bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Masyarakat dalam Menarik Minat Kunjungan Wisatawan: Studi di Kampung Adat Prailiu Kabupaten Sumba Timur
Authors: Afifa Putri Nur Aini , Nugroho M. Setyo
Published: August 2022

This study aims to find out how the role and strategy of traditional village community prailiu attract  tourist visit interest in east sumba regency. This study uses descriptive qualitative approach with three data collection techniques. First, field observation in traditional village Prailiu. Second, Interview with informants (pusposive sampling). Third, documentation that is related to traditional village prailiu. Data analysis technique uses SWOT analysis to formulate traditional village community strategy prailiu in attracting tourist visit interest in east sumba regency. This study shows that traditional village community has firm desire and commitment in developing tourism village. Then, there are a number of alternative strategies that have been formulated to attract tourist visit interest based on SWOT analysis namely : (1) S-O strategy such as tourism product development, Having a partnership with sector private, Increasing production quality of Tenun (woven fabric), increasing promotion and marketing. (2) S-T strategy such as making tourism package and conducting strengthen product packaging. (3) W-O strategy such as developing SDM, having partnership between woven fabric craftsman and expanding woven fabric marketing network. (4) W-T Strategy such as constructing public awareness,  making serftification CHSE, providing health protocol training and providing training about tourism village management.
Akut Kalp Yetersizliğinde İlk 30 Dakika İçinde Nitrat ve Diüretik Tedavileri: Acil Serviste Kesitsel Bir Çalışma
Authors: ÇATAL Emre , ACAR Nurdan , ÖZAKIN Engin , ÇANAKÇI Mustafa Emin , DOLGUN Hakan , MOGHANCHİ ZADEH S. Hamed , MURAT Selda , ÇAVUŞOĞLU Yüksel
Published: August 2022

Akut Kalp Yetmezliğinin (AKY) tedavisinde diüretikler ve nitratlar, acil tedavinin temel taşını oluşturur ve yakın zamanlarda, bazı gözlemsel çalışmalar, 'zaman' kavramının önemini vurgulamıştır. AKY bulunan, erken diüretik ve nitrat uygulaması gerektiren hastaların klinik belirtilerini, fenotiplerini ve sonuçlarını araştırmayı amaçladık. Acil servise akut kalp yetmezliği belirti ve bulguları ile başvuran hastalar çalışmaya dahil edildi. Erken (30 dakika ve altı) ve gecikmeli (30 dakika üzeri) tedavi gruplarının klinik özellikleri diüretik ve nitrat tedavisinin süresine göre değerlendirildi. 719 hastanın medyan yaşı 73 idi [66-80 IQR] ve 395'i (%54.9) erkekti. 682 (%94,9) hastaya furosemid tedavisi, 537 (%74,7) hastaya gliserol trinitrat tedavisi verildi. Hem furosemid hem de nitratın erken tedavisini alan hastalarda hastane içi ölüm oranları yüksekti (OR: 5.802, %95 GA: 1.885-17.831, p = 0.001 ve OR: 5.229, %95 GA: 1.355–20.115, p = 0.013 , sırasıyla). Erken furosemid tedavisi alan hastalarda 3 aylık mortalite oranları da yüksekti (OR: 1.864, %95 GA: 1.078–3.223, p = 0.026). Erken dönemde (<30 dk) diüretik ve nitrat başlanan hastaların acil serviste kalış süreleri daha kısaydı. Hastane içi mortalite erken tedavi grubunda daha yüksekti.
Jadwiga Winklerowa (1920-1987) – the creator of Wrocław physical medicine
Authors: Kierzek Andrzej , Gil Ewelina
Published: August 2022

We wspomnieniu przedstawiono drogę życiową, zawodową i naukową Jadwigi Winklerowej (1920-1987), znanego wrocławskiego lekarza specjalisty balneoklimatologii i medycyny fizykalnej, internisty i reumatologa, pionierkę lecznictwa fizykalnego we Wrocławiu. Na wstępie ukazano jej działalność konspiracyjną w czasie drugiej wojny światowej. Była kierownikiem przychodni fizykoterapii i balneoklimatologii Wojewódzkiego Szpitala Zespolonego, konsultantem wojewódzkim do spraw medycyny fizykalnej i balneoklimatologii dla Wrocławia i województwa wrocławskiego, członkiem Zarządu Głównego Polskiego Towarzystwa Balneologii, Bioklimatologii i Medycyny Fizykalnej. Od podstaw stworzyła Oddział Wrocławski Polskiego Towarzystwa Balneologii, Bioklimatologii i Medycyny Fizykalnej, piastując stanowisko przewodniczącej do końca swoich dni. Wyspecjalizowała z medycyny fizykalnej ponad trzydziestu lekarzy różnych specjalności, niezliczone rzesze techników fizjoterapii. Współpracowała z uzdrowiskami Dolnego Śląska, organizowała liczne naukowe konferencje i sympozja. Znana jest jej działalność filantropijna. Była lekarzem o wysokim morale.
Contribution of the auxiliary research staff and technicians to the launch of chemical departments and labs of the Pharmaceutical School of Poznan University at the second floor of the building called Collegium Chemicum, Grunwaldzka Street 6, in 1945
Authors: Szmytówna Maria
Published: August 2022

