bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Complexities of the Agricultural Marketing System in India: A Crucial Step Towards an Efficient Marketing System
Authors: Salokhe Shubhangi
Published: September 2024

Background: The process of marketing agricultural produce is a labyrinth of complexities. Indian farmers encounter numerous challenges in their quest for a fair price for their produce. The need for a robust marketing system to reward their efforts is not just pressing but urgent. This study was undertaken to identify the challenges various agriculture marketing models face in the region and propose a new, more efficient model. Methods: The present study is explorative research in nature and primary data is collected from 1086 farmers, 11 APMCs, 25 FPCs, 2 retailers and 10 farmers’ markets in the Pune district. Result: This study unveiled the challenges faced by farmers in adopting non-conventional marketing models. However, these challenges can be overcome with the right encouragement and training. The study’s findings confirmed that combining conventional and non-conventional marketing models can empower farmers in the evolving landscape. They also presented an opportunity to understand the emerging challenges in Indian agriculture and offer a promising path toward doubling farmers’ income in India.
Molecular Characterisation of US6 (gD) and US8 (gE) Glycoprotein Genes Located on a Unique Short Region of Bovine Alphaherpesvirus-1 (BoAHV-1) Genome
Authors: Rashmi L. , Sharada R. , Ratnamma D. , Isloor S. , Chandranaik B.M. , Manjunatha J. , Patil S.S.
Published: September 2024

Background: Bovine alphaherpesvirus type 1 (BoAHV-1) is a significant pathogen causing respiratory diseases and reproductive issues in cattle and buffaloes, resulting in substantial economic losses globally. This study provides a comprehensive analysis of the genetic characteristics of BoAHV-1 isolates from India, focusing on glycoprotein genes US6 (gD) and US8(gE). Methods: Ten archival isolates that were stored at the ICAR-NIVEDI BSL-2 facility were chosen, revived on MDBK cell lines and subjected for molecular characterization through PCR amplification of partial US6 (gD) and US8 (gE) gene. Genome alignment and phylogenetic analysis were performed by GeneTool and Mega 11. Result: Phylogenetic analysis of both genes revealed two cluster formation, BoAHV-1.1, BoAHV-1.2 in one cluster and BoAHV-5, Bubaline alphaherpesvirus (BuAHV-1) in another cluster. All ten isolates displayed close relation to BoAH 1.1. Seven isolates from each phylogenetic analysis showed 100% genome identity to vaccine strains from USA- Bovishield Gold MLV, Pyramid IBR MLV, Switzerland Cooper strain, ATCC Los Angeles strain, previously reported BoAHV 1.1 strains of India and Egypt. Genome identity of BoAHV-1.1 against BoAHV-1.2 was 97.70 to 98.70% for gD gene and 99.0 to 99.70% for gE gene respectively. The analysis highlights the higher genome identity among BoAHV-1 subtypes in the gE gene, suggesting its potential for developing more sensitive immunoassays for seroepidemiology. The developed assay could also be exploited for detecting BoAHV-5 infections. The findings contribute to the knowledge base essential for development of companion ELISA for implementing Differentiating Infected from Vaccinated Animals (DIVA) vaccination strategies.
Pengembangan Bahan Ajar E-Magazine dengan Pendekatan SAVI pada Materi Dinamika Litosfer dan Dampaknya Terhadap Kehidupan
Authors: Nurhasanah Nurhasanah , Handoyo Budi , Irawan Listyo Yudha
Published: September 2024

The development of 21st century education affects the use of learning media. In learning activities, digital teaching materials are needed that support the student's learning process. The development of e-magazine teaching materials for lithosphere dynamics materials is carried out because digital teaching materials are minimally used in learning. The purpose of this research is to produce e-magazine teaching materials with the SAVI approach. This study used the ADDIE (Analyze, Design, Development, Implementation, and Evaluation) model procedure. The types of data used are quantitative and qualitative. In the process of collecting data using questionnaires, interviews, as well as documentation of activities with percentage descriptive data analysis techniques.  Teaching material products are tested for feasibility at SMA Negeri 2 Malang class XI IPS 3.  Based on the results of product feasibility tests by media expert validators, material experts, linguists and test results in schools, e-magazine teaching materials are very feasible and valid for geography learning.
Project Based on Environment Learning dan Literasi Lingkungan dalam Kaitannya dengan Creative Thinking Skill
Authors: Salym Alya Qhutra Nada , Sumarmi Sumarmi , Soekamto Hadi , Osman Sharina
Published: September 2024

This research is a study using a project-based learning model on environment learning and its influence on creative thinking skills in terms of students' environmental literacy skills. This research was conducted to integrate the creative thinking ability of students with the level of environmental literacy of students who have a positive impact directly on the environment and society. This research has a posttest-only control group design and is a quasi-experiment. Students from SMAN 4 Sidoarjo's class 11 geography course participated as the study's subjects. The determination of experimental and control classes are carried out randomly. The result is that class 11 of Geo 3 specialization is selected as the experimental class while class 11 of Geo 2 specialization as the control class. Data collection using creative thinking ability test instruments and environmental literacy questionnaires. The Independent Sample T-Test and the Two Way Anova test were applied for the statistical analysis using the SPSS 26.0 version for Windows. The research revealed that (1) students' capacity for creative thought is positively impacted by the Project Based on Environment Learning model with a sig value. 0.003 0.05; (2) the project- based environmental learning model has a beneficial impact on students' capacity for original thought in terms of environmental literacy with sig values. 0.037 0.05.
Doğu Akdeniz Bölgesinde örtüaltı ve açık alanda yetiştirilen bazı incir çeşitlerinin erkencilik, verim ve meyve kalite özelliklerinin karşılaştırılması
Authors: Çalışkan Oğuzhan , Kılıç Derya , Beyazit Safder , Şen Fatih
Published: September 2024

