bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy
Authors: MacLeod A. Kenneth , Lin De , Huang Jeffrey T.–J. , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: February 2018

Purpose: Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non–small cell lung cancer. A full understanding of its disposition and capacity for interaction with other medications will facilitate its effective use as a single agent and in combination therapy.

Experimental Design: Recombinant cytochrome P450s and liver microsomal preparations were used to identify novel pathways of osimertinib metabolism in vitro. A panel of knockout and mouse lines humanized for pathways of drug metabolism were used to establish the relevance of these pathways in vivo.

Results: Although some osimertinib metabolites were similar in mouse and human liver samples there were several significant differences, in particular a marked species difference in the P450s involved. The murine Cyp2d gene cluster played a predominant role in mouse, whereas CYP3A4 was the major human enzyme responsible for osimertinib metabolism. Induction of this enzyme in CYP3A4 humanized mice substantially decreased circulating osimertinib exposure. Importantly, we discovered a further novel pathway of osimertinib disposition involving CPY1A1. Modulation of CYP1A1/CYP1A2 levels markedly reduced parent drug concentrations, significantly altering metabolite pharmacokinetics (PK) in humanized mice in vivo.

Conclusions: We demonstrate that a P450 enzyme expressed in smokers' lungs and lung tumors has the capacity to metabolise osimertinib. This could be a significant factor in defining the outcome of osimertinib treatment. This work also illustrates how P450-humanized mice can be used to identify and mitigate species differences in drug metabolism and thereby model the in vivo effect of critical metabolic pathways on anti-tumor response. Clin Cancer Res; 24(9); 2138–47. ©2018 AACR.
Psychosocial Pretreatment Predictors of Weight Control: A Systematic Review Update
Authors: Carraça Eliana V. , Santos Inês , Mata Jutta , Teixeira Pedro J.
Published: February 2018

Objective: Systematically identifying pretreatment characteristics that predict successful weight management is important to improve intervention efficacy and clinical practice. This study provides a comprehensive update of a 2005 review on pretreatment predictors of successful weight management. Methods: Results of 37 recent original studies from peer-reviewed journals were merged with the results from the 2005 review. A critical appraisal of the 66 studies included was provided, and meta-analyses were performed when feasible. Results: Fewer previous weight loss attempts were the most consistent pretreatment predictor of successful weight management, although with a small effect size. Importantly, several variables were identified as non-significant predictors of weight loss, showing trivial effects (e.g., eating self-efficacy). Many psychosocial factors remain too little studied to allow reliable conclusions regarding their predictive value. Conclusion: Previous dieting attempts were identified as the soundest predictor of successful weight management. Several factors, previously considered barriers to successful weight management and now identified as non-predictors, require more investigation given the limitations identified in this review. Importantly, due to a comparably thin empirical basis for many predictors, further research is essential to move the field forward. Implications of the current state of research and necessary steps to improve intervention efficacy and clinical practice are discussed
Should We Use Sentence- or Text-Level Tasks to Measure Oral Language Proficiency in Year-One Students following Whole-Class Intervention?
Authors: Lennox Maria , Westerveld Marleen F. , Trembath David
Published: February 2018

Aims: To compare students’ oral language proficiency on sentence- versus text-level tasks at school entry and following tier 1 intervention in their first year of formal schooling. Methods: 104 students participated in this study. Participants were part of a broader longitudinal study and were enrolled at 3 low socioeconomic, linguistically diverse Australian primary schools. Tasks were administered to all students at the beginning and end of the school year. Performance on the sentence-level task, the Renfrew Action Picture Test (RAPT), was analysed for information and grammar as per the test manual. Performance on the text-level task, the Profile of Oral Narrative Ability, was analysed for measures of story length, mean length of utterance, grammatical accuracy, number of different words, and story quality. Results: Results showed that both tasks are sensitive to measure progress following tier 1 intervention. However, RAPT concern status was not related to oral narrative concern status. Furthermore, if only the RAPT task had been used, between 11 and 21% of students performing below expectations in oral narrative would not have been identified. Conclusion: It is recommended that the assessment of oral language proficiency of students from culturally diverse, low socioeconomic backgrounds goes beyond the sentence level and includes an oral narrative retell task.
Asymmetric Acral Spared Phenomenon Related to Systemic Anticancer Therapies
Authors: Baran Robert , Robert Caroline , Sibaud Vincent
Published: February 2018

We have observed three patients on anticancer therapies presenting with asymmetric acral spared phenomenon and found six identical cases in the literature. All of them had common features, an alteration of the peripheral nerves affecting a limb unilaterally that was spared by a hand-foot syndrome or hand-foot skin reaction. A drug-induced neurotropic effect sounds logical for developing such alterations with specific chemotherapeutic agents (taxanes, cap­ecitabine), while we have not found good explanations concerning the multikinase inhibitor sorafenib nor the topo isomerase inhibitor adriamycin. Nevertheless, we know that clinical manifestations of many inflammatory diseases need intact neural components.
A Bile Duct Stone Formation around a Fish Bone as a Nidus after Pancreatoduodenectomy
Authors: Sakakida Tomoki , Sato Hideki , Doi Toshifumi , Kawakami Takumi , Nakatsugawa Yoshikazu , Nishimura Ken , Yamada Shinya , Fujii Hideki , Tomatsuri Naoya , Okuyama Yusuke , Kimura Hiroyuki , Yoshida Norimasa
Published: February 2018

