bluuebunny/crossref_metadata_2025 huggingface dataset:
Nurses' Experience of Occupational Alienation in the Clinical Setting: A Content Analysis
Authors: Salehian Maryam , Goli Hamideh , Yazdimoghaddam Hamideh
Published: August 2024

Background:

Job alienation of nurses leads to adverse consequences such as occupational dysfunction and low quality of health-care services provided by these individuals to patients. This study aimed to explain nurses' experience of occupational alienation in the clinical setting.

Materials and Methods:

This qualitative study was conducted using the content analysis method. Data were collected via 18 in-depth and semistructured interviews from nurses working in the hospitals in Sabzevar, Iran. The participants were selected via purposive sampling and continued till data saturation. The obtained data were simultaneously analyzed using conventional qualitative content analysis.

Results:

The qualitative analysis of data content led to the extraction of the themes that reflected the nurses' experience of occupational alienation in the clinical environment. After the transcription of each interview, the obtained data were broken down into codes in the form of sentences and paragraphs related to the main concept. The codes were reviewed several times and the relevant semantic unit codes were written down and classified based on conceptual and semantic similarity. Qualitative data analysis led to the emergence of 260 initial codes, 120 subcategories, 30 main categories, and 6 themes. Finally, the main theme of the “nursing gradual separation from caring and clinical aspect” was extracted.

Conclusions:

According to the results, occupational alienation reduces the quality of patient care, weakens nurses, and reduces the continuity of their effective and active presence in the provision of care services and clinical decision-making. Therefore, managerial and organizational interventions are required to address this issue.
Is Web-Based Program Effective on Self-Care Behaviors and Glycated Hemoglobin in Patients with Type 2 Diabetes: A Randomized Controlled Trial
Authors: Eghtedari Maryam , Goodarzi-Khoigani Masoomeh , Shahshahani Maryam Sadat , Javadzade Homamodin , Abazari Parvaneh
Published: August 2024

Background:

Diabetes Self-Management Education and Support (DSMES) as a framework focuses on seven self-care behaviors. Moreover, technology-assisted self-care education is increasingly suggested for patients with Type 2 Diabetes Mellitus (T2DM). Therefore, we examined the effect of a web-based program on self-care behaviors and glycated hemoglobin values in patients with diabetes mellitus.

Materials and Methods:

This randomized controlled clinical trial was conducted at Alzahra Hospital in Isfahan, Iran, between April and November 2020 and included 70 patients with T2DM. Data were collected using a questionnaire that included a demographic information section and a diabetes self-management section with 21 questions on a Likert scale. Fasting blood samples (2.50 ml) were collected before and after the interventions to measure HbA1c levels. The study intervention involved a web-based program that included multimedia educational content (such as videos, lectures, educational motion graphics, text files, posters, and podcasts) presented in seven sections based on DSMES over a 21-day period with monitoring by an instructor.

Results:

The mean scores for healthy eating (F = 3.48, p = 0.034) and medication adherence (F = 6.70, p < 0.001) significantly increased in the interventional group, while the mean scores for being active, monitoring, reducing risks, problem-solving, and healthy coping did not significantly change. Additionally, the mean differences in HbA1c values significantly improved in the interventional group compared to the control (F = 5,1, p = 0.026).

Conclusions:

A web-based program in accordance with DSMES improved HbA1c levels and increased scores for healthy eating and medication adherence in patients with T2DM. However, further research with larger sample sizes and qualitative interviews is needed.
To assess the effect of selected locally available beverages on salivary pH, flow rate, and oral clearance rate among adults
Authors: Virk Jasleen , Malhan Sunil , Sandhu Gursandeep Kaur , Sood Himanshu , Ishita  , Prabhakar Danish
Published: August 2024

Aim:

The aim of this study is to assess the effect of selected locally available beverages on salivary pH, flow rate, and oral clearance rate among adults.

Materials and Methods:

A quantitative diagnostic method for dental caries would improve oral health, which directly affects the quality of life. The pH scale measures how acidic or basic a solution is, with 7 being neutral. When the pH of plaque drops below normal, or <5.5, the acidity starts to dissolve minerals and destroy the tooth’s enamel. This clinical trial will be conducted on 40 subjects. Test beverages will be Red Bull, mixed fruit juice, tea, and sweetened milk. Unstimulated salivary samples will be collected for each study subject at least 1 h after their breakfast. After the collection of baseline salivary samples, the subjects will be given one beverage to drink, and then stimulated saliva samples will be collected at fixed time intervals. A digital pH meter will be used to measure the pH at every step.

Statistical Analysis:

This will be carried out using SPSS version 17, one-way ANOVA, and post hoc Tukey’s test will be applied in the statistical tests.

Results:

The maximum drop in pH was seen in the case of carbonated beverage (Red Bull), the oral clearance for all the liquid food items was achieved at 14 minutes.

Conclusions:

Liquids had a considerable cariogenic and erosive potential despite their quick clearance from the mouth cavity. it is always recommended to limit beverage consumption to maintain good dental health.
Comparative evaluation of the osteogenic capacity of second-generation platelet concentrates on dental pulp stem cells – An ex vivo study
Authors: Panda Bandana , Patri Gaurav , Jena Debkant , Behera Ranjan Rashmi , Agarwal Vanshika , Gupta Aditi
Published: August 2024

Introduction:

Clinical evidence of platelet-rich fibrin (PRF) benefits on bone repair is still emerging, prompting researchers to experiment with different PRF formulations as osteoconductive scaffolds.

Aims:

This study compared the osteoconductive effects of injectable PRF (i-PRF) and leukocyte-rich PRF (L-PRF) on the differentiation of dental pulp stem cells (DPSCs) into osteoblasts.

