bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic Analysis of Early Phosphorylated Proteins in Acute Pancreatitis
Model
Authors: Xiao Juan , Zhang Pengcheng , Zhou Yuan , Fang Qiangqiang , Lin Houmin
Published: December 2021

Background and Objective:

The exact mechanism of acute pancreatitis (AP), which is an inflammation of the pancreas, still remains unclear. In this study, we examined the protein phosphorylation changes during the early stage of AP in mice using proteomic analysis.

Methods:

AP model in mice was constructed using an intraperitoneal injection of cerulein. Blood samples and pancreas were collected at 1, 3, 6, 9h after the final injection (n=3 at each time point). Samples collected 3h after the final injection were separately mixed and named S (saline group) and C1 (cerulein group); samples collected 6h after the final injection from the cerulein group were mixed and named C2. Proteins from S, C1, and C2 were extracted, digested by trypsin, and subjected to LC-MS/MS analysis, bioinformatics analysis, and Western blotting.

Results:

A total of 549 sites (426 proteins) were upregulated, and 501 sites (367 proteins) were downregulated in C1 compared to S; while 491 phosphorylation sites (377 proteins) were upregulated and 367 sites (274 proteins) were downregulated in C2 compared to S. Motif analysis showed that proline-directed kinase and basophilic kinase had a key role during early AP. During an early AP stage, the cellular distributions of proteins slightly changed. The types of domains changed with the development of AP. Phosphorylation proteins associated with calcium signaling, especially IP3R mediated calcium release, lysosome and autophagosome pathway, pancreatic digestive activation, and secretion, were found to be involved in the development of early AP independent of NF-kB activation. Moreover, the MAPK family was found to have a greater impact at the early stage of AP. We also found differentially expressed phosphorylations of amylase and trypsinogen and increased phosphorylation of MAPK6 S189 in early AP.

Conclusion:

IP3R mediated calcium release and activation of MAPK family are key events promoting the development of early AP.
Functional Disability among Systemic Sclerosis Patients: Relation to Disease
Characteristics and Quality of Life Parameters
Authors: Zaghlol Rabab S. , Dawa Ghada A. , Makarm Wafaa K.
Published: December 2021

Background:

Disability in patients with scleroderma (SSc) has been associated with
poor health-related quality of life (HRQoL) in all dimensions, including physical, psychological,
and social dimensions.

Objective:

This study was conducted to examine different factors that may be associated with functional
disability and poor HRQoL, with the aim of targeting these factors in the future to improve
physical activity, functional outcomes, and HRQoL.

Methods:

A single-center cross-sectional study was conducted on 38 patients with SSc to compare
characteristics between patients with and without disability using the Health Assessment Questionnaire
Disability Index (HAQ-DI). Quality of life was assessed using the Short Form-36 (SF-36).
Linear regressions were performed to examine variables contributing to functional disability.

Results:

Almost 65.78% (n = 25) of patients in the study group reported functional disability. The
presence of functional disability was associated with reduced HRQoL, as reflected by physical
function (P = 0.0001), physical role (P = 0.016), bodily pain (P = 0.001), general health
(P = 0.002), social functional (P = 0.002), emotional role (P = 0.042), and mental health (P = 0.025)
domains of the SF-36 score. Multiple linear regression indicated that the main predictive factors associated
with HAQ-DI were the modified Hand Mobility in Scleroderma, modified Rodnan skin
score, DIstance walked in 6 minutes, BOrg dyspnea index, and SAturation of oxygen at 6 minutes
(DIBOSA), and Fatigue Severity Scale among patients with SSc.

Conclusion:

In patients with SSc, recognizing the relationships between clinical findings and functional
disability will allow the development of further management strategies to minimize disease
severity and enhance HRQoL.
Type I Diabetes Mellitus and Insulin Therapy on Bone Microarchitecture,
Composition and Mechanical Properties
Authors: Dechichi Paula , Limirio Pedro Henrique Justino Oliveira , Soares Priscilla Barbosa Ferreira , Venâncio Jessyca Figueira , Rabelo Gustavo Davi , Soares Carlos José
Published: December 2021

Background:

The aim of this study was to evaluate the microarchitecture, composition
and mechanical properties of cortical bone of rats with type I diabetes mellitus (TIDM) and submitted
to insulin therapy (IT).

Methods:

Thirty rats were divided into three groups (n=10): non-diabetic, diabetic and diabetic+insulin.
TIDM was induced by intravenous injection of streptozotocin. In diabetic+insulin group, 4IU
insulin was administered twice per day (1I U at 7 am and 3I U at 7 pm). The animals were euthanized
five weeks after TIDM induction; the tibiae were removed and submitted to microcomputed
tomography (micro-CT, 8 μm), fourier transform infrared spectroscopy (FTIR) and dynamic microhardness
indentation.