We report a rare case of bile duct stone formation around an ingested fish bone as a nidus after pancreatoduodenectomy. A 78-year-old woman was admitted to our department for fever and epigastric pain. Abdominal computed tomography revealed an elongated bile duct stone containing a linearly shaped foreign body of bone density. Enteroscopic lithotomy was performed using single balloon enteroscopy to safely remove the stone and foreign body from the bile duct. The foreign body was determined to be a fish bone by pathological examination and component analysis.
Common Variable Immunodeficiency-Associated Inflammatory Enteropathy: The New Era of Biological Therapy
Authors: Arieira Cátia , Dias de Castro Francisca , Moreira Maria João , Cotter José
Published: February 2018

Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient’s condition is currently clinically improved with no complications due to biological therapy.
Effect of the Opioid Crisis on the Donor Pool for Kidney Transplantation: An Analysis of National Kidney Deceased Donor Trends from 2010–2016
Authors: Chute Donald F. , Sise Meghan E.
Published: February 2018

Background: The opioid crisis has led to a dramatic increase in the number of drug overdose deaths in the United States. Little is known about the effect of the opioid crisis on the kidney transplant donor pool, particularly on hepatitis C virus (HCV)-infected donors. Methods: This is a retrospective analysis of the data from the Organ Procurement and Transplantation Network from 2010 to 2016. We determined the changes in characteristics of kidney transplant donors and evaluated which changes may be directly related to the opioid crisis. Results: Between 2010 and 2016, we found a 26% increase in overall donors, including a 277% increase in the number of donors who died from drug overdose. Nineteen percent of donors who died of drug overdose had HCV infection. Donors who die from drug overdose and donors with HCV infection are younger, less likely to have diabetes or hypertension, and have favorable kidney donor profile index scores compared to average donors. Despite these favorable characteristics, HCV-infected donors appear to be notably underutilized, with substantially lower kidneys per donor being transplanted compared to HCV uninfected donors. Conclusion: The opioid crisis in the United States has substantially altered the kidney donor pool. Strategies to increase utilization of all potentially viable kidneys for transplant are needed, particularly in this era of new, highly effective, direct-acting antiviral therapy for HCV infection.
Nephrocalcinosis in Amelogenesis Imperfecta Caused by the FAM20A Mutation
Authors: Koruyucu Mine , Seymen Figen , Gencay Genco , Gencay Koray , Tuna Elif Bahar , Shin Teo Jeon , Hyun Hong-Keun , Kim Young-Jae , Kim Jung-Wook
Published: February 2018

Background/Aims: Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether AI patients with known ­FAM20A mutations also have nephrocalcinosis. Methods: Complete oral and radiological examinations were performed for all participating family members. Renal examinations were performed using ultrasound. Results: The teeth were evaluated for severe loss, and multiple eruption failures were evident from the clinical and radiological examinations. Unexpected extensive and fast crown resorption was found by radiological examination. Renal ultrasound revealed bilateral nephrocalcinosis in both affected individuals. Recessive FAM20A mutations can cause nephrocalcinosis in addition to the oral phenotype. Conclusion: AI patients with similar clinical phenotypes and FAM20A mutations should be examined for nephropathy even if they lack pertinent symptoms. Nephrology referral is warranted for patients who have clinical phenotypes related to AI-gingival fibromatosis even if they are not symptomatic.
The Predictive Value of Amplitude-Integrated Electroencephalography in Preterm Infants for IQ and Other Neuropsychological Outcomes at Early School Age
Authors: Middel Richelle G. , Brandenbarg Nicolien , Van Braeckel Koenraad N.J.A. , Bos Arend F. , Ter Horst Hendrik J.
Published: February 2018

Background: Amplitude-integrated electroencephalography (aEEG) is used increasingly in neonatal intensive care and seems helpful in predicting outcomes at the age of 2 years. Objectives: To determine whether early aEEG patterns in preterm infants are equally useful in predicting outcomes at early school age. Methods: We recorded aEEG in 41 preterms (gestational age 26.0–32.9 weeks) at a median postnatal age of 9.7 h (IQR 7.0–25.3) and in 43 preterms on median day 8 (IQR 7–9). We assessed aEEG by pattern recognition and calculated the means of the aEEG amplitude centiles. At a median of 7.39 years, i.e., early school age, we assessed their motor, cognitive, and behavioral outcomes. Results: Depressed aEEG patterns were not associated with poorer outcomes. Cyclicity directly after birth was associated with a higher total IQ (mean 104 vs. 97, p = 0.05) and higher scores on visual perception (mean percentile 57.1 vs. 40.1, p = 0.049) and visual memory (mean percentile 34.5 vs. 19.1, p = 0.090). We found some associations between the aEEG amplitude centiles and cognitive outcomes, but none for motor or behavioral outcomes. There was an increased risk of abnormal scores on long-term verbal memory in cases of the lower 5th and 50th aEEG amplitude centiles directly after birth. The odds ratios were 0.65 (95% CI 0.42–0.99, p = 0.040) and 0.71 (95% CI 0.52–0.96, p = 0.025), respectively. Conclusions: In relatively healthy preterm infants the value of aEEG in predicting neuropsychological outcomes at early school age is limited. The presence of cyclicity directly after birth tends to be associated with better cognition.
Natural History of Vertebrobasilar Dolichoectatic and Fusiform Aneurysms: A Systematic Review and Meta-Analysis
Authors: Nasr Deena M. , Flemming Kelly D. , Lanzino Giuseppe , Cloft Harry J. , Kallmes David F. , Murad Mohammad Hassan , Brinjikji Waleed
Published: February 2018

