bluuebunny/crossref_metadata_2025 huggingface dataset:
The correlation between spiritual coping with the lifestyle of hypertension patients in Ploso Kuning village
Authors: Soleha Umdatus , Nurjanah Siti , Erindia Firnanda
Published: May 2024

Introduction: The lifestyle of patients with hypertension is an important factor in treating hypertension, but in fact, the lifestyle of patients with hypertension is still quite bad. A bad lifestyle triggers complications and increases the prevalence of hypertension. The purpose of the study was to analyze the relationship between spiritual coping and the lifestyle of hypertension sufferers.
Methods: The research method uses observational analytics, the independent variable is spiritual coping, the dependent variable is the lifestyle of people with hypertension, and the sampling technique uses simple random sampling. The sampled population is all hypertension sufferers in Ploso Kuning village who are between 26 to 65 years old, can read and are willing to be respondents. The sampling technique used is simple random sampling with a sample size of 108 respondents. Data analysis using Spearman rank correlation test.
Results: The results showed that spiritual coping had a significant effect on the lifestyle of hypertension sufferers with a p-value of 0.000.
Conclusion: The lifestyle of patients with hypertension can be improved by increasing the spiritual coping of the sufferer.
Managing and diagnosing fibromyalgia in psychiatry
Authors: Arizona Popy , Setiawati Yunias
Published: May 2024

Fibromyalgia (FM) is a chronic pain syndrome that is quite common. This syndrome is often not diagnosed correctly because the symptoms are heterogeneous and often overlap with other diseases. In 2010, the American College of Rheumatology (ACR) established a feasible diagnostic criterion for FM then in 2016 ACR revised FM criteria. The clinical problems of FM vary widely and depend on the individual's management, depending on the severity and severity of the complexity, the degree of damage that occurs and the comorbidities in the psychiatric field that most commonly occur in anxiety disorders and depression.
The relationship of motivation and interest with a healthy lifestyle based on self-regulation of motivation theory
Authors: Khamida  , Yusuf Ah , Fitryasari Rizki , Susi Hartati Husnia , Budury Syiddatul , Setiawan Arif Helmi
Published: May 2024

Introduction: Clean and healthy living behavior or healthy lifestyle is the implementation of awareness and experience of a group that aims to maintain and improve health status. However, students in several Islamic boarding schools need to implement this properly due to a lack of motivation and interest. In addition to the pattern of clean and healthy living behavior in Islamic boarding schools, the reason they get related to past interests is still low. Thus, this study aims to determine the relationship between cause and claim in a healthy lifestyle for students.
Methods: The design of this research was cross-sectional. The research sample was all students of class VII at Pesantren Al Hidayah Sidoarjo, with 147 respondents using a simple random sampling technique. The independent variable was motivation and interest. The dependent variable was a healthy lifestyle. The research instrument uses a questionnaire that has been tested for validity and reliability. Data were analyzed by the Spearman rank test with a significance level of = 0.05.
Results: The results of the study were obtained as follows. Based on the characteristics of the sample, it was found that the majority were aged 12 to 15 years (67.3%), while the remaining 32.7% were aged 15 to 18 years. According to gender, most of the respondents were male (51.7%). The results showed a correlation between motivation and interest in a quality, healthy lifestyle (p-value = 0.001). A strong correlation was found between motivation and a healthy lifestyle (r=0.909  and the interest variable p-value = 0.000, so it can be concluded that both have a significant relationship with a healthy lifestyle.
Conclusion: The higher the motivation and interest, the better the clean and healthy behavior of students. The study’s results can be used as a reference so that the caregivers of the Islamic boarding school provide facilities and infrastructure that support the realization of a clean and healthy life behavior for students.
Correlation between stress and insomnia with learning outcomes: a cross sectional study
Authors: Hatmanti Nety Mawarda , Zurmida Ulfa Mazuzin , Septianingrum Yurike , Purwanti Nunik , Maimunah Siti
Published: May 2024

Introduction: Stress can happen anywhere and to anyone. Stress that cannot be controlled causes difficulty in concentration, difficulty remembering lessons, difficulty understanding lessons, frequent dizziness, feeling sluggish, weak and insomnia. Thus, this study aimed to determine the relationship between stress levels and insomnia with student achievement at Pondok Pesantren Tebuireng Jombang.
Method: The research design was correlational analytic using a retrospective research approach—the population of all students in class X-XII at Pondok Tebu Ireng Jombang in February 2022. From 620 children, 243 students were taken by stratified simple random sampling. The independent variables were the level of stress and insomnia, and the dependent variable was the learning achievement. Data collection in this study used a questionnaire (DASS), an insomnia rating scale questionnaire, and learning achievement with a learning report book. The data were analyzed by the Spearman Rho test in SPSS 25.
Results: Based on a characteristic sample from 243 respondents, it was found that most of them were male (59.26%), by the age were 17 years old (34.16%). Several students experienced stress. Luckily the highest stress level they experienced was moderate (31.3%), and the highest grade of insomnia they experienced was moderate. The correlation analysis of stress level and learning achievement obtained r=-0.425 and p=0.001. It indicated a significant correlation between stress level and learning achievement, with a moderate correlation.  A similar finding was also found in the correlation of insomnia with learning achievement (p=0.001; r=-0.482)
Conclusion:  In this study, almost all respondents have a mild stress level and sufficient achievement. Meanwhile, nearly all respondents who experienced mild insomnia had acceptable learning achievement. Both variables correlated with the level of achievement of students. Thus, maintaining stress levels and sleep time among students at a normal level is needed.
The effectiveness of banana consumption on blood pressure, liver function, and lipid function in construction workers
Authors: Andreas Putro Ragil Santoso  , Devyana Dyah Wulandari  , Firdaus  , Rizki Nurmalya Kardina  , Ahmad Jazuly Nabil  , Dewi Kuncoro Yakti Pamungkas  , Salfa Salsabilah Zain  , Marotur Rohima
Published: May 2024

