bluuebunny/crossref_metadata_2025 huggingface dataset:
POTENSI ANCAMAN PADA BANGUNAN CAGAR BUDAYA BANUA LAYUK RAMBU SARATU DI MAMASA SULAWESI BARAT
Authors: Mulyadi Yadi , Makkaraka Iswadi A.
Published: January 2019

Banua Layuk Rambu Saratu merupakan rumah tradisional Mamasa yang telah ditetapkan sebagai Cagar Budayaperingkat Provinsi Sulawesi Barat sejak 2015. Bangunan cagar budaya ini telah berusia ratusan tahun, dengan kontruksidari kayu sebagai tiang, papan, dan lantai rumahnya. Faktor usia dan material yang dipergunakan menjadikan BanuaLayuk Rambu Saratu memiliki potensi ancaman kerusakan yang tinggi. Berdasarkan hasil pengamatan dan wawancara dilaangan,terdaatduamacamancamanyangdaatdiidentikasi.Ancamanyangertamaadalahancamannon-sikdanancamanyangkeduaadalahancamansik.enelitianinidifokuskanadauayamemetakanotensiancamanterhadabangunan Banua Layuk Rambu Saratu, sehingga dapat dijadikan acuan dalam merancang tindakan konservasi sebagaiupaya pelestarian Banua Layuk Rambu Saratu.
PERUBAHAN DAN ANCAMAN BENTENG KERATON BUTON DI KOTA BAU-BAU SULAWESI TENGGARA
Authors: Susanti Dewi
Published: January 2019

Benteng Keraton Buton berada di jalan Sultan Labuke, Kelurahan Melai, Kecamatan Murhum, Kota Bau-Bau.Metode yang digunakan dalam tulisan ini adalah pengumpulan data berupa pengumpulan data pustaka, dan pengamatanlangsung di lapangan. Tahap selanjutnya adalah pengolahan data, tahapan ini dilakukan untuk mempermudah dalamproses analisis data yang telah diperoleh dan dapat menjadi dasar untuk menentukan upaya-upaya penanganan yang akandilakukan. Tulisan ini mencoba menglasikasikan ancaman yang terjadi ada Kawasan Benteng Keraton Buton dan upaya yang bisa ditawarkan. Kondisi Benteng Keraton Buton telah banyak mengalami perubahan baik dari lahan maupunbangunan. Perubahan yang terjadi mengakibatkan terjadinya kerusakan pada beberapa kondisi asli dari Benteng KeratonButon. Perubahan yang terjadi pada lingkungan dan bangunan yang ada di dalam kawasan Benteng Keraton Buton berupaperluasan pemukiman, perluasan lahan pertanian, pemakaman, modernisasi, dan kebijakan pemerintah. Upaya untukmencegah terjadi erubahan yang lebih signikan ada Benteng Keraton Buton yaitu melalui uaya elindungan dalam bentuk zonasi dengan tujuan dengan adanya zonasi maka pemanfaatan ruang dan bangunan dapat diatur sesuai denganperuntukannya.
Konservasi Cagar Budaya Kayu Dengan Asap Cair (Uji Lapangan)
Authors: . Moh. Habibi
Published: January 2019

Dalam penelitian ini dievaluasi efektivitas asap cair untuk pengawetan kayu pada skala lapangan (graveyardtest). Variabel bebas pada kajian ini meliputi konsentrasi asap cair (0%, 10%, 20%, 30%, 50%, 100%, Termicon),jenis kayu (Jati & Nangka), dan teknik aplikasi (oles & semprot). Variabel terikat yang diamati adalah berat kayuuji dan kualitas mutu kayu (tingkat kerusakan kayu akibat serangan rayap). Pengujian skala lapangan dilakukandengan mengubur sampel kayu selama dua bulan. Hasil kajian menujukkan bahwa hanya konsentrasi asap cairyang berpengaruh nyata terhadap ketahanan kayu uji dari rayap tanah. Konsentrasi 100% memberikan pengaruhberbeda nyata dibandingkan dengan konsentrasi yang lain serta memberikan kualitas mutu kayu yang terbaik.
Striking a Balance in Contract Interpretation: The Primacy of the Text
Authors: Catterwell Ryan
Published: January 2019

In Wood v Capita Insurance Services Ltd [2017] AC 1173, the UK Supreme Court emphasised that contract interpretation involves ‘striking a balance between the indications given by the language and the implications of the competing constructions’. This paper investigates the nature of the balancing act at the heart of construction. It argues that the balancing exercise is easier to comprehend if construction is understood in a particular way, namely, as a technique employed to infer objective intention from the choice of words in a contract. The admissible factors—ie, the potential meanings for the words, the background, the purpose of the contract and the consequences of the potential interpretations—serve as indicators of intention. The composition and relative strength of the competing considerations ultimately determines the resolution of the dispute. Often, the objective intention of the parties is found in the complexities and implications of the contract text.
Compact and Broadband Microstrip Band-Stop Filters with Single Rectangular Stubs
Authors: Kusama Yusuke , Isozaki Ryota
Published: January 2019

