bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of life and deglutition after total laryngectomy
Authors: Oliveira Jabson Herber Profiro de , Régis Renata Milena Freitas Lima , Lima Leilane Maria de , Araújo Ana Maria Bezerra de , Balata Patrícia Maria Mendes , Cunha Daniele Andrade da , Silva Hilton Justino da , Pernambuco Leandro de Araújo
Published: October 2012

Introduction: Total laryngectomy creates deglutition disorders and causes a decrease in quality of life

Aim: To describe the impact of swallowing and quality of life of patients after total laryngectomy.

Method: A case series study. Patients completed a Swallowing and Quality of Life questionnaire composed of 44 questions assessing 11 domains related to quality of life (burden, eating duration, eating desire, frequency of symptoms, food selection, communication, fear, mental health, social functioning, sleep, and fatigue). The analysis was performed using descriptive statistics, including measures of central tendency and variability.

Results: The sample comprised 15 patients who underwent total laryngectomy and adjuvant radiotherapy. Of these, 66.7% classified their health as good and 73% reported no restrictions on food consistency. The domains “communication” and “fear” represented severe impact and “eating duration” represented moderate impact on quality of life. The items with lower scores were: longer time to eat than others (domain “eating duration”), cough and cough to remove the liquid or food of the mouth when they are stopped (domain “symptom frequency”), difficulties in understanding (domain “communication”) and fear of choking and having pneumonia (domain “fear”).

Conclusion: After total laryngectomy, patients report that swallowing issues have moderate to severe impact in “communication,” “fear,” and “eating duration” domains.
Limits on quality of life in communication after total laryngectomy
Authors: Pernambuco Leandro de Araújo , Balata Patrícia Maria Mendes , Santos Veridiana da Silva , de Lima Leilane Maria , de Souza Síntia Ribeiro , da Silva Hilton Justino , Chaves Adriana Di Donato
Published: October 2012

Introduction: Among people affected by cancer, the impairment of quality of life of people affected by cancer can cause have devastating effects. The self-image of patients after post-laryngectomyzed patients may be find themselves compromised, affecting the quality of life in this population.

Objective: To characterize quality of life in related to communication in people who have undergone went total laryngectomy surgery.

Methods: This is an observational study, with a cross-sectional and descriptive series.

Design of series study. The sample were comprised 15 patients interviewed the period from January to February of 2011. We used the Quality Protocol for Life Communication in Post-laryngectomy adapted from Bertocello (2004); which this questionnaire contains 55 questions. The protocol was organized from the nature of using responses classified as positive and negative aspects, proposals in with respect to five 5 communication domains: family relationships, social relationships, personal analysis; morphofunctional aspect, and use of writing. To promote and guarantee the autonomy of the respondents, was examiners made use of used assistive technology with the Visual Response Scale.

Results: The responses that total laryngectomy compromises the quality of life in communication amounted to 463 occurrences (65.7%), and that who responses suggesting good quality of life were represented with amounted to 242 occurrences (34.3%), from a total of 705 occurrencesresponses. From Among the five 5 Communication domains, four 4 had percentages of above 63% for occurrences of negative content for impact on communication. Appearance Morphofunctional appearance gave the had the highest percentage of negative content, amounting to 77.3% of cases.

Conclusions: The results showed important limitations of a personal and social nature due to poor communication with their peers. Thus, there is a need for multidisciplinary interventions that aim to minimize the entrapment of negative impact on these people communication among these patients.
Prevalence of noise-induced hearing loss in drivers
Authors: Otowiz Vanessa Guioto , Lopes Patrícia Monteiro de Barros , Lauris José Roberto Pereira , Santos Cibele Carméllo , Lopes Andréa Cintra
Published: October 2012

Introduction: Work-related hearing loss is one of the most common occupational illness progresses over the years of noise exposure associated with the work environment, may cause damage to undertake physical activity, the individual's physiological and mental besides causing hearing damage irreversible interfering with communication and quality of life. With high prevalence of male evaluates which is the second leading cause of hearing loss. Since there is no medical treatment for this type of hearing loss, it is evident the importance of preventive and conferences aimed at preserving hearing and health as a whole.

Objective: To assess the prevalence of hearing loss in audiometry admission of drivers.

Methods: Retrospective study. By 76 charts of professional drivers in leased transport companies. We analyzed data from specific interview and pure tone audiometry.

Results: The prevalence of abnormal tests was 22.36% with the lowest thresholds for tritonal average of 3,000, 4,000 and 6,000 Hz. The higher the age, the higher thresholds.

Conclusion: This study has highlighted the occurrence of hearing in the absence of complaints. Considering that PAIR is preventable, justifies the importance of coordinated and multidisciplinary involving not only health teams and safety, but also the institutions involved in preserving the health of workers, as the team SESMET, unions or prosecutors.
Severe complication of posterior nasal packing: Case Report
Authors: Pinto José Antônio , Cintra Pedro Paulo Vivacqua da Cunha , Sônego Thiago Branco , Leal Carolina de Farias Aires , Artico Marina Spadari , Soares Josemar dos Santos
Published: October 2012

Introduction: Severe Epistaxis is common in patients with head trauma, especially when associated with multiple fractures of the face and skull base. Several methods of controlling bleeding that can be imposed. The anterior nasal tapenade associated with posterior Foley catheter is one of the most widespread, and the universal availability of necessary materials or their apparent ease of execution.

Methods: Case report on control of severe epistaxis after severe TBI, with posterior nasal packing by Foley catheter and control tomography showing multiple fractures of the skull base and penetration of the probe into the brain parenchyma.

Conclusion: This is a rare but possible complication in the treatment of severe nose bleeds associated with fracture of the skull base. This brief report highlights risks related to the method and suggests some care to prevent complications related through a brief literature review.
Recurrence of atypical fibroxanthoma. Diagnosis and treatment
Authors: Mattiola Lyzandro , Mattiola Giovani , Mattiola Sandra Zucchi de Moraes , Moura Carlos Eduardo , Kirschnick Alexandre , Mattiola Leandro Ricardo
Published: October 2012

Introduction: The soft tissue sarcomas (SPM) accounts for only 1% of malignant tumors of the adult population. The SPM is the most frequent malignant fibrous histiocytoma (MFH) that exhibits behavior characterized by the tendency to invasion of adjacent tissue and metastatic spread early. One of its variants is the atypical fibroxanthoma (FA).

