bluuebunny/crossref_metadata_2025 huggingface dataset:
Feedback of actionable individual patient prescription data to improve asthma prescribing: pragmatic cluster randomised trial in 233 UK general practices
Authors: MacBride-Stewart Sean , Marwick Charis , Ryan Margaret , Guthrie Bruce
Published: May 2022

Background

Potentially inappropriate prescribing (PIP) of asthma bronchodilator inhalers is associated with increased morbidity and mortality.

Aim

To evaluate the effectiveness of feedback on the PIP of bronchodilator inhalers.

Design and setting

Pragmatic cluster randomised trial involving 235 of 244 (96.3%) GP practices in one Scottish health board.

Method

Practices were randomly allocated (1:1 ratio) to individualised feedback (including visualised medication histories for each patient and action-oriented messages) on PIP of bronchodilator inhalers from prescription data; feedback reports were sent in July 2015, February 2016, and August 2016. Controls were sent feedback on an unrelated subject. The primary outcome was the change in the mean number of patients per practice with PIP of bronchodilator inhalers from the baseline period (August 2014–July 2015) until the post-feedback period (February 2016–January 2017), identified through a composite of five individual measures using prescription data.

Results

In the analysis of the primary outcome, the mean number of patients with PIP of bronchodilator inhalers fell in the 118 practices that were sent feedback from 21.8 per practice to 17.7 per practice. Numbers fell marginally in the 115 control practices, from 20.5 per practice to 20.2 per practice, with a statistically significant difference between the two groups. There were 3.7 fewer patients per practice with PIP of bronchodilator inhalers in the intervention practices versus the control practices (95% confidence interval = −5.3 to −2.0).

Conclusion

Individualised feedback of PIP of asthma bronchodilators that included background information, visualised medication histories for each patient, and action-oriented messages was effective at reducing the number of patients exposed to excess or unsafe prescribing of bronchodilator inhalers.
Perspectives of GPs working in or alongside emergency departments in England: qualitative findings from the GPs and Emergency Departments Study
Authors: Anderson Helen , Scantlebury Arabella , Leggett Heather , Salisbury Chris , Benger Jonathan , Adamson Joy
Published: May 2022

Background

Around 43% of emergency department (ED) attendances can be managed in general practice. Strategies to address this include directing appropriate patients to GPs working in or alongside EDs (GPED). Views of GPs choosing to work in GPED roles may inform planning and implementation of GPED services as well as wider general practice provision.

Aim

To explore the experiences and motivations of GPs choosing to work in GPED services in England, and to identify factors that may support or hinder GPs working in GPED roles.

Design and setting

Thematic analysis of 42 semi-structured interviews of GPs working in 10 GPED case sites across England.

Method

Qualitative GP interviews from a mixed-methods study of GPs in GPED roles were thematically analysed in relation to research aims.

Results

Four themes were generated: the ‘pull’ of a portfolio career; the ‘push’ of disillusionment with general practice; professional reciprocity; sustainability of GPED services and core general practice. Flexible, favourable working conditions, collaboration, and professional development made GPED an attractive workplace, often as part of a portfolio career or after retiring from core general practice. Working in GPED services was largely driven by disillusionment with core general practice. Both GPED and core general practice were thought to benefit from GPED GPs’ skills. There were concerns about GPED sustainability and destabilisation of core general practice.

Conclusion

GPED may extend the clinical careers of experienced GPs and support recruitment and retention of more recently qualified GPs. Despite some benefits, GPED may destabilise core general practice and increase pressure on both environments.
Early implementation of the structured medication review in England: a qualitative study
Authors: Madden Mary , Mills Thomas , Atkin Karl , Stewart Duncan , McCambridge Jim
Published: May 2022

Background

NHS England has introduced a new structured medication review (SMR) service within primary care networks (PCNs) forming during the COVID-19 pandemic. Policy drivers are addressing problematic polypharmacy, reducing avoidable hospitalisations, and delivering better value from medicines spending. This study explores early implementation of the SMR from the perspective of the primary care clinical pharmacist workforce.

Aim

To identify factors affecting the early implementation of the SMR service.

Design and setting

Qualitative interview study in general practice between September 2020 and June 2021.

Method

Two semi-structured interviews were carried out with each of 10 newly appointed pharmacists (20 in total) in 10 PCNs in Northern England; and one interview was carried out with 10 pharmacists already established in GP practices in 10 other PCNs across England. Audiorecordings were transcribed verbatim and a modified framework method supported a constructionist thematic analysis.

Results

SMRs were not yet a PCN priority and SMR implementation was largely delegated to individual pharmacists; those already in general practice appearing to be more ready for implementation. New pharmacists were on the primary care education pathway and drew on pre-existing practice frames, habits, and heuristics. Those lacking patient-facing expertise sought template-driven, institution-centred practice. Consequently, SMR practices reverted to prior medication review practices, compromising the distinct purposes of the new service.

