bluuebunny/crossref_metadata_2025 huggingface dataset:
B. Wongar's Literary Work and Life from an Ethnological and Anthropological Perspective
Authors: Gorunović Gordana
Published: April 2020

This paper looks at the (auto)biography and literary work of an Australian writer of Serbian descent, B. Wongar/Sreten Božić, viewed from the perspective of ethnology and anthropology. His work is well known to local scholars of literary and cultural studies: for them, Wongar's complex and polysemous oeuvre has long since become a vibrant topic of interpretation and dialogue. An attempt is made here to show how and why this prolific, award-winning and world-renowned author has become a controversial phenomenon in Australian literature. Such a concise retrospective is needed so that readers outside the humanities can gain at least partial insight. The main aim is to highlight those topics in Wongar's fiction and documentary writing that are important from the standpoint of sociocultural anthropology and anthropology of literature: the characteristics of the migrant position and experiences of the dissident writer as a social actor, and the ethnographic-folkloric motivation of the writer's oeuvre.
The Application of Functional Theory: Indonesian Presidential Debate
Authors: Wahyuningsih Wahyuningsih , Nirmala Deli
Published: April 2020

Functional theory is a one of theories that are common used on the research of political debates in American campaign discourse. In the present article, Indonesian presidential debate is analyzed from the perspective of functional theory. The goal of this study is to analyze language function produced by candidates and to evaluate the applicability of functional theory in analyzing Indonesian presidential debate. The authors employ qualitative method in analyzing data. Supporting instruments in analyzing data were functional theory and political discourse analysis (PDA). PDA used in interpreting language function in political context. While, functional theory provides three functions, namely: attacks, defends, and acclaims. The finding shows that two different axioms are found. The first is the use of attack more than defense; it is line with the prediction of functional theory that has been tested in American political debate. Second, the use of acclaims less than attack, it differs in a way from the prediction of functional theory. Fundamentally, functional theory can be used as an instrument in analysis political debates in Indonesia even though the findings were not exactly consistence with the prediction. Thereby, the theory needs to be developed discursively.
Algunas consideraciones teórico-metodológicas para el estudio de la mujer obrera
Authors: Figueroa Ramírez Silvia Leticia , Avilés Muñoz Ana María
Published: April 2020

Dentro de las perspectivas que ofrece la investigación de la mujer, este estudio está orientado a conocer los efectos que produce en la unidad familiar la incorporación de la mujer a la industria de transformación local. Esto es, indagar de qué manera esta incorporación produce un debilitamiento en las relaciones de opresión que existen al interior de la unidad familiar, además de analizar el comportamiento de la mujer respecto a la responsabilidad que tiene en la reproducción de la fuerza de trabajo. Las proposiciones teóricas y metodológicas que se plantean para el estudio de la problemática de la mujer obrera resumen los esfuerzos por vincular, en un mismo análisis, la participación de ésta en ámbitos distintos como son el productivo y familiar. Pretender una conceptualización de la mujer partiendo de los espacios en que se involucra dentro de las relaciones es una labor ardua y complicada que debe continuarse.
Migración y fuerza de trabajo en los asentamientos humanos irregulares de la ciudad de Mexicali, B. C. 1940-1982
Authors: Fuentes Romero David F.
Published: April 2020

La región fronteriza del Norte en general es reflejo del tipo de relaciones entre México y Estados Unidos. En este documento se presenta información que permite constatar la importancia de los asentamientos humanos irregulares en el proceso de urbanización de la frontera, y en el conjunto de desplazamientos de población entre México y Estados Unidos. Además se detectó que dichos asentamientos juegan un papel destacado en el proceso migratorio en dos planos convergentes: a nivel internacional, entre México y los Estados Unidos; y a nivel regional, entre los municipios de Baja California y los del noroeste de Sonora. La investigación de este fenómeno migratorio aportó datos relevantes y sugirió cuestiones de gran importancia cuya respuesta es necesaria y por ende plantea la pertinencia de seguir avanzando en el estudio del tema.
Mujeres asalariadas: una realidad de explotación y opresión
Authors: Figueroa Ramírez Silvia Leticia , Avilés Muñoz Ana María
Published: April 2020

Este artículo destaca el análisis sociológico de los efectos que produce la industria de Mexicali en la familia de las obreras. Se analiza el tipo de relaciones laborales establecidas al interior de las unidades productivas de la industria de transformación mismas que se deduce son de explotación y de opresión. Sin embargo, la estabilidad laboral de la obrera permite establecer la existencia de un debilitamiento en las relaciones de opresión que existen al interior de las familias, al permitir a la mujer que trabaja tener mayor ingerencia en la toma de decisiones a partir de su incorporación a la industria. Finalmente, no obstante este trabajo significa un intento por analizar e incidir en el desarrollo teórico de la opresión, admitimos las limitaciones que una tarea de esta magnitud representa.
La frontera México-Estados Unidos: mexicanización e internacionalización
Authors: Revel Mouroz Jean
Published: April 2020

La presente investigación nos presenta una frontera de contacto directo que involucra a una superpotencia y a un país en vías de desarrollo. La frontera México-Estados Unidos es, en definitiva, una frontera antecedente porque su poblamiento es posterior a su delimitación jurídica. A lo largo de la línea fronteriza, la ósmosis económica de las ciudades en ambos países descansa, de manera general, en una interpenetración cultural. Si esta frontera es tan permeable con respecto a los productos y los hombres, es porque la línea de demarcación internacional no separa poblaciones realmente distintas a nivel regional. En base a los hechos aquí presentados, podemos deducir que comienza a estructurarse la cooperación deseada por las autoridades norteamericanas con respecto a un mercado común energético entre los Estados Unidos-Canadá-México.
Kutaneal Allodinisi Olan ve Olmayan Migren Hastalarında Ağrı Şiddeti, Uyku Kalitesi ve Psikolojik Durumun Karşılaştırılması
Authors: METE Oğuzhan , TOPRAK ÇELENAY Şeyda , ÇOBAN Özge , KARAHAN Nesrin
Published: April 2020

Amaç:
Çalışmanın amacı, kutaneal allodinisi olan ve olmayan migren hastalarında ağrı
şiddeti, uyku kalitesi ve psikolojik durumun karşılaştırılmasıydı.

