bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRiYo : An observing system for deep repeated profiles of kinetic energy dissipation rates from shear-microstructure turbulence along a mooring line
Authors: Ferron B. , Leizour S. , Hamon M. , Peden O.
Published: December 2024

A new observing system that provides deep repeated profiles of the oceanic kinetic energy dissipation rate and small-scale mixing is presented. The system is designed to provide 300 dissipation rate profiles using a vehicle that cycles along a mooring line from the sub-surface down to a maximum depth of 4000 m. The system was tested for two weeks between 630 and 1700 m during a cruise that took place on the Lucky Strike segment of the Mid-Atlantic Ridge. The vehicle collected 35 profiles at a mean downcast velocity of 0.63 m s−1. To quantify the quality of the measurements, profiles from the mooring are compared with nearby profiles from an autonomous microstructure free-falling instrument. The dissipation rate noise level varies between O(10−10) and O(10−9) W kg−1. This noise level is low enough to detect turbulent patches at depth. The largest dissipation rate measured at this site was O(10−7) W kg−1.
Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons
Authors: Ye Fei , Deng Zhi-dan , Liu Kun-yu , Yao Xiu-mei , Zheng Wen-xiao , Yin Qiong , Hai Xiang , Gan Jian-kang , Zhang Zheng-Fen , Ma Zheng , Li Hua
Published: December 2024

Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To investigate the key metabolites affecting the quality of capons and the key regulatory mechanisms, Qingyuan partridge roosters were subjected to castration. Metabolic profiling was used to detect differential metabolites in the breast muscle of both capon and control groups. Additionally, an integrative analysis of transcriptomics and proteomics was conducted to explore the genetic regulation mechanisms influencing meat quality. The results indicated that the muscle fiber density and shear force of capons was lower than that of normal chickens, and the fat percentage of capon group (CAM) was higher than control group (COM). The expression of the metabolite inostine-5’-monophosphate (IMP) was lower in capons, and lipid metabolites (PC (10:0/10:0), PC (6:0/13:1), LPC 22:6, LPC 18:2, LPE 18:1, LPE 20:4) were higher in capons. Metabolic pathways were found to be a common signaling pathway in all omics. Glutamate-ammonia ligase (GLUL), acetyl-CoA carboxylase beta (ACACB), 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2), 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1) and glutathione S-transferase alpha 2 (GSTA2) regulate the expression of citric acid, arachidonic acid, palmitic acid, isocitric acid, and betaine. These findings highlight the key mechanisms contributing to the meat quality differences between capons and normal chickens.
Echinococcus granulosus sensu lato control measures: a specific focus on vaccines for both definitive and intermediate hosts
Authors: Borhani Mehdi , Fathi Saeid , Harandi Majid Fasihi , Casulli Adriano , Ding Jing , Liu Mingyuan , Zhang Wenbao , Wen Hao
Published: December 2024

Echinococcosis, a neglected zoonotic disease caused by Echinococcus tapeworms, presents significant public health challenges worldwide. Cystic and alveolar echinococcosis has substantial health and economic impacts, necessitating effective prevention and control strategies. The present review provides a framework to expand our knowledge regarding key components of echinococcosis prevention and control, including phases, options, targets and available tools as well as current gaps and challenges in the field. Furthermore, we discuss the progress made in developing vaccines for the intermediate and definitive hosts and review the limitations and obstacles in vaccine development for definitive hosts. Abundant information is available on various aspects of the Echinococcus vaccine in sheep. Livestock vaccination effectively reduces Echinococcus transmission to sheep, offering a feasible control measure in intermediate hosts. However, vaccine development for the definitive host, i.e. dogs, exhibits significant challenges. Information gaps regarding the immune-mediated protective responses in dogs, repeatability of results, factors influencing the immune response, reinfection resistance, potential age-related decreases in worm burden and factors associated with the antifecundity effect are key challenges that should be addressed in canine vaccine development, and research collaboration, innovative technologies, and a deeper understanding of transmission dynamics are crucial. Multisectoral coordination under the One Health framework, with long-term political commitment and national and international cooperation, is critical for effective control in endemic areas.

Graphical abstract
Treatment initiation and completion among head and neck squamous cell carcinoma patients in Tanzania
Authors: Xu Mary Jue , Haddadi Sumaiya , Mushi Beatrice Paul , Zhang Li , Sama Godfrey , Nyagabona Sarah Kutika , Ng Dianna , Muya Sikudhani , Malango Atuganile Edward , Richard Enica , Ha Patrick , Yom Sue S. , Massawe Willybroad , Mmbaga Elia J. , Van Loon Katherine , Nkya Aslam
Published: December 2024

Objective

Few studies characterizing clinical outcomes of head and neck cancer (HNC) patients in sub-Saharan Africa report the proportion of patients who initiate and complete treatment, information integral to contextualizing survival outcomes. This retrospective cohort study describes HNC patients who presented to Muhimbili National Hospital and Ocean Road Cancer Institute in 2018, the highest-volume oncology tertiary referral centers in Tanzania. Logistic regression was applied to assess predictors of treatment initiation and completion.