In this research, a compact and broadband microstrip line quarter-wavelength open circuited stub, which is the core of the band-stop filter, is studied from the viewpoint of the characteristic impedance ratio between the main transmission line and the stub line. Furthermore, a circuit pattern in which an inductive diaphragm is inserted at the stub attachment point using a stepped impedance structure is examined, and an evaluation of frequency adjustment and miniaturization is investigated. The results are compared with the well-known radial stub. Good agreement was obtained between the measured and simulated values up to 5 GHz. Good stop bandwidth was obtained, and the validity of the proposed method is confirmed. The application to other frequency bands is straightforward. The proposed structure is applicable as an alternative to the existing radial stub used for bias T to prevent the reverse flow of the Radio frequency (RF) signal to direct current (DC) source. It is also applicable for the waveguide E-plane band-stop filter, for preventing unwanted leakage from narrow gaps by substituting to a short-circuited stub with a capacitive window, by using the same approach used in the microstrip line H-plane discontinuity.
Determinants of Farmers’ Decisions on Risk Coping Strategies in Rural West Java
Authors: Mutaqin Dadang Jainal
Published: January 2019

The impact of natural hazards on agriculture in Indonesia is becoming increasingly severe. Therefore, improving farmers’ capacity to undertake risk coping strategies is essential to maintaining their prosperity. The objective of this study was to investigate the determinants of farmers’ decisions on ex ante and ex post coping strategies in rural West Java, Indonesia. The study was based on a field survey of 180 farmers conducted in the Garut district from July to October 2017. The study used the protection motivation theory framework and applied three econometric models: binomial logit model, zero truncated Poisson regression model, and multinomial logit model. Most farmers (74.4%) adopted ex ante coping strategies. They were characterized as having higher risk aversion per capita expenditure and disaster experience, but lower discount rates and percentage of damage and locations in downstream and midstream areas. Coping appraisal perceptions were found to be important factors in the risk coping analysis. Four determinants of the decision on the number of ex ante coping strategies adopted were: per capita expenditure, land size, disaster experience, and access to financial institutions. The most common ex post coping strategy adopted by farmers was the middle-stress type.
Optimized Dimensioning and Operation Automation for a Solar-Combi System for Indoor Space Heating. A Case Study for a School Building in Crete
Authors: Katsaprakakis Dimitris Al. , Zidianakis Georgios
Published: January 2019

This article investigates the introduction of hybrid power plants for thermal energy production for the indoor space heating loads coverage. The plant consists of flat plate solar collectors with selective coating, water tanks as thermal energy storage and a biomass heater. A new operation algorithm is applied, maximizing the exploitation of the available thermal energy storage capacity and, eventually, the thermal power production from the solar collectors. An automation system is also designed and proposed for the realization of the newly introduced algorithm. The solar-combi system is computationally simulated, using annual time series of average hourly steps. A dimensioning optimization process is proposed, using as criterion the minimization of the thermal energy production levelized cost. The overall approach is validated on a school building with 1000 m2 of covered area, located in the hinterland of the island of Crete. It is seen that, given the high available solar radiation in the specific area, the proposed solar-combi system can guarantee the 100% annual heating load coverage of the examined building, with an annual contribution from the solar collectors higher than 45%. The annually average thermal power production levelized cost is calculated at 0.15 €/kWhth.
Collective Trauma and Mystic Dreams in Zabuzhko’s “The Museum of Abandoned Secrets”
Authors: Lenherr Mariia
Published: January 2019

The 20th century of human history was overshadowed by the horrifying events of world wars and totalitarian regimes, with their traumatic experiences becoming the very focus of today’s modern globalized society. Psychoanalytic psychotherapy is one of the ways of dealing with this overwhelmingly violent phenomenon. This article will discuss an historical traumatic event through literature, using psychoanalytic theories of trauma. The problem is discussed on the level of the actual theoretical landscape including the relation between transgenerational transmitted trauma, collective trauma, and cumulative trauma inscribed in a “foundation matrix” (Foulkes). As a clinical vignette, the novel “Museum of Abandoned Secrets” by modern Ukrainian writer Oksana Zabuzhko is used. The author addresses the functions of dreams, scrutinizing the psychodynamics of the novel using concepts of projective identification, mourning, the need for repair, and epigenetic and fractal theory. It is suggested that the novel facilitates the characters’ journey through trauma and its integration by the large groups (of readers).
Nostalgia, Motherhood, and Adoption: Two Contemporary Swedish Examples
Authors: Ahlin Lena
Published: January 2019

This paper explores the notion of nostalgia in two recent Swedish narratives of transnational adoption: Christina Rickardsson’s Sluta aldrig gå, 2016, (published in English as Never Stop Walking in 2017), and Cilla Naumann’s Bära barnet hem (“Carrying the Child Home”, 2015). The two narratives deal with adoption from South America to Sweden, include autobiographical content, and enable a comparison between an adoptee memoir (Rickardsson) and a parent-authored text (Naumann). Both texts center on maternal images, but the analysis suggests that Rickardsson’s narrative echoes the borderland nostalgia characteristic of adoptee writing. The adoptee memoirs, being reflective in mode and restorative in purpose, occupy a borderland between the two forms of nostalgia described by Boym (2001), while interrogating the temporal, spatial and affiliative boundaries of transnational adoption. Naumann’s nostalgic enterprise incorporates the mirrors, doubles and ghosts of reflective nostalgia. These representations are a fruitful means to represent the “other” family, and the alternative lives that were left behind in the process of adoption. Ultimately, her text suggests the limitations of the autobiographical mode and illustrates the capacity of fiction to provide a symbolic register in which to articulate the unspeakable aspects of adoption.
New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines
Authors: Kowalski Szymon , Wyrzykowski Dariusz , Hac Stanislaw , Rychlowski Michal , Radomski Marek Witold , Inkielewicz-Stepniak Iwona
Published: January 2019

