bluuebunny/crossref_metadata_2025 huggingface dataset:
A cycle of inflammatory adipocyte death and regeneration in murine adipose tissue
Authors: Admin Ada , Monji Akio , Zhang Yang , Kumar G.V. Naveen , Guillermier Christelle , Kim Soomin , Olenchock Benjamin , Steinhauser Matthew L.
Published: January 2022

Adipose tissue (AT) expands by a combination of two
fundamental cellular mechanisms: hypertrophic growth of existing adipocytes or through
generation of new adipocytes also known as hyperplastic growth. Multiple lines
of evidence suggest a limited capacity for hyperplastic growth of adipose
tissue in adulthood and that adipocyte number is relatively stable even with
fluctuations in AT mass. If adipocyte number is stable in adulthood, despite well-documented
birth and death of adipocytes, then this would suggest that birth may be
coupled to death in a regenerative cycle. To test this hypothesis, we examined
the dynamics of birth of new fat cells in relationship to adipocyte death,
using high fidelity stable isotope tracer methods in C57Bl6 mice. We discovered
birth of new adipocytes at higher frequency in histological proximity to dead
adipocytes. In diet-induced obesity, adipogenesis surged after an adipocyte
death peak beyond 8 weeks of high fat feeding. Through transcriptional analyses
of adipose tissue and fractionated adipocytes, we found that the dominant cell
death signals were inflammasome-related. Pro-inflammatory signals were
particularly evident in hypertrophied adipocytes or with deletion of a
constitutive oxygen sensor and inhibitor of Hypoxia inducible factor (HIF),
Egln1. We leveraged the potential role for the inflammasome in adipocyte death
to test the adipocyte death-birth hypothesis, finding that Caspase 1 loss of
function attenuated adipocyte death and birth in murine visceral adipose
tissue. These data collectively point to a regenerative cycle of adipocyte
death and birth as a driver of adipogenesis in adult murine adipose tissue.
HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial
Authors: Kwan Anita Y.M. , Gerstein Hertzel C. , Basile Jan , Xavier Denis , Maldonado Juan M. , Raha Sohini , Konig Manige
Published: January 2022

Objective:
To evaluate participant characteristics and long-term changes in HbA1c levels
in patients treated with dulaglutide 1.5 mg in a post hoc analysis of the
REWIND trial.

Research Design and Methods: Change from baseline in HbA1c was assessed during and
up to 72 months of treatment before and after adjustment for duration of
diabetes, prior microvascular disease (nephropathy or retinopathy), and BMI.
Slope analyses were used to assess the change in HbA1c during 0-12 months and
12-72 months of therapy.

Results: HbA1c
was significantly reduced in patients treated with dulaglutide compared with
placebo during 72 months of treatment (least-squares mean difference = -0.61%,
P<0.001), regardless of diabetes duration, prior microvascular disease, and
BMI (all interaction P-values >0.07). Significant reductions were apparent
at all timepoints and were independent of these baseline characteristics. Slope
analyses revealed that the dulaglutide group experienced a higher rate of HbA1c
reduction compared with the placebo group from 0 to 12 months before and after
adjustment. The dulaglutide group also experienced a higher rate of HbA1c increase
from 12 to 72 months compared to the placebo group that became non-significant
after adjustment for diabetes duration, prior microvascular disease, and BMI
combined. Despite the greater rate of HbA1c increase in the dulaglutide group
during this period, mean HbA1c values remained below baseline in the
dulaglutide group and below mean HbA1c values in the placebo group.

Conclusions: Dulaglutide
1.5 mg treatment was statistically associated with a long-lasting decrease in HbA1c
over 72 months, irrespective of baseline duration of diabetes, microvascular
disease, and BMI.
Differentiating Microaneurysm Pathophysiology in Diabetic Retinopathy Through Objective Analysis of Capillary Nonperfusion, Inflammation and Pericytes
Authors: An Dong , Tan Bryan , Yu Dao-Yi , Balaratnasingam Chandrakumar
Published: January 2022

Microaneurysms are biomarkers of microvascular
injury in diabetic retinopathy (DR). Impaired
retinal capillary perfusion is a critical pathogenic mechanism in the
development of microvascular abnormalities.
Targeting fundamental molecular disturbances due to capillary
nonperfusion, such as increased vascular endothelial growth factor expression,
does not always reverse the anatomic complications of DR suggesting that other
pathogenic mechanisms independent of perfusion also play a role. We stratify the effects of capillary
nonperfusion, inflammation and pericyte loss on microaneurysm size and leakage
in DR through three-dimensional analysis of 636 microaneurysms using
high-resolution confocal scanning-laser microscopy. Capillary nonperfusion, pericyte loss and
inflammatory cells were found to be independent predictors of microaneurysm size. Nonperfusion alone without pericyte loss or
inflammation was not a significant predictor of microaneurysm leakage. Microaneurysms found in regions without
nonperfusion were significantly smaller than those found in regions with
nonperfusion, and their size was not associated with pericyte loss or
inflammation. In addition, microaneurysm
size was a significant predictor of leakage in regions with nonperfusion
only. This report refines our
understanding of the disparate pathophysiologic mechanisms in DR and provides a
histologic rationale for understanding treatment failure of microvascular
complications in DR.
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
Authors: Admin Ada , Carrasco Manuel , Wang Chencheng , Søviknes Anne M. , Bjørlykke Yngvild , Abadpour Shadab , Paulo Joao A. , Tjora Erling , Njølstad Pål , Ghabayen Jonas , Nermoen Ingrid , Lyssenko Valeriya , Chera Simona , Ghila Luiza M. , Vaudel Marc , Scholz Hanne , Ræder Helge
Published: January 2022

