bluuebunny/crossref_metadata_2025 huggingface dataset:
SARS-CoV-2: the key issues
Authors: Raczkowska-Łabuda Karolina , Zawadzka-Głos Lidia
Published: April 2021

At the end of 2019, in the industrial city of Wuhan, which is the capital of the Chinese province of Hubei, a new coronavirus disease (nCoV-19) began to erupt. At the beginning, the scale of the threat posed by the virus was underestimated, and the information coming from China was residual and does not provide a complete picture of the situation. Since then, nCoV-19 has spread to 183 different countries around the world, causing many cases and thousands of deaths. On March 11, World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus officially declared the COVID-19 outbreak a pandemic. This review work aims to provide some basic information about the virus (SARS-CoV-2) and the disease it causes (COVID-19). In addition, it covers diagnostic methods, recommended management and methods to reduce the extent of infection. This is a kind of summary of the state of knowledge at the end of April 2020. To summarize main observations based on the review of world literature on the subject is driving us into conclusion that the transmission mechanisms of SARS-CoV-2 are not fully recognized. The spread of the virus from human to human occurs mainly through respiratory drops; symptomatic infections spectrum ranges from mild to critical, with a significant prevalence of mild/asymptomatic cases. Molecular test for the SARS-CoV-2 virus RNA is currently recommend. Other test include rapid direct SARS-CoV-2 antigen or indirect antibody detection, lung CT and LUS. Recommendation for ENT surgical procedures are collected in The International Paediatric Otolaryngology Group (IPOG) statement published on the 14th of April 2020.Personnel involved in aerosol generating procedures should be fitted with PPE.
Aspekty diagnostyczne i terapeutyczne zespołu Marfana w wieku rozwojowym
Authors: Ludzia Małgorzata , Smereczyńska-Wierzbicka Ewa , Werner Bożena
Published: April 2021

Marfan’s syndrome (MFS) is a systemic, autosomal dominant connective tissue disease. It is caused mainly by the mutations in the FBN1 gene and is connected with extracellular matrix protein fibrillin-1. The incidence is about 2-3 per 10 000. About 70-75% of cases are inherited in an autosomal dominant fashion and the remaining are de-novo mutations. The most common findings involve cardiovascular, ocular and skeletal systems. The cardinal manifestations typically involving MFS are aortic root aneurysm/dissection and ectopia lentis. The other common manifestations are mitral valve prolapse, proximal aortic aneurysm, dolichocephaly, pectus carinatum deformity, enophthalmos, scoliosis, long-bone overgrowth. The manifestation in neonatal Marfan syndrome, in contrast to classical Marfan syndrome, is a rapidly progressing multi-valvular cardiac disease. The death connected with congestive heart failure happens mainly within the first year of life. Prognostic factors for life expectancy of patients with Marfan syndrome depend on the type of the MFS and in classical MFS – depend on the rate of aortic root dilatation, which leads to dissection or rupture. Pharmacological management includes beta blockers, angiotensin receptor blockers and angiotensin converting enzyme inhibitor as a preventive treatment to slow aortic root dilation.
Zastosowanie eltrombopagu w leczeniu przewlekłej małopłytkowości immunologicznej u dziecka – doświadczenia własne
Authors: Adamowicz-Salach Anna , Matysiak Michał
Published: April 2021

Immune thrombocytopenia purpura (ITP) is a rare autoimmune disorder but it is one of the most common bleeding disorder in childhood. Most children with this disease have acute form of ITP with self-limiting thrombocytopenia. A small subset of children with ITP has clinically significant disease with severe thrombocytopenia. We presented the case of a boy with a severe form of chronic immune thrombocytopenia who was treated for the first time six years before presented. At first autoimmunohemolytic anaemia was recognized. Next in therapeutic procedure, multi-drug treatment, including intravenous corticosteroids, intravenous immunoglobulins, and cyclosporine were used to achieve permanent improvement. Due to a chronic ITP and significant decrease platelets counts and severe symptoms of nose bleeding and anaemia, eltrombopag, thrombopoiesis stimulating factor, was used. After 16 weeks of treatment, as a result of triple therapy consisting of eltrombopag, prednisone and azathioprine, the platelets counts were normalized and the symptoms of bleeding resolved.
Otyłość w chorobach przewlekłych u dzieci
Authors: Koch Katarzyna , Łaguna Paweł , Mikłasz Justyna , Matysiak Michał
Published: April 2021

Obesity develops as a result of long-term positive energy balance, with the participation of genetic, environmental factors and comorbidities. Obesity and overweight is currently one of the major health problems in many countries around the world, including Poland. The problem of excessive body mass is also increasingly affecting children and adolescents, and the number of overweight or obese people is rising fast in this group. Currently, every fifth child in Poland is obese or overweight. As overweight, we define excessive accumulation of adipose tissue, that does not meet the criteria for diagnosing obesity (BMI 85-95th percentile). Obesity is defined as excessive accumulation of adipose tissue leading to eterioration of health (> 95th percentile). Overweight and obesity coexist with many chronic diseases and complicates the course of comorbidities. Excessive body weight is an important risk factor of premature death. Obesity prevention and treatment can improve the course of co-morbid diseases and should be the basis of patient care.
The Weimar Republic and the War of Memory
Authors: Dixon Madeline
Published: April 2021

