bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Google Glass for photographic documentation in veterinary forensic pathology (Preprint)
Authors: Piegari Giuseppe , Iovane Valentina , Carletti Vincenzo , Fico Rosario , Costagliola Alessandro , De Biase Davide , Prisco Francesco , Paciello Orlando
Published: January 2018

BACKGROUND

Google Glass is head-mounted device designed in the shape of a pair of eyeglasses equipped with 5.0 Mpx integrated camera and capable to take pictures with simple voice commands

OBJECTIVE

The aim of the study was to determine if Google Glass is fit for Veterinary forensics pathology purposes.

METHODS

A total of 44 forensic necropsies of 2 different species (22 dogs and 22 cats) were performed by 2 pathologists; each pathologist conducted 11 necropsies of every species and, for each photographic acquisition, the images were taken with Google Glass device and reflex camera Nikon D3200. Furthermore, the pictures were collected, divided in 3 groups (external appearance of the animal, organs and anatomical details) and evaluated by 5 forensic pathologists with a 5-point score system. The parameters assessed were: overall color settings, region of interest, sharpness and brightness. Moreover, to evaluate the difference in mean duration between necropsies conduced with glass and DSLR camera and to assess the battery consumption of the devices, an additional number of 16 necropsies were performed by 2 pathologists. In these cases, Glass was used for photographic report in 8 cases (4 dogs and 4 cats) and a reflex camera Nikon D3200 for the other 8 cases. Statistical evaluations were performed to assess the differences in ratings between the quality of the pictures taken by both devices.

RESULTS

the images taken by Google Glass received significantly lower ratings than those acquired by reflex camera for all 4 parameter assessed (P<.01). In particular, in the pictures of the Groups A and B taken by Glass, the sum of the ratings for 5 (very good) and 4 (good) was comprised between 50 and 77% for all 4 parameter assessed. The lowest ratings were observed in the pictures of group C with a sum of ratings for "5 and 4" of 21.1 % for region of interest, 26 % for sharpness, 35.5 % for overall color settings and 61.4% for brightness. Furthermore, we found a significant reduction in mean necropsy execution time conduced with the Google Glass with respect to the reflex group (P<.01). But, on the other hand, the former drained the battery very quickly.

CONCLUSIONS

These findings suggested that Glass was usable in veterinary forensic pathology. In particular, the images quality of the groups A and B seemed adequate for forensic photographic documentation purpose, although the images quality was lower if compared to a reflex camera. However, in this step of development, the high frequency of poor ratings observed in the pictures of the group C suggested that the device was not suitable for taking pictures of small anatomical details or close-up of the injuries.
Human Resource Performances of The Plantation and Workshop Divisions in The Tractor Readiness Service For The Operation of Sugarcane Plantation at PT Sweet Indo Lampung
Authors: Wibisono Olivia Esteevani , Waluyati Lestari Rahayu , Darwanto Dwidjono Hadi
Published: January 2018

The aims of this paper are to investigate the human resource performances at the workshop division in fixing damage tractors and to determine factors influencing their performances, and also to analyze the human resource performances on the plantation division in operating tractors to support the operation of sugarcane plantation. The survey method was conducted to collect primary data from the plantation and workshop divisions employees of PT Sweet Indo Lampung (PT SIL). Likert scale was applied to measure and determine variables of human resource performance and other relevant variables. Multiple linear regression models were used for the analysis measurement of human resources performances. The results show that human resource performances in the workshop and plantation divisions to operate tractors are in good category, but it still has to be improved. This includes the timelines to finish the work, obedience and loyalty of the employees, work planning and ability to manage the work. The factors that have positive influence on human resource performances are compensation, work environment, work relationship, and employee potential. The factor that has negative influence is expectation in developing performance. The longer time needed to repair the tractors was caused by the spare parts stock, number of mechanics that can handle the tractor, the workers skill and teamwork. Factors that cause damage on tractors are lack of maintenance, sloping area in sugar cane plantation, and lack of operators skill.
The Determinants of Paddy Field Conversion in Timor Island, East Nusa Tenggara Province (NTT)
Authors: Lulan Prischa , Darwanto Dwidjono Hadi , Hartono Slamet
Published: January 2018

The objectives of this research are: (1) to investigate the trend of paddy fields on Timor Islandand (2) to know the determinants of the conversion of paddy fields on Timor Island. TimorIsland consists of several districts such as Kupang District, South Central Timor District(TTS), North Central Timor District (TTU), Belu District and Kupang City. In fact, theyare the main rice-producing areas in the Timor Island, so they have an important role in thesupplying sufficient for locals. However, the regions are slowly started to be converted tonon-paddy-field use such as new settlements and other infrastructure development along withthe current economic development. The basic method used in this research was descriptiveanalysis and the location of research was determined purposively because this locationwas based on the consideration that there was a high growth of non-agricultural sectors inTimor Island; making it vulnerable to the reduction of paddy field area. The data used wassecondary data (2005-2014). The results showed that (1) the trend of rice field in Timor Islandis not significant with time variable. (2) The analysis of determinants of paddy field area inTimor Island using multiple linear regression with Ordinary Least Square (OLS) methodindicated that the factors affecting the conversion of wetland in Timor Island significantlyare the variable of building area and the number of industries.
Cost Analysis Of Replacement And Bearing Trailer Maintenance In Sugar Group Companies
Authors: Mastur Mastur , Masyhuri Masyhuri , Waluyati Lestari Rahayu
Published: January 2018

