bluuebunny/crossref_metadata_2025 huggingface dataset:
"What exactly is a paedophile?" Children talking about Internet risk
Authors: Burn Andrew , Willett Rebekah
Published: March 2020

Reports tell us that the internet is opening new dangers to children, including online grooming, exposure to pornography and financial scams (Carr 2004; Gardner 2003; UK Home Office 2001; O'Connell 2003). The result has been various initiatives which attempt to teach children safe surfing habits. The UK Home Office “ThinkUKnow” campaign featured advertisements on the radio, internet and cinemas, targeting teens and preteens with the message that the person they are chatting to “may not be who you think they are”. There are indications that such campaigns have had an impact on children's awareness of “stranger danger” on the internet (Livingstone/Bober 2003). However, many organisations are still struggling with the question of how best to prevent internet-related harm to children.
Children are exposed not only to advertising campaigns about stranger danger but also sensationalist stories about, for example, what happens to girls who enter chat rooms. When a teenage girl goes missing, police investigations routinely include looking at the girls' online activities, and tabloid media frequently make the connection between missing school girls and chat room activities. These connections are firmly embedded in the minds of the children we interviewed for the study we will be discussing. Alongside the very rational and prohibitive discourse coming from campaigns which warn children against any chat with strangers, sit the folkloric stories about girls meeting up and getting killed by paedophiles. The challenge to educators is to find an approach which will engage with both sets of discourses.
Themenfelder der Medienpädagogik
Authors: Bachmair Ben
Published: March 2020

Schnell ist das Ziel der Medienpädagogik mit "Medienkompetenz" benannt. Wenn man die Geschichte der Medienpädagogik und Mediendidaktik durchgeht, dann ist mit dieser Zieldefinition schon eine Menge erreicht. Es ist ein Erfolg der Medienpädagogik als Disziplin, dass sich eine von Politik, Wirtschaft und Schule akzeptierte Zielvorstellung heraus kristallisiert hat. Reicht diese allgemeine Akzeptanz jedoch aus, um Medien als Bildungsaufgabe zu bestimmen? Will man sich der Bildungsaufgabe theoretisch wie praktisch stellen, dann geht es um nicht weniger als die Frage, wie Medien in das Verhältnis der Menschen zu sich, zu anderen, zur Kultur, zu den Dingen und Ereignissen vermittelnd eingreifen, vielleicht sogar Prägekraft entwickeln. Das Verhältnis der Menschen zu sich, zur sozialen, dinglichen und kulturellen Umwelt war und ist immer in Bewegung. In diesem Verhältnis entstanden und entstehen typische Formen von Subjektivität, verläuft Sozialisation. Subjektivität konstituiert sich immer in einem unstetigen Feld von subjektivem Innen und objektivem Außen, von individueller Erfahrung und institutioneller Festlegung, von vorgegebener Kultur und einmaliger Aneignung. Im Moment erleben wir dieses Feld als besonders unstetig. Deshalb die Frage, was sich aktuell verändert, um die für die Konstitution von Subjektivität, anders formuliert, um die für Bildung und Sozialisation maßgebliche Konstellation im Medienbereich zu entdecken. Vielleicht lassen sich so Themenfelder der Medienpädagogik neu akzentuieren. Deshalb einführend einige Stichworte zur kulturellen und gesellschaftlichen Entwicklung.
Über die (visuelle) Konstitution von Onlinediskursen und ihre empirische Untersuchung
Authors: Reißmann Wolfgang
Published: March 2020

Rezension zu Stefan Meier (Bild-)Diskurs im Netz Konzept und Methode für eine semiotische Diskursanalyse im World Wide Web Köln: Herbert von Halem, 2008. 480 Seiten ISBN: 978-3-938258-83-5
Existenz als holistischer Anspruch an (schulische) Lernorganisation – praxisorientierte Einblicke in eine Allianz von Schul- und Kulturpädagogik
Authors: Küllertz Daniela
Published: March 2020

Rezension zu Burkhard Hill, Tom Biburger und Alexander Wenzlik Lernkultur und Kulturelle Bildung. Veränderte Lernkulturen - Kooperationsauftrag an Schule, Jugendhilfe, Kunst und Kultur München: kopaed, 2008. 190 Seiten ISBN-13 978-3-86736-312-9
Medien als Bildungsressourcen
Authors: Lampert Claudia
Published: March 2020

Rezension zu Ulrike Wagner Medienhandeln in Hauptschulmilieus. Mediale Interaktion und Produktion als Bildungsressource München: koaed Verlag, 2008. 254 Seiten ISBN: 978-3-86736-054-8
Virtuelle Spielwelten
Authors: Peez Georg
Published: March 2020

Rezension zu Lars Zumbansen Dynamische Erlebniswelten Ästhetische Orientierungen in phantastischen Bildschirmspielen München: koaed Verlag, 2008. 247 Seiten ISBN: 978-3-86736-116-8
Theoretische und empirische Facetten des komplexen Beziehungsgeflechts Medienkultur und soziales Handeln
Authors: Hoffmann Dagmar
Published: March 2020

Rezension zu: Thomas, Tanja, Hrsg. 2008. Medienkultur und soziales Handeln. 1. Aufl. Medien - Kultur - Kommunikation. Wiesbaden: VS Verlag für Sozialwissenschaften.
Ein Paradigma, das es weiter zu konkretisieren gilt. Der Begriff der Mediatisierung bei Krotz
Authors: Kübler Hans-Dieter
Published: March 2020

Rezension zu: Krotz, Friedrich. 2007. Mediatisierung: Fallstudien zum Wandel von Kommunikation. 1. Aufl. Medien - Kultur - Kommunikation. Wiesbaden: VS Verlag für Sozialwissenschaften.
Annäherung an Alltagsästhetik und mobile media als letzte Chance für die Schule?
Authors: Kommer Sven
Published: March 2020