Studies of monogenic diabetes are particularly useful as we can gain
insight into the molecular events of pancreatic β-cell failure. Maturity-onset
diabetes of the young 1 (MODY1) is a monogenic diabetes form, caused by a
mutation in the HNF4A gene. Human induced
pluripotent stem cells (hiPSC) provide an excellent tool for disease modelling
by subsequent directed differentiation toward desired pancreatic islet cells,
but cellular phenotypes in terminally differentiated cells are notoriously
difficult to detect. Re-creating a spatial (3D) environment may facilitate
phenotype detection. In this study, we studied MODY1 using hiPSC-derived
pancreatic β-like patient and isogenic control cell lines in two different 3D
contexts. Using size-adjusted cell aggregates and alginate capsules we showed
that the 3D context was critical to facilitate the detection of
mutation-specific phenotypes. In 3D cell aggregates we identified irregular
cell clusters and lower levels of structural proteins by proteome analysis,
whereas in 3D alginate capsules we identified altered levels of glycolytic
proteins in the glucose sensing apparatus by proteome analysis. Our study
provides novel knowledge on normal and abnormal function of HNF4A paving
the way for translational studies of new drug targets that can be used in
precision diabetes medicine of MODY.
Political Culture in the Baltic States: Between National and European Integration
Authors: Linde Jonas
Published: January 2022

Political Culture in the Baltic States: Between National and European Integration är en gedigen studie av demokratins ställning i de baltiska staterna och den kritiska roll som etniska skiljelinjer kan ha i demokratiseringprocesser. Den har mycket att erbjuda både områdesspecialister och läsare med ett mer allmänt intresse för demokrati och politisk kultur. 
Political Culture in the Baltic States: Between National and European Integration is a thorough study of the situation of democracy in the Baltic states, and the critical role of ethnic cleavages in processes of democratization. It has much to offer to area specialists as well as to readers more generally interested in democracy and political culture.
Pollution and Atmosphere in Post-Soviet Russia: The Arctic and the Environment
Authors: Nilsen Thomas
Published: January 2022

Mens journalister har lett for å ty til adjektiver for å beskrive et økologisk katastrofeområde, er det vanskeligere å se og formidle årsakssammenhenger. Hvorfor fikk ikke sovjetiske, senere russiske, myndigheter i samarbeid med sine nordiske naboland stanset de grenseoverskridende svovelskyene fra østsiden av Pasvikelven? Det er disse spørsmålene Lars Rowe på en systematisk og beundringsverdig godt dokumentert måte gir svar på i boken Pollution and Atmosphere in Post-Soviet Russia: The Arctic and the Environment.  
Journalists easily find adjectives to describe environmental catastrophes; it is more difficult, however, to ascertain and convey their causes. Why, for example, didn’t Soviet, and later Russian, authorities collaborate with Nordic neighbors and manage to put a stop to the sulphur clouds emanating from the eastern side of the Pasvik River? Lars Rowe looks at this question in a systematic and admirably well-documented way and provides answers in his book, Pollution and Atmosphere in Post-Soviet Russia: The Arctic and the Environment.
Evaluación empírica de la calidad de la información: caso de estudio en el sector salud
Authors: López Luna José Fidencio , Herrera Rivas Hiram , Hernández Almazán Jorge Arturo
Published: January 2022

Las instituciones suelen emplear sistemas de información a fin de recabar, procesar, almacenar y obtener información de calidad para la toma de decisiones. Contar con información de calidad es un tema clave para las instituciones. La presente investigación pretende percibir problemas concretos de calidad de información en sistemas de información con el fin de proporcionar una mayor calidad de la información en la prestación de servicios de salud pública. Se diseñó un cuestionario con base en un conjunto de dimensiones de calidad de la información. Posteriormente, se aplicó a 160 usuarios finales de sistemas de información de 10 unidades médicas del estado de Tamaulipas, México. Se han obtenido oportunidades específicas de calidad de información para sistemas de información. Se evidencia la oportunidad de mejora en el tema de calidad de la información en relación con la muestra de sistemas de información considerados en esta investigación. Se sugiere que los resultados obtenidos se consideren en el ámbito académico y profesional a razón de contribuir a elevar la calidad de la información proporcionada por los sistemas de información.
The Impact of ROA, BOPO, FDR, CAR, NPF on Mudharabah Profit Sharing Rate
Authors: Bramandita Bramandita , Harun Harun
Published: January 2022

This research was conducted to analyze the effect of Return on Assets (ROA), Operational Cost of Operating Income (BOPO), Financing Deposit Ratio (FDR), Capital Adequacy Ratio (CAR), and Non-Performing Financing (NPF) on the level of profit-sharing at Mudharabah Banks Syariah with Case Study of BNI Syariah Bank in Indonesia. The data used is using the data recorded in the Financial Services Authority and financial reports published in 2016-2018. The data analysis method that will be used is Ordinary Least Square OLS after a series of Classical Assumptions tests. This research results that were partially finding the independent variables ROA, BOPO, FDR, and CAR have a significant effect. Meanwhile, the NPF variable does not have a significant effect on the Mudharabah Profit Sharing variable. This study shows that the NPF ratio is a picture of non-performing loans that do not significantly affect mudharabah profit-sharing, emphasizing the superiority of sharia contracts, especially mudharabah contracts.
INVESTIGANDO A AUTOAVALIAÇÃO E O ENSINO DE LÍNGUA INGLESA
Authors: Kobayashi Eliana
Published: January 2022

Este artigo traz os resultados do recorte de um amplo estudo qualitativo sobre autoavaliação, autonomia e língua inglesa no ensino médio de uma instituição pública. A concepção de autoavaliação voltada ao desempenho fundamenta esta investigação que apresenta comparações entre as notas de autoavaliação de alunos em uma atividade oral, baseados em critérios discutidos e descritos previamente, e as fornecidas pelo professor da disciplina. Os resultados demonstram ausência de similaridades entre as notas e revelam que alunos com médias elevadas tendem a se autoavaliar com notas mais baixas do que as obtidas, situação oposta à identificada junto aos estudantes com médias menos elevadas.
STUDI KEBUTUHAN NYATA AIR BERSIH PER KAPITA PADA KOTA BANDAR LAMPUNG
Authors: Sinia Ria Oktaviani , Susilo Gatot Eko
Published: January 2022

