bluuebunny/crossref_metadata_2025 huggingface dataset:
Estratégias de cuidado a pessoas que tentaram suicídio segundo a literatura
Authors: Silva Dayane Rodrigues , Pegoraro Renata Fabiana
Published: October 2023

O suicídio representa um problema de saúde pública e o cuidado desenvolvido com pessoas que tentam suicídio pode ser determinante para evitar a ocorrência de novas tentativas. Este trabalho teve como objetivo identificar as estratégias de cuidado às pessoas que tentam suicídio e mais especificamente seus alcances e limites. Foi realizada uma revisão da literatura a partir de buscas nas bases Google Scholar, Scielo e Pepsic com a palavra-chave “tentativa de suicídio”. Foram selecionados e lidos na íntegra oito artigos publicados entre 2006 e 2017. Destaca-se a importância do acolhimento, ações com a família, trabalho em equipe multiprofissional e encaminhamento para outros serviços da rede. Observam-se dificuldades do trabalho em rede, ausência de diálogo entre as equipes, dificuldades no cuidado de pessoas que tentam suicídio, falta de capacitação e problemas de infraestrutura. Ressalta-se a necessidade da educação permanente em saúde e o oferecimento de suporte psicossocial para os profissionais.
Perfil de homens autores de violência contra as mulheres
Authors: Pinheiro Letycia Maria Santana , Andrade Thais Afonso
Published: October 2023

Este estudo tem como objetivo analisar o perfil dos homens autores de violência contra as mulheres na literatura científica brasileira, intencionando auxiliar no direcionamento de práticas socioeducativas das políticas públicas no enfrentamento desse tipo de violência. O estudo proposto configura uma revisão sistemática realizada por meio dos descritores “violência contra a mulher”, “autor de violência”, “violência por parceiro íntimo” e “violência doméstica contra a mulher”. As bases de dados pesquisadas foram: SciELO, Oasisbr e BVS, compondo a amostra final de 15 artigos. Diante dos estudos que compuseram o estudo, verifica-se características como idade, situação laboral, escolaridade, uso de álcool e outras drogas, além de histórico de violência familiar. Evidencia-se que o perfil identificado neste artigo apresenta divergências entre pontos das pesquisas nacionais realizadas. Com isso, recomenda-se a formulação de um instrumento que uniformize as investigações acerca da temática, assim como a participação ativa de homens autores de violência nas pesquisas.
ressurreição cristã
Authors: Zanini Rogério
Published: October 2023

O objetivo deste texto é compreender a relevância da ressurreição no âmbito da práxis dos cristãos. Como fato nuclear do cristianismo, a ressurreição de Jesus Cristo configura a totalidade da vida cristã, que abarca o assim na terra (realidade histórica) como no céu (realidade transcendente). Na perspectiva da Cristologia trata-se da relação entre o Jesus ressuscitado e o crucificado. A compreensão da ressurreição cristã, portanto, precisa salvaguardar ambas as dimensões dentro do mistério Pascal de Cristo. O imperativo desta reflexão tem seu ponto de sustentabilidade no Concílio Vaticano II que resgata a dimensão libertadora da ressurreição, imprimindo relevância à práxis cristã. Metodologicamente o estudo contempla três momentos. Tendo por base uma investigação bibliográfica, busca-se realçar os sinais de cruzes e mortes que atualizam hermeneuticamente a cruz do Crucificado Jesus de Nazaré. Em seguida, faz-se uma análise de como a Igreja, através do seu magistério responde às questões da vida, sob a luz dos conceitos de dignidade humana, bem-comum e justiça social, sinais de ressurreição. E, por fim, o estudo propõe uma reflexão de como os eventos, cruz e ressurreição, permitem abrir caminhos de salvação na história, pois não é algo do passado, mas contém uma força de vida que penetrou o mundo. É uma força sem igual (EG 276).
ciências naturais e a fé cristã face às grandes questões do Cosmos e da Criação
Authors: Freire Duarte Alexandre
Published: October 2023

No diálogo (mais ou menos anguloso ou rombudo e com resultados divulgados popularmente de forma assaz descuidada) entre a fé cristã e as ciências naturais há um conjunto de temáticas, relacionadas com a Criação e o Cosmos, que, versando aparentemente sobre realidades idênticas, têm mantido incompreensões injustificadas. Este estudo dá atenção, sucintamente, em cinco dessas temáticas – que percorrem o arco do existente (passado, presente e futuro) – e tenta mostrar o que um crente cristão pode pensar e, se a ocasião se proporcionar, afirmar sustentadamente sobre elas.
Catolicismo popular e libertação
Authors: Aquino Júnior Francisco
Published: October 2023

