bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful liver transplantation in a patient recovered from COVID‐19
Authors: Dhand Abhay , Bodin Roxana , Wolf David C. , Schluger Aaron , Nabors Christopher , Nog Rajat , Diflo Thomas , Nishida Seigo
Published: October 2020

Transplantation in potential candidates who have recently recovered from COVID‐19 is a challenge with uncertainties regarding the diagnosis, multi‐organ systemic involvement, prolonged viral shedding in immunocompromised patients, and optimal immunosuppression. A 42 year male with alcoholic hepatitis underwent a successful deceased donor liver transplantation 71 days after the initial diagnosis of COVID‐19. At the time of transplant, he was SARS‐CoV‐2 PCR negative for 24 days and had a MELD score of 33. His post‐operative course was complicated by acute rejection which responded to intense immune‐suppression using T‐cell depletion and steroids. He was discharged with normal end‐organ function and no evidence of any active infection including COVID‐19. Prospective organ transplant recipients who have recovered from COVID‐19 can be considered for transplantation after careful pre‐transplant evaluation, donor selection, and individualized risk‐benefit analysis.
Furosemide administration onehour before bone scintigraphy examination in horses does not improve the image quality or reduce the radiation dose rate
Authors: Mageed Mahmoud , Wegert Julius , Dyab Shahlaa , Gerlach Kerstin
Published: October 2020

This prospective, cross‐sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on the image quality of bone scintigraphy performed using 99mTc‐HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty‐one horses undergoing bone scintigraphy were included. The horses were divided into the control (n = 14) and furosemide group (n = 17), which received 1 mg/kg furosemide intravenously 1 h post 99mTc‐HDP administration. The image quality was assessed subjectively and semi‐quantitatively. The bone‐to‐soft tissue (B:S) ratio was calculated from the counts per pixel of regions of interest (ROI) positioned over the left radial diaphysis (bone ROI) and its caudal soft tissue area (soft tissue ROI). The radiation rate dose (μSv/h) of both groups was measured at 0, 3, 6, 12, 18, and 24 h post 99mTc‐HDP administration at a distance of 0, 30, and 100 cm from the head, kidney, and pelvis. The results showed no significant differences in the B:S ratio or the radiation dose rate observed between the groups. However, the radiation dose rate decreased by 56% at 3 h post 99mTc‐HDP administration and keeping a distance of 30 cm reduced the radiation dose rate by 65%. Administering furosemide does not improve the image quality or reduce the radiation dose rate. The authors recommend commencing with bone scintigraphy 3 h post 99mTc‐HDP administration and keeping at least a distance of 30 cm from the horse to reduce the staff radiation dose.
First report of Ixodes lividus (Koch,1844) in sand martins Riparia riparia in Portugal

Authors: Pascoal Da Silva Luís , Isabel Lopes De Carvalho , Rita De Sousa , Cláudia Norte Ana
Published: October 2020

Ixodes lividus Koch, 1844 (Ixodida: Ixodidae) is a specialised endophilic tick of the sand martin Riparia riparia whose distributional range matches that of its host in the Paleartic region. However, the presence of this tick species has not been described in Mediterranean countries where the sand martin also breeds. In this study, we investigated I. lividus infestation in 1,081 Riparia riparia individuals from two breeding colonies in central Portugal. In total, three I. lividus were collected from three sand martins (infestation rate of 0.28%). A molecular survey on these ticks did not detect the presence of any Borrelia burgdorferi s.l., Rickttesia spp. nor Babesia spp. This report expands to the south and west the known distributional range of I. lividus in Europe.
A new crenobiontic water mite species of the genus Atractides Koch, 1837 from Montenegro and Bulgaria, based on morphological and molecular data (Acariformes, Hydrachnidia, Hygrobatidae)
Authors: Pešić Vladimir , Zawal Andrzej , Bańkowska Aleksandra , Jovanović Milica , Dabert Miroslawa
Published: October 2020

A new species of water mites from Montenegro and Bulgaria, Atractides anae Pešić sp. nov., is described, combining traditional morphological techniques with the analysis of partial mtDNA COI sequences (DNA-barcodes). Based on our molecular and morphological analysis, the new species is most closely related to the crenobiontic A. pennatus (K. Viets 1920) from which it differs by 6.4 (SD = 1.12)% K2P distance. A dataset including the novel COI sequences of 10 Atractides species from Montenegro and Iran is assembled in order to facilitate further studies on the genus by using molecular tools.
Two new species of the genus Bloszykiella (Acari: Uropodidae) from the Afrotropical region

Authors: Kontschán Jenő , Ermilov Sergey G.
Published: October 2020

Two new Bloszykiella species are discovered and described from the Afrotropical realm. Bloszykiella rammsteini sp. nov. (from Zimbabwe) differs from its congeners in the sculptural pattern of the dorsal shield, the strongly sclerotized U-shaped grooves on the dorsal shield and pilose dorsal setae. Bloszykiella lindemanni sp. nov. (from Rwanda) differs from the other species in the shape of the sternal setae, setae on the apical margin of the pygidial shield and the sculptural pattern of the female genital shield.
Contribution to the knowledge of oribatid mites of the genus Phyllhermannia (Acari, Oribatida, Hermanniidae) in Taiwan

