bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Modeling Studies of Natural Inhibitors of Androgen Signaling in Prostate Cancer
Authors: Olubode Samuel O , Bankole Mutolib O , Akinnusi Precious A , Adanlawo Olayinka S , Ojubola Kehinde I , Nwankwo Daniel O , Edjebah Onome E , Adebesin Ayomide O , Ayodele Abigail O
Published: August 2022

Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention. As an androgen-dependent illness that relies on the androgen receptor for development and progression, inhibition of the androgen receptor can lead to a therapeutic solution, hence serving as a vital therapeutic target. This study focused on the computational analysis of the inhibitory potentials of Vitis vinifera, a reported plant with anti-cancer properties, against androgen receptor employing molecular docking, ADMET studies, Binding energy study, pharmacophore modeling, and molecular dynamics simulation approaches. After the investigation, it was determined that 5 compounds: cis-piceid, cis-astrigin, gallocatechin, phlorizin, and trans-polydatin, might be possible androgen receptor inhibitors since they had higher docking scores and ADMET qualities than compared standards, with cis-piceid being the best-predicted inhibitor.
Clinical Outcomes Following Simple or Complex Stenting for Coronary Bifurcation Lesions: A Meta-Analysis
Authors: Zhang Qun , Huan Hengshan , Han Yu , Liu Han , Sun Shukun , Wang Bailu , Wei Shujian
Published: August 2022

Background:

Stent placement remains a challenge for coronary bifurcation lesions. While both simple and complex stenting strategies are available, it is unclear which one results in better clinical outcomes. This meta-analysis aims to explore the long-term prognosis following treatment with the 2 stenting strategies.

Method:

Randomized controlled trials found from searches of the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were included in this meta-analysis. The complex stent placement strategy was identified as the control group, and the simple stent placement strategy was identified as the experimental group. Data were synthesized with a random effects model. The quality of the randomized controlled trials was assessed by Jadad scale scores. The clinical endpoints at 6 months, 1 year, and 5 years were analyzed.

Results:

A total of 11 randomized controlled trials met the inclusion criteria. A total of 2494 patients were included in this meta-analysis. The odds ratio [OR] of the major adverse cardiac events (MACEs) at 6 months was 0.85 (95% confidence interval [CI] 0.53-1.35; P = .49, I2 = 0%). The OR of the MACEs at 1 year was 0.61 (95% CI 0.36-1.05; P = .08, I2 = 0%). The OR of the MACEs at 5 years was 0.69 (95% CI 0.51-0.92; P = .01, I2 = 0%). Compared with the complex strategy, the simple strategy was associated with a lower incidence of MACEs at 5 years.

Conclusion:

Compared to the complex stenting strategy, the simple stenting strategy can better reduce the occurrence of long-term MACEs for coronary bifurcation lesions.
Osteochondroma of the Tibial Tubercle Masquerading as Osgood-Shlatter Disease: A Case Report
Authors: Agaronnik Nicole D , Landrum Matthew , Wait Trevor , Hogue Grant D
Published: August 2022

Background:

Osteochondromas are a relatively common primary bone tumor, which may share common clinical features with Osgood-Schlatter disease (OSD). A limited number of cases have described tumors misdiagnosed as OSD.

Case Presentation:

We report the case of an 11-year-old male with a sessile osteochondroma of the tibial tubercle and concomitant involvement of the distal extension and attachment of the patellar tendon into the tibial periosteum. A prior diagnosis OSD had been made. The lesion was resected and repair of the extensor mechanism was required at the time of surgery. The patient was followed for 20 months postoperatively and had restoration of knee function with minimal pain, as demonstrated by a PEDI-IKDC score of 94.6 at 19-month.

Conclusion:

This is a rarely reported case of benign tumor masquerading as OSD requiring excisional biopsy with extensor mechanism repair.
An experimental study on mechanical behavior of nylon fabric laminated rubber bearings
Authors: Zhang Yan , Wu Yi-feng , Li Ai-qun , Xu Hong
Published: August 2022

Five samples of the nylon fabric laminated rubber bearing were manufactured with different rubber layer thickness and nylon cloth specifications. The compression and compression shear tests were conducted to evaluate the mechanical properties of the bearings. Results show the novel bearings’ vertical stiffness is significantly lower than that of laminated steel rubber bearings, but their vertical damping ratio can reach 7%. The effective horizontal stiffness decreases with increasing shear strain due to rollover deformation. The bearings do not get seriously damaged when the shear strain is 300%. The equivalent damping ratio of the bearings varies in the range of 9%–13%.
Acoustic field characteristic analysis of the rotary acoustic cavity coupled system
Authors: Chen Tianlin , Zhang Hong , Huang Bo
Published: August 2022