O catolicismo popular brasileiro é um fenômeno muito mais complexo e ambíguo do que parece. É tanto expressão ideal-simbólico-ritual dos interesses das classes dominantes (alienação), quanto fonte e expressão de esperança e resistência das classes populares (libertação). Pressupondo essa complexidade e ambiguidade, descrita e analisada por vários autores, faremos algumas considerações de ordem histórico-teológicas sobre a versão libertadora do catolicismo popular brasileiro nas décadas de 1960-1980 (assunto). Trata-se de uma abordagem teológica (enfoque), circunscrita ao contexto da Igreja e da teologia da libertação na segunda metade do século XX (contexto). Começaremos retomando o processo de renovação eclesial, desencadeado pelo Concílio Vaticano II (1962-1965) e sua recepção criativa na América Latina a partir da Conferência de Medellín (1968). Falaremos das Comunidades Eclesiais de Base como expressão e fonte por excelência dessa renovação eclesial e de uma versão ou vertente libertadora do catolicismo popular brasileiro. E concluiremos com algumas considerações sobre o catolicismo da libertação no atual contexto socio-eclesial.
Architecture of a distributed software system for procedural planetoid terrain generation
Authors:   Lviv Polytechnic National University, Lviv, Ukraine, Levus Ye. V. , Pustelnyk P. Ya. ,   Lviv Polytechnic National University, Lviv, Ukraine, Moravskyi R. О. ,   Lviv Polytechnic National University, Lviv, Ukraine, Morozov M. Yu. ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: October 2023

The procedural generation of planetoids finds its place in the field of visualization of virtual worlds in video games, movies, and simulation tools. Due to the growing popularity of the application, the requirements for the quality, uniqueness, and scalability of visualization results are increasing, which, in turn, leads to higher requirements for hardware computing resources. This paper proposes a solution for the architecture of a software system for generating planetoid landscapes, based on a combination of a distributed computing system and the use of parallelism based on the Morsel-Driven Query Execution algorithm to overcome hardware limitations. The computing model includes the following components: a main server that supports gRPC connections; worker servers that perform the task of generating planetoid landscapes in parallel; a geospatial database containing vector data of generated planetoids (rivers and reservoirs; geographic regions – biomes, forests, and other road segments) binary storage of three-dimensional models that are superimposed on the generated planetoid landscape; tileset-storage for storing raster data required for a generation; users who use the software system for generating planetoid landscapes to realize their own goals. The use of software agents in the built system allows unifying a set of algorithms as a single entity used for a particular stage of landscape generation and solving the problem of software system extensibility. A distributed messaging system, a broker, is used to send and process requests using a topic per software agent sequence position. The broker utilizes load balancing to deliver landscape generation requests to background workers. To analyze the system’s performance, experiments were conducted with different numbers of background workers (1, 2: 4, 8; 16) and segment sizes of 512, and 2048 pixels. The lowest average time for generating one segment was obtained when the segment size was 512 pixels and the number of segments was 64. The average segment generation time for the above experiments ranged from 0.33 to 9.32 seconds. The integrated architectural solution allowed to reduce the CPU time by 2 to 5 times compared to a system that uses the approach of storing queries in the database. The solution’s efficiency is especially noticeable with large amounts of data, which is determined by the number of segments and their size in pixels.
An improved method for increasing maintainability in terms of serverless architecture application
Authors:   Lviv Polytechnic National University, Lviv, Ukraine, Lakhai V. Y. , Kuzmych O. M. ,   Lviv Polytechnic National University, Lviv, Ukraine, Seniv M. M. ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: October 2023

It has been found that achieving high quality indicators, in particular maintainability [1], is becoming an increasing problem due to the emergence of new technologies, in particular cloud technologies and serverless architecture. Despite this, requirements for the level of ease of support are only growing, and this characteristic of software quality is receiving more and more attention. The numerous tools, methodologies, approaches and methods of software development previously developed by the scientific and engineering communities for its enhancement are insufficiently effective under the existing conditions. It was confirmed that the use of an improved method to increase the convenience of maintenance under the conditions of using a serverless architecture is an urgent necessity. The current state of approaches to increasing the convenience of support was analyzed. As a result, Clean Architecture was chosen as the best existing approach because it inherits the main advantages of competing approaches, provides clearer instructions, and covers a wider range of the development process. Although it provides significant improvements in key maintainability characteristics such as modularity and reusability, there are still other characteristics that need to be considered, such as analyzability. modifiability and testability. The requirements for the improved method were determined and an improved method was developed to increase the convenience of support in the conditions of using a serverless architecture, which satisfies all the previously formulated requirements. In particular, this approach improves work with dependencies, provides a basic structure for components, increases cohesion and reduces coupling of functionality. To evaluate the effectiveness of the created method, two implementations of the same project were developed: based on Clean Architecture and using the improved method. The following maintainability assessment metrics were calculated for them: the Maintainability Index (MI) and its variation, in which only files with an index of less than 100 are taken into account, which we will call the Filtered Maintainability Index FMI. Analyzing the obtained results, it was found that the application of the improved method increases the value of the first metric by 2.1 % and the second by 8.3 %. In this way, the effectiveness of the developed improved method was proven.
Comparative analysis of digital noise generated by additive Fibonacci generators
Authors:   Lviv Polytechnic National University, Lviv, Ukraine, Isakov O. V. , Voitusik S. S. ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: October 2023