Authors: Ermilov Sergey G. , Liao Jhih-rong
Published: October 2020

This work includes taxonomic and faunistic data on the oribatid mite genus Phyllhermannia (Oribatida, Hermanniidae) in Taiwan. One new species is described on the basis of adult specimens; Phyllhermannia shikongensis sp. nov. differs from all species of the genus by the presence of prodorsal hump on the prodorsum. Phyllhermannia pulchra Aoki, 1973 is recorded in the Oriental region for the first time; this species is redescribed and its main morphological traits are summarized. An identification key to species of Phyllhermannia of Taiwan and adjacent continental territory (China) is provided.
A new villain in neuronal death
Authors: Jones Susan
Published: October 2020

A newly discovered partnership for glutamate triggers brain toxicity
Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an
In Vitro
Pharmacokinetic/Pharmacodynamic Model
Authors: Kebriaei Razieh , Lev Katherine L. , Stamper Kyle C. , Lehman Susan M. , Morales Sandra , Rybak Michael J.
Published: October 2020

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs)
in vitro
in 24-h time-kill settings and in
ex vivo
simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant
Staphylococcus aureus
(MRSA) infections.
Molecular Epidemiology of Escherichia coli Producing CTX-M and pAmpC β-Lactamases from Dairy Farms Identifies a Dominant Plasmid Encoding CTX-M-32 but No Evidence for Transmission to Humans in the Same Geographical Region
Authors: Findlay Jacqueline , Mounsey Oliver , Lee Winnie W. Y. , Newbold Nerissa , Morley Katy , Schubert Hannah , Gould Virginia C. , Cogan Tristan A. , Reyher Kristen K. , Avison Matthew B.
Published: October 2020

Third-generation cephalosporins (3GCs) are critically important antibacterials, and 3GC resistance (3GC-R) threatens human health, particularly in the context of opportunistic pathogens such as
Escherichia coli
. There is some evidence for zoonotic transmission of 3GC-R
E. coli
through food, but little work has been done examining possible transmission via interaction of people with the local near-farm environment. We characterized acquired 3GC-R
E. coli
found on dairy farms in a geographically restricted region of the United Kingdom and compared these with
E. coli
from people living in the same region, collected in parallel. While there is strong evidence for recent farm-to-farm transmission of 3GC-R strains and plasmids—including one epidemic plasmid that has a remarkable capacity to be transmitted—there was no evidence that 3GC-R
E. coli
found on study farms had a significant impact on circulating 3GC-R
E. coli
strains or plasmids in the local human population.
The Extracellular Polysaccharide Matrix of Pseudomonas aeruginosa Biofilms Is a Determinant of Polymorphonuclear Leukocyte Responses
Authors: Rybtke Morten , Jensen Peter Østrup , Nielsen Claus Henrik , Tolker-Nielsen Tim
Published: October 2020

Bacterial biofilms may cause chronic infections due to their ability to evade clearance by the immune system and antibiotics. The persistent biofilms induce a hyperinflammatory state that damages the surrounding host tissue. Knowledge about the components of biofilms that are responsible for provoking the harmful but inefficient immune response is limited. Flagella are known to stimulate the response of polymorphonuclear leukocytes (PMNs) to planktonic solitary bacteria. However, we provide evidence that flagella are not a prerequisite for the response of PMNs toPseudomonas aeruginosabiofilms.
Treatment success of internet-based vestibular rehabilitation in general practice: development and internal validation of a prediction model
Authors: van Vugt Vincent A , Heymans Martijn W , van der Wouden Johannes C , van der Horst Henriëtte E , Maarsingh Otto R
Published: October 2020

Objectives

To develop and internally validate prediction models to assess treatment success of both stand-alone and blended online vestibular rehabilitation (VR) in patients with chronic vestibular syndrome.

Design

Secondary analysis of a randomised controlled trial.

Setting

59 general practices in The Netherlands.

Participants

202 adults, aged 50 years and older with a chronic vestibular syndrome who received either stand-alone VR (98) or blended VR (104). Stand-alone VR consisted of a 6-week, internet-based intervention with weekly online sessions and daily exercises. In blended VR, the same intervention was supplemented with physiotherapy support.

Main outcome measures

Successful treatment was defined as: clinically relevant improvement of (1) vestibular symptoms (≥3 points improvement Vertigo Symptom Scale—Short Form); (2) vestibular-related disability (>11 points improvement Dizziness Handicap Inventory); and (3) both vestibular symptoms and vestibular-related disability. We assessed performance of the predictive models by applying calibration plots, Hosmer-Lemeshow statistics, area under the receiver operating characteristic curves (AUC) and applied internal validation.

Results

Improvement of vestibular symptoms, vestibular-related disability or both was seen in 121, 81 and 64 participants, respectively. We generated predictive models for each outcome, resulting in different predictors in the final models. Calibration for all models was adequate with non-significant Hosmer-Lemeshow statistics, but the discriminative ability of the final predictive models was poor (AUC 0.54 to 0.61). None of the identified models are therefore suitable for use in daily general practice to predict treatment success of online VR.

Conclusion

It is difficult to predict treatment success of internet-based VR and it remains unclear who should be treated with stand-alone VR or blended VR. Because we were unable to develop a useful prediction model, the decision to offer stand-alone or blended VR should for now be based on availability, cost effectiveness and patient preference.