Conclusion

Early SMR implementation did not match the vision for patients presented in policy of an invited, holistic, shared decision-making opportunity offered by well-trained pharmacists. There is an important opportunity cost of SMR implementation without prior adequate skills development, testing, and refining.
Detrital Zircon U-Pb Geochronology Results for the Bountiful Peak, Coalville, James Peak, Mount Pisgah, Paradise, and Payson Lakes 7.5' Quadrangles, Utah
Authors: McKean Adam P. , Anderson Zachary W. , Clark Donald L. , Fernandez Diego , Anderson Christopher R. , Rivera Tiffany A. , McCombs Taylor K.
Published: May 2022

This Open-File Report makes available raw analytical data from laboratory analysis of U-Pb ages of zircon grains from samples collected during geologic mapping funded by the U.S. Geological Survey (USGS) National Cooperative Geologic Mapping Program (STATEMAP) and the Utah Geological Survey (UGS). The references listed in table 1 provide additional information such as sample location, geologic setting, and interpretation of the samples in the context of the area where they were collected. The data were prepared by the University of Utah Earth Core Facility (Diego Fernandez, Director), under contract to the UGS. These data are highly technical in nature and proper interpretation requires considerable training in the applicable geochronologic techniques.
THE EFFECT OF AGRICULTURAL EXPLANATION ON RICE PRODUCTIVITY (Oryza sativa L.) (Case: Kerapuh Village, Dolok Masihul District, Serdang Bedagai Regency)
Authors: Pane Mutiara
Published: May 2022

The purpose of this study was to determine the implementation of the agricultural extension program in Kerapuh Village, Dolok Masihul District, Serdang Bedagai Regency. This study aims to determine the effect of agricultural extension factors on lowland rice productivity in Kerapuh Village, Dolok Masihul District, Serdang Bedagai Regency. The analytical method used in this research is descriptive method and multiple linear regression analysis method using SPSS 17. Determination of the research location is done purposively. The sampling technique used is simple random sampling method with a total sample of 52 respondents. This research was conducted in 2018. The results show that the characteristics of the most respondents are in the age group 51-55 years where the percentage is 37%, the education of the most respondents is at the elementary education level where the percentage is 37%, length of farming The highest number is in the group 21-25 where the percentage is 35%. The implementation of the agricultural extension program in Kerapuh Village, Dolok Masihul District, Serdang Bedagai Regency is quite good. Educational factors, length of time in farming, extension programs and competency of extension workers have a significant effect on productivity in the research area.
ANALYSIS OF RED WATERMELON AND YELLOW WATERMELON FARMING (Case Study: Secanggang District, Langkat Regency)
Authors: Harahap Ahmad Riandy
Published: May 2022

The purpose of this study was to determine the development of red watermelon and yellow watermelon in the last 5 years; to analyze the characteristics of red and yellow watermelon farmers; to analyze the income of red and yellow watermelons; to analyze the feasibility and to determine the effect of production factors on the acceptance of red watermelon and yellow watermelon. The data analysis method used is the income analysis method; R/C Ratio and B/C Ratio analysis methods; multiple regression analysis methods. From the results of the study, it was found that the production and area of ??red watermelon and yellow watermelon farming land continued to increase over the last 5 years; yellow watermelon farming income is greater than red watermelon farming income; Yellow watermelon farming is more feasible than red watermelon.
RETURN COST AND VALUE ADDED ANALYSIS OF SWEET POTATO PROCESSING (Case Study: Pasar Bengkel Village, Perbaungan District, Serdang Bedagai Regency)
Authors: Fatmala Evi
Published: May 2022

The purpose of this study was to identify how much income was obtained from processing sweet potatoes into chips and chicken claws and to identify how much value added was obtained from the chips and chicken claw business in the research area. The analytical method used is the method of income analysis with the method of calculating the Cost of Return and the method of value added analysis using the Hayami calculation method. The conclusion from the research results that the value obtained from processing sweet potatoes into chips is Rp. 4,247,914,-/ Month, while the added value of the sweet potato processing industry into chips is Rp. 1,167.37, with a value added ratio of 24.39% per month is relatively low. While the average income of chicken claw business in Delimada Village, Perbaungan District, Serdang Bedagai Regency is Rp. 4,436,460, -/ month while the added value of the sweet potato processing industry into chicken claw is Rp. 714.75, with a value added ratio of 16.42% per month is relatively low. The obstacle faced by the sweet potato processing industry in Pasar Bengkel Village, Perbaungan District, Serdang Bedagai Regency is the lack of availability of raw materials and labor.
Utilizing Technology: Knowledge Applications for Millennial Entrepreneurs
Authors: Paulus Ardianus Laurens
Published: May 2022

This study aims to determine the effect of one of the processes in knowledge management, namely knowledge application on millennial entrepreneurs in utilizing technology in business processes. The research sample is millennial entrepreneurs with 153 respondents through an online survey via a google form. Data analysis using confirmatory factor analysis, descriptive test, and regression test. According to the findings of this study, knowledge application has a substantial impact on the use of millennial entrepreneurial technologies. Smartphones are the most commonly utilized information technology media among millennial entrepreneurs in this study. The millennial entrepreneurship promotion media tools studied use social media and the type of business for millennial entrepreneurs is dominated by the fashion business.
Analysis of Organizational Commitment against Employee Performance with Organizational Culture Moderation (Study at Walisongo State Islamic University (UIN) Semarang)
Authors: Sutaat Sutaat
Published: May 2022

