bluuebunny/crossref_metadata_2025 huggingface dataset:
Music making and the potential impact for a child in foster care
Authors: Humphrey Ryan
Published: February 2019

The United Kingdom has seen an increasing number of children entering the looked after care system (foster care, adoptive care or residential care). Due to this increasing number, there have been several music projects set up in the United Kingdom, which aim to provide opportunities for musical engagement for looked after children. This article aims to examine the impact that a music project has on children in foster care and their carers. Using a case study strategy to examine the Loud and Clear project based at Sage Gateshead, this research took on a multi-methodological approach. Focus groups and interviews were constructed to collect the narratives of participants’ experiences of attending the project and to identify the impacts the project may be having. Additionally, participatory observations were also undertaken to see first-hand the approaches that the facilitators were using within sessions to meet the needs of the participants. Findings indicated that attending a music project helped facilitate a sense of structure for foster children while also providing unique opportunities for carers to socialize with one another – these being two key areas that are often lacking in participants’ lives, that can be seen to be overcome through active participation within a music project.
Continuing Medical Education Questions: February 2019
Authors: Carpenter Steven L.
Published: February 2019

To receive CME/MOC credit for this activity, please go to: http://acgjournalcme.gi.org/

Article Title: Opportunities to Prevent Alcoholic Liver Cirrhosis in High-Risk Populations: A Systematic Review and Meta-Analysis
Temps narré et temps existentiel dans Œdipe sur la route d’Henry Bauchau
Authors: BEGENAT NEUSCHAEFER Anne
Published: February 2019

Anne Begenat-Neuschaefer présente dans cet article une réflexion sur le traitement de la temporalité dans le roman Œdipe sur la route. Il faut que le lecteur suive l’auteur dans le labyrinthe imaginaire de la pré-histoire et accepte l’effacement de la temporalité. Ainsi gagne-t-il, en arpentant le chemin, un nouvel ordre temporel souverain en se donnant lui-même le temps que Bauchau prit pour l’écriture d’Œdipe sur la route. Se donner du temps, c’est le grand don qu’on doit se faire, celui qu’attend l’inconscient pour prendre confiance et se manifester. Le véritable hypotexte est l’inconscient que le poète ne peut rencontrer que dans un acte de liberté établissant confiance et liberté.
La compagnie du peintre
Authors: BAUCHAU Henry
Published: February 2019

Textes inédits dédiés au peintre Suzanne Van Damme par Henry Bauchau et inspirés par la fréquentation de son travail plastique
Au cœur de la création artistique : le combat de Jacob avec l’Ange
Authors: CAULLIER Joëlle
Published: February 2019

Joëlle Caullier nous propose dans cet article une analyse partant de la référence, importante pour l’écrivain, du tableau de La Lutte avec l’Ange de Delacroix (exposé dans une des chapelles latérales de l’église Saint-Sulpice à Paris) pour décrire dans les personnages de Bauchau l’homme en prise avec son hybris et ses penchants violents, le travail de ré-apprivoisement du versant sombre par le versant lumineux de l’être par le truchement de l’art, voie possible de réconciliation de l’individu et de la société, du singulier, si singulier soit-il, et du collectif.
Quelques lettres inédites de la correspondance entre Philippe Jaccottet et Henry Bauchau
Authors: BAUCHAU Henry
Published: February 2019

Echange épistolaire entre Henry Bauchau et Philippe Jaccottet, à qui il a dédié le premier poème éponyme de son premier livre, Géologie
Poèmes inédits d’Henry Bauchau
Authors: BAUCHAU Henry
Published: February 2019

Avant-textes liés au recueil La Dogana. Poèmes vénitiens (1965)
Un écrit inédit d’Henry Bauchau : la « traduction » d’une idée préliminaire pour Œdipe sur la route
Authors: MASTROIANNI Michèle
Published: February 2019

Michele Mastroianni s’interroge sur ce que signifie Henry Bauchau lorsqu’il se dit « le traducteur infidèle » de quelque chose qui a voulu parler à travers lui dans le moment de l’inspiration. Pour ce faire, il analyse comparativement la première et la deuxième version d’Œdipe sur la route, sur le plan des variations lexicales et syntagmatiques. L’analyse structurelle révèle les mécanismes d’intratextualité propres à l’écrivain, et repère cinq mouvements fondamentaux dans son processus d’écriture.
Pour une poésie de circonstance
Authors: BELIN Olivier
Published: February 2019

Partant du constat que l’écriture poétique coexiste sans cesse chez Henry Bauchau avec des formes génériques romanesque, théâtrale, diariste, etc. qu’elle accompagne ou prolonge, l’étude observe le poème non comme un texte de circonstance, mais comme la circonstance même, obligeant le poète à vivre en fonction de son exigence. Le temps énonciatif se dilate en parcourant le présent, le passé et le futur, jusqu’à les englober dans une osmose. Il s’agit ainsi d’accepter le devenir temporel pour en faire le point de départ d’une recherche toujours recommencée.
du Grand Temps à l’a-chronie narrative.
Authors: AMMOUR-MAYEUR Olivier
Published: February 2019

L’analyse s’attache à la stratégie d’interruptions des temps narrés dans le roman La Déchirure. Elle montre la coprésence des valeurs narratives temporelles du Grand Temps mythique (renvoyant à la Genèse) et du présent d’incertitude du Moi écrivant. Elle interprète ce dispositif comme la restructuration, grâce au remembrement textuel, du Moi disséminé du narrateur.
La présence du rêve dans les journaux personnels d’Henry Bauchau
Authors: PIBAROT Annie
Published: February 2019