Opublikowano wspomnienia prof. Marii Szmytówny (1903-1986), długoletniej kierownik Katedry i Zakładu Chemii Nieorganicznej i Analitycznej Wydziału Farmaceutycznego Akademii Medycznej w Poznaniu, o usuwaniu zniszczeń wojennych w pomieszczeniach zakładów farmaceutycznych znajdujących się w Collegium Chemicum w Poznaniu. Budynek został zbombardowany przez aliantów w 1944 r., ponieważ znajdowało się w nim dowództwo niemieckiego lotnictwa, a w laboratoriach produkowano deuter. Po kilku tygodniach odgruzowywania i naprawieniu najpilniejszych usterek, rozpoczęto zajęcia dydaktyczne.
Instantaneous Quantum Description of Photonic Wavefronts and Applications
Authors: Vatarescu Andre
Published: August 2022

Three physical elements are missing from the conventional formalism of quantum photonics: 1) the quantum Rayleigh spontaneous and stimulated emissions; 2) the unavoidable parametric amplification; and 3) the mixed time-frequency spectral structure of a photonic field which specifies its duration or spatial extent. As a single photon enters a dielectric medium, the quantum Rayleigh scattering prevents it from propagating in a straight-line, thereby destroying any possible entanglement. A pure dynamic and coherent state composed of two consecutive number states, delivers the correct expectation values for the number of photons carried by a photonic wave front, its complex optical field, and phase quadratures. The intrinsic longitudinal and lateral field profiles associated with a group of photons for any instantaneous number of photons are independent of the source. These photonic properties enable a step-by-step analysis of the correlation functions characterizing counting of coincident numbers of photons or intensities with unity visibility interference, spanning the classical and quantum optic regimes
A Blockchain-based Edge Computing Architecture for the Internet of Things
Authors: Tošić Aleksandar , Vičič Jernej , Burnard Michael David , Mrissa Michael
Published: August 2022

The Internet of Things (IoT) is experiencing widespread adoption across industry sectors ranging from supply chain management to smart cities, buildings, and health monitoring. However, most software architectures for IoT deployment rely on centralized cloud computing infrastructures to provide storage and computing power, as cloud providers have high economic incentives to organize their infrastructure into clusters. Despite these incentives, there has been a recent shift from centralized to decentralized architecture that harnesses the potential of edge devices, reduces network latency, and lowers infrastructure cost to support IoT applications. This shift has resulted in new edge computing architectures, but many still rely on centralized solutions for managing applications. A truly decentralized approach would offer interesting properties required for IoT use cases. To address these concerns, we introduce a decentralized architecture tailored for large scale deployments of peer-to-peer IoT sensor networks and capable of run-time application migration. The solution combines a blockchain consensus algorithm and verifiable random functions to ensure scalability, fault tolerance, transparency, and no single point of failure. We build on our previously presented theoretical simulations with many protocol improvements and an implementation tested in a use case related to monitoring a Slovenian cultural heritage building located in Bled, Slovenia.
Dynamic Asymmetric Effect of Currency Risk Pricing of Exchange Rate on Equity Markets: A Regime-Switching based C-Vine Copulas Method
Authors: Muteba Mwamba John Weirstrass , Mudiangombe Mudiangombe Benjamin
Published: August 2022

This paper investigates whether currency risk is priced differently in the different sectors (industrial, financial, and basic materials) of equity markets in a sample of developed United States of America (USA) and developing economies (Brazil, India, Poland, and South Africa). The paper makes use of the following techniques: (i) Univariate Autoregressive Fractionally Integrated Moving Average and Exponential General Autoregressive Conditional Heteroskedastic (ARFIMA-EGARCH), (ii) the Markov-Switching method (MS), and (iii) the Canonical Vine Copulas (C-Vine) techniques. Using a sample of daily data made of the foreign exchange rate against the domestic currency and equity market sectors; our findings show that there is an asymmetry effect between equities markets and the foreign exchange rate: there is a heterogeneous, strong, and positive dependence between the two. Higher equities prices are associated with depreciation of local currencies, according to US dollar (USD) exchange rates. In addition, we find that the selected emerging economies are pricing a positive and considerable currency risk. The pricing of currency risk has a varied effect in both regimes representing the states of the economy. In fact, when currency risk pricing has a beneficial impact on certain sectors of the economy, investors predict better returns.
An Ontological Knowledge Base of Poisoning Attacks on Deep Neural Networks
Authors: Altoub Majed , AlQurashi Fahad , Yigitcanlar Tan , Corchado Juan , Mehmood Rashid
Published: August 2022

Deep neural networks (DNN) have successfully delivered a cutting-edge performance in several fields. With the broader deployment of DNN models on critical applications, the security of DNNs becomes an active and yet nascent area. Attacks against DNNs can have catastrophic results, according to recent studies. Poisoning attacks, including backdoor and Trojan attacks, are one of the growing threats against DNNs. Having a wide-angle view of these evolving threats is essential to better understand the security issues. In this regard, creating a semantic model and a knowledge graph for poisoning attacks can reveal the relationships between attacks across intricate data to enhance the security knowledge landscape. In this paper, we propose a DNN Poisoning Attacks Ontology (DNNPAO) that would enhance knowledge sharing and enable further advancements in the field. To do so, we have performed a systematic review of the relevant literature to identify the current state. We collected 28,469 papers from IEEE, ScienceDirect, Web of Science, and Scopus databases, and from these papers, 712 research papers were screened in a rigorous process, and 55 poisoning attacks in DNNs were identified and classified. We extracted a taxonomy of the poisoning attacks as a scheme to develop DNNPAO. Subsequently, we used DNNPAO as a framework to create a knowledge base. Our findings open new lines of research within the field of AI security.
Neural Induction: the General Principle for Embryogenesis and Tumorigenesis
Authors: Cao Ying
Published: August 2022