The purpose of this study are to understand (i) the costs and periods optimal of grease used for the replacement and maintenance bearing trailer in Sugar Group Companies (SGC), and (ii) the effect of a period and frequency of grease, lifetime bearing, frequency of replacement bearing in a year, unit trailer, brand bearing, and location of plant. The basic method used is descriptive and analytical. The location determined were in Workshop Division PT. ILP, PT. SIL, and PT. GPM. The analytical method used analytical tables, charts, and multiple regression analysis. The optimal period of grease based on bearing replacement and maintenance costs: (i) PT. ILP both brand A and B: Fertilizer Trailers (FT), Water Tank (WT), Side Tipping Trailer (STT), and Tank Moving (TS) is on 5 days, while Patria (PTR) and Disc Harrow (DH) on 3 days; (ii) PT. SIL both brand A and B unit trailer: FT, WT, PTR, STT, and TS on 5 days unless DH on 3 days; and (iii) PT. GPM for brands B for all unit (FT, WT, PTR, STT, TS, and DH) on 5 days, nor brand A except DH on 3 days. The factors that effect is a period of grease, bearing replacement and frequency of grease in one year. Cost of replacement and maintenance brand A < B. PT. ILP has the lowest costs than PT. SIL and PT. GPM.
La encuadernación del impreso antiguo en México: reflexiones sobre un problema de conocimiento patrimonial
Authors: COMPIANI ALBERTO , GARCÍA IDALIA , VELASCO THALIA
Published: January 2018

LA ENCUADERNACIÓN ES UNO DE LOS ELEMENTOS HISTÓRICOS DISTINTIVOS QUE FAVORECEN LA VALORACIÓN CULTURAL DEL LIBRO ANTIGUO COMO OBJETO PATRIMONIAL. EL ANÁLISIS DE LA ENCUADERNACIÓN COMO UN PROBLEMA DE CONOCIMIENTO ES UNA TAREA PENDIENTE EN EL TERRENO HISTÓRICO MEXICANO. CIERTAMENTE EXISTEN TRABAJOS ANTERIORES QUE MUESTRAN SU VALOR CULTURAL, PERO SON INICIATIVAS INCONCLUSAS QUE HAN POSIBILITANDO LA DESTRUCCIÓN DE NUMEROSAS ENCUADERNACIONES HISTÓRICAS POR LO CUAL EL MENSAJE DEL PASADO QUEDA MUTILADO. ESTE TRABAJO ANALIZA LAS TENDENCIAS DEL ESTUDIO DE LA ENCUADERNACIÓN EN MÉXICO Y DEFINE SU IMPORTANCIA COMO ELEMENTO PATRIMONIAL.
La frontera indómita. En torno a la construcción y defensa del espacio poético
Authors: RAYA ALONSO GRACIELA LETICIA
Published: January 2018

La frontera indómita. En torno a la construcción y defensa del espacio poético
Una aproximación al concepto de recuperación de información en el marco de la ciencia de la documentación
Authors: ARQUERO AVILÉS ROSARIO , SALVADOR OLIVÁN JOSÉ ANTONIO
Published: January 2018

LA NATURALEZA INTERDISCIPLINAR DE LA RECUPERACIÓN DE INFORMACIÓN PLANTEA PROBLEMAS NO FÁCILES DE RESOLVER A LA HORA DE ESTABLECER UNA DEFINICIÓN VÁLIDA PARA TODAS LAS CIENCIAS RELACIONADAS CON ESTE CAMPO. EL PRESENTE ARTÍCULO PRETENDE OFRECER UNA DEFINICIÓN DE RECUPERACIÓN DE INFORMACIÓN EN EL CONTEXTO DE LA CIENCIA DE LA DOCUMENTACIÓN. PARA ELLO, SE PRESENTA EN PRIMER LUGAR UNA VISIÓN GLOBAL A TRAVÉS DE LOS PRINCIPALES CONCEPTOS PROPORCIONADOS EN LA LITERATURA DEL CAMPO Y SE ANALIZA SU INFLUENCIA Y RELACIÓN INTERDISCIPLINAR CON LA INFORMÁTICA, LA CIENCIA DE LA INFORMACIÓN Y LA DOCUMENTACIÓN. POSTERIORMENTE, SE REALIZA UN ANÁLISIS INTRADISCIPLINAR DENTRO DE LA PROPIA DOCUMENTACIÓN CON EL OBJETIVO DE ESTABLECER SUS PROPIAS FRONTERAS Y DETERMINAR SU PROPIA IDENTIDAD.
Nature experience influences nature aversion: Comparison of South Korea and Germany
Authors: Lee Ju-Hyoung , Lee Sook-Jeong
Published: January 2018

People in modern metropolitan societies are often presented with only limited opportunities for experiencing nature in the wild, so that there is an increasing tendency for them to feel nature aversion, that is, an uncomfortable awkwardness when in a truly natural environment. Our purpose
in this study was to investigate nature aversion. In an international comparative study, we compared the nature aversion of people in South Korea and Germany, with results revealing that the degree of aversion toward a natural environment is higher in a society where nature experiences are
more limited and there is a low frequency of encounters. In this situation there is a risk that the perception of discomfort in a natural environment may develop further into nature experience phobia.
Is it possible to obtain zero estimates of genetic diversity? A case study of the Nigerian indigeneous goat breeds at the β-lactoglobulin gene locus
Authors: Ezewudo Emeka , Abubakar Geka , Egena Sunday , Alabi Olushola
Published: January 2018

