bluuebunny/crossref_metadata_2025 huggingface dataset:
IDEOLOGICALLY-EDUCATIONAL AND CULTURAL ASPECTS OF TOURISM SPECIALISTS’ TRAINING IN THE PROCESS OF TEACHING THE COURSE OF «PHILOSOPHY»
Authors: YAROVYI Anatolii
Published: February 2020

The article deals with the social functions of philosophical factors in the formation of a modern model of tourism specialist. This model is formed and considered in accordance with the basic normative educational document - the Standard of higher education in the specialty 242 "Tourism" of the field of knowledge 24 "Sphere of service" by educational and professional program (OPP). The author makes a sample of some of the general competences provided by the educational-professional program of preparation of bachelors in the specialty "Tourism" and monitors the provision of appropriate substantiation of the nature of their provision in teaching the course "Philosophy". It is also substantiated that the philosophical and cultural approach in the system of tourism education allows the whole tourism industry to reach a higher level of self-awareness and adequately reflect a deeper understanding of tourism not just as a combination of travel and entertainment, but as a powerful factor in integrating and generating human spirituality. The author monitors these positions on the example of philosophical and cultural provision of relevant competencies of tourism specialists.
FINANCIAL AND ECONOMIC STATE OF ENTERPRISES OF THE AGRICULTURAL SECTOR OF ECONOMY IN CHERKASY REGION
Authors: SOKOLYUK Sergyi , FISCHUK Natalia
Published: February 2020

The article analyzes the average annual cost and dynamics of the introduction of new fixed assets of enterprises of the agricultural sector of economy. It is established that starting from 2016 there is a tendency to increase the value of fixed assets of enterprises of agricultural sector, which led to an increase in the growth rate of production of agrarian products and profitability. It is emphasized that in spite of positive changes in the dynamics of the new fixed assets introduction, the problem of fixed assets updating at the agricultural enterprises in the region remains unresolved. The tendency of operating assets value increase at the enterprises of the agricultural sector in the region is established. The significance of the analysis of the financial and economic state of agricultural enterprises according to the criteria of stability, solvency and business activity are considered through the prism of indices of capital structure, liquidity and turnover, which makes it possible to quantify the impact of quality management of financial resources on the level of profitability and dynamics of enterprise development. According to the results of the analysis of the enterprises of the agricultural sector of the region, their unsatisfactory financial and economic status

was established. In this regard, it is proposed to strengthen the material and technical base of enterprises, to introduce material, energy and labor-saving technologies; develop and implement in agrarian production progressive methods of economy.
ORDER OF FORMATION AND USE OF LOCAL BUDGETS OF UTC IN VINNYTSIA REGION
Authors: PRONKO Lyudmila , SEMENENKO Viktor
Published: February 2020

The article analyzes the implementation of the local budgets of the UTC of the Vinnytsia region. The achievements of the local self-government reform in terms of the effectiveness of management of the budget resources of the united territorial communities were determined. An analysis of the financial capacity of the budgets of the joint territorial communities of the region. The problematic aspects of the financial provision of the execution of functions by the local authorities are singled out. The ways of improving the territorial organization of power on the principles of decentralization and construction of financially self-sufficient territorial communities are proposed.

Currently, financial autonomy of local budgets of UTC is provided by the relevant legal norms of the Budget Code of Ukraine. The implementation of individual steps of fiscal decentralization also expanded the financial autonomy of local budgets through: the establishment of uniform norms of deductions from national taxes; the difference between the indicative planning system of the local budgets of the Ministry of Finance of Ukraine; formation of a single basket of general fund revenues and expansion of the source of its filling; formation and putting into operation of the system of equalization of the tax capacity of the territory, etc.
Index of Seaweed Algebras and Integer Partitions
Authors: Seo Seunghyun , Yee Ae Ja
Published: February 2020

The index of a Lie algebra is an important algebraic invariant.  In 2000, Vladimir Dergachev and Alexandre Kirillov  defined seaweed subalgebras of $\mathfrak{gl}_n$ (or $\mathfrak{sl}_n$) and provided a formula for the index of a seaweed algebra using a certain graph, a so called meander.

In a recent paper, Vincent Coll, Andrew Mayers, and Nick Mayers defined a new statistic for partitions, namely  the index of a partition, which arises from seaweed Lie algebras of type A. At the end of their paper, they presented an interesting conjecture, which involves integer partitions into odd parts. Motivated by their work, in this paper, we exploit various index statistics and the index weight generating functions for partitions.  In particular, we examine their conjecture by considering the generating function for partitions into odd parts.  We will also reprove another result  from their paper using generating functions.
The Use of Methylene Blue in Early Detection of the Vocal Fold Cancer
Authors: Hainarosie Razvan , Zainea Viorel , Ceachir Octavian , Hainarosie Mura , Pietrosanu Catalina , Stefanescu Cristian Dragos
Published: February 2020

Laryngeal cancer represents an important problem in the public health department, mainly due to the fact that the lack of early symptoms leads to most cases being diagnosed in advanced stages, when surgical procedures must be extensive and will affect the quality of life of the patient. Nowadays, the problem of early diagnosis of laryngeal cancer and procedures that may facilitate it is of great importance, with contact endoscopy following in vivo methilene blue coloration being one of the most promising options.
The Structure and Porosity of Fe62-xCo10WyMexY8B20-y Alloys in the Amorphous and Crystalline States (where: Me = Mo, Nb; x = 0, 1, 2; y = 0, 1, 2)
Authors: Nabialek Marcin , Pietrusiewicz Pawel , Szota Michal , Abdullah Mohd Mustafa Al Bakri , Sandu Andrei Victor
Published: February 2020

