bluuebunny/crossref_metadata_2025 huggingface dataset:
COMMUNITY-BASED PARTICIPATORY RESEARCH TO IMPROVE ALUMNI TRANSITION FROM AN INTENSIVE RESEARCH TRAINING PROGRAM FOR HISTORICALLY UNDERREPRESENTED UNDERGRADUATES
Authors: Raymaker Dora M. , Scharer Mirah , Miller Rebecca , Widmer Ashley , Posadas Dhale Larsen , Keller Thomas E.
Published: December 2022

Various initiatives for undergraduates from historically underrepresented backgrounds attempt to address disparities in the completion of science, technology, engineering, and mathematics (STEM) degrees and the pursuit of careers in scientific research. Intensive research training programs for historically underrepresented undergraduates may include multiple components, such as authentic research experiences, advising and mentoring, supplemental curriculum, and financial assistance. Following comprshensive support during program participation, the postprogram transition may present a vulnerable period in students' career trajectories. This study used a community-based participatory research (CBPR) approach to investigate the experiences of students completing an intensive research training program to understand and develop recommendations for the postprogram transition process. As a team of program alumni, academic researchers, and program staff, we developed, conducted, and analyzed semistructured, open-ended interviews of recent program alumni and students approaching program completion (n = 11; 55% female, 55% non-White). Applying thematic analysis at semantic and latent levels through a critical paradigm revealed the transition as a bittersweet experience, with feelings of pride and accomplishment mixed with sadness and anxiety. Findings also suggested the transition is described as a narrative influenced by preceding program experiences and adaptations. Financial concerns were prominent, and specific barriers and facilitators of successful transition included aligned mentoring, negotiation of continued research employment, consideration of culture, planning for next steps, and engagement with the scholar community. Collaboratively, we developed recommendations for program improvements potentially relevant to similarly intensive STEM diversity programs. We also highlight the value of a CBPR approach that includes students equitably as coresearchers in program research and evaluation.
Illusio der Autonomie: Carolin Amlingers Studie über literarische Arbeit
Authors: Jakob Rafael
Published: December 2022

Carolin Amlinger's Schreiben. Eine Soziologie literarischer Arbeit is a large-scale, but still coherent analysis of contemporary literary production in Germany. Inspired by Pierre Bourdieu's field theory, trained in critical theory, and based on interviews with authors she interpreted using qualitative methods, Amlinger combines three approaches: a history of the (West) German literary market and the development of the literary public sphere from 1871 to the recent present, an account of institutions in the present-day German literary scene, and an analysis of the habitus of contemporary authors. Amlinger shows how literary work today is characterized by a blurring of the boundaries between market and public. According to her observation, this development goes hand in hand with an essentialization of authorship – an understanding that justifies precarious work with the promise of creative self-realization. As the review argues, this results in an analytical balancing act: on the one hand, to show how literary writing and the notion of it are reshaped, and at the same time to remain sensitive to the resistance of literary practices and to concepts of authorship that oppose a neoliberal notion of labor. Amlinger's refraining from complementing authors' self-conceptions with observations of actual practices and the products of literary labor make it difficult for the study to consistently pursue both perspectives.
Regular and polyregular theories of reduplication
Authors: Rawski Jonathan , Dolatian Hossep , Heinz Jeffrey , Raimy Eric
Published: December 2022

We explore the generative capacity of morphological theories of reduplication. We computationally classify theories of reduplication using a hierarchy of string-to-string function classes. Reduplication as a process requires only the regular class of functions. We show that various morphological theories necessarily treat it as a more expressive polyregular function, while others maintain regularity. We discuss the significance of this formal result for reduplicative functions and recognition.
The effects of diabetes knowledge, self-efficacy, and depression on self-management in older patients with diabetes in the community: A cross-sectional study
Authors: Park Hyeok Gyu , Kwon Myoung Jin
Published: December 2022

Purpose: The purpose of this study was to identify factors related to self-management of older patients with diabetes. Methods: The subjects of the study were 255 older patients with diabetes registered at the public health center in C-do O-gun. Data were analyzed with IBM SPSS ver. 24.0. Results: The self-management had significant positive correlations with diabetes knowledge (r=.29, p<.001) and self-efficacy (r=.62, p<.001), and had a significant negative correlation with depression (r=-.47, p<.001). A hierarchical multiple regression was conducted to analyze the factors effecting self-management. In the Model II, subjects with religion (β=.10, p=.033), subjects of higher than middle school graduate (β=.12, p=.036), subjects with one comorbidity (β=.16, p=.034), diabetes knowledge (β=.12, p=.017), self-efficacy (β=.49, p<.001), and depression (β=-.27, p<.001) had significant effects on self-management, and the explanatory power increased to 48.7% (F=22.88, p<.001). Conclusion: To improve the self-management of older patients with diabetes, not only sufficient diabetes knowledge should be provided through systematic education, but also development of the self-management program that improves self-efficacy and includes psychological support for the prevention and mitigation of depression is required.
Reflections of Intrusion and Intrinsic Motivation on Organizational Citizenship Behavior: The Mediator Role of Relational Energy
Authors: ÖZKAN Osman , ÜZÜM Burcu , AKSOY KÜRÜ Seval
Published: December 2022

