bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis
Authors: Kim Rathana , Bergugnat Hugo , Larcher Lise , Duchmann Matthieu , Passet Marie , Gachet Stéphanie , Cuccuini Wendy , Lafage-Pochitaloff Marina , Pastoret Cédric , Grardel Nathalie , Asnafi Vahid , Schäfer Beat W. , Delabesse Eric , Itzykson Raphaël , Adès Lionel , Hicheri Yosr , Chalandon Yves , Graux Carlos , Chevallier Patrice , Hunault Mathilde , Leguay Thibaut , Huguet Françoise , Lhéritier Véronique , Dombret Hervé , Soulier Jean , Rousselot Philippe , Boissel Nicolas , Clappier Emmanuelle
Published: April 2023

Abstract
Low hypodiploidy defines a rare subtype of B-cell acute lymphoblastic leukemia (B-ALL) with a dismal outcome. To investigate the genomic basis of low-hypodiploid ALL (LH-ALL) in adults, we analyzed copy-number aberrations, loss of heterozygosity, mutations, and cytogenetics data in a prospective cohort of Philadelphia (Ph)-negative B-ALL patients (n = 591, ages 18–84 years), allowing us to identify 80 LH-ALL cases (14%). Genomic analysis was critical for evidencing low hypodiploidy in many cases missed by cytogenetics. The proportion of LH-ALL within Ph-negative B-ALL dramatically increased with age, from 3% in the youngest patients (under 40 years old) to 32% in the oldest (over 55 years old). Somatic TP53 biallelic inactivation was the hallmark of adult LH-ALL, present in virtually all cases (98%). Strikingly, we detected TP53 mutations in posttreatment remission samples in 34% of patients. Single-cell proteogenomics of diagnosis and remission bone marrow samples evidenced a preleukemic, multilineage, TP53-mutant clone, reminiscent of age-related clonal hematopoiesis.
Significance:
We show that low-hypodiploid ALL is a frequent entity within B-ALL in older adults, relying on somatic TP53 biallelic alteration. Our study unveils a link between aging and low-hypodiploid ALL, with TP53-mutant clonal hematopoiesis representing a preleukemic reservoir that can give rise to aneuploidy and B-ALL.

See related commentary by Saiki and Ogawa, p. 102.

This article is highlighted in the In This Issue feature, p. 101
Data from In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities
Authors: ten Hacken Elisa , Sewastianik Tomasz , Yin Shanye , Hoffmann Gabriela Brunsting , Gruber Michaela , Clement Kendell , Penter Livius , Redd Robert A. , Ruthen Neil , Hergalant Sébastien , Sholokhova Alanna , Fell Geoffrey , Parry Erin M. , Broséus Julien , Guieze Romain , Lucas Fabienne , Hernández-Sánchez María , Baranowski Kaitlyn , Southard Jackson , Joyal Heather , Billington Leah , Regis Fara Faye D. , Witten Elizabeth , Uduman Mohamed , Knisbacher Binyamin A. , Li Shuqiang , Lyu Haoxiang , Vaisitti Tiziana , Deaglio Silvia , Inghirami Giorgio , Feugier Pierre , Stilgenbauer Stephan , Tausch Eugen , Davids Matthew S. , Getz Gad , Livak Kenneth J. , Bozic Ivana , Neuberg Donna S. , Carrasco Ruben D. , Wu Catherine J.
Published: April 2023

Abstract
Transformation to aggressive disease histologies generates formidable clinical challenges across cancers, but biological insights remain few. We modeled the genetic heterogeneity of chronic lymphocytic leukemia (CLL) through multiplexed in vivo CRISPR-Cas9 B-cell editing of recurrent CLL loss-of-function drivers in mice and recapitulated the process of transformation from indolent CLL into large cell lymphoma [i.e., Richter syndrome (RS)]. Evolutionary trajectories of 64 mice carrying diverse combinatorial gene assortments revealed coselection of mutations in Trp53, Mga, and Chd2 and the dual impact of clonal Mga/Chd2 mutations on E2F/MYC and interferon signaling dysregulation. Comparative human and murine RS analyses demonstrated tonic PI3K signaling as a key feature of transformed disease, with constitutive activation of the AKT and S6 kinases, downmodulation of the PTEN phosphatase, and convergent activation of MYC/PI3K transcriptional programs underlying enhanced sensitivity to MYC/mTOR/PI3K inhibition. This robust experimental system presents a unique framework to study lymphoid biology and therapy.
Significance:
Mouse models reflective of the genetic complexity and heterogeneity of human tumors remain few, including those able to recapitulate transformation to aggressive disease histologies. Herein, we model CLL transformation into RS through multiplexed in vivo gene editing, providing key insight into the pathophysiology and therapeutic vulnerabilities of transformed disease.

This article is highlighted in the In This Issue feature, p. 101
Supplementary Figure 2 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T cells Administered Intravenously in Patients with Melanoma & Breast Carcinoma
Authors: Shah Payal D , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P , Brennan Andrea Lynne , Gonzalez Vanessa E , Kulikovskaya Irina , Lacey Simon F , Plesa Gabriela , June Carl H , Vonderheide Robert H , Mitchell Tara C
Published: April 2023

Supplementary Figure 2: Representative immunohistochemical staining for Subject 27 with metastatic triple-negative breast cancer; lymph node biopsy. Panel A shows CD8 staining prior to infusion and Panel B shows CD8 staining at the time of post-infusion biopsy.
Supplementary Data from Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on ADH1B and ALDH2 Genotype in Japanese Familial Adenomatous Polyposis Patients
Authors: Mure Kanae , Ishikawa Hideki , Mutoh Michihiro , Horinaka Mano , Otani Takahiro , Suzuki Sadao , Wakabayashi Keiji , Sakai Toshiyuki , Sato Yasushi , Doyama Hisashi , Tajika Masahiro , Tanaka Shinji , Horimatsu Takahiro , Takeuchi Yoji , Kashida Hiroshi , Tashiro Jun , Ezoe Yasumasa , Nakajima Takeshi , Ikematsu Hiroaki , Hori Shinichiro , Takayama Tetsuji , Ohda Yoshio
Published: April 2023

