bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Significance of D-dimer Level in Refractory Mycoplasma Pneumoniae Pneumonia
Authors: Huang Xia , Li Dan , Liu Feng , Zhao Deyu , Zhu Yifan , Tang Heng
Published: July 2020

Background
Levels of serum D-dimer (D-D) in children with mycoplasma pneumoniae pneumonia (MPP) were assessed to explore the clinical significance of D-D level in refractory MPP(RMPP).
Method:
A total of 430 patients with MPP were enrolled between January 2015 and December 2015, and divided into a genera MPP (GMPP) group (n = 306) and a RMPP group (n = 124). Clinical data, D-D level, white blood cell (WBC) count, C-reactive protein (CRP), blood sedimentation (ESR), and lactate dehydrogenase (LDH) were compared between the two groups.
Results
(1) Hospitalization time, fever duration, WBC, CRP, LDH, ESR, and D-D were significantly higher in the RMPP group than in the GMPP group, (all P < 0.05). (2) Correlation analysis showed that D-D was positively correlated with WBC, CRP, ESR, and LDH, and could be used to jointly evaluate the severity of the disease. (3) The predictive values of WBC, CRP, ESR, LDH, and D-D for RMPP were further compared using area under the receiver operating characteristic curve(AUC) analysis. D-D had the highest predictive power for RMPP (AUC = 0.923, P < 0.01). When the D-D level was > 738 ng/ml, the predicted sensitivity of RMPP occurrence was 79.8% and the specificity was 93.5%. D-D level also had a good ability to predict pleural effusion and liver injury (AUC = 0.740, P < 0.01 and AUC = 0.812, P < 0.01, respectively). (4) After 1 week of treatment, the levels of D-D in both groups were lower than those before treatment (p < 0.01), but remained outside the normal range in 91.4% of participants, and were moderately or severely increased in 27.1% of the participants, all of whom were in the RMPP group.
Conclusion
Serum D-D levels were significantly increased in patients with RMPP, indicating that severe hypercoagulability and vascular endothelial injury with prolonged duration existed in this patient population. Increased levels of serum D-D may be used as an early predictor of RMPP and the occurrence of complications. Our findings provide a theoretical basis for the early diagnosis of RMPP, early intervention of hypercoagulability, and improvement of microcirculation therapy.
Clinical Analysis of Atelectasis Caused by Influenza A in Xiamen Children’s Hospital Between 2017 and 2019
Authors: Yuan Lin , Bai Ding-zhen , Zhuo Zhi-qiang , Wu Xing-dong
Published: July 2020

Background: We aimed to analyze the clinical characteristics of pediatric patients with atelectasis caused by influenza A to provide a reference for reasonable clinical diagnosis and treatment. Methods: We included 79 pediatric patients with atelectasis caused by influenza A diagnosed at Xiamen Children’s Hospital between January 1, 2017 and December 31, 2019. We analyzed their epidemiological characteristics, clinical manifestations, imaging changes, diagnosis, treatment process, and outcomes. Results: Among the 79 included patients (males: 52; females: 27), 70 (88.61%) were > 6 years-old and 54 (68.35%) had atelectasis onset during winter. A majority experienced fever and cough. Among them, 44, 16, 21, 14, and 12 had normal/decreased white blood cells, elevated procalcitonin, abnormal hepatic function, abnormal myocardial enzyme spectrum, Mycoplasma pneumoniae infection, and Streptococcus pneumoniae infection, respectively. Seventy-nine patients presented different atelectasis degrees, including 16 and 29 with atelectasis in the right and left lung, respectively, while 34 had multiple consolidations and atelectasis lesions in both lungs. Fiberoptic bronchoscopy examination of 57 cases revealed mucus plug blockage in 6 cases; among them, 2 cases underwent bronchial cast removal. All patients received oseltamivir or peramivir for antiviral treatment and antibacterial treatment for complicated bacterial infection. All the patients recovered and were eventually discharged. Post-discharge follow-up showed that 77 cases were cured while 2 experienced recurrent respiratory tract infections and post-activity shortness of breath with chest computer tomography showing mosaic perfusion. Conclusion There is a high incidence of atelectasis caused by influenza A during winter among children aged < 6 years. The main manifestations are fever (mostly hyperpyrexia) and cough. Chest imaging shows consolidation and atelectasis occurring in any lung lobe. Some patients present multiple consolidations and atelectasis lesions complicated by mucus plugs or bronchial casts. Timely fiberoptic bronchoscopy and alveolar lavage could shorten the disease course and improve the prognosis.
Influence of the Knot Position on the Union of the Greater Trochanter after Bipolar Hip Arthroplasty via the Modified Dall Approach: A Prospective Non-Randomized Study
Authors: Kataoka Masanao , Fujita Hiroshi , Hara Hiroaki , Harada Hideto , Okutani Yuki , Murotani Yoshiki
Published: July 2020

