bluuebunny/crossref_metadata_2025 huggingface dataset:
A Clinical Study to evaluate the efficacy of Papaya Ksheera based Sphatika Ksharasutra in Bhagandara w.s.r. to fistula-in-ano
Authors: H Amulya , PN Shilpa , R Madhunayak
Published: July 2018

Background: Bhagandara is one among Ashtamahagadas mentioned by Acharya Sushruta and is one of the most common ailments pertaining to ano rectal region. Management of Fistula -in-ano has become a challenge to Allopathy Surgeons because of its complications like post-operative pain, wound management, recurrence and incontinence. In Ayurveda, the effective treatment is Ksharasutra ligation. Snuhi Ksheera based Apamarga Ksharasutra is the standard one and is proved effective treatment in the management of Fistula-in-ano. But, burning sensation, pain, local irritation during the course of therapy and difficulty in manufacturing process has limited its use. To overcome these lacunas, present study has been carried out. Objectives: To evaluate the significance of Papaya Ksheera based Sphatika Ksharasutra by comparing with the efficacy of Snuhi Ksheera based Apamarga Ksharasutra in the management of Bhagandara. Materials and methods: A total of 40 patients were randomly allotted into two groups namely Group A with trail drug i.e. Papaya Ksheera based Sphatika Ksharasutra and Group B as Control group i.e. Snuhi Ksheera based Apamarga Ksharasutra with 20 patients in each group. Results: Assessment of Pain, Discharge, Pruritis ani, length of track was made. In Group A, overall result is 98.5% and Group B overall result is 91.5%. The test shows that the treatment is statistically not significant in Group B when compared to Group A. Conclusion: This study showed that the trial drug was as effective as the standard drug in the treatment of Bhagandara.
Comparitive study of clinical effect of Apamarga Kshara Sutra prepared by 7 and 21 coatings in Bhagandara
Authors: K Shankaraprasad , Sharma Muralidhara , RN Rakesh
Published: July 2018

Bhagandara is a 2nd highest prevalent disease among the anorectal diseases. It can be correlated to Fistula-In-Ano. For the management of fistula in ano various surgical, parasurgical and minimally invasive surgical procedures have been mentioned. But all these procedures carry a disadvantage of high rates of recurrence and also have a great chance of creation of serious complications like anal incontinence and anal stenosis. Hence the search for a newer, safer and scientific treatment for the management of this disease continues. Objectives: A new Kshara Sutra with fewer coatings has been tried to see if results are the same with an advantage of early and easy preparation. Materials and Methods: Total 30 patients were randomly selected in the study and divided into 2 groups fulfilling the inclusion criteria which were designed for the study. Results: Study showed significant results in reducing the discharge, pain, itching and burning sensation and induration within the group and insignificant result obtained between the groups statistically. Conclusion: The study revealed that Kshara Sutra prepared with 7 coating is more economical, easy to prepare and equally efficient in the management of Bhagandara.
Effect of Haritaki (Terminalia Chebula Retz) with Takra in Dandruff
Authors: M Sreelekshmi , S. Vimala K. , Paul Raiby P.
Published: July 2018

Dandruff is a common scalp disorder affecting almost half of the population. According to Ayurveda, Dandruff may be correlated to Darunaka. Ayurveda classics dealt different procedures and medications to treat the disease Darunaka (dandruff). The present study is based on the reference from Cikitsamanjary by Sreeman Nambootiri, an authentic Ayurveda book. Haritaki mixed with Takra (buttermilk) as Sirolepa (application of paste over the scalp region) is used to reduce Darunaka. Darunaka is a Kapha Vata predominant disease having the symptoms like Kandu (Itching), Kesha Chyuthi (Hair fall), Twak sphutana (Scaling) and Rukshata (Dryness). Haritaki is having Lavanavarjitha Pancha Rasa, Laghu Ruksha Guna, Ushna Virya, Madhura Vipaka and Tridoshahara property (Pharmacological properties). Takram is having Laghu Ruksha Guna, Kasaya, Amla rasa; Ushna Virya and Madhura Vipaka with Kapha Vatahara property. In the clinical study, 30 patients of Darunaka were selected as per inclusion and exclusion criteria. The study was effective in reducing the symptoms of Darunaka.
A Pharmaceutico-Analytical Study of Bhunaga Satva
Authors: Patel Manish Kumar , . Archana , . Lalchand , Parhate Saroj
Published: July 2018

The knowledge of Tamra (copper) was known to Indians, since early ages of medical practice. It is having the Rasayana, emetic, purgative, blood purifying properties. Ashodhita Copper causes Vanti (vomiting) and Bhranti (mental illusion). So it should be used after Shodhana only. Various pharmaceutical procedures i.e. Shodhana (purification), Marana (incineration), Satvapatana (extraction of metal from mineral) etc. converts deadly toxic mineral, metallic substances into safe and potent therapeutic agent. Bhunaga (earthworm) Satva has been mentioned as a source of Tamra (copper). This paper aims to make available standard manufacturing process of Bhunaga Satva-Patana. Satvapatana process performed by method described in Rasa Tarangini. 2 gm of Satva was obtained from 120 gm of Bhunaga Masi. Percentage yield of Satva was 1%. The prepared Satva’s were subjected to qualitative and quantitative analysis. In Bhunaga there was Satva higher percent of Fe (75.3%) along with containing Cu 18.8% and Zn 2%.
Concept of Swastha Vrutta in Netra Swasthya
Authors: G Prakruthi , MD Visakh , V Hamsaveni
Published: July 2018

