bluuebunny/crossref_metadata_2025 huggingface dataset:
Regorafenib Plus Nivolumab in Patients With Advanced Gastric or Colorectal Cancer: An Open-Label, Dose-Escalation, and Dose-Expansion Phase Ib Trial (REGONIVO, EPOC1603)
Authors: Fukuoka Shota , Hara Hiroki , Takahashi Naoki , Kojima Takashi , Kawazoe Akihito , Asayama Masako , Yoshii Takako , Kotani Daisuke , Tamura Hitomi , Mikamoto Yuichi , Hirano Nami , Wakabayashi Masashi , Nomura Shogo , Sato Akihiro , Kuwata Takeshi , Togashi Yosuke , Nishikawa Hiroyoshi , Shitara Kohei
Published: April 2020

PURPOSE

This is a phase Ib trial of regorafenib plus nivolumab for gastric and colorectal cancer.

PATIENTS AND METHODS

Enrolled patients received regorafenib plus nivolumab in a dose-finding part to estimate the maximum tolerated dose. Additional patients were enrolled in a dose-expansion part. Regorafenib of 80-160 mg was administered once daily for 21 days on/7 days off with nivolumab 3 mg/kg every 2 weeks. The primary end point was dose-limiting toxicity (DLT) during the first 4 weeks to estimate the recommended dose.

RESULTS

Fifty patients (25 each with gastric and colorectal cancer) were enrolled. All patients had received ≥ 2 previous lines of chemotherapy, including anti-angiogenetic inhibitors in 96% of patients. Seven patients with gastric cancer had previously been treated with immune checkpoint inhibitors. One patient had microsatellite instability–high colorectal cancer, whereas the remaining patients had microsatellite stable or mismatch repair–proficient tumors. Three DLTs (grade 3 colonic perforation, maculopapular rash, and proteinuria) were observed with regorafenib 160 mg; none were observed with 80 or 120 mg. During the dose-expansion part, regorafenib dose was reduced from 120 to 80 mg because of frequent maculopapular rash. The common grade ≥ 3 treatment-related adverse events were rash (12%), proteinuria (12%), and palmar-plantar erythrodysesthesia (10%). Objective tumor response was observed in 20 patients (40%), including 11 with gastric cancer (44%) and 9 with colorectal cancer (36%). Median progression-free survival was 5.6 and 7.9 months in patients with gastric and colorectal cancer, respectively.

CONCLUSION

The combination of regorafenib 80 mg plus nivolumab had a manageable safety profile and encouraging antitumor activity in patients with gastric and colorectal cancer, which warrants additional investigations in larger cohorts.
Multi-level analysis of the interactions between REVOLUTA and MORE AXILLARY BRANCHES 2 in controlling plant development reveals parallel, independent and antagonistic functions
Authors: Hong Shin-Young , Botterweg-Paredes Esther , Doll Jasmin , Eguen Tenai , Blaakmeer Anko , Matton Sanne , Xie Yakun , Lunding Bjørg Skjøth , Zentgraf Ulrike , Guan Chunmei , Jiao Yuling , Wenkel Stephan
Published: April 2020

Class III homeodomain leucine zipper (HD-ZIPIII) transcription factors play fundamental roles in controlling plant development. The known HD-ZIPIII target genes encode proteins involved in the production and dissipation of the auxin signal, HD-ZIPII transcription factors and components that feedback-regulate HD-ZIPIII expression or protein activity. Here we investigated the regulatory hierarchies of the control of MORE AXILLARY BRANCHES2 (MAX2) by the HD-ZIPIII protein REVOLUTA (REV). We found that REV can interact with the promoter of MAX2. In agreement had rev10D, gain-of-function mutants increased levels of MAX2 expression while rev loss-of-function mutants showed lower levels of MAX2 in some tissues. Like REV, plays MAX2 known roles in the control of plant architecture, photobiology and senescence which prompted us to initiate a multi-level analysis of growth phenotypes of hd-zipIII, max2 and respective higher order mutants thereof. Our data suggest a complex relationship of synergistic and antagonistic activities between REV and MAX2 and these interactions appear to depend on the developmental context and not all involve the direct regulation of MAX2 by REV.
Photoelectrochemical Properties of Particulate CuGaSe2 and CuIn0.7Ga0.3Se2 Photocathodes in Nonaqueous Electrolyte
Authors: Kageshima Yosuke , Shiga Sota , Kumagai Hiromu , Teshima Katsuya , Domen Kazunari , Nishikiori Hiromasa
Published: April 2020

The photoelectrochemical (PEC) properties of particulate CuGaSe2 (CGSe) and CuIn0.7Ga0.3Se2 (CIGS) photocathodes were evaluated in an acetonitrile electrolyte containing iron(III) acetylacetonate (Fe(acac)3) under simulated sunlight illumination, and compared to that in a typical aqueous electrolyte. The particulate CGSe and CIGS photocathodes can generate higher photovoltages, which is a more positive onset potential than the hydrogen evolution in an aqueous electrolyte possibly due to the facile one-electron reduction of Fe(acac)3, while the cathodic photocurrent decreased due to light shielding by the colored nonaqueous electrolyte. Indeed, the incident-photon-to-current conversion efficiencies (IPCEs) of the photocathode evidently decreased in the wavelength region of 400–600 nm, where the Fe(acac)3 acetonitrile electrolyte shows an intense light absorption. The CIGS photocathode generates a higher cathodic photocurrent than the CGSe during hydrogen evolution from the aqueous electrolyte, while the CGSe exhibits superior PEC performances to CIGS in the nonaqueous electrolyte, which can be explained by the energy level of the conduction band minimum (CBM) of CGSe and CIGS compared to the reduction potential for Fe(acac)3. Finally, the two-electrode PEC-voltaic (PECV) cell consisting of the CGSe photocathode and Pt anode demonstrated a stable generated photovoltage by a one-step photoexcitation process.
Is There a Link between Stress and Cognition, and Capacity to Execute Motor Skill?
Authors: SERPELL BENJAMIN G. , WADDINGTON GORDON , MCGRATH BRADEN , COOK CHRISTIAN J.
Published: April 2020

Purpose

This study aimed to examine the link between stress (measured via salivary cortisol and testosterone), cognition (measured via pupillometry, with greater pupil constriction and reduced pupil constriction latency associated with increased attention and improved information processing), and motor skill capacity (measured via somatosensory processing).