Background: In our institute, all elderly patients with displaced femoral neck fracture were treated with cemented bipolar hemiarthroplasty (BHA) using the modified Dall approach. To our knowledge, there are no reports on the knot position of the greater trochanter reattachment. The aim of this study was to determine influence of two knot positions (anterior or posterior) on the complications of the greater trochanter.Methods: This is a prospective non-randomized study conducted on 95 elderly patients (95 hips) from September 2013 to December 2017. The knot position was changed from anterior to posterior alternately. The X-ray images obtained immediately after the operation were compared with those obtained at 3 months postoperatively; thereafter, the status of the greater trochanter was classified into three types: type A, no apparent shifting and fracture; type C, over 1-mm shifting of the fragment; and type F, fracture of the greater trochanter.Results: Regarding age at operation, sex, BMI, size of the greater trochanteric fragment, stem type, and surgeon, there was no significant difference between two groups. In the anterior group, 34 hips (72.3%), 5 hips (10.6%), and 8 hips (17.0%) were classified under type A, C, and F, respectively. In the posterior group, 44 hips (91.7%), 1 hip (2.1%), and 3 hips (6.3%) were classified under type A, C, and F, respectively. There were significantly fewer greater trochanteric complications in the posterior group. Conclusions: The posterior knot position improved the union of the greater trochanter after BHA compared with the anterior knot position.Trial registration: We have no trial registration but we had approved IRB at our hospital clinical research review committee. Retrospectively registered.
Auxora Versus Standard of Care for the Treatment of Severe or Critical COVID-19 Pneumonia: Results from a Randomized Controlled Trial
Authors: Miller Joseph , Bruen Charles , Schnaus Michael , Zhang Jeffrey , Ali Sadia , Lind April , Stoecker PharmD Zachary , Stauderman Kenneth , Hebbar Sudarshan
Published: July 2020

BACKGROUNDCalcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intravenously administered CRAC channel inhibitor, in adults with severe or critical COVID-19 pneumoniaMETHODSA randomized, controlled, open-label study of Auxora was conducted in adults with severe or critical COVID-19 pneumonia. Patients were randomized 2:1 to receive three doses of once-daily Auxora versus standard of care (SOC) alone. The primary objective was to assess safety and tolerability of Auxora. Additional outcomes included changes in clinical status based on an 8-point ordinal scale and the proportion of patients dying or requiring invasive mechanical ventilation in the 30 days after randomization.RESULTSIn total, 17 patients with severe and three with critical COVID-19 pneumonia were randomized to Auxora and nine with severe and one with critical COVID-19 pneumonia to SOC. Similar proportions of patients receiving Auxora and SOC experienced ≥1 adverse event (75% versus 80%, respectively). Fewer patients receiving Auxora experienced serious adverse events versus SOC (30% versus 50%, respectively). Two patients (10%) receiving Auxora and two (20%) receiving SOC died in the 30 days after randomization. Among patients with severe COVID-19 pneumonia, median time to recovery with Auxora was five days versus 12 days with SOC; recovery rate ratio was 1.87 (95%CI, 0.72, 4.89). Invasive mechanical ventilation was needed in 18% of patients with severe COVID-19 pneumonia receiving Auxora versus 50% receiving SOC (absolute risk reduction=32%; 95%CI, -0.07, 0.71). One intubation or death over 30 days would be prevented by treating 2.6 patients with Auxora. Outcomes measured by an 8-point ordinal scale were significantly improved for patients receiving Auxora, especially for patients with a baseline PaO2/FiO2=101-200.CONCLUSIONSAuxora demonstrated a favorable safety profile in patients with severe or critical COVID-19 pneumonia and improved outcomes in patients with severe COVID-19 pneumonia. The impact of Auxora on respiratory complications in patients with severe COVID-19 pneumonia will be further assessed in a planned randomized, blinded, placebo-controlled study.TRIAL REGISTRATIONClinicalTrials.gov,NCT04345614. Retrospectively registered 14April2020 - https://clinicaltrials.gov/ct2/show/NCT04345614
High prevalence of SARS-CoV-2 Infection Among Symptomatic Healthcare Workers in a large university tertiary hospital in São Paulo, Brazil
Authors: Buonafine Carolina Palamin , Paiatto Beatriz Nobre Monteiro , Leal Fabyano , Matos Samantha , Moraes Camila Ohomoto , Guerra Giovanna Guazzelli , Martuchelli Marcus Vinicius Vidal , Oliveira Danielle Leal , Durigon Edison Luiz , Soares Camila Pereira , Candido Erika Donizette , Telezynski Bruna Larotonda , Safadi Marco Aurelio , Almeida Flavia Jacqueline
Published: July 2020

Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 ( 9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male) and 2 (1.6%) died.Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.
CHANGES OF THE OPTICAL PROPERTIES OF TOP-GRADE FLOUR (SEMOLINA) FROM DURUM WHEAT DURING ITS RIPENING
Authors: Steinberg T. S. , Meleshkina E. P. , Shvedova O. G. , Morozova O. V. , Zhiltsova N. S.
Published: July 2020