Acharya Chakrapani clearly says that the condition free from disease is Swastha and regimens followed to keep the individual healthy are Swastha Vrutta. Acharya Sushruta explains Swastha as a condition where there will be Sama Dosha, Sama Agni, Sama Dhatu, proper Mala Kriya, Prasanna Atma-Mana, which is even now accepted by WHO also where they defined health as a state of complete physical, mental and social well being and not merely the absence of disease or infirmity. Netra being the most important Indriya among all the Indriya, it is very necessary to maintain its health. Creating awareness among the people regarding the concepts of Dinacharya, Rutucharya, Sadvrutta helps to decrease the increasing life style diseases. The concept of Ahara is very much important when it comes to Dosha and Dhatu Samyata. Being Nayana Chintakas, it is our duty to explore the things which our Acharyas explained clearly to maintain Swasthya. In this aspect an attempt is made to gather the information which is specifically explained as a part of Swastha Vrutta in relation with Netra Swasthya.
Motivation Predicts Change in Nurses’ Physical Activity Levels During a Web-Based Worksite Intervention: Results From a Randomized Trial (Preprint)
Authors: Brunet Jennifer , Tulloch Heather E , Wolfe Phillips Emily , Reid Robert D , Pipe Andrew L , Reed Jennifer L
Published: July 2018

BACKGROUND

Low physical activity levels can negatively affect the health of nurses. Given the low physical activity levels reported by nurses, there is a clear need for brief and economical interventions designed to increase physical activity levels in this population. We developed a web-based intervention that used motivational strategies to increase nurses’ physical activity levels. The intervention provided the nurses with feedback from an activity monitor coupled with a web-based individual, friend, or team physical activity challenge.

OBJECTIVE

In this parallel-group randomized trial, we examine whether nurses’ motivation at baseline predicted changes in objectively measured physical activity levels during the 6-week intervention.

METHODS

The participants were 76 nurses (n=74, 97% female; mean age 46, SD 11 years) randomly assigned to 1 of 3 physical activity challenge conditions: (1) individual, (2) friend, or (3) team. The nurses completed a web-based questionnaire designed to assess motivational regulations for physical activity levels before the intervention and wore a Tractivity activity monitor before and during the 6-week intervention. We analyzed data using multilevel modeling for repeated measures.

RESULTS

The nurses’ physical activity levels increased (linear estimate=10.30, SE 3.15; P=.001), but the rate of change decreased over time (quadratic estimate=−2.06, SE 0.52; P<.001). External and identified regulations (ß=−2.08 to 11.55; P=.02 to .04), but not intrinsic and introjected regulations (ß=−.91 to 6.29; P=.06 to .36), predicted changes in the nurses’ physical activity levels.

CONCLUSIONS

Our findings provide evidence that an intervention that incorporates self-monitoring and physical activity challenges can be generally effective in increasing nurses’ physical activity levels in the short term. They also suggest that drawing solely on organismic integration theory to predict changes in physical activity levels among the nurses participating in web-based worksite interventions may have been insufficient. Future research should examine additional personal (eg, self-efficacy) and occupational factors (eg, shift length and shift type) that influence physical activity levels to identify potential targets for intervention among nurses.

CLINICALTRIAL

ClinicalTrials.gov NCT04524572; https://clinicaltrials.gov/ct2/show/NCT04524572
The Most-Cited Authors Who Published Papers in JMIR mHealth and uHealth Using the Authorship-Weighted Scheme: Bibliometric Analysis (Preprint)
Authors: Kan Wei-Chih , Chou Willy , Chien Tsair-Wei , Yeh Yu-Tsen , Chou Po-Hsin
Published: July 2018

BACKGROUND

Many previous papers have investigated most-cited articles or most productive authors in academics, but few have studied most-cited authors. Two challenges are faced in doing so, one of which is that some different authors will have the same name in the bibliometric data, and the second is that coauthors’ contributions are different in the article byline. No study has dealt with the matter of duplicate names in bibliometric data. Although betweenness centrality (BC) is one of the most popular degrees of density in social network analysis (SNA), few have applied the BC algorithm to interpret a network’s characteristics. A quantitative scheme must be used for calculating weighted author credits and then applying the metrics in comparison.

OBJECTIVE

This study aimed to apply the BC algorithm to examine possible identical names in a network and report the most-cited authors for a journal related to international mobile health (mHealth) research.

METHODS

We obtained 676 abstracts from Medline based on the keywords “JMIR mHealth and uHealth” (Journal) on June 30, 2018. The author names, countries/areas, and author-defined keywords were recorded. The BCs were then calculated for the following: (1) the most-cited authors displayed on Google Maps; (2) the geographical distribution of countries/areas for the first author; and (3) the keywords dispersed by BC and related to article topics in comparison on citation indices. Pajek software was used to yield the BC for each entity (or node). Bibliometric indices, including h-, g-, and x-indexes, the mean of core articles on g(Ag)=sum (citations on g-core/publications on g-core), and author impact factor (AIF), were applied.

RESULTS

We found that the most-cited author was Sherif M Badawy (from the United States), who had published six articles on JMIR mHealth and uHealth with high bibliometric indices (h=3; AIF=8.47; x=4.68; Ag=5.26). We also found that the two countries with the highest BC were the United States and the United Kingdom and that the two keyword clusters of mHealth and telemedicine earned the highest indices in comparison to other counterparts. All visual representations were successfully displayed on Google Maps.

