bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates
Authors: Al Motwaa Sahar M. , Al‐Otaibi Waad A. , Abubakr Amrajaa S. , Rashidi Fatma B. , Hassan Safaa S.
Published: April 2024

Oxovanadium (IV) and diphenyltin (IV) complexes were synthesized on the nanoscale based on the Schiff base (H2L) derived from salicylaldehyde and d‐glucosamine. The complexes were formed with a molar ratio of 1:1 and 1:2 (metal: dligand) relative to oxovanadium (IV) and diphenyltin (IV), respectively. Fourier‐transform infrared spectroscopy, 1H and 13C nuclear magnetic resonance, mass fragmentations, electronic transitions, thermogravimetric analysis, and density functional theory were employed to validate the structure of synthesized compounds. The results demonstrated that the ligand (H2L) was successfully attached to oxovanadium (IV) and diphenyltin (IV) as di‐anionic and mono‐anionic ligands, respectively. The size of the complexes was investigated using the transmission scanning microscope. The work presents a prospective concept for the drug design of the targeted anticancer through the glucose moiety. All compounds revealed remarkable anticancer activities against the colorectal (HCT‐116) cell line, recording IC50 values 4.94, 21.73, and 62.5 μg/ml for VO (II)(L), free H2L, and Sn (ph)2(HL)2, respectively. The IC50 value of VO (II)(L) complex was increased after the quercetin inhibitor. Therefore, the sugar‐conjugated compound can be recognized by the glucose recognition binding site of GLUT and their cell‐killing effect depends highly on the GLUT inhibitor, quercetin. The potential GLUT transportability of the compounds was investigated through a molecular docking study. The anti‐migration activity was investigated for VO (II)(L) complex. The free ligand observed the best antimicrobial results. The antibacterial stimulation was investigated and represented different interaction types with the selected ribosyl transferase enzyme.
Development of new thiazole‐guanidine complexes as rapid and recoverable catalysts for the synthesis of 6‐piperidin‐dihydro‐thia‐hexaaza‐s‐indacene derivatives supported by DFT studies
Authors: El‐Remaily Mahmoud Abd El Aleem Ali Ali , Elhady Omar , Alzubi Mohammad Saleh Hussein , Eskander Thomas Nady A. , El Hamd Mohamed A. , Al‐Ghamdi Khalaf , Abu‐Dief Ahmed M.
Published: April 2024

In this study, the focus was on synthesizing metal chelates of Fe(III), Ni(II), and Pd(II) using thiazole‐guanidine derivatives. Various spectral and analytical methods were employed to elucidate the structural characteristics and determine the molecular formulae of these metal chelates, including infrared (IR(, 1H‐NMR and 13C‐NMR, ultraviolet–visible (UV–vis), CHN, XRD data, mass spectrometry, thermal conduction, and measures of magnetism, were used to clarify the structures of these compounds. The optimized molecular structures have been scrutinized by the DFT method. Correlation between all spectroscopic methods and DFT calculation revealed an octahedral‐coordinating environment surrounding the Fe3+ ion, [Fe (BTG)2(NO3)2].NO3.2H2O and Ni2+, [Ni (BTG)2(NO3)2].H2O cation and distorted square planner surrounding Pd2+, [Pd (BTG) (COOCH3)2].2H2O cation. The examination of the stability and stoichiometry of complexes in solution using conventional techniques has been incorporated into the investigation's scope. Under mild reaction conditions, the green technique was employed to carry out a condensation reaction for aromatic aldehyde, rhodanine, pipredine, and 5‐aminotetrazol to generate derivatives of 6‐piperidin‐dihydro‐thia‐hexaaza‐s‐indacene derivatives. In comparison to our new complexes, all reaction conditions were optimized for those variable Lewis acid catalysts. In general, tests conducted under high yield, speedy, and environmentally friendly solvent (H2O/EtOH) conditions, the BTGPd catalyst showed superiority over others. Additionally, the hetero‐catalyst recovery proved successful and could be employed with the same efficiency up to six times before the efficiency started to decrease. The effectiveness of this catalytic procedure was validated through a thorough examination using density functional theory (DFT). The DFT analysis showcased the distinctive characteristics of this complex and proposed logical mechanisms that elucidated the crucial physical parameters responsible for the superior catalytic performance of the Pd(II) complex.
Scale inhibition performance of carboxylic acid polymers containing ether groups in artificial seawater: Experiments and MD simulation
Authors: Zhang Jiajia , Sun Xueni , Shao Hui
Published: April 2024

The lowered dispersibility of carboxylic acid polymers in the seawater system with high salt content results in reduced scale inhibition efficiency. To solve this problem, a series of carboxylic acid polymers containing ether groups were prepared by free radical polymerization using α‐allyl glycerol ether (AG) and vinyl monomers containing different numbers of carboxylic acid groups (acrylic acid [AA], maleic acid [MA], itaconic acid [IA], and aconitic acid [ANA]) as raw materials, and their scale inhibition properties in artificial seawater were studied. The static test results demonstrate that IA‐AG outperforms the other three polymers containing ether carboxylic acid in terms of scale inhibition performance, with CaCO3 and CaSO4 having scale inhibition rates of 95.16% and 98.73%, respectively. Furthermore, molecular dynamics (MD) simulation was employed to investigate the mechanism of scale inhibition by simulating the interaction between ether carboxylic acid polymers and the crystal surface. The results show that the order of binding energy between polymers and crystal faces is IA‐AG > ANA‐AG > MA‐AG > AA‐AG. The simulation results are in agreement with the experimental phenomena. The polymers can overcome their own deformation and adsorb on the crystal surfaces, thus inhibiting the growth of scale.
Preparation of Ti4O7/h‐BN self‐supported ceramic photoelectrode and its photoelectrocatalytic performance for water purification
Authors: Li Shanshan , Gong Yanan , Hossain Md Azharul , Jiang Zeqi , Zhang Jiarong , Wang Guowen , Fu Yinghuan , Wang Pengyuan , Song Yu , Ma Hongchao
Published: April 2024