This research that is done  in University  Agama Islam Walisongo Semarang. Data used by primary data taken with questionnaire with 82 respondents for sample research. The writer did the reseach  by using purposive sampling, with  some criteria. Those criteria are the respondents have to  had level stratum -2 for level education and tree year  minimum in a work periode. Analysis appliance weared by instrument test, the test reliability, and while the test models, test the Adj R2 (coefficient of determination), Test the hypothesizing used regression analysis, test the F Test (Goodness of Fit), and test the moderation using analysis path (path analysis). The results of the analysis in this study resulted in regersi determination coefficient of 0.423, or in other words, changes in performance can be influenced by effective commitment, continuance commitment, normative commitment and organizational culture of 43.3%. The results of this study indicate that affective commitment does not affect the employee performance, ccontinuance commitment has the influence a significant effect on employee performance, normative commitment does not effect on employee performance, organizational culture did not moderate the influence of affective organizational commitment to employee performance, organizational culture  did’t  moderate the influence of continuance organizational commitment to employee performance and organizational culture moderates the effect of normative commitment on employee performance.
Independence of Financial Performance of Jombang Regency Regional Government
Authors: Suprapto Sugeng
Published: May 2022

With regard to the granting of autonomy, regions are obliged to find alternative development funding without reducing the expectations of central government support. The purpose of this study was to analyze the ratio of financial independence of Jombang Regency in five years, namely 2016 to 2020.  This study uses qualitative descriptive methods. (especially the central and provincial governments) is very high. Data collection by observation and dokumkentasi. Data analysis by trianggulation. The results showed that the average ratio of independence of Jombang Regency for five years from 2016 to 2020 was 30% so that in the low category and showed a pattern of consultative relations this means that the level of regional dependence on external assistance
Motivation as a Mediation on Organizational Culture and Compensation and its Effect for Performance
Authors: Carolina Lewaherilla Novalien , Ernest Huwae Victor
Published: May 2022

This study aims to analyze the influence of organizational culture, compensation on employee performance with work motivation as a mediation. The sample taken is all employees of Bank Artha Graha as many as 31 respondents. The results of this study indicate that: (1) organizational culture has a positive and significant effect on work motivation, (2) compensation has a positive and significant effect on work motivation, (3) culture organization has a positive and insignificant effect on employee performance, (4) compensation has a positive and significant effect on employee performance, (5) work motivation has a positive and significant effect on employee performance.
INSUFFICIENT CONTROL OF OUT-OF-OFFICE BLOOD PRESSURE: THE PROBLEM OF MASKED UNCONTROLLED HYPERTENSION: review
Authors: Shalimova Anna
Published: May 2022

Despite significant advances in the diagnosis and treatment of arterial hypertension (AH), the problem of insufficient blood pressure (BP) control in hypertensive patients is quite acute. According to current guidelines, the effectiveness of antihypertensive therapy is mainly assessed by reaching the target levels of office BP, while masked uncontrolled hypertension (MUCH), which is diagnosed on the basis of insufficient control of out-of-office BP, increases the risk of cardiovascular events. Patients with insufficient out-of-office BP control have an increased risk of cardiovascular events compared to patients with both office and out-of-office BP control, therefore MUCH requires timely diagnosis and correction.

This mini-review summarizes the understanding of the nature of MUCH. A particular attention is paid to risk factors and ways of influencing the out-of-office BP control. The article also assessed the important contribution of ABPM to the control of out-of-office BP and to determining the overall risk of MUCH.
MODERN METHODS OF DIAGNOSIS AND SCREENING OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS STAGES: review
Authors: Zhelezniakova Natalia , Babak Oleg , Aleksandrova Tetiana
Published: May 2022

The review is devoted to the problem of diagnosing one of the most common pathologies of the modern world – non-alcoholic fatty liver disease (NAFLD). Data from experimental and clinical studies on the importance of various instrumental and biochemical methods of non-invasive diagnosis ofnon-alcoholic steatohepatitis (NASH) and liver fibrosis (LF) are presented. New non-invasive diagnostic methods of NASH and LF are considered.
FLOW CYTOMETRY IN NANOTOXICOLOGY: brief overview
Authors: Tkachenko Anton , Onishchenko Anatolii , Butov Dmytro , Tkachenko Maryna
Published: May 2022

The paper deals with the role of flow cytometry in assessing the biocompatibility and safety profiles of nanomaterials. Flow cytometry is a powerful tool to characterize the impact of various exogenous factors on different cell populations due to its ability to register optical and fluorescence characteristics of cells analyzing multiple parameters simultaneously. An overview of flow cytometry application for evaluating the redox state of cells, viability and cell death modes (apoptosis, necrosis, necroptosis, pyroptosis, autophagy), and pro-inflammatory effects of nanoparticles is provided.

