bluuebunny/crossref_metadata_2025 huggingface dataset:
The prevalence of SARS-CoV-2 in sewage waste water: A review
Authors: Kumar Rupak , Saha Anuradha
Published: September 2021

Since one and half years, the pandemic of SARS-CoV-2 virus (disease caused is Covid-19) has ruined the entire humanity in unimaginable ways, whether it is economy or unemployment or children mental health disorder or large number of deaths. There is no country in the world which is not affected by this virus. In some countries, this pandemic is coming in the form of outbreak such as first wave of pandemic then after some gap period, second wave of pandemic. In country like India, the second wave of corona pandemic has crippled the economy, public health safety and at the same time put a big question on the health infrastructure of entire nation whether it is availability of oxygen cylinders, or testing facility, hospital bed or ventilators. The actual number of patients who can get affected had not been estimated correctly. This poses more problems due to asymptomatic nature of the expression of COVID-19 on individual basis. Tragically, for developing countries like India with high population density, the situation has been more complex. Additionally, more amount of waste from the Covid affected population goes to effluent water, waste water coming out of residential area, hospitals, isolation centres and so on. In this review article, we have focused on presence of corona virus and infection transmission through effluent water in country like India with huge number of population and also provide further scope in research to inform future studies.
To determine antimicrobial susceptibility and biofilm production among coagulase negative staphylococci at a tertiary care hospital
Authors: Bathala Naga Sri Latha , Sasidhar M , Bai S Kusuma
Published: September 2021

CoNS are gaining importance due to increase in resistance rates to betalactam antibiotics and multi drug resistance. Although specific virulence factors are not as clearly established, it seems clear that factors such as bacterial polysaccharide components, and ability to form biofilm are involved in attachment and/or persistence of bacteria on foreign materials. Biofilms usually result in persistent infections that cannot be easily resolved with standard antibiotic treatments; therefore, the biofilm formation ability and the resistance to antimicrobial therapy can be intimately related.

A prospective cross-sectional study was done on purely isolated CoNS from various clinical samples from both out patients and inpatients. All the test strains were subjected to antimicrobial susceptibility testing. The ability to produce biofilm was detected by tube adherence method.

Among 193 CoNS isolates 156 were from inpatients and 37 were from out patients. Methicillin resistant was seen in 80.31%. Of the total, 40.41% showed moderate biofilm formation by tube adherence method. 23.32% of isolates did not form biofilm. All the isolates from blood samples showed moderate (20/26) and strong (6/26) biofilm formation. Among non biofilm producers 66.67% were MS CoNS isolates and 33.33% were MRCoNS. 94.59% of biofilm producers were MRCoNS and 5.41% were MSCoNS. Production of biofilm was relatively more (1.16) among CoNS isolates of IPD than OPD.

 As Coagulase negative Staphylocooci are exhibiting multi drug resistance and are able to form biofilm, these organisms causing a major challenge for the physicians. Hence, such problems can be prevented by detection of biofilm producers and appropriate antibiotic doses modification. The issue of antibiotic resistance among CoNS needs to be addressed through a more rational use of existing antibiotics as well as the development of new antimicrobial agents.
Antinuclear antibody patterns by indirect immunofluorescence test: An experience from a rural tertiary health centre of Puducherry, South India
Authors: Ranganathan Udhayasankar , Rangasamy Gopal , Thiyagarajan Mangaiyarkarasi , Shivekar Sunil
Published: September 2021

Anti-nuclear antibodies (ANA) are known to be associated with autoimmune diseases and most commonly with connective tissue diseases (CTD). Screening for ANA is the first investigation of choice in the diagnosis of autoimmune diseases and indirect immunofluorescence (IIF) test using Hep-2 cells has been considered the gold standard method. The prevalence of autoimmune diseases and hence the ANA positivity and ANA IIF patterns differ in various geographical regions.

This study was aimed to estimate the ANA positivity rates among patients with suspected or confirmed auto immune diseases and to determine the common ANA IIF patterns in the positive samples.

: This is a retrospective study including 235 patients with either clinical suspicion of, or suffering from autoimmune diseases attending a tertiary health care hospital in Puducherry, South India, between November 2018 and April 2020. ANA IIF test (Hep 20-10/ primate liver, Euroimmun, Germany) was performed with 1:100 dilutions of patient serum.

The ANA positivity rate was 14.5% (34 out of 235 samples were positive). ANA was positive in 10 (13.3%) males and 24 (15%) females. The mean age of ANA positive patients were 43.4 years.The most common pattern was nucleus fine granular (n=8) followed by cytoplasm fine granular (n=7) and centromere (n=4).