Methods

Twenty-five professional rugby players participated in this study. Saliva samples were collected upon waking, before pupillometry and somatosensory processing testing, and after testing. Testing times varied for participants; however, it was always in the morning, and the order of testing was randomized.

Results

Very small differences in hormone concentrations were seen across the morning (effect size = 0.01). Moderate to large differences in left eye pupil constriction for direct (left eye) versus consensual (right eye) stimulus were also seen (P < 0.01; effect size = 0.51 to 1.04). No differences for pupil constriction latency were seen for direct versus consensual stimulus. Some positive weak to moderate relationships were seen for testosterone and pupil constriction latency (r = 0.37 to 0.39, P < 0.05). Moderate to strong inverse relationships were seen for hormones with left eye pupil constriction difference between direct and consensual stimulus, and for pre- to posttest testosterone-to-cortisol ratio decline with left eye pupil constriction for direct and consensual stimulus (r = 0.41 to 0.52, P < 0.05). Weak to moderate inverse relationships for testosterone-to-cortisol ratio decline and somatosensory processing were seen (r = 0.36 to 0.47, P < 0.05).

Conclusion

Stress may affect ability to receive information and ability to execute motor tasks. Thus, stress may compromise ability to make appropriate objective decisions and consequently execute skill/task behavior. Strategies to help mitigate negative stress responses are noted.
Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model
Authors: Akdogan-Ozdilek Bagdeser , Duval Katherine L , Goll Mary G
Published: April 2020

Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes in chromatin structure and in the DNA and histone modifications that help shape this structure. Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transition, when the zygotic genome is first transcribed and maternally loaded transcripts are degraded. The accessibility of the early zebrafish embryo facilitates the interrogation of chromatin during this critical window of development, making it an important model for early chromatin regulation. Here, we review our current understanding of chromatin dynamics during early zebrafish development, highlighting new advances as well as similarities and differences between early chromatin regulation in zebrafish and other species.
Recent advances in influenza vaccines
Authors: Pawelec Graham , McElhaney Janet
Published: April 2020

Seasonal influenza remains a major public health problem, responsible for hundreds of thousands of deaths every year, mostly of elderly people. Despite the wide availability of vaccines, there are multiple problems decreasing the effectiveness of vaccination programs. These include viral variability and hence the requirement to match strains by estimating which will become prevalent each season, problems associated with vaccine and adjuvant production, and the route of administration as well as the perceived lower vaccine efficiency in older adults. Clinical protection is still suboptimal for all of these reasons, and vaccine uptake remains too low in most countries. Efforts to improve the effectiveness of influenza vaccines include developing universal vaccines independent of the circulating strains in any particular season and stimulating cellular as well as humoral responses, especially in the elderly. This commentary assesses progress over the last 3 years towards achieving these aims. Since the beginning of 2020, an unprecedented international academic and industrial effort to develop effective vaccines against the new coronavirus SARS-CoV-2 has diverted attention away from influenza, but many of the lessons learned for the one will synergize with the other to mutual advantage. And, unlike the SARS-1 epidemic and, we hope, the SARS-CoV-2 pandemic, influenza will not be eliminated and thus efforts to improve influenza vaccines will remain of crucial importance.
Gilles de la Tourette Syndrome: advice in the times of COVID-19
Authors: Robertson Mary M. , Eapen Valsamma , Rizzo Renata , Stern Jeremy S. , Hartmann Andreas
Published: April 2020

The novel coronavirus disease (COVID-19) was identified as the cause of an outbreak of respiratory disease in China at the end of 2019. It then spread with enormous rapidity and by mid-March 2020 was declared a world pandemic. Gilles de la Tourette Syndrome (GTS) is a childhood-onset neurodevelopmental disorder with a worldwide prevalence of about 1% of the population. The clinical symptoms include multiple motor and one or more phonic (vocal) tics. Germane to this communication is that 85% of patients with GTS have associated psychiatric co-morbidities, many of which are being exacerbated in the current global health crisis. In addition, several symptoms of GTS may mimic COVID-19, such as a dry cough and sniffing (phonic tics), while other symptoms such as spitting, inappropriate touching of others and “non-obscene socially inappropriate symptoms” can potentially get patients with GTS into trouble with the law. We suggest that a clear explanation of the COVID-19 illness and GTS is important to enable colleagues of various specialities who tend to patients with GTS. It is important to acknowledge at the outset that the information available on the COVID-19 pandemic changes daily, including cases infected, deaths reported, and how various national health systems are planning and or coping or not. It is fair to say that having read the current medical and lay press we conclude that it is not easy to reassure our patients with absolute certainty. However, notwithstanding that, we hope our documentation is of some assistance.
A non-fluorescent HaloTag blocker for improved measurement and visualization of protein synthesis in living cells
Authors: Cohen Laurie D. , Boulos Ayub , Ziv Noam E.
Published: April 2020

Background: HaloTag is a modified bacterial enzyme that binds rapidly and irreversibly to an array of synthetic ligands, including chemical dyes. When expressed in live cells in conjunction with a protein of interest, HaloTag can be used to study protein trafficking, synthesis, and degradation. For instance, sequential HaloTag labeling with spectrally separable dyes can be used to separate preexisting protein pools from proteins newly synthesized following experimental manipulations or the passage of time. Unfortunately, incomplete labeling by the first dye, or labeling by residual, trapped dye pools can confound interpretation.

