bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-Management Behaviors in Adults on Insulin Pump Therapy
Authors: Groat Danielle , Grando Maria Adela , Soni Hiral , Thompson Bithika , Boyle Mary , Bailey Marilyn , Cook Curtiss B.
Published: September 2016

Background:

Successful diabetes management requires behavioral changes. Little is known about self-management behaviors (SMB) in adults on insulin pump (IP) therapy.

Objective:

Analyze and characterize observed common diabetes SMB in adult participants with type 1 diabetes (T1D) using IPs and to correlate behaviors with glycemic outcomes based on participant’s individual glucose targets.

Materials and Methods:

One month of IP data from adults with T1D were downloaded. Computer programs were written to automatically quantify the observed frequency of expected behaviors such as: insulin bolusing, checking blood glucose (BG), and recording carbohydrate intake, and other interactions with the IP.

Results:

Nineteen participants were recruited and 4,249 IP interactions were analyzed to ascertain behaviors. Intersubject variability of adherence to minimally expected behaviors was observed: daily documentation of carbohydrates and BG checks in 76.6 (31.7)% and 60.0 (32.5)%, respectively, and bolusing without consulting the IPBC in 13.0 (16.9)% of delivered boluses, while daily insulin bolus delivery was consistent 96.8 (5.7)%. Higher frequency of adherence to daily behaviors correlated with a higher number of glucose readings at target.

Conclusion:

Results indicate variability in SMB and do not always match recommendations. Case-scenarios based on observed real-life SMB could be incorporated into interviews/surveys to elucidate ways to improve SMB.
Chondroid Syringoma
Authors: Sundling Rebecca A. , So Eric , Logan Daniel B.
Published: September 2016

Chondroid syringoma is a cutaneous sweat gland tumor. Despite its relative rarity, a benign and malignant variant have been described. We present a case report of chondroid syringoma of the foot in a healthy patient. Definitive diagnosis required histopathologic examination, while treatment included wide resection. Surgeons who are presented with a painless, solid nodule in the lower extremities should be cognizant of this neoplasm.

Levels of Evidence: Therapeutic, Level IV: Case report
Fatal cerebral haemorrhage in a hypertensive seven-year-old boy
Authors: Brandtner Herwig , Monticelli Fabio C , Meyer Harald J , Biebl Ariane , Budka Herbert
Published: September 2016

A seven-year-old boy died from autopsy-proven brain haemorrhage due to hypertensive vasculopathy. This emphasizes the importance of early diagnosis and therapy of hypertension in children. Brain haemorrhage is a potentially fatal complication of paediatric hypertension.
Cardiac sarcoma presenting with abdominal pain and mimicking myxoma on echocardiogram
Authors: Diab Mohammad S , Smelt Jeremy , Fletcher Nick , Sarsam Mazin
Published: September 2016

Cardiac sarcoma’s are highly aggressive tumours. Clear resection margins ± autotransplant, followed by chemotherapy, offers the best survival chance. Therefore, frozen section should be preformed when there is ambiguity in diagnosis.
Russia and China
Authors: Oznobishchev Sergey
Published: September 2016

Russia and China have closely interconnected histories and partially coinciding interests in the globalizing world. Disillusioned with the counteraction with the West, especially as a result of the ‘Ukrainian crisis’, Moscow started to construct its ‘own world’, consisting of its own partners. Under this scenario China, with its economic abilities and deep historic ties with the USSR/Russia, looked to be a very privileged partner. But the attempts to change the declared ‘strategic partnership’ between Beijing and Moscow into a closer alliance did not coincide with China’s policy of a ‘peaceful rise’ which was intended to get the maximum possible advantage for Chinese national development from all participants of the world process, without complicating, except with very good reason, its relations with any state. This article analyses the developments in the principal fields of the Russian–Chinese cooperation in the context of the attitudes of the Russian political elite.
Beyond the Surface
Authors: Ravi Anita , Prine Linda , deFiebre Gabrielle , Rubin Susan E.
Published: September 2016

Purpose: To describe rates of and reasons for follow-up among adolescents and adults receiving contraceptive implants in a Federally Qualified Health Center (FQHC). Methods: Retrospective comparison of patient-initiated implant-related contacts during the 6 months postinsertion among adolescents (110) and adults (154) who had implants placed at a FQHC network. Results: Forty percent of adolescents and 26% of adults initiated follow-up ( P = .016). Bleeding changes and discussing removal were the most common reasons for follow-up for both groups. Adolescents (5.5%) and adults (9.0%) had similar removal rates ( P = .348). However, among patients who discussed implant removal, adults were more likely to have removals compared with adolescents ( P = .002). Conclusions: Other FQHCs may anticipate a similar experience to ours, where adolescents may be more likely than adults to initiate implant-related follow up, with removal rates of less than 10% at 6 months. Further study of physician decision making and patient autonomy regarding implantable contraception removal requests is warranted.
Al-Zarnūjī’s Concept of Knowledge (‘Ilm)
Authors: Huda Miftachul , Yusuf Jibrail Bin , Azmi Jasmi Kamarul , Nasir Zakaria Gamal
Published: September 2016

