bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and Factors Associated with Symptoms of Psychological Distress among Students of Allied Health Sciences in a Nigerian University
Authors: Awotidebe Adedapo Wasiu , Adamu Garba Nasiru , Ali Tukur Muhammad , Mohammed Jibril , Lawal Isa Usman , Lawan Aliyu
Published: August 2022

Introduction: A student enrolled in Allied Health Sciences has a curriculum and academic standards that are different compared to a student enrolled in a medical programme. Nevertheless, little is known about the psychological distress of this population. Our objective was to determine whether psychological distress is prevalent in students enrolled in an Allied Health Sciences programme, as well as factors that contribute to it. Methods: Three hundred and thirty-three (333) undergraduates studying Allied Health Sciences, ages 18-30, were included in this cross-sectional study. A representative sample of students from nursing, physiotherapy, medical laboratory science, medical radiography, and optometry programmes were selected through a stratified sampling technique. A 21-item Depression Anxiety and Stress Scale (DASS-21 10) was used to collect data on psychological distress indicated by depression, anxiety, and stress. We fitted a multivariate logistic regression to identify factors associated with psychological distress among the participants. Results: As a result of the study, 58.9% reported depression, 66.1% reported anxiety, and 45.1% reported stress. Depression (AOR= 3.23; 95% CI: 1.33- 7.81), anxiety (AOR= 3.33;95% CI:1.34- 8.26) and stress (AOR= 2.58;95% CI: 1.14- 5.85) were associated with family history of mental illness. Poor academic performance was associated with anxiety (OR=2.75; 95% CI: 1.35- 5.61) and stress (OR=2.00; 95% CI: 1.05-3.81). Conclusions: The prevalence of psychological distress among allied health sciences students is high, especially among students with poor academic performance and those with a family history of mental illness. Psychological distress can be prevented with early detection and awareness programmes.
DETEKSI E. coli PENGHASIL Extended Spectrum Beta-Lactamase (ESBL) MENGGUNAKAN METODE PCR PADA SAMPEL AIR BERSIH
Authors: Rahmawati Lella , Sasongkowati Retno , Anggraini Anita , Adam Deddy
Published: August 2022

Escherichia coli is a normal flora in the human body that plays an important role in the digestive process. The presence of Escherichia coli ESBL (Extended Spectrum Beta-Lactamase) bacteria in clean water samples indicates environmental pollution originating from feces. The aquatic environment is the most influential ecosystem in human life. These contaminated ecosystems provide optimal conditions for antibiotic-resistant bacteria from various sources to mix and transfer their resistance genes to clinically important bacteria for the development of human pathogens with novel resistance mechanisms. This study aims to determine the percentage of ESBL-producing E. coli bacteria in clean water samples.
This study uses a descriptive observational design. The total sampling is 195 clean water samples. After going through screening in the form of membrane filter tests, KIA, and IMVIC, 25 isolates were found which were declared as E. coli. Analysis of the ESBL-producing E. coli gene using conventional PCR. Analysis of the Molecular Weight value in the sample using the GelAnalyzer 19.1 application.
Based on these calculations, it was found that samples of E. coli isolates containing the ESBL gene were 24% of the 25 E. coli isolates. This percentage indicates that there is a large enough contamination in clean water. The results of this study indicate a potential risk to public health. The participation of health workers, government and the community in maintaining sanitary hygiene is needed to avoid greater contamination of antibiotic-resistant bacteria.
Inclusive growth
Authors: van  Niekerk Arno J
Published: August 2022

Sustainable economic growth requires inclusive growth. The former means a rate of growth that can be maintained without the trade-off between rapid economic growth today, and growth in the future, creating major economic problems.68 Rapid growth today may exhaust resources and create environmental problems for future generations, so it needs a type of growth that is inclusive, not just in terms of outcome (sustainable development) but also in terms of the growth process. In both developed and developing economies, few things matter more to society than growth and stability, yet few things are more contentious.
The impact of the Covid-19 pandemic on international trade, with specific reference to the role of trade documentation
Authors: Hugo Charl
Published: August 2022

In this contribution, the author explains the importance of the documents used in international trade and how they feature in payment transactions in this context. The role of different rules of the International Chamber of Commerce (ICC)—especially the Uniform Customs and Practice for Documentary Credits (UCP) and the Uniform Rules for Collections (URC)—are explained, as well as the development of companion rules by the ICC to facilitate trade digitisation—especially the electronic supplement to the UCP (the eUCP), the Uniform Rules for Bank Payment Obligations (URBPO) and the Uniform Rules for Digital Trade Transactions—are analysed. The point is made that the trade digitisation envisaged by these rules has not really taken place to a significant extent. The author then points towards two disasters that have occurred during the past two decades, namely the eruption of Eyjafjallajökull in Iceland in 2010 and the COVID-19 pandemic in 2020, as potential catalysts to speed up trade digitisation. The conclusion is that the volcanic eruption (which halted air traffic in Europe for a week causing massive delivery problems for couriers of documents with major knock-on effects for international trade) may have been a timely wake-up call, but the world soon fell asleep again. He concludes that the COVID-19 pandemic should not lead to the same lack of action, and that all role players should come together urgently to enable worldwide trade digitisation. He argues that this initiative should be driven by the International Chamber of Commerce.
The impact of Covid-19 on domestic violence in South Africa
Authors: Boniface AE
Published: August 2022

