bluuebunny/crossref_metadata_2025 huggingface dataset:
THE WORLD’S OLDEST POTS: ON THE DISPERSAL OF THE CERAMIC INNOVATION AMONG EURASIAN HUNTER-GATHERERS SINCE THE LATE GLACIAL PERIOD
Authors:   Christian Albrechts Universität zu Kiel, Piezonka Henny
Published: June 2021

The earliest ceramic vessels of the world have been produced in southern China by Late Glacial hunter-gatherers in the remote times around 18,000 calBC. Over the following millennia the new technology became known among forager communities in the Russian Amur region, in Japan, Korea, Transbaikalia and ultimately appeared also in the Urals and in eastern and northern central Europe. Contrary to common views of pottery as part of the “Neolithic package”, the Eurasian hunter-gatherer ceramic tradition is an innovation that developed completely independent of other Neolithic traits such as agriculture, animal husbandry and sedentary lifestyle. The paper explores the chronological sequence of the appearance of hunter-gatherer ceramic vessel production on the basis of radiocarbon dates in northern Eurasia from the Pacific coast to the Baltic and outlines promising methodological approaches that currently play a role in researching this much-discussed topic.
Work of collaboration in the creation of literary works under the legislation of Ukraine and France
Authors: Kedia Yuliia
Published: June 2021

Kedya Y. Work of collaboration in the creation of literary works under the legislation of Ukraine and France. This article highlights particular legal frameworks, definition and practice of applicability of co-authorship (works done in collaboration) by publishers and co-authors. In addition, we will cover the differences between the co-authorship upon creation of a work and collective works. The analysis is based, inter alia, on comparison of French Ukrainian laws, thus, giving an opportunityto crystalize particular shortcomings and advantages of set forth by Ukrainian laws related to above matters.The research formulates a comprehensive overview of the defining and basic rulesof co-authorship, comparative analysis of (a) collective works with (b) works of collaboration,as well as analysis of shortcomings and advantages set forth by Ukrainianlaws. The author reviews and analyzes main provisions in Ukrainian legislation, suggestspossible solutions of the main problems, deliberates ways of laws developmentin future. The paper is based on author’s professional experience.Main conclusions of comparative analysis of legal regulation definition of co-authorship definition in Ukraine and France are as follows:

•According to Intellectual Property Code of France only physical persons may be considered co-authors, including literary works. At the same time, Ukrainian law is silent on this matter. It must be noted that according to the Law of Ukraine «On Copyright and Related Rights» (the «Copyright Law»), co-authors are persons whose joint work creates a literary work. At the same time, the definition given to the author by said law limits creative participation to physical person;•The Copyright Law defines the concept and set forth the pre-conditions for co-authorship. However, unlike the French Code of Intellectual Property (Article L113-2), no due attention has been paid to the concept of a collective work. The authors believe that it is advisable to supplement Article 19 of the Copyright Law by (i) the definition of a collective work and (ii) to distinguish between the concepts of a composite work and a collective work;•It is necessary to harmonize the conclusion of an agreement between co-authors in the Civil Code of Ukraine and the Copyright Law;•Research uncovered certain flaws in the conclusion of agreements between co-authorson creation of a collective work;•Examining the Intellectual Property Code of France was helpful for finding the difference between collective works and co-authorship of a particular work.Key words: work of collaboration, composite work, collective work, copyright, intellectual rights, literary work
A new approach determining the scope of legal protection of industrial designs in Ukraine
Authors: Yudina Hanna
Published: June 2021

Key words: scope of legal protection, informed user, overall impression, degree of author's freedom, registered industrial design, unregistered industrial design

This article analyzes the norms of the Law of Ukraine «On the Protection of Rights to Industrial Designs» as amended on October 14, 2020, in the part that regulates relations as to the establishment of the scope of legal protection for an industrial design. A comparative analysis as to the norms of wording the Law of Ukraine «On the Protection of Rights to Industrial Designs» dated on October 14, 2020, and the norms of the said Law as of 05.12.2012, has been carried out, and as a result of which it was found that the norms of wording the Law as of 05.12.2012 concerning legal relations pertaining to the establishment of the scope of legal protection and the fact of the use of an industrial design in a product or later registered industrial design, as well as the requirements for means by which the scope of legal protection was found, differ significantly from the norms wording the Law as of 05.12.2012. In particular, it was established that prior to the adoption of the Law as amended on 14.10.2020, the scope of legal protection for the industrial design, instead of being based on the impression produced on an informed user, was determined by the set of essential features presented on the images of the product andgiven in the description of the industrial design. There are also differences in means used to establish the scope of legal protection for the industrial design. If in the wording of the Law as of 14.10.2020 only pictorial means are used, then in the wording of the said Law as of 05.12.2012 — together with pictorial means descriptive verbal means are also taken into account (the list of essential features of the industrial design is given in the description). Also distinctive is that the wording of the Law as of 14.10.2020 did not provide legal protection for the appearance of the product solely due to its technical functions, the appearance of the product, the size and the shape of which must be accurately reproduced in order that one product can be mechanically connected to another one or located inside, around or in front of another product in such a way that each one can perform its function and the features embodied or used in the product as part of the assembled make and are being invisible during normal use of the product.
Changing paradigm of supplementary protection of inventions in the national legislation of Ukraine
Authors: Homeniuk Anastasiia
Published: June 2021