CONCLUSIONS

The most cited authors were selected using the authorship-weighted scheme (AWS), and the keywords of mHealth and telemedicine were more highly cited than other counterparts. The results on Google Maps are novel and unique as knowledge concept maps for understanding the feature of a journal. The research approaches used in this study (ie, BC and AWS) can be applied to other bibliometric analyses in the future.
ASPECTOS ANTROPOLÓGICOS, BIOQUÍMICOS, MICROBIOLÓGICOS E CLÍNICOS DO CÁLCULO DENTÁRIO: UMA REVISÃO DA LITERATURA
Authors: Hirata Júnior Raphael
Published: July 2018

Resumo: O cálculo dentário é uma estrutura calcificada a partir do biofilme dentário (placa bacteriana) que, após o seu estabelecimento, é de difícil remoção e constitui um mecanismo de patogenicidade importante em diversas situações patológicas da cavidade oral por estar sempre coberto por uma camada viável de biofilme não mineralizada. A presente revisão de literatura releva a importância dos biofilmes calcificados nos contextos de doença, seus aspectos clínicos e microbiológicos em tempos anciães e contemporâneos, e sobre as medidas terapêuticas e preventivas. Apesar de todo conhecimento gerado sobre as doenças da cavidade oral, ainda são limitadas as abordagens clínicas a respeito dos mecanismos de controle dos cálculos dentários.Abstract: Dental calculus is a calcified structure from the dental biofilm (plaque), which, after its establishment, is difficult to remove and constitutes an important mechanism of pathogenicity in various pathological situations of the oral cavity because it is always covered by a viable layer of non-mineralized biofilm. The present literature highlights the importance of calcified biofilms in disease contexts, clinical and microbiological of dental calculus aspects in ancient and contemporary eras, and in therapeutic and preventive measures. Despite all the knowledge generated about the diseases of the oral cavity, the clinical approaches regarding the mechanisms of control of dental calculus still need investigations.Palavras Chave: Cálculo dentário, Calcificação do biofilme, Higiene oralKey words: Dental calculus, Biofilm calcification, Oral hygiene
CONTROLE COMPORTAMENTAL EM ODONTOPEDIATRIA COM O AUXÍLIO DE FÁRMACOS: QUANDO E COMO INDICAR.
Authors: Pinto Pimentel Thais
Published: July 2018

Palavras-chave: Odontopediatria; Controle Comportamental; Sedação ConscienteKeywords: Pediatric Dentistry; Behavior Control; Conscious Sedation
EPÍGRAFES BÍBLICAS EM MURILO RUBIÃO
Authors: Percino Eziel Belaparte
Published: July 2018

Este artigo investiga o problema das epígrafes bíblicas nos contos de Murilo Rubião. Recuperando os percursos históricos das epígrafes em textos literários, considera e avalia as epígrafes rubianas em termos de ornamento, busca de autoridade, referência, espelho temático, síntese, protocolo, efeito-fratura e interrogação. Enfim, propõe que, nas relações entre epígrafes e narrativas, significado e não-significado são apenas decisões pragmáticas talhadas pela singularidade de um encontro entre texto e leitor.
Nas cinzas da memória: a poeira da tradição
Authors: Chagas Silvania Núbia
Published: July 2018

Primeiro romance da trilogia As areias do imperador, “Mulheres de Cinza” (2015), de Mia Couto, é uma narrativa contada por dois narradores que se desdobram nas mais diversas formas de narrar, concentrando em si vários status. Para além disso, o discurso desses narradores é portador de um imaginário construído por meio de uma memória denominada por Jacques Le Goff (2003) como “memória artificial”, que hora nos remete ao narrador da tradição oral, ora ao narrador da modernidade. Um discurso que entrecruza “a letra e a voz”[1], forjando a oralidade por meio da escrita. Esse imaginário nos remete à trajetória do narrador desde a tradição oral, tão bem contemplado nos estudos de Walter Benjamin (1994), até o narrador da modernidade e seus desdobramentos.  Verificar como isso ocorre é o objetivo deste estudo.[1] Título de uma obra de Paul Zumthor.
Francesca Woodman e o assombro dos fantasmas modernos
Authors: Linhares Sanz Cláudia , De Souza Fabiane
Published: July 2018

Distraídos por tantas imagens do cotidiano, os fantasmas hoje mal nos assombram. Neste artigo, entendemos que a fotografia de Francesca Woodman, ao inquietar fronteiras − entre moderno e contemporâneo, presença e ausência, sentido e não sentido, brevidade e permanência − aprofunda o aspecto fantasmal das imagens, deixando comparecer os fantasmas da fotografia moderna, que até há pouco ainda nos assombravam. Na experiência contemporânea, esses fantasmas questionam a torrente de imagens e nos relembram de que no instante podem morar outros tempos, que duram na imagem. E assim, habitando diferentes tempos, entrelaçados às imagens de Woodman, convivem ecos da escritura de autoras como Clarice Lispector, Maria Gabriela Llansol e Ana Cristina César.
Mengatasi Perilaku Membolos Peserta Didik Menggunakan Konseling Individual
Authors: Busmayaril Busmayaril , Umairoh Efi
Published: July 2018

