bluuebunny/crossref_metadata_2025 huggingface dataset:
Gain of function NOTCH3 variants cause familial partial lipodystrophy due to activation of senescence pathways
Authors: Garg Abhimanyu , Xing Chao , K. Agarwal Anil , K. Westfall Aundrea , R. Tomchick Diana , Zhang Xunzhi , Xing Michelle , J. Brown Rebecca
Published: December 2024

Despite elucidation of the molecular genetic basis of several lipodystrophy syndromes, molecular defects in some ultra-rare subtypes of familial lipodystrophies remain unidentified. We analyzed whole exome sequencing (WES) data of four affected and two unaffected females from an undiagnosed autosomal dominant familial partial lipodystrophy (FPL) pedigree and identified only one novel heterozygous variant, p.Ala1603Tyr in NOTCH3 meeting the filtering criteria. Further analysis of WES data of 222 unexplained FPL patients identified two unrelated FPL patients with novel heterozygous, p.Cys1600Tyr and p.Gln1552Pro, NOTCH3 variants. All variants were clustered in the heterodimerization domain of the negative regulatory region of NOTCH3. RNA-Seq and proteomics analysis of skin fibroblasts revealed significantly higher RNA and protein expression of NOTCH3 and activation of widespread senescence pathways in the FPL patients versus controls. NOTCH3 is highly expressed in adipose tissue and plays many crucial roles in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. We conclude that gain-of-function missense variants in the negative regulatory region of NOTCH3 cause a novel subtype of FPL by activation of senescence pathways. This novel variety of FPL should be considered for non-obese patients with early- or childhood-onset diabetes mellitus.
Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation
Authors: Wang Yujing , Huang Wenjie , Jia Haidong , Tang Qinglian , Yin Qingfei , Chen Yuanyuan , Wang Wumei , Cao Zhengyu
Published: December 2024

Epidermal growth factor receptors (EGFRs) regulate the growth and repair process of epithelia, as well as carcinogenesis. Activation of TRPV3 by carvacrol stimulates skin inflammation and epidermal hyperplasia; the latter can be suppressed by EGFR inhibition. However, whether EGFR signalling is responsible for skin inflammation remains elusive. The current study investigated the effect of erlotinib, an EGFR inhibitor, on skin inflammation in a carvacrol-induced atopic dermatitis mouse model. It was observed that erlotinib significantly attenuated carvacrol-induced overexpression of proinflammatory cytokines and suppressed peripheral blood mononuclear cell recruitment in HaCaT keratinocytes. In addition, it was demonstrated that erlotinib suppressed carvacrol-induced Akt and NF-κB signalling pathways. Furthermore, inhibition of Akt and NF-κB signalling pathways also attenuated the carvacrol-induced keratinocyte proinflammatory response. Finally, it was demonstrated that erlotinib treatment alleviated carvacrol-induced dermatitis. These data demonstrate that erlotinib ameliorates skin inflammation by regulating Akt and NF-κB-mediated keratinocyte proinflammation, suggesting the therapeutic potential of erlotinib, a clinically used EGFR inhibitor, in skin inflammatory diseases.
Social Inequalities and Care for Older Adults: An Ethical Perspective
Authors: TMJ Verdecia , PE Escalona , LLA Gomez
Published: December 2024

Over the last four decades, the interest in investigating social inequalities has been striking; this issue has become one of the
most important challenges facing humanity today. This article examines the intersections between social inequalities and care
for older adults from an ethical perspective. Through a multidimensional analysis, aspects such as health, access to services,
social inclusion and the impact of public policies on this relationship are addressed. The particularities observed today are
discussed, as well as their expressions in family and community interactions, and recommendations are made to improve the care and comprehensive management of this relationship based on certain pertinent ethical principles.
MAIN HISTORICAL PERIODS OF FORMATION AND THEIR INFLUENCE ON THE MODERN DEVELOPMENT
OF OPEN PUBLIC SPACES IN CITIES
Authors:   Kyiv National University of
            Construction and Architecture, Husiev Mykyta
Published: December 2024

With the emergence of the first settlements, people needed areas that would serve
as a place for social activities. The gradual growth of these settlements led to an
increase in the importance of these areas, with specialized areas for cultural buildings
or trade. Over time, the urban structure became more complex, but streets and squares
always remained the main formative elements. Technological development made changes in
the development of cities and contrasted new concepts with the traditions of the past,
subordinating design activities to the needs of modern transportation, technical,
environmental and economic feasibility. Over a long period of time, the open public
space of cities and its understanding have been changing in the perception of
architects, and indeed the people for whom these spaces are intended. The worldview,
functions, and interrelationships of individual components of the architectural
environment have been transformed, and the understanding of the goals of space has also
changed, which means that we should strive for such spaces. The article reviews,
summarizes and systematizes the main historical periods of formation and their impact on
the modern development of open public spaces in cities. The common features and
characteristic features of the formation of open public spaces in cities at each of the
main historical stages are identified. The importance of taking into account the
relationship between human social needs and physical space is shown. The relationship
between the formation of public spaces in Ukrainian cities and the main historical
stages is presented. The analysis of the main historical periods made it possible to
trace the attitude of people to the open public space of cities at different times, as
well as to identify common and distinctive features, constant features and elements. It
was found that the need for open public spaces was present at all historical stages, but
their functional content changed. It can be traced that European architecture, the only
difference is that the development of urban planning in Ukraine, similar to the European
periods, occurred with a certain delay.
DEVELOPMENT AND CLASSIFICATION OF DYNAMIC ARCHITECTURE
Authors:   Department of architectural
            design, Lviv Polytechnic National University, Kashuba Oksana , Yakubovsky Viacheslav ,   Department of architectural
            design;, Lviv Polytechnic National University, Polikrovskyi Olexsandr ,   Department of architectural
            design Lviv Polytechnic National University
Published: December 2024