Table S1, Table S2, Table S3
Supplementary Figures 1-19, Tables 1-2 from Comprehensive Assessment of Anaplastic Lymphoma Kinase in Localized and Metastatic Prostate Cancer Reveals Targetable Alterations
Authors: Patel Radhika A. , Coleman Ilsa , Roudier Martine P. , Konnick Eric Q. , Hanratty Brian , Dumpit Ruth , Lucas Jared M. , Ang Lisa S. , Low Jin-Yih , Tretiakova Maria S. , Ha Gavin , Lee John K. , True Lawrence D. , De Marzo Angelo M. , Nelson Peter S. , Morrissey Colm , Pritchard Colin C. , Haffner Michael C.
Published: April 2023

Supplementary Figures 1-19, Tables 1-2
Supplementary Tables S1-S3 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies
Authors: Carideo Cunniff Elizabeth , Sato Yosuke , Mai Doanh , Appleman Vicky A. , Iwasaki Shinji , Kolev Vihren , Matsuda Atsushi , Shi Judy , Mochizuki Michiyo , Yoshikawa Masato , Huang Jian , Shen Luhua , Haridas Satyajeet , Shinde Vaishali , Gemski Chris , Roberts Emily R. , Ghasemi Omid , Bazzazi Hojjat , Menon Saurabh , Traore Tary , Shi Pu , Thelen Tennille D. , Conlon Joseph , Abu-Yousif Adnan O. , Arendt Christopher , Shaw Michael H. , Okaniwa Masanori
Published: April 2023

Supplementary tables: Supplementary Table 1 describes where cells were obtained from and details of authentication and mycoplasma testing dates. Supplementary Table 2 shows TAK-676 potency in cynomolgus monkey, human, mouse, and rat STING via time-resolved fluorescence resonance energy transfer assay. Supplementary Table 3 shows pharmacokinetic parameters (Cmax and AUC) after TAK-676 administration in BALB/C mice (A20 tumors).
Supplementary Methods SM1 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies
Authors: Carideo Cunniff Elizabeth , Sato Yosuke , Mai Doanh , Appleman Vicky A. , Iwasaki Shinji , Kolev Vihren , Matsuda Atsushi , Shi Judy , Mochizuki Michiyo , Yoshikawa Masato , Huang Jian , Shen Luhua , Haridas Satyajeet , Shinde Vaishali , Gemski Chris , Roberts Emily R. , Ghasemi Omid , Bazzazi Hojjat , Menon Saurabh , Traore Tary , Shi Pu , Thelen Tennille D. , Conlon Joseph , Abu-Yousif Adnan O. , Arendt Christopher , Shaw Michael H. , Okaniwa Masanori
Published: April 2023

Supplementary methods and results: The supplementary methods describe: 1) the chemical synthesis and characterization of TAK-676, inclusive of TAK-676 chemical structure, purification chromatogram and NMR characterization; 2) details regarding STING DNA cloning and purification (recombinant E. coli expression utilizing an N-terminal His tag and C-terminal Avi tag) for STING binding assays (time-resolved fluorescence resonance energy transfer assay); 3) description of pathway activation assays (inclusive of cell culture methods) in THP1-Dual™, CT26.WT, HEK293T (lack endogenous STING expression), and RAW-Lucia™ ISG cell lines; 4) methods describing the generation of STING knockout and WT cell line clones in CT26.WT and BF1610 cells via the CRISPR method; 5) details of immune cell activation assays in human dendritic cells, mouse dendritic cells, NK cells and T cells analyzed by flow cytometry; 6) details regarding inoculation of BALB/C mice with A20 cells (for generation of A20 syngeneic tumors) for pharmacokinetic analysis of TAK-676 administered intravenously; 7) details regarding inoculation of BALB/C (and Goldenticket mice with BF1610 tumor cells only) mice with CT26.WT, A20, and B16F10 tumor cells for in vivo antitumor activity analysis; 8) methods describing the in vivo pharmacodynamic effects of TAK-676 by cytokine induction and immune cell activation and proliferation. The supplementary results show that TAK-676 is tolerated in syngeneic mouse models supported by Supplementary Figure 3 (percentage body weight change in BALB/C mice [CT26.WT and A20 syngeneic tumors]) and Supplementary Figure 4 (percentage body weight change in STING-deficient Goldenticket mice [STING WT and B16F10 syngeneic tumors]).
Supplemental Figure S5 from Race-associated Molecular Changes in Gynecologic Malignancies
Authors: Asare Amma , Yao Hui , Lara Olivia D. , Wang Ying , Zhang Lin , Sood Anil K.
Published: April 2023

Analysis of differentially methylated probe locations
Figure S4 from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Authors: Hoskin Victoria , Ghaffari Abdi , Laight Brian J. , SenGupta Sandip , Madarnas Yolanda , Nicol Christopher J.B. , Elliott Bruce E. , Varma Sonal , Greer Peter A.
Published: April 2023

Assessment of microscopic metastasis and lung metastatic burden
Supplementary Table S3 from Development of an Automated Liquid Biopsy Assay for Methylated Markers in Advanced Breast Cancer
Authors: Fackler Mary Jo , Tulac Suzana , Venkatesan Neesha , Aslam Adam J. , de Guzman Timothy N. , Mercado-Rodriguez Claudia , Cope Leslie M. , Downs Bradley M. , Vali Abdul Hussain , Ding Wanjun , Lehman Jennifer , Denbow Rita , Reynolds Jeffrey , Buckley Morgan E. , Visvanathan Kala , Umbricht Christopher B. , Wolff Antonio C. , Stearns Vered , Bates Michael , Lai Edwin W. , Sukumar Saraswati
Published: April 2023

The table provides descriptive statistics and coefficient of variation for methylation in each gene in replicate LBx-BCM analyses of 300 copies of fully methylated DNA spiked into normal serum or plasma
Table S3 from A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms
Authors: Shen Qiujin , Feng Yahui , Gong Xiaowen , Jia Yujiao , Gao Qingyan , Jiao Xiaokang , Qi Saibing , Liu Xueou , Wei Hui , Huang Bingqing , Zhao Ningning , Song Xiaoqiang , Ma Yueshen , Liang Shihao , Zhang Donglei , Qin Li , Wang Ying , Qu Shiqiang , Zou Yao , Chen Yumei , Guo Ye , Yi Shuhua , An Gang , Jiao Zengtao , Zhang Song , Li Linfeng , Yan Jun , Wang Huijun , Song Zhen , Mi Yingchang , Qiu Lugui , Zhu Xiaofan , Wang Jianxiang , Xiao Zhijian , Chen Junren
Published: April 2023