Some concepts/hypotheses have been proposed to explain the general rules behind the complexity of tumorigenesis. Characterization of the property of cancer cells and neural stem cells indicates that neural stemness underlies tumorigenicity and pluripotency, leading to the proposal that tumorigenesis represents a process of progressive loss of original cell identity and gain of neural stemness. This reminds of a most fundamental process required for the development of the nervous system and body axis during embryogenesis, i.e., embryonic neural induction. The principle of neural induction is that, in response to extracellular signals that are secreted by the Spemann-Mangold organizer in amphibians or the node in mammals and inhibit epidermal fate in ectoderm, the ectodermal cells assume the neural default fate and turn into neuroectodermal cells. These cells further differentiate into the nervous system and also some non-neural cells via interaction with adjacent tissues. Failure in neural induction leads to failure of embryogenesis, and ectopic neural induction due to ectopic organizer or node activity or activation of embryonic neural genes causes a formation of secondary body axis or conjoined twins. A similar principle underlies tumorigenesis. Increasing evidence has demonstrated that the core property of cancer cells is neural stemness. Therefore, cancer cells are cells with the loss of original cell identity and gain of neural stemness, and consequently tumorigenicity and pluripotency, due to various intra-/extracellular insults in postnatal animals. Unlike that pluripotent cells (embryonic pluripotent cells, neural stem cells and cancer cells) can differentiate and integrate into embryonic development, cancer cells are capable of self-renewal and differentiation, but cannot integrate into normal tissues in a 2 postnatal animal, ultimately leading to tumor formation. Neural induction and the unique property of neural stemness provide an inclusive explanation for embryogenesis, conjoined twin formation and tumorigenesis. Based on these findings, I discuss about some confusion in cancer research, e.g., epithelial-mesenchymal transition, and propose to distinguish the causality and associations, and the causal and supporting factors involved in tumorigenesis, and suggest revisiting the focus of cancer research. Integration of evidence from developmental and cancer biology indicates that neural stemness determines tumorigenicity and pluripotency, and neural induction drives embryogenesis in gastrulating embryos but a similar process drives tumorigenesis in a postnatal animal.
The Antiatherogenic Effects of Flavonoid on Cholesterol Efflux Capacity
Authors: Ayoub Maha
Published: August 2022

One of the mechanisms used in the management and cure of atherosclerosis is reverse cholesterol transfer (RCT), which plays a vital role in the export of cholesterol from peripheral cells. Cholesterol efflux from macrophages in the subintima of the vessel wall is a critical part of RCT. ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) are involved in the transfer of cholesterol from arterial macrophages to extracellular high-density lipoprotein cholesterol (HDL). The HDL then transports esterified cholesterol to the liver for elimination. An important factor in the reverse cholesterol transport and excretion of extracellular cholesterol is HDL. Atherogenesis can be prevented by altering the processes of RCT and cholesterol efflux, and this might lead to novel treatment options for cardiovascular disease. Research of novel modifying variables for RCT and cholesterol efflux is necessary. A better understanding of RCT's molecular processes has been gained via research, allowing for the creation of new treatments that make use of RCT's potential for pharmacological improvement. The purpose of this review is to provoke discussion on the potential impact of selected flavonoids on cholesterol efflux on the progression of atherosclerosis (Fig. 1.).
Characterization and Comparison of CubeSat and Drone Platform Jitter Effects on Laser Beam Pointing Stability
Authors: Ishola Femi , Carrasco-Casado Alberto , Cordova Rodrigo , Masui Hirokazu , Munemasa Yasushi , Trinh Phuc V. , Fuse Tetsuharu , Tsuji Hiroyuki , Cho Mengu , Toyoshima Morio
Published: August 2022

Adaption of laser communication terminals to airborne and lean-satellite platforms is now a vogue, made possible due to the progressing advancements in lightweight components and compactness of onboard electro-optical transceivers and control systems. This enables highly secured and superior data-transmission rates beyond multiple Gigabit/second on CubeSats and drones compared to Megabit/second rates offered by similar radio-transceivers form factors. However, laser-transmission links require a very stringent beam-pointing stability because they are easily perturbed by attitude variations and micro-vibrations generated by the host platform’s propulsion system or other mechanically active subsystems in proximity with the transmitter’s optical head. Severe line-of-sight jitter causes the downlink laser beam to drift from the targeted receiving system’s field-of-view, inducing pointing errors, increasing signal outage probability and information loss. We experimentally examine the platform jitter generated by the propellers of an hexacopter drone during ground operation and the attitude-control unit’s reaction wheels in a 6U CubeSat structure. We determined the vibration spectrum unique to these platforms and accordingly prescribe requirements for applicable optical fine pointing and disturbance isolation or suppression systems needed to achieve a high-fidelity laser-communication link.
The new public management and implications on teaching work in the public sector
Authors: Raimann Ari , Oliveira Eulália Gonçalves Souza
Published: August 2022

The objective of this text is to analyze the State Reform and the implementation of the New Public Management (NPM) and its implications in the field of education, especially in the teaching work in the public sector. The restructuring of education from the 1990s onwards, in the context of the NPM, imposes on teaching work principles and values arising from the productive society of capital, with determinations from the private sector. The text stems from extensive research carried out at the Stricto Sensu Postgraduate level. Data were collected in a municipality in the state of Mato Grosso, in the municipal and state network.
Analisis Indeks Pencemaran Sungai Ampel Desa Sletreng Kabupaten Situbondo
Authors: Pahlewi Anita Diah
Published: August 2022

