bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D.
Published: July 2023

Supplementary Fig. 2 shows Ingenuity pathway analysis (IPA) predictions for European American/ Caucasian American (EA/CA) ARHigh/mCSPC (LNCaP, VCAP, 22RV1), ARLow/mCRPC/NEPC (PC-3, PC-3M, DU145) and African American (AA) ARHigh/mCSPC (MDA-Pca-2b) PCa cell lines as well as normal prostate cell lines RWPE1 and RWPE2.   IPA predicted A) Diseases and biological pathways for development of ARLow/mCRPC/NEPC. Major pathways are cell movement, morbidity, mortality, migration, invasion, survival, viability and development of vasculature- vasculogenesis and angiogenesis. B) Causal network pathway for development of ARLow/mCRPC/NEPC, which include oxidative phosphorylation, p70S6K, unfolded response, TREM1 signaling, NF-kB signaling, ERK5 signaling, IL-8 signaling, BAG2 signaling, Integrin signaling and VEGF signaling. C) IPA predicted HIF1α and EMT as key pathways associated with PCa development in African Americans (AA).
Data from Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
Authors: Croushore Emma E. , Koppenhafer Stacia L. , Goss Kelli L. , Geary Elizabeth L. , Gordon David J.
Published: July 2023

Abstract
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in the synthesis of deoxyribonucleosides and is required for DNA replication. Multiple types of cancer, including Ewing sarcoma tumors, are sensitive to RNR inhibitors or a reduction in the levels of either the RRM1 or RRM2 subunits of RNR. However, the polypharmacology and off-target effects of RNR inhibitors have complicated the identification of the mechanisms that regulate sensitivity and resistance to this class of drugs. Consequently, we used a conditional knockout (CRISPR/Cas9) and rescue approach to target RRM1 in Ewing sarcoma cells and identified that loss of the RRM1 protein results in the upregulation of the expression of multiple members of the activator protein-1 (AP-1) transcription factor complex, including c-Jun and c-Fos, and downregulation of c-Myc. Notably, overexpression of c-Jun and c-Fos in Ewing sarcoma cells is sufficient to inhibit cell growth and downregulate the expression of the c-Myc oncogene. We also identified that the upregulation of AP-1 is mediated, in part, by SLFN11, which is a replication stress response protein that is expressed at high levels in Ewing sarcoma. In addition, small-molecule inhibitors of RNR, including gemcitabine, and HDAC inhibitors, which reduce the level of the RRM1 protein, also activate AP-1 signaling and downregulate the level of c-Myc in Ewing sarcoma. Overall, these results provide novel insight into the critical pathways activated by loss of RNR activity and the mechanisms of action of inhibitors of RNR.
Developmental changes in individual alpha frequency: Recording EEG
data during public engagement events
Authors: Turner Christopher , Baylan Satu , Bracco Martina , Cruz Gabriela , Hanzal Simon , Keime Marine , Kuye Isaac , McNeill Deborah , Ng Zika , van der Plas Mircea , Ruzzoli Manuela , Thut Gregor , Trajkovic Jelena , Veniero Domenica , Wale Sarah P. , Whear Sarah , Learmonth Gemma
Published: July 2023

Statistical power in cognitive neuroimaging experiments is often very low. Low sample size can reduce the likelihood of detecting real effects (false negatives) and increase the risk of detecting non-existing effects by chance (false positives). Here, we document our experience of leveraging a relatively unexplored method of collecting a large sample size for simple electroencephalography (EEG) studies: by recording EEG in the community during public engagement and outreach events. We collected data from 346 participants (189 females, age range 6-76 years) over 6 days, totalling 29 hours, at local science festivals. Alpha activity (6-15 Hz) was filtered from 30 seconds of signal, recorded from a single electrode placed between the occipital midline (Oz) and inion (Iz) while the participants rested with their eyes closed. A total of 289 good-quality datasets were obtained. Using this community-based approach, we were able to replicate controlled, lab-based findings: individual alpha frequency (IAF) increased during childhood, reaching a peak frequency of 10.28 Hz at 28.1 years old, and slowed again in middle and older age. Total alpha power decreased linearly, but the aperiodic-adjusted alpha power did not change over the lifespan. Aperiodic slopes and intercepts were highest in the youngest participants. There were no associations between these EEG indexes and self-reported fatigue, measured by the Multidimensional Fatigue Inventory. Finally, we present a set of important considerations for researchers who wish to collect EEG data within public engagement and outreach environments.
Parapharyngeal Abscess: Antibiotic-only or Open Surgical Drainage?
Authors: Zhao Xiaoyun , Ma Jingru , Wu Xiufa , Wei Chunsheng
Published: July 2023

