bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in Pseudomonas aeruginosa
Authors: Spinnato Maria Concetta , Lo Sciuto Alessandra , Mercolino Jessica , Lucidi Massimiliano , Leoni Livia , Rampioni Giordano , Visca Paolo , Imperi Francesco
Published: February 2022

DNA polymerase III (Pol III) is the replicative enzyme in bacteria. It consists of three subcomplexes, the catalytic core, the β clamp, and the clamp loader. While this complex has been thoroughly characterized in the model organism Escherichia coli, much less is known about its functioning and/or its specific properties in other bacteria. Biochemical studies highlighted specific features in the clamp loader subunit ψ of Pseudomonas aeruginosa as compared to its E. coli counterpart, and transposon mutagenesis projects identified the ψ-encoding gene holD among the strictly essential core genes of P. aeruginosa. By generating a P. aeruginosa holD conditional mutant, here we demonstrate that, as previously observed for E. coli holD mutants, HolD-depleted P. aeruginosa cells show strongly decreased growth, induction of the SOS response, and emergence of suppressor mutants at high frequency. However, differently from what was observed in E. coli, the growth of P. aeruginosa cells lacking HolD cannot be rescued by the deletion of genes for specialized DNA polymerases. We also observed that the residual growth of HolD-depleted cells is strictly dependent on homologous recombination functions, suggesting that recombination-mediated rescue of stalled replication forks is crucial to support replication by a ψ-deficient Pol III enzyme in P. aeruginosa.
Prevalence of Intestinal Parasitoses in a Non-Endemic Setting during a 10-Year Period (2011–2020): A Focus on Dientamoeba fragilis
Authors: Calderaro Adriana , Buttrini Mirko , Montecchini Sara , Rossi Sabina , Farina Benedetta , Arcangeletti Maria Cristina , De Conto Flora , Chezzi Carlo
Published: February 2022

Dientamoeba fragilis is a cosmopolitan and neglected protozoan. Although little is known concerning its pathogenicity and its true prevalence worldwide, its role as enteric pathogen is emerging, as the occurrence of dientamoebiasis has increased also in industrialised countries. This study investigated the occurrence and prevalence of intestinal parasites, focusing on D. fragilis in a 10-year period (2011–2020) in a single tertiary-care hospital located in Northern Italy. A statistical evaluation of the correlation between dientamoebiasis and specific signs other than gastrointestinal-related ones was performed. The laboratory diagnosis was performed on 16,275 cases of suspected intestinal parasitoses. Intestinal parasites were detected in 3254 cases, 606 of which were associated to D. fragilis, which represented 18.6% (606/3254) of all the intestinal parasitoses with a 3.7% (606/16,275) prevalence and an increasing trend during the last five years (2011–2015: 2.8% vs. 2016–2020: 4.8%). D. fragilis was commonly detected in foreigners, especially those from developing countries, as well as in children; prevalence was equal in males and females. With regard to the clinical aspect, the only putative sign statistically related to dientamoebiasis was anal pruritus. Despite the controversial epidemiological knowledges on dientamoebiasis, the prevalence of D. fragilis found in this study highlights the need to consider this parasite in any differential diagnosis of gastrointestinal disease.
Cost-Effective Fabrication of Modified Palygorskite-Reinforced Rigid Polyurethane Foam Nanocomposites
Authors: Wang Yulei , Cui Kaibin , Fang Baizeng , Wang Fei
Published: February 2022

Integration of nanoclay minerals into rigid polyurethane foams (RPUFs) is a cost-effective solution to enhance foam’s performance via environmental protection technology. In this work, palygorskite/RPUFs nanocomposites (Pal/RPUFNs) with excellent mechanical properties and thermal stability were prepared via a one-step method, using 4,4’-diphenylmethane diisocyanate and polyether polyol as the starting materials, coupled with Pal modified by silane coupling agent KH570. The effects of the modified Pal on the mechanics, morphology, and thermal properties of the nanocomposites were studied systematically. When the content of the modified Pal was 8 wt% of polyether polyol, the elastic modulus and compressive strength of the Pal/RPUFNs were increased by ca. 131% and 97%, respectively. The scanning electron microscopy images indicated that the addition of the modified Pal significantly decreased the cell diameter of the Pal/RPUFNs. The results of thermogravimetric and derivative thermogravimetry analyses revealed that the addition of the modified Pal increased the thermal weight loss central temperature of the Pal/RPUFNs, showing better thermal stability in comparison with the pure RPUFs. A self-made evaluation device was used to estimate the thermal insulation ability of the Pal/RPUFNs. It was found that the small cell size and uniform cellular structure were keys to improving the thermal insulation performance of the RPUFs. The prepared Pal/RPUFNs are expected to have great potential in the field of building insulation.
Theoretical Calculations and Experiments on the Thermal Properties of Fluorinated Graphene and Its Effects on the Thermal Decomposition of Nitrate Esters
Authors: Meng Saiqin , Fu Xiaolong , Jiang Liping , Shi La , Wang Xu , Liu Xiangyang , Wang Jiangning
Published: February 2022