A significant ANA positivity rate was found in our study and a detailed clinical study has to be conducted to draw further conclusions.
Depresión en estudiantes universitarios derivada del Covid-19: un modelo de clasificación
Authors: Quintero López Catalina , Gil Vera Victor Daniel
Published: September 2021

Las estrategias gubernamentales adoptadas a nivel mundial como medida de prevención frente a la emergencia sanitaria generada por el COVID-19, han despertado el interés de la comunidad científica por conocer los efectos de las mismas sobre la salud mental.  El objetivo de esta investigación fue desarrollar un modelo de clasificación para pronosticar depresión en estudiantes universitarios por factores de estrés asociados a la pandemia. Se desarrolló un Modelo de Clasificación con Árboles de Decisión (MCAD) a partir de los resultados de una encuesta de percepción con preguntas tipo escala Likert, la cual fue aplicada a una muestra de 833 estudiantes universitarios de diferentes programas académicos de Colombia. La variable dependiente del modelo fue la presencia o ausencia de depresión, y las respuestas de 700 estudiantes se emplearon para el entrenamiento y 133 para la prueba. Se concluye que el MCAD es válido para pronosticar depresión; tuvo una tasa de precisión del 87% en la muestra de prueba. Finalmente, se halló que los factores que más influyen en el desarrollo de estados depresivos en el contexto de la pandemia generada por el COVID-19 en estudiantes universitarios son: estado civil, sexo, edad, problemas educativos e información proveniente de los medios de comunicación.
Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms
Authors: Hentilä Jessica , Laakamaa Noora , Sorsa Timo , Meurman Jukka , Välimaa Hanna , Nikinmaa Sakari , Kankuri Esko , Tauriainen Tuomas , Pätilä Tommi
Published: September 2021

Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients.  We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.
Bovine Herpesvirus Types 5 (BoHV5): A New and Emerging Threat in Indian Cattle
Authors: Rawat K.D. , Chaubey K.K.
Published: September 2021

Bovine herpesvirus 5 (BoHV-5) belongs to the genus varicellovirus family herpesviridae and is a causative agent of meningo-encephalitis in cattle. BoHV-5 can replicates in the central nervous system (CNS) to cause encephalitis and establishes latency in the trigeminal ganglion of either naturally infected cattle or experimentally inoculated laboratory animals. BoHV 5 was first time reported in Australia in 1962 and subsequently reported in Latin Ameican countries Argentina, Brazil and Uruguay. Few cases of BoHV5 infection has also been reported in USA and Europe. Recently, the BoHV5 infection was reported in Indian cattle for the first time. The BoHV5 was isolated from aborted cattle and characterized as BoHV5 subtype A and this finding may necessitate inclusion of BoHV5 test protocol in testing of semen for sexually transmitted diseases. Because BoHV5 infection in cattle recently reported in India so, it is needed to explore the similarity of the isolates with earlier reported isolates and to check it’s pathogenicity to cause encephalitis in natural host and in experimental animals like rabbits, rat, guniea pig etc. Beside this, we have to explore the information about co-infection of BoHV5 with other viral, bacterial, fungal as well as parasitic agents.
Study of the Antibacterial and Antioxidant Capacities of Fixed Oil of Moringa oleifera L. Cultivated in the Southwest of Algeria
Authors: Boulal A. , Ouafiane A. , Oubiri M. , Ladjel S.
Published: September 2021

Background: Since time immemorial, humans have always been interested in lipids for various uses, namely food, cosmetology, medicine, etc. Many seeds, sources of oils, are increasingly studied for their nutritional and therapeutic properties. Methods: The present study aims to valorize the vegetable oil obtained from the seeds of the Moringa oleifera plant widely cultivated in the southwest of Algeria, using the solid-liquid extraction technique. In addition, the fatty acid analysis of this oil, using the gas chromatography technique. Result: An oil yield of 30.43% was obtained, revealed that it contains ten different compounds. The characterization of the oil obtained (physico-chemical properties such as organoleptic properties, density, viscosity, refractive index) proved to comply with international standards and AFNOR standards. In addition, it turned out that Moringa oleifera oil has a very interesting antioxidant power. However, this oil did not show any antibacterial activity on the strains tested.
Analysis of the Non-genetic Factors Influencing the Performance of High-grade and Inter se Mated Crossbred Dairy Cows at Holetta Dairy Research Farm, Ethiopia
Authors: Tadesse Million , Getahun Kefale , Hunde Direba , Gelmessa Ulfina
Published: September 2021