The current investigation was conducted to appraise the genetic diversity and
genetic distance of three goat populations namely; Red Sokoto, Sahel and West
African Dwarf (WAD), in Nigeria, making use of blood samples collected from
20, 20 and 20 individual from which blood DNAs were extraction, respectively.
The DNAs extracted were used to study polymorphism at the ?-lactoglobulin
gene locus using RLFP-PCR process. Results revealed that the mean total
number of alleles was 1 while the effective number of alleles was also 1. The
percentage of polymorphic locus was 0% while Shannon?s information index,
observed homozygousity, expected heterozygosity, unbiased expected
heterozygosity and inbreeding coefficient (F) were all observed to be 0.000.
The pairwise Fst was 0.000 between all the breeds of goats. Variation within
and between the populations of goats was 0% at p>0.05. The genetic distance
between the goat breeds was 0.000. The present study revealed that RLFP-PCR
may not be a powerful tool for the study of the ?-lactoglobulin gene locus
and hence other methodologies should be employed for a broader judgment on
the genetic status of the goat population at the locus.
Blood parameters, carcass and meat quality of slaughter pigs with and without liver milk spots
Authors: Cobanovic Nikola , Vasilev Dragan , Dimitrijevic Mirjana , Teodorovic Vlado , Jankovic Ljiljana , Karabasil Nedjeljko
Published: January 2018

The aim of this study was to determine the influence of liver milk spots on
hematological, carcass and meat quality parameters in slaughter pigs. A
total of 120 pigs with a live weight of approximately 115 kg and six months
old were examined. Any signs of liver milk spots were recorded as present or
absent according to Welfare Quality? protocol (2009). A complete blood
picture was investigated. The following carcass quality parameters were
measured: live, hot and cold carcass weights, dressing percentage, backfat
thickness and meatiness. pH and temperature measurements were performed 45
minutes postmortem. Pork quality classes (PSE - pale, soft and exudative,
normal, DFD - dark, firm and dry meat) were determined according to Adzitey
and Nurul (2011) using pH45 value. Pigs with liver milk spots had
significantly higher middle-sized cell count (monocytes, eosinophils, and
basophils) and neutrophils count, but significantly lower red blood cell
count, hemoglobin concentration, hematocrit and MCV than unaffected pigs.
The same group of pigs had significantly lower live weight, hot carcass
weight, cold carcass weight, dressing percentage and meatiness compared to
the pigs free of milk spot lesions. Pigs showing liver milk spots had
significantly higher pH45 value and incidence of DFD meat than pigs without
pathological lesions in the livers. In conclusion, assessment of liver milk
spots at slaughter line has potential to serve not only as an indirect
measure of pig health and welfare, but also for the carcass and pork
quality.
Technological process of added value cheese making on registered agricultural households in Vojvodina
Authors: Popovic-Vranjes Anka , Krstovic Sasa , Jevtic Marija , Jurakic Zelјka , Strugar Katarina
Published: January 2018

The technological process of cheese making is a process of transforming milk
as a raw material into cheese and value adding. Small producers at registered
agricultural households (RAHs) use milk of good quality that they produced.
Also, they produce cheese by applying skills and experience as an
indispensable part of quality, in contrast to big dairy plants where milk
originating from a large number of producers is used, and furthermore the
production automation is applied. RAHs produce many traditional cow cheeses,
and more recently, goat and sheep cheese production is growing. Lisnati
cheese (rolled cheese), ?podliveni? cheese with or without spices, cream
cheese, brined cheese ?kriska?, smoked goat cheese, various types of
semi-hard and hard cheeses are products with added value, due to the good
milk quality, as well as the specific technological process. Cheese yield
contribute that profit is higher than in case when milk is sold to dairy
plant. The aim of this study was to monitor the technological processes of
the most important cheeses that are produced on RAHs in Vojvodina. Study is
shown that quality should be constantly improved in order to achieve
sustainability of these products on the market. When considering the
assortment and quality of cheeses on RAHs in Vojvodina, it can be said that
many of them have the characteristics of branding products. The impact of
adding value to cheeses and other dairy products is manifested through higher
primary milk production, employment and the livelihoods of people in the
countryside, as well as the economic prosperity of small family farms in
general.
Vitreoretinal interface changes after uncomplicated phacoemulsification
Authors: Zlatanovic Marko , Zivkovic Maja , Jaksic Vesna , Novak Sasa , Hristov Aleksandra , Zlatanovic Gordana , Sefic-Kasumovic Sanja , Radosavljevic Aleksandra , Jovanovic Svetlana
Published: January 2018

Introduction/Objective. The aim of this work was to examine the incidence of posterior vitreous detachment (PVD) after uncomplicated phacoemulsification, as well as the importance of optical coherence tomography (OCT) in detecting early changes on vitreoretinal interface. Methods. PVD was evaluated in 120 eyes of 120 patients aged between 50 and 70 years by the combination of OCT and ultrasonography immediately prior and one, six, and 12 month after the phacoemulsification cataract surgery with intraocular lens implantation. Results. The mean age was 57 ?} 8.8 years in female and 58.6 ?} 8.8 years in male subjects. The progress statuses were compared after cataract surgery at three time-points: after one, six, and 12 months. Significant progression of PVD in time was confirmed (?2 = 78.32, p < 0.001). The Wilcoxon test determined that after six months (p < 0.001) and 12 months (p < 0.001) the disease progression was statistically significant in comparison to measurements after one month. In addition, after 12 months, in relation to progression status established after six months, there was significant progression of the disease (p < 0.001). Conclusion. Vitreous body detachment after phacoemulsification surgery is common, and OCT plays a very important role in detecting initial changes on the vitreoretinal interface.
Hereditary entanglement – the significance of whakapapa and genealogical locatedness in Māori research: A researcher’s personal experience
Authors: Rangiwai Byron
Published: January 2018

This article explores the idea of hereditary entanglement as a concept for recognising whakapapa and the inseparability of genealogical locatedness within the context of Māori research. This article will look at my hereditary entanglement within the context of doctoral research that I completed at Auckland University of Technology. This article will argue that hereditary entanglement is not only unavoidable for Māori researchers who research aspects of their histories and heritage, but that Māori researchers with these connections are, in fact, the only people that can adequately carry out this type of research.
The potential for innovative development of modern cities LAW
Authors: Egoreichenko Aleksandra Borisovna ,   St. Petersburg State University
Published: January 2018