Trial registration number

The Netherlands Trial Register NTR5712.
Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial–mesenchymal transition in breast cancer cells via the miR-136–Smad3 axis
Authors: Leng Xiaoling , Huang Guofu , Ding Jianbing , Ma Fucheng
Published: October 2020

Circular RNAs (circRNAs) are tissue-specific RNAs with a more stable structure than linear RNAs, and their association with breast cancer (BC) is poorly understood. This study examined the biological effects of circ_0000043 in the progression of BC. In this study, expression of circ_0000043 in BC tissue samples was measured using quantitative real-time polymerase chain reaction. Immunohistochemistry and Western blot were used to detect the expression of Smad family member 3 (Smad3). CCK-8, wound healing, and Transwell assays were used to assess the effect of circ_0000043 on the proliferation, migration, and invasiveness of BC cells. Moreover, the binding relationships between circ_0000043 and miR-136, and miR-136 and Smad3 were detected by dual-luciferase reporter assay. Additionally, Western blot was used to detect the expressions of markers related to epithelial–mesenchymal transition, including E-cadherin, N-cadherin, and vimentin. Our results show that the expression of circ_0000043 is up-regulated in BC tissues and cell lines. The proliferation, migration, invasiveness, and epithelial–mesenchymal transition of BC cells were significantly inhibited by knockdown of circ_0000043, and overexpression of circ_0000043 had the opposite effects. Additionally, circ_0000043 up-regulate the expression of Smad3 by sponging miR-136. In conclusion, our study demonstrates that circ_0000043 promote the progression of BC via regulating the miR-136–Smad3 axis.
Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKCδ–NLRC4 axis
Authors: Yang Fan , Yang Yinhui , Zeng Weihui
Published: October 2020

Anti-double-stranded DNA (anti-dsDNA) is closely associated with the inflammatory burden in the brain after ischemic stroke. Here, we studied the inflammatory cascade and investigated the mechanisms behind the pro-inflammatory role of dsDNA in systemic lupus erythematosus (SLE). The serum levels of interleukin-1beta (IL-1β) and IL-6 in SLE patients and the corresponding controls were evaluated using ELISA, and the expression level of caspase-1 was evaluated using quantitative real-time polymerase chain reaction (qRT-PCR). We found that the serum levels of IL-1β and IL-6 were increased in the SLE patients. The expression of caspase-1 was upregulated and positively correlated with the levels of pro-inflammatory factors. The level of anti-dsDNA was also elevated and positively correlated with the results for the mean fluorescence intensity (MFI) of caspase-1. Additionally, we evaluated the functions of PRKCD encoding protein kinase c delta (PKCδ) and NLRC4, in vivo, in MRL/Faslpr mice. We found that renal injury was aggravated, and the levels of pro-inflammatory factors were increased in the MRL/Faslpr mice. We also found that increased levels of NLRC4 in the mice exacerbated renal injury and increased the levels of pro-inflammatory factors, whereas inhibition of PKCδ had the opposite results. These findings provide unique perspectives on pathogenesis of SLE and indicate that inhibition of anti-dsDNA could attenuate renal inflammatory burden, representing a promising therapeutic opportunity for SLE.
A gauge theory that mixes Bosonic and Fermionic gauge fields
Authors: McKeon D.G.C.
Published: October 2020

Using a gauge symmetry derived by applying the Dirac constraint formalism to supergravity with a cosmological term in 2 + 1 dimensions, we construct a gauge theory with many characteristics of Yang–Mills theory. The gauge transformation mixes two Bosonic fields and one Fermionic field.
Modulation of hydrogen sulfide synthesis improves heart function and endothelium-dependent vasorelaxation in diabetes
Authors: Dorofeyeva N.A. , Korkach I.P. , Kutsyk O.E. , Sagach V.F.
Published: October 2020

Diabetes dramatically increases the risk of cardiovascular complications. The endothelial dysfunction and diastolic heart dysfunction are associated with a decreasing level of hydrogen sulfide (H2S) and inhibition of the activity of endothelial nitric oxide synthase (NOS) in diabetes. The aim of this study is to investigate the effect of modulation of H2S synthesis on heart functions and vasorelaxation in diabetes. The dl-propargylglycine and l-cysteine were administered intraperitoneally. H2S content in the heart tissue, markers of oxidative stress, inducible NOS and constitutive NOS (cNOS) activities, endothelium-dependent vasorelaxation of the aortic rings, and heart function were studied. We demonstrate that our combination increased H2S synthesis 13 times and cNOS activity 5 times in the heart tissue of diabetic rats. Increasing NO and H2S production caused improvement and restoration of endothelium-dependent relaxation of aorta, effective arterial elastance, and diastolic heart function in diabetic rats. The endothelium-dependent relaxation increased 2.4 times; effective arterial elastance decreased by 47%. The end-diastolic myocardial stiffness decreased 2.2 times. Thus, modulation of H2S synthesis leads to increased cNOS activity by up to 5 times in the cardiovascular system. Increasing NO and H2S production restored endothelium-dependent relaxation of aorta and improved heart function in diabetes.
A model-independent constraint on the Hubble constant with gravitational waves from the Einstein Telescope
Authors: Zhang Sixuan , Cao Shuo , Zhang Jia , Liu Tonghua , Liu Yuting , Geng Shuaibo , Lian Yujie
Published: October 2020