Background: The effect of non-genetic factors including feeding, management, climate, calving year, season and others on animal production improvement has attracted considerable attention in recent years. In addition to improving animal genetics, the importance of optimum environmental conditions in enhancing animal production is recognized. Methods: Data collected from 2008 to 2018 on 2036 records from crossbreeding dairy cattle herd at Holeta Agricultural Research Center were analyzed to evaluate the genetic and non-genetic environmental effect on lactation milk yield (LMY), lactation length (LL) and calving interval (CI). The fixed effect used in the data analysis were breed group, parity, years group of calving and seasons of calving. GLM procedure of SAS was used to analyze the data. Result: Results of data analysis indicated that breed group and year group of calving had a significant (P less than 0.05) effect on LMY, LL and CI. Parity significantly (P less than 0.05) affected LMY and CI but had no significant effects on LL. While, season of calving had no significant influence on all traits. Least square mean LMY was significantly (p less than 0.05) highest (3191 kg) for 75% first generation breed group and significantly (P less than 0.05) lowest for pure Ethiopian Borena breed (124 kg LMY). Mean LL was significantly (p less than 0.05) highest (354 days) for 75% first generation breed group and significantly (P less than 0.05) lowest for pure Ethiopian Borena breed (178 days). Least square mean CI was significantly (p less than 0.05) longest (477 days) for 75% first generation breed group and significantly (P less than 0.05) shortest (422 days) for 75% inter se mated breed group. Among 75% crosses, the 75% inter se mated breed group had lower LMY (2553 kg) and shorter CI (422 days) compared to 75% first generation breed group. The decline in LMY and CI for 75% inter se mated breed group by 637 kg (25%) and 54 days (13%), respectively compared to 75% first generation, which can be attributed to recombination effect.
Determination of the Best Method of Dehydration of Tropical Fruits to be Incorporated in Gelatin-based Dessert with Unaltered Sensory Qualities
Authors: Perera Poorna
Published: September 2021

Background: Jelly based desserts are very popular among millions of people worldwide. The main gel forming ingredient used in these products is ‘Gelatin’, which is a complex polysaccharide in their chemical structure. This research study focusses on incorporation of fruit pieces in to the dessert jelly in order to give a novel experience to the consumers. Methods: To determine the best way of incorporating fruit pieces in a commercially available jelly mixture (which is made up of fruit flavour, acid, water, sugar and pectin as the jelling agent), fruit pieces were treated in two ways and compared for the best textural and sensory qualities. First sample constituted unblanched, oven dried fruit pieces in a commercially available jelly mixture and its was compared with a jelly sample with blanched (fruit pieces were pretreated to minimize any possible discolorations and textural changes), osmo air dehydrated and oven dried fruit pieces. Sensory qualities such as texture, mouth feel and flavour of two different samples were gauged through a sensory test. Result: From a sensory test carries out by a panel of 09 sensory panelists it was found that the jelly mixture when incorporated with osmo air dehydrate fruit pieces it did not degrade the texture of the final product as opposed to unblanched dried fruit pieces does. The osmo air dehydrated fruit pieces in the prepared jelly has a texture and an acceptable mouth feel which is closer in texturally to the natural mouth feel and the taste, when they are reconstituted inside the jelly mixture by absorbing the water from the mixture.
Endoscopic treatment of subglottic stenosis in children
Authors: Komina E. I. , Alkhasov A. B. , Rusetsky Yu. Yu. , Lokhmatov M. M. , Yatsyk S. P. , Ratnikov S. A. , Romanova E. A. , Savelyeva M. S.
Published: September 2021

Introduction. Subglottic stenosis is one of the most common causes of upper airway obstruction. The incidence of post-intubation stenosis ranges from 0.9% to 3% (Rodríguez H. et al.), or from 0.2% to 20% (Haranal M.Y. et al.). Currently, there is no consensus on the choice of surgical tactics due to a large number of modalities for surgical restoration of the laryngeal lumen.Material and methods. 44 patients with postintubation laryngeal stenosis were treated in the surgical thoracic department of the National Medical Research Center of Children’s Health subordinate to the Ministry of Health of the Russian Federation during 2019-2021. The average age of patients in this group was 4 years 8 months ± 3 years 8 months. Endoscopic treatment was done to 24 patients (54.5%). Laryngoscopy, fibrobronchoscopy, multispiral computed tomography and, if necessary, barium esophagogram were done for additional diagnostics.Results. The average number of endoscopic procedures per patient was 2.9 ± 1.5 (range from 1 to 7). Good results were seen in 20 patients (83.3%).Conclusions. Endoscopic techniques are alternative options to open reconstructive surgery. These techniques give good results in treating stenoses in the subglottic space and give a good chance to avoid tracheostomy in a certain group of patients, which, according to the results of our study, was as large as 79.1%.
La traduction sert-elle à propager les connaissances en traductologie ? Études des cas grec et polonais
Authors: Pantazara Mavina , Skibińska Elżbieta
Published: September 2021

The aim of this paper is to examine the factors that may boost or hinder the effectiveness of translation as a vehicle of knowledge dissemination. The analysis was based on bibliographical data concerning the translations of books of all kinds (monographs, handbooks, textbooks, anthologies, etc.) in the field of translation Studies, which have been published in Greece and Poland. Both countries can be considered as being on the periphery of Europe on the basis of geographical, political, economic, linguistic, and cultural criteria. In both countries, the number of these translations is actually very small (about 20 in each of them), and the number of their source languages is extremely limited (mostly English, rarely French or German). However, the different organization of their universities and academic research shapes not only how the individual translation training and scientific work on translation are developed, but also how these translations are embedded in university syllabi. The analysis of the data leads to confirming the dominance of English as the translation studies language and suggests a necessity to reconsider the notions of centres and peripheries in this particular field of research and the role of translation in their relationship.
Fuir la périphérie, ou comment la Pologne a voulu créer son image dans le premier, le second et le tiers monde. Étude des traductions des mensuels « La Pologne », « Polsko » et « La Revue Polonaise » en 1968
Authors: Solová Regina
Published: September 2021