COVID-19 and the resulting lockdown has had a negative impact on domestic violence in South Africa. It is known that pandemics increase violence against women. Some of the impacts that domestic violence has on family law is that a surge of domestic violence can lead to an increase in divorces; an increase in application for care and protection orders for children as well as removals of children from the home environment when it is in their best interests. This chapter explores this impact by examining the definitions of domestic violence and gender-based violence and the statistics available regarding domestic violence in South Africa. After that the provisions of the Domestic Violence Amendment Bill and other measures taken by the South African government to assist victims of domestic violence are discussed. The chapter also briefly examines the role that patriarchy plays in driving domestic violence in South Africa. From this study, it emerges that violence against women in South Africa is linked to various factors including patriarchy, economic dependency and expected roles of women. Here it is seen that women need to be empowered and we need to actively change society’s beliefs surrounding the role of women. Additionally, there is an intersection between violence against women and violence against children. The conclusion is reached that the COVID-19 pandemic and the resulting lockdown has exacerbated pre-existing problems in South African society that cause domestic violence and that legislation alone is not sufficient to solve the problem of domestic violence in South Africa. We also cannot rely on statistics alone and need to look at the lived experiences of women in South Africa.
SISTEM PEMASARAN PRODUK SAFE DEPOSIT BOX IB AR-RAHMAN PADA BANK BPD KALSEL SYARIAH CABANG KOTA BANJARMASIN
Authors: Sadino Sadino , Kamilah Yulia
Published: August 2022

Abstrak- Krisis ekonomi dan moneter yang terjadi di Indonesia pada kurun waktu 1997-1998 merupakan pukulan yang sangat berat bagi sistem perekonomian Indonesia. Dalam periode tersebut banyak lembaga-lembaga keuangan, termasuk perbankan mengalami kesulitan keuangan. Seiring dengan diberlakukannya dual banking system oleh Undang-Undang Nomor 10 Tahun 1998 Tentang PerbankanBerdasarkan. Undang – Undang Nomor 21 tahun 2008 tentang Perbankkan Syariah, pengertian Perbankkan Syariah adalah segala sesuatu yang menyangkut tentang Bank Syariah dan Unit Usaha Syariah., mencakup kelembagaan, kegiatan usaha, serta cara dan proses dalam melaksanakan kegiatan usahanya (pasal 1 angka 1). Sedangkan yang dimaksud dengan bank adalah badan usaha yang menghimpun dana dari masyarkaat dalam bentuk kredit dan/atau bentuk lainnya dalam rangka meningkatkan taraf hidup rakyat (pasal 1 angka 2) Dengan demikian, lembaga perbankan yang kegiatan usahanya berdasarkan pada prinsip-prinsip syariah maka dapat dikatakan sebagai perbankan syariah. Kerangka hukum pengembangan industri perbankan syariah diwadahi dalam Undang-Undang Nomor 7 Tahun 1992 tentang Perbankan yang memperkenalkan “sistem bagi hasil” atau “prinsip bagi hasil” dalam kegiatan perbankan nasional. Setelah lahirnya UndangUndang Nomor 10 Tahun 1998 tentang Perubahan atas Undang-Undang Nomor 7 Tahun 1992 tentang Perbankan, bank Islam tersebut tidak lagi dinamakan dengan “bank berdasarkan prinsip bagi hasil”, tetapi dengan nama baru, yakni “Bank Berdasarkan Prinsip Syariah”.

Kata Kunci: Kasus, Perbankkan, Hukum, .
Telaah Semiokognitif Video Penembakan Teroris di Mesjid Christchurch, Selandia Baru
Authors: Muwaffaq Thafhan
Published: August 2022

Abstrak-Semiotik kognitif film berasumsi bahwa film merupakan media komunikasi dan memiliki tujuh tingkat realitas. Saya tidak akan menyebutkan seluruhnya, sementara berfokus pada dua tingkat terdalam yakni realitas spektatorial dan realitas kreasional, yang dibangun oleh representasi pada film. Setidaknya ada tiga jenis informasi langsung yang diresepsi penonton yakni; visual, auditorial, dan kinestetik yang merepresentasikan kejadian secara langsung. Informasi auditorial juga tersedia dalam video, walaupun terbatas pula karena unsur teknis pengambilan adegan tidak didukung peralatan mumpuni dan terencana sebagaimana film dalam industri. Memang hanya dua senjata yang nampak digunakan pada video, dan jerigen yang dapat digunakan sebagai peledak sempat dipegang walaupun tak digunakan pula. video berunsur provokatif si teroris Brenton Tarrant sangat memungkinkan memperkuat motif apapun dalam kelompok yang berseberangan untuk melakukan tindak terorisme balasan.

Kata Kunci : Semiotik, Terorisme, Visual
PERJANJIAN BERSAMA DALAM PENYELESAIAN SENGKETA HUBUNGAN INDUSTRIAL
Authors: Anshori Moch , Lutfi Anas , Syafrizal Syafrizal
Published: August 2022

Abstrak- Perselisihan Pemutusan hubungan kerja adalah perselisihan yang timbul
sebagai akibat tidak adanya kesesuaian pendapat mengenai pengakhiran
hubungan kerja yang dilakukan oleh salah satu pihak. Pemutusan hubungan
kerja (PHK), tidak saja diatur dalam UU No. 2 Tahun 2004, akan tetapi juga
dalam Undang-Undang No. 13 Tahun 2003 tentang Ketenagakerjaan. Rumusan
Masalah dalam penelitian ini adalah: Bagaimanakah keabsahan kesepakatan
dalam bentuk perjanjian bersama pengakhiran hubungan kerja ditinjau dari
peraturan perundangan dan yurisprudensi terhadap upaya penyelesaian
hubungan industrial non litigasi? Metode penelitian yang digunakan dalam
penelitian ini adalah metode penelitian hukum normatif. Teori yang digunakan
mengacu pada Teori Kebebasan Berkontrak dan Efektivitas Hukum. Kesimpulan
yang dihasilkan adalah bahwa Perjanjian Bersama yang sudah ditandatangani
tetapi belum didaftarkan ke pengadilan tidak dapat dibatalkan atau diingkari oleh
salah satu pihak. Karena Perjanjian Bersama mengikat para pihak bagai Undang
Undang.