Background and Purpose: Vertebrobasilar non-saccular and dolichoectatic aneurysms (VBDA) are a rare type of aneurysm and are generally associated with poor prognosis. In order to better characterize the natural history of VBDAs, we performed a systematic review and meta-analysis of the literature to determine rates of mortality, growth, rupture, ischemia, and intraparenchymal hemorrhage. Materials and Methods: We searched the literature for longitudinal natural history studies of VBDA patients reporting clinical and imaging outcomes. Studied outcomes included annualized rates of growth, rupture, ischemic stroke, intracerebral hemorrhage (ICH), and mortality. We also studied the association between aneurysm morphology (dolichoectatic versus fusiform) and natural history. Meta-analysis was performed using a random-effects model using summary statistics from included studies. Results: Fifteen studies with 827 patients and 5,093 patient-years were included. The overall annual mortality rate among patients with VBDAs was 13%/year (95% CI 8–19). Patients with fusiform aneurysms had a higher mortality rate than those with dolichoectatic aneurysms, but this did not reach statistical significance (12 vs. 8%, p = 0.11). The overall growth rate was 6%/year (95% CI 4–13). Patients with fusiform aneurysms had higher growth rates than those with dolichoectatic aneurysms (12 vs. 3%, p < 0.0001). The overall rupture rate was 3%/year (95% CI 1–5). Patients with fusiform aneurysms had higher rupture rates than those with dolichoectatic aneurysms (3 vs. 0%, p < 0.0001). The overall rate of ischemic stroke was 6%/year (95% CI 4–9). Patients with dolichoectatic aneurysms had higher ischemic stroke rates than those with fusiform aneurysms, but this did not reach statistical significance (8 vs. 4%, p = 0.13). The overall rate of ICH was 2%/year (95% CI 0–8) with no difference in rates between dolichoectatic and fusiform aneurysms (2 vs. 2%, p = 0.65). Conclusion: In general, the natural history of ­VBDAs is poor. However, dolichoectatic and fusiform ­VBDAs appear to have distinct natural histories with substantially higher growth and rupture associated with fusiform aneurysms. These findings suggest that these aneurysms should be considered separate entities. Further studies on the natural history of vertebrobasilar dolichoectatic and fusiform aneurysms with more complete follow-up are needed to better understand the risk factors for progression of these aneurysms.
Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients
Authors: Kovarova Lucie , Valerianova Anna , Kmentova Tereza , Lachmanova Jana , Hladinova Zuzana , Malik Jan
Published: February 2018

Background/Aims: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association. Our secondary aim was to assess other factors possibly related to cerebral ischemia and CI. Methods: Thirty-nine patients treated by chronic HD were included in this cross-sectional study. All measurements were performed before the initiation of an HD session. The Montreal Cognitive Assessment (MoCA) was administered according to published recommendations. Regional saturation of oxygen (rSO2) of the left frontal lobe was measured using the INVOS 5100C device. Basic medical history and laboratory data were recorded, and handgrip strength was analyzed. We used the unpaired t test to compare the rSO2 and other variables between cognitively normal patients (MoCA score ≥26) and those who displayed CI (MoCA score <26). Multiple linear regression analysis was used to adjust for principal confounders. Results: Cognitively impaired patients had lower brain rSO2 values compared to cognitively normal patients (48 ± 9 vs. 57 ± 10%, p = 0.01). Among other variables, higher red cell distribution width (15.8 ± 1.9 vs. 13.8 ± 1.6%, p = 0.01) and lower hand grip strength (49.2 ± 23.3 vs. 99.3 ± 31.4 lbs, p < 0.001) also displayed a significant association with CI. The relation between rSO2 and MoCA score was significant after adjustment for age and gender (p = 0.007). Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.
Hoxa5 Promotes Adipose Differentiation via Increasing DNA Methylation Level and Inhibiting PKA/HSL Signal Pathway in Mice
Authors: Cao Weina , Xu Yatao , Luo Dan , Saeed Muhammad , Sun Chao
Published: February 2018