The construction of high‐efficiency self‐supported ceramic photoelectrode based on ideal semiconductor materials is essential for achieving effective degradation of pollutants by photoelectrocatalysis (PEC) technology. Herein, a Ti4O7/h‐BN composite ceramic photoelectrode with a unique microstructure was fabricated by a step‐by‐step calcination process and used in PEC water pollution remediation. The PEC activity of Ti4O7 ceramic photoelectrode could be enhanced by introducing hexagonal boron nitride (h‐BN) nanoparticles on the surface. The most optimized Ti4O7/h‐BN photoelectrode exhibited the decolorization rate of active brilliant blue KN‐R at about 97.79% in 30 min. The PEC activities could remain stable during five degradation cycles. The excellent photoelectrocatalytic performance of Ti4O7/h‐BN ceramic photoelectrode could be attributed to the low Tafel slope, low charge transfer resistance, large electrochemical active area, and excellent photo‐generated carrier separation efficiency. A type‐II heterojunction was formed between the Ti4O7 and h‐BN, which caused more effective carrier separation and enhanced the generation of dominant active species •O2− and h+. This work provided a mature synthesis strategy of Ti4O7/h‐BN self‐supported ceramic photoelectrodes with excellent practical application prospects to achieve superior PEC performance for water purification.
Anti‐solvent method synthesized phosphorylated microcapsules with flame retardancy and self‐healing analysis
Authors: Li Yadi , Meng Xiangbao , Song Shizemin , Qin Zhao , Zhu Yujian , Yu Xiaozhen , Wang Tong
Published: April 2024

In this study, an anti‐solvent method is employed to encapsulate linseed oil (LO) into phosphorylated ethyl cellulose (P‐EC), successfully preparing microcapsules (LO@P‐EC). Scanning electron microscopy and Fourier transform infrared spectroscopy experimental results indicate the introduction of phosphoric groups into P‐EC, and the successful encapsulation of LO within the microcapsules, which are spherical with an average diameter of 145 μm. Hartmann tests reveal that the introduction of phosphate groups reduces the microcapsule flame propagation height by 43.75% and the average flame propagation speed by 55.67%. Thermodynamic analyses based on the Coats‐Redfern equation are performed to determine the changes in activation energy during thermal degradation. Furthermore, fitting analysis shows that the apparent activation energy of microcapsules with shell material of P‐EC significantly increases, confirming the evident thermodynamic inhibition of microcapsule deflagration by P‐EC. This is mainly attributed to the formation of a char structure by the P‐EC shell during combustion, which hinders the progress of the combustion reaction. When immersed in 3.5 wt% NaCl corrosive solution for 15 days, the microcapsule‐filled epoxy resin (LO@P‐EC/EP) coating exhibits excellent corrosion resistance, which is mainly attributed to the excellent self‐healing properties of the microcapsule core LO.
New findings of dipteromantispids (Insecta: Neuroptera) from Upper Cretaceous Myanmar amber
Authors: Chen Cuixia , Peng Zihao , Shi Chaofan , Ren Dong , Yang Qiang
Published: April 2024

A new genus and two new species, Tholimantispa zuoae gen. et sp. nov. and Mantispidipterella curvis sp. nov. are described from the Upper Cretaceous of northern Myanmar amber collected in 2015. Tholimantispa zuoae gen. et sp. nov. is characterized by its distinct pterostigma, broad costal space, bifurcate humeral veinlets, and so forth, and Mantispidipterella curvis sp. nov. is different from Mantispidipterella longissima Liu, Lu et Zhang, 2017 in its ScP (subcosta posterior) distinctly curved at fusing point with RA (radius anterior), RP (radius posterior) abruptly and angularly curved at ra‐rp (crossvein between RA and RP), AA3 (third branches of the anterior anal vein) present. The new fossil species enrich the diversity of Dipteromantispidae in the Cretaceous.
Luminogenic and Bactericidal Studies of an Acrylonitrile‐Based AIEgen
Authors: De Sagnik , Ghosh Debolina , Das Gopal
Published: April 2024

We have synthesized an aggregation‐induced emissive molecule that exhibits promising photophysical characteristics. The aggregating aptitude is demonstrated by binary solvent mixture and it is emissive in both solution and solid state. The luminogenic characteristics are employed in creating fluorescent inks as well as for the detection of nitro antibiotics in biofluids and in solid support. Moreover, the acrylonitrile‐based compound is bactericidal tested on E. coli and B. subtilis.
Efficient Absorption of CO2 by Protic‐Ionic‐Liquid Based Deep Eutectic Solvents
Authors: Wen Shuyue , Zhang Xiaomin , Wu Youting
Published: April 2024