: Kegiatan layanan konseling dapat diselenggarakan baik secara perorangan maupun kelompok. Secara perorangan layanan konseling dilaksanakan melalui konseling individual, sedangkan secara kelompok melalui konseling kelompok. Konseling individual ditujukan kepada peserta didik untuk membantu memperbaiki kebiasaan yang kurang memadai/perilaku menyimpang (perilaku membolos) agar menjadi perilaku yang lebih baik lagi di lingkungan sekolah. Hasil survey pra penelitian yang penulis peroleh di Sekolah Menengah Atas (SMA) Pangudi Luhur Bandar Lampung menunjukkan bahwa masih terdapat peserta didik yang melakukan pelanaggaran tata tertib sekolah (membolos). Metode yang digunakan dalam penelitian ini yaitu penelitian lapangan (field research) dengan jenis penelitian deskriptif. Populasi dalam penelitian ini yaitu peserta didik kelas XI dan 1 guru bimbingan konseling, dari jumlah keseluruhan peserta didik kelas XI, penulis mengambil 7 peserta didik ditambah 1 guru bimbingan dan konseling untuk dijadikan sampel dalam penelitian ini. Teknik pengumpulan data menggunakan metode interview, observasi dan dokumentasi, sedangkan untuk menganalisis data digunakan metode analisis data yang bersifat kualitatif dengan menggunakan pendekatan berfikir induktif dan deduktif. Berdasarkan pengolahan dan analisis data yang penulis lakukan dalam skripsi ini diketahui bahwa pelaksanaan layanan konseling individual terjadi kebanyakan didasari atas inisiatif guru BK yaitu dengan cara memanggil peserta didik, selain itu kondisi sarana dan prasarana yang kurang memadai untuk melakukan konseling individual. Oleh karena itu guru BK harus menguasai pengetahuan bidang konseling teknik dan langkah-langkah yang akan dilaksanakan, sehingga pelaksanaan layanan bimbingan dan konseling individual di sekolah berjalan dengan baik dan maksimal.
The analysis of employment rates in the context of spatial connectivity of the EU regions
Authors: Chocholatá Michaela , Furková Andrea
Published: July 2018

Research background: The main objective of this paper is to analyse the employment rates in the context of spatial connectivity of the EU regions. Employment rate is declared as one of the important indicators of the strategic document Europe 2020. The achievement of high levels of employment in individual regions plays therefore an important role.

Purpose of the article: The aim of the paper is to verify the possible spill-over effects within the EU regions and their territorial interconnection in the context of employment rates.

Methods: Analysis is based on tools of the Exploratory Spatial Data Analysis (ESDA) to consider spatial connectivity of the EU regions.

Findings & Value added: The results show that the statistically significant clusters of regions with high employment rates are situated mainly in the central, northern and north-western part of the EU while the clusters with low values are located mainly in Greece, Spain, Italy, Portugal, Bulgaria, Romania and some French regions.
Spatial interdependence in property taxation: the case of Polish municipalities
Authors: Małkowska Agnieszka , Telega Agnieszka , Głuszak Michał , Marona Bartłomiej
Published: July 2018

Research background: Real estate and urban economics literature are abundant in studies discussing various types of property taxes and their characteristics. A growing area of re-search has been focused on tax equity, tax competition, and yardstick competition, where the latter two reflect the idea of tax mimicking. Recently, due to substantial developments in spatial and regional economics, more attention has been drawn to spatial effects. Empirical results are focused on spatial interaction and diffusion effects, hierarchies of place and spatial spillovers. Property tax system in Poland differs from those utilized in the majority of developed countries. As a consequence, property tax policy at the local government level (including tax competition and tax mimicking effects) in Poland can differ substantially from those found in previous research in the US and other European countries. There are few studies addressing the problem of tax competition and tax mimicking in Poland from an empirical perspective.

Purpose of the article: In the article, we explore spatial interdependence in property taxation. We identify clustering or dispersion of high and low values of the tax rates within major metropolitan areas in Poland. The effects can indicate the presence of tax mimicking among municipalities in given metropolitan areas.

Methods: We analyze the data from 304 municipalities in 10 metropolitan areas in Poland from the year 2007 to 2016. The data covers four property tax rates: (1) on residential buildings (2) on buildings used for business purpose (3) on land used for business purpose (4) on land for other uses. To explore the spatial distribution of rates, we used global and local spatial autocorrelation indicators (Moran?s I statistic and LISA).

Findings & Value added: The results suggest the presence of spatial correlation within metropolitan areas. We also found significant differences between metropolitan areas. The results of the study fill the gap in empirical research concerning property tax interdependencies and tax mimicking in Poland.
The main achievements of the EU structural funds 2007?2013 in the EU member states: efficiency analysis of transport sector
Authors: Melecký Lukáš
Published: July 2018

Research background: The European Union currently provides financial support to the Member States through various financial tools from European Structural and Investment Funds 2014?2020, and previously from the EU Structural Funds. In both terminologies, the funds represent the main instrument of EU Cohesion Policy to sustain territorial development, to increase competitiveness and to eliminate regional disparities. The overall impact of EU Funds depends on the structure of funding and absorption capacity of the country.

Purpose of the article: The efficiency of funding across the EU Member States is a fundamental issue for EU development as a whole. The Author considers deter-mining the efficiency of EU Funds as an issue of high importance, and therefore this paper provides a contribution to the debate on the role of EU Cohesion Policy in the Member States. The paper focuses on territorial effects of relevant EU Funds in programming period 2007?2013 in infrastructure through efficiency analysis.

Methods: Efficiency analysis is based on data at the country level, originating from ex-post evaluation of Cohesion Policy programmes 2007?2013 and representing the input and output variables to analyse whether the goal of fostering growth in the target countries have been achieved with the funds provided, and whether or not more resources generated stronger growth effects in transport accessibility. The paper deals with comparative cross-country analysis, descriptive analysis of dataset and multiple-criteria approach of Data Envelopment Analysis (DEA) in the form of output-oriented BCC VRS model of efficiency and output-oriented APM VRS subsequently model of super-efficiency.

