bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrahigh Extinction Ratio Leaky-Guided Hollow Core Fiber Mach–Zehnder Interferometer Assisted by a Large Core Hollow Fiber Beam Splitter
Authors: Lu Yan-Han , Luo Ren-Xiang , Lee Cheng-Ling
Published: September 2024

We proposed a novel fiber Mach–Zehnder interferometer (FMZI) that can perform an ultrahigh extinction ratio (ER), ultracompact, and ultra-broadband interference characteristics. The FMZI structure is based on an extremely tiny hollow core fiber (HCF) with a small diameter of 10 μm (named HCF10) connected with a beam splitter of a large core of 50 μm HCF (named HCF50). The refractive index (RI) of the air core is lower than that of the HCF cladding; a leaky-guided fiber waveguide (LGFW) occurs in such a short-section HCF10 waveguide to simultaneously have the core and cladding modes. To achieve better fringe visibility of the interference, the section of HCF50 assists in splitting the optical light into core and cladding beams launched into the HCF10 with appropriate intensities. Experimental and simulation results show that the optical characteristics of the proposed LGFW-FMZI are very similar. Based on the results of the study, the length of the HCF10 primarily influences the free spectral range (FSR) of the interference spectra, and the HCF50 splitter significantly controls the optimal extinction ratio (ER) of the interference fringes. By exactly adjusting the lengths of HCF10 and HCF50, the proposed fiber interferometers can perform the capability of an ultrahigh ER over 50 dB with the arbitrary FSR in the transmitted interference spectra over an ultra-broad wavelength range of 1250 nm to 1650 nm.
Recent Advances in Wearable Textile-Based Triboelectric Nanogenerators
Authors: Neelakandan Sivasubramaniyan , Srither S. R. , Dhineshbabu N. R. , Maloji Suman , Dahlsten Oscar , Balaji Ramachandran , Singh Ragini
Published: September 2024

We review recent results on textile triboelectric nanogenerators (T-TENGs), which function both as harvesters of mechanical energy and self-powered motion sensors. T-TENGs can be flexible, breathable, and lightweight. With a combination of traditional and novel manufacturing methods, including nanofibers, T-TENGs can deliver promising power output. We review the evolution of T-TENG device structures based on various textile material configurations and fabrication methods, along with demonstrations of self-powered systems. We also provide a detailed analysis of different textile materials and approaches used to enhance output. Additionally, we discuss integration capabilities with supercapacitors and potential applications across various fields such as health monitoring, human activity monitoring, human–machine interaction applications, etc. This review concludes by addressing the challenges and key research questions that remain for developing viable T-TENG technology.
Comparative SERS Activity of Homometallic and Bimetallic Core–Satellite Assemblies
Authors: Terrones-Morey Gianfranco , Xiao Xiaofei , Giannini Vincenzo , Fragoso Alex , Guerrini Luca , Pazos-Perez Nicolas
Published: September 2024

The fabrication of core–satellite (CS) assemblies offers a versatile strategy for tailoring the optical properties of plasmonic nanomaterials. In addition to key factors like size, shape, and spatial arrangement of individual components, the combination of plasmonic units with different compositions (e.g., gold and silver) has been demonstrated to produce materials with enhanced properties and functionalities applicable across a range of fields. Notably, several CS assembly variants have emerged as promising substrates for surface-enhanced Raman spectroscopy (SERS). In this study, we address a gap in the knowledge by conducting a systematic cross-comparison of the optical and SERS properties of highly bright homo- and bimetallic CS assemblies. We evaluated the SERS efficiencies of these different superstructures across various excitation wavelengths and supported our findings with numerical simulations. The insights gained from this study offer a valuable foundation for researchers seeking to select and optimize the most suitable CS assemblies for their given SERS application.
Low-Protein Diets, Malnutrition, and Bone Metabolism in Chronic Kidney Disease
Authors: Pereira Cidália D. , Guimarães Carla , Ribeiro Vânia S. , Vaz Daniela C. , Martins Maria João
Published: September 2024

Chronic kidney disease (CKD) has a high prevalence worldwide, with increasing incidence in low- and middle-income countries, and is associated with high morbidity and mortality, particularly from cardiovascular disease. Protein-restricted diets are one of the most widely used non-pharmacological approaches to slow the progression of CKD and prevent associated metabolic abnormalities. However, some concerns have been raised about the long-term safety of these diets, particularly with regard to patients’ nutritional status and bone and mineral disorders. Therefore, the aim of this article is to review the most recent scientific evidence on the relevance of using protein-restricted diets (with or without keto-analogue supplementation) and, in particular, their relationships with malnutrition and mineral and bone disorders in people with CKD without kidney replacement therapies. Although protein-restricted diets, especially when supplemented with keto-analogues and highly personalized and monitored, do not appear to be associated with malnutrition, research on their effects on bone and mineral disorders is scarce, deserving further investigation.
A Comparative Study on the Dietary Iodine Intake and the Contribution Rates of Various Foods to the Dietary Iodine Intake among Residents in Zhejiang in 2010 and 2022
Authors: He Jiaxin , Huang Lichun , Gu Simeng , Mo Zhe , Su Danting , Liu Chenyang , Guo Fanjia , Wang Yuanyang , Chen Zhijian , Zhang Ronghua , Lou Xiaoming , Mao Guangming , Wang Xiaofeng
Published: September 2024