Carbon capture, utilization, and storage (CCUS) are among the key technologies to achieve large‐scale carbon emission reduction globally. Deep eutectic solvents (DESs) are considered as designable solvents, which has attracted intensive attention for CO2 capture. Here, a series of binary DESs are synthesized through one‐step mixing with the starting materials of protic ionic liquid (PIL) and amine. The eutectic behavior was investigated by measuring the melting point of PILs and amine. The saturated vapor of these DESs and industrial MDEA solution were measured and compared. These DESs are investigated to have high absorption capacity (0.1 g ⋅ g−1 at 1.0 bar and 25 °C), superior apparent absorption rate constant (0.381 min−1 vs 0.012 min−1 of 70 wt.% MDEA), moderate interaction with CO2 (the enthalpy change is as low as −34.8 kJ ⋅ mol−1). The absorption mechanism is also investigated by NMR analysis. Eight absorption/desorption regeneration experiments are carried out to show their reversibility. Considering the advantages, including convenience of synthesis, large absorption capacity, fast absorption rate, and moderate interaction energy as well as good regeneration, these DESs are believed to be as potential CO2 absorbent in practical applications.
Emerging Halide Solid Electrolytes for Sodium Solid‐State Batteries: Structure, Conductivity, Paradigm of Applications
Authors: Wei Zhixuan , Nazar Linda F. , Janek Jürgen
Published: April 2024

Solid‐state sodium batteries (SSSBs) hold great promise for the development of safe, low‐cost energy storage devices. Developing solid electrolyte (SE) materials with high ionic conductivity, high chemical and electrochemical stability, as well as good mechanical properties is the most critical step. As a promising category of SEs, halide‐based solid electrolytes combine good ionic conductivity and good electrochemical stability, and they have been already widely studied for their use in lithium‐based solid‐state batteries. In contrast, knowledge of their sodium analogues is still limited. Here, we provide a comprehensive overview of halide SEs for sodium ion conduction with a perspective of both experimental and theoretical studies, including the correlation of structure and properties; sodium ion conductivity and diffusivity; as well as compatibility with electrode materials. We hope this perspective can stimulate more research in developing halide‐based SSSBs.
Comparative evaluation of open book and conventional assessment methods in medical undergraduate students
Authors: Irungbam Monica , Prisi Shailata , Shrivastava Ritika , Goswami Binita
Published: April 2024

Medical science is a dynamic field of knowledge that is constantly broadening with upcoming clinical research and analysis. Traditional medical education has been focused on textbook‐based recall assessments—closed book assessment (CBA). However, the availability of newer technologies has made the accessibility to encyclopedic knowledge expeditious, which demands for a new approach for medical education. As medical professionals, the purpose of learning should be higher cognitive skills such as interpretation and synthesis. So, analyzing students’ ability to comprehend the concepts and learning to apply it in a realistic context than merely recalling the facts has come into attention. In this study, we aimed to evaluate and compare the performance of 250 first‐year MBBS students at Maulana Azad Medical College, New Delhi, India, between closed book and open book method for biochemistry. Students were divided into two groups, Group A and Group B, based on their average monthly internal assessment marks. CBA was followed by open book assessment (OBA) 1 week apart with similar questionnaire pattern and allotted time. A significant difference in average marks obtained by the two groups was observed in CBA. Group A scored better in CBA, but performance was comparable with Group B in OBA. OBA and CBA can contribute to an assessment program in part because of their complementary pros and cons, and OBA should not be thought of as an alternative to CBA, but their value may be in expanding beyond what is measured by CBA.
Preservation of the heart in ancient Egyptian mummies: A computed tomography investigation with focus on the myocardium
Authors: Panzer Stephanie , Paladin Alice , Zesch Stephanie , Rosendahl Wilfried , Augat Peter , Thompson Randall C. , Miyamoto Michael I. , Sutherland M. Linda , Allam Adel H. , Wann L. Samuel , Sutherland James D. , Rowan Chris J. , Michalik David E. , Hergan Klaus , Zink Albert R.
Published: April 2024

The ancient Egyptians considered the heart to be the most important organ. The belief that the heart remained in the body is widespread in the archeological and paleopathological literature. The purpose of this study was to perform an overview of the preserved intrathoracic structures and thoracic and abdominal cavity filling, and to determine the prevalence and computed tomography (CT) characteristics of the myocardium in the preserved hearts of ancient Egyptian mummies. Whole‐body CT examinations of 45 ancient Egyptian mummies (23 mummies from the Ägyptisches Museum und Papyrussammlung, Berlin, Germany, and 22 mummies from the Museo Egizio, Turin, Italy) were systematically assessed for preserved intrathoracic soft tissues including various anatomical components of the heart (pericardium, interventricular septum, four chambers, myocardium, valves). Additionally, evidence of evisceration and cavity filling was documented. In cases with identifiable myocardium, quantitative (measurements of thickness and density) and qualitative (description of the structure) assessment of the myocardial tissue was carried out. Heart structure was identified in 28 mummies (62%). In 33 mummies, CT findings demonstrated evisceration, with subsequent cavity filling in all but one case. Preserved myocardium was identified in nine mummies (five male, four female) as a mostly homogeneous, shrunken structure. The posterior wall of the myocardium had a mean maximum thickness of 3.6 mm (range 1.4–6.6 mm) and a mean minimum thickness of 1.0 mm (range 0.5–1.7 mm). The mean Hounsfield units (HU) of the myocardium at the posterior wall was 61 (range, 185–305). There was a strong correlation between the HU of the posterior wall of the myocardium and the mean HU of the muscles at the dorsal humerus (R = 0.77; p = 0.02). In two cases, there were postmortem changes in the myocardium, most probably due to insect infestation. To our knowledge, this is the first study to investigate the myocardium systematically on CT scans of ancient Egyptian mummies. Strong correlations between the densities of the myocardium and skeletal muscle indicated similar postmortem changes of the respective musculature during the mummification process within individual mummies. The distinct postmortem shrinking of the myocardium and the collapse of the left ventriclular cavity in several cases did not allow for paleopathological diagnoses such as myocardial scarring.
Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data
Authors: Luo Jiawen , Hu Jintao , Mulati Yelisudan , Wu Zhikai , Lai Cong , Kong Degeng , Liu Cheng , Xu Kewei
Published: April 2024

