bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoting an Entrepreneurial Culture: Development, Feasibility and Acceptability of a Primary School-Based Program Focused on Soft Skills
Authors: Jardim Jacinto , Pereira Anabela , Bartolo Ana , Pinho Andreia , Cardoso Monica , Catanho Paixão
Published: October 2023

This study aims to develop and evaluate the feasibility and acceptability of an intervention program designed to foster soft skills among primary-school students. Conducted in Portugal, the program employed face-to-face sessions and involved 2958 fourth-grade students from nine municipalities. The program “Players of Dreams” (PD) [“Brincadores de Sonhos”] is an active learning approach that encourages students and other educational community members to engage actively in the learning process. The PD content was derived from a literature review and interviews with primary school teachers regarding the essential skills for success in life, like the considerable skills of an entrepreneurial culture. The PD program utilized group dynamics, pedagogical narratives/storytelling, visual thinking strategies (diagrams and illustrations), family involvement in activities, and specially prepared songs to facilitate learning. Teachers who implemented the program underwent 25 h of classroom training on entrepreneurial pedagogy and received a manual for conducting PD sessions. Students completed activities in their PD manuals and corresponding evaluation forms throughout the program The results provide preliminary evidence to support the benefits of implementing the intervention. The facilitators observed changes in student behavior related to the promotion of confidence, responsibility, sociability, and autonomy. The PD program shows promise for engaging young students and fostering the growth of an entrepreneurial culture. Future research could assess the effectiveness of PD in delivering education and support interventions, while longitudinal studies could provide valuable quantitative and qualitative data to inform educational policies for primary schools.
Distributed Platform for Offline and Online EV Charging Simulation
Authors: Perez Joaquim , Quintal Filipe , Pereira Lucas
Published: October 2023

Efforts to enhance electric vehicle (EV) charging processes have spurred the emergence of smart charging algorithms. However, these studies are intricate and costly, necessitating preliminary simulations to assess EV integration into power grids. Existing solutions to this issue tend to be limited to academia and proprietary systems. To address this, we propose a user-friendly and intuitive simulation tool employing a decoupled and flexible architecture. This architecture, achieved through open design and containerized microservices, streamlines maintenance, extension, and scalability. We substantiated the validity of our solution by simulating the charging infrastructure from an H2020 Research Project. Furthermore, we integrated our solution with an external system that executes smart charging algorithms. The proposed system yielded the desired results, enabling the project team to evaluate both the integration and algorithms, even amidst the COVID-19 lockdown.
Robust Position Control for an Electrical Automatic Transmission under Gear-Shifting Link Friction
Authors: Kim Junghyun , Choi Jung Hyun
Published: October 2023

The automotive industry is evolving, with software becoming a vital part of vehicles. Conventional automakers are shifting to software-centric entities, embracing over-the-air (OTA) updates and service-centric models. To move software-driven vehicles, the vehicle must also be electrified. Several automobile manufacturers are electrifying vehicle parts, and recently, a gear shift selector for automatic transmissions was adapted from mechanical to electronic. However, as conventional mechanical systems are modified to electrical systems, problems such as shift delay and accuracy emerge. This study addresses these problems that emerge in the electronic system type of automatic transmission, including a gear shift selector developed to electrify automobiles. Accordingly, we first analyze the structure of automatic transmission systems, then define the operation sequence. Next, a novel position control algorithm based on a disturbance observer is proposed to reduce shift delay and increase accuracy. The proposed algorithm operates harmoniously with the vehicle control unit (VCU). To verify the proposed algorithm, a hardware-in-the-loop simulation (HILS) was developed to experiment with vehicle shifting using a commercial electronic gear shift selector. Moreover, the proposed control algorithm for gear shifting in an automatic transmission was analyzed using experimental results obtained by assuming a specific driving situation in the HILS.
Effect of Bioactive Compounds from Pumpkin Powder on the Quality and Textural Properties of Shortbread Cookies
Authors: Ghendov-Mosanu Aliona , Netreba Natalia , Balan Greta , Cojocari Daniela , Boestean Olga , Bulgaru Viorica , Gurev Angela , Popescu Liliana , Deseatnicova Olga , Resitca Vladislav , Socaciu Carmen , Pintea Adela , Sanikidze Tamar , Sturza Rodica
Published: October 2023

The problem of food with functional ingredients, characterized by low energy intake and a variety of phytonutrients with biological activity, is one of the concerns of the population. The objectives of this study were to investigate the effect of pumpkin powder and its bioactive components on the quality, color and textural properties of shortbread cookies. In the drying process of pumpkin powder (Cucurbita moschata) at 60 ± 2 °C, the physicochemical parameters did not change significantly in relation to fresh pulp. The chromatic parameters L*, a* and b* showed that the pumpkin powder was brighter than the pulp, with a greater presence of yellow pigments. Pumpkin powder presented a rich source of bioactive compounds (polyphenols flavonoids, carotenoids) with an antioxidant potential of 161.52 mmol TE/100 g DW and 558.71 mg GAE/100 g DW. Antimicrobial activity against Gram-positive (Staphylococcus aureus, Bacillus cereus), Gram-negative (Escherichia coli, Salmonella Abony and Pseudomonas aeruginosa) bacteria and high antifungal activity against Candida albicans were attested. The sensory, physicochemical, texture parameters and color indicators of shortbread cookies with yellow pumpkin powder (YPP) added in a proportion of 5–20% were analyzed. The optimal score was given to the sample of 15% YPP. The use of 15–20% YPP contributed to improved consistency due to the formation of complexes between starch and protein.
Who Wants to Be a Geomorphologist? Gamification in a BSc Teaching Course
Authors: Segoni Samuele
Published: October 2023