L’article fait le point sur la présence des récits de rêve dans l’ensemble diariste de cet écrivain psychanalyste qu’est Henry Bauchau : leur fréquence, leur mode d’annonce, leurs contenus récurrents, leur fonction et leur statut : avant-textes, textes-origine, ou déjà séquences littéraires à part entière, faisant droit à une pensée par images et autorisant un autre type de temporalité.
« Un long travail d’échiquier » : enquête sur les brouillons de La Mer est proche
Authors: LEMAÎTRE Sophie
Published: February 2019

L’article se penche sur les traces de la genèse du recueil La Mer est proche, ensemble de dix poèmes sur des tableaux de Paul Delvaux commandé à Henry Bauchau par René Micha, en vue de les intégrer au film d’Henri Storck sur le peintre belge. La rédaction s’opère entre 1969 et 1972, moment où Henry Bauchau côtoie de près plusieurs artistes et s’adonne lui-même au dessin. L’expérience de l’écriture de commande s’avèrera contraignante et le film, dans lequel les vers ont été éparpillés, perdant leur sens, s’avèrera décevant pour l’auteur.
« Ce que je pense depuis quelque temps, c’est que votre œuvre a du pouvoir ».
Authors: BAUCHAU Henry
Published: February 2019

Quelques réponses d’Henry Bauchau à l’abondante correspondance de Gisèle Sallin, directrice du Théâtre des Osses à Givisiez (Suisse) concernant des adaptations au théâtre de Diotime et les lions, Œdipe sur la route, Antigone. Henry Bauchau répond aux propositions de mise en scène, mais aussi de manière plus personnelle, par des poèmes, notamment. Choix, présentation et commentaires par Pauline Basso et Jérémy Lambert (jeremy-lambert@hotmail.com).
Les échos d’Antigone. De la voix au visage
Authors: SIFFERT Elsa
Published: February 2019

Analyse de l’opéra La lumière Antigone se référant aux théories de Lacan. L’ensemble de la production littéraire d’Henry Bauchau est traversé de multiples voix. Parmi elles, plus spécifiquement, une voix sans parole qui n’est pas un vecteur de communication, mais véhicule d’un désir de l’Autre. Cette voix qui exprime l’indicible, est paradoxalement mise en mot dans le dialogue d’Antigone et d’Hannah et trouve un écho dans la musique. «Bauchau intègre le cri d’Antigone, cette poussée extime d’un informulé informulable et agrammatical qui demande pourtant à se manifester. Pierre Bartholomée offre à ce cri, à cette parole Antigone, un monde musical. »
L’archive, devenir et avenir de l’œuvre d’Henry Bauchau
Authors: MAYAUX Catherine
Published: February 2019

L’abondance des ébauches théâtrales conservées dans les archives d’Henry Bauchau amène à considérer trois aspects encore sous-estimés dans l’approche de son œuvre. En premier lieu, sa fascination pour la forme dramatique, épique notamment, mais non suivie d’effets, rappelle que l’auteur aurait voulu être un homme d’action sans réussir dans cette voie. En second lieu, cette partie spectrale ou fantomale de son œuvre entre dans les contours de l’œuvre complète : cette inventivité dramatique, que l’on retrouve dans les autres genres pratiqués, se manifeste dans la théâtralité romanesque ou poétique. Enfin, le 3ème aspect met en évidence l’importance de la voix, intérieure notamment, qui crée différents niveaux de parole et d’écoute.
RNA-Seq Analysis of lncRNAs and cisNATs in the Tomato Genome
Authors: Ather S. Hussain
Published: February 2019

Since the sequencing of the human genome, it has been revealed that the vast majority of DNA does not code for proteins. Instead, these regions of DNA produce long noncoding RNAs (lncRNAs), which have recently been reported to play important roles such as protein regulation and small RNA processing (Wilusz, Sunwoo, & Spector, 2009). The catalog and functions of lncRNAs in the ripening of tomato species (Solanum lycopersicum) are largely unknown. Similarly, the mechanisms of cis-natural antisense transcripts (cisNATs) of proximal complementary RNA strings, which function to inhibit transcription, are also poorly understood (Wang, Gaasterland, & Chua, 2005). Global issues in food production and malnutrition exacerbate the relevance of understanding these biological mechanisms central to the development of fruit. We identified certain functions of lncRNAs and cisNATs in the tomato ripening process using an RNA-Seq pipeline (Wang, Gerstein, & Snyder, 2005). Raw reads from two different stages in the tomato ripening cycle were aligned to a reference genome to test the hypothesis that there would be different expression levels for certain lncRNAs and cis-NATs between the two stages. The two stages were Mature Green, the stage in which the tomato is completely green, and Breaker, the stage in which the tomato shows initial colors of red. Then, the reads were de novo assembled, assessed for coding potential, and annotated by transcript and function. Finally, the results were filtered for lncRNAs (length > 200 bp, ORF < 100 bp, noncoding, expression value > 0) and cis-NATs (sense-antisense pairs, overlap length > 50 bp, differential splice patterns, expression value = 0). Differentially-expressed lncRNAs and cis-NATs between the two stages of development were identified, and their functions were analyzed. However, experimental evidence is necessary to confirm our findings and hypothesize models of cis-NAT mechanisms for further classification and identification.
Becoming God: Cycles of Rebirth and Resurrection in Their Eyes Were Watching God
Authors: Milvert Kaitlynn N
Published: February 2019

