bluuebunny/crossref_metadata_2025 huggingface dataset:
Disease relapse in relation to lymph node sampling in lung carcinoid patients
Authors: Moonen Laura , Derks Jules L , Hillen Lisa M , van Suylen Robert Jan , den Bakker Michael A , Thüsen Jan H von der , Damhuis Ronald A , Buikhuisen Wieneke A , van den Broek Esther C , Maessen Jos , Maat Alexander P W M , van Schil Paul , Speel Ernst J M , Dingemans A-M C
Published: June 2024

The predictive value of the extent of peri-operative lymph node (LN) sampling in relation to disease relapse in patients with pulmonary carcinoid (PC) is unknown. Furthermore, post-surgery follow-up recommendations rely on institutional retrospective studies with short follow-ups. We aimed to address these shortcomings by examining the relation between LN sampling and relapse in a population-based cohort with long-term follow-up. By combining the Dutch nationwide pathology and cancer registries, all patients with surgically resected PC (2003–2012) were included in this analysis (last update 2020). The extent of surgical LN dissection was scored for the number of LN samples, location (hilar/mediastinal), and completeness of resection according to European Society of Thoracic Surgeons (ESTS) guidelines. Relapse-free interval (RFI) was evaluated using Kaplan Meier and multivariate regression analysis. 662 patients were included. The median follow-up was 87.5 months. Relapse occurred in 10% of patients, mostly liver (51.8%) and locoregional sites (45%). The median RFI was 48.1 months (95% CI 36.8–59.4). Poor prognostic factors were atypical carcinoid, pN1/2, and R1/R2 resection. In 546 patients LN dissection data could be retrieved; at least one N2 LN was examined in 44% and completeness according to ESTS in merely 7%. In 477 cN0 patients, 5.9% had pN1 and 2.5% had pN2 disease. In conclusion, relapse occurred in 10% of PC patients with a median RFI of 48.1 months thereby underscoring the necessity of long-term follow-up. Extended mediastinal LN sampling was rarely performed but systematic nodal evaluation is recommended as it provides prognostic information on distant relapse.
Hamster spermatozoa incorporate hypotaurine via TauT for self-protection
Authors: Takei Gen L , Horibata Yasuhiro , Toyama Fubito , Hayashi Keitaro , Morita Asuka , Ouchi Motoshi , Fujita Tomoe
Published: June 2024

In brief

Mammalian spermatozoa actively generate reactive oxygen species (ROS) during capacitation, a maturational process necessary for fertilization in vivo. This study shows that hypotaurine, a precursor of taurine present in the oviduct, is incorporated and concentrated in hamster sperm cells via the taurine transporter, TauT, for cytoprotection against self-produced ROS.

To achieve fertilization competence, mammalian spermatozoa undergo capacitation, during which they actively generate reactive oxygen species (ROS). Therefore, mammalian spermatozoa must protect themselves from these self-generated ROS. The mammalian oviductal fluid is rich in hypotaurine, a taurine precursor, which reportedly protects mammalian spermatozoa, including those of hamsters, from ROS; however, its precise mechanism remains unknown. This study aimed to elucidate the mechanism underlying hypotaurine-mediated protection of spermatozoa from ROS using hamsters, particularly focusing on the taurine/hypotaurine transporter TauT. The effect of hypotaurine on sperm motility and ROS levels was tested using sperm motility analysis and the CellROX dye and luminol assays. RNA sequencing analysis was performed to verify TauT expression. We found that hypotaurine was necessary for maintaining sperm motility and hyperactivated motility. Hypotaurine did not scavenge extracellular ROS but lowered intracellular ROS levels and was incorporated and concentrated in hamster spermatozoa. TauT was detected at both mRNA and protein levels. β-Alanine blocked hypotaurine transport, increased intracellular ROS levels, and inhibited hyperactivation. Elimination of Na+ or Cl− ions inhibited hypotaurine transport and increased intracellular ROS levels. Thus, these results indicated that hamster spermatozoa incorporated and concentrated hypotaurine in sperm cells via TauT to protect themselves from self-generated ROS.
Resistencia y sensibilidad de Fasciola hepatica frente a cuatroprincipios activos antihelmínticos en cuyes (Cavia porcellus),Cajamarca, Perú
Authors: Ravines José , Torrel Severino , Florián Alcántara Amarante , Vargas-Rocha Luis , Manrique Judit Estela , Rojas-Moncada Juan
Published: June 2024

The study aimed to evaluate the efficacy of four anthelmintics in the control of Fasciola hepatica at the Estación Experimental del Instituto Nacional de Innovación Agraria (INIA), Baños del Inca, Cajamarca, Perú. Forty guinea pigs from 5 to 12 months of age of the Inka line, naturally infected with F. hepatica (≥1 HPG), not dewormed in the last 4 months, under the same management and feeding system were used. The animals were distributed into four groups (n=10): triclabendazole (25 mg/kg) and closantel (20 mg/kg) orally, clorsulon + ivermectin (15 mg/kg based on clorsulon) and nitroxinil (50 mg/kg) subcutaneously. The parasite load was determined on days 0 and 30 post-dosing. The Egg Count Reduction Test determined an efficacy of 0% for triclabendazole and 100% for closantel, clorsulon + ivermectin, and nitroxinil. It is concluded that F. hepatica is resistant to triclabendazole and sensitive to closantel, clorsulón + ivermectin and nitroxinil in guinea pigs from INIA-Cajamarca.
“THE MYSTERIOUS AUTHOR” FROM SPASSKY: A LETTER FROM I. S. TURGENEV TO P. V. ANNENKOV DATED OCTOBER 14, 1853
Authors: Gennady Karpenko
Published: June 2024