World War I dismantled Imperial Germany and, long after the fighting had ceased, continued to shape the newly-born Weimar Republic. This paper argues that a war over the memory of the Great War in Germany led to Weimar’s downfall. The Weimar Republic’s lack of a collective memory of the first total war became the center of the political debate on the republic’s viability and Germany’s future. This war debate was potently wielded in the arenas of literature and art to heighten political conflict and ensure that the war’s memory seeped into every aspect of society. Ultimately, Weimar’s inability to promote any consensus on the war’s meaning in the face of opposition from the conservative and extremist right weakened the republic significantly and led to its downfall.
Treatment of pyogenic granuloma with copper vapor laser radiation
Authors: Ponomarev Igor V. , Shakina Ludmila D. , Topchiy Sergey B. , Klyuchareva Svetlana V. , Pushkareva Alexandra E.
Published: April 2021

Background. Pyogenic granuloma (PG) or lobular capillary hemangioma, ICD10 code: L98.0. appears as a single bright red or violet papule up to 20 mm in size, on the face, fingers, skull surface, arms, and intergluteal fold, as well as on the oral mucous membranes. Surgical removal of facial PG is not always possible due to insufficient thickness of the dermis. Treatment of PG with a pulsed dye laser (PDL) or neodymium laser (Nd:YAG) can achieve a noticeable elimination of the lesion but is reported to be accompanied by such side effects as purpura or scarring. It determines the feasibility of introducing into clinical practice the methods of laser treatment of PG using the radiation of a copper vapor laser (CVL) with a wavelength of 578 nm, which effectively absorbed by the blood.
Aim. The assessment of the clinical efficacy and safety of the CVL treating PG.
Methods. 26 adult patients with PG in various parts of the face, including the lips, limbs, and trunk, were included in this study. PG treatment was carried out in one session with CVL (Yakhroma-Med, FIAN) at an average power of 0.71.0 W, at a wavelength of 578 nm, exposure time 0.20.3 s. The diameter of the light spot is 1 mm.
Results. Immediately after the single laser treatment, the PG involved area became grey. In 710 days, the irradiated area was utterly similar to the adjacent intact skin. No postoperative bleeding or infection was noted. Side effects included mild skin atrophy. During the follow-up observation for five years, no side effects were found.
Conclusion. The high efficiency of PG elimination using CVL in the absence of pronounced side effects allows suggesting this method for introducing into dermatologists and cosmetologists' clinical practice as a highly effective and inexpensive method of treatment.
ESTRATÉGIA DE INTERAÇÕES EFETIVAS TRANSABERES: UMA ANÁLISE COM BASE NA CIÊNCIA PÓS-NORMAL E NO PRINCÍPIO PLURALISTA
Authors: Ribeiro Claudio de Oliveira , De Mello Bobiquins Estevão
Published: April 2021

A pesquisa que ora relatamos baseou-se em teorias de diversas áreas do conhecimento humano — Arte, Ciência, Filosofia e Religião — que tivessem em comum a busca por mudanças estruturais na sociedade contemporânea, compatíveis com a complexidade dos problemas atuais. Nosso objetivo foi propor uma estratégia dialógica de interações entre os agentes do saber, focada na solução de problemas. Usamos a teoria da Transdisciplinaridade, de base filosófica, a Ciência Pós-Normal, científica, e o Princípio Pluralista, de origem teológica, para compor a Estratégia de Interações efetivas Transaberes. O presente artigo também introduz o conceito de Transaberes, como movimento dialógico entre os Saberes, Fazeres e Poderes da sociedade.
Atlas of fundus fluorescence angiography in retinopathy of premature infants
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution Kaluga Branch, Tereshchenko A.V. , Trifanenkova I.G. ,   The S. Fyodorov Eye Microsurgery Federal State Institution Kaluga Branch
Published: April 2021

В атласе представлены результаты собственных многолетних исследований авторов по разработке и внедрению инновационных методов диагностического мониторинга ретинопатии недоношенных с использованием флюоресцентной ангиографии. Систематизированный иллюстративный материал демонстрирует многообразие флюоресцентно-ангиографических феноменов, тщательная интерпретация которых позволяет расширить представления о патологических изменениях сосудистой системы сетчатки и хориоидеи у пациентов в активном периоде ретинопатии недоношенных. Результаты послеоперационного динамического мониторинга пациентов, перенесших лазерное и хирургическое лечение, а также их комбинацию, демонстрируют широкие возможности флюоресцентной ангиографии как в ранней оценке регресса ретинопатии недоношенных, так и в обнаружении доклинических признаков прогрессирования патологического процесса для своевременного проведения лечебных мероприятий. Авторами также показаны данные международного клинического исследования «Rainbow», свидетельствующие о перспективности анти-VEGF-терапии в раннем лечении тяжелых стадий активной РН. Книга предназначена для практикующих врачей-офтальмологов.
PRIORITY DIRECTIONS OF OPTIMIZATION OF OPERATIONAL ACTIVITY MANAGEMENT OF PRIVATE MEDICAL INSTITUTIONS
Authors:   Kyiv National Economic University named after Vadim Hetman, Osokina Alla , Syvytska Kateryna ,   Kyiv National Economic University named after Vadim Hetman, Fatalchuk Tetiana ,   Kyiv National Economic University named after Vadim Hetman
Published: April 2021

