bluuebunny/crossref_metadata_2025 huggingface dataset:
From the Guest Editor
Authors: Button Le
Published: January 2025

The theme of this issue of the OLA Quarterly, “Collections: New Challenges, New Solutions,” was chosen to reflect the tension between an ever-changing library landscape and the ongoing obstacles that continue to affect the ways in which library collections are built, managed, and marketed. In many ways, library work related to collections looks significantly different today than it did even in the very recent past. Whether it’s responding to record-high levels of book challenges or making collections decisions against a backdrop of rapidly evolving information needs, library workers have been presented with a number of new challenges in their efforts to connect the communities they serve with resources that inform, entertain, and inspire. In spite of these developments, there are some areas of concern related to collections that remain evergreen. These include making impactful use of limited resources, working to provide equitable access to communities that have been historically underserved, and staying up to date on trends in the publishing industry and in the broader field of librarianship. The articles in this issue address these ideas and more, and showcase the creativity and innovation of the people working in Oregon's libraries.
Orbis Cascade Alliance
Authors: Moxley Emily
Published: January 2025

In the face of record-breaking book challenges and loud cries for book banning and removals, primarily aimed at LGBTQ+ and BIPOC stories, voices, and books, attention to these topics is paramount.  In response, this year the Diversity, Equity, and Inclusion (DEI) Standing Group from the Orbis Cascade Alliance, a library consortium serving academic libraries in the Pacific Northwest, hosted four trainings centered on LGBTQ+ voices and representation within the academic library sphere.
Study of spatio-temporal evolution of land use using remote sensing tools; case study the City of Ali Mendjeli Constantine (Algeria)
Authors: Lakhdar Ammar , Haouari Souad , Ferhad Toufik , Metrani Meriem , Baadeche Mohamed
Published: January 2025

Change detection is an image processing used to quantify spatial and temporal change based on comparison of land use maps produced from satellite images of the same area of interest for different dates. The aim of our work is to show the importance of remote sensing tools for the long-term monitoring of urban changes and to identify and quantify the spatial and temporal evolution of land use in the Ali Mendjeli New City during 37 years. By applying a change detection technique based on the supervised Maximum Likelihood classification using Landsat images for the years 1985, 2006, 2015 and 2022, the obtained results showed that there is a significant urban fragmentation at the expense of other soil units, especially the bare soil with an important change rate between 1985 and 2006.
Two-dimensional free surface flow through solid walls with surface tension eﬀects
Authors: Gasmi Abdelkader , Guellati Zineb
Published: January 2025

We examine the two-dimensional, steady, and irrotational flow of an inviscid and incompressible fluid emerging from certain cases of flow through solid walls. Surface tension (T) is considered, while gravitational effects are neglected. This problem is complicated by the non-linear boundary condition imposed by the Bernoulli equation on the free surface, which presents challenges when adapting numerical methods used by many researchers. We employ a series truncation method for numerical solution. We computed solutions for various values of the angle (β) between the walls AB and the horizontal, the length of the vertical wall BC, and different Weber numbers. For determining the shape of the free surface, most of the calculations were performed for N=50. We were able to find approximate solutions for To validate our results, they were compared with studies using other numerical methods and  in special cases of the angle β, compared with the exact solution in the limit of .
Bidimensional modelling of pentacene TGTC OTFT
Authors: Abdeslam Nora Amele , Yagoub Mustapha Cherif Edine , Arab Louiza , Lehraki Nadia
Published: January 2025

Modern electronics has been shifting these two last decades significantly towards organic materials based on their specific electroactivity, a small molecules Pentacene (C14H22) is widely used as p-type semiconductor channel in thin-film transistors (TFTs) and has high mobility. In this study, a 2-dimensional modelling under Silvaco Software is adopted. The TFT behaves like MOSFET, so a high-k (εr) dielectric material between the gate and organic semiconductor (OSC) helps to control the transfer of charge carriers and increase their accumulation inside the channel leading to estimable OTFT performances. Thus, the Al2O3 shows the best OTFT characteristics and parameters compared to SiO2, PMMA and HFO2. Poly(3-hexylthiophene) (P3HT) It is a p-type organic semiconductor with interesting properties. P3HT based OTFT exhibits a rapid response at low gate voltage compared to that based on Pentacene under the same conditions (length, width, and topology) but its low mobility still limits considerably all its characteristics.
BPSO-SEP: a routing protocol based on binary particle swarm optimization
Authors: Redjimi Kenza , Nebti Salima , Redjimi Mohammed
Published: January 2025

Wireless sensor networks (WSNs) constitute the building block in many applications; their roles being to collect information, to carry out some basic processing on it and to transmit it to remote base stations. However, these elements face several constraints such as the volatile aspect of the radio links, the accessibility of the monitored environment, the limited energy of batteries, etc. Routing is one of the fundamental functions in wireless networks with the main objectives are the optimal management of the network energy and improving its reliability and latency. In this work, the probabilistic principle of the Stable Election Protocol (SEP) algorithm is replaced by the stochastic principle of the Binary Particle Swarm Optimisation (BPSO) algorithm to obtain the optimal cluster heads. The simulation results of the proposed BPSO-SEP protocol outperform those obtained by the Stable Election Protocol (SEP) and Threshold SEP (TSEP) regarding network lifetime, stability period, network scalability and number of packets delivered to the base station.
Influência da família no comportamento alimentar na primeira infância: uma revisão narrativa
Authors: Leite Wagmar de Souza , Viana Ana Flávia da Silva , Vieira Márcia Eliane , Fonseca Marina Dorim , Santos Vitória Isabele Moreira dos , Barros Eunice da Silva
Published: January 2025