This paper reexamines African-American writer and anthropologist Zora Neale Hurston’s presentation of the self in Their Eyes Were Watching God (1937), generally considered one of the most important African-American novels of the twentieth century. Originally criticized by Hurston’s contemporaries as a retrograde folk portrait of African-American life, Their Eyes presents the oral narrative of Hurston’s protagonist, Janie, a woman surrounded by natural and social cycles. Building on the novel’s allusive title and the convergent Biblical and folkloric frameworks of the work, I trace the evolving concept of “God” throughout the novel as external forces continually shape and reshape Janie’s world for her, questioning whether she can retain any individual agency navigating through these cyclical, predetermined pathways. The redefined vision of the individual that emerges from this reading counters the criticism of Hurston’s contemporaries, as Janie herself assumes the role of “God” at the novel’s conclusion and gains the power to create her own cycles, free from external control. I thus argue that the novel transcends its supposed function as a depiction of the African-American self to make a broader, humanistic claim for the power of the individual, not contingent on social distinctions.
The Motivations behind Child Welfare Work
Authors: Dickman Samuel J
Published: February 2019

This report seeks to explore the findings of a qualitative research study concerning the motivations behind child welfare work. Child welfare is a major field within the social work profession that demands a great deal of expertise and effort from workers. Professionals employed as case managers within the child welfare field are held accountable for a wide variety of social work roles, often placing these individuals at risk of emotional trauma and high levels of work-related stress. Due to this, workers who remain in the field for extensive periods of time often experience strong sensations of purpose relative to their work. Our study found that child welfare caseworkers were motivated by altruism and a deep desire to improve the lives of their clients.  They were also kept motivated by the successes that came from time to time. While trials seem to be experienced on a regular basis, child welfare caseworkers generally found their work to be a positive presence within the families they serve. Further research is needed to expound upon the findings of this study.
Decentralization from Above, Dispossession by Recognition: Contradictions in Tanzania's New Wave Land Reforms
Authors: Del Valle Coello Juan José
Published: February 2019

Recent decades have seen a surge in land reform throughout Sub-Saharan Africa, largely described as “new wave” land reforms aiming to promote rural development through decentralization and formal recognition of claims to land. Focusing on Tanzania, a country with historically highly centralized land management, this investigation examines how new legislation, in particular the 1999 Village Land Act, has attempted to address both local concerns and international pressures and evaluates how successful reforms have been in terms of both. This paper analyzes these reforms in the context of neoliberalism and the related “pro-poor growth” model, which advocates for the formalization and marketization of land titles as a long-term solution to rural poverty. It first provides a theoretical background on the debates surrounding land reform strategies and then examines specific examples from reforms in Tanzania.Tanzania’s reforms have been guided both by local grievances (such as lack of clarity and security regarding access to land) and international pressures (desiring, among other things, greater ease of foreign investment and the creation of a rural land market); as such, issues have frequently arisen in attempting to reconcile sometimes contradictory demands and determining priorities. The results of reforms have been mixed. Formalization, in particular, has shown the potential to exacerbate inequality instead of reducing it, and the process of formalization itself can lead to an increase in conflict over land. However, reforms have also opened new avenues for previously marginalized groups, such as pastoralists, to secure land access through participation in civil society.
Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer
Authors: Devanathan Nirupama , Kimble-Hill Ann
Published: February 2019

Epidemiological studies have proposed a link between type II diabetes and cancer via the IGF/insulin signaling pathway, which includes insulin-like peptides (IGF1, IGF2, and insulin), insulin receptors (IR-A, IR-B, IGF1R, and hybrids), and insulin substrate proteins (IRS1-6). In this study, up- and down-regulation of various components in the IGF/insulin signaling pathway are compared to clinical outcomes for cancer patients; the components include diagnosis age, overall survival, tumor invasion and vascularization, and body mass index. It was found that the up-regulation of insulin growth Factor (IGF)/insulin components was associated with overall survival and tumor invasion and vascularization, while the down-regulation of equivalent components was not associated with clinical outcomes assessed in this study. Particularly, the up-regulation of DOK5, IGF2, and IRS2 in colorectal cancer and IGF1R in liver cancer is associated with significantly decreased overall survival. Functional aberrations in either of the two proteins in co-expression pairs were identified for each cancer and correlated with overall survival and diagnosis age. Specific biomarkers proposed in this study will be further analyzed to fine-tune consistent associations that can be translated to reliable prognostic standards for the roles of IGF/insulin signaling pathway modulations that promote cancer.
Language Mode Influences Language-Specific Categorization
Authors: Merritt Haily
Published: February 2019

The present study aims to fill a gap at the intersection of the phenomena of language mode—the state of activation of the bilingual’s languages and language processing mechanisms—and the subset problem—issues learners face when the second language has fewer of some kind of contrast than the first language. When the subset problem is present in second language acquisition, learners may struggle to acquire specific contrasts of a language and may map them incorrectly to their first language. By studying advanced learners of Spanish and considering language mode, we are able to investigate whether learners create separate categories for Spanish vowels—as opposed to simply adapting their English categories—and whether the use of such categories depends on the language being perceived. Spanish and English serve as convenient languages for study of these phenomena because Spanish has fewer vowels than English. With this, we ask: “Does language mode influence language-specific categorization?” To investigate this question, we had native English-speaking, proficient Spanish learners perform an AX task in both English and Spanish, where they identified whether two aurally presented vowel stimuli were the same or different. There was no strong effect of language mode across conditions, but we found that reaction times were significantly slower and that error rates were higher in tasks that included stimuli from more than one language. Thus, we conclude that when multiple languages are activated it is more difficult to process a given language.
Developing Faculty Communities of Practice to Expand the Use of Effective Pedagogical Techniques
Authors: Hoyert Mark , O'Dell Cynthia
Published: February 2019