Materials and Methods:

Blood samples were collected from the volunteers to prepare L-PRF and i-PRF conditioned media (CM) by centrifugation. DPSCs were isolated from impacted third molars and cultured. Proliferation of DPSCs in response to L-PRF and i-PRF was assessed by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Osteoinductive potential was evaluated through alkaline phosphatase (ALP) activity, alizarin red S (ARS) staining, growth factor levels (vascular endothelial growth factor [VEGF], transforming growth factor [TGF-beta]), and cytokine expression (interleukin 6 [IL-6], IL-8) after 7 days.

Results:

MTT assay results showed that both L-PRF and i-PRF increased DPSC proliferation relative to the control group. After 7 days in L-PRF and i-PRF CM, DPSCs exhibited increased ALP activity, higher red-colored calcium deposits with ARS staining, and elevated levels of VEGF and TGF-beta. In addition, higher concentrations of inflammatory cytokines IL-6 and IL-8 were observed in both L-PRF and i-PRF compared to the control.

Conclusions:

Using both L-PRF and i-PRF as scaffolds can enhance the osteoinductive ability of stem cells, offering a potential strategy for regenerative therapies.
Producing new semi-orthogonal decompositions in arithmetic geometry
Authors: Bondarko Mikhail Vladimirovich
Published: August 2024

This paper is devoted to constructing new admissible subcategories and semi-orthogonal decompositions of triangulated categories out of old ones. For two triangulated subcategories $\mathcal{T}$ and $\mathcal{T}'$ of some category $\mathcal{D}$ and a semi-orthogonal decomposition $(\mathcal{A},\mathcal{B})$ of $\mathcal{T}$ we look either for a decomposition $(\mathcal{A}',\mathcal{B}')$ of $\mathcal{T}'$ such that there are no nonzero $\mathcal{D}$-morphisms from $\mathcal{A}$ into $mathcal{A}'$ and from $\mathcal{B}$ into $\mathcal{B}'$, or for a decomposition $(\mathcal{A}_{\mathcal{D}},\mathcal{B}_{\mathcal{D}})$ of $\mathcal{D}$ such that $\mathcal{A}_{\mathcal{D}}\cap \mathcal{T}=\mathcal{A}$ and $mathcal{B}_{\mathcal{D}}\cap \mathcal{T}=\mathcal{B}$. We prove some general existence statements (that also extend to semi-orthogonal decompositions of arbitrary length) and apply them to various derived categories of coherent sheaves over a scheme $X$ that is proper over the spectrum of a Noetherian ring $R$. This produces a one-to-one correspondence between semi-orthogonal decompositions of $D_{\mathrm{perf}}(X)$ and $D^{\mathrm{b}}(\operatorname{coh}(X))$; the latter extend to $D^-(\operatorname{coh}(X))$, $D^+_{\mathrm{coh}}(\operatorname{Qcoh}(X))$, $D_{\mathrm{coh}}(\operatorname{Qcoh}(X))$ and $D(\operatorname{Qcoh}(X))$ under very mild assumptions. In particular, we obtain a broad generalization of a theorem of Karmazyn, Kuznetsov and Shinder. These applications rely on some recent results of Neeman that express $D^{\mathrm{b}}(\operatorname{coh}(X))$ and $D^-(\operatorname{coh}(X))$ in terms of $D_{\mathrm{perf}}(X)$. We also prove a rather similar new theorem that relates $D^+_{\mathrm{coh}}(\operatorname{Qcoh}(X))$ and $D_{\mathrm{coh}}(\operatorname{Qcoh}(X))$ (these} are certain modifications of the bounded below and the unbounded derived category of coherent sheaves on $X$ to homological functors $D_{\mathrm{perf}}(X)^{\mathrm{op}}\to R-\mathrm{mod}$. Moreover, we discuss an application of this theorem to the construction of certain adjoint functors. Bibliography: 30 titles.
Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors
Authors: Li De-Gang , Jiang Jia-Peng , Chen Fan-Ye , Wu Wei , Fu Jun , Wang Gong-He , Li Yu-Bo
Published: August 2024

BACKGROUND

Gastrointestinal stromal tumors (GISTs) are typical gastrointestinal tract neoplasms. Imatinib is the first-line therapy for GIST patients. Drug resistance limits the long-term effectiveness of imatinib. The regulatory effect of insulin-like growth factor 2 (IGF2) has been confirmed in various cancers and is related to resistance to chemotherapy and a worse prognosis.

AIM

To further investigate the mechanism of IGF2 specific to GISTs.

METHODS

IGF2 was screened and analyzed using Gene Expression Omnibus (GEO: GSE225819) data. After IGF2 knockdown or overexpression by transfection, the phenotypes (proliferation, migration, invasion, apoptosis) of GIST cells were characterized by cell counting kit 8, Transwell, and flow cytometry assays. We used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition (EMT)-associated proteins. We injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of GIST.

RESULTS

Data from the GEO indicated that IGF2 expression is high in GISTs, associated with liver metastasis, and closely related to drug resistance. GIST cells with high expression of IGF2 had increased proliferation and migration, invasiveness and EMT. Knockdown of IGF2 significantly inhibited those activities. In addition, OE-IGF2 promoted GIST metastasis in vivo in nude mice. IGF2 activated IGF1R signaling in GIST cells, and IGF2/IGF1R-mediated glycolysis was required for GIST with liver metastasis. GIST cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib resistance. Moreover, 2-deoxy-D-glucose (a glycolysis inhibitor) treatment reversed IGF2 overexpression-mediated imatinib resistance in GISTs.