Results:

Micro-CT analysis showed that diabetic group had lower bone surface/tissue volume ratio
(BS/BV) (p=0.018), cortical thickness (Ct.Th) (p<0.001) and degree of anisotropy (Ct.DA)
(p=0.034) values compared to non-diabetic group. The diabetic group showed lower Ct.Th than diabetic
+ insulin group (p=0.018). The non-diabetic group had lower fractal dimension (Ct.FD) values
compared to diabetic groups (p<0.001). The ATR-FTIR analyses showed lower values for all
measured parameters in the diabetic group than the non-diabetic group (amide I ratio: p=0.046;
crystallinity index: p=0.038; matrix:mineral ratios - M:MI: p=0.006; M:MIII: p=0.028). The diabetic+
insulin group showed a lower crystallinity index (p=0.022) and M:MI ratio (p=0.002) than nondiabetic
and diabetic groups, respectively. The diabetic group showed lower Vickers hardness values
than non-diabetic (p<0.001) and diabetic+insulin (p=0.003) groups.

Conclusion:

TIDM negatively affects bone microarchitecture, collagen maturation, mineralization
and bone microhardness. Moreover, insulin minimized the effect of TIDM on cortical thickness
and organic/mineral matrix.
Current Research on Pro-drug Therapies for Parkinson's and Alzheimer's Disease
Authors: Huo Cui , Wu Lei , Jiang Zhiqiang , Yang Jiacheng , Wang Zhouyu , Li Yuzhi , Qian Shan
Published: December 2021

Background:

Alzheimer's disease (AD) and Parkinson's (PD) disease are common neurodegenerative
conditions of the Central Nervous System (CNS). Thus, these diseases have only been
treated symptomatically since no approved drug is available that provides a complete cure.

Objectives:

Through reading relevant literatures published at home and abroad, the method and significance
of prodrug strategy to increase the efficacy of ad and pd drugs were discussed.

Methods:

The biological mechanisms and currently approved drugs for both diseases have been discussed,
revealing that most of these treatments utilized existing prodrug design strategies, including
increased lipophilicity, and the use of transporters mediation and bio-oxidation to improve oral bioavailability
and brain permeability.

Results:

The purpose of this paper is to review the research progress in the treatment of Neurodegenerative
Diseases (NDDS), especially ad and pd, using the prodrug strategy. The research of drug
bioavailability and the prodrug strategy of cns targeted drug delivery lay the foundation for drug
development to treat these diseases.

Conclusion:

The use of prodrug strategies provides important opportunities for the development of
novel therapies for ad and pd.
Diabetes Induced Factors Prediction Based on Various Improved Machine
Learning Methods
Authors: Wu Jun , Qu Lulu , Yang Guoping , Han Nan
Published: December 2021

Background:

With the increasing quality of life of people, people have begun to have more
time and energy to pay attention to their own health problems. Among them, diabetes, as one of the
most common and fastest-growing diseases, has attracted widespread attention from experts in bioinformatics.
People of different ages all over the world suffer from diabetes, which can shorten the life
span of patients. Diabetes has a significant impact on human health, so that the accuracy of the initial
diagnosis becomes essential. Diabetes can bring some serious complications, especially in the elderly,
such as cardiovascular and cerebrovascular diseases, stroke, and multiple organ damage. The initial diagnosis
of diabetes can reduce the possibility of deterioration. Identifying and analyzing potential risk
factors for different physical attributes can help diagnose the prevalence of diabetes. The more accurate
the prevalence, the more likely it is to reduce the incidence of complications.

Methods:

In this paper, we use the open source NHANES data set to analyze and determine potential
risk factors relevant to diabetes by an improved version of Logistic Regression, SVM, and other improved
machine learning algorithms.

Results:

Experimental results show that the improved version of Random Forest has the best effect,
with a classification accuracy of 92%, and it can be found that age, blood-related diabetes, high blood
pressure, cholesterol and BMI are the most important risk factors related to diabetes.

Conclusion:

Through the proposed method of machine learning, we can cope with class imbalance and
outlier detection problems.
Non-Alcoholic Fatty Liver Disease and Hypothyroidism: Review of Clinical and Experimental Studies
Authors: Ranhulova Tetiana
Published: December 2021

Hypothyroidism is a widespread condition affecting people of different socio-economic background and geographical location. A lot of studies highlight the effect of hypothyroidism on the metabolic processes in various organs, including the liver. On the other hand, liver damage often results in the development of non-alcoholic fatty liver disease; however, the data on the impact of hypothyroidism on liver morphology, which can serve as a direct indicator and marker of liver condition and function, are limited and controversial. In this report, we reviewed the relationship between non-alcoholic fatty liver disease and hypothyroidism with an accent on morphological alteration of the liver discovered in clinical and experimental studies.
Vaccination of adult patients living with chronic kidney disease against SARS-CoV-2: a position statement by the South African Nephrology Society
Authors: Davies Malcolm , van Hougenhouck-Tulleken Wesley , Diana Nina E , Chothia M Yazied , Nel Jeremy , Wearne Nicola , Wadee Shoyab , Hariparshad Sudesh
Published: December 2021

Safe and effective vaccination of patients living with chronic kidney disease requires an understanding of the unique immunological milieu of this population and of their potential for disease-specific side effects. This Position Statement, issued on behalf of the South African Nephrology Society, provides recommendations for local policy development and for individual practice administration and monitoring of SARS-CoV-2 vaccinations in patients living with chronic kidney disease.
Elements That Underpin the Design, Development, and Evaluation of Social Media Health Interventions: Protocol for a Scoping Review
Authors: Nizam Mohammed Zayan , Powell Leigh , Zary Nabil
Published: December 2021

Background

Social media use has grown tremendously over the years. Given the volume and diversity of people on social media and the amount of information being exchanged, it is perhaps unsurprising that social media is being used as an avenue to disseminate and deliver health interventions. There exists an opportunity for social media health interventions to make a positive impact on health. However, there is a need to understand more about the ways in which these interventions are designed, developed, and evaluated. This scoping protocol will review the current state of this field by charting the elements that drive the design, development, and evaluation of these interventions. This includes charting models, frameworks, and rationales for the interventions, as well as the platforms being used, and the health behaviors being targeted. This intention of this scoping review is to help inform those who wish to develop effective social media health interventions.