Background/Aims: Impaired adipogenesis may be the underlying cause in the development of obesity and type II diabetes. Mechanistically, the family of Homeobox transcription factors is implicated in the regulation of adipocyte fate. Hoxa5 is highly expressed in adipocytes, and its mRNA expression is decreased during differentiation. However, the function of Hoxa5 in adipose tissue has been poorly understood. The aim of this study is to unveil the role of Hoxa5 on adipocyte differentiation and its underlying mechanisms. Methods: Quantitative real-time PCR (qPCR) and western blot were performed to determine Hoxa5 expression in primary adipocytes and in adipose tissues from mice. Lipid accumulation was evaluated by bodipy staining. Dual luciferase assay was applied to explore the transcription factor of Hoxa5 and the transcriptional target gene modulated by Hoxa5. All measurements were performed at least for three times at least. Results: A significant reduction of Hoxa5 expression was observed in adipose tissue of High Fat Diet (HFD) induced obesity mice. We determined Hoxa5 increased adipocytes differentiation and mitochondrial biogenesis in adipocytes in vitro. CEBPβ was determined a transcription factor of Hoxa5 and inhibited methylation level of Hoxa5 by combining on the promoter of Hoxa5. Importantly, we found Fabp4, a known positive regulator of adipocytes differentiation, was transcriptional activation by Hoxa5. In addition, Hoxa5 promotes adipocytes differentiation by inhibiting PKA/HSL pathway. Conclusion: Our study demonstrated the promoting role of Hoxa5 in adipocytes differentiation and therefore bringing a new therapeutic mean to the treatment of obesity and type II diabetes.
Downregulation of SPINK13 Promotes Metastasis by Regulating uPA in Ovarian Cancer Cells
Authors: Cai Shengyun , Zhang Pei , Dong Suhe , Li Li , Cai Jianming , Xu Mingjuan
Published: February 2018

Background/Aims: Ovarian cancer (OC) is the fifth leading cause of cancer-related death in women, and it is difficult to diagnose at an early stage. The purpose of this study was to explore the prognostic biological markers of OC. Methods: Univariate Cox regression analysis was used to identify genes related to OC prognosis from the Cancer Genome Atlas(TCGA) database. Immunohistochemistry was used to analyse the level of SPINK13 in OC and normal tissues. Cell proliferation, apoptosis and invasion were performed using MTT assay, flow cytometric analysis and Transwell assay, respectively. Results: We identified the Kazal-type serine protease inhibitor-13 (SPINK13) gene related to OC prognosis from the Cancer Genome Atlas (TCGA) database by univariate Cox regression analysis. Overexpression of SPINK13 was associated with higher overall survival rate in OC patients. Immunohistochemistry showed that the level of SPINK13 protein was significantly lower in OC tissues than in normal tissues (P < 0.05).In vitro experiments showed that the overexpression of SPINK13 inhibited cellular proliferation and promoted apoptosis. Moreover, SPINK13 inhibited cell migration and epithelial to mesenchymal transition (EMT). SPINK13 was found to inhibit the expression of urokinase-type plasminogen activator (uPA), while recombinant uPA protein could reverse the inhibitory effect of SPINK13 on OC metastasis. Conclusion: These results indicate that SPINK13 functions as a tumour suppressor. The role of SPINK13 in cellular proliferation, apoptosis and migration is uPA dependent, and SPINK13 may be used as a potential biomarker for diagnosis and targeted therapy in OC.
Anxiety After Stroke
Authors: Chun Ho-Yan Yvonne , Whiteley William N. , Dennis Martin S. , Mead Gillian E. , Carson Alan J.
Published: February 2018

Background and Purpose—

Anxiety after stroke is common and disabling. Stroke trialists have treated anxiety as a homogenous condition, and intervention studies have followed suit, neglecting the different treatment approaches for phobic and generalized anxiety. Using diagnostic psychiatric interviews, we aimed to report the frequency of phobic and generalized anxiety, phobic avoidance, predictors of anxiety, and patient outcomes at 3 months poststroke/transient ischemic attack.

Methods—

We followed prospectively a cohort of new diagnosis of stroke/transient ischemic attack at 3 months with a telephone semistructured psychiatric interview, Fear Questionnaire, modified Rankin Scale, EuroQol-5D5L, and Work and Social Adjustment Scale.

Results—

Anxiety disorder was common (any anxiety disorder, 38 of 175 [22%]). Phobic disorder was the predominant anxiety subtype: phobic disorder only, 18 of 175 (10%); phobic and generalized anxiety disorder, 13 of 175 (7%); and generalized anxiety disorder only, 7 of 175 (4%). Participants with anxiety disorder reported higher level of phobic avoidance across all situations on the Fear Questionnaire. Younger age (per decade increase in odds ratio, 0.64; 95% confidence interval, 0.45–0.91) and having previous anxiety/depression (odds ratio, 4.38; 95% confidence interval, 1.94–9.89) were predictors for anxiety poststroke/transient ischemic attack. Participants with anxiety disorder were more dependent (modified Rankin Scale score 3–5, [anxiety] 55% versus [no anxiety] 29%;
P
<0.0005), had poorer quality of life on EQ-5D5L, and restricted participation (Work and Social Adjustment Scale: median, interquartile range, [anxiety] 19.5, 10–27 versus [no anxiety] 0, 0–5;
P
<0.001).