The paper deals with the image strategies of People’s Poland as a peripheral country based on an analysis of the elements of its foreign cultural policy carried out through translations in 1968. The quantitative and qualitative analysis of the content of the three versions of the review Polska. Czasopismo Ilustrowane [Poland. Illustrated Magazine], created to promote Poland in the world, is based on P. Bourdieu’s concept of capital. We start from two hypotheses: the first one about the valuation of cultural capital in the versions of the review addressed to capitalist (La Pologne. Revue Mensuelle) and socialist (Polsko. Obrázkový časopis) countries. The second — on the promotion of Poland’s economic and political capital in the version for “third world countries” (La Revue Polonaise. Magazine Illustré). Generally, both hypotheses are confirmed. The analysis also shows variations of the image strategies depending on the target readers: westernisation (emphasis on cultural ties to the West) and victimisation (Poland as a victim of history) in the version for the “first world”; strategy of utopia (emphasis on the achievements of a socialist country) in the version for the “second world”; idealisation (Poland as a peaceful, economically developed country) in the “third world” version. These strategies correspond to the key word of the political elites’ policy, “fleeing the periphery”.
Les langues « au centre » et les langues « périphériques » dans l’Union européenne multilingue : implications sur la formation des traducteurs et sur les traductions
Authors: Tomaszkiewicz Teresa
Published: September 2021

The European Union is by definition a multilingual organization in which the official languages of all members are recognized equally. The translation system in this organization is highly developed. Political correctness wants to give the impression that every European citizen can communicate in his mother tongue without barriers or limits. However, practice shows that in many cases this principle does not correspond to reality. In this article the author shows, on the basis of quantitative and qualitative analysis of the working languages, which are offered by translator training programs belonging to the EMT (European Master’s in Translation) network, that there is a clear difference between the status of “central” languages, dominant in communication, and the so called “peripherals”, of less diffusion. This situation has an impact on the volume and number of translations, their direction, and, consequently, on the translators’ training.
Du gommage de l’infinitif dans la traduction polonaise de l’Infinitive de Compte rendu de Perception (ICP) : entre grammaire, style et représentation de la réalité
Authors: Ucherek Witold , Marsac Fabrice , Dańko Magdalena
Published: September 2021

The study subject are Polish translations of the French structure NP1 + voir + NP2 + infinitive; we reject cases where the NP1 is represented by the pronoun on, and concentrate on translations in which the infinitive is not rendered. The analysis is based on the corpus of texts embracing 58 pairs of examples, each of which contains a French sentence with the investigated construction and a Polish sentence with its equivalent. Our aim is to identify factors which make translators erase the French infinitive. The conducted analysis reveals that the avoided infinitives belong to two groups: appearance verbs and dynamic position verbs; the most frequent are surgir (‘appear suddenly’), arriver (‘arrive’) and passer (‘pass’). The main reason for their avoidance is the stylistic one.
Communication en langues étrangères avec les visiteurs d’un lieu de mémoire : un sujet périphérique des études de traduction
Authors: Chrobak Marzena , Paleczna Marta
Published: September 2021

After some general remarks on a contemporary basic map of Translation Studies, we present the results of a research on a peripherical topic in the field Interpretation Studies: interpreting in a museum setting. The museum concerned is the Auschwitz-Birkenau State Museum, a former nazi concentration and extermination camp situated in Poland, a World Heritage Site, and a symbol of the Holocaust. The research is based on surveys conducted in 2017 and 2018 by Marta Paleczna among the camp’s visitors, guides, and interpreters. We discuss the interpreters’ main problems, which include translating camprelated and other specific terms, collaboration with a guide, the increasing number of visitors and time constraint, and their solutions, which include compressing the explanations given by a guide during the visit, taking over the role of a guide by the interpreter, and lengthening the explanation time by taking advantage of the trip to the museum and back.
Centres vs périphéries dans l’espace traductionnel hellénophone : modes de croisement et types de relations
Authors: P. Grammenidis Simos
Published: September 2021

Despite being almost nonexistent as an activity during Antiquity, translation occupies an essential position in the formation and development of the Greek language, in the cultural growth and even the awakening of the enslaved nation between the 15th and the early 20th centuries.
The aim of this paper is to present the particularities of the Greek-speaking translational domain as well as the types of relationships established within the international context since the 17th century. Furthermore, the author studies whether the objectives of the translated text are identical to those of the original text, and if the translation methods adopted by the Greek-speaking world are the same as those adopted elsewhere. Finally, the author attempts to sketch the contribution of the international context to the local translational thinking.
Current Status and Challenge for Implementation in Clinical Application of Augmented Reality in Orthopedics Department at a Medical Center
Authors: Chiu Hsiao-Hui , Wei Pi-Ching , Lin Man-Ling , Chen Yi-Chun , Chou Shu-Yuan , Yao Yu-Cheng , Yang Ying-Ying
Published: September 2021