Objective: To describe a case of probable recurrence of AF underwent surgical treatment and presentation of a literature review.

Case report: Patient female, 63 years, presenting with a mass in the face about four inches and a history of prior resection of the lesion in the same topography. The patient underwent surgical resection with a diagnosis of AF.

Conclusion: The FA is a rare tumor histological diagnosis difficult. The correct histological diagnosis and patient follow-up are essential.
Predição da biodiversidade em ambientes antropizados, através da análise e classificação de imagens de alta resolução do satélite RapidEye. DOI: 10.7902/ecb.v2i1.28
Authors: Jardim Antônio Freire , Caixeta Paulo Ricardo Correa , Gomes Luciano Martins , Lopes Leonardo José
Published: October 2012

A biodiversidade de uma região é um fator intrinsecamente relacionado à saúde do ecossistema que a engloba. No intuito de avaliar a cobertura florestal da região abrangida pelo Núcleo Operacional Carangola – uma unidade administrativa do Instituto Estadual de Florestas (IEF) – e consequentemente sua biodiversidade, buscou-se levantar informações espaciais que pudessem ser correlacionadas aos princípios fundamentais do conceito de biodiversidade: variedades de espécies, grau de fragmentação, conectividade dos ecossistemas naturais e a influencia destes fatores na integridade biológica do ambiente. Para tanto, foi aplicado um método supervisionado de classificação automática em imagens orbitais de alta resolução, o Bhattacharya. Indicadores de qualidade, Kappa e Exatidão Global, apresentaram resultados 0,69 e 0,73, respectivamente, considerados bons. Constatou-se que os remanescentes de ecossistemas naturais encontram-se reduzidos e desconectados, principalmente em meio a pastagens degradadas. Isso permite afirmar que, consideradas algumas limitações, a metodologia tem grande potencial no monitoramento contínuo da paisagem frente às transformações antrópicas.
Lixo e coleta seletiva sob o olhar de adultos e crianças. DOI: 10.7902/ecb.v2i1.30
Authors: Oliveira Michelle Morais , Silva Francielih Dorneles , Palmeira Paula Angélica , Pereira Marlon Correa
Published: October 2012

A questão do lixo urbano é hoje um dos maiores desafios a serem resolvidos pela sociedade moderna. O modelo de desenvolvimento e de cultura atuais geraram um estilo de vida cujo padrão se baseia nos excessos de consumo e de desperdício. Nesse sentido, buscou-se analisar as representações sociais de crianças e de adultos sobre o lixo, por meio de questionários, para planejamento de ações de educação ambiental. Pode-se concluir que as representações sociais das crianças e adultos são bem semelhantes. Os dois grupos vêem o cuidado com o lixo voltado apenas para a limpeza do ambiente e para a coleta realizada pela prefeitura. Atividades de educação ambiental voltadas à questão do lixo são importantes para que as pessoas ampliem seus conhecimentos sobre a temática e se conscientizem quanto ao que podem fazer para mudar a realidade em que vivem, despertando nelas a vontade de melhorar  seu comportamento.
Observer‐based adaptive neural control of uncertain MIMO nonlinear systems with unknown control direction
Authors: Arefi Mohammad M. , Jahed‐Motlagh Mohammad R.
Published: October 2012

This paper investigates adaptive neural network output feedback control for a class of uncertain multi‐input multi‐output (MIMO) nonlinear systems with an unknown sign of control gain matrix. Because the system states are not required to be available for measurement, an observer is designed to estimate the system states. In order to deal with the unknown sign of control gain matrix, the Nussbaum‐type function is utilized. By using neural network, we approximated the unknown nonlinear functions and perfectly avoided the controller singularity problem. The stability of the closed‐loop system is analyzed by using Lyapunov method. Theoretical results are illustrated through a simulation example. Copyright © 2012 John Wiley & Sons, Ltd.
Patterns of survival in lymphoplasmacytic lymphoma/waldenström macroglobulinemia: A population‐based study of 1,555 patients diagnosed in Sweden from 1980 to 2005
Authors: Kristinsson Sigurdur Y. , Eloranta Sandra , Dickman Paul W. , Andersson Therese M‐L. , Turesson Ingemar , Landgren Ola , Björkholm Magnus
Published: October 2012

Clinical management of lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) has changed considerably over recent years, reflected in the use of new therapeutic agents (purine analogs, monoclonal antibodies, thalidomide‐ and bortezomib‐based therapies). No population‐based studies and few randomized trials have been performed to assess survival in newly diagnosed LPL/WM. We performed a large population‐based study in Sweden including 1,555 LPL/WM patients diagnosed from 1980 to 2005. Relative survival ratios (RSRs) and excess mortality rate ratios (EMRR) were computed as measures of survival. Survival of LPL/WM patients has improved significantly (P = 0.007) over time with 5‐year RSR = 0.57 (95% confidence interval [CI] 0.46–0.68), 0.65 (0.57–0.73), 0.74 (0.68–0.80), 0.72 (0.66–0.77), and 0.78 (0.71–0.85) for patients diagnosed during the calendar periods 1980–1985, 1986–1990, 1991–1995, 1996–2000, and 2001–2005, respectively. Improvement in 1‐ and 5‐year relative survival was found in all age groups and for LPL and WM separately. Patients with WM had lower excess mortality compared to LPL (EMRR = 0.38; 95% CI 0.30–0.48). Older age at diagnosis was associated with a poorer survival (P < 0.001). Taken together, we found a significant improvement in survival in LPL/WM over time. Despite this progress, new effective agents with a more favourable toxicity profile are needed to further improve survival in LPL/WM, especially in the elderly. Am. J. Hematol. 2013. © 2012 Wiley Periodicals, Inc.
Improvement of SAPO‐34 fine layer formation on ceramic and steel supports by applying uniform‐size synthesized seed particles
Authors: Jabbari Zeinab , Fatemi Shohreh , Davoodpour Mahdi
Published: October 2012