Education is important for every Muslim society as the Prophet made it incumbent on all Muslims. However, the issue of what category of knowledge is permitted for Muslims, the method for imparting this knowledge, and what to impart (content) are arguably the main challenges in Islamic education. Many Muslim scholars have looked at the concept of knowledge from various perspectives. In his monumental work, Ta‘līm Al-Muta‘allim, the classical Muslim scholar, Al-Zarnūjī, expounds the basic principles of education in Islam, which, indeed, have been used as the teaching methodology by many scholars throughout the Muslim world. Using content analysis, this article evaluates the concept of knowledge and its imperatives in Islam from the perspective of Al-Zarnūjī. It was found that Al-Zarnūjī classified knowledge into two main categories. One is perceived as the core of society’s survival and is thus seen as binding on the entire society. This is known as farḍu kifāyah. The other is individually required and is called farḍu ‘ayn. He argues that both should be guided by the Islamic religious values. Therefore, Al-Zarnūjī considers knowledge as a means for advancement and the perfection of the individual and the society both in this world and the hereafter. This makes his concept of knowledge inseparable from the Islamic ethical values. Al-Zarnuji’s contribution to knowledge lies in the packaging and dissemination of the Islamic academic heritage, particularly, the methodology for teaching and learning which is relevant to all the levels of the education ladder.
Epidemiology of Football Injuries in the National Collegiate Athletic Association, 2004-2005 to 2008-2009
Authors: Kerr Zachary Y. , Simon Janet E. , Grooms Dustin R. , Roos Karen G. , Cohen Randy P. , Dompier Thomas P.
Published: September 2016

Background:

Research has found that injury rates in football are higher in competition than during practice. However, there is little research on the association between injury rates and type of football practices and how these specific rates compare with those in competitions.

Purpose:

This study utilized data from the National Collegiate Athletic Association Injury Surveillance System (NCAA ISS) to describe men’s collegiate football practice injuries (academic years 2004-2005 to 2008-2009) in 4 event types: competitions, scrimmages, regular practices, and walkthroughs.

Study Design:

Descriptive epidemiological study.

Methods:

Football data during the 2004-2005 to 2008-2009 academic years were analyzed. Annually, an average of 60 men’s football programs provided data (9.7% of all universities sponsoring football). Injury rates per 1000 athlete-exposures (AEs), injury rate ratios (RRs), 95% CIs, and injury proportions were reported.

Results:

The NCAA ISS captured 18,075 football injuries. Most injuries were reported in regular practices (55.9%), followed by competitions (38.8%), scrimmages (4.4%), and walkthroughs (0.8%). Most AEs were reported in regular practices (77.6%), followed by walkthroughs (11.5%), competitions (8.6%), and scrimmages (2.3%). The highest injury rate was found in competitions (36.94/1000 AEs), followed by scrimmages (15.7/1000 AEs), regular practices (5.9/1000 AEs), and walkthroughs (0.6/1000 AEs). These rates were all significantly different from one another. Distributions of injury location and diagnoses were similar across all 4 event types, with most injuries occurring at the lower extremity (56.0%) and consisting of sprains and strains (50.6%). However, injury mechanisms varied. The proportion of injuries due to player contact was greatest in scrimmages (66.8%), followed by regular practices (48.5%) and walkthroughs (34.9%); in contrast, the proportion of injuries due to noncontact/overuse was greatest in walkthroughs (41.7%), followed by regular practices (35.6%) and scrimmages (21.9%).

Conclusion:

Injury rates were the highest in competitions but then varied by the type of practice event, with higher practice injury rates reported in scrimmage. In addition, greater proportions of injuries were reported in regular practices, and greater proportions of exposures were reported in regular practices and walkthroughs. Efforts to minimize injury in all types of practice events are essential to mitigating injury incidence related to both contact and noncontact.
Efficacy of an mHealth intervention to stimulate physical activity in COPD patients after pulmonary rehabilitation
Authors: Vorrink Sigrid N.W. , Kort Helianthe S.M. , Troosters Thierry , Zanen Pieter , Lammers Jan-Willem J.
Published: September 2016

Physical inactivity in patients with chronic obstructive pulmonary disease (COPD) is associated with poor health status and increased disease burden. The present study aims to test the efficacy of a previously developed mobile (m)Health intervention to improve or maintain physical activity in patients with COPD after pulmonary rehabilitation.

A randomised controlled trial was performed in 32 physiotherapy practices in the Netherlands. COPD patients were randomised into intervention or usual care groups. The intervention consisted of a smartphone application for the patients and a monitoring website for the physiotherapists. Measurements were performed at 0, 3, 6 and 12 months. Physical activity, functional exercise capacity, lung function, health-related quality of life and body mass index were assessed.

157 patients started the study and 121 completed it. There were no significant positive effects of the intervention on physical activity (at 0 months: intervention 5824±3418 steps per weekday, usual care 5717±2870 steps per weekday; at 12 months: intervention 4819±2526 steps per weekday, usual care 4950±2634 steps per weekday; p=0.811) or on the secondary end-points. There was a significant decrease over time in physical activity (p<0.001), lung function (p<0.001) and mastery (p=0.017), but not in functional exercise capacity (p=0.585).