Flow cytometry offers rapid, informative, quite cost-effective and multi-angled analysis of safety profiles of nanomaterials taking into account the key mechanisms of their toxic action. Recent advances in flow cytometry technologies and the availability of commercial automated cell counters make flow cytometry a convenient research tool for in vitro nanotoxicology. However, the field requires the development of standardized flow cytometry protocols for nanotoxicity testing.
FRACTAL DIMENSION IN MORPHOLOGY AND MEDICINE: THEORETICAL BASES AND PRACTICAL APPLICATION: review
Authors: Maryenko Nataliia , Stepanenko Oleksandr
Published: May 2022

Morphometry is an integral part of most modern morphological studies and the classic morphological morphometric methods and techniques are often borrowed for research in other fields of medicine. The majority of morphometric techniques are derived from Euclidean geometry. In the past decades, the principles, parameters and methods of fractal geometry are increasingly used in morphological studies. The basic parameter of fractal geometry is fractal dimension. Fractal dimension allows you to quantify the degree of filling of space with a certain geometric object and to characterize the complexity of its spatial configuration. There are many anatomical structures with complex irregular shapes that cannot be unambiguously and comprehensively characterized by methods and techniques of traditional geometry and traditional morphometry: irregular linear structures, irregular surfaces of various structures and pathological foci, structures with complex branched, tree-like, reticulated, cellular or porous structure, etc. Fractal dimension is a useful and informative morphometric parameter that can complement existing quantitative parameters to quantify objective characteristics of various anatomical structures and pathological foci. Fractal analysis can qualitatively complement existing morphometric methods and techniques and allow a comprehensive assessment of the spatial configuration complexity degree of irregular anatomical structures. The review describes the basic principles of Euclidean and fractal geometry and their application in morphology and medicine, importance and application of sizes and their derivatives, topological, metric and fractal dimensions, regular and irregular figures in morphology, and practical application of fractal dimension and fractal analysis in the morphological studies and clinical practice.
Toplumda Afet Farkındalığı Oluşturmaya Yönelik Kullanılan Araçlar: Nitel Bir Çalışma
Authors: ÖZDEMİR Ahmet , ŞAHİNÖZ Turgut
Published: May 2022

Afetler insanların olumsuz tutum ve davranışlarının sonucu karşılaşılan yıkıcı etkilere sahip durumlardır. Afetlerden korunmanın en önemli yolu afete sebep olan insanların farkındalıklarının arttırılmasından geçmektedir. Toplumda afet farkındalığının geliştirilmesine yönelik kullanılan birçok araç bulunmaktadır. Bu araçların afiş, broşür, kitapçık, televizyon, radyo, internet ve sosyal medya, çalıştay, sempozyum ve paneller olduğu söylenebilir. Bu çalışmanın temel amacı, toplumda afet farkındalığı oluşturmaya yönelik kullanılan araçların, toplumun afet f arkındalığı üzerindeki etkisinin olumlu ve olumsuz yanlarına değinerek çözüm önerileri sunmaktır. Araştırma, nitel bir araştırma olarak tasarlanmış ve nitel araştırma yöntemlerinden fenomenoloji yaklaşımı benimsenmiştir. Katılımcılar ölçüt örneklem yöntemi kullanılarak Kocaeli ilinde yaşayan ve afet konusunda çalışan kişiler arasından seçilmiştir. Seçilen 12 katılımcı ile yarı yapılandırılmış mülakatlar gerçekleştirilip ses kaydı alınmıştır. Elde edilen verilere MAXQDA 2020 nitel veri analiz programı kullanılarak içerik analizi uygulanmıştır. İçerik analizi sonucunda 6 kategori elde edilmiş olup, bu kategoriler 2 tema altında toplanmıştır. Kocaeli ilinde afet farkındalığı konusunda hazırlanan afiş, broşür ve kitapçıklara yeterince ilgi gösterilmediği sonucuna ulaşılmıştır. İnternet, sosyal medya ve televizyon üzerinden yapılacak bilgilendirmeler daha etkili bir şekilde gerçekleştirilmelidir. Ayrıca, afet farkındalığı konusunda gerçekleştirilen panel, seminer ve çalıştaylara halk katılımı yeterli seviyede sağlanmalıdır.
Fostering Diversity and a Culture of Inclusion in Clinical Research by Training and Hiring Community Members as Clinical Research Assistants
Authors: Collinger Katelyn , Yasko Laurel , Smalley Denise , Rassau Kimberly , Strickland William E. , Reis Steven E.
Published: May 2022

The University of Pittsburgh (Pitt) Clinical and Translational Science Institute (CTSI) and the nonprofit Bidwell Training Center co-developed a new program for translational workforce diversification and development to foster diversity and inclusion in clinical research. The STricklAnd Research Training (START) program provides students in the Medical Assistant program at Bidwell a career path in clinical research. We created a 12-hour didactic package that covers responsible conduct of human subjects research and good clinical practice as an add-on to existing vocational curriculums. Students have the option of completing a clinical research-related externship at Pitt, which includes mentoring, shadowing, and protocol-specific training on a study team whose intention is to hire them as a clinical research assistant. Those who accept a position at Pitt receive continued mentorship, education, and professional development through Pitt CTSI. In the first three cohorts, two of which had access to research externships at Pitt, 92% of students successfully completed the instruction in clinical research. We plan to expand START to new venues to train and hire local community members from diverse backgrounds who can bring their lived experience to research programs.
Risks of Visual Impairment and Its Progression in Children and Adolescents
under Modern Conditions of Education and Upbringing: A Scientific Review
Authors: Shubochkina EI , Vyatleva OA , Blinova EG
Published: May 2022