Objective

The primary aim of this study was to create a nomogram for predicting survival outcomes in penile cancer patients, utilizing data from the Surveillance, Epidemiology, and End Results (SEER) and a Chinese organization.

Methods

Our study involved a cohort of 5744 patients diagnosed with penile cancer from the SEER database, spanning from 2004 to 2019. In addition, 103 patients with penile cancer from Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University were included during the same period. Based on the results of regression analysis, a nomogram is constructed and validated internally and externally. The predictive performance of the model was evaluated by concordance index (c‐index), area under the curve, decision curve analysis, and calibration curve, in internal and external datasets. Finally, the prediction efficiency is compared with the TNM staging model.

Results

A total of 3154 penile patients were randomly divided into the training group and the internal validation group at a ratio of 2:1. Nine independent risk factors were identified, including age, race, marital status, tumor grade, histology, TNM stage, and the surgical approach. Based on these factors, a nomogram was constructed to predict OS. The nomogram demonstrated relatively better consistency, predictive accuracy, and clinical relevance, with a c‐index over 0.73 (in the training cohort, the validation cohort, and externally validation cohort.) These evaluation indexes are far better than the TNM staging system.

Conclusion

Penile cancer, often overlooked in research, has lacked detailed investigative focus and guidelines. This study stands as the first to validate penile cancer prognosis using extensive data from the SEER database, supplemented by data from our own institution. Our findings equip surgeons with an essential tool to predict the prognosis of penile cancer better suited than TNM, thereby enhancing clinical decision‐making processes.
Impact of vessel volume on thermodilution measurements in patients with coronary microvascular dysfunction
Authors: Sakai Koshiro , Storozhenko Tatyana , Mizukami Takuya , Ohashi Hirofumi , Bouisset Frederic , Tajima Atomu , van Hoe Lieven , Gallinoro Emanuele , Botti Giulia , Mahendiran Thabo , Pardaens Sofie , Brouwers Sofie , Fawaz Samer , Keeble Thomas R. , Davies John R. , Sonck Jeroen , De Bruyne Bernard , Collet Carlos
Published: April 2024

Background

Two invasive methods are available to estimate microvascular resistance: bolus and continuous thermodilution. Comparative studies have revealed a lack of concordance between measurements of microvascular resistance obtained through these techniques.

Aims

This study aimed to examine the influence of vessel volume on bolus thermodilution measurements.

Methods

We prospectively included patients with angina with non‐obstructive coronary arteries (ANOCA) undergoing bolus and continuous thermodilution assessments. All patients underwent coronary CT angiography to extract vessel volume. Coronary microvascular dysfunction was defined as coronary flow reserve (CFR) < 2.0. Measurements of absolute microvascular resistance (in Woods units) and index of microvascular resistance (IMR) were compared before and after volumetric adjustment.

Results

Overall, 94 patients with ANOCA were included in this study. The mean age was 64.7 ± 10.8 years, 48% were female, and 19% had diabetes. The prevalence of CMD was 16% based on bolus thermodilution, while continuous thermodilution yielded a prevalence of 27% (Cohen's Kappa 0.44, 95% CI 0.23–0.65). There was no correlation in microvascular resistance between techniques (r = 0.17, 95% CI −0.04 to 0.36, p = 0.104). The adjustment of IMR by vessel volume significantly increased the agreement with absolute microvascular resistance derived from continuous thermodilution (r = 0.48, 95% CI 0.31–0.63, p < 0.001).

Conclusions

In patients with ANOCA, invasive methods based on coronary thermodilution yielded conflicting results for the assessment of CMD. Adjusting IMR with vessel volume improved the agreement with continuous thermodilution for the assessment of microvascular resistance. These findings strongly suggest the importance of considering vessel volume when interpreting bolus thermodilution assessment.
Iron deficiency‐induced thrombocytosis presenting with blue toe syndrome
Authors: Aboujabal Khaled , Sadek Khaled , Obaid Koutaibah , Sawaf Bisher , Habas Elmukhtar , Habib Mhd Baraa
Published: April 2024

