bluuebunny/crossref_metadata_2025 huggingface dataset:
توظيف النوستالجيا كمصدر لإثراء الرؤية الإبداعية في الفن السعودي المعاصر
Authors: Al-Nahari Nourah Nasser
Published: February 2025

الأهداف: هدف البحث التعرف إلى دور توظيف النوستالجيا مصدرًا لإثراء الرؤية الإبداعية في الأعمال الفنية السعودية المعاصرة.
المنهجية: استُخدِم المنهج الوصفي التحليلي بأسلوبيه (النوعي والكمي)، وتكون مجتمع الدراسة من الفنانين والفنانات الذين يستخدمون مفهوم النوستالجيا، ومن بعض أعمالهم الفنية التي عُرضت في المملكة العربية السعودية. وقد استُخدِمت عينة قصدية ممثلة لمجتمع البحث (المقابلة) بلغ عددها (20) فردًا من الفنانين وأعضاء هيئة التدريس. واختير بعض الأعمال الفنية السعودية التي وُظف فيها النوستولجيا. باستخدام أداة تحليل المحتوى لتحليل الأعمال الفنية المختارة.
النتائج: اتفاق غالبية أفراد مجتمع الدراسة على أن مفهوم النوستالجيا في الفن السعودي المعاصر يتضمن الأعمال الفنية التي تحمل معاني الحنين للماضي والذكريات ، أن أبرز المداخل الفنية للتعبير عن النوستالجيا لدى الفن السعودي المعاصر تتجلى في الأعمال الفنية التشكيلية يليها فن التركيب، ثم النحت، ثم التصوير الضوئي ، تنامي الحركة الفنية السعودية في مختلف مجالات الفنون البصرية خلال المدة الزمنية من عام 2000 إلى عام 2023، وتبين أن توظيف النوستالجيا في الأعمال الفنية يساعد على تحفيز الأفكار الابتكارية لدى الفنان والمتلقي.
الخلاصة: لقد اتضح اتفاق غالبية أفراد مجتمع الدراسة على أن مفهوم النوستالجيا في الفن السعودي المعاصر يتضمن الأعمال الفنية التي تحمل معاني الحنين للماضي والذكريات، سواء أكانت أشياء، أو ذكريات، أو أماكن، وتبين من آراء الفنانين المشاركين أن توظيف النوستالجيا يساعد على تحفيز الأفكار الابتكارية لدى الفنان والتي تُستَقى من ذكريات الحنين، ومن ثَم فإن توظيف النوستالجيا يعمل على إثراء الرؤية الإبداعية لدى الفنان والمتلقي.
التحولات الأخلاقية والمهنية في توظيف تقنيات الذكاء الاصطناعي في صناعة محتوى الإعلام الرقمي
Authors: Abu Draz Ahed Maher
Published: February 2025

الأهداف: هدفت الدراسة التعرف إلى التحولات الأخلاقية والمهنية في توظيف تقنيات الذكاء الاصطناعي في صناعة محتوى الإعلام الرقمي، كما هدفت الدراسة إلى تقييم مستوى وعي الإعلاميين والأكاديميين في مجال الإعلام بمدى تأثير تقنيات الذكاء الاصطناعي على الأبعاد الأخلاقية والمهنية لصناعة محتوى الإعلام الرقمي.
المنهجية: تتبع الدراسة منهج المسح، وتكون مجتمع الدراسة من جميع الإعلاميين والأكاديميين في مجال الإعلام في دولة الإمارات العربية المتحدة. وتم توزيع الاستبانة بشكل إلكتروني، وتم استرداد عدد (160) استبانة، مثلت عينة الدراسة الحقيقية. وتم استخدام الاستبانة كأداة لجمع البيانات.
النتائج: بينت الدراسة أن من أهم التحولات الأخلاقية والمهنية التي تفرضها تقنيات الذكاء الاصطناعي في مؤسسات الإعلام الرقمي هي استبدال بعض الوظائف بتقنيات الذكاء الاصطناعي، وتغيير طريقة الوصول للمصادر، وتغيير طرائق وأساليب البحث والتقصي عن المعلومات، وتغيير أساليب بناء المحتوى.
إن مستوى تقييم الأبعاد الأخلاقية التي تفرضها تقنيات الذكاء الاصطناعي في مؤسسات الإعلام الرقمي جاء بوزن نسبي (67.797)، وهو بدرجة موافقة (متوسطة).
إن مستوى تقييم الأبعاد المهنية التي تفرضها تقنيات الذكاء الاصطناعي في مؤسسات الإعلام الرقمي جاء بوزن نسبي (68.438)، وهو بدرجة موافقة (كبيرة).
الخلاصة: كشفت الدراسة ضرورة الاستفادة من تقنيات الذكاء الاصطناعي في صناعة محتوى الإعلام الرقمي، والحدّ من التأثيرات السلبية لتقنيات الذكاء الاصطناعي في مجال الإعلام الرقمي، وصياغة دليل أخلاقي ومهني يضبط توظيف تقنيات الذكاء الاصطناعي.
Les « petits jeux » : vers la définition d’un genre hobbyiste, indépendant, amateur et son application à l’histoire des jeux vidéo pornographiques
Authors: Courtois Charlotte
Published: February 2025

La classification des jeux dans des catégories de genre absolu (aventure, action, etc.) est un phénomène toujours voué à l’échec, tant les appellations varient dans le temps et selon les interlocuteur·rice·s. Les genres sont destinés à rester contextuels, et leur pertinence à être questionnée. Dans le cas de l’étude de l’histoire des jeux pornographiques sur micro-ordinateur des années 1980 (Commodore 64 et ZX Spectrum), il est utile de réunir sous l’appellation de « petits jeux », tous les titres de (très) courte durée et dont la jouabilité et le thème évoquent soit plusieurs genres, soit aucun genre de jeu préétabli. Les petits jeux sont un commentaire sur les modes de création de jeux vidéo et permettent d’exprimer des messages qui seraient perdus dans des jeux de toute autre échelle. Cette forme persistante à travers l’histoire permet de mettre en avant des expériences de jeu moins chronophages, moins techniques et moins énergivores que les jeux grand public, et des jeux créés souvent par une seule personne, plutôt que par l’équipe d’un studio de développement.
Antimicrobial effect of resveratrol on an etiological agent of human dental caries, Streptococcus mutans
Authors: Santos Débora Rafaella Mendes dos , Coelho Eduardo Sérgio Souza , Martins Valdo Soares , Souza Ludmilla Regina , Cardoso Filho Otávio
Published: February 2025

