bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberian ekstrak lada hitam (Piper nigrum L.) untuk menekan laju pertumbuhan kontaminan pada kultur in vitro tanaman kentang (Solanum tuberosum)
Authors: Hasrawati Hasrawati , Masriany Masriany , Hafsan Hafsan , Nur Fatmawaty
Published: January 2023

Kentang (Solanum tuberosum) yaitu tanaman pangan yang penting di dunia selain padi dan gandum. Salah satu kendala dalam peningkatan produksi kentang adalah ketersediaan benih yang bermutu yang jumlahnya terbatas dan belum memenuhi kebutuhan petani. Oleh karena itu untuk mengatasi masalah tersebut diperlukan benih kentang unggul bebas virus yang dihasilkan dari teknik kultur in vitro dalam bentuk planlet. Lada hitam (Piper ningrum L.)memiliki kandungan senyawa kimia berupa flavonoid yang memiliki kemampuan sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak lada hitam sebagai antibiotik alami dalam menghambat pertumbuhan bakteri dan jamur pada kultur jaringan tanaman kentang. Penelitian ini dilakukan secara eksperimental dengan 5 perlakuan yaitu K0: Kontrol negatif (Media MS), K1: Media MS dan Novachlor (kontrol posistif), K2: Media MS dan ekstrak lada hitam 5 ml/l, K3: Media MS dan ekstrak lada hitam 10 ml/l dan K4: Media MS dan ekstrak lada hitam 15 ml/l. Hasil penelitian menunjukkan bahwa perlakuan ekstrak lada hitam yang memberikan pengaruh terbaik adalah ekstrak lada hitam 5 ml/l, yaitu mampu menekan pertumbuhan kontaminan jamur dan bakteri pada kultur in vitro tanaman kentang. Studi ini dapat menjadi informasi awal untuk menjadikan ekstrak lada hitam sebagai kandidat antibiotik untuk menekan kontaminan pada kultur tanaman secara in vitro.
Analisa kualitas air pada calon induk udang Vaname Litopenaeus vannamei (Boone, 1931) di Balai Perikanan Budidaya Air Payau (BPBAP) Takalar
Authors: Janna Mivtahul , Sijid St. Aisyah , Hasmawati Hasmawati
Published: January 2023

Kualitas air merupakan salah faktor mempengaruhi keberlangsungan udang Vaname (Litopenaeus vannamei). Oleh karena itu, sangat diperlukan untuk tetap memperhatikan kualitas air, meliputi salinitas, suhu, oksigen terlarut, dan pH yang layak di tambak perairan dengan cara melakukan pengujian secara berkala. Tujuan penelitian yaitu untuk mengetahui kondisi kualitas air pada calon induk udang Vaname di Balai Perikanan Budidaya Air Payau (BPBAP) Takalar. Adapun metode yang digunakan dalam penelitian ini yaitu model indoor yang sesuai SNI 8037.1:2014 dengan memperhatikan suhu, pH air dan salinitas dalam angka yang layak untuk pemeliharaan induk udang Vaname. Hasil yang diperoleh yaitu suhu berkisar antara 26-28 ºC, pH 7-8, oksigen terlarut (DO) 7-9 mg/l, salinitas 20-33 ppt dan alkalinitas 108- 110 ppm
The role of maize variety (Zea mays L.) in shaping the grain vitamin content
Authors: Szulc Piotr , Ambroży-Deręgowska Katarzyna , Kobus-Cisowska Joanna , Kardasz Przemysław , Nowaczyk Rafał
Published: January 2023

The Faculty of Agronomy at the University of Life Sciences in Poznań conducted laboratory tests on the content of B vitamins in the grain of three varieties of yellow-colored fodder maize. The grains of the variety ES Metronom had the statistically significantly highest content of vitamins B1 and B9. In the case of vitamin B3, the significantly highest concentration was recorded in the grain of the variety ES Abakus, while the lowest concentration was found for the variety ES Metronom. In contrast, the grain of the variety ES Bombastic had significantly higher vitamin B6 content than that of the varieties ES Abakus and ES Metronom. The grain of the variety ES Metronom had significantly higher vitamin B9 content than the other two varieties tested. In general, it should be concluded that the content of B vitamins in maize grain is not determined by the type of maize hybrid.
Green extraction of bioactive compounds from Azadirachta indica in aqueous glycerol and modelling and optimisation by response surface methodology
Authors: Anis Mahnoor , Ahmed Dildar , Anis Nida
Published: January 2023