Sebagaimana telah diketahui bahwa seiring dengan bertambahnya jumlah penduduk, maka jumlah kebutuhan akan air bersih yang harus terpenuhi juga besar. Tujuan dari penelitian ini adalah untuk : (1) menyelidiki besaran jumlah kebutuhan air bersih per kapita di Kota Bandar Lampung; (2) mengidentifikasi faktor-faktor yang berpengaruh terhadap kebutuhan air bersih di Kota Bandar Lampung; (3) menghitung jumlah biaya konsumsi air bersih; (4) Melakukan perbandingan hasil penelitian mengenai besaran kebutuhan air bersih dengan penelitian yang telah dilakukan sebelumnya, baik itu penelitian di negara Indonesia maupun penelitian yang berasal dari negara lain. Penelitian ini mengambil lokasi di wilayah Kota Bandar Lampung yang secara administrasi memiliki 20 kecamatan dan 126 kelurahan. Pengumpulan data kebutuhan air bersih dilakukan dengan penyebaran kuesioner pada 126 rumah tangga secara acak. Berdasar pada hasil penelitian, dapat diambil kesimpulan bahwa: (1) Jumlah kebutuhan air bersih per kapita Kota Bandar Lampung adalah 130,44 ltr/org/hr. (2) Besaran jumlah kebutuhan air bersih pada Kota Bandar Lampung dipengaruhi beberapa hal sebagai berikut, yakni: jumlah anggota keluarga, status pendidikan, jenis pekerjaan, jumlah kepemilikan kendaraan, dan kemudahan mendapatkan air. (3) Biaya yang dibayarkan setiap bulannya untuk pemenuhan kebutuhan air bersih pada Kota Bandar Lampung berkisar antara Rp.127.267,00 sampai dengan Rp.187.449, 00. (4) Hasil yang didapat pada penelitian ini jauh berbeda dengan hasil pada penelitian Kindler and Russel (1984) yang menyatakan  bahwa penggunaan air rata-rata untuk rumah tangga adalah sebesar 295 ltr/org/hr, namun hasil yang didapat pada penelitian ini mendekati Kriteria Perencanaan oleh Direktorat Jenderal Cipta Karya, Dinas Pekerjaan Umum Tahun 1996, yang menyatakan bahwa pada Kota Besar yang memiliki penduduk berkisar antara 500.000 jiwa – 1.000.000 jiwa, kebutuhan air domestiknya adalah 120– 150 ltr/org/hr.
Students’ self-compassion and academic resilience in pandemic era
Authors: Yustika Yustika , Widyasari Pratiwi
Published: January 2022

During the covid-19 pandemic, 12th grade high school students felt more stressed and tired due to a continued isolation. Therefore, academic resilience is needed so that students can face existing academic problems. It was found that self-compassion can foster resilience. This study aims to analyze the relationship between self-compassion using the Indonesian version of the Self-Compassion Scale and Academic Resilience using the Academic Resilience Scale-30. 277 participants from 12th grade high school students who are distance learning took part in this correlational research. Results show that there is a positive correlation between self-compassion and academic resilience. This therefore results in a new finding of how students could be more academically resilient in facing academic burdens during the pandemic. To get a more comprehensive picture, future studies could explore more demographic data, such as whether anyone assists students while distance learning and how stressed students are.
Analisis Abnormal Return Saham pada Peristiwa Merger dan Akuisisi di Indonesia
Authors: Putri Laurenza , Yulita Ima , Wardhani Aurelia
Published: January 2022

This study aims to obtain empirical evidence related to market reactions indicated by abnormal returns around the time of the 2016-2019 merger and acquisition announcement. The population in this study are companies listed on the Indonesia Stock Exchange that have conducted mergers and acquisitions. The sampling technique uses purposive sampling, the data obtained by 12 companies, namely 3 companies do mergers and 9 companies make acquisitions. Data analysis techniques in this study were one sample test method Kolmogorv-Smirnov test, paired sample t-test test, and one sample t-test using SPSS application version 25. The results of this study showed: During the 11 days study period, there were average abnormal return negative that insignificant for 7 days and average abnormal return positive that also insignificant for 4 days around the announcement time of the company’s mergers and acquisitions. These insignificant test results prove that the market was not approved during the period before and after mergers and acquisitions.
Social ideas content transformations under the influence of digitalization
Authors:   Kuzbass State Technical University named after T.F. Gorbachev, Kuzbass State Agricultural Academy, Ravochkin N.N. , Gilyazov R.Sh. ,   Kuzbass State Agricultural Academy, Russia National Research Tomsk State University, Kuznetsov N.V. ,   Kuzbass State Agricultural Academy, Petrov M.A. ,   Siberian Federal University
Published: January 2022

The authors analyze the dynamics of content of ideas that fund social change. The main focus is on the transformation of meanings under the influence of postmodern discourse and digitalization. The ambivalent role of advanced information and communication technologies in the perception, interpretation and understanding of ideas is shown. The increase in the share of fake information that transforms key meanings in intellectual constructs is underlined. The modern experience of the ideological determination of social transformations is considered.
Classification and role of quasi-realities in J.R.R. Tolkien’s literary universe on the epic novel material «The Lord of the Rings»
Authors:   Moscow City University, Rogatova S.V.
Published: January 2022

Quasi-realities in the texts of J.R.R. Tolkien’s works are analyzed. The problem of classifying quasi-realities according to the source of modeling and determining the role of quasi-realities in the creation of artificial literary universes, in order to deeply understand the works of the genre is considered. The influence of the writer’s personality on the quasi-realities he forms is revealed. The proposed classifications make it possible to cover the entire multilevelness of artificially created realities.
The phenomenon of state information sovereignty: analysis of political science discourse
Authors:   National Research University of Electronic Technology, Pirogov А.I. , Ivantsov A.V. ,   Academy of Management under the President of the Republic of Belarus
Published: January 2022

