bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of precession laser machining of microholes in aerospace material
Authors: Le Hoang , Nasrollahi Vahid , Karkantonis Themistoklis , Penchev Pavel , Marimuthu Sundar , Crozier Mickey , Dimov Stefan
Published: February 2023

Sidewall tapering is one of the main limitations in ultrashort pulse (USP) laser machining and is associated with the beam shape and self-limiting effect. Laser processing with a precession beam is a potential solution to overcome this limitation. A study into the effects of precession parameters on the taper angle in microhole drilling of a nickel alloy is reported in this paper. The effects of three key precession parameters, i.e., incident angle, relative distance between the focuses of the precession and individual beams, and scanning speed, have been investigated in detail. Experiments were performed to drill through holes with aspect ratios up to 20:1 and diameters ranging from 100 to 500 μm over 0.6–2 mm thick nickel alloy substrates. Experiment results showed that all the considered parameters/factors were significant and affected the hole tapering in different ways. In addition, there were important interaction effects between two of the factors, i.e., incident angle and focus position, in some cases. The optimal parameters to minimize the tapering effect are suggested, and the mechanism is discussed in detail. The precession laser machining showed clear advantages in overcoming the limitations to associated with conventional USP laser machining. Fabricating microholes with high geometrical accuracy, i.e., with straight side walls and zero taper angles, is feasible with the use of a precession beam. The results clearly show the potential of precession laser processing and the capabilities that the technology can offer for a range of laser micromachining applications in different industries, such as microelectronics, automotive, and aerospace.
Establishment of breast carcinoma cell lines
Authors: Mogilenskikh A. S , Sazonov S. V
Published: February 2023

Obtaining of a primary cell culture of breast carcinoma is necessary both for the study of molecular and cellular mechanisms of tumor growth and for the selection of personalized therapy. However, when obtaining such culture, technical difficulties arise: poor adhesion to the substrate, increased growth of fibroblasts in culture, early aging, and others. The review describes the main options for culturing breast carcinoma cells - two-dimensional cultures, three-dimensional cultures, tissue sections, and also discusses methods for their preparation. The results of studies on changes in the receptor apparatus during cultivation and assessment of the effect of anticancer drugs on breast carcinoma cells in vitro are presented.
Test-system in vitro for screening of therapeutic drugs with IL-17A inhibitory activity
Authors: Ossina N. K , Pugachev E. I , Kolyadenko I. A , Pryazhkina V. V , Shakurov E. G , Orlov E. V , Volova L. T
Published: February 2023

To achieve greater clinical relevance of the newly discovered compounds, modern drug discovery requires disease-targeted assays based on human cells. The specific aim of this study was to design and develop a new cell-based assay for screening of compounds with IL-17A inhibitory activity. Human foreskin fibroblasts (HFF) were treated with IL-17A alone (experimental conditions I) or a mixture of IL-17A inhibitor netakimab and IL-17A (experimental conditions II). IL-17A - dependent production of inflammatory mediators IL-6, IL-8, MCP-1 was evaluated by ELISA (enzyme-linked immunosorbent assay). The study demonstrated the ability of HFF subcultured in vitro for a long time (>20 passages) to respond to IL-17A treatment by increased production of inflammatory cytokines IL-6, IL-8, MCP-1. Neutralization of IL-17A by netakimab (IL-17A inhibitor) resulted in a dose-dependent decrease of inflammatory cytokines production into cell growth medium. Thus, a new cell-based assay to evaluate the biological activity of Il-17A inhibitors has been developed and tested. The assay is based on the analysis of IL-17A-dependent production of inflammatory cytokines synthesized by human dermal fibroblasts. Netakimab has been shown to be a highly potent inhibitor of IL-17A.
Biogenesis and secretory pathways of mast cell chymase: structural and functional aspects
Authors: Atiakshin D. A , Klochkova S. V , Shishkina V. V , Nikityuk D. B , Alekseeva N. T , Kostin A. A
Published: February 2023

Chymase is a specific protease of mast cells (MC) with variable expression and is one of the preformed components of the secre-tome. Chymase biogenesis begins with the processes of transcription in the nucleus, continuing in the cytoplasm of MC on ribosomes and in the cisterna of the endoplasmic reticulum. Entering the Golgi complex, molecules of the prochymase undergo post-translational modifications, this continuing in the vesicles detached from trans Golgi network. During further processing under granules maturation, chymase becomes an active enzyme and undergoes in-tragranular accumulation with typical topographic regularities, determining the features of the cytological and ultrastructural phenotype of MC. Various secretory mechanisms of chymase excretion into the extracellular matrix result in the development of diverse biological effects due to high selectivity of the protease to the molecular targets of cellular and extracellular components of the specific tissue microenvironment. Since chymase is an important enzyme in the formation of the state of the integrative-buffer metabolic environment of connective tissue, it is advisable to consider it as a diagnostic marker and a probable pharmacological target in the treatment of a number of pathological conditions. The involvement of chymase in the mechanisms of inflammation and allergy, angiogenesis and oncogenesis, remodeling of the extracellular matrix of connective tissue and changes in the histoarchitectonics of organs is also known. The technology of immunohistochemical staining using chro-mogenic or fluorescence detection allows objectively determining the number of chymase-positive MCs in the intraorgan population, the mechanisms of biogenesis and processing, cyto- and histoto-pographic characteristics with visualization of secretory pathways. Thus, the morphological identification of chymase significantly expands the interpretation of the data obtained in the study of adaptive and pathological states of internal organs, claiming not only diagnostic value, but also an assessment of the therapy performed.
Cells corresponding to telocites have been detected in pathologically altered skeletal muscle
Authors: Chekmareva I. A , Deev R. V , Chernova O. N , Bikhteev I. U , Emelin A. M
Published: February 2023