Using the rapid method of digital image analysis by the developed scanning flour analyzer the optical properties of flour (semolina) obtained in laboratory and production conditions from durum wheat of three years of harvest (2017–2019), namely the «yellowness» indicator and the color characteristic in the blue part of the spectrum, were determined. The semolina color was also evaluated by the Konica Minolta CR-410 colorimeter. It is established that the «yellowness» indicator and the color characteristic in the blue part of the spectrum did not change within the first 5 to 6 days after grinding. The change of these indicators for all the samples is observed in the period from 6 to 20 days after grinding, there with the «yellowness» indicator decreased by 25 to 40 relative units, the color characteristic in the blue part of the spectrum increased on average by 133,75 relative units. Over the next three months, there was no change of color (by both indicators). In the course of experimental work the optical properties change depending upon carotenoids content of flour (semolina) during its ripening was shown. The correlation dependence between the «yellowness» indicator of flour (semolina) and its carotenoids content is characterized by a high approximation coefficient. The dependence of the color characteristic of flour in the blue part of the spectrum on the content of carotenoids is characterized by an approximation coefficient equal to 0.9358, and is described as a polynomial equation. It shows, that with a low carotenoid content, the considered indicator is higher by an average of 1100 relative units compared to the color of samples with a carotenoid content from 0.70 to 1.21 mcg/g. At that during storage the optical properties of flour variety with the lowest carotenoids content remained practically the same. During 78 days of storage, there was no significant change of color characteristics of the industrial flour samples, studied from the eleventh day after grinding — 5–8 times higher than the average repeatability of the measurement results.
Tools for formation and development of the environmentally friendly food products market: regional aspect in Ukraine
Authors: Dergachova Victoriia , Smerichevskyi Serhii , Kniazieva Tetiana , Smerichevska Svitlana
Published: July 2020

Utilization of modern technologies in food production causes several negative consequences having a long-term impact on public health due to the consumption of food containing components of inorganic origin. This circumstance requires the formation and development of the market of organic food in Ukraine. The paper aims to substantiate the possibility of using economic and organizational tools to rationalize environmentally friendly food consumption and eliminate their negative consequences for the region’s population. The study’s basis is the classical provisions of modern economic theory, environmental economics, and the concept of socio-ethical marketing. Based on the analysis of official statistics, the parameters and opportunities for the growth of the organic food products market in Ukraine by region are determined. The conformity of the product offer of ecologically clean products to different consumer segments in the region is revealed according to the criteria that characterize the groups of goods according to the degree of their ecological purity compared to the price parameter, frequency of purchase, and place of purchase. The priorities for the gradual expansion of the organic food market in the region have been determined with an emphasis on its expansion by attracting new consumer segments. The need for additional organizational measures in the region, aimed at both non-commercial and commercial promotion of healthy lifestyles and proper nutrition, is argued, which increases consumers’ involvement in these processes and increases awareness and interest in regular consumption of organic food.
Kajian Hutan Kota Malabar terhadap Kenyamanan Termal
Authors: Bado Towary Eduardo Hilario , Sulistyono Roedy , Tito Sama’ Iradat , Ferdian Muh. Agus
Published: July 2020

Comfort is something that humans need without exception when in a Green Open Space (RTH). Thermal comfort is a thermal condition felt by humans that is influenced by the environment. The existence of green space such as the City Forest of Malabar needs to be measured about it which can define its feasibility. (1) To examine the effect of thermal comfort in the Malabar forest on the community. (2) Analyzing vegetation in the Malabar city forest related to comfort. The results obtained in this study are the Temperature humidity index (THI) of respondents in the Malabar city forest known to average values of 22.42. It can be categorized that the Malabar city forest has a comfortable condition because in the index range 21 to 24. The analysis of the vegetation analysis in the Malabar city forest is concluded for the predominant vegetation sapling level, ie the pole glodokan plant with an important value index of 6.69. Whereas the pole level that dominates is mahogany with an important value index of 6.66. As for the tree level, the dominant vegetation types are plants with an important value index of 127.91
An accomplished procedure of horseradish peroxidase immobilization for removal of acid yellow 11 in aqueous solutions
Authors: Altikatoglu Yapaoz Melda , Attar Azade
Published: July 2020

Horseradish peroxidase (HRP) characteristics were improved by two techniques, Na-alginate entrapment and glutaraldehyde crosslinking prior to alginate entrapment, in order to enhance the stability, functionality and removal of dyes in waste water. Free, entrapped and crosslinked-entrapped enzymes were compared by activity assays, which indicated the optimum temperature is 25 °C and pH 4.0–5.0. Kinetics results showed that alginate entrapment and crosslinking prior to entrapment increased Vmax and did not cause any significant decrease in Km. The thermal resistance of the free enzyme was short-term, zero residual activity after 250 min, while the immobilized enzymes preserved more than 50% of their activity for 5 h at 60 °C. Immobilized HRP was resistant to methanol, ethanol, DMSO and THF. The storage stability of free HRP ended in 35 days whereas entrapped and crosslinked-entrapped HRPs had 87 and 92% residual activity at the 60th day, respectively. HRP was used in the decolorization of azo dye Acid yellow 11 and total decolorization (>99%) was obtained using crosslinked-entrapped HRP. Reusability studies presented the improvement that crosslinked-entrapped HRP reached 74% decolorization after 10 batches. The results demonstrated that the novel immobilized HRP can be used as an effective catalyst for dye degradation of industrial waste effluents.
Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling
Authors: Borah Pobitra , Hazarika Sangeeta , Deka Satyendra , Venugopala Katharigatta N. , Nair Anroop B. , Attimarad Mahesh , Sreeharsha Nagaraja , Mailavaram Raghu P.
Published: July 2020