Key Clinical Message

Although the etiology of blue toe syndrome is varied, the association between blue toe syndrome and iron deficiency‐induced thrombocytosis (IDIT) has not been well established. We report the case of a 38‐year‐old Saudi male who presented with blue toe syndrome and laboratory investigations revealed severe thrombocytosis secondary to iron deficiency. The patient was managed with analgesics, antiplatelets, anticoagulation, intravenous fluids, and iron supplementation. Subsequently, his symptoms resolved within a few days. IDIT is crucial to consider as a possible cause of microvascular thrombosis disorders, especially in patients with severe thrombocytosis.
Weed control and rice response to microencapsulated acetochlor and a fenclorim seed treatment on a clay soil
Authors: Avent Tristen H. , Norsworthy Jason K.
Published: April 2024

Recent research has demonstrated the ability of a fenclorim seed treatment to reduce rice (Oryza sativa L.) injury to acetochlor. However, all studies were conducted on silt loam soils and have not evaluated rice tolerance or weed control on clay soils. Experiments were initiated in 2021 and 2022 at the Northeast Research and Extension Center near Keiser, AR, to determine rice response and the effectiveness of delayed‐preemergence (DPRE)‐applied microencapsulated (ME) acetochlor (1.1, 1.7, and 2.3 lb ai acre−1) when applied to a clay soil with and without a fenclorim seed treatment at 0 or 2.5 lb ai 1000‐lb−1 of seed. Averaged over the fenclorim seed treatment, acetochlor at 1.1 and 1.7 lb ai acre−1 caused similar injury levels to rice; however, barnyardgrass [Echinochloa crus‐galli (L.) P. Beauv.] control increased at 1.7 lb ai acre−1, eliciting 19% injury to rice and 82% barnyardgrass control at 28 days after emergence (DAE). Palmer amaranth (Amaranthus palmeri S. Watson) control ranged from 82% to 93%. Additionally, fenclorim did not influence barnyardgrass or Palmer amaranth control, but it did reduce rice injury and increase shoot density, plant height, and rough rice grain yield. At 14 and 28 DAE, fenclorim at 2.5 lb ai 1000‐lb−1 of seed (averaged over acetochlor rates) reduced visible rice injury from 61% to 13% and 40% to 8%, respectively. Results from this study indicate ME acetochlor could be successfully applied to rice grown on a clay soil when a fenclorim seed treatment is used, providing producers a new site of action for use in U.S. rice production.
Catalyst‐Free Synthesis of Thiosulfonates and 3‐Sulfenylindoles from Sodium Sulfinates in Water
Authors: Li Shaoke , Huang Zijun , Wang Xin , Yingxiong Hui , Niu Guohao , Chen Ziyan , Zhang Zhenlei
Published: April 2024

This paper presents a green and efficient aqueous‐phase method for the synthesis of thiosulfonates, which has the benefits of no need for catalysts or redox reagents and a short reaction time, providing a method with great economic value for synthesizing thiosulfonates. Furthermore, 3‐Sulfenylindoles can be easily synthesized using this method, which expands the potential applications of this reaction.
The need for multilevel supportive care infrastructure for cancer caregivers
Authors: McConnell Kelly M. , Shen Megan J.
Published: April 2024

Communication with cancer caregivers occurs in the broader multilevel context of oncology care. Improving communication with caregivers requires changes across multiple levels of this context.
Study on the evolutionary characteristics of strain energy on crack propagation in coal and rock under bending load
Authors: Zhang Yueying , Zhang Dongxiao , Gong Xufei , Zhang Wei , Zhang Lei
Published: April 2024

The failure of coal mine overburden is mainly caused by fractures under bending loads. The energy evolution characteristics of coal and rock fractures are closely related to coal mine disasters such as rock burst. To obtain the characteristics of energy release and accumulation of coal and rock under bending load, three‐point bending tests of coal, mudstone, and sandstone were carried out respectively. The strength characteristics and fracture propagation process of coal and rock under bending load were studied. The strain energy evolution rules of coal and rock were calculated and obtained. The fracture mechanism of coal and rock was discussed by analyzing the critical strain energy release rate. The results show that the fracture complexity of sandstone and mudstone is greater than that of coal. The microstructure and its directivity in coal and rock indirectly affect their fracture characteristics through the elastic modulus characteristics. The distribution of parameters such as peak load of fracture, fracture energy, and crack length of coal and mudstone samples is discrete, while that of sandstone samples is concentrated. The deformation energy density of coal and rock basically shows a linear increase trend at the prepeak stage. The deformation energy density evolution characteristics at the postpeak stage are mainly affected by the load drop. It is important to establish the internal relationship between the meso structural characteristics and macro mechanical properties for solving engineering problems.
Total Synthesis of Core 3 & Core 4‐Type Mucin Glycan Derivatives
Authors: Cori Carmen R. , Hevey Rachel
Published: April 2024

Recent studies have demonstrated the ability of mucin O‐glycans to attenuate virulence in diverse, cross‐kingdom pathogens, sparking interest in their development as a novel therapeutic approach against infection. Although their virulence attenuating activity is evident, mucin glycans obtained from native sources comprise mixtures of several hundred distinct structures, and therefore the specific active glycan epitopes and molecular mechanisms of virulence attenuation remain unclear. Individual mucin glycan structures cannot be purified from native sources and are not amenable to automated synthesis; therefore, to further investigate the phenomena of virulence attenuation we have been developing convergent and scalable methods (>30 mg per target glycan) to assemble a mucin O‐glycan library in sufficient scale and purity to facilitate biological studies. Previously we described a method to obtain core 1 & core 2‐type mucin glycan derivatives that have since been used to identify active epitopes in Candida albicans and Vibrio cholerae. In the current study, we describe the expansion of our glycan library to include core 3 & core 4‐type derivatives, increasing the structural diversity of our platform for biological evaluation.
Community engagement and social participation in dengue prevention: A cross‐sectional study in Dhaka City
Authors: Hossain Md Jubayer , Das Manisha , Islam Md Wahidul , Shahjahan Muhibullah , Ferdous Jannatul
Published: April 2024

Background

Dengue is a major public health concern in Bangladesh. This study aimed to assess the perceptions and practices of community members in Dhaka regarding community engagement and social participation for dengue prevention.