Gereç ve Yöntemler: Çalışma olgu kontrol çalışma tipinde planlandı.
Çalışmaya otuz iki (32) migren hastası dahil edildi. Hastalar Allodini Semptom
Kontrol Listesine göre kutaneal allodinisi olan (16) ve olmayan (16) olmak
üzere iki gruba ayrıldı. Ağrı şiddeti Görsel Analog Skalası (GAS) ile, uyku
kalitesi Pittsburgh Uyku Kalitesi İndeksi (PUKİ) ile, psikolojik durum Hastane
Anksiyete (HAD-A) ve Depresyon Ölçeği (HAD-D) ile değerlendirildi.

Bulgular: Kuteneal allodini grubunda 6(%37.5) hasta ciddi, 5(%31.2) hasta orta,
5(%31.2) hasta hafif derecede kuteneal allodiniye sahipti. Kontrol grubunda
1(%6.2) hasta hafif, 10(%62.5) hasta orta, 5(%31.2) hasta ise ciddi şiddette
ağrıya sahipti. Kutaneal allodini grubunda 8(%50) hasta orta ve 8(%50) hasta
ciddi şiddette ağrıya sahipti. Kutaneal allodinisi olan bireylerin olmayanlara
göre GAS skorunun (p:0.005), HAD-A skorunun (p:0.034) ve PUKİ skorunun
(p:0.028) daha yüksek olduğu görüldü. Kutaneal allodinisi olan ve olmayan
bireylerin HAD-D skorunun (p:0.089) benzer olduğu saptandı.

Sonuç: Kuteneal allodinisi olan migren hastalarının kuteneal allodinisi
olmayan migren hastalarına göre ağrı şiddetinin ve anksiyete düzeyinin daha
yüksek olduğu ve uyku kalitesinin bozulduğu görüldü. Kuteneal allodinisi olan
migren hastalarında ağrı şiddetinin yanında uyku kalitesi ve psikolojik durumun
da değerlendirilmesi önemlidir ve tedavi planlanması açısından göz önünde
bulundurulmalıdır.
Perspektywy rozwoju filozofii tomistycznej na podstawie sytuacji w Polsce
Authors: Mikucki Kazimierz
Published: April 2020

W artykule poruszono problem perspektyw rozwoju, a tym samym przyszłości filozofii tomistycznej na podstawie sytuacji w Polsce. Otóż taką szansę widzi się dla tej filozofii w badaniach bardziej partykularnych, znajdujących się poza głównym obiektem zainteresowań metafizyki ogólnej. Każdorazowo przybierają one postać metafizyk szczegółowych i stosowanych. Pierwsza z nazw nawiązuje do zawężonego pola badań, druga natomiast jest uzasadniona korzystaniem z dorobku innych nauk filozoficznych, bardziej podstawowych, włącznie z metafizyką ogólną. Metafizyki tego rodzaju stanowią szeroko pojęte studium tego, co jest najbardziej fundamentalne nie dla bytu jako takiego, ale dla wszelkich podstawowych typów przedmiotów w sferze natury i kultury. Nie stanowią one jednak alternatywy dla metafizyki ogólnej, która bada rzeczywistość w wymiarze transcendentalnym, ponieważ korzystając z jej dorobku, zachowują z nią łączność oraz stanowią jej konieczne dopełnienie. Jako zaś typowe dyscypliny filozoficzne, dające możliwość rozwijania owych metafizyk, podano w artykule filozofię przyrody, antropologię filozoficzną oraz dwie formy filozofii ludzkiego działania, czyli religię i moralność. W ich przypadku wskazywano zarówno na tematy już podjęte przez wielu przedstawicieli myśli tomistycznej w Polsce oraz na te, jakie są możliwe do podjęcia. Realizacja tych form metafizyki odpowiada nie tylko strukturze rzeczywistości pluralistycznej i jednocześnie powiązanej ze sobą szeregiem zależności, ale też problemom aktualnym, nowym, wymagającym ujęcia gruntownego i całościowego, jakie stwarza dopiero perspektywa metafizyczna, rozpatrywana z pozycji filozofii tomistycznej.
Antithrombotic Treatment in Cardiomyopathies
Authors: Vogiatzi Georgia , Pantazis Antonios , Tousoulis Dimitris
Published: April 2020

:

Cardiomyopathies are a heterogeneous group of heart muscle diseases and important cause of heart
failure with reduced or preserved ejection fraction. Although there is an increasing body of evidence on the incidence,
pathophysiology, and natural history of heart failure (HF) in cardiomyopathies, certain aspects of the
therapeutic strategies remain unclear. More particularly, there is no consensus if to whether antithrombotic therapy
has a favorable risk: benefit ratio in reducing thromboembolic event rate in patients with cardiomyopathies
without suffering from primary valvular disease or atrial fibrillation. Although the observational data on increased
venous thromboembolic risk are supported by multiple pathophysiological mechanisms, the role of antithrombotic
therapy in these patients remains unclear. This review article provides an overview of epidemiologic, pathophysiologic,
clinical, and therapeutic data for the prevention of thromboembolism in heart failure due to cardiomyopathies.
Antiepileptogenic Effect of Retinoic Acid
Authors: Rosiles-Abonce Artemio , Rubio Carmen , Taddei Elisa , Rosiles Dulce , Rubio-Osornio Moisés
Published: April 2020

