bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison study of athletic kinesio tapes and structural cloth tapes applied to address biomechanical injuries and muscle stabilization
Authors: Shannon Declan , Love Brian J
Published: June 2020

Quasi-static tensile and stress relaxation experiments were performed on several cloth-based and segmented elastomeric tapes, and the results were analyzed using viscoelastic models. The cloth tape modulus of elasticity was ∼340 MPa, while those of the kinesio tapes ranged from ∼15 to 20 MPa. The cloth tapes was also stronger and more brittle. Viscoelastic modeling of the stress relaxation behavior was done using a Zener model for the cloth tapes and a 5-element model for the kinesio tapes. The cloth tape relaxed by ∼20%, while the kinesio tapes relaxed by ∼40% of the applied maximum stress in approximately 300-s as demonstrated by viscoelastic modeling and constant strain experiments. The overall amount of long-term compressive force delivered by kinesio tapes might be inadequate for some applications, but they are more forgiving in how they are deployed.
Basal total testosterone serum levels predict biopsy and pathological ISUP grade group in a large cohort of Caucasian prostate cancer patients who underwent radical prostatectomy
Authors: Tafuri Alessandro , Sebben Marco , Rizzetto Riccardo , Amigoni Nelia , Shakir Aliasger , Processali Tania , Pirozzi Marco , Gozzo Alessandra , Odorizzi Katia , De Michele Mario , Gallina Sebastian , Bianchi Alberto , Ornaghi Paola Irene , Brunelli Matteo , Migliorini Filippo , Cerruto Maria Angela , Siracusano Salvatore , Artibani Walter , Antonelli Alessandro , Porcaro Antonio B.
Published: June 2020

Aims:

The study aimed to evaluate associations of preoperative total testosterone (TT) with the risk of aggressive prostate cancer (PCA).

Materials & methods:

From 2014 to 2018, basal TT levels were measured in 726 consecutive PCA patients. Patients were classified according to the International Society of Urologic Pathology (ISUP) system. Aggressive PCA was defined by the detection of ISUP > 2 in the surgical specimen. The logistic regression model evaluated the association of TT and other clinical factors with aggressive PCA.

Results:

On univariate analysis, there was a significant association of basal TT with the risk of aggressive PCA as well as age, prostate-specific antigen (PSA), percentage of biopsy positive cores (BPC), tumor clinical stage (cT), and biopsy ISUP grade groups. On multivariate analysis, two models were considered. The first (model I) excluded biopsy ISUP grading groups and the second (model II) included biopsy ISUP grade groups. Multivariate model I, revealed TT as well as all other variables, was an independent predictor of the risk of aggressive disease [odds ratio (OR) = 1.585; 95% confidence interval (CI): 1.113–2.256; p = 0.011]. Elevated basal PSA greater than 20 µg/dl was associated with the risk of aggressive PCA. Multivariate model II revealed that basal TT levels maintain a positive association between aggressive PCA, whereas age, BPC, and clinical stage cT3 lost significance. In the final adjusted model, the level of risk of TT did not change from univariate analysis (OR = 1.525; 95% CI: 1.035–2.245; p = 0.011).

Conclusion:

Elevated preoperative TT levels are associated with the risk of aggressive PCA in the surgical specimen. TT may identify patients who are at risk of aggressive PCA in the low and intermediate European Association of Urology (EAU) risk classes.
Exploring the fast food and planning appeals system in England and Wales: decisions made by the Planning Inspectorate (PINS)
Authors: O’Malley CL , Lake AA , Townshend TG , Moore HJ
Published: June 2020

Background:

The National Planning Policy Framework advocates the promotion of ‘healthy communities’. Controlling availability and accessibility of hot food takeaways is a strategy which the planning system may use to promote healthier environments. Under certain circumstances, for example, local authorities can reject applications for new hot food takeaways. However, these decisions are often subject to appeal. The National Planning Inspectorate decide appeals – by upholding or dismissing cases. The aim of this research is to explore and examine the National Planning Inspectorate’s decision-making.

Methods:

The appeals database finder was searched to identify hot food takeaway appeal cases. Thematic analysis of appeals data was carried out. Narrative synthesis provided an overview of the appeals process and explored factors that were seen to impact on the National Planning Inspectorate’s decision-making processes.

Results:

The database search identified 52 appeals cases. Results suggest there is little research in this area and the appeals process is opaque. There appears to be minimal evidence to support associations between the food environment and health and a lack of policy guidance to inform local planning decisions. Furthermore, this research has identified non-evidence-based factors that influence the National Planning Inspectorate’s decisions.

Conclusion:

Results from this research will provide public health officers, policy planners and development control planners with applied public health research knowledge from which they can draw upon to make sound decisions in evaluating evidence to ensure they are successfully equipped to deal with and defend hot food takeaway appeal cases.
Current smoking, former smoking, and adverse outcome among hospitalized COVID-19 patients: a systematic review and meta-analysis
Authors: Farsalinos Konstantinos , Barbouni Anastasia , Poulas Konstantinos , Polosa Riccardo , Caponnetto Pasquale , Niaura Raymond
Published: June 2020

Background:

The purpose of this study was to examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients.

