bluuebunny/crossref_metadata_2025 huggingface dataset:
ДИАГРАММА ИСИКАВЫ КАК МЕТОД АНАЛИЗА БИЗНЕС-ПРОЦЕССА
Authors: Репина Ю. А. , Жакина М. В.
Published: February 2024

В статье рассматривается применение диаграммы Исикавы с целью анализа бизнес-процесса «Подготовка к производству», представлены результаты аудита бизнес-процесса, рекомендации по его совершенствованию и системы менеджмента качества предприятия.
АНАЛИЗ ЭФФЕКТИВНОСТИ БИЗНЕС-ПРОЦЕССОВ НА СКЛАДЕ АО «ТАНДЕР»
Authors: Репина Ю. А.
Published: February 2024

Неотъемлемой частью деятельности любого предприятия является логистика. Для современного бизнеса управление логистикой это инструмент для снижения затрат, обеспечения качества товаров и услуг по его хранению, упаковке и доставке в оптимальные сроки. Логистика складирования позволяет максимально использовать возможности информационных систем; снижать издержки за счет минимизация маршрутов внутри складской перевозки; эффективное использовать пространство; рационально планировать и совершенствовать работу на складе.
ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ МЕРОПРИЯТИЙ ПО ПРИМЕНЕНИЮ
ТЕХНОСФЕРНОЙ БЕЗОПАСНОСТИ
Authors: Рустамова А. И. , Антонов А С. А. , Иноходцева И. А.
Published: February 2024

Рассматривается сущность техносферной безопасности государства, его роль в жизнедеятельности человека, а также комплексная работа государственных органов и промышленных предприятий, который стремятся снизить формировать вероятность наступления чрезвычайных ситуаций. Были определены функциональные обязанности, а также меры, применяемые в рамках техносферной безопасности, которые и определяют эффективность данной системы в целом.
ПРАКТИКА ВНЕДРЕНИЯ СИСТЕМЫ МЕНЕДЖМЕНТА КАЧЕСТВА В МЕДИЦИНСКОЙ ОРГАНИЗАЦИИ
Authors: Антонова И. И. , Мухаметханова Н. И. , Яруллин Э. Ш. , Шигапов И. Ф.
Published: February 2024

В статье проанализирована эффективность и преимущества внедрения система менеджмента качества в медицинского организации на примере центральных районных больниц Республики Татарстан.
ДИАГНОСТИКА И МОНИТОРИНГ ПРОИЗВОДСТВЕННОЙ СИСТЕМЫ ПРЕДПРИЯТИЯ
Authors: Фролова И. И. , Хафизов А. Н.
Published: February 2024

В статье представлены результаты анализа производственной системы машиностроительного предприятия, а также предложены рекомендации по совершенствованию диагностики и мониторинга производственной системы.
ОБЕСПЕЧЕНИЕ УСТОЙЧИВОСТИ ОРГАНИЗАЦИИ ПУТЕМ ПОВЫШЕНИЯ КАЧЕСТВА БИЗНЕС-ПРОЦЕССОВ
Authors: Хадиева А. Т. , Антонов В. С. , Акмурзина Л. Ф.
Published: February 2024

Данная статья рассматривает вопросы обеспечения устойчивости промышленности и бизнеса с помощью повышения качества продукции и услуг, а также формирования эффективных бизнес-процессов. В условиях конкуренции и нестабильности экономической ситуации, повышение качества продукции и услуг является ключевым фактором привлечения и удержания клиентов, укрепления репутации и повышения конкурентоспособности. Также обсуждается необходимость создания эффективных бизнес-процессов, которые позволяют оптимизировать деятельность компании, снижать издержки и обеспечивать предсказуемость и стабильность. Взаимосвязь между качеством продукции, услуг и бизнес-процессами подчеркивается в контексте общей стратегии достижения устойчивого развития и успеха.
ТЕХНОЛОГИЧЕСКИЙ СУВЕРЕНИТЕТ –КЛЮЧ К НАЦИОНАЛЬНОЙ БЕЗОПАСНОСТИ
Authors: Чхутиашвили Л. В.
Published: February 2024

В статье рассматривается современное положение российской экономики. Как происходит импортозамещение в условиях санкций против России, что подразумевает собой технологический суверенитет и как Россия его добивается. Действия государства, направленные на развитие экономики России прослеживаются в решении насущных проблем и составление прогнозов на перспективу. Именно комплекс рассмотренных выше мер при грамотной совместной работе поспособствует развитию экономики Российской Федерации на современном этапе.
ИНФОРМАЦИЯ КАК ХАРАКТЕРИСТИКА КАЧЕСТВА БИЗНЕС-ПРОЦЕССОВ РОССИЙСКОГО ПРЕДПРИНИМАТЕЛЬСТВА
Authors: Шафранская Ч. Я.
Published: February 2024

В статье раскрывается суть бизнес-процесса, индикаторов качества и цифровизации и их влияния на развитие российского предпринимательства в сфере управления качеством.
ЦИФРОВИЗАЦИЯ И БИЗНЕС-МОДЕЛИ СИСТЕМЫ МЕНЕДЖМЕНТА
РОССИЙСКОГО ПРЕДПРИНИМАТЕЛЬСТВА
Authors: Шафранская Ч. Я.
Published: February 2024

В статье рассматриваются различные виды бизнес-моделей. Связь бизнес-моделей и реального бизнеса. Раскрывается роль цифровизации в развитии предпринимательства.
ПРЕДПРИНИМАТЕЛЬСТВО КАК РЕСУРС КАЧЕСТВЕННОГО ИМПОРТОЗАМЕЩЕНИЯ В НЕСТАБИЛЬНЫХ ЭКОНОМИЧЕСКИХ УСЛОВИЯХ
Authors: Шафранская Ч. Я.
Published: February 2024