Despite the importance of Earth sciences in addressing the global challenges that humanity is presently facing, attention toward related disciplines has been witnessed to be globally declining at various levels, including education and university teaching. To increase students’ engagement and explore alternative teaching activities, a didactical experiment was carried out at the University of Florence (Italy); the teaching course, “basic elements of geomorphology”, was reorganized to include relevant elements of gamification. Parallel to the frontal lessons, a competition based on a recurring quiz game was conducted. This activity was called “Who wants to be a Geomorphologist?”, clearly paraphrasing a notorious TV show. During every lesson, a moment was included where the students used their mobile devices to access a series of quizzes that were previously prepared by the teacher to test the reasoning skills of the students and their abilities to make connections between distinct topics. A commercial educational app was used to organize the activity, run the quiz sessions, assign points, and update the leaderboard in real time. A quantitative evaluation procedure assessed the positive impacts in terms of supporting the learning process, improving the engagement in the teaching course, and fostering the liking for geomorphology.
Provenance of the Papuan Peninsula (Papua New Guinea): Zircon Inheritance from Miocene–Pliocene Volcanics and Volcaniclastics
Authors: Holm Robert J. , Heilbronn Kelly , Saroa Dulcie , Maim Gideon
Published: October 2023

Plate tectonic reconstructions of Papua New Guinea prior to the late Cenozoic are characterized by a lack of provenance data to constrain the relative origin of the allochthonous terranes. At present, plate tectonic reconstructions of this region infer that the accreted New Guinea terranes at the northern Australian continental margin are likely autochthonous or para-autochthonous in nature. This study presents the results of an investigation into zircons derived from Miocene–Pliocene volcanics and volcaniclastics of the Papuan Peninsula. Results from U-Pb zircon geochronology inform the recent geological history of the Papuan Peninsula, with magmatism active in the late Miocene and early Pliocene, between approximately 9 Ma and 4.5 Ma. More significantly, however, is the recognition of extensive inherited zircon grains within the volcanic and volcaniclastic sequences. These inherited zircon grains are most likely sourced from the Owen Stanley Metamorphics, which form the basement rocks of the Papuan Peninsula. Provenance of the inherited zircon grains imply that the Cretaceous volcaniclastic protolith of the Owen Stanley Metamorphics must have had input from continental detritus, but this cannot be derived from North Queensland, Australia as inferred by current reconstructions. Instead, zircon U-Pb age spectra correlate with probable source regions further to the south, adjacent to the Shoalwater Formation of the Central Queensland margin, and New Caledonia. These findings suggest that late Mesozoic and Cenozoic regional reconstructions of eastern Australia and the Southwest Pacific require major revision and that additional work is undertaken to inform the provenance of such allochthonous terranes.
Influence of Root Reinforcement on Shallow Landslide Distribution: A Case Study in Garfagnana (Northern Tuscany, Italy)
Authors: Marzini Lorenzo , D’Addario Enrico , Papasidero Michele Pio , Chianucci Francesco , Disperati Leonardo
Published: October 2023

In this work, we evaluated the influence of root structure on shallow landslide distribution. Root density measurements were acquired in the field and the corresponding root cohesion was estimated. Data were acquired from 150 hillslope deposit trenches dug in areas either devoid or affected by shallow landslides within the Garfagnana Valley (northern Tuscany, Italy). Results highlighted a correlation between the root reinforcement and the location of measurement sites. Namely, lower root density was detected within shallow landslides, with respect to neighboring areas. Root area ratio (RAR) data allowed us to estimate root cohesion by the application of the revised version of the Wu and Waldron Model. Then, we propose a new method for the assimilation of the lateral root reinforcement into the infinite slope model and the limit equilibrium approach by introducing the equivalent root cohesion parameter. The results fall within the range of root cohesion values adopted in most of the physically based shallow landslide susceptibility models known in the literature (mean values ranging between ca. 2 and 3 kPa). Moreover, the results are in line with the scientific literature that has demonstrated the link between root mechanical properties, spatial variability of root reinforcement, and shallow landslide locations.
Durable Continuous-Flow Mechanical Circulatory Support
Authors: Pepper John
Published: October 2023

The prevalence of heart failure in the UK is 1 in 35 people aged from 65 to 74 and 1 in 15 people aged from 75 to 84 [...]
Comparative Analysis of Machine-Learning Models for Recognizing Lane-Change Intention Using Vehicle Trajectory Data
Authors: Yuan Renteng , Ding Shengxuan , Wang Chenzhu
Published: October 2023

