bluuebunny/crossref_metadata_2025 huggingface dataset:
ВИВЧЕННЯ ВЛАСТИВОСТЕЙ НОВИХ ДЕЗІНФЕКЦІЙНИХ ПРЕПАРАТІВ ЩОДО ЕНТЕРОБАКТЕРІЙ ТА ГРИБІВ
Authors: Наливайко Людмила Іванівна , Бойко Віктор Сергійович
Published: November 2023

Пошук нових високоефективних засобів для дезінфекції з метою профілактики інфекційних захворювань залишається актуальним і по сей день. У короткий термін препарати повинні ліквідувати збудників хвороб, що потребує особливого підходу до вибору методів та засобів дезінфекції. Для практичної ветеринарної медицини особливий інтерес становлять препарати, що забезпечують комплексну віруліцидну, бактерицидну та фунгіцидну дії. Задачею дезінфекції є попередження або ліквідація процесів накопичення, розмноження і поширення збудників захворювань шляхом їх знищення або видалення на предметах і об'єктах, що забезпечує переривання шляхів передачі заразного початку. У зв'язку з цим виникла потреба у розробці та випробуванні нових дезінфікуючих засобів. Наші дослідження були направлені на вивчення властивостей і застосування бактерицидних препаратів на основі наночастинок срібла Ag та комбінацію з вісмутом (Ag+Ві), а також бактеріологічної і фунгіцидної оцінки удосконаленого дезінфекційного препарату «Сандезвет» (СДВ) на основі четвертинно-амонієвих сполук (ЧАС) та амінів, які теоретично обґрунтовують і практично підтверджують ефективність його використання у птахівництві. Встановлено, що бактерицидна дія матричного розчину наночастинок Ag і Ag+Bi відбулась тільки через 24 години за температури 37,5 (+0,5) о С. При вивченні бактерицидної дії деззасобу “Сандезвет” на тест-культури (Escherichia coli, Salmonella Dublin, Staphylococcus aureus), а також Proteus vulgaris та Pseudomona auroginosa встановлено, що дезінфікуючий засіб діє бактерицидно по відношенню до ентеробактерій у концентраціях 0,5% з експозицією 1 година за температури 37,5 о С. До польових ізолятів протея і стафілококу – бактерицидність препарату встановлена у 5% концентрації. При застосуванні комбінації СДВ+ПАР (0,02%) бактерицидну дію препарату на тест-об’єктах на патогенні види мікроорганізмів проявляє 1 % розчин СДВ+ПАР з експозицією 0,5 годин. Деззасіб «Сандезвет» можна використовувати як фунгістатичний засіб проти плісеневих грибів родів Aspergillus Mich. та Penicillium Link у 3,0 % концентрації та як фунгіцидний у 5,0 % концентрації впродовж 60 хв. Встановлено, що 5 % концентрація препарату СДВ+ПАР вбиває гриби, які вражають солому, лушпиння та стружку з дерева протягом 24 годин. На підставі отриманих результатів засіб «Сандезвет» може бути застосований при дезінфекції різних виробничих об’єктів та інфекційних захворювань бактеріальної і грибкової етіології.
ВИЗНАЧЕННЯ ВПЛИВУ ПРЕПАРАТУ «ІНКОМБІВІТ» ТА «АСПІР-35» НА ПРОДУКТИВНІСТЬ, ЯКІСТЬ ЯЄЦЬ, ГЕМАТОЛОГІЧНІ ПОКАЗНИКИ СИРОВАТКИ КУРЕЙ-НЕСУЧОК, ПРИ ЗАСТОСУВАННІ ПРОТЯГОМ ЛІТНЬОГО СЕЗОНУ
Authors: Калюжна Тетяна Миколаївна , Фотін Олексій Володимирович
Published: November 2023

Це дослідження мало на меті визначити ефективність доповнення раціонів курей вітамінами шо містяться у складі препарату «Інкомбівіт», а саме: вітаміну А– 15 000 МО, вітаміну D3 – 7 500 МО, вітаміну Е – 20 мг, вітаміну B1 – 10 мг, вітаміну B2 – 5 мг, вітаміну B3 (нікотинамід) – 50 мг, вітаміну B4 (холіну хлорид) – 12,5 мг, вітаміну B5 (Д-пантенол) – 25 мг, вітаміну B6 – 3 мг, вітаміну B7 (біотин) – 0,125 мг, вітаміну B9 (фолієва кислота) – 0,15 мг, вітаміну B12 – 0,05 мг, в поєднанні з «Аспір-35»- препаратом що містить: кислоту ацетилсаліцилову – 350 мг, кислоту бурштинову – 90 мг та кислоту лимонну – 160 мг. на продуктивність, якість яєць, гематологічні показники сироватки курей-несучок, при їх застосуванні протягом літнього сезону, а саме з метою профілактики теплового стресу. «Інкомбівіт» є комбінованим препаратом, який окрім жиро – та водорозчинних вітамінів містить мікроелементи та амінокислоти, які мають здатність нормалізувати обмін речовин, впливають на підвищення загальної резистентності. Всі три органічні кислоти які містить препарат «Аспір-35» (саліцилова, бурштинова і лимонна) приймають участь в регуляції окисно-відновних процесів, білкового, вуглеводного та мінерального обміну, стимулюють роботу печінки, впливають на зсідання крові, проникливість капілярів та формування стероїдних гормонів. Являючись антиоксидантами і антигіпоксантамии, вони піддаються трансформації в циклі Кребса та забезпечують клітини вуглекислим газом і енергією за рахунок накоплення АТФ і НАДФ. Органічні кислоти що містяться в Аспір-35 спрямовують теплову енергію організму на синтез глікогену, АТФ і НАДФ, що знижає перегрів птиці. Паралельне охолодження організму відбувається за рахунок розширення капілярів шкіри, яке забезпечує ацетилсаліцилова кислота. Загалом 150 курей-несучок породи Легорн було використано для дослідження. Птахи були розподілені на контрольну та дослідні групи з ідентичними умовами годівлі. Перша група була контрольною (група І), контрольній групі давали тільки базовий раціон. Група (ІІ) – дослідна група, якій випоювали «Інкомбівіт». Група (ІІІ) – дослідна група якій випоювали «Інкомбівіт» в поєднанні з «Аспір-35». Дослідні препарати випоювали через систему водопостачання після заповнення пташника в літній період. Проводили лабораторні дослідження проб сироватки крові. В результаті отриманих даних можна зробити висновок, що застосування в поєднанні обох дослідних препаратів в літній- спекотний період «Інкомбівіту» та «Аспір-35» мало хороший результат в зменшенні шкідливого впливу високої температури навколишнього середовища на курей-несучок.
ОСОБЛИВОСТІ ВИРОБНИЦТВА ТОМАТНОЇ ПАСТИ В УМОВАХ ПРОДОВОЛЬЧОЇ БЕЗПЕКИ
Authors: Горач О. О. , Вихованець Р. М.
Published: November 2023