The specifics of medical services have been updated, which determines the features of operational management of private medical institutions. It is argued that the most rational direction of improving the management of operational activities of private medical institutions should be based on the concept of «value disciplines» F. Wirsem and M. Tracy: ensuring operational excellence, innovative leadership, customer-centricity. On the basis of economic substantiation of projects of improvement of management of operational activity of «Clinic of anti-aging «MEDIKOM» the theoretical conclusions are empirically confirmed and their applied significance is proved.
Ehrlichia Meningoencephalitis: A Case Series
Authors:   Department of Neurology, The Ohio State University, USA, J Morena , M Antimisiaris ,   Department of Neurology, The Ohio State University, USA, D Singh ,   Department of Neurology, The Ohio State University, USA
Published: April 2021

Objective: We present the distinct clinical and laboratory findings in two cases of Ehrlichia meningoencephalitis, along with one suspected case. Background: The number of cases of Ehrlichia chaffeensis reported to the CDC has more than doubled from 2007-2017. A PubMed literature search using the words “Ehrlichiosis and meningoencephalitis” revealed five case reports with neurologic manifestations. Design/Methods: This is a retrospective observational study. Two elderly patients presented with encephalopathy, fever, transaminitis, thrombocytopenia, a positive E. chaffeensis Polymerase Chain Reaction (PCR) in Serum, and Cerebrospinal Fluid (CSF) with a lymphocytic or neutrophilic pleocytosis and elevated protein. One patient had similar symptoms and a positive E. chaffeensis PCR, but lumbar puncture was unable to be performed due to severe thrombocytopenia. They presented in May or June. Doxycycline was started within 2-3 days after presentation to the hospital. Follow up five months later revealed all patients were close, or back to baseline. Results and Conclusions: Suspicion of Ehrlichia meningoencephalitis should be raised in elderly patients presenting with fever and encephalopathy in the summer season with history of tick bite or residence in wooded areas. Thrombocytopenia and transaminitis should raise further suspicion. CSF studies typically show a lymphocytic pleocytosis and elevated protein. PCR technique allows for direct detection of pathogen-specific DNA and is the preferred method of detection during the acute phase of illness. Prompt treatment with doxycycline results in good outcomes. Doxycycline is not included in the typical meningitis regimen, therefore, this disease is important to quickly identify as delay in Doxycycline can result in worse outcomes.
Sustainable Diets, A Way to Improve and Maintain Eating Behaviors and Health in Times of COVID-19 in First-Year University Students
Authors:   Master´s Program in Sustainable Tropical Agiculture, Graduate Department, Zamorano University, Honduras, JP Enriquez , SW Bodden ,   Consultant at Equilibrium, Honduras, AS Hernandez ,   Human Nutrition Laboratory, Department of Food Science and Technology, Zamorano University, Honduras
Published: April 2021

Sustainable dietary pattern has reported multiple benefits for environmental and human health through sustainable food culture. The Covid-19 pandemic has led the population to adapt to a new virtual reality in all activities and to become more aware of their health. This study explores how evaluate the impact of nutritional education interventions on adherence to MD in first-year university adolescents, before and after the nutritional educational intervention. A total of 165 students participated in the experiment (85 intervention group and 80 control group). A 14-point questionnaire was applied for the adherence to the MD. The study consists of four presential sessions and four virtual sessions using social media to complete the training. The t-tests show that the group with interventions did not change its adherence during the two periods of data collection (p=0.187), contrary to the control group which significantly decreased (p=0.001) from 7.41 to 6.62. It has been concluded that it is necessary to work on institutional policies that promote the benefits of this dietary pattern as a lifestyle that would be beneficial to better cope with the pandemic, since many of the products of the MD are used in Latin-American countries for several years.
Investigation into the Re-Arrangement of Copper Foams Pre- and Post-CO2 Electrocatalysis
Authors: Rudd Jennifer , Herrnandez-Aldave Sandra , Kazimierska Ewa , Hamdy Louise B. , Bain Odin , Barron Andrew R. , Andreoli Enrico
Published: April 2021

The utilization of carbon dioxide is a major incentive for the growing field of carbon capture. Carbon dioxide could be an abundant building block to generate higher value products. Herein, we fabricated a porous copper electrode capable of catalyzing the reduction of carbon dioxide into higher value products such as ethylene, ethanol, and propanol. We investigated the formation of the foams under different conditions, not only analyzing their morphological and crystal structure but also documenting their performance as a catalyst. In particular, we studied the response of the foams to CO2 electrolysis, including the effect of urea as a potential additive to enhance CO2 catalysis. Before electrolysis, the pristine and urea-modified foam copper electrodes consisted of a mixture of cuboctahedra and dendrites. After 35-minute electrolysis, the cuboctahedra and dendrites underwent structural rearrangement affecting catalysis performance. We found that alterations in the morphology, crystallinity, and surface composition of the catalyst were conducive to the deactivation of the copper foams.
Phosphorene–Fullerene Nanostructures: A First-Principles Study
Authors: Cortes-Arriagada Diego , Ortega Daniela E.
Published: April 2021

