bluuebunny/crossref_metadata_2025 huggingface dataset:
Foetal phenotype of Maat-Kievit-Brunner type Ohdo syndrome
Authors: Ashutosh Gupta , Anjila Aneja , Neena Bahl , Rupam Arora , Renu Raina Sehgal , Pankaj Saini
Published: November 2021

MED12 is a member of large Mediator complex; has a very crucial and central role in RNA polymerase II transcription; regulating cell signals involved in growth, development and differentiation. Different MED12 mutations may have different clinical presentation representing an allelic disorder. Maat-Kievit-Brunner (MKB) type Ohdo syndrome; has a typical facial features comprising of blepharophimosis, ptosis, long flat philtrum with thin vermilion, micrognathia with microstomia, scrotal hypoplasia with cryptorchidism, joint hypermobility with clinodactyly with overriding toes, A primigravida on antenatal ultrasound was detected to have growth restriction, corpus callosal dysgenesis, syndactyly and suspected ambiguous genitalia. Invasive testing and exome sequencing revealed hg19chrX:MED12:c.2315A>G: (p.Lys772Arg);MED12(NM_005120.3):c.2315A>G: (p.Lys772Arg) leading to provisional diagnosis of X linked Ohdo syndrome with an overlap with FG. Missense mutation was classified to be PM2; PP3 (ACMG) Clinical presentation, phenotype and mutational analysis led to provisional diagnosis of X linked Ohdo syndrome. Maat-Kievit-Brunner type of Ohdo syndrome is a rare condition and this is probably the first case describing foetal phenotype of MKB type of Ohdo syndrome.
Mammographic Breast Densities among 200 Nigerian Females in Sokoto, North Western Nigeria
Authors: Baba SULE Muhammad , Muhammad Shamaki Amina , Sule Ahmed SA’IDU , Mohammed Ma’aji SADISU , Garba Haruna YUNUSA , Ibrahim Haruna GELE , Yakubu Bababa SHIRAMA
Published: November 2021

Background: Breast density has been reported to be an independent predictor of breast cancer risk. Women with highest mammographic breast density may have four to six fold increased risk of developing cancer. Aim and Objective: This study is aimed at evaluating the various forms of breast densities following screening and diagnostic mammographic examination. Materials and Methods: From December 2010 and November 2012, 200 females had mammographic breast examination. Seventy-seven (77) females had routine screening mammography while 123 had diagnostic mammographic examination in the department with the General Electric (GE) Alpha-RT machine with model number MGF-101(manufactured 2010). All the subjects had to fill a mammographic form consisting of variables like age, sex, occupation, family history of breast cancer, tribe, contraception, parity, and caffeine consumption, history of surgical intervention (lumpectomy, biopsy and/or mastectomy), previous mammography and last child birth. MLO and CC views were done for the breast examination though additional views were occasionally employed. Results: Breast density decreases with increase in age of the female subjects and breast lesions are better detected following mammography on fatty or less dense breast.
Adverse Event Reporting in Patients with Thyroid Dysfunction Treated with Levothyroxine in Armenia. A Cross Sectional Pilot Study
Authors: R. Petrosyan Tigran , Imad Kanaan Nihad
Published: November 2021

Background and Aim. Currently two forms of levothyroxine are presented in pharmaceutical market of Armenia: Euthyrox and L-thyroxine. Local physicians have a choice of two different levothyroxine preparations, each of them with different dosage from 25 to 150mg. Oral levothyroxine (LT4) is the standard therapy for patients with hypothyroidism. The purpose of this report is to describe the adverse outcomes reported by endocrinologists, the frequent prescribers of levothyroxine, practicing in Armenia and to compare the rate of adverse reactions with data from different international research reports. Materials and methods. A Pharmacovigilance questionnaire was developed based on the literature reports to assess potential adverse events attributable to the use of levothyroxine products. Statistical Analysis Results were collected, interpreted and presented as percentages. Results. The study was with a cross-sectional design conducted in medical centers of Armenia using convenience sampling. The respondent parents of patients were selected using simple random sampling. Of the total 56 survey responses received, the majority 35 [63%]) reported no adverse events. The adverse effects were due to new or unexpected symptoms in 2 (25%), a TSH change alone in 1 (12%), or both in 6 (75%). Most the symptoms (5/8 [65%]) were consistent with thyrotoxicosis, arrhythmias were documented in three cases, while 35% (3/8) of cases had symptoms typical of hypothyroidism. Conclusions. Clinicians prescribing Euthyrox and L-thyroxine should be reminded that these products are from different manufacturers and patients/physicians should be made aware of all possible adverse reactions results, which could be different for these two products.
In clear water no fish can live. Water purification promote global warming, decline of countries
Authors: Ozaki Shoichiro
Published: November 2021

Carbon dioxide CO2 increasing 2 ppm yearly since developed countries started elimination of NOx and elimination of NP. Global warming is happening by the decrease of CO2 assimilation from insufficient supply of NP fertilyzer. Developed countries hated NOx and NP and are eliminating NOx and NP. Japan is criticized as increasing much CO2. Japan is eliminating NOx,NP completely using much electricity producing 2 billion tone CO2 for the elimination of NOx and NP. Fish production of Japan dropped to 10%. GDP do not increase. If developed countries stop elimination of NOx,NP . CO2 assimilation is activated. Production of grain and fish increase. DGP will increase and global warming will stop.
Zinc (?)-immune pediatric virucidal activities for 2019-nCoV prevention and therapeutic effects of COVID-19 bronchitis and pneumonia
Authors: Tsuneo Ishida Sci.
Published: November 2021

