bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of cabozantinib in metastatic renal cell carcinoma patients: Russian multicenter observational study
Authors: Volkova M. I. , Kalpinskiy A. S. , Men'shikov K. V. , Gorbuleva L. V. , Evsyukova O. I. , Meltonyan V. R. , Mishugin S. V. , Maturov M. R. , Ol'shanskaya A. S. , Shemetov D. Yu. , Sannikova T. A. , Makhnutina M. V. , Filip'eva M. A. , Gaysina E. A. , Ovchinnikova E. G. , Matveev V. B. , Alekseev B. Ya.
Published: May 2023

Purpose: an assessment of efficacy and safety of cabozantinib in unselected patients with metastatic renal cell carcinoma in the first and subsequent lines of therapy.

Materials and methods. Russian multicenter observational study included 92 consecutive patients with morphologically verified metastatic renal cell carcinoma treated with cabozantinib (60 mg/d) in 16 Russian centers. Median age of the patients was 56 (19-79) years, a male-to-female ratio - 3:1. At the start of cabozantinib therapy 27.2 % of patients had ECOG PS 2. Most common histological type of kidney cancer was clear-cell RCC (90.2 %). Most patients were diagnosed with synchronous (71.7 %) multiple metastases (60.9 %). Previous nephrectomy was performed in 87.0 % of cases. Prognosis according to International Metastatic Renal Cancer Database Consortium (IMDC) score was assessed as favorable in 5.4 %, intermediate - in 58.7 % and poor - in 35.9 % patients. Cabozantinib as the first-line therapy was administered in 9 (9.8 %), following 1-5 lines of systemic treatment - in 83 (90.2 %) cases. Median follow-up was 11 (2.3-44.5) months.

Results. In patients, receiving cabozantinib as the first-line therapy, objective response rate was 66.7 %, tumor control was reached in 100 % of cases. Median time to the objective response was 2.6 (1.9-3.6) months, median objective response duration - 13.2 (6.2-21.5) months. Median progression-free survival (PFS) and overall survival (OS) were not reached, 6- and 12-months PFS was 77.8 % and 77.8 %, 6- and 12-months OS - 88.9 % and 88.9 % respectively. Cabozantinib as the second and subsequent lines of therapy provided objective response rate of 34.9 %, tumor control rate - 97.6     %. Median time to the objective response was 2.5 (1.8-4.1) months, median objective response duration - 12.6 (5.5-27.3) months. Median PFS was not reached (6- and 12-months PFS - 92.5 % and 73.1 % respectively), median OS was 32.6      months (6- and 12-months OS - 97.4 % and 80.8 % respectively). Any adverse events (AE) developed in 88.8 %, AE grade III-IV - in 32.6 % of cases. Most frequent AE grade III-IV included arterial hypertension (18.5 %), diarrhea (6.5 %) and palmar-plantar erythrodysesthesia (6.5 %). Unacceptable toxicity demanded treatment cancellation in 2.2 %, therapy interruption - in 16.3 % and dose reduction - in 30.4 % of patients.

Conclusion. Cabozantinib as the first and subsequent lines of therapy for metastatic renal cell carcinoma patients in the real world practice demonstrated high efficacy and better tolerability comparing with population assigned for cabozantinib monotherapy in the randomized phase II-III trials.
Classification urine leakage from urethrovesical anastomosis after prostatectomy
Authors: Petrosyan G. S. , Keln A. A.
Published: May 2023

Background. Urine leakage from urethrovesical anastomosis (UVA) is a frequent and significant complication after prostatectomy.

Aim. To determine frequency urine leakage from the anastomosis after prostatectomy, evaluate diagnostic methods, develop classification and management guidelines for patients with this complication.

Materials and methods. A retrospective analysis of 1426 patients who underwent prostatectomy was performed. Results. In total, 97 (6.8 %) patients developed UVA failure in the early postoperative period. The complication was diagnosed on the 7th day after prostatectomy using retrograde cystography. An original classification urine leakage from the anastomosis after prostatectomy was proposed using numbers (0, I, II, III) and letters (A, B, C). In 50 (3.4 %) patients, grade I (A, B, C) UVA failure was diagnosed; 38 (2.7 %) patients had grade II (A, B, C) UVA failure; 9 (0.6 %) patients had grade III (A, B) UVA failure. The developed classification allows to accurately determine the severity of UVA failure and apply the appropriate methods for its correction.

Conclusion. Urine leakage from UVA is a serious problem in surgical treatment of prostate cancer. Currently, it is necessary to systematize the available data and introduce unified classification and algorithm for correcting this complication into clinical practice.
Combined radiotherapy and hormone therapy in unfavorable intermediate risk prostate cancer
Authors: Makarova K. S. , Gumenetskaya Yu. V. , Biryukov V. A. , Rodina T. A. , Galitsyna A. B. , Shchukina E. O. , Karyakin O. B. , Ivanov S. A. , Kaprin A. D.
Published: May 2023

Background. Currently, the group of intermediate risk prostate cancer (PC) includes 2 subgroups - favorable and unfavorable intermediate risk according to the National Comprehensive Cancer Network (NCCN) classification. The optimal scope of therapy is not defined for the unfavorable intermediate risk subgroup. In particular, the need for and duration of hormone therapy (HT) during combined radiotherapy (CRT) have not yet been determined.

Aim. To perform a comparative analysis of the efficacy and toxicity of CRT in patients with unfavorable intermediate risk treated with and without HT.