Retinoic acid, a metabolite of vitamin A, acts through either genomic or nongenomic
actions. The genomic action of retinoids exerts effects on gene transcription through interaction
with retinoid receptors such as retinoic acid receptors (RARα, β, and γ) and retinoid X receptors
(RXRα, β, and γ) that are primarily concentrated in the amygdala, pre-frontal cortex, and hippocampal
areas in the brain. In response to retinoid binding, RAR/RXR heterodimers undergo major
conformational changes and orchestrate the transcription of specific gene networks. Previous experimental
studies have reported that retinoic acid exerts an antiepileptogenic effect through diverse
mechanisms, including the modulation of gap junctions, neurotransmitters, long-term potentiation,
calcium channels and some genes. To our knowledge, there are no previous or current clinical trials
evaluating the use of retinoic acid for seizure control.
s-Proline Covalented Silicapropyl Modified Magnetic Nanoparticles: Synthesis, Characterization, Biological and Catalytic Activity for the Synthesis of thiazolidin-4- ones
Authors: Fekri Leila Zare
Published: April 2020

Background:

Thiazolidinoneones are important pharmaceutical compounds because of their
biological activities. Several methods for the synthesis of 4-thiazolidinones are widely reported in the
literature. The main synthetic routes to synthesize 1,3-thiazolidin-4-ones involve three components reaction
between amine, a carbonyl compound and thioglycolic acid.

Objective:

s-Proline covalented silicapropyl modified magnetic nanoparticles (Fe3O4@SiO2-Pr @s-proline)
were prepared. The antibacterial activity of synthesized nanoparticles against four bacterias was investigated
that showed that 30 Mg/L of synthesized nanoparticles is a suitable concentration for bacterial inhibitory.
Finally, the catalytic application of the synthesized s-Proline covalented silicapropyl modified magnetic
nanoparticles for the synthesis of thiazolidinones and pyrazolyl thiazolidinones under stirring in aqueous media
was evaluated. All of the synthesized organic compounds were characterized by mp, FT IR, 1H NMR, 13C
NMR and elemental analysis.

Materials and Methods:

A combination of aldehyde (1.0 mmol), thioglycolic acid (1.0 mmol), various amines
(1mmol) and 0.05 g Fe3O4@SiO2propyl@L-proline, were reacted at room temperature under stirring in 10 mL
water. After completion of the reaction, as indicated by TLC (4:1 hexane: ethylacetate), the reaction mixture
was filtered in the presence of an effective magnetic bar to separate the nanocatalyst. The nanocatalyst was
washed with a mixture of hot EtOH: H2O two times. The crude products were collected and recrystallized from
ethanol, if necessary.

Results and Discussion:

We present a novel avenue for the synthesis of thiazolidinones in the presence of
Fe3O4@SiO2-Pr @s-proline under solvent-free conditions.

Conclusion:

In conclusion, we have synthesized Fe3O4@SiO2-Pr@s-proline nanoparticles. Their biological
activity against 4 bacterias was investigated. It released that 30Mg/L is the suitable concentration of
synthesized nanoparticle for bacterial inhibitory. The catalytic efficiency of the catalyst was checked in the
multicomponent reaction of various aldehyde, thioglycolic acid and various amines under stirring. This
nanoparticle is a new organic-inorganic hybrid nanoparticle. The operational simplicity, the excellent yields of
products, ease of separation and recyclability of the magnetic catalyst, waste reduction and high selectivity are
the main advantages of this catalytic method. Furthermore, this new avenue is inexpensive and
environmentally benign.
Inter-Tissue and Intra-Tissue Co-Expression Networks in Human Metabolism: Morphological Evaluation of the Link Between Transcription Factors ERβ and NFAT in Morbid Obesity
Authors: Chasapi Athina , Balampanis Kostas , Kourea Eleni , Kalfaretzos Fotios , Lambadiari Vaia , Lambrou George I. , Melachrinou Maria , Sotiropoulou-Bonikou Georgia
Published: April 2020

Background:

Estrogen receptor β (ERβ) plays an important role in human metabolism and
some of its metabolic actions are mediated by a positive “cross-talk” with Nuclear Factor of Activated
T cells (NFAT) and the key metabolic transcriptional coregulator Transcriptional Intermediary Factor 2
(TIF2).

Introduction:

Our study is an “in situ” morphological evaluation of the communication between ERβ,
NFAT and TIF2 in morbid obesity. Potential correlations with clinicopathological parameters and with
the presence of diabetes and non-alcoholic fatty liver disease (NAFLD) were also explored. The aim of
the present study was to determine the role of ERβ and NFAT in the underlying pathophysiology of
obesity and related comorbidities. We have investigated the expression of specific proteins using immunochemistry
methodologies.

Methods:

Our population consists of 50 morbidly obese patients undergoing planned bariatric surgery,
during which biopsies were taken from visceral adipose tissue (VAT), subcutaneous adipose tissue
(SAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver and the differential
protein expression was evaluated by immunohistochemistry.

Results:

We demonstrated an extensive intra- and inter-tissue co-expression network, which confirms
the tissue-specific and integral role of each one of the investigated proteins in morbid obesity. Moreover,
a beneficial role of ERβ and NFATc1 against NAFLD is implicated, whereas the distinct roles of
TIF2 still remain an enigma.

Conclusions:

We believe that our findings will shed light on the complex underlying mechanisms and
that the investigated biomarkers could represent future targets for the prevention and therapy of obesity
and its comorbidities.
Challenges in Antenatal Corticosteroid Prescribing: A Retrospective Study
Authors: Armstrong-Kempter Shannon , Beech Lucinda , Melov Sarah J. , Kirby Adrienne , Nayyar Roshini
Published: April 2020

Background:

The discovery of the benefits of antenatal corticosteroids (ACS) for preterm
infants was one of the most significant developments in obstetric care. However, due to the
difficulty in predicting preterm delivery, optimal use of ACS, is challenging.

Objective:

To describe prescribing practices for antenatal corticosteroids (ACS) at a tertiary hospital
over five years to determine whether ACS were received at optimal timing; to determine patient
characteristics of women receiving ACS at optimal timing; to determine patient characteristics of
those who did not receive ACS as indicated and to examine the trend in ACS prescribing over the
study period.