Although functional exercise capacity did not deteriorate, our mHealth intervention did not improve or maintain physical activity in patients with COPD after a period of pulmonary rehabilitation.
Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)
Authors: Cottin Vincent , Bel Elisabeth , Bottero Paolo , Dalhoff Klaus , Humbert Marc , Lazor Romain , Sinico Renato A. , Sivasothy Pasupathy , Wechsler Michael E. , Groh Matthieu , Marchand-Adam Sylvain , Khouatra Chahéra , Wallaert Benoit , Taillé Camille , Delaval Philippe , Cadranel Jacques , Bonniaud Philippe , Prévot Grégoire , Hirschi Sandrine , Gondouin Anne , Dunogué Bertrand , Chatté Gérard , Briault Amandine , Jayne David , Guillevin Loïc , Cordier Jean-François
Published: September 2016

The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail.

In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease.

The study population included 157 patients (mean±sdage 49.4±14.1 years), with a mean±sdblood eosinophil count of 7.4±6.4×109 L−1at diagnosis. There was a mean±sdof 11.8±18.2 years from the onset of asthma to the diagnosis of EGPA, of 1.4±8.4 years from the first onset of peripheral eosinophilia to the diagnosis of EGPA, and of 7.4±6.4 years from EGPA diagnosis to the final visit. Despite inhaled and oral corticosteroid treatment, the severity of asthma increased 3–6 months before the onset of the systemic manifestations. Asthma was severe in 57%, 48%, and 56% of patients at diagnosis, at 3 years, and at the final visit, respectively. Persistent airflow obstruction was present in 38%, 30%, and 46% at diagnosis, at 3 years, and at the final visit, respectively.

In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long-term management and morbidity.
Tilting the lasso by knowledge-based post-processing
Authors: Tharmaratnam Kukatharmini , Sperrin Matthew , Jaki Thomas , Reppe Sjur , Frigessi Arnoldo
Published: September 2016

Background

It is useful to incorporate biological knowledge on the role of genetic determinants in predicting an outcome. It is, however, not always feasible to fully elicit this information when the number of determinants is large. We present an approach to overcome this difficulty. First, using half of the available data, a shortlist of potentially interesting determinants are generated. Second, binary indications of biological importance are elicited for this much smaller number of determinants. Third, an analysis is carried out on this shortlist using the second half of the data.

Results

We show through simulations that, compared with adaptive lasso, this approach leads to models containing more biologically relevant variables, while the prediction mean squared error (PMSE) is comparable or even reduced. We also apply our approach to bone mineral density data, and again final models contain more biologically relevant variables and have reduced PMSEs.

Conclusion

Our method leads to comparable or improved predictive performance, and models with greater face validity and interpretability with feasible incorporation of biological knowledge into predictive models.
InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology
Authors: Peng Jiajie , Li Hongxiang , Liu Yongzhuang , Juan Liran , Jiang Qinghua , Wang Yadong , Chen Jin
Published: September 2016

Background

The Gene Ontology (GO) has been used in high-throughput omics research as a major bioinformatics resource. The hierarchical structure of GO provides users a convenient platform for biological information abstraction and hypothesis testing. Computational methods have been developed to identify functionally similar genes. However, none of the existing measurements take into account all the rich information in GO. Similarly, using these existing methods, web-based applications have been constructed to compute gene functional similarities, and to provide pure text-based outputs. Without a graphical visualization interface, it is difficult for result interpretation.

Results

We present InteGO2, a web tool that allows researchers to calculate the GO-based gene semantic similarities using seven widely used GO-based similarity measurements. Also, we provide an integrative measurement that synergistically integrates all the individual measurements to improve the overall performance. Using HTML5 and cytoscape.js, we provide a graphical interface in InteGO2 to visualize the resulting gene functional association networks.

Conclusions

InteGO2 is an easy-to-use HTML5 based web tool. With it, researchers can measure gene or gene product functional similarity conveniently, and visualize the network of functional interactions in a graphical interface. InteGO2 can be accessed via http://mlg.hit.edu.cn:8089/.
Leray-Schauder-type fixed point theorems in Banach algebras and application to quadratic integral equations
Authors: Khchine Abdelmjid , Maniar Lahcen , Taoudi Mohamed-Aziz
Published: September 2016

In this paper, we present new fixed point theorems in Banach algebras relative to the weak topology. Our fixed point results are obtained under Leray-Schauder-type boundary conditions. These results improve and complement a number of earlier works. As an application, we establish some existence results for a broad class of quadratic integral equations.
Insights from the draft genome of the subsection V (Stigonematales) cyanobacterium Hapalosiphon sp. Strain MRB220 associated with 2-MIB production
Authors: Tan Boon Fei , Te Shu Harn , Boo Chek Yin , Gin Karina Yew-Hoong , Thompson Janelle Renee
Published: September 2016