 

Kata Kunci: Perjanjian Bersama, Pemutusan Hubungan Kerja, Hubungan
Industrial.
BÜTÜNLEŞTİRMENİN ÖZEL GEREKSİNİMLİ ÖĞRENCİLER ÜZERİNDEKİ ETKİSİNİN OKUL ÖNCESİ ÖĞRETMEN GÖRÜŞLERİNE GÖRE İNCELENMESİ
Authors: ERÇİÇEK Buket , ÜNAY Ebru , GÜNAL Yurdagül
Published: August 2022

Bu çalışmada, bütünleştirmenin özel gereksinimli bireyler üzerindeki etkisine yönelik görüşlerin okul öncesi öğretmenlerinin kıdem, sınıfta özel gereksinimli öğrenci bulunma ve bütünleştirmeyle ilgili eğitim alma durumuna göre farklılaşıp farklılaşmadığının incelenmesi amaçlanmıştır. Araştırmanın çalışma grubu, Türkiye’de okul öncesi öğretmeni olarak görev yapan 171 öğretmenden oluşmaktadır. Araştırma verileri Rafferty & Griffin tarafından geliştirilen, Şahbaz, Atılgan ve Aydemir tarafından Türkçeye uyarlanan “Bütünleştirmenin Özel Gereksinimli Çocuklar Üzerindeki Etkisi Ölçeği (BÖGÇÜE)” ile toplanmıştır. Ölçek, 5’li likert tipi olup Bütünleştirmenin Faydaları (BF) ve Bütünleştirmenin Riskleri (BR) olmak üzere iki alt boyuttan oluşmaktadır. Araştırmadan elde edilen sonuçlara göre bütünleştirmenin özel gereksinimli çocuklar üzerindeki etkisine yönelik okul öncesi öğretmenlerinin görüşlerinin; kıdem yılı, sınıfında özel gereksinimli bireyin olma durumu ve bütünleştirmeyle ilgili eğitim alma durumuna göre istatiksel olarak farklılaşmadığı görülmüştür.
TECNOLOGIA DA INFORMAÇÃO EM SAÚDE E HOSPITAIS DIGITAIS
Authors: Silva Neto Raul Cardoso da
Published: August 2022

Todos os anos, centenas de milhares de pacientes são vítimas de eventos adversos em hospitais no Brasil e no mundo, muitos sofrem danos irreversíveis e muitos outros vão a óbito, resultado de erros de conduta, falta de procedimentos, protocolos e diretrizes clínicas e principalmente a ausência de uma cultura de segurança do paciente.

Este estudo, realizado através de revisão bibliográfica, teve como objetivo demonstrar os benefícios que a tecnologia da informação em saúde e a implantação de processos digitais na operação de um hospital podem otimizar recursos, reduzir custos, aumentar o desempenho das equipes e, acima de tudo, promover o aumento na segurança do paciente. Este trabalho tem como base estudos bibliográficos e análise de casos.

Como principais resultados foi possível observar que através da tecnologia da informação aplicada a saúde, com a implementação de sistemas como prontuário eletrônico, sistemas de controle de administração de medicamentos, sistemas de apoio a decisão, diretrizes clínicas, etc. o índice de efeitos adversos relacionados a erros de medicação, reações adversas, entre outros, diminui consideravelmente, e o estabelecimento de protocolos e diretrizes apoiados pela tecnologia da informação aumentam a qualidade do tratamento proporcionado pelas equipes.
PERCENTUAL DE READMISSÃO DE PACIENTES NO AMBIENTE HOSPITALAR COMO PARÂMETRO DA QUALIDADE DA ASSISTÊNCIA
Authors: Mota Luiz Cláudio Mota
Published: August 2022

Indicadores são usados para melhorar a gestão dos serviços de saúde fornecendo informações visando tomadas de decisão. O objetivo desse trabalho é reconhecer, através de revisão bibliográfica e análise de dissertações e teses, como o percentual de readmissão hospitalar pode impactar na gestão de leitos hospitalares, conhecer as causas de maior prevalência para a (re) internação hospitalar e destacar a importância da transição do cuidado e do planejamento de ações para eliminar/minimizar as causas da reinternação, evidenciando a importância dos prejuízos gerados pelas mesmas, além do seu impacto sobre os sistemas de saúde considerando aspectos organizacionais, econômicos e sociais. Conclui-se que, apesar de diferenças metodológicas que podem causar dificuldade em sua implantação, o percentual da readmissão hospitalar serve como base para o estudo de diversas ações visando à melhoria da qualidade assistencial.
Optimalisasi Media Promosi Objek Wisata Pantai Kutang Lamongan Jawa Timur
Authors: Ainun Nur Janin Islam Khusnul , Anwar Miftahol , Ramadhan Ishaq Bima , Mardiyanti Aprita Dwi , Nugroho Nabila Landiana , Oktarina Riesta Ayu
Published: August 2022

Program KKL kelompok kami akan membantu mengoptimalkan media publikasi pada Wisata Pantai Kutang Lamongan. Melihat dari permasalahan wisata pantai Kutang, yang dapat kami simpulkan mengenai media sosial promosi yang selalu berubah-ubah dan sajian foto yang kurang menarik perhatian warganet membuat kami ingin menghasilkan sebuah karya foto dan video dengan suguhan apik yang sudah kami pelajari di kampus. Kami mencoba mengaplikasikan materi yang sudah diajarkan oleh dosen dalam bidang fotografi dan videografi untuk membantu meningkatkan angka wisatawan di tengah pandemi ini. Harapan dari kelompok kami setelah terlaksanakannya program KKL yang kelompok kami rencanakan dapat memberi energi positif adanya peningkatan jumlah pengunjung pantai Kutang Lamongan.
Faktor Risiko Kejadian Penyakit Kusta di Puskesmas Kotaraja
Authors: Tuturop Katarina Lodia , Adimuntja Natalia Paskawati , Borlyin Dian Eva
Published: August 2022