We aim to analyze the changes in dietary iodine intake and the contribution rates of various foods to it after the reduction in salt iodine concentration in Zhejiang. We used data from two cross-sectional nutrition surveillance surveys conducted by the Zhejiang Provincial Center for Disease Control and Prevention in 2010 (9798 residents) and 2022 (5980 residents). In both surveys, multi-stage stratified and systematic sampling were adopted, and uniformly trained investigators conducted the dietary surveys using a 24 h dietary review and weighing record methods for 3 consecutive days. From 2010 to 2022, the median salt iodine concentration and the consumption rate of qualified iodized salt in Zhejiang households dropped from 28.80 to 22.08 mg/kg and from 76.65% to 64.20%, respectively. Moreover, the residents’ median dietary iodine intake decreased from 277.48 to 142.05 μg/d. Significant interregional differences in dietary iodine intake were found in 2010 and 2022 (H = 639.175, p < 0.001; H = 588.592, p < 0.001, respectively); however, no significant differences existed between urban and rural areas (p > 0.05). From 2010 to 2022, the proportion of residents with dietary iodine intake below the estimated average requirement increased from 15.10% to 34.80%, while that of residents with intake above the tolerable upper limit decreased from 15.00% to 2.90%. The contribution rate of salt to dietary iodine intake among residents in Zhejiang decreased from 74.92% to 48.54%, showing an apparent overall downward trend despite the dietary intake being generally adequate (markedly inadequate in coastal regions). The salt iodine concentration and the consumption rate of qualified iodized salt in households in Zhejiang showed downward trends. Salt remained the main source of dietary iodine; however, its contribution decreased significantly. Zhejiang may need to reverse the trend of the continuous decline in the consumption rate of qualified iodized salt to protect the health of its residents.
Nutrition and Periodontitis: A Cross-Sectional Study from a Practice-Based Research Network
Authors: Peikert Stefanie Anna , Liedtke Nils Benedikt , Vach Kirstin , Streletz Eva , Rieger Steffen , Palm Julia , Mittelhamm Felix , Kirchner Sebastian , Hakes Peter , Gantert Laurence , Cansado De Noriega Carmen , Kruse Anne Brigitte , Ratka-Krüger Petra , Woelber Johan Peter
Published: September 2024

Background: Despite clinical interventional studies on the influence of diet on periodontal inflammatory parameters, there has been no practice-based cross-sectional study from a German population to date that has conducted both a comprehensive dental and periodontal examination and a thorough validated assessment of dietary behavior. Therefore, the aim of this pilot study was to evaluate, in a proof of concept, whether there is a correlation between the overall periodontal inflammatory surface area (PISA), periodontal clinical parameters (pocket probing depths (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), furcation involvement (FI), tooth mobility (TM)), and the dietary behavior of patients with periodontal disease when utilizing a practice-based research network. The primary outcome was the correlation between the periodontal inflammatory surface (PISA) and the dietary assessment data. Materials and Methods: The practice-based research network, consisting of eight Master’s graduates, recruited patients who met the inclusion and exclusion criteria and performed a periodontal examination together with the assessment of dietary behavior using a digital version of the validated retrospective dietary recall (DEGS/RKI). Statistical analyses included linear regression models adjusted for age and smoking and unpaired t-tests, conducted using STATA 17.0 with a significance level of 5%. In addition, the data obtained were classified according to the currently recommended amounts of daily intake. Results: A total of 1283 teeth were analyzed, with 60.25% (773 teeth) requiring treatment. The average PISA was 753.16 mm2 (SD ± 535.75 mm). Based on dietary guidelines, the studied population consumed excessive amounts of extrinsic sugars and fats, while their fiber and legume intake was insufficient. The intake of certain nutrients, including water-soluble fibers, specific fatty acids, vitamins (D, B1, B2, B6, and B12), iron, and zinc, was associated with reduced PISA, PPD, CAL, and BOP. Conclusion: Within the limits of the current study, including its cross-sectional design and cohort size, the outcomes demonstrated the influence of nutrition on periodontal health.
Hesperetin Attenuates T-2 Toxin-Induced Chondrocyte Injury by Inhibiting the p38 MAPK Signaling Pathway
Authors: Lu Chunqing , Yang Wenjing , Chu Fang , Wang Sheng , Ji Yi , Liu Zhipeng , Yu Hao , Qin Shaoxiao , Sun Dianjun , Jiao Zhe , Sun Hongna
Published: September 2024