The rotary acoustic cavity coupled system can be generated in working conditions of aviation, aerospace, ship, machinery, and other fields. The rotary acoustic cavity includes cylindrical, spherical, and conical acoustic cavities, which integrates into the unified analysis model by iso-parametric transformation in finite element method. To study the acoustic field characteristic of rotary acoustic cavity coupled system, a unified analysis model of rotary acoustic cavity coupled system is established: First, the acoustic field characteristic of the coupled system is researched by improved Fourier series method, and the admissible sound pressure function is constructed by three-dimensional modified Fourier series. Then, the acoustic field domain energy functional is established, and the coupled domain energy functional including the coupled potential energy between the sound cavities is introduced to acquire the total energy functional of the coupled system. Finally, the energy equation is solved by Rayleigh–Ritz method, and the natural frequency and corresponding mode of the coupled system are obtained. The unified analysis model demonstrates excellent convergence and accuracy, which is verified by the results of finite element method. Sound pressure responses of the coupled system are obtained by introducing the internal point sound source excitation. The effect of relevant parameters of the coupled system on natural frequency and sound pressure response is investigated, which can provide theoretical guidance for vibration and noise reduction.
Computational investigation of ammonia-hydrogen peroxide blends in HCCI engine mode
Authors: Shafiq Omar , Tingas Efstathios-Al.
Published: August 2022

The potential use of hydrogen peroxide as an ignition promoter to enable the use of ammonia in compression ignition engines is explored in the current study. A simplified numerical HCCI engine model within the Chemkin Pro suite is employed. The numerical investigation reveals that the proposed use of hydrogen peroxide is significantly more advantageous against the more conventional method of preheating the intake charge to achieve ignition, whilst using a glow plug. In particular, the IMEP, power and torque exhibit an increase greater than 65% along with a spectacular decrease of NOx emissions reaching in certain cases a 9-fold decrease. The thermal efficiency exhibits a more moderate, yet non-negligible increase, around 5%. Generally, the incremental increase of hydrogen peroxide leads to the increase of the IMEP, power and torque as well as the maximum temperature and, hence, NOx emissions. These increases are largely linear with the hydrogen peroxide addition. Finally, the introduction of hydrogen peroxide leads to a two-stage ignition process, where the first ignition stage was found to be instrumental to the control of the ignition process, and, therefore, the system’s efficiency. Further research is required to substantiate further the feasibility and the the limitations of the proposed technology which can enable the rapid decarbonization of heavy duty applications, such as marine ships and trucks.
Understanding the lived experiences of family caregivers of individuals with dementia in Soweto, a South African Township
Authors: Mahomed Aqeela , Pretorius Chrisma
Published: August 2022

This study was undertaken to understand South African family caregivers’ lived experiences of individuals living with dementia in a predominantly Black African township. A homogenous sample of thirty family caregivers was recruited using purposeful sampling methods and interviewed using a semi-structured approach. Reflective Thematic Analysis (RTA) yielded four broad themes: Understanding Dementia, Struggles and Sacrifice, Mental Health and Protective Factors. Findings reflect how dementia is understood by family caregivers and their community, the struggles and sacrifices that they endure, the impact of caregiving on caregiver mental health and the protective factors that enable caregivers to cope, despite their difficulties. Our findings lead to new insights regarding dementia caregiving amongst family caregivers in South Africa. First, there appears to be a shift in perception – away from a cultural/spiritual paradigm – and a lack of pressure to conform to community conceptualizations of dementia among individual caregivers. Second, dementia caregiving had a negative effect on caregiver mental health and elicited stress, anxiety and grief reactions. Third, caregivers did not feel emotionally supported and expressed not receiving any assistance with their daily practical tasks. Fourth, before receiving a diagnosis, family caregivers were viewed as the perpetrators of abuse and/or neglect against their family members with dementia, instead of individuals with dementia being stigmatized by the community due to their behavioural symptoms. Additionally, help-seeking was not hindered by fear or stigma, but was motivated by caregiver distress as dementia-related behaviours began to manifest and caregivers feared being perceived as perpetrators of abuse. Psychoeducational interventions should be tailored to targeted population groups that are in need of further training to address the lack of awareness in communities, insufficient knowledge of dementia amongst healthcare professionals and the practical, emotional and psychological difficulties that family caregivers endure to facilitate mental health care and resilience.
Thrombosis in Scotland, 1800–1960
Authors: Lowe Gordon
Published: August 2022

From 1800, arterial thrombosis and venous thrombosis were increasingly recognised as causes of sudden death. By 1960, they had replaced infections as the commonest cause of death in Scotland and the UK, as in many developed countries. The important contributions of Scotland’s doctors between 1800 and 1960 to the knowledge of thrombosis, and to its treatment and prevention by anticoagulant drugs, are reviewed.
An Inclusive Leadership Model Insights From the Tech Industry
Authors: Booker Dante L. , Williams Michael R.
Published: August 2022

Problem

Inclusive leadership models have been introduced to represent a shift from traditional leadership approaches. However, missing from these models are principles of social justice and forward-thinking outcomes for building human relations. An examination of the detrimental consequences of exclusion is needed to realize the benefits of inclusion.

Solution

The Deconstructing Exclusion for Inclusive Leadership model, a framework for practice, is offered as a practical guide for deconstructing exclusionary practices and building positive, healthy human relations. The model is supported by affective behaviors and traits and cognitive competencies that inclusive leaders need to discourage exclusion and advocate for more inclusive relationships and social justice outcomes.