The successful conversion of natural products (NPs) into lead compounds and novel pharmacophores has emboldened the researchers to harness the drug discovery process with a lot more enthusiasm. However, forfeit of bioactive NPs resulting from an overabundance of metabolites and their wide dynamic range have created the bottleneck in NP researches. Similarly, the existence of multidimensional challenges, including the evaluation of pharmacokinetics, pharmacodynamics, and safety parameters, has been a concerning issue. Advancement of technology has brought the evolution of traditional natural product researches into the computer-based assessment exhibiting pretentious remarks about their efficiency in drug discovery. The early attention to the quality of the NPs may reduce the attrition rate of drug candidates by parallel assessment of ADMET profiling. This article reviews the status, challenges, opportunities, and integration of advanced technologies in natural product research. Indeed, emphasis will be laid on the current and futuristic direction towards the application of newer technologies in early-stage ADMET profiling of bioactive moieties from the natural sources. It can be expected that combinatorial approaches in ADMET profiling will fortify the natural product-based drug discovery in the near future.
The Potency of Catechin from Gambir (Uncaria gambir Roxb.) as a Natural Inhibitor of MurA (1UAE) Enzyme: In vitro and In silico studies
Authors: Riyana Bella , Huspa Desi Harneti Putri , Satari Mieke Hemiawati , Kurnia Dikdik
Published: July 2020

Background:

Currently, infectious diseases caused by pathogenic and resistant bacteria
are more challenging for anti-bacterial drug discovery. The discovery of new anti-bacterial agents
developed in many mechanisms includes disruption of the bacterial cell wall formations. The MurA
is a key enzyme contributing to the first step of bacterial peptidoglycan biosynthesis and is, therefore,
proposed as an effective bactericidal target.

Objective:

The purpose of this research is to identify anti-bacterial compounds from U. gambir
Roxb and to predict the potential inhibitory activities against murA enzyme by in silico study.

Materials and Methods:

Investigation and discovery of new inhibitors of MurA enzyme were conducted
on the medicinal plant of Gambir (Uncaria gambir Roxb) and those that reportedly contained
anti-bacterial agents. The anti-bacterial compounds were isolated by combinations of chromatography
methods guided by anti-bacterial activity against bacteria of E. faecalis, S. mutans, and S.
sanguinis. The structures of active compounds were characterized by spectroscopic methods, and
the anti-bacterial activity was evaluated by the microdilution method (in vitro) combined with molecular
docking of the MurA enzyme (in silico).

Results:

The anti-bacterial flavonoids of catechin were isolated from U. gambir Roxb with MIC
values of 6250 and 12500 ppm, respectively, against S. sanguinis and E. faecalis. The in silico study
showed that catechin has a binding affinity of -8.5 Kcal/mol to MurA which is higher than fosfomycin
as a positive control.

Conclusions:

The catechin is predicted to have potential as a new natural inhibitor of the MurA enzyme
to inhibit bacterial cell wall biosynthesis.
Design and Synthesis of Novel Coumarin Conjugated Acetamides as Promising Anticancer Agents: An In Silico and In Vitro Approach
Authors: Mamatha S.V. , Belagali Shiddappa L. , Bhat Mahesh , Kumbar Vijay M.
Published: July 2020

Background:

Coumarin and benzophenone possess a vast sphere of biological activities whereas thiazoles
display various pharmacological properties. Hence we focused on incorporation of coumarin and thiazole core to the
benzophenone skeleton to enhance the bioactivity anticipating their interesting biological properties.

Objective:

The objective of the current work is synthesis and biological evaluation of a novel series of coumarin fused
thiazole derivatives.

Methods:

A novel series of Coumarin conjugated thiazolyl acetamide hybrid derivatives were synthesized by multistep
reaction sequence and were characterized by the FT-IR, LCMS and NMR spectral techniques. The newly synthesized
compounds were screened for anticancer activity by in-silico and in-vitro methods. The cytotoxicity of the synthesized
unique compounds had been executed for two different cancer cell lines MCF-7 (Breast cancer) and KB (Oral cancer) in
comparison with standard paclitaxel by MTT assay.

Results:

The compound 7f is a potent motif with an acceptable range of IC50 values, for anti-cancer activity, i.e.,
63.54μg/ml and 55.67μg/ml, against the MCF-7 and KB cell lines, respectively. Molecule docking model revealed
that this compound formed three conventional hydrogen bonds with the active sites of the amino acids,
MET 769, ARG 817, and LYS 721.

Conclusion:

Compound 7f with two methyl groups on the phenoxy ring and one 4-position methoxy group on the benzoyl
ring, showed a significant cytotoxic effect. An advantageous level of low toxicity against normal cell line (L292) by MTT
assay was determined.
Anti-allergy Effect of Sulfated Polysaccharide from Sargassum polycystum on Dinitrofluorobenzene Induced Allergic Contact Dermatitis in Mice
Authors: Dela Cruz Sharmaine Y. , Vasquez Ross D. , Salonga Reginald B. , Corpuz Mary Jho-Anne T.
Published: July 2020

Background:

Sargassum polycystum C. Agardh has potent antioxidant and antiinflammatory
properties. However, its anti-allergic effect has not yet been reported. In this study, we
investigated the anti-allergic effects of sulfated polysaccharide of S. polycystum (SPSP) in Dinitrofluorobenzene
(DNFB)- induced allergic contact dermatitis animal model.