Objective:Many problems of parapharyngeal abscess (PPA), such as etiology, predisposing factors, and therapeutic methods, are still controversial. We aim to investigate the characteristics of PPA to better understand the therapeutic effects of the disease. Methods: We retrospectively collated the medical record reviews of 49 PPA patients who were treated as PPA inpatients when a patient was hospitalized and diagnosed with PPA, and empiric antibiotics were used. Only if the drug treatment was ineffective, the abscess was large, or the disease continued to progress, and surgical treatment was adopted. Results: In total, 49 patients who met the research criteria were identified. Streptococcus was the most common organism in PPA patients. The morbidity of diabetes in PPA patients was higher than the prevalence of diabetes in the overall population. Interestingly, the length of hospital stay was shorter in the antibiotic-only group than in the surgery group ( P < 0.05). Furthermore, the duration from onset to treatment in the antibiotic-only group was shorter than in the surgery group. Conclusion: Our treatment protocol is effective. Antibiotic-only method is also recommended for the PPA which was effective for the empiric antibiotics and localized. Early diagnosis and treatment of PPA could ultimately reduce the severity of PPA.
Vibration characteristics of turbocharger rotor system considering internal thread texture parameters of semi-floating ring bearing
Authors: Zhong Xinli , Jiang Jingjun , Bin Guangfu , Chen Anhua , Yang Feng
Published: July 2023

The internal thread texture causes changes in the dynamic characteristics of the oil film of the semi-floating ring bearing, which affects the amplitude of vibration and operating life of the turbocharger rotor system. Based on the fluid lubrication theory, the oil film governing equation of a semi-floating ring bearing with surface texture parameters is derived. The effects of the texture depth, position, and number of turns of the internal thread on the dynamic characteristics of the bearing oil film, such as the maximum pressure, load-carrying capacity and stiffness damping, are analyzed. Taking a type of turbocharger as an example, a hydrodynamic model is established to analyze the oil film lubrication in the semi-floating ring bearings, and the dynamic characteristic of the oil film is analyzed by computational fluid dynamics method. The results show that the maximum pressure, bearing capacity, and stiffness damping coefficient of oil film increase firstly and then decrease with the increase of texture depth and the number of thread turns in the range of journal rotation speed from 1000 to 20,0000 r/min. Compared with the non-texture bearings, the dynamic characteristics coefficients of the oil film such as bearing capacity and stiffness damping increase the most, when the depth of texture is 0.006 mm and the number of thread turns is 9. Secondly, the dynamic characteristic coefficient of oil film is improved when the texture is distributed in the middle than on both sides. The thread texture with appropriate parameters can suppress the rotor system vibration amplitude. The conclusion can provide a reference for the design of textual parameters of semi-floating ring bearings.
Predictions of friction and temperature at marine cam-tappet interface based on mixed lubrication analysis with real surface roughness
Authors: Hua Deliang , Li Renze , Shi Xiujiang , Sun Wen , Shi Fangpeng , Lu Xiqun
Published: July 2023

The working conditions of cam-tappet pairs in marine diesel engines are directly influenced by the engine output power, the operational speed, the temperature, as well as the components surface micro-morphology, etc., which cause the cam-tappet pairs work in the mixed lubrication state, thus the interfacial friction, pressure and temperature rise are vital to engine performance, efficiency, and durability. An interfacial friction–temperature prediction model for the cam-tappet pairs, considering the effects of transient working conditions and the real surface roughness, is developed in the present study, based on the theories of the transient mixed EHL and the heat transfer under the condition of a fast moving heat source. The numerical results of surface temperature rise are compared with those from the Blok formula, and a good agreement is found. The obtained results show that the presence of 3D roughness may lead to a decrease in the lubricant film thickness, and the surface temperature rise of tappet may exceed 700 K, which is close to the material scuffing temperature, causing the surface failure due to scuffing and wear. If increasing the cam speed and base circle radius within certain range, it may lead to the increment of film thickness and reduction of surface temperature rise, thus the lubrication effectiveness is increased. In addition, using cast aluminum bronze may significantly reduce the surface temperature rise and improve the interfacial characteristics.
Dead or alive? Reassessing the health of the death penalty and the prospects of global abolition
Authors: Dudai Ron
Published: July 2023

There is a growing position among human rights advocates, academics and UN officials, predicting “the death of the death penalty”, and forecasting that it will completely disappear soon. This article questions and problematizes this prediction, exploring the assumptions, premises and gaps that underpin the optimistic outlook. Based on analysis of abolitionist discourse, three fallacies are identified and analyzed: a progressive fallacy, assuming the death penalty is a barbaric anachronism in the “civilized” modern world and displaying a teleological belief in its demise; a classificatory fallacy, entailing defining-down the prevalence of the death penalty through the category of “de-facto abolition”; and a functional fallacy, assuming that repudiating the death penalty as a crime-fighting tool will cause its demise, overlooking its transformation into an institution serving political-symbolic functions. In concluding, I suggest viewing the global death penalty as bifurcated: dying as an ordinary law-enforcement tool, but relatively healthy as an extraordinary political symbol.
No time to read? How precarity is shaping learning and teaching in the humanities
Authors: Kadmos Helena , Taylor Jessica
Published: July 2023