В статье рассматривается влияние качественного импортозамещения в санкционных нестабильных экономических условиях на предпринимательский сектор, описывается актуальное состояние предпринимательской деятельности в новых условиях функционирования, раскрываются проблемы бизнеса и приоритетные направления развития в условиях политики импортозамещения.
К ВОПРОСУ ОБ ОРГАНИЗАЦИИ СТРАТЕГИЧЕСКОГО УПРАВЛЕНИЯ
ИННОВАЦИОННО-ТЕХНОЛОГИЧЕСКИМ РАЗВИТИЕМ В РОССИИ
Authors: Абзалилова Л. Р.
Published: February 2024

В статье на основе анализа накопленного в 2014–2023 годы опыта в России в области инновационно-технологического развития выделено три группы реализуемых стратегий. Сделан вывод о реализации в стране комбинированного подхода к управлению, сочетающего в себе две теоретические модели: технологического разрыва и технологического рывка.
МАРКЕТИНГ ОРГАНИЗАЦИЙ В УСЛОВИЯХ ЦИРКУЛЯРНОЙ ЭКОНОМИКИ
Authors: Безуглая В. А.
Published: February 2024

В публикации рассмотрено понятие циркулярной экономики, основные принципы и преимущества ее активного развития в современном обществе. Изучено влияние перехода к циркулярной экономике на формирование маркетинговых стратегий организаций. Определены новые возможности и приоритетные направления развития в маркетинге.
ИМПОРТОЗАМЕЩЕНИЕ КАК ОСНОВНОЙ ИНСТРУМЕНТ РАЗВИТИЯ ПРЕДПРИЯТИЙ ПИЩЕВОЙ ПРОМЫШЛЕННОСТИ
Authors: Герасимова А. Е. , Соколенко Е. В. , Григорьянц А. А.
Published: February 2024

Рассмотрены основные направления политики импортозамещения в России; выявлены проблемы развития приоритетных и стратегически важных отраслей экономики, обострившиеся на фоне санкционного противостояния недружественных государств; проанализировано текущее состояние продовольственного комплекса РФ в условиях внешнеторговой изоляции страны; идентифицированы основные трудности, препятствующие достижению импортонезависимости российских предприятий в сфере пищевой промышленности; обоснована необходимость технико-технологической модернизации отечественных пищевых производств.
БЕЗОПАСНОСТЬ, КАЧЕСТВО И ЭРГОНОМИКА ПРИМЕНИТЕЛЬНО
К МЕДИЦИНЕ
Authors: Гросси Ф. К.
Published: February 2024

В области медицины и организации медицинских учреждений крайне важно уделять приоритетное внимание безопасности и качеству, которые служат основой для эргономических исследований и вмешательств. Этот подход основан на потребностях человека и способствует непрерывным инновациям.
ИННОВАЦИОННЫЕ ФОРМЫ РАБОТЫ С МОЛОДЕЖНОЙ АУДИТОРИЕЙ
Authors: Егиазарян Н. В.
Published: February 2024

Представленная работа посвящена вопросам работы с молодежной аудиторией и ее специфическими особенностями. Рассматривается роль преподавателей в образовательном процессе, в становлении личности обучающихся и выборе ими будущей профессии.
Effect of Cr-solidified/stabilized Water-quenched Slag on Strength and Leaching Characteristics of Blast Furnace Slag Cement
Authors: Zhao Zheng , Zhang Yanling , Wu Shaowen , Zhang Shuai , Yuan Fang
Published: February 2024

This article presents an original study into the feasibility of using blast furnace slag and stainless steel pickling sludge to produce solidified/stabilized Cr slag micro-powder and its application in slag cement. A process route for utilizing blast furnace slag to dispose of pickling sludge online is proposed. The characteristics of Cr-solidified/stabilized water-quenched slag and composite slag cement are characterized, and the feasibility and economic viability of preparing mineral slag micro-powder are evaluated. The results demonstrate that the addition of sludge increases the grindability of water-quenched slag, with a specific surface area increasing from 971m²/kg to 1125m²/kg, and a glass phase content reaching 99%. Chromium in the mineral slag micro-powder exists either in solid solution within the glass network structure or in the form of spinel phase, significantly reducing its leaching toxicity. The prepared composite slag cement, with BP5 sample as the highest compression strength of 51.4MPa, achieves an activity index of S105. SEM analysis shows that the cement mortar samples cured for 28 days form a dense gel-like structure with good hydration performance. The leaching concentration of Cr in BP5 is the lowest, only 11.6 ug/L. The evaluation of process feasibility and economics shows that the solidified Cr slag powder prepared by large-scale online disposal of sludge is feasible. It can not only bring direct economic benefits, but also eliminate the environmental threats caused by hazardous waste, reduce energy consumption, and indirectly Reduce carbon emissions.
Reassembly of ground-dwelling ant communities in reforestation plots in SW Costa Rica
Authors: Karolak Marta , Fiedler Konrad
Published: February 2024