Results

Among the 176 head and neck squamous cell carcinoma (HNSCC) patients, 34% (59) had no treatment documented, 34%(59) had documentation of treatment initiation but not completion, and 33%(58) had documentation of treatment completion based on the modalities started. Univariate logistic regression showed that late-stage disease was associated with increased odds of initiating treatment (OR 8.24, 95% CI 2.05–33.11, p = 0.003) and trends toward completing treatment (OR 7.41, 95% CI 0.90–60.99, p = 0.063). At last visit, 36.9%(65) were alive with a median follow up of 5.6 months (IQR 1.64—12.5 months). A large proportion of HNC patients who presented to MNH and ORCI did not initiate or complete treatment. These metrics are critical to contextualize care outcomes of HNC patients in resource-constrained health systems and develop interventions.
The prevalence and clinical significance of EGFR mutations in non-small cell lung cancer patients in Egypt: a screening study
Authors: Helal Asmaa A. , Kamal Ibrahim H. , Osman Ahmed , Youssef Magdy , Ibrahim Adel K.
Published: December 2024

Background

Lung cancer is a form of cancer that is responsible for the largest incidence of deaths attributed to cancer worldwide. Non-small cell lung cancer (NSCLC) is the most prevalent of all the subtypes of the disease. Treatment with tyrosine kinase inhibitors (TKI) may help some people who have been diagnosed with non-small cell lung cancer. The presence of actionable mutations in the epidermal growth factor receptor (EGFR) gene is a key predictor of how a patient will respond to a TKI. Thus, the frequency of identification of mutations in EGFR gene in patients with NSCLC can facilitate personalized treatment.

Objective

The objective of this study was to screen for mutations in the EGFR gene and to investigate whether there is a correlation between the screened mutations and various clinical and pathological factors, such as gender, smoking history, and age, in tissue samples from patients with NSCLC.

Methods

The study comprised 333 NSCLC tissue samples from 230 males and 103 females with an average age of 50 years. Exons 18–21 of the EGFR gene have been examined using real-time PCR. Using SPSS, correlations between clinical and demographic variables were examined, and EGFR mutation and clinical features associations were studied.

Results

The study’s findings revealed that the incidence rate of EGFR mutation was 24.32% (81/333), with partial deletion of exon 19 (19-Del) and a point mutation of L858R in exon 21 accounting for 66.67% (P < 0.001) and 28.40% (P < 0.001) of the mutant cases, respectively. Patients who had the T790M mutation represent 4.94% (P = 0.004) of total number of patients. Females harbored EGFR mutations (54.32%) with higher frequency than men (45.68%) (P < 0.001), while nonsmokers had EGFR mutations (70.37%) more frequently than current smokers (29.63%) (P < 0.001).

Conclusion

The screening study conducted in Egypt reported that the EGFR mutations prevalence was 24.32% among Egyptians with NSCLC. The study also found a slight gender bias, with females having an incidence rate of these mutations higher than males. Additionally, nonsmokers had higher rates of mutations in EGFR gene compared to smokers. According to the findings, somatic EGFR mutations can be employed as a diagnostic tool for non-small cell lung cancer in Egypt, and they can be implemented in conjunction with clinical criteria to identify which patients are more likely to respond favorably to TKIs.
COVID-19 and liver
Authors: Sobh Rania S. , El-Shazly Sumaya H. , Zaky Samy , EL-Deen Nessren M. Bhaa , Hassany Mohamed , Kamal Lamiaa M.
Published: December 2024

Background and aims

The coronavirus disease 2019 (COVID-19) presents a significant health risk, affecting both healthy individuals and those with underlying health conditions, including liver diseases. This study aimed to evaluate the impact of COVID-19 on liver function in both hepatic and non-hepatic patients across varying degrees of disease severity, as confirmed by PCR testing.

Methods

In this prospective study, we included patients with confirmed COVID-19, both with and without liver conditions, who were admitted to the National Hepatology and Tropical Medicine Research Institute (NHTMRI) and Embaba Fever Hospital between November 2020 and July 2021.

Results

The study cohort consisted of 255 confirmed COVID-19 patients (mean age 52.16 years, 48.6% male, 24.3% with liver conditions). Among those with liver disease, 6.4% had mild symptoms, while 4.8%, 56.4%, and 33.8% experienced moderate, severe, and critical symptoms, respectively. Clinical characteristics were insignificantly different between hepatic and non-hepatic patients across the various COVID-19 severity grades, with the exception of the loss of taste and smell in severe cases and hepatic encephalopathy and oxygen saturation in critical cases. Laboratory findings similarly showed no significant differences, except that hepatic patients exhibited a notable decrease in platelet count and a significant increase in AST and bilirubin levels compared to non-hepatic patients. In critical COVID-19 cases, non-hepatic patients had significantly higher serum ferritin levels, while hepatic patients demonstrated increased serum bilirubin levels. Mortality was considerably higher in hepatic patients than in non-hepatic patients, particularly among those with severe and critical COVID-19. The study suggests that liver disease is associated with the progression to severe COVID-19, which includes a higher risk of mortality.

Conclusion

COVID-19 is linked to liver function impairment, with hepatic patients experiencing higher mortality rates compared to non-hepatic patients.

