bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternatives to mental health admissions for children and adolescents experiencing mental health crises: A systematic review of the literature
Authors: Clisu Denisa A , Layther Imogen , Dover Deborah , Viner Russell M , Read Tina , Cheesman David , Hodges Sally , Hudson Lee D
Published: November 2021

Background: Many children and young people (CYP) presenting with mental health crises are admitted to hospital due to concerns around illness severity and risk. Whilst inpatient admissions have an important role for such children, there are a number of burdens associated with them, and safe avoidance of admissions is favourable. We systematically reviewed the literature for studies of interventions reported as alternatives to a hospital admission in CYP presenting with mental health crises, in any inpatient setting. Methods: Three databases (PsychInfo, PubMed and Web of Science) were searched for peer-reviewed papers in October 2020, with an updated search in May 2021. Results: We identified 19 papers of interventions delivered in the emergency department, the home, outside of home but outside of clinics and in hospital clinics. The quality of most included studies was low, with less than half being randomised controlled trials and only half of these at low risk of bias. The best quality studies and greatest evidence for efficacy came from in-home interventions, in particular multisystemic therapy, which improved psychological outcomes, and though a large number of CYP still ended up being admitted, there appeared to be decreased length of stay. Conclusions: Overall, we could not recommend a particular intervention as an alternative to inpatient admission; however, our review describes benefits across a range of types of interventions that might be considered in multi-modal treatments. We also provide recommendations for future research, in particular the evaluation of new interventions as they emerge.
Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1 infected patients: 336-week rollover study of phase 2b and 3 clinical studies
Authors: Molina Jean Michel , Ene Luminita , Cahn Pedro , Fätkenheuer Gerd , Van Wijngaerden Eric , Lombaard Johan , Zakharova Natalia , Van Eygen Veerle , Vanveggel Simon , Van Solingen-Ristea Rodica
Published: November 2021

Background

To evaluate the long-term safety and efficacy of rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), in combination with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in human immunodeficiency virus (HIV)–infected patients.

Methods

RPV-treated HIV-infected patients from phase 2b or 3 studies rolled-over into this phase 3, open-label study and received RPV 25 mg once daily (QD) with choice of two NRTIs. Adverse events (AEs), plasma viral load, CD4+ cell count, and antiviral resistance were evaluated.

Results

Of the 482 patients treated, 437 (>90%) patients discontinued study treatment; 371 (77%) had switched to commercially available RPV, 14 (2.9%) discontinued due to AEs, and 6 (1.2%) had virologic failure. In this rollover study, patients were followed up to week 336, although data was limited beyond 288 weeks. Forty-five (9.3%) patients were still undergoing treatment at the time of data cut-off for the current analysis (8 February 2018). The most frequently reported AEs were pregnancy in 7 (1.5%) patients and syphilis in 5 (1.0%) patients. Grade 3–4 AEs were reported in 17 (3.5%) patients, and AEs possibly related to RPV in 23 (4.8%) patients. Over 288 weeks of treatment, 80.1% (95% CI: 74.9%; 84.3%) of patients maintained virologic suppression (HIV-1 RNA <50 copies/mL). The absolute CD4+ cell count increased over time until week 192 and remained constant thereafter.

Conclusions

RPV 25 mg QD in combination with an investigator-selected background regimen of two NRTIs demonstrated sustained long-term virologic suppression. The treatment was well-tolerated with no new safety findings.
Pre-electoral coalitions and cabinet stability in presidential systems
Authors: Albala Adrián , Borges André , Couto Lucas
Published: November 2021

Previous research on coalition stability in presidential systems has relied to a substantial extent on the parliamentary literature. By focusing on the post-electoral bargaining environment, these approaches have neglected the key role played by pre-electoral agreements formed around the winning presidential candidate in the making and breaking of coalitions under presidentialism. We claim that cabinets derived from pre-electoral coalition should foster trust and reduce uncertainty regarding partners’ future behaviour. However, the positive effect of pre-electoral coalitions over cabinet duration is conditional on cabinet status, that is, the control of a legislative majority or near majority. Therefore, we argue that pre-electoral coalition cabinets holding a majority or near majority of seats will be more durable than purely post-electoral majority coalitions, whereas minority pre-electoral coalition cabinets congruent should endure less than minority post-electoral coalition cabinets. We test these hypotheses using a dataset of pre- and post-electoral coalitions in 11 Latin American countries.
Regulating and representing camming: Strict limits on acceptable content on webcam sex platforms
Authors: Stegeman Hanne Marleen
Published: November 2021

This article analyses the discursive construction of the limits of webcamming in terms of service agreements by BongaCams, LiveJasmin and Chaturbate, three of the world’s most popular webcam sex platforms. Through this analysis, the moderation practices in the webcamming industry are examined. Regulation of sexual platforms and its implications for representations of online sex work are still largely unclear. Through a critical discourse analysis of seven webcam platform terms of service documents, this article scrutinises the norms for camming as dictated by industry leading platforms. This analysis shows that these platforms, for legal and financial reasons, reject the idea of camming as sexually explicit or as (sex) work. Such a construction of camming limits sexual expression online, obstructs online sex workers’ labour rights and perpetuates sex work stigma. This article sheds light on how digital platforms can establish and maintain norms which regulate users’ online expressions, working conditions and representations.
Bolognina gym
Authors: Scandurra Giuseppe
Published: November 2021