Methods:

We performed a retrospective study of all deliveries from January 2011 to December
2015. The rates of ACS prescription for each group of women (preterm, late preterm, and term)
were recorded and analysed.

Results:

A total of 65% of women who delivered before 34 weeks’ gestation received ACS. Of
these women, 63% delivered within 7 days of receiving ACS. Women most likely to receive ACS
with optimal timing were primiparous (relative risk [RR], 1.25 [CI, 1.08-1.45]), or women diagnosed
with pre-eclampsia (RR, 1.34 [CI 1.10-1.63]), preterm premature rupture of membranes (RR,
1.33 [CI, 1.15-1.54]) or threatened preterm labour (RR, 1.42 [CI, 1.22-1.65]).

Conclusion:

A significant number of women and babies are exposed to ACS without commensurate
benefit, and a significant number who deliver preterm do not receive ACS. The percentage of
preterm and term infants receiving ACS should be determined to optimise service delivery.
Gastric Tract Infections Detection and Classification from Wireless Capsule Endoscopy using Computer Vision Techniques: A Review
Authors: Liaqat Amna , Khan Muhammad Attique , Sharif Muhammad , Mittal Mamta , Saba Tanzila , Manic K. Suresh , Al Attar Feras Nadhim Hasoon
Published: April 2020

Recent facts and figures published in various studies in the US show that approximately
27,510 new cases of gastric infections are diagnosed. Furthermore, it has also been reported that
the mortality rate is quite high in diagnosed cases. The early detection of these infections can save
precious human lives. As the manual process of these infections is time-consuming and expensive,
therefore automated Computer-Aided Diagnosis (CAD) systems are required which helps the endoscopy
specialists in their clinics. Generally, an automated method of gastric infection detections
using Wireless Capsule Endoscopy (WCE) is comprised of the following steps such as contrast preprocessing,
feature extraction, segmentation of infected regions, and classification into their relevant
categories. These steps consist of various challenges that reduce the detection and recognition
accuracy as well as increase the computation time. In this review, authors have focused on the importance
of WCE in medical imaging, the role of endoscopy for bleeding-related infections, and
the scope of endoscopy. Further, the general steps and highlighting the importance of each step
have been presented. A detailed discussion and future directions have been provided at the end.
Specific Heat Capacity Estimations for Biologically and Medicinally Important Compounds: Lidocaine Hydrochloride, Clove Oil and β-Piperine Using the DSC Technique
Authors: Gupta Gaurav , Shaikh Vasim , Kalas Sachin , Patil Kesharsingh
Published: April 2020

Aim:

To study the specific heat capacity for biologically and medicinally important
compounds, namely, lidocaine hydrochloride, clove oil and beta-Piperine using the
DSC technique.

Background:

One of the main problems in the science of medicine is the application of
drug molecules with limited solubility in water and in biofluids. Solubility is related to the
chemical potential of the solutes involved, which imparts free energy avenues, a necessary
requirement for equilibrium processes. The convincing solutions for solving this issue are
the utilization of ionic liquids as a drug. Lidocaine is the most widely utilized intraoral injected
dental anesthetic prior to performing painful medical procedures. Besides that, lidocaine
hydrochloride is a salt, having a melting point of 76°C (349 K) and behaves as an
ionic liquid after melting. Clove oil and β-piperine are very well-known naturally occurring
medicinal compounds having a broad spectrum of applications.

Objective:

To study the thermal gravimetry analysis behaviour for lidocaine hydrochloride,
clove oil and β-piperine. To compute specific heat capacity at constant pressure, as a function
of temperature for the studied systems.

Methods:

In the present communication, the studies of Thermal Gravimetry Analysis
(TGA) and Differential Scanning Calorimetry (DSC) for these compounds are described.

Results:

The data of heat flow have been utilized to obtain specific heat capacity (Cp) values
for lidocaine hydrochloride, clove oil and β-piperine over a temperature range between
75°C (348 K) and 155°C (428 K) based upon the methodology we have developed.

Conclusion:

LC•HCl behaves as an ionic liquid between 76 and 230°C (349 and 503 K).
Clove oil shows lower specific heat capacity values and is similar to other organic aromatic
compounds while piperine exhibits comparative high specific heat capacity values indicating
possibilities of intramolecular hydrogen bonding, which is generally not affected by
temperature.
Effect of Traditional Herbal Formulation on Experimental Models of Ulcerative Colitis
Authors: Boregowda Sateesha S. , Nithinkumar Karnati , Jayaramu Rajamma A. , Kalegowda Chandan , Avalakondareddy Govindareddy Y.
Published: April 2020

Aims:

Evaluation of the effectiveness of herbal formulation consisting of Morinda citrifolia
L, Artemisia annua L, Glycyrrhiza glabra L and Ocimum basilicum L, in treating ulcerative colitis.

Objectives:

Assessment of the effect of herbal formulation on the indomethacin-induced ulcerative
colitis based on serum lactate dehydrogenase (LDH) level, tissue myloperoxidase (MPO) activity
and colonic glutathione (GSH) content and macroscopic features. Determination of tissue ulcer
scores, tissue weight and tissue histopathological changes before and after treatment with herbal
formulation in disease-induced model.

Methods:

Herbal formulation from ancient literature was selected and evaluated for its effectiveness
against indomethacin-induced ulcerative colitis in rats. Mesalamine was used as a standard drug to
compare the effect of herbal formulation on ulcerative colitis. Quantification of serum LDH levels,
tissue MPO activity, colonic GSH levels, and the histopathological features of inflammatory and recovered
cells were used to establish the efficacy of the formulation.

Results:

Formulation treatment showed an appreciable increase in the serum GSH levels, and a decrease
in the tissue MPO activity and serum LDH levels. The results of ulcer score analysis and tissue
weight analysis of the formulation treated group were similar to the mesalamine treated group.
Histopathological studies revealed a decrease in oedema and reduced inflammation followed by the
formulation treatment.