Methods:

A systematic review of the literature (PubMed) identified 18 (from a total of 1398) relevant studies. Pooled current smoking prevalence was compared with the gender-adjusted and gender and age-adjusted, population-based expected prevalence by calculating prevalence odds ratio (POR). The association between current, compared with non-current and former, smoking and adverse outcome was examined. A secondary analysis was performed by including 12 pre-publications (30 studies in total). All analyses were performed using random-effects meta-analysis.

Results:

Among 6515 patients, the pooled prevalence of current smoking was 6.8% [95% confidence interval (CI): 4.8–9.1%]. The gender-adjusted POR was 0.20 (95% CI: 0.16–0.25, p < 0.001), and the gender and age-adjusted POR was 0.24 (95% CI: 0.19–0.30, p < 0.001). Current smokers were more likely to have an adverse outcome compared with non-current smokers [odds ratio (OR): 1.53, 95%CI: 1.06–2.20, p = 0.022] but less likely compared with former smokers (OR: 0.42, 95% CI: 0.27–0.74, p = 0.003). When pre-publications were added ( n = 10,631), the gender-adjusted POR was 0.27 (95% CI: 0.19–0.38, p < 0.001) and the gender and age-adjusted POR was 0.34 (95% CI: 0.24–0.48, p < 0.001).

Conclusion:

This meta-analysis of retrospective observational case series found an unexpectedly low prevalence of current smoking among hospitalized patients with COVID-19. Hospitalized current smokers had higher odds compared with non-current smokers but lower odds compared with former smokers for an adverse outcome. Smoking cannot be considered a protective measure for COVID-19. However, the hypothesis that nicotine may have a protective effect in COVID-19 that is partially masked by smoking-related toxicity and by the abrupt cessation of nicotine intake when smokers are hospitalized should be explored in laboratory studies and clinical trials using pharmaceutical nicotine products.
A case report of fibroadenoma of the breast with characteristic cystic change on a cut surface
Authors: Miyoshi Kazuya , Takahashi Hirotoshi , Inagaki Masaru , Watanabe Jiro , Yamada Sohsuke , Mizutani Kenichi
Published: June 2020

Fibroadenoma with remarkable cystic change is very unusual. Opinions differ as to the interpretation of this lesion. Furthermore, there have been few reports focusing on its macroscopic view. We herein report a case of fibroadenoma in a 43-year-old woman. The patient presented herself to a medical doctor’s office due to a rapidly growing breast tumor. Based on a core needle biopsy, a benign lesion was suspected, and the tumor was surgically resected. On a macroscopic study, the cut surface of the tumor revealed a remarkably cystic and well-circumscribed lesion with an intracystic polypoid component. Microscopically, a variety of findings of epithelial and stromal proliferation were observed. This is an interesting case not only because a fibroadenoma with prominent cystic change is unusual but also because the breast tumor showed a characteristically cystic appearance on its macroscopic view.
Consumers on Critique: A Survey of Classical Music Listeners’ Engagement with Professional Music Reviews
Authors: Alessandri Elena , Rose Dawn , Senn Olivier , Szamatulski Katrin , Baldassarre Antonio , Williamson Victoria Jane
Published: June 2020

Music criticism has a long tradition as a leading agent in the classical music discourse. However, some people question its function in the contemporary music market. We explored the topicality of classical music critique by asking: Who reads professional reviews today? And what do readers expect from review? Through an online survey (English/German), we profiled the listening habits of classical music listeners ( N = 1200) and their engagement with professional reviews. Our participants were more actively engaged with music, but contrary to the ‘highbrow’ stereotype, not more highly musically trained than the general population. They consumed music and opinion sources in a variety of ways. Approximately two-thirds ( n = 741) of the participants had recently engaged with professional reviews, which were perceived as the most useful form of opinion, followed by short written commentaries and, lastly, ratings. A multiple logistic regression model suggested that the typical consumer of professional music critique was older with higher levels of musical engagement and education, had a higher inclination to purchase music and lower usage of streaming services, and had a preference for detailed reviews from traditional sources (e.g. newspapers). According to review readers, reviews should cover a variety of topics and offer evaluations underpinned with reasons. Reviewers should be constructive, open-minded, respectful, and well informed; their professional background was less relevant. Professional reviews should not necessarily provide a recommendation on what to buy, but rather guide listeners’ musical appreciation and understanding. Professional criticism still has an audience, although more so among older, musically educated listeners. Critics need to explore various channels in order to connect to a new generation of classical music listeners.
Comparison of hypertrophic scarring on a red Duroc pig and a Guangxi Mini Bama pig
Authors: Ning Xiaoyu , Yang Kai , Shi Wei , Xu Chenjie
Published: June 2020

Pigs are the most promising models for the study of wound healing and hypertrophic scarring because they are anatomically and physiologically similar to human beings. The Red Duroc pig and Mini Bama pig are two swine models that have attracted a lot of attention. The aim of the present study was to examine and compare the scarring process in a red Duroc pig and a Mini Bama pig, providing knowledge for researchers and clinicians to enable them to choose the most suitable pig model for studies.
Joseph Needham’s inspiration for research on agricultural history in China
Authors: Wang Siming
Published: June 2020