Findings & Value added: The paper aims to test the factors of two inputs and five outputs, trying to elucidate the differences obtained by the Member States in effective use of the European Regional Development Fund and the Cohesion Fund in the transport sector. The paper determines if the countries have been more efficient in increasing their levels of competitive advantages linked with transport. Preliminary results reveal that most countries with a lower amount of funding achieve higher efficiency, especially countries in a group of so-called ?old EU Member States?, i.e. group EU15.
APPROACH TO IMPLEMENTATING PRO-ACTIVE MANAGEMENT OVER RESOURCES OF THE DEPARTMENTS OF CONSTITUENT ENTITIES OF THE TOURISM CLUSTER
Authors: Morozov Aleksandr Olegovich , Kravets Alla Grigorievna
Published: July 2018

The tourist cluster has recently occupied one of the central places in the socio-economic system of the region. The lack of efficient methodology of managing the resources of the regional constituent entities (using the example of housekeeping service of the hotel) is an unsolved problem. The existing methods of management are ineffective in the conditions of modern activity of the hotel. The proposed solution is to use pro-active resource management methodology. The pro-active management methodology includes the following models: management of the housekeeping personnel, management of the laundry, forecasting the housekeeping resource requirements, support for the management decisions made by the housekeeping service manager. The developed methodology is used as a basis for PaUR web-based automated system. Machine learning methods were used to implement the model of forecasting the need for housekeeping resources, the main advantage of which is the operational retraining of models required due to the rapidly changing situation in the operational activities of the hotels. The use of the proposed methodology allows increasing the labor productivity of housekeeping service personnel, reducing costs, as well as using an open and effective system of staff motivation.
Comparative planning and housing studies beyond taxonomy
Authors: Tulumello Simone , Ferreira Ana Catarina , Colombo Alessandro , Di Giovanni Caterina Francesca , Allegra Marco
Published: July 2018

Recent European comparative studies in the fields of housing policy and spatial planning have been dominated by taxonomical and linear approaches, and by normative calls for convergence toward systems considered more ‘mature’ or ‘advanced’. In this article, we adopt a genealogical perspective and consider those cultures that are central to the shaping of policy. We set out a long-term exploration of the intersection between spatial planning and housing policy in Portugal and focus on the Special Programme for Rehousing (Programa Especial de Realojamento, PER), a programme that has had changing roles (from a financial instrument to a core component of policies of urban regeneration) in connection with political and planning cultures changing in time and space. In this way, we provide evidence of the limited capacity of taxonomic and linear approaches to describe planning and housing systems undergoing processes of change and, conversely, show the potential of genealogical research.
Tourism identity in social media
Authors: Kim Joon Sik , Wang Yi-Wen
Published: July 2018

In the context of tourism planning and promotion, there is wide acknowledgement that conceptualisations of tourism identity cannot be grounded merely in physical place, but should also encompass a wide range of factors including, for instance, cultural relations, tourist activities, and social networking. There are opportunities in late modern society for relating the identity of a city’s tourism with digitally-presented tourists’ perceptions and activities through social media studies. This research explores multiple research approaches to delineate the digital identity of Suzhou’s tourist destinations, as presented in online user-generated contents. It is hoped that this social media study can provide supplementary information for tourism bureaus and agencies to make informed judgements on effecting pertinent improvements to optimise existing tourism resources and create more enticing environments for tourists. The research follows a case study approach and conducts an empirical study on Suzhou, a Chinese historic city. The analysis of the results show that the social media study is potentially useful in identifying the key characteristics of particular tourist destinations from visitors’ perspectives that may also be helpful for the evaluation of tourists’ experiences.
Platelet miRNA-26b down-regulates multidrug resistance protein 4 in patients on chronic aspirin treatment
Authors: La Rosa Giulio , Biasucci Luigi M. , Mandolini Claudia , Massimi Isabella , Copponi Giorgia , Pulcinelli Fabio M. , Crea Filippo
Published: July 2018

Background

Multidrug resistance protein-4 (MRP4) is an ATP binding cassette membrane transporter, actively involved in the efflux of important pharmacological and physiological molecules. Recently, its over-expression has been associated with reduced aspirin (ASA) efficacy after by-pass surgery. MicroRNAs (miRNAs) are small molecules of non-coding RNA involved in the regulation of many physiological and pathophysiological pathways, are abundant in platelets, and can be modulated by several drugs. In the present study, we assessed the role of platelet miRNAs in modulating MRP4 function in response to ASA.

Methods

MRP4 mRNA expression has been analyzed by RealTime PCR in platelets from patients on chronic ASA treatment versus a control group. A panel of miRNAs was run on the pool of each cohort. MiRNAs validation was performed by RealTime PCR. To verify whether MRP4 is the target of miR-26b also in platelets, miR-26b was transfected in platelet and DAMI cells with miRNA mimic technology. MRP4 expression was evaluated by flow cytometry and western blotting.

Results

We observed a higher MRP4 mRNA expression in platelets of patients under ASA treatment compared to the control group (p<0.005). MiR-26b was found significantly down-regulated in patients on ASA treatment as compared to control group (P < 0.005) and this was validated by RealTime PCR. MiR-26b transfection in platelets was associated to a significant down-regulation of MRP4 expression (p<0.005). MiR-26b transfection in DAMI cells was associated to a significant reduction of MRP4 mRNA and protein level (P < 0.05).

