bluuebunny/crossref_metadata_2025 huggingface dataset:
Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer
Authors: Sabit Hussein , Nazir Shaimaa , Abdel-Ghany Shimaa , A. Said Osama , W. Mohammed Eman , M. Badawy Omnia , L-zayyat Ashraf , I. Alqosaibi Amany , Cevik Emre , Tombuloglu Huseyin , Elzawahri Mokhtar
Published: August 2019

Being the most common cause of female deaths worldwide, breast cancer (BC) is intensively studied over the last two decades. In the present investigation, we evaluated the promoter methylation of three cancer-related genes; PARP-1, p21, and Rb in 10 bi-matched BC samples (ductal carcinoma and lobular carcinoma) included the core tumor and the adjacent normal tissue. H&E-stained histopathological sectioning revealed grade 2 and grade 3 tumor cells. Methylation-specific PCR (MSP) was performed using methylated (M) and unmethylated (U) primers for the three genes understudy. Histone acetyltransferase was measured in tumor and healthy tissues. A variation in the methylation state of the promoter region of the three genes were observed in core tumor and healthy tissue. PARP and Rb were hypermethylated in tumor tissues while p21 was partially methylated. HAT activities were positively correlated with the methylation pattern observed in healthy tissues, as HAT was highly expressed in healthy vs. tumor tissues. The obtained data might indicate that patients might be at risk of BC recurrence after being subjected to mastectomy. These data could be employed as a core in epigenetic-based data mining to establish a model for predicting the breast cancer-predisposed patients. However, further investigations are needed to fulfill this goal.
Association of rs61803665 Polymorphism in the F11R Gene with Increased Risk of Gastric Cancer
Authors: Khalili Zahra , Moghanibashi Mehdi , Ghaderi Abbas
Published: August 2019

Introduction and Objectives: Gastric cancer is one of the most common cancers throughout the world and it is classified as a multifactorial disease. F11R is one of the genes whose role in different cancers is proven. As miR-335-5p and miR-638 are involved in the control of F11R gene expression, and rs61803665 in the F11R gene is located at the binding site to this miRs, we investigated the possible association of this polymorphism with the risk of gastric cancer. Materials and Methods: 189 gastric cancer patients and 190 healthy individuals were enrolled in this case-control study. Genomic DNA was extracted from blood samples of the patient and the control groups. Using PCR-RLFP technique, the genotype of all samples for rs61803665 in the F11R gene was determined. The results were analyzed statistically using logistic regression and Chi-square tests. Results: The frequency of genotype AA, AG and GG in the control group were 27.90%, 40.52%, and 31.58%, respectively. The frequency of genotype AA, AG and GG in the patient groups were 24.34%, 30.68%, and 44.98%, respectively. The frequency of allele A and allele G in the control group were 48.15% and 51.85%, respectively. Besides, the frequency of allele A and allele G in the patient groups were 39.68% and 60.32%, respectively. Based on the results of statistical tests, there is a significant correlation between the risk of gastric cancer and genotype GG (P = 0.008, OR = 1.771, % 95CI=1.164-2.693) and allele G (P = 0/019, OR = 1/412, 95% CI = 1/059-1/883).Conclusion: This study showed that there is an association between allele G at the rs61803665 in the F11R gene and the increased risk of gastric cancer.
Chrysin Sensitizes Human Lung Cancer Cells to Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL) Mediated Apoptosis
Authors: Mehdi Syed Hassan , Zafaryab Md , Nafees Sana , Khan Asad , Ahmad Irfan , Hafeez Zubair Bin , Rizvi Moshahid Alam
Published: August 2019

Background: Lung cancer is the primary cause of cancer deaths worldwide. Thus, the requisite for more coherent methods to lung cancer therapy is needed. Purpose: Chrysin (5, 7-dihydroxyflavone) is a naturally occurring flavonoid having a wide range of pharmacological properties and is commonly found in fruits, vegetables, honey and propolis. In our study, we have hypothesized that chrysin would have anticancer activity on L132 lung cancer cell line.Methods: The cytotoxic effects were assessed by MTT and NRU assay. DAPI was used to evaluate the cell death. The pro- or anti-apoptotic proteins were detected by Western Blot assay, and, besides, mRNA expression was analysed with RT-PCR. In silico study of chrysin was performed to identify suitable inhibitors against the protein function. Results: Results indicated that chrysin enhanced the inhibitory effects of TRAIL (Tumour Necrosis Factor Related Apoptosis-Inducing Ligand) in comparison to TNF-α (tumour necrosis factor) on cell viability in L132 lung cancer cells and altered nuclear morphology of cells was observed in DAPI (4’,6-diamidino-2-phenylindole) staining after 48 hrs treatment. Treatment with chrysin enhances TRAIL-induced apoptosis by increasing the expression of apoptosis-related proteins including caspase-3, 8, 9 and Bax, whereas the expression of Bcl-2 was decreased. Chrysin was docked with caspase-3, 8, 9, Bax, and Bcl-2 proteins to identify suitable inhibitors against the protein function.Conclusion: We concluded that chrysin sensitizes lung cancer cells to TRAIL-induced apoptosis and may be considered for future studies as a promising therapeutic candidate for human lung cancer.
The Efficacy of Licorice Root (Glycyrrhiza glabra) and Yarrow (Achillea millefolium) in Preventing Radiation Dermatitis in Patients with Breast Cancer: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Authors: Malekzadeh Mona , Sandoughdaran Saleh , Homayi Shandiz Fatemeh , Honary Soheyla
Published: August 2019

