bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Peningkatan Hasil Belajar Biologi Dengan Menerapkan Model Pembelajaran Discovery Learning Terpadu
Authors: Prasetyo Faisal Imam , Lenggono Budi
Published: July 2024

The purpose of this study was to determine the improvement of learning outcomes of students in class X MIPA 1 in Integrated Islamic High School of Nurhidayah Sukoharjo by applying the Discovery Learning “TERPADU” model in online learning. This research is a classroom action research model of Kemmis and Taggart which consists of four stages in each action, namely planning, implementation and observation, evaluation, and reflection. The research was conducted in two cycles of action. The subjects of this research were students of class X MIPA 1 with a total of 34 students. This research instrument is in the form of tests and non-tests. The results of this study indicate the achievement of student learning outcomes that have increased from pre-action to cycle I to cycle II, namely: (1) the student's average score of 66.68 (pre-action) increased to 82.72 (cycle I) then increased again to 89.11 (cycle II), (2) the percentage of classical completeness of 51.67% (pre-action) increased to 82.33% (cycle I) then increased again to 100% (cycle II), (3) N-gain of 0.31 in the “medium” category (cycle I) increased to 0.58 or stayed in the “medium” category (cycle II). Based on these results, it can be concluded that the application of the Discovery Learning “TERPADU” model can improve Biology learning outcomes. Based on this study, the researcher provides suggestions: (1) this Discovery Learning “TERPADU” model also needs to be tested in other class action research either conducted in online mode or offline mode (in the classroom) and (2) this research needs to be developed by using information technology and computer-based learning media in offline mode learning.
Implementasi Outdoor Learning Model Numbered Head Together dalam Meningkatkan Materi Keliling dan Luas Lingkaran
Authors: Wahyu Lilik , Kunti Dian Ayu Afiani  , Deni Adi Putra
Published: July 2024

This study aims to describe the implementation of Outdoor Learning using the NumberedHead Together (NHT) model, which can enhance students’ mathematics learningoutcomes on circumference and area of a circle, and to describe the results of students inthe learning process. The research is a Classroom Action Research (CAR) that carriedout in two cycles. Each cycle consists of planning, implementation, observation, andreflection. The research subjects were fourth grade students at SD Muhammadiyah 16Surabaya. The data collection techniques were observation and written tests, while the data analysis techniques involved the results of observation and simple statistics. Thefindings showed that in Cycle I, students’ achievement outcomes reached 62% with anaverage class of 77.75, and increased in Cycle II that reached 85% with an average classof 81.46. Based on the results of the completion and average class scores obtained, it can be concluded that the implementation of Outdoor Learning with the Numbered Head Together (NHT) model is said to be successful if the completion and average class scores increase significantly and make students become more active in discussing with each other to solve problems and understand the material.
Is “Something Else” Needed Before Establishing a Family Council? The Role of Communication in Business Familiesole of communication within business families
Authors: Rodríguez-García María , González-Cruz Tomás
Published: July 2024

Establishing a family council can be beneficial for business families. However, determining the optimal circumstances to do so can be challenging. While some experts argue that a family council always provides long-term benefits, recent research on family councils suggests that there are certain prerequisites for successful family council implementation. This paper explores the nature of these prerequisites by examining communication dynamics within business families. Olson’s Circumplex Model is transferred from family therapy to the context of the family council by applying Habermas’s criteria for an ideal speech situation. Within this framework, a communication continuum on which to position business families is developed. This continuum is then applied to three Spanish business families. The findings suggest that a family council is functional only when minimum communication standards are met within the business family. Otherwise, the family council may have a minimal or even a negative impact. Families with an active family council should prioritise its use as a space for dialogue to enhance the business family’s functionality before tackling any other tasks or functions.
Analysis of the food allergen profile in meat from chickens fed five mixed feeds
Authors: Półtorak Andrzej , Żbik Klara , Kołodziejczak Klaudia , Michalczuk Monika , Onopiuk Anna
Published: June 2024

Food allergies are a severe issue in developed countries. Allergenic proteins may be present in ready food products due to their natural occurrence in raw materials or cross-contamination during production. Although raw meat was previously thought to be free of potentially allergenic compounds, recent studies have proved the presence of specific allergenic proteins in meat from slaughter animals and poultry. This study aimed to assess the impact of five distinct feed mixtures on the presence of allergenic proteins in broiler chicken meat, as well as on the quality and technological parameters of poultry meat. The animals were divided into five groups, with four being fed specially formulated compound feeds. The control group consisted of chickens fed commercial feed. ELISA tests were used to measure and analyse the content of food allergens in feed and chicken meat. Additionally, a baseline meat composition analysis was performed using near-infrared NIR spectroscopy. The study demonstrates that the composition of feed impacts the presence of allergenic proteins in broiler chicken meat. The results of the tests revealed the presence of allergenic proteins in the breast muscle that were not identified in the feed, specifically egg and milk proteins.
The Road Toward Sustainability in the Romanian Fast Fashion Organisations
Authors: Pătruț Petra
Published: June 2024