Stakeholders

Leaders, managers, practitioners, human resource development scholars, researchers, and educators.
Domestic Violence Protection Orders for Teen Dating Violence: An Analysis of State Laws and Practices
Authors: Lee Jina , Kanaboshi Naoki , Petlakh Ksenia
Published: August 2022

Purpose:

The purpose of this research is to provide an overview of state laws on domestic violence protection orders (DVPO) for teen dating violence. DVPOs are one legal remedy that is available to victims of intimate partner violence to reduce the potential risk of future violence. However, minors are often prohibited from filing a DVPO on their own due to statutory requirements.

Method:

Using multiple resources and a Westlaw search, we developed a list of state laws pertaining to the statutory requirements for DVPOs for partner-abused minors. We detailed the content of each state’s laws and specific requirements, including self-petitioning, eligible age, dating relationship, and stalking. Additionally, we explored how statutes were interpreted by judicial and non-judicial branches of the governments and nonprofit victim service organizations, and searched other statutory provisions for states where the state statute on the DVPO eligibility for teen dating violence was unclear.

Findings:

Our findings indicate that state statutes vary in terms of whether minors can be granted DVPOs, whether they can self-petition without a guardian, whether a non-sexual romantic relationship is covered, and whether stalking is covered. Additionally, a variety of courts’ practices and governmental opinions pertaining to protection remedies for child abuse, sexual violence, harassment, or stalking and other statutory provisions other than DVPOs was found.

Discussion:

This research discusses the importance of more inclusive statutory revisions in each state, and the need to secure greater information accessibility to eligibility requirements, instructions, and procedures for obtaining a DVPO for minors.
Comparing Populist Media: From Fox News to the Young Turks, From Cable to YouTube, From Right to Left
Authors: Peck Reece
Published: August 2022

This article compares populist media styles on US cable news and in online video. It juxtaposes the conservative cable giant Fox News with the progressive YouTube-based network the Young Turks (TYT). TYT stands as one of YouTube’s longest running and most successful “news and politics” channels on the platform. This progressive digital network has long embraced a populist anchoring style that resembles Fox News and the style of its conservative YouTube competitors. This study establishes the stylistic affinity between TYT and Fox News and then explains how it is driven by a similar commercial-economic logic that prizes “loyal” viewership and “intense” engagement above all else. Shifting from political economy to media activism, this article also chronicles TYT’s role in creating the Justice Democrats, the progressive PAC that recruited Alexandria Ocasio-Cortez and other “Squad” members. This article seeks to complicate the commonly held association between populism and political conservatism.
Pathological Analysis and Clinical Evolution After Radiological Removal of Retrievable Vena Cava Filters
Authors: Annweiler Thierry , Bertoletti Laurent , Grange Sylvain , Peoc’h Michel , Mismetti Patrick , Barral Fabrice-Guy
Published: August 2022

Objective

Retrievable inferior vena cava filters (IVCF) have been developed because permanent filters have been associated with an increased risk of recurrent deep venous thrombosis. There is no data on the interactions of IVCF with the inferior vena cava (intrafilter thrombi, insertion through the venous wall) even though this may alter the course after retrieval of the IVCF.

Methods

A review of 85 consecutive patients undergoing retrieval of IVCF placed at a single center was performed from January 1, 2010 and December 31, 2014. Inferior vena cava filter were examined for presence of intrafilter thrombus at time of retrieval. Filter position and presence of intraluminal thrombus were examined. Patient outcomes, including recurrence of deep vein thrombosis (DVT) and death, were captured at 3 month followup.

Results

Eighty five patients were identified, with intrafilter thrombi found in 69 (81%) patients and venous wall fragments found in 75 (88%) patients. However, their presence was not associated with an increased risk of recurrent venous thromboembolism (VTE) or death during follow up.

Conclusions

Intrafilter thrombi and venous wall fragments are frequently found in removed IVCF but are not associated with a worse prognosis. They may not modify the therapeutic management of patients.
Laparoscopically Harvested Omental Flap for Immediate Total Breast Reconstruction; Lessons Learnt Through Ten-Year Experience in a Tertiary Oncology Center
Authors: Kahter Ashraf , Ghazy Hosam , Setit Ahmed , Shams Nazem , Gohar Omnia , Abdelwahab Khaled , Eldamshety Osama , Fathi Adel
Published: August 2022