Background: Radiation dermatitis is one of the most common side effects of radiotherapy for breast cancer, affecting approximately 85 percent of patients. The aim of this study is to assess the effect of Licorice root (Glycyrrhizin glabra) and Yarrow (Achillea millefolium) on preventing radiotherapy-induced dermatitis in breast cancer patients.Methods: Seventy-five patients with breast cancer who had undergone mastectomy and were planned to receive radiotherapy (RT) were enrolled in this randomized, double-blind, placebo-controlled study. The extract of Achillea millefolium and Glycyrrhizin glabra root were incorporated into a vanishing cream base. Patients were randomly divided into three groups and received Glycyrrhizin glabra cream, placebo or Achillea millefolium cream for five weeks during RT. The rate and grade of radiation dermatitis were recorded at baseline, at the end of third week and at the end of treatment using a modified Radiation Therapy Oncology Group (RTOG) grading tool.Results: At the end of the third week, the group receiving Achillea millefolium cream showed milder skin complications than other groups. At the end of treatment, rate of skin complications in groups receiving herbal drugs was lower than placebo group but it was not statistically significant. Conclusions: In conclusion, the results of this study did not present a significant difference between Glycyrrhiza glabra, Achillea millefolium and placebo on preventing radiation dermatitis.
A Retrospective and Epidemiological Survey of Patients with Esophagus Cancer in Ilam City During a 10 Years Period
Authors: Zarei Hamed , Tavan Hamed
Published: August 2019

Background: esophagus cancer is the sixth deadly cancer among other types with high rate of death which has made it one of the common cancers. Based on what mentioned, this retrospective study was designed to assess the tumor incidence rate in a 10 years period in Ilam city.Materials and methods: this is a retrospective study during 1385 till 1394 in Ilam city. Our source of patients was the afflicted patients. The sample size and the statistical society of research were determined based on census. The research materials included of two types first included the demographic information of patients (age, gender, tumor type, level of education, residency, smoking and lipid profile) and the second part was some information about the esophagus cancer (anatomical site, pathologic findings and lipid profile).using SPSS version 19, the data was analyzed. Results: the statistical society included 150 individuals afflicted with esophagus cancer in which the most prevalent age group was men older than 70 years (31.3%). In terms of anatomical site, the middle third of esophagus had 75 cases (50%), the last third had 45 cases (30%) and the first third had 30 (20%) individuals. Furthermore, as time went on, the number of new cases increased. Conclusion: the risk factors for occurring the cancer were the age group greater than 70 years, being male, lower educational situation, unemployment, living in an urban areas, smoking, hereditary, hyperlipidemia (LDL, TG, CHOL) and finding tumor in middle third of esophagus (because of existing helicobacter pylori virus and impropriate diet). Being able to identify endangered people, one could begin treating patients and thereby, saving time, cost and increasing the rate of survivors.
Impact of Monthly 120 Mg Denosumab on Bone Metabolism in Bone-metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy
Authors: Miyakawa Jimpei , Taguchi Satoru , Suzuki Motofumi , Endo Kaori , Nose Yorito , Sato Toshikazu , Ishikawa Akira , Fukuhara Hiroshi , Homma Yukio
Published: August 2019

Background: While semiannual 60 mg denosumab is a common treatment for osteoporosis, impact of monthly 120 mg denosumab, the common treatment protocol for bone metastases from solid tumors, on bone metabolism is unclear.Materials and Methods: We reviewed 15 patients with bone-metastatic prostate cancer who initiated monthly 120 mg denosumab in conjunction with androgen deprivation therapy between 2013 and 2014. Bone mineral density (BMD) was measured at lumbar spine and femoral neck using dual energy X-ray absorptiometry (DXA), before treatment and annually thereafter. Bone metabolism markers, including urine N-terminal telopeptide (uNTx) and bone type alkaline phosphatase (BAP), were monitored monthly.Results: Twelve of 15 (80%) patients had evaluable DXA before treatment, and of them, eight underwent DXA after a year of initiation without discontinuation of denosumab. Percent changes in BMD from baseline were +6.2% at lumbar spine and +7.6% at femoral neck, both of which were significant increases (both P<0.01). Bone metabolism markers were evaluable in 11 (73%) patients: uNTx decreased rapidly, while BAP declined gradually after initiating denosumab. These effects were similar to those seen by the standardized dose for osteoporosis in previous literature. There were no denosumab-related severe adverse events during the follow-up period. Conclusions: The impact of monthly 120 mg denosumab on bone metabolism was significant, but almost equivalent to that of the standard dose for osteoporosis (60mg semiannually) in bone-metastatic prostate cancer undergoing androgen deprivation therapy. Whereas the higher dose has reportedly reduced skeleton-related events, the effect on bone metabolism seemed plateaued or showed no dose-dependency.
Relationship with lung carcinoma in the patients with Anthracosis by detection of expression of P16 and MUC1 genes.
Authors: Ghashghaee Mona , Bahrami Naghmeh , Naji Tahereh , Mohamadnia Abdolreza
Published: August 2019

Introduction and objective: Anthracosis is a pneumoconiosis caused by coal dust. The term “pneumoconiosis” refers to an occupational lung disease caused by long-term inhalation of dust. To achieve more efficient diagnosis and treatment methods, changes in the expression of MUC1 and P16 genes in the patients with anthracosis and their relationship with none-small cells lung carcinoma were examined.

Methodology: Thirty anthracosis samples (center of lesion) and thirty healthy samples (edges of lesion) were collected from anthracosis patients diagnosed by a specialist. The patients signed a written letter of consent beforehand. The expression of MUC1 and P19 biomarkers was measured through Real-Time PCR. The relationship of the expression of biomarkers with tumor staging and lung carcinoma stage was examined.

