bluuebunny/crossref_metadata_2025 huggingface dataset:
No Impact of Functional Connectivity of the Motor System on the Resting Motor Threshold: A Replication Study
Authors: Engelhardt Melina , Komnenić Darko , Roth Fabia , Kawelke Leona , Finke Carsten , Picht Thomas
Published: March 2021

The physiological mechanisms of corticospinal excitability and factors influencing its measurement with transcranial magnetic stimulation are still poorly understood. A recent study reported an impact of functional connectivity (FC) between the primary motor cortex (M1) and the dorsal premotor cortex (PMd) on the resting motor threshold (RMT) of the dominant hemisphere. We aimed to replicate these findings in a larger sample of 38 healthy right-handed subjects with data from both hemispheres. Resting-state FC was assessed between the M1 and fivea prioridefined motor-relevant regions on each hemisphere as well as interhemispherically between both primary motor cortices. Following the procedure by the original authors, we included age, cortical gray matter volume, and coil-to-cortex distance (CCD) as further predictors in the analysis. We report replication models for the dominant hemisphere as well as an extension to data from both hemispheres and support the results with Bayes factors. FC between the M1 and the PMd did not explain the variability in the RMT, and we obtained moderate evidence for the absence of this effect. In contrast, CCD could be confirmed as an important predictor with strong evidence. These findings contradict the previously proposed effect, thus questioning the notion of the PMd playing a major role in modifying corticospinal excitability.
Machine Learning Driven Profiling of Cerebrospinal Fluid Core Biomarkers in Alzheimer’s Disease and Other Neurological Disorders
Authors: Bellomo Giovanni , Indaco Antonio , Chiasserini Davide , Maderna Emanuela , Paolini Paoletti Federico , Gaetani Lorenzo , Paciotti Silvia , Petricciuolo Maya , Tagliavini Fabrizio , Giaccone Giorgio , Parnetti Lucilla , Di Fede Giuseppe
Published: March 2021

Amyloid-beta (Aβ) 42/40 ratio, tau phosphorylated at threonine-181 (p-tau), and total-tau (t-tau) are considered core biomarkers for the diagnosis of Alzheimer’s disease (AD). The use of fully automated biomarker assays has been shown to reduce the intra- and inter-laboratory variability, which is a critical factor when defining cut-off values. The calculation of cut-off values is often influenced by the composition of AD and control groups. Indeed, the clinically defined AD group may include patients affected by other forms of dementia, while the control group is often very heterogeneous due to the inclusion of subjects diagnosed with other neurological diseases (OND). In this context, unsupervised machine learning approaches may overcome these issues providing unbiased cut-off values and data-driven patient stratification according to the sole distribution of biomarkers. In this work, we took advantage of the reproducibility of automated determination of the CSF core AD biomarkers to compare two large cohorts of patients diagnosed with different neurological disorders and enrolled in two centers with established expertise in AD biomarkers. We applied an unsupervised Gaussian mixture model clustering algorithm and found that our large series of patients could be classified in six clusters according to their CSF biomarker profile, some presenting a typical AD-like profile and some a non-AD profile. By considering the frequencies of clinically defined OND and AD subjects in clusters, we subsequently computed cluster-based cut-off values for Aβ42/Aβ40, p-tau, and t-tau. This approach promises to be useful for large-scale biomarker studies aimed at providing efficient biochemical phenotyping of neurological diseases.
CXCL5 Has Potential to Be a Marker for Hepatocellular Carcinoma Prognosis and Was Correlating With Immune Infiltrates
Authors: Nie Yuan , Jiang Mei-chun , Liu Cong , Liu Qi , Zhu Xuan
Published: March 2021

Backgrounds

Tumor microenvironment (TME) plays a crucial role in the initiation and progression of Hepatocellular Carcinoma (HCC), especially immune infiltrates. However, there is still a challenge in understanding the modulation of the immune and stromal components in TME, especially TME related genes.

Methods

The proportion of tumor-infiltrating immune cells (TICs) and the immune and stromal scores in 374 HCC patients from The Cancer Genome Atlas (TCGA) database were determined using CIBERSORT and ESTIMATE computational methods. The final screened genes were confirmed by the PPI network and univariate Cox regression of the differentially expressed genes based on different immune or stromal scores. The correlation between the expression levels of the final gene interactions and the clinical characteristics was based on TCGA database and local hospital data. Gene set enrichment analysis (GSEA) and the effect of CXCL5 expression on TICs were conducted.

Results

There were correlations between the expression of CXCL5 and survival of HCC patients and TMN classification both in TCGA database and local hospital data. The immune-related activities were enriched in the high-expression group; however, the metabolic pathways were enriched in the low-expression group. The result of CIBERSORT analyzing had indicated that CXCL5 expression were correlated with the proportion of NK cells activated, macrophages M0, Mast cells resting, Neutrophils.