Table S3. 171 sequenced genes in THAMP.
Supplemental Figure S2 from BRCA1-Associated RING Domain-1 (BARD1) Loss and GBP1 Expression Enhance Sensitivity to DNA Damage in Ewing Sarcoma
Authors: Maurer Lisa M. , Daley Jessica D. , Mukherjee Elina , Venier Rosemarie E. , Julian Claire M. , Bailey Nathanael G. , Jacobs Michelle F. , Kumar-Sinha Chandan , Raphael Haley , Periyapatna Nivitha , Weiss Kurt , Janeway Katherine A. , Mody Rajen , Lucas Peter C. , McAllister-Lucas Linda M. , Bailey Kelly M.
Published: April 2023

BARD1 loss enhances Ewing sarcoma cell apoptosis in response to niraparib plus radiation in CHLA10 Ewing sarcoma cells.
Fig S7 from World Trade Center Dust Exposure Promotes Cancer in PTEN-deficient Mouse Prostates
Authors: Wang Lin , Xu Yitian , Zhang Licheng , Kang Kyeongah , Kobryn Andriy , Portman Kensey , Gordon Ronald E , Pan Ping-Ying , Taioli Emanuela , Aaronson Stuart A , Chen Shu-Hsia , Mulholland David J
Published: April 2023

Fig. S7. Aggregate tSNE plots generated from aggregate analysis of different clusters of WTC and control patients. A, Circled populations in t-SNE plots showed significant differences between WTC and control patients. B, List of markers used to define the clusters identified in tSNE plots (WTC, n=8 and non-WTC, n=12). C, Meta clusters showing the difference in cell density values occurring in IMC tissue samplings (n=2) for each patient sample (n=10).
Fig S6 from World Trade Center Dust Exposure Promotes Cancer in PTEN-deficient Mouse Prostates
Authors: Wang Lin , Xu Yitian , Zhang Licheng , Kang Kyeongah , Kobryn Andriy , Portman Kensey , Gordon Ronald E , Pan Ping-Ying , Taioli Emanuela , Aaronson Stuart A , Chen Shu-Hsia , Mulholland David J
Published: April 2023

Fig. S6. Cell densities of different cell populations in WTC and non-WTC patient tissues samples. A, Immunoreactive cells for individual antibodies tested in WTC and non-WTC IMC analysis (WTC, n=8 patient
samples and non-WTC, n=12 patient samples). Graphs were generated based on the analysis of tSNE plots shown in Fig. S7. B, Cell numbers used for IMC analysis for non-WTC and WTC analysis
Fig S5 from World Trade Center Dust Exposure Promotes Cancer in PTEN-deficient Mouse Prostates
Authors: Wang Lin , Xu Yitian , Zhang Licheng , Kang Kyeongah , Kobryn Andriy , Portman Kensey , Gordon Ronald E , Pan Ping-Ying , Taioli Emanuela , Aaronson Stuart A , Chen Shu-Hsia , Mulholland David J
Published: April 2023

Fig. S5. Effect of WTC dust injection on prostate histology and epithelial proliferation. A, whole prostate scan showing widespread stromal and immune cell expansion. B, Low and high magnification fields showing AR positive prostate acini with increased Ki67 expression (lower mag bar = 250 μM, higher mag bar 100 μM)
Table S5-S9 from Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Authors: Silwal-Pandit Laxmi , Stålberg Stina M. , Johansson Henrik J. , Mermelekas Georgios , Lothe Inger Marie B. , Skrede Martina L. , Dalsgaard Astrid Marie , Nebdal Daniel J. H. , Helland Åslaug , Lingjærde Ole Christian , Labori Knut Jørgen , Skålhegg Bjørn S. , Lehtiö Janne , Kure Elin H.
Published: April 2023

Enriched pathways in Module M1-M5
Figures FS1-FS15 from Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Authors: Silwal-Pandit Laxmi , Stålberg Stina M. , Johansson Henrik J. , Mermelekas Georgios , Lothe Inger Marie B. , Skrede Martina L. , Dalsgaard Astrid Marie , Nebdal Daniel J. H. , Helland Åslaug , Lingjærde Ole Christian , Labori Knut Jørgen , Skålhegg Bjørn S. , Lehtiö Janne , Kure Elin H.
Published: April 2023

Supplementary figures
Supplementary Information from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women
Authors: Wang Xiaoliang , Chen Hongjie , Kapoor Pooja Middha , Su Yu-Ru , Bolla Manjeet K. , Dennis Joe , Dunning Alison M. , Lush Michael , Wang Qin , Michailidou Kyriaki , Pharoah Paul D.P. , Hopper John L. , Southey Melissa C. , Koutros Stella , Freeman Laura E. Beane , Stone Jennifer , Rennert Gad , Shibli Rana , Murphy Rachel A. , Aronson Kristan , Guénel Pascal , Truong Thérèse , Teras Lauren R. , Hodge James M. , Canzian Federico , Kaaks Rudolf , Brenner Hermann , Arndt Volker , Hoppe Reiner , Lo Wing-Yee , Behrens Sabine , Mannermaa Arto , Kosma Veli-Matti , Jung Audrey , Becher Heiko , Giles Graham G. , Haiman Christopher A. , Maskarinec Gertraud , Scott Christopher , Winham Stacey , Simard Jacques , Goldberg Mark S. , Zheng Wei , Long Jirong , Troester Melissa A. , Love Michael I. , Peng Cheng , Tamimi Rulla , Eliassen Heather , García-Closas Montserrat , Figueroa Jonine , Ahearn Thomas , Yang Rose , Evans D. Gareth , Howell Anthony , Hall Per , Czene Kamila , Wolk Alicja , Sandler Dale P. , Taylor Jack A. , Swerdlow Anthony J. , Orr Nick , Lacey James V. , Wang Sophia , Olsson Håkan , Easton Douglas F. , Milne Roger L. , Hsu Li , Kraft Peter , Chang-Claude Jenny , Lindström Sara
Published: April 2023

Funding and acknowledgements.
Figure S1 from WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe
Authors: Martin Jeffrey C. , Sims Jennie R. , Gupta Ajay , Bakin Andrei V. , Ohm Joyce Ellen
Published: April 2023