In the article, the letter of I. S. Turgenev to P. V. Annenkov dated October 14, 1853, which structurally comprises a “physiological essay” about a “little man” and an Easter poem allegedly written by this “little man,” and in fact — by a “mysterious author,” is analyzed. The letter is considered as a letter-work that has already overcome the narrow framework of the epistolary genre during the writer’s life and has become a discussed text. In Turgenev studies, however, the question of the biographical author of the Easter poem remains the main issue in examining the letter: today, in the reader’s space, the poem de facto functions as a work of both Turgenev and Lermontov. The “prosaic” part of the letter about the painter-poet is considered by researchers to be preparatory material for a subsequent work. Meanwhile, the letter is a “cryptographic text,” and as a whole conceals a hidden “Pushkin code,” which is “read” thanks to numerous hints contained both in the letter itself, in its “prosaic” and poetic parts, and in the friendly correspondence between Turgenev and Annenkov. A comparative analysis of the two texts of the Easter poem prepared by the Turgenev academic group, one of which is in a letter dated October 14, 1853, and the other, in the Dubia section, revealed numerous discrepancies in these texts, as well as their significant deviation from the original text published in the Literary Gazette in 1840. In academic texts, all sacred words — the Glory of God, the Son of God — are graphically eliminated. Such eradication of religious and aesthetic feeling, “concealed” in the graphic “decapitation” of the names of Christ, again actualizes the issue of the need to publish the creative heritage of Russian classics in an authentic form.
An extended Suja distribution with statistical properties and applications
Authors: Shanker Rama , Das Ronodeep , Shukla Kamlesh Kumar
Published: June 2024

An extended Suja distribution, of which one parameter Suja distribution is a particular case, has been proposed. Important statistical properties of the proposed distribution based on moments, skewness, kurtosis, index of dispersion, hazard rate function, mean residual life function, stochastic ordering, mean deviations, Renyi entropy measures, and stress-strength reliability have been derived and studied. The method of moments and the method of maximum likelihood for estimating parameters have been discussed. A simulation study has been presented to know the performance of maximum likelihood estimates. Applications and goodness of fit of the proposed distribution with two real datasets have been presented.
Closer to Home: A Quality Improvement Initiative to Optimize Satellite Site Bed Capacity
Authors: Herrmann Lisa E. , Hubbell Brittany , Taylor Abigail , Duma Elena , Warniment Amanda , Smith Lauren , Mailloux Eric , Szczepanski Karen , Schmidlin Emily , Mitchell Michelle , Kientz Liesl , Albrecht Jennifer , White Christine M. , Statile Angela M.
Published: June 2024

BACKGROUND

The coronavirus disease 2019 pandemic resulted in the underutilization of inpatient beds at our satellite location. A lack of clarity and standardized admission criteria for the satellite led to frequent transfers to the main campus, resulting in patients traveling larger distances to receive inpatient care. We sought to optimize inpatient resource use at the satellite campus and keep patients “closer to home” by admitting eligible patients to that inpatient unit (LA4). Our aim was to increase bed capacity use at the satellite from 45% to 70% within 10 months. Our process measure was to increase the proportion of patients needing hospitalization who presented to the satellite emergency department (ED) and were then admitted to LA4 from 76% to 85%.

METHODS

A multidisciplinary team used quality improvement methods to optimize bed capacity use. Interventions included (1) the revision and dissemination of satellite admission guidelines, (2) steps to create shared understanding of appropriate satellite admissions between ED and inpatient providers, (3) directed provider feedback on preventable main campus admissions, and (4) consistent patient and family messaging about the potential for transfer. Data were collected via chart review. Annotated run charts were used to assess the impact of interventions over time.

RESULTS

Average LA4 bed capacity use increased from 45% to 69%, which was sustained for 1 year. The average percentage of patients admitted from the satellite ED to LA4 increased from 76% to 84%.

CONCLUSIONS

We improved bed capacity use at our satellite campus through transparent admission criteria and shared mental models of patient care needs between ED and inpatient providers.
Genomic insights into NDM-1-producing Pseudomonas aeruginosa: Current status in a Bulgarian tertiary hospital and on the Balkans
Authors: Strateva Tanya , Keuleyan Emma , Peykov Slavil
Published: June 2024