Sungai Ampel merupakan salah satu sungai yang berada di Desa Landangan, Kecamatan Kapongan Kabupaten Situbondo. Sungai ini digunakan masyarakat untuk mengairi persawahan, memancing, dan lain sebagainya. Adanya PT. Panca Mitra Multiperdana Tbk. yakni produsen hasil olahan udang disekitar sungai membawa dampak terhadap kualitas air sungai tersebut. Penelitian ini bertujuan untuk menganalisis kualitas air di sungai Ampel. Analisis dilakukan dengan menggunakan metode indeks pencemaran sungai berdasarkan Keputusan Menteri Lingkungan Hidup Republik Indonesia nomor 115 tahun 2003. Sungai Ampel sebagai daerah penelitian yang dialiri pipa pembuangan limbah hasil olahan udang serta dekat dengan pertambakan udang warga setempat. Pengambilan data dilakukan secara In situ dengan menggunakan botol kaca gelap ukuran 150 ml dan botol bening ukuran 600 ml, disimpan dalam coolbox. Lokasi penelitian dibagi dalam 3 lokasi titik sampling. Hasil penelitian menunjukkan bahwa analisis menggunakan indeks pencemaran di Sungai Ampel yakni pada Stasiun I sebesar 2,59, stasiun II sebesar 4,29, serta stasiun III sebesar 4,52 dimana ketiganya dikategorikan sebagai tercemar ringan.
Analisis Prediksi Motion Sickness Incidence (MSI) Pada Kapal Penyeberangan Di Perairan Makassar
Authors: Bawias Ishak , Lungari Fitria , Risal Risal
Published: August 2022

Motion sickness pada kapal dikenal juga dengan istilah mabuk laut, mabuk laut adalah gejala sakit yang diakibatkan karena gerakan kapal yang mengakibatkan gejala fisik yang tidak nyaman yang ditandai dengan susah bernafas, pusing, mual ,pucat dan muntah. Penyebab utama mabuk laut adalah tidak adanya kesamaan rangsang atau conformity antara stimulus, mata dan labirin telinga yang diterima oleh otak manusia. Arah datang gelombang sangat berpengaruh terhadap stabil atau tidaknya kapal yang ditumpangi. Metode penelitian menggunakan simulasi software motion kapal.  Hasil penelitian menyimpulkan bahwa, kondisi kapal stabil ditunjukkan oleh gelombang yang datang dari arah 0 atau kondisi kapal berlayar searah dengan gelombang yang datang. Sehingga, diprediksikan tidak ada penumpang yang mengalami mabuk perjalanan. Sedangkan kondisi kapal tidak stabil ditunjukkan oleh kapal dengan arah gelombang 180 atau kondisi kapal berlayar berlawanan dengan arah datangnya gelombang. Sehingga diprediksikan penumpang akan mengalami mabuk laut setelah 2 jam perjalanan.
Analisis Ship Resistance Untuk Menentukan Daya Main Engine Kapal
Authors: Ali Sulaiman , Ramadani Fitria , Ali Syurkarni , Syahputra Delly
Published: August 2022

Perhitungan tahanan kapal dapat dilakukan dengan menggunakan perhitungan matematis. Untuk menentukan daya mesin utama kapal dibutuhkan nilai tahanan kapal yang terbentuk dari bentuk lambung kapal sendiri. Penelilitian ini di desain untuk mendapatkan sebuah model dengan menggunakan software naval architecture. Dari model kapal cargo tersebut selanjutnya akan dihitung sehingga menghasilkan nilai tahananan dan power kapal yang dibutuhkan. Metode yang digunakan dalam perhitungan tersebut menggunakan Metode Compton. Pada kecepatan maksimal kapal cargo yaitu 12.5 knot, menghasilkan nilai tahanan sebesar 309.8 Kn dengan power sebesar 2671.370 Hp
Pengaruh Performa Turbocharger Terhadap Kinerja Mesin Induk Di MT. Green Park
Authors: Marsudi Sugeng
Published: August 2022

Mesin Penggerak Utama (MPU) atau Mesin Induk di atas kapal merupakan sebuah mesin yang berfungsi untuk menggerakkan kapal maju dan mundur. MPU memiliki dua sistem pemasukan udara pembakaran ke dalam silinder yaitu sistem pemasukan hisap yang mengandalkan kevakuman ruang bakar akibat gerakan piston atau  dengan sistem pemasukan tekan yaitu dengan melengkapi mesin dengan Turbocharger. Tujuan utam Turbocharger, menaikkan tekanan udara pembakaran dengan cara mengkompresi udara tersebut sehingga massa aliran udara masuk ruang pembakaran menjadi lebih tinggi dibandingkan udara atmosfir. Jika massa aliran udara pembakaran menurun yang disebabkan oleh berbagai kondisi, maka akan berpengaruh pada proses pembakaran yang tidak sempurna yang secara visual bisa ditandai dengan asap yang berwarna lebih hitam. Pembakaran yang tidak sempurna akan mempengaruhi daya dan kinerja mesin diesel tersebut.
MAKNA DAKWAH TEOLOGIS DALAM FILM SICCIN 1: PENDEKATAN SEMIOTIKA ROLAND BARTHES
Authors: Kurniasari  , Iswahyudi
Published: August 2022