Key words: patent term extension, supplementary protection, supplementary protectioncertificate, drug patents, patent legislation reform

The article is mainly aimed at distinguishingtwo mechanism: patent term extension which used to be applied inUkraine before the patent reform, and supplementary protection certificates whichwere introduced to national legislation in 2020.Patent term extension in the way it was provided in the Ukrainian Patent Law is arather simple mechanism that didn’t require much regulations. It used to provide additionalperiod of patent monopolies which was equal to the period which elapsed betweenthe date on which the patent application was filed and the date of the marketingauthorisation, not more than 5 years. Since there were no limitation on the type ofpatent (basic patent) or requirement of the first marketing authorization, this regimeprovided an opportunity to extend not only basic patent term, but also all secondarypatents related to one drug. This created a situation when duration of patent monopolyfor one drug exceeded 35 years.Provided that national pharmaceutical industry is oriented on manufacturing ofgeneric drugs, supplementary protection certificates are more appropriate forUkraine. Firstly, this is due to the limitation of effective patent life to 15 years whichis more feasible considering the national context. Another positive thing about SPCsis some uncertainty in relation to definition of the subject matter and scope of SPCprotection. That means that the country can have some freedom in determining theways of its interpretation. However, it should be noted that such indeterminacy is agrey zone. Thus, it is necessary to consider how the country can benefit from the supplementaryprotection regimen. Since the pharmaceutical sphere is very sensitive,the SPC issues have direct effect on public health and access to treatment. So, the articlejustifies the general idea that implementation of new legislation provisions shallbe aligned with both ensuring pharmaceutical innovations and guaranteeing that thepublic health needs are still a priority. Therefore, considering the long-term negativeeffect of the patent term extension regimen, the new SPC approach should be as balancedas possible.
Criminal protection of objects of individualization in Ukraine and abroad
Authors: Nedohybchenko Yevheniia
Published: June 2021

Keywords: object of individualization, trademark, mark for goods and services,criminal liability, criminal legal protection

Problems of criminal law protection and protection of meansof individualization among the participants of economic circulation has not found itscoverage and analysis in the legal literature.Legal regulation of industrial property protection at the international level takesplace within a number of agreements: the Paris Convention for the Protection of IndustrialProperty of 1883, the Madrid Agreement Concerning the International Registrationof Marks of 1891, the Hague Agreement Concerning the International Registrationof Industrial Designs of 1925, and others.The article examines the experience of criminal law protection of trademarks ofthe following countries: USA, Great Britain, Germany, Switzerland, Ukraine.The author speaks about the need to unify approaches to criminal prosecution inUkraine. This will facilitate effective litigation. Establish liability for infringement oftrademark rights. Will contribute to the improvement of the national system of protectionof intellectual property rights. Increase safeguards to protect intellectualproperty rights. It will raise Ukraine's image in the world.The laws of the countries define in detail the scope of rights of owners to intellectualproperty. The law provides a list of actions that are considered a crime.In the United States, a criminal case is initiated by the federal government or thestate. In the Federal Republic of Germany, most infringements of intellectual property rights are governed by civil law. An offense is a criminal offense if it is committedwith intent.Ukraine also has special legislation. Criminal liability is established in the relevantarticles of the Code. These articles are in different sections of the Criminal Codeof Ukraine. Such placement of norms negatively affects the punishment of violators.There is a need to unify approaches to prosecuting offenders. This will facilitate effectivelitigation. Establish liability for violations of the law. Will contribute to the improvementof the national system of protection of intellectual property rights. Increasingguarantees of protection of intellectual property rights. It is necessary to do so byintroducing the relevant into the Criminal Code of Ukraine.
Objects of intellectual property rights: general terms of protection
Authors: Bakhareva Olena
Published: June 2021

Keywords: wine go and brown models, promises, sort of roslin that breed of twarin,trade marks (marks for goods), commerce (form) naymenuvannya, geographic significance,komertsiyna tamnytsya, computer programs

