bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Identification of Internalizing Human Single-Chain Antibodies Targeting Brain Tumor Sphere Cells
Authors: Zhu Xiaodong , Bidlingmaier Scott , Hashizume Rintaro , James C. David , Berger Mitchel S. , Liu Bin
Published: April 2023

Abstract
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain tumor for which there is no curative treatment to date. Resistance to conventional therapies and tumor recurrence pose major challenges to treatment and management of this disease, and therefore new therapeutic strategies need to be developed. Previous studies by other investigators have shown that a subpopulation of GBM cells can grow as neurosphere-like cells when cultured in restrictive medium and exhibits enhanced tumor-initiating ability and resistance to therapy. We report here the identification of internalizing human single-chain antibodies (scFv) targeting GBM tumor sphere cells. We selected a large naive phage antibody display library on the glycosylation-dependent CD133 epitope–positive subpopulation of GBM cells grown as tumor spheres and identified internalizing scFvs that target tumor sphere cells broadly, as well as scFvs that target the CD133-positive subpopulation. These scFvs were found to be efficiently internalized by GBM tumor sphere cells. One scFv GC4 inhibited self-renewal of GBM tumor sphere cells in vitro. We have further developed a full-length human IgG1 based on this scFv, and found that it potently inhibits proliferation of GBM tumor sphere cells and GBM cells grown in regular nonselective medium. Taken together, these results show that internalizing human scFvs targeting brain tumor sphere cells can be readily identified from a phage antibody display library, which could be useful for further development of novel therapies that target subpopulations of GBM cells to combat recurrence and resistance to treatment. Mol Cancer Ther; 9(7); 2131–41. ©2010 AACR.
The Preclinical Pharmacology of Tepotinib—A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations
Authors: Albers Joachim , Friese-Hamim Manja , Clark Anderson , Schadt Oliver , Walter-Bausch Gina , Stroh Christopher , Johne Andreas , Karachaliou Niki , Blaukat Andree
Published: April 2023

The mesenchymal–epithelial transition factor (MET) proto-oncogene encodes the MET receptor tyrosine kinase. MET aberrations drive tumorigenesis in several cancer types through a variety of molecular mechanisms, including MET mutations, gene amplification, rearrangement, and overexpression. Therefore, MET is a therapeutic target and the selective type Ib MET inhibitor, tepotinib, was designed to potently inhibit MET kinase activity. In vitro, tepotinib inhibits MET in a concentration-dependent manner irrespective of the mode of MET activation, and in vivo, tepotinib exhibits marked, dose-dependent antitumor activity in MET-dependent tumor models of various cancer indications. Tepotinib penetrates the blood–brain barrier and demonstrates strong antitumor activity in subcutaneous and orthotopic brain metastasis models, in-line with clinical activity observed in patients. MET amplification is an established mechanism of resistance to EGFR tyrosine kinase inhibitors (TKI), and preclinical studies show that tepotinib in combination with EGFR TKIs can overcome this resistance. Tepotinib is currently approved for the treatment of adult patients with advanced or metastatic non–small cell lung cancer harboring MET exon 14 skipping alterations. This review focuses on the pharmacology of tepotinib in preclinical cancer models harboring MET alterations and demonstrates that strong adherence to the principles of the Pharmacological Audit Trail may result in a successful discovery and development of a precision medicine.
Tratamento cirúrgico da doença de Parkinson
Authors: Teixeira Manoel Jacobsen , Fonoff Erich Talammoni
Published: March 2023

Neste capítulo são abordados o histórico do tratamento cirúrgico da doença de Parkinson, as principais indicações e contra-indicações dos diversos tipos de procedimentos,considerando as cirurgias clássicas de neuroablação (palidotomias e talamotomias), modernas técnicas de neuroestimulação cerebral profunda e, mais recentemente, perspectivas de abordagens relacionadas a transplantes neurais, particularmente protocolos atuais de transplante de células tronco.
A practical study of the main transformations from social welfare to social development in Lesotho: Success factors, challenges and prospects
Authors: Manyeli Tšepang
Published: April 2023

Lesotho recently experienced a paradigm shift from social welfare to social development. The study was aimed at assessing achievements and challenges that resulted from the transition. A sequential mixed-methods approach was used. In the quantitative strand, a sample of 150 social workers and 300 beneficiaries was randomly selected, out of which a sample of four social workers’ focus groups were purposively formed. Data were collected through questionnaires, structured interviews and focus group discussions. The community development programme serves as a means to incorporate a social development approach. The article recommends integration of the social development approach in specialised programmes.
Seize the Time! How Perceived Busyness Influences Tourists’ Preferences for Destination Advertising Messages
Authors: Yang Chen , Hu Jing
Published: April 2023

This study examines the impact of perceived busyness on the effectiveness of destination advertising based on construal level theory. Results from four experiments using two different tourism destination settings (i.e., water sports park and spa resort) indicate that low- (vs. high-) construal tourism destination advertisement is more effective for tourists with higher (vs. lower) busyness perception. This relationship is mediated by the need for time efficiency and benefit focus (serial mediation) and is strengthened when the achievement motivates (i.e., hope of success and fear of failure) of the tourist are high. Our study enriches tourism research by revealing that the effectiveness of destination advertising depends on a matching effect between advertising messages and tourists’ perceived busyness. It also has practical ramifications for destination marketing organizations in that it can enhance their understanding of tourists’ decision-making process with perceived busyness as an internal factor and thus help promote their destinations.
Diffusion and Future Influence of Tourism Research: Addressing the How and When Questions of Tourism Knowledge Structures
Authors: Kouropalatis Yiannis , Zenker Sebastian , Morgan Robert E. , Lindgreen Adam
Published: April 2023