Noise generators and pseudorandom number generators (PRNGs) are widely used in the field of information technology, including cybersecurity, for modeling, authorization key generation, and technical protection of information. It has been found that the characteristics of digital noise directly depend on the chosen PRNG algorithm. To determine the quality of the generated noise, special tests are performed, which are primarily applied to the sequence generated by the PRNG. The results of digital noise generated by an PRNG based on four different algorithms of additive Fibonacci generators (AFG) are investigated. The choice of generators of the same type allowed us to analyze the effect of different modifications on the final result of the generated sequences to determine their advantages and disadvantages. Digital signal processing techniques such as frequency, autocorrelation and visual analysis, signal-to-noise ratio, and statistical tests of the NIST package were used to test the noise and generated sequences. Functions for interpreting the obtained data were developed using the MATLAB (DSP System Toolbox) application package and the C programming language for automating NIST tests. It has been found that for effective testing, specific stages and their sequence should be determined: determination of the PRNG period, statistical tests of the NIST package, calculation of the autocorrelation function, and other methods of digital signal processing. It was found that modification of one AFG by using a carry bit (MAFG2) does not improve the results of the generated sequence, unlike the PIKE algorithm, which consists of three AFGs. The MAFG algorithm showed better results during the period testing and at the same time passed NIST tests, unlike the unmodified version. The dependence between the order of the generated sequences and the results of their autocorrelation function was revealed. It is proposed that, in addition to general statistical tests, applied tests should be carried out when choosing or developing a new generator, its effectiveness should be checked under the conditions required by existing standards and requirements. The compliance of the generated digital noise with the requirements for devices for technical protection of information, namely the protection of speech information, has been established.
Gossypiboma Post Cesarean Section: Patient Safety Review
Authors: Darmayasa I Made , Aryana Made Bagus Dwi , Setiawan William Alexander , Antara Gede Eka Rusdi
Published: October 2023

Background: Operations in the pelvic area including cesarean section are often followed by unwanted events in the form of missing surgical instruments. The surgical device that is most often left behind during operations is surgical gauze and is known as a gossypiboma. Surgical gauze is often left in body cavities such as the peritoneum, pelvis, and retroperitoneal spaces. This surgical gauze can remain in the body for days, months, or even years before manifesting clinically. A granulomatous reaction around the surgical gauze may produce exudate followed by the formation of an abscess or fibrotic mass.
Objective: To see the aspect of patient safety in cases of gossypiboma after cesarean section. Methods: Serial report of gossypiboma cases after cesarean section. Results and
Discussion: Three cases of gossyfiboma were reported after cesarean section in Bali in 2017-2018. The diagnosis is made clinically according to complaints, and history of cesarean section and supported by supporting examinations such as BOF (Book-on-Filter), Ultra Sonography, and Computerized Tomography-Scan. Various surgical procedures were performed including sub-total colectomy laparotomy, right hemicolectomy laparotomy, and Hartman procedure laparotomy. All operations went well with good results too. Patient safety approaches and procedures must be carried out strictly to prevent a recurrence.
Conclusion: Reports of three cases of gossypiboma after caesarean section are strongly related to patient safety procedures that are not performed in the operating room.
TDIC E EDUCAÇÃO: desafios e possibilidades na prática pedagógica
Authors: Santos Raquel Moreira dos , Cazuza Erika dos Santos , Aleixo Felipe
Published: October 2023

A Tecnologia Digital de Informação e Comunicação (TDIC) tem desempenhado um papel cada vez mais relevante na sociedade contemporânea, impactando diversos setores, incluindo a educação. Diante disto, o presente estudo objetivou-se mapear, na literatura educacional, desafios e possibilidades do uso da TDIC nas práticas pedagógicas. Trata-se de uma revisão de literatura, que obteve como fonte de pesquisa filtragem em bases de dados. A presente revisão foi dividida em quatro linhas teóricas sendo elas: A Tecnologia Digital de Informação e Comunicação; A integração da TDIC à prática pedagógica; Os desafios e possibilidades que a incorporação da TDIC na educação apresenta; Os principais impactos nos processos de ensino e aprendizagem. A literatura encontrada indica que a incorporação da TDIC na educação apresenta desafios que vão desde a resistência à mudança até questões de infraestrutura. Todavia, as possibilidades e vantagens que a TDIC traz são significativas, oferecendo oportunidades para aprendizagem mais ativa, personalizada e criativa.
Analyzing the measurement of employee performance with human resources scorecard and AHP
Authors: Aisyah Happy Wanda , Samanhudi Didi
Published: October 2023

The Present development of globalization is improving and having an impact on the higher rate of business competition. An Employee is one of the biggest factors for the company development, therefore it is important to assess the employee performance for the company's success. This research aims to analyze the measurement result of the employee performance using the human resource scorecard and analytic hierarchy process. The data was obtained through a questionnaire that was distributed to 25 employees in heavy equipment rental department on PT. Surya Trias Gemilang Surabaya, conducted a data adequacy test, consistency test on the questionnaire, and continued with the AHP weighting. The result showed that the company experienced a decrease in employee performance from a financial perspective which means the company needs special attention from a financial perspective. The company needs to discover the utilization of net income obtained by the company to increase effectiveness for using company assets.
The coffee charm: understanding the relationship between product design dimensions and Willingness to buy from Starbucks
Authors: Ardiansyahmiraja Bobby , Rahayu Siti
Published: October 2023