The aim of this research, which is based on the conservation of resources theory, is to determine to what extent relational energy mediates the effect of intrusion and intrinsic motivation on the additional role behaviors of employees. The sample of the research consists of 228 health sector employees reached in Zonguldak province between November 2021 and January 2022 by convenience sampling method. The questionnaire technique was used as a data collection tool in the research, and the prepared questionnaire was applied to the same people in two different time periods. As a result of the analyzes, it has been observed that the intrusion has a negative effect on organizational citizenship behavior while intrinsic motivation has a positive impact. Also, it has been determined that the intrusion through relational energy fully mediates while intrinsic motivation partially does. The results contribute to the literature and give ideas to researchers.
COVID-19 Pandemisinden Algılanan Ciddiyet Düzeyinin Boş Zaman Faaliyetlerine Katılım, Algılanan Boş Zaman Memnuniyeti ve Öznel İyi Oluş Üzerindeki Koşullu Etkilerinin Tespiti
Authors: AVCILAR Mutlu Yüksel , AÇAR Mehmet Fatih , KARACA Bahar
Published: December 2022

Bu çalışmanın amacı, bireylerin boş zaman faaliyetlerine katılım düzeylerinin, boş zaman faaliyetlerinden algılanan memnuniyet aracılığıyla öznel iyi oluşlarına etkisinin ve bu ilişkilerde COVID-19’dan algılanan ciddiyet düzeyinin düzenleyici rolünün incelenmesidir. Analiz için gerekli olan veriler, kolayda örnekleme yöntemi ile Türkiye’nin çeşitli illerinde çalışan 405 bireyden çevrimiçi anket yöntemi ile elde edilmiştir. Araştırma kapsamında geliştirilen hipotezler regresyon analizi, aracı etki analizi ve koşullu süreç analiziyle test edilmiştir. Aracı etki analizi sonucuna göre, boş zaman faaliyetlerinden algılanan memnuniyet değişkeninin aracı rolü tespit edilmiştir. Koşullu etki analizi sonucunda ise COVID-19’dan algılanan ciddiyet düzeyinin araştırmanın kavramsal modelinde yer alan değişkenler arasındaki doğrudan ve dolaylı ilişkiler üzerinde koşullu etkisinin bulunduğu belirlenmiştir.
Çevresel, Sosyal ve Kurumsal Yönetim (ESG) Performansının Piyasa Değeri Üzerindeki Etkisi: Firma Büyüklüğünün Rolü
Authors: KULALI Gülşah
Published: December 2022

Çalışmada gelişmekte olan piyasalardan Borsa İstanbul’da (BIST) işlem gören işletmelerin çevresel, sosyal ve kurumsal yönetim (ESG) kriterleri konusundaki performanslarının piyasa değeri ile ilişkisi ve bu ilişkide firma büyüklüğünün rolü araştırılmaktadır. Ohlson (1995) değerleme modelini temel alan genişletilmiş statik doğrusal panel regresyon modeli tahminlerinden izleyen sonuçlar elde edilmiştir. Firma büyüklüğü, ESG kriterlerinin piyasa değeri üzerindeki etkileri bakımından firmalar arası farklılıkları açıklamada önemli bir role sahiptir. Firma büyüklüğünün etkisi altında hem ESG kriterlerinin hem de E, S ve G bileşenlerinin ayrı ayrı her birinin piyasa değeri üzerinde anlamlı pozitif etkisi vardır. Görece daha büyük şirketlerde pozitif etkilerin daha büyük olduğu görülmektedir.
ADOLESAN BİREYLERDE İSKELETSEL VE DENTAL GELİŞİMİN OBEZİTE İLE İLİŞKİSİ
Authors: GEÇGELEN Mine , UZUN Mustafa
Published: December 2022

Amaç

Bu çalışmada obez ve normal kilolu bireylerin kraniyofasiyal

gelişim, dental yaş ve servikal vertebra maturasyonu

(CVM) açısından büyüme ve gelişimlerinin

karşılaştırılması amaçlanmıştır.

Gereç ve Yöntem

Ortodontik tedavi için kliniğe başvuran 12-16 yaş aralığındaki

hastalardan vücut kitle indeksi persentil değeri

≥%95 olan 51 obez (31 kız, 20 erkek) hasta ile

persentil değeri %16-85 olan 52 normal kilolu (32 kız,

20 erkek) hasta çalışmaya dahil edildi. Tedavi başında

alınan sefalometrik ve panoramik radyografilerden

bireylerin kraniyofasiyal gelişimi, servikal vertebra

maturasyonu ve dental yaşı değerlendirildi. Parametrik

varsayımlar sağlanmadığı için gruplar arası karşılaştırmada

Mann-Whitney U testi kullanıldı.

