bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPERIMENTAL STUDY OF CURRENT SENSORS OF 0.38 KV VOLTAGE CLASS IN THREE MODES OF OPERATION OF THE ELECTRICAL GRID
Authors:   Kostroma State Agricultural Academy, POPOV DMITRIY , OLIN DMITRIY
Published: April 2023

The operation of existing relay protection devices is based on the measurement of electrical network parameters (voltage, frequency, current) performed using sensors installed in the electrical network. Current sensors are subject to high requirements for output data in various modes of operation of the electrical network. As current sensors in the 0.38 kV electrical grid, the following are widely used: current transformers, transreactor sensors, resistive sensors, Hall effect current sensors. (Research purpose) The research purpose is experimentally studying current sensors of various types used in electrical networks of 0.38 kilovolts. (Materials and methods) Conducted laboratory studies on a prepared laboratory stand of various current sensors in three operating modes: steady-state mode, switching mode with initial magnetic flux, switching mode without initial magnetic flux. (Results and discussion) It has been shown that not all types of current sensors can be used as a source of reference data in the construction of high-speed current protection. It was determined that transformer-type sensors can introduce a significant error in the operation of relay protection for reasons of significant angular error, pronounced processes of magnetization and enticement in switching modes. It was found that sensors based on the types of transreactor and Hall effect have the lowest angular error and resistance to switching modes. (Conclusions) It was revealed that when choosing current sensors as a source of reference data, not only passport characteristics, but also laboratory studies should be taken into account. The necessity of taking into account the operational operating time and inductance of the current sensor, the angular error and the shape of the current curve of the secondary circuit was stated.
INVESTIGATION OF THE OPERATION OF ELECTRICAL EQUIPMENT FOR FEEDING PLANTS WITH CARBON DIOXIDE IN PROTECTED SOIL
Authors:   Udmurt State Agricultural University, VLADYKIN IVAN , IVANOV MAKSIM
Published: April 2023

Carbon dioxide, along with nutrients, light and water, serves as one of the most important factors for growing plants. But the carbon dioxide contained in the atmosphere may not be enough. In modern crop production, they are increasingly inclined to use additional equipment, with the help of which the CO2 fertilization of plants is carried out. At the same time, control over the processes of vegetation and flowering (fruiting) improves. (Research purpose) The research purpose is creating an experimental setup and conduct experiments. Determine the external parameters that affect the maintenance of the required CO2 level. Find ways to control the concentration of carbon dioxide, independent of external conditions. (Materials and methods) Analyzed domestic and foreign literature, based on their own works on this topic, conducted experiments. An experimental installation for spraying carbon dioxide in a volume simulating the construction of protected soil was installed. (Results and discussion) We performed 4 measurements with a time difference of 2 hours. It was shown that the experimental setup based on the compiled algorithm levels the influence of external factors and keeps the set value of CO2 (600 ppm). Readings were taken from sensors located in the area of carbon dioxide cloud spraying, adjustments were made by affecting the operation of electric nozzles. (Conclusions) It was found that it is possible to solve the problem of lack of carbon dioxide when growing plants in the construction of protected soil. For this purpose, it was proposed to use carbon dioxide supply units directly to plants, capable of taking into account and correcting the movement of gas in the construction of protected soil. The results of the experiments carried out on the operation of electrical equipment for feeding plants of protected soil with CO2 were presented.
Cubos
Authors: Marta Silva
Published: April 2023

Cubos is a unique and modern font that combines elements of both Grotesque and Geometric sans serif typefaces. The result is a font that is both quirky and bold. The font features strong, straight lines combined with curves that give it a friendly feel. Cubos is an impactful font created as a response to the first brief of the Type Design subject of the Masters In Graphic Design and Editorial Projects of the University of Fine Arts of Porto.
Non-Transferrin-Bound Iron (NTBI) is an overlooked risk factor for iron poisoning and H63D Syndrome Type-1 in patients with chronically elevated transferrin saturation
Authors: Diamandis Dr. Carolina , rocha fabio , Honda Riku
Published: April 2023

We urge the medical community to recognize the drastic limitations of
conventional diagnostic techniques in detecting chronic NTBI poisoning
and to adopt a much more proactive approach in identifying and managing
patients with elevated transferrin saturation in combination with
relatively low ferritin.
Urosymphyseal fistula after pelvic radiotherapy in a tertial referral centre – a rare entity with significant comorbidity requiring multidisciplinary management
Authors: Brändstedt Johan , Abrahamsson Johan , Baseckas Gediminas , Bobjer Johannes , Gerdtsson Axel , Gunnlaugsson Adalstein , Kollberg Petter , Lydrup Marie-Louise , Nyberg Martin , Wenger Daniel , Sörenby Anne , Tham Johan , Warnolf Åsa , Liedberg Fredrik
Published: April 2023