Methods

A cross‐sectional online survey was conducted in Dhaka City from May 2022 to December 2022. The respondents were randomly selected. The association between community participation and prevention practices was tested using the χ2 test.

Results

The findings of this study indicate that the majority of participants (92%) believed that community effort would be relied upon in the event of a dengue outbreak. Environmental cleaning campaigns were the preferred approach, and religious leaders viewed them positively. This study also revealed significant variations in knowledge levels, with those involved in community efforts and mass gatherings demonstrating greater knowledge. This study sheds light on the demographic factors that influence dengue knowledge and provides valuable insights into the development of targeted public health interventions.

Conclusion

The study revealed negative perceptions and limited participation in dengue prevention among participants, with the majority demonstrating a poor understanding of preventive measures. While some showed positive attitudes towards community engagement, significant disparities existed in participation, highlighting the need for targeted educational campaigns and enhanced community mobilization efforts. Moreover, the importance of multisectoral collaboration is emphasized, underscoring the need for coordinated efforts among health departments, NGOs, religious institutions, and community leaders to effectively combat dengue transmission. Recommendations include ongoing educational initiatives, targeted interventions to promote community involvement, and fostering collaboration across sectors to strengthen dengue prevention efforts and to safeguard public health.
Observations of reduced ET and persistent elevated water table beneath a riparian forest gap following emerald ash borer invasion and tree mortality
Authors: Krzemien Sarah , Robertson Wendy M. , Engelken Patrick J. , McCullough Deborah G.
Published: April 2024

Emerald ash borer (EAB) (Agrilus planipennis Fairmaire), an invasive, phloem‐feeding beetle native to Asia, has killed millions of ash (Fraxinus spp.) trees in North America since it was detected in southeast Michigan in 2002. Consistently high mortality of black ash (Fraxinus nigra) and green ash (F. pennsylvanica) which often occur in riparian forests is a concern given their role in regulating soil moisture and shallow groundwater levels. We monitored and compared hydrologic processes in a riparian forest impacted by EAB invasion and an adjacent unimpacted riparian forest site in southwest Michigan. From 2018 to 2022, we recorded soil moisture, depth to groundwater and meteorological variables at 15‐min intervals throughout the growing season in a canopy gap following EAB‐caused ash mortality and in adjacent, unaffected forest in the Augusta Creek riparian zone. Groundwater contributions to evapotranspiration (ETG) were estimated using a groundwater level fluctuation (WLF) method. Significant differences in volumetric soil moisture content (16%–26% higher in the gap than forest), average depth to water (10 cm in the gap vs. 70 cm below land surface in the forest) and mean daily ETG (0.6 in the gap vs. 3.0 mm per day in the forest) persisted across four growing seasons. Within the gap, prolonged saturation of the near surface may be contributing to a shift from a forested riparian ecosystem to herb and sedge‐dominated wetland. These differences have implications for an array of riparian zone ecosystem services, a concern given the extent of ash mortality already sustained in much of eastern North America.
Time‐specific impact of trace metals on breast density of adolescent girls in Santiago, Chile
Authors: Kim Claire E. , Pereira Ana , Binder Alexandra M. , Amarasiriwardena Chitra , Shepherd John A. , Corvalan Camila , Michels Karin B.
Published: April 2024

Whether trace metals modify breast density, the strongest predictor for breast cancer, during critical developmental stages such as puberty remains understudied. Our study prospectively evaluated the association between trace metals at Tanner breast stage B1 (n = 291) and at stages both B1 and B4 (n = 253) and breast density at 2 years post‐menarche among Chilean girls from the Growth and Obesity Cohort Study. Dual‐energy x‐ray absorptiometry assessed the volume of dense breast tissue (absolute fibroglandular volume [FGV]) and percent breast density (%FGV). Urine trace metals included arsenic, barium, cadmium, cobalt, cesium, copper, magnesium, manganese, molybdenum, nickel, lead, antimony, selenium, tin, thallium, vanadium, and zinc. At B1, a doubling of thallium concentration resulted in 13.69 cm3 increase in absolute FGV (β: 13.69, 95% confidence interval [CI]: 2.81, 24.52), while a doubling of lead concentration resulted in a 7.76 cm3 decrease in absolute FGV (β: –7.76, 95%CI: −14.71, −0.73). At B4, a doubling of barium concentration was associated with a 10.06 cm3 increase (β: 10.06, 95% CI: 1.44, 18.60), copper concentration with a 12.29 cm3 increase (β: 12.29, 95% CI: 2.78, 21.56), lead concentration with a 9.86 cm3 increase (β: 9.86, 95% CI: 0.73, 18.98), antimony concentration with a 12.97 cm3 increase (β: 12.97, 95% CI: 1.98, 23.79) and vanadium concentration with a 13.14 cm3 increase in absolute FGV (β: 13.14, 95% CI: 2.73, 23.58). Trace metals may affect pubertal breast density at varying developmental stages with implications for increased susceptibility for breast cancer.
Trends in the incidence of colorectal cancer in sub‐Saharan Africa: A population‐based registry study
Authors: Moen Laura , Liu Biying , Bukirwa Phiona , Chingonzoh Tatenda , Chokunonga Eric , Finesse Anne , Korir Ann , Lamin Bojang , Lorenzoni Cesaltina Ferreira , Manraj Shyam S. , N'Da Guy , Odzebe Anani Wencesl Severin , Ogunbiyi Olufemi , Somdyala Nontuthuzelo I. M. , Packzowski Magdalena , Parkin Donald M.
Published: April 2024