В статті проведено дослідження показників якості томатної пасти, проведено аналіз нормативно-технічної документації та вимог до виробництва, транспортування та зберігання. Особливу увагу приділено існуючим технологіям виробництва та умовам зберігання томатної пасти. Зазначено, що на сьогоднішній день основними виробниками є підприємства різної форми власності Півдня України. Вивчення показників якості та термінів зберігання томатної пасти є актуальним завданням, особливо в контексті забезпечення якості та безпеки харчових продуктів для споживачів. Виробництво томатної пасти в Україні є однією з найрозвиненіших галузей харчової промисловості. Крім того, томатна паста широко використовується в харчовій промисловості при виготовленні різних соусів, овочевої і рибної консервації. Тому попит на цей продукт завжди стабільний і ще не в повній мірі забезпечується вітчизняними виробниками. Вітчизняні виробники томатної пасти використовують різні технології переробки томатів, що впливає на якість і термін зберігання продукту. На сьогоднішній день вітчизняний ринок заповнено томат-продуктами як імпортного, так і вітчизняного виробництва, які не завжди відповідають вимогам нормативних документів. Якість томат-продуктів безпосередньо залежить від якості сировини, що надходить на переробку, серед якої переважно є томати механізованого збору. Тому дослідження показників якості томатної пасти та терміну її придатності є актуальним питанням для забезпечення безпеки та якості продукту для споживачів. Наведені дослідження допоможуть виробникам підвищити якість продукту та дозволить сформувати дієві поради виробникам і споживачам.
Thuật toán song song khai thác nhanh các mẫu trọng số hữu ích phổ biến từ cơ sở dữ liệu định lượng động
Authors: Le Nguyen , Nguyen Ham , Nguyen Minh
Published: November 2023

Trong những năm gần đây, bài toán khai thác các mẫu trọng số hữu ích phổ biến (FWUP) đang được quan tâm nghiên cứu. Đây là một là một biến thể của bài toán khai thác mẫu. Một số phương pháp giải quyết khá hiệu quả bài toán này đã được đề xuất. Tuy nhiên, trong thực tế, khi dữ liệu có kích thước lớn và trọng số các mục thường xuyên thay đổi dẫn đến các thuật toán xử lý tốn nhiều thời gian trong quá trình khai thác mẫu. Nếu tận dụng khả năng tính toán song song của các hệ thống tính toán, hoặc của các bộ vi xử lý đa lõi (multi-core) thì có thể cải thiện được thời gian tính toán của các thuật toán. Trong bài báo này chúng tôi giới thiệu một giải pháp song song hoạt động trên bộ xử lý đa lõi, đặt tên là pdFWUNL, để khai thác các mẫu trọng số hữu ích phổ biến từ cơ sở dữ liệu định lượng động có trọng số các mục thay đổi. Kết quả thực nghiệm cho thấy thời gian khai thác mẫu của thuật toán song song pdFWUNL của chúng tôi hiệu quả hơn phương pháp tuần tự tốt nhất hiện có.
The (in) Visible Father in Moroccan Women’s Writings
Authors: Bartiza Salma , Zrizi Hassan
Published: November 2023

Postcolonial Moroccan women's writings significantly contribute to the re-evaluation of the father-figure. Their narratives reflect a constant battle to challenge patriarchal structures and establish a democratic "imagined community" where women are recognized and celebrated. The female voice rises, and the dominant father is reduced to invisibility as these writers assert their presence and subvert traditional gender roles. This study aims to explore how Moroccan women writers depict the father-figure in their polemical and fictional works. It scrutinizes how they have effectively portrayed the father as a formidable force challenging emancipation. The paper also examines the different manifestations of the father-figure and the various relationships these women writers establish with this pivotal element in their narratives. The findings indicate that these writers ultimately reduce the father-figure to invisibility as they appropriate narratives, feminize language, and celebrate their bodies, breaking free from the patriarchal paradigm.
Exploring the Pedagogical Considerations for the Use and Development of Learning Materials in Moroccan EFL Classrooms
Authors: Eddimani Abdelfattah , Brigui Hind
Published: November 2023

Instructional materials play a significant role in language teaching and learning processes as they provide learners with the input needed for them to learn the language effectively. They also support enriching language instruction and stimulate learners’ interests and motivation. The aims of the present study were to explore Moroccan EFL high school teachers’ perceptions of instructional materials, the criteria they follow when developing materials, the types of learning materials they use besides the textbook, and the challenges they encounter in materials development. For this purpose, the study used a mixed methods design that combines both qualitative and quantitative analysis of the data. The sample of the study consisted of 160 public high school teachers who have different teaching experiences. The instruments that were used to collect data included a questionnaire, classroom observation, and document analysis. The results of the study revealed that teachers hold different perceptions about materials. On the one hand, some teachers view materials as anything that can be used to facilitate language learning, while others relate material to grammar worksheets that can be used to support the understanding of certain grammatical items. Further analysis revealed that the materials they develop for their learners focus on grammar with very little attention to communication. In addition, the findings showed that the textbook is the main learning material used in Moroccan EFL classrooms. However, the majority of teachers reported that they are unsatisfied with the EFL materials they use. Moreover, the findings found that teachers are not well trained and do not have the necessary skills that will allow them to develop effective materials. Also, authentic materials are not easily accessible, and they cannot be easily used. The study concluded with some pedagogical recommendations for Moroccan EFL teachers and materials developers.
Analisa Keandalan Operator Mesin Giling CTC Pada Produksi Teh Kebun Wonosari
Authors: Semnasti Endang Pudji W , Semnasti Faisyah R. Hidayati
Published: November 2023