Humanities educators are frequently frustrated by students’ poor engagement in reading. The contemporary student experience is characterised by disruption and precarity. Similarly, is that of teachers who work in casual employment. This discussion is located within broader conversations around the neoliberal university, but aims to make more visible ways that teaching and learning are increasingly shaped by precarity, and consequences for the humanities. It describes what precarity in higher education looks like and considers the kinds of strategies that students and their teachers are positioned to develop by virtue of engaging in education under such conditions, amid chaos, making these meaningful through the learning theory of connectivism. This discussion points to some examples of humanities-based pedagogical innovations that seek to strengthen reading skills, while also acknowledging the changing circumstances of students to point towards avenues for ongoing consideration, reflection, and innovation in the humanities.
Assessment of a wearable fall prevention system at a veterans health administration hospital
Authors: Osborne Thomas F , Veigulis Zachary P , Arreola David M , Vrublevskiy Ilya , Suarez Paola , Curtin Catherine , Schalch Evann , Cabot Rachel C , Gant-Curtis Angela
Published: July 2023

Objective

In-hospital falls are a significant cause of morbidity and mortality. The Veterans Health Administration (VHA) has designated fall prevention as a major focus area. The objective of this report is to assess the performance of a new sensor-enabled wearable system to prevent patient falls.

Methods

An integrated sensor-enabled wearable SmartSock system was utilized to prevent falls at the acute care wards of a large VA hospital. Individual patients were only provided the SmartSocks when they were determined to be at high risk of falling. All fall count rates, with and without using the SmartSock, were evaluated and compared for individual patients. SmartSock sensor and electronic health record data were combined to assess the system's performance from February 10, 2021, through October 31, 2021.

Results

There were 20.7 falls per 1000 ward days of care (WDOC) for those not using the SmartSocks compared to 9.2 falls per 1000 WDOC for patients using the SmartSocks. This represents a reduction of falls by more than half. These findings are further confirmed with a negative binomial regression model, which showed the use of the SmartSock had a statistically significant effect on the rate of falls ( p = 0.03) when length of stay was held constant and demonstrated the odds of fall incident rate of 0.48 (95% CI, 0.24–0.92), that is less than half compared to when patients were not wearing the SmartSock.

Conclusion

The use of a sensor-enabled wearable SmartSock fall prevention system resulted in a clinically meaningful and statistically significant decrease in falls in the acute care setting.
Symbiotic propagation of Dendrobium bigibbum Lindl. with selected saprophytic Basidiomycota
Authors: BAUTISTA NONNATUS S. , VALENTINO MARY JHANE G.
Published: July 2023

Abstract. Bautista NS, Valentino MJG. 2023. Symbiotic propagation of Dendrobium bigibbum Lindl. with selected saprophytic Basidiomycota. Biodiversitas 24: 3519-3527. Compatible mycorrhizal association of orchids with fungi is required for the germination and seedling development. In the present study, the mycorrhizal association of Dendrobium bigibbum with three species of saprophytic Basidiomycota, in particular, Volvariella volvacea, Lentinus tigrinus, and Pleurotus florida were evaluated. Co-culture technique was carried out during rhizoid and seedling development of D. bigibbum. Results revealed that the growth of D. bigibbum in rhizoid and seedling stages was enhanced when symbiotically grown with V. volvacea and L. tigrinus. D. bigibbum grown with V. volvacea had the highest mean length of the 1st leaf during the rhizoid stage. In seedling stage, V. volvacea and L. tigrinus significantly increased the growth of D. bigibbum in terms of length of 2nd leaf and fresh weight of the seedlings. For the length of root, increase in mean length was observed only in D. bigibbum co-cultured with L. tigrinus. In addition, the presence of peloton colonization was observed both in rhizoid and seedling stages. Thus, both V. volvacea and L. tigrinus formed compatible mycorrhizal association with D. bigibbum.
Management of Soft-tissue Defects of Hand in a Conflict Combat Zone: A Case Series
Authors: Prasad Manish , Sharma Vibhu , Vig Varun , Nair Vipin Venugopal , Panjiyar S P , Thakur Kamparsh
Published: July 2023

Introduction: Managing soft-tissue defects of hand is a challenging problem for any surgical team, even more in a field hospital setting of a conflict combat zone, where resources are scarce and such cases due to blunt trauma, gunshot wound and deep tissue infections are common. Case Report: We present four different cases, all middle aged males, who sustained injuries due to crush, low velocity gun shot, and defects post-debridement of acute onset infections following abrasions. The first patient was managed with doubled pedicled abdominal flap, the second patient was managed with external fixation for fracture, and cross finger flap for the defect. The third and fourth patients had similar presentations of acute onset deep soft tissue and bony infection, out of which one was managed with full thickness skin graft from anterior abdominal wall and the other with bi-pedicled abdominal flap. All the patients had good functional outcomes with no functional restrictions at follow-up of 12 weeks. Conclusion: All the cases were performed in a challenging situation of a highly active combat field zone, with limited resources and lack of availability of a trained hand surgeon. An early soft-tissue coverage, as soon as possible, was crucial in saving the hand function and guaranteeing a speedy return to function in view of lack of a professional hand surgery team and specialized microsurgery equipment. Keywords: Hand defect, UN field hospital, combat zone.
LA GESTIÓN ESTATAL DE LA DIVERSIDAD. ENFOQUE DIFERENCIAL EN LA POLÍTICA DE REPARACIÓN A LAS VÍCTIMAS AFROCOLOMBIANAS
Authors: Juan Pablo Estupiñán
Published: July 2023