Hybrid materials formed by carbon fullerenes and layered materials have emerged due to their advantages for several technological applications, and phosphorene arises as a promising two-dimensional semiconductor for C60 adsorption. However, the properties of phosphorenefullerene hybrids remain mainly unexplored. In this work, we employed density functional theory to obtain structures, adsorption energies, electronic/optical properties, binding (AIM, NBO), and energy decomposition analyses (ALMO-EDA) of nanostructures formed by phosphorene and fullerenes (C24 to C70). We find fullerenes form covalent and non-covalent complexes with phosphorene depending on the molecular size, showing remarkable stability even in solution. Two classes of covalent complexes arise by cycloaddition-like reactions: the first class, where short-range effects (charge-transfer and polarization) determines the stability; and the second one, where short-range effects decay to avoid steric repulsion, and balanced longrange forces (electrostatics and dispersion) favors the stability. Otherwise, high-size fullerenes (C50 to C70) only form non-covalent complexes due to strong repulsion at shorter intermolecular distances and lack of dissociation barriers. In terms of electronic properties, fullerenes act as mild p-dopants for phosphorene, increasing its polar character and ability to acquire induced dipole moments (polarizability). Also, small energy-bandgap fullerenes (<0.8 eV) largely increase the phosphorene metallic character. We also note fullerenes retain their donor/acceptor properties upon adsorption, acting as active sites for orbital-controlled interactions and maximizing the phosphorene light absorbance at the UV-Vis region. Finally, we strongly believe our study will inspire future experimental/theoretical studies focused on phosphorene-fullerene uses for storage, anode materials, sensing, phosphorene bandgap engineering, and optoelectronics.
Quantum Surface Control of Trapped Bose-Einstein-Condensates
Authors: Wang Quan-Fang
Published: April 2021

In this work, quantum control of trapped Bose-Einstein-Condensates (BEC) is considered at matter surface. For particles at BEC status, quantum system is described by Gross-Pitaevskii equation, experimental control of BEC is happened at physics field, and achieved at laboratory. At theoretic aspect, control of trapped condensates is not sufficiently investigated at academic level. What we interest is applying control theory to BEC trapped on the surface (metallic, crystal). At optical lattice, particles are trapping by constrained forces at cooling technique, and temporally take the same quantum states, such kind of condensates phenomena had already been surveyed at a variety of areas. The most works are reported on free BEC particles, quite natural question is arising on the surface science: BEC particles created,detected, and placed on a certain chemical surface, control of trapped particles is difference or not? We are curious about optical and mechanical constraints take action together on particles. In the viewpoint of quantum control realm, our purpose is to apply optimal control theory (OCT) to trapped Bose-Einstein-Condensates as they are occurred at surface. In the framework of variational theory at complex Hilbert spaces, prove the existence of quantum optimal control, and characterize optimal control using optimality (Euler-Lagrange) system. Control variables for trapped BEC contain three functions: one is electro-magnetic force; another is external constraint from optical equipment (optical frequency, lattice number); third is quantum mechanics against gravitational force, which making BEC particles stay at surface stationary. Review the literatures, electro-magnetic-optical controls are extremely considered at last couple of years. Gravitational control is rarely considered. Further extension of the work is to do real-time computer-aided BEC control at matter surface. Computational approach for simulation of BEC control at two and three dimensions would be a promise direction.
Diels-Alder Additions to 2,2’-Biaceanthrylene
Authors: Du Yachu , Plunkett Kyle
Published: April 2021

A series of Diels-Alder reactions between the diene 2,2’-biaceanthylene and several dienophiles is presented. The diene is a cyclopenta-fused polycyclic aromatic hydrocarbon with anthracene units linked by two cyclopentene rings. Depending on the dienophile, the major product was the result of a single addition (dimethyl acetylenedicarboxylate) or double addition (quinone, benzyne) to the diene. Single crystal X-ray analysis of the quinone-derivative shows a propeller-like structure composed of mixed enantiomers. The synthesis and photophysical properties of these compounds is presented.
Synergistic Effect of a Mixed Culture in Solid-state Fermentation
Authors: Ong Adwin , Chi Lik Lee Ken
Published: April 2021

This study determines the efficacy of a mixed culture in solid-state fermentation from the perspective of cooperative metabolism, in which comparisons with pure culture fermentations were made. Assays performed include Total Phenolic Content (TPC), Total Dietary Fibre (TDF), and Crude Protein Content via the Kjeldahl Method.
Uncovering the Release of Micro/nanoplastics from Disposable Face Masks at Times of COVID-19
Authors: Morgana Silvia , Casentini Barbara , Amalfitano Stefano
Published: April 2021

This study aims to assess the environmental impact of discarded face masks, that are a source of emerging concern as indicated by most recent literature, although still little investigated. Herein we evaluated micro- and nanoplastic particles that can be released from face mask once subject to environmental conditions. Exposure to simulated-low shear forces demonstrated to be effective in breaking and fragmenting face mask tissue into smaller debris. Even at low shear energy densities, a single mask could release in water thousands of microplastic fibers and up to 10^11 submicrometric particles. The latter were quantified using flow cytometry that was proven to be a promising technique for nanoplastic counting, thus improving our understanding on distribution and fate of NPs still representing a great analytical challenge in plastic pollution research.
Enhanced Charge Transport in 2D materials through Polaritonic States
Authors: Bhatt Pooja , Kaur kuljeet , George Jino
Published: April 2021

Here, we observed enhancement of charge transport in 2D materials by light-matter strong coupling. Charge transport mobility is enhanced by 50 times under ON resonance condition. A clear correlation in the effective mass of the polaritonic state and Schottky barrier height may be indicating a coherent nature of light-matter interaction.
Catalytic Intramolecular Aminoarylation of Unactivated Alkenes with Aryl Sulfonamides
Authors: Noten Efrey , McAtee Rory , Stephenson Corey
Published: April 2021