A relatively recently described population of cells, apparently belonging to the tissue system of the internal environment, are the telocytes. Their peculiarities are not only the co-expression of CD117- and CD34-molecules, but also thin, indistinguishable processes at the light-optical level, whose length can be many times greater than the diameter of the cell body. In this regard, transmission electron microscopy remains the method of choice for their detection in tissues. Telocytes were found in the myocardium, connective tissue of the gallbladder, in gastrointestinal tract, in the stroma of the exocrine glands, the placenta, some vessels. However, data on the detection of telocytes in striated skeletal muscle tissue are either absent or still rare. This brief report demonstrates cells that, by their ultrastructural characteristics, can be identified as telocytes in the endomysium of gastrocnemius muscle in Bla/J mice (mutation in the dysferlin gene, DYSF).
Peran Pendidikan Ekonomi dalam Membentuk Ekspektasi Masa Depan Keluarga Terhadap Pendidikan
Authors:   Universitas Negeri Makassar, Indriani Novianti , Hasan Muhammad , Inanna Inanna
Published: February 2023

Family is the first place for children to get an education. Person parents act as educators in the family so that their daily attitude and actions days provide a stimulus to the child’s behaviour. Economic education in a family environment given by parents provides understanding and application of economic concept for children. The existence of financial education in the family is expected to be able to improve the family economy. This study contains how economic education is crucial to be taught and instilled in children to become individuals who behave economically in a rational, independent, and care for others. The research method used is the research method qualitative descriptive in a literature study with data sources derived from books or existing literature. This study indicates that attitudes and the behaviour that the child forms will influence their mindset deeply arrange and design its future.
Perencanaan Sistem Loop Jaringan 20 kV Menggunakan Load Breaking Switch Motorized di Penyulang Sawit, Jati dan Pala
Authors: Fitriono Fitriono , D Dasweptia , H Hamimi
Published: February 2023

ABSTRAK

Perencanaan Sistem Loop Jaringan 20 kV Menggunakan LBS (Load Breaking Switch Motorized) di PenyulangSawit, Jati dan Pala. Program Studi Teknik Elektro Fakultas Teknik Universitas Muhammadiyah Lampung.

Setiap jaringan tegangan menengah 20 kV termasuk jaringan penyulang Sawit, Jati dan Pala pasti akan mengalami pemadaman untuk proses pemeliharaan secara berkala, selain itu dengan kondisi jaringan yang relatif panjang yaitu penyulang Sawit 78,4 KMS, penyulang Jati 45,8 KMS dan penyulang Pala 130,1 KMS maka potensi akan terjadi gangguan pada jaringan penyulang Sawit, Jati dan Pala cukup tinggi. Berdasarkan kondisi pemeliharaan dan potensi gangguan yang akan terjadi serta konfigurasi jaringan eksisting yang tidak memungkinkan untuk dimanuver maka penyaluran energi listrik ke pelanggan menjadi tidak handal.

Untuk mendapatkan jaringan tegangan menengah yang handal tentunya perlu dilakukan analisis, evaluasi dan simulasi kehandalan jaringan dalam menghadapi kondisi-kondisi pemeliharaan dan gangguan. Karena tingginya ENS (Energy Not Supplied) yang ditimbulkan pada simulasi kondisi eksisting maka dilakukan perencanaan pemasangan LBSM pada titik manuver penyulang atau titik pertemuan penyulang yaitu LBSM Dono Mulyo (pertemuan penyulang Sawit dan Pala) dan LBSM BD 8 (pertemuan penyulang Jati dan Pala), selain itu untuk mempercepat waktu pengusutan gangguan maka juga dilakukan resetting dan pengaktifan fungsi sectionalizer pada LBSM yang menjadi pembatas setiap section di penyulang.
Desain Pump Storage Power Plant (PSPP) dari Pembangkit Tenaga Surya dengan Studi Kasus Embung ITERA
Authors: Corio Dean
Published: February 2023

Pump Storage Power Plant (PSPP) merupakan alternatif penyimpanan energi potensial yang dimanfaatkan kembali sesuai dengan kebutuhan. Aplikasinya dapat dilakukan pada waduk atau reservoir yang lebih tinggi dengan inputan air waduk yang lebih rendah ataupun sumber lain. Disain PSPP disesuaikan dengan kapasitas upper reservoir, daya desain dan waktu pembangkitan. Pompa untuk menaikkan air dari lower reservoir dapat dihidupkan menggunakan sumber energi terbarukan berupa Photo Voltaic (PV). Keluaran PV tetap disimpan di baterai untuk mendapatkan tegangan dan arus yang stabil sebagai input pompa. Rancangan PSPP pada Embung ITERA memiliki effisiensi pembangkitan 80 persen, sedangkan effisiensi PV sebesar 87 persen.
Sistem Informasi Berbasis Web Untuk Memonitoring Perangkat Internet of Things (IoT) Menggunakan Node-Red
Authors: Mulyawan M Fikri , Batubara Mona Arif Muda , Pradipta Rio Ariestia
Published: February 2023

Information systems in monitoring Internet of Things (IoT) devices in this advanced telecommunications world are very important, where we can see in real-time the data displayed by the device. This is very useful in improving the performance and efficiency of the development party. The use of this technology makes it easier to anticipate error that occurs to system Internet of Things (IoT) devices. By being displayed using a dashboard, it makes it easier for users to read data provided by the Internet of Things devices.