The investigated crystalline and amorphous samples were obtained by crystallization of the liquid alloy on a water-cooled copper plate and by an injection-casting method, respectively. In each case, the structure of the samples was determined by examination of the obtained X-ray diffraction patterns. The diffraction patterns of samples produced by the injection casting method were characterized by a single broad peak called the amorphous halo. The samples produced by the crystallization method were shown to feature within their structure the following phases:YB2, Fe2Y, �-Fe, Co5Y, and B6Co23. Further research, performed using computer tomography, revealed the existence of pores within the samples. The crystalline-structure samples were found to feature a lower average pore diameter.
Vitamin K Influence on Cardiovascular Mortality in Chronic Hemodialysed Patients
Authors: Radulescu Daniela , Balcangiu Stroescu Andra Elena , Pricop Catalin , Geavlete Bogdan , Negrei Carolina , Bratu Ovidiu , Ginghina Octav , Vacaroiu Ileana Adela
Published: February 2020

Cardiovascular disease causes increased mortality in chronic hemodialysed patients. The decrease of vascular calcification is one of the main targets in the management of these patients. According to several experimental and clinical trials, choosing the proper diet and prescribing vitamin K2 supplements help to improve prognosis and decrease mortality, but further larger researchers are required to advocate the importance of this dietary intervention in hemodialysed population.
New 4-(4-Hydroxyaryl)-5-Methyl-1,3-Dithiol-2-ylidene Derivatives
Authors: Matei Mihai , Sandu Ion , Birsa Mihail Lucian , Sarbu Laura Gabriela , Simion Laurentiu
Published: February 2020

New 4-(3,5-dibromo-4-hydroxyphenyl)-5-methyl-1,3-dithiol-2-ylidene derivatives have been synthesized from the reaction of the corresponding 4-(4-hydroxyaryl)-2-N,N-dimethylamino-1,3-dithiol-2-ylium perchlorate with various methylene active compounds under basic conditions. The 1,3-dithiol-2-ylium compounds have been obtained from the reaction of the substituted a-bromo-4-hydroxypropiophenone with sodium N,N-dimethyldithiocarbamate.
Preliminary Data Regarding Decreased Catalase Specific Activity in the Tears as a Result of Environmental Stress
Authors: Alexa Anisia Iuliana , Cantemir Alina , Ciobica Alin , Gardikiotis Ioannis , Antioch Iulia , Honceriu Cezar , Zamfir Carmen Lacramioara , Poroch Vladimir
Published: February 2020

Oxidative stress represents the imbalance between the production of reactive oxygen species and the organism�s capacity to produce antioxidants. This phenomenon has captured lately a lot of attention, with an additional increased interest being manifested towards the relationship between psychological stress and oxidative stress. In the present study we decided to observe the changes which occur in stress environmental conditions applied to rats subjected to swimming and treadmill exercises, by focusing on a preliminary determination of (CAT) specific activity, an enzyme known to catalyse the decomposition of hydrogen peroxide into water and oxygen, and a valuable antioxidant protector, with possible implications into the dry eye pathology. Our results could suggest a possible dry eye animal model induced through stress and a possible implication of the oxidative stress markers in the occurrence of this ocular pathology, as suggested by the significant decrease in the CAT activity registered in rat tears collected after the application of environmental stressors (e.g. swimming and running) versus the control group.
Study Regarding the Effect of Some Remineralizing Products Used in the Treatment of Erosion Induced by Sport Drinks
Authors: Andrian Sorin , Iovan Gianina , Ghiorghe Angela Cristina , Pancu Galina , Georgescu Andrei , Antonescu Dana Nicoleta , Stoleriu Simona
Published: February 2020

The aims of the study were to evaluate and to compare the effects of some commercial sport drinks on enamel and dentine when using remineralizing products before the use of these beverages. Enamel and dentine fragments were immersed five times, 3 min each during 2 h, fourteen days, in three sport drinks: Gatorade beverage (PepsiCo), Isostar (Isostar) and Cyto Max (CytoSport). On other tooth fragments three remineralizing products were applied before the immersion in sport drinks: Colgate Total� toothpaste (Colgate Company), a fluoride gel (Densell Company), and MI Paste Plus product (GC Company). In all the samples the enamel and dentine hardness were determined using a digital device CV 400 DAT (Namicon). Gatorade beverage leaded to the highest demineralization of the enamel and dentine, followed by Isostar and CytoMax. All three remineralizing products used before the acid attack determined increased values of enamel and dentine hardness when compare to the values obtained when only the acidic beverages were applied. The highest enamel and dentine protection were recorded when MI Paste Plus product was applied, followed by fluoride gel and toothpaste products.
The Use of Polymerase Chain Reaction (PCR) for Indentifying Periodontopathogenic Bacteria - therapeutic Implications in Periodontal Disease
Authors: Lazar Luminita , Bica Cristina Ioana , Martha Krisztina , Pacurar Mariana , Bud Eugen , Lazar Ana Petra , Lorinczi Lilla
Published: February 2020