Film dianggap media yang paling ampuh terhadap massa sebab sifatnya yang audio dan visual. Film menjadi sangat efektif sebagai media untuk menyebarkan luaskan dakwah Islam. Dengan film, pesan-pesan dan makna pesan yang disampaikan lebih ringan dan tidak terkesan menggurui. Terlebih dalam hal pemahaman terkait agama. Sampai sekarang pembahasan tentang tauhid atau teologi Islam masih merupakan tema yang selalu menarik untuk diteliti. Hidup manusia di dunia ini sangat erat kaitannya dengan Allah sang pencipta alam semesta. Dengan adanya bahasan tentang teologi Islam maka diharapkan dapat memupuk rasa cinta kepada Allah yang lebih mendalam. Penelitian ini merupakan penelitian kualitatif dengan paradigma analisis untuk mengungkap adanya makna dakwah teologis dalam film tersebut. Teknik pengumpulan data dilakukan dengan menggunakan analisis dokumen. Sedangkan Teknik analisis data menggunakan analisis semiotika Roland Barthes. Hasil dari penelitian ini adalah: Pertama, Makna denotasi dakwah teologis dalam film Siccin 1: dalam bentuk tanda orang berdoa, berdzikir, penanaman keimanan kepada Allah dan yang terakhir, kepercayaan adanya surga dan neraka. Kedua, Makna konotasi dakwah teologis dalam film Siccin 1 yaitu berupa doa yang ditujukan kepada Allah dan kepada selain Allah, yakni Jin. Ketiga, Makna Mitos dakwah teologis dalam film ini adalah, bahwa doa tidak selamanya merepresentasikan hal-hal yang baik, bisa juga merepresentasikan hal-hal yang tidak baik. Kemudian mengenai penciptaan dan keberadaan makhluk ghaib, yakni jin atau setan yang hidup berdampingan dengan manusia adalah benar adanya dan kita patut untuk mempercayai keberadaannya. Serta adanya balasan untuk orang yang beriman dan kufur, berupa balasan di akhirat yakni surga atau neraka.
Association of lower back pain(LBP) and knee osteoarthritis(KOA); a systematic review
Authors: Amarasinge Piyumi Lakmali , Wadugodapitiya Surangika , Weerasekara Ishanka
Published: August 2022

Background: Osteoarthritis and lower back pain (LBP) are among most common health problems worldwide leading pain and disability. The purpose of this study was to systematically review the evidence to find any association between knee osteoarthritis (KOA) and LBP.Methods: The databases of Scopus, Medline and EMBASE were searched from inception to 22.02.2021. Any study published in English assessing live humans over 18 years with KOA and LBP were eligible to be included. Data were independently assessed by two researchers. Data were extracted based on the participants, outcomes related to knee, outcomes related to lumbar spine, association between LBP and KOA and study design approach. Results: Of 8620 titles and abstracts, duplicates were removed and 6219 were screened. Altogether 87 full texts were screened and 12 were eligible for the final inclusion.Conclusions: There were some biomechanical and clinical associations observed between LBP and KOA. High pelvic incidence is a risk factor for development of spondylolisthesis and KOA. Development and progression of KOA in patients with degenerative spondylolisthesis may be induced by significantly greater mismatches of lumbo-pelvic sagittal alignment. Elderly patients with degenerative lumbar spondylolisthesis and comorbid severe KOA reported a different pelvic morphology, increased sagittal malalignment with a lack of lumbar lordosis due to double-level listhesis, and greater knee flexion contracture than in patients with no to mild and moderate KOA. Knee pain intensity was higher in KOA when presents with LBP. People with concurrent LBP and KOA have reported poor function with more disability. Assessing both back and knee joints should be considered when treating KOA and vice-versa, to clinically manage, and to prevent further progression. High quality RCTs with a long-term follow-up should be designed to assess the exercise programs consist of both lumbar and knee exercises for these patients. Systematic review registration: PROSPERO (CRD42022238571)
Those who speak survive: The value of the verbal component of GCS in trauma
Authors: Cevik Arif , Alao David , Alyafei Eman , Abu-Zidan Fikri
Published: August 2022

Aim: To evaluate the predictive value of the individual components of GCS in predicting the survival of trauma patients on arrival in the emergency department. Methods: This is a post-hoc analysis of previously published data on trauma patients in Al Ain City. We obtained data on patients that presented with trauma to Al-Ain Hospital who were admitted for more than 24 hours or died at the Emergency Department or hospital from January 2014 to December 2017. Studied variables included demographics, vital signs, Glasgow Coma Scale (GCS), GCS components, Injury Severity Score (ISS), and in-hospital mortality. We entered factors found to have a p value of <0.1 in univariate analysis into a direct logistic regression model to define factors that predict survival.Results: There were 3519 trauma patients in the registry. The median (range) of age, respiratory rate, and ISS were significantly lower in patients who survived 31(0-105) versus 37 (1-76) years, p = 0.031; 18 (6-56) versus 22 (0-35) breaths per minutes, p = 0.019, and 4 (1-75) versus 16.5 (1-75), p < 0.001, respectively). Systolic blood pressure and GCS were significantly higher in patients who survived (median (range) 133 mmHg (21-265) versus 117mmHg (0-209), p = 0.003, and 15 (3-15) versus 6 (3-15), p < 0.001, respectively). Logistic regression analysis revealed that ISS and GCS-Verbal Response (GCS-VR) were significant predictors of survival. GCS-VR was the most significant predictor for survival, with Area Under the Curve of 0.89, p < 0.001.Conclusion: In general trauma patients, acute trauma care professionals can use GCS-VR to predict survival instead of the total GCS score or ISS.
Development of lacrimal gland organoids from iPSC derived multizonal ocular cells
Authors: Asal Melis , Koçak Gamze , Sarı Vedat , Reçber Tuba , Nemutlu Emirhan , Utine Canan Aslı , Guven Sinan
Published: August 2022