Abstract

This article describes the social organization of the ‘Tranvieri’ boxing gym in Bolognina, a working class Bologna neighbourhood that has seen rapid change over the last 20 years due to the closure of factories and arrival of immigrants, especially from the Maghreb. The population of the gym has changed accordingly: currently, about two-thirds of those attending the gym as a leisure centre are children of immigrants. I have studied the practices of everyday life, the ‘techniques of the body’ of these young boxers born in Italy but without citizenship, who frequent the gym daily after vocational school or work and attending to family responsibilities. For these young men, boxing is not a solution to the frustrations inflicted by a social world they perceive as indifferent, if not hostile, towards them; rather, it offers them a chance to be represented within that world as something other than merely excluded. As scholars have shown, boxing is a male world: women are perceived as extraneous to the gym and, although two or three women practise boxing at Tranvieri, female boxing is generally met with disapproval. The tension between the boxing world and the world of women is also exhibited in the conflict between trainers, who wish to strictly control the athletes in terms of diet, schedules and sexual practices, and the boxers’ mothers, wives and girlfriends.
Physician-Modified Endograft With Triple Inner Branches for Extensive Aortic Arch Aneurysm
Authors: Zhang Yu , Shen Jiayu , Yang Peng , Hu Jia
Published: November 2021

Purpose:

The purpose of this case report was to demonstrate the feasibility of a physician-modified endograft (PMEG) with 3 inner branches for extensive aortic arch aneurysm.

Case Report:

A 69-year-old male presented with extensive aortic arch aneurysm involving all supra-aortic vessels. An Ankura thoracic stent graft was modified with 3 inner branches fashioned of Viabahn endoprostheses. The procedure was technically successful, and the patient was discharged with no complications.

Conclusion:

This back-table modification of the off-the-shelf endograft is an especially attractive option for complex arch pathologies with urgency and deemed too high risk for reopen surgery.
Safety and Efficacy of Intentional Celiac Artery Coverage in Endovascular Management of Thoracoabdominal Aortic Diseases: A Systematic Review and Meta-analysis
Authors: Argyriou Christos , Spiliopoulos Stavros , Katsanos Konstantinos , Papatheodorou Nikolaos , Lazarides Miltos K. , Georgiadis George S.
Published: November 2021

Purpose:

Thoracic endovascular aortic aneurysm repair (TEVAR) has emerged as an attractive alternative option in the treatment of thoracoabdominal aortic aneurysm (TAAA) diseases, reporting lower morbidity and mortality rates compared with open or hybrid repair. A challenging situation arises when the aneurysm involves the celiac artery (CA), precluding a safe distal landing zone. We investigated the safety and efficacy of CA coverage in the treatment of complex TAAA diseases during endovascular management.

Materials and Methods:

A review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The electronic bibliographic sources searched were MEDLINE and SCOPUS databases. Primary outcomes of interest were perioperative and 30-day mortality. Any type of endoleak, mesenteric ischemia, perioperative spinal cord ischemia, and reintervention rates were secondary end points. A random-effects meta-analysis was performed. Summary statistics of event risks were expressed as proportions and 95% confidence interval (CI).

Results:

Ten observational cohort studies published between 2009 and 2020, reporting a total of 175 patients, were eligible for quantitative synthesis. Indications for TEVAR were primary TAAAs in 82% of patients, aortic dissection in 14% of patients, type Ib endoleak after previous endograft deployment in 3% of patients, and penetrating aortic ulcer in 1 patient. Reintervention rate was 9% (95% CI, 4%–20%) and spinal cord ischemia was 7% (95% CI, 4%–-12%). Type II endoleak was the predominant type of endoleak in 10% of patients (95% CI, 4%–22%), followed by type I endoleak in 5% of patients (95% CI, 2%–12%) and type III endoleak in 1% (95% CI, 0%–16%) of patients. Mesenteric ischemia occurred in 6% of patients (95% CI, 3%–10%). Thirty-day mortality was 5% (95% CI, 2%–13%) and the pooled estimate for overall mortality was 21% (95% CI, 14%–31%).

Conclusions:

Celiac artery coverage during TEVAR is a challenging but feasible option for the treatment of TAAA diseases, providing acceptable morbidity and mortality rates. Demonstration of adequate visceral collateral pathways before definitive CA coverage is the sine quo non for the success of the technique.
Similar Midterm Clinical Outcomes and Aortic Remodeling in Bifurcated and Straight Aortic Stent Grafts Used to Treat Isolated Abdominal Aortic Dissection
Authors: Wang Tun , Shu Chang , Li Quan-ming , Li Ming , Li Xin , He Hao , Luo Ming-yao , Fang Kun , Dardik Alan , Shi Jing-cheng
Published: November 2021

Purpose:

The optimal treatment for isolated abdominal aortic dissection (IAAD) is currently unknown. We compared the effects of straight and bifurcated aortic stent grafts on postoperative aortic remodeling in patients with IAAD.