Intellectual property is the result of human creativity: works of art and science, inventionsand utility models in all fields of human activity, industrial designs, trademarks(marks for goods and services), commercial (brand) names, information products,selection achievements, etc. Intellectual property is created as a result of purposefulmental work of human intellect, the result of which is something new, characterized byuniqueness, originality, uniqueness.According to the provisions of the Civil Code of Ukraine, an intellectual property rightis a person’s right to the result of intellectual, creative activity or another object of intellectualproperty right, defined by this Code and another law. Intellectual property rightsare personal non-property intellectual property rights and (or) property intellectual propertyrights, the content of which in relation to certain objects of intellectual propertyrights is determined by this Code and other law. Intellectual property rights are inviolable.No one may be deprived of intellectual property rights or restricted in their exercise,except in cases provided by law.The Commercial Code of Ukraine provides a list of intellectual property, leaving itopen and states that the general conditions for the protection of intellectual propertyrights to objects are determined by the Civil Code of Ukraine. In the Civil Code ofUkraine, the fourth Book «Intellectual Property Law» is devoted to the issue of intellectualproperty. The Civil Code of Ukraine provides a more extensive list of objects of intellectualproperty rights, defines their concepts.According to Article 420 of the Civil Code of Ukraine, the objects of intellectual propertyrights, in particular, include: literary and artistic works; computer programs; datacompilation (database); implementation; phonograms, videograms, broadcasts (programs)of broadcasting organizations; scientific discoveries; inventions, utility models,industrial designs; arrangement of semiconductor products; innovation proposals; plantvarieties, animal breeds; commercial (brand) names, trademarks (signs for goods andservices), geographical indications; trade secrets.The purpose of my article is to summarize information about the objects of intellectualproperty rights, disclosure of their concepts with reference to relevant regulatorysources. Therefore, to simplify the reader's perception and search for concepts in differentsources, it was decided to group them in one text. I hope that the information providedwill be useful.
Сombating unfair registrations and using means of individualization in the conditions of digital transformation
Authors: Androshchuk Hennadii
Published: June 2021

Key words: intellectual property, unfair competition, means of individualization, valuation,squatter, losses, digital transformation, artificial intelligence

The article examines the economic, legal and institutional aspects of combating unfair registration and use ofmeans of individualization (trademarks, brand names, geographical indications, domainnames) in the context of digital transformation. The formation of theoretical and methodologicaland methodological foundations for the protection of the rights of their owners,improving the efficiency of experts of intellectual property agencies, law enforcementagencies, tools for digital search and use of artificial intelligence (AI) to ensure the effectivenessof the institution of individualization. The economic and legal aspects of foreign(in the jurisdictions of China, USA, EU) and domestic legislative and law enforcementpractices to combat the phenomenon of unfair registration and use of personalization,digital search tools and the use of AI are analyzed. It is shown that over the next fiveyears, 30 to 50% of product searches will be by voice rather than text, so the impact of AIon the way a product is purchased will have significant economic and legal implicationsfor individualization legislation. The means of counteracting unscrupulous applicants inthe USA have been studied. The U.S. Patent and Trademark Office (USPTO) has developedrules under which foreign applicants and trademark owners must be representedby a U.S. licensed attorney when filing trademark applications with the USPTO. Emphasisis placed on the introduction of legislative liability of e-commerce platforms forcounterfeit goods. The analysis of the last changes in the legislation of Ukraine on protectionof trade marks is carried out. It is shown that the new rules change the approachesto registration and protection of trademarks, create the possibility of their fair use.Digitalization, transition to e-document circulation in the Customs Register, improvementof the procedure for destruction of counterfeit goods are important anti-corruptionsteps in the activities of Ukrainian customs in the context of digital transformation of theeconomy.
Legal regulation of Innovation Park of the Poland
Authors: Postryhan Tetiana
Published: June 2021

1.      Hlibko S. V. Pravove rehuliuvannia diialnosti naukovoho parku yak subiekta  natsionalnoi innovatsiinoi systemy. Pravo ta innovatsii № 4 (20) 2017. S. 15−27.

2.      Ustawa z dnia 20 marca 2002 r. o finansowym wspieraniu inwestycji. URL: http://prawo.sejm.gov.pl/isap.nsf/download.xsp/WDU20020410363/U/D20020363Lj.pdf.

3.      Główny Urząd Statystyczny [Elektronnyi resurs]. URL: http://stat.gov.pl/

cps/rde/xbcr/wroc/Dzialalnosc_badawcza_i_rozwojowa.pdf.

4.      Medynska T. V., Cherevata R. Yu. Podatkove stymuliuvannia innovatsiinoi diialnosti v Ukraini ta Polshchi v umovakh yevropeiskoho vyboru. Ekonomika i suspilstvo. Vypusk # 13 / 2017. S. 1149−1156.

5.      Poland: Tax exemption for venture capital funds aims to foster innovation [Elektronnyi resurs]. URL: https://www.dlapiper.com/sv/sweden/insights/publications/2016/05/.

6.      Shliakhy rozvytku ukr. nauky Informatsiino-analitychnyi biuleten. Dodatok do zhurnalu «Ukraina: podii, fakty, komentari.» № 5 (126) traven 2016. [Elektronnyi resurs]. URL: http://www.nas.gov.ua/text/pdfNews/stymuly.pdf.

7.      [Elektronnyi resurs]. URL: https://bbn.uksw.edu.pl/node/332.