The phenomenon of informational sovereignty of the state is considered, various points of view on its essence and content are provided, its author’s definition is given. It is noted that the concept of information sovereignty is dynamic. The authors state that in modern information space, in the context of globalization, the binding of information sovereignty to territorial boundaries is becoming more and more blurred.
Digital Transformation and Business Adaptation during the lockdown period
Authors:   Moscow University for the Humanities, Mrochko L.V. , Spiridonova G.V. ,   Moscow University for the Humanities, Zhuk A.A. ,   Russian Presidential Academy of National Economy and Public Administration
Published: January 2022

The author considers digitalization trends, which intensified during the pandemic and lockdown periods, in the context of system and corporate governance of the company. Digital technologies, ESG-evaluation of business are attributed to the drivers of norms improvement and changes in the quality of corporate governance. Statistics show the attitude of the board of Russian companies to the digitalization of business. The role of ESG-rating in the sustainability of the company’s business is defined, the assessment of sustainability by the criterion of attitude to the environment and the criterion of openness and accessibility of data are highlighted. The author noted the trend of spreading the ESG-rating principles over the past 20 years in Russia.
Digitalization of the procedure for the provision of social services to the population: innovations and obstacles to their implementation
Authors:   St. Petersburg State Institute of Management, Balashov А.I.
Published: January 2022

The analysis was carried out and the barriers to digitalization of the procedure for the provision of social services in the metropolis were identified based on the analysis of digitalization tools and strategies: the need to constantly improve security systems and methods for storing and processing citizens’ data using cloud technologies, including the development of appropriate strategies and government programs; the need to adapt various digitalization tools to the requirements and capabilities of the local community; difficulty in assessing the demand of social service recipients for certain electronic resources; the need for accompanying training activities for both recipients and providers of social services. It is concluded that when developing a digitalization strategy for the provision of social services to the population of a large urban agglomeration, a universal approach does not always give positive results.
Posthuman ethics
Authors:   National Research University of Electronic Technology, Privalova I.Yu.
Published: January 2022

The content of posthuman ethics is clarified through a comparative analysis of the psychophysical structure of modern man and posthuman, the features of which specifically determine the ethics of different types of society. For this purpose, the content of the concepts mind, consciousness, soul, spirit, human cognition is investigated from the point of view of modern neuroscience, Christian anthropology and Cartesian philosophy. The questions of free will are raised, arguments are given in favor of the concept of compatibilism.
Determination of Zirconium(IV) Based on Flow Injection Analysis with The Xylenol Orange As A Complexing
Authors: Rustiah Waode
Published: January 2022

The development of spectrophotometry method based on Flow Injection Analysis (FIA) to determine Zr(IV) in tin ore accompanying mineral has been done using xylenol orange as complexing agent. The complex between Zr(IV) and xylenol orange 0,05% was formed at pH 2 (1:1). The complex formed having maximum absorbance at wavelength 554 nm. The mineral decomposition has been done by fusion method using Na2CO3 and Na2O2 as fluxs for open system and the close system decomposition using HNO3, HClO4 and HF as solvents. FIA-spectrophotometry that has been developed was able to show good analytical performance, with precision of %KV not more than 5% at concentration level mg/L, was 3,98%, with sensitivity was 2,79 ppm and the detection limits of calculated (S/N = 3) was 0,21 ppm. This method has been aplicated for analyzing Zr(IV) in zircon mineral sample with analysis result 20,26% of ZrO2 and recovery percentage was 100,7%.
Pengaruh Premi, Klaim, dan Hasil Investasi Terhadap Surplus Syariah Underwriting dan Laba Asuransi Syariah Periode 2014-2019
Authors: N A Nur Hikmah , Nofrianto Nofrianto
Published: January 2022

Penelitian ini bertujuan untuk mengetahui premi, klaim, dan hasil investasi terhadap surplus underwriting dan laba pada perusahaan asuransi jiwa syariah di Indonesia periode 2014-2019. Teknik pengumpulan data yang digunakan adalah menggunakan data sekunder yakni data dari laporan keuangan perusahaan asuransi jiwa syariah yang  konsisten dan terdaftar pada Otoritas Jasa Keuangan (OJK) selama tahun 2014-2019. Sampel diambil menggunakan metode purposive sampling dengan jumlah sampel sebanyak 8 perusahaan asuransi jiwa syariah. Adapun metode analisis yang digunakan adalah regresi data panel dan path analysis dengan menggunakan program Eviews 9.0. Hasil penelitian ini menunjukan bahwa premi tidak berpengaruh signifikan terhadap surplus underwriting sedangkan klaim dan hasil investasi berpengaruh signifikan terhadap surplus underwriting. Adapun variabel laba tidak memediasi pengaruh antara premi, klaim dan hasil investasi terhadap surplus hasil underwritting karena diketahui bahwa premi, klaim dan hasil investasi tidak signifikan terhadap laba, dan variabel laba signifikan terhadap surplus hasil underwriting.
Effect of biofertilizer on growth and metaxylem diameter of Amaranthus tricolor L. in salinity stress condition
Authors: Riesty Okky Shavira , Siswanti Dwi Umi
Published: January 2022