Zinc (Ⅱ)-immune pediatric virucidal activities for children with 2019-nCoV prevention and COVID-19 bronchitis and pneumonia are discussed, and these Zn2+-immune pediatric virucidal effects result in the following. Zinc intakes by zinc induced immunity are required 3 mg/day for 7 month to 3 years, 5 mg/day for 4～ 8 years, and 8 mg/day for 9 ～13 years in children. Zinc supplementation have been assessed, from 15 mg to 140 mg/week, with the upper range exceeding the recommended daily infection (RDI) for children of 2 mg/day for children less than one year of age and up to 7 mg/day for children between 1 to 3 years. Zinc induced pediatric preventing respiratory 2019-nCoV is required that supplementation with zinc gluconate 20 mg in Zn deficient children resulted in a nearly twofold reduction of acute lower respiratory infections as well as the time to recovery. Zinc supplementation in children is associated with a reduction in the incidence and prevalence of pneumonia. Preventing 2019-nCoV pneumonia is required that zinc supplementation alone (10 to 20 mg) for more than 3 months significantly reduces in the rate of pneumonia. Prophylactic zinc supplementation for two weeks may reduce the morbidity due to acute lower respiratory infections. Zinc gluconate supplement may result in significant reduction in respiratory morbidity among children with acute lower respiratory infections. In addition. as serum zinc level of Acute Respiratory Infection (ARI)-children was very low, higher zinc concentration treatments as low sociodemographic factors, poor nutritional status and male children were prevalently associated with higher incidence of acute respiratory infections. Adjuvant treatment with 20 mg zinc/day accelerates recovery from severe pneumonia in children. Primary outcome was recovery from pneumonia and 30 mg/day of zinc supplementation reduces pneumonia in children with chronic kidney disease (CKD). Zinc supplementation + Chloroquine (CQ)/hydroxychloroquine (HCQ) may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. The serum zinc level returned to a normal level (median, 53.20 μmol/L) on day 12±2 in the treatment. There was no statistical difference in the pediatric critic illness score, lung injury score, length of hospital stay, and duration of mechanical ventilation between the zinc treatments. The oxidative stress in pediatric diseases causes an oxidative burst that results in a respiratory burst and rapid ROS production. Thus, zinc pediatric intake may be required to be effective range 10～20 mg/d for 2019-CoV prevention, 10～30 mg/d for reduction of COVID-19 bronchitis, and 20～30 mg/d for recovery from COVID-19 pneumonia, in which Zn2+ could bind with viral surface proteins by Zn2+ions-centered tetrahedrally coordination pattern.
Poor COVID 19 Pandemic Waste Management Outcome in Nigeria: A Possible Potential Public Health Threat and Promoter of Community Transmission
Authors: Obioma Azuonwu , Christian Ahiakwo , Promise Chijioke Egba
Published: November 2021

Introduction The COVID-19 pandemic outcome which is an emerging infectious disease that potentially originated from Wuhan in China has seen an upsurge of cases and deaths globally over time. One of the consequences found in the course of the management of these viral pandemic involves the massive production and usage of different myriad of medical supplies to meet up the increasing demands by health workers, patients and the public. This trend has resulted in the proliferation of medical wastes against a backdrop of poor waste management outcome especially in Nigeria. Aim The aim of this article borders on bringing to light the effects of improperly managed medical wastes, and the risks it poses to human health and the environment at large. Furthermore also, to outline various types of medical wastes and the guidelines associated with their disposal, especially those associated with management of COVID-19 pandemic saga. Method/Methodology The study approach follows the systematic review of peer-reviewed published articles as well as online publications and articles derived from various databases with search keywords relevant to the topic of discourse. Findings and Results Findings from this study show that the coronavirus disease of 2019 has spread widely globally with massive socio-economic and socio-cultural consequences. Over time there has been a progressive increase in cases and deaths due to Covid-19 in Nigeria and most other countries. The management of COVID-19 pandemic has resulted in the proliferation of medical wastes. Medical wastes are those generated from the use of medical supplies in the course of healthcare delivery and disease prevention such as hand gloves, facemasks, and hazmat suits etc. Medical wastes legislations that support the proper disposal of medical wastes in Nigeria and most other developing nations have been very weak and have failed to achieve the desired results, with high incidences of infectious diseases such as HIV and Hepatitis still being transmitted through improperly disposed of wastes. Therefore improperly waste disposal may probably serve as a very potent means of community transmission of COVID-19 transmission, if not handled in good time especially the freshly disposed materials Conclusion and Recommendation While the generation of massive wastes is being seen in this COVID-19 pandemic period, it may be unavoidable that there could be re-infection of subjects from improper medical waste disposal strategies. Thus, it is pertinent that relevant regulations are put in place, enforced and monitored to ensure that improperly managed wastes do not form another avenue for widespread of the virus in our communities. It is also very necessary to organize massive campaigns aimed at creating enough public awareness of the risks associated with medical wastes and on the need for proper disposal especially COVID 19 associated waste materials.
Re-Print: Developing and then Confirming a Hypothesis Based on a Chronology of Several Clinical Trials: A Bayesian Application to Pirfenidone Mortality Results
Authors: Lin Zhengning , A Berry Donald
Published: November 2021

Designing a study for independent confirmation of a treatment effect is sometimes not practical due to required large sample size. Post hoc pooling of studies including those for learning purposes is subject to selection bias and therefore generally not suitable for confirmation of a treatment effect. We propose a Bayesian approach which calibrates the role of prior information from historical studies for learning and confirming purposes. The amount of prior information to be combined with current study data for the purpose of hypothesis confirmation depends on the overall strength of prior information for hypothesis generation. The method is illustrated in the analysis of mortality data for the pirfenidone NDA. The Bayesian analysis provides a formal method to calibrate the role of information from historical evidence in the overall interpretation of results from both historical and concurrent clinical studies. The increased efficiency of using all available data is especially important in drug development for rare diseases with serious consequences, where limited patient source prohibits large trials, and unmet medical needs demand rapid access to treatment options.
Electrophysiological procedures for the use of the RPC: without hindrance and negligible radiation
Authors: Ilya Matvei , Gleb Vladislav
Published: November 2021