In this study, the author develops a Dashboard information system for the Internet of Things Device system. Data from the system will be sent to a database which will then be displayed using the Node-Red tools. This tool is a middleware that connects the Internet of Things (IoT) devices with a database, the results of reading the Internet of Things system will be stored in the database and the results can be seen through the Dashboard in real-time. The result of the measurement if it exceeds the standard limit that has been determined, will give an alert in the form of a notification in the Email.
Character Changes Related to Sports Participation and Contextual Factors Among Secondary School Students
Authors: Mwenda Peninah Wanjiku , Rintaugu Elijah Gitonga , Mwangi Francis Mundia
Published: February 2023

Sports participation is hailed as one of the effective ways of nurturing positive character among the youth. However, some studies have also indicated that sports may lead to undesirable behavior when conducted under certain uncontrolled conditions. The purpose of this study was to assess the influence of selected contextual factors on character changes related to sports participation among secondary school students. The study focused on level of sports participation, gender, age, type of sport, school category, school status, school type, and class level of students as independent variables with potential to influence character changes related to sports participation. A Quasi-experimental research design was utilized, with the dependent variable of character traits assessed at the pre and post three months competitive games season. Purposive sampling was used to select 336 student-athletes from 24 (9.3%) of secondary schools in Nairobi city county. A close-ended questionnaire on character which was adapted from Individual and Team Character in Sport Questionnaire (ITCSQ) and Arizona Sport Summit Accord (ASSA) was utilized for data collection at the pre-and posttests. Matched Sample Wilcoxon Signed Rank test showed significant negative change in honest /integrity character component scores between pre-test and post-test (p=0.006). Multinomial Logistic Regression Analyses showed that boarding status, school category and type of sport can significantly (p<0.05) influence character changes among competitive student-athletes. Therefore it is concluded that boarding status, school category and type of sport can influence outcomes of sports experiences leading to positive or negative character change. It is therefore recommended that curriculum developers and implementers should consider contextual factors to optimize sports experiences and outcomes to promote desirable character changes and development.
Pendidikan Karakter Anak Usia Dini untuk Melatih Kendirian Melalui Bermain Bahan Alam
Authors: Prifiantari Siska
Published: February 2023

The decline in the morals of the millennial generation, an era that is increasingly rampant with technological sophistication in the era of globalization has made a retreat in the moral quality of life of the Indonesian people today, especially among students and demands character education.  This research uses the library research method. Data collection techniques are obtained from 11 kinds of journal articles related to the topic of discussion. It is very important to form the character of the child from an early age. A strong identity and character really need a systematic and well-organized coaching program. Child character education is not only carried out by the teacher, but the main task of parents is also to implement the child's character education at home. In carrying out character education, parents and teachers are role models to imitate and follow. Independence is the ability of the child to do everything independently, both related to his own activities and in everyday life, without being completely dependent on others. With the attitude of independence that the child has provides enormous benefits for himself including, 1) Children can move more freely to learn and interact with the surrounding environment; 2) Make them more confident and make things free; 3) Children are easy to play and interact well; 4) Easy to work and communicate with the child
Pengembangan Multimedia Pembelajaran Pada Mata Pelajaran PKN Kelas X di SMAN 6 Padang
Authors: Cantika Hasa , Zuwirna Zuwirna , Syafril Syafril , Eldarni Eldarni
Published: February 2023

Penelitian Pengembangan Multimedia Pembelajaran pada mata pelajaran PKN Kelas X di SMA 6 Padang yang dilatar belakangi karena siswa kurang tertarik untuk belajar PKN, guru mata pelajaran yang masih kurang optimal dalam penggunaan media pembelajaran. Penelitian ini bertujuan untuk mengembangkan produk multimedia menggunakan aplikasi Lectora Inspire pada mata pelajaran PKN kelas X SMA, dan mengetahui prosedur pengembangan multimedia pembelajaran yang dikembangkan layak atau tidak digunakan dalam proses pembelajaran oleh guru dan peserta didik. Jenis penelitian iyang idigunakan dalam penelitian ini yaitu penelitian dan pengembangan yang disebut dengan istilah Research and Development(R&D) menggunakan model ADDIE. Pada model iini ada 5 tahap pengembangan yaitu tahap Analisis (Analysis), tahap Perancangan (Design), tahap Pengembangan (Development), tahap Penerapan (Implementation), dan tahap Evaluasi (Evaluation). Uji validitas dilakukan kepada 3 iorang yaitu 2 validator media dan 1 validator materi. Uji praktikalitas dilakukan kepada 30 responden yaitu peserta didik kelas X PKN di SMA Negeri 6 iPadang. Data dianalisis secara deskriptif kuantitatif dengan mengakulasi persentase dari setiap sub variabel. Berdasarkan hasil penilaian oleh kedua validator media memperoleh skor rata-rata sebesar 4,78 yang dikategorikan “sangat ivalid”. Hasil validasi penilaian dari validator materi memperoleh rata-rata sebesar 4,8 iyang dikategorikan “sangat ivalid”. Hasi uji praktikalitas produk oleh peserta didik memperoleh rata-rata sebesar 4,42 yang dikategorikan “praktis”. Berdasarkan hasil penilaian validitas dan praktikalitas produk maka dapat disimpulkan bahwa produk sudah memenuhi syarat sebagai media yang layak digunakan dalam proses pembelajaran PKN.
Pelaksanaan Pendidikan Karakter di SMPN 3 Pariaman
Authors: Oktavia Aini Anisa , Eldarni Eldarni
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan pendidikan karakter di SMPN 3 Pariaman serta mengetahui kendala-kendala dan upaya yang dilakukan guru dalam pelaksanaan pendidikan karakter. Pendidikan karakter yang dibangun dalam kegiatan sekolah merupakan salah satu program strategis yang diharapkan dapat mengatasi berbagai permasalahan yang berkaitan dengan moral siswa. Jenis penelitian ini menggunakan penelitian kuantitatif deskriptif. Populasi yang diambil adalah guru SMPN 3 Pariaman. Sampel penelitiannya sebanyak 45 guru. Instrumen pengumpulan data menggunakan angket (kuisioner). Hasil penelitian dianalisis menggunakan presesentase. Penelitian menyimpulkan bahwa: (1) pelaksanaan pendidikan karakter di SMPN 3 Pariaman sudah dilaksanakan dengan kategori “Sangat Baik” dengan hasil rata-rata 91,20%; (2) kendala-kendala dalam pelaksanaan pendidikan karakter berada pada kategori “Tinggi” dengan rata-rata 71,38%; (3) upaya yang dilakukan guru untuk mengatasi hambatan tersebut berada pada kategori “Sangat Baik” dengan rata-rata 85,78%
Pembuatan Modul Gambar Teknik Listrik Berbasis Autocad di Sekolah Menengah Kejuruan
Authors: Azura M. Ronald , Hambali Hambali
Published: February 2023

