bluuebunny/crossref_metadata_2025 huggingface dataset:
Целенаправленный синтез ингибиторов главной (Mpro) и папаино-подобной (PLpro) протеаз SARS-CoV-2 на основе скаффолда 2,4-диметил-5-фенил-1H-пиримидин-6-она
Authors: Рожкова А. С. , Кодониди И. П. , Аненко Д. С. , Кирик С. Д. , Поздняков Д. И. , Филиппова Валерия Петровна , Вдовенко-Мартынова Н. Н.
Published: August 2023

Обосновано использование скаффолда 5-фенил-1H-пиримидин-6-она для поиска биологически активных соединений, обладающих противовирусной активностью, основой которого является ядро пиримидин-4-она, присутствующее в эндогенных веществах и лекарственных препаратах. Осуществлен прогноз молекулярной активности и фармакокинетических дескрипторов in silico для стирилпроизводных N-незамещенного 5-фенил-1H-пиримидин-6-она посредством веб-сервиса SwissADME. Отсутствие данных кристаллографии и представления о таутомерной форме 2,4-диметил-5-фенил-1H-пиримидин-6-она потребовало измерение и анализ рентгенограммы исходного вещества для объяснения реакционной способности в реакции стирилирования. Синтезированы новые производные 5-фенил-2-[(E)-стирил]-1H-пиримидин-6-она, и изучена их ингибирующая активность в отношении главной (Mpro) SARS-Cov-2 и папаино-подобной (PLpro) протеаз SARS-Cov-2, что позволило предположить наличие у них противовирусной активности.
Синтез и антидепрессивная активность 5-аминозамещенных 3-бром-1-(1,1-диоксотиетан-3-ил)-4-нитро-1H-пиразолов
Authors: Клен Елена Эдмундовна , Никитина Ирина Леонидовна , Халиуллин Феркат Адельзянович , Шепилова Светлана Олеговна , Никитина Екатерина Андреевна , Гайсина Гульнара Галиевна , Уразбаев Максат Азатович , Самородов Александр Владимирович , Павлов Валентин Николаевич
Published: August 2023

5-Аминозамещенные 3-бром-1-(1,1-диоксотиетан-3-ил)-4-нитро-1H-пиразолы синтезированы реакциями 3,5-дибром-1-(1,1-диоксотиетан-3-ил)-4-нитро-1H-пиразола с алифатическими, ароматическими и гетероциклическими аминами. Структура синтезированных соединений подтверждена с помощью ИК-, 1H и 13C ЯМР-спектроскопии и масс-спектрометрии. По расчетам in silico для них прогнозируется отсутствие токсических рисков (мутагенности, онкогенности, репродуктивной токсичности, местно-раздражающего действия), низкая токсичность (IV – V класс) и приемлемая пероральная биодоступность (исходя из показателя площади топологической полярной поверхности). Все синтезированные соединения, независимо от строения амина, проявляли значимую антидепрессивную активность при однократном внутрибрюшинном введении мышам-самцам в тесте принудительного плавания, сравнимую с амитриптилином, при этом 1-[3-бром-1-(1,1-диоксотиетан-3-ил)-4-нитро-1H-пиразол-5-ил]-4-метилпиперазин (соединение IIi) оказывало значимый седативный эффект в тесте открытого поля. Результаты комплексной оценки биологической активности синтезированных соединений in vivo/in silico свидетельствуют о перспективности класса производных 5-аминозамещенных пиразолов для дальнейших исследований.
Противогрибковая активность серебряных солей пирроло[3,4-c]пиразол-3-онов и пиразол-3-карбоксамидов, содержащих сульфамидную группу
Authors: Новикова Валентина Васильевна , Бобровская Ольга Васильевна , Гейн Владимир Леонидович
Published: August 2023

Изучена противогрибковая активность 10 новых соединений ряда серебряных солей пирроло[3,4-c]пиразол-3-онов и пиразол-3-карбоксамидов, содержащих в своём составе сульфамидную группу. Сопоставлены данные исследований in vitro и компьютерного прогнозирования биологической активности веществ. Выявлены фармакофорные группы, влияющие на антифунгальную активность. Установлено, что соединение с 4-этоксифенильным заместителем в 5 положении гетероцикла проявляет наиболее выраженный противогрибковый эффект (МПК50 = 1,0 мг/л, МПК90 = 15,6 мг/л), превышая активность препаратов сравнения в 2 и более раз, в том числе против видов Candida non-albicans, что дает основания для дальнейшего изучения механизмов выявленной антимикотической активности.
Биодеградируемые микрочастицы с инкапсулированным противовоспалительным пептидом инграмон
Authors: Мармий Н. В. , Арефьева Т. И. , Есипов Дмитрий Станиславович , Ташлицкий В. Н. , Кожокарь У. С. , Овчинников М. В. , Радюхина Н. В. , Сидорова М. В.
Published: August 2023