Conclusions

CXCL5 was a potential prognostic marker for HCC and provides clues regarding immune infiltrates, which offers extra insight for therapeutics of HCC, however, more independent cohorts and functional experiments of CXCL5 are warranted.
Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes
Authors: Wang Wei , Wu Qianqian , Wang Ziheng , Ren Shiqi , Shen Hanyu , Shi Wenyu , Xu Yunzhao
Published: March 2021

Ovarian cancer (OV) has become the most lethal gynecological cancer. However, its treatment methods and staging system are far from ideal. In the present study, taking the advantage of large-scale public cohorts, we extracted a list of immune-related prognostic genes that differentially expressed in tumor and normal ovarian tissues. Importantly, an individualized immune-related gene based prognostic model (IPM) for OV patients were developed. Furthermore, we validated our IPM in Gene Expression Omnibus (GEO) repository and compared the immune landscape and pathways between high-risk and low-risk groups. The results of our study can serve as an important model to identify the immune subset of patients and has potential for use in immune therapeutic selection and patient management.
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways
Authors: Gao Lanyang , Zhu Danli , Wang Qin , Bao Zheng , Yin Shigang , Qiang Huiyan , Wieland Heinrich , Zhang Jinyue , Teichmann Alexander , Jia Jing
Published: March 2021

The ubiquitin-specific protease 7 (USP7), as a deubiquitinating enzyme, plays an important role in tumor progression by various mechanisms and serves as a potential therapeutic target. However, the functional role of USP7 in melanoma remains elusive. Here, we found that USP7 is overexpressed in human melanoma by tissue microarray. We performed TMT-based quantitative proteomic analysis to evaluate the A375 human melanoma cells treated with siRNA of USP7. Our data revealed specific proteins as well as multiple pathways and processes that are impacted by USP7. We found that the phosphatidylinositol-3-kinases/Akt (PI3K-Akt), forkhead box O (FOXO), and AMP-activated protein kinase (AMPK) signaling pathways may be closely related to USP7 expression in melanoma. Moreover, knockdown of USP7 in A375 cells, particularly USP7 knockout using CRISPR-Cas9, verified that USP7 regulates cell proliferation in vivo and in vitro. The results showed that inhibition of USP7 increases expression of the AMPK beta (PRKAB1), caspase 7(CASP7), and protein phosphatase 2 subunit B R3 isoform (PPP2R3A), while attenuating expression of C subunit of vacuolar ATPase (ATP6V0C), and peroxisomal biogenesis factor 11 beta (PEX11B). In summary, these findings reveal an important role of USP7 in regulating melanoma progression via PI3K/Akt/FOXO and AMPK signaling pathways and implicate USP7 as an attractive anticancer target for melanoma.
Eosinophils Are More Strongly Relevant to Allergic Sensitization Than Basophils in Pediatric Adenotonsillar Hypertrophy
Authors: Zou Juanjuan , Yang Yan , Fu Qiang , Liu Huayang , Zhang Chao , Liu Lili , Wang Yan , Li Yanzhong
Published: March 2021

The relationship between eosinophils/basophils and allergic sensitization is not clear in pediatric adenotonsillar hypertrophy (ATH). The objective of this study is to investigate the relationship between eosinophil/basophil counts and peripheral specific IgE levels, and identify the common allergens in children with ATH. We initially screened 1,031 consecutive children who underwent adenotonsillectomy in our department from June 2018 to June 2019, and finally included 676 children. The eosinophil count, basophil count, and levels of specific IgE were collected. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient. Logistic regression analyses were performed to evaluate the odds ratios (ORs) for atopy after controlling for age, sex, vitamin D, BMI, and visiting season. Both the eosinophil and basophil counts in atopic participants were significantly higher compared to non-atopic participants. The eosinophil count correlated with the levels of IgE specific to all allergens, and eosinophilia was independently associated with all tested atopy allergens other than atopy to dander after multivariate adjustment. Additionally, the basophil count correlated with the IgE levels specific to A. alternate and food mix, and basophilia was still significantly associated with atopy to food mix after multivariable adjustment. Furthermore, among allergic participants, D. farinae was the most prevalent allergen, followed by food mix, D. pteronyssinus, and A. alternata. In conclusion, eosinophils were more relevant to allergic sensitization than basophils, with eosinophils being significantly associated with all tested atopy allergens apart from dander, and basophils being associated with atopy to food mix. Furthermore, D. farinae was the most prevalent allergen and may be indicative of desensitization therapy.
The Controversy Persists: Is There a Qualification Criterion to Utilize Inhaled Nitric Oxide in Pre-term Newborns?
Authors: Vieira Frederico , Makoni Marjorie , Szyld Edgardo , Sekar Krishnamurthy
Published: March 2021