Objective: To report population-based clinical presentation and outcomes in patients with urosymphyseal fistula (USF) after pelvic radiotherapy (RT).Patients and methods: A retrospective chart review was performed in 33 consecutive patients diagnosed with suspicion of USF in a tertial referral center from 2014–2022 to ascertain information about diagnostic delay, clinical presentation, precipitating causes, treatments received and outcomes during the median 22 months follow-up. Out of 33 consecutive patients with suspicion of USF, one female with vesicovaginal fistula, one patient developing RT-associated bladder angiosarcoma, four patients with short follow-up (<3 months), and three patients that during chart review not were considered to have a USF were excluded. Results: In all, 24 males with a median age of 77 years were diagnosed with USF. Local pain was the predominating symptom in 17/24 (71%) patients. Endourologic manipulations preceded the diagnosis of USF in 16 patients. Five patients had a diagnostic delay of more than 3 months. At diagnosis, 20/24 patients had radiological signs of osteomyelitis, and five had a concomitant rectourethral fistula. Due to comorbidity, five patients were not amenable to any other interventions than urinary catheter or suprapubic tube in conjunction with long-term antibiotics, of which three died from infections related to the USF. Out of the remaining 19 patients receiving some form of urinary diversion, five had recurrent osteomyelitis, of which four did not undergo cystectomy in conjunction with surgery for the USF.Conclusions: Urethral endourologic interventions in patients previously subjected to pelvic RT should be performed cautiously.
Preliminary Antecedents on the Selected Temperature (Tsel) of Rhinella dpinulosa Wiegmann 1834 (Anura: Bufonidae) from the Andean Environments of Chile
Authors: Riquelme Nicza Fernanda Alveal
Published: April 2023

The ambient temperature is a decisive factor in many activities of poikilothermic organisms, since it influences the correct development of their vital processes, which implies the existence of an optimal temperature range. The present study describes selected temperatures (Tsel) of R. spinulosa in adult individuals. For this purpose, adults of this species were acclimatized at 10°C and then subjected to a thermal gradient was used in the laboratory. The mean Tsel in the studied individuals was 23.38±2.65°C, with a range from 17.73°C to 28.93°C. Future surveys are suggested to determine the habitat thermal quality and thermoregulatory precision.
History of the Study of Avian Haemosporidian Parasites in A Neotropical Country: Venezuela
Authors: Silva-Iturriza Adriana
Published: April 2023

Venezuela has a remarkable presence of endemic birds from the Neotropical region. Therefore, the study of avian haemosporidian parasites (Plasmodium, Haemoproteus, Leucocytozoon) in Venezuela should be a priority task for conservation projects, as well as for understanding adaptive processes of the parasite-host-vector triad. The objective of this mini-review is to rescue the most relevant contributions of the study of these parasites in Venezuela and the potentialities derived from them. The greatest contribution reported so far comes from a series of parasitological diagnoses in birds carried out from 1972 to 1990. From these studies, a blood smear collection of wild and captive birds infected with haemosporidian parasites was created (approximately 23000 blood smear), describing 15 species of these parasites. This extensive collection of blood smears could be used as source material to answer many questions, such as the large-scale spatiotemporal distribution patterns of avian haemosporidian parasites in Venezuela.
Study of Fauna and Public Perception of Captive Animals at Peshawar Zoo, Khyber Pakhtunkhwa Pakistan
Authors: Syed Daud Kamal
Published: April 2023

Zoos are commonly regarded as the best place for amusement and enjoyment. A large number of people vigor to zoos to see different animals with family and friends. The current study investigated "fauna and public opinion of caged animals at Peshawar Zoo" using a well-designed Questionnaire. Questionnaires include questions regarding the zoo environment, public behavior toward animals, and the zoo's involvement in the conservation of endangered species, animal health and enclosure upkeep, and visitor services such as drinking water, a café, and washrooms. People were also polled to choose which species they preferred and which animals they would want to see at the Peshawar Zoo. The responders were then asked whether they had any thoughts or recommendations for zoo upgrades. 198 visitors were questioned both inside and outside the zoo. As a result, it is apparent that the Peshawar Zoo is an excellent location for leisure and recreation. Visitors were excited to view the various animals and were pleased with the zoo's administration. It is specious that the majority of visitors were unaware of the zoo's role in the conservation of endangered animals. A variety of valuable suggestions can aid in the development of the Peshawar Zoo. The concerned authorities should take notes on the methods of education and modes of information used by the zoo management.
Immunocontraceptive Potential of Goat Zona pellucida as Monkey Population Control
Authors: Mustofa Imam
Published: April 2023

A series of studies have explored the immunocontraceptive potential of zona pellucida-3 in local Indonesian goats. Goat zona pellucida-3 (gZP3) proteins have been identified and isolated. It has 82 kDa molecular weight and comprises 63.47% of the total goat zona pellucida protein. Immunofluorescence staining showed that gZP3 protein recognized goat sperm plasma membrane, whereas gZP3 antibodies recognized goat zona pellucida in native smear. In vitro fertilization study showed that gZP3 protein-supplemented in sperm capacitation medium and gZP3 antibody supplemented in oocyte maturation medium inhibited fertilization. It could be concluded that gZP3 was a fertilization receptor in a goat. Elisa and dot blot analysis showed that gZP3 protein was recognized by the serum of fertile unpregnant female mice. Therefore, it could be hypothesized that the gZP3 protein might be immunocontraceptive in mice. Immunization of mice with gZP3 proved that gZP3 prevented pregnancy and was dose-dependent. The contraceptive action of gZP3 was reversible after 14 estrous cycles. In vitro fertilization technique, it was proved that the antibody of gZP3 was able to prevent fertilization and decrease sperm binding rate on mice ova. The gZP3 nucleotide sequence has a homology at nearly 50% of the monkey ZP3 sequence (Macaca sp) but is foreign phylogenetically. The gZP3 protein has the potential to be developed as an immunocontraceptive substance for overpopulated monkeys to prevent agriculture disturbance in areas near forestry.
Effect of Supplementation of Indigofera Shoot Flour on Egg Quality of ISA Brown Layers
Authors: Telleng Malcky Makanaung
Published: April 2023

