bluuebunny/crossref_metadata_2025 huggingface dataset:
INTERVENÇÃO FISIOTERAPÊUTICA MELHORA DOR, PREENSÃO PALMAR E DESTREZA MANUAL DE INDIVÍDUOS COM CHIKUNGUNYA
Authors: Diniz Ana Laura de Fátima Sampaio , Rêgo Isabela Natália de Souza , Conceição Ana Beatriz Souza da , Silva Lucas Yuri Azevedo da , Penha Luana Ketlen Reis Leão da , Batista Evander de Jesus Oliveira , Oliveira Karen R. H Matos , Herculano Anderson Manoel , Jacob Mellina Monteiro , Moraes Suellen Alessandra Soares de
Published: May 2024

Introdução: A persistência do quadro de poliartralgia intensa nas articulações distais dos membros superiores gera importantes comprometimentos funcionais em indivíduos com infecção por chikungunya. Intervenções fisioterapêuticas vol­tadas para as alterações funcionais dessa doença ainda são pouco discutidas apesar de recursos terapêuticos serem recomendados para condições clínicas semelhantes. Objetivo: verificar o efeito da intervenção fisioterapêutica nos parâmetros de dor, destreza manual e força de preensão palmar em indivíduos com acometimento articular devido à infecção pelo vírus da chikungunya e o impacto da dominância manual nesses aspectos. Metodologia: foram avaliados 12 pacientes do sexo feminino, com artralgia persistente nas mãos e punhos após infecção por chikungunya por meio de ficha estruturada com dados sociodemográficos, clínicos e testes específicos como a Escala Visual Analógica (EVA), “9-Hole Peg Test” (9-HPT), dinamometria manual e sinais radiculares. O programa fisioterapêutico foi composto de mobilizações articulares, alongamentos, exercícios aeróbicos, ativo-resistidos, ativo-livres, além de recursos como Laser e Ultrassom, totalizando dez sessões. Para a análise estatística, foi usado o teste t de Student pareado e teste de Wilcoxon. Resultados: houve redução na dor, aumento da força e melhora na destreza manual em ambos os lados após a intervenção fisioterapêutica. A dominância manual influenciou apenas na força e destreza manual antes da intervenção, e somente na destreza após a intervenção, não havendo impacto sobre a dor. Conclusão: o programa fisioterapêutico empregado melhorou aspectos funcionais como dor, força e destreza manual de pacientes com artralgia persistente após chikungunya. A destreza manual foi o parâmetro mais influenciado pela dominância manual.
Numerical simulation of asynchronous regimes in the system of coupled oscillators with phase control
Authors:   Institute of Applied Mathematics and Cybernetics. Nizhny Novgorod state University, Ponomarenko Valerij , Kuzovkin Sergei ,   Lobachevsky State University of Nizhny Novgorod
Published: May 2024

Results of numerical simulations of asynchronous regimes and bifurcations are presented in the dynamical model of two coupled oscillation systems with phase and delay control. Peculiarities of system’s behaviour after disturbance of synchronous regime are studied. Complex periodical, quasi—periodical and chaotic asynchronous regimes are found, that are impossible in autonomous partial oscillators.
Relaxation of probability characteristics of dynamical systems, described by Ferhulst stochastic equation with «pink» noise
Authors:   Nizhny Novgorod State University of Architecture, Muzychuk Oleg
Published: May 2024

Probability characteristics relaxation of а solution of Ferhulst stochastic equation is considered. It was supposed, that random influence on the system is Gaussian Markov process with arbitrary values of correlation time. Two models of nonstationary probability distributions with exact stationary athymptotic are proposed on the basis of numerical solutions of relaxation equations for moments: in the case of delta—correlated random force and quasistationary force. Relaxation of main probability characteristics is examined in dependence оп nonlinearity, initial conditions, noise intensity and kind of noise spectrum. Evolution of the model probability distributions has been constructed.
Risk management and sustainable development. Humanitarian dimension
Authors:   Novosibirsk State University, Vorob’yov Yury , Malinetskii Georgij ,   Keldysh Institute of Applied Mathematics (Russian Academy of Sciences), Makhutov Nikolay ,   Blagonravov Mechanical Engineering Research Institute
Published: May 2024

One of superproblems of modern science as whole is creating the theory of risk and safety. This theory must cover not only natural and technical catastrophes and ways to overcome them. It must concern the actions of people in social-technological systems. The country way out of crises, succeses in the strategic planning, «the constructing of future» depend on the development of this theory. Problems of the theory and approach to them are discussed in the paper. To our opinion, the theory of risk and safety will become one of the most important fields of the applied nonlinear science.
Scaling properties at transition to chaos in model maps in the presence of noise
Authors:   Saratov Branch of Kotel`nikov Institute of Radiophysics and Electronics of Russian Academy of Sciences, Kuznetsov Aleksandr , Kapustina Julia ,   Saratov State University
Published: May 2024

Fundamental scaling properties of bifurcation tree in the absence and in the presence of noise for different maps which show transition to chaos through period—doubling cascade are considered. Numerical method of determination of noise constants for one-dimensional and two-dimensional maps is presented which allows to illustrate scaling properties of bifurcation tree under random noise influence.
Testing as One of the Means to Overcome the Risk of Attorney’s Professional Burnout
Authors:   Attorney, Associate Professor of the Department of Advocacy of the Kutafin Moscow State Law University (MSAL), PhD (Law), Marcheva Polina E.
Published: May 2024