The scholarship of teaching and learning literature is replete with examples of pedagogical techniques that have been demonstrated to be effective in improving learning, motivation, and student success. The extension of these techniques beyond the original context has tended to be slow, difficult, and incomplete. The following paper examines an intervention designed to encourage the exploration and use of a variety of pedagogical techniques by faculty in a traditional, four-year college faculty within the context of the AASCU Re-imagining the First Year Initiative. Small groups of six to eight faculty, joined and created communities of practice. The groups were known as Pedagogical Interest Groups, or PIGs for short. The faculty read about and analyzed a series of pedagogical techniques and committed to introducing at least one technique into their courses to further explore the techniques. When the techniques were successful, the faculty members redesigned entire classes to expand the impact. The communities of practice were successful in encouraging faculty to explore a wide variety of techniques. The average faculty group explored eight different pedagogical techniques. Faculty were able to use the opportunity to experiment with techniques with the support from their colleagues in their PIG. A dozen techniques were explored across the PIGs and dozens of class sections have been completely redesigned. To date, over 2000 students have experienced redesigned courses. Measures of student success, satisfaction, and interest in those sections have increased. The effort has been accompanied by a robust increase in the campus-wide retention rates. ​
Empowering Faculty to Support Academic Persistence through a Blended, Scholarship-Based Faculty Professional Development Program: The Persistence Scholars Program
Authors: Miller Michelle , Dickson K. Laurie , Koch Rachel L.
Published: February 2019

While it is well-known that faculty-student interaction is key to student success, few institutions have directly leveraged faculty in supporting academic persistence. Many myths about persistence proliferate, and faculty can unwittingly hinder persistence by implementing the wrong kinds of practices. Faculty are most empowered to support student persistence when they understand and care about this issue. They are also better equipped to help when they have a good, current command of the body of knowledge relating to persistence. To address this, we created a blended faculty development program to engage faculty in the scholarship of academic persistence, addressing myths and misconceptions about persistence, and expanding understanding of what it is like to be a first-year student at our university. The Persistence Scholars Program engaged a total of 32 faculty over two semesters, beginning with pre-readings and an in-person daylong workshop followed by an eight or ten-week course. The curriculum was built around a central text, Completing College by Vincent Tinto, and selected empirical and germane articles. Participants engaged in online discussions and two experiential projects, including one that asked them to complete an activity that would enhance their understanding of first-year students’ experiences. Assessments of this program focused on participant ratings of target competencies (e.g., the ability to identify and dispel myths about why students persist), perception of usefulness of different specific assignments and materials, and suggestions for how the program can be refined for future cohorts.
Development of Tourist Village Based on Local Wisdom
Authors: KOMARIAH Neneng , SAEPUDIN Encang , RODIAH Saleha
Published: February 2019

Area of Paledah Village at Padaherang Sub-district in Pangandaran Regency has a potential as rural tourism. The village has interesting natural characteristics, and unique social and cultural life. This potential should be encouraged and developed in accordance with the socio-cultural characteristics of the community. The development of potential community-based tourism is a strategic effort in building the community. Rural tourism development is a long-term and potential investment for the government as the community resources and natural resources are readily available. The purpose of research is to know the development of tourism village based on local wisdom, especially related to the concept of tourism village criteria in Paledah village. This research uses qualitative approach. The data collection technique used interview, observation, F G D, and literature study. It used descriptive data analysis technique and the steps aredata reduction and presentation, and conclusion. Test of Validity and reliability used triangulation process. Informants in this study were the government, tourism village communities, and tourism developers. The number are 9 persons. The results indicate the values of local wisdom in developing agro tourism village in Pangandaran regency is embodied in organizational principles. There are three basic principles: membership is voluntary and open, management is democratic, and self-reliant. Tourism village criteria include attraction, accessibility, public facilities and tourism facilities, community empowerment, and marketing or promotion. Of the five criteria tourism village in Paledah village, two of it have been running well.Those are the attraction of tourism and community empowerment. While the other three criteria still have constraints.
The Hotel Sector as an Important Component of Regional Economic Infrastructure
Authors: NIKOLSKAYA Elena Yurievna , PASKO Olga Vladimirovna , ANIKINA Elena Nikolaevna , DEKHTYAR Galina Maxovna , LEBEDEV Konstantin Anatol'evich
Published: February 2019

This paper is focused on working out a set of areas for the development of the hotel sector as an important component of regional economic infrastructure. The authors establish that the hotel sector is expected to help achieve a set of objectives aimed at resolving existing social issues so as to ensure the well-being of the population and improving people’s standard of living, which include creating new jobs, improving the level and quality of service, boosting income levels for regions’ residents, and ensuring large inflows of foreign and domestic tourists. The paper identifies several unresolved macrolevel issues, including the lack of an integrated strategy for development and a relevant policy in the sector, the imperfect regulatory/legal framework, poor accounting in respect of economic entities, and the unsatisfactory level of quality of hotel services. The authors prove that at the microlevel the current key issues within the hotel sector include poor accommodation availability and the complicated economic conditions in which hotels get to operate these days.
Morita homotopy theory for (∞,1)-categories and ∞-operads
Authors: Caviglia Giovanni , Gutiérrez Javier J.
Published: February 2019

We prove the existence of Morita model structures on the categories of small simplicial categories, simplicial sets, simplicial operads and dendroidal sets, modelling the Morita homotopy theory of

(
∞
,
1
)