Methods: Labeling specificity of newly synthesized proteins could be improved by blocking residual binding sites. To that end, we synthesized a non-fluorescent, cell permeable blocker (1-chloro-6-(2-propoxyethoxy)hexane; CPXH), essentially the HaloTag ligand backbone without the reactive amine used to attach fluorescent groups.

Results: High-content imaging was used to quantify the ability of CPXH to block HaloTag ligand binding in live HEK cells expressing a fusion protein of mTurquoise2 and HaloTag. Full saturation was observed at CPXH concentrations of 5-10 µM at 30 min. No overt effects on cell viability were observed at any concentration or treatment duration. The ability of CPXH to improve the reliability of newly synthesized protein detection was then demonstrated in live cortical neurons expressing the mTurquoise2-HaloTag fusion protein, in both single and dual labeling time lapse experiments. Practically no labeling was observed after blocking HaloTag binding sites with CPXH when protein synthesis was suppressed with cycloheximide, confirming the identification of newly synthesized protein copies as such, while providing estimates of protein synthesis suppression in these experiments.

Conclusions: CPXH is a reliable (and inexpensive) non-fluorescent ligand for improving assessment of protein-of-interest metabolism in live cells using HaloTag technology.
Next Lives Here: Forging Academia–Industry Partnerships in Analytics at the University of Cincinnati
Authors: Fry Michael J. , Camm Jeffrey D. , Wegryn Glenn
Published: April 2020

In 2018, the Department of Operations, Business Analytics, and Information Systems (OBAIS) in the Carl H. Lindner College of Business at the University of Cincinnati (UC) celebrated its 50th anniversary, and in 2019 the OBAIS department won the INFORMS UPS George D. Smith Prize. The OBAIS department has a long history of excellence in fostering academia-industry collaboration in the area of analytics as well as a track record of continued innovation. In this article, we summarize some of the history of the OBAIS department and describe many of the department’s innovations that enabled the department to win the 2019 Smith Prize. We provide an overview of the department’s curriculum of analytics-focused degree programs, and we explain how the UC Center for Business Analytics serves as the culmination of the department’s efforts to provide a supportive ecosystem in analytics for students, faculty, business leaders, and practitioners. We conclude with some lessons learned along our journey.
Assortative Matching and Reputation in the Market for First Issues
Authors: Akkus Oktay , Cookson J. Anthony , Hortaçsu Ali
Published: April 2020

Using a tractable structural model of the matching equilibrium between underwriters and equity-issuing firms, we study the determinants of value in underwriter–firm relationships. Our estimates imply that high underwriter prestige is associated with 5.3%–14.1% greater equilibrium surplus. According to the structural model, high prestige exhibits a significant certification effect throughout the sample (1985–2010), but there is also a countervailing effect of underwriter prestige that reflects subscriber preferences for more underpricing. Consistent with trading off profits from issuers and subscribers, high-prestige underwriters underprice more in hot markets when rents to catering to subscribers are greatest.

This paper was accepted by Gustavo Manso, finance.
A qualitative study of the physical consequences experienced by women with cervical cancer in Accra, Ghana
Authors: Hobenu Kafui A , Naab Florence
Published: April 2020

Background/aims

Cervical cancer is a highly prevalent type of cancer that causes severe physical consequences, including pain and sleep disturbance. However, in Ghana, little is known about the experiences of women with cervical cancer. This study explored the physical experiences of women with cervical cancer in Accra, Ghana to help healthcare professionals understand the experiences of their patients and improve the care given.

Methods

This study employed an exploratory descriptive qualitative approach, using purposive sampling technique to select study participants. In-depth interviews lasting between 45 and 90 minutes were conducted face-to-face with 15 women with cervical cancer receiving treatment at a teaching hospital in Ghana to gather information on their physical experiences resulting from the cancer. The interviews were recorded with the participants' consent. Data were transcribed verbatim and subjected to content analysis concurrently with data collection.

Results

Content analysis revealed the following sub-themes within disease-related physical consequences of cervical cancer: pain, impaired sleep patterns, weight loss and gynaecological problems.

Conclusions

The findings of this study suggest that women with cervical cancer experience physical consequences that negatively impact their wellbeing. Healthcare providers should employ a multidisciplinary approach in the management of women with cervical cancer.
Reflection and mental health nursing. Part five: reflection for managers
Authors: Fowler John
Published: April 2020

This series on reflection is examining the place and importance of reflection for all mental health nurses. This article will explore how those two important areas of management and reflection can come together and from a Gestalt view point, be greater than the sum of the parts.
40 years since a psychotic episode. From chaos to calm
Authors: Chadwick Peter
Published: April 2020

Peter Chadwick discusses his life experiences and how different factors helped in his recovery from mental illness.
Mental health nursing: is Rome burning?
Authors: White Edward , Brooker Charles
Published: April 2020

Background/Aims

The recent period of financial austerity, between 2010 and 2020, adversely impacted mental health service provision and raised fundamental questions for mental health nurses. This article aims to identify and discuss present areas of professional concern to mental health nurses in the UK.

Methods

The authors invited submissions from 12 experienced mental health nurses regarding the contemporary circumstances and likely future direction of mental health nursing. Each manuscript was reviewed, and recurrent themes emerged around which an editorial discussion was framed.

Findings

Many issues around service provision have persisted and/or deteriorated over time. The impacts on mental health nursing continue to be largely related to the type of educational preparation required, the size of the workforce and the research activity deemed necessary to strengthen the evidence base of clinical practice.