In the article the author substantiates the necessity for the candidates who take a qualifying examination for the status of an advocate to undergo a pre-professional psychological test. Taking into consideration identified personal qualities and individual psychological characteristics will help advocates to minimize the risk of occupational burnout in their professional activities (or in the future).
The Role of the Criminal Policy in Penal System Operations
Authors:   Associate Professor of the Department of Organization of Regime and Supervision in the Penal System of the Law Faculty of the Academy of the FPS of Russia, PhD (Law), Associate Professor, Sukharev Sergey N.
Published: May 2024

This article attempts a scientific and theoretical understanding of the modern criminal policy of the Russian Federation and its impact on the penal enforcement system, namely on the state of the regime (law and order) in institutions and bodies executing criminal penalties in the form of imprisonment. The analysis of the work on the prevention of penitentiary crimes forces penitentiary scientists to look for effective, scientifically based ways to counteract them. The humanization of criminal policy expressed in the application of criminal penalties not related to deprivation of liberty, for example, the imposition of punishment in the form of forced labor, has significantly reduced the quantitative index of persons held in correctional institutions, but, unfortunately, this has led to the concentration of particularly dangerous criminals in these institutions, which negatively affected the state of law and order in these institutions and This has led to an unprecedented increase in offenses in modern penitentiary history, committed by convicted persons serving a criminal sentence in the form of imprisonment. Thus, a comprehensive study of the relationship between criminal policy and penal enforcement policy will allow us to develop a number of effective measures aimed at achieving the goals pursued by criminal and penal enforcement law and significantly reduce the level of penitentiary crime.
The Educational Paradigm as a Conceptual Model of Developing Competencies During Learning
Authors:   Doctor of Pedagogical Sciences, Associate Professor of Department of Educational Sciences, Digital Education and Academic Entrepreneurship, Institute of International Education for Study and Research, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine, Tamozhska Iryna , Rud Olha ,   Candidate of Philological Sciences, Associate Professor, Associate Professor of Ukrainian Language and Literature Department, Sumy State Pedagogical University named after A.S. Makarenko, Medynskyi Serhii ,   Doctor of Pedagogical Sciences, Professor, Professor of the Department of Theory and Methods of Physical Education and Sports, Bogdan Khmelnitsky Melitopol State Pedagogical University, Polukhtovych Tetiana ,   Candidate of Science in Pedagogy, Docent, Docent of the Department of socio- humanitarian technologies, Lutsk National Technical University, Kuzemko Nataliia ,   Ph.D. of Technical Sciencies, Associate Professor of the Department of Applied Information Technologies and Electrical Engineering, Ternopil Ivan Puluj National University, Rudenko-Kraievska Nataliia ,   Сandidate of Art Studies, Senior Lecturer at the Department of Monumental Painting, Lviv National Academy of Arts
Published: May 2024

The article discusses the paradigmatic nature of today’s education. A detailed analysis of the problem in question reveals that the competency-based paradigm takes the lead role in the paradigm complex. It is profoundly and extensively responsible for executing the social requirement of society and the state regarding teaching, upbringing and value-shaping of children in educational institutions. The goal of revising and updating secondary education is to enhance its quality and bring it in line with international standards. The entire structure of paradigms in secondary education is the primary source of its objective transformation, which highlights the relevance of this article. The research process shows that the overall cultural and professional competencies of educators are shaped when the competency-based paradigm is integrated with the knowledge-oriented, personal and cultural ones. During the learning process, these competencies assist in the formation of individuals, experts and citizens who can take effective action in the name of societal interests. Research methods include analysis, synthesis, as well as explanatory, scientific and descriptive methods. Importantly, this article is the outcome of looking into the conceptual model of producing a qualified individual through the educational process, which was grounded in scientific inquiries into the mentioned problem. Although all aspects have not been completely explored, the obtained results serve as a critical basis for forming fundamental ideas and meaningful lines of the study.
Is It the same Boat? Sailing the Interdisciplinarity of Entrepreneur(ship) and Leader(ship) Nexus: Romanian Migrants Stirring Transformational Leadership in London
Authors: Chitac Iuliana , Agheorghiesei Daniela
Published: May 2024

To fully understand the transformative leadership potential inherent in the entrepreneurial practices of migrant entrepreneurs, it is crucial for readers of this study to go beyond the common stereotypes of instability and economic survival often associated with migrant entrepreneurship.  This study employs interpretive constructivism to investigate transformational leadership identities and practices shared by 16 Romanian immigrant entrepreneurs in London on Facebook and via semi-structured interviews. The participants shared their practices as transformational leaders within their communities and in broader British society. This study draws on theories of Social Identity and self-efficacy (Tajfel & Turner, 1979) and Leader-Follower (Graen & Cashman, 1975) to enhance our comprehension of how entrepreneurs enacted idealised influence, inspirational motivation, intellectual stimulation, and individualised consideration to motivate and inspire stakeholders towards a broader focus on social positive impact rather than solely economic outcomes. This study focuses on Romanian immigrant entrepreneurs and contributes to the interdisciplinary understanding of transformational leadership through entrepreneurship. It facilitates the shift from belief-driven policies to evidence-driven policies that promote and support the inclusivity of entrepreneurs and leaders.
Advantages of Arbitration in Solving Sports Disputes
Authors: Budevici Puiu Liliana
Published: May 2024