Inhaled nitric oxide (iNO) use in premature newborns remains controversial among clinicians. In 2014, the American Academy of Pediatrics, Committee on Fetus and Newborn released a statement that the available data do not support routine iNO use in pre-term newborns. Despite the absence of significant benefits, 2016 California data showed that clinicians continue to utilize iNO in pre-term infants. With studies as recent as January 2017, the Cochrane review confirmed no major advantages of iNO in pre-term newborns. Still, it recognized that a subset of pre-term infants with pulmonary hypertension (PHTN) had not been separately investigated. Furthermore, recent non-randomized controlled trials have suggested that iNO may benefit specific subgroups of pre-term newborns, especially those with PHTN, prolonged rupture of membranes, and antenatal steroid exposure. Those pre-term infants who showed a clinical response to iNO had increased survival without disability. These findings underscore the need for future studies in pre-term newborns with hypoxemic respiratory failure and PHTN. This review will discuss the rationale for using iNO, controversies regarding the diagnosis of PHTN, and additional novel approaches of iNO treatment in perinatal asphyxia and neonatal resuscitation in the pre-term population < 34 weeks gestation.
A Multinetwork and Machine Learning Examination of Structure and Content in the United States Code
Authors: Carlson Keith , Dadgostari Faraz , Livermore Michael A. , Rockmore Daniel N.
Published: March 2021

This paper introduces a novel linked structure-content representation of federal statutory law in the United States and analyzes and quantifies its structure using tools and concepts drawn from network analysis and complexity studies. The organizational component of our representation is based on the explicit hierarchical organization within the United States Code (USC) as well an embedded cross-reference citation network. We couple this structure with a layer of content-based similarity derived from the application of a “topic model” to the USC. The resulting representation is the first that explicitly models the USC as a “multinetwork” or “multilayered network” incorporating hierarchical structure, cross-references, and content. We report several novel descriptive statistics of this multinetwork. These include the results of this first application of the machine learning technique of topic modeling to the USC as well as multiple measures articulating the relationships between the organizational and content network layers. We find a high degree of assortativity of “titles” (the highest level hierarchy within the USC) with related topics. We also present a link prediction task and show that machine learning techniques are able to recover information about structure from content. Success in this prediction task has a natural interpretation as indicating a form of mutual information. We connect the relational findings between organization and content to a measure of “ease of search” in this large hyperlinked document that has implications for the ways in which the structure of the USC supports (or doesn’t support) broad useful access to the law. The measures developed in this paper have the potential to enable comparative work in the study of statutory networks that ranges across time and geography.
A Motivational Mechanism Framework for Teachers' Online Informal Learning and Innovation During the COVID-19 Pandemic
Authors: Yu Haiqin , Zhang Jian , Zou Ruomeng
Published: March 2021

Online informal learning (IL) spreads quickly in the COVID-19 Pandemic. Studies have predicted that both online and workplace IL have potential value to individual and organization development, whereas the study on its link with innovation remains scarce. IL is an individualized learning pattern different from formal learning, and its functioning mechanism on innovation will deepen our understanding of the relationship between learning and innovation. Self-efficacy and autonomous motivation are considered as two streams of motivational mediating mechanisms to innovation. However, previous studies have proceeded largely in separation from each other. Researchers highlight the need to develop a more fine-grained theory of motivation and innovation. In addressing these literature gaps, this paper takes college teachers as the sample and focuses on the motivational mediating mechanism between online IL and innovation. The results showed that teachers IL could positively predict innovative teaching performance. Personal teaching efficacy and autonomous motivation played as sequential mediators on the link between IL and innovative teaching performance. This study extends the literature of IL–innovation relationship and enriches understanding of cognition-oriented motivation theory, highlighting one's internal autonomous construction is the key to innovation. Theoretical and practical implications for psychological empowerment are discussed.
The Social Roots of Suicide: Theorizing How the External Social World Matters to Suicide and Suicide Prevention
Authors: Mueller Anna S. , Abrutyn Seth , Pescosolido Bernice , Diefendorf Sarah
Published: March 2021