The continuous level of consumption in the fast fashion industry has a concerning effect and needs to be addressed through a strategic approach, as it has a considerable environmental, social, and economic impact. The study contributes to a better understanding of the barriers hindering the transition toward a more sustainable future in the fast fashion industry through qualitative research. We conducted the qualitative research using the Grounded Theory, which allows an evaluation from different and multiple perspectives, resulting in a more exhaustive and justified result. Our approach was exploratory, and the results will be tested in future studies. The purpose of the paper was to map the road to sustainable fashion by understanding the obstacles/barriers, and solutions/drivers for sustainable development. The sustainability fast fashion organizational barriers were identified in the international literature through a structured literature review and further tested for the Romanian market through interviews. After the NVivo Analysis, the identified barriers referenced the most to least, from a Romanian organisational dimensions perspective were financial barriers, insufficient management engagement, lack of Romanian governmental support and infrastructure, eco-friendly packaging, and stakeholder and supplier barriers. The most mentioned driver dimension from an organisational point of view was the existence of a financial reward system for stakeholders, funding programs from the Government and EU, the implementation of mandatory regulations, and the possibility of creating an infrastructure.
A New Path to Cultivate Talents: Innovative Teaching Methods for Digital Film, Television and Animation Majors in Chinese Universities
Authors: Dong Jun
Published: June 2024

The study aims to investigate the reform and innovation of teaching methodology for digital cinema and television animation majors. The rapid growth of the animation industry and the need for skilled professionals, along with the drawbacks of traditional teaching methods, emphasize the need for reform in the way animation majors are taught. This text then provides a detailed explanation of the basic principles, characteristics, and prospective benefits of the university-industry cooperation model of talent cultivation in the education of animation majors. The discussion on the education of animation students centers on the improvement of teaching materials and methods through the university-industry cooperation talent cultivation model. Emphasis is placed on developing students’ practical skills. Through the analysis and evaluation of innovation strategies, recommendations for improvement and optimization are proposed. The results of the study show that the application of the university-industry cooperation talent cultivation mode in the teaching of animation majors is of great significance and promise. This approach can effectively develop students’ comprehensive abilities and practical skills. This study serves as a valuable resource for animation teachers, encourages improvement and creativity in teaching animation students, and provides insights into potential future research areas.
Media Representations and Practices of Discrimination against Immigrants from an Intersectional Perspective
Authors: Mandelc Damjan
Published: June 2024

The article addresses the phenomenon of mass migration through an intersectional analysis, highlighting the interaction of discriminatory practices and exploring common exclusion mechanisms in the case of two minority groups: Muslim women and migrants/refugees. The starting point of the analysis is the media discourse on two legal documents addressing the ban of Muslim women’s headgear and the problem of illegal migration (the Marrakesh Declaration). The results of the research are applied to a broader reflection on the causes and consequences of discriminatory policies on minority and immigrant communities.
Visualising War / Peace Photographs: A Comparative Analysis of Selected Asian News Sites’ Coverage of the 2022 Russian-Ukrainian Conflict
Authors: Elareshi Mokhtar , Ziani Abdulkrim , Alsridi Hatem , Tahat Khalaf
Published: June 2024

This study analyses the visual coverage of the 2022 Russian-Ukrainian conflict on Asian news sites, utilising the frameworks of war and peace journalism. Conducting a content analysis of 397 images from seven leading Asian news sites, we contribute to the literature on visual coverage, particularly from online platforms. Our analysis identifies the predominant visual narratives employed by these news sites and offers insights into variations in coverage intensity, regional and ethnic focuses, portrayal of age groups, and depiction of harm. The study extends the understanding of framing theory by analysing visual frames, providing valuable implications for future visual studies and contributing to a deeper understanding of conflict portrayal in online news media.
Architectural Heritage Buildings and Tourism Sustainability in Karangasem Bali
Authors: Putra I Dewa Gede Agung Diasana , Adhika I Made , Aritama Anak Agung Ngurah , Putra I Dewa Gede
Published: July 2024

Objective: This study aims to explore and understand the interrelationships between cultural tourism and architectural heritage sites through tourist image and perception. These interrelationships must balance community needs, available resources, executive efforts and regional planning while protecting the environment.
 
Theoretical Framework: Historic buildings are considered important elements in cultural heritage, and architecture is further considered to be one of the most important aspects that attract tourists. As a significant part of cultural heritage and tourism resources, architectural heritage is the most important commemorative, secondary architectural buildings and its natural and artificial environments in ancient areas and characteristic villages.
 
Method: This study's method is based on mixed-method research, which is known as triangulation. This approach entailed gathering initial data, conducting interviews and surveys, and creating house maps. Traditional architectural documentation tools, such as drawings, plans, sections, elevations, and photographs, are required in all three process stages.
 
Results and Discussion: Bali has a diversity of forms and varieties of traditional architecture. East Bali, part of the Karangasem kingdom called puri during the Mindle era of Bali, has preserved several unique architectural masterpieces. In this context, architectural heritage is critical in increasing property values. Preserving architectural heritage is considered environmentally friendly for cultural tourism.
 
Research Implications: This study explores to what extent heritage architecture can be utilized as cultural heritage ideally and efficiently. This can be achieved by building sustainable restoration of archaeological and heritage sites to achieve sustainable heritage tourism.
 
