bluuebunny/crossref_metadata_2025 huggingface dataset:
Rib cartilage, the panacea for post traumatic mid face deformity
Authors: Munjal Manish , Munjal Shubham , Nahar Amandeep , Sharma Salony , Chawla Deeksha , Kaur Hardeep , Sandhu Loveleen , Gill Ruchika , Chahal Jasmeen , Rishi Ojassivi , Joshi Tanvi
Published: December 2022

Reconstitution of the facial profile can be achieved in a depressed‘midface “, by supplementation of the nasal osteo-cartilagious skeleton utilizing autologous tissue or synthetic prosthesis, Bone from the iliac crest and cartilages from the septum, cymba conchal and the rib are the accepted grafts in wide use. The costo-chondral junctional cartilage is ideal in situations demanding excess of graft, then can be harvested from the ear or the septum. Moreover, this graft though easily cut and mouldable, gives a rigid sharp profile to the nose. Utilization of the rib cartilage in a young gentleman with a post traumatic midrace deformity is being described.

 
Basal cell carcinoma of the ala of nose: a case report
Authors: Prathyusha G , Singh T. Dinesh , Kiran G. Abhinav
Published: December 2022

Basal cell carcinoma (BCC) of nose is common with potential of local recurrence and high risk features. We are reporting a case of BCC on the right ala of nose in an elderly female patient hailing from rural background, who came to our OPD for cosmetic outcome. She was treated with wide local excision with nasolabial flap reconstruction. The tissue when sent for HPE came up with BCC with margin involvement. Hence she was sent to chemoradiotherapy after 3 weeks of surgery, after complete wound healing.

 
A rare tumor at a rare location: facial nerve schwannoma
Authors: Doloi Pankaj Kumar , Sharma Mitesh Kumar
Published: December 2022

Schwannomas are benign, slow-growing tumours arising from Schwann cells within the nerve sheath with no gender preferance. We present a 29-year-old female patient attending ENT OPD at St. Stephens Hospital, New Delhi with complain of left-sided infrauricular, painless swelling for 3 months which was insidious in onset, and progressive in nature. NCCT neck showed enlarged left parotid gland and USG showed a cystic lesion in left parotid tissue. Superficial parotidectomy was planned according to the above findings and the sample was sent for histopathological examination. IHC markers were applied and features were suggestive of benign peripheral nerve sheath tumor favoring schwannoma. Schwannomas can sometimes mimic as enlarged parotid tumour in its rarest presentation. This case report is in view of evaluating parotid mass in a broader aspect and manage accordingly.
Intermediate osteotomy: the vital pivot, in the wide nose
Authors: Munjal Manish , Munjal Shubham , Arora Vineeta , Sharma Salony , Talwar Shivam , Chawla Deeksha , Kaur Hardeep , Grewal Mehtab , Gupta Vasu , Bharadwaj Iti , Sidhu Kanwarpreet , Joshi Tanvi
Published: December 2022

Deviations and deformities of the bony nasal skeleton are amenable to osteotomies in the longitudinal, transverse and the oblique planes. These interventions undertaken either intranasal or percutaneous, translocate the osteo-cartilaginous nasal segments as a single entity. The intermediate osteotomy is usually resorted to, in three situations, namely; a very broad nose with a good nasal height, a deviated nose with a lateral wall longer than the opposite and where required to straighten an excessively convex nasal bone. A lady with quite a broad nose was subjected to bilateral osteotomies of the ‘intermediate’ type, to achieve aesthetic social acceptability.
MEMÓRIAS E TRAJETÓRIA DOCENTE: RELATOS DE UMA PROFESSORA
Authors: De Oliveira Gomes Joanderson , Assis Francymara Antonino Nunes de , Resende Soares Maria Valdenice
Published: December 2022

Resumo: O presente estudo tem o objetivo de refletir sobre os percursos formativos e o trabalho docente de uma professora da educação básica com atuação profissional em diversas cidades do Vale do Mamanguape, Paraíba. Entendemos que o trabalho com as histórias de vida de educadoras pode contribuir para a construção da história da educação e da história da mulher, a partir da recuperação da memória feminina. Optamos pelo recurso metodológico das narrativas (auto) biográficas, ou seja, tomamos a própria história narrada como cerne do estudo. A apreciação das narrativas nos permitiu desvelar, mesmo que de forma parcial, representações do ser professor, conhecimentos construídos nos diversos percursos formativos, o significado social da profissão, conhecimentos pedagógicos, diálogo entre teoria e prática e aspectos da construção da identidade docente.
Palavras-chave: Mulheres; Educadoras; (Auto) Biografias; Narrativas de Vida.
 