The research considers the potential for innovative urban environment development, defines the inno-vative development of cities. Modern cities remain the centers of innovative development and econom-ic growth; it gives relevance to the research topic. The study provides an overview of the theory of innovation, presents the most up-to-date ratings of innovative cities and examples of modern projects of innovative urban development in Russia (Smart Saint Petersburg) and abroad (PlanIT Valley, Konza Technology City). The paper shows how the innova-tive equipment of municipal economic systems cre-ates the favorable environment for the city’s infra-structure and its social and cultural development. The criteria of innovative urban development and the factors influencing the global leadership of smart cities are identified. Besides, the implementa-tion areas of the innovative urban potential (transport, culture, education, healthcare, public utility) are revealed.
CIE 150:2017 Guide on the Limitation of the Effects of Obtrusive Light from Outdoor Lighting Installations, 2nd Edition
Authors:   CIE TC 5-28
Published: January 2018

This report is a revision and update of CIE 150:2003 Guide on the Limitation of the Effects of Obtrusive Light from Outdoor Lighting Installations. The purpose of this Guide is to help formulate guidelines for assessing the environmental impacts of outdoor lighting and to give recommended limits for relevant lighting parameters to contain the obtrusive effects of outdoor lighting within tolerable levels. As the obtrusive effects of outdoor lighting are best controlled initially by appropriate design, the guidance given is primarily applicable to new installations; however, some advice is also provided on remedial measures which may be taken for existing installations.-\n-This Guide refers to the potentially adverse effects of outdoor lighting on both natural and man-made environments for people in most aspects of daily life, from residents, sightseers, transport users to environmentalists and astronomers. (Astronomers also see CIE 126-1997.)-\n-The daytime appearance of the lighting installation is important. The size and nature of the lighting support structures may be intrusive by day although this subject is not addressed in this Guide.-\n-The publication replaces CIE 150:2003 Guide on the Limitation of the Effects of Obtrusive Light from Outdoor Lighting Installations. Keywords: lighting design, exterior lighting, obtrusive light, residence lighting, spill light
Polimorfismos en genes de baja penetrancia como marcadores genéticos de riesgo de cáncer de mama familiar entre mujeres colombianas
Authors: REVISTAS SISTEMAS , Tróchez David , Solarte Melissa , Cortés Carolina , Cifuentes Laura , Barreto Guillermo
Published: January 2018

El cáncer de mama es la neoplasia femenina más frecuente a nivel mundial. Se estima que la mayoría de casos son esporádicos, pero entre el 10-15% de ellos tienen historia familiar positiva de la enfermedad. Esta predisposición familiar se ha asociado con mutaciones en genes involucrados en el sistema de detección y reparación de daños en el ADN; tales como los genes BRCA 1 y 2, las cuales se encuentran presentes en el 25% de los casos y en el 75% restante se propone la acción de alteraciones en genes de baja penetrancia.
Análisis de las abundancias atmosféricas en la estrella gigante roja HD 62968
Authors: REVISTAS SISTEMAS , Molina Ramón Eveiro , Rivera Hender
Published: January 2018

Se reporta un análisis detallado de las abundancias químicas en la atmósfera de la estrella HD 62698 que fue seleccionada en el catálogo PASTEL por su exceso infrarrojo. Se emplean espectros de alta resolución(R~12000) obtenidos de la librería ELODIE (OHP).
Determinación y comparación de microhongos del suelo de un bosque húmedo premontano en Dagua, Valle del Cauca
Authors: Mendoza A. Paola A. , Torres G. Celina
Published: January 2018

Con el propósito de conocer las variaciones en la microbiota fúngica, al perturbar un terreno, se comparó la diversidad, abundancia y riqueza de hongos filamentosos del suelo en dos situaciones (bosque intervenido y bosque no intervenido) en un bosque húmedo premontano (bh-PM), en el municipio de Dagua, Valle del Cauca. Se determinaron los microhongos presentes y se calculó la diversidad (Simpson), la abundancia y la riqueza. Se tomaron 30 muestras (15 en el área intervenida y 15 en el área no intervenida) durante doce meses. Para el proceso de aislamiento, se utilizaron diluciones, desde 10- 2 hasta 10-5 y se sembraron en PDA. Para la identificación, las muestras se montaron y se observaron en microscopio óptico.Se identificaron 17 géneros en cada zona (Intervenida y no intervenida) con 27 morfotipos para ambas áreas. Se realizó una ANOVA factorial en donde no se encontraron diferencias significativas en diversidad (p= 0.88), abundancia (p=0.28) y riqueza (p=0.47). Se hallaron especies únicas en cada área como el morfotipo Botryotrichum sp. el cual solo se encontró en el área intervenida. Así mismo, Penicillium sp2., Mortierella sp1 y Colletotrichum sp. se observaron únicamente en el área no intervenida, considerando estas Morfoespecies como propias del bh-PM.
Isolation of oligosaccharide fraction from wheat cell culture and determination of its monosaccharide composition
Authors: Murtazina A. S. , Bishimbaeyva N. K. , Mc Dougall G.
Published: January 2018

Oligosaccharides, being a part of plant cell wall, can be secreted to the intercellular space and perform «signaling» activity on plant tissues – high physiological activity in very low concentrations.Oligosaccharide (OS) fraction was obtained from extracellular liquid wheat cell culture by size exclusion chromatography. Monosaccharide composition of extracellular OS has been determined by HPLC Ionic chromatography. It was shown that extracellular OS contain glucose, xylose, arabinose, galactose, fructose and rhamnose monosaccharide residues.
Synthesis and study of physical-chemical properties of expanded graphite
Authors: Nyssanbayeva G. , Tursunbek S. , Kudaibergenov K. , Ongarbayev Ye. , Mansurov Z. , Lubchik S.
Published: January 2018