Amaç: Bu çalışma, Doğu Akdeniz Bölgesinde örtüaltında ve açık alanda yetiştirilen Bursa Siyahı ve Nazareth incir çeşitlerinin verim ve meyve kalite özelliklerini karşılaştırmak amacıyla 2020 ve 2021 yıllarında sürdürülmüştür.
Materyal ve Yöntem: Çalışmada örtüaltında ve açıkta yetiştirilen çeşitlerde, bazı fenolojik, verim ve meyve kalite özellikleri incelenmiştir. Ayrıca meyvelerin kabuk ve et rengi L*, a* ve C* değeri olarak belirlenmiştir.
Araştırma Bulguları: Örtüaltı yetiştiriciliğin Bursa Siyahı çeşidinde 10 ile 13 gün, Nazareth çeşidinde ise 10 günlük bir erkencilik sağladığı belirlenmiştir. Bursa Siyahı çeşidinde en yüksek meyve ağırlığı açık alandan (65.19 g) elde edilirken, Nazareth çeşidinde örtüaltından (36.50 g) elde edilmiştir. Nazareth çeşidinin suda çözünebilir toplam kuru madde miktarı (SÇKM) içeriği hem örtüaltında (%21.07) hem açık alanda (%22.17), Bursa Siyahı çeşidinden (sırasıyla, %20.73 ve %20.54) daha yüksek bulunmuştur. Örtüaltında yetiştirilen Bursa Siyahı çeşidinde, 2020 ve 2021 yıllarındaki dekara verim değerleri (sırasıyla, 0.164 ton/da ve 0.394 ton/da) açık alana göre (sırasıyla, 1.667 ton/da ve 2.257 ton/da) daha düşük bulunmuştur.
Sonuç: Bursa Siyahı ve Nazareth çeşitlerinin iyilop ürünlerinin örtüaltı yetiştiriciliğinde erkenci yetiştiricilik için önemli avantajlar sağladığı, bununla birlikte daha uzun süreli araştırma sonuçları ile daha net sonuçlar elde edilmesi gerekmektedir.
Selection of succulent species to be used on green roofs according to phytogeographic regions: Türkiye example
Authors: Aksoy Onur , Erken Kamil
Published: September 2024

The objective of this study was to determine the succulent plant species that can be used on green roofs to be recommended for 3 phytogeographic regions in Türkiye.
Three phytogeographic regions in Türkiye and the succulent taxa found in the natural flora of these regions were chosen as the study material. In the study, firstly, literature search was conducted. Then, family, endemism, hairiness, climate, altitude and habitat status of succulent species obtained from the literature were determined. In line with the information obtained in the last stage, taxa that can be recommended for green roofs in 3 different phytogeographic regions are listed.
As a result of the study, it was determined that Saxifraga spp. and Sempervivum spp. in cool climates, Umbilicus spp. and Rosularia spp hot climates that the genera are the genera with the highest number of taxa. Also, ranked in both cool and warm climates, Sedum spp. and Rosularia spp. first in terms of the species richness of its genera
The findings of this study are of importance in terms of helping the selection of the right succulent species that can be used on green roofs for countries located in similar phytogeographic regions around the world.
Immersion into professional tests: cross-functional teams methodology
Authors:   Kuban State University, Mosina Oksana A.
Published: September 2024

The research purpose is to develop a methodology for early professionalization (professional tests), which will allow the process of professional development to be brought from a state of uncertainty to a purposeful process, effectively implemented in practice. The relevance of the presented research is dictated by the need to make the right professional choice at the beginning of life – during schooling. Until now, to solve this issue modern youth relied rather on a number of social stereotypes and financial trends than on objective professional priorities. The author's study is based on the me-thodology of modern professional education. The research presents theoretically substantiated results of critical analysis and systematization of social and pedagogical theories, as well as experimental studies. The result of the conducted system analysis is the development of a methodology for cross-functional teams in the education system. Implemented in the learning process the methodology will contribute to the elimination of outdated educational methods and tools, as well as the development of new adaptive methods of working with students. This methodology will provide senior students with a unique opportunity to expand their professional horizons and try themselves in various fields of activity. Participation in a cross-functional team also provides an opportunity to receive recommendations on the formation of a further professional trajectory. The originality of the proposed methodology lies in the fact that it can be used not only for conducting a private study, but also in the pedagogical process as a whole, covering the entire spectrum of pedagogical innovations at various levels of the education system.
Self-perceived oral health and happiness
Authors: Cademartori Mariana Gonzalez , Karam Sarah Arangurem , Chisini Luiz Alexandre , Collares Kauê Farias , Azevedo Marina Sousa , Demarco Flávio Fernando , Correa Marcos Britto
Published: September 2024