Background: Fluoroscopy is the main visualization technique for EP procedures. A radiation protection cabin (RPC) shielded with 2 mm lead-equivalent walls was tested as an alternative protection tool (Cathpax®, Lemer Pax). Methods: To assess the scattered radiation to the operator inside the RPC an electronic personal dosimeter (EPD; Mk2, Thermo Electron) was placed at the neck level of the operator. A second EPD was located outside the RPC at 150 cm height from the floor, to record the presumable head radiation dose. Results: Radiation doses were measured in a total of 138 consecutive patients (age 54±16 yrs, BMI 28±5 kg/m2 (18-45), 64% male) undergoing a variety of ablation procedures (SVT=75, AFL=32, AF=17, VT=14). Median fluoroscopy time was 39 min (7-140), the cumulative dose-area product (DAP) 4702 cGy.cm2 (493-65620). Doses outside the RPC showed a median of 135 µSv (1-4881). Doses inside the RPC were detected only at sensitivity threshold or background levels (mean 0.2SD0.7 µSv, median 0.0, range 0-4). The dose reduction to the operator was highest for AF ablations (354 vs 0.5 µSv, respectively; p<0.001). The total accumulated dose outside the RPC was 37883 µSv for all 138 procedures, whereas for the protected operator inside only 30 µSv. Conclusions: There were highly concordant low dose values measured for the operator inside the RPC in comparison to high doses outside the RPC. The use of a RPC represents a major benefit over a lead apron and contributes to a significant dose reduction as low as reasonably achievable (ALARA principle).
Unstable odontoid fractures: technical appraisal of anterior extrapharyangeal open reduction internal fixation for irreducible unstable odontoid fractures. Patient series
Authors: Patkar Sushil
Published: November 2021

BACKGROUND

Displaced odontoid fractures that are irreducible with traction and have cervicomedullary compression by the displaced distal fracture fragment or deformity caused by facetal malalignment require early realignment and stabilization. Realignment with ultimate solid fracture fusion and atlantoaxial joint fusion, in some situations, are the aims of surgery. Fifteen such patients were treated with direct anterior extrapharyngeal open reduction and realignment of displaced fracture fragments with realignment of the atlantoaxial facets, followed by a variable screw placement (VSP) plate in compression mode across the fracture or anterior atlantoaxial fixation (transarticular screws or atlantoaxial plate screw construct) or both.

OBSERVATIONS

Anatomical realignment with rigid fixation was achieved in all patients. Fracture fusion without implant failure was observed in 100% of the patients at 6 months, with 1 unrelated mortality. Minimum follow-up has been 6 months in 14 patients and a maximum of 3 years in 4 patients, with 1 unrelated mortality.

LESSONS

Most irreducible unstable odontoid fractures can be anatomically realigned by anterior extrapharyngeal approach by facet joint manipulation. Plate (VSP) and screws permit rigid fixation in compression mode with 100% fusion. Any associated atlantoaxial instability can be treated from the same exposure.
HISTOGENESIS AND MOLECULAR PECULIARITIES OF TERMINAL DUCT IN THE WOMAN'S MAMMARY GLANDS
Authors: Nikolenko D.E.
Published: November 2021

The development of a woman's mammary glands occurs during the fertile age. It is during this period that the glands are subject to morpho-functional changes in the form of proliferation and differentiation of the epithelium in the parenchyma and elements of the stroma as response to the action of many stimulating physiological factors of the body. There changes have a tendency to be repeated several times during the woman's reproductive age. There is enough in-depth knowledge about the object of the cyclic effect of sex hormones in the woman's mammary glands. This study will expand knowledge about the important morphological state of the terminal ducts of the mammary glands before pregnancy and childbirth that can be of great importance in determining the histogenesis of possible pathomorphological changes in the gland of a dyshormonal and neoplastic nature. The aim of the study was to investigate the molecular characteristics of the parenchyma of the terminal ducts of the mammary glands of a non-pregnant woman of reproductive age. The study was carried out on autopsy material of 192 micro-incisions of breast tissue samples from 8 women who died of infectious diseases. Karyometry with the definition of the logarithm of the volume of the nuclei of the parenchymal elements in the structures of the terminal ducts was performed; histological, histochemical and immunohistochemical research methods were applied. The study identified histogenetic series of the epithelial lining in the parenchyma of the terminal ducts of the mammary gland; applying immunohistochemical markers enabled cytotyping of the epithelial elements of these ducts, as well revealing certain functions of the terminal ducts of the mammary glands before pregnancy and childbirth.
ROLE OF STUDENTS’ RESEARCH ACTIITY IN FOSTERING PROFESSIONAL COMPETENCE AT THE DEPARTMENT OF PATHOPHYSIOLOGY OF POLTAVA STATE MEDICAL UNIVERSITY
Authors: Nazarenko S. M. , Kostenko V. A. , Akimov O. Ye. , Denysenko S. V. , Solovjova N. V.
Published: November 2021

Student research activity is one of the most important forms of the education and the driving force of quality assurance activities. Ukraine has developed a regulatory and legal framework that ensures high-quality research work, which should meet the needs of future specialists in intellectual and professional development and increase their professional competence. The involvement in research work requires, first of all, gaining deep theoretical and practical knowledge in medicine, well-designed extra-curricular activities to guide students in their mastering methodology of scientific research and developing research skills, and university promotion. The experience of Poltava State Medical University convincingly proves that the most effective means of improving the quality of training is the regular active involvement of students in research activity. The role of scientific knowledge in higher education is decisive, since the active participation of the teaching staff in fostering research skills makes it possible to demonstrate the latest scientific achievements and their practical application. Structured research activities, woven into the medical school curriculum provide an opportunity to evince the intellectual potential of both students and educators, to contribute to deeper investigation of medical problems, to master the methods of scientific investigation, and to realize the importance of such activity in increasing one's competitiveness in the labour market. This approach also contributes to better comprehension of professional information, to develop mindset associated with high professionalism.