Este estudo é uma revisão narrativa sobre a influência da família na formação dos hábitos alimentares na primeira infância. O ambiente familiar é muito importante, pois as práticas alimentares observadas em casa servem como modelo para o comportamento das crianças. Interações como refeições em família, a acessibilidade e a disponibilidade de determinados alimentos têm grande impacto na formação desses hábitos. Em especial, a presença de alimentos saudáveis no ambiente doméstico é um fator determinante para um desenvolvimento e crescimento saudável. Para a elaboração desta revisão narrativa, foram consultadas 16 bases científicas, com dados obtidos em plataformas como PubMed, SciELO e Medline. Conclui-se que práticas alimentares saudáveis no ambiente familiar são essenciais para construir um crescimento e desenvolvimento adequado para as crianças.
Comunidade LGBTQIA+ e o preconceito histórico social: a relação de gênero sob o aspecto sociolinguístico variacionista no contexto educacional
Authors: Araujo Karina de Jesus , Santiago-Almeida Manoel Mourivaldo , Fernandes Paula Torres , Gouveia Rosa Carolina Silva de , Felício Zoraide Magalhães , Santos Josilene Pereira dos , Romualdo Natália Fonte Boa , Crispim Carina Maria da Silva
Published: January 2025

O presente artigo é direcionado à Comunidade LGBTQIA+ e tem como objetivo retratar seu contexto histórico-social por meio de uma revisão bibliográfica e da análise de relatos pessoais sobre a homofobia. Além disso, busca impulsionar reflexões sobre as atitudes preconceituosas enfrentadas por essa comunidade, considerando sua abordagem na disciplina de língua portuguesa no contexto escolar. A pesquisa justifica-se pela relevância de compreender e combater a homofobia e o preconceito histórico-social enfrentado pela Comunidade LGBTQIA+, especialmente no âmbito educacional, onde as práticas pedagógicas podem contribuir para a promoção da inclusão e da diversidade. A metodologia adotada segue uma abordagem qualitativa, envolvendo a coleta de relatos de pessoas pertencentes a esse grupo minoritário e a produção de histórias em quadrinhos (HQs) com a temática LGBTFobia, elaboradas por alunos do Ensino Médio de uma escola pública de Várzea Grande – MT. Os dados obtidos revelaram um contexto histórico marcado por conflitos sociais: de um lado, a luta da Comunidade LGBTQIA+ por aceitação e pela demarcação de seu espaço social; de outro, a resistência do grupo heteronormativo, que manifesta atitudes de não aceitação e comportamentos homofóbicos, muitas vezes geradores de violência. Portanto, as atividades propostas e realizadas pelos alunos promoveram discussões e reflexões valiosas, evidenciando a necessidade de expandir o alcance deste estudo para além dos muros escolares. Ademais, como base teórica, utiliza-se a Sociolinguística Variacionista, dialogando com autores como Pinsky (2009), Scott (1989), Meira (2014), Paniza (2020), Okita (2015), Bortoni-Ricardo (2004), entre outros.
A estética recursiva na composição do romance Cemitério de Pianos, de José Luís Peixoto
Authors: Dorneles Marcos Rogério Heck
Published: January 2025

A recursividade delineada na construção de narrativas literárias serve a vários propósitos compositivos e críticos. Dentre esses desígnios, destacam-se a disposição da obra ficcional em camadas de reverberação e realimentação semântica e diegética; o desdobramento atuacional na performance das personagens em seus segmentos sociais e profissionais; a projeção de processos de reflexibilidade ante recursos narrativos; a amalgamação dos encadeamentos conflitivos; a constituição de uma estética aberta. O romance Cemitério de pianos, de José Luís Peixoto, relata recursivamente o percurso vivencial de três gerações de uma família lusitana no transcorrer do século XX, tendo como núcleo constitutivo o prosseguimento das atividades do ofício da marcenaria e da competição esportiva da maratona. Como propósitos deste artigo, busca-se delinear correlações do proveito das modificações compositivas com o aprofundamento dos debates temáticos, e vislumbrar amplitudes de processos de solidarização da disposição diegética dos eventos ficcionais com meios de compreensão de problemas sociais recorrentes dos grandes centros urbanos, como os apresentados no universo romanesco da obra.  Para apreciar processos técnicos de composição, refletir sobre adversidades episódicas e visualizar críticas sociais dispostas no romance, este trabalho se estabelece pelo diálogo entre os estudos das teorias da narrativa, da literatura comparada e de recepção crítica. Dispõem-se como resultados a corroboração da interface entre reflexibilidade ficcional e aprofundamento temático na estética recursiva; o fortalecimento do diálogo entre segmentos dos estudos literários no processo de exame compositivo; a observação do fluxo comunicativo entre demandas sociais elementares/ e transmissibilidade ficcional do debate sobre mazelas e adversidades basilares.
Aprendizagem da docência por meio de estágios remunerados na educação infantil: reflexões sobre inclusão escolar
Authors: Machado Carla Cristina Lopes , Marcato Daniela Cristina Barros de Souza
Published: January 2025