Aim: To evaluate the antimicrobial effect of resveratrol on the bacterium S. mutans.
Methods: In the execution of the study, samples were cultured on petri dishes plated with Mueller-Hinton Agar, containing sterile 6 mm diameter Blank discs (Cecton). The discs were soaked with 10 μl of negative control (phosphate-buffered saline - PBS), positive control (0.12% chlorhexidine), and different concentrations of resveratrol (100 μg/mL, 200 μg/mL, 400 μg/mL, and 800 μg/mL). The tests were performed in triplicate, totaling 18 analyses.
Results: After 24 hours of incubation, the halos were evaluated and measured using a digital caliper. The data collected were processed statistically using the Anova way program. The diameter measurement for the positive control halo was 2.84 cm; for the resveratrol at 800 μg/mL, it was 0.6 cm; at 400 μg/mL, it was 0.42 cm; and at 200 and 100 μg/mL, it was zero.
Conclusion: Resveratrol did not demonstrate efficiency against the bacteria when compared to the negative control (PBS). According to literature, resveratrol produces an antibacterial activity, although its optimal concentration for inhibitory effect is not yet well established.
An End-to-End Pipeline for Medical Image Enhancement Using GANs Architecture
Authors:   Department of Computer Science Engineering, University of Toronto., Singh Jaskaran , Patel Tirth ,   Department of Computer Science Engineering, University of Toronto., Dankar Apoorv ,   Department of Computer Science Engineering, University of Toronto.
Published: February 2025

Medical Imaging is used by radiologists for diagnostic purposes and to check for abnormalities, and these imaging techniques involve radiation. Overexposure to radiation can harm the human body, and using less radiation gives us a noisy output. Hence, radiologists find it difficult as there is a trade-off between the amount of radiation that can be used and the quality of the image. Moreover, noise in medical images can occur due to fluctuation of photons, a reflection of radiations from the subject, or due to instrumental vibration or faults. The proposed approach is a pipeline that starts with denoising using GANs architecture, in which two models have been trained, one for handling all kinds of noise and the second one specifically for Poisson noise. Further, post-processing methods like single-shot HDR using Retinex Filtering and Edge Enhancement using unsharp masking have been done to get a structurally more similar and enhanced denoised image.
An Integrated Framework for Risk Management in Procurement: Construction Projects in India
Authors:   Department of Masters of Building and Engineering Management, School of Planning and Architecture, Vijayawada (Andhra Pradesh), India., Deepika MB  , Myneni Dr. Kranti Kumar ,   Department of Masters of Building and Engineering Management, School of Planning and Architecture, Vijayawada (Andhra Pradesh), India.
Published: February 2025

High susceptibility to risk characterises the construction sector, as it operates within intricate and everchanging project settings that generate an ambience of substantial unpredictability and risk. The report aims to create an integrated framework for effectively managing procurement-related risks in the Indian construction industry by identifying and analysing the risks associated with the procurement process in a project, analysing the severity and probability of the identified risks, and identifying risk mitigation techniques concerning procurement in construction. The paper discusses the nature and complexity of construction projects, the different types of risks that can occur during various project stages, and the importance of risk analysis and management during project planning. Data collection involves a literature review through which risk management and procurement risks are identified, followed by the further collection of primary data through two surveys with professionals. The analysis of data through Principal component factor analysis for prioritisation of risks is followed by the framework. The research uncovers that in construction projects in India, the dominant risks occur during planning, including procurement delays and inefficiencies in the organisational structure, which overshadow legal considerations. The study highlights the importance of earlystage risk management to minimise later-stage consequences. The framework supports preventive measures and offers a strong strategy for risk reduction. The thesis recommends further research to explore real-world applications, considering contextual factors.
PERENDAMAN JUS KEMASAN TERHADAP KEKASARAN DAN KEKERASAN RESIN KOMPOSIT NANOHIBRID
Authors: Anjani Salsabila
Published: February 2025

Latar belakang: Resin komposit nanohybrid merupakan kombinasi antara nanopartikel dan microhybrid, yang memiliki banyak kelebihan. Resin komposit nanohybrid memiliki kekurangan yaitu absorpsi cairan. Bahan makanan atau minuman yang mengandung asam dapat berpengaruh pada kekasaran dan kekerasan resin komposit nanohybrid. Jus jambu biji kemasan mengandung asam dan mempunyai nilai pH yang rendah. Tujuan: Untuk mengetahui pengaruh perendaman jus jambu biji merah kemasan terhadap kekasaran dan kekerasan resin komposit nanohybrid. Metode: Penelitian ini merupakan eksperimental laboratoris dengan rancangan post test with control group design dengan jumlah sampel sebanyak 24 sampel resin komposit nanohybrid yang dibentuk menggunakan stainless steel mold berdiameter 10 mm dan ketebalan 2 mm (sampel dibagi menjadi 2 kelompok; kelompok perlakuan dan kelompok kontrol). Kelompok kontrol direndam selama 24 jam dalam saliva buatan, sedangkan kelompok perlakuan direndam selama 6 jam dalam jus jambu biji merah kemasan dilanjutkan dengan perendaman dalam saliva buatan selama 18 jam. Perendaman sampel dilakukan selama 4 hari dalam inkubator dengan suhu 37°C. Uji kekasaran permukaan menggunakan surface roughness tester dan uji kekerasan menggunakan micro vickers hardness. Hasil: Berdasarkan uji analisa one way ANOVA, kekasaran permukaan (p: 0,001) dan kekerasan (p: 0,003) menunjukkan perbedaan perubahan bermakna (p<0,05). Kesimpulan: Perendaman menggunakan jus jambu biji merah kemasan setelah direndam 6 jam selama 4 hari terjadi peningkatankekasaran dan penurunan kekerasan.
HUBUNGAN PERILAKU IBU HAMIL DENGAN STATUS KEBERSIHAN GIGI DAN MULUT DI PUSKESMAS SIBREH ACEH BESAR
Authors: Kurniawati Nia Niakurniawati
Published: February 2025