Development of efficient and green methods for extracting bioactive phytochemicals has great industrial value. Increasing environmental sensitivity at the global level has tremendously enhanced the demand for such methods. Azadirachta indica is a well-known medicinal tree. As glycerol has emerged as a green and safe extraction solvent for bioactive phytochemicals, this study aimed to investigate the efficacy of a glycerol–water solvent system to extract bioactive compounds from A. indica leaves. Modelling and optimisation were carried out by using response surface methodology (RSM) as per the Box–Behnken design with three variables, namely, solvent concentration, time and temperature. The responses were total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and metal chelating activity (MCA). The optimum conditions found by numerical optimisation were a solvent concentration of 69.713%, a time period of 38.328 min and a temperature of 32.114 °C with the predicted values of TPC, TFC, %DPPH and %MCA as 5.27 mg gallic acid equivalents · g−1 DW (dry weight), 9.869 mg rutin equivalents · g−1 DW, 73.8% and 54.366%, respectively. The validation experiments showed almost the same results for each response with very low% errors (5.431–7.661). Increasing glycerol concentration in the extracting medium favoured the extraction of TPC, TFC and antioxidant phytochemicals, but for MCA, the trend was the opposite. In conclusion, 70% aqueous glycerol is an effective medium for the extraction of polyphenolic and antioxidant phytochemicals from A. indica leaves. Extraction models suggested by RSM have high prospects to be used on a large industrial scale.
The effect of ethanol extract of kirinyuh leaf (Chromolaena odorata L) on the allergy healing of rabbit (lepus curpaneums)
Authors: TR Teuku Husni , ISMAİL Ikbal , MAURİEZA Keıshya
Published: January 2023

Allergic rhinitis is one of the world's most common diseases and remains alive. The following diseasesare often found in otorhinolaryngology and constitute a significant health problem worldwide. Symptoms of nasalhyperactivity and hyperresponsiveness are caused by the role of eosinophils, basophils, neutrophils, and otherinflammatory mediators. The development of medicinal plants in other countries is overgrowing due to manyadverse drug reactions. Chromolaena odorata (L) has been used as a traditional medicine because it hasethnopharmacology effects such as alkaloids, essential oils, phenolics, flavonoids, steroids, phenolic compounds,glycosides, phytates, saponins and tannins which are suppress allergenic. To determine the effect of ethanol extractointment of kirinyuh leaves (Chromolaena odorata (L)) on the levels of eosinophils, basophils, and neutrophils ofallergic that induced in a rabbit nasal mucosa. Experimental research with a pretest-posttest control group designuses rabbits as a research subject. The extract of ethanol ointment from Chromolaena odorata (L) leaf can reduce thenasal mucosa's allergen response. One-way ANOVA statistical analysis showed no significant difference in thenumber of inflammatory cells between basophils, eosinophils, and neutrophils (p0.05;1.00). Furthermore, based onthe analysis of the Kruskal Wallis Test, it showed that there were differences in the number of inflammatory cellsbased on the concentration of the test material, related to the allergen response (p0.05; 0.024) with a strongrelationship (r=0.907). Extracting ethanol ointment from Chromolaena odorata (L) leaf, which is applied topically,can reduce allergic reactions and inflammation.KEYWORDS: allergic rhinitis, eosinophils, basophils, neutrophils, Chromolaena odorata (L)
A study of the clinical toxicity of methotrexate in the Taif region: a case report
Authors: Alhusayni Khalid , Alanazi Ibrahim , Dighriri Ibrahim , Alnazzawi Ahmed , Rashed Ozoof , Alharthi Faisal , Mashi Fawaz , Ogdy Nabeel , Sulimani Mohammed , Alzahrani Mohammad , Alghamdi Mohannd , Almalki Sami , Alzaidi Khalid , Alqurashi Ghadi , Alqurashi Fahad
Published: January 2023

Background: The first report, written by Sidney Farber in 1948, detailed his success in the use of methotrexate (MTX) for the treatment of leukemia in children. The drug was used for the first time in 1951 for the treatment of rheumatoid arthritis and psoriasis. MTX classical antifolate, also known as amethopterin, is 4-amino-4- dcoxy-Na-methyl folic acid. The correlation between toxic reactions and the pharmacokinetics of MTX discloses certain time- and concentration-dependent relationships that appear to determine which target tissue is at risk for toxicity, whether toxicity will occur and the severity of MTX toxicity. A high dose of MTX (HDMTX) is defined as more than 500 mg/m2 or if given intravenously.
Case Presentation: HDMTX can cause significant toxicity, including myelosuppression, mucositis, hepatotoxicity and, in severe cases, may cause multiorgan failure.
Conclusion: An early understanding of the causes and risk factors for MTX toxicity may be beneficial in reducing the occurrence of MTX toxicity in the Taif region.
Monogenic forms of childhood obesity: a review
Authors: Asiri Sultan , Alqarni Razan , Alkhaldi Njoud , Alharbi Njoud , Alkhayal Shaden , Alghamdi Ghadeer , Alghamdi Waad , Al-Taleb Maram , Aldrees Meshael
Published: January 2023

Childhood obesity has become a notable health concern in the world. According to American Medical Association, obesity is defined as having a body mass index greater than 30 kg/m2. Childhood obesity is classified into three main categories, polygenic obesity, which is the most common form; followed by monogenic obesity, which is rare; and non-syndromic obesity. The management of childhood obesity is complex and requires a multidisciplinary approach. For monogenic obesity, several treatment options have been investigated. Long-term body weight maintenance is challenging. This review aimed to provide an overview of monogenic obesity, its mechanisms, evaluation, and treatment options. Monogenic forms of childhood obesity are rare. However, early diagnosis using whole-exome sequencing is needed to identify the causes of obesity and its associated anomalies for subsequent treatment. In addition, the early initiation of a multidisciplinary management approach is essential to prevent long-term morbidity and mortality. Several new treatment options have recently emerged, which could, in combination with lifestyle modifications, provide a favorable outcome for patients with non-syndromic forms of obesity.
Gender Influence on the Pronunciation of Stress by Iraqi and Kurdish EFL Learners
Authors: Al – Thalab Hasan Shaban Ali , Abdalla Jihan Kareem
Published: January 2023