Este trabalho teve por objetivo discutir sobre a aprendizagem e inserção na carreira docente por meio dos estágios profissionais remunerados no ambiente da Educação Infantil, com enfoque na inclusão escolar de crianças nessa etapa. Para tanto, realizamos uma discussão teórica abordando a complexidade em contribuir com uma educação inclusiva para um professor que está aprendendo/iniciando a carreira, em especial para aqueles que vivenciam esse processo de inserção por meio de estágios profissionais remunerados. Como considerações, identificamos a necessidade de o estágio ser compreendido em uma proposta formativa interessante para a inserção na carreira, mas que não deve ser feito apenas com a finalidade de suprir a demanda profissional de educadores na Educação Infantil. Ele deve visar a aprendizagem da docência nessa etapa e as ações de inclusão devem ser pensadas e planejadas em parceria com o professor regente/titular da turma, em diálogo com professores especialistas da Educação Especial diante das necessidades que o grupo de crianças apresenta.
Manejo do déficit hídrico em plantas de soja via aplicação de microrganismos e bioestimulantes
Authors: Silva Nelmício Furtado da , Cavalcante Wendson Soares da Silva , Martins Neto José Gomes , Cunha Fernando Nobre , Teixeira Marconi Batista , Silva Lígia Campos de Moura , Rosa Márcio , Cabral Juliana Silva Rodrigues , Cabral Filho Fernando Rodrigues
Published: January 2025

Objetivou-se com presente estudo avaliar a resposta de plantas de soja a aplicação de microrganismos e substâncias bioestimulantes em condições de déficit hídrico. Foi utilizado um delineamento inteiramente casualizado (DIC), em esquema fatorial de 4 × 4, sendo 4 tratamentos de sementes (Microrganismos, bioestimulantes, microrganismos + bioestimulantes e testemunha) e 4 níveis de reposição hídrica (25%, 50%, 75% e 100% da Capacidade de campo – CC), com 5 repetições, totalizando 16 tratamentos e 80 unidades experimentais (Vasos). Os tratamentos previstos aplicações de microrganismos receberam uma dose de produtos comerciais no tratamento de sementes contendo os microrganismos (Bacillus aryabhattai, Bacillus subtilis e Trichoderma asperellum). Os tratamentos com aplicações de bioestimulante receberam uma dose de uma formulação de bioestimulante via tratamento de sementes à base de extrato de alga (Ascophyllum nodusum + Kappaphycus alvarezii) + complexo de aminoácidos contendo (Prolina + arginina) na dose de 2 mL kg-1 de semente. A capacidade de retenção de água do solo (Capacidade de campo - CC) foi determinada através da pesagem de todos os vasos com o solo seco e após o encharcamento e posterior drenagem. Foram determinados os índices biométricos, índices de clorofilas e potencial hídrico foliar (ΨW). O uso de microrganismos (Bacillus aryabhattai + Bacillus subtilis + Trichoderma asperellum) associado ao extrato de algas (Ascophyllum nodusum + Kappaphycus alvarezii) + complexo de aminoácidos promoveu incrementos nas variáveis biométricas de diâmetro de caule e área foliar e na variável fisiológica de potencial hídrico.
Carcinossarcoma de Tireoide em um Pitbull: Relato de Caso
Authors: Dias Breno Sérgio Corona , Coser José Felipe Formentini , Ziviani Amanda Thereza Cabaline , Scheild Haide Valeska , Almeida Luiz Claudio da Silva , Souza Arthur Lima , Coppo Rafaela Lima , Vieira Luisa Frasson , Bergmann Lucimara Konflanz , Marco Caroline Jede de , Santos Catiane Prestes dos , Rossoni Júnior Joamyr Victor , Barcelos Rafael Mazioli , Ambrosio Roberta Passamani , Pereira Clairton Marcolongo
Published: January 2025

Tumores de tireoide representam cerca de 2% das neoplasias em cães, sendo mais comuns em animais de meia-idade a idosos. Entre os tipos de neoplasias, os carcinossarcomas, caracterizados por células epiteliais e mesenquimais malignas, são raramente descritos, mas têm um comportamento agressivo e alta capacidade metastática. Este estudo relata um caso de carcinossarcoma de tireoide em uma cadela Pitbull de 13 anos, com histórico de aumento de volume cervical, dispneia e disfagia. Exames de imagem revelaram uma massa expansiva na região cervical e uma neoformação na adrenal esquerda, sem alteração dos níveis de T3 e T4. A histopatologia confirmou uma proliferação maligna com produção de matriz osteoide, e a imunohistoquímica foi positiva para citoqueratina, TTF-1 e PAX-8. Estudos sugerem que carcinossarcomas de tireoide apresentam padrões de metástase similares aos carcinomas, afetando principalmente pulmões e linfonodos regionais, e menos frequentemente outros órgãos. A presença de metástase em carcinomas de tireoide ocorre em 16% a 38% dos casos. Neste caso, optou-se por não intervir na lesão adrenal devido ao risco de comprometimento vascular. O prognóstico de carcinossarcomas de tireoide em cães é considerado reservado a desfavorável, dada a natureza invasiva e metastática desses tumores.
A EDUCAÇÃO AMBIENTAL COMO MISSÃO INSTITUCIONAL DA POLÍCIA MILITAR AMBIENTAL DO PARÁ
Authors: Silva Fernando Alberto Bilóia da , Oliveira Ângela Maria Santos , Pontes Altem Nascimento
Published: January 2025