The past 20 years have seen dramatic rises in suicide rates in the United States and other countries around the world. These trends have been identified as a public health crisis in urgent need of new solutions and have spurred significant research efforts to improve our understanding of suicide and strategies to prevent it. Unfortunately, despite making significant contributions to the founding of suicidology – through Emile Durkheim’s classic Suicide (1897/1951) – sociology’s role has been less prominent in contemporary efforts to address these tragic trends, though as we will show, sociological theories offer great promise for advancing our understanding of suicide and improving the efficacy of suicide prevention. Here, we review sociological theory and empirical research on suicide. We begin where all sociologists must: with Durkheim. However, we offer a more comprehensive understanding of Durkheim’s insights into suicide than the prior reviews provided by those in other disciplines. In so doing, we reveal the nuance and richness of Durkheim’s insights that have been largely lost in modern suicidology, despite being foundational to all sociological theories of suicide – even those that have moved beyond his model. We proceed to discuss broadly acknowledged limitations to Durkheim’s theory of suicide and review how more recent theoretical efforts have not only addressed those concerns, but have done so by bringing a larger swatch of sociology’s theoretical and empirical toolkit to bare on suicide. Specifically, we review how recent sociological theories of suicide have incorporated insights from social network theories, cultural sociology, sociology of emotions, and sociological social psychology to better theorize how the external social world matters to individual psychological pain and suffering. We conclude by making explicit bridges between sociological and psychological theories of suicide; by noting important limitations in knowledge about suicide – particularly regarding the roles of organizations, inequality, and intersectionality in suicide – that sociology is well situated to help address.
Psychological Differences Among Healthcare Workers of a Rehabilitation Institute During the COVID-19 Pandemic: A Two-Step Study
Authors: Panzeri Anna , Rossi Ferrario Silvia , Cerutti Paola
Published: March 2021

Introduction:Healthcare workers facing the threatening COVID-19 can experience severe difficulties. Despite the need to evaluate both the psychological distress and positive protective resources, brief and reliable assessment tools are lacking.

Aim:Study 1 aimed at developing a new assessment tool to measure psychological distress and esteem in healthcare workers during the COVID-19 pandemic. Study 2 aimed to explore and compare the psychological reactions of healthcare workers of the COVID-19 and the non-COVID-19 wards.

Methods:In Study 1, psychologists created 25 items based on their clinical experience. A preliminary qualitative evaluation selected the best 15 items for the new tool (CPI-HP) assessing the COVID-19 psychological impact with 2 scales: psychological distress and esteem. The CPI-HP was administered to 110 healthcare professionals to study its psychometric properties and the internal structure with exploratory graph analysis and confirmatory factor analysis. Study 2 compared two groups of healthcare professionals of the COVID-19 and non-COVID-19 departments.

Results:In Study 1, the CPI-HP showed satisfying psychometric properties, and the two-factor structure was confirmed with good fit indices. In Study 2, the two groups of healthcare workers showed comparable levels of psychological distress and resilient coping, but the COVID-19 group displayed significantly higher esteem and appreciation of the experience.

Discussion:All operators showed high psychological distress during the emergency, but the COVID-19 group reported higher resources, probably due to stronger group cohesion and greater esteem, perceived meaning, and own work value.

Conclusion:Assessing the psychological distress and resources of healthcare professionals with specific tools is important. Psychological interventions should promote their psychological health.
The Effect of Attribute Alignability on Product Purchase: The Moderating Role of Product Familiarity and Self-Construal
Authors: Zhang Yong , Wen Yuwen , Hou Min
Published: March 2021

Previous studies on the Structural Alignment Model suggest that people compare the alignable attributes and nonalignable attributes during the decision-making process and preference formation process. Alignable attributes are easier to process and more effective in clue extracting. Thus, it is believed that people rely more on alignable than nonalignable attributes when comparing alternatives. This article supposes that consumers’ product experience and personal characteristics also play a significant role in regulating consumers’ reliance on attribute alignability. The authors conducted three experiments to examine the moderating role of consumers’ product familiarity and self-construal in the impact of attribute alignability on consumer product purchase. The results show the following: (1) When making a purchase decision, consumers with a high level of product familiarity will rely more on nonalignable attributes, while those with a low level of product familiarity will rely more on alignable attributes. (2) The difference in consumer dependency on attribute alignability is driven by their perceived diagnosticity of attributes. (3) The dependency of consumers with different levels of familiarity on attribute alignability will be further influenced by consumers’ self-construal. Individuals with interdependent self-construal rely more on alignable attributes when unfamiliar with the product, while relying more on nonalignable attributes when familiar with the product. Individuals with independent self-construal, however, rely more on nonalignable attributes regardless of the degree of product familiarity. The conclusions of this paper can be used as references for enterprises to establish product positioning and communication strategies.
Beyond the Senses: How Self-Directed Speech and Word Meaning Structure Impact Executive Functioning and Theory of Mind in Individuals With Hearing and Language Problems
Authors: Camminga Thomas F. , Hermans Daan , Segers Eliane , Vissers Constance T. W. M.
Published: March 2021