Throughout history, agricultural sector in Indonesia has faced a shortage of land. As a result, we must take use of land that is still available, even if the conditions are unsuitable for plant growth, one of which is salinity-stressed land. Amaranth is a frequently cultivated plant in Indonesia (Amaranthus tricolor L.). This vegetable plant is commonly consumed as food due to its nutritional content and numerous health benefits. To cultivate amaranth on salinity-stressed land, additional nutrients are required to ensure that the plants continue to thrive. One of them is the provision of biofertilizers, a type of organic fertilizer that contains beneficial bacteria for plant growth. This study aimed to determinate the effect of biofertilizer application on the growth and diameter of the stem metaxylem of amaranth plants growing in a salinity-stressed environment. As a salinity stress treatment, NaCl was applied at doses of 0, 2500, 5000, 7500, and 10000 ppm. The diameter of the metaxylem was determined by making fresh preparations across amaranth stems. The biofertilizer application does not affect the height and number of leaves of the plant. However, as the dose of biofertilizer was increased, the value of the metaxylem diameter of the stem increased.
Effect of Kombucha Tea on Total Cholesterol Decreasing Levels in White Rats (Rattus norvegicus)
Authors: Halid Zulkifli , Sulaiman Sulaiman , Irhamna Rifka
Published: January 2022

The purpose of this study was to determine the type of content of 75% kombucha tea that is fermented for 12 days,  there are black tea, green tea, and the packaged tea. Fifteen Rattus norvegicus was randomized divided into 5 groups and each group consisted of 3 rats. Group I or the negative control was given aquadest, group II was given kombucha packaged tea, group III was given black tea kombucha, and group IV was given green tea kombucha. Group V as a positive control was given simvastatin. All groups were injected with the samples solution orally. Evaluation of effects was carried out by observed the cholesterol total level before and after treatment. The results showed that all kombucha tea can reduced the total cholesterol level on rats (Rattus norvegicus). Conclusion: Data were analyzed using ANOVA followed by Duncan test with 95% confidence level using SPSS 20.0 software, results showed that black tea kombucha 1.8 mL of 75% concentration has an optimal reduced total cholesterol levels in rats (Rattus norvegicus).
ATR-FTIR Method for Detection of Cassava Impurities in Indonesian Commercial White Pepper (Piper nigrum L.) Based on Principal Component Analysis
Authors: Asnawi Aiyi , Fitriani Ajeng , Febrina Ellin , Emawati Emma
Published: January 2022

White pepper (Piper nigrum L.) is one of the most popular flavourings targeted for adulteration, i.e., cassava, resulting in quality loss and infringement on consumer rights and interests. Because it is easy and quick cleanup, minimal sample preparation, and excellent performance with strongly or thickly absorbed samples, the Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) spectrum signal is widely used to measure commercial herbal products. Manipulation of the spectrum signal can be used to quantify a sample as well as reduce its dimensionality. As a result, there is a lot of interest in developing methods for detecting cassava in commercial white pepper (Piper nigrum L.). The aim of the research was to get an ATR-FTIR spectroscopic technique combined with chemometrics to detect cassava as an adulterant in commercial white pepper (Piper nigrum L.). The chemical profiles of white pepper (Piper nigrum L.) and cassava were compared using principal component analysis (PCA). Bangka, Sudu, and Pontianak were used to collect white pepper (Piper nigrum L.)  and cassava. White pepper (Piper nigrum L.) and cassava were macerated in 96 percent ethanol for 3×24 hours before being concentrated with a rotary evaporator until thick. Each extract's IR spectral was measured using ATR-FTIR spectroscopy in the 4000-650 cm-1range. In addition, the IR spectral was clustered using PCA in the R program. To obtain the appropriate PCA model, we applied two IR spectral manipulation procedures (normal and derivative IR spectra) of the pure material. The PCA chosen was of the normal IR spectral type, with PC1 and PC2 values of 82.3 percent and 7.5 percent, respectively.. The projection of three commercial samples from the markets revealed that samples A and B were negative for cassava adulterant, while Sample C was suspected to be positive. Finally, the ATR-FTIR spectroscopic method tandem PCA was successful in clustering the presence or absence of cassava content in the commercial of Indonesian White Pepper
Histopathological Study of Streptozotocin Induced Liver Regeneration of Wistar Mice after Administration of Pumpkin Leaf Ethanol Extract
Authors: Dewi Niluh Puspita , Kawanga Windi Olivia , Lakiu Debora Rislianti
Published: January 2022

This study aims to prove that the ethanol extract of pumpkin leaf can improve the liver histological structure of Wistar rats streptozotocin and find out the effective dose in regenerating the liver cells of Wistar rats. Wistar rats were divided into six groups so that each group has five replications. The control group was not given the extract, and the treatment group was administered the extract with three doses of 125 mg/kg BW, 150 mg/kg BW, and 175 mg/kg BW which were carried out for three weeks. Rats were then sacrificed and the liver organs were taken for the histopathology preparations with Hematoxylin-Eosin staining (HE). The results showed fatty degeneration and necrosis of the livers. The results of the Mann-Withney test analysis showed that there was a significant difference in liver histopathology scoring from each treatment group. Ethanol extract  of pumpkin leaves at a dose of 150 mg/kg BW gave an effect on the  regeneration of liver cells of Wistar rats with a damage score of 1.4 and had no effective dose
THE DIFFICULTIES IN TEACHING VOCABULARY FACED BY THE ENGLISH TEACHERS AT MTs MADANI PAO-PAO MAKASSAR
Authors: Ardiyanti S Sulasri , Kamsinah Kamsinah , Nurasik Nurasik , Said Abdul Muis
Published: January 2022