In recent years, studies investigating psychological states such as happiness in individuals’ health have increased. Aim: This study investigated a possible association between self-perceived oral health and happiness in university students. Methods: This cross-sectional study was performed in a cohort of university students who entered in the 2016 academic year at the Federal University of Pelotas, located in southern Brazil. Data were collected using a self-administered questionnaire, including demographic and socioeconomic characteristics, psychosocial traits, and oral health-related questions. Happiness was measured through a question accompanied by the Faces Scale of Andrews and Whitey. Poisson regression models with robust variance were used to assess the association between the exposure variables (oral health measures) and the outcome (happiness). Results: The prevalence of happiness was 48.6%. A significant association between happiness and oral health, including satisfaction with dental appearance (PR 1.86; 95% CI 1.73-2.01), oral health-related to quality of life (PR 1.19; 95% CI 1.09-1.31), and halitosis (PR 1.10; 95% CI 1.01-1.20), was found. Conclusion: Individuals who reported dissatisfaction with dental appearance, an impact on oral health-related to quality of life, and halitosis perceived themselves as unhappy.
Centralidade urbana e serviços de saúde: o município de Araguaína - TO
Authors: Nathália Canêdo de Lima Silva
Published: September 2024

Este trabalho traz uma investigação sobre a influência da localização dos serviços de saúde na constituição de centros e centralidades urbanas no espaço intraurbano, considerando também a sua organização dentro da rede de cidades, trazendo como estudo de caso a cidade de Araguaína – TO. Considera-se relevante compreender como estes serviços atuam e influenciam na produção do espaço urbano, tornando-se objetos estruturantes da cidade e capazes de fomentar processos de reestruturação das centralidades urbanas. O estudo de caso de Araguaína se justifica pelo aumento significativo em quantidade e importância da oferta de serviços de saúde notado nessa cidade através de pesquisas de Regiões de Influência de Cidades realizadas pelo IBGE nos anos de 2007 e 2018, e pela percepção de haver poucos estudos desse impacto na escala intraurbana. Dessa forma, através de métodos mistos (quantitativos e qualitativos), buscou-se compreender como a conformação dos serviços de saúde no Estado do Tocantins e na cidade de Araguaína atuam na dinâmica da constituição de centros e centralidades.
Kepesertaan Wajib Badan Penyelenggara Jaminan Sosial dalam Perspektif Hukum Persaingan Usaha
Authors: Pratiwi Galuh
Published: September 2024

This study highlighted the issue of arrangement for mandatory BPJS (Indonesian national health insurance) membership from the perspective of competition law. The research method used in this study was the normative juridical method, and the statute approach was employed. The results of the study indicated that the establishment of BPJS was mandated by the Law on National Social Security System (UU SJSN) and Law on National Health Insurance (UU BPJS); therefore, BPJS arrangement for mandatory membership is a permissible form of monopoly. The government monopoly through BPJS in administering health insurance is an obligation, instead, because the contribution of social security is in fact the same as taxes.Keywords: BPJS mandatory membership; competition law Penelitian ini mengangkat permasalahan mengenai pengaturan kepesertaan wajib BPJS dalam perspektif hukum persaingan usaha. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis normati. Pendekatan yang dipergunakan dalam penelitian adalah pendekatan perundang-undangan (statute approach). Hasil penelitian menunjukkan bahwa pembentukan BPJS merupakan amanat UU SJSN dan UU BPJS, sehingga pengaturan BPJS mengenai kepesertaan wajib BPJS merupakan bentuk monopoli yang diperbolehkan. Monopoli pemerintah lewat BPJS dalam penyelenggaraan jaminan kesehatan justru bentuk keharusan karena kontribusi jaminan sosial sesungguhnya sama dengan pajak.Kata-kata Kunci: Kepesertaan wajib BPJS; hukum persaingan usaha
Politik Hukum Eksekusi Putusan Mahkamah Konstitusi Di Indonesia
Authors: Christia Adissya Mega , Wardhani Lidya Christina , Tristy Marsatana Tartila , Surya Faizal Adi
Published: September 2024