A Educação Ambiental (EA) preocupa-se com a articulação de interesses de conservação ambiental que inserem em si a dimensão humana, mediante um processo contínuo e permanente, com ações interdisciplinares globalizantes e da instrumentação da educação formal e não-formal, na construção de valores sociais, conhecimentos, habilidades e competências em harmonia com o desenvolvimento sustentável. O presente artigo objetiva analisar as ações de Educação Ambiental não-formal, como missão institucional da Polícia Militar Ambiental do Pará (PMA/PA), por meio do Batalhão de Polícia Ambiental (BPA), nos espaços não escolares, no âmbito da Região Metropolitana de Belém (RMB), desde o ano de 2022 até outubro de 2024. A metodologia empregou a pesquisa bibliográfica e a documental, de abordagem quantitativa, de natureza aplicada, com atributos exploratórios e descritivos sobre os dados das ações de EA realizadas pela Corporação Ambiental, com auxílio estatística descritiva. Os resultados apontam que o BPA desenvolve, há décadas, ações de EA não-formal tanto para entidades públicas e privadas quanto nas escolas de ensino fundamental e médio, utilizando o Parque Estadual do Utinga (PEUt) como laboratório das visitas monitoradas. A pesquisa revelou também que as ações de EA são uma missão institucional da PMA/PA, possibilitando aos educandos a práxis contemplativa e o desenvolvimento da percepção ambiental no convívio com os recursos hídricos, com os ecossistemas e com a biodiversidade em trilhas dialogadas e monitoradas no interior do PEUt. Como proposta interventiva, sugere-se a implementação do Programa de Educação Ambiental, previsto no Plano Estratégico da Polícia Militar do Pará, utilizando o BPA como estratégia-piloto, mediante o trabalho já desenvolvido nas escolas do ensino fundamental e do médio e na comunidade em geral, com vistas a direcionar essas ações com planejamento e sistematização, possibilitando a concretização da EA e sua expansão futura para outros municípios da RMB e de regiões do território paraense.
THE IMPACT OF ECONOMIC INDICATORS ON CONSUMPTION: A NEURAL NETWORK APPROACH
Authors: Santos Felipe Brigagão , Stekel Tardelli Ronan Coelho
Published: January 2025

Economic indicators are fundamental for understanding consumption patterns and sectoral performance, forming the basis for informed decisions in public policy, investment strategies, and business planning. This research employs neural networks to model the complex and nonlinear relationships between economic variables and consumer behavior. A neural network architecture with two dense layers of 64 neurons each and a regression output layer was implemented using TensorFlow and Keras. The models achieved high predictive accuracy, with R² values exceeding 0.90 for most indicators, demonstrating their ability to explain substantial variability in the data. Variations in Mean Absolute Error (MAE) across indicators reflected specific economic characteristics, further confirming the robustness of the methodology. The findings underscore the potential of neural networks to overcome the limitations of traditional econometric models by capturing complex, multivariate interactions. This approach represents a significant advance in forecasting economic variables, enabling the identification of patterns and trends that inform sector-specific strategies. Future research could enhance predictive capabilities by incorporating broader datasets, domain-specific variables, and advanced architectures, fostering hybrid frameworks that balance accuracy with model interpretability for both academic and practical applications in economic analysis.
Collaborative Control Analysis of Dual Arm Robots
Authors: Yang Junwen
Published: January 2025

The collaborative control technology of dual arm systems does play a crucial role in the field of robotics. This technology enables robots to exhibit extremely high efficiency and accuracy in handling complex, dangerous, or delicate tasks by precisely coordinating the movements of two robotic arms. With the shortage of labor and the continuous increase in labor costs, there are more and more fields that require the use of robots, and the quantity is also increasing. For many application scenarios, tasks are complex and varied, and application environments and conditions are also different. Single arm collaborative robots can no longer meet the requirements, and multi arm collaborative robot systems have emerged and become an important field for future development. However, the dual arm robot is a strongly coupled, highly nonlinear, and uncertain system, and its collaborative control problem is a challenging topic. This review provides a detailed summary of the collaborative control methods for dual arm systems, including classic methods such as master-slave control, force/position hybrid control, and impedance control during collaborative handling; Intelligent control methods based on neural networks and fuzzy systems; The progress of reinforcement learning based control methods in robot control. Finally, the future development trends of dual arm systems were discussed.
ED50 and ED95 of Nalbuphine Combined with Ciprofol in Laryngeal Mask Insertion Responses in Day-Patient Hysteroscopic Surgery
Authors: Liu Haicheng , Li Qifei , Chen Yi
Published: January 2025