CONCLUSION

IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.
High-altitude speleotherapy in the treatment of bronchial asthma
Authors: Ivanova Olga N. , Ivanova I. S.
Published: August 2024

The present study concerns clinical effects of speleotherapy in bronchial asthma. The aim of our work was to study the efficiency of speleotherapy in a group of patients with bronchial asthma. We observed a group of 51 patients with bronchial asthma (BA) aged 18 to 50 years, who received a course of treatment at the private center “Solevik” (Yakutsk City), carried out at the Department of Allergology and Immunology. All the examined patients were diagnosed with atopic bronchial asthma, of moderate severity. Basic therapy in all cases included Symbicort and Seretide treatment. The patients were managed and monitored before and after the course of treatment by a therapist, pulmonologist and allergologist-immunologist at the outpatient center. Laboratory parameters included general blood tests and the levels of total serum IgE. Examination of patients after a course of speleotherapy revealed disappearance and reduction of asthma attacks (up to 1 attack per month) in 80% of the examined. General blood testing before and after speleotherapy showed decreased levels of blood eosinophils after the course of treatment. I.e., the average initial level of blood eosinophils before treatment was 12±0.4%, being decreased after the course of speleotherapy to 5.5±0.2%. Measurements of total IgE before and after speleotherapy revealed the following results: in patients before therapy, the average level of this index was 500±0.8 units/mL. After a course of speleotherapy, this parameter decreased to 80±0.3 units/ mL.
Speleotherapy shows a positive effect on the clinical course of the patients with bronchial asthma and significantly increases the efficiency of treatment.
Isolation of donor gamma globulin obtained from multiparous women and its effects upon expression of HLA-G and HLA-DR molecules on lymphocytes from mothers of children with septal congenital heart defects
Authors: Shabaldin A. V. , Sinitskaya Anna Viktorovna , Shmulevich S. A. , Grishacheva E. O. , Shabaldina E. V. , Deeva N. S.
Published: August 2024

A common pathogenetic mechanism of reproductive losses and congenital heart disease (CHD) is associated with immune inflammation in the “mother-embryo” system which affects differentiation and proliferation of cardiovascular progenitor cells. It is hypothesized that this link may be blocked by regulatory auto- and alloimmune antibodies to HLA-G and HLA-DR molecules. Moreover, these antibodies may be present at sufficient amounts in donor immunoglobulins, especially those obtained from the blood of multiparous women. Based on this suggestion, the aim of our study was to obtain enriched gamma globulin fraction from the blood of multiparous women and evaluate its functional effects towards HLA-DR and HLA-G molecules. Isolation of the gammaglobulin fraction (GGF) from the blood plasma of multiparous women was performed using affinity chromatography in several sessions. Purity grade of the resulting protein was analyzed by immunoelectrophoresis, electrophoretic separation of the protein fraction of blood serum and electrophoresis in 4.12% polyacrylamide gel with the addition of SDS (PAGE electrophoresis). PAAG electrophoresis showed that this GGF did not differ from commercial therapeutic intravenous immunoglobulin (IVIG). Assessment of the functional activity of GGF upon HLA-DR and HLA-G molecules was performed in the main group of women and their children with congenital heart disease (n = 38), and control group of women who gave birth to conditionally healthy children (n = 21). To determine the specificity of GGF with respect to HLA-G, HLA-DR molecules, as well as to compare its effect with autologous and allogeneic sera and IVIG, we developed an immunological testing protocol using flow cytometry. The protocol was arranged on the basis of the methodology of “cross-match” approach and Russian patent “Method for determining antibodies to HLA-G”. It was found that the blocking activity of female serum towards autologous (intrinsic) and allogeneic (embryo/fetus/child) HLA-G and HLA-DR molecules may determine the protective effect on development of congenital heart defects in the next generation. Donor human immunoglobulin showed a similar blocking effects to these molecules, possibly due to the presence of alloimmune antibodies to HLA classes I and II. The gammaglobulin fraction obtained from the donor blood of multiparous women has a more pronounced blocking effect on the HLA-G and HLA-DR expression. Hence, this immunobiological preparation can be considered a prototype of therapeutic and prophylactic agent blocking the genesis of congenital heart defects.
Role of opioid receptors in phagocytosis regulation and production of Th1/Th2 cytokines under acute cold stress in non-immune mice
Authors: Gein Sergey V. , Sharavieva I. L.
Published: August 2024

Endogenous opioid system plays an important role in the regulation of body functions under stress, providing stress-protective, analgesic and immunoregulatory effects. The aim of this work was to assess the effect of acute cold stress on the in vivo production of adaptive immunity cytokines IL-2, IL-4, IFNγ, phagocytosis, and production of reactive oxygen species in non-immunized mice with induced blockage of opioid receptors. The object of the study were male white mice subjected to acute cold stress at -20 °C for 10 or 60 minutes. To block opioid receptors, naloxone hydrochloride was used, which was administered subcutaneously at a dose of 0.2 mg/kg 20 min before inducing the stress. After the cold exposure, spleen and peritoneal lavage were obtained from the animals. The cytokine concentrations were determined using ELISA technique. The absorption activity of CD11+ cells of the peritoneal cavity was assessed using FITC-stained St.cohnii with a flow cytometer; the production of reactive oxygen species was assessed using the reaction of luminol-dependent chemiluminescence.
It was found that the both cold stress regimens caused naloxone-independent inhibition of spontaneous IFNγ production. In stimulated cultures, an inhibitory effect on IFNγ secretion was registered in animals subjected to stress for only 60 min, being also independent on the opioid receptor blockade. IL-2 production decreased in stimulated cultures against the background of 60 min stress naloxone independently. Both variants of cold stress had no effect on IL-4 production. Stress for 60 min inhibited absorption activity of CD11+ cells from the peritoneal lavage and activated production of oxygen radicals, being, however, canceled by naloxone administration. Hence, acute cold stress led to naloxone-independent inhibition of Th1 cytokine production by splenocytes, naloxone-dependent inhibition of phagocytosis and activation of the microbicidal potential of peritoneal cavity cells.
Immunotherapy for children with malignant brain tumors
Authors: Dolgopolov I. S. , Rykov M. Yu.
Published: August 2024