Pathophysiology as a discipline is at the junction of theoretical and clinical disciplines that serves as a wide background to meet the diversity of students’ scientific demands and interests. Involving students into structured research activities not only promotes gaining special knowledge, but also builds up ethical and deontological foundations of future successful medical research career; enhances team spirit and cooperation between students and educators. This interaction enables in clearly stating their focus and research question, engaging in an adequate critical discussion of the strengths and weaknesses of the study methods, and offering conclusions that are properly qualified in the scope given the evidence gathered and analyzed. This department is proud to maintain a high university rank on student research results performance among the non-clinical departments. The culmination of knowledge in this developmental trajectory can reinforced and extend other aspects of high quality training.
SLEEP DISORDER IN CHILDREN IN INTENSIVE CARE UNIT: CURRENT STATE OF PROBLEM AND PROSPECTS FOR FUTURE RESEARCH
Authors: Tsvirenko S.M. , Adamchuk N.M. , Malakhova V.M. , Melashchenko O.I. , Zhuk L.A.
Published: November 2021

Insomnia is one of the most common clinical syndromes of somnological disorders, including any sleep disorders under sufficient time and appropriate sleeping conditions. Significant sleep disturbances are common in children who enter the intensive care unit. Between 18 and 65 per cent of children aged between 2 and 18 hospitalized in the intensive care unit have a clinical condition of acute confusion, better known as delirium. Sleep fragmentation, reduction of total sleep time, lack of slow, deep sleep and rapid sleep, and shift of sleep time are changes that can also act as insomnia triggers. Their presence worsens the course of the disease in the patient, prolongs the hospital stay, and increases the risk of complications and lethality. Circadian sleep disorder is a condition that requires close monitoring. Although insomnia therapy approaches are not yet reliable, early diagnosis of insomnia can reduce the duration of the delirium. Sleep assessment includes questionnaires and diaries. However, it was recognized that, despite the difficulties in implementing and interpreting polysomnography, it was still a gold standard for more accurate detection of changes in sleep phases and the difference between normal and abnormal sleep. In the absence of a polysomnograph, it is permissible to use a prolonged video assisted EEG. The inventive multimodal video-assisted monitoring method makes it possible to diagnose sleep disorders, pain syndrome and differential diagnosis of apnoea with cardiac and conductivity disorders or abnormal brain activity, including the presence of sub-clinical convulsions in patients of high-risk groups using a safe and non-invasive method for analyzing trends in the total bioelectric activity of different biological structures of a child. The validation of questionnaires according to the age of the child is also an important step in the timely diagnosis of sleep disorders in older children.
ANALISA STRATEGI PENGEMBANGAN USAHA GUNA MENINGKATKAN KEUNTUNGAN PADA UNIT SIMPAN PINJAM KUD DASTRA KINALI DENGANMENGGUNAKAN PORTOFOLIO BCG (BOSTON CONSULTING GROUP)
Authors: Syafrinaldi Syafrinaldi , Yuliza Mai
Published: November 2021

Penelitian ini bertujuan untuk mengetahui Analisa Strategi Pengembangan Usaha Guna Meningkatkan Keuntungan Pada Unit Simpan Pinjam KUD Dastra Kinali Dengan Menggunakan Portofolio BCG (Boston Consulting Group). Pada penelitian ini metode yang digunakan adalah, dengan menggunakan metode  Analisis Domain , Analisis Taksonomi, Analisis Komponensial , Analisis Tema Budaya .Hasil Analisa yang dilakukan dilihat dari matrik BCG dapat diketahui bahwa posisi KUD Dastra laporan keuangan KUD Dastra pada Unit Simpan Pinjam terletak pada Kuadran STAR  dalam arti kata Sisa Hasil Usaha KUD Dastra berada pada pertumbuhan yang cepat dan bagus. Garis vertikal matrik BCG yang melambangkan pertumbuhan peluang sisa hasil usaha KUD Dastra sudah tergolong tinggi karena ukuran pertumbuhan sisa hasil usaha KUD Dastra berdasarkan dari matrik BCG adalah 100% /Tahun. Sedangkan dari perhitungan dan pembahasan dari data yang didapat pertumbuhan KUD Dastra adalah 88.2 % jadi jika dinilai dari BCG pertumbuhan KUD Dastra sudah baik. Peluang KUD Dastra yang digambarkan dengan sumbu horizontal pada matrik BCG jika diterapkan ke KUD Dastra maka dapat dinilai dalam persentase sebesar 15.3 % angka ini tergolong  besar untuk satu unit Simpan Pinjam. Bisa dikatakan KUD Dastra mempunyai keunggulan yang kompetitif dalam meningkatkan peluang pertumbuhan KUD Dastra itu sendiri.
ANALISIS SERVICE MARKETING-MIX DAN PENGARUHNYA TERHADAP KEPUTUSAN PEMILIHAN JASA PENDIDIKAN PROGRAM PASCASARJANA
Authors: Sefnedi Sefnedi
Published: November 2021