With technical development, artificial intelligence (AI) has been actively involving in the healthcare industry. Augmented reality (AR) is an interactive experience with the combination of virtual objects and a real-world environment, and the objects reside in the environment of the real world through computer-generated images for the purpose to enhance perceptual effects, which can be applied in the fields of medical education and clinical practice. Researchers have found that learning motives and interests may be raised by AR. At a medical center, the inter-specialty team from the Teaching Department and Rehabilitation Department jointly developed an AR Medical Education App, which involves 44 muscle strength and walking exercises, including 6 upper limb movements, 28 lower limb exercises, and 10 cardiorespiratory exercises. Various exercise packages can be designed by health caregivers based on patient’s needs in exercise. The Orthopedics Ward applied it in the respiration training for patients who underwent spinal surgery, preventing respiratory comorbidities. The improved postoperative pulmonary function has been found when compared with that before surgery, with statistical significance. Respiration, upper and lower limbs exercises were persistently performed in patients who underwent spinal surgery, which also has been incorporated in routine nursing care to add diverse options of patient education materials for nursing personnel. In the future, aspects that required further efforts include: expanded software equipment, simplified operation mode, increased user-friendly features for equipment, and expended plentifulness of contents.
Development of Siberian Branch of the Russian Academy of Sciences scientific book publishing system (2001–2010)
Authors: Panchenko A. M. , Timofeeva Yu. V.
Published: September 2021

The study of scientific book publishing, due to its enormous social and state significance, is an urgent task of modern research. This article is the first to consider the system of scientific book publishing in the Siberian Branch of the Russian Academy of Sciences (SB RAS) in the period of 2001–2010 thus determining and adding to the history of regional and Russian scientific book publishing. The purpose of the study is to present the development of the system for publishing scientific literature in the SB RAS during this period. The source base of the study is representative: these are numerous documents of the current archives of the Siberian enterprise “Nauka” RAS (Novosibirsk Printing House No. 4) and the Siberian Publishing Company “Nauka” RAS, regulatory acts of the Presidium of SB RAS, Annotated thematic plans for the release of scientific literature for 2002-2010, Publishing houses of SB RAS, materials of the weekly newspaper SB RAS “Science in Siberia” for the same period.

The revealed data allow reconstructing the picture of the scientific book publishing system development in SB RAS and its thematic orientation in the first decade of the XXI century. The results obtained show that the prevailing part of published scientific literature – every third edition – during this period was on archeology, history, philology, philosophy, law.

The study refined quantitative data on the release of serial publications, revealed the role of the Presidium SB RAS in developing the system of scientific book publishing, expanded the idea of cooperation between SB RAS and SIF “Nauka” RAS.

The results obtained provide an opportunity to redefine and assess the evolution of their relationship during the period under review. The continuing decrease in the share of CIF in the total volume of publications of SB RAS can be interpreted as the crisis increase, but the implementation of significant and complex publishing projects speaks for a new paradigm of relations between them: mutually beneficial, effective and promising.
The Solar System
Authors: Ljubičić Mario
Published: September 2021

Origin, mechanics and properties of the Solar System are analyzed in the framework of Complete Relativity. The analysis confirms the postulates and hypotheses of the theory with a high degree of confidence. During the analysis, some new hypotheses have emerged. These are discussed and confirmed with various degrees of confidence. To increase confidence or refute some hypotheses, experimental verification is necessary. Main conclusions are: - Solar System is a scaled Carbon isotope with a nucleus in a condensed (bosonic) state and components in various vertically excited states, - Earth is a living being of extremely introverted intelligence, life is common everywhere, albeit extroverted complex forms are present on planetary surfaces only during planetary neurogenesis, - anthropogenic climate change is only a part (trigger from one perspective) of bigger global changes on Earth and in the Solar System during planetary neurogenesis, - major extinction events are relative extinctions, a regular part of transformation and transfer of life in the process of planetary neurogenesis
Identifying Complex lncRNA/Pseudogene-miRNA-mRNA Crosstalk in Hormone-Dependent Cancers
Authors: Jayarathna Dulari , Rentería Miguel E. , Sauret Emilie , Batra Jyotsna , Gandhi Neha S.
Published: September 2021