8.      [Elektronnyi resurs]. URL: https://naukawpolsce.pap.pl/aktualnosci/news,

411269,resort-nauki-przedstawil-biala-ksiege-innowacji.html.

9.      [Elektronnyi resurs]. URL: http://obywatelenauki.pl/2016/10/komentarz-on-do-bialej-ksiegi-innowacji/.

10.    Act of 20 October 1994 on Special Economic Zones [Elektronnyi resurs].

URL: http://invest-ksse.com/acts of law,22.

11.    [Elektronnyi resurs]. URL: https://www.worldfzo.org/Portals/0/

OpenContent/Files/487/Poland_FreeZones_Atlas.pdf.

12.    Tkach S. M. Rozvytok innovatsiinoi infrastruktury Ukrainy ta Polshchi. 92 Vypusk 3 (119), m. Lviv.

13.    Kuryliak Ye. Yu. Klasterni formy orhanizatsii vyrobnytstva u hlobalnii ekonomitsi. Dys. na zdobuttia naukovoho stupenia k.e.n. Ternopil – 2015. URL: http://dspace.wunu.edu.ua/bitstream/316497/749/1/14.10.2015_disertacya_kurilyak-ye.yu.pdf.
Activity of legal education regarding the popularization of inventive activity
Authors: Chomakhashvili Olena
Published: June 2021

Keywords: inventor activity, invention, inventions, intellectual property

The article is sanctified to the debatable question of necessity orimpossibility of popularization of inventor activity. The review of concepts is done invention,inventor activity, inventor. Possibilities are considered as exactly the state musttake care to the questions of creation of necessary terms for maintenance and strengtheningof the intellectual potential, and also for the search of ways of him quality development.Foreign experience is analysed in the field of it. The special attention is spared toorganization of work of young people through competitive activity, that became important direction of public policy of the almost entire industrially developed countries. Successfulrealization of scientific and technical and innovative politics in Ukraine is impossiblewithout activation of creative individuality and invention, that it is directly relatedto development of both higher and professional education.Successful implementation of scientific, technical and innovation policy in Ukraine isimpossible without the activation of creative individuality and invention, which is directlyrelated to the development of both higher and professional education. The materialand technical base of many (especially technical) higher education institutions today isoutdated, in need of updating, as well as teaching methods. The system of branch institutesof advanced training has also been destroyed, enterprises do not have the funds forin-house training, the motivation for inventive activity has decreased.It is important to maintain a positive experience. The organization of youth creativitythrough competitive activities has become an important area of public policy in almostall industrialized countries. One of the main directions of the invention is the state programsfor the development of technical creativity of youth. Ministries and departments,corporations and firms take part in the implementation of such programs. The WIPOconducted a study aimed at generalizing progressive forms and methods of state stimulationof inventive activity in industrialized countries.The Ukraine, unlike industrialized countries, does not have such a long tradition inholding such competitions. But what has already been done is valuable to society. It remainsto multiply this experience.
The history of the development of civil procedural law of Ukraine on judicial protection of the property legal right to land
Authors: Shabalin Andrii
Published: June 2021

Keywords: civil procedural protection, court, violation of private property rights toland, civil procedure

The article is devoted to the study of the historical and legal aspects of the judicial procedure for theprotection of property rights to land in Ukrainian legislation. The author investigates themain stages of legal protection of property legal rights to land, in each historical periodits own characteristics of the aforementioned procedure for the protection of the correspondingproperty right are determined. Considerable attention is paid to the issues ofthe peculiarities of legal regulation and judicial procedure for the protection of propertylegal rights to land. In this scientific article, the author pays considerable attention to thedevelopment of judicial protection of legal property rights to land in the historical periodof the emergence of the independent state of Ukraine (1917−1918 yy). The author of thearticle writes that during this period the legal right to land received significant development:the land plot could be inherited, the right to rent the land could also be inherited.The procedure for the judicial protection of the legal right to land had no legal peculiarities.The author describes that during the Soviet period of Ukraine's existence, there was no legal property right to land. Only the state could have legal property rights to land.This means that the courts did not protect the private property legal right to land. Onlywhen Ukraine became an independent state did a private property legal right to landemerge. During this historical period, a significant number of legal instruments for theprotection of proprietary legal rights to land appeared in the legislation of independentUkraine. The property legal right to land was protected by the court. It is the judicialprotection of the property legal right to land that is democratic and meets the Europeandemocratic standards for the protection of property rights. The modern features of thegenesis of legal protection of property legal rights to land, which are protected by thecourt in the civil procedure of Ukraine, have been investigated. The author has createdand described new stages in the development of civil procedural protection of legal propertyrights to land.
Improvement of intellectual property management in Ukraine
Authors: Orliuk Olena , Korohod Nataliia
Published: June 2021

Keywords: the European Union, innovative development, intellectual property, commercialutilization, legal governance, management, digital economics