Arylethylamines are abundant motifs in myriad natural products and pharmaceuticals, so efficient methods to synthesize them are valuable in drug discovery. In this work, we disclose an intramolecular alkene aminoarylation cascade that exploits the electrophilicity of a nitrogen-centered radical to form a C–N bond, then repurposes the nitrogen atom’s sulfonyl activating group as a traceless linker to form a subsequent C–C bond. This photoredox catalysis protocol enables the preparation of densely substituted arylethylamines from commercially abundant aryl sulfonamides under mild conditions. Reaction optimization, scope, mechanism, and synthetic applications are discussed.
Biovalorisation of Brewer's Spent Grain (BSG) and Sensory Evaluation of BSG Bread
Authors: Goh Luo Lin , Chi Lik Lee Ken
Published: April 2021

Brewer’ spent grain (BSG) is the largest by-product of beer production, generating over an approximate 38 billion kg annually. While the majority of BSG gets repurposed as animal feed, its usage unfortunately remains very limited. Due to the impressive nutritional profile of BSG, many studies have investigated its incorporation in food products. However, its substitution at high levels tend to bring about undesirable sensory changes. This paper looks at solid-state fermentation as a tool to enhance the nutritional profile of BSG. The consumer acceptance of fermented BSG- fortified bread was investigated, to understand the market value for fermented BSG food products compared to its unfermented counterpart. Of the 8 koji starters studied, M-1 (Aspergillus oryzae) brought about the greatest nutritional profile enhancement in terms of total phenolic content and crude protein content, with an optimal fermentation time of 4 days. No change in total dietary fibre content was observed after fermentation. From the sensory evaluation, fermented BSG-fortified bread had the best nutritional profile while having the poorest consumer acceptance. Despite the fact, this study highlights that fermentation may yet be an important tool in bridging the gap of BSG incorporation in food.
A Fragment Diabatization Linear Vibronic Coupling Model for Quantum Dynamics of Multichromophoric Systems: Population of the Charge Transfer State in the Photoexcited Guanine Cytosine Pair
Authors: Green James , Yaghoubi Jouybari Martha , Asha Haritha , Santoro Fabrizio , Improta Roberto
Published: April 2021

We introduce a method (FrD-LVC) based on a fragment diabatization (FrD) for the parametrization of a Linear Vibronic Coupling (LVC) model suitable for studying the photophysics of multichromophore systems. In combination with effective quantum dynamics (QD) propagations with multilayer multiconfigurational time-dependent Hartree (ML-MCTDH), the FrD-LVC approach gives access to the study of the competition between intra-chromophore decays, like those at conical intersections, and inter-chromophore processes, like exciton localization/delocalization and the involvement of charge transfer (CT) states. We used FrD-LVC parametrized with TD-DFT calculations, adopting either CAM-B3LYP or ωB97X-D functionals, to study the ultrafast photoexcited QD of a Guanine-Cytosine (GC) hydrogen bonded pair, within a Watson-Crick arrangement, considering up to 12 coupled diabatic electronic states and the effect of all the 99 vibrational coordinates. The bright excited states localized on C and, especially, on G are predicted to be strongly coupled to the G->C CT state which is efficiently and quickly populated after an excitation to any of the four lowest energy bright local excited states. Our QD simulations show that more than 80% of the excited population on G and ~50% of that on C decays to this CT state in less than 50 fs. We investigate the role of vibronic effects in the population of the CT state and show it depends mainly on its large reorganization energy so that it can occur even when it is significantly less stable than the bright states in the Franck-Condon region. At the same time, we document that the formation of the GC pair almost suppresses the involvement of dark nπ* excited states in the photoactivated dynamics.
Perchlorinated Triarylmethyl Radical 99% Enriched 13C at the Central Carbon as EPR Spin Probe Highly Sensitive to Molecular Tumbling
Authors: Poncelet Martin , Huffman Justin L. , Eaton Gareth R. , Moore Whylder , Eaton Sandra , Driesschaert Benoit
Published: April 2021

Soluble stable radicals are used as spin probes and spin labels for in vitro and in vivo Electron Paramagnetic Resonance (EPR) spectroscopy and imaging applications. We report the synthesis and characterization of a perchlorinated triarylmethyl radical enriched 99% at the central carbon, 13C1-PTMTC. The anisotropy of the hyperfine splitting with the 13C1 (Ax=26, Ay=25, Az=199.5 MHz) and the g (gx=2.0015, gy=2.0015, gz=2.0040) are responsible for a strong effect of the radical tumbling rate on the EPR spectrum. The rotational correlation time can be determine by spectral simulation or via the linewidth after calibration. As spin probe 13C1-PTMTC can be used to measure media microviscosity with high sensitivity. Bound to a macromolecule as spin label, 13C1-PTMTC could be used to study local mobility and molecular interactions.
Remodelling a Shp: Transmetallation in a Rare-Earth Cluster-Based Metal–Organic Framework
Authors: de Aguiar Bicalho Hudson , Donnarumma P. Rafael , Quezada-Novoa Victor , Titi Hatem M. , Howarth Ashlee J
Published: April 2021

Post-synthetic modification (PSM) of metal–organic frameworks (MOFs) is an important strategy for accessing MOF analogues that cannot be easily synthesized de novo. In this work, the rare-earth (RE) cluster-based MOF, Y-CU-10, with shp topology was modified through transmetallation using a series of RE ions, including: La(III), Nd(III), Eu(III), Tb(III), Er(III), Tm(III), and Yb(III). In all cases, metal-exchange higher than 70 % was observed, with reproducible results. All transmetallated materials were fully characterized and compared to the parent MOF, Y-CU-10, in regards to crystallinity, surface area, and morphology. Additionally, single-crystal X-ray diffraction (SCXRD) measurements were performed to provide further evidence of transmetallation occurring in the nonanuclear cluster nodes of the MOF.
Ehretia amoena Klotzsch (Ehretiaceae): Review of its medicinal uses, phytochemistry and pharmacological properties
Authors: Alfred Maroyi
Published: April 2021