Results: The two groups in the study were compared using t-test. P16 marker was positive at the center and edges of lesions in seven (out of 30) and 18 (out of 30) cases respectively. There was a significant difference between positive P16 markers at the center and edges of the lesions (p-value<0.001). MUC1 marker was positive at the center of lesions in 21 cases out of 30 (sensitivity = 70%) and it was positive at the edges of lesions in seven cases out of 30. In terms

lesions (p-value<0.001).

Conclusion: The results indicated a relationship between anthracosis and lung carcinoma. Clearly, the positive cases of P16 genes at the edges of lesions were higher than that at the center; while, the positive cases of MCU1 gene at the center of lesions were higher than that at the edges. Further studies with larger sample groups are needed to provide more evidences.
Surveying the Expression of CDH1 and EGFR Genes in Patients with Anthracosis and Its Relationship with Lung Carcinoma
Authors: Izadian Zahra , Bahrami Naghmeh , Naji Tahereh , Mohamadnia Abdolreza
Published: August 2019

Introduction: Anthracosis is known as the black lung disease and studies have shown relationships between the disease and lung carcinoma. In addition, the expression of CDH1 and EGFR genes can be used as the prognostic of anthracosis. The present study surveys the expression of CDH1 and EGFR genes in anthracosis patients and its relationship with non-small cells lung carcinoma. Methodology: Thirty anthracosis patients diagnosed by a specialist participated in the study. The subjects were asked to sign an informed letter of consent and then, to examine the expression of CDH1 and EGFR genes through real-time PCR, tissue samples were collected. Afterward, the relationship of expression of the biomarkers with tumor staging and cancer progress was examined. Results: Mean age of the patients was 48±10.5 years. As the reference gene, 18sRNA was adopted and comparison of mean CTs at the center and edges of lesions showed no significant difference. As to CDH1 gene at the center of lesions, 12 cases out of 30 were positive, which indicates 40% sensitivity; while at the edges, 20 cases out 30 were positive. Comparison of the positive rates of CDH1 gene at the center and edges of the lesions indicated a significant difference (P-value<0.001). Moreover and with regard to EGFR gene at the center of lesions, 19 cases out 30 were positive (sensitivity = 63.3%) and five cases out of 30 were positive at the edges of lesions (control). There was also a significant difference between the positive cases of EGFR gene at the center and edges of the lesions (P-value<0.001). Clearly, the positive cases of CDH1 at the edges were higher than that at the center, while in the case of EGFR gene, positive cases at the center were higher than that at the edges. It is notable that to obtan results with higher accuracy entails increasing the sensitivity level. Following similar studies and to have higher accuracy, the experiments were carried out with three iterations. Conclusion: In general, the results indicated a sort of relationship between anthracosis and lung carcinoma. To prove such relationship on a more solid ground, more studies with larger number of subjects are needed.
Current Status of Pediatric Oncology in Iran
Authors: Alebouyeh Mardawig
Published: August 2019

The pediatric hematology and oncology (PHO) services in Iran have steadily improved during the past 10 years.Today, we have specialized PHO services in almost all major cities throughout the country, where 43 board-certified or eligible pediatric hematologist-oncologists are currently giving care to children suffering from cancer or hematological disorders. In this paper, the state of Pediatric hematology-oncology in Iran will be presented.
Attitude and Barriers of Community Pharmacists towards Cancer Health Promotion: A Systematic Review
Authors: Mensah Kofi Boamah , Oosthuizen Frasia , Bemah Bonsu Adwoa
Published: August 2019

Health promotion promotes quality of life and shows several positive outcomes for cancer patients and survivors. Studies indicate a decrease in mortality rates among women with breast cancer, improvement in the emotional state and quality of life among lung cancer patients. Community pharmacists are advocating, facilitating and providing cancer-related health promotions. This systematic review analyses attitude and barriers of community pharmacist towards cancer health promotion. Searches of major bibliographic databases identified primary studies published in English from 2005 to July 2017. A total of 323 records were identified and 5 were considered as been eligible based on the inclusion standard. Findings from the eligible studies revealed a favorable attitude of community pharmacists towards cancer health promotion but have perceived barriers towards it. The review was limited to five studies, hence regional or country studies will have to be carried out for an in-depth analysis of the attitude and barriers of community pharmacists and ways to address it.
Risk Factor of Deep Vein Thrombosis in Gynecologic Cancer Patients at Rajavithi Hospital
Authors: Pookcharoen Nawapas , Insin Putsarat , Asavapiriyanon Suvanna
Published: August 2019

