bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of different audiovisual landscapes in bamboo forest space on physical and mental restorative potential of university students: based on eye-tracking experiments
Authors: Zhu Chunyan , Feng Xindi , Luo Jinming , Fu Shanshan , Li Tianhui , Wang Wei , Li Xi
Published: August 2024

With its unique audiovisual environment, bamboo forest spaces serve as natural sanctuaries for urban residents, offering significant restorative effects by reducing physical and mental stress and alleviating fatigue. This promotes the vigorous development of outdoor recreation activities. To further explore the restorative effects of bamboo forest space on people's audiovisual perceptual aspects. In this study, we conducted field research in the Southern Sichuan Bamboo Sea, collecting audiovisual materials from four types of bamboo forest spaces: pathway type, cultural type, ornamental type, and recreational. These spatial photographs were combined with three types of soundscapes (silent, background, and background + wind-blown bamboo sound). Eye tracking experiments were utilized to investigate the physical and mental restorative effects of these different audiovisual features on college students. The results showed that in the visual aspect, the visual restorative properties of recreational-type and ornamental-type bamboo spaces were better than those of pathway type and cultural-type spaces; in the auditory aspect, the sounds of wind-blown bamboo, flowing water, and chirping birds in the bamboo forest significantly enhanced the subjective restorative properties of the bamboo forest space, reducing the number of fixations and the average pupil diameter. In addition, this paper found that the soundscape guided people's visual attention, with the wind-blown bamboo sound increasing focus on natural elements, and the extensibility of the bamboo forest space was positively correlated with the number of fixations, while fascination was negatively correlated with the average saccade amplitude. These findings provide insights for the optimized design of audiovisual restorative environments in bamboo forest space in the future.
Efficacy and safety of a novel TKI (anlotinib) for the treatment of advanced digestive system neoplasms: a systematic review and meta-analysis
Authors: Zhou Changhui , Wang Weihua , Mu Ying , Meng Min
Published: August 2024

Objective

To systematically evaluate the efficacy and safety of anlotinib targeted therapy for the treatment of patients with advanced digestive system neoplasms (DSNs).

Methods

Clinical trials were extracted from PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI) and the Wanfang database up to October 2023. Outcome measures, including therapeutic efficacy, quality of life (QOL) and adverse events, were extracted and evaluated.

Results

Twenty trials, including 1,613 advanced DSNs patients, were included. The results indicated that, compared with conventional treatment alone, the combination of anlotinib targeted therapy with conventional treatment significantly improved the patients’ 6-months overall survival (OS, OR=1.76, CI=1.53 to 2.02, P<0.00001), overall response (ORR, OR=1.76, CI=1.53 to 2.02, P<0.00001) and disease control rate (DCR, OR=1.51, 95% CI=1.25 to 1.84, P<0.0001). Moreover, the group that received the combined therapy had higher rates of hypertension (P<0.00001), proteinuria (P<0.00001), fatigue (P<0.00001), diarrhea (P<0.00001), hypertriglyceridemia (P=0.02), alanine aminotransfease (ALT)increased (P=0.004), aspartate transaminase (AST) increased (P=0.006), anorexia (P<0.00001), weight loss (P=0.002), abdominal pain (P=0.0006), hypothyroidism (P=0.02), prolonged QT interval (P=0.04). Analyses of other adverse events, such as gastrointestinal reaction, leukopenia, and neutropenia, did not reveal significant differences (P>0.05).

Conclusion

The combination of anlotinib targeted therapy and conventional treatment is more effective for DSNs treatment than conventional treatment alone. However, this combined treatment could lead to greater rates of hypertension, albuminuria and hand-foot syndrome. Therefore, the benefits and risks should be considered before treatment.
A nomogram prediction of coronary artery dilation in Kawasaki diseases based on mtDNA copy number
Authors: Peng Mou , Yue Peng , Zhang Yue , Li Hong , Hua Yimin , Li Yifei , Zheng Hong , Liu Fangfei
Published: August 2024

Objective

The level of mitochondrial DNA copy number (mtDNA-CN) in peripheral blood cells had been identified to be involved in several immune and cardiovascular diseases. Thus, the aim of this study is to evaluate the levels of mtDNA-CN in Kawasaki disease (KD) and to construct a nomogram prediction for coronary artery lesions in children with KD.

Methods

One hundred and forty-four children with KD diagnosed from March 2020 to March 2022 were involved in the study. The clinical features and laboratory test parameters of these children were assessed between the KD and normal groups. Univariable and multivariable analyses were performed sequentially to identify the essential risk factors. Subsequently, a nomogram prediction was constructed.

Results

A total of 274 children were included in the analysis. Of these, 144 (52.6%) represented the KD group. Peripheral blood DNA mtDNA qPCR showed that the -log value of mtDNA-CN in the KD group (6.67 ± 0.34) was significantly higher than that in the healthy group (6.40 ± 0.18) (P<0.001). The area under the ROC curve for mtDNA-CN in distinguishing KD was 0.757. MtDNA-CN (OR = 13.203, P = 0.009, 95% CI 1.888–92.305), RBC (OR = 5.135, P = 0.014, 95% CI 1.394–18.919), and PA (OR = 0.959, P = 0.014, 95% CI 0.927–0.991) were identified as independent risk factors for coronary artery dilation in children with KD. Finally, the nomogram predictive was established based on the results of multivariable analysis, demonstrating the satisfied prediction and calibration values.