Objective: This study aimed to determine the effective dose (ED50 and ED95) of ciprofol combined with nalbuphine in inhibiting laryngeal mask insertion responses in day-patients hysteroscopic surgery using a sequential method. Methods: Patients undergoing general anesthesia hysteroscopic in a daytime surgery center were selected. The age of patients ranged from 18 to 60 years, BMI ranged from 18.0 to 28.0 kg/m 2, and ASA classification ranged from gradeⅠto gradeⅡ. Nalbuphine was administered via slow intravenous injection at an initial dose of 0.16 mg/kg, followed by intravenous administration of 0.4 mg/kg ciprofol. The laryngeal mask was inserted when the patient’s eyelash reflex disappeared and the Narcotrend index reached between 50 and 60. A sequential method was employed to establish the nalbuphine dosage: if a positive response occurred during laryngeal mask insertion, the next patient received a dose one gradient higher; conversely, if no response was observed, a lower dose one gradient down was chosen, with adjacent dose differences of 0.01 mg/kg. The ED50 and ED95 of ciprofol combined with nalbuphine for inhibiting laryngeal mask insertion responses were calculated along with their respective 95% confidence intervals (CIs). Results: The ED50 value of nalbuphine for inhibiting laryngeal mask insertion responses was found to be 0.149 mg/kg (95% CI: 0.142–0.155 mg/kg), while the ED95 value was determined to be 0.160 mg/kg (95% CI: 0.154–0.191 mg/kg).Conclusion: When combined with ciprofol, the ED50 of nalbuphine for inhibiting laryngeal mask insertion responses in patients undergoing outpatient hysteroscopic surgery is established at 0.149 mg/kg (95% CI: 0.142–0.155 mg/kg), and the ED95 is set at 0.160 mg/kg (95% CI: 0.154–0.191 mg/kg).
Research on the Immunomodulatory Effects of Krill Oil
Authors: Shaw David Bernard , Haim Lasser
Published: January 2025

Krill oil, as an emerging marine lipid, has garnered considerable attention due to its abundant bioactive components, including Omega-3 fatty acids, phospholipids, and astaxanthin. This article provides a comprehensive review of the immunomodulatory effects of krill oil and its underlying mechanisms, as explored through both animal experiments and clinical studies. It delves into the impact of krill oil on immune organs, immune cells, and immune function. The research findings demonstrate that krill oil can enhance the functionality of immune organs, modulate the activity of immune cells, and bolster the immune capacity of the body. These insights not only provide scientific support for the potential value of krill oil in dietary supplements, functional foods, and clinical applications but also open new avenues for research and application in the field of immunoregulation.
Application of Dunhuang Mural Elements in the Modeling and Action Design of the “Luo Shen’s Graceful Flight” Segment in the Animated Film Yang Jian
Authors: Han Dan , Dai Lingrui
Published: January 2025

Taking the 3D animation Yang Jian’s segment “Luo Shen’s Graceful Flight” as an example, this paper analyzes how Dunhuang mural elements inspire the modeling and action design in 3D animation. It explores the influence of Dunhuang murals on animation modeling and movement design, and offers an artistic analysis of the “Luo Shen’s Graceful Flight” in Yang Jian. This study discusses how to retain the core aesthetic of Dunhuang mural art within the scope of current technological methods, and how to convey the distinctive Eastern characteristics of Chinese traditional culture beyond the principles of Disney-style modeling and action design, providing a viable approach for Chinese animation creation.
Research Progress on the Mechanisms of Neutrophil Extracellular Traps in Diabetic Wound Healing
Authors: Wu Lin , Yu Zhiyong , Xiao Ketao , Zhao Lijin
Published: January 2025

Diabetes is a prevalent metabolic disease that poses a significant challenge to public health due to the development of difficult-to-heal skin ulcers in approximately one-quarter of patients. Neutrophil extracellular traps (NETs) are mesh-like structures released by neutrophils, initially believed to play a crucial role in combating microbial infections. However, an increasing body of research suggests that NETs also contribute to the pathogenesis of various diseases, including diabetic wounds. Studies have demonstrated that NETs can trigger excessive inflammatory responses, impede re-epithelialization and angiogenesis, and disrupt normal wound healing processes in individuals with diabetes. This article provides an overview of NETs, their mechanisms of action, and explores potential treatment strategies for diabetic wounds, aiming to offer novel insights for improving diabetic wound management.
Causal Role of Oxidative Stress-Related Genes in Osteoarthritis
Authors: Chen Junjie , Meng Qingqi
Published: January 2025

Background: Osteoarthritis (OA) is a common joint disease, primarily affecting the elderly. Oxidative stress (OS), resulting from an imbalance between oxidants and antioxidants, plays a significant role in OA progression. This study aimed to explore the causal relationship between OS-related genes and OA using summary-based Mendelian randomization (SMR).
Methods: OS-related genes were selected from the GeneCards database with a relevance score ≥ 7. GWAS data for OA, including 24,955 cases and 378,169 controls, were retrieved from the IEU database. eQTL data were obtained from the eQTLGen Consortium. SMR analysis was conducted to assess the causal effects of gene expression on OA, with the HEIDI test used to confirm the absence of heterogeneity. Colocalization and enrichment analyses were performed, and regulatory networks for key genes were predicted. Results: SMR analysis identified 26 OS-related genes with causal links to OA. Seven genes were associated with an increased risk of OA, while 19 were protective. Enrichment analysis revealed pathways such as "response to oxidative stress" and "cellular oxidant detoxification." Colocalization analysis indicated LYRM4 and MAPK3 likely share causal variants with OA, and regulatory network predictions highlighted genes like NFS1 and ELK1 as potential regulators of LYRM4 and MAPK3. Conclusion: This study identified several OS-related genes potentially contributing to OA, with LYRM4 and MAPK3 as key candidates. These findings offer insights into OA pathogenesis, suggesting that mitochondrial dysfunction and inflammatory signaling play crucial roles. Further research is needed to validate these results and explore potential therapeutic strategies targeting these genes.
Strategies for Constructing Osteosarcoma 3D Culture Models and Progress in Their Applications
Authors: Qin Changshuai , Huang Na , Qin Chengyi , Huang Cheng , Qiu Zonghui , Wang Jinheng , Fu Wei , Liu Wusong , Peng Wei , Lan Changgong
Published: January 2025