Originality/Value: This research utilizes experiments in countries with cultural heritage to obtain lessons, values and concepts that contribute to achieving an efficient program for sustainable tourism development based on the preservation of heritage areas.
Specific features of arterial stiffness and endothelial vasomotor dysfunction in patients with joint hypermobility syndrome
Authors: Karpovich Yu. L. , Pronko T. P.
Published: July 2024

Introduction. Joint hypermobility syndrome (JHS) is characterized by a multisystem lesion of organs, including the cardiovascular system, which determines the presence of cardiovascular risks in this pathology. Aim. Studying of arterial stiffness and endothelial dysfunction parameters in patients with JHS. Material and methods. Study population included 105 adults with JHS (90 women and 15 men) and 57 healthy controls (49 women and 8 men) aged 20 to 28 years (mean age 22 [21; 23] years). All persons underwent a general clinical examination; examination of endothelial vasomotor function (EVF) and pulse wave velocity at the carotid-radial segment (PWVcr) by rheography (IMPECARD-M, Belarus); investigation of arterial stiffness parameters: cardio-ankle vascular index (CAVI), cardio-ankle pulse wave velocity (PWVha), ankle-brachial index (ABI), augmentation index (AI) by sphygmography (VaSeraVS-1500N Fukuda Denshi, Japan); determination of T786C polymorphism of the eNOS gene by polymerase chain reaction (Litech, Russia), determination of endothelin-1 and transforming growth factor beta-1 (TGF-β1) levels by enzyme immunoassay (Fine Test, Wuhan Fine Biotech Co., China). Results. According to the main clinical and laboratory indicators, the groups were matched. In patients with JHS, the values of PWV at the carotid-radial and cardio-ankle segments were higher, in other parameters (EVF, CAVI, ABI, AI) the groups were matched. In the group with JHS, pathological values of EVF, PWVcr, CAVI, AI were more often determined. Among patients with JHS, an excess of vascular age over the passport age is detected 8.6 times more often (95% CI from 1.103 to 67.321). These changes are not associated with mutations of the eNOS T786C gene and changes in endothelin-1 and TGF-β1 concentrations. Conclusion. These data indicate the importance of further study of the mechanisms of early vascular changes in the arteries in JHS, in order to develop optimal methods of therapy and improve the cardiovascular prognosis of patients with this pathology
Predicting the development of delayed cerebral ischemia in patients with ruptured arterial aneurysms
Authors: Nechipurenko N. I. , Stepanova Yu. I. , Pashkovskaya I. D. , Sidorovich R. R.
Published: July 2024

Introduction. Vasospasm and delayed cerebral ischemia (DCI), which develop after rupture of cerebral arterial aneurysms and their surgical treatment, are serious complications that worsen the clinical outcome of the disease. The ability to predict the risk of developing these complications is an urgent task allowing to reduce neurological deficits and improve the quality of the patients’ life after aneurysm rupture. Aim – to develop a prognostic model for the development of DCI in patients with ruptured cerebral arterial aneurysms based on the study of a complex of clinical manifestations and a number of laboratory parameters. Material and methods. We examined 91 patients with ruptured arterial aneurysms and the development of subarachnoid hemorrhage in the acute period, identifying the main group with the development of DCI (n=67) and the comparison group without DCI (n=24) in the pre- and postoperative periods. Clinical neurological and neuroimaging studies have been carried out. We studied indicators of blood oxygen transport function, platelet aggregation, coagulogram, concentration of nitrates/nitrites (NOx), angiotensin-converting enzyme (ACE) in venous blood in the pre- and postoperative periods. Results. Based on the logistic regression equation, we determined that predictors influencing the probability of DCI development after aneurysm rupture and clipping include a score on the Glasgow Coma Scale (p=0.001), the p50 value is the partial pressure of oxygen in the blood at which hemoglobin is oxygen saturated by 50% (p=0.001), ACE concentration (p=0.013), NOx/ACE index (p=0.001) and the degree of platelet aggregation according to Traptest (p=0.005). The threshold value of the result of the logistic regression equation was 0.58 with a diagnostic sensitivity of 85.4% and specificity of 69.3%, the area under the ROC of the AUC curve was 0.88±0.015 (p<0.001), which indicates the high quality of the constructed model. Conclusion. The developed predictive model of the probability of DCI development in patients with ruptured arterial cerebral aneurysms with a diagnostic efficiency of 88% allows timely identifying patients for whom it is advisable to begin neuroprotective therapy before surgical treatment.
Peculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsia
Authors: Klycheva M. M. , Panova I. A. , Nazarov S. B. , Kuzmenko G. N. , Sadov R. I. , Popova I. G.
Published: July 2024