This figure includes supplementary data to show that CDC7 (DDK) inhibition delays mitotic entry in Ewing cells.
Table S4 from Bintrafusp Alfa, an Anti-PD-L1:TGFβ Trap Fusion Protein, in Patients with ctDNA-positive, Liver-limited Metastatic Colorectal Cancer
Authors: Morris Van K. , Overman Michael J. , Lam Michael , Parseghian Christine M. , Johnson Benny , Dasari Arvind , Raghav Kanwal , Kee Bryan K. , Huey Ryan , Wolff Robert A. , Shen John Paul , Li June , Zorrilla Isabel , Tzeng Ching-Wei D. , Tran Cao Hop S. , Chun Yun Shin , Newhook Timothy E. , Vauthey Nicolas , Duose Dzifa , Luthra Raja , Haymaker Cara , Kopetz Scott
Published: April 2023

Supplemental Table S4
Supplementary Data from A Spatially Resolved Mechanistic Growth Law for Cancer Drug Development Predicting Tumor Growing Fractions
Authors: Nasim Adam , Yates James , Derks Gianne , Dunlop Carina
Published: April 2023

Supplementary Calculations and Figures in one document
Supplementary Figure 4 from Remodeling of the Tumor Microenvironment Through PAK4 Inhibition Sensitizes Tumors to Immune Checkpoint Blockade
Authors: Abril-Rodriguez Gabriel , Torrejon Davis Y. , Karin Daniel , Campbell Katie M. , Medina Egmidio , Saco Justin D. , Galvez Mildred , Champhekar Ameya S. , Perez-Garcilazo Ivan , Baselga-Carretero Ignacio , Singh Jas , Comin-Anduix Begoña , Puig-Saus Cristina , Ribas Antoni
Published: April 2023

Supplementary Figure 4: PAK4 deletion does not affect MHC-I and II surface expression.
Supplementary RNA-seq Data RNA1 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy
Authors: Ngwa Verra M. , Edwards Deanna N. , Hwang Yoonha , Karno Breelyn , Wang Xiaoyong , Yan Chi , Richmond Ann , Brantley-Sieders Dana M. , Chen Jin
Published: April 2023

Excel file showing processed transcriptomics data from RNA-seq.
Supplementary Fig. S4 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy
Authors: Ngwa Verra M. , Edwards Deanna N. , Hwang Yoonha , Karno Breelyn , Wang Xiaoyong , Yan Chi , Richmond Ann , Brantley-Sieders Dana M. , Chen Jin
Published: April 2023

This figure shows Cytokines array data of whole E0771 tumor lysate and immunohistochemistry of leptin staining on GLSECKO versus WT tumor sections.
Supplementary Table 3 from Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer
Authors: Cooke Mariana , Zhang Xuyao , Zhang Suli , Eruslanov Evgeniy , Lal Priti , Daniel Reba E. , Feldman Michael D. , Abba Martin C. , Kazanietz Marcelo G.
Published: April 2023

Gene Set Enrichment analysis (GSEA) of transcription factor binding sites (TFBS).
Supplementary Fig. S1 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy
Authors: Ngwa Verra M. , Edwards Deanna N. , Hwang Yoonha , Karno Breelyn , Wang Xiaoyong , Yan Chi , Richmond Ann , Brantley-Sieders Dana M. , Chen Jin
Published: April 2023

This figure shows immunofluorescence images of increased apoptosis (Cleaved- Caspase 3) in GLSECKO tumors compared to WT while there was no significant change in proliferation (Ki-67). Quantification of these data were shown in Figure 1G and 1H.
Supplementary Data and Figures from A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination
Authors: Birtel Matthias , Voss Ralf-Holger , Reinhard Katharina , Rengstl Benjamin , Ouchan Yasmina , Michel Kristina , Hayduk Nina , Tillmann Bodo , Becker René , Suchan Martin , Theobald Matthias , Oehm Petra , Türeci Özlem , Sahin Ugur
Published: April 2023

Supplementary Data and Figures
Supplementary Figure 4 from Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer
Authors: Cooke Mariana , Zhang Xuyao , Zhang Suli , Eruslanov Evgeniy , Lal Priti , Daniel Reba E. , Feldman Michael D. , Abba Martin C. , Kazanietz Marcelo G.
Published: April 2023

Effect of PKCalpha depletion using shRNA lentiviruses on PC3 cell invasion, as determined with a Boyden chamber.
Figure S9 from The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Authors: Ingelshed Katrine , Spiegelberg Diana , Kannan Pavitra , Påvénius Linnéa , Hacheney Jessica , Jiang Long , Eisinger Silke , Lianoudaki Danai , Lama Dilraj , Castillo Francisca , Bosdotter Cecilia , Kretzschmar Warren W. , Al-Radi Omayma , Fritz Nicolas , Villablanca Eduardo J. , Karlsson Mikael C. I. , Wermeling Fredrik , Nestor Marika , Lane David P. , Sedimbi Saikiran K.
Published: April 2023

Navtemadlin treatment does not lead to bone marrow suppression.
Figure S8 from The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Authors: Ingelshed Katrine , Spiegelberg Diana , Kannan Pavitra , Påvénius Linnéa , Hacheney Jessica , Jiang Long , Eisinger Silke , Lianoudaki Danai , Lama Dilraj , Castillo Francisca , Bosdotter Cecilia , Kretzschmar Warren W. , Al-Radi Omayma , Fritz Nicolas , Villablanca Eduardo J. , Karlsson Mikael C. I. , Wermeling Fredrik , Nestor Marika , Lane David P. , Sedimbi Saikiran K.
Published: April 2023

Navtemadlin treatment does not affect tumor infiltrating lymphocytes.
Supplementary Figure 2 from Repurposing Azacitidine and Carboplatin to Prime Immune Checkpoint Blockade–resistant Melanoma for Anti-PD-L1 Rechallenge
Authors: van der Westhuizen Andre , Lyle Megan , Graves Moira C. , Zhu Xiaoqiang , Wong Jason W. H. , Cornall Kerrie , Ren Shu , Pugliese Leanna , Levy Richard , Majid Adeeb , Vilain Ricardo E. , Bowden Nikola A.
Published: April 2023