Introduction: Food consumption has a substantial impact on the physical condition of work for unskilled individuals like construction workers because their activity demands a lot of energy. Consumption of bananas can increase energy, so it is hoped that the results of this study can be used as a consideration to maintain the health of construction workers so that they are kept in good condition. The aim of the study was to determine the effectiveness of bananas on blood pressure, liver function, and lipid function.
Methods: This is an experimental study with samples taken from the total population of 15 employees. The blood pressure, liver function, and lipid function measurements in construction workers were made before and after consuming bananas. The analysis of the data in this study was conducted by a paired t test.
Results: Based on the data analysis, the result showed that there was no significant difference in blood pressure and liver function measurements between the workers before and after consuming bananas (p>​​0.05). Meanwhile, the results showed that there was a significant difference in lipid function measurements between the workers before and after consuming bananas (p<​​0.05).
Conclusion: The effectiveness of banana consumption can be seen in the examination of lipid function. However, there is no effect on the blood pressure or liver function of the workers.
The effectiveness of the ERACS (Enhanced Recovery After Caesarean Surgery) method on postoperative pain and the onset of colostrum excretion
Authors: Rahayu Esty Puji , Nisa Fauziyatun , Andriani Ratna Ariesta Dwi , Anggraini Fritria Dwi
Published: May 2024

Background: Riskesdas in 2018 showed that the Caesarean birth rate in Indonesia was 17.6%. In addition to the many benefits of Caesarean section, postoperative patients face various problems ranging from healing after surgery, lactation process constraints and other discomforts. Various studies have been carried out to prove the superiority of the Enhanced Recovery after Caesarean Surgery (ERACS) method. This investigation seeks to evaluate the impact of ERACS on postoperative discomfort and the beginning of colostrum excretion.
Methods: In this study, a control group was used in a quasi-experimental study to assess the degree of postoperative discomfort and the beginning of colostrum excretion between the control group (non-ERACS) and the treatment group (Sectio Caesarean with ERACS method). For this study's simple random sample, there are 30 respondents in each group. The Chi-Square and multivariate logistic regression tests were used to evaluate the data and discover the variables' relationship.
Results: Based on the data analysis, it was found that ERACS was effective in reducing post-operative pain (p<0.001), and the coefficient of determination is 0.645, which means that the ERACS can influence 64.5% of the variation in the postoperative pain score variable. ERACS method is ineffective for accelerating the onset of colostrum excretion p=0.267 (p>0.05).
Conclusion: The type of mother's birth, the mother's psychological changes, pain, and the administration of medicines to the mother are all factors that can impact the mother's ability to excrete colostrum right away after delivery.
Non-motor seizure diagnosed after mild traumatic brain injury: a case report
Authors: Windriya Drestha Pratita , Wiryawan Reryd Arindany , Islamiyah Wardah Rahmatul , Machin Abdulloh
Published: May 2024

Introduction:  In 10% of head injury cases, nonmotor seizures were detected by electroencephalography (EEG) performed in the acute phase.  Nonmotor seizures are often not diagnosed at the start of treatment because the symptoms are often not recognized by the patient's family or doctor. The incidence of seizures in patients with minor head injuries is very low. From the literature, it was found that the type and severity of the head injury is a significant factors in the incidence of post-traumatic seizure. Thus, in this article, we report a case of nonmotor seizures in a patient after a minor head injury.
Case description: An Indonesian female, 53 years old, complained of sudden silence when speaking after 4 days earlier, she fell and hit her head on the right side. There was no loss of consciousness, headache, vomiting or limb weakness. Complaints of motor seizures and a history of previous seizures were denied. There were no cranium defects, hematomas, or open wounds on examination. The results of laboratory tests and non-contrast head CT scans were expected. On electroencephalography (EEG) examination, epileptiform waves were found in the left temporal region. The patient was given anti-seizure drugs, and complaints improved within 2 days of therapy. It is crucial to carry out an EEG examination in the acute phase of a head injury to exclude the possibility of nonmotor seizures and brain dysfunction, which will be at risk of causing seizures later in life after trauma.         Conclusion: EEG examination in the acute phase of head injury is used to exclude the possibility of nonmotor seizures and brain dysfunction, which will be at risk of causing seizures later in life after trauma.
Student perception of nurse communication learning with patients according to pancasila values
Authors: Shodiq M. , Hasina Siti Nur , Maimunah Siti , Afandi Mujad Didien
Published: May 2024