Background: Venous thromboembolism (VTE), that includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), represents a significant complication after major pelvic surgery and potentially lethal disease in gynecologic cancer patients. However, its incidence and associated risk factors have not been well established.Objectives: To evaluate risk factors that may be associated with deep vein thrombosis (DVT) in gynecologic cancer patients.Materials and Methods: This retrospective case-control study included patients who diagnosed as gynecologic cancer with or without DVT between January 2002 and December 2016 at Rajavithi Hospital. The presence of DVT was confirmed by either color doppler ultrasonography or computed tomography scan. Patient's demographic data, type and stage of cancer, including treatment modalities were compared. Univariate analysis and multivariate logistic regression analysis were analyzed to calculate odds ratios (OR) and determine independent risk factors for DVT.Results: Over 14 years periods, 242 patients with DVT were identified in a total 8476 gynecologic cancer patients. The incidence of DVT was 2.85% in this patient setting. Complete data were available in 468 patients, 156 (33.3%) cases with DVT diagnosed were compared with 312 (66.7%) controls without DVT. Among patients with DVT, the median time to DVT diagnosis was 4 months (IQR 2-12 months) after diagnosis of cancer, most of cases (89.5%) were symptomatic DVT, and a half of them (49%) were detected in ovarian cancer. In a multivariate analysis, 3 significant predictors of developing DVT were identified: advanced-stage cancer (OR 7.22; 95%CI 4.62-11.28, p<0.001), patient undergoing lymphadenectomy (OR 1.90; 95%CI 1.21-2.98, p=0.005), and patient with massive operative blood loss (≥1500 ml; OR 2.09; 95%CI 1.12-3.91, p=0.021).Conclusions: Awareness of DVT is the best way to prevent the venous thromboembolism. Therefore, an appropriate prophylaxis and closed monitoring of gynecologic cancer patients with advanced-stage cancer, undergoing lymphadenectomy, and massive operative blood loss should be mandatory to against thromboembolism complications.
Oral Sub Mucous Fibrosis: Exploring Therapeutic Strategies Using -anti TGF β Drugs
Authors: Sheshaprasad Ranganath , Pai Anuradha
Published: August 2019

Objective: Oral submucous fibrosis (OSMF) is a chronic irreversible potentially malignant condition causing morbidity. Transforming Growth Factor beta (TGF-β1) plays the central role in its development. Hence early intervention is the key to limit the progress of the disease. The aim of this paper was to review the effective therapeutic agents available to neutralize the pathological effect of TGF-β1 in OSMF. Methods: An electronic search was conducted and we reviewed the records of the https://clinicaltrials.gov/, the registry of clinical trials that have been conducted internationally and in the United States in order to look for drugs associated with different types of fibrotic disorder. The studies related to pulmonary fibrosis were also included. We performed another search in the PubMed database and chose the successfully tested drugs as the result of our previous search and used the keywords "Name of the selected drug" "TGF" "Fibrosis." Results: A total of 89 studies were listed in the search and finally, 9 studies were considered for the analysis. The search results indicated the potential benefit of two drugs namely nintedanib and pirfenidone. It was noted that nintedanib reversed TGF-β1-induced EMT in non-small cell lung cancer cells and pirfenidone treatment inhibited TGF-β1-induced up-regulation of phosphorylation of ERK1/2, p38 and Jun amino-terminal kinases (JNK) in a renal fibrosis rat model. Conclusion: It was concluded that pirfenidone and nintedanib were found to have a promising role in the treatment of pulmonary fibrosis also linked to the pathological effect of TGF-β pathway. Therefore, we put forward the suggestion of designing preclinical studies, as well as clinical trials to test the effectiveness of these drugs in treating oral submucous fibrosis.
Clinical Findings and Demography of Retinoblastoma in a Tertiary Hospital in a Remote Area in a Developing Country
Authors: Asina Miranda Golda , Simanjuntak Gilbert W S
Published: August 2019

Purpose: To report clinical characteristics and demography of retinoblastoma managed in a tertiary eye hospital in a remote area in a developing country.Methods: This is a descriptive retrospective study. Clinical characteristics were gender, age, tumor growth, onset, severity, laterality, nutritional status, and prominent clinical signs. The socioeconomic demographics of the patient’s families were grouped into work and economic conditions, and education. Management and its outcome were recorded.Results: There were 91 samples, distributed evenly in five years. The frequency was even between middle income 45 patients (49.5%) and lower middle income 46 patients (50.5%). The mean age at diagnosis was 3-5 year with 49 patients (53,8%), ranging from 1 to 12 years. Male to female ratio was 1:1. Less nutritional status were 64 patients (70.3%). All cases occurred unilaterally without family history of RB, and laterality was equal between right and left eye, with 1:1 ratio. Those patients who mainly presented with extra ocular involvement numbered 73 patients (80.2%) and those with clinical symptoms of protruded numbered 70 patients (76.9%). Patients generally presented in stage IV of 70 cases (76.9%). The mean onset was 1-2 years in 43 cases (47.2%). The therapeutic management was chemotherapy. After treatment, all patients followed up in two weeks.Conclusion: RB patients referred to a tertiary hospitalin a remote area are more likely to come in advanced stage, from middle-income group parents. More extraocular cases seen with major clinical features of protruded eye with an onset of 2-3 years.
Multiple Primary Cancers in North Tunisia, 2000 - 2009
Authors: Ben Ayoub Wided , Ben Khadhra Hajer , Khiari Hyem , Ben Abdallah Mansour , Boussen Hamouda , Hsairi Mohamed
Published: August 2019

Background and Objective: To evaluate and report the frequency, epidemiologic and anatomic - clinical features of patients who developed MPM from the data of North Tunisia Cancer Registry, during the period 2000-2009.Materials and methods: From a population of 53757 new patients of the North Tunisia National Cancer Registry database presenting new cases of cancers during the period 2000-2009 in North Tunisia, we collected and analyzed those with MPMTs. We used for MPMT the international IARC diagnosis criteria are published in ICD-O Third Edition. Results: In the 53757 new cancer cases registered from 2000-2009, we collected 528 cases (1.0%) of MPM. Mean age at diagnosis of the 1st cancer was 61 years (22-99) and sex-ratio at 1.08 (275M/253F) while mean age at the 2nd cancer diagnosis was 62 years(29 to 99). Among the 528 cases, the most frequent 1 st cancer site was breast in females (147 pts, 58.1%) and urinary tract for males (56 patients, 20.4%). In the 528 MPM cases, 321 (60.8%) were synchronous and 207 cases (39.2%) were metachronous tumors. The median time from 1 st to 2 nd cancer was 1.98 months (range 0-140). The most associated 1 st -2 nd cancer sites were breast in 110 patients (43.3%) in females and for males' urinary tract -prostate cancers (45 patients, 16.3%). Conclusions: The coexistence of a synchronous or metachronous MPM is possible and have to be considered during pretreatment evaluation. A close follow-up should be recommended to detect second malignancies in patients treated for a 1 st cancer.
Predictive Factors of Histological Response after Preoperative Concomitant Radiochemotherapy in Middle and Low Rectal Cancer
Authors: Ouabdelmoumen Asmae , Sbai Ali , Elmejjatti Fouad , Bourhaleb Zohour , Abda Naima , Mezouar Loubna
Published: August 2019