Teh merupakan komoditas perkebunan yang cukup banyak diminati dan dibutuhkan. Semakin hari, semakin banyak penikmat dan permintaan mengenai macam dan bentuk teh. Pada prosesnya, pengolahan teh membutuhkan keahlian dalam memproses dalam setiap mutunya. Tujuan dari penelitian ini adalah mengidentifikasi faktor apa saja yang mempengaruhi human error pada saat proses giling berlangsung, mengetahui jenis pekerjaan yang mendapatkan nilai HEP tertinggi, Memberikan usulan perbaikan untuk mengurangi human error yang terjadi pada proses pengolahan. Penelitian ini dilakukan di Pabrik Kebun Teh Wonosari. Dari hasil pengamatan diperoleh human error probability terbesar di Pabrik Teh Kebun Wonosari pada proses penggilingan dengan probabilitas sebesar 0,7997584. Dan HEP terendah yaitu pada task menjaga suhu udada max 27oC dengan nilai 0,00000681. Hal yang diusulkan kepada perusahaan untuk mengurangi human error yang terjadi yaitu memberikan pemahaman SOP dan menegaskan mengenai SOP yang berlaku pada proses pengolahan. Perusahaan juga dapat menggunakan nilai HEP sebagai acuan untuk mengurangi human error yang dapat merugikan perusahaan.
Analisis Pengendalian Kualitas Produk Pada PT. XYZ Menggunakan Metode Six Sigma DMAIC
Authors: Semnasti Salsabila Rana Fadhilah , Semnasti Roni Zakaria
Published: November 2023

Kualitas produk memainkan peran sentral dalam mempengaruhi keputusan pembelian konsumen. Salah satu metode yang telah terbukti efektif dalam pengendalian kualitas di industri manufaktur adalah Six Sigma. Pendekatan ini bertujuan meningkatkan kualitas produk dan efisiensi proses produksi melalui metodologi DMAIC (Define, Measure, Analyze, Improve, Control) yang menjadi landasan Six Sigma. Analisis data rework produk brand A PT. XYZ selama Januari 2022 - Juni 2022 telah dilakukan untuk mengidentifikasi akar penyebab cacat dan memahami tingkat kinerja proses produksi. Hasil analisis memfokuskan perbaikan pada tiga jenis cacat utama, yakni jahitan lepas (29%), jahitan tidak rata (24%), dan jahitan loncat (22%). Langkah berikutnya mencakup identifikasi faktor penyebab melalui fishbone diagram serta merumuskan langkah-langkah pengendalian kualitas, seperti pelatihan untuk meningkatkan kapabilitas pekerja, penjadwalan perawatan mesin yang teratur, pengawasan kerja yang ketat, dan sinergi antar departemen. Implementasi Six Sigma DMAIC diharapkan dapat memberikan manfaat besar dengan mengurangi tingkat cacat, meningkatkan efisiensi, dan memastikan konsistensi kualitas produk, sehingga mendukung pencapaian tujuan perusahaan dalam memenuhi kebutuhan dan ekspektasi konsumen.
Perancangan Ulang Tata Letak Fasilitas Bengkel Menggunakan Algoritma Blocplan (Studi Kasus: Bengkel Autobody Repair X)
Authors: Semnasti Bekti , Semnasti Isna Nugraha , Semnasti Daniel Octavian Cahya Putra , Semnasti Sekar Ayu Kartikaning Bonde
Published: November 2023

Kelancaran proses kerja merupakan hal penting dalam suatu lingkungan pekerjaan. Proses kerja yang efektif dan efisien akan meningkatkan hasil produksi. Bengkel Autobody Repair X yang berlokasi Kabupaten Sukoharjo memiliki beberapa keluhan dari pelanggan maupun karyawan. Keluhan pelanggan adalah bau cat yang tercium hingga ke office, sedangkan karyawan mengeluhkan jarak antara tempat penyimpanan cat dan ruang pengecatan sangat jauh. Sehingga diperlukan perbaikan ulang pada tata letak fasilitas bengkel. Penelitian ini menggunakan ARC (activity relationship chart) dan algoritma blocplan. Berdasarkan hasil pengolahan data dipilih layout 8 sebagai alternatif terbaik dengan nilai R-score tertinggi yaitu 0,71 dan memiliki distance score terkecil yaitu 3411.
Prediksi Harga Crude Palm Oil Menggunakan Backpropagation Artificial Neural Network
Authors: Arief Muhammad Firmansyah , Semnasti Trisita Novianti , Semnasti Samsul Amar
Published: November 2023