Bulgular

Kızların SNA, SNB, Y aksı açısı ve Pm-A değerlerine

ait ortalamalar gruplar arasında istatistiksel olarak

anlamlı farklar göstermiştir (p
Análisis de desempeño de las organizaciones económicas rurales
Authors: Martínez López Anabel , Muñoz Rodríguez Manrrubio , Santoyo Cortés Vinicio Horacio
Published: December 2022

El desempeño organizacional ha sido abordado desde distintas perspectivas; posee múltiples componentes o dimensiones que lo integran, y la elección de estos componentes dependerá del tipo e intereses de la organización que evaluar. Los estudios disponibles en México sobre desempeño de las organizaciones económicas en el medio rural solo ofrecen un balance general del estado financiero de estas, mas no reflejan el valor que reciben los socios por permanecer organizados. Así, el objetivo de este artículo fue incorporar una nueva perspectiva cuantitativa de medición del desempeño económico y analizar cuáles son los factores asociados a este. El universo de estudio fueron organizaciones de productores de giro agropecuario ubicadas en el estado de Guanajuato participantes en el programa «Comercialización innovadora»; la metodología consistió en calcular el valor agregado por la organización (VAO) como medida de desempeño, para lo cual se realizaron un análisis descriptivo, análisis de correlaciones (Pearson y Tau-b de Kendall), regresión lineal y ANOVA de un factor. Los resultados arrojaron que el VAO refleja el beneficio económico que reciben los socios por estar organizados, y que, de los factores asociados, el número de servicios ofrecidos por la organización es importante en la generación de VAO, así como la profesionalización de la estructura técnica.
El espíritu empresarial de los migrantes: una explicación de los antecedentes de la dinámica europea y española
Authors: Fashola Samson , Böcker Rafael , Brunet Icart Ignasi
Published: December 2022

La migración es, sin lugar a dudas, un fenómeno global, y cualquier país que pretenda prosperar económicamente en la coyuntura actual debe conceder una gran importancia a sus políticas migratorias. Se están explorando numerosas áreas en el campo de la migración, pero este artículo se centra en la esfera empresarial. Se trata de una revisión bibliográfica que engloba los trabajos realizados por académicos sobre el espíritu empresarial de los migrantes, centrada especialmente en Europa. En este sentido, se ha adoptado la teoría de la inserción mixta de Kloosterman como el enfoque científico principal para este artículo. De este modo, se han diseccionado diversas perspectivas académicas sobre el conjunto del espíritu empresarial de los migrantes en Europa. Este estudio también trata la perspectiva histórica y las oportunidades económicas de la migración en Europa. Además, se analizan en profundidad las publicaciones académicas sobre los determinantes del autoempleo de los migrantes.
Herbarium: The Quest to Preserve and Classify the World’s Plants
Authors: Bordelon Ashley
Published: December 2022

There may be no better way to learn about the history of botany and herbaria than through the lens of the former director of the second-largest herbarium in the world, Dr. Barbara M. Thiers. Thiers was no stranger to plant presses and herbarium cabinets when she became director, as she was the daughter of the herbariumcurator and founder of the Harry D. Thiers Herbarium at San Francisco State University. In Herbarium, Thiers expertly delivers centuries of botanical history from various geographies around the world.
The Linguistic Realisation of “Pandemic” Concept in Contemporary English
Authors: Shkvorchenko Nataliia , Pershyna Liubov , Sharapanovska Yuliia , Adamova Hanna , Leontiev Oleksandr
Published: December 2022

A concept can be treated in two different ways: as a linguistic-cognitive phenomenon and a cultural one. The components of the conceptual system are perceived as individual signals created while reflecting information about this world. The purpose of the paper is to compare, analyse and classify the linguistic structure of the concept of "pandemic" in the modern English language. The concept of “pandemic” is socially important as a key element included in the linguistic picture of the world of almost every language nowadays. The concept of pandemic comprises various nominative units: different grammatical forms of the word “pandemic”, phrases with the word “pandemic”, synonyms to the word “pandemic”, pandemic-related words. The research methodology consists of selection of cognitive classification features and further ranking their brightness by the frequency principle. The concept of pandemic was analysed according to the combination of the following linguistic methods: acquisition, computer analysis, quantitative method, induction and deduction. The first stage of the research included grammatical analysis of the empirical material. In the second stage of the research neologisms (new words), new meanings of the existing words and new collocations were found.  The research has proved the recent changes in the structure and perception of the concept of "pandemic" in the contemporary English language. The vocabulary of the English language has been, on the one hand, enriched while, on the other hand, has narrowed the meanings of some particular words. Further research is prospective as the concept of the pandemic still tends to be enriched.
The Dystopian Scourge of Women in Gilead Society as Portrayed in Margaret Atwood’s The Handmaid's Tale
Authors: V Victor Vinoth , M Vijayakumar
Published: December 2022

The Handmaid's Tale, Margaret Atwood's most renowned dystopian novel, is one of those works whose memorandum appears to transcend period. It has been analyzed to demonstrate the presence of various layers of feministic and dystopian cultural concepts in the novel. A qualitative investigation of secondary resources reveals that the situation of women in the novel is portrayed as a reproach to the patriarchal construction of the contemporary world. The women characters in the novel position as testimonies of the subjugation that unescapably concentrates them, helpless against a societal and political organisation that interprets the position of women as a reproductive machine. According to Atwood’s novel, by representing the repercussions of the revolution in the United States through the fake theocracy and totalitarian law insists, women must serve the commanders of Gilead society for sexual and biological reasons. Infertile women and working slaves should both serve as servants to the elite couple; the Handmaids addresses both historical and contemporary cultural issues, particularly those affecting women. This study further points out the oppressive, matriarchal position and sexual cruelty, diminishing the autonomy of women.
Visualising the Russia-Ukraine War: A Semiotic Analysis of Arab Social Media Cartoons
Authors: Al-Dala’ien Othman Aref , Al-Shboul Yasser , Aldowkat Issam M. , Al-Takhayinh Ayman
Published: December 2022