The present study aimed to explore the genomic characteristics of eight New Delhi metallo-β-lactamase-1 (NDM-1)-producing carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates from a Bulgarian tertiary hospital (2021–2023) in comparison to blaNDM-1-positive strains originating from the Balkans. Antimicrobial susceptibility testing, phenotypic assays for carbapenemase activity, PCR screening, whole-genome sequencing (WGS), and phylogenomic analysis were performed. Seven of the CRPA isolates investigated (Minimum inhibitory concentration values of imipenem and meropenem >32 mg L−1) were also resistant to piperacillin-tazobactam, ceftazidime, ceftazidime-avibactam, cefepime, ceftolozane-tazobactam, amikacin, tobramycin, ciprofloxacin, and levofloxacin, but were susceptible to colistin (0.5–2 mg L−1) and cefiderocol (0.25–1 mg L−1). The P. aeruginosa Pae57 isolate (designated Pae57) remained susceptible to aminoglycosides as well. WGS uncovered the co-existence of blaNDM-1 and blaGES-1. The isolates belonged to the ST654 high-risk clone, except for Pae57 (ST611). Alignment against reference sequences revealed the presence of a Tn21 transposon harboring bleMBL–blaNDM-1–ISAba125. It was similar to that found in the P. aeruginosa ST654 NDM1_1 strain (GCA_020404785.1) from Serbia. Phylogenomic analysis of our isolates indicated that seven of them (ST654) differed from each other in no more than 44 single-nucleotide polymorphisms (SNPs). Pae57 (ST611) was strikingly different (>21,700 SNPs) compared to all Balkan strains. In conclusion, to our knowledge this is the first report of blaNDM-1-positive P. aeruginosa ST611 isolation, which indicates the transmission dynamics of this determinant between high-risk and potentially high-risk P. aeruginosa clones. Obtained results unveil the dissemination of clonally related NDM-1-producing P. aeruginosa strains in the monitored hospital for approximately a 2-year period.
An Archaic Compound Suffix in Old Uyghur: +DXrtI
Authors: Azılı Kenan
Published: June 2024

As many world languages, Turkic also has simple suffixes in terms of structure, as well as complex suffixes with controversial origins. Although some of these suffixes have been systematized and bound to certain rules, the emergence of some suffixes still remains a mystery. Old Uyghur, which is one of the historical periods of the Turkic language, has such an undeciphered suffix. The compound suffix of +DXrtI has been evaluated by some researchers to date; however, no definite conclusion has been reached regarding its origin and function. For this purpose, various structures in Altaic languages will be examined and a connection will be made between this suffix and the ‘extraordinary’ examples seen in Old Uyghur.
Utilizing melanoidin consuming microalgae for electricity generation and wastewater treatment via photosynthetic microbial fuel cell
Authors: Chaijak Pimprapa , Changkit Nopparit , Kongthong Alisa
Published: June 2024

Aim of the study

In our investigation, the freshwater microalgae Chlorella sp. BF01 to degrade the melanoidin in the palm oil mill effluent and generate electricity in the photosynthetic microbial fuel cell (PMFC).

Material and methods

The freshwater microalgae Chlorella sp. were used in a PMFC consortium for the degradation of melanoidin and electricity generation. The removal (%), electrochemical properties, and biomass recovery were monitored without adding exogenous medium.

Results and conclusions

In this study, lipid-producing microalgae were employed as whole-cell biocatalysts in a PMFC using palm oil mill effluent as a substrate. The maximal melanoidin removal of 79.54±0.45% was gained. The maximum power density reached was 3.98±0.10 W/m3. The research presents findings that pave the way for the practical implementation of this innovative approach on an industrial scale.
CLUE: A CLUSTERING-BASED TEST REDUCTION APPROACH FOR SOFTWARE PRODUCT LINES
Authors: Vo Hieu Dinh , Nguyen Thu-Trang
Published: June 2024

Nowadays, organizations have increasingly turned to software product lines (SPLs)/configurable systems to meet diverse user needs and market demands. SPLs offer configurability and scalability but pose a formidable challenge in testing. Assuring the quality of variants across numerous configurations demands innovative testing strategies that balance effectiveness and efficiency. To improve testing productivity, test reduction techniques have been widely employed in non-configurable code. However, test reduction for SPL systems remains mostly unexplored. This paper introduces CLUE, a novel test reduction approach to enhance testing productivity in SPLs. Our idea is that to effectively and efficiently reveal failures, tests should be distinctive and cover diverse behaviors of the system. Meanwhile, similar tests covering the same/similar behaviors of an SPL system do not need to be redundantly executed multiple times. CLUE clusters the system’s tests into distinctive groups containing similar tests. Within each cluster, tests are prioritized based on the number of feature interactions, a common root cause of defects in SPLs. CLUE continually selects and executes the top-prioritized test in each cluster until a bug is revealed or the allocated effort budget is exhausted. To evaluate CLUE, we conducted several experiments on a dataset of six widely-used SPL systems. The results show that CLUE enables developers to detect defects earlier, requiring up to 88% less effort than existing approaches. Additionally, using only 50% of the original test suites, CLUE can identify most of the bugs in the buggy SPL systems while maintaining fault localization performance.
Spleen Toxicity Assessment of Propanil Exposure in Swiss Albino Mice
Authors: Cakici Ozlem , Akat Esra
Published: June 2024

Pesticides or their metabolites may have the capacity to disturb and hinder the functions of some essential organs including spleen. This study examined side effects of propanil on the spleen of mice. Experimental groups were exposed to propanil through oral administration for 30 consecutive days. The separation of capsule from the splenic parenchyma, a thickening of the capsule, congestion in the splenic parenchyma, dilated sinusoids, and arteriolar enlargement, karyolysis in megakaryocytes and amyloid formation were determined in the low-dose group. Hemorrhage and separation in the capsule, amorphous megakaryocytes, karyolysis in megakaryocytes, congestion in the splenic tissue and sinusoidal enlargement, fibrosis, lobule formation, enlargement of the white pulp and deformation of arteriole were detected in the medium-dose group. Hemorrhage in separated capsule, karyolysis in megakaryocytes, congestion in the splenic parenchyma, enlargement of the white pulp, fibrosis, necrosis in the white pulp, congestion in the enlarged sinusoid and cellular swelling in the splenic red pulp were observed in the high-dose group. These findings clearly demonstrated that propanil induced important dose-related histopathological damages. Based on our results, we can clearly say that it may have the capacity to cause this organ’ failure.
Unraveling Cyber Threats: The Role of Forensic Investigation in Cyber Security
Authors: P A Safuwan Ali , R Kavitha
Published: June 2024