Perilaku ibu hamil sangat perlu diperhatikan karena pada saat kehamilan ibu hamil sangat rentan terkena penyakit gigi dan mulut seperti karies gigi dan kalkulus. Biasanya ibu hamil pada saat kehamilan malas dalam menjaga kebersihan gigi dan mulut disebabkan rasa mual dan muntah sehingga menyikat gigi kadang-kadang dilakukan saja. Tujuan penelitian untuk mengetahui hubungan perilaku ibu hamil dengan status kebersihan gigi dan mulut di Puskesmas Sibreh Aceh Besar. Jenis penelitian analitik dengan desain cross sectional. Populasi dalam penelitian adalah seluruh ibu hamil yang berkunjung untuk memeriksakan kehamilan di Poli KIA Puskesmas Sibreh Aceh Besar selama seminggu dan memenuhi kriteria jumlah sampel. Sampel penelitian menggunakan accidental sampling yang berjumlah 30 responden. Pengumpulan data melalui wawancara menggunakan kuesioner dan pemeriksaan kebersihan gigi dan mulut. Analisa data menggunakan uji statistic chi–squre. Hasil penelitian menunjukkan pengetahuan terbanyak pada kategori kurang baik 66,7%, sikap pada kategori kurang baik 56,7%, tindakan pada kategori kurang baik 63,3% dan status kebersihan gigi dan mulut pada kategori buruk 43,3%. Dapat disimpulkan bahwa ada hubungan pengetahuan ibu hamil dengan status kebersihan gigi dan mulut (P value = 0,036), ada hubungan sikap dengan status kebersihan gigi dan mulut (P value = 0,026), ada hubungan tindakan dengan status kebersihan gigi dan mulut (P value = 0,008). Disarankan kepada ibu hamil untuk meningkatkan pengetahuan tentang kebersihan gigi dan mulut dengan mengikuti kegiatan penyuluhan yang diadakan oleh tenaga kesehatan dan rajin menyikat gigi minimal dua kali sehari.
Early Childhood Caries : Tinjauan Pustaka
Authors: Natasha Vanny Putri
Published: February 2025

ABSTRAK
 
Early Childhood Caries (ECC) merupakan suatu penyakit multifaktorial yang menyebabkan masalah kesehatan rongga mulut pada anak. ECC paling sering terjadi pada anak-anak usia dibawah 6 tahun. Prevalensi ECC di Indonesia meningkat dari tahun ketahun. Morfologi gigi sulung, makanan kariogenik dan bakteri Streptococcus mutans menjadi faktor etiologi terjadinya karies. Penggunaan botol susu yang lama saat tidur dimalam hari juga menjadi faktor risiko terjadinya ECC. ECC dapat menyebabkan berbagai keluhan seperti kesulitan makan, mengunyah dan berbicara, selanjutnya akan mempengaruhi tumbuh kembang anak sehingga perlu dilakukan pencegahan dan perawatan ECC pada anak sedini mungkin.
 
Kata kunci : ECC, anak-anak, pencegahan
 
ABSTRACT
Early Childhood Caries (ECC) is a multifactorial disease that causes oral health problems in children. ECC most often occurs in children under 6 years of age. The prevalence of ECC in Indonesia increases from year to year. The morphology of primary teeth, cariogenic foods and Streptococcus mutans bacteria are etiological factors in the occurrence of caries. Prolonged use of milk bottles while sleeping at night is also a risk factor for ECC. ECC can cause various complaints such as difficulty eating, chewing and speaking, which will then affect the child's growth and development, so it is necessary to prevent and treat ECC in children as early as possible.
 
Key words: ECC, children, prevention
PEMELIHARAAN KEBERSIHAN GIGI DAN MULUT SISWA KELAS 5 SETELAH MENGGUNAKAN MEDIA PAPAN GAME
Authors: Ghufron Moh. Rojil , Mahirawatie Ida Chairanna , Astuti N.P I.G.A. Kusuma
Published: February 2025

Latar Belakang: Pemeliharaan kebersihan gigi dan mulut anak Sekolah Dasar sangat penting pada pencegahan pertumbuhan debris indeks. Debris indeks yang buruk terjadi dikarenakan anak kurang memelihara kebersihan gigi dan mulut, debris akan mengumpul bersama dengan saliva membentuk plak yang mengandung bakteri. Tujuan Penelitian ini adalah Mengetahui gambaran tingkat pengetahuan mengenai pemeliharaan kebersihan gigi dan mulut siswa kelas 5 terkait tingginya debris indeks setelah menggunakan media papan game.
Metode: Penelitian ini bersifat deskriptif yang dilaksanakan di SDN Pesanggrahan 1 Bangkalan. Sampel yang digunakan adalah teknik total sampling yaitu seluruh siswa kelas 5 yang berjumlah 40 orang.
Hasil: Hasil penelitian menunjukkan pengetahuan pemeliharaan kebersihan gigi dan mulut  siswa kelas 5 setelah meggunakan media papan game dalam kategori baik (90%) tentang waktu menyikat gigi yang benar, (88%) tentang cara memilih dan merawat sikat gigi, (93%) tentang pola makan yang baik, (87%) tentang periksa gigi secara rutin, (80%) tentang cara menyikat gigi yang benar.
Kesimpulan: Kesimpulan dari penelitian ini bahwa penyuluhan dengan menggunakan media papan game efektif untuk meningkatkan pengetahuan siswa tentang pemeliharaan kebersihan gigi dan mulut dengan rata-rata (87,6%) termasuk dalam kategori baik.
PERBEDAAN KARAKTERISTIK FILM KITOSAN (SCYLLA SERRATA) DENGAN PENGENTAL GELATIN DAN XANTHAN GUM SEBAGAI MEDIA PENGHANTARAN OBAT DALAM TERAPI PERIODONTAL
Authors: Negara Mellani Cindera
Published: February 2025