Due to agriculture and logging Costa Rica has lost many primary forests, making reforestation an important task. In order to judge the progress of reforestation it is important to follow the re-assembly of organismal communitiess within the restored habitats. The COBIGA project near La Gamba, in the Golfo Dulce region of Costa Rica, aims at reforestation of lowland sites with native tree species. Ants, as ubiquitous and highly abundant terrestrial organisms, have a substantial influence on tropical ecosystems. Their multiple roles include scavenging, predation, herbivory, and mutualistic interactions. We examined ant community responses, aiming to reveal the status of community regeneration and functional integrity. We compared the composition and diversity of ant assemblages at reforestation sites of three different ages (two, eight and ten years old) with an old-growth forest as a reference site. Offering canned tuna fish on ground level along replicated transects, we altogether observed 43 ant species representing six functional groups during two months of sampling. Most observed ant species were omnivorous but old-growth forest harbored a substantial number of other functional groups like generalized predators, arboreal predators, and arboreal omnivores. In contrast, the youngest reforestation site harboured a severely impoverished ant assemblage comprising mostly generalized polygynous and polydomous ant species from lower trophic levels. Within-site heterogeneity of ant assemblages increased from the youngest to the oldest forest. On top of that, our results show the importance of monitoring the progress of forest recovery to avoid the spread of invasive species into primary habitats.
Crocin improves cognitive impairment in LPS-treated rats by anti-apoptotic, anti-inflammatory and antioxidant activities
Authors: Dastan Maryam , Rajaei Ziba , Sharifi Mohammadreza , Salehi Hossein
Published: February 2024

Brain inflammation and oxidative stress play a critical role in the neuronal apoptosis and memory dysfunction in Alzheimer’s disease. Crocin is a natural carotenoid present in the stigma of saffron which possesses radical scavenging, anti-inflammatory, and anti-apoptotic properties. The present study examined the protective impact of crocin on neuronal apoptosis, oxidative stress, neuroinflammation and memory deficits induced by lipopolysaccharide (LPS) in rats. Wistar rats received crocin at a dose of 100 mg/kg for 12 days. Besides, LPS (1 mg/kg, ip) was injected on days 8–12. Spatial memory was evaluated in the Morris water maze, two hours after LPS injection on days 8–12. Gene expression of nuclear factor (NF)-κB, tumor necrosis factor-α (TNF-α), caspase 3 and lipid peroxidation was assessed in the hippocampal homogenates at the end of behavioral test. Histopathological changes in the hippocampus and cerebral cortex was evaluated using H&E staining. According to results, administration of LPS caused spatial memory dysfunction accompanied by upregulation of mRNA expression of NF-κB, TNF-α and caspase 3 as well as increased lipid peroxidation and tissue damge in the hippocampus. Furthermore, crocin treatment at a dose of 100 mg/kg attenuated memory impairments, downregulated the mRNA expression of NF-κB, TNF-α and caspase 3 and decreased lipid peroxidation in the hippocampus. Crocin also ameliorated LPS-induced pathological changes and neuronal loss in the hippocampus and cerebral cortex. In conclusion, neuroprotective effects of crocin against LPS-induced histopathological and behavioural changes could be attributed to its anti-apoptotic, anti-inflammatory and radical-scavenging activities in the rat brain.
Weight gain according to Institute of Medicine 2009 in pregnant women with thyroid disorders as per their thyroid status in each trimester
Authors: LIU JIAMING , Xie Xinglei , García-Patterson Apolonia , Asla Queralt , Sardà Helena , Chico Ana , Adelantado Juan M. , Urgell Eulalia , Corcoy Rosa
Published: February 2024

Purpose We aimed to evaluate, in women with thyroid disorders the relationship between maternal thyroid status in each trimester and GWG according to Institute of Medicine (IOM).Methods Retrospective analysis of 782 pregnant women either receiving treatment with levothyroxine or attended because of hyperthyroidism. We used four summary measures of maternal thyroid status as predictors of GWG according to IOM: individual trimesters/at some point during pregnancy, subclinical and overt conditions combined/split.Results In women treated with levothyroxine, associations between maternal thyroid status and GWG were observed in three models. As an example, hyperthyroidism (subclinical/overt combined) in the second trimester, was associated with both insufficient (aOR: 2.96, 95% CI: 1.07–8.22) and excessive GWG (aOR: 3.25, 95% CI: 1.10–9.62). In women followed by hyperthyroidism, associations were observed in the four models. As an example, overt hypothyroidism at some point during pregnancy was associated with both insufficient GWG (aOR: 10.61, 95% CI: 2.23–50.36) and excessive GWG (aOR: 5.36, 95% CI: 1.34–21.51).Conclusions In these cohorts of pregnant women treated with levothyroxine or attended for hyperthyroidism, both maternal hypo and hyperthyroidism status display strong associations with GWG according to IOM both in expected and unexpected directions.
A SOMA-inspired Hybrid Variant of Grasshopper Optimization Algorithm for Global Optimization
Authors: Chand Neha , Singh Dipti
Published: February 2024

The Grasshopper Optimization Algorithm (GOA) is a relatively recent population-based stochastic search algorithm extensively used for solving various nonlinear global optimization problems arising in science and engineering. Like other evolutionary algorithms, this algorithm also has some limitations like poor balance between exploration and exploitation, requires large population size, and premature convergence. To address these limitations and to improve the efficiency of GOA, two hybridized variants of GOA have been proposed in this paper. In these variants, GOA is combined with the feature of another population-based algorithm which is the Self-Organizing Migrating Algorithm (SOMA). First GOA is combined with the exploitation feature of SOMA and a hybrid variant of SOMGOA is proposed. Later to balance exploitation, SOMGOA is merged with tournament selection to maintain the good quality solution of previous and current generations and SOMGOA-t is presented. The effectiveness of both the variants is analysed based on results and comparative analysis is made against the results of GOA and SOMA. A total of twenty-one standard benchmark functions with different intrinsic difficulties and four unconstrained optimization problems (gear train design, frequency modulation sound parameter identification problem, Gas transmission compressor design problem, and Optimal capacity of gas production facility) have been used for testing. The analysis of experimental results involved two statistical tests: the Wilcoxon rank-sum test and the Friedman statistical test. Furthermore, the statistical findings consistently affirm the superiority of the SOMGOA-t when compared to the alternative algorithms (GOA and SOMA). However, the present study is limited to solving unconstrained nonlinear optimization problems.
Comparative assessment of DCGANS and autoencoder-based models for image inpainting
Authors: Mohamed Mahmoud , Alosman Khalid
Published: February 2024