Methods:

SPSP was extracted through the hot water extraction method and was subjected to compositional
analyses. For the Allergic Contact Dermatitis (ACD) model, symptoms were induced by the
topical application of 0.5% DNFB on the shaved ventral skin of mice. SPSP (500, 1000, and 2000
mg/kg) and Prednisolone were orally administered for seven days after sensitization. Elicitation was
performed seven days later with 0.2% DNFB. After this, ear thickness was measured at baseline and
24 hours post elicitation using a dial thickness gauge. Serum of mice was obtained 24 hours post
elicitation, and the level of IFNγ and TNFα was quantified by enzyme-linked immunosorbent assays
(ELISA).

Results:

SPSP afforded 33.6% carbohydrates, 23.7% sulfate, 7.5% protein, and 1.5% uronic acid
contents. SPSP inhibited the ear swelling and cytokines (IFNγ and TNFα) production in DNFBinduced
mice in a dose-dependent manner. In comparison with Prednisolone (p>0.05), the highest
concentration (2000 mg/kg) of SPSP showed a comparable anti-allergic effect.

Conclusion:

These findings showed that the sulfated polysaccharide from S. polycystum is a potential
natural source to treat allergic contact dermatitis. The effect is attributed to the polysaccharideprotein
complex present in the extract, but further studies are needed to establish the exact mechanism
of action of SPSP in the treatment of the disease.
High Anti-cancer Activity, Low Animal Toxicity, and Structure Activity Relationships of Curcumin Analogs
Authors: Song Sen-Chuan , Mai Yu-Liang , Shi Hua-Hong , Liao Bing , Wang Fei
Published: July 2020

Background:

Inhibition of cancer cell growth and low in vivo toxicity are two important
criteria for the development of anti-cancer drugs. Curcumin is a promising candidate for developing
novel anti-cancer drug analogs. The research group designed the 3,5-bis-(3,4,5-
trimethoxybenzylidene)-1-methyl-piperidin-4-one analog of curcumin that significantly inhibited
the growth of esophageal cancer cells in vivo. In this study, 81 curcumin analogs were synthesized,
analyzed both in vitro and in vivo, and their structure activity relationships (SARs) were determined.

Methods:

Based on the parent structure of curcumin, 81 analogs of 3,5-bis(substitutedbenzylidene)-
piperidin-4-one compounds were designed and synthesized. Their anti-cancer activity in the human
cancer cell lines was evaluated using the MTT assay, and in vivo toxicity was evaluated in mice.
The SARs of selected compounds were analyzed.

Results and Discussion:

Among the designed curcumin analogs, 61 compounds exerted anti-cancer
effects higher than the parent compound in vitro; 23 compounds inhibited cell growth in the human
cancer cell line at low concentrations (IC50 values below 1 μM). The acute toxicity of curcumin
analogs was tested in mice; 13 compounds were selected, which did not show any obvious toxicity
at doses as high as 25.0 mg/kg. The SARs of these shortlisted curcumin analogs were determined.

Conclusion:

Twenty-three curcumin analogs exhibiting promising in vitro anti-cancer activity and
low in vivo toxicity were designed. SAR analysis indicated the optimal functional groups in the
molecule required for anti-cancer activity. This study not only suggested a useful strategy to design
curcumin analogs for the development of anti-cancer drugs, but also revealed a group of curcumin
analogs which could be further explored.
Методы атомно-силовой микроскопии для исследования суперпротонных кристаллов
Authors: Гайнутдинов Р.В. , Толстихина А.Л. , Селезнева Е.В. , Макарова И.П.
Published: July 2020

Complex studies of new superprotonic crystals - acidic salts of potassium – ammonium sulfate (K1-x(NH4)x)3H(SO4)2, x ≥ 0.57 were carried out. Data on surface morphology, domain structure and conductivity of samples were obtained using atomic force microscopy. For the first time, the stability and degradation of the surface of superprotonic crystals were studied at the nanoscale. Based on piezoelectric response microscopy data, it was found that when the temperature decreased from 296 to 282 K, the (K0.43(NH4)0.57)3H(SO4)2 crystal transits from the paraelectric phase to the ferroelectric one.
Возможности метода ВИМС для анализа профиля имплантированного водорода в кремнии и примесного состава структур "кремний на изоляторе"
Authors: Абросимова Н.Д. , Дроздов М.Н. , Оболенский С.В.
Published: July 2020