Polymerase chain reaction (PCR) shows a high specificity and allows us to identify pathogenic periodontal bacteria. We chose 45 patients wich were divided into three groups with various types of treatment: (I) - SRP; (II) - SRP, followed by topical application of antiseptics (SRP + local); (III) - SRP followed by systemic administration of antimicrobial agents (SRP + systemic). We collected samples from the initial time (TO) and one month after the treatment (T1) for each patient. For the microbiological assessment of periodontal therapy, we analyzed 90 subgingival plaque samples using PCR technique which provides qualitative data on five periodontopathogenic bacteria species: A. actinomycetemcomitans, P.gingivalis, P.intermedia, T.forsythia, and T.denticola. The treatment was followed by a qualitative change of the bacteria detected previously in a different ratio depending on the treatment. We found the inefficiency of mechanical treatment regarding the reduction of periodontal bacteria in patients belonging to group I, an improvement in the results of group II, while the treatment in group III proved to be the most effective . In patients detected A.a+ and/ or P.g+ a systemic antibiotic treatment is required because these periodontal bacteria penetrate the tissue and mucosal surfaces of the oral cavity.
Diseases Prevention by Water Defluoridation Using Hydrotalcites as Decontaminant Materials
Authors: Duceac Letitia Doina , Dobre Cristina Elena , Pavaleanu Ioana , Calin Gabriela , Nichitus Simona , Damir Daniela
Published: February 2020

Preventing diseases is deemed to be the major goal of our century especially when an excessive fluoride in drinking water can cause dental fluorosis, bone stiffness, rheumatism and skeletal fluorosis. Fluoride uptake from groundwater implies a worldwide multidisciplinary effort in order to develop renewable, cheap, human friendly materials. Among other materials, hydrotalcites could be good candidates for an efficient fluoride removal from water due to their adsorption, anion exchange and reconstruction properties. These nanostructured materials were synthesized using co-precipitation method in controlled conditions. Presence of anions in the interlayer structure and morphological aspects were performed by FTIR and SEM techniques. Thermal treatment of hydrotalcites showed good adsorption capacities for water defluoridation mostly due to their tendency to restore the original structure.
The Impact of the Industrial Processing of Oil on the Rainfall Water Quality
Authors: Chivu Oana Roxana , Semenescu Augustin , Babis Claudiu , Amza Catalin , Iacobescu Gabriel , Apostolescu Zoia , Petrescu Valentin , Adir George Mihail
Published: February 2020

Rainfall is a major component of the environment and the main source of the air purification becouse of many pollutants increases who have the most varied sources: various human activities including industry and agriculture, and some household duties. Air purification by means of precipitation is achieved by numerous highly complex mechanisms. The final products of degradation of the pollutant in the air, which are generally harmless, can be reacted with each other in the presence of water, giving rise to the final compounds with a high toxicity. Thus, exhaust, mobile sources of noxious almost identical to those specific activities in the industrial processing of oil, contain lead which is the ideal catalyst for converting SO2 to sulfuric acid in the presence of rainwater, with all the disadvantages that they create. This paper will present an experimental research oabout how rainfall water quality is influenced by the activity of the industrial processing of oil, in a chemical plant in Constanta County.
Thermal Behavoiur of Valsartan Active Substance and in Pharmaceutical Products
Authors: Tita Ioana Cristina , Tita Bogdan , Toma Claudia Crina , Marian Eleonora , Vicas Laura
Published: February 2020

G/DTG and DSC curves provide important information regarding the physical properties of the pharmaceutical compounds (stability, compatibility, polymorphism, kinetic analysis, phase transitions etc). The thermal behaviour of valsartan was studied under dynamic nitrogen atmosphere, in comparison with pharmaceutical products containing the corresponding active substances. Also, the FT�IR spectra and X-ray diffactogram of the same samples were recorded. The main conclusion of this comparative study was that TG / DTG and DSC assays along with FT-IR spectra and X-ray diffractograms provide credible data for differences between active substance and pharmaceutical forms.
Synthesis of Calcium Carbonate Micro Particles using Emulsion Membrane Process Applied for Drug Release Studies
Authors: Mateescu Mariana , Doncea Sanda Maria , Chican Irina , Nistor Cristina Lavinia , Bujanca Ioneta Codrina
Published: February 2020

The aim of this work is the synthesis of calcium carbonate (CaCO3) nano and microparticles and their application as biomaterials (vehicles) for the sustained release of doxycycline. CaCO3 micro particles were synthesized by water-in oil (W/O) emulsion method using emulsion liquid membranes with bis (2-ethylhexyl) phosphate (D2EHPA) as carrier, Span 80 as surfactant, and toluene and kerosene as organic solvents. The aqueous phases contained 1 M CaCl2, and 1 M Na2CO3, respectively. The Dynamic Light Scattering (DLS) data showed CaCO3 particles with sizes ranging from around 100 nm to 3500 nm. The CaCO3 particles with the average diameters around 600 nm attained an adsorbtion of doxycycline of maximum 97.9%, and a slow and steady release with a cumulative value of approximative 50% after ten days.
Biochemical Modifications Related to Calcium Deficiencies in Obesity and After Laparoscopic Sleeve Gastrectomy
Authors: Timofte Daniel , Ochiuz Lacramioara , Ursaru Manuela , Ciuntu Bogdan , Ionescu Lidia , Calu Valentin , Mocanu Veronica , Puia Ion Cosmin
Published: February 2020