The incidence of high-grade malignant gliomas (MG) ranges from 35 to 46% of all central nervous system tumors. Despite combined therapy including surgery, radiation treatment and chemotherapy, overall five-year survival does not exceed 10%. The advent of novel immunotherapeutic strategies has promoted a renewed hopes for the treatment of MG. The aim of the present study was to improve the survival rates of glioma patients.
Our study included 5 pediatric patients at the median age of 7.6 years (2-16). Three pts had anaplastic astrocytoma (AA) (1st relapse, 1 pt; 2nd relapse, in 2 pts), One patient was diagnosed with glioblastoma multiforme (GBM) (3rd recurrence), and 1 child had diffuse brainstem glioma (BSG). The median time to the first relapse was 12 months (4 to 16), the second relapse occurred at a median of 5 months (1 to 8). The protocol of immunotherapy included combined administration of autologous dendritic cell-based vaccine (DV) and repeated intrathecal/intraventricular injections of donor allogeneic immunocompetent cells (alloIC) for at least 2 years.
Two of 3 pts with AA experienced a progression-free interval of 67 and 71 months. One patient with 3rd GBM relapse is alive without any treatment for 13.3 years after starting the immunotherapy. The median time of follow-up was 67 months, with the 2-year overall survival rate of 58%. Two pts died from the disease progression within 6 and 7 months from the beginning of immunotherapy. Over the period of treatment, the patients received a median of 20 alloIC injections (8 to 60), and 18 DV administrations (8 to 44). No serious side-effects were observed.
Immunotherapy could be an promising option for treating patients with high-grade malignant gliomas refractory to conventional therapy and, therefore, deserves further investigations.
Complexity results for modal logic with recursion via translations and tableaux
Authors: Aceto Luca , Achilleos Antonis , Anastasiadi Elli , Francalanza Adrian , Ingólfsdóttir Anna
Published: August 2024

This paper studies the complexity of classical modal logics and of their
extension with fixed-point operators, using translations to transfer results
across logics. In particular, we show several complexity results for
multi-agent logics via translations to and from the $\mu$-calculus and modal
logic, which allow us to transfer known upper and lower bounds. We also use
these translations to introduce terminating and non-terminating tableau systems
for the logics we study, based on Kozen's tableau for the $\mu$-calculus and
the one of Fitting and Massacci for modal logic. Finally, we describe these
tableaux with $\mu$-calculus formulas, thus reducing the satisfiability of each
of these logics to the satisfiability of the $\mu$-calculus, resulting in a
general 2EXP upper bound for satisfiability testing.
L’intelligence artificielle au service de la créativité théâtrale
Authors:   University of Arts, Târgu-Mureș, Abou Soughaire Tarik
Published: August 2024

The whole world is currently experiencing a truly unprecedented technological revolution. In this context, there are several digital phenomena that we consider today and among which comes to mind what we call artificial intelligence (AI) having, in one way or another, effects, whether positive or negative, on our journeys, whether personal or professional. The idea of this article is to provoke better reflections, but also an informed understanding of this field of computing whose use has become common in the media despite its definition which remains more or less opaque until the present – and to demonstrate to what extent so-called artificial creativity could be at the service of theatrical creativity. The choice of the title is not by chance, but rather intentional insofar as we aim, above all, to trace the first aspirations of this field, which represents one of the new digital technologies, while arriving, subsequently, to articulate its development, its advantages, but also its disadvantages in relation to theater and theatricality. In this sense, it is necessary to specify the attempts and efforts that scientists have made, even the challenges that they have already supported in order to improve the capabilities of this field so that it evolves and becomes today one of the technological, ideal and creative tools playing an important and effective role not only within the performing arts, but also within all other social and human disciplines.
Accelerating Nature-Based Solutions in Brazilian Cities
Authors: Horn Lara , Tornello Vitor Tramontin , Arioli Magdala Satt , Corrêa Fernando , Azeredo Laura
Published: August 2024

Lições aprendidas na estruturação de projetos em estágio de ideação
Probable Play Behavior in a Surgeonfish (Naso vlamingii )
Authors: Tribelhorn Gunnar Wyn
Published: August 2024

I report an observation of possible play behavior in an individual captive Vlaming's unicornfish (Naso vlamingii). The fish was documented performing locomotory interactions with the filtered stream of water from the return nozzle in its aquarium. Such behaviors conform to existing definitions of play behavior. Animal play is traditionally imagined to be restricted to mammals and birds, with research on this type of behavior remaining scarce within other animals. This finding thus expands upon the ubiquity of play in understudied vertebrate taxa.
Prematuridade tardia: uma revisão sistemática
Authors: Leite Cláudia Roldão , Oliveira Laura Reis de , Beirigo Thayná Pereira
Published: August 2024