Fluorinated graphene contains F atoms with high levels of chemical activity, and the application of fluorinated graphene in energetic materials may greatly contribute to the progress of combustion reactions. However, there is a lack of research on the thermal properties of fluorinated graphene and its application on nitrate esters. In this paper, theoretical calculations and experiments were used to study the thermal properties of fluorinated graphene and its application on nitrate esters. The anaerobicity and poor thermal stability of fluorinated graphene were proved by ab initio molecular dynamics (AIMD) calculations and TG-DSC experiments. The ester weakening effect of fluorinated graphene on nitroglycerin was determined via wavefunction analysis, with the greater the fluorination degree, the stronger the ester weakening effect. The existence of fluorinated graphene can significantly increase the heat dissipation of the composites, which was concluded by TG-DSC experiments and TG-DSC-MS-FTIR. The research in this article provides an important reference for the application of fluorinated graphene in energetic materials.
Towards Better CARE for Superficial Fungal Infections: A Consultation Guide for the Community Pharmacy
Authors: Parinyarux Pantira , Thavornwattanayong Wiwat , Soontornpas Cheardchai , Rawangnam Peeranon
Published: February 2022

Superficial fungal infections (SFIs) are among the most common skin diseases worldwide and are common in many parts of Asia. Community pharmacists are well-placed to help identify and manage SFIs. However, effective management may be hindered by a suboptimal consultation process, attributed to the misalignment between consumers’ and pharmacists’ viewpoints. The Fungal CARE (Care, Assess, Recommend, Empower) guide, a patient-centered collaborative framework, was developed to improve pharmacist-led SFI consultations in community pharmacy. A survey on real-world consumer experiences with SFIs provided insights for aligning the Fungal CARE guide with consumer perspectives. To further optimize the guide, community pharmacists were surveyed on their current practice and challenges of managing SFIs, as well as views on the usefulness of the Fungal CARE guide. The pharmacists’ survey indicated that respondents engaged with some but not all of consumers’ top concerns with SFIs, such as emotional and social aspects. Pharmacists identified their greatest challenges as poor compliance with SFI treatment and limited confidence in identifying and/or managing SFIs. Encouragingly, when presented with the Fungal CARE guide, nearly all pharmacists agreed it would be helpful and would use it in practice. Implementing the Fungal CARE guide may help improve pharmacist-led consultations for SFIs and encourage better treatment outcomes.
Recent Advances in 850 nm VCSELs for High-Speed Interconnects
Authors: Cheng Hao-Tien , Yang Yun-Cheng , Liu Te-Hua , Wu Chao-Hsin
Published: February 2022

Vertical-cavity surface-emitting lasers (VCSELs) have made remarkable progress, are being used across a wide range of consumer electronic applications, and have particularly received much attention from the telecom and datacom industries. However, several constraints are thus currently being tackled to improve the device characteristics and modulation formats to meet the various demanding requirements of the future 800 GbE and 1.6 TbE Ethernet standards. This manuscript discusses the device characteristics and the key considerations in the device designs and optimizations. Finally, we elucidate the latest developments and vital features of modern 850 nm VCSELs for high-speed interconnects.
Reduction of Compton Background Noise for X-ray Fluorescence Computed Tomography with Deep Learning
Authors: Feng Peng , Luo Yan , Zhao Ruge , Huang Pan , Li Yonghui , He Peng , Tang Bin , Zhao Xiansheng
Published: February 2022

For bench-top X-ray fluorescence computed tomography (XFCT), the X-ray tube source will bring extreme Compton background noise, resulting in a low signal-to-noise ratio and low contrast detection limit. In this paper, a noise2noise denoising algorithm based on the UNet deep learning network is proposed. The network can use noise image learning to convert the noise image into a clean image. Two sets of phantoms (high concentration Gd phantom and low concentration Bi phantom) are used for scanning to simulate the imaging process under different noise levels and generate the required data set. Additionally, the data set is generated by Geant4 simulation. In the training process, the L1 loss function is used for its good convergence. The image quality is evaluated according to CNR and pixel profile, which shows that our algorithm is better than BM3D, both visually and quantitatively.
Assessing the GHG Emissions and Savings during the Recycling of NMC Lithium-Ion Batteries Used in Electric Vehicles in China
Authors: Zhang Xumei , He Yangyi , Wang Yan , Yan Wei , Subramanian Nachiappan
Published: February 2022

Driven by the global campaign against the dual pressures of environmental pollution and resource exhaustion, the Chinese government has proposed the target of carbon neutrality. On account of this, the increasing number of waste lithium-ion batteries (LIBs) from electric vehicles (EVs) is causing emergent waste-management challenges and it is urgent that we implement an appropriate waste-LIB recycling program, which would bring significant environmental benefits. In order to comprehensively estimate the total greenhouse gas (GHG) emissions from waste-LIB recycling, the GHG savings also need to be taken into account. Based on the requirements of a carbon-neutral target, this study adopted the Intergovernmental Panel on Climate Change (IPCC) method to established a mathematical model for measuring the GHG emissions and GHG savings of waste LIBs and a numerical experiment is presented to verify the model. The results were analyzed and are discussed as follows: (1) To achieve carbon neutrality, the resultant GHG emissions and GHG savings are equal, and the corresponding value is 706.45 kg CO2-eq/t. (2) The influence of the ratio of recovery from different collection centers on the net GHG emissions is relatively weak and the ratio of different processing strategies significantly affects the net GHG emissions. (3) There are three directions including recycling technologies, type of batteries, and environmental pollutants, that warrant investigation in the future research.
Sensor Fault Detection Combined Data Quality Optimization of Energy System for Energy Saving and Emission Reduction
Authors: Guo Yabin , Zhang Zheng , Chen Yu , Li Hongxin , Liu Changhai , Lu Jifu , Li Ruixin
Published: February 2022