Objective

The objective of this review is to map the elements that drive the design, development, and evaluation of social media health interventions. We define “social media health intervention” as interventions that make use of social media platforms to disseminate or deliver health-related information and educational initiatives to the public. We will seek to chart the elements that drive the design, development, and delivery of such interventions, including their platforms and targeted health behaviors.

Methods

The methodological framework for this review is guided by Arksey and O’Malley and enhancements by later studies. We will search relevant literature from 9 databases: (1) PubMed, (2) PsycINFO, (3) EMBASE, (4) Web of Science, (5) Scopus, (6) CINAHL, (7) ERIC, (8) MEDLINE, and (9) Google Scholar. The literature will be screened by at least two reviewers in 2 stages: (1) title/abstract screening against the eligibility criteria; and (2) eligible articles will then undergo a full-text screening. Data will be charted using the data charting tool developed by the authors.

Results

The results of this study will be presented in a final scoping review paper, divided into 2 sections. The first section will describe the search strategy and study selection process and will contain the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. The second section will provide key details pertaining to the review objective and question.

Conclusions

This review will help guide scholars looking to build social media health interventions toward evidence-based practices in design and evaluation.

International Registered Report Identifier (IRRID)

PRR1-10.2196/31911
The Dichotomy of Intimate Garments: Women’s Stays and Pockets in Georgian Britain
Authors: Cotton Cornwall Olivia
Published: December 2021

In John Collet’s 1777 print, Tight Lacing, or Fashion Before Ease a woman is depicted holding onto a bed poster as her maid and husband strain to tighten the lacing on her stays. Meanwhile, a large tie-on pocket can be seen hanging from the woman’s waist. Although they were worn closely together on the female body stays and pockets have been studied independently from each other. This is understandable, as at first glance, they appear incomparable. Stays were the precursor to nineteenth century corsets and they moulded the body into the desired and fashionable shape. Pockets on the other hand were utilitarian bags meant for carrying necessary items; separate from women’s clothing they were tied around the waist with string and were hidden under the skirts. Despite the initial differences, these garments did not function independently from each other. Using caricatures, etiquette books, and physical examples found in museum collections, this study demonstrates that when examined in tandem it becomes apparent that stays and pockets served distinct, yet overlapping functions in women’s lives. They informed women’s relationships with their surrounding environments, strengthened women’s connection to the domestic realm, yet also gave women freedom to move outside the home and participate within the public sphere. Furthermore, both items also acted as private spaces, which allowed women to actively partake in romantic courtship and sexual flirtations in a gender appropriate way. By juxtaposing stays and pockets this study contributes to the growing historical discussion surrounding these items, but also begins to piece together a larger picture of the role undergarments, as a whole, played in women’s lives.
Primary investigating chemical constituents of bioactive extract from Centrostachys aquatica (R.Br.) Wall. ex Moq.-Tand.
Authors: Ngo Quoc Luan , Ta Thao Cuong , Tran Thi Manh Huynh , Le Minh Dan , Ngo Khac Khong Minh , Ngo Trong Nghia , Nguyen Diep Xuan Ky , Phan Nhat Minh , Nguyen Tan Phat
Published: December 2021

This study is aimed to screen the biological activities and chemical composition to find evidences for potential medicinal applications of Centrostachys aquatica in the Mekong Delta. Crude methanol extract and subextracts in n-hexane, ethyl acetate, and acetone from Centrostachys aquatica were tested bioactivities. The methanol extract, n-hexane and ethyl acetate subextracts exhibited antimicrobial activity with corresponding MIC values of 200, 100 and 200 µg/mL, respectively. The ethyl acetate subextract was inhibited cytotoxicity against cancer cell line LU-1 with IC50 of 27.66 µg/mL. None of the  extracts showed antioxidant ability. Three known secondary metabolites including oleanolic acid (1), 20(E)-hydroxy-b-ecdysone (2), and b-spinasterol (3) were isolated for the first time from the bioactive (ethyl acetate) subextract of Centrostachys aquatica. Their structures were elucidated by modern spectra as MS, NMR and comparison with published data.
Value chain and competitiveness of OCOP standardized clown knife fish products in Hau Giang province
Authors: Nguyen Thuy Trang , Vo Hong Tu
Published: December 2021