Background: Hesperetin, a flavonoid derived from citrus fruits, exhibits potent antioxidant and anti-inflammatory activities and has been implicated in cartilage protection. However, its effectiveness against T-2 toxin-induced knee cartilage damage remains unclear. Methods: In this study, high-throughput sequencing analysis was employed to identify the key signaling pathways involved in T-2 toxin-induced articular cartilage damage in rats. Animal models were divided into the following groups: control, low-dose T-2 toxin, high-dose T-2 toxin, T-2 toxin + hesperetin, hesperetin, and vehicle. Pathological staining and immunohistochemistry were used to assess pathological changes, as well as the expression levels of the cartilage matrix-related proteins MMP13 and collagen II, along with the activation of the p38 MAPK signaling pathway. Additionally, primary rat chondrocytes were cultured to establish an in vitro model for investigating the underlying mechanism. Results: High-throughput sequencing analysis revealed the involvement of the MAPK signaling pathway in T-2 toxin-induced articular cartilage damage in rats. Hesperetin intervention in T-2 toxin-exposed rats attenuated pathological cartilage damage. Immunohistochemistry results demonstrated a significant reduction in collagen II protein expression in the high-dose T-2 toxin group (p < 0.01), accompanied by a significant increase in MMP13 protein expression (p < 0.01). In both the articular cartilage and the epiphyseal plate, the T-2 toxin + hesperetin group exhibited significantly higher collagen II protein expression than the high-dose T-2 toxin group (p < 0.05), along with significantly lower MMP13 protein expression (p < 0.05). Hesperetin inhibited the over-activation of the p38/MEF2C signaling axis induced by T-2 toxin in primary rat chondrocytes. Compared to the T-2 toxin group, the T-2 toxin + hesperetin group showed significantly reduced phosphorylation levels of p38 and protein expression levels of MEF2C (p < 0.001 or p < 0.05). Moreover, the T-2 toxin + hesperetin group exhibited a significant decrease in MMP13 protein expression (p < 0.05) and a significant increase in collagen II protein expression (p < 0.01) compared to the T-2 toxin group. Conclusions: T-2 toxin activates the p38 MAPK signaling pathway, causing knee cartilage damage in rats. Treatment with hesperetin inhibits the p38/MEF2C signaling axis, regulates collagen II and MMP13 protein expression, and reduces cartilage injury significantly.
Understanding the Health Literacy Experiences and Practices of Australian-Resettled Myanmar Refugees: Relevance for Nutrition and Dietetics Practice
Authors: Wong Carrie K. , Lassemillante Annie-Claude , White Carolynne , Belski Regina
Published: September 2024

Background/Objectives: Refugees typically experience poorer health compared with people from non-refugee backgrounds, and health literacy may play a part in this discrepancy. Using the WHO’s revised health literacy definitions as a framework, this qualitative study sought to examine the health literacy experiences and practices of Australian resettled refugees from Myanmar from refugee and service provider perspectives. Methods: Four refugee participant focus groups (n = 27) along with one focus group and four interviews with service providers (n = 7) were conducted in Melbourne, Australia, and analysed using deductive content analysis. Results: Our study found that in addition to individual health literacy, community literacy was practiced by Myanmar refugees, thus highlighting the relevance of social support to health literacy. Furthermore, our study found gaps in healthcare service provision and resourcing related to health literacy development and responsiveness by the healthcare system. Conclusions: Our study confirms the relevance of WHO’s revised health literacy definitions to Myanmar refugees while also discussing, in the context of nutrition and dietetics practice, the importance of understanding the different aspects of health literacy and how this relates to working with those who are most marginalised to improve their health and wellbeing.
The Temporal Change in Ionised Calcium, Parathyroid Hormone and Bone Metabolism Following Ingestion of a Plant-Sourced Marine Mineral + Protein Isolate in Healthy Young Adults
Authors: Kozior Marta , Demehin Olusoji Aboyeji , Ryan Michelle Mary , O’Connell Shane , Jakeman Philip Michael
Published: September 2024

Background: An increase in plant-sourced (PS) nutrient intake is promoted in support of a sustainable diet. PS dietary minerals and proteins have bioactive properties that can affect bone health and the risk of fracture. Methods: In a group randomised, cross-over design, this study evaluated the post-ingestion temporal pattern of change in arterialised ionised calcium (iCa), parathyroid hormone (PTH), C-terminal crosslinked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP) for 4 h following ingestion of a novel supplement (SUPP) containing a PS marine multi-mineral + PS protein isolate. A diurnally matched intake of mineral water was used as a control (CON). Results: Compared to baseline, the change in iCa concentration was 0.022 (95% CI, 0.006 to 0.038, p = 0.011) mmol/l greater in SUPP than CON, resulting in a −4.214 (95% CI, −8.244 to −0.183, p = 0.042) pg/mL mean reduction in PTH, a −0.64 (95% CI, −0.199 to −0.008, p = 0.029) ng/mL decrease in the biomarker of bone resorption, CTX, and no change in the biomarker of bone formation, P1NP. Conclusions: When used as a dietary supplement, or incorporated into a food matrix, the promotion of PS marine multi-mineral and PS protein isolates may contribute to a more sustainable diet and overall bone health.
Sum of Skinfold-Corrected Girths Correlates with Resting Energy Expenditure: Development of the NRGCO Equation
Authors: Restrepo-Botero Diego A. , Rincón-Yepes Camilo A. , Franco-Hoyos Katherine , Agudelo-Martínez Alejandra , Cardozo Luis A. , Duque-Zuluaga Leidy T. , Vélez-Gutiérrez Jorge M. , Rojas-Jaramillo Andrés , Petro Jorge L. , Kreider Richard B. , Cannataro Roberto , Bonilla Diego A.
Published: September 2024