This article presents a historical overview of the development of kinetic
architecture starting from the 20th century. - the first attempts to implement the
futuristic ideas of Thomas Hein, Angelo Invernitz, Buckminster Fuller Jon Friedman,
Cedric Price. Two main reasons for the appearance of kinetic architecture are argued.
This is the creation of a new architectural environment as a response to changes in the
paradigm of world perception - a dynamic and adaptive to new needs environment using the
latest computerized and mechanized systems and devices. The main theses and stages of
the formation of kinetic architecture of the 1950s and 1960s are derived. In the
article, examples of implemented objects are considered through the prism of the
author's variant of dynamic architecture classification. The study proposes a new
classification structure, the criteria of which are - methods of creating dynamics (true
movement of parts of objects and visual illusion of movement); the size of moving
elements (large and small elements), the function of dynamic elements (ensuring the
optimal indoor microclimate, protection against adverse weather conditions,
interactivity, ensuring energy efficiency, transformation of spaces) by the type of
element transformation. The proposed classification system is an attempt to systematize
the approach to understanding, development of dynamic architecture and its areas of
application. The authors highlight the advantages and disadvantages of kinetic
architecture. The advantages include: adaptability and flexibility of internal spaces,
improvement of energy efficiency of buildings, improvement of interaction with a
specific user, aesthetic appeal. Disadvantages include increased complexity of both
design and construction, resulting in higher initial costs, additional maintenance costs
and potential failures, limited adaptability to traditional architectural environments.
Kinetic architecture (alternative term - dynamic) is a new direction that changes the
approach to design and requires the involvement of specialists from various fields, and
depends on new digital technologies, materials, the ability to integrate renewable
sources into architecture. This is a very progressive direction, which sets before
itself not only architectural and visual tasks, but also a complex of global problems of
humanity to be solved.
ORGANIZATIONAL STRUCTURE AND LEGISLATION ACTIVITIES ON THE PROTECTION OF MONUMENTS
IN EASTERN HALICHINA DURING THE AUSTRIAN-HUNGARIAN PERIOD
Authors:   Department of Design and
            Fundamentals of Architecture, Lviv Polytechnic National University, Linda Svitlana
Published: December 2024

The article examines the stages of formation of the organizational structure and
legislative foundations of monument protection activities in Eastern Galicia during the
Austro-Hungarian period against the background of national processes. It is shown that
the formation of the organizational structure in Eastern Galicia took place
synchronously with the processes in Vienna and was controlled from the center. However,
the peculiarity was that at the end of the 19th century. in Eastern Galicia (as well as
in Western) non-governmental organizations of conservators are being formed, which
actually control all local monument protection processes. It is also shown that the
activities of conservation organizations focused on management issues, as well as on the
problems of inventory, cataloging of architectural monuments, and publishing activities.
The problems of the theory of conservators' activities, the methods of conservation
and restoration works were not reflected in the documents and the activities of monument
protection organizations. It was noted that the representation of the activity of the
conservatives of Eastern Galicia at the national level was not significant.
EVOLUTION OF RAPID CONSTRUCTION METHODS
Authors:   Department of Architectural
            Environment Design, Lviv Polytechnic National University, Nahirniak Volodymyr-Maksym , Ivanov-Kosteckyy Serhii ,   Department of Architectural
            Environment Design, Lviv Polytechnic National University
Published: December 2024

The article examines the evolution of rapid construction methods, starting from
traditional techniques and ending with modern innovative technologies. Today, most
people prefer houses built in the traditional way; however, this trend is changing due
to the growing popularity of prefabricated constructions. This is driven by the economic
efficiency and speed of erecting such buildings. The study includes an analysis of
literary sources and practical visits to construction sites, providing a detailed
understanding of how modern technologies are transforming the construction industry.
Special attention is given to traditional materials such as wood, stone, and clay, and
their transformation into modern methods, including precast concrete, prefabricated
wooden panels, and 3D printing. The analysis of recent studies shows that new
construction methods based on traditional techniques significantly reduce construction
time and costs, while also improving quality and environmental sustainability. The
article also reviews the works of leading researchers in this field, such as Khan and
Khan (2019), who emphasize the efficiency of modern construction methods, and Vatan
(2017), who explores the cultural aspects of traditional building systems and their
impact on modern technologies. Hagman examines the method of cordwood construction,
highlighting its historical importance and adaptation to modern conditions. Based on the
research conducted, the authors conclude that the evolution of rapid construction
methods has a significant impact on modern architecture, ensuring the fulfillment of
contemporary construction requirements, reducing costs, and minimizing environmental
impact. The evolution of construction methods reflects a dynamic and progressive path
from the meticulous craftsmanship of the past to the high-tech innovations of
today.
THE PROSPECT OF USING 3D PRINTING TECHNOLOGY FOR THE CONSTRUCTION OF RESIDENTIAL
BUILDINGS IN UKRAINE
Authors:   Department of Architectural
            Environment Design, Institute of IARD, Lviv Polytechnic National
            University, Pyndzyn Marian , Ivanov-Kostetskyi Serhii ,   Department of Architectural
            Environment Design, Lviv Polytechnic National University
Published: December 2024