Rezension zu: Bachmair, Ben. 2009. Medienwissen für Pädagogen: Medienbildung in riskanten Erlebniswelten. 1. Aufl. Lehrbuch. Wiesbaden: VS Verlag für Sozialwissenschaften.
Die Aufführung von Sozialität – Theatermetaphorik als erkenntniskonstitutives Modell sozialen Wandels
Authors: Küllertz Daniela
Published: March 2020

Rezension zu: Herbert Willems (Hrsg.): Theatralisierung der Gesellschaft. Soziologische Theorie und Zeitdiagnose. Bd. 1 Wiesbaden: VS Verlag für Sozialwissenschaften, 2009. 631 Seiten ISBN-13 978-3-531-14922-6 und Herbert Willems (Hrsg.): Medientheatralität und Medientheatralisierung. Bd. 2 Wiesbaden: VS Verlag, 2009. 467 Seiten ISBN-13 978-3-531-14921-9
Jugendkulturen und medialer Wandel
Authors: Reißmann Wolfgang
Published: March 2020

Rezension zu: Hugger, Kai-Uwe, Hrsg. 2010. Digitale Jugendkulturen. 1. Aufl. Wiesbaden: VS Verlag für Sozialwissenschaften.
Ein kultiviertes Verhältnis
Authors: Bockermann Iris , Schelhowe Heidi
Published: March 2020

Rezension zu: Kommer, Sven. 2010. Kompetenter Medienumgang? Eine qualitative Untersuchung zum medialen Habitus und zur Medienkompetenz von SchülerInnen und Lehramtsstudierenden. Opladen Farmington Hills, MI: Budrich UniPress Ltd.
Körper im Film
Authors: Schorb Friedrich
Published: March 2020

Rezension zu: Hoffmann, Dagmar, Hrsg. 2010. Körperästhetiken: filmische Inszenierungen von Körperlichkeit. Film. Bielefeld: Transcript.
Migrantinnen machen Fotos und entdecken dabei sich selbst
Authors: Schwender Clemens
Published: March 2020

Rezension zu: Kulcke, Gesine. 2009. Identitätsbildungen älterer Migrantinnen: die Fotografie als Ausdrucksmittel und Erkenntnisquelle. 1. Aufl. VS research. Wiesbaden: VS Verlag für Sozialwissenschaften.
Cheating als Mehrwert – Kultur, Ökonomie, Macht
Authors: Ring Sebastian
Published: March 2020

Rezension zu: Consalvo, Mia. 2009. Cheating: Gaining Advantage in Videogames. Mass.; London. Cambridge: MIT Press.
Ein pädagogischer Synergieeffekt für Praxis und Theorie: Themenzentrierte Medienarbeit
Authors: Schmidt Theresa
Published: March 2020

Rezension zu: Keilhauer, Jan, und Bernd Schorb, Hrsg. 2010. Themenzentrierte Medienarbeit mit Jugendlichen: ein Modellprojekt mit deutschen und tschechischen Jugendlichen zum Thema Präimplantationsdiagnostik. München: Kopaed.
Das Kind als cinematische Figuration
Authors: Ruge Wolfgang B.
Published: March 2020

Rezension zu: Stewen, Christian. 2011. The cinematic child: Kindheit in filmischen und medienpädagogischen Diskursen. Marburger Schriften zur Medienforschung 29. Marburg: Schüren.
Mobile Learning
Authors: Petschenka Anke
Published: March 2020

Rezension zu: de Witt, Claudia, und Almut Sieber, Hrsg. 2013. Mobile Learning: Potenziale, Einsatzszenarien und Perspektiven des Lernens mit mobilen Endgeräten. Wiesbaden: Springer VS.
Digitale Medien, freie Bildung und vernetztes Wissen
Authors: Stollfuß Sven
Published: March 2020

Rezension zu: Petra Missomelius, Wolfgang Sützl, Theo Hug, Petra Grell und Rudolf Kammerl, Hrsg. Medien – Wissen – Bildung: Freie Bildungsmedien und Digitale Archive. Innsbruck: innsbruck university press, 2014
Social Media kompakt betrachtet
Authors: Junge Thorsten Olaf
Published: March 2020

Rezension zu: Jan-Hinrik Schmidt: Social Media. Wiesbaden: Springer VS, 2013
Entgrenzung aus zwei Perspektiven: Jugendforschung und Medienpädagogik
Authors: Stingel-Voigt Yvonne
Published: March 2020

Becker, Ulrike, Henrike Friedrichs, Friederike von Gross, und Sabine Kaiser, Hrsg. 2016. Ent-Grenztes Heranwachsen. Wiesbaden: Springer Fachmedien Wiesbaden.
Mediendiskursanalyse als multiperspektivisches Unterfangen
Authors: Dander Valentin , Bettinger Patrick
Published: March 2020

Rezension zu: Dreesen, Philipp, Łukasz Kumięga, und Constanze Spieß, Hrsg. 2012. Mediendiskursanalyse. Diskurse - Dispositive - Medien – Macht. Wiesbaden: VS Verlag für Sozialwissenschaften. doi:10.1007/978-3-531-93148-7.
Das Dispositiv als Bindeglied einer interdisziplinären Medienbildungsforschung
Authors: Bettinger Patrick , Dander Valentin
Published: March 2020

Rezension zu: Othmer, Julius, und Andreas Weich, Hrsg. 2015. Medien – Bildung – Dispositive. Beiträge zu einer interdisziplinären Medienbildungsforschung. Wiesbaden: Springer Fachmedien Wiesbaden. doi:10.1007/978-3-658-07186-8.
Laudatio: Alphabetisierung als Aufgabenfeld der Medienpädagogik
Authors: Moser Heinz , Spanhel Dieter
Published: March 2020