The study was conducted to analyze the competitiveness of OCOP standardized clown knife fish products in Hau Giang province. The data were collected from 73 observations involved in the clown knife fish value chain. The research results show that most farmers culture knife fish intensively and the feed cost shares the highest proportion of the total production cost. Processed products from knife fish are mainly boneless fish and fish balls. The OCOP knife fish value chain operated through four main distribution channels and included actors: fish farmers, traders, processors, and retailers. The farmers normally sell fresh knife fish to middleman, accounting for 80.15%. The processing factories create and share the highest proportion of added value. The distribution channel that farmers are linked directly with processors create higher added value than others. The study also analyzed the Porter’s five forces of the knife industry. The study found that there are many potential risks in the farming process, high competitive pressures from substitute products, and limited negotiation ability of both farmers and processors.
Karakteristik sifat Fisik Kimia dan Organoleptik Tiwul Instan Protein Tinggi Bersubtitusi Tepung Koro Pedang (Canavalia ensiformis L.)
Authors: Herlina Herlina , Lindriati Triana , Nurhayati Nurhayati , Sulistyani Sulistyani , Hidayati Manik Nur , Utami Elok Sri , Soekarno Siswoyo
Published: December 2021

Penelitian ini bertujuan untuk mengetahui pengaruh persentase subtitusi tepung koro pedang pada pembuatan tiwul instan protein tinggi terhadap karakteristik fisik, kimia dan organoleptik tiwul instan dan menentukan persentase subtitusi tepung koro pedang yang tepat sehingga dihasilkan tiwul instan yang disukai. Penelitian ini dilakukan dengan Rancangan Acak Lengkap (RAL) faktor tunggal, yaitu persentase subtitusi tepung koro pedang pada pembuatan tiwul instan dan setiap perlakuan dalam penelitian diulang 3 (tiga) kali. Data pengamatan yang didapatkan dianalisis menggunakan uji keragaman (ANOVA) taraf kepercayaan 95% (α≤0,05) dan apabila ada perbedaan yang nyata antar perlakuan (α≤0,05) dilanjutkan dengan uji beda Duncan. Data uji organoleptik dianalisis menggunakan uji chi-square (α≤0,05). Hasil penelitian ini menunjukkan, bahwa peningkatan persentase subtitusi tepung koro pedang menyebabkan peningkatan daya rehidrasi, daya kembang dan kadar protein tiwul instan protein tinggi, namun menyebabkan penurunan terhadap densitas kamba, kecerahan warna dan  kadar air tiwul instan protein tinggi yang dihasilkan. Uji organoleptik kesukaan panelis didapatkan persentase tertinggi pada perlakuan P3 (persentase subtitusi tepung koro pedang 30% ) dengan atribut memiliki daya rehidrasi 347%, densitas kamba 0,51 g/mL, daya kembang 35,14%, kecerahan warna 69,87, kadar air 6,05%, dan kadar protein 8,15%, serta persentase kesukaan warna, aroma, rasa, tekstur, dan kekenyalan berturut turut 56, 40, 62, 68, dan 64%.
Characterization of Old Nipah (Nypa fruticans Wurmb) Fruit Endosperm Flour and Its Application for Gluten-Free Cookies
Authors: Nofiani Risa , Romengga Jorion , Zaharah Titin Anita
Published: December 2021

Old nipah fruit endosperms (ONFEs) contain high carbohydrates that have a potency to be applied to make flour. In this study, we made flour from ONFEF and its cookies. This study aimed to characterize the functional properties of unbleached and bleached old nipah fruit endosperm flour (UONFEF and BONFEF) and to assess the consumer acceptability of ONFEF flour and gluten-free cookies made from UONFEF and BONFEF. UONFEF and BONFEF were prepared from the ONFEs. They were cut, dried and ground, and sieved to obtain the UONFEF. TheUONFEF was bleached using Na2S2O5 0.4% for 15 mins then filtered, and the precipitates were dried under the sun. The dried precipitates were sieved to obtain the BONFEF. Both of the flour types were analyzed in terms of their functional properties (bulk density, swelling power, solubility, swelling capacity, water absorption index, and viscosity) and were used to make gluten-free cookies. The following ingredients were prepared to make the the gluten-free cookies: 200 g of flour (each of the UONFEF, BONFEF, and commercial wheat flour (CWF, Segitiga Biru brand) as a control), 100 g of margarine, 60 g egg, 125 g of fine granulated sugar, and 2 g of vanillin. Margarine, egg, and fine granulated sugar were mixed using a hand mixer and added with the flour, blended, molded, then baked. Consumer’s acceptability of each type of flour and cookies from different types of flour was evaluated using semi-trained panelists. The bleached treatment (the BONFEF) caused differences of the flour, particularly in terms of the physical properties (particle size, color, and odor) from the unbleached treatment and rated thehighest score for the overall criteria. Besides, the functional properties of the UONFEF were significantly different (p < 0.05) from those of the BONFEF except for the rendement, SP, and viscosity. The gluten-free cookie made from the UONFEF was the most preferred by the panelists. Therefore, the UONFEF can be successfully used as a substitute flour of wheat flour to make cookies.
HOLOEXPO 2021
Authors: Истомина Н.Л.
Published: December 2021

20–23 сентября 2021 в Геленджике Краснодарского края прошла XVIII Международная конференция по голографии и прикладным оптическим технологиям HOLOEXPO 2021. Конференция охватывала следующие тематики: современные тенденции развития голографии и прикладных оптических технологий; защитная голография и прикладные защитные оптические технологии; голограммная оптики и дисплеи дополненной и виртуальной реальности; компьютерная голография, голограммные и дифракционные оптические элементы, метаматериалы и нанотехнологии; объемная голография и голографические фотоматериалы; цифровая голография, оптико-­голографическая обработка информации, голографическая интерферометрия, голографическая память.
Экспериментальные исследования волоконного конфокального датчика на основе метода хроматического кодирования
Authors: Завьялова М.А. , Завьялов П.С. , Савченко М.В.
Published: December 2021