Lately there is some discussion about an inverse relationship exists between calcium intake and obesity markers such as body weight, weight gain or body fat percentage. However, numerous studies question the idea whether adequate calcium nutrition can prevent or even reduce obesity. However, the disagreement from many studies seems to have more to do with the interpretation of the data than the data itself, with different hypothesis which could be valid in different specific populations. Still, the major finding we present here are in line with previous research demonstrating that lower levels of serum calcium are common after bariatric surgeries.
Aging Study of Gold Nanoparticles Functionalized with Chitosan in Aqueous Solutions
Authors: Lupusoru Raoul Vasile , Simion Laurentiu , Sandu Ion , Pricop Daniela Angelica , Chiriac Aurica , Poroch Vladimir
Published: February 2020

We studied the way in which stability and physicochemical properties of gold (Au) nanoparticles (NP) coated with chitosan are influenced by the molecular weight of chitosan and Au precursor concentration when samples are subjected to aging. Pharmaceutical use of AuNPs coated with chitosan is closely related to stability and physicochemical properties in relation to storage conditions and processing. For this purpose, series of AuNPs of different sizes were prepared by aqueous chemical reduction method using chitosan with various molecular weights as template. The physicochemical properties and stability at room temperature of AuNPs in aqueous solutions of chitosan have been investigated by following the temporal evolution of surface plasmon absorbance, Zeta potential, average dimension, and Au-chitosan interaction, after synthesis and through a period of 24 months. In our experiment, during the observed aging period, the AuNPs coated with chitosan presented a better colloidal stability, while using chitosan with medium molecular weight and medium concentration of Au precursor.
Nutritional and Food Safety Aspects Related to the Consumption of Edible Mushrooms from Dambovita County in Correlation with their Levels of Some Essential and Non-essential Metals
Authors: Georgescu Andreea Antonia , Danet Andrei Florin , Radulescu Cristiana , Stihi Claudia , Dulama Ioana Daniela , Buruleanu Claudia Lavinia
Published: February 2020

Ten edible mushroom species collected from four sites of Dambovita County, Romania, were analyzed through ICP-MS technique in order to evaluate their content in Fe, Cu, Zn, Pb and Cd, both in cap and stipe. Wild growing species (Russula vesca, Russula alutacea, Macrolepiota procera, Cantharellus cibarius, Boletus edulis, Agaricus campestris and Pleurotus ostreatus) and cultivated species (Pleurotus ostreatus, Agaricus bisporus white and Agaricus bisporus brown) were taken into account. The data related to the elemental composition of the fruiting bodies of mushrooms are important to be known having in view the nutritional and food safety related aspects. Higher concentrations of copper, iron and zinc have been found in Pleurotus ostreatus (cap), Macrolepiota procera (stipe) and Pleurotus ostreatus cultivated (cap) respectively, as follows: 43.90�0.96 mg/g d.w., 715.15�4.52 mg/g d.w. and 379.33�2.05 mg/g d.w. Although significant Health Risk Index were determined for lead in Agaricus campestris (about 0.1 both in cap and stipe) and for cadmium in Pleurotus ostreatus (0.58 in cap), these values are under the regulated PTWI limits for adult person.
Statistical Hierarchy of Diagnostic Criteria for Chronic Myeloid Leukemia
Authors: Calamar Popovici Despina , Ionita Ioana , Ionita Claudiu , Marinita Andrada , Moleriu Radu Dumitru , Ionita Hortensia , Iacob Daniela , Chiriac Veronica Daniela , Petre Izabella
Published: February 2020

The rational design of treatment is affected by two contradictory requirements: for diagnosis it is necessary to take into account all the factors of influence in the disease system, which requires long time and additional costs and also It is necessary to minimize the number of clinical determinations or the optimization of the medical act. A solution for eliminating this contradiction would be to reduce the number of parameters.
The purpose of this study is to reduce the number of parameters by selecting factors with major influence in the course of the disease .This study began with the inventory of the diagnostic factors registered in the clinical observation sheet of 140 patients diagnosed with chronic myelogenous leukemia at the Hematology Department of Timisoara during January 2006 - January 2016. The statistical method of rank correlation used is a very effective solution of the problem, applicable in the medical field. The statistical hierarchy of the diagnostic criteria determines their ranks and allows focusing attention on the most important ones. The presented statistical study creates the theoretical and practical premises for the treatment to be differentiated, the disease to be recognized in a period as early as possible.
The Heavy Metals Sensing Based on 2,6-Bis(-2-(Thiophen-3-yl)Vinyl)-4-(4,6,8-Trimethylazulen-1-yl)Pyrylium Modified Electrodes
Authors: Lazar Ioana Georgiana , Diacu Elena , Buica George Octavian , Ungureanu Eleonora Mihaela , Arnold Georgiana Luiza , Birzan Liviu
Published: February 2020

This paper focuses on electrochemical characterization of new azulene compound 2,6-bis((E)-2-(thiophen-3-yl)vinyl)-4-(4,6,8-trimethylazulen-1-yl)pyrylium (L) by cyclic voltammetry (CV), differential pulse voltammetry (DPV), rotating disk electrode voltammetry (RDE) on glassy carbon disk working electrodes. The character of redox processes was established by CV and RDE using increasing scan rates at different scan domains. PolyL modified electrodes have been prepared by scanning or controlled potential electrolysis (CPE). The complexing properties of L and polyL have been investigated towards detection of heavy metal ions by anodic stripping technique. The voltammetric curves present well defined peaks for Pb2+, Cd2+, Cu2+ and Hg2+, which can be used as analytical signals for their determination. The performances of the modified electrodes obtained at different potentials and charges have been evaluated. The best results have been obtained for Pb2+ and Cd2+ with the achievement of detection limits of 10-7 M.
Microarray Technology for the Detection of Antimicrobial Resistance Genes Present in Hospital and Community Acquired Methicillin Resistant S.aureus Strains
Authors: Licker Monica , Anghel Andrei , Moldovan Roxana , Hogea Elena , Muntean Delia , Horhat Florin , Seclaman Edward , Tamas Liviu , Anghel Mariana , Baditoiu Luminita
Published: February 2020

