MATERNAL DYSLIPIDEMIA AND OBESITY/GESTATIONAL DIABETES MELLITUS ARE ASSOCIATED AN UPCOMING INVESTIGATION
Authors: Saima Aziz Siddiqui  , Farah Shabih Ul Hasnain  , Afshan Hasan  , Aneela Habib Riffat  , Jaleel  
Published: June 2024

Background: Maternal dyslipidemia and gestational diabetes are known to be associated, however it is unknownhow obesity plays a role in this interaction. We examined the relationship between fasting lipids at the oral glucosetolerance test (OGTT) in women diagnosed with GDM and maternal obesity at the first prenatal visit.Objectives: The study aims to investigate the relationship between maternal dyslipidemia and gestational diabetesmellitus (GDM), pinpoint risk factors, elucidate procedures, and provide guidance for therapeutic treatments aimedat improving the health of expectant mothers.Study design: A prospective studyDuration and place of study: from jan 2022 to jan 2023 at Dow University Karachi, PakistanMethods: This prospective study was undertaken at Dow University Karachi, which has an annual delivery rateexceeding 150 pupils. At their first prenatal hospital visit, participants who were between the ages of 20 and 45 andhad at least one maternal risk factor for GDM were enlisted. Pregnant women with diabetes mellitus or those whohave had several pregnancies were excluded. To investigate maternal risk factors and GDM outcomes, laboratorytests were carried out, interviews were done, and medical records were examined. In the statistical analysis, logisticregression and descriptive statistics were used to find relationships between risk factors and the development of GDM.The purpose of this study at Dow University Karachi was to ascertain the impact of risk factors on the incidence ofGDM in young women.Results: The features of the research population were classified according to the presence or absence of GDM. 150women consented to participate in the research during their first prenatal visit. The study’s findings demonstrated astrong correlation between maternal traits and the prevalence of gestational diabetes mellitus (GDM). An average oflate adolescence and a younger mother age indicated a greater risk of GDM. It was noted that maternal obesity wasprevalent among individuals who had GDM and that it posed a significant risk. GDM risk was linked to specificrisk factors like a family history of diabetes mellitus, a prior diagnosis of GDM, and a high body mass index.Additionally, elevated fasting cholesterol, particularly triglycerides, and total cholesterol were particularly high in theGDM group, highlighting the importance of maternal cholesterol. These results emphasise the complexity of GDMdevelopment and the need of focused preventive measures.Conclusion: The study looked at the link between maternal dyslipidemia and gestational diabetes mellitus (GDM),emphasizing the impact obesity plays in this interaction. Although the study’s goals and methods are explained inthe abstract, the findings are regrettably not shared. However, the study has the potential to further our knowledgeof the intricate interactions among maternal Obesity, dyslipidemia, and GDM. These results may have significantramifications for identifying pregnant women who are at risk and creating focused treatments to enhance the health ofpregnant moms and their unborn children. The study’s benefits to maternal healthcare must be fully appreciated bymore Study and a comprehensive presentation of the findings.Keywords: maternal dyslipidemia, gestational diabetes mellitus (GDM), and pregnancy complications