Ancient Chinese civilization was agricultural. To grasp the essence of science and civilization in China, Dr Joseph Needham drew attention to its agricultural development. He maintained close academic relations with Chinese historians of agriculture and obtained their help from time to time for the compilation of his Science and Civilisation in China. Needham also had a far-reaching influence on research on the agricultural history of China, both on its institutionalization and on transitions in the directions of research. The so-called ‘Needham puzzle’ was first proposed systematically in his address titled ‘Science and agriculture in China and the West’ at the annual conference of the China Agronomic Association in Chongqing in 1943. He believed that science is not isolated from society but is an indivisible part of civilization and that civilization has evolved as the result of the interactions of science, society and the environment.
Themes Related to Experienced Quality of Care in Nursing Homes From the Resident’s Perspective: A Systematic Literature Review and Thematic Synthesis
Authors: Sion Katya Y. J. , Verbeek Hilde , Zwakhalen Sandra M. G. , Odekerken-Schröder Gaby , Schols Jos M. G. A. , Hamers Jan P. H.
Published: June 2020

Background: The culture change from task-centered care to person- and relationship-centered care has resulted in the resident’s voice gaining importance when assessing experienced quality of care in nursing homes. This review aimed to identify which factors contribute to experienced quality of care in nursing homes worldwide from the resident’s perspective. Method: A systematic literature review and thematic data synthesis were performed. The databases PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo, and Business Source Complete were searched to identify qualitative studies aimed at retrieving factors related to residents’ experienced quality of care in nursing homes. Only studies in which residents themselves were interviewed were included. Results: This literature review included 27 publications covering 14 countries. Thematic analysis revealed three overarching themes related to residents’ care experiences: (a) The nursing home environment consisted of the physical environment and caring environment, (b) individual aspects of living in the nursing home consisted of personhood and coping with change, and (c) social engagement consisted of meaningful relationships and care provision. Discussion: To achieve high experienced quality of care in nursing homes, residents’ care experiences need to be assessed and used in quality management.
The Peril of Acid Attacks in India and Susceptibility of Women
Authors: Goswami Shivani , Handa Rakesh Kumar
Published: June 2020

Acid attacks on women have become the most burning area and are considered to be the most nastiest and the most atrocious kind of violence committed on weaker sex. It is the thoughtful and pre-mediated use of acid on another human being for no blunder on her part. Reasons could be easy accessibility of acid, male-domineering and male-dictating society, antagonism, scorned and disdained lovers, etc., to name a few. Cases on acid attacks are mounting, swelling and escalating like anything. The perpetrators do not realize the consequences of such menacing, ominous and looming attacks on innocent victims and throw acids on them, distorting their face, limbs and different parts of body. It is high time now. Something stringent needs to be done to curb this evil in our society. Otherwise it will be too late, and innocent creatures on this earth will continue to suffer for no fault of theirs. The authors would be dealing with various facades, legal remedies and compensations dealing with acid attacks in the present society.
Prediction and prevention of central nervous system relapse in patients with extranodal natural killer/T-cell lymphoma
Authors: Kim Hyera , Jeong Hyehyun , Yamaguchi Motoko , Sohn Insuk , Yoon Sang Eun , Byeon Seonggyu , Hur Joon Young , Koh Youngil , Yoon Sung-Soo , Kim Eo Jin , Oguchi Masahiko , Miyazaki Kana , Taguchi Senzo , Yoon Dok Hyun , Cho Junhun , Ko Young Hyeh , Kim Seok Jin , Suzuki Ritsuro , Kim Won Seog
Published: June 2020

Because non–anthracycline-based chemotherapy with l-asparaginase has improved survival outcomes in patients with extranodal natural killer/T-cell lymphoma (ENKTL), the incidence of central nerve system (CNS) relapse can be different when compared with that in previous reports. In this research, we sought to identify the incidence of and predictors for CNS relapse and to evaluate the necessity of CNS prophylaxis with intermediate-dose methotrexate (ID-MTX). The records of 399 patients in the training cohort and 253 patients in the validation cohort with ENKTL who received non-anthracycline–based chemotherapy were reviewed. Patients were divided into 2 groups according to whether the chemotherapy regimen included ID-MTX above 2 g/m2. A new central nervous system-prognostic index of natural killer (CNS-PINK) model was developed using 1-point powerful predictors of CNS relapse (PINK; hazard ratio [HR], 2.908; P = .030 and extranodal involvement [≥2]; HR, 4.161; P = .001) and was calculated as a sum of scores. The high-risk group of CNS-PINK was defined as 2 points. The cumulative incidence of CNS relapse was different between the CNS-PINK risk groups in the training (P < .001) and validation (P = .038) cohorts. Patients in the high-risk CNS-PINK group who were treated with SMILE or SMILE-like regimens with ID-MTX (S-ID-MTX) displayed a lower incidence rate of CNS relapse than did those who received other regimens without ID-MTX in the training cohort (P = .029). The CNS-PINK was demonstrated its strong predictability of CNS relapse in ENKTL patients. The effectiveness of S-ID-MTX in preventing CNS events in high-risk CNS-PINK patients should be verified in future studies.
Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics
Authors: Porsbjerg Celeste M. , Sverrild Asger , Lloyd Clare M. , Menzies-Gow Andrew N. , Bel Elisabeth H.
Published: June 2020