Accurate detection and prediction of the lane-change (LC) processes can help autonomous vehicles better understand their surrounding environment, recognize potential safety hazards, and improve traffic safety. This study focuses on the LC process, using vehicle trajectory data to select a model for identifying vehicle LC intentions. Considering longitudinal and lateral dimensions, the information extracted from vehicle trajectory data includes the interactive effects among target and adjacent vehicles (54 indicators) as input parameters. The LC intention of the target vehicle serves as the output metric. This study compares three widely recognized machine-learning models: support vector machines (SVM), ensemble methods (EM), and long short-term memory (LSTM) networks. The ten-fold cross-validated method was used for model training and evaluation. Classification accuracy and training complexity were used as critical metrics for evaluating model performance. A total of 1023 vehicle trajectories were extracted from the CitySim dataset. The results indicate that, with an input length of 150 frames, the XGBoost and LightGBM models achieve an impressive overall classification performance of 98.4% and 98.3%, respectively. Compared to the LSTM and SVM models, the results show that the two ensemble models reduce the impact of Types I and III errors, with an improved accuracy of approximately 3.0%. Without sacrificing recognition accuracy, the LightGBM model exhibits a sixfold improvement in training efficiency compared to the XGBoost model.
The Role of Extracorporeal Membrane Oxygenation ECMO in Accidental Hypothermia and Rewarming in Out-of-Hospital Cardiac Arrest Patients—A Literature Review
Authors: Hymczak Hubert , Gołąb Aleksandra , Kosiński Sylweriusz , Podsiadło Paweł , Sobczyk Dorota , Drwiła Rafał , Kapelak Bogusław , Darocha Tomasz , Plicner Dariusz
Published: October 2023

Accidental hypothermia, defined as an unintentional drop of the body core temperature below 35 °C, is one of the causes of cardiocirculatory instability and reversible cardiac arrest. Currently, extracorporeal life support (ECLS) rewarming is recommended as a first-line treatment for hypothermic cardiac arrest patients. The aim of the ECLS rewarming is not only rapid normalization of core temperature but also maintenance of adequate organ perfusion. Veno-arterial extracorporeal membrane oxygenation (ECMO) is a preferred technique due to its lower anticoagulation requirements and potential to prolong circulatory support. Although highly efficient, ECMO is acknowledged as an invasive treatment option, requiring experienced medical personnel and is associated with the risk of serious complications. In this review, we aimed to discuss the clinical aspects of ECMO management in severely hypothermic cardiac arrest patients.
Skeletal Muscle Quality and Quantity Affect Prognosis after Neoadjuvant Chemotherapy with a Triple Regimen of Docetaxel/Cisplatin/5-FU in Patients with Esophageal Cancer
Authors: Ito Nobuhito , Tajika Masahiro , Tanaka Tsutomu , Yamada Keisaku , Takagi Akihiro , Onishi Sachiyo , Abe Tetsuya , Higaki Eiji , Fujieda Hironori , Inaba Yoshitaka , Muro Kei , Kawashima Hiroki , Niwa Yasumasa
Published: October 2023

The purpose of this study was to identify factors associated with the prognosis after docetaxel, cisplatin, and 5-fluorouracil (DCF) neoadjuvant chemotherapy (NAC) in patients with advanced esophageal squamous cell carcinoma (ESCC) undergoing surgical resection. We retrospectively examined a total of 100 patients who received neoadjuvant DCF therapy for ESCC at our institution between 2011 and 2020. The psoas muscle index (PMI) was calculated from the psoas muscle area at the L3 vertebral level, and the intramuscular adipose tissue content (IMAC) was calculated from the mean CT value of the multifidus muscle and from four points of subcutaneous fat. The median PMI value was 6.11 cm2/m2 (range, 3.12–11.07 cm2/m2) in men and 3.65 cm2/m2 (range, 2.70–6.82 cm2/m2) in women. The median IMAC was −0.426 (range, −0.079–−0.968) in men and −0.359 (range, −0.079–−0.671) in women. Based on the PMI, IMAC, and other patient factors, factors associated with NAC-DCF postoperative survival were identified using multivariate Cox regression analysis. A high IMAC was significantly related to overall survival after surgery (p = 0.005, hazard ratio 2.699). A comparison of Kaplan–Meier curves showed that the 5-year survival rate was 76.5% in the low IMAC group and 42.7% in the high IMAC group (log-rank test; p = 0.001). A low IMAC was associated with good survival outcomes and was an independent prognostic factor in patients with cStage II/III ESCC who were treated with the NAC-DCF regimen and underwent surgical resection.
Medical Rehabilitation of Patients with Post-COVID-19 Syndrome—A Comparison of Aerobic Interval and Continuous Training
Authors: Mooren Johanna M. , Garbsch René , Schäfer Hendrik , Kotewitsch Mona , Waranski Melina , Teschler Marc , Schmitz Boris , Mooren Frank C.
Published: October 2023