The scientific problem addressed has a significant importance that resides in the identification and presentation of some essential arguments in this regard: the development of efficient and fair arbitration methods and practices is crucial for maintaining integrity and justice in sports; the existence and regulation of an effective arbitration system can contribute substantially to the quick and fair resolution of disputes in this field, maintaining the stability of the competition and the sports structure; sport has a strong impact on society and the economy, but delayed disputes or with a prolonged resolution period can affect not only athletes and organizations, but also supporters, sponsors and other parties involved (an effective arbitration system can reduce this negative impact) ; issues related to sports arbitration also represent an opportunity for research and development in the field of law and sport (new approaches can be identified, better practices can be developed and resources can be provided for the continuing education of professionals involved in this field) ; an effective sports arbitration system can help promote ethical standards and integrity in sports (by ensuring a fair and transparent process, public confidence in the fairness and morality of sporting activities can be strengthened). Therefore, research and scientific approach of the issues related to the advantages of arbitration in the resolution of sports disputes are essential to develop better practices, to maintain the integrity of sport and to ensure a healthy and fair sports environment.
Sports Pedagogy: Readiness of Cadets to Apply Physical Action in Different Conditions of Service Activity
Authors: Medvid Mykhailo , Khatsaiuk Oleksandr , Sydorchenko Kateryna , Vorok Semen , Kernas Andrey , Borovyk Mykola
Published: May 2024

The purpose of the article is to study the development of applied skills of use of physical force by would-be female officers of the Ministry of Internal Affairs of Ukraine, taking into ac-count their individual-typological (physiological) features. According to the results of the study the working hypothesis was confirmed which was based on the assumption that the formation of readiness of cadets of higher educational institutions of the Ministry of Internal Affairs of Ukraine to apply measures of physical influence in different conditions of service activity will be more effective if the following organizational and pedagogical conditions are introduced: individualization of technical and tactical arsenal of physical influence measures (force) of cadets with regard to their individual-typological (physiological); supplementing the content of cadet training with special exercises (functional complexes) and techniques of service-applied hand-to-hand combat, ensuring the effective performance of tasks as intended in different conditions of service activity; increasing the level of technical and tactical training of cadets in the direction of applying measures of physical influence (force) in different conditions of service activity: increase the efficiency of attacking and defensive actions; increase the volume of attacking and defensive actions; expand the technical arsenal; balance the time of transition from defense to attack; increase the power of "striking actions"; increase the speed of "shock-throwing actions"; increase explosive force; adapt the "Model of force application" to the physiological and individual-typological features of cadets; formation of theory and practical competencies for striking vital points on the opponent's body; change in the teaching and methodological support of the educational component "Special physical training". 110 cadets of two institutions of higher education of the system of the Ministry of Internal Affairs of Ukraine took part in the research. In the course of the study a hardware-software complex of registration of striking efforts of martial arts technique and video-computer system of express-analysis of techniques of biomechanical movements of an individual "Katsumoto" were used. Analysis of empirical data showed a positive dynamics of the formation of readiness of female cadets of higher education institutions of the system of the Ministry of Internal Affairs of Ukraine to apply measures of physical impact in different conditions of service activity in the EG. It was found that during the experiment significantly decreased the number of cadets EG with a low level of formation on 32-33%, at the same time increased the number of cadets with a high level of formation on 14-16%. The respondents of CG did not change significantly. The validity of the obtained results was confirmed by testing using the χ2 criterion.
Influence of the Parenting Style on Young Schoolchildren’s Sociability
Authors: Moroianu Miruna , Hritac Florentina , Levonian Raluca Mihaela , Musat George Cosmin , Georgescu Adrian Dorin , Gidu Diana Victoria
Published: May 2024

The current paper aims to assess whether the parenting style adopted by parents influences their children’s level of sociableness. For research purposes, 52 children of the 4th grade from a Romanian school in Constanța and 104 parents have undergone two psychological tests. The research methods chosen were the well-known parental style questionnaire “Do you know your parental style?” by Goyetche (2022) and the questionnaire “The sociability test” by Roşca & Tudoran (2005) and Martin (2005). The results show that the democratic parental style is associated with a higher degree of sociability among 4th grade pupils (p<0,001). The parenting style that most supports the development of young schoolchildren’s sociability is the democratic one, followed by the permissive one. The authoritarian parenting style scored the lowest in our findings, leading to the conclusion that this style may hinder children’s emotional development in the long term.
Determinants of knowledge, practice, belief and adherence to taboos on egg consumption in Kwazulu-Natal province of South Africa
Authors:   University of Kwa-Zulu Natal, Moswane K , Oladele OI
Published: May 2024