Introduction: Intensive introduction of digital technologies and educational tools poses risks of visual impairment in children and adolescents as the most active users of the digital space.
Objective: To assess risks of visual impairment in children and adolescents in the context of active dissemination of digital technologies in education and everyday life based on a literature review in order to choose directions for pediatric prevention of eye diseases.
Materials and methods: We did a review of Russian and English language scientific literature published in 2007–2021, found on eLIBRARY.RU, PUBMED, Web of Science, and Scopus information portals and platforms. We selected 48 articles containing
an evidence-based assessment of risks of eye diseases related to e-learning and long screen time in children and adolescents, especially during the COVID-19 pandemic and associated lockdown.
Results: We observed combined risks of visual impairment and musculoskeletal disorders due to violation of hygienic requirements for illumination, working posture, distance to the screen, and screen time when using various gadgets. Concomitant risk factors for eye diseases related to vitamin D deficiency were evaluated.
Conclusions: We identified groups at risk of visual impairment based on health indicators and the intensity of using the digital environment. We also specified basic methodological and regulatory documents, the compliance with which could reduce the risks of visual impairment in children, adolescents, and students, and proposed up-to-date directions of research on the topic of the review for maintenance of eye health.
Calvino e Bruner, Lezioni Americane e Italiane allo Specchio
Authors: Mancini Irene , Marsico Giuseppina
Published: May 2022

È il 1985 ed Italo Calvino si impegna a redigere lezioni da tenere presso l’Università di Harvard. Si tratta di un ciclo di sei conferenze, le Charles Eliot Norton Poetry Lectures, nelle quali l’autore italiano avrebbe dovuto affrontare argomenti legati alla comunicazione poetica. È il 2001 e Jerome Bruner viene invitato a tenere presso l’università di Bologna le prime lezioni “italiane” del nuovo millennio. Bruner sceglie di discutere di letteratura, diritto e vita. Le lezioni del primo sintetizzano nuclei fondamentali del pensiero di Calvino, le seconde orientano le ricerche in campo psicologico ed educativo di Bruner. In questo articolo si è tentata una lettura comparata di due testi: Lezioni Americane di Italo Calvino (1993) e La Fabbrica delle Storie (2002) di Bruner rintracciando sorprendenti immagini complementari che offrono spunti preziosi per comprendere l’importanza della narrazione nella costruzione dell’identità individuale e collettiva.
DEVELOPMENT OF INNOVATIVE INFRASTRUCTURE AS A BASIS OF DIVERSIFICATION PROCESSES OF UKRAINE'S ECONOMY
Authors: Kublikova Tetiana , Kuznetsova Inna
Published: May 2022

Introduction. The subject of research is the analysis of forms and features, advantages and disadvantages of economic structure diversification. The relationship between the choice of models for the diversification of traditional or innovative and the creation of innovative infrastructures of the country. Modern conditions, directions, and problems of the innovation infrastructures development in Ukraine are investigated. The current state of innovative infrastructures park development is analyzed. Measures to improve the efficiency of their operation are proposed.
The purpose and objectives of the study are to analyze the relationship between the development of innovation infrastructure and the processes of economic diversification and the identification of problems and ways to improve its efficiency.
Method (methodology). The systematic approach, methods of analysis and synthesis are applied; the regulatory framework and reporting data of the State Statistics Service of Ukraine were used as an information basis.
Results. Recommendations have been developed to ensure favorable conditions for the development and functioning of effective innovation infrastructure.
Conclusions. One of the ways to successfully survive in a competitive environment is economic diversification, which forms the country's innovation infrastructure. The creation of innovative infrastructures and their successful development and operation objectively determines the emergence of intensive processes of diversification of the economy of regions and the country as a whole on a qualitatively new basis of innovative high-tech growth, reproduction of various goods and services. These structures give rise to two types of diversification – innovative when the production of innovative goods and services happens, and traditional diversification, which is expressed in a variety of ancillary activities necessary for their proper functioning. To maintain their competitiveness, economic entities must constantly maintain sustainable and efficient forms of economic systems, implement and master the innovations production, modifications, i. e.combine traditional and innovative activities. This is a productive and promising interaction of the processes of traditional and innovative diversification of economic entities in the economic system. However, despite the existence of some elements of the economic diversification system, today, the country lacks a holistic model for the development of effective innovation infrastructure. The existing in Ukraine separate structural elements of the innovation system and the legal field of their functioning are not built into a single innovative economic system, so the results of these elements are isolated and have no synergistic effect. The recommendations provided in the article help to provide favorable conditions for the formation and functioning of the effective innovation infrastructure in Ukraine.
TRENDS AND ORIENTIRES OF BRAND DEVELOPMENT OF PHARMACEUTICAL COMPANIES IN UKRAINE
Authors: Yamnenko Halyna
Published: May 2022