Conclusions—

Anxiety after stroke/transient ischemic attack is predominantly phobic and is associated with poorer patient outcomes. Trials of anxiety intervention in stroke should consider the different treatment approaches needed for phobic and generalized anxiety.
Clinical and Demographic Characteristics Associated With Suboptimal Primary Stroke and Transient Ischemic Attack Prevention
Authors: Turner Grace M. , Calvert Melanie , Feltham Max G. , Ryan Ronan , Finnikin Samuel , Marshall Tom
Published: February 2018

Background and Purpose—

Primary prevention of stroke and transient ischemic attack (TIA) is important to reduce the burden of these conditions; however, prescribing of prevention drugs is suboptimal. We aimed to identify individual clinical and demographic characteristics associated with potential missed opportunities for prevention therapy with lipid-lowering, anticoagulant, or antihypertensive drugs before stroke/TIA.

Methods—

We analyzed anonymized electronic primary care records from a UK primary care database that covers 561 family practices. Patients with first-ever stroke/TIA, ≥18 years, with diagnosis between January 1, 2009, and December 31, 2013, were included. Missed opportunities for prevention were defined as people with clinical indications for lipid-lowering, anticoagulant, or antihypertensive drugs but not prescribed these drugs before their stroke/TIA. Mixed-effect logistic regression models evaluated the relationship between missed opportunities and individual clinical/demographic characteristics.

Results—

The inclusion criteria were met by 29 043 people with stroke/TIA. Patients with coronary heart disease, chronic kidney disease, peripheral arterial disease, or diabetes mellitus were at less risk of a missed opportunity for prescription of lipid-lowering and antihypertensive drugs. However, patients with a 10-year cardiovascular disease risk ≥20% but without these diagnoses had increased risk of having a missed opportunity for prescription of lipid-lowering drugs or antihypertensive drugs. Women were less likely to be prescribed anticoagulants but more likely to be prescribed antihypertensive drugs. The elderly (≥85 years of age) were less likely to be prescribed all 3 prevention drugs, compared with people aged 75 to 79 years.

Conclusions—

Knowing the patient characteristics predictive of missed opportunities for stroke prevention may help primary care identify and appropriately manage these patients. Improving the management of these groups may reduce their risk and potentially prevent large number of future strokes and TIAs in the population.
Continuing the Legacy of Edinburgh
Authors: Bevans Stephen
Published: February 2018

This article discusses the background and content of the Regnum Edinburgh Centenary. The article offers a “bird’s eye view” of the series that contain reflections from a wide variety of perspectives. The article also deals with reflections on the context and content of the series.
Basil of Caesarea’s Authorship of Epistle 361 and His Relationship with the Homoiousians Reconsidered
Authors: Giulea Dragoş Andrei
Published: February 2018

A comparative analysis of Ep. 361 and Eun. 1.19 in terms of language and ideas will offer a renewed confirmation (on internal grounds) of Basil of Caesarea’s authorship of Ep. 361 and a new perspective on Basil’s relationship with the Homoiousians. In addition, the article will also retrace the steps and revisit the purpose of Basil’s argument. Thus we discover in the early Basil an author simultaneously receptive to both Homoiousian and pro-Nicene visions, but leaning towards an improved Homoiousian solution. The article further investigates Basil’s vision of ousia in Ep. 361 and finds that—unlike in his later, mature, period—the early Basil shares with the Homoiousians and Eusebius of Caesarea two doctrinal elements, namely the understanding of ousia as individual substance and an associated theology of “likeness”. He inherits this view from a tradition originating in the third century, which received its official confirmation at the council of Antioch in 268. This vision is also present in the first part of Basil’s Contra Eunomium. Instead of considering Basil as a Homoiousian, one may see him, together with Eusebius and the Homoiousians, as a representative of the Antiochene legacy.
Basil of Ancyra’s Treatise on Faith: Confirming the Authorship
Authors: Morales Xavier
Published: February 2018

In the 2011 issue of Vigiliae Christianae, Mark DelCogliano challenged my attribution of the Homoiousian response to the Dated Creed of summer 359 to Basil of Ancyra. In this article, I confirm Basil’s authorship with new philological and stylistic evidence and compare Basil’s role with that of George of Laodicea, the other main figure of the Homoiousian party, which md considered as the primary author of the document.
Julius Stone, Aggression, and the Future of the International Criminal Court
Authors: Galán Alexis
Published: February 2018

The article is concerned with the crime of aggression, the long and contested history behind its regulation, the final incorporation in the Rome Statute, and the implication of the regulation for the standing of the international criminal court. In order to explain and understand the struggle over aggression, the article recovers the writings of Julius Stone. It is contended that his writings can not only help us in understanding the key elements that have made aggression a highly controversial topic in international criminal law but also in comprehending the underlying features of the current regulation. Drawing on Stone’s account of justice, the article further suggests that, in light of the position in which the court finds itself, it should approach the crime of aggression with modesty and self-restrain.
A Disorder of Identity: Religious Difference ‘without’ ‘Religion’
Authors: van Hoogstraten Marius
Published: February 2018