Objective: The aim of our study was to identify potential predictive factors beyond pathologic response after neoadjuvant radiochemotherapy.Patients and Methods: Between January 2009 and December 2014, 40 patients with rectal carcinoma were included in the study. The treatment consisted of radiation ranging between 39 and 50.4 Gy associated with a concomitant chemotherapy with capecitabine. The correlation between histological response (complete response and downstaging) and potential predictive factors were investigated.Results: Complete response was 15% (06 patients), tumor regression of 32.5% (13 patients), and the absence of tumor response of 52.5% (21 patients). In univariate analysis, the circumferential extension of the tumor was significantly associated with tumor downstaging (p = 0.007) and complete tumor response (p = 0.001). However, the delay between the RCT and the surgery was a significant predictor for downstaging (p = 0.02).Conclusion: the parietal circumferential extension was a potential predictor of pathologic complete response (PCR) and downstaging after neoadjuvant chemoradiation. The time between the radiochemotherapy and the surgery was a significant predictor for downstaging. Delaying surgery beyond 8 weeks seems to result in the highest probability of PCR.
Survival Outcomes in Male Breast Cancer – A Single Institution Experience
Authors: Hariharan Nisha
Published: August 2019

Introduction: Male breast cancer is an uncommon entity. Due to the scarce numbers, treatment protocolshave largely been extrapolated from available evidence for female breast cancers.Methods: We analysed the clinicopathological features and survival outcomes for male breast cancer patients treated at our institute between January 2010 and June 2016.Results: Of the 5534 women treated at our institute, we screened 40 male breast cancers of whom 33 had available follow up data and were included in the present analysis. Male breast cancer constituted 0.7% of all breast cancers. The median age was 60 years and the median tumor size was 3cm with 66% of patients having nodal disease at presentation. Invasive ductal carcinoma was the most common histology and 97% were hormone receptor positive. Most of the patients (87.8%) underwent an upfront modified radical mastectomy. With a median follow up of 36 months, 10 patients experienced recurrences all of which were distant metastasis (3 to the bone, 1 to the brain, and 6 had visceral metastasis). Of these, 7 patients succumbed to the disease. The 3-year overall survival was 78.7 %.Conclusion: Male breast cancer is a rare clinical entity and current treatment guidelines follow those for women. Due to the lack of awareness, men often present to clinics at an advanced stage. Social support targeted at improving awareness and access to treatment could improve outcomes in this cohort.
Thyroid Dysfunction in Type 1 Diabetes Mellitus in an Iranian Elderly Woman
Authors: Nemati Mohadese , Roshani Asl Elmira , Haghshenas Venus , Rashidi Siamak , Ahmadi Zohre , Taushih Bohran
Published: August 2019

Objective: Type 1 Diabetes mellitus (T1DM) and thyroid dysfunction consider as main metabolic and endocrine disorders. In previous studies, individuals with T1DM were susceptible to Thyroid disorders. The prevalence of clinical and subclinical Thyroid dysfunction have noticeable importance especially regarding women and their related stigma. Methods: The presented survey, a case-control study evaluated the thyroid dysfunction among T1DM elderly women referred to diabetes clinic of Tohid Hospital in Sanandaj city. The whole blood samples were attained from all individuals and then the following tests were done: fasting blood-sugar (FBS), Serum TSH, anti-Thyroperoxidase (Anti-TPO) and Free T4.Results: The prevalence of Thyroid disorder in examined patients was 17 percent and autoimmune Thyroid dysfunction disorder, that examined by positive test-result of Anti-TPO showed up in 10.2 percent of patients. Prevalence of sub-clinical Hypothyroidism was 13.2 percent; the clinical Hypothyroidism were 7.3 percent. Based on our data 2.9 percent of T1DM have subclinical Hyperthyroidism and 1.4 percent have clinical Hyperthyroidism. In our study, increased TSH level and existence of Anti-TPO in TIDM patients might be regarded as an additional TIDM problem in studied disease.Conclusion: This study confirmed the association between autoimmune Thyroid dysfunction (based on positive Serum-test of Anti-TPO) and T1DM.
Hope and Life Engagement of Cancer Patıents at the Advanced Stage
Authors: Nural Nesrin , Çıracı Yaşar Yasemin , Gülhan Güner Seçil
Published: August 2019