China’s “dual carbon” goals, energy conservation and emission reduction in the energy system, have become increasingly important. The sensor fault of an energy system will cause unstable operation and increase energy consumption. Therefore, this study proposes a new sensor fault detection strategy based on the data driven method for energy saving and emission reduction. However, for data-driven models, data quality has a greater impact on model performance. This study innovatively uses five machine learning methods to optimize the energy system operating data. Five machine learning methods include the moving average (MA), Lowess, Loess, Rlowess and Rloess methods. Fault detection performances of different data driven models optimized by different approaches are compared and analyzed. Besides, data outliers and parameter selection of data optimization methods are discussed. The results indicate that the MA method has the best optimization performance when the smoothness degree is level 2. The optimized data fluctuation range is controlled within the range of ±1. The fault detection accuracy rate of the model optimized based on the MA method is increased from 32.51% to 83.96% when the evaporation temperature sensor fault is a 5 °C deviation. However, the data will deviate from the original data trend when the smoothing parameter is set too large. Therefore, the smoothness of the data should not be too large. The approach proposed in this study is of great significance to the energy saving and emission reduction of the energy system.
Catalytic Decomposition of n-C7 Asphaltenes Using Tungsten Oxides–Functionalized SiO2 Nanoparticles in Steam/Air Atmospheres
Authors: Cerón Karen M. , Arias-Madrid Daniela , Gallego Jaime , Medina Oscar E. , Chinchilla Lidia E. , Cortés Farid B. , Franco Camilo A.
Published: February 2022

A wide range of technologies are being developed to increase oil recovery, reserves, and perform in situ upgrading of heavy crude oils. In this study, supported tungsten oxide nanoparticles were synthesized, characterized, and evaluated for adsorption and catalytic performance during wet in situ combustion (6% of steam in the air, in volumetric fraction) of n-C7 asphaltenes. Silica nanoparticles of 30 nm in diameter were synthesized using a sol–gel methodology and functionalized with tungsten oxides, using three different concentrations and calcination temperatures: 1%, 3%, 5% (mass fraction), and 350 °C, 450 °C, and 650 °C, respectively. Equilibrium batch adsorption experiments were carried out at 25 ℃ with model solutions of n-C7 asphaltenes diluted in toluene at concentrations from 100 mg·L−1 to 2000 mg·L−1, and catalytic wet in situ combustion of adsorbed heavy fractions was carried out by thermogravimetric analysis coupled to FT-IR. The results showed improvements of asphaltenes decomposition by the action of the tungsten oxide nanoparticles due to the reduction in the decomposition temperature of the asphaltenes up to 120 °C in comparison with the system in the absence of WOX nanoparticles. Those synthesis parameters, such as temperature and impregnation dosage, play an important role in the adsorptive and catalytic activity of the materials, due to the different WOX–support interactions as were found through XPS. The mixture released during the catalyzed asphaltene decomposition in the wet air atmosphere reveals an increase in light hydrocarbons, methane, and hydrogen content. Hydrogen production was prioritized between 300 and 400 °C where, similarly, the reduction of CO, CH4, and the increase in CO2 content, associated with water–gas shift, and methane reforming reactions occur, respectively. The results show that these catalysts can be used either for in situ upgrading of crude oil, or any application where heavy fractions must be transformed.
Tuning of Model Predictive Controllers Based on Hybrid Optimization
Authors: Giraldo Sergio A. C. , Melo Príamo A. , Secchi Argimiro R.
Published: February 2022

A tuning procedure for a model predictive controller (MPC) is presented for multi-input multi-output systems. The approach consists of two steps based on a hybrid method: the goal attainment method and a variable neighborhood search. In the first step, the weights of the MPC objective function are obtained, minimizing the square error between the closed-loop response of the internal controller model and a predefined desired reference trajectory. In the second step, the integer variables of the problem (prediction and control horizons) are obtained, minimizing the square error between the closed-loop response and an optimal trajectory, aiming a controller with low computational cost and good performance. The proposed method was tested in two benchmark processes using different MPC formulations, showing satisfactory results.
Enhance Teaching-Learning-Based Optimization for Tsallis-Entropy-Based Feature Selection Classification Approach
Authors: Wu Di , Jia Heming , Abualigah Laith , Xing Zhikai , Zheng Rong , Wang Hongyu , Altalhi Maryam
Published: February 2022

Feature selection is an effective method to reduce the number of data features, which boosts classification performance in machine learning. This paper uses the Tsallis-entropy-based feature selection to detect the significant feature. Support Vector Machine (SVM) is adopted as the classifier for classification purposes in this paper. We proposed an enhanced Teaching-Learning-Based Optimization (ETLBO) to optimize the SVM and Tsallis entropy parameters to improve classification accuracy. The adaptive weight strategy and Kent chaotic map are used to enhance the optimal ability of the traditional TLBO. The proposed method aims to avoid the main weaknesses of the original TLBO, which is trapped in local optimal and unbalance between the search mechanisms. Experiments based on 16 classical datasets are selected to test the performance of the ETLBO, and the results are compared with other well-established optimization algorithms. The obtained results illustrate that the proposed method has better performance in classification accuracy.
The Impact of Robotification on the Financial Situation of Microenterprises: Evidence from the Financial Services Sector in Poland
Authors: Cieślukowski Maciej , Garsztka Przemysław , Zyznarska-Dworczak Beata
Published: February 2022