Our study aimed to validate existing equations and develop the new NRGCO equation to estimate resting energy expenditure (REE) in the Colombian population with moderate-to-high physical activity levels. Upon satisfying the inclusion criteria, a total of 86 (43F, 43M) healthy adults (mean [SD]: 27.5 [7.7] years; 67.0 [13.8] kg) were evaluated for anthropometric variables and REE by indirect calorimetry using wearable gas analyzers (COSMED K4 and K5). Significant positive correlations with REE were found for body mass (r = 0.65), body mass-to-waist (r = 0.58), arm flexed and tensed girth (r = 0.66), corrected thigh girth (r = 0.56), corrected calf girth (r = 0.61), and sum of breadths (∑3D, r = 0.59). As a novelty, this is the first time a significant correlation between REE and the sum of corrected girths (∑3CG, r = 0.63) is reported. Although existing equations such as Harris–Benedict (r = 0.63), Mifflin–St. Jeor (r = 0.67), and WHO (r = 0.64) showed moderate-to-high correlations with REE, the Bland-Altman analysis revealed significant bias (p < 0.05), indicating that these equations may not be valid for the Colombian population. Thus, participants were randomly distributed into either the equation development group (EDG, n = 71) or the validation group (VG, n = 15). A new model was created using body mass, sum of skinfolds (∑8S), corrected thigh, corrected calf, and age as predictors (r = 0.755, R2 = 0.570, RMSE = 268.41 kcal). The new NRGCO equation to estimate REE (kcal) is: 386.256 + (24.309 × BM) − (2.402 × ∑8S) − (21.346 × Corrected Thigh) + (38.629 × Corrected Calf) − (7.417 × Age). Additionally, a simpler model was identified through Bayesian analysis, including only body mass and ∑8S (r = 0.724, R2 = 0.525, RMSE = 282.16 kcal). Although external validation is needed, our validation resulted in a moderate correlation and concordance (bias = 91.5 kcal) between measured and estimated REE values using the new NRGCO equation.
Neither an Individualised Nor a Standardised Sodium Bicarbonate Strategy Improved Performance in High-Intensity Repeated Swimming, or a Subsequent 200 m Swimming Time Trial in Highly Trained Female Swimmers
Authors: Newbury Josh W. , Cole Matthew , Kelly Adam L. , Gough Lewis A.
Published: September 2024

Inconsistent swimming performances are often observed following sodium bicarbonate (NaHCO3) ingestion, possibly because the time taken to reach peak blood buffering capacity is highly variable between individuals. Personalising NaHCO3 ingestion based on time-to-peak blood bicarbonate (HCO3−) could be a solution; however, this strategy is yet to be explored in swimming, or adequately compared to standardised NaHCO3 approaches. Therefore, six highly trained female swimmers ingested 0.3 g·kg BM−1 NaHCO3 in capsules to pre-determine their individual time-to-peak blood HCO3−. They then participated in three experimental trials, consisting of a 6 × 75 m repeated sprint swimming test, followed by a 200 m maximal time trial effort after 30 min active recovery. These experiments were conducted consuming a supplement at three different timings: individualised NaHCO3 (IND: 105–195 min pre-exercise); standardised NaHCO3 (STND: 150 min pre-exercise); and placebo (PLA: 90 min pre-exercise). Both NaHCO3 strategies produced similar increases in blood HCO3− prior to exercise (IND: +6.8 vs. STND: +6.1 mmol·L−1, p < 0.05 vs. PLA) and fully recovered blood HCO3− during active recovery (IND: +6.0 vs. STND: +6.3 mmol·L−1 vs. PLA, p < 0.05). However, there were no improvements in the mean 75 m swimming time (IND: 48.2 ± 4.8 vs. STND: 48.9 ± 5.8 vs. PLA: 49.1 ± 5.1 s, p = 0.302) nor 200 m maximal swimming (IND: 133.6 ± 5.0 vs. STND: 133.6 ± 4.7 vs. PLA: 133.3 ± 4.4 s, p = 0.746). Regardless of the ingestion strategy, NaHCO3 does not appear to improve exercise performance in highly trained female swimmers.
Efficacy, Safety and Acceptability of a Very-Low-Energy Diet in Adolescents with Obesity: A Fast Track to Health Sub-Study
Authors: Gow Megan L. , Jebeile Hiba , House Eve T. , Alexander Shirley , Baur Louise A. , Brown Justin , Collins Clare E. , Cowell Chris T. , Day Kaitlin , Garnett Sarah P. , Grunseit Alicia , Inkster Mary-Kate , Kwok Cathy , Lang Sarah , Paxton Susan J. , Truby Helen , Varady Krista A. , Lister Natalie B.
Published: September 2024

The aim of this study was to determine the efficacy, safety and acceptability of a 4-week very-low-energy diet (VLED) program for adolescents with obesity. Adolescents (13–17 years) with obesity and ≥1 obesity-related complication were Fast Track to Health 52-week randomized controlled trial participants. Adolescents undertook a 4-week micronutrient-complete VLED (800 kcal/day), with weekly dietitian support. Anthropometric data were recorded at baseline and week-4 and side-effects at day 3–4, week-1, -2, -3 and -4. Adolescents completed an acceptability survey at week-4. A total of 134 adolescents (14.9 ± 1.2 years, 50% male) had a 5.5 ± 2.9 kg (p < 0.001) mean weight loss at week-4: 95% experienced ≥1 and 70% experienced ≥3 side-effects during the VLED program, especially during the first week. Hunger, fatigue, headache, irritability, loose stools, constipation and nausea were most common. Reporting more side-effects at day 3–4 correlated with greater weight loss at week-4 (r = −0.188, p = 0.03). Adolescents reported ‘losing weight’ (34%) and ‘prescriptive structure’ (28%) as the most positive aspects of VLED, while ‘restrictive nature’ (45%) and ‘meal replacement taste’ (20%) were least liked. A dietitian-monitored short-term VLED can be implemented safely and is acceptable for many adolescents seeking weight loss, despite frequent side-effects. Investigating predictors of acceptability and effectiveness could determine adolescents most suited to VLED programs.
Complementary Feeding in the Clinical Practice: An Exploratory Survey among Italian Primary Care Pediatricians
Authors: Capra Maria Elena , Decarolis Nicola Mattia , Stanyevic Brigida , Giudice Antonella , Monopoli Delia , Neglia Cosimo , Ramundo Greta , Esposito Susanna , Biasucci Giacomo
Published: September 2024