Introduction: Pancasila is the ideology of the state and is a collection or set of values that are believed to be true by the government and the people of Indonesia.  Perception is a person's ability to organize an observation. One of students perception is regarding nurses communication. The research aims are to describe students perception regarding nurses communication between nurses and patients according values of Pancasila.
Method: A design of descriptive study was used with mixed methods approach that combines or associates qualitative and quantitative. Descriptive research was to describe the data obtained from students' perceptions of learning communication between nurses and patients according to the values of Pancasila.
Results: There were 52 nursing students involved in this study. We showed that almost all of the students' perceptions strongly agreed with the application of Pancasila values in nurse-patient communication
Conclusion: Nurse-patient communication has implemented Pancasila values in serving patients in hospitals with evidence that stands out the value of strongly agree and agree answers.
Chronic dialysis patient with severe secondary hyperparathyroidism undergoing parathyroidectomy in Indonesia: a case series
Authors: Nariswari Adaninggar , Tandarto Kevin , Aditiawardana
Published: May 2024

Link of Video Abstract: https://youtu.be/d196XKGsPekBackground: Parathyroidectomy is a method of treating secondary hyperparathyroidism associated with Chronic Kidney Disease (CKD), which has been largely abandoned in developed countries due to the existence of calcimimetic drugs which are reported to be effective in treating secondary hyperparathyroidism in this population. However, in developing countries like Indonesia, the availability of Calcimimetic drugs is still rare and expensive, so that parathyroidectomy can be an option. The study aimed to present four case reports of chronic HD patients with SHPT accompanied by clinical symptoms. As far as our knowledge goes, this is the first case series reported from Indonesia.
Case Presentation: This research is a multicenter case series study. All patients had undergone dialysis for five years and complained of body aches. All calcium levels were within the normal range, while three patients had hyperphosphatemia and one patient had normal phosphate levels. All patients had iPTH levels >1000 pg/ml in the last six months. Before the surgery, all patients had received long-term phosphate-binding drugs, including calcium-based and non-calcium-based drugs and vitamin D3 agonists. All patients underwent total parathyroidectomy with autotransplantation of parathyroid tissue in the right antebrachial regions, except for the second patient who received the transplant in the left antebrachial region due to an AV fistula in the right arm.
Conclusion: In dialysis patients, especially in developing countries, approximately 10.7% of them experience SHPT with PTH levels >1,000 pg/mL, and one study in Indonesia showed that around 35% of patients undergoing chronic hemodialysis had PTH levels >200 pg/ml, making parathyroidectomy a highly possible option considering that medications such as cinacalcet are more expensive and not widely available.
Effects of misoprostol as a drug to induce abortion in the second trimester: a forensic case report
Authors: Syamsun Arfi , Sutjianto Jaury , Rahma Elita , Masadah Rina , Cangara Husni , Nelwan Berti Julian
Published: May 2024

Link of Video Abstract: https://youtu.be/rMasD6pMero
 
Introduction: Induced abortion with misoprostol in the second trimester can be harmful to both mother and fetus, especially when the abortion is self-administered with telemedicine. Considering the effects that might occur in misoprostol usage to induce abortion, we ought to present our experience through this article regarding the effect of misoprostol as a drug to induce abortion in the second trimester.
Case Description: In the first case, a 30-year-old woman engaged in a self-induced abortion at her residence subsequent to consulting with medical personnel at a local community health centre, where she received oral and vaginal administration of misoprostol. Unfortunately, complications arose as the mother experienced post-abortion bleeding, which necessitated a curative procedure. Tragically, the fetus perished in utero due to asphyxia. In the second case, a 20-year-old woman opted to undergo a self-induced abortion at home following consultation and the acquisition of misoprostol from an online source. In cases where fetuses experience asphyxia within the womb, they are unable to exit the uterus spontaneously. Consequently, the mother experienced post-abortion bleeding as an aftermath of the procedure.
Conclusions: Misoprostol-induced abortion in the second trimester causes maternal bleeding and intrauterine fetal mortality. Medical staff should handle abortions professionally, considering into account both the patient's health and the legal considerations.
Retrospective study on nasopharyngeal cancer (RENOCS): outcome management of in-hospital patients
Authors: Romdhoni Achmad Chusnu , Hayyu Fath Rachmadhan  , Yufi Aulia Azmi  , Faisal Yusuf Ashari  , Astri Dewayani
Published: May 2024

Link of Video Abstract: https://youtu.be/J6ZC8xzJB8MBackground: Nasopharyngeal carcinoma (NPC) is distinct from other head and neck cancers in terms of epidemiology, clinical presentation, biological markers, carcinogenic risk factors, and prognostic factors. However, there is only a small amount of information available on NPC in Indonesia, where the recorded mean prevalence is 6.2/100,000 and there are 13,000 new cases reported annually. Numerous treatments are used, and it's important to pinpoint the risk factor that contributes to a poor prognosis. The aim of this study is to look at the outcomes of nasopharyngeal cancer patients who were hospitalized at a referral hospital based on their characteristics and laboratory results.
Methods: Data from medical records were analyzed to conduct a retrospective study. Up to 785 patients who were hospitalized at a single referral hospital from 2018 to 2022 and received a nasopharyngeal cancer diagnosis were included. Data were statistically and descriptively analyzed.
Results: Chronic kidney disease, education level, and tumor, node, metastasis (TNM) classification was associated with patient outcomes (p < 0.05). The results of the multivariate analysis showed that there were significant differences in the variables of chronic kidney disease and pre-treatment albumin levels. Therefore, people with nasopharyngeal cancer who have chronic kidney disease have a 12,151 chance of mortality.
Conclusion: In Indonesia, there is a critical need for efforts to identify NPC as early as possible. These should include public education to increase awareness of the comorbidity status, especially chronic kidney disease to prevent poor outcomes.
Sequencing analysis of anti mullerian hormone in polycystic ovarian syndrome and primary ovarian insufficiency
Authors: Ermanto Budi , Fadilah  , Bowolaksono Anom , Asmarinah  , Djuwantono Tono , Kekalih Aria , Maidarti Mila , Kusuma Wisnu Ananta , Wiweko Budi
Published: May 2024