Laudatio zur Verleihung des Promotionspreises der Sektion Medienpädagogik in der Deutschen Gesellschaft für Erziehungswissenschaft am 21.9.2017 in Magdeburg. Koppel, Ilka. 2017. Entwicklung einer Online-Diagnostik für die Alphabetisierung. Eine Design-Based Research-Studie. Wiesbaden: Springer Fachmedien Wiesbaden. https://doi.org/10.1007/978-3-658-15769-2.
Die Politische Ökonomie von Social Media durchdringen
Authors: Dander Valentin
Published: March 2020

Rezension zu: Fuchs, Christian. 2017. Social media: a critical introduction. 2nd edition. Thousand Oaks, CA: SAGE Publications.
Neue medienpädagogische Konzepte für das Leben in einer digital geprägten Welt
Authors: Ullrich Annette , Trabandt Sven , Stoltenhoff Ann-Kathrin , Raudonat Kerstin
Published: March 2020

Rezension zu:

Brüggemann, Marion, Thomas Knaus, und Dorothee M. Meister, Hrsg. 2016. Kommunikationskulturen in digitalen Welten: Konzepte und Strategien der Medienpädagogik und Medienbildung. Schriften zur Medienpädagogik 52. München: kopaed.
Neue Theorieoptionen für die Medienbildung
Authors: Bettinger Patrick
Published: March 2020

Rezension zu:

Allert, Heidrun, Michael Asmussen, und Christoph Richter, Hrsg. 2017. Digitalität und Selbst: interdisziplinäre Perspektiven auf Subjektivierungs- und Bildungsprozesse. Pädagogik. Bielefeld: Transcript.
Open Education: Von Begriffsbestimmungen hin zur Anforderung an Gegenwartsdiagnosen im Kontext Openness
Authors: Hofhues Sandra
Published: March 2020

Rezension zu:
Deimann, Markus. 2018. Open Education. Auf dem Weg zu einer offenen Hochschulbildung. Bielefeld: transcript
Monetary Policy Shocks and Manufacturing Output in Nigeria (1981-2018)
Authors: Hammed Yinka Sabuur
Published: March 2020

This study empirically investigates the impact of monetary policy shock on the manufacturing output in Nigeria using time series data covering the period between 1981 and 2018. Co-integration test was used to establish the long run relationship among the variables and Structural Vector Auto-Regressive model was employed to test for the shocks. It was found that shock to broad money supply would bring about positive and significant impact on the manufacturing output while the impact of shock to interest rate was found to be negative and insignificant. This study however concludes that shock to broad money is the main monetary policy instrument which can bring about positive change to manufacturing output in Nigeria. This paper then suggests that government and policy makers should primarily focus on this variable in their implementation of unanticipated monetary policy.
Distribución potencial de Abies vejarii (Pinaceae) y su relación con factores ambientales, topográficos y antropogénicos en el noreste de México.
Authors: González-Cubas Rigoberto , Treviño-Garza Eduardo Javier , Aguirre-Calderón Oscar Alberto , Foroughbakhch-Pournavab Rahim
Published: March 2020

Antecedentes y Objetivos: Abies vejarii (oyamel) es una especie endémica del noreste de México, actualmente catalogada como Casi Amenazada por la Unión Internacional para la Conservación de la Naturaleza (UICN), con poblaciones aisladas. Los objetivos del presente estudio fueron i) buscar áreas en donde se reúnan las condiciones ideales para el desarrollo del oyamel utilizando el algoritmo de máxima entropía en la Sierra Madre Oriental (SMOR), ii) identificar las variables ambientales topográficas asociadas a su distribución actual y iii) evaluar los impactos antropogénicos actuales en la distribución de A. vejarii.
Métodos: Mediante un modelo de distribución de especie (MDE), se modeló la idoneidad de su hábitat, utilizando datos bioclimáticos y topográficos. Se identificaron las variables ambientales que influyen en su distribución geográfica mediante análisis cluster (CA) y de componentes principales (PCA). Finalmente, se relacionó el efecto del impacto antropogénico sobre sus áreas de distribución actual.
Resultados clave: El área total que se predice y que es climáticamente adecuada para su presencia es de 67,096 ha. El análisis de las variables ambientales y topográficas mostró que el rango anual de temperatura y la precipitación del mes más seco resultaron ser las más importantes. Se encontró una asociación negativa y significativa con el impacto antropogénico. La Sierra Madre Oriental presenta las condiciones que son el hábitat favorable para la persistencia de A. vejarii.
Conclusiones: La cuantificación de las áreas óptimas que permitan el establecimiento y desarrollo de A. vejarii hará posible diseñar estrategias y prescribir acciones para la conservación y restauración de las poblaciones de esta especie.
Coping Skills and Burnout among Medical Officers in a Malaysian Tertiary Hospital
Authors: Ali Nur Faizah , Nasution Raduan Nor Jannah , Ismail Zaliha , Razali Salmi
Published: March 2020

Burnout among doctors is hazardous, leading to stress which results in poor decision making and exposure to medical errors. This study aims to improve the knowledge gap of the issues of burnout and coping skills among medical officers. This study is a cross-sectional study involving 250 medical officers using universal sampling. Of the total 250 participants, 63 (25.2%) were burnout. The presence of burnout was significantly associated with dysfunctional coping skills (t=-4.96; p <0.001).  Burnout is prevalent among medical officers. It is vital to take actions that can promote good mental health in the form of coping skills and resilience training.
Factors for Effective Repair and Maintenance Services in the Housing Industry: A systematic literature review
Authors: Md Dahlan Farhan , Abdul Tharim Asniza Hamimi , Zainuddin Ashrof , Haffiz Aliasak Mohd Hasrol
Published: March 2020