The discovery of microRNAs (miRNAs) has fundamentally transformed our understanding of gene regulation. The competing endogenous RNA (ceRNA) hypothesis postulates that not only messenger RNAs but also other RNA transcripts, such as long non-coding RNAs and pseudogenes, can act as natural miRNA sponges. These RNAs influence each other’s expression levels by competing for the same pool of miRNAs through miRNA response elements on their target transcripts, thereby modulating gene expression and protein activity. In recent years, these ceRNA regulatory networks have gained considerable attention in cancer research. Several studies have identified cancer-specific ceRNA networks. Nevertheless, prior bioinformatic analyses have focused on long non-coding RNAs-associated ceRNA networks. Here, we identify an extended-ceRNA network (including both long non-coding RNAs and pseudogenes) shared across a group of four hormone-dependent (HD) cancers, i.e., prostate, breast, colorectal, and endometrial cancers, using data from The Cancer Genome Atlas (TCGA). We performed a functional enrichment analysis for differentially expressed genes in the shared ceRNA network of HD cancers, followed by a survival analysis to determine their prognostic ability. We identified two long non-coding RNAs, nine genes, and seventy-four miRNAs in the shared ceRNA network across four HD cancers. Among them, two genes and forty-one miRNAs were associated with at least one HD cancer survival. This study is the first to investigate pseudogene associated ceRNAs across a group of related cancers and highlights the value of this approach to understanding shared molecular pathogenesis in a group of related diseases.
Structure of polytetrafluoroethylene modified by the combined action of γ-radiation and high temperatures
Authors: Smolyanskii Alexander Sergeevich , Politova Ekaterina Dmitrievna , Koshkina Ol'ga Alekseevna , Arsentyev Mikhail Aleksandrovich , Kusch Pavel Prokof'evich , Moskvitin Lev Vladimirovich , Slesarenko Sergei Vital'evich , Kiryukhin Dmitrii Pavlovich , Trakhtenberg Leonid Izraiilevich
Published: September 2021

By means of X-ray computed microtomography (XCMT) the existence of a developed microporous structure having an average pore diameter of ~3.5 μm and pore content of ~1.1 vol.% has been revealed in unirradiated polytetrafluoroethylene (PTFE). It has been found that the combined action of gamma radiation (absorbed dose per PTFE of ~170 kGy) and high temperatures (327-350 °C) leads to the disappearance of the microporous structure and the formation of several large pores with sizes from 30 to 50 μm in the bulk of thermal-radiation modified PTFE (TRM-PTFE). It has been established by X-ray diffraction (XRD) analysis that the thermal-radiation modification of PTFE leads to an increase in the interplanar spacings, the degree of crystallinity and volume of the unit cell, as well as to a decrease in the size of crystals and the X-ray density of the crystalline phase in comparison with the initial polymer. It is assumed that the previously established effect of improving the deformation-strength and tribological properties of the TRM-PTFE can be due not only to the radiation cross-linking of polymer chains but also to the disappearance of the micropore system and to the ordering of the crystalline phase of PTFE.
Neonatal Pneumothorax- Five Years of Experience in a Tertiary Care Center
Authors: Jovandaric Miljana Z , Milenkovic Svetlana J , Babovic Ivana R
Published: September 2021

I Introduction: Pneumothorax is a pathological condition characterized by the presence of air between the visceral and parietal pleura. Objectives: To investigate incidence, clinical characteristics, risk factors, management and perinatal outcome among newborns with pneumothorax in a tertiary care center. Materials and Methods: A prospective observational study was conducted in Maternity hospital with tertiary NICU from 2015-2019. We included all neonates with pneumothorax born in our hospital and compared demographic characteristics, perinatal risk factors, anthropometric parameters, concurrent diseases, clinical course and method of chest drainage between full term (≥37 GW) and preterm (<37GW) newborns. Results: Mong 30.378 neonates, 74 developed pneumothorax (2, 4/1000 newborns). The incidence of neonatal pneumothorax (NP) was higher in preterm group (59, 5%), with a mean age 34,62 GW in whole group. The mode of delivery was c. section in 68.9%. NP occurred mostly on the right side (47,3%), on the second day of life , in males (67,6%). Chest drainage was performed in 64,9% of cases. Of 74 NP cases, 64 (85.1%) recovered, 6 (8,1%) died. Conclusion: Pneumothorax is a pathological condition of the newborn, which, if not diagnosed in time and treated adequately, leads to a fatal outcome.ads to a
New Formula for the Identification of Liquefaction Based on the Investigation of the Songyuan Site
Authors: Li Ping , Zhang Yuan , Zhang Yudong
Published: September 2021

Based on the 5.7-magnitude earthquake that stroke Songyuan (China) and 172 groups of liquefaction data collected in mainland China, the hyperbolic liquefaction discriminant formula originally proposed by Sun Rui was revised, and a new formula for the liquefaction of sand was put forward. Groups of data derived from the Bachu earthquake in Xinjiang and an earthquake that occurred in New Zealand (47 and 195 groups, respectively) were used to carry out a back-judgment test, then, the results were compared with those of the existing standard method. Overall, the results showed that the new formula for hyperbolic liquefaction discrimination compensates for the conservative liquefaction discrimination of the older formula; moreover, it has a good applicability to different intensities, groundwater levels, and the deep sand layer of the Songyuan site, reflected by a more balanced success rate. Therefore, combining the existing liquefaction discrimination methods and the research results of discrimination, it is necessary to establish a suitable regional identification method through the continuous accumulation of liquefaction data and expanding database.
RELAÇÃO DOS EFEITOS PERCEPTIVOS DA CORRUPÇÃO
Authors: Petry Jonas Fernando , Barbosa Rodrigo Noronha , Assis Sabrina Neves , Uchôa Antônio Giovanni Figliuolo
Published: September 2021

