bluuebunny/crossref_metadata_2025 huggingface dataset:
Revolutionary Analysis of the Pointwise Stationary Fluid Flow Approximation model of the non-stationary queue with Pointwise Stationary Fluid Flow Approximation applications to the Internet of Things
Authors: A Mageed Dr Ismail
Published: February 2024

This paper provides the first-time ever analytic modelling for Pointwise Stationary Fluid Flow Approximation(PSFFA) model of the non-stationary
Cardiomyocyte Heat Production Measured In Vitro with Temperature Probes and by Means of Differential Isothermal Calorimetry Indicates a Role of the ABA/LANCL1-2 Hormone/Receptors System in Thermogenesis
Authors: Zocchi Giovanni , Fontanelli Flavio , Spinelli Sonia , Sturla Laura , Passalacqua Mario , Urra José Cristobal Gonzalez , Delsante Simona , Zocchi Elena
Published: February 2024

Abscisic acid (ABA) is a conserved “stress hormone” in unicellular organisms, plants and animals. In mammals, ABA and its receptors LANCL1 and LANCL2 stimulate insulin-independent cell glucose uptake and oxidative metabolism: overexpression of LANCL1/2 increases, and their si-lencing conversely reduces, mitochondrial number, respiration and proton gradient dissipation in muscle cells and in brown adipocytes. We hypothesized that the ABA/LANCL hor-mone/receptors system could be involved in thermogenesis.
Heat production by LANCL1/2-overexpressing vs. double-silenced cells was compared in rat H9c2 cardiomyocytes with two different methods: differential temperature measurements using sensitive thermistor probes, and differential isothermal calorimetry.
Results indicate that overexpressing cells generate an approx. double amount of thermal power compared with double-silenced cells, and that addition of ABA further doubles heat production in overexpressing cells. With the temperature probes, we find a time-scale of approx. 4 min for thermogenesis to “turn on” after nutrient addition.
These results identify the ABA/LANCL hormone receptors system as a hitherto unknown regu-lator of cell thermogenesis. Pharmacologic means of increasing metabolic energy dissipation are considered a promising strategy to reduce oxidative stress and lipid accumulation at a cellular and organismic level: from this study, LANCL1-2 proteins emerge as targetable controllers of ther-mogenesis through their natural ligand ABA.
Mangroves as Coastal Protection for Restoring Low-Energy Waterfront Property
Authors: Weaver Robert J. , Stehno Abigail L.
Published: February 2024

Mangroves offer vital ecological advantages including air and water filtration, coastal and estuarine habitat provision, sediment stabilization, and wave energy absorption. Their intricate root systems play a key role in safeguarding shorelines from tsunamis and erosive storms by dissipating wave energy. Moreover, mangroves shield against boat wakes and wind-waves, bolstering shoreline defense. Wave dissipation is a function of forest width, tree diameter, and forest density. Restoration efforts of juvenile mangroves in Florida’s Indian River Lagoon (IRL) aim to reduce wave energy in areas vulnerable to erosion. Physical model testing of wave dissipation through mangroves is limited due to the complexity in representing the mangrove structure, where prop roots are non-uniform in both diameter and location. Previous studies have quantified wave dissipating effects through use of scaled and parameterized mangrove structures. This study measures the dissipation effects of live mangroves in a wave flume, forced by conditions representative of the IRL. These measurements are used to validate a parameterized dowel model. Error between wave attenuation factors for the live mangrove and dowel system was on average 2.5%. Validation of the modularized dowel system allowed for further parameterized testing to understand forest structure effects, such as sediment stabilization and wave attenuation.
Characteristics of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in the Dog Population
Authors: Czekaj Zuzanna , Klimowicz-Bodys Malgorzata Dorota , Karwanska Magdalena , Siedlecka Magdalena , Rypula Krzysztof
Published: February 2024

Background: The bacterium Capnocytophaga spp. is a part of the oral microbiome of dogs, which has zoonotic potential. This study aimed to assess factors that influence the prevalence of Capnocytophaga cynodegmi and Capnocytophaga canimorsus in Wrocaw’s dog population. Methods: Molecular detection (PCR) involved 105 swabs, examining parameters such as oral cavity condition, underlying health issues, recent antibiotics, age, medications, material collection, and dog chews. Results: The study highlighted significant associations between the presence of Capnocytophaga cynodegmi and oral cavity condition, material collection method, and use of dog’s chews. Conclusions: Correlations obtained in this study between the oral health of Wroclaw's dog population and the presence of Capnocytophaga cynodegmi suggest its significance in the oral microbiome of dogs. Limitations, including the small sample size, highlight the need for more research to comprehensively understand additional factors that affect the prevalence of Capnocytophaga spp. in dogs
Evaluation of the Effect of Particle Size and Biomass-to-Water Ratio on the Hydrothermal Carbonization of Sugarcane Bagasse
Authors: Moreno-Chocontá Leidy Natalia , Lozano-Pérez Alejandra Sophia , Guerrero-Fajardo Carlos Alberto
Published: February 2024