Conclusions

Mental health nursing faces several challenging issues to address if it is to survive and then to establish the unique professional identity it seeks.
Satisfacción profesional de los educadores sociales: factores de influencia
Authors: Martínez Pérez Alejandro , Lezcano Barbero Fernando
Published: April 2020

INTRODUCCIÓN. El objetivo de este estudio es analizar el grado de autopercepción de la satisfacción laboral de los educadores sociales con su trabajo y los factores que influyen en el mismo. Se ha realizado una introducción acerca del proceso de desarrollo profesional de la educación social en nuestro país y sobre la dificultad para la definición de las funciones y de los campos de trabajo en que el educador social desarrolla su actividad. Posteriormente, se analiza la realidad laboral que abarca el perfil del educador social en la actualidad y se revisan diferentes estudios acerca del concepto de satisfacción laboral y su análisis, centrándose especialmente en aquellos relacionados con la educación y los servicios sociales. MÉTODO. La metodología del estudio es cuantitativa, con un planteamiento descriptivo. Para su realización, se ha utilizado como instrumento un cuestionario en línea, creado ad hoc, autoadministrado y aplicado sobre una muestra de 504 profesionales de las diecisiete comunidades autónomas de España y la ciudad de Ceuta. Los datos se han analizado con el programa SPSS. RESULTADOS. Los resultados muestran un nivel general de la satisfacción laboral autopercibida elevado y lo relacionan con diferentes variables. Se presenta una relación significativa entre satisfacción laboral y las variables de años de experiencia, relación laboral y porcentaje de la jornada; y no significativa en las variables de sexo, edad y entorno de trabajo. DISCUSIÓN. Se establece una discusión comparando los resultados obtenidos con los revisados en trabajos anteriores y se extraen las conclusiones. Se debe tener en cuenta que existen determinados factores laborales que influyen en la satisfacción laboral de los educadores y educadoras sociales. Finalmente, se exponen las limitaciones del trabajo y se realizan propuestas para próximos estudios.
Depletion, intersectionality and the limits of social policy: child carers in Mexico City
Authors: Grugel Jean , Macias Susana , Rai Shirin M.
Published: April 2020

This article makes a dual contribution. First, it adds an intersectional perspective to studies of depletion through social reproduction, examining the depletion experienced by children and adolescents caring for their younger siblings in Mexico City. The depletion that child carers experience is shaped by age, low income, other forms of work in and outside the home, and gender. Second, we explore the limitations of cash transfer welfare programmes by examining their failure to address the needs of children who provide care within the family and show how misperceptions by social policymakers of the experiences of young carers limit the capacity of social policies to make a difference to their well-being. The article underlines the importance of the greater recognition of social reproductive work by poor children and adolescents, and of the intersectional depletion that they experience, both within social policy and in academic research.
Assessment of the nutritive value of corn stover and king grass in complete feed on Ongole steer calves productivity
Authors: Tuturoong Ronny Agustinus Victor , Malalantang Sjenny Sutryaty , Moningkey Sony Arthur Ely
Published: April 2020

Aim: This study aimed to assess the nutritional values of corn stover and king grass (Pennisetum purpupoides) in complete feed on the productivity of male Ongole steer calves.

Materials and Methods: This study was conducted in two steps: Cattle adaptation and data collection. Cattle adaptation was carried out for 2 weeks, and the cattle were fed the experimental feed. The experimental feed was formulated into five combinations: R1 (50% king grass); R2 (12.5% corn stover +7.5% king grass 50% concentrate); R3 (25% corn stover+25% king grass); R4 (37.5% corn stover+12.5% king grass); and R5 (50% corn stover). All experimental feeds were added with 50% concentrate. Data were collected in five intervals, and each interval was of 4 weeks. In every interval, weight gain and digestibility were measured every day, beginning from the 4th week by collecting feces. Dry matter (DM), organic matter (OM), crude protein (CP) digestibility, neutral detergent fiber (NDF), acid detergent fiber (ADF), body weight gain, and feed conversion data were analyzed.

Results: R4 and R5 treatment significantly increased (p<0.05) the feed nutritional value and weight gain of male Ongole steer calves. Interestingly, treatment with R4 had the maximum increase (p<0.05) on the digestibility value of each variable: DM, 68.85%; OM, 71.89%; CP, 73.90%; NDF, 59.10%; ADF, 55.35%; and weight gain, 0.61/gr/day.

Conclusion: R4 treatment found to be the best nutritional value for improving the productivity of male Ongole steer calves.
Normal reference ranges of ocular physiology and sonographic biometry of Latvian Hunting dogs
Authors: Kovaļčuka Līga , Mūrniece Gundega
Published: April 2020

Background and Aim: The Latvian Hunting dog is the only national dog breed in Latvia and so far, there are no data on the important ophthalmological data pertaining to clinical tests and ocular biometry. The aim of this study was to improve the ocular examination and to document normal reference ranges of the globe axial length (AXL), anterior chamber depth (ACD), lens thickness (LT), intraocular pressure (IOP), and Schirmer tear test (STT). Materials and Methods: Sixteen Latvian Hunting dogs (32 eyes) of varying age and sex were included in this study. All dogs underwent an ophthalmic examination followed by tear production (STT) and IOP (TonoVet®) measurements. Biometric examination using A-mode ultrasonography was done under topical corneal anesthesia using 0.5% proparacaine hydrochloride. The eyes were scanned using A-mode ultrasonography with a 10 MHz transducer by transcorneal approach. The reference values of IOP, STT, AXL, ACD, and LT are expressed as mean ± standard deviation (SD). Results: Statistical analysis using the SPSS v.23 and Microsoft Excel 2013 showed no statistically significant differences between the right and left eyes for either of the tests. The mean±SD value of STT and IOP values was 20.9±3.2 mm/min and 17.7±3.2 mmHg, respectively. The mean±SD of the AXL, ACD, and LT obtained by A-mode ultrasound was 2.21±0.1 cm, 0.35±0.1 cm, and 0.42±0.06 cm, respectively. Conclusion: This study documents the normal reference ranges of important ophthalmological clinical tests (IOP and STT) and ocular biometry (AXL, ACD, and LT) in Latvian Hunting dogs.
Női hallgatók számának növelése a mérnöki karon
Authors: Zsótér Brigitta , Gál József
Published: April 2020