{(\infty,1)}

-categories and

∞

{\infty}

-operads. We give a characterization of the weak equivalences in terms of simplicial presheaves, simplicial algebras and slice categories. In the case of the Morita model structure for simplicial categories and simplicial operads, we also show that each of these model structures can be obtained as an explicit left Bousfield localization of the Bergner model structure on simplicial categories and the Cisinski–Moerdijk model structure on simplicial operads, respectively.
A rare case of congenital hyperinsulinism (CHI) due to dual genetic aetiology involving HNF4A and ABCC8
Authors: Apperley Louise , Giri Dinesh , Houghton Jayne A.L. , Flanagan Sarah E. , Didi Mohammed , Senniappan Senthil
Published: February 2019

Background

Congenital hyperinsulinism (CHI) occurs due to an unregulated insulin secretion from the pancreatic β-cells resulting in hypoglycaemia. Causative mutations in multiple genes have been reported. Phenotypic variability exists both within and between different genetic subgroups.

Case presentation

A male infant born at 35+6 weeks’ gestation with a birth weight of 4.3 kg [+3.6 standard deviation score (SDS)] had recurrent hypoglycaemic episodes from birth. Biochemical investigations confirmed a diagnosis of CHI. Diazoxide was started and the dose was progressively increased to maintain euglycaemia. His father was slim and had been diagnosed with type 2 diabetes in his 30s. Sequence analysis identified a heterozygous hepatocyte nuclear factor 4 alpha (HNF4A) mutation (p.Arg245Pro, c.734G>C) and compound heterozygous ABCC8 mutations (p.Gly92Ser, c.274G>A and p.Ala1185Val, c.3554C>T) in the patient. The p.Ala1185Val ABCC8 mutation was inherited from his unaffected mother and the p.Arg245Pro HNF4A and p.Gly92Ser ABCC8 mutations from his father. All three mutations were predicted to be pathogenic. Identification of the HNF4A mutation in the father established a diagnosis of maturity-onset diabetes of the young (MODY), which enabled medication change resulting in improved glycaemic control.

Conclusions

We report a rare patient with CHI due to dual genetic aetiology. Although he is currently responsive to the maximum dose of diazoxide, the long-term prognosis remains unclear.
Severe in utero under-virilization in a 46,XY patient with Silver-Russell syndrome with 11p15 loss of methylation
Authors: Adachi Masanori , Fukami Maki , Kagami Masayo , Sho Noriko , Yamazaki Yuichiro , Tanaka Yukichi , Asakura Yumi , Hanakawa Junko , Muroya Koji
Published: February 2019

Background

Silver-Russell syndrome (SRS) is characterized by growth retardation and variable features including macrocephaly, body asymmetry, and genital manifestations such as cryptorchidism in 46,XY patients.

Case presentation

The patient was born at 39 weeks with a birth weight of 1344 g. Subtle clitoromegaly warranted a thorough evaluation, which disclosed 46,XY karyotype, bilateral undescended testes, and a rudimentary uterus. Because of severe under-virilization, the patient was assigned as female. Failure to thrive, macrocephaly, and body asymmetry led to the diagnosis of SRS, confirmed by marked hypomethylation of H19/IGF2 intergenic differentially methylated region (IG-DMR). From age 9 years, progressive virilization occurred, which necessitated luteinizing hormone-releasing hormone analog (LHRHa) treatment. Gonadal resection at 15 years revealed immature testes with mostly Sertoli-cell-only tubules. Panel analysis for 46,XY-differences of sex development (DSD) failed to detect any pathogenic variants.

Conclusions

This is the second reported case of molecularly proven 46,XY SRS accompanied by severe under-virilization. SRS should be included in the differential diagnosis of 46,XY-DSD.
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies
Authors: Melekoglu Rauf , Yilmaz Ercan , Ciftci Osman , Kafadar Yusuf Taner , Celik Ebru
Published: February 2019

Background

We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls.

Methods

All pregnant women who underwent second-trimester amniocentesis for genetic analysis between January 1, 2016, and January 1, 2018, were enrolled in this study. From this cohort, 22 patients who subsequently experienced spontaneous preterm delivery before 34 weeks of pregnancy formed the study group, and 22 age- and body mass index (BMI)-matched patients without preterm birth constituted the control group.

Results

No significant differences were observed between the preterm birth and control groups in terms of age, BMI, obstetric history of preterm delivery, gestational age at amniocentesis, or indication for amniocentesis. The mean amniotic fluid levels of ADAMTS4 and ADAMTS5 were significantly increased in the preterm birth group compared to the control group (248.3±22.6 and 182.4±19.8 pg/mL, P=0.012; and 198.6±21.6 and 159.1±21.7 pg/mL, P=0.035, respectively). Significantly increased IL-6 and TNF-α levels were also detected in the amniotic fluid of women who experienced spontaneous preterm delivery, relative to controls (142.1±16.2 and 95.8±16.4 pg/mL, P<0.001; and 139.4±12.5 and 89.6±11.2 pg/mL, P<0.001, respectively).