Higher educational sector plays a major role on Indonesia’s human development. Therefore, higher education market faces keen competition including in west sumetera. The main purpose of this study was to examine the impact of service marketing-mix on consumer’s buying decision. A total of149  feedback  reveived  from  the  162  questionnaires  distributed.  The  findings  incate  that  only dimensions of product, promotion, place, people, and process are found to have positif and significantimpact on consumer’s buying decision. However, dimension of price and physical evidence are not socrucial in explaining the variations in consumer’s buying decision.
PENGARUH ORIENTASI KEWIRAUSAHAAN TERHADAP KINERJA PEMASARAN IKM KOTA PADANG DENGAN DIFFERENTIATION STRATEGY SEBAGAI VARIABEL INTERVENING
Authors: Usvita Mega
Published: November 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis : 1) Pengaruh orientasi kewirausahaan terhadap kinerja pemasaran IKM Kota Padang, 2) Pengaruh orientasi kewirausahaan terhadap differentation strategy terhadap kinerja pemasaran IKM Kota Padang, 3) Pengaruh differentiation strategy terhadap kinerja pemasaran, 4) Pengaruh differentiation strategy berperan sebagai variabel intervening antara orientasi kewirausahaan dan kinerja pemasaran IKM Kota Padang. Populasi penelitian ini adalah seluruh IKM Kerupuk kulit, keripik balado dan keripik peyek yang berada di kota Padang pada tahun 2010 – 2012 yang berjumlah 184 industri. Untuk pengambilan sampel digunakan metode proportional cluster random sampling yaitu penarikan sampel secara acak berdasarkan klaster dan proporsional yang didapat sampel sebanyak 126 sampel. Hasil penelitian menemukan bahwa : 1) Orientasi kewirausahaan berpengaruh positif dan signifikan terhadap kinerja pemasaran IKM Kota Padang. 2) Orientasi kewirausahaaan berpengaruh positif dan signifikan terhadap differentiation strategy IKM Kota Padang. 3) Differentiation Strategy berpengaruh positif dan signifikan terhadap kinerja pemasaran. 4) Differentiation berpengaruh positif dan signifikan sebagai variabel intervening antara orientasi kewirausahaan dan kinerja pemasaran. Kata Kunci : Kinerja pemasaran, Orientasi Kewirausahaan, Differentiation Strategy
PENGARUH PERSON ORGANIZATION FIT (P-O FIT)DAN LINGKUNGAN KERJA TERHADAP PRESTASI KERJA KARYAWAN PT. ANDALAS AGRO INDUSTRI (AAI)DI KECAMATAN KINALI KABUPATEN PASAMAN BARAT
Authors: Hamzah Nur
Published: November 2021

Penelitian ini dimaksudkan untuk melihat bagaimana PERSON ORGANIZATION FIT (P-O FIT) dan Lingkungan Kerja mempengaruhi Prestasi Kerja Karyawan. Dari hasil penelitian ini didapatkan variabel P-O FIT (X1)danLingkungan Kerja ( X2) berpengaruh signifikan terhadap Prestasi Kerja Karyawan (Y).Metode pengumpulan data yang digunakan adalah angket dan dokumentasi. Metode analisis data yang digunakan adalah analisis deskriptif dan analisis regresi linier berganda dengan menggunakan SPSS for windows release 16. Hasil Penelitian dari analisis regresi linier berganda di peroleh persamaan regresiY = 0,431 + 0.432 X1 + 0.531X2. Hasil analisis varians untuk regresi diperoleh nilai f46.051dengan tingkat signifikan sebesar 0,000. Ini berarti bahwa nilai signifikan F lebih kecil dari alpha 5 % (0,000 < 0,05. Adapun besarnya koefisien determinasi (R2) diperoleh 0,526.Hal ini menunjukkkan bahwa pengaruh P-O FIT dan lingkungan kerjaterhadap prestasi kerja karyawan sebesar 52,6% Sedangkan sisanya dipengaruhi oleh faktor lain atau sisanya 47,4% yang dipengaruhi oleh Variabel yang belum di teliti. dengan tingkat signifikan sebesar 0,000. Besarnya pengaruh P-O FIT dan Lingkungan Kerja terhadap Prestasi Kerja Karyawan, Dari Uji T yang diperlihatakan pada table Coefflcientster terlihat bahwa nilai Alfa untuk variabel P-O FIT yaitu sebasar 4,730 signifikan.Sedangkan pengaruh Lingkungan Kerja yaitu sebesar 5,785 signifikan. penelitian yang telah dilakukan dengan menggunakan sampel 86 orang Karyawan PT AAI Kab. Pasaman Barat.

Kata Kunci:P-O Fit, Lingkungan kerja dan Prestasi kerja Karyawan.
PENGARUH BUDAYA ORGANISASI DAN BEBAN KERJA TERHADAP KINERJA PEGAWAI PADA DINAS KOPERASI PERINDUSTRIAN PERDAGANGAN DAN UKM (KOPERINDAG &UKM) KABUPATEN PASAMAN BARAT
Authors: Yurasti Yurasti
Published: November 2021

Penelitian ini dimaksudkan untuk melihat bagaimana Budaya Organisasi dan Beban Kerja mempengaruhi kinerja Pegawai. Dari hasil penelitian ini didapatkan variabel Budaya Organisasi (X1)dan Beban Kerja ( X2) berpengaruh signifikan terhadap kinerja Pegawai (y) dimana koefisien regresi Berganda adalah 0,91 dengan tingkat signifikan sebesar 0,000. Besarnya pengaruh Budaya Organisasi dan Beban Kerja terhadap kinerja Pegawai, Dari Ujit yang diperlihatakanpada table Coefflcientsterlihatbahwanilai Alfa untukvariabelbudayaorganisasi yaitu sebasar 0,420 signifikan. Sedangkan pengaruh Beban Kerjayaitu sebesar 0,668signifikan. penelitian yang telah dilakukan dengan menggunakan sampel 66 orang pegawai Dinas Koperindag dan UKM Kabupaten Pasaman Barat.