The article highlights the prospects of using 3D printing technology for the
construction of residential buildings in Ukraine. The origin and initial use of 3D
printing technology in the construction industry took place in the 80s of the last
centuries. The first house project was implemented using 3D printing in 2014. The author
cites data from Grand View Research showing a significant growth in the global 3D
printing market, which is due to active research and development of three-dimensional
printing and growing demand in the world. The article provides examples of global
experience in the implementation of houses using 3D printing, namely the habitat for
sustainable living by the Italian company WASP© 3D Natives under the TECLA project. The
advantage of this project is the integration of local resources for the implementation
of the object. This approach is environmentally friendly and speeds up the construction
process. The article also describes and analyses the C3PO project by Kamp C. The house
was 3D printed by the German COBOD BOD2 printer. The article highlights a number of
features and advantages of the COBOD BOD2 printer. The article presents the Dutch
experience of 3D printing a building. The project of a house in Eindhoven is called
Milestone. The advantage of this example of building a house with a 3D printer is the
ability to print the entire building without the need for secondary structures and the
cost-effectiveness of the exterior and interior of the building. The article discusses
the largest 3D printed building in Dubai. This version used local materials and
efficient insulation to reduce energy consumption. The building was printed in extreme
conditions. The scale of the building makes it possible to quickly address mass needs.
Based on the material covered, the author summarizes the positive experience and
successful integration of 3D printing technology in the construction of residential
buildings, highlights a number of advantages and disadvantages of this technology and
the prospects for its use in Ukraine
ARCHITECTURE OF MILITARY MEMORIAL. THE EXPERIENCE OF THEIR DESIGN IN UKRAINE AND IN
THE WORLD
Authors:   Department of Architectural
            Environment Design Lviv Polytechnic National University, Proskuriakov Viktor , Baryliak Yurii ,   Department of Architectural
            Environment Design Lviv Polytechnic National University
Published: December 2024

The article provides a comprehensive analysis of the historical prerequisites for
the formation of memorial architecture and modern trends in the design of memorial
objects, in particular military cemeteries, which reflect the memory of historical
events and fallen heroes. Special attention is paid to the experience of creating such
objects in Ukraine and abroad, covering memorial complexes in Kyiv, Odesa, Cherkasy and
Lviv, as well as in Serbia, Croatia, Bosnia and Herzegovina, Germany and the USA. The
study covers architectural and artistic-aesthetic solutions of memorial complexes, which
embody not only historical memory, but also function as symbols of national identity and
cultural identity. Particular emphasis is placed on modern approaches, dominated by
minimalist and supremacist solutions, which create an emotional and spiritual atmosphere
for visitors, helping not only to honor the memory of the fallen, but also to gain a
deeper understanding of one's own national belonging. The authors analyze the
examples of design of memorial objects developed by the Lviv School of Architecture, in
particular, the Department of Architectural Environment Design, in the form of
educational, research and competition projects. These projects have the potential for
the further development of the national architecture of memorial-monumental design, in
particular in the context of commemorating the fallen military and civilians in
Ukraine's current war against Russian aggression. Examples of the renovation of
memorial objects, developed within the framework of bachelor's and master's
programs, were studied, in particular, projects of military memorials in Lviv and other
cities of Ukraine. Emphasis is placed on the combination of architectural, cultural and
national aspects in the creation of memorial objects that serve not only as places of
memory, but also as symbols of national unity and identity. This work emphasizes the
importance of an architectural approach to the preservation of historical memory,
contributing to the formation of new cultural symbols and the revival of national
heritage through monumental and memorial design.
LANDSCAPE ARCHITECTURE AS A TOOL FOR HARMONIZING HUMAN AND NATURE
Authors:   4th year student of the
            Department of Archіtecture and Conservation , Lviv Polytechnic National University,
            Lviv, Rosliakov Mykhailo , Volianiuk Valeriia ,   6th year student of the
            Department of Archіtecture and Conservation , Lviv Polytechnic National University,
            Lviv, Pohranychna Iryna ,   Ph.D. in Architecture,
            Associate Professor of the Architecture and Conservation Department, Lviv Polytechnic
            National University, Lviv
Published: December 2024

Landscape architecture is a complex concept that includes the spatial organization
of territory, the combination of natural, building, and architectural components into a
unified composition that carries aesthetic significance and a certain artistic image. It
is a field of architecture and a comprehensive form of art that studies the composition
of the environment, the principles of organizing landscapes in urban and suburban areas.
One of the main tasks of landscape architecture is to provide a territory with an
artistic appearance using landscape components, especially plants, natural materials,
relief, and climate. The article explores the role of landscape architecture in creating
harmonious relationships between humans and the surrounding nature, as well as the
importance of conserving natural resources. It presents examples of projects where
landscape architecture contributes to improving ecological conditions and quality of
life, examines the role of landscape architects, and discusses the potential use of
modern technologies. The practical significance of the research lies in the fact that,
based on theoretical knowledge and key approaches to the ecological, biological, and
decorative properties of woody plants, specialists will be able to: – Professionally
select assortments for landscape architecture projects in urbanized and industrial
areas; – Develop recommendations for creating sustainable plant communities in urban
environments, considering the fundamental principles of selecting woody plants; –
Quality develop project documentation for various landscape architecture objects:
situational, master, dendrological, general plans, layout, and planting drawings; –
Compose various landscape compositions using vegetation, water features, landforms,
small architectural forms, decorative coverings, and more.
THE EVOLUTION OF APPROACHES TO THE PRESERVATION OF ARCHAEOLOGICAL RELICS OF
ARCHITECTE: A REVIEW OF INTERNATIONAL DOCUMENTS
Authors:   postgraduate student of
            Arhitecture and Conservation Department Lviv Polytechnic National University,
            Lviv, Serbin Anna
Published: December 2024