Introduction: Post-COVID-19 syndrome (PCS) is a multisystemic disorder marked by impaired physical performance as one lead symptom. Since it has been suggested that endurance training as part of medical rehabilitation may be effective in improving physical performance capacity in PCS, this study aimed to compare different modes of aerobic endurance training. Methods: A total of 110 PCS patients (49.3 ± 11.8 years; 38% women; time after infection = 260.2 ± 127.5 days) underwent detailed clinical screening including symptom-limited cardiopulmonary exercise testing at admission and after 4–6 weeks of inpatient medical rehabilitation. Questionnaires were used to assess disease perception. Patients performed controlled isocaloric cycle ergometer training (3–5 sessions/week; 18 min) as either continuous training (CT) at 50% of maximal workload or as interval training (IT; load = 60%, relief = 30%). Outcomes of PCS patients were compared to coronary artery disease patients (CAD; n = 96) to evaluate overall training effectiveness. Results: Training participation was comparable between the groups, with no indication of training-specific exercise-induced fatigue. Overall, PCS patients improved significantly by a mean of 6.8 ± 12.1% for W at VT1; 3.1 ± 10.0% for VO2 at VT1; 5.5 ± 14.7% for O2 pulse at VT1; 7.5 ± 15.0% for W at VO2peak; 2.7 ± 11.0% for VO2peak and 4.6 ± 12.4% for O2 pulse at VO2peak (all p < 0.05) with no significant differences between groups (p > 0.05). Both groups showed reduced levels of fatigue, anxiety, and depression as well as improved quality of life and wellbeing (all p < 0.05). Compared to guideline-based cardiac rehabilitation, PCS patients showed a similar improvement in workload and oxygen uptake compared to CAD patients. Conclusion: PCS patients benefit from aerobic endurance training performed as moderate continuous or interval training as part of a medical rehabilitation program in terms of improved physical exercise capacity and disease perception. The results for PCS patients are comparable to the guideline-based rehabilitation of CAD patients.
Bleb Morphology on Anterior-Segment Optical Coherence Tomography after XEN Gel Stent Implantation
Authors: Wy Seoyoung , Shin Young In , Kim Young Kook , Jeoung Jin Wook , Park Ki Ho
Published: October 2023

We investigated the internal morphology of filtration blebs after XEN gel stent implantation using anterior segment optical coherence tomography (AS-OCT) and identified factors related to intraocular pressure (IOP) postoperatively. Eighteen eyes of 18 patients who had undergone XEN gel stent implantation were analyzed. Blebs were imaged using Visante OCT (Carl Zeiss Meditec AG, Germany) at 6 months and 1 year after surgery and evaluated for quantitative parameters including bleb height, maximum height of internal cavity, maximum bleb wall thickness, and maximum bleb epithelial thickness. Subjects were classified into two groups according to the presence or absence of a definite internal cavity between the conjunctiva and sclera using AS-OCT imaging. Nine eyes (50%) were assigned to the internal cavity group and 9 (50%) to the uniform group. Postoperative IOP was significantly lower in the internal cavity group than in the uniform group both at 6 months and 1 year after surgery (p = 0.024 and p = 0.040). Postoperative IOP showed statistically significant negative correlations with bleb height and the height of the internal cavity (Spearman correlation coefficient r = −0.518, p = 0.028 and r = −0.453, p = 0.034, respectively). AS-OCT facilitates analysis of bleb morphology after XEN gel stent implantation. A larger height of the internal cavity of the bleb appeared to correlate with lower IOP after XEN implantation.
The Role of Pharmacogenetics in the Therapeutic Response to Thiopurines in the Treatment of Inflammatory Bowel Disease: A Systematic Review
Authors: Ribeiro Aline C. , Gerheim Pâmela S. A. S. , Chebli Julio Maria Fonseca , Nascimento Jorge Willian L. , de Faria Pinto Priscila
Published: October 2023

This study focuses on the use of thiopurines for treating inflammatory bowel diseases (IBD). These drugs undergo enzymatic changes within the body, resulting in active and inactive metabolites that influence their therapeutic effects. The research examines the role of genetic polymorphisms in the enzyme thiopurine S-methyltransferase (TPMT) in predicting the therapeutic response and adverse effects of thiopurine treatment. The TPMT genotype variations impact the individual responses to thiopurines. Patients with reduced TPMT activity are more susceptible to adverse reactions (AEs), such leukopenia, hepatotoxicity, pancreatitis, and nausea, which are common adverse effects of thiopurine therapy. The therapeutic monitoring of the metabolites 6-thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine (6-MMP) is proposed to optimize treatment and minimize AEs. Patients with higher 6-TGN levels tend to have better clinical responses, while elevated 6-MMP levels are linked to hepatotoxicity. Genotyping for TPMT before or during treatment initiation is suggested to tailor dosing strategies and enhance treatment efficacy while reducing the risk of myelosuppression. In conclusion, this study highlights the importance of considering genetic variations and metabolite levels in optimizing thiopurine therapy for IBD patients, focusing on balance therapeutic efficacy with the prevention of adverse effects and contributing to personalized treatment and better patient outcomes.
Medium-Term Clinical Outcomes of the Global Icon Stemless Shoulder System: Results of a 2-Year Follow-Up
Authors: Zbeda Robert , Asaid Raf , Warby Sarah A. , Cassidy John Tristan , Hoy Gregory
Published: October 2023