Materials and Methods:

From February 2012 to December 2019, 57 patients with IAAD were treated using endovascular methods, including either a bifurcated or a straight aortic stent graft. The clinical features, risk factors, computed tomography angiograms, midterm follow-up results, and aortic remodeling of these patients were reviewed and analyzed.

Results:

In total, 44 (77%) patients were treated with a bifurcated graft and 13 (23%) patients were treated with a straight graft. Patients treated with straight grafts had fewer common iliac arteries involved (38% vs 73%, p=0.023), the dissection length was shorter (76.3 ± 40.0 vs 116.2 ± 56.7 mm, p=0.011), and the preoperative aortic diameter (26.0 ± 5.6 vs 35.2 ± 12.1 mm) and the false lumen diameter (13.1 ± 5.2 vs 21.2 ± 11.3 mm) were smaller. During the procedure, there were 3 (5.3%) type I endoleaks, 1 (1.8%) surgical conversion and 1 (1.8%) partial renal artery coverage without perioperative mortality. Patients with straight grafts had shorter operative time (96.5 ± 24.4 vs 144.2 ± 49.0 minutes, p<0.0001). The median follow-up duration was 37.6 ± 21.0 (range = 3–89) months with 1 (1.8%) aortic-related death. Type A aortic dissection occurred in 1 (1.8%) patient. New descending aortic dissection occurred in 3 (5.3%) patients, and 1 patient advanced to type A aortic dissection 3 months later. Two (3.5%) patients had limb occlusion. There was no significant difference in aortic remodeling, survival, and freedom from all adverse events between the 2 treatment strategies.

Conclusions:

Endovascular treatment provides a safe, minimally invasive treatment for IAAD in midterm follow-up. Compression of the true lumen at the aortic bifurcation is the main concern after treatment with a bifurcated graft. Straight grafts are an excellent alternative for some patients, with the benefit of reduced procedural time, effective aortic remodeling, and excellent clinical prognosis. More experience is needed to offer clear recommendations for making treatment decisions as well as determine long-term effectiveness and durability.
Low-Dose Valganciclovir Prophylaxis Is Safe and Cost-Saving in CMV-Seropositive Kidney Transplant Recipients
Authors: Shi Yiyun , Lerner Alexis Hope , Rogers Ralph , Vieira Kendra , Merhi Basma , Mecadon Krista , Osband Adena J. , Bayliss George , Gohh Reginald , Morrissey Paul , Farmakiotis Dimitrios
Published: November 2021

Introduction: Observational studies suggest that low-dose valganciclovir prophylaxis (450 mg daily for normal renal function) is as effective as and perhaps safer than standard-dose valganciclovir (900 mg daily) in preventing CMV infection among kidney transplant recipients. However, this practice is not supported by current guidelines due to concerns for breakthrough infection from resistant CMV, mainly in high-risk CMV donor-seropositive/recipient-seronegative kidney transplant recipients. Standard-dose valganciclovir is costly and possibly associated with higher incidence of neutropenia and BKV DNAemia. Our institution adopted low-dose valganciclovir prophylaxis for intermediate-risk (seropositive) kidney transplant recipients in January 2018. Research Question: To analyze the efficacy (CMV DNAemia), safety (BK virus DNAemia, neutropenia, graft loss, and death), and cost savings associated with this change. Design: We retrospectively compared the above outcomes between CMV-seropositive kidney transplant recipients who received low-dose and standard-dose valganciclovir, transplanted within our institution, between 1/19/2014 and 7/15/2019, using propensity score-adjusted competing risk analyses. We also compared cost estimates between the two dosing regimens, for 3 months of prophylaxis, and for different percentage of patient-weeks with normal renal function, using the current average wholesale price of valganciclovir. Results: We studied 179 CMV-seropositive kidney transplant recipients, of whom 55 received low-dose and 124 standard-dose valganciclovir. The majority received nonlymphocyte depleting induction (basiliximab). Low-dose valganciclovir was at least as effective and safe as, and more cost-saving than standard-dose valganciclovir. Conclusion: This single-center study contributes to mounting evidence for future guidelines to be adjusted in favor of low-dose valganciclovir prophylaxis in CMV-seropositive kidney transplant recipients.
A Call to the Front: Occupational Therapy Practice in Addressing School Bullying
Authors: Njelesani Janet , Faulkner Aisha , Schweitzer Beth , Jeon Hayden
Published: November 2021