Conclusion

The results of this study revealed that mtDNA-CN could be used as a biomarker in predicting the development of KD. Furthermore, the higher the mtDNA-CN was significantly associated with coronary artery dilation in KD.
Causal relationships between gut microbiota, immune cell, and Henoch-Schönlein Purpura: a two-step, two-sample Mendelian randomization study
Authors: Liang Tian , Shi Huijun , Cui Han , Cui Yaqi , Zhao Ziwei , Wang Yue , Shi Dandan , Tian Peichao
Published: August 2024

Background

Regulating the immune system is a crucial measure of gut microbiota (GM) that influences the development of diseases. The causal role of GM on Henoch-Schönlein Purpura (HSP) and whether it can be mediated by immune cells is still unknown.

Methods

We performed a two-sample Mendelian randomization study using an inverse variance weighted (IVW) method to examine the causal role of GM on HSP and the mediation effect of immune cells between the association of GM and HSP.

Results

We demonstrated the causal relationships between 14 axas and 6 pathways with HSP. Additionally, we identified 9 immune cell characteristics associated with HSP. Importantly, through mediation MR analysis, we identified several immune cell characteristics that mediate the impact of GM on HSP. For instance, Genus_Blautia affects HSP via Monocyte (HLA DR on CD14+ CD16- monocyte) and Monocyte (HLA DR on monocyte). The proportion of mediation effects further elucidated the complex dynamics between GM exposure, immune markers, and their combined impact on HSP.

Conclusion

The study suggested a causal relationship between GM and HSP, which may be mediated by immune cells.
A CFD-DEM-FEM coupling method for the ice-induced fatigue damage assessment of ships in brash ice channels
Authors: Zhou Chenyan , Chen Ling , Zhang Jianing
Published: August 2024

Polar transport ships frequently traverse in the brash ice channel opened by icebreakers. Although the substantial ice resistance caused by direct collisions with the level ice is avoided, the hull still encounters collisions with the brash ice, leading to periodic damage and exacerbating the fatigue issues of the hull structure. To address the fatigue challenges faced by ships sailing in the brash ice channels, this paper proposes an ice-induced fatigue damage assessment method based on the CFD-DEM-FEM. Referring to the brash ice model test conducted at the Hamburg Ship Model Basin (HSVA), a discrete element ice model and a numerical brash ice tank are established using the CFD-DEM coupling method. The simulated ship-ice interaction is compared with HSVA’s experimental results to validate the reliability of the numerical brash ice tank and ice load. The ice load time history resulting from the ship-brash ice collision is applied to the hull, and the hot spot stress time history under each fatigue sub-condition is calculated using the FEM. The improved rain-flow counting method is employed to determine the stress level of the hot spot stress time history, and the S-N curve method based on the linear cumulative damage criterion is used to calculate the total fatigue damage of hot spots. Finally, the results of the proposed method are compared with those of the LR method. This study can serve as a valuable reference for the ice-induced fatigue assessment of ships navigating in brash ice channels.
Ferroelastic twin walls for neuromorphic device applications
Authors: Lu Guangming , Salje Ekhard K. H.
Published: August 2024

The possibility to use ferroelastic materials as components of neuromorphic devices is discussed. They can be used as local memristors with the advantage that ionic transport is constraint to twin boundaries where ionic diffusion is much faster than in the bulk and does not leak into adjacent domains. It is shown that nano-scale ferroelastic memristors can contain a multitude of domain walls. These domain walls interact by strain fields where the interactions near surfaces are fundamentally different from bulk materials. We show that surface relaxations (∼image forces) are curtailed to short range dipolar interactions which decay as 1/d2 where d is the distance between domain walls. In bigger samples such interactions are long ranging with 1/d. The cross-over regime is typically in the range of some 200–1500 nm using a simple spring interaction model.
Fatal nephrobronchial fistula arising from xanthogranulomatous pyelonephritis: a case report
Authors: Burbano María Alejandra , Nati-Castillo H. A. , Castaño-Giraldo Natalia , López Gildardo , Placencia-André Romina , Salazar-Santoliva Camila , Villavicencio-Gomezjurado Melissa , Izquierdo-Condoy Juan S.
Published: August 2024

Introduction

Nephrobronchial fistula is an exceptionally rare complication of renal infections, including the uncommon xanthogranulomatous pyelonephritis. Existing literature is limited to a few case reports, with antibiotic therapy and nephrectomy being the preferred treatments.

Case

We present the case of a 63-year-old woman with a history of recurrent xanthogranulomatous pyelonephritis in her right kidney, requiring drainage through lumbotomy. She presented with a chronic dry cough and weight loss, without other noticeable symptoms. Imaging suggested a pulmonary abscess and nephrobronchial fistula. Despite antibiotic treatment and surgical intervention, her condition progressed fatally.