Archaeological sites are non-renewable resources of global significance,
containing material evidence of the past. International documents and charters have
played a crucial role in shaping the principles of archaeological heritage preservation.
This study examines the theoretical foundations of archaeological site conservation as
outlined in international documents and charters from the 20th and 21st centuries, which
contribute to the evolving ethics of interventions in archaeological sites. Special
attention is given to analyzing the legal status of ratified international documents in
Ukraine, emphasizing the importance of ratifying those documents that have yet to be
adopted at the national level. The problem of archaeological preservation becomes
increasingly relevant as new architectural heritage objects are discovered annually.
Many of these architectural relics lack primary protective measures, such as roofs or
other structures, rendering them vulnerable to deterioration due to environmental
factors, improper use, negligence, or misguided interventions. In the absence of
appropriate protection, these objects are particularly susceptible to degradation,
underscoring the need for urgent preservation measures. Nowadays, cultural heritage
faces numerous threats, such as climate change, urbanization, and wars. For Ukraine, it
is essential not only to acknowledge the significance of presenting archaeological
sites, which embody the identity and values of society, but also to actively implement
international preservation standards. This study also highlights the need for
comprehensive research into international documents and charters, based on centuries of
experience in preservation of archaeological remains of architecture, achieved through
trial and error. Ukraine must integrate global experiences into national practices to
avoid past mistakes and ensure the reliable preservation of archaeological heritage for
future generations. The article's objective is to analyze approaches to the
preservation of architectural archaeological relics based on international documents and
charters, exploring the evolution of these approaches and the values of heritage they
delineate. The research aims to shed light on the problem of insufficient implementation
of international norms into national legislation and restoration practices.
Analisis Reduplikasi pada Puisi Liburan Sekolah Karya Joko Pinurbo
Authors:   Program Studi Magister Linguistik, Fakultas Ilmu Budaya, Universitas Sumatera Utara, Parasian Nehemia Anugrah , Rizal Billy Affandie ,   Program Studi Magister Linguistik, Fakultas Ilmu Budaya, Universitas Sumatera Utara, Nasution Khairina ,   Program Studi Magister Linguistik, Fakultas Ilmu Budaya, Universitas Sumatera Utara, Deliana Deliana ,   Program Studi Magister Linguistik, Fakultas Ilmu Budaya, Universitas Sumatera Utara, Widayati Dwi ,   Program Studi Magister Linguistik, Fakultas Ilmu Budaya, Universitas Sumatera Utara
Published: December 2024

Reduplication is the process of repeating a grammatical form, either fully or partially, whether with phoneme variation or not. The purpose of this research is to describe the forms of reduplication found in the poem School Vacation by Joko Pinurbo. The method used in this research is descriptive qualitative with data collection techniques (1) collecting data; (2) selecting data; and (3) categorizing data. The data analysis method in this research is as follows: data reduction, data presentation, and conclusion and verification. The results show that there are four types of reduplication in the poem Liburan Sekolah by Joko Pinurbo, including: (1) full reduplication, such as jalan-jalan, pelan-pelan, henti-henti, malam-malam, remang-remang, ketawa-ketawa, kepingan-kepingan, cari-cari, duduk-duduk, kata-kata, diam-diam, buku-buku, lelaki; (2) partial reduplication, such as berangsur-angsur, memecah-mecah, kenang-kenangan, melihat-lihat, membuka-buka, berdenyit-denyit, dibuat-buat, dikoyak-koyak; (3) reduplication of affixation, namely disipit-sipitkan; and (4) reduplication of phoneme change, namely seluk-beluk.

Keywords: linguistic analysis, reduplication, morphology, poetry, joko pinurbo
Raiskaus sodan ympäristötuhon paralleelina Hanneriina Moisseisen moniaistisessa sarjakuvateoksessa Kannas
Authors: Colliander Alex
Published: December 2024

Artikkelissa tarkastellaan kuvataiteilija Hanneriina Moisseisen moniaistisessa teoskokonaisuudessa Kannas (2016) rakentuvaa äänellistä ja kuvallista tulkintaa sodankäynnin ympäristövaikutuksista. Käsittelyn keskiöön nostetaan teoksessa äänellisesti ja visuaalisesti kuvattu seksuaalisen väkivallan teko, jota itämerensuomalaisen huolirunon kontekstissa tarkastellaan paralleelisessa suhteessa sodan aiheuttamaan ympäristötuhoon.Artikkelin käsittelyn perusteella Kannas-teoskokonaisuus määritellään ympäristötekstiksi, joka osallistuu nykyhetkessä käytävään ympäristökriittiseen keskusteluun ja jota voidaan käyttää esimerkkinä suomalaisesta ekokansanmusiikista; ihmisen ja ympäristön välisiä suhteita ja niihin vaikuttavia kulttuurisia ilmiöitä kriittisesti nykyhetkessä tarkastelevasta suomalaisesta nykykansanmusiikista, joka käyttää ympäristökriittisesti orientoituneen ilmaisunsa rakennusaineena itämerensuomalaiseen kansanomaiseen kulttuuriperintöön sisältyvää musiikillista tai muuta kulttuurista ainesta.
Artikkelin teemakuva: Terenttilän "metsää" sodan jäljiltä. Taipale 2.9.1941. Kuva: SA-kuva.
Musiikkipoliittisesta vaikuttamisesta tutkijaverkostojen ylläpitämiseen
Authors: Seye Elina , Öhman Nina C.
Published: December 2024