O artigo tem como objetivo fornecer evidências empíricas da relação da corrupção nas instituições públicas do país e seus efeitos na imagem e na qualidade percebida do aparato público. Através de uma análise multivariada com 626 respondentes, o modelo conceitual é testado. Como esperado, a corrupção não é um ato consuetudinário, é perverso e não traz efeitos positivos para o país, comprometendo a reputação, a competência e, principalmente, acarretando a perda da confiança na democracia, o desinteresse pela política e a desconfiança em relação às instituições públicas. Nossos resultados sugerem que a corrupção é fenômeno multidimensional com efeitos generalizados e diversos provocando resultados controversos. Uma melhor compreensão da percepção dos efeitos colaterais da corrupção é obtida quando a corrupção é empregada como variável de moderação. Os resultados revelam um efeito negativo potencial na legitimidade democrática. Nosso estudo contribui para a expansão da literatura sobre corrupção versus qualidade e imagem das instituições públicas do país. Concluímos com uma discussão sobre as implicações práticas relacionadas às nossas descobertas.
ACE2 Protein-Protein Interaction Networks Reveal Potential Druggable Targets For SARS-CoV-2
Authors: Xia Qiaoxi , Zhou Xiao , Chen Mantong , Lin Ling , Zhao Yan , Zheng Xiaoqi , Peng Zhongte , Huang Meihui , Wang Shaohong , Du Zepeng
Published: September 2021

Background: The novel coronavirus SARS-CoV-2 pandemic has infected more than 130 million people, killed over 2.3 million so far. Currently, no effective drugs are available to treat this infectious disease, due to limited knowledge of the molecular mechanisms of SARS-CoV-2 infection. ACE2 (angiotensin I converting enzyme 2) has long been identified as the major receptor for coronavirus entry the host cells. Methods: In this study, we constructed the protein-protein interaction networks (PPIN) based on ACE2 and its interacting proteins, considering with the expression alternation and co-expression relationship. The potential drugs targeting the proteins in the PPIN were explored.Results: ACE2 and its interacting proteins AAMP and HRAS are obviously increased, and their PPIN show distinguishing expression patterns during the COVID-19 progression. At least six pathways are activated for the host cell in the response to the virus. Moreover, drug-target networks were built to provide important clues to block ACE2 and its interacting proteins. Except the reported four drugs for ACE2, its interacting protein CALM1 and HRAS are great potentially druggable. We also considered the path initiated from ACE2 to nucleus by cascades of interaction, especially for the transcription factors in the PPIN which are also druggable.Conclusion: In summary, this study provides new insight into the disruption of the biological response to virus mediated by ACE2, but also its cascade interacting proteins when considering of PPIN.
What Does the Chinese General Public Understand About Dementia Prevention?
Authors: Zeng Li , Fan Tianli , Zhou Jie , Chang Jing , Song Dan
Published: September 2021

Background: Although considerable progress has been made on the risk factors of dementia, less is known about the extent of the gaps between the general public’s understanding of dementia prevention and contemporary scientific evidence. This study aimed to determine the beliefs and knowledge of dementia prevention among the Chinese general public and examine the sociodemographic factors of the belief and knowledge of dementia prevention. Methods: The study adopted a cross-sectional design. A total of 358 Chinese adults aged over 40 years were recruited from four healthcare centers. Descriptive statistics and multivariate regression analyses were conducted. We designed questionnaires that include items on the belief of dementia prevention, risk factors for dementia, and health education needs regarding dementia prevention based on previous literature.Results: Only 32.4% of the respondents agreed that dementia is preventable. The correct response rate is low for the items that suggest that cardiovascular risk factors are dementia risk factors. Younger age, higher education, and having contact with patients with dementia are associated with stronger belief that dementia is preventable. Older age, higher income, higher education, having memory complaint, and having contact with patients with dementia are associated with a better understanding of dementia risk factors. A total of 88.9% respondents thought that they are not well informed of dementia from public education, and most respondents (65%) prefer receiving dementia-related health advice from primary care providers.Conclusion: The present study reveals the great gaps between the Chinese general public’s knowledge of dementia prevention and the latest research evidence. Public health educational programs for all age groups are encouraged to close this knowledge gap. More attention and resources should be paid to individuals with low income and low education level as they have limited access to dementia prevention information. Researchers should work in partnership with primary care providers to help translate evidence into community practice with a special focus on the link between cardiovascular risk factors and dementia.
Enhancing digital ink-jet printing patterns quality through controlling the crystallinity of cotton fibers
Authors: Zhao Hongzhi , Wang Dezhen , Fang Kuanjun , Zhang Kun , Pan Ying , Liu Qingbao , Shi Furui , Xie Ruyi , Chen Weichao
Published: September 2021