The primary aim of this study was to assess the medium-term outcomes of the Global Icon stemless shoulder replacement in patients who have undergone primary total shoulder arthroplasty (TSA) for glenohumeral joint osteoarthritis. A retrospective review of patients who had undergone a TSA using the Global Icon stemless shoulder system was performed. The Western Ontario Osteoarthritis Shoulder (WOOS) Index and Oxford Shoulder Score (OSS) were evaluated pre-operatively and at 12 to 24 months post-operatively. Radiological outcomes, operation time, and post-operative complications were reported. Primary analysis for the WOOS Index and OSS focused on detecting within-group treatment effects at 24 months using a repeated measures ANOVA. Thirty patients were included in the study. Post-surgery, there was a significant improvement at 24 months on the OSS (ES = 0.932, CI: 41.7 to 47.7, p < 0.001) and the WOOS Index (ES = 0.906, CI: 71.9 to 99.8, p < 0.001). Radiographs revealed that no component loosened, migrated, or subsided. The median operative time was 75.5 (IQR: 12.25, range: 18 to 105) min. No implant-related complications were reported. The Global Icon stemless replacements have excellent clinical outcomes in this cohort at 12- and 24-month follow-up with no implant-related complications.
Land Use and Land Cover Changes in Depopulated Areas of Mediterranean Europe: A Case Study in Two Inland Provinces of Spain
Authors: Gallardo Marta , Fernández-Portela Julio , Cocero David , Vilar Lara
Published: October 2023

Depopulation often leads to the abandonment of agricultural land and the resulting process of afforestation and reforestation. In this paper, we study the land use changes between 2000 and 2018 in two Spanish provinces, Soria and Teruel. The provinces chosen as case studies are of particular interest because they have some of the lowest population densities in Europe and continue to suffer depopulation processes that have been ongoing since the mid-20th century. The reasons for this are not immediately clear given that unlike other European regions with similar population density values, for example in Northern Scandinavia, they are not exposed to extreme climatic conditions, nor are they located in isolated mountain regions. Using the CORINE Land Cover database, we observed that in both provinces, there has been an expansion in shrub and forest land uses and a decline in agriculture due largely to the fact that certain areas have been abandoned by their inhabitants, although in other parts of these provinces, the amount of land used for agriculture has increased. Urban growth over this period has been minimal. In the coming years, it seems likely that the population of these areas will continue to fall, given that the policies carried out over decades to try to revert this trend have not been successful.
Complete Mitochondrial Genome Assembly of an Upland Wild Rice Species, Oryza granulata and Comparative Mitochondrial Genomic Analyses of the Genus Oryza
Authors: Zhang Fen , Kang Haiqi , Gao Lizhi
Published: October 2023

Wild upland rice species, including Oryza granulata, possess unique characteristics that distinguish them from other Oryza species. For instance, O. granulata characteristically has a GG genome and is accordingly classified as a basal lineage of the genus Oryza. Here, we deployed a versatile hybrid approach by integrating Illumina and PacBio sequencing data to generate a high-quality mitochondrial genome (mitogenome) assembly for O. granulata. The mitogenome of O. granulata was 509,311 base pairs (bp) with sixty-seven genes comprising two circular chromosomes, five ribosomal RNA (rRNA) coding genes, twenty-five transfer RNA (tRNA) coding genes, and thirty-seven genes coding for proteins. We identified a total of 378 simple sequence repeats (SSRs). The genome also contained 643 pairs of dispersed repeats comprising 340 palindromic and 303 forward. In the O. granulata mitogenome, the length of 57 homologous fragments in the chloroplast genome occupied 5.96% of the mitogenome length. Collinearity analysis of three Oryza mitogenomes revealed high structural variability and frequent rearrangements. Phylogenetic analysis showed that, compared to other related genera, O. granulata had the closest genetic relationship with mitogenomes reported for all members of Oryza, and occupies a position at the base of the Oryza phylogeny. Comparative analysis of complete mitochondrial genome assemblies for Oryza species revealed high levels of mitogenomic diversity, providing a foundation for future conservation and utilization of wild rice biodiversity.
Construction of a Banker Plant System via the Host Switch Trait of a Natural Enemy Aenasius bambawalei
Authors: Zhang Juan , Huang Jun , Tang Yayuan , Lu Yaobin , Zhou Zhongshi
Published: October 2023

Understanding the most effective host switch patterns in parasitic wasps, specifically Aenasius bambawalei (AB), is crucial for effectively controlling pests like Penacoccus solenopsis (PSS). This study aims to elucidate AB’s ideal host switch pattern and assess its utility in maintaining synchronization between AB and PSS, thereby aiding in PSS control. We examined various host switch patterns and cycles to evaluate their impact on AB’s offspring’s parasitism rates and fitness in laboratory conditions. Concurrently, we assessed the fitness of both PSS and AB on tomato plants using different banker plant systems to maintain field synchronization. Results indicate that the three-repeat T1 host switch pattern of PSS-Penacoccus solani (PSI)-PSS was the most effective. Additionally, a specific banker plant system, “System B”, which provided succulent plants hosting PSI, was optimal for synchronizing AB and PSS in a summer greenhouse setting. Our findings underscore the importance of employing specific host switch patterns and banker plant systems to effectively control PSS in the field. This research offers foundational data for incorporating a banker plant system into integrated pest management strategies for enhanced PSS control.
Multivariate SVR Demand Forecasting for Beauty Products Based on Online Reviews
Authors: Wang Yanliang , Zhang Yanzhuo
Published: October 2023