Introduction. In preeclampsia (PE), the hemostasis system, including the platelet component, changes significantly. The purpose of the work was to identify the peculiarities of the morpho-functional characteristics of platelets in women with early and late PE. Material and methods. The main group consisted of 26 women with early PE and 46 women with late PE. The control group consisted of women with normal pregnancies without hypertensive disorders, of whom 17 were at a gestational age of 260–336 weeks and 42 were at a gestational age of 340–394 weeks. The ADVIA 2120i hematology analyzer was used to evaluate platelet concentration (PLT), platelet distribution width (PDW), mean platelet volume (MPV), concentration of large platelets (Large PLT), percentage of large platelets from the total number of platelets (%LP), mean platelet component concentration (MPC), mean dry platelet mass (MPM). Results. Women with early PE have increased PDW, MPV, LargePlt, %LP and MPM indices compared to women with normal pregnancies up to 34 weeks. Female patients with late PE had lower PLT and higher PDW, %LP, MPC, MPM compared to women with normal pregnancies after 34 weeks. In late PE, PLT is reduced and PDW, %LP and MPM are increased compared to early PE. Conclusion. The detected changes in platelet indices in women with PE, regardless of the period of its onset, indirectly indicate increased thrombopoiesis and high functional activity of young platelets. However, the mechanisms that increase platelet activation in early and late preeclampsia differ.
Healing from Intersectional White Supremacy Culture and Ableism:
Authors: Chordiya Rashmi , Protonentis Adana
Published: July 2024

In this exploratory article, we build on the existing literature to identify and discuss the patterns of white supremacy culture (WSC) that are pervasive in our organizational spaces. We argue that because WSC, racism, and ableism are deeply intersectional forms of oppression, our social equity approaches must include a disability justice (DJ) lens, which centers the leadership of multiply marginalized disabled, queer, trans*, Black, Indigenous, and negatively racialized People of Color (QTBIPOC). Using an embodied approach, we invite our readers into a deeper reflection and critical analysis of the intersectional manifestations of white supremacy culture and ableism in organizational spaces. We explore the ways in which the 10 principles of disability justice could serve in creating supportive countercultural norms, values, and behavioral practices needed to create the conditions for healing from white supremacy culture.
Gender Equity in Public Affairs Pedagogy:
Authors: Elias Nicole M. , D'Agostino Maria J. , Diez Vanessa , Krause Erik
Published: July 2024

Gender is an important component of Diversity, Equity, and Inclusion (DEI) pedagogy in public affairs, yet gender remains largely absent from public affairs education in three central ways: how courses are structured, the content of courses, and the practice of pedagogy. This article explains the value and need for gender equitable pedagogy in public affairs curricula. We conduct a descriptive analysis of scholarship and best practices from leading think tanks and public advocacy research organizations. Ultimately, this work provides recommendations to strengthen gender equity pedagogy both inside the classroom and in public sector workplaces.
Truth, Racial Healing, And Transformation:
Authors: Brown Heath
Published: July 2024

The public policy process in the United States has strong status quo biases that frustrate efforts to adopt policies focused on racial justice and social equity. On occasion, a policy window opens and the chance for real change increases greatly. This article is a case study focused on advocacy for a Truth, Racial Healing, and Transformation (TRHT) Commission during an open policy window that occurred in 2020 related to brutal police violence (readers should know in advance that traumatic events covered in this article include descriptions of racial violence). The findings are drawn primarily from original interviews with advocates for the Commission, providing an outsider’s perspective on this political process.
How Government-Backed Registered Retirement Savings Plans Impact Canadians’ Tax-Free Savings Account:
Authors: Biaou Gino , Charbonneau Étienne
Published: July 2024

Personal savings can help cushion financial difficulties and reduce the need to apply for government assistance. This study examined who benefits the most and the least from the government-supported Registered Retirement Savings Plan (RRSP) and Tax-Free Savings Account (TFSA). The compound theory of social equity was used to analyze data from the 2019 Canadian Survey of Financial Security. The results suggest that there are disparities in contributions to TFSA and RRSP based on the level of education and gender of single parents. Our analysis using correlation, OLS, and quantile regressions found that there are statistically significant but relatively small differences in contributions for less educated individuals and single-parent families led by women. These findings suggest that governments could focus on financial education, improve financial inclusion policies, and review rules on TFSA and RRSP contribution limits, which could pose a cognitive administrative burden for vulnerable households.
INTERNATIONAL MEDICAL FORUM “UKRAINIAN AND GLOBAL MEDICINE: BASICS, REALITY, AND STRATEGIC PROSPECTS”
Authors: Nesterovska Liliia
Published: June 2024

From December 13 to 15, 2023, the International Medical Forum (IMF) “Ukrainian and Global Medicine: Basics, Reality, and Strategic Prospects” was held successfully. Within the framework of this forum, the 12th Christmas Readings on Immunology and Allergology were held. The event was dedicated to the 150th anniversary of the Shevchenko Scientific Society (SSS), the 125th anniversary of the Medical Commission of the SSS, and the 25th anniversary of the Department and Center of Clinical Immunology and Allergology. Event hosts were the Medical Commission of the Shevchenko Scientific Society and Danylo Halytsky Lviv National Medical University. Despite difficult times for Ukraine, the event did not lose its leadership positions in terms of the number of speeches and the diversity of the agenda, and the vast geography of speakers and specialist attendees distinguished it. More than 400 speakers, about 1,000 listeners, and more than 1,200 online participants participated in the event. During three days, international experts from the USA, Canada, UK, Italy, Spain, Denmark, Slovakia, Sweden, Germany, Austria, and Poland, and leading scientists and experts for Ukraine delivered more than 300 speeches.
LOCAL COMPLICATIONS OF RESIDUAL UPPER AND LOWER LIMBS IN COMBATANTS
Authors: Trutyak Ihor , Knyhynytskyi Volodymyr , Malytskyi Vasyl , Bohdan Ivan , Ivashchenko Vitaliy , Trunkvalter Vasyl
Published: June 2024