Abstract: the present study aims to reflect on the formative paths and the teaching work of a basic education teacher with professional experience in several cities of Vale do Mamanguape, Paraíba. We understand that working with the life stories of educators can contribute to the construction of the history of education and the history of women, based on the recovery of female memory. We opted for the methodological resource of (auto) biographical narratives, that is, we took the narrated story itself as the core of the study. The appreciation of the narratives allowed us to reveal, even if partially, representations of being a teacher, knowledge built in the different training paths, the social meaning of the profession, pedagogical knowledge, dialogue between theory, and practice and aspects of the construction of teaching identity.
Keywords: Women; Educators; (Self) Biographies; Life Narratives.
NARRATIVAS SOBRE OS ROTEIROS HISTÓRICOS DA IGREJA PRESBITERIANA DO RECIFE ATRAVÉS DO ADVENTO DO MOVIMENTO FUNDAMENTALISTA NA CAPITAL PERNAMBUCANA
Authors: Santos Saymmon Ferreira
Published: December 2022

Resumo: À luz das primeiras trilhas do trabalho presbiteriano em Pernambuco, encontra-se a presença do missionário estadunidense Rev. John Rockwell Smith, que, com a adesão de um pequeno grupo, constituiu a primeira Igreja Presbiteriana de Pernambuco em 1878. Após 78 anos de constituição, a igreja foi palco de uma crise que promoveu o seu desligamento da Jurisdição da Igreja Presbiteriana do Brasil, com o advento do movimento fundamentalista na cidade do Recife. Analisaremos neste artigo a construção histórica do presbiterianismo local a partir da Igreja Presbiteriana do Recife, tendo como recorte temporal o ano de sua fundação até 1995.
Palavras-chave: Igreja Presbiteriana do Brasil; Fundamentalistas; Presbiterianismo no Recife.
 
Resumen: A la luz de las primeras huellas de la obra presbiteriana en Pernambuco, se hizo presente el misionero americano Rev. John Rockwell Smith, quién, con la adhesión de un pequeño grupo, constituyó la primera Iglesia Presbiteriana de Pernambuco en 1878. Después de 78 años de constitución, la iglesia fue escenario de una crisis que promovió su separación de la Jurisdicción de la Iglesia Presbiteriana de Brasil, con el adviento del movimiento fundamentalista en la ciudad de Recife. En este artículo, vamos analizar la construcción histórica del presbiterianismo local tomando como punto el surgimiento de la Iglesia Presbiteriana de Recife, con su marco temporal desde el año de su fundación hasta 1995.
Palabras clave: Iglesia Presbiteriana de Brasil; Fundamentalistas; Presbiterianismo en Recife.
ALINHAVOS PARA UMA HISTÓRIA DA MODA
Authors: Silva Karen Pereira Freitas da
Published: December 2022

Resumo: a moda se manifesta materialmente, expressando elementos que constituem momentos históricos. Ela é repleta de subjetividade, dos desejos e poderes dos sujeitos nela envolvidos. Estes aspectos revelam sua essência paradoxal coexistindo com seu devir transformador. As inquietações que motivam este estudo são a reserva na abordagem da moda pela história e qual a sua relevância para a ciência histórica. Por meio de um balanço historiográfico composto por cinco autores que discutem a moda de diferentes ciências, teorias e métodos, é possível realizar uma reflexão ampla, de modo que haja compreensão não só do significado da moda, mas também da sua contribuição na construção da história, uma vez que o ato de se cobrir e se ornar acompanha o ser humano desde os primórdios.
Palavras chave: História; Moda; Teoria.
 
Abstract: fashion manifests itself materially, expressing elements that constitute historical moments. It is full of subjectivity, desires, and powers of the subjects involved in it. These aspects reveal its paradoxical essence coexisting with its transforming becoming. The concerns that motivate this study are the reservation in the approach of fashion through history and its relevance to historical Science. Through a historiographical balance composed of five authors who discuss Fashion from different sciences, theories and methods, it is possible to carry out a broad reflection, so that there is an understanding not only of the meaning of fashion but also of its contribution to the construction of history since the act of covering and adorning oneself accompanies the human being since the beginning.
Keywords: History; Fashion; Theory.
"CASA-GRANDE DE DETENÇÃO DA CULTURA"
Authors: Silva Luz Iago Tallys , Castelo Branco Brito Fábio Leonardo
Published: December 2022

o presente estudo objetiva compreender a atuação e produção de uma contracultura no Recife-PE de 1960-1970, através de parte das produções e críticas realizadas pelo professor, pop filósofo, poeta e filmaker pernambucano Jomard Muniz de Britto, especialmente dirigidas à Gilberto Freyre, pensadas como representações de um debate cultural vigente na cidade. Para tanto, utiliza-se como fontes principais livros como: Tempo de Aprendiz (2016) de Gilberto Freyre, Interpenetrações do Brasil (2002a) e Atentados Poéticos (2002b) e o filme O Palhaço Degolado (1977), vinculados à Jomard Muniz de Britto. Como bibliografia, destacam-se nomes como: Durval Albuquerque Júnior (2011, 2013a e 2013b) e Antonio P. Rezende (1997).
Comparison of effectiveness of metronidazole, chlorhexidine, and lignocaine combination gel with that of zinc oxide eugenol dressing for the treatment of alveolar osteitis
Authors: Sachdev Sanpreet Singh , Wadde Kavita , Chhapane Ashwini , Sarda Ashish , Chowdhar Asha , Latke Siddhesh
Published: December 2022

Alveolar osteitis (AO) is the most common complication of dental extractions, especially, the mandibular third molar. Zinc oxide eugenol (ZOE) is commonly used as a surgical dressing for the treatment of AO. However, the search for better dressing materials is still underway. Therefore, the present study aims to evaluate the impact of the intra-alveolar application of Metronidazole (MN), Chlorhexidine (CHX), and Lignocaine (LC) on the treatment of alveolar osteitis and compare it with that of ZOE.