The automation of manufacturing processes as a result of the Fourth Industrial Revolution, rendered faster under the influence of the COVID-19 pandemic, leads to a question as to whether small enterprises, and in particular microenterprises, will still be financially self-sufficient. The literature on the subject so far has not provided an answer to this question, and limited access to financial data concerning microenterprises, as well as data on the robotification of labour in these companies, leads to this problem becoming a research niche. Therefore, this paper aims to assess the attractiveness of the operation of microenterprises that provide financial advisory services in the situation of replacing human labour with robots. For that purpose, we performed a simulation of the state of the microenterprise before and after introducing the robotification of services, taking into account the extra tax on robotification. The findings indicate that anticipating the improvement of financial results following the automation of financial services requires taking into account the replaceability of employees in a particular unit, the form of acquiring a robot and a potential increase in the tax burden (with a tax compensating for the lost state income).
Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum
Authors: Flores Rita , Ramirez Martha , Ayala Luis , Benavides Elizabeth , Xie Fang , Arellano Adrian , Stanko Randy , Garcia Michelle
Published: February 2022

Luteal angiogenesis is regulated by pro-angiogenic hormones including fibroblast growth factor 2 (FGF2) and angiopoietin 1 (Ang1), which are regulated by the adipokine leptin during development. Another adipokine, adiponectin, exhibits an inverse relationship with leptin and has been identified in the CL. Therefore, it is hypothesized that adiponectin will influence pro-angiogenic hormones in the developing porcine CL. Crossbred sows were randomly allocated to one of two days of the estrous cycle, day 5 (D5; n = 4) or day 7 (D7; n = 5) for CL collection. Tissue was processed for immunohistochemical localization of adiponectin receptor 2 (AdipoR2), gene expression of FGF2, Ang1, leptin, AdipoR2, and cell culture for adiponectin treatment. The expression of AdipoR2 tended (p = 0.09) to be higher in D7 lutea and was more prevalently localized to the cell surface of large and small luteal cells than in D5 tissue. Adiponectin influenced (p ≤ 0.05) FGF2, leptin, and AdipoR2 gene expression relative to the dose and day (D5 or D7). Collectively, the evidence supports the supposition that adiponectin influences angiogenic factors in the developing CL.
EFFECT OF USING CLUSTERING TECHNIQUE ON THE STUDENTS ACHIEVEMENT IN WRITING RECOUNT TEXT
Authors: Elista Kiki , Hutabarat Riska Evangelina , Doloksaribu Jefri Ricardo , Bondar Desiana
Published: February 2022

ABSTRACT

This research was conducted to investigate the effect of using clustering techniques on the student achievement in writing recount text. Therefore, an experimental research was conducted to obtain the data, the population of this study were the first school year in the academic year 2019/2020 of SMA DHARMAWANGSA Medan which has two classes consisted of 80 students. They were taken as the sample. 40 students in the experimental group were taught using clustering techniques while the other 40 students in the control group were taught using free writing technique. Writing test was used to acquire to obtain data. The result the data analyzing indicated that there is a large effect of using clustering technique on the students’ achievement in writing recount text since the result tobserved> ttable or 2.568 > 2.06. Thus, the null hypothesis is rejected while the alternate hypothesis is accepted. This the student who are taught using clustering technique could achieve better achievement than students who were taught rewriting technique. Result of data analyzing suggests that teachers should consider the use of clustering techniques in writing recount text to their students.

Keyword : Writing , Recount Text , Clustering Technique
Multilingual Lexical Development : A case of Children of Indonesian Immigrants in Taiwan
Authors: Madinas Madina
Published: February 2022

The number of immigrants increases tremendously in Taiwan. These recent immigrants originate from a variety of ethnicities; some are Han Chinese from Mainland China, others are mainly from Southeast Asian countries, with Vietnamese as the largest group, followed by Indonesians, Thai, and then Philippines. They brought with them their native languages and cultures (Chen,2010). Kuo (2008) found no difference in the lexical development of 2-6- year-old children of Vietnamese mothers and Taiwanese mothers, but children of Indonesian mothers were found to be slower (Kuo, 2015). This study aim to evaluate the the vocabulary size in Indonesian, Mandarin, and Taiwanese for children of Indonesian immigrants in Taiwan. The researcher investigated whether Indonesian mothers in Taiwan with limited Mandarin proficiency are able to provide the kind of input to facilitate their children’s Indonesian, Mandarin and Taiwanese acquisition or not.This study used Peabody Picture Vocabulary Test to assess their lexical development in Indonesian and Mandarin. The Taiwanese language measure tool is an application developed by Kuo (2017). This study revealed that the vocabulary score of Indonesian score were found to be lower than Mandarin and Taiwanese score and Mandarin score higher than Taiwanese score. The factors related to children’s lexical development were also investigated no correlation between Indonesian mother’s with their children in Indonesian language, because most of them communicate with their limited Mandarin or Taiwanese. Finally, this research should help people to have a better understanding about the phenomenon of multilingual family, where multilingual has become common in the society.

 

Keyword : Multilingualism, lexical development, immigrant children, vocabulary size
STUDENTS’ ABILITY IN IDENTIFYING INTERROGATIVE SENTENCES THROUGH CONVERSATION TEXT
Authors: Saragi Sendy Fernando , Tamba Meysi , Delvina Yosa , Purba Resperdiana
Published: February 2022

ABSTRACT

 

The research is entitled an analysis of student's ability in identifying interrogative sentences through conversation text in SMK PendidikanSiapMandiri. The purpose of the research is to analyze data in detail to see how far the students' understanding of using interrogative sentences in conversational texts was. In order, it will produce the right of fixed data. This method of research uses conversation text. By using qualitative data, collecting data in using a written test by doing two tests. The results showed that on the first test only a few students get a score of 75, it is estimated that only 30% of students got the score criteria. However, in the second test, the researcher gives another explanation to the students to better understand how to identify interrogative sentences. And the result is that the student's ability has increased by 50%, many students have successfully met the score criteria, namely at least 75. So, the result of the research shows that the analysis of students' ability in identifying interrogative sentences is still lacking. Therefore, the conclusion is they can improve their abilities even better by learning more about an interrogative sentence.