Conclusion:

The study established the efficacy of polyherbal formulation in the treatment of ulcerative
colitis following sub-chronic administration. This study concludes that the polyherbal formulation
is effective as mesalamine in the treatment of ulcerative colitis.
Current and Future of Alzheimer's Therapy with the Best Approach
Authors: Singh Harminder , Chawla Viney , Bala Ritu , Dureja Harish
Published: April 2020

Introduction: In spite of the steady progress in the understanding of the etiopathogenesis of
Alzheimer's Disease (AD) for the last 50 years, exceptionally few long-standing drugs are, at present,
used for AD therapy. New interventions that either prevent, slow or stop the disease are urgently warranted
to overcome the growing AD burden. The aim of this narrative review is to summarize the currently
existing preclinical and clinical evidence regarding new drug development and biomarkers for
better understanding and focused management of AD. This article reviews the various potential and
existing targets /receptors with valid biomarkers applied in recent years to address the early-stage tasks
of the AD drug discovery process. A comprehensive literature search was conducted in the relevant
databases to identify studies published in recent years. In conclusion, the new approaches seem to aim
at examining the prospective neuroprotective activity of disease-modifying drugs in the presymptomatic
phases of AD, using biomarkers that detect progression of the disease before the growth of overt
dementia.
Mesoporous Silica Nanoparticles of Hydroxyurea: Potentially Active Therapeutic Agents
Authors: Nishchaya Kumar , Kushwaha Swatantra K.S. , Rai Awani K.
Published: April 2020

Background:

Present malignant cancer medicines have the advantage of magnetic nanoparticles
as delivery carriers to magnetically accumulate anticancer medication in malignant
growth tissue.

Aim:

In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent
and independent variables.

Methods:

In this study, microporous silica nanoparticles stacked with neoplastic medication were prepared
through emulsification followed by the solvent evaporation method. Prepared MSNs were optimized
for dependent and independent variables. Different formulations were prepared with varying
ratios of polymer, lipid and surfactant which affect drug release and kinetics of drug release pattern. The
obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release
kinetics study, and stability testing in order to investigate the nanoparticle characteristics.

Results:

The percentage drug entrapment of the drug for the formulations F1, F2, F3 was found
to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be
520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to
be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled
drug delivery for 6 hours.

Conclusion:

From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in
refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of
cancer due to its sustained release and less side effects.
Psychiatric Patients with a Serious Mental Illness and a Recent History of Violent Behavior: An Exploration of Developmental, Clinical, Cognitive, and Demographic Characteristics
Authors: Del Pozzo Jill , Cherneski Lindsay , Beck Saul J. , Lowe Sarah R. , Silverstein Steven M.
Published: April 2020

Background:

Epidemiologic studies have shown that persons suffering from psychotic disorders are at increased risk of violent behavior. Several factors have been shown to predict violent behavior among persons with psychosis. However, prior research is limited in that these factors have not been explored simultaneously within the same study.

Methods:

The current study, therefore, aimed to determine which demographic, clinical, cognitive, and developmental characteristics were associated with an increased likelihood of violence among patients diagnosed with a psychotic disorder and which combination of these best predicted a history of violence. Participants (n=53) completed measures of demographics, violence risk, psychotic and personality symptoms, trauma, psychopathy and cognitive functioning.

Results:

Bivariate relationships were conducted to compare the history of violent behavior between all variables. Additionally, a binary logistic regression was run predicting participants’ history of violence. Several demographic, cognitive, clinical, and developmental factors were associated with increased odds of having a history of violence. The overall correct classification rate for the model was 92.2%, with 87.5% of participants without a history of violence and 91.4% with a history of violence being correctly classified. The model included antisocial personality traits, poor behavioral controls, head injury, not accepting responsibility, lacking goals, prior supervision failures, and HCR-20 total score.

Conclusion:

The binary logistic regression model showed good accuracy in predicting a history of violence in persons with psychosis. These findings are consistent with prior research and can inform efforts at risk assessment and identification of treatment targets for people with a psychotic disorder who are at highest risk of violence.
Penggunaan Aplikasi Berbasis Android â€œFood Digital Mapâ€ untuk Panduan Konsumsi Makanan pada Remaja
Authors: Surmita Surmita , Widartika Widartika , Fitria Mona
Published: April 2020

Abstrak Asupan gizi pada masa remaja perlu mendapat perhatian agar sesuai dengan kebutuhan dan sebagian remaja kurang dari kebutuhan. Remaja memerlukan panduan dalam mengkonsumsi makananÂ  agar sesuai dengan kebutuhan. Penelitian ini menggunakan aplikasi berbasis android Â yang disebut â€œFood Digital Mapâ€ untuk membantu remaja dalam menghitung kebutuhan zat gizi dan asupan makanan yang dikonsumsi sehari-hari, sehingga remaja dapat mengkonsumsi zat gizi dalam jumlah seimbang.Â  Aplikasi Food Digital Map ini merupakan program yang dirancang untuk menghitung kebutuhan gizi dan asupan makanan yang diaplikasikan pada Android. Â Desain penelitian menggunakan metode eksperimental untuk melihat kesesuaian asupan zat gizi makro (karbohidrat, protein, lemak) pada remaja yang diberikan aplikasi Food Digital Map untuk digunakan sebagai panduan untuk mengukur kebutuhan dan asupan makan sehari-hari. Penelitian dilaksanakan di SMPN 14 dan SMPN 7 Bandung pada bulan Maret â€“ September 2017.Â  Hasil penelitian ini menunjukkanÂ  bahwa ada pengaruh pemberian Aplikasi Food Digital Map terhadap kesesuaian asupan dan kebutuhan zat gizi karbohidrat dan lemak (p< 0,05),Â  tetapi untuk asupan protein belum menunjukkan perbedaan yang signifikan ( p >0,05).Kata kunci: Food Digital Map, kesesuaian asupan dan kebutuhan, karbohidrat, protein, lemakÂ Abstract Nutrien intake in teenager must be balance with nutrient requirement. Nutrition intake in some teenagers is less than the requirement and others exceed the requirements.Â  Teenager need a guide to consumse foodÂ  to be equal with their nutrient requirement. This research used Food Digital Map software to help teenagers in calculating nutritional requirements and intake consumed daily. Food Digital Map are Software applied on Android Program that can use to calculate nutrient requirement and intake. Research design uses experimental to see the suitability of macro nutrient intake (carbohydrate, protein, fat) in teenager which given application of Food Digital Map to be used as a guide to measure nutritional requirement and Â Â intake. Place of study at SMPN 14 and SMPN 7 Bandung conducted in March - September 2017. The results of this study indicate that there are significant effect of used Food Digital Map Program for balance of nutritional intake and requirement for carbohydrate and fat (p< 0.05), but there are no significant differenceÂ  for protein intake (p> 0.05). Keywords: Food Digital Map, balance of intake and requirement,Â  carbohydrate, Â protein, fat
La influencia de la capacidad bélica sobre la soberanía nacional en las relaciones internacionales
Authors: Bermúdez Tapia Manuel Alexis
Published: April 2020