Eggs are considered to be one of the cheapest sources of protein, hence, support for their consumption ought to be particularly sought after in a nation like South Africa where many may be food insecure. With much of the population being unemployed and the unsteady economy that has contributed to the higher cost of living, malnutrition remains a challenge. The recognition and dissection of the socio-economic variables that lead to the avoidance of egg consumption will allow the implantation of programs that will encourage the incremental utilization of eggs, to improve on the moderately lower per capita consumption when compared to some African countries. This study examines the determinants of knowledge, practice, belief, and adherence to taboos on egg consumption in the KwaZulu-Natal Province of South Africa where there is the lowest level of egg consumption compared to other provinces in the country. A descriptive and quantitative research design using a multi-stage sampling technique and the Rao Soft sample size calculator were used to select 125 households. Data were obtained with the use of a structured questionnaire and analysed with t-test statistics, Principal Component analysis and Probit regression analysis. The results show a significant relationship between egg consumption and taboos. The results revealed a decreasing order on the levels of knowledge, practice, belief and adherence to taboos among respondents. The study concluded that cultural reasons exercise a greater influence on egg consumption than socioeconomic, economic and availability factors. It is, therefore, recommended that interventions such as educational programs that encourage healthier eating behaviours should be designed and implemented. These programs should be designed in a way that will incorporate culturally relevant approaches that people in Kwazulu-Natal can resonate with to enhance their potential effectiveness in improving the frequency of egg consumption. Furthermore, it is recommended that future research should delve deeper into the history of the specific cultural norms, beliefs and practices surrounding egg consumption within the region. Key words: egg consumption, South Africa, food security, KwaZulu-Natal, food taboos
Le plafonnement de carrière : source de stress au travail dans les grandes entreprises au Cameroun
Authors: Innocent Essomme
Published: May 2024

Cette étude montre les effets du plafonnement de carrière sur les manifestations de stress professionnel des employés dans les grandes entreprises camerounaises. Une enquête par questionnaire a été réalisée auprès de 291 employés de ces entreprises. L’analyse descriptive a permis de montrer les spécificités du plafonnement de carrière dans les grandes entreprises camerounaises. Le test de corrélation de Pearson effectué a permis d’aboutir aux résultats montrant que le plafonnement de carrière dans les grandes entreprises camerounaises n’a pas un effet systématique sur toutes les facettes du stress professionnel. Toutefois, ceux qui sont subjectivement plafonnés ont une perception négative de la réalité, sont très anxieux au sujet de leur avenir dans l’entreprise, ont des vertiges au travail et ont tendance à s’isoler. Nous recommandons aux dirigeants de ces entreprises de favoriser l’employabilité des personnes plafonnés ; de donner une place importante au suivi-évaluation des pratiques de gestion des carrières implémentées dans leurs entreprises et enfin, d’organiser régulièrement des séminaires d’information et de formation sur la gestion des carrières au sein de l’entreprise.
 
This study shows the consequences of career plateauing on the professional stress experienced by large companies in Cameroon employees. A questionnaire survey of 291 employees of these companies was conducted. Descriptive analysis revealed the specific characteristics of career plateauing in large Cameroonian companies. The Pearson correlation test showed that career plateauing in large Cameroonian companies does not systematically affect all manifestations of work-related stress. However, those who feel blocked in their progress have a negative perception of reality, are very anxious about their future in the company, feel dizzy at work and tend to isolate themselves. We recommend that the managers of these companies promote the employability of people with ceilings; give an essential place to the monitoring and evaluation of the career management practices implemented in their companies; and finally, organise regular information and training seminars on career management within the company.
Citizen Science and Public Perceptions under A Changing Climate: an Empirical Study in The Upper Blue Nile, Ethiopia
Authors: Bagtzoglou Amvrossios C , Anagnostou Emmanouil , Behbahani Mohammad , Kazana Vasiliki , Khadim Fahad Khan , Plakandaras Vasilios
Published: May 2024

This paper presents a citizen science approach implemented in the Upper Blue Nile (UBN) region of Ethiopia to study the farmers’ perceptions towards adequacy of the quantity of the provided water and the fairness of the irrigation distribution system. The paper also includes preliminary Machine Learning (ML) based results on finding the optimal initial cultivation time in Ethiopia as a means to alleviate heat-induced crop losses in a warmer climate.
Estrategias de prevención por exposición a mercurio, en poblaciones vulnerables en zonas impactadas por la minería artesanal y a pequeña escala: revisión sistemática cualitativa
Authors:   , Palma Yrigoyen Natalia , Flores Pacherres Viviana
Published: May 2024