COVID-19, a novel coronavirus, presents a serious health threat to both healthy individuals and those with pre-existing health conditions. In this study, we evaluated its impact on individuals with liver disease compared to those without. The findings indicate that COVID-19 infection is associated with a decline in liver function and increased mortality rates in patients with liver disease.
Real-time three-dimensional transthoracic echocardiographic segmental volume analysis: a quantitative and objective tool for assessing regional left ventricle wall motion in patients with ischemic heart disease
Authors: Kwak Jin-Hwan , Choi Kang-Un , Park Jong-Il , Nam Jong-Ho , Lee Chan-Hee , Kim Ung , Park Jong-Seon , Son Jang-Won
Published: December 2024

Background

Evaluation of regional left ventricle function using two-dimensional echocardiography (2DE) in patients with ischemic heart disease has limitations due to its low objectivity and qualitative nature. In addition, 2DE is limited because multiple acoustic windows are used to obtain the image, whereas three-dimensional echocardiography (3DE) uses a single window. This study aims to demonstrate the clinical utility of 3DE segmental volume analysis for evaluating regional wall motion abnormality (RWMA).

Methods

This retrospective study included 33 patients with ischemic heart disease and single-vessel territory RWMA confirmed on coronary angiography. RWMA was visually assessed using 2DE, generating 17-segment bull's-eye polar maps, and 3DE. In the 3DE study, two independent observers analyzed segmental volumes and segmental volume ejection fractions (SVEFs) using QLAB 3D quantification software. The optimal SVEF cutoff value differentiating normal from abnormal was determined using receiver operating curve analysis. The accuracy of 3DE in predicting culprit coronary arteries was compared with that of 2DE using Cohen κ coefficients, which also were used for interobserver and intraobserver variability assessments.

Results

Mean 3DE SVEFs were significantly lower in segments showing RWMA on 2DE. The optimal SVEF cutoff value was 44%, with sensitivity of 75.0% and specificity of 73.9% (area under the curve, 0.801; 95% CI, 0.763–0.838; P < 0.001). The reliability of 3DE-derived bull's-eye predictions of culprit coronary arteries was 81.8% (κ = 0.672; 95% CI, 0.555–0.789; P < 0.001). Interobserver and intraobserver variabilities were 97.0% (κ = 0.947; 95% CI, 0.894–1.00; P < 0.001) and 93.9% (κ = 0.897; 95% CI, 0.827–0.967; P < 0.001), respectively.

Conclusions

The 3DE segmental volume analysis effectively quantified regional left ventricle function and aligned well with 2DE and coronary angiography findings in predicting culprit coronary arteries. Thus, 3DE segmental volume analysis can serve as a quantitative and objective tool for RWMA assessment in patients with ischemic heart disease.
Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset
Authors: Do Veena M. , Simpson Sierra , Fisch Kathleen M. , Gabriel Rodney A.
Published: December 2024

BACKGROUND:

This study examined the association between opioid-use disorder (OUD)-related diagnoses (eg, opioid dependence) and social determinants of health (SDoH) among patients with chronic pain.

METHODS:

A cross-sectional study was performed using the All of Us dataset (including >70,000 patients) to measure associations between SDoH and OUD using population- and individual-level surveys. Mixed-effects multivariable regression models (random effect being zip code) were conducted for each of the key SDoH domains. The odds ratio (OR) and 95% confidence interval (CI) were reported.

RESULTS:

There were 71,727 participants identified to have chronic pain, of which 7272 (10.1%) had OUD. Using data from all participants with population-level survey data available (n = 71,684), the Area Deprivation Index was associated with increased odds of OUD (OR, 5.70, 95% CI, 2.34–13.83, P < .001). Being unemployed (OR, 1.91, 95% CI, 1.59–2.31, P < .001) was associated with OUD. Chronic pain patients with a college degree or greater had lower odds of having OUD (OR, 0.48, 95% CI, 0.39–0.59, P < .001). Responses to questions related to delayed medical care (OR, 1.42, 95% CI, 1.20–1.69, P < .001) and inability to afford medical care (OR, 1.37, 95% CI, 1.16–1.63, P < .001) were associated with an increased odds of OUD. Chronic pain patients who were never married or without a partner (OR, 1.49, 95% CI, 1.28–1.73, P < .001) had higher odds of OUD.

CONCLUSIONS:

The study revealed a significantly greater social disadvantage metric in chronic pain individuals with OUD.
Human Resource Management Based on Sharia: How Employees Determine Sharia Law in the Context of Islamic Finance (Case Study: Bank Syariah Indonesia in Malang City, East Java)
Authors:   Department of Management Universitas Gajayana Malang, Malang, Ragil Bambang , Purnomo Eko Priyo , Hadiyati Ernani
Published: December 2024

Abstract. This research explores employee perceptions of Sharia principles in the context of Human Resource Management (HRM) at Bank Syariah Indonesia in Malang City, East Java. The study employs a case study design with a qualitative approach, chosen for its ability to provide an in-depth understanding of how employees perceive and apply Sharia principles within the framework of Sharia-oriented HRM at the bank. Data were collected through in-depth interviews, direct observation, and document analysis involving a purposive sample of 15 employees from various positions within the bank, including staff and managers, with diverse lengths of service and demographic characteristics. The findings suggest that education and training focused on Sharia principles are crucial in shaping employees' understanding and attitudes. Additionally, a Shariah-oriented organizational culture positively influences employee behaviors and attitudes, aligning them more closely with the institution's values. These results offer practical implications for Islamic financial institutions, emphasizing the need to strengthen educational programs and enhance organizational culture to foster Sharia-compliant human resources. Furthermore, the study highlights opportunities for better employee development, particularly in developing technical skills and integrating Islamic ethical values. In conclusion, this research significantly contributes to the literature on Islamic-oriented HRM and provides valuable insights for practitioners and researchers in the field.