This article addresses how core tourism research has influenced other cognate research disciplines through the diffusion of its knowledge structure and when, in the future, this diffused knowledge structure might evolve in terms of research expansion and contraction. Study 1 analyses 4,753 tourism research articles, revealing seven core clusters that represent the tourism discipline. The study then determines how this core influences other cognate research disciplines by identifying 14 clusters from 38,657 articles representing the diffused knowledge structure of tourism research. Diffusion is assessed within and among core and diffused knowledge structures. Study 2 forecasts when and to what extent citation patterns—in the form of research expansion and contraction—are likely to change.
A Rare Combination of Acquired Lymphangioma of the External Auditory Canal and Cholesteatoma in the Middle Ear Cavity
Authors: Chen Yung-Hsuan , Huang Shun-Chen , Hwang Chung-Feng
Published: April 2023

Lymphangioma (LM) is a rare but benign tumor derived from lymphatic malformation, which is extremely rare in the auditory canal or middle ear cavity. We presented a case of acquired lymphangioma of the external auditory canal combined with cholesteatoma in the middle ear cavity. To our best knowledge, this is the first case of combined lesions of lymphangioma and cholesteatoma in English literature.
The effect of an integrated palliative care intervention on quality of life and acute healthcare use in patients with COPD: Results of the COMPASSION cluster randomized controlled trial
Authors: Broese Johanna , van der Kleij Rianne MJJ , Verschuur Els ML , Kerstjens Huib AM , Bronkhorst Ewald M , Engels Yvonne , Chavannes Niels H
Published: April 2023

Background:

COPD causes high morbidity and mortality, emphasizing the need for palliative care.

Aim:

To assess the effectiveness of palliative care in patients with COPD.

Design:

Cluster randomized controlled trial (COMPASSION study; Netherlands Trial Register (NTR): NL7644, 07-04-2019). Healthcare providers within the intervention group were trained to implement palliative care components into routine COPD care. Patients completed questionnaires at baseline, after 3 and 6 months; medical records were assessed after 12 months. The primary outcome was quality of life (FACIT-Pal). Secondary outcomes were anxiety, depression, spiritual well-being, satisfaction with care, acute healthcare use, documentation of life-sustaining treatment preferences and place of death. Generalized linear mixed modelling was used for analyses.

Setting:

Eight hospital regions in the Netherlands.

Participants:

Patients hospitalized for an acute exacerbation of COPD and positive ProPal-COPD score.

Results:

Of 222 patients included, 106 responded to the questionnaire at 6 months. Thirty-six of 98 intervention patients (36.7%) received the intervention. Intention-to-treat-analysis showed no effect on the primary outcome (adjusted difference: 1.09; 95% confidence interval: −5.44 to 7.60). In the intervention group, fewer intensive care admissions for COPD took place (adjusted odds ratio: 0.21; 95% confidence interval: 0.03–0.81) and strong indications were found for fewer hospitalizations (adjusted incidence rate ratio: 0.69; 95% confidence interval: 0.46–1.03).

Conclusions:

We found no evidence that palliative care improves quality of life in patients with COPD. However, it can potentially reduce acute healthcare use. The consequences of the COVID-19 pandemic led to suboptimal implementation and insufficient power, and may have affected some of our findings.
Driver Understanding and Secondary Task Performance While Viewing Traffic Safety Messages on Dynamic Message Signs
Authors: Ullman Gerald L. , Higgins Laura L. , Chrysler Susan T. , Geiselbrecht Tina S. , Simek Chris L. , Stoeltje Gretchen , Wolfe Dave , Benson Gabby
Published: April 2023

Many agencies use dynamic message signs to display behavioral traffic safety (BTS) messages (e.g., CLICK IT OR TICKET, DONT DRINK AND DRIVE). However, little guidance exists on how best to design and display such messages on those signs. In this paper, the results of a human factors laptop-based study are described, which examined how well drivers can read and interpret BTS messages while simultaneously attending to a secondary control task similar to how drivers must operate their vehicle while simultaneously reading road signs. The study results indicated that displaying BTS messages that include humor, wit, or pop culture references could have adverse consequences on driving behavior for motorists who are unable to correctly interpret the safety topic of those messages. The results also indicated that BTS messages should only address a single safety topic. The length of the BTS message should be kept to 16 words or fewer in low to moderate driver workload environments; in high driver workload environments, BTS messages should be limited to 11 words or fewer.
Pelvic Floor Muscle Training for Urinary Incontinence After Radical Prostatectomy: A Narrative Review
Authors: Giraudo Donatella , Lamberti Gianfranco , Ciardi Gianluca
Published: April 2023