In today's digital landscape, cyber threats pose significant risks to organizations worldwide, demanding robust cybersecurity measures. Forensic investigation is pivotal in identifying, analyzing, and mitigating these threats, providing insights into their nature and impact for effective incident response. Leveraging forensic techniques and tools empowers organizations to fortify defense strategies and resilience against evolving threats. Cyber forensics encompasses diverse domains such as digital, data, system, and network forensics, crucial for legally admissible evidence presentation. System forensics focuses on standalone machine investigations, while network forensics scrutinizes network events. Data forensics involves analyzing volatile and non-volatile data, while proactive forensics facilitates ongoing evidence collection for enhanced preparedness. Email forensics addresses the evidential role of emails in forensic investigations.
Long-term anticoagulant therapy in the aspect of secondary prevention of recurrent pulmonary embolism
Authors: Shmidt E. A. , Penskaya T. Yu. , Gruzdeva O. V. , Berns S. A. , Karetnikova V. N. , Barbarash O. L.
Published: June 2024

Aim. To determine differences in laboratory coagulation parameters using routine and integral monitoring methods in patients depending on anticoagulant therapy >12 months after pulmonary embolism (PE) with a high recurrence risk.

Material and methods. The study included 72 patients who, according to indications, received long-term anticoagulant therapy >12 months due to a high risk of recurrent thromboembolism. During the follow-up period (15-20 months from the first pulmonary embolism episode), the plasma coagulation parameters were studied using a conventional panel and D-dimer assessment, as well as a thrombin generation test and thrombodynamics. Patients adherent to prolonged anticoagulation were included in group 1. During the collection period, 8 patients independently stopped taking anticoagulants, despite the high risk of recurrent pulmonary embolism (group 2).

Results. There were no significant differences in coagulation parameters and D-dimer levels between the studied groups of patients. In the group of patients continuing to take anticoagulants, there was an increase in clot growth delay parameters in comparison with patients of group 2 according to the thrombodynamics results (p=0,046) and the thrombin generation test in platelet-poor plasma in comparison with reference values (p=0,001).

Conclusion. Long-term anticoagulant therapy effectively prevents recurrent venous thromboembolism. In patients after primary pulmonary embolism who refuse anticoagulation, the clot growth delay values are shortened, which indicates an increased risk of recurrent venous thromboembolism. The most stable plasma coagulation parameters are observed in patients taking direct oral anticoagulants.
Frequency of dyspnea related to intake of ticagrelor or clopidogrel in patients with chronic coronary syndrome undergoing coronary intervention
Authors: Shnain Dunya Habeeb , Mahmood Ghassan Mohammed , Ahmed Sara Omar
Published: June 2024

In patients with chronic coronary syndrome, ticagrelor decreases cardiovascular events more efficiently than clopidogrel. In several studies investigating novel P2Y12 inhibitors dyspnea has been detected. A rise of adenosine blood levels is supposed to be one of cases of dyspnea induced by ticagrelor. Dyspnea is a prevalent and complex symptom. It is associated with deterioration of the quality of life and hospital readmission.

Aim. To determine the frequency of dyspnea related with ticagrelor or clopidogrel intake in patients with stable coronary artery disease undergoing coronary intervention. Also, to determine which patients could continue ticagrelor intake and which patients couldn’t, and show the causes of ticagrelor discontinuation.

Material and methods. Between October 2023 and January 2024, an observational prospective comparative case-control study was conducted at Baghdad Heart Center in Baghdad Teaching Hospital in Medical City. In this study, individuals with stable coronary artery disease who just had therapeutic catheterization and dual antiplatelet therapy were included. The patients from group 1 received aspirin and ticagrelor, while those from group 2 received aspirin and clopidogrel.

Results. A total of 120 patients were included. With the ticagrelor intake, the severity of dyspnea was classified as mild 64.2% (77 [120]) and moderate 19.1% (23 [120]). About 16.7% (20 [120]) had no dyspnea at all. The difference between patients who continued ticagrelor intake (16%) and those who stopped using it (84%) was significant. With clopidogrel intake no dyspnea was recorded.

Conclusions. According to our findings, the risk or occurrence of dyspnea is only evident in patients who received ticagrelor. When compared to irreversible P2Y12 inhibitors like clopidogrel, the reversible P2Y12 antagonist ticagrelor has a higher incidence of dyspnea in increasing order.
Hypertension and reduced bone mineral density: unexpected pathogenetic mechanisms
Authors: Sheptulina A. F. , Golubeva Yu. A. , Yafarova A. A. , Tsoriev T. T. , Kiselev A. R. , Drapkina O. M.
Published: June 2024

Hypertension (HTN) and osteoporosis are major age-related conditions, each of which causes significant morbidity and mortality. To date, data have been accumulated on the relationship between hypertension, markers of bone matrix formation and bone resorption. This review article discusses the relationship between hypertension and reduced bone mineral density, as well as previously unknown pathogenetic mechanisms underlying it.
Comparative assessment of long-term survival of patients after primary and recurrent myocardial infarction: a data from the RIMIS registry
Authors: Martsevich S. Yu. , Afonina O. S. , Zagrebelnyy A. V. , Sichinava D. P , Samorodskaya I. V. , Avdeev Yu. V. , Avdeeva I. Yu , Gvindzhilia T. R. , Kuzmina I. M. , Drapkina O. M.
Published: June 2024

Aim. To compare the long-term prognosis of life of patients after primary and recurrent acute myocardial infarction (MI).