В статье описана методика инкапсулирования противовоспалительного додекапептида инграмон в микросферы биоразлагаемого сополимера молочной и гликолевой кислот (ПЛГА), обеспечивающая пролонгированное высвобождение данного пептида за срок до 28 дней. Методика позволяет достигать эффективности инкапсуляции свыше 90 % и пригодна для получения инъекционной суспензии, удовлетворяющей требованиям Государственной фармакопеи РФ. Охарактеризованы распределение пептида внутри полученных микросфер, профиль его высвобождения. Обнаружена тенденция к подавлению JE/CCL2-зависимой миграции моноцитов у мышей с предварительным (за 7 дней до эксперимента) введением инграмона-депо.
On the Occurrence of Rhabdophis leonardi (Wall, 1923) in Vietnam and Laos, with Preliminary Comments on the Taxonomy and Distribution of the Complex of Rhabdophis nuchalis (Squamata: Serpentes: Natricidae)
Authors: Nguyen Tan Van , David Patrick
Published: August 2023

The species Rhabdophis leonardi (Wall, 1923) is recorded for the first time from Vietnam (Lao Cai Province) based on the re-examination of specimens deposited in the collections of the Muséum National d’Histoire Naturelle (Paris) which were formerly identified as Rhabdophis nuchalis. Furthermore, we also re-evaluate the taxonomy and distribution of species of the complex Rhabdophis nuchalis group and we provide an updated identification key to species of this complex.
Found but Forgotten: On the Records, Misidentification, and Potential Rediscovery of the Rare Bromo Tengger Semeru Mountain Endemic Snake (Serpentes: Colubridae: Tetralepis fruhstorferi)
Authors: Septiadi Luhur , Idrus Meilinda Rodhiya , Arroyyan Ahmad Nauval , Fathoni Muhammad , Erfanda Muhammad Prayogi , Devi Sandra Rafika , Hanifa Berry Fakhry , Priambodo Bagus , Sidik Irvan , Kurniawan Nia
Published: August 2023

Tetralepis fruhstorferi is a snake currently only known to be endemic to a single active volcano complex of Bromo Tengger Semeru National Park in East Java of Indonesia. Its taxonomic identity and natural history are poorly known, as the most recent collection was in 1978 and limited to only a few collection records. We investigated two recently published surveys that have misidentified this species. This may indicate that T. fruhstorferi is still present in its type locality and our future surveys would focus on finding this species to assess its taxonomy and population status.
Anteseden dan Konsekuensi dari Consumer Brand Engagement
Authors: Dwiputri Anindya Priyatningtias , Dwiputri Anindya Priyatningtias , Riorini Sri Vandayuli
Published: August 2023

Penelitian ini memiliki tujuan untuk menganalisis pengaruh Entertainment, Customisation, Interaction, Electronic Word of Mouth (EWOM), dan Trendiness, terhadap Consumer Brand Engagement dan Consumer Brand Engagement terhadap Brand Image.  Sebanyak 360 responden dikumpulkan dengan menyebarkan kuesioner secara online. Perangkat lunak Structural Equation Model (SEM) dan AMOS 24 digunakan sebagai teknik analisis data. Purposive sampling adalah pendekatan yang diterapkan. Hasil penelitian ini menunjukkan bahwa Entertainment berpengaruh terhadap Consumer Brand engagement, Customisation berpengaruh terhadap Consumer Brand Engagement, Interaction berpengaruh terhadap Consumer Brand Engagement, Electronic Word of Mouth (EWOM) berpengaruh terhadap Consumer Brand Engagement, Trendiness berpengaruh terhadap Consumer Brand Engagementt, Consumer Brand Engagement berpengaruh terhadap Brand Image.
Pengaruh Green Marketing dan Service Quality Terhadap Customer Loyalty dengan Customer Satisfaction Sebagai Moderasi Pada Kedai Kopi
Authors: Santika Arya Wira , Wijayanti Jessica , Sugiarto Kevin , Pakpahan Arnolt Kristian
Published: August 2023

Pelnellitian ini melngkaji karaktelristik, pelrselpsi, dan kelpuasan pellanggan Starbucks Coffelel di Jakarta dalam lingkup manajelmeln sosial. Studi ini melnggunakan pelndelkatan analisis delskriptif untuk melnyellidiki variabell yang telrkait delngan pelmasaran hijau, kualitas layanan, kelpuasan pellanggan, dan loyalitas. Kuelsionelr digunakan untuk melngumpulkan data, yang kelmudian dianalisis mellalui distribusi frelkuelnsi dan pelrhitungan pelrselntasel. Telmuan ini melmbelrikan wawasan belrharga telntang delmografi, pelndidikan, pelkelrjaan, dan distribusi usia relspondeln. Sellain itu, pelnellitian ini melngelksplorasi pelrspelktif pellanggan telntang pelmasaran ramah lingkungan, kualitas layanan, kelpuasan pellanggan, dan loyalitas telrhadap Starbucks Coffelel. Hasilnya melngungkapkan sikap positif telrhadap produk belrlabell ramah lingkungan, pelringkat tinggi untuk kualitas layanan, dan kelpuasan kelselluruhan delngan pelngalaman Starbucks Coffelel. Wawasan ini dapat melmandu Starbucks Coffelel dalam melningkatkan stratelgi pelmasaran, melmbina loyalitas pellanggan, dan melningkatkan kelpuasan pellanggan.
The Effect Of Educational Inequality On Economic Growth In Indonesia
Authors: Liyana Nur Farida
Published: August 2023