Latar belakang: Produksi limbah cangkang kepiting bakau yang mencapai 75% dari total produksi memiliki kandungan kitin. Kandungan kitin yang ada di dalam cangkang kepiting dapat dimanfaatkan sebagai bahan baku kitosan. Kitosan yang dikombinasikan dengan pengental gelatin dan xanthan gum dapat digunakan sebagai bahan baku pembuatan film periodontal. Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan karakteristik film kitosan (Scylla serrata) dengan pengental gelatin dan xanthan gum sebagai media penghantaran obat dalam terapi periodontal. Metode: penelitian ini merupakan penelitian deskriptif kuantitatif dengan subjek berupa film dari kitosan (Scylla serrata) dengan pengental gelatin dan xanthan gum. Sampel terdiri dari 1 jenis film kitosan-gelatin dan 1 jenis film kitosan-xanthan gum yang dipotong dengan ukuran sesuai standar alat uji karakteristik film. Hasil: karakteristik film kitosan-xanthan gum lebih baik dan memenuhi standar dalam penilaian karakteristik film periodontal, sehingga disimpulkan bahwa film dari kitosan (Scylla serrata) dengan pengental xanthan gum memiliki nilai karakteristik film yang lebih baik dan memenuhi syarat dibandingkan dengan penggunaan kombinasi bahan kitosan dengan pengental gelatin sebagai sediaan dalam sistem penghantaran obat khususnya untuk terapi periodontal.
Kata Kunci: Film, kitosan (Scylla serrata), terapi periodontal, gelatin, xanthan gum
Efektifitas Penggunaan Dental Story E-Book terhadap Peningkatan Pengetahuan tentang Karies pada Anak Sekolah Dasar
Authors: Widodo Yufen , Ismalayani Ismalayani , Hanum Nur Adiba
Published: February 2025

Background: Dental caries is a disease that destroys tooth tissues, starting from the enamel, then the dentin, until it reaches the pulp. Increased knowledge can shape better and healthier behaviors. One way to increase knowledge is through education, especially using digital technology that is popular among children. Dental story e-book is a digital storybook containing text, images, and colors, which can be read through electronic devices. The purpose of this study was to determine the effectiveness of using Dental Story E-Books in increasing knowledge about dental caries in elementary school children. Methods: A quasi-experimental design with a pretest-posttest and control group was used. The questionnaire used has been tested for validity and reliability. The research sample consisted of 40 fifth-grade students at SDN 115 Palembang, selected through purposive sampling. A paired t-test was used. Results: The paired t-test resulted in a p-value of 0.001 (p<0.05), indicating that the use of Dental Story e-books was significantly effective in increasing knowledge about dental caries in elementary school children. Conclusion: The use of Dental Story E-Books is effective in increasing knowledge about dental caries in elementary school children.
Albrecht von Haller’s Self-Reviews and Style of Reasoning
Authors: Gantet Claire
Published: February 2025

Despite the review ethos introduced by the physician Albrecht von Haller when he took over the Göttingische gelehrte Nachrichten as chief editor in 1747, he wrote many self-reviews. This article examines von Haller’s numerous self-reviews in order to explore the aims of reviewing, the openness of scholarship, the relationship between reviewing and truth, and the scientific language used, which can be summarised as what Marco Sgarbi, in a stimulating article, has called a “style of reasoning.” Reviews and self-reviews did not develop as an autonomous genre, but were integrated into a system of intermediality in which publications, reviews, (semi-)private letters and images responded to one another. They were primarily aimed at correcting and advancing science in the complexity of his intellectual, personal and cultural options.
“Contributions to a Kantology”. Schleiermacher’s Critical Assessment of Anthropology from a Pragmatic Point of View
Authors: Martinelli Riccardo
Published: February 2025

The paper examines Friedrich Schleiermacher’s 1799 review of Immanuel Kant’s Anthropology from a Pragmatic Point of View. Schleiermacher’s critique, published anonymously in the Athenaeum, adopts a harsh and ironic tone, deeming Kant’s work as trivial and flawed. Schleiermacher argues that Kant’s attempt to reconcile systematic and popular elements within his anthropology led to its failure, coining the term “Kantology” to refer to a superficial study of Kant’s personality rather than a substantive contribution to anthropology. Schleiermacher contends that Kant’s anthropology is internally inconsistent and overly reliant on a rigid distinction between physiological and pragmatic anthropology. According to Schleiermacher, this distinction oversimplifies human nature by neglecting the necessary unity between bodily and mental aspects. The paper highlights how Schleiermacher’s review is an important critique of Kant’s Anthropology, providing insights into both Kant’s and Schleiermacher’s philosophical views. Schleiermacher criticizes Kant’s approach as falling into “lower realism,” missing the transcendental and “higher realism” that he associates with religion and human freedom. Despite its acerbic tone, the review is seen as a valuable contribution to the study of Kant’s anthropology and Schleiermacher’s philosophical development. Schleiermacher’s review raises fundamental questions about the compatibility of Kant’s anthropology with his broader critical philosophy and offers a re-evaluation of how Kant’s ideas on human nature, freedom, and history are integrated into his system of thought.
Managing Music Teaching Activities at Primary Schools in Binh Thanh District, Ho Chi Minh City According to the 2018 General Education Program
Authors: Hai Hoang
Published: February 2025

The purpose of this study is to explore and identify the contents of music teaching management in primary schools in Binh Thanh district, Ho Chi Minh City according to the 2018 General Education Program. This study uses qualitative and quantitative research methods to achieve this purpose. Based on the analysis of theoretical issues, this study conducted a survey of 90 people, including 30 managers, the remaining 60 were professional group leaders, some homeroom teachers who had concurrently taught music and specialized music teachers of 9 primary schools in Binh Thanh district. The survey results show that the management of music teaching activities in primary schools in Binh Thanh district, Ho Chi Minh City according to the 2018 General Education Program still has many shortcomings in terms of objectives, content, methods, testing and evaluation, and conditions for teaching activities. Based on the analysis and assessment of the current situation, this study proposes solutions to contribute to improving the quality of music teaching, innovating in the direction of promoting students’ positivity and bringing high efficiency in teaching towards promoting the capacity and qualities of primary school students.
The Attractiveness of External Marketing on Patients' Desire to Revisit Lavalette Hospital
Authors: Kodriyah Lailatul , Mustajabah Faisal
Published: February 2025