Image inpainting aims to fill missing or corrupted regions in images with semantically coherent content. This paper presents an expanded comparative study evaluating deep generative adversarial networks (GANs) and autoencoder models for image inpainting. We conduct extensive experiments and analysis on Places365 dataset images with missing regions. The literature review is significantly expanded to cover the latest advancements in deep learning based inpainting. Methodology details are enhanced with additional architectural specifications, training procedures, evaluation metrics, and ablation studies. Comprehensive quantitative metrics, qualitative visual comparisons, user studies, and ablation studies provide novel insights into model capabilities and limitations. Results analysis is also broadened to provide more in-depth discussion of performance trade-offs. Our findings reveal complementary strengths of GANs in perceptual quality and autoencoders in reconstruction accuracy. Hybrid approaches can balance these properties for high fidelity inpainting. The expanded study offers rich insights to guide optimal selection and design of deep generative architectures for advancing image inpainting across diverse applications.
Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation
Authors: Pugalenthi Pradeep Varathan , He Bing , Xie Linhui , Nho Kwangsik , Saykin Andrew J , Yan Jingwen
Published: February 2024

Alzheimer’s disease (AD) is a highly heritable brain dementia, along with substantial failure of cognitive function. Large-scale genome-wide association studies (GWASs) have led to a significant set of SNPs associated with AD and related traits. GWAS hits usually emerge as clusters where a lead SNP with the highest significance is surrounded by other less significant neighboring SNPs. Although functionality is not guaranteed even with the strongest associations in GWASs, lead SNPs have historically been the focus of the field, with the remaining associations inferred to be redundant. Recent deep genome annotation tools enable the prediction of function from a segment of a DNA sequence with significantly improved precision, which allows in-silico mutagenesis to interrogate the functional effect of SNP alleles. In this project, we explored the impact of top AD GWAS hits on chromatin functions and whether it will be altered by the genetic context (i.e., alleles of neighboring SNPs). Our results showed that highly correlated SNPs in the same LD block could have distinct impacts on downstream functions. Although some GWAS lead SNPs showed dominant functional effects regardless of the neighborhood SNP alleles, several other SNPs did exhibit enhanced loss or gain of function under certain genetic contexts, suggesting potential additional information hidden in the LD blocks and the need for reanalysis of GWAS findings as clusters.
Analysis of CCND3 mutations in diffuse large B-cell lymphoma
Authors: Hua Wei , Li Yue , Yin Hua , Du Kai-Xin , Zhang Xin-Yu , Wu Jia-Zhu , Liang Jun-Heng , Shen Hao-Rui , Gao Rui , Li Jian-Yong , Wang Li , Liang Jin-Hua , Xu Wei
Published: February 2024

Diffuse large B-cell lymphoma (DLBCL), accounts for 30–40% of newly diagnosed lymphomas, has an overall cure rate of approximately 60%. Despite previous reports suggesting a negative prognostic association between CCND3 mutations and Burkitt lymphoma, their prognostic implications in DLBCL remain controversial. To investigate this, we evaluated CCND3 mutation status in 2059 DLBCL patient samples from four database (integrated cohort) and additional 167 DLBCL patient samples in our center (JSPH cohort). The mutation was identified in 5.9% (132/2226) of the cases in the integrated cohort, with 86% (97/113) found in exon 5. Furthermore, P284, R271, I290 and Q276 are described as CCND3 mutation hotspots. CCND3 mutation was associated with decreased overall survival (OS) in the integrated cohort (P = 0.0407). Further subgroup analysis revealed that patients diagnosed as EZB subtype DLBCL by LymphGen algorithm with CCND3 mutations had poorer OS than patients diagnosed as EZB subtype without CCND3 mutations (P = 0.0140). Using the next-generation sequencing (NGS) in the JSPH cohort, it was found that both cell cycle and DNA replication pathways were highly upregulated in patients with CCND3 mutations. Our results suggest that CCND3 mutations can serve as a novel prognostic factor in DLBCL pathogenesis. Consequently, the development of personalized therapeutic strategies for DLBCL patients with CCND3 mutations might enhance their prognosis.
Targeting excessive skin cholesterol deposition driven by lymphatic insufficiency alleviates secondary lymphedema
Authors: Angeli Veronique , Lim Hwee Ying , Azhar Syaza Hazwany Mohammad , Yunos Mohamed Ameen Shah Bin Mohamed , Zhang Yuning , Thiam Chung Hwee , Tan Shu Wen , Lim Sheau Yng , Goh Jasmine , Ng Si Hui , Cochran Blake , Tham Wai Kin , Ang Owen , Mause Sebastian , Torta Federico , WENK MARKUS , Rye Kerry-Anne , Tan Bien Keem
Published: February 2024