This study is a verbal-pictorial analysis of the Russia-Ukraine war in Jordanian cartoons. It examines socio-political contexts related to the Russia-Ukraine war through a semiotic analysis of selected political cartoons posted on the official Facebook accounts of two well-known Jordanian cartoonists, Emad Hajjaj and Osama Hajjaj, between January and September, 2022. These cartoons show the conflict through the eyes of Arabs, who may be considered neutral and distanced from the conflict. As such, the study provides novel insights for semiotics by analysing signs in verbo-pictorial entities and demonstrating how verbal and visual signs can work synergistically to connote powerful messages. Sixty-eight political cartoons were collected and classified into the themes of: negotiation, alliance, economic consequences (the food and energy crisis), the Russia-Ukraine war and COVID-19, the refugee crisis, Putin vs. peace, nuclear war, and the mocking of Putin’s policies. We selected a representative cartoon from each theme and analysed their messages via the Roland Barthes model (1967, 1977) according to three types of message: verbal (i.e., text), non-verbal (i.e., denoted visual signs), and symbolic. These verbal and visual signs were used to clarify and interpret the symbolic messages of the selected cartoons. The thematic findings reflect the views and attitudes of an Arab community (Jordanian, in this case) regarding the Russian-Ukraine war.
INCOME MODEL FOR ESTIMATING THE VALUE OF INTELLECTUAL CAPITAL OF THE ENTERPRISE
Authors:   Odessa National Economic University, Litvinov O.S.
Published: December 2022

The article is devoted to consideration of existing approaches to valuation of intellectual capital of enterprise (hereinafter - ICE). In particular, the emphasis is placed on the use of the income method of valuation. The purpose of the article is the theoretical and methodological substantiation of the author's model for assessing the value of ICP. To achieve the goal of the article the following tasks are set: to consider existing approaches to the valuation of IPE; to substantiate the special importance of the income method, to critically examine existing models and to propose the author's model; to test the model on the example of a group of enterprises. As a result of the analysis of existing scientific approaches to assessing the value of ICP, it was concluded that the authors distinguish market, cost and income methods. The priority of using the income method, which is based on the capitalization of surplus profits obtained through the use of ICP (as opposed to material and financial), is substantiated. The significant shortcomings of existing approaches are identified and the author's model based on the capitalization of the expected excess profit, which is the difference between the expected profit and the "normal" profit of the enterprise, is proposed. The model solves the following problems: taking into account the impact of IPC on profit, forecasting excess profitability, using statistical reporting data, taking into account changes in the value of money over time. The problem of choosing a capitalization method was solved by the author's proposed calculation of the indicator "capitalization multiplier of expected excess returns". The developed theoretical and methodological foundations for assessing the value and reproduction of ICP have been tested on the example of 14 largest machine-building enterprises of Ukraine for 2014-2017.
Monitoring of the safety of plant-based feed by the content of ecotoxicants
Authors: Kalyuzhnaya Tamara V. , Orlova Diana A.
Published: December 2022

Currently, the issues of the safety of plant-based feed in terms of the content of ecotoxicants remain relevant and are directly related to the intensification of the agro-industrial complex and ensuring the food security of the country. Thus, when assessing the possibility of using plant feeds, great importance is paid to monitoring the content of such ecotoxicants as toxic elements, pesticides, pyrene-free, radionuclides and others.

The accumulation of ecotoxicants on the territory of agricultural lands determines the need for regular monitoring of their content, and in polluted territories - the use of a system of agrotechnical and agrochemical measures for their detoxification. The main danger of ecotoxicants lies in their entry into the human body and animals through food, including plant origin, and accumulative capacity. In this regard, issues related to the study of the content of ecotoxicants in feed and plants of agricultural lands, assessment of the degree of pollution of agroecosystems have significance and relevance.
SOFT COMPETENCIES OF A WORKER: A MENTOR'S VIEW
Authors:   Precision Casting Center LLC, Shvetsov D.P.
Published: December 2022

The article reveals the need to define soft competencies of workers in modern production. The article presents a list of necessary soft-competencies and analyzes their key importance in the processes of modernization and introduction of innovations in the enterprise on the basis of mentor’s experience
THE SYSTEM OF TEACHER TRAINING FOR PARTICIPATION IN PROFESSIONAL SKILLS COMPETITIONS
Authors:   Ekaterinburg Economy and Technology College, Baydalo E.N.
Published: December 2022

The article analyzes the phenomenon of professional skills competitions for teachers. The article describes the practice of Ekaterinburg Economy and Technology College in developing a system that prepares college teachers to participate in professional skills competitions at various levels: the mechanisms of involving teachers in competitions are shown, the system of incentives and methodological support is described, the effectiveness of the developed system is presented.
The efficacy of neoadjuvant radiotherapy in patients with signet ring cell carcinoma of the rectum: a retrospective case control study
Authors: Gordeev S.  S. , Zagidullina A.  A. , Naguslaeva А.  А. , Mamedli Z.  Z. , Stilidi I.  S.
Published: December 2022