Introduction: Cancer is a clinical tableau in which many complicated physical and psychological problems are encountered and the individual’s defense mechanism against the process is often shaken. With the deterioration of the prognosis and the progression of the disease, individuals whose belief in healing is reduced may lose their life engagement and hope.Objective: The purpose of this cross-sectional and descriptive study is to determine the level of hope and life engagement of individuals with advanced stage cancer.Methods: The study was conducted with 74 advanced cancer patients who were hospitalized in the oncology, palliative care and surgery clinics of the Trabzon Kanuni Training and Research Hospital, fulfilled the research criteria and signed informed consent forms out of their free will. The data were collected using the “Demographic Information Form,” which included subjective questions, the “Integrative Hope Scale” consisting of four subscales, and the “Life Engagement Scale” in which the level of life engagement was detected. The data were analyzed by using the SPSS program and “ANOVA,” “Independent t-test” and “Correlation test” were used to analyze the relationship between the hope and life engagement scores and variables. The value p<.05 was accepted as statistically significant.Results: The common hope level mean of the patients included in the study was 104.5±6.8 and the common life engagement mean was 23.9±4.9. Correlating the significant differences in the subscales of the scale, the variables affecting the level of hope were determined as “ living place, fear of death, and despair,” and the variables affecting life engagement were determined as “education status, living place, ruefulness, and needing psychological support.”Conclusions: The psychosocial support and solidarity that the individual receives from other individuals in his environment and health care providers positively affects his selfconfidence, hope and life engagement. On the other hand, contrary to the meaning of “I am not afraid of dying,” this statement can be considered an expression of giving up on life. Nurses should focus on the messages underlying what the patients say.
Knowledge and Awareness of Breast Self-Examination among Secondary School Girls in Seremban, Negeri Sembilan
Authors: Che Mut Nur Anis Izzati , Abu Bakar Noor Hidayah , Kamal Izdihar , Abdullah Suhaimi Siti Aisyah , Mawaddah Mohammad Nurul , Ahmad Rosmah , Mohd Zain Norhayati
Published: August 2019

Objective: Breast Self-Examination (BSE) is an early detection method of breast cancer. It is able to develop responsibility for breast health among women to always aware of any changes in the breast. Thus, secondary school girls age is the perfect age to start practice the BSE. The purpose of this study is to determine the level of knowledge and awareness on BSE among secondary school girls in Seremban, Negeri Sembilan. Methods: A cross-sectional study was conducted among 502 secondary school girls using self-administered questionnaire covering socio-demographic data, knowledge and awareness of breast cancer and knowledge and awareness of BSE. Results: The mean age of the participants is 14.9 ± 0.06 years. The majority of the participants were Malays (86.5%). A total of 6.1% of the participants had a family history of breast cancer. Nine percent of participants had a good knowledge and 91.0% had poor knowledge regarding BSE. There is a significant difference between the age of participants with the level of knowledge and awareness (p = 0.014). Conclusion: The knowledge and awareness of BSE were poor among secondary school girls in Seremban, Negeri Sembilan.
Efficacy of Extracorporeal Irradiation in Primary Malignant Bone Tumours: A Tertiary Cancer Centre Experience
Authors: K Gunaseelan , Patro Dilip Kumar , Lal Arun , P Kannan , D Biswajit , N Vijayaprabhu
Published: August 2019

Background: Limb-sparing approaches involving a combination of surgery, chemotherapy, and radiotherapy are preferred in primary malignant bone tumours whenever possible. The limb function can be maintained by performing reconstruction either using a prosthesis or bone graft. Extracorporeal irradiation is a novel and exciting technique in which the restoration is done using the patient’s own tumour bone. In this article, we present the local control, complications, and functional outcome of 49 cases of primary malignant bone tumours treated using the technique of extracorporeal irradiation. Materials and methods: 49 patients with primary malignant bone tumours were treated with extracorporeal irradiation between the year 2007 to 2015.En-bloc resection of the tumour and the involved bone along with soft tissues was performed about four weeks after the completion of three to four cycles of neoadjuvant chemotherapy. The bone segment was irradiated with 6MV linear accelerator to a dose of 50Gy. After extracorporeal irradiation, the bone was re-implanted using fixation devices. Local control, relapse-free survival, complications and functional outcome were studied. Results: Out of 49 patients, there were 33 males and 16 females. The median age was 19 years. Femur and tibia were the most common tumour locations with osteosarcoma being the most common histology (74%). The local control rate was 94%. The 8 year local recurrence-free survival and distant metastasis-free survival were 89% and 84% respectively. The overall complication rate was 20%. Infection was the most frequent complication, observed in 46% of the patients who developed complications. Out of 49 patients, 40 had reported a good range of movements. Conclusion: Extracorporeal irradiation and re-implantation is a convenient alternative to prosthesis from a health economics point of view, provided severe complications are managed and avoided so that functional results can be achieved.
The Premature Mortality Cost of Cancers Attributable to Secondhand Smoking in Indonesia
Authors: Kristina Susi Ari , Ayu Linda Permitasari Ni Putu , Ahsan Abdillah
Published: August 2019

Objectives: Many studies reported that secondhand smoke associated with many health problems including multiple types of cancer. Both secondhand smoking and cancer have a significant economic impact on society, especially in developing countries. To assess this economic burden, we estimated the costs of lost productivity due to premature mortality cancer attributable to secondhand smoking in Indonesia.Methods: This study used to estimating the number of premature mortality cost (PMC) of six cancers (lung, bladder, colorectal, stomach, pancreas and larynx) due to secondhand smoking in Indonesia. This research was using descriptive epidemiological prevalence-based research design, with cancers mortality data gained from Indonesian National Health Insurance (NHI) database in 2016. Results: Burden priorities for Indonesian men and women accounted for IDR 1,075 trillion by lung cancer, IDR 667 trillion by colorectal cancer and IDR 336 trillion by pancreas cancer out of total PMC IDR 2,665 trillion. We also calculated present value for total PMC which was IDR 2,512 trillion after discounted by 3%. The higher premature mortality cost in males than females reflects higher wages and rates of workforce participation.Conclusion: Lost productivity costs due to cancers related to secondhand smoking premature mortality were significant source of high economic burden in Indonesia. The result of this study may provide an alternative perspective on the cancer burden on society and to strengthen tobacco and smoke free control policy decisions.
Discordance of Histo-pathological Diagnosis of Patients with Soft Tissue Sarcoma Referred to Tertiary Care Center
Authors: Rastogi Sameer , Aggarwal Aditi , Shishak Sorun , Barwad Adarsh , Dhamija Ekta , Pandey Rambha , Mridha Asit Ranjan , Kumar Venkatesan Sampath , Khan Shah Alam , S.V. Deo7 Suryanarayana , Sharma Mehar Chand
Published: August 2019