Keywords: Conversation text, Interrogative Sentences, Writing.
PEMBUATAN VIDEO PEMBELAJARAN MELALUI METODE PROJECT BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN KOMPETENSI GURU DI SMP NANYANG ZHI HUI DIMASA PANDEMI COVID-19
Authors: Sinaga Artha Lina
Published: February 2022

Tujuan penelitian ini adalah Untuk mengobservasi dan mengevaluasi video pembelajaran melalui metode PBL dapat meningkatkan kompetensi guru di SMP Nanyang Zhi Hui Medan di masa Pandemi Covid-19. Untuk mengobservasi dan mengevaluasi apakah metode PBL dapat meningkatkan kompetensi guru di SMP Nanyang Zhi Hui Medan di masa Pandemi Covid-19. Untuk mengobservasi dan mengevaluasi video pembelajaran melalui metode PBL dapat meningkatkan kompetensi guru di SMP Nanyang Zhi Hui Medan di masa Pandemi Covid-19. Untuk mengobservasi dan mengevaluasi apakah metode PBL dapat meningkatkan kompetensi guru di SMP Nanyang Zhi Hui Medan di masa Pandemi Covid-19. Pembuatan video pembelajaran melalui metode PBL dapat meningkatkan kompetensi guru di SMP Nanyang Zhi Hui Medan di masa Pandemi Covid-19.

 

Kata Kunci: Pembuatan Video Project Based Learning Pandemic
Eating Habits in the Aasarakkovai
Authors: S Little Flower
Published: February 2022

Human life is founded on virtue and common good of the society. Life is not commendable when one chooses to live recklessly just as he/she wants. One of the primary facets of Literatures of Ethics in Tamil is to foster meaningful values and adhere to them in life. Food customs indicate certain cultural formalities to be maintained as practice. This paper/thesis deals with a system of food customs that energize, develop cell-systems and cause good functioning of bodily organs as oriented by “Aasarakovai”.
The State of Microbiocinosis in Patients with Cystic Lesions of the Maxillary Sinuses
Authors: Насретдинова М.Т. , Хайитов А.А. , Нормурадов Н.А.
Published: February 2022

Введение. Проблема выбора своевременной диагностики и адекватного лечения хронических кистозных верхнечелюстных синуситов остается актуальной в современной оториноларингологии. Своевременное диагностирование и лечение кистозных процессов околоносовых синусов носа является одной из приоритетных задач оториноларингологии вследствие роста заболеваемости данной патологией. Цель. Изучение спектра микробного пейзажа верхнечелюстных синусов у пациентов с хроническим кистозным верхнечелюстным синуситом. Материалы и методы. Обследовано 35 человек с диагнозом «хронический кистозный верхнечелюстной синусит», которым проведено микробиологическое исследование операционного материала из верхнечелюстного синуса. Рост микрофлоры выявлен у 32 (92,5%), из них у 3 (3,75%) - дрожжеподобные грибы рода Candida, стерильные посевы только у 3 (8,5%) пациентов, аэробные микроорганизмы преобладали над анаэробными. Результаты. Результат нашего исследования говорит об уровне изменения нормального микробного пейзажа верхнечелюстных синусов, и определение значения уровня дисбиоза верхнечелюстных синусов рекомендовано для оценки тяжести течения патологического процесса. Заключение. Определение значения уровня дисбиоза верхнечелюстных синусов в качестве тест-контроля рекомендовано для оценки характера течения патологического процесса.

Introduction. The problem of choosing timely diagnostics and adequate treatment of chronic cystic sinusitis remains relevant in modern otorhinolaryngology. Timely diagnostics and treatment of cystic processes of the paranasal sinus is one of the priority tasks of otorhinolaryngology due to increase of the incidence of this pathology. Purpose. The aim of research was to study the spectrum of the microbial landscape of the maxillary sinuses in patients with chronic cystic maxillary sinusitis. Materials and methods. A total of 35 people were examined with the diagnosis of chronic cystic sinusitis, who underwent a microbiological study of surgical material from the maxillary sinus. Microflora growth was detected in 32 (92.5%) patients, of which in 3 cases (3.75%), the yeast-like fungi of the genus Candida were observed; sterile cultures were revealed in only 3 (8.5%) patients; aerobic microorganisms prevailed over anaerobic ones. Results. The result of our study indicates the level of changes of the normal microbial landscape of the maxillary sinuses. Determination of the level of dysbiosis of the maxillary sinuses is recommended for assessing the severity of the pathological process. Conclusion. Determination of the level of dysbiosis of the maxillary sinuses as a test control is recommended to assess the nature of the course of the pathological process.
Receptor Effects and Therapeutic Spectrum of Mirtazapine
Authors: Ассанович М.А.
Published: February 2022