Stress is one of the main linguistic aspects that deals with greater effort on a syllable or syllables in a word and making them more prominent than other unstressed syllables. This phonetic and phonological feature is probably present in most languages of the world. The present study presents lexical stress patterns influence on Iraqi Arabic and Kurdish EFL learners’ pronunciation.  The study aims at investigating EFL learners’ pronunciation of English lexical stress by three different language groups, to show the effect of first language on the pronunciation of English words concerning Iraqi Arabic and Kurdish EFL learners, clarifying the influence of gender on their performance. The current study hypothesizes the following for the current aim to be achieved: . there is no difference in gender in the performance of all language groups. Lastly, the validity of the data is analyzed acoustically by using Praat software program to verify the auditory analysis and to make certain that stress assignment is precise. Among the conclusions arrived at in the present study is that the total performance of Kurdish participants is better than the Iraqi Arabic performance, but there is no significant difference between them.
Resistant to refractory hypertension: Angiotensin receptor blocker/neprilysin inhibitor to the rescue
Authors: Okeahialam Basil Nwaneri
Published: January 2023

Hypertension in African starts early and runs a severe course; with appalling morbi-mortality statistics. When resistant to treatment, again a phenotype more common in the African, outcome is poorer. Search for effective management has continued, ranging from novel pharmacological agents to devise therapy. The latter is invasive and beyond the reach of many needing it. Angiotensin receptor blocker/Neprilysin inhibitors are relatively new in our environment and effective in hypertensives with high salt intake and sensitivity. Since this is the situation with majority of African hypertensives, it was given to a patient with diabetes and treatment resistant hypertension of the refractory phenotype. The outcome was satisfactory hence this case report.
ADVANTAGES OF COSSACK FLANKING IN THE PHYSICAL EDUCATION PROGRAM AMONG THE STUDENTS OF A SPECIAL MEDICAL GROUP
Authors:   Kyiv National University of Construction and Architecture, Shamych Oleksandr , Ozerova Olga ,   Kyiv National University of Construction and Architecture, Klimenko Taras ,   Kyiv National University of Construction and Architecture, Kyselevska Svitlana ,   Kyiv National University of Construction and Architecture, Naumets Yevhen ,   Kyiv National University of Construction and Architecture
Published: January 2023

This article focuses on physical education in Ukrainian universities in modern crisis conditions. The significance of the problem is in the factors which reduce the level of motivation of students during the studying process, as well as in finding the solution to this problem. The purpose and objectives of the study are to promote this type of motor activity, such as flanking with Cossack weapons. We have developed the program on flanking technical basic elements mastering for the special medical group students. The expediency of this program implementation in the process of physical education in universities and colleges has been scientifically substantiated.
INCREASING THE NUTRITIONAL VALUE OF MOUSSE BY ADDING WHEY PROTEIN CONCENTRATE AND RASPBERRY SUBLIME
Authors:   National University of Food Technologies, Dukhovnikova Kateryna , Niemirich Oleksandra ,   National University of Food Technologies, Mamchenko Liudmyla ,   National University of Food Technologies, Havrysh Andrii ,   National University of Food Technologies
Published: January 2023

The article presents the technology of mousse using whey protein concentrate and sublimated raspberry powder. According to the results of the study, it was established that the use of concentrate contributes to an increase in the protein content of the finished dish by 9,51%, and the use of sublimated raspberry powder enriches the mineral and vitamin composition of the mousse, in particular, the content of potassium, calcium, phosphorus, iron, vitamins of group B. During the analysis of organoleptic quality indicators, an improvement in the consistency and taste of the finished mousse was noted. The data presented in the article prove the expediency of using whey protein concentrate and sublimated raspberry powder in mousse technology to expand the range of balanced sweet dishes in modern restaurants.
Spike Proteins Problems - Four Case Reports
Authors:   Head of Holistic Center, 13 Haupt St., Abtwil 9030, Switzerland, D Manfred
Published: January 2023

Spike proteins are proving to be an ever-increasing problem in the context of Covid-19 infections. Therefore, here are four case reports.
Thorn in my Side - A Case of Entrapped, Intra-uterine Foreign Body and Delayed, Atypical Pelvic Inflammatory Disease
Authors:   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Australia, A Aboda , H Kim ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Australia, B Xu ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Australia, B McCully ,   Department of Obstetrics & Gynaecology, Mildura Base Public Hospital, Australia
Published: January 2023