Education is the elevator of the Indonesian economy. Where education is able to improve the welfare of society. However, the development of education in Indonesia is not evenly distributed. This inequality can be felt both between villages and cities as well as between regions in Indonesia. In theory, the occurrence of educational inequality will increase the poverty rate which will have an impact on decreasing economic growth. So in this study we want to examine the effect of educational inequality on economic growth by taking into account other variables, namely the poverty rate, population and government spending on education. The data used is secondary data from 34 provinces in Indonesia from 2015 to 2020 sourced from the Central Bureau of Statistics and the Directorate General of Fiscal Balance, Ministry of Finance. The results obtained are true that education inequality exists in Indonesia, even though the scale is still relatively low to medium. However, statistically it is found that educational inequality has a significant negative effect on economic growth. In contrast to the educational inequality,  poverty rate, population and government spending on education have a positive effect, although not significant.
The Tax Policy of the Republic of Crimea: Reducing Subsidization of the Region
Authors:   Minister of Finance of the Republic of Crimea, Simferopol, Russian Federation, Kiviko I. V. , Malis N. I. ,   Financial University under the Government of the Russian Federation, Moscow, Russian Federation
Published: August 2023

Currently, the Republic of Crimea is a subsidized region, and for objective reasons the level of subsidization will not be significantly reduced in the near future, as a result of which the implementation of the indicators reflected in the Law of the Republic of Crimea "On the Strategy of Socio-economic Development of the Republic of Crimea until 2030" does not seem realistic. At the same time, the tax policy of the republic is developing measures to increase its own budget revenues, and they are already giving their positive results. Undoubtedly, the expansion of the revenue side of the regional budget should be based on increasing the manageability of the tax potential, which is formed taking into account the indicators of the dynamics of economic development. The unique geographical, resource and climatic conditions of the Republic of Crimea allow for a widely diversified economic development policy and, accordingly, regional tax policy. Based on the peculiarities of the territorial location and a large number of health resort and recreational complexes, it is possible to form a program of short-term measures to increase the tax base under special tax regimes, personal income tax and other taxes due to the cascade effect of business activity of individuals and SMEs. Full or partial solution of the problem of seasonality of active use of tourist infrastructure will increase the tax potential and, in turn, reduce subsidized dependence on the federal center. The management of tax potential should certainly be based on the analysis of the level of tax burden due to the fact that excessive tax burden can lead to the effect of reverse increase in tax payments.
ScholarOne - THE IMPORTANCE OF DEFENSE DIPLOMACY FOR ARMED CONFLICT RESOLUTION
Authors: Stankov Vassil
Published: August 2023

This paper highlights the importance of defense diplomacy as a peaceful and non-violent instrument for crisis prevention and armed conflict resolution, which is crucial for easing military-political tensions and reducing confrontation. Furthermore, the main functions of defense diplomacy are revealed, and their importance in efforts to de-escalate military-political tensions is explained. This paper explores the role of defense diplomacy activities in conflict prevention and resolution, with a main emphasis on strategic engagement. Then, crisis and conflict prevention are analyzed as part of noncombat military operations conducted to engage the parties involved in the effort to prevent, contain, or terminate a conflict and reconcile belligerent parties. This paper suggests some basic defense diplomacy features and presents a case study of defense diplomacy between Russia and Turkey. Finally, this article concludes that defense diplomacy can be a powerful tool for conducting peaceful, non-violent, and non-coercive operations for crisis prevention and conflict resolution.
On the concepts of the history of the St. Petersburg formalists (by B. Eikhenbaum and Yu. Tynyanov)
Authors: Ke Peng
Published: August 2023

This article examines the history concepts of the St. Petersburg branch of Russianformalism. Thefocus is on the concept of history in theoretical and artistic works by B.M. Eikhenbaum and Yu.N. Tynianov.
Exploring the aesthetic ideas in original culture-taking on the example of Dunhuang frescoe
Authors: Wang Xiujun
Published: August 2023

Dunhuang murals are a type of primitive culture. The article analyzes the unique forms of expression of Dunhuang frescoes.
Research on the interaction among government, media and the public under the background of public emergencies: historical aspects
Authors: Yang Wu
Published: August 2023

The article probes into the history of the interactive relationship among government, media and public under the background of public emergencies, and establishes and improves the benign interactive mechanism among government, media and public. The interactive development trend of policy media and public agenda in public emergencies is also discussed.
Enhancing Satellite Imagery Through Novel Color Space Fusion and Innovative Learning Approach
Authors: Ozcan Samed
Published: August 2023