En el derecho internacional, la doctrina declara que los países son autónomos y soberanos, pero la realidad muestra que las relaciones entre países no suelen ser igualitarias. Hay una relación proporcional entre la capacidad bélica de un país y su influencia en las relaciones internacionales (diplomáticas, económicas, comerciales y políticas), en función de sus posibilidades de cooperación, subordinación, condicionamiento o enfrentamiento con otros países. Aquí se analizan las relaciones entre EE. UU., la Unión Europea, China y Rusia, así como el contexto latinoamericano. Mediante este análisis, se evidencia la influencia de la disposición de capacidad bélica de un país con miras a su política internacional en el contexto actual de la llamada diplomacia de las cañoneras.
¿Conciencia o identidad marítima? Un acercamiento a la relación del hombre con el mar
Authors: Rázuri Esteves Víctor Fernando
Published: April 2020

Este artículo aborda el tema de la relación del hombre con el mar en el caso de la sociedad peruana. Para ello, parte de la hipótesis de que esta relación no puede explicarse solamente desde el universo inteligible sino desde el mundo sensible, y analiza la correlación e influencia entre los conceptos de conciencia marítima (entendida como los conocimientos sobre el mar) e identidad marítima. Se aplicó un test de conocimientos y una escala tipo Likert a una muestra de 262 individuos. Al analizar los resultados, se encuentra una correlación positiva débil entre las dos variables y una influencia de un 12,2 % de los conocimientos sobre la identidad marítima. Con base en ello, se concluye que la identidad marítima explica más adecuadamente la relación del hombre con el mar.
Programa de reconversión laboral para la inserción del personal militar en retiro al sector civil
Authors: Puga Pomareda Juan José
Published: April 2020

Este artículo propone el diseño de un programa de reconversión laboral para que el personal militar en retiro de la Fuerza Aérea del Perú pueda reinsertarse al mercado de trabajo mediante la adaptación de sus competencias. Esto se hace mediante un enfoque cuantitativo y cualitativo, para medir la percepción del personal militar y las brechas existentes entre los perfiles del mercado laboral con los del ámbito militar. Para validar el diseño propuesto, se hizo un análisis de adaptabilidad, practicabilidad y aceptabilidad. Los resultados muestran la viabilidad de la propuesta y permiten ver que el 95 % de la muestra está de acuerdo con la implementación de programa de reconversión laboral. Así, esta propuesta puede influir directa y significativamente en la inserción del personal militar en retiro al mercado laboral peruano.
Los derechos de las mujeres víctimas del conflicto armado colombiano
Authors: Atencio Gómez Miriam Sofía
Published: April 2020

Este artículo tiene como objetivo, mediante una metodología descriptiva y cualitativa, identificar los derechos que tienen las mujeres víctimas de graves violaciones a los derechos humanos e infracciones al DIH perpetrados por actores armados irregulares con ocasión del conflicto armado interno colombiano. En tal sentido, se identifican en primer lugar los instrumentos internacionales y regionales que amparan a las mujeres; luego se consideran las normas nacionales de protección y garantía con respecto a los derechos. Posteriormente se analiza la situación de las mujeres colombianas víctimas, para luego describir los derechos de las víctimas, especialmente el derecho a la verdad, el derecho a la justicia y el derecho a la reparación, frente a los cuales el Estado colombiano aún tiene el deber de avanzar.
DENEYİMSEL PAZARLAMANIN TÜKETİCİ SATIN ALMA NİYETİ ÜZERİNE ETKİSİ: SAKARYA İLİ ÖRNEĞİ
Authors: SERHATERİ Ayhan , KURŞUN Fatih Güray
Published: April 2020

Amaç: Bu çalışmada deneyimsel pazarlamanın tüketici üzerindeki etkisi ve tüketici satın alma niyeti üzerindeki etkilerinin detaylı olarak açıklanması amaçlanmaktadır. Bu amaç doğrultusunda demografik faktörlerin deneyimsel boyutlara etkisini araştırmak ve deneyimsel pazarlamanın tüketicinin satın alma niyetini ne oranda etkilediğini tespit edilmesi hedeflenmiştir.Yöntem: Bu araştırmada Sakarya şehrinde market alışverişi yapan 400 kişiye anket uygulanmıştır. Anket sonuçları değerlendirilirken, Faktör Analizi, T Testi, Regresyon analizi ve Tek yönlü ANOVA testi uygulanmıştır. Demografik faktörlerin deneyimsel pazarlamaya etkisi ve deneyimsel pazarlamanın boyutlarının satın alma niyetine etkisi olup olmadığı incelenmiştir. Bulgular: Yapılan regresyon analizi sonucunda deneyimsel pazarlamanın boyutlarının tüketici satın alma niyetine etkisi olduğunu desteklenmiştir. Sonuç: Deneyimsel pazarlama boyutları tüketici satın alma niyetini pozitif yönde etkilemektedir.
VENÖZ TROMBOEMBOLİZMİN MALİYETLERİ VE EKONOMİK YÜKÜNÜN BELİRLENMESİNE İLİŞKİN SİSTEMATİK BİR DERLEME: FARMAEKONOMİK ÖNLEYİCİ BİR TEDAVİ OLARAK DMAH
Authors: KOCA Gülsüm Şeyma , ÇELİK Yusuf
Published: April 2020