The Constitutional Court is the only state institution that can carry out constitutional review of regulations and the result is expressed through a decision. The decision of the Constitutional Court is final and binding and at that time the principle of erga omnes applies where the legal force of the Constitutional Court's decision applies to anyone, not just limited to the parties involved in the case. This research aims to analyze the legal politics of 4 (four) Constitutional Court Decisions based on their nature and principles and shows their urgency. The approach method used is normative juridical with descriptive analysis. The results of this research are that the legal politics of executing Constitutional Court decisions has not yet been implemented because in reality there are still situations where decisions are not in harmony with statutory regulations, returning to statutory regulations before amendments, not followed by new and complicated statutory regulations. to be implemented. The legal political urgency of executing Constitutional Court decisions must return to the principle of final and binding nature as well as the principle of erga omnes, one of which is through ab initio confirmation if the decision is not complied with by other state institutions.Keywords: Constitutional Court, Constitutional Court Decision, Political Law
AbstrakMahkamah Konstitusi adalah satu-satunya lembaga negara yang dapat melakukan uji konstitusional terhadap undang-undang dan hasilnya dinyatakan melalui putusan. Putusan Mahkamah Konstitusi bersifat final dan mengikat (binding) serta pada saat itu pula berlaku asas erga omnes di mana kekuatan hukum Putusan Mahkamah Konstitusi berlaku pada siapa saja, tidak hanya terbatas berlaku bagi para pihak yang berperkara. Penelitian ini bertujuan menganalisis politik hukum dari 4 (empat) Putusan Mahkamah Konstitusi berdasarkan sifat dan asas serta menunjukkan urgensinya. Metode pendekatan yang digunakan adalah yuridis normatif dengan analisis deskriptif. Hasil dari penelitian ini adalah politik hukum eksekusi Putusan Mahkamah Konstitusi belum berjalan sebab pada kenyataannya masih terdapat keadaan di mana putusan tidak harmonis dengan peraturan perundang-undangan, kembali pada peraturan perundang-undangan sebelum amandemen, tidak diikuti oleh peraturan perundang-undangan yang baru dan rumit untuk dilaksanakan. Urgensi politik hukum eksekusi Putusan Mahkamah Konstitusi harus kembali kepada prinsip sifat final dan mengikat (binding) serta asas erga omnes salah satunya melalui penegasan ab initio apabila putusan tidak dipatuhi oleh pihak lembaga negara lain.Kata Kunci: Mahkamah Konstitusi, Politik Hukum, Putusan Mahkamah Konstitusi
Konstitusionalitas Peraturan Menteri Dalam Negeri: Studi Terhadap Peraturan Menteri Dalam Negeri Nomor 4 Tahun 2023 Tentang Penjabat Gubernur, Penjabat Bupati, Dan Penjabat Wali Kota
Authors: Taufiqurrahman
Published: September 2024

This research focuses on implementing regulations on the appointment of acting regional heads. This focus is motivated by content material that is not in line with the constitutional mandate. This is evidenced by the improper format of the arrangement, not containing a firm prohibition for the TNI/Polri to be appointed as acting, and the lack of involvement of the DPRD as a representative of the people in appointing acting regional heads. Based on these problems, this study answers the research question, namely whether the implementing regulations for filling the acting regional head are in accordance with the constitutional mandate? This research method is juridical normative through the approach of constitutional court decisions, laws and regulations and case approaches. The study concluded that the content material governing the appointment of acting regional heads is far from the constitutional mandate. The government has ignored the legal considerations established by the Constitutional Court in the context of appointing acting regional heads.Keywords: Acting, Constitutional Mandate, and Implementing Regulations.
AbstrakPenelitian ini berfokus pada peraturan pelaksana Menteri Dalam Negeri Nomor 4 tahun 2023 tentang Penjabat Gubernur, Penjabat Bupati, dan Penjabat Wali Kota Penelitian ini dilatarbelakangi dari materi muatan yang tidak sejalan dengan mandat konstitusional. Hal ini dibuktikan dengan format pengaturan yang tidak tepat, tidak memuat larangan tegas bagi TNI/Polri untuk ditunjuk sebagai penjabat, dan minimnya keterlibatan DPRD sebagai representasi rakyat dalam penunjukan penjabat kepala daerah. Berdasarkan persoalan tersebut, penelitian ini menjawab pertanyaan penelitian yakni apakah peraturan pelaksana pengisian penjabat kepala daerah telah sesuai dengan mandat konstitusional? Metode penelitian ini yuridis normatif melalui pendekatan peraturan perundang-undangan dan pendekatan kasus. Temuan dalam penelitian ini bahwa materi muatan yang mengatur penunjukan penjabat kepala daerah jauh dari amanat konstitusional. Pemerintah telah mengabaikan pertimbangan hukum yang dibangun oleh Mahkamah Konstitusi (MK) dalam rangka penunjukan penjabat kepala daerah. Adapun saran dalam penelitian ini pembentuk undang-undang untuk segera membentuk ragam klasifikasi tindaklanjut putusan MK. Kata Kunci: Mandat Konstitusional, Penjabat, dan Peraturan Pelaksana.
Mamilice kao prodavanje magle
Authors: Lechpammer Stela , Kanižaj Igor , Beck Boris
Published: September 2024

U ovom su radu prikazani stavovi hrvatskih novinara i urednika o mamilicama na temelju po‎lustrukturiranih intervjua provedenih 2023. godine s urednicima i novinarima trojih najčitanijih hrvatskih ‎dnevnih novina, koje imaju i svoje mrežne portale – Jutarnji list, Večernji list i 24sata. Istraživanje je poka‎zalo kako su financijska nužnost i povećanje dosega mrežnog izdanja glavni razlozi korištenja mamilica, ‎pri čemu je kod urednika i novinara naglašena funkcija privlačenja naslova, a zanemaren njegov infor‎mativni aspekt. Tu praksu novinari i urednici opravdavaju time da senzacionalizam naslova ne može ‎zasjeniti kvalitetne članke, no pokazalo se da ne percipiraju opasnost toga što mamilice često vode i na ‎bezvrijedne sadržaje. Dio urednika i novinara ipak smatra da prodavanje magle, kako se može okarak‎terizirati jezični modus mamilica, može biti dugoročno štetno za medij, unatoč evidentnoj neposrednoj ‎f‎ inancijskoj koristi. Istraživanje je ukazalo i na važan problem primjene različitih standarda u uređivanju ‎članka koji je otisnut u tiskanom izdanju, a potom modificiran mamilicama u elektroničkom izdanju, ne ‎uvijek uz odobravanje autora.‎
The emergence of digital ‎humanitarian actions
Authors: Bežovan Mijo , Karlović Antonio , Mihaljinec Robert
Published: September 2024

