bluuebunny/crossref_metadata_2025 huggingface dataset:
JOGOS INDÍGENAS E A LEI 11.645/2008: POSSIBILIDADES PARA UM CURRÍCULO INTERCULTURAL
Authors: Moraes da Silva Inayara , Rabelo Jairzinho , Dorigon Juli Cristina
Published: October 2024

A proposta que move este estudo baseia-se em uma pesquisa bibliográfica que visa analisar como as atividades realizadas nos Jogos Indígenas podem ser utilizadas no currículo, considerando as memórias e a cultura dos povos originários, correlacionando-as às exigências da Lei 11.645/2008. Pensar os Jogos Indígenas nessa perspectiva é uma resposta que a escola precisa dar às inúmeras culturas presentes na sociedade, nos papéis que os professores podem exercer no desenvolvimento do currículo, especificamente quando se quer atender a diversidade e ainda nas potencialidades da educação intercultural no sentido da renovação de um currículo que concretize o princípio de escola para todos. Buscaremos um diálogo com os principais autores sobre interculturalidade, identidade, conceitos sobre o currículo inter e multicultural, e sua conexão com a diversidade, utilizando os Jogos Indígenas para analisar formas diversas de conhecimentos construídos nesses eventos, de maneira que seja possível aproximá-los das práticas docentes e propor a atividade intercultural na escola, em conformidade com a legislação. Nessa direção, Grando, Xavante e Campos (2015) trazem em seu trabalho um importante estudo sobre jogos e brincadeiras indígenas presentes na memória de adultos e idosos de 18 etnias indígenas.  Por seu turno, Cuyabano (2010) amplia a discussão ao contextualizar as relações históricas entre os povos originários e a sociedade não indígena, a partir do diálogo com as experiências vivenciadas nos jogos e a literatura atual.  Na mesma direção, o autor Silva (2014) em seu livro “Identidade e diferença: a perspectiva dos Estudos culturais” apresenta a importância do conceito de identidade e as relações entre cultura, identidade e diferença. Por seu turno, direção Brighenti (2022) apresenta a relação entre a Lei 11.445, educação intercultural que pode ser vivenciada na escola. Em outra direção, os autores Dorrico (2021) e Delmondez e Pulino (2014), discutem a relação entre educação indígena e educação escolar indígena, entre outros autores com importante contribuição sobre o currículo intercultural neste estudo.  Nessa perspectiva, situamos este trabalho, que busca uma educação democrática, justa e plural, com especial relevância no momento atual marcado por perspectivas conservadoras e reacionárias, orientado pela perspectiva decolonial e sua inter-relação com a educação intercultural crítica.
Museu Virtual na Amazônia
Authors: Nascimento Cleane , Machado Ananda , Maroti Paulo Sérgio
Published: October 2024

A presente proposta propõe discutir o potencial da construção de um Museu Virtual com Artes de Mulheres Indígenas em Roraima e seu uso pedagógico, visando contribuir na implementação da Lei nº 11.645. A partir do uso das Tecnologias da Informação e Comunicação (TIC), recurso que será disponibilizado gratuitamente na web, propiciaremos a divulgação e a democratização das artes e das histórias de mulheres indígenas em Roraima. E assim o discente, na interação com o Museu, será um sujeito ativo, reflexivo e crítico. A metodologia utilizada consiste na pesquisa qualitativa, com resultados que permitem a vivência de experiências inovadoras na proposição de um espaço de protagonismo das mulheres indígenas e dos discentes no processo de ensino/aprendizagem.
Entraves e perspectivas na implementação da Lei 10.639/2003 na Amazônia acreana após duas décadas de sua aprovação 2003 a 2023
Authors: Bastos de Albuquerque Ângela Maria , Fernandes da Silva Jorge
Published: October 2024

O artigo analisa os avanços e retrocessos na aplicabilidade da Lei 10.639/2003 nas formações de professores para educação básica na Amazônia acreana. Resgatamos os princípios das Resoluções CNE/CP nº 1, de 17 de junho de 2004 e, da Resolução CNE/CP nº 2, de 1º de julho de 2015 que regulamentam a institucionalização do ensino da história e cultura afro-brasileira nos cursos de formações de professores nas IES. Consubstanciamos esse conjunto de leis sob a ótica teórica de Almeida (2019) e Araújo (2021) no contexto de outras bibliografias produzidas em nível local e nacional. Compreendemos a importância dessas legislações nas vivências e experiências de pessoas negras ao tempo que reconhecemos os esforços de docentes comprometidos(as) com a temática porque a mesma não foi plenamente institucionalizada nas IES do Acre.
Enhancing anatomy comprehension through competency-specific formative assessments: A study on the effectiveness of pre and post lecture multiple-choice questions in CBME
Authors: Rajasekhar SSSN  , Nagarajan Sujithaa
Published: October 2024

Modern medical education was required to include clear, tailored and regular formative assessments, especially for Millennials. Competency-Based Medical Education (CBME) emphasized the objective assessment of anatomical competencies. Question-answer and viva-voce tests were considered subjective and resource-intensive. This research was conducted to examine how competency-specific formative assessments using multiple-choice questions and photos before and after competency-based medical lectures improved anatomy comprehension.