Introduction. Contemporary combat limb injury is characterized by massive soft tissues and bone structures, which often makes it impossible to save the injured extremity and need for its amputation. However, a number of amputees have pain syndrome in the residual limb and cannot use prostheses.
Objective. To analyze local complications, causes of residual limb pain syndrome, and methods of their treatment.
Methods. We observed 285 combatants with residual limb pain syndrome after its combat injury, of which 151 (53%) had neuromas and 108 (38%) had heterotopic ossification and osteophytes. All individuals were male. The average age was 36.13±8.64 years. The intensity of the pain syndrome according to the Defense and Veterans Pain Rating Scale (DVPRS) ranged from 4 to 10 points.
Results. Treatment of persistent pain in the stump with analgesics was not effective. Denervation of neuromas using alcohol injections, performed in 69 (24.2%) patients, was effective in pain syndrome intensity up to 6 points on the DVPRS scale. Neuroma resection was effective in 77% of patients, but sensitization persisted in 23%. Recurrent pain syndrome with lower intensity was observed in 30% after neuroma resection, nerve stump compression with cautery and alcohol blockade. Addition these procedures with the nerve stump suture, reduced neuroma recurrences by up to 10%. The best results of surgical treatment of neuromas with pain syndrome of 6 points and more on the DVPRS scale were obtained after their resection and the use of regenerative peripheral nerve interface (RPNI) in 25 patients. These patients had no recurrence of pain syndrome within 2 months after surgery. Heterotopic ossification most often occurred in patients with mine-explosive injuries in the thigh stumps 2-6 months after limb amputation and recurrence after simple resection of osteophytes. After performing myodesis in 18 patients there was no recurrence of heterotopic ossification within a year of observation.
Conclusions. Neuromas of peripheral nerves and heterotopic ossification are the main causes of pain syndrome in late period after amputation in combatants with residual limbs. The most effective methods of surgical treatment of neuromas in residual limbs is neuroma resection and regenerative peripheral nerve interface. Myodesis prevents the formation of heterotopic ossification.
IMPLEMENTATION OF MOLECULAR PROFILING IN THE DIAGNOSIS AND TREATMENT PLANNING OF PATIENTS WITH ADVANCED OVARIAN CANCER
Authors: Hrytsay Iryna , Mazur Yulia , Ferneza Severyn , Sulaieva Oksana , Volodko Natalia
Published: June 2024

Introduction. Early diagnosis and personalized treatment of patients with malignant ovarian tumors based on molecular changes in the tumor of a specific patient is a priority research area in gynecological oncology. However, the clinical informativeness of certain genetic signatures remains unclear. Molecular profiling based on the next-generation sequencing (NGS) method, which allows multigenomic research of ovarian tumors, is not widely used among clinicians in routine clinical practice in Ukraine.
The aim of this study was to evaluate the informativeness of molecular genetic testing using a panel that detects damage to genes of signaling pathways and the homologous recombination system (HRR) for the final diagnosis and determination of the treatment plan for patients with ovarian cancer (OC).
Methods and materials. 30 patients with OC at stages III-IV  undergoing inpatient treatment at the Lviv Regional Oncology Treatment and Diagnostic Center (LROTDC) during 2019–2023 were examined. The presence of germinal and somatic mutations in 32 genes was investigated using the NGS method, including genes of the HRR system, genes of signaling pathways (BRAF, ERBB2, KRAS, NRAS, РІКЗСА) and the ТР53 gene.
Results. Mutational changes were identified in the tumors of 23 (76.7%) examined patients and in the peripheral blood of 2 (6.7%) patients. Out of 25 cases, DNA repair deficiency by homologous recombination (HRD status) was detected in 14 samples (56%), distributed by tumor morphotype as follows: high-grade serous carcinoma (HGSC) – 9 samples (64.3%), endometrial cancer – 3 samples ( 21.4%) and clear cell carcinoma – 2 samples (14.3%). TP53 mutation was detected in 10 cases (40%), of which seven patients had HGSC (70%). The presence of a KRAS mutation was found in 3 patients (12%) with the morphology of endometrial cancer (2 cases, 66.7%) and HGSC (1 case, 33.3%). A relatively rare AR mutation was also detected in one patient (4%).
HRD status correlated with high sensitivity to platinum-based chemotherapy (85.7% – chemosensitive, 14.3% – chemoresistant). Conversely, the presence of KRAS mutation made it possible to attribute the patient to another morphogenetic type, namely, low-grade serous ovarian cancer, and to apply adjuvant hormone therapy.
Conclusions: Molecular genetic profiling allows for clarifying the morphogenetic type of ovarian cancer and adjusting the patient’s treatment strategy, considering that it is advisable to carry it out at the stages of primary diagnosis of common OC forms.
MODERN VIEWS ON THE DIAGNOSIS AND TREATMENT OF HEREDITARY ANGIOEDEMA: THE IMPORTANCE OF TIMELY DIAGNOSIS AND FURTHER MANAGEMENT OF THE PATIENT
Authors: Lishchuk-Yakymovych Khrystyna , Cherniuk Nataliia , Derkach Marianna , Obtulowicz Krystyna
Published: June 2024