As the demand for comprehensive geographical information continues to soar, satellite imagery emerges as a critical asset for acquiring essential geospatial data. However, inherent challenges within satellite images, including diminished clarity, subdued contrast, and color irregularities arising from diverse atmospheric and imaging conditions, impede the extraction of vital information. Despite the strides taken in deep learning and its capacity to decipher intricate patterns, existing research grapples with issues such as the erosion of localized features and unwarranted color amplification. In response to these challenges, this study pioneers an innovative avenue to enhance satellite imagery. This is achieved through the fusion of distinctive color spaces and an inventive learning approach, harnessing the potential of the CMYK and HSV color models. The CMYK color space facilitates meticulous color calibration and the alleviation of artifacts, whereas the HSV color space enriches color vividness and intricate textural details. By enlisting an inventive learning technique involving diverse sample sets, the proposed methodology aspires to yield images that closely emulate premium-grade satellite imagery, transcending the conventional traits of unprocessed satellite images. Through a rigorous battery of experiments conducted on real-world satellite image datasets, the proposed approach convincingly demonstrates its prowess. It not only attains remarkable benchmarks in critical metrics such as PSNR, SSIM, and UIQM but also surpasses alternative modalities in the realm of satellite image enhancement
PHLDA2 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that pleckstrin homology-like domain family A member 2, encoded by PHLDA2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PHLDA2 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of PHLDA2 in primary tumors was correlated with patient overall, distant metastasis-free and recurrence-free survival. Modulation of PHLDA2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
INSTRUMEN ANALISIS PENELITIAN TERKAIT FORELEARN APPERCEPTION
Authors: Rokhmawan Tristan , Fitriyah Lailatul
Published: August 2023

Dalam bagian ini, penelitian akan menguraikan berbagai temuan yang telah ditemukan dalam penelitian terdahulu yang berkaitan dengan konsep "Forelearn Apperception". Hal ini mencakup cara-cara di mana konsep tersebut diterapkan dalam konteks pembelajaran, dampaknya terhadap pemahaman awal, dan hubungannya dengan prestasi belajar. Hasil-hasil ini akan dijelaskan secara deskriptif, memberikan gambaran menyeluruh tentang kontribusi penelitian-penelitian sebelumnya terhadap pemahaman kita tentang "Forelearn Apperception".
Psychometric Evaluation of The Exercise-related Cognitive Errors Questionnaire (E-CEQ) Among Chinese Emerging Adults
Authors: Cao Qin , kuang jin , Ye Xiaomin , Wang Ting , Herold Fabian , Taylor Alyx , Ng Jonathan Leo , Hossain Md Mahbub , Kramer Arthur F. , Schinke Robert , Zou Liye
Published: August 2023

Objective: Cognitive errors involve negatively biased thinking. When it happens in the exercise domain, it is considered as exercise-related cognitive error. The purpose of this study is to validate the Chinese version of the Exercise-related Cognitive Errors Questionnaire (E-CEQ-C) among Chinese emerging adults, a self-report measure to evaluate cognitive errors of context-relevant information related to exercise. Method: following a forward-backward translation of the E-CEQ’s 24 initial vignettes, the E-CEQ-C and the Chinese version of the Cognitive Distortions Questionnaire (CD-Quest-C) for gathering evidence of criterion-related validity were administrated among a sample of Chinese emerging adults (N= 376, 29.0% male) through an online survey. After a two-week interval, 105 out of 376 participants attended the re-test of the E-CEQ-C. Project analysis, confirmatory factor analysis (CFA), internal consistency and test–retest reliability, and concurrent validity were then completed.Results: Results from the CFA analysis support the 24-item, six-factor structure among Chinese emerging adults (χ2=699.038, RMSEA=0.073, CFI=0.919, TLI=0.904, and SRMR=0.055). Cronbach’s α of the six dimensions of the E-CEQ-C were all above 0.7. The test-retest reliability coefficients of each subscale and total scale were acceptable, ranging from 0.60 to 0.81. In accordance with the literature, we also observed positive associations between the six dimensions of E-CEQ-C and the constructs of the CD-Quest-C, which provided concurrent validity evidence for the E-CEQ-C.Conclusion: This study has demonstrated that E-CEQ-C proved to be a psychometrically sound measure for use.
dAn-oNo: Learning Environment for Data Journalists Teaching Data Analytics Principles
Authors: Stoiber Christina , Emrich Štefan , Radkohl Sonja , Goldgruber Eva , Aigner Wolfgang
Published: August 2023

Several journalistic abilities are required to derive narratives from data, including the skill to discover and construct compelling stories (data storytelling), employ data-driven techniques to research and analyze information (data literacy), utilize visualization methods effectively (visualization literacy), and approach data with a combination of creativity and critical thinking. Despite their expertise in journalism, journalists often encounter challenges in comprehending and utilizing novel visual representations or understanding data analysis methods. The main objective of the dAn-oNo learning environment is to guide journalists through the data analytics process by removing coding hurdles and allowing them to experiment with and understand the code. The learning environment utilizes a Jupyter notebook with Markdown sections. It incorporates a step-by-step approach, covering various stages of the data analytics workflow, such as data importing, inspection, statistical analysis, and in-depth analysis. The learning environment also includes an automated profiler that translates warnings and information into human-understandable insights. The design and implementation of the dAn-oNo learning environment were informed by a literature review, user research, interviews with Austrian data journalists, a phase of exploring different technical possibilities for the learning environment, and rapid prototyping. We also report on the results of a preliminary study with students. The prototype is accessible here: https://github.com/stemrich/SEVA_DA-Onboarding-Tool
TIGD5 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that tigger transposable element-derived 5, encoded by TIGD5, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TIGD5 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of TIGD5 in primary tumors was correlated with patient distant metastasis-free survival. We recently reported differential expression of TIGD2 in metastasis to the brain in patients with breast cancer (6). Modulation of TIGD2 and TIGD5 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
SIX2 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that SIX homeobox 2, encoded by SIX2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. SIX2 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of SIX2 in primary tumors was correlated with patient distant metastasis-free survival. Modulation of SIX2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ASUHAN KEPERAWATAN PADA Ny I DENGAN DIAGNOSA KEPERAWATAN NYERI AKUT DALAM TINJAUAN TEORI KATHARINA COLCABA DI RUANGAN TERATAI RSUD UNDATA PALU
Authors: bura hesky
Published: August 2023