: The research involved 150 first-year MBBS students who were enrolled in online anatomy courses. Competency-specific, picture-based, clinical scenario-based and multiple-choice pre-questionnaires were distributed. The questions were reviewed and attempted by students before attending the theory classes. Lecture classes were conducted according to the curriculum and competencies of the National Medical Council. After the lecture, the questions and answers were reviewed and a feedback questionnaire was administered. The feedback survey included Likert scale responses and open-ended questions to gauge students' opinions on the teaching and learning methodology.

: It was observed that the method was effective, stimulating curiosity, motivation and engagement. Participants expressed that the approach facilitated memorization, imparted clinical knowledge and reinforced theory. Clinical scenario-based multiple-choice questions were found to enhance memory, spark interest and improve understanding of anatomy's clinical relevance. Students believed that this method would benefit them in university exams. Overall, 89.7% of participants found the methods highly satisfactory, 50% satisfactory and 10.3% unsatisfactory.

: Competency-specific formative assessments using multiple-choice questions and photos before and after lectures were found to improve anatomy knowledge. The strategy was found to promote engagement, memory and clinical understanding, reinforcing anatomical concepts. The results of this study suggested that competency-specific formative assessments added value to the current CBME-based medical education by increasing learning and practical application.
Anomalous bipartite parietal bone variant mimicking fracture in a human skull-A case report
Authors: Subbramaniam Mouna , Gowda Ayush
Published: October 2024

The proper growth of the skull depends on the cranial sutures. There have been references in the literature to the occurrence of bipartite, tripartite and quadripartite parietal bones. Regular ante mortem and postmortem investigations may reveal these fracture-mimicking anatomical variations, which might change the path of the diagnosis and medico legal certification. Therefore, having sufficient knowledge about the occurrence of these abnormal suture variations will improve both postmortem and ante mortem diagnosis. In this case study, the genesis and clinical relevance of a unilateral bipartite parietal bone discovered in a museum specimen are discussed.
Guía para promover la igualdad de género en las empresas de América Latina y el Caribe
Authors: Avella Analia Marina , Hakspiel Julia , Villanueva María Teresa
Published: October 2024

Esta guía tiene como objetivo orientar al sector empresarial en el diseño e implementación de medidas que promuevan la igualdad de oportunidades entre hombres y mujeres en los entornos laborales. Está dirigida a organizaciones de todos los tamaños y sectores interesadas en construir espacios de trabajo más equitativos e inclusivos. Provee evidencia, recursos de apoyo y herramientas prácticas para facilitar la adopción de políticas específicas. Además, ofrece hojas de ruta claras para abordar dimensiones clave, como el liderazgo femenino, la equidad salarial, la corresponsabilidad en los cuidados y las cadenas de valor inclusivas, con recomendaciones flexibles y adaptables a los distintos contextos y necesidades de cada empresa. También presenta estudios de caso regionales e internacionales que muestran cómo diversas organizaciones han implementado estas estrategias y los resultados obtenidos.
Влияние параметров механоактивации на формирование сверхпроводящей фазы в YBCO композите
Authors: Төлендіұлы С. , Совет Ә. , Садыков М. , Фоменко С.М. , Акишев А. , Бекджанова М.Т. , Камунур К. , Абишева А.К. , Рахым Н.Т.
Published: October 2024

верхпроводниковые материалы на основе купратов, относящиеся к высокотемпературным сверхпроводникам, характеризуются неустойчивостью формирования фазового состава в зависимости от метода их получения. Настоящая работа посвящена синтезу сверхпроводника YBCO с применением предварительной механообработки исходных компонентов шихты, в процессе которой за счет высокой дисперсности и повышения концентрации образования наночастиц из исходных компонентов шихты повышается их реакционная способность и вследствие этого увеличивается формирование полезной сверхпроводящей фазы в конечном композите. Применение предварительной механоактивации (МА) инициирует процесс диспергации и активации компонентов шихты. Исследуемые образцы в условиях МА обрабатывались в течение 10, 20, 30, 40 и 50 минут. Из полученных механоактивированных порошков далее методом твердофазного горения синтезированы композиты, исследование которых показало, что они отличаются по свойствам и структуре в зависимости от длительности процесса МА. Исследование микроструктуры и фазового состава показало, что оптимальные свойства проявили образцы с 30-ти минутной механоактивацией. Структура композита характеризуется мелкозернистой субстанцией с практическим отсутствием пор и высокой концентрированной плотностью, однородным фазовым составом YBCO, что позволило получить сверхпроводник с высокой критической температурой перехода в сверхпроводящее состояние при 80 К.
Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides
Authors: Nurkenov O.A. , Fazylov S.D. , Nurmaganbetov Zh.S. , Seilkhanov T.M. , Mendibayeva A.Zh. , Kabieva S.K. , Satbaeva E.M.
Published: October 2024