The COVID-19 pandemic greatly affected interpersonal relationships globally. Furthermore, ‎in 2020, Croatia was hit by devastating earthquakes that triggered a series of humanitarian actions. This ‎paper deals with the ‘Let’s bring the premature babies back to Petrova hospital’ Facebook group and its ‎auctioning model. The auctions were created through cooperation of the Facebook group members and, ‎as such, have not been described in scientific literature. The aim of this paper is to understand what the ‎case can tell us about cooperation in the digital environment and its role in creating digital humanitarian ‎actions. Using a mixed-methods approach, the authors analyze posts published by Facebook group ‎members and interviews conducted with organizers to explain the phenomenon of strengthening the ‎existing connections among participants and undertaking a collective action. This case indicates that ‎digital activism does not necessarily result in pure slacktivism. In point of fact, transparent participation ‎of community members, along with a transparent model, can have tangible effects on society through ‎successful humanitarian actions‎
Urban Ecology of Red-Whiskered Bulbul: Feeding Behavior, Breeding Success and Behavioural Patterns in New Barrackpore, West Bengal, India
Authors: Mallick Md. Abu Imran , Biswas Nirdesha
Published: September 2024

This study investigates the urban ecology of the Red-Whiskered Bulbul (Pycnonotus jocosus) in New Barrackpore, West Bengal, India. We examined the feeding behavior, breeding success, and behavioral patterns of the species in urban habitats. Our results show that the Red-Whiskered Bulbul is adapting to urban environments, with a moderate breeding success rate (64%) and specific behavioral patterns. The species exhibits a significant preference for urban habitats, particularly mango and bamboo trees, and a significant increase in singing activity during the breeding season. Our findings highlight the importance of urban ecology in understanding the behavior and conservation of this species. We suggest that urban green spaces with native tree species and sustainable urban planning practices can support the conservation of the Red-Whiskered Bulbul and other urban-adapted species. This study contributes to our understanding of urban wildlife ecology and conservation in India and has implications for urban planning and biodiversity conservation globally.
A Survey System for Artificial Intelligence-Based Painting Using Generative Adversarial Network Techniques
Authors: Jean Ming-Der , Zhang Chaoyang , Li Xiang
Published: September 2024

The purpose of this paper is to construct an evaluation system for AI painting software based on generative adversarial network technology, which optimizes the performance of the related software in terms of functionality, ease of use, system performance and safety. The results of the questionnaires are statistically analyzed. In addition, exploratory factor analysis was supported to extract the data of the study, which was ultimately used to calculate the weight and importance of each index through fuzzy hierarchical analysis method. The study constructed an evaluation system for AI painting software based on generative adversarial network technology, including 16 indicators of functionality, 16 indicators of ease of use, 7 indicators of system performance, and 8 indicators of safety respectively that their alpha coefficients were 0.882, 0.962, 0.932, 0.932, and 0.932, respectively. In addition, the accumulated explanatory variances of their coefficients were 84.405%, 84.897%, 84.013%, and 72.606%, respectively, 73.013%, and 72.606%, respectively. It is clear that the items included in each of the indicators are homogeneous, with a high degree of internal consistency. This paper suggests that the development of AI painting software focusing on functionality, ease of use, system performance and safety can enhance the market competitiveness of the software.
Platelet Responses after Tapering and Discontinuation of Fostamatinib in Patients with Immune Thrombocytopenia: A Continuation of the Fostasur Study
Authors: Mingot-Castellano Maria-Eva , Garcia-Donas Gloria , Campos-Alvarez Rosa Maria , Fernández-Sánchez de Mora Maria Carmen , Luis-Navarro Josefa , Domínguez-Rodriguez Juan Francisco , Nieto-Hernandez Maria del Mar , Sánchez-Bazán Irene , Yera-Cobo Maria , Cardesa-Cabrera Rocio , Jímenez-Gonzalo Francisco Jose , Caparrós-Miranda Isabel , Entrena-Ureña Laura , Jurado-Herrera Sergio , Fernández Jimenez Dolores , Díaz-Canales Dana , Moreno-Carrasco Gloria , Calderón-Cabrera Cristina , Nuñez-Velazquez Ramiro Jose , Pedrote-Amador Begoña , Jiménez-Bárcenas Reyes
Published: September 2024

Fostamatinib is a spleen tyrosine kinase (SYK) inhibitor approved for the treatment of adult patients with chronic immune thrombocytopenia (ITP). There is little information about dose tapering and sustained remission after discontinuation in ITP. In this retrospective, multicenter study we evaluated efficacy and safety of fostamatinib in adult patients with ITP before, during and after tapering/discontinuation (T/D). T/D was performed in subjects who achieved complete platelet response (CR) with progressive, conditional dose reduction dose every 4 weeks. Sixty-one patients were included at 14 reference centers between October 2021 and May 2023. In subjects that completed T/D (n=9), median time from treatment initiation to response was 21 days (IQR:7.5-42), time to CR 28 days (IQR:28-42), time to start tapering 116 days (IQR: 42-140), duration of tapering 112.5 days (IQR 94.5-191). Median platelet count at tapering was 232×109/L (IQR 152-345×109/L) and at discontinuation 190×109/L (IQR 142.5-316.5×109/L). With a median follow-up since discontinuation of 263 days (IQR: 247-313 days), only two patients have relapsed (at 63 and 73 days. Fostamatinib was restarted, achieving a new CR. Platelet counts higher than 100x109/L at week 12 was the only positive predictive factors for successful tapering and discontinuation.
Integration of AI in the Banking Sector
Authors: Sardauna Abdul-sobur , Ali Arif
Published: September 2024