Materials and methods. Eighty-four (84) patients with unfavorable intermediate risk PC were treated with CRT at the clinic of the A.F. Tsyb Medical Radiological Research Center between May 2016 and December 2020. Patients were divided into two groups: external beam radiation therapy + brachytherapy (n = 40) and external beam radiation therapy + brachytherapy + HT (n = 44). Conformal external beam radiation therapy was delivered with conventional fractionation to a total dose of 44-46 Gy and the 192Ir high-dose rate brachytherapy was delivered with a single fraction of 15 Gy. Median duration of HT consisting of gonadotropin-releasing hormone agonist was 6 months. Median age was 65.2 years (range: 49-80 years). Median follow-up was 58.1 months (range: 18.6-83.7 months).

Results. With a median follow-up of 4.8 years, progression-free survival was 95 % and 97.6 % in the external beam radiation therapy + brachytherapy group and external beam radiation therapy + brachytherapy + HT group, respectively (p = 0.578). The break between treatment stages of more than 28 days was associated with a statistically significant increase in the risk of PC recurrence (p = 0.007). Overall survival for the external beam radiation therapy + brachytherapy group versus external beam radiation therapy + brachytherapy + HT group was 97.5 and 93.2 % (p = 0.376), respectively.

Late genitourinary toxicity was grade I in 8 (9.5 %) patients and grade II in 1 (1.2 %) patient. Urethral stricture developed in 3 (3.6 %) patients. Late gastrointestinal toxicity was grade I in 7 (8.3 %) patients and grade II in 1 (1.2 %) patient. There were no statistically significant differences in the incidence of late complications between groups with and without HT. There was a statistically significant (p = 0.049) effect of prostate volume on the incidence of late radiation proctitis.

Conclusion. There were no statistically significant differences in progression-free survival and overall survival in patients with unfavorable intermediate risk PC who received external beam radiation therapy + brachytherapy with or without HT. The incidence and severity of adverse events were acceptable and allowed patients with PC to maintain high quality of life.
A rare complication after endoscopic neurolysis of the sciatic nerve: а clinical case
Authors: Belyak Evgeniy A. , Paskhin Dmitry L. , Lazko Fedor L. , Prizov Alexey P. , Asratyan Sarkis A. , Zagorodniy Nikolay V.
Published: May 2023

Background: Еndoscopic neurolysis of the sciatic nerve has proven itself as a low traumatic and effective technique of treatment for deep gluteal pain syndrome and sciatic nerve neuropathy. Until now, there have been no publications dedicated to the parietal peritoneum damage after endoscopic sciatic nerve decompression.
Clinical case description: A 70-year-old female patient with deep gluteal pain syndrome and sciatic nerve neuropathy on the right side and failure of a conservative treatment. According to the VAS scale, the severity of pain syndrome was 10 cm. The severity of the motor dysfunction, according to the BMRC scale, was 4 points. The severity of the sensitive dysfunction, according to the Seddon scale, was 3 points. The functional activity of the lower limb, according to the LEFS scale, was 48 points. The instrumental investigation of the sciatic nerve included MRI, ultrasound, and ENMG. Endoscopic sciatic nerve decompression was performed in the prone position with saline irrigation using the technique published before. After the surgery, an ultrasound study and a CT scan were performed, which determined the presence of a free fluid in the abdominal cavity, and edema of the right retroperitoneal space. The patient underwent laparoscopy, which revealed the area of the parietal peritoneum damage in the lower floor, with a free saline fluid detected in the abdominal cavity, which was evacuated. The patient was discharged from the hospital on the 10th day after the surgery. 6 months after the surgery, the functional activity of the lower extremity, according to the LEFS scale, was 52 points. Pain syndrome, according to the VAS scale, was 8 cm. The severity of the motor dysfunction, according to the BMRC scale, was 4 points. The severity of the sensitive dysfunction, according to the Seddon scale, was 3 points. The performed surgical endoscopic treatment was rendered ineffective.
Conclusion: The method of endoscopic sciatic nerve decompression with saline pumping has a risk of the following complication: damaging the parietal peritoneum, saline penetration into the abdominal cavity, edema of the retroperitoneal space. To decrease the risk of this complication, it is necessary to observe the specific surgical conditions such as: controlled hypotension in a patient and a low pressure in the arthroscopic pump, the time of surgery not exceeding 1 hour, and the saline consumption not exceeding 10 liters. It is also crucial not to perform the dissection and neurolysis too proximal to the piriformis area.
A clinical case of drug-induced arterial hypertension caused by glycyrrhizic acid
Authors: Antropova Oxana N. , Osipova Irina V. , Silkina Svetlana B. , Obrazcova Lolita A.
Published: May 2023