Conclusion

Nephrobronchial fistulas are extremely complications of renal infections, often presenting with nonspecific symptoms. This case highlights their significant impact on morbidity and mortality, especially in resource-limited settings, and underscoring the urgent need for prompt diagnosis and treatment.
Increased risk of respiratory events during endobronchial ultrasound examination in patients with reduced forced expiratory volume: a prospective observational study
Authors: Grünewaldt Achim , Rohde Gernot
Published: August 2024

Background

The incidence of adverse events during endobronchial ultrasound is low. Nevertheless, it is unclear, whether patients with impaired pulmonary function have an increased risk of respiratory events during the intervention.

Methods

A monocentric prospective observational study was performed at the Department of Respiratory Medicine, University Hospital Frankfurt/Main, Germany. Adult patients undergoing an endobronchial ultrasound examination with propofol-sedation were included. Pre-interventional screening included pulmonary function testing, laboratory tests and electrocardiogram. The occurrence of hypercapnia >55 mmHg or reduced oxygen saturation <85% was defined as a respiratory event was recorded and compared between patients with normal and impaired pulmonary function tests.

Results

In total, 126 patients were included. Pulmonary function testing revealed a median FEV1 of 2.2 l (range 0.4–6.04l) and a predicted FEV1 of 79.5% (range 20–127.8%) respectively. The median FVC was 3.0 l (range 0.87–7.28l), the median predicted FVC was 82% (range 31.4–128.4%). In 72 examinations (60%) pCO2 levels >55 mmHg were measured. Transient oxygen desaturation <85% occurred in 31 cases (25.8%). The Mann Whitney U-test showed a significantly lower FEV1 (% predicted value) in patients with respiratory events (p = 0.007). ROC analysis identified a predicted FEV1 of 78.5% as the optimal cut-off with a sensitivity of 58% and a specificity of 71%. Using Z-score instead of predicted values, there was no significant association between a lower Z- score of FEV or FVC and hypercapnic or hypoxic events. However, both a lower absolute value of FEV1/FVC and a lower Z-score of the FEV1/FVC index were associated with the occurrence of respiratory events. In binary logistic regression analysis, we could not demonstrate any association with other relevant parameters (age, BMI, sedation dosage, sedation duration, or ASA-score).

Conclusions

An impaired forced expiratory volume is associated with the frequency of respiratory events during endobronchial ultrasound examination under propofol-sedation.
An outbreak of Mycoplasma pneumoniae in children after the COVID-19 pandemic, Shanghai, China, 2023
Authors: Zhu Xunhua , Liu Pengcheng , Yu Hui , Wang Libo , Zhong Huaqing , Xu Menghua , Lu Lijuan , Jia Ran , Su Liyun , Cao Lingfeng , Zhai Xiaowen , Wang Yi , Xu Jin
Published: August 2024

Background

During the coronavirus disease 2019 (COVID-19) pandemic, the infection of Mycoplasma pneumoniae (MP) decreased significantly. At the beginning of the summer of 2023, there was an increasing trend of MP infection in China and the MP pneumonia (MPP) is surging when it comes to the school season and lasts for several months which has attracted widespread attention.

Objective

This study aims to investigate the prevalent characteristics of the MP and the difference between the COVID-19 pandemic and the post in Shanghai, China.

Methods

The demographic information and the results of laboratory pathogen detection from July 2021 to May 2024 were collected and analyzed to find out the prevalent characteristics of MP. Two periods, during the COVID-19 pandemic and the post-pandemic, were divided and compared. The P1 genotyping and macrolide resistance-associated gene of 23 s rRNA were detected using the remaining MP-positive samples.

Results

During the COVID-19 pandemic, the prevalence of the MP has significantly decreased. Female children are more susceptible to MP infection than the male. The school-aged group (>6 years) had the highest infection rate. The rate of MP P1 genotype during post panel is higher than that during COVID-19 pandemic, which is dominant from July 2021 to May 2024, while the macrolide-resistant associated mutations (A2063G) keep high percentage during or post pandemic.

Conclusion

After the COVID-19 pandemic, an outbreak of MP infection occurred from summer onwards in 2023 with children in Shanghai, China. Immunity debt and high rate of macrolide-resistance may take effects in this MP epidemic. Continuous surveillance of MP is necessary to help to alert the prevalence of MPP.
Mapping brain morphology to cognitive deficits: a study on PD-CRS scores in Parkinson’s disease with mild cognitive impairment
Authors: Brandão Pedro Renato , Pereira Danilo Assis , Grippe Talyta Cortez , Bispo Diógenes Diego de Carvalho , Maluf Fernando Bisinoto , Titze-de-Almeida Ricardo , de Almeida e Castro Brenda Macedo , Munhoz Renato Puppi , Tavares Maria Clotilde Henriques , Cardoso Francisco
Published: August 2024

Background

The Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) is a widely used tool for detecting mild cognitive impairment (MCI) in Parkinson’s Disease (PD) patients, however, the neuroanatomical underpinnings of this test’s outcomes require clarification. This study aims to: (a) investigate cortical volume (CVol) and cortical thickness (CTh) disparities between PD patients exhibiting mild cognitive impairment (PD-MCI) and those with preserved cognitive abilities (PD-IC); and (b) identify the structural correlates in magnetic resonance imaging (MRI) of overall PD-CRS performance, including its subtest scores, within a non-demented PD cohort.