A prematuridade tardia refere-se aos nascimentos ocorridos entre 34 e 36 semanas de gestação, representando um desafio significativo para a saúde pública devido às complicações neonatais e ao impacto a longo prazo no desenvolvimento infantil. Este estudo realiza uma revisão sistemática da literatura sobre prematuridade tardia, focando na prevalência, fatores de risco, complicações associadas, intervenções e prognóstico. Foram utilizados artigos científicos brasileiros indexados nas bases de dados PubMed, SciELO e LILACS. Os resultados indicam que a prematuridade tardia é prevalente e associada a fatores maternos, obstétricos e socioeconômicos. Complicações respiratórias, metabólicas e neurológicas são comuns nesse grupo. Intervenções perinatais específicas e cuidados neonatais intensivos são cruciais para melhorar os desfechos. Conclui-se que estratégias de prevenção e manejo adequado são essenciais para reduzir os riscos associados à prematuridade tardia.
Fatores de risco associados aos desfechos da meningite bacteriana pediátrica: uma revisão sistemática
Authors: Elvas Renata Guerra , Paiva Júnior Walterley de Souza , Santana Fabiana Franco Santos de , Dantas Daniela Alves , Pinto Brunna Lopes
Published: August 2024

A meningite bacteriana pediátrica é uma condição médica grave associada a altas taxas de mortalidade e morbidade. Este estudo visa revisar sistematicamente a literatura para identificar os fatores de risco associados aos desfechos dessa doença em crianças. A revisão foi conduzida em diversas bases de dados eletrônicas, incluindo SciELO, LILACS e PubMed, com foco em estudos brasileiros. Os resultados indicam que fatores como idade, estado imunológico, acesso aos cuidados de saúde e características socioeconômicas influenciam significativamente os desfechos da meningite bacteriana em crianças. Conclui-se que a identificação precoce e a gestão adequada desses fatores de risco são cruciais para melhorar os resultados clínicos.
Brinquedo terapêutico no preparo de crianças para procedimentos invasivos: revisão sistemática
Authors: Cad Rafaela Santa Cruz , Oliveira Mariana Borges de , Volpato Giovana Santos
Published: August 2024

O uso de brinquedos terapêuticos no preparo de crianças para procedimentos invasivos tem sido amplamente estudado como uma estratégia para reduzir o estresse e a ansiedade. Esta revisão sistemática visa compilar e analisar as evidências disponíveis sobre a eficácia dessa intervenção. Foram incluídos estudos de bases de dados como PubMed, SciELO e LILACS, publicados entre 2010 e 2023. A maioria dos estudos indicou uma redução significativa nos níveis de ansiedade e melhora na cooperação das crianças durante os procedimentos. Os resultados sugerem que a implementação de brinquedos terapêuticos pode ser uma ferramenta valiosa na prática clínica pediátrica.
Síndrome do ápice orbitário causada por herpes zóster oftálmico: relato de caso e revisão da literatura
Authors: Costa Lucca de Castro , Purper Pedro Paulo Santos , Marin Fernanda Araujo , Silva Júlia Gazotto Rodrigues da , Silva Naylla Gomes da
Published: August 2024

A Síndrome do Ápice Orbitário (SAO) é uma condição rara, caracterizada pela combinação de neuropatia óptica e oftalmoplegia, que pode resultar em perda visual significativa. Esta síndrome pode ser precipitada por diversas etiologias, incluindo infecções virais. Este artigo apresenta um relato de caso de SAO associada ao herpes zóster oftálmico (HZO) em um paciente adulto e realiza uma revisão sistemática da literatura sobre essa associação. A revisão incluiu estudos brasileiros publicados entre 2010 e 2023, utilizando as bases de dados PubMed, Scielo e Lilacs. Os achados destacam a importância do diagnóstico precoce e do manejo adequado da SAO para prevenir complicações graves. O tratamento com antivirais e corticosteroides mostrou-se eficaz na maioria dos casos revisados.
Síndrome lacrimo-auriculo-dento-digital (LADD): relato de caso e revisão da literatura
Authors: Carbone Gabriela Candida de Albuquerque , Ferreira Beatriz Damianci , Rosa Luís Otávio Sousa , Lins Luisa Acioli
Published: August 2024

A Síndrome Lacrimo-Auriculo-Dento-Digital (LADD) é uma condição genética rara caracterizada por anomalias nos sistemas lacrimal, auditivo, dentário e digital. Este artigo apresenta um relato de caso de um paciente diagnosticado com LADD e realiza uma revisão sistemática da literatura, com foco nas características clínicas, genéticas e no manejo da síndrome. A revisão inclui artigos científicos publicados em bases de dados nacionais e internacionais. Os resultados evidenciam a heterogeneidade fenotípica da LADD e destacam a importância do diagnóstico precoce para o manejo adequado das complicações associadas.
Esclerite necrosante por nocardia após ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular: caso clínico e revisão de literatura
Authors: Furieri Fernanda Dias , Dias Matheus Nonato , Cunha Laura Couto , Carneiro Raphael Machado , Oliveira Jean Carlo Carvalho
Published: August 2024

A esclerite necrosante é uma condição inflamatória rara, mas grave, que pode surgir como complicação após procedimentos oculares. Este artigo relata um caso de esclerite necrosante por Nocardia em um paciente submetido à ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular. Além do relato do caso, é apresentada uma revisão sistemática da literatura sobre esta condição. A pesquisa abrange estudos nacionais e internacionais, com ênfase em publicações brasileiras. Os métodos incluem análise de prontuários, exames laboratoriais, e revisão bibliográfica. Os resultados destacam a necessidade de diagnóstico precoce e tratamento adequado para evitar complicações severas. Concluímos que a esclerite necrosante por Nocardia, embora rara, deve ser considerada em pacientes com inflamação ocular persistente após cirurgia, e que o manejo interdisciplinar é essencial para o sucesso terapêutico.
Mapping Terrestrial Conservation: Showcasing Model Assessment for Map Performance Evaluation
Authors:   University of Southern Mindanao, Tabora John Aries , Ancog Rico , Sanchez Patricia Ann , Arboleda Mark Dondi , Lit, Jr. Ireneo , Tiburan, Jr. Cristino
Published: August 2024