Material and methods. The study was based on the RIMIS registry, which included all patients after transmural MI in 2017 in one of the Moscow vascular centers. The prospective part included 191 patients who survived the acute stage of MI, of which 145 suffered a primary acute MI, 46 — a recurrent acute MI. Long-term follow-up data were collected 71 (53;75) months after discharge from the hospital. The primary endpoint was any-cause death.

Results. During the follow-up period, 35 (25,2%) patients with a primary MI and 25 (64,1%) patients with a recurrent MI died (p<0,001). It was not possible to establish the fate of 13 (6,81%) patients, of which 7 (4,83%) were people with primary MI and 6 (13,04%) people with recurrent MI. The death risk was significantly higher in patients who had a recurrent MI compared to patients who had a primary MI: hazard ratio (HR)=3,52 (2,09;5,96), p<0,001). An unfavorable prognosis was determined not by the fact of a recurrent MI, but by the complications that resulted from a previous MI, primarily heart failure, as well as age, sex, smoking status, and hospitalizations for cardiovascular diseases in the year before the reference MI, history of angina and following comorbidities: a prior stroke, major bleeding (life-threatening gastrointestinal bleeding requiring complex surgical intervention). Patients who had a recurrent MI were significantly more adherent to follow-up and prescribed therapy.

Conclusion. Despite the modern strategy for treating MI both in the acute stage and in the long-term period, the prognosis after recurrent MI remains unfavorable. Signs negatively affecting the prognosis were sex, age, a history of heart failure and angina pectoris, and hospitalizations for cardiovascular diseases one year prior to reference MI.
Okuma Becerisi Bağlamında Çocuklar İçin Dijital (Çevrim İçi) Okuma Kulüpleri
Authors: Çıldır Burcu
Published: June 2024

Yaşanan teknolojik ilerlemeler Türkçe öğretiminde dil becerilerinin geliştirilmesinde kullanılan ya da kullanılabilecek uygulamaları geliştirmiş ve genişletmiştir. Bu uygulamalardan biri olan dijital okuma kulüpleri, teknolojik kaynaklarla süreci destekleyerek çocukların okuma becerilerinin geliştirilmesinde zengin olanaklar sunabilmektedir. Dijital okuma kulüplerinin nitelikli bir biçimde yapılandırılabilmesi ve sürdürülebilmesi için süreçte yer alan değişkenler ayrıntılı bir biçimde ele alınarak incelenmeli ve katılımcılar için uygun koşullar oluşturulmalıdır. İyi yapılandırılmış dijital bir okuma kulübü, üyelerine dijital olarak güvenli bir ortam oluştururken okuma becerisini desteklemek geliştirmek ve sürdürmek için de gereken uygulamaları sağlar. İyi düzenlenmiş uygulamalar, çocukların okuma kulüplerinde nitelikli metinlerle buluşturulmaları ve sürecin farklı kuramsal yaklaşımlarla desteklenmesi çocukların dil becerilerinin geliştirilmesinde bütüncül bir yaklaşımı getirir. Çocuklar hep birlikte bir kitabı anlamaya çalıştıklarında; konuştukça çıkarımlarda bulunur, sorular sorar, yeniden anlatır, bağlantılar kurar ve okuduklarını özetler. Tartışmalar, öğrencilerin anlamamış olabilecekleri şeylerle boğuşmalarını ve sınıfta öğretilen stratejik okuma becerilerini uygulamalarını sağlar. Dijital okuma kulübünün üyeleri birlikte bir okuma topluluğunun parçası olur ve böylece bu kulüpler çocukların okuma kültürü/alışkanlığı edinmelerini sağlar. Dijital okuma kulüpleri, kamusal okuma alanları olarak kabul edilen kütüphanelerin de kullanımını destekler. Kitaplar konusundaki kültürü geliştirerek yazarlar, yayınevleri hakkında bir kavrayış geliştirilmesine ve bireylerin kendi okuma kültürünü oluşturmasına olanak tanır. Bu kulüpler aynı zamanda öğrencilerin okuma zevki ve motivasyonunu artırarak öğretim programlarında belirtilen okuduğunu anlama becerilerinin gelişmesini sağlayabilir. Dijital okuma kulüpleri katılımcılarının sosyal ve duygusal gelişimini de destekler. Dile getirilen katkıların gerçekleşebilmesi ve çocukların dijital okuma kulüpleri yoluyla öğrenme deneyiminin bir parçası olabilmesi için çocuklara dijital öğrenme alanları sağlanmalı ve dijital okuma kulüpleri gibi uygulamaların geliştirilmesine önem verilmelidir.
Are there exclusionary reasons? An inquiry on a third kind of exclusionary reasons
Authors: Faggion Andrea
Published: June 2024