Osteosarcoma is a highly malignant primary bone tumor, and traditional two-dimensional (2D) culture methods cannot accurately simulate the tumor microenvironment. Three-dimensional (3D) culture better simulates the in vivo tumor microenvironment, providing more realistic experimental data regarding tumor progression, drug resistance, and drug screening. This paper introduces various 3D culture technologies, including scaffold-free culture, scaffold-based culture, microfluidic chips, and bioprinting. Moreover, 3D models show significant advantages in tumor microenvironment simulation, drug screening, and research on osteoblasts and osteoclasts, thus promoting the development of personalized therapy. Overall, 3D culture offers an important tool and platform for a deeper understanding of osteosarcoma's biological mechanisms and improving clinical treatment outcomes.
Applications of Visual Perception in Autonomous Driving
Authors: Xi Zhiyu
Published: January 2025

This paper focuses on the application of visual perception in autonomous driving.  The types of cameras in visual perception systems are introduced, including charge-coupled device (CCD), and Complementary metal oxide semiconductor (CMOS) image sensors, and the LiDAR system with vision sensors. The applications of visual perception in autonomous driving are discussed, such as environmental perception (including road recognition, lane line detection, and traffic sign and signal light recognition) and vehicle positioning. However, visual perception technology faces challenges, such as the effects of light changes and interference from harsh weather on visual sensors. To address these challenges, solutions include the fusion of vision and other sensors, as well as progress in hardware and software technology. By optimizing and improving visual sensors in terms of precision, cost, power consumption, stability, and data perception and processing ability, the performance of autonomous driving systems can be enhanced. The multi-sensor fusion method utilizes the advantages of different sensors to obtain more comprehensive environmental information and improve the reliability and adaptability of the vehicle system. This paper can help autonomous driving researchers understand the application of visual sensors in autonomous driving more quickly.
A Theoretical Exploration of Acupuncture for Non-Specific Low Back Pain Based on the Jingjin Theory
Authors: Chen Liping , Yang Li
Published: January 2025

Non-specific low back pain (NLBP) is a common soft tissue injury in clinical practice, characterized by varying degrees of pain and discomfort in the lower back. Its etiology often lacks clear specificity. Patients exhibit dysfunction of the sinew channels, often accompanied by muscle stiffness, restricted mobility, and impaired quality of life. According to traditional Chinese medicine (TCM) theory, NLBP is classified as "sinew impediment" (Jin Bi), with its pathogenesis attributed to sinew channel dysregulation and impaired circulation of qi and blood. Sinew channels are responsible for "binding the bones and facilitating the joints," playing a crucial role in maintaining skeletal stability, joint mobility, and overall movement coordination. The sinew channels in the lower back are closely related to the six-foot meridians, providing a significant theoretical foundation for diagnosis and treatment. Guided by sinew channel theory, palpation techniques are used to precisely locate lesion points, primarily focusing on "sinew knots" along the sinew channel pathways. Sinew knots are typically characterized by localized tissue tension, hard nodules, or tender points. During diagnosis, analyzing the distribution characteristics and depth of lesion points helps define the extent and severity of the condition, laying the groundwork for developing personalized treatment plans. Acupuncture is one of the primary TCM interventions. By needling lesion points to stimulate sinew channels, it can unblock meridians, regulate qi and blood, and alleviate the "sinew impediment" condition. Precision is central to acupuncture practice, with careful adjustments to needle depth and angle to target the affected tissues effectively, thereby relieving pain and restoring function. The application of sinew channel theory not only provides a reliable basis for the diagnosis and treatment of NLBP but also offers new perspectives for addressing other sinew-related conditions. Clinical practice of precision acupuncture further validates the effectiveness of this theory, offering scientific support for advancing traditional TCM techniques and integrating them with modern medical approaches.
The Current Status and Optimization Strategies of Scientific Research Management in Applied Universities
Authors: Xu Peiquan
Published: January 2025

This article analyzes the deficiencies in the scientific research management of applied universities and proposes strategies for improvement. These shortcomings include the loss of scientific research talent, lack of clear research directions, insufficient construction of research platforms, and low quality of industry-university-research cooperation. The article suggests optimizing research management by establishing talent introduction mechanisms, strengthening practical teaching, clarifying research objectives, enhancing research cooperation and technology transfer, improving research platform construction, and strengthening industry-university-research collaboration. The aim is to enhance the level of scientific research, promote technological innovation and industrial upgrading, and support national and local economic development.
On the Significance of the Application of Environmentally Friendly Fabrics to the Sustainable Development of the Clothing Industry
Authors: Zhang Jinghao
Published: January 2025