Background: In clinical practice, drug-induced arterial hypertension (AH) often remains undiagnosed, since the identification of an ethical disease in this form of AH avoids the initiation of antihypertensive therapy. A critical part in the differential diagnosis of hypertension and planning of long-term strategies for managing a patient requires a thorough study of the properties of the drugs taken and the pathophysiological mechanisms that depend on the increase in high blood pressure against the background of taking one or another substance.
Clinical case description: Assumption of pregnancy in a random 57-year-old Caucasian female patient with AH syndrome and history of AD crisis during the year. Against the background of two-component antihypertensive therapy, indapamide 2.5 mg + telmisartan 80 mg, increased blood pressure. From the anamnesis of life, it is noteworthy that the patient should keep records with a hepatologist; with a diagnosis of chronic viral hepatitis C with moderate activity, she takes Phosphogliv. Physical examination confirmed the presence of grade 2 hypertension; no signs of target organ detection were found. Laboratory and instrumental research showed cytolytic syndrome of minimal activity (AST, 74.8 U/l; ALT, 60.5 U/l), hypokalemia (K+ 2.1 mmol/l), unknown etiology, aldosterone within the normal range, metanephrine (80.4 pg/ml at a rate of 64 pg/ml), and normetanephrine (276 pg/ml at a rate of 176 pg/ml) in blood plasma are increased. MSCT of the kidneys and adrenal glands revealed no enlarged formations. Drug-induced arterial hypertension was clinically diagnosed. Concomitant diseases: Chronic viral hepatitis C, moderate activity. Varicose veins, venous infection of the extremities. Dynamics and outcome. After the abolition of glycyrrhizic acid, blood pressure and potassium levels in the blood plasma returned to normal, which is not recommended to take antihypertensive drugs.
Conclusion: An exceptional clinical situation is a pronounced manifestation of a rare side effect of glycyrrhizic acid in the form of drug-induced hypertension.
Semielemental mixtures and their role in the nutrition of operated children
Authors: Erpuleva Julia V.
Published: May 2023

The lecture is intended for professionals dealing with issues of enteral nutrition in children. The lecture discusses the main indications for the use of mixtures based on hydrolyzed protein.
The features of the gastrointestinal tract of young children are described, the advantages of using whey protein are noted.
The choice of enteral formula in patients in the acute period of critical ill with brain damage in the neurocritical care unit
Authors: Krylov Kirill Yu. , Sviridov Sergey V. , Vedenina Irina V. , Yagubyan Ruben S.
Published: May 2023

Nutritional support is an important and integral part of the treatment process for critically ill patients. Patients after neurosurgical interventions and patients with damage to the central nervous system, for example, due to acute ischemic stroke, may be due to the severity of the condition in the intensive care unit. This is a separate category of patients and nutritional support for this category of patients has its own characteristics. Enteral nutrition, as the most physiological type of nutrition, should be an integral part of the treatment process in the intensive care unit. In patients in the acute period of a severe condition with brain damage, in addition to the metabolic response to damage, there are also factors that limit the implementation of enteral nutrition: the brain damage itself, being in intensive care, and methods of intensive therapy. The choice of an enteral formula in this category of patients is complex and fundamental to provide adequate nutritional support to cover energy and protein requirements. The purpose of this scientific review is to highlight the issues of choosing a mixture for enteral nutrition of patients in the neurocritical care unit who are in the acute period of a critical ill.
Antibacterial microcins, class II: A review
Authors: Blinkova Larisa P. , Altshuler Mike L. , Mironov Andrey Yu.
Published: May 2023

In medicine, the issue of the use of effective antibacterial substances against drug-resistant microorganisms remains relevant. Most publications on microcins show undoubted prospects for the further development of these pharmacological agents of bacterial origin with multidirectional action (antibacterial, antiviral, antitumor, etc.). One of the features of microcins is their specific inhibitory activity against gram-negative microorganisms (Escherichia, Proteus, Salmonella, Pseudomonas, etc.). This review aimed to briefly summarize current information about one of the groups of microcins (class II) to assess their possible use in practical medicine and scientific research. The review uses sources from the Russian Science Citation Index, Web of Science, Scopus, and PubMed databases.
Evaluation and Creation of Web-based Resource Guides using SubjectsPlus
Authors: Manu T. R. , Hasan Nabi
Published: May 2023

The Resource Guide is a unified platform curated and administered by subject specialists, librarians, and liaisons, offering users access to a wide array of resources. Traditionally known by various names such as Pathfinder, bibliography, virtual reference collection, online guide, online tutorial, toolkit, or web guide, it serves as a comprehensive tool. Its primary purpose is to assist users in locating resources specific to their subject areas, staying updated on new resources, and connecting them to relevant, easily understandable information. At Central Library, IIT Delhi, diverse platforms like the library website, social media, online catalogues, Pathfinder, single search engine, and mobile app are utilized to promote library resources. However, these platforms may lack subject-level resources. This raises the question of designing and developing an online platform or resource base that consolidates and enables users to access various resources, including print resources, e-resources, professional development resources, open-access resources, and social media resources. This endeavour aims to meet the present and future needs of users in their respective disciplines. To explore this concept further, a pilot implementation of a web-based resource guide has been initiated at Central Library, IIT Delhi. This paper investigates how SubjectsPlus, an open-source tool, can facilitate the creation and management of web-based resource guides that promote the use of library and scholarly resources on the web.
Enhancing OPAC through Geospatial Data: Stackmaps and Text Visualization in Koha
Authors: Kerketta Soumik , Mukhopadhyay Mondrita
Published: May 2023

Physical stacks in academic libraries, despite the advent of digital repositories, remain important to users, especially in countries like India where physical resources hold considerable value. This study seeks to develop a system that enables users to locate books physically by integrating stackmaps functionalities with Koha OPAC. In addition, the study showcases how an open-source text analytics server can be incorporated inside an OPAC in Koha to generate various word-level visualizations by analyzing a text corpus, including the identification of geospatial features such as place names. This research aims to contribute to the advancement of information retrieval and visualization techniques in OPACs in academic libraries, and to improve the user experience in locating physical resources. (The video abstract of this paper may be found at: https://youtu.be/q940TUkcTTE ).
Implementation of Koha in managing the e-resources of the library
Authors: Garg Mohit , Hasan Nabi , Gupta Amit
Published: May 2023