A Szegedi Tudományegyetem Mérnöki Karán a 2018. november 1. és 2019. január 31. közötti időszakban kétszer is megrendeztük a „A természettudományos, mérnöki szakok területén a női hallgatók számának növekedése” című eseményt, amely az EFOP-3.4.3-16-2016-00014 azonosító számú, „A Szegedi Tudományegyetem oktatási és szolgáltatási teljesítményének innovatív fejlesztése a munkaerőpiaci és a nemzetközi verseny kihívásaira való felkészülés jegyében” című pályázat AP1 Hallgatói diploma-szerzést segítő szolgáltatások; AP1_MK Lemorzsolódást csökkentő program kifejlesztése az MK-n az MTMI területeken c. alprojekt keretén belül került megvalósításra. A rendezvények célja az volt, hogy a mérnöki tudományokat és a Mérnöki Kar képzéseit népszerűsítse a középiskolás diáklányok körében, ezáltal a mérnökhallgató lányok arányát növelje a jövőben a karon.
Kompetencia és tudásigény felmérése szakmák szerint
Authors: Kis Krisztián , Nagy Valéria , Benkő-Kiss Árpád
Published: April 2020

Kérdőíves felmérést végeztünk a Mérnöki Kar négy alapszakának nappali tagozatos hallgatóinak körében. A felmérés részét képezi annak a négy évre kiterjedő felmérésnek, amelyben a Mérnöki Kar hallgatóinak kompetencia és tudásigényét kívánjuk felmérni. A felmérés célja, hogy a Szegedi Tudományegyetem Mérnöki Kara a (gyakorlatcentrikus) képzéseinek fejlesztéséhez (melynek része pl. az oktatás-módszertan megújítása, illetve a tanulási eredmény alapú szemlélet kialakítása) átfogó képet kapjon a hallgatók kompetenciáiról és tudásigényéről.
Excel VBA függvények kialakítása háromdimenziós vektorok matematikai alkalmazására
Authors: Fabulya Zoltán
Published: April 2020

A háromdimenziós vektorokkal végzett műveletek számítógépes támogatottsága nem megfelelő. A sokak által használt Excel táblázatkezelő program sem rendelkezik testreszabott szolgáltatásokkal a vektorműveletekhez. Ezt a hiányosságot az Excel Visual Basic for Applications nyújtotta lehetőségekkel megszüntethetjük. Kialakíthatunk felhasználói függvényeket, melyekkel kiszámíthatjuk a vektorok matematikai alkalmazási területéhez kapcsolódó eredményeket:

Vektor nagysága, abszolút értéke

Két vektor által bezárt szög, illetve a szög koszinusza

Két vektor skaláris szorzata

Két vektor vektoriális szorzata

Három vektor vegyes szorzata

Az így elkészített függvények a megszokott módon elérhetők lesznek a táblázatkezelő programban, így biztosítva a háromdimenziós vektorok témakörébe tartozó matematikai számítások egyszerű elvégzését.
Hűtőközeg váltás hőszivattyúra gyakorolt hatásának mérési lehetőségei
Authors: Hermanucz Péter , Géczi Gábor , Barótfi István
Published: April 2020

A hőszivattyúkban alkalmazott hűtőközegek többsége jelentősen hozzájárul a globális felmelegedéshez, ezért az utóbbi időben korlátozzák a felhasználható mennyiséget. E korlátozások ösztönzik az úgynevezett természetes hűtőközegek alkalmazását, melyek környezetkárosító hatása minimális. Használatuk új hőszivattyú konstrukciók esetén nem okoz problémát, azonban olyan gépek esetében, melyek műszaki állapota lehetőv é teszi a további üzemelést, nem rendelkezünk kellő ismeretekkel a hűtőközeg váltás berendezésre gyakorolt hatásairól. Jelen munkában be kívánjuk mutatni azon mérési lehetőségeket, melyek egy hűtőközeg váltás hatásainak vizsgálatát teszik lehetővé egy kísérleti berendezésen.
Az OTP Bank Nyrt. vállalati ügyfélkörének elemzése
Authors: Belovecz Mária , Ipacsné Gedei Beáta
Published: April 2020

Az elmúlt időszak gazdasági eseményei után a banki és vállalati szektor is kezd ismételten magára találni, ezért érdemes a bank és a vállalkozások kapcsolatát megvizsgálni. A vizsgálatainkat 2011-2016-os időszakra vetítve lineáris korrelációs együttható vizsgálattal elemezzük, hogy a különböző gazdasági beavatkozások, a jegybanki alapkamat csökkentés, a hitelkamatok változása, vagy a hitelezési feltételek változása hogyan hatnak az OTP Bank vállalati hitelezési- és vállalati betéti állományára. Rámutatunk a piac érzékenységére, arra, hogy a bankok számára jelentős jövedelmezőséget szolgáltató vállalati bázis mennyire rugalmas, milyen gyorsan reagál a piac diktálta körülményekre. Az elemzési módszerek alkalmazásával képet kapunk arról, hogy az egyes vizsgálati szempontok mennyire fontosak a piac elemzett területeinek. Ezáltal látható, hogy milyen területekre kell az OTP Bank-nak a termékkialakítás során koncentrálnia ahhoz, hogy a jövedelmezőségét és ezáltal a magyar piac vezető szerepét hosszú távon is meg tudja tartani.A lineáris korrelációs együttható elemzésénél a mikro- és kisvállalkozói üzletágat és a közép- és nagyvállalati üzletágat külön elemezzük. A mikro- és kisvállalkozói üzletág a vizsgálat minden egyes területén erősebben korrelál a gazdasági eseményekre az adott T időszakban, mint a közép-és nagyvállalati ügyfélkör.Az elemzés során a vállalati betétek változását a jegybanki alapkamat változásával vizsgáljuk. Az elemzés rámutatott arra, hogy a vállalati betétek és a jegybanki alapkamat T időszakra vetítve szoros, ellentétes irányú korrelációban vannak.A hitelállomány-változásának elemzését a hitelkamatok változásával vizsgáljuk. A módszer alkalmazása révén kapott eredmény alapján a mikro- és kisvállalati ügyfélkör erősebb korrelációt mutat T időszakra a vizsgálat elemeivel a közép-és nagyvállalati ügyfélkörnél. A vizsgálat továbbá megerősíti azt, hogy a hitelkamatokkal a vállalatok T időszakra vetítve jóval erősen korrelálnak, mely alátámasztja azt, hogy a kamatokra nagyon érzékeny a vállalati üzletág.
Informatikai alkalmazások és IT-szakemberigény összefüggései a magyarországi vállalkozások körében
Authors: Nagyné Halász Zsuzsanna , Gubán Miklós
Published: April 2020