One a of the most urgent problems in the field of ecological status assessment is developing of a single integral approach to the problem of environmental quality and, in particular, of water as well as the evaluation criteria of their quality.In this study, natural graphite is converted to adsorbent, intended for the use in getting rid of oil stains. The microstructure and morphology of expanded graphite made of antitermal natural graphite were investigated by Raman spectroscopy and scanning electron microscope (SEM).
Innovative terminative process was discovered and investigated in the systems «graphite – reactantoxidant» – it is a direct oxidative conversion of graphite in TWG going through the sig formation of as unstable intermediate reactions thermolysis.
The study of graphite’s as sorbents of oil in Kazakh science and technology is very relevant and has will be used in future.
Terrestrial and solar magnetism’ influence to diphtheria pandemics
Authors: Gumarova L. , Cornelissen G.
Published: January 2018

The number of physicochemical factors of the environment is extremely high. The geophysical components of the environment are under the influence of cosmic forces. The sun, the moon, the planets and the stars are connected with the Earth by invisible bonds. Gravitation, radiation, electromagnetic fields and corpuscular ceilings of the Sun and stars are far from a complete list of the cosmic forces acting on the Earth. Changes in the activity of the Sun are reflected in the biosphere directly through photosynthesis of plants, and indirectly through changes in climatic conditions on the Earth, which affects various biological processes. One of the first scientists, who paid attention to the dependence of pandemics with solar cycles, was Alexander Chizhevsky.In this study, we perform a meta-analysis of statistical data on diphtheria, based on the data published by Chizhevsky in the 20th century. We here add for the association of terrestrial and solar magnetism with these infectious diseases that were common in the past, using nonlinear analysis, cosinor-analysis and cross-wavelet coherence. We showed the geographic differences hidden in Chizhevsky’s data on diphtheria. Wavelets of Wolf numbers and of the antipodal geomagnetic index show maxima corresponding to the anticipated ~11.7-year cycle, also seen from the spectra plotted vertically next to the color key. The numbers indicate the period length (in years) corresponding to local maxima in amplitudes; but the color code matters most. The wavelet also reveals the presence of an about 22.1-year component differing from the smaller about 19.7-year peaklet observed for Wolf numbers. Both these peaks are less prominent than the about 29.5-year peak found for diphtheria.
PENGEMBANGAN BAHAN AJAR PENDIDIKAN JASMANI OLAHRAGA KESEHATAN (PJOK) TERINTEGRASI DENGAN AL-ISLAM KEMUHAMMADIYAHAN BAHASA ARAB (ISMUBA) DI SD/MI MUHAMMADIYAH
Authors: Widodo Agung
Published: January 2018

SD/MI Muhammadiyah sebagai lembaga pendidikan Islam memiliki salahsatu ciri khusus yang menjadi keunggulan yaitu Al-Islam dan Kemuhammadiyahan (ISMUBA). Idealnya, nilai-nilai ISMUBA tersebut diimplementasikan ke dalam segala aspek kegiatan di sekolah muhammadiyah termasuk di dalam pembelajaran. Salahsatu implementasi dalam pembelajaran idealnya diwujudkan salahsatunya dalam bentuk bahan ajar. Penelitian ini bertujuan untuk: (1) merumuskan kebutuhan bahan ajar Pendidikan Jasmani Olahraga dan Kesehatan (PJOK) menurut guru di lingkungan pendidikan Muhammadiyah; dan (2) mengembangkan prototype menjadi bahan ajar PJOK yang terintegrasi dengan Al Islam, Kemuhammadiyah, dan Bahasa Arab (ISMUBA) di SD/MI Muhammadiyah.Metode penelitian yang digunakan dalam penelitian ini adalah penelitian dan pengembangan (Research and Development/R&D) untuk menghasilkan bahan ajar. Tahapan dalam metode ini terdiri atas tiga tahapan yaitu (1) tahap studi pendahuluan, yaitu studi literatur dan studi lapangan; (2) tahap pengembangan, meliputi: analisis bahan ajar, desain produk awal (prototype); dan (3) tahap evaluasi, yang terdiri dari validasi ahli dan uji lapangan untuk menguji kelayakan dan keefektifan bahan ajar PJOK terintegrasi ISMUBA di SD/MI Muhammadiyah. Penelitian ini sudah sampai pada tahap yang ketiga yaitu tahap evaluasi dengan dilakukannya uji kelayakan bahan ajar pada uji skala kecil. Akan tetapi, dikarenakan keterbatasan waktu uji keefektifan bahan ajar belum dilakukan.Hasil validasi ahli materi yang diperoleh dari penilaian yang dilakukan oleh ahli ISMUBA dan ahli pendidikan jasmani sekolah dasar terhadap draf bahan ajar yang dikembangkan secara keseluruhan diperoleh skor 81.5 dari skor maksimal 110. Setelah dihitung persentasenya penilaian dari ahli (validator) menunjuk pada angka 74,09%. Selanjutnya, berdasarkan hasi penilaian praktisi pada uji skala kecil diperoleh skor 80 dari skor maksimal 110. Setelah dihitung persentasenya, menunjuk pada angka 74,09%. Hal ini menunjukkan bahan ajar tematik integratif PJOK dengan ISMUBA di SD/MI Muhammadiyah dikategorikan sebagai bahan ajar yang baik/layak digunakan dalam pembelajaran.
Efficacy of Profilactic and Therapeutic Antibiotic in Congenital Hydrocephalus Shunt Infection
Authors: Imron Akhmad , Wiriadisastra Kahdar
Published: January 2018