Leprosy is a disease caused by Mycobacterium leprae. Which attacks various parts of the body. If left untreated, leprosy is very progressive causing damage to the skin, nerves, limbs and eyes. This study aims to determine the risk factors for the incidence of leprosy at the Kotaraja Public Health Center. This type of research is observational, with a case control study design. The population of the case group is people with leprosy and the population of the control group is neighbors with leprosy using purposive sampling technique, all populations in 2021. The sampling technique uses total sampling, the number of samples is 50 respondents with 1:1 criteria, namely 25 cases and 25 controls. Data were analyzed using the Odds Ratio (OR) test. The results showed that there was a risk between education level (OR= 11.1,  95%  CI:  2.86-43.46)  contact  history  (OR=  13.5  95%  CI:1.55-117.13), regularity treatment (OR=6,68,95% CI: 1,76-25,24), family support (OR= 5,63, (95% CI:1,64-19,23) with the incidence of leprosy. While there is no risk between age (OR=0.47, 95% CI: 0.41-5.65) gender (OR=2.11, 95% Cl: 0.62-7.13) and the incidence of leprosy.
Diagnostic Efficiency of Inflammatory Prognostic Index on Pain Scoring for Degenerated Intervertebral Disc
Authors: FİRİDİN Mustafa Nevzat , AKYÜZ Mehmet Emin
Published: August 2022

Aim: Inflammatory Prognostic Index (IPI), calculated via Albumin, CRP and Neutrophil-Lymphocyte Ratio (NLR), is used in the inflammation related diseases. The study focused the efficacy and predictive effect of the IPI in terms of Visual Analog Scales (VAS) for interpretation of back and leg pain. Materials and Methods: This multicenter retrospective clinical study was performed by the hospital records of the Degenerated Intervertebral Disc (DIVD) treated between January 2020 and February 2022. IPI value was calculated by the formula of “CRPxNLR/Albumin”. Results: There was a significant difference between VAS-B (2.38±1.74; p=0.0001) and VAS-L (7.09±1.44; p=0.00017) in the comparison of paired VAS values before and after the surgery. Similar change occurred within walking distance after surgery. According to the correlation analysis of the IPI index with DIVD pain scoring, VAS-B(r=0.391; p=0.00017) and delta VAS-B (r=0.422; p=0,00004) showed a positive correlation with the IPI. In the ROC analysis for the diagnostic value of the IPI, the cut-off value of VAS-L above 0.184 showed a diagnostic value as 78.9% sensitivity and 64.3% specificity (UAC:0.702; p:0.003; CI%95: 0.581-0.815). Conclusion: We showed a strong relationship between IPI and pain scoring of DIVD. The diagnostic value of IPI with VAS-L was very important and can be used by physicians for pain follow-up of DIVD.
The Precise Location of the Stylomastoid Foramen and Clinical Implication for Facial Nerve Block
Authors: BABACAN Serdar , BAYAT Rohat , BÜYÜKFIRAT Evren , DENİZ Mustafa
Published: August 2022

Aim: We aimed to develop linear regression formulas for determining the precise localization of the stylomastoid foramen on the base of the morphometric features of the person’s own skull.

Material and Method: The study was conducted on 22 stylomastoid foramina (11 skulls). The 10 parameters determined for the stylomastoid foramen were measured on the photographs taken from the skull base and the 17 parameters determined for the morphometric features of the skull were measured on the photographs taken from the anterior plane, lateral plane, and posterior plan using Image J measurement software. The data obtained were evaluated with SPSS 20.0 statistical software.

Results: To determine the morphometric and topographic features of the stylomastoid foramen the equations have been developed such as; P1 (The distance between stylomastoid foramen and root of the zygomatic arch)=18.758+(0.472xP12)-(2.092x P16)+(0.831xP17)–(0.390xP18)–(0.101x P20); Adjusted R2=0.865, Standard Error of the Estimation=1.389.

Conclusion: Mean values can give misleading information in determining the topographical relationship between the stylomastoid foramen and the surrounding anatomical structures. We have developed regression formulas that will estimate the accurate location of the stylomastoid foramen and the accurate distances between other surrounding anatomical structures, taking into account the morphometric characteristics of the person’s own skull.
LOCAL LINEAR MODELLING OF THE CONDITIONAL DISTRIBUTION FUNCTION FOR FUNCTIONAL ERGODIC DATA
Authors: Ayad Somia , Laksaci Ali , Rahmani Saâdia , Rouane Rachida
Published: August 2022

The focus of functional data analysis has been mostly on independent functional observations. It is therefore hoped that the present contribution will provide an informative account of a useful approach that merges the ideas of the ergodic theory and the functional data analysis by using the local linear approach. More precisely, we aim, in this paper, to estimate the conditional distribution function (CDF) of a scalar response variable given a random variable taking values in a semimetric space. Under the ergodicity assumption, we study the uniform almost complete convergence (with a rate), as well as the asymptotic normality of the constructed estimator. The relevance of the proposed estimator is verified through a simulation study.
AN EXPLICIT SPECTRAL COLLOCATION METHOD FOR THE DRUG RELEASE CORONARY STENTS
Authors: Fakhri Somayeh , Momeni-Masuleh Sayed Hodjatollah
Published: August 2022

This research aims to solve a comprehensive one-dimensional model of drug release from cardiovascular stents in which the drug binding is saturable and reversible. We used the Lagrange collocation method for space dimension and the modified Euler method for time discretization. The existence and uniqueness of the solution, are provided. The consistency, stability, and convergence analysis of the proposed scheme are provided, to show that numerical simulations are valid. Numerical results accurate enough and efficient just by using fewer mesh.
Implicit Solar Coronal Magnetohydrodynamic (MHD) Modeling with a Low-dissipation Hybridized AUSM-HLL Riemann Solver
Authors: Wang Haopeng , Xiang Changqing , Liu Xiaojing , Lv Jiakun , Shen Fang
Published: August 2022