Many individuals with developmental language disorder (DLD) and individuals who are deaf or hard of hearing (D/HH) have social–emotional problems, such as social difficulties, and show signs of aggression, depression, and anxiety. These problems can be partly associated with their executive functions (EFs) and theory of mind (ToM). The difficulties of both groups in EF and ToM may in turn be related to self-directed speech (i.e., overt or covert speech that is directed at the self). Self-directed speech is thought to allow for the construction of non-sensory representations (i.e., representations that do not coincide with direct observation). Such non-sensory representations allow individuals to overcome the limits set upon them by the senses. This ability is constrained by the development of word meaning structure (i.e., the way words are understood). We argue that the greater ability to construct non-sensory representations may result in more enhanced forms of EF and ToM. We conclude that difficulties in EF, ToM, and social–emotional functioning in those with hearing and language problems may be accounted for in terms of word meaning impairments. We propose that word meaning structure and self-directed speech should be considered in assigning EF and ToM treatments to individuals with DLD and those who are D/HH.
COVID-19: Are School Counseling Services Ready? Students' Psychological Symptoms, School Counselors' Views, and Solutions
Authors: Karaman Mehmet Akif , Eşici Hasan , Tomar İsmail Hakkı , Aliyev Ramin
Published: March 2021

The purpose of the current study was to investigate the effects of COVID-19 on high school students' psychological symptoms and to understand how ready counselors and school counseling services are based on the data we have. Therefore, this research is designed under two different studies: (A) Study 1: Effects of COVID-19 pandemic on students' psychological symptoms and (B) Study 2: Views and expectations of students and school counselors about school counseling services. The first study was a quantitative study and included 549 high school students (398 female, 151 male). A structural equation model (SEM) was created to examine the effects of COVID-19 pandemic on participants' psychological symptoms. The Impact of Event Scale-Revised (IES-R) scores showed that 107 (19.50%) individuals had a score of 50 and above pointing out that individuals in this group had severe impact of event/trauma symptomologies. The SEM analysis indicated that IES-R scores had a total effect of 0.79 on anxiety, 0.75 on depression, 0.74 on negative self-concept, 0.68 on somatization, and 0.66 on hostility scores. Furthermore, female students had significantly higher scores on anxiety, depression, negative self-concept, somatization, hostility, and impact of events variables than male students. Study 2 was a qualitative design and consisted of five school counselors and five students from different schools. The results indicated that students' difficulties during the coronavirus disease 2019 (COVID-19) outbreak were educational, cognitive, emotional, physiological, relational, technological, and related to routines. Academic, social, emotional, and behavioral issues came to the fore among the difficulties that can be experienced if students start face-to-face education. On the other hand, the school counselors listed that family relations, personal–social, emotional, and academic themes were the difficulties experienced by the students at the beginning of the COVID-19. In addition, when COVID-19 started, the services offered by school counselors were discussed under (1) services for the student, (2) services for the family, and (3) services for the teacher. Finally, according to the opinions of the school counselors, if students start face-to-face education, they may experience emotional, academic, and relational difficulties. In summary, it is vital that student personality services be prepared and implemented by school counseling services for schools based on the results.
miRNA and mRNA Profiles in Ventral Tegmental Area From Juvenile Mice With Companion Communication of Improving CUMS-Induced Depression-Like Behaviors
Authors: Song Zhenhua , Wang Jin-hui
Published: March 2021

Under chronic stress, the appearance of depression-like behaviors may be related to the decline of the brain's reward circuit function which caused by long-term lack of reward. However, the effect of reward treatment on depressive-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, accompanying with companion was used to imitate a reward to study the effect of reward on depression-like behaviors induced by chronic unpredicted mild stress (CUMS), and high-throughput sequencing was used to analyze the miRNA and mRNA profiles in ventral tegmental area (VTA) harvested from depression-like and resilient behaviors mice. We observed that CUMS-induced depression-like behaviors were ameliorated by accompanying with companion in mice, and 202 differentially expressed genes (DEGs) were found to be associated with depression-like behaviors, 27 DEGs associated with resilience, 159 DEGs associated with accompanying with companion. Importantly, we also obtained 228 differentially expressed miRNAs that associated with accompanying with companion. Furthermore, the miRNA-mRNA network associated with companion was established in ventral tegmental area, based on the miRNA and mRNA profiles. Altogether, our results uncover a new way to ameliorate depression-like behavior, as well as many potential drug targets to prevent or treat depression.
To Be or Not to Be a Chechen? The Second Generation of Chechens in Europe and Their Choices of Identity
Authors: Iliyasov Marat
Published: March 2021

Approximately a quarter of Chechnya's population left the republic due to the Russo-Chechen wars and the brutality of the regime established after them. Many of the Chechen migrants settled in Europe where cultural, religious, and social differences compelled them to go through the daunting process of identity negotiation. Although most of the first-generation Chechen migrants managed to preserve their original identity, this was not always the case for their children. This article aims to identify the factors that determine the identity preferences of second-generation Chechens in Europe. The paper presents three cases which illustrate very different outcomes of the identity formation and negotiation processes. This ethnographic study concludes that home education impacted the identity choices of the migrants' children the most.
Handedness and Relative Age in International Elite Interactive Individual Sports Revisited
Authors: Loffing Florian , Schorer Jörg
Published: March 2021