A vállalkozások számára az információ az egyik legfontosabb erőforrás. Szükséges a szervezeti folyamatok kialakításához, hatékony működtetéséhez, a döntéshozatalhoz, az üzleti környezettel való kapcsolattartáshoz, és a piaci szereplők befolyásolásához is. A piaci és jogszabályi környezet változásai megkövetelik a gyors és rugalmas alkalmazkodást, ami fejlett, hatékony információs rendszerek alkalmazása nélkül nem oldható meg. Az IT-alkalmazások kialakítása és működtetése az informatikai szakemberek feladata. Napjainkban a vállalkozások számára nagy problémát jelent a képzett informatikusok hiánya. Kutatásunk arra keres választ, hogy milyen tényezők befolyásolják a magyarországi társaságok IT-szakember igényét. A vállalkozások összességéből azért erre a célcsoportra esett a választás, mert az önálló vállalkozókra vonatkozó részletes adatbázist nem találtunk. Az informatikai szakemberek feladata az információs rendszerek kialakítása és működtetése, így ebből a nézőpontból vizsgáltuk a témát. Ugyanakkor több tanulmányban igazolták már, hogy az alkalmazott információs rendszer függ a vállalati mérettől. Így kutatásunk célja, hogy kimutassuk a vállalat méret, az alkalmazott információs rendszer és annak igénybevételi módjának hatását a vállalat IT-szakember igényére. Hipotéziseket állítottunk fel, melyeket empirikus kutatással vizsgáltunk. Az adatminta statisztikai elemzése alapjánmegállapítottuk, hogy a vállalat mérete hatással van az alkalmazott információs rendszer típusára, az igénybevétel módjára és az IT-szakemberek iránti keresletre is. Ha azonban arra a kérdésre keresünk választ, hogy a vállalati méret befolyásolja-e, hogy milyen informatikus-igény (rendszerfejlesztő, vagy üzemeltető) merül fel, akkor meg kell állapítanunk a két változó függetlenségét.Az eredmények alapján kimutattuk, hogy a vállalkozásoknál alkalmazott információs rendszer típusa (ERP, vagy sziget rendszerek) hatással van az IT-szakemberigényre. Az igénybe vett IT-szolgáltatás típusa és az informatikus-igény között mintánk alapján nem mutatható ki kapcsolat.Szakirodalmak prognosztizálják a felhő alapú szolgáltatások térhódítását. Így kutatásunkban külön vizsgáltuk ezt a szolgáltatási típust, hatását és megítélését.
Duálgépek használata a dendromassza termelésben
Authors: Horváth Attila László , Vágvölgyi Andrea , Szakálosné Mátyás Katalin
Published: April 2020

Egy Ponsse Buffalo Dual gép vizsgálatára került sor 3 erdőrészletben, hasonló terep- ésállományviszonyok mellett. Az első két esetben harveszter üzemmódban dolgozott a gép, óránkéntiteljesítménye produktív időben meghaladta a 18 ill. a 22 m3-t. Forvarder üzemmódban a gépteljesítménye – produktív időre vetítve – 16 m3/h-ra adódott.
Az eltérő agrotechnikai faktorok hatása a búzaliszt próbacipós és egyéb minőségi paramétereire
Authors: Magyar Zoltán , Pepó Péter , Bakos Tiborné , Gyimes Ernő
Published: April 2020

Kísérleteink során az eltérő elővetemények (csemegekukorica, napraforgó) és a különböző műtrágya szintek (kontroll, N90PK, N150PK) hatását vizsgáltuk három magyar őszi búza genotípusnál. A próbacipós térfogat 705-940 cm3 értékek között változtak. A műtrágyázás szignifikánsan növelte a cipó térfogatot a kontroll mintákhoz képest. Az alaki hányados, VÉ, fehérjetartalom és nedves sikér % mindkét műtrágya dózis esetén szignifikánsan növekedett. A csemegekukorica előveteményes minták valorigráfos értékszáma, nedves sikérje, fehérjetartalma és cipó alaki hányadosa szignifikánsan magasabb volt a napraforgó utániakhoz képest. A fajtahatás x műtrágyázás interakciója statisztikailag bizonyítható mértékben befolyásolta az alaki hányadost és a VÉ-t. A Pearson-féle korrelációs analízis során a műtrágya adag szoros összefüggésben volt a fehérjetartalommal, nedves sikér %-kal, VÉ-vel és közepes korrelációban a cipó alaki hányadossal (0,581**). A cipó térfogat és az alaki hányados közepes összefüggésben volt a VÉ-vel (0,547**), nedves sikér %-kal (0,609**) és fehérjetartalommal (0,663**). Összegezve eredményeinket, a búza próbacipós paramétereit jelentősen befolyásolják a termesztett búzafajták genetikai tulajdonságai, az elővetemény és a műtrágyázási gyakorlat.
Gondolatok a vidékfejlesztés „rendszertanáról”
Authors: Kis Krisztián
Published: April 2020