In this paper, we develop a 3D implicit single-fluid magnetohydrodynamic (MHD) model to simulate the steady-state solar corona with a wide range of Mach numbers and low plasma β. We employ a low-dissipation advection upstream splitting method (AUSM) to calculate the convective flux in the regions of low Mach numbers for a high resolution, and hybridize the AUSM with Harten-Lax-van Leer Riemann solver in the regions of high Mach numbers to improve the solver’s robustness. The inner boundary condition of no backflow is implemented by numerical flux. A reconstruction method based on the divergence-free radial basis function is adopted to enhance the divergence-free constraint of magnetic field. Also, an anisotropic thermal conduction term is considered; the positivity-preserving reconstruction method is used to prevent the presence of negative thermal pressure and plasma density, and the implicit lower-upper symmetric Gauss Seidel method is implemented for a better convergence rate. After establishing the implicit solar wind MHD model, we employ it to simulate steady-state solar coronal structures in Carrington rotations 2177 and 2212. The simulations demonstrate that the MHD model’s computational efficiency is desirable, and the modeled results are basically in agreement with the solar coronal observations and the mapped in situ measurements from the OMNI archive. Consequently, this implicit MHD model is promising to simulate a complex plasma environment with high-intensity magnetic field and wide-ranging Mach numbers.
Fermi LAT Gamma-ray Detection of the Recurrent Nova RS Ophiuchi during its 2021 Outburst
Authors: Cheung C. C. , Johnson T. J. , Jean P. , Kerr M. , Page K. L. , Osborne J. P. , Beardmore A. P. , Sokolovsky K. V. , Teyssier F. , Ciprini S. , Martí-Devesa G. , Mereu I. , Razzaque S. , Wood K. S. , Shore S. N. , Korotkiy S. , Levina A. , Blumenzweig A.
Published: August 2022

We report the Fermi LAT γ-ray detection of the 2021 outburst of the symbiotic recurrent nova RS Ophiuchi. In this system, unlike classical novae from cataclysmic binaries, the ejecta from the white dwarf form shocks when interacting with the dense circumstellar wind environment of the red giant companion. We find the LAT spectra from 50 MeV to ∼20–23 GeV, the highest-energy photons detected in some subintervals, are consistent with π
0-decay emission from shocks in the ejecta as proposed by Tatischeff & Hernanz for its previous 2006 outburst. The LAT light curve displayed a fast rise to its peak >0.1 GeV flux of ≃6 × 10−6 ph cm−2 s−1 beginning on day 0.745 after its optically constrained eruption epoch of 2021 August 8.50. The peak lasted for ∼1 day and exhibited a power-law decline up to the final LAT detection on day 45. We analyze the data on shorter timescales at early times and found evidence of an approximate doubling of emission over ∼200 minutes at day 2.2, possibly indicating a localized shock-acceleration event. Comparing the data collected by the American Association of Variable Star Observers, we measured a constant ratio of ∼ 2.8 × 10−3 between the γ-ray and optical luminosities except for a ∼5×smaller ratio within the first day of the eruption likely indicating attenuation of γ rays by ejecta material and lower high-energy proton fluxes at the earliest stages of the shock development. The hard X-ray emission due to bremsstrahlung from shock-heated gas traced by the Swift-XRT 2–10 keV light curve peaked at day ∼6, later than at GeV and optical energies. Using X-ray derived temperatures to constrain the velocity profile, we find the hadronic model reproduces the observed >0.1 GeV light curve.
Anxiety Disorders and Prediction of Their Development in Patients with Hypothyroidism and Autoimmune Thyroiditis
Authors: Kamyshna Iryna , Pavlovych Larysa , Pankiv Volodymyr , Pankiv Ivan , Kamyshnyi Aleksandr
Published: August 2022

Objective: Since the association between thyroid dysfunction and neuropsychiatric disorders has been known for many years, it is important to analyze the associations of the BDNF gene polymorphism (rs6265), the VDR gene polymorphism (rs2228570), and the NMDA gene polymorphism (rs4880213) with the anxiety in patients with autoimmune thyroiditis and hypothyroidism in the Western Ukrainian population and predict the development of anxiety disorders in these patients.
Methods: The study involved a total of 153 patients with various forms of thyroid pathology. BDNF levels in the sera of the patients and healthy individuals were quantified using an enzyme-linked immunosorbent assay with a highly sensitive Human BDNF ELISA Kit (Elabscience®, United States, Catalog No: E-EL-H0010) on E.I.A. Reader Sirio S (Seac, Italy). Genotyping of the VDR (rs2228570), BDNF (rs6265), and NMDA (rs4880213) gene polymorphism using TaqMan probes and TaqMan Genotyping Master Mix (4371355) on CFX96™Real-Time PCR Detection System (Bio-Rad Laboratories, Inc., USA). Polymerase chain reaction (PCR) for TaqMan genotyping was carried out according to the kit instructions (Applied Biosystems, USA).
Results: According to the data obtained when comparing the presence of anxiety on the Hamilton scale on SNP statistically significant differences were revealed depending on BDNF gene polymorphism (rs6265) (p < 0.001). When comparing the presence of anxiety on the Hamilton scale on SNP depending on VDR gene polymorphism (rs2228570), NMDA gene polymorphism (rs4880213) no statistically significant differences were revealed (p = 0.782, p = 0.677 respectively) We identified an inverse strong correlation between the presence of anxiety on Hamilton scale and BDNF, 25-OH Vitamin D levels, and fT4 in the blood (p <0.001) and a direct moderate correlation between the presence of anxiety on Hamilton scale and TSH, GRIN2B, and anti-TPO (p <0.001).
Conclusion: Indicators such as BDNF, GRIN2B, fT4, anti-TG, and 25-OH levels of vitamin D are prognostically significant risk criteria for anxiety.
Comparison of Serum Vitamin D Level between Normal Pregnancy and Abortion in Outpatient Settings
Authors: Simanjuntak Leo , Simanjuntak Benhard Christopher , Lumbanraja Sarma Nursani
Published: August 2022