Link of Video Abstract: https://youtu.be/HvI9j8B9vqE
 
Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is the main cause of ovulation disorders. Primary ovarian insufficiency (POI) is a clinical syndrome characterized by loss of ovarian activity before the age of 40 years. All of these disorders lead to the risk of infertility. Therefore, this study aims to assess the AMH gene sequence and the effect of SNP on AMH levels and function.
Method: This research was a cross-sectional study. The sample was divided into three groups such as PCOS, POI, and control. This study used ELISA and PCR examination methods. Research data were analyzed using IBM SPSS version 22. The statistical analyses used were the ANOVA, Kruskal-Wallis, chi-square, and Spearman tests. A significant p-value was ≤ 0.05.
Results: There were 31 research subjects, 8 POI subjects, 16 PCOS subjects, and 7 control subjects. Overall 30 mutations were found, with two mutations in the gene promoter and 28 mutations in the structure of the AMH gene. Five mutations in the AMH gene structure were missense mutations. 14 SNPs were found in the POI group and 15 SNPs in the PCOS group. There was a significant difference in AMH AMH gene promoter mutation frequency distribution between the POI and PCOS groups at the mutation point 19:g.2249146T>G (p=0.007). In contrast, the mutation point 19:g.2249158T>A was not significantly different (p=0.536). There was no significant correlation between the number of promoter mutations and AMH gene structure with AMH levels in the POI, PCOS and control groups.
Conclusion: There were mutations in the promoter and AMH gene structure of the POI, PCOS, and control groups which caused differences in base sequences. However, in this study, the differences in mutations were not significantly different.
Human heart tissue mitochondria isolation: experience from patients with tetralogy of Fallot
Authors: Hidayat Jefferson Kasan , Widyaningrum Aulia , Zuliani Nadila Amanda , Suyatna Franciscus Dhyanagiri , Soenarto Ratna Farida , Djer Muljadi Muhammad
Published: May 2024

Background: Mitochondria have crucial roles in human cardiomyocyte metabolism. The isolation of mitochondria from various cells and tissues has been described in previous studies. However, the isolation of human heart muscle is rarely performed because of the ethical problems inherent in obtaining fresh human heart muscle samples. Resected infundibular hypertrophy muscle in tetralogy of Fallot surgery provides a fresh sample source without causing ethical issues. This study aimed to isolate mitochondria from patients with tetralogy of Fallot.
Methods: The optimization of mitochondria isolation protocol in this in vitro study was performed to facilitate our study of ischemia and reperfusion injury. The samples of human heart tissue used in this study were resected infundibulum muscle collected during surgery to correct tetralogy of Fallot. Subjects were recruited from Cipto Mangunkusumo Hospital and Jakarta Heart Center Hospital between July 2021 and November 2022. Tissue was collected before aortic cross-clamp applied, after aortic cross-clamping applied and after aortic cross-clamping off. After collected tissue was trimmed and cleaned, mechanical disruption followed by enzymatic disruption using trypsin was performed. Homogenization was then performed with a sonicator. Mitochondria pellet was further obtained by differential fractionation of homogenate.
Results: Mean infundibular tissue weight obtained from the three periods mentioned was 64.92-109.7 mg. Our protein yield was 7.65-8.38 mg/ml. Mean JC-1 was 9945-12430 FLU/mgP. The median value of SDH activity shown by our mitochondria pellet was 17.45-18.12 nmol/min/L).
Conclusion: The fractionation method allowed us to successfully isolate mitochondria from human heart tissue with intact membrane integrity.
Comparison of the efficacy and safety of dorsal inlay graft urethroplasty (DIGU) method with tubularized incised plate urethroplasty (TIPU) method in primary distal hypospadias repair: a systematic review and meta-analysis
Authors: Fauzan Ahmad , Hidayatullah Furqan , Salsabila Sirin , Setiawan Muhammad Rifki , Fitriani Rizka , Rizkyansyah Hafizh Fanani , Yatindra Ida Bagus Gde Tirta Yoga , Renaldo Johan , Djojodimedjo Tarmono
Published: May 2024