Kata Kunci :Budaya Organisasi dan Beban Kerja, Kinerja Pegawai
MANAJEMEN PENGELOLAAN USAHA ROTI DAN KUE ANEKA RASA SEBAGAI UPAYA PEMBERDAYAAN MASYARAKAT DI KECAMATAN KURANJI
Authors: Wati Linda , Rosha Zeshasina , Desiyanti Rika
Published: November 2021

Usaha Kecil dan Menengah (UKM) mempunyai peran yang strategis dalam pembangunan ekonomi nasional, selain berperan dalam pertumbuhan ekonomi dan penyerapan tenaga kerja juga berperan dalam pendistribusian hasil-hasil pembangunan. Sasaran Iptek Bagi Masyarakat (IbM) adalah usaha kecil yang berada di Kecamatan Kuranji Kota Padang. IbM memilih dua mitra usaha kecil yang bergerak di bidang makanan yaitu usaha kue dan roti. Hasil survei ketempat mitra terlihat bahwa mereka belum memberikan kemasan dan label yang menarik terhadap produk kue dan roti yang diproduksi, mengemas produk-produknya dengan bungkus ala kadarnya seperti menggunakan plastik bening dan diberi tambahan label dari kertas. Berdasarkan hasil wawancara terhadap kedua mitra terungkap bahwa kesulitan yang dihadapi oleh mitra ini adalah keterbatasan pemasaran karena produk belum dikenal, kendala dalam produksi karena masih kurangnya peralatan dan belum menggunakan sistem pembukuan.Dalam mengatasi masalah-masalah ini, tim mengusulkan bahwa makanan yang dijual mitra harus diberi kemasan dan label yang menarik. Dalam kemasan dicantumkan komposisi bahan dan label halal. Hal ini bertujuan untuk menambah kepercayaan konsumen. Untuk mempromosikan kue dan roti buatan mitra dilakukan dengan mempromosikan dari mulut ke mulut dengan cara membantu memasarkan ke koperasi dan kantin kampus Universitas Bung Hatta. Memberikan Pelatihan Terhadap Sistem Pembukuan. Mitra perlu dilatih membuat pembukuan, sehingga nantinya bisa memisahkan bagian modal yang digunakan untuk operasional usaha dan bagian uang yang dapat digunakan untuk keperluan sehari-hari. Metode pelatihan yang digunakan adalah memberikan pelatihan administrasi dan akuntansi dengan mengajarkan cara menghitung biaya produksi, rugi/laba dan membuat pembukuan untuk pengeluaran serta pendapatan.Penambahan modal dengan membelikan mixer kue dan mixer roti untuk memudahkan mitra melakukan proses pengocokan bahan baku utama. Mitra memiliki keterbatasan peralatan yaitu mixer yang digunakan masih mixer kecil, sehingga proses produksi menjadi lama.

Kata Kunci : Usaha kecil, Kemasan, Label, Sistem Pembukuan
PENGARUH SERVICE QUALITY TERHADAP LOYALITAS NASABAH DENGAN KEPUASAN NASABAH SEBAGAI VARIABEL INTERVENING
Authors: Mantauv Citra Suci
Published: November 2021

The aim of this study is to find out how the Service Quality affecting Customer Loyalty and find out also whether the Customer Satisfaction acts as an intervening variable. From the results of this study, the variable Service Quality (X) significantly affects on customer loyalty (Y) where the regression coefficient is 0.308 with a significant level 0.000. However, the value of the regression coefficient variable Service Quality (X) increases from 0.308 into 0.589. The variable of Customer Satisfaction (I) as an intervening variable significantly affect on customer loyalty (Y) with regression coefficient 0.261 and significance level is 0.000. The amount of influence on Customer Loyalty Service Quality (Y) was 0.556 (R 2 = 55.6). In other words, The increase of the influence of the variables on Customer Loyalty Service Quality (Y) in the presence of intervening variables (Customer Satisfaction) amounted to 16.5% or from 55.6% to 7:21%. So, it can be interpreted that the variable of Customer Satisfaction (I) mediates partially (partial mediation) the relationship between the variables of Service Quality (X) to Customer Loyalty (Y).

Keywords: Service Quality, Customer Loyalty, Customer Satisfaction
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN NASABAH PADA BANK NAGARI CABANG LUBUK SIKAPING
Authors: Yurasti Yurasti
Published: November 2021

THE IMPACT OF SERVICE QUALITY ON CUSTOMER SATISFACTION WITH BANK NAGARI BRANCH LUBUK SIKAPING

This study aims to determine how much the influence of the dimensions of service quality to the level of satisfaction felt by customers who use the services of Bank Nagari Lubuk Sikaping Branch. The model which is used in this study is the method of observation, interviews, questionnaires, and literature study by using a likert scale and sampling method used was accidental sampling a total of 100 samples. The analytical method used is multiple linear regression method (multiple linear regression). The results showed that the dimensions of service quality consists of Tangible (X1), Empathy (X2), Responsiveness (X3), Reliability (X4), and Assurance (X5) collectively - have the same positive effect. Where the regression equation Y = 10.671 + 0.688 X1 + 0.057 X2 + 0.318 X3 + 0.996 X4 - X5 + 0.209 + e. In addition, the F-test shows that the quality of services has a significant impact on customer satisfaction with a significant level of 0.000 or 0%. While based on partial test (t), all the variables also have a significant impact on customer satisfaction for Tangible significance level is 0.001, or 0.1%; Empathy is 0,001, or 0.1%; Responsiveness 0.001 or 0.1%; Reliability 0,000 or 0%; Assurance of 0.004 or 0.4%.

Keywords: Customer Satisfaction, Tangible, Empathy, Responsiveness, Reliability, and Assurance.
ANALISA PENGARUH BOPO TERHADAP PROFITABILITAS PT. BPR SWADAYA ANAK NAGARI SIMPANG EMPAT
Authors: Gustika Roza
Published: November 2021

Banking including BPR is very important to developing the economy. So, the bank must be have a level of optimal profitability continuously. This study to analized the effect of BOPO to Profitability of PT. BPR SAN. The data to be analized are the values of these variables in the quarterly report for the year 2010 - 2014. By the multiple linear regression analisys found that BOPO has a significant effect on NPM, but no significant effect on ROE and ROA. The implication of this research is PT. BPR SAN must improve the performance of credit porfolio in the ideal position and productive, but still have to consider the operational efficiency and the level of credit performance.