In this paper, we investigate the expected constraints on the Hubble constant from the gravitational-wave standard sirens, in a cosmological-model-independent way. In the framework of the well-known Hubble law, the GW signal from each detected binary merger in the local universe ([Formula: see text]) provides a measurement of luminosity distance [Formula: see text] and thus the Hubble constant [Formula: see text]. Focusing on the simulated data of gravitational waves from the third-generation gravitational wave detector (the Einstein Telescope, ET), combined with the redshifts determined from electromagnetic counter parts and host galaxies, one can expect the Hubble constant to be constrained at the precision of [Formula: see text] with 20 well-observed binary neutron star (BNS) mergers. Additional standard-siren measurements from other types of future gravitational-wave sources (NS-BH and BBH) will provide more precision constraints of this important cosmological parameter. Therefore, we obtain that future measurements of the luminosity distances of gravitational waves sources will be much more competitive than the current analysis, which makes it expectable more vigorous and convincing constraints on the Hubble constant in a cosmological-model-independent way.
Computer Vision-based Methodology to Improve Interaction for People with Motor and Speech Impairment
Authors: Ascari Rúbia E. O. Schultz , Pereira Roberto , Silva Luciano
Published: October 2020

Augmentative and Alternative Communication (AAC) aims to complement or replace spoken language to compensate for expression difficulties faced by people with speech impairments. Computing systems have been developed to support AAC; however, partially due to technical problems, poor interface, and limited interaction functions, AAC systems are not widespread, adopted, and used, therefore reaching a limited audience. This article proposes a methodology to support AAC for people with motor impairments, using computer vision and machine learning techniques to allow for personalized gestural interaction. The methodology was applied in a pilot system used by both volunteers without disabilities, and by volunteers with motor and speech impairments, to create datasets with personalized gestures. The created datasets and a public dataset were used to evaluate the technologies employed for gesture recognition, namely the Support Vector Machine (SVM) and Convolutional Neural Network (using Transfer Learning), and for motion representation, namely the conventional Motion History Image and Optical Flow-Motion History Image (OF-MHI). Results obtained from the estimation of prediction error using K-fold cross-validation suggest SVM associated with OF-MHI presents slightly better results for gesture recognition. Results indicate the technical feasibility of the proposed methodology, which uses a low-cost approach, and reveals the challenges and specific needs observed during the experiment with the target audience.
Bacillus anthracis edema toxin inhibits hypoxic pulmonary vasoconstriction via edema factor and cAMP-mediated mechanisms in isolated perfused rat lungs
Authors: Cui Xizhong , Wang Jeffrey , Li Yan , Couse Zoe G. , Risoleo Thomas F. , Moayeri Mahtab , Leppla Stephen H. , Malide Daniela , Yu Zu-Xi , Eichacker Peter Q.
Published: October 2020

The most important findings here are edema toxin’s potent adenyl cyclase activity can interfere with hypoxic pulmonary vasoconstriction, an action that could worsen hypoxemia during invasive anthrax infection with lung involvement. These findings, coupled with other studies showing that lethal toxin can disrupt pulmonary vascular integrity, indicate that both toxins can contribute to pulmonary pathophysiology during infection. In combination, these investigations provide a further basis for the use of antitoxin therapies in patients with worsening invasive anthrax disease.
IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases
Authors: Capel Rebecca A. , Bose Samuel J. , Collins Thomas P. , Rajasundaram Skanda , Ayagama Thamali , Zaccolo Manuela , Burton Rebecca-Ann Beatrice , Terrar Derek A.
Published: October 2020

This study provides evidence supporting the proposal that IP3 signaling in cardiac atria and sinoatrial node involves stimulation of Ca2+-activated adenylyl cyclases (AC1 and AC8) by IP3-evoked Ca2+ release from junctional sarcoplasmic reticulum. AC8 and IP3 receptors are shown to be located close together, while AC1 is nearby. Greater understanding of these novel aspects of the IP3 signal transduction mechanism is important for future study in atrial physiology and pathophysiology, particularly atrial fibrillation.
Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D‐Galactose and Aβ25–35‐Induced Rat Model of Alzheimer’s Disease
Authors: Deng Shaodong , Lu Hongmei , Chi Honggang , Wang Ying , Li Xiao , Ye Haiyi
Published: October 2020

Morinda officinalis F.C. How. (Rubiaceae) is a herbal medicine. It has been recorded that its oligosaccharides have neuroprotective properties. In order to understand the oligosaccharides extracted from Morinda officinalis (OMO), a systematic study was conducted to provide evidence that supports its use in neuroprotective therapies for Alzheimer’s disease (AD). AD rat models were prepared with D‐galactose and Aβ25–35. The following groups were used in the present experiment: normal control group, sham‐operated group, model group, Aricept group, OMO low‐dose group, OMO medium‐dose group, and OMO high‐dose group. The effects on behavioral tests, antioxidant levels, energy metabolism, neurotransmitter levels, and AD‐related proteins were detected with corresponding methodologies. AD rats administered with different doses of OMO all exhibited a significant (P < 0.05) decrease in latency and an increase (P < 0.05) in the ratio of swimming distance to total distance in a dose‐dependent manner in the Morris water maze. There was a significant (P < 0.05) increase in antioxidant enzyme activities (SOD, GSH‐Px, and CAT), neurotransmitter levels (acetylcholine, γ‐GABA, and NE and DA), energy metabolism (Na+/K+‐ATPase), and relative synaptophysin (SYP) expression levels in AD rats administered with OMO. Furthermore, there was a significant (P < 0.05) decrease in MDA levels and relative expression levels of APP, tau, and caspase‐3 in AD rats with OMO. The present research suggests that OMO protects against D‐galactose and Aβ25–35‐induced neurodegeneration, which may provide a novel strategy for improving AD in clinic.
A Two-Phase Cloud Resource Provisioning Algorithm for Cost Optimization
Authors: Chen Junjie , Li Hongjun
Published: October 2020