Owing to changes in consumer attitudes, the beauty consumer population is growing rapidly and the demands of beauty consumers are variable. With a wide range of beauty products and exaggerated product promotions, consumers rely more on online reviews to perceive product information. In this paper, we propose a demand forecasting model that takes into account both product features and product emotional needs based on online reviews to help companies better develop production and sales plans. Firstly, a Word2vec model and sentiment analysis method based on a sentiment dictionary are used to extract product features and factors influencing product sentiment; secondly, a multivariate Support Vector Regression (SVR) demand prediction model is constructed and the model parameters are optimized using particle swarm optimization; and finally, an example analysis is conducted with beauty product Z. The results show that compared with the univariate SVR model and the multivariate SVR model with only product feature demand as the influencing factor, the multivariate SVR model with both product feature and product sentiment demand as influencing factors has a smaller prediction error, which can enable beauty retail enterprises to better grasp consumer demand dynamics, make flexible production and sales plans, and effectively reduce production costs.
Advances in Computational Approaches for Estimating Passive Permeability in Drug Discovery
Authors: Bernardi Austen , Bennett W. F. Drew , He Stewart , Jones Derek , Kirshner Dan , Bennion Brian J. , Carpenter Timothy S.
Published: October 2023

Passive permeation of cellular membranes is a key feature of many therapeutics. The relevance of passive permeability spans all biological systems as they all employ biomembranes for compartmentalization. A variety of computational techniques are currently utilized and under active development to facilitate the characterization of passive permeability. These methods include lipophilicity relations, molecular dynamics simulations, and machine learning, which vary in accuracy, complexity, and computational cost. This review briefly introduces the underlying theories, such as the prominent inhomogeneous solubility diffusion model, and covers a number of recent applications. Various machine-learning applications, which have demonstrated good potential for high-volume, data-driven permeability predictions, are also discussed. Due to the confluence of novel computational methods and next-generation exascale computers, we anticipate an exciting future for computationally driven permeability predictions.
A Mechanistic Model for Hydrogen Production in an AnMBR Treating High Strength Wastewater
Authors: Vera Gino , Feijoo Felipe A. , Prieto Ana L.
Published: October 2023

In the global race to produce green hydrogen, wastewater-to-H2 is a sustainable alternative that remains unexploited. Efficient technologies for wastewater-to-H2 are still in their developmental stages, and urgent process intensification is required. In our study, a mechanistic model was developed to characterize hydrogen production in an AnMBR treating high-strength wastewater (COD > 1000 mg/L). Two aspects differentiate our model from existing literature: First, the model input is a multi-substrate wastewater that includes fractions of proteins, carbohydrates, and lipids. Second, the model integrates the ADM1 model with physical/biochemical processes that affect membrane performance (e.g., membrane fouling). The model includes mass balances of 27 variables in a transient state, where metabolites, extracellular polymeric substances, soluble microbial products, and surface membrane density were included. Model results showed the hydrogen production rate was higher when treating amino acids and sugar-rich influents, which is strongly related to higher EPS generation during the digestion of these metabolites. The highest H2 production rate for amino acid-rich influents was 6.1 LH2/L-d; for sugar-rich influents was 5.9 LH2/L-d; and for lipid-rich influents was 0.7 LH2/L-d. Modeled membrane fouling and backwashing cycles showed extreme behaviors for amino- and fatty-acid-rich substrates. Our model helps to identify operational constraints for H2 production in AnMBRs, providing a valuable tool for the design of fermentative/anaerobic MBR systems toward energy recovery.
Evaluation of Organic and Inorganic Foulant Interaction Using Modified Fouling Models in Constant Flux Dead-End Operation with Microfiltration Membranes
Authors: Qasim Muhammad , Akbar Ali , Khan Imtiaz Afzal , Ali Mumtaz , Lee Eui-Jong , Lee Kang Hoon
Published: October 2023

The goal of this study was to elucidate the interaction of complex feed solutions under modified membrane fouling models for constant flux operation. The polyvinylidene fluoride membrane (PVDF) was tested for three types of solutions containing inorganic foulants (Al, Mn, and Fe), organic foulants, and suspended solids at 0.5 mM Ca2+ ionic strength. The membrane’s performance was evaluated by measuring the increase in transmembrane pressure (TMP) during two different filtration scenarios: continuous filtration lasting 1 h and cyclic filtration lasting 12 min, with 3 min backwashing cycles included. Statistical analysis (linear regression results (R2), p-value) was used to verify the fouling model propagation along with the determination of the contributing constant of each fouling model. An increasing TMP percentage of 164–302%, 155–300%, and 208–378% for S1 (HA + Ca2+), S2 (inorganics + kaolin + Ca2+), and S3 (HA + inorganics + kaolin + Ca2+) was recorded for 1 h filtration, respectively. Furthermore, a five percent increase in irreversible resistance was noted for the S3 solution due to the strong adsorption potential of foulants for the PVDF membrane caused by the electrostatic and hydration forces of foulants. In addition to that, the participation equation elucidated the contribution of the fouling model and confirmed that complete blocking and cake layer contribution were dominant for the S1 and S3 solutions, while standard blocking was dominant for the S2 solution with a high significance ratio. Moreover, R2 and cyclic filtration analysis also confirmed the propagation of these fouling models. The statistical confirmation and regression results analysis of the modified model gave comparative results and satisfied the filtration mechanism and can be used for the constant flux dead filtration analysis of water treatment.
Small Punch Test on Jominy Bars for High-Throughput Characterization of Quenched and Tempered Steel
Authors: Miguel Ibon , Berriozabalgoitia Itziar , Artola Garikoitz , Macareno Luis María , Angulo Carlos
Published: October 2023