In recent years, environmental protection has received great attention from all walks of life, and economic development is no longer pursued at the expense of the environment. Against this backdrop, various industries have actively responded to the call of China's environmental protection policies and carried out their work adhering to the modern concept of environmental protection, and so has the clothing industry. As a carrier of culture and fashion, the sustainable development issue of the clothing industry has become increasingly prominent. To meet consumers' pursuit of a healthy and environmentally friendly lifestyle, the clothing industry should clarify the value of environmentally friendly materials, minimize the use of chemical raw materials in the production process, and reduce environmental pollution. Based on this, the innovative application of new environmentally friendly materials in modern clothing can reduce its environmental pollution and enhance the environmental friendliness of modern clothing design, thereby promoting the sustainable development of the clothing design industry. This article aims to provide useful references and inspirations for the sustainable development of the clothing industry by systematically analyzing the types, characteristics of environmentally friendly fabrics and their application status in the clothing industry.
IL RUOLO DELL’APPRENDIMENTO INFORMALE DELLA LINGUA ITALIANA NELLO STIMOLARE LA RIFLESSIONE METACOGNITIVA DEGLI STUDENTI DI FILOLOGIA. UN ESEMPIO DI FILM E SERIE TV IN ITALIANO
Authors: Grabowska Monika , Zapłotna Agata
Published: January 2025

Obiettivo dell’articolo è quello di identificare in che misura gli studenti polacchi di filologia italiana beneficiano delle possibilità offerte dai moderni strumenti digitali per l’apprendimento informale dell’italiano attraverso film e serie in lingua italiana e in che modo questa attività stimola la loro consapevolezza metacognitiva e la loro autoconsapevolezza nell’ambito dell’apprendimento delle lingue straniere. I risultati dell’indagine presentati nell’articolo dimostrano che i film e le serie TV sono un modo importante di passare il tempo per gli studenti della generazione Z e che i materiali audiovisivi non solo forniscono un materiale didattico prezioso, ma supportano anche l’assunzione di responsabilità per il proprio apprendimento.
 
The role of informal learning of Italian as a foreign language in stimulating the metacognitive reflection of Italian philology students. Example of Italian-language films and series
The aim of the article is to identify the extent to which Polish students of Italian philology benefit from the possibilities offered by modern digital tools for informal learning through Italian-language films and series and how this activity stimulates their metacognitive awareness and self-awareness in the field of foreign language learning. The survey results presented in the article show that films and TV series are an important way of spending time for “Generation Z” students and that audiovisual materials not only provide valuable learning affordances but also support taking responsibility for their own learning.
The environmental sublime: an analysis beyond nature and culture
Authors: Feloj Serena
Published: January 2025

This article explores an actualisation of the Kantian sublime with reference to environmental aesthetics, examining its relevance and transformation in light of the current debate around the 'environmental humanities'. The main thesis of this article is that it is possible to actualise the Kantian sublime in the context of environmental aesthetics, emphasising the counterpurposiveness element of nature. This aspect makes it possible to show a dialectical relationship with nature, overcoming the mere opposition between nature and culture and promoting ethical responsibility. In other words, the sublime can help us recognise the relevance of direct experience of nature and the need for a more respectful and sustainable relationship.
Il co-sentire e l'esperienza del mondo magico. Appunti per una ricezione del Sympathiebuch di Max Scheler ne Il mondo magico di Ernesto De Martino
Authors: Gristina Silvestre
Published: January 2025

The contribution aims to investigate the influence of Max Scheler’s Wesen und Formen der Sympathie on Ernesto De Martino’s thought, during the elaboration period of Il mondo magico’s theoretical framework. The paper claims that De Martino’s approach to Scheler’s phenomenology can be included among the conditions of possibility of the Italian philosopher’s detachment from idealism and of the formulation of his original epistemological stance. Within this framework, tracing Sympathiebuch’s line of influence on De Martino would make possible to read the problem of the experience of magic from a phenomenological standpoint. In the first section, the paper provides an outline of the philosophical and cultural environment in which De Martino came into contact with phenomenology and, specifically, with Scheler’s philosophy. In the second section, the paper presents the features of Scheler’s philosophy that would influence De Martino’s thougt in the first half of the 1940s. To this purpose, the contribution takes into account Sympathiebuch’s main conceptual cores, taking as its guiding thread the definition of the phenomenological concept of Mit-fühlen and the possibility to extend its potentialities to an ethnological project. In the third section, the paper presents an interpretation of Il mondo magico in the light of Scheler’s categories, highlighting the argumentative junctures in which the phenomenological conceptual toolkit seems to be most effectively employed by De Martino in the study of magic and ritual phenomenona.
Influenza Vaccination Coverage in Patients with Chronic Diseases: A Descriptive Analysis
Authors: Contarino Fabio Massimo , Bella Francesca , Randazzo Concetta , Fiorilla Claudio , Contrino Maria Lia
Published: January 2025

Background: Influenza is a major cause of morbidity and mortality worldwide. Individuals with chronic diseases are at greater risk of severe disease or complications. Annual influenza vaccination is fundamental to reduce the burden of disease. Patients with chronic diseases often remain hard to reach and vaccination coverage data are poorly available. The aim of this study is to evaluate the influenza vaccination coverage in subjects from 6 months to 64 years of age with chronic diseases during the 2023/2024 season in Siracusa Local Health Authority, Italy.Methods: Records of influenza vaccination during 2023/2024 vaccination campaign were matched with the information on chronic diseases. The dataset included information on sex, age, influenza vaccine, chronic diseases, other vaccines administered. Results: During 2023/24 influenza season, vaccination coverage among the study population was 16.3% and it significantly differed, depending on the underlying disease. The higher VCs were reached in patients with chronic lung diseases (2627/5596; 46.9%), cardiovascular diseases (3250/7009; 46.4%) and chronic liver diseases (105/250; 42.0%), while the lower values were reached in patients with cancers (652/5630; 11.6%) and in patients with chronic inflammatory diseases and bowel malabsorption syndromes (159/1260; 12.6%).Conclusions: Although influenza vaccination is a safe, effective, and cost-effective method of preventing influenza infection and its complications, VC rates are not satisfactory, and coverage target indicated by Health Authorities remained very far. Reversing this is likely to require a broad range of interventions on patients, caregivers, parents, healthcare providers and health communication.
Donne, mafie ed esperienza teatrale in carcere. Lo spazio scenico come opportunità di trasformazione
Authors: Piovesan Ilaria
Published: January 2025