The generation of platform chemicals and hydrochar is of great interest because they reduce dependence on fossil resources and contribute to climate change mitigation by reducing carbon emissions. The main objective of this study was to evaluate the effect of biomass particle size and biomass water ratio in a hydrothermal conversion system for the generation of value-added products obtained from sugarcane bagasse. Biomass characterization was performed using proximal, elemental, and structural analysis; hydrothermal carbonization was carried out at 220 to 260 °C for one hour; and conversion was monitored using pH, conductivity, and IR spectroscopy. Platform chemicals were quantified by HPLC-IR. Hydrochars were characterized by scanning electron microscopy and energy dispersive spectroscopy. The results show that with a biomass:water ratio of 1:50 and a particle size of 212 μm at 220 °C, a yield of 31.07 % of platform chemicals was obtained on a dry basis. Likewise, the hydrochar with the highest carbon content and a higher porosity appearance was obtained with a biomass-to-water ratio of 1:50 and a particle size of 600 μm at 260 °C.
Digital Battle: A Three-Layer Distributed Simulation Architecture for Heterogeneous Robot System Collaboration
Authors: Gao Jialong , Liu Quan , Chen Hao , Deng Hanqiang , Zhang Lun , Sun Lei , Huang Jian
Published: February 2024

This paper proposed a three-layer distributed simulation network architecture: 1. Distributed virtual simulation network, 2. Perception and control sub-network, and 3. Collaborative communication service network. This simulation architecture runs on a distributed platform. The platform can provide a unique virtual scenario and several simulation services to verify the individual robot system's basic perception, control, and planning algorithms and the distributed collaborative algorithms of heterogeneous multi-robot systems. Furthermore, we designed a simulation experiment scenario for classical heterogeneous robot systems such as unmanned aerial vehicles (UAVs) and unmanned ground vehicles (UGVs). At last, We gave a rough estimation model of the bandwidth.
Dissimilarity among Species and Higher Taxa of Amphibians in a Hotspot of Biodiversity and Endemism in the Neotropics
Authors: Patrón Jaime Manuel Calderón , Joya Karen Peña , López Jorge Téllez , Gómez Eréndira Canales
Published: February 2024

The Mexican Republic ranks fifth in the world in terms of amphibian diversity, and within Mexico, the state of Oaxaca has the greatest amphibian richness and endemism. Unfortunately, various factors, such as land use change and global warming, have caused a global crisis that threatens the conservation of this class. In the state of Oaxaca, few studies of amphibians have been carried out at the state level. Several research has shown that an analysis of beta diversity provides information that can be applied to conservation strategies. In this work, we analyzed the beta diversity at the species level and higher taxon level for the amphibians of Oaxaca and their replacement components and the differences in richness for anurans and caudates separately between physiographic subprovinces. Very high beta diversity was recorded, with higher diversity occurring among caudates than among anurans. Replacement was the component that most contributed to this result, and the subprovinces with substantial environmental differences had the most dissimilar amphibian communities. The results of this study show the need to implement conservation strategies in subprovinces with high amphibian richness and endemism levels, following the example of Sierra Madre de Oaxaca (SMO)
Determinants of Dogs’ Helminth Treatment-Seeking Behavior among Dog Owners in Rural Northern Tanzania: Towards Control of Taenia multiceps, an Emerging Threat to Small Ruminants’ Productivity
Authors: Kibona Tito , Buza Joram , Shirima Gabriel
Published: February 2024

Taeniid infections pose a significant threat to both animal and public health, as certain tapeworms within this group can also infect humans, potentially leading to severe health conditions. Therefore, this calls for preventive and control measures, such as regular deworming of dogs. While the efficacy of deworming has been established in developed countries, there is a paucity of reported deworming practices in rural areas of developing countries, such as Tanzania. This study aims to understand determinants for helminth treatment-seeking behavior towards control of cestodial taeniid infections in rural settings in northern Tanzania. A cross-sectional study was undertaken in agropastoral and pastoral areas of northern Tanzania. Comprehensive data from household surveys in selected sub-villages were collected to ascertain dog ownership, dog deworming practices, and the availability of dewormers. Analytical methods were employed to discern how various determinants influenced deworming practices among dog owners in these communities. Awareness of dewormers specifically formulated for dogs emerged as a pivotal factor affecting dog deworming practices. Dog owners who were informed about appropriate dog dewormers were nearly two times more likely to engage in deworming compared to those with limited knowledge (OR = 1.78, 95% CI 1.77 - 4.18, p < 0.001). A majority 32(51.6%, 95% CI: 38.7-64.3) acknowledged accessing dewormers for livestock within their wards. Praziquantel a potent dewormer on cestodes was least known to most dog owners 2(13%, 95% CI: 2.3-41.6). Praziquantel, a potent and common dewormer effective against cestodial taeniid infections, remains relatively unknown in rural areas of northern Tanzania. Therefore, more awareness on appropriate deworming agents against taeniids in dogs should be raised in rural dog-keeping communities.
Division by Zero: Using Semi-structured Complex Numbers to Find the Inverse of a Singular Matrix and Show Its Applications
Authors: Jean Paul Peter , Wahid Shanaz
Published: February 2024