Introduction: Complementary feeding (CF) is the process of introducing solid or liquid foods (complementary foods, CFs) other than human breast milk (HBM) or infant formula into infants’ diet when HBM or infant formula is no longer sufficient to meet infants’ nutritional needs. Primary care pediatricians (PCPs) are paramount in guiding and educating infants’ families during CF. Materials and Methods: Our exploratory survey aimed to investigate PCPs’ current clinical approach to managing CF. From 1 March 2024 to 30 April 2024, a digital questionnaire composed of 32 multiple-choice questions investigating PCPs’ attitudes toward CF in healthy, full-term infants was proposed to 1620 PCPs contacted through scientific societies. Results: The questionnaire was completed voluntarily; 707 PCPs (79.5% female, 66.1% aged over 50 years) fully responded to the survey in the proposed timeframe (participation rate 43.6%). Among the responders, 47.5% recommended traditional CF; 42.1% declared to know the baby-led weaning (BLW) approach and on-demand CF (ODCF), but only 32.8% and 12.5% of them recommended these types of CF, respectively. The vast majority (95%) of participants recommended that CF start between 4 to 6 completed months of age. CF routinely based on vegetarian or plant-based diets was supported by 45/707 (6.1%), only if planned by a specialist by 253/707 (35.8%), and only upon request by caregivers by 257/707 (36.3%). Egg and fish introduction was mostly advised in the first year of life, although in case of a positive family history of food allergy, 13.3% of participants recommended the introduction of egg and fish after 12 months. Conclusions: In conclusion, PCPs did not display a homogenous approach to CF; further studies and educational programs are needed to achieve more flexibility and knowledge on this important nutritional issue.
Nutrition and Selected Lifestyle Elements as a Tertiary Prevention in Colorectal Cancer Patients
Authors: Mąkosza Kamil Michał , Muc-Wierzgoń Małgorzata , Dzięgielewska-Gęsiak Sylwia
Published: September 2024

Background. Nutrition and lifestyle elements can significantly support the therapeutic process in colorectal cancer (CRC) patients, which is the basis for tertiary prevention. The study aimed to assess the nutritional strategies and lifestyle of CRC patients and to determine differences in these behaviors depending on gender and age. Methods. The study group included 202 CRC patients. The research was carried out in two hospitals and using the snowball method. The research tool was an original questionnaire. Data were processed in statistical programs. p < 0.05 was considered statistically significant. Results. Patients reported many behavioral–nutritional side effects. Half of them did not use a therapeutic diet (n = 101; 50.0%). The majority of patients declared that they ate three meals a day (57.4%). Fruits and vegetables were mainly eaten raw (69.3%). Almost a quarter of patients were not physically active at all (22.3%). Men chose to fry meat significantly more often than women (27.7% vs. 19.3%) (p = 0.003). The elderly consumed fast food significantly less often than middle-aged (88.5% vs. 72.3%) (p = 0.03). Conclusions. Patients showed both pro- and anti-health activities. The findings revealed several noteworthy disparities in dietary habits and lifestyle choices based on gender and age, indicating that these factors can significantly influence the health management of CRC patients. The patients’ behaviors should be constantly monitored and intensified, especially through regular consultations and educational meetings with an oncology dietitian for nutritional tertiary prevention of chronic disease.
Effects and Mechanisms of Polyunsaturated Fatty Acids on Age-Related Musculoskeletal Diseases: Sarcopenia, Osteoporosis, and Osteoarthritis—A Narrative Review
Authors: Chen Haoqi , Xiong Ruogu , Cheng Jin , Ye Jialu , Qiu Yingzhen , Huang Siyu , Li Mengchu , Liu Zhaoyan , Pang Jinzhu , Zhang Xuguang , Guo Shanshan , Li Huabin , Zhu Huilian
Published: September 2024

Background: The process of the globally aging population has been accelerating, leading to an increasing social burden. As people age, the musculoskeletal system will gradually go through a series of degenerative and loss of function and eventually develop age-related musculoskeletal diseases, like sarcopenia, osteoporosis, and osteoarthritis. On the other hand, several studies have shown that polyunsaturated fatty acids (PUFAs) possess various important physiological functions on the health of muscles, bones, and joints. Objective: This narrative review paper provides a summary of the literature about the effects and mechanisms of PUFAs on age-related musculoskeletal diseases for the prevention and management of these diseases. Methods: Web of Science, PubMed, Science Direct, and Scopus databases have been searched to select the relevant literature on epidemiological, cellular, and animal experiments and clinical evidence in recent decades with keywords “polyunsaturated fatty acids”, “PUFAs”, “omega-3”, “omega-6”, “musculoskeletal diseases”, “sarcopenia”, “osteoporosis”, “osteoarthritis”, and so on. Results: PUFAs could prevent and treat age-related musculoskeletal diseases (sarcopenia, osteoporosis, and osteoarthritis) by reducing oxidative stress and inflammation and controlling the growth, differentiation, apoptosis, and autophagy of cells. This review paper provides comprehensive evidence of PUFAs on age-related musculoskeletal diseases, which will be helpful for exploitation into functional foods and drugs for their prevention and treatment. Conclusions: PUFAs could play an important role in the prevention and treatment of sarcopenia, osteoporosis, and osteoarthritis.
From the “One-Molecule, One-Target, One-Disease” Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) Infections
Authors: Roux Hugo , Touret Franck , Rathelot Pascal , Vanelle Patrice , Roche Manon
Published: September 2024