Responding to Paul Hedges’ paper earlier in this volume, I discuss the consequences of the deconstruction of ‘religion’ for the ‘interreligious.’ First, I bring Paul Hedges’ ‘soft’ deconstruction into conversation with John Thatamanil’s comparative theology ‘after’ religion. While the former argues that religion, while always contextually situated, clearly still has ‘reality’, Thatamanil rather argues that the social reality of those practices and collectivities dubbed ‘religions’ is much more blurry and difficult than what the discourse on religion assumes. Far from a purely academic endeavour, taking seriously the deconstruction of ‘religion’ means taking seriously the violent history that has taken place under its name. Then I argue, drawing on John Caputo’s ‘religion without religion’, that instead of relying on fictions of solid or ‘pure’ foundations, of ‘religions’ as clearly delineated representative systems, interreligious engagement ought to embrace this blurring of boundaries and the inherent instability of their languages. Finally, however, I propose that Caputo as well as Hedges leave uninterrogated the underlying assumption that ‘religion’ precedes ‘religious difference’. Rather than finding some definition of ‘religion’ to understand or define religious difference, it may be necessary to trace how religious difference is employed to understand and define ‘religions’, most significantly how some collectivities and practices come to be defined as ‘other religions’.
Fair and Equitable Treatment: Its Interaction with the Minimum Standard and Its Customary Status
Authors: Dumberry Patrick
Published: February 2018

The book addresses two questions which have been debated by scholars in the last 20 years regarding the fair and equitable treatment (‘fet’) standard found in bits. It examines the interaction between the ‘minimum standard of treatment’ (mst) and the fet standard. It first analyses the fascinating story of how the concept of the mst emerged in the early 20th Century, its subsequent decline from 1960s until the 1990s and its surprising recent ‘resurrection’ in the year 2000. This evolution has had a direct impact on the emergence and subsequent development of the fet standard and explains why States started referring to that standard instead of the mst in their investment treaties. One question addressed in this book, is whether fet is an autonomous standard of protection to be accorded to foreign investors, or is a mere reference to the mst under customary international law. Given the fact that the fet standard is found in the overwhelming majority of bits, another question which arose is whether or not it should now be considered in and of itself as a rule of customary international law.
On the brink of extinction: two new species of Anomaloglossus from French Guiana and amended definitions of Anomaloglossus degranvillei and A. surinamensis (Anura: Aromobatidae)
Authors: FOUQUET ANTOINE , VACHER JEAN-PIERRE , COURTOIS ELODIE A. , VILLETTE BENOIT , REIZINE HUGO , GAUCHER PHILIPPE , JAIRAM RAWIEN , OUBOTER PAUL , KOK PHILIPPE J. R.
Published: February 2018

A large portion of the amphibian species occurring in Amazonia remains undescribed. A recent study on species delineation in Anomaloglossus, a genus endemic to the Guiana Shield, demonstrated the existence of two undescribed species previously identified as A. degranvillei, which we describe herein. In addition to divergence at the molecular level, these two new taxa are also distinguished by subtle morphological characters and substantial differences in the advertisement calls (note length, dominant frequency, note structure). One species occurs in the hilly lowlands of north-eastern French Guiana and is mainly distinguished from its closest relatives by a small body size (15.9–18.8 mm in males) and by vocalisations characterized by the emission of short notes of 0.09 s on average. The other species is only known from the Itoupé Massif in southern French Guiana and is mainly distinguished from its closest relatives by a moderate body size (19.4–20.4 mm in males) and by vocalisations characterized by the emission of long notes of 0.23 s on average. We also provide amended definitions for two previously described species in the A. degranvillei species group: A. degranvillei, which is endemic to a few massifs in central French Guiana, and A. surinamensis, which is distributed throughout Suriname and French Guiana. The new species described here and A. degranvillei have very narrow ranges within French Guiana and seem to have rapidly declined during the last decade. Therefore, we suggest A. degranvillei and A. dewynteri to be considered as “Critically Endangered” and A. blanci as “Vulnerable” according to the IUCN standards.
Annotated checklist of freshwater fishes from Brunei Darussalam, Borneo
Authors: SULAIMAN ZOHRAH , HUI TAN HEOK , LIM KELVIN KOK PENG
Published: February 2018

The freshwater fish diversity of Brunei Darussalam is reviewed. At present, a total of 104 species of freshwater fishes from 59 genera, 24 families and 10 orders is recorded. Eight species including one introduced species and two from brackish waters present new records for Brunei. The family Cyprinidae has the highest diversity with 40 species. Forty-six species are believed to be endemic to Borneo including six species known only from Brunei Darussalam namely Barbodes xouthos, Rasbora tubbi, Gastromyzon cranbrookii, Gastromyzon venustus, Neogastromyzon brunei and Ompok platyrhynchus and three are exotics.
Description of the larva of Adicella cremisa Malicky 1972 and a larval key to Central European species of Adicella McLachlan 1877 (Trichoptera: Leptoceridae)
Authors: GRAF WOLFRAM , WARINGER JOHANN , DÜRREGGER ALEXANDER , VITECEK SIMON
Published: February 2018