This research describes the difficulties in teaching vocabulary by the English teachers faced at MTs Madani Pao-Pao Makassar. It is conducted to know the difficulties in teaching vocabulary by the English teacher and also the factors that caused the difficulties in teaching vocabulary at MTs Madani Pao-Pao Makassar. The researcher uses descriptive qualitative to analyse the data. The researcher collects the data through observation and interview. The data are from the interview script. The researcher conducted the data by the English teachers as the subject. The teachers teaching in class 7 at MTs Madani Pao-Pao Makassar. The methods used by the researcher are collecting the data are conducted observation and interviews. The procedure for collecting data analysis is data reduction, data display, conclusion. Based on the class observation and interview, the researcher concludes the difficulties in teaching vocabulary at MTs Madani Pao-Pao Makassar and what are the factors that caused the difficulties for the teachers in teaching vocabulary at MTs Madani Pao-Pao Makassar. Based on the observation and interview, the researcher concluded that the difficulties in teaching vocabulary by the English teacher are classroom management; the teacher’s difficulties in motivating the students; the teaching media is limited (especially textbooks); teacher’s difficulties telling students for memorizing vocabulary. The factors that caused the difficulties in teaching vocabulary are laziness; lack of motivation; lack of vocabulary; students' lack of pronunciation; and students' lack of confident when learning English. The researcher suggested for the teachers to learn how to overcome their problems in the English especially vocabulary of the students, classroom management, and motivate the students for learning English because those were the main factors that affect teachers' difficulties in teaching vocabulary.
INTEGRATING ISLAMIC VALUES INTO THE DEVELOPMENT OF ANNOUNCEMENT AND NOTICE UNIT FOR THE EIGHTH GRADE IN MTs MADANI PAO-PAO
Authors: Zahra Andi , Asmawati Andi , Kamsinah Kamsinah
Published: January 2022

English material that is used in the school is too general. It is also already not reflecting Islam itself. To maintain students’ identity as Muslim, this paper is aimed to integrate Islamic Values into English material especially in basic competences 3.12 and 4.12 about Announcement and Notice for the eighth-grade students at MTs Madani Pao-Pao based on 2013 curriculum. The research design used in this study was Research and Development (R & D). The development model used was ADDIE   model. It consists of need analysis, design, development, implementation, and evaluation.  The procedures included analyzing materials needed by spreading questionnaire to the students and analyzing the basic competences used, designing a blueprint of materials, and developing the English materials through ADDIE model. In this research, the expert was involved in order to validate the product. There were two systematic aspects the product that they validated: the aspect of the content/material and aspect of learning.  Therefore, the result indicated that based on experts’ judgment as well as product development result, the developed basic competences 3.12 and 4.12 was applicable to be taught at the eighth-grade students of Junior High School as topics in English.
Periodisasi Penciptaan Alam Semesta Dalam Manuskrip Kutika dan Science Islam
Authors: Basir Fathur Rahman , Syarif Muh. Rasywan
Published: January 2022

Peristiwa-peristiwa penciptaan alam semesta telah banyak diteliti oleh para filosof yang berusaha mencari kebenaran melalui dialog antara sains dan agama. Dalam dunia sains Islam, telah banyak menyingkap rahasia-rahasia penciptaan alam semesta yang banyak terkandung dalam Ayat-ayat Al-Quran. Lontraq Kutika adalah salah satu manuskrip kuno yang merupakan kitab Astrologi yang ditulis oleh leluhur Masyarakat suku Bugis-Makassar. Tujuan penelitian ini untuk menambah khazanah keilmuan dengan melahirkan beragam dialog yang saling berafiliasi didasari dari dengan nilai-nilai budaya lokal, bahasa, agama, dan sejarah dengan membawa ciri khas yang memiliki ruang gerak bersifat primordial dan tradisional. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan menggunakan pendekatan historis sosio-antropologis dan  normatif. Hasil penenlitian ini menunjukkan bahwa kemajuan pengetahuan dan kosmologi tidak hanya didasari oleh sains dan agama, tetapi budaya juga turut menafsirkan penciptaan alam semesta seperti yang terkandung dalam manuskrip/lontaraq Kutika yang juga berisi tentang penanggalan hari.Kata kunci: Alam Semesta, Kutika, Sains Islam.
ANALISIS TINGKAT KESIAPAN PEMBELAJARAN DARING DI MASA PANDEMI COVID-19 PADA GURU SMK
Authors: RUKTIARI RIMA , SEPTIANA ASYIFA IMANDA , PIU SRI WAHYUNINGSIH
Published: January 2022

Kebijakan mengenai sistem pembelajaran daring tiap jenjang pendidikan mulai diberlakukan di Indonesia sejak diumumkannya kasus pertama Covid-19 pada Maret 2020. Pada Sekolah Menengah Kejuruan (SMK) Program Keahlian Teknik Komputer dan Informatika baik guru maupun siswa, dianggap lebih mudah melakukan pembelajaran khususnya praktikum daring dikarenakan standar kompetensi untuk jurusan ini dapat dicapai dengan menggunakan perangkat komputer personal saja. Penelitian ini bertujuan mengukur tingkat kesiapan guru SMK Program Keahlian Teknik Komputer dan Informatika terhadap pembelajaran daring berdasarkan beberapa komponen, seperti Strategi Mengajar,  Kemampuan Mengajar, Kebijakan, serta Waktu dan Finansial. Hasil penelitian menunjukkan bahwa para guru dinilai masih belum siap dalam melakukan pembelajaran daring khususnya dari segi Kemampuan Mengajar serta Waktu dan Finansial.Kata kunci: E-learning Readiness, Pembelajaran Daring , Pandemi Covid-19
MOBILE APPLICATION GREEN INDUSTRY BERBASIS CLOUD UNTUK MANAGEMENT DATA WAREHOUSE PADA UKM MENGGUNAKAN TEKNOLOGI QR CODE
Authors: RIZAL MUHAMMAD , RUSMIN MUHAMMAD
Published: January 2022

Penelitian ini bertujuan untuk membuat suatu aplikasi sistem manajemen data pada UKM atau perusahaan dengan memanfaatkan penyimpanan berbasis Cloud serta teknologi penerjemah QR Code dalam satu software untuk memudahkan dalam sisi fleksibilitas. Metode yang digunakan dalam pembangunan sistem ini menggunakan System Development Life Cycle (SDLC) dengan pendekatan model waterfall. Hasil penelitian ini menunjukkan bahwa sistem ramah lingkungan diterapkan untuk mendorong UKM atau perusahaan dalam mengurangi tingkat penggunaan energi sekaligus biaya hingga 60% pada proses pengaplikasiannya. Kata kunci: ramah lingkungan, Cloud, QR Code, manajemen data.
IMPLEMENTASI METODE ANALYTICAL HIERARCHY PROCESS (AHP) DAN SIMPLE ADDITIVE WEIGHTING (SAW) UNTUK PENENTUAN PENERIMA BANTUAN SOSIAL COVID-19
Authors: MUNANDAR AHMAD KHARIS , AL AMIN IMAM HUSNI
Published: January 2022