В работе представлены результаты экспериментальных исследований волоконного конфокального датчика на основе метода хроматического кодирования с разработанными гибридными рефракционно-­дифракционными и гиперхроматическими объективами. Данный датчик позволяет определять положение контролируемых поверхностей с высоким разрешением (погрешность не превышает 0,1–1 мкм) на рабочих отрезках от 20 до 220 мкм.
Получение анизотропных магнитных порошков системы "неодим – железо – бор" с высокими магнитными свойствами на укрупненной опытной установке
Authors: Глебова Е.М. , Моломин В.И.
Published: December 2021

Исследование проводилось на высокоэрцитивных анизотропных порошках из сплавов системы Nd-Fe-B, полученных HDDR-методом. Доказана возможность проведения HDDR-процесса в большом объеме обрабатываемого магнитного порошка, изготовлена опытная партия и определены его магнитные характеристики.
СЕТИ 5G: ОБЕСПЕЧЕНИЕ КОНФИДЕНЦИАЛЬНОСТИ И БЕЗОПАСНОСТИ. ЧАСТЬ 1
Authors: Коган С.
Published: December 2021

Современные операторы сетей, поставщики контента и услуг должны соблюдать требования безопасности, которыми регулируются управление и защита конфиденциальных данных от раскрытия, кражи и неправомерного использования. Количество конфиденциальных данных, генерируемых компаниями и частными пользователями, неуклонно растет. Традиционно хранящиеся и обрабатываемые на месте данные в настоящее время транспортируются через общие сетевые ресурсы, зачастую через глобальную сеть. Широкое использование виртуальных объектов и облачных сетей создает новые угрозы уязвимости сети к внешним атакам. Безопасность − одно из важнейших преимуществ 5G, которые будут служить критически важной инфраструктурой для оцифровки, автоматизации и подключения к машинам, роботам, к управлению транспортными средствами и т. п. В статье рассмотрены вопросы обеспечения безопасности и защиты конфиденциальных данных при оказании телекоммуникационных услуг на базе сетей 5G. В первой части материала основное внимание уделено теме международной стандартизации обеспечения безопасности телекоммуникационных сетей.
Real-Time Sign Language Detection and Recognition
Authors: Sharma Sarthak
Published: December 2021

Abstract: Sign language is one of the oldest and most natural form of language for communication, but since most people do not know sign language and interpreters are very difficult to come by we have come up with a real time method using neural networks for fingerspelling based American sign language. In our method, the hand is first passed through a filter and after the filter is applied the hand is passed through a classifier which predicts the class of the hand gestures.
Studies on the Effect of Extracts of Aromatic Plants on Fungal Growth
Authors: Thomas Jiji
Published: December 2021

Annotation: Article describes Bio-control of pathogenic fungi Keywords: Anti-fungal, Medicinal, Aromatic Plants
Swedish baron G.M. Sprengtporten in Russian service, 1786-1809
Authors: Shaidurov Vladimir N. , Veremenko Valentina A.
Published: December 2021

General of the Infantry Count G.M. Sprengtporten (1740-1819) is one of the less known historical figures of the last quarter of the 18th and of the early 19th century. As a Swedish citizen, he hatched plans to turn Finland into an independent state. In the mid-1780s he saw in Catherine II a potential ally who could implement his ideas. After accepting the invitation to enter Russian service, Sprengtporten did not blend either in the Highest Court or in the Russian army. Not having shown any significant military feats during the wars of the late 18th and early 19th centuries, he distinguished himself in the diplomatic and lawmaking field. An important event was his mission to Europe (1800-1801), which resulted in the return of more than six thousand Russian prisoners to Russia. The draft Regulations on the Establishment of the Main Administration in New Finland, developed by Sprengtporten with some changes made by Emperor Aleksander I, became the cornerstone of Finnish autonomy within the Russian Empire over the next century. Occupying for a short time the post of Governor General, he became a link between Finland and Russia. The scientific novelty of the article lies in the comprehensive presentation of the Russian service of G.M. Sprengtporten. The article is written on the basis of published sources and unpublished documents from some central archives, which are introduced into scientific circulation for the first time.
Projects of the South of Russia’s Government on the development of urban self-government in the White Crimea, October - November 1920
Authors: Tsvetkov Vasiliy Zh.
Published: December 2021