Most of the residents in high-rise housing do not realise the importance of proper building management until the physical buildings and shared facilities have deteriorated. Accordingly, this paper identified the factors for effective repair and maintenance services in a housing setting by utilising a systematic literature review method. Relevant information was analysed through content analysis techniques across various peer-reviewed journal articles. The results yielded the potential factors for effective repair and maintenance services in high-rise housing. This study thus contributes to the field by deriving valuable reference for property management companies tasked with managing such houses in consideration of the factors necessary for effective repair and maintenance towards building quality and sustainability.
Identity on the Facade of Roi Et Provincial Hall
Authors: Kaewpeela Phatlalitsorn , Raksawin Karuna , Suthasupa Supagtra
Published: March 2020

Roi Et Provincial Hall has been redeveloped according to the policy of the Government Center System Organization, which designates a provincial hall as the center of the provincial government and shall express its local identity. Roi Et Province, thus, has carried out the redevelopment project of the provincial hall of which design has been adhered to a tetrahedron style (a building with four gable ends), a standard building design provided from the central government, and combined with its local identity derived from architectural elements on the facades to present inherited meaning to people's perception. This study aims to find the architectural elements which provide identity on the facade of Roi Et Provincial Hall. The method used includes an investigation of the architectural elements on the facades which affect perception in 3 aspects: mass-form, ornament and texture. The study consists of three steps: 1) an investigation of the old hall's facade, 2) an investigation of local identity buildings' facade, and 3) an interpretation of identity to a design. Finally, a 3D model of Roi Et Provincial Hall is developed.
Improving the Quality of Antenatal Care Using Mobile Health in Madagascar: Five-Year Cross-Sectional Study (Preprint)
Authors: Benski Anne Caroline , Schmidt Nicole C , Viviano Manuela , Stancanelli Giovanna , Soaroby Adelia , Reich Michael R
Published: March 2020

BACKGROUND

Despite many efforts, maternal mortality remains a major burden in most developing countries. Mobile health (mHealth) has the potential to improve access to obstetric care through apps that help patients and providers.

OBJECTIVE

This study aimed to use mHealth to provide antenatal care (ANC) to 1446 pregnant women in a rural area in Madagascar and evaluate the quality of ANC provided by an mHealth system designed to change the behaviors of providers and patients.

METHODS

We included 1446 women who attended ANC visits in rural Madagascar from 2015 to 2019 using an mHealth system called Pregnancy and Newborn Diagnostic Assessment (PANDA). This cross-sectional study used data from different participants, with information collected over several years, to analyze the outputs related to the quality of ANC over time. Specifically, we examined the timing of the first ANC visit, the relationship between the visit duration and the risk factors among pregnant women, and the number of ANC visits per woman.

RESULTS

Following the implementation of the mHealth system in 2015, we observed that women started to come earlier for their first ANC visit; more women attended their first ANC visit in the second trimester of pregnancy in 2019 than in the previous years (P<.001). In 2019, fewer women attended their first ANC visit in the third trimester (57/277, 20.6%) than in 2015 (147/343, 42.9%). There were statistically significant associations between the ANC visit durations and the risk factors, including age (>35 years; 25.0 min, 95% CI 24.0-25.9), educational level (longer visit for women with lower than primary education and for women who attended university and shorter for women with primary school–level education; 40.7 min, 95% CI 30.2-51.3 and 25.3 min, 95% CI 24.4-26.3 vs 23.3 min, 95% CI 22.9-23.8; P=.001), experience of domestic violence during pregnancy, gravidity, parity, infectious diseases (HIV, malaria, and syphilis), and level of anemia. Statistically significant associations were observed for all quality indicator variables. We observed a statistically significant increase in the number of ANC visits per woman over time from 2015 to 2017; the number of ANC visits per woman then became stable after the third year of implementing the PANDA mHealth system.

CONCLUSIONS

This study shows the potential of an mHealth system to improve the quality of ANC, change provider behavior by standardizing ANC visits, and change patient behavior by increasing the willingness to return for subsequent visits and encouraging ANC attendance early in pregnancy. As this is an exploratory study, further studies are necessary to better understand how mHealth can change behavior and identify the conditions required for behavioral changes to persist over time.
Extent of Commitment of Accountants in Lebanon to Implementing the International Accounting Standard 16: Property, Plant and Equipment (An Empirical Study)
Authors: Ayoub Maysa , El-Mousawi Dr. Hasan
Published: March 2020

Tangible fixed assets are fundamental to the organization; thus, the International Accounting Standards Board (IASB) issued International Accounting Standard 16, (IAS 16—Property, Land and Equipment), which includes regulations that organize the recognition, measurement and disclosure of those assets. Later versions of the standard improved and updated the standard. The research aims at studying the extent of commitment of Lebanese accountants to implementing IAS 16. The researchers used a descriptive, analytical approach to tackle their topic. A well-structured five-point Likert style questionnaire was used to collect data. The samples were all members of the Lebanese Association of Certified Public Accountants (LACPA). The results of the study showed a difference of statistical significance within the opinions of the study samples about the extent of commitment of LACPA members to applying IAS 16. The research reached that accountants in Lebanon apply only some items of IAS 16, which the research tool specified. The researchers had some recommendations based on the findings of the research.
FORMULATION AND OPTIMIZATION OF CURCUMIN SOLID DISPERSION PELLETS FOR IMPROVED SOLUBILITY
Authors: DESHKAR SANJEEVANI , SATPUTE ARUN
Published: March 2020

Objective: The present study was aimed at designing of solid dispersion based pellets of curcumin (Cu) for improving its solubility.

Methods: Solid dispersion (SD) of Cu was prepared by the melt method using Poloxamer 407 (Pol 407) at a different weight ratio of Cu-Pol 407 (1:2, 1:3, 1:5, 1:7, 1:10). The solid dispersion was characterised by FTIR, SEM, DSC, XRD and evaluated for saturation solubility in water, drug content and in vitro dissolution. The pellets of Cu solid dispersion were prepared by extrusion spheronization technique and optimization was performed by 32full factorial design. The pellets were evaluated for size distribution, flow properties, hardness, disintegration and in vitro drug dissolution.