Introduction. In a highly competitive environment, only companies that are able to distinguish themselves from their competitors can be successful in the long term. Ensuring real differentiation is an extremely difficult task. To do this, it is necessary to offer a product that is different from the competition, which has a historically superior performance characteristics and to add vivid imagery to the product, appealing to the emotions of consumers. The basis for successful existence and maintenance of high level of competitiveness of the product on the market is the brand, which in its turn, ensures for the consumers a high level of rational and emotional values, which leads to maintenance of the necessary differentiation of the company's activity and positive financial result.
Purpose – research of peculiarities of formation and development of the brand of enterprises in the pharmaceutical market.
Method. During the research we used methods of comparative analysis, systematic approach, summarization, synthesis, logical and structural analysis, graphical interpretation.
Results. An analysis of the situation was carried out, trends in the activities of pharmaceutical companies were identified. In the formation of brand development strategy it was suggested to pay attention to continuous brand management and increase of promotional activity of the companies.
Practical relevance lies in influencing the process of brand planning and determining the development criteria for enterprise brands.
ORGANIZATION OF ECONOMIC ANALYSIS AT THE ENTERPRISE
Authors: Novichenko Lyudmyla
Published: May 2022

Introduction. Operational and reliable information support for management decisions depends on the organization and correctness of the formation of information flows in the enterprise. One of the mechanisms to ensure the formation of an appropriate information base for the enterprise management system is the system of economic analysis. Rational organization of economic analysis ensures proper streamlining and development of effective mechanisms for analytical work at the enterprise and the appropriate design of the results of the calculation of analytical indicators.
Purpose. Investigate the features of the organization of economic analysis in the enterprise, to establish its main components, as well as identify ways to improve the organization of analytical work in the enterprise.
Method (methodology). Methods of analysis, synthesis, induction, deduction, generalization, method of system approach, grouping, tabular method were used to achieve the goal of the work.
Results. The author's definition of the concept of «organization of economic analysis» is offered and the peculiarities of rational organization of economic analysis are established. The basic questions which should be solved at each stage of the organization of the economic analysis at the enterprise are opened and detailed. Based on the analysis of existing developments and the authors' proposals to determine the main elements of the organization of economic analysis, its system-process interpretation is proposed. The expediency of studying the organization of economic analysis on the basis of systemic and procedural approaches is proved. Based on the results of their application, the main elements of the organization of economic analysis are identified and their characteristics are given. Using the proposed approach to the organization of economic analysis will streamline and establish proper coordination and avoid duplication in the analytical functions of economic analysis, strengthen competitive advantages and provide adequate information support for sustainable development of the enterprise.
"ON THE IMPORTANCE OF VARIATION OF ALKALISATION CONDITIONS ON CELLULOSE ETHER SYNTHESIS"
Authors:   MoRe Research AB, SE-891 22 Örnsköldsvik, Sweden, REYES FORSBERG DIANA CAROLINA , SUNDMAN OLA ,   Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden
Published: May 2022

With a multivariate approach, we investigate and correlate the effect of mercerization conditions on the properties of a cellulose ether. We have chosen to work with carboxymethylcellulose (CMC) for analytical reasons. As expected, the DS was found to increase when the NaOH/AGU (anhydroglucose unit) stoichiometric ratio (r) was increased (range 1.0–1.3) and [NaOH] was decreased (range 50-30%). However, such changes also favoured the formation of unwanted side products. Decreased (r) and increased [NaOH] resulted in increased heterogeneity, and thus the quantities of insoluble particles and unreacted chemicals also increased. As another result, the prediction between mercerisation and synthesis weakens. Consequently, a DS of 0.18–0.7 was obtained; the measured solubility was much lower than expected. A non-statistical distribution of substituents was further found. Interestingly, the relative importance of substitution at increases with an increased [NaOH].
POLYSACCHARIDE-BASED MATRIX DOPED WITH PLANT EXTRACT FOR MEDICAL AND COSMETIC APPLICATIONS
Authors:   ", ANGHEL NARCIS ,   “Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A,  700487 Iasi, 40 Romania ", MELINTE VIOLETA ,   "“Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A,  700487 Iasi, 40 Romania "
Published: May 2022