Keywords: Human Resource Management (HRM), sharia principles, employee perception, islamic finance
The Influence of Transformational Leadership on Construction Services Business Performance Through TQM and Digital Capabilities in the Post-Covid-19 Era
Authors:   Fakultas Ekonomi dan Bisnis, Universitas Pancasila, Jakarta, Permana Erwin , Thalib Supriadi , Rachbini Widarto , Wulandjani Harimurti , Murni Yetty , Juliana Juliana ,   Fakultas Pendidikan Ekonomi dan Bisnis, Universitas Pendidikan Indonesia, Bandung
Published: December 2024

Abstract. The construction industry is one of the many global businesses that have felt the serious impact during the COVID-19 pandemic. Research on the construction services industry in the post-covid-19 era aims to: 1). Analyzing the influence of transformational leadership on company performance. 2) Analyze the influence of transformational leadership on digital capabilities. 3) Analyze the influence of transformational leadership on TQM. 4) Analyzing the influence of digital capabilities on performance, and 5) Analyzing the influence of TQM on performance. This study uses a quantitative approach. The research respondents were 100 leaders of construction service companies in Jakarta, the capital city of Indonesia. Data was collected through a questionnaire instrument. Data analysis was carried out using Structual Equation Model (SEM) With Partial Least Square (PLS). This research was carried out with a series of test scenarios, namely 1). digital capability as a mediator variable without TQM; 2). TQM as a mediator variable without digital capabilities; and 3). Digital capabilities together with TQM become a mediator between transformational leadership and performance. The research results show that without implementing TQM, digital capabilities mediate the relationship between transformational performance. Without digital capabilities, TQM completely mediates the influence of transformational leadership on performance. If digital capabilities and TQM are used as mediation simultaneously, TQM becomes a complete mediating variable in the relationship between transformational leadership and the performance of construction service companies in the post-Covid-19 era. This research opens up opportunities and recommends the emergence of research that integrates TQM-Digital.

Keywords: Transformational leadership, digital capabilities, TQM and Performance
Innovation Platforms as A Strategy to Support the Agricultural Innovation System in Indonesia: Case study on The Implementation of Jajar Legowo Super
Authors:   National Research and Innovation Agency Republic of Indonesia (BRIN), Purwaningsih Indah , Ayunda Winda Anestya , Ariana Lutfah
Published: December 2024

Abstract. The strategy for utilizing research results through collaboration between stakeholders is crucial in developing agricultural innovation system. This study examines the multi-stakeholders collaboration on the scaling process of the Jajar Legowo (Jarwo) Super technological package as the research result of the Agricultural Research and Development Agency (Balitbangtan), Ministry of Agriculture (MoA), Indonesia. Employing the innovation platform framework, this study explores the multi-stakeholders’ perspectives by conducting semi-structured interview with related stakeholders: researchers, policy makers, disseminators, and local governments. The innovation platform framework is applied to map the actors, roles and functions that support the scaling process along the value chain from the problem identification, towards technology development through experimentation and the upscaling process in the system. The study finds that the innovation platform succesfully improve the rice productivity in some regions despite some challenges. Instead of full technology application, farmers prefer integratge them with indigenous practice due to the limited absorptive capacity, socio-economic background and natural conditions of the region. Also, the findings highlight the gap in multistakeholder relation despite the central rolef of the central government that not only act as a policy maker but also technlogy developer, disseminator, and logistic providers. The goverment is suggested to enhance the institutional arrangements by engaging industry in input logistic system to provide farmers’ access on technology supply and integrate policoes/programs with the local government and other related stakeholders to accelerate the upscaling process.

Keywords: Agricultural innovation system; Innovation platform; Jajar legowo super; Multi-stakeholders collaboration, sclaing process
SYSTEMATIC ANALYSIS OF THE WASTEWATER TREATMENT PROCESS OF LIVESTOCK FARMS
Authors: Savdur Svetlana , Voroncova Valeriya
Published: December 2024

System analysis of the wastewater treatment process of livestock farms is an important stage in ensuring environmental safety and sustainable development of animal husbandry. The main objective of the work is to improve the efficiency of the wastewater treatment process of livestock farms based on system analysis. Wastewater generated on farms contains a high level of organic pollutants, pathogenic microorganisms and nutrients, which can significantly affect the quality of the environment. To solve this problem, an integrated approach was used, which included hydrological, biochemical and technological aspects. The possibility of introducing modern biotechnology is considered, which will significantly reduce the negative impact on the environment and increase the level of sustainability of livestock enterprises. Depending on the sources of pollution and the main pollutants, technical solutions were developed to reduce the volume of wastewater and purify it. The efficiency of their operation can be ensured with the help of modern methods of information processing, using methods of system analysis of complex objects based on a mathematical description of the technological process. A two-level system model was developed to study the patterns of operation of a bio-treatment device under conditions of dynamically changing parameters of the technological process. To analyze the state of the treatment system as a whole and predict the development of emergency situations, a software implementation of a wastewater treatment system for livestock farms was created.
The Impact of Physical Activity on Neuroprotection in Neurodegenerative Diseases: A Special Focus on Parkinson’s Disease
Authors: Buczek Aleksandra , Jakubczyk Paulina , Bilczewska Olga , Janik Wiktoria , Handschuh Marta , Helis Justyna , Widera Piotr , Banaś Aleksandra , Michalik Maciej , Bigajski Hubert
Published: December 2024