Kelapa sawit merupakan komoditas terbesar dalam menghasilkan devisa terbesar serta memiliki kontribusinya perekonomian relatif besar dan luas. Produksi kelapa sawit Indonesia sangat menjanjikan dalam memperoleh keuntungan. Sejak tahun 2006 bahwa Indonesia telah menjadi penghasil kelapa sawit terbesar di dunia. Indonesia memiliki peranan penting dalam memasok serta memenuhi dari permintaan minyak nabati dalam skala tingkat global. Permintaan kelapa sawit global dalam seiring berjalan waktu terus meningkat. Indonesia mendukung potensi besar dalam meningkatkan dari nilai tambah pada industri pada turunan kelapa sawit yang dilihat pada permintaan pasar serta penawarannya. Tujuan dari penelitian ini yaitu mengetahui model ANN yang terbaik dalam melakukan peramalan dan mengetahui tingkat akurasi pada model ANN. Manfaat dari penelitian ini yaitu membantu pemerintah dan pengusaha dalam menentukan kebijakan mengenai terkait industri sawit dengan adanya prediksi serta acuan data sebelumnya. Luaran penelitian ini yaitu prediksi harga crude palm oil Indonesia pada masa mendatang. Hasil penelitian yaitu model arsitektur terpilih yaitu 2-16-1 dengan tingkat akurasi 42 % dan harga prediksi crude palm oil mengalami kenaikan dan penurunan setiap bulannya.
Penentuan Segmentation, Targeting, dan Positioning pada wisatawan desa wisata Lon Malang Madura menggunakan K-means Clustering
Authors: Rahma Maulida Putri , Semnasti Fitri Agustina , Semnasti Bain Khusnul Khotimah
Published: November 2023

Pandemi COVID-19 telah menyebabkan penurunan perekonomian dan perdagangan negara-negara di dunia, termasuk Indonesia. Sektor pariwisata merupakan sektor yang terdampak cukup signifikan sebagai akibat adanya pembatasan kegiatan masal (lockdown). Kini sektor pariwisata mulai bangkit dan menjadi sektor alternatif dalam pertumbuhan perekonomian di Indonesia. Namun, pengembangan pariwisata khususnya di Madura masih sangat konvensional dan berorientasi jangka pendek. Oleh karena itu, diperlukan suatu usaha untuk memetakan wisatawan menurut variabel-variabel demografi, geografi, psikografi dan perilaku sehingga dapat dirumuskan strategi pengembangan yang tepat dan berorientasi pada wisatawan. Metode yang digunakan adalah K-means clustering dan menghasilkan tiga cluster wisatawan pada desa wisata Lon Malang. Selain segmentasi, maka akan ditentukan target pasar yaitu segmen 2 dan segmen 3 hasil dari prioritas uji K-means clustering yang menjadi target segmen karena memiliki persentase anggota cluster tertinggi dan memetakan posisi destinasi wisata ini dengan kompetitornya sesuai dengan low priority, concentrate hare, keep up the good work, dan possible overkill.
Strategi Pemasaran Pengembangan Usaha Menggunakan Metode Analisis SWOT dan QSPM di Industri TI
Authors: Semnasti Rizky Nur'aini , Dewi Sinta , Apriyanti Yeni
Published: November 2023

PT XYZ ialah perusahaan yang bergerak di bidang Software ERP. Perangkat lunak ERP adalah kumpulan program yang membantu bisnis mengelola dan mengintegrasikan proses operasional mereka yang berbeda. PT XYZ adalah salah satu perusahaan dengan perkembangan yang pesat, namun saat ini terdapat beberapa masalah dalam pendistribusian produk di pasar. Tujuan dari penelitian ini adalah untuk mengidentifikasi variabel internal dan eksternal yang mungkin berdampak pada PT XYZ. Quantitative Strategic Planning Matrix (QSPM) dan analisis SWOT digunakan dalam metodologi deskriptif penelitian ini. Menurut temuan, analisis SWOT dan QSPM yang dilakukan dengan menggunakan IFAS dan EFAS berdasarkan faktor internal dan eksternal, diketahui bahwa dalam analisis IE PT XYZ berada pada sel 1, yaitu Growth and Build, sehingga strategi yang dapat digunakan meliputi strategi intensif (penetrasi pasar, pengembangan pasar, dan pengembangan produk). Penelitian ini berfokus pada industri TI yang belum pernah dilakukan. Implikasi bagi PT XYZ, sangat penting untuk fokus dan mengevaluasi bagaimana strategi pengembangan perusahaan terbaik dapat diimplementasikan.
Strategi Pengembangan Pariwisata Boekit Tinggi Sumenep dengan Metode SWOT dan AHP
Authors: Semnasti Retno Indriartiningtias , Semnasti Ulvi Nabila , Semnasti Shofi Fitrotis Salimah
Published: November 2023

Wisata Boekit Tinggi merupakan salah satu industri pariwisata di daerah Sumenep yang terdampak Covid-19 sehingga jumlah kunjungan wisatawan mengalami penurunan drastis. Jumlah kunjungan pada tahun 2019 sebanyak 33509 kunjungan dan pada tahun 2022 mengalami penurunan menjadi 3996 kunjungan sehingga diperlukan adanya pengembangan oleh pengelola pariwisata. Penelitian ini dilakukan dengan tujuan untuk memberikan rancangan strategi pengembangan pariwisata berdasarkan variabel 4C (Customer, Company, Changes, Competitor). Metode yang digunakan yaitu analisis SWOT (Strenghts, Weaknessess, Opportunities, Threats), sedangkan untuk memilih urutan strategi yang harus diprioritaskan menggunakan metode AHP (Analytic Hierarchy Process). Hasil penelitian menunjukkan terdapat lima stategi terpilih dengan urutan bobot prioritas, dimana tiga strategi dengan bobot tertinggi yaitu melakukan kerja sama dengan pemerintah memperbanyak promosi di billboard, videotron atau poster-poster pusat kota dalam menampilkan seluruh wisata di Sumenep, meningkatkan pelayanan dengan memanfaatkan teknologi yaitu menyediakan pelayanan tiket wisata dengan pembayaran non tunai, membangun cafe ruangan terbuka lengkap dengan makanan dan minuman diatas bukit sehingga pengunjung dapat berkumpul bersama keluarga atau teman sambil menikmati pemandangan dari atas bukit.
Strategi Komunikasi Seacolab.net dalam Membangun Citra Merek (Brand Image) untuk Memperoleh Kepercayaan Publik
Authors: Emeraldien Fikry Zahria , Hayati Kinanti Resmi , Semnasti Saifuddin Zuhri
Published: November 2023