The article studies the development of an economic and political-legal basis for the development of urban self-government under General Wrangels Government of the South of Russia, in the Crimea, in the autumn of 1920. From among the Wrangel governments reforms in the Crimea in 1920, transformations in the sphere of urban life and urban self-government are less well-known than transformations in agrarian policy and the zemstvo reform. But changes in the operation of city dumas and city administrations are no less relevant for Russian historiography. The article considers the specifics of the evolution of municipal law in a situation where it was hoped that the offensive of the Red Army at Perekop could be beaten back. The article notes the importance of changing the legislative framework regarding the expansion of the powers of city self-government not only in the social, political, but also in the economic sphere. First of all, this was manifested in the field of granting the right to impose taxes and fees by city structures. The article discusses the prospects that an increased role of city self-government was supposed to have on economic and political decisions by the Wrangel government. The analysis includes the supposed forms of cooperation between the White power and the public in the 1920s. Special attention is paid to the problems that were considered at a specially convened congress of city self-government in Simferopol, on the eve of the Perekop-Chongar operation. The decisions taken during this congress were supposed to strengthen the financial situation of the Crimea. The article also examines the interaction between the authorities of the Wrangel government and the local population during the military-political crisis of the White Movement in the autumn of 1920.
The sentiments of the population in Vladimir Region during the Great Patriotic War
Authors: Tryakhov Ilya S.
Published: December 2021

The article examines the mood of home front workers during the Great Patriotic War based on the materials of Vladimir region, a region that had its own specific features. The author draws attention to the change in the rear position of this territorial unit during the war. The sources for the analysis were archival documents, some of which are introduced into scientific circulation for the first time, as well as documents of a memoir and epistolary nature. The study of Soviet propaganda during the indicated period draws attention to the transition from predominantly internationalist to patriotic slogans - a process that started at the very beginning of the war, with some precedents already in the last pre-war year. In the course of the study, the author identifies the ambiguous sentiments of the population in the rear in relation to the war and their living conditions. Attention is drawn to the fact that citizens had a negative perception of a number of actions of the authorities in the initial period of the war. The article tells the difficult situation in the rear during the battle for Moscow, a victory which to a large extent caused a turn in the mood of the majority of the population. An analysis of the letters of front-line soldiers and home front workers clearly reveals the fatalism of most of them, and their submissive adherence to their prescribed fate. At the same time, their letters show the hope for a quick victory over Nazism and the belief that their closest descendants would be able to build a bright future. Despite the predominantly patriotic statements, the example of the Vladimir region shows a critical attitude towards the Soviet government, not only on regional but also on central level. Still, one cannot but confirm that Soviet propaganda was very successful in consolidating the people during the war, which was of course facilitated by the policy of Nazi Germany both at the front and in the temporarily occupied territories.
The Nenets Autonomous Okrug in the system of Russian federalism: an ethno-sociological investigation
Authors: Zorin Vladimir Yu. , Kamenskikh Mikhail S.
Published: December 2021

The article is devoted to the analysis of trends in the development of modern Russian federalism, against the background the discussions about a possible merger of the Nenets Autonomous Okrug (NAO) and the Arkhangelsk Region. These discussions caused mass protests among the residents of the Nenets Autonomous Okrug. In 1993, the NAO was proclaimed as an equal subject of the Russian Federation. However, the Okrugs historical dependence on the Arkhangelsk Region in terms of transport and energy caused difficult relations between the two regions over the past 30 years. In this regard, the situation in the Okrug is of interest from the standpoint of analyzing trends in the development of Russian federalism. In 2020, the situation around the NAO and the Arkhangelsk Region came back on the agenda after the announcement of the upcoming merger of the subjects. Mass protests, and the refusal of the majority of the district's population to support the amendments to the Constitution of the Russian Federation, suspended the process of regional integration. The main source of the study are data won from an ethno-sociological study conducted in the district in 2020. The study included questionnaires, focus groups and in-depth interview recordings. The material shows that despite the decision, the population of the district and public opinion leaders find an integration of the district and the Arkhangelsk region into one subject inacceptable. Moreover, the idea is perceived by many people as a threat, an attempt to conquer, invade. The participants of the survey give a negative assessment of the actions of the Arkhangelsk region authorities and support representatives of the district authorities that are against the integration. At the same time, the residents of the Okrug share the values of civil Russian identity and are ready to dialogue and compromises. The authors suppose that now it is essential to develop a flexible strategy and take into consideration the situation that has emerged recently. In the short term, it is necessary to involve broad strata of public opinion leaders in discussion and cooperation, study their sentiments, and take their position into account when studying the feasibility of new regions. It is necessary to involve the expert community in the development of the strategy.
Review of Moscow’s Evolution as a Political Space: From Yuri Dolgorukiy to Sergei Sobyanin, by Marina Glaser, and Ivan Krivushin. Cham: Palgrave Macmillan, 2021. 158 p.
Authors: Ivleva Marina L.
Published: December 2021

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Assessment of microbial biomass pool in chronosequence coal mine spoil used as biomarker of mine spoil genesis
Authors: Payal Agrawal , Jitesh Kumar Maharana , Amiya Kumar Patel
Published: December 2021