In the digital era, libraries have been acquiring and subscribing to various types of digital resources. Each e-resource possesses distinct formats and search requirements, offers multiple access and authentication methods, and involves complex licensing agreements. Therefore, effectively managing these diverse e-resources necessitates a system that simplifies the processes of acquisition, access, and organization. An Electronic Resource Management System (ERMS) presents a potential solution for centralizing these operations. Numerous open source and commercial ERMS solutions are available and utilized in libraries worldwide. Nevertheless, numerous studies have revealed that libraries face financial constraints as well as limitations in terms of ICT infrastructure. An ideal solution should be both cost-effective and require minimal ICT infrastructure. Koha is one such software that has gained popularity in library automation, making it a viable option for managing e-resources. This study explores the implementation of Koha, version 22.11, for managing a library's e-resources. The study aims to investigate the existing features and functionalities of Koha in the context of libraries.
A Note from the Editor
Authors: Raghavan K. S.
Published: May 2023

No Abstract.
Kajian Dampak Lingkungan Terhadap Kegiatan Rekonstruksi Sarana dan Prasarana Pasar Tugu Kota Depok
Authors: Alimuddin Alimuddin , Chayati Nurul , Rulhendri Rulhendri , Fitri Ria
Published: May 2023

Abstrak. Dinas Perumahan dan Permukiman, Kota Depok berencana melakukan rekonstruksi bangunan Pasar Tugu untuk meningkatkan sarana dan prasarana dibidang perekonomian. Kegiatan tersebut akan memiliki dampak lingkungan dan sosial bagi masyarakat sehingga diperlukan kajian dampak lingkungan. Tujuan dari penelitian ini adalah untuk mengetahui kondisi lingkungan rona awal di lokasi penelitian dan untuk mendapatkan hasil analisis kajian dampak lingkungan dan cara penanggulangan dalam meminimalisasi dampak yang terjadi pada saat tahap pra konstruksi, tahap konstruksi, dan tahap operasi. Metode yang digunakan dalam penelitian ini adalah metode survei. Hasil dari penelitian ini adalah kondisi rona awal lingkungan pada lokasi penelitian menunjukkan bahwa kualitas lingkungan di lokasi penelitian dalam kategori baik, baik dari segi komponen kualitas udara ambien dan kebisingan maupun komponen kualitas air tanah dan pada setiap kegiatan mulai dari tahap pra konstruksi, konstruksi, hingga tahap operasi, masing-masing tahap memiliki dampak positif dan dampak negatif terhadap lingkungan. Dampak negatif yang terjadi dapat diminimalkan dengan melakukan pengelolaan lingkungan yang baik pada setiap tahapan kegiatan dimulai dari tahap pra konstruksi hingga tahap operasi agar terciptanya suatu konstruksi yang ramah lingkungan.Environmental Impact Assessment on the Reconstruction of Facilities and Infrastructure for Pasar Tugu, Depok CityAbstract. Department of Housing and Settlements, Depok City plans to reconstruct the Pasar Tugu building, Depok City to improve facilities and infrastructure in the economic sector. These activities will have environmental and social impacts on the community so an environmental impact study is needed. The purpose of this study is to know the environmental baseline conditions at the research location and to obtain the results of environmental impact analysis and countermeasures in minimizing the impacts that occur during the pre-construction, construction, and operation stages. The method used in this research is a survey method. The results of this study are the environmental baseline conditions at the research location indicate that the environmental quality at the research location is in a good category in terms of the ambient air quality and noise components and groundwater quality components and in every activity starting from the pre-construction stage, construction, to the operation stage, each stage has a positive impact and a negative impact on the environment. The negative impacts that occur can reduce good environmental management at every stage of the activity starting from the construction stage to the operation stage in order to make an environmentally friendly construction.
Analisis Indeks Kekeringan Hidrologi DAS Krueng Aceh (Studi Kasus Sub DAS Krueng Jreue dan Sub DAS Krueng Khee)
Authors: Aldin Attabari , Basri Hairul , Syahrul Syahrul
Published: May 2023