Results: From the phase solubility analysis, Pol 407 was selected as a Solid dispersion carrier. The formation of Cu-SD by melt method using Pol 407, was confirmed from FTIR and DSC studies. XRD studies indicated a change of Cu from crystalline to amorphous form. There was a significant increase of Cu when formulated as SD compared to plain Cu. The optimization of extrusion spheronization process revealed the significant effect of Cu-Pol 407 ratio (p<0.0001) on in vitro dissolution of pellets. Higher Cu dissolution was obtained with Cu-SD pellets compared to plain Cu pellets.

Conclusion: The present study demonstrated the potential of Cu-SD pellets in improving the solubility of poorly soluble Cu.
OPTIMIZATION AND CHARACTERIZATION OF CHITOSAN-BASED NANOPARTICLES CONTAINING METHYLPREDNISOLONE USING BOX-BEHNKEN DESIGN FOR THE TREATMENT OF CROHN’S DISEASE
Authors: SHARMA GANESH N. , KUMAR C. H. PRAVEEN , SHRIVASTAVA BIRENDRA , B. KUMAR
Published: March 2020

Objective: The present research was designed to produce methylprednisolone containing chitosan-based nanoparticles using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) for optimization.

Methods: Nanostructures were prepared using the ionic gelation method with screened process parameters. According to the design, methylprednisolone chitosan-based nanoparticles (MCSNPs) were optimized using factors like methylprednisolone concentration, stirring speed and temperature whereas particle size, zeta potential and % encapsulation efficiency as responses. From the observed values of responses with confirmation location and desirability, the predicted values were very close to the observed values.

Results: Observed values for the optimized formulation have a particle size of 243±2.33 nm with an encapsulation efficiency of 79.3±7.2%. Morphology of the particles using scanning electron microscopy reveals nearly spherical shaped particles. Methylprednisolone was released in vitro in a sustained manner for about 24 h in simulated colonic fluid pH 7, pH 7.8 (Fasted state) and phosphate buffer pH 7.4, when compared to simulated colonic fluid at pH 6 (Fed state). Optimized MCSNPs followed Korsmeyer peppas kinetics with drug release mechanism as anomalous transport.

Conclusion: Application of Box-Behnken design and Response Surface Methodology using Design Expert software was successfully used in the optimization of methylprednisolone loaded chitosan-based nanoparticles with high encapsulation efficiency.
EQUIVALENCE STUDY OF IMMEDIATE RELEASE TABLETS OF BETA BLOCKER DRUG
Authors: GABER DALIA , ABDOUN SIHAM , MASWADEH HAMZAH , ALNASSR EBTIHAL , SALAMAH MARAM AL
Published: March 2020

Objective: The therapeutic equivalence of generic brands is a great challenge for manufacturers. This study aimed to evaluate the bioequivalence of four different generic brands of atenolol tablets under biowaiver conditions.

Methods: Physiochemical properties of the tablet products namely uniformity of weight, hardness, disintegration, and drug content were assessed. The dissolution profiles of atenolol tablets were conducted in pH 1.2, 4.5, 6.8 and 7.6 buffers using USP dissolution apparatus II. Similarity and difference factors were calculated. Finally, four kinetic models have been offered to describe the release characteristics of atenolol under experiment conditions.

Results: All tablets showed accepted physiochemical characters. Dissolution profiles revealed that G2 showed the highest similarity to innovator (f2 91.86) in pH 7.6. Dissolution kinetics of G2 at the same pH could be best described as Higuchi model of release. 

Conclusion: The study showed that excipients and manufacturing practices play an important role in marketing biowaiver generic products meet the international regulatory bodies criteria.
SOMATOSTATIN ANALOGUES FOR THE TREATMENT OF NEUROENDOCRINE TUMOURS. DOSAGE FORMS AND ROUTES OF ADMINISTRATION (REVIEW)
Authors: SHPRAKH ZOYA
Published: March 2020

This review summarises information on drug products Somatostatin Analogues (SSAs), which are included in the algorithm of Neuroendocrine Tumors (NET) treatment. SSAs are the current standard for safe and effective management of NET symptoms and control of tumours growth and are administered in a range of dosage forms for parenteral administration, such as intramuscular, subcutaneous and implant. A search criterion was the therapy of NET with medicines from a group of SSAs. Literature survey has been done in a range of years 1990-2018 to make the review updated and comprehensive and to show the development of SSAs new pharmaceutical dosage forms to improve patient quality of life and side effects decrease. The sources were world-recognized journals. Keywords used as filters were NET, SSAs, octreotide, lanreotide, pasireotide, Somatostatin Receptors (SSTR), dosage form. The current review is created with an intended to focus on the advantage of SSAs modern dosage forms. Literature survey revealed that many studies were carried out to SSAs encapsulation into microspheres that changes the drug bioavailability and allows reducing the number of administration. Also, SSAs delivery systems in particular devices such as auto-injector have been created to control the continuous concentration of the drug and to provide safety guarantee. Besides, studies have been carried out to prepare SSAs formulations for oral administration to improve the quality of life of the NET patients. In this review, SSAs pharmaceutical dosage forms with improved pharmacokinetic and therapeutic characteristics and routes of administration are analyzed.
PREPARATION AND CHARACTERIZATION OF ANCHOVY (STOLEPHORUS SP) PROTEIN CONCENTRATE NANOPARTICLE USING IONIC GELATION METHOD
Authors: SAPIUN ZULFIAYU , IMRAN ARLAN K. , WICITA PRISCA SAFRIANI , KAMBA VYANI , SLAMET NANGSIH SULASTRI
Published: March 2020

Objective: Nanoparticle preparation can increase the bioavailability of anchovy protein. This study aims to optimize and characterize anchovy protein concentrate nanoparticle based on volume comparison of chitosan-TPP (Tripolyphosphate) matrix in forming the size of anchovy protein concentrate nanoparticle with ionic gelation method.