Uterine foreign bodies are a rare, but important cause of infertility and pelvic pain. Due to their relative scarcity, the diagnosis may be either missed or simply not considered as contributory to aetiology when patients present with symptoms. We report the case of a 42-year-old woman diagnosed with Atypical Pelvic Inflammatory Disease (APID). She presented with lower abdominal pain, vaginal discharge and inflammatory markers consistent with acute infection. Paradoxically, diagnostic imaging revealed an unsuspected intrauterine foreign body. The significance of this to the presenting complaint was initially uncertain however conservative management with antibiotics alone was sufficient to allow complete recovery. Later, the patient consented to operative hysteroscopy which identified and removed the object which was shown by histology to be a residual bone fragment derived most probably, from retained products of conception. The patient was noted to have had a surgical termination of pregnancy 5 years prior.
Gastric Diverticula: An Uncommon Finding
Authors:   Department of Radiology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, H Adil , S Choayb ,   Department of Radiology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, J El Fenni ,   Department of Radiology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, I En-Nafaa ,   Department of Radiology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Published: January 2023

Gastric Diverticula (GD) are extremely uncommon. They define as an out pouching of the gastric wall to form a sac-like structure. They can be congenital or acquired and are mostly located on the posterior surface of the gastric fundus. GD is asymptomatic in general; however, they may present with discomfort or vague abdominal pain. Rarely, GD can be revealed by a complication, such as ulceration, perforation, or hemorrhage. Abdominal CT scan demonstrates a thin-walled, cystic lesion located in the posterior wall of the fundic region. It may sometimes contain air bubbles or air-fluid level. Communication with the gastric lumen is easily demonstrated by ingesting a water-soluble contrast. Differential diagnosis includes adrenal, pancreatic, and renal cysts, duplication cysts, and bowel diverticula.
Ondansetron in a Paxlovid Intolerant Man
Authors:   College of Undergraduate Science, Nova SE University, Davie, Fl, USA, LG Cubeddu , TM Dalley ,   Department of Emergency Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA, LX Cubeddu ,   Health Professions Division, Nova SE University, Davie, FL, USA
Published: January 2023

A symptomatic 22-year-old man, unvaccinated and living with high-risk elder parents, was prescribed nirmatrelvir/ritonavir (Paxlovid®) after testing positive for COVID-19. The patient developed persistent moderate to severe nausea after the first dose, progressing to severe nausea and several vomiting episodes after the second dose. To avoid discontinuing Paxlovid, a trial with ondansetron8 mg PO, was initiated, with the first dose given one hour after the last vomiting episode. Due to the improvement in nausea and absence of retching and vomiting, treatment was continued at a dose of 8 mg PO, twice daily, 1-2 hours before each Paxlovid dose, and maintained until completion of the five-day antiviral treatment. No nausea or vomiting was reported during treatment with ondansetron. In COVID-19 patients intolerant to Paxlovid, due to development of moderate to severe nausea and vomiting, use of ondansetronmay prevent treatment discontinuation, and allow completion of the recommended course of therapy. Ondansetron is not expected to exert drug-interactions with the nirmatrelvirritonavircombination.
A Case of Toxic Megacolon and Acute Appendicitis in HIV/AIDS
Authors:   Department of Surgery, University of Buea, Regional Hospital Limbe, Cameroon, EP Weledji , MM Takere ,   Department of Surgery, University of Buea, Regional Hospital Limbe, Cameroon, P Fon ,   Department of Surgery, University of Buea, Regional Hospital Limbe, Cameroon
Published: January 2023

A 33-year-old African man with HIV/AIDS presented with an acute abdomen associated with rectal bleeding. Colonic decompression, appendicectomy and post operative antiviral therapy for a diagnosed CMV colitis/ megacolon and appendicitis complicating AIDS was effective and avoided the morbidity and high mortality from an emergency subtotal colectomy and ileostomy.
Long Term Survival of Chronic Myeloid Leukemia Patients with Chromosomal Aberrations in Philadelphia Negative Metaphases During Treatment with Tyrosine Kinase Inhibitors
Authors:   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, C Varelas , G Papaioannou ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, E Gavriilaki ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, M Gkaitatzi ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, T Touloumenidou ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, C Vadikoliou ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, C Lalayanni ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, N Stavroyianni ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, A Papalexandri ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, I Batsis ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, I Sakellari ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, A Anagnostopoulos ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece, A Athanasiadou ,   Hematology & HCT Unit, General Hospital “George Papanikolaou”, Thessaloniki, Greece
Published: January 2023

Additional clonal aberrations (ACAs) in Philadelphia negative metaphases of Chronic Myeloid Leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) were an early noticed event in the course of the treatment plan. However, their biological and clinical implications are not conclusive. In the present study, we investigated their incidence and impact on the prognosis and treatment response. Among 200 CML patients treated in our Department from 2002 to 2019, ACAs in Ph- cells were found in 21 (10.5%), with a median time from initiation of TKIs at 58 months. In addition to monosomy 7, trisomy 8 and loss of chromosome Y, we also identified other numerical and structural abnormalities including add(6)(q27), t(4;15)(q31;q26) t(2;10)(q23;q24), which have never been reported before. We noticed that the number of ACAs developed in Phcells is associated to the number of treatments before the initiation of TKIs. Probability of long-term overall survival at 15 years was 87.1%. Persistent clones were revealed in eight patients. As a result, our study indicates that Ph- ACAs do not impact the outcomes of CML. Aberrations such as monosomy 7 need close monitoring due to their association with increased risk of evolution to myelodysplastic syndrome or acute leukemia.
The Importance of Hope for Quality of Life in patients with Multiple Sclerosis
Authors:   William James Center for Research, ISPA - Instituto Universitário, Lisbon, Portugal, JL Pais Ribeiro , L Pedro ,   Centro de Investigação em Saúde e Tecnologia, Escola Superior de Tecnologia da Saúde de Lisboa - Instituto Politécnico de Lisboa
Published: January 2023