Background
Lacrimal gland plays a vital role in maintaining the health and function of the ocular surface. Dysfunction of the gland leads to disruption of ocular surface homeostasis and can lead to severe outcomes. Approaches evolving through regenerative medicine have recently gained importance to restore the function of the gland. The aim of this study is to use tissue engineering strategy to develop a functional lacrimal gland from human induced pluripotent stem cells (iPSCs).
Methods
Using human iPSCs, we generated functional in vitro lacrimal gland organoids by adopting the multi zonal ocular differentiation approach. We differentiated human iPSCs and confirmed commitment to neuro ectodermal lineage, following ocular differentiation. Gene expression and protein levels were measured at several time points up to 45 days for differentiation.
Results
We identified emergence of mesenchymal and epithelial lacrimal gland progenitor cells by the third week of differentiation. Differentiated progenitors underwent branching morphogenesis in the following weeks, typical of lacrimal gland development. We were able to confirm the presence of lacrimal gland specific acinar, ductal, and myoepithelial cells and structures during weeks 4–7. Further on, we demonstrated the role of miR-205 in regulation of the lacrimal gland organoid development by monitoring miR-205 and FGF10 mRNA levels throughout the differentiation process. In addition, we assessed the functionality of the organoids using the β-Hexosaminidase assay, confirming the secretory function of lacrimal organoids. Finally, metabolomics analysis revealed a shift from amino acid metabolism to lipid metabolism in differentiated organoids.
Conclusions
These functional, tear proteins secreting human lacrimal gland organoids harbor a great potential for the improvement of existing treatment options of lacrimal gland dysfunction and can serve as a platform to study human lacrimal gland development and morphogenesis.
Characterization of an Italian landrace of Cyclanthera pedata (L.) Schrad. of herbal and horticultural interest
Authors: Zuccolo Marco , Pedrali Davide , Leoni Valeria , Borgonovo Gigliola , Bassoli Angela , Giorgi Annamaria , Giupponi Luca
Published: August 2022

Caigua (Cyclanthera pedata (L.) Schrad.) is a native species of the Andes whose fruits are recently gaining attention as herbal and healthy product. A genotype of Caigua traditionally cultivated in Camonica Valley (Italian Alps), called “Ciuenlai” (or “Milione/Milioncino”), is almost unknown. For this reason, the phytochemical, nutritional and ecological (functional strategy) characterization of “Ciuenlai” was carried out. Phytochemical and nutritional analyses were performed considering its fruits, leaves, sprouts, and seeds, and compared with commercial South American plant material. Fruits of “Ciuenlai” showed a similar content of phenolic compounds but a lower content of saponins and flavanones and dihydroflavonols than the comparison samples. Conversely, the content in caffeoylquinic acid (frequently considered a quality marker for herbal use) was four times higher for “Ciuenlai” (0.64 ± 0.04%) comparing with the commercial genotype grown in the same area (0.15 ± 0.01%). Interestingly, leaves and sprouts of “Ciuenlai” resulted rich in secondary metabolites, including saponins and flavanones and dihydroflavonols, suggesting that these parts could be eligible for herbal use. Considering the ecological and agronomical features, “Ciuenlai” showed a more ruderal strategy, and different growth, producing more fruit earlier in the season, much smaller than the South American genotype. “Ciuenlai” could have developed an ecological adaptation to the peculiar climatic conditions of the mountain areas of Camonica Valley, different from the native area. The herbal use of “Ciuenlai” could be a useful strategy for its valorisation, other than the promotion of this product as typical food.
Parallel MS-Kmeans clustering algorithm based on MapReduce
Authors: Li Guodong , Wang Chunhong , Li Kai
Published: August 2022

Aimed at the problems of initial points selection, outliers influence and cluster instability of traditional K-means algorithm in big data clustering, an MS-Kmeans algorithm based on MapReduce framework was proposed. The algorithm selected multiple non-outlier points as the candidate center points, and mean shifted the candidate center points, used the maximum-minimum principle to select K initial center points from the candidate center points, and then executed the K-means algorithm to find the final center points. In order to improve the running speed of the algorithm for clustering large data sets, the algorithm used MapReduce framework to implement parallel computing on Hadoop platform. The experimental results showed that the parallel MS-Kmeans algorithm is feasible in big data clustering, and the algorithm performs well in terms of performance, speed and stability
Changes in pelvic tilt related to body position measured with Smart Navigated Ultrasound mobile system
Authors: Kochman Andrzej , Morawska-Kochman Monika , Kozak Jozef , Daniol Mateusz , Sibiński Marcin
Published: August 2022

The aim of the study was to assess the changes of pelvic tilt between standing and supine position with the Smart Navigated Ultrasound (SNU) mobile system. In this prospective study, the pelvic tilt in the standing and supine pelvis was recorded in 16 orthopedically healthy female volunteers, mean age 37.5 years. All measurements were performed with SNU mobile system, consisting of a smartphone-based optical tracking device, medical-grade tablet, an ultrasound device with a transducer, and two rigid body optical markers. Anterior pelvic tilt was noted in all but two patients in the standing position and in all but one in the supine position. For 13 subjects, the pelvis rotated posteriorly during movement from the supine to standing position, in three cases, the change was in the opposite direction. Mean anterior pelvic tilt significantly reduced from lying down (-9.8) to (-4.9) standing (p = 0.04). The study showed that pelvic tilt is different in supine and standing position and is changing from anterior to more posterior, respectively in most cases. The SNU navigation system may be a useful to prevent complications related to cup position due to differences in pelvic tilt between those positions and could be used for large-scale screening purposes.
Dorzagliatin improves glucose-stimulated GLP-1 secretion in T2D and is synergistic with sitagliptin in glycemic control
Authors: Chen Li , Zhang Jiayi , Sun Yu , Zhao Yu , Liu Xiang , Fang Zhiyin , Feng Lingge , He Bin , Zou Quanfei , Tracey Gregory
Published: August 2022