Methods: Fresh anchovy was extracted by an acid-base method using solvents of NaOH and HCl to get protein concentrate. After that, it was conducted by formulating anchovy protein concentrate into a mixture of chitosan-TPP matrix with volume ratio which was divided into 5 series of variations, namely F1 without matrix, F2 1:1, F3 1:3, F4 1:5 and F5 1:7 ratio of chitosan to TPP, then formed matrix was determined the value of the encapsulation efficiency and characterized using a particle size analysis tool.

Results: The results showed that the optimum volume comparison of the chitosan-TPP matrix in forming nanoparticle of anchovy protein concentrate was ratio 1:7 because this has a matrix encapsulation efficiency value of 99.11%, a small particle concentrate size of 687.26 nm, a good polydispersity index value of 0.406 and a value of zeta potential of+12.9 mV.

Conclusion: The optimum formula of the chitosan-TPP matrix volume ratio in forming anchovy protein concentrate nanoparticle is F5 with the ratio of chitosan-TPP matrix mixture 1:7.
PREPARATION OF ORAL CURCUMIN DELIVERY FROM 3D-NANO-CELLULOSE NETWORKS MATERIAL PRODUCED BY ACETOBACTER XYLINUM USING OPTIMIZATION TECHNIQUE
Authors: NGUYEN THANH XUAN , PHAM HUONG LAN THI , NGO THUONG THI , ONG PHONG XUAN
Published: March 2020

Objective: To prepare oral curcumin delivery and optimize curcumin loading of 3D-nano-cellulose networks material (3DCM) by looking into the impact of process variables on the response utilizing response surface methodology (RSM) and Box-Behnken design.

Methods: Optimization of curcumin loading of 3DCM was conducted using RSM and Box-Behnken model. Impact of four independent variables, including, the concentration of curcumin (X1), temperature (X2), shaking speed (X3), and time of loading (X4), was studied on one dependent response, that is, an amount of loaded curcumin (Y). Characterization of optimized 3DCM including curcumin was examined by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) analysis .

Results: R2 value for Y was approximately 0.94. X1 possessed the biggest positive impact compared to X2, X3 and X4. Optimized conditions for curcumin loading of 3DCM were X1 at 3 mg/ml, X2 at 40 °C, X3 at 120 rpm and X4 at 120 min. SEM photograph of 3DCM surfaces were found including fibers creating a 3D network structure. FTIR spectra studies depicted that there was no interaction between curcumin and 3DCM.

Conclusion: The data obtained in this study thus suggest that curcumin loaded 3DCM was successfully fabricated to give a potential oral delivery system of curcumin.
ASCORBIС ACID DEGRADATION IN N, N-DIMETHYLFORMAMIDE SOLUTIONS
Authors: SYROESHKIN A. V. , PLETENEVA T. V. , USPENSKAYA E. V. , SAYDINOV I. I. , LEVITSKAYA O. V. , ELIZAROVA T. E. , TRIBOT-LASPIERE M. A. , ODNOVOROV A. I.
Published: March 2020

Objective: Investigate the mechanisms of L-ascorbic acid transforтmation and formation of coloured enamines in N, N-dimethyl-formamide solutions.

Methods: An automatic polarimeter Atago POL-1/2 was used for polarimetric investigation. Electronic spectra were recorded by UV-spectrometer Cary 60 (Agilent). The statistical analysis was carried out using the OriginPro 9.1 packages.

Results: The Biot’s law violation was found in below 0.1% solutions of L-ascorbic acid (AA) in N, N-dimethylformamide (DMF). During the day, the specific rotation   of 1% AA solution varied from+37 to-1.0. Gradually, the solution acquired the red colour, and its intensity depended on the AA concentration. Spectrophotometrically, it was shown that after 15 min AA was absent in the n·10-3% solutions. The decomposition followed the first-order kinetics (k1=1.83·10-2с-1). At the same time, new absorption bands appeared at 273, 390, 533 nm. Model solutions containing dimethylamine (DMA) had a similar spectrum, and the intensity of the absorption bands increased in proportion to the concentration of DMA.

Conclusion: The results show that the first step in the decomposition of ascorbic acid AA in DMF follows first-order kinetics. Numerous decomposition products are optically active compounds and reverse the sign of the optical rotation of the solution. The water resulting from the decomposition of AA is involved in the hydrolysis of the solvent. The hydrolysis product, the secondary amine DMA, interacts with the carbonyl groups of the AA decomposition products to form coloured enamines. Magnesium (II) accelerates the formation of coloured products.
ZOLMITRIPTAN BRAIN TARGETING VIA INTRANASAL ROUTE USING SOLID LIPID NANOPARTICLES FOR MIGRAINE THERAPY: FORMULATION, CHARACTERIZATION, IN-VITRO AND IN-VIVO ASSESSMENT
Authors: MOSTAFA DALIA A. ELATY , KHALIFA MAHA K. A. , GAD SAMEH. S.
Published: March 2020

Objective: Zolmitriptan, a class of antidepressant drugs with poor bioavailability due to its first-pass metabolism. The aim of this study was to improve systemic bioavailability and explore the brain targeting impact of nasal Zolmitriptan (Zol) solid lipid nanoparticles (SLNs) gel for migraine treatment. 

Methods: Stearic acid and cholesterol used as solid lipid and lecithin as a surfactant, emulsion solvent evaporation technique was used to produce Zolmitriptan SLNs. (Zol) SLNs were characterized for particle size, percent entrapment efficiency and in vitro drug release. Formula S6 showed greater percent entrapment efficiency (PEE), adequate particle size and sustained drug release behavior. Formula S6 was integrated into HPMC gel (3%) to prepare nasal gel. Zol SLN nasal gel was subjected to histopathological study to ensure brain targeting. 