En este artículo analizo aspectos de la implementación de la política de reparación a  víctimas afrocolombianas del conﬂicto armado. Propongo que la noción de  enfoque diferencial constituye el campo jurídico-semántico en el cual se confgura la red de actores, relaciones sociales y sentidos que son disputados en torno a la política. A partir de relatos etnográfcos, analizo los actores y tensiones durante la implementación de la política en dos dimensiones: en el diseño institucional en el ámbito nacional, y en la puesta en marcha de la política en el nivel local. Concluyo reﬂexionado sobre el riesgo del enfoque diferencial de convertirse en un tecnicismo o en una meta institucional, perdiéndose sus fundamentos políticos de reconocimiento de derechos en medio de la burocracia estatal.
The role of sodium-glucose cotransporter type 2 inhibitors on the path to cardiovascular well-being in type 2 diabetes mellitus and chronic kidney disease
Authors: Demidova T. Yu. , Skuridina D. V.
Published: July 2023

SGLT-2 inhibitors first emerged as a new class of oral hypoglycemic drugs with modest efficacy in lowering HbA 1c levels, which were also capable of inducing weight loss and lowering blood pressure without a significant risk of hypoglycemia. However, an analysis of the results of studies conducted to assess cardiovascular outcomes in patients with type 2 diabetes mellitus (DM) during iSGLT-2 therapy showed evidence of nephroprotection, which led to the initiation of trials on renal outcomes. The data obtained showed that the protective effects of iSGLT-2 against cardiovascular and renal complications of type 2 diabetes do not directly depend on their hypoglycemic activity, while their particular clinical significance is demonstrated in reducing the risk of hospitalization for heart failure (HF), progression of diabetic kidney disease (RDK), as well as a reduction in the incidence of major adverse cardiovascular events (MACE).

Today it is known that against the background of diabetic nephropathy, cardiovascular consequences become more serious. CKD patients with diabetes are more likely to die from cardiovascular causes than from end-stage renal disease. Diabetic kidney disease appears to be not only a marker of increased cardiovascular risk, but also involved in the pathogenesis of cardiovascular disease. An increase in traditional risk factors such as hypertension, hyperlipidemia, and obesity cannot fully explain the worse cardiovascular and fatal outcomes in CKD.

This review will focus on the role of iSGLT-2 in the outcomes of type 2 DM complicated by the development of CKD, and will highlight the putative mechanisms of the nephroprotective action of this group of drugs.
Hypercalcemia syndrome: differential diagnostic search and treatment tactics
Authors: Demidova T. Yu. , Lobanova K. G. , Korotkova T. N.
Published: July 2023

Hypercalcemia is a common laboratory finding. The most common causes of high blood calcium are primary hyperparathyroidism, tertiary hyperparathyroidism, parathyroid cancer, malignant neoplasms, long-term therapy with lithium and thiazide diuretics, vitamin D intoxication, which require a different approach to treatment. Therefore, it is important for a doctor to be able to conduct a differential diagnostic search for hypercalcemia syndrome in order to establish the cause of high blood calcium and determine the correct tactics for managing patients.
Pathology of carbohydrate metabolism in primary hyperparathyroidism: epidemiological and clinical characteristics
Authors: Bibik E. E. , Dobreva E. A. , Eremkina A. K. , Mokrysheva N. G.
Published: July 2023

Primary hyperparathyroidism (PHPT) is characterized by disorders of not only mineral metabolism, but also other kinds of the human metabolism. Due to the increased frequency of cardiovascular risk factors among patients with PHPT, the study of the carbohydrate metabolism pathology in this cohort of patients will allow developing optimal approaches to their timely diagnosis and treatment.

Aim. To determine the frequency and describe the clinical features of carbohydrate metabolism disorders in patients with PHPT.

Material and methods. A single-center retrospective study of adults with PHPT was carried out with an assessment of the main parameters of mineral and carbohydrate metabolism before surgical treatment of the disease. The exclusion criteria were the absence of PHPT remission or a recurrence of the disease after parathyroidectomy; pregnancy, lactation. The frequency of various disorders of carbohydrate metabolism in PHPT, the comparative characteristics of mineral parameters in patients with and without them, as well as the severity of type 2 diabetes mellitus in PHPT were determined. In addition, potential relationships between the parameters of various types of metabolism have been studied.

Results. The study was based on a clinical information of 367 patients with PHPT, most of whom had a symptomatic form of the disease. The overall incidence of prediabetic disorders was 4,9% (95% CI: 3-8). Type 2 diabetes mellitus was previously diagnosed in 45 patients (12%, 95% CI: 9-16), there were no cases of first diagnosed diabetes mellitus. Individuals with impaired carbohydrate metabolism had a statistically significantly higher body mass index and lower values of osteocalcin (27,2 [24,2; 30,4] kg/m2 vs 32,7 [28,1; 39,4 kg/m2 and 48,1 [34; 76,3] ng/mL vs 33,1 [20,8; 51,8] ng/mL, respectively, for all parameters p<0,001). Among patients with type 2 diabetes mellitus, 36 people (80%) took hypoglycemic therapy, 14 of which received metformin monotherapy and 8 received two-component therapy, including metformin. 5 people were on insulin therapy. Diabetic nephropathy was diagnosed in 36,4% of patients, 15,4% had signs of diabetic retinopathy, symptoms of diabetic distal neuropathy were observed in 61,9% of patients with PHPT. Fasting glucose and glycated hemoglobin were negatively correlated with bone metabolism, and also expectedly depended on the glomerular filtration rate.