To evaluate the clinical pharmacokinetics and pharmacodynamics of dorzagliatin in glycemic control and glucose sensitivity alone or in combination with sitagliptin in obese T2D subjects. Fifteen obese T2D subjects were treated with sitagliptin 100 mg QD followed by a combination of sitagliptin 100 mg QD with dorzagliatin 75 mg BID at second stage and the third stage of dorzagliatin 75 mg BID alone. Together with improvement in early-phase insulin secretion, an additional 30% glucose-lowering effect was observed in combination (dorzagliatin + sitagliptin) in glucose iAUC0 − 4h. A significant increase of iCmax of glucose-stimulated GLP-1 secretion (GLP-1total) was observed in dorzagliatin monotherapy. The pharmacokinetic GMRs (AUC0 − 24h and Cmax) of dorzagliatin and sitagliptin for combination/either monotherapy fell within 80% -125%. Dorzagliatin regulates glucose-stimulated GLP-1 release and synergizes with sitagliptin in optimizing glycemic control in obese T2D patients. Lack of clinically meaningful pharmacokinetic interactions between dorzagliatin and sitagliptin supports their oral co-administration for diabetes management.
Specialized neuronal modules for economic and single-attribute choice in the orbitofrontal cortex
Authors: Cai Xinying , Xu Chengze , Ni Kuntan
Published: August 2022

An important aspect of biological intelligence is the ability of quick task switching. Such ability may be realized through a neural system equipped with functionally specialized modules subserving each task. The orbitofrontal cortex (OFC) harbors a persistent circuit supporting economic decisions under different contexts. To examine the specialization of this circuit, we contrasted the coding of the same neurons in the OFC of rhesus monkeys under economic choice (EC) and single-attribute choice (SC). In EC, OFC neurons largely encoded offer value, chosen value and choice outcome in goods space. Strikingly, these neurons were tuned out in SC while a complementary set of neurons encoded SC-related variables in a spatial reference frame. Moreover, in EC, neurons encoding the same value-related variable are anatomically clustered and the noise correlation among these neurons dropped significantly when the animal switched from EC to SC, suggesting altered functional organization. Thus, specialized modules in the OFC may support cognitive flexibility in choice.
Net-zero CO2 emissions scenarios for Switzerland
Authors: Panos Evangelos , Kannan Ramachandran , Hirschberg Stefan , Kober Tom
Published: August 2022

Switzerland has one of the lowest CO2 intensities among industrialised countries. The transition to net-zero emissions is further complicated by limited domestic mitigation options, which tend to have high costs, raise energy security concerns, and trigger socio-economic barriers in policy implementation. Research on these issues is also relevant to the societal and political debates on country energy transitions worldwide. We apply robust techno-economic energy systems modelling to highlight the challenges of the Swiss energy transition under different technical, socio-economic, and geopolitical contexts and suggest feasible technical solutions based on low-carbon technologies, efficiency, and flexibility. Import independency and net-zero emissions by 2050 require an additional cumulative discounted investment of 300 BCHF2019 in energy efficiency, domestic renewable and hydrogen technologies. The average per capita costs of net-zero emissions are 320–1390 CHF2019/yr., depending on domestic mitigation options exploitation, integration of Switzerland in international energy markets, energy security and resilience ambition.
An investigation of the shearing performance and sheared surface characterization of Ultra-Strength DP Steel-Al Explosive Welded Plate Composite
Authors: DEMİR Bilge , Ali Khalil Belras , Gürün Hakan , Acarer Mustafa
Published: August 2022

Piercing/blanking-cutting sheet metals with a punch are still the industry's most preferred process. This study previously aimed to fabricate the Ultra Strength DP1200 Steel-AA1100 sheet composite and then research punch shearing performance and surface characterization of this plate composite and original materials. Experimental studies include various applications such as metallography and micro image analysis, explosive welding of DP1200-Al dissimilar materials, punching operations, and tensile testing. Five different shaped punches were used in the Punching process. The force graphs corresponding to the procedure times were obtained thanks to the load-cell computer system. The resulted surface qualities of the cutting edges of the punched samples were evaluated by image analysis using digital and SEM microscopy. Shear analyzes were also performed using Finite element analysis to ensure consistency with experimental studies. As a result, the composite plate of DP1200 steel − 1100 aluminium sheet metals has been fabricated successfully by an explosive welding technic. Besides, the punching results showed good agreement between modelling and experimental punching forces. The highest cutting forces were observed when the punch "0" (flat-punch, 0°). The lowest cutting forces were obtained from the other used punch forms using punch R2, V16, R1, and 16, respectively. Moreover, the punched surfaces have been observed by comparing the force-time graphs. In addition, this study is a pioneer in the literature on its concepts, such as explosive weld materials and their punch process.
Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy
Authors: Yoshioka Wakako , Iida Aritoshi , Kyuto Sonehara , Yamamoto Kazuki , Oya Yasushi , Mori-Yoshimura Madoka , Kurashige Takashi , Okubo Mariko , Ogawa Megumu , Matsuda Fumihiko , Higasa Koichiro , Hayashi Shinichiro , Nakamura Harumasa , Sekijima Masakazu , Okada Yukinori , Noguchi Satoru , Nishino Ichizo
Published: August 2022