The synthesis of fine seed particles and secondary growth of SilicoAluminoPhosphate‐34 (SAPO‐34) thin films on porous tubular α‐Al2O3 and stainless steel supports have been implemented with focus on the synthesis parameters and conditions by hydrothermal method. The type of organic structure directing agents —morpholine and tetraethyl ammonium hydroxide or their mixture, agitation method of the raw materials, aging time and crystallization conditions were studied for appropriate formation of the uniform and small size SAPO‐34 particles. Formation of SAPO‐34 crystalline phase was confirmed by the X‐ray diffraction (XRD) analyses and scanning electron microscopy (SEM) images. The mean size and particle size distribution were calculated from the images of SEM. The range of the particles prepared by different procedures varied from 0.7 ± 0.12 to 2.0 ± 0.7 µm. The finest and most uniform‐size seeds were employed in layer formation by secondary growth on the surface of α‐alumina and stainless steel substrates. The resulted thicknesses of the SAPO‐34 top‐layer for secondary growth ranged from 1.4 to 3.7 µm, whereas they varied in a broad range of 1.8–10.1 µm when in situ crystallization was applied. It was revealed that applying secondary growth with the most uniform synthesized seeds leads to formation of the appropriate fine and uniform layer on both types of the supports.

Ultrasonic waves for homogenizing the starting materials deserved a promoting way for faster, simpler and lower cost for synthesis of SAPO‐34 seeds, and performing external mechanical agitation during crystallization process achieved homogeneous particles. © 2012 Curtin University of Technology and John Wiley & Sons, Ltd.
Interaction of nafion ionomers toward various solvents
Authors: Santhosh Kumar K. S. , Vijayalakshmi K. P. , Sivanath Sangeetha , Jayalatha T. , Mohanty Surajeet , Shaneeth M.
Published: October 2012

Interactions of Nafion (Naf) ionomer with water, aqueous ethanol (EA), aqueous isopropyl alcohol (IPA), and aqueous ammonia were investigated by attenuated total reflectance (ATR)–infrared (IR) spectroscopy, differential scanning calorimetry, thermogravimetric analysis, and computational modeling studies. Microstructural features by ATR–IR revealed the existence of hydrophilic interaction of Naf with all solvents. The Naf membranes formed hydrogen bonds with water, aqueous EA, and IPA. The incorporation of solvents on the Naf matrix impaired the crystallinity, which was highest in the case of IPA. Of all the microsolvated structures of Naf investigated, the formation of H3O+ ions was evident; in addition, H5O2+ ions appeared in the alcohol–water mixture, and NH4+ ions were observed in the water–ammonia mixture along with a direct ion pair with the SO3− group in Naf. Theoretical studies based on computational modeling disclosed that the interchain distance increased with enhanced interactions (hydrophobic interactions in particular), and this was in good agreement with the highest swelling ratio of the Naf membrane in aqueous IPA and EA solvents. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Poly(propylene) composite with hybrid nanofiller: Dynamic properties
Authors: Sarlin Juha , Immonen Kirsi
Published: October 2012

Mechanical, impact, and relaxation properties of in situ synthesized carbon nanotubes‐polyaniline (CNT‐PANi) hybrid nanoparticle‐filled poly(propylene) (PP) composites with or without an amphiphilic dispersing agent were investigated using tensile testing, notched Charpy impact testing, and dynamical mechanical testing methods. The reference material was MWCNT filled PP composite. Ethyl gallate (EG) was the dispersing agent which realizes high conductivity in PP composites with hybrid filler. Measured properties showed quite similar behavior of CNT‐PANi hybrid and neat CNT filled composites. Addition of 20% EG in PP did not cause essential differences compared to the neat PP. When the dispersing agent was added in filler containing PP composites, remarkable effects were observed, especially in PP‐hybrid composites. Mechanically, these materials had improved tensile properties, but they were brittle compared to the materials without dispersing agent. Dynamic mechanical analysis showed improvement in storage modulus, and in loss modulus the α transition was well observable. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Dielectric properties of highly filled thermoplastics for printed circuit boards
Authors: Apeldorn Thomas , Keilholz C. , Wolff‐Fabris F. , Altstädt V.
Published: October 2012

In this study, highly filled high‐temperature thermoplastics (polyethersulfone [PES], polyphenylensulfide, polyetherimide [PEI], and polyetheretherketone [PEEK]) are used as insulating substrate for printed circuit boards (PCBs). Talc has been added to the thermoplastics to adjust their coefficient of thermal expansion (CTE) to the CTE of the copper circuits, thus reducing the possibility of failure of the PCB owing to thermal stress. The dielectric properties of the substrates were analyzed between 10 MHz and 1 GHz, depending on filler fraction and water absorption. An increase of filler fraction resulted in an increase of dielectric constant ε′. As expected, the absorption of water molecules led to an increase of both tan δ and ε′. Moreover, the combination of filler and absorbed water resulted in a strong increase of the dielectric loss factor at low frequencies. Finally, theoretical approaches with fitting parameters could be employed to precisely describe the measured properties between 0.8 and 1 GHz. This study shows that most of the materials investigated here, namely highly filled PPS, PEI, and PEEK, are suitable for high‐frequency PCB applications. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Complex magnetic field exposure system for in vitro experiments at intermediate frequencies
Authors: Lodato Rossella , Merla Caterina , Pinto Rosanna , Mancini Sergio , Lopresto Vanni , Lovisolo Giorgio A.
Published: October 2012