The article presents the results of a study of the amination reaction of nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in the search and creation of drugs for respiratory and circulatory stimulants. The study was conducted to search for new biologically active compounds with anti-inflammatory activity. The synthesis of new aminoamides was carried out by the interaction of nicotinic acid with molecules of morpholine, cytisine, and adamantane in anhydrous ethanol. As a result of the conducted studies, new amides of nicotinic acid with high yields (90.7–93.1%) were obtained. The structures of the new compounds were determined using NMR 1H and 13C spectroscopy methods, as well as data from two-dimensional spectra of COSY (1H-1H), HMQC (1H-13C), HMBC (1H-13C) and mass spectrometry. The results of an experimental study of the anti-inflammatory activity of synthesized new amides are presented. The anti-inflammatory effect of nicotinic acid N-adamantylamide was established, other new amides were ineffective compared with ibuprofen (p2 < 0.05).
Improvement of the QoS for WiMAX Service Classes
Authors: Jakimoski Kire , Janevski Toni
Published: October 2024

Mobile users connected to the WiMAX technology can use five different service classes according to their different needs. In this paper we propose priority based uplink scheduling scheme for IEEE 802.16 standard that improves the QoS performances of the WiMAX service classes, especially when the number of connections gets higher. Essential QoS parameters like throughput, delay and jitter have been calculated using the ns-2 simulation tool and changing the number of the ertPS connections. Obtained results prove that our proposed uplink scheduling algorithm gives better results compared with so far known uplink scheduling mechanism.
The Investigation of Gas Ejector Performance using CFD Modelling
Authors: Aldas Kemal , Şen Faruk , Ozkul Iskender
Published: October 2024

Computational fluid Dynamics (CFD) has been widely used to simulate the experimental studies, which cost a lot of time and need to be repeated many times, in different fields of the industry with sufficient accuracy results. Therewithal, the energy conservation and controlled use of energy is very important for the more clean and habitable world. Therefore, refrigerant gases used in cooling systems should not affect global warming and damage to the ozone layer. Regarding that, in this study the ejector performance was mapped in Computational Fluid Dynamics (CFD) software using R600a (isobutene) refrigerant gas that the hydrocarbon-based, non-ODP (Ozone Depletion Potential) and has less effect of GWP (Global Warming Potential).
The Analysis of Labour Productivity in East European Countries
Authors: Tanning Toivo , Tanning Lembo
Published: October 2024

- The purpose of this paper is to analyze the productivity or efficiency of the new European Union (EU) states, with emphasis on Estonia; and to compare them on the EU level. Industry, construction, trade and transport in Estonia have been viewed separately. Labour market problems in Eastern European countries have become more and more important. When the EU labour markets opened, some EU countries were forced to face the problem of partial workforce drain to richer countries with higher wages. In addition, on the one hand, East European countries have quite high unemployment rates, and on the other, many vacant jobs – there is a lack of qualified workforce. Low salaries, among other reasons, force many people to go to work in rich countries, where wages are several times higher. A number of proposals to increase labour productivity for both workers and entrepreneurs have been listed in the summary.
Cardiometabolic Risk Calculation in the Assessment of Cardiometabolic Risk Profiles
Authors: Smiljenic Dragana , Ostojic Milica
Published: October 2024

Numerous factors, together labelled as cardiometabolic risk (CMR), increase chances for developing cardiometabolic diseases. CMR estimation has a crucial role in the early prevention and enables the prompt treatment to prevent disease progression and complications. For this purpose several calculators and scoring systems were created, all based on similar, but not the same, input variables. CMR calculators are usually based on various statistical procedures and are result of previously conducted studies. Artificial neural network (ANN) is a method of artificial intelligence that has been recently applied for assessment of CMR in an easy, non-invasive and cheap way.
An ANFIS-Based Approach for Predicting the Surface Roughness of Cold Work Tool Steel in WEDM
Authors: Aldas Kemal , Özkul Iskender , Akkurt Adnan
Published: October 2024

Wire electrical discharge machining known as non-traditional machining processes, has a significant role in the manufacturing industry. Conductive materials, which can have intricate and complex forms, can be obtained regardless of hardness. In this study, the surface roughness of Sleipner cold work steel is evaluated under various machining process parameters in the WEDM process. In the experiments the feed rate, current, and pulse on time are used as independent variables. In order to predict the surface roughness, an Adaptive Neuro-Fuzzy Inference system was applied based on experimental data.
The Competitive Edge of a Manufacturing Enterprise: Multicriteria Evaluating
Authors: Zvirblis Algis , Buracas Antanas , Ignotas Anicetas
Published: October 2024

The paper deals with the multicriteria evaluation of competitive edge of an enterprise on the basis of primary criteria complex. We investigated the possibilities to apply the MCDM methods, such as SAW, COPRAS, and, as a result, the comprehensive set of primary evaluation criteria having different impact significance was created. The general index of relative competitive edge of an enterprise based on presented evaluation models (adequate to applied SAW method) has been determined. The suggested technique was applied to the case evaluation of some Lithuanian windows manufacturing enterprises.
The Turnover of Transportation Companies in the European Countries of the Former Eastern Bloc before and after the Economic Crisis
Authors: Tanning Toivo , Tanning Lembo
Published: October 2024

The purpose of this paper is to analyze the key indicators of transportation companies, with emphasis on turnover of enterprises, in the Central and Eastern Europe (CEE), or of new European Union (EU) states before and after the economic crisis, and to compare them on the EU level. We will look at how the economic crisis has affected transportation companies of various sizes and the number of persons employed. We will analyze also changes in the labour market, turnover, added value, profit and labour productivity according to the size classes of companies. Changes in labour productivity will be viewed based on turnover and gross added value per employed person. The work efficiency of these companies will be compared to other EU states, incl. the Baltic States. Based on this and previous publications, we will offer a number of generalized recommendations.
Comparison of Programming Languages ASP (Commercial) and PHP (Open Source) while Designing Small/Typical Websites
Authors: Arnautovic Mehmed , Bundalo Zlatko
Published: October 2024