Rehabilitative treatment of urinary incontinence after prostatectomy has showed, on the basis of recent published evidence, encouraging results. At first, clinician applied evaluation and treatment approach suggested based on the studies and rationale of female stress urinary incontinence, but although long term literature suggested no evidence of benefits. Recent studies that have shown the real control mechanisms in male continence through the use of trans-perineal ultrasound, demonstrated that it is not appropriate to transfer the rehabilitation techniques applied in female stress incontinence to male incontinence after prostatectomy. Even that pathophysiology of urinary incontinence after prostatectomy is not fully understood, it’s in part attributable to a urethral or bladder source. In particular, however, urethral sphincter dysfunction is predominant, secondary to surgical damage and to the partly organic and partly functional dysfunction of the external urethral sphincter; complementary action of all the muscles capable of contributing to the maintenance of urethral resistance is therefore important. As for rehabilitative approach to post-prostatectomy incontinence, the primary objective is to quantify the residual capacity of the muscular function that must replace the sphincter function, often compromised by surgery. Than a multimodal approach, comprising exercise and instrumental therapies, is needed. The present paper’s aim was to overview current urinary dysfunction knowledge for male with radical prostatectomy, and to describe practical issue of evaluation and conservative treatment.
Black Political Economy, Solidarity Economics, and Liberation: Toward an Economy of Caring and Abundance
Authors: Gordon-Nembhard Jessica
Published: April 2023

Combining Black political economy and solidarity economy theories and practices provides alternative models for group development based on recognizing and developing internal (to the individual and to the community) capacities and creating mechanisms that equitably produce, distribute, recycle, and multiply local expertise and capital within communities of color, especially Black, communities—creating a solidarity economy of caring community for survival (successful social reproduction), sustainability, and liberation. The history of mutual aid, cooperative ownership, and economic democracy among African Americans demonstrates how economic cooperation and solidarity economics have enabled Blacks to address human needs, generate income, and at the same time be family and community friendly, in reaction to anti-Blackness and racial economic inequality. Cooperatives enable low-income residents, women, immigrants, and people of color (who often are without any avenue to gain income or assets) to provide affordable, quality goods and services in ecologically sustainable ways and generate jobs, stabilize their communities, and accumulate some assets. The history of African American cooperative ownership demonstrates that Black Americans have been successful in creating and maintaining collective and cooperatively owned enterprises that often provided not only economic stability for members and their communities but also developed many types of human and social capital and developed community-wide well-being. I discuss how this helps us to define an economics of abundance and explore possibilities for achieving economic liberation in the twenty-first century.

JEL Classification: J15, B54, P13
Study of the lateral resistance characteristics of ballast bed considering the sleeper group effect
Authors: Jing Pu , Xiao Jie-Ling , Xu Yi , Zhuang Li-Yuan , Yu Si-Xin , Wang Ping , Liu Hao , Qi Tian-You
Published: April 2023

By establishing the ballast track full scale model, this paper tested and compared the difference between the resistance of the sleeper group and the resistance of a single sleeper, and studied the effect of sleeper group on lateral resistance. The model of the ballast bed was established based on the discrete element method. We compared the lateral resistance of ballast bed composed of different number of sleepers and analyzed the particle movement and the contact characteristic. According to case calculations, we analyzed the lateral stability of continuous welded rail (CWR) considering the effect of sleeper group. The results show that the average resistance of five sleepers decreased by about 28% compared with that of a single sleeper. With the increase of sleeper’s number, the average resistance gradually becomes stable. The reduction of lateral resistance under the effect of sleeper group mainly occurs in the ballast side and sleeper end area and there is a common area of resistance at the side and end of sleepers. When the sleeper displacement reaches 2 mm, the contribution rate of crib resistance in the independent area and the common area is about 4.3:1:1, and the contribution rate of shoulder resistance is about 3.2:1:1. To ensure the safety of the CWR operation, it is suggested that at least three sleepers should be pushed at the same time when testing the lateral resistance and use the average lateral resistance as a reference value.
Event-triggered dynamic output feedback control of switched cyber-physical systems with stochastic cyber attacks
Authors: Luo Wende , Hou Linlin , Shi Kaibo
Published: April 2023

This article is concerned with the problem of event-triggered dynamic output feedback control for switched cyber-physical systems subject to stochastic cyber attacks. Two kinds of stochastic cyber attacks obeyed the Bernoulli distribution are taken into account, and a switched stochastic system is derived. An event-triggered strategy is adopted to reduce unnecessary communication and save system resources, and then an event-triggered–based dynamic output feedback controller is designed. The sufficient conditions for the mean-square exponential stability of the switched stochastic system are given by taking advantage of the mode-dependent average dwell time method and the multiple Lyapunov functional technique. Finally, the validity of the proposed theoretical results is verified by two examples.
Development and Optimization of Phytosome for Enhancement of Therapeutic Potential of Epiyangambin in Tinospora cordifolia Extract Identified by GC–MS and Docking Analysis
Authors: Kumar Deivasigamani Senthil , Deivasigamani Karthikeyan , Roy Biswabara
Published: April 2023

Background

To enhance the therapeutic potential of Tinospora cordifolia phytosomes, a chloroform extract was prepared.

Objectives

The goal of this study was to create and test the therapeutic potential of a phytosome containing T. cordifolia extract.

Materials and Methods

The extraction of nonpolar compounds was carried out using chloroform as solvent. The active constituent of the extract was subjected to phytochemical and Gas Chromatography–Mass Spectrometry (GC–MS) analyses. Docking studies against multiple targeted proteins confirmed the anti-diabetic, anti-inflammatory, and analgesic properties of T. cordifolia extract. The phytosomes of T. cordifolia extract were prepared by solvent evaporation technique. The phytosomes were characterized for vesicle size, entrapment efficiency, surface morphology, FTIR, in vitro drug release and in vivo anti-diabetic, anti-inflammatory, and analgesic activities.