Electrical Engineering Drawing is one of the compulsory subjects that must be studied for students. In the implementation of learning at SMK N 2 Kota Sungai Kunci this subject is still done manually, namely by using pencils and drawing paper. However, with the empowerment of computer labor, it can carry out the learning process of Electrical Engineering Drawings with the help of Autocad software. Therefore, it is necessary to make an Electrical Engineering Drawing learning module to support students in understanding the use of software in understanding material. This study aims to determine the validity and feasibility of the Autocad-based Electrical Engineering Drawing module at SMK N 2 Kota Sungai Lilin. Based on the results of the research that has been done, data is obtained from a questionnaire analysis by a validator consisting of 2 material experts and media experts. The results of the validity test of the Autocad-based Electrical Engineering Drawing learning module assessed by the material expert validator obtained a very high validity category while the media expert validator obtained a very high validity category. The results of the due diligence conducted by 34 class X students of the Department of Electrical Power Installation Engineering obtained a very decent category. So, the conclusion from this study is that the Autocad-Based Electrical Engineering Drawing module is feasible to be used in the learning process of Electrical Engineering Drawings for class X of the Electrical Engineering Department.
Persepsi Siswa Vokasi terhadap Perencanaan, Pelaksanaan dan Evaluasi Pembelajaran Kerja Bengkel dan Gambar Teknik
Authors: Dora Sonia , Efendi Hansi
Published: February 2023

Based on the observations made, the learning process at SMK Negeri 1 Ranah Batahan is not in accordance with the subjects and student characteristics. Often student learning outcomes do not meet the minimum standard of completeness for practicum subjects and technical drawing. Many teachers, including vocational teachers, complain of difficulties in implementing the 2013 curriculum. The learning process needs to be updated so that students do not only receive information from their teachers, but also actively participate in finding information, data, and the knowledge they want to learn. For this reason, the teacher as a facilitator and motivator to optimize student learning should choose the right strategy to increase students' willingness to learn. For this reason, it is necessary to look at student responses regarding the planning, implementation and evaluation of workshop work subjects and technical drawings at SMKN 1 Ranah Batahan. Based on the results of the study, it was concluded that the students' opinions on planning, implementation of learning for Workshop Work Subjects and Technical Drawings of Class X Audio Video Engineering Skills Packages at SMK N 1 Ranah Batahan described the respondent's achievement level of 86.30% in the good category. As well as students' responses to the Evaluation of Subjects for Workshop Work and Technical Drawing Subjects with the respondent's achievement level of 87.11% in the good category.
Implementation of Halal Financing Principles (Murabahah) at BPR Al Ashri Jember
Authors: Miftakhul Jannah  , Farida Umi Choiriyah
Published: February 2023

This essay aims to identify the application of syariah principles carried out by BPR, namely BPR Al Ashri Jember. The current issue is about legal financing products, namely murabaha financing, especially in Islamic financial institutions that deviate from syariah principles. This study uses exploratory research methods, using interviews to collect data from BPR Al Asri customers. The results of this study indicated that the murabahah contract process is viewed from 1. The legality of the purchased goods 2. the agreement on the amount of financing between the customer with the BPR 3. the purchase of goods by the BPR and the power of attorney for the customer if buying the goods themselves.4. the acquisition price of the goods 5. the agreement in determining margin acquisition 6. The report of goods specifications 7. down payment status when there is a cancellation of the purchase of goods 8. guarantee in murabahah financing. From the several things above, it can shows regarding the process of financing customers, indicating that BPR Al Asri has implemented murabahah financing based on syariah principles
Creative Economy Development Strategy In Banyumas Regency
Authors: Sidik Rohiwan
Published: February 2023

The creative economy is a sector that has great opportunities to develop and make an economic contribution to the people of Banyumas Regency. This study aims to identify the strengths, weaknesses, opportunities and threats as a basis for planning the development of a creative economy in Banyumas Regency. The research was conducted using a qualitative method with a literature study approach. The results of the research show that the role of the creative economy community is very important in terms of public policy and has considerable strengths as well as opportunities.
AN INSIGHT DATA ON MEDICATION SAFETY IN ACCORDANCE WITH DRUG COMPLICATIONS BASED ON THE AUTOMATED DISPENSING SYSTEM
Authors:   Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, (U.P), India 226001, CHAUDHARY NANDINI , YADAV BINDU SINGH ,   Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, (U.P), India 226001, KUMAR RAJNEESH ,   Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, (U.P), India 226001, SINORIA ARTI ,   Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, (U.P), India 226001, GUPTA AMRESH ,   Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, (U.P), India 226001
Published: February 2023

Automated dispensing systems have been applied for maintaining medication safety, improving drug distribution, and reducing the risk of medication errors in different pharmacy practice. Automated dispensing machines maintain the balance of accessibility, stock control of medications, and protection which were the main features of a safe medication distribution system. It should be linked with medication review and regular patient counselling. Encourage the timely administration of drugs through expanding their access to patient care units and first-dose availability was improved in automated dispensing machines. Physicians allow treatment efficiently by providing convenient access to medications of critically ill patients for emergencies during and after pharmacy hours with automated dispensing machines. This investigation demonstrates that the nature of pharmacotherapy for patients with automated dose dispensing can be improved. This study highlights the impact of an automated dispensing system in primary healthcare, Automated Dispensing Cabinets, or, in an intensive care unit to reduce medication errors. Implementation of automated dispensing systems reduces dispensing errors and gives pharmacists more time to review patient profiles. It recommends that every patient with automatic dose dispensing ought to go through a careful medication review through prescribers and pharmacists. It concluded that the automatic drug dispensing focuses on the effect of a medication review in patients. The ideal recurrence for conducting medication reviews and follow-up will likely contrast between individual patients. Hence, it provides an insight data on medication safety based on the automated dispensing system in accordance with drug complications. KEYWORDS: Automated dose dispensing, Medication safety, Drug complication, Impact, Evaluation, Insight report on medication safety
IN VITRO EVALUATION OF SOME BRANDS OF DICLOFENAC SODIUM INJECTION MARKETED IN GREATER NOIDA, UTTAR PRADESH, INDIA USING UV-VIS SPECTROPHOTOMETRIC METHOD
Authors:   Department of Pharmaceutical Chemistry, School of Science, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, (U.K), India 246174, GHOSAL PRADYUMNA , S SHIVANI ,   Department of Pharmaceutical Chemistry, School of Science, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal, (U.K), India 246174
Published: February 2023