Amaç: Bu araştırmada; Venöz Thromboembolizm, Pulmoner Embolizm, Derin Ven Thrombozunun tedavi maliyetlerinin belirlenmesi ve önleyici antikoagülan bir tedavi olan Düşük Molekül Ağırlıklı Heparin bir sağlık sigortasına veya hastaneye getirdiği ekonomik yükün tespit edilmesi amaçlanmıştır.Yöntem: Araştırmada ekonomik yükün tespiti için raporlanan makalelerin seçiminde sistematik derleme analizinden yararlanılmıştır. Dahil etme ve dışlama kriterlerine göre VTE, DVT, PE veya her ikisinin tedavisindeki doğrudan/dolaylı maliyetlerini ele alan ve bu komplikasyonların önlenmesinde kullanılan antikagülan tedavi maliyetlerini raporlayan tüm çalışmalar ele alınmıştır. Seçilen araştırmalar prospektif gözlemsel araştırmalar veya retrospektif araştırmalar, sistematik derleme araştırmalarıdır. Buna göre, toplam 35 araştırma incelenmiştir.Bulgular: Araştırmada, VTE için yıllık ortalama maliyet; minimum 503,322$, yeniden yatış olması durumunda maksimum 86.744$’lara kadar ulaşmıştır. ABD’de VTE maliyetleri (3000$-9500$) arasında bir değişim göstermekte iken, Avrupa’da (2.215$-4.030$) arasında olduğu görülmüştür. PE için yıllık ortalama maliyetlerin ise minimum 3.758$ ile maksimum 23.050$ arasında değiştiği, tekrarlı yatış olması durumunda ya da olayın birincil teşhis mi yoksa ikincil mi teşhis olması durumuna göre 13.018$ ile 16.644$ arasında maliyetin bir değişim gösterdiği görülmüştür. DVT için yıllık ortalama maliyetler (3.740,48$-26.292$) arası, toplam maliyetler ise minimum 1.095$ ile 10.758$ arasında bir maliyete neden olmakta, DVT’e eşlik eden PE olması durumunda ise yıllık toplam maliyetler (12.200$-30.404$) dır. DMAH’ın satın alma maliyeti 7 günlük doz üzerinden yapılan hesaplamalarda ortalama olarak (127$-211,7$) bulgulanmıştır.Sonuç: Bu araştırmadan elde edilen sonuçlar, VTE atakları ve tekrarlayan VTE'nin önlenmesi için uygulanan mevcut antigüakogülan tedavi seçeneklerinin karşılaştırılması açısından önemli olup, hastanelere ve sağlık sigortalarının bütçesine etkisinin tahmininde önemli bir fayda sağlayacaktır.
Responsiveness of Arab Women in Israel to Genetic Screening Tests Prior to/during Pregnancy
Authors: Gabarin Sara
Published: April 2020

Hereditary morbidity is a severe health problem in the Muslim Arab society in Israel. There are populations where the prevalence of the Mendelian type hereditary diseases is 1 in 4 or 5 residents (Al Aqeel, 2007). One of the reasons for this is the high prevalence of relation marriage, which as of 2009 accounted for 24% of all marriages (Na’amnih et al., 2015). Despite this high prevalence, responsiveness to performing hereditary screening tests in Israel is very low among Arab women. For example, in performing Fragile X screening tests, only 9.1% of Arab women reported having performed the test, compared to 52% of Jewish women (Romano-Zlicha & Shochat, 2011).
The Relationship between Motivation and Academic Performance in Chiropractic Students
Authors: Zhang Niu , He Xiaohua
Published: April 2020

This study aimed to investigate the relationship between motivation and academic performance in chiropractic students. This was a cross-sectional study. Three hundred and sixty-two students were recruited from the 1st and 3rd quarters during the 2017-2018 academic year. Out of 362 students, 305 completed the Inventory of School Motivation (ISM). Total scores from the 1st quarter General Anatomy course and the 3rd quarter Immunology/Endocrinology course were used to measure the 1st quarter and 3rd quarter academic performance, respectively. The mean total motivation score for all students was 28.40 ± 3.79 (mean ± SD). There was no signi?cant difference in total motivation score between students in the two quarters (p > .05). The mean of the 1st quarter praise scores was statistically significantly higher than those of the 3rd quarter (p < .05). The means of three motivation subscale scores for females were signi?cantly higher than that for males (task, effort, and praise, p < .05) while the mean competition score for males was signi?cantly higher than that for females (p < .01). The linear analysis demonstrated a weak but statistically significant correlation of task (r = .11, p < .05) and effort (r = .13, p < .05) with academic performance indicating that task and effort were minor predictors of academic outcome (p < .05).There was a weak, but statistically significant positive correlation between the three motivation subscales and academic performance. Female students scored significantly higher on three motivation subscales while males scored higher on one.
„LAŽNE VESTI” ILI DEZINFORMACIJE: (SAMO)REGULATORNI OKVIR I IZAZOVI U PRAKSI
Authors: Surculija Milojevic Jelena , Kulic Milica
Published: April 2020