POLITEKNIK KESEHATAN KEMENKES PALUJURUSAN KEPERAWATAN PRODI PENDIDIKAN PROFESI NERS Bura Hesky, 2023 Asuhan Keperawatan Pada Ny I Dengan Diagnosa Keperawatan Nyeri Akut Dalam Tinjauan Teori Katharina Colcaba Di Ruangan Teratai Rsud Undata Palu, Karya Ilmia Akhir Ners. Poltekkes Kesehatan Kemenkes Palu, Prodi Pendidikan Profesi Ners. Pembimbing (1) Fajrillah Kolomboy Pembimbing (2) AmirABSTRAKxiv + 102 Halaman + 10 Tabel + 4 Gambar + 2 lampiranFraktur dibagi atas fraktur terbuka dan fraktur tertutup. Fraktur terbuka merupakan suatu fraktur dimana terjadi hubungan dengan lingkungan luar melalui kulit. Fraktur tertutup dimana kulit tidak tertembus oleh frakmen tulang, sehingga tempat fraktur tidak tercemar oleh lingkungan diluar kulit.Tujuan penelitian ini adalah untuk melaksanakan asuhan keperawatan pada Ny I dengan diagnosa diagnose keperawatan nyeri akut di tinjau dari teori kenyamanan Katharina Colcaba Di Ruangn Teratai RSUD Undata Palu. Studi kasus ini menggunakan metode pendekatan proses keperawatan. Data di kumpulkan dengan menggunakan format pengkajian, pemeriksaan fisik, observasi, pemeriksaan penunjang. Penelitian ini dilaksanakan selama 3 hari di ruangan teratei RSUD Undata PaluDari hasil pengkajian di temukan digagnosa keperawatan yang di tegakkan menurut SDKI ada 3 dengan diagnose yaitu nyeri akut, resiko infeksi, gangguan mobilitas fisik diagnose utama pada kasus ini nyeri akut. intervensi menggunakan SLKI manajemen nyeri dengan menggunakan teknik masase untuk mengurangi nyeri. Hasil evaluasi menunjukan setalah di lakukan Tindakan keperawatan selama 3 hari dengan Teknik masase untuk memberikan rasa nyaman kepada pasin Kesimpulan setelah di lakukan asuhan keperawatan dengan tindakan mandiri keperawatan menggunakan Teknik masase untuk mengurangi rasa nyeri pada pasien post operasi fraktur cruris dari skala nyeri 8 ke nyei skala 6
Design of Visualization Onboarding Concepts for a 2D Scatterplot in a Biomedical Visual Analytics Tool
Authors: Stoiber Christina , Moitzi Daniela , Stitz Holger , Girardi Dominic , Streit Marc , Aigner Wolfgang
Published: August 2023

Biomedical research is highly data-driven. Domain experts need to learn how to interpret complex data visualizations to gain insights. They often need help interpreting data visualizations as they are not part of their training. Integrating visualization onboarding concepts into visual analytics (VA) tools can support users in interpreting, reading, and extracting information from visual presentations. In this paper, we present the design of the onboarding concept for an interactive VA tool to analyze large-scale biological data, particularly high-throughput screening (HTS) data. We evaluated our onboarding design by conducting a cognitive walkthrough and interviews with thinking aloud. We also collected data on domain experts’ visualization literacy. The results of the cognitive walkthrough showed that domain experts positively commented on the onboarding design and proposed adjusting smaller aspects. The interviews showed that domain experts are well-trained in interpreting basic visualizations (e.g., scatterplot, bar chart, line chart). However, they need support correctly interpreting the data visualized in the scatterplot, as they are new to them. Another important insight was fitting the onboarding messages into the domain’s language.
Control of HTR7 by NOD2.
Authors: Mamoor Shahan
Published: August 2023

We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate control of 5-hydroxytryptamine (serotonin) receptor 7 (HTR7) expression by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
Within-Person Changes in Aversive Reactivity Predict Session-to-Session Reductions in Anxiety and Depression in the Unified Protocol
Authors: Semcho Stephen , Southward Matthew W. , Stumpp Nicole , Smith Michelle , Fruhbauerova Martina , Sauer-Zavala Shannon
Published: August 2023