Abstrak.  Luas Sub DAS Krueng Jreue 23.218,06 Ha dan Sub DAS Krueng Khee 9.599,66 Ha. Berdasarkan hasil kajian bahwa luas vegetasi tutupan lahan semakin berkurang setiap tahunnya dimana ditandai dengan tingginya nilai fluktuasi debit sehingga mengakibatkan banjir pada musim hujan dan kekeringan pada musim kemarau. Tujuan penelitian adalah untuk mengetahui nilai ambang batas kekeringan hidrologi di Sub DAS Krueng Jreue dan Sub DAS Krueng Khee dan indeks kekeringan hidrologi di Sub DAS Krueng Jreue dan Sub DAS Krueng Khee. Penelitian ini menggunakan metode ranking Weibull dimana ditentukan nilai ambang batas Q50 dan Q80, dihitung defisit dan durasi dan kemudian ditentukan nilai indeks kekeringan hidrologi. Nilai ambang batas Sub DAS Krueng Jreue adalah 0,067 m3/s dan Sub DAS Krueng Khee 0,181 m3/s. Defisit Sub DAS Krueng Jreue tahun 2014 adalah tertinggi dengan angka 0,401 m3/s dengan durasi kering tujuh bulan dan Sub DAS Krueng Khee tahun 2012 adalah tertinggi dengan angka -0,715 m3/s dengan durasi kering enam bulan. Indeks kekeringan hidrologi di Sub DAS Krueng Jreue tahun 2015 adalah tertinggi dengan nilai 0,0629 m3/s dan indeks kekeringan hidrologi di sub DAS Krueng Khee tahun 2011 adalah tertinggi dengan nilai 0,3282 m3/s.An Analysis of The Krueng Aceh’s Hydrological Drought Index  (A Case Study of The Sub Watershed Krueng Jreue and Krueng Khee)Abstract.  The area of the Krueng Jreue Sub-watershed is 23,218.06 Ha and the Krueng Khee Sub-watershed is 9,599.66 Ha. Based on the results of the study that the area of land cover vegetation decreases every year which is indicated by the high value of discharge fluctuations, resulting in flooding in the rainy season and drought in the dry season. The purpose of this study was to determine the threshold value for hydrological drought in the Krueng Jreue Sub-watershed and Krueng Khee Sub-watersheds and the hydrological drought index in the Krueng Jreue Sub-watershed and Krueng Khee Sub-watersheds. This study uses the Weibull ranking method where the threshold values for Q50 and Q80 are determined, the deficit and duration are calculated and then the hydrological drought index value is determined. The threshold value for the Krueng Jreue Sub-watershed is 0.067 m3/s and the Krueng Khee Sub-watershed is 0.181 m3/s. The Krueng Jreue Sub-watershed deficit in 2014 was the highest at 0.401 m3/s with a dry duration of seven months and the Krueng Khee Sub-watershed in 2012 was the highest at -0.715 m3/s with a dry duration of six months. The hydrological drought index in the Krueng Jreue Sub-watershed in 2015 was the highest with a value of 0.0629 m3/s and the hydrological drought index in the Krueng Khee Sub-watershed in 2011 was the highest with a value of 0.3282 m3/s.
The study of shelf-life of soymilk treated by pasteurization methods by using organoleptic test
Authors: Hariono Budi , Kautsar Syamsiar , Brilliantina Aulia , Kurnianto Mokhamad Fatoni , Wijaya Rizza
Published: May 2023

AbstractSoymilk is generally processed by a pasteurization process. Pasteurization itself is a method that is widely known in the processing industry as a method to kill microorganisms using high temperatures or commonly referred to as thermal methods that result in damage to physical and chemical components. Therefore, a non-thermal pasteurization process such as high pulsed electric field (HPEF) is needed to maintain product quality attributes. The purpose of this study is to determine the shelf life of soymilk treated by using organoleptic test. About 20 panellists evaluated the quality of soymilk based on color and flavour. Results showed that the HPEF treatment did not change the color and aroma of soybean juice products for 11 hours. It can extend the shelf life of soybean juice for 1 hour compared to the thermal pasteurization process.AbstrakSusu kedelai pada umumnya diolah dengan proses pasteurisasi. Pasteurisasi sendiri merupakan sebuah metode yang banyak dikenal dalam industri pengolahan sebagai metode untuk membunuh mikroorganisme menggunakan suhu tinggi atau biasa disebut dengan metode termal yang  mengakibatkan kerusakan komponen fisik serta kimiawi. Oleh karena itu, dibutuhkan proses pasteurisasi non-termal seperti high pulsed electric field (HPEF) yang dapat menjaga atribut mutu produk. Adapun tujuan dari penelitian ini adalah mengkaji umur simpan susu kedelai yang diberi perlakuan metode pasteurisasi dengan uji organoleptik. Sebanyak 20 orang panelis memberikan penilaian terhadap sampel susu secara deskriptif berdasarkan kriteria warna dan aroma. Hasil penelitian menunjukkan bahwa perlakuan HPEF tidak merubah warna dan aroma dari susu kedelai sampai 11 jam. Hal ini menunjukkan bahwa metode HPEF dapat memperpanjang umur simpan susu kedelai selama 1 jam dibandingan metode pasteurisasi termal.
Deep Learning Paradigms for Existing and Imminent Lung Diseases Detection: A Review
Authors: Vohra Bhavna , Mittal Sumit
Published: May 2023

Diagnosis of lung diseases like asthma, chronic obstructive pulmonary disease, tuberculosis, cancer, etc., by clinicians rely on images taken through various means like X-ray and MRI. Deep Learning (DL) paradigm has magnified growth in the medical image field in current years. With the advancement of DL, lung diseases in medical images can be efficiently identified and classified. For example, DL can detect lung cancer with an accuracy of 99.49% in supervised models and 95.3% in unsupervised models. The deep learning models can extract unattended features that can be effortlessly combined into the DL network architecture for better medical image examination of one or two lung diseases. In this review article, effective techniques are reviewed under the elementary DL models, viz. supervised, semi-supervised, and unsupervised Learning to represent the growth of DL in lung disease detection with lesser human intervention. Recent techniques are added to understand the paradigm shift and future research prospects. All three techniques used Computed Tomography (C.T.) images datasets till 2019, but after the pandemic period, chest radiographs (X-rays) datasets are more commonly used. X-rays help in the economically early detection of lung diseases that will save lives by providing early treatment. Each DL model focuses on identifying a few features of lung diseases. Researchers can explore the DL to automate the detection of more lung diseases through a standard system using datasets of X-ray images. Unsupervised DL has been extended from detection to prediction of lung diseases, which is a critical milestone to seek out the odds of lung sickness before it happens. Researchers can work on more prediction models identifying the severity stages of multiple lung diseases to reduce mortality rates and the associated cost. The review article aims to help researchers explore Deep Learning systems that can efficiently identify and predict lung diseases at enhanced accuracy.
Effect of AM fungi during salt stress on biochemical content in Ginger (Zingiber officinale Rosc.)
Authors: Bhosale Kishor , Shinde Bharat
Published: May 2023