The review focused on managing of patients with hereditary angioedema by administering C1-INH concentrate therapy. Hereditary angioedema is an orphan disorder characterized by recurrent episodes of angioedema, usually localized to the skin/subcutaneous tissue or mucous membranes of the upper respiratory tract and gastrointestinal tract and does not respond to usual treatment with antihistamines, corticosteroids, or adrenaline. Suspicion of HAE І or HAE II should be the basis for requesting laboratory tests to confirm the diagnosis. Determination of the function of C1-INH, C1-INH protein and C4 in serum/plasma is used to diagnose HAE І or HAE II. Own clinical case of management of the patients with HAE was proposed. Typical complex therapy includes a number of measures to avoid triggers of exacerbations and the development of a clear drug treatment plan with the patient (treatment of the acute condition, short-term (pre-procedural) and long-term prophylaxis). The importance of a multidisciplinary approach in the management of the patients with HAE is an important step towards timely verification of this rare/orphan disease.
Aproximación a la interpretación en el Estado constitucional de derechos
Authors: Arcila Rueda Jaime León
Published: July 2024

Este es un primer artículo en el que se resumen los planteamientos realizados en el marco de una investigación sobre el problema de la interpretación en el contexto del Estado constitucional de derecho. De ahí que, en un principio y bajo la guía teórica de Guastini, se reflexione sobre el por qué debemos entender que el ordenamiento jurídico colombiano se ha “constitucionalizado”, considerando siempre como referente la compleja realidad del país. Lo anterior nos conduce a un segundo momento: la introducción al complejo problema que ha ocasionado este fenómeno en torno a la interpretación constitucional en nuestro contexto; por ello el objetivo general de la investigación es explicar la relación que se da entre los métodos de interpretación de reglas y principios en la tarea judicial del juez constitucional colombiano. Al final y con el propósito de avanzar en la conexión teórica y práctica que se establece entre los métodos de interpretación del precedente judicial y el examen de proporcionalidad, se relacionan las principales ideas y los autores involucrados en la reflexión de estos métodos de interpretación en el Estado constitucional de derecho.
¿Es la formalización laboral la ruta hacia el trabajo decente en Colombia?
Authors: Castro Guiza Omar Ernesto , Lozano Martínez Diana del Rocío , Rodríguez Perdomo Darío
Published: July 2024

La presente investigación analiza exhaustivamente el concepto de trabajo informal, tomando las nociones internacionales y las colombianas con el ánimo de explicar, desde un punto de vista jurídico, las implicaciones y afectaciones a los derechos de los trabajadores(as) que realizan actividades laborales informales. Igualmente, con una metodología explicativa y propositiva, el texto expone por qué la formalización laboral parece ser la ruta más próspera hacia el trabajo decente para los trabajadores(as) informales en Colombia, y cuáles deben las estrategias a seguir para avanzar en el tema.
Acute appendicitis in an adolescent with situs inversus totalis: a case report
Authors: Rainer Júlia , Correa Carolina , Garani Sarah , Silva Cecília , Laviola Camilla , Lira Andréa
Published: July 2024

Appendicitis is the most common surgical emergency in pediatrics, being present in 1% to 8% of children with acute abdominal pain. The classical clinical presentation is characterized by the presence of acute migrating abdominal pain in the right iliac fossa. However, in patients with situs inversus totalis, the pain manifests in the left iliac fossa, which may delay the diagnosis and predispose to the development of complications. Thus, the aim of this study is to report a case of appendicitis in an adolescent with situs inversus totalis. METHODS: This study is case report of appendicitis in an adolescent with situs inversus totalis. The research was submitted to the Ethics in Human Research Committee and approved under CAAE number 53591321.0.0000.5237. RESULTS: The incidence of appendicitis in patients with situs inversus totalis is 0.016% to 0.024%. Due to the atypical clinical presentation in these patients, there is a tendency to delay the diagnosis of appendicitis, especially when the situs inversus totalis was not previously identified. Thus, there is a greater risk of developing severe complications such as intestinal perforation and sepsis, which considerably increases morbidity and mortality. CONCLUSIONS: We emphasize the importance of listing appendicitis as a possible diagnosis in patients with acute abdominal pain in the left iliac fossa because of the possibility of situs inversus totalis.
Micronewton Cold Gas Thruster Based on Silicon-Etched Two-Dimensional Nozzles
Authors: Hu Shao Gang , Zhang Hao Yuan , Zhou Wu , Xu Hao , Li Qing , Li Zhu , Yang Shan Qing , Liu Jian Ping
Published: July 2024