Students with disabilities are more likely to be bullied at school than nondisabled students. This study aimed to understand occupational therapists’ practices and roles in addressing bullying against students with disabilities. An electronic survey was distributed in the United States to school-based occupational therapists to collect information on roles, practices, and barriers in addressing bullying. Data were analyzed using inferential statistics, frequencies, percentages, and content analysis. A total of 151 occupational therapists participated. The results illuminated critical gaps in occupational therapy practice. The majority of occupational therapists see or hear of bullying but do not address it. They reported the lack of evidence and interventions to draw upon and time due to caseload as key barriers. Occupational therapists can contribute to anti-bullying practices as a member of the interprofessional team, bringing in strategies and interventions from occupational therapy to create safer environments for all students.
Canadian French Translation and Preliminary Validation of the Conformity to Masculine Norms Inventory: A Pilot Study
Authors: Jbilou Jalila , Levesque Natasha , Sonier René-Pierre , Tully Phillip J. , Pinette-Drapeau Iza , Sonier Véronique , Charbonneau Andréanne , Greenman Paul S. , Grenier Jean , Chomienne Marie-Hélène
Published: November 2021

Conformity to masculine norms has been linked to poor mental and physical health outcomes. Its valid assessment among subgroups of the population is therefore a crucial step in the investigation of intercultural variability in the enactment of masculinity, as well as its causes, costs, and benefits. The present pilot study aimed to adapt and conduct a preliminary validation of a French version of the Conformity to Masculine Norms Inventory (CMNI-22), a self-report questionnaire designed to assess overall conformity to male gender standards. The French adaptation of the CMNI-22 (CanFr-CMNI-22) was developed using a forward-backward translation process. The data from a sample of 57 Canadian French men (23–81 years old), collected at two time points 2 weeks apart, were then analyzed to investigate the psychometric properties and factor structure of the CanFr-CMNI-22. Findings indicated adequate internal reliability of the global scores and highly satisfactory test–retest reliability. Correlations with the Male Role Norms Inventory-Short Form (MRNI-SF) at both time points also showed strong convergent validity. Overall, the CanFr-CMNI-22 appears to be a reliable and valid instrument to assess conformity to traditional masculine gender norms in French-speaking men from the general population. This study is a key step in a research process aiming to validate the Canadian French version of the CMNI and contributes to enhance inclusive research and clinical care to foster men’s health.
Anxiety and Depression Status and Influencing Factors of MSM in the Post-COVID-19 Epidemic Period: A Cross-Sectional Study in Western China
Authors: Pan Hong , Lin Bing , Shi Guiqian , Ma Yingjie , Zhong Xiaoni
Published: November 2021

This study aimed to explore the psychological status and influencing factors of men who have sex with men (MSM) during the stable period of the COVID-19 epidemic, to provide a reference for the mental health counseling of MSM, and to provide a scientific basis for this group to actively respond to public health emergencies. A cross-sectional survey was conducted on the demographic characteristics, epidemic experiences, risk perception, and COVID-19-related attitudes of MSM in western China, and MSM anxiety and depression were assessed by using the Anxiety Self-Rating Scale and the Center for Epidemiological Studies Depression (CES-D) Scale. The incidences of MSM anxiety and depression in the post-COVID-19 epidemic period are 21.7% and 38.0%, respectively. Logistic regression analysis showed that in terms of anxiety, high controllability of the epidemic (OR = 0.7616) is a protective factor. Thinking that they are more susceptible to COVID-19 (OR = 1.6168) and worrying about another outbreak of the epidemic (OR = 1.4793) are risk factors. In terms of depression, being able to protect themselves from being infected with COVID-19 (OR = 0.6280) is a protective factor. The role of anal sex as “0”/“0.5,” and believing that they are more susceptible to COVID-19 (OR = 1.3408) are risk factors. The sudden outbreak affected the psychological state of MSM and even caused negative feelings of anxiety and depression. These findings suggest that prevention and education should be strengthened, and effective intervention measures should be taken as soon as possible, to improve the mental health of MSM.
‘We Do Not Talk About It’ – Exploring Visual Approaches to Initiate Deeper Conversations About Perinatal Mental Health With Indian Immigrants
Authors: Philip Bridgit , Kemp Lynn , Taylor Christine , Schmied Virginia
Published: November 2021

Exploring constructions of mental health in the perinatal period among Indian immigrants can be challenging. This article describes the use of visual methods, photo elicitation, free listing and pile sorting, as an adjunct to face-to-face interviews to understand the constructions of perinatal mental health among Indian immigrants in Australia. The benefits and challenges of using these methods and modifications made during the research are explained. The modifications resulted in a broader understanding of terminology used by the Indian community. Incorporating visual methods as an adjunct to interviews when discussing perinatal mental health with Indian immigrants is effective and using multiple methods enhances the richness of data.
A meta-analysis of the effects of episodic future thinking on delay discounting
Authors: Ye Jun-yan , Ding Qing-yu , Cui Ji-fang , Liu Zhe , Jia Lu-xia , Qin Xiao-jing , Xu Hua , Wang Ya
Published: November 2021