In the below article, the intellectual property management is considered asone of the strategic goals of intellectual property development in Ukraine. The articleemphasized the intellectual property and efficient copyrights protection as the basic pillarfor the innovative digital economics of the country.The triggers are defined which started the full-range reform of the intellectual propertyarea development in Ukraine since 2016. The goals were: 1) implementation of theupdated particular legislation for the intellectual property area in 2019-2020, whichadopted the provisions of the Association Agreement with EU along with relevant Europeanstandards for the area; 2) roll-out of the institutional reform resulting in establishmentof the lawful ground for the national governing body for intellectual property supervision.The approaches to the economics theory, governing are analyzed along with nationallegislation provisions as for term «intellectual property management» and strategic directionsfor the intellectual property area development. It gives grounds that term «intellectualproperty management» is to be used not only on organizations and enterpriseslevel as it is proposed for years by scientific works, but also at much wider scale — at economicsareas and even national economics level. Considering the strategic planning andits practical implementation within short and long term prospective, the intellectualproperty management is proposed to consider at institutional level through the means ofthe tasks and functions setting up with their particular realization.The problems are defined which hinder the intellectual property managementprocesses as well as the factors of external and inhouse affecting the process. The principlesfor intellectual property management based on the science researches, are proposedto exercise upon the subject both at macroeconomics and enterprise level, taking into accounttheir specifics.The pace of Ukraine as the Eastern partnership country, towards the integration tothe innovative digital environment of EU, is being analyzed. The further steps are proposedaimed at intellectual property management enhancement on the institutional level.
Workflow Modelling of Construction Projects
Authors: Murphy Ellen , Champneys Alan
Published: June 2021

Data on the progress of about a hundred construction projects were provided by Heathrow Airport. Most projects have many adjustments in their scope which impact the cost and schedule. Can an optimised scheduling of the project lead to decreased costs and more rapid completion? To answer this, both a data-centric approach and a complementary mathematical model were developed to better understand the effect of resource constraints on cost and price extension due to resource competition of concurrent projects. The model takes the form of a discrete time stochastic simulation, whose parameters are t to the existing data. While more data is needed to validate the model, the results suggested that gains can be made if more thoughtful scheduling of projects is implemented, and also if the prioritisation of projects is monitored and adjusted intelligently, in particular by prioritising completion of smaller projects.
Modelling of Teaching for Pre-School Children with Mental Retardation
Authors: Shapko Olga
Published: June 2021

The article discusses the experience of using models in remedial work with children with mental retardation of preschool age in kindergarten conditions. Examples of outlines of lessons with this category of preschool children 6-7 years old are offered. The reactions of children to the introduction of models are illustrated. The aim of the article is to show that models are an effective technique for children with mental retardation to perceive cognitive material, because they stimulate children to independent voluntary purposeful activity. This is facilitated by the model algorithm, which includes generalized images that are familiar to children and do not cause them difficulties. We have taken into account that for children with mental retardation the operation "comparison" is one of the difficult ones, but through it the relations between objects and phenomena of the external world are learned. Comparison therefore plays an important role in cognition Comparison helps to generalise and systematise knowledge. The process of comparison is a necessary condition for generalisation. The model can help children with mental retardation to find similarities between objects, which for them is rather more difficult than finding differences.
Inhibition of Hepatitis B Virus by AAV8-Derived CRISPR/SaCas9 Expressed From Liver-Specific Promoters
Authors: Yan Kun , Feng Jiangpeng , Liu Xing , Wang Hongyun , Li Qiaohong , Li Jiali , Xu Tianmo , Sajid Muhammad , Ullah Hafiz , Zhou Li , Zhou Limin , Chen Yu
Published: June 2021

Curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal, and the persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is a key barrier that is hard to break through using the drugs currently approved for HBV treatment. Due to the accuracy, efficiency, and cost-effectiveness of genome editing, CRISPR/Cas technologies are being widely used for gene therapy and in antiviral strategies. Although CRISPR/Cas could possibly clear cccDNA, ensuring its safety is requirement for application. In our study, we analyzed the liver specificity of several promoters and constructed candidate promoters in the CRISPR/Staphylococcus aureus Cas9 (SaCas9) system combined with hepatotropic AAV8 (whereby AAV refers to adeno-associated virus) to verify the efficacy against HBV. The results revealed that the reconstructed CRISPR/SaCas9 system in which the original promoter replaced with a liver-specific promoter could still inhibit HBV replication both in vitro and in vivo. Three functional guide RNAs (gRNAs), T2, T3, and T6, which target the conserved regions of different HBV genotypes, demonstrated consistently better anti-HBV effects with different liver-specific promoters. Moreover, the three gRNAs inhibited the replication of HBV genotypes A, B, and C to varying degrees. Under the action of the EnhII-Pa1AT promoter and AAV8, the expression of SaCas9 was further decreased in other organs or tissues in comparison to liver. These results are helpful for clinical applications in liver by ensuring the effects of the CRISPR/Cas9 system remain restricted to liver and, thereby, reducing the probability of undesired and harmful effects through nonspecific targeting in other organs.
The state of myocardial contractility and the quality of life in occupational diseases of the respiratory system
Authors: Babanov S.A.
Published: June 2021