The modern world is gradually moving towards a global civilisation that is automated and propelled by technology. Artificial intelligence (AI) is a highly advanced technology that has been acknowledged as a major innovation. The incorporation of this technology into the banking sector has enhanced operational procedures in relation to customer satisfaction, virtual assistance, and risk reduction. This machine is employed to streamline activities and improve how decisions are made in this sector. This study investigates the potential benefits and challenges of implementing artificial intelligence in the banking sector. The methodology ensures a comprehensive understanding of the implementation of artificial intelligence in banking by showcasing its effectiveness, precision, and efficiency, as well as the opportunities it presents. The study data were collected from secondary sources, such as recent publications that demonstrate applications of artificial intelligence from five different banks, as well as the examination of industry reports. The main findings of this study demonstrate the substantial improvement of administrative operations through AI-driven technology, which effectively automates activities that include inputting data and handling information. As a result, the frequency of mistakes caused by people has reduced, leading to a 30% decrease in operational expenditures for all evaluated institutions. However, the banking industry admits the challenges it encounters, such as issues with confidentiality and a scarcity of skilled employees. In the financial services industry, the integration of artificial intelligence into the banking sector is perceived as an advantageous chance instead of a harmful danger, with a greater potential for beneficial impact.
A Comprehensive Overview of The Principles, Design, Operation, And Optimization of a Three-Bed TSA Dryer for Hydrogen Gas Dehydration
Authors: Islam Md. Mirazul
Published: September 2024

Dehydration of hydrogen gas is one of the important steps in many industrial purposes thus, drying systems have been developed with high-efficiency and relative effect. In this article, the basic principles and design of a three-bed TSA (Temperature Swing Adsorption) dryer for dehydration operation of hydrogen gas drying are described in detail. The text commences with an in-depth explanation of the basic principles behind TSA technology such as adsorption and desorption mechanisms, thermodynamic considerations and material selection for adsorbents. This paper also deals with the detailed design of a three-bed TSA dryer, explaining about various fabricating details that influences both performance and total operability. The third part focuses the operational phase, and especially in cycle time, regeneration strategy and efficiency of energy. Advanced optimisation techniques are employed to lower energy consumption, increase throughput capacity and improve overall system. This detailed study will be of great help for engineers and investigators working on TSA systems design and optimization to dehydrate hydrogen gas, contributing towards the betterment in this important field dealing with industrial gas processing.
Sanger Sequencing Revealed Borrelia burgdorferi with FlaB Paralogs Causing Spirochetemia in Early Localized Lyme Disease
Authors: Lee Sin Hang
Published: September 2024

It is generally assumed that spirochetemia does not take place at the early localized stage of Lyme disease. This misassumption is due to the lack of sensitive and specific methods for detection. This paper reports that separation of the platelet-rich plasma immediately after venous blood collection to prevent the spirochetes from invading the lymphocytes in the test tube is crucial in molecular detection of a single Borrelia burgdorferi cell spun down in platelet pellets. In 2023, we tested the venous blood specimens of 145 people residing in Lyme disease-endemic areas in the United States. In 98 of them, who were suspected of having early localized Lyme disease irrespective of the absence or presence of a skin lesion, we found 33 specimens (33.7%) positive for B. burgdorferi, including 17 positive for FlaB gene only, 15 positive for both FlaB gene and 16S rRNA gene, and 1 positive for 16S rRNA gene only. Eight (17.0%) of the 47 asymptomatic resident controls were positive for FlaB PCR only. FlaB is a more sensitive chromosomal target than the 16S rRNA gene for the detection of 1-3 B. burgdorferi cells in 1 mL of platelet-rich plasma due to spirochetes gaining or retaining FlaB paralogs at the early localized stage of Lyme disease.
Alternative Slope-Deflection Equations for Static Analysis of Indeterminate Structures
Authors: Lavadiya Dayakar Naik , Garcia Eric Vincent , Pankratz Clare M , Kalthoff Kristine M
Published: September 2024

This paper provides an alternative Slope-Deflection equation for performing the static analysis of the indeterminate structures. While the conventional Slope-Deflection method introduced in undergraduate structural analysis course involves the use of fixed end moments in the Slope-Deflection equations, the proposed method employs the slope of a simply supported beam to obtain the unknown moments at the joints. Three numerical examples of continuous beams with different load configurations are chosen and the efficacy of the proposed equations is demonstrated. From the perspective of undergraduate structural analysis course in Civil Engineering education, the approach proposed in this paper offers two advantages: (1) prior knowledge of fixed beams is not required and (2) the concepts gained from determinate structural analysis are directly applicable.
Evaluating the Impact of Fed and Domestic Monetary Policies on Long-Term Government Bond Yields
Authors: Gottimukkala Srinivas Raju
Published: September 2024