The growth of the hospitality industry calls for further understanding. The coffee shop sector is a large part of the hospitality industry in Indonesia, considering coffee consumption, exports, and interest. This study uses PLS-SEM to assess the relationship between product design dimensions in coffee shops and the Willingness to buy using Starbucks as a case. A purposive sampling method was utilized to gather respondents that is a customers of Starbucks, and 119 respondents’ data was used to test the hypotheses in this study. This study found that symbolic design significantly affects WOM (β=0.210, p=0.030) and Willingness to buy (β=0.359, p
Job crafting and sustainable work performance: A systematic literature review
Authors: Rózsa Zoltán , Folvarčná Andrea , Holúbek Jakub , Veselá Zuzana
Published: October 2023

Research background: Job crafting based on individual initiative represents a new form of work design, supporting stability in increasing work performance. In many cases, this method proves to be an effective way of increasing employees' work engagement, mainly because of the mediated autonomy in their work performance and the greater meaningfulness that results from it. The basis of job crafting is employee support, which initiates working behavior focused on proactivity in creating and adapting work to the subjective requirements of the employee's individuality. The available literature highlights various approaches that mediate individual topics, with which companies try to stimulate employee behavior, the expected result of which is job crafting, which leads to an increase in work performance.
Purpose of the article: The goal of the study is to identify current research directions in the field of job crafting, specifically in relation to increasing work performance.
Methods: The Web of Science database was used to identify the main directions of research in the relevant literature. Research was directed at peer-reviewed articles published in journals indexed in SSCI as Q1 and Q2. The resulting number of articles was identified based on the PRISMA selection method.
Findings & value added: By analyzing the literary sources, we have identified 4 important research topics that the authors of the scientific articles addressed. The most widespread topic was work engagement and its influence on job crafting. In the second topic, the authors addressed the issue of how job crafting supports the meaningfulness of work. The third research topic that the authors addressed was job crafting as a factor of employee autonomy. The fourth theme identified was the influence of leadership and management support on job-crafting behavior. The paper offers the reader a systematic and clear list of available quality resources that can help them in their personal research related to job crafting and work performance. In addition, the results of our research may be useful for companies trying to improve the work performance of their employees.
Of the Awefull Afterlife of Cats. From the Illustrated Book to the Stage
Authors: Díaz Morillo Ester
Published: October 2023

Old Possum’s Book of Practical Cats
(1939) de T. S. Eliot adquirió mayor popularidad tras ser adaptado a musical por Andrew Lloyd Webber (1981). El entretenimiento popular fue para Eliot una fuente de inspiración, lo que hace especialmente interesante examinar el proceso contrario: ver cómo su poesía ha inspirado otras artes y cómo esta adaptación ha interpretado o transferido el ritmo y sentido del humor de
Practical Cats. Este artículo se centra en cómo el musical Cats de Lloyd Webber está en continuidad con las teorías de Eliot sobre drama, música y baile, especialmente influenciadas por el
music hall.
“Undiverted Hearts”: Domestic Alienation and Moral Integrity in Jane Austen’s Mansfield Park and Henry James’s Washington Square
Authors: Valero Redondo María
Published: October 2023

My aim in this article is to argue that Henry James’s Washington Square (1880) is an unacknowledged reworking of Jane Austen’s Mansfield Park (1814). To this purpose, I have analyzed both narratives as fictions of domestic alienation in which the heroines refuse to allow their individuality to be subdued by; (a) patriarchal authority and parental mismanagement; (b) the interferences and meddlings of their manipulative aunts; or (c) the libertine corruption of their deceitful suitors. Although they have been subjected to coercion and manipulation, Fanny Price and Catherine Sloper rebel against the pressures of parental authority and emerge as the true preservers of moral integrity.
The international order from an Asian perspective: the importance of global understanding
Authors:   Investigador sénior asociado, CIDOB, Golden Seán
Published: October 2023

With the Western order in crisis, the centre of gravity in terms of demographics and global trade has shifted to Asia. But this geopolitical area did not define the current world order nor is there an alternative yet. The non-Western Rest no longer shares a Western perception of geopolitics that thwarts its own development. Growing neonationalism and the prioritisation of domestic policy favours geostrategic rivalry, obstructing cooperation and a constructive international dynamic on every front. Contradictory ways of defining the terms of the debate lead to discrepancies that hinder the resolution of conflicts. From a constructivist approach, it is necessary to deconstruct the discourses on geopolitical power, which have been hijacked by realism. Understanding the underlying political philosophies of the Rest could facilitate a constructive debate on the nature of the emerging world order and how it might be organised.
Understanding the risks associated with wallets, depository services, trading, lending, and borrowing in the crypto space
Authors: Mikhaylov Alexey
Published: October 2023