Link of Video Abstract: https://youtu.be/r399GEt3guoIntroduction: Tubularized Incised Plate Urethroplasty (TIPU) is a technique that is widely used in distal hypospadias repair. The advantages possessed by this technique are better cosmetics, the meatus is at the tip of the penis, and the phallus is straight. Some researchers believe that a urethral plate with a size of less than 8 mm is unsuitable for the TIPU technique so augmentation with a graft using the dorsal inlay graft urethroplasty (DIGU) technique is needed. To date, there have been no systematic reviews and meta-analyses that have directly compared the efficacy and complications of DIGU and TIPU. Therefore, this study aimed to compare the effectiveness and complications of these two modalities for repair in primary distal hypospadias patients.
Methods: This study is a systematic review study and meta-analysis. The protocol for conducting and compiling this study was based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search was performed on six databases: PubMed, Scopus, Web of Science, ProQuest, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov. The risk of bias in the study will be analyzed using the Cochrane Risk of Bias Tools for Randomized Trials version 2 (RoB 2).
Results: Six studies that met the inclusion criteria were included in the meta-analysis with a total of 381 samples. The success rates (OR 1.46, 95% CI 0.74-2.87, p = 0.28) and urine output (OR 2.54, 95% CI 0.63-10.20, p = 0.19) were not significantly different, while the mean operating time (MOT) (SMD 1.96, 95% CI 1.10-2.82, p < 0.0001) was significantly shorter in TIPU (P < 0.05). The incidence of meatal stenosis was significantly more in TIPU than DIGU significantly (OR 5.11, 95% CI 1.46-17.92, p = 0.01), while fistula (OR 2.93, 95% CI 0.92-9.35, p = 0.07) and dehiscence (OR 3.05, 95% CI 0.81-11.45, p = 0.10) was not significantly different between the two techniques.
Conclusion: TIPU has the advantage of shorter operating time but a higher incidence of meatal stenosis than DIGU.
Leucocytes, thrombocytes and immature platelets in patients with dengue hemorrhagic fever
Authors: Setiawan Ahmad Fahrudi , Yuyun Yueniwati Prabowowati Wajib  , Kusworini Handono  , Setyawan Purnomo Sakti
Published: May 2024

Diagnosis of Dengue Hemorrhagic Fever (DHF) is based on clinical and supporting examinations, including leukocytes and platelets examinations and antigen and antibody tests for the dengue virus. Examining leucocytes, thrombocytes, and immature platelets is a routine protocol in DHF patients. Leucocytes, thrombocytes, and immature platelets in dengue hemorrhagic fever have their characteristics and roles in relation to the disease severity. Prompt and early diagnosis will reduce the risk of disease severity. This review described the characteristics and role of leucocytes, thrombocytes, and immature platelets in dengue hemorrhagic fever.
Analysis of donor hemoglobin levels at the blood transfusion service of Dr. Sardjito Hospital, Yogyakarta
Authors: Sukorini Usi , Galih Retno Martani  , Teguh Triyono
Published: May 2024

Introduction: Blood service is a health service that utilizes human blood as a basic ingredient for humanitarian and non-commercial purposes. Donors in Indonesia are required to have a minimum Hemoglobin (Hb) level of 12.5 g/dL in accordance with National Regulations. It aims to ensure that the donor can tolerate the loss of blood without the appearance of anemia symptoms. This study aims to analyze the Hb levels of donors at the Blood Transfusion Service of Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Method: This analytic observational study applied a retrospective design. The data of 62,221 donors were taken from the donor database of the Blood Transfusion Service of Dr. Sardjito Hospital. The inclusion criteria were donors aged ≥ 17 years and met other donor selection criteria. Donors with incomplete data were excluded. The chi-Square test was performed using the SPSS version 22. The p < 0.05 was considered significant.
Results: The subjects were dominated by male donors, i.e., 48,348 (77.7%), and the most Hb level were 14.1-15.5 g/dL. This range of Hb levels was identified as the highest proportion in all age groups. The Hb levels of 14.1-15.5 g/dL were determined in 5,874 (39.6%) blood group A, 7,332 (39%) blood group B; 1,830 (39.6%) blood group AB and 9,486 (39.5%) blood group O donors.
Conclusions: There was a significant difference in the proportion of donors based on Hb levels, sexes, ABO groups, Rhesus D groups, donation types, and donor statuses (p < 0.001).
Lactate dehydrogenase (LDH) and C-reactive protein (CRP) as a potential prognostic factor in metastatic bone disease (MBD) of proximal femur based on Harris hip score (HHS) underwent cephalomedullary nailing and bipolar hemiarthroplasty
Authors: Wiratnaya I Gede Eka , Mahadhana Sri , Sutheno Andrew , Kuswara Leonardus William , Ustriyana Nyoman Gede Grenata Nanda
Published: May 2024

Introduction: Pathological fractures in the proximal femur are common, often caused by metastatic bone disease (MBD). Treatment options include resection, reconstruction, or fixation. This study explores the prognostic value of C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels in the Harris Hip Score (HHS) for patients with pathological fractures due to MBD.
Methods: Forty patients with pathological fractures were divided into cephalomedullary nail (CM) and bipolar hemiarthroplasty (BHA) groups. CRP and LDH levels were measured. The correlation between CRP, LDH, and HHS was assessed using Pearson's and Spearman's correlation. Multiple linear regression was used to predict HHS from CRP and LDH.
Results: The mean age of patients was 59 years, with 95% having poor HHS. CRP and LDH levels were significantly correlated with HHS (CRP: r = -0.47, p = 0.002; LDH: r = 0.59, p <0.001). Multiple linear regression showed CRP and LDH as predictors of HHS (R² = 0.36, p < 0.001), with the fitted model: "HHS = 95.76 - 0.317*(CRP) - 0.232*(LDH)". Elevated CRP and LDH levels indicate ongoing inflammation and cellular stress, potentially hindering recovery and impacting HHS. CRP's association with adverse prognoses in various cancers is highlighted. LDH's role in cellular stress and metabolism is emphasized. Combining CRP and LDH evaluations enhances the prognostic assessment of MBD and HHS outcomes.
Conclusion: CRP and LDH levels significantly correlate with HHS in patients with MBD-related pathological fractures. Higher levels of CRP and LDH indicate worse functional outcomes. Evaluating these biomarkers aids in assessing disease severity and treatment effectiveness, assisting in informed clinical decisions. This study sheds light on the prognostic potential of CRP and LDH in the context of metastatic bone disease and its impact on hip function and recovery.
Effects of modified hybrid resistance training on dynamic control ratio of knee joint in untrained healthy subjects
Authors: Priyantono Wirawan Indra , Tinduh Damayanti , Sulistiawati Nuniek Nugraheni , Melaniani Soenarnatalina
Published: May 2024