Pancreatic cancer is characterized by one of the lowest five-year survival rates. In search for new treatments, some studies explored several metal complexes as potential anticancer drugs. Therefore, we investigated three newly synthesized oxidovanadium(IV) complexes with 2-methylnitrilotriacetate (bcma3−), N-(2-carbamoylethyl)iminodiacetate (ceida3−) and N-(phosphonomethyl)-iminodiacetate (pmida4−) ligands as potential anticancer compounds using pancreatic cancer cell lines. We measured: Cytotoxicity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), neutral red (NR) and lactate dehydrogenase (LDH) assay; antiproliferative activity by bromodeoxyuridine BrdU assay; reactive oxygen species (ROS) generation and cell cycle analysis by flow cytometry; protein level by Western blot and cellular morphology by confocal laser scanning microscopy. The results showed that these oxidovanadium(IV) complexes were cytotoxic on pancreatic cancer cells (PANC-1 and MIA PaCa2), but not on non-tumor human immortalized pancreas duct epithelial cells (hTERT-HPNE) over the concentration range of 10–25 μM, following 48 h incubation. Furthermore, molecular mechanisms of cytotoxicity of [4-NH2-2-Me(Q)H][VO(bcma)(H2O)]2H2O (T1) were dependent on antiproliterative activity, increased ROS generation, cell cycle arrest in G2/M phase with simultaneous triggering of the p53/p21 pathway, binucleation, and induction of autophagy. Our study indicates that oxidovanadium(IV) coordination complexes containing 2-methylnitrilotriacetate ligand are good candidates for preclinical development of novel anticancer drugs targeting pancreatic cancer.
Investigation of the AQP Family in Soybean and the Promoter Activity of TIP2;6 in Heat Stress and Hormone Responses
Authors: Feng Zhi-Juan , Liu Na , Zhang Gu-Wen , Niu Fu-Ge , Xu Sheng-Chun , Gong Ya-Ming
Published: January 2019

Aquaporins (AQPs) are one diverse family of membrane channel proteins that play crucial regulatory roles in plant stress physiology. However, the heat stress responsiveness of AQP genes in soybean remains poorly understood. In this study, 75 non-redundant AQP encoding genes were identified in soybean. Multiple sequence alignments showed that all GmAQP proteins possessed the conserved regions, which contained 6 trans-membrane domains (TM1 to TM6). Different GmAQP members consisted of distinct Asn-Pro-Ala (NPA) motifs, aromatic/arginine (ar/R) selectivity filters and Froger’s positions (FPs). Phylogenetic analyses distinguished five sub-families within these GmAQPs: 24 GmPIPs, 24 GmTIPs, 17 GmNIPs, 8 GmSIPs, and 2 GmXIPs. Promoter cis-acting elements analyses revealed that distinct number and composition of heat stress and hormone responsive elements existed in different promoter regions of GmAQPs. QRT-PCR assays demonstrated that 12 candidate GmAQPs with relatively extensive expression in various tissues or high expression levels in root or leaf exhibited different expression changes under heat stress and hormone cues (abscisic acid (ABA), l-aminocyclopropane-l-carboxylic acid (ACC), salicylic acid (SA) and methyl jasmonate (MeJA)). Furthermore, the promoter activity of one previously functionally unknown AQP gene-GmTIP2;6 was investigated in transgenic Arabidopsis plants. The beta-glucuronidase (GUS) activity driven by the promoter of GmTIP2;6 was strongly induced in the heat- and ACC-treated transgenic plants and tended to be accumulated in the hypocotyls, vascular bundles, and leaf trichomes. These results will contribute to uncovering the potential functions and molecular mechanisms of soybean GmAQPs in mediating heat stress and hormone signal responses.
Understanding Land in the Context of Large-Scale Land Acquisitions: A Brief History of Land in Economics
Authors: De Maria Marcello
Published: January 2019

In economics, land has been traditionally assumed to be a fixed production factor, both in terms of quantity supplied and mobility, as opposed to capital and labor, which are usually considered to be mobile factors, at least to some extent. Yet, in the last decade, international investors have expressed an unexpected interest in farmland and in land-related investments, with the demand for land brusquely rising at an unprecedented pace. In spite of a fast-growing literature analyzing the variety of “spaces” affected by large-scale land acquisitions (LSLAs), the contemporary process of “commodification” of land embedded in this phenomenon has taken present day economists by surprise. This paper reviews the evolution over time of the concept of land in economics and it suggests how different aspects of this evolution are relevant to the understanding of contemporary LSLAs. Rather than presuming to analyze in a systematic and comprehensive manner the immense literature in land economics, this article investigates what makes land a peculiar and complex commodity. Indeed, different branches of economic thought, at different moments in time, pointed out that the location of land in space matters; that land is a living and fundamental component of the ecosystem; that it is a valuable economic asset, and yet, it is often hard to value it in pure monetary terms; eventually, that land is intrinsically connected to societies, cultural and spiritual identities, mores, and institutions. Through a brief history of the evolution of the concept of land in economics, this paper identifies four broad categories—namely, space, economics, environment, and institutions—that help understanding land as a peculiar good. These four elements characterize land as a commodity, as well as its peculiarities, and constitute the prerequisites of a conceptual framework for the analysis and the understanding of the forces at play in the contemporary wave of large-scale land acquisitions.
Biocompatibility Characteristics of Titanium Coated with Multi Walled Carbon Nanotubes—Hydroxyapatite Nanocomposites
Authors: Park Jung-Eun , Jang Yong-Seok , Bae Tae-Sung , Lee Min-Ho
Published: January 2019