A total sample of n=32 patients was randomly assigned into the experimental group treated with MN+CHX+LC combination, while the control group was treated with ZOE paste dressing. Pain, discomfort, and healing were assessed on 3-day and 2-week follow-ups.

A statistically significant difference was noted in the number of individuals with pain (p=0.006) and halitosis (p=0.002) on the third day follow-up with higher number of individuals in the control group still experiencing the symptoms. By the end of two weeks, all the patients in the experimental group (n=16) had relief from pain and discomfort while they persisted in n=4 patients and halitosis was noted in n=9 patients treated with ZOE dressing.

The experimental combination has a clear advantage as a medicament dressing because of its superior antibacterial and anesthetic properties over ZOE dressings. The combination reduces the time period required for healing the socket in AO, while greatly adding to the patient’s comfort and overall well-being.
Mesiodens - Obvious yet unnoticed: A case report
Authors: Sachdev Sanpreet Singh , Adhane Yogita , Chettiankandy Tabita Joy , Sardar Manisha Ahire , Chhapane Ashwini
Published: December 2022

Supernumerary teeth occurring in between the central incisors are termed ‘mesiodens’ and have a prevalence rate of 3% in the Asian population.Mesiodens in seldom observed in adults with permanent dentition as most of them get extracted within the first decade or early second decade. The present case report describes mesiodens in a 32-year-old male with an emphasis on its radiological and histological aspects. Although a fairly common dental anomaly, mesiodens may present with several complications and have clinical implications in treatment. Retention of mesiodens until the fourth decade is quite unusual and is, therefore, an interesting aspect of the present case.
A retrospective study of prevalance of hepatitis B and hepatitis C virus infections in hemodialysis patients in teritary care hospital Jamnagar
Authors: Chouhan Heena , Parmar Rashmika
Published: December 2022

Patients getting upkeep hemodialysis (HD) are at higher gamble for gaining Hepatitis B infection (HBV) and Hepatitis C infection (HCV) diseases than everybody. Thus, we meant to examine the occurrence and predominance of HBV and HCV contamination in the HD populace in a tertiary consideration clinic Jamnagar.

All grown-up patients getting support HD (n=1667)were read up for quite some time (2019 and 2020). Testing for Hepatitis B surface antigen (HBsAg) and hostile to HCV antibodies was performed at commencement of dialysis and each 3-6 months from that point. A review was done in view of information of serological testing of all CKD Patients.

The middle period of patients was 60 years and 65% were male.1667 patients were concentrated on in which sero positive for HBV (0.83%) and HCV (hostile to HCV 2.57%). The predominance of HBV+HCV contamination differed broadly between HD focuses from 0% to 65.7% sero-positive patients were more youthful, made some more extended memories on dialysis and more past blood bondings. Imminent subsequent uncovered a rate of sero transformation of 0.35% during 1 year. Span of dialysis, more youthful age, and history of getting HD in one more place were altogether connected with sero-change.

Patients on upkeep HD in tertiary consideration medical clinic, Jamnagar have a high frequency and predominance of HCV disease and lower paces of HBV contamination. The elements related with HBV and HCV diseases are exceptionally reminiscent of nosocomial transmission inside HD units. As end, we thus require sufficient improvement in contamination control estimates in Hemodialysis units in order to lessen reliance on blood bondings for the treatment of paleness.
Isolation, identification and antibiotic susceptibility pattern of coagulase –negative staphylococci (cons) in various clinical specimens
Authors: Kaur Kiranjeet , Kaur Jaspreet
Published: December 2022

Coagulase Negative (CoNS) have been recognized as an important agent of human infection since the past five decadesSignificance of CoNS in human infection is increasing these days.CoNS are the indigenous flora of the skin and mucous membrane. They have long been considered as non pathogenic and were rarely reported to cause severe infections. However, as a result of the combination of increased use of intravascular devices and an increase in the number of hospitalized immunocompromised patients, CoNS have become the major cause of Nosocomial blood stream infections and they account for 9% of nosocomial infections.

This study has been done to identify clinically significant CoNS associated with different human infections and also study their antibiotic susceptibility pattern isolated from clinical samples.

: The present study was conducted in a teaching hospital of Punjab, India. A total 52 strains of CoNS isolated as a sole agent with a significant growth from various clinical samples were included in the study. The speciation of CoNS was done based gram staining, catalase test, coagulase test and VITEK – 2 Compact system.

: Out of 52 sample, 61.5% is male and 38.5% female coming. The most common CoNS species isolated were S. hemolyticus 28(54%), S. epidermitidis 8(15%), S.hominis 8(15%) and 8(15%).