This study purposed to investigate the effect of using shoot flour of Indigofera zollingeriana from coconut plantations which was added to the ration on the quality of chicken eggs. This research used a completely randomized design with four (4) treatments and five (5) replications. The experimental ration contain Indigofera shoot leaf flour (ISLF) which was tested consisted of: P0 = 0% ISLF, P1 = 2.5% ISLF, P2 = 5.0% ISLF, and P3 = 7.5% ISLF. The variables measured and observed included egg weight, egg shell weight, shell thickness, egg height, albumen height, albumen weight, egg yolk color and egg yolk weight. The research data were analyzed by using Analysis of Variance (ANOVA) based on Completely Randomized Design in using Minitab 16 software. If the treatment has a significant effect, further testing would be carried out with the Honesty Significant Difference Test. This study found that the internal and external quality of eggs was affected when shoot leaf flour from indigofera zollingeriana was added to chicken rations. It was reasoned that organization of indigofera shoot flour to a degree of 5.0% gave the best.
Otel İşletmelerinde Yenilikçi İş Davranışlarının Örgütsel Destek, Yönetici Desteği ve Çalışma Arkadaşı Desteği Üzerine Etkileri: İstanbul İli Örneği
Authors: Tuna Arslan Pelin , Aydın Ekrem
Published: April 2023

Bu çalışmanın amacı otel işletmelerinde örgütsel destek, yönetici desteği ve çalışma arkadaşları desteğinin yenilikçi iş davranışı üzerindeki etkisini araştırmaktır. Bu amaçla İstanbul’daki 4 ve 5 yıldızlı otellerde çalışan 265 kişiden kolayda anket tekniği ile veriler toplanmıştır. Toplanan veriler Doğrulayıcı Faktör analizi ve Yapısal Eşitlik Modellemesi ile test edilmiştir. Araştırma bulguları, örgütsel desteğin, yönetici desteğinin ve çalışma arkadaşları desteğinin çalışanların bireysel yenilikçilik düzeyi üzerinde olumlu etkisi olduğunu göstermektedir. Bu çalışma üç teorik yaklaşımı bir araya getirerek (örgütsel destek, yönetici desteği ve çalışma arkadaşları desteği) hem turizm literatürüne katkı sağlamakta hem de otel işletmeleri yöneticilerine bireysel yenilikçiliği geliştirmede izlenecek stratejik yaklaşımın nasıl olması gerektiği yönünde yol göstermektedir.
Le discernement pastoral et l’économie ecclésiale dans les communautés locales d’après les documents du Concile in Trullo
Authors:   Babeș-Bolyai University, Vlaicu Patriciu
Published: April 2023

The general topic of the analysis of the author aims to observe several facets of the manifestation of pastoral work in local communities. To highlight this, the author considers it very important to understand how the Church implements her canonical decisions so that the faithful are supported in their spiritual life according to a good management of the means available to the Church (oikonomia) and by showing pastoral discernment both at the personal and community level. In order to achieve this goal, the author analyses the way in which these two notions are present in the documents promulgated by the Council of Trullo (691-692). e whole pastoral ministry of the Church is a manifestation of ecclesial discernment. e canons of the Council in Trullo are fundamental texts of the Church which bring together the entire canonical tradition highlighting the relationship between the pastoral discernment of the servants of Christ and the freedom of those who seek spiritual healing. An important role is given to Canon 102 of the Council of Trullo.
“Resurrection” in the Dying Villages: The Case of Serbia
Authors:   University of Belgrade, Jović Rastko
Published: April 2023

In this paper, the author has attempted to present the relationship between the Orthodox Church and rural areas in Serbia, primarily in the 19th/20th century. Rural areas have always posed many issues to the Orthodox Church, playing different roles in the paradigm of the Church mission. Although the Serbian Church accepted the village as an essential defender of Christianity, church leaders did not put enough efforts into educating and Christianizing these areas. Today, with the new currents in Serbian society, these parishes are dying out. In the light of these changes, we propose, at the end of this article, possible missionary guidelines for the Church in rural Serbian society for the 21st century. At the end of the article the author gives a proposal as to what the Church could reasonably hope to achieve in today’s Serbian village in terms of the issues of: hopelessness–post-EU hope, progress of relationships, liturgical life, “theological aristocracy”, human dignity, and villages instead of old people’s homes.
Models of Exercise of Pastoral Care in Parishes according to the Canon Law of the Catholic Church
Authors:   University of Fribourg, Kaptijn Astrid
Published: April 2023

The author of the paper starts by describing the most fundamental elements of a parish, by emphasizing the fact that during the last decades the Catholic Church, especially in the West, has had to face the question of how to organise the pastoral care of the faithful with a decreasing number of priests. This is not just a mathematical question concerning the appropriateness of the ratio of the number of parishes to the number of priests. The author emphasizes the fact that there are also some principles that the Catholic Church tries to maintain. Some of them are formulated in the documents of the Second Vatican Council and have been integrated into the Canon Law of the Catholic Church. The norms of canon law have two dimensions. They are structured in an Eastern part, with the Code of Canons of the Eastern Churches, promulgated in 1990 and applying to the Eastern Catholic Churches, and in a Western part, contained in the Code of Canon Law of 1983 which is in force for the Latin Church. When it comes to basic principles in the field of pastoral care, both Codes are pretty similar. Apart from them, some other documents have been published by the Holy See. We will refer to these in due course. The present study will treat successively two questions. First, that of the principles according to which pastoral care should be provided. Secondly, the question of the different models envisaged by both Codes.
Caracterización físico-química y microbiológica del agua de un municipio del departamento de Boyacá, Colombia
Authors: Dorado-González Liliana , Dueñas-Celis Mery , Suescún-Carrero Sandra Helena
Published: April 2023