Aims: This study intent to describe the importance of Hope for Quality of Life in patients with Multiple Sclerosis. Evidence has indicated that Hope is important as a buffer between risk factors, physical and psychological health status and quality of life for patients with multiple sclerosis. Methods: The study was exploratory and descriptive. Setting: A general Hospital in Lisbon Portugal. Participants: 280 patients with Multiple Sclerosis. We explore the relationship between Hope and Quality of Life. The instruments used are Multiple Sclerosis Quality of Life scale (MSQol-54) and the Hope Scale. Results: The correlation between Hope scale and the domains of MSQOL-54: Physical Health (r=0.24, p<0.05), Physical Role Limitations (r=0.25, p<0.05), Emotional Role Limitations (r=0.35, p<0.05), Pain (r=0.28, p<0.05),Well-being (r=0.48, p<0.01), Energy (r=0.42, p<0.01), Health in General (r=0.41, p<0.01), Social Function (r=0.45, p<0.01), Cognitive Function (r=0.28, p<0.05), Health Distress (r=0.52, p<0.01), Overal Qol (r=0.49, p<0.01), Sexual function (r=0.33, p<0.05), Change in Health (r=-0.17, p<0.05), and Satisfaction with sexual function (r=0.33, p<0.05). Conclusions: There is a statistically significant correlation between the variables, suggesting that Hope can play an important role in the Quality of Life of patients with multiple sclerosis especial in domains as perception of Wellbeing, Health in General and Social Function and Distress.
Endogenous Endophthalmitis - A Rare Complication of Infective Endocarditis: A Case Report
Authors:   Ophthalmologist, Morocco, E Afaf , H Fatimaezahra ,   Ophthalmologist, Morocco, T Habiba ,   Ophthalmologist, Morocco, A Elhassan ,   Professor of Ophthalmology, Morocco, A Berraho ,   Professor of Ophthalmology, Morocco
Published: January 2023

Endogenous endophthalmitis (EE) is a severe, acute and diffuse uveitis caused by intraocular haematogenic infection. It affects vulnerable subjects. We report a case of a 42-year-old male with a history of endocarditis. he developed endogenous endophthalmitis in her left eye due to acute endocarditis. Owing to deterioration of the general status, intravitreal injections couldn’t be practiced and therapy consisted only in intravenous antibiotic therapy. We highlight the severity of this disease, associated with unfortunate visual and vital prognosis.
Behçet’s Disease Occlusive Vasculitis Progressing to Prepapillary Neovascularization
Authors:   Hôpital des spécialités de Rabat, Morocco, HF Ezahra , T Habiba ,   Hôpital des spécialités de Rabat, Morocco, E-R Afaf ,   Hôpital des spécialités de Rabat, Morocco, B Ahmed ,   Hôpital des spécialités de Rabat, Morocco, S Louai ,   Hôpital des spécialités de Rabat, Morocco, A El Hassan ,   Hôpital des spécialités de Rabat, Morocco, B Amina ,   Hôpital des spécialités de Rabat, Morocco
Published: January 2023

53-year-old man who had recurrent oral and genital aphthous, who consulted urgently for bilateral uveitis that is currently active on the right eye with central and peripheral occlusive vasculitis. The patient was diagnosed with behet’s disease in front of the inflammatory syndrome, ocular involvement and bipolar aphtosis. The management was early based on bolus of methylprednisolone and immunosuppressant, argon laser of ischemic areas. Unfortunately, the evolution was unfavorable with the appearance of prepapillary neovessels and persistence of the macular edema having required several intravitreal injections of anti-VEGF and urgent sessions of PRP with argon laser.
Posterior Scleritis Simulating a Vogt-Koyanagi-Harada Syndrome
Authors:   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, M Aachak , H Brarou ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, H Boui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, T Abdellaoui ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, F El Asri ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, Y Mouzarii ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, K Reda ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco, A Oubaaz ,   Department of Ophthalmology, Military Hospital, Mohammed V University, Rabat, Morocco
Published: January 2023