Background: Abortion is pregnancy termination or loss before 20 weeks gestation or with a fetus delivered weighing <500 grams. One of the pathogenic mechanisms associated with abortion was immunological factors. The human fetus represents a semi-allograft, which cannot survive without maternal immune tolerance. Vitamin D may be implicated in the risk of miscarriage due to its function as an immune modulator and its potential importance for the maternal-fetal immunologic response
Objective: This study aimed to compare the level of serum vitamin D in abortion patients and normal pregnant women.
Methods: This is a cross-sectional study using primary data from a private maternity clinic in October 2020-February 2021. The subjects recruited in this study were 98 women at first-trimester pregnancy with either viable gestation (46 subjects) or abortion (52 subjects). Demographic data (maternal age, gestational age, BMI, parity level, history of miscarriage, and occupation) and their association to abortion were determined. The serum 25(OH)D level was measured and then compared using statistical analysis.
Results: Mean age of the subjects was 30.45 ± 4.56 years and the mean gestational age of the recruitment was 58.31 ± 17.89 days. Abortion group has lower serum 25(OH)D level (16.95 ± 5,51 mg/L) than normal pregnant group (17.89 ± 4,74 mg/L), although it was not statistically significant (P = 0.527). The results also showed there was no statistically significant association between the classification of vitamin D deficiency, BMI, parity level, history of miscarriage, occupation, and abortion (P > 0.05).
Conclusion: In our study, we found that abortion patients had lower vitamin D levels than normal pregnant women, but it was not statistically significant. Abortion also was not associated with BMI, parity level, history of miscarriage, and occupation
COVID-19 Vaccine Acceptance in Padang City, West Sumatra, Indonesia
Authors: Permatasari Dita , Sari Yelly Oktavia , Ranofan Rifo , Juwita Dian Ayu
Published: August 2022

Background: Indonesia started the COVID-19 vaccination program in January 2021. West Sumatra, Indonesia, as one of the epicentres of the spread of COVID-19, has also begun the vaccination program. However, the Government has conducted no vaccine acceptance survey in this area as done in several other Indonesia regions. Aim: This study aims to see an overview of the acceptance of COVID-19 vaccination in West Sumatra, Indonesia. Methods: A descriptive research with a survey method using a questionnaire instrument given directly to the people of Padang, West Sumatra, Indonesia. The total respondents in this study amounted to 390 people based on inclusion criteria, with the method of taking accidental sampling. Results: This study showed that 38.2% of respondents were willing to be vaccinated, 27.9% refused to be vaccinated, and 33.8% had not decided to accept or reject the vaccine. Most respondents refused the vaccine with fear of side effects 42.9% and were concerned about vaccine safety 33.9%. More than half of the respondents (51.0%) wanted to vaccinate at public health centre. As many as 85.4% of respondents wanted to get more information about the COVID-19 vaccine being developed. Online platforms, print and electronic media are sources of information with about 40.5%, followed by face-to-face communication with 36.0% and social media with 23.5%. Conclusion: The people of Padang who stated that they were willing to undergo the COVID-19 vaccine program had not yet reached half of the number of respondents studied. However, this number has the opportunity to increase based on the enthusiastic trend of people who want to get more information about the COVID-19 vaccine. Providing correct and precise information should encourage the general public to participate in vaccination.
Catherine de Médicis, de la légende à l’histoire. Une question historique mal posée ?
Authors: Turchetti Mario
Published: August 2022

Catherine de Médicis est l’une des figures les plus controversées de l’histoire de France. Cet article propose une analyse de l’idéal de concorde politique et religieuse qui animait la reine mère. Il s’interroge également sur les responsabilités à l’œuvre dans les massacres de la Saint-Barthélemy, et montre que l’imputation à une Italienne des violences de 1572 a permis aux Français de se dédouaner de toute responsabilité dans l’événement.
« Le » Covid-19 est-il plus grave que « la » Covid-19 ? Impact du genre grammatical attribué à la maladie sur sa perception et sur les mesures de protection prises pour s’en prémunir
Authors: Celse Jérémy , Grolleau Gilles , Max Sylvain
Published: August 2022

A priori, les débats concernant le genre de l’article défini devant précéder le terme Covid-19 semblent plutôt relever de considérations grammaticales et linguistiques. Néanmoins, suite à des travaux récents (Farrow et al. [2018]) invitant à examiner de plus près les mots comme des leviers d’influence des perceptions et des comportements humains, nous testons expérimentalement si le choix de l’article devant précéder le terme Covid-19 aurait pu contribuer à des politiques publiques plus efficaces. Les résultats montrent que ce choix apparemment anodin ne l’est pas et suggèrent que, dans le cadre d’une stratégie de lutte contre la propagation du virus, l’article masculin aurait pu être plus opportun.
In vitro assessment of protein digestibility and mineral solubility of black soldier fly larvae meals for monogastric animals
Authors: Silva M.S. , Matos R. , Araujo P. , Lock E.J. , Gopika R. , Prabhu P.A.J. , Belghit I.
Published: August 2022