Extensive coal mining activities result mine spoil generation dumped in form of overburdens altering biogeochemical cycles and land degradation. Mine spoil generated after post-mining activities associated with heavy metal toxicity inhibit microbial growth. Being deficient in available nutrients due to lack of biologically rich topsoil, mine spoil represents a disequilibrated geomorphic system and poses problems for revegetation and restoration of coal mine spoil. Mine spoil genesis influencing ecosystem functionality demands physicochemical characterization and spatial distribution of microbial biomass pool in chronosequence coal mine spoil. Progressive improvement in clay, hydrological regimes, OC, TN and EP microbial biomass pool and BSR over time was evident from the study. Time dependent increase in integrating quotients was used to monitor the progress of mine spoil genesis. Decline in microbial metabolic quotient over time revealed the progress of mine spoil genesis. Stepwise multiple regression analysis revealed the contribution of physicochemical attributes influencing variability in microbial biomass. The shift in physicochemical properties and microbial biomass correlated well with the extent of land degradation, which can be used as effective biomarkers for monitoring the pace and progress of mine spoil genesis. The fresh coal mine spoil to attain soil features of nearby forest soil through mine spoil genesis shall take approximately 29.15 years. The study paves the way of greater understanding not only in the direction to design appropriate management strategies for ecosystem restoration but also to improve soil quality for sustainable development.
Evaluation of Biofloc Technology for Astacus leptodactylus: Effect of Different Stocking Densities on Production Performance and Physiological Responses
Authors: Kaya Doğukan , Genç Ercüment , Güroy Derya , Dinçer Serhat , Harmanşa Yılmaz Bilgenur , Yavuzcan Hijran
Published: December 2021

The use of biofloc technology (BFT) in narrow-clawed crayfish (Astacus leptodactylus) culture for 45 days was evaluated by production performance and physiological status of crayfish. Four different stocking densities of crayfish were tested in BFT (20, 41.66, 62.5, and 83.33 individuals m-2). Water quality parameters were monitored to sustain desired levels for crayfish and biofloc management. The growth performance of narrow-clawed crayfish did not show any significant differences among the groups. However, the survival rate changed by the stocking density. Hemolymph indices represented by total hemocyte counts and relative abundance of hyalinocyte, semi-granulocyte, and granulocyte were not affected by different stocking densities. Overall hemolymph glucose and lactate levels of narrow-clawed crayfish reflected mild stress in response to BFT conditions. Hemolymph protein concentrations did not change by the stocking ratio in BFT. Hemolymph protein levels were in the normal range, indicating the healthy status of the individuals. The hepatopancreas histology was observed as a typical morphology for healthy crayfish in all stocking densities in BFT. Notwithstanding the relatively lower survival rate in higher stocking density of narrow-clawed crayfish, the results of the present research revealed that the adaptation of narrow-clawed crayfish to BFT conditions is promising for the crayfish culture.
Estudo comparativo entre limites radiográfico e histológico em ameloblastomas
Authors: Silveira Heloísa Emília Dias da , Barbachan João Jorge Diniz
Published: December 2021

The aim of this study was to analyse the presence of histological infiltrations of neoplastic cells within the bone, and compare the distance of these infiltrations with the radiografic limits of the ameloblastoma. For this purpose, six integral surgical samples, with identifiable radiographic limits of the tumor, sent to the Pathology Service of Dental School of the Federal University of Rio Grande do SuÌ, were processed. From the resuÌts obtained, can be concluded úat, alúough ameloblastoma presents well-defined radiographic limits, it is infiltrative from the histological view point. Infiltrations occurs at few and distinctive sites. varying in this study from 0.10 cm to 1.40 cm, related to the radiographic borders of the neoplasm.
Algunas reflexiones sobre la evaluación de los aprendizajes en el e-learning
Authors: Mora-Vicarioli Francisco Rafael
Published: December 2021

En el contexto actual donde la pandemia del COVID-19 del 2020 ha permeado todos los sistemas educativos a nivel mundial, se ha volcado la mirada a la educación a distancia y al e-learning como una opción viable para mantener los procesos de formación en los diferentes niveles. La evaluación de los aprendizajes resulta una temática de gran importancia para obtener el mayor aprovechamiento de los entornos virtuales de aprendizaje, lo cual implica conocer algunas precisiones conceptuales para la toma de decisiones en cuanto a la mediación y estrategias que se pueden llevar a cabo. Este artículo se basa en la revisión teórica que sustenta una investigación doctoral, la cual pretende profundizar sobre esta temática en el contexto de la Universidad Estatal a Distancia de Costa Rica a nivel de dos planes de estudio. El objetivo de este artículo es analizar las principales aportaciones del tema de la evaluación de los aprendizajes en el e-learning. Entre los aspectos más relevantes de los hallazgos están la importancia de la dimensión formativa de la evaluación de los aprendizajes, así como la necesidad del involucramiento de los estudiantes en la evaluación por medio de estrategias de aprendizaje colaborativo, todo esto tendiente a promover la autorregulación y la competencia de aprender a aprender.
Mangrove (Rhizophora sp.) Fruit Extract Inhibits Tumor Growth Factor (TGF)-β1 Expression in High Cholesterol Diet-Fed Rats
Authors: Hamidy Muhammad Yulis , Masdar Huriatul , Winarto Winarto
Published: December 2021