A 35 years old patient presented with complaints of diminution of vision in the right eye with ocular pain without any redness nor other clinical signs. Ophthalmic examination revealed a best corrected VA of counting fingers in the right eye. Slit lamp examination of the RE was normal. Fundus evaluation revealed a grade II papillary edema with macular retinal folds (Figure 1).
Both Central Retinal Venous Occlusion and Cilioretinal Artery Occlusion Secondary to Hyperhomocysteinemia. A Case Report
Authors:   Department of Ophthalmology, Mohammed V University, Morocco, M Aachak , H Brarou ,   Department of Ophthalmology, Mohammed V University, Morocco, I Jeddou ,   Department of Ophthalmology, Mohammed V University, Morocco, H Boui ,   Department of Ophthalmology, Mohammed V University, Morocco, T Abdellaoui ,   Department of Ophthalmology, Mohammed V University, Morocco, F El Asri ,   Department of Ophthalmology, Mohammed V University, Morocco, Y Mouzarii ,   Department of Ophthalmology, Mohammed V University, Morocco, K Reda ,   Department of Ophthalmology, Mohammed V University, Morocco, A Oubaaz ,   Department of Ophthalmology, Mohammed V University, Morocco
Published: January 2023

A 50 YO female patient with no medical history presented to the ophthalmologic emergency department for an acute decreasing of visual acuity in the left eye without any redness nor ocular pain. Ophthalmic examination revealed a best corrected VA of ‘finger counting’ in the LE. The LE slit lamp examination was normal. Fundus evaluation showed a retinal white edema in the cilioretinal artery territory associated with pre retinal hemorrhage. The foveola was spared (Figure 1).
Cataract and Celiac Disease
Authors:   Department of Ophthalmology, Hopital des spécialités, Rabat, Morocco, HE Belidi , Y Saoiabi ,   Department of Faculity Medecine, Rabat, Morocco, L Cherkaoui ,   Department of Faculity Medecine, Rabat, Morocco
Published: January 2023

24 years old patient, diagnosed 19 years ago with celiac disease, in whom we fortuitously find during a systematic ophthalmological examination in the right eye (Figure 1): a small bluish central crystalline opacification, bluish, whitish and yellowish punctiform peripheral opacifications, without any visual repercussion.
Treatment Protocol According to the Meniscal Tears: A Review the Literature for all Comparing Methods
Authors:   Department of Orthopaedic and Trauma Surgery, ASL Bari, Italy, S Bernardino
Published: January 2023

Purpose: Menisci are fibrocartilage formations that have multiple functional roles in the knee joint. After the better understanding of their function and also the observations of the changes of the knee joint after their removal, such as osteoarthritic changes, instability and changes on the allocation of the weight, a solution of repairing the tear was a demand. Methods: In our effort to conclude in one treatment protocol according to the meniscal tears we reviewed the literature for all the review articles of comparing methods of several suturing techniques of the meniscal tears. Results and Conclusions: After reviewing all these articles someone could conclude that simple sutures, mostly horizontal but also vertical have more stability and they are a good and trustable solution for the suturing of a meniscal tears. They demand then very good technique and a lot of surgical time. These very important disadvantages try to solve the various meniscal implants, but with a lower stability so far.
Modern Urban Space Formation in Cheongju-myeon in the Early Period of Japanese Colonial Era: Focusing on Land Use and Ownership
Authors:   Institute For Kyeongki Cultural Studies, Jo Jeong Kyu
Published: January 2023

This study aims to analyze how the space of the Joseon Dynasty changed into a modern urban space targeting the Cheongju-myeon area, which was reorganized in 1914. The data used for this analysis are cadastral maps and land registers written in 1912. Through this, it was analyzed how the land in Cheongju-myeon was used and how the landowner owned the land in Cheongju-myeon. In 1912, the land of Cheongju-myeon was used as a national land, rice paddies, fields, hybrid land, and sasa land. Among them, the land was used the most, and the rice paddies are distributed in the southeast of Myeon centered on Munoe-ri, and the fields are used mainly on the embankment of Musimcheon Stream in the southwest of Myeon. The land in Cheongju-myeon is owned by state-owned land, Koreans, Japanese, companies, and religious organizations. The state-owned land is mainly owned within Cheongju-eupseong Fortress, and the Japanese mainly own it inside Cheongju-eupseong Fortress and outside the south gate. The modern urban space of Cheongju-myeon is progressing in the south direction around Cheongju Eupseong Fortress, and the existing rice paddies and fields are actively used as land and roads.
The Tradition of Jiji(Chorogrphy) Compilation, its Alteration, and Efforts for Succession
Authors:   Institute For Kyeongki Cultural Studies, Kim Jong Hyuk
Published: January 2023

In this study, Jiji(Chorography) is defined in three meanings: Jiji as a geography approach, as a description format, and as a literature (classification name), and depending on the description format, Jiji is divided into Item Type Jiji and Description Type Jiji. The latter generally has both a general and a local version written in one Jiji book. This format existed in the Joseon Dynasty as in 󰡔Taekriji󰡕, but it has been established during the Japanese colonial period and continues to the present day. However, until the Japanese colonial period, the local version was more important than the general version, but after the liberation, the general version gradually became the center. However, since the general version is not different from systemic geography, the more it is emphasized, the more its color as a Jiji is bound to fade. It is no exaggeration to say that chorography, which describes the region itself rather than approaching a region as a subject, is the essence of geography. To promote Jiji, It is necessary to recognize Jiji research from a more academic point of view.
Positions and issues Approaching the Value and Utilization of Early-Modern Heritage in Korea: In Case of Incheon Army Arsenal under the Japanese Colonialism
Authors:   Institute For Kyeongki Cultural Studies, Jeon Jong Han
Published: January 2023