Ehretia amoena is a deciduous shrub or small tree widely used as herbal medicine in tropical Africa. Ehretia amoena occurs naturally in Eswatini, Kenya, Malawi, Mozambique, Namibia, South Africa, Tanzania, Uganda, Zambia and Zimbabwe. The current study critically reviewed the medicinal uses, phytochemistry and pharmacological activities of E. amoena. Literature on medicinal uses, phytochemical and biological activities of E. amoena was collected from multiple internet sources such as Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct and Scopus. Complementary information was collected from pre-electronic sources such as books, book chapters, theses, scientific reports and journal articles obtained from the university library. This study revealed that the bark, fruit, leaf, root, root bark, stem and stem bark decoction or infusion of E. amoena are mainly used as an anthelmintic or dewormer and herbal medicine for fever, typhoid, sleeping sickness, wounds, menstrual problems, abdominal pains, sexually transmitted infections, skin diseases, vomiting, pain, muscle pain and gastro-intestinal problems. Ethnopharmacological research identified chrysosplenetin, chrysosplenol D, emodins, polyose, polyuronoids, saponins, steroids, tannins, terpenoids and volatile oils from the leaves and roots of E. amoena. The crude extracts of E. amoena and the phytochemical compounds identified from the species exhibited antibacterial, antitrypanosomal  and cytotoxicity activities. Ehretia amoena should be subjected to detailed phytochemical, pharmacological and toxicological studies.
Analisis Sentimen Mahasiswa untuk Perbaikan Desain Afektif Ruang Kelas Jurusan Teknik Industri, Universitas Trisakti
Authors: Habyba Anik Nur , Rahmawati Novia , SD Triwulandari
Published: April 2021

Improving the affective classroom design is essential to maximize student performance and learning achievement. The comfort and performance achievement of Trisakti University Industrial Engineering students are influenced by the affective design of classrooms. This study aimed to use sentiment analysis in the classification of students’ perceptions of the affective classroom design. Student sentiment classification is done using a Support Vector Machine (SVM). The questionnaire analysis results also showed perceptions about the subjects that were considered the most difficult (statistics). The classrooms had a positive sentiment: FGTSC, a sample for the next stage of classroom design formulation. The results show what impressions and things the students consider in choosing the FGTSC class. Some examples of the dominant kansei word are “comfortable,” this shows that students really care about the comfort of a classroom in the learning process. The word kansei for the design concept was collected from students' perceptions of the “positive” label. Design elements that need to be improved include equipment that is less comfortable to use, less lighting, walls with graffiti and uncomfortable seating. The classification results using three SVM types Kernel linear, radial and polynomial obtained linear have the best accuracy value (76%). These results indicate that the classification of student sentiment has the maximum results with SVM linear kernel (dot) type. This method will be used in classifying student sentiment on the results of improving classroom design.
Simulación hidrológica para sistemas de drenaje sostenible aplicada en jardines verticales en el humedal La Vaca, Bogotá D.C.
Authors: Velásquez García Edward Daniel , Forero Buitrago Gonzalo Alberto , González Angarita Gina Paola
Published: April 2021

Los Sistemas Urbanos de Drenaje Sostenible (SUDS) en la zona de influencia del humedal La Vaca son una alternativa para promover el uso eficiente del recurso hídrico. Para su simulación se proponen tres componentes principales: evaluación de las potenciales áreas de captación de agua lluvia, optimización de las condiciones de operación hidráulica para un jardín vertical en Corabastos de acuerdo a la hidrología y por último la simulación del sistema hidráulico propuesto en el software Pipe Flow Expert. Los resultados de la simulación sugieren que implementar los SUDS sobre las cubiertas de Corabastos son técnicas factibles dado que no existe ningún periodo de completa sequia durante el año en la localidad de Kennedy; esto permitirá obtener cerca de 1’537.000 litros de agua lluvia anual que podría ser aprovechada de marzo a noviembre sin déficit, cubriría las necesidades de jardines verticales en la zona y añadiría disponibilidad para otros usos. Finalmente, se concluye que este tipo de sistemas permiten mitigar las afectaciones a la infraestructura inundable con enormes beneficios sociales, paisajísticos y ecológicos.
Evaluating the level of employee engagement in strategy implementation using the Balanced Scorecard
Authors: Klinck Goitseone , Moraka Martha Esther
Published: April 2021

The term ‘employee engagement’ has been debated in human resources management, with particular emphasis on discussions centred on employee motivation, job satisfaction and productivity. Recent research shifted focus to show its significance in performance management. Research is still scanty on the linkage of employee engagement, overall organisation performance and the strategic management process. This research aimed at assessing the role of employee engagement in strategy implementation using the Balanced Scorecard for a Ministry of Minerals Resources. Knowledge of the importance of engagement in the execution of the organisation’s strategy and performance management was sought and the role of leadership in driving employee engagement in the workplace. A quantitative research strategy was used to gather data from a target population of 120 participants through the use of questionnaires. Findings revealed that awareness of the importance of engaged employees in the execution of an organisation strategy is relatively high and can positively contribute to increased productivity and performance, particularly if the Business Scorecard tool is understood by all employees and appropriately cascaded to them. The study also recommended that a positive organisational culture be cultivated so that all employees have the same vision, motivation and drive to improve productivity.
EKSISTENSI MEDIA TELEVISI ERA DIGITAL DIKALANGAN REMAJA
Authors: Haqqu Rizca , Azwar Ersyad Firdaus
Published: April 2021