Herein, we present a new biomaterial based on xanthan, chitosan and lignin, which served as a matrix for the incorporation of flavonoids extracted from Agropyron repens L. rhizomes. The simultaneous presence of lignin and xanthan esterified with acrylic acid leads to better retention of the active principles in the polymer matrix, which is reflected in their slow release into the environment. A more compact structure resulting from the incorporation of lignin into the chitosan/xanthan matrix contributed to a three times higher value of diametral tensile strength. The release kinetics of flavonoids through the matrix components was described by the Korsmeyer-Peppas model, indicating Fickian diffusion. The presence of bioactive principles extracted from Agropyron repens L. (couch grass) imparts an antioxidant capacity to biomaterials, on average 30% higher compared to that of the base matrix. Considering the mucoadhesiveness, bioadhesiveness, release kinetics and antioxidant capacity of all the formulations developed in this study, it can be concluded that they have potential for health and cosmetic applications.
CELLULOSE/WOLLASTONITE BASED GREEN MEMBRANES USING RICE STRAW: FABRICATION AND CHARACTERIZATION
Authors:   ", MOKHTARI JAVAD ,   Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), Iran  ", KANAFCHIAN MOTAHAREH ,   "Department of Textile Engineering, Faculty of Engineering,  University of Guilan, Guilan, Iran "
Published: May 2022

Cellulose/wollastonite membranes were prepared with an environmentally friendly process using N-methylmorpholine-N-oxide (NMMO), which resulted in mesoporous membranes with slit-shaped pores. Cellulose and wollastonite were extracted from rice straw with different methods. Some parameters, such as weight ratios of cellulose and wollastonite in solution, concentration, thickness of the cast solution on the support layer and porosity of the support layer, influence the formation of the porous cellulose/wollastonite membrane. It was concluded that the porosity and pore size of the cellulose/wollastonite membrane decreased with lower cellulose and higher wollastonite amounts. The membranes became more brittle by increasing the amount of wollastonite, while pure cellulose membranes did not have enough strength to be placed on the polyester support layer. Also, the concentration of cellulose should not be too high or too low. The thickness of the cast solution on the support layer should not be too high, as it reduces the porosity; on the other hand, low thickness reduces the performance of the membrane.
PREPARATION AND PROPERTIES OF NOVEL BIOCOMPATIBLE PECTIN/SILICA CALCIUM PHOSPHATE HYBRIDS
Authors:   National Research Centre, Cellulose and Paper Department, Dokki 12622, Egypt, ABOUZEID RAGAB E. , ABD EL-KADER AMAL H. ,   National Research Centre, Cellulose and Paper Department, Dokki 12622, Egypt, SALAMA AHMED ,   National Research Centre, Cellulose and Paper Department, Dokki 12622, Egypt, FAHMY TAMER Y. A. ,   National Research Centre, Cellulose and Paper Department, Dokki 12622, Egypt, EL-SAKHAWY MOHAMED ,   National Research Centre, Cellulose and Paper Department, Dokki 12622, Egypt
Published: May 2022

The development of bioactive polysaccharide-based hybrid materials is necessary for finding new alternatives in the field of biomaterials. As a bioactive water-soluble polysaccharide, pectin was used in this study to prepare reinforced silica gel monoliths through the sol-gel method. In-situ mineralization of calcium phosphate was achieved using calcium chloride and phosphate precursors. The properties of the pectin/silica/calcium phosphate hybrid were examined using FTIR, XRD and SEM/EDX techniques. Based on the results of the tests on kidney (Vero) cell lines, the pectin/silica/calcium phosphate hybrid demonstrated very mild cytotoxicity. In addition, the cytotoxicity of different hybrid concentrations was assessed with an MTT test, and the results demonstrated that their non-cytotoxicity for the concentrations investigated.
Evaluating Community Co-Design, Maintenance and Ownership of Green Spaces in Underserved Communities Using Participatory Research
Authors: Caperon Lizzie , McEachan Rosemary R C , Endacott Charlotte , Ahern Sara M
Published: May 2022

Green space is beneficial for health, and the co-design of green spaces is vital to allow community input into their development and encourage their use. However, to date there is limited evidence about the most effective ways to ensure the co-design, maintenance and ownership of green spaces by communities over time. Participatory methods such as transect walks with photovoice offer an opportunity to explore these issues. This study describes an original participatory project in a deprived, multi-ethnic part of Bradford, UK, which aims to use innovative participatory methods to explore how the maintenance, co-design and ownership of green spaces affect their use for health benefits. Participatory methods will be used to explore local community perceptions of and satisfaction with their local green spaces. Three phases of data collection will be conducted in a longitudinal qualitative study spanning 3 years. Each phase will use transect walks with photovoice and semi-structured interviews (n= 24), and focus groups (participant n=40) in four green space locations in Bradford, UK.
Brief Report: Pitfalls and Potentials in Using Methods From Action Research and Systems Thinking When Engaging and Mobilizing Participants in a Community
Authors: Hansen Anders B. G. , Foxvig Ida , Sakal Gül , Klinker Charlotte Demant , Sidenius Anne
Published: May 2022