Prophylactic dose antibiotic are indicated in patients having neurosurgical clean operations with implant surgery. The aim of this study is to evaluate the efficacy of prophylactic dose antibiotic in shunt infection. Between 1 October 2009 until 31 September 2011, 102 patients with congenital hydrocephalus who underwent VP shunt surgery. Fifty-one received profilactic antibiotic (ceftriaxone 50-75 mg/kgBW), 30-60 minutes before surgery until 5 days post-operative, and 51 patients received therapeutic antibiotic  (ceftriaxone 50-75 mg/kgBW), 30-60 minutes before surgery until 1 days post-operative. All patient were followed for 1-6 months to evaluate shunt infection. Collected data will be statistically analyzed. The study found that the rate of infection is 17,6% (9 patients of 51 patients) who received therapeutic antibiotic, and 17,6% (9 patients of 51 patients) who received profilactic antibiotic.There is not statistically significant between all group in shunt infection (p=1,000). Others risk factors significantly influence shunt infection are enlargement of the head (p=0,002), length of surgery (p=0,00327), time of surgery (p=0,00077) and nutrition status (p=0,01343). The results of this study indicate that profilactic antibiotic effective to prevent shunt infection in congenital hydrocephalus. Others risk factors significantly influence are enlargement of the head, length of surgery, time of surgery and nutrition status. Keywords:  antibiotic,  prophylactic, infection, VP shunt, congenital hydrocephalus
The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer
Authors: Wargasetia Teresa L.
Published: January 2018

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy
The Probiotic Effect towards Aspirin-induced Gastric Ulcer Healing Process as Measured by Mucous Thickness, Reepithelization, Gastric Glands Formation, and Angiogenesis in Animal Model
Authors: Lucretia Teresa , Achadiyani Achadiyani , Masria Sadeli
Published: January 2018

Gastric Ulcer is a common side effect of Non-Steroid Anti Inflammatory Drugs (NSAIDs) use such as Aspirin. Probiotic has many benefits especially for the alimentary system, but the effect on gastric ulcer have yet to be explored. In this research we aimed to find the probiotic effect on histological structure changes during aspirin induced gastric ulcer healing process in animal model. This was simple random sampling animal experimental laboratory, that divided Wistar Rats into two main groups. Both groups were induced with Aspirin (300mg/Kg BW) per oral, once daily for three consecutive days,and subsequently the test group were given probiotic suspension (cfu >108/gr) per oral, once daily, for 14 days. Each subgroups were sacrified serially at day 0, 3, 7, 14. The gaster were collected and processed for histology examination. Better histological structures were shown in the test group at day 14. MANOVA result showed probiotic's effect in enhancing histological structure changes during gastric ulcer healing process. Better histological structure changes were observed in mucus thickness; reepitelization, gastric glands formation, and angiogenesis process of the test group. As a conclusion, probiotic enhanced mucus thickness, reepitelization, glands remodelling, and angiogenesis in Aspirin induced gastric ulcer healing process in animal model. Key words: probiotic, gastric ulcer, histological structure, aspirin, healing process
A Quantum Mechanical Analysis of the Electronic Response of BN Nanocluster to Formaldehyde
Authors: Vahabi Vahid , Soleymanabadi Hamed
Published: January 2018

It has been previously demonstrated that the electronic properties of pristine BN nanotubes and graphene-like sheets are not sensitive toward presence of H2CO gas. Here, the adsorption of H2CO on the external surface of B12N12 nano-cage is studied using X3LYP and Minnesota density functional calculations. Three different adsorption behaviors were found including physisorption, chemisorption, and chemical functionalization. Gibbs free energy changes at room temperature and 1 atm pressure is in the range of -0.07 to -2.00 eV (X3LYP). The HOMO-LUMO energy gap of the cluster dramatically decreases after the H2CO chemisorption. Thus, B12N12 nanocluster may be used in gas sensor devices for H2CO detection.
Brefeldin-A: an Antiproliferative Metabolite of the Fungus Curvularia trifolii Collected from the Veracruz Coral Reef System, Mexico
Authors: Espinoza César , Couttolenc Alan , Fernández José J. , Norte Manuel , Plata Gabriela B. , Padrón José M. , Shnyreva Alla , Trigos Ángel
Published: January 2018

In this paper the isolation and structure analysis of three sterols and brefeldin-A from the mycelial extract of the liquid fermentation of fungus Curvularia trifolii isolated from the marine sponge Amphimedon compressa collected from the Coral Reef System of Veracruz is reported. This is the first report on the production of brefeldin-A by the fungus C. trifolii. The results on isolation biological activity support the importance of the conservation of the Mexican ecosystems of coral reefs as a source of microorganisms with a pharmaceutical potential.
Cytotoxic and Anti-inflammatory Constituents from Juncus effusus
Authors: Wei Ma , Feng Liu , Yue Zhang , Ning Li
Published: January 2018