Media televisi merupakan bagian yang tidak dapat terpisahkan dari kehidupan masyarakat di Indonesia. Hampir semua rumah mempunyai televisi terutama dipulau Jawa. Hasil dari beberapa lembaga riset ternama menjelaskan bahwa penggunaan media televisi masih sangat diminati dikalangan masyarakat. Akan tetapi seiring perkembangan jaman, hadirnya media baru dengan platfom digital serupa tahun ke tahun semakin meningkat dan mendominasi. Terutama dikalangan anak muda, karakter media baru yang lebih felksibel membuat keberadaan media baru tersebut semakin digandrungi. Hasil penelitian ini menunjukan bahwa adanya perubahan pola penggunaan media konvensional ditunjukan oleh hasil rendahnya tinggkat menggunaan media televisi dengan indikasi khalayak mulai beralih menonton program televisi melalui platfom digital lain seperti youtube. Dibutuhkan sinergisitas, kreatifitas, dan kualitas program yang baik agar media televisi masih dapat terus eksis menghadapi pesatnya perkembangan teknologi di era digital
Analisis Tanggapan Masyarakat Terhadap Iklan Layanan Masyarakat Dinas Dukcapil Kota Madiun
Authors: Panuju Redi
Published: April 2021

Tujuan Penelitian ini untuk mengetahui tanggapan Khalayak terhadap program Dukcapil Keliling Kota Madiun. Dukcapil merupakan salah satu program pemerintah Kota Madiun dalam pelayanan administrasi kependudukan. Program Pelayanan melalui channel youtube.com dengan tajuk Dukcapil Keliling Kota Madiun yang dalam penelitian ini dilakukan uji ukur tingkat daya tarik pada aspek isi informasi dan bantuk iklan terhadap tanggapan masyarakat untuk memanfaatkan program tersebut. Penelitian ini menggunakan data kuantitatif dengan berdasar studi kasus di lapangan. Berdasarkan hasil uji hipotesis pertama, dinyatakan bahwa hasil statistik uji regresi dengan nilai thitung sebesar 3,034 dengan nilai signifikansi sebesar 0,003 lebih kecil dari 0,05 (Sig. < 0,05), dan koefisien regresi mempunyai nilai positif sebesar 0,265; maka hipotesis pertama dalam penelitian ini terbukti yaitu daya tarik isi informasi memiliki pengaruh yang positif terhadap tanggapan masyarakat untuk mengunakan layanan tersebut. Hasil statistik uji regresi pada hipotesis kedua, nilai thitung sebesar 3,795 dengan nilai signifikansi sebesar 0,000 lebih kecil dari 0,05 (Sig. < 0,05), dan koefisien regresi mempunyai nilai positif sebesar 0,332; maka hipotesis kedua dalam penelitian ini terbukti yaitu daya tarik bentuk iklan memiliki pengaruh yang positif terhadap tanggapan masyarakat untuk mengunakan layanan tersebut. Untuk hasil uji hipotesis ketiga, diperoleh nilai Fhitung sebesar 14,906 dengan signifikansi sebesar 0,000. Oleh karena nilai signifikansi lebih kecil dari 0,05 (Sig.<0,05),  maka dapat disimpulkan bahwa hipotesis ketiga dalam penelitian ini terbukti yaitu daya tarik isi informasi dan bentuk penyampaian iklan memiliki pengaruh yang positif terhadap tanggapan masyarakat pada ILM Dukcapil Keliling Kota Madiun. 
IMPLEMENTASI SISTEM VOUCHER DENGAN ROUTER MIKROTIK
Authors: Adhiwibowo Whisnumurti , Mindatama Wijatmoko
Published: April 2021

Voucher system is a feature owned by Mikrotik to facilitate network administrators to manage access on the router based on bandwidth allocation, website filtering and access time settings. This final project will be implemented voucher system at PT. Tunggul Sakti Sejahtera. The number of employees is approximately 25 employees at headquarters who own a smartphone and connect to the company's Access Point. Bandwidth allocation, website filtering and access time setting for each employee can not be limited. To solve the problem, the authors plan to implement a voucher system on the network of PT. Tunggul Sakti Sejahtera.Implementation method of voucher system used is CISCO Network Cycle PPDIOO method has Prepare, Plan, Design, Implement, Operate, and Optimize. Implementation of voucher system at PT. Tunggul Sakti Sejahtera uses router Mikrotik Routerboard 750 series and D-Link access point as a repeater device. Voucher system can optimize network management at PT. Tunggul Sakti Sejahtera so it can facilitate network administrator in managing computer network. Documentation of system is done periodically, if the system crashes it can be restored
Aplikasi Identifikasi Jenis Buah Kurma Dengan Metode GLCM Berbasis Android
Authors: Fandi Mochamad
Published: April 2021