Habitat preservation, conservation, and protection of threatened species require careful site selection procedures. The presence of several site-selection models encourages model assessments to determine their usefulness and functionality for conservation purposes. Map model assessments are not conventionally conducted between site selection models to understand the nature of their decision-making strategies and prioritization. Therefore, the objective of this study was to determine the relationship between a recently published site selection model, the Safe Zone with MaxEnt, representing the Species Distribution Model, and the Forest Landscape Integrity Index, representing an intact forest habitat. As expected, there was considerable variation among the three models due to their different algorithms and themes of concern; nevertheless, these had some level of agreement in selecting potential areas for conservation. In addition, this study presented a convenient method for map data collection and the analysis required for a comprehensive understanding of the model agreements and relationships with other models. The nature of the decision making of the Safe Zone model and its potential utility for selecting Strict Protection Zones was presented. This study highlighted the intersection of geospatial analysis, conservation, and model evaluation. Finally, study emphasized the importance of informed decision-making in environmental planning and management through rigorous map assessment. The limitations of this study include the varied pixel resolutions of global and local maps, temporal predictions, and the fact that the models to which the SZ was compared are limited to models and maps available in the area of interest.
Pengaruh Ukuran Perusahaan, Leverage, Likuiditas, dan Perputaran Kas Terhadap Profitabilitas Perusahaan Pariwisata Sebelum dan Selama Pandemi Covid-19
Authors: Ainayah Zhaqiela , Winarso Beni Suhendra
Published: August 2024

Tujuan penelitian ini adalah untuk mengetahui (1) pengaruh Ukuran perusahaan terhadap profitabilitas sebelum dan selama Covid-19, (2) pengaruh leverage terhadap profitabilitas sebelum dan selama Covid-19, (3) pengaruh likuiditas terhadap profitabilitas sebelum dan selama Covid-19, (4) pengaruh perputaran kas terhadap profitabilitas sebelum dan selama Covid-19. Sampel dalam penelitian ini adalah perusahaan pariwisata yang terdaftar di BEI dengan jumlah sampel digunakan dalam penelitian ini sebelum Covid-19 berjumlah 46 perusahaan dan selama Covid-19 berjumlah 67 perusahaan. Hasil penelitian ini menunjukkan ukuran perusahaan yang diproksikan oleh SIZE berpengaruh positif dan signifikan terhadap profitabilitas sebelum Covid-19 (2018-2019), sedangkan leverage, likuiditas dan perputaran kas sebelum Covid-19 (2018-2019) tidak berpengaruh terhadap profitabilitas. Ukuran perusahaan, leverage, likuiditas dan perputaran kas selama Covid-19 (2020-2022) tidak berpengaruh terhadap profitabilitas.
Aplikasi Penjualan Tas Di Indonesia Berbasis Web Menggunakan Metode Waterfall
Authors: Fitriyanto Ade , Fitrani Arif Senja
Published: August 2024

Penelitian ini bertujuan untuk mengembangkan aplikasi penjualan tas berbasis web di Tanggulangin, Kabupaten Sidoarjo, dengan menggunakan metode Waterfall. Metode Waterfall digunakan untuk mengembangkan sistem informasi secara berurutan, mulai dari analisis, desain, implementasi, pengujian, dan pemeliharaan. Penelitian ini dilakukan di Laboratorium Informatika Universitas Muhammadiyah Sidoarjo. Data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Data primer diperoleh melalui wawancara dan kuisioner, sedangkan data sekunder diperoleh dari studi literatur. Hasil penelitian menunjukkan bahwa aplikasi penjualan tas berbasis web yang dikembangkan dapat memberikan kemudahan bagi pembeli dalam pemesanan produk tas yang dilakukan kapan saja dan dari mana saja. Aplikasi ini juga dapat memberikan kemudahan bagi pemilik dalam memantau informasi mengenai manajemen pengelolaan data. Kesimpulan dari penelitian ini adalah aplikasi penjualan tas berbasis web dapat menjadi solusi yang tepat untuk meningkatkan efisiensi dan efektivitas dalam penjualan tas.
Perancangan dan Pembuatan Sistem Informasi Berbasis Website Untuk Sales Marketing
Authors: Pratama Robby , Eviyanti Ade
Published: August 2024

PT: Indonesia Comnets Plus (ICON+) merupakan perusahaan yang bergerak di bidang telekomunikasi yang membutuhkan sistem informasi untuk mengelola data sales marketing. Sistem informasi yang ada saat ini masih manual dan tidak efisien, sehingga menghambat kinerja sales marketing. Penelitian ini bertujuan untuk merancang dan membangun sistem informasi berbasis website untuk sales marketing di PT. ICON+. Penelitian ini menggunakan metode kualitatif dengan studi kasus. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa sistem informasi yang dirancang dan dibangun dapat membantu PT. ICON+ dalam mengelola data sales marketing dengan lebih efektif dan efisien. Sistem informasi ini diharapkan dapat membantu PT. ICON+ dalam meningkatkan kinerja sales marketing dan mencapai target penjualan.
PENGARUH BUDAYA ORGANISASI, MOTIVASI, PELATIHAN DAN PENGELOLAAN DANA DESA TERHADAP KINERJA PEMERINTAH DESA BERDASARKAN PERSEPSI APARATUR DESA
Authors: Putri Novitasari Anggraeni , Yuliantoro Rohmad
Published: August 2024