Introduction: Signet ring cell carcinoma of the rectum (SRCCR) is a rare rectal tumor, therefore, only limited information is available on the management of patients with this diagnosis. Since literature data on the susceptibility of signet ring cell carcinoma to radiation therapy (RT) are controversial, one of the questions that specialists may have is whether the RT is effective as the first stage of treatment.Materials and methods: We conducted a retrospective analysis of medical records of patients with SRCCR treated at Research Institute FSBI «N. N. Blokhin Oncology Center» of the Ministry of Health of Russia from 1998 to 2020. The inclusion criteria were as follows: histologically confirmed primary SRCCR, disease stage I–III, use of RT or chemoradiotherapy at the first stage. A case control study design was used to select a control group of patients with rectal adenocarcinoma, and each case of the control group was compared with the study group by the following criteria: the year of treatment, the cT and cN clinical stage, the use of RT or CRT. The main endpoint was the rate of Dworak tumor regression grade 3–4; secondary endpoints included 5-year overall survival (OS) and progression-free survival (PFS) rates.Results: The study and control groups included 16 patients each. In each group, 14 (87,5 %) patients received CRT and 2 (12,5 %) received RT; cT3, cT4 stages were diagnosed in 7 (43,8 %) and 9 (56,3 %) patients, respectively; cN0 and cN1–2 stages were diagnosed in 3 (18,8 %) and 13 (81,2 %) patients, respectively. Eight (50 %) patients in the SRCCR group and 4 (25,0 %) patients in the control group had Dworak tumor regression grade 3–4 (p = 0.273), and one (6,3 %) patient in each group showed pathological complete response (p > 0.99). The 5-year OS in the SRCCR group and the control group was 34,9 % and 51,4 %, respectively (p = 0.833); the 5-year PFS was 30,8 % and 35,6 %, respectively (p = 0.094).Conclusions: SRCCR is at least as susceptible to RT / CRT as rectal adenocarcinoma, for which neoadjuvant RT / CRT is the standard of care; the use of combination therapy produces comparable long-term results.
Secuencia rápida de intubación, una actualización para su abordaje práctico
Authors: Beltrán Castro Marvin , Muñoz Pedraza Diana
Published: December 2022

La presente revisión integra aportes recientes en el abordaje, detección de complicaciones y cambios en la medicación de la secuencia rápida de intubación, con un esquema MUR de manejo usual recomendado que podría ser beneficioso en la clínica.
Proximal Femur Replacement: Complexities and Learning Points
Authors: Lekhi Akshay , Patel Kuntal , Herlekar Deepak
Published: December 2022

Proximal femur replacement (PFR) or Proximal femur reconstruction is a way of salvaging excess bone loss in proximal femur and yet providing a total hip replacement The article aims to highlight the technical difficulties and comorbidities associated with this complex procedure of proximal femur replacement. We retrospectively evaluated eight complex typical PFR cases performed under the care of same team of two surgeons, from 2013 to 2021, to highlight the various technical difficulties and complications that may be incurred during such a major salvage surgery. This was intended to help prepare the fellows, colleagues and future surgeons to have a plan of action and holistic approach towards the process. Average age of 87.4 years makes it a challenge both pre-operatively and post operatively in view of comorbidities existing in this age, apart from the technical difficulties of PFR. Complications observed were difficult rehabilitation, infection, pulmonary embolism deep vein thrombosis, dislocation, limb-length discrepancies and death. This is a level IV evidence case series with individual case description along with respective radiographs.
Bridging Health Care and the Workplace: Formulation of a Return-to-Work Intervention for Breast Cancer Patients Using an Intervention Mapping Approach
Authors: Smeers Elke
Published: December 2022

Background: Women of working age who are diagnosed with breast cancer often experience a decline in their ability to work during and after treatment. A hospital-based tailored intervention is needed to restore their labour participation by bridging the gap between the healthcare setting and the workplace. The aim of this intervention is to restore the labour participation and, guided by an occupational therapist, to enhance the quality of life of BC patients during their return-to-work process. This paper mainly focusses on describing that intervention, including the research protocol to evaluate its feasibility and participant’s perceptions. Materials and Methods: The development of the BRIDGE intervention has yielded a roadmap that describes the individual patient’s path to return to work and includes tools for professionals. The Template for Intervention Description and Replication (TIDieR) guidelines were used to systematically describe the intervention. A feasibility study – designed as mimic RCT - was used as protocol for this study. Results: prepared by a phase 0 (indication phase), the five phases of the intervention are as follows: exploration; comparison; preparation; goal-setting and action planning; realisation and evaluation. An overview of the procedures involved, including the stakeholders in each phase and the materials to be used, is also presented. Results of the mimic RCT are currently analysed and prepared for publication. Conclusions: This five-phase BRIDGE intervention is performed by an OT and targets patients in paid work who have been diagnosed with BC. It aims to bridge the gap between the healthcare setting and the workplace.
Cardiovascular Sequelae of Covid-19 Infection in Post-Acute Phase
Authors: Patnaik Soumya , Patnaik Amar
Published: December 2022