Abstract The paper deals with the theoretical and experimental study resultsof implanted hydrogen distribution in silicon and SiO2-Si structures for SOI created by hydrogen transfer technology. A measurement technique for the quantitative analysis of implanted hydrogen in silicon high concentrations by the SIMS method is proposed, including the hydrogen atoms concentration quantitative calibration and the analysis depth normalization from the sputtering time. The implanted hydrogen in silicon and SiSiO2 structures depth distribution studies results are presented. The impurity composition of the implanted structures was determined. The lateral homogeneity and temporary stability of the implanted structures were also controlled.
Многомасштабный анализ ритмических процессов с меняющимися во времени характеристиками
Authors: Куприяшкина Н.М. , Павлова О.Н. , Павлов А.Н.
Published: July 2020

The problem of diagnosing structural changes in non-stationary processes in the case of the dependence of the degree of non-stationary on the frequency range is considered. Using the dynamics of slow sleep waves as an example, a multiscale analysis of experimental data is carried out and the possibility of improving the quality of diagnostics by choosing an appropriate basis for wavelet functions is discussed.
Нековалентные взаимодействия подскорлуповой яичной мембраны
Authors: Иванов-Омский В.И. , Ястребов С.Г.
Published: July 2020

The spectrum of non-covalent interactions active in the infrared region for the membrane of the eggshell was studied. The energies of these interactions are estimated. We compare results with the data previously obtained for various samples of the human aortic valve and conclude on prospects of usage of the subshell egg membrane as a substitution for the basal layer of the aortic valve for in vitro experiments.
Нарушение эффекта Кайзера при нагружении эвтектических сплавов сиcтемы Pb-Sn
Authors: Салита Д.С. , Поляков В.В.
Published: July 2020

This paper investigates acoustic emission under mechanical loading of Pb-Sn alloys. It is revealed that the Kaiser effect under repeated loading is not observed when certain concentrations of constituents lead to establishment of eutectic structures. The absence of acoustic emission memory effect in eutectic Pb alloys is explained. The proposed explanation is based on peculiar features of plastic flow caused by the motion of eutectic alpha- and beta-phase colonies at the joint interfaces.
Reviewing Identification and Intervention of School Bullying on Perception of Middle School Counselling Teacher on Dealing Bullying
Authors: Endriyani Lia , Santoso Nindita Kumalawati
Published: July 2020

Bullying behavior is serious problem that can affect mental and psychosocial development in both the bully and the victim. School bullying happens in school aged children and occurs during or after school hours. As bullying happened in schools, counseling teacher is one of main resource in efforts to prevent and to intervene bullying situations. Counseling teacher has competencies and authorities regarding this matter. This study aimed to know perception of counseling teacher on dealing with bullying by reviewing information about identification and intervention of school bullying. This study was quasy experiment with one group pre-test and post-test design. Purposive sampling was used to obtain 16 middle school counseling teachers in Kasihan and Pajangan sub district as participants to join this study. The data were collected through modification of Perceptions of Bullying Questionnaire and The Handling Bullying Questionnaire. Data were analyzed by Paired t-test. Majority of respondents were more than 46 years with the highest level of education was bachelor degree. Counseling teacher had experience as counselling teacher for more than 10 years. Teacher’s perceived ability to identify the bully and the victim was in “enough” category. Perceived method to deal with the bully was involving students and their parents while method to deal with the victim was involving students, parents and school personnel. There are significant differences of teacher’s perception on handling bullying before and after intervention (p- value=0.032). Giving information can give a positive effect against the perception the guidance counselor in dealing with bullying.
Frecuencia y altura de corte sobre la calidad del Megathyrsus maximus (cv. Gatton panic)
Authors: Schnellmann Leandro Pablo , Verdoljak Juan José Oscar , Bernadis Aldo , Martínez-Gonzalez Juan Carlos , Castillo-Rod´ríguez Sonia Patricia , Limas-Martínez Andrés Gilberto
Published: July 2020

El estudio que se presenta a continuación tuvo como objetivo evaluar la frecuencia e intensidad de la calidad nutricional en la materia seca (MS) del pasto Megathyrsus maximus (cv. Gatton panic), y fue desarrollado en la Cabaña Doña Anita, provincia del Chaco, Argentina. Se empleó un diseño completamente al azar con un arreglo factorial de 2 alturas de corte (A = 0,15 y 0,30 m), 3 frecuencias (F = 30, 45 y 90 días) y 2 tiempos (T = 90 y 180 días) con cinco repeticiones para cada uno (60 unidades experimentales). Se determinó el porcentaje de MS, proteína bruta (PB), fibra detergente ácido (FDA), fibra detergente neutra (FDN) y digestibilidad (DI). En el caso de la PB, se encontró una interacción entre las variables A x T y F x T. Para la interacción T x A, los cortes realizados en menor tiempo presentaron diferencia significativa (p < 0,05) en las dos alturas. Para la interacción T x F en la combinación 90 x 30, hay diferencia significativa (p < 0,05) respecto a las restantes combinaciones. Respecto a la FDN, para la variable altura, el contenido de esta se incrementa al aumentar aquella (p < 0,05) debido a un mayor alargamiento de tallos y hojas. En cuanto a la FDA se observaron diferencias (p < 0,05) entre los valores para la interacción T x A para 180 días con 0,15 y 0,30 m. Para la digestibilidad, se encontraron las diferencias significativas (p < 0,05) en la interacción de T x A. Se concluye que el mayor contenido de proteína bruta se obtuvo con la frecuencia de 30 días. La FDN y la FDA aumentaron con el mayor tiempo y la altura de la pastura.
Notes From the Field: Use of Emergency Medical Service Data to Augment COVID-19 Public Health Surveillance in Montgomery County, Maryland, From March to June 2020
Authors: Sayers David R , Hulse Scott T , Webber Bryant J , Burns Timothy A , Denicoff Anne L
Published: July 2020