Abstract: Joseph Raz became well-known for his concept of exclusionary reasons, which he applied in the analysis of various practical concepts, such as decisions, rules and obligations. However, the scholarly literature displays a high degree of skepticism regarding the existence of exclusionary reasons and even the coherence of the concept itself. Throughout his work, Raz consistently focused on two types of exclusionary reasons: directly motivational reasons and evidential ones. The concept has faced numerous criticisms, likely stemming from this particular focus. In this article, I emphasize another category of exclusionary reasons that Raz neglected: reasons that are excluded by their very nature. I argue that this category not only shows that the concept is not empty or inconsistent, but also plays a crucial role in elucidating a significant moral domain, specifically, the domain of affective relationships.
TEACHER EDUCATION: WHICH PLACE DOES IT HAVE IN TEACHER INSERTION IN TECHNICAL SCHOOLS IN THE HEALTH FIELD?
Authors: CORRÊA ADRIANA KATIA
Published: June 2024

ABSTRACT: Introduction: higher secondary technical professional education (HSTPE) is really present in the health field, considering the great number of technical workers. Nevertheless, there are weak policies regarding teacher education. Objectives: 1. analyze which the selection criteria and methods are, regarding the education requirements as teachers and 2. connect teacher education to some aspects of the conditions of work. Methodology: a study with a dialectical and historical approach, involving document and field research. Ten (10) schools that offer technical courses in the field of health in São Paulo state took part in the study. Five (5) of these schools are public ones and the others are private, and they include branches of the Etecs - Centro Paula Souza, EtSUS, Senac, and other private schools, not only in the capital but also in the countryside of the state. The analysis of the course plans, online questionnaires, and semi-structured interviews with teachers and administrators were carried out. Conclusions: although most of the course plans and the managers indicated, primarily, the selection of teachers with a degree, special programs, or other forms of pedagogical training, there is always a dubious, uncertain, and extremely flexible aspect. The relaxed and undermined education for the teaching in the HSTPE contributes to the naturalization and the reinforcement of the aspects that converge to the deterioration of work, which needs to be contextualized, historically, in the relationships between education and the wider processes of reproduction of the capitalist society currently marked by the neoliberal ideas.
“NADA SOBRE NÓS SEM CORPO COMUM”: OUTRO PARADIGMA PARA INCLUSÃO NO ENSINO SUPERIOR?
Authors: PAGNI PEDRO ANGELO
Published: June 2024

RESUMO: O presente artigo problematiza a dimensão ética ignorada pelos saberes sobre a deficiência e as epistemes utilizadas para designar no corpo em que a deficiência se inscreve um poder desmesurado, mesmo com as conquistas obtidas pelos movimentos políticos dos corpos com deficiência, nas últimas décadas, e a sua captura pelos atuais dispositivos de inclusão no ensino superior brasileiro. Recorreu-se, para tanto, ao método genealógico e à problemática ética do enunciado “indignidade de falar pelo outro”, propostos por Michel Foucault (1990), para situar, historicamente, em que momento os movimentos políticos das pessoas com deficiência assumem, de alguma forma, esse enunciado e quais os limites de seus efeitos de poder no ensino superior brasileiro. Objetivou-se, com isso, analisar criticamente as tensões internas de tais movimentos e os indícios do escape à norma médica e à normalidade social, com o intuito de problematizar os modelos de saberes que nestas se pautaram, assim como de assinalar os poderes emergentes de um “corpo comum”, como qualquer outro, em suas lutas por uma educação inclusiva e pela justiça social. Nesse sentido, argumenta-se pela formação de um “corpo comum” no ensino superior, constituído a partir dos encontros dos saberes e das diferenças e agenciado pelo exercício de uma alteridade radical e pela mobilização dos devires minoritários do “povo que falta”, como uma possibilidade de emergência de outro paradigma de inclusão.
INFLUENCES OF PARADIGMATIC CONCEPTIONS OF SCIENCE IN TEXTS ON ECOLOGY OF UNDERGRADUATES OF BIOLOGY SCIENCES
Authors: AQUINO RAFAEL SANTOS DE , MUHLE RITA PARADEDA , FARIAS CARMEN ROSELAINE DE OLIVEIRA , LEÃO ANA MARIA DOS ANJOS CARNEIRO
Published: June 2024

ABSTRACT: This article analyzed texts by undergraduates in Biological Sciences on the ecological theme, having as reference the paradigmatic conceptions of contemporary science: complexity, systemic and Cartesian. The research context was the Ecology Practice that is a curricular component of an undergraduate course in Biological Sciences at a public university in the Brazilian Northeast. The investigation employed a qualitative and quantitative approach with the objective of identifying the influence of paradigmatic conceptions of science in the construction of meanings of ecological themes by the undergraduate students participating in the research. The methodology combined the development of conceptual schemes and Statistical Implicit Analysis (SIA), which allowed viewing the implications of complexity and depth of the relationships established between conceptual variables present in the texts. The results indicated that different ecological themes suffer different paradigmatic influences. Systemic and complex conceptions were present in themes with conservationism and environmental impact, while consumerism was linked to the Cartesian paradigm. The research also corroborated the adequacy of mixed research approaches for the science teaching area.
“VIRADA MORAL” E ENTEXTUALIZAÇÃO DO HOMOSSEXUAL COMO PEDÓFILO EM FALAS DE BOLSONARO NO CONGRESSO (2000 A 2018)
Authors: MORAIS Argus Romero Abreu de , LOPES Luiz Paulo da Moita
Published: June 2024