Antimicrobial resistance (AMR) represents a real burden for the modern medicine. One of the most frecvently isolated hospital acquired (HA) pathogens wordlwide, is Methicillin resistant Staphylococcus aureus (MRSA). Recently not only HA, but also community-acquired MRSA (CA-MRSA) infections have been reported. A prospective study was performed between February 2009 and October 2010, with the aim to investigate bacterial resistance of CA-MRSA and HA-MRSA. DNA microarray technology has been used for the detection of 4 AMR genes for the studied MRSA strains. A number of 218 HA- S.aureus strains have been isolated, from which 89 (40. 82%) were MRSA. In the community, 1.553 S.aureus strains were isolated, out of which, 356 (22. 92%) were MRSA. From these, a number of 17 HA and 12 CA �MRSA strains have been analyzed by DNA microarray technology. From 100% phenotypically described HA- MRSA, we identified mecA gene in 10 strains (58. 83%). Other 6 strains (35. 29%) have been erm(A) positive and 4 (23. 53%) - tet(O) positive. 83. 33% (10 strains) from the CA strains had mecA gene, only one (8. 33%) was erm(A) positive and 4 (33. 33%) were erm(C) positive. DNA microarray is a method allowing the concomitant scan of multiple genes and can be done within a few hours. That type of rapid and reliable methods for antimicrobial sensitivity tests are important to start an appropriate therapy.
Impact of Intensive Dietary Counseling on Serum Albumin in Haemodialysis Patients with Chronic Liver Disease
Authors: Nitoi Luciana Carmen , Florea Laura , Stefan Alina Aspazia , Ionita Cristian , Andrei Carina , Dascalu Cristina , Vulpoi Carmen
Published: February 2020

People on maintenance haemodialysis (MHD) are at risk of developing malnutrition, which is defined as the consequence of insufficient food intake or a suboptimal quality diet. The kidney and the liver play a central role in protein metabolism. The major aim of the study was to evaluate, for the first time in Romania, the impact of intensive dietary counseling and personalised diets on serum albumin (SA) and others nutritional parameters, but also the relationship between albumin level, inflammation and nutritional status in a cohort of haemodialysis patients which associate or not chronic liver disease (CLD). We prospectively analysed the inflammatory status and malnutrition in 162 HD patients, mean age 56�13 years, from a single dialysis centre. At baseline we evaluated: a. calorie-protein intake using patient�s diet history with the help of 72 hrs recall method;b. nutritional status by anthropometric measures- post dialysis body weight (BW), body mass index (BMI), TSF (tricipital skinfold), MAC (mid-arm circumference), MAMC (mid-arm muscle circumference);c. modified subjective global assessment score (mSGA);d. biochemical tests: pre-dialysis serum albumin, serum creatinine, alkaline reserve, Kt/V and Protein C Reactive (CRP). The patients were followed-up for 6 months.
The Efficiency of Co/CeO2 Catalyst in Ethanol Steam Reforming Process
Authors: Matei Danuta , Ezeanu Dorin Stanica , Cursaru Diana
Published: February 2020

A Co/CeO2 catalyst for ethanol steam reforming process was prepared and characterized using different characterization techniques including X-ray diffraction, UV-Vis diffuse reflectance, FTIR spectroscopy, scanning electron microscopy (SEM), N2 adsorption/desorption isotherms (BET) and thermal analysis method (TGA). The catalytic test in ethanol steam reforming process showed a high H2 yield and almost complete ethanol conversion.
Comparative Evaluation of Hardness and Elasticity Modulusof Tooth-Colored Materials for Dental Restoration
Authors: Ghiorghe Cristina Angela , Iovan Gianina , Carlescu Vlad , Istrate Bogdan , Pancu Galina , Andrian Sorin
Published: February 2020

The aim of this study was to compare Rockwell hardness (HRC) and modulus of elasticity (Young modulus) to different restorative materials. Three commercial composite resins: Filtek Z250 (3M ESPE Co.), Zmack Comp (Zermack SpA, Italy), Kalore (GC Corporation, Japan) and one compomer: Dyract eXtra (Dentsply De Trey Gmbh, Germany) were used. Six samples of each material were obtained by placing them in plastic rings having 5 mm inner diameter and 6 mm high. All composite samples were cured for 40 s using a lamp LEDidition - Ivoclaire Vivadent clinical, Austria. The samples were finished and polished and then stored in distilled water, at room temperature for 48 hours. Rockwell Hardness (HRC) measurements were realized using the UMT-2 Tribometer (CETR). The hardness was automatically calculated from the slope of unloading curve and expressed in GPa and transformed in HRC values (kgf/mm2). Six indentations were performed on diametral direction and mean values were calculated for all tested samples. The device also measured the modulus of elasticity for each sample. Data were analyzed by ANOVA and Mann-Whitney test (significance level of p [ 0.05). The mean HRC values were the following: Filtek Z250 ] Zmack Comp ] Dyract eXtra ] Kalore (82.98 ] 70.10 ] 53.27 ] 37.72 kg/mm2). Regarding Young modulus, the rank from highest to lowest as follows: FiltekZ250 ] Zmack Comp ] Dyract eXtra ] Kalore (16.24 ] 14.05 ] 12.41 ] 7.86). The microhydrid composite resins have a significantly higher hardness than nano-hybrid composites or compomers.
Etching Treatment Effect on Surface Morphology of Dental Structures
Authors: Earar Kamel , Antoniac Vasile Iulian , Baciu Sorana , Bran Simion , Onisor Florin , Milea Claudia , Mohan Aurel , Grigoroiu Raluca , Saceleanu Adriana , Manole Marius
Published: February 2020