The current study shown that pathogenic CoNS cause infection-related signs and symptoms. CoNS was discovered to be isolated from blood, urine, and pus, and were the most often found species in patients.
Ochrobactrum anthropi: An unusual opportunistic pathogen causing septicemia and Pneumonia
Authors: Verma Sameer Rajeev , Sardana Vandana
Published: December 2022

is being increasingly recognized as an opportunistic human pathogen, causing severe infections mostly in debilitated or immunocompromised patients. It has been implicated in causing nosocomial infections, particularly in those with indwelling catheters, which can lead to catheter-related bloodstream infections. We report the constellation of clinical, microbiological and radiological ﬁndings of a case of septicemia and pneumonia caused by this unusual pathogen. Treatment of  anthropi infection is challenging because of an unpredictable resistance to antibiotics. Correct identification and timely initiation of an appropriate antimicrobial therapy proves to result in the dramatic recovery of the patient.
Comparison of ocular trauma between normalized and the COVID-19 epidemic periods in China: a multi-center cross-sectional study
Authors:   Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China, Zhang Ya-Xin , Liao Meng-Yu ,   Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China, Yan Hua ,   Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Medical University, Tianjin 300070, China
Published: December 2022

AIM: To compare the feature of ocular trauma between normalized period and the COVID-19 epidemic period in China, and to provide a profile for eye injuries in special times in future.
METHODS: This is a multi-center cross-sectional study with 30 participated hospitals involving the China Ocular Trauma Society members. All hospitalized cases who visited the Ophthalmology Department in participated hospitals with eye injuries during the normalized period (2019) and the COVID-19 epidemic period (2020) were included in this study. Demographic characteristic of cases, date of injury, sites and types of injury were collected.
RESULTS: This study involved 13 525 (61 cases with both eyes) injured cases. There were 7269 (53.74%) eye-injured cases and 6256 (46.26%) eye-injured cases in 2019 and 2020 separately. Compared with 2019, the incidence of ocular trauma in retirees, housewives and unemployed increased with year-on-year of 4.96%, 102.67%, and 11.64% among all occupations. In 2020, the incidence of eye injuries decreased in all injury sites except for an increase in home (30.29% year-on-year). The incidence of mechanical eye injuries decreased, while that of non-mechanical eye injuries (chemical/thermal/radiation) increased (47.45% year-on-year). There were 255 (3.51%, 255/7269) and 376 (6.01%, 376/6256) non-mechanical injured cases in 2019 and 2020 (Pearson Chi2=47.33, P<0.001) separately.
CONCLUSION: During the COVID-19 epidemic period, the total cases of ocular trauma decrease but the proportion of non-mechanical ocular trauma increase. Penetrating is still the highest proportion among all types of mechanical ocular trauma. From a preventive point of view, protection for retired persons, housewives and unemployed persons should be improved during public health events period.
COVID-19 pandemic impact on ocular trauma in a tertiary hospital
Authors:   The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan Province, China; Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Xu You-Mei , Huo Ya-Dan ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, An Guang-Qi ,   The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan Province, China, Jin Xue-Min ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Zhou Peng-Yi ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Published: December 2022

AIM: To analyze the impact of the coronavirus disease- 2019 (COVID-19) pandemic on the presentation and characteristics of patients hospitalized for ocular trauma in a tertiary hospital in China between 2019 and 2020.
METHODS: A retrospective case study was designed to collect information on all cases of ocular trauma in a tertiary hospital from 2019 to 2020 and compare differences in inpatients’ data (age, sex, admission vision acuity, type of diagnosis, hospital stays, mechanism of injury and location of injury).
RESULTS: The total number of patients admitted to the Ophthalmology Department was 883 (mean 73.58±11.25 patients per month) in 2019 and 714 (59.50±17.92 patients per month) in 2020. The injury number of in work was also the most within the four types of location in this two year (42.36% in 2019, 43.84% in 2020). The mean hospital stays were 12.66d in 2019 and 10.81d in 2020. The highest incidence of ocular trauma was the middle-aged (41-65y) groups in 2019 and 2020. The most common cause of ocular trauma was sharp object in 2019 (47.34%) and 2020 (47.58%). The mechanical ocular trauma reaches 98.98% in 2019 and 99.72% in 2020.
CONCLUSION: The number of patients with ocular trauma decreased in 2020, but middle-aged (41-65y) are still high incident groups. Mechanical ocular trauma remains the leading cause of hospitalization for ocular trauma patients and the proportion of patients injured at home increases. It is necessary to arouse social attention and the public’s awareness of eye trauma protection should be strengthened during the pandemic.
Apolipoprotein A1 suppresses the hypoxia-induced angiogenesis of human retinal endothelial cells by targeting PlGF
Authors:   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China, Hu Jie , Su Kun-Yi ,   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China, Lian Yu ,   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China, Lu Lin ,   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China, Hu An-Di-Na ,   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China
Published: December 2022