In sub‐Saharan Africa, colorectal cancer (CRC) has historically been considered a rare disease, although some previous studies have suggested that the incidence is increasing. We examine time trends in the incidence of CRC using data from 12 population‐based cancer registries in 11 countries of sub‐Saharan Africa that were able to provide time series data for periods of 12 or more years, or with earlier data with which recent rates may be compared. Age‐standardized incidence rates were highest in the higher‐income countries, and were increasing in all of the populations studied, and these increases were statistically significant in all but three. Current evidence has suggested a link between the increased adoption of western lifestyle habits with colorectal cancer, and along with increasing urbanization of African populations, there is an increase in body weight, as well as evidence of increasing consumption of meat, sugars, and alcohol.
Ammonia measurement in human breath of subjects with Helicobacter pylori using photoacoustic spectroscopy
Authors: Popa Cristina , Petrus Mioara , Bratu Ana Maria
Published: April 2024

Helicobacter pylori (H. pylori) is a type of bacteria that infects the stomach. The detection of H. pylori is an essential part of current clinical practices because this disease can cause peptic ulcers, chronic inflammation of the stomach lining but also stomach cancer. Helicobacter pylori has a naturally occurring enzyme that hydrolyzes urea into ammonium carbonate called urease. Many methods exist for the detection of H. pylori infection, but an innovative approach is to detect the ammonia in the breath (ABT, Ammonia Breath Test). In this research study, using photoacoustic spectroscopy method, the ammonia concentration in the breathing zone of people with H. pylori were measured and were compared with ammonia concentration from the respiration of healthy people. From the ABT determinations of this study, the ammonia was established to be increased with 498 ppb at people with H. pylori when we compare with ABT of healthy people.
Discovering trends in the Lewis acidity of beryllium and magnesium hydrides and fluorides with increasing clusters size
Authors: Mó Otilia , Montero‐Campillo M. Merced , Yáñez Manuel , Alkorta Ibon , Elguero José
Published: April 2024

We have reported in the last years the strong effect that Be‐ and Mg‐containing Lewis acids have on the intrinsic properties of typical bases, which become acids upon complexation. In an effort to investigate these changes when the Be and Mg derivatives form clusters of increasing size, we have examined the behavior of the (MX2)n (M = Be, Mg; X = H, F; n = 1, 2, 3) clusters when they interact with ammonia, methanimine, hydrogen cyanide and pyridine, and with their corresponding deprotonated forms. The complexes obtained at the M06‐2X/aug‐cc‐pVTZ level were analyzed using the MBIE energy decomposition formalism, in parallel with QTAIM, ELF, NCIPLOT and AdNDP analyses of their electron density. For n = 1 the interaction enthalpy for the different families of monomers, Be (Mg) hydrides and Be (Mg) fluorides, follows the same trend as the intrinsic basicity of the base that interacts with them. This interaction is greatly reinforced after the deprotonation of the base, resulting in a significant enhancement of the intrinsic acidity of the corresponding MX2–Base complex. For (MX2)2 clusters a further reinforcement of the interaction with the base is observed, this reinforcement being again larger for the deprotonated complexes. However, the concomitant increase of their intrinsic acidity is one order of magnitude larger for hydrides than for fluorides. Unexpectedly, the cyclic conformers (MX2)3, which are more unstable than the linear ones, become the global minima after association with the base and the same is true for the deprotonated complex. Accordingly, a further increase of the intrinsic acidity of the (MX2)3–Base complexes with respect to the (MX2)2–Base ones is observed. This effect is maximum for (MgF2)3 clusters, to the point that the (MgF2)3–Base complexes become more acidic than nitric acid, the extreme case being the cluster (MgF2)3–NCH, whose acidity is higher than that of perchloric acid.
A qualitative study of military service members undergoing medical separation
Authors: Lee‐Tauler Su Yeon , LaCroix Jessica M. , Huppert Tierney K. , Winters Amber M. , Stivers Max , Arellano‐Euribe A. Penelope , Grammer Joseph , Cobb Erin , Alvarado Kathryn J. , Boyd David , Patterson Lee E. , Golle Mario F. , Ghahramanlou‐Holloway Marjan
Published: April 2024

Objective

Little research explores military perspectives on medical disability‐related transition. A qualitative study sought to understand transition experiences of United States military Service members found unfit for duty following medical and physical evaluation boards (MEBs and PEBs).