Ginger (Zingiber officinale Rosc.) is a highly-grown spice crop; its aromatic rhizomes are commercially important due to its high importance in the diet as a spice and some medicinal values. Irrigation methods in India increase salt content in the soil. Arbuscular Mycorrhizal (AM) fungi assist plants under salt stress. However, the vital role of mycorrhizal fungi in ginger salt tolerance has not been evaluated yet and needs to emphasize on its evaluation. The present investigation was conducted to assess the efficacy of AM fungi on ginger plants grown under different salt concentrations. In the current investigation level of Chlorophyll, nucleic acids like DNA and RNA, Proteins, Proline, reducing sugars, and total soluble carbohydrates contents have been evaluated to estimate the Growth and biochemical parameters. The study revealed that AM fungi significantly contributed to the salt stress tolerance of Ginger plants. Statistical analysis found an enormously significant correlation between growth parameters and salt tolerance. Pearson correlation coefficient has been used as testimony, resulting in a positive correlation of the use of AM fungi on ginger plant's Growth and biochemical contents.
Isolation and production of polyhydroxybutyrate (PHB) from Bacillus pumilus NMG5 strain for bioplastic production and treatment of wastewater from paper factories
Authors: Minh Ho Ky Quang , Thai Ngo Duy , Khoa Tran Vu Anh , Ngoc Thao Nguyen Thi , Sichaem Jirapast
Published: May 2023

Polyhydroxybutyrate (PHB) has the potential to replace traditional plastics and limit environmental pollution caused by plastic waste. This study combined wastewater treatment with PHB production to reduce costs. Bacteria capable of synthesizing PHB were isolated from paper mill wastewater and identified using Matrix Assisted Laser Desorption/Ionization–Time of Flight (MALDI-TOF) mass spectrometry and 16S rRNA gene analysis. Bacillus pumilus NMG5 strain was found to have a good yield in modified Nutrient Broth culture, reaching 42.28% of dry biomass. The PHB product was analyzed using FTIR spectroscopy and 1H NMR spectroscopy. The bacterial strain was also tested for its ability to treat paper mill wastewater, and it showed impressive results in terms of biochemical oxygen demand (COD), total nitrogen, and total phosphorus, with efficiencies of 95.93%, 79.36%, and 83.55%, respectively. The study found that wastewater treatment combined with PHB production was a promising solution to reduce costs and limit environmental pollution. The bacterial strain B. pumilus NMG5 had a high yield of PHB, and the PHB product was of high quality, as confirmed by FTIR and 1H NMR spectroscopy. Furthermore, the bacterial strain showed impressive results in treating paper mill wastewater with high COD, total nitrogen, and total phosphorus efficiencies. These results suggest that this harmless bacterium could be used in paper mill wastewater treatment systems to produce PHB, providing a sustainable and environmentally friendly solution.
Phytochemical investigations, in-vitro antioxidant, antimicrobial potential, and in-silico computational docking analysis of Euphorbia milii Des Moul
Authors: Ahmed Md Sohel , Khan Israt Jahan , Aman Shahbaz , Chauhan Samrat , Kaur Narinder , Shriwastav Shalini , Goel Kirti , Saini Monika , Dhankar Sanchit , Singh Thakur Gurjeet , Dev Jai , Mujwar Somdutt
Published: May 2023

Euphorbia milii Des Moul is a deciduous bush indigenous to Madagascar. The present study aims to investigate the presence of the phytochemical, in-vitro antioxidant and antimicrobial potency, and in-silico computational analysis of ethanolic and aqueous preparations of E. milii leaves and flowers. The ethanolic and aqueous extracts were tested for in-vitro antioxidant activity by DPPH, H2O2, TAC, and FRAP assay. In addition, antimicrobial potentials were assayed by agar well diffusion technique against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Candida albicans for various clinical isolates. The qualitative phytochemical analysis results confirmed the existence of alkaloids, flavonoids, phenolics, and tannins. The quantitative analysis elicits the availability of a magnificent number of alkaloids, flavonoids, phenolics, flavonols, and tannins. Among all the extracts, aqueous extracts of leaves exhibited potent antioxidant activity in DPPH, FRAP, and H2O2 assay with the IC50 value of 30.70, 60.05, and 82.92µg/mL, respectively. In agar well diffusion assay, all extracts displayed zone of inhibition varies from 2-24mm at different concentrations ranging from 10-320 mg/mL, whereas no activity was observed against Candida albicans. Furthermore, docking-based computational analysis has revealed that beta-sitosterol and taraxerol are the plant's active constituents responsible for their antimicrobial and antioxidant activities. Research findings suggest that the E. milii plant has an excellent prospect for further study for its extended antioxidative and antimicrobial potential. It could be a natural source of various ailments and can be utilized to develop new drugs.
Taxonomic Evaluations of the Achene Fatty Acid Composition of Three Morphologically Similar Tripleurospermum (Asteraceae) Species
Authors: İNCEER Hüseyin , AYAZ Faik
Published: May 2023