Artikkelissa luodaan katsaus tänä vuonna 50. toimintavuottaan juhlivan Suomen etnomusikologisen seuran kehitykseen sen perustamisesta tähän päivään. Esittelemme seuran moninaisia toimintamuotoja sekä sitä, millaisia muutoksia niissä on tapahtunut seuran toiminnan aikana. Jos seuran varhaisia toimintavuosia leimasi ”kulttuuriaktiivisuus” ja vahva pyrkimys yhteiskunnalliseen vaikuttamiseen, tänä päivänä toiminnassa painottuu ennemminkin tutkijoiden välisten yhteyksien edistäminen ja ylläpitäminen. Katsaus pohjautuu seuran arkistoihin (pöytäkirjat, toimintasuunnitelmat ja toimintakertomukset) ja julkaisuihin sekä seuran toimintaa ja suomalaista etnomusikologiaa käsitteleviin kirjoituksiin. 
Artikkelin teemakuva: Rekisteröitymistä ja iloisia jälleennäkemisiä seuran järjestämän ICTMD Nordic-Baltic Network Conference -tapahtuman vastaanottotiskillä lokakuussa 2024.
Shibuyaan palautettu ”Shibuya-kei”-musiikki
Authors: Katō Ken
Published: December 2024

Japanissa 1990-luvulla syntyneen, ”Shibuya-kei”-nimellä tunnetun musiikkityylin kategorisointia on pidetty epätäsmällisenä, koska muusikoiden ja muiden asianosaisten näkökulmasta kyseessä oli ulkopuolelta annettu markkinointitermi. Musiikintekijät välttelivät siksi kappaleidensa yksioikoista yhdistämistä Shibuyaan sijaintina, eikä ”Shibuya-keiksi” luokitellun musiikin sanoituksissa esimerkiksi viitattu Shibuyan imagoon. Globalisaatiokehityksen myötä tapahtuneen kaupunkien uudelleenrakentamisen ja turismin kiihtymisen yhteydessä Shibuya-kei on kuitenkin alettu tulkita uudelleen Shibuyan kaupunkitilassa vaalituksi musiikkikulttuuriksi. Tässä artikkelissa valaistaan näiden tulkintasuhteiden keskinäistä vaikutusprosessia keskittymällä paikallisuuteen populaarimusiikissa.
Artikkelin teemakuva: Shibuya-musiikkia länsimaisille kuulijoille esittelevän Sushi 3003 -kokoelma-albumin kansi (Bungalow, 1996).
Performatiivista viestintää
Authors: Al-Ghabra Haneen Shafeeq
Published: December 2024

Tutkimus käsittelee performatiivista palestiinalaisen vastarinnan hiphop-musiikin kautta tapahtuvaa viestintää keskittyen rodun, luokan, sosiaalisen sukupuolen ja seksuaalisuuden risteyskohtiin sekä kulttuuristen esityspaikkojen teoretisointiin (theorizing cultural sites of performance). Kirjoittaja esittelee neljä vastarinnan osa-aluetta palestiinalaisessa hiphop-musiikissa yhdistäen ne samalla omaan esittäjän ääneensä. Tavoitteena on luoda palestiinalaisten kanssa globaalia yhteyttä ja vuorovaikutusta performanssin kautta – elivätpä he sitten diasporassa tai Palestiinassa – sekä käsitellä samalla suurempia vallitsevia rakenteita.
Artikkelin teemakuva: Shadia Mansour ja M1 kappaleen "Al-Kufiyyeh 3Arabeyyeh" videolla. Kuvakaappaus YouTubesta.
Sinergicheskaya effektivnost' nizkointensivnoj ekstrakorporal'noj udarno-volnovoj terapii i obogashchennoj trombocitami plazmy pri erektil'noj disfunkcii
Authors: Ли Й. Ч. , Янг Т. Д. , Чен У. Ч. , Дуби Н. К. , Чатурведи Х. , Хуанг А. Ч. , Чанг Ч. Х. , Лин Ц. Ц. , Лю М. Ч.
Published: December 2024

Erektil'naya disfunkciya (ED) — patologicheskoe sostoyanie reproduktivnoj sistemy, pri kotorom narushaetsya sposobnost' dostizheniya ili podderzhaniya erekcii. Ono gubitel'no skazyvaetsya na vzaimootnosheniyah, uverennosti v sebe i effektivnosti. Metod lecheniya ED — nizkointensivnaya udarno-volnovaya terapiya (nizkointensivnaya UVT). Odnako ee primenenie svyazano s nezhelatel'nymi yavleniyami, takimi kak sinyaki, pokrasneniya i bol'. V hode nastoyashchego issledovaniya primenyali obogashchennuyu trombocitami plazmu (PRP) — poluchennyj iz krovi biomaterial, soderzhashchij bol'shoe kolichestvo faktorov rosta, dlya povysheniya terapevticheskoj effektivnosti nizkointensivnoj UVT pri ED. Ocenivali sinergicheskij effekt PRP i nizkointensivnoj UVT, pri etom nizkointensivnuyu UVT primenyali ekstrakorporal'no odnovremenno s PRP. Ocenku klinicheskih pokazatelej provodili cherez 22 ± 2, 50 ± 2 i 78 ± 2 dnej. Statisticheskij analiz vypolnyali s pomoshch'yu neparametricheskogo kriteriya Fridmana dlya povtornyh izmerenij (al'ternativa dispersionnomu analizu (ANOVA)). Fiksirovali pokazateli Mezhdunarodnogo indeksa erektil'noj funkcii (MIEF-5) i pokazateli tverdosti polovogo chlena pri erekcii (EHS). Pokazatel' po shkale MIEF-5 do lecheniya sostavil 8,36 ± 1,44 ballov. CHerez 22 ± 2 dnya kombinirovannogo lecheniya s primeneniem PRP i nizkointensivnoj UVT pokazatel' sostavil 14,45 ± 2,12 ballov (p < 0,028), a v dal'nejshem uvelichilsya do 15,45 ± 1,93 (p < 0,008) i 16,18 ± 1,48 (p < 0,001) ballov — cherez 50 ± 2 i 78 ± 2 dnej lecheniya sootvetstvenno. Srednij pokazatel' po shkale EHS do lecheniya sostavil 1,64 ± 0,20 (p < 0,002). On uvelichilsya do 2,81 ± 0,26 (p < 0,002), 3,09 ± 0,25 (p < 0,0002) i 3,18 ± 0,12 (p < 0,000) cherez 22 ± 2, 50 ± 2 i 78 ± 2 dnej sootvetstvenno. Kombinirovannoe lechenie s primeneniem PRP i nizkointensivnoj UVT prodemonstrirovalo moshchnyj sinergicheskij effekt, uluchshiv pokazateli MIEF-5 i EHS. Odnako dlya dostizheniya konsensusa neobhodimy shirokomasshtabnye klinicheskie issledovaniya mekhanizmov etogo yavleniya.
С чего начинается физика?
Authors: Джомирзоев Субхон
Published: December 2024