Multi walled carbon nanotubes-hydroxyapatite (MWCNTs-HA) with various contents of MWCNTs was synthesized using the sol-gel method. MWCNTs-HA composites were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). HA particles were generated on the surface of MWCNT. Produced MWCNTs-HA nanocomposites were coated on pure titanium (PT). Characteristic of the titanium coated MWCNTs-HA was evaluated by field-emission scanning electron microscopy (FE-SEM) and XRD. The results show that the titanium surface was covered with MWCNTs-HA nanoparticles and MWCNTs help form the crystalized hydroxyapatite. Furthermore, the MWCNTs-HA coated titanium was investigated for in vitro cellular responses. Cell proliferation and differentiation were improved on the surface of MWCNT-HA coated titanium.
The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
Authors: Lee Deok-Won , Hyun Hoon , Lee Sungsu , Kim So Yeon , Kim Gyu-Tae , Um Sewook , Hong Sung Ok , Chun Heung Jae , Yang Dae Hyeok
Published: January 2019

Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.
Acknowledgement to Reviewers of Medical Sciences in 2018
Authors: Medical Sciences Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides
Authors: Pham Thu Huong , Vidal Natalia P. , Manful Charles F. , Fillier Tiffany A. , Pumphrey Ryley P. , Doody Karen M. , Thomas Raymond H.
Published: January 2019

Fatty acid esters of hydroxy fatty acids (FAHFA), diglycerides (DG) and monoacetyldiglycerides (MAcDG) are gaining interest as functional lipids in pharmaceuticals and functional food formulations for managing and treating metabolic or inflammatory diseases. Herein, we investigated whether the antler and/or meat of two Cervids (moose and caribou) are novel sources of FAHFA, DG and MAcDG. We observed FAHFA present in moose and caribou composed mainly of polyunsaturated families, and that the esterification occurred frequently at the C5-hydroxy fatty acid moiety, most noticeably arachidonic acid 5-hydroxyeicosatrienoic acid (ARA-5-HERA). Moose antler, caribou and moose meat also contained significant levels of both 1,2-DG and 1,3-DG lipids. The 1,3-DG molecular species consisted mainly of 16:0/18:1, 18:0/16:0, and 18:0/18:1. On the other hand, major 1,2-DG species consisted of DG 18:0/18:0, 16:0/16:0 and 18:1/18:1 molecular species with higher levels in the antler compared to the meat. The molecular species composition of MAcDG was very simple and consisted of 14:2/18:2/2:0, 16:0/18:2/2:0, 16:0/18:1/2:0 and 18:0/18:1/2:0 with the first species 14:2/18:2/2:0 predominating in the tip of moose antlers. Increasing access to and knowledge of the presence of these functional lipids in foods will enhance their intake in the diet with potential implications in improving personal and population health.
Modulatory Effect of Guinep (Melicoccus bijugatus Jacq) Fruit Pulp Extract on Isoproterenol-Induced Myocardial Damage in Rats. Identification of Major Metabolites Using High Resolution UHPLC Q-Orbitrap Mass Spectrometry
Authors: Nwokocha Chukwuemeka , Warren Isheba , Palacios Javier , Simirgiotis Mario , Nwokocha Magdalene , Harrison Sharon , Thompson Rory , Paredes Adrian , Bórquez Jorge , Lavado Astrid , Cifuentes Fredi
Published: January 2019

Guinep is traditionally used in the management of cardiovascular ailments. This study aims to evaluate its medicinal constituents and effects in the management of myocardial injury in an experimental isoproterenol (ISO) rat model. Sprague-Dawley rats were randomly assigned to four groups: Group 1 was the control group; Group 2 received M. bijugatus extract (100 mg/Kg; MB) for six weeks; Group 3 was given ISO (85 mg/Kg) i.p. twice during a 24-hour period; and Group 4 was given ISO (85 mg/Kg) i.p. and MB extract (100 mg/Kg) for six weeks. The MB was administered orally by gavage, daily. The blood pressure of conscious animals was measured, while ECG was performed under anesthesia. Blood and serum were collected for biochemical and hematological analysis. The ISO group treated with MB showed a significant decrease (p < 0.001) in (SBP), diastolic (DBP), mean arterial (MAP) and heart rate (HR) compared to the ISO only group. Conversely, MB treated rats that were not induced with ISO displayed a significant decreases (p < 0.001) in SBP, DBP, MAP, and HR. ISO significantly elevated the ST segment (p < 0.001) and shortened the QTc interval (p < 0.05), which were recovered after treatment with 100 mg/Kg of MB. In addition, the results showed a significant decrease (p < 0.001) in the heart to body weight ratio of the ISO group treated with MB compared to the ISO only group. Furthermore, the extract normalized the hematological values depressed by the ISO while significantly elevating the platelet count. UHPLC high-resolution orbitrap mass spectrometry analysis results revealed the presence of several antioxidants like vitamin C and related compounds, phenolic acids, flavonoid, fatty acids (oxylipins), and terpene derivatives. The results of this study indicated that Melicoccus bijugatus did display some cardio-protective effects in relation to myocardial injury.
Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Applications
Authors: Uscátegui Yomaira L. , Díaz Luis E. , Gómez-Tejedor José A. , Vallés-Lluch Ana , Vilariño-Feltrer Guillermo , Serrano María A. , Valero Manuel F.
Published: January 2019