Conclusion

We found that miR-26b is down-regulated in platelets in patients on chronic ASA treatment. Importantly, miR-26b can specifically downregulate MRP4. Thus, miR-26b seems to be involved in MRP4 modulation and may contribute to ASA resistance.
ЭКОСИСТЕМА ЛАДОЖСКОГО ОЗЕРА: СОВРЕМЕННОЕ СОСТОЯНИЕ И ТЕНДЕНЦИИ ЕЕ ИЗМЕНЕНИЯ В КОНЦЕ XX – НАЧАЛЕ XXI В.
Authors: Курашов Е.А. , Барбашова М.А. , Дудакова Д.С. , Капустина Л.Л. , Митрукова Г.Г. , Русанов А.Г. , Алешина Д.Г. , Иофина И.В. , Протопопова Е.В. , Родионова Н.В. , Трифонова М.С.
Published: July 2018

Особое значение для всего региона Северо-Запада имеет крупнейшее в Европе озеро Ладожское. Постоянное слежение за его экологическим состоянием жизненно необходимо для решения самых разнообразных задач научного и практического характера. Цель публикации – на основании комплексных исследований основных биологических сообществ Ладожского озера (фитопланктон, макрофиты, водные грибы, бактериопланктон, зоопланктон, макро- и мейобентос) представить информацию по его современному экологическому состоянию и описать изменение экосистемы озера в конце XX – начале XXI в. Объединенные данные по всем основным гидробиологическим сообществам на основании исследований последнего десятилетия (2007–2017 гг.) позволяют заключить, что трофический статус центральной части акватории Ладожского озера оценивается как слабомезотрофный (при олиготрофном характере гиполимниона), северной – как олиготрофный, западной – как мезотрофный, южной части (Свирская и Волховская губы) – как слабоэвтрофный. Средние величины биомассы фитопланктона и хлорофилла-а позволяют охарактеризовать Ладожское озеро в целом как мезотрофный водоем. Для литоральной зоны озера наиболее значимой является трансформация биоценозов, вызываемая популяциями видов-вселенцев. В целом современное состояние озера может быть охарактеризовано как благоприятное. При этом в настоящее время вектор развития его экосистемы определяется, в основном, естественными факторами природной среды в конкретных климатических условиях. Вместе с тем подчеркивается, что ни в коем случае нельзя допускать увеличения антропогенной нагрузки на озеро, его загрязнения, поскольку этот огромный водоем имеет большую инерционность, и если произойдет сдвиг в его экологическом состоянии в худшую сторону, то возврат озера в благоприятное состояние при принятии даже всех необходимых мер займет не менее 2–3 десятилетий.
СОВРЕМЕННАЯ КОНЦЕПЦИЯ И МЕТОДЫ НОРМИРОВАНИЯ ТЕХНОГЕННОЙ НАГРУЗКИ НА ВОДНЫЕ ОБЪЕКТЫ И ПРЕДОТВРАЩЕНИЯ ПОДТОПЛЕНИЯ
Authors: Шишкин И.А. , Шишкин А.И. , Жильникова Н.А.
Published: July 2018

Рассмотрены принципы, методы и средства реализации современной концепции эколого-технологического нормирования техногенной нагрузки на водные объекты и их экологические системы, а также алгоритмы оценки уровней безопасности и ущерба от подтопления градопромышленных территорий и хозяйственных объектов. Особое внимание уделено экологическому управлению территориальными природно-техническими комплексами на основе межотраслевого подхода с учетом большого многообразия и сложности разнородных определяющих факторов, а также учету труднопредсказуемых событий, основанному на математическом геоинформационном моделировании. Приняты во внимание наиболее важные параметры водного режима, в том числе его распределение во времени и пространстве, скорость продукционных процессов, деструкция органического вещества, флоры и фауны гидробионтов и, как следствие, общее состояние качества воды и биопродуктивность водных экосистем. Их оценка с применением математических моделей конвективно-диффузионного переноса и превращения веществ позволяет определить их непосредственное или опосредованное, быстрое или отсроченное влияние на абиотические и биотические компоненты водных экосистем.
NHÂN GIỐNG IN VIVO CÂY BÁCH BỆNH (EURYCOMA LONGIFOLIA JACK)
Authors: Đức Trần Minh , Yến Văn Thị , Hợi Nguyễn , Lan Phạm Thị Ngọc
Published: July 2018

Tóm tắt: Bài báo này trình bày các nghiên cứu về nhân giống cây bách bệnh (Eurycoma longifolia Jack) bằng kỹ thuật giâm hom và gieo hạt. Hom giâm trước khi xử lý chất kích thích sinh trưởng đã được ngâm trong dung dịch diệt nấm Benlat-C 0,1 %. Kết quả cho thấy sau 4 tháng hom giâm bắt đầu nảy chồi và sau 6 tháng đã xuất hiện rễ. Trong đó, xử lý bằng Auxin Indole acetic acid (IAA) nồng độ 1250 mg/L cho kết quả tốt nhất đối với hom đầu ngọn (23,45 % nảy chồi và 5,56 % xuất hiện rễ), IAA nồng độ 1000 mg/L thích hợp cho hom đoạn thân (51,84 % nảy chồi và 52,22 % xuất hiện rễ). Ở trường hợp gieo hạt, tỉ lệ nảy mầm cao nhất đạt được đối với hạt có độ thuần 78 % sau 30 ngày gieo là 28 % khi được xử lý nhiệt trong khoảng 40–45 °C trong 8 giờ. Giá thể có thành phần 89 % đất cát + 10 % phân chuồng + 1 % lân cho kết quả cao nhất về tỷ lệ sống, chiều cao và đường kính gốc lần lượt là 100 %, 7,98 cm và 0,27 cm.Từ khóa: bách bệnh, giâm hom, gieo hạt, nhân giống
NGHIÊN CỨU XÂY DỰNG BẢNG MÔ TẢ TÍNH TRẠNG CỦA CÂY SÂM NGỌC LINH TẠI HUYỆN NAM TRÀ MY TỈNH QUẢNG NAM
Authors: Hải Trương Thị Hồng , Thắng Trần Viết , Phước Nguyễn Đức , Tư Võ Văn
Published: July 2018