The crypto space offers numerous opportunities for users to grow their wealth through trading, lending, and borrowing activities. However, these opportunities come with inherent risks that need to be carefully managed to protect your assets and maximize returns. By understanding the risks associated with wallets and depository services, trading, lending, and borrowing, users can make informed decisions and enjoy the benefits of the rapidly evolving world of cryptocurrencies. This review paper analyses 43 papers for the period of 2019–2023 and proposes recommendations for policy makers. The results confirm that international regulators expect national authorities to implement a regulatory framework for digital assets comparable to those that already exist for traditional finance. For national authorities, this means having and using the powers, tools and resources to regulate and oversee a growing market. Authorities should cooperate and coordinate with each other, at the national and international levels, to encourage consistency and knowledge sharing. Market operators (exchanges), service providers, exchanges and wallets, create effective risk management structures, as well as reliable mechanisms for collecting, storing, protecting and reporting data.
Reforming China’s healthcare management in the wake of COVID-19: A psychological well-being perspective
Authors: Jiang Leilei , Wider Walton , Tanucan Jem Cloyd M. , Bien Jonna Karla C.
Published: October 2023

The COVID-19 pandemic has led to a reevaluation of global health capabilities, highlighting the importance of prioritizing the welfare of frontline healthcare workers. These individuals encountered difficult circumstances on a global scale, including longer work hours, heightened risk of virus exposure, and substantial strain on their mental and physical well-being. Healthcare professionals in China faced similar challenges. This article discusses systemic issues that have been exacerbated by the pandemic and argues for a sustained emphasis on the well-being of healthcare workers, rather than solely addressing it as a crisis response. Given the increasing likelihood of future global pandemics, it is crucial to emphasize the establishment of a durable support system that can enhance resilience and crisis management capabilities. This study examines the systemic challenges of the Chinese healthcare system, with a particular focus on the difficulties encountered during the pandemic. We advocate for a paradigm shift that acknowledges healthcare workers as essential stakeholders within healthcare systems. The objective is to encourage a worldwide conversation for implementing initiatives that transcend national boundaries, with the goal of consistently incorporating a culture of compassion and assistance into healthcare systems. We propose the implementation of a comprehensive support system that encompasses all facets of healthcare, going beyond the mere management of crises. Our vision is for health systems to prioritize the well-being of healthcare workers and the communities they serve, with a focus on resilience.
Implantable-cardioverter-defibrillator after ST-elevation myocardial infarction: when and how frequently is it implanted and what is the rate of appropriate interventions? Insight from Trieste registry
Authors: Pezzato Andrea , Fabris Enrico , Gregorio Caterina , Cittar Marco , Contessi Stefano , Carriere Cosimo , Lardieri Gerardina , Zecchin Massimo , Perkan Andrea , Sinagra Gianfranco
Published: October 2023

Background

There are limited data on implantable-cardioverter-defibrillator (ICD) implantation after ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Therefore, we evaluated when and how frequently an ICD is implanted after pPCI, the rate of appropriate ICD interventions, and predictors of ICD implantation.

Methods

We analyzed STEMI patients treated with pPCI at the University Hospital of Trieste, Italy, between January 2010 and December 2019. We cross-matched patients’ data with those present in the Trieste ICD registry.

Results

Among 1805 consecutive patients treated with pPCI, 3.6% underwent ICD implantation during a median follow-up of 6.7 [interquartile range (IQR) 4.3–9.2] years. At 12 months, the mean number of ICD implantations was 2.3/100 patients [95% confidence interval (95% CI) 1.7–3.1] and remained stable over time (at 24 months: 2.5/100 patients, 95% CI 2.0–3.5 and at 36 months: 2.6/100 patients, 95% CI 2.3–3.8); 83.1% of ICDs were implanted for primary prevention, and more than half (55%) were implanted in patients with ejection fraction more than 35% at the moment of STEMI discharge. The rate of appropriate ICD interventions was 16.9% at a median follow-up of 5.7 years (IQR 3.3–8.3 years) after ICD implantation. At 12 months, the mean number of appropriate ICD interventions was 5/100 patients and 7/100 patients after 24 months. In patients with ejection fraction more than 35% at STEMI discharge (median ejection fraction 43%; IQR 40–48), independent predictors of ICD implantation were male sex, anterior STEMI and troponin peak more than 100 000 ng/dl.

Conclusion

The rate of ICD implantations after pPCI is low; however, the rate of appropriate ICD interventions is high. A relevant subgroup of patients received ICD implantations at follow-up despite a nonsevere ejection fraction at discharge after STEMI. Among these patients, those with high troponin release deserve strict follow-up and full optimal medical treatment.
The use of role-playing in German as a foreign language class in Albania
Authors: Shahinaj Livia
Published: October 2023

Role playing in German as a foreign language is very important in understanding its context. This manuscript consists of the following sections:

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Definition of role play;

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How does it help students of German language?

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What does role play offer to students?

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Do we find role play exercises in books?

