETV4 and Cyclin D1 up-regulated significantly in colon cancer tissues compared to normal nearby colonic tissues. In addition, significant associations between ETV4 and cyclin D1 expressions and progressive stage and lymph node (LN) metastasis (P< 0.001 for each) were found. Furthermore, there was a negative correlation between miR-29b gene expression and ETV4 gene expression (r=-0.298, P<0.016). CONCLUSION: Down-regulation of miR-29b and over-expression of ETV4 and cyclin D1 may be utilized as early diagnostic marker for development of colon cancer. ETV4 and cyclin D1 correlate with poor prognostic indicators and considered as a possible target for therapy in colon cancer.
U.S. state health agencies and organizational learning: An exploratory analysis of website accessibility during COVID-19
Authors: Allgood Michelle , Frandell Ashlee
Published: May 2023

The COVID-19 pandemic has exposed the inaccessibility of government information and communication technologies (ICTs) for members of the disability community. Organizational learning around ICT accessibility can be impacted by factors influencing strategies and assumptions or values and norms. Using data collected over two time periods in 2021, we study how the accessibility of US state health agencies COVID-19 information and vaccine websites improve over time. We examine how time, state policies, and partisanship influence organizational learning around website accessibility. Our analysis determines that the longer a COVID-19 related website exists on the Internet, the less accessible the website. We also find that more extensive internal state accessibility policies are more correlated with websites that meet fundamental accessibility requirements. Additionally, we find that partisanship plays an unexpected role in meeting fundamental accessibility demands, although both state policies and politics do not influence if an ICT meets the best practices standards of accessibility. Our paper initiates a discussion around the factors that influence organizational learning about government website accessibility and points to future research questions where the primary ICT function is not influenced by a rapidly evolving pandemic.
APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer’s Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation
Authors: Liu Jieyi , Xie Yirong , Lu Yao , Zhao Zhiqiang , Zhuang Zhixiong , Yang Linqing , Huang Haiyan , Li Hongya , Mao Zhiyi , Pi Shurong , Chen Fubin , He Yun
Published: May 2023

Background:

There is limited information about gene-environment interaction on the occurrence and the progression of Alzheimer’s disease.

Objective:

To explore the effect of environmental low-dose cadmium (Cd) exposure on the progress of Alzheimer’s disease and the underlining mechanism.

Methods:

We administered 1 mg/L, 10 mg/L cadmium chloride (treated groups), and water (control group) to C57BL/6J and APP/PS1 mice through drinking water, from one week before mating, until the offspring were sacrificed at 6 months of age. The behaviors, Cd level, blood-brain barrier (BBB) leakage, Aβ1-42 deposition, and inflammation expression were evaluated in these mice.

Results:

Mice of both genotypes had similar blood Cd levels after exposure to the same dose of Cd. The toxic effects of Cd on the two genotypes differed little in terms of neuronal histomorphology and BBB permeability. Cd caused a series of pathological morphological changes in the mouse brains and more fluorescent dye leakage at higher doses. Furthermore, the APP/PS1 mice had more severe damage than the C57BL/6J mice, based on the following five criteria. They were increasing anxiety-like behavior and chaos movement, spatial reference memory damage, Aβ plaque deposition in mouse brains, increasing microglia expression in the brain, and IL-6 higher expression in the cortex and in the serum.

Conclusion:

Low-dose Cd exposure for 6 months increases Aβ plaque deposition and BBB permeability, exacerbates inflammatory responses, and activates microglia, in APP/PS1 mice. APP/PS1 gene-environmental Cd interaction aggravates the progression of Alzheimer’s disease in mice.
Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies
Authors: Meduri Geri , Guillemeau Kevin , Daguinot Corentin , Dounane Omar , Genet Melanie , Ferrara Luigi , Chambraud Beatrice , Baulieu Etienne Emile , Giustiniani Julien
Published: May 2023

Background:

Pathological tau proteins constitute neurofibrillary tangles that accumulate in tauopathies including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and familial frontotemporal lobar degeneration (FTLD-Tau). We previously showed that the FKBP52 immunophilin interacts functionally with tau and strongly decreases in AD brain neurons in correlation with tau deposition. We also reported that FKBP52 co-localizes with autophagy-lysosomal markers and an early pathological tau isoform in AD neurons, suggesting its involvement in autophagic tau clearance.

Objective:

Our objective was to evaluate if differences in neuronal FKBP52 expression levels and subcellular localization might be detected in AD, PSP, familial FTLD-Tau, and in the hTau-P301 S mouse model compared to controls.

Methods:

Cell by cell immunohistofluorescence analyses and quantification of FKBP52 were performed on postmortem brain samples of some human tauopathies and on hTau-P301 S mice spinal cords.

Results:

We describe a similar FKBP52 decrease and its localization with early pathological tau forms in the neuronal autophagy-lysosomal pathway in various tauopathies and hTau-P301 S mice. We find that FKBP52 decreases early during the pathologic process as it occurs in rare neurons with tau deposits in the marginally affected frontal cortex region of AD Braak IV brains and in the spinal cord of symptomless 1-month-old hTau-P301 S mice.