Background GNE myopathy is an autosomal recessive distal myopathy caused by biallelic variants in GNE, which encodes a protein involved in sialic acid biosynthesis. Compound heterozygosity of the second most frequent variant among Japanese patients with GNE myopathy, GNE c.620A>T, occurs in the expected number of patients; however, homozygotes for this variant are rare. The aim of this study was to elucidate the pathomechanism caused by c.620A>T.Methods Genome sequencing, identity-by-descent mapping, and RNA-seq analyses were conducted for GNE c.620A>T homozygotes. Blood and muscle sialylation levels were measured, and three-dimensional structural modeling of GNE oligomers was conducted using Alphafold2.Results The estimated frequency of the c.620A>T variant in the Japanese general population is 0.00161, equating to 238 homozygotes in total, but only three homozygotes with GNE myopathy have been identified. Identity-by-descent mapping indicated two distinct c.620A>T haplotypes, which were not correlated with patient clinical characteristics. Patients homozygous for c.620A>T had mildly decreased sialylation, and no additional pathogenic variants in GNE or abnormalities in transcript structure or expression of other genes related to sialic acid biosynthesis in skeletal muscle. Structural modeling of full-length GNE dimers revealed that the variant amino acid localized close to the monomer interface, but far from catalytic sites, suggesting functions in enzymatic product transfer between the epimerase and kinase domains on GNE oligomerization.Conclusion Homozygotes for c.620A>T rarely develop myopathy, while symptoms occur in compound heterozygotes, likely because of mildly decreased sialylation, due to partial defects in oligomerization and product trafficking by the mutated GNE protein.
Rational construction of Co-promoted 1T-MoS2 nanoflowers towards high-efficiency 4-nitrophenol reduction
Authors: Zhang Cen , Wang Li , Huang Xi , Bai Liang , Yu Qiyuan , Jiang Bin , Zheng Chenlu , Cao Jing
Published: August 2022

Developing efficient and cost-effective non-noble metal catalysts for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) is of great importance. Herein, Co-promoted 1T-MoS2 nanoflowers were synthesized via a one-step hydrothermal method. The influence of Co content on the structure and catalytic performance of 1T-MoS2 was studied in detail. It was found the highest activity could be achieved due to the synergy effect of Co-Mo-S and CoS2 active phase. The reaction rate constant was as high as 0.908 min-1, and the catalyst exhibited excellent stability after recycling five times. We believe the understanding of the role of Co promoter would provide new insights for the rational design of highly efficient MoS2-based catalysts towards 4-NP reduction in wastewater.
Non-functional complications associated with radical hysterectomy
Authors: Alonso-Espías María , Alonso-García Marcos , García-Pineda Virginia , Gracia Myriam , Siegrist Jaime , Diestro María Dolores , Hernández Alicia , Zapardiel Ignacio
Published: August 2022

Purpose: Bladder dysfunction is the most frequent complication after radical hysterectomy. However, there are other relevant complications associated with cervical cancer surgery much less reported in literature. The aim of this study was to evaluate the frequency of non-functional complications associated with radical hysterectomy and to determine if there is any risk factor associated with their appearance. Methods: A retrospective study was conducted, including consecutive patients diagnosed with early-stage cervical cancer who underwent radical hysterectomy at La Paz University Hospital from January 2005 to December 2019. Data from intraoperative, short-term, and long-term complications were collected. A multivariate analysis was performed in order to identify potential predictors of surgical complications. Results: A total of 111 patients were included. Intraoperative complications occurred in 13(11.7%) women. Multivariate analysis showed a greater risk of intraoperative complications if microscopic parametrial involvement was present (OR=16.7; 95%CI 1.4-195). 41(36.9%) patients had any short-term postoperative complication, being urological the most frequent ones. Lymphedema was the most frequent long-term complication and occurred in 20(18%) patients. In short-term and long-term univariate analysis, TNM histological tumor stage was tended to be associated (p=0.07) to short-term postoperative complications, and FIGO stage was significatively associated (p=0.05) to long-term postoperative complications. Conclusion: Urological complications are the most frequent ones after radical hysterectomy. However, other less frequent complications such as genitourinary fistula or lymphedema are also important due to their impact on the quality of life of patients. We found that parametrial involvement in the postoperative pathological analysis was associated with higher intraoperative complications rate.
Nitrogen-doped graphene sheets as efficient nanofillers at ultra-low content for reinforcing mechanical and wear-resistant properties of acrylic polyurethane coatings
Authors: Xu Hui , Liu Danlian , Liang Lizhe , Tian Zhi Qun , Shen Pei Kang
Published: August 2022

The enhancement to the mechanical and wear-resistant properties of polymer coatings plays a vital role for their application in hostile serving environment and nanofiller is effective for this destination. Herein, we systematically investigate a new nanofiller, nitrogen-doped graphene sheets (NGS), which possess a multilayer sheet-like morphology and share a good compatibility with water. After the incorporation of NGS into a two-component waterborne polyurethane (WPU), the mechanical and wear-resistant properties of NGS/WPU composite coatings significantly improve and wear resistance behaves best at an ultra-low content, reaching up to 0.05 wt‰. Wherein, Young’s modulus is elevated by 52.67% and tensile strength is appreciably boosted by 58.87%. Simultaneously, apparent reduction of weight loss of 78.74% is observed in the abrasion testing, and the ductility of NGS/WPU composite films is reduced by 48.38%. These make it possible that an ultra-low content of nanofiller efficiently reinforces polymer-based composites to achieve a trade-off between mechanical properties. Moreover, the wear-resistance mechanism is investigated, and the interaction between NGS and WPU segments is explored to find the reason that the mechanical and wear-resistant properties of NGS/WPU composite coatings are improved at an ultra-low content.