Supplementary Figure 2 shows transposable element methylation (A) and expression (B) at baseline, week 9 and week 22
Supplementary Figure 1 from Repurposing Azacitidine and Carboplatin to Prime Immune Checkpoint Blockade–resistant Melanoma for Anti-PD-L1 Rechallenge
Authors: van der Westhuizen Andre , Lyle Megan , Graves Moira C. , Zhu Xiaoqiang , Wong Jason W. H. , Cornall Kerrie , Ren Shu , Pugliese Leanna , Levy Richard , Majid Adeeb , Vilain Ricardo E. , Bowden Nikola A.
Published: April 2023

Supplementary Figure 1 shows Whole blood cell counts at baseline, week 9 and week 22
Figure S4 from The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Authors: Ingelshed Katrine , Spiegelberg Diana , Kannan Pavitra , Påvénius Linnéa , Hacheney Jessica , Jiang Long , Eisinger Silke , Lianoudaki Danai , Lama Dilraj , Castillo Francisca , Bosdotter Cecilia , Kretzschmar Warren W. , Al-Radi Omayma , Fritz Nicolas , Villablanca Eduardo J. , Karlsson Mikael C. I. , Wermeling Fredrik , Nestor Marika , Lane David P. , Sedimbi Saikiran K.
Published: April 2023

Navtemadlin treatment potentiates radiotherapy in p53+/+ B16-F10 melanoma cells.
Supplementary Figures 1-10 from Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry
Authors: White Jason A. , Kaninjing Ernest T. , Adeniji Kayode A. , Jibrin Paul , Obafunwa John O. , Ogo Chidiebere N. , Mohammed Faruk , Popoola Ademola , Fatiregun Omolara A. , Oluwole Olabode P. , Karanam Balasubramanyam , Elhussin Isra , Ambs Stefan , Tang Wei , Davis Melissa , Polak Paz , Campbell Moray J. , Brignole Kathryn R. , Rotimi Solomon O. , Dean-Colomb Windy , Odedina Folake T. , Martin Damali N. , Yates Clayton
Published: April 2023

Supplementary Figure 1. WES Analysis Workflow. Supplementary Figure 2. Variant Strand Bias. Supplementary Figure 3. Somatic Variant Filtering. Supplementary Figure 4. Manual Somatic Variant Inspection. Supplementary Figure 5. Genetic Admixture Analysis. Supplementary Figure 6. Comparison of somatic variant count based on normal sample usage. Supplementary Figure 7. TCGA EA Somatic Variant Lollipop Plots. Supplementary Figure 8. NG PCa Novel Somatic Variants. Supplementary Figure 9. Nigerian Germline Variant – Normal/Tumor Comparison Lollipop Plots. Supplementary Figure 10. TCGA PCa Somatic Variant COSMIC Signature Analysis.
Supplementary Table ST3 from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient
Authors: Valentine Henkel , Aiken William , Morrison Belinda , Zhao Ziran , Fowle Holly , Wasserman Jason S. , Thompson Elon , Chin Warren , Young Mark , Clarke Shannique , Gibbs Denise , Harrison Sharon , McLaughlin Wayne , Kwok Tim , Jin Fang , Campbell Kerry S. , Horvath Anelia , Thompson Rory , Lee Norman H. , Zhou Yan , Graña Xavier , Ragin Camille , Badal Simone
Published: April 2023

All Exonic Variants which are present in ACRJ-PC28. SIFT, Polyphen2, LRT, MutationTaster, MutationAssessor, and CADD were used to predict variant effect. Pop_Freq_max is the maximum population frequency of the variant in 1000Genome Project (Aug 2015), Exome Sequence Project (ESP6500) and Genome Aggregation Database (gnomAD). Total_Damaging represents number of times the variant was predicted as damaging by the 5 methods used. There are 605 variants that are predicted as damaging for 5 methods (green) while 296 variants are predicted as damaging for 4 out of 5 methods (orange-brown), among them is the variant in ATM (rs147934285) (dk brown). 3). Additionally, 539 variants are predicted as damaging for 3 out of 5 methods (blue-purple). The data generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Supplementary Figure S3 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Authors: Greer Yoshimi Endo , Hernandez Lidia , Fennell Emily M.J. , Kundu Manjari , Voeller Donna , Chari Raj , Gilbert Samuel F. , Gilbert Thomas S.K. , Ratnayake Shashikala , Tang Binwu , Hafner Markus , Chen Qingrong , Meerzaman Daoud , Iwanowicz Edwin , Annunziata Christina M. , Graves Lee M. , Lipkowitz Stanley
Published: April 2023

The effect of ClpP agonists on tumor initiation in vivo
Supplementary Figure S2 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Authors: Greer Yoshimi Endo , Hernandez Lidia , Fennell Emily M.J. , Kundu Manjari , Voeller Donna , Chari Raj , Gilbert Samuel F. , Gilbert Thomas S.K. , Ratnayake Shashikala , Tang Binwu , Hafner Markus , Chen Qingrong , Meerzaman Daoud , Iwanowicz Edwin , Annunziata Christina M. , Graves Lee M. , Lipkowitz Stanley
Published: April 2023

The effect of ClpP agonists on CSC function in vitro
Supplementary Table S3 from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression
Authors: Fischietti Mariafausta , Eckerdt Frank , Perez Ricardo E. , Guillen Magaña Jamie N. , Mazewski Candice , Ho Sang , Gonzalez Christopher , Streich Lukas D. , Beauchamp Elspeth M. , Heimberger Amy B. , Baran Aneta H. , Yue Feng , James C. David , Platanias Leonidas C.
Published: April 2023

Supplementary Table S3 lists proteins that were found to bind SLFN11 before or after irradiation.
Supplementary Figures S1-S3, Table S1 from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression
Authors: Fischietti Mariafausta , Eckerdt Frank , Perez Ricardo E. , Guillen Magaña Jamie N. , Mazewski Candice , Ho Sang , Gonzalez Christopher , Streich Lukas D. , Beauchamp Elspeth M. , Heimberger Amy B. , Baran Aneta H. , Yue Feng , James C. David , Platanias Leonidas C.
Published: April 2023

Fig. S1: Expression of SLFN family members after SLFN11 knockout. Fig. S2: Reduced 3-D invasion after SLFN11 knockout. Fig. S3: Expression of stem/progenitor markers after SLFN11 add-back. Table S1: Key resources table.
Supplementary Table S6 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: April 2023