Materials and methods

This study involved 51 PD patients with Hoehn & Yahr stages I–II, categorized into two groups: PD-IC (n = 36) and PD-MCI (n = 15). Cognitive screening evaluations utilized the PD-CRS and the Montreal Cognitive Assessment (MoCA). PD-MCI classification adhered to the Movement Disorder Society Task Force criteria, incorporating extensive neuropsychological assessments. The interrelation between brain morphology and cognitive performance was determined using FreeSurfer.

Results

Vertex-wise analysis of the entire brain demonstrated a notable reduction in CVol within a 2,934 mm2 cluster, encompassing parietal and temporal regions, in the PD-MCI group relative to the PD-IC group. Lower PD-CRS total scores correlated with decreased CVol in the middle frontal, superior temporal, inferior parietal, and cingulate cortices. The PD-CRS subtests for Sustained Attention and Clock Drawing were associated with cortical thinning in distinct regions: the Clock Drawing subtest correlated with changes in the parietal lobe, insula, and superior temporal cortex morphology; while the PD-CRS frontal-subcortical scores presented positive correlations with CTh in the transverse temporal, medial orbitofrontal, superior temporal, precuneus, fusiform, and supramarginal regions. Additionally, PD-CRS subtests for Semantic and Alternating verbal fluency were linked to CTh changes in orbitofrontal, temporal, fusiform, insula, and precentral regions.

Conclusion

PD-CRS performance mirrors neuroanatomical changes across extensive fronto-temporo-parietal areas, covering both lateral and medial cortical surfaces, in PD patients without dementia. The observed changes in CVol and CTh associated with this cognitive screening tool suggest their potential as surrogate markers for cognitive decline in PD. These findings warrant further exploration and validation in multicenter studies involving independent patient cohorts.
Geo-demographic trends in nontraumatic subarachnoid hemorrhage-related mortality among older adults in the United States, 1999–2020
Authors: McCandless Martin G. , Dharia Anand A. , Wicks Elizabeth E. , Camarata Paul J.
Published: August 2024

Introduction

Nontraumatic subarachnoid hemorrhage (ntSAH) often results from a ruptured aneurysm and correlates with significant morbidity and mortality, particularly among the older population. Despite its impact, limited comprehensive studies evaluate the longitudinal trends in ntSAH-related mortality in older adults in the United States (US).

Methods

The authors conducted a retrospective analysis using the CDC WONDER database from 1999 to 2020, analyzing Multiple Cause-of-Death Public Use death certificates to identify ntSAH as a contributing factor in the death of adults aged 65 years and older. We calculated age-adjusted mortality rates (AAMR) and annual percent change (APC) to examine trends across demographic variables such as sex, race/ethnicity, urbanization, and states/census region.

Results

A total of 78,260 ntSAH-related deaths (AAMR 8.50 per 100,000 individuals) occurred among older adults in the US from 1999 to 2020. The overall AAMR for ntSAH decreased from 9.98 in 1999 to 8.67 in 2020 with an APC of −0.7% [95% CI (−1.0, −0.3)]. However, the authors observed a noticeable rise from 2013 to 2020 with an APC of 1.7% [95% CI (0.8, 2.6)]. Sex, racial, and regional disparities were evident with higher mortality rates for ages 85 or greater (crude mortality rate 16.6), women (AAMR 9.55), non-Hispanic Asian or Pacific Islander (AAMR 12.5), and micropolitan areas (AAMR 8.99), and Western US (AAMR 8.65).

Conclusion

Mortality from ntSAH increases with age, affects women disproportionately, and occurs more often in an inpatient setting. These findings necessitate targeted, multi-dimensional health policies and clinical interventions. Specialties beyond neurosurgery can utilize this data for improved risk stratification and early treatment. Policymakers should focus on equitable resource allocation and community-level interventions to mitigate these trends effectively.
CAPS: a simple clinical tool for β-amyloid positivity prediction in clinical Alzheimer syndrome
Authors: Lahiri Durjoy , Seixas-Lima Bruna , Roncero Carlos , Verhoeff Nicolaas Paul , Freedman Morris , Al-Shamaa Sarmad , Chertkow Howard
Published: August 2024

Introduction

With the advent of anti-β-amyloid therapies, clinical distinction between Aβ + and Aβ− in cognitive impairment is becoming increasingly important for stratifying referral and better utilization of biomarker assays.

Methods

Cognitive profile, rate of decline, neuropsychiatric inventory questionnaire (NPI-Q), and imaging characteristics were collected from 52 subjects with possible/probable AD.

Results

Participants with Aβ+ status had lower baseline MMSE scores (24.50 vs. 26.85, p = 0.009) and higher total NPI-Q scores (2.73 vs. 1.18, p < 0.001). NPI-Q score was found to be the only independent predictor for β-amyloid positivity (p = 0.008). A simple scoring system, namely Clinical β-Amyloid Positivity Prediction Score (CAPS), was developed by using the following parameters: NPI-Q, rapidity of cognitive decline, and white matter microangiopathy. Data from 48 participants were included in the analysis of accuracy of CAPS. CAP Score of 3 or 4 successfully classified Aβ + individuals in 86.7% cases.