Non-polio enteroviruses (NPEVs), namely coxsackieviruses (CV), echoviruses (E), enteroviruses (EV), and rhinoviruses (RV), are responsible for a wide variety of illnesses. Some infections can progress to life-threatening conditions in children or immunocompromised patients. To date, no treatments have been approved. Several molecules have been evaluated through clinical trials without success. To overcome these failures, the multi-target directed ligand (MTDL) strategy could be applied to tackle enterovirus infections. This work analyzes registered clinical trials involving antiviral drugs to highlight the best candidates and develops filters to apply to a selection for MTDL synthesis. We explicitly stated the methods used to answer the question: which solution can fight NPEVs effectively? We note the originality and relevance of this proposal in relation to the state of the art in the enterovirus-inhibitors field. Several combinations are possible to broaden the antiviral spectrum and potency. We discuss data related to the virus and data related to each LEAD compound identified so far. Overall, this study proposes a perspective on different strategies to overcome issues identified in clinical trials and evaluate the “MTDL” potential to improve the efficacy of drugs, broaden the antiviral targets, possibly reduce the adverse effects, drug design costs and limit the selection of drug-resistant virus variants.
Assessment of Enzymatically Derived Blackcurrant Extract as Cosmetic Ingredient—Antioxidant Properties Determination and In Vitro Diffusion Study
Authors: Petrov Ivanković Anja , Ćorović Marija , Milivojević Ana , Blagojević Stevan , Radulović Aleksandra , Pjanović Rada , Bezbradica Dejan
Published: September 2024

Blackcurrant is an anthocyanin-rich berry with proven antioxidant and photoprotective activity and emerging prebiotic potential, widely applied in cosmetic products. Hereby, highly efficient enzyme-assisted extraction of blackcurrant polyphenols was performed, giving extract with very high antioxidant activity. Obtained extract was characterized in terms of anthocyanin composition, incorporated into three different cosmetic formulations and subjected to Franz cell diffusion study. Experimental values obtained using cellulose acetate membrane for all four dominant anthocyanins (delphinidin 3-glucoside, delphinidin 3-rutinoside, cyanidin 3-glucoside and cyanidin 3-rutinoside) were successfully fitted with the Korsmeyer–Peppas diffusion model. Calculated effective diffusion coefficients were higher for hydrogel compared to oil-in-water cream gel and oil-in-water emulsion, whereas the highest value was determined for cyanidin 3-rutinoside. On the other hand, after a 72 h long experiment with transdermal skin diffusion model (Strat-M® membrane), no anthocyanins were detected in the receptor fluid, and only 0.5% of the initial quantity from the donor compartment was extracted from the membrane itself after experiment with hydrogel. Present study revealed that hydrogel is a suitable carrier system for the topical delivery of blackcurrant anthocyanins, while dermal and transdermal delivery of these molecules is very limited, which implies its applicability for treatments targeting skin surface (i.e., prebiotic, photoprotective).
Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules
Authors: Tepper-Shimshon Odelia , Tetro Nino , Hamed Roa’a , Erenburg Natalia , Merquiol Emmanuelle , Dey Gourab , Haim Agam , Dee Tali , Duvdevani Noa , Kevorkian Talin , Blum Galia , Yavin Eylon , Eyal Sara
Published: September 2024

The space environment can affect the function of all physiological systems, including the properties of cell membranes. Our goal in this study was to explore the effect of simulated microgravity (SMG) on the cellular uptake of small molecules based on reported microgravity-induced changes in membrane properties. SMG was applied to cultured cells using a random-positioning machine for up to three hours. We assessed the cellular accumulation of compounds representing substrates of uptake and efflux transporters, and of compounds not shown to be transported by membrane carriers. Exposure to SMG led to an increase of up to 60% (p < 0.01) in the cellular uptake of efflux transporter substrates, whereas a glucose transporter substrate showed a decrease of 20% (p < 0.05). The uptake of the cathepsin activity-based probe GB123 (MW, 1198 g/mol) was also enhanced (1.3-fold, p < 0.05). Cellular emission of molecules larger than ~3000 g/mol was reduced by up to 50% in SMG (p < 0.05). Our findings suggest that short-term exposure to SMG could differentially affect drug distribution across membranes. Longer exposure to microgravity, e.g., during spaceflight, may have distinct effects on the cellular uptake of small molecules.
Strain of Xanthomonas oryzae pv. oryzae Loses Virulence through Dysregulation of Cardiolipin Synthase
Authors: Hu Yiqun , Chen Qingqing , Zhang Aifang , Zhang Liyuan , Dong Hansong
Published: September 2024