Matrices and their inverses allow accurate calculations to be produced quickly and compactly and can be used to control any process represented by a system of equations. Singular matrices require extensive workarounds (costing time and money) to solve these systems of equations because they have no inverse. Finding their inverse involves division by zero. Nevertheless, recently a new number set called semi-structured complex numbers was developed to enable division by zero in algebraic equations. The aim of this research was to demonstrate that the inverse of a singular matrix can be found using semi-structured complex numbers. This research reveals (1) Singular matrices and their inverses can be used to find a unique solution to a pair of simultaneous equations that appear to have infinitely many solutions or appear to have no solution; (2) Singular matrices map coordinates in projective space to coordinates in Euclidean space and their inverse maps coordinates in Euclidean space to coordinates in projective space; (3) the inverse of a singular matrix proves that parallel lines in Euclidean space do not intersect but in projective space intersect at a “point at infinity” and (4) collinear lines that intersect at infinitely many points in Euclidean space only intersect at one point in projective space.
High HER2 intratumoral heterogeneity is a predictive factor for poor prognosis in Early-stage and Locally Advanced HER2-positive Breast Cancer
Authors: Tanei Tomonori , Seno Shigeto , Sota Yoshiaki , Abe Kaori , Masunaga Nanae , Tsukabe Masami , Yoshinami Tetsuhiro , Miyake Tomohiro , Shimoda Masafumi , Matsuda Hideo , Shimazu Kenzo
Published: February 2024

PURPOSE: Breast cancer tumors frequently have intratumor heterogeneity. Tumors with high intratumor heterogeneity have caused therapeutic resistance and have human epidermal growth factor receptor 2 (HER2) heterogeneity in response to HER2-targeted therapies. This study aimed to investigate whether high HER2 heterogeneity levels were clinically related to poor prognosis for HER2-targeted adjuvant therapies resistance in primary breast cancers.
METHODS: This study included patients with primary breast cancer (n = 251) treated with adjuvant HER2-targeted therapies. HER2 heterogeneity was manifested by the shape of HER2 fluorescence in situ hybridization amplification (FISH) distributed histograms with HER2 gene copy number within a tumor sample. Those heterogeneity classified each tumor into the biphasic grade graph (high heterogeneity [HH]) group and the monophasic grade graph (low heterogeneity [LH]) group. Both groups were evaluated for disease-free survival (DFS) and overall survival (OS) for a median of ten years of annual follow-up.
RESULTS: Of 251 patients with HER2-positive breast cancer, 46 (18.3%) and 205 (81.7%) were classified into the HH and LH groups, respectively. The HH group had more distant metastases and a poorer prognosis than the LH group (DFS: P < 0.001 (HH:63% vs LH:91% at 10 years), and OS: P = 0.012 (HH:78% vs LH:95% at 10 years).
CONCLUSION: High HER2 heterogeneity is a poor prognostic factor in patients with HER2-positive breast cancer. A novel approach of heterogeneity, which is manifested by the shape of HER2 FISH distributions, might be clinically useful in the prognosis prediction of patients after HER2 adjuvant therapy.
The Impact of Psychological Health on Childhood Obesity: A Cross-Developmental Stage Analysis
Authors: Feretzakis Georgios , Harokopou Athanasia , Fafoula Olga , Balaska Athina , Koulountzou Antriana , Katoikou Efstathia , Anastasiou Athanasios , Zagkavieros Georgios , Dalainas Ilias , Gkritzelas Georgios
Published: February 2024

This research ventures into the critical public health challenge of childhood obesity by exploring the dynamic interplay between psychological well-being and Body Mass Index (BMI) throughout various developmental stages of childhood. It delves into how emotional regulation, attachment dynamics, and social relationships correlate with obesity from early childhood to adolescence. Highlighting key findings, such as the negative correlation between psychological resilience and higher BMI in young children, the impact of social relationships on obesity risk during pre-adolescence, and the link between adaptive emotional strategies and higher BMI in adolescents, this study brings to the fore the nuanced relationship between psychological factors and obesity. Utilizing the interdisciplinary process of bioinformatics, this research synergizes psychometric and biomedical data to unearth psychological markers critical for crafting targeted, age-appropriate interventions. This study advocates for a holistic healthcare approach, emphasizing the integration of psychological support within obesity prevention and management strategies, thereby underscoring the indispensable role of psychological factors in the fight against childhood obesity. The application of bioinformatics methods to analyze complex datasets demonstrates how collaboration across medical specialties can enrich our understanding and response to childhood obesity, contributing significantly to the development of comprehensive, bioinformatics-enhanced healthcare solutions.
A Review on the Promising Antibacterial Agents in Bone Cement-from Past to Current Insights
Authors: Lin Hao , Gao Zhe , Asilebieke Ayakuzi , Guo Rui , Kan Yu-chen , Wang Zhi , Han Lu-yang , Bo Wen-han , Han Long-xu , Qi Yan-yu , Xu Yang , He Fang , Chu Jian-jun
Published: February 2024

Antibacterial bone cements (ABCs), such as antibiotic-loaded bone cements (ALBCs), have been widely utilized in clinical treatments. Currently, bone cements loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release and bacterial resistance. Therefore, there is a demand for the development of antibacterial bone cements containing novel agents. In this review, we summarize the latest advancements in ABCs. More importantly, we provide an overview and outlook on novel antibacterial agent-loaded bone cements, including metallic antibacterial agents, pH-switchable antibacterial agents, cationic polymers, N-halamines, non-leaching acrylic monomers, antimicrobial peptides, etc. Offering novel perspectives for designing ABCs and treating bone infections.
Influence of Workpiece Submerging Velocity on Current and Power in Plasma Electrolytic Polishing
Authors: Valentinčič Joško , Zeidler Henning , Böttger Toni , Jerman Marko
Published: February 2024