Cloud computing is a new computing paradigm to deliver computing resources as services over the Internet. Under such a paradigm, cloud users can rent computing resources from cloud providers to provide their services. The goal of cloud users is to minimize the resource rental cost while meeting the service requirements. In reality, cloud providers often offer multiple pricing models for virtual machine (VM) instances, including on-demand and reserved pricing models. Moreover, the workload of cloud users varies with time and is not known a priori. Therefore, it is challenging for cloud users to determine the optimal cloud resource provisioning. In this paper, we propose a two-phase cloud resource provisioning algorithm. In the first phase, we formulate the resource reservation problem as a two-stage stochastic programming problem, and solve it by the sample average approximation method and the dual decomposition method. In the second phase, we propose a hybrid ARIMA-Kalman model to predict the workload, and determine the number of on-demand instances based on the predicted workload. The effectiveness of the proposed two-phase algorithm is evaluated using a real-world workload trace and Amazon EC2’s pricing models. The simulation results show that the proposed algorithm can significantly reduce the operational cost while guaranteeing the service level agreement (SLA).
Construction and Analysis of lncRNA‐Mediated ceRNA Network in Nasopharyngeal Carcinoma Based on Weighted Correlation Network Analysis
Authors: Zou Zhenning , Liu Shuguang , Ha Yanping , Huang Bowan
Published: October 2020

Increasing evidence indicated that aberrant expression of long noncoding RNAs (lncRNAs) are involved in tumorigenesis of nasopharyngeal carcinoma (NPC). The purpose of this study was to construct a lncRNA‐mediated ceRNA network based on weighted correlation network analysis (WGCNA). First, modules with highly correlated genes were identified from GSE102349 via WGCNA, and the preservation of the modules was evaluated by GSE68799. Then, the differentially expressed lncRNAs and mRNAs identified from GSE12452 which belonged to the same WGCNA modules and the differentially expressed miRNAs identified from GSE32960 were used to construct a ceRNA network. The prognostic value of the network was evaluated by survival analysis. Furthermore, a risk score model for predicting progression‐free survival (PFS) of NPC patients was established via LASSO‐penalized Cox regression, and the differences in the expression of the lncRNAs between high‐ and low‐risk groups were investigated. Finally, 14 stable modules were identified, and a ceRNA network composed of 11 lncRNAs, 15 miRNAs, and 40 mRNAs was established. The lncRNAs and mRNAs in the network belonged to the turquoise and salmon modules. Survival analysis indicated that ZNF667‐AS1, LDHA, LMNB2, TPI1, UNG, and hsa‐miR‐142‐3p were significantly correlated with the prognosis of NPC. Gene set enrichment analysis indicated that the upregulation of ZNF667‐AS1 was associated with some immune‐related pathways. Besides, a risk score model consisting of 12 genes was constructed and showed a good performance in predicting PFS for NPC patients. Among the 11 lncRNAs in the ceRNA network, SNHG16, SNHG17, and THAP9‐AS1 were upregulated in the high‐risk group of NPC, while ZNF667‐AS1 was downregulated in the high‐risk group of NPC. These results will promote our understanding of the crosstalk among lncRNAs, miRNAs, and mRNAs in the tumorigenesis and progression of NPC.
An Adaptive Network Model to Simulate Consensus Formation Driven by Social Identity Recognition
Authors: Zhang Kaiqi , Lv Zinan , Du Hai Feng , Zou Honghui
Published: October 2020

Models of the consensus of the individual state in social systems have been the subject of recent research studies in the physics literature. We investigate how network structures coevolve with the individual state under the framework of social identity theory. Also, we propose an adaptive network model to achieve state consensus or local structural adjustment of individuals by evaluating the homogeneity among them. Specifically, the similarity threshold significantly affects the evolution of the network with different initial conditions, and thus there emerges obvious community structure and polarization. More importantly, there exists a critical point of phase transition, at which the network may evolve into a significant community structure and state-consistent group.
An Integrated DEMATEL-ANP Approach for Mobile Banking Adoptions in China Market
Authors: Zhu Xiaoning , Yan Rui , Xu Tian xing
Published: October 2020

With the rapid development of the mobile device and Internet usage, the mobile banking has seen remarkable growth across the world, especially in the past few years, as one of the emerging financial innovations. This paper attempts to explore the mobile banking services offered by selected commercial Chinese banks. The main data of this study were obtained through the comprehensive evaluation of mobile banking services. The DEMATEL-ANP method was used to evaluate the main factors influencing the adoption of mobile banking. The results show that there is still big space for the improvement of the mobile banking services for the selected Chinese banks. The management significance and suggestions for these banks are also discussed.
Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders
Authors: Chen Shu , Hu Qin , Chen Hong , Zhang Fei-Fei , Duan Liang , Wang Bo , Li Dan-Dan , Zhang Juan , Chen Wei-Xian
Published: October 2020