In occupational environments, an increasing number of electromagnetic sources emitting complex magnetic field waveforms in the range of intermediate frequencies is present, requiring an accurate exposure risk assessment with both in vitro and in vivo experiments. In this article, an in vitro exposure system able to generate complex magnetic flux density B‐fields, reproducing signals from actual intermediate frequency sources such as magnetic resonance imaging (MRI) scanners, for instance, is developed and validated. The system consists of a magnetic field generation system and an exposure apparatus realized with a couple of square coils. A wide homogeneity (99.9%) volume of 210 × 210 × 110 mm3 was obtained within the coils, with the possibility of simultaneous exposure of a large number of standard Petri dishes. The system is able to process any numerical input sequence through a filtering technique aimed at compensating the coils' impedance effect. The B‐field, measured in proximity to a 1.5 T MRI bore during a typical examination, was excellently reproduced (cross‐correlation index of 0.99). Thus, it confirms the ability of the proposed setup to accurately simulate complex waveforms in the intermediate frequency band. Suitable field levels were also attained. Moreover, a dosimetry index based on the weighted‐peak method was evaluated considering the induced E‐field on a Petri dish exposed to the reproduced complex B‐field. The weighted‐peak index was equal to 0.028 for the induced E‐field, indicating an exposure level compliant with the basic restrictions of the International Commission on Non‐Ionizing Radiation Protection. Bioelectromagnetics 34:211–219, 2013. © 2012 Wiley Periodicals, Inc.
Determination of aliskiren in human serum quantities by HPLC–tandem mass spectrometry appropriate for pediatric trials
Authors: Burckhardt Bjoern B. , Ramusovic Sergej , Tins Jutta , Laeer Stephanie
Published: October 2012

The orally active direct renin inhibitor aliskiren is approved for the treatment of essential hypertension in adults. Analytical methods utilized in clinical studies on efficacy and safety have not been fully described in the literature but need a large sample volume ranging from 200 to 700 μL, rendering them unsuitable particularly for pediatric applications. In the assay presented only 100 μL of serum is needed for mixed‐mode solid‐phase extraction. The chromatographic separation was performed on XselectTM C18 CSH columns with mobile phase consisting of methanol–water–formic acid (75:25:0.005, v/v/v) and a flow rate of 0.4 mL/min. Running in positive electrospray ionization and multiple reaction monitoring the mass spectrometer was set to analyze precursor ion 552.2 m/z [M + H]+ to product ion 436.2 m/z during a total run time of 5 min. The method covers a linear calibration range of 0.146–1200 ng/mL. Intra‐run and inter‐run precisions were 0.4–7.2 and 0.6–12.9%. Mean recovery was at least 89%. Selectivity, accuracy and stability results comply with current European Medicines Agency and Food and Drug Administration guidelines. This successfully validated LC‐MS/MS method with a wide linear calibration range requiring small serum amounts is suitable for pharmacokinetic investigations of aliskiren in pediatrics, adults and the elderly. Copyright © 2012 John Wiley & Sons, Ltd.
Anticipatory behavior in virtual universe, application to a virtual juggler
Authors: Buche C. , De Loor P.
Published: October 2012

To be believable, virtual entities must be equipped with the ability to anticipate, that is, to predict the behavior of other entities and the subsequent consequences on the environment. For that purpose, we propose an original approach where the entity possesses an autonomous world of simulation within simulation, in which it can simulate itself (with its own model of behavior) and simulate the environment (with the representation of the behaviors of the other entities). This principle is illustrated by the development of an artificial juggler in 3D. In this application, the juggler predicts the motion of the balls in the air and uses its predictions to coordinate its own behavior to continue to juggle.Copyright © 2012 John Wiley & Sons, Ltd.
DNA‐Directed Growth of Pd Nanocrystals on Carbon Nanotubes towards Efficient Oxygen Reduction Reactions
Authors: Zhang Lian Ying , Guo Chun Xian , Cui Zhiming , Guo Jun , Dong Zhili , Li Chang Ming
Published: October 2012

Unique DNA‐promoted Pd nanocrystals on carbon nanotubes (Pd/DNA–CNTs) are synthesized for the first time, in which through its regularly arranged PO43− groups on the sugar–phosphate backbone, DNA directs the growth of ultrasmall Pd nanocrytals with an average size of 3.4 nm uniformly distributed on CNTs. The Pd/DNA–CNT catalyst shows much more efficient electrocatalytic activity towards oxygen reduction reaction (ORR) with a much more positive onset potential, higher catalytic current density and better stability than other Pd‐based catalysts including Pd nanocrystals on carbon nanotubes (Pd/CNTs) without the use of DNA and commercial Pd/C catalyst. In addition, the Pd/DNA–CNTs catalyst provides high methanol tolerance. The high electrocatalytic performance is mainly contributed by the ultrasmall Pd nanocrystal particles grown directed by DNA to enhance the mass transport rate and to improve the utilization of the Pd catalyst. This work may demonstrate a universal approach to fabricate other superior metal nanocrystal catalysts with DNA promotion for broad applications in energy systems and sensing devices.
Study on 1,3,5‐Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species
Authors: Kunishima Munetaka , Ujigawa Takae , Nagaoka Yoshie , Kawachi Chiho , Hioki Kazuhito , Shiro Motoo
Published: October 2012