Cotton fibers have a high crystallinity, which makes a large number of reactive hydroxyl groups blocked and therefore affects the ink-jet printing performance of reactive dyes on cotton fabrics. In this work, the alkali treatment was employed to adjust the structure of cotton fibers. The crystallinity of treated cotton fibers reduced from 73.9–58.5%, and the breaking strength did not decrease compared with original cotton fiber. Thus, the accessible reactive hydroxyl groups and the wettability were enhanced for treated cotton fibers, which promoted the penetration of inks into the fibers. The optimal K/S value of 23.47 was achieved for treated cotton fabrics which was higher than that of untreated cotton fabrics (17.15). Meanwhile, the printed fabrics displayed good washing fastness, rubbing fastness and glossiness. This work provides an effective way for improving the utilization of dye solution and producing high-quality cotton fabric digital printing products.
The tsRNAs (tRFdb-3013a And tRFdb-3013b) Serve As Novel Biomarkers For Colon Adenocarcinomas
Authors: Wu Xiaoling , Tan Lihong , Tang Zhurong , Wen Chunjie , Chen Huan , Cao Weiguo , Zou Hecun
Published: September 2021

Background: The tsRNAs (tRNA-derived small RNAs) are novel class of small non-coding RNAs derived from transfer-RNAs. Colon adenocarcinoma (COAD) are well known malignant intestinal tumors. This study focused on the identification and characterization of tsRNA biomarkers in colon adenocarcinomas. Methods: Data processing, bioinformatic analysis and visualization were performed with R or Python software. The cell proliferation, migration and invasion ability were described by CCK-8 and transwell assays. Luciferase reporter assays were performed to test the binding of tsRNA with its target.Results: With computational approaches, we identified the tsRNA fragments profiles within COAD datasets, and discriminated forty-two differentially expressed tsRNAs between colon adenocarcinomas and non-tumor controls. Among the fragments derived from the 3′ end of mature tRNA-His-GUG (a histidyl-transfer-RNA), tRFdb-3013a and tRFdb-3013b (tRFdb-3013a/b) were significantly decreased in colon adenocarcinomas, especially, tRFdb-3013a/b may tend to down-regulated in the patients with lymphatic or vascular invasion present. The clinical survival of colon adenocarcinomas patients with low tRFdb-3013a/b expression was significantly worse than that of high expression patients. In colon adenocarcinoma cells, tRFdb-3013a could suppressed cell proliferation, and reduced cell migration and invasion ability. The enrichment analyses showed that most of tRFdb-3013a-related genes were enriched in the extracellular matrix associated GO terms, phagosome pathway, and a GSEA molecular signature. Mechanically, the 3′UTR of ST3GAL1 mRNA was predicted to contain the putative binding sites of tRFdb-3013a/b, tRFdb-3013a/b might directly target ST3GAL1 and regulate ST3GAL1 expression in colon adenocarcinomas. Conclusions: These results suggested that tRFdb-3013a and tRFdb-3013b might serve as novel biomarkers for diagnosis and prognosis of colon adenocarcinomas, and play an important role in tumor progression of colon adenocarcinomas.
Shedding Light On An Undiscovered Aspect That Perfectly Mimics Cosmic Acceleration
Authors: Takkhi Karan R.
Published: September 2021

The comparison of redshift-distance relationship for high and low-redshift supernovae revealed the surprising transition of Universe’s expansion from deceleration to acceleration. As compared to local supernovae, remote supernovae are further away than expected. The expansion rate obtained for local supernovae is higher with low redshifts as compared to the expansion rate obtained for remote supernovae with high redshifts. Since observed redshifts provide an estimate of recession/expansion velocities in order to determine the expansion rate (km s-1 Mpc-1) of the Universe, therefore, it is very disturbing to find that low recession velocities (just 1% of speed of light) indicate a faster rate of expansion (acceleration), whereas high recession velocities (60% of speed of light) indicate a slower rate of expansion (deceleration). In this paper I unravel an undiscovered aspect that perfectly mimics cosmic acceleration. Rather than “cosmic deceleration that preceded the current epoch of cosmic acceleration”, I show that “consecutive expansion epochs of the Universe that preceded the current expansion epoch were responsible for placing remote supernovae further away than expected”. As a consequence of consecutive expansion, expansion began for remote structures in preceding expansion epochs before it did for local structures in the current expansion epoch; remote supernovae are therefore not only further away than expected, but they also happen to yield a slower rate of expansion even with “superluminal expansion velocities”. As a result of consecutive expansion, preceding expansion epochs appear to be decelerating as compared to the expansion epoch that succeeds them. The results obtained have been confirmed by plotting velocity-distance relationship, expansion rate vs. time relationship, expansion factor vs. time relationship, scale factor vs. time relationship, scale factor vs. distance relationship, distance-redshift relationship, and distance modulus vs. redshift relationship, moreover, deceleration parameter (q0) is also found to be negative (q0 < 0).