Monoclonal antibody therapies have significantly improved treatment outcomes for patients with severe asthma; however, a significant disease burden remains. Available biologic treatments, including anti-immunoglobulin (Ig)E, anti-interleukin (IL)-5, anti-IL-5Rα and anti-IL-4Rα, reduce exacerbation rates in study populations by approximately 50% only. Furthermore, there are currently no effective treatments for patients with severe, type 2-low asthma. Existing biologics target immunological pathways that are downstream in the type 2 inflammatory cascade, which may explain why exacerbations are only partly abrogated. For example, type 2 airway inflammation results from several inflammatory signals in addition to IL-5. Clinically, this can be observed in how fractional exhaled nitric oxide (FeNO), which is driven by IL-13, may remain unchanged during anti-IL-5 treatment despite reduction in eosinophils, and how eosinophils may remain unchanged during anti-IL-4Rα treatment despite reduction inFeNO. The broad inflammatory response involving cytokines including IL-4, IL-5 and IL-13 that ultimately results in the classic features of exacerbations (eosinophilic inflammation, mucus production and bronchospasm) is initiated by release of “alarmins” thymic stromal lymphopoietin (TSLP), IL-33 and IL-25 from the airway epithelium in response to triggers. The central, upstream role of these epithelial cytokines has identified them as strong potential therapeutic targets to prevent exacerbations and improve lung function in patients with type 2-high and type 2-low asthma. This article describes the effects of alarmins and discusses the potential role of anti-alarmins in the context of existing biologics. Clinical phenotypes of patients who may benefit from these treatments are also discussed, including how biomarkers may help identify potential responders.
Comparative genomics of four strains of the edible brown alga, Cladosiphon okamuranus
Authors: Nishitsuji Koki , Arimoto Asuka , Yonashiro Yoshitaka , Hisata Kanako , Fujie Manabu , Kawamitsu Mayumi , Shoguchi Eiichi , Satoh Noriyuki
Published: June 2020

Background

The brown alga, Cladosiphon okamuranus (Okinawa mozuku), is one of the most important edible seaweeds, and it is cultivated for market primarily in Okinawa, Japan. Four strains, denominated S, K, O, and C, with distinctively different morphologies, have been cultivated commercially since the early 2000s. We previously reported a draft genome of the S-strain. To facilitate studies of seaweed biology for future aquaculture, we here decoded and analyzed genomes of the other three strains (K, O, and C).

Results

Here we improved the genome of the S-strain (ver. 2, 130 Mbp, 12,999 genes), and decoded the K-strain (135 Mbp, 12,511 genes), the O-strain (140 Mbp, 12,548 genes), and the C-strain (143 Mbp, 12,182 genes). Molecular phylogenies, using mitochondrial and nuclear genes, showed that the S-strain diverged first, followed by the K-strain, and most recently the C- and O-strains. Comparisons of genome architecture among the four strains document the frequent occurrence of inversions. In addition to gene acquisitions and losses, the S-, K-, O-, and C-strains possess 457, 344, 367, and 262 gene families unique to each strain, respectively. Comprehensive Blast searches showed that most genes have no sequence similarity to any entries in the non-redundant protein sequence database, although GO annotation suggested that they likely function in relation to molecular and biological processes and cellular components.

Conclusions

Our study compares the genomes of four strains of C. okamuranus and examines their phylogenetic relationships. Due to global environmental changes, including temperature increases, acidification, and pollution, brown algal aquaculture is facing critical challenges. Genomic and phylogenetic information reported by the present research provides useful tools for isolation of novel strains.
Is the positive association between middle-income and rich household wealth and adult sub-Saharan African women’s overweight status modified by the level of education attainment? A cross-sectional study of 22 countries
Authors: Ozodiegwu Ifeoma D. , Doctor Henry V. , Quinn Megan , Mercer Laina D. , Omoike Ogbebor Enaholo , Mamudu Hadii M.
Published: June 2020

Background

Previous studies show a positive association between household wealth and overweight in sub-Saharan African (SSA) countries; however, the manner in which this relationship differs in the presence of educational attainment has not been well-established. This study examined the multiplicative effect modification of educational attainment on the association between middle-income and rich household wealth and overweight status among adult females in 22 SSA countries. We hypothesized that household wealth was associated with a greater likelihood of being overweight among middle income and rich women with lower levels of educational attainment compared to those with higher levels of educational attainment.

Methods

Demographic and Health Survey (DHS) data from 2006 to 2016 for women aged 18–49 years in SSA countries were used for the study. Overweight was defined as a body mass index (BMI) ≥ 25 kg/m2. Household wealth index tertile was the exposure and educational attainment, the effect modifier. Potential confounders included age, ethnicity, place of residence, and parity. Descriptive analysis was conducted, and separate logistic regression models were fitted for each of the 22 SSA countries to compute measures of effect modification and 95% confidence intervals. Analysis of credibility (AnCred) methods were applied to assess the intrinsic credibility of the study findings and guide statistical inference.