Delay discounting (DD) refers to the phenomenon in which the subjective value of future rewards is reduced over time. There are individual differences in the DD rate, and increased discounting has been observed in those with various psychiatric disorders. Episodic future thinking (EFT) is the act of vividly imagining events that may happen in the future. Studies have shown that EFT could reduce DD, although inconsistent results have been reported. The aim of this meta-analysis was to clarify the efficacy with which EFT reduces DD and to identify potential moderators. Forty-seven studies (including 63 contrasts) were included in the final analysis. EFT was found to significantly reduce DD (Hedges’ g = 0.52). Moderator analysis showed that positive EFT ( g = 0.64) was more effective in reducing DD than EFT with the valence not specifically mentioned ( g = 0.28) and EFT with neutral or negative valence ( g = –0.03). In addition, several factors related to the control task and DD task were related to the efficacy of EFT to reduce DD. These findings have implications for using EFT to reduce DD in the future.
Reaching Herd Immunity During the SARS-CoV-2 Pandemic: What School Nurses Need to Know
Authors: Barnby Elizabeth , Reynolds Mark , Gordon Jenny
Published: November 2021

The National Association of School Nurses supports pandemic control efforts. School nurses are advocates for their students, caregivers, school staff, teachers, and school administrators. With a clear understanding of how the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus evolves over time and changes transmissibility through mutations, school nurses gain understanding in epidemiologic calculation of herd immunity. To understand why the estimates of herd immunity fluctuate, as often reported in the news, school nurses need to understand how epidemiologist calculate this number. Obtaining herd immunity will protect the most vulnerable in the population. If all countries have access to vaccines and populations choose to receive vaccinations, herd immunity is more likely to be obtained. Equipped with knowledge of how herd immunity is calculated, school nurses are in a position to educate and advocate for the use of vaccines.
The Role of School Connectedness in Supporting the Health and Well-Being of Youth: Recommendations for School Nurses
Authors: McCabe Ellen M. , Davis Caroline , Mandy Lauryn , Wong Cindy
Published: November 2021

The importance of students feeling connected in school cannot be overstated, as this perception is crucial to support their health and well-being. A lack of school connectedness can lead to adverse physical and mental health outcomes, including bully victimization. Numerous factors, including individual, social, and environmental, influence students’ perceived sense of school connectedness. School nurses are well positioned to establish and maintain school connectedness due to their knowledge, accessibility to students, and familiarity with the school environment. This article details the importance of school connectedness and describes the associations between school connectedness, bullying, and mental health. In addition, we offer recommendations geared toward school nurses regarding strengthening school connectedness and promoting a culture of care and inclusivity within school environments, especially salient in the context of the COVID-19 pandemic.
Revisiting Microteaching in Search of Up-to-Date Solutions to Old Problems
Authors: Hama Hawraz Qader , Osam Űlker Vancı
Published: November 2021

In second language teacher education programs microteaching has always been a significant technique to help bridge theory to practice and prepare the trainees for real classroom contexts. The expected benefits from 10 to 15 minute-microteaching sessions are the communication among the trainees and supervisor, collaboration with each other, and reflection on the teaching. However, due to some constraints such as limited time and big class size, these benefits may not be derived easily. Therefore, this study aims to explore how the effect of a designed Internet-based instructional learning environment (hereafter iBILE) was perceived by the participating preservice teachers on developing their communication, collaboration and reflection in microteaching process. In so doing, 52 Kurdish preservice English language teachers were asked to use the iBILE for 6 weeks. Both quantitative and qualitative data were collected from questionnaires, the system analytics, reflection journals, and semi-structured interviews. The results of the data analysis revealed that the designed iBILE has been perceived highly effective in solving the defined microteaching problems by creating unique opportunities for communication, collaboration, and reflection in microteaching process among the preservice teachers.
Paradise in Hell: Mapping Out Ustopian Cartographies in Margaret Atwood’s MaddAddam Trilogy
Authors: Mustafa Wael
Published: November 2021

The paper examines Margaret Atwood’s MaddAddam trilogy from the fertile lens of cartographical studies of space. Initially, it explores the relationship between cartography and Atwood’s literary oeuvre. Then, it draws upon Foucault’s theory of heterotopia to consider its relevance to Atwood’s Ustopia. It seeks to fill in the gap in the critical studies written on Atwood’s ustopian trilogy. The paper explores how Atwood has diegetically constructed ustopian cartographies in which dystopian spaces are permeated with heterotopic locations of utopian resistance. It attempts to elucidate that the diachronic analysis must be complemented by a synchronic analysis of space. It develops the hypothesis that the ustopian cartographies of the spaces occupied by the characters in Atwood’s MaddAddam trilogy have resolved the tension between utopia and dystopia. By theorizing the cartographies of her ustopia, Atwood establishes herself as a literary cartographer.
The influence of Reader’s Theater on High School Students’ English Reading Comprehension-English Learning Anxiety and Learning Styles Perspective
Authors: Lo Chih-Cheng , Lu Shih-Yun , Cheng Dou-Dou
Published: November 2021