Penelitian ini dilakukan untuk menganalis persepsi aparatur desa mengenai Budaya Organisasi, Motivasi, Pelatihan, Pengelolaan Dana Desa terhadap Kinerja Pemerintahan Desa diwilayah Kecamatan Rembang Kabupaten Purbalingga. Penelitian ini menggunakan metode kuantitatif dengan data yang diperoleh dari kuesioner dengan metode convenience sampling. Subjek dari penelitian ini adalah aparatur pemerintah desa yang berada di Kecamatan Rembang Kabupaten Purbalingga. Penelitian ini menggunakan sampel sebanyak 120 responden yang dipilih secara tertentu yang terdapat di 12 desa. Alat analisis dalam penelitian ini menggunakan SPSS versi 24.0. Hasil dari penelitian ini, budaya organisasi, motivasi, pelatihan, dan pengelolaan dana desa berpengaruh terhadap kinerja pemerintahan desa.
Pengaruh Word Of Mouth, Lokasi dan Kualitas Pelayanan Terhadap Keputusan Pembelian Konsumen Warmindo
Authors: Yahya Baharuddin , Yuniarto Arif Sapta
Published: August 2024

Penelitian ini berjudul pengaruh word of mouth, lokasi dan kualitas pelayanan terhadap keputusan pembelian konsumen Warmindo di Yogyakata. Tujuan penelitian ini adalah untuk menguji dan menganalisis pengaruh word of mouth, lokasi dan kualitas pelayanan terhadap keputusan pembelian konsumen warmindo maharasa. Jenis penelitian ini adalah penelitian kuantitatif. Populasi dalam penelitian ini adalah konsumen yang sudah melakukan pembelian pada Warmino di Yogyakarta. Jumlah sampel dalam penelitian ini adalah sebanyak 100 responden. Teknik pengambilan sampel menggunakan convenience sampling. Teknik pengumpulan data menggunakan kuesioner dan menggunakan skala likert sebagai model pengukurannya. Penelitian ini diolah menggunakan SPSS versi 25 untuk uji instrumen, uji persyaratan analisis, analisis data dan uji hipotesis. Berdasarkan hasil kesimpulan dalam penelitian ini dapat dijelaskan sebagai berikut: Word of Mouth berpengaruh positif dan signifikan terhadap penggunaan Keputusan Pembelian Konsumen Warmindo. Lokasi tidak berpengaruh positif terhadap Keputusan Pembelian Konsumen Warmindo. Kualitas Pelayanan berpengaruh positif dan signifikan terhadap Keputusan Pembelian Konsumen Warmindo.
Analisis Kepuasan dan Loyalitas Konsumen Produk Minuman Teh di Kedai Dichaian di Cikarang Utara Kabupaten Bekasi
Authors: Prihaswara Agata , Abubakar Abubakar , Mahatmayana I Ketut Manu
Published: August 2024

Penelitian ini bertujuan untuk mengukur tingkat loyalitas konsumen di Kedai Dichaian, Cikarang Utara. Lokasi penelitian dipilih secara sengaja menggunakan metode purposive sampling untuk memastikan kesesuaian dengan tujuan penelitian. Teknik pengambilan sampel yang digunakan adalah non probability sampling, khususnya accidental sampling. Berdasarkan perhitungan dengan rumus Lemeshow, diperlukan 96 responden, namun jumlah ini dibulatkan menjadi minimal 100 responden. Responden yang dipilih adalah konsumen Kedai Dichaian yang telah membeli teh lebih dari sekali. Pengumpulan data dilakukan melalui dua sumber utama: data primer dan data sekunder. Data primer diperoleh melalui wawancara dan kuesioner yang diberikan langsung kepada konsumen. Data sekunder diperoleh dari studi literatur yang mencakup buku, publikasi dari Badan Pusat Statistik, jurnal ilmiah, serta sumber-sumber internet yang relevan. Hasil penelitian menunjukkan berbagai tingkat loyalitas konsumen di Kedai Dichaian. Ditemukan bahwa 46% responden termasuk dalam kategori switcher buyer, 41% merupakan habitual buyer, 78% adalah satisfaction buyer, 50% menunjukkan liking the brand, dan 40% termasuk dalam kategori committed buyer. Temuan ini memberikan wawasan tentang profil loyalitas konsumen yang dapat digunakan untuk meningkatkan strategi pemasaran dan mempertahankan pelanggan di Kedai Dichaian.
Kebijakan Investasi Terhadap Nilai Perusahaan di Indonesia
Authors: Syahidah Zahwa Tiara , Zulfania Zulfania , Afriyanti Suci , Nurseha Siska , Fadilla Arif
Published: August 2024

Penelitian ini bertujuan untuk menginvestigasi efek dari Kebijakan Investasi Terhadap Nilai Perusahaan menggunakan sampel perusahaan di Indonesia. Data yang digunakan adalah nilai perusahaan yang dikumpulkan untuk menganalisis pengaruh kebijakan investasi terhadap nilai perusahaan di Indonesia. Hasil penelitian menunjukkan bahwa kebijakan investasi memiliki pengaruh signifikan pada nilai perusahaan. Faktor-faktor seperti regulasi investasi, stabilitas politik, dan kondisi ekonomi memainkan peran penting dalam membentuk nilai investasi. Penelitian ini memberikan kontribusi penting bagi pemahaman tentang hubungan antara kebijakan investasi dan nilai perusahaan di Indonesia.
Determinan Kinerja Keuangan Perusahaan Otomotif di Indonesia
Authors: Irfani Badar , Ainy Rintan Nuzul
Published: August 2024