Conclusion. Among patients with PHPT, type 2 diabetes mellitus is more common than in the general population. The likely reason of this may be insulin resistance, that can be caused by the effects of bone metabolites, primarily osteocalcin. In most cases, metformin makes it possible to achieve compensation for diabetes mellitus in PHPT.
Covariance edges matrix of geometric elements
Authors: Florian Blachere , Houman Borouchaki
Published: July 2023

In this paper, we introduce a new matrix associated with polygons and polyhedrons, namely the covariance edges matrix. We show that, for a regular polygon or polyhedron the corresponding matrix is proportional to the identity of size two or three. Based on this fact, we propose, as an application, several algebraic shape quality measures for convex polygons or polyhedrons. Furthermore, this matrix may be related to the metric of a simplex. Future studies will be devoted to the definition of the covariance edges matrix for higher elements and real applications to mesh optimisation.
ENERGY EFFICIENCY ANALYSIS METHODS OF REFRIGERATION PLANTS
Authors: Talyzin Maksim
Published: July 2023

Cold supply systems occupy a leading place in many industries. Their improvement is currently associated with two main areas: energy saving and ecology.
The problems of energy saving are paid great attention both at the state level (Federal Law No. 261-FZ "On Energy Saving and on Improving Energy Efficiency and on Amending Certain Legislative Acts of the Russian Federation") and by the owners of refrigeration equipment.
The costs of electricity consumed by cold supply systems make up a significant part both in the total balance of energy consumption of the enterprise (for catering enterprises it ranges from 48% to 60%) and in the country's total energy consumption (for example, the share of energy consumption of air conditioning systems in Europe ranges from 2% to 6%).
Along with this, the ratification by the Russian Federation of Montreal (Resolution No. 539 of the Government of the Russian Federation of 27.08.2005) and the Kyoto (FZ 128-FZ of November 4, 2004) Protocols, the entry into force of European Regulations 517/2014 governing the decommissioning of refrigerants with global warming potential GWP above 2500, for example, the R404A and R507A currently in active use, as well as the adoption by the Russian Federation of new environmental legislation in connection with the signing of the Paris Agreement, leads to the need to use new refrigerants, which are not always more efficient than traditionally used solutions and require changes to the technological scheme of refrigeration systems.
These factors lead to the need to improve efficiency calculation methods based on classical methods of thermodynamic analysis.
METHOD FOR EVALUATING EFFICIENCY OF REFRIGERATION UNITS BASED ON SINGLE-STAGE COMPRESSION CYCLE
Authors: Talyzin Maksim
Published: July 2023

The development of automation and programming tools is one of the priority areas determined by the State Program "National Technology Initiative," which requires the development of methods on the basis of which algorithms will be built.At the same time, energy saving is one of the directions for the development of refrigeration equipment. This issue is paid attention both at the state level (Federal Law No. 261-FZ "On Energy Saving and Increasing Energy Efficiency and Amending Certain Legislative Acts of the Russian Federation") and by the users of refrigeration equipment themselves, since the share of electricity consumed by refrigeration equipment is a significant part of the total energy balance of a particular enterprise. For example, the share of energy consumption of air conditioning systems in Europe ranges from 2% to 6%.The existing systems for monitoring the operating parameters of the refrigeration plant do not fully use their resource, since they are very often used only to identify emergencies and alarm them.This article describes the procedure for assessing the energy efficiency of refrigeration plants operating on a single-stage compression cycle with single throttling, which allows to evaluate both at the design stage and during the operation of the refrigeration plant, and allows to obtain a distribution of losses by elements and processes of the refrigeration plant.
İşyerinde Hekimlere Yönelik Şiddetin Değerlendirilmesi ve Hekimler Üzerindeki Etkileri
Authors: Usluoğulları Fatih Hitami , Yurtseven Nurşen Turan
Published: July 2023

Objective: One of the biggest problems that physicians face in their work life is the violence that they are exposed to. This study aims to determine the frequency and characteristics of the violence experienced by physicians in the workplace and to determine how the exposure to violence affects physicians’ job satisfaction, suicide risk, burnout levels.
Methods: This study is a cross-sectional study with descriptive characteristics. Four hundred-eighteen volunteer physicians participated. The questionnaires distributed to the participants were reviewed with the literature and consisted of sociodemographic information, questions about violence, Minnesota Job Satisfaction Scale, Suicide Probability Scale, Maslach Burnout Scale.
 Results: It was observed that 58.4% of physicians were exposed to workplace violence during the last year and there was a significant difference in terms of gender, age, title, institution, duration of work and department. Physicians who suffered violence in the workplace during the last year; emotional exhaustion, insensitivity and suicide probability levels were higher, job satisfaction and personal success levels were lower than physicians who didn’t suffer.
Conclusion: In order to prevent violence against health workers and physicians and to reduce their possible effects, changes in the health policies implemented, improvement of working conditions, reorganization of the health environment, especially in emergencies, and a deterrent law that the Turkish Medical Association has been expressing for years should be enacted.
İzmir’de COVID-19 Pandemisi Öncesinde ve Sonrasında Yapılan Tüm Adli Otopsilerin Retrospektif Olarak Değerlendirilmesi ve Karşılaştırılması
Authors: Tunçez Ferhat Turgut , Yeşiltepe Gözde , Karabulut Uğur , Tokdemir Mehmet
Published: July 2023