Regarding these issues a google form survey was distributed to students of German language. In this context main purpose of this survey is to check whether the role play exercises are part of the lesson, unit and therefore the learning process.
Cinacalcet therapy in a child with novel homozygous CASR p.Glu353Lys mutation causing familial hypocalciuric hypercalcemia type 1: case report and review of the literature
Authors: Koca Serkan Bilge
Published: October 2023

Background. Familial hypocalciuric hypercalcemia (FHH) is one of the conditions that should be considered in the differential diagnosis of hypercalcemia and normo-hypophosphatemia in childhood. Heterozygous Calcium-sensing receptor (CASR) gene mutations cause FHH, and homozygous CASR gene mutations cause neonatal severe primary hyperparathyroidism (NSHPT). Cinacalcet is an allosteric modulator of Calciumsensing receptor (CaSR), and has been used in the treatment of these clinical entities in recent years.
Case. A 26-month-old boy was examined for a recurrent rash. During the evaluation, hypercalcemia (13.3 mg/ dL), hypophosphatemia (2.3 mg/dL) and inappropriately normal PTH level (67 pg/mL) were observed. Neck and renal ultrasonography were normal. The parathyroid scintigraphy was unremarkable. The patient`s family members were also evaluated, and hypocalciuria (fractional excretion of calcium were 0.01%, 0.04% on two separate tests) was detected concurrently with the patient`s hypercalcemia. The mother`s serum calcium was 10.2 mg/dL, the father`s was 10.6 mg/dL, and the brother`s was 12.8 mg/dL. CASR gene sequencing showed a novel homozygous mutation in exon 4 (c.1057G > A), which had generated a substitution of the amino acid glutamate to lysine at codon 353 (p.Glu353Lys). This mutation was homozygous in the children and heterozygous in the parents. Fluid hydration, furosemide, oral phosphorus, prednisolone, pamidronate and cinacalcet treatments were used in the management of hypercalcemia of the proband. A longer and more effective control was achieved with cinacalcet treatment.
Conclusions. FHH can be seen in heterozygous as well as homozygous CASR gene mutations. Different clinical findings may occur in different individuals from the same family. Cinacalcet therapy can be used successfully in the treatment of individuals with FHH.
A rare complication of IgA vasculitis: renal and intestinal ischemia successfully treated with plasmapheresis
Authors: Türkmen Şeyma , Taşar Sevinç , Güzel Meryem , Sönmez Hafize Emine , Çakan Mustafa , Sözeri Betül
Published: October 2023

Background. IgA vasculitis (IgAV) is a multisystemic small vessel vasculitis and is the most common vasculitis in childhood. The characteristic findings of IgAV are palpable purpuric rash, abdominal pain, arthralgia or arthritis, and hematuria. Ischemic complications are very rare in IgAV. Thrombotic complications can be observed after a COVID-19 infection. Also in the presence of familial Mediterranean fever, IgAV may have an atypical or more severe course.
Case. We present a case of IgAV complicated with renal infarction and intestinal ischemia. There was no recent or distant history of COVID-19 in the patient or family members, but the patient`s COVID-19 antibody was positive. In addition, MEFV gene analysis of the patient showed homozygous M694V mutation. The patient did not respond to enoxaparin, pulse methylprednisolone, intravenous immunoglobulin (IVIG), iloprost, and cyclophosphamide treatments. She was successfully treated with six sessions of plasmapheresis.
Conclusions. Plasmapheresis seems to be an effective treatment option in IgAV-related ischemic findings that do not respond to intensive immunosuppressive therapy.
The effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: a prospective case-control study
Authors: Çakmaklı Hasan Fatih , Gökçe Hafize , Söylemez Esma , Topçuoğlu Pervin , Kayaaltı Zeliha , İleri Dilber Talia
Published: October 2023

Background. Every year, thousands of donors are exposed to granulocyte-colony stimulating factor (G-CSF) for stem cell mobilization in hematopoietic stem cell transplantations (HSCT). Previous studies about the genotoxicity of G-CSF were inconclusive. In this study, the genotoxic effects of G-CSF in peripheral blood stem cell (PBSC) donors were evaluated prospectively by using three different validated and reliable methods for the first time in the literature to the best of our knowledge.
Methods. Donors of PBSC transplantation (n=36), who received G-CSF were evaluated for genotoxicity by micronucleus test (MNT), nuclear division index (NDI), and comet assay (CA). Genotoxic effects are expected to cause an increase in MNT and CA values and decrease in NDI. Blood samples were collected at three timepoints (TP): before starting G-CSF (TP1), after G-CSF for five days (TP2), and one month after the last dose (TP3). Sixteen controls were included for baseline comparison of genotoxicity tests. CD34 cell counts and hemograms were also analyzed.
Results. MNT and CA parameters; comet and tail length, tail DNA%, and tail moment, showed no change in time whereas another CA parameter, Olive`s tail moment (OTM) was increased significantly at TP3 compared to both baseline and TP2 (p=0.002 and p=0.017, respectively). Nuclear division index decreased significantly at TP2 (p < 0.001), then increased above baseline at TP3 (p=0.004). Baseline comparison with controls showed higher MN frequency in donors without statistical significance (p=0.059). Whereas, CA results were significantly higher in controls. CD34 cell count showed moderate positive correlation with white blood cell count at TP2 (Pearson R=0.495, p=0.004).
Conclusions. Our results showed the genotoxic effect of G-CSF in healthy donors, in two of the three tests performed, short-term effect in NDI, and long-lasting effect in OTM. So, this study provides novel information for the debate about the genotoxicity of G-CSF and supports the need for further studies with a larger sample size and longer follow-up.
Challenges in Management of Oral Cancer Cases Among the Indigenous Nicobarese Tribe of the Remote Car Nicobar Island, India during COVID19 Pandemic-A Case Report Series
Authors:   ICMR-Regional Medical Research Centre, Post Bag No. 13, Dollygunj, Port Blair 744101, Andaman And Nicobar Islands, India, Parvez Rehnuma
Published: October 2023