This study examined and compared surface of human dentine after acidic etching with hydrogen peroxide, phosphoric acid liquid and gel. Surface demineralization of dentin is necessary for a strong bond of adhesive at dental surface. Split human teeth were used. After application of mentioned substances at dentin level measures of the contact angle and surface morphology were employed. Surface morphology was analyzed with the help of scanning electron microscopy and atomic force microscopy. Liquid phosphoric acid yielded highest demineralization showing better hydrophobicity than the rest, thus having more contact surface. Surface roughness are less evident and formed surface micropores of 4 �m remained open after wash and air dry providing better adhesive canalicular penetration and subsequent bond.
Glucocorticoids and Postoperative Disease in Oral - Maxillofacial Surgery
Authors: Budacu Cristian Constantin , Ibric Cioranu Sorin V. , Chiscop Iulia , Mihai Constantin
Published: February 2020

Postoperative manifestations like pain, edema, affected oral functions provoke transitory morbidity in patients to a late recovery. Various classes of medicines are prescribed to prevent placing patients in such unpleasant situations. Both dexamethasone and methylprednisole can be used to reduce the manifestations of the postoperative disease. Although the state of local inflammation is precursory to healing, its exacerbation can lead to extremely painful severe local edema through tissue distention. In the initial phase of the inflammatory process, glucocorticoids act as producers of vein-active substances like prostaglandins and leukins, as dexamethasone has a recognised capacity of reducing COX-2, which is responsible for generating PGs which are produced within the inflammatory response. The efficiency of glucocorticoids is admitted in reducing the inflammatory state, lying at the top of oral maxillofacial surgeons�s choice in the therapy of postoperative manifestations. Our research was addressed to a lot of 68 patients to whom we performed interventions of oral and maxillofacial surgery at the Outpatient Clinic of Oral-Maxillofacial Surgery of Ia�i. Dexamethasone is a strong glucocorticoid with the following chemical formula: 90-fluoral-160 methylprednisole. The antiinflamatory effect of a 0.75 mg dosis of dexamethasone is equivalent to that produced by 5 mg of Prednison. Dexamethasone is more efficient than Medrol in the treatment of postoperative edema with complete remission of symptomatology.
The Composition of Essential Oils Obtained from Achillea millefolium and Matricaria chamomilla L., Originary from Romania
Authors: Berechet Mariana Daniela , Manaila Elena , Stelescu Maria Daniela , Craciun Gabriela
Published: February 2020

In the present study we have investigated the chemical composition of the essential oils extracted by the procedure of hydrodistillation, from fresh flowers of Matricaria Chamomilla L. and Achillea Millefolium from Romania, two genres belonging to the same family, Asteraceae. The obtained essential oils were analyzed using the techniques of Gas Chromatography coupled with Mass Spectrometer and Fourier Transform Infrared Spectroscopy. It was found that both essential oils were dominated by the presence of terpenes. Aliphatic components were modest represented in both essential oils. The results were compared with those reported by other authors. Similarities consist in the domination of the same class of compounds and in the same modest representation of others. One of differences consists in the presence of some compounds with significant medicinal role, which were not reported by other authors. Another difference consists in the presence of some compounds in higher concentrations than those reported by other authors.
AFM and SEM Characterization of Chemically Modified Electrodes Based on 5-[(azulen-1-yl) methylene]-2-thioxothiazolidin-4-one
Authors: Pop Maria Daniela , Brincoveanu Oana , Cristea Mihaela , Buica George Octavian , Enachescu Marius , Ungureanu Eleonora Mihaela
Published: February 2020

Preparation and microscopy characterization of polymer modified glassy carbon electrodes based on (5-[(azulen-1-yl) methylene]-2-thioxothiazolidin-4-one (L) were reported. Atomic Force Microscopy was used to investigate the morphological and mechanical properties of the deposited polyL films onto glassy carbon. The topography images of the analyzed samples exhibited the presence of some columnar shape features onto the layer surfaces. The surface roughness of the layers deposited at constant charge calculated from topography images, increased with the more positive applied potential for controlled potential electrolysis. At different charges, the roughness parameter showed the same behavior for the layers obtained applying a constant potential without having a noticeable influence on the adhesion properties on the substrate. Analysis using scanning electron microscopy shows a relatively uniform surface arrangement of the polymer and the presence of some clusters which are disturbing the planarity. PolyL chemically modified electrodes have been used for heavy metal ions detection with best results for lead.
The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure
Authors: Puiac Claudiu , Jung Ioan , Puscasiu Lucian , Szederjesi Janos
Published: February 2020