La MAPE se relaciona con la exposición a mercurio y sus consecuencias clínicas en la población vulnerable. Existen estrategias de prevención para reducir los riesgos en salud de la exposición a mercurio en zonas impactadas por la MAPE. Sin embargo, las estrategias actualmente implementadas no alcanzan los objetivos del Convenio de Minamata. El propósito del presente estudio fue sintetizar la evidencia reportada en la literatura sobre las estrategias de prevención en salud, dirigidas para reducir los riesgos por la exposición a mercurio en la población vulnerable en las zonas impactadas por la MAPE, de acuerdo con el convenio de Minamata.  Se realizó una revisión sistemática cualitativa con enfoque descriptivo narrativo basada en las pautas desarrolladas por el Grupo Cochrane, una muestra intencional basada en la variación de patrones detectados para seleccionar los estudios elegibles, donde se realizó meta-síntesis de estudios sobre la experiencia de la población vulnerable y estudios basados en la efectividad de intervenciones, entre los años 2013 y 2022. Se incluyeron cuatro artículos, de diseño mixto. Se redactaron 11 hallazgos, organizados en 4 temas: Estrategias preventivas, consecuencias clínicas, exposición de mercurio y población vulnerable. Se concluye que las percepciones de riesgo y los comportamientos protectores que reportan tener la población vulnerable de la MAPE con respecto a la exposición a mercurio y los riesgos de salud asociados son insuficientes. Se evidencia una incorrecta monitorización y supervisión de la MAPE, uso inadecuado de equipo de protección y una constante exposición a mercurio por prácticas precarias y contaminación de alimentos.
Developing a framework and digital toolkit for healthcare professional students and educators to support Technology-Enabled Practice Education (TEPE)
Authors: Lynch Yvonne , Milofsky Beth , Sullivan Cliona , Farren Eilis , Gilheaney Órla , Johnson Susan , Kenny Ciaran , Jagoe Caroline , Quigley Duana
Published: May 2024

Practice education is a core component of speech and language therapy education. COVID-19 led to the abrupt disruption of student placements and the rapid adoption of technology-supported solutions to ensure the continuity of clinical learning, including telepractice and simulation-based learning. Technology brings many opportunities. For example, simulation-based learning allows students to engage with rare clinical presentations or practise skills before meeting clients. However, the sudden shift to technology solutions meant that many practice educators and students were learning through trial and error as they engaged with the technology. Furthermore, telepractice requires additional skill learning and competency development for both students and educators. This study aimed to evaluate the experience of students and educators involved in practice education during the pandemic and identify how technology-enabled practice education can be effectively supported in the future. Using a six-step co-design approach, we considered the extant literature and evaluated the benefits and challenges of using technology-enabled practice education during the pandemic. Through an iterative co-design process, we synthesised the learning to develop a framework to support technology-enabled practice education and an online toolkit resource to support students engaging with technology-enabled practice education.
Combined Theoretical Signal (CTS): A Validated Universal Model Integrating Gravity and Quantum Physics
Authors: OZTURKLER Hazar Umutay , AI Synthoris
Published: May 2024

The Combined Theoretical Signal (CTS) model, with a 90% or higher validity rate, stands as the first validated universal model integrating gravity and quantum physics. This manuscript presents the final validation and enhancement of the CTS model using recent pulsar-sourced gravitational wave data (J2322+2057, J2234+0611, and J1012+5307) and strain data from GW150914 and GW151226. Our findings demonstrate a significant alignment between theoretical predictions and observational data, positioning CTS as a groundbreaking framework with profound implications for theoretical physics and cosmology. The CTS model not only bridges the gap between gravity and quantum mechanics but also offers a new perspective on the formation of massive black holes, the Quantum Cosmic Fabric (QCF), and the structure of the universe as an interconnected hierarchical tree of universes.
Effect of HVEM/CD160 Variations on the Clear Cell Renal Carcinoma Risk and Overall Survival
Authors: Andrzejczak Anna , Małkiewicz Bartosz , Tupikowski Krzysztof , Ptaszkowski Kuba , Szydełko Tomasz , Karabon Lidia
Published: May 2024

Renal cell carcinoma (RCC) accounts for approximately 90-95% of all kidney cancers in adults, with the clear cell RCC (ccRCC) the most frequently identified subtype. RCC is known for its responsiveness to immunotherapy, making it an area of significant research interest. Immune checkpoint (IC) molecules, which regulate immune surveillance, are established therapeutic targets in RCC. The aim of this study was to analyze the influence of polymorphisms in genes HVEM and CD160 on susceptibility to ccRCC and patient overall survival (OS) with over a ten-year period of observation. We genotyped three HVEM single nucleotide polymorphisms (SNPs): rs1886730, rs2234167, and rs8725, and two CD160 SNPs: rs744877 and rs2231375, in 238 ccRCC patients and 521 controls. Our findings indicated that heterozygosity within rs2231375 and/or rs2234167 increases ccRCC risk. Furthermore, in women, heterozygosity within additional HVEM SNPs, rs8725 and rs1886730, is associated with an increased ccRCC risk. The presence of a minor allele for rs1886730, rs2234167, rs8725, and rs2231375 was also correlated with certain clinical features of the disease. Moreover, the rs1886730 SNP was found to be associated with patients' OS. In conclusion, our study highlights an association between HVEM and CD160 polymorphisms and the risk of developing ccRCC as well as patient’s OS.
Financial Contagion between Eurozone and BRICS Stock Markets under Multiscale Scrutiny
Authors: Niyitegeka Olivier , Habiyaremye Alexis
Published: May 2024