The article is devoted to the study of clinical, instrumental features and quality of life in occupational respiratory diseases in industrial workers, taking into account the data
of fibrobronchoscopic, spirographic and echocardiographic studies, as well as the study of quality of life parameters.
Role of oxidative stress in the pathogenesis of postmenopausal osteoporosis (literature review)
Authors: Bulgakova S. V. , Melikova A. V.
Published: June 2021

Postmenopausal osteoporosis is a disease of great medical and social significance for
the world population. At the same time, the underlying pathogenesis of this pathology is not fully understood. A large body of research suggests that endocrine changes associated with postmenopause can lead to disruption of redox homeostasis and oxidative stress that affects bone metabolism. This literature review analyzes the relationship between hypoestrogenemia, oxidative stress and postmenopausal osteoporosis, as well as methods for the prevention and treatment of these conditions.
Validity of the use of complexes containing phosphatidylserine in the practice of the therapist
Authors: Gizinger O. A.
Published: June 2021

The role of phosphatidylserine in providing the cognitive functions of the brain is considered. The Neuroexel complex, which contains phosphatidylserine and alpha-lipoic acid, can reduce cognitive imbalance caused by atherosclerotic changes, improve short-term and long-term memory. The use of a dietary supplement, which includes phosphatidylserine, can improve the adaptive potential of a person.
Immune disorders in the recuperation period. Justification of the Immunomax use
Authors: Gizinger O.A.
Published: June 2021

Impaired functioning of the immune system against the background of viral and bacterial diseases contributes to the generalization of inflammatory processes, the development of complications, and asthenia. Immunomax is the recommended preparation for correcting immune disorders. The active ingredient is Acid Peptidoglycan from Potato Sprouts with a molecular weight of 1000-40,000 kD; Registration number: P N001919 / 02. Immunomax® stimulates the expression of genes of signaling receptors of immunity, which increases their sensitivity of immunocytes to pathogens of different nature and causes an adequate immune response in the body in the presence of the pathogen.
The state of the intestinal microbiota and antimicrobial protection: obtaining and analyzing information
Authors: Gizinger O.A.
Published: June 2021

Despite significant progress in the study of the qualitative and quantitative composition
of microflora, there are many controversial issues related not only to diagnosis, but also to the treatment of dysbiotic disorders of the intestine. Dysbiotic disorders, characterized by a decrease in the qualitative and quantitative indicators of obligate and facultative microflora, can have a negative impact on human health. The doctor’s task is to restore the microbiocenosis of the gastrointestinal tract and the density of colonization of indigenous microflora, taking into account modern knowledge on this problem, presented in on-line training seminars.
Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment
Authors: Filippova E.V.
Published: June 2021

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.
A Fruitful or Wild French Vineyard? Distinguishing the Religious Roots of Albigenses and Waldensians in the Twelfth Century
Authors: Palombaro Ottavio
Published: June 2021

Much like how fruitful and wild branches are mixed in the same vineyard, there is a great deal of confusion when someone tries to discern the religious roots of heretical movements grown out of the Middle Ages. Two peculiar cases are often associated by confessional literature: Waldensians and Albigenses, demonized by Roman Catholic literature or romanticized by Protestant and modern Medieval fictional literature. In the quest for historical accuracy this paper intends to argue for the supremacy of certain contextual theological beliefs rather than socio-economic features alone in discerning the true nature of these movements despite their similarities and common persecution by the dominant Catholic religion. While the Albigenses reintroduced the ancient heresy of Gnosticism, the Waldensians were driven by a return to apostolic Christianity. The study also points out the need to analyze those movements beyond a one-dimensional approach in order to see the heterogeneity inside each movement, especially in their progressive evolution through time. Results point toward the need to reject an ancient origin thesis for the case of the Waldensians, whereas still allowing, in their case, a possible proto-Protestant connection.
Інструментарій місцевого економічного розвитку: теорія, методологія, практика
Authors: Ковальов А. І. , Корольова Т. С. , Сментина Н. В.
Published: June 2021