Introducción. El agua salubre y fácilmente accesible es importante para la salud pública, si se utiliza para beber, uso doméstico, producir alimentos o fines recreativos. El agua contaminada y el saneamiento deficiente están relacionados con la transmisión de enfermedades.
Objetivo. Evaluar las características físico químicas y microbiológicas de la red de distribución del acueducto urbano de un municipio de Boyacá.
Materiales y métodos. Estudio cuantitativo descriptivo transversal, se realizó la toma de muestras de agua en 13 puntos, siete concertados y materializados de la red de distribución, uno en la bocatoma de entrada de la planta, dos pozos y en tres nacimientos, de donde se abastece la población. Se realizaron análisis físicos, químicos y microbiológicos de cada una de las muestras.
Resultados. Las muestras sin tratamiento presentaron niveles altos de unidades platino cobalto y turbiedad. El cloro residual libre en dos muestras de agua tratada estaba por debajo de los límites establecidos. Se detectaron microorganismos heterótrofos y Coliformes en las muestras de agua obtenidas de fuentes de abastecimiento. En dos puntos se encontró quistes de Giardia y ooquistes de Cryptosporidium.  De las 13 muestras estudiadas, tres arrojaron un Índice de Riesgo por calidad del agua inviable sanitariamente.
Conclusiones. Se evidencia que el agua se encuentra en un nivel de riesgo inviable sanitariamente, lo cual demuestra que el sistema de tratamiento no es suficiente para garantizar el suministro de agua apta para el consumo humano.
Estrategias para evaluación de extractos de polifenoles en modelos in vitro de cáncer de vías digestivas
Authors: Ferrebuz-Cardozo Atilio Junior , Sánchez-Quitian Zilpa Adriana , Márquez-Salcedo Ruby Alba Elizabeth , Carreño-Saltarén Lady Johanna
Published: April 2023

Introducción: Los polifenoles son compuestos que se encuentran naturalmente en los alimentos como frutas, verduras, té, vino y chocolates, se le atribuye beneficios a la salud humana por su capacidad antioxidante, entre otras. El cáncer las vías digestivas se encuentran entre la tercera y quinta causa de muerte para la población, aumentando el interés por realizar los estudios dirigidos a encontrar compuestos polifenólicos que ayuden en su prevención o tratamiento. Objetivo: identificar las estrategias disponibles para la evaluación de polifenoles en células de cáncer de vías digestivas. Metodología: Se realizó una búsqueda de literatura en bases de datos como Ovid, Pubmed, Science Direct y Elsevier Journal y se seleccionaron artículos donde se reporta el efecto biológico de los polifenoles sobre líneas celulares de cáncer de vías digestivas publicados entre el 2012 y 2022. Resultados: Actualmente estudios reportan el uso de un buen número de líneas celulares como modelos in vitro para estudios de polifenoles en cáncer resaltando las líneas AGS y HT-29, además de técnicas para la caracterización de los polifenoles como el ensayo 2,2-Difenil-I-Picril Hidrazilo (DPPH), sin embargo, para evaluar el efecto biológico se identifican diversas pruebas que deben ser analizadas antes de su implementación. Conclusiones: En la literatura se identifica que existen varias alternativas y estrategias para la evaluación de extractos vegetales en cultivos in vitro de cáncer de vías digestivas, no obstante, antes de pasar al diseño experimental deben tenerse en cuenta una serie de consideraciones para garantizar la utilidad de los resultados.
La evolución del concepto de lo dionisíaco en el pensamiento de Nietzsche
Authors: Ruiz Sanjuán César
Published: April 2023

Lo dionisíaco constituye uno de los conceptos fundamentales del pensamiento de Nietzsche, presentándose en diversas configuraciones en diferentes etapas de su filosofía. Para comprender esta evolución, resulta esencial determinar con precisión la génesis de este concepto. Para ello, comenzamos analizando la relación en la que se encuentra lo dionisíaco con la filosofía de Schopenhauer. A continuación, abordamos el sentido que tiene lo dionisíaco en el libro en que se presenta por primera vez, El nacimiento de la tragedia. Finalmente, nos ocupamos de la transformación que experimenta el concepto de dionisíaco en la obra de madurez de Nietzsche.
En busca de la verdad perdida
Authors: Carrascosa Gil Andrés
Published: April 2023

Este trabajo establece un diálogo acerca del concepto de verdad según el pensamiento de Leonardo Polo y tres pensadores contemporáneos. En primer lugar, se realizará un análisis del planteamiento del pensador francés Michel Foucault a través de su obra “Vigilar y castigar: nacimiento de la prisión”. En segundo lugar, se describirán los principales puntos de confluencia con la obra “La fe de los demonios (o el ateísmo superado)” del filósofo francés Fabrice Hadjadj. En tercer lugar, se analizará la obra “Las doce reglas: un antídoto al caos” del psicólogo canadiense Jordan Bernt Peterson.
Inserción laboral de los egresados de la Universidad de Málaga del curso académico 2017-2018 a los tres años de egresar
Authors: Peñafiel Velasco Antonio , Ventura Fernández Rafael , Abad Guerrero Isabel María , Doblas Navarro Sonia , Núñez Lupiáñez Raquel , Andrade García Carmen María
Published: April 2023