Tóm tắt: Trong bài báo này, chúng tôi trình bày kết quả nghiên cứu mô tả tính trạng cây Sâm Ngọc Linh 4 và 5 tuổi nhằm tạo lập vườn cây giống gốc để phục vụ công tác bảo tồn nguồn gen và sử dụng khai thác sản xuất cây giống chất lượng cao đáp ứng tốt nhu cầu của thực tế sản xuất tại huyện Nam Trà My, tỉnh Quảng Nam. Cây Sâm Ngọc Linh có 1 thân và đặc điểm cây 4 tuổi và 5 tuổi có nhiều khác biệt về hình thái bên ngoài và kích thước thân lá cũng như củ. Cây Sâm Ngọc linh 4 tuổi có thân lá nhỏ hơn cây 5 tuổi, chùm hoa chưa thể hiện đặc trưng của giống là hình rẻ quạt. Sắc tố anthocyanin phân bố ở đỉnh thân. Cây Sâm Ngọc Linh 5 tuổi thể hiện tốt các đặc trưng của giống, thân lá to, cụm hoa phát triển đầy đủ có hình rẻ quạt, không có sắc tố anthocyanin trên thân. Vì vậy, nên sử dụng cây Sâm Ngọc Linh 5 tuổi trở lên để nghiên cứu các đặc điểm hình thái điển hình cho loài Sâm Ngọc Linh.Từ khóa: Cây Sâm Ngọc Linh 4 tuổi, cây Sâm Ngọc Linh 5 tuổi, xã Trà Linh, anthocyanin
Definiendo a las víctimas del terrorismo
Authors: Cortés Sánchez Linda Marcela
Published: July 2018

Si el terrorismo afecta derechos de las personas, los derechos de las víctimas son un elemento crucial a considerar para normalizar un país después de una crisis. Sin embargo, definir qué es una víctima de terrorismo era una tarea prioritaria antes que ninguna otra consideración, debido a los vacíos de una definición consensual de víctimas a través de los conceptos legales de terrorismo. Es obvio decir quién es víctima del terrorismo después de ver en las noticias la destrucción que causan las bombas, pero es la retórica política la que define quién puede considerarse víctima. No es lo mismo una víctima de un bombardeo en Libia que una víctima del conflicto armado en Colombia donde se usan las violaciones masivas a derechos humanos como método terrorista. Estos ejemplos muestran que definir víctimas de terrorismo requiere un diálogo y un acuerdo político porque es un dilema, a su vez, definir qué es terrorismo. Esta pieza de investigación analiza diferentes definiciones de la legislación internacional y doméstica, incluyendo la que aporta la salud pública, una de las más pertinentes. En sí, pretende demostrar los desafíos que presenta el derechoantiterrorista como nueva rama del derecho internacional al cambiar lentamente y bajo la retórica política las nociones básicas del derecho internacional humanitario.
Derechos económicos, sociales y culturales más vulnerados a personas en situación de desplazamiento
Authors: Torres Cetina Carlos
Published: July 2018

El presente artículo tiene como finalidad reflexionar so- bre los derechos económicos, sociales y culturales (desc), unos de los más vulnerados a las personas en situación de desplazamiento en Colombia; se tendrán en cuenta los re- portes de organizaciones especializadas en el tema, como el Departamento para la Prosperidad Social (dps) y la Consultoría para los Derechos Humanos y el Desplaza- miento (codhes). Se busca conocer y describir en qué consisten los desc, su importancia para una vida digna, y cómo en situación de desplazamiento las personas están sujetas a nuevas di- námicas en sus vidas, que hacen que adopten otro tipo de acciones y actividades que no eran propias de su cotidia- nidad. This article aims to reflect on what are the Economic, So- cial and Cultural most violated of people in situation of displacement in Colombia, will take into account reports from organizations such as the Department for Social Prosperity (dps) and the consultancy for Human Rights and Displacement (codhes), organizations specializing in this subject. This article seeks to understand and describe what these desc and their importance for a decent life for each per- son, and how as displaced persons are subject to new dy- namics in their lives causing them to take other actions and activities that were not typical of everyday life.
El proceso presupuestal territorial en Colombia
Authors: Sánchez Cubides Pedro
Published: July 2018

El presente artículo pretende identificar y analizar el ci- clo presupuestal que llevan a cabo los entes territoriales (departamentos, distritos y municipios) en Colombia, el cual incluye las fases de programación y preparación del proyecto de presupuesto; presentación del proyecto de presupuesto a la Asamblea o Concejo, según el caso; es- tudio y aprobación por parte de la corporación político- administrativa, ejecución y control del presupuesto.
Relaciones y tensiones entre la etnoeducación y los saberes y las prácticas de los indígenas curripacos
Authors: López Meneses Matilde , Gutiérrez Fuenmayor Luisa Fernanda
Published: July 2018

El objetivo del estudio fue analizar las relaciones y tensiones entre las prácticas de la etnoeducación y las formas de transmisión de saberes de los indígenas curripacos y cómo se articulan en los procesos etnoeducativos en la institución educativa Filintro, de la comunidad de Sabanitas. La investigación se enmarca dentro del enfoque epistemológico hermenéutico, y hace uso del método narrativo a través del diario de campo y la entrevista semiestructurada. Los resultados permiten ver que hay relación entre la etnoeducación y la transmisión de saberes ancestrales, y que ambas suponen un esfuerzo en aportar a la educación pra la diversidad y la pervivencia cultural. Sin embargo, se evidencian las tensiones entre la etnoeducación como política escrita y la
falta de aplicabilidad en la práctica y entre los saberes ancestrales y su articulación en la etnoeducación.
Educación en Colombia: tensiones de la educación privada vs la estatal
Authors: Gómez Murcia Rosa Helena
Published: July 2018