The prognosis of oral cancer highly depends on early diagnosis and access to proper treatment measures.
How Development of a Healthcare Standard of Preparedness Can Save Community Medicine: A Conflict Analysis and Resolution Perspective
Authors:   Ph.D. Candidate, Conflict Analysis And Resolution Department, Nova Southeastern University, Ft. Lauderdale, Florida, United States, Connor Courtney Lee
Published: October 2023

U.S. hospitals and health systems are facing a trifecta of crises in the aftermath of the Covid-19 pandemic – financial peril, reduction in provision of healthcare, and a rise in litigation
Sudden Cardiac Deaths Before - After Covid -19 Pandemia and Spike Protein Derivates Uses
Authors:   IMA Marijnskaya Academy, Professorship General Toxicology, Applied And Industrial Chemistry Branch, Italy, M Luisetto
Published: October 2023

Aim of this work is to observe some interesting phenomena involving pre and post pandemia cardiac sudden deaths epidemiology and after the mass vaccination campaign.
Impact of Salt Concentrations and Storage Temperatures on Microbial Safety of Paddlefish Roe
Authors:   Department Of Animal Science, Oklahoma State University, Stillwater, OK, 74078, United States, Jadeja Ravi
Published: October 2023

In this study, authors have investigated the impacts of salt concentrations and storage temperatures on the microbial safety of paddlefish roe.
Refrigeration Potential of Fruit Trees Introduced in West Georgia
Authors:   Batumi Shota Rustaveli State University, N35 Ninoshvili Street, Batumi, 6010, Georgia, I Gaprindashvili
Published: October 2023

The paper explores the challenges related to the development of agricultural technology services in the humid subtropical region of Georgia.
Từ năng lực ngôn ngữ đến năng lực liên văn hóa
Authors: Quang Nguyễn
Published: October 2023

Tóm tắt: Bài viết này trình bày một cách có phê phán các loại năng lực ngôn ngữ, dụng học, giao tiếp và (giao tiếp) liên văn hóa với nhận định rằng các loại năng lực đó được đặt trong các chu cảnh khác nhau của quan tâm học thuật và nhu cầu xã hội.
Từ khóa: Năng lực, ngôn ngữ, dụng học, giao tiếp, liên văn hóa.
TEACHER’S CHANGES AND CHALLENGES IN CLIL IMPLEMENTATION
Authors: Thi Thu Hien Tran
Published: October 2023

This study aims at finding out high school English teachers’ changes and challenges in content and language integrated learning in Vietnam. Survey questionnaires and in-depth interviews have been chosen to collect data for the study. The results show that teachers have made encouraging changes in lesson planning, material development, lesson delivery and assessment. The challenges encountered by the teachers involve the subject knowledge, teachers’ time and effort allowances, learners’ motivation and supporting policies. The results of the study can be considered an informative source of reference for future CLIL implementation at schools across our country.
VALIDATION OF A TOOL TO MEASURE THE LEVEL OF SCHOOL-UNIVERSITY PARTNERSHIP
Authors: Thuy Hong Cao , Thi Lan Anh Tran
Published: October 2023

This study aims at developing and validating an audit tool that could be used to assess school-university partnerships. Specifically, the study followed four steps of (i) evaluating and modifying contents and items of the original tool, (ii) qualitatively assessing content validity of the revised scale basing on expert ratings, and revising the scale accordingly, (iii) conducting cognitive interviews with potential participants, and making further revision, and (iv) quantitatively evaluating the validity and reliability of the audit tool based on data collected from 463 participants, and finalizing the tool. In the end, an audit tool consisting of 36 questions that fit into two scales (i.e., “Shared goals and values” and “Partnership operations and management”) was confirmed. The study also discussed potential uses of the tool for both currently working partnerships and newly formed partnerships; and at different levels.
Biochemical composition, oil profiling and elemental analysis of different cumin (Cuminum cyminum L) genotypes
Authors: Gamit N S , Litoriya N S , Thounaojam A S , Patel P K
Published: October 2023