Background. Most of the publications about Laparoscopically harvested omental flap after skin sparing mastectomy were case reports or case series. Most of them were designed for partial breast reconstruction and were lacking long-term follow-up for cosmetic results, oncologic safety, and detailed methodology. Our study aimed at highlighting the place of this method of reconstruction with long-term oncologic safety and cosmetic outcome. Methods. This study included 95 women who were candidates for skin-sparing mastectomy. Those with body mass index below 25 and above 40, those with omental resection or expected marked adhesions were excluded. All patients were consented to then undergo breast reconstruction using pedicled laparoscopically harvested omental flap. Results. The mean BMI was 34. The mean tumor size was 3.4 cm. The mean total operative time was 129 minutes. Inadequate volume occurred in 12 patients (13%). The mean total drainage output was 750 ml with 8.7% incidence of seroma. Partial breast envelop necrosis was encountered in 5 cases. Partial flap loss occurred in 2 patients. Fat necrosis occurred in 11 cases. Mastectomy and abdominal complications were accepted. Local recurrence was met in one patient and distant metastases occurred in 3 cases. 83.7% of patients expressed excellent and good aesthetic outcomes. Conclusion. When skin sparing mastectomy is chosen with suitable body mass index, laparoscopically harvested omental flap is a very safe and attractive option for total breast reconstruction with a minimal donor site morbidity, satisfactory cosmetic outcome with no compromise of the oncologic safety.
A Family-School Liaison’s Negotiation of Racialized Scripts for Family Engagement
Authors: Alvarado Jasmine
Published: August 2022

This case presents how a family-school liaison, Claudia Vasquez, attempts to cultivate deeper relationships between families and a bilingual elementary program. Two challenges that Claudia faces are the multiple roles and responsibilities placed upon her, as well as the lack of support from her school community toward engaging multiply-minoritized families. Viewed through the lens of racialized scripts, these challenges are manifestations of long-standing structures of institution, thought, and relationality that aim to uphold White supremacy.
Evaluation of Applicability of Novel Markers of Metabolic Syndrome in Adult Men
Authors: Tomasiuk Ryszard
Published: August 2022

There is a continuous worldwide increase in incidences of metabolic syndrome (MetS) reaching about a quarter of the world’s population. Thus, studies that allow for a robust diagnosis of MetS are of paramount importance from an economic and medical point of view. This study was carried out in a group of men diagnosed with MetS using consensus definition criteria that included the definitions of the International Diabetes Foundation and Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. The control group consisted of men for whom the parameters that define the MetS were in the norm. This study analyzed statistical differences between MetS and healthy men and the correlations between the set of 14 potential markers of MetS, that is, between body mass index, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein, triglycerides, cortisol, adiponectin, monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), adipsin, leptin, resistin, and plasminogen activator inhibitor-1 (PAI)-1. This report revealed a significant difference between MetS and healthy men in most of the parameters studied. Furthermore, a strong positive correlation between cortisol levels and body mass index was demonstrated. Furthermore, MCP-1 levels in men with MetS were significantly higher than their levels in healthy men. Finally, a strong positive correlation was also observed between adiponectin and adipsin in Mets men. Thus, this study reveals the potential usefulness of adiponectin, MCP-1, adipsin, leptin, resistin, and PAI-1 as markers of MetS in adult men.
The Ethical and Methodological Dilemma of Questioning the Truthfulness of a Participant’s Story: Using “Circulating Reference” to Enhance the Validity of Qualitative Research
Authors: Holter Marianne Therese Smogeli
Published: August 2022

The question of how to enhance validity in qualitative research has been thoroughly debated. In this debate, however, the truthfulness of participants’ stories is rarely questioned. But what do you do if you, while working within a critical realist perspective, come across a story that seems almost too incredible to be true? This dilemma of The Almost Too Incredible Story is ethical as well as methodological. In this article, I suggest that it is best handled by conceptualizing the process of qualitative inquiry in terms of Bruno Latour’s concept “circulating reference”. The dilemma is then addressed through a stepwise process starting with (1) analysing all material as if all were believed to be true; (2) retracing the role of the data you question through the study’s ladder of circulating reference; (3) retracing the role of the data in the researcher’s transformed understanding of the phenomenon; and (4) using the results of these steps to determine whether The Almost Too Incredible Story poses a genuine threat to the validity of the results. If the validity is threatened, the researcher may decide to (a) return to the participant to clarify; (b) trust and keep the story; (c) discard all the data from this participant from the analysis; or (d) discard only the data that does not align with other participants’ account. Through this systematic process, the researcher can determine the best course of action for keeping the research as truthful as possible while also honouring the participant’s contribution.
Ethnic affiliation and reentry difficulties and barriers among parolees
Authors: Shoham Efrat , Sha’ar-Efodi Rotem , Cojocaru Lutzy , Nicotra Eitan
Published: August 2022

The empirical literature on prisoners’ reentry process points to several obstacles they face upon release. This study focuses on the subjective perceptions of paroled prisoners in Israel regarding the difficulties they face and whether there is a difference between Jewish and Arab parolees regarding the significance they attribute to these difficulties. The study also compares these subjective perceptions of paroled prisoners to the perceptions of Prisoner Rehabilitation Authority workers regarding the difficulties released prisoners face on parole. The sample included 346 paroled prisoners and 75 Prisoner Rehabilitation Authority workers. The findings reveal significant gaps between the paroled prisoners and PRA workers regarding the importance they attributed to the reentry difficulties. Almost no significant differences were found between Jewish and Arab paroled prisoners. The current article offers several possible explanations for the gaps found regarding the significance of the difficulties accompanying the reintegration process.
The safety and effectiveness of endovascular treatment for patients with vertebrobasilar artery occlusions: according to the BEST and BASICS criteria
Authors: Sun Wen , Duan Zuowei , Xu Pengfei , Xiao Lulu , Wang Jinjing , Gui Wei , Luo Genpei , Wu Zhongyi , Han Zhongkui , Li Wei , Xu Guoqiang , Liu Fengchang , Yi Jilong , Liu Chaolai , Zhang Yan , Liu Haiyan
Published: August 2022

Background:

Whether endovascular treatment (EVT) is safe and effective for vertebrobasilar artery occlusion (VBAO) is yet incompletely understood. Two RCTs, the endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST) trail and the Basilar Artery International Cooperation Study (BASICS), concentrating on this field were recently reported.