Results

The prevalence of overweight ranged from 12.6% in Chad to 56.6% in Swaziland. Eighteen of the 22 SSA countries had measures of effect modification below one in at least one wealth tertile. This included eight of the 12 low-income countries and all 10 middle income countries. This implied that the odds of overweight were greater among middle-income and rich women with lower levels of educational attainment than those with higher educational attainment. On the basis of the AnCred analysis, it was found that the majority of the study findings across the region provided some support for the study hypothesis.

Conclusions

Women in higher wealth strata and with lower levels of educational attainment appear to be more vulnerable to overweight compared to those in the same wealth strata but with higher levels of educational attainment in most low- and middle- income SSA countries.
Renal pelvis and ureteropelvic junction incarceration in a Grynfeltt-Lesshaft hernia: a case report and review of the literature
Authors: Mehrabi Saadat , Yavari Barhaghtalab Mohammad Javad , Babapour Mehdi
Published: June 2020

Background

Grynfeltt–Lesshaft hernia is a kind of lumbar abdominal wall hernia in which clinical presentations may vary from an asymptomatic bulge in the lumbar area to a symptomatic lumbar mass with back pain. It has been accepted to be a rare entity, and incarceration of the kidney through this hernia is shown to be very rare, and very few previous cases have been reported in this regard.

We present a case of renal pelvic and ureteropelvic junction incarceration in a Grynfeltt-Lesshaft hernia and provide an overview of the existing literature on it.

Case presentation

A 76-year-old lady presented to the outpatient clinic with the chief complaint of right flank pain and swelling. Computed tomography (CT) scan of the abdomen was revealed a large herniated sac (60*30 mm) in the upper lumbar triangle with protrusion of retroperitoneal and omental fat, right renal pelvis, ureteropelvic junction and proximal ureter with consecutive hydronephrosis. Herniated retroperitoneal and omental fat was reduced, and closure of the abdominal wall defect was done using retro-muscular Mesh and was fixed to the fascia. The patient was discharged 24 h after the surgery without any complications.

Conclusion

Kidney herniation through the lumbar triangle is extremely rare, and the diagnosis requires careful clinical evaluation. CT scan is the modality of choice for the assessment. Management through surgery should be done in symptomatic patients.
State-dependent mortality can enhance behavioral unpredictability
Authors: Okuyama Toshinori
Published: June 2020

Background

Although behavioral unpredictability is widely described within-individual variability in behavior, its adaptive significance is little understood. Using a dynamic state variable model, this study investigated the conditions under which behavioral unpredictability (a component of within-individual variability) in foraging behavior is advantageous. The model considers a situation in which a forager forages for a fixed period, represented by discrete time steps. The outcome of foraging may change the level of a state (e.g., size and fat storage) of the forager at each time step, and variability in the foraging outcome is assumed to be positively correlated with behavioral unpredictability. The probability of death at each time step is influenced by the state at the same time step. Reproduction occurs after all the foraging steps and is influenced by the state level of a forager at the time of reproduction. According to the expected utility hypothesis, the relationship (e.g., curvature) between the state and fitness will determine the role of behavioral unpredictability. In the model, the relationship was obtained by using the backward iteration method for each foraging time step.

Results

State-dependent mortality adds curvature to the relationship between the state and fitness, which makes the effect of behavioral unpredictability on fitness either positive or negative. This conclusion holds for any state-dependent mortality (i.e., as long as mortality is not independent of the state factor). Given that state-dependent mortality is commonly described, conditions that benefit behavioral unpredictability are likely also common.

Conclusions

When mortality depends on a state that is influenced by behavior, conditions that favor behavioral unpredictability may become common. How behavioral unpredictability influences the variability of behavioral outcomes is as important as how it influences the expectation of behavioral outcomes when studying the adaptive significance of behavioral unpredictability.
A lipidome-wide association study of the lipoprotein insulin resistance index
Authors: Bagheri Minoo , Tiwari Hemant K. , Murillo Anarina L. , Al-Tobasei Rafet , Arnett Donna K. , Kind Tobias , Barupal Dinesh Kumar , Fan Sili , Fiehn Oliver , O’connell Jeff , Montasser May , Aslibekyan Stella , Irvin Marguerite R.
Published: June 2020

Background

The lipoprotein insulin resistance (LPIR) score was shown to predict insulin resistance (IR) and type 2 diabetes (T2D) in healthy adults. However, the molecular basis underlying the LPIR utility for classification remains unclear.

Objective

To identify small molecule lipids associated with variation in the LPIR score, a weighted index of lipoproteins measured by nuclear magnetic resonance, in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 980).

Methods

Linear mixed effects models were used to test the association between the LPIR score and 413 lipid species and their principal component analysis-derived groups. Significant associations were tested for replication with homeostatic model assessment-IR (HOMA-IR), a phenotype correlated with the LPIR score (r = 0.48,p <  0.001), in the Heredity and Phenotype Intervention (HAPI) Heart Study (n = 590).