AIM: To investigate the anti-angiogenic effect of apolipoprotein A1 (apoA1) on primary human retinal vascular endothelial cells (HRECs) and explore the possible mechanism.
METHODS: The primary HRECs were transfected with apoA1-GFP recombinant lentiviral and were compared with cells undergoing transfection with empty lentiviral vectors. Hypoxia chambers were used to simulate the anoxic environment of cells under pathological condition. The concentrations of secreted vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay (ELISA). Cell migration ability was detected by wound healing assay. The sprouting of HRECs was determined by tube formation assay. The protein levels of extracellular signal regulated kinase 1/2 (ERK1/2) and phosphorylated ERK1/2 (p-ERK1/2) were measured by Western blot.
RESULTS: Overexpressed apoA1 in hypoxia-induced HRECs significantly suppressed PlGF (0.67±0.10 folds, P=0.007). Overexpressed apoA1 also attenuated hypoxia-induced cell migration (0.32±0.11 folds, P<0.0001), tube formation (0.66±0.01 folds, P<0.0001) and the phosphorylation levels of ERK (0.6±0.11 folds, P=0.025). Pretreatment of mitogen-activated protein kinase kinase (MEK) inhibitor (U0126) further reduced the PlGF and angiogenesis in hypoxia-induced HRECs.
CONCLUSION: ApoA1 inhibits the angiogenesis at least in part by inactivating ERK1/2 in hypoxia-induced HRECs. Moreover, apoA1 suppresses the PlGF expression, which selectively associated with pathological angiogenesis.
Identifying a novel frameshift pathogenic variant in a Chinese family with neurofibromatosis type 1 and review of literature
Authors:   Senior Department of Ophthalmology, the Third Medical Center of PLA General Hospital, Beijing 100039, China, Guo Xiao-Hui , Wang Bin ,   Department of Otolaryngology, Peking Union Medical College Hospital, Beijing 100730, China, Wang Zhao-Yan ,   Senior Department of Ophthalmology, the Third Medical Center of PLA General Hospital, Beijing 100039, China
Published: December 2022

AIM: To detect the pathogenic gene variant in a family with neurofibromatosis type 1 (NF1).
METHODS: This patient with NF1 was sequenced using target sequence capture and high-throughput sequencing technology. After detecting the suspicious pathogenic variant type, the pathogenic variant sites of the patient and the patient’s family members were verified by multiple ligation dependent probe amplification and Sanger sequencing. Sift, polyphen-2, Mutation Taster and GERP++ software were used to predict the pathogenicity of the unknown loci. The clinical data, diagnosis and treatment process of the patients were reviewed. Using the keyword “NF1; frameshift pathogenic variant”, relevant literature was gathered for analysis from Chinese and international databases, with articles dating from the establishment of each database to April 2022.
RESULTS: A heterozygous frameshift pathogenic variant of NF1 in exon 33 was detected in the patient. The insertion of adenine in coding region 4486 resulted in the replacement of isoleucine with asparagine in protein 1497. Sanger sequencing validation and segregation analysis were performed, which demonstrated that the NF1 gene was cosegregated with the disease phenotype in this family. This study identified a novel NF1 heterozygous frameshift mutation c.4486dupA (p.I1497Nfs*12). Relevant literature retrieval found 7 Chinese articles and 12 foreign articles. With NF1 gene mutation, mutation types are diverse, including point mutation, frameshift mutation, splice site mutation, exon mutation, chimeric mutation and de novo mutation. Foreign reports are based on autosomal dominant inheritance.
CONCLUSION: This study’s results demonstrate that a novel deletion in exon 33 caused NF1 in this Chinese family, expanding the mutational spectrum of the NF1 gene.
Macular vascularisation changes analysed using OCT angiography after successful rhegmatogenous retinal detachment repair
Authors:   Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66421, Germany, Hartmann Marie , Fraenkel Doris ,   Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66421, Germany, Munteanu Christian ,   Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66421, Germany, Seitz Berthold ,   Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66421, Germany, Suffo Shady ,   Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar 66421, Germany
Published: December 2022

AIM: To analyse the macular vascularisation changes analysed using optical coherence tomography angiography (OCTA) after successful rhegmatogenous retinal detachment (RRD) repair by comparing gas vs silicone oil and macula-on vs macula-off.
METHODS: This retrospective data collection included 77 eyes with RRD that underwent pars plana vitrectomy (PPV) and gas or silicone oil tamponade. We performed an OCTA during the postoperative control between 6 and 24mo after the last surgery and evaluated the main parameters measured by OCTA: foveal avascular zone (FAZ) and parafoveolar vascular density (PVD) in the superficial capillary plexus. The patients were divided into four groups: RRD with macular involvement treated with gas tamponade, RRD without macular involvement treated with gas tamponade, RRD with macular involvement treated with silicone oil tamponade and RRD without macular involvement treated with silicone oil tamponade. A one-way ANOVA test combined with post hoc Bonferroni corrections compared FAZ sizes and PVD in all four groups.
RESULTS: The FAZ size was statistically significantly larger in eyes with RRD involving the macula than in those not involving it (P=0.005). There was no statistically significant difference in the FAZ sizes of the eyes treated with silicone oil tamponade compared to those treated with gas tamponade (P=0.54). There was no statistically significant difference in the PVD comparing all four groups.
CONCLUSION: Despite the known risks associated with silicone oil, our findings suggest that the type of tamponade used during PPV to treat an RRD has no significant effect on the future integrity of the PVD or the size of the FAZ in the superficial capillary plexus as measured by OCTA.
Morphological and functional changes in the macular area in diabetic macular edema after a single intravitreal injection of aflibercept
Authors:   Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen 518031, Guangdong Province, China, Zhang Chuan-He , Huang Chao ,   Department of Ophthalmology, Jinan Second People’s Hospital, Jinan 250001, Shandong Province, China, Shu Xiang-Wen ,   Department of Ophthalmology, Jinan Second People’s Hospital, Jinan 250001, Shandong Province, China, Chen Tian-Yu ,   Medical Department, Wuxi Second People’s Hospital, Wuxi 214001, Jiangsu Province, China, Chen Xuan ,   Department of Ophthalmology, Jinan Second People’s Hospital, Jinan 250001, Shandong Province, China, Wu Chang-Long ,   Department of Ophthalmology, Jinan Second People’s Hospital, Jinan 250001, Shandong Province, China, Wang Yu ,   Department of Ophthalmology, Jinan Second People’s Hospital, Jinan 250001, Shandong Province, China
Published: December 2022