Supplementary Table 6: The MD Anderson cohort 5-year survival rate and difference of 5-year restricted mean survival time in months between NSAID users and non-users by gender, race, and smoking status corresponding to Figure 2. Comparisons are made to the Georgetown cohort.
Supplementary Table S5 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: April 2023

Supplementary Table 5: The MD Anderson and Georgetown cohorts 5-year survival rates and differences of 5-year restricted mean survival time in months between NSAID users and non-users for all patients and by stage and histopathology corresponding to Figure 1. The abbreviations are AD (adenocarcinoma) and SCC (squamous cell cancer), respectively.
Supplementary Table S4 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: April 2023

Supplemental Table 4. Multicovariable analysis with variables associated with overall survival for the Georgetown cohort.
Supplementary Table S3 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: April 2023

Supplemental Table 3. Multicovariable Cox proportional hazards model with variables associated with overall survival for the MD Anderson Cancer Center cohort.
Supplementary Table S2 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival
Authors: Roszik Jason , Lee J. Jack , Wu Yi-Hung , Liu Xi , Kawakami Masanori , Kurie Jonathan M. , Belouali Anas , Boca Simina M. , Gupta Samir , Beckman Robert A. , Madhavan Subha , Dmitrovsky Ethan
Published: April 2023

Supplemental Table 2. Lung cancer patient characteristics in the MedStar-Georgetown University cohort. All lung cancers and those with adenocarcinoma (AD) or squamous cell cancer (SCC) histopathology are shown.
Supplementary Table S3 from Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis
Authors: Kwon Mijung , Rubio Genesaret , Wang Haitao , Riedlinger Gregory , Adem Asha , Zhong Hua , Slegowski Daniel , Post-Zwicker Louisa , Chidananda Anshruta , Schrump David S. , Pine Sharon R. , Libutti Steven K.
Published: April 2023

Supplementary Table S3
Supplementary Table ST5 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Authors: Murphy Ryan M. , Tasoulas Jason , Porrello Alessandro , Carper Miranda B. , Tsai Yi-Hsuan , Coffey Alisha R. , Kumar Sunil , Zeng Peter YF. , Schrank Travis P. , Midkiff Bentley R. , Cohen Stephanie , Salazar Ashley H. , Hayward Michele C. , Hayes D. Neil , Olshan Andrew , Gupta Gaorav P. , Nichols Anthony C. , Yarbrough Wendell G. , Pecot Chad V. , Amelio Antonio L.
Published: April 2023

Descriptive statistics for HNSC patients from the CHANCE study by p16 cytoplasmic/nuclear status.
Supplementary Table ST3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Authors: Murphy Ryan M. , Tasoulas Jason , Porrello Alessandro , Carper Miranda B. , Tsai Yi-Hsuan , Coffey Alisha R. , Kumar Sunil , Zeng Peter YF. , Schrank Travis P. , Midkiff Bentley R. , Cohen Stephanie , Salazar Ashley H. , Hayward Michele C. , Hayes D. Neil , Olshan Andrew , Gupta Gaorav P. , Nichols Anthony C. , Yarbrough Wendell G. , Pecot Chad V. , Amelio Antonio L.
Published: April 2023

Differentially expressed genes from the TCGA Head and Neck Squamous Cell Carcinoma (HNSC).
Supplementary Table ST1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Authors: Murphy Ryan M. , Tasoulas Jason , Porrello Alessandro , Carper Miranda B. , Tsai Yi-Hsuan , Coffey Alisha R. , Kumar Sunil , Zeng Peter YF. , Schrank Travis P. , Midkiff Bentley R. , Cohen Stephanie , Salazar Ashley H. , Hayward Michele C. , Hayes D. Neil , Olshan Andrew , Gupta Gaorav P. , Nichols Anthony C. , Yarbrough Wendell G. , Pecot Chad V. , Amelio Antonio L.
Published: April 2023

List of Primers.
Figure S7 from Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1
Authors: Kurupi Richard , Floros Konstantinos V. , Jacob Sheeba , Chawla Ayesha T. , Cai Jinyang , Hu Bin , Puchalapalli Madhavi , Coon Colin M. , Khatri Rishabh , Crowther Giovanna Stein , Egan Regina K. , Murchie Ellen , Greninger Patricia , Dalton Krista M. , Ghotra Maninderjit S. , Boikos Sosipatros A. , Koblinski Jennifer E. , Harada Hisashi , Sun Yue , Morgan Iain M. , Basu Devraj , Dozmorov Mikhail G. , Benes Cyril H. , Faber Anthony C.
Published: April 2023

RTK ligand expression in HNSCC cell lines
Figure S10 from Pharmacologic Inhibition of SHP2 Blocks Both PI3K and MEK Signaling in Low-epiregulin HNSCC via GAB1
Authors: Kurupi Richard , Floros Konstantinos V. , Jacob Sheeba , Chawla Ayesha T. , Cai Jinyang , Hu Bin , Puchalapalli Madhavi , Coon Colin M. , Khatri Rishabh , Crowther Giovanna Stein , Egan Regina K. , Murchie Ellen , Greninger Patricia , Dalton Krista M. , Ghotra Maninderjit S. , Boikos Sosipatros A. , Koblinski Jennifer E. , Harada Hisashi , Sun Yue , Morgan Iain M. , Basu Devraj , Dozmorov Mikhail G. , Benes Cyril H. , Faber Anthony C.
Published: April 2023

Effects of knockdown of Gab1 in SHP099-resistant HNSCC cell line
Figure S4 from Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
Authors: Alvarado Alvaro G. , Tessema Kaleab , Muthukrishnan Sree Deepthi , Sober Mackenzie , Kawaguchi Riki , Laks Dan R. , Bhaduri Aparna , Swarup Vivek , Nathanson David A. , Geschwind Daniel H. , Goldman Steven A. , Kornblum Harley I.
Published: April 2023

Gene lists differentially correlate with cell cycle and stemness signatures
Figure S2 from Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
Authors: Alvarado Alvaro G. , Tessema Kaleab , Muthukrishnan Sree Deepthi , Sober Mackenzie , Kawaguchi Riki , Laks Dan R. , Bhaduri Aparna , Swarup Vivek , Nathanson David A. , Geschwind Daniel H. , Goldman Steven A. , Kornblum Harley I.
Published: April 2023