RESUMO no presente artigo, reportamos sobre uma pesquisa qualiquantitativa em 922 pronunciamentos — notas taquigráficas — do Deputado Federal Jair Bolsonaro na Câmara dos Deputados no período de 2000 a 2018. Como objetivos, pretendemos analisar (i) a presença de itens lexicais religiosos e militares na retórica do ódio bolsonarista ao longo desse recorte cronológico e (ii) a “virada moral” no discurso político do parlamentar, quando, a partir de 2011, passa a associar a homossexualidade à pedofilia. Para tanto, ancoramo-nos em uma metodologia de análise lexical, aproximando a Linguística de Corpus da Antropologia Linguística. Nesse intuito, distribuímos os dados em dois subcorpora, de 2000 a 2010 e de 2011 a 2018, tendo como parâmetro, em um primeiro momento, descrever o contraste diacrônico nas ocorrências de 20 palavras-chave, divididas em dez para o Discurso religioso e dez para o militar, e, em um segundo, explicar o funcionamento da entextualização do signo “pedofilia” na (re)organização da relação entre discurso de ódio, homofobia e pânico moral nas falas do político. Os pronunciamentos foram processados no programa AntConc e no Excel. A partir de 2011, o Discurso bolsonarista se associa ao moralismo religioso, equilibrando o uso de léxicos do Discurso ultraconservador militar e do Discurso fundamentalista cristão.
Sistema-mundo moderno, economia de mercado e formação do Brasil contemporâneo*
Authors: Santos Fábio Pádua dos
Published: June 2024

Resumo O presente artigo discute o processo de formação do Brasil contemporâneo nos quadros do sistema-mundo moderno através da instituição da economia de mercado como mecanismo de regulação social. Para tanto, exploram-se as formas de sociabilidade herdadas do período colonial e, então, analisam-se as tensões desestabilizadoras que envolvem o processo de homogeneização dos diferentes modos de vida através do impacto da formação do Estado brasileiro e da organização dos mercados de terra e de trabalho. Argumenta-se que o estudo da economia de subsistência é central para compreender a transição ao Brasil contemporâneo na medida em que a partir dela é possível apreender as tensões engendradas sobre e pelo Estado no processo de instituição do modo capitalista de produção da vida no Brasil.
Diversificação tecnológica nas mesorregiões do estado de São Paulo: uma análise a partir dos índices de densidade relacional e complexidade*
Authors: Françoso Mariane Santos
Published: June 2024

Resumo Esse artigo busca analisar as oportunidades de diversificação tecnológica das mesorregiões do estado de São Paulo, a partir dos índices de densidade relacional e complexidade. Considerando a importância da mudança estrutural para o crescimento e que esta pode ser entendida como um processo de ramificação, são utilizados dados de pedidos de patentes submetidos ao INPI no período de 2016 a 2020 com pelo menos um inventor brasileiro. Os resultados evidenciam a grande heterogeneidade entre as regiões do estado, sendo que poucas regiões têm oportunidades de diversificação com alta densidade relacional e alta complexidade. As distintas configurações podem ter impacto no desenho de políticas públicas. Enquanto há grande potencial para a identificação de oportunidades tecnológicas de alta complexidade e densidade relacional em algumas regiões, como a Metropolitana de São Paulo, o mesmo não ocorre na maior parte das regiões do estado, nas quais há baixa densidade relacional em tecnologias mais complexas.
Real Feitoria do Linho Cânhamo: da diversificação econômica aos desafios produtivos (1783-1824)
Authors: Rosa Lilian
Published: June 2024

Resumo A Real Feitoria do Linho Cânhamo (RFLC) foi resultado de uma política do Estado português que visava a produção de uma matéria-prima essencial para os impérios ultramarinos da época. Neste trabalho, a trajetória administrativa deste estabelecimento é compreendida dentro da organização administrativa do Estado português, sem deixar de dialogar com os poderes locais. Para isso, foram consultados documentos da RFLC, do vice-rei Luís de Vasconcelos e Sousa, dos governadores locais, do Conselho Ultramarino e dos Secretários de Estado da Marinha e Ultramar. A análise destes documentos revela que a administração da RFLC esteve subordinada a um conjunto de instituições públicas e privadas. Ao final, conclui-se que essas instituições limitaram o poder dos inspetores, relegando-os mais a um papel de adjuvantes do que de administradores capazes de fomentar o projeto em torno da RFLC.
Realizando a moral: a ética kantiana e o papel da educação
Authors: Santos Robinson dos
Published: June 2024

Resumo Neste ensaio argumentarei em defesa da ideia de que a educação moral representa um elemento de suma importância para aplicação da ética kantiana e que, apesar de o filósofo não ter elaborado uma teoria sistemática sobre o tema, ele é formulado de modo explícito em algumas obras e pressuposto de modo tácito em outras. Para isso, recorro a três aspectos que me parecem importantes na perspectiva de legitimação do tema: 1) a educação moral como direito humano fundamental; 2) sua tarefa enquanto exercício da faculdade de julgar e como fenômeno social; e 3) o papel do Estado no seu fomento. Estes três aspectos podem não cobrir tudo o que a educação moral significa para Kant, mas sem eles não é possível a sua compreensão.
Patriarcado, género y violencia: hacia una nueva masculinidad en bell hooks
Authors: Arribas Brais González
Published: June 2024