Substantial advance supports that CMTM2 serve as an important performer in physiological and pathological processes. However, very little is clear about the relationship between CMTM2 and HBV-related disorders. Here, for the first time, we explore that whether or not serum CMTM2 is involved in HBV-related diseases. We found that CMTM2 values were significantly lower in patients compared to healthy control (p <0.001), using ELISA assay. Furthermore, serum CMTM2 levels were negatively correlated with HBV DNA levels in CHB patients but not correlated with the serum levels of ALT and AST. Serum CMTM2 concentrations were not correlated with the serum levels of ALT, AST and HBV DNA load in HBLC and HCC patients. In addition, analysis of the ROC curve indicated that CMTM2 levels were significantly associated with the diagnostic value of HBV-related disorders. Finally, downregulation of CMTM2 was observed in HBV-infected cell model. CMTM2 degradation could be attributed to HBx-activated Lys48 (K48)-linked polyubiquitination, which was abolished by treatment with the proteasome inhibitor MG132. HBV infection suppresses CMTM2 expression by activating ubiquitin-proteasome system. Serum CMTM2 levels can be adopted as an effective indicator of the pathogenesis of HBV-related disorders.
The Role of Prognostic and Predictive Biomarkers for Assessing Cardiovascular Risk in Chronic Kidney Disease Patients
Authors: Provenzano Michele , Andreucci Michele , De Nicola Luca , Garofalo Carlo , Battaglia Yuri , Borrelli Silvio , Gagliardi Ida , Faga Teresa , Michael Ashour , Mastroroberto Pasquale , Serraino Giuseppe Filiberto , Licastro Noemi , Ielapi Nicola , Serra Raffaele
Published: October 2020

Chronic kidney disease (CKD) is currently defined as the presence of proteinuria and/or an eGFR < 60 mL/min/1.73m2 on the basis of the renal diagnosis. The global dimension of CKD is relevant, since its prevalence and incidence have doubled in the past three decades worldwide. A major complication that occurs in CKD patients is the development of cardiovascular (CV) disease, being the incidence rate of fatal/nonfatal CV events similar to the rate of ESKD in CKD. Moreover, CKD is a multifactorial disease where multiple mechanisms contribute to the individual prognosis. The correct development of novel biomarkers of CV risk may help clinicians to ameliorate the management of CKD patients. Biomarkers of CV risk in CKD patients are classifiable as prognostic, which help to improve CV risk prediction regardless of treatment, and predictive, which allow the selection of individuals who are likely to respond to a specific treatment. Several prognostic (cystatin C, cardiac troponins, markers of inflammation, and fibrosis) and predictive (genes, metalloproteinases, and complex classifiers) biomarkers have been developed. Despite previous biomarkers providing information on the pathophysiological mechanisms of CV risk in CKD beyond proteinuria and eGFR, only a minority have been adopted in clinical use. This mainly depends on heterogeneous results and lack of validation of biomarkers. The purpose of this review is to present an update on the already assessed biomarkers of CV risk in CKD and examine the strategies for a correct development of biomarkers in clinical practice. Development of both predictive and prognostic biomarkers is an important task for nephrologists. Predictive biomarkers are useful for designing novel clinical trials (enrichment design) and for better understanding of the variability in response to the current available treatments for CV risk. Prognostic biomarkers could help to improve risk stratification and anticipate diagnosis of CV disease, such as heart failure and coronary heart disease.
Fasting Plasma Glucose and Coronary Heart Disease in a Rural Population of North Henan, China
Authors: Guo Quan , Lin Fei , Liu Yi , Li Yang , Wang Xue-Hui , Chen Zhi-Gang , Lv Feng-Hua , Zhang Yong-Chun , Yuan Yu , Zhao Guo-An
Published: October 2020

Even in individuals without diabetes, the incidence of coronary heart disease (CHD) increases with the rise in fasting plasma glucose (FPG); however, the threshold of FPG for CHD in rural areas of China is unclear. We retrospectively examined 2,987 people. Coronary angiography records were used to determine the presence of CHD as well as its severity. Risk factors for CHD and the relationship between different levels of FPG and CHD were analyzed. After adjusting for age, hypertension, dyslipidemia, smoking, drinking, chronic kidney disease, and previous ischemic stroke, the incidence of CHD in nondiabetic women began to increase when FPG exceeded 5.2 mmol/L (odds ratio (OR) = 1.438, 95% confidence interval (CI) = 1.099–1.880, p = 0.008), and the degree of coronary artery lesions also became more severe (OR = 1.406, 95% CI = 1.107–1.788, p = 0.005). However, no such correlations were found in nondiabetic men. In conclusion, among the nondiabetic women in rural areas of northern Henan, both the incidence of CHD and the severity of lesions increased when FPG levels were greater than 5.2 mmol/L, while no significant correlation between FPG and CHD was observed in diabetes‐free men.
Forced Vibration in Cutting Process considering the Nonlinear Curvature and Inertia of a Rotating Composite Cutter Bar
Authors: Ren Yongsheng , Yao Donghui
Published: October 2020

Forced vibration of the cutting system with a three-dimensional composite cutter bar is investigated. The composite cutter bar is simplified as a rotating cantilever shaft which is subjected to a cutting force including regenerative delay effects and harmonic exciting items. The nonlinear curvature and inertia of the cutter bar are taken into account based on inextensible assumption. The effects of the moment of inertia, gyroscopic effect, and internal and external damping are also considered, but shear deformation is neglected. Equation of motion is derived based on Hamiltonʼs extended principle and discretized by the Galerkin method. The analytical solutions of the steady-state response of the cutting system are constructed by using the method of multiple scales. The response of the cutting system is studied for primary and superharmonic resonances. The effects of length-to-diameter ratio, damping ratio, cutting force coefficients, ply angle, rotating speed, and internal and external damping are investigated. The results show that nonlinear curvature and inertia imposed a significant effect on the dynamic behavior of the cutting process. The equivalent nonlinearity of the cutting system shows hard spring characteristics. Multiple solutions and jumping phenomenon of typical Duffing system are found in forced response curves.
Quantifying Liver‐Stomach Disharmony Pattern of Functional Dyspepsia Using Multidimensional Analysis Methods
Authors: Huang Zhongyu , Lyu Zipan , Hou Zhengkun , Wu Yuefeng , Huang Junqing , Liu Fengbin , Chen Jiaxu
Published: October 2020