Pandemi covid-19 telah sangat mempengaruhi seluruh lapisan masyarakat. Area yang paling berpengaruh karena pandemi ini adalah kejahteraan sosial. Pemerintah telah meluncurkan program bantuan sosial untuk keluarga miskin yang rentan terkena dampak dari covid-19. Dalam pelaksanaan pemberian bantuan  ini disambut baik oleh masyarakat, Akan tetapi timbul permasalahan lain, yaitu bahwa sebagian bantuan sosial tersebut tidak tepat sasaran. Penelitian ini mengambil sampel di kabupaten Demak Jawa Tengah, didalam penelitian ini penggunaan metode AHP yaitu pembobotan nilai pada kriteria yang telah ditetapkan, dan SAW untuk menentukan nilai perangkingan pada alternatif yang ada. Hasil  penelitian ini berupa sistem yang dapat di gunakan untuk menentukan calon penerima bantuan sosial covid-19 dengan lebih cepat, transparan dan dapat menghindari penilaian secara subjektif sehingga lebih tepat sasaran.Kata Kunci : AHP , Bantuan Sosial, Covid-19, SAW.
THE COMBINATION OF INQUIRY, LEARNING COMMUNITY, AND TOTAL PHYSICAL RESPONSE: A STUDY ON DEVELOPING ENGLISH LANGUAGE SKILL FOR ELEMENTARY SCHOOL STUDENTS
Authors: Herwanis Delfia
Published: January 2022

The performance of the English language skill of the fifth graders of SD Negeri 1 Takengon was unsatisfactory (avarage score = 34). The limited achievement was due to ineffective teaching and learning process. Therefore, it was suggested that a specific treatment of learning process needs to be well performed. This study aims at finding out if the combination of the Inquiry, Learning Community, and Total Physical Response is able to develop the performance of the students’ English language skill. The study focuses on the students’ performance to verbally respond to any simple instruction with acceptable actions within the context of classroom and school environment; and verbally express any expression of the following speech acts as: giving examples to do something, gesticulation, and giving directions (Departemen Pendidikan Nasional, 2006). In terms of the speaking skill, this study just concentrates on pronunciation and comprehension aspects. To achieve the goal of the study, an experimental approach with the one-group pre-test and post test design was used. The sample for the treatment was 20 students out of 58 students population which was selected randomly. The result shows that the performance of the students’ English language skill in terms of comprehension and pronunciation was significantly improved (34 to 60). In conclusion, the research questions of this research are answerable—the combination of Inquiry, Learning Community, and Total Physical Response does lead to developing students’ English ability in responding to simple instructions, and in expressing such speech acts as giving examples to do something, gesticulation, and giving directions. The hypothesis (Ha) of this research is then accepted as it provides a positive impact for the development of the students’ English language ability, particulary in the area of focus of the study.
PERANAN MEDIA SOSIAL DALAM PENINGKATAN MOTIVASI BELAJAR PESERTA DIDIK PADA MATA PELAJARAN QUR’AN HADIS KELAS VIII MTS MADANI ALAUDDIN PAOPAO KABUPATEN GOWA
Authors: Jalil Abdul , Hafid Erwin , Amri Muhammad , Mosiba Risna
Published: January 2022

Peranan media sosial bagi peserta didik kelas VIII pada mata pelajaran Qur’an Hadis MTs Madani Alauddin Pao-pao Kabupaten Gowa yaitu dengan mendayagunakan media sosial whatsApp dan telegram sebagai instrumen komunikasi dan ruang belajar, serta pendayagunaan media sosial youtube sebagai instrumen belajar dan sumber belajar. Motivasi belajar peserta didik dengan menggunakan media sosial terangkum dalam: Motivasi belajar peserta didik dengan menggunakan whatsApp dan telegram, motivasi belajar peserta didik dengan menggunakan youtube dan faktor-faktor yang mempengaruhi motivasi belajar peserta didik. Peranan media sosial whatsApp dan telegram  meliputi; peserta didik tekun dalam mengerjakan tugas dan menampakkan keuletan dalam belajar mandiri. Peranan media sosial youtube yaitu; meningkatkatkan kreatifitas peserta didik dan membuat peserta didik menyenangi pelajaran Qur’an Hadis. Keterbatasan pembelajaran dengan menggunakan media sosial yakni pembelajaran dengan media sosial betumpuh pada kekuatan signal.
HUBUNGAN PEMBERIAN REWARD AND PUNNISHMENT TERHADAP MINAT BELAJAR SISWA DALAM MATA PELAJARAN PENDIDIKAN AGAMA ISLAM KELAS 4 DI SDN CILENDEK 2 KOTA BOGOR
Authors: Zein Zeinia Tursina
Published: January 2022