Discussion

Clinical β-Amyloid Positivity Prediction Score is a simple clinical tool for use in primary care and memory clinic settings to predict β-amyloid positivity in individuals with clinical Alzheimer Syndrome can potentially facilitate referral for Anti Aβ therapies.
Mining Alzheimer’s disease clinical data: reducing effects of natural aging for predicting progression and identifying subtypes
Authors: Han Tian , Peng Yunhua , Du Ying , Li Yunbo , Wang Ying , Sun Wentong , Cui Lanxin , Peng Qinke
Published: August 2024

Introduction

Because Alzheimer’s disease (AD) has significant heterogeneity in encephalatrophy and clinical manifestations, AD research faces two critical challenges: eliminating the impact of natural aging and extracting valuable clinical data for patients with AD.

Methods

This study attempted to address these challenges by developing a novel machine-learning model called tensorized contrastive principal component analysis (T-cPCA). The objectives of this study were to predict AD progression and identify clinical subtypes while minimizing the influence of natural aging.

Results

We leveraged a clinical variable space of 872 features, including almost all AD clinical examinations, which is the most comprehensive AD feature description in current research. T-cPCA yielded the highest accuracy in predicting AD progression by effectively minimizing the confounding effects of natural aging.

Discussion

The representative features and pathogenic circuits of the four primary AD clinical subtypes were discovered. Confirmed by clinical doctors in Tangdu Hospital, the plaques (18F-AV45) distribution of typical patients in the four clinical subtypes are consistent with representative brain regions found in four AD subtypes, which further offers novel insights into the underlying mechanisms of AD pathogenesis.
Aberrant generation of dentate gyrus granule cells is associated with epileptic susceptibility in p53 conditional knockout mice
Authors: Ruiz-Reig Nuria , Chehade Georges , Yerna Xavier , Durá Irene , Gailly Philippe , Tissir Fadel
Published: August 2024

Neuronal apoptosis is a mechanism used to clear the cells of oxidative stress or DNA damage and refine the final number of neurons for a functional neuronal circuit. The tumor suppressor protein p53 is a key regulator of the cell cycle and serves as a checkpoint for eliminating neurons with high DNA damage, hyperproliferative signals or cellular stress. During development, p53 is largely expressed in progenitor cells. In the adult brain, p53 expression is restricted to the neurogenic niches where it regulates cell proliferation and self-renewal. To investigate the functional consequences of p53 deletion in the cortex and hippocampus, we generated a conditional mutant mouse (p53-cKO) in which p53 is deleted from pallial progenitors and their derivatives. Surprisingly, we did not find any significant change in the number of neurons in the mutant cortex or CA region of the hippocampus compared with control mice. However, p53-cKO mice exhibit more proliferative cells in the subgranular zone of the dentate gyrus and more granule cells in the granular cell layer. Glutamatergic synapses in the CA3 region are more numerous in p53-cKO mice compared with control littermates, which correlates with overexcitability and higher epileptic susceptibility in the mutant mice.
Research progress on the role of PTEN deletion or mutation in the immune microenvironment of glioblastoma
Authors: Du Leiya , Zhang Qian , Li Yi , Li Ting , Deng Qingshan , Jia Yuming , Lei Kaijian , Kan Daohong , Xie Fang , Huang Shenglan
Published: August 2024

Recent advances in immunotherapy represent a breakthrough in solid tumor treatment but the existing data indicate that immunotherapy is not effective in improving the survival time of patients with glioblastoma. The tumor microenvironment (TME) exerts a series of inhibitory effects on immune effector cells, which limits the clinical application of immunotherapy. Growing evidence shows that phosphate and tension homology deleted on chromosome ten (PTEN) plays an essential role in TME immunosuppression of glioblastoma. Emerging evidence also indicates that targeting PTEN can improve the anti-tumor immunity in TME and enhance the immunotherapy effect, highlighting the potential of PTEN as a promising therapeutic target. This review summarizes the function and specific upstream and downstream targets of PTEN-associated immune cells in glioblastoma TME, providing potential drug targets and therapeutic options for glioblastoma.
Supervisory performance in telework: the role of job demands, resources, and satisfaction with telework
Authors: Peiró José M. , Bravo-Duarte Felipe , González-Anta Baltasar , Todolí-Signes Adrián
Published: August 2024

Introduction

Digitalization and the pandemic have transformed work, increasing flexibility, and remote arrangements. A critical factor in these transformations' success is supervisors' competencies. Consequently, new tools for assessing supervisory performance are required, particularly considering subordinates' evaluations. This study investigates the role of three telework resources (structural support, telework readiness, and monitorization) and three demands (workload, isolation, and information overload) in predicting employees' evaluation of supervisors, with satisfaction with telework as a moderator.

Methods

A survey among 322 Spanish teleworkers was conducted in July 2023. Specific scales for measuring Telework Supervisory Performance, as well as Telework Resources and Demands, were developed. Confirmatory Factor Analysis (CFA), correlations, and Structural Equation Modeling (SEM) were conducted.

Results

Organizational structural support positively correlates with subordinates' evaluation of their supervisor, while monitorization shows a negative relationship. Telework demands studied demonstrated no significant relationship with the outcome. Interaction effects between resources and satisfaction with telework increased the relationship with supervisor evaluations.