Purpose. This study aims to develop and validate a quantitative model for measuring severity of a typical traditional Chinese medicine (TCM) pattern for functional dyspepsia (FD) using multidimensional analysis methods including confirmatory factor analysis (CFA) and multidimensional item response theory (MIRT). Methods. A scale and theoretical models were constructed according to the definition of pathogenesis about “liver‐stomach disharmony” patterns of FD. With data collected from 502 patients in a cross‐section study, the theoretical model was validated with CFA, and the related validity and reliability were evaluated in Amos 21.0. By the use of the MIRT paradigm, psychometric properties of the scale were estimated and evaluated for pattern quantification. Results. A scale consisting of 12 items was constructed detecting three latent traits of the pattern. The theoretical model was evaluated to be with adequate consistency with clinical data as RMSEA < 0.05, CFI = 0.94, and χ2/Df = 2.29. As the correlation between symptoms and related pattern factors evaluated to be with adequate factor loading, the instrument is of preliminary interpretation. Most precision of assessment could be achieved for patients with moderate severity of the pattern as shown in test information and standard error functions. Conclusions. An instrument with an interpretable conceptual framework was developed for pattern quantification in TCM clinical practice. By constructing and evaluating both psychological and physical effects in a multidimensional model of the TCM pattern of FD, the paradigm raised in this article provided a valuable reference for interpreting complex diseases and theories such as FD and TCM patterns.
Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF‐κB/NLRP3 Axis
Authors: Wang Tao , Gao Yanbin , Yue Rongchuan , Wang Xiaolei , Shi Yimin , Xu Jiayi , Wu Bingjie , Li Yimeng
Published: October 2020

Background. Podocyte injury plays an important role in diabetic nephropathy (DN). The aim of this study was to determine the potential therapeutic effects of the ginsenoside Rg1 on hyperlipidemia‐stressed podocytes and elucidate the underlying mechanisms. Methods. In vitro and in vivo models of DN were established as previously described, and the expression levels of relevant markers were analyzed by Western blotting, real‐time Polymerase Chain Reaction (PCR), immunofluorescence, and immunohistochemistry. Results. Ginsenoside Rg1 alleviated pyroptosis in podocytes cultured under hyperlipidemic conditions, as well as in the renal tissues of diabetic rats, and downregulated the mammalian target of rapamycin (mTOR)/NF‐κB pathway. In addition, Rg1 also inhibited hyperlipidemia‐induced NLRP3 inflammasome in the podocytes, which was abrogated by the mTOR activator L‐leucine (LEU). The antipyroptotic effects of Rg1 manifested as improved renal function in the DN rats. Conclusion. Ginsenoside Rg1 protects podocytes from hyperlipidemia‐induced damage by inhibiting pyroptosis through the mTOR/NF‐κB/NLRP3 axis, indicating a potential therapeutic function in DN.
Assessment of Quality of Life of Free Anterolateral Thigh Flap for Reconstruction of Tissue Defects of Total or Near-Total Glossectomy
Authors: Zhang Sanke , Wu Shuang , Liu Lei , Zhu Dandan , Zhu Qiuyu , Li Wenlu
Published: October 2020

Background. The aim of this study was to evaluate quality of life of free anterolateral thigh flap (ALTFF) for reconstruction of tissue defects of total or near-total glossectomy. Methods. Quality of life was assessed by means of the University of Washington Quality of Life (UW-QOL) and the 14-item Oral Health Impact Profile (OHIP-14), after 12 months postoperatively. Results. 65 of 79 questionnaires were returned (82.27%). In the UW-QOL, the best-scoring domain was “shoulder,” whereas the lowest scores were for “chewing” and “pain.” In the OHIP-14, the lowest-scoring domain was “handicap,” followed by “Social disability” and “Psychological disability.” Conclusion. Free anterolateral thigh perforator flaps for reconstruction of total or near-total glossectomy defects after cancer resection would have significantly influenced the patients’ oral functions and quality of life.
Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10
Authors: Shen Mengdie , Zhang Bibi , Wang Mengyao , Meng Li’na , Lv Bin
Published: October 2020

Aim. To explore the treatment effect of mica on 2,4,6-trinitrobenzenesulfonic acid solution- (TNBS-) induced colitis in mice. Materials and Methods. Thirty male BALB/C mice were randomly divided into the control group, the TNBS group, and the mica group. Control mice were treated with saline solution. Experimental colitis was induced by TNBS (250 mg/kg/d) in the TNBS group and the mica group. After modeling, the mica group was treated with mica (180 mg/kg/d) for 3 days, while the TNBS group continued the treatment with TNBS. All solutions were injected intrarectally. During treatment, body weight and mice activity were monitored daily. After treatment, the colon tissues of mice were collected; angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), angiotensin 1-7 (Ang (1-7)), IL-17A, and IL-10 expression was analyzed by ELISA and immunohistochemistry. Results. Food intake, activity, and body weight gradually decreased in the TNBS group compared to the control group and the mica group (all P<0.05). Also, black stool adhesion in the anus and thin and bloody stool were observed in the TNBS group, but not in the other two groups. Moreover, the expression of Ang II, ACE2, Ang (1-7), IL-17A, and IL-10 in the TNBS group increased compared to that in the control group. Compared to the TNBS group, ACE2, Ang (1-7), and IL-10 in the mica group increased, while Ang II and IL-17A decreased (all P<0.05). Conclusion. Mica can alleviate TNBS-induced colitis in mice by regulating the inflammation process; it reduces Ang II and IL-17A and increases ACE2, IL-10, and Ang (1-7).
Research on Anisotropic Characteristics of Rock and Intelligent Recognition of Precursory Signal
Authors: Li Nan , Zhang Zhibo , Khan Majid , Zhang Shaohua , Liu Xianan , Li Shujie
Published: October 2020