Lymphedema is a chronic debilitating disease caused by impaired lymphatic drainage and is characterized by tissue swelling, fat expansion, inflammation, and fibrosis1,2. However, the exact mechanisms driving lymphedema are poorly understood. Lymphatic vessels are known to transport lipids including cholesterol from peripheral tissues back to the blood circulation3 but the impact of impaired lymphatic drainage on cholesterol clearance in humans and its potential effects on tissue homeostasis are still unknown. Here, we show that lymphatic drainage insufficiency in human lymphedema leads to excessive cholesterol accumulation in subcutaneous tissue. Cholesterol deposition resulted in adipose tissue remodeling, progressing from adipocyte hypertrophy and dysfunction to death and tissue fibrosis. Surgical therapy, on the other hand reversed the process through improved lymphatic drainage, ultimately resulting in reduced cholesterol deposition. We established a mouse model that better reproduces the features of human lymphedema and demonstrated that tissue swelling, adipocyte hypertrophy and fibrosis were reversed by cholesterol depleting agents including high-density lipoprotein and cyclodextrin (CD) that improved lymphatic drainage upon increasing cholesterol clearance and/or solubility. Ex vivo, CD also efficiently removed cholesterol from human lymphedematous skin biopsy samples. Our study unravels the central role of impaired cholesterol clearance in driving lymphedema progression by promoting adipose tissue remodeling and identifies tissue cholesterol as a promising therapeutic target for this disease which is incurable. Our work highlights the importance of optimal lymphatic drainage to protect against excess cholesterol and its harmful effects. This concept is known in atherosclerosis and may apply to other human diseases including neurological disorders, liver, and metabolic diseases.
Brillouin Expanded Time-Domain Analysis based on Dual Optical Frequency Combs
Authors: Song Kwang-Yong , Yoon Jae Hyeong , Martin-Lopez Sonia , Gonzalez-Herraez Miguel , Fernández-Ruiz María
Published: February 2024

Brillouin Optical Time-Domain Analysis (BOTDA) is a widely-used distributed optical fiber sensing technology employing pulse-modulated pump waves for local information retrieval of the Brillouin gain or loss spectra. The spatial resolution of BOTDA systems is intrinsically linked to pulse duration, so high-resolution measurements demand high electronic bandwidths inversely proportional to the resolution. This paper introduces Brillouin Expanded Time-Domain Analysis (BETDA) as a modified BOTDA system, simultaneously achieving high spatial resolution and low detection bandwidth. Utilizing two optical frequency combs (OFCs) with different frequency intervals as pump and probe, local Brillouin gain spectra are recorded by their spectral beating traces in an expanded time domain. A 2-cm-long hotspot located at 230 m single-mode fiber is successfully measured in the time domain with a detection bandwidth of less than 100 kHz using dual OFCs with tailored spectral phase, line spacing, and bandwidth.
Disturbance Observer - Based Finite-Time Fault Tolerant Control of Quadrotor Unmanned Aerial Vehicles with Command Filtered and Event-Triggered Techniques
Authors: Sun Yun , Gai Yulin , Chen Ming , Wang Hangqing , Peng Kaixiang , Wu Libing
Published: February 2024

This article primarily focuses on the finite-time
fault-tolerant tracking control problem of quadrotor unmanned
aerial vehicle (UAV) systems. A simple cubic form of the
Lyapunov function is employed, which avoids the limitations
imposed by the previous absolute value form. Additionally,
the command filter technology and a disturbance observer are
introduced. The former effectively addresses the challenges of
complex coupling matrix differentiation during controller design,
while the latter approximates unknown disturbance terms in the
model. Moreover, the application of an event-triggered strategy
enhances the utilization of communication resources. The overall
approach combines the backstepping method and finite-time
Lyapunov stability to prove the finite-time stability of all the
signals in the system. Finally, the effectiveness and rationality of
the algorithm are verified through simulation experiments and
its application on an actual simulation platform
Genomic and transcriptome analyses reveal the molecular basis for erucic acid biosynthesis in seeds of rapeseed (Brassica napus)
Authors: Xu Shiqi , Chen Shan , Cai Jialing , Yan Tao , Tu Mengxin , Wang Ruisen , Hua Shuijin , Jiang Lixi
Published: February 2024

Erucic acid (EA) is an important quality trait in rapeseed with low EA content (LEAC) oil being recognized as a healthy edible oil and high EA oil holding industrial value. Despite its importance, the consequences of intensive selection for LEAC genotype and the genes associated with EA regulation remain largely unknown. Here, we employed selective signal analyses (SSA), genome-wide association study (GWAS), and transcriptome analyses to enhance our understanding on the molecular base of EA regulation. Our investigation revealed the genetic footprints resulting from LEAC selection in germplasm populations, highlighting genetic regions for enriching diversity. Through GWAS, we identified 654 genes, including enzymes involved in the fatty acid biosynthesis and various transcription factors, that significantly associated with EAC variation. By combining SSA, GWAS, and transcriptome analyses, a subset of 23 genes that have a significant impact on EAC in seeds is recommended. Example genes such as Fatty Acid Elongation 1 and Methylcrotonoyl-CoA Carboxylase Beta Chain were selected to illustrate the SNP distributions, haplotypes for EAC phenotypes and the development of molecular marker to distinguish LEAC and HEAC genotypes. These findings provide insights into the mechanism of EA regulation and shed light on the manipulation of the genes regulating EA biosynthesis.
Microscale analysis of the fish Knightia eocaena taphonomy: implications for preservation by bacterial mats
Authors: Rogers Garrett A , Pittinger Dakota , Simpson Edward L , Friehauf Kurt
Published: February 2024