В первом параграфе показана неполность предложенных де Бройлем формул корпускулярно-волнового дуализма (КВД) нерелятивиствкого электрона (НЭ) . Во втором параграфе показана полная форма формул КВД НЭ , так же , указана , как корпускулярные и волновые величины выводятся из более общих величин .
Наставничество в постдипломном сопровождении педагогов дополнительного образования
Authors: Горюшина Екатерина
Published: December 2024

В статье рассматриваются особенности организации наставничества как формы постдипломного сопровождения педагогов дополнительного образования. Автор приводит результаты исследования о целесообразности и специфике наставнической деятельности
HUBUNGAN TINGKAT PENGETAHUAN TERHADAP PERILAKU SWAMEDIKASI BATUK MASYARAKAT KELURAHAN SERUA TANGERANG SELATAN
Authors: Teodhora  , Ainun Wulandari  , Kinanthi Kusumawardhani
Published: December 2024

Abstract—Self-medication is a way for someone to heal themselves in dealing with complaints such as illness or disease symptoms without using a doctor's prescription. One of the diseases that can be treated with self-medication is cough. This study aims to determine the relationship between knowledge and cough self-medication behavior in the community of RW 23, Serua Village, Ciputat District, South Tangerang City. This research is descriptive-analytical research with a cross-sectional design; research data was taken using a questionnaire. The number of respondents was 255. The sampling technique used Cluster Random Sampling. The research results obtained variable levels of knowledge in the excellent category (60.4%), sufficient category (22.0%), and poor category (17.6%). Behavioral variables in the excellent category (64.3%), sufficient category (18.4%), and poor category (17.3%). There is a relationship between education and income on knowledge of cough self-medication with a p-value of 0.000 < 0.05, so H0 is rejected and H1 is accepted. There is a relationship between the level of knowledge and cough self-medication behavior of the community in RW 23, Serua Village, Ciputat District, South Tangerang City, with a p-value of 0.000 < 0.05, so H0 is rejected, and H1 is accepted. 
Keywords: cough, behavior, knowledge, self-medication
 
Abstrak—Swamedikasi adalah cara seseorang menyembuhkan diri dalam menangani keluhan seperti penyakit ataupun gejala – gejala penyakit tanpa menggunakan resep dokter. Salah satu penyakit yang dapat dilakukan dengan swamedikasi adalah batuk. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan dan perilaku swamedikasi batuk pada masyarakat RW 23 Kelurahan Serua Kecamatan Ciputat Kota Tangerang Selatan. Penelitian ini merupakan jenis penelitian deskriptif analitik dengan rancangan cross sectional; data penelitian diambil menggunakan kuesioner. Jumlah responden sebanyak 255. Teknik pengambilan sampel menggunakan Cluster Random Sampling. Hasil penelitian diperoleh variabel tingkat pengetahuan dengan kategori baik (60,4%), kategori cukup (22,0%), dan kategori kurang (17,6%). Variabel perilaku dengan kategori baik (64,3%), kategori cukup (18,4%) dan kategori kurang (17,3%). Ada hubungan antara pendidikan dan pendapatan terhadap pengetahuan swamedikasi batuk dengan p-value sebesar 0,000 < 0,05, maka H0 ditolak dan H1 diterima. Ada hubungan antara tingkat pengetahuan terhadap perilaku swamedikasi batuk masyarakat di Wilayah RW 23 Kelurahan Serua Kecamatan Ciputat Kota Tangerang Selatan dengan p-value sebesar 0,000 < 0,05, maka H0 ditolak dan H1 diterima.
Kata kunci: batuk, perilaku, pengetahuan, swamedikasi
Efektivitas Madu Hutan dan Krim Daun Singkong terhadap Penyembuhan Luka Bakar derajat-IIA
Authors: Jonaha Bonafide Tampubolon  , Runggu Retno J Napitupulu  , Hendra
Published: December 2024

Abstract—The skin is a line of defense in protecting the body from various trauma and injuries such as burns. Grade IIA burns are characterized by red, blistered skin and blisters. Treatment for grade IIA burns generally uses drugs such as sulfadiazine, povidone-iodine, MEBO. prices due to limited drug availability and side effects mean that alternative treatments using traditional ingredients are needed to treat burns. Honey and cassava leaves are traditional ingredients that can be used as an alternative for treating grade IIA burns. This research uses a pure experimental method with post test observations only with control group design. There was a difference in the average length of burn wounds after 14 days of treatment. Forest honey and cassava leaf extract cream are considered effective in healing grade IIA burns. The group of mice given honey had the smallest average length of burn wounds compared to the group given cassava leaf extract cream and followed by the positive control group given silver sulfadiazine and the negative control group without treatment. Thus, forest honey has the greatest effectiveness against grade IIA burns, compared to cassava leaves and the positive control. 
Keywords: burns, forest honey, cassava leaf cream
 