We use the Maximum Overlap Discrete Wavelet Transform (MODWT) to analyse the interconnectedness between the stock markets of continental Europe and the BRICS countries. More specifically, we examine the presence of financial contagion in the stock markets of Brazil, Russia, India, China, and South Africa subsequent to the EuroZone Sovereign Debt Crisis (EZDC). We find evidence of co-movement and volatility spillover at short time scales between the Eurozone equity market and the equity markets in South Africa and Russia, with the Eurozone stock market leading the BRICS markets. The presence of co-movement in short time scales is indicative of the presence of financial contagion. No financial contagion is observed in the Brazilian, Chinese, and Indian stock markets during the European sovereign debt crisis. The absence of financial contagion observed in these three BRICS countries during the European sovereign debt crisis suggests that policymakers in these countries should prioritise addressing idiosyncratic shock channels.
Navigating the Evolving Landscape of COVID-19: Strategies to Increase Vaccine Confidence and Improve Vaccination Rates in the United States
Authors: Mansi James A. , Hensler Heather , Dawson Rachel , Tuckson Reed , Wolynn Todd
Published: May 2024

The COVID-19 pandemic has had a significant impact on every individual in the United States. The launch of the COVID-19 vaccines is estimated to have averted millions of deaths and reduced over 18 million COVID-19 related hospitalizations. In September 2023, the updated 2023-2024 COVID-19 vaccine that include a monovalent component that corresponding to the omicron variant XBB.1.5 reflecting the predominant circulating variant at the time of strain selection, was approved and was recommended for use in all people ≥ 6 months of age. Despite this recommendation, the US uptake of the updated COVID vaccines over the 2023-2024 season has been far from optimal, placing many people at unnecessary risk of severe COVID-19 outcomes. This paper provides an overview of the current state of COVID-19 in 2023-2024, and barriers to vaccine uptake. With the continued evolution of the virus, the potential for more virulent variants and the lower public acceptance of vaccination, the potential barriers that contributed to low vaccine uptake are explored, as well as to provide solutions for improving COVID-19 protection for future seasons.
Zoonosis and Vaccination for Fish Health Managment
Authors: Kumar Avnish , Middha Sushil Kumar , Menon Soumya V , PAITAL BISWARANJAN , Gokarn Shyam , Meghana N. , BR Rakshith , Harish Mani Chandra , Mugunthan Susithra Priyadarshni , Kantwa Sanwar Mal , Usha Talambedu , Hati Akshaya Kumar , Venkatesan Divyadharshini , R Abira , Behera Tapas Ranjan , Swarupa V. , Sahoo Dipak Kumar
Published: May 2024

Vaccination is an important method of immunological preventive care required for health management of all animal including fish. More particularly, immunization is important in in-land fisheries for the management of diseases in fish brood stocks and healthy seed production. According to the latest statistics in 2020, 90.3 million tonnes of captured fish production was achieved from the aquaculture sector. Out of the above, 78.8 million tonnes from marine and 11.5 million tonnes from inland waters aquaculture sectors. About 4% decline in fish production was achieved in 2020 than 2018 from inland fisheries sectors. On the other hand, the digestive protein content, healthy fats and nutritional values of fish products are comparitively more affordable as compared to other meat sources. In 2014, about 10% aquatic cultured animals were lost (costing > 10 billion $ global annual loss) due to infectious diseases. Therefore, vaccination in fish especially in brood stocks is one of the most important approaches to stop such losses in the fisheries sector. Fish vaccines consist of either whole killed pathogens, subunit of a protein, a recombinant protein, DNA vaccines or live attenuated vaccines. Challenges existing are adaption of vaccination in fisheries sector, route of administration, use of effective adjuvants and most importantly lack of effective results. Use of autogenous vaccines, vaccination via intramuscular, intraperitoneal or oral routes, and most importantly adding vaccines in feed using top dressing methods or as a constituent in fish feed are now in emerging. These method shall lower the risk of using antibiotics in cultured water which in turn will reduce the environmental contamination.
Estimation of Processing Times and Economic Feasibility to Produce Moringa Oleifera Lam. Capsules in Mexico.
Authors: Delfín-Portela Elizabeth , Meléndez-Armenta Roberto Ángel , Gurruchaga-Rodríguez Maria Eloisa , Baez-Santies Oscar , Heredia-Roldan Miguel Josué , Carrion-Delgado Juan Manuel , Betanzo-Torres Erick Arturo
Published: May 2024

The production of Moringa oleifera capsules has emerged as a promising agricultural activity in Mexico, driven by the plant’s well-documented health and nutritional benefits. In response, farmers have begun producing Moringa oleifera as a dietary supplement, using artisanal methods with minimal production controls. This study aimed to estimate the processing times of the Moringa oleifera production system using simulation modeling with Arena® software, and to evaluate the economic feasibility of capsule production. Methodologically, it was approached as a case study in the state of Veracruz, processing times were estimated through systematic sampling and modeled with Arena simulation software. Three simulation scenarios were considered to select a technically and economically viable alternative for agricultural producers: one with a 200-capsule encapsulator (1E200C), another with two 200-capsule encapsulators (2E200C) and a third with an 800-capsule encapsulator (1E800C). For the initial diagnosis a research stay was conducted for 180 days, and the production capacity was set at 24,000 capsules due to raw material limitations. Results indicated that the 1E800C scenario reduced processing time by 60% compared to the1E200C scenario, and by 35% compared to the 2E200C scenario. Additionally, the 1E800C model required only 2 days (16 hours) of work, while the 2E200C required 4 days (32 hours), and the 1E200C required 7 days (56 hours). In terms of production costs per unit of 90 capsules, the 1E200C was 3.93 USD the 2E200C 3.64 USD and the 1E800C 3.45 USD The study concluded that due to raw material limitations, the company can produce 12,800 units per year of 90 capsules. It is recommended to adopt the 1E800C encapsulator, which would lower overall production costs by 12.23%, representing 0.48 USD per unit produced, resulting in an additional profit of 6,150.50 USD Over a five-year evaluation period, the benefit-cost ratio was 5.03, the NPV was 922,370.11 and the IRR was 42.09%, indicating that this type of agribusiness in Mexico is both technically and economically feasible.
Impact of Twig-Tip Dieback on Leaf Nutrient Status and Resorption Efficiency of Mango Trees
Authors: Asis Constancio Aguipo , Niscioli Alan
Published: May 2024