The study aimed to investigate the effects of Reader’s Theater on EFL learners’ English reading comprehension. The roles of English learning anxiety and learning styles in the RT instruction were also explored. Mixed methods research was conducted to collect and analyze quantitative and qualitative data. The subjects were 11 graders in a senior high school in New Taipei City. There were 25 students in the experimental group and 26 in the control group, and the total number of students was 51. Experiment group received RT instruction for 16 periods in 16 weeks, while the control group was distributed with the same scripts without RT instruction as outside reading. Reading tests based on scripts were adopted to examine the difference of learners’ reading comprehension with RT instruction intervention. Questionnaires of Foreign Language Classroom Anxiety and learning styles were conducted to realize the correlations among learners. To understand students’ views on RT instruction, 24 subjects from the experimental group received an interview. The results of the study indicated that most students thought RT helped improve their reading comprehension. In addition, most students regarded that RT decreased English learning anxiety. However, among the six stages of RT, Instant Reading was the stage that students felt most anxious because they were worried about others’ opinions. Finally, the study found that RT was a suitable platform for students with different learning styles. However, RT provided less time for students with visual modality to practice and learn best. It was suggested that instructors adopting RT instruction could use more pictures or graphic organizers.
Comparative Evaluation of Palatal Length, Speech Outcome, and Surgical Complications With Use of Von Langenbeck and Bardach 2 Flap Technique for the Repair of Cleft Palate: A Prospective Randomized Study
Authors: Oswal Yash A. , Natarajan Srivalli , Despande Gaurav S. , Patil Neha S.
Published: November 2021

Purpose: Successful closure of cleft palate is no more the sole criteria for determining the success of palatoplasty. Approximating soft palate musculature plays an equally important role. A continuous palate with muscular sling, speech and unhampered maxillary growth are 3 important goals of palatoplasty. The current study compared 2 popular palatoplasty techniques and also focused on other vital secondary parameters which would alter the final outcome of palatoplasty. Methods: Thirty-two primary cleft palate patients with repaired cleft lip ranging from 4 to 30 years were randomly and equally divided into 2 groups. Group A underwent Langenbeck and Group B underwent Bardach palatoplasty. Sommerlad’s Intra-Velar Veloplasty was performed in all patients. The patients were evaluated for certain palatal and cleft measurements, speech, and surgical complications. The study also compared impact of cleft severity on speech and complications. Results: All the patients showed improvement in palatal length and speech. Significant palatal lengthening was achieved by Bardach as compared to Langenbeck palatoplasty ( P = .002). Amongst the various speech parameters so compared Bardach group showed better speech articulation post-operatively ( P = .020). No significant difference was found between the 2 groups in relation to other speech parameters. Total 4 complications were encountered 2 belonging to each group. Conclusion: Hard palate cleft repair technique plays little role as far as speech outcomes are concerned. It was Intravelar Veloplasty which reestablished the velopharyngeal sphincter and improved the quality of speech. Hence restoring the muscular sling of soft palate using radical dissection should be stressed upon by the surgeons besides the closure of cleft. The current study found few confounding factors such as age, cleft width, and Veau’s class which altered the speech outcomes and/or complications of palatoplasty.
Seismic anisotropy of Opalinus Clay: tomographic investigations using the infrastructure of an underground rock laboratory (URL)
Authors: Esefelder Roman , Wawerzinek Britta , Lüth Stefan , Giese Rüdiger , Krawczyk Charlotte M.
Published: November 2021

Seismic anisotropy and attenuation make claystone formations difficult to characterize. On the other hand, in many geotechnical environments, precise knowledge of structure and elastic properties of clay formations is needed. In crystalline and rock salt underground structures, high-resolution seismic tomography and reflection imaging have proven a useful tool for structural and mechanical characterization at the scale of underground infrastructure (several deca- to hundreds of meters). This study investigates the applicability of seismic tomography for the characterization of claystone formations from an underground rock laboratory under challenging on-site conditions including anisotropy, strong attenuation and restricted acquisition geometry. The seismic tomographic survey was part of a pilot experiment in the Opalinus Clay of the Mont Terri Rock Laboratory, using 3-component geophones and rock anchors, which are installed 2 m within the rock on two levels, thus suppressing effects caused by the excavation damage zone. As a source, a pneumatic impact source was used. The survey covers two different facies types (shaly and carbonate-rich sandy), for which the elliptical anisotropy is calculated for direct ray paths by fitting an ellipse to the separated data for each facies. The tomographic inversion was done with a code providing a good grid control and enabling to take the seismic anisotropy into account. A-priori anisotropy can be attributed to the grid points, taking various facies types or other heterogeneities into account. Tomographic results, compared to computations using an isotropic velocity model, show that results are significantly enhanced by considering the anisotropy and demonstrate the ability of the approach to characterize heterogeneities of geological structures between the galleries of the rock laboratory.
DMAG, a novel countermeasure for the treatment of thrombocytopenia
Authors: Lin Jing , Zeng Jing , Liu Sha , Shen Xin , Jiang Nan , Wu Yue-Song , Li Hong , Wang Long , Wu Jian-Ming
Published: November 2021

Background

Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.