Relative age effects (RAE) describe the unintended side effect of annual age grouping such that athletes born close to a specific cutoff date are more likely to be associated with attaining higher performance status than athletes born later. One factor suggested to override the RAE is handedness. Given the left-handers' rarity and their proposed performance advantage in interactive sports, left-handedness may be associated with a lower likelihood of suffering from selection inequalities like RAE in those sports compared with right-handedness. Here, in a two-study approach, we tested that hypothesis by examining male and female athletes from various interactive individual sports sampled over a 10-year period from 2007 to 2016. Study 1 investigated distributions of birth and handedness of senior athletes listed in the top 200 of year-end world rankings in table tennis, tennis, squash, and fencing (épée, foil, and saber). Study 2 followed a similar design but focused on junior athletes in the fencing disciplines and tennis. Unlike the above prediction, in both studies, birth distribution was not found to be reliably associated with handedness in any of the sports or disciplines considered. Left-handers were consistently overrepresented in épée, foil, and table tennis, occasionally in saber and tennis, and not at all in squash. Birth frequencies decreased from quartile Q1 (January to March) to Q4 in almost any sporting domain at the junior level, whereas such trend was rarely found at the senior level. In conclusion, while providing novel insight on the role handedness may play at the junior level, our findings do not support the hypothesis that left-handedness helps override birth-related inequalities in high sporting achievement in elite interactive individual sports.
Relationship between Changes over Time in Factors, Including the Impact of Meteorology on Photochemical Oxidant Concentration and Causative Atmospheric Pollutants in Kawasaki
Authors: Fukunaga Akinori , Sato Takaharu , Fujita Kazuki , Yamada Daisuke , Ishida Shinya , Wakamatsu Shinji
Published: March 2021

To clarify the relationship between changes in photochemical oxidants’ (Ox) concentrations and their precursors in Kawasaki, a series of analyses were conducted using data on Ox, their precursors, nitrogen oxides (NOx) and volatile organic compounds (VOCs), and meteorology that had been monitored throughout the city of Kawasaki for 30 years from 1990 to 2019. The trend in air temperature was upward, wind speed was downward, and solar radiation was upward, indicating an increasing trend in meteorological factors in which Ox concentrations tend to be higher. Between 1990 and 2013, the annual average Ox increased throughout Kawasaki and remained flat after that. The three-year moving average of the daily peak increased until 2015, and after that, it exhibited a slight decline. The amount of generated Ox is another important indicator. To evaluate this, a new indicator, the daytime production of photochemical oxidant (DPOx), was proposed. DPOx is defined by daytime averaged Ox concentrations less the previous day’s nighttime averaged Ox concentrations. The trend in DPOx from April to October has been decreasing since around 2006, and it was found that this indicator reflects the impact of reducing emissions of NOx and VOCs in Kawasaki.
Correction: Camiola, V.D., et al. Equilibrium Wigner Function for Fermions and Bosons in the Case of a General Energy Dispersion Relation. Entropy 2020, 22, 1023
Authors: Camiola Vito Dario , Luca Liliana , Romano Vittorio
Published: March 2021

In Section 5 of Equilibrium Wigner Function for Fermions and Bosons in the Case of a General Energy Dispersion Relation [...]
Methodology for Developing a Macro Finite Element Model of Lithium-Ion Pouch Cells for Predicting Mechanical Behaviour under Multiple Loading Conditions
Authors: Beaumont Richard , Masters Iain , Das Abhishek , Lucas Steve , Thanikachalam Arunn , Williams David
Published: March 2021

To assist in light weighting of electric vehicles by improving the volumetric and gravimetric energy density and the structural performance of the battery pack, a modelling methodology based on a macro finite element model of a pouch cell has been developed. This model treats the core cell structure as a homogeneous orthotropic honeycomb block with the pouch material being defined as an orthotropic fabric with compressive stress elimination. The model considers five compression and bending load cases simultaneously and allows a level of element discretisation that is computationally efficient and appropriate for inclusion in full vehicle and sub-system simulations. The methodology is scalable in that it can be applied to a range of chemistries, external geometries and internal cell constructions. When considering stacks of cells, the model is predictive for both lateral compression and three-point bend, but further work is required to improve the confined compression response.
Electric Distribution System Planning Methodology Considering Distributed Energy Resources: A Contribution towards Real Smart Grid Deployment
Authors: Picard José Luis , Aguado Irene , Cobos Noemi G. , Fuster-Roig Vicente , Quijano-López Alfredo
Published: March 2021