Epidemiologic and syndromic surveillance metrics traditionally used by public health departments can be enhanced to better predict hospitalization for coronavirus disease (COVID-19). In Montgomery County, Maryland, measurements of oxygen saturation (SpO2) by pulse oximetry obtained by the emergency medical service (EMS) were added to these traditional metrics to enhance the public health picture for decision makers. During a 78-day period, the rolling 7-day average of the percentage of EMS patients with SpO2 <94% had a stronger correlation with next-day hospital bed occupancy (Spearman ρ=0.58, 95% CI 0.40-0.71) than either the rolling 7-day average of the percentage of positive tests (ρ=0.55, 95% CI: 0.37-0.69) or the rolling 7-day average of the percentage of emergency department visits for COVID-19–like illness (ρ=0.49, 95% CI: 0.30-0.64). Health departments should consider adding EMS data to augment COVID-19 surveillance and thus improve resource allocation.
Tracking Exposure to Ads Amid the COVID-19 Pandemic: Development of a Public Google Ads Data Set (Preprint)
Authors: Al Tamime Reham , Weber Ingmar
Published: July 2020

BACKGROUND

The COVID-19 pandemic has had a substantial impact on economies, governments, businesses, and most importantly, people’s health. To bring the spread of COVID-19 under control, strict lockdown measures have been implemented across the globe. These lockdown measures resulted in a spate of panic buying and increase in demand for hygiene products and other grocery items.

OBJECTIVE

In this paper, we describe a data set from Google Ads that looks at the presentation of ads to people while they browse the web during the COVID-19 pandemic. We are making the data set available to the research community.

METHODS

We started this ongoing data collection on March 28, 2020, leveraging Developer Tools’ network requests to retrieve Google Ads data. We identified a list of items related and unrelated to panic buying. We then captured these items as targeting criteria under what people are actively researching or planning on Google Ads. Google Ads data has been filtered using additional targeting criteria such as country, gender, and parental status.

RESULTS

Since the inception of our collection, we have actively maintained and updated our repository on a monthly basis. In total, we have published over 4116 data points. This paper also presents basic statistics that reveal variations in Google Ads data across countries, gender, and parental status.

CONCLUSIONS

We hope that this Google Ads data set can increase our understanding of ad exposure during the COVID-19 outbreak. In particular, this data set can lead to further studies that look at the relationship between exposure to ads, time spent web browsing, and health outcomes.
Adapting an Outpatient Psychiatric Clinic to Telehealth During the COVID-19 Pandemic: A Practice Perspective (Preprint)
Authors: Sasangohar Farzan , Bradshaw Major R , Carlson Marianne Millen , Flack James N , Fowler James C , Freeland Diana , Head John , Marder Kate , Orme William , Weinstein Benjamin , Kolman Jacob M , Kash Bita , Madan Alok
Published: July 2020

UNSTRUCTURED

As the demand for telepsychiatry increases during the COVID-19 pandemic, the strengths and challenges of telepsychiatry implementation must be articulated to improve clinical practices in the long term. Currently, observations within US contexts are lacking; therefore, we report on the rapid implementation of telepsychiatry and workflow experiences in a psychiatric practice based within a large health care system in southeast Texas with a national catchment area. We discuss the logistics of the implementation, including modes of communication, scheduling, coordination, and capacity; the psychological effects of web-based services, including both the loss of the physical therapeutic environment and the unique interpersonal dynamics experienced in the virtual environment; and postadoption patterns of engagement with our services and with other clinical functions affected by the rapid adaptation to telemedicine. Our art therapy group programming serves as an applied case study, demonstrating the value of a well-managed web-based program (eg, patients were receptive and well-engaged, and they appreciated the continuity of accessible service) as well as the challenges (eg, the need for backup plans and technological fallbacks, managing interruptions and telecommunication learning curves, and working around the difference in resources for art and music therapy between a well-stocked clinical setting versus clients’ home spaces). We conclude from our experience that the overall strengths of telepsychiatry include receptive and well-engaged responses from patients as well as the expansion of boundaries, which provides a directly contextualized view into patients’ home lives. Challenges and corresponding recommendations include the need for more careful safety planning for high-risk patients; maintaining professional boundaries in the newly informal virtual setting; designing the physical space to both frame the patient encounter and maintain work-life balance for the therapist; allowing for delays and interruptions (including an initial acclimation session); and preserving interprofessional care team collaboration when the physical locations that normally facilitate such encounters are not accessible. We believe that careful observations of the strengths and challenges of telepsychiatry during this pandemic will better inform practices that are considering telepsychiatry adoption both within pandemic contexts and more broadly thereafter.
Antioxidant and Antimicrobial Activities of Methanolic Leaves Extract of Lagerstroemia parviflora
Authors: Bharadwaj Namita , Chaturvedi Anjna
Published: July 2020