Keywords: profitability, ROA, ROE and BOPO
PENGARUH TUNTUTAN TUGAS TERHADAP KEPUASAN KERJA ANGGOTA DPRD KABUPATEN PASAMAN BARAT DENGAN STRES KERJA SEBAGAI VARIABEL INTERVENING
Authors: Yurasti Yurasti
Published: November 2021

This study aimed toseehowthe task demandsaffectjob satisfactionandseealso whetherwork stressrole asa variableintervening. Theresults ofthis study, thevariabletask demands (X) effect significantly 0,002. However, the value ofthe variabletask demandsregression coefficienthas decreasedfrom0.409into0.272. Work stress variable(I) as an intervening variablesignificant effect onjob satisfaction(Y) with regression coefficientis0.311andsignificantlevelof0,000. The amount effect ofwork stresson job satisfaction(Y) is0.443(R2 = 4.43). In other words,an increase invariableeffectof work stresson job satisfaction(Y) by 18%orfrom2.93%to 4.43%.It can beinterpretedthat thework stress variable(I) partiallymediatethe relationshipbetweentask demandsvariables(X) to job satisfaction(Y).

Keywords :Task Demands, Job Stress, Job satisfaction
PENGARUH HEDONIC SHOPPING VALUE, SHOPPING LIFESTYLE DAN POSITIVE EMOTION TERHADAP IMPULSE BUYING PADA PLAZA ANDALAS PADANG
Authors: Usvita Mega
Published: November 2021

This study was intended to see how the influence of Hedonic Shopping Value, Shopping Lifestyle and Positive Emotion against Impulse Buying on visitor of Plaza Andalas Padang . The population of this study is the consumers have ever shopped at Plaza Andalas Padang with a sample of 150. The technique of sampling using purposive sampling . Results of this study, the variables Hedonic Shopping Value ( X1 ) , Shopping Lifestyle ( X2 ) , and Positive Emotion ( X3 ) significantly affects to the Impulse Buying ( Y ) with a significant level of 0.000 . The influence of Hedonic Shopping Value ( X1 ) , Shopping Lifestyle ( X2 ) , and Positive Emotion ( X3 ) against Impulse Buying ( Y ) was 0.663 ( R2 = 66.3 ) .

Keywords :Hedonic Shopping Value, Shopping Lifestyle, Positive Emotion, Impulse Buying
PENGARUH KUALITAS PELAYANAN DAN NILAI PELANGGAN TERHADAP KEPUASAN MAHASISWA KULIAH PADA STIE PASAMAN
Authors: Lubis M Saleh
Published: November 2021

The Higher Educational Institution plays an important role to generate the high quality of Human Resources on Indonesia. Application of the professional marketing management on this institution is important too. Among the important aspects of marketing management is the words of mouth by the students were satisfied. This study examines the impact of service quality and customer value on satisfaction of students study at STIE Pasaman. Number of sampel is 241 people drawn by Slovin formula from 604 population. The results of this study showed the quality of service and customer value of each partial positive and significant impact on student satisfaction study at STIE Pasaman. The results of this study imply that in order to improve the satisfaction of students studying at STIE Pasaman can be done by increasing again service quality and customer value.

Key words : Satisfaction, service quality and customer value.
PENGARUH KOMPENSASI DAN KEPEMIMPINAN TERHADAP KINERJA DOSEN STIE PASAMAN SIMPANG EMPAT
Authors: Rosya Hendri
Published: November 2021

The Universities have an important role in producing the qualifed human resources. The universities must be implemented the human resource management included in improving the performance of lecturers. This study aimed to see how the effect of compensation and leadership in improving the performance of lecturers STIE Pasaman Simpang Empat. The results of this study indicate compensation and leadership of each partial positive and significant impact on the performance of lecturers. The implication of this research is that in order to improve the performance of lecturers can be done by increasing the compensation and leadership.

Keywords: Performance, compensation and leadership.
ANALISIS PENGARUH KINERJA KEUANGAN TERHADAP HARGA SAHAM PADA PERUSAHAAN PERBANKAN
Authors: Husna Nailal
Published: November 2021

The object of this study is a banking company whose shares are listed in Indonesia Stock Exchange 2011-2014 period, and the sampling method was census. The purpose of this study was to determine the effect of the financial performance of banking shares. And the research variables are Stock Price (Y), Return on Assets (X1), Debt to Equity Ratio (X2), Price Earning Ratio (X3), Earning Per Share (X4). Based on the analysis and discussion of the results of testing the hypothesis then the conclusion is Price Earning Ratio and Earning Per share, positive and significant impact on the share price, while Return on Assets, Dept To Equity Ratio, Earnings Per share no significant effect on stock price.

Keywords : Stock Price, Return on Assets, Debt To Equity ratio, Price Earning Ratio, Earnings Per Share, Bank
PENGARUH KOMPENSASI DAN KEPUASAN KERJA TERHADAP KINERJA PEGAWAI DINAS PERTANIAN TANAMAN PANGAN HOLTIKULTURA DAN PETERNAKAN KABUPATEN PASAMAN BARAT
Authors: Yurasti Yurasti
Published: November 2021

The purpose of this study was to determine the influence of Compensation and Job Satisfaction toward Employee Performance at the Department of Agriculture Horticulture and Animal Husbandry in West Pasaman. The population in this study were all contract employees in that place with sample size about 31 people, where sampling techniques using saturated sampling. The research instrument was a questionnaire. Thus, the data collection processed using multiple linear regression analysis with SPSS. From the result of this study found variable Compensation (X1) and Job Satisfaction (X2) on the Performance (Y) about 0,481 (R2 = 48.1).