Animal farming is a fast-growing sector which demands a large supply of feed materials and the search for novel feed ingredients with a smaller impact on the global environment has been intensified. However, before the inclusion of these feed ingredients in animal feed, a preliminary assessment of the quality and performance is needed. This evaluation is usually done by in vivo feeding trials, but in vitro digestion methods have been successfully used for gathering information regarding the nutritional value of the different feed components. Therefore, in this work, an in vitro digestion method was developed using black soldier fly (BSF) larvae meals. The method included seven experimental variables, namely: pH in stomach, pH in intestine, reaction time in stomach, reaction time in intestine, enzyme concentration in stomach, enzyme concentration in intestine and temperature. The experimental variables were screened by means of a fractional factorial design (27-2) that allowed to select the concentration of enzyme in the intestine and temperature (at 7 U and 37 °C, respectively) as the most influential factors on amino acid and mineral solubility in BSF larvae meal. Performing the in vitro digestibility at 37 °C with pH of the stomach and intestine at 2 and 9, reaction time in the stomach and intestine at 1 hour and 4 hours and concentration of enzyme in the stomach and intestine at 1 U and 7 U resulted in the highest overall nutrient solubility. This optimised in vitro digestion methodology was used to assess the nutritional stability of three batches of BSF meals delivered by the same producer. The in vitro digestion method was able to reveal differences between the three batches of BSF meals.
Reinforced MCTS for non-intrusive online load identification based on cognitive green computing in smart grid
Authors: Jiang Yanmei , Liu Mingsheng , Li Jianhua , Zhang Jingyi
Published: August 2022

Cognitive green computing (CGC) is widely used in the Internet of Things (IoT) for the smart city. As the power system of the smart city, the smart grid has benefited from CGC, which can achieve the dynamic regulation of the electric energy and resource integration optimization. However, it is still challenging for improving the identification accuracy and the performance of the load model in the smart grid. In this paper, we present a novel algorithm framework based on reinforcement learning (RL) to improve the performance of non-invasive load monitoring and identification (NILMI). In this model, a knowledge base of load power facilities (LPF-KB) architecture is designed to facilitate the load data-shared collection and storage; utilizing deep convolutional neural networks (DNNs) structure based on the attentional mechanism to enhance the representations learning of load features; using RL-based Monte-Carlo tree search (MCTS) method to construct an optimal strategy network, and to realize the online combined load prediction without relying on the prior knowledge. We use the massive experiment on the real-world datasets of household appliances to evaluate the performance of our method. The experimental results show that our approach has remarkable performance in reducing the load online identification error rate. Our model is a generic model, and it can be widely used in practical load monitoring identification and the power prediction system.
AN ULTRASTRUCTURAL STUDY OF THE ANTARCTIC CALANOID COPEPOD METRIDIA GERLACHEI GIESBRECHT, 1902. ADULT FEMALE
Authors: Mariottini G.L. , Feletti M. , Romano P. , Cadoni A. , Carli A.
Published: August 2022

The Antarctic environment is a peculiar ecosystem still greatly unpolluted and constitutes a true natural laboratory. In Antarctic waters low temperatures strongly affect the composition and structure of biocenosis and the occurrence of the Antarctic Convergence separates the Southern Ocean from surrounding waters. These characteristics led to the development of endemisms; therefore, the study of morphology, physiology, genetics and biochemical composition of Antarctic species are the basic elements to know their adaptive strate gies and to reconstruct evolutionary events. [...]
Staple-line Reinforcement in Laparoscopic Sleeve Gastrectomy
Authors: Bastos Eduardo Lemos de Souza , Ramos Almino Cardoso
Published: August 2022

Laparoscopic sleeve gastrectomy (LSG) has achieved high approval rates as stand-alone weight loss procedure in recent years. Its safety and effectiveness have been clearly established by numerous published studies. On the other hand, there has been great concern about complications related to the long staple line, mainly bleeding and leaks. Although this concern is universal among bariatric surgeons, strategies to prevent complications related to the staple line are not consensual. Accordingly, staple-line reinforcement methods have been widely proposed in an attempt to reduce the risk of these adverse events. However, nonreinforced but technically well-performed staple line can also be a very safe option, saving operative time and procedure-related costs. Therefore, the purpose of this narrative review is to discuss current options for minimizing the risk of staple line-related bleeding and leaks in LSG, focusing on technical issues and reinforcement methods.
Efficacy and safety of folfiri plus aflibercept in second-line treatment of metastatic colorectal cancer
Authors: Erol Cihan , Nahit Sendur Mehmet Ali , Bilgetekin Irem , Garbioglu Duygu Bayir , Hamdard Jamshid , Akbas Sinem , Hizal Mutlu , Arslan Cagatay , Sevinc Alper , Kucukarda Ahmet , Erdem Dilek , Kahraman Seda , Cakir Emre , Demirkiran Aykut , On Sercan , Dogan Izzet , Erdogan Atike Pinar , Koca Sinan , Kubilay Pinar , Eren Orhan Onder , Cilbir Ebru , Celik Emir , Araz Murat , Ozyukseler Deniz Tataroglu , Yildirim Mahmut Emre , Bahceci Aykut , Taskaynatan Halil , Oyman Abdilkerim , Deniz Gulhan Ipek , Menekse Serkan , Kut Engin , Gulmez Ahmet , Sakin Abdullah , Nayir Erdinc , Acar Ramazan , Sen Erdem , Inal Ali , Turhal Serdar , Kaya Ali Osman , Paydas Semra , Tastekin Didem , Hacibekiroglu Ilhan , Cincin Irfan , Bilici Ahmet , Mandel Nil Molinas , Dede Didem Sener , Akinci Muhammed Bulent , Oksuzoglu Berna , Uncu Dogan , Yalcin Bulent , Artac Mehmet
Published: August 2022

Aims:

The addition of aflibercept to the fluorouracil and irinotecan (FOLFIRI) regimen significantly improved clinical outcomes in patients with metastatic colorectal cancer (CRC) previously treated with oxaliplatin. We aimed to investigate the efficacy and safety of second-line FOLFIRI and aflibercept combination in patients with metastatic CRC in real-life experience.

Materials and Methods:

Four hundred and thirty-three patients who treated with FOLFIRI and aflibercept in the second-line were included in the study. The clinical and pathological features of the patients were recorded retrospectively. Survival (overall and progression-free survival [PFS]), response rates, and safety data were analyzed.