Objective:

We use real-world registry data of VBAO to compare the outcome of EVT inside and outside the inclusion and exclusion criteria of the BEST and BASICS study to testify the feasibility of the selection paradigms of VBAO in these trials.

Methods:

Consecutive patients with VBAO receiving EVT involving 21 stroke centers were retrospectively included. The safety outcomes [3-month mortality, symptomatic intracranial hemorrhage (sICH), and effectiveness outcomes (the proportion of 3-month functional independence (mRS of 0–2) and favorable outcome (mRS of 0–3)] were compared between VBAO patients who meet or failed to meet the BEST/BASICS selection criteria for EVT.

Results:

Our study cohort consisted of 577 VBAO patients who underwent EVT. Of them, 446 patients had pc-ASPECTS ≧8. Successful reperfusion (mTICI 2b or 3) was achieved in 85.4% ( n = 493). There were 418 patients fulfilling the BEST criterion for EVT and 194 fulfilling the BASICS criterion. Regression analysis indicated that adherence to BEST or BASICS criterion for EVT was not independently related to most of the safety and effectiveness outcome except that adherence to BEST was significantly associated with the 3-month favorable outcome (ORBEST: 1.742, 95% CI: 1.087–2.790). However, when we put pc-ASPECTS into both criteria with a cut-off value of 8, meeting both BEST criterion plus pc-ASPECTS and BASICS criterion plus pc-ASPECTS was independently related to 3-month functional independence (ORBEST: 1.687, 95% CI: 1.077–2.644; ORBASIC: 1.653, 95% CI: 1.038–2.631) and favorable outcome (ORBEST: 2.280, 95% CI: 1.484–3.502; ORBASIC: 2.153, 95% CI: 1.372–3.378).

Conclusion:

Our study indicated that, based on real-world data of EVT, adherence to BEST or BASICS criterion for EVT was not independently associated with the safety and effectiveness outcome except that adherence to BEST was significantly related to the 3-month favorable outcome. However, the BEST or BASICS selection criterion and pc-ASPECTS ≧8 might be better paradigms for EVT patient selection.
Inequity and disparities mar existing global research evidence on Long COVID
Authors: Taghrir Mohammad Hossein , Akbarialiabad Hossein , Abdollahi Ashkan , Ghahramani Nasrollah , Bastani Bahar , Paydar Shahram , Razani Babak , Mwangi John , Asadi-Pooya Ali A. , Roozbeh Jamshid , Malekmakan Leila , Kumar Manasi
Published: August 2022

Since the pandemic began in December 2019, SARS-Cov2 has accentuated the wide gap and disparities in socioeconomic and healthcare access at individual, community, country, and regional levels. More than two years into the current pandemic, up to three-fourths of the patients are reporting continued signs and symptoms beyond the acute phase of COVID-19, and Long COVID portends to be a major challenge in the future ahead. With a comprehensive overview of the literature, we found that most studies concerning long COVID came from high and upper-middle income countries, and people of low-income and lower-and-middle income regions and vulnerable groups with comorbid conditions have been neglected. Apart from the level of income, there is a significant geographical heterogeneity in investigating the Post-Acute Sequelae of COVID-19 (PASC) or what we call now, long COVID. We believe that these recognizing health disparities is crucial from equity perspective and is the first step toward global health promotion.
The influence of firm-Generated video on user-Generated video: Evidence from China
Authors: Ma Zirui , Gu Bin
Published: August 2022

We examined the impact of firm-generated content on firm-related user-generated content. Researches have proven that firm-related user-generated content impacts firm revenue. Therefore, it is necessary to determine what factors stimulate the creation of firm-related user-generated content. Creating user-generated videos related to companies (e.g. E-sports) on Chinese online video platforms often includes the use of firm-generated videos as material. It may suggest that firm-generated content may play an essential role in influencing Internet users to create firm-related user-generated content. We collected a unique dataset using a Python web crawler and used the LSDV model for empirical analysis, including 2977 firm-generated videos and 49860 user-generated videos, to explore the impact of firm-generated video attributes on user-generated videos. The results show that some attributes of firm-generated video have a significant impact on user-generated video. The number of comments and coins on firm-generated videos positively affects user-generated videos, while the number of favorite on firm-generated videos negatively affects user-generated videos. We also found that the difference in how users feel about firm-generated videos affects the likelihood of users creating their original videos. User engagement and user brand identity in FGV positively impact stimulating user-generated videos. The authors suggest that companies can maximize the impact on user-generated content by targeting the creation of firm-generated content based on these video attributes. The authors also suggest that firms further investigate theories related to motivational factors, such as the impact of consumer engagement, brand identity, and perceived usefulness on user-generated content.
Using Guided Critical Reflection to Discover Deepened and Transformative Learning in Leadership Education
Authors: Sweet Sequetta F.
Published: August 2022