External marketing is a vital marketing communications strategy for establishing relationships with customers, providing information about the company's commitment, and explaining how the service will be provided. Lavalette Hospital, as a health service institution, recorded fluctuations in the number of outpatient visits between 2019 and 2024. This research aims to analyze the relationship between the application of external marketing and patient interest in repeat visits at the hospital. Using a cross-sectional approach, this research collects data observationally to identify correlations between existing variables. The results of the analysis show that there is a positive relationship with a correlation coefficient of 0.460, which indicates that the more effective the external marketing strategy, the higher the patient's interest in making repeat visits. With a p-value of 0.000 (p < 0.05), the alternative hypothesis is accepted, confirming that external marketing has a significant influence on the patient's decision to return to visit. This finding is in line with previous studies which show that the marketing mix has a significant impact on outpatient loyalty. These results emphasize the importance of implementing appropriate marketing strategies to increase patient satisfaction and interest in repeat visits at Lavalette Hospital.
Exchange Rate and Performance of Manufacturing Industry in Nigeria
Authors: Gbarawae NWIKINA Christian , Wadi Elizabeth Oghenetega , Wilson Kenigheni Good , Edi Matthew Favour
Published: February 2025

This study examines the effect of exchange rate on the performance of manufacturing industry between 1985 and 2022. The study proxied of exchange rate by real exchange rate, external reserve and trade openness while the performance of manufacturing industry was measured by manufacturing sector GDP. The theories adopted comprise: Purchasing Power Parity (PPP), Theory, Optimal Currency Area (OCA) Theory and Theory of Production. Annual temporal data for the study were sourced from Central Bank of Nigeria (CBN) statistical bulletin and Word Development Indicators (WDI) of the Word Bank. The techniques of data analysis adopted are unit root test, co-integration test and error correction model (ECM) approach. The study found that real exchange rate has a substantial unfavourable effect on manufacturing sector GDP in Nigeria, external reserve has a favourable and substantial effect on manufacturing sector GDP in Nigeria while trade openness has a favourable and substantial effect on manufacturing sector GDP in Nigeria. As per the finding, the study concluded that exchange rate plays a substantial role influencing the performance of manufacturing industry in Nigeria. The study recommended that government should formulate efficient and feasible trade policies that will liberalize trade and open the Nigerian manufacturing sector to foreign investors.
Epidemiological, Clinical, and Radiological Profile of Cerebrovascular Accidents in Intensive Care at the Essos Hospital Centre: A Retrospective Study of a Cameroonian Cohort
Authors: Raissa Iroume Bifouna Cristella , Vivier Nga Nomo Serge , Aristide Kuitchet , Toussaint Binam Bikoi Charles Emmanuel , Bonaventure Jemea
Published: February 2025

Objectives: This retrospective study seeks to delineate the epidemiological, clinical, and radiological profiles of patients admitted to the intensive care unit (ICU) for stroke at the Essos Hospital Center, a tertiary care facility in Cameroon. Methods: We conducted a comprehensive analysis of the clinical records of all patients diagnosed with stroke and admitted to the ICU between January 2019 and December 2024. Data on demographics (age, sex, risk factors), clinical characteristics (stroke subtype, Glasgow Coma Scale score at admission, clinical manifestations), and radiological findings (stroke type based on neuroimaging, lesion localisation) were systematically collected and subjected to descriptive statistical analysis. Results: Of the 100 patients included, the mean age was 63 years, with a predominance of male patients (70%). Ischaemic strokes represented 65% of cases, while haemorrhagic strokes accounted for 35%. Hypertension (75%), diabetes mellitus (30%), and smoking (25%) were the predominant risk factors. Neuroimaging, particularly computed tomography (CT), identified cerebral infarctions in 60% of cases and intracerebral haemorrhages in 30%. The overall ICU mortality rate was 40%, with key prognostic factors including advanced age, low Glasgow Coma Scale score at admission, and the specific localisation of cerebral lesions. Conclusions: This study underscores the high prevalence of ischaemic strokes and the significant role of modifiable risk factors in the aetiology of stroke. Strokes remain a leading cause of mortality in the ICU in Cameroon. Early intervention and optimised management of modifiable risk factors hold potential for improving clinical outcomes in this patient population.
Deciphering of Nature’s Promising Warrior of Some Novel Flavonoid Derivatives against Psoriasis: In-silico Molecular Docking against Phosphodiesterase 4 Enzyme
Authors: Singh Savita , Malik Jitender , Singh Surendra Pratap
Published: February 2025

Background: An inflammatory, prevalent, and chronic skin disease is psoriasis. The term "classic skin lesions" refers to the erythematous, scaly, and well-defined plaques that are frequently located on the extensor surfaces. There have also been several psoriasis variations reported, such as the guttate, erythrodermic, pustular, and palmoplantar types. Psoriasis is typically diagnosed clinically, although distinctive histologic findings include a lymphocytic infiltration, dilated blood vessels, and hyper- and parakeratosis of the epidermis. Although the exact cause of psoriasis is unknown, genetic and environmental factors have been linked to the immune-mediated disease. Many health advantages are associated with flavonoids, such as their antiviral, anticancer, and antioxidant qualities. They also have cardio- and neuroprotective properties. The kind of flavonoid, its (potential) method of action, and its bioavailability all affect these biological functions. These reasonably priced pharmaceutical ingredients contain substantial biological activities and have been shown to be beneficial for a range of illnesses. Purpose: The present study was conducted to evaluate the efficacy of new flavonoid derivatives for their anti-psoriatic potential. Methodology: The scientific validation of the present work was conducted using a computational molecular docking analysis of the lead compounds luteolin, baicalein, and myricetin against the PDE4 enzyme. Result: The results of the current analysis indicate that the selected lead compounds are efficient anti-psoriatic agents, demonstrating binding affinities to the target protein PDE4 with binding energies of -7.269, -7.16, and -6.64 kcal/mol for baicalein, luteolin, and myricetin, respectively. Conclusion: The results demonstrated that each chosen lead compound for further study exhibited substantial inhibitory efficacy against PDE4, hence indicating its potential as an anti-psoriatic drug.
Systematic Literature Review: Fenomena Viktimisasi pada Kencan Online dan Usaha Pencegahannya
Authors: Rahma Hanifa Miftahur , Ayunarendra Victoria Kesha
Published: February 2025