Dalam konteks globalisasi, perusahaan dituntut untuk meningkatkan profesionalitas dan kualitas pengelolaan guna menghadapi persaingan yang semakin ketat. Salah satu upaya yang dilakukan adalah dengan menerapkan good corporate governance (GCG) atau tata kelola perusahaan yang baik, yang semakin populer di Indonesia. Penelitian ini menganalisis peran spesifik dewan komisaris, dewan direksi, dan komite audit dalam meningkatkan kinerja keuangan perusahaan. Hasil penelitian menunjukkan bahwa keberadaan dewan komisaris independen, dewan direksi, dan komite audit yang efektif berkontribusi positif terhadap kinerja keuangan perusahaan. Selain itu, penelitian ini mengeksplorasi pengaruh struktur kepemilikan dan ukuran perusahaan terhadap kinerja keuangan. Struktur kepemilikan dan ukuran perusahaan ditemukan memiliki dampak signifikan terhadap kinerja perusahaan, dengan implikasi penting bagi perancangan struktur kepemilikan dan strategi pertumbuhan.Penelitian ini memberikan wawasan mendalam tentang penerapan GCG dalam industri otomotif di Indonesia, yang memiliki prospek cerah dan peran penting dalam pembangunan ekonomi nasional. Pemahaman yang lebih baik tentang GCG di sektor ini dapat membantu mengidentifikasi praktik terbaik yang dapat diterapkan untuk meningkatkan kinerja keuangan dan operasional perusahaan otomotif. Temuan penelitian ini diharapkan dapat menjadi panduan bagi perusahaan dalam memperkuat tata kelola mereka untuk mencapai hasil yang lebih baik.
Importance of Tourism in the Economic Development of Uzbekistan
Authors: Tursinbaevich Adilchaev Rustem
Published: August 2024

This study explores the role of tourism in the economic development of Uzbekistan. It discusses the different types of tourism, reforms in the sector, and the potential impact of tourism on raising the morale of the people. The study aims to provide insights into the tourism industry's contribution to the national economy and its importance for cultural and economic development.
Improving Supervisory Consultant Performance in Construction Projects: Assessments in the LKPP's SIKaP Application for Enhanced Efficiency
Authors: Heston Yudha Pracastino , Wulandari Mariana , Fernando Robi
Published: August 2024

This article focuses on enhancing the performance of supervisory consultants in construction projects through assessments conducted in the LKPP's SIKaP application. Supervision plays a crucial role in ensuring the smooth execution of construction activities and addressing potential obstacles. The quality and safety of construction operations have become increasingly important, necessitating effective supervision. The article highlights the importance of conducting assessments to measure the success of supervisory consultants in meeting project objectives and adhering to established standards. It emphasizes the evaluation of various performance criteria, including human resources, equipment, materials, costs, time, and quality. The assessment process enables the identification of strengths and weaknesses, facilitating corrective measures and improving future performance. The article also emphasizes the interconnectedness of construction supervision and project management, with project management playing a pivotal role in achieving project goals. Communication management is highlighted as a crucial aspect for effective project execution. The regulatory framework governing technical supervision activities in construction projects is discussed, along with the roles and responsibilities of construction management and construction supervision service providers. The article emphasizes the importance of on-site inspections, project administration, progress monitoring, and quality management in construction supervision. Lastly, the article discusses the evaluation of providers' performance in goods/services procurement, emphasizing the importance of quality, cost efficiency, and adherence to standards. The implementation of the SIKaP application is seen as a means to enhance transparency, accountability, and project quality in the construction industry, fostering a culture of continuous improvement and industry benchmarking.
Automated cutaneous squamous cell carcinoma grading using deep learning with transfer learning
Authors:   Department of Pathology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Buruiană Alexandra , Şerbănescu Mircea-Sebastian ,   Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; Department of Pathology, Philanthropy Municipal Clinical Hospital, Craiova, Romania, Pop Bogdan ,   Department of Pathology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Gheban Bogdan-Alexandru ,   Department of Histology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Pathology, Emergency Clinical County Hospital, Cluj-Napoca, Romania, Georgiu Carmen ,   Department of Pathology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Pathology, Emergency Clinical County Hospital, Cluj-Napoca, Romania, Crişan Doiniţa ,   Department of Pathology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Pathology, Emergency Clinical County Hospital, Cluj-Napoca, Romania, Crişan Maria ,   Department of Histology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Clinic of Dermatology, Emergency Clinical County Hospital, Cluj-Napoca, Romania
Published: August 2024

Introduction: Histological grading of cutaneous squamous cell carcinoma (cSCC) is crucial for prognosis and treatment decisions, but manual grading is subjective and time-consuming. Aim: This study aimed to develop and validate a deep learning (DL)-based model for automated cSCC grading, potentially improving diagnostic accuracy (ACC) and efficiency. Materials and Methods: Three deep neural networks (DNNs) with different architectures (AlexNet, GoogLeNet, ResNet-18) were trained using transfer learning on a dataset of 300 histopathological images of cSCC. The models were evaluated on their ACC, sensitivity (SN), specificity (SP), and area under the curve (AUC). Clinical validation was performed on 60 images, comparing the DNNs’ predictions with those of a panel of pathologists. Results: The models achieved high performance metrics (ACC>85%, SN>85%, SP>92%, AUC>97%) demonstrating their potential for objective and efficient cSCC grading. The high agreement between the DNNs and pathologists, as well as among different network architectures, further supports the reliability and ACC of the DL models. The top-performing models are publicly available, facilitating further research and potential clinical implementation. Conclusions: This study highlights the promising role of DL in enhancing cSCC diagnosis, ultimately improving patient care.