Discussion

This research shows that organizational support significantly enhances supervisor evaluations in remote work settings, particularly among satisfied teleworkers. The findings also reveal that high monitoring levels can negatively impact supervisor assessments. Conversely, job demands were not significantly linked to supervisor evaluations. Implications for workers and organizations are discussed.
The double-edged nature of nicotine: toxicities and therapeutic potentials
Authors: Cao Yun , Sun Jiali , Wang Xiaofeng , Zhang Xiaoyu , Tian Huijuan , Huang Lingling , Huang Ze , Zhang Yaping , Zhang Jin , Li Lin , Zhou Shun
Published: August 2024

Nicotine is the primary addictive component of cigarette smoke and is associated with various smoking-related diseases. However, recent research has revealed its broader cognitive-enhancing and anti-inflammatory properties, suggesting its potential therapeutic applications in several conditions. This review aims to examine the double-edged nature of nicotine, encompassing its positive and negative effects. We provide a concise overview of the physiochemical properties and pharmacology of nicotine, including insights into nicotine receptors. Therefore, the article is divided into two main sections: toxicity and therapeutic potential. We comprehensively explored nicotine-related diseases, focusing on specific signaling pathways and the underlying mechanisms that contribute to its effects. Furthermore, we addressed the current research challenges and future development perspectives. This review aims to inspire future researchers to explore the full medical potential of nicotine, which holds significant promise for the clinical management of specific diseases.
Effects of an online mindfulness-based cognitive therapy for caregivers of children with allergic rhinitis
Authors: Yan Xixi , Xiong Zhongwei , Sun Huimin , Li Jieli , Gao Yadong , Zhang Jinjin , Ding Xiaomin
Published: August 2024

The incidence of allergic rhinitis in children is high across the world, as well as in China. Allergic rhinitis in children has serious impact on physical and mental health of the children. At the same time, the caregivers of allergic rhinitis children have heavy burden of care, and their mental problems are severe. It is necessary to implement timely psychological intervention for the caregivers of allergic rhinitis children. Mindfulness-Based Cognitive Therapy (MBCT) is a safe and effective psychological therapy, and the effect of online intervention can be comparable to the traditional face-to-face intervention program. This study focused on the mental health status in the main caregivers of children with allergic rhinitis, and conducted a modified online MBCT intervention on the caregivers, in order to improve their adverse mental state, meanwhile, improve the quality of care they provide. The results show that online MBCT intervention is applicable to the main caregivers of children with allergic rhinitis, and can effectively reduce caregiver burden, relieve anxiety and depression, and improve the level of mindfulness in the caregivers.
Mind over matter: mindfulness as a buffer against workplace incivility
Authors: Huseynova Gonchakhanim , İslamoğlu Mehmet
Published: August 2024

This study examines the relationship between co-worker incivility, emotional exhaustion, mindfulness, and turnover intention among nurses in public and private hospitals in North Cyprus. Drawing upon the Job Demand-Resources theory, the research aims to contribute to the existing literature by investigating the mediating role of emotional exhaustion and the moderating effect of mindfulness on the relationship between co-worker incivility and turnover intention. Data were collected from 238 nurses through questionnaires, and structural equation modeling was employed for data analysis. The results indicate a positive association between co-worker incivility and emotional exhaustion, as well as between co-worker incivility and turnover intention. Emotional exhaustion was found to mediate the relationship between co-worker incivility and turnover intention. Furthermore, mindfulness was identified as a moderator, attenuating the negative impact of co-worker incivility on turnover intention. The findings underscore the importance of addressing workplace incivility and promoting mindfulness to mitigate turnover intentions among nurses. Practical implications include the implementation of interventions to foster a supportive work environment and enhance nurses' emotional wellbeing.
Preoperative early-stage lung cancer patients and local brain area changes: a cross-sectional observational descriptive study
Authors: Yuan Pei-Pei , Hua Xu-Yun
Published: August 2024

Introduction

Lung cancer is a major global health concern. Patients undergo a substantial process of emotional transformation following a lung cancer diagnosis, during which subtle changes in brain function and/or structure may occur. As such, the present study aimed to investigate the neuroplastic changes induced by negative emotions in patients with early-stage lung cancer.

Methods

This cross-sectional study recruited 35 patients with early-stage lung cancer and 33 age- and sex-matched healthy control patients. All participants completed the Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and functional magnetic resonance imaging (fMRI). Amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) were used as the fMRI indices. Correlations between the clinical assessments and ALFF and ReHo values were calculated.

Results

Our analysis revealed no significant differences in HAMD and HAMA scores between patients and control patients (p > 0.05). However, significant alterations in ALFF and ReHo were observed in multiple brain regions in patients with early-stage lung cancer compared to healthy controls (PFalseDiscoveryRate < 0.05). Specifically, ALFF values were decreased in the right postcentral gyrus, calcarine, and left middle cingulate, while ReHo values increased in the right angular gyrus and decreased in the bilateral postcentral gyrus, insula, left calcarine, putamen, superior temporal gyrus, middle cingulate, and right Rolandic gyrus. The HAMD score was significantly correlated with the ALFF value in the right postcentral gyrus (P = 0.007).