Plasma electrolytic polishing (PeP) is mainly used to improve the surface quality and thus the performance of electrically conductive parts. It is usually used as an anodic process, i.e. the workpiece is negatively charged. However, the process is susceptible to high current peaks during the formation of the vapour skin especially when polishing workpieces with a large surface area. In this study, the critical influence of workpiece submerging velocity on the current peaks and the average power during the initialisation of the PeP process is investigated for a workpiece size of microreactor mould insert. Through systematic experimentation and analysis, this work provides insights into the control of the initialisation process by modulating the workpiece submerging velocity. The results clarify the relationship between submerging velocity, peak current and average power and provide a novel approach to improve process efficiency in PeP. The highest peak current and average power occur when the electrolyte splashes over the top of the workpiece and not, as expected, when the workpiece touches the electrolyte. By submerging the workpiece while the voltage is applied to the workpiece and counter electrode, the reduction in both parameters is over 80 %.
Best Practices to Train Accurate Deep Learning Models: A General Methodology
Authors: Moyano Alberto , Maitín Ana , J. García-Tejedor Álvaro
Published: February 2024

In recent years the field of computer science has experienced great changes, due to the incredible advances in the field of artificial intelligence. Deep Learning models are responsible for most of them since the biggest milestones occurred in 2012 when AlexNet won the image classification challenge called ImageNet. These models have demonstrated great performances in different types of complex tasks like image restoration, medical diagnosis or object recognition. Their disadvantages are related to their high data dependency, which forces experts in the field to follow a precise methodology to obtain accurate models. In this paper, we describe a complete workflow that begins with the management of the raw data until the in-depth interpretation of the performance of the models. This should be taken as a high-level consultation document describing good practices that should be applied. Apart from the step-by-step methodology, we present different use cases that correspond to the two main problems of the field: classification and regression.
Abnormal Static Sagittal Cervical Curvatures Following Motor Vehicle Collisions: A Retrospective Case Series of 41 Patients before and after Collision with Clinical Implications
Authors: Haas Jason W , Oakley Paul A. , Ferrantelli Joseph R. , Katz Evan A. , Moustafa Ibrahim M. , Harrison Deed E.
Published: February 2024

Background: Previous investigations have found a correlation between abnormal curvatures and a variety of patient complaints such as cervical pain and disability. However, no study has shown that loss of the cervical curve is a direct result of exposure to a motor vehicle collision (MVC). This investigation presents a retrospective consecutive case series of patients with both a pre-injury cervical lateral radiograph (CLR) and a post-injury CLR after exposure to a MVC. Computer analysis of digitized vertebral body corners on CLRs was performed to investigate the possible alterations in the geometric alignment of the sagittal cervical curve. Methods: Three spine clinic records were reviewed, over a 2-year period, looking for patients where both an initial lateral cervical x-ray and an examination were performed prior to the patient being exposed to a MVC; afterwards an additional exam and radiographic analysis were required. A total of 41 patients met the inclusion criteria. Examination records of pain intensity on numerical pain rating scores (NPRS) and neck disability index (NDI), if available, were analyzed. The CLRs were digitized and modeled in the sagittal plane using curve fitting and the least squares error approach. Radiographic variables included total cervical curve (ARA C2-C7), Chamberlain’s line to horizontal (skull flexion), horizontal translation of C2 relative to C7, segmental translations (retrolisthesis and anterolisthesis), and circular modelling radii. Results: There were 15 males and 26 females with an age range of 8-65 years. Most participants were drivers (28) involved in rear end impacts (30). The pre-injury NPRS was 2.7 while the post injury was 5.0; p < 0.001. The NDI was available on 24 /41 (58.5%) patients and was found to increase following exposure to the MVC: 15.7% to 32.8%, p < 0.001. An altered cervical curvature was identified following exposure to MVC, characterized by an increase in radius of curvature and an approximate 8° reduction of lordosis from C2-C7; p < 0.001. The mid cervical spine (C3-C5) showed the greatest curve reduction with localized mild kyphosis at these levels on average. Several participants developed segmental translations that approached the instability value of translation > 3.5mm. Conclusions: Abnormalities of cervical lordosis occurred following exposure to a MVC. The average loss of cervical curvature was 8° from C2-C7, with mild flexion of the mid cervical segments. Snap through type or dynamic buckling during the MVC may explain our findings. The primary contribution of this study to the motor vehicle collision literature is that altered cervical lordosis may result from MVC exposures and the consequences of an altered cervical alignment, in turn, may lead to future pain, disability and decreased health-related quality of life.
Toward Enhanced Plant Immunity: Unveiling the Role of Brassinosteroids in Abiotic and Biotic Stress Response
Authors: Sawicka* Barbara , Barbaś Piotr , Bienia Bernadetta , Skiba Dominika , Pszczółkowski Piotr , Krochmal-Marczak Barbara
Published: February 2024