Small non-coding RNAs (sRNAs) are pivotal post-transcriptional regulatory factors influencing biological activity. Studies on the rice bacterial blight pathogen Xanthomonas oryzae pathovar oryzae strain PXO99A, previously identified a virulence-associated sRNA, trans3287. A mutant strain lacking this sRNA, named SK01, resulted in markedly diminished virulence towards rice. This study aims to further elucidate the underlying bacterial virulent function of trans3287. The expression of trans3287 was quantified in virulence-inducing and standard nutritional conditions to clarify its production mechanism. The detection of virulence-associated genes revealed that trans3287 regulated the synthesis processes of extracellular polysaccharides, lipopolysaccharides, and the type III secretion system. Moreover, bioinformatics prediction and quantitative PCR indicated a potential direct target of trans3287, PXO_03470, encoding cardiolipin synthase. A dual-plasmid system fusing with GFP tag and protein immunoblotting confirmed that sRNA trans3287 negatively regulated PXO_03470. Bacterial biofilms demonstrated trans3287 regulated the disruption of biofilm integrity through cardiolipin synthase. This study provides preliminary insights into the mechanistic underpinnings of the role of sRNA trans3287 in mediating bacterial virulence through cardiolipin synthase.
Investigating Additive Manufacturing Possibilities for an Unmanned Aerial Vehicle with Polymeric Materials
Authors: Šostakaitė Laura , Šapranauskas Edvardas , Rudinskas Darius , Rimkus Arvydas , Gribniak Viktor
Published: September 2024

Fused filament fabrication, also known as fused deposition modeling and 3D printing, is the most common additive manufacturing technology due to its cost-effectiveness and customization flexibility compared to existing alternatives. It may revolutionize unmanned aerial vehicle (UAV) design and fabrication. Therefore, this study hypothesizes the 3D printing possibility of UAV using a simple desktop printer and polymeric material. The extensive literature analysis identified the acceptable prototyping object and polymeric material. Thus, the research focuses on applying polylactic acid (PLA) in manufacturing the flying wing-type UAV and develops a fabrication concept to replicate arial vehicles initially produced from a mixture of expanded polystyrene and polyethylene. The material choice stems from PLA’s non-toxicity, ease of fabrication, and cost-effectiveness. Alongside ordinary PLA, this study includes lightweight PLA to investigate the mechanical performance of this advanced material, which changes its density depending on the printing temperature. This proof-of-concept study explores the mechanical properties of printed parts of the wing prototype. It also considers the possibility of fragmentation in fabricated objects because of the limitations of printing space. The simplified bending tests identified significant reserves in the mechanical performance regarding the theoretical resistance of the material in the wing prototype, which proves the raised hypothesis and delivers the object for further optimization. Focusing on the mechanical resistance, this study ignored rheology and durability issues, which require additional investigations. Fabricating the wing of the exact geometry reveals acceptable precision of the 3D printing processes but highlights the problematic technology issues requiring further resolution.
Bio-Epoxy Resins Based on Lignin and Tannic Acids as Wood Adhesives—Characterization and Bonding Properties
Authors: Gavrilović-Grmuša Ivana , Rančić Milica , Tešić Tamara , Stupar Stevan , Milošević Milena , Gržetić Jelena
Published: September 2024

The possibility of producing and designing bio-epoxides based on the natural polyphenol lignin/epoxidized lignin and tannic acids for application as wood adhesives is presented in this work. Lignin and tannic acids contain numerous reactive hydroxyl phenolic moieties capable of being efficiently involved in the reaction with commercial epoxy resins as a substitute for commercial, non-environmentally friendly, toxic amine-based hardeners. Furthermore, lignin was epoxidized in order to obtain an epoxy lignin that can be a replacement for diglycidyl ether bisphenol A (DGEBA). Cross-linking of bio-epoxy epoxides was investigated via FTIR spectroscopy and their prospects for wood adhesive application were evaluated. This study determined that the curing reaction of epoxy resin can be conducted using lignin/epoxy lignin or tannic acid. Tensile shear strength testing results showed that lignin and tannic acid can effectively replace amine hardeners in epoxy resins. Examination of the failure of the samples showed that all samples had a 100% fracture through the wood. All samples of bio-epoxy adhesives displayed significant tensile shear strength in the range of 5.84–10.87 MPa. This study presents an innovative approach to creating novel cross-linked networks of eco-friendly and high-performance wood bio-adhesives.
Recent Applications of PLGA in Drug Delivery Systems
Authors: Yang Jie , Zeng Huiying , Luo Yusheng , Chen Ying , Wang Miao , Wu Chuanbin , Hu Ping
Published: September 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.
Constitutive Model for Thermal-Oxygen-Aged EPDM Rubber Based on the Arrhenius Law
Authors: Hu Xiaoling , Yang Xing , Jiang Xi , Song Kui
Published: September 2024