ASP and PHP are programming languages mostly used for creating websites. Unlike static HTML websites, ASP and PHP are used for creating dynamic websites and they enable interaction and exchange of information among users. User’s data is saved in the database. ASP (Active Server Pages) is a type of program that works with Microsoft and IIS (Internet Information Server). On the other hand, PHP or Hypertext Preprocessor works with Linux or Unix. PHP programs can run in Windows, Solaris, Unix and Linux, while ASP can run only on Windows based platforms. Here is represented a comparison between programming languages PHP and ASP, and results are from multiple websites.
The Assessment of Students’ Satisfaction in the South-Eastern European Countries: An Alternative Approach for Evaluating the Quality of Higher Education
Authors: Nikoloski Dimitar , Mancheski Gjorgji , Angeleski Marjan , Kushi Evis
Published: October 2024

In this paper we assess the student satisfaction as an alternative approach for evaluating the quality of higher education. For this purpose we have carried out a survey on representative samples of students in two universities: “St. KlimentOhridski” (Macedonia) and “AleksanderXhuvani” (Albania). According to our empirical analysis, study programs generally meet the students’ expectations and they are more satisfied with the obtained theoretical knowledge rather than the gathered practical skills. Furthermore, they are generally pessimistic or uncertain about their future labour market perspectives which can be considered as a reason for pronounced intention to continue education after graduation.
Drying Kinetics of Sunflower Seeds using Pulsed UHF Energy Intake
Authors: Mircea Bernic , Marcel Raducan , Eugeniu Ciobanu
Published: October 2024

In this paper the drying kinetics of sunflower seeds using pulsed UHF energy intake are given. It is shown and argued that the application of pulsed internal heat source made possible the reduction of heat treatment period by 17%, and of specific energy consumption by 21.8%.
Customer Satisfaction Index – as a Base for Strategic Marketing Management
Authors: Ilieska Karolina
Published: October 2024

Customer satisfaction index -CSI results provide: an economic indicator of the quality of economic output; calculation of the net present value of their company’s customer base as an asset over time; information for strategic business applications; a predictor of consumer spending & corporate earnings. In this paper the focus of research is customer satisfaction index as a base for new strategic marketing management. For this purpose I have carried out a survey on representative samples of Macedonian passenger and research services quality and customer satisfaction index (CSI) in the macedonian passenger transport.
Development Perspectives of Investment Funds in Republic of Macedonia
Authors: Odzaklieska Dragica , Sotiroski Kosta , Todorovska Marinela
Published: October 2024

This paper will discuss the importance of investment funds for the expansion of investment alternatives in the capital market in the Republic of Macedonia, as well as their role in collecting funds from small investors who often do not possess sufficient knowledge and financial resources to achieve satisfactory degree of diversification of their individual portfolio. It will also give a review of perspectives, measures and recommendations to encourage the development of these financial institutions in our country.
Application of Skype API to Control Working Time
Authors: Vasilev Julian
Published: October 2024

The purpose of this article is to present an innovative approach to monitor and control working time. A special software program is developed by Delphi implementing Skype API functions. This article shows three different approaches to control working time using the Skype_API program. It automatically detects when an employee goes to his working place and when he leaves work. Moreover it can check periodically weather an employee is at work. The proposed ideas are written for the first time. They may be applied easily in many enterprises with very low costs.
Rapid Prediction of Moisture and Ash Content in Sungkai Leaves Herbal Tea (Peronema canescens Jack.) using NIR Spectroscopy
Authors: Andasuryani Andasuryani , Ifmalinda
Published: October 2024

It is imperative to measure the chemical composition of Sungkai leaf herbal tea in order to produce high-quality goods that promote human health. The moisture and ash content of Sungkai leaf herbal tea are critical parameters for assessing the quality of herbal tea. This study aimed to evaluate an NIR spectroscopy method for quickly determining the moisture and ash content of Sungkai leaf herbal tea. Sungkai leaf herbal tea has a moisture content between 3.93% and 7.59%, and an ash content between 3.94% and 5.51%. We developed a calibration model using partial least squares (PLS) with several pretreatment methods. We split the data into calibration and prediction sets and performed an internal random cross-validation. A PLS calibration model with Rp2 = 0.86, a root means square error of prediction (RMSEP) of 0.30 (%), and a residual predictive deviation (RPD) of 2.76, performed exceptionally well at predicting the moisture content when the standard normal variate (SNV) pre-treatment was applied to the NIR spectra. The Savitzky-Golay derivative (a 9-point smoothing window, second-order polynomial, dg2) pre-treatment method also generated the best PLS calibration model for ash content determination, with Rp2 = 0.70, RMSEP = 0.16 (%), and RPD = 1.86. NIR spectroscopy can quickly determine the moisture and ash content of Sungkai leaf herbal tea, as suggested by these findings.
Beyond Design: Examining the Implementation of Gender-Responsive Social Protection in Ethiopia
Authors: Kuss Maria Klara , af Hällström Sofia
Published: October 2024