Objective: In this study, in the 2 year period before and after the first date of the COVID-19 case in Türkiye (between 11.03.2019-10.03.2020 11.03.2020-10.03.2021) İzmir Forensic Medicine Group Presidency we aimed to show the effects of the SARS-CoV-2 pandemic by examining the autopsies and autopsy findings performed through the forensic autopsy records.
Methods: Our study was planned as a retrospective study of autopsies performed in İzmir Forensic Medicine Group Presidency. The data of autopsies performed between 11.03.2019-10.03.2020 and 11.03.2020-10.03.2021 in the İzmir Forensic Medicine Group Presidency will be analyzed in terms of age, gender, cause of death, origin of death and mode of death.
Results:A total of 4604 autopsy cases were examined in our study. In the pre-pandemic period, the number of female cases was 472 (21.4%), the number of male cases was 1734 (78.6%), the most common form of death was suspicious death with 1192 (54%), and the most common origin was 1039 (47.1%) was detected as natural death. After the pandemic, these numbers were found to be 413 (17.2%) for women, 1985 (82.8%) for men, 1398 (58.3) suspicious deaths and 1072 (44.7%) natural deaths.
Conclusion: As in all areas of life, changes have occurred in forensic autopsy practice with the COVID-19 pandemic, and we think it is important to share the data we have obtained as a result of examining and analyzing all forensic autopsies performed during and before the SARS-CoV-2 pandemic in Izmir for two years.
Gıda Aspirasyonunda Psikotrop İlaçların Rolü: Olgu Sunumu
Authors: Çoban İsmail , Mutlu Emre
Published: July 2023

Although swallowing disorders are quite common in psychiatric patients and especially in patients with schizophrenia, they have not been adequately studied. Swallowing disorders are an important source of morbidity and mortality in patients with schizophrenia as a result of acute asphyxia resulting from airway obstruction or an insidious aspiration and pneumonia. Most swallowing disorders in schizophrenia are attributed to two main causes: The changes in eating and swallowing due to the disease itself and the effects of psychotropic drugs. Behavioural changes related to the illness include eating too fast or taking in inappropriately large amounts of food. Treatment-related problems are most often associated with drug-induced extrapyramidal side effects, including drug-induced parkinsonism, dystonia, and tardive dyskinesia. In this case report, it is aimed to share the psychotropic drugs detected in a schizophrenic patient who developed mechanical asphyxia due to food aspiration and to examine their possible effects on food aspiration.
Speech strategies and tactics used by participants in modern educational webinars
Authors: Krylova Maria N.
Published: July 2023

The texts of modern educational webinars are analyzed in order to identify the main speech strategies and tactics used by their participants. It is noted that the genre of the educational webinar has recently acquired significant relevance due to the wide spread of the distance learning format. It was revealed that the speech strategies and tactics used by webinar speakers are focused on establishing close intellectual, emotional and psychological contact with webinar recipients. In this regard, the informing strategies, imperativeness and cooperation become the main speech strategies at webinars. For a webinar speaker, it is important to give the audience accurate and verified information, organize its perception and create an atmosphere of cooperation and joint activity at the webinar. Webinar participants use the argumentation strategies, positive presentation, self-presentation, gaining authority, “distance management”, comic impact, and others. Within the framework of the strategies used, the educational participants webinars resort to constructive speech tactics, such as the tactics of referring to the knowledge that the addressee has, the image tactics, the establishing speech contact tactics, the step-by-step explanation tactics, as well as the integration tactics, demonstrating openness and interest, useful information, appealing to authority, self-promotion, etc. Destructive strategies and tactics in the educational webinar genre construction are practically not involved.
Long-term Oncological and Functional Outcomes after Laparoscopic Partial Nephrectomy with Hyperselective Embolization of Tumor Vessels in a Hybrid Operating Room
Authors: Frantz Ulysse , Bouvier Antoine , Culty Thibaut , Zidane Merzouka , Lebdai Souhil , Bigot Pierre
Published: July 2023