A new sesquilignan effususin E (1) and a new long chain fatty enamide effususin F (2), together with eight known compounds were isolated from the medullae of Juncus effusus. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H and 13C NMR, COSY, HSQC, HMBC, and HRMS, while the struc-tures of the known compounds were deduced from comparison of their spectral data with those in the literature. The new compounds 1 and 2 were evaluated against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela, and MCF-7) by CCK-8 assay, but only 1 exhibited weak cytotoxic activity against SMMC-7721 with IC50 val-ue of 57.5 μM. Inhibitory effects of 1 and 2 on nitric oxide (NO) pro-duction in lipopolysaccharide-induced RAW264.7 macrophages were also evaluated, and they were found to exhibit good inhibitory activities with IC50 values of 8.59 and 13.73 μM, respectively.
Rapid Monitoring of Copper Over a Wide Concentration range by High-Sensitive Potentiometric Membrane Electrode Based on 1-cyano-1-piperidino-2(N- piperidino methyl)-cyclo hexane
Authors: Hajiaghababaei Leila , Borbor Iman , Najafpour Jamshid , Raouf Darvich Mohammad , Reza Ganjali Mohammad , Dehghan Fateme
Published: January 2018

n this paper, 1-cyano-1-piperidino-2(N- piperidino meth-yl)-cyclohexane was synthesized. The lowest-energy conformer of this molecule (Ligand) with axial and equatorial forms of cyanide toward cyclohexane and local minima corresponding to their complexes with various ions were obtained using Monte Carlo procedure by Molecular Mechanics with MMFF94 method. The calculated results of the Gibbs free energy of the reaction using density functional theory (DFT) show that the thermodynamic reactivity of complexation of copper ion with studied ligand is the best. Finally, a selective and sensitive copper-ion selective liquid membrane electrode for potentiometric monitoring of ultra-trace amounts of Cu2+ was prepared by using 1-cyano-1-piperid-ino-2(N- piperidino methyl)-cyclohexane as an excellent ionophore. This electrode exhibits a Nernstian response for Cu2+ ions over a con-centration range (1.5 × 10-2 to 1.0 × 10-8 mol L-1) with a slope of 28.4±0.4 mV per decade. The limit of detection of the sensor is 6.3 × 10-9 mol L-1. The sensor has a relatively fast response time (<10 s) and a useful working pH range of 5.0–8.5. Interference of some cations was also evaluated. The practical utility of the Cu2+ ion sensor has been demonstrated by using it as an indicator electrode in potentiomet-ric titration of Cu2+ with EDTA and for direct determination of Cu2+ in well water samples.
One Drug for Multiple Targets: A Computational Perspective
Authors: Méndez-Lucio Oscar , Naveja J. Jesús , Vite-Caritino Hugo , Prieto-Martínez Fernando Daniel , Medina-Franco José Luis
Published: January 2018

This review discusses the concept of polypharmacology in drug discovery and development. The relationship between polyphar-macology and polypharmacy, drug repurposing, combination of drugs and in vivo testing are discussed. Modern applications of polypharma-cology and polypharmacy in epigenetic and antiviral drug development are described as examples. A survey of modern methodologies to design and develop multiple-target ligands is presented with a special focus on computational-based methods. These approaches include, but are not limited to, target fishing, proteochemometric modeling, data mining of side effects of drugs, and computer-aided drug repurposing.
Determination of Acidity Constants, Partition Coefficients between Water and 1-Octanol, and Deprotonation Route of 4-tert-buthyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol and 4-hydroxy-3,5-bis(morpholin-1-ylmethyl)benzonitrile; Compounds with Antihypert
Authors: Ibarra-Escutia Agustin , Rojas-Hernández Alberto , Galano Annia , Ángeles Enrique , Martínez-Mendoza Diana , Moya-Hernández Rosario
Published: January 2018

The pKa values for two compounds (LQM303 and LQM314) with antihypertensive properties were determined by UV spectroscopy (T = 310.15 K and I = 0.15 M) and by Capillary Zone Electrophoresis (T = 310.15 K and I = 0.05 M), using the program SQUAD. The partition coefficients (logP) between water and 1-octanol have also been determined experimentally, demonstrating that both compounds fulfill with the physicochemical parameter logP ≤ 5 of Lipinski´s rules. Calculations on the framework of Density Functional Theory have allowed identifying the functional group related to each pKa for each compound.
Synthesis and Characterization of Three New di-n-butyl [bis (alkyl-aminopropionic acid)]tin (IV)
Authors: Nieto-Alvarez David Aaron , Zamudio-Rivera Luis S. , Hernández-Altamirano Raúl , Mena-Cervantes Violeta Y. , Barba Victor , Flores-Sandoval César
Published: January 2018

The synthesis of novel di-n-butyl [bis (alkyl-aminopropionic acid)]tin (IV) (alkyl = octyl, dodecyl, octadecyl) 2a-2c is reported. The complexes were characterized by 1H, 13C, 119Sn NMR, IR, MS and elemental analyses. For compound 2a the 119Sn NMR showed the presence of five signals suggesting the existence of a mixture of five hexa–coordinated species in equilibrium, two trans (I, II) and three cis (III, IV, V). In contrast, the compounds 2b and 2c present only unique hexa–coordinated specie.
Hydrate Equilibrium Modelling with the Cubic two-state Equation of State
Authors: Galicia-Andrés Edgar , Medeiros Milton
Published: January 2018

A combination of the cubic two-state equation of state and the van der Waals–Platteeuw model was employed for the description of the hydrate formation thermodynamics, with and without inhibitors. The model parameters were determined from the properties of pure compounds and from phase equilibrium data of binary gas–water and water–inhibitor mixtures. With these parameters, predictions were performed for multicomponent gas–water–inhibitor systems. For single-gas hydrates, the average absolute deviations found for equilibrium pressure did not exceed 8%, whereas for multi-gas hydrates, these deviations were 23% maximum. The proposed model produced good predictions in the presence of inhibitors (methanol, ethanol, ethylene glycol and triethylene glycol), with increasing deviations at higher concentrations of inhibitors.
Chalcopyrite Leaching in Acidic Chloride Solution without Sulphates
Authors: Recalde Chiluiza Eduardo Luis Recalde Chiluiza Luis , Navarro Donoso Patricio
Published: January 2018