Field Emission Scanning Electron Microscope (FESEM) and Energy Dispersive Spectroscopy System (EDS) examination of well-preserved Knightia eocaena from the Eocene Green River documents the presence of bacteriomorphs. Bacteriomorphs in samples from the_ Fossil Butte Member consists of fibers with two types and spherical structures, all with associated framboidal Fe-oxides. Fibers and spheres consist of external molds composed of nano-scale calcium carbonate spheres. Fish bone surfaces are corroded by framboids and euhedral rhombohedral molds. Fe-oxide framboids have an amorphous exterior and a sieve-like internal structure. The sieve-like structure consists of nannometer-scale pores with wall composed of 100 nm scale spheres. Fe-oxides are consistent with bacterial-mediated precipitation of pyrite followed by an oxidation event. The presence of the preserved bacteriomorphs is consistent with degradation of soft tissue degradation into adipocere limiting the preservation of soft tissue and leaving refracted bone.
A portable affective computing system for identifying mate preference
Authors: Yuan Guangjie , Wang Tao , Ju Wei , Fu Sai
Published: February 2024

Recognizing individuals' preference states for potential romantic partners based on electroencephalography (EEG) signals holds significant application value in enhancing matchmaking success rates and preventing romantic fraud. Despite some progress has been made in this field, challenges such as high-dimensional feature space and channel redundancy have hindered the translation of this technology. This paper explores how to find out the most discriminative EEG features and channels to reduce data collection, thereby enhancing the convenience and translational potential of EEG-based romantic attraction recognition systems. For this purpose, the present study initially devised an interesting simulated mate selection experiment to gather the required data. Subsequently, EEG features were extracted from different dimensions, encompassing frequency band power and asymmetry index features. Additionally, recursive feature elimination (RFE) algorithm and frequency-based feature subset integration algorithm (FFSI) were integrated as a novel approach for EEG feature and channel selection. Lastly, random forest classifier (RFC) was employed to identify individuals' preference states for potential romantic partners to validate the performance of RFE-FFSI. Experimental results demonstrate that the features in the optimal feature subset primarily come from electrodes located on the frontal lobe, and an average classification accuracy of 88.09% can be achieved based on this optimal feature subset.
Analysis on the Law of Mine Pressure and the Adaptability of Supports in Filling Coal Mining under the Condition of Repeated Mining
Authors: Huang Rongbin , Dong Mingming
Published: February 2024

Based on the 31205 filling face in Northern Shaanxi, China, this paper uses the combination of numerical simulation, field measurement and data analysis to analyze the law of overburden stress distribution, the behavior law of periodic pressure and the stress characteristics of support in the process of filling coal mining under repeated mining conditions. Affected by the arch forming effect of the upper working face, the stress of the surrounding rock under the upper coal pillar is obviously concentrated.The roof of the lower coal seam presents the stress characteristics of plate structure, which leads to the obvious increase of the vertical stress of the surrounding rock at the boundary of the lower goaf. However, affected by the upper goaf, the roof support point moves below the upper coal pillar. Under the load transfer action of the upper coal pillar, the lower surrounding rock is prone to plastic failure, resulting in violent movement of the surrounding rock. Compared with the surrounding rock under the goaf, the movement of overburden under the coal pillar is more intense. The periodic pressure law of the working face below the upper coal pillar is different from that of the working face below the upper goaf. Affected by the upper coal seam, the support resistance is asymmetrically distributed, and its maximum support resistance is located below the upper coal pillar.
Impact of beef cattle on eucalyptus trees in a silvopastoral system
Authors: Carneiro L. Souza , Pontes L. Silveira , Rodrigues D. , Mendes L. Chiezi , Porfírio-da-Silva V.
Published: February 2024

Eucalyptus species are widely adopted in silvopastoral systems in Brazil due to their adaptive potential to different climates and soils. However, damages caused by cattle to trees may compromise the system’s success. The aim of this study was to determine the impact of beef cattle on Eucalyptus grandis clone GPC 23 trees during the grazing period in an integrated crop-livestock with trees (CLT) system of Avena strigosa + Lolium multiflorum. The effect of two N levels (50 x 150 kg/ha) on animal and forage production were also evaluated, with the integrated crop-livestock system (CL) serving as control. The experimental design was randomized blocks of treatments arranged in a 2×2 factorial scheme (2 systems x 2 N levels), with three replicates. In winter 2022, forage production and animal performance, assessed as average daily gain (ADG) and live weight gain (LW) per area per day (Gha/day), were evaluated during 139 days of grazing. Total forage production, ADG, and Gha/day were higher in CL (7972 ± 775.7 kg DM/ha, 0.799 ± 0.0392 kg/animal/day and 4.27 ± 0.259 kg LW/ha/day, respectively) than in (6478 ± 350.9 kg DM/ha, 0.638 ± 0.0546 kg/animal/day and 2.91 ± 0.259 kg LW/ha/day), even at similar sward heights (between 22 and 24 cm). The animals damaged the bark of the trees, even after the trees had reached a diameter at breast height of 9.9 cm. The damage was classified as high intensity in 91.1% of the trees, affecting their quality as sawn wood. Preventive measures must be adopted regarding the use of E. grandis in a silvopastoral system with cool-season grasses.
Electrical De-poling and Re-poling of Relaxor-PbTiO3 Piezoelectric Single Crystals without Heat Treatment
Authors: Jiang Xiaoning , Kim Hwang-Pill , Zhang Mao-Hua , Wang Bo , Wu Huaiyu , Moon Sunho , Xu Zhengze , Yamashita Yohachi , Ryu Jong , Liu Jun , Zhang Shujun , Chen Long-Qing
Published: February 2024