AIM: To evaluate the changes in macular morphology and function after a single intravitreal injection of aflibercept in diabetic macular edema (DME) using optical coherence tomography angiography (OCTA) and MP-3 microperimetry.
METHODS: Twenty-eight patients (42 eyes) diagnosed with DME were treated with intravitreal injection of aflibercept. The changes in best corrected visual acuity (BCVA), central retinal thickness (CRT), foveal avascular zone (FAZ) area, vessel density of superficial retinal capillary plexus (SVD), vessel density of deep retinal capillary plexus (DVD), mean light sensitivity (MLS), 2° fixation rate (P1), 4° fixation rate (P2), and other indicators 1mo after treatment were compared; of these, BCVA was converted into logarithm of the minimum angle of resolution (logMAR), and the correlation among the factors was analyzed.
RESULTS: After treatment, logMAR BCVA was 0.47±0.24, which was significantly better than that before treatment (0.63±0.28, P<0.001). The CRT was 359.21±107.87 μm after treatment, which was significantly lower than before treatment (474.10±138.20 μm, P<0.001). The FAZ area, SVD, and DVD were not significantly changed after treatment compared with the baseline. MLS was 22.16±4.20 dB after treatment, which was significantly higher than before treatment (19.63±4.23 dB, P<0.001). P2 significantly increased after treatment than before treatment (P=0.007). P1 had no significant change after treatment than before treatment (P=0.086).
CONCLUSION: A single intravitreal injection of aflibercept effectively reduces macular edema and improves retinal sensitivity, fixation stability, and visual acuity, possibly without causing significant changes in the retinal vascular condition in a short time.
Changes of optic nerve head microcirculation in high myopia
Authors:   Department of Ophthalmology, Hunan Children’s Hospital, Changsha 410007, Hunan Province, China, Tang Wen-Quan , Wang Xi-Lang ,   Department of Ophthalmology, Hunan Children’s Hospital, Changsha 410007, Hunan Province, China, Duan Xuan-Chu ,   Changsha Aier Eye Hospital, Changsha 410011, Hunan Province, China; Aier School of Ophthalmology, Central South University, Changsha 410011, Hunan Province, China
Published: December 2022

AIM: To analyze the correlation of age, spherical equivalent (SE), and axial length (AL) with the microcirculation of optic nerve head (ONH) in high myopia (HM).
METHODS: In this cross-sectional clinical study, 164 right eyes were included. Optical coherence tomography angiography (OCTA) was used to detect ONH vessel density. Eyes were classified based on age, SE, and AL. Groups of Age1, Age2, and Age3 were denoted for age classification (Age1<20y, 20y≤Age2<30y, Age3≥30y); Groups SE1, SE2, and SE3 for the SE classification (-9≤SE1<-6 D, -12≤SE2<-9 D, SE3<-12 D); Groups AL1, AL2, AL3, and AL4 for the AL classification (AL1<26 mm, 26≤AL2<27 mm, 27≤AL3<28 mm, AL4≥28 mm).
RESULTS: No significant difference was observed in vessel density among the Age1, Age2, and Age3 groups (all P>0.05) and the SE1, SE2, and SE3 groups (all P>0.05). No significant difference was observed in the intrapapillary vascular density (IVD) among AL1, AL2, AL3, and AL4 groups (P>0.05). However, a significant decrease was found in the peripapillary vascular density (PVD) in the AL1, AL2, AL3, and AL4 groups (F=3.605, P=0.015), especially in the inferotemporal (IT; F=6.25, P<0.001), temporoinferior (TI; F=2.865, P=0.038), and temporosuperior (TS; F=6.812, P<0.001) sectors. The IVD was correlated with age (r=-0.190, P<0.05) but not with SE or AL (P>0.05). The PVD was correlated with AL (r=-0.236, P<0.01) but not with age or SE (P>0.05).
CONCLUSION: With the increase of AL, the IVD remains stable while the PVD decreases, especially in the three directions of temporal (IT, TI, and TS). The main cause of microcirculation reduction may be related to AL elongation rather than an increase in age or SE.
Association between vision and cognitive function among community-dwelling older adults in Selangor, Malaysia
Authors:   Programme of Optometry and Vision Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia, Mohammed Zainora , Fadzil Norliza Mohamad ,   Programme of Optometry and Vision Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia, Rahman Mohd Harimi Abd ,   Programme of Optometry and Vision Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia, Din Normah Che ,   Centre for Rehabilitation and Special Needs Study, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia, Mariappan Vanitha ,   Center of Toxicology and Risk Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia, Shahar Suzana ,   Programme of Dietetic, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.
Published: December 2022