A non-axenic unialgal culture containing a Subsection V (Stigonematales) cyanobacterium, Hapalosiphon strain MRB 220, was obtained from a benthic freshwater algal mat through multiple transfers following growth in sterile media. Physiological characterization demonstrated the culture was capable of nitrogen-fixation and production of the off flavor compound 2-methylisoborneol (2-MIB). Total DNA isolated from this culture was sequenced using Illumina HiSeq and de novo assembled into contigs. The genome of MRB 220 was separated from co-occurring heterotrophic bacteria using sequence homology and compositional approaches, and its purity was confirmed based on best BLAST hit classification and principle component analysis of the tetranucleotide frequencies of fragmented contigs. The genome of ~7.4 Mbp contains 6,345 protein coding genes with 4,320 of these having functional prediction including predicted pathways for biosynthesis of the secondary metabolite welwitindolinone. Analyses of 16S rRNA gene and whole genome sequence average nucleotide identity indicated close relatedness of MRB 220 to the genera Hapalosiphon and Fischerella within the order Stigonematales. Microscopic examination showed that MRB 220 formed heterocystous branched filaments, thereby supporting identification of strain MRB 220 as a morphospecies of Hapalosiphon. Availability of the draft genome of Hapalosiphon strain MRB 220 enables future work to elucidate the pathway and dynamics for biosynthesis of 2-MIB and other secondary metabolites and understand the ecology and physiology of Stigonematales cyanobacteria in tropical freshwaters.
High quality draft genome sequences of Pseudomonas fulva DSM 17717T, Pseudomonas parafulva DSM 17004T and Pseudomonas cremoricolorata DSM 17059T type strains
Authors: Peña Arantxa , Busquets Antonio , Gomila Margarita , Mulet Magdalena , Gomila Rosa M. , Reddy T. B. K. , Huntemann Marcel , Pati Amrita , Ivanova Natalia , Markowitz Victor , García-Valdés Elena , Göker Markus , Woyke Tanja , Klenk Hans-Peter , Kyrpides Nikos , Lalucat Jorge
Published: September 2016

Pseudomonas has the highest number of species out of any genus of Gram-negative bacteria and is phylogenetically divided into several groups. The Pseudomonas putida phylogenetic branch includes at least 13 species of environmental and industrial interest, plant-associated bacteria, insect pathogens, and even some members that have been found in clinical specimens. In the context of the Genomic Encyclopedia of Bacteria and Archaea project, we present the permanent, high-quality draft genomes of the type strains of 3 taxonomically and ecologically closely related species in the Pseudomonas putida phylogenetic branch: Pseudomonas fulva DSM 17717T, Pseudomonas parafulva DSM 17004T and Pseudomonas cremoricolorata DSM 17059T. All three genomes are comparable in size (4.6–4.9 Mb), with 4,119–4,459 protein-coding genes. Average nucleotide identity based on BLAST comparisons and digital genome-to-genome distance calculations are in good agreement with experimental DNA-DNA hybridization results. The genome sequences presented here will be very helpful in elucidating the taxonomy, phylogeny and evolution of the Pseudomonas putida species complex.
The physical and physiological effects of vacuum massage on the different skin layers: a current status of the literature
Authors: Moortgat Peter , Anthonissen Mieke , Meirte Jill , Van Daele Ulrike , Maertens Koen
Published: September 2016

Vacuum massage is a non-invasive mechanical massage technique performed with a mechanical device that lifts the skin by means of suction, creates a skin fold and mobilises that skin fold. In the late 1970s, this therapy was introduced to treat traumatic or burn scars.

Although vacuum massage was invented to treat burns and scars, one can find very little literature on the effects of this intervention. Therefore, the aim of this review is to present an overview of the available literature on the physical and physiological effects of vacuum massage on epidermal and dermal skin structures in order to find the underlying working mechanisms that could benefit the healing of burns and scars. The discussion contains translational analysis of the results and provides recommendations for future research on the topic.

An extended search for publications was performed using PubMed, Web of Science and Google Scholar. Two authors independently identified and checked each study against the inclusion criteria.

Nineteen articles were included in the qualitative synthesis. The two most reported physical effects of vacuum massage were improvement of the tissue hardness and the elasticity of the skin. Besides physical effects, a variety of physiological effects are reported in literature, for example, an increased number of fibroblasts and collagen fibres accompanied by an alteration of fibroblast phenotype and collagen orientation. Little information was found on the decrease of pain and itch due to vacuum massage.