Abstrak—Kulit merupakan garis pertahanan dalam melindungi tubuh dari berbagai trauma dan cedera seperti luka bakar. Luka bakar derajat IIA ditandai dengan kulit kemerahan, melepuh dan melepuh. Penanganan luka bakar derajat IIA umumnya menggunakan obat-obatan seperti sulfadiazin, povidone-iodine, MEBO. Harga yang mahal akibat keterbatasan ketersediaan obat dan efek samping menyebabkan diperlukannya pengobatan alternatif dengan bahan-bahan tradisional untuk mengatasi luka bakar. Madu dan daun singkong merupakan bahan tradisional yang dapat digunakan sebagai alternatif penanganan luka bakar derajat IIA. Penelitian ini menggunakan metode eksperimen murni dengan rancangan post test observasi only with control group design. Terdapat perbedaan rerata panjang luka bakar setelah 14 hari perawatan. Krim madu hutan dan ekstrak daun singkong dinilai efektif dalam penyembuhan luka bakar derajat IIA. Kelompok mencit yang diberikan madu memiliki rerata panjang luka bakar paling kecil dibandingkan dengan kelompok yang diberikan krim ekstrak daun singkong dan diikuti oleh kelompok kontrol positif yang diberikan silver sulfadiazine dan kelompok kontrol negatif tanpa pengobatan. Dengan demikian, madu hutan mempunyai efektivitas paling besar terhadap luka bakar derajat IIA dibandingkan dengan daun singkong dan kontrol positif.
Kata kunci: luka bakar, madu hutan, krim daun singkong
PENAMBAHAN ZAT ADDITIVE ANTI STRIPPING AGENT DAN FILLER SERBUK PVC PADA CAMPURAN ASPAL AC-WC
Authors: Sriharyani Leni , Septiadi Dwi
Published: December 2024

Aspal merupakan bahan konstruksi utama dalam pembangunan jalan dengan tipe perkerasan lentur. Fenomena yang sering terjadi pada kontruksi jalan adalah pengelupasan lapisan antara agregat dan aspal yang biasa di kenal dengan sebutan stripping. Stripping merupakan salah satu kerusakan jalan yang sering terjadi pada perkerasan lapis aus (AC- WC) karena lapisan aus yang letaknya paling atas, sehingga lapisan tersebut langsung bersentuhan dengan roda kendaraan umum, panas matahari, dan air hujan. Untuk meningkatkan kualitas aspal yaitu dengan cara memodifikasi aspalnya, atau dengan menambahkan zat kimia daya ikat antara agregat dan aspal yaitu dengan cara menggunakan zat (additive) berupa anti pengelupasan (anti stripping agent). Menurut ASTM (1989) bahan pengisi (filler) harus terdiri dari material yang dapat dibagi secara halus seperti abu batu, terak, kapur, semen, abu terbang atau material mineral yang sesuai. Pada penelitian ini menggunakan serbuk PVC sebagai bahan tambah (filler) dalam campuran aspal PVC merupakan polimer termoplastik kedua yang paling banyak digunakan di seluruh dunia, setelah polietilen dan polipropilena. Penelitian ini menggunakan zat additive anti stripping agent 0%, 0,1%, 0,2%, 0,3%, 0,4% dan serbuk PVC 0%, 1%, 2%, 2,5%, 3% serta variasiAspal penetrasi shell 60/70 5%, 5,5%, 6%, 6,5%, 7%. Hasil penelitian pada additive anti stripping agent 0,2% dan serbuk PVC 2% didapat KAO 5,90% serta stabilitas sisa sebesar 90,91%. Menurut Spesifikasi Umum Bina Marga Tahun 2018 Revisi 2, batas minimal nilai stabilitas sisa yaitu 90% yang artinya pada campuran variasi additive anti stripping agent 0,2% dan serbuk PVC 2% sudah memenuhi persyaratan
INFRARED SPECTROSCOPIC ANALYSIS OF COMPLEX COPPER(II) CONTAINING CATALYTIC SYSTEM
Authors: Golub N.P. , Golub E.O. , Kozma A.A. , Savko V.M. , Mikhalchuk H.M. , Kuznyetsova A.O.
Published: December 2024

The synthesized 2 individual orthophosphate catalysts AlPO4 and Cu3(PO4)2 and 7 new complex aluminum-copper (II) orthophosphate catalytic systems of the type xAlPO4·yCu3(PO4)2 was obtained based on them were investigated by the method of IR spectroscopic analysis. At the same time, the content of both orthophosphates in the catalyst structure varies in the range of 0.5 - 99.5 wt. %. In the entire series of air-dry samples and those baked at the optimal heat treatment temperature (600 °С), the frequencies and intensities of the absorption bands of the IR spectra of the obtained catalytic systems of the type type xAlPO4·yCu3(PO4)2 are characterized by intense absorption in the region of valence vibrations of OH groups of water molecules (3610‒3005 cm-1). Valence vibrations of OH groups of water molecules, which take a direct part in the formation of hydrogen bonds, are observed in the region of 2380‒1880 cm-1. Characteristic manifestations of the hydrogen bond in the vibrational spectrum of H2O, which is part of the structure of the synthesized aluminum-copper (II) orthophosphate catalysts, are a low-frequency shift, an increase in intensity, and a broadening of the bands of valence vibrations of its OH groups. At the same time, in the region 1114‒400 cm-1, valence and deformation vibrations of the orthophosphate ion PO43- are observed, which are clearly expressed in the form of clear absorption bands in the dehydration products for all synthesized binary catalytic systems. Additional coordination of the orthophosphate anion with metal cations Al3+ and Сu2+ is observed. Heating all synthesized orthophosphate samples above 700 °С contributes to their complete dehydration and the emergence of IR spectra characteristic of anhydrous orthophosphate salts.
SYNTHESIS AND OPTICAL PROPERTIES OF POLYCRYSTALLINE Sb2S3 AND (Sb2S3)90Ag10
Authors: Pogodin A.I. , Filep M.J. , Studenyak Ya.I. , Gomonnai A.V.
Published: December 2024