The wide array of clinical manifestations of the ongoing COVID-19 pandemic due to the SARS-CoV-2 infection continues to be a big puzzle to the healthcare professionals. The picture is becoming complex with appearance of new strains and widespread vaccination against the viral infection. The acute cardiovascular manifestations are diverse; but have been fairly well-documented. But the mechanism behind the persistent symptoms like dyspnea, fatigue, chest pain and other symptoms in some of the survivors, weeks and months after the onset of initial infection are poorly understood. The post-acute and long-term cardiovascular impact of COVID-19 affection on heart and other systems is not fully clear. As the survivors after an acute episode are fast growing in number, managing them is emerging as a new public health concern. A recent study on cardiovascular outcomes of COVID-19 in post-acute phase by Xie et al in a cohort of 153,760 survivors of COVID showed that these individuals are at substantial risk of CV disorders like thromboembolic problems, arrhythmias, ischemic and non-ischemic myocardial injury, pericarditis, myocarditis and heart failure irrespective of the intensity of the initial infection. Currently, defining cardiovascular risk and predicting the long-term consequences in COVID survivors are issues of priority for the researchers and clinicians alike. The cardiac MRI is emerging as a useful tool to evaluate the myocardial damage in post-acute phase of COVID infection. This review is an attempt to analyze the existing knowledge and bring out the potential gaps in the understanding of these challenging issues after acute phase of COVID is over.
Mouse Norovirus Uses Host Metabolites to Enhance Receptor Binding and Evade Immune Recognition
Authors: Sherman Michael , Williams Alexis , Smith Hong , Wobus Christiane , Smith Thomas
Published: December 2022

Noroviruses are the major cause of epidemic gastroenteritis in humans, causing ~20 million cases annually, resulting in more than 70,000 hospitalizations and 570-800 deaths in the United States alone. The T=3 icosahedral calicivirus capsid is composed of viral protein 1 (VP1) with three major domains: the N-terminus (N), shell (S), and C-terminal protruding (P) domains. The S domain forms a shell around the viral RNA genome, while the P domains dimerize to form protrusions on the capsid surface. The P domain is subdivided into P1 and P2 subdomains, with the latter containing the binding sites for cellular receptors and neutralizing antibodies. Mouse norovirus (MNV) is a widely used system for study of norovirus biology since we have a cell culture system, reverse genetic tools, and small animal model to eventually correlate structural information to whole animal pathology Mouse norovirus is a surprisingly dynamic virus that switches between receptor and antibody binding structures depending upon the in-vivo environment. In the circulation, the P domain floats above the shell by more than 15Å and the P domain loops (A’B’/E’F’) at the very tip are splayed apart in an ‘open’ conformation that antibodies learn to recognize. Upon ingestion, the low pH environment with high metal and bile salt concentrations in the alimentary canal each independently trigger the P domains to rotate 90° and contract by 15 Å onto the capsid surface. This hides any epitopes at base of the P domain. During this reversible collapse, the two P domains within the dimer rotate about each other and the A’B’/E’F’ loops adopt the ‘closed’ conformation. This opens the receptor binding site while burying the epitopes at the tip of the P domain. Therefore, rather than only depending on escape mutations to block antibody binding, MNV aggressively uses host conditions to remodel itself to enhance receptor binding while blocking antibody recognition. This review will describe the structural processes and biological consequences of the virus responding to activating host cues in the gut while these same triggers bury the epitopes presented in the circulation. This is an aggressive and unique mode of immune escape that has been subsequently shown in other viruses such as COVID-19. Therefore, a deeper understanding of the dynamic processes of virus capsids will improve vaccine design by understanding how to present the epitope conformations at the site of infection rather than what is presented to the immune system.
Eradication of Borrelia Burgdoferi in vitro using Chlorine Dioxide: A Novel Approach
Authors: Georgiou George
Published: December 2022

Lyme disease, which is caused by the spirochete Borrelia burgdorferi is the most prevalent tick-borne illness in the world today and has grown into a major public health problem during the last decade, irrelevant to decades of efforts from various health professionals. The conventional treatment for Lyme disease is the use of a variety of antibiotics, but relapse often occurs when antibiotics are discontinued. There are several reasons why this relapse may occur, given that B. burgdorferi is a pleomorphic microorganism that can convert from vegetative spirochetes to a variety of different round bodies and biofilm colonies. Therefore, there is an urgent need for novel approaches that can eliminate all these different morphologies. This has challenged many health practitioners around the world, not to mention the suffering of many afflicted people. In this study, Chlorine dioxide (CD) at different concentrations was tested for its effectiveness in vitro against B. burgdorferi using combined fluorescent and darkfield microscopy with Live-or-Dye staining methods. Our experiments demonstrated that it is possible to completely eradicate all forms of B. burgdorferi at specific concentrations of Chlorine dioxide. Our extensive research has shown that Chlorine dioxide can be used for the eradication of B. burgdorferi morphologies. At certain concentrations of chlorine dioxide above 2 ppm the Borrelia morphologies appear to be eradicated as there is no motility of either spirochetes or round bodies, only biofilms visible. However, incubating again for another 7 days resulted in the Borrelia being motile again as they come out of the biofilms. We, therefore, decided to conduct each experiment with what we termed the Regrowth Kill Test (RKT) by incubating the initial sample with the CD in an incubator at 37 degrees centigrade in the Campypack for 7-days. It appeared that the biofilms that are quickly formed as soon as the CD is added in the initial experiment, broke up and released small spirochetes and round bodies of different morphologies. After numerous RKT experiments, it was determined that the concentration that resulted in a near complete disinfection of the spirochetes as well as round bodies was 30 ppm CD.
Precision Medicine Shows Promise to Advance the Care of Individuals with Hearing Loss
Authors: Pei Michelle , Colbert Brett , Smea Molly , Blanton Susan , Liu Xue
Published: December 2022