Conclusion

This study provides valuable insights into the adaptive responses of the brain following the early diagnosis of lung cancer, revealing potential disturbances in negative emotional processing. Harnessing neuroplasticity may open new avenues for the establishment of personalized treatment strategies and targeted interventions to support the emotional and mental health of patients with lung cancer.
Dynamic analysis of the relationship between systemic lupus erythematosus disease activity and psychosocial support
Authors: Lu Miao , Liu Min , Zhan Kuijun , Chen Yutong , Liu Xide
Published: August 2024

Background

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease that significantly affects both the physical and mental health of patients. Psychosocial support systems play a crucial role in managing chronic diseases, yet their specific impact on the disease activity of SLE patients remains unclear. This study aims to explore the dynamic relationship between disease activity in SLE patients and various types of psychosocial support systems.

Methods

We conducted a retrospective longitudinal observational study, including 150 SLE patients who received treatment at our hospital from January 2022 to January 2023. Emotional support, tangible support, social interaction support, and informational support were assessed using the revised Social Support Rating Scale. Disease activity was quantified using the European Consensus Lupus Activity Measurement. The relationship between psychosocial support and disease activity was analyzed using Spearman’s rank correlation coefficient and multiple linear regression models, with Bootstrap resampling employed to test the robustness of the results.

Results

We found a significant negative correlation between psychosocial support and SLE disease activity, with emotional support, social interaction support, and informational support showing stronger negative correlations. Multiple regression analysis revealed that the inhibitory effects of emotional support, social interaction support, and informational support on disease activity increased over time. Although the impact of tangible support was not statistically significant, it gradually became more apparent over time.

Conclusion

Our findings indicate a significant negative correlation between psychosocial support and SLE disease activity, particularly with emotional support, social interaction support, and informational support. Over time, the impact of tangible support also becomes evident. These findings provide important references for the comprehensive treatment and management of SLE patients. However, due to the observational nature of the study, the causality of this relationship requires further exploration.
The relationship between adolescents’ physical activity, circadian rhythms, and sleep
Authors: Liu Daoli , He Jin , Li Hengfen
Published: August 2024

Objective

To explore the correlation between physical activity, circadian rhythms, and sleep in adolescents, and analyze the influencing factors of sleep quality in this population.

Methods

A total of 381 high school students were selected through cluster sampling in a specific high school. The Pittsburgh Sleep Quality Index (PSQI) was employed to categorize the participants into a good sleep quality group (n=199) and a poor sleep quality group (n=182). Comprehensive assessments were conducted using the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), PSQI, Morningness-Eveningness Questionnaire-5 (MEQ-5), and International Physical Activity Questionnaire Short Form (IPAQ-SF).

Results

The prevalence of poor sleep quality is 47.8%. The BMI in the poor sleep quality group is higher than that in the good sleep quality group, and the male ratio is lower than that in the good sleep quality group. The poor sleep quality group exhibits significantly higher levels of depression, anxiety, evening chronotype, and low physical activity compared to the good sleep quality group.Spearman rank correlation analysis revealed a positive correlation between the PSQI total score and HAMA and HAMD scores, and a negative correlation with physical activity and MEQ-5 scores. Binary logistic stepwise regression analysis identified lack of physical activity, eveningness chronotype, anxiety, and depression as risk factors for poor sleep quality.

Conclusion

Adolescent sleep quality is correlated with gender, BMI, anxiety, depression, chronotype, and physical activity levels. The findings highlight the importance of considering these factors in interventions aimed at improving sleep health in adolescents.
The impact of parental migration patterns, timing, and duration on the health of rural Chinese children
Authors: Wang Feng , Wang Ying , Liu Shumei , Cui Linlin , Li Feimeng , Wang Xiaohe
Published: August 2024

Background

Parent–child separation raises concerns for the well-being of 69 million left-behind children (LBC) in China. However, the effects of parental migration status, timing of migration, and migration duration on the health of children remain unclear. This study aims to explore the association between different parent–child separation experience and a range of health outcomes in rural Chinese children.

Method

A sample of 2,355 students, grades 5 to 8, from two provinces in China were recruited. Standardized self-report instruments collected data on demographics, separation status, and children’s health conditions.

Results

Full data were available for 274 children with both parents currently migrating (BLBC), 638 children with one parent currently migrating (SLBC), 658 children with parents previously migrated (PLBC) and 785 children with non-migrating parents (NLBC). Regression model results showed that, compared to the NLBC group, BLBC and PLBC exhibited lower self-rated health (p < 0.05), higher depression (p < 0.05), and higher rates of non-suicidal self-injury behaviors (p < 0.05) and suicidal ideation (p < 0.05). Children who experienced parental separation before the age of three were at a higher risk for four health indicators. Additionally, children left behind by parents for more than 7 years had significantly worse health outcomes.