Resumen Tomando como hilo conductor de reflexión y análisis el pensamiento de bell hooks, en el presente artículo se estudia el patriarcado como una estructura ideológica que promueve y legitima diversas formas de violencia, como la opresión y la discriminación sexista. Se sostiene, además, que la violencia patriarcal no se dirige solo hacia las mujeres, sino que también lo hace hacia los hombres, en tanto las identidades de género tradicionales que son incitados a asumir fomentan actitudes y valores tóxicos. En coherencia, se afirma que para erradicar la violencia sexista y para edificar una sociedad más justa e igualitaria, se requiere la conformación de nuevas subjetividades de género, que sean alternativas a la hegemónica y que estén descolonizadas del ideario patriarcal. En tal sentido, se estudia la propuesta de hooks para edificar una nueva masculinidad más solidaria, comprensiva y afable que la tradicional.
Liderazgo pedagógico moral: percepciones del alumnado de secundaria
Authors: Zárate Zaida Espinosa , de la Hoz Jesús Plaza
Published: June 2024

RESUMEN El presente artículo analiza las percepciones del alumnado de 4º de Educación Secundaria sobre su perfeccionamiento moral para ver qué tipo de liderazgo pedagógico moral valora. En particular, examina qué peso tienen los docentes en su desarrollo moral, en comparación con otros contextos, y qué estrategias emplean los docentes con más impacto moral en el alumnado. Para ello, se administró un cuestionario a 131 estudiantes españoles cuyos resultados fueron analizados mediante SPSS y MAXQDA. Además del impacto familiar esperado, se muestra que los adolescentes reconocen el influjo moral del docente, sobre todo en materias de tipo humanístico, y valoran rasgos del carácter del profesorado relacionados con la cercanía, empatía y afecto por encima de metodologías centradas en lo tecnológico. Ello sugiere la necesidad de reforzar la dimensión emocional y afectiva en la orientación psicopedagógica de los docentes para forjar la clase de vínculo que un liderazgo de este tipo requiere.
Evaluation of flowability of cementitious self-leveling pastes by varying the superplasticizer and viscosity modifying admixture
Authors: Guimarães Paula Aguilar , Pinto Maria Clara Cavalini , Tamura Sarah Honorato Lopes da Silva , Martins Eliziane Jubanski , Costa Marienne do Rocio de Mello Maron da
Published: June 2024

Abstract To meet the self-leveling pastes’ performance requirements, its flowability is linked to the absence of segregation or exudation, which makes a high cohesion between the components mandatory. Therefore, the ideal dosage for these materials is an essential topic to provide such specific properties. To evaluate the composition effect on fresh state, a method was proposed to quantify self-leveling pastes’ uniformity through the analysis of the spread pastes’ diameter and borders. Thus, different dosages were tested varying some input contents. The uniformity was quantified with the development of indexes such as Perimeter Ratio (PR) and Input Relation (IR). It was concluded that lower spread diameters incurred in higher uniformity index. Furthermore, it was observed that to achieve an ideal dosage for pastes, there is a tendency of direct correlation between the uniformity index and the water/powder ratio (w/p) and superplasticizer (SP) content and an inverse one between it and viscosity modifying admixture (VMA).
‘HOLIDAYS ARE HOLIDAYS, RIGHT? ‘BRAZILIAN LECTURERS’ PERCEPTIONS OF THE RELATIONSHIP BETWEEN PROFESSIONAL AND PERSONAL LIVES
Authors: Matos Mayara , Sanderson Rebecca , Costa Filho Roraima Alves , Iaochite Roberto Tadeu
Published: June 2024

The work-life balance in higher education has been extensively studied but understanding of the academic work culture in the Global South, specifically in Brazil, is limited. This article explores Brazilian lecturers' perceptions of the interface between professional and personal life. Drawing on 516 responses to a questionnaire about using non-work time for academic tasks, and referencing the philosopher Byung-Chul Han and sociologist Lewis Coser, five key themes are generated which make a valuable contribution to this gap: complexity of tasks and environments, excessive dedication, strategies of adaptation, costs of adaptation, and strategies of resistance. Academics in Brazil grapple with intricate workloads in environments that often don't bolster their efforts, resulting in blurred boundaries between their professional and personal lives. Some view their roles with a vocational passion or derive pleasure from their tasks, while others are besieged by their professional demands. This dedication can lead to guilt, affecting both personal relationships and wellbeing. To navigate these challenges, many adopt rigorous planning, yet the perpetual encroachment of work responsibilities can induce exhaustion, stress, and health complications. A segment of academics, influenced by significant life events, resort to strategies emphasizing the delineation between work and leisure, often treating holidays as sacrosanct periods of rest. This study underscores the need for self-awareness and individualized strategies to manage work overload. and calls for a broader challenge to the prevalent culture of productivism in academia and its ramifications on university life. Underpinning the discussion, is the “Health promoting universities” as a possibility for future changes and health promotion for all academic community.
Explorando Barreras de Aprendizaje y Participación en Estudiantes Universitarios con TEA: Un Estudio Cualitativo
Authors: Rivera William José Crespo
Published: June 2024

Este estudio cualitativo examina las barreras de aprendizaje y participación experimentadas por estudiantes universitarios con Trastorno del Espectro Autista (TEA). Mediante entrevistas en profundidad, se exploraron las experiencias y percepciones de los estudiantes con TEA en el ámbito académico. Los resultados revelaron diversas barreras, como lo son barreras culturales y prácticas. Estas barreras afectan negativamente la satisfacción académica de los estudiantes, y participación en el entorno universitario. El estudio destaca la importancia de crear un ambiente inclusivo y proporcionar apoyo adecuado para promover el éxito académico de los estudiantes con TEA. Los hallazgos de esta investigación ofrecen una base sólida para desarrollar estrategias y políticas que mejoren la experiencia educativa de este grupo de estudiantes en las instituciones de educación superior.