„Lažne vesti”, ili ispravnije – dezinformacije i kao fenomen i kao termini jesu u hiperinflaciji. Ni u praksi, ni u medijskoj teoriji, a ni u medijskom pravu ne postoji jasan konsenzus šta sve spada pod „lažne vesti”, odnosno koji je to „neprijatelj borbe”. U međuvremenu, „lažne vesti”, naročito dezinformacije na internetu, počele su da odlučuju o onima koji odlučuju, da utiču na izborne odluke i kreiraju društvenu i političku stvarnost. Za diseminaciju „lažnih vesti” optužuju se institucionalni izvori, politički lideri i mediji, međutim, one svoje mesto pronalaze i na društvenim mrežama gde se nemerljivom brzinom šire. Istraživanje Oksford internet instituta pokazuje da je, tokom mid-term izbora u SAD-u u novembru 2018. godine, broj linkova ka „lažnim vestima” prvi put premašio broj linkova ka profesionalnim medijima.
Ovaj rad teži da doprinese postojećoj debati o pokušaju jasnog definisanja pojma dezinformacija, posmatrajući ga kako sa stanovišta medijske teorije, tako i sa stanovišta medijske etike, medijskog prava i internet prava. Rad analizira postojeće pojmovno određivanje pojma dezinformacija od strane međunarodnih organizacija, kao i često nepostojanje jasnog određenja prema ovom pojmu od strane pojedinačnih država. Predmet analize su i dometi samoregulacije, kroz samoregulatorne mehanizme strukovnih, pre svega novinarskih udruženja, ali i takozvane „pseudoregulacije” u kojoj kompanije koje posluju nadnacionalno, kao što su Fejsbuk (Facebook), Gugl (Google), Tviter (Twitter), Mozila (Mozzila), počinju same sebe da regulišu.
GENOCIDNA NAMERA – ESENCIJA ZLOČINA GENOCIDA – problem interpretacije elemenata genocidne namere u postupku utvrđivanja zločina genocida –
Authors: Palevic Milan , Rapajic Milan
Published: April 2020

Predmet ovog rada je genocidna namera – konstitutivni element i distinktivno obeležje zločina genocida. Pregledom i analizom pravnog režima genocida i ključnih stavova doktrine o datoj problematici, u radu se ukazuje na specifičnost sadržinskih elemenata genocidne namere, njihovu konceptualnu međuzavisnost i teškoće u definisanju i primeni jasnih, opšteprihvatljivih standarda i kriterijuma u postupku utvrđivanja postojanja različitih pojavnih oblika genocidne namere i samog zločina genocida. Neka tradicionalna rešenja sučeljena su sa novim koncepcijskim pristupima i dostupnom sudskom praksom, pre svega praksom dva ad hoc tribunala, kao i stavovima i mišljenjima sudija Međunarodnog suda pravde, datih povodom tri predmeta genocida koji su izneti pred njim. Iz tog „intelektualnog kvazikonflikta” autori su izveli opšti kritički komentar – zaključak o postojanju raskoraka, nekonzistentnosti i neke vrste konfuzije u odnosu normativnog, doktrinarnog i praktično primenljivog u materiji genocida, što vodi dezavuisanju, trivijalizaciji i političkoj zloupotrebi koncepta prevencije i kažnjavanja ovog zločina, kako su oni zamišljeni u, manje više opravdano kritikovanoj, Konvenciji iz 1948. godine. U radu se ne obrađuje „nacionalna, verska, rasna i etnička grupa” kao element genocidne namere, iz razloga što je jedan od autora već objavio rad na tu temu.
THE CROWDING-OUT EFFECT OF FISCAL POLICY ON CAPITAL INFLOWS IN NIGERIA
Authors: Babalola Abdurrauf Idowu , Onikosi-Alliyu Saidat Oluwatoyin
Published: April 2020

The study investigated the effect of fiscal policy on crowding out capital inflows in Nigeria using annual data between 1970 and 2011 by using the foreign direct investment (FDI) as proxy to capital inflows represent the dependent variable, budget deficit (BD), foreign borrowing (FL) and domestic borrowing (DL) as proxies to fiscal policy are placed as explanatory variables. Cointegration and ECM technique were employed. Our finding showed that in both the short and long run, BD does not crowd out but rather crowd in FDI. In the short run, DL averagely has significant positive impact on FDI.  However, in the long run, DL has significant negative impact on FDI. More so, in both short run and long run period, FL has significant negative impact on FDI, therefore, FL crowds out FDI. The speed of adjustment back to equilibrium showed that the explanatory variables have capacity to adjust FDI significantly. The study recommends that the government could try to be aware of the implication of its fiscal policy in running a budget deficit and making proper decision in sourcing for funds to finance the deficit. Foreign borrowing is less expensive in financing budget deficit, so if the government must borrow, it should give preference to this source. Generally, the government should reduce deficit because of the implications inherent in it.
MACROECONOMIC DIVERGENCES AND ASYMMETRIC RESPONSES WITHIN THE EURO ZONE
Authors: Beker Pucar Emilija , Glavaški Olgica
Published: April 2020

The paper deals with the nominal and real divergences within the Euro-zone (EZ) as a background for asymmetric European Central Bank’s (ECB’s) monetary transmission. In order to shed more light into these issues, the descriptive analysis of key nominal and real indicators confirms the core-periphery dichotomy within original EZ12 members, as well as the specific position of the emerging EZ19 members. Monetary (interest rate) transmission is explored via estimated Vector Autoregression (VAR) model for the representatives of the core (Germany, France, Belgium), as well as the periphery (Portugal, Spain and Greece), in the period 1999Q1-2018Q4. Observing the transmission of ECB’s interest rate (the shock) to gross domestic product (GDP) growth (the response), the results of variance decompositions and impulse responses indicate that interest rate channel works countercyclical in general. However, while stabilizing (countercyclical) effect is evident for the core (especially Germany), it is almost absent in the case of Greece. The conclusions highlight the vulnerability of the EZ in the sense of heterogeneous membership and, accordingly, asymmetric response to ECB’s monetary impulse. Our findings support the arguments of numerous research papers in emphasizing core-periphery dualism, German dominance hypothesis, and “one size fits some” monetary policy.