Within the current context of energy transition, the first step to assure cost-efficient and reliable grid operations is the use of adequate planning tools. These tools must evaluate the real needs for reinforcing, replacing and incorporating new network assets considering not only technical and regulatory aspects but also the operational benefits that distributed energy resources (DER) may provide. With this purpose, this paper presents a novel methodology for the analysis and the advanced planning of the active distribution networks in the context of smart grids. The main contributions of the proposed methodology are the following: to incorporate the real capabilities of DER proactively to the planning and operation of distribution networks; to appropriately use the data available in current smart grids; and to promote the efficient use of network capacity in distribution level (efficiency decisions of its users, grid assets in service, access conditions, etc.) through potential operational services, variable in time. The proposed methodology was successfully tested on a real distribution network with 450,000 delivery points on a geographical area of 5000 km2.
Analysis and Evaluation of Heat Pipe Efficiency to Reduce Low Emission with the Use of Working Agents R134A, R404A and R407C, R410A
Authors: Adrian Łukasz , Szufa Szymon , Piersa Piotr , Kuryło Piotr , Mikołajczyk Filip , Kurowski Krystian , Pochwała Sławomir , Obraniak Andrzej , Stelmach Jacek , Wielgosiński Grzegorz , Czerwińska Justyna , Kubiak Przemysław
Published: March 2021

This paper presents an analysis of methods to increase the efficiency of heat transfer in heat exchangers. The scope of the research included analysis of efficiency optimization using the example of two tubular heat exchanger structures most often used in industry. The obtained efficiency of heat recovery from the ground of the examined exchangers was over 90%, enabling the reduction of emissions of the heating systems of buildings. The paper presents the results of tests of two types of heat pipes using R134A, R404A, and R407C working agents. The paper also presents the results of experimental tests using the R410A working medium. The results included in the study will also enable the effective use of land as a heat store.
The Possibilities to Reduce Arc Flash Exposure with Arc Fault Eliminators
Authors: Nowak Karol , Janiszewski Jerzy , Dombek Grzegorz
Published: March 2021

This paper presents a method to limit the arc energy and hence the hazard risk category value according to IEEE 1584 by using a system of two oppositely connected multi-sectional thyristor branches. A test circuit for testing the effectiveness of a thyristor arc eliminator was designed and constructed. Arc ignition inside electrical switchgear can be a source of danger for technical personnel. The arc energy calculated according to the algorithms in IEEE 1584 can be significantly reduced by using multi-sectional arc eliminator MSAE. For the actual measuring object, the calculation of the hazardous arc flash zone and the hazard category was carried out for the system not equipped with an arc eliminator, and then the same was performed in a system with an arc eliminator. In parallel, the pressure inside the closed polyvinyl chloride (PVC) electrical box enclosure was measured and then compared with the calculated pressures that could occur during an arc fault. It was found that a Multi-Sectional Arc Eliminator (MSAE) effectively protects devices supplied from low voltage networks against the effects of short circuit or arc fault, such as the sudden increase of gas pressure inside the switchboard, which may cause it to break, significantly reduce the loss of electrode material, limit the spread of hot electrode material outside the switchgear, and also significantly reduces the energy of the electric arc.
Planning and Settlement Conditions for the Development of Renewable Energy Sources in Poland: Conclusions for Local and Regional Policy
Authors: Śleszyński Przemysław , Nowak Maciej , Brelik Agnieszka , Mickiewicz Bartosz , Oleszczyk Natalia
Published: March 2021

The article presents an analysis of geographical-settlement and legal-planning conditions for the development of Poland’s distributed generation. The choice of this country is important and interesting due to the highly dispersed settlement, which may be a factor stimulating the development of this type of energy systems. For this reason, the analysis can be a model for other countries and regions, indicating ways to analyze and evaluate settlement and planning conditions for the development of renewable and distributed energy. At the same time, Poland is struggling with a severe crisis of spatial planning. By analysing these opportunities and threats, empirical analyses try to indicate regularities in this respect in Poland’s regions in a detailed approach to communes and detailed legal and planning conditions. The conclusions emphasise the usefulness of distributed generation development for peripheral and sparsely populated areas of Europe and other parts of the world and appropriate directions of changes in spatial development law.
Standardization Challenges, Opportunities and Recent Evolutions for the G3-PLC Technology
Authors: Lavenu Cédric , Chauvenet Cédric , Treffiletti Paolo , Varesio Matteo , Hueske Klaus
Published: March 2021

Considering the intrinsic benefits of power line communications, the long-lasting lifetime of industrial systems and the growth of IoT, PLC technologies will be part of the worldwide industrial landscape for many decades. This paper discusses the history of the G3-PLC technology and current challenges and opportunities identified in real systems. Finally, it introduces recent evolutions within the G3-PLC standard, which bring additional performance and versatility, enhancing the relevance of G3-PLC as a complementary technology to other telecommunication systems in a 5G-driven telecommunication technology landscape.
Adopting a Conversion Design Approach to Maximize the Energy Density of Battery Packs in Electric Vehicles
Authors: Pierri Erika , Cirillo Valentina , Vietor Thomas , Sorrentino Marco
Published: March 2021