Conclusion:

As FKBP52 plays a significant role in cellular signaling and conceivably in tau clearance, our data support the idea that the prevention of FKBP52 decrease or the restoration of its normal expression at early pathologic stages might represent a new potential therapeutic approach in tauopathies including AD, familial FTLD-Tau, and PSP.
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer’s Disease
Authors: Liu Mingxia , Li Mo , He Jing , He Yi , Yang Jian , Sun Zuoli
Published: May 2023

Background:

Alzheimer’s disease (AD) is a complex neurodegenerative disease, and increasing evidence has linked dysregulation of amino acids to AD pathogenesis. However, the existing studies often ignore the chirality of amino acids, and some results are inconsistent and controversial. The changes of amino acid profiles in AD from the perspective of enantiomers remain elusive.

Objective:

The purpose of this study is to investigate whether the levels of amino acids, especially D-amino acids, are deregulated in the peripheral serum of AD patients, with the ultimate goal of discovering novel biomarkers for AD.

Methods:

The chiral amino acid profiles were determined by HPLC-MS/MS with a pre-column derivatization method. Experimental data obtained from 37 AD patients and 34 healthy controls (HC) were statistically analyzed.

Results:

Among the 35 amino acids detected, D-proline, D/total-proline ratio, D-aspartate, and D/total-aspartate ratio were decreased, while D-phenylalanine was elevated in AD compared to HC. Significant age-dependent increases in D-proline, D/total-proline ratio, and D-phenylalanine were observed in HC, but not in AD. Receiver operator characteristic analyses of the combination of D-proline, D-aspartate, D-phenylalanine, and age for discriminating AD from HC provided satisfactory area under the curve (0.87), specificity (97.0%), and sensitivity (83.8%). Furthermore, the D-aspartate level was significantly decreased with the progression of AD, as assessed by the Clinical Dementia Rating Scale and Mini-Mental State Examination.

Conclusion:

The panels of D-proline, D-phenylalanine, and D-aspartate in peripheral serum may serve as novel biomarker candidates for AD. The latter parameter is further associated with the severity of AD.
Fuzzy topological invariants in uniform fuzzy graphs
Authors: Guan Hao , Ejaz Farukh , ur Rehman Atiq , Hussain Muhammad , Kosari Saeed
Published: May 2023

In this paper, we have defined some fuzzy topological invariants for particular types of uniform fuzzy graph. Some particular useful types of uniform fuzzy graphs are Uniform Edge Fuzzy Graph, Uniform Vertex Fuzzy Graph, Uniform Vertex-Edge Fuzzy Graph and Totally Uniform Fuzzy Graph. For each particular type we have defined different kinds of degrees in a graph in accordance with the unique nature of it. In the end, we have applied all our output results to a cellular neural fuzzy graph as an example, to verify the predicting ability of topological invariants. The aim of this paper is to define more significant fuzzy topological invariants in fuzzy graphs. Our ideas will help to create a link between fuzzy graph theory and simple (crisp) graph theory.
Multi-granulation rough approximations under normal distribution
Authors: Zhao Jie , Wan Renxia , Miao Duoqian
Published: May 2023

Multi-granulation decision-theoretic rough set effectively combines Bayesian decision approaches with multi-granulation rough set theory, and provides an important theoretical framework for studying rough set. In this paper, we explore several extensional models of multi-granulation decision-theoretic rough sets under the normal distribution of the decision loss function. Using the 3σ rule of normal distribution, we transform the decision loss of the multi-granulation decision-theoretic rough set into a set of interval values. We construct the upper and lower approximations from the optimistic, weakly optimistic, pessimistic, weakly pessimistic, optimistic-pessimistic, weakly optimistic-pessimistic, pessimistic-optimistic, and weakly pessimistic-optimistic viewpoints, and provide the decision rules of the proposed rough set models. The work in this paper brings the decision behavior based on a multi-granulation decision-theoretic rough set closer to the actual situation.
Incorporating keyword extraction and attention for multi-label text classification
Authors: Zhao Hua , Li Xiaoqian , Wang Fengling , Zeng Qingtian , Diao Xiuli
Published: May 2023

As one of the fundamental tasks in natural language processing, Multi-Label Text Classification (MLTC) is used to mark one or more relevant labels for a given text from a large set of labels. Existing MLTC methods have increasingly focused on improving classification effectiveness by fusing the correlations of labels. Still, the research suffers from difficulties in comprehensively extracting text features and distinguishing similar labels. This paper proposed a multi-label text classification model based on keyword extraction and attention mechanism. The model proposed using keywords to represent labels, adopting both self-attention and interactive attention mechanisms (between labels and text) to extract text features and create text vectors. Finally, fusing text vectors as the classifier’s input. Experiments were conducted on two public datasets and a self-built dataset of illegal advertisements. The experimental results showed that the keyword-based label representation approach proposed in this paper can better obtain label semantics, avoid noise and improve the performance of the multi-label text classification.