Recent years have witnessed increased global attention and investment in inclusive and gender-responsive social protection programming in low- and middle-income countries. While high-level design commitments are important and welcome, in practice, they may not guarantee protection from vulnerabilities and a reduction in gender inequality. Programme implementation presents a critical, yet often underestimated, challenge. This article offers insights into the reality of implementing the gender provisions of Ethiopia’s Productive Safety Net Programme. Drawing on qualitative data from rural Ethiopia, it shows that the implementation of the gender provisions has generated implementation gaps and inconsistencies. The findings highlight the need to move beyond commitments on paper and allocate greater resources and attention to the implementation of gender-responsive social protection.
Student Engagement, Community of Inquiry, and Transactional Distance in Online Learning Environments: A Stepwise Multiple Linear Regression Analysis
Authors: Gökoğlu Seyfullah , Karaoğlan Yılmaz Fatma Gizem , Yılmaz Ramazan
Published: October 2024

This study explored the complex dynamics of student engagement, community of inquiry, and transactional distance in online learning environments. The study analyzed 1,281 participants’ responses to identify the factors contributing to online learning outcomes. The research highlighted the crucial role that transactional distance and community of inquiry play in shaping students’ behavioral engagement and provided insight into their significant impact on participants’ learning experience. Through a stepwise multiple linear regression analysis, the research uncovered the complex relationships among these variables, thereby providing valuable insights for educators and institutions aiming to enhance the online learning experience. The results have significant implications for educational practitioners and policymakers, including practical strategies to increase student engagement and foster a lively community of inquiry in online learning environments. Ultimately, this research is a valuable resource for all those involved in online education, to help them understand the key factors that contribute to successful online learning experiences.
From defence catchment area to hinterland: Bordeaux during the Hundred Years War
Authors: Lavaud Sandrine
Published: October 2024

Buoyed by a favourable political and economic tide, Bordeaux asserted itself in the late Middle Ages as the capital of Anglo-Gascon Aquitaine. To impart substance to its dreams of city-statehood, it intensified the construction of its hinterland and tightened its hold on it. This heightened dominance, which took on multiple forms, brought areas under its tutelage. Historians examining modes of polarisation and the resulting formation of spaces may have recourse to a number of indicators of the process of territorialisation. In an earlier study I was able to gauge the relevance of grape-growing and wine-making as an approach to Bordeaux’s centrality. The present study takes up this same perspective of appraising Bordeaux’s hinterland but adopts a fresh indicator – the defensive criterion. The main corpus of sources, Bordeaux’s municipal debates in the early decades of the 15th century, paints a picture of the defensive catchment area in a major phase of extension at a time when hostilities in the Hundred Years War were intensifying in Guyenne and the chief town had to ensure the defence of the duchy and at the same time become a strongpoint. In their war effort, the jurats of Bordeaux had all at once to assemble armed forces, conduct military operations, multiply negotiations and diplomatic initiatives and consolidate alliances. All these actions were recounted in the municipal registers and contributed to the construction of a defensive system. Reconstructing the components and spatial dynamics of this system and mapping it is a way for historians to measure the territorialisation it gave rise to and its part in the construction of Bordeaux’s hinterland.
Mentoring Experiences of New Online Teachers: Voices of Graduate and Early Career Instructors
Authors: Garcia Heather , Dello Stritto Mary Ellen
Published: October 2024

This research study explores the mentoring experiences of graduate student and early career instructors who teach online courses at a mid-size public university in the United States. As members of a centralized online learning unit that works with instructors teaching online courses across a range of disciplines, we sought to better understand the mentoring experiences of instructors who are new to online teaching. Using a narrative methodology, we analyzed interview transcripts and found that graduate student and early career instructors have variable access to mentoring, experience different sources of mentoring, and engage with multiple types of mentoring. We found that graduate student instructors have more access to different sources and types of mentoring than early career instructors, but that both groups desired additional mentoring opportunities. Participants recognized the value of mentoring experiences as part of their overall professional development. We conclude with suggested actions for units looking to support mentoring for online instructors.
Machine learning descriptors for crystal materials: applications in Ni-rich layered cathode and lithium anode materials for high-energy-density lithium batteries
Authors: Zhang Ruiqi , Rong Fangchao , Lai Genming , Wu Guangyin , Ye Yaokun , Zheng Jiaxin
Published: October 2024

Lithium batteries have revolutionized energy storage with their high energy density and long lifespan, but challenges such as energy density limitations, safety, and cost still need to be addressed. Crystalline materials, including Ni-rich cathodes and lithium anodes, play pivotal roles in the performance of high-energy-density lithium batteries. Understanding the micro-scale behavior and degradation mechanisms of these materials is crucial for improving macro-scale battery performance. Simulation methods, particularly machine learning (ML) techniques, have become indispensable tools in elucidating these intricate processes because of great efficiency and acceptable accuracy. ML methods depend on descriptors, which bridge the gap between crystal structures and input matrices of models. These descriptors encode essential atomic-level details in crystal structures, enabling predictions of material properties and behaviors relevant to lithium batteries. This paper reviews and discusses the diverse array of descriptors employed in the simulation of crystalline materials for lithium batteries with high energy density. Case studies highlight the effectiveness of different descriptors in simulating cathode behaviors such as Li/Ni disordering, screening of stable LiNi0.8Co0.1Mn0.1O2 (NMC811) configurations, and lithium deposition behaviors at the anode interface. The discussed descriptors can also be applied to other crystalline cathode, anode, and electrolyte materials in lithium batteries and advance the development of lithium batteries with superior energy density.
Designing a Multi-Epitope Vaccine Candidate to MERS-CoV: An in silico Approach
Authors: Majeed Muhammad Nouman , Iqbal Azhar , Murtaza Nayab , Herrera-Zúñiga Leonardo David , Siddique Shoaib  , Raza Mohsin  , Hussain Momina , Sajid Muhammad
Published: October 2024