Laparoscopic partial nephrectomy (LPN) after hyperselective embolization of tumor vessels (HETV) in a hybrid operating room (HOR) that combines traditional surgical equipment with advanced imaging technology, is a non-clamping surgical approach to treat localized kidney tumors that have shown promising short-term results. The aim of this study was to evaluate the long-term oncological and functional outcomes of this procedure. All consecutive patients treated for a localized kidney tumor by LPN after HETV between May 2015 and October 2022 in a single academic institution were included in the study. Clinical, pathological and biological data were collected prospectively in the uroCCR database. We evaluated perioperative data, postoperative complications, surgical margin and modification of renal function after surgery. We included 245 patients. Median tumor size was 3.2 (2.5-4.4) cm. The R.E.N.A.L. complexity was low, medium and high for 104 (43.5%), 109 (45.6%) and 26 (10.9%) patients, respectively. Median LPN time was 75 (65 -100) min and median blood loss was 100 (50-300) mL. Surgical postoperative complications occurred in 56 (22.9%) patients with 17 (5.7%) major complications. The median preoperative Glomerular Function Rate (GFR) was 90.5 (77-101.8) mL/min and the median GFR variation at 6 months was -7.5 (-15- -2) mL/min. Malignant tumors were present in 211 (86.1%) patients and 12 (4.9%) patients had positive surgical margins. After a median follow-up of 27 (8-49) months, 20 (8.2%) patients had a tumor recurrence and 4 (1.6%) died from cancer. The use of a HOR to perform LPN after HETV is a safe and efficient non-clamping approach to treat localized kidney tumors.
Effects of adsorption and filtration processes on greywater microbiological contamination and the potential human health risk reduction
Authors: Mortula Md Maruf , Fattah Kazi Parvez , Iqbal Fatima , Khan Zahid
Published: July 2023

Recycling treated greywater (GW) for onsite, non-potable applications can reduce the potable water demand typically used for non-potable purposes. The conventional methods for GW treatment are limited in their ability to remove wide-ranging pollutants in ways that are inexpensive and use low energy. For this reason, effective and low-cost onsite treatment options are in demand. This study examines the effectiveness of sand filtration (SF), granulated blast furnace slag (GBFS), and activated carbon (AC) in the treatment of GW from a residential apartment building in Sharjah, United Arab Emirates. The study relies on four different pilot-scale experimental setups to investigate the effectiveness of SF, AC, and GBFS in treating microorganisms from GW and evaluate the microbial risk reduction using these treatment processes. A quantitative microbial risk assessment (QMRA) approach is used for risk assessment. Results show that GBFS achieves a higher reduction of total coliform (TC) (0.54–2.05 log removal) and fecal coliform (FC) (1.96–2.30 log removal) than AC. SF improves reduction by 0.13–3.39 log removal and 1.11–3.68 log removal for TC and FC, respectively. The study also reveals substantial FC and Escherichia coli risk reduction by SF, AC and GBFS.
Clinical Applications of Sunscreens and Formulation Advancements
Authors: Sunena  , Tomar Deepali , Jawla Sunil
Published: July 2023

Sunscreens cover the big market ratio in terms of cosmetic applications, but the therapeutic
necessity of sunscreen still needs to be uncovered in the clinical context. Clinically, sunscreens
are being employed more often nowadays as a result of the rising consequences of skin
malignancies and the photodamaging effects of UV radiation. Sunscreens are essential to prevent
aging by shielding the skin from the harmful effects of ultraviolet (UV) radiation. Over the recent
decades, there has been a significant evolution in the usage of sunscreens as photo protectants.
The demand for sunscreen formulations will inevitably rise as more people become aware of the
protection that sunscreens provide against tanning, photoaging, non-melanoma skin cancers, premalignant
skin lesions, and skin melanomas. The novel contemporary formulation techniques are
also beneficial in enhancing the product's aesthetic look and quality. Recently, regulatory agencies
have also started paying attention to the regulation of the clinical application, efficacy, and safety
parameters related to sunscreen. This review underlines the pathophysiological response of UV
exposure with the therapeutic applications of sunscreen in various dermatological conditions and
the recent formulation advancements in the development of sunscreen.
BMI for Age Percentile As Criteria for Assessment of Obesity in Children and Adolescents
Authors: Dewan Manju
Published: July 2023

The most useful population-level measure of overweight and obesity is BMI. This measure is same for men and women of all ages. But it should not be thought to be as final factor to calculate the same body fat percentage in different individuals. Various proposed reference values for overweight and obesity exist for BMI, but the combined effect of BMI and BMI for age percentile recommendations is scarce. A total 2048 children participated in the epidemiological survey. According to Body Mass Index in the study, 66.26% subjects were found to be malnourished in the total population. The degree of obesity had been observed as Pre-obese 3.81% and Obese-I 3.81% and Obese-II were 0.88%. Pre-obese, obese-I and obese-II boys were more than the girls. According to BMI-for-age percentile, overall, 6.20% of children and adolescents were at risk of overweight and 4.39% were overweight during health survey while 24.80% are underweight.
The Implementation of Scientific Approach to Increase Mathematics Understanding Ability on Algebraic Derivative Materials
Authors: Fathurrohman Muhamad Taufik , Sugandi Asep Ikin
Published: July 2023