Миртазапин - антидепрессант двойного действия, действующий как на норадренергическую, так и серотонинергическую нейротрансмиссию посредством антагонизма к альфа-2 рецепторам. Препарат имеет уникальный среди других антидепрессантов фармакологический профиль. Антидепрессивный эффект проявляется при умеренной - тяжелой депрессии. Обнаруживает анксиолитический эффект. Антагонизм к 5-HT2-рецепторам обусловливает показания к назначению препарата при тревоге, беспокойстве и нарушениях сна. Антагонизм к5-HT3-рецепторам определяет противорвотный эффект и подавление чрезмерного высвобождения мезолимбического дофамина. Токсические эффекты значительно менее выражены по сравнению с трициклическими антидепрессантами. Отсутствуют лекарственные взаимодействия и серотониновый синдром. Терапию миртазапином следует начинать с дозы 15 мг в день с последующим увеличением до терапевтической. Доза препарата, превышающая 30- 45 мг в день, не прибавляет существенного терапевтического эффекта. Препарат следует назначать вечером, учитывая седативный и снотворный эффект в начальном периоде терапии. Миртазапин может назначаться в виде монотерапии или в сочетании с другими препаратами. Наиболее эффективной комбинацией в случае терапии резистентной депрессии представляется сочетание миртазапина и венлафаксина. Миртазапин может эффективно применяться в лечении функциональных расстройств желудочно-кишечного тракта, сопровождающихся тошнотой, рвотой, болями и диареей. Снижает риск осложнений и смерти при COVID-19.

Mirtazapine is a dual-acting antidepressant that acts on both noradrenergic and serotonergicneurotransmission through alpha-2 receptor antagonism. It has a unique pharmacological profileamong other antidepressants. Antidepressant effect appears in moderate to severe depression. Italso shows anxiolytic effect. Antagonism to 5-HT3-receptors provides indications for prescribingthe antidepressant for anxiety and sleep disorders. Antagonism to 5-HT3-receptors determines theantiemetic effect and suppression of excessive release of mesolimbic dopamine. The toxic effects aresignificantly less pronounced if compared to tricyclic antidepressants. There are no drug interactionsand serotonin syndrome. Therapy with mirtazapine should be started with the dose of 15 mg perday followed by the increase to therapeutic dose. The dose exceeding 30–45 mg per day does notadd a significant therapeutic effect. The antidepressant should be administered in the evening,taking into account sedative and hypnotic effect in the initial period of therapy. Mirtazapine can begiven as monotherapy or in combination with other medicines. The most effective combination fortreatment of resistant depression appears to be the combination of mirtazapine and venlafaxine.Mirtazapine can be effectively used in treatment of functional disorders of the gastrointestinal tract,accompanied by nausea, vomiting, pain and diarrhea. It reduces the risk of complications and deathfrom COVID-19.
Interictal Dysphoric Disorder (IDD) in Epilepsy Patients
Authors: Дубенко А.Е. , Коростий В.И.
Published: February 2022

В первой половине XX века дисфорические эпизоды у пациентов с эпилепсией были описаны основоположником нозологического подхода в психиатрии E. Kraepelin. Несмотря на то что симптомы дисфории могут возникать как пре-, так и постиктально, данные состояния возникают без какой-либо связи с эпилептическими приступами. Интериктальное дисфорическое расстройство (ИДР) - это специфическое аффективно-соматоформное расстройство, наиболее часто встречающееся у пациентов с фармакорезистентной эпилепсией, в особенности при локализации эпилептического очага в височной доле. Выделяют 8 ключевых симптомов. При тотальном тестировании пациентов с эпилепсией ИДР можно диагностировать у 50,7% пациентов с эпилепсией, а отдельные симптомы обнаруживаются почти у всех пациентов. Для диагностики ИДР и его дифференциации от перииктальных психических нарушений был предложен опросник интериктального дисфорического расстройства (IDDI). Нет четких рекомендаций по лечению ИДР. Рассмотрены вопросы немедикаментозного и медикаментозного лечения ИДР.

In the first half of the XX century, dysphoric episodes in patients with epilepsy were described by thefounder of the nosological approach in psychiatry – E. Kraepelin. Despite the fact that the symptomsof dysphoria can occur both pre-and postictally, these conditions occur without any connectionwith epileptic seizures.Interictal dysphoric disorder (IDD) is a specific affective – somatoform disorder that is most commonin patients with pharmacoresistant epilepsy, especially when the epileptic focus is localized in thetemporal lobe. There are 8 key symptoms. With total testing of patients with epilepsy, IDD canbe diagnosed in 50.7% of patients with epilepsy, and individual symptoms are found in almostall patients. The Interictal Dysphoric Disorder Inventory (IDDI) questionnaire was proposed forthe diagnosis of IDR and its differentiation from periictal mental disorders. There are no clearrecommendations for the treatment of IDD. The issues of non-drug and drug treatment of IDD areconsidered.
Diagnostics and Stenting of Coronary Arteries Aneurysms: Treatment of Myocardial Ischemia or Prevention of Complications?
Authors: Левчишина Е.В. , Аксенов Е.В.
Published: February 2022

Цель. Представить 16-летний опыт диагностики и лечения аневризм коронарных артерий (АКА) в одном кардиохирургическом центре. Материалы и методы. При написании статьи были использованы данные из медицинских карт и листов назначений стационарных пациентов с АКА, результаты коронарной ангиографии и записи операций. Результаты. За период с 2000 по 2016 г. из 3846 стентирований коронарных артерий шесть было выполнено по поводу АКА. Терапия АКА проводилась методом имплантации стентграфтов. Все шесть клинических случаев детально описаны, предоставлены данные литературы о классификации, частоте встречаемости, симптоматике и осложнениях, ассоциированных с данной патологией. Заключение. АКА в некоторых случаях ухудшают прогноз пациентов, особенно в сочетании с атеросклеротическими поражениями коронарного русла. Наличие АКА повышает риск тромбообразования в области коронарных артерий. Пациенты с АКА требуют более тщательного наблюдения с целью раннего выявления и лечения атеросклеротических стенозов коронарных артерий. Стентирование аневризм коронарных артерий с использованием стент-графтов является адекватным методом профилактики разрыва аневризм.