El objetivo del presente estudio es conocer la situación laboral de los egresados de la Universidad de Málaga, a los tres años de finalizar sus estudios. Se proporcionan los principales indicadores de inserción, la satisfacción global con el empleo, así como el análisis de las competencias y las características demandadas en el mercado laboral, entre otras. Este informe general se acompaña de otros desagregados por nivel de estudios y ramas de conocimiento, realizados por el Observatorio de Empleo de la Universidad de Málaga, unidad que pertenece al Vicerrectorado de Innovación Social y Emprendimiento. El objetivo es que los datos y análisis ofrecidos en esta publicación se conviertan en una ayuda valiosa para la comunidad universitaria, para los agentes implicados en los procesos de orientación profesional universitaria y ayude en la toma de decisiones al futuro y actual estudiantado, y a egresados y egresadas. La población objeto del estudio es la promoción 2017-2018, que comprende un total de 6.507 egresados, de los cuales 4.988 son de Grado, 1.438 de Máster y 81 de Doctorado.
Informe GUESSS UMA 2021 : El espíritu emprendedor de los estudiantes universitarios
Authors: Ventura Fernández Rafael , Abad-Guerero Isabel María , Martínez-Martínez Sofía Louise , Muñiz Fernández Ana , Nadales Luque Marina , Andrade García Carmen María
Published: April 2023

El Proyecto GUESSS (Global University Entrepreneurial Spirit Students' Survey) nace en 2003 con el objetivo principal de estudiar las intenciones emprendedoras de los estudiantes universitarios a nivel mundial. La iniciativa es concebida como un observatorio de investigación de naturaleza colaborativa liderado desde su inicio por la Universidad de Saint Gallen (Suiza). La metodología utilizada en el Proyecto GUESSS es común a en todos los países y se replica con una periodicidad de dos años. En esta edición, el proyecto ha sido liderado a nivel mundial por el profesor Philipo Sieger (GUESSS CEO) y Lea Raern (GUESSS Assistant) de la Universidad de Berna, y los miembros del comité de supervisión, los profesores de la Universidad de St. Gallen Thomas Zelweger, Urs Fueglistaller e Isabel Hatak. En España, el proyecto GUESSS España (https://guesss-spain.com/) se coordina desde la estructura del Observatorio del Emprendimiento de España. El trabajo de campo y la coordinación de la participación de las universidades españolas ha sido dirigido por el profesor José Ruiz Navarro y un equipo de investigadores de la Universidad de Cádiz.
Synthesis of Pneumatic Systems in the Control of the Transport Line of Rolling Elements
Authors: Szcześniak Adam , Szcześniak Zbigniew , Cedro Leszek
Published: April 2023

This paper presents the synthesis of a pneumatic control system for a selected configuration of the transport path for the delivery of rolling elements to spiral storage in inter-operational transport. The sequential control system sets the state of the manifolds to ensure a flow of workpieces to serve the subsequent storage. The essential module of the control system is the memory block. It is developed based on a storage filling sequence graph. The filling level of the storages can be monitored in one or two points using sensors. The rolling element displacement control sensors work together with appropriately designed systems to execute the delay of the rising and falling edge input signal. By using a two-level control of the filling level of the storages, it is possible to control the emptying status of the storages as a function of the technological time of removal of the items from the storage between the two control points. Control systems were synthesised and verified using Festo’s FluidSim computer programme.
PEG-liposomal doxorubicin as a potential agent for canine metastatic osteosarcoma – in vitro and ex ovo studies
Authors: Walewska Magdalena , Małek Anna , Taciak Bartosz , Wojtalewicz Anna , Wilk Sylwia , Wojtkowska Agata , Zabielska-Koczywąs Katarzyna , Lechowski Roman
Published: April 2023

Introduction

Appendicular osteosarcoma (OSA) is a highly aggressive and metastatic primary bone tumour in dogs. Standard therapy is amputation and adjuvant chemotherapy (e.g. with doxorubicin). Liposomal drug delivery may augment therapeutic efficacy and reduce negative side effects. Polyethylene glycol (PEG)-liposomal doxorubicin treats human metastatic cancers effectively. The study aimed was to evaluate PEG-liposomal doxorubicin’s inhibitory effect on canine metastatic proliferation and migration in vitro. It also aimed to appraise the drug’s extravasation inhibition in vivo using the human medicine–proven chick embryo chorioallantoic membrane ex ovo model.

Material and Methods

The canine D-17 OSA cell line was cultured and inoculated with decreasing concentrations of PEG-liposomal doxorubicin and conventional doxorubicin in a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test of cell viability, proliferation and cytotoxicity. Flow cytometry with Annexin V and Draq 7 staining confirmed the MTT test results, indicating dead, early and late apoptotic, and live cells. The inhibitory effect of the two preparations on cancer cell migration was investigated with a wound-healing assay. Culture plates seeded with cells were prepared. The cell monolayer was scratched and images of cells migrating to the scratch were captured at 0 h, 12 h and 24 h. Also, embryos were removed from three-day-incubated fertilised chicken eggs. On the 12th day, labelled D-17 cells were injected into each embryo. Embryos in one group received 100 μL of phosphate-buffered saline as controls, those in another group 30 μg/mL of PEG-liposomal doxorubicin, and those in the last group 6 μg/mL of conventional doxorubicin. The effectiveness of the intravascular administration of the D-17 cells was confirmed under a microscope.