En la actualidad se evidencian diferencias entre el proceso educativo de las instituciones privadas y el de las estatales. Igualmente, hay tensiones entre las oportunidades que tienen los docentes y los educandos frente a la calidad educacional y calidad de vida que brindan estos dos regímenes de educación. Teniendo en cuenta lo anterior, es importante conocer las diferentes tensiones que se presentan entre los docentes y educandos de estos dos tipos de instituciones –privadas y estatales–. A través del estudio de diferentes documentos sobre los aportes teóricos e hipotéticos sobre las tensiones en la educación, sometidos a análisis constante con el fin de brindar a los maestros una idea clara sobre las fortalezas y debilidades que se presentan en los dos estados de la educación, se efectúa, asimismo, el estudio de diferentes autores que reconocen el nivel de importancia del tema. En conclusión, se logró conocer algunas de las tensiones que con más frecuencia se viven en el desarrollo de los procesos educativos y la influencia de estos sobre los docentes y educandos.
The Development of MANSAE as a Learning Media of Accounts for Vocational School Student of Accounting Program
Authors: Firdausi Devi Nur Rahmawati , Andayani Endang Sri
Published: July 2018

The objective of this research is to develop MANSAE (Making Accounting Newbies to Study Accounts Easily) as accounts learning media for accounting student of Vocational High School. MANSAE contains terms of accounts in Indonesian and English, normal balance of accounts, groups of accounts, classification of accounts in financial statement, and effect of service entity's financial transaction to accounts changes. This research uses Research and Development (R & D) method adapted from Borg & Gall’s. These method are needs analysis, product development, expert validation, product revision I, try-out (small scale), product revision II, and final product. . Product validation was  done by  media expert and content expert, while try-out was done by 10th grade of Accounting in SMKN 1 Turen. MANSAE get 97,61% from media expert, 88,70% from content expert, and 95,50% from limited user. The mean  is 93,94%, it means that from technical side, surface features, language and grammar, subject matter, and offline material is appropriate and suitable to use as accounts learning media for accounting newbies.

Keywords: media, mansae, account, account dictionary
The Implementation of Project-Based Learning to Improve the Learning Interest and Student Achievement
Authors: Fauzia Hamida , Prastiti Sawitri Dwi
Published: July 2018

The purpose of the research is project based learning model to improve student interest and achademic achievment of second grade of Social departement of State Senior High School 3 Blitar Through the implementation of project-based learning model. The research design is a Classroom Action Research (CAR) also using achademic achievment test and observation instruments. The research shows that the students learning interest and achademic achievment can be improved.

Keywords: Project-Based Learning Model, Learning Interest, Achademic Achievment
MENTORING IN A MODERN SCHOOL: MYTH OR REALITY?
Authors: Ignatieva E. V. , Bazarnova N. D.
Published: July 2018

Introduction:the modern education system presupposes certain mechanisms for the entry of a young specialist into the profession, rendering assistance to him at the initial stage of his professional development. Effective adaptation of a young specialist to the conditions of an educational organization is possible when organizing an effective model of mentoring in this organization. The article examines in detail the phenomenon of mentoring, as well as the results of a study on determining the state of mentoring in general schools in the city of Nizhny Novgorod.

Materials and methods:when writing the article, methods of analysis of domestic and foreign literature, comparative analysis, questioning, statistical methods of information processing were used.

Results:he article contains the results of a questionnaire survey conducted among the teachers of schools in Nizhny Novgorod and the Nizhny Novgorod region to determine the state of mentoring in modern schools. The results of this study prove the low awareness of the teachers of educational organizations about the functional of the mentor, and also demonstrates that the culture of mentoring should be supported and developed.

Discussion and Conclusions:the culture of mentoring provides a great potential for the development of teacher-mentors and young professionals, and also contributes to the greatest success of the educational organization.
EMOTIONAL INTELLIGENCE OF HR-MANAGEMENT STUDENTS
Authors: Grishina A. V. , Isaeva O. M. , Savinova S. Yu.
Published: July 2018

Introduction:Emotional intelligence is one of the key abilities of the modern managers and HR managers. Efficiency of the employees and the employer's brand depend on the level of HR‘s emotional intelligence. In this study we tried to assess the level of emotional intelligence among students studying Human Resources Management at HSE in Nizhny Novgorod. The study involved 78 students: 56 people (71.79% of the total sample) were undergraduate students and 22 people (28.21% of the total sample) were master level students.

Materials and methods:To measure the level of emotional intelligence we used the Test of emotional intelligence, developed by Professor E.A.Sergienko and E. A. Hlevnaya on the basis of the theoretical model of emotional intelligence as the ability of Mayer, J.D., Salovey, P. and Caruso, D.R.

Results:According to the results, the average values of general emotional intelligence and the main scales of emotional intelligence are at the level of competence. The highest rate is observed on the scale of the Emotion Management (M=102.46). Lower indicators characterize the scale of the Use of emotions (M=95,61). 64.10% of the respondents are characterized by an average level of the development of the ability to understand and rule emotions; 56.41% of students have a high level of development of the ability to perceive, identify their emotions and emotions of the others; 38.46% have a low level of development of the ability to use emotions to solve problems. The growth of indicators of emotional intelligence from Bachelor to Master Degree in all branches of emotional intelligence is noted.

Discussion and Conclusions:This article is largely a statement of the problem of emotional intelligent research and development of - HR-management students in terms of their professional training, development the professional competencies.