Although vacuum massage initially had been developed for the treatment of burn scars, this literature review found little evidence for the efficacy of this treatment. Variations in duration, amplitude or frequency of the treatment have a substantial influence on collagen restructuring and reorientation, thus implying possible beneficial influences on the healing potential by mechanotransduction pathways. Vacuum massage may release the mechanical tension associated with scar retraction and thus induce apoptosis of myofibroblasts. Suggestions for future research include upscaling the study design, investigating the molecular pathways and dose dependency, comparing effects in different stages of repair, including evolutive parameters and the use of more objective assessment tools.
Situating Second-Year Success: Understanding Second-Year STEM Experiences at a Liberal Arts College
Authors: Gregg-Jolly Leslie , Swartz Jim , Iverson Ellen , Stern Joyce , Brown Narren , Lopatto David
Published: September 2016

Challenges particular to second-year students have been identified that can impact persistence in science, technology, engineering, and mathematics (STEM) fields. We implemented a program to improve student success in intermediate-level science courses by helping students to feel they belonged and could succeed in STEM. We used survey measures of perceptions and attitudes and then qualitative measures to characterize the impact of support strategies, including peer mentoring, a second-year science student retreat, learning and advising support resources, and department-specific activities. Analysis of registration and transcript information revealed underperformance by students of color (SOC) and first-generation (FG) students in 200-level science courses. Comparison of these data before and during programming revealed significant improvement in success rates of these students in 200-level biology and chemistry courses, but success rates of SOC and FG students remain lower than the overall rate for 200-level science courses. Contemporaneous with the program, qualitative and quantitative measures of student attitudes revealed a high level of belongingness and support. The results suggest that a focus on students’ metacognition about their own abilities and strategic knowledge of how to succeed may be a fruitful direction for future research.
Learning to Thrive: Building Diverse Scientists’ Access to Community and Resources through the BRAINS Program
Authors: Margherio Cara , Horner-Devine M. Claire , Mizumori Sheri J. Y. , Yen Joyce W.
Published: September 2016

BRAINS: Broadening the Representation of Academic Investigators in NeuroScience is a National Institutes of Health–funded, national program that addresses challenges to the persistence of diverse early-career neuroscientists. In doing so, BRAINS aims to advance diversity in neuroscience by increasing career advancement and retention of post-PhD, early-career neuroscientists from underrepresented groups (URGs). The comprehensive professional development program is structured to catalyze conversations specific to URGs in neuroscience and explicitly addresses factors known to impact persistence such as a weak sense of belonging to the scientific community, isolation and solo status, inequitable access to resources that impact career success, and marginalization from informal networks and mentoring relationships. While we do not yet have data on the long-term impact of the BRAINS program on participants’ career trajectory and persistence, we introduce the BRAINS program theory and report early quantitative and qualitative data on shorter-term individual impacts within the realms of career-advancing behaviors and career experiences. These early results suggest promising, positive career productivity, increased self-efficacy, stronger sense of belonging, and new perspectives on navigating careers for BRAINS participants. We finish by discussing recommendations for future professional development programs and research designed to broaden participation in the biomedical and life sciences.
From the NSF: The National Science Foundation’s Investments in Broadening Participation in Science, Technology, Engineering, and Mathematics Education through Research and Capacity Building
Authors: James Sylvia M. , Singer Susan R.
Published: September 2016

The National Science Foundation (NSF) has a long history of investment in broadening participation (BP) in science, technology, engineering, and mathematics (STEM) education. A review of past NSF BP efforts provides insights into how the portfolio of programs and activities has evolved and the broad array of innovative strategies that has been used to increase the participation of groups underrepresented in STEM, including women, minorities, and persons with disabilities. While many are familiar with these long-standing programmatic efforts, BP is also a key component of NSF’s strategic plans, has been highlighted in National Science Board reports, and is the focus of ongoing outreach efforts. The majority of familiar BP programs, such as the Louis Stokes Alliances for Minority Participation (now 25 years old), are housed in the Directorate for Education and Human Resources. However, fellowship programs such as the Graduate Research Fellowships and Postdoctoral Research Fellowships under the Directorate for Biological Sciences (and parallel directorates in other STEM disciplines) are frequently used to address underrepresentation in STEM disciplines. The FY2016 and FY2017 budget requests incorporate funding for NSF INCLUDES, a new cross-agency BP initiative that will build on prior successes while addressing national BP challenges. NSF INCLUDES invites the use of innovative approaches for taking evidence-based best practices to scale, ushering in a new era in NSF BP advancement.
Outcomes and Processes in the Meyerhoff Scholars Program: STEM PhD Completion, Sense of Community, Perceived Program Benefit, Science Identity, and Research Self-Efficacy
Authors: Maton Kenneth I. , Beason Tiffany S. , Godsay Surbhi , Sto. Domingo Mariano R. , Bailey TaShara C. , Sun Shuyan , Hrabowski Freeman A.
Published: September 2016

Previous research has shown that the Meyerhoff Scholars Program at the University of Maryland, Baltimore County, is an effective intervention for high-achieving underrepresented minority (URM) students; African-American Meyerhoff students are significantly more likely to enter science, technology, engineering, and mathematics (STEM) PhD programs than comparison students. The first of two studies in this report extends the prior research by examining levels of PhD completion for Meyerhoff (N = 479) versus comparison sample (N = 249) students among the first 16 cohorts. Entering African-American Meyerhoff students were 4.8 times more likely to complete STEM PhDs than comparison sample students. To enhance understanding of potential mechanisms of influence, the second study used data from the 22nd (Fall 2010) to 25th (Fall 2013) cohorts (N = 109) to test the hypothesis that perceived program benefit at the end of freshman year would mediate the relationship between sense of community at the end of Summer Bridge and science identity and research self-efficacy at the end of sophomore year. Study 2 results indicated that perceived program benefit fully mediated the relationship between sense of community and both criterion measures. The findings underscore the potential of comprehensive STEM intervention programs to enhance PhD completion, and suggest mechanisms of influence.
Neutrophils can disarm NK cell response through cleavage of NKp46
Authors: Valayer Alexandre , Brea Deborah , Lajoie Laurie , Avezard Leslie , Combes-Soia Lucie , Labas Valerie , Korkmaz Brice , Thibault Gilles , Baranek Thomas , Si-Tahar Mustapha
Published: September 2016