This paper investigates the secular decline in real interest rates and the potential influence of central bank monetary policy on long-term government bond yields, focusing particularly on the US Federal Reserve (Fed). While various demand-side and supply-side explanations, such as ageing populations, lack of investment opportunities, and reduced productivity growth, have been proposed for this decline. A recent study highlighted the significant role of 3-day time windows around Federal Open Market Committee (FOMC) meetings in capturing yield changes in 10-year Treasuries. To explore if similar patterns exist in other advanced economies, this study constructs 3-day monetary policy decision windows around the 10-year government bond yields for selected countries, using both domestic central bank decision dates and those of the Fed. The findings suggest that, despite heterogeneity among advanced economies and factors like unconventional monetary policy tools and exchange rate interventions, there is substantial evidence supporting a stronger influence of the Fed's decisions on global bond yields compared to national monetary policies. By employing a simple Ordinary Least Squared (OLS) method to analyze the covariance between bond yields and policy decisions, this study establishes a connection between the literature on the global financial cycle and secular stagnation. The results imply that the Fed's influence extends beyond US borders, potentially contributing to a global monetary policy dynamic.
The Therapeutic Target of SGLT2 Inhibitors and GLP-1 Agonists Is Superoxide Induced Diuretic Resistance
Authors: Kaesemeyer MD Wayne
Published: September 2024

Diuretic resistance is a servomechanism involving superoxide that results from the
use of escalating doses of diuretics in the treatment of heart failure. Without intervention this
may lead to increased heart failure mortality. Recent heart failure studies involving the use of
SGLT2 inhibitors and GLP-1 agonists have shown reductions in the need for loop diuretics
along with reductions in hospitalizations for heart failure and cardiovascular mortality. Multiple
mechanisms have been proposed to explain the benefits of both these drug classes but this
paper is the first to explain and propose superoxide induced diuretic resistance as a therapeutic
target for the treatment of heart failure.
Cultivating Health: Advancing Medicinal Plant Management Strategies in Iraq
Authors: Jumaa  Alsalahi Mahir Essa
Published: September 2024

From ancient Mesopotamia, medicinal plants have been important to human health. Their use in Iraq is traced back to early cuneiform tablets and relies on local flora for health advantages. Despite its rich history, Iraq confronts environmental deterioration, socio-political instability, and insufficient research resources that threaten plant sustainability.
Modern medicine employs Iraqi and worldwide plants. Illegal business and weak policies hinder resource management.
Medical plants, worldwide business, offer Iraq economic promise. Land and water management and value-added product development may boost the economy. The assessment recommends better market analysis and policymaking to promote sustainability and economic growth.
Traditional healers, academics, and governments must work together to conserve Iraq's medicinal plant history and improve health. Research and community engagement will preserve these resources by integrating traditional and modern science.
Research on Multi-Modal Music Score Alignment Model for Online Music Education
Authors: Ren Dexin
Published: September 2024

As music data storage becomes increasingly diverse in the era of big data, ensuring alignment of music works with the same semantics for online music education is crucial. To achieve this, a multi-modal music score alignment algorithm model based on deep learning was developed and optimized. Experimental results demonstrated that Note + DCO feature combination yielded the best MIDI input characteristics (mean value: 13.27 ms), whereas CQT feature comparison produced the best results for audio input (average: 12.85 ms). The ResNet-34 network was noted to have the most effective music score alignment effect with alignment errors averaging less than one frame. Compared with other algorithms, the proposed algorithm had the lowest average value of 9.28 ms, median value of 5.85 ms, and standard deviation of 20.17 ms. Actual music retrieval showed a Top-1 retrieval accuracy of 10.93% that was close to 11%. Overall, the proposed algorithm is significant for score alignment and music retrieval recognition in online music education.
COMBINED SUPERCHARGING SYSTEM OF DOMESTIC HIGH-PRESSURE TWO-STROKE SPECIAL PURPOSE DIESEL
Authors: Savchenko A. , Shelestov M.
Published: September 2024

Modern trends in engine construction are inextricably linked to the improvement of power units by modernizing existing models. The introduction of a forced to 1100 kW diesel engine of the DN type allows to increase the efficiency and bring the equipment in line with modern requirements in a short time and with lower costs. The key method of improvement is the modernization of the supercharging system, which increases power without increasing the dimensions and weight of the engine, as well as improves technical and economic characteristics. A combined supercharging system with a low-pressure turbocharger (LPT) and a high-pressure drive compressor (HPT) is proposed, which work together or separately depending on the operating mode. The use of a mathematical model of the workflow made it possible to carry out a computational and experimental study of the proposed system in the modes of maximum power and maximum torque, confirming its high efficiency. The use of modern technologies and materials, as well as the introduction of innovative design and modeling methods, allows to create more reliable and durable power units. Modernization of the supercharging system is one of the most important directions in the development of modern engine construction, which allows to achieve an increase in the level of specific power, improvement of fuel economy and environmental characteristics of engines by ensuring optimal conditions for their operation in various operating conditions and in a wide range of operating modes. The paper presents the research results of the proposed two-stage supercharging scheme of the DN type diesel engine, which makes it possible to achieve a power of 1100 kW. It is shown that this scheme has advantages over the traditional one, as it makes it possible to provide a higher boost pressure in a wider range of crankshaft RPM, as well as to reduce power consumption from the crankshaft to drive the compressor at modes close to the nominal ones. These factors collectively lead to a significant improvement in the characteristics of the diesel due to the introduction of the two-stage supercharging system.
MODELING OF MIXTURE FORMATION IN A TWO-STROKE DIESEL ENGINE
Authors: Lal A.G. , Parsadanov I.V.
Published: September 2024