Conclusion

The results of this study imply that increased mid-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α play an important role in the pathophysiology of spontaneous preterm delivery.
Respiratory Exposure to Toxic Gases and Metal Fumes Produced by Welding Processes and Pulmonary Function Tests
Authors: Mehrifar Younes , Zamanian Zahra , Pirami Hamideh
Published: February 2019

Background: Welding is a common industrial process and is harmful to welders' health. Objective: To determine the effect of toxic gases and metal fumes produced during 3 welding processes on welders' incidence of respiratory symptoms and pulmonary function. Methods: This cross-sectional study was conducted in an Iranian shipbuilding industrial factory in 2018. Using the simple census method, 60 welders were selected as the exposed group. 45 staff members of the administrative unit were also recruited to be served as the control group. Welders' demographic data and respiratory complaints were collected employing a questionnaire. Fumes and gases produced were sampled from the welders' respiratory tract and analyzed by standard methods suggested by the National Institute of Occupational Safety and Health (NIOSH). Pulmonary function test was also performed for each participant. Results: The prevalence of respiratory symptoms in all welders was significantly (p<0.05) higher than the control group. The mean FVC, FEV1 and FEV1/FVC measured in welders involved in all 3 processes were significantly lower than those recorded in the control group. The spirometry pattern in welders involved in flux cored arc welding and shielded metal arc welding was obstructive; that in those involved in gas metal arch welding was mixed (obstructive and restrictive pattern). Conclusion: Exposure to welding fumes and gases was associated with pulmonary function deterioration. Welders involved in gas metal arch welding had a prevalence of pulmonary disorders compared with those involved in gas metal arch welding and flux cored arc welding.
Entornos virtuales de aprendizaje en comunidades de práctica de docentes universitarios del Ecuador
Authors: Arroyo Vera Zoila , Fernández Prieto Santiago , Barreto Zambrano Lenin , Paz Enrique Luis Ernesto
Published: February 2019

El empleo de los entornos virtuales de aprendizaje supone un cambio de paradigma en las formas en las que se realiza el proceso docente universitario. En Ecuador, existen grandes potencialidades para el uso de entornos virtuales de aprendizaje en la universidad; sin embargo, la mayor parte de los docentes desconoce los beneficios de las plataformas y se rechaza su uso. Se plantearon como objetivos del estudio: 1) examinar aspectos teóricos sobre los entornos virtuales de aprendizaje en el contexto universitario e 2) identificar las características de los entornos virtuales de aprendizaje en el Ecuador. Para la obtención de resultados, se plantearon métodos en los niveles teórico y empírico. Se determinaron las características y beneficios de dichos entornos y se analizaron las ventajas que traería su uso intensivo en la comunidad de práctica de docentes universitarios del Ecuador.
Potential yield and efficiency of N and K uptake in tubers of cvs. Capiro and Suprema (Solanum tuberosum Group Andigenum)
Authors: Gómez Manuel Iván , Magnitskiy Stanislav , Rodríguez Luis Ernesto
Published: February 2019

Potato yield depends on the genotype-environment interaction, edaphic nutrient supply, and fertilization rates. The total tuber yield (FWt), dry weight of tubers (DWt), harvest index (HI) and nutrient use efficiency in tubers (NUEt) were evaluated in the Andean region in Colombia at 75, 100, 125, and 150 d after sowing using two cultivars (Capiro, Suprema), three locations with contrasting soils (Subachoque, Facatativa and Choconta) and two levels of fertilization: F0 (unfertilized) and F1 (fertilized). The Humic Dystrudept soils with fertilization (Choconta) presented late tuber filling with increases of 48 and 64% for the DWt in the cvs. Suprema and Capiro, respectively. In Suprema, the highest production potentials were obtained in fertilized soils with low fertility, with increases of 60.9% for the DWt and 75% for the HI. On the other hand, Capiro was better adapted to soils with medium to high fertility, with increases of up to 86.7% for the FWt, as compared to the unfertilized soils. This increase may be related to higher rates of nutrient recovery efficiency (RFt), higher accumulated nutrients per tuber yield (EPt) and a better NUEt because N. Suprema presented a negative EPt and RFt with HI<45% and the lowest NUE of N and K in high fertility soils, which represents a null response to fertilization and possible mechanisms of luxury consumption for the evaluated elements.
ADAM and ADAMTS Proteases in Hepatic Disorders
Authors: Bolik Julia , Tirnitz-Parker Janina E. E. , Schmidt-Arras Dirk
Published: February 2019

Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes. This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology.
Más allá de la productividad
Authors: Mendoza-Guerra José María
Published: February 2019

Como es muy conocido, examinando los dos escalafones más importantes de la competitividad, Colombia se ha ubicado en un período largo de tiempo, en la franja media, de acuerdo con el puesto alcanzado en cada ranking. Además, las tasas de crecimiento del país han dependido más del vaivén de los precios de los commodities que de la orientación de la economía hacia la generación de valor para el mercado. Estos dos factores vienen presentándose en un período largo de tiempo, por lo que se puede decir que el fenómeno de baja competitividad y, por tanto, bajo crecimiento, es un hecho estructural. La sensación que se tiene es que Colombia no ha podido avanzar en la materia.

 Como es obvio, esta situación se vuelve común y la población comienza a preocuparse por lo que está pasando: que somos un país regular desde el punto de vista competitivo. Como respuesta, gente de economía y negocios en el país viene planteando la necesidad de elevar la productividad, haciendo eco de voces que han resaltado esta variable como el elemento central en la economía mundial actual. Pero realmente se debe formular la pregunta: ¿Es la productividad suficiente? Esto es ¿si le apostamos a la elevación de la productividad, se puede superar el problema de la competitividad?
Inteligencia emocional y rendimiento académico en estudiantes de nivel primario en una institución educativa confesional de la selva peruana
Authors: Pinedo Chambi Dámaris , Richard Pérez Sara Esther
Published: February 2019