Background. Middle East Respiratory Syndrome Coronavirus (MERS-CoV), associated with severe respiratory illness, originates from the Middle East region. The virus is transmitted from animals to humans, with the dromedary camel serving as a significant reservoir. The virus's high fatality rate has spurred research into vaccine development and therapeutics.
Objective. This study aimed to employ an in silico approach to design a potential vaccine candidate against MERS-CoV, focusing on the M protein as an antigen.
Methods. The FASTA sequence of M protein was used to predict B cell and major histocompatibility complex class I and class II epitopes. The best epitopes were selected from these predicted epitopes. The vaccine candi­date's construct consisted of epitopes, linkers, and a tag. The sequence of the vaccine candidate's construct, consisting of 390 amino acids, was back-translated, optimized, and then inserted into a plasmid for cloning and expression using SnapGene. The 3D structure of the vaccine candidate is docked with TLR-4 receptor. Molecular dynamics simulation was run for this docked complex using GROMACS gmx, version 2021.4.
Results. Through computational modeling and analysis, we developed a novel vaccine candidate with pro­mising structural and functional properties. Our results suggest that the designed vaccine candidate has the potential to induce a robust immune response.
Conclusions. This in silico approach presents a promising MERS-CoV vaccine candidate designed to trigger both humoral and cellular immune responses. This candidate holds the potential to provide broad-spectrum protection against MERS-CoV.
OCORRÊNCIA DE CANDIDÍASE BUCAL E FATORES ASSOCIADOS EM INDIVÍDUOS COM HIV/AIDS HOSPITALIZADOS EM UM HOSPITAL UNIVERSITÁRIO DO TOCANTINS
Authors: E Silva Pereira Karina , Neres Soares Suzana , Rocha de Melo Sara , França de Freitas Thaíse Maria
Published: October 2024

INTRODUÇÃO: Infecções bucais, como a candidíase, são comuns em pacientes imunocomprometidos com HIV/AIDS, pois o vírus destrói algumas células encarregadas de garantir a defesa do organismo, tornando a pessoa vulnerável a infecções e doenças oportunistas. OBJETIVO: Verificar a ocorrência de candidíase bucal em indivíduos hospitalizados no Hospital de Doenças Tropicais do Tocantins (HDT-UFT), bem como a investigação de fatores clínicos e epidemiológicos associados à candidíase. MÉTODO: Trata-se de estudo retrospectivo, observacional, descritivo e documental com abordagem quantitativa. Para a coleta de dados foi realizado um levantamento dos prontuários dos pacientes que constituíram o universo de estudo utilizando-se um formulário semiestruturado. Após a coleta dos dados em prontuários de indivíduos com HIV/AIDS internados no hospital no período de 2017 a 2019 foi realizada a tabulação e análise dos mesmos. RESULTADOS: Constatou-se que, do total da amostra, 45 (54,87%) eram do sexo masculino e 36 (43,9%) do sexo feminino. A manifestação bucal de candidíase foi detectada em 28,04% casos. Todos os indivíduos que tiveram candidíase bucal fizeram uso antifúngicos, com remissão da infecção em 34,78% casos, sendo que em 56,52% dos prontuários não tinham informações quanto a remissão das lesões. Dentre os indivíduos que tiveram o diagnóstico por candidíase bucal 73,91% apresentavam contagem de linfócitos T CD4 abaixo de 200 células/mm³ e 60,86% tinham carga viral acima de 10000 cópias/ml, indicando uma correlação entre as variáveis. CONCLUSÃO: A ocorrência de candidíase bucal foi verificada predominantemente nas idades entre 48 e 64 anos, pardos, do sexo masculino e com pouco grau de instrução, tendo o nível de escolaridade variando entre ensino fundamental e médio.
Levantamento das síndromes Pós-Covid em uma unidade de saúde da região norte de Palmas - TO / DATA SURVEY OF POST-COVID SYNDROMES IN A HEALTH UNIT FROM THE NORTH REGION OF PALMAS – TO
Authors: REIS DE OLIVEIRA CAMAROLLI ALICE KELLY , Malheiros Alves Marta Maria , DE SOUSA RÊIS MÁRLLON
Published: October 2024