Aim of the studyThis study examines the impact of physical activity on neuroprotection in neurodegenerative diseases, focusing on Parkinson’s Disease (PD). It evaluates neuroprotective mechanisms, analyzes physical activity’s role in PD progression, assesses various exercise forms’ effectiveness on PD symptoms, and identifies research challenges and future directions.
Materials and methodsA comprehensive literature search was conducted across major databases, prioritizing studies from the past 15 years, particularly longitudinal studies and randomized controlled trials. The review critically evaluated neuroprotective mechanisms, exercise specificity, and effects on PD symptoms.
State of knowledgeRegular physical activity enhances neuroplasticity, regulates neurotrophic factors, reduces oxidative stress, and mitigates inflammation in PD patients. Various exercise forms show effectiveness in managing PD symptoms and potentially slowing disease progression. Challenges remain in optimizing interventions for individual patients and integrating physical activity into comprehensive PD management strategies.
ConclusionsThe review highlights physical activity’s significant neuroprotective effects in PD, demonstrating its potential to manage symptoms and slow progression. Research gaps persist regarding long-term effects and personalized interventions. Future research should focus on optimizing exercise protocols, investigating synergistic effects with pharmacological treatments, and developing personalized interventions. This review supports physical activity as a valuable adjunctive therapy in PD, potentially influencing treatment paradigms in neurodegenerative disorders.
Evaluation of the Efficacy of Laser Therapy in Treating Postoperative Scars in Athletes and Its Impact on Recovery Time and Return to Physical Activity
Authors: Leicht Jakub , Kossakowska Aleksandra , Hassan Aisha , Hassan Sara , Bienia Szymon , Al-Batool Wafa , Konieczna Klaudia , Zarecka Izabela
Published: December 2024

Postoperative scarring presents a significant challenge in sports medicine, particularly for athletes seeking a rapid return to intensive physical activity. This study aimed to evaluate the efficacy of laser therapy in improving the quality of postoperative scars and its impact on rehabilitation time. A cohort of competitive athletes aged 18–40 with hypertrophic scars resulting from orthopedic surgeries underwent five biweekly sessions of laser therapy using fractional CO2 and pulsed dye lasers (PDL). Scar assessment included the Vancouver Scar Scale (VSS) and Cutometer-based skin elasticity measurements, with additional evaluations of pain and functionality using the Visual Analog Scale (VAS). Fractional CO2 laser therapy significantly reduced VSS scores by 2.5 points and increased skin elasticity by 15%, while PDL therapy effectively decreased erythema by 30%. Athletes treated with laser therapy returned to high-intensity training an average of three weeks earlier than those receiving standard scar treatments. Side effects, such as transient redness and swelling, were mild and resolved within 2–3 days. These findings suggest that laser therapy, particularly fractional CO2 and PDL, is a safe and effective intervention for managing postoperative scars in athletes, enhancing both aesthetic and functional outcomes while accelerating rehabilitation timelines. Further research is recommended to optimize protocols and evaluate long-term benefits.
The Impact of Physical Activity on Skin Health and Condition: Physiological Mechanisms and Dermatological Effects
Authors: Dolata Natalia , Balcer Bartosz , Liszka Paweł , Pakuła Mateusz , Weimann Maja , Kruczkowska Adrianna , Stosiek Aleksandra , Cebula Agnieszka , Bulzacki Emil , Urbański Wojciech
Published: December 2024

Introduction and purpose: 
The skin, the largest organ of the human body, plays a crucial role as a protective barrier. Its condition deteriorates with age and under the influence of external factors such as UV radiation, stress, or diet. This review examines the impact of physical activity on skin health, focusing on mechanisms that enhance its function and appearance. 
Materials and Methods 
A literature review was conducted using medical databases, including PubMed and Google Scholar. Articles were retrieved in English using keywords such as “physical activity,” “skin health,” “effects of exercise on skin,” “anti-aging effects of physical activity,” and “antioxidant properties of exercise” in various configurations. 
Description of the state of knowledge: 
Regular physical activity positively affects skin health by improving microcirculation, stimulating collagen synthesis, hydrating the stratum corneum, and reducing oxidative stress and inflammation. Exercise also supports the skin barrier function and may alleviate the course of dermatological conditions such as psoriasis or atopic dermatitis. Additionally, physical activity improves sleep quality and mental well-being, which indirectly benefits skin health. The potential of facial exercises to enhance aesthetics is also noted, though their effectiveness requires further research. Despite numerous benefits, some forms of activity, such as swimming, may negatively affect the skin barrier due to exposure to irritating chemical substances. 
Conclusion: 
In summary, physical activity has a multidimensional impact on skin health, supporting its protective functions, appearance, and anti-aging properties. However, further research is needed to better understand the mechanisms and efficacy of specific types of exercise.
De schismate Robertino. Nieznany traktat Ludolfa z Żagania o początkach Wielkiej Schizmy Zachodniej
Authors: Mrozowicz Wojciech
Published: December 2024

Prezentowane opracowanie zawiera omówienie i wydanie nieznanego traktatu O schizmie robertyńskiej (De schismate Robertino) z 1404 r., pióra wybitnego koncyliarysty Ludolfa, opata klasztoru kanoników regularnych św. Augustyna w Żaganiu. Tytuł traktatu nawiązuje do imienia Roberta z Genewy, którego wybór na papieża (Klemensa VII) w 1378 r. stał się początkiem Wielkiej Schizmy w Kościele. Ludolf poszukuje w traktacie sposobu na przezwyciężenie Schizmy. Z odwołaniem do argumentacji opartej na Biblii i przepisach prawa wykazuje w pełnym retorycznego zaangażowania wywodzie błędy zwolenników papieży awiniońskich i usiłuje ich przekonywać do przejścia na stronę rzymską.
AI LIMITI DEL DISCORSO U-TOPOS, O L’ASSENZA DI LUOGO
Authors: Broullon Lozano Manuel A.
Published: December 2024