Perkembangan teknologi informasi saat ini mengalami pertumbuhan yang sangat pesat, dan pengaruhnya telah merambah ke berbagai sektor, termasuk dalam dunia bisnis. Salah satu model bisnis yang kini semakin populer adalah bisnis startup yang berbasis internet. Dalam era ini, kita telah menyaksikan banyaknya perusahaan startup yang muncul, sehingga penting bagi mereka untuk melakukan strategi branding guna memperkenalkan diri kepada masyarakat. Branding menjadi kunci utama untuk meningkatkan kesadaran publik terhadap perusahaan. Penelitian ini akan berfokus pada strategi yang diadopsi oleh seacolab.net dalam membangun citra merek (brand image) mereka dengan tujuan mendapatkan kepercayaan masyarakat. Penelitian ini menggunakan metode kualitatif. Data dikumpulkan melalui wawancara mendalam dengan salah satu pendiri seacolab.net serta melalui studi dokumen yang terkait dengan perusahaan ini. Hasil penelitian ini menunjukkan bahwa seaolab.net, sebuah platform pendidikan yang mementingkan kolaborasi dengan institusi pendidikan tinggi, mengadopsi berbagai strategi komunikasi. Mereka mempromosikan diri dengan mengusung konsep internasional yang diperkaya dengan elemen sosial enterprise. Selain itu, mereka lebih fokus dalam memanfaatkan media sosial untuk promosi, menjalin kolaborasi aktif dengan institusi pendidikan tinggi, dan memaksimalkan kemitraan dengan para pemangku kepentingan (stakeholder).
Public Perspective on Hyperlipidemia Drugs and Sentiments About Hyperlipidemia on Twitter
Authors: Hasan Murojil , Wiedyaningsih Chairun , Yasin Nanang Munif
Published: November 2023

Hyperlipidemia is a non-communicable disease (NCD) caused by several factors, such as a person's socioeconomic status, culture, customs, habits, and lifestyle. Through user interaction on social media, we can discover the model anti-hyperlipidemia by extracting information, complaints, suggestions, and calls for help about the treatment, which will play a role as an intervention to reduce hyperlipidemia in Indonesia. This study aimed to identify factors influencing perceptions of hyperlipidemia drugs and resulting sentiment on the social media platform Twitter. This study used user-uploaded tweet data to compare perceptions of hyperlipidemia drugs in 2020 and keywords for hyperlipidemia terms and medicine. Tweets related to anti-hyperlipidemia were extracted by issuing tweets containing advertisements, news, re-tweet, and content outside of health. The tweet data obtained was then carried out through content analysis, including point of view, theme, and sentiment analysis, to identify whether the resulting tweets are positive, neutral, or negative using the Support Vector Machine (SVM) method. We identified 1572 hyperlipidemia-related tweets and 153 specific tweets describing hyperlipidemia medications. Tweets about anti-hyperlipidemia showed 99 tweets from the first-person perspective, 23 from the second-person perspective, 22 from healthcare professionals, and nine unidentifiable (other). Sixty-three tweets talked about the benefits of lipid-lowering drugs, 17 complaint tweets, 49 suggestion tweets, 17 question tweets, and two side effect tweets. Assessing public perceptions and sentiment toward hyperlipidemia treatment can be used to develop strategies to increase treatment adherence, improve treatment outcomes, and target health promotion efforts.
Geometric Design in Architecture: Examination of Tessellation Configurations in Structural Systems
Authors: Takva Çağatay , Gökşen Takva Fulya , Takva Yenal
Published: November 2023

The tessellation method, which is a mathematical concept used in geometric design, is also used in architecture and engineering, as in many other fields. In this study, it is aimed to investigate the tessellation configurations in structural systems within the scope of geometric design in architecture, to show the effectiveness of geometry in the architectural production in these structures and to highlight the tessellation-structure relationship. The number of studies emphasizing tessellation configurations in structural systems is limited. For this reason, the study will contribute to the literature. The research question of the study is how tessellation configurations are applied in structural systems and how this relationship is established. Depending on this research question, eight architectural buildings in different cities with different tessellation configurations were examined within the scope of this study. Content analysis was performed by looking at the architectural features of these structures, and a comparative analysis framework was created with the data obtained. Inferences were made on geometric and architectural features. As a result, it has been seen that tessellation patterns are used and will continue to be used on a wide scale in structural design.
The Critical Length is a Good Measure to Distinguish between Stick Balancing in the ML and AP Directions
Authors: Nagy Dalma J. , Insperger Tamás
Published: November 2023

Seven novice subjects participated in experiments of stick balancing on a linear track in the anterior-posterior (AP) and the medio-lateral (ML) directions. The goal of the experiments was to test how the depth perception in the subjects' AP direction affects balancing performance compared to balancing in the ML direction, where depth perception does not play a role. It is easier to balance longer sticks than shorter ones, therefore balancing performance is measured by the length of the shortest stick that subjects can balance. Subjects were found to be able to balance shorter sticks in the ML direction than in the AP direction: the ratio of the shortest stick lengths in the ML direction relative to the AP direction was in average 0.53. Thus, the additional challenge posed by depth perception in the AP direction is clearly observable. Additionally, repeated trials were carried out for 5 consecutive days to assess the development of balancing skill by using stabilometry analysis. The maximal balance time of the subjects significantly increased with the days of practice.
Occurrence of microplastics (MPs) in Antarctica and its impact on the health of organisms
Authors: Bhardwaj Laxmi Kant
Published: November 2023