Abstract: Brassinosteroids (BR) are essential plant hormones that play a crucial role in regulating plant growth and development, as well as their resistance to abiotic and biotic stresses, including pathogen infections. In the context of plant im-munity, BR influence various processes such as the expression of genes related to pathogen defense, the production of antimicrobial compounds, and the re-inforcement of the plant cell structure. The aim of work is understand the role of BR in plant defense against abiotic and biotic stresses. BR are involved in the regulation of metabolic processes, water economy, and photosynthesis, contributing to increased plant resistance to abiotic stresses. The study discusses various mechanisms of BR action on plant immunity, including the regulation of gene expression related to defense, activation of the plant defense system, in-teraction with other plant hormones, regulation of water and salt balance, and influence on photosynthetic processes. In the context of plant immunity, BR influence various processes, including the expression of genes related to pathogen defense, the production of antimicrobial compounds, and the reinforcement of the plant cell structure. Additionally, BR are involved in the regulation of metabolic processes, water economy, and photosynthesis, con-tributing to increased plant resistance to abiotic and biotic stresses. The paper emphasizes the importance of further research on the role and mechanisms of action of BR in plant immunity, which may contribute to the development of more effective strategies for the use of BR in agriculture, horticulture, and plant protection.
Cabbage (Brassica oleracea var. capitata) Development in Time: How Differential Parenchyma Tissue Growth Affects Leafy Head Formation
Authors: Liu Zihan , Aleman Baez Jorge , Visser Richard , Bonnema Guusje
Published: February 2024

This study aims to categorize the morphological changes during cabbage (B. oleracea ssp. capitata) development: seedling, rosette, folding, and heading and to elucidate the cellular mechanisms of leaf curvature, essential for the formation of the leafy head. We followed the growth of two cabbage morphotypes with distinct head shapes (round and pointed); we phenotyped the size and volume of the whole-plant as well as the size, shape, and curvature of the leaves during growth. By integrating these phenotypic data, we determined the four vegetative stages for both cabbages. Cytological phenotypes of microtome sections from five distinct leaf positions of the rosette, folding, and heading leaves at two timepoints during leaf growth were quantified and revealed variations in cellular parameters among leaf types, between leaf positions, and between the adaxial and abaxial sides. We identified two synergistic cellular mechanisms contributing to the curvature of heading leaves: differential growth across the leaf blade, with increased growth at the leaf's centre relative to the margins; and increased expansion of the spongy parenchyma layer compared to the palisade parenchyma layer, resulting in the direction of the curvature, which is inwards. These two processes together contribute to the typical leafy heads of cabbages.
Objective Dimensions on Fishermen's Quality of Life
Authors: Laratmase Antonia Junianty , Rahmani Sofia Fitri , Wahyuari Wahyuari
Published: February 2024

The purpose of this study was to find out fishermen’s quality of life construct validity used survey by involving 44 fishermen in Cimalaya, Karawang. Data analyzed by correlations test, cronbach’s alpha and factor analysis (CFA). The Study results revealed that there were four objective dimensions of fishermen’s quality of life that can be seen from the indicators: (1) income with value of 0.455; (2) Marital status with value of 0.545; (3) Health status with value of 0.691; and (4) Social relationship with value of 0.638. Those values were good since they were above 0.4 or had little tolerance to above 0.25. For this reason, the objective dimensions of quality of life can be measured in terms of harmony and ability which is the integration of quality of life.
Cohesion and Coherence in Remarks by President Biden in the Joint Statement with Ukraine
Authors: M. Bryant Valen Febrian  , Raissa Putri Ardani  , Rizky Agus Musyahid  , Wiryawan Maulana
Published: February 2024

This research paper focuses on the analysis of cohesion and coherence in the remarks made by President Biden during the Joint Statement with Ukraine. The study aims to examine the logical flow, consistency, and clarity of President Biden's statements in the context of the U.S.-Ukraine relationship. A content analysis approach is employed to analyze the speech delivered by President Biden, including key themes, messaging, and any potential inconsistencies. The findings of this analysis contribute to understanding the effectiveness of President Biden's communication strategy and the coherence of his administration's approach toward Ukraine. The analysis presents a comprehensive understanding of the cohesion and coherence exhibited by President Biden in the Joint Statement with Ukraine, offering valuable insights into the U.S. government's stance towards Ukraine and its broader foreign policy objectives. The findings of this research provide valuable insights into the effectiveness of President Biden's communication strategy and the coherence of his administration's approach toward Ukraine. By assessing the cohesion and coherence in President Biden's remarks, this analysis offers a comprehensive understanding of the administration's commitment to supporting Ukraine in various domains, including security, democracy, and economic development.
Accuracy of the Lesser Trochanter Profile as a Marker of Femoral Rotation
Authors: Jang Eugene S. , Davignon Robert , Geller Jeffrey A. , Cooper H. John , Shah Roshan P.
Published: February 2024

Background:

The lesser trochanter (LT) profile is an often-used marker for proximal femoral rotation, particularly during the operative fixation of femoral fractures. Previous studies have come to conflicting conclusions about its reliability for this purpose.

Methods:

The SOMA (Stryker Orthopaedic Modeling and Analytics) database (Stryker) was used to identify 1,722 computed tomographic (CT) scans of whole femora. Each femur was taken through an 80° rotational arc in 2.5° increments, and the LT profile was constructed for each position. These 56,826 LT profile measurements were then correlated with the femoral rotation.

Results:

Across the arc of motion studied, the LT correlated weakly with proximal femoral rotation (R2 = 0.32). There was a 35° arc, between 10° and 45° relative external rotation of the proximal femur, within which the LT profile only changed by 1 mm. The mean overall femoral anteversion was 21.2°, and women tended to have more femoral anteversion (23.9°) than men (19.2°). On average, men had a 1.6-mm more prominent LT than women. Side-to-side differences in femoral anteversion as well as LT position and size were not significant or were clinically unimportant.