Tripleurospermum tempskyanum, T. disciforme and T. decipiens (Asteraceae) are species with similar morphological characteristics that can therefore be easily confused with one another. In this study, achene fatty acid content of T. tempskyanum and T. disciforme from Türkiye was analysed using gas chromatography (GC) for the first time. The fatty acid data for these species together with the fatty acid data in the literature of T. decipiens were evaluated in terms of taxonomy using cluster analysis and principal components analysis. Eleven fatty acids were determined in the achenes of T. tempskyanum and T. disciforme. Additionally, linoleic acid (C18:2n6c), palmitic acid (C16) and α-linolenic acid (C18:3n3c) were detected as major fatty acids. The results of cluster analysis and principal components analysis indicated that achene fatty acids may be used as a chemotaxonomic marker to support the morphological separation of these species.
Investigation of Antimicrobial Activities and 16S rRNA Sequences of Actinomycetes Isolated from Karst Caves in the Eastern Black Sea Region of Türkiye
Authors: TÜFEKCİ Enis Fuat , UZUN Ümit , SAĞLAM ERTUNGA Nagihan , BİBER Ayşenur , HIDIROĞLU İnanç Alptuğ , TEKKILIÇ İlayda , ALTAY Birhan , KILIÇ Ali Osman
Published: May 2023

Considering that most antibiotics originate from actinomycete group bacteria, especially the Streptomyces genus, it is predicted that novel actinomycetes isolated from extreme environments such as caves may bring novel antibiotics to the medical world. The study aimed to screen the antimicrobial activity of actinomycetes isolated from the three karst caves in Türkiye and to identify selected isolates with antimicrobial activity by molecular methods. One hundred seventy-nine actinomycetes isolated from Akçakale, Kırklar (Altıntaş), and Köprübaşı Caves in Gümüşhane province in the Eastern Black Sea Region of Türkiye were included in the study. The antimicrobial activity of isolates was investigated using the modified cross-streak agar method against seven Gram-negative bacteria, three Gram-positive bacteria, and one yeast strain. Fifty-three isolates (29.6%) had antimicrobial activity against at least one of the tested microorganisms. The rate of isolates exhibiting antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Chromobacterium violaceum, Klebsiella pneumoniae, Salmonella Typhimurium, Escherichia coli, Acinetobacter haemolyticus, Pseudomonas aeruginosa, Enterobacter aerogenes, and Candida albicans was 21.2%, 20.0%, 16.8%, 12.8%, 3.4%, 2.8%, 2.2%, 1.1%, 0.6%, 0.6%, and 0.6%, respectively. An actinomycete isolate, TRMS 124, showed antimicrobial activity against ten test microorganisms. The 16S ribosomal RNA (16S rRNA) sequencing was performed for the identification and phylogenetic analysis of 26 isolates randomly selected among actinomycetes that exhibited antimicrobial activity against at least three test microorganisms. As a result, it was determined that 24 isolates showed homology with various Streptomyces species and two isolates with Embleya scabrispora and Couchioplanes caeruleus, respectively. These results showed that karst caves could be good sources for isolating actinomycetes with the potential to produce antimicrobial compounds.
Market Segmentation, Targeting, and Positioning Using Machine Learning
Authors: Paruchuri Harish
Published: May 2023

The occurrence of numerous rivals and industrialists has created a lot of pressure between rivalry companies to go in search of new customers and at the same time working to maintain the existing ones. Owing to this, the necessity for a new customer service policy or strategy becomes essential irrespective of the business size. Moreover, the capability of any company that wants to remain in existence and growth as well needs to understand its clients and also delivers necessary customer support to make available targeted client services and develop branded clients’ service policy. This understanding is conceivable via organized client service. The respective segment devises consumers who share similar market potentials. Big data philosophies and machine learning devise appropriate means of promoting better recognition and approval of computerized client segmentation methods in good turn of outdated business analytics that frequently lead to any meaningful approach that can keep or source for a new customer while the client disreputable is very growing by the day. This study makes use of the k-means clustering algorithm for this determination. The Sklearn public library was established for the k-Means algorithm and the package is competent by means of a 100-model two-parameters dataset generated or collected from the retail trade. Features of an average figure of client buying and average figure of periodic consumers.
Investigating the Prospects of Generative Artificial Intelligence
Authors: Mandapuram Mounika , Thodupunori Swetha Reddy , Bodepudi Anusha , Reddy Manjunath
Published: May 2023

In this exploratory work, we investigate cutting-edge techniques in machine learning known as Generative Artificial Intelligence (GenAI). The costs of trial and error during product development can be significantly reduced if faster, more affordable, and more accurate multi-scale materials simulations powered by fully generative artificial intelligence are available. Engineers have spent decades attempting to develop humanoid robots that are both practical and resemble people in appearance and behavior. Because it enables us to circumvent the inherent dimensionality of this obstacle, generative artificial intelligence has the potential to be a beneficial instrument for the current creation process. Moreover, the research underlines that generative artificial intelligence, capable of producing media such as text, images, and audio in response to prompts, appears to improve daily. In addition, numerous technological companies are currently building and releasing their competing systems.
Machine learning boosts three-dimensional bioprinting
Authors: Ning Hongwei , Zhou Teng , Joo Sang Woo
Published: May 2023