Aplikasi Kencan Online yang kian popuer dikalangan dewasa muda merupakan inovasi dalam perkembangan teknologi yang memabwa perubahan pada pola hubungan romantis penggunanya. Dibalik kemudahan komunikasi dan keefektifan dalam menjalin hubungan yang diatwarkan aplikasi ini, ada resiko besar yang dibawa olehnya. Viktimisasi menjadi fenomena yang lekat dengan pengguna aplikasi kencan online dan sering dikaitkan dengan istilah Cyber Dating Abuse, yang berfokus pada perilaku kekerasan dalam hubungan romantis yang dengan menggunakan teknologi. Viktimisasi sendiri terbagi atas beberapa variabel, mulai dari pelecehan emosional, sexting, kontrol kasar, hingga berlanjut pada Offline Dating Abuse. Fenomena global ini harus dipelajari dari pendekatan yang berbeda dan dimensi pendidikan adalah salah satu yang paling relevan. Penelitian ini bertujuan untuk menganalisis fenomena viktimisasi dalam konteks aplikasi kencan online dengan pendekatan pendidikan. Tinjauan sistematis literatur (2019-2023), mengikuti protokol PRISMA, dilakukan dengan menganalisis artikel (n=17) yang diambil dari database Scopus. Perangkat lunak manajemen referensi dan penambangan teks digunakan untuk menganalisis data. Delapan pertanyaan penelitian dijawab pada kerangka konseptual, karakteristik bibliometrics dan dimensi pedagogik. Dari hasil analisis isi muncul visi peran pendidikan di beberapa tingkat lingkungan (keluarga, sekolah, pemerintah, media) untuk turut serta mencegah terjadinya viktimisasi dari aplikasi kencan online. Perkembangan pemikiran kritis, berbagi pengalaman dalam konstruksi bersama pengetahuan, dan nilai-nilai self esteem sangat mendasar melawan viktimisasi.
Laporan Kasus Pasien Penderita Ulkus Kornea
Authors: Mutiara Firdani , Anggraini Irastri
Published: February 2025

Ulkus kornea merupakan kondisi oftalmologis serius yang ditandai dengan kerusakan epitel kornea dan inflamasi stroma akibat trauma atau infeksi, yang dapat menyebabkan komplikasi berat hingga kebutaan jika tidak ditangani dengan tepat. Kasus ini melaporkan seorang pria berusia 55 tahun yang datang ke Klinik Mata RSWN dengan keluhan mata kiri merah selama 10 hari, disertai nyeri, sensasi panas, pandangan buram, dan pelebaran lingkaran putih pada kornea setelah terkena daun pohon timun saat panen. Pasien sempat mencoba pengobatan alternatif, namun kondisi semakin memburuk. Penelitian ini bertujuan untuk mengevaluasi pendekatan diagnostik dan terapi dalam penanganan ulkus kornea akibat trauma. Metode yang digunakan dalam studi ini adalah analisis kasus berbasis pemeriksaan klinis menggunakan slit lamp, tes fluorescein, dan evaluasi ketajaman penglihatan. Hasil pemeriksaan menunjukkan kornea keruh, defek positif, hipopion positif, dan hasil tes fluorescein positif, dengan tajam penglihatan VOD 6/9 dan VOS 6/40. Diagnosis utama adalah ulkus kornea OS dengan diagnosis banding corpus alienum kornea dan keratitis non-ulcerative. Terapi yang diberikan meliputi antibiotik topikal dan oral, analgesik, serta suplemen untuk mendukung penyembuhan. Meskipun prognosis untuk kelangsungan hidup pasien baik, pemulihan fungsi penglihatan masih dipertimbangkan dengan tingkat keberhasilan yang tidak pasti. Kasus ini menekankan pentingnya diagnosis dini dan terapi berbasis bukti dalam pengelolaan ulkus kornea untuk mencegah komplikasi yang berpotensi mengancam penglihatan.
CHANGES IN THE ACID-BASE PROPERTIES OF LEACHED CHERNOZEM WHEN USING CHEMICAL AMELIORANTS AND POULTRY MANURE
Authors:   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", OCHKINA N.S. , AREFIEV A.N. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", KUZIN E.N. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University", KUZINA E.E. ,   Federal State Budgetary Educational Institution of Higher Education "Penza State Agrarian University"
Published: February 2025

The aim of the study was to investigate the effect of different rates of marl, dolomite flour and their combinations with poultry manure on the acid-base properties of leached chernozem. To solve these problems in the first agro-soil district of Penza region we conducted field studies in the period from 2020 to 2022. The results showed that the use of marl and dolomite flour had an equal effect on the acid-base properties of leached chernozem, and the highest effect in this case was provided by the ameliorant rate equal to 1.5 Ng. The application of marl and dolomite meal at the rate of 1.5 Ng together with poultry manure had the most significant effect on the increase of cation exchange capacity, the sum of exchangeable bases, pHsalt value and decrease of hydrogen ions concentration in soil absorbing complex. Amount of cation exchange capacity when marl and dolomite meal were added together with poultry manure increased by 2.6-2.7 mg-eq./100 g, the amount of exchangeable bases - by 4.8-4.9 mg-eq./100 g, pHsalt - by 1.37-1.38 units, concentration of hydrogen ions in soil absorbing complex decreased by 2.20 mg-eq./100 g.
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant
Authors: Lestari Sri Indah , Dalimunthe Gabena Indrayani , Lubis Minda Sari , Nasution Haris Munandar
Published: February 2025