In order to study the change in anisotropic characteristics of rock materials during the uniaxial compression process, an advanced ultrasonic experimental device and loading device are used to establish an experimental system for measuring ultrasonic waveform in three orthogonal directions in real‐time. The experimental results show that there exists pronounced difference between ultrasonic receiving waveform in axial and radial directions. Based on the multifractal theory, multifractal spectrums of receiving waveform are calculated, and multifractal parameters (Δα and Δf) are further analyzed. The multifractal spectrum in the radial direction gradually becomes smaller, but the multifractal spectrum in the axial direction presents an “increase‐decrease” trend. During the entire uniaxial compression process, the anisotropic characteristics of the rock sample show an “enlarge‐reduce” trend, which is caused by the development and growth of microcracks. Furthermore, a quantitative relationship between multifractal parameter Δα and stress σ is proposed. It indicates that the parameters Δα and σ satisfy the power function. On this basis, a method is proposed that ultrasonic waveform precursor characteristics are recognized automatically using the backpropagation (BP) neural network to monitor the damage state of the rock sample. The application results show that this method can provide an early warning signal more than 100 seconds before the rock sample buckling failure. This research can provide a useful reference for studying the anisotropic characteristics of the rock sample during the uniaxial compression process. The proposed method in this paper has essential meaning for monitoring and early warning of rock stability.
A New Approach for Enhancing the Services of the 5G Mobile Network and IOT-Related Communication Devices Using Wavelet-OFDM and Its Applications in Healthcare
Authors: Raji Mordecai F. , Li JianPing , Haq Amin Ul , Ejianya Victor , Khan Jalaluddin , Khan Asif , Khalil Mudassir , Ali Amjad , khan Ghufran A. , Shahid Mohammad , Ahamad Bilal , Yadav Amit , Memon Imran
Published: October 2020

The heart of the current wireless communication systems (including 5G) is the Fourier transform-based orthogonal frequency division multiplex (OFDM). Over time, a lot of research has proposed the wavelet transform-based OFDM as a better replacement of Fourier in the physical layer solutions because of its performance and ability to support network-intensive applications such as the Internet of Things (IoT). In this paper, we weigh the wavelet transform performances against the future wireless application system requirements and propose guidelines and approaches for wavelet applications in 5G waveform design. This is followed by a detailed impact on healthcare. Using an image as the test data, a comprehensive performance comparison between Fourier transform and various wavelet transforms has been done considering the following 5G key performance indicators (KPIs): energy efficiency, modulation and demodulation complexity, reliability, latency, spectral efficiency, effect of transmission/reception under asynchronous transmission, and robustness to time-/frequency-selective channels. Finally, the guidelines for wavelet transform use are presented. The guidelines are sufficient to serve as approaches for tradeoffs and also as the guide for further developments.
Four Autophagy‐Related lncRNAs Predict the Prognosis of HCC through Coexpression and ceRNA Mechanism
Authors: Wu Hao , Liu Tiantian , Qi Jianni , Qin Chengyong , Zhu Qiang
Published: October 2020

Abnormally expressed long noncoding RNAs (lncRNAs) have been reported to affect the occurrence and progression of hepatocellular carcinoma (HCC) by modulating the autophagy axis. However, none of studies has explored the clinical significance of these autophagy‐related lncRNAs in HCC comprehensively. In this study, the RNA‐seq, miRNA‐seq, and clinical data of normal and HCC patients from the TCGA database and autophagy genes from the Human Autophagy Database were extracted. Subsequently, we screened out 78 differentially expressed autophagy‐related lncRNAs, and four prognostic‐related lncRNAs (LUCAT1, AC099850.3, ZFPM2‐AS1, and AC009005.1) were eventually used to develop the prognostic model. This signature could be regarded as an independent prognostic signature for HCC patients and has the highest prediction efficiency than other clinicopathological factors for the 1‐, 3‐, and 5‐year survival (AUC = 0.764, 0.738, and 0.717, respectively). Additionally, regardless of whether the clinical information is complete for HCC patients, the autophagy‐related lncRNA model shows a good predictive power for the overall survival. Importantly, the coexpression network of 4 lncRNAs and 11 autophagy‐related genes was constructed. Moreover, based on the bioinformatic analyses, our results found that LUCAT1 and ZFPM2‐AS1 may affect the autophagic activity in HCC through the hsa‐miR‐495‐3p/DLC1 and hsa‐miR‐515‐5p/DAPK2 axis, respectively. In conclusion, we establish an effective prognostic model for HCC patients and shed new light on the autophagy‐related regulatory mechanisms of the identified lncRNAs.