Antarctica, and its surrounding environment, is considered untouched, and it is thought that it is free from microplastic (MP) pollution. However, recent studies and science projects have reported MPs in both water and sediment in the South Polar Regions. These reports state that MP pollution occurs in this region due to fishing, tourism, and research activities by the nearby countries, with natural circulation also part of it. The Antarctic Treaty System (ATS) has given attention to MP pollution and has initiated research on it. MPs are tiny plastic particles with a size of less than 5 mm. They have two types: 1. Primary MPs, which have been manufactured directly from various applications like cosmetics and scrubbing, etc. 2. Secondary MPs, which are generated by the photochemical degradation of large plastics. Although several studies have been done, there is a quite gap in our understanding of the concentration, characteristics, and impact of plastics on the ecosystem of the Antarctic Region. The impact of MP pollution in this region may be very high. The presence of MPs is a serious issue that is affecting not only the aquatic environment but also humans. It is an alarming situation that causes environmental damage. The main objective of this paper is to review MP introduction, occurrence in biotic and abiotic components, sources, harmful effects, and detection methods/techniques. This review highlights the various methodologies and analyses like density separation, microscope observation of MP’s properties Fourier-transform infrared spectroscopy (FTIR), and Raman spectrometer, respectively, and urges for more research in the future, giving several recommendations to maintain the pristine region near Antarctica.
Highlights

Antarctica is a pristine land and is separated from other continents
Microplastics (MPs) are ubiquitous in nature with a size of < 5 mm
These tiny particles are of two types primary MPs and secondary MPs
MP pollution occurs in the Antarctic region due to fishing, tourism, and research activities
MPs may be carcinogenic and act as endocrine disruptors in nature
Autologous-allogeneic versus autologous tandem stem cell transplantation and maintenance therapy with thalidomide for multiple myeloma patients over 60 years of age: a prospective phase II study
Authors: Kröger Nicolaus , Wulf Gerald , Hegenbart Ute , Burchert Andreas , Stelljes Matthias , Gagelmann Nico , Brecht Arne , Kaufmann Martin , Müller Lutz , Ganser Arnold , Wolf Dominik , Bethge Wolfgang , Bornhäuser Martin , Kiehl Michael , Wagner Eva-Maria , Schmid Christoph , Reinhardt Christian , Kobbe Guido , Salwender Hans , Heinicke Thomas , Kropff Martin , Heinzelmann Marion , Ayuk Francis , Trümper Lorenz , Neubauer Andreas , Völp Andreas , Kluychnikov Evgeny , Schönland Stefan , Wolschke Christine
Published: November 2023

The role of autologous-allogeneic tandem stem cell transplantation (alloTSCT) followed by maintenance as upfront treatment for multiple myeloma (MM) is controversial.
Between 2008 and 2014 a total of 217 MM patients with a median age of 51 years were included by 20 German centers within an open-label, parallel-group, multi-center clinical trial to compare alloTSCT to auto tandem transplantation TSCT (autoTSCT) followed by a 2-year maintenance therapy with thalidomide (100 mg/d) in both arms with respect to relapse/progression-free survival (PFS) and other relevant outcomes.
A total of 178 patients underwent second SCT (allo n = 132 and auto n = 46). PFS at 4 years after the second SCT was 47% (CI: 38-55%) for alloTSCT and 35% (CI: 21-49%) for autoTSCT (p = 0.26). This difference increased to 22% at 8 years (p = 0.10). The cumulative incidences of non-relapse mortality (NRM) and of relapse at 4 years were 13% (CI: 8-20%) and 2% (CI: 0.3-2%) (p = 0.044) and 40% (CI: 33-50%) and 63% (CI: 50-79%) for alloTSCT and autoTSCT (p = 0.04), respectively. The difference for relapse/progression increased to 33% (alloTSCT: 44%, autoTSCT: 77%) at a median follow-up of 82 months (p = 0.002).
Four-year OS was 66% (CI: 57-73%) for alloTSCT and 66% (CI: 50-78%) for auto TSCT (p = 0.91) and 8-year OS was 52% and 50% (p = 0.87), respectively.
AlloTSCT followed by thalidomide maintenance reduced the rate of recurrence or progression during a follow-up period of up to 10 years but failed to improve PFS significantly.
Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase
Authors: Jeyaraju Danny V. , Alapa Maryam , Polonskaia Ann , Risueño Alberto , Subramanyam Prakash , Anand Amit , Ghosh Kaushik , Kyriakopoulos Charalampos , Hemerich Daiane , Hurren Rose , Wang Xiaoming , Gronda Marcela , Ahsan Aarif , Chiu Hsiling , Thomas Geethu , Lind Evan F. , Menezes Daniel L , Schimmer Aaron D. , Hagner Patrick R. , Gandhi Anita , Thakurta Anjan G.
Published: November 2023

Oral azacitidine (Oral-Aza; CC-486) treatment results in longer median overall survival (OS) (24.7 vs 14.8 months in placebo) in patients with acute myeloid leukemia (AML) in remission after intensive chemotherapy. The dosing schedule of Oral-Aza (14 days/28-day cycle) allows for low exposure of azacitidine for an extended duration thereby facilitating a sustained therapeutic effect. However, the underlying mechanisms supporting the clinical impact of Oral-Aza in maintenance therapy remain to be fully understood. In this preclinical work, we explore the mechanistic basis of Oral-Aza/extended exposure to azacitidine through in vitro and in vivo modeling. In cell lines, extended exposure to azacitidine results in sustained DNMT1 loss, leading to durable hypomethylation, and gene expression changes. In mouse models, extended exposure to azacitidine, preferentially targets immature leukemic cells. In leukemic stem cell (LSC) models, the extended dose of azacitidine induces differentiation and depletes CD34+CD38- LSCs. Mechanistically, LSC differentiation is driven in part by increased myeloperoxidase (MPO) expression. Inhibition of MPO activity either by using an MPO specific inhibitor or blocking oxidative stress, a known mechanism of MPO, partly reverses the differentiation of LSCs. Overall, our pre-clinical work reveals novel mechanistic insights into oral-Aza and its ability to target leukemic stem cells.
Do Products Labeled Retailer “Exclusive” Affect Consumer Behavior?
Authors: Upshaw Danny , Amyx Doug , Upshaw Anna , Hardy Marcia
Published: November 2023