Referring to the objectives of learning mathematics and NCTM, one of the abilities that must be developed is the ability to understand mathematics. The importance of having the ability to understand mathematics includes this ability listed in the learning of mathematics in the 2006 KTSP mathematics curriculum and the 2013 curriculum. This study aims to examine the increased understandingÂ Â of the material concept of derivatives of algebraic functions in class XI high school students. This type of research is classroom action research. This research was conducted on class XI high school students for the 2020/2021 academic year, consisting of 16 students. The instrument used is a test of students' mathematical understanding abilities, in the form of 6 questions that focus more on students' understanding abilities regarding the derivative of algebraic functions; observation sheet for teachers and students to see the condition of the implementation of the action. This study shows that students' mathematical understanding abilities have increased as seen from the questions tested on each test with an increase in mastery from initially 31.25% to 56.25%. The results of this study indicate that the application of a scientific approach can improve the comprehension skills of class XI students on material derived from algebraic functions.
A Simple Correction to the Apparent Conductivity from Surface Magnetic Dipole Data
Authors: França Érico Tenório , Régis Cícero , Da Cunha Luciano Soares , Françoso Maria Teresa
Published: July 2023

A method to improve the determination of apparent conductivities from near-surface electromagnetic dipole data should be simple and easy to implement and use in the field. With this objective, we present a simple correction to the apparent resistivity from surface magnetic dipole data. In contrast with the traditional approach that uses a truncated series to approximate the fields, the proposed method calculates the apparent conductivity by solving a minimization problem using the complete homogeneous half-space analytical solutions for the magnetic field of the dipole sources. In comparison with previous approaches to improve apparent conductivity estimation, this is an extremely simple solution, easily implemented and demanding almost negligible computer time and memory. To illustrate the method, applications to synthetic 2D data and real data are presented. The results show that the method can improve the responses of conductive zones which are difficult to perceive in the raw field data.
Perspektywy rozwoju polskiego rolnictwa w świetle proponowanego kształtu WPR 2014-2020
Authors: Wieliczko Barbara
Published: July 2023

Propozycje przedłożone przez Komisję Europejską w 2011 r. w odniesieniu do kształtu Wspólnej Polityki Rolnej 2014-2020 sugerują, iż charakter tej polityki nie ulegnie zasadniczym zmianom. Oznacza to, iż w dalszym ciągu WPR nie będzie oferowała wystarczająco efektywnych i skutecznych instrumentów wspierania przemian strukturalnych w polskim rolnictwie. Szczególnie niepokojące, nie tylko z punktu widzenia polskiego rolnictwa, ale również w odniesieniu do konkurencyjności sektora rolnego całej Wspólnoty, są propozycje dotyczące zazielenienia płatności bezpośrednich. Podniesienie zobowiązań związanych z ochroną środowiska oraz wprowadzenie wymogów oznaczających de facto konieczność odłogowania 7% UR gospodarstwa rolnego może znacząco zmniejszyć konkurencyjność unijnego rolnictwa, którą już teraz systematycznie ograniczają wysokie koszty produkcji, wynikające zarówno z kosztów pracy, jak również z konieczności ponoszenia kosztów dotyczących przestrzegania norm i ograniczeń w zakresie środowiska naturalnego i dobrostanu zwierząt.
Sustainable Development of a Build-Up Area Taking into Account the Environmental Safety in Urban Conditions
Authors: Manzhilevskaya S. E.
Published: July 2023

Introduction. The sustainable design system of a built-up area requires integration of many types of information and ensuring the constant involvement of users, community members and various specialists throughout a building’s life cycle. The holistic designing approach implies focusing on the functional relationship between different parts of a building or a building complex as a whole that increases the complexity of a project. The key principle underlying sustainable buildings is an integrated design process taking into account the principles of environmental safety.The present article focuses on the analysis of the managerial and organizational methodology used by the civil engineering professionals in the context of sustainable construction. The design, management and arrangement of a construction site for a building’s reconstruction or a large scale build-up within the urban area boundaries require the development of measures and solutions for the storage and use of toxic chemicals, allocating the places for hazardous wastes collection and disposal, wastewater treatment – the results of operation of a previous structure or a building complex. All these factors need appropriate monitoring, assessment of risks and measures of ecological recovery of a land plot, in cases when the original objects and territories change their functional designation and are rebuilt into objects having impact on the environment.Materials and Methods. The development of sustainable design principles for arranging a construction site of capital construction facility on the areas that were exposed to long-term impact during the previous buildings’ and structures’ operation requires working-out the algorithms, methodology for assessment and monitoring the environmental situation on a construction site. The implementation of the present solutions requires the analysis of the sources of pollution, the duration of exposure, the nature and degree of construction site’ soil layer pollution. The development of modern managerial, organisational and technological solutions will minimise the processes of territory recovery and create sustainable construction operations.Results. As a result of the conducted research there were developed: the algorithms for assessing the ecological state of a construction site soil layer, the recommendations on the methodology for a build-up area ecological state assessment and monitoring aimed at setting the sustainable design of the organisational and technological solutions within an investment and construction project.Discussion and Conclusions. The implementation of the sustainable design processes in the investment and construction project on a build-up area soil layer preservation, the monitoring and assessment of its state enable avoiding extra costs due to the absence of the need for soil reclamation and purchase of soil of a different chemical composition from that originally formed in a particular area, and due to ensuring maximum possible preservation of vegetation.