The micronewton thruster is one of the essential technologies for providing an ultrastable satellite platform for scientific experiments in space. Particularly, space gravitational wave detection requires a microthruster with continuously adjustable thrust, high resolution, low noise, and fast response. To meet these requirements, we designed a two-dimensional (2D) nozzle and manufactured it using micro-electro-mechanical systems (MEMS). Compared to the nozzles machined with conventional methods, the nozzles etched by the MEMS can easily reach a micron size and form arrays to create mutual backups and also provide a way to widen the thrust range by switching the number of openings. Based on a single 2D nozzle, a cold gas microthruster prototype is constructed with nitrogen gas as the propellant. The thrust of the prototype is tested by a pendulum, the range can span [Formula: see text], the thrust resolution is better than [Formula: see text], and the thrust noise reaches [Formula: see text] at 0.1 Hz. The result demonstrates that the scheme has the potential to be applied to gravitational wave detection missions.
Optimal demand management of smart energy hybrid system based on multi-objective optimization problem
Authors: Askar Shavan , Sadikova Albina , Mohammed Rajaa Jasim , Khalaf Hameed Hassan , Ghazaly Nouby M. , Radhan R. P. , Candra O. C.
Published: July 2024

This paper presents a multi-objective problem for the energy planning of an energy hybrid system. The problem considers three main objectives: minimizing emission pollution and operation cost on the generation side, addressing consumers’ dissatisfaction with the electrical demand, and reducing deviation from optimal levels in the 24 hours ahead to flatten demand profiles. To achieve this, a demand flexibility strategy is implemented, involving the optimal shifting of electrical demand using deferrable loads. The proposed approach utilizes the augmented epsilon-constraint method to identify Pareto solutions for the objectives. Additionally, the TOPSIS decision-making technique is employed to select the optimal solution from the set of Pareto solutions. The effectiveness and robustness of the proposed approach are validated through two case studies. Overall, the paper highlights the importance of considering multiple objectives in the energy scheduling of hybrid systems and demonstrates the effectiveness of the proposed approach in achieving a balance between environmental, economic, and consumer satisfaction goals. The use of demand flexibility strategies and multi-objective optimization techniques can significantly improve the operation of energy systems, paving the way for more efficient energy management practices. The implementation of demand-side management has resulted in a significant reduction of 2.8% and 64.9% in the first and second objectives, respectively, compared to the absence of such management.
The role of karyosystematics in the taxonomy of the genera Sorex and Crocidura (Mammalia: Soricidae), and the state of chromosomal studies of shrews in the Russian Far East
Authors: Kartavtseva I.V. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia
Published: July 2024

Literature data on the chromosomal characteristics of Soricidae, genera Crocidura and Sorex are analyzed. The importance of karyological studies for shrew taxonomy at the species level in the Russian Far East is shown. For each species, information on taxonomy, distribution, collection site of studied samples and the structure of karyotypes is provided. The intraspecifi c variability of shrew karyotypes in the Russian Far East is discussed based on a comparison of chromosomal characteristics from diff erent populations located in Russia and other geographical regions.
Scientifi c and pedagogical heritage of Professor Nadezhda Konstantinovna Khristiforova (October 30, 1940 – March 7, 2024)
Authors: Bogatov V.V. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Chernova E.N. , Prozorova L.A. , Shulkin V.M. ,   Pacific Geographical Institute, Far Eastern Branch of the Russian Academy of Sciences, Radio St., 7, Vladivostok, 690041, Russian Federation,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia,   Pacific Geographical Institute, Far Eastern Branch of the Russian Academy of Sciences, Radio St., 7, Vladivostok, 690041, Russian Federation
Published: July 2024

Nadezhda Konstantinovna Khristoforova was an Honored Scientist of the Russian Federation, Professor, Doctor of Biological Sciences, a recognized expert in the fi eld of biogeochemistry and ecology of aquatic ecosystems. She worked at the Pacifi c Institute of Geography, Far Eastern Branch of the Russian Academy of Sciences, for 50 years, and at the Far Eastern University for almost 40 years, having helped to establish 65 candidates and 14 Doctors of Science. This paper briefl y outlines her creative biography and analyzes her scientifi c and pedagogical heritage.
Upaya Meningkatkan Kemampuan Numerasi Anak dalam Menulis Angka 8 melalui Media Vituleka
Authors: Suryantika Renita , Widayati Sri , Maulidiyah Eka Cahya , Hasibuan Rachma , Khumairoh Lulu
Published: July 2024

The learning strategies and media used by educators will influence the success of achieving learning objectives. The use of appropriate media that suits the character of early childhood can support the achievement of learning goals effectively. Good numeracy skills at an early age are a strong foundation for further mathematics learning in the future. This research is based on children's ability to write the number eight (number 8) which is still imperfect. In general, children make the number eight by stacking circles from bottom to top. The aim of this research is to improve the numeracy skills of special children in writing the number 8. This classroom action research was carried out in group A at UNESA Labschool 1 Kindergarten. This classroom action research uses the Kemmis and Mc.Taggart method with two cycles. Each cycle includes planning, implementation, observation and reflection. This research uses video tutorials and children's worksheets (Vituleka). The subjects of this research were 18 group A students. In cycle I, students' numeracy ability in writing the number 8 was 50%. In cycle II, numeracy ability in writing the number 8 became 83.3%, an increase of 33.3% from the previous cycle. Based on research data, Vituleka media can improve students' ability to write the number 8.
Correlation of Isocapnic Buffering Phase with Aerobic and Anaerobic Power in Athletes
Authors: Okur Burçin , Polat Metin , Avcu Emsal Çağla , Hazar Serkan
Published: June 2024