Results: It was observed that all prepared Zol SLNs were in the nano-sized range with a polydispersity index of<0.5. In the cholesterol/lecithin combination, higher PEE%, better stability, and less agglomeration inclination were discovered. Results of the release profiles showed that developed Zol-SLNs were able to release Zolmitriptan in a sustained manner. Histopathological study of the brain tissues showed that Zolmitriptan SLN nasal gel can reach brain cells and localized for 24 h although the hydrophobicity of the target drug.

Conclusion: Intranasal administration of Solid lipid nanostructure of Zolmitriptan through the olfactory pathway in which it travels from the nasal cavity to brain tissue achieved drug targeting potential of about 90% compared with conventional Zolmitriptan tablets. The small particle size helped them to squeeze themselves through the small opening in the olfactory neurons to the brain via different endo-cystic pathways of neuronal cells in nasal tissue membranes.
Os Crimes de Verdade: As Memórias de Camilo
Authors: Alves Monteiro de Castro Andreia
Published: March 2020

O presente artigo observa de que modo, usando o conhecimento adquirido em obras sobre criminosos verídicos, como Maria, não me mates que sou tua mãe (1848), em Memórias do Cárcere (1862), Camilo Castelo Branco comprova que boa parte da violência é cometida justamente por aqueles que deveriam proteger os cidadãos e que a cadeia era um mundo essencialmente habitado por pobres. A partir de um relato minucioso e, por vezes, lírico, Camilo comenta como era o cotidiano no interior daquele que era o maior instrumento de repressão oitocentista. Um desses prisioneiros, José do Telhado, graças a pena camiliana, ganha fama e notoriedade despertando o interesse de muitos leitores e de outros autores.
Las tecnologías de la información y la comunicación como medio educativo para la adquisición de competencias profesionales del alumnado de educación superior
Authors: Herrero Rafaela , Marín Verónica , González Ignacio
Published: March 2020

El artículo que se presenta es una investigación educativa sobre la adquisición decompetencias profesionales a través de estrategias metodológicas basadas en tecnologíasde la información y la comunicación (TIC) en el marco del Espacio Europeo deEducación Superior (EEES). El escenario de estudio elegido fue la experiencia piloto implantada en el Centro de Magisterio "Sagrado Corazón" con el alumnado universitariode la especialidad de Educación Primaria.El propósito de esta investigación ha sido dar respuesta a los siguientes interrogantes: ¿Las metodologías basadas en TIC mejoran el aprendizaje y favorecen la adquisición de competencias profesionales del alumnado?; ¿Qué mejoras representan en el aprendizaje del alumnado, la incorporación de sistemas metodológicos basados en TIC, para la adquisición de competencias profesionales?
Lectura de artista. El caso de la Facultad de Artes de la Universidad Nacional de Córdoba
Authors: Borioli Gloria , Scarafía Silvia , Fantino Ivana , Peralta Bethania , Utrera Marcelo
Published: March 2020

En un texto que cruza el ensayo y el informe de investigación y abrevando en dos fuentes -el proyecto Jóvenes y discursos. Los sujetos dicen de sí, dirigido por la Mgter. Gloria Borioli (Universidad Nacional de Córdoba) y el Programa de Apoyo yMejora del Grado en la Facultad de Artes de la Universidad Nacional de Córdoba-, el artículo enlaza voces de estudiantes y profesores de Cine y T.V., Artes Visuales, Teatro y Música, para advertir en la práctica lectora pistas que permitan revisar las propuestas didácticas. Así, las conclusiones provisionales de un sondeo cualicuantitativo que retoma investigaciones académicas (Bidiña & Zerillo, 2013; Brito, 2010; Colomer, 1997; y otros) dialogan con insumos procedentes de la novela (Baricco, 2005), del psicoanálisis (Cantú, 2004) y de la sociología de la lectura (Chartier, 2001; Manguel, 2005) para pensar cuál es el lugar de las prácticas de lectura en la formación de grado.
The Comparative Study of Textile and Cement Sector of Pakistan
Authors: Mansoor Hadia
Published: March 2020

The purpose of this study is to find the internal and external determinants of profitability of textile and cement sector of Pakistan. Secondary data is collected from “Financial Statement Analysis of companies (non-financial) listed at Karachi Stock Exchange” for the period of 2005-2010 by using the random and convenient sampling technique. Dependent variables consist of ROA and ROE and independent variables are liquidity, leverage, growth, capital intensity, size and market share. Out of the six variables, first four represents the internal factors and remaining two are external factors. Panel data analysis is applied to find the relationship among dependent and independent variables. The results of this study indicate that the liquidity and leverage impact significantly in the textile sector but growth, capital intensity, size and market share have no relevance with the profitability of this sector. In case of cement sector, liquidity, leverage and growth shows considerable effect while other factors are insignificant. This study is useful for the management of these sectors while carrying out any decision regarding internal and external variables.
STUDENTS ENTREPRENEURSHIP INTENTION IN METROPOLITAN AND INDONESIA FREE TRADE ZONE: IS IT DIFFERENT?
Authors: Prakoso Albrian Fiky , Soesatyo Yoyok , Kurniawan Riza Yonisa
Published: March 2020