The Unified Protocol (UP) theoretically leads to reductions in emotional disorder symptoms by reducing aversive reactions to emotions. However, aversive reactions can take many forms (e.g., non-acceptance, behavioral avoidance). We examined if (1) multiple aspects of aversive reactivity predicted session-to-session changes in anxiety and depression in the UP, (2) these aspects reflected a single latent construct, and (3) changes in this latent construct predicted changes in anxiety and depression. Participants (N = 70, Mage = 33.74, 67.1% female, 74.3% white) completed six sessions of UP modules and measures of aversive reactivity, anxiety, and depression before each session. We used hierarchical linear modeling and random-intercept cross-lagged panel models to test aspects of aversive reactivity and a latent factor of aversive reactivity, respectively, as predictors of session-to-session changes in anxiety and depression. Within-person improvements in four of five aspects of aversive reactivity predicted decreases in anxiety, and improvements in two aspects predicted decreases in depression. However, within-person improvements in latent aversive reactivity predicted decreases in anxiety at five sessions and in depression across all sessions. These results add to the growing literature highlighting the role of aversive reactivity as a potential transdiagnostic process involved in improvements in emotional disorder symptoms during treatment.
Habilidades blandas y técnicas en evaluaciones de estudiantes a docentes - Soft and Hard Skills in Students' Evaluation of Teachers
Authors: Manchini Nigel , Jiménez Óliver , Ramos Natalia
Published: August 2023

Resumen Mediante el análisis de calificaciones y comentarios a docentes (n = 3665) en la plataforma MisProfesores.com, se abordó la importancia asignada por el estudiantado a las “habilidades blandas” o Soft Skills (SS) y “habilidades técnicas” o Hard Skills (HS), contrastando hipótesis pre-registradas y realizando exploraciones cualitativas. Se utilizaron técnicas de análisis textual para cuantificar las referencias a SS y HS, analizando su relación con la calificación y explorando el vocabulario usado para evaluar a docentes excelentes. Los resultados sugieren que el lenguaje de los comentarios está significativamente relacionado con la calificación, y que las referencias a SS predicen mejor la calificación que las referencias a HS. Los análisis cualitativos sugieren que, aunque las SS son especialmente salientes a la hora de evaluar a un/a docente como excelente, las HS no son ignoradas sino presupuestas. Palabras clave: actitudes del profesor, evaluación del profesor, análisis de textos, habilidades sociales, conocimiento profesional. Abstract Through the analysis of numeric evaluation and comments to teachers (n = 3665) on the platform MisProfesores.com, the importance assigned by students to Soft Skills (SS) and Hard Skills (HS) was assesed, contrasting pre-registered hypotheses and performing qualitative explorations. Textual analysis techniques were used to quantify the references to SS and HS in comments, analyzing their relationship with the numeric evaluation and exploring the vocabulary used to evaluate excellent teachers. The results suggest that comment language is significantly related to numeric evaluation, and that references to SS are better at predicting it than references to HS. Qualitative analyzes suggest that, although the SS are especially salient when evaluating a teacher as excellent, the HS are not ignored but presupposed. Keywords: teacher attitudes, teacher evaluation, text analysis, social skills, professional knowledge.
Do reminders of God increase willingness to take risks?
Authors: White Cindel , Dean Chloe , Laurin Kristin
Published: August 2023

Many people, and American Christians in particular, view God as a benevolent protector. Those who believe in God may therefore expect that they can safely engage in potentially risky activities, secure in the knowledge that God will look out for their best interests and ensure good outcomes. Initial experiments supported this hypothesis, but recent attempts to replicate them failed. This unreliable pattern may reflect a false conceptual hypothesis, or an inadequate method: Both the initial reports and the replication attempts used outdated religious priming methods we now know to be ineffective. The present research aimed to clarify the relationship between thinking about God and risk-taking behaviors. A pilot study (N = 264) showed that American Christians do expect that God will protect them during risky activities; moreover, those who hold this expectation more strongly report greater willingness to take risks. This registered report then used a high-powered preregistered experiment to test whether having participants explicitly think about God’s (presumably protective) influence over what happens in their lives increases their willingness to take risks. Results confirmed that American Christian participants were more willing to take non-moral risks when thinking about God, compared to a control condition, d = 0.28, 95% CI [0.12, 0.44], p < .001. This pattern was robust to different exclusion criteria and was consistent across domains of career, recreational, and social risks. By using the most recent and sensitive methods, this study provides a more definitive test of the conceptual hypothesis that thinking about God can influence risk-taking.
Intrinsic functional connectivity in medial temporal lobe networks is associated with susceptibility to misinformation
Authors: Ratzan Alexander Samuel , Siegel Matthew D. D. , Karanian Jessica M , Thomas Ayanna K , Race Elizabeth
Published: August 2023

Memory is notoriously fallible and susceptible to misinformation. Yet little is known about the underlying cognitive and neural mechanisms that render individuals vulnerable to this type of false memory. The current experiments take an individual differences approach to examine whether susceptibility to misinformation reflects stable underlying factors related to memory retrieval. In Study 1, we report for the first time the existence of substantial individual variability in susceptibility to misinformation in the context of repeated memory retrieval, when the misinformation effect is most pronounced. This variability was not related to an individual’s tendency to adopt an episodic retrieval style during remembering (trait mnemonics). In Study 2, we next examined whether susceptibility to misinformation is related to intrinsic functional connectivity in medial temporal lobe (MTL) networks known to coordinate memory reactivation during event retrieval. Stronger resting-state functional connectivity between the MTL and cortical areas associated with visual memory reactivation (occipital cortex) was associated with better protection from misinformation. Together, these results reveal that while memory distortion is a universal property of our reconstructive memory system, susceptibility to misinformation varies at the individual level and may depend on one’s ability to reactivate perceptual details during memory retrieval.
Implicit Bias Measurement with Finger Tracking: Going Beyond Reaction Time to Assess IAT Preferences
Authors: Woodford Benjamin S.
Published: August 2023