Az egyre összetettebbé váló világunk teremtette kihívások és az azoknak való megfelelés lehetősége és kényszere rendszerszemléletű gondolkodást és megközelítéseket követel meg a különböző szereplőktől. Nincs ez másként a vidék, a vidéki terek és a vidékfejlesztés esetében sem. Éppen ezért fontos a rendszer összetevői közötti összefüggések felismerése. Jelen írás a vidékre és a vidékfejlesztésre jellemző összetettség fontosabb aspektusait mutatja be a rendszerszemléletű megközelítés „szemüvegén” keresztül. Olyan témák kerülnek bemutatásra, illetve kontextusba helyezésre, amelyek a vidéki terekben zajló területi folyamatok alakításában nagy relevanciával bírnak, így vidékfejlesztési szempontból jelentőségük kiemelkedő. Összességében megállapítható, hogy a hálózatok és a képességek, mint a vidéki terek teljesítményét és sikerességét meghatározó tényezők, nélkülözhetetlen szerepet töltenek be a vidéki területek fejlődésében és a vidékfejlesztés paradigmájának alakításában.
Nanorobots as sensors for cancer microenvironment
Authors: Dasgupta Debayan , Pally Dharma , Saini Deepak , Bhat Ramray , Ghosh Ambarish
Published: April 2020

Malignant cancer cells constantly interact with their surrounding environment and migrate by remodeling the local extracellular matrix (ECM). A quantitative understanding of the remodeled ECM can provide new insights into the process of metastasis. Cells suspended in 3D matrices can mimic many of the physicochemical and mechanical properties of tumors in vivo. Our system is designed to approximate the in vivo histopathological milieu of a malignant breast tumor. Nanorobots can be effective tools for studying cellular biophysics and probing the local rheology of biological systems. Here we demonstrate how magnetically actuated helical nanorobots can probe a 3D tissue co-culture consisting of both cancerous and non-cancerous cells. We find that nanorobots adhere preferentially near cancer cells due to the distinct charge conditions of the cancer-sculpted ECM. The spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cells. However, quantitative measurements showed the adhesive force to increase with metastatic ability of the cell lines. We hypothesized and experimentally confirmed that specific sialic acid linkages related to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. Cell-line specific anisotropy in sialic acid distribution was also discovered by nanorobots. These findings can lead to promising applications in cancer diagnosis and quantification of cancer aggression.
Political Participation in the Digital Age
Authors: Tiemann-Kollipost Julia
Published: April 2020

This book explores the potential of the Internet for enabling new and flexible political participation modes. It meticulously illustrates how the Internet is responsible for citizens' participation practices from being general, high-threshold, temporally constricted, and dependent on physical presence to being topic-centered, low-threshold, temporally discontinuous, and independent from physical presence. With its ethnographic focus on Icelandic and German online participation tools Betri Reykjavík and LiquidFriesland, the book offers plentiful advice for citizens, programmers, politicians, and administrations alike on how to get the most out of online participation formats.
Deradicalization and Formation of Public Attitudes of Islamic Boarding School (Pesantren) in Sukoharjo, Indonesia
Authors: Budiyanto Arkanudin , Subejo Subejo , Maarif Samsul
Published: April 2020

The spread of religious radicalism in Indonesia has pervaded all levels of society without being able to be sorted are rigid. Responding to the situation, the government does the de-radicalization program, included Pesantren. This study aims to identify the communication strategy, internal and external factors in shaping public attitudes of Islamic Boarding School (Pesantren) towards the de-radicalization of religious with quantitative and qualitative approaches. The data collection is done by observation, interviews, questionnaires, and focus group discussions. Quantitative analysis tools using SEM. The results showed that the communication strategy of de-radicalization effect on public attitudes of Islamic Boarding School (Pesantren) through external factors significantly. External factors also influence the public's attitudes of Islamic Boarding School (Pesantren) directly with a strong and significant influence. The communications strategy of de-radicalization also directly affects the public's attitudes of Islamic Boarding School (Pesantren) with weak influence.[Penyebaran radikalisme agama di Indonesia telah merasuki semua lapisan masyarakat tanpa dapat dipilah secara rigid. Merespon situasi tersebut, pemerintah melakukan program deradikalisasi, termasuk di lingkungan Pesantren. Penelitian ini bertujuan untuk mengidentifikasi strategi komunikasi, faktor internal dan eksternal dalam membentuk sikap masyarakat pesantren terhadap deradikalisasi agama dengan pendekatan kuantitatif dan kualitatif. Pengumpulan data dilakukan dengan observasi, wawancara, kuesioner, dan FGD. Alat analisis kuantitatif menggunakan SEM. Hasil penelitian menunjukkan bahwa Strategi komunikasi deradikalisasi berpengaruh terhadap sikap masyarakat pesantren melalui faktor eksternal secara signifikan. Faktor eskternal juga mempengaruhi sikap masyarakat pesantren secara langsung dengan pengaruh yang kuat dan signifikan. Strategi komunikasi deradikalisasi juga berpengaruh langsung terhadap sikap masyarakat pesantren dengan pengaruh yang lemah.]
2020 IGWS Calendar
Authors: Survey Indiana Geological & Water
Published: April 2020

Indiana limestone, known to geologists as the Salem Limestone,is quarried in a narrow 30-mile-long area of south-central Indiana that is alsohome to Indiana University. Gracing up to 75 percent of all limestonebuildings in North America, this stone is known for its particularstrength, durability, and ageless beauty, and clads the nation’s most eminentbuildings, including the Empire State Building, Pentagon, andNational Cathedral.

For more than 100 years, this local stone hasbeen used for buildings on the Bloomingtoncampus. Beginning in 1890 with Maxwell Hall,to 2017 and the completion of Luddy Hall,home of the School of Informatics, Computing,and Engineering, nearly all academic buildingshave been built of Indiana limestone.

Architectural styles on campus span threecenturies. From the highly ornate carvings andpointed arches that define Collegiate Gothicarchitecture to the streamlined Art Deco styleof the early 1900s, the beauty of the campusreflects the skills of local stone artisans. In1979, the National Register of Historic Placesadded the Old Crescent portion of campus toits list to ensure its preservation.