Innovative vehicle concepts have been developed in the past years in the automotive sector, including alternative drive systems such as hybrid and battery electric vehicles, so as to meet the environmental targets and cope with the increasingly stringent emissions regulations. The preferred hybridizing technology is lithium-ion battery, thanks to its high energy density. The optimal integration of battery packs in the vehicle is a challenging task when designing e-mobility concepts. Therefore, this work proposes a conceptual design procedure aimed at optimizing the sizing of hybrid and battery electric vehicles. Particularly, the influence of the cell type, physical disposition and arrangement of the electrical devices is accounted for within a conversion design framework. The optimization is focused on the trade-off between the battery pack capacity and weight. After introducing the main features of electric traction systems and their challenges compared to conventional ones, the relevant design properties of electric vehicles are analyzed. A detailed strategy, encompassing the selection of battery format and technology, battery pack design and final assessment of the proposed set-up, is presented and implemented in an exemplary application, assuming an existing commercial vehicle as the reference starting layout. Prismatic, cylindrical and pouch cells are configured aiming at achieving installed battery energy as close as possible to the reference one, while meeting the original installation space constraint. The best resulting configuration, which also guarantees similar peak power performance of the reference battery-pack, allows reducing the mass of the storage system down to 70% of its starting value.
Learning to Live with the Killing Fields: Ethics, Politics, Relationality
Authors: Dam Lincoln
Published: March 2021

The Killing Fields call into question my very being. How are we to live in and with the aftermath of an estimated 1.7 million people perishing? How are we, the survivors of this calamity, to discern our family (hi)stories and ourselves in the face of these irreparable genealogical fractures? This paper begins with stories—co-constructed with my father—about the Killing Fields, a genocide orchestrated by the Khmer Rouge and from which humanity appears to suffer a collective amnesia. The latter half of this paper turns to my engagements with ethical-political philosophy as a means to comprehend and make meaning of the atrocities described by my father. Drawing principally on the Yin-Yang philosophy and Thai considerations of the face, I respond to keystone Khmer Rouge ideas and strategies that “justified” the murder of over one million people. Philosophy teaches me to learn from and how to live with the Killing Fields. It offers me routes to make sense of my roots in the absence of treasure troves that would typically inform the writing of genealogies and family (hi)stories. This paper gives testimony to a tragedy of the past that is inscribed in the present and in the yearning for a better tomorrow.
Overview of Self-Management Skills and Associated Assessment Tools for Children with Inflammatory Bowel Disease
Authors: Vernon-Roberts Angharad , Gearry Richard B. , Day Andrew S.
Published: March 2021

Self-management is a multi-modal approach for managing chronic conditions that encompasses a number of different elements; knowledge, adherence, self-regulation, communication, and cognitive factors. Self-management has been shown to be beneficial for adults with inflammatory bowel disease (IBD), and for children with IBD it may help them learn to take control of their complex treatment regimens and lead to positive disease outcomes. The development of self-management skills for children with IBD is vital in order to maximize their potential for health autonomy, but it is still an emergent field in this population. This review provides an over-arching view of the self-management elements specific to children with IBD, and highlights outcome measures that may be used to assess skills within each field as well as the efficacy of targeted interventions.
A Global-Scale Investigation of Stochastic Similarities in Marginal Distribution and Dependence Structure of Key Hydrological-Cycle Processes
Authors: Dimitriadis Panayiotis , Koutsoyiannis Demetris , Iliopoulou Theano , Papanicolaou Panos
Published: March 2021

To seek stochastic analogies in key processes related to the hydrological cycle, an extended collection of several billions of data values from hundred thousands of worldwide stations is used in this work. The examined processes are the near-surface hourly temperature, dew point, relative humidity, sea level pressure, and atmospheric wind speed, as well as the hourly/daily streamflow and precipitation. Through the use of robust stochastic metrics such as the K-moments and a second-order climacogram (i.e., variance of the averaged process vs. scale), it is found that several stochastic similarities exist in both the marginal structure, in terms of the first four moments, and in the second-order dependence structure. Stochastic similarities are also detected among the examined processes, forming a specific hierarchy among their marginal and dependence structures, similar to the one in the hydrological cycle. Finally, similarities are also traced to the isotropic and nearly Gaussian turbulence, as analyzed through extensive lab recordings of grid turbulence and of turbulent buoyant jet along the axis, which resembles the turbulent shear and buoyant regime that dominates and drives the hydrological-cycle processes in the boundary layer. The results are found to be consistent with other studies in literature such as solar radiation, ocean waves, and evaporation, and they can be also justified by the principle of maximum entropy. Therefore, they allow for the development of a universal stochastic view of the hydrological-cycle under the Hurst–Kolmogorov dynamics, with marginal structures extending from nearly Gaussian to Pareto-type tail behavior, and with dependence structures exhibiting roughness (fractal) behavior at small scales, long-term persistence at large scales, and a transient behavior at intermediate scales.