Three-dimensional (3D) bioprinting is a computer-controlled technology that combines biological factors and bioinks to print an accurate 3D structure in a layerby-layer fashion. 3D bioprinting is a new tissue engineering technology based on rapid prototyping and additive manufacturing technology, combined with various disciplines. In addition to the problems in in vitro culture process, the bioprinting procedure is also afflicted with a few issues: (1) difficulty in looking for the appropriate bioink to match the printing parameters to reduce cell damage and mortality; and (2) difficulty in improving the printing accuracy in the printing process. Datadriven machine learning algorithms with powerful predictive capabilities have natural advantages in behavior prediction and new model exploration. Combining machine learning algorithms with 3D bioprinting helps to find more efficient bioinks, determine printing parameters, and detect defects in the printing process. This paper introduces several machine learning algorithms in detail, summarizes the role of machine learning in additive manufacturing applications, and reviews the research progress of the combination of 3D bioprinting and machine learning in recent years, especially the improvement of bioink generation, the optimization of printing parameter, and the detection of printing defect.
Evolution of bioprinting and current applications
Authors: Mendoza-Cerezo Laura , M. Rodríguez-Rego Jesús , Macías-García Antonio , C. Marcos-Romero Alfonso , Díaz-Parralejo Antonio
Published: May 2023

Bioprinting is a very useful tool that has a huge application potential in different fields of science and biotechnology. In medicine, advances in bioprinting are focused on the printing of cells and tissues for skin regeneration and the manufacture of viable human organs, such as hearts, kidneys, and bones. This review provides a chronological overview of some of the most relevant developments of bioprinting technique and its current status. A search was carried out in SCOPUS, Web of Science, and PubMed databases, and a total of 31,603 papers were found, of which 122 were finally chosen for analysis. These articles cover the most important advances in this technique at the medical level, its applications, and current possibilities. Finally, the paper ends with conclusions about the use of bioprinting and our expectations of this technique. This paper presents a review on the tremendous progress of bioprinting from 1998 to the present day, with many promising results indicating that our society is getting closer to achieving the total reconstruction of damaged tissues and organs and thus solving many healthcare-related problems, including the shortage of organ and tissue donors.
Synthesis of biocompatible BSA-GMA and two-photon polymerization of 3D hydrogels with free radical type I photoinitiator
Authors: Li Teng , Liu Jie , Guo Min , Bin Fan-Chun , Wang Jian-Yu , Nakayama Atsushi , Zhang Wei-Cai , Jin Feng , Dong Xian-Zi , Fujita Katsumasa , Zheng Mei-Ling
Published: May 2023

Although the development of three-dimensional (3D) printing technology is growing rapidly in the biomedical field, it remains a challenge to achieve arbitrary 3D structures with high resolution and high efficiency. Protein hydrogels fabricated by twophoton polymerization (TPP) have excellent mechanical properties, high precision, and 3D architecture. However, a large number of the amino acid group in bovine serum albumin (BSA) would be consumed when the protein-based hydrogels use dyes of free radical type II photoinitiators. In this study, we use glycidyl methacrylate (GMA) to modify BSA molecules to obtain a series of BSA-GMA materials, allowing the protein material to be two-photon polymerized with a water-soluble free radical type I photoinitiator. The precisely controllable 3D structure of the BSA-GMA hydrogel was fabricated by adjusting the concentration of the precursor solution, the degree of methacrylation, and the processing parameters of the TPP technique. Importantly, BSA-GMA materials are free of acidic hazardous substances. Meanwhile, the water-soluble initiator lithium phenyl (2,4,6-trimethylbenzoyl) phosphite (LAP) allows TPP on the vinyl group of the GMA chain and thus without consuming its amino acid group. The as-prepared BSA-GMA hydrogel structure exhibits excellent autofluorescence imaging, pH responsiveness, and biocompatibility, which would provide new avenues for potential applications in tissue engineering and biomedical fields to meet specific biological requirements.
Optimization of exergetic performance and payback period of organic rankine cycle integrated vapor compression refrigeration system based on exergy, economic, and environmental criteria
Authors: GOYAL Ashwni , SHERWANI Ahmad Faizan
Published: May 2023

In this paper, a multi-objective optimization study is carried out to determine the optimal exergetic performance (𝜂𝑒𝑥) and the payback period (PB) of the organic Rankine cycle (ORC) integrated vapor compression refrigeration (VCR) system based on exergy, economic, and environmental criteria using non-dominated sort genetic algorithm-II (NSGA-II). Moreover, a sensitivity analysis is carried out to improve the exergetic performance of the system. The working fluid, the pinch-point temperature difference of the ORC evaporator (ΔToep ), con-denser (ΔTpcond), and the VCR evaporator (ΔTpve), cooling water inlet temperature (Tcw1), chilled fluid temperature (Tcf2), and heat-source inlet temperature (Th1) are taken as the decision vari-ables. The results of this study indicate that butane is the most suitable working fluid for op-timal exergetic efficiency, 𝜂𝑒𝑥 (33.7%) and payback period, PB (4.9 years) of the system. The optimal values of other decision variables such as Th1, Tcw1, Tcf2, ΔToep , ΔTpve , and ΔTpcondare 378 K, 313 K, 276 K, 10 K, 5 K, and 5 K respectively.