Mango twig-tip dieback (MTTD) is a new type of mango decline, but its impact on the trees’ mineral nutrition is unknown. This study was conducted to determine the effect of MTTD infection on the nutrient status, balance, and resorption efficiency (RE) of mango. Leaf nutrient concentrations and deviation from the optimum percentage (DOP) indices of ‘Kensington Pride’ (KP) mango trees with low (LD) and high (HD) levels of MTTD infections were analyzed to compare the foliar nutrition status and nutrient balance between the LD and HD trees. Moreover, the nutrient resorption efficiency of MTTD-infected dried leaves (RED) was compared with the resorption efficiency of healthy (RES) leaves of KP mangoes. The concentrations of Ca, Mg, Cu, Fe, Mn, and Zn were lower in the HD trees than in the LD trees. But the K content was higher in the HD trees, and its DOP index was sufficient, while the K concentration was low and deficient level in LD trees. Moreover, DOP indices for Ca, Mn, and Zn were less deficient in LD trees than in HD trees, and overall nutrient imbalances were exacerbated in HD trees. RED was significantly lower than RES for N, P, S, Cu, Fe, and Zn but significantly higher than RES for K. The study underscores the significant influence of MTTD on the mineral nutrition of KP mangoes, revealing distinct nutrient variations between trees with low and high MTTD infection levels. These findings have important implications for mango crop management, emphasizing the need for targeted nutrient interventions to address imbalances induced by MTTD and enhance the overall health and resistance of mango trees against MTTD infection.
The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity
Authors: Jain Sidharth S. , Burton Sojo Giselle , Sun Harry , Friedland Benjamin N. , McNamara Megan E. , Schmidt Marcel O. , Wellstein Anton
Published: May 2024

Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evaluated. In this review, we evaluate the impact of cellular senescence in various biological compartments, including the tumor, the tumor microenvironment, and the immune system on immune checkpoint inhibitor efficacy and toxicity. We provide an overview of the impact of cellular senescence in normal and pathological contexts and examine recent studies that have connected aging and cellular senescence to immune checkpoint inhibitor treatment in both the pre-clinical and clinical contexts. Overall, senescence plays a multi-faceted, context-specific role, and has been shown to modulate immune-related adverse event incidence as well as immune checkpoint inhibitor response.
System Design and Launch of Hybrid Rocket with a Star-Fractal Swirl Fuel Grain Toward an Altitude of 15 km
Authors: Takano Atsushi , Yoshino Keita , Fukushima Yuki , Kitamura Ryuta , Funami Yuki , Takahashi Kenichi , Takahashi Akiyo , Kunihiro Yoshihiko , Miyake Makoto , Masai Takuma , Uemura Shizuo
Published: May 2024

To achieve low-cost and on-demand launches of micro satellites, the authors have been researching and developing a micro hybrid rocket since 2014. In 2018, a ballistic launch experiment was performed using the developed hybrid rocket, where it reached an altitude of about 6.2 km. The rocket engine had a 3D-printed solid fuel grain made of acrylonitrile butadiene styrene (ABS) resin in combination with a nitrous-oxide oxidizer. The fuel grain port had a star-fractal swirl geometry in order to increase the surface area of the port, to promote the laminar-turbulent transition by increasing the friction resistance, and to give a swirling velocity component to the oxidizer flow. This overcame the hybrid rocket’s drawback of low fuel regression rate; i.e., it achieved a higher fuel-gas generation rate compared with a classical port geometry. In 2021, the hybrid rocket engine was scaled up and its total impulse was increased to over 50 kNs for reaching an altitude of 15 km. In addition to the engine, other components were also improved, such as through incorporation of lightweight structures, low-shock separation devices, a high-reliability telemetry device and data logger, while keeping costs low. The rocket was launched and reached an altitude of about 10.1 km, which broke the previous Japanese altitude record of 8.3 km for hybrid rockets. The presentation will report on the developed components from the viewpoint of system design and the results of the ballistic launch experiments.
Research of Stroke Patient Occurence Associate with Meteorological Factors in Guizhou Mountain Area
Authors: Guo Xi , Che PingXiao , Zhao XiFou , Mu ChaoShi , Hu DongYuan , Liu QiangGuo , Wang Juan , Wang Biao , Liao TingTing , Yang HengYuan , Wang Hua , Zhi JingYa
Published: May 2024