Gliomasphere dataset analysis generates two clusters with clinical relevance
Supplemental Table S1 from Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer
Authors: Graf Ryon P. , Fisher Virginia , Creeden James , Schrock Alexa B. , Ross Jeffrey S. , Nimeiri Halla , Oxnard Geoffrey R. , Klempner Samuel J.
Published: April 2023

Patient demographics in the second line patient cohort.
Figure S10 from Real-world Validation of TMB and Microsatellite Instability as Predictive Biomarkers of Immune Checkpoint Inhibitor Effectiveness in Advanced Gastroesophageal Cancer
Authors: Graf Ryon P. , Fisher Virginia , Creeden James , Schrock Alexa B. , Ross Jeffrey S. , Nimeiri Halla , Oxnard Geoffrey R. , Klempner Samuel J.
Published: April 2023

Unadjusted for known treatment assignment imbalances, patients receiving 1st line ICPI vs. chemotherapy have more favorable outcomes when TMB ≥ 10 but not TMB < 10. Kaplan-Meier curves are unadjusted for imbalances (propensity weights applied). TTNT is shown by drug class for (A) TMB < 10, and (B) TMB ≥ 10. OS is shown by drug class for (C) TMB < 10, and (D) TMB ≥ 10. X-axis is truncated at 36 months. Overall survival estimates are left truncated (see Methods) with at-risk tables adjusted accordingly. Interaction models can be found in Supplemental Figure 9.
Table TS2 from Targeting Lymphoma-associated Macrophage Expansion via CSF1R/JAK Inhibition is a Therapeutic Vulnerability in Peripheral T-cell Lymphomas
Authors: Gao Xin , Kady Nermin , Wang Chenguang , Abdelrahman Suhaib , Gann Peter , Sverdlov Maria , Wolfe Ashley , Brown Noah , Reneau John , Robida Aaron M. , Murga-Zamalloa Carlos , Wilcox Ryan A.
Published: April 2023

JAK inhibitor kinase profile
Fig. S4 from Targeting Lymphoma-associated Macrophage Expansion via CSF1R/JAK Inhibition is a Therapeutic Vulnerability in Peripheral T-cell Lymphomas
Authors: Gao Xin , Kady Nermin , Wang Chenguang , Abdelrahman Suhaib , Gann Peter , Sverdlov Maria , Wolfe Ashley , Brown Noah , Reneau John , Robida Aaron M. , Murga-Zamalloa Carlos , Wilcox Ryan A.
Published: April 2023

Spontaneous apoptosis of malignant T cells ex vivo
Table TS3 from A Phase I Trial of VEGF-A Inhibition Combined with PD-L1 Blockade for Recurrent Glioblastoma
Authors: Chiu Daniel , Qi Jingjing , Thin Tin Htwe , Garcia-Barros Monica , Lee Brian , Hahn Mary , Mandeli John , Belani Puneet , Nael Kambiz , Rashidipour Omid , Ghatan Saadi , Hadjipanayis Constantinos G. , Yong Raymund L. , Germano Isabelle M. , Brody Rachel , Tsankova Nadejda M. , Gnjatic Sacha , Kim-Schulze Seunghee , Hormigo Adília
Published: April 2023

Tumor molecular characteristics
Supplementary Materials and Methods SM1 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy
Authors: Paillasse Michael R. , Esquerré Michael , Bertrand Florie A. , Poussereau-Pomié Céline , Pichery Mélanie , Visentin Virgile , Gueguen-Dorbes Geneviève , Gaujarengues Florence , Barron Pauline , Badet Gaelle , Briaux Anne , Ancey Pierre-Benoit , Sibrac David , Erdociain Eric , Özcelik Dennis , Meneyrol Jérôme , Martin Valérie , Gomez-Brouchet Anne , Selves Janik , Rochaix Philippe , Battistella Maxime , Lebbé Céleste , Delord Jean-Pierre , Dol-Gleizes Frédérique , Bono Françoise , Blanc Isabelle , Alam Antoine , Hunneyball Ian , Whittaker Mark , Fons Pierre
Published: April 2023

supplementary materials & methods
Supplementary Figure S6 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy
Authors: Paillasse Michael R. , Esquerré Michael , Bertrand Florie A. , Poussereau-Pomié Céline , Pichery Mélanie , Visentin Virgile , Gueguen-Dorbes Geneviève , Gaujarengues Florence , Barron Pauline , Badet Gaelle , Briaux Anne , Ancey Pierre-Benoit , Sibrac David , Erdociain Eric , Özcelik Dennis , Meneyrol Jérôme , Martin Valérie , Gomez-Brouchet Anne , Selves Janik , Rochaix Philippe , Battistella Maxime , Lebbé Céleste , Delord Jean-Pierre , Dol-Gleizes Frédérique , Bono Françoise , Blanc Isabelle , Alam Antoine , Hunneyball Ian , Whittaker Mark , Fons Pierre
Published: April 2023

Supplementary Figure S6 shows that EVT801 inhibits growth of VEGFR3-positive BNL hepatoma tumors, while decreasing vasculature and hypoxia
Supplementary Figure S5 from Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy
Authors: Paillasse Michael R. , Esquerré Michael , Bertrand Florie A. , Poussereau-Pomié Céline , Pichery Mélanie , Visentin Virgile , Gueguen-Dorbes Geneviève , Gaujarengues Florence , Barron Pauline , Badet Gaelle , Briaux Anne , Ancey Pierre-Benoit , Sibrac David , Erdociain Eric , Özcelik Dennis , Meneyrol Jérôme , Martin Valérie , Gomez-Brouchet Anne , Selves Janik , Rochaix Philippe , Battistella Maxime , Lebbé Céleste , Delord Jean-Pierre , Dol-Gleizes Frédérique , Bono Françoise , Blanc Isabelle , Alam Antoine , Hunneyball Ian , Whittaker Mark , Fons Pierre
Published: April 2023

Supplementary Figure S5 shows the immunohistochemical evaluation of hypoxia in NCI-H1703 subcutaneous tumor model
Figure S2 from Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies
Authors: Zhan Jingyu , Lin Dong , Watson Nathan , Esser Lothar , Tang Wai Kwan , Zhang Alex , Liu Xiufen , Hassan Raffit , Gleinich Anne , Shajahan Asif , Azadi Parastoo , Pastan Ira , Xia Di
Published: April 2023