Quality is of principal subject to human beings in all perspective of life. When it comes to the quality of the pharmaceuticals which are consumed by humans, it is of most extreme significant as they are utilized for the prosperity of the humanity. In this study our objective was to evaluate the experimental in vitro study of the commercially obtainable Diclofenac Sodium injection brands which are available in Greater Noida. Ten different ampoules of 75mg/3ml diclofenac sodium injection products randomly collected from retail pharmacies and Govt. Hospital of targeted area in Greater Noida, Uttar Pradesh, India, twenty ampoules 75 mg/3ml have the same batch number of each brand were collected for the analysis. All the analytical methods were done in the quality control laboratories of JBJM Parenteral Pvt Ltd, Greater Noida, Uttar Pradesh, India. The study was carried out by performing various tests which is affiliated with the quality such asgeneral appearance of Diclofenac Sodium injection ampoule, Particulate matter, Average fill volume, pH and content assay through pH Meter (Spectra lab), UV-Vis Spectrophotometer (UV-1900i SHIMADZU). The assay was evaluated by UV-Vis Spectrophotometer at the wavelength of 276nm. The results show that diclofenac sodium injection following IP specification, it can be concluded that all of the 10 brands of the drug passed through UV-Vis spectroscopy method also in pH meter. The Spectroscopy method was successfully applied to evaluate of Diclofenac Sodium injection. KEYWORDS: In vitro evaluation, Diclofenac sodium injection, UV-Vis Spectroscopy, pH, Analytical method, Pharmaceutical analysis, SHIMADZU, Greater Noida, Spectroscopy, Quality evaluation
Russian Diplomat Vasily Nikitin and Polish Oriental Studies. Nikitin’s letters to Professor Tadeusz Kowalski
Authors: Kończak Izabela
Published: February 2023

Vasily Nikitin (1.1.1885–6.6.1960) – a former Russian consul in Urmia, Iranian studies researcher and Kurdologist – corresponded with professor Tadeusz Kowalski for over a quarter of a century. His letters sent to Krakow in the years 1922–1948 are held in the Archives of the Polish Academy of Sciences (PAN) and Polish Academy of Arts and Sciences (PAU). The aim of this article is to present the relationship of Vasily Nikitin with Polish Oriental studies and Orientalists on the basis of an analysis of the letters sent by him to Tadeusz Kowalski. The correspondence changed during this time. At the beginning, Nikitin sought help from Kowalski in finding a job at the Jagiellonian University. With time, when his financial situation in Paris – where he was in exile – stabilized, he was interested in working with Polish Orientalists at a distance. Due to Kowalski’s efforts, Nikitin became a foreign member of the Polish Oriental Society and the PAU’s Oriental Commission. Thanks to this, he received publications issued by these organizations. He also published in the oldest Polish Oriental journal – the Yearbook of Oriental Studies (Rocznik Orientalistyczny) – and in other journals.
Jan Grzegorzewski – Visionary Orientalist or “Dreamer and Dilettante”?
Authors: Siemieniec-Gołaś Ewa
Published: February 2023

17 November 2022 marks the centenary of the death of Jan Grzegorzewski – Orientalist, Slavist, publicist and social activist. The aim of this article is to highlight this figure and to show his activity in various areas of social and scientific life, especially his contribution to Polish Oriental studies. This somewhat forgotten but extremely interesting and colourful, although somewhat controversial, figure has still not received the comprehensive biographical treatment he fully deserves. Thanks to his extraordinary determination and commitment to his activities, Jan Grzegorzewski initiated the establishing of the first Polish scientific journal of Oriental studies, Rocznik Orientalistyczny, for which he also obtained funds. The first part of the first volume of Rocznik, covering the years 1914–1915, was published in 1915 in Cracow, and the second part (for the years 1916–1918) only in 1918. There is also no doubt that with his activities, both academic and journalistic, Jan Grzegorzewski contributed to the establishment of the first Polish Oriental studies in Poland, which took place in 1919 at the Jagiellonian University in Cracow. Analysing some of Grzegorzewski’s achievements from today’s perspective, one can venture to say that with the issues presented in his publications, he undoubtedly inspired many later Orientalists to set new research directions.
ANALISIS PEMBELAJARAN BIOLOGI SMA/MA DI JABODETABEK DITINJAU DARI STANDAR PROSES
Authors: Fadlilah Dina Rahma , Herlanti Yanti
Published: February 2023