Background: Reaching the correct histo-pathological diagnosis of soft tissue sarcomas (STS) is a great challenge and is cornerstone for treatment planning. Need of expertise for diagnosis is limited due to the lack of dedicated expert sarcoma pathologists and oncologists in India. In this study we highlight the pattern of pathological diagnosis and its accuracy outside specialist centre. Methods: We performed retrospective analysis of all patients referred to us with a clinical or histopathologic diagnosis of STS over the period January 2016 to December 2017. According to the protocol, all patients had a review of histopathology diagnosis from our institute. The tissue blocks if available were reviewed and a fresh biopsy was performed when required. The histopathologic diagnosis was also reviewed in the joint clinic, giving clinico-radiological inputs to sarcoma pathologists. For the patients with outside diagnosis and discordant report, we divided them into major discrepancy (including change of diagnosis of sarcoma to benign or other histological entity that could potentially change the treatment plan) or minor discrepancy (like mild change in grade or histopathological diagnosis not affecting the treatment plan). Statistical analysis was done by SPSS ver 23.Results: There were 149 patients with median age of 36 years (range 14-77 years), and 93 patients (62.4%) were males. About 57% (85 cases) of patients had localized disease. Most common subtypes were synovial sarcoma (16%), liposarcoma (9%), soft tissue ewings sarcoma (9%), MPNST (9%), leiomyosarcoma (8%), and undifferentiated pleomorphic sarcoma (8%). Of 149 patients, 47 (31.5%) had not been worked up outside by immunohistochemistry or other molecular studies and thus comparison was not possible; while 4 patients couldn’t retrieve blocks and repeat biopsy could not be performed. Of 97 patients (biopsy = 84, FNAC = 13) who had diagnosis from outside, 37% had major discrepancy and 24% had minor discrepancy as compared with our diagnosis from the sarcoma specialists. Univariate analysis revealed that the major discrepancy was more in non-extremity than extremity STS (p = 0.003).Conclusion: Histopathologic diagnosis in more than half of patients referred from outside centers was discordant with respect to the diagnosis of our centre with major implications on 37% of cases. We believe this is due to the lack of sarcoma pathology experts, and they are virtually non-existent in the multidisciplinary clinic set up outside the tertiary care centres.
LAYANAN KELOMPOK UNTUK MENGURANGI PERILAKU SISWA YANG MELANGGAR TATA TERTIB SEKOLAH DI SMP NEGERI 17 BANJARMASIN
Authors: Yasan Raymoel , Farial Farial , Auliah Nurul
Published: August 2019

Student behavior that violates school rules is the behavior of students who are not responsible for carrying out their duties as students. The purpose of this study was to determine whether there was a reduction in the behavior of students who violated the school rules using group counseling for students of SMP Negeri 17 Banjarmasin. This study uses quantitative methods. This type of research is pre-experimental designs with Onegroup design, pretest-posttest design.Based on the results of the Wilcoxon test data calculation, the Z table obtained for the sig value 0.27 so Zhitung is -2.207, because this value is absolute so that the negative sign is not taken into account. So that the calculated Z value becomes 2.207, then the calculated Z value is compared with the Z table value with a significance level of 6%, the price of Z table = 0. Then Z count = 2.207>Ztable = 0 then Ha is accepted thus the behavior of the violation of the rules there is a change after being given group counseling services seen from the provisions of Zhitung>Ztable and Ho refused. So it can be concluded that group counseling services can reduce the behavior of students who violate the school rules for students who have a very high category to be high in class IX C students in SMP Negeri 17 Banjarmasin.
PENERAPAN APLIKASI REKAM MEDIS PASIEN POLIKLINIK RUMAH SAKIT GIGI MULUT GUSTI HASAN AMAN ( RSGM ) BANJARMASIN
Authors: Muin Agus Alim
Published: August 2019

Kemajuan teknologi jaringan komputer merupakan salah satu pendukung pengolahan data dan informasi yang telah menjadi kebutuhan pokok. Perusahaan industri dan jasa serta semua sektor ekonomi yang ada saat ini telah memanfaatkan jaringan komputer sebagai alat penunjang pengolahan data dan sistem informasi perusahaan. Penelitian ini memberikan solusi bagi permasalahan pada Rumah Sakit Gigi Mulut Gusti Hasan Aman (RSGM) Banjarmasin sebagai salah satu bidang kesehatan yang membutuhkan penggunaan komputer sebagai sarana pengolahan data, sarana penyajian informasi, serta sarana kegiatan. Semua ini dapat dipecahkan dengan menerapkan suatu program aplikasi yang dapat mengintegrasikan semua data pada Rumah Sakit Gigi Mulut Gusti Hasan Aman (RSGM) Banjarmasin dalam satu basis data. Aplikasi yang dibuat bekerja dengan menggunakan php dan mysql sehingga mempermudah pemakai dalam pengolahan data. Dengan menggunakan aplikasi tersebut diharapkan dapat meminimalisir permasalahan-permasalahan pada Rumah Sakit Gigi Mulut Gusti Hasan Aman (RSGM) Banjarmasin seperti penginputan data bermasalah ataupun hilang.Dari permasalahan tersebut memunculkan gagasan untuk membuat sebuah aplikasi yang dapat mempermudah administrasi pelayanan dalam mengisi data pasien baik dalam hal pelayanan dan juga dapat membantu para pegawai mudah mengolah data dan melihat data. Aplikasi ini dikembangankan dengan menggunakan Sublime Text, Xampp dan MySQL sebagai database. Keyword: Administrasi,Aplikasi,Rekam Medik,Web
PROTOYPE APLIKASI DATA SUMBER DAYA MANUSIA(SDM) UNTUK PENYEDIA LAYANAN JASA ASISTEN RUMAH TANGGA DI BANJARMASIN
Authors: Alfah Rina
Published: August 2019