Kembang kol (Brassica oleracea var. botrytis L.) memiliki kandungan zat gizi yang terdiri dari kalsium, magnesium, kalium, fosfor, lemak jenuh yang rendah. dan memiliki vitamin C yang membantu meningkatkan imunitas tubuh. Sediaan Orally Disintegrating Tablet dapat cepat larut jika diletakkan diatas lidah, diformulasikan untuk kemudahan penggunaan obat bagi pasien yang kesulitan menelan. Oleh karena itu, bahan penghancur sangat penting pada sediaan ODT. Sari tapai memiliki rasa manis, sedikit asam dan segera hancur bila diletakkan di lidah. Tujuan penelitian ini untuk mengetahui apakah serbuk kembang kol dengan penghancur sari tapai dapat diformulasikan menjadi sediaan ODT dan formulasi manakah yang terbaik. Penelitian ini meliputi karakterisasi simplisia, pembuatan preformulasi dengan pencampuran semua bahan, evaluasi preformulasi, pencetakan tablet dengan metode kempa langsung. Kemudian dilakukan evaluasi tablet. Bahan penghancur yang digunakan yaitu sari tapai dengan konsentrasi 5%,7,5% dan 10%. Data dianalisis dengan metode One Way ANOVA.  Hasil evaluasi preformulasi, uji waktu alir yang diperoleh <10 detik yaitu mudah mengalir, uji sudut diam diperoleh 26˚ kategori sangat baik, dan uji kompresibilitas diperoleh 18-20% kategori cukup baik. Hasil evaluasi tablet pada uji organoleptis diperoleh tablet berbentuk bulat, rasa manis, warna putih kecoklatan dan bau khas. Uji keseragaman bobot pada semua formula tidak ada bobot yang menyimpang, uji keseragaman ukuran telah memenuhi syarat, uji kekerasan yang diperoleh 1-3 kg, uji kerapuhan diperoleh 0,4-0,7%, uji waktu hancur cawan petri diperoleh 44,07-52,48 detik, uji waktu hancur mulut diperoleh 53,07-57,78 detik dan uji waktu pembasahan diperoleh 53,21-54,87 detik. Formula terbaik adalah formula dengan konsentrasi sari tapai 10%.
UM ESTUDO SOBRE O MELANOMA METASTÁTICO: AVANÇOS TERAPÊUTICOS E PERSPECTIVAS FUTURAS
Authors: Delgado Lucas Prestes , Da Silva Priscila Bruna , Rocha Bruno Martins , Martins Francisca de Assis Fernandes , Neto Antônio Heleno de Brito , De Araújo Pedro Henrique , Mendonça Sueverton Mariano , Regis Manuella do Nascimento , Junior Enok Macedo da Gama , Vilarinho Sandra Luiza Noleto
Published: February 2025

O melanoma metastático representa um dos tipos mais agressivos de câncer de pele, caracterizado por alta taxa de mortalidade e resistência terapêutica. Nos últimos anos, avanços significativos nas terapias-alvo e imunoterapias revolucionaram o manejo da doença, proporcionando melhores taxas de resposta e sobrevida global. Esta revisão sistemática teve como objetivo analisar os avanços terapêuticos e as perspectivas futuras para o tratamento do melanoma metastático, com foco em estratégias inovadoras como inibidores de checkpoint imunológico, terapias combinadas e biomarcadores preditivos. A metodologia adotada envolveu uma busca criteriosa em bases de dados científicas, com a seleção de 6 artigos a partir de um total de 180 estudos inicialmente identificados. Os resultados evidenciaram que terapias como a combinação de inibidores de PD-1 e LAG-3, bem como o uso de inibidores de BRAF e MEK em pacientes com mutação BRAF V600, demonstraram impacto positivo na sobrevida livre de progressão e controle da doença. No entanto, desafios persistem, como a resistência adquirida aos tratamentos e os efeitos adversos imunomediados, ressaltando a importância da personalização terapêutica com base no perfil molecular do tumor e nas características individuais do paciente. Conclui-se que, apesar dos avanços, o melanoma metastático continua sendo um desafio clínico que exige abordagens terapêuticas cada vez mais refinadas. O desenvolvimento de novos ensaios clínicos e a investigação de biomarcadores preditivos são fundamentais para otimizar a eficácia dos tratamentos e reduzir os impactos da toxicidade. Dessa forma, a integração de terapias inovadoras e estratégias personalizadas pode representar um avanço significativo na melhoria dos desfechos clínicos e na sobrevida dos pacientes com melanoma metastático.
IMPACTO DO GLAUCOMA NA SAÚDE PÚBLICA: ANÁLISE EPIDEMIOLÓGICA (2014-2024)
Authors: Cardoso dos Santos Iasmin Carmo , Bedin Sarolli Maria Eduarda , Araujo Cardoso Joice , Dantas da Silva Gabriel Pinto , Barros Silva Yasmin , Lebram Martinelli Braga Maria Fernanda , Mota Miranda Sara da , Trindade Santos Pina Natalia , Da Silva Avelar Luanda , Macedo Silva Vinicius , Pinheiro Parnaíba Mirlandia , Araújo e Souza Sophia , Mascarenhas da Silva Priscilla , Mesquita Alves Costa João Pedro , Feitosa Syone de Jesus
Published: February 2025