Introdução: A Covid-19 pode trazer consequências em longo prazo, uma vez que afeta diversos órgãos, resultando em processo de recuperação mais prolongado e por vezes, complexo. A síndrome pós-Covid-19 ou Covid Longo, como também pode ser chamada, nada mais é do que os sintomas persistentes ou disfunção após o período agudo da infecção pelo SARS-CoV2.
Objetivo: Analisar os sintomas persistentes após a infecção pela Covid-19 em pacientes assistidos por uma Unidade de Saúde da região norte de Palmas-TO.
Métodos: Estudo quantitativo, transversal, de objetivo descritivo, onde foram analisadas as respostas dos participantes, que foram obtidas através da aplicação de questionário físico ou online.
Resultados: As comorbidades pré-relatadas estão diretamente correlacionadas com o surgimento da síndrome pós-Covid nessa população. Todos os sintomas foram relatados após o período agudo ou ainda persistiram desde a fase aguda até quatro semanas após.
Conclusões: Apesar das limitações, nossos resultados demonstram que há um risco considerável de sequelas na população. Destacamos ainda o quão amplo são as manifestações da síndrome pós-Covid, seja ela após infecção aguda leve, moderada ou grave.
Palavras-chave:                                                  
Infecções por Coronavírus; Epidemiologia; Vírus da SARS; Pandemias; Complicações.
 
 
ABSTRACT
Introduction: The Covid-19 infection can have long-term consequences, since it affects several organs, resulting in a longer and complex recovery process. Post-Covid-19 syndrome or Long Covid, as it has been called, is nothing more than persistent symptoms or resulting dysfunction after the acute period of SARS-CoV2 infection.
Objective: Analyze persistent symptoms after infection with Covid-19 in patients assisted by a Health Unit from the northern region of Palmas-TO.
Methods: Quantitative and cross-sectional study, with a descriptive objective, where the answer of the participants were analyzed. The answers were obtained through the application of a physical or online questionnaire.
Results: Pre-reported comorbidities are directly correlated with the onset of post-Covid syndrome in this population. All symptoms were reported after the acute period or still persisted from the acute phase up to four weeks later.
Conclusion: Despite the limitations, our results demonstrate that there is a considerable risk of sequelae in the population. We also highlight how broad the manifestations of post-Covid syndrome are, be it after mild, moderate or severe acute infection.
Keywords:
Coronavirus Infections; Epidemiology; SARS Virus; Pandemics; Complications.
Building Tennessee’s Workforce: An Assessment of Credential Completion at Tennessee Colleges of Applied Technology
Authors: Kamer Jacob Andrew
Published: October 2024

Tennessee Colleges of Applied Technology (TCATs) are the primary providers of public postsecondary Career and Technical Education (CTE) opportunities in the state. The purpose of this study was to determine which student demographic and enrollment characteristics significantly correlated with the completion of a postsecondary certificate or diploma at a TCAT. Using a state administrative dataset and employing multilevel modeling techniques, this study found students who enrolled on a full-time schedule, who had a prior postsecondary education background, and who received the state’s need-based grant had significantly higher odds of credential completion. Students who had below a high school education, students who were classified as nontraditional based on gender and program of study, and Students of Color had significantly lower odds.
Conocimientos sobre hipomineralización del incisivo molar en odontopediatras de Lima metropolitana
Authors:   , Patiño Bautista Katiuska Evelyn
Published: October 2024

Introducción: Los odontopediatras son los profesionales idóneos en brindar atención odontológica al niño y adolescente con hipomineralización del incisivo molar (HIM), exigiendo del especialista tener conocimientos correctos del abordaje clínico que eviten afectar su calidad de vida. Objetivo: Determinar el nivel de conocimientos sobre HIM en odontopediatras de Lima Metropolitana. Material y métodos: Estudio observacional transversal en muestra de 166 odontopediatras (91,6 % mujeres, edad media 34 años) que respondieron un cuestionario virtual valido (V de Aiken=97,5 %) y confiable (KR=0,72) de 16 preguntas de conocimientos sobre HIM con cuatro dimensiones (etiología, diagnostico, clínica y tratamiento). El puntaje se convirtió a escala vigesimal y se categorizó en bajo, medio y alto. Otras variables demográficas incluidas fueron edad, sexo, años de egreso, grado de estudios, cantidad de atenciones diarias y sector laboral. Las pruebas inferenciales incluyeron correlación de Spearman, U de Mann-Whitney, Kruskall-Wallis, Exacta de Fisher y Chi-cuadrado a un p valor de 0,05. Resultados: El puntaje de conocimientos fue de 14,91 ± 2,8 puntos, estando la mayoría distribuidos en un nivel medio (44,6 %) y alto (44 %). Los % de respuestas correctas fueron mayores en la dimensión clínica (79,5 % a 95,2 %) y tratamiento (72,3 % a 83,1 %). Ni el puntaje ni el nivel de conocimientos sobre HIM se asociaron a las variables demográficas (p≥0,05). Conclusión: La mayoría de los odontopediatras presentaron un nivel de conocimientos de HIM aceptables, sobre todo, relacionados a la clínica y tratamiento, pero no a la demografía de los participantes.
Ethical and regulatory issues and factors around 3D printing in Orthopaedic surgery: a scoping review Protocol
Authors: Akpa-Inyang Francis , Rocher Antoine , Marais Leonard
Published: October 2024