Interest is a very important factor in student learning activities. To increase students interest in learning, there are many ways that a teacher can do, one of which is by using the Reward and Punnishment methods. This study aims to determine how much the relationship between reward and punishment towards students' interest in learning in Islamic religious education subjects. The method in this research uses a quantitative approach. This study took a sample of grade 4 SD with a population of 25 students. Data collection techniques in this study using questionnaires, interviews and documentation. The result of this research is that the correlation value between Variable X and Variable Y is 0.922. When viewed from the interpretation table, the correlation index obtained is between 0.90-1.00 which means there is a positive relationship between Variable X and Variable Y which is included in the correlation. or a very strong or very high relationship between the giving of Reward and Punnishment on Students Learning Interests in Islamic Religious Education Subjects. Then by looking at the table the value of r is N = 25. With the value of r-Table at the significance level of 5% = 0.396 and 1% = 0.505. So at a significance level of 5% = 0.922> r-Table 0.396 and 1% = 0.922> r-Table 0.505, it means that Ha is accepted and H0 is rejected. The data obtained showed that there was a significant relationship between the Giving of Rewards and Punnishment on Students Learning Interest in the 4th grade Islamic Religious Education subject at SDN Cilendek 2, Bogor City.
ANTI-COVID HADITH: MAQĀṢIDĪ ANALYSIS ON THE PROPHET’S GUARANTEE ON MEDINA’S STERILITY FROM ṬĀ‘ŪN
Authors: Akbar Akbar , Ahmad Arifuddin , Alwi Zulfahmi , S. Puyu Darsul
Published: January 2022

The insignificance of modern reality to the Prophet Muhammad [pbuh]’s statements and policies determines hadith misperception. This research examines the Prophet Muhammad [pbuh]’s assurance that Madinah was sterile from the ṭā‘ūn as a pandemic, even though Madinah was also infected with Covid-19. This study used a qualitative design utilizing library data based on al-Kutub al-Tis‘ah.  The takhrij al-ḥadīṡ technique was used to track down the data that analyzed using an integrative technique developed by Ma‘ānī al-Ḥadīṡ and Maqāṣid al-Syarī‘ah. The findings revealed that the Prophet’s declaration about Madinah’s sterility due to the disease was part of his strategy for preserving the socio-political stability of Muslims who were pioneering a new civilization. Ḥifẓ al-daulah is a notion in Maqāṣid al-Syarī‘ah, it must be taken into consideration when attempting to determine the maqāṣid of each message and the Prophet. It can dispel the perception that the Prophet Muhammad’s hadith is irrelevant to the reality of modern life.ملخصإن عدم أهمية الواقع الحديث لأقوال الرسول صلى الله عليه وسلم وسياساته يحفز على سوء فهم الحديث. يفحص هذا البحث تأكيد النبي أن المدينة المنورة كانت عقيمة منذ ظهورها على أنها جائحة، على الرغم من إصابة المدينة المنورة أيضًا بـ Covid-19. استخدمت هذه الدراسة تصميمًا نوعيًا باستخدام بيانات المكتبة بناءً على الكتب التسعة. تستخدم تقنية تخريج الحديث لتعقب البيانات ثم تحليلها بتكاملية طورها علم معاني الحديث ومقاصد الشريعة. وكشفت النتائج أن إعلان الرسول صلى الله عليه وسلم عن عقم المدينة المنورة بسبب المرض هو جزء من استراتيجيته للحفاظ على الاستقرار الاجتماعي والسياسي للمسلمين الذين يقودون حضارة جديدة. حفظ الدولة كمقاصد الشريعة الذي يجب أن يؤخذ في الاعتبار عند محاولة تحديد مقاصد كل رسالة النبي. يمكن أن تبدد الفكرة القائلة بأن أحاديث النبي لا علاقة له بواقع الحياة الحديثة.
فن النشيد الإسلامي في تصور الحديث النبوي /THE CONCEPT OF THE PROPHET'S HADITH ON ISLAMIC NASYID ART
Authors: Pallawagau Baso , Hafid Erwin , Ahmad La Ode Ismail , Rasna Rasna
Published: January 2022

صار لفظ النشيد الإسلامي لغة العصر، فالناس يحبون ويتداولون الأغاني الدينية من كبار السن حتى الأطفال فمن الضروري في العصر الحاضر أن يكون مفهوم فن النشيد من منظور إسلامي، حيث يصبح العديد من الناس عبيدًا لحرية لا يمكن أن يسيطر عليها الوعي الذاتي للإنسان، ويبدو أن الناس مغمورون في عالم الترفيه المفرط ويخالفون الحدود التي حددتها الشريعة الإسلامية، فأراد الباحثون أن يبينوا مفهوم النشيد، وموقف الحديث النبوي من النشيد، والآثار الحكمية للنشيد في الحديث النبوي. والمنهج المتبع في هذا البحث هو المنهج الوصفي الاستقرائي، وذلك بجمع الأحاديث المتعلقة بالغناء والموسيقى وهما جزء من النشيد. والطريقة المستخدمة لتحليل البيانات هي دراسة مكتبية وطريقة تحليلها وصفية. ونتيجة البحث تشير إلى أن مفهوم النشيد وأحكامه واختلاف العلماء فيه قد ورد في الأحاديث النبوية بيانه. وهذا البحث له آثار لفهم القيم الحقيقية للفن الإسلامي وخاصة لجيل المسلم الذي يواجه مشاكل الحياة الحديثة المعقدة، حتى يصبح جيلا متحضرا ومتأدبا.الكلمات المفتاحية: النشيد، الغناء، الموسيقى ABSTRACTIslamic Nasyid is a contemporary issue. People are increasingly liking and enjoying religious songs, from parents to children. In the modern era, the concept of art in an Islamic perspective is needed, where many humans become slaves to freedom that a human's self-awareness cannot control. Humans seem to be immersed in the world of excessive entertainment and violate the boundaries that the Shari'a has determined. Therefore, the author wants to explain the essence of nasyid art, the view of the Prophet's hadith on nasyid and the legal consequences of nasyid in the Prophet's hadith. This study is a literature review, classical and contemporary. The method used is a qualitative method with a descriptive approach by collecting hadiths related to songs and music as part of nasyid. For data processing, the methods used are library research and descriptive analysis methods. The study results indicate that the understanding of nasyid, the law and the differences between the scholars in it has been explained in the hadith of the Prophet. Therefore, this paper has implications for understanding the actual values of art, especially for the millennial Muslim generation who face complex modern life problems to become a civilized Muslim generation.