Methods

Confidential telephone interviews were conducted with 25 current and prior Service members. Participants were asked to share their experiences before, during, and after the MEB and PEB processes. Interview questions explored (1) health conditions that prompted the medical disability evaluation, (2) reactions to being recommended for separation, (3) transition‐related stress and challenges, and (4) coping strategies. Salient themes were identified across chronological narratives.

Results

Participants expressed that debilitating physical (e.g., injury) and/or mental (e.g., post‐traumatic stress disorder) illnesses prompted their medical evaluation. In response to the unfit for duty notice, some participants reported emotional distress (e.g., anxiety, anger) connected to uncertainty about the future. Other participants reported relief connected to a sense of progression toward their medical disability claim status. Transition stress included the length of the MEB/PEB process, impact of the COVID‐19 pandemic on the process, financial stress, impact on family life, and compounded effect of these stressors on emotional distress, including depression and suicidal thoughts. Participants reported using adaptive (e.g., psychotherapy) and maladaptive (e.g., excessive drinking) strategies to cope with stress.

Conclusion

Preliminary reports of emotional distress and transition stress following unfit for duty notices highlight the need for increased support and interventions to facilitate adaptive coping strategies during this vulnerable period.
Mental health and suicide among youth residing in frontier and remote areas
Authors: Kreuze Elizabeth
Published: April 2024

Aims

Examine state‐level data from the National Survey of Children's Health (NSCH), Youth Risk Behavior Surveillance System (YRBSS), and frontier and remote area (FAR) codes. Compare state‐level data from the NSCH and YRBSS to state's FAR codes, to explore correlations between youth mental health/suicide and geographic remoteness.

Methods

State‐level data from the NSCH, YRBSS and FAR codes were organized into tables. For each variable, states were ranked from 1 to 50 and assigned a numeric value. Using this numeric ranking system, Kendall's tau‐b was used to examine correlations between NSCH data and FAR codes, and YRBSS data and FAR codes.

Results

There were no significant correlations between any FAR level and any NSCH variable. There were significant correlations between level 1 FAR areas and suicidal ideation, suicide planning, and suicide attempt. There were also significant correlations between FAR levels 2, 3, and 4 and suicidal ideation and suicide planning.

Conclusion

Continued surveillance of youth mental health is important in building the evidence base. However, because suicidal ideation and suicide planning appear higher across all FAR levels, there is opportunity to implement sustainable approaches to prevent suicidal behaviors among youth in FAR areas.
Expression of honey bee (Apis mellifera) sterol homeostasis genes in food jelly producing glands of workers
Authors: Yusuf Abdullahi A. , Pirk Christian W. W. , Buttstedt Anja
Published: April 2024

Adult workers of Western honey bees (Apis mellifera L.) acquire sterols from their pollen diet. These food sterols are transported by the hemolymph to peripheral tissues such as the mandibular and the hypopharyngeal glands in the worker bees' heads that secrete food jelly which is fed to developing larvae. As sterols are obligatory components of biological membranes and essential precursors for molting hormone synthesis in insects, they are indispensable to normal larval development. Thus, the study of sterol delivery to larvae is important for a full understanding of honey bee larval nutrition and development. Whereas hypopharyngeal glands only require sterols for their membrane integrity, mandibular glands add sterols, primarily 24‐methylenecholesterol, to its secretion. For this, sterols must be transported through the glandular epithelial cells. We have analyzed for the first time in A. mellifera the expression of genes which are involved in intracellular movement of sterols. Mandibular and hypopharyngeal glands were dissected from newly emerged bees, 6‐day‐old nurse bees that feed larvae and 26‐day‐old forager bees. The expression of seven genes involved in intracellular sterol metabolism was measured with quantitative real‐time PCR. Relative transcript abundance of sterol metabolism genes was significantly influenced by the age of workers and specific genes but not by gland type. Newly emerged bees had significantly more transcripts for six out of seven genes than older bees indicating that the bulk of the proteins needed for sterol metabolism are produced directly after emergence.
Unusually weak signal of summer surface air temperature change over North China
Authors: Cheng Fangyuan , Zuo Zhiyan , Zhang Kaiwen , Chang Meiyu , Xiao Dong
Published: April 2024

Under global warming, the summer surface air temperature (SAT) change signal in the northern mid‐latitudes is generally the most significant, while the SAT change in North China (NC) shows distinct local characteristics. Using simulations from the Coupled Model Intercomparison Project Phase 6 and observation from Berkeley Earth Surface Temperature, this study reveals an unusually weak signal of summer SAT change in NC since the 1960s. This uniquely weak signal can be attributed to the small net contribution of external forcings, mainly from anthropogenic greenhouse gases (GHG) and aerosols (AA). Compared to other land regions in the same latitudinal band, the GHG‐induced warming was weaker and AA‐induced cooling was stronger in NC, resulting in the weakest SAT change signal and thus the lowest signal‐to‐noise ratio. This weaker GHG‐induced warming plays a more important role in the SAT change difference between NC and other land regions in the same latitudinal zone. Under different emission scenarios in the future, the signal‐to‐noise ratio in NC will become as large as those in the other land regions in the same latitudinal band and the northern hemisphere, which is partly due to the smaller relative differences in the SAT change signal between NC and the other two regions. The projections of SAT change indicate that climate change in NC will probably become more violent and vulnerable.