У монографії розкрито концептуальні положення забезпечення місцевого економічного розвитку. В основу наукових напрацювань покладено визнання трансформаційного внеску ролі стейкхолдерів у стимулюванні й забезпеченні сталого розвитку територіальних громад на основі Глобальних Цілей сталого розвитку у контексті формування національної економічної політики. Розкрито особливості та умови застосування окремих інструментів місцевого економічного розвитку та методико-прикладні аспекти забезпечення сталого розвитку територіальних громад. Основний акцент зроблено на потенціалі співробітництва територіальних громад в частині методології та напрямів реалізації державної стимулюючої політики. Результати дослідження дозволять розробникам стратегічних документів місцевого економічного розвитку планувати розвиток територіальних громад із врахуванням стратегічних інтересів, визначених із залученням усіх зацікавлених сторін, коригувати стратегічні плани з огляду на зміни зовнішнього світу й політики держави на шляху подолання економічних наслідків пандемії. Монографія розрахована на широке коло науковців та фахівців, зокрема державних службовців, а також всіх зацікавлених осіб.
Recursos en Internet para el estudio de los estadísticos de orden
Authors: Valenzuela Silvia , Batanero Carmen , Begué Nuria
Published: June 2021

Los estadísticos de orden tienen un papel destacado en el análisis exploratorio de datos y en la inferencia no paramétrica. Su enseñanza comienza en la educación secundaria y continúa en la universidad, niveles en que se han descrito dificultades en el cálculo e interpretación de estos estadísticos. El objetivo de este trabajo fue seleccionar y analizar algunos recursos didácticos interactivos que puedan facilitar la comprensión de los estadísticos de orden a los estudiantes de educación secundaria. Se comienza el artículo describiendo nuestros fundamentos, que son el enfoque ontosemiótico del conocimiento e instrucción matemática, el papel de la tecnología en la enseñanza y aprendizaje de la estadística y los resultados de la investigación previa sobre los estadísticos de orden. Una vez descritos el método de selección y análisis de la muestra, se presenta el análisis detallado de tres ejemplos, que comprende su descripción, la identificación de los objetos matemáticos requeridos para el trabajo con los mismos y las posibles dificultades de los estudiantes. Este análisis se complementa con el estudio de las diferentes componentes de la idoneidad didáctica del conjunto de recursos seleccionados y con una lista de otros recursos similares.
Educação Financeira: uma possibilidade de integração com a Educação Estatística
Authors: Pavan Perin Andréa , Ribeiro Campos Celso
Published: June 2021

Este estudo tem como objetivo identificar elementos que evidenciem a possibilidade de integração da Estatística com a Educação Financeira em aulas de Matemática para o ensino médio, no contexto da estratégia pedagógica da Modelagem Matemática, na qual trabalhamos uma experiência didática envolvendo o tema da inflação. Para análise do material coletado (relatório final da atividade) recorremos à abordagem qualitativa, por meio da análise do Discurso do Sujeito Coletivo. Nossas análises mostram que essa integração foi possível tendo como suporte a busca por uma medida estatística, média ou mediana, para indicar a variação dos preços em um determinado período. As análises dos dados revelam também a o desenvolvimento da competência crítica, a qual se deu por meio da construção de dois tipos de crítica, as quais denominamos de crítica epistemológica e sociopolítica. A crítica sociopolítica caracteriza-se por uma análise das estruturas sociais (problemáticas, sob seus pontos de vista) para o fenômeno estudado, que foi a taxa de inflação. Já a crítica epistemológica refere-se às ponderações sobre a escolha da melhor medida estatística para representar essa taxa, levando em consideração os procedimentos, as metodologias e os resultados alcançados. Também verificamos que esse tipo de crítica possui relações com raciocínio estatístico.
Dimensão cognitiva do letramento estatístico na perspectiva do Nepso: aprendizagem e tecnologias digitais em pesquisas de opinião
Authors: De Souza Oliveira Felipe Júnio
Published: June 2021

Parece ser razoável pensar na idoneidade de alguns profissionais que publicam informações científicas ou jornalísticas sobre temas de interesse social quando utilizam a Estatística para conferirem credibilidade ao que é divulgado. Contudo, preocupar-se com a leitura e apropriação de dados como forma de ação social (prevenção, planejamento, decisão e etc.) é um dos compromissos da Educação Estatística (EE). Nesse sentido, este artigo apresenta um recorte de uma investigação com 16 alunos do oitavo ano do Ensino Fundamental sobre o uso de tecnologias digitais (TD), como o Whatsapp, Facebook e Excel, na realização de uma pesquisa educativa de opinião baseada na abordagem de aprendizagem do projeto Nossa Escola Pesquisa Sua Opinião, ou Nepso. Em particular, a dimensão cognitiva do letramento estatístico é discutida na perspectiva da experiência com o Nepso a partir das aprendizagens constituídas e mobilizadas ao longo de oito encontros nos quais alunos pesquisaram sobre o tema entretenimento, enfoques e questões de interesse, todos escolhidos por eles. Destarte, indícios do desenvolvimento do letramento estatístico sinalizam para a importância do apoio das TD em situações de aprendizagem estatística e que o Nepso, com suas etapas, competências e habilidades, é um importante investimento didático para a EE.
Construção de gráficos de barras a partir de diferentes recursos: lápis e papel e software excel
Authors: Pontes Marcília , Lisbôa Guimarães Gilda
Published: June 2021