Walking around campus, you’ll see manycarvings on the exteriors of the buildings. Fish,maize, and chemical symbols can be foundon the science buildings on the south side ofcampus, while decorative scrolls of text adornseveral of the art buildings to the east. Themost common carved figure on campus is theowl, a symbol of learning and education, andtwelve are scattered on various buildings.

Today, the history of Indiana’s limestone legacyis preserved in several campus collections andarchives. Most of the photographs used for themosaic on this calendar belong to the IndianaLimestone Photograph Collection. Curated bythe Indiana Geological and Water Survey since2012, this impressive archive consists of morethan 26,000 architectural photos depictingquarries, mills, and buildings from the earlyto mid-1900s. The digitized photographs arestored on IU Libraries Image Collections Online(http://go.iu.edu/16dx).

Other photos in the mosaic are from researchand outreach efforts and the collections of theIndiana Geological and Water Survey.
“Elethia” And “A Sudden Trip Home in Spring”: Alice Walker’s Womanist Response to the Issues of Black People
Authors: ERDEM AYYILDIZ Nilay , KOÇSOY F. Gül
Published: April 2020

Alice Walker (1944-) has brought a new dimension to black feminism with her theory of
womanism, which she explains in In Search of Our Mothers’ Garden (1983).
She aims at achieving universality by extending her struggle to all people
around the world, regardless of race,
gender, and ethnical differences. According to Walker, it requires people to
acknowledge their history, matrilineal descent, and black and
non-black authors’ works inspiring them to struggle. She represents her
womanist understanding in “Elethia” and “A Sudden Trip Home in Spring,” two
short stories in You Can’t Keep A Good Woman Down (1981). The title
character of “Elethia” and Sarah in “A Sudden Trip Home in Spring” face
with their problems and realize how to struggle against them. Thus, analyzing
Walker’s selected stories, the study indicates that she presents a womanist way
out for black people in the racist and sexist society through Elethia and
Sarah.
“Sıradan Hayatlar”ın Psikanalitik Tahlili
Authors: KALE Özlem
Published: April 2020

Jale
Sancak’ın “Sıradan Hayatlar” adlı hikâyesi iç içe geçmiş iki hikâyeden oluşan
çok katmanlı bir yapıya sahiptir. Ana çerçeve, yaşadıklarından yola çıkarak
hikâyesini kurgulayan Güner’i anlatır. Birinci iç hikâye Güner’in yazma
sürecini, ikinci iç hikâye ise Güner’in yarattığı Ömer ve Aslı’nın
yaşadıklarını anlatır. Hikâye, çoklu anlatım, bilinçakışı, üstkurmaca, iç
konuşma, geriye dönüş, imgesel anlatım ve metinlerarasılık gibi tekniklerle
kurgulanmıştır. Olay örgüsü içerisinde serbest çağrışım, aktarım, yansıtma gibi
psikanalitik tekniklerin kullanılabilirliği açısından uygun haller
bulunmaktadır. Aslı, çocukken kendisini tacize uğratan babasını öldürmeyi
planlayan nevrotik bir kişiliktir. Güner’in üstkurmacayla yazdığı iç öykünün
aslında kendi yaşadıklarının bir yansıması olduğu, bilinçaltındaki travmaların
zaman zaman bilinç düzeyine çıkarak hikâye kişilerine yansımasıyla anlaşılır.
Bu çalışmada, hikâyede kullanılan tekniklerin olay örgüsü, kişiler ve mekân
bağlamındaki çağrışımlarından hareketle, Güner ve Aslı’nın psikanalitik
tahlilleri yapılacaktır. Bu yöntem, Freud’un
öğretisi esas alınarak “metin merkezli” okunan hikâyedeki kahramanlara
uygulanacaktır. Güner’in
bu hikâyeyi yazmasındaki temel etkenin katarsis (arınma) olduğunun
kanıtlanmasına çalışılacaktır.
Tüketicilerin Marka Memnuniyeti ve Marka Bağımlılığı İlişkisinde Cinsiyet ve Gelirin Düzenleyici Rolünün İncelenmesi
Authors: DEĞİRMENCİ Bekir , DURMAZ Yakup
Published: April 2020

Marka Bağımlılığı
firmaların faaliyetlerini yürütmesinde ve gelişim kaydederek piyasada aktif rol
oynamada önemli bir güç konumundadır. Müşteri ağı genişledikçe işletmeler
piyasada daha etkin bir şekilde faaliyetlerini yürütme şansı yakalamaktadırlar.
Bu kapsamda çalışma tüketicilerin marka bağımlılığında ürün ve hizmetlerden
duydukları memnuniyet, cinsiyetleri ve gelir durumlarının markaya
bağlılıklarını etkileyip etkilemediği ortaya koymayı amaçlamıştır. Araştırma
Adıyaman İli Besni İlçesinde üniversite okuyan gençler üzerinde yapılmıştır.
Markalı ürün kullanma alışkanlığının gençlerde daha fazla görülmesi araştırma
evreninin şekillenmesinde önemli bir faktör olmuştur. Çalışmada anket yöntemi
kullanılmıştır. Araştırma yöntemi ve hipotezlerin geliştirilmesi için faktör
analizi ve yapısal eşitlik modeli uygulanmıştır. Elde edilen verilere normallik
testi yapılmış sonrasında model geliştirilmiş, hipotezler kurulmuştur.
Korelasyon ve düzenleyici regresyon analizleriyle hipotezlere yönelik elde
edilen bulgular ortaya konmuştur. Elde edilen bulgular incelendiğinde
katılımcıların gelir durumu ve markalı üründen duydukları memnuniyetin marka
bağımlısı olmalarında etkin rol oynağı sonucuna ulaşılmıştır. Firmalar
faaliyetlerini yürütürken mutlaka satış öncesi, satış esnasında ve satış
sonrası hizmetlerle müşteri memnuniyetini ön planda tutmaları gerekmektedir.