Penelitian ini bertujuan untuk menganalisis pendekatan saintifik sebagai implementasi Standar Proses pada pembelajaran Biologi. Implementasi Standar Proses yang baik merupakan salah satu upaya untuk meningkatkan mutu proses pembelajaran. Dalam Permendikbudristek No. 16 Tahun 2022 tentang Standar Proses, disebutkan bahwa pelaksanaan pembelajaran diselenggarakan dalam suasana belajar yang interaktif, inspiratif, menyenangkan, menantang, dan memotivasi peserta didik. Pembelajaran yang demikian sebetulnya mulai diinisiasi dalam Kurikulum 2013 melalui pendekatan saintifik yang menyarankan beberapa model pembelajaran, yaitu discovery/inquiry learning dan pembelajaran berbasis masalah, meliputi problem-based learning (PBL) dan project-based learning (PjBL). Pendekatan yang digunakan dalam penelitian adalah kuantitatif dan kualitatif. Berdasarkan hasil penelitian, ditunjukkan bahwa implementasi pendekatan saintifik telah dilaksanakan oleh para guru di kelas. Namun, persepsi peserta didik menunjukkan hasil sebaliknya, di mana guru masih kurang menerapkan aktivitas secara “hands on” melalui pendekatan saintifik. Pelaksanaan Standar Proses yang telah berjalan baik dari Kurikulum 2013 layak dipertahankan pada Kurikulum Merdeka, karena masih sejalan dengan tujuan kurikulum yang baru. Diharapkan kekurangan yang ditemukan pada penelitian ini dapat diatasi sehingga implementasi pada Kurikulum Merdeka dapat lebih baik lagi.
PERAN ORANG TUA DALAM PENDIDIKAN KARAKTER UNTUK MENCEGAH PERILAKU MENYIMPANG PADA REMAJA
Authors: Mulati Yeni
Published: February 2023

Berdasarkan komposisi usia penduduk saat ini, Indonesia akan mendapatkan bonus demografi pada tahun 2030 hingga 2040. Namun, fenomena penyimpangan pada remaja, seperti aksi klitih, penyalahgunaan narkoba, cyberbullying, pergaulan bebas, dan sebagainya, dikhawatirkan akan menjadi masalah tersendiri di kemudian hari. Orang tua merupakan salah satu agen yang sangat penting dalam pembentukan karakter-karakter positif bagi remaja. Oleh karena itu, artikel ini akan mencoba membedah hal-hal apa yang bisa dijalankan para orang tua untuk menguatkan karakter para remaja dan menghindarkan mereka dari perilaku menyimpang atau kenakalan remaja. Metode yang digunakan adalah literature review atau kajian pustaka. Dari hasil kajian pustaka diketahui bahwa peran yang perlu dilakukan orang tua adalah mengusahakan agar remaja bisa memenuhi tugas-tugas perkembangannya, memahami psikologi remaja, dan menjadi role model yang baik untuk remaja. Selain itu, mereka juga harus mengembangkan 3 dimensi karakter, yaitu moral knowing, moral feeling, dan moral action. Di samping itu, orang tua perlu menerapkan pola asuh yang tepat sesuai dengan kebutuhan anak. Untuk mengoptimalkan potensi anak, orang tua bisa menerapkan pendidikan di dalam rumah dengan pendekatan kecerdasan majemuk. Kerja sama orang tua dengan berbagai pihak, khususnya sekolah, sangat diperlukan agar upaya-upaya tersebut berjalan dengan efektif.
PERBEDAAN MOTIVASI BELAJAR MATEMATIKA SISWA SETELAH MENGGUNAKAN STRATEGI PEMBELAJARAN QUICK ON THE DRAW
Authors: Huriyanti Luthfi , Rosiyanti Hastri
Published: February 2023

Penelitian ini bertujuan untuk mengetahui perbedaan motivasi belajar matematika siswa sebelum dan sesudah diterapkannya strategi pembelajaran quick on the draw. Penelitian ini dilakukan menggunakan metode pre-eksperimental design dengan desain penelitian yaitu one-group pretest-posttest design. Teknik pengambilan sampel menggunakan purposive sampling. Populasi dalam penelitian ini adalah seluruh siswa kelas VII MTs Negeri 1 Kota Bekasi sebanyak 429 siswa dengan sampel seluruh siswa kelas VII-3 sebanyak 43 siswa. Hasil uji validitas dan reliabilitas menghasilkan 26 soal yang valid dan reliabel. Hasil angket motivasi belajar matematika yang berupa data ordinal terlebih dahulu ditransformasikan menjadi data interval menggunakan MSI (Methode of Successive Interval). Uji hipotesis dihitung dari skor pretest dan posttest angket motivasi belajar matematika dengan menggunakan uji-t sampel tak bebas dan dihasilkan t0 = 2,398 dan ttabel= 2,021 yang berarti terdapat perbedaan motivasi belajar matematika siswa sebelum dan sesudah diterapkannya strategi pembelajaran quick on the draw.
KEMAMPUAN KONEKSI MATEMATIS SISWA PADA MODEL PEMBELAJARAN CONNETED MATHEMATICS PROJECT (CMP)
Authors: Puteri Junike Wulandari , Riwayati Selvi
Published: February 2023

Tujuan penelitian ini mengetahui apakah ada perbedaan kemampuan koneksi matematis siswa menggunakan model pembelajaran CMP dan pembelajaran konvensional. Salah satu tujuan matematika adalah kemampuan menjelaskan keterkaitan antar konsep matematika. Oleh karena itu, kemampuan koneksi matematis peting dalam proses pembelajaran. Salah satu alternatif model pembelajaran untuk menumbuh kembangkan kemampuan koneksi matematis siswa adalah dengan memilih model pembelajaran CMP. Pada proses pembelajaran CMP  dilakukan dengan berkelompok dimana siswa akan dituntut untuk bisa menghubungkan materi yang sudah di pelajari dengan materi yang akan dipelajari. Jenis penelitian ini adalah penelitian eksperimen semu. Adapun populasi dalam penelitian ini adalah semua siswa kelas VIII SMP N 15 Kota Bengkulu yang terdiri dari 5 kelas.  Setelah diambil secara acak terpilih kelas VIII D sebagai kelas kontrol dan VIII E sebagai kelas eksprimen. Instrument penelitian ini adalah tes kemampuan koneksi matematis berupa pretest-posttest dalam bentuk soal uraian. Dalam penelitian ini teknik analisis data menggunakan uji t. Hasil penelitian menunjukkan bahwa kemampuan koneksi matematis siswa yang diajar   menggunakan model pembelajaran CMP lebih baik dibandingkan dengan pembelajaran konvensional.
ANALISIS KINERJA MAHASISWA PENDIDIKAN MATEMATIKA DALAM PENGAJARAN MIKRO SEKOLAH DASAR
Authors: Dirgantoro Kurnia Putri Sepdikasari
Published: February 2023