The aim of the study was to detect the relationship of isocapnic buffering phase values with the values of both aerobic and anaerobic power. A total of 14 athletes, five females and nine males, with ages between 18 and 25 volunteered to participate in the present study. At the beginning, the values of height, body mass, and body fat ratio of the volunteers were collected as required. Then, a maximal exercise test was applied to the volunteers and during the test, the values of maximal oxygen consumption capacity (VO2max), amount of oxygen consumed (VO2), amount of carbon dioxide produced (VCO2), ventilatory threshold, respiratory compensation point, and maximal heart rate were determined. Isocapnic buffering and hypocapnic hyperventilation phases were determined from the ventilatory threshold and respiratory compensation point values. One week after the maximal exercise test, the Wingate anaerobic test was applied to the volunteers and anaerobic power values were calculated. A significant relationship was found between the values of isocapnic buffering and hypocapnic hyperventilation, and the values of maximal heart rate (beats/min), ventilatory threshold VO2 (ml/kg/min), ventilatory threshold heart rate (beats/min), ventilatory threshold speed (km/hour), respiratory compensation point heart rate (beats/min), and respiratory compensation point speed (km/hour) in both male and female volunteers. The findings collected hereby indicate that as the VO2max levels of athletes increase, both their cardiopulmonary data and anaerobic power values and also their ability to resist the intensity of exercises applied after entering anaerobic threshold, increase.
Development of Sustainable Yarns from an Innovative Combination of European Hemp and Pure Recycled Wool
Authors: Streitenberger Lisa , Holderied Prisca , Klausmann Julia , Mutschler Thomas , Pattberg Daniel , Weide Thomas , Weber Macus
Published: June 2024

Currently, only a very small percentage of textiles is recycled; the majority is incinerated or sent to landfill. Due to the advancing climate change, the responsible use of available resources is becoming more important than ever. The process of rethinking begins in product development with the selection of raw materials. In the project “CannaReWool” (EFRE-0802000), German hemp and pure recycled wool are blended, spun and knitted into fabrics. The aim of the project is to produce knitted fabrics that can be recycled in a closed loop due to their novel combination of materials. The aim is to determine the most suitable settings and spinning components to ensure a stable rotor spinning process. The evaluation is based on the number of yarn breaks per rotor hour. The trials are carried out on the Schlafhorst Autocoro 480 rotor spinning machine. As both fibers, hemp and recycled wool, are very short and lack fiber to fiber cohesion, it becomes apparent that no settings can be found that give the spinning process sufficient stability. The results of the Uster Tester 6 and the Textechno Statimat tests show that the yarns contain a high amount of imperfections and the tensile strength values are low. Nonetheless the yarn is successfully knitted into fabrics on a Stoll ADF flat knitting machine. In the course of the project, the knitting trials will be continued and areas of application for the fabrics will be determined.
A spiritualist perspective on the novel "The Evening Sacrifice" by Pyotr Boborykin
Authors: Ustimov O. V.
Published: July 2024

The  relevance  of  the  work  is  related  to  the  promising  direction  of  studying  the  influence  of  non-classical  theologies  on  the  poetics  of  literary  texts  of  the  post-Romantic  period.  The  article  examines the spiritual poetics of P.D. Boborykin's novel "The Evening Sacrifice". The cultural-historical method allows us to determine the place of spiritual views and practices in the culture and literature of the 19th century, in the consciousness of society and the authors of literary texts. The article analyses the  peculiarities  of  the  representation  of  members  of  the  spiritualist  movement  in  P.D.  Boborykin's novel  "The  Evening  Sacrifice".  The  comparative  method  is  used  to  compare  the  representation  of  spiritualists  in  Boborykin’s  novel  with  that  of  his  contemporaries  –  I.S.  Turgenev,  L.N.  Tolstoy,  F.M.  Dostoevsky.  If  for  Turgenev  and  Tolstoy,  the  fascination  with  spiritualism  is  another  sign  of  the idleness and meaninglessness of the aristocracy's life (and in Tolstoy's case, it is also an occasion to show  the  superiority  of  peasants  over  it),  then  for  Dostoevsky,  spiritualism  reveals  the  peculiarities  of  the  relationship  between  faith  and  fact  for  a  person,  which  allowed  him  to  deduce  the  concept  of  "true  realist" Alyosha in “The Brothers Karamazov”, and for Boborykin it is an alternative value system that  allows  one  to  reconsider  their  moral  and  intellectual  views  by  comparing  them  with  it.  The  revealed  differences allow us to establish the individual characteristics of the views of each of the selected authors. The semiotic method allows us to trace the features of the construction of the poetics of literary texts and the role that spiritualism plays in it. Allan Kardec's religious and philosophical views, which include faith in the evolution of the soul through a series of reincarnations, which can be achieved under the guidance of helping souls of a higher level of development, turn out to be a way of organising the structure of P.D. Boborykin's novel "The Evening Sacrifice", the basis for the dynamics of its plot and the connection of characters. Spiritualism also plays a role in the specifics of the novel's gender issues, which is confirmed by the author's out-of-text testimonies. The results of the research can be applied in the study of the history of Russian literature and the sociology of religion.