Cumin (Cuminum cyminum L.) is an annual plant of the family Apiaceae and the genus Cuminum has a single species Cyminum, native from the east Mediterranean to east India. In India, Gujarat and Rajasthan are the major producing states. After black pepper, cumin is the second most popular spice in the world. The present research work was carried out to study the nutritional quality parameters, oil profiling and element composition of fifteen cumin genotypes. The results showed that the moisture content was found to vary from 6.22 to 8.15 %. The carbohydrate content was higher in Kushalpura-1 (46.14 %), while the crude protein was highest in Indawar followed by GC-2 and Merta-2. Total protein content was highest in Lampolai (18.24 %) and lowest in GC-2 (11.36 %). In Lamba Jatan, highest content of non-reducing sugars (8.35 %) and total soluble sugars (9.11 %) were observed. Reducing sugars was detected in the range of 0.72 – 1.53 %. Highest amount of total free amino acids and crude fiber were found in Gawardi and Kushalpura-1, respectively. The total oil (20.27 %) and volatile oil (3.99 %) content were highest in GC-4. The petroselinic acid and linoleic acid were observed as primary fatty acids in all tested genotypes. However, Lampolai, Merta-1, GC-2 and GC-4 were good sources of both fatty acids among all the genotypes. The elemental analysis showed that the GC-2 has a high overall amount of macronutrients, while micronutrients was highest in Piplon-5.
Exploring the therapeutic potential of volatile bioactive compounds from different parts of Tinospora cordifolia: a gas chromatography-mass spectrometry (GC-MS) study
Authors: Akhilraj B C , Suresh J , Rajamani K , Kumar M , Gnanam R
Published: October 2023

Chemicals utilised in the pharmaceutical business can be found in large quantities in medicinal plants. Crude plant herbal extracts are frequently utilised because they combine a variety of secondary metabolites or phytochemical elements with significant therapeutic potential. The main objective of this research was to identify the medicinally significant phytoconstituents from different economic parts of Tinospora cordifolia employing GC-MS. The stem, leaf, and root, respectively, had a total of 93, 74, and 53 peaks, which translates to a sizable number of phytocompounds with therapeutic value. Our results show that oleic acid, columbin, 10E,12Z-octadecadienoic acid, 9- octadecenoic acid (Z), 2, 3 - dihydroxypropyl ester, n-hexadecanoic acid, and 9,12,15-octadeca trieno were found in various parts of T. cordifolia. The results provide credence to the use of Tinospora cordifolia in conventional medical practice for a range of ailments.
Exploring the impact of using Chat-GPT on student learning outcomes in technology learning: The comprehensive experiment
Authors: Hakiki Muhammad , Fadli Radinal , Samala Agariadne Dwinggo , Fricticarani Ade , Dayurni Popi , Rahmadani Kurniati , Astiti Ayu Dewi , Sabir Arisman
Published: October 2023

This experimental study investigates the impact of integrating Chat GPT (Generative Pre-trained Transformer) on student learning outcomes in technology education at Universitas Muhammadiyah Muara Bungo. The research involves an experimental group using Chat GPT and a control group with conventional methods. Data from 31 participants in each group were collected, assessing learning outcomes through final test scores. Analyzing the results with a t-test, the experimental group displayed significantly higher achievements than the control group, highlighting the positive effect of incorporating GPT Chat into educational technology. The study illuminates the potential of AI-powered chatbots like Chat GPT to enhance student learning outcomes. Further exploration is required to gauge its adaptability across diverse educational contexts for more enhanced learning results. T-test results, conducted at a 95% confidence level with α 0.05, and degrees of freedom dk = n1 + n2 - 2 = 60, showed tcount of 5.424 against ttable of 2.000, firmly establishing tcount > ttable (5.424 > 2.000). Consequently, the null hypothesis (H0) proposing no significant impact of Chat GPT utilization is refuted. Conversely, the alternative hypothesis (H1), signifying a significant influence from Chat GPT usage, is upheld, affirming its substantial role in students' technological education.
Modeling of Uncertainty Propagation for Transient Heat Rejection Problems
Authors: Panasyuk George Y. , Yerkes Kirk L.
Published: October 2023

Generic plate and experiment-related high-fidelity models to study uncertainty propagation and transient processes for heat rejection problems are developed. The stochastic Biot numbers on the top and bottom surfaces of the plate, [Formula: see text] and [Formula: see text], and stochastic dimensionless input parameters, describing initial and convection boundary conditions, are introduced to define temperature variation in the modeled systems. The resulting uncertainty amplitude demonstrates a varying time evolution across a wide range of mean values of the input parameters. Depending on which input parameters are stochastic, the uncertainty may increase or decrease over time, or remain small for a given time interval in the case of the plate model. For small [Formula: see text], dimensionless characteristic time for a temperature variation curve to approach its steady state is [Formula: see text] and large. An extremum in a temperature variation curve may appear when the Biot numbers are unequal and disappears if [Formula: see text]. Results are nonsymmetric with respect to interchanging [Formula: see text] and [Formula: see text]. Despite the difference in shape, the temperature variation profile over a specific region in the experimental test section numerically described by the high-fidelity model is close to the corresponding results provided by the plate model for the same Biot numbers, convection boundary, and initial conditions.