The aim of this study was to evaluate the correlation between serum and tissue level of the Neutrophil gelatinase-associated lipocalin (NGAL), a peptide that seems to be predict the postoperative evolution of patients with high abdominal pressure. From 30 consecutive patients hospitalized in the Intensive Care Unit, we have randomly selected five cases that undergo abdominal surgical interventions, received postoperative mechanical ventilation and abdominal pressure was monitorized for at least 48 hours. In all of these cases, the plasmatic level of NGAL was measured using the Elisa method and immunohistochemical (IHC) stains with the anti-NGAL biomarker were performed in the surgically removed tissues. All of the five patients were overweight, showed high serum level of NGAL (over 950 ng/ml) and died with postoperative or septic shock. The NGAL serum level was not correlated with the abdominal pressure. No IHC positivity was observed in the examined tissues, except NGAL positivity for intravascular neutrophils. In conclusion, the postoperative high serum NGAL level may indicate unfavorable evolution. NGAL seems to be syntesized by the circulating neutrophils and its preoperative tissue expression does not reflect the serum value.
Periodontitis and Cardiovascular Risk
Authors: Negru Robert D. , Georgescu Andrei , Ciuntu Bogdan Mihnea , Andrian Sorin , Stoleriu Simona , Badulescu Oana Viola , Ciuntu Roxana , Cojocaru Doina Clementina
Published: February 2020

Atherosclerosis is a major component of the cardiovascular diseases and is centered by inflammation but its well-known predictors do not explain some of the atherosclerotic vascular disease events, generating the need to look for independent additional risk factors. Periodontitis, a chronic infection produced by oral bacteria and affecting the supporting structures of the teeth, seems to be linked with atherosclerosis and cardiovascular disease through several mechanisms, like genetic susceptibility, systemic inflammation, infection, and the molecular mimicry, the association being worsened in the presence of diabetes. The epidemiological studies revealed a modest but significant association between periodontal infections and cardiovascular disease, independent of the effect of confounding factors, but the definite effect of periodontitis and its treatment on the incidence of cardiovascular events requires further clarifications.
The Study of Natural Saponification Processes in Preservation of Human Corpses
Authors: Hanganu Bianca , Velnic Andreea Alexandra , Ciudin Valentin Petre , Crauciuc Dragos , Buhas Camelia Liana , Manoilescu Irina Smaranda , Solovastru Laura Gheuca , Ioan Beatrice Gabriela
Published: February 2020

The natural course of evolution of the human body after death includes autolysis, putrefaction and skeletonization. Under specific environmental conditions, the body may bypass this natural path, leading to preservation, such as saponification (adipocere), lignification, mummification or refrigeration, comprising the entire body or being limited only to some parts of it. All these preservation processes have a chemical substrate, and the identification of their components may be useful in many forensic circumstances, such as clandestine activity and identification of victims in mass disasters, when pentanoic, butanoic, hexanoic acid, butanoic acid-butyl ester, hexanoic acid-ethyl ester, indole, dimethyl disulphide may be used to train human remains detection dogs. The authors present the case of a 73 years old woman who was found dead in a sewage collection basin 4 months after her disappearance in July. The autopsy revealed a mixture of cadaveric processes, some parts being disintegrated, with putrefaction and skeletonization, while other parts were preserved by saponification: areas of adipocere were found on the neck, thorax and the anterior part of the abdomen. In some instances the saponification of the corpses makes identification possible and preserves violence marks, but the combination with putrefaction burdens these goals. The identification in this case was possible using the teeth formula, keeping in mind that tooth and bones are the most resistant to putrefaction. Even though saponification makes difficult the estimation of postmortem interval, investigations of its chemical composition may be useful in this direction, as the epicoprostanol-cholesterol ratio proved to increase with the increasing of postmortem interval.
Parameters of Chemical Composition of Phaseolus coccineus L. Pods Grown in Protected Areas
Authors: Avasilcai Liliana , Teliban Gabriel , Morariu Daniela Ionela , Stoleru Vasile , Bibire Nela , Vieriu Madalina , Panainte Alina Diana , Munteanu Neculai
Published: February 2020

Runner beans are an important source of carbohydrates, fibers, vitamins and minerals that play an important part in the cardiovascular and gastrointestinal tract physiology. The aim of the study was the identification of crop specificities of four varieties of Phaseolus coccineus L. homologated in the Great Britain: Lady Di, Desiree, Polestar and White Apollo, which are less cultivated in Romania, although during the study they proved a remarkable crop production. Another objective of the study was the determination of some chemical composition parameters of the pods harvested from protected areas, in order to highlight the particularities that could determine the expansion of their cultivation in our country.
The Association Between Stress Level and Laboratory Parameters, Sex, Age and Stage Disease in Patients with Digestive and Bronchopulmonary Neoplasms
Authors: Calborean Veronica , Gheorman Victor , Namat Razan Al , Cazacu Irina Mihaela , Varju Peter , Gede Noemi , Streba Costin Teodor , Vere Cristin Constantin , Gheonea Dan Ionut , Gheorman Valeriu , Lungulescu Cristina , Lungulescu Cristian Virgil
Published: February 2020

We conducted a prospective study to determine whether there is a possible correlation between stress level and age, sex, cancer site, disease stage and to explore whether stress level changed during each visit. Patients diagnosed with digestive or bronchopulmonary neoplasms over a period of 6 months were included in our study. The level of stress for each patient was investigated using a questionnaire developed by an authorized psychiatrist. The questionnaire comprised 10 items and the score for each component ranged from 0 to 3, a higher score indicating a higher level of stress. For the purpose of this study, a score ] 20 indicated a high level of stress. Each patient included in our study completed the questionnaire during three consecutive visits in our department. Our study revealed a statistically significant association between age and stress level, whereas no correlation was found between stress level and laboratory parameters, tumor site and disease stage.
Preliminary Study on Assessment of Mineralization Degree and Nutrient Content of Groundwater Bodies in Gorj County
Authors: Cirtina Daniela , Capatina Camelia
Published: February 2020