L’articolo analizza l’esperienza delle detenute del carcere di Vigevano coinvolte nel laboratorio teatrale promosso nell’ambito del progetto “Educarsi alla legalità”. Esplorando le pratiche autoriflessive e i percorsi di consapevolezza biografica di quattro detenute-attrici, l’articolo indaga le modalità attraverso cui l’attività teatrale ha contribuito alla trasformazione delle loro pratiche quotidiane, così come dei modelli di autorappresentazione.
Giuseppa Di Sano: una donna alle origini dell'antimafia civile
Authors: Santino Umberto
Published: January 2025

Il contributo introduce il documento relativo alla deposizione di Giuseppa Di Sano, allegato a una relazione del questore di Palermo Ermanno Sangiorgi del 20 novembre 1898 –.  Spinta non solo dal legame materno, ma soprattutto dalla necessità di proteggere la propria attività e la propria dignità la donna trovò il coraggio di denunciare la mafia per l’uccisione della figlia Emanuela.
Un ricordo di Fulvio Papi
Authors: Maranesi Alessandro
Published: January 2025

The article commemorates Fulvio Papi, reflecting on his legacy in Theoretical and Aesthetic Philosophy during a special volume presentation at Collegio Ghislieri, Pavia. It highlights Papi's unique ability to blend theoretical rigor with acute awareness of contemporary realities, making philosophy relevant to social issues. Papi is praised not only as a teacher to his students but also as an inspiring figure for those less immersed in philosophical studies. The article emphasizes Papi's approachable and ironically humorous demeanor, which profoundly impacted students, exemplifying his educational philosophy that extended beyond traditional academic boundaries. It underscores his role in promoting interdisciplinary teaching, leaving a lasting influence on academic and public discourse.
Giornata del rispetto di ogni Spiritualità
Authors: Biavaschi Gigliola , Mignani Giulio
Published: January 2025

The Giornata del Rispetto di ogni Spiritualità (Day of Respect for All Spiritualities) advocates for a cultural shift towards inclusivity and dialogue amidst increasing societal tensions. Founded in Liguria, the event emphasizes the recognition of spirituality as a universal dimension of human experience, transcending religious and secular divides. Participants are encouraged to reflect on shared values, reject absolutist claims to truth, and honor the diverse ways individuals connect with the transcendent. By fostering silent meditation and collective acknowledgment of mutual spiritual depth, the initiative seeks to transcend traditional ecumenism, addressing both interfaith and intra-faith challenges while promoting a culture of respect and harmony.
In ricordo di Renato Rozzi
Authors: Matteriali di estetica  , Scaramuzza Gabriele
Published: January 2025

Necrologio sulla morte di Renato Rozzi a cui la rivista intende dedicare le prossime uscite.
ROLE OF VITAMIN C AS AN ADJUVANT THERAPY IN PATIENTS WITH SEVERE PNEUMONIA IN TERMS OF REDUCED HOSPITAL STAY
Authors: ZAHID T , HAIDER N , SAADAT R , ZAHRA FT , REHMAN H , FAROOQ A
Published: January 2025

Vitamin C is well-known for its antioxidant and immune-boosting properties, which can theoretically influence respiratory infections. Numerous studies have explored the role of vitamin C in preventing and treating respiratory infections such as pneumonia in adults. However, there is limited on its effects as adjuvant treatment in pneumonia, in the pediatric population. We conducted this study to compare the effects of vitamin C vs placebo along with standard therapy, reducing the mean hospital stay duration in children with severe pneumonia. Methods: We conducted a randomized control trial over 1 year (1st September 2023 to 30th August 2024) in Children's Hospital, PIMs. We recruited 120 children aged 2 months to 60 months admitted with severe pneumonia. The patients were divided into two groups GROUP A and GROUP B by randomization using the lottery method. Group A received standard antibiotics plus 200 mg of vitamin C daily and Group B received standard antibiotics with a placebo. Duration of hospital stay, duration of fever, cough duration, days on oxygen, days to improve respiratory distress, and days to improve tachypnea were taken as outcomes Results: This study aimed to assess the clinical efficacy of Vitamin C supplementation in patients' children with severe pneumonia, focusing on its impact on hospital stay duration. Additional outcomes evaluated included the duration of fever, cough, oxygen use, respiratory distress, and tachypnea. The findings from our randomized controlled trial (RCT) revealed no statistically significant differences between the Vitamin C and placebo groups for any of these outcomes. This included hospital stay duration (p = 0.57), fever duration (p = 0.49), cough duration (p = 0.51), days on oxygen (p=0.73), days with respiratory distress (p=0.32), and duration of tachypnea (p-values= 0.93). Conclusion: Although the role of Vitamin C in immune support, its antioxidant activity and anti-inflammatory activity theoretically justify its use in pneumonia, the findings of our study conducted on children did not indicate any significant impact of Vitamin C use on the clinical progression of the disease.