Il contributo verte sulla lettura del discorso utopico offerta da Louis Marin, che a partire
dall’analisi del romanzo di Thomas More individua una tipologia discorsiva caratteristica della
modernità. Obiettivo principale del lavoro è mettere in luce le potenzialità euristiche del modello
tracciato da Marin nello studio dei rapporti fra potere, spazio e soggettività, laddove i discorsi e le
pratiche utopiche passati e contemporanei possono costituire un terreno privilegiato d’osservazione
di dinamiche culturali più generali
LA UTOPÍA ANTROPOLÓGICA DEL NUEVO REINO DE SAN FRANCISCO: FRAY MARCOS DE NIZA Y SU SUEÑO AMERICANO
Authors: Urani Montiel Contreras Carlos , FranCo de la o María Yatzil
Published: December 2024

La topografía y cartografía del septentrión novohispano sedujeron a exploradores,
navegantes y evangelizadores dispuestos a hallar su bagaje y propensiones en un terreno
desconocido, en el actual norte de México. Fray Marcos de Niza sobresale de entre sus coetáneos, ya
que su expedición recoge mitos y leyendas de ciudades maravillosas sobre las que la administración
virreinal requería certifcaciones y juramentos. La experiencia del franciscano en ambos polos
continentales y, sobre todo, su formación religiosa de raigambre medieval sustentan un viaje que
vislumbró, paradójicamente, las ultimidades de la historia en el Nuevo Mundo. Su “Relación”,
muchas veces leída como un falso testimonio, guarda entre líneas un correlato místico cifrado en
el Apocalipsis. Fray Marcos entrevió un Nuevo Reino de San Francisco poblado por tribus que
parecían coincidir con las profecías de san Juan. Esta voluntad reduccionista devino en una utopía
propicia para la diplomacia entre naciones y la conversión al catolicismo. El sueño americano del
misionero debe enmarcarse bajo la ilusión de una metrópoli que vaticinaba la parusía de Cristo en
la antesala de un nuevo milenio
CAMBOYA AÑO CERO: LA RECONSTRUCCIÓN DE LA ANTIUTOPÍA DE LOS JEMERES ROJOS EN LA IMAGEN PERDIDA (2013) DE RITHY PANH
Authors: MARTÍN SANZ ÁLVARO
Published: December 2024

El presente artículo busca deconstruir la representación que Rithy Panh realiza del
periodo de la Kampuchea Democrática en su celebrada obra de no fcción La imagen perdida (2013).
Así pues, se plantea si es posible la creación desde cero y sin prácticamente material de archivo
de una imagen global que sea fel a la historia acontecida de una determinada época en contra de
toda una serie de documentos audiovisuales que forman parte de un aparato de propaganda de corte
utópico, en este caso promovido por un régimen totalitario como fue el de los Jemeres Rojos.
El sesgo de género en las imágenes de los libros de texto de inglés de Educación Secundaria
Authors: Barros-del Rio Maria Amor , Rojo-Pajares Teresa , Rojo-Pajares Teresa
Published: December 2024

El objetivo de este trabajo es establecer en qué medida existe un sesgo de género en los
materiales docentes utilizados para la enseñanza del inglés en la Educación Secundaria Obligatoria a
través de las imágenes reales contenidas en los libros de dos prestigiosas editoriales. A partir de unos
indicadores determinados, se realiza un estudio estadístico descriptivo que proporciona información
cuantitativa sobre los estereotipos y modelos presentados al alumnado. Esta información se completa
con un análisis cualitativo basado en una adaptación del modelo propuesto por Cunningsworth
(1995). A la luz de los datos obtenidos, se realiza un estudio comparativo para determinar el sesgo
de género en los libros de texto y establecer qué áreas precisarían una intervención.
De la locura del verso: aproximación a la figura y la obra de Remedios Picó Maestre.
Authors: Cacciola Anna
Published: December 2024

Entre las protagonistas de la lírica valenciana de la pasada centuria, Remedios Picó
Maestre (Monóvar, 1885-1969) se considera la poeta más prolífca de la modernidad literaria
alicantina. Su verso intimista, de abolengo postromántico y modernista, entraña un discurso lírico
propiamente femenino y en perfecta consonancia con el espíritu de la Edad de Plata. El presente
artículo pretende ofrecer una aproximación a la fgura y la obra de la monovera que permita, por un
lado, remontarnos a las claves estilístico-textuales de su poética, relacionada con la emancipación
social y política de las mujeres, durante el primer tercio del siglo XX; por otro, revelar la sensibilidad
humana y artística de una poeta injustamente denostada, para quien la conjunción de vida y escritura
se hace imprescindible para esclarecer la complejidad de su personalidad.
«El placer de lo inesperado»: poemas inéditos de Victorina Durán.
Authors: Moreno Lago Eva María
Published: December 2024