Ethylene-propylene-diene monomer (EPDM) is a key engineering material; its mechanical characterization is important for the safe use of the material. In this paper, the coupled effects of thermal degradation temperature and time on the tensile mechanical behavior of EPDM rubber were investigated. The tensile stress-strain curves of the aged and unaged EPDM rubber show strong nonlinearity, demonstrating especially rapid stiffening as the strain increases under small deformation. The popular Mooney–Rivlin and Ogden (N = 3) models were chosen to fit the test data, and the results indicate that neither of the classical models can accurately describe the tensile mechanical behavior of this rubber. Six hyperelastic constitutive models, which are excellent for rubber with highly nonlinearity, were employed, and their abilities to reproduce the stress-strain curve of the unaged EPDM were assessed. Finally, the Davis–De–Thomas model was found to be an appropriate hyperelastic model for EPDM rubber. A Dakin-type kinetic relationship was employed to describe the relationships between the model parameters and aging temperature and time, and, combined with the Arrhenius law, a thermal aging constitutive model for EPDM rubber was established. The ability of the proposed model was checked by independent testing data. In the moderate strain range of 200%, the errors remained below 10%. The maximum errors of the prediction results at 85 °C for 4 days and 100 °C for 2 and 4 days were computed to be 17.06%, 17.51% and 19.77%, respectively. This work develops a theoretical approach to predicting the mechanical behavior of rubber material that has suffered thermal aging; this approach is helpful in determining the safe long-term use of the material.
Modified Cellulose-Based Waste for Enhanced Adsorption of Selected Heavy Metals from Wastewater
Authors: Trivunac Katarina , Mihajlović Snežana , Vukčević Marija , Maletić Marina , Pejić Biljana , Kalijadis Ana , Perić Grujić Aleksandra
Published: September 2024

Due to industrial growth and its impact on the environment, the increasing amount of industrial waste requires a comprehensive approach aligned with the principles of sustainable development. The main goals are not only to preserve natural resources but also to encourage innovation in the reuse of waste materials. In an attempt to reduce the problems regarding waste disposal and wastewater treatment in the textile industry, fibrous textile waste was used as a starting material to obtain carbon adsorbents for the removal of pollutants from wastewater. Waste cotton and mixed yarns, mainly consisting of polysaccharide cellulose, were hydrothermally carbonized and activated with KOH to convert them into efficient carbon adsorbents for heavy metal removal from water. Characterization of carbonized material showed that after activation, an increase in specific surface area (up to 872 m2/g) and content of surface oxygen groups (6.04 mmol/g) leads to a higher affinity towards heavy metal ions, especially lead ions, and high adsorption capacity of 19.98 mg/g obtained for activated cotton yarns. The results of this research represent a contribution to the reduction of waste materials by modifying them into adsorbents, while the regeneration of adsorbents is an example of the practical application of polysaccharide-based materials in the purification of wastewater containing various heavy metal ions.
Composite Track-Etched Membranes: Synthesis and Multifaced Applications
Authors: Mashentseva Anastassiya A. , Sutekin Duygu S. , Rakisheva Saniya R. , Barsbay Murat
Published: September 2024

Composite track-etched membranes (CTeMs) emerged as a versatile and high-performance class of materials, combining the precise pore structures of traditional track-etched membranes (TeMs) with the enhanced functionalities of integrated nanomaterials. This review provides a comprehensive overview of the synthesis, functionalization, and applications of CTeMs. By incorporating functional phases such as metal nanoparticles and conductive nanostructures, CTeMs exhibit improved performance in various domains. In environmental remediation, CTeMs effectively capture and decompose pollutants, offering both separation and detoxification. In sensor technology, they have the potential to provide high sensitivity and selectivity, essential for accurate detection in medical and environmental applications. For energy storage, CTeMs may be promising in enhancing ion transport, flexibility, and mechanical stability, addressing key issues in battery and supercapacitor performance. Biomedical applications may benefit from the versality of CTeMs, potentially supporting advanced drug delivery systems and tissue engineering scaffolds. Despite their numerous advantages, challenges remain in the fabrication and scalability of CTeMs, requiring sophisticated techniques and meticulous optimization. Future research directions include the development of cost-effective production methods and the exploration of new materials to further enhance the capabilities of CTeMs. This review underscores the transformative potential of CTeMs across various applications and highlights the need for continued innovation to fully realize their benefits.
Influence of Polymer Concentration on the Viscous and (Linear and Non-Linear) Viscoelastic Properties of Hydrolyzed Polyacrylamide Systems in Bulk Shear Field and Porous Media
Authors: Azad Madhar Sahib
Published: September 2024

Enhanced oil recovery (EOR) methods are generally employed in depleted reservoirs to increase the recovery factor beyond that of water flooding. Polymer flooding is one of the major EOR methods. EOR polymer solutions (especially the synthetic ones characterized by flexible chains) that flow through porous media are not only subjected to shearing forces but also extensional deformation, and therefore, they exhibit not only Newtonian and shear thinning behavior but also shear thickening behavior at a certain porous media shear rate/velocity. Shear rheometry has been widely used to characterize the rheological properties of EOR polymer systems. This paper aims to investigate the effect of the polymers’ concentrations, ranging from 25 ppm to 2500 ppm, on the viscous, linear, and non-linear viscoelastic properties of hydrolyzed polyacrylamide (HPAM) in shear field and porous media. The results observed indicate that viscous properties such as Newtonian viscosity increase monotonically with the increase in concentration in both fields. However, linear viscoelastic properties, such as shear characteristic time, were absent for concentrations not critical in both shear rheometry and porous media. Beyond the critical association concentration (CAC), the modified shear thinning index decreases in terms of concentration in both fields, signifying their intensified thinning. At those concentrations higher than CAC, the viscoelastic onset rate remains constant in both fields. In both fields, the shear thickening index, a strict non-linear viscoelastic property, initially increases with concentration and then decreases with concentration, signifying that the polymer chains do not stretch significantly at higher concentrations. Also, another general observation is that the rheological properties of the polymer solutions in both porous media and shear rheometry only follow a similar trend if the concentration is higher than the CAC. At concentrations less than the CAC, the shear and porous media onset rates follow different trends, possibly due to the higher inertial effect in the rheometer.