Results

PEG-liposomal doxorubicin inhibited the migration of canine OSA cells more effectively than conventional doxorubicin (P ≤ 0.05). The ex ovo model showed that both drugs had similar impacts on canine metastatic OSA.

Conclusion

The liposomal form of the drug may be considered a potentially effective compound in canine metastatic OSA; nevertheless, further in vivo studies are essential to confirm this hypothesis.
Multiple sclerosis relapse after COVID-19 vaccination
Authors: Hefni Tahani , Asiri Nawal , Bokhari Ahmad , Alaboush Ghada , Qashqari Abdulaziz , Almalki Laila
Published: April 2023

Objective: This study aimed to assess the effect of COVID-19 vaccines on multiple sclerosis (MS) patients and associated relapse.
Methods: A retrospective study was conducted among 202 MS patients at King Abdullah Medical Complex, Jeddah, Saudi Arabia. Through phone calls and messages, a questionnaire was used to collect data about patients' demographics, clinical data, data about COVID-19 vaccination, and data about the appearance of MS relapse symptoms after vaccination.
Results: The mean age of patients was 35.11 ± 8.14 years, 79.3% were females and the mean duration since diagnosis was 7.42 ± 5.68 years. Only 7.9% and 2.5% of people were diagnosed with diabetes or vasculitis, respectively, and 89.1% were taking their MS medication. Around 199 (98.5%) received the COVID-19 vaccine, and 10.4% relapsed after receiving the COVID-19 vaccine. Patients who relapsed had a significantly shorter mean duration of taking MS medications and were hospitalized at a significant higher rate. There was no statistically significant relationship between relapse and patients' demographics, clinical data, or vaccine type.
Conclusion: COVID-19 vaccination might cause relapses in some MS patients, but the benefits of vaccination far outweighed the risks. Multicenter studies are needed in the future to confirm the causal relationship.
Emirates Society of Emergency Medicine - ESEM2022 - Abstracts
Authors: Medicine Emirates
Published: April 2023

Abstracts of the Emirates Society of Emergency Medicine Conference 2022 (ESEM22) held from 7 – 10 December 2022 in Abu Dhabi – United Arab Emirates
Transformación de las Fuerzas Militares: clave para el futuro de la seguridad y defensa nacional
Authors: Mejía Ferrero Alberto José
Published: April 2023

Las Fuerzas Militares de Colombia han evolucionado para enfrentar con éxito los retos y desafíos que impone la defensa de la soberanía, la independencia, la integridad del territorio nacional y el orden constitucional. En su preparación para atender las complejidades del presente y las incertidumbres del futuro, adelantan un proceso de transformación que las fortalece por cuanto les garantiza ser capaces de cumplir múltiples misiones al promover una mayor profesionalización de sus hombres y mujeres, una gestión transparente y una modernización eficiente, que permite el desarrollo de capacidades para ofrecer respuestas oportunas, eficaces y sostenibles a los requerimientos estratégicos que surjan del análisis del entorno nacional, regional y mundial.
Fe en Colombia. Un programa de todos y para todos
Authors: Valencia Valencia Mario Augusto
Published: April 2023

El artículo presenta un acercamiento general al programa interinstitucional Fe en Colombia, expresando de manera particular los procesos articuladores que enfocan la integración público privada en un ámbito nacional e internacional, con la participación activa y eminentemente social de las Fuerzas Militares.

El propósito es mostrar, a través de los últimos cincuenta años, la evolución del concepto de Acción Integral, la doctrina y las capacidades instaladas para acompañar la institucionalidad en beneficio de las poblaciones vulnerables. Se hace a través de un análisis histórico de las experiencias y lecciones aprendidas de la relación civil-militar que han facilitado los cambios en las Fuerzas para un mayor acercamiento a la población, y una mejor combinación de seguridad y desarrollo social en las regiones más apartadas. El resultado se da mediante la creación de nuevos espacios de convivencia y construcción de confianza; integrando en toda la geografía nacional, la Fuerza Pública, instituciones del gobierno, organizaciones no gubernamentales y entidades del orden privado.

En conclusión, el programa Fe en Colombia, con una acción conjunta, coordinada e interagencial lleva la presencia estatal a las regiones, planteando líneas estratégicas de desarrollo en infraestructura, vías, bienestar y educación, aumentando la credibilidad de la institucionalidad frente a la población civil.
Los Ejércitos nacionales frente a la guerra híbrida
Authors: Alfonso Carlos Alberto
Published: April 2023

Debido a los cambios en los conflictos bélicos recientes, que de alguna manera han mostrado mutaciones, evoluciones o bien hasta retrocesos en el empleo de los medios militares, es intención de este trabajo brindar una aclaración al marco teórico existente en la clasificación de las guerras, como en sus características, de manera tal que se aborde el concepto de guerra híbrida con una claridad mayor a la que existe actualmente, para luego determinar cuál es la posición en que se encuentran los ejércitos nacionales frente a este fenómeno.
La contranarrativa como estrategia en la lucha contra el terrorismo
Authors: Buitrago Rincón Pedro A.
Published: April 2023