Re-poling of unexpected partially depoled piezoelectric materials conventionally need to be first fully depoled through annealing above their Curie temperature (Tc) to revive piezoelectric performances. Here, we investigated de-poling and re-poling of Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 (PIN-PMN-PT) single crystals under electric fields at room temperature. We found that alternating current (AC) electric fields with amplitudes near the coercive field (Ec) at low frequencies (< 10 Hz) can be employed to successfully depolarize poled crystals at room temperature. We also demonstrated a reversible polarization switching process with a relaxor-PT single crystal ultrasound transducer without device performance degradation. This experimental observation is supported by phase-field simulation, showing that AC electric fields can readily induce de-poling at room temperature, while DC electric fields induce a transient depoled state only within an uncontrollable short period of time. The findings suggested new strategies for unprecedented in-device tailoring of the polarization states of ferroelectric materials.
Risk-Aware Framework Development for Disruption Prediction:Alcator C-Mod and DIII-D Survival Analysis
Authors: Keith Zander , Nagpal Chirag , Rea Cristina , Tinguely R. Alex
Published: February 2024

Survival regression models can achieve longer warning times at similar receiver operating characteristic performance than previously investigated models. Survival regression models are also shown to predict the time until a disruption will occur with lower error than other predictors. Time-to-event predictions from time-series data can be obtained with a survival analysis statistical framework, and there have been many tools developed for this task which we aim to apply to disruption prediction. Using the open-source Auton-Survival package we have implemented disruption predictors with the survival regression models Cox Proportional Hazards, Deep Cox Proportional Hazards, and Deep Survival Machines. To compare with previous work, we also include predictors using a Random Forest binary classifier, and a conditional Kaplan-Meier formalism. We benchmarked the performance of these five predictors using experimental data from Alcator C-Mod and DIII-D by simulating alarms on each individual shot. We find that developing machine-relevant metrics to evaluate models is an important area for future work. While this study finds cases where disruptive conditions are not predicted, there are instances where the desired outcome is produced. Giving the plasma control system the expected time-to-disruption will allow it to determine the optimal actuator response in real-time to minimize risk of damage to the device.
Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery
Authors: SUPRIYA ODDAPELLI SAI , KAMERE KISHORE , VIJAYKUMAR GAMPA
Published: February 2024

Micro needle patches are the novel dosage form in transdermal drug delivery systems with improved penetration to skin. In this study we fabricated micro needle patches containing Raloxifene an immunosuppressant drug by using polymer thiolated chitosan that in turn was developed by adding thiol group to chitosan. These micro needle patches were further evaluated for their mechanical, physical and chemical parameters. The optimized micro needle patch having 225 needles with 665 µm length, 90 µm width showed good penetration i.e 84% and better percent elongation. In-vitro and ex-vivo penetration studies on rat skin using Franz diffusion cell showed sustained release of (85%) Raloxifene in its comparative study with Raloxifene ointment. HPLC analysis also showed 91.7% release of drug from optimized formulation of micro needle patch. Finally the recent progress proved that micro needle patches of thiolated chitosan loaded with Raloxifene for transdermal drug delivery have the potential to show therapeutic outcomes with improved bioavailability and sustained release of drug over a longer period.
A sexually transmitted sugar orchestrates reproductive responses to nutritional stress
Authors: Kim Young Joon , Kim Seong-Jin , Lee Kang-min , Park Si Hyung , Yang Taekyun , Song Ingyu , Rai Fumika , Yun Minsik , Zhang Chen , Dus Monica , Kim Jae-Il , Lee Sunjae , Suh Greg S. B. , Niwa Ryusuke , Park Zee Yong
Published: February 2024

Seminal fluid is rich in sugars, but their role beyond supporting sperm motility is unknown. In this study, we found Drosophila melanogaster males transfer a substantial amount of a phospho-galactoside to females during mating, but only half as much when undernourished. This seminal substance, which we named venerose, induces an increase in germline stem cells (GSCs) and promotes sperm storage in females, especially undernourished ones. Venerose enters the hemolymph and directly activates nutrient-sensing Dh44+ neurons in the brain. Food deprivation directs the nutrient-sensing neurons to secrete more of the neuropeptide Dh44 in response to infused venerose. The secreted Dh44 then enhances the local niche signal, stimulating GSC proliferation. It also extends the retention of ejaculate by females, resulting in greater venerose absorption and increased sperm storage. In this study, we uncovered the role of a sugar-like seminal substance produced by males that coordinates reproductive responses to nutritional challenges in females.
The Impacts of Surface Roughness on Cyclic Shearing Behavior of Interface between Crushed Mudstone and Steel cased Rock-Socketed Pile
Authors: Liang Yue , Zhang Jianlu , Xu Bin , Liu Zeyu , Dai Lei , Wang Kui
Published: February 2024

In the waterway construction projects of the upper streams of the Yangtze River, crushed mudstone particles are widely used to backfill the foundation of rock-socketed concrete-filled steel tube (RSCFST) pile—a structure widely adopted in port constructions. In practice, steel-mudstone interfaces are subjected to complex loading conditions and the surface profile varies in a certain range during construction and operation. The changes in boundary condition and material profile significantly impact the behavior of interface when subjected to cyclic loads, such as ship impacts, water level fluctuations, and wave-induced loads. In this study, a series of cyclic direct shear tests were carried out to investigate the impacts of surface roughness on interface cyclic behavior of RSCFST pile-soil. The relationship between roughness and shear stress, shear stiffness, damping ratio, normal stress, and particle breakage ratio are discussed, respectively. The mechanical behaviors observed at the steel-mudstone interface are as follows: (1) Surface roughness amplifies the initial shear stress, stiffness, and anisotropy at the steel-mudstone interface. However, it results in a reduction of these parameters in their final stages. (2) The damping ratio of the rough interface exhibits an initial increase followed by a decrease, while the smooth interface demonstrates the exact opposite trend. (3) Volumetric strain demonstrates shear contraction and shear dilatancy, both of which become increasingly evident with enhanced roughness. (4) A significant increase in the particle breakage ratio is observed with increased roughness, with the majority of fragmented particles falling within the 0.075–0.25 mm size range.
Formulation and Evaluation of Luliconazole Emulgel
Authors: SHEKAR BODDU , K.RAMESH  , G.VIJAYKUMAR
Published: February 2024