Buah kurma merupakan salah satu buah yang sangat populer di Indonesia. Ada banyak sekali jenis kurma yang dijual di pasaran, oleh karena itu konsumen mengalami kesulitan dalam mengenali tiap jenis kurma. Hal tersebut sering dimanfaatkan oleh penjual kurma untuk melakukan kecurangan dengan mencampurkan kurma Ajwa dengan kurma jenis lain. Tujuan dari penelitian ini adalah untuk menghasilkan aplikasi bergerak yang dapat mengidentifikasi jenis kurma Ajwa, kurma Sukari, dan kurma Deglet Nour. Aplikasi dibangun menggunakan Android Studio dan OpenCV sebagai library untuk proses pengolahan citra. Tahapan proses pengolahan citra terdiri atas pra pengolahan citra aras kebuan, metode segmentasi pengambangan, dan ekstraksi ciri statistik orde kedua dengan metode GLCM. Hasil dari penelitian ini didapatkan tingkat keberhasilan sebesar 83,33% yang menggunakan 90 citra data latih dan 30 citra data uji.
A Literature Review of the Effects of PCOS on Cardiovascular Health
Authors: Mundle Kshitija , Raza Zoha
Published: April 2021

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder found in individuals with female reproductive organs. It is known to cause excess production of androgens, which leads to a wide variety of issues, ranging from complications with bodily function and changes in physical appearance. This review will specifically focus on the relationship between PCOS and its effects on cardiovascular health to understand the long-term implications of the disorder. The variety of treatments used for PCOS and how they affect cardiovascular health will also be explored.
Methods: Research over a span of 30 years was compiled to examine the effects of PCOS on women’s cardiovascular health outcomes.
Results: The findings support that there is indeed an adverse relationship between PCOS and cardiovascular health; however, treatments are available to combat these effects. PCOS has a negative influence on the health of the cardiovascular system; it increases the risk of hypertension and blood vessel/artery damage, metabolic disturbances such as diabetes, dyslipidemia, and insulin resistance, and has negative implications (undesirable effects) on hormones, such as insulin and androgen levels. There are multiple interventions ranging from oral contraception (OCP), lifestyle changes, and herbal medications that can reverse the effects of PCOS on the cardiovascular system. Due to the nature of PCOS, however, the results of the studies examined in this review are not an exact prospect for every affected individual and will require extensive research. Furthermore, more research is required to continue to understand other biological factors in this relationship, as well as looking into social determinants that may enhance or alter these results.
Conclusion: Ultimately, this review intends to promote further studies of the long-term effects of this hormonal disorder. Further research will not only improve the current treatment processes but may also benefit the conversation around this topic so that those who do struggle with PCOS can be more cognizant of its potential health outcomes.
Associated Factors with Hypnobirthing Implementation in Trimester III Pregnant Women at Diana Panitra Clinic Medan in 2020
Authors: Syafitri Endryani , Mardha Muthia Sari
Published: April 2021

Almost all maternal experienced anxiety and fear during pregnancy, labor, and after childbirth. One of the methods is used to reduce childbirth anxiety namely hypnobirthing. The purpose of this study was to determine the factors associated with the implementation of hypnobirthing in third trimester pregnant women at the Diana Panitra Clinic Medan in 2020. The design of this study used an analytic survey with a cross-sectional approach. The population of the study were all 30 third trimester pregnant women, and sample using accidental sampling techniques. The independent variables in this study are knowledge, husband's support, distance from facilities, and mother's interest. The instrument used a questionnaire. The data analysis technique used univariate and bivariate analyses. The results showed that there is a relationship implementation of hypnobirthing between knowledge with p-value (sig) = 0.044, husband's support with p-value (sig) = 0.004, facility distance and p-value (sig) = 0.019, and maternal interest with p-value (sig) = 0.015. The conclusion of this study is that there is a relationship between knowledge, husband's support, the distance of facilities, and mother's interest with the implementation of hypnobirthing in trimester III pregnant women at the Diana Panitra Clinic Medan in 2020. And it is hoped that health workers will participate in providing information about the benefits of hypnobirthing during pregnancy.
Factors Associated with Psychological Health Issues in Diploma Nursing Students: A Cross-sectional Study
Authors: Kai Li
Published: April 2021

Psychological health is the expression of harmonic, expression of human personality, and is often disrupted by multiple factors. The aim of this study is to assess psychological health status and its associated factors among diploma nursing students. A cross-sectional study design was employed. The sample comprised 542 nursing students attending this anonymous survey by completed The Symptom Checklist 90 questionnaire. Descriptive statistics and logistic regression analysis were attempted to analyze overall data. The positive rate of psychological symptoms of diploma nursing students is 20.9%; the total score of SCL-90 and the scores of each factor are higher than the national norm; grade, personality, number of friends, parenting style, love experience. Whether single children and physical exercise are influential main factors of the mental health status of diploma nursing students. The contribution of Emotional Intelligence and Spirituality are crucial to the acquisition of well-being, happiness and meaning in life.
Developing a Method for Evaluating Global University Rankings
Authors: Gadd Elizabeth , Holmes Richard , Shearer Justin
Published: April 2021

Describes a method to provide an independent, community-sourced set of best practice criteria with which to assess global university rankings and to identify the extent to which a sample of six rankings, Academic Ranking of World Universities (ARWU), CWTS Leiden, QS World University Rankings (QS WUR), Times Higher Education World University Rankings (THE WUR), U-Multirank, and US News & World Report Best Global Universities, met those criteria. The criteria fell into four categories: good governance, transparency, measure what matters, and rigour. The relative strengths and weaknesses of each ranking were compared. Overall, the rankings assessed fell short of all criteria, with greatest strengths in the area of transparency and greatest weaknesses in the area of measuring what matters to the communities they were ranking. The ranking that most closely met the criteria was CWTS Leiden. Scoring poorly across all the criteria were the THE WUR and US News rankings. Suggestions for developing the ranker rating method are described.