AIM: To determine the association between distance and near visual acuity (VA) and cognitive function among older adults in Selangor, Malaysia.
METHODS: A total of 230 older adults (age ≥60y) participated in this study. Habitual distance and near VA were measured using the Early Treatment Diabetic Retinopathy Study Chart and Lighthouse Near Visual Acuity Chart, respectively. Global cognitive function was assessed using the Mini-Mental State Examination (M-MSE) and the Malay language version of the Montreal Cognitive Assessment (M-MoCA). Digit Symbol (DS) subtest was used to measure information processing.
RESULTS: No significant association was observed between vision and M-MSE and M-MoCA scores. However, poor distance and near VA were found to be significantly associated with low DS scores [distance VA: β=-0.01, R2=0.1, P=0.02; odds ratio (OR)=2.84, 95% confidence interval (CI), 1.10-7.33, P=0.03; near VA: β=-0.05, R2=0.08, P=0.00; OR=3.32, 95%CI, 1.28-8.59, P=0.01].
CONCLUSION: Poor vision is associated with a decline in information processing in older adults and substantiates the importance of preserving good vision in maintaining cognitive function.
A systematic review of reading tests
Authors:   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece, Ntonti Panagiota , Chatzimichael Eleftherios ,   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece, Panagiotopoulou Eirini-Kanella ,   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece, Bakirtzis Minas ,   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece, Konstantinidis Aristeidis ,   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece, Labiris Georgios ,   Ophthalmology Department, University Hospital of Alexandroupolis, Dragana 68100, Alexandroupolis, Greece
Published: December 2022

Adequate near and intermediate visual capacity is important in performing everyday tasks, especially after the introduction of smartphones and computers in our professional and recreational activities. Primary objective of this study was to review all available reading tests both conventional and digital and explore their integrated characteristics. A systematic review of the recent literature regarding reading charts was performed based on the PubMed, Google Scholar, and Springer databases between February and March 2021. Data from 11 descriptive and 24 comparative studies were included in the present systematic review. Clinical settings are still dominated by conventional printed reading charts; however, the most prevalent of them (i.e., Jaeger type charts) are not validated. Reliable reading capacity assessment is done only by those that comply with the International Council of Ophthalmology (ICO) recommendations. Digital reading tests are gaining popularity both in clinical and research settings and are differentiated in standard computer-based applications that require installation either in a computer or a tablet (e.g., Advanced VISION Test and web-based ones e.g., Democritus Digital Acuity Reading Test requires no installation). It is evident that validated digital tests will prevail in future clinical or research settings and it is upon ophthalmologists to select the one most compatible with their examination routine.
O PROJETO PRÉ-ENEM 2020 DO CAMPUS CATOLÉ DO ROCHA
Authors: Geroleti Luciana Carlos
Published: December 2022

O texto pretende abordar a experiência de aulas remotas para o Exame Nacional do Ensino Médio - ENEM no ano de 2010 através do projeto de extensão realizado no campus Catolé do Rocha denominado PRÉ-NEM. Como se verá, o projeto desenvolvendo discussões diversas, como o racismo estrutural, com foco em formação e aprendizagem.
IMPORTÂNCIA DOS JOGOS E BRINCADEIRAS NA EDUCAÇÃO INFANTIL DA REDE PÚBLICA DE ENSINO
Authors: Silva Leonardo Pereira e , Carvalho Maria das neves de Carvalho Das neves de , Carvalho Danielle Abrantes de Menezes , Carvalho Antônio César de
Published: December 2022

O presente estudo trata de questões relativas ao lúdico, e aborda a temática da importância dos jogos e brincadeiras na educação infantil, que procura levantar questionamentos relacionados a essa importância. Assim, buscou-se uma literatura que enfatizasse o lúdico como estratégia, levando em consideração os instrumentos como os jogos e as brincadeiras na aprendizagem da criança. Para tanto, os fundamentos teóricos estão embasados em autores como: Áries (1979) Antunes (2003) Fontana (1997) Horon (2004) Oliveira (2002) Kramer (2003) Lima (2001) RCNEI em Brasil (1998) entre outros. Portanto, os resultados provenientes das discussões favoreceram as respostas almejadas no objetivo do estudo, no qual busca analisar a importância dos jogos e brincadeiras na educação infantil, como pressuposto a aprendizagem da criança.
Implantação do Grupo de Percussão do IFPB/JP: desafios do universo virtual
Authors: Carneiro Italan , Ferreira Carlos Eduardo Dos Santos , Béchade Luca
Published: December 2022

Neste texto, discutimos os resultados do Projeto de Extensão intitulado “Implantação do Grupo de Percussão do IFPB/JP”, entendendo o Grupo como um laboratório de práticas artístico-musicais que atenderá não somente à comunidade interna da Instituição  mas também aos membros da comunidade em geral. Como característica do Projeto, destacamos a ênfase no trabalho com materiais alternativos (reciclados e objetos do cotidiano), bem como a prática da composição e da improvisação. Como principais resultados do trabalho, ressaltamos a realização da prática musical em conjunto pelos extensionistas, o trabalho com as ferramentas de gravação de áudio e vídeo, a divulgação do repertório (peças) trabalhado e atividades institucionais, assim como a significativa interação entre os membros do Projeto e a comunidade.
A ATUAÇÃO DO ESCRITÓRIO MODELO CACTUS NAS CASAS DE FARINHA DE PRINCESA ISABEL-PB
Authors: Martins Paula Dieb , Tavares Daniela Passos Simões de Almeida , Morais Thais De Freitas , Junior Antônio Gonçalves de Farias , Moreira Fernanda Da Silva de Andrade , Antas Marbson Goulart , Ribeiro Marcos Da Silva , Codogno Vitoria Prates , Morais Amanda Crispim , Da Silva Maria de Lourdes Cândido , Silva Jonatas Tavares da , Medeiros Ana Paula
Published: December 2022