La lucha contra el terrorismo constituye en la actualidad el principal objetivo de los Estados, no solo por la dimensión institucional que busca afectar, entendida como la estabilidad de las nociones de gobernabilidad y gobernanza, sino porque rebasa los mecanismos de presión política que puedan ser aplicados a un Estado, aspecto que obliga a los ciudadanos a lidiar con niveles de violencia injustificados. Y es que siempre que se hable de terrorismo, se tiene que pensar en violencia (Reinares, 2003 ), porque el terrorismo no es otra cosa que el empleo arbitrario e indeterminado de la violencia, pensada como una fuerza injustificada aplicada para esparcir en la sociedad un sentimiento de angustia profunda, pánico y zozobra, a través de la instrumentalización mezquina de blancos indeterminados. Cada vida perdida es una tragedia en sí misma; no obstante, encierra un fenómeno que es aún más monstruoso, el cual implica la transmisión de un mensaje grandilocuente en sí mismo y que ha sido cuidadosamente pensado para contribuir a la construcción y consolidación del ethos de los grupos terroristas, entendiendo el ethos, según lo define Guzmán, como “el espíritu que permea a un grupo social, un conjunto de actitudes y valores, hábitos arraigados en el grupo” (Guzmán, 2007, p. 139).
En consecuencia, una estrategia que se precie de abordar de manera integral el fenómeno escondido tras cada acto de terrorismo, debe partir de la premisa de entenderlo como un fenómeno con implicaciones sistémicas y, en consecuencia, entre otros objetivos, debe querer privarlo de su principal finalidad, esto es, la transmisión de un mensaje y la consolidación de procesos de influencia sociocultural. Allí es precisamente cuando adquiere importancia la generación de procesos de contranarrativa, que desvirtúen los mitos que se han formado en torno a las bondades o glorias derivadas de los ataques indiscriminados del terrorismo.
Ciberseguridad y ciberdefensa: pilares fundamentales de la seguridad y defensa nacional
Authors: Osorio Lalinde Alexander , Lorduy López Gisell , Amaya Henao Lina María , Arenas Méndez Tatiana
Published: April 2023

En las últimas dos décadas los Estados, organizaciones e individuos son altamente dependientes de la información concentrada en la web y de las herramientas tecnológicas. La conectividad brinda la oportunidad de obtener información en tiempo real, y a su vez, infiltrar, modificar, sustraer, manipular o infectar la información, en beneficio propio o de terceros.
Esto ha obligado a los Estados a que, a través de sus instituciones, formulen una estrategia adecuada, moderna y actualizada para enfrentar la ciberguerra, los ciberataques y el ciberterrorismo. El presente artículo abordará el tema de la Seguridad y Defensa nacional, desde la perspectiva tradicional de los conflictos surgidos entre dos Estados, y cómo estos emplean nuevos conceptos de guerra.Actualmente la comunidad internacional atraviesa un momento coyuntural, derivado de varios fenómenos sociales y culturales que han modificado la visión de la guerra, pues esta se ha configurado, a lo largo de la historia, como la expresión más antigua que existe como medio de coerción hacia un grupo de individuos que por lo general no se identifican como iguales. Sin embargo, ¿es la guerra un fenómeno que solo se ejecuta para conseguir poder? ¿Qué es? ¿Se puede afirmar que existe un nuevo escenario global para su posible aplicación?Para dar respuesta a los anteriores interrogantes se abordará en el artículo el cambio de las estrategias tradicionales, que en la actualidad se vienen aplicando en las guerras de cuarta y quinta generación. Las nuevas guerras presentan un sinnúmero de escenarios, que contrastan radicalmente con el concepto tradicional de la naturaleza de las guerras westfaliana y napoleónica, e incluso con aquellas que se dieron a principios del siglo XX. Las nuevas batallas han estado demandando de ejércitos cibernéticos y escenarios intangibles, como lo es el ciberespacio. El cibercrimen, los ciberataques e incluso el clímax del ciberterrorismo aún no han sido plenamente comprendidos.
Science Competence Assessment at Middle School: Teacher's Perception and Practice
Authors: Vy Nguyen Thi Phuong , Lien Vu Phuong , Hung Le Thai
Published: April 2023

Science competence is one of the most vital learning outcomes of  Natural Science subjects in general education. The research presents a guideline to develop assessment criteria/toolkits following the science competence components containing science awareness, science inquiry, and scientific problem-solving. A topic titled "how to classify mixtures and separate the mixture" in natural science six is presented to illustrate the guideline. A deep interview method was applied with thirteen natural science teachers to gather information about teachers' perceptions and practices in teaching and assessing activities to support students in enhancing their science competence. Feedback from teachers about the proposed guidelines was also collected. The research results created a picture of implementing Natural Science subjects in secondary schools with information about the challenges and needs of teachers to improve the issues. This paper is expected to provide teachers have more valuable tools in the innovation phase toward competence-based teaching and assessment.
Chinese Reading Learning Strategies of Vietnamese Students
Authors: Vu Luu Hon
Published: April 2023

The article uses the questionnaire survey method, surveying the use of strategies for learning Chinese reading skills of 187 students majoring in Chinese language at the Ho Chi Minh City University of Foreign Languages - Information Technology. The survey results show that: Students have a high frequency of using strategies for learning reading skills, in which the cognitive strategies and the metacognitive strategies have a high frequency of using them. Socio-affective strategies have moderate frequency of use. There is no difference in the use of reading strategies in terms of demographic factors (gender, region). There exists a positive correlation between the cognitive strategy group and the socio-affective strategies with the students’ reading skills learning outcomes, there is no correlation between the metacognitive strategies and the students’ reading skills learning outcomes. From the above research results, the article made some recommendations in teaching Chinese reading skills to Vietnamese students.
Personal Data Protection Issues in the Realm of Telemedicine. Blockchain, Civil Liability and other Methods to Overcome Them.
Authors: Markov Boris
Published: April 2023