This brief report discusses our experiences of exploring recruitment challenges in family-focused alcohol treatment and seeking possible solutions to these challenges. We used methods, inspired by Action Research and Systems Thinking, to engage and mobilize participants in two Danish rural municipalities. In the project, local participation from a broad range of stakeholders and a shared understanding of the local context gave rise to increased focus on and awareness of alcohol challenges in the community. We reflect on the importance of assessing whether a community is ready for change; the importance of integrating capacity-building and implementation from the beginning; the importance of engaging a wide range of stakeholders when creating a system map and the importance of recruiting community leaders to workshops, as implementation requires the engagement of persons who have the authority, capacity, and networks to lead systems changes across the community.
Fabrication and evaluation of rib-waveguide-type wavelength conversion devices using GaN-QPM crystals
Authors: Ishihara Hiroki , Shimada Keiya , Umeda Soshi , Yokoyama Naoki , Honda Hiroto , Kurose Kazuhiro , Kawata Yoshimasa , Sugita Atsushi , Inoue Yoku , Uemukai Masahiro , Tanikawa Tomoyuki , Katayama Ryuji , Nakano Takayuki
Published: May 2022

A GaN crystal comprises two polar structures along the c-axis direction, and functions as a quasi-phase-matching (QPM) crystal by fabricating a periodic inversion structure. We fabricated GaN-QPM crystals to design rib-waveguide-type devices for achieving highly efficient wavelength conversion. The QPM period required for wavelength conversion was calculated in the design phase of the device structure. GaN-QPM crystals with the obtained period were fabricated using double-polarity selective-area growth (DP-SAG). The GaN-QPM crystal was then used to fabricate a second-harmonic generation (SHG) device with a rib waveguide structure. Optical measurements revealed that the device achieved wavelength conversion from 840 to 420 nm. Further, the SHG device exhibited a wavelength conversion efficiency of 1.5 × 10–4% W−1. These results indicated that GaN-QPM crystals fabricated by DP-SAG can be used for wavelength conversion.
Effect of Steel Fibres on Mechanical Properties of Concrete
Authors:   Student M.Tech Structural Engineering Department Of Civil Engineering, Institute Of Aeronautical Engineering, Dundigal, Hyderabad, (Telangana), India., Nagamma* G. , Rao N.Venkat ,   Associate professor, Department of Civil Engineering Institute of Aeronautical Engineering (Autonomous), Dundigal, Hyderabad(Telangana), India., Papolu Dr. Ram Mohan Rao ,   Professor and Head Department Civil Engineering Institute of Aeronautical Engineering (Autonomous), Dundigal, Hyderabad, (Telangana), India.
Published: May 2022

Steel strands are concrete fortifying material which in association with cements invigorates extra ductile just as administer concrete with temperature and shrinkage break control improve break opposition of concrete. A test examination will be made on M-30 evaluation of cement with a water bond extent 0.50 to examination the compressive quality, flexural quality, split adaptability of steel fiber reinforced cement (SFRC) containing filaments at the degrees 0%, 1%, 2% and 3% volume region of catch tain Steel strands of 60 perspective extent will be used. the data got will be dismembered and differentiated and the strong model (0% fiber).An association between viewpoint proportion versus Compressive quality, perspective proportion versus Flexural quality, and viewpoint proportion versus Split elasticity will be contemplated. A near report will likewise be made among cement and fiber concrete.
Quando è l’uomo a fare il casalingo
Authors: Setti Raffaella
Published: May 2022

Qual è il sostantivo maschile equivalente di casalinga?
Analysis of School Financial Management in TK Negeri Pembina 2 Bantan Kabupaten Bengkalis
Authors: Qhoimah Nurul , Munastiwi Erni
Published: May 2022

In financial management educational institutions, it is very important to know what the school needs. With clear and appropriate finances, it will affect the school's operations and education at the school. The purpose of this article is to find out how to manage finances in TK Negeri Pembina 2 Bantan. Collecting data through observation, interviews and documentation. The results of the analysis show that financial management at TK Negeri Pembina 2 Bantan is carried out by planning for the management of BOS funds in 2021-2022 starting with the preparation of the RKAS and the preparation of the RAB as well as the implementation of the use and finally bookkeeping. The realization of BOS fund management has complied with the principles referred to in Government Regulation no. 48 of 2008 article 59.
Role of Digital Media in Achieving Sustainable Development in the Arab World
Authors: Sheikh Hanan Esmaeel Al , Serhan Faisal Ahmad Al
Published: May 2022

Digital media is an important means of effecting change and development within societies in general and considers the strong link between the various interactions that can arise between members of these societies. Media is a concept with multiple meanings and goals, as it deals with studying, downloading and describing the treatment of various social, political, economic, and environmental, health and other phenomena that govern the process of steady development that the world is witnessing in various fields. Digital media in particular - in the modern era - plays important and influential roles in the lives of individuals and societies, as it is entrusted with the responsibility to shed light on the various initiatives and plans that are proposed related to cognitive and behavioral awareness processes that in turn lead to the development of society in general. This study sheds light on digital media technology’s role in achieving sustainable development in the Arab world. Nowadays, digital media has become a vital element, which helps governments and organizations direct their messages to their audiences and create the desired social development and change. Moreover, the study clarifies that many Arab countries still suffer from poverty, illiteracy, backwardness, and environmental issues despite the massive progress of the sustainable development movement in the Arab world right after (RIO)'s declaration. Besides, the study defines the limitations that mostly hinder sustainable development programs. The study also determines the most critical requirements for achieving sustainable development in the Arab world within the digital media framework.