Polyurethanes are widely used in the development of medical devices due to their biocompatibility, degradability, non-toxicity and chemical versatility. Polyurethanes were obtained from polyols derived from castor oil, and isophorone diisocyanate, with the incorporation of polycaprolactone-diol (15% w/w) and chitosan (3% w/w). The objective of this research was to evaluate the effect of the type of polyol and the incorporation of polycaprolactone-diol and chitosan on the mechanical and biological properties of the polyurethanes to identify the optimal ones for applications such as wound dressings or tissue engineering. Polyurethanes were characterized by stress-strain, contact angle by sessile drop method, thermogravimetric analysis, differential scanning calorimetry, water uptake and in vitro degradation by enzymatic processes. In vitro biological properties were evaluated by a 24 h cytotoxicity test using the colorimetric assay MTT and the LIVE/DEAD kit with cell line L-929 (mouse embryonic fibroblasts). In vitro evaluation of the possible inflammatory effect of polyurethane-based materials was evaluated by means of the expression of anti-inflammatory and proinflammatory cytokines expressed in a cellular model such as THP-1 cells by means of the MILLIPLEX® MAP kit. The modification of polyols derived from castor oil increases the mechanical properties of interest for a wide range of applications. The polyurethanes evaluated did not generate a cytotoxic effect on the evaluated cell line. The assessed polyurethanes are suggested as possible candidate biomaterials for wound dressings due to their improved mechanical properties and biocompatibility.
Anion-Binding-Induced Electrochemical Signal Transduction in Ferrocenylimidazolium: Combined Electrochemical Experimental and Theoretical Investigation
Authors: Weng Tan-Qing , Huang Yi-Fan , Xue Lou-Sha , Cheng Jie , Jin Shan , Liu Sheng-Hua , Wu De-Yin , Chen George Z.
Published: January 2019

Five ferrocene alkymethylimidazolium cations 1a–1d and 2 with different alkyl spacer lengths were reinvestigated using voltammetry and density functional theory (DFT) calculations. The voltammetric responses of ligand 2 toward various anions are described in detail. An interesting and unprecedented finding from both experimental and theoretical studies is that coupled electron and intramolecular anion (F−) transfer may be present in these molecules. In addition, it was also observed that, in these studied molecules, the electrostatic attraction interaction toward F− would effectively vanish beyond 1 nm, which was previously reported only for cations.
Functionalized Periodic Mesoporous Organosilicas: Tunable Hydrophobic Solid Acids for Biomass Conversion
Authors: Manayil Jinesh C. , Lee Adam F. , Wilson Karen
Published: January 2019

The catalytic deoxygenation of bio-based feedstocks to fuels and chemicals presents new challenges to the catalytic scientist, with many transformations either performed in or liberating water as a byproduct during reaction. The design of catalysts with tunable hydrophobicity to aid product and reactant adsorption or desorption, respectively, is vital for processes including (trans)esterification and condensation reactions employed in sustainable biodiesel production and bio-oil upgrading processes. Increasing surface hydrophobicity of catalyst materials offers a means to displace water from the catalyst active site, and minimizes potential deactivation or hydrolysis side reactions. Hybrid organic–inorganic porous solids offer exciting opportunities to tune surface polarity and hydrophobicity, as well as critical parameters in controlling adsorption, reactant activation, and product selectivity in liquid and vapor phase catalysis. Here, we review advances in the synthesis and application of sulfonic-acid-functionalized periodic mesoporous organosilicas (PMO) as tunable hydrophobic solid acid catalysts in reactions relevant to biorefining and biofuel production.
Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review
Authors: Loureiro Daniela R. P. , Soares José X. , Costa Joana C. , Magalhães Álvaro F. , Azevedo Carlos M. G. , Pinto Madalena M. M. , Afonso Carlos M. M.
Published: January 2019