The subject of this article is the legal regulation of personal data protection in the field of medical care with the use of telemedicine technologies and digital healthcare. Its purpose is to identify and analyze the problems of personal data protection and to find ways to overcome them. The relevance of the work is due to the presence of a large number of leaks of personal data, gaps in regulation, and the lack of an effective system of norms aimed at preventing the compromise of patient information. The author examines the main aspects of regulating the procedure for working with the patient's consent to the processing of personal data. Much attention in the article is paid to blockchain technology, traditionally considered in the Russian legal literature only within the framework of the use of cryptocurrencies. The article also analyzes the issues of the application of civil liability measures for offenses in the field of personal data protection of recipients of telemedicine services.The author criticizes the unreasonably strict regulation of the procedure for obtaining the patient's consent to the processing of personal data by a medical organization, emphasizes the need to introduce a flexible form of consent. This will reduce the amount of information at risk of leakage. In addition, the idea of creating a mechanism for revoking the patient's consent to the processing of personal data and securing the patient's right to demand from the medical organization the termination of their processing is put forward. The paper points to the prospects for the use of blockchain in the field of telemedicine, including for the protection of personal data. A regulatory division of blockchain systems into centralized and decentralized ones is proposed, suggesting their different regulation in relation to the protection of confidential information. In addition, the article notes the lack of elaboration of the norms on civil liability for offenses in the field of working with personal data in telemedicine, it is proposed to tighten regulation in order to increase the level of protection of patients' rights.
The vicissitudes of life in the mirror of Nikolai Gumilyov`s literary reputation in the post-symbolist period
Authors: Kuptsova Mariya Yur'evna
Published: April 2023

Nikolai Gumilyov is one of the key figures of acmeism and the literary life of Russia in the 20th century. The image of Nikolai Gumilyov, aspects of his work and influence on literature are of keen interest for modern philology. The article is devoted to a review of the elements of the biography that affect the literary reputation of the poet. The chronological framework of the study is the period from 1910 to 1914, from the period of the decline of symbolism to the outbreak of the First World War. The subject of the study is the reputation of the poet N. Gumilyov in the post-symbolist period. The analysis of the subject is carried out by means of system-typological, biographical and cultural-historical methods. The ups and downs of N. S. Gumilyov's fate influenced not only the creative process, serving as inspiration, but also the literary reputation of the poet, which determines the scientific novelty of the study. The result of the work carried out was the selection, through the analysis of selective places from the biography of N. S. Gumilyov, of such components of his reputation in the period of post-symbolism as “writer”, “traveler” and “lover”. The conclusions presented in the material can serve as a basis for considering both literary reputation in general and directly in the analysis of the image of the poet, as well as in determining the specifics of other periods of Nikolai Gumilyov's work and their influence on the literary reputation of the poet.
Risky eating behaviors in young adults from two communes in the Ñuble region, Chile in the COVID-19 pandemic
Authors: Saéz-Opazo Javiera , Quiroga-Salom Valeria , Torres-Landeros Monserrat , Morales-Ojeda Ismael , López-Espinoza Miguel Ángel , Rojas-Cárdenas Pía
Published: April 2023

Objective: To analyze risky eating behaviors in relation to nutritional status and physical activity in young adults during the COVID-19 pandemic in the communes of Chillán and Chillán Viejo. Methods: Observational and cross-sectional design. A sample of 184 young adults of both sexes, who lived in two communes in the Ñuble region (Chile) during the period of confinement due to the COVID-19 pandemic, was obtained. A personal history questionnaire and the SCOFF scale that assesses the risk of eating behavior disorders (EDs) were applied. Results: A 37.16% risk for ED was found (95% CI: 30.23 – 44.63%). The risk of eating behavior disorders was related to the variables: physical activity (p=0.01 bivariate analysis) and nutritional status (p=0.03, adjusted analysis). Conclusion: It was possible to identify a higher proportion than that recorded in the literature and the factors associated with eating disorders were those that were expected to be found.
Hiperplasia Adrenal Congênita
Authors: Nunes Neto Sérgio Tavares , Bhering Carlos Alberto , Ouriques Nardo da Silva
Published: April 2023

Objetivo: Analisar as características da Hiperplasia Adrenal Congênita (HAC). Revisão bibliográfica: A HAC compreende um grupo de doenças autossômicas recessivas causadas por mutações em um dos genes que codificam enzimas envolvidas na esteroidogênese adrenal. Pode resultar da falha de qualquer uma das enzimas envolvidas na cascata de síntese de hormônios esteróides e a forma mais comum é causada pela deficiência do esteroide 21-hidroxilase (21-OHD), afetando cerca de 1:15.000 nascidos vivos. A discriminação da HAC em formas Clássicas e Não Clássicas é baseada no grau de deficiência da 21-hidroxilase, sendo a HAC clássica subdividida em uma forma perdedora de sal e em uma forma virilizante.  Considerações finais: A HAC é uma doença genética que possui duas formas principais de apresentação. A HAC clássica, mais grave e potencialmente fatal, pode ser diagnosticada através do teste do pezinho no Brasil, o que pode prevenir crises perdedoras de sal que representam o pior prognóstico da doença. A HAC não clássica é geralmente diagnosticada na puberdade ou adolescência. O manejo desta condição é feito através dos glicocorticóides, tendo em vista todas complicações da administração desse medicamento.