The reaction of 2‐chloro‐4,6‐dimethoxy‐1,3,5‐triazine (CDMT) with various nitrogen‐containing compounds, particularly tertiary amines (tert‐amines), has been studied for the preparation of 2‐(4,6‐dimethoxy‐1,3,5‐triazinyl)trialkylammonium salts [DMT‐Am(s)]. DMT‐Ams derived from aliphatic tert‐amines exhibited activity for the dehydrocondensation between a carboxylic acid and an amine to form an amide in a model reaction. Based on a conformational analysis of DMT‐Ams and tert‐amines by NMR and X‐ray diffraction methods, we concluded that a β‐alkyl group maintained in a gauche relationship with the nitrogen lone pair of tert‐amines significantly hinders the approach of CDMT to the nitrogen. Thus, trimethylamine and quinuclidine without such alkyl groups readily react with CDMT whereas triethylamine, possessing two or three such gauche β‐alkyl groups in the stable conformations, does not react at all. The theory of “gauche β‐alkyl group effect” proposed here provides useful guidelines for the preparation of DMT‐Ams possessing various tertiary amine moieties. An investigation of the dehydrocondensation activity of tert‐amines in a CDMT/tert‐amine system that involves in situ generation of DMT‐Am, showed that the gauche effect of the β‐alkyl group becomes quite pronounced; the yield of the amide decreases significantly with tert‐amines possessing an unavoidable gauche β‐alkyl group. Thus, the tert‐amine/CDMT systems are useful for judging whether tert‐amines can readily react with CDMT without isolation of DMT‐Ams.
ChemInform Abstract: Phase Transition and Conduction Mechanism of Rare Earth Based Tungsten‐Bronze Compounds.
Authors: Parida B. N. , Das Piyush R. , Padhee R. , Choudhary R. N. P.
Published: October 2012

Polycrystalline materials Li2Pb2Ln2W2Ti4 Nb4O30 (Ln: Y, Eu) are synthesized by solid state reaction of Li2CO3, TiO2, Nb2O5, WO3, PbO, and Ln2O3 (alumina crucible, 1100 °C, 4 h).
ChemInform Abstract: A Cationic Antimonite Chain Templated by Sulfate: [Sb6O74+] [(SO42‐)2].
Authors: Fei Honghan , Han Cari S. , Oliver Scott R. J.
Published: October 2012

Colorless needlelike single crystals of the title compound are hydrothermally synthesized from aqueous solutions of Sb(OAc)3 and H2SO4 (autoclave, 150 °C, 72 h, 87% yield).
ChemInform Abstract: Nanoscale Hemispheres in Novel Mixed‐Valent Uranyl Chromate(V,VI), (C3NH10)10 [(UO2)13(Cr125+O42) (Cr6+O4)6(H2O)6] (H2O)6.
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Petrunin Anatoly A. , Kayukov Roman A. , Krivovichev Sergey V.
Published: October 2012

Single crystals of the new title compound are hydrothermally obtained from aqueous solutions containing UO2(NO3)2, CrO3, and isopropylamine (autoclave, 100 °C, 8 d) followed by slow evaporation in air (21 d, 21% yield).
ChemInform Abstract: Highly Enantioselective Chlorination of β‐Keto Esters and Subsequent SN2 Displacement of Tertiary Chlorides: A Flexible Method for the Construction of Quaternary Stereogenic Centers.
Authors: Shibatomi Kazutaka , Soga Yoshinori , Narayama Akira , Fujisawa Ikuhide , Iwasa Seiji
Published: October 2012

The reaction occurs in the presence of the new ligands (I) affording α‐chlorinated products with high enantioselectivity.
ChemInform Abstract: Tungsten‐Catalyzed Heterocycloisomerization Approach to 4,5‐Dihydro‐benzo[b]furans and ‐indoles.
Authors: Fisher Ethan L. , Wilkerson‐Hill Sidney M. , Sarpong Richmond
Published: October 2012

Resulting benzofurans and indoles are versatile intermediates which can be used for further functionalizations.
ChemInform Abstract: A Facile and Economical Procedure for the Synthesis of Maleimide Derivatives Using an Acidic Ionic Liquid as a Catalyst.
Authors: Li Kai , Yuan Chao , Zheng Shijun , Fang Qiang
Published: October 2012

A room temperature ionic liquid is applied as recyclable catalyst for the dehydrative cyclization of maleamic acid amides to N‐substituted maleimides.
ChemInform Abstract: Minimisation of E‐Factor in the Synthesis of N‐Hydroxylamines: The Role of Silver(I)‐Based Coordination Polymers.
Authors: Sheykhan Mehdi , Ranjbar Zohreh Rashidi , Morsali Ali , Heydari Akbar
Published: October 2012

Nano‐rods of silver complexed N,N′‐bis(4‐pyridyl formamide)‐1,4‐benzene bearing different anions are synthesized and applied as highly efficient catalysts in the partial oxidation of primary amines (I) and (III) with urea hydrogen peroxide to afford the corresponding hydroxylamines (II) and (IV).
ChemInform Abstract: Asymmetric Hydrogenation of N‐Alkyl and N‐Aryl Ketimines Using Chiral Cationic Ru(diamine) Complexes as Catalysts: The Counteranion and Solvent Effects, and Substrate Scope.
Authors: Chen Fei , Ding Ziyuan , He Yanmei , Qin Jie , Wang Tianli , Fan Qing‐Hua
Published: October 2012

Various complexes bearing different counterions are investigated and (I) is demonstrated to be the most effective one.
ChemInform Abstract: SBA‐15‐Functionalized Palladium Complex Partially Confined with Ionic Liquid: An Efficient and Reusable Catalyst System for Aqueous‐Phase Suzuki Reaction.
Authors: Karimi Babak , Zamani Asghar
Published: October 2012

A very efficient and reusable (four times) catalyst is successfully applied to the Suzuki—Miyaura coupling reaction of the compounds (I) including aryl chlorides and heteroaryl halides.
ChemInform Abstract: Palladium‐Catalyzed Suzuki Cross‐Coupling Reaction Using a Fluorous NHC Ligand.
Authors: Wan Li , Yu Hong , Cai Chun
Published: October 2012

The utilization of N‐heterocyclic carbene palladium complex immobilized on fluorous silica gel through fluorous‐fluorous interactions in the Suzuki cross‐coupling reaction is described.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Cu‐Catalyzed [3 + 3] Cycloaddition of Propargyl Esters with Cyclic Enamines Toward Chiral Bicyclo[n.3.1] Frameworks.
Authors: Zhang Cheng , Hu Xin‐Hu , Wang Ya‐Hui , Zheng Zhuo , Xu Jie , Hu Xiang‐Ping
Published: October 2012