El objetivo del estudio fue establecer la relación entre inteligencia emocional y rendimiento académico en estudiantes del nivel primario de una institución educativa confesional de la selva peruana. Se trata de un estudio tipo descriptivo correlacional, no experimental de corte trasversal. Para medir la inteligencia emocional se aplicó el Inventario de Inteligencia Emocional de Baron ICE NA, adaptado en Perú por Ugarriza y Pajares. (2003) y para rendimiento académico se tomaron en cuenta las notas de las áreas de Comunicación y Matemática. La población estuvo conformada por 235 estudiantes de tercero a sexto grado de primaria, cuyas edades oscilan entre 8 a 13 años, de ambos sexos. Se encontró que no existe relación significativa entre la inteligencia emocional y el rendimiento académico en el área de comunicación, pero sí hay relación significativa en el área de matemática. En cuanto a las dimensiones se halló que no existe relación significativa entre la inteligencia intrapersonal, adaptabilidad, manejo de estrés y el rendimiento académico en las áreas de comunicación y matemática; sin embargo, sí existe relación de la inteligencia interpersonal y el rendimiento académico en el área de matemática.
ÖĞRETMENLERİN YAPILANDIRMACI YAKLAŞIMA İLİŞKİN ÖZ YETERLİK ALGILARI İLE TUTUMLARI
Authors: ESKİCİ Menekşe , ÖZEN Raşit
Published: February 2019

Bu araştırmanın amacı;
ilköğretim öğretmenlerinin yapılandırmacı yaklaşımı uygulamaya yönelik öz
yeterlik algılarını ve tutumlarını belirlemek ve ilköğretim öğretmenlerinin
yapılandırmacı yaklaşıma ilişkin öz yeterlik algıları ile tutumları arasındaki
ilişkiyi ortaya koymaktır. Ayrıca araştırma ile ilköğretim öğretmenlerinin,
görev yaptıkları yerleşim birimi ile yapılandırmacı yaklaşıma yönelik öz
yeterlik algıları ve tutumları arasındaki ilişki belirlenmeye çalışılmıştır.
Tarama modelindeki bu araştırma 2011-2012 eğitim-öğretim yılında Kırklareli’de
görev yapan 609 gönüllü ilköğretim öğretmeni ile gerçekleştirilmiştir. Verilerin
analizi sırasında Aritmetik Ortalama, Standart Sapma, MANOVA, Tukey Testi,
Korelasyon kullanılmıştır. İlköğretim öğretmenlerin yapılandırmacı yaklaşımı
uygulamaya yönelik öz yeterlik algılarının, görev birimine göre anlamlı düzeyde
değiştiği tespit edilmiştir. İlköğretim öğretmenlerinin yapılandırmacı
yaklaşımı uygulamaya yönelik tutumlarının, görev yapılan birime, göre anlamlı
düzeyde değişmediği, tespit edilmiştir. Ayrıca ilköğretim öğretmenlerin
yapılandırmacı yaklaşıma yönelik öz yeterlik algıları ile tutumları arasında
orta düzeyde, pozitif ve anlamlı bir ilişki olduğu tespit edilmiştir.
İNFORMAL İLETİŞİM KANALLARININ GELİŞİM SÜRECİ VE GRAFİK TASARIM
Authors: YASA Serap
Published: February 2019

Kitle iletişim
araçlarının hızla yayılması ve her gün milyonlarca mesaj üretilerek, çok geniş
bir hedef kitleye yönelinmesi, hedeflenen bu kitleye en kolay, en hızlı, en
başarılı ulaşımı sağlayacak pek çok  iş
alanının doğmasına yol açmıştır. Ancak, hedef durumundaki bireyin, çok sayıda
kanal aracılığıyla sürekli mesaj bombardımanına tutulması sonucu duyarsız hale
gelmesi, hem ticari boyutta hem de insan bilimciler tarafından tehlikeli
bulunmaya başlanmıştır. Ticari şirketler insanı nasıl yeniden kazanır satışları
arttırırız kaygısı ile toplum bilimciler değişen rol ve statü karmaşası içinde
insanın yeni yerini saptayabilmek amacı ile çok boyutlu araştırmalara
girmişlerdir. İnformal iletişim gibi yöntemler çağın gereksinimleri
doğrultusunda ortaya çıkmıştır. Pazarlanan “ürün” sadece ticari meta olmayıp
düşünce, davranış şekli vb. gibi zihinsel boyutlu da olabilmektedir. Tüm bu
ürünlerin tanıtımında kullanılan medyanın seçimi, pazarlamadaki etkin
yöntemler, insanların algılamalarına etki eden psikolojik, fizyolojik faktörlerin
incelenmesi bu araştırmanın temel amacını oluşturmaktadır.  Araştırmanın yöntemi belgesel
tarama yöntemidir. İnsan ve iletişim çeşitleri ile pazarlama stratejileri
saptanmış ve sınıflandırılmıştır. Böylece yönlendirme ve direk pazarlama
yöntemlerinde kullanılan grafik tasarım ürünlerinin yeri üzerinde durulmuş ve
bu ürünlerin başarıları ile ulaşılmaya çalışılan hedef kitlenin bağlantısı
üzerinde durulmuştur.
UNDERGRADUATE ELT STUDENTS’ PERSPECTIVE ON A COURSE-BASED SCIENTIFIC RESEARCH CONVENTION
Authors: KORKUT Perihan
Published: February 2019