The research study performed aims to assess the degree of mineralization and nutrient contents of groundwater bodies in Gorj County in the period 2014-2015 based on the monitoring indicators such as: pH value, electrical conductivity, chlorides content, sulphates, nitrates, nitrites, phosphates, ammonium, sodium and potassium ions. Samples of waters were taken from eight wells located in depth groundwater bodies, code ROJi05 and ROJi08 in order to determine the mineral and nutrient contents. All the indicators monitored were taken into account for assessing the mineralization degree of groundwater. The values of monitored indicators of groundwater were within the allowed limits for drinking water according to Law 458/2002 amended by Law no. 311/2004 regarding the drinking water quality with the exception of sulfur content. The values of nutrient content exceeded the allowed limits for sulphates, nitrate, nitrite and ammonium.
The Dynamics of the Main Oxidative Stress Chemical Markers in the Serum of Rats Stressed by Various Behavioural Tasks
Authors: Alexa Anisia Iuliana , Cantemir Alina , Antioch Iulia , Balmus Ioana Miruna , Cojocaru Sabina , Gardikiotis Rodica , Luca Andrei , Filip Mihai-Andrei , Ababei Daniela Carmen , Zamfir Carmen Lacramioara
Published: February 2020

Oxidative damage is a biochemical event currently incriminated in the occurrence of many disorders. The range of affections varies, from psychiatric illnesses, like depression, schizophrenia, Alzheimer�s disease, for instance, to somatic disorders such as carcinogenesis or diabetes. Moreover, ophthalmological pathology is also affected in their development by the oxidative stress factor. In the present study, we focused on following the changes which occur in the serum of rats exposed to environmental stress conditions (swimming and treadmill exercises) by determinations of superoxide dismutase (SOD), glutathione peroxidase (GPX) specific activity and malondialdehyde (MDA) concentration. There are important biomarkers of oxidative stress, suspected to play a relevant role in the pathology of dry eye syndrome. Our preliminary oxidative stress analysis of the serum, sampled from animals exposed to physical stress in attempt to induce dry eye syndrome pathology, showed that the levels of SOD and GPX enzymes were higher as compared to controls. Also, MDA concentration was decreased with a significant value attributed to the swimmer rats compared to controls.
S53P4 Bioactive Glass - an Alternative Treatment of Bone Defects
Authors: Trambitas Cristian , Pop Tudor Sorin , Trambitas Miron Alina Dia , Dorobantu Dorin Constantin , Brinzaniuc Klara
Published: February 2020

A challenging problem in orthopedic practice is represented by bone defects may they occur from trauma, malignancy, infection or congenital disease. Bioactive Glasses have a widely recognized ability to foster the growth of bone cells, and to bond strongly with both hard and soft tissues. Upon implantation, Bioactive Glasses undergoes specific reactions, leading to the formation of an amorphous calcium phosphate or crystalline hydroxyapatite phase on the surface of the glass, which is responsible for its strong bonding with the surrounding tissue. This phenomenon sustains a more rapid healing of bone defects and presents great antibacterial properties. In this paper we report on a clinical study that uses S53P4 Bioactive Glass to successfully treat bone defects and testify of the good compatibility of this material with human tissues.
Docking Study of 3-mercapto-1,2,4-triazole Derivatives as Inhibitors for VEGFR and EGFR
Authors: Mioc Marius , Avram Sorin , Tomescu Andrei Branco , Chiriac Daniela Veronica , Heghes Alina , Voicu Mirela , Voicu Adrian , Citu Cosmin , Kurunczi Ludovic
Published: February 2020

Computer-aided drug design plays an important role in modern day drug discovery, because it provides a more specific range for active compound chemical synthesis in detriment of the traditional ways of drug discovery. Relevant studies proved that the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are important targets for inhibition, in finding new molecules with potential anticancer activity. The aim of the present study was to create a compound library and submit this set of molecules to a docking-based virtual screening process. Molecular docking was carried out using OEDocking HYBRYD, a software with an improved scoring algorithm, which uses a ligand-based scoring function. The obtained results revealed some molecular structures that showed good predicted binding affinity towards their respective protein targets.
Remineralization of Natural Tooth Enamel in Artificial Saliva Environment
Authors: Zaharia Agripina , Plescan Viorica Ghisman , Atkinson Irina , Mocioiu Oana Catalina , Cantaragiu Alina , Musat Viorica
Published: February 2020

This paper investigates in situ remineralization of the acid-etched natural enamel surface, by incubation in a phosphate solution with neutral pH, at 37 �C for 4-10 days, without using any enamel matrix derivative (EMD). We investigated the morphology, crystallinity, chemical composition and structure of the newly grown layer onto the natural enamel surface stored in contact with artificial saliva (AS) having a composition similar to natural oral environment. The crystalline phases, crystallite size and orientation, as well as the chemical and phase composition of the remineralized dental enamel samples were studied by scanning electron microscopy coupled with energy dispersive X-ray spectrometry, Fourier transform infrared spectroscopy and X-ray diffraction. The experimental results showed that the enamel crystals grown on the demineralized enamel surface are mainly Ca-deficient apatite hexagonal structure. Fluoridated hydroxyapatite and sylvite-type KCl crystallites, which amount considerable increased in the case of sample stored in AS for 10 days, were also identified.