En el siguiente estudio se presenta por primera vez una colección de poemas inéditos de
Victorina Durán encontrados en el archivo del Museo Nacional del Teatro de Almagro. El análisis
se centrará en las diversas reacciones que el deseo lésbico provoca en las protagonistas de sus
versos: desde el mutismo hasta la angustia por lo desconocido, el miedo por el rechazo social y
el inevitable placer que le ofrece la amada. El juego de contrarios entre el dolor y el vitalismo
será fundamental para entender la esencia de las experiencias amorosas de Durán. Se pretende
visibilizar unas relaciones afectivas que han pasado inadvertidas e incrementar los estudios sáfcos
en la Literatura Española
Notas sobre la evolución de las ideas de destierro y de España en las cartas de Pedro Salinas: materialización del sentimiento exilar.
Authors: Ramírez Riaño Adrián
Published: December 2024

El estudio de los epistolarios de los escritores del siglo XX se ha convertido en algo cada
vez más usual como escrito literario autobiográfco y fuente primaria histórica. Uno de los escritores
más importantes del género en España es Pedro Salinas, quien, durante su exilio norteamericano,
recurrió a las cartas como escritura indispensable en su concepción literaria. En este trabajo se
realiza un análisis de la confguración del concepto de exilio en las misivas de Pedro Salinas. Para
ello se considerará temáticamente el desarrollo textual del sentimiento sobre el exilio, junto con las
consideraciones que hace el poeta de la situación de España, que transmutan de la esperanza en la
victoria republicana a la resignación del exilado que conoce la incapacidad de volver a su patria.
El Almanach de Gotha - producción, distribución y circulación de un almanaque en francés en Europa a finales del siglo XVIII y las primeras décadas del siglo XIX.
Authors: Lüsebrink Hans-Jürgen
Published: December 2024

The Almanach de Gotha, published in French in Gotha in Germany between 1764 and 1944 first
by the publisher Dieterich and then by the publishers Ettinger and Perthes for almost two centuries, was
the reference genealogical almanac for the European aristocracy of the 18th century, the 19th century and
first half of the 20th century. The almanac published not only detailed genealogical information, but also
a calendar, literary anecdotes and extracts from novels, and multiple information on fashion, literary and
theatrical novelties, scientific innovations as well as significant historical events.
Starting from theoretical and methodological reflections, this contribution aims to first highlight the process
of manufacturing this almanac, and then its distribution and reception among a fundamentally elitist and
transnational public. The case of the censorship of the almanac in 1808 by Napoléon Bonaparte who was very
sensitive to the aristocratic and royal genealogies published in the Almanach de Gotha, is also analyzed, certain
orientations of which could fundamentally call into question Napoléon’s legitimacy and that of the princes that
it he had placed on European thrones, in particular members of his own family. This contribution is linked to a
research project, carried out in cooperation with York-Gothart Mix (München), on French-speaking almanacs in
the German cultural and linguistic area between 1700-1815. Based on detailed bibliographic research, partly in archives, it essentially concerns the first period of publication of this almanac, that is to say the years 1764 to 1830
De la religiosidad de la naturaleza al espiritismo socialista: sinergias anglo-hispanas, Felicia Hemans y las autoras de la prensa sevillana del XIX.
Authors: Benítez Alonso Elena María
Published: December 2024

N Desde un moderado concepto liberal de religiosidad de la naturaleza hasta el radicalismo
rupturista con la ortodoxia católica de un espiritismo entrelazado con el socialismo utópico, la colaboración
autorial femenina en la prensa sevillana decimonónica defendió la tolerancia religiosa frente a su encorsetada
sociedad. Aunque tradicionalmente se ha destacado su identificación con convencionalismos coetáneos, el
estudio detallado de cabeceras de la época revela la importancia del posicionamiento rupturista, posibilitando
la relectura del papel autorial femenino a partir del grupo liderado por la sevillana Amalia Domingo Soler y
que pudo imbuirse de la reinterpretación espiritista, tras la recepción en la prensa española, de la obra de
contemporáneas inglesas como Felicia Hemans, la más leída en el mundo angloparlante de su tiempo y a su
vez influida por la heterodoxia del también sevillano Blanco White, ante las sinergias generadas por el éxodo
liberal español al Londres de inicios del XIX
El Socialista: notas para el estudio del periodismo español en el exilio.
Authors: Ruiz Acosta María José
Published: December 2024

Con el término de “prensa alófona” o “transfronteriza” se hace referencia a un medio de
comunicación que se redacta en una lengua distinta a la del país en el que se edita. Fruto de emigraciones
forzosas o de desplazamientos de población, tal fenómeno toma carta de naturaleza en Europa al menos
desde el siglo XVIII.
En nuestro trabajo estudiamos una cabecera representativa de la prensa transfronteriza española. Se trata
de El Socialista, periódico creado por Pablo Iglesias en 1886 y que, como consecuencia del exilio de sus
promotores, se editó en el extranjero durante más de tres décadas. El interés de esta radica principalmente
en reconocer la función que tuvo a la hora de preservar y de difundir una ideología que fue prohibida en
España al término de la Guerra Civil.
Aunque su trayectoria no estuvo exenta de problemas y vicisitudes, El Socialista consiguió superarlos y volver
a publicarse en España tras el restablecimiento de la democracia y, por ende, de la libertad de expresión y
de información.
Guedesburgo. Lourenço Marques e lo Stiloguedes
Authors: Giani Esther
Published: December 2024