Purpose. To present the 16-year experience of diagnostics and treatment of the coronary artery aneurysms (CAA) in a single cardiac surgery center. Materials and methods. The data on the patients with CAA was collected from the hospital records, coronary angiography, and procedure recordings. Results. 3846 coronary artery stentings were carried out in our center between 2000 and 2016, including 6 procedures performed due to CAA. Each CAA case was treated through stent-graft implantation. We describe all six cases in detail and provide the literature data on classification, epidemiology, clinical presentation, and complications associated with this condition. Conclusion. Coronary arteries aneurysms make a patient’s prognosis worse, especially in combination with coronary atherosclerotic lesions. The presence of CAA increases the risk of coronary arteries thrombosis. Patients with CAA require more careful observation for early detection and treatment of atherosclerotic lesions of coronary arteries. Stent-graft implantation is the best preventive method for CAA rupture.
Treatment of Patients with Refractory/Recurrent Multiple Myeloma in Real Clinical Practice
Authors: Искров И.А. , Кошкевич В.В. , Лендина И.Ю. , Усс Е.В. , Суворов Д.И. , Усс А.Л.
Published: February 2022

Внедрение в терапию множественной миеломы иммуномодулирующих препаратов, моноклональных антител и ингибиторов протеасом позволило значительно увеличить медиану общей выживаемости за последние 20 лет с 3-4 до 7-8 лет. Практически у всех пациентов с ММчерез разные промежутки времени наступает рецидив. Длительность ремиссий после рецидивов сокращается с каждым циклом, особый интерес представляет персонифицированный выбор тактики лечения рецидивирующей и рефрактерной множественной миеломы. При этом учитывается множество факторов: предшествующая терапия (режим индукции, количество линий терапии), агрессивность рецидива, состояние пациента (коморбидность) и т. д. Большинство режимов, использующихся в терапии рецидивов ММ, включают в себя новые препараты с отсутствием перекрестной резистентности к препаратам, используемым в индукции. Приводится описание клинического случая пациента с рецидивирующей множественной миеломой и оценкой эффективности различных режимов терапии. Также описан собственный опыт лечения рецидивирующей/рефрактерной множественной миеломы современными ингибиторами протеасом с оценкой полученных результатов.

The introduction of immunomodulatory drugs, monoclonal antibodies, and proteasome inhibitors into the therapy of multiple myeloma significantly increased the median of overall survival over the past 20 years from 3-4 to 7-8 years. Almost all patients with MM relapse in different intervals. The duration of remission after relapses decreases with each cycle. The personalized choice of tactics for treatment of recurrent and refractory multiple myeloma is of particular interest. This takes into account many factors: previous therapy (induction mode, number of therapy lines), aggressiveness of relapse, patient’s condition (comorbidity), etc. Most of the regimens used in the treatment of recurrent MM include new drugs without cross-resistance to the drugs used in induction. The description of a clinical case in a patient with recurrent multiple myeloma and assessment of the effectiveness of various therapy regimens are given. We also describe our own experience in the treatment of recurrent/refractory multiple myeloma with modern proteasome inhibitors with assessment of the results.
El juego grupal como propuesta identificatoria en la psicosis infantil
Authors: Hetzer Juan Pablo
Published: February 2022

Este artículo expone la experiencia de un abordaje de la psicosis infantil a partir de una estrategia que articula el trabajo clínico en el ámbito del consultorio externo de un hospital público con un dispositivo de juego grupal con pelota al aire libre. Lo que atraviesa esta articulación es el juego como propuesta identificatoria. La invención de este dispositivo clínico grupal y las intervenciones realizadas que se presentan en este trabajo, se inscriben en un proceso de desinstitucionalización de lógicas, de concepciones y prácticas que objetalizaron a les niñes a partir de una disociación histórica entre infancia y juego. Esta disociación revela un punto donde la institución hospitalaria hacía totalidad.
Paciente, sujeto, usuario La palabra de la ley en la constitución del campo de la Salud Mental
Authors: Moreno Tatiana
Published: February 2022

El presente trabajo se propone indagar los modos en que distintas leyes de salud mental constituyen el campo al que hacen referencia. Partimos de suponer el carácter performativo de toda ley, en tanto el lenguaje constituye “lo real” al nombrarlo, para luego analizar en particular algunos aspectos de cada una de las tres leyes seleccionadas, dos de carácter provincial (provincia de San Juan, ley Nº 6976 y provincia de Santa Fe, ley N° 10772) y la ley Nacional de Salud Mental y Adicciones N° 26657. En un tercer momento se presenta un breve recorrido que nos permite poner en cuestión a “la locura” como objeto natural para abordarla, en cambio, como una categoría construida por discursos atravesados por la historia y la cultura.
Autonomía en salud mental:
Authors: Garay Magalí Claros
Published: February 2022