Conclusions:

A large-scale, CT-based study shows that the LT profile is a less reliable marker of proximal femoral rotation than previously thought. This is true particularly if there is relative external rotation of the proximal femur, where the proximal femur can undergo up to 35° of rotation before 1 mm of change in the LT profile occurs. Care must be taken to check other markers of rotation such as by clinical examination during fixation of femoral fractures and not rely solely on the LT profile.

Clinical Relevance:

In the largest study of its kind, this CT-based study of 56,826 LT profile measurements found that when the proximal femur is externally rotated, the LT profile becomes an unreliable marker of rotation, which can lead to excessive internal rotation of the distal fracture fragment. The LT profile should be used with caution, and confirmation of rotation by other means is recommended.
Cinderella’s Princely Ever After
Authors: Brock-Servais Rhonda
Published: February 2024

This paper focuses on three film adaptations of “Cinderella” that appeared in the late 1990s and early 2000s: Ever After: A Cinderella Story (1998), A Cinderella Story (2004), and Another Cinderella Story (2008). Close reading the details of the movies, particularly the presentation of the Cinderella characters, the relationships between women, and the role that men play, reveals problematic ideologies about gender and power. All these films are postfeminist adaptations of the Cinderella story that have a veneer of girl power and independence, but actually suggest that most females are not trustworthy and that true power lies with the masculine.
Artistic Work for Children between Productive and Social Reproductive Work
Authors: Kobolt Katja
Published: February 2024

Drawing on professional discourses, the organisation, and status of artistic production in publishing for children in socialist Yugoslavia (1945–1991) and by the conceptual bridging of social reproduction theory, this article turns to artistic work for children as productive and social reproductive work and to the social construction of its value in order to reflect on the reasons of the relative feminisation of this work.
Koralina Neila Gaimana
Authors: Matek Ljubica , Prtenjača Zvonimir
Published: February 2024

Nagrađivani dječji roman Koralina [Coraline] Neila Gaimana objavljen 2002. primjer je hibridne i ukrižene književnosti jer objedinjuje teme i motive različitih književnih žanrova s ciljem pripovijedanja osnažujuće priče o odrastanju, jednako zanimljive djeci i odraslima. Koristeći se književnim odrednicama gotičke književnosti, fantazije i Bildungsromana, Gaiman pripovijeda priču o djevojčici koja u novom domu otkriva tajna vrata, ulaz u paralelni, mračan svijet prepun opasnosti, u čem vidi poziv na junačko putovanje. Spašavajući vlastite roditelje i samu sebe, Koralina pronalazi vlastiti identitet, ali pronalazi i zadovoljstvo i ljubav u onima koji ju okružuju. Konstituirajući Koralinu kao nomadski subjekt, roman prikazuje tijek odrastanja kao afirmativan proces, iako ga prate brojni izazovi i neugodna iskustva. Time se potvrđuje teza da gotička književnost za djecu ima pozitivne recepcijske učinke, za razliku od gotičke književnosti za odrasle koja za cilj ima destabilizaciju subjekta i propitivanje društva i svijeta.
Plan de negocios para la producción y venta de artículos decorativos funcionales con base en materiales reutilizados en el ámbito de Lima Moderna
Authors:   , Avalos Gonzales Karina Stefani , Figueroa Manrique Geovanna Melisa , Laos Alegría Raúl Eduardo , Sandoval Ayala Cinthya Jesarela , Ugarte Noriega Carolina Gisella
Published: February 2024

La intención del presente proyecto es crear una empresa de accesorios de decoración del hogar funcional enfocada en el uso de materiales reciclados y productos amigables con el medio ambiente. En primera instancia, se contará con cuatro líneas de productos: Pedestales, mesas, luminarias y bancos fabricados con maderas recuperadas de demolición de casas y/o recogidas de las playas, bosques, puertos, etc. Con esta práctica se cumple con el objetivo de contribuir con la gestión responsable de desechos y reducir la tala excesiva de árboles. Además, la utilización de estos materiales supone que cada pieza tenga características únicas definidas por el desgaste particular de cada pieza de madera. Así, aunque los modelos se repitan, cada pieza será única e irrepetible. Tenemos como objetivo cubrir las necesidades de un sector del mercado interesado en una decoración original y acogedora. Tendencia que se vuelve más viable en una ciudad como Lima en la que la gestión de residuos aún se encuentra atendida solo para ciertos materiales. La ventas de los productos fabricados será vía online a través de redes sociales, por lo que no se contará con física, lo que contribuirá a que la inversión inicial no sea considerable. Para ello, se elaborará un plan de marketing de redes sociales, operaciones, recursos humanos y financiero para evaluar la viabilidad del proyecto.
Citomegalovirus congénito: Características perinatales, clínicas, terapéuticas y secuelas neurológicas en un hospital nacional de Lima, Perú 2010-2020
Authors:   , Eyzaguirre Sandoval Miguel Eduardo
Published: February 2024