Hearing loss (HL) is the most common sensory disorder worldwide and arises from a heterogeneous set of genetic and environmental etiologies. Currently, therapy for sensorineural HL is non-specific and limited to amplification devices and implanted neuroprosthetics. Recent advances in the burgeoning field of precision medicine focused on individualizing disease diagnosis and tailoring treatment to each patient’s own biology hold great promise to provide tailored care for hearing loss patients. In this review, we discuss the current diagnostic algorithm and treatment options for hearing loss, the advances in using precision medicine tools to identify specific genetic variants that predispose to or result in hearing loss, the role of genetics in determining surgical outcomes following cochlear implantation, recent advances in gene and stem cell therapies for treating hearing loss, and patient-specific disease modeling using induced pluripotent stem cells. All of these precision medicine techniques will result in improved care for patients based on the precise etiology of their hearing loss.
A Review Assessing Participants’ Understanding of Informed Consent for Clinical Trials in Africa
Authors: Kazembe Dorothy , Mesfin Tigist , Abebe Abigiya , Embaye Saba , Muthoka Esther , Usmael Kedir , Ahmedin Mediha , Manyazewal Tsegahun
Published: December 2022

Background: Informed consent provides detailed information to the participants to make informed voluntary and rational decision to participate in a study. It is a communication tool between investigator and the subject to ensure that high research ethical standards are followed. This review paper assessed the level of participants’ understanding of the information given to them by researchers during the clinical research. Methods: A review approach was used to achieve the study objective. Results: The findings showed that the level of comprehension varied from study to study. There was a good comprehension in four domains; purpose, voluntariness, benefits and right to withdraw. Poor comprehensions were mostly in risks, side effects, and blinding. Higher level of education, repeated assessments of comprehension, time spent by the researcher explaining and clarifying the information influenced the comprehension. Conclusion: The study findings point out that comprehension to informed consent is still a challenge that needs to be addressed during the field study. Once the consent is given it becomes a distant memory for most of the participants. This implies that proper tools and cut off points to determine participants’ comprehension need to be developed for standard assessment of such.
Inhibition and eradication of Streptococcus pyogenes biofilm by phytochemical extracts of cranberry and sumac berry
Authors: Abachi Soheila , Rathgeber Bruce , Lee Song , Rupasinghe H.P.
Published: December 2022

Background: Diverse infections occur due to specific virulence factors of Streptococcus pyogenes, such as surface proteins and their biofilm formation capacity. This study aimed to assess the anti-biofilm effects of phytochemical-rich fruit extracts of cranberry (Vaccinium macrocarpon) and sumac berry (Rhus typhina). Methods: Biofilm inhibition and eradication potential of the berries were tested by metabolic activity measurement and viable cell count technique as well as visualization using scanning electron microscopy (SEM). Results: Minimum biofilm inhibitory concentration and minimum biofilm eradicating concentration of cranberry and sumac berry extracts ranged from 1 to >4 mg mL-1 and 2 to >16 mg mL-1, respectively. The effects of these extracts on the pre-formed biofilms and biofilm formation were imaged. The scanning electron microscopy images were indicative that the extracts could affect the integrity of bacteria hence quenching the biofilm formation capacity of S. pyogenes Conclusion: Further investigations on quorum sensing and exopolysaccharide formation can confirm the anti-biofilm potency of extracts.
Firefighters and Cancer: A Review of the Current State of Cancer Incidences and Recent Trends in Risk Perception and Risk Reduction Efforts
Authors: Harrison Tyler , Muhamad Jessica , Malova Ekaterina
Published: December 2022

Objective: This paper provides a review of current knowledge and trends in research on firefighters cancer risks and risk reduction efforts and calls for future research focused on European and international firefighters to understand and reduce occupational cancer risk. Cancer incidence: Firefighters face increased occupational cancer risk. Firefighting has been linked with multiple types of cancer, including bladder, colorectal, brain and central nervous system, non-Hodgkin’s lymphoma, skin melanoma, and prostate and testicular cancer, with several others types of cancer being found at increased rates. Cancer risks: Increased occupational cancer risk is, in part, related to carcinogenic exposures at fire events and improper use and cleaning of personal protective equipment (PPE), with role and years in service increasing risk. Risk Perception: Research on efforts to reduce cancer risk are growing, and include examination of firefighter knowledge, attitudes, norms, and behaviors toward decontamination, screening, and healthy eating. Many firefighters report high perceived susceptibility and severity of cancer risk, and identify fire scene exposures, contaminated gear, diet, sleep disruption, chemical exposure from cleaning products, and barriers to medical care as contributing to increased risk. Risk Reduction: Firefighters have strong desire to reduce cancer risk and report generally favorable attitudes toward decontamination practices and proper gear use, but face barriers to reducing those risks, including lack of knowledge, occupational needs, organizational culture, policy, and lack of resources. Behavioral interventions to reduce cancer risk through decontamination efforts and dietary change have demonstrated positive results, however there is a dearth of research on these efforts, especially with European and international firefighters. Future Directions: Future research should focus on understanding European and international firefighters’ knowledge, attitudes, and behaviors toward cancer risk reduction, the impact of the built environment on cancer risk (station layout, clean cabs), improved efforts at tracking exposures, use of new technology and virtual reality in training to reduce cancer risk, and improved understanding of firefighter cancer risk by medical professionals.
Pathogenesis of Crohn’s Disease
Authors: Kruiningen Herbert
Published: December 2022