Conclusion

Children who have experienced both current and previous parental migration, as well as earlier parental migration age and longer migration duration, are at a disadvantage in terms of health. These findings highlight the need for targeted interventions focusing on the most vulnerable children.
Of course people can reject democracy: psychological perspectives
Authors: Newman Leonard S.
Published: August 2024

Concerns have been expressed about a worldwide retreat from liberal democracy and a turn toward more authoritarian forms of government. Along with that concern has come surprise: when the cold war ended, it was widely believed that a new historical era was dawning during which alternatives to Western liberalism would wither away. Influential psychological theories also assume that freedom and autonomy are powerful human needs—needs that are thwarted by dictatorships. However, a number of theoretical perspectives and programs of research in psychology lead to the conclusion that in certain circumstances, turns toward authoritarian forms of government and restrictive societies are not only explicable, but also predictable. Fromm's analysis of why people might want to escape from freedom, Baumeister's work on escape-from-self mechanisms, and Schwartz's review of the literature on choice overload all provide ways of understanding why in turbulent times, members of free countries might intentionally seek out—and perhaps even ecstatically embrace—authoritarian forms of government.
Impact of regional pest control on pesticide application in China from a perceived risks perspective
Authors: Xu Bin , Kong Fanzhu
Published: August 2024

The Regional Pest Control program represents a strategic intervention aimed at optimizing pesticide use in crop production, thereby mitigating the environmental impact of agricultural non-point source pollution from pesticides and fostering the development of high-quality agriculture. This study examines the influence of farmers’ perceived risks on the adoption of the Regional Pest Control program and evaluates its effect on pesticide application across a nationally representative dataset from Heilongjiang, Jiangsu, Anhui, Hubei, and Sichuan provinces. To account for unobserved heterogeneity, an endogenous switching regression model was employed. The findings reveal that farmers’ perceived risks associated with the Regional Pest Control program significantly deter its adoption. Furthermore, the program has been effective not only in reducing the frequency of pesticide applications but also in increasing the usage of pesticides with lower acute toxicity levels. Notably, the impact of the Regional Pest Control program on pesticide application demonstrates considerable variation in accordance with farmers’ risk attitudes.
Transitioning towards sustainable agriculture: analysing the factors and impact of adopting multiple sustainable inputs by paddy farmers in India
Authors: Jha Girish Kumar , Velayudhan Praveen Koovalamkadu , Bhatia Arti , Laishram Chinglembi , Kumar Deepak , Begho Toritseju , Eory Vera
Published: August 2024

Introduction

There is a global priority to ensure food security, environmental conservation and sustainability. The adoption of inputs such as organic manures, biofertilisers, and biopesticides has been widely promoted as a way to enhance agricultural sustainability, yet their adoption rates remain notably low. The study examines the determinants and impact of the adoption of multiple sustainable inputs by paddy farmers in India. The study also examines the drivers behind the intensity of their adoption and their technical efficiency.

Methods

The study utilises the survey dataset on paddy farmers from “Situation Assessment of Agricultural Households and Land and Livestock Holdings of Households in Rural India” of the 77th National Sample Survey (NSSO) round. The reference period for data collection was the agricultural year from July 2018 to June 2019. The analytical methods employed include the Multivariate Probit and Ordered Probit models, Seemingly Unrelated Regression, Regression Adjustment model, and Stochastic Frontier method.

Results

The empirical findings reveal that the adoption and intensity of sustainable inputs depend significantly on factors such as the household head’s age and education, household size, and access to extension services. Adopting sustainable inputs has significant benefits, such as increased harvest value. However, the currently available technical advisory services are limited in effectively promoting the expenditure on sustainable inputs. Technical efficiency analysis underscores the potential for improvement and the importance of utilising optimal input levels. The research findings provide strong evidence in favour of advocating for the use of sustainable inputs in paddy farming.
Predictive value of tip-apex distance and calcar-referenced tip-apex distance for cut-out in 398 femoral intertrochanteric fractures treated in a private practice with dynamic intramedullary nailing
Authors: Barra Amariel E. , Barrios Carlos
Published: August 2024

Introduction

Cut-out, a biomechanical complication, is one of the most common causes of internal fixation failure of trochanteric hip fractures. The tip-apex distance (TAD) and the calcar-referenced tip-apex distance (CalTAD) have been suggested as the radiographic parameters that most predict the risk of cut-out. The purpose of this study was to check whether these two factors could predict implant cut-out in a series 398 of intertrochanteric hip fractures, treated by dynamic intramedullary nailing with the Trigen Intertan short nail.

Methods

We reviewed 398 consecutive intertrochanteric fractures included in a prospective study and treated in a single private hospital by the same surgeon. The radiographic parameters were obtained from anteroposterior (AP) and axial hip plain radiographs before surgery, immediately postoperatively, and every 3 weeks after surgery until 3 months postoperatively, and every month until the 6-month follow-up. The concept of medial cortex support (MCS) was also analyzed as a criterion for evaluating the quality of fracture reduction.

Results

The overall cut-out rate was 2.3% (9/398). The significant parameters in the univariate analysis were AO fracture type, quality of fracture reduction (p = 0.02), TAD (p < 0.001), CalTAD (p = 0.001), and quality of reduction. No statistically significant relationships were observed between the occurrence of cut-out and sex, age, fracture side, and American Society of Anesthesiologists type. Varus collapse and cut-out were only found in cases of negative MCS (22.2% and 77.8%, respectively). Multivariate analysis showed that only TAD showed an independent significant relationship to cut-out (p < 0.001). In this study, CalTAD has no predictive value in the multivariable analysis.

Conclusions

Our findings differed from those in previous reported studies suggesting that CalTAD is the best predictor of cut-out. According to our data, careful optimal reduction ensuring stable fixation with TAD >25 mm reduced the occurrence of cut-out after dynamic intramedullary nailing of intertrochanteric fractures.