This contribution describes the previously unknown larva of Adicella cremisa Malicky 1972. Information on the morphology of the 5th larval instar is given and the important diagnostic features are highlighted on micrographs. Within the genus Adicella the hitherto known larvae differ in color patterns of the head capsule, the morphology of the posterior process of abdominal segment I, and in setation patterns on the metanotum, metasternum, abdominal segment IX, and anal prolegs. With respect to zoogeography, A. filicornis and A. reducta are widespread throughout Europe whereas A. cremisa is restricted to European Ecoregions 3 (Italian Mainland), 5 (Dinaric Western Balkan: Slovenia, Croatia), 9 (Central Highlands: Austria) and 11 (Hungarian Plains; Vienna). Based on mandible morphology, A. cremisa is likely a collector-gatherer and shredder.
Satanoperca curupira, a new cichlid species from the rio Madeira basin in Brazil (Teleostei: Cichlidae)
Authors: OTA RENATA R. , KULLANDER SVEN O. , DEPRÁ GABRIEL C. , GRAÇA WEFERSON J. DA , PAVANELLI CARLA S.
Published: February 2018

Satanoperca curupira, new species, is described from the rio Madeira basin in the State of Rondônia, Brazil. It is distinguished from all congeners by the following combination of characters: 3–7 dark-brown oblique stripes on the lachrymal (vs. 2 well-defined dark-brown stripes, or dark-brown stripes absent) and an irregular pattern of dark-brown stripes on cheek and opercular series (vs. cheek without dark-brown markings or with light-beige rounded spots). According to meristic and color pattern characters, the new species is considered a member of the S. jurupari species group, and is syntopic with S. jurupari, which is widespread in the Amazon basin. The restricted geographical range of the new species is congruent to that observed for some other Satanoperca species.
Evaluating Global Land Surface Models in CMIP5: Analysis of Ecosystem Water- and Light-Use Efficiencies and Rainfall Partitioning
Authors: Li Longhui , Wang Yingping , Arora Vivek K. , Eamus Derek , Shi Hao , Li Jing , Cheng Lei , Cleverly James , Hajima T. , Ji Duoying , Jones C. , Kawamiya M. , Li Weiping , Tjiputra J. , Wiltshire A. , Zhang Lu , Yu Qiang
Published: February 2018

Water and carbon fluxes simulated by 12 Earth system models (ESMs) that participated in phase 5 of the Coupled Model Intercomparison Project (CMIP5) over several recent decades were evaluated using three functional constraints that are derived from both model simulations, or four global datasets, and 736 site-year measurements. Three functional constraints are ecosystem water-use efficiency (WUE), light-use efficiency (LUE), and the partitioning of precipitation P into evapotranspiration (ET) and runoff based on the Budyko framework. Although values of these three constraints varied significantly with time scale and should be quite conservative if being averaged over multiple decades, the results showed that both WUE and LUE simulated by the ensemble mean of 12 ESMs were generally lower than the site measurements. Simulations by the ESMs were generally consistent with the broad pattern of energy-controlled ET under wet conditions and soil water-controlled ET under dry conditions, as described by the Budyko framework. However, the value of the parameter in the Budyko framework ω, obtained from fitting the Budyko curve to the ensemble model simulation (1.74), was larger than the best-fit value of ω to the observed data (1.28). Globally, the ensemble mean of multiple models, although performing better than any individual model simulations, still underestimated the observed WUE and LUE, and overestimated the ratio of ET to P, as a result of overestimation in ET and underestimation in gross primary production (GPP). The results suggest that future model development should focus on improving the algorithms of the partitioning of precipitation into ecosystem ET and runoff, and the coupling of water and carbon cycles for different land-use types.
The Impact of Psychosocial Factors on Health and Retention Outcomes for People Living With HIV: Implications for Rehabilitation Counselors and Educators
Authors: Chiu Yung-Chen Jen , Boomer K. B. , Conyers Liza M.
Published: February 2018

Despite medical advancements that have significantly improved the health outcomes of people living with HIV (PLWH), many do not achieve optimal health outcomes due to psychosocial barriers. This 5-year retrospective longitudinal study draws upon the International Classification of Functioning, Disability, and Health (ICF) framework to conceptualize the relationships between personal and environmental factors and health and retention outcomes among a sample of 704 PLWH in Pennsylvania. A generalized estimated equations (GEE) model was used to model retention in care outcomes (at least one medical visit every 6 months) and a general linear mixed (GLM) model was used to analyze immune system health outcomes (CD4%). This exploratory study reveals that gender, age, race, use of antiretroviral (ARV) medications, use of case management service, mental health diagnosis, and alcohol use were significantly associated with retention in care, whereas race, ethnicity, gender, mental health treatment, use of ARV medications, use of case management services, and retention in care status were significantly associated with the immune system health outcome of CD4%. The results suggest a need for rehabilitation interventions to address key psychosocial issues, as rehabilitation counselors have a unique skill set to address the medical case management needs of individuals with HIV. Implications for rehabilitation counselors and educators are discussed.
Unrepaired Complete Tracheal Rings: Natural History and Management Considerations
Authors: Wilcox Lyndy J. , Hart Catherine K. , de Alarcon Alessandro , Schweiger Claudia , Peddireddy Nithin S. , Tabangin Meredith , Rutter Michael J.
Published: February 2018

Objectives

To document the natural growth pattern of unrepaired complete tracheal rings (UCTRs) and describe the patient population managed conservatively.