In general, in post-colonial countries, discord exists over the evaluation and recognition of the value of early-modern heritage, and the same is true of the Japanese Incheon Army Arsenal(JIAA) under the Japanese colonialism in Korea. The JIAA was established in 1941 as one of the 8 largest arsenals of the Japanese imperialist and one of the two arsenals built outside the mainland, which were built for the design, production, and storage of weapons during the Japanese colonial period. The JIAA was located on a vast flat area around Sangok-ri[山谷 里] with good access to Bupyeong Station of the Gyeongin Railway. The JIAA formed a large-scale munitions industrial complex with a number of companies connected in forward-and-backward linkage, and on a national scale, it was one of the modern urban zoning planned in the Bupyeong area as part of the Gyeongin Regional City Plan[京仁市街計劃]. Today, the remnants of the JIAA remain in the Bupyeong-gu area of Incheon Metropolitan City, and recently there are often conflicts with the difference in position between the central and local governments, civic groups, etc. over the value evaluation and preservation of the landscape elements of the remains of the JIAA. One of the important prerequisites to resolve this difference in position and conflict is the mobilization of concepts and theories. Since the relic landscape of the JIAA is a colonial heritage, a modern industrial heritage, and a war heritage at the same time, they should be viewed in multiple heritage categories. And on the one hand, it is necessary to recognize the various zoning and landscape elements diachronically and comprehensively from the viewpoint of the formation and evolution of the early-modern urban landscape that caused the contrast with the traditional urban landscape and the restructuring of national land space. An approach based on these concepts and theories is critical in recognition of values, orientation of utilization, and application as a world heritage. From the point of view of approaching colonial early-modern heritage, especially industrial heritage, in post-colonial countries, it is necessary to be vigilant not to simply borrow from Western countries or Japan, which were former imperialists.
A Unified Approach to (E)- and (Z)-Olefins Enabled by Low-Valent Tungsten Catalysis
Authors: Jankins Tanner , Rubel Camille , Martin-Montero Raul , Engle Keary
Published: January 2023

A positionally selective alkene isomerization in which modulation of the ligand environment of the homogeneous tungsten catalyst grants access to either the (E)- or (Z)-stereoisomer is described. Compared to previously reported alkene isomerization methods, this reaction offers exquisite chemo- and regioselectivity and is user friendly due to the use of a simple, commercial precatalyst and ligand. Preliminary mechanistic studies suggest that tungsten’s ability to adopt 7-coordinate geometry is crucial for stereoselectivity and that substrate directivity prevents over-isomerization to the conjugated alkene, as is commonly observed with other catalysts. These features allows for exclusive formation of β,γ-unsaturated carbonyl compounds that are otherwise difficult to prepare.
Selective oxidation of methane to methanol over Au/H-MOR
Authors: Wang Wangyang , Zhou Wei , Tang Yuchen , Cao Weicheng , Docherty Scott R. , Cheng Kang , Zhang Qinghong , Copéret Christophe , Wang Ye
Published: January 2023

Selective oxidation of methane to methanol by molecular oxygen is a fascinating route for upgrading abundant methane resource and represents one of the most challenging reactions in chemistry due to the overwhelmingly higher reactivity of the product versus the reactant. Here, we report that monometallic gold nanoparticles loaded on mordenite zeolite efficiently catalyze the selective oxidation of methane to methanol by molecular oxygen in the presence of carbon monoxide in aqueous medium. The methanol productivity reaches 1300 μmol gcat−1 h−1 or 280 mmol gAu-1 h-1 with 75% selectivity at 150 °C, outperforming most of those reported under comparable conditions. Both hydroxyl radicals and hydroperoxide species participate in the activation and conversion of methane; the lower affinity of methanol on gold mainly accounts for higher methanol selectivity.
Modeling molecular ensembles with gradient-domain machine learning force fields
Authors: Maldonado Alex M. , Poltavsky Igor , Vassilev-Galindo Valentin , Tkatchenko Alexandre , Keith John A.
Published: January 2023

Gradient-domain machine learning (GDML) force fields have shown excellent accuracy, data efficiency, and applicability for molecules with hundreds of atoms, but the employed global descriptor limits transferability to ensembles of molecules. Many-body expansions (MBEs) should provide a rigorous procedure for size-transferable GDML by training models on fundamental n-body interactions. We developed many-body GDML (mbGDML) force fields for water, acetonitrile, and methanol by training 1-, 2-, and 3-body models on only 1000 MP2/def2-TZVP calculations each. Our mbGDML force field includes intramolecular flexibility and intermolecular interactions, providing that the reference data properly describes these effects. We also compare this mbGDML approach to GAP, SchNet, and NequIP potentials. Energy and force predictions of clusters containing up to 20 molecules are within 0.38 kcal/mol per monomer of reference supersystem calculations. This deviation partially arises from the restriction of the mbGDML model to 3-body interactions. Given these approximations, our automated mbGDML training schemes also resulted in fair agreement with reference radial distribution functions (RDFs) of bulk solvents. These results highlight mbGDML as valuable for modeling explicitly solvated systems with quantum-mechanical accuracy.
DISINFORMATION AND FAKE NEWS: FEATURES AND METHODS OF DETECTION ON THE INTERNET
Authors: Tyshchenko Vitalii , Muzhanova Tetiana
Published: January 2023

The development of the global Internet, the large-scale introduction of fast and free online services not only expanded the possibilities of access to information, but also changed the principles of communication of society. Due to the simplification of the mechanisms for creating and disseminating news via the Internet, as well as the physical impossibility to verify huge amounts of information circulating in the network, the spread of disinformation and fake news has increased dramatically. In view of this, detecting false news is an important task that not only ensures that users are provided with verified information and prevent manipulation of public consciousness, but also helps to maintain a reliable news ecosystem.