This qualitative study used guided critical reflection as a pedagogical strategy to explore transformative learning and leadership development of students in a leadership doctoral program. In written reflections after a weekend of classes, students ( N = 19) reflected using carefully constructed questions to focus their thinking. The reflections were analyzed through the lens of transformative learning theory. Students noted increased self-awareness, questioned their assumptions/beliefs, experienced shifts in their mindsets, and were moved to action/proposals for action. Guided critical reflection, then, is presented as a viable learning strategy for leadership development. The transformative learning process aligns with the critical reflection process.
Malnutrition among under-five children in St. Martin’s Island, Bangladesh: A cross-sectional study on prevalence and associated factors
Authors: Jubayer Ahmed , Islam Md Hafizul , Nayan Md Moniruzzaman
Published: August 2022

Objectives:

Early childhood nutrition is critical for physical and mental development, and any hindrance (malnutrition) at this stage adversely affects adulthood which makes them more susceptible to a variety of communicable and non-communicable diseases. St. Martin’s Island was the focus of this study, which examined the prevalence and risk factors for malnutrition among under-five children.

Methods:

In this cross-sectional study, 256 children aged under five were assessed for anthropometry, and multiple logistic regression models were fitted to identify potential predictors of malnutrition. For analysis, SPSS and WHO Anthro software were used.

Results:

The prevalence of stunting, wasting, underweight, and overweight were 34.4%, 17.6%, 18.9%, and 6.9% respectively among children under-five years of age in St. Martin’s Island. An increase in child’s age decreases their risk of being stunted (AOR = 0.97, p = 0.006). Males were more likely than females to be wasted (AOR = 2.03, p = 0.001). Both stunting (AOR = 2.42, p = 0.004) and wasting (AOR = 2.82, p = 0.015) rate were higher among the poorer section as compared to the richest. On the contrary, underweight was low among the poorest section (AOR = 0.37, p = 0.024). Other socio-economic factors, for example, household food insecurity, and parental occupation affect these forms of malnutrition significantly.

Conclusion:

Prevalence of all forms of malnutrition except underweight was higher as compared to the national perspective in St. Martin’s Island among the under-five children. Community-based approaches by the local government in collaboration with various non-government organizations should be taken to reduce and prevent malnutrition among children.
Differentiating Problematic from Habitual Instagram Use: A Uses and Grats 2.0 Perspective
Authors: Chen Cheng , Cohen Olivia , Sundar S. Shyam
Published: August 2022

The popularity of Instagram among young adults has raised concerns about the excessive use of Instagram. Is it the kind of problematic media use that takes over one’s life or just habitual ritualized use characterized by mindless scrolling? How can we differentiate between the two based on the use of Instagram features and perceived gratifications from the technology itself? Drawing on the theoretical framework of Uses and Gratifications (U&G) and U&G 2.0, we conducted a survey study ( N  = 482) to answer these questions. Our findings show that habitual Instagram use is positively related to the use of lurking- and connection-related features and the gratification of play. By contrast, problematic Instagram use is positively correlated with the use of broadcasting-related features and the gratification of novelty. Theoretical implications for differentiating problematic from habitual Instagram use and practical implications for designing ethical interfaces, which consider the digital well-being of users, are discussed.
Disability, Discrimination, and Mental Health during the COVID-19 Pandemic: A Stress Process Model
Authors: Brown Robyn Lewis , Ciciurkaite Gabriele
Published: August 2022

Drawing on data from a community survey with a sizeable subsample of people with physical, intellectual, and psychological disabilities in the Intermountain West region of the United States ( N = 2,043), this investigation examined the association of social stressors stemming from the COVID-19 pandemic with ableism or disability-related discrimination. We further assessed the significance of these associations for variation by disability status in psychological well-being with a moderated mediation analysis. Study findings provide clear evidence that greater pandemic-related stressor exposure was associated with greater discrimination, which in turn increased the psychologically distressing aspects of the pandemic for people with disabilities relative to people without disabilities. This set of findings challenges us to think about how we engage in research concerning ableism and the proliferation of macro-level stressors such as those associated with the COVID-19 pandemic. The findings also support the application of a minority stress model in addressing mental health contingencies among people with disabilities—in this case, in examining the pandemic’s psychological impact.
Workplace Age Discrimination and Social-psychological Well-being
Authors: Roscigno Vincent J. , Zheng Hui , Crowley Martha
Published: August 2022