Methods

In this study, giemsa staining, phalloidin staining, immunofluorescence and flow cytometry were used to identify the effects of 3,3ʹ-di-O-methylellagic acid 4ʹ-glucoside (DMAG), a natural ellagic acid derived from Sanguisorba officinalis L. (SOL) on megakaryocyte differentiation in HEL cells. Then, thrombocytopenia mice model was constructed by X-ray irradiation to evaluate the therapeutic action of DMAG on thrombocytopenia. Furthermore, the effects of DMAG on platelet function were evaluated by tail bleeding time, platelet aggregation and platelet adhesion assays. Next, network pharmacology approaches were carried out to identify the targets of DMAG. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to elucidate the underling mechanism of DMAG against thrombocytopenia. Finally, molecular docking simulation, molecular dynamics simulation and western blot analysis were used to explore the relationship between DAMG with its targets.

Results

DMAG significantly promoted megakaryocyte differentiation of HEL cells. DMAG administration accelerated platelet recovery and megakaryopoiesis, shortened tail bleeding time, strengthened platelet aggregation and adhesion in thrombocytopenia mice. Network pharmacology revealed that ITGA2B, ITGB3, VWF, PLEK, TLR2, BCL2, BCL2L1 and TNF were the core targets of DMAG. GO and KEGG pathway enrichment analyses suggested that the core targets of DMAG were enriched in PI3K–Akt signaling pathway, hematopoietic cell lineage, ECM-receptor interaction and platelet activation. Molecular docking simulation and molecular dynamics simulation further indicated that ITGA2B, ITGB3, PLEK and TLR2 displayed strong binding ability with DMAG. Finally, western blot analysis evidenced that DMAG up-regulated the expression of ITGA2B, ITGB3, VWF, p-Akt and PLEK.

Conclusion

DMAG plays a critical role in promoting megakaryocytes differentiation and platelets production and might be a promising medicine for the treatment of thrombocytopenia.

Graphical Abstract
Modeling and Experimental Analysis of Roughness Effect on Ultrasonic Nondestructive Evaluation of Micro-crack
Authors: Wang Zhe , Fan Zhichao , Chen Xuedong , Kang Yihua , Cheng Jingwei , Chen Wei
Published: November 2021

A high-precision evaluation of ultrasonic detection sensitivity for a micro-crack can be restricted by a corroded rough surface when the surface microtopography is of the same order of magnitude as the crack depth. In this study, a back-surface micro-crack is considered as a research target. A roughness-modified ultrasonic testing model for micro-cracks is established based on a multi-Gaussian beam model and the principle of phase-screen approximation. The echo signals of micro-cracks and noises corresponding to different rough front surfaces and rough back surfaces are obtained based on a reference reflector signal acquired from a two-dimensional simulation model. Further comparison between the analytical and numerical models shows that the responses of micro-cracks under the effects of different corroded rough surfaces can be accurately predicted. The numerical and analytical results show that the echo signal amplitude of the micro-crack decreases significantly with an increase in roughness, whereas the noise amplitude slightly increases. Moreover, the effect of the rough front surface on the echo signal of the micro-crack is greater than that of the rough back surface. When the root-mean-square (RMS) height of the surface microtopography is less than 15 μm, the two rough surfaces have less influence on the echo signals detected by a focused transducer with a frequency of 5 MHz and diameter of 6 mm. A method for predicting and evaluating the detection accuracy of micro-cracks under different rough surfaces is proposed by combining the theoretical model and a finite element simulation. Then, a series of rough surface samples containing different micro-cracks are fabricated to experimentally validate the evaluation method.
Which is the best transcranial direct current stimulation protocol for migraine prevention? A systematic review and critical appraisal of randomized controlled trials
Authors: Ornello Raffaele , Caponnetto Valeria , Ratti Susanna , D’Aurizio Giulia , Rosignoli Chiara , Pistoia Francesca , Ferrara Michele , Sacco Simona , D’Atri Aurora
Published: November 2021

Background

Transcranial direct current stimulation (tDCS) could counteract the pathophysiological triggers of migraine attacks by modulating cortical excitability. Several pilot randomized controlled trials (RCTs) assessed the efficacy of tDCS for migraine prevention. We reviewed and summarized the state of the art of tDCS protocols for migraine prevention, discussing study results according to the stimulations parameters and patients’ populations.

Main body

We combined the keywords ‘migraine’, ‘headache’, ‘transcranial direct current stimulation’, and ‘tDCS’ and searched Pubmed, Scopus, and Web of Science, from the beginning of indexing to June 22, 2021. We only included RCTs comparing the efficacy of active tDCS with sham tDCS to decrease migraine frequency, intensity, and/or acute drug utilization. The risk of bias of each RCT was assessed by using the RoB-2 tool (Cochrane Collaboration).

Thirteen RCTs (from 2011 to 2021) were included in the review. The included patients ranged from 13 to 135. RCTs included patients with any migraine (n=3), chronic migraine (n=6), episodic migraine (n=3) or menstrual migraine (n=1). Six RCTs used cathodal and five anodal tDCS, while two RCTs compared the efficacy of both cathodal and anodal tDCS with that of sham. In most of the cathodal stimulation trials, the target areas were the occipital regions, with reference on central or supraorbital areas. In anodal RCTs, the anode was usually placed above the motor cortical areas and the cathode on supraorbital areas. All RCTs adopted repeated sessions (from 5 to 28) at variable intervals, while the follow-up length spanned from 1 day up to 12 months. Efficacy results were variable but overall positive. According to the RoB-2 tool, only four of the 13 RCTs had a low risk of bias, while the others presented some concerns.