Results

The highest concentration was found to be 16.58% for epiyangambin. The reported compound inhibits GLUT1 and COX2 with 9.25 and 8.34 kcal/mol binding scores. The optimized TCP4 exhibited 454.2 ± 8.1 nm of vesicle size, –43.1 ± 7.5 mV of zeta potential, and 0.33 of polydispersity index (PDI). The phytosomes exhibited a spherical shape confirmed by TEM analysis. The formulation TCP4 showed a significantly higher release (94.7% ± 1.7%) than pure extract. TCP4 exhibited potent therapeutic potential for anti-diabetic, anti-inflammatory, and analgesic activity.

Conclusion

Chloroform extract loaded phytosomes with cholesterol as lipids exhibited significant therapeutic potential due to the presence of epiyangambin.
Effects of Tetrandrine on the Apoptosis of Cisplatin-resistant Oral Cancer Cells
Authors: Chang Chin-Wen , Chen Chun , Chang Chih-Wei , Chiu Po-Yen , Yang Jai-Sing , Chen Fu-An
Published: April 2023

Background

Cisplatin, the first-line drug for chemotherapy, often has limited treatment efficacy because of resistance and cancer recurrence mechanisms. Tetrandrine is a unique secondary metabolite of Stephania tetrandra. As a traditional Chinese medicine agent, tetrandrine has been reported to have antioxidant, anti-inflammatory, antitumor, and antiangiogenesis activities and has been shown to inhibit the proliferation and angiogenesis of colorectal, lung, and breast cancer cells; potential mechanisms underlying its activities include the promotion of tumor cell apoptosis, promotion of cell cycle arrest, and intensification of reactive oxygen species (ROS) production.

Objectives

The main treatments for oral cancer are chemotherapy, surgery, and radiotherapy; these treatments are often used in combination. Cancer cells easily develop cisplatin resistance; therefore, we investigated tetrandrine’s potential as a therapy for overcoming resistance to oral cancer drugs.

Materials and Methods

We used the cisplatin-resistant oral cancer CAR cell line (CAL27) as a research objected and applied inhibitor treatment to clarify the role of tetrandrine in cell death and mitochondrial dysfunction.

Results

Tetrandrine could effectively inhibit CAR cell proliferation and induce apoptosis, with a corresponding increase in ROS production in mitochondria. Moreover, tetrandrine increased caspase-9 and caspase-3 activity in CAR cells and induced apoptotic mRNA, caspase-3/-9, AIF, and Endo G overexpression. Our results indicate that tetrandrine induces apoptosis in CAR cells through a mitochondrial-dependent signaling pathway.
Building a new regional home for implementation science: Annual Midwest Clinical & Translational Research Meetings
Authors: Scanzera Angelica C , Nyenhuis Sharmilee M , Rudd Brittany N , Ramaswamy Megha , Mazzucca Stephanie , Castro Mario , Kennedy David J , Mermelstein Robin J , Chambers David A , Dudek Steven M , Krishnan Jerry A
Published: April 2023

The vision of the Central Society for Clinical and Translational Research (CSCTR) is to “promote a vibrant, supportive community of multidisciplinary, clinical, and translational medical research to benefit humanity.” Together with the Midwestern Section of the American Federation for Medical Research, CSCTR hosts an Annual Midwest Clinical & Translational Research Meeting, a regional multispecialty meeting that provides the opportunity for trainees and early-stage investigators to present their research to leaders in their fields. There is an increasing national and global interest in implementation science (IS), the systematic study of activities (or strategies) to facilitate the successful uptake of evidence-based health interventions in clinical and community settings. Given the growing importance of this field and its relevance to the goals of the CSCTR, in 2022, the Midwest Clinical & Translational Research Meeting incorporated new initiatives and sessions in IS. In this report, we describe the role of IS in the translational research spectrum, provide a summary of sessions from the 2022 Midwest Clinical & Translational Research Meeting, and highlight initiatives to complement national efforts to build capacity for IS through the annual meetings.
The use of electroencephalogram to characterize subjective evaluation with illuminance as the independent variable
Authors: Hu Songtao , Ma Haonan , Lu Mingli , Wang Fulai
Published: April 2023

The purpose of this study is to explore a new method for characterizing the subjective evaluation under different illuminance level by using electroencephalogram (EEG). The EEG signals and the subjective evaluation (i.e. visual comfort, spaciousness, brightness and visual appearance) from 16 subjects under 6 illuminance levels (75, 100, 200, 300, 500 and 850 lx) were collected. The results showed a significant correlation between subjective evaluation and illuminance. In addition, the logarithmic power of β band was significantly positively correlated with the illuminance ( p < 0.05), and the relationship between the comprehensive subjective satisfaction and the logarithmic power of β band was obtained. Based on this study, the method characterizing subjective evaluation based on the logarithmic power of β band was proposed. Therefore, this research provides a reference method for indoor light environment design based on the physical and mental health of residents.
Digital treatment planning and clear aligner therapy: A retrospective cohort study
Authors: Meade Maurice J , Ng Elizabeth , Weir Tony
Published: April 2023

Objective:

To investigate the total number of digital treatment plan (DTPs) and aligners manufactured for clear aligner therapy (CAT) by Invisalign® from initial treatment planning to the completion of CAT.

Design:

A retrospective cohort study.