Marine organisms represent almost half of total biodiversity and are a very important source of new bioactive substances. Within the varied biological activities found in marine products, their antimicrobial activity is one of the most relevant. Infectious diseases are responsible for high levels of morbidity and mortality and many antimicrobials lose their effectiveness with time due to the development of resistance. These facts justify the high importance of finding new, effective and safe anti-infective agents. Among the variety of biological activities of marine xanthone derivatives, one that must be highlighted is their anti-infective properties. In this work, a literature review of marine xanthones with anti-infective activity, namely antibacterial, antifungal, antiparasitic and antiviral, is presented. Their structures, biological activity, sources and the methods used for bioactivity evaluation are described. The xanthone derivatives are grouped in three sets: xanthones, hydroxanthones and glycosylated derivatives. Moreover, molecular descriptors, biophysico-chemical properties, and pharmacokinetic parameters were calculated, and the chemical space occupied by marine xanthone derivatives is recognized. The chemical space was compared with marketed drugs and framed accordingly to the drug-likeness concept in order to profile the pharmacokinetic of anti-infective marine xanthone derivatives.
Characterization of Humic Substances in the Soils of Ophiocordyceps sinensis Habitats in the Sejila Mountain, Tibet: Implication for the Food Source of Thitarodes Larvae
Authors: Li Yan , Guo Lian-Xian , Zhou Qian-Zhi , Chen Di , Liu Jin-Zhong , Xu Xiao-Ming , Wang Jiang-Hai
Published: January 2019

Humic substances in soil are considered to be an alternative food to the tender plant roots for Thitarodes larvae in the habitats of Ophiocordyceps sinensis in the Qinghai-Tibetan Plateau. However, there is no report involving the evaluation of their potential as a food source from the composition and structure of habitat soils. In this work, the composition and structure of humic substances in habitat soils from the Sejila Mountain, Tibet were characterized by diverse techniques for evaluating the nutritional value and possibility of humus as the food source for Thitarodes larvae. Fourier transform infrared spectroscopy revealed that humic acid may possess superior ability to provide the molecular segments for biosynthesizing lipids more than other humic fractions. Combining with the analysis of solid-state 13C nuclear magnetic resonance spectrum, the fractions of hydrophobic fulvic acid and hydrophilic fulvic acid are further considered as a potential food source for Thitarodes larvae. Overall, humic substances in habitat soils are rich in the molecular segments for biosynthesizing lipids and other important nutrients, which may provide the energy and material sources for maintaining the survival of Thitarodes larvae in the absence of tender plant roots, particularly in the annual cold winter. Combining with the evidence of physico-chemical parameters of habitat soils and stable carbon isotopic composition of major tender plant roots in the Sejila Mountain, the composition and structure of humic substances in habitat soils may provide a novel idea for the eco-friendly and semi-wild cultivation of Thitarodes larvae with low cost.
Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression
Authors: Zhang Bin , Zhang Xuelian , Zhang Chenyang , Shen Qiang , Sun Guibo , Sun Xiaobo
Published: January 2019

Diabetic nephropathy (DN) is a leading cause of end-stage renal failure, and no effective treatment is available. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng, and our previous studies showed the cardioprotective and neuroprotective effects of NGR1. However, its role in protecting against DN remains unexplored. Herein, we established an experimental model in db/db mice and HK-2 cells exposed to advanced glycation end products (AGEs). The in vivo investigation showed that NGR1 treatment increased serum lipid, β2-microglobulin, serum creatinine, and blood urea nitrogen levels of db/db mice. NGR1 attenuated histological abnormalities of kidney, as evidenced by reducing the glomerular volume and fibrosis in diabetic kidneys. In vitro, NGR1 treatment was further found to decrease AGE-induced mitochondria injury, limit an increase in reactive oxygen species (ROS), and reduce apoptosis in HK-2 cells. Mechanistically, NGR1 promoted nucleus nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions to eliminate ROS that induced apoptosis and transforming growth factor beta (TGF-β) signaling. In summary, these observations demonstrate that NGR1 exerts renoprotective effects against DN through the inhibition of apoptosis and renal fibrosis caused by oxidative stress. NGR1 might be a potential therapeutic medicine for the treatment of DN.
Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics
Authors: Vaara Martti
Published: January 2019

Polymyxins (polymyxin B (PMB) and polymyxin E (colistin)) are cyclic lipodecapeptide antibiotics, highly basic due to five free amino groups, and rapidly bactericidal against Gram-negative bacteria, such as the majority of Enterobacteriaceae as well as Acinetobacter baumannii and Pseudomonas aeruginosa. Their clinical use was abandoned in the 1960s because of nephrotoxicity and because better-tolerated drugs belonging to other antibiotic classes were introduced. Now, due to the global dissemination of extremely-drug resistant Gram-negative bacterial strains, polymyxins have resurged as the last-line drugs against those strains. Novel derivatives that are less toxic and/or more effective at tolerable doses are currently under preclinical development and their properties have recently been described in several extensive reviews. Other derivatives lack any direct bactericidal activity but damage the outermost permeability barrier, the outer membrane, of the target bacteria and make it more permeable to many other antibiotics. This review describes the properties of three thus far best-characterized “permeabilizer” derivatives, i.e., the classic permeabilizer polymyxin B nonapeptide (PMBN), NAB7061, and SPR741/NAB741, a compound that recently successfully passed the clinical phase 1. Also, a few other permeabilizer compounds are brought up.
A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia
Authors: Sun Hong-Jia-Qi , Xue Dong-Dong , Lu Bing-Zheng , Li Yuan , Sheng Long-Xiang , Zhu Zhu , Zhou Yu-Wei , Zhang Jing-Xia , Lin Gan-Jian , Lin Sui-Zhen , Yan Guang-Mei , Chen Yu-Pin , Yin Wei
Published: January 2019

Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of acute glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents in the clinical treatment of acute glaucoma. Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), a novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated the loss of retinal ganglion cells (RGCs) caused by acute intraocular hypertension (AIH). The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in BV2 microglia and RAW264.7 macrophages. Moreover, immunofluorescence and western blotting analysis revealed that sterone markedly abrogated the nuclear translocation and phosphorylation of nuclear factor-κB (NF-κB) p65 subunit. Furthermore, sterone significantly suppressed the inflammatory microglial activation and RGCs’ reduction caused by retinal ischemia/reperfusion (I/R) injury in a rat AIH model. These results suggest sterone may be a potential candidate in the treatment of acute glaucoma caused by microglial activation-mediated neuroinflammatory injury.
Functional Characteristics of Ultraviolet-Irradiated Tilapia Fish Skin Gelatin
Authors: Wu Cheng-Kuo , Tsai Jenn-Shou , Sung Wen-Chieh
Published: January 2019

Studies were undertaken to investigate the effects of ultraviolet (UV) irradiation on the gel strength, color, thermal properties, protein molecular masses, and functional groups of commercially available fish gelatin samples. Commercially available tilapia skin gelatin powder was used as the raw material to investigate the functional properties of fish skin gelatin powder treated with UV irradiation for different durations (0–6 h). The functional properties of fish gelatin and the optimum irradiation treatment conditions were determined through gel strength testing, color characterization, differential scanning calorimetry, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Fourier transform infrared (FTIR) spectroscopy, and Raman spectroscopy. UV irradiation treatment increased gel strength and thermal stability, and significantly degraded the macromolecules. FTIR and Raman spectroscopy data indicated that UV irradiation treatment did not significantly change the molecular structure of fish gelatin powder, but these methods could discriminate the molecular structure of gelatin from various sources. Irradiation for 2 h yielded the highest gel strength and melting peak temperature, and the lowest chromatic aberration.
Carotenoid-Derived Flavor Precursors from Averrhoa carambola Fresh Fruit
Authors: Jia Xuchao , Yang Dan , Yang Yue , Xie Haihui
Published: January 2019

The fruit of Averrhoa carambola L. (Oxalidaceae), commonly known as star fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of star fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in star fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound 11 was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7, 9, and 10) C13-norisoprenoid glucosides from the genus Averrhoa for the first time enriches the knowledge of carotenoid-derived flavor precursors in star fruit.
Sonochemical Degradation of Benzothiophene (BT) in Deionized Water, Natural Water and Sea Water
Authors: Al-Zaydi Khadijah M. , Petrier Christian , Mousally Sameera M. M. , Arab Sana T. , Refat Moamen S.
Published: January 2019

This paper deals with the sonochemical water treatment of polycyclic aromatic sulfur hydrocarbons (PASHs), one of the most common impurities found in waste water coming from petroleum industry. The best fit of the experimental data appears to be the kinetic parameters determined using the Michaelis-Mentonmodel in the concentrations range of the study. For the initial increase in the degradation rates, it is simply considered that the more the bulk concentration increases, the more the concentration in the interfacial region increases. This will be explained by Michaelis-Menton kinetics. The influence of organic compounds in the water matrix as a mixture with Benzothiophene (BT) was also evaluated. The results indicated that BT degradation is unaffected by the presence of bisphenol A (BPA). Finally, the results indicated that ultrasonic action is involved in oxidation rather than pyrolitic processing in the BT sonochemical degradation.
Metabolic Profiling of Nine Mentha Species and Prediction of Their Antioxidant Properties Using Chemometrics
Authors: Park Yun Ji , Baek Seung-A , Choi Yongsoo , Kim Jae Kwang , Park Sang Un
Published: January 2019

Mentha species are well recognized for their medicinal and aromatic properties. The comprehensive metabolite profiles of nine Mentha species have been determined. The extracts of these Mentha species were also screened for antioxidant and free radical scavenging activities. Forty-seven hydrophilic and seventeen lipophilic compounds were identified and quantified from the selected Mentha species. Also, eleven phenolic compounds, riboflavin and eight carotenoids were present, and their composition and content varied among the various Mentha species. The different Mentha species exhibited a range of antioxidant potencies. Horse mint especially exhibited the strongest antioxidant capacities (1,1-diphenyl-2-picryl-hydrazyl (DPPH), hydrogen peroxide, and reducing power assay) among the nine Mentha species. A difference between different samples from the same species was not observed by multivariate analysis. A high correlation between metabolites involved in closely linked biosynthetic pathways has been indicated. The projection to latent structure method, using the partial least squares (PLS) method, was applied to predict antioxidant capacities based on the metabolite profiles of Mentha leaves. According to the PLS analysis, several carotenoid contents, such as E-β-carotene, 9Z-β-carotene, 13Z-β-carotene and lutein, as well as phenolic compounds, showed a positive relationship in reducing the power of Mentha extracts. Horse mint is a good candidate because of its high antioxidant efficacy among the nine Mentha species included in the study.
Brown Seaweed Egregia menziesii’s Cytotoxic Activity against Brain Cancer Cell Lines
Authors: Olivares-Bañuelos Tatiana , Gutiérrez-Rodríguez Anllely G. , Méndez-Bellido Rodolfo , Tovar-Miranda Ricardo , Arroyo-Helguera Omar , Juárez-Portilla Claudia , Meza-Menchaca Thuluz , Aguilar-Rosas Luis E. , Hernández-Kelly Luisa C. R. , Ortega Arturo , Zepeda Rossana C.
Published: January 2019