Polymorphonuclear neutrophils (PMNs) can contribute to the regulation of the host immune response by crosstalk with innate and adaptive leukocytes, including NK cells. Mechanisms by which this immunoregulation process occurs remain incompletely understood. Here, we focused on the effect of human neutrophil-derived serine proteases on NKp46, a crucial activating receptor expressed on NK cells. We used flow cytometry, Western blotting, and mass spectrometry (MS) analysis to reveal that cathepsin G [CG; and not elastase or proteinase 3 (PR3)] induces a time- and concentration-dependent, down-regulatory effect on NKp46 expression through a restricted proteolytic mechanism. We also used a functional assay to demonstrate that NKp46 cleavage by CG severely impairs NKp46-mediated responses of NK cells, including IFN-γ production and cell degranulation. Importantly, sputa of cystic fibrosis (CF) patients, which have high concentrations of CG, also alter NKp46 on NK cells. Hence, we have identified a new immunoregulatory mechanism of neutrophils that proteolytically disarms NK cell responses.
Acoustic wave propagation in tilted transversely isotropic media: Incorporating topography
Authors: Shragge Jeffrey
Published: September 2016

Simulating two-way acoustic wavefield propagation directly from a free-surface boundary in the presence of topography remains a computational challenge for applications of reverse time migration (RTM) or full-waveform inversion (FWI). For land-seismic settings involving heavily reworked geology (e.g., fold and thrust belts), two-way wavefield propagation operators should also handle commonly observed complex anisotropy including tilted transversely isotropic (TTI) media. To address these issues, I have extended a system of coupled partial differential equations used to model 3D acoustic TTI wave propagation in Cartesian coordinates to more generalized 3D geometries, including a deformed computational mesh with a domain boundary conformal to free-surface topography. A generalized curvilinear transformation is used to specify a system of equations governing 3D acoustic TTI wave propagation in the “topographic” coordinate system. The developed finite-difference time-domain numerical solution adapts existing Cartesian TTI operators to this more generalized geometry with little additional computational overhead. Numerical evaluations illustrate that 2D and 3D impulse responses are well-matched to those simulated on Cartesian meshes and analytic traveltimes for homogeneous elliptical TTI media. Accordingly, these generalized acoustic TTI propagators and their numerical adjoints are useful for undertaking most RTM or FWI applications using computational domains conforming to free-surface topography.
Inhibition of cargo export at ER exit sites and the trans-Golgi network by the secretion inhibitor FLI-06
Authors: Yonemura Yoji , Li Xiaolin , Müller Katja , Krämer Andreas , Atigbire Paul , Mentrup Torben , Feuerhake Talitha , Kroll Torsten , Shomron Olga , Nohl Richard , Arndt Hans-Dieter , Hoischen Christian , Hemmerich Peter , Hirschberg Koret , Kaether Christoph
Published: September 2016

Export out of the endoplasmic reticulum (ER) involves the Sar1 and COPII machinery acting at ER exit sites (ERES). Whether and how cargo proteins are recruited upstream of Sar1 and COPII is unclear. Two models are conceivable, a recruitment model where cargo is actively transported through a transport factor and handed over to the Sar1 and COPII machinery in ERES, and a capture model, where cargo freely diffuses into ERES where it is captured by the Sar1 and COPII machinery. Using the novel secretion inhibitor FLI-06, we show that recruitment of the cargo VSVG to ERES is an active process upstream of Sar1 and COPII. Applying FLI-06 before concentration of VSVG in ERES completely abolishes its recruitment. In contrast, applying FLI-06 after VSVG concentration in ERES does not lead to dispersal of the concentrated VSVG, arguing that it inhibits recruitment to ERES as opposed to capture in ERES. FLI-06 also inhibits export out of the trans-Golgi network (TGN), suggesting that similar mechanisms might orchestrate cargo selection and concentration at the ER and TGN. FLI-06 does not inhibit autophagosome biogenesis and the ER-peroxisomal transport route, suggesting that these rely on different mechanisms.
Fiducial marker guided prostate radiotherapy: a review
Authors: O'Neill Angela G M , Jain Suneil , Hounsell Alan R , O'Sullivan Joe M
Published: September 2016