Material and methods:

A total of 30 patients, from each of 11 experienced orthodontists, who commenced treatment over a 12-month period, were assessed regarding the number of DTPs and aligners prescribed from initial planning to completion of CAT. Patients were categorised according to the number of aligners prescribed by the initial DTP into mild (<15), moderate (15–29) or severe (>29).

Results:

After the application of inclusion/exclusion criteria, 324 patients (71.9% women; median age = 28.5 years) undergoing non-extraction treatment with the Invisalign® appliance were assessed. The median number of initial DTPs was 3 (interquartile range [IQR] = 2, 1–9) per patient before acceptance by the orthodontist. Most (99.4%) patients required a refinement phase with a median of 2 (IQR = 2, 2–7) refinement plans recorded. A total of 9135 aligners per dental arch, was prescribed in the initial DTP of the 324 patients assessed and 8452 in the refinement phase. The median number of aligners per dental arch prescribed from the initial DTP was 26 (IQR = 12, 6–78) and from the refinement plans was 20.5 (IQR = 17, 0–132).

Conclusion:

A median of three initial DTPs and two refinement plans were required for patients undergoing non-extraction treatment with the Invisalign® appliance. Patients were prescribed almost double the number of aligners initially predicted to manage their malocclusion.
A phase Ia dose-escalation trial of Ametumumab (a fully human monoclonal antibody against epidermal growth factor receptor) in patients with advanced solid malignancies
Authors: Li Da , Pan Hong , Wang Wei , Xue Yanan , Fang Yong , Lou Haizhou , Pan Qin , Jin Wei , Zheng Yu , Han Weidong , Zhu Kongli , Zhao Xianfeng , Xu Rong , Han Jin , Pan Hongming
Published: April 2023

Background:

Epidermal growth factor receptor (EGFR) is a well-known target for cancer treatment. However, the authorized anti-EGFR monoclonal antibodies generally cause several toxic effects, especially severe cutaneous toxicities as well as infusion reactions, and the clinical indications are limited. Here we developed Ametumumab, a fully human recombinant anti-EGFR monoclonal antibody.

Objectives:

To assess the safety, tolerability, pharmacokinetics (PK), and immunogenicity of Ametumumab.

Design:

A first-in-human phase Ia dose escalation study of Ametumumab in patients with advanced solid malignancies.

Methods:

An open-label, first-in-human dose escalation study was done in 22 patients with advanced malignancies who received six ascending dosages ranging from 75 to 750 mg/m2. Following a single dosage and a 28-day dose-limiting toxicity (DLT) monitoring period, patients were given repeated doses weekly. Blood samples were taken to determine the PK parameters of Ametumumab and anti-drug antibody concentrations. Every 8 weeks, radiographic tumor evaluations were conducted.

Results:

In this trial, no DLT was observed, and the maximum tolerated dose was not reached at doses up to 750 mg/m2. There were no severe adverse events but mild and moderate adverse effects, such as headache, proteinuria, and rash. Single-dose PK results demonstrated a straightforward linear relationship with dosage escalation. The medication concentrations accumulated and attained steady-state after four rounds of injections. It was calculated that 10 patients with disease control would be observed in the 22 evaluable patients. The disease control rate was 45.5%.

Conclusion:

The Ametumumab was well tolerated and safe in patients with advanced solid malignancies, exhibiting minimal immunogenicity, a long half-life, high levels of drug exposure in the blood, and preliminary effectiveness.

Registration:

The trial was registered with CTR20170343 on 10 April 2017, The China Center for Drug Evaluation.
Surgical Construct Type Is Associated With Time to Fusion and Reoperation Rate in Double and Isolated Talonavicular Arthrodeses
Authors: Guareschi Alexander S. , Hoch Caroline , Reid Jared J. , Scott Daniel J. , Gross Christopher E.
Published: April 2023

Background

This study evaluates the effect of surgical construct on postoperative outcomes in patients undergoing isolated talonavicular (TN) or double (TN and subtalar ST) arthrodesis. TN constructs included plate and screw, screw and staple, and isolated staple constructs. Subtalar constructs included 1- and 2-screw constructs.

Methods

Retrospective chart review identified 52 patients who underwent double or isolated TN arthrodesis between 2016 and 2021 by a single fellowship-trained foot and ankle surgeon with minimum 6 months of follow-up (mean = 1.62 years, range = 0.50-4.39 years). Data collected included demographics, medical history, surgical indication, surgical constructs used, complications, reoperations, patient-reported outcome measures, and radiographic measures.

Results

Overall complication and reoperation rates were 26.3% and 12.3%, respectively. Among TN constructs, time to ST (P = .026) and TN (P = .018) fusion was significantly slower among patients receiving a plate and screw construct. Complication rate did not differ, but reoperation rate was significantly higher for plate and screw TN constructs (P = .039). Postoperative Foot and Ankle Outcome Score (FAOS) Quality of Life (P = .028) and Total (P = .016) scores were significantly better among plate and screw TN constructs.

Conclusion

Utilization of screw and staple or isolated staple construct have significantly quicker time to fusion and lower reoperation rates than plate and screw constructs for the TN joint.