Study Design

Case series with chart review.

Setting

Tertiary pediatric academic center.

Subjects/Methods

Medical records of patients with confirmed complete tracheal rings on bronchoscopy from 1993 to 2017 were reviewed. Patients aged 0 to 18 who had documented tracheal sizing over time and did not require surgical intervention were included. Exclusion criteria included tracheal stenosis not caused by complete tracheal rings. Comorbidities and airway characteristics were documented in addition to endoscopic findings. These were compared with children requiring surgical repair.

Results

In total, 149 patients with complete tracheal rings were identified. Twenty‐five had UCTRs for an overall 16.8% rate of conservative management. Nineteen patients met inclusion criteria and underwent a total of 90 microlaryngoscopy and bronchoscopies (MLBs) with sizing. The growth of the UCTRs over time, based on MLB sizing, was chronicled. The median airway growth noted was 0.38 mm/y. A moderately strong positive correlation was seen between age and airway size (rs = 0.72, P <. 0001). Children with UCTRs were less likely to have long‐segment involvement than those who required repair (92%, P =. 024).

Conclusions

A select group of children with complete tracheal rings can be managed expectantly without surgical intervention. Conservative management may be less successful in children with long‐segment complete tracheal rings. Airway growth does occur in this population and can be monitored over time. Having a standardized method for sizing UCTRs allows for more effective communication between providers and assurance of continued growth of the airway while following these patients.
Patient Choice of Nonsurgical Treatment Contributes to Disparities in Head and Neck Squamous Cell Carcinoma
Authors: Parhar Harman S. , Anderson Donald W. , Janjua Arif S. , Durham J. Scott , Prisman Eitan
Published: February 2018

Objectives

There are well‐established outcome disparities among different demographic groups with head and neck squamous cell carcinoma (HNSCC). We aimed to investigate the potential contribution of patient choice of nonsurgical treatment to these disparities by estimating the rate of this phenomenon, identifying its predictors, and estimating the effect on cancer‐specific survival.

Study Design

Retrospective nationwide analysis.

Settings

Surveillance, Epidemiology, and End Results Database (2004‐2014).

Subjects and Methods

Patients with HNSCC, who were recommended for primary surgery, were included. Multivariable logistic regression was used to identify demographic and clinical factors associated with patient choice of nonsurgical treatment, and Kaplan Meier/Cox regression was used to analyze survival.

Results

Of 114,506 patients with HNSCC, 58,816 (51.4%) were recommended for primary surgery, and of those, 1550 (2.7%) chose nonsurgical treatment. Those who chose nonsurgical treatment were more likely to be older (67.1 ± 12.6 vs 63.6 ± 13.1, P <. 01), were of Black (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.28‐1.74) or Asian (OR = 1.79; 95% CI, 1.46‐2.20) ethnicity, were unmarried (OR married, 0.50; 95% CI, 0.44‐0.58), had an advanced tumor, and had a hypopharyngeal or laryngeal primary. Choice of nonsurgical treatment imparted a 2.16‐fold (95% CI, 2.02‐2.30) increased risk of cancer‐specific death.

Conclusion

Of the patients, 2.7% chose nonsurgical treatment despite a provider recommendation that impairs survival. Choice of nonsurgical treatment is associated with older age, having Black or Asian ethnicity, being unmarried, having an advanced stage tumor, and having a primary site in the hypopharynx or larynx. Knowledge of these disparities may help providers counsel patients and help patients make informed decisions.
Clinicopathologic Characteristics and Survival Outcomes in Floor of Mouth Squamous Cell Carcinoma: A Population‐Based Study
Authors: Saggi Satvir , Badran Karam W. , Han Albert Y. , Kuan Edward C. , St. John Maie A.
Published: February 2018

Objective

To describe the determinants of survival for patients with floor of mouth (FOM) squamous cell carcinoma (SCC) from 1973 to 2013 with the SEER database (Surveillance, Epidemiology, and End Results).

Study Design and Setting

Retrospective cohort study with a national database.

Subjects and Methods

The SEER registry was utilized to calculate survival trends for patients with FOM SCC between 1973 and 2013. Patient data were analyzed with respect to age, sex, race, primary site, stage at presentation, tumor size, grade, and treatment modalities (surgery and radiotherapy). Overall survival (OS) and disease‐specific survival (DSS) were calculated.

Results

A total of 14,010 FOM SCC cases were identified. The cohort was 69.5% male, and the median age at diagnosis was 62 years. Forty‐six percent of cases were treated with surgery, while 14% received radiotherapy. Kaplan‐Meier analysis demonstrated OS and DSS of 39% and 59% at 5 years, respectively. Multivariate analysis showed that age, grade, stage, size, and surgery were determinants for OS and DSS (all P <. 05). For early‐ and advanced‐stage cancers, age, grade, size, and surgery predicted OS and DSS, while radiotherapy was a predictor of OS and DSS in advanced‐stage tumors only (all P <. 05).

Conclusion

To our knowledge, this study is the largest to date investigating prognostic factors for survival of patients diagnosed with FOM SCC. Determinants of survival include age, grade, stage, size, and surgery. Surgery appears to play a critical role in the management of these tumors.