Image-guided radiotherapy (IGRT) is an essential tool in the accurate delivery of modern radiotherapy techniques. Prostate radiotherapy positioned using skin marks or bony anatomy may be adequate for delivering a relatively homogeneous whole-pelvic radiotherapy dose, but these surrogates are not reliable when using reduced margins, dose escalation or hypofractionated stereotactic radiotherapy. Fiducial markers (FMs) for prostate IGRT have been in use since the 1990s. They require surgical implantation and provide a surrogate for the position of the prostate gland. A variety of FMs are available and they can be used in a number of ways. This review aimed to establish the evidence for using prostate FMs in terms of feasibility, implantation procedures, types of FMs used, FM migration, imaging modalities used and the clinical impact of FMs. A search strategy was defined and a literature search was carried out in Medline. Inclusion and exclusion criteria were applied, which resulted in 50 articles being included in this review. The evidence demonstrates that FMs provide a more accurate surrogate for the position of the prostate than either external skin marks or bony anatomy. A combination of FM alignment and soft-tissue analysis is currently the most effective and widely available approach to ensuring accuracy in prostate IGRT. FM implantation is safe and well tolerated. FM migration is possible but minimal. Standardization of all techniques and procedures in relation to the use of prostate FMs is required. Finally, a clinical trial investigating a non-surgical alternative to prostate FMs is introduced.
Venous thromboembolism in the elderly
Authors: Ploenes C.
Published: September 2016

Old age is an independent risk factor of venous thromboembolism. Nevertheless initial symptoms are often attributed to existing cardiac or pulmonary comorbidity. Once deep thromboembolism (DTE) is in focus, the synopsis of clinical findings and anamnestic clues help to take further steps to establish or rule out the diagnosis (e.g. Wells score). Treatment consists in oral anticoagulation, either by vitamin-k-antagonists or by direct oral anticoagulants (“DOACs”). Strict compliance of patients or main caregivers is essential in both cases. Simultaneous medication of platelet-inhibitingor nonsteroidal anti-inflammatory drugs – often unknown self medication – results in a raised bleeding risk and should be avoided. If longterm anticoagulation is mandatory, a strategy of sequential dose-reduced anticoagulation can be considered, especially in the case of increased bleeding-risk. Systemic fibrinolysis of pulmonary embolism goes along with a very high bleeding risk in old age and should be performed only in case of vital circulatory depression or failure.
Surgical repair of a popliteal vein aneurysm to prevent thromboembolic complications
Authors: Mühlberger D. , Regeniter P. , Mumme A. , Hummel T. , Burkert B.
Published: September 2016

The case reported here involves a 72-year-old female patient with right-sided popliteal vein aneurysm, which became apparent during follow-up ultrasound scanning after deep venous thrombosis of the left leg with pulmonary embolism. Due to the size of the aneurysm, the decision was made to perform surgery. The aneurysm was tangentially resected by means of plication. Aneurysms of the deep venous system carry a considerable risk of a thromboembolic event and therefore require treatment, even when they are asymptomatic. Surgical treatment of an aneurysm of the deep leg veins is a safe and low-risk procedure for the prevention of pulmonary embolism.
The post-thrombotic syndrome
Authors: Pannier F. , Rabe E.
Published: September 2016

Post-thrombotic syndrome (PTS) is a common complication of deep vein thrombosis (DVT) in the legs. Risk factors include recurrent ipsilateral DVT, proximal vein involvement, persistent occlusion of the deep venous system, obesity, and pre-existing chronic venous disease. Compression therapy, exercise, and weight loss, as well as effective anticoagulation of the initial DVT and secondary thromboprophylaxis, are all important aspects in the prevention and treatment of post-thrombotic syndrome.
Opportunities and considerations for visualising neuroimaging data on very large displays
Authors: Wall Matthew B. , Birch David , Yong May Y.
Published: September 2016

Neuroimaging experiments can generate impressive volumes of data and many images of the results. This is particularly true of multi-modal imaging studies that use more than one imaging technique, or when imaging is combined with other assessments. A challenge for these studies is appropriate visualisation of results in order to drive insights and guide accurate interpretations. Next-generation visualisation technology therefore has much to offer the neuroimaging community. One example is the Imperial College London Data Observatory; a high-resolution (132 megapixel) arrangement of 64 monitors, arranged in a 313 degree arc, with a 6 metre diameter, powered by 32 rendering nodes. This system has the potential for high-resolution, large-scale display of disparate data types in a space designed to promote collaborative discussion by multiple researchers and/or clinicians. Opportunities for the use of the Data Observatory are discussed, with particular reference to applications in Multiple Sclerosis (MS) research and clinical practice. Technical issues and current work designed to optimise the use of the Data Observatory for neuroimaging are also discussed, as well as possible future research that could be enabled by the use of the system in combination with eye-tracking technology.
Bayesian Estimation of a Dynamic Model of Two-Sided Markets: Application to the U.S. Video Game Industry
Authors: Zhou Yiyi
Published: September 2016

This paper develops and estimates a structural model of two-sided markets with durable platform intermediaries and affiliated products. It models buyers’ purchase decisions of platforms and affiliated products and sellers’ decisions of price setting and entry, accounting for the dynamic interaction between the two distinct groups of platform participants. To estimate the proposed model, this paper develops a Bayesian Markov chain Monte Carlo estimation approach that incorporates nonparametric approximation and interpolation methods. The proposed model and estimation method are applied to the 32/64-bit generation of the U.S. video game industry. The results of counterfactual experiments show that the dynamic behavior of platform participants has significant impacts on platform adoption and the affiliated product market, and that a failed platform could have survived if it had priced the two sides properly in a dynamic two-sided market environment.