Level of Evidence:

Level III: Retrospective cohort study
Post-ictal changes presenting as late pseudoprogression on MRI and PET in a patient with diffuse glioma: Case report and brief literature review
Authors: Nair Swetha M , Sahu Arpita , Dasgupta Archya , Puranik Ameya , Gupta Tejpal
Published: April 2023

Following completion of adjuvant radiation and chemotherapy imaging surveillance forms a major role in the management of diffuse gliomas. The primary role of imaging is to detect recurrences earlier than clinical symptomatology. Magnetic resonance imaging (MRI) is considered the gold standard in follow-up protocols owing to better soft tissue delineation and multiparametric nature. True recurrence can often mimic treatment-related changes, it is of paramount importance to differentiate between the two entities as the clinical course is divergent. Addition of functional sequences like perfusion, spectroscopy and metabolic imaging can provide further details into the microenvironment. In equivocal cases, a follow-up short interval imaging might be obtained to settle the diagnostic dilemma. Here, we present a patient with diagnosis of recurrent oligodendroglioma treated with adjuvant chemoradiation, presenting with seizures five years post-completion of chemotherapy for recurrence. On MRI, subtle new onset gyral thickening of the left frontal region with mild increase in perfusion and patchy areas of raised choline. FET-PET (fluoro-ethyltyrosine) showed an increased tumour-to-white matter (T/Wm) ratio favouring tumour recurrence. Based on discussion in a multi-disciplinary joint clinic, short interval follow-up MRI was undertaken at two months showing decrease in gyral thickening and resolution of enhancing areas in left frontal lobe. Repeat imaging one year later demonstrated stable disease status without further new imaging findings. Given the changes resolving completely without any anti-tumoral intervention, we conclude this to be peri-ictal pseudoprogression, being the second such case described in India.
On the Restorative Break: Understanding the Role of Break Room Design on Nurse Engagement and Satisfaction
Authors: Lorusso Lesa , Ossmann Michelle , Orozco Tatiana , Lawson Linda
Published: April 2023

Background:

Healthcare organizations need to attract and retain qualified nurses, and break areas may influence nurse engagement with breaks, but this has not been studied in situ. The goal of this study was to understand nurse perception of breaks and ways building design and culture impact the frequency, duration, and location of nurse breaks.

Methods:

This was Part 1 of a two-part study. Mixed-method approaches included on-site behavior mapping, focus groups, online survey, and break room usage rates analysis.

Findings:

In this study, nurses did not take restorative breaks but focused on quick “bio” breaks in rooms nearest the central nurse station. When nurses left care floors, they preferred the cafeteria and outdoor eating spaces.

Conclusion:

Nurses’ proclivity to minimize restorative breaks remains a major organizational concern. Future studies should investigate leadership activities impacting nurses’ perception of shifts and break-taking behavior.

Application to Practice:

By optimizing the break setting and changing the cultural perspective of breaks, occupational health services and healthcare management can support nurses’ engagement in restorative activities.
Evaluating Barriers to CSR in Indian Service Organizations: A Fuzzy Dematel Based Approach
Authors: Ganguly Anirban , Kumar Chitresh , Wood Lincoln C.
Published: April 2023

Section 135 of the Indian Companies Act of 2014 legally mandated large corporates to implement and report on social development work as corporate social responsibility (CSR). The regulatory changes made CSR an integral part of Indian organizations’ business plans and an important metric to assess an organization’s goodwill. However, several barriers have been observed to act as a roadblock to successfully implementing CSR in Indian service organizations. The current study identified and prioritized a set of significant barriers to the implementation of CSR. The study used the MCDM of Fuzzy DEMATEL to prioritize the identified barriers. The findings of the study suggest that ‘lack of financial resources’, ‘support from the top management’ and ‘lack of skills and knowledge’ were the most significant barriers for the Indian services organizations. The study is expected to contribute to the literature on CSR by providing a list of barriers to implementation and their relative influence when regulatory compulsion leads to CSR. For CSR managers, it aids in the decision-making process by understanding and addressing the barriers, easing the process of successfully implementing CSR in Indian service organizations.
Potential to enhance telephone cardiopulmonary resuscitation with improved instructions - findings from a simulation-based manikin study with lay rescuers
Authors: Hölzing Carlos Ramon , Brinkrolf Peter , Metelmann Camilla , Metelmann Bibiana , Hahnenkamp Klaus , Baumgarten Mina
Published: April 2023

Background

Telephone-Cardiopulmonary Resuscitation (T-CPR) significantly increases rate of bystander resuscitation and improves patient outcomes after out-of-hospital cardiac arrest (OHCA). Nevertheless, securing correct execution of instructions remains a difficulty. ERC Guidelines 2021 recommend standardised instructions with continuous evaluation. Yet, there are no explicit recommendations on a standardised wording of T-CPR in the German language. We investigated, whether a modified wording regarding check for breathing in a German T-CPR protocol improved performance of T-CPR.

Methods

A simulation study with 48 OHCA scenarios was conducted. In a non-randomised trial study lay rescuers were instructed using the real-life-CPR protocol of the regional dispatch centre and as the intervention a modified T-CPR protocol, including specific check for breathing (head tilt-chin lift instructions). Resuscitation parameters were assessed with a manikin and video recordings.

Results

Check for breathing was performed by 64.3% (n = 14) of the lay rescuers with original wording and by 92.6% (n = 27) in the group with modified wording (p = 0.035). In the original wording group the head tilt-chin manoeuvre was executed by 0.0% of the lay rescuers compared to 70.3% in the group with modified wording (p < 0.001). The average duration of check for breathing was 1 ± 1 s in the original wording group and 4 ± 2 s in the group with modified wording (p < 0.001). Other instructions (e.g. check for consciousness and removal of clothing) were well performed and did not differ significantly between groups. Quality of chest compression did not differ significantly between groups, with the exception of mean chest compression depth, which was slightly deeper in the modified wording group.