Brown seaweeds contain bioactive compounds that show anti-tumorigenic effects. These characteristics have been repeatedly observed in the Lessoniaceae family. Egregia menziesii, a member of this family, is distributed in the North Pacific and its properties have been barely studied. We evaluated herein the cytotoxic and anti-proliferative activity of extracts of this seaweed, through toxicity assay in Artemia salina and lymphocytes, and MTT proliferation assay, in Bergmann glia cells, 3T3-L1 and brain cancer cell lines. E. menziesii’s extracts inhibited the spread of all the tested cell lines. The hexane extract showed the highest cytotoxic activity, while the methanol extract was moderately cytotoxic. Interestingly, seaweed extracts displayed a selective inhibition pattern. These results suggest that E. menziesii’s extracts might be good candidates for cancer prevention and the development of novel chemotherapies due to its highest cytotoxicity in transformed cells compare to glia primary cultures.
Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy
Authors: Bohr Adam , Nascimento Thais Leite , Harmankaya Necati , Weisser Johan Juhl , Wang Yingya , Grohganz Holger , Rades Thomas , Löbmann Korbinian
Published: January 2019

Many anti-cancer drugs are difficult to formulate into an oral dosage form because they are both poorly water-soluble and show poor permeability, the latter often as a result of being an intestinal efflux pump substrate. To obtain a more water-soluble formulation, one can take advantage of the higher solubility of the amorphous form of a given drug, whereas to increase permeability, one can make use of an efflux pump inhibitor. In this study, a combination of these two strategies was investigated using the co-amorphous approach, forming an amorphous mixture of two anti-cancer drugs, docetaxel (DTX) and bicalutamide (BIC). The efflux substrate, DTX, was combined with the efflux inhibitor, BIC, and prepared as a single phase co-amorphous mixture at a 1:1 molar ratio using vibrational ball milling. The co-amorphous formulation was tested in vitro and in vivo for its dissolution kinetics, supersaturation properties and pharmacokinetics in rats. The co-amorphous formulation showed a faster in vitro dissolution of both drugs compared to the control groups, but only DTX showed supersaturation (1.9 fold) compared to its equilibrium solubility. The findings for the co-amorphous formulation were in agreement with the pharmacokinetics data, showing a quicker onset in plasma concentration as well as a higher bioavailability for both DTX (15-fold) and BIC (3-fold) compared to the crystalline drugs alone. Furthermore, the co-amorphous formulation remained physically stable over 1.5 years at 4 °C under dry conditions.
Historiography and Remembrance: On Walter Benjamin’s Concept of Eingedenken
Authors: Bohn Charlotte Odilia
Published: January 2019

Engaging with Walter Benjamin’s concept of Eingedenken (remembrance), this article explores the pivotal role that remembrance plays in his attempt to develop a radically new vision of history, temporality, and human agency. Building on his essay “On Some Motifs in Baudelaire” and on his last written text, “Theses on the Philosophy of History”, it will trace how memory and historiography are brought together in a curious fusion of materialist and messianic thinking. Emerging from a critique of modernity and its ideology of progress that is cast as crisis—the practice of remembrance promises a ‘way out’. Many of Benjamin’s secular Marxist critics such as Max Horkheimer and Rolf Tiedemann, however, denied the political significance of Eingedenken—dismissing it as theological or banishing it to the realm of aesthetics. Rejecting this critique, I suggest that the radical ethical aspects of Eingedenken can be grasped only once the theological dimension is embraced in its own right and that it is in precisely this blend of materialist and messianic thought that revolutionary hope may be found.
In-Season Mapping of Irrigated Crops Using Landsat 8 and Sentinel-1 Time Series
Authors: Demarez Valérie , Helen Florian , Marais-Sicre Claire , Baup Frédéric
Published: January 2019

Numerous studies have reported the use of multi-spectral and multi-temporal remote sensing images to map irrigated crops. Such maps are useful for water management. The recent availability of optical and radar image time series such as the Sentinel data offers new opportunities to map land cover with high spatial and temporal resolutions. Early identification of irrigated crops is of major importance for irrigation scheduling, but the cloud coverage might significantly reduce the number of available optical images, making crop identification difficult. SAR image time series such as those provided by Sentinel-1 offer the possibility of improving early crop mapping. This paper studies the impact of the Sentinel-1 images when used jointly with optical imagery (Landsat8) and a digital elevation model of the Shuttle Radar Topography Mission (SRTM). The study site is located in a temperate zone (southwest France) with irrigated maize crops. The classifier used is the Random Forest. The combined use of the different data (radar, optical, and SRTM) improves the early classifications of the irrigated crops (k = 0.89) compared to classifications obtained using each type of data separately (k = 0.84). The use of the DEM is significant for the early stages but becomes useless once crops have reached their full development. In conclusion, compared to a “full optical” approach, the “combined” method is more robust over time as radar images permit cloudy conditions to be overcome.