This paper was accepted by Matthew Shum, marketing.
Underpinnings of User Participation in Service Provider–Hosted Online Communities
Authors: Kaur Puneet
Published: September 2016

The recent emergence of social media-based brand communities is seen as an effective channel for practicing user-centric service innovation. However, user participation is the major hurdle in their sustainability. Despite the growing popularity of these brand communities, there has been only limited research examining the factors affecting user intention to continue using these communities. Teenagers represent an important demographic group, not only as the dominant users, but also in their value and potential in contributing toward successful business. To date, no previous research has investigated the participation behaviour of teenagers in these communities. To address this research gap, the present study examines the factors affecting teenagers’ intention to continue participating in Facebook-based brand communities. The roles of social and individual factors in the formulation of their attitudes to participation are examined. The relationship between users’ attitudes, activity levels, and continuation intentions are explored. The study findings suggest that self-efficacy, hedonic motivation, reciprocal benefit, and social influence have a positive impact on user attitude. Among these, self-efficacy has the strongest influence. Furthermore, attitude, continuation intention, and activity levels are significantly related. The findings have implications for organisations intending to use social media-based brand communities to practice user-centric service innovation.
Triadic Value Propositions: When It Takes More Than Two to Tango
Authors: Kowalkowski Christian , Kindström Daniel , Carlborg Per
Published: September 2016

Value propositions are reciprocal resource-integration promises and value alignment mechanisms operating to and from actors seeking an equitable exchange. In a business triad, any change in the relationship between two actors also affects relationships with the third actor, influencing resource integration and value creation at the value constellation level. This study of the development of a triadic value proposition analyzes how the discontinuous effects of a new service initiative alter the relationships among actors in a manufacturer–dealer–user triad. A qualitative empirical inquiry examines a 10-year process, in which a leading industry incumbent enters the service business by crafting a triadic value proposition. As the value proposition evolves over time, the network ties—and thus the interdependence among manufacturer, dealer, and user—strengthen. The findings offer firms a better understanding of how to involve and collaborate with key actors to initiate discontinuous changes at the firm and network levels. These insights are particularly timely in light of the difficulties that product firms face when intermediaries are decisive for the success of their service-led growth initiatives.
Interactional Service Innovation with Social Media Users
Authors: Uratnik Miha
Published: September 2016

The pervasive availability of social media is changing user interaction in service innovation. However, we lack information on how to leverage interactional service innovation with social media. This paper draws from an analytical framework constructed according to mixed qualitative research, deriving a model and functions of its agents in social media innovation. The findings indicate that organizations interact with the social media and reduce diseconomies of scope; however, they also codestroy value. Hence, we explain how companies leverage sustainable innovation with social media users in the co-production and co-creation of value. We conclude the findings and results with the theoretical propositions, and the conclusion follows an outline of the contributions, future research, and managerial implications.
The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty
Authors: Yuan Z. F. , Yin H. , Ma W. P. , Xing D. L.
Published: September 2016

Objectives

Tranexamic acid (TXA) is an antifibrinolytic agent used as a blood-sparing technique in total knee arthroplasty (TKA), and is routinely administered by intravenous (IV) or intra-articular (IA) injection. Recently, a novel method of TXA administration, the combined IV and IA application of TXA, has been applied in TKA. However, the scientific evidence of combined administration of TXA in TKA is still meagre. This meta-analysis aimed to investigate the efficacy and safety of combined IV and IA TXA in patients undergoing TKA.

Materials and Methods

A systematic search was carried out in PubMed, the Cochrane Clinical Trial Register (Issue12 2015), Embase, Web of Science and the Chinese Biomedical Database. Only randomised controlled trials (RCT) evaluating the efficacy and safety of combined use TXA in TKA were identified. Two authors independently identified the eligible studies, extracted data and assessed the methodological quality of included studies. Meta-analysis was conducted using Review Manager 5.3 software.

Results

A total of ten RCTs (1143 patients) were included in this study. All the included studies were randomised and the quality of included studies still needed improvement. The results indicated that, compared with either placebo or the single-dose TXA (IV or IA) group, the combination of IV and IA TXA group had significantly less total blood loss, hidden blood loss, total drain output, a lower transfusion rate and a lower drop in haemoglobin level. There were no statistically significant differences in complications such as wound infection and deep vein thrombosis between the combination group and the placebo or single-dose TXA group.

Conclusions

Compared with placebo or the single-dose TXA, the combined use of IV and IA TXA provided significantly better results with respect to all outcomes related to post-operative blood loss without increasing the risk of thromboembolic complications in TKA. Cite this article: Z. F. Yuan, H. Yin, W. P. Ma, D. L. Xing. The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty: combined tranexamic acid for TKA. Bone Joint Res 2016;5:353–361. DOI: 10.1302/2046-3758.58.BJR-2016-0001.R2.