Keywords : Compensation, Job Satisfaction, Performance
A Randomised, Crossover, Clinical Study to Assess Nicotine Pharmacokinetics and Subjective Effects of the BIDI® Stick ENDS Compared with Combustible Cigarettes and a Comparator ENDS in Adult Smokers
Authors: Fearon Ian , Gilligan Karin , Seltzer Ryan , McKinney Willie
Published: November 2021

INTRODUCTION: Nicotine pharmacokinetic (PK) assessments of electronic nicotine delivery systems (ENDS) are crucial to understand their ability to provide an alternative to cigarette smoking.  Subjective effects data also strongly contribute to this understanding.  The BIDI® Stick is a disposable ENDS product which contains 6% nicotine benzoate salt and various flavours.  METHODS: In this study we assessed nicotine PK and subjective effects of BIDI® Stick ENDS in adult smokers, compared to cigarettes and a comparator ENDS product.  During each of eight (8) study visits, volunteer smoker subjects randomly used one of either their usual brand (UB) of cigarette, a BIDI® Stick ENDS, or a comparator ENDS (JUUL 5% with Virginia Tobacco flavour), during both defined (10 puffs, 30 seconds apart) and _ad libitum _puffing sessions.  Blood samples were collected at various time points and subjective effects questionnaires were administered. RESULTS:  Plasma nicotine Cmax 0‑120 was not significantly different between BIDI® Stick ENDS with any flavour (range 15.3 (9.90) ng/ml for BIDI® Stick Winter to 17.6 (9.00) ng/ml for BIDI® Stick Classic) and UB cigarettes [16.2 (9.17) ng/ml].  AUC0-120 and Tmax 0‑120 values were also not significantly different between BIDI® Stick ENDS and UB cigarettes, while subjective effects measures were also similar between BIDI®Stick ENDS and UB cigarettes.  CONCLUSIONS: BIDI® Stick ENDS delivered nicotine to users comparably to their UB cigarette and also elicited similar subjective effects such as satisfaction and relief.  Thus, the BIDI®Stick ENDS may be a satisfying alternative to cigarettes among current smokers and may support their transitioning away from cigarette smoking.
LIPID PROFILE IN COPD PATIENTS
Authors: Bairwa Ramavatar , Pareek Pratibha
Published: November 2021

Background: The COPD patients are expected to have a deranged lipid profile for various reasons like smoking, aging, and using such drugs as steroids. Aims of study to estimate the lipid profile level in COPD patients.

Methods: This cross-sectional study was conducted on 50 COPD patients and including 50 control were enrolled in the study.

Results: The lipid profile in COPD patients, unpaired t test was performed and it was observed that COPD patients showed significantly higher serum levels of TC, TG, LDL and serum concentrations of HDL were also decreased significantly compared to controls.

Conclusion: COPD patients showed significantly higher serum cholesterol level in COPD patients as compared to controls.

Keywords: Total cholesterol, TG, COPD.
Inactivating Gene Expression with Antisense Modified Oligonucleotides
Authors: Altman Sidney , Angele-Martinez Carlos
Published: November 2021

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.
Peningkatan Motivasi dan Hasil Belajar Melalui Model Problem Based Learning
Authors: Ayudhityasari Rizky
Published: November 2021

Tujuan penelitian ini untuk meningkatkan motivasi dan hasil belajar Bahasa Indonesia kelas III Sekolah Dasar Negeri 2 Bolopleret. Penelitian ini merupakan penelitian tindakan kelas. Subjek penelitian adalah siswa sekolah dasar kelas III yang berjumlah 25 siswa. Pengumpulan data menggunakan teknik dokumentasi, observasi, angket dan tes. Validitas data menggunakan teknik triangulasi sumber dan triangulasi metode. Analisis data dilakukan secara deskriptif baik secara kualitatif maupun kuantitatif. Hasil penelitian sebagai berikut: (1) Motivasi belajar siswa yang berkategori “tinggi” yang awalnya pada siklus I sebesar 64% atau 16 siswa. Pada siklus II menjadi 92% atau 23 siswa.  2) Hasil belajar siswa sebelum tindakan hanya mencapai 32% atau 8 siswa yang tuntas. Setelah tindakan pada siklus I, sebanyak 11 siswa atau sebesar 44% belum mencapai ketuntasan belajar, 14 siswa atau sebesar 56% telah tuntas. Siklus II meningkat menjadi 4 siswa atau sebesar 16% belum tuntas, 21 siswa atau sebesar 84% telah tuntas. Sehingga dapat disimpulkan bahwa model problem bases learning dapat meningkatkan motivasi dan hasil belajar siswa.
Increased level of malondialdehyde in preterm labor
Authors: Sari Yesi Mustika , Yerizel Eti
Published: November 2021

Background: The pathophysiological mechanism associated with spontaneous preterm delivery is oxidative stress through the increased formation of reactive oxygen species (ROS) due to lipid peroxidation. Malondialdehyde (MDA) is one of the biomarkers of oxidative stress produced through the lipid peroxidation process.

Objective: The aim of this study is to observe the difference in MDA levels among preterm labor compared to full-term labor.

Methods: Observational research was conducted with a comparative cross-sectional design. Maternal venous blood samples were taken from private hospitals and midwives in Padang city and Aro Suka Hospital Solok Regency. Samples were selected by consecutive sampling and divided into two groups with a total of 40 samples. MDA level was measured using the spectrophotometry method.

Results: MDA levels in preterm delivery were 3,6±0.42 nmol/mL and in full-term delivery were 2.9±0.33 nmol/mL.

Conclusion: There was a significant difference in MDA levels between preterm labor and full-term delivery. MDA levels in preterm childbirth were higher than MDA levels in full-term delivery.
Making the Case for Your Immigrant Future
Authors: Integration Canada Excellence Research Chair in Migration &
Published: November 2021

Today's Presentation:

Our Demographic Challenge

How Immigrants Boost the Economy

About the Immigrant Futures Project & Framework

Initiating a Whole of Community Approach

Community Stakeholders & Assets