The research literature on workplace inequality has given comparatively little attention to age discrimination and its social-psychological consequences. In this article, we highlight useful insights from critical gerontological, labor process, and mental health literatures and analyze the patterning of workplace age discrimination and its implications for sense of job insecurity, job-specific stress, and the overall mental health of full-time workers 40 years old and above, covered by the Age Discrimination in Employment Act (ADEA). Our analyses, which draw on two decades and five waves of the General Social Survey (2002–2018), reveal (1) the prevalence of self-reported workplace age discrimination and growing vulnerability particularly for those 60 years and above, (2) clear social-psychological costs when it comes to job insecurity, work-specific stress, and overall self-reported mental health, and (3) dimensions of status and workplace social relations that offer a protective buffer or exacerbate age discrimination’s corrosive effects. Future research on age as an important status vulnerability within the domain of employment and the implications of unjust treatment for well-being and mental health are clearly warranted.
Building a Conscientious Personality is Not Sufficient to Manage Behavioral Biases: An Effective Intervention for Financial Literacy in Women Entrepreneurs
Authors: Iram Tahira , Bilal Ahmad Raza , Ahmad Zeshan , Latif Shahid
Published: August 2022

The purpose of this study is to examine the impact of Consciousness personality on women entrepreneurs’ behavioral biases by focusing on financial literacy which is taken as a mediator while the mindfulness as a potential moderator. A random sample of 210 female entrepreneurs working in Pakistan was collected through stratified sampling technique and data are analyzed by using Structural Equation Modeling through SMART-PLS. The results divulged a significant mediating impact of financial literacy in reducing mental accounting bias among consciousness personality possessing women entrepreneurs; however, financial literacy was found related to the risk aversion bias through mindfulness. The moderation analysis further revealed interesting indirect impacts, such that financial literacy strongly reduced mental accounting and risk aversion bias for women who were more conscious of proper financial mindfulness. Nonetheless, financial mindfulness did not catalyze financial literacy and herding bias relationship. By encompassing the concepts of financial literacy, mindfulness, and behavioral biases in consciousness personality’s women entrepreneurs, we offered a comprehensive theoretical framework with practical implications for women entrepreneurs in Pakistan. Thus, we suggest new avenues for the longstanding dilemma related to the factors instigating suboptimal financial decision-making in women entrepreneurs in developing markets.
Study protocol to determine the effects of solvents on lung function among paint industry workers in Mauritius: A cross-sectional study
Authors: Yusuf Khan Yarroo Mohammad , Rathebe Phoka C
Published: August 2022

Background:

The effects of exposure to solvents in paints have been widely studied, but very little information is at hand with only a small number of studies carried out on pulmonary function of paint industry workers. The aim of this study is to determine the respiratory effects of exposure to solvents among workers of the paint industry in Mauritius.

Design and methods:

A quantitative cross-sectional study will be conducted in three paint factories across Mauritius. 388 participants would be selected using simple random sampling and be subjected to a pre-designed questionnaire for data collection. Lung function test using a spirometer will also be conducted. Data analysis will be performed using Statistical Package for Social Sciences (SPSS v26.0). The exposed workers will be classified by shift duration, that is, individuals with weekly solvent exposure of ≤12 and >12 h respectively. Using multivariable regression analysis, odds ratio will be calculated to analyze the relationship between the dependent variable (hours of exposure to solvents) and independent variables while adjusting for socio-demographic factors. Independent t-test will also be used to identify any difference between the means of lung function tests and the two exposure groups. Based on pre-observation in the three paint industries, it is anticipated that male workers could be found less likely to be exposed to solvents as compared to female workers. Also, workers with a level of education below secondary and lower secondary categories could have a higher likelihood of being exposed ≤12 h/week shift. Those who are aware of occupational hazards and could indicate to have used personal protective equipment (PPE) could be less likely exposed to solvents.

Expected Impact of the study for Public Health:

This study has been approved by the Ethics Committee of the Faculty of Health Sciences at the University of Johannesburg- ethics clearance number: REC-919-2021. The results of this study will be made available to all stakeholders involved in Health and Safety in the Mauritius. Meetings with professional in the field, especially the concerned paint factories, have been arranged to discuss the impact of solvent exposure and propose remedial actions to protect the workers.
Secondary Extramedullary Myeloma of the Gallbladder: A Case Report
Authors: Kolagatla Sandhya , Jenkins Joshua K. , Strunk Haley , Smith Forrest , Ganti Subramanya Shyam , Moka Nagabhishek
Published: August 2022

Extramedullary myeloma (EMM) is an infrequent but well-established manifestation of multiple myeloma (MM), defined as a soft tissue plasma cell neoplasm without bone marrow involvement. Gallbladder involvement in EMM, however, is a very rare occurrence, with only 8 cases found in the English medical literature. Here, we present a case of an older adult male with a gallbladder mass in the presence of increasing serum kappa light chains after a normal bone marrow biopsy confirmed the complete remission of a previous MM diagnosis. Histopathologic evaluation of a biopsied sample confirmed the mass as an atypical plasma cell neoplasm. Later in his treatment, he developed several firm, smooth, violaceous skin nodules on the torso, which histopathology confirmed as also being atypical plasma cell neoplasms. We aim to contribute to the medical literature by expanding the pool of information regarding EMM of the gallbladder to support future diagnostic and treatment recommendations.
Haredi Anti-Zionist Ideology as the Driving Force Behind the Ultraorthodox Protests in Israel
Authors: Hitman Gadi
Published: August 2022