Many large retailers offer “advertised as retailer exclusive products” or AREPs. Retailers work with manufacturers to produce these unique, retailer exclusive versions of otherwise common products. While not all retailer exclusive products are advertised as “exclusive,” AREPs are advertised and labeled as retailer exclusives. The retailer exclusive product attributes are often “trivial,” but still may add customer value and discourage price comparison shopping. Here, two experiments assess AREPs effects on consumers. Contrary to managerial expectations, the findings suggest that AREP exclusivity promotions are ineffective at influencing consumers, but that the choice of exclusive, seemingly “trivial” attribute can sometimes be a significant negative influence on consumers. Further, the authors suggest contexts that may encourage specific responses to retailer exclusive product promotions and trivial attributes.
SOSIALISASI KOPERASI SYARIAH DI RW.04 KELURAHAN PORIS JAYA KECAMATAN BATU CEPER KOTA TANGERANG
Authors: Hawa Siti , Mulatsih Srie Nuning
Published: November 2023

Koperasi syariah merupakan aktivitas usaha pada bidang simpan pinjam,pembiayaan dan investasi yang berdasarkan pada sistem bagi hasil dengan melihat prinsip-prinsip yang ada dalam koperasi, maraknya pinjaman online, investasi ilegal dan pinjaman yang dilakukan oleh rentenir membuat keadaan ekonomi masyarakat Rw.04 Kelurahan Poris Jaya Kota Tangerang telah membuat masyarakat menjadi semakin sulit di bidang ekonomi. Tujuan pengabdian masyarakat ini untuk memberikan pengetahuan yang lebih kepada masyarakat tentang koperasi syariah dan mendorong masyarakat untuk mendirikan koperasi syariah sehingga masyarakat bebas dari pinjaman online,investasi illegal dan renternir. Metode kegiatan sosialisasi ini dilakukan berdasarkan pendekatan ceramah dengan proses pembelajaran teori, kemudian  diskusi dan tanya jawab. Hasil pengabdian masyarakat dapat menambah pengalaman dan  ilmu, pengetahuan dan  pemahaman tentang koperasi syariah dari segala aspek sehingga masyarakat bisa mengetahui lebih dalam dan mampu  mengaplikasikan dalam dunia nyata dengan baik dan benar, dapat menumbuh kembangkan kesadaran warga masyarakat untuk mendirikan koperasi syariah dan dapat mempererat tali silaturahmi antara warga masyarakat bersama  Ketua RW.04 Poris Jaya dengan Universitas Islam Syekh Yusuf.
New comprehensive method for treatment of atrophic skin scars
Authors: Dolgikh S. Yu. , Stenko A. G. , Gryazeva N. V.
Published: November 2023

Striae distensae, commonly known as stretch marks, are visible linear atrophic scars. Despite quite numerous studies, the lack of a unified approachto the problem of treating atrophic scars, a detailed clinical and morphological classification leads to the fact that doctors empirically choosepatient management tactics, which leads to unreliability or even lack of effect, the need for numerous repeated courses of therapy, and significanteconomic costs. The article presents data on studying the effectiveness of various methods of therapy. Depending on the method of therapy,patients were divided into three groups by simple randomization. The study used a visual analogue scale (VAS) to assess the clinical symptomsof AR. The combined use of fractional ablative laser and PDT with the topical photosensitizer chlorin e6 is highly effective in the treatment ofatrophic scars lasting more than a year (VAS dynamics – 74.9 %), fractional ablative laser is moderately effective in long-term atrophic scars (VASdynamics – 65.6 %), while PDT in the form of monotherapy is insufficiently effective (VAS dynamics – 45.6 %).
Merkel cell carcinoma as rare malignant skin tumor (two clinical cases)
Authors: Ravodin R. A. , Kruglova L. S. , Nikitina A. V.
Published: November 2023

This article provides a review of the literature on the prevalence of Merkel carcinoma, the features of its clinical, dermoscopic, pathomorphological diagnosis and therapy. In the light of the presented data, two of our own clinical observations of Merkel carcinoma are described: a clinical and dermoscopic description, a pathomorphological and immunohistochemical picture, the treatment performed and its long-term results are given. In the presented clinical observations, Merkel carcinoma was detected in two women aged 70 and 83 years at stage I, which determined a favorable prognosis. Clinically, the tumor was presented in the form of a dense, non-ulcerated nodule or a pink-red nodule; all neoplasms were localized on the head. The dermoscopic picture was different, in one case it was represented by globules and dots of red color against a background of milky pink and white areas, individual linear and convoluted vessels, there were white structures (like chrysalids), and in another case – structureless areas of pink color with tree-like vessels and white structures in the form of chrysalids. Histologically, the small round cell type of structure predominated. An IHC study in both cases revealed a pronounced expression of cytokeratin 20 and chromogranin A, the Ki‑67 index was above 70 %.
Green nail syndrome caused by Pseudomonas aeruginosa (literature review)
Authors: Tamrazova A. V. , Yakovlev A. B. , Fedina P. I.
Published: November 2023

Green nail syndrome is a bacterial nail disease caused by Pseudomonas aeruginosa, which is characterized by discoloration of the nail plate, onycholysis and proximal paronychia. Despite the prevalence of the pathology and the increase in incidence, today there are no clinical recommendations for the management of patients with chloronychia. This article discusses the etiology, pathogenesis, risk factors, and therapeutic options for managing these patients.
Introduction of telemedicine technologies based on artificial intelligence into practice of providing outpatient care for medical examination
Authors: Seliverstov P. V. , Shapovalov V. V. , Aleshko O. V.
Published: November 2023

To date, the main focus in the implementation of medical activities is focused on the organization of outpatient care for the population. It is at the level of primary health care, where it is possible to carry out primary prevention measures and the formation of a healthy lifestyle, these issues should be given special attention when providing medical care to the population. One of the main tasks of modern healthcare is to reduce the number of chronic non-communicable diseases of the adult population using modern tools of early preclinical diagnostics. To date, one of the most promising areas that have a signiﬁcant impact on modern healthcare is digital telemedicine technologies based on artiﬁcial intelligence. They can be conﬁdently attributed to the most popular and rapidly developing groups of services developed for primary health care for the purpose of primary diagnostics. Nevertheless, no matter how fast information technologies develop, the opinions of experts in the subject area remain relevant, which signiﬁcantly enrich the results of the expert opinion.
Investigating the Role of Pseudocode in Learning Programming Language: A Language Transfer and Typological Similarity Perspective
Authors: Yu Jiaao , Bozic Mirjana
Published: November 2023