The Implicit Association Test is a widely used tool for measuring unconscious biases. However, traditional Implicit Association Test designs do not provide detailed information about the cognitive processes involved in decision-making. In this study, I introduce a Finger Tracking paradigm, called a Finger Tracking Implicit Association Test, adapting the traditional block design of the Implicit Association Test to a screen-tracking tablet environment. The Finger Tracking Implicit Association Test allowed us to collect in-flight data on the cognitive processes occurring during decision-making. Results suggest that the traditional D-score results used in Implicit Association Test literature can be enhanced by the inclusion of curvature, complexity, and temporal trajectory data collected through Finger Tracking adapted implicit association tests. These in-flight metrics offer rich evidence of cognitive preference that is independent of D-score calculations, called d-scores when calculated for multiple metrics. Finally, a spatio-temporal analysis of trajectory data gives a nuanced look at the time scale bias present in flight during sorting stimuli. The approach gives a visually appealing way to assess bias independent of D-score methodology by assessing decision development. Findings suggest that a Finger Tracking Implicit Association Test is a valuable addition to the implicit cognition toolkit, providing insight into the cognitive processes involved in decision-making and providing discriminant power above that of traditional reaction time-based tests like the Implicit Association Test.
'As if the Soul Returns to the Body': Affect, Stuckedness, and (In)Voluntary Return to Nicaragua from Spain
Authors: Hjalmarson Elise
Published: August 2023

Building on recent literature which challenges the basis for participation in voluntary return programmes as founded on free, voluntary, and individual decisions, this article contends that, for some, the act of ‘choosing’ to return generates a profound emotional response. In the case of a Nicaraguan migrant woman explored in detail here, the execution of said return activates feelings of relief, euphoria, and hope, as well as a renewed sense of self: it is as if her soul returns to her body. Nevertheless, her response is temporally and contextually contingent, as returning to Nicaragua via AVRR does not necessarily diminish her desire to remigrate or render her less ‘stuck’. The empirical material which informs this paper was collected through digital ethnography and in-person encounters in both Spain and Nicaragua between 2020 and 2021.
Responsi Penilaian Harian 01 “Matematika” Kelas 5ABCD
Authors: Setiawan Adib Rifqi
Published: August 2023

Responsi Penilaian Harian 01 “Matematika” Kelas 5ABCD
Penilaian Harian 01 “Ilmu Pengetahuan Alam” Kelas 5D
Authors: Setiawan Adib Rifqi
Published: August 2023

Penilaian Harian 01 “Ilmu Pengetahuan Alam” Kelas 5D
“History of Music to Be Played” di Marta Salvatori
Authors: Thalia Nita
Published: August 2023

This research paper delves into the critical historical aspect of music in education and its profound significance in scholastic programs. This study focuses on the exploration of instructional methodologies in music history, highlighting the recognition of formal and artistic templates, the comprehension of “genre”, and the importance of attentive listening. The research further explores the necessity for appropriate music history textbooks and endorses an interdisciplinary approach. The primary research objective of this paper centers on the innovative idea of a “musical history to be performed”, emphasizing the active engagement with music as a vital instructional technique. This research utilizes a robust methodological framework to articulate the importance of both writing and playing music history. The study employs an experiential learning approach, emphasizing the importance of a first-hand engagement with music. The goal is to discern the impact of these immersive educational experiences on students’ learning, particularly regarding music history. By correlating theoretical insights from textbooks with the practical experience of performing historical music pieces, this study aims to shed light on the multi-dimensional learning opportunities provided by this pedagogical approach.
Application Progress of Modern Information Technology in the Teaching of Emergency and Critical Nursing
Authors: Thalia Nita
Published: August 2023

As modern information technology is getting more mature nowadays and has been fully applied in various industries, it has also been gradually used in the teaching of emergency and critical nursing, achieving remarkable effects. There are various teaching methods using modern information technology. However, the current teaching of emergency and critical nursing based on modern information technology in colleges and universities is still in the primary stage, and the traditional teaching methods cannot break through the key and difficult points in the field. The article briefly describes the application progress of new education and teaching methods using modern information technology in emergency and critical nursing, intending to provide some references for the teaching innovation of the course.
Delineation of source magnetization and subsurface discontinuity of Ririwai Ring Complex along Kano, North Western Nigeria
Authors:   Department of Physics, Federal University of Agriculture, Zuru, Nigeria., Mukhtar M. , Usman A. ,   Department of Physics, Kebbi State University of Science and Technology Aliero, Kebbi State Nigeria., Jeba M.A. ,   Department of Physics, Kebbi State University of Science and Technology Aliero, Kebbi State Nigeria., Lawan A.M. ,   Department of Geology, Skyline University, Nigeria.
Published: August 2023