Results:

The median age was 61. Majority of patients (87.5%) received first-line bevacizumab and 10.1% of patients received anti-epidermal growth factor receptor agents. About 80% of patients had KRAS, 18.6% of patients had NRAS, and 6.4% of patients had BRAF mutations. The median OS was 11.6 months (95% confidence interval [CI], 10.6–12.6) and the median PFS was 6 months (95% CI, 5.5–6.5). About 4.6% of patients had complete response and 30.6% of patients had partial response as best tumor response. Grade 1–2 toxicities were seen in 33.4% of patients, while grade 3–4 toxicities were recorded in 27% of patients. Eight patients (2%) died due to treatment toxicity.

Conclusions:

Overall and PFS were similar in routine clinical practice compared to phase III pivotal VELOUR trial. However, response rates were found to be higher. It was observed that there were fewer adverse events compared to the VELOUR trial.
An unusual infection with long-term bevacizumab treatment for advanced nonsmall-cell lung cancer
Authors: Erol Cihan , Nahit Sendur Mehmet Ali , Yalçin Bülent
Published: August 2022

Bevacizumab is an angiogenesis inhibitor with Food and Drug Administration approval for multiple tumor types (including colon, nonsquamous nonsmall-cell lung cancer, kidney and glioblastoma multiforme, cervix, and ovarian cancer). Here, we present a patient with actinomycosis who was on treatment with bevacizumab maintenance therapy following chemotherapy combined with bevacizumab. A 60-year-old male patient with lung adenocarcinoma was treated four cycles of carboplatin, paclitaxel with bevacizumab. And then, bevacizumab maintenance therapy was continued. After 38 months of bevacizumab maintenance, computed tomography showed a newly developed cavitary lesion in the upper lobe of the right lung. Bronchoscopy was performed and the pathology report of the biopsy was reported as actinomycosis. Bevacizumab treatment was discontinued and the patient was treated with amoxicillin-clavulanate. To our knowledge, our case is the first case of actinomycosis infection due to the possible bevacizumab treatment.
Fasting Serum C-Peptide Level May not be Low in Young-Onset Diabetes
Authors: Hosen Mobarak , Sultana Nusrat , Hasan Mashfiqul , Jahan Sharmin , Jahangir-Alam Mohammad , Islam Shadequl , Rahman Saifur , Tanvi Noor E Jannat , Fariduddin Mohammad , Hasanat Muhammad A.
Published: August 2022

Background:

Diabetes mellitus (DM) is one of the growing health problems among the young population. Secretory defect of insulin is an important cause, and it can be assessed by measuring fasting serum C-peptide level.

Aim:

The aim of this article is to assess fasting serum C-peptide in young-onset DM individuals.

Materials and Methods:

This case–control study was conducted in the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2015 to February 2017. For this purpose, 40 individuals with DM (irrespective of DM type; age range: 11–29 years) were enrolled as case and an equal number of young healthy individuals as control. Demographic profiles, clinical profiles, and serum C-peptide were recorded in a standard and pre-tested structured datasheet. C-peptide was measured by the chemiluminescent immunometric assay.

Results:

Median fasting C-peptide was 2.67 [interquartile range (IQR) 1.06–4.07, range 0.12–20.0] ng/mL in diabetes individuals, whereas it was 2.19 (IQR 1.36–2.94, range 0.44–9.85) ng/mL in the control group; the difference was insignificant (P = 0.331). Waist circumference (WC) was significantly higher in the young diabetes group in comparison to that of control subjects and so were the plasma glucose values and diastolic blood pressure (P < 0.05 for all). Diabetic participants with low C-peptide group had significantly lower body mass index (BMI) and WC and higher fasting plasma glucose (FPG) and HbA1c in comparison to others (P < 0.05 for all); whereas the high C-peptide group had opposite body indices (higher BMI and WC) and glycemic parameters (lower FPG and HbA1c) (P < 0.05 for all). The classic hyperglycemic symptoms were more common in the low C-peptide group (P = 0.029). In participants with diabetes, C-peptide positively correlated with BMI and WC, whereas it showed a negative correlation with age (P < 0.05 for all). In the control group, C-peptide positively correlated with WC only (P = 0.018).

Conclusion:

The level of fasting serum C-peptide in diabetic subjects was similar to healthy controls, and it was higher in those subjects who had higher BMI, WC, and lower age.
Bioequivalence Study of Two Different Dapagliflozin Tablet Formulations in Healthy Adult Indian Volunteers
Authors: Kalra Sanjay , Bhattacharya Supratik
Published: August 2022

Objective:

To assess the bioequivalence of 10 mg dapagliflozin tablets compared with that of 10 mg Farxiga® (dapagliflozin) tablets of AstraZeneca Pharmaceuticals LP, USA in healthy, adult volunteers under fasting conditions.

Materials and Methods:

This was an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, oral bioequivalence study. Volunteers were randomized to receive either test product or reference product of 10 mg dapagliflozin tablets under the fasting condition with a nine-day washout period. The primary pharmacokinetic (PK) parameters were maximum plasma concentration (Cmax), area under the curve (AUC) at time t (AUCt), and AUC extrapolated to infinity (AUCinf). Adverse events were assessed as safety endpoints. The bioequivalence was assessed to evaluate that the two formulations are not different from one another if the 90% confidence interval for the ratio of the geometric least square means falls completely within the predefined range of 80–125%.

Results:

Fifty-two healthy adult volunteers were randomized, and 47 completed the study. The mean values for Cmax, AUCt, and AUCinf were almost identical for test and reference products after administration to healthy human volunteers under fasting conditions. A total of 14 adverse events were reported by 10 volunteers during the study. All adverse events were mild to moderate in nature and did not cause study withdrawal.

Conclusion:

The test product dapagliflozin 10 mg was bioequivalent with the reference product in healthy, adult, human volunteers under fasting conditions. The availability of the affordable generic dapagliflozin has the potential to improve clinical outcomes in millions of patients in India because of its renoprotective, cardioprotective, and glucose-lowering effects.