Esta pesquisa buscou investigar a aprendizagem de alunos do 5º ano do Ensino Fundamental em relação à compreensão da construção de gráficos a partir de tabelas com lápis e papel ou com o software Excel. Alunos de 4 turmas de escolas públicas de Paulista/Pernambuco participaram de um teste diagnóstico, uma sequência de ensino e um pós-teste. Duas turmas participaram dessa intervenção utilizando lápis e papel para a construção de gráficos e as outras duas turmas utilizando o software Excel. Nessas intervenções foram vivenciadas a construção de gráficos a partir de tabelas simples e dupla entrada e com grandezas numéricas diferentes. Foram observados avanços qualitativos em relação à representação dos dados em um gráfico de barras para os dois grupos e não houve diferença estatística significativa entre os recursos utilizados. Cada tipo de recurso contribuiu para o desenvolvimento de um tipo de habilidade, o que nos leva a crer que ambos deveriam ser estimulados no processo ensino aprendizagem de conhecimentos estatísticos.
Interfaces entre a pesquisa em Educação Estatística e o livro didático de Matemática: as produções acadêmicas e científicas do GT12 de 2016 a 2020
Authors: Paixão Borges Pedro , Severo Alan
Published: June 2021

O artigo apresenta resultados de uma pesquisa dedicada a investigar o trabalho desenvolvido pelos membros do Grupo de Trabalho 12 (GT12) da Sociedade Brasileira de Educação Matemática (SBEM) e tem como objetivo compreender o lugar que ocupam os livros didáticos de Matemática e paradidáticos nas pesquisas em Educação Estatística. Para isso, foram levantados artigos, capítulos de livros, livros completos, resumos e resumos expandidos publicados em anais de congresso referentes ao período de 2016 a 2020. Os resultados do levantamento, no entanto, não são muito animadores: apesar de grandes esforços serem empreendidos pelos pesquisadores do GT12 em diversos trabalhos voltados à Educação Estatística, ainda é pequeno o número de pesquisadores que se dedicam a estudos que focalizam os livros didáticos de Matemática e livros paradidáticos com temáticas relacionadas à Estatística. Há pouca quantidade de publicações dedicadas ao Ensino Médio e, de igual modo, poucos trabalhos realizados de maneira colaborativa, o que pode sugerir caminhos investigativos a serem trilhados ao longo dos próximos anos.
Estado do conhecimento: experiências de aprendizagem e de ensino de Estatística
Authors: Rubira Silva Camila , Pereira Laurino Débora
Published: June 2021

Neste artigo mapeamos e discutimos a produção científica sobre as experiências de aprendizagem e de ensino de Estatística, por meio do Estado do Conhecimento de artigos publicados em periódicos da área da Educação Matemática. Para tanto, o corpus foi composto por 31 artigos indexados entre jan./2010 e out./2020 em 24 periódicos eletrônicos brasileiros da área da Educação Matemática que estão classificados em estratos de qualidade A1, A2, B1 e B2. No tratamento dos dados adotamos os conhecimentos da Estatística Descritiva e a nuvem de palavras para apresentar informações sobre a quantificação, periodização, origem e a abordagem dos estudos, bem como as técnicas de Análise de Conteúdo (BARDIN, 1977) para a proposição de categorias temáticas. Por meio da categorização, emergiram cinco categorias que versam sobre as experiências de aprendizagem e de ensino de Estatística provenientes da: Educação Infantil e Anos Iniciais do Ensino Fundamental; Anos Finais do Ensino Fundamental; Ensino Médio; Educação Superior; e formação profissional para a docência. Consideramos que esta investigação possa contribuir para entendermos as experiências que tem sido (re)produzidas na aprendizagem e no ensino de Estatística, de modo a proporcionarmos práticas pedagógicas que possam ser mais significativas para estudantes e professores.
Contribuições das variáveis estatísticas na contextualização da função afim
Authors: Santana Cláudio Vitor , Mauricio Cazorla Irene , Cardoso Utsumi Miriam
Published: June 2021

Este artigo tem como objetivo analisar as possíveis contribuições das variáveis estatísticas na contextualização da função afim. Construímos a sequência “Covariação Estatística na Função Afim”, pautada nos princípios do Ciclo Investigativo e do Letramento Estatístico, e realizamos uma intervenção de ensino com 24 estudantes do 1º ano do Ensino Médio, do curso Técnico em Enfermagem, em seis encontros, com 12 horas aula. Os estudantes coletaram seus dados de variáveis antropométricas e os analisaram tanto de forma univariada, quanto das possíveis relações entre elas utilizando o diagrama de dispersão, escolheram dois pontos e encontraram a função afim correspondente, discutindo a razoabilidade de suas escolhas. Os estudantes conseguiram visualizar a distribuição dos dados, no contexto univariado e bivariado; todavia apresentaram dificuldades na formalização da função afim e a análise das relações entre as variáveis ainda estava influenciada pelas suas crenças e não pela evidência dos dados.