Background: Increased physical inactivity due to the COVID-19 pandemic has the potential to cause leg muscle strength decline due to the decrease in muscle mechanical loading. The hybrid training method uses the force generated by an electrically stimulated antagonist muscle to provide resistance to a voluntarily contracting agonist muscle. This exercise might be an effective choice for strengthening exercises during a pandemic because it does not require external resistance or stabilization devices. In addition, engaging the eccentric contraction of the antagonist muscle while the agonist is contracting concentrically may reduce agonist-antagonist muscle imbalance and reduce the risk of injury. Because the hybrid training system device was difficult to replicate, modifications were carried out using conventional stimulation tools.
Methods: The research was conducted at the Medical Rehabilitation Installation of Dr. Soetomo General Academic Hospital Surabaya. The research subjects were 24 untrained healthy men aged 18-40 years divided into two groups: the treatment group who received modified hybrid strengthening exercises and the control group who received Russian protocol neuromuscular electrical stimulation (Russian NMES), 3 times per week for 4 weeks. Statistical tests were carried out on 12 treatment group subjects and 12 control group subjects who were able to complete the study.
Results: There was a decrease in non-dominant 60o/sec DCR (p-value 0.002) and non-dominant 120o/sec DCR (p-value 0.019) in the treatment group. There was no significant difference in 60o/sec and 120o/sec DCR on both sides of the leg in the control group. There is a significant difference in ΔDCR between the two groups at non-dominant DCR 120o/sec (p-value 0.036).
Conclusion: There was a greater reduction of knee joint DCR in the modified hybrid resistance training compared to the Russian NMES in untrained healthy subjects.
Giant cell tumor of the thoracal spine treated with decompression and posterior stabilization: a case report
Authors: Biakto Karya Triko , Jainal Arifin  , Budiharto Rheza Setiawan , Kennedy Dave
Published: May 2024

Link of Video Abstract: https://youtu.be/9d-gkVfVFX8
 
Background: Giant cell tumors (GCT) are benign tumors that can also develop in the bone. GCTs commonly affect women aged 30-40 years. The spine is a rare site of GCTs, which accounts for 1.4-9.4% of primary spine tumors. Therefore, we aimed to present a case of spinal GCT in a young male adult, which we considered unique due to the unusual age and localization.
Case presentation: We reported an 18-year-old male admitted to Hasanuddin University General Hospital with complaints of paralysis in both lower limbs, lower back pain, loss of sensation in defecation, difficulty in urinating, and tenderness at the T12 level. There was a wound on the sacral region. The mass and osteolytic lesion in the T12 seen on CT scan and MRI, respectively, followed by a biopsy, confirmed the spinal GCT.
Conclusion: The management of spinal GCT requires precise and multidisciplinary treatment planning with a case-by-case approach in order to achieve total or partial tumor resection, neural decompression, and stabilization of the spine.
Phenotypic and genotypic of gram-positive coccus β-hemolysis bacteria isolates from tonsil and nasal of pig and antimicrobial susceptibility test against penicillin G and tetracycline
Authors: Pinatih Komang Januartha Putra , Astuti Komang Tri , Suardana I Wayan , Sukada I Made , Salasia Siti Isrina Oktavia , Supadmanaba I Gede Putu , Wihandani Desak Made
Published: May 2024

Background: The nasal cavity of a pig serves as an entry point and a habitat for the colonization of commensal microbes and pathogenic bacteria such as bacterial zoonosis. This study aimed to identify the phenotypic and genotypic of Gram-positive β-hemolytic organisms collected from nasal and tonsil swabs of pigs that were collected from the abattoir surrounding outbreak area, complete with testing sensitivity test of the bacterial isolates to Penicillin G and Tetracycline antibiotics.
Material and Methods:  Totaling 18 isolates consisting of 9 isolates from nasal and 9 isolates from tonsil of coccus β-Hemolysis bacteria originating from 60 samples were used. These isolates were then conventionally identified, then molecularly using 16S rRNA gene analysis. The sensitivity test was carried out by the Kirby Bauer method following the standards of the Clinical and Laboratory Standards Institute (CLSI).
Results: The results of the phenotypic identification (biochemical test) revealed that 9 out of 18 isolates were identified as Enterococcus spp. Furthermore, the confirmation of isolates by molecular analysis i.e. the 16S rRNA gene showed consistency with the biochemical test,  and there was confirmed as Enterococcus faecium and Enterococcus faecalis. The sensitivity test showed as many as 9 isolates resistant to Penicillin G and Tetracycline,  5 isolates were resistant, 1 isolate was sensitive and 3 were intermediates. Moreover, the results of the sensitivity test to Penicillin G and Tetracycline, 5 out of 9 isolates showed resistance to more than one antibiotic.
Conclusion: The phenotypic and genotypic of Gram-Positive Coccus β-Hemolysis bacteria isolates from the tonsil and nasal of pigs showed as Enterococcus faecium and Enterococcus faecalis. The use of antibiotics such as Penicillin G and Tetracycline is not recommended for the treatment of this agent resulting in most of the agents being resistant.
Diagnostic accuracy test of quantitative pupillary light reflex as an indicator of increased intracranial pressure in traumatic brain injury patients: a cross-sectional study
Authors: Santosa Dhania A. , Kusuma Edward , Rehatta Nancy Margarita
Published: May 2024