Introducción: La infección congénita por citomegalovirus (CMVc) es la causa no genética más común de pérdida auditiva neurosensorial y una causa importante de trastornos del neurodesarrollo en infantes. Tiene mayor prevalencia en países en vías de desarrollo. Objetivo: Describir las características perinatales, clínicas, terapéuticas y las secuelas neurológicas de los pacientes con CMVc atendidos en el Hospital Nacional Docente Materno Infantil “San Bartolomé” (HONADOMANI) en el periodo 2010-2020. Pacientes y método: Se revisaron las historias clínicas de los pacientes pediátricos que estaban registradas con los códigos CIE-10 de “enfermedad por citomegalovirus, no especificada” (B25.9) e “infección citomegalovírica congénita” (P35.1) atendidos entre los años 2010 y 2020. Se incluyeron a los pacientes con diagnóstico por laboratorio de CMVc nacidos en el HONADOMANI. Se recolectaron datos de la madre, el periodo gestacional, perinatal y seguimiento de cada paciente. Resultados: 15 pacientes fueron incluidos, de los cuales 13 pacientes fueron sintomáticos, 9 de sexo masculino y 6, femenino. La presentación clínica más reportadas fueron microcefalia (53,8%) y pequeño para la edad gestacional (46,7%). Trece (86,7%) de los pacientes tuvieron tamizaje auditivo y 23% reportó pérdida auditiva, sin secuela posterior. Cinco pacientes mantuvieron alguna secuela del neurodesarrollo. La ecografía cerebral fue el estudio imagenológico más realizado. 40% de los pacientes recibieron tratamiento con ganciclovir y valganciclovir, dos de ellos en su primer mes de vida. Conclusión: Este reporte de serie de casos provee información sobre la situación local en el diagnóstico, manejo y secuelas de la infección congénita por citomegalovirus.
Factores de riesgo asociados a Síndrome de Apnea Obstructiva del Sueño en pacientes adultos mayores: un análisis bibliométrico latinoamericano 2000-2020
Authors:   , Latorre Araujo Maria Cristina , Jessen Espinoza Natalí Ximena
Published: February 2024

Introducción: El síndrome de apnea hipopnea obstructiva del sueño (SAHOS) se caracteriza por el cierre parcial o total de las vías respiratorias durante el sueño. Tiene mayor prevalencia en adultos mayores y está asociada a hipertensión, accidentes cerebrovasculares y diabetes. Objetivo: Describir los indicadores bibliométricos de las publicaciones científicas latinoamericanas relacionadas a los factores de riesgo en pacientes adultos mayores con SAHOS. Materiales y Métodos: Este estudio bibliométrico evaluó la producción científica latinoamericana sobre SAHOS en adultos mayores (≥60 años) y sus factores de riesgo en el periodo de 2000-2020 que se encuentran en la base de datos de Scopus. Resultados y conclusiones: Seis artículos cumplieron los criterios de selectividad. Todos se encuentran en revistas diferentes. El país que más publicaciones realizó es Brasil (4). La mayoría de las publicaciones se encuentran en inglés (4). Todos los estudios son observacionales, cinco con diseño transversal y uno con diseño retrospectivo. El artículo más antiguo fue publicado en el año 2006, ha sido citado 16 veces y está en una revista con índice H 50. El artículo con mayor número de citas tiene 513 y fue publicado en el 2010. Los artículos más recientes no fueron citados hasta el momento de recolección de datos. Evidenciamos la escasa producción de artículos a pesar de la importancia de los factores de riesgo para SAHOS en adultos mayores. En Latinoamérica, Brasil es el que más publica y sus artículos tienen el mayor número de citas.
CARBON STOCK, RATES OF CARBON ACCUMULATION AND DISTRIBUTION OF PARTICLES IN A LAKE OF THE ANAVILHANAS ARCHIPELAGO, NEGRO RIVER - AMAZON DURING THE LAST 1900 YEARS
Authors: Cunha Silva Vanessa , Aniceto Keila , Rocha Maia Caroline , Campello Cordeiro Renato , Moreira-Turcq Patricia , Silva Moreira Luciane , J. Sanders Christian , Marotta Humberto , Turcq Bruno
Published: February 2024

Recent studies show that, despite great variability, the lake systems of the Amazon Basin have presented significant results in the accumulation and storage of organic carbon (TOC). However, the demonstration in the region is still limited and lacks more data to better estimate this non-carbon component of the region. The objective of this article was to estimate the carbon stock, the carbon accumulation rates and characterize the granulometric distribution of an Amazonian lake located in the Anavilhanas Archipelago, in the Lower Negro River region. Data were carried out using the 14C method and analyses of density, granulometry and TOC rate sof samples of a sediment core 1 meter deep. The results have shown that, during the period of 1900 cal years BP, Lake Boto presented two isolated peaks of sand particle sedimentation possibly related to major hydrodynamic events. Generally, well-defined characteristics of a lacustrine environment with sedimentation of fine silt and clay particles predominate. The sedimentation rate was 0.03 cm.year-¹ between approximately 1900 to 850 cal years BP and 0.07 cm.year-¹ in the last 850 cal years BP. It is estimated that Lake Boto has a stock of approximately 231,000 tons of TOC accumulated during the entire period. The stock of TOC is not significant as it is estimated for the soils of the Amazon. The results are an important indication of the role of the Anavilhanas Archipelago as a TOC sink.
Coupled Geomechanics and Chemistry Model for Acid Stimulation of Naturally Fractured Carbonate Reservoirs
Authors: Chuprakov Dmitry , Peshcherenko Aleksandra , Anisimov Mikhail
Published: February 2024