Introdução: O glaucoma é uma das principais causas mundiais de perda irreversível da visão. É uma doença que causa neuropatia óptica progressiva e irreversível associadas a defeitos característicos do campo visual e alterações estruturais. Esta doença cursa com diminuição da acuidade visual e consequente declínio na qualidade de vida dos pacientes. Com isso, a identificação de fatores de risco e da doença em seu estágio inicial e o encaminhamento ágil e adequado para o atendimento especializado é essencial para um melhor resultado terapêutico e prognóstico dos casos. Objetivo: Este estudo tem como objetivo avaliar o perfil epidemiológico do glaucoma no Brasil, identificando a prevalência e a relevância do diagnóstico precoce, visando contribuir para estratégias de prevenção e manejo adequado da doença. Metodologia: Trata-se  de  um  estudo  epidemiológico,  retrospectivo  com  abordagem quantitativa e retrospectiva, com dados referentes à prevalência e impactos das internações no período de 2014 a 2024, nas cinco regiões brasileiras. Resultados: Das 60.903 internações analisadas, a maior concentração ocorreu nas regiões Sudeste (47%), já quanto ao sexo, há predominância de internações entre homens (52%) em relação às mulheres (47%). Com isso, dentre o número de internações, prevalece os casos de pacientes na senilidade, principalmente entre 60 a 69 anos. Em relação à cor/raça, a maioria das internações foi entre pessoas pardas (20.146 casos), seguidas por brancas (18.926 casos). Por fim, o ano de 2023 foi o que registrou o maior número de internações (9.149), seguido por 2022 (7.743 casos). Conclusão: Para a prevenção do glaucoma é imprescindível que os pacientes conheçam a doença e disponham de atendimento adequado para o diagnóstico precoce, trazendo a população para perto do oftalmologista. Portanto, para reduzir o índice de cegueira por esta patologia, a literatura sugere uma estratégia a ser desenvolvida com o intuito de estimular o diagnóstico precoce da doença na comunidade, incluindo o reconhecimento da dimensão do problema, a facilitação do acesso ao atendimento primário e educando a população sobre o glaucoma, seus fatores de risco, tratamento e consequências. Destacando, então, a importância de expor esse tema com maior frequência, buscando instigar o meio acadêmico e científico a aprimorar os conhecimentos acerca dessa problemática e conseguir um resultado efetivo ajudando a população a prevenir e tratar o glaucoma.
EFICÁCIA DO OCLACITINIB E DO LOKIVETMAB NO CONTROLE DA DERMATITE ATÓPICA CANINA: UM ESTUDO COMPARATIVO
Authors: Barreiro Luiza Fernandes Guimarães , Santos Maryane Gomes Marreiros dos , Silva Caroline Pena , Ramos Jéssica Vieira , Seilert Nadia dos Anjos , Cidral Letícia Orthey , Cauás Danila Duca , Gomes Letycia Vilela , De Souza Maileide Guimarães , Ferreira Ana Rogéria Andrade Oliveira , Costa Luana Henriques
Published: February 2025

A dermatite atópica canina (DAC) é uma condição crônica frequente que prejudica a pele canina, sendo afetada por elementos genéticos, ambientais e imunológicos. O objetivo deste estudo é comparar a eficácia do oclacitinib e do lokivetmab no controle da DAC, avaliando seu impacto no bem-estar dos cães e na qualidade de vida dos tutores. A metodologia adotada envolveu uma revisão narrativa da literatura, utilizando artigos em bases de dados como PubMed, ScienceDirect, Scielo e Google Scholar, utilizando termos ligados à dermatite atópica, oclacitinib, lokivetmab e qualidade de vida canina. Os resultados indicam que o oclacitinib proporciona um alívio imediato dos sintomas, com uma melhora notável em menos de 48 horas, ao passo que o lokivetmab oferece um alívio duradouro, com uso mensal. O estudo conclui que ambos os tratamentos possuem eficácia comprovada, porém apresentam variações na frequência de administração e no custo. O uso adequado de cada uma das medicações pode aprimorar o tratamento da enfermidade em questão e a qualidade de vida dos cães.
TRANSFORMING ANDHRA PRADESH INTO A GLOBAL TOURISM HUB: A STUDY OF TOURISM POLICIES INCLUDING THE NEW TOURISM POLICY 2024-29
Authors: D. Ramanjulu  , D. Krishnamoorthy
Published: February 2025

Andhra Pradesh has been recognized as a prominent tourist destination since India’s Independence. Over the decades, state governments, in alignment with central five-year plans and national tourism policies, have implemented various measures to enhance tourism infrastructure and increase tourist footfall. Following the bifurcation in 2014, the new Andhra Pradesh government introduced specific tourism policies that outlined a clear vision and mission for the tourism sector. Andhra Pradesh currently ranks third in domestic tourism, attracting 278 million domestic visits annually, along with 180,000 foreign visitors.
The Andhra Pradesh Tourism Policy 2024-29 aims to position the state as a leading global tourism destination by leveraging its rich cultural heritage, scenic landscapes, and spiritual landmarks. Recognizing tourism as an industry, the policy emphasizes economic growth, employment generation, and sustainable development. The "Swarna Andhra Tourism Vision 2047" envisions Andhra Pradesh as a world-class tourism hub, while the "Swarna Andhra Tourism Mission 2029" sets specific goals, such as increasing tourism's contribution to the state’s Gross Value Added (GVA) from 4.6% to 8% and its share in employment from 12% to 15%.
To support this vision, the policy introduces fiscal incentives, including tax benefits, land acquisition reimbursements, and capital subsidies for tourism projects. Infrastructure development, improved connectivity, and sustainable tourism practices are prioritized to enhance visitor experiences while preserving natural and cultural resources. Through these strategic measures, the Andhra Pradesh Tourism Policy 2024-29 aims to boost the state’s tourism potential, attract investments, and create a thriving tourism-driven economy.
KEYWORDS: A.P. Tourism. New tourism Policy, Industry status, Swarnandhra Tourism Mission
Stylistic Features of Paul Savatier’s Prose (Based on the Material of the Short Story “A Rendezvous at the Cafe de la Paix”)
Authors: Perkas L. S. , Pekarskaya I. V. , Shpomer E. A.
Published: February 2025

This article is devoted to the description of the stylistic features of P. Savatier’s prose based on the material of
the short story “A Rendezvous at the Cafe de la Paix”. The realized analysis allows us to conclude that the language of this work is distinguished by its figurativeness and expressiveness, which are achieved through the skillful use of the entire system of intensifiers
of figurativeness and expressiveness of speech, the use of elocutives of tropeic and figurative character, their contamination
(interimposition) and convergence (intersequence), both by the author of the short story and by the translator. The fundamental
figurative and expressive means that make up the figurative design of the text are epithet, metaphor, personification, rhetorical
question, gradation, inversion, as well as the interimposition and intersequence of intensifiers of verbal pragmatics.
Ideological Foundations of the Educational Process in the Siberian Cossack Army (Second Half of the 19th — Early 20th Century)
Authors: Grachev A. V. , Savoskina A. S.
Published: February 2025

The article is devoted to the analysis of the ideological foundations in school education in the Siberian Cossack Army
in the period from the middle of 19th to the early 20th century. During the study, the ideological components that are the basis of
training and education among the Siberian Cossacks were determined: religiosity, statism, monarchism, patriotism. The authors
identified the tools used to achieve the educational objectives. The article used historical sources that have not previously been
introduced into scientific circulation.