According to the analysis of international organizations and scientific publications, disinformation is false, misleading, manipulative information created deliberately for the sake of economic, political or other benefits, and fake news is one of the methods of its dissemination. Fake news is characterized by the following features: false manipulative content; aiming to deliberately mislead, disorient the consumer; presenting information on behalf of false or anonymous sources; inconsistency with the content of the headline; use of rumors and satire; aiming to criticize social or political issues; imitation of legitimate news; dissemination on the Internet; economic or political motives of creation.

As a result of the study, it was found that Internet users, through conscious perception of information and a responsible approach to its dissemination, can reduce the effectiveness of disinformation and fake news tools. It is noted that a proven method to avoid false information is to receive news from reliable sources. However, in order to identify fake news, it is advisable to use such methods as: analysis of the source, content and headline of the news; checking information about the author and sources referred to in the message; checking the "freshness" of the news; using fact-checking tools; consulting with an expert; analyzing own emotional reaction to the news, etc.
TESTING THE ORGANIZATION'S CORPORATE NETWORK FOR UNAUTHORIZED ACCESS
Authors: Tyshyk Ivan
Published: January 2023

In today's world, the number of cyber attacks is increasing every year. These attacks lead to massive loss of confidential data, disruption of critical infrastructure. The number of cyberattacks has only increased since the beginning of the pandemic and carries with it significant financial and reputational risks for any company. The work considers possible methods of testing the security of the organization's corporate network against unauthorized penetration. Simulation of testing for unauthorized access to selected information resources was carried out and possible attacks after obtaining such access were characterized.

The most typical methods of exploitation of possible vulnerabilities in corporate networks are given. The Kali Linux distribution was chosen because it contains many tools for penetration testing, which allows for periodic testing of networks and nodes, as well as corporate network security audits in order to identify existing vulnerabilities, configuration flaws and close them before they can be used by attackers. During the study, it was found that each system is unique in its own way due to the use of different types of signatures and applications. Such a representation requires in-depth knowledge of attacks and system-specific documentation from the developer to configure the system itself to monitor specific applications. Conducted simulations of the process of detecting network attacks based on the Kali Linux OS utilities showed that this tool is a practical choice for a security administrator and allows him to detect threats to the information system in a timely manner and conduct effective monitoring of the operating environment in real time. Thanks to the utilities of the proposed system, on the basis of which a network attack on the object of protection is implemented, it is possible to eliminate a certain type of vulnerability of the information system or its constituent parts, which will make it impossible to implement many types of attacks. The directions of further research can be aimed at the development of network utilities to implement the protection of various types of operating systems against unauthorized interventions and their subsequent integration into the system of utilities for the appropriate operating environment, as well as to increase the effectiveness of monitoring the information system as a whole for the purpose of detecting various types of vulnerabilities on its assets , which will improve its protection against many types of network attacks.
DETECTION OF FAKE ACCOUNTS IN SOCIAL MEDIA
Authors: Voitovych Olesia , Leonid Kupershtein Leonid , Kupershtein Leonid , Holovenko Vitalii
Published: January 2023

Social media is becoming increasingly used as a source of information, including events during warfare. The fake accounts of the social media are often used for a variety of cyber-attacks, information-psychological operations, and social opinion manipulating during warfare. The analysis of online social media research methods are carried out, the main metrics and attributes of fake accounts in Facebook are investigated. Each metric is assigned to the appropriate categories for the convenience of their analysis and gets a certain number of points depending on conditions from 0 to 3, which indicate how much every of the metrics influenced on conclusion about the fakeness of the account. The levels of influence have the following meanings: 0 – no influence, 1 – weak influence, 2 – significant influence, 3 – critical influence. For example, if the histogram feature reaches level 3, this means that the parameter characterizing this feature has a critical impact on account fakeness. Otherwise, if the column is at 0 or 1 level, this means that the parameter is inherent in the real account. Thus, based on the level of each of the parameters, we conclude on the fakeness or reality of a certain account. The following metrics are analyzed: likes, friends, posts and statuses, personal information about the user and the photos, considering their possible parameters and influence on the status of the account. Each metric is assigned to the appropriate categories for the convenience of their analysis. A decision-making system based on a supported vector machine is developed and has 9 inputs and single output. A series of experimental research was conducted where account analyzing as well as parameters extracting and selection are realized on Facebook. The classifier accuracy of the fake accounts detection is 97% with the special prepared dataset of the real and fake account parameters.