Conclusions

Both anodal and cathodal tDCS are promising for migraine prevention. However, there is a need for larger and rigorous RCTs and standardized procedures. Additionally, the potential benefits and targeted neurostimulation protocols should be assessed for specific subgroups of patients.
Adsorptive Removal of Copper (II) Ions from Aqueous Solution Using a Magnetite Nano-Adsorbent from Mill Scale Waste: Synthesis, Characterization, Adsorption and Kinetic Modelling Studies
Authors: Sulaiman Syazana , Azis Raba’ah Syahidah , Ismail Ismayadi , Man Hasfalina Che , Yusof Khairul Faezah Muhammad , Abba Muhammad Umar , Katibi Kamil Kayode
Published: November 2021

In this study, magnetite nano-adsorbent (MNA) was extracted from mill scale waste products, synthesized and applied to eliminate Cu2+ from an aqueous solution. Mill scale waste product was ground using conventional milling and impacted using high-energy ball milling (HEBM) for varying 3, 5, and 7 milling hours. In this regard, the prepared MNA was investigated using X-ray diffraction (XRD), high-resolution transmission electron microscope (HRTEM), field emission scanning electron microscopy–energy-dispersive X-ray spectroscopy (FESEM-EDS), UV–Vis spectroscopy, Fourier-transform infrared (FTIR), Brunauer–Emmett–Teller (BET) and zeta potential. The resultant MNA-7 h milling time displayed a crystalline structure with irregular shapes of 11.23 nm, specific surface area of 5.98 m2g−1, saturation magnetization, Ms of 8.35 emug−1, and isoelectric point charge at pH 5.4. The optimum adsorption capacity, qe of 4.42 mg.g−1 for the removal of Cu2+ ions was attained at 120 min of contact time. The experimental data were best fitted to the Temkin isotherm model. A comparison between experimental kinetic studies and the theoretical aspects showed that the pseudo-second-order matched the experimental trends with a correlation coefficient of (R2 > 0.99). Besides, regeneration efficiency of 70.87% was achieved after three cycles of reusability studies. The MNA offers a practical, efficient, low-cost approach to reutilize mill scale waste products and provide ultra-fast separation to remove Cu2+ from water.
Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity
Authors: Rayamajhi Sagar , Wilson Sarah , Aryal Santosh , DeLong Robert
Published: November 2021

FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO4 nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe3+ doxorubicin complex resulting in the formation of FePO4-DOX nanoparticles. FePO4-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe3+ complexation with DOX in FePO4-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO4 NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery.
Frequency of alterations in qSOFA, SIRS, MEWS and NEWS scores during the emergency department stay in infectious patients: a prospective study
Authors: Latten Gideon H. P. , Polak Judith , Merry Audrey H. H. , Muris Jean W. M. , Ter Maaten Jan C. , Olgers Tycho J. , Cals Jochen W. L. , Stassen Patricia M.
Published: November 2021

Background

For emergency department (ED) patients with suspected infection, a vital sign-based clinical rule is often calculated shortly after the patient arrives. The clinical rule score (normal or abnormal) provides information about diagnosis and/or prognosis. Since vital signs vary over time, the clinical rule scores can change as well. In this prospective multicentre study, we investigate how often the scores of four frequently used clinical rules change during the ED stay of patients with suspected infection.

Methods

Adult (≥ 18 years) patients with suspected infection were prospectively included in three Dutch EDs between March 2016 and December 2019. Vital signs were measured in 30-min intervals and the quick Sequential Organ Failure Assessment (qSOFA) score, the Systemic Inflammatory Response Syndrome (SIRS) criteria, the Modified Early Warning Score and the National Early Warning Score (NEWS) score were calculated. Using the established cut-off points, we analysed how often alterations in clinical rule scores occurred (i.e. switched from normal to abnormal or vice versa). In addition, we investigated which vital signs caused most alterations.

Results

We included 1433 patients, of whom a clinical rule score changed once or more in 637 (44.5%) patients. In 6.7–17.5% (depending on the clinical rule) of patients with an initial negative clinical rule score, a positive score occurred later during ED stay. In over half (54.3–65.0%) of patients with an initial positive clinical rule score, the score became negative later on. The respiratory rate caused most (51.2%) alterations.

Conclusion

After ED arrival, alterations in qSOFA, SIRS, MEWS and/or NEWS score are present in almost half of patients with suspected infection. The most contributing vital sign to these alterations was the respiratory rate. One in 6–15 patients displayed an abnormal clinical rule score after a normal initial score. Clinicians should be aware of the frequency of these alterations in clinical rule scores, as clinical rules are widely used for diagnosis and/or prognosis and the optimal moment of assessing them is unknown.