As previous study in many countries shown that stroke patient onsets are not distributed randomly, but associate with meteorological factors. However, the relationship between stroke occurence and meteorological factors remain unknown in mountain area in Guizhou China. This paper firstly introduces multi-source fusion data which is integrated by the mountain meteorological factor, geographic mapping elevation information data and stroke population monitoring of Guizhou province. Mainly elaborates from a few aspects, which concludes data collection, data sorting, data extraction, data cleaning and data production in detail. A completed and detailed meteorological stroke data set was successfully established and multi-source data fusion was realized by the use of Gbase and unified data service interface of Guizhou meteorological big data cloud platform. And we report the impact of meteorological variables in Guizhou mountain area climate on stroke. In this study, we performed a statistical fusion data between January 2017 and December 2020 about stroke incidence rate and meteorological factors respectively, for instance, concerning the mean (Mean), maximum (Max), minimum (Min), median (Median), standard deviation (Std) . We calculated stroke rates (date stroke occurence)/(year stroke occurence) and we investigated the distribution of days included in the label. Results: the distribution of the incidence rate basically conforms to the normal distribution with the label Max 0.007399, label Min 0.000204, label Mean 0.002738, label Median 0.002643, label Std 0.00076. We observed a positive significant correlation of stroke incidence rate directly proportional to the daily temperature difference (between 0 and 20 degrees Celsius), as the value of this factor exhibits variation larger, the incidence rate is gradually increasing. And we investigated from the Pearson correlation coefficients that stroke incidence increasing when meteorological factors at low humidity (less than 40% (RH 80%), temperature higher than 31℃); the 24-hour daily temperature difference varies between 6 and 10℃ (6
Colistin: Lights and Shadows of an Older Antibiotic
Authors: Diani Erica , Bianco Gabriele , Gatti Milo , Gibellini Davide , Gaibani Paolo
Published: May 2024

The emergence of antimicrobial resistance have represented a serious threats for public health and infections due to multidrug-resistant (MDR) microorganisms represent one of the most important causes of death worldwide. The renew of old antimicrobials, such as colistin, have been proposed as valuable therapeutic alternative to the emergence of the MDR microorganisms. Although colistin is well known to presents several adverse toxic effect, its usage in clinical practice have been reconsidered due to the broad spectrum of activity to gram-negative (GN) bacteria and to the important role of “last resort” agent against MDR-GN. Despite the revolutionary prospective of treatment of this old antimicrobial molecule, many questions remain open regarding the emergence of novel phenotypic traits of resistance and the optimal usage of the colistin in clinical practice. In the last years, several forward steps have been done in the understanding of resistance determinants, clinical usage and pharmacological dosage of this molecule, however, different points regarding the role of colistin in clinical practice and the optimal pharmacokinetic/pharmacodynamic targets are not well defined yet. In this review, we summarize the mode of action, the emerging resistance determinants and its optimal administration in the treatment of difficult-to-treat infections due to MDR Gram-negative bacteria.
Preliminary Insights on the Habitat Use and Vertical Movements of Pelagic Stingray (Pteroplatytrygon violacea) in the Western Mediterranean Sea
Authors: Poisson François , Ellis Jim R. , McCully Phillips Sophy R.
Published: May 2024

Pelagic stingray (Pteroplatytrygon violacea) is the only species of stingray (Dasyatidae) that utilizes both pelagic and demersal habitats. It is the main bycatch species in pelagic longline fisheries targeting bluefin tuna in the Gulf of Lions. In the Mediterranean Sea, their stock structure, behavioural ecology and movements are unknown. For the first time in the Mediterranean, 17 individuals (39 to 60 cm disc width) were tagged with pop-up satellite archival transmitting tags using a novel method of tag attachment, to investigate horizontal and vertical movements. The tags were attached for between two and 60 days. Between the months of July and October, pelagic stingray occupied a temperature range of 12.5 to 26.6°C, and a depth range extending from the surface to 480 m. Monthly trends in catch-per-unit-effort (CPUE) of pelagic stingray peaked in August and decreased by late autumn. Pelagic stingray may aggregate on the continental shelf during summer, and move southwards in early autumn, and this movement pattern is considered in relation to the reproductive cycle and overwintering. Future work and options for bycatch mitigation are discussed.
Identifying Interest Rates Transmission Mechanism under a Bayesian Network
Authors: Chun Byoung Jo
Published: May 2024

This study examines the causal relationships between interest rates in the Korean financial market using a vector error correction model (VECM) and a Bayesian network. The Bayesian network, a novel approach in this context, identifies two distinct transmission channels: one led by call rates (reflecting monetary policy) and another by 10-year Treasury bond yields (reflecting fiscal policy). While the call rate channel aligns with traditional views, affecting bank lending rates, corporate bond spreads, and commercial paper rates, the 10-year Treasury yield channel highlights a separate fiscal policy transmission mechanism, influencing commercial paper rates indirectly through 30-year Treasury yields and directly impacting merchant bank lending rates. This finding suggests that fiscal intervention could potentially interfere with monetary policy, emphasizing the need for coordinated macroeconomic policy measures. The study also emphasizes the role of 10-year Treasury bonds as a benchmark in the Korean bond market, reflecting medium- to long-term economic outlooks and serving as the underlying asset for various derivatives.