Introduction: The gold standard of intracranial pressure (ICP) measurement is an invasive procedure of inserting ICP monitor and one of the limitations of its surrogate, ultrasonography-based (US) optic nerve sheath diameter (ONSD) measurement is operator-dependent. Quantitative pupillary light reflex (PLR) measurement provides objective data promisingly able to predict ICP elevation. The aim of this study was to evaluate diagnostic accuracy of PLR as an indicator of ICP elevation in traumatic brain injury (TBI) patients compared to US-ONSD measurement.
Methods: This was a cross-sectional study involving moderate and severe TBI patients aged 18-65 years without any eye lesion, nor medication and illness that may influence PLR. Healthy volunteers were recruited as control group. ONSD and quantitative PLR measurements (baseline diameter, maximum constriction, constriction velocity, latency and amplitude) were assessed to both groups. The Student t-test or Mann-Whitney U-test was used to compare the ONSD and PLR between case and control group. Further analyses were done to determine the sensitivity, specificity and cut-off value of PLR compared to ONSD in case group.
Result: ONSD measurements or parameters were significantly different between case and control group (p<0.001), while all PLR parameters  were significantly different (p<0.005) except for right eye constriction latency. The baseline diameter of the right eye had the highest accuracy with cut-off value of >3.9 mm (specificity of 100%, sensitivity of 50%). Other PLR components had variable in accuracy.
Conclusion: The baseline diameter of the right eye was the most accurate PLR component as an indicator of ICP elevation, represented by ONSD.
The effect of monosodium glutamate on the risk of oral cancer: a systematic review
Authors: Intan Suwandi Siti Nabillah , Anggraini Jamas Ari , Widyaputra Sunardhi
Published: May 2024

Link of Video Abstract: https://youtu.be/Nk6RJxEL_FU
 
Introduction: Oral cancer is a malignancy, and most cases are diagnosed as oral squamous cell carcinoma. Oral cancer has a multifactorial etiology, one of which is the pattern of food intake. Monosodium glutamate has been widely used by the public as a flavor enhancer. Until now, the safety of MSG has been debated because several studies state that MSG can have both negative and positive effects, so its effect on the risk of developing oral cancer is still unclear. The aim of this study was to find out the effect of MSG on the risk of oral cancer.
Methods: An article search was performed through the Pubmed, ScienceDirect, EBSCOhost, Nature, Scopus, ResearchGate, and Semantic Scholar databases using predefined keywords, inclusion and exclusion criteria, and adapted to the PICO framework. Article writing refers to the PRISMA guidelines.
Results: A total of five selected articles were obtained. Three in vivo study articles describe the effect of MSG, which can cause genotoxicity, a decrease in the quality and quantity of DNA, and changes in the histological structure of the oral mucosa of experimental animals. One case-control study article explained that MSG had the potential to triple the risk of oral cancer, while one cohort study article described the effect of MSG in suppressing post-chemotherapy side effects in head and neck cancer patients.
Conclusion: MSG has the potential to increase the risk of oral cancer because it tends to be more of a carcinogen. It because MSG can induced and increased oxidative stress, which triggers genotoxicity in oral mucosa cells.
The correlation between oxidative stress markers and increasing intracranial pressure: a study of Malondialdehyde (MDA), Superoxide Dismutase (MnSOD), Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NADPH), and catalase
Authors: Sadewo Wismaji , Wanandi Septelia Inawati , Rustam Zuherman , Gunawan Kevin , Nugroho Setyo Widi
Published: May 2024

Link of Video Abstract: https://youtu.be/nINFPi4uVow
 
Background: Abnormalities in the neurosurgical field concerning cranial structure are almost always followed by increased intracranial pressure (ICP), which causes cerebral hypoxia and disrupts the whole cellular system. This study analyzes the correlation between ICP changes and oxidative stress markers, in subjects with various anatomical pathology abnormalities who underwent surgery.
Methods: This was a cross sectional study of 24 subjects with ICP conducted in the Department of Neurosurgery, Cipto Mangunkusumo Hospital, Jakarta, from November to December 2009. In this study, ANOVA analysis has been done to measure the mean difference oxidative stress (MnSOD, NADPH, MDA, and catalase) in subjects with various changes in ICP who have undergone surgery and Spearman analysis to measure the correlation between each oxidative stress markers. Oxidative stress markers were measured from normal brain tissue taken intra-operatively, cerebrospinal fluid (CSF) taken while doing ventriculostomy, and peripheral blood taken from a central vein catheter (CVC).
Results: The results showed that MDA concentrations in blood were significantly correlated with MDA in brain tissue (P = 0.029) in all of the ICP groups, CSF MnSOD concentration and CSF NADPH concentrations correlated with brain tissue NAPDH (p= 0.000) in congenital group and CSF catalase concentration correlated with brain tissue catalase (p = 0.00) in congenital group.
Conclusion: Increased ICP caused by various pathological conditions causes changes in oxidative stress markers in brain cells, CSF and blood. Oxidative stress markers in blood and CSF are correlated strongly with the brain. It is suggested that it could be used to predict intracranial high pressure in all cases with intracranial abnormalities.
Remodeling in early myocardial infarction: alteration of extracellular matrix; Collagen-1, Collagen-3, α-SMA, and α-Actinin in Porcine heart model
Authors: Putra Muhammad Arza , Alwi Idrus , Soetisna Tri Wisesa , Gunanti  , Sandora Normalina , Busro Pribadi Wiranda , Supomo  , Fitria Nur Amalina , Kusuma Tyas Rahmah
Published: May 2024