Results

In GOLDN, 319 lipids were associated with the LPIR score (false discovery rate-adjustedp-valuesranging from 4.59 × 10− 161to 49.50 × 10− 3). Factors 1 (triglycerides and diglycerides/storage lipids) and 3 (mixed lipids) were positively (β = 0.025,p = 4.52 × 10− 71and β = 0.021,p = 5.84 × 10− 41, respectively) and factor 2 (phospholipids/non-storage lipids) was inversely (β = − 0.013,p = 2.28 × 10− 18) associated with the LPIR score. These findings were replicated for HOMA-IR in the HAPI Heart Study (β = 0.10,p = 1.21 × 10− 02for storage, β = − 0.13,p = 3.14 × 10− 04for non-storage, and β = 0.19,p = 8.40 × 10− 07for mixed lipids).

Conclusions

Non-storage lipidomics species show a significant inverse association with the LPIR metabolic dysfunction score and present a promising focus for future therapeutic and prevention studies.
Detecting and recording cardiac murmurs in clinically healthy puppies in first opinion veterinary practice at the first health check
Authors: van Staveren Marie Dirkje Beijken , Szatmári Viktor
Published: June 2020

Background

The frequency that cardiac murmurs are identified and recorded in first opinion veterinary practices at the first health check in puppies is unknown. The aims of the study were to assess the agreement between first opinion veterinary practitioners, a veterinary student and a veterinary cardiology specialist on detecting murmurs, and to establish whether abnormal auscultation findings had been recorded in the health certificates of clinically healthy puppies. The study included prospective and retrospective investigations, where the prospectively collected auscultation findings from a veterinary cardiology specialist and a trained veterinary student were compared to auscultation findings recorded by first opinion veterinary practitioners.

Results

Cardiac auscultation was performed on 331 client-owned, clinically healthy dogs at two time points: at age 34–69 days by a first opinion veterinary practitioner and at age 45–76 days, on average 9 days later, by a veterinary cardiology specialist and a trained veterinary student. Agreement among the three was compared for the presence of a murmur. The degree of inter-observer agreement was evaluated using Cohen’s kappa. Auscultation findings, as noted in the pets’ passports, from 331 puppies and 43 different first opinion veterinary practices, were retrospectively reviewed and prospectively compared with auscultation findings from a veterinary cardiology specialist. Agreement between the veterinary cardiology specialist and the first opinion veterinary practitioners was poor (ϰ = 0.01) and significantly different (P < 0.001). First opinion veterinary practitioners had recorded a cardiac murmur in only 1 of the 97 puppies in which the veterinary cardiology specialist detected a murmur. Two-hundred-and-fifty-two puppies were auscultated by both the veterinary cardiology specialist and the student. Their agreement was fair (ϰ = 0.40) and significantly different (P = 0.024). The agreement between the student and a first opinion veterinary practitioner on these 252 puppies was poor (ϰ = 0.03) and significantly different (P < 0.001).

Conclusions

This study shows that soft cardiac murmurs are rarely documented during the first veterinary health check in puppies by first opinion veterinary practitioners. Although soft murmurs may not be clinically relevant, finding and recording them is evidence of a carefully performed auscultation. Missing a non-pathological murmur is not of clinical importance; however, missing a pathological murmur could prove detrimental for the individual puppy.
Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial
Authors: Fan Dazhi , Zeng Meng , Xia Qing , Wu Shuzhen , Ye Shaoxin , Rao Jiaming , Lin Dongxin , Zhang Huishan , Ma Huiting , Han Zhongchao , Guo Xiaoling , Liu Zhengping
Published: June 2020

Background

Pathological skin scars, caused by cesarean section, affected younger mothers esthetically and psychosocially and to some extent frustrated obstetricians and dermatologists. Umbilical cord mesenchymal stem cells (UC-MSCs), as a population of multipotent cells, are abundant in human tissues, providing several possibilities for their effects on skin scar tissues. Herein, we performed a randomized, double-blind, placebo-controlled, three-arm clinical trial, aiming to assess the efficacy and safety of UC-MSCs in the treatment of cesarean section skin scars among primiparous singleton pregnant women.

Methods

Ninety primiparous singleton pregnant women undergoing elective cesarean section were randomly allocated to receive placebo, low-dose (3 × 106 cells), or high-dose (6 × 106 cells) transdermal hydrogel UC-MSCs on the surface of the skin incision. The primary outcome was cesarean section skin scars followed after the sixth month, assessed by the Vancouver Scar Scale (VSS).

Results

All the participants completed their trial of the primary outcome according to the protocol. The mean score of estimated total VSS was 5.52 in all participants at the sixth-month follow-up, with 6.43 in the placebo group, 5.18 in the low-dose group, and 4.71 in the high-dose group, respectively. No significant difference was found between-group in the mean scores for VSS at the sixth month. Additional prespecified secondary outcomes were not found with significant differences among groups either. No obvious side effects or adverse effects were reported in any of the three arms.

Conclusion

This randomized clinical trial showed that UC-MSCs did not demonstrate the effects of improvement of cesarean section skin scars.