Conclusion

Correct check for breathing seems to be a problem for lay rescuers, which can be decreased by describing the assessment in more detail. Hence, T-CPR protocols should provide standardised explicit instructions on how to perform airway assessment. Each protocol should be evaluated for practicability.
Design of a nanobiosystem with remote photothermal gene silencing in Chlamydomonas reinhardtii to increase lipid accumulation and production
Authors: Alishah Aratboni Hossein , Rafiei Nahid , Uscanga-Palomeque Ashanti Concepción , Luna Cruz Itza Eloisa , Parra-Saldivar Roberto , Morones-Ramirez Jose Ruben
Published: March 2023

Research development in the precise control of gene expression in plant cells is an emerging necessity that would lead to the elucidation of gene function in these biological systems. Conventional gene-interfering techniques, such as micro-RNA and short interfering RNA, have limitations in their ability to downregulate gene expression in plants within short time periods. However, nanotechnology provides a promising new avenue with new tools to overcome these challenges. Here, we show that functionalized gold nanoparticles, decorated with sense and antisense oligonucleotides (FANSAO), can serve as a remote-control optical switch for gene interference in photosynthetic plant cells. We demonstrate the potential of employing LEDs as optimal light sources to photothermally dehybridize the oligonucleotides on the surface of metallic nanostructures, consequently inducing regulation of gene expression in plant cells. We show the efficiency of metallic nanoparticles in absorbing light from an LED source and converting it to thermal energy, resulting in a local temperature increase on the surface of the gold nanoparticles. The antisense oligonucleotides are then released due to the opto-thermal heating of the nanobiosystem composed of the metallic nanoparticles and the sense-antisense oligonucleotides. By applying this approach, we silenced the Carnitine Acyl Carnitine Translocase genes at 90.7%, resulting in the accumulation of lipid bodies in microalgae cells. These results exhibit the feasibility of using functionalized gold nanoparticles with sense and antisense oligonucleotides to enhance nucleic acid delivery efficiency and, most importantly, allow for temporal control of gene silencing in plant cells. These nanobiosystems have broad applications in the development and biosynthesis of biofuels, pharmaceuticals, and specialized chemicals.
A lipid metabolism–based prognostic risk model for HBV–related hepatocellular carcinoma
Authors: Zhou Lili , Xia Shaohuai , Liu Yaoyao , Ji Qiang , Li Lifeng , Gao Xuan , Guo Xiaodi , Yi Xin , Chen Feng
Published: April 2023

Background

Up to 85% of hepatocellular carcinoma (HCC) cases in China can be attributed to infection of hepatitis B virus (HBV). Lipid metabolism performs important function in hepatocarcinogenesis of HBV–related liver carcinoma. However, limited studies have explored the prognostic role of lipid metabolism in HBV–related HCC. This study established a prognostic model to stratify HBV–related HCC based on lipid metabolisms.

Methods

Based on The Cancer Genome Atlas HBV–related HCC samples, this study selected prognosis-related lipid metabolism genes and established a prognosis risk model by performing uni- and multi-variate Cox regression methods. The final markers used to establish the model were selected through the least absolute shrinkage and selection operator method. Analysis of functional enrichment, immune landscape, and genomic alteration was utilized to investigate the inner molecular mechanism involved in prognosis.

Results

The risk model independently stratified HBV-infected patients with liver cancer into two risk groups. The low–risk groups harbored longer survival times (with P < 0.05, log–rank test). TP53, LRP1B, TTN, and DNAH8 mutations and high genomic instability occurred in high–risk groups. Low–risk groups harbored higher CD8 T cell infiltration and BTLA expression. Lipid–metabolism (including “Fatty acid metabolism”) and immune pathways were significantly enriched (P < 0.05) in the low–risk groups.

Conclusions

This study established a robust model to stratify HBV–related HCC effectively. Analysis results decode in part the heterogeneity of HBV–related liver cancer and highlight perturbation of lipid metabolism in HBV–related HCC. This study’s findings could facilitate patients’ clinical classification and give hints for treatment selection.
Existence theory for multiple solutions to second-order singular Dirichlet boundary value problem modeling the Antarctic Circumpolar Current
Authors: Jiang Yongxin , Shi Wei , Li Xiaojuan
Published: March 2023

In the article, we present multiple solutions for a second-order singular Dirichlet boundary value problem that arises when modeling the ocean flow of the Antarctic Circumpolar Current. The main tools of the proof are the Leray–Schauder nonlinear alternative principle and a well-known fixed point theorem in cones.
Carbon emission trading system and stock price crash risk of heavily polluting listed companies in China: based on analyst coverage mechanism
Authors: Xie Zeyu , Yang Mian , Xu Fei
Published: April 2023