Chalcopyrite leaching in acidic chloride solution without sulphates. The effect of dissolved oxygen and ferrous/ferric/cupric ions in solution on the leaching behavior of chalcopyrite and the phenomenology of the passivating layer formation on the chalcopyrite surface in an aqueous acidic chlorinated medium with dissolved oxygen and without sulphate are studied. The research was performed using pure chalcopyrite samples with particle sizes of +45 to -75 microns (-200+325 mesh). It was found that the formation of hydrogen sulfide (H2S) at room temperature and atmospheric pressure is a possible precursor of passivating species that prevent chalcopyrite dissolution.
Paired Electrochemical Processes: Overview, Systematization, Selection Criteria, Design Strategies, and Projection
Authors: G. Ibanez Jorge , Frontana-Uribe Bernardo A. , Vasquez-Medrano Rubén
Published: January 2018

In most commercial electrochemical processes, only one of the two sides of the cell produces a desirable reaction, whereas the complementary reaction at the other side simply avoids interference with the target process and/or offers fast kinetics as not to limit it. An overview of several possible paired reaction schemes and their advantages is given, accompanied with specific thermodynamic and kinetic selection criteria, cell and reaction design strategies, and examples from the organic, inorganic, and environmental areas. The unnecessary nomenclature dispersion in this field (e.g., combined, concurrent, conjugate, convergent, coupled, divergent, dual, duet, linear, paired, parallel, simultaneous and synchronous electrochemical processes) is revised and a simple, consistent classification, as well as a homogeneous schematization system, is proposed.
Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer
Authors: Gutierrez-Cano Jessica R. , Nahide Pradip D. , Ramadoss Velayudham , Satkar Yuvraj , Ortiz-Alvarado Rafael , Alba-Betancourt Clara , Mendoza-Macías Claudia L. , Solorio-Alvarado César R.
Published: January 2018

A series of new 3,4-diarylmaleimides were synthesized in an optimized and efficient lineal sequence of three steps, starting from commercial maleimide. The biological evaluation of these compounds as enhancers (activity modulators) in the co-administration with doxorubicin treatment in breast cancer cells directly obtained from a patient, were essayed. The cancerous tissue BT026-512N was provided by the National Institute of Cancerology (INCAN) of México. This tissue was obtained by biopsy from a patient diagnosed with stage IIB ductal breast cancer. The results obtained in the assays, show decreased cell viability on the cultured cells for all of the maleimides synthesized in combinatorial administration with doxorubicin. The highest mortality effect was determined for maleimides 9 and 29 increased in close to three times the effect compared with treatment using only doxorubicin. Based on previous functionalized maleimides core reports and Molinspiration chemoinformatic analysis, these results could possibly point out to the Pg-p glycoprotein as bio-molecular action target of maleimides by kinase phosphorylation-inhibition, although more experimental data is necessary.
Transformation of Ferulic Acid and Vanillin by Isolated Placentas of Capsicum chinense and Capsicum annuum
Authors: Vázquez-Flota Felipe , Monforte-González Miriam , Miranda-Ham María de Lourdes , Castro-Concha Lizbeth A.
Published: January 2018

Isolated placentas of the highly pungent Capsicum chinense (Habanero pepper), readily transformed ferulic acid and vanillin into capsaicinoids, whereas those from a mild C. annuum cultivar showed a low transformation rate of ferulic acid, in comparison to vanillin. Cell cultures from both species showed low levels of capsaicinoids and exposure to both intermediaries did not increase their amounts. Results suggest that the transformation of ferulic acid to vanillin is a limiting step in capsaicinoids synthesis in C. annuum, but not in C. chinense and thus, may account for its higher pungency.
GPU Algorithm for the Scaled Opposite-Spin (SOS) MP2 Energy Evaluation
Authors: Martínez-Martínez Luis Ángel , Amador-Bedolla Carlos
Published: January 2018

The most computationally intensive part of the SOS-MP2 algorithm for the calculation of the correlation energy [1], as executed in Q-Chem, is implemented for use in a graphical processing unit (GPU). Our approach adds new routines to the library initially developed by Aspuru-Guzik and co-workers [2], aiming at maximization of bandwidth and performance, by taking advantage of the asynchronous CPU-GPU communication capability of modern GPUs. These changes permit an almost six-fold acceleration in the correlation energy calculation of linear alkanes. This was achieved employing a NVIDIA Tesla K40C (Kepler) GPU and the Compute Unified Device Architecture (CUDA).
Tonantzitlolone A and other cytotoxic constituents of Sapium macrocarpum (Euphorbiaceae)
Authors: Novillo Fernando , Rosero Verónica , Chávez María Isabel , Hernández-Ortega Simón , Martínez Esteban M. , Delgado Guillermo
Published: January 2018

Sapium macrocarpum (Euphorbiaceae) is a tropical tree located mainly in the southern part of Mexico and in Central America, and it is used in the Mayan traditional medicine for the treatment of several skin diseases. The dichloromethane-MeOH extract of the aerial parts displayed cytotoxic activity against certain cancer cell lines. Lupeol (1), lupenone (2), sitostenone (3), β-sitosterol (4), stigmasterol (5), sitosteryl β-D-glucopyranoside (6) and the rare diterpene tonantzitlolone A (7) were characterized from this extract. The structural analysis allowed the 1H NMR reassignments for H-12α and H-12β, and for H-13α and H-13β of tonantzitlolone A (7). The cytotoxic activity of compounds 1-3, 6 and 7 was evaluated against selected cancer cell lines. Compounds 3, 6 and 7 displayed clear activity against K562 (leukemia). This is the first report on the chemical constituents of S. macrocarpum, and points out that this species is an additional source of tonantzitlolone A. Compound 7 has only been reported previously from species of the Stillingia, Sebastiania and Sapium genera, which belong to the Hippomaninae subtribe of the family Euphorbiaceae.