High Resolution Aeromagnetic (HRAM) data of Ririwai (sheet 126) which lies between latitude 10° 30' to 11° 00' N and longitude 8° 30' E to 9° 00' E, was used for this research. The study area, Ririwai is situated along Kano, in the Northwestern part of Nigeria, both qualitative and quantitative interpretation techniques were employed in this study. This procedure was carefully undertaken by employing enhancement filters; vertical derivative, upward continuation, analytical signal amplitude processing, and quantitative approaches such as Euler 3D deconvolution and an apparent susceptibility filter to help further give solutions for depth estimates and magnetization. The Euler deconvolution was able to show that the solution plotted clustered around the region where the geological structures are located with average depths range of <139.8 to >904.5 m, with very few solutions having depths less than 200 m, the most prominent structure particularly the Ririwai ring complex have a depth range of 182.9 to 301.5 m. The magnetic susceptibility reading obtained shows that the area is composed of rocks high in magnetic minerals such as magnetite along the western end of the area, it is also flanked by medium to high magnetic values around the central parts with only regions of low magnetic values predominantly along the Ririwai complex and its adjoining outcrops towards the eastern half of the area under study.
PENGEMBANGAN E-LKPD BERBASIS GUIDED INQUIRY PADA MATERI KEANEKARAGAMAN HAYATI UNTUK SISWA KELAS X SMA
Authors: Wulandari Dewi Asih , L Mariani Natalina , Suzanti Fitra
Published: August 2023

E-LKPD merupakan sumber belajar versi elektronik yang dapat dibuka pada layar laptop ataupun handphone yang dapat digunakan siswa untuk mempelajari materi keanekaragaman hayati di kelas X. Tujuan dari penelitian ini adalah untuk menghasilkan E-LKPD berbasis Guided Inquiry pada materi keanekaragaman hayati untuk siswa kelas X SMA yang berkualitas. Penelitian ini dilaksanakan di Kampus Pendidikan Biologi FKIP Universitas Riau, SMAN 1 Pekanbaru, dan SMAN 8 Pekanbaru. Jenis penelitian ini adalah penelitian pengembangan dengan menggunakan model ADDIE. Pada penelitian ini hanya dilakukan hingga tahap Pengembangan. Instrumen pengumpulan data yang digunakan adalah lembar validasi dan angket respon. Pengumpulan data dilakukan dengan melakukan validasi terhadap E-LKPD yang dikembangkan, uji coba terbatas tahap I dan II. Teknik analisis data yang digunakan adalah analisis deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa hasil validasi E-LKPD pada keseluruhan aspek mendapatkan nilai rata-rata sebesar 3.69 dengan kategori sangat valid, hasil uji coba terbatas tahap I dan uji coba terbatas tahap II pada E-LKPD mendapatkan nilai rata-rata uji coba terbatas tahap I sebesar 3.74 dengan kategori sangat baik, dan nilai rata-rata uji coba terbatas tahap II sebesar 3.77 dengan kategori sangat baik. Berdasarkan hasil penelitian dapat disimpulkan bahwa E-LKPD berbasis Guided Inquiry pada materi keanekaragaman hayati untuk siswa kelas X SMA yang telah dikembangkan memiliki kualitas yang sangat baik dengan nilai kualitas sebesar 3.73.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) ELEKTRONIK PADA MATERI NARKOTIKA, PSIKOTROPIKA, DAN ZAT ADIKTIF DI KELAS XI SMA
Authors: Ramadani Ranti , Natalina Mariani , Fauziah Yuslim
Published: August 2023

Penelitian ini bertujuan untuk mengetahui kualitas E-LKPD pada materi Narkotika, Psikotropika, dan Zat Adiktif. Untuk mencapai tujuan tersebut, penelitian ini menggunakan rancangan penelitian deskriptif dengan pendekatan kuantitatif. Penelitian ini dilakukan di program studi Pendidikan Biologi FKIP Universitas Riau pada bulan Agustus 2021 – Juni 2022. Jenis penelitian yang digunakan yaitu Research and Development model ADDIE. Penelitian ini dilaksanakan hingga tahap development karena tujuan penelitian ini hanya sebatas mengembangkan suatu sumber belajar yang valid untuk digunakan dalam pembelajaran berdasarkan penilaian ahli/validator dan tanggapan responden. Instrumen yang digunakan dalam penelitian ini terdiri dari LKPD elektronik dan instrumen pengumpulan data menggunakan lembar validasi berupa angket dengan skala likert yang digunakan untuk mengetahui apakah produk yang telah dirancang valid atau tidak. Teknik analisa yang digunakan pada penelitian ini adalah teknik analisa data kuantitatif yang kemudian akan diubah menjadi data kualitatif. Data kualitatif seperti saran, kritik dari dosen ahli, maupun guru dijadikan dasar untuk perbaikan atau penyempurnaan LKPD elektronik yang akan diuji coba. Hasil validasi memperoleh nilai rata-rata 3,66 kategori sangat valid. Hasil penelitian menunjukkan bahwa bahwa E-LKPD pada materi Narkotika, Psikotropika, dan Zat Adiktif yang telah dikembangkan memiliki kualitas sangat baik ditinjau dari aspek kelayakan isi, penyajian, dan bahasa. Hal ini menunjukkan bahwa E-LKPD hasil pengembangan memiliki dapat diimplementasikan dalam proses pembelajaran pada materi Narkotika, Psikotropika, dan Zat Adiktif dikelas XI SMA