This research examined the efficacy of Pseudocode as a tool in teaching a programming language. Fifty-nine participants with no prior programming were divided into three groups: Pseudocode, Java, and Control. The study consisted of three phases: Training, Consolidation, and Testing. During the Training session, participants were presented with segments of code written in either Java or Pseudocode, while the Control group read text passages. After each Training trial participants answered comprehension questions. Consolidation and Testing were identical for all three groups. Consolidation trials consisted of segments of code in Java. Participants were again tested for understanding. In Testing, participants were presented with Java code with three levels of difficulty, evaluating their skills learned from prior sessions. Results showed largely equivalent performance across the three groups in the Training and Consolidation sessions. In the Testing phase, participants from both Pseudocode and Java groups performed better than the Control group on easy and medium questions, confirming that they benefitted from their training. Critically however, while there was no difference between the Pseudocode and the Java groups in easy- or medium- difficulty questions, the Pseudocode group outperformed both the Java and Control groups on difficult questions, implying that Pseudocode can help mitigate the difficulty of learning more complex code. This likely reflects that Pseudocode bridges the typological distance between English and Java, thereby aiding learners in generalizing logic to more complex tasks. However, the exact mechanism requires further investigation. Future studies will also explore how Pseudocode can be optimized to further aid learning.
Examining share repurchase executions: insights and synthesis from the existing literature
Authors: Osterrieder Joerg , Seigne Michael
Published: November 2023

This literature review aims to address the critical knowledge gap in the field of share repurchase executions, a financial activity involving companies repurchasing trillions of dollars' worth of their own shares. The significance of understanding these mechanisms and their impact is underscored by their potential influence on the global economy. The paper employs a comprehensive analysis of existing literature, focusing on share repurchase mechanisms and motivations. It scrutinizes both open-market repurchases and Accelerated Share Repurchase contracts. Methodological approaches in current research, such as the use of partial differential equations and tree methods, are also evaluated. The review reveals that the execution phase of share repurchases remains largely unexplored. Unanswered questions persist about trading schedules, implications, costs, broker and corporate performance, and psychological effects of beating a buyback benchmark. Additionally, the review identifies significant limitations in current research methodologies. The paper advocates for the application and development of more advanced tools like machine learning and artificial intelligence to address these gaps. It also suggests potential areas for future research, including the role of technology in share repurchase execution, psychological factors influencing corporate buybacks, and the development of performance metrics for brokers and corporations. The review serves not only to highlight existing gaps in literature but also to suggest avenues for future research that could fundamentally enhance our understanding of share repurchase executions.

JEL classification

G1, G12, G14, G02, G4.
Patient-specific air puff-induced loading using machine learning
Authors: Desouky Nada A. , Saafan Mahmoud M. , Mansour Mohamed H. , Maklad Osama M.
Published: November 2023

Introduction: The air puff test is a contactless tonometry test used to measure the intraocular pressure and the cornea’s biomechanical properties. Limitations that most challenge the accuracy of the estimation of the corneal material and the intraocular pressure are the strong intercorrelation between the intraocular pressure and the corneal parameters, either the material properties that can change from one person to another because of age or the geometry parameters like central corneal thickness. This influence produces inaccuracies in the corneal deformation parameters while extracting the IOP parametric equation, which can be reduced through the consideration of the patient-specific air puff pressure distribution taking into account the changes in corneal parameters. This air puff pressure loading distribution can be determined precisely from the fluid-structure interaction (FSI) coupling between the air puff and the eye model. However, the computational fluid dynamics simulation of the air puff in the coupling algorithm is a time-consuming model that is impractical to use in clinical practice and large parametric studies.

Methods: By using a supervised machine learning algorithm, we predict the time-dependent air puff pressure distribution for different corneal parameters via a parametric study of the corneal deformations and the gradient boosting algorithm.

Results: The results confirmed that the algorithm gives the time-dependent air puff pressure distribution with an MAE of 0.0258, an RMSE of 0.0673, and an execution time of 93 s, which is then applied to the finite element model of the eye generating the corresponding corneal deformations taking into account the FSI influence. Using corneal deformations, the response parameters can be extracted and used to produce more accurate algorithms of the intraocular pressure and corneal material stress-strain index (SSI).

Discussion: Estimating the distribution of air pressure on the cornea is essential to increase the accuracy of intraocular pressure (IOP) measurements, which serve as valuable indicator of corneal disease. We find that the air puff pressure loading is largely influenced by complex changes in corneal parameters unique to each patient case. With our innovative algorithm, we can preserve the same accuracy developed by the CFD-based FSI model, while reducing the computational time from approximately 101000 s (28 h) to 720 s (12 min), which is about 99.2% reduction in time. This huge improvement in computational cost will lead to significant improvement in the parametric equations for IOP and the Stress-Strain Index (SSI).
Theoretical investigation on a simple turn on fluorescent probe for detection of biothiols based on coumarin unit
Authors: Ma Tianhao , Huang He , Liu Yuling , Peng Yongjin
Published: November 2023

The discovery of a simple and efficient detection method for biothiols would be scientifically significant due to the crucial role of them in various physiological processes. Recently, a simple fluorescent probe, DEMCA-NBSC, based on coumarin fragments, was developed by Ding et al., and provided an efficient way for real-time sensing of biothiols both in vivo and vitro. Theoretical insights to the fluorescence sensing mechanism of the probe were provided in this work. Details of the electron transfer process in the probe under optical excitation and the fluorescent character of the probe were analyzed using a quantum mechanical method. All these theoretical results could inspire the development of a highly convenient and efficient fluorescent probe to sense biothiols both in vivo and vitro.