For the first time the mild, simple, and efficient title reaction, which can be used for a broad substrate scope, is presented.
ChemInform Abstract: Highly Selective Reactions of C60Cl6 with Thiols for the Synthesis of Functionalized [60]Fullerene Derivatives.
Authors: Troshin Pavel A. , et al. et al.
Published: October 2012

The potassium salts of compounds (IIIe) and (IIIf) show interesting activity against a broad panel of DNA and RNA viruses, like HIV‐1or influenza AH3N2 virus subtype.
ChemInform Abstract: Synthesis, Characterization and Bioactivity of Polysubstituted 1‐(4‐(1H‐Pyrrol‐1‐yl)phenyl)‐1H‐pyrrole Derivatives.
Authors: Elassar Abdel‐Zaher A.
Published: October 2012

A variety of polysubstituted bispyrroles are synthesized by reaction of 1,4‐bis[(2‐oxopropyl)amino]benzene (III) with dimethylformamide dimethylacetal or active methylene compounds.
ChemInform Abstract: Diastereodivergent Synthesis of 3‐Spirocyclopropyl‐2‐oxindoles Through Direct Enantioselective Cyclopropanation of Oxindoles.
Authors: Dou Xiaowei , Lu Yixin
Published: October 2012

The direct organocatalytic asymmetric cyclopropanation reaction of oxindoles by employing oxindoles as C1 synthon and bromonitroolefins as a convenient C2 synthon is described.
ChemInform Abstract: New Approach to the Synthesis of 1,3‐Dioxolanes
Authors: Vol'eva V. B. , Belostotskaya I. S. , Malkova A. V. , Komissarova N. L. , Kurkovskaya L. N. , Usachev S. V. , Makarov G. G.
Published: October 2012

using transketalization reactions of ketal (III)
ChemInform Abstract: A Novel and Practical Synthesis of Rimonabant Hydrochloride.
Authors: Fang Zheng , Yang Zhao , Xu Jia‐Feng , Guo Kai , Wei Ping
Published: October 2012

In comparison to the known method, this new strategy is more competitive and features simplified work‐up processes.
ChemInform Abstract: One‐Pot Synthesis of 1,2,3‐Triazoles from Boronic Acids in Water Using Cu(II)—β‐Cyclodextrin Complex as a Nanocatalyst.
Authors: Kaboudin Babak , Abedi Yaghoub , Yokomatsu Tsutomu
Published: October 2012

The efficient, simple, and rapid method, which uses a readily available and simple nanocatalyst in air without any additives, for the synthesis of the title compounds is reported and follows a click cyclization reaction.
ChemInform Abstract: C3‐Symmetric Trisimidazoline‐Catalyzed Enantioselective Bromolactonization of Internal Alkenoic Acids.
Authors: Murai Kenichi , Nakamura Akira , Matsushita Tomoyo , Shimura Masato , Fujioka Hiromichi
Published: October 2012

The catalytic, enantioselective bromolactonization of internal alkenoic acids is developed by using trisimidazoline as chiral catalyst.
ChemInform Abstract: Double Intramolecular 1,3‐Dipolar Cycloaddition of Diazido‐Terminal Dialkyne: Synthesis of a New Bis(1,2,3‐triazolo‐1,4‐oxazine) (IV).
Authors: Mekni Nejib Husein , Baklouti Ahmed
Published: October 2012

The title compound (IV) shows moderate antibacterial activity against Enterococcus feacium, however, it is inactive against E.
ChemInform Abstract: New Farnesyltransferase Inhibitors in the Phenothiazine Series.
Authors: Belei Dalila , Dumea Carmen , Samson Alexandrina , Farce Amaury , Dubois Joelle , Bicu Elena , Ghinet Alina
Published: October 2012

Phenothiazine derivatives of type (III) and (IV) are prepared using click chemistry approach.
ChemInform Abstract: Versatile Gold Catalyzed Transglycosidation at Ambient Temperature.
Authors: Kayastha Abhijeet K. , Hotha Srinivas
Published: October 2012

Mechanistic investigation reveal that the leaving group which is superior compared to simple propargyl glycosyl donors simply extrudes out as 1‐ethynylcyclohexanol.
ChemInform Abstract: A Novel Franchetine Type Norditerpenoid Isolated from the Roots of Aconitum carmichaeli Debx. with Potential Analgesic Activity and Less Toxicity
Authors: Wang Dao‐Ping , Lou Hua‐Yong , Huang Lan , Hao Xiao‐Jiang , Liang Guang‐Yi , Yang Zai‐Chang , Pan Wei‐Dong
Published: October 2012

isolation and structure of the new diterpenoid alkaloid, guiwuline (I), which exhibits potential analgesic activity
ChemInform Abstract: Approaches to Iodinated Derivatives of Vanillin and Isovanillin.
Authors: Nammalwar Baskar , Bunce Richard A. , Berlin K. Darrell , Bourne Christina R. , Bourne Philip C. , Barrow Esther W. , Barrow William W.
Published: October 2012

Previously unknown 5‐iodovanillin ethers like (VI) and (VIII) are prepared by a three‐step strategy consisting of ether cleavage, regioselective methylation and subsequent O‐alkylation.
ChemInform Abstract: Heusler Alloys: Experimental Approach Towards Room‐Temperature Half‐Metallicity
Authors: Hirohata A. , Otani Y.
Published: October 2012

Review: 125 refs.
ChemInform Abstract: Effects of Amorphization on Magnetic Properties in Bilayers and Films
Authors: Benyoussef A. , El Kenz A.
Published: October 2012

Review: 137 refs.
ChemInform Abstract: Noble‐Metal Nanocrystals with Concave Surfaces: Synthesis and Applications
Authors: Zhang Hui , Jin Mingshang , Xia Younan
Published: October 2012

Review: 81 refs.
ChemInform Abstract: Nano‐Architecture and Material Designs for Water Splitting Photoelectrodes
Authors: Chen Hao Ming , Chen Chih Kai , Liu Ru‐Shi , Zhang Lei , Zhang Jiujun , Wilkinson David P.
Published: October 2012