Il contributo verterà sulla dimensione urbana dell’opera di Amancio d’Alpoim Miranda Guedes (1925-2015), noto anche come Pancho Guedes, nella mozambicana Lourenço Marques pre-indipendenza (1950-1975). Argomentando la natura duale della città di fondazione e la netta demarcazione tra gli insediamenti informali e la città coloniale tramite una viabilità semi-anulare, si porta all’attenzione la presenza di un tracciato cartesiano che ha permesso invenzioni “anarchiche”. Nonostante la breve storia e una crescita diseguale della città, si registra una stratificazione e una ricchezza di linguaggi inedita per le città africane di matrice coloniale. In tale effervescenza linguistica si posiziona Guedesburgo: l’opera di Pancho Guedes (circa 500 architetture realizzate) che nel tumulto del dettaglio pone un diverso ordine all’insieme.
L’“altra modernità” di Demas Nwoko. Un’alternativa forma di pensiero climatico
Authors: Vaccher Flavia
Published: December 2024

Un approccio innovativo, una sorta di sintesi tra i principi della Tropical Architecture e gli elementi della tradizione locale, è quello intrapreso dall’architetto-artista Demas Nwoko, che formalizza dapprima nel manifesto Natural Syntesis e poi nella rivista New Culture: A Review of African Arts. Esso è frutto di un’espressione poetica personale caratterizzata da un alto grado di sperimentazione, sulla quale il periodo trascorso presso l’École des Beaux-Arts, i viaggi in Europa e negli Stati Uniti hanno avuto certamente un peso determinante. Un’esperienza progettuale poco conosciuta ma consolidata, indissolubilmente legata al clima, al luogo e ai materiali; una modernità “altra” ma non necessariamente vernacolare, che rispecchia il cosmopolitismo della Nigeria degli anni post coloniali.
Il Moderno brasiliano di Crofton e Benjamin in Sudafrica, Las Vegas e la creazione di uno “stile”
Authors: Bodei Silvia
Published: December 2024

L’edificio Las Vegas (1956-57), un volume a forma curva di dieci piani più attico sormontati da una grande pensilina che ospita trentadue unità abitative di lusso, si trova sul lungomare della città portuale di Durban (Sudafrica). Progettato dagli architetti sudafricani Derek Crofton e Issy Benjamin, esprime un tipo di architettura residenziale collettiva vicina alle forme in calcestruzzo del Moderno brasiliano, ma con tratti specifici e locali. La facciata e la struttura ad articolazione tripartita in sezione, che si adattano al clima e al paesaggio sub-tropicale circostante, costituiscono in particolare un prototipo di residenze dove, come spiega lo stesso Benjamin, «il nostro stile si sviluppò concretamente». Negli anni successivi (1957-1964) i due architetti costruiranno infatti in città altri complessi residenziali che, pur con le loro peculiarità, sono uniti da un’idea architettonica e stilistica comune e tra le più interessanti del Moderno sudafricano del periodo.
Tropical modernism in Léopoldville ans decolonization. Case study of Lovanium by Marcel Boulengier
Authors: Tshiunza Alexis , Ockerman André , Nkondi Jonathan
Published: December 2024

In 1949, the Belgian Congo benefited from a major development program called the ten-year plan. But the policy of segregation is strongly encouraged. Nevertheless, in 1950, architect Marcel Boulengier (1909-1976) is asked to draw a general plan for the construction of an interracial University. After careful examination of the plan, several detailed adjustments were made in order to avoid any segregation. Many Belgians rightly thought that this project would accelerate independence. The article examines how the architecture and urban planning proposed for this project built on an uninhabited site reflects decolonization and even indigenization.
Esperienze di realismo e architettura nell’Africa Subsahariana. Insediamenti urbani, servizi per la salute, infrastrutture per la ricerca in Sudan, Etiopia, Tanzania (2005-23)
Authors: Del Monaco Anna Irene
Published: December 2024

Il testo raccoglierà alcune esperienze progettuali elaborate per organizzazioni di ricerca e internazionali negli ultimi vent'anni in Sudan, Etiopia e Mozambico, elaborate per quartieri da riprogettare e per piccoli edifici destinati servizi pubblici che tengono conto di aspetti che riguardano la realtà climatica tropicale e più in generale gli aspetti di contesto dell'africa sub-sahariana. Il racconto si relazionerà con le preesistenze realizzate nelle rispettive realtà urbane durante il Novecento da architetti locali ed europei contribuendo a costruire una idea di architettura moderna più o meno consolidate. Alcuni disegni di progetto sono inediti
The emergence and development of shockwave intravascular lithotripsy
Authors: Palmer Sarah Jane
Published: December 2024

In this issue's Tech Pages feature, Sarah Jane Palmer provides an overview of research developments in the intravascular use of shockwave lithotripsy for patients with cardiovascular conditions.
Traumatic brain injury in sport
Authors: B Momin Sheikh M , Belli Antonio , O'Halloran Philip J
Published: December 2024

Sports-related concussion (SRC) is a subset of mild traumatic brain injury (mTBI) occurring following an impulsive force transmitted to the brain during sporting activity. There is increased public recognition of the long-term consequences following SRC, particularly repetitive events. SRC remains a clinical diagnosis, although active research is ongoing in identifying objective tests to aid diagnosis and aid prognosis of persistent post-concussive symptoms. This editorial aims to summarise the state of the art of SRC assessment and management, reviewing literature evidence of contemporary pitchside and office clinical assessments, while highlighting return-to-play guidelines in several major sports. Additionally, ongoing research on objective biomarkers of SRC are highlighted, including fluid-based and imaging biomarkers.