Link of Video Abstract: https://youtu.be/lThOW40upEc
 
Background: Myocardial infarction (MI) leads to remodeling due to altered cardiac structure and function. The study of MI histopathology in humans or large animals mimicking the human heart is limited. Using the porcine heart model, our study investigated the composition of myocardial extracellular matrix (ECM) in collagen-1, collagen-3, α-smooth muscle actin (α-SMA), and α-actinin before and after myocardial infarction.
Methods: This study used two groups of domestic pigs: the Infarct group (n=4) and the Sham group (n=4). MI was induced by permanent ligation of the proximal branch of the posterior left ventricular artery. Cardiac enzymes, electrocardiography, and echocardiography data were collected before and after ligation. Cardiac tissue was harvested from the infarcted area after 60 minutes of ligation and stained with hematoxylin-eosin and Movat's Pentachrome. Collagen-1, collagen-3, and α-SMA were identified with immunohistochemical labeling, and the labeled area was measured using ImageJ. Meanwhile, α-actinin was visualized using immunofluorescence.
Results: Expression of collagen-1, collagen-3, and α-SMA in the infarct group were significantly decreased after 60 minutes of infarction compared with those in the sham group (p<0.01). The α-actinin was fragmented and diminished in the infarct group. 
Conclusion: Myocardial remodeling was detected 60 minutes after infarction with mild alteration in myocardial histoarchitecture and significant deterioration of ECM composition of collagen-1, collagen-3, α-SMA, and fragmented α-actinin fibers in the porcine heart model.
Effect of low-intensity resistance training with blood flow restriction on functional status in knee osteoarthritis
Authors: Sari Alvita , Pawana I Putu Alit , Utami Ditaruni Asrina , Melaniani Soenarnatalina
Published: May 2024

Background: Knee osteoarthritis is a joint pathology with high prevalence, resulting from the increase of aging and obesity in the world population. Articular cartilage destruction can cause pain and eventually reduces activities of daily living and affects functional status in subjects with knee osteoarthritis. Exercise interventions in knee-OA aimed at increasing knee extensor muscle strength involve high-intensity resistance training but may result in joint pain due to high-compressive forces. Other alternative method includes low-intensity resistance training performed with blood flow restriction, a potential intervention for a patient who does not tolerate high loads due to lower mechanical stress. This study aims to determine the effects of blood flow restriction with low-intensity resistance training on the quadriceps for six weeks on functional status in knee-OA patients.
Methods: Twenty-eight patients aged 50-70 years old with knee-OA in Physical Medicine and Rehabilitation Outpatient Clinic Soetomo Hospital Surabaya were randomized into control and treatment groups. Both groups underwent a 6-week supervised training program consisting of LI-RT (30% 1-RM) two sessions/week. The treatment group received an additional application of blood flow restriction using a cuff on 1/3 of the upper thigh with 50 mmHg occlusion pressure. Both groups were assessed for functional status by self-reported WOMAC questionnaire before and after the protocol.
Results: Both training methods were able to reduce WOMAC pain and improve physical function subscales significantly, but WOMAC stiffness subscales only reduced significantly in low-intensity resistance training with blood flow restriction. There were no significant differences between groups for any domain from WOMAC, nor any significant differences between delta scores (all P > 0.05).
Conclusion: Low-intensity resistance training with and without blood flow restriction was similarly effective in enhancing functional status in subjects with knee osteoarthritis.
The effect of additional transcutaneous auricular vagus nerve stimulation on back muscle endurance of chronic low back pain
Authors: Kusumastuti Retno Nirmala , Andriana Raden Ayu Meisy , Prawitri Yudith Dian , Tinduh Damayanti , Sugianto Paulus , Melaniani Soenarnatalina
Published: May 2024

Background:  This study aims to investigate the effects of adding transcutaneous auricular vagus nerve stimulation (tVNS) to exercise therapy on back extensor muscle endurance of patients with mechanical chronic low back pain (CLBP).
Methods: A randomized controlled group study was conducted on 22 patients with mechanical CLBP aged 16-55. Participants were randomized into an exercise group (control) and an exercise with a tVNS group (experimental). The outcome was back extensor muscle endurance measured by the Biering Sorensen Test (BST), evaluated before and after 2 weeks of intervention
Results: There was a significant improvement in pre-post evaluation in the intervention group (before: 40.30± 31.20 and after: 66.49±45.87, p<0.05), with a large effect size (Cohen’s d=0.918). No difference in pre-post evaluation in the control group (before: 58.18±50.75; after: 66.82±38.56; p>0.05) with a small effect size (Cohen’s d=0.414). There was no significant difference between the delta BST of the two groups (p=0.418).
Conclusion: Our results suggest that no difference was found between the two groups. However, tVNS addition to exercise therapy showed beneficial effects potency on back muscle endurance of the experimental group in CLBP patients during a relatively short period in two weeks of intervention. Further research is needed to confirm the potential of tVNS therapy in CLBP.