Treatments of naturally fractured carbonate formations typically involve acid injection when damage of natural fractures (NFs) occurs mechanically and chemically. Coupled modeling of both mechanisms is often neglected. We build a quantitative model of damageable reservoir, where the permeability depends on the shear and tensile activation of NFs, as well as acid transport and reaction. Simulations demonstrate model applicability to NF acidizing and acid fracturing. Particularly, we show that strong pressure drawdowns in tight carbonates result in steep production declines because of NF pinching.
WITHDRAWN: Hierarchical Attentive Feature Aggregation for Person Re-identification
Authors: Dong Husheng , Lu Ping
Published: February 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in ctDNA with Engineered Advanced-Fidelity FnCas9
Authors: Hur Junseok , Ye Sunghyeok , Won Yoon-Ho , Park Taegun , Jeong Haerin , Kang Shin Jae , Hong Ju Yeon , Chung Hee-Joon , Lee In Seon , Choi Hyun Jeung , Rhee Jae Won , Kim Jin-Soo , Kim Mi Young , Kim Myungshin , Kim Yonggoo , Lee Sungho , Chung Jae Ho , Gim Jeong-An , Hwang Woochang , Hur Junho , Kim Ki-Yeon
Published: February 2024

In this study, we present the development of the Mutation tagging by CRISPR-based Ultra-precise Targeted Elimination in Sequencing (MUTE-Seq) method. We engineered a highly precise advanced-fidelity FnCas9 variant, named FnCas9-AF2, to effectively discriminate single-base mismatches at all positions of the single guide RNA (sgRNA) target sequences. FnCas9-AF2 exhibited significantly lower off-target effects compared to existing high-fidelity CRISPR-Cas9 variants. We developed MUTE-Seq by applying FnCas9-AF2 for enrichment of mutant DNA without sequence limitations via the exclusive cleavage. The depletion of perfectly matched wild-type DNA targets offered a sensitive detection method for low-frequency cancer-associated mutant alleles. MUTE-Seq enabled sensitive monitoring of minimal residual disease (MRD) from the bone marrow of patients with Acute Myeloid Leukemia (AML). Furthermore, MUTE-Seq was applied in a multiplexed manner on cell-free DNA (cfDNA) from patients diagnosed with non-small cell lung cancer (NSCLC). Multiplexed MUTE-Seq (mMUTE-Seq) resulted in a significant improvement in the sensitivity of simultaneous mutant detection and was also effective for stage I NSCLC patients with extremely low levels of circulating tumor DNA (ctDNA). We anticipate that the FnCas9-AF2-based MUTE-Seq method could offer a valuable clinical tool to facilitate improved molecular diagnosis, prognosis evaluation, and treatment planning for cancers in various stages.
Learning to Suppress Tremors: A Deep Reinforcement Learning-Enabled Soft Exoskeleton for Parkinson's Patients
Authors: Tamás Endrei , Földi Sándor , Makk Ádám , Cserey György
Published: February 2024

Neurological tremors, prevalent among a large population, are one of the most rampant movement disorders. While biomechanical loading and exoskeletons show promise in enhancing patient well-being, traditional control algorithms limit their efficacy in dynamic movements and personalized interventions. Furthermore, there exists a pressing need for more comprehensive and robust validation methods to ensure the effectiveness and generalizability of proposed solutions. This paper proposes a physical simulation approach modelling multiple arm joints and tremor propagation. This study also introduces a novel adaptable reinforcement learning environment tailored for disorders with tremors. Furthermore we present a deep reinforcement learning based encoder-actor controller for Parkinson's tremor present in various shoulder and elbow joint axes, displayed in dynamic movements. We found that the controller is capable of suppressing tremors in all recorded dynamic movements. The control achieves an average tremor of over 57.43% for three out of the four distinct movement trajectories. Notably, the controller attains a maximum accuracy of 99.49%. Our findings suggest that a deep reinforcement learning based control strategy offers a viable solution for tremor suppression in real-world scenarios. By overcoming the limitations of traditional control algorithms, this work takes a new step in the adaptation of biomechanical loading into the everyday life of patients. This work also opens avenues for more adaptive and personalized interventions in managing movement disorders.
Local factors mediate climate and land use effects on global fire regimes (2003-2020)
Authors: Mahood Adam , Tuff Ty , Cattau Megan , Iglesias Virginia , Hanson Thomas , Stephens Jilmarie , Ilangakoon Nayani , Cook Maxwell , nagy Chelsea , Barnard David , Stavros Natasha , DeCastro Amy , Balch Jennifer
Published: February 2024

Changes in fire activity challenge policymakers, land managers and the general public. Burned area (BA) is declining globally, but 81% of BA occurs in just 22 countries, and growth rate may be more important for public safety. We used eight fire regime components from country-level datasets to characterize fire regimes for 241 countries from 2003-2020. Fire regimes followed two axes of variation, with BA versus event duration on one axis, and season length versus event size and spread rate on the other. Annual trends in fire regime components were mixed, with no trend being most common, as expected given the short time series. Increases in fire activity were associated with increases in aridity in boreal, temperate and equatorial countries, and with land cover changes in arid countries. But these associations explained <40% of model variation, indicating that local and regional circumstances are more important than broad generalizations from global models.