Review: 72 refs.
ChemInform Abstract: Electrochemical Properties of CdSe and CdTe Quantum Dots
Authors: Amelia Matteo , Lincheneau Christophe , Silvi Serena , Credi Alberto
Published: October 2012

Review: 101 refs.
ChemInform Abstract: Recent Advances in Transition Metal—Catalyzed O‐Glycosylations
Authors: Li Xiaohua , Zhu Jianglong
Published: October 2012

Review: 122 refs.
ChemInform Abstract: Photoaffinity Probes for Studying Carbohydrate Biology
Authors: Yu Seok‐Ho , Wands Amberlyn M. , Kohler Jennifer J.
Published: October 2012

Review: 55 refs.
ChemInform Abstract: Syntheses of Fawcettimine‐Type Lycopodium Alkaloids Utilizing the Pauson—Khand Reaction
Authors: Nakayama Atsushi , Kitajima Mariko , Takayama Hiromitsu
Published: October 2012

Review: 70 refs.
ChemInform Abstract: Diazole, Triazole, and Tetrazole N‐Oxides
Authors: Begtrup Mikael
Published: October 2012

Review: ca. 200 refs.
ChemInform Abstract: “Common Synthetic Scaffolds” in the Synthesis of Structurally Diverse Natural Products
Authors: Anagnostaki Elissavet E. , Zografos Alexandros L.
Published: October 2012

Review: 41 refs.
ChemInform Abstract: Synthesis of Isoindoles and Related Iso‐Condensed Heteroaromatic Pyrroles
Authors: Heugebaert Thomas S. A. , Roman Bart I. , Stevens Christian V.
Published: October 2012

Review: 107 refs.
ChemInform Abstract: The Thriving Chemistry of Ketenimines
Authors: Lu Ping , Wang Yanguang
Published: October 2012

Review: ca. 100 refs.
ChemInform Abstract: Surface Chemistry to Minimize Fouling from Blood‐Based Fluids
Authors: Blaszykowski Christophe , Sheikh Sonia , Thompson Michael
Published: October 2012

Review: 126 refs.
ChemInform Abstract: Catalysis by Metallic Nanoparticles in Aqueous Solution: Model Reactions
Authors: Herves Pablo , Perez‐Lorenzo Moises , Liz‐Marzan Luis M. , Dzubiella Joachim , Lu Yan , Ballauff Matthias
Published: October 2012

Review: 60 refs.
ChemInform Abstract: Microbial Metalloproteomes Explored Using MIRAGE
Authors: Sevcenco Ana‐Maria , Hagen Wilfred R. , Hagedoorn Peter‐Leon
Published: October 2012

Review: 37 refs.
A study of foam granulation and wet granulation in a twin screw extruder
Authors: Weatherley S. , Thompson M.R. , Sheskey P.J.
Published: October 2012

This research investigated a new technique known as foam granulation for the continuous manufacturing of pharmaceuticals by a twin screw extruder. Six grades of hypromellose were compared as binders in the trials, using two addition methods: foam injection by auxiliary side stuffer feeder and liquid injection directly into the extruder. The produced granules were tested for particle size, Carr compressibility index and characteristic fracture strength. It was found that granulation using foam injection improved powder lubrication inside the extruder and wetting uniformity of the lactose, as well as produced granules having lower Carr indices. © 2012 Canadian Society for Chemical Engineering
Structural Exploration of (3S,6S)‐6‐Benzhydryl‐N‐benzyltetrahydro‐2H‐pyran‐3‐amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants
Authors: Santra Soumava , Gogoi Sanjib , Gopishetty Bhaskar , Antonio Tamara , Zhen Juan , Reith Maarten E. A. , Dutta Aloke K.
Published: October 2012

To further explore the basic structural motifs (3S,6S)‐6‐benzhydryl‐N‐benzyltetrahydro‐2H‐pyran‐3‐amine and (2S,4R,5R)‐2‐benzhydryl‐5‐(benzylamino)tetrahydro‐2H‐pyran‐4‐ol, developed by our research group, for monoamine transport inhibition, we designed and synthesized various structurally altered analogues. The new compounds were tested for their affinities for the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET) in rat brain by measuring their capacity to inhibit the uptake of [3H]DA, [3H]5‐HT, and [3H]NE, respectively. Our results point to novel compounds with a TUI, DNRI, SNRI, or SSRI profile. Among the TUIs, compound 2 g exhibited a balanced potency for all three monoamine transporters (Ki: 60, 79, and 70.3 nM for DAT, SERT, and NET, respectively). In the rat forced swim test, compound 2 g produced a significant decrease in immobility in drug‐treated rats relative to vehicle, indicating a potential antidepressant property.
Conductive Photoswitchable Vanadium Oxide Nanopaper based on Bacterial Cellulose
Authors: Gutierrez Junkal , Fernandes Susana C. M. , Mondragon Iñaki , Tercjak Agnieszka
Published: October 2012

A bacterial cellulose mat was used as a template for the fabrication of conductive photoswitchable hybrid nanopaper by the incorporation of sol‐gel synthesized vanadium nanoparticles. The resulting nanopaper, prepared through a green pathway, was able to photoinduce a reversible color change. Conductive properties at the nano‐ and macroscales were confirmed by electrostatic force microscopy and semiconductor analysis measurements, respectively.
A gain/efficiency‐enhanced bidirectional switched‐capacitor DC‐DC converter
Authors: Chang Yuen‐Haw , Wu Kun‐Wei
Published: October 2012