Este trabajo analiza los sentidos sobre la autonomía, que se construyen en prácticas sustitutivas, a partir del encuentro con sus trabajadores. Asimismo, recoge algunas referencias teóricas que abonan al sentido que adquiere el término para el campo de la salud mental. La inquietud fundamental se orienta a conocer y analizar a qué se hace referencia cuando se habla de autonomía en salud mental y cuáles son los indicadores que se construyen al interior del campo. Por la naturaleza del tema se utiliza un abordaje cualitativo y se realizan entrevistas semidirigidas a informantes clave, de las cuales se extraen los ejes de sentido que son analizados. Los mismos implican un deslizamiento de la definición al sentido, pasando por la idealización de la categoría y su relación con la noción de independencia. A partir de los relatos y las experiencias clínicas brindadas se ubica el valor subjetivante que supone la autonomía en relación a la capacidad de decisión y la construcción de lazos sociales en la comunidad. En suma, este trabajo posibilita recuperar la dimensión de la autonomía como un elemento nodal para las prácticas sustitutivas, teniendo en cuenta que sus trabajadores elaboran una forma particular de comprenderla y operar con ella. De este modo, se confecciona una acepción del término que hace a la especificidad de un campo, y toma elementos de la perspectiva psicoanalítica.
Sistem Informasi Penjualan Buku Berbasis Web Pada Toko Buku Monster Book Kabupaten Mamuju
Authors: Nilmawati Nilmawati , Assidiq Muhammad , Syarli Syarli
Published: February 2022

E-Commerce adalah Kegiatan jual beli barang/jasa atau transmisi dana/data melalui jaringan elektronik, terutama internet. Dengan perkembangan teknologi informasi dan software, hal ini membuat transaksi konvensional menjadi mungkin untuk dilakukan secara elektronik. Adapun tujuan dari dari  penelitian ini adalah merancang system informasi penjualan berbasis website terkait belum adanya penunjang yang dapat mendukung komunikasi antara pengunjung dengan pihak took monster book. Pada sistem ini admin melakukan penginputan judul buku yang tersedia beserta harga yang di proses di database dan hasilnya outputnya berupa informasi buku  dan harga yang tersedia di website sedangakan pengunjung melakukan pemesanan di website yang telah disediakan kemudian admin akan menerima berapa jumlah pesanan buku yang  telah dikirim oleh pengunjung yang akan membeli buku yang tersedia selanjtnya admin memiliki akses masuk di situs web yang disediakan untuk memberi konfirmasi kepada pengunjung apakah pemesanan diterima atau tidak. Hasil penelitian ini adalah sebuah aplikasi Sistem Informasi Penjualan Buku Berbasis Web Pada Toko Buku Monster Book Mamuju menggunakan bahasa pemrograman php dan html.
SISTEM REPOSITORY SKRIPSI DENGAN METODE COSINE SIMILARITY BERBASIS WEB
Authors: Norman Norman , Sari Cipta Riang , Qashlim Akhmad
Published: February 2022

Sistem Repository merupakan media penyimpanan yang terjaga keamanannya terhadap dokumen dan data penelitian. Hal ini menjadi mediator antara peneliti dengan sistem berupa kemudahan bagi peneliti untuk menelusur kembali karya ilmiah yang pernah dihasilkan dimanapun mereka berada. Sistem repository diperlukan untuk memudahkan mahasiswa(i) dalam pencarian dokumen-dokumen secara cepat dan efesien di Fakultas Ilmu Komputer.Sistem Sistem repository ini dibuat menggunakanMetode cosine similaiy sertamenggunakan PHP ,XAMPP dan MYSQL sebagai web Sistem server.Penelitian ini di laksanakan di Universitas ALL-Asyariah Mandar dari bulan februari hingga maret 2020.Dari penelitian ini di hasilkan suatu Sistem repository yang menyajikan iformasi data skripsi dan di harapkan dapat memberi kemudahan bagi peneliti untuk menelusuri kembali karya lmiah yang pernah di hasilkan.
SPK PEMILIHAN DOSEN TERBAIK MENGGUNAKAN METODE SAW BERBASIS WEB PADA UNIVERSITAS AL ASYARIAH MANDAR.
Authors: Nurhidayat Muhammad , Assidiq Muhammad , Qashlim Akhmad
Published: February 2022

Proses evaluasi dan penilaian yang coba diangkat dalam penelitian ini nantinya akan dibuktikan dengan cara menyimpulkan hasil jawaban kuesioner dari mahasiswa,dosen sejawat dan pihak pimpinan yang merupakan standarisasi penilaian dosen berdasarkan beban kerja dosen (BKD). Proses evaluasi dan penilaian juga berdasarkan Tri Dharma perguruan tinggi yang di lakukan oleh setiap dosen selama 1 tahun akademik. Tujuan penelitian ini adalah membuat rancangan sistem pendukung keputusan pemilihan dosen terbaik pada universitas al asyariah mandar berdasarkan kriteria penilaian yang dilakukan dilingkup universitas, agar dapat menjadi bahan rekomendasi kepada pihak pimpinan dalam pengambilan keputusan untuk menentukan penyandang predikat dosen terbaik setiap tahunnya. Tipe penelitian yang digunakan adalah penelititan rekayaasa perangkat lunak dengan menggunakan bahasa pemprograman PHP. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah Teknik pengumpulan data kuesioner, observasi, studi pustaka, dan wawancara. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik penelitian kuantitatif.Dengan menggunakan Sistem Pendukung Keputusan Pemilihan Dosen Terbaik berbasis Web, maka akan didapatkan informasi hasil perengkingan dosen terbaik. Hasil perengkingan nantinya dapat menjadi bahan rekomendasi bagi pihak pimpinan dalam pengambilan keputusan penyandang predikat dosen terbaik setiap tahunnya.penulisan skripsi ini dilakukan pada bulan Februari sampai dengan bulan April 2020 dengan lokasi penelitian pada Universitas Al Asyariah Mandar.