Since its establishment as an independent state, Israel has witnessed waves of protests, sometimes violence, from the Haredi (ultraorthodox) community. Focusing on clashes between Haredi protesters and the police from 2000 onward, this study suggests a new theoretical explanation for Haredi protests and violent activities. By using a mixture of the following three major theories—primordial, constructivism, and contingency—the article provides a new model for analyzing Haredi patterns of confrontation with the Israeli authorities. It concludes, inter alia, that the Haredi community is a permanent passive protest movement that responds, usually immediately, to official initiatives to change the status quo involving the state, politics, society, and religion in Israel.
Towards a 15-minute city: A network-based evaluation framework
Authors: Zhang Shanqi , Zhen Feng , Kong Yu , Lobsang Tashi , Zou Sicong
Published: August 2022

Developing 15-minute cities, where people can access to living essentials within a 15-minute trip, has become a global effort. In addition to practical exercise, researchers have paid attention to the evaluation of 15-minute cities using home-based accessibility approaches. However, existing approaches do not account for human mobility, an important indicator of how people access and interact with urban amenities. In this study, we propose a novel network-based framework that assesses a 15-minute city considering human mobility patterns. We assume that there exists an optimal mobility network, which would maximize human mobility under the constraints of the current distribution of amenities. Locations where the provision of urban amenities does not match local needs are first identified based on the comparison between optimal mobility patterns and their actual counterparts. Built environment, demographic, and network structure factors that contribute to identified mismatch issues are then examined. The empirical study of Nanjing, China, suggests that the proposed framework could enable a dynamic evaluation of 15-minute cities and could provide important insights on policies and intervention strategies of planning and developing 15-minute cities.
Entrepreneurship Education as a Vehicle for K-12 Inclusion: A Case with Boys & Girls Clubs of America
Authors: Slatten Lise Anne , Stewart Geoffrey , Lanier Patricia , Credo Keith R. , Bendickson Joshua S.
Published: August 2022

This learning innovation offers a model by which university faculty can increase community engagement, provide greater opportunities to under-served populations, and advance inclusive programming in entrepreneurship education. We present a learning innovation to enhance working with local K-12 focused nonprofit organizations to positively influence individuals, communities, and local entrepreneurship ecosystems.
Effects of a 12-Week Periodized Resistance Training Program on Resting Brain Activity and Cerebrovascular Function: A Nonrandomized Pilot Trial
Authors: Macaulay Timothy R , Hegarty Amy , Yan Lirong , Duncan Dominique , Pa Judy , Kutch Jason J , La Rocca Marianna , Lane Christianne J , Schroeder E Todd
Published: August 2022

Resistance training is a promising strategy to promote healthy cognitive aging; however, the brain mechanisms by which resistance training benefits cognition have yet to be determined. Here, we examined the effects of a 12-week resistance training program on resting brain activity and cerebrovascular function in 20 healthy older adults (14 females, mean age 69.1 years). In this single group clinical trial, multimodal 3 T magnetic resonance imaging was performed at 3 time points: baseline (preceding a 12-week control period), pre-intervention, and post-intervention. Along with significant improvements in fluid cognition ( d = 1.27), 4 significant voxelwise clusters were identified for decreases in resting brain activity after the intervention (Cerebellum, Right Middle Temporal Gyrus, Left Inferior Parietal Lobule, and Right Inferior Parietal Lobule), but none were identified for changes in resting cerebral blood flow. Using a separate region of interest approach, we provide estimates for improved cerebral blood flow, compared with declines over the initial control period, in regions associated with cognitive impairment, such as hippocampal blood flow ( d = 0.40), and posterior cingulate blood flow ( d = 0.61). Finally, resistance training had a small countermeasure effect on the age-related progression of white matter lesion volume (rank-biserial = −0.22), a biomarker of cerebrovascular disease. These proof-of-concept data support larger trials to determine whether resistance training can attenuate or even reverse salient neurodegenerative processes.
aRNAque: an evolutionary algorithm for inverse pseudoknotted RNA folding inspired by Lévy flights
Authors: Merleau Nono S. C. , Smerlak Matteo
Published: August 2022

Background

We study in this work the inverse folding problem for RNA, which is the discovery of sequences that fold into given target secondary structures.

Results

We implement a Lévy mutation scheme in an updated version of an evolutionary inverse folding algorithm and apply it to the design of RNAs with and without pseudoknots. We find that the Lévy mutation scheme increases the diversity of designed RNA sequences and reduces the average number of evaluations of the evolutionary algorithm. Compared to , CPU time is higher but more successful in finding designed sequences that fold correctly into the target structures.

Conclusion

We propose that a Lévy flight offers a better standard mutation scheme for optimizing RNA design. Our new version of is available on GitHub as a python script and the benchmark results show improved performance on both and the datasets, compared to existing inverse folding tools.