A closed‐loop gain/efficiency‐enhanced bidirectional switched‐capacitor converter (BSCC) is proposed by combining an adaptive‐conversion‐ratio (ACR) phase generator and pulse‐width‐modulation (PWM) controller for bidirectional step‐up/down DC‐DC conversion and regulation. For realizing gain‐enhanced, the power part consists of onemc‐stage cell and onenc‐stage cell in cascade between low‐voltage (LV) and high‐voltage (HV) sides to boost HV voltage intomc × nctimes voltage of LV source at most, or convert LV voltage into 1/(mc × nc) times voltage of HV source at most. For realizing efficiency‐enhanced, the ACR idea with adapting stage numberm, nis built in the phase generator to obtain a suitable step‐up/down gain:m × nor 1/(m × n) (m = 1, 2, …, mc,n = 1, 2, …, nc). Further, the output regulation and robustness to source/loading variation can be enhanced by PWM on the LV/HV sides. Some theoretical analysis and control design are included as: modeling, steady‐state analysis, conversion ratio, efficiency, capacitance selection, and control design. Finally, the performance of this scheme is verified experimentally on a BSCC prototype, and all results are illustrated to show the efficacy of this scheme. Copyright © 2012 John Wiley & Sons, Ltd.
Extension of the variational equation to analog/digital circuits: numerical and experimental validation
Authors: Bizzarri Federico , Brambilla Angelo , Storti Gajani Giancarlo
Published: October 2012

Conventional shooting methods cannot be used to determine the steady‐state solution of circuits whose model is characterised by a vector field exhibiting zero order discontinuities. In the analysis of circuits working on a stable limit cycle, this limitation prevents the use of methods that exploit Floquet theory to compute the variational model and thus the properties of the fundamental matrix and, for example, phase noise in oscillators. In this paper, we use an improved shooting method that solves this drawback by resorting to saltation matrices and show how this method makes possible the correct computation of the first left eigenfunction (known as ppv) of the fundamental matrix. ppvs are a key aspect in determining phase noise. The results obtained through numerical simulations are compared with measurements on a relaxation oscillator serving as a simple but significant comparison vehicle. Copyright © 2012 John Wiley & Sons, Ltd.
Magnetic Structures of HoCoO3 and TbCoO3
Authors: Muñoz Angel , Martínez‐Lope María J. , Alonso Jose A. , Fernández‐Díaz María T.
Published: October 2012

The magnetic behavior of HoCoO3 and TbCoO3 has been studied from magnetic measurements and neutron diffraction experiments performed on polycrystalline samples. The magnetic measurements indicate that the Co3+ ions exhibit a low‐spin electronic configuration t2g6eg0 with S = 0 below room temperature. The neutron diffraction data show that HoCoO3 and TbCoO3 order with an antiferromagnetic structure below TN = 3 and 3.6 K, respectively. The magnetic structure for HoCoO3 and TbCoO3 are given by the basis vectors (Ax,0,Cz) and (Cx,0,Az), respectively. Therefore, the magnetic moments are in the (010) plane. At T = 1.5 K, the ordered magnetic moments of Ho3+ and Tb3+ ions are 6.48(4) and 7.86(4) μB, respectively.
Essential role of β‐human 8‐oxoguanine DNA glycosylase 1 in mitochondrial oxidative DNA repair
Authors: Su Yu‐Hung , Lee Yen‐Ling , Chen Sung‐Fang , Lee Yun‐Ping , Hsieh Yi‐Hsuan , Tsai Jui‐He , Hsu Jye‐Lin , Tian Wei‐Ting , Huang Wenya
Published: October 2012

8‐Oxoguanine (8‐OG) is the major mutagenic base lesion in DNA caused by reactive oxygen species (ROS) and accumulates in both nuclear and mitochondrial DNA (mtDNA). In humans, 8‐OG is primarily removed by human 8‐OG DNA glycosylase 1 (hOGG1) through the base excision repair (BER) pathway. There are two major hOGG1 isoforms, designated α‐ and β‐hOGG1, generated by alternative splicing, and they have distinct subcellular localization: cell nuclei and mitochondria, respectively. Using yeast two‐hybrid screening assays, we found that β‐ but not α‐hOGG1 directly interacts with the mitochondrial protein NADH:ubiquinone oxidoreductase 1 beta subcomplex 10 (NDUFB10), an integral factor in Complex 1 on the mitochondrial inner membrane. Using coimmunoprecipitation and immunofluorescence studies, we found that this interaction was greatly increased by hydrogen peroxide‐induced oxidative stress, suggesting that β‐ but not α‐hOGG1 is localized in the mitochondrial inner membrane. Analyses of nuclear and mtDNA damage showed that the β‐ but not α‐ hogg1 knockdown (KD) cells were severely defective in mitochondrial BER, indicating an essential requirement of β‐hOGG1 for mtDNA repair. β‐hogg1 KD cells were also found to be mildly deficient in Complex I activity, suggesting that β‐hOGG1 is an accessory factor for the mitochondrial integral function for ATP synthesis. In summary, our findings define β‐hOGG1 as an important factor for mitochondrial BER and as an accessory factor in the mitochondrial Complex I function. Mol. Mutagen. 2013. © 2012 Wiley Periodicals, Inc.
Fast inversion of a flexible regression model for multivariate pollen counts data
Authors: Salter‐Townshend Michael , Haslett John
Published: October 2012

We introduce a rich class of models π(Y | C,θ) for multivariate constrained, zero‐inflated counts data. We use new methodology for fast Bayesian inference on unobservedθgiven matched training dataand propose a new algorithm for fast inversion to π(C | Y). Such models arise in palaeoclimate reconstruction, whereYrepresents vector of counts of a proxy such as pollen andCrepresents climate. Subsequently,is a vector of counts in a sample reflecting ancient pollen rain and thus ancient climate (the palaeoclimate). The methodology applies in principle to palaeoclimate reconstruction from other proxy types (e.g. chironomids, diatoms, testate amoebae). Furthermore, the generic issue—the statistical inversion of a multivariate relationship—is found in many areas of application (e.g. clustering, supervised classification, medical imaging, oil shale modelling). The contribution of the paper is the application of a Nested‐Dirichlet–Multinomial model in conjunction with models for zero inflation and non‐parametric response surface modelling. We present the models and the tools to perform fast Bayesian inference on the forward problem and inversion, by using integrated nested Laplace approximations. We demonstrate the increase in precision associated with including more climate proxies and the increase in error associated with doing this naïvely. Copyright © 2012 John Wiley & Sons, Ltd.