Introduction: In the past few decades, there has been an exponential growth in the field of herbal medicine and excipients. The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Luliconazole using natural gelling agents.
Materials and Methods: Emulgel formulations of Luliconazole were formulated using two types of gelling agents, namely xanthan gum and guar gum. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the formulated emulgel was studied by preparing various batches. The prepared formulations were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, and stability. Luliconazole cream available in market was used for comparison with prepared formulations.
Results and Discussion: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The result of studied revealed that the optimized batch shows 96.04% release in 5 h.
The attenuating effect of the aqueous extract of the Flower of Opuntia ficus indica against lead-induced reprotoxicitè in the wistar rat
Authors: Boudjema Naouel , Ladouali Zyneb
Published: February 2024

The objective of this study is to investigate the beneficial effect of Opuntia ficus indica flower aqueous extract against lead (Pb)-induced reprotoxicité in male Wistar rats administered orally for 4 weeks. These are divided into 6 groups: the control group (C), 2 positive controls treated with the aqueous extract of the flower of Opuntia ficus indica F1 and F2 respectively (250 mg/kg, 500 mg/kg of body weight/day) ;1 group treated with lead (50 mg/kg bodyweight/day) and 2 groups of combined treatment treated with lead and aqueous extract ofopuntia ficus indica flowers (F1 + Pb), (F2 + Pb). Extracts of Opuntia ficus indica flowers are the subject of a phytochemical study. After 30 days of oral administration, the absolute weight of the testicles and of the epididymis, the plasma levels of testosterone are evaluated; in addition to sperm biology parameters (concentration, motility, vitality, velocity (VCL, VSL and VAP), cross-level (BCF) and DNA fragmentation test are evaluated by the CASA system. Testicular glutathione andepididymal (GSH), Malondialdehyde (MDA) and glutathione peroxidase (GPX) are also evaluated. The results obtained show a significant reduction in testosterone levels, absolute testicular and epididymal weights, live sperm, VCL, VSL, VAP, BCF, GSH and GPX as well as an increase in dead spermatozoa and MDA in the group treated with lead (Pb) compared to the control group (C) and the positive controls, the administration of the aqueous extract of the flowers ofopuntia ficus indica in the combination groups (F1 + Pb and F2 + Pb) caused an attenuating effect against lead-induced toxicity. Even the phytochemical study confirms that the methanolic extract of Opuntia ficus indica extract isrich in tannins and flavonoids.
Crystallization behaviors of chain extended poly (lactic acid) modified with ST-NAB3 and its improved mechanical and thermal properties
Authors: Dun Dongxing , Zhu Min , Zhou Hongfu , Li Jian , Hu Jing
Published: February 2024

The widespread use of traditional petroleum-based plastics is causing significant environmental pollution for example microplastics issues, due to its non-biodegradability. Poly (lactic acid) (PLA) as a representative biodegradable polymer is a promising candidate to replace petroleum-based plastics in some fields of disposable packaging materials and tableware. In this work, in order to improve the poor crystallization, mechanical and heat resistance performances of PLA, styrene-acrylonitrile-glycidyl methacrylate (SAG) as a chain extender and octamethylenedicarboxylic dibenzoylhydrazide (ST-NAB3) as a heterogeneous nucleating agent (HNA) were added simultaneously into PLA matrix. The chain-extended PLA (CPLA) with branch structures had smaller crystal sizes and higher crystal density, compared with those of pure PLA. In addition, thanks to the nucleation effect of ST-NAB3 and the development of “shish-kebab”, this tendency became more pronounced in CPLA/HNA systems. It was worth mentioning that, CPLA with the ST-NAB3 content of 1 wt.% (CPLA-1) possessed the highest crystallinity of 43.6%. Meanwhile, CPLA-1 had the best impact strength and heat deformation temperature of 38.9 kJ/m2 and 91.3°C respectively, which had increased by 11.3 kJ/m2 and 32.4°C contrast to pure PLA. On the whole, this study proposed a simple and effective method, which provided a new possibility for PLA modification research.
Learning Professional Terminology With AI-Based Tutors in Technical University
Authors: Zhubanova Sholpan , Beissenov Renat , Goktas Yuksel
Published: February 2024

This paper analyses the incorporation of artificial intelligence (AI) into Kazakhstani technical universities to improve the acquisition of professional English terminology. The literature review investigates the role of artificial intelligence (AI) in foreign language instruction, providing a detailed overview of prospects and limitations. This study presents a framework for introducing AI-based instructors into technical foreign language teaching. The research approach included 30 students from various academic backgrounds in the experimental group and 33 students from the control group. The effectiveness of AI-based tutors is evaluated through surveys and interviews with students and teachers. This study provides a thorough examination of AI tutor creation, classroom use, and evaluation criteria. Interviews with technical university lecturers yielded insights into both potential and obstacles. The results of a survey show that students have differing opinions about the efficiency of AI tutors. The discussion contextualizes the findings in light of past research, emphasizing the multidimensional impact of AI on education. It argues for a balanced approach, viewing AI as a supplement rather than a replacement for critical thinking. There is practical advice for educators and legislators. The essay provides opportunities for future research while acknowledging constraints such as technical challenges and changing student interest.