Background: Atherosclerosis is a major finding in cardiovascular disease. One of the pro-fibrotic cytokines that play an important role in the atherosclerosis process is Tumor Growth Factor (TGF)-β1, where the presence of high TGF-β1 secretion due to hypercholesterolemia will trigger excessive collagen matrix formation. Objective: To analyze Rhizophora sp fruit extract effect on TGF-β1 expression in high cholesterol diet-fed rats. Material and Methods: Eighteen 10-week-old rats weighing 150-200 g were used in this study. These animals were grouped into 3 groups, each consisting of 6 rats. Group A (normal control) is a group of rats that received a normal diet. Group B (atherogenic control) received a diet that induces atherosclerosis (atherogenic diet). This diet contains 2% cholesterol, 5% goat fat, 0.2% cholic acid and standard diet up to 100%. Atherogenic diet was given for 3 days, and on the first day this group also received vitamin D3 700,000 IU/kg. Group C (treated), apart from receiving an atherogenic diet, was also given Rhizophora sp fruit extract 500 mg/kg body weight. The Rhizophora sp fruit extract effect on TGF-β1 expression was evaluated by immunohistochemical procedure. The area of ​​the expression is calculated using the ImageJ. Results: The results of this study indicate that the expression of TGF-β1 is higher in the group receiving the atherogenic diet than the normal control group (17.3 vs. 8.9; P=0.000). Rhizophora sp fruit extract reduced this expression remarkably (17.3 vs. 11.4; P=0.001). Conclusion: Rhizophora sp fruit extract inhibits the the expression of TGF-β1 in high cholesterol diet-fed rats.
Andrej
Authors: Denisa Böserová
Published: December 2021

The table was created on the topic of waste and its impact. The material I was based on
is a reference to the global production of a large amount of waste that cannot be
select repeatedly.
Necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus
Authors: Hiramatsu Toshiki , Tobino Kazunori
Published: December 2021

We report a fatal case of methicillin-resistant Staphylococcus aureus
(MRSA)-induced necrotizing pneumonia that was refractory to adequate
vancomycin treatment (trough value, 13.1 µg/mL), drainage of a
hydropneumothorax, and veno-arterial extracorporeal membrane
oxygenation. MRSA infection can cause rapidly progressive disease with a
high case fatality rate, even with appropriate treatment.
Fontaine Progeroid Syndrome -- A Case Report
Authors: Lally Sinead , Walsh Nicola , Kenny Janna , Franklin Orla , Cotter Melanie , Richardson Sarah , McElligott Fiona , Finan Alan
Published: December 2021

Fontaine Progeroid Syndrome (FPS) is an autosomal dominant condition
caused by pathogenic variants in the SLC25A24 gene located on chromosome
1. Eleven cases have been described in the literature, with early
lethality in some. We discuss the clinical course of a patient from
birth until his death at 7 months.
Unresectable and chemoresistant conjunctival squamous cell carcinoma on xeroderma pigmentosum treated by salvage radiation therapy: A case report and a review of the literature
Authors: Mane Maimouna , Benkhaled Sofian , Gueye Latifatou , Eyenga Josephine Frederique Mendouga , Dieng Mamadou Moustapha , Gestel Dirk Van , Gaye Papa Macoumba
Published: December 2021

Radiotherapy, by its mechanism, has always been suspected to be
contra-indicated in patients with xeroderma pigmentosum, depriving them
of this very effective modality in the treatment of their cancers. As
these suspicions have still not been confirmed, the place of
radiotherapy should be reconsidered, while applying precautionary
principles.
Evolution of parasitoid host preference and performance in response to an invasive host acting as evolutionary trap
Authors: Kruitwagen Astrid , Beukeboom Leo , Wertheim Bregje , Doorn Sander van
Published: December 2021

The invasion of a novel host species can create a mismatch in host
choice and offspring survival (performance) when native parasitoids
attempt to exploit the invasive host without being able to circumvent
its resistance mechanisms. Invasive hosts can therefore act as
evolutionary trap reducing parasitoids’ fitness and this may eventually
lead to their extinction. Yet, escape from the trap can occur when
parasitoids evolve behavioural avoidance or a physiological strategy
compatible with the trap host, resulting in either host-range expansion
or a complete host-shift. We developed an individual based model to
investigate which conditions promote parasitoids to evolve behavioural
preference that matches their performance, including host-trap
avoidance, and which conditions lead to adaptations to the unsuitable
hosts. One important aspect of these conditions was reduced host
survival during incompatible interaction, where a failed attempt by a
parasitoid resulted in host killing. This non-reproductive host
mortality had a strong influence on the likelihood of establishment of
novel host-parasitoid relationship. Killing unsuitable hosts can
constrain adaptation under conditions which in fact promoted adaptation
when parasitoids would leave the trap host unharmed and survive
parasitoid attack. Moreover, our model revealed that host-search
efficiency and genetic variation in host-preference play a key role in
the likelihood that parasitoids will include the suboptimal host in
their host range, or will evolve behavioural avoidance resulting in
specialization and host-range conservation, respectively. Hence,
invasive species might change the evolutionarily trajectory of native
parasitoid species, which is important for predicting biocontrol ability
of native parasitoids towards novel hosts.
The concept of equilibrium in economics
Authors: Njegovan Nikola
Published: December 2021

Equilibrium models play a central role in modern (micro)economic analysis.
They form the basis of almost all our understanding in economics and are
increasingly being used in other fields of social science. Yet there are
numerous limitations to the equilibrium approach. To name a few: the
treatment of time, i.e., the problem of distinguishing between ?time in
models? and ?models in time?; learning process, i.e., the problem of
knowledge necessary to attain the equilibrium; equilibrium dynamics, i.e.
considering the equilibrium attainment process and not just the equilibrium
state. Many critics already drew attention to the reach and limitations of
the ?engineering approach? in economic science. It seems that the ?voice of
reason? has never been loud enough. This paper presents a review of the
above-mentioned problems.