Background: The use of three-dimensional (3D) printing technology in orthopaedic surgery has become increasingly prevalent, offering numerous benefits such as improved surgical planning, personalized implants, and enhanced patient outcomes. However, along with the rapid adoption of this technology, ethical and regulatory considerations have emerged. This scoping review protocol aims to systematically evaluate the existing literature on ethical and regulatory issues related to 3D printing in orthopaedic surgery.
Method and Analysis:The protocol follows a rigorous methodology, including a comprehensive search of electronic databases such as PubMed/MEDLINE, EBSCOhost (academic search complete, CINAHL with full text) Scopus, Google Scholar, and web of science, using predefined search terms and inclusion criteria. The search will include studies published from 2011 to 2023 to ensure the most up-to-date information is captured. The scoping review will employ a systematic approach to study selection, data extraction, and synthesis of findings. The identified studies will undergo critical appraisal to assess their quality and relevance to the research question. Data synthesis will involve thematic analysis and the generation of a comprehensive overview of the ethical and regulatory issues associated with 3D printing in orthopaedic surgery.
Discussion: The findings of this scoping review will contribute to the existing body of knowledge by providing a comprehensive and systematic evaluation of the ethical and regulatory landscape surrounding 3D printing in orthopaedic surgery. It will identify gaps in the literature, highlight areas of concern, and offer recommendations for future research and policy development.
Ultimately, the aim of this scoping review is to provide healthcare professionals, researchers, and policymakers with a comprehensive understanding of the ethical and regulatory challenges associated with the use of 3D printing in orthopaedic surgery. This knowledge will facilitate the development of guidelines and best practices to ensure the responsible and ethical integration of 3D printing technology in orthopaedic surgical practice.
Counseling individuals with pathogenic loss-of-function variants in FLNA – learning points from a cross-sectional cohort study.
Authors: RIJCKMANS Ellen , De Strooper Lars P. , Keymolen Kathelijn , Rosenblum Jessica , Loeys Bart , Meuwissen Marije , Jansen Anna C. , Stouffs Katrien
Published: October 2024

BACKGROUND Filamin A (FLNA) is an actin-binding protein involved in cytoskeleton organization and cell migration. Gain-of-function (GOF) variants in FLNA are associated with oto-palato-digital spectrum disorders (OPDSD). Loss-of-function (LOF) variants give rise to a wide variety of symptoms with periventricular nodular heterotopia (PVNH) and epilepsy as the most common features. FLNA deficiency manifests as a multisystemic disorder with abnormalities of connective tissue and involvement of the cardiovascular, pulmonary, gastrointestinal and hematological system. Affected individuals need a multidisciplinary follow-up, but guidelines are lacking. Here, we present findings from a monocentric cross-sectional cohort study as a basis for improving clinical practices and surveillance for individuals with pathogenic FLNA variants.RESULTS The FLNA-cohort consisted of 24 index patients with a pathogenic (class 5) LOF variant in FLNA. In the cohort, 23 patients exhibited clinical features of PVNH, while one individual manifested congenital pulmonary airway malformation (CPAM). The incidence of clinical features such as epilepsy (84%) and cardiovascular involvement (56%) are consistent with previously published cohorts. Systematic multidisciplinary follow-up, particularly regular cardiological screening, was lacking in a significant number of individuals. Additionally, lesser-known symptoms such as constipation and thrombocytopenia were underreported, highlighting the need for comprehensive phenotypic assessment in FLNA deficiency.CONCLUSION The incidence of clinical features in this tertiary cohort aligns with existing literature. The absence of uniform and multidisciplinary guidelines hampers effective surveillance and management. Implementation of regular cardiological screening and increased awareness of less overt symptoms could enhance medical outcomes for individuals with pathogenic FLNA variants.
Immunohistochemical Analysis of Mastocyte Inflammation: A Comparative Study in COPD Associated with Tobacco Smoking and Wood Smoke Exposure
Authors: Robles-Hernández Robinson , Rivera Rosa M. , Páramo-Pérez Marcos , Quiroz-Camacho Dulce Mariana , Centeno-Saenz Gustavo I. , Bedolla-Tinoco Alan , Maya-García María C. , Pérez-Padilla Rogelio
Published: October 2024

Chronic Obstructive Pulmonary Disease (COPD) exhibits some phenotypic differences between patients with biomass smoke inhalation (COPD-B) and tobacco smoking (COPD-T), as COPD-B is characterized by less emphysema but more airway disease and vascular pulmonary remodeling; these characteristics were related for mast cells in lung tissues for COPD-T. Our objective was to characterize the differences between the number of mast cells in COPD-B and COPD-T patients.
METHODS: A cross-sectional study was conducted on lung tissue resections for suspected cancer obtained between 2014 and 2021 from patients with documented COPD due to wood smoke or tobacco exposure. Histological samples were analyzed for mast cell count, CD34 + expression, and structural changes in the lung tissue and pulmonary circulation.
RESULTS: 20 histological samples were analyzed, with significant differences found in mast cell count [median 8 (p25-75, 5–11) vs 2 (p75-25, 0–6), p = 0.016) and severe peribronchiolar fibrosis (60% vs 10%, p = 0.04) between COPD-B and COPD-T patients. A positive correlation (spearman rho = 0.879, p > 0.001) was observed between mast cell count and a gradual increase in pulmonary artery diameter.
CONCLUSION: Compared with COPD-T, patients with COPD-B exhibit more counts of mast cells in lung tissue and peribronchiolar fibrosis than tobacco smoke-exposed patients, suggesting a pathogenic role of mast cells in COPD-B more than in COPD-T.