FIP UPH mengharapkan mahasiswa calon guru matematika yang menenpuh pendidikan di UPH dapat mengajar baik di tingkat sekolah menengah maupun di tingkat sekolah dasar. Oleh sebab itu mahasiswa dianjurkan untuk mengambil mata kuliah yang memuat pengajaran mikro matematika sekolah dasar sekalipun tidak ada mata kuliah mengenai materi matematika sekolah dasar yang disediakan. Penelitian ini merupakan penelitian kualitatif deskriptif untuk melihat sejauh mana kinerja mahasiswa pendidikan matematika dalam pengajaran mikro matematika sekolah dasar. Penelitian ini diharapkan dapat menjadi masukan dan perbaikan bagi pelaksanaan pengajaran mikro yang telah berlangsung, juga masukan bagi mahasiswa calon guru untuk terus meningkatkan keterampilan dasar mengajar. Adapun dalam penelitian ini, subjek yang diteliti adalah 56 mahasiswa program studi pendidikan matematika FIP UPH. Instrumen yang digunakan adalah rubrik penilaian pengajaran mikro dan kuesioner terbuka. Adapun hasil penelitian ini adalah mahasiswa calon guru matematika sudah cukup baik dalam melakukan pengajaran mikro, namun masih harus terus meningkatkan keterampilan dasar mengajar, khususnya dalam keterampilan pengelolaan kelas. Hasil lainnya adalah sebagian besar mahasiswa telah menyadari kegunaan pengajaran mikro dalam meningkatkan kemampuan mengajar mereka, walaupun mereka masih menemukan beberapa kendala/kesulitan.
SEMIGRUP SMARANDACHE (L_D (V,W),Θ)
Authors: Rahmawati Miftah Sigit
Published: February 2023

Semigrup merupakan struktur aljabar yang merupakan perumuman dari grup. Suatu semigrup yang memuat suatu subset sejati sedemikian hingga subset tersebut merupakan grup terhadap operasi biner yang sama pada semigrup disebut semigrup Smarandache. Himpunan semua transformasi linear dari suatu ruang vektor V ke ruang vektor V, yaitu LD(V) terhadap operasi komposisi transformasi linear membentuk suatu semigrup. Apabila diberikan himpunan transformasi linear dari suatu ruang vektor V  ke ruang vektor W, yaitu LD(V,W) maka LD(V,W) bukan merupakan semigrup terhadap operasi komposisi transformasi linear. Himpunan transformasi linear LD(V,W) dapat menjadi suatu semigrup terhadap operasi komposisi transformasi linear dengan membantuk semigrup transformasi linear yang diperumum. Dalam tulisan ini akan dibahas mengenai regularitas dan unit-regularitas dari suatu semigrup transformasi linear yang diperumum tersebut. Selanjutnya, juga dibahas mengenai karakterisasi dan beberapa sifat dari semigrup Smarandache dan hubungannya dengan semigrup transformasi linear yang diperumum. Hubungan tersebut meliputi syarat perlu dan syarat cukup agar suatu semigrup transformasi linear menjadi semigrup Smarandache.
MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS MATEMATIS PESERTA DIDIK DENGAN LEMBAR KERJA PESERTA DIDIK BERBASIS TEORI VAN HIELE
Authors: Wiska Siltima , Musdi Edwin , Permana Dony , Yerizon Yerizon
Published: February 2023

Kemampuan berpikir kritis merupakan kemampuan yang diperlukan dalam perkembangan dunia saat ini. Namun, kemampuan berpikir kritis peserta didik masih rendah. Halminimdisebabkan peserta didik masih ketergantungan kepada guru dalam menerima informasi serta pembelajaran yang terjadi di kelas belum memfasilitasi kemampuan berpikir kritisnya dalam bidang geometri. Untuk itu dikembangkan lembar kerja peserta didik berbasis teori Van Hiele yang diharapkan dapat membantu mengatasi masalah tersebut. Tujuan dari pengembangan produk ini yaitu untuk mmenghasilkan mlembar kerja peserta didik berbasis teori Van Hiele yang efektif dalam meningkatkan kemampuan berpikir kritis matematis peserta didik kelas VIII SMPN 13 Padang. Subjek penelitian ini adalah peserta didik kelas VIII SMPN 13 Padang. Model pengembangan yang digunakan diadaptasi dari model Plomp. Ada tiga tahapan pada model ini yaitu preliminary research, prototype phase, and assesment. Pada penelitian ini difokuskan melihat keefektifan produk pada tahap assesment. Tahap assesment dilakukan pada uji lapangan (field test) yang terdiri dari 30 peserta didik selama 6 kali pertemuan. Keefektivan produk dilihat setiap pertemuan pada tahap field test serta tes yang diberikan pada akhir pertemuan. Hasil penelitian diperoleh bahwa kemampuan berpikir kritis matematis peserta didik cenderung meningkat selama enam kali pertemuan serta tes akhir juga menunjukkan bahwa terjadinya peningkatan sebesar 73,33%.
PENGEMBANGAN MEDIA PEMBELAJARAN APLIKASI POKAMATHH PADA MATERI ALJABAR KELAS VII
Authors: Astuti Vina Dwi , Muthmainnah Rahmita Nurul , Rosiyanti Hastri
Published: February 2023