The Ukrainian engine industry played a significant role in the creation, production, and improvement of the efficiency of two-stroke diesel engines with opposed mooved pistons and providing them with the highest indicators of liter and overall power. The results of research carried out at the department of engines and hybrid power plants of NTU "KhPI" reveal existing reserves for further improvement, ensuring world-class indicators and forming promising characteristics of two-stroke diesel engines of the 6DN12/2x12 series. Further developments to ensure a new level of power cannot be implemented exclusively by updating auxiliary units and systems. To create a promising power plant, the problem must be considered in a complex with an understanding of the physical and chemical processes in the engine cylinder. The two-stroke cycle and design features limit the possibilities of conducting experimental studies of engines of this type, and make it necessary to determine reserves for increasing their efficiency. In this case, the dissemination of ideas about the course of mixture formation processes in a two-stroke engine with lateral fuel injection becomes an urgent scientific and practical task. Solving this problem makes it possible to determine the reserves of increasing combustion efficiency in engines with reciprocating movement of pistons. Based on the results of the research, a mathematical model is proposed that allows us to determine the most rational ways of organizing mixture formation, provided the conditions of uniform distribution of fuel in the volume of the combustion chamber are ensured. The obtained results of the calculated studies are the basis for the development of structural elements, further experimental studies and the implementation of measures to ensure the further improvement of the mixing efficiency of two-stroke diesel engines of the 6DN12/2x12 series and their modifications.
Challenges in Supporting Women's Recovery from Sexual Violence in a Village Setting: Addressing Social Structures in Gampong Meurandeh Dayah, Aceh
Authors: Rijal Syamsul , Nasir Mohd.
Published: September 2024

This article examines the structural challenges in the formation of advocacy policies for female victims of sexual violence in Gampong Meurandeh, Langsa City, Aceh. The data collection process utilized the participatory action research method over four months. Drawing upon social structure theory, the article argues that the causes of sexual violence in rural communities are not only rooted in knowledge and culture but also in the social structures that operate within these communities. The research findings indicate that the reluctance of village authorities to engage in the formulation of sexual violence policies is impeding the successful execution of sexual violence prevention programs. The article highlights two factors that hinder the prevention of sexual violence in Gampong Meurandeh Dayah. Firstly, the lack of female representation in the village government Secondly, support for victims of sexual violence is not a primary concern in the village government's policies. The article concludes that sexual violence prevention programs implemented in patriarchal communities require not only a change in public knowledge but also interventions at the structural level.
INSTILLING ENVIRONMENTAL AWARENESS AND NATURALISTIC INTELLIGENCE IN EARLY CHILDHOOD EDUCATION: A CASE STUDY OF A KINDERGARTEN IN INDONESIA
Authors: Kamil Nurhusni
Published: September 2024

Children should be exposed to character education at an early age. Naturalistic intelligence and environmental consciousness should be introduced and instilled early on. The 2013 Curriculum includes this love of nature as one of the components of religious and moral growth. In spiritual and ethical development, we learn about the value and respect for God’s creations as well as appropriate behavior toward other living beings, including plants and animals. The loving-nature mindset is integrated into the learning objectives of religious values and character in the Independent Curriculum (Kurikulum Merdeka). This study aims to describe the forms of nature-loving education in a kindergarten in Indonesia and the types of activities that children can engage in. This research employs a qualitative methodology with a case study approach. The population of this study consists of all 18 children in Kindergarten B. Data collection was conducted using observation and checklist assessment techniques, and data analysis followed the Miles and Huberman technique. The results indicate that children are more enthusiastic about visiting animal enclosures directly and creating crafts from recycled materials as part of fostering naturalistic intelligence and a love for nature.
Interlegality of Marriage Law: Tracing the Dynamics of Sumbong Marriages Practices in Jambi
Authors: Puspita Mega , Umami Khairul
Published: September 2024

This article departs from the interlegality of marriage laws in Jambi society today, which discusses sumbong marriages. Sumbong marriage itself is a marriage that is legal according to religion, state, and custom. However, the ability to marry sumbong itself is considered valid by carrying out a customary settlement first, which was initially prohibited by customary law. The prohibition on marriage in Indonesia is contained in Article 8 of Law Number 1 of 1974 concerning Marriage and Article 39 of the Compilation of Islamic Law. Departing from this phenomenon, the author tries to examine the writing, which includes the implementation of marriage law in the Jambi community, the legal pluralism of the Jambi community, and the interlegality of customary, religious and state law in the marriage law of the Jambi community. The type of research carried out by the author is field research (Field Research) with qualitative methods. The nature of this research is analytical descriptive research. The approach used by the authors is a sociological empirical approach with interlegality. The author's findings clearly show that legal interactions in this tradition involve interactions between several laws, including religious, state, and customary laws used in sumbong marriage practices. By applying the legal interlegality theory approach, customary law, state law, and religious law become one unit. The concept of interlegality is found in adopting the values contained in the sumbong marriage tradition, whether based on state law, Islamic law, or Jambi customary law. This adoption process is based on the characteristics of the Jambi community's legal identity and its social environment, which is still steeped in customs, and the community also upholds the norms that apply in society and adheres firmly to "adat basandi syarak, syarak basandi kitabullah. "