Trial registration

ClinicalTrials.gov identifier, NCT02772289. Registered on 13 May 2016.
Measuring acceleration fields via regularized digital image correlation
Authors: Le Gourriérec Corentin , Roux Stéphane , Hild François
Published: June 2020

Digital image correlation (DIC) is a full-field measurement technique. In instantaneous approaches (i.e., registering two images), DIC only gives access to displacement (or velocity) fields. Consequently, acceleration fields are not one of the primary measured variables. To evaluate acceleration fields, a regularization scheme has to be used. The latter may be either heuristic or mechanically motivated. The key idea of the paper is to use spatiotemporal analyses in order to explicitly measure acceleration fields. Various regularization schemes will be assessed, and their relative merits will be studied when performing uncertainty quantifications. Pyrotechnic cutting simulations will provide a set of artificial pictures to be studied in order to validate the new implementations. This analysis enables the measurement performances to be evaluated for the new implementations.
A “messy ball of wool”: a qualitative study of the dimensions of the lived experience of obesity
Authors: Ogden Kathryn , Barr Jenny , Rossetto Georgia , Mercer John
Published: June 2020

Background

Obesity is a multi-dimensional condition with causal factors beyond the physiological into the behavioural, dietetic and psychological. Understanding the lived experience of those who are overweight and obese and self-perceived barriers to access and engagement in intervention are imperative to formulating a systemic response to the complex problem of obesity. This study aims to identify the social, psychological and systemic factors impeding engagement with weight-loss behaviour and interventions, and to formulate a framework for responding to these.

Methods

We conducted an exploratory qualitative study using focus groups and interviews with people who have lived experienced of being overweight or obese. Data were analysed using an inductive thematic approach. Following the thematic analysis, further interpretation of the data was achieved by applying the epistemological foundations of the Lifeworld Led Care paradigm, recognising its philosophy of the person and of care based on the individual’s experiences. Eight men and 17 women participated.

Results

Three overarching themes were identified: Complexity and Battle, Impediments, and Positive Re-orientation. The subthemes of these were found to represent the dimensions of the Lifeworld: Identify, Inter-subjectivity, Mood and Embodiment.

Further interpretation of the themed data identified six polarised dichotomies representing the opposing lived dimensions of the obesity experience: Failure Double-Bind; Think-Feel Conflict; Negative-Positive Orientation; Impeding-Facilitating Health Professional; Knowledge as Deficit-Insight; and Internal-External Orientation.

Conclusion

Obesity manifests as constraints and challenges across six polarised dichotomies, active in the lived experience of obesity. This study provides a unique way of conceptualising and understanding the complex and interacting meanings of the lived experience of obesity through the construction of polarised dichotomies. The polarities signify the oscillating experiences that people with obesity encounter, which may be either helpful or destructive in both their lifeworld experience and their capacity to address obesity towards improved social, psychological and physical outcomes. Understanding the dichotomies allows a reconceptualisation of obesity from a quantification of the individual to a more respectful, humane, compassionate and utilitarian conceptualisation of the experiencing person and the phenomenon itself. Further, these lived polarised dichotomies of obesity present the opportunity for health professionals to reconceptualise obesity in care and interventions.
Immigration policy mismatches and counterproductive outcomes: unauthorized migration to the U.S. in two eras
Authors: Massey Douglas S.
Published: June 2020

The world appears to be moving into a new era of international migration during which gaps between policies needed to manage migratory flows and those enacted in practice will widen. Whereas immigrants in the late 20th century were motivated by a desire to improve their wellbeing by accessing opportunities in richer countries, in the early 21st century they are increasingly motivated by a desire to escape threats at places of origin, yielding very different patterns of migration and selectivity. Using the United States as an example, this paper reviews how mismatches between the underlying realities of international migration and the policies adopted to manage them, in both eras have produced and continue to produce dysfunctional outcomes. Although deleterious policy outcomes might be avoided in the future by combining a well-grounded conceptual understanding of the forces producing immigration with a clear statement of the goals to be achieved through specific policy interventions, the avoidance of further dysfunctional outcomes is unlikely to be achieved in an age of rising populism, disinformation, and xenophobia.
Parameters matter: modulating cytokines using nerve stimulation
Authors: Bonaz Bruno
Published: June 2020

The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients with rheumatoid arthritis and inflammatory bowel disease have demonstrated the efficacy of targeting neural circuits as an efficient alternative to drug treatments. However, the optimal vagus nerve stimulation parameters to achieve efficacious symptomatic relief for inflammation are still unknown. In this issue of Bioelectronic Medicine, Tsaava et al. tested whether altering these electrical stimulation parameters would change circulating cytokine levels in healthy mice. They found that specific combinations of parameters produced significant increases in serum TNF while other parameters selectively lowered serum TNF levels, as compared to sham stimulated mice. These results have considerable implications for determining the optimal stimulation parameters to better treat common conditions and diseases that involve immune regulation.
Routine Blood Tests in Asymptomatic Patients With Indolent Lymphoma Have Limited Ability to Detect Clinically Significant Disease Progression
Authors: Piercey Oliver A. , Loh Zoe , Chan Joanna , Chong Geoff , Grigg Andrew , Cheema Steven , Gill Gurjot , Whybird Matthew , Cushion Tania , Hawkes Eliza A.
Published: June 2020

PURPOSE:

Patients with indolent non-Hodgkin lymphoma (iNHL) undergo regular active surveillance in between treatment periods to detect disease relapse or progression. As part of surveillance, international guidelines recommend regular routine blood testing, which is based on consensus rather than evidence of utility.