Untuk membantu mempermudah Penyedia layanan jasa Baby Sitter dalam mendata para calon BS (Baby Sitter ) dan ART (Asisten Rumah Tangga) maka perlu adanya sebuah sistem Komputer pada tempat tersebut. Untuk itu maka kami merancang sebuah aplikasi dengan menggunakan pemrograman power builder dan mysql ,sebuah aplikasi Data SDM Untuk penyedia layanan jasa Baby sitter dan asisten rumah tangga. Dengan ada nya aplikasi ini diharapkan jika ada permasalahan dari baby sitter ataupun asisten rumah tangga dengan orang yang memakai jasa mereka ,misalnya kasus kekerasan pada anak atau pencurian dirumah mereka , maka penyedia jasa bisa langsung mencari data lengkap personal yang bersangkutan dengan cepat. Selain itu aplikasi ini mencakup data pribadi/personal (curriculum vitae), penilaian kerja , dan data transaksi penggajihan untuk BS dan ART setiap bulannya. Keywords: Aplikasi, Baby Sitter, MySQL, Power Builder, Transaksi
SISTEM INFORMASI KEARSIPAN ONLINE PADA PT. TOWER BERSAMA GROUP ( TBG ) BANJARMASIN
Authors: Ibrahim Ibrahim , Rahman Auliya
Published: August 2019

Sistem Informasi merupakan suatu komponen yang sangat penting dalam kehidupan masyarakat saat ini. Dengan memanfaatkan internet, informasi tidak lagi menjadi suatu hal yang sulit untuk disampaikan. Perkembangan internet sangat berguna bagi organisasi, sekolah, perguruan tinggi, perusahaan swasta, dan instansi pemerintahan di Indonesia sebagai media yang tepat untuk mengimplementasikan sistem informasi. Dengan perkembangan teknologi saat ini PT. Tower Bersama Group memerlukan Sistem Informasi kearsipan online ini  merupakan suatu aplikasi yang berguna membantu proses penyimpanan dan pencarian data kegiatan yang dilakukan oleh setiap karyawan. Pencatatan online ini bisa meningkatkan  secara efektif pencatatan dan sistem informasi kegiatan guna kecepatan dalam memperoleh informasin yang diinginkan. Aplikasi ini dibuat dengan mengaplikasikan Visual Basic 6.0 untuk menghasilkan sistem informasi data kegiatan. Untuk pembuatan sistem informasi ini menggunakan bahasa pemograman PHP dan database MySQL.  Kata Kunci: Pencatatan Online, Visual Basic,sistem informasi,arsip
PENERAPAN ALGORITMA DECISION TREE C4.5 UNTUK KLASIFIKASI PENENTUAN DAFTAR PRIORITAS PENGEMBANGAN JEMBATAN
Authors: Karyadiputra Erfan , Hijriana Nadiya
Published: August 2019

Data Mining merupakan proses mengidentifikasi data dan informasi yang bertujuan untuk membantu mendapatkan informasi yang bermanfaat dan meningkatkan pengetahuan penggunanya. Kelancaran distribusi barang maupun jasa sangat dipengaruhi oleh kondisi infrastruktur jalan maupun jembatan yang menghubungkan beberapa wilayah-wilayah yang secara administrasi merupakan bagian dari Provinsi Kalimantan Selatan. Kondisi jembatan yang rusak tentu dapat menghambat pendistribusian barang maupun jasa sehingga perbaikan maupun pemeliharaan perlu terus dilakukan. Dalam penentuan prioritas pengembangan jembatan agar menghindari adanya tumpang tindih (overlaping) suatu kegiatan dalam satu lokasi, ataupun lokasi yang sama sekali belum tertangani dengan baik, maka dibutuhkan perencanaan pengolahan data dan informasi yang terintegrasi, sehingga data dan informasi perencanaan yang diperoleh tersebut dapat dijamin keakuratan datanya. Banyaknya ruas jembatan yang tersebar di Provinsi Kalimantan Selatan dan terbatasnya anggaran perbaikan ataupun pemeliharaan sehingga instansi terkait perlu menentukan daftar prioritas jembatan yang diprioritaskan untuk disetujui dan dilakukan perbaikan maupun pemeliharaan. Salah satu teknik yang dapat diterapkan untuk mengklasifikasi daftar prioritas pengembangan jembatan yaitu dengan menerapkan metode klasifikasi data mining menggunakan algoritma C4.5. Penerapan metode data mining menggunakan algoritma C4.5 menghasilkan performance akurasi sebesar 82.84% dengan nilai AUC sebesar 0,825 sehingga termasuk dalam kategori good clssification.Keywords : Algoritma C4.5, Data Mining, Klasifikasi