Recently, much research has been devoted to finding new or improving existing photovoltaic materials. P-metal chalcogenides are attracting increasing attention due to their unique properties, including high photon absorption coefficient, significant dipole moment, optimal band gap and the ability to form solid solutions. To optimize the electrical parameters (band gap, concentration of charge carriers) in order to improve the performance of solar cells, the formation of doped compounds is used. In the present work, the synthesis and study of silver-doped polycrystalline Sb2S3 was carried out. The obtained alloys were characterized by X-ray diffraction and diffuse reflectance spectroscopy. The phase composition of the synthesized alloys was determined by X-ray diffraction method. The powder patterns of the (Sb2S3)90Ag10 alloy contains two systems of reflexes: those corresponding to the Sb2S3 and ternary AgSbS2 phases. The optical parameters of the synthesized materials were studied by diffuse reflectance spectroscopy method. The diffuse reflectance spectra were analyzed using the Kubelka-Munk function. The pseudogap was determined using the Tauc method.
THE FIRST STEPS OF LEARNING CHEMISTRY IN THE NEW UKRAINIAN SCHOOL: SELF-ASSESSMENT RESULTS
Authors: Zubaka O.V. , Barchii I.Ye. , Pogodin A.I. , Lapko M.I. , Zavadska I.K. , Fedak-Poshtak N.V. , Goncharova O.M. , Zalutska S.B.
Published: December 2024

Self-assessment becomes an important element in the modern educational process, in particular when studying chemistry. Modern approaches to education are aimed not only at the transfer of knowledge, but also at the development of students' ability to independently evaluate their achievements and identify difficulties in learning the material. Thanks to this, students learn to approach their studies more responsibly, become more independent and motivated. Self-assessment is a key component of modern methodological approaches in teaching, as it contributes to the development of independence, critical thinking and personal responsibility of students. In this work, the results of self-assessment by students of the first chapter of chemistry «Chemistry. The first steps» were investigated and analyzed. The 7th grade students of the A. Voloshyn Uzhhorod Lyceum, who started studying chemistry under the program of the New Ukrainian School. The results of the study showed the level of assimilation of the material passed by students and insufficient understanding of the history of the development of chemistry, the consequences of non-observance of safety techniques while working in the chemical laboratory, difficulties in the systematization of laboratory equipment. Such an analysis will help to more effectively adapt the educational process to the needs of students and improve their results.
ON THE INITIAL VERIFICATION OF THE CRYSTAL STRUCTURES OF THE ARGYRODITE FAMILY
Authors: Kokhan O.P. , Sidey V.I.
Published: December 2024

The crystal structures of the phases belonging to the scientifically and technologically important family of argyrodites of the general chemical formula Am+(12–n–x)/mBn+X2–6–xY–x (where A = Li+; Cu+, Ag+, Cd2+, Hg2+…; B = Ga3+, Si4+, Ge4+, Sn4+, P5+, As5+…; X = O2–; S2–, Se2–, Te2–; Y = Cl–, Br–, I–; 0 ≤ x ≤ 1) are characterized by high mobility and disorder of the cationic sublattice (substructure) A. This feature of argyrodites makes them promising solid-state ionic conductors, but significantly complicates the X-ray analysis of argyrodite phases due to the inability to reliably predict the positions of A ions in the unit cell of the crystal structure of a particular argyrodite sample and the site occupancy factors of these positions.
The analysis of the published structures of argyrodites has revealed the fact that the positions of typical B cations and their X ligands in the tetrahedral environment [BX4] are fully occupied by the corresponding ions, which makes it possible to perform an initial verification of the structural models of the argyrodite phases (already published in the scientific literature or newly obtained) within the framework of the bond valence model (BVM) – by calculating the bond valence sums for the B cations from the interatomic distances dBX in the coordination tetrahedra [BX4]. In addition to the initial verification of structural models of argyrodite phases, the use of the BVM with the numerical parameters recommended in this work allows researchers to create reliable starting partial structural models of argyrodite phases for their further refinement by X-ray diffraction analysis, as well as to stabilize the process of refining the crystal structure by imposing soft restraints on the deviation of the calculated interatomic distances dBX from the predicted distances in the [BX4] tetrahedra.
INVESTIGATION OF THE INFLUENCE OF THE CHEMICAL STRUCTURE OF PPI DRUGS ON THEIR ADMET PROFILE
Authors: Korol N.I. , Frevlyk R.M. , Slivka M.V.
Published: December 2024

Proton pump inhibitors (PPIs) are widely used to reduce stomach acid production and treat conditions such as gastroesophageal reflux disease, gastritis, peptic ulcers, and Barrett's esophagus. Proton pump inhibitors are also often used in combination with non-steroidal anti-inflammatory drugs for the prevention of erosions and ulcers of the gastrointestinal tract.
In the present study, an ADMET analysis (absorption, distribution, metabolism, excretion and toxicity) of three major Proton pump inhibitors, omeprazole, pantoprazole and esomeprazole, was performed. The analysis was performed using the ADMETlab platform, with the help of which pharmacokinetic properties were investigated. It was established that all three drugs meet the criteria for oral administration, have similar molecular weight and properties that ensure their effectiveness and safety in clinical use. The influence of the chemical structure of these drugs on their pharmacological properties was additionally analyzed and the best drug was determined based on the results obtained.