Studying the effect of quench and tempering heat treatments on steel, more specifically screening the effect of the austenitizing, quenching, and tempering conditions on mechanical properties, can be extremely material- and time-consuming when standard tensile testing specimens are employed. Jominy bar end quench testing has been used as a standard method to reduce the resources that are required for this type of screening. Jominy bar testing by itself shows, though, the limitation of yielding only hardness and microstructure as a result. In the last few years, the small punch test (SPT) standard has been developed. This technique can obtain an estimation of tensile mechanical properties with miniaturized specimens, which can be dissected from Jominy bars. The paper proposes a new testing methodology for screening the outcome of heat treatment conditions by combining the Jominy bar testing and SPT. Quench and tempering of API 5L X65Q pipe steel is used as a case study to describe the proposed methodology. The ability of the Jominy with SPT to detect variations in the mechanical properties produced by heat treatments is shown. This methodology can be directly applied as a high-throughput testing approach in the optimization of heat treatments.
Analysis of the Varying Thickness Rolling Process Based on the Principle of Pre-Displacement
Authors: Yang Shiyu , Liu Hongmin , Wang Dongcheng , Wang Guodong , Cao Xiaozheng
Published: October 2023

This paper conducts a comprehensive analysis of the varying thickness rolling process, grounded in the principle of pre-displacement. Within the rolling deformation zone, the subject is divided into three distinct areas: the backward slip zone, sticking zone, and forward slip zone. We propose a model that delineates the sticking-sliding motion between the rolled piece and the roller, all within the context of the rolling deformation zone, and derive a calculation method for determining the longitudinal lengths of both the sliding and sticking zones within this area. Unlike existing full sliding and full sticking models, our sticking-sliding model offers a novel perspective, overcoming inherent limitations when analyzing the rolling process. Furthermore, we establish models to describe the neutral angle and forward slip value and to predict the longitudinal length of the rolled piece during the varying thickness rolling process. A comparison of our calculated results with experimental data demonstrates the feasibility and effectiveness of the method, thereby laying a robust theoretical foundation for the varying thickness rolling process.
Wake-Up Free Ultrathin Ferroelectric Hf0.5Zr0.5O2 Films
Authors: Chouprik Anastasia , Mikheev Vitalii , Korostylev Evgeny , Kozodaev Maxim , Zarubin Sergey , Vinnik Denis , Gudkova Svetlana , Negrov Dmitrii
Published: October 2023

The development of the new generation of non-volatile high-density ferroelectric memory requires the utilization of ultrathin ferroelectric films. The most promising candidates are polycrystalline-doped HfO2 films because of their perfect compatibility with silicon technology and excellent ferroelectric properties. However, the remanent polarization of HfO2 films is known to degrade when their thickness is reduced to a few nanometers. One of the reasons for this phenomenon is the wake-up effect, which is more pronounced in the thinner the film. For the ultrathin HfO2 films, it can be so long-lasting that degradation occurs even before the wake-up procedure is completed. In this work, an approach to suppress the wake-up in ultrathin Hf0.5Zr0.5O2 films is elucidated. By engineering internal built-in fields in an as-prepared structure, a stable ferroelectricity without a wake-up effect is induced in 4.5 nm thick Hf0.5Zr0.5O2 film. By analysis of the functional characteristics of ferroelectric structures with a different pattern of internal built-in fields and their comparison with the results of in situ piezoresponse force microscopy and synchrotron X-ray micro-diffraction, the important role of built-in fields in ferroelectricity of ultrathin Hf0.5Zr0.5O2 films as well as the origin of stable ferroelectric properties is revealed.
Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
Authors: Huang Jingxi , Cheng Chen , Yang Youwen , Zan Jun , Shuai Cijun
Published: October 2023

The integration of hydroxyapatite (HA) with broad-spectrum bactericidal nano-silver within biopolymer-based bone scaffolds not only promotes new bone growth, but also effectively prevents bacterial infections. However, there are problems such as a poor interface compatibility and easy agglomeration. In this project, zeolitic imidazolate frameworks (ZIF-8) were grown in situ on nano-HA to construct a core–shell structure, and silver was loaded into the ZIF-8 shell through ion exchange. Finally, the core–shell structure (HA@Ag) was composited with polylactic acid (PLLA) to prepare bone scaffolds. In this case, the metal zinc ions of ZIF-8 could form ionic bonds with the phosphate groups of HA by replacing calcium ions, and the imidazole ligands of ZIF-8 could form hydrogen bonds with the carboxyl groups of the PLLA, thus enhancing the interface compatibility between the biopolymers and ceramics. Additionally, the frame structure of MOFs enabled controlling the release of silver ions to achieve a long-term antibacterial performance. The test results showed that the HA@Ag nanoparticles endowed the scaffold with good antibacterial and osteogenic activity. Significantly, the HA@Ag naoaprticle exhibited a good interfacial compatibility with the PLLA matrix and could be relatively evenly dispersed within the matrix. Moreover, the HA@ZIF-8 also effectively enhanced the mechanical strength and degradation rate of the PLLA scaffold.
The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
Authors: Ohmori Hiromitsu , Kato Akihiko , Shirai Yuka , Fukano Reiji , Nagae Akiko , Yamasaki Masami , Komenaka Junko , Imamura Eiji , Kumode Masao , Miyachi Takafumi
Published: October 2023