This study aims to determine the Entrepreneurship Intention of students in Universitas Negeri Surabaya (Unesa) which is a metropolitan area and Riau Islands University (Unrika) in Indonesia Free Trade Zone. To distinguish Entrepreneurship Intention from students in this study using Theory of Planned Behavior (TPB). This type of research is quantitative exploratory research. Data analysis using Structural Equation Modeling (SEM) with the WarpPLS approach. Respondents in this study are Unesa and Unrika students, 6th-semester Economics or had taken entrepreneurship courses with a total of 142 students. There are similar intentions of Unrika entrepreneurship with Unesa. In Unrika, they were in the free trade zone area so they were more consumptive towards electronics because of their low price and reluctant to be entrepreneurs. In the free trade zone, if we want to sell an item outside the island, it will be charged by the gonverment, and the price will be same like the price from the outside of free trade zone. Moreover, most of their parents are workers or civil servants and not entrepreneurs. The cause of Unesa students is reluctant to become entrepreneurs because most of them want to become civil servants based on the influence of the family environment which on average comes from the village and works as a civil servant. For Unrika, most of them are college workers, so their mindset before and when they are studying is as workers.
The Influencing Factors on Taxpayer Compliance: A Conceptual Approach
Authors: Aswar Khoirul
Published: March 2020

Starting from the assumption that the problem of taxpayer compliance is important issues throughout the world, both in developed countries or in developing countries because if the taxpayer does not comply, it will cause the desire to do so acts of avoidance, evasion and tax neglect. this research seeks to find out to what extent taxpayers registered with SAMSAT Bekasi City fulfill Motorized vehicle tax liability. Drawing from institutional theory, this study has six objectives: (i) to find out the application of understanding of regulations taxation of taxpayer compliance, (ii) to determine the application of sanctions tax on taxpayer compliance, (iii) to determine the application of the tax rate to taxpayer compliance, (iv) to determine the effect of the application of preferences risks to taxpayer compliance. Therefore, this research contributes to the development of science knowledge and is expected to apply the theory that has been obtained specifically regarding the influence of understanding of tax regulations, tax sanctions and the tax rate for taxpayer compliance, which is moderated by risk preferences.
Affecting Factors on Accountability of Village Fund Allocation Management in Bogor District
Authors: Rahmatulloh Fajar
Published: March 2020

This research aimed to find out factors which affected accountability of village fund allocation management in Bogor district. Population in this research was village heads and village secretaries in Bogor district. The hypotheses were tested using data surveys from 77 respondents. The analysis technique used multiple linear regression. The findings from this research indicated that the competence of village officials affected the accountability of village fund management. Whereas, society participation and supervisors had no effect on accountability in the management of village fund allocations. This research contributed to the use of village fund allocations in the Indonesian village government. The further research should the interview method to dig deeper into the management of village funds. In addition, further research is expected to expand research to not be only focused on villages in Bogor District.
Modeling Cross Category Purchase Decision Making with Consumers’ Mental Budgeting Control Habit
Authors: Yang Zhiguo
Published: March 2020

Cross-category decision making is an ongoing research in decision science. Cross-category modeling is a powerful tool for big data and business analytics. Cross-category decision making involves evaluating multiple categories for complementary/substitutional utilities. This paper examines consumers’ mental budgeting control habit for its impact on cross purchase decisions. This factor has not been examined in existing cross modeling literature. This paper fits a base cross category model and a budgeting control habit cross model using a consumer grocery shopping dataset. The results show that by incorporating this variable in the cross model, model fit score and prediction accuracy are significantly improved. The budgeting control habit factor has significant moderating effects on price effects and cross price effects. In addition to providing the modeling technique, this paper also finds that consumers classify basket items into root and add-on categories. The common sense that price drop boosts sales is only true for the root category items. Price drop of add-on items may trigger consumers reconfiguring their basket items but not necessarily increase sales of the add-on items themselves.
Reflexiones sobre la vocación profesional para avanzar hacia la cobertura nacional de una educación permanente
Authors: Candia García Filiberto
Published: March 2020

Actualmente, debido a la brecha curricular que existe entre la educación básica y la superior, el rol que desempeña la educación media superior (EMS) es de vínculo entre estas dos. En este trabajo se considera que, al no romper esta condición de falta de metas compartidas entre los currículos de la educación básica y la superior y seguir trabajando de forma aislada, el Estado mexicano queda sometido a un reduccionismo educativo que impacta de manera negativa en el desarrollo sostenible del pueblo. Por ello, el objetivo es generar condiciones de equidad educativa entre organismos públicos y privados que imparten la EMS de manera que permitan fomentar e integrar la vocación de los individuos en su desarrollo profesional o laboral. Este documento de reflexión gira en torno a la oportunidad que tiene la EMS para ser un medio que les permita a los mexicanos convertirse en personas soberanas y autónomas a través del seguimiento y atención de su vocación profesional o laboral por parte de los sistemas educativos. Solo así será posible generar una alta satisfacción profesional y laboral que permita a la población económicamente activa ser consciente de su entorno y de su ecosistema y que motive a cada individuo a evolucionar como una persona que vive en armonía con sus semejantes y procurar el bien común entre entidades productivas y sociales. Entre las conclusiones se encuentra que la concurrencia de metas en el currículo de la educación básica, la EMS y la superior, motivada por la orientación vocacional, genera acciones concretas a favor de la cobertura formativa por medio de la educación permanente, la cual permitirá recobrar las condiciones y características del bien común, como la dignidad de los docentes y la atención individualizada a los estudiantes.
Covid 19 evidencia
Authors: Herrera Diego , Gaus David
Published: March 2020

Ante la gran expectativa mundial por la nueva epidemia de coronavirus, la revista Practica Familiar Rural pone a disposición de estudiantes y profesionales de la salud, y de la sociedad en general, una lectura crítica de la evidencia actualizada sobre la nueva epidemia, realizada por nuestros compañeros Diego Herrera y David Gaus.
Como enfrentar el COVID 19
Authors: Herrera Diego
Published: March 2020

A medida que el brote de la enfermedad por coronavirus 2019 (COVID-19) avanza a nivel mundial, existe presión sobre los investigadores, para que muestren el valor de la historia para promover el cambio en las políticas en salud, en el fondo existe una acusación más o menos explícita, de ¿por qué no aprendimos de las epidemias pasadas?