Este artigo relata a experiência obtida a partir da realização do projeto “Escritório Modelo CACTUS” desenvolvido no âmbito do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba Campus Princesa Isabel, entre setembro de 2020 e fevereiro de 2021. O projeto foi contemplado com taxa de bancada e bolsas para aluno através do Edital de Prestação de Serviço PROEXC Nº 15, de 21 de julho de 2020. O objetivo principal do projeto consistiu em promover a autonomia profissional aos alunos para capacitá-los a desenvolver soluções tecnológicas para as demandas locais, integrando os saberes teórico e prático em busca do desenvolvimento sustentável da região. A metodologia de trabalho envolveu planejamento e elaboração de projetos arquitetônicos e ações relacionadas à adequação das Casas de Farinha, localizadas na Zona Rural de Princesa Isabel. Cumpre ressaltar que, diante das limitações impostas pelo trabalho remoto, algumas atividades previstas tiveram que ser adaptadas. Contudo, mesmo diante das dificuldades encontradas, a partir da realização de reuniões, orientações, oficinas e eventos online foi possível não apenas alcançar boa parte das metas especificadas no projeto, como ir além na divulgação do trabalho desenvolvido de forma coletiva e interdisciplinar pela equipe do Núcleo de Extensão CACTUS. 
AVALIAÇÃO MOTORA DE CRIANÇAS ATRAVÉS DO KTK
Authors: Rogeri Luana Andrade , Duarte Maria Eduarda De Oliveira , Dascal Juliana Bayeux
Published: December 2022

A coordenação motora global é uma importante capacidade para realização dos movimentos cotidianos. Um dos instrumentos para avaliar a coordenação motora é o Körperkoordinations test für Kinder (KTK), composto por quatro subtestes motores. O objetivo deste trabalho foi avaliar a coordenação motora global de 27 crianças de quatro a seis anos de idade (média=4,68 e DP=0,49) através do KTK, antes e após uma intervenção motora, no Centro de Educação Infantil Campus UEL. A amostra de crianças foi composta por: crianças frequentadoras do Centro de Educação Infantil Campus UEL (grupo 1), participantes da intervenção motora realizada por um projeto de extensão do Bacharelado em Educação Física, envolvendo habilidades locomotoras, estabilizadoras e de manipulação e por crianças frequentadoras do Centro de Educação Infantil do Hospital Universitário (grupo 2) que não realizaram a intervenção. Os resultados demonstraram diferença significativa entre grupo 1 e 2 somente para o subteste de equilíbrio em marcha ré na trave (p=0,04). Estes resultados demonstraram que a intervenção motora foi suficiente para diferenciar o grupo 1 do grupo 2 apenas para um dos subtestes do KTK. Esses resultados podem ter sido influenciados pela prática motora realizada pelo grupo 1 durante a intervenção motora, assim como pela influência da prática de atividades motoras livres realizadas pelas crianças do grupo 2. 
Entangled Temporalities of Multiverse Narrative: Life’s Lottery by Kim Newman
Authors: Maziarczyk Grzegorz
Published: December 2022

Drawing on recent developments in unnatural narratology, this paper reads entangled temporalities of Kim Newman’s gamebook novel Life’s Lottery in relation to David Deutsch’s quantum theory of the multiverse. The forking narrative structure of the novel, which allows the reader to influence how a particular storyline will develop by choosing from a set of predetermined options, subverts such commonly assumed characteristics of time as unidirectionality and immutability, and undermines classical narratological models of temporal relations between story and discourse. In Life’s Lottery time constantly branches into contradictory timelines, which not only run in parallel but also crisscross one another and loop upon themselves, thus allowing transition between universes and times. Far from a mere exercise in narrative interactivity, a complex multiverse thus created can be construed as a paradoxically verisimilar representation of life’s contingency.
Bionanocomposite Films Based on Chitosan with Bentonite Clay and Polyvinyl Alcohol
Authors: Baimyrza P.A. , Iminova R.S. , Kudaibergenova B.M. , Kairalapova G.Zh.
Published: December 2022

Nanocomposite films based on chitosan nanowhisker (CsW) with ionic and nonorganic polymers were prepared and studied on the swelling and mechanical properties. Сhitosan nanowhiskers were made from α-chitin by using a top-down approach. Ionic polymer polyvinyl alcohol (PVA) and nonorganic bentonite clay (BC) were employed to prepare chitosan nanowhisker bionanocomposite film taking into account their biocompatibility and nontoxicity. Fourier transform infrared spectroscopy analysis, swelling degree measurements and mechanical tests were employed to analyze the influence of significant PVA and bentonite amounts on the film properties. The mechanical strength was found to increase with the rise of the PVA concentration. This is an advantage for producing wound dressing material. The increase in BC concentration in the film resulted in high film stability in water and different mediums and in higher water absorbance than that of CsW/PVA film. However, the highest swelling degree was for a film of CsW itself but the mechanical strength was lower and insufficient to use it for the wound dressing material. Thus, the incorporation of PVA and BC into chitosan nanowhisker can enhance the swelling capacity and mechanical strength.