There was a time when “pathogenesis” meant the genesis of the pathology, patho plus genesis. Today, however, the word is used to introduce topics such as immunodysregulation, alterations in the microbiome, or an imbalance of the two, some sort of disconnect between the patient’s flora and the immune system of the gastrointestinal tract. Pathogenesis, pathophysiology, and etiopathogenesis seem to be buzzwords, introduced to catch the eye of the reader or the editor. Few who use those words have seen any “pathology” since second year medical school, or perhaps they have viewed biopsies of the surface but not cut sections of resection specimens. Dalziel was the first to describe Crohn’s disease. Pathologists, or groups of pathologists, elucidated the pathogenesis, often referring to the granulomas, the obstructed lymphatics of the wall and the edema. Dalziel called this disease “chronic interstitial enteritis”. Those writing about microflora, immune dysregulation, cytokine cascades, fibrosis, and mouse models would do well to study the early pathology that is the essence of Crohn’s disease.
Indonesia’s Natural Rubber Productivity and Technically Specified Natural Rubber 20 Export: The Effect of El Nino Southern Oscillation
Authors: Cahyaningtyas Inaya , Utami Arini Wahyu , Waluyuti Lestari Rahayu
Published: December 2022

El Nino Southern Oscillation (ENSO) causes rainfall anomalies, which may disrupt Indonesia’s natural rubber production by interfering with the trees’ growth and affecting the export volume. This study analyzed the effect of ENSO dynamics on the monthly productivity of natural rubber and Technically Specified Natural Rubber (TSNR) 20 export. Monthly data from January 2006 to December 2019 were collected from the Statistics Indonesia, International Trade Centre (ITC), World Bank, Bank Indonesia, and National Ocean and Atmospheric Administration (NOAA). Descriptive statistics unveiled that strong La Nina increased the average of monthly productivity by 3.37% to 9.68%, while strong El Nino tended to decrease productivity by 1.30% to 9.27%. Moreover, the Vector Error Correction Model (VECM) demonstrated the negative effect of ENSO on Indonesia’s natural rubber export, both in the short and long term.
Pengembangan Lemari Asam dengan Variasi Kecepatan Putaran Exhaust Fan Menggunakan Sistem Otomatis
Authors: Aldio Rieza Zulrian , Panuh Dedikarni , Zaki Abdul Khadir
Published: December 2022

Lemari asam memiliki peran yang kritikal dalam sebuah laboratorium dan wajib memberikan keamanan bagi penggguna dari bahan kimia yang berbahaya. Terdapat exhaust fan yang berfungsi untuk menghisap udara atau uap dari asam Penelitian ini bertujuan untuk mengembangkan lemari asam dengan 3 kecepatan putaran exhaust fan pada 1513, 1770 dan 2125 rpm yang menggunakan sistem kendali otomatis. Dimensi lemari asam adalah 80 x 60 x 200 cm, terdiri dari 3 bagian utama yaitu exhaust fan, ruang kerja lemari asam dan bagian penyimpanan. Nilai efisiensi yang didapat dari perancangan adalah 1.05, 2.69 dan 4.05 % yang menunjukkan terjadinya peningkatan nilai efisiensi apabila kecepatan putaran meningkat. Maka peningkatan kecepatan akan meningkatkan efisiensi exhaust fan.
Migración y prensa ecuatoriana: Análisis de representaciones del inmigrante en pódcast entre 2020-2021
Authors: Garcia Torres Joaquin Antonio
Published: December 2022

El pódcast es un formato que ha ganado relevancia a escala mundial en los últimos años. Esta publicación registra los resultados de una investigación que analizó las narrativas de inmigración en 18 pódcast de tres medios de comunicación ecuatorianos, publicados entre 2020 y 2021. Por medio de un estudio cualitativo se observó que la construcción de representaciones migratorias aún es incompleta, presenta elementos estigmatizantes, y que en su mayoría los pódcast en el país no se utilizan como un formato innovador en el periodismo. No hay ángulos más inclusivos o con un enfoque de derechos. Las voces más comunes en la cobertura inmigratoria analizada fueron las de presentadores, políticos y expertos (políticos y expertos que son invitados a entrevistas, conducidas por presentadores). Las voces de los inmigrantes suenan en 11 % de los pódcast, y los analistas y reporteros están presentes en alrededor del 5 %.
Curaduría en contenidos periodísticos
Authors: Pino Coviello Álvaro Maximiliano
Published: December 2022

Las transformaciones en el periodismo se han acelerado en las últimas décadas. Ha cambiado la forma de financiar la actividad, las formas de consumir información y las prácticas profesionales. Es en este contexto de hiperinformación y fake news donde surge la curación de contenidos periodísticos. El trabajo da inicio a la discusión de su inserción como contenido curricular. Por medio del paradigma hermenéutico, también llamado constructivista, se busca conceptualizar la curaduría de contenidos periodísticos con fines de su incorporación como contenido pedagógico en los planes de estudio de las carreras de periodismo. Se describe el origen de la curaduría hasta su llegada al oficio periodístico, se caracteriza la curación de contenidos periodísticos y se fundamenta la necesidad del estatus académico para proporcionar a los estudiantes competencias para la práctica profesional debido al contexto de infoxicación y desinformación vigente.