An antioxidant is a molecule capable of terminating the chain reactions that damage cells by removing free radical intermediates and inhibit other oxidation reactions by thereby reducing stress responsible for many degenerative disorders. The present study was concerned with phytochemical screening, antioxidant, antimicrobial activities of methanolic leaves extract of Lagerstroemia parviflora. It was observed that the methanol extract showed IC 50 value of 76.05µg/ml as compare to standard ascorbic acid 14.66 µg/ml. It was evident that the extracts showed proton-donating ability and this could serve as free radical inhibitors or scavengers, acting possibly as primary antioxidants. Thus the methanol extract of this plant possesses the strongest ability to scavenge DPPH radical. The leaves extracts of Lagerstroemia parviflora exhibited potential antibacterial activity against Staphylococcus aureus (20±0.2, 21±0.1 and 23±0.1), Salmonella bongori (9±0.3, 12±0.1and 15±0.5) and Aspergillus niger (7±0.1, 9±0.1 and 11±0.2) at the concentration level of 25-100mg/ml. The Results of antimicrobial activity of extract showd more effectiveness against both the selected bacteria (Staphylococcus aureus and Salmonella bongori) found less effective against fungus (Aspergillus niger). The present study suggests that the use of leaves of this plant may be exploited for health supplements and has potential for topical treatment.

Keywords: Lagerstroemia parviflora, Antioxidant, Antimicrobial
AN OVERVIEW ON PHARMACOPOEIAS IN THE WORLD AND MONOGRAPH ELABORATION TECHNIQUES
Authors: YAPAR Evren ALGIN , ÖZDEMİRHAN Mehmet Emre
Published: July 2020

Pharmacopoeias are official sources that contain national and international rules that must be complied with legally and scientifically regarding substances, materials, drugs, devices and methods used in pharmaceutical field and pharmaceutical production. The monographs are consisted of general titles such as definition, production, characters, identification, tests, assay, storage, labelling and impurities. The World Health Organization states that sixtyeight different pharmacopoeia continue to be used effectively in fifty six countries around the world. In this review information about national and international wold pharmacopoeias, structure and general content of pharmacopoeias, and monograph elaboration techniques are given.
Peer Review History:
Received 26 April 2020; Revised 25 May; Accepted 3 July, Available online 15 July 2020
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Received file

Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 8.0/10
Reviewer(s) detail:
Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab
Affiliation: Umm Al-Qura University;  Makkah Al-Mukarramah, Saudi Arabia
E-mail: maabourehab@uqu.edu.sa
 
Name: Heba M. Abd-El-Azim
Affiliation: Faculty of Pharmacy – Damanhour University
E-mail: h_m_abdelazim@hotmail.com
 
Comments of reviewer(s):
TANTANGAN PEMERINTAH ACEH DALAM MENGIMPLEMENTASI UNDANG-UNDANG PEMERINTAH ACEH (UUPA)
Authors: Januar Eka , Marziah Ainol
Published: July 2020

Prolonged conflict between the Free Aceh Movement (GAM) and the Indonesian government from 1976, until finally a settlement took place on 15 August 2005 in Helsinki, Finland, under the mediator Martti Ahtisaari (former President of Finland) both GAM-RI parties sat together to determine their position to end all causes of conflict in Aceh. In the points of the agreement of the Memorandum of Understanding (Helsinki MoU), Aceh was given special rights by the Government of Indonesia to administer Self Government. In the Helsinki MoU article 1 paragraph 1.1.2 a, b, c, d which plays a role in implementing the Law on the Governing of Aceh, but the reality that happened has not been as agreed upon in the MoU. The Aceh Government Law No 11 of 2006 which regulates the Aceh provincial government is further explained in the form of Qanun which was born by the Aceh Government. As a substitute for the Special Autonomy Law and the results of the peace agreement, Aceh is given special authority to regulate and manage government in accordance with the regulations of the Government of Aceh. The methodology of the research used is qualitative research with descriptive type. Searching for and analyzing data through interviews, observations and documents. This study used the theory of Power Balance. The Power Balance system provides various alternatives for policy makers, which leads to war or negotiations. The results of the research obtained are the factors that hampered the implementation of the UUPA, namely: aspects of the legal foundation, lack of cohesiveness of government in Aceh, the existence of internal and external factors, and different perceptions in understanding the Aceh Government Law
POLITIK DINASTI DI ACEH; STUDI KEPEMIMPINAN AMPON BANG DI KABUPATEN NAGAN RAYA
Authors: Aklima Aklima , Ramadhan Ilham
Published: July 2020

The focus of  study the political dinasti strategic Ampon Bang of Nagan Raya distric. The aim of reseach to find out the political strategic that strengthens the couse of the political dynasty Ampon Bang aplicatin in Nagan Raya distric.The methodology used is qualitatif methode collecting data throughdocumentation and in dept interview technic. The Result of the research obtained political dynasty leadershipAmpon Bang Usingthe concept of the families with the political strategic carried out; first, leadership organisation structure is filled by family and relatives. Second, close the space for public partisipation.