METHODS:

We conducted a retrospective analysis of all patients older than age 16 years diagnosed with grade 1-3A follicular or marginal zone lymphoma between 2008 and 2017 from 2 Australian cancer centers to assess the utility of full blood examination, lactate dehydrogenase, and β2-microglobulin in detecting progression events, defined as either disease relapse or progression of disease.

RESULTS:

One hundred eighty patients attended 1,757 outpatient appointments (median follow-up, 36 months). Routine blood tests (RBTs) were performed before 83% of appointments. Seventy-four progression events occurred in 62 patients. Only 2 events (3%) were detected by RBTs alone, both of which occurred in treatment-naïve patients who subsequently developed symptoms within 3 weeks. The remainder of progression events were suspected clinically (88%) or detected by imaging (9%). RBT results were frequently abnormal in asymptomatic patients (19%), with abnormal results leading to either additional investigations or an increased surveillance frequency in 8% of cases. The overall sensitivity and positive predictive value of abnormal RBT results in detecting progression events were 39% and 9%, respectively.

CONCLUSION:

RBTs have poor performance characteristics and rarely detect clinically significant disease progression or relapse in asymptomatic patients with iNHL.
Immune Checkpoint Inhibitor–Mediated Diarrhea and Colitis: A Clinical Review
Authors: Gong Zimu , Wang Yinghong
Published: June 2020

Immune-mediated diarrhea and colitis (IMDC) is among the most common immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors (ICIs). Many factors will affect the risk of IMDC, including the type of ICI used, the type of underlying cancer, and patient characteristics. A recent study showed that preexisting inflammatory bowel disease significantly increases the risk of diarrhea and colitis with ICI treatment. In terms of management, early endoscopic evaluation improves clinical outcome by identifying high-risk patients who will benefit from early add-on immunosuppressants. Inflammatory markers, including fecal lactoferrin and calprotectin, are good screening tools to predict which patients are at risk for colitis. Calprotectin especially is associated with colitis outcome and can be used as a surrogate marker to follow treatment response. Corticosteroids remain the first-line medical treatment of IMDC management, and add-on therapy with vedolizumab or infliximab should be considered in selected patients. Fecal microbiota transplantation may be considered in refractory cases. The decision to resume ICI should be decided by balancing the risk of recurrent IMDC and the likelihood of benefiting from further ICI treatment. There is no clear evidence about whether the use of immunosuppressants will result in a worse cancer outcome. With emerging evidence, our understanding and management strategies are likely to evolve in the future.
“Coyote Broke the Dams”: Power, Reciprocity, and Conflict in Fish Weir Narratives and Implications for Traditional and Contemporary Fisheries
Authors: Ritchie Morgan , Angelbeck Bill
Published: June 2020

This article examines the social and political implications of the geographically widespread and cross-cultural oral narratives related to the releases of salmon into the rivers of the Pacific Northwest through the destruction of weir-dams. Key themes in these narratives provide insights into indigenous concepts of reciprocity and authority, which in turn reveal dimensions of social organization and intercommunity interactions from a new perspective. These narratives explicitly foreground the inevitable tensions between communities that relied on salmon and also sought to prioritize their own interests, seeking exclusive use of weirs, occasionally to the detriment of other groups. This study illustrates how these narratives convey episodes of contradictory interests, exploitation, social struggle, reconciliation, and a moral charter for communities over a broad area. The analysis also highlights how the messages of these narratives are just as pertinent today as they were in the past.
Clear Indistinct Ideas: Disability, Vision, and the Diaphanous Body in Joyce’s Ulysses
Authors: Colangelo Jeremy
Published: June 2020

Although disability studies researchers have long recognized the interdependence of ability and disability as socially mediated categories, few studies have taken the next logical step of examining how ability is constructed and represented in literary texts. This article pursues that line of inquiry through an analysis of the representation of vision and its limitations in James Joyce’s Ulysses, arguing that the textual construction of ability arises through the myth of the diaphanous abled body—or the assumption that nondisabled experience occurs absent bodily interference—as it relates to an analogous formal process here named the sensorytextual screen. The author shows how presumptions of what constitutes an abled body inflect the (dis)abled realism of Joyce’s novel, which at once depicts and mocks ableist presumptions. Representations of blindness, sight, and low vision thus relate intimately with modernist experiments with description and literary point of view and do so at a very fundamental level.
On Cosmopolitanism, Xenophobia, and Migration
Authors: Searle Berni
Published: June 2020

The author/artist provides twenty images from three of her performance and video series: Home and Away (2003), Seeking Refuge (2008), and Mute (2008), complementing them with descriptions of the creative process and the collective experiences the images depict. Themes of identity, migration, displacement, loss, and vulnerability provide a stark contrast to the hopeful possibility of cosmopolitanism.