Nutritional support is essential for patients with severe motor and intellectual disabilities (SMID) to ensure the smooth provision of medical care. These patients often require long-term tube feeding with enteral formulas, potentially leading to deficiencies in vitamins and trace elements. Additionally, frequent antibiotic use for infections often disrupts gut microbiota, inhibiting vitamin K2 production by intestinal bacteria. We assessed the serum protein induced by vitamin K absence or antagonists-II (PIVKA-II) and undercarboxylated osteocalcin (ucOC) levels to assess the vitamin K status in 20 patients with SMID (median age: 44.1 years, 11 men and 9 women) undergoing long-term tube feeding for durations ranging from 3 to 31 years. Thirteen (65%) and nine (45%) patients had elevated PIVKA-II (<40 mAU/mL) and serum ucOC levels (reference value < 4.50 ng/mL), respectively. Dietary vitamin K1 intake did not differ between patients with and without elevated PIVKA-II levels. Vitamin K2 supplementation for 3 months decreased serum PIVKA-II levels near those within the reference range. Approximately half of the patients with SMID on tube feeding had subclinical vitamin K deficiency. Further studies are needed to ascertain if long-term vitamin K2 supplementation effectively prevents vitamin K deficiency-induced hypercoagulation, osteoporosis, and vascular calcification in patients with SMID.
Coordination of m6A mRNA Methylation and Gene Transcriptome in Sugarcane Response to Drought Stress
Authors: Wei Jinju , Li Haibi , Gui Yiyun , Zhou Hui , Zhang Ronghua , Zhu Kai , Liu Xihui
Published: October 2023

The N6-methyladenosine (m6A) methylation of mRNA is involved in biological processes essential for plant growth. To explore the m6A modification of sugarcane and reveal its regulatory function, methylated RNA immunoprecipitation sequencing (MeRIP-seq) was used to construct the m6A map of sugarcane. In this study, m6A sites of sugarcane transcriptome were significantly enriched around the stop codon and within 3′-untranslated regions (3′UTR). Gene ontology (GO) analysis showed that the m6A modification genes are associated with metabolic biosynthesis. In addition, the m6A modification of drought-resistant transcript mRNA increased significantly under drought (DR) treatment, resulting in enhanced mRNA stability, which is involved in regulating sugarcane drought resistance. GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment results showed that differentially methylated peak (DMP) modification of differentially expressed genes (DEGs) in DR were particularly associated with abscisic acid (ABA) biosynthesis. The upregulated genes were significantly enriched in the ABA metabolism, ethylene response, fatty acid metabolism, and negative regulation of the abscisic acid activation signaling pathway. These findings provide a basis and resource for sugarcane RNA epigenetic studies and further increase our knowledge of the functions of m6A modifications in RNA under abiotic stress.
The Effects of Accompanying Ryegrass on Bayberry Trees by Change of Soil Property, Rhizosphere Microbial Community Structure, and Metabolites
Authors: Li Changxin , Li Gang , Qi Xingjiang , Yu Zheping , Abdallah Yasmine , Ogunyemi Solabomi Olaitan , Zhang Shuwen , Ren Haiying , Mohany Mohamed , S. Al-Rejaie Salim , Li Bin , Liu Erming
Published: October 2023

As a subtropical and tropical tree, bayberry (Myrica rubra) is an important fruit tree grown commercially in southern China. Interestingly, our studies found that the fruit quality of bayberry with accompanying ryegrass was significantly improved, but its mechanism remains unclear. The aim of this study was to explore the mechanism of accompanying ryegrass on the beneficial effect of the fruit quality of bayberry by measuring the vegetative growth parameters, fruit parameters with economic impact, physical and chemical properties of rhizosphere soil, microbial community structure, and metabolites of the bayberry with/without ryegrass. Notably, the results revealed a significant difference between bayberry trees with and without accompanying ryegrass in fruit quality parameters, soil physical and chemical properties, microbial community structure, and metabolites. Compared with the control without accompanying ryegrass, the planting of ryegrass increased the titratable sugar, vitamin C, and titratable flavonoid contents of bayberry fruits by 2.26%, 28.45%, and 25.00%, respectively, and decreased the titratable acid contents by 9.04%. Furthermore, based on 16S and ITS amplicon sequencing of soil microflora, the accompanying ryegrass caused a 12.47% increment in Acidobacteriota while a 30.04% reduction in Actinobacteria was recorded, respectively, when compared with the bayberry trees without ryegrass. Redundancy discriminant analysis of microbial communities and soil properties indicated that the main variables of the bacterial community included available nitrogen, available phosphorus, exchangeable aluminum, and available kalium, while the main variables of the fungal community included exchangeable aluminum, available phosphorus, available kalium, and pH. In addition, the change in microbial community structure was justified by the high correlation analysis between microorganisms and secondary metabolites. Indeed, GC-MS metabolomics analysis showed that planting ryegrass caused a 3.83%–144.36% increase in 19 metabolites such as 1,3-Dipentyl-heptabarbital and carbonic acid 1, respectively, and a 23.78%–51.79% reduction of 5 metabolites compared to the bayberry trees without the accompanying ryegrass. Overall, the results revealed the significant change caused by the planting of ryegrass in the physical and chemical properties, microbiota, and secondary metabolites of the bayberry rhizosphere soils, which provides a new insight for the ecological improvement of bayberry.