Although teacher education has a research methods component to prepare the teachers of the future to engage in research, it rarely provides teacher candidates opportunities for participating in research conventions. One of the scarce attempts to do so was a course-based scientific research convention held in the English Language Teaching department of a university in Turkey. The participants were third-year students who presented their research in one of the forms of oral presentation, poster presentation or workshop during the one-day event. In this study, the students’ expectations, experiences, and perceptions pertaining to the convention were sought. Data were collected through open-ended questionnaires at the beginning of the term and after the convention. In addition, volunteering students kept reflection journals during the process. It was found that the students perceived the event as useful in terms of learning scientific research procedures and the researched subject. The areas which were perceived as the most difficult were finding the right resources and following the program which they found too tight and tiring. According to the findings, participating in this event had a positive effect on their future orientations for most of the students.
OTİZMLİ ÖĞRENCİLERE BİR EĞİTSEL OYUNLA “İÇ ORGANLARINI TANIYABİLME” KONUSUNUN ÖĞRETİMİ
Authors: ASLAN Kübra , KARAMUSTAFAOĞLU Orhan , KURT Murat
Published: February 2019

Bu
çalışmada, Otistik Çocuklar İçin Uygulama Merkezi II. Kademe eğitim programında
yer alan “İç Organlarını Tanıyabilme” konusunun öğretimine yönelik eğitsel bir
oyun tasarlanmıştır. Tasarlanan oyunla otizmli öğrencilerin derste aktif olması
ve soyut kavramların bulunduğu “iç organlarını tanıyabilme” konusunu eğlenerek
öğrenmesi amaçlanmıştır. Çalışmada olgubilim araştırma yöntemi kullanılmıştır. Bu
çalışmada amaçlı örnekleme yöntemlerinden ölçüt örnekleme kullanılmıştır.
Tasarlan oyunun uygulanabilirliği ile ilgili Otistik Çocuklar Eğitim
Merkezi’nde görev yapan üç özel eğitim öğretmeni ile görüşülmüş ve oyun, yaşları
12 ve 14 olan otizm tanısı konulmuş iki erkek öğrenciye uygulanmıştır.
Çalışmada veri toplama aracı olarak yarı yapılandırılmış mülakatlar ve informal
gözlemler kullanılmıştır. Çalışmanın bulgularına dayanarak tasarlanan oyunun
“iç organlarını tanıyabilme” konusunun öğretiminde uygulanabilir bir eğitsel oyun olduğu sonucuna varılmış, tasarlanan
oyuna ilişkin bazı önerilerde bulunulmuştur.
UZAMSAL İLİŞKİLER TESTİNİN GELİŞTİRİLMESİ: GEÇERLİK VE GÜVENİRLİK ÇALIŞMALARI
Authors: DOKUMACI SÜTÇÜ Neşe , ORAL Behçet
Published: February 2019

Bu araştırmada, ortaokul
öğrencilerinin uzamsal ilişkiler becerisi üzerine çoktan seçmeli bir test
geliştirmek amaçlanmıştır. Testin geliştirilme aşamasında, kapsam ve görünüş
geçerliği için uzman görüşü alındıktan sonra testten altı madde çıkarılmış ve
24 maddelik test geçerlik ve güvenirlik çalışmaları için 303 yedinci sınıf
öğrencisine uygulanmıştır. Testin faktör yapılarını belirlemek amacıyla
maddeler arası tetrakorik korelasyon matrisine dayalı olarak açımlayıcı faktör
analizi yapılmış, iki madde testten çıkarılarak iki faktörlü bir yapı elde
edilmiştir. Daha sonra testin iki faktörlü yapısının bir model olarak
doğrulanıp doğrulanmadığı belirlemek için asimptotik kovaryans matrisi ile
ağırlıklı en küçük kareler yönteminden yararlanılarak doğrulayıcı faktör
analizi yapılmıştır. Testteki bir maddenin faktör yükü .30’dan küçük ve hata
varyansı .90’dan büyük olduğu için madde testten çıkarılmış ve iki faktörlü
yapının yeterli uyum indekslerine sahip olduğu görülmüştür. Kalan
21 madde için madde analizi
yapılmış; testin farklı güçlük düzeylerine ve
yüksek ayırt ediciliğe sahip maddelerden oluşan, orta güçlükte ve ayırt ediciliği yüksek
bir test olduğu ortaya çıkmıştır. Birinci faktör için KR-20
iç tutarlılık katsayısı .79, ikinci faktör için .73 ve testin geneli için .74
olarak hesaplanmıştır.
Assessment of the Efficient Strategies for Applying Antitumor Viral Vaccine Therapy Based On Mathematical Modeling
Authors: Babushkina N.A. , Kuzina E.A. , Loos A.A. , Belyaeva E.V.
Published: February 2019

The paper presents the mathematical description of the two stages of tumor cells’ death as a result of immune response after antitumor viral vaccine introduction.
This mathematical description is presented by the system of nonlinear equations implemented in the MatLab-Simulink system. As a result of the computing experiment,
two strategies for effective application of the antitumor viral vaccine were identified. The first strategy leads to complete elimination of the tumor cells after a
single-shot administration of the vaccine. The second strategy makes it possible to stabilize tumor size through the recurrent introductions of the vaccine.
Using the mathematical model of antitumor therapy, appropriate dosages were identified based on the number of tumor cells that die at the two stages of immune response.
Dynamics of tumor growth for the two strategies of the viral vaccine application was forecasted based on the mathematical model of antitumor therapy with discontinuous
trajectories of tumor growth. The computing experiments made it possible to identify initial tumor size at the start of the therapy and the dosages that allow complete elimination
of the tumor cells after the single-shot introduction. For the second strategy, dosages and intervals between recurrent vaccine introductions required to stabilize tumor size at
the initial level were also identified. The proposed approach to exploring the effectiveness of vaccine therapy may be applied to different types of experimental tumors and antitumor vaccines.