Comparison of experimental MSLN structure with those of computational models.
Table S2 from Combination Chemotherapy of Multidrug-resistant Early-stage Colon Cancer: Determining Optimal Dose Schedules by High-performance Computer Simulation
Authors: Cockrell Chase , Axelrod David E.
Published: April 2023

The 2430 dose schedules that cured all doubly resistant mutants in 100% of 50 independent trials and allowed crypts to recover.
Supplementary Figure 6 from The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma
Authors: Taylor William , Deschamps Stéphane , Reboutier David , Paillard Luc , Méreau Agnès , Audic Yann
Published: April 2023

Conservation of TP63 splicing regulation by PTBP1 in vertebrates
Figure S3 from Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy
Authors: Zhu Zhouting , Tang Rachel , Huff Sarah , Kummetha Indrasena Reddy , Wang Lingling , Li Na , Rana Tariq M.
Published: April 2023

Supplementary Figure S3
Supplementary Figure 4 from The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma
Authors: Taylor William , Deschamps Stéphane , Reboutier David , Paillard Luc , Méreau Agnès , Audic Yann
Published: April 2023

Terminal TP63 gamma exon in tissues
Supplementary Figure S6 from The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer
Authors: Rana Priyanka S. , Wang Wei , Markovic Vesna , Szpendyk Justin , Chan Ernest Ricky , Sossey-Alaoui Khalid
Published: April 2023

Western Blot analyses of WAVE2 and ITGB1 expression in different BC cell lines, and effect of loss of WAVE2 expression on levels of ITGB1, pSRC and pFAK.
Supplementary Figure S5 from The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer
Authors: Rana Priyanka S. , Wang Wei , Markovic Vesna , Szpendyk Justin , Chan Ernest Ricky , Sossey-Alaoui Khalid
Published: April 2023

Pathway analysis of RNA-seq data generated from CTRL and WAVE2-KO MDA-MB-231 cells.
Supplementary Figure SF1 from Novel Paired Normal Prostate and Prostate Cancer Model Cell Systems Derived from African American Patients
Authors: Jung Mira , Kowalczyk Keith , Hankins Ryan , Bandi Gaurav , Kallakury Bhaskar , Carrasquilla Michael A. , Banerjee Partha P. , Grindrod Scott , Dritschilo Anatoly
Published: April 2023

Figure S1: A) Results obtained from analyses of 15 autosomal short tandem repeat (STR) loci identify the male locus amelogenin. The profile of L/P4T is unique. No mouse DNA was detected for this sample. B) Karyotype of AP4T. Of 20 metaphases counted, 5 metaphases were analyzed. 3 metaphases were then karyotyped at 425 banding resolution. The image shows the 46,XY, male karyotype. Normal karyotype (male) within the limits of resolution attained. C) Cell growth and morphology under CR condition. Non-cancerous and cancerous cells derived from AP4 were expanded using CR condition. The images of 10x and 20x are from passage 1 and stained with H&E. The bottom image shows clonogenic growth of epithelial cells and J2 fibroblasts after 4 days and 7 days of culture. On day 7, clonogenic epithelial cells are marked in yellow arrow and J2 fibroblasts in cyan blue arrow.
Supplementary Figure S3 from The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer
Authors: Rana Priyanka S. , Wang Wei , Markovic Vesna , Szpendyk Justin , Chan Ernest Ricky , Sossey-Alaoui Khalid
Published: April 2023

Hair plot of volumes of individual tumors of derived from control and WAVE2-KO MDA-231 or 4T1 BC cell lines.
Supplementary Figure S13 from The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer
Authors: Rana Priyanka S. , Wang Wei , Markovic Vesna , Szpendyk Justin , Chan Ernest Ricky , Sossey-Alaoui Khalid
Published: April 2023

Immunofluorescence analysis of the effect of loss of WAVE2 on lamellipodia formation in MDA-MB-231 cells.
Supplementary Materials and Methods, Tables and Figures SM1 from Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos
Authors: Toal Ted W. , Estrada-Florez Ana P. , Polanco-Echeverry Guadalupe M. , Sahasrabudhe Ruta M. , Lott Paul C. , Suarez-Olaya John J. , Guevara-Tique Alix A. , Rocha Sienna , Morales-Arana Alexa , Castro-Valencia Fabian , Urayama Shiro , Kirane Amanda , Wei Dongguang , Rios-Sarabia Nora , Medrano Rafael , Mantilla Alejandra , Echeverry de Polanco Magdalena , Torres Javier , Bohorquez-Lozano Mabel E. , Carvajal-Carmona Luis G.
Published: April 2023

PDF file of supplementary methods and materials, and supplementary figures and tables
Figure S5 from Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia
Authors: Kamachi Kazuharu , Ureshino Hiroshi , Watanabe Tatsuro , Yoshida-Sakai Nao , Fukuda-Kurahashi Yuki , Kawasoe Kazunori , Hoshiko Toshimi , Yamamoto Yuta , Kurahashi Yuki , Kimura Shinya
Published: April 2023

Figure S5. The combination effect of venetoclax (Ven) and S63845 (S6) in acute myeloid leukemia.
Figure S2 from Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia
Authors: Kamachi Kazuharu , Ureshino Hiroshi , Watanabe Tatsuro , Yoshida-Sakai Nao , Fukuda-Kurahashi Yuki , Kawasoe Kazunori , Hoshiko Toshimi , Yamamoto Yuta , Kurahashi Yuki , Kimura Shinya
Published: April 2023

Figure S2. 3D synergy maps of each combination treatment (OR21 plus venetoclax) in apoptosis assays.
Supplementary Figure S8 from IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines
Authors: Do-Thi Van Anh , Park Sang Min , Park Song Mi , Jeong Hye Jin , Cho Geunyoung , An Hyun-Jung , Kim Young Sang , Lee Hayyoung , Lee Jie-Oh
Published: April 2023

Gating strategy to analyze the chemotactic migration of immune cells
Supplementary Figure S6 from IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines
Authors: Do-Thi Van Anh , Park Sang Min , Park Song Mi , Jeong Hye Jin , Cho Geunyoung , An Hyun-Jung , Kim Young Sang , Lee Hayyoung , Lee Jie-Oh
Published: April 2023

Clodronate-encapsulated liposomes show cytotoxicity to BMDMs but not to B16F10 cells