Tujuan dari pengembangan media POKAMATH ini adalah untuk menguji kevalidan dan kepraktisan media pembelajaran dengan menggunakan metode ADDIE yaitu: (1) Analisis, (2) Design, (3) Development, (4) Implementation, (5) Evaluasi. Penelitian ini dilatarbelakangi oleh kurang fokusnya siswa di dalam kelas pada saat guru menjelaskan di depan kelas. Kevalidan media di uji oleh 3 validator yaitu, ahli media, ahli materi dan ahli bahasa serta untuk kepraktisan media di berikan angket respon siswa dengan subjek penelitian adalah siswa SMPN 13 Tangerang Selatan dengan menggunakan teknik simple random sampling. Hasil dari skor akhir penilaian kevalidan dimulai dari materi, media dan bahasa mendapat skor akhir 100% dengan kategori sangat valid dan untuk siswa pada uji coba kelas kecil mendapat skor akhir kepraktisan 89% dengan kategori sangat praktis. Oleh sebab itu media POKAMATH yang dikembangkan valid dan praktis untuk digunakan oleh siswa
PENGARUH BAHAN AJAR BERBASIS PENALARAN MATEMATIS UNTUK MENINGKATKAN KEMAMPUAN KOMUNIKASI MATEMATIS
Authors: Angraini Lilis Marina , Sthephani Aulia , Ain Siti  Quratul
Published: February 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan mahasiswa, dalam hal ini kemampuan komunikasi matematis, melalui bahan ajar berbasis penalaran matematis. Penelitian ini adalah penelitian kuasi eksperimen dengan desain yang digunakan adalah pretes-postes. Pelaksanaan penelitian ini di Prodi PGSD terhadap mahasiswa semester I, yang mengikuti mata kuliah Konsep Dasar Matematika di SD pada tahun ajaran 2020/2021. Kelas eksperimen terdiri dari 30 mahasiswa dan kelas kontrol terdiri dari 30 mahasiswa. Pengumpulan data untuk penelitian ini dilakukan melalui tes, tes disusun dengan mengacu kepada indikator kemampuan komunikasi matematis. Analisis dalam penelitian ini dilakukan dengan uji normalitas, uji homogenitas dan uji ANOVA 2 jalur. Penelitian ini memperoleh kesimpulan bahwa (a) Tidak ditemukan perbedaan dalam hal pencapaian kemampuan komunikasi matematis mahasiswa, yang diajar melalui bahan ajar berbasis penalaran matematis dengan mahasiswa yang diajar melalui pembelajaran konvensional, dilihat secara keseluruhan; (b) Ditemukan perbedaan dalam hal pencapaian kemampuan komunikasi matematis mahasiswa, yang diajar melalui bahan ajar berbasis penalaran matematis dengan mahasiswa yang diajar melalui pembelajaran konvensional, dilihat berdasarkan KAM; (c) Tidak ditemukan interaksi antara pembelajaran yang digunakan dalam pembelajaran, dan kemampuan awal matematis (KAM) dalam hal pencapaian kemampuan komunikasi matematis mahasiswa.
EFEKTIVITAS PENGGUNAAN APLIKASI PEAR DECK DALAM PEMBELAJARAN DARING MATA KULIAH ALJABAR ABSTRAK LANJUT
Authors: Sa'adah Nihayatus , Rodliyah Iesyah
Published: February 2023

Pandemi Covid-19 mengubah pelaksanaan pendidikan di Indonesia. Kegiatan pembelajaran yang semula dilakukan secara tatap muka kini berubah menjadi pembelajaran daring. Pelaku pendidikan, tidak terkecuali di tingkat perguruan tinggi, harus beradaptasi dengan memanfaatkan teknologi yang ada agar kegiatan pembelajaran bisa terus berjalan efektif. Salah satu aplikasi yang dapat digunakan untuk melaksanakan pembelajaran daring yang memungkinkan interaksi dua arah antara dosen dan mahasiswa adalah Pear Deck. Penelitian eksperimen ini bertujuan untuk mendeskripsikan efektivitas penggunaan Pear Deck dalam pembelajaran daring dalam mata kuliah Aljabar Abstrak Lanjut ditinjau dari hasil belajar dan respon mahasiswa. Pengumpulan data dilakukan dengan memberikan tes dan angket respon yang diadaptasi dari the Triple E Framework pada 19 mahasiswa semester lima Universitas Hasyim Asy’ari yang memprogram mata kuliah Aljabar Abstrak Lanjut. Data yang didapat meliputi data hasil belajar mahasiswa yang dianalisis secara deskriptif untuk mendapatkan tingkat pencapaian serta data hasil angket yang dianalisis berdasarkan teori the Triple E Framework oleh Kolb. Hasil penelitian menunjukkan bahwa sebanyak 84% mahasiswa mendapat nilai di atas 80 dan tiga komponen dari teori the Triple E Framework (Engagement, Enhancement, dan Extension) terpenuhi. Dengan kata lain, penggunaan aplikasi Pear Deck efektif ditinjau hasil belajar dan respon mahasiswa dalam mata kuliah Aljabar Abstrak Lanjut
PENGGUNAAN INVERS MATRIKS DALAM MODIFIKASI FEISTEL CIPHER
Authors: Sylviani Sisilia , Permana Fahmi Candra , Singgih Asep , Ari Wiguna Nurendra
Published: February 2023

Umumnya, pada algoritma kriptografi modern sistem yang digunakan adalah sistem bit. Namun, hal tersebut membuat cipherteks semakin sulit untuk dipecahkan. Saat ini, Feistel cipher merupakan salah satu algoritma kriptografi modern yang banyak digunakan karena proses pengimplementasiannya yang cukup sederhana. Kelebihan lainnya adalah bahwa algoritma tersebut merupakan salah satu bentuk dari cipherblok yang dibentuk dengan menggunakan struktur yang simetris serta hingga saat ini masih sulit untuk dipecahkan. Adanya modifikasi pada feistel cipher ini bertujuan untuk meningkatkan keamanan dalam proses penyampaian pesan. Dengan modifikasi feistel cipher, pesan yang dikirimkan ke penerima akan sangat sulit dipecahkan karena membutuhkan waktu yang lama dalam memecahkannya.