This study reveals the inconsistencies between the negative externalities of carbon emissions and the recognition condition of accounting statements. Hence, the study identifies that heavily polluting enterprises in China have severe off-balance sheet carbon reduction risks before implementing the carbon emission trading system (CETS). Through the staggered difference-in-difference (DID) model and the propensity score matching-DID model, the impact of CETS on reducing the risk of stock price crashes is examined using data from China’s A-share heavily polluting listed companies from 2007 to 2019. The results of this study are as follows: (1) CETS can significantly reduce the risk of stock price crashes for heavily polluting companies in the pilot areas. Specifically, CETS reduces the skewness (negative conditional skewness) and down-to-up volatility of the firm-specific weekly returns by 8.7% and 7.6%, respectively. (2) Heterogeneity analysis further shows that the impacts of CETS on the risk of stock price crashes are more significant for heavily polluting enterprises with the bear market condition, short-sighted management, and intensive air pollution. (3) Mechanism tests show that CETS can reduce analysts’ coverage of heavy polluters, reducing the risk of stock price crashes. This study reveals the role of CETS from the stock price crash risk perspective and helps to clarify the relationship between climatic risk and corporate financial risk.
Fordonianka Maria Kostrzewska ps. Wiara, Maks (1901–1951)
Authors: Paczoska-Hauke Alicja
Published: April 2023

Autorka przybliżyła postać Marii Kostrzewskiej, jednej z wielu konspiratorek AK i podziemia antykomunistycznego, które mimo upływu wielu lat nadal nie mają swoich grobów. Kostrzewska urodziła się w 1901 r. w Krakowie, była  absolwentką Akademii Handlowej w Krakowie. W czasie wojny była związana z krakowskim Zgrupowanie Armii Krajowej Żelbet. Po zakończeniu działań  wojennych kontynuowała wraz z synem działalność konspiracyjną w ramach Zrzeszenia Wolność i Niezawisłość. Była członkinią Brygady Wywiadowczej oraz szyfrantką Obszaru Południowego Zrzeszenie WiN. Po aresztowaniu i skazaniu przez Wojskowy Sąd Rejonowy w Warszawie przebywała w więzieniu w Fordonie, gdzie ciężko chorowała. Zmarła 25 marca 1951 r. Jej synowi, Andrzejowi do tej pory nie udało się odnaleźć grobu matki.
Temporal changes in Land Use and Land Cover (LULC) and local climate in the Krueng Peusangan Watershed (KPW) area, Aceh, Indonesia
Authors: Ramli Ichwana , Achmad Ashfa , Anhar Ashabul
Published: April 2023

Watersheds are important sources of various ecosystem services. The Krueng Peusangan Watershed (KPW), one of the watersheds in Aceh Province, is expected to become the "lungs" of the ecology of the north-central part of Aceh. Currently, the KPW is one of the watersheds that suffers from severe or critical damage, especially that caused by changes in forest cover. Spatiotemporal monitoring of changes in landscape patterns (composition and configuration) is needed to inform policy and support planning for sustainable watershed management. This study aims to: 1) determine the pattern of changes in LULC in KPW in two decades (1999–2009 and 2009–2019, and 2) determine the impact of changes in the LULC pattern on the local climate. Landsat Satellite Imagery for three years (1999, 2009, and 2019) is used to classify LULC. Geographic Information System (GIS) technology and remote sensing are used to analyze it. Each satellite image is classified into six categories: built-up area, forest, agriculture, bare land, wetland, and water body. This classification resulted in LULC maps for 1999, 2009, and 2019 with kappa coefficients of 0.84, 0.88, and 0.84. It is found that between 1999–2009 and 2009–2019, there has been a consistent decrease in forest cover area and an increase in built-up area. Local climate change is also occurring in this KPW. Continuous monitoring of LULC changes in KPW is also necessary to keep management planning up to date.
Obchody sześćdziesiątych urodzin Bolesława Bieruta i Mátyása Rákosiego w 1952 r. w prasie polskiej i węgierskiej
Authors: Sylburska Aleksandra
Published: April 2023

Tematem artykułu są obchody sześćdziesiątych urodzin liderów polskiej i węgierskiej partii komunistycznej – Bolesława Bieruta oraz Mátyása Rákosiego. Uroczystości miały miejsce prawie w tym samym czasie (9 III i 18 IV 1952 r.). Do opracowania tego tematu wykorzystano prasę polską i węgierską. Najważniejszym celem kampanii prasowej, która towarzyszyła obchodom, były: budowa kultu jednostki niepopularnych wśród rodaków liderów, zmuszenie Polaków i Węgrów do uczestnictwa we współzawodnictwie pracy oraz poprawa wizerunku Stalina i Związku Radzieckiego.
Application of MCE-AHP technical for modelling paddy zoning: A case study in Vietnam
Authors: Hanh Tong Thi , Pham Mai-Phuong , Nga Nguyen Thi Thu , Ahmed Samreen Riaz , Lahori Altaf Hussain , Borodina Nataliia
Published: April 2023

The main aim of present study was to determine the most suitable land for paddy via AHP - GIS and Remote Sensing. Ba Thuoc district - Thanh Hoa province was selected as the target area to conduct the experimental set-up. As per opinion of scientists and the guidance of World Food Organization (FAO) on agricultural crops, the criteria selected to estimate the ecological adaptation of crops include soil type, soil texture, soil depth, soil pH, N (%), elevation, slope, distance from rivers, yearly precipitation, low-average and high temperature, average sunny hours, saltwater intrusion. The land suitability map was generated by superimposing the component maps considering the weighting of the criteria. The obtained results showed that in the experimental area nearly 8.26% of the land-use region was very appropriate for rice growing, 26.29% was observed medium appropriate, 43.35% was less appropriate and 22.1% was not